# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Bac_DnaA PF00308.18 ACS98681.1 - 1.1e-105 352.3 0.1 1.7e-105 351.7 0.1 1.3 1 0 0 1 1 1 1 Bacterial dnaA protein Bac_DnaA_C PF08299.11 ACS98681.1 - 1.9e-29 101.5 0.1 7.3e-29 99.6 0.0 2.0 2 0 0 2 2 2 1 Bacterial dnaA protein helix-turn-helix DnaA_N PF11638.8 ACS98681.1 - 1.5e-14 53.5 0.6 3.6e-14 52.3 0.6 1.7 1 0 0 1 1 1 1 DnaA N-terminal domain IstB_IS21 PF01695.17 ACS98681.1 - 1.1e-11 44.7 0.0 2.5e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA PF00004.29 ACS98681.1 - 3.1e-07 30.9 0.0 8.5e-07 29.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AFG1_ATPase PF03969.16 ACS98681.1 - 0.0006 18.8 0.2 0.018 14.0 0.1 2.2 1 1 1 2 2 2 1 AFG1-like ATPase RNA_helicase PF00910.22 ACS98681.1 - 0.0018 18.6 0.0 0.0049 17.2 0.0 1.8 1 0 0 1 1 1 1 RNA helicase ATPase_2 PF01637.18 ACS98681.1 - 0.0044 17.0 0.7 0.014 15.3 0.1 2.1 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ACS98681.1 - 0.014 15.6 1.5 2.8 8.2 0.5 3.3 3 1 0 3 3 3 0 AAA domain DUF2075 PF09848.9 ACS98681.1 - 0.076 12.2 0.0 8.4 5.5 0.0 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) Eaf7 PF07904.13 ACS98681.1 - 0.1 13.0 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 AAA_19 PF13245.6 ACS98681.1 - 0.13 12.6 0.0 0.55 10.6 0.0 2.3 1 1 0 1 1 1 0 AAA domain DNA_pol3_beta PF00712.19 ACS98682.1 - 2e-43 147.3 2.1 1.4e-32 112.3 0.1 3.2 3 0 0 3 3 3 3 DNA polymerase III beta subunit, N-terminal domain DNA_pol3_beta_2 PF02767.16 ACS98682.1 - 2.2e-39 134.2 2.0 5.9e-30 103.9 0.1 2.9 3 1 0 3 3 3 2 DNA polymerase III beta subunit, central domain DNA_pol3_beta_3 PF02768.15 ACS98682.1 - 2.2e-36 124.3 4.4 1.7e-32 111.8 0.0 3.6 4 0 0 4 4 4 3 DNA polymerase III beta subunit, C-terminal domain S4_2 PF13275.6 ACS98683.1 - 2.8e-28 97.5 0.1 3e-28 97.4 0.1 1.0 1 0 0 1 1 1 1 S4 domain DIX PF00778.17 ACS98683.1 - 0.069 13.0 0.0 0.086 12.7 0.0 1.1 1 0 0 1 1 1 0 DIX domain SMC_N PF02463.19 ACS98684.1 - 2.4e-18 66.4 0.0 4.4e-18 65.5 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ACS98684.1 - 3.4e-14 53.4 1.4 8.4e-13 48.8 0.1 2.1 1 1 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 ACS98684.1 - 4e-11 43.8 0.0 6.9e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ACS98684.1 - 5.9e-07 29.6 0.1 0.00016 21.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACS98684.1 - 0.00041 20.0 0.0 0.00082 19.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_27 PF13514.6 ACS98684.1 - 0.0043 16.7 0.1 0.007 16.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain DUF2813 PF11398.8 ACS98684.1 - 0.016 14.4 0.0 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) SbcCD_C PF13558.6 ACS98684.1 - 0.024 14.9 0.0 0.088 13.1 0.0 1.9 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF370 PF04025.12 ACS98685.1 - 4.2e-09 36.4 0.3 4.9e-09 36.2 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF370) DNA_gyraseB PF00204.25 ACS98686.1 - 9.8e-69 230.3 0.6 1.6e-68 229.6 0.6 1.3 1 0 0 1 1 1 1 DNA gyrase B DNA_gyraseB_C PF00986.21 ACS98686.1 - 3.3e-31 107.3 0.1 6.5e-31 106.3 0.1 1.5 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 ACS98686.1 - 1.8e-21 76.7 2.3 2.3e-21 76.4 0.3 2.2 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 ACS98686.1 - 8.1e-18 64.6 0.0 3.7e-17 62.4 0.0 2.2 2 0 0 2 2 2 1 Toprim domain HATPase_c_3 PF13589.6 ACS98686.1 - 3.6e-05 23.6 0.1 0.00014 21.7 0.1 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ATPgrasp_YheCD PF14398.6 ACS98687.1 - 5.5e-72 242.1 0.6 7.1e-72 241.7 0.6 1.0 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACS98687.1 - 6e-12 45.4 0.0 5.7e-07 29.1 0.0 2.5 2 1 0 2 2 2 2 Sugar-transfer associated ATP-grasp TTL PF03133.15 ACS98687.1 - 5.8e-08 32.2 0.0 0.0002 20.6 0.0 2.1 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family RimK PF08443.11 ACS98687.1 - 0.0044 16.6 0.0 0.23 11.0 0.0 2.7 1 1 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 ACS98687.1 - 0.0055 16.1 0.0 0.016 14.6 0.0 1.8 2 0 0 2 2 2 1 Prokaryotic glutathione synthetase, ATP-grasp domain CW_7 PF08230.11 ACS98687.1 - 0.096 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 CW_7 repeat DNA_topoisoIV PF00521.20 ACS98688.1 - 8.5e-166 552.1 1.0 1.1e-165 551.7 1.0 1.1 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 ACS98688.1 - 1.6e-79 261.2 16.1 2e-14 52.8 0.2 6.4 6 0 0 6 6 6 6 DNA gyrase C-terminal domain, beta-propeller NTase_sub_bind PF08780.11 ACS98688.1 - 3.3e-07 30.3 1.1 7.4e-07 29.2 1.1 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase substrate binding protein like HTH_19 PF12844.7 ACS98688.1 - 9.1 6.4 7.4 2.3 8.3 0.5 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain HD PF01966.22 ACS98689.1 - 2.5e-14 53.5 0.1 4.3e-14 52.8 0.1 1.4 1 0 0 1 1 1 1 HD domain HD_5 PF13487.6 ACS98689.1 - 3e-14 53.0 0.0 8.9e-14 51.5 0.0 1.8 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 ACS98689.1 - 0.00041 19.9 0.0 0.00071 19.1 0.0 1.4 1 0 0 1 1 1 1 HDOD domain DUF3391 PF11871.8 ACS98689.1 - 0.14 12.7 0.5 0.31 11.6 0.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) Gin PF10764.9 ACS98691.1 - 1.6e-19 69.5 1.0 1.9e-19 69.3 1.0 1.1 1 0 0 1 1 1 1 Inhibitor of sigma-G Gin DUF4428 PF14471.6 ACS98691.1 - 0.0043 16.9 0.3 0.0057 16.5 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4428) zf-C4_ClpX PF06689.13 ACS98691.1 - 0.2 11.6 5.9 0.36 10.7 5.9 1.5 1 1 0 1 1 1 0 ClpX C4-type zinc finger OKR_DC_1 PF01276.20 ACS98692.1 - 4e-67 226.8 0.0 7.6e-67 225.9 0.0 1.3 1 1 1 2 2 2 1 Orn/Lys/Arg decarboxylase, major domain OKR_DC_1_C PF03711.15 ACS98692.1 - 2.9e-11 43.8 0.0 6.4e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, C-terminal domain Aminotran_1_2 PF00155.21 ACS98692.1 - 1.7e-10 40.7 0.0 2.3e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ACS98692.1 - 3.8e-05 22.8 0.0 5.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ACS98692.1 - 0.00013 21.4 0.0 0.00018 20.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Thymidylate_kin PF02223.17 ACS98693.1 - 1.4e-55 187.9 0.0 1.6e-55 187.7 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 ACS98693.1 - 2.7e-10 40.7 0.0 3.5e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 ACS98693.1 - 3.6e-05 23.7 0.0 0.0002 21.3 0.0 1.9 1 1 0 1 1 1 1 Deoxynucleoside kinase AAA_30 PF13604.6 ACS98693.1 - 0.00014 21.7 0.1 0.00021 21.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ACS98693.1 - 0.00047 20.7 0.0 0.0011 19.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 ACS98693.1 - 0.0022 17.1 0.3 0.032 13.3 0.1 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_17 PF13207.6 ACS98693.1 - 0.0024 18.3 0.1 0.0093 16.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain MobB PF03205.14 ACS98693.1 - 0.0034 17.3 0.1 0.0081 16.1 0.1 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 ACS98693.1 - 0.0046 17.2 0.1 0.011 16.0 0.1 1.7 1 1 1 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.9 ACS98693.1 - 0.0063 15.5 0.5 0.01 14.8 0.5 1.2 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain SRP54 PF00448.22 ACS98693.1 - 0.0064 16.1 0.3 0.012 15.3 0.3 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain ABC_tran PF00005.27 ACS98693.1 - 0.0068 16.9 0.0 0.0087 16.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ACS98693.1 - 0.0077 16.6 0.2 0.013 15.9 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 ACS98693.1 - 0.0093 15.3 0.2 0.02 14.2 0.1 1.6 2 0 0 2 2 1 1 Zeta toxin KAP_NTPase PF07693.14 ACS98693.1 - 0.0093 15.2 0.0 0.0093 15.2 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain NACHT PF05729.12 ACS98693.1 - 0.014 15.3 0.3 0.031 14.2 0.3 1.5 1 0 0 1 1 1 0 NACHT domain KTI12 PF08433.10 ACS98693.1 - 0.019 14.4 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.6 ACS98693.1 - 0.02 15.1 0.1 0.04 14.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ACS98693.1 - 0.02 14.8 0.4 0.051 13.5 0.4 1.6 1 0 0 1 1 1 0 NTPase cobW PF02492.19 ACS98693.1 - 0.027 14.1 0.1 0.046 13.3 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 ACS98693.1 - 0.028 13.4 0.3 0.046 12.7 0.3 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 ACS98693.1 - 0.03 14.4 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase PPK2 PF03976.14 ACS98693.1 - 0.036 13.6 0.0 0.084 12.4 0.0 1.6 2 0 0 2 2 2 0 Polyphosphate kinase 2 (PPK2) ATP_bind_1 PF03029.17 ACS98693.1 - 0.036 13.8 0.2 0.073 12.8 0.2 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 ACS98693.1 - 0.04 13.5 0.1 0.075 12.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 ACS98693.1 - 0.076 13.0 0.4 0.16 11.9 0.4 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2075 PF09848.9 ACS98693.1 - 0.088 12.0 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 ACS98693.1 - 0.1 12.6 0.2 0.21 11.6 0.2 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) PRK PF00485.18 ACS98693.1 - 0.11 12.2 0.0 0.65 9.7 0.0 2.0 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RsgA_GTPase PF03193.16 ACS98693.1 - 0.11 12.3 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 ACS98693.1 - 0.13 11.4 0.5 0.2 10.8 0.5 1.3 1 0 0 1 1 1 0 NB-ARC domain CbiA PF01656.23 ACS98693.1 - 0.14 12.3 0.4 0.42 10.7 0.2 1.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain PIF1 PF05970.14 ACS98693.1 - 0.15 11.2 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 PIF1-like helicase AAA_19 PF13245.6 ACS98693.1 - 0.16 12.3 1.0 0.21 11.9 1.0 1.7 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 ACS98693.1 - 0.18 11.5 0.1 0.31 10.8 0.1 1.5 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CdAMP_rec PF06153.11 ACS98694.1 - 3.2e-52 175.3 0.1 3.6e-52 175.2 0.1 1.0 1 0 0 1 1 1 1 Cyclic-di-AMP receptor P-II PF00543.22 ACS98694.1 - 0.013 16.1 0.6 0.09 13.4 0.6 2.5 1 1 0 1 1 1 0 Nitrogen regulatory protein P-II DUF327 PF03885.13 ACS98695.1 - 3.4e-40 137.3 0.1 3.9e-40 137.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF327) DNA_pol3_delta2 PF13177.6 ACS98696.1 - 6.4e-55 185.4 0.0 1.7e-54 184.0 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA PF00004.29 ACS98696.1 - 0.00012 22.5 0.1 0.0062 17.0 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNApol3-delta_C PF09115.10 ACS98696.1 - 0.00034 21.1 1.5 0.00034 21.1 1.5 2.2 2 1 1 3 3 3 1 DNA polymerase III, delta subunit, C terminal Mg_chelatase PF01078.21 ACS98696.1 - 0.0019 17.6 0.0 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ACS98696.1 - 0.014 14.7 0.0 0.13 11.4 0.0 2.1 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_5 PF07728.14 ACS98696.1 - 0.03 14.3 0.1 1.3 9.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ACS98696.1 - 0.04 14.3 1.2 1.5 9.2 0.1 2.5 1 1 1 2 2 2 0 AAA ATPase domain PSP1 PF04468.12 ACS98697.1 - 1.6e-30 105.2 4.0 2.3e-30 104.7 4.0 1.2 1 0 0 1 1 1 1 PSP1 C-terminal conserved region TRP_N PF14558.6 ACS98697.1 - 0.071 13.5 0.0 0.086 13.2 0.0 1.4 1 1 0 1 1 1 0 ML-like domain YabA PF06156.13 ACS98698.1 - 4.5e-33 113.9 8.1 1.8e-32 112.0 8.1 1.7 1 1 0 1 1 1 1 Initiation control protein YabA TSC22 PF01166.18 ACS98698.1 - 5.1e-05 23.5 2.4 7e-05 23.1 1.3 1.8 2 0 0 2 2 2 1 TSC-22/dip/bun family Herpes_BLRF2 PF05812.12 ACS98698.1 - 6.8e-05 23.0 1.2 0.00011 22.4 1.2 1.5 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein ZapB PF06005.12 ACS98698.1 - 0.00079 19.8 2.5 0.0011 19.3 2.5 1.4 1 0 0 1 1 1 1 Cell division protein ZapB LRRFIP PF09738.9 ACS98698.1 - 0.002 17.7 2.2 0.0023 17.5 2.2 1.2 1 0 0 1 1 1 1 LRRFIP family HAP1_N PF04849.13 ACS98698.1 - 0.0088 15.3 2.7 0.012 14.8 2.7 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region bZIP_1 PF00170.21 ACS98698.1 - 0.014 15.5 2.8 0.014 15.5 2.8 1.8 2 0 0 2 2 2 0 bZIP transcription factor bZIP_2 PF07716.15 ACS98698.1 - 0.029 14.4 5.5 0.029 14.4 5.5 1.6 2 0 0 2 2 2 0 Basic region leucine zipper NRBF2 PF08961.10 ACS98698.1 - 0.029 14.0 2.3 0.029 14.0 2.3 1.4 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator NYD-SP28_assoc PF14775.6 ACS98698.1 - 0.066 13.3 5.9 0.12 12.5 5.9 1.5 1 1 0 1 1 1 0 Sperm tail C-terminal domain Cytadhesin_P30 PF07271.11 ACS98698.1 - 0.14 11.7 1.0 0.17 11.4 1.0 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 MTS PF05175.14 ACS98699.1 - 9.9e-11 41.5 0.0 2.9e-10 39.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ACS98699.1 - 1.6e-06 28.7 0.1 9.4e-06 26.3 0.1 2.2 2 1 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ACS98699.1 - 6.1e-06 26.0 0.0 9e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_10 PF05971.12 ACS98699.1 - 2e-05 24.1 0.0 2.6e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase Met_10 PF02475.16 ACS98699.1 - 0.0017 18.2 0.1 0.0034 17.1 0.1 1.5 1 1 0 1 1 1 1 Met-10+ like-protein Methyltransf_18 PF12847.7 ACS98699.1 - 0.0017 18.3 0.0 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACS98699.1 - 0.0035 18.0 0.1 0.013 16.2 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 ACS98699.1 - 0.017 14.7 0.0 0.022 14.3 0.0 1.1 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.6 ACS98699.1 - 0.024 14.4 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 ACS98699.1 - 0.092 12.6 0.0 0.18 11.6 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain PrpR_N PF06506.11 ACS98699.1 - 0.095 12.3 0.0 0.53 9.8 0.0 1.9 2 0 0 2 2 2 0 Propionate catabolism activator TP_methylase PF00590.20 ACS98700.1 - 5.5e-27 95.1 0.1 7e-27 94.8 0.1 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases MazE_antitoxin PF04014.18 ACS98701.1 - 3.5e-11 42.8 0.0 4.5e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin MraZ PF02381.18 ACS98701.1 - 0.1 12.6 0.0 0.16 11.9 0.0 1.4 1 1 0 1 1 1 0 MraZ protein, putative antitoxin-like HD PF01966.22 ACS98702.1 - 4.3e-14 52.8 0.0 9.1e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 HD domain TatD_DNase PF01026.21 ACS98703.1 - 4.7e-86 288.3 0.0 5.3e-86 288.1 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase DUF348 PF03990.14 ACS98704.1 - 3.3e-22 78.0 7.6 5.1e-14 51.7 2.7 2.9 2 0 0 2 2 2 2 G5-linked-Ubiquitin-like domain 3D PF06725.11 ACS98704.1 - 7.8e-16 58.0 0.3 1.9e-15 56.8 0.3 1.7 1 0 0 1 1 1 1 3D domain G5 PF07501.12 ACS98704.1 - 8.2e-16 58.2 6.7 8.2e-16 58.2 6.7 2.5 3 0 0 3 3 3 1 G5 domain HlyD_3 PF13437.6 ACS98704.1 - 0.025 15.3 2.8 0.077 13.7 0.6 2.5 1 1 1 2 2 2 0 HlyD family secretion protein DUF4093 PF13331.6 ACS98705.1 - 3.3e-28 98.0 0.0 5.3e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4093) Toprim_4 PF13662.6 ACS98705.1 - 3.5e-07 30.6 0.2 6.8e-07 29.7 0.2 1.5 1 0 0 1 1 1 1 Toprim domain Toprim PF01751.22 ACS98705.1 - 7.1e-05 23.0 0.2 0.00031 20.9 0.3 2.0 2 1 0 2 2 2 1 Toprim domain Toprim_2 PF13155.6 ACS98705.1 - 0.00086 19.7 0.0 0.0014 19.0 0.0 1.4 1 0 0 1 1 1 1 Toprim-like RrnaAD PF00398.20 ACS98706.1 - 4e-68 229.4 0.0 4.9e-68 229.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase NodS PF05401.11 ACS98706.1 - 4e-05 23.3 0.0 6.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_11 PF08241.12 ACS98706.1 - 0.00028 21.5 0.0 0.00055 20.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACS98706.1 - 0.0003 21.5 0.0 0.00053 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACS98706.1 - 0.012 16.3 0.0 0.022 15.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 ACS98706.1 - 0.049 13.5 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_U57 PF05582.12 ACS98708.1 - 4.2e-107 357.6 0.0 4.8e-107 357.4 0.0 1.0 1 0 0 1 1 1 1 YabG peptidase U57 ABC_transp_aux PF09822.9 ACS98708.1 - 0.0062 16.0 0.0 0.0081 15.7 0.0 1.3 1 0 0 1 1 1 1 ABC-type uncharacterized transport system VEG PF06257.11 ACS98709.1 - 8.2e-31 105.9 0.1 1e-30 105.6 0.1 1.1 1 0 0 1 1 1 1 Biofilm formation stimulator VEG SASP PF00269.20 ACS98710.1 - 1.5e-07 31.3 0.2 2.2e-07 30.8 0.2 1.2 1 0 0 1 1 1 1 Small, acid-soluble spore proteins, alpha/beta type GHMP_kinases_C PF08544.13 ACS98711.1 - 8.1e-11 42.2 0.0 1.8e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 ACS98711.1 - 1.2e-10 41.5 0.1 2.9e-10 40.3 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain PuR_N PF09182.10 ACS98712.1 - 3.6e-31 106.9 0.0 7.6e-31 105.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial purine repressor, N-terminal Pribosyltran PF00156.27 ACS98712.1 - 6.4e-19 68.0 0.2 8.7e-19 67.6 0.2 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Ribonuc_L-PSP PF01042.21 ACS98713.1 - 3.3e-46 156.2 0.1 3.7e-46 156.1 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP YjgF_endoribonc PF14588.6 ACS98713.1 - 0.006 16.7 0.0 0.0072 16.5 0.0 1.4 1 1 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease SpoVG PF04026.12 ACS98714.1 - 3.8e-37 126.3 0.2 4.5e-37 126.1 0.2 1.1 1 0 0 1 1 1 1 SpoVG Hexapep PF00132.24 ACS98715.1 - 7.4e-27 92.0 17.4 3.6e-07 29.7 0.5 5.6 3 2 3 6 6 6 6 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 ACS98715.1 - 9.4e-21 74.8 0.4 5.6e-20 72.3 0.2 2.0 2 0 0 2 2 2 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 ACS98715.1 - 1.6e-17 63.9 0.1 2.4e-17 63.4 0.1 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.6 ACS98715.1 - 6.8e-12 44.9 16.4 9.4e-06 25.3 0.6 5.9 5 1 1 6 6 6 4 Hexapeptide repeat of succinyl-transferase IspD PF01128.19 ACS98715.1 - 5.5e-09 36.1 2.2 1.7e-08 34.5 1.4 2.0 2 0 0 2 2 2 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 ACS98715.1 - 1.8e-05 24.7 0.0 4.2e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 Cytidylyltransferase CofC PF01983.16 ACS98715.1 - 3.6e-05 23.1 0.0 5.8e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Guanylyl transferase CofC like DUF2064 PF09837.9 ACS98715.1 - 0.061 13.1 0.2 0.17 11.7 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2064) DUF4954 PF16314.5 ACS98715.1 - 0.33 9.0 2.5 0.68 8.0 1.4 1.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4954) Ribosomal_TL5_C PF14693.6 ACS98716.1 - 4.4e-25 87.9 0.6 9.8e-25 86.7 0.6 1.6 1 0 0 1 1 1 1 Ribosomal protein TL5, C-terminal domain Ribosomal_L25p PF01386.19 ACS98716.1 - 3.4e-21 75.5 0.0 7.7e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 Ribosomal L25p family Pept_tRNA_hydro PF01195.19 ACS98717.1 - 5.9e-63 211.9 0.0 6.7e-63 211.7 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase DUF2290 PF10053.9 ACS98717.1 - 0.098 12.1 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2290) DUF4165 PF13752.6 ACS98717.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4165) DUF2757 PF10955.8 ACS98718.1 - 3.5e-29 100.9 0.1 4.1e-29 100.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2757) Zn_ribbon_SprT PF17283.2 ACS98718.1 - 0.018 14.9 0.5 0.36 10.8 0.2 2.1 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zinc_ribbon_10 PF10058.9 ACS98718.1 - 0.019 14.7 0.4 0.71 9.6 0.1 2.2 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 ACS98718.1 - 0.058 13.4 0.1 0.12 12.4 0.1 1.5 1 1 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 ACS98718.1 - 0.1 12.6 0.9 1.8 8.6 0.9 2.1 1 1 0 1 1 1 0 zinc-ribbons zf-BED PF02892.15 ACS98718.1 - 0.16 12.0 1.5 4.9 7.3 0.0 2.3 2 0 0 2 2 2 0 BED zinc finger CarD_CdnL_TRCF PF02559.16 ACS98719.1 - 2.6e-30 105.0 2.4 6.2e-30 103.8 0.8 2.6 2 0 0 2 2 2 1 CarD-like/TRCF domain TRCF PF03461.15 ACS98719.1 - 2.4e-27 95.2 0.7 7.4e-27 93.6 0.7 1.9 1 0 0 1 1 1 1 TRCF domain UvrB_inter PF17757.1 ACS98719.1 - 7.1e-22 77.4 0.0 2.7e-21 75.6 0.0 2.1 1 0 0 1 1 1 1 UvrB interaction domain Helicase_C PF00271.31 ACS98719.1 - 9.2e-22 77.5 0.6 3.3e-17 62.8 0.0 3.3 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.29 ACS98719.1 - 5.5e-18 65.3 1.8 2.2e-17 63.4 0.1 2.8 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 ACS98719.1 - 3.2e-09 37.0 0.0 8.4e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 ACS98719.1 - 2e-06 26.8 0.1 0.00016 20.5 0.0 2.6 3 0 0 3 3 3 1 SNF2 family N-terminal domain AAA_22 PF13401.6 ACS98719.1 - 0.00096 19.4 0.5 0.022 15.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain SecA_DEAD PF07517.14 ACS98719.1 - 0.057 12.7 0.0 0.26 10.5 0.0 2.1 2 0 0 2 2 2 0 SecA DEAD-like domain Rotamase_3 PF13616.6 ACS98720.1 - 3.1e-23 82.5 0.1 3.1e-23 82.5 0.1 2.5 3 0 0 3 3 3 1 PPIC-type PPIASE domain Rotamase PF00639.21 ACS98720.1 - 1.2e-18 67.8 1.6 5.7e-18 65.7 0.0 2.4 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 ACS98720.1 - 5.1e-12 46.7 3.9 5.1e-12 46.7 3.9 2.9 2 1 0 2 2 2 1 PPIC-type PPIASE domain SurA_N_2 PF13623.6 ACS98720.1 - 7.9e-06 25.8 2.6 1.7e-05 24.7 1.1 2.2 1 1 1 2 2 2 1 SurA N-terminal domain SurA_N_3 PF13624.6 ACS98720.1 - 3.5e-05 23.6 0.8 9.4e-05 22.2 0.4 1.9 1 1 1 2 2 2 1 SurA N-terminal domain Band_7 PF01145.25 ACS98721.1 - 3.8e-25 88.9 6.2 5.3e-25 88.4 6.2 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF2606 PF10794.9 ACS98721.1 - 0.13 12.0 3.0 1 9.1 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2606) GlutR_dimer PF00745.20 ACS98721.1 - 0.14 12.6 2.1 12 6.4 0.4 2.3 1 1 1 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain HicB PF05534.12 ACS98722.1 - 0.00036 20.3 0.0 0.00048 19.9 0.0 1.2 1 0 0 1 1 1 1 HicB family Arc PF03869.14 ACS98722.1 - 0.0049 16.7 0.0 0.0056 16.5 0.0 1.1 1 0 0 1 1 1 1 Arc-like DNA binding domain RHH_5 PF07878.11 ACS98722.1 - 0.0062 16.4 0.0 0.0073 16.2 0.0 1.1 1 0 0 1 1 1 1 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 RHH_7 PF16777.5 ACS98722.1 - 0.057 13.8 0.0 0.14 12.6 0.0 1.6 1 1 1 2 2 2 0 Transcriptional regulator, RHH-like, CopG ParD_like PF11903.8 ACS98722.1 - 0.072 13.2 0.0 0.085 12.9 0.0 1.1 1 0 0 1 1 1 0 ParD-like antitoxin of type II bacterial toxin-antitoxin system DUF4100 PF13352.6 ACS98722.1 - 0.23 11.2 0.0 0.24 11.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) SpoVT_C PF15714.5 ACS98723.1 - 1.2e-45 154.6 0.5 1.7e-45 154.2 0.5 1.2 1 0 0 1 1 1 1 Stage V sporulation protein T C-terminal, transcription factor MazE_antitoxin PF04014.18 ACS98723.1 - 1e-10 41.2 3.0 1.4e-10 40.8 2.1 1.7 2 0 0 2 2 2 1 Antidote-toxin recognition MazE, bacterial antitoxin GAF PF01590.26 ACS98723.1 - 0.0095 16.6 0.0 0.017 15.7 0.0 1.4 1 1 0 1 1 1 1 GAF domain PrlF_antitoxin PF15937.5 ACS98723.1 - 0.01 16.2 0.0 0.051 14.0 0.0 1.9 2 0 0 2 2 2 0 prlF antitoxin for toxin YhaV_toxin GAF_3 PF13492.6 ACS98723.1 - 0.048 14.0 0.0 0.07 13.5 0.0 1.3 1 1 0 1 1 1 0 GAF domain Ldh_1_C PF02866.18 ACS98723.1 - 0.071 13.0 0.2 0.095 12.6 0.2 1.3 1 1 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain AraC_binding PF02311.19 ACS98724.1 - 1.9e-20 73.2 1.1 2.7e-20 72.6 1.1 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_AraC PF00165.23 ACS98724.1 - 7.7e-18 64.1 0.0 1.5e-07 31.3 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACS98724.1 - 7.5e-17 61.4 0.1 1.4e-16 60.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding_2 PF14525.6 ACS98724.1 - 0.013 15.2 0.0 0.034 13.8 0.0 1.6 2 0 0 2 2 2 0 AraC-binding-like domain HTH_Crp_2 PF13545.6 ACS98724.1 - 0.026 14.5 0.0 0.4 10.7 0.0 2.5 2 1 0 2 2 2 0 Crp-like helix-turn-helix domain MarR_2 PF12802.7 ACS98724.1 - 0.027 14.3 0.0 13 5.8 0.0 2.7 2 0 0 2 2 2 0 MarR family Cupin_2 PF07883.11 ACS98724.1 - 0.052 13.3 0.1 0.086 12.6 0.1 1.3 1 0 0 1 1 1 0 Cupin domain Crp PF00325.20 ACS98724.1 - 0.061 13.0 0.0 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family Glyco_hydro_4C PF11975.8 ACS98725.1 - 5.8e-71 238.9 0.5 7.7e-71 238.5 0.5 1.2 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase C-terminal domain Glyco_hydro_4 PF02056.16 ACS98725.1 - 3.1e-62 209.4 0.0 4.7e-62 208.8 0.0 1.3 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase Ldh_1_N PF00056.23 ACS98725.1 - 0.0081 16.3 0.1 0.51 10.4 0.0 2.4 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain GyrI-like PF06445.15 ACS98726.1 - 1.9e-22 80.3 0.1 2.4e-22 79.9 0.1 1.1 1 0 0 1 1 1 1 GyrI-like small molecule binding domain Gly_kinase PF02595.15 ACS98727.1 - 1e-148 495.2 7.0 1.2e-148 495.1 7.0 1.0 1 0 0 1 1 1 1 Glycerate kinase family HTH_psq PF05225.16 ACS98727.1 - 1.8 8.4 4.0 0.86 9.4 0.2 2.2 2 0 0 2 2 2 0 helix-turn-helix, Psq domain MazG PF03819.17 ACS98728.1 - 8.7e-32 109.1 2.2 8.3e-22 77.2 0.2 2.4 2 0 0 2 2 2 2 MazG nucleotide pyrophosphohydrolase domain TP_methylase PF00590.20 ACS98728.1 - 2.6e-26 92.9 0.6 5.7e-26 91.8 0.6 1.6 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases PRA-PH PF01503.17 ACS98728.1 - 1.9e-09 37.9 0.9 1.2e-05 25.6 0.2 2.6 2 0 0 2 2 2 2 Phosphoribosyl-ATP pyrophosphohydrolase CENP-U PF13097.6 ACS98728.1 - 0.035 14.1 0.1 0.059 13.3 0.1 1.3 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit Hemerythrin PF01814.23 ACS98728.1 - 0.14 12.8 5.7 3.2 8.4 0.4 3.4 3 0 0 3 3 3 0 Hemerythrin HHE cation binding domain MKRN1_C PF15815.5 ACS98728.1 - 0.2 12.1 1.0 19 5.7 0.1 2.4 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase makorin-1, C-terminal DUF4363 PF14276.6 ACS98728.1 - 0.81 9.8 3.9 1.6 8.9 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) OmpH PF03938.14 ACS98728.1 - 4.7 7.6 6.9 1.7 9.0 3.1 2.1 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Bac_DNA_binding PF00216.21 ACS98729.1 - 8e-34 115.7 0.1 8.8e-34 115.6 0.1 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 ACS98729.1 - 1.3e-09 38.2 0.0 1.4e-09 38.1 0.0 1.0 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_euk_2 PF18289.1 ACS98729.1 - 0.0023 18.1 0.0 0.0031 17.6 0.0 1.2 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 HU-CCDC81_bac_2 PF18175.1 ACS98729.1 - 0.034 14.0 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 S4 PF01479.25 ACS98730.1 - 1.2e-10 40.9 0.2 1.8e-10 40.4 0.2 1.3 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 ACS98730.1 - 0.0017 18.2 0.5 0.0026 17.5 0.3 1.5 1 1 0 1 1 1 1 S4 domain DUF2057 PF09829.9 ACS98730.1 - 0.039 14.1 0.0 0.048 13.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) Ub-Mut7C PF14451.6 ACS98730.1 - 0.12 12.3 0.0 0.32 10.9 0.0 1.8 2 1 0 2 2 2 0 Mut7-C ubiquitin NfeD PF01957.18 ACS98730.1 - 0.13 12.7 1.9 0.18 12.2 1.9 1.3 1 1 0 1 1 1 0 NfeD-like C-terminal, partner-binding UPF0259 PF06790.11 ACS98731.1 - 4e-05 23.5 5.8 4e-05 23.5 5.8 2.1 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0259) DUF817 PF05675.12 ACS98732.1 - 1.5e-103 345.6 22.7 1.8e-103 345.4 22.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF817) YabP PF07873.11 ACS98733.1 - 3.7e-19 68.3 0.3 4.3e-19 68.0 0.3 1.1 1 0 0 1 1 1 1 YabP family Spore_YabQ PF09578.10 ACS98734.1 - 5.9e-22 77.7 7.2 5.9e-22 77.7 7.2 2.3 2 1 0 2 2 2 1 Spore cortex protein YabQ (Spore_YabQ) DivIC PF04977.15 ACS98735.1 - 1.9e-14 53.2 0.8 2.1e-14 53.0 0.8 1.1 1 0 0 1 1 1 1 Septum formation initiator FtsL PF04999.13 ACS98735.1 - 0.00024 21.1 0.1 0.00028 20.8 0.1 1.0 1 0 0 1 1 1 1 Cell division protein FtsL Filament PF00038.21 ACS98735.1 - 0.0039 16.8 0.2 0.0042 16.7 0.2 1.1 1 0 0 1 1 1 1 Intermediate filament protein CAV_VP3 PF04771.12 ACS98735.1 - 0.029 14.5 0.0 0.034 14.3 0.0 1.1 1 0 0 1 1 1 0 Chicken anaemia virus VP-3 protein S1 PF00575.23 ACS98736.1 - 4.8e-21 74.9 5.5 6.4e-21 74.5 5.5 1.2 1 0 0 1 1 1 1 S1 RNA binding domain S1_2 PF13509.6 ACS98736.1 - 0.024 14.7 0.2 0.34 11.0 0.2 2.3 1 1 0 1 1 1 0 S1 domain SpoIIE PF07228.12 ACS98738.1 - 1.6e-36 126.0 0.1 3.7e-36 124.9 0.1 1.6 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ACS98738.1 - 0.00032 20.4 0.0 0.6 9.7 0.0 2.7 2 0 0 2 2 2 2 Protein phosphatase 2C DUF1924 PF09086.11 ACS98738.1 - 0.022 15.1 0.6 0.05 14.0 0.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1924) TSNAXIP1_N PF15739.5 ACS98738.1 - 0.1 13.0 1.2 3.7 8.0 0.3 2.4 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus VWA PF00092.28 ACS98739.1 - 7.2e-10 39.4 0.0 0.0015 18.8 0.0 2.3 2 1 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 ACS98739.1 - 0.00029 21.4 0.1 0.0013 19.4 0.0 2.0 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA_3 PF13768.6 ACS98739.1 - 0.00087 19.3 0.5 0.83 9.6 0.0 2.5 3 0 0 3 3 3 2 von Willebrand factor type A domain DUF1194 PF06707.11 ACS98739.1 - 0.028 13.7 0.6 0.16 11.1 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1194) YjeF_N PF03853.15 ACS98739.1 - 0.042 13.7 1.2 0.18 11.7 1.2 1.8 1 1 0 1 1 1 0 YjeF-related protein N-terminus Pkinase PF00069.25 ACS98740.1 - 3.6e-09 36.4 0.0 5.2e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ACS98740.1 - 0.00019 21.5 0.4 0.39 10.6 0.0 2.5 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 ACS98740.1 - 0.00038 19.8 0.0 0.00062 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase ATP_bind_3 PF01171.20 ACS98741.1 - 1.5e-57 194.3 0.1 2.2e-57 193.8 0.1 1.2 1 0 0 1 1 1 1 PP-loop family TilS_C PF11734.8 ACS98741.1 - 5.5e-14 51.4 0.0 1.9e-13 49.6 0.0 1.9 1 0 0 1 1 1 1 TilS substrate C-terminal domain QueC PF06508.13 ACS98741.1 - 8.8e-07 28.6 0.0 0.0013 18.3 0.0 2.2 1 1 1 2 2 2 2 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 ACS98741.1 - 1.3e-05 25.3 0.0 0.00015 21.9 0.0 2.5 2 1 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family tRNA_Me_trans PF03054.16 ACS98741.1 - 0.0093 14.8 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase B3_4 PF03483.17 ACS98741.1 - 0.013 15.2 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 B3/4 domain Usp PF00582.26 ACS98741.1 - 0.016 15.7 1.1 0.042 14.3 1.1 1.7 1 1 0 1 1 1 0 Universal stress protein family DUF218 PF02698.17 ACS98741.1 - 0.081 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 DUF218 domain Pribosyltran PF00156.27 ACS98742.1 - 5e-29 100.9 0.2 5.9e-29 100.6 0.2 1.0 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Transglut_core2 PF13369.6 ACS98742.1 - 0.009 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily UPRTase PF14681.6 ACS98742.1 - 0.058 12.8 0.0 0.075 12.5 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Peptidase_M41 PF01434.18 ACS98743.1 - 1.7e-73 246.5 0.5 3e-73 245.7 0.5 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ACS98743.1 - 4.7e-46 156.5 0.0 1.2e-45 155.1 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ACS98743.1 - 1.2e-13 50.6 0.6 2.7e-13 49.5 0.6 1.6 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 ACS98743.1 - 1.1e-07 32.1 1.4 0.00036 20.9 0.6 2.5 2 0 0 2 2 2 2 FtsH Extracellular AAA_5 PF07728.14 ACS98743.1 - 2.1e-05 24.6 0.0 0.00013 22.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 ACS98743.1 - 6.7e-05 22.3 0.0 0.00018 20.8 0.0 1.7 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 ACS98743.1 - 0.00015 22.2 1.2 0.0051 17.2 0.1 3.0 2 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 ACS98743.1 - 0.00033 20.4 0.0 0.00095 18.9 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ACS98743.1 - 0.0026 18.0 0.1 0.061 13.6 0.1 2.5 1 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ACS98743.1 - 0.0028 17.8 0.0 0.0084 16.3 0.0 1.8 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 ACS98743.1 - 0.0065 16.2 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 ACS98743.1 - 0.015 14.7 0.1 0.031 13.6 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ACS98743.1 - 0.033 14.7 0.1 0.14 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 ACS98743.1 - 0.038 14.1 0.0 0.13 12.4 0.0 1.9 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 ACS98743.1 - 0.062 12.9 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 ACS98743.1 - 0.063 13.7 0.0 0.19 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ACS98743.1 - 0.071 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ACS98743.1 - 0.078 12.5 0.2 0.37 10.3 0.2 2.1 1 1 0 1 1 1 0 P-loop containing dynein motor region SpoVT_C PF15714.5 ACS98743.1 - 0.079 13.0 0.1 0.19 11.8 0.1 1.6 1 0 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor TraG_N PF07916.11 ACS98743.1 - 1.5 7.6 2.9 0.97 8.2 0.0 1.8 2 0 0 2 2 2 0 TraG-like protein, N-terminal region Bmp PF02608.14 ACS98744.1 - 5.5e-82 275.1 6.8 6.8e-82 274.8 6.8 1.0 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like LPAM_2 PF13627.6 ACS98744.1 - 0.053 13.4 1.0 0.099 12.5 1.0 1.5 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site ABC_tran PF00005.27 ACS98745.1 - 6e-52 175.8 0.0 2e-30 106.1 0.0 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACS98745.1 - 9.3e-08 32.2 0.3 0.014 15.2 0.1 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACS98745.1 - 0.00012 21.7 0.2 0.0034 17.1 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACS98745.1 - 0.00017 21.5 0.2 0.002 18.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 ACS98745.1 - 0.0013 18.2 4.0 0.0061 16.0 0.5 2.9 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ACS98745.1 - 0.0021 18.6 0.6 0.0045 17.5 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 ACS98745.1 - 0.015 15.0 3.1 0.86 9.2 0.2 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_27 PF13514.6 ACS98745.1 - 0.016 14.8 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACS98745.1 - 0.031 14.4 0.6 0.27 11.3 0.0 2.6 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_22 PF13401.6 ACS98745.1 - 0.033 14.5 0.5 0.2 11.9 0.5 2.1 1 1 0 1 1 1 0 AAA domain Bac_DnaA PF00308.18 ACS98745.1 - 0.076 12.8 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_30 PF13604.6 ACS98745.1 - 0.092 12.4 0.3 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain CobA_CobO_BtuR PF02572.15 ACS98745.1 - 0.1 12.8 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP BPD_transp_2 PF02653.16 ACS98746.1 - 4.6e-44 150.6 34.5 4.6e-44 150.6 34.5 1.9 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component WCOR413 PF05562.11 ACS98746.1 - 0.054 13.4 3.0 0.12 12.2 0.1 2.6 2 1 0 2 2 2 0 Cold acclimation protein WCOR413 BPD_transp_2 PF02653.16 ACS98747.1 - 9e-42 143.1 32.4 1.1e-41 142.8 32.4 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component Bac_export_3 PF01313.19 ACS98747.1 - 2.6 8.1 9.4 1.1 9.3 5.1 2.6 2 1 0 2 2 2 0 Bacterial export proteins, family 3 NadA PF02445.16 ACS98748.1 - 1.1e-122 409.0 2.6 1.2e-122 408.8 2.6 1.0 1 0 0 1 1 1 1 Quinolinate synthetase A protein NAD_binding_1 PF00175.21 ACS98748.1 - 0.00053 20.6 0.2 0.26 11.9 0.0 3.2 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain FAD_binding_2 PF00890.24 ACS98749.1 - 3.6e-97 326.1 0.4 4.4e-97 325.8 0.4 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 ACS98749.1 - 3e-20 72.5 0.4 5e-19 68.6 0.4 2.2 1 1 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 ACS98749.1 - 1.2e-08 34.6 0.1 5.3e-05 22.6 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACS98749.1 - 5.8e-07 29.4 0.6 1.2e-06 28.4 0.6 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ACS98749.1 - 3.8e-06 26.5 0.0 0.0025 17.2 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 ACS98749.1 - 1.4e-05 24.0 0.3 2.6e-05 23.1 0.0 1.5 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 ACS98749.1 - 0.00078 18.6 0.0 0.002 17.3 0.0 1.6 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 ACS98749.1 - 0.0064 15.8 0.6 0.064 12.5 0.1 2.8 3 1 1 4 4 4 1 Thi4 family NAD_binding_8 PF13450.6 ACS98749.1 - 0.016 15.4 0.0 0.036 14.3 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ACS98749.1 - 0.016 14.3 0.1 0.037 13.1 0.0 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 ACS98749.1 - 0.076 12.2 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase QRPTase_C PF01729.19 ACS98750.1 - 8e-64 214.5 0.8 1e-63 214.1 0.8 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 ACS98750.1 - 6.6e-30 103.0 0.3 1.5e-29 101.8 0.1 1.8 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain IMPDH PF00478.25 ACS98750.1 - 0.00032 19.8 0.9 0.00038 19.6 0.9 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Biotin_lipoyl PF00364.22 ACS98750.1 - 0.0055 16.5 1.6 0.12 12.3 0.2 2.5 2 0 0 2 2 2 1 Biotin-requiring enzyme DUF2254 PF10011.9 ACS98750.1 - 0.034 13.0 0.0 0.047 12.5 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Peptidase_M23 PF01551.22 ACS98750.1 - 0.055 13.7 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Peptidase family M23 Biotin_lipoyl_2 PF13533.6 ACS98750.1 - 0.097 12.5 0.0 0.27 11.1 0.0 1.8 1 0 0 1 1 1 0 Biotin-lipoyl like ATP-synt_ab_Xtn PF16886.5 ACS98750.1 - 0.17 11.8 0.1 0.46 10.4 0.0 1.8 2 0 0 2 2 2 0 ATPsynthase alpha/beta subunit N-term extension Pan_kinase PF03309.14 ACS98751.1 - 1.5e-72 243.8 0.0 1.8e-72 243.5 0.0 1.1 1 0 0 1 1 1 1 Type III pantothenate kinase HSP33 PF01430.19 ACS98752.1 - 1.2e-86 290.5 0.0 1.3e-86 290.3 0.0 1.0 1 0 0 1 1 1 1 Hsp33 protein Elf1 PF05129.13 ACS98752.1 - 0.027 14.5 0.4 0.056 13.5 0.4 1.5 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like Deltaretro_Tax PF05599.11 ACS98752.1 - 0.17 12.4 0.0 0.26 11.8 0.0 1.3 1 0 0 1 1 1 0 Deltaretrovirus Tax protein Rotamase PF00639.21 ACS98753.1 - 3.5e-14 53.5 0.1 1.4e-13 51.6 0.0 2.0 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 ACS98753.1 - 1.7e-11 45.0 0.8 9.7e-11 42.6 0.0 2.3 2 1 1 3 3 3 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 ACS98753.1 - 8.1e-11 42.5 0.0 2.2e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 PPIC-type PPIASE domain SurA_N_3 PF13624.6 ACS98753.1 - 2.8e-06 27.2 2.2 6.3e-05 22.8 2.2 2.6 1 1 0 1 1 1 1 SurA N-terminal domain Pex19 PF04614.12 ACS98753.1 - 0.0025 17.6 0.3 0.0046 16.8 0.3 1.3 1 0 0 1 1 1 1 Pex19 protein family RE_AlwI PF09491.10 ACS98753.1 - 0.019 13.8 0.1 0.023 13.5 0.1 1.1 1 0 0 1 1 1 0 AlwI restriction endonuclease DUF3738 PF12543.8 ACS98753.1 - 0.079 13.1 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3738) PALP PF00291.25 ACS98754.1 - 3.7e-73 246.5 0.8 4.1e-73 246.4 0.8 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 ACS98754.1 - 0.00011 22.1 0.6 0.0013 18.7 0.1 2.3 2 1 0 2 2 2 1 Zinc-binding dehydrogenase Hydrolase_3 PF08282.12 ACS98754.1 - 0.03 14.1 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PK_C PF02887.16 ACS98754.1 - 0.066 13.5 0.2 7.6 6.8 0.0 3.1 2 2 1 3 3 3 0 Pyruvate kinase, alpha/beta domain DUF2188 PF09954.9 ACS98754.1 - 0.092 12.9 1.4 5.8 7.1 0.3 2.9 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2188) LAL_C2 PF18603.1 ACS98754.1 - 0.29 11.3 1.4 0.49 10.6 0.0 2.1 2 0 0 2 2 2 0 L-amino acid ligase C-terminal domain 2 Chorismate_bind PF00425.18 ACS98755.1 - 4e-98 328.1 0.0 5.7e-98 327.6 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 ACS98755.1 - 3.3e-21 76.0 0.0 6.5e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region DUF4325 PF14213.6 ACS98755.1 - 0.064 13.0 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 STAS-like domain of unknown function (DUF4325) GATase PF00117.28 ACS98756.1 - 1.8e-56 191.0 0.1 2.1e-56 190.7 0.1 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ACS98756.1 - 1e-08 35.2 0.1 3.6e-08 33.4 0.1 1.7 1 1 0 1 1 1 1 Peptidase C26 Aminotran_4 PF01063.19 ACS98757.1 - 2.4e-51 174.7 0.0 2.8e-51 174.5 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV Pterin_bind PF00809.22 ACS98758.1 - 6.3e-83 278.2 0.0 7.3e-83 278.0 0.0 1.0 1 0 0 1 1 1 1 Pterin binding enzyme DUF3046 PF11248.8 ACS98758.1 - 0.0045 17.3 0.2 1.9 8.9 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF3046) Lipase_GDSL_2 PF13472.6 ACS98758.1 - 0.057 13.8 0.4 0.63 10.4 0.1 2.1 1 1 1 2 2 2 0 GDSL-like Lipase/Acylhydrolase family QRPTase_C PF01729.19 ACS98758.1 - 0.064 13.0 0.0 0.16 11.7 0.0 1.6 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain FolB PF02152.18 ACS98759.1 - 2.9e-35 121.2 0.0 3.2e-35 121.0 0.0 1.0 1 0 0 1 1 1 1 Dihydroneopterin aldolase AMPK1_CBM PF16561.5 ACS98759.1 - 0.037 14.3 0.0 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase HPPK PF01288.20 ACS98760.1 - 5.9e-39 133.0 0.0 7.5e-39 132.7 0.0 1.1 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) HTH_3 PF01381.22 ACS98761.1 - 8.4e-16 57.8 0.1 1.1e-15 57.5 0.1 1.1 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ACS98761.1 - 2.4e-11 43.8 0.1 2.7e-11 43.6 0.1 1.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 ACS98761.1 - 2.4e-11 43.5 0.1 2.7e-11 43.3 0.1 1.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 ACS98761.1 - 3.8e-05 24.0 0.0 4.2e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_25 PF13413.6 ACS98761.1 - 0.00015 21.6 0.0 0.00048 19.9 0.0 1.8 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 ACS98761.1 - 0.00042 20.2 0.1 0.00064 19.6 0.1 1.3 1 1 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4 PF04545.16 ACS98761.1 - 0.00058 19.3 0.1 0.0085 15.6 0.0 2.3 2 1 0 2 2 2 1 Sigma-70, region 4 HTH_23 PF13384.6 ACS98761.1 - 0.0049 16.6 0.0 0.016 15.0 0.1 1.7 2 0 0 2 2 2 1 Homeodomain-like domain Trp_repressor PF01371.19 ACS98761.1 - 0.01 15.9 0.0 0.012 15.7 0.0 1.3 1 1 0 1 1 1 0 Trp repressor protein Sigma70_r4_2 PF08281.12 ACS98761.1 - 0.011 15.4 0.0 0.031 14.0 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 Phage_CI_repr PF07022.13 ACS98761.1 - 0.015 15.4 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain MqsA_antitoxin PF15731.5 ACS98761.1 - 0.016 15.3 0.0 0.017 15.2 0.0 1.1 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA Sigma70_ECF PF07638.11 ACS98761.1 - 0.02 14.8 0.0 0.032 14.1 0.0 1.4 1 1 0 1 1 1 0 ECF sigma factor HTH_24 PF13412.6 ACS98761.1 - 0.059 12.9 0.1 0.48 10.0 0.0 2.3 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.6 ACS98761.1 - 0.067 13.2 0.1 0.91 9.5 0.0 2.2 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_10 PF04967.12 ACS98761.1 - 0.076 12.8 0.0 8.3 6.3 0.0 2.2 2 0 0 2 2 2 0 HTH DNA binding domain YdaS_antitoxin PF15943.5 ACS98761.1 - 0.16 11.8 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Dus PF01207.17 ACS98762.1 - 5.3e-107 357.5 0.0 6.5e-107 357.2 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 ACS98762.1 - 0.00011 21.6 0.1 0.38 9.9 0.0 2.2 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase SOR_SNZ PF01680.17 ACS98762.1 - 0.00083 19.2 0.9 0.38 10.5 0.1 2.4 1 1 1 2 2 2 2 SOR/SNZ family NMO PF03060.15 ACS98762.1 - 0.0013 18.2 0.7 0.0025 17.3 0.7 1.6 1 1 0 1 1 1 1 Nitronate monooxygenase MR_MLE_C PF13378.6 ACS98762.1 - 0.0027 17.3 0.1 0.0046 16.5 0.1 1.4 1 1 0 1 1 1 1 Enolase C-terminal domain-like His_biosynth PF00977.21 ACS98762.1 - 0.0034 16.9 0.1 0.015 14.8 0.1 1.6 1 1 0 1 1 1 1 Histidine biosynthesis protein FMN_dh PF01070.18 ACS98762.1 - 0.0034 16.4 0.1 0.0055 15.8 0.1 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase PEP_mutase PF13714.6 ACS98762.1 - 0.0036 16.8 0.1 0.021 14.3 0.1 1.9 1 1 1 2 2 2 2 Phosphoenolpyruvate phosphomutase Oxidored_FMN PF00724.20 ACS98762.1 - 0.017 14.4 0.0 0.6 9.3 0.0 2.3 2 0 0 2 2 2 0 NADH:flavin oxidoreductase / NADH oxidase family NanE PF04131.14 ACS98762.1 - 0.023 13.9 0.1 0.078 12.2 0.0 1.8 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase Trp_ring PF18669.1 ACS98762.1 - 0.03 14.5 0.3 0.06 13.5 0.3 1.5 1 0 0 1 1 1 0 Trimeric autotransporter adhesin Trp ring domain GreA_GreB_N PF03449.15 ACS98763.1 - 3.8e-28 97.4 4.6 5.6e-28 96.9 4.6 1.3 1 0 0 1 1 1 1 Transcription elongation factor, N-terminal GreA_GreB PF01272.19 ACS98763.1 - 4.7e-26 90.5 2.0 7.6e-26 89.8 2.0 1.3 1 0 0 1 1 1 1 Transcription elongation factor, GreA/GreB, C-term tRNA-synt_2 PF00152.20 ACS98764.1 - 9.5e-84 281.1 0.1 1.2e-83 280.8 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ACS98764.1 - 2.9e-18 65.6 0.7 5.7e-18 64.7 0.7 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ACS98764.1 - 1.5e-05 24.6 0.1 0.058 12.9 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Methyltransf_11 PF08241.12 ACS98764.1 - 0.019 15.6 0.0 1.9 9.2 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain CDC24_OB3 PF17244.2 ACS98764.1 - 0.079 12.7 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 Methyltransf_23 PF13489.6 ACS98764.1 - 0.16 11.8 0.0 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain PMT_4TMC PF16192.5 ACS98765.1 - 2.8e-27 95.6 21.5 2.8e-27 95.6 21.5 4.7 5 2 0 5 5 5 1 C-terminal four TMM region of protein-O-mannosyltransferase PMT_2 PF13231.6 ACS98765.1 - 3.4e-16 59.9 59.5 7.2e-13 49.0 12.6 4.9 4 0 0 4 4 4 4 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT PF02366.18 ACS98765.1 - 1.4e-11 44.5 14.2 1.4e-11 44.5 14.2 5.4 3 2 1 4 4 4 2 Dolichyl-phosphate-mannose-protein mannosyltransferase Multi_Drug_Res PF00893.19 ACS98765.1 - 0.018 15.7 0.3 0.018 15.7 0.3 3.7 4 0 0 4 4 4 0 Small Multidrug Resistance protein F5_F8_type_C PF00754.25 ACS98765.1 - 0.062 13.4 1.5 0.12 12.5 1.5 1.4 1 0 0 1 1 1 0 F5/8 type C domain Sigma_reg_N PF13800.6 ACS98765.1 - 0.62 10.4 0.0 0.62 10.4 0.0 4.1 5 0 0 5 5 5 0 Sigma factor regulator N-terminal Glycos_transf_2 PF00535.26 ACS98766.1 - 2.6e-38 131.5 0.1 3.8e-38 131.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACS98766.1 - 1.7e-09 37.9 0.0 2.4e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ACS98766.1 - 1.2e-08 34.7 0.0 2.1e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ACS98766.1 - 0.00032 20.2 0.0 0.00051 19.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 ACS98766.1 - 0.089 13.3 0.0 0.23 12.0 0.0 1.7 1 1 1 2 2 2 0 Glycosyl transferase family 2 GtrA PF04138.14 ACS98767.1 - 9.5e-25 87.1 6.2 1.2e-24 86.8 6.2 1.1 1 0 0 1 1 1 1 GtrA-like protein Acetyltransf_9 PF13527.7 ACS98768.1 - 5.9e-33 113.7 0.0 9.8e-33 113.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_17 PF17668.1 ACS98768.1 - 9.4e-29 100.6 0.1 1.7e-28 99.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain SCP2_2 PF13530.6 ACS98768.1 - 2.7e-21 75.9 0.0 4.4e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 Sterol carrier protein domain Acetyltransf_1 PF00583.25 ACS98768.1 - 4.2e-07 30.2 0.1 1.5e-06 28.4 0.1 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACS98768.1 - 3.3e-05 24.2 0.3 7.8e-05 23.0 0.1 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACS98768.1 - 0.00032 20.6 0.0 0.00066 19.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACS98768.1 - 0.028 14.4 0.0 0.074 13.0 0.0 1.7 1 0 0 1 1 1 0 FR47-like protein Gly_acyl_tr_C PF08444.10 ACS98768.1 - 0.082 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region IMPDH PF00478.25 ACS98769.1 - 5.4e-165 548.5 2.7 6.2e-165 548.3 2.7 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 ACS98769.1 - 4.8e-20 71.8 0.4 1.1e-08 35.4 0.1 3.0 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 ACS98769.1 - 2.1e-10 40.5 11.5 8e-06 25.5 4.1 3.1 2 1 1 3 3 3 2 Nitronate monooxygenase FMN_dh PF01070.18 ACS98769.1 - 7.2e-06 25.3 12.8 8.2e-05 21.8 10.4 3.4 4 1 0 4 4 4 1 FMN-dependent dehydrogenase DHO_dh PF01180.21 ACS98769.1 - 9.8e-06 25.0 6.2 0.0051 16.1 2.2 2.5 1 1 1 2 2 2 2 Dihydroorotate dehydrogenase His_biosynth PF00977.21 ACS98769.1 - 6.4e-05 22.5 3.5 24 4.3 0.3 2.2 1 1 0 1 1 1 0 Histidine biosynthesis protein Aldolase PF01081.19 ACS98769.1 - 0.00084 18.8 1.5 0.0017 17.8 0.6 1.9 1 1 0 1 1 1 1 KDPG and KHG aldolase ThiG PF05690.14 ACS98769.1 - 0.0024 17.2 1.1 0.0024 17.2 1.1 2.0 2 1 0 2 2 2 1 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 ACS98769.1 - 0.0029 16.8 1.6 0.0059 15.8 1.6 1.5 1 0 0 1 1 1 1 Conserved region in glutamate synthase Dus PF01207.17 ACS98769.1 - 0.0099 15.0 0.7 0.021 13.9 0.0 1.7 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) G3P_antiterm PF04309.12 ACS98769.1 - 0.014 14.9 0.9 0.091 12.2 0.1 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator adh_short PF00106.25 ACS98769.1 - 0.015 14.7 0.4 0.034 13.6 0.4 1.5 1 0 0 1 1 1 0 short chain dehydrogenase Ribul_P_3_epim PF00834.19 ACS98769.1 - 0.13 11.6 3.2 0.37 10.1 0.1 2.5 2 1 1 3 3 3 0 Ribulose-phosphate 3 epimerase family IGPS PF00218.21 ACS98769.1 - 0.15 11.2 0.2 1.4 8.1 0.0 2.4 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase Peptidase_S11 PF00768.20 ACS98770.1 - 6e-70 235.4 3.3 8.4e-70 234.9 3.3 1.2 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 ACS98770.1 - 4.7e-16 59.0 0.3 6.2e-16 58.6 0.3 1.3 1 0 0 1 1 1 1 Beta-lactamase enzyme family PBP5_C PF07943.13 ACS98770.1 - 2e-13 50.4 12.1 7.2e-13 48.6 10.8 2.3 2 0 0 2 2 2 1 Penicillin-binding protein 5, C-terminal domain SPRY PF00622.28 ACS98770.1 - 0.0031 17.6 0.0 0.0078 16.3 0.0 1.7 1 0 0 1 1 1 1 SPRY domain Beta-lactamase PF00144.24 ACS98770.1 - 0.011 15.1 0.0 0.061 12.6 0.0 2.0 1 1 0 2 2 2 0 Beta-lactamase BRCT PF00533.26 ACS98770.1 - 0.099 13.0 0.1 1.5 9.2 0.0 2.4 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain PsaM PF07465.13 ACS98770.1 - 2.4 8.0 7.8 0.079 12.7 1.1 2.0 2 0 0 2 2 2 0 Photosystem I protein M (PsaM) SOR_SNZ PF01680.17 ACS98771.1 - 6.5e-106 352.7 5.8 9.3e-106 352.2 5.8 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 ACS98771.1 - 5.5e-10 39.0 3.5 2.1e-07 30.5 0.0 2.3 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 ACS98771.1 - 0.00037 19.7 1.4 0.18 10.9 0.0 2.9 2 2 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.15 ACS98771.1 - 0.00038 20.0 6.0 0.0046 16.4 0.0 2.3 2 0 0 2 2 2 1 Nitronate monooxygenase NanE PF04131.14 ACS98771.1 - 0.0005 19.3 0.7 0.03 13.5 0.0 2.4 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.21 ACS98771.1 - 0.0026 17.0 0.0 0.13 11.5 0.0 2.5 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase His_biosynth PF00977.21 ACS98771.1 - 0.0038 16.7 0.4 0.1 12.1 0.0 2.5 2 0 0 2 2 2 1 Histidine biosynthesis protein TetR_C_27 PF17935.1 ACS98771.1 - 0.024 14.7 0.0 0.059 13.4 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF561 PF04481.12 ACS98771.1 - 0.024 13.8 0.3 1.7 7.8 0.3 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF561) SNO PF01174.19 ACS98772.1 - 9.3e-70 234.3 0.0 1.1e-69 234.1 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 ACS98772.1 - 1.6e-10 41.0 0.0 2.2e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 ACS98772.1 - 1.2e-08 34.9 0.0 1.7e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 GATase PF00117.28 ACS98772.1 - 2.4e-06 27.5 0.0 5.5e-06 26.3 0.0 1.6 1 1 0 1 1 1 1 Glutamine amidotransferase class-I DJ-1_PfpI PF01965.24 ACS98772.1 - 5.2e-06 26.4 0.1 1.5e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 DJ-1/PfpI family Peptidase_C26 PF07722.13 ACS98772.1 - 0.0023 17.7 0.1 0.034 13.9 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 tRNA-synt_2b PF00587.25 ACS98773.1 - 2.5e-35 122.0 0.0 3.8e-35 121.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ACS98773.1 - 2e-30 105.2 2.6 4.1e-30 104.2 2.6 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain tRNA-synt_His PF13393.6 ACS98773.1 - 0.045 13.0 0.7 0.18 11.1 0.0 2.0 2 0 0 2 2 2 0 Histidyl-tRNA synthetase BLOC1_2 PF10046.9 ACS98773.1 - 0.057 13.7 1.2 0.28 11.5 0.5 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LRRFIP PF09738.9 ACS98773.1 - 0.066 12.7 0.6 0.1 12.1 0.6 1.3 1 0 0 1 1 1 0 LRRFIP family DUF4201 PF13870.6 ACS98773.1 - 0.32 10.7 5.3 0.047 13.4 1.0 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) JIP_LZII PF16471.5 ACS98773.1 - 0.42 10.8 6.4 1.2 9.4 3.8 2.8 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II TMF_TATA_bd PF12325.8 ACS98773.1 - 1.2 9.4 5.1 2.9 8.2 1.7 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding GAS PF13851.6 ACS98773.1 - 4.3 6.6 6.1 0.31 10.4 0.2 2.0 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding SspP PF08179.12 ACS98776.1 - 1.6e-07 31.6 9.9 3.6e-07 30.5 9.9 1.6 1 1 0 1 1 1 1 Small acid-soluble spore protein P family Sec8_exocyst PF04048.14 ACS98777.1 - 0.0061 16.4 1.0 0.0061 16.4 1.0 1.7 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain FlpD PF02662.16 ACS98777.1 - 0.057 13.4 0.0 0.29 11.1 0.0 2.1 3 0 0 3 3 3 0 Methyl-viologen-reducing hydrogenase, delta subunit KapB PF08810.10 ACS98777.1 - 2.5 8.3 5.2 9.1 6.5 1.1 2.6 2 1 1 3 3 3 0 Kinase associated protein B DSBA PF01323.20 ACS98778.1 - 2.9e-48 164.2 0.1 3.9e-48 163.8 0.1 1.2 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 ACS98778.1 - 1.2e-12 48.4 0.2 2.3e-07 31.1 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.6 ACS98778.1 - 0.00016 21.7 0.0 0.0026 17.8 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_5 PF13743.6 ACS98778.1 - 0.0023 17.7 0.0 0.0051 16.5 0.0 1.6 1 1 1 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 ACS98778.1 - 0.11 12.9 0.4 1.3 9.5 0.4 2.2 1 1 0 1 1 1 0 Thioredoxin-like domain DNase_NucA_NucB PF14040.6 ACS98779.1 - 2.8e-13 50.3 0.0 3.9e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Deoxyribonuclease NucA/NucB DUF5602 PF18197.1 ACS98779.1 - 0.13 12.8 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5602) Glycos_transf_2 PF00535.26 ACS98780.1 - 7.8e-15 55.1 0.0 1.7e-14 54.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACS98780.1 - 4.8e-07 29.9 0.0 1.2e-06 28.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ACS98780.1 - 0.011 15.2 0.0 0.038 13.5 0.0 1.9 1 1 0 1 1 1 0 Glycosyl transferase family 21 ABC_tran PF00005.27 ACS98781.1 - 5.5e-35 120.9 0.0 7.9e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS98781.1 - 1.9e-05 24.7 0.0 0.002 18.0 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS98781.1 - 8.9e-05 22.0 0.3 0.00041 19.9 0.3 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACS98781.1 - 0.00075 19.8 0.4 0.004 17.4 0.4 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACS98781.1 - 0.022 14.5 0.1 0.042 13.6 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 ACS98781.1 - 0.024 14.8 0.0 0.049 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACS98781.1 - 0.064 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase BPD_transp_1 PF00528.22 ACS98782.1 - 3.9e-16 59.3 13.6 3.9e-16 59.3 13.6 1.6 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF4357 PF14267.6 ACS98782.1 - 0.17 11.8 1.1 12 6.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) DinB_2 PF12867.7 ACS98783.1 - 2.1e-18 67.1 0.0 2.5e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 DinB superfamily DUF664 PF04978.12 ACS98783.1 - 7.9e-07 29.6 0.0 9.7e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF664) DinB PF05163.12 ACS98783.1 - 7.1e-05 22.8 0.1 0.002 18.1 0.0 2.2 1 1 0 2 2 2 1 DinB family MDMPI_N PF11716.8 ACS98783.1 - 0.0056 17.4 0.0 0.0086 16.8 0.0 1.3 1 1 0 1 1 1 1 Mycothiol maleylpyruvate isomerase N-terminal domain Myosin_head PF00063.21 ACS98783.1 - 0.12 10.6 0.0 0.15 10.3 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) LMWPc PF01451.21 ACS98784.1 - 1.5e-06 28.7 0.1 0.0016 18.8 0.0 2.1 1 1 1 2 2 2 2 Low molecular weight phosphotyrosine protein phosphatase Ssu72 PF04722.13 ACS98784.1 - 0.0066 16.0 0.0 0.015 14.9 0.0 1.5 1 1 1 2 2 2 1 Ssu72-like protein Lactamase_B PF00753.27 ACS98785.1 - 6.6e-27 94.8 1.2 9.9e-27 94.2 1.2 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ACS98785.1 - 1.2e-06 28.2 0.1 2.4e-06 27.2 0.1 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 ACS98785.1 - 0.00037 20.0 0.0 0.00056 19.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain MafB19-deam PF14437.6 ACS98786.1 - 1.2e-45 154.7 0.0 1.3e-45 154.5 0.0 1.0 1 0 0 1 1 1 1 MafB19-like deaminase dCMP_cyt_deam_1 PF00383.23 ACS98786.1 - 8.1e-34 115.5 0.1 1.2e-33 115.0 0.1 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region SNAD4 PF18750.1 ACS98786.1 - 3.2e-05 24.0 0.4 0.0001 22.4 0.0 2.0 2 1 1 3 3 3 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 ACS98786.1 - 3.8e-05 23.8 0.2 0.003 17.7 0.0 2.7 2 1 1 3 3 3 1 APOBEC3 Bd3614-deam PF14439.6 ACS98786.1 - 0.00011 22.3 2.0 0.00037 20.6 0.4 2.1 1 1 1 2 2 2 1 Bd3614-like deaminase APOBEC2 PF18772.1 ACS98786.1 - 0.00028 21.0 0.0 0.00047 20.3 0.0 1.5 1 0 0 1 1 1 1 APOBEC2 NAD2 PF18782.1 ACS98786.1 - 0.00049 20.3 0.0 0.0012 19.0 0.0 1.6 1 1 0 1 1 1 1 Novel AID APOBEC clade 2 APOBEC_N PF08210.11 ACS98786.1 - 0.002 18.0 0.1 0.0031 17.4 0.1 1.5 1 1 0 1 1 1 1 APOBEC-like N-terminal domain NAD1 PF18778.1 ACS98786.1 - 0.0073 16.4 0.3 0.017 15.2 0.0 1.7 2 1 0 2 2 2 1 Novel AID APOBEC clade 1 Lar_restr_allev PF14354.6 ACS98786.1 - 0.11 12.9 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 Restriction alleviation protein Lar DUF4191 PF13829.6 ACS98786.1 - 0.13 11.6 0.1 2.3 7.5 0.0 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4191) HATPase_c PF02518.26 ACS98787.1 - 3.1e-22 79.2 0.6 8.4e-22 77.8 0.6 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 ACS98787.1 - 3.3e-14 53.0 0.0 1e-13 51.4 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 ACS98787.1 - 1.9e-13 50.6 0.0 4.3e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 ACS98787.1 - 2e-13 50.3 0.1 1.9e-12 47.1 0.1 2.4 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 ACS98787.1 - 1.8e-11 43.8 0.0 6e-11 42.1 0.0 1.9 1 0 0 1 1 1 1 PAS domain HisKA PF00512.25 ACS98787.1 - 2.9e-11 43.2 2.2 3.4e-11 43.0 0.1 2.3 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACS98787.1 - 8.5e-08 32.5 0.0 3.2e-07 30.6 0.0 2.1 1 0 0 1 1 1 1 HAMP domain PAS_3 PF08447.12 ACS98787.1 - 3.6e-06 27.2 0.0 8.3e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 PAS fold HATPase_c_5 PF14501.6 ACS98787.1 - 0.00054 19.8 0.4 0.0013 18.6 0.4 1.6 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 ACS98787.1 - 0.0012 18.8 0.0 0.0096 15.9 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-like ATPase domain PAS_7 PF12860.7 ACS98787.1 - 0.016 15.4 0.4 0.13 12.5 0.0 2.8 3 1 0 3 3 2 0 PAS fold CREPT PF16566.5 ACS98787.1 - 0.028 14.6 0.3 0.12 12.6 0.1 2.1 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour HATPase_c_3 PF13589.6 ACS98787.1 - 0.051 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4446 PF14584.6 ACS98787.1 - 0.08 12.9 0.2 0.56 10.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) NAD_binding_10 PF13460.6 ACS98788.1 - 3e-09 37.0 0.0 5.3e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ACS98788.1 - 3.4e-09 36.5 0.0 1e-08 35.0 0.0 1.7 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family HIM1 PF08732.10 ACS98788.1 - 3.7e-07 29.8 0.0 6.1e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 HIM1 NAD_binding_4 PF07993.12 ACS98788.1 - 0.00022 20.5 0.0 0.00072 18.8 0.0 1.9 2 0 0 2 2 2 1 Male sterility protein Semialdhyde_dh PF01118.24 ACS98788.1 - 0.0026 18.2 0.0 0.0088 16.5 0.0 1.8 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 ACS98788.1 - 0.024 14.7 0.0 0.11 12.6 0.0 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.19 ACS98788.1 - 0.034 13.2 0.0 0.15 11.0 0.0 1.8 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ACS98788.1 - 0.043 12.9 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 ACS98788.1 - 0.046 13.1 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase PseudoU_synth_2 PF00849.22 ACS98789.1 - 2.2e-15 57.1 0.1 8.7e-14 51.9 0.1 2.2 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 ACS98789.1 - 8.2e-11 41.4 0.0 8.1e-10 38.3 0.0 2.4 1 1 1 2 2 2 1 S4 domain MotB_plug PF13677.6 ACS98790.1 - 1.9e-20 72.2 0.4 3.8e-20 71.2 0.4 1.6 1 0 0 1 1 1 1 Membrane MotB of proton-channel complex MotA/MotB OmpA PF00691.20 ACS98790.1 - 3.7e-18 65.7 0.9 9.7e-18 64.3 0.0 2.0 2 0 0 2 2 2 1 OmpA family FliD_N PF02465.18 ACS98790.1 - 0.024 15.3 2.4 0.064 14.0 2.4 1.7 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Prominin PF05478.11 ACS98790.1 - 0.024 12.6 1.5 0.03 12.3 1.5 1.1 1 0 0 1 1 1 0 Prominin Exonuc_VII_L PF02601.15 ACS98790.1 - 0.05 13.2 1.1 0.06 12.9 1.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TetR_C_2 PF08361.11 ACS98790.1 - 0.054 13.6 0.2 0.093 12.8 0.2 1.4 1 0 0 1 1 1 0 MAATS-type transcriptional repressor, C-terminal region ANTH PF07651.16 ACS98790.1 - 0.069 12.1 0.8 0.12 11.4 0.8 1.3 1 0 0 1 1 1 0 ANTH domain MotA_ExbB PF01618.16 ACS98791.1 - 1e-27 96.4 0.1 1e-27 96.4 0.1 2.5 2 1 1 3 3 3 1 MotA/TolQ/ExbB proton channel family DsbD_2 PF13386.6 ACS98791.1 - 0.09 12.7 7.8 0.37 10.7 0.8 2.2 2 0 0 2 2 2 0 Cytochrome C biogenesis protein transmembrane region BCLP PF12304.8 ACS98791.1 - 0.22 11.0 7.6 1.6 8.3 0.2 2.4 2 0 0 2 2 2 0 Beta-casein like protein TssN PF17555.2 ACS98791.1 - 2.2 7.6 5.0 3.3 7.0 0.2 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssN FUSC_2 PF13515.6 ACS98791.1 - 6 7.0 12.0 2.6 8.2 1.8 2.7 2 1 0 2 2 2 0 Fusaric acid resistance protein-like Phage_holin_3_6 PF07332.11 ACS98791.1 - 6.7 6.8 9.3 13 5.8 0.2 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III EAL PF00563.20 ACS98793.1 - 5.5e-40 137.4 0.0 1e-39 136.5 0.0 1.4 1 0 0 1 1 1 1 EAL domain YkuI_C PF10388.9 ACS98793.1 - 1e-29 103.5 0.5 1.5e-29 102.9 0.5 1.2 1 0 0 1 1 1 1 EAL-domain associated signalling protein domain Mago-bind PF09282.10 ACS98793.1 - 0.024 14.5 0.3 0.06 13.2 0.3 1.7 1 0 0 1 1 1 0 Mago binding Acetyltransf_1 PF00583.25 ACS98794.1 - 2.1e-10 40.9 0.0 4.2e-10 39.9 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 ACS98794.1 - 1.1e-07 32.6 0.0 1.3e-07 32.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACS98794.1 - 0.0002 21.7 0.0 0.00032 21.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ACS98794.1 - 0.00028 20.6 0.0 0.00047 19.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACS98794.1 - 0.007 16.3 0.0 0.0093 15.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MFS_1 PF07690.16 ACS98795.1 - 5.4e-29 101.2 50.2 5.8e-27 94.5 41.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ACS98795.1 - 2.8e-06 26.9 29.7 0.00016 21.1 29.7 2.1 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB NLPC_P60 PF00877.19 ACS98796.1 - 2.8e-32 110.9 0.1 3.5e-32 110.5 0.1 1.1 1 0 0 1 1 1 1 NlpC/P60 family LRAT PF04970.13 ACS98796.1 - 0.0024 18.2 0.1 0.0038 17.5 0.1 1.3 1 1 0 1 1 1 1 Lecithin retinol acyltransferase CHAP PF05257.16 ACS98796.1 - 0.0031 18.0 0.0 0.005 17.4 0.0 1.3 1 0 0 1 1 1 1 CHAP domain Peptidase_C92 PF05708.12 ACS98796.1 - 0.0042 17.2 0.0 0.087 12.9 0.0 2.2 1 1 1 2 2 2 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Amidase_6 PF12671.7 ACS98796.1 - 0.019 15.0 0.1 0.032 14.3 0.1 1.4 1 1 0 1 1 1 0 Putative amidase domain Peptidase_M1 PF01433.20 ACS98798.1 - 3.6e-16 59.4 3.1 1e-15 57.9 3.1 1.7 1 1 0 1 1 1 1 Peptidase family M1 domain DUF2268 PF10026.9 ACS98798.1 - 0.0047 16.5 0.2 0.3 10.6 0.0 2.3 2 0 0 2 2 2 2 Predicted Zn-dependent protease (DUF2268) Peptidase_MA_2 PF13485.6 ACS98798.1 - 0.094 12.4 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase MA superfamily YwhD PF08741.10 ACS98799.1 - 2.6e-70 235.3 0.5 3e-70 235.1 0.5 1.0 1 0 0 1 1 1 1 YwhD family SieB PF14163.6 ACS98799.1 - 0.22 11.0 0.1 0.34 10.4 0.1 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B Sigma70_r2 PF04542.14 ACS98800.1 - 1.9e-17 62.8 2.5 6e-17 61.2 0.2 2.3 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACS98800.1 - 3.8e-15 55.3 0.1 7.9e-15 54.3 0.1 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACS98800.1 - 6.3e-05 22.9 0.2 0.00027 20.9 0.4 1.9 2 0 0 2 2 2 1 ECF sigma factor Sigma70_r4 PF04545.16 ACS98800.1 - 8.8e-05 22.0 0.1 0.00018 21.0 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Phage_antitermQ PF06530.12 ACS98800.1 - 0.0097 15.8 0.2 0.02 14.8 0.2 1.5 1 0 0 1 1 1 1 Phage antitermination protein Q HTH_40 PF14493.6 ACS98800.1 - 0.036 14.5 0.3 0.83 10.1 0.0 2.7 2 2 1 3 3 3 0 Helix-turn-helix domain GHMP_kinases_C PF08544.13 ACS98800.1 - 0.082 13.3 0.0 1.1 9.7 0.0 2.2 2 0 0 2 2 2 0 GHMP kinases C terminal zf-HC2 PF13490.6 ACS98801.1 - 0.00012 22.2 3.6 0.00022 21.4 3.6 1.4 1 0 0 1 1 1 1 Putative zinc-finger TM2 PF05154.16 ACS98802.1 - 4.3 7.7 43.1 0.16 12.3 0.6 6.3 7 0 0 7 7 7 0 TM2 domain NnrS PF05940.12 ACS98803.1 - 0.0058 16.1 1.0 0.008 15.6 1.0 1.1 1 0 0 1 1 1 1 NnrS protein EI24 PF07264.11 ACS98803.1 - 0.039 14.2 1.3 0.052 13.8 1.3 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) ETX_MTX2 PF03318.13 ACS98803.1 - 0.057 13.2 0.1 0.079 12.7 0.1 1.1 1 0 0 1 1 1 0 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 DUF2583 PF10762.9 ACS98803.1 - 0.24 11.8 2.2 0.52 10.8 2.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2583) Pro_isomerase PF00160.21 ACS98804.1 - 8.1e-50 169.2 0.1 1.1e-49 168.7 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD COX4_pro PF03626.14 ACS98805.1 - 5.5e-19 68.4 11.3 7e-19 68.0 11.3 1.1 1 0 0 1 1 1 1 Prokaryotic Cytochrome C oxidase subunit IV DUF2157 PF09925.9 ACS98805.1 - 0.0012 18.7 0.4 0.0015 18.4 0.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2157) BT1 PF03092.16 ACS98805.1 - 0.0015 16.8 1.3 0.0017 16.7 0.2 1.5 1 1 1 2 2 2 1 BT1 family Polysacc_synt PF01943.17 ACS98805.1 - 0.002 17.5 4.4 0.0022 17.4 4.4 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein YwiC PF14256.6 ACS98805.1 - 0.0025 18.1 3.4 0.0041 17.4 3.4 1.3 1 1 0 1 1 1 1 YwiC-like protein DUF1761 PF08570.10 ACS98805.1 - 0.007 16.6 3.4 0.011 16.0 3.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1761) ESSS PF10183.9 ACS98805.1 - 0.073 13.3 0.7 1.3 9.3 0.0 2.1 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) DUF898 PF05987.13 ACS98805.1 - 0.19 10.8 8.1 0.27 10.2 2.2 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) PEN-2 PF10251.9 ACS98805.1 - 0.27 11.7 2.6 1.8 9.0 1.7 2.0 2 0 0 2 2 2 0 Presenilin enhancer-2 subunit of gamma secretase DUF5326 PF17260.2 ACS98805.1 - 0.44 10.7 16.4 1.7 8.9 0.9 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5326) DUF3290 PF11694.8 ACS98805.1 - 0.54 10.2 9.1 0.12 12.3 4.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3290) SUR7 PF06687.12 ACS98805.1 - 0.55 9.8 11.9 0.38 10.4 5.5 2.0 1 1 1 2 2 2 0 SUR7/PalI family UPF0182 PF03699.13 ACS98805.1 - 1.2 7.2 5.9 1.3 7.0 5.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Deltameth_res PF16020.5 ACS98805.1 - 1.8 8.5 3.9 1.1 9.2 0.2 2.4 2 1 1 3 3 3 0 Deltamethrin resistance DUF4870 PF09685.10 ACS98805.1 - 2.2 8.4 12.5 0.06 13.5 4.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4870) COX3 PF00510.18 ACS98806.1 - 2.9e-17 63.4 17.3 6e-17 62.3 17.3 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase subunit III DUF5542 PF17696.1 ACS98806.1 - 2.7 8.2 4.3 2.4 8.3 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5542) COX1 PF00115.20 ACS98807.1 - 2.3e-145 484.7 69.4 2.3e-145 484.7 69.4 2.0 2 0 0 2 2 2 1 Cytochrome C and Quinol oxidase polypeptide I COX_ARM PF06481.14 ACS98808.1 - 5.9e-08 32.5 0.1 9.8e-08 31.8 0.1 1.4 1 0 0 1 1 1 1 COX Aromatic Rich Motif COX2 PF00116.20 ACS98808.1 - 1e-06 28.6 0.0 1.9e-05 24.5 0.0 2.4 1 1 1 2 2 2 1 Cytochrome C oxidase subunit II, periplasmic domain COX2_TM PF02790.15 ACS98808.1 - 3.9e-06 26.9 3.3 3.9e-06 26.9 3.3 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain Sulf_transp PF04143.14 ACS98808.1 - 0.0072 15.9 0.9 0.0072 15.9 0.9 1.5 1 1 1 2 2 2 1 Sulphur transport LMBR1 PF04791.16 ACS98808.1 - 0.029 13.3 1.0 0.041 12.8 1.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4199 PF13858.6 ACS98808.1 - 0.03 14.7 0.1 0.1 13.0 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) DUF4131 PF13567.6 ACS98808.1 - 0.059 13.0 0.1 0.059 13.0 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF3671 PF12420.8 ACS98808.1 - 0.96 9.6 3.8 0.3 11.2 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF2975 PF11188.8 ACS98809.1 - 0.015 15.2 0.4 0.017 15.0 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) E1-E2_ATPase PF00122.20 ACS98809.1 - 0.03 13.8 1.1 0.035 13.6 1.1 1.1 1 0 0 1 1 1 0 E1-E2 ATPase DUF1772 PF08592.11 ACS98809.1 - 0.05 13.9 0.0 0.056 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) DUF1461 PF07314.11 ACS98809.1 - 0.19 11.6 1.2 0.22 11.4 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) Transgly PF00912.22 ACS98810.1 - 6.8e-66 221.1 1.1 1.2e-65 220.3 1.1 1.4 1 0 0 1 1 1 1 Transglycosylase Transpeptidase PF00905.22 ACS98810.1 - 3.5e-36 125.0 1.0 1.3e-34 119.9 1.0 2.8 2 1 0 2 2 2 1 Penicillin binding protein transpeptidase domain IlvB_leader PF08049.11 ACS98810.1 - 0.11 12.5 0.2 0.28 11.1 0.2 1.6 1 0 0 1 1 1 0 IlvB leader peptide Spermine_synth PF01564.17 ACS98811.1 - 1.9e-67 226.3 0.1 2.7e-67 225.8 0.1 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 ACS98811.1 - 8.7e-16 57.6 1.0 1.9e-15 56.5 1.0 1.6 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_31 PF13847.6 ACS98811.1 - 2e-05 24.4 0.0 6.2e-05 22.8 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACS98811.1 - 5.3e-05 23.8 0.0 9.7e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACS98811.1 - 0.007 17.1 0.0 0.02 15.6 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain DRE2_N PF16803.5 ACS98811.1 - 0.0087 16.3 0.0 0.029 14.6 0.0 1.8 2 0 0 2 2 2 1 Fe-S cluster assembly protein DRE2 N-terminus Robl_LC7 PF03259.17 ACS98811.1 - 0.093 12.5 0.0 0.61 9.9 0.0 2.2 2 0 0 2 2 2 0 Roadblock/LC7 domain UDG PF03167.19 ACS98812.1 - 1.6e-06 28.2 0.0 2.3e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily DUF1934 PF09148.10 ACS98813.1 - 1.2e-25 90.0 0.0 1.5e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1934) DALR_1 PF05746.15 ACS98814.1 - 2.8e-36 124.3 0.1 6.3e-36 123.2 0.1 1.6 1 0 0 1 1 1 1 DALR anticodon binding domain tRNA-synt_1d PF00750.19 ACS98814.1 - 1.5e-28 99.8 0.1 3.9e-28 98.4 0.1 1.6 1 1 0 1 1 1 1 tRNA synthetases class I (R) Arg_tRNA_synt_N PF03485.16 ACS98814.1 - 9.3e-27 93.4 1.2 4.3e-24 84.9 0.8 2.6 2 0 0 2 2 2 2 Arginyl tRNA synthetase N terminal domain tRNA-synt_1 PF00133.22 ACS98814.1 - 8.4e-08 30.9 0.1 0.00027 19.3 0.1 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ACS98814.1 - 1.6e-07 30.4 1.6 0.00074 18.4 0.1 4.0 3 1 1 4 4 4 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ACS98814.1 - 2.3e-07 30.5 0.0 0.0075 15.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 ACS98814.1 - 6.2e-06 25.4 0.1 0.0011 18.0 0.0 3.0 3 0 0 3 3 3 1 tRNA synthetases class I (K) tRNA-synt_1b PF00579.25 ACS98814.1 - 0.013 14.9 0.0 0.61 9.4 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) Ceramidse_alk_C PF17048.5 ACS98814.1 - 0.087 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Neutral/alkaline non-lysosomal ceramidase, C-terminal Peptidase_S8 PF00082.22 ACS98815.1 - 1.1e-54 185.7 0.5 2.3e-54 184.7 0.5 1.5 1 1 0 1 1 1 1 Subtilase family HARE-HTH PF05066.13 ACS98816.1 - 4.1e-05 23.9 0.0 6e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain DUF4777 PF16007.5 ACS98816.1 - 0.023 15.0 0.0 0.046 14.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4777) BUD22 PF09073.10 ACS98816.1 - 1.9 7.7 21.4 2.1 7.6 21.4 1.1 1 0 0 1 1 1 0 BUD22 CTP_synth_N PF06418.14 ACS98817.1 - 1.8e-131 437.3 1.6 2.3e-131 436.9 1.6 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 ACS98817.1 - 2.1e-59 200.5 0.0 3.9e-59 199.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ACS98817.1 - 7e-10 39.0 0.4 8.8e-08 32.2 0.1 3.1 2 1 0 2 2 2 1 Peptidase C26 CbiA PF01656.23 ACS98817.1 - 0.004 17.2 0.0 0.009 16.1 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Asp_Glu_race PF01177.22 ACS98817.1 - 0.041 13.7 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 Asp/Glu/Hydantoin racemase Response_reg PF00072.24 ACS98818.1 - 4.1e-29 101.0 1.0 4.6e-29 100.8 1.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain EPSP_synthase PF00275.20 ACS98819.1 - 1.3e-89 300.8 2.2 1.6e-89 300.5 2.2 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Sigma70_r1_1 PF03979.14 ACS98819.1 - 0.12 12.4 0.0 0.91 9.6 0.1 2.4 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 Rho_RNA_bind PF07497.12 ACS98820.1 - 1.2e-30 105.2 0.0 2.5e-30 104.1 0.0 1.6 1 0 0 1 1 1 1 Rho termination factor, RNA-binding domain ATP-synt_ab PF00006.25 ACS98820.1 - 5.6e-18 65.4 0.0 9.2e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Rho_N PF07498.12 ACS98820.1 - 1.5e-16 60.1 2.1 3.6e-16 58.8 2.1 1.7 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain OB_RNB PF08206.11 ACS98820.1 - 0.0016 18.1 0.0 0.0033 17.1 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease B OB domain AAA PF00004.29 ACS98820.1 - 0.0023 18.3 0.1 0.0082 16.6 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ACS98820.1 - 0.0087 16.0 0.1 0.017 15.0 0.1 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 ACS98820.1 - 0.02 14.8 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 ACS98820.1 - 0.041 14.1 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ACS98820.1 - 0.047 13.3 0.1 0.12 11.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ACS98820.1 - 0.15 12.4 0.2 1.2 9.5 0.2 2.2 1 1 0 1 1 1 0 AAA ATPase domain Radical_SAM PF04055.21 ACS98821.1 - 1.5e-12 48.2 0.0 2.5e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Cellulase PF00150.18 ACS98821.1 - 0.023 14.1 0.1 0.034 13.6 0.1 1.2 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) NiFe_hyd_SSU_C PF14720.6 ACS98821.1 - 0.12 12.8 0.6 0.28 11.6 0.3 1.7 2 0 0 2 2 2 0 NiFe/NiFeSe hydrogenase small subunit C-terminal Fer4_14 PF13394.6 ACS98821.1 - 0.17 12.0 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain Ribosomal_L31 PF01197.18 ACS98822.1 - 3.2e-31 107.3 0.4 3.6e-31 107.2 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L31 Spore_YhcN_YlaJ PF09580.10 ACS98823.1 - 0.00023 21.3 0.2 0.00028 21.0 0.2 1.1 1 0 0 1 1 1 1 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HMA PF00403.26 ACS98823.1 - 0.12 12.8 0.1 0.2 12.1 0.1 1.3 1 0 0 1 1 1 0 Heavy-metal-associated domain DNA_pol3_delta2 PF13177.6 ACS98824.1 - 2.7e-49 167.1 0.0 8.7e-49 165.4 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA PF00004.29 ACS98824.1 - 2.5e-14 53.8 0.0 6.3e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_gamma3 PF12169.8 ACS98824.1 - 7.8e-10 38.8 0.1 1.8e-09 37.6 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase III subunits gamma and tau domain III RuvB_N PF05496.12 ACS98824.1 - 5e-07 29.6 0.2 1.1e-05 25.3 0.0 2.4 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ACS98824.1 - 9.6e-07 28.3 0.0 0.03 13.5 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_30 PF13604.6 ACS98824.1 - 3.7e-06 26.8 0.0 1.8e-05 24.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ACS98824.1 - 1.4e-05 25.2 0.0 5.8e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ACS98824.1 - 7.9e-05 23.1 0.4 0.0015 18.9 0.0 3.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ACS98824.1 - 0.00014 22.1 0.0 0.0022 18.3 0.0 2.6 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 ACS98824.1 - 0.00067 19.7 0.2 1.6 8.7 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ACS98824.1 - 0.00076 19.8 0.2 0.032 14.6 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ACS98824.1 - 0.0016 18.2 0.0 0.015 15.0 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 ACS98824.1 - 0.0017 18.9 0.0 0.019 15.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ACS98824.1 - 0.0025 17.3 0.0 1.4 8.4 0.0 2.9 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_assoc_2 PF16193.5 ACS98824.1 - 0.0029 17.9 0.1 0.0089 16.4 0.1 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_14 PF13173.6 ACS98824.1 - 0.003 17.6 0.0 0.021 14.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 ACS98824.1 - 0.0039 17.1 0.0 0.0081 16.1 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain PIF1 PF05970.14 ACS98824.1 - 0.004 16.4 0.0 0.0074 15.5 0.0 1.4 1 0 0 1 1 1 1 PIF1-like helicase T2SSE PF00437.20 ACS98824.1 - 0.044 12.8 0.0 0.15 11.1 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein Mg_chelatase PF01078.21 ACS98824.1 - 0.053 12.9 0.0 0.17 11.2 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI HrpJ PF07201.11 ACS98824.1 - 0.059 13.7 0.3 0.21 11.9 0.0 2.0 2 0 0 2 2 2 0 HrpJ-like domain TniB PF05621.11 ACS98824.1 - 0.066 12.6 0.0 0.38 10.1 0.0 2.0 1 1 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 ACS98824.1 - 0.074 13.6 0.0 0.23 12.0 0.0 1.9 1 0 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.26 ACS98824.1 - 0.083 12.6 0.0 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain Glyco_tranf_2_5 PF13712.6 ACS98824.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family RNA_helicase PF00910.22 ACS98824.1 - 0.11 12.9 0.0 0.45 10.9 0.0 2.0 2 0 0 2 2 1 0 RNA helicase TsaE PF02367.17 ACS98824.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ACS98824.1 - 0.14 12.3 0.0 0.46 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain YbaB_DNA_bd PF02575.16 ACS98825.1 - 2.6e-34 117.3 8.1 3.1e-34 117.1 8.1 1.1 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family SIS_2 PF13580.6 ACS98825.1 - 0.0091 16.0 0.1 0.01 15.8 0.1 1.1 1 0 0 1 1 1 1 SIS domain RVT_N PF13655.6 ACS98825.1 - 0.021 15.1 0.4 1.2 9.5 0.3 2.1 2 0 0 2 2 2 0 N-terminal domain of reverse transcriptase DUF2680 PF10925.8 ACS98825.1 - 0.024 14.7 2.8 0.05 13.6 2.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) ATP-grasp_4 PF13535.6 ACS98825.1 - 0.053 13.1 0.2 0.058 13.0 0.2 1.1 1 0 0 1 1 1 0 ATP-grasp domain DUF3138 PF11336.8 ACS98825.1 - 0.078 11.6 0.3 0.08 11.6 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) LIN52 PF10044.9 ACS98825.1 - 0.08 13.7 3.2 1.5 9.5 0.0 2.1 1 1 1 2 2 2 0 Retinal tissue protein CBFD_NFYB_HMF PF00808.23 ACS98825.1 - 0.22 11.8 4.4 3.2 8.1 2.4 2.1 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Toprim_4 PF13662.6 ACS98826.1 - 1.5e-23 83.1 0.0 2.4e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 Toprim domain RecR PF02132.15 ACS98826.1 - 6e-16 57.7 5.3 1.1e-15 56.9 5.3 1.5 1 0 0 1 1 1 1 RecR protein Toprim PF01751.22 ACS98826.1 - 1.8e-07 31.3 0.0 3.6e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Toprim domain HHH_5 PF14520.6 ACS98826.1 - 0.0026 18.3 0.2 0.03 14.9 0.0 2.4 2 1 0 2 2 2 1 Helix-hairpin-helix domain HHH_8 PF14716.6 ACS98826.1 - 0.0059 17.0 0.0 0.028 14.8 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH PF00633.23 ACS98826.1 - 0.011 15.5 0.0 0.011 15.5 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif IMS_HHH PF11798.8 ACS98826.1 - 0.055 13.8 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif DUF2508 PF10704.9 ACS98827.1 - 2.3e-08 34.1 0.3 3.8e-08 33.4 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2508) DotU PF09850.9 ACS98827.1 - 0.035 13.8 0.0 0.048 13.4 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system protein DotU BofA PF07441.11 ACS98828.1 - 1.8e-14 53.7 10.4 2.3e-14 53.4 10.4 1.2 1 1 0 1 1 1 1 SigmaK-factor processing regulatory protein BofA ThrE PF06738.12 ACS98828.1 - 0.00057 19.3 7.2 0.00062 19.2 7.2 1.0 1 0 0 1 1 1 1 Putative threonine/serine exporter MASE3 PF17159.4 ACS98828.1 - 0.057 13.0 5.2 0.059 13.0 5.2 1.1 1 0 0 1 1 1 0 Membrane-associated sensor domain FMN_red PF03358.15 ACS98829.1 - 7e-29 100.6 0.0 9.6e-29 100.1 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ACS98829.1 - 1e-07 31.9 0.0 1.6e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold F420_oxidored PF03807.17 ACS98829.1 - 0.034 14.7 0.0 0.073 13.7 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Flavodoxin_5 PF12724.7 ACS98829.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.6 1 1 0 1 1 1 0 Flavodoxin domain Glycos_transf_4 PF00953.21 ACS98830.1 - 1.1e-34 119.7 17.1 1.1e-34 119.7 17.1 2.2 3 0 0 3 3 3 1 Glycosyl transferase family 4 HTH_30 PF13556.6 ACS98831.1 - 1.6e-18 66.2 0.5 2.9e-18 65.4 0.5 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_8 PF02954.19 ACS98831.1 - 0.00036 20.2 0.4 0.0071 16.1 0.0 3.0 3 0 0 3 3 3 1 Bacterial regulatory protein, Fis family ABC_tran PF00005.27 ACS98832.1 - 3.4e-29 102.1 0.0 7.6e-29 101.0 0.0 1.6 2 0 0 2 2 1 1 ABC transporter OB_MalK PF17912.1 ACS98832.1 - 2e-15 57.4 0.0 1e-14 55.1 0.0 2.3 2 0 0 2 2 1 1 MalK OB fold domain TOBE_2 PF08402.10 ACS98832.1 - 2.6e-06 27.5 0.0 6.2e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 TOBE domain AAA_21 PF13304.6 ACS98832.1 - 7e-06 26.1 0.0 0.02 14.7 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS98832.1 - 8.1e-06 25.4 0.0 1.4e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 ACS98832.1 - 1.3e-05 25.3 0.0 1.9e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain CysA_C_terminal PF17850.1 ACS98832.1 - 5.4e-05 23.7 0.0 0.00026 21.5 0.0 2.2 2 0 0 2 2 2 1 CysA C-terminal regulatory domain TOBE PF03459.17 ACS98832.1 - 6.7e-05 23.1 0.0 0.00097 19.4 0.0 2.8 3 1 0 3 3 2 1 TOBE domain AAA_22 PF13401.6 ACS98832.1 - 0.00023 21.5 0.0 0.00038 20.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACS98832.1 - 0.0021 18.0 0.0 0.0055 16.6 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_15 PF13175.6 ACS98832.1 - 0.0034 17.2 0.0 0.0091 15.7 0.0 1.6 1 1 0 2 2 2 1 AAA ATPase domain AAA_16 PF13191.6 ACS98832.1 - 0.0036 17.7 0.2 0.0088 16.4 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain ZU5 PF00791.20 ACS98832.1 - 0.0091 16.3 0.0 0.018 15.4 0.0 1.6 1 0 0 1 1 1 1 ZU5 domain AAA_18 PF13238.6 ACS98832.1 - 0.01 16.3 0.0 0.023 15.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ACS98832.1 - 0.016 15.6 0.0 0.15 12.5 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ACS98832.1 - 0.02 14.6 0.0 0.055 13.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ACS98832.1 - 0.038 14.5 0.1 0.13 12.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ACS98832.1 - 0.054 13.2 0.0 0.084 12.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ACS98832.1 - 0.075 12.9 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 ACS98832.1 - 0.11 12.6 0.0 0.46 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ACS98832.1 - 0.16 12.4 0.0 0.53 10.7 0.0 1.9 2 0 0 2 2 2 0 RNA helicase Sigma70_r2 PF04542.14 ACS98833.1 - 7.9e-15 54.4 0.8 2.8e-14 52.6 0.6 1.8 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACS98833.1 - 3.3e-14 52.3 0.1 7.3e-14 51.2 0.1 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACS98833.1 - 1.2e-11 44.0 0.1 2.3e-11 43.0 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 ACS98833.1 - 0.0073 16.1 0.1 0.0073 16.1 0.1 2.0 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 ACS98833.1 - 0.016 15.3 0.6 0.25 11.5 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain MerR_1 PF13411.6 ACS98833.1 - 0.043 13.9 0.4 0.49 10.5 0.0 2.4 2 0 0 2 2 2 0 MerR HTH family regulatory protein HTH_29 PF13551.6 ACS98833.1 - 0.061 13.3 0.0 0.17 11.9 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn helix HrcA_DNA-bdg PF03444.15 ACS98833.1 - 0.083 12.6 0.0 0.21 11.3 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding DUF5643 PF18705.1 ACS98834.1 - 7.7e-22 77.4 1.0 7.9e-14 51.6 0.0 3.2 2 1 1 3 3 3 3 Family of unknown function (DUF5643) DUF4179 PF13786.6 ACS98834.1 - 1.2e-20 73.8 0.2 3.3e-20 72.3 0.0 1.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4179) DUF3040 PF11239.8 ACS98834.1 - 0.16 12.3 0.3 0.34 11.2 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Hpr_kinase_C PF07475.12 ACS98835.1 - 1.3e-77 259.2 0.3 2e-77 258.6 0.3 1.3 1 0 0 1 1 1 1 HPr Serine kinase C-terminal domain Hpr_kinase_N PF02603.16 ACS98835.1 - 3.7e-39 133.6 0.0 5.7e-39 133.0 0.0 1.3 1 0 0 1 1 1 1 HPr Serine kinase N terminus AAA_28 PF13521.6 ACS98835.1 - 0.0037 17.5 0.1 0.01 16.1 0.1 1.8 1 1 0 1 1 1 1 AAA domain DRTGG PF07085.12 ACS98835.1 - 0.024 14.4 0.5 0.058 13.2 0.0 1.9 3 0 0 3 3 3 0 DRTGG domain AAA_16 PF13191.6 ACS98835.1 - 0.073 13.4 0.4 2.3 8.6 0.2 2.2 1 1 1 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 ACS98835.1 - 0.16 11.7 0.5 0.4 10.5 0.3 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain LGT PF01790.18 ACS98836.1 - 3.6e-68 229.4 14.1 4.7e-68 229.0 14.1 1.1 1 0 0 1 1 1 1 Prolipoprotein diacylglyceryl transferase Transgly_assoc PF04226.13 ACS98836.1 - 0.0055 16.9 7.7 0.45 10.8 0.1 3.9 3 0 0 3 3 3 2 Transglycosylase associated protein HAD_2 PF13419.6 ACS98837.1 - 1.9e-45 155.1 0.0 2.3e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACS98837.1 - 3.3e-18 66.8 0.1 1.3e-15 58.3 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACS98837.1 - 5.1e-10 39.3 0.0 8.8e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ACS98837.1 - 9.2e-08 32.7 0.0 1.3e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ACS98837.1 - 0.0082 15.9 0.1 6.3 6.4 0.0 3.0 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hexapep PF00132.24 ACS98838.1 - 2.1e-16 58.9 6.0 2.2e-12 46.2 3.8 2.5 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACS98838.1 - 1.7e-14 53.2 8.1 7.7e-13 48.0 2.4 2.9 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 ACS98838.1 - 0.06 11.5 0.2 0.074 11.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) tRNA-synt_His PF13393.6 ACS98839.1 - 2.3e-79 266.9 0.1 3e-79 266.5 0.1 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2d PF01409.20 ACS98839.1 - 0.00027 20.5 0.0 0.00044 19.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 ACS98839.1 - 0.0045 17.0 0.0 0.015 15.3 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HisG PF01634.18 ACS98840.1 - 1.5e-51 174.5 0.0 2.5e-51 173.8 0.0 1.3 2 0 0 2 2 2 1 ATP phosphoribosyltransferase Histidinol_dh PF00815.20 ACS98841.1 - 1e-172 574.8 3.8 1.2e-172 574.6 3.8 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase Imm21 PF15589.6 ACS98841.1 - 0.16 12.0 0.3 0.3 11.1 0.3 1.4 1 0 0 1 1 1 0 Immunity protein 21 IGPD PF00475.18 ACS98842.1 - 5.1e-63 211.7 0.3 6.2e-63 211.4 0.3 1.1 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Asp23 PF03780.13 ACS98842.1 - 0.086 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Asp23 family, cell envelope-related function GATase PF00117.28 ACS98843.1 - 2e-21 76.6 0.0 2.3e-21 76.4 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 ACS98843.1 - 7.6e-08 32.2 0.0 7.6e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 ACS98843.1 - 1.2e-06 28.5 0.1 9.9e-06 25.5 0.1 2.2 1 1 0 1 1 1 1 SNO glutamine amidotransferase family Peptidase_C26 PF07722.13 ACS98843.1 - 0.0001 22.2 0.4 0.00074 19.3 0.4 2.1 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 ACS98843.1 - 0.0017 18.2 0.0 0.0026 17.6 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family His_biosynth PF00977.21 ACS98844.1 - 8.2e-90 300.3 1.4 9.3e-90 300.1 1.4 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein NMO PF03060.15 ACS98844.1 - 3.7e-06 26.6 2.3 0.0047 16.4 0.1 2.1 2 0 0 2 2 2 2 Nitronate monooxygenase TMP-TENI PF02581.17 ACS98844.1 - 8.9e-05 21.9 0.3 0.034 13.5 0.1 2.3 2 0 0 2 2 2 2 Thiamine monophosphate synthase Dus PF01207.17 ACS98844.1 - 0.00023 20.4 0.1 0.0041 16.3 0.0 2.1 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 ACS98844.1 - 0.0012 18.1 0.4 0.53 9.4 0.2 2.3 2 1 0 2 2 2 2 Dihydroorotate dehydrogenase G3P_antiterm PF04309.12 ACS98844.1 - 0.0033 16.9 0.3 0.021 14.2 0.2 2.0 2 0 0 2 2 2 1 Glycerol-3-phosphate responsive antiterminator ThiG PF05690.14 ACS98844.1 - 0.013 14.8 0.3 0.74 9.1 0.1 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG PcrB PF01884.17 ACS98844.1 - 0.021 14.3 0.1 0.043 13.3 0.1 1.5 1 0 0 1 1 1 0 PcrB family Flu_PB2 PF00604.17 ACS98844.1 - 0.16 9.9 0.0 0.22 9.4 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB2 PRA-CH PF01502.18 ACS98845.1 - 6.9e-34 115.5 0.5 1.1e-33 114.9 0.5 1.3 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 ACS98845.1 - 1.5e-17 63.8 0.1 2.2e-17 63.3 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 ACS98845.1 - 2e-05 24.7 0.2 3.8e-05 23.8 0.2 1.4 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain PHP PF02811.19 ACS98846.1 - 6.9e-13 49.2 0.6 3.9e-12 46.8 0.6 2.0 1 1 0 1 1 1 1 PHP domain PHP_C PF13263.6 ACS98846.1 - 9.3e-06 25.3 0.0 2e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 PHP-associated Radical_SAM PF04055.21 ACS98846.1 - 0.023 15.1 0.3 0.2 12.0 0.2 2.1 1 1 0 2 2 2 0 Radical SAM superfamily Pribosyltran_N PF13793.6 ACS98847.1 - 1.7e-47 160.1 0.1 4.8e-46 155.5 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 ACS98847.1 - 2.8e-24 86.2 0.7 1.3e-23 84.0 0.6 2.0 1 1 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 ACS98847.1 - 3.1e-16 59.3 0.2 1.3e-15 57.2 0.1 2.0 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ACS98847.1 - 0.00016 21.2 0.1 0.00026 20.5 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 ACS98847.1 - 0.013 15.0 0.1 0.025 14.1 0.1 1.5 1 0 0 1 1 1 0 Phosphoribosyl transferase TPR_19 PF14559.6 ACS98848.1 - 1.6e-22 79.8 6.5 1.2e-09 38.5 0.3 5.0 3 2 1 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ACS98848.1 - 3.4e-21 73.6 22.1 8.9e-06 25.4 0.5 8.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 ACS98848.1 - 3.1e-15 55.2 23.7 4.5e-07 29.4 0.5 7.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 ACS98848.1 - 3.8e-14 52.2 7.5 0.013 16.2 0.2 7.8 2 2 5 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 ACS98848.1 - 8.4e-13 47.8 1.6 0.0071 16.0 0.2 4.7 3 1 1 4 4 4 4 TPR repeat TPR_17 PF13431.6 ACS98848.1 - 1.5e-12 46.9 6.0 0.012 16.0 0.0 6.5 7 0 0 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ACS98848.1 - 1e-11 44.9 6.1 0.012 15.8 0.2 3.6 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ACS98848.1 - 6.3e-10 39.5 7.0 0.00029 21.4 0.1 4.8 4 1 1 5 5 4 4 Tetratricopeptide repeat HEAT_2 PF13646.6 ACS98848.1 - 4.6e-09 36.6 0.0 0.00039 20.8 0.1 4.1 3 1 0 3 3 3 1 HEAT repeats Fis1_TPR_C PF14853.6 ACS98848.1 - 2.2e-08 34.0 17.8 0.0025 17.8 0.1 6.4 7 0 0 7 7 6 3 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 ACS98848.1 - 5.3e-08 32.4 0.3 0.00023 20.5 0.1 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ACS98848.1 - 9.4e-08 31.7 18.6 0.00024 21.1 0.3 7.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 ACS98848.1 - 1.3e-07 31.7 2.2 0.16 12.2 0.1 4.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ACS98848.1 - 1.4e-07 31.0 19.0 0.38 10.9 0.1 8.3 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_6 PF13174.6 ACS98848.1 - 3.7e-06 27.2 11.6 0.67 10.7 0.1 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 ACS98848.1 - 6.6e-06 26.4 0.2 0.47 10.8 0.0 4.8 1 1 2 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ACS98848.1 - 2.6e-05 24.4 20.7 0.011 16.0 1.0 6.8 4 3 1 5 5 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ACS98848.1 - 3.2e-05 23.7 22.6 0.051 13.5 1.2 7.2 7 1 1 8 8 7 1 Tetratricopeptide repeat NARP1 PF12569.8 ACS98848.1 - 0.00012 21.2 1.0 0.0078 15.2 0.0 2.9 3 0 0 3 3 3 1 NMDA receptor-regulated protein 1 Coatomer_E PF04733.14 ACS98848.1 - 0.00033 20.2 2.8 0.0052 16.2 0.0 3.5 4 1 1 5 5 4 1 Coatomer epsilon subunit HrpB1_HrpK PF09613.10 ACS98848.1 - 0.00051 19.7 0.4 0.19 11.4 0.1 3.7 3 1 0 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_4 PF07721.14 ACS98848.1 - 0.0046 17.4 1.6 1.2e+02 3.7 0.0 5.5 6 0 0 6 6 4 0 Tetratricopeptide repeat Trp_repressor PF01371.19 ACS98848.1 - 0.0079 16.3 0.0 0.033 14.3 0.0 2.0 1 0 0 1 1 1 1 Trp repressor protein Alkyl_sulf_dimr PF14863.6 ACS98848.1 - 0.058 13.9 0.2 1.4 9.3 0.1 2.7 3 0 0 3 3 2 0 Alkyl sulfatase dimerisation TPR_5 PF12688.7 ACS98848.1 - 0.06 13.6 0.0 13 6.1 0.0 3.7 4 0 0 4 4 4 0 Tetratrico peptide repeat HTH_23 PF13384.6 ACS98848.1 - 0.092 12.6 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain TPR_MalT PF17874.1 ACS98848.1 - 0.15 11.4 4.0 0.34 10.2 0.6 2.8 2 1 0 3 3 3 0 MalT-like TPR region BTAD PF03704.17 ACS98848.1 - 1.2 9.5 5.7 8.5 6.8 2.6 2.8 2 0 0 2 2 2 0 Bacterial transcriptional activator domain MIT PF04212.18 ACS98848.1 - 6.8 6.8 6.7 4 7.6 0.1 4.0 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain Pyr_redox_2 PF07992.14 ACS98849.1 - 1.2e-51 175.8 0.1 1.3e-51 175.6 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACS98849.1 - 1.6e-26 93.3 0.2 7.1e-20 71.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACS98849.1 - 2.1e-19 69.8 0.6 5.3e-16 58.9 0.1 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ACS98849.1 - 3.2e-07 29.8 3.0 0.00054 19.2 0.0 3.2 2 1 2 4 4 4 2 FAD binding domain NAD_binding_8 PF13450.6 ACS98849.1 - 3.2e-07 30.5 0.0 3e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 ACS98849.1 - 1.7e-06 27.4 0.0 0.086 12.0 0.0 3.2 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 ACS98849.1 - 1.1e-05 24.3 0.0 0.0029 16.4 0.0 3.4 4 0 0 4 4 4 1 HI0933-like protein Thi4 PF01946.17 ACS98849.1 - 6.6e-05 22.3 0.0 0.00069 18.9 0.0 2.1 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.7 ACS98849.1 - 7.9e-05 22.2 0.3 0.0064 15.9 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.24 ACS98849.1 - 9.8e-05 22.1 3.1 0.14 11.8 0.1 3.1 2 1 1 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 ACS98849.1 - 0.00022 20.4 1.4 0.027 13.6 0.0 3.5 3 1 2 5 5 5 1 Glucose inhibited division protein A NAD_binding_7 PF13241.6 ACS98849.1 - 0.00028 21.3 0.0 0.0049 17.3 0.0 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 ACS98849.1 - 0.00049 19.4 0.1 0.02 14.1 0.0 2.4 2 1 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 ACS98849.1 - 0.0082 15.0 0.1 0.67 8.7 0.1 2.4 3 0 0 3 3 3 1 Tryptophan halogenase Shikimate_DH PF01488.20 ACS98849.1 - 0.042 13.9 0.1 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 ACS98849.1 - 0.076 13.0 0.2 2.2 8.3 0.1 2.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 ACS98849.1 - 0.14 11.5 0.1 4 6.7 0.0 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 ACS98849.1 - 0.15 11.0 0.0 0.61 9.1 0.1 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein MCRA PF06100.11 ACS98849.1 - 0.17 10.6 0.0 0.63 8.8 0.0 1.9 2 0 0 2 2 2 0 MCRA family ROK PF00480.20 ACS98850.1 - 2e-71 240.9 9.5 2.3e-71 240.7 9.5 1.0 1 0 0 1 1 1 1 ROK family BcrAD_BadFG PF01869.20 ACS98850.1 - 2.1e-07 30.7 5.6 1.1e-06 28.4 5.6 2.0 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family FGGY_N PF00370.21 ACS98850.1 - 0.00025 20.7 0.0 0.00045 19.9 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain ATP_bind_2 PF03668.15 ACS98851.1 - 1.3e-112 375.7 0.0 1.6e-112 375.4 0.0 1.0 1 0 0 1 1 1 1 P-loop ATPase protein family AAA_18 PF13238.6 ACS98851.1 - 0.0005 20.6 0.3 0.26 11.8 0.0 2.6 1 1 1 2 2 2 2 AAA domain AAA_33 PF13671.6 ACS98851.1 - 0.039 14.1 0.1 0.48 10.6 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ACS98851.1 - 0.11 12.9 0.2 0.21 12.0 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 ACS98851.1 - 0.18 11.5 0.4 0.33 10.6 0.4 1.3 1 0 0 1 1 1 0 AAA domain UPF0052 PF01933.18 ACS98852.1 - 1e-107 359.8 0.5 1.2e-107 359.6 0.5 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 LAGLIDADG_WhiA PF14527.6 ACS98853.1 - 1.1e-40 137.6 5.1 3.2e-37 126.5 0.2 2.6 3 0 0 3 3 3 2 WhiA LAGLIDADG-like domain WhiA_N PF10298.9 ACS98853.1 - 1.4e-36 124.4 3.0 3.3e-36 123.2 1.8 2.2 2 1 1 3 3 3 1 WhiA N-terminal LAGLIDADG-like domain HTH_WhiA PF02650.14 ACS98853.1 - 5.9e-36 122.7 1.0 1.7e-35 121.2 1.0 1.8 1 0 0 1 1 1 1 WhiA C-terminal HTH domain LAGLIDADG_3 PF14528.6 ACS98853.1 - 1.1e-10 41.7 0.7 6.8e-05 23.1 0.0 2.7 2 1 0 2 2 2 2 LAGLIDADG-like domain LAGLIDADG_2 PF03161.13 ACS98853.1 - 0.0023 18.0 0.1 0.057 13.5 0.0 2.2 2 0 0 2 2 2 1 LAGLIDADG DNA endonuclease family Hom_end PF05204.14 ACS98853.1 - 0.025 14.7 0.0 0.34 11.1 0.0 2.3 2 0 0 2 2 2 0 Homing endonuclease DUF1829 PF08862.10 ACS98853.1 - 0.032 14.7 0.1 0.072 13.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF1829 DUF3486 PF11985.8 ACS98853.1 - 0.051 14.0 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) Sigma70_r4 PF04545.16 ACS98853.1 - 0.069 12.7 0.0 0.21 11.2 0.0 1.9 1 0 0 1 1 1 0 Sigma-70, region 4 PTS-HPr PF00381.19 ACS98854.1 - 2.2e-32 111.1 0.5 2.6e-32 110.9 0.5 1.0 1 0 0 1 1 1 1 PTS HPr component phosphorylation site CLP_protease PF00574.23 ACS98855.1 - 1e-87 292.7 0.2 1.2e-87 292.5 0.2 1.0 1 0 0 1 1 1 1 Clp protease Sugar-bind PF04198.13 ACS98856.1 - 8.8e-66 221.6 2.0 1.2e-65 221.2 2.0 1.1 1 0 0 1 1 1 1 Putative sugar-binding domain DeoRC PF00455.22 ACS98856.1 - 0.0061 16.5 0.0 0.016 15.2 0.0 1.7 2 0 0 2 2 2 1 DeoR C terminal sensor domain DUF3683 PF12447.8 ACS98856.1 - 0.031 14.4 0.2 0.13 12.4 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3683) NDK PF00334.19 ACS98856.1 - 0.14 12.2 0.1 0.77 9.8 0.1 2.0 2 0 0 2 2 2 0 Nucleoside diphosphate kinase Gp_dh_C PF02800.20 ACS98857.1 - 1.4e-73 245.7 0.3 2.4e-73 244.9 0.3 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ACS98857.1 - 1e-40 138.2 1.9 2.8e-40 136.8 0.3 2.3 3 0 0 3 3 3 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 ACS98857.1 - 0.00011 22.3 0.3 0.00075 19.6 0.2 2.4 1 1 1 2 2 2 1 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 ACS98857.1 - 0.066 12.6 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PGK PF00162.19 ACS98858.1 - 3e-159 530.0 0.9 3.4e-159 529.8 0.9 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase IF2_N PF04760.15 ACS98858.1 - 0.0072 16.1 0.0 0.032 14.1 0.0 2.1 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region TIM PF00121.18 ACS98859.1 - 1e-93 313.2 0.6 1.1e-93 313.1 0.6 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase iPGM_N PF06415.13 ACS98860.1 - 3.4e-85 284.9 0.0 6.5e-85 284.0 0.0 1.5 2 0 0 2 2 2 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 ACS98860.1 - 4.2e-78 262.1 0.0 4.9e-78 261.9 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 ACS98860.1 - 6.4e-05 22.7 0.0 0.00013 21.6 0.0 1.6 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ACS98860.1 - 0.019 14.4 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 Sulfatase PglZ PF08665.12 ACS98860.1 - 0.067 13.3 0.1 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 PglZ domain Enolase_C PF00113.22 ACS98861.1 - 3.6e-137 456.5 0.3 4.6e-137 456.1 0.3 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 ACS98861.1 - 1.4e-60 203.2 0.5 2.4e-60 202.4 0.5 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 ACS98861.1 - 7.1e-05 22.5 0.0 0.00012 21.8 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 ACS98861.1 - 0.00031 20.0 0.8 0.00054 19.2 0.1 1.7 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus GhoS PF11080.8 ACS98861.1 - 0.061 13.3 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 Endoribonuclease GhoS SecG PF03840.14 ACS98862.1 - 7.2e-21 74.1 6.3 8.1e-21 73.9 6.3 1.0 1 0 0 1 1 1 1 Preprotein translocase SecG subunit RNB PF00773.19 ACS98863.1 - 3.9e-112 374.8 0.6 5.4e-112 374.3 0.2 1.4 2 0 0 2 2 2 1 RNB domain CSD2 PF17876.1 ACS98863.1 - 8.8e-39 131.5 3.7 7.4e-31 106.1 0.4 3.2 3 0 0 3 3 3 2 Cold shock domain OB_RNB PF08206.11 ACS98863.1 - 5.5e-31 106.0 2.1 4.5e-18 64.7 0.1 3.1 2 0 0 2 2 2 2 Ribonuclease B OB domain S1 PF00575.23 ACS98863.1 - 2.6e-13 50.1 0.3 2.6e-13 50.1 0.3 2.7 2 0 0 2 2 2 1 S1 RNA binding domain OB_Dis3 PF17849.1 ACS98863.1 - 1.4e-05 25.0 0.0 0.00019 21.4 0.0 2.3 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) CSD PF00313.22 ACS98863.1 - 0.006 16.4 1.3 0.26 11.2 0.4 2.8 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain CSD PF00313.22 ACS98864.1 - 4.4e-30 103.3 4.0 4.7e-30 103.2 4.0 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 ACS98864.1 - 0.0051 16.5 1.2 0.0056 16.3 1.2 1.5 1 1 0 1 1 1 1 Ribonuclease B OB domain SmpB PF01668.18 ACS98865.1 - 1.3e-60 203.5 0.5 1.5e-60 203.3 0.5 1.0 1 0 0 1 1 1 1 SmpB protein Drf_GBD PF06371.13 ACS98866.1 - 0.13 11.9 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain DUF792 PF05632.11 ACS98867.1 - 0.072 13.0 0.1 0.089 12.7 0.1 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF792) His_kinase PF06580.13 ACS98869.1 - 3.2e-23 81.8 0.1 1.1e-22 80.1 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase HATPase_c PF02518.26 ACS98869.1 - 3.1e-09 37.3 0.0 5.9e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACS98869.1 - 5.1e-08 33.2 0.0 1e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 HAMP domain dCache_1 PF02743.18 ACS98869.1 - 7.5e-05 22.6 4.0 0.00016 21.6 4.0 1.5 1 0 0 1 1 1 1 Cache domain HATPase_c_2 PF13581.6 ACS98869.1 - 0.00072 19.5 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HTH_18 PF12833.7 ACS98870.1 - 7e-25 87.1 1.3 2.9e-24 85.2 0.2 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain Response_reg PF00072.24 ACS98870.1 - 9.1e-25 87.0 0.1 3.1e-24 85.3 0.1 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HTH_AraC PF00165.23 ACS98870.1 - 1.2e-18 66.7 0.1 8e-11 41.8 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACS98870.1 - 1.9e-05 24.9 0.0 0.0001 22.5 0.0 2.2 2 0 0 2 2 2 1 GGDEF-like domain SIP1 PF04938.12 ACS98870.1 - 0.024 14.4 0.1 0.096 12.4 0.1 1.9 2 0 0 2 2 2 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) SBP_bac_1 PF01547.25 ACS98871.1 - 5e-42 145.0 15.1 5e-42 145.0 15.1 1.5 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACS98871.1 - 4e-34 118.7 15.9 4e-34 118.7 15.9 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACS98871.1 - 9.3e-06 25.2 0.4 0.0016 17.9 0.0 2.6 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACS98871.1 - 0.0001 22.1 0.4 0.059 13.1 0.0 3.0 4 0 0 4 4 4 2 Bacterial extracellular solute-binding protein DUF4404 PF14357.6 ACS98871.1 - 0.12 13.1 0.1 0.74 10.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF3558 PF12079.8 ACS98871.1 - 0.89 9.5 4.1 1.5 8.8 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) BPD_transp_1 PF00528.22 ACS98872.1 - 8.6e-15 55.0 19.0 8.6e-15 55.0 19.0 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS98873.1 - 9.3e-19 67.9 13.7 9.3e-19 67.9 13.7 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component F5_F8_type_C PF00754.25 ACS98874.1 - 4.2e-13 49.5 3.9 2.4e-12 47.1 3.9 2.4 1 0 0 1 1 1 1 F5/8 type C domain Melibiase_C PF17801.1 ACS98874.1 - 5.4e-07 29.6 0.0 2.3e-06 27.6 0.0 2.1 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase_2 PF16499.5 ACS98874.1 - 0.028 13.6 0.4 0.14 11.3 0.2 2.2 2 1 0 2 2 2 0 Alpha galactosidase A BNR PF02012.20 ACS98874.1 - 0.21 11.7 2.1 3.4 8.0 0.3 3.4 2 0 0 2 2 2 0 BNR/Asp-box repeat HisKA_7TM PF16927.5 ACS98875.1 - 6.9e-55 186.5 22.0 9.4e-55 186.0 22.0 1.1 1 0 0 1 1 1 1 N-terminal 7TM region of histidine kinase HATPase_c PF02518.26 ACS98875.1 - 8.1e-17 61.7 0.0 1.7e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACS98875.1 - 5e-06 26.5 0.5 1.7e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 ACS98875.1 - 0.0035 17.3 0.0 0.012 15.6 0.0 2.0 1 0 0 1 1 1 1 PAS domain DUF4293 PF14126.6 ACS98875.1 - 0.0052 17.1 0.1 0.01 16.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4293) PAS_4 PF08448.10 ACS98875.1 - 0.012 15.8 0.0 0.039 14.2 0.0 1.9 1 1 0 1 1 1 0 PAS fold HATPase_c_2 PF13581.6 ACS98875.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain DUF202 PF02656.15 ACS98875.1 - 0.65 10.5 4.3 1.1 9.7 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF202) DUF2070 PF09843.9 ACS98875.1 - 1.3 7.2 7.7 2 6.6 7.7 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Response_reg PF00072.24 ACS98876.1 - 4.8e-21 75.0 0.0 8.5e-21 74.2 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain BTAD PF03704.17 ACS98876.1 - 1.9e-10 41.4 0.1 3.4e-10 40.5 0.1 1.3 1 0 0 1 1 1 1 Bacterial transcriptional activator domain Trans_reg_C PF00486.28 ACS98876.1 - 5.1e-06 26.5 0.0 1.3e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal TPR_19 PF14559.6 ACS98876.1 - 0.1 13.1 1.7 0.12 12.9 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat SLH PF00395.20 ACS98877.1 - 1.3e-32 111.6 0.1 6.1e-12 45.3 0.1 4.1 3 0 0 3 3 3 3 S-layer homology domain Big_5 PF13205.6 ACS98877.1 - 9.5e-14 52.0 66.6 0.15 12.7 0.5 16.9 13 3 5 19 19 19 8 Bacterial Ig-like domain DUF3244 PF11589.8 ACS98877.1 - 0.00011 22.3 5.3 1.8 8.7 0.0 9.2 13 0 0 13 13 13 1 Domain of unknown function (DUF3244) fn3 PF00041.21 ACS98877.1 - 0.00068 19.9 0.9 29 5.1 0.0 6.6 6 0 0 6 6 6 0 Fibronectin type III domain DUF2012 PF09430.10 ACS98877.1 - 0.0031 17.6 0.4 1.8 8.7 0.0 5.0 5 0 0 5 5 5 1 Protein of unknown function (DUF2012) Pur_ac_phosph_N PF16656.5 ACS98877.1 - 0.044 14.3 7.1 2.8 8.6 0.7 5.4 4 1 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain GPI-anchored PF10342.9 ACS98877.1 - 0.062 14.1 30.8 2.1 9.2 0.1 11.7 14 0 0 14 14 14 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SWM_repeat PF13753.6 ACS98877.1 - 0.13 12.5 10.8 0.037 14.2 0.4 5.1 3 1 1 4 4 4 0 Putative flagellar system-associated repeat His_kinase PF06580.13 ACS98878.1 - 7.3e-21 74.3 3.4 7.3e-21 74.3 3.4 2.0 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACS98878.1 - 4.7e-11 43.2 0.0 1e-10 42.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACS98878.1 - 0.04 14.3 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 HAMP domain HATPase_c_2 PF13581.6 ACS98878.1 - 0.076 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACS98878.1 - 0.09 12.6 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HR_lesion PF05514.11 ACS98878.1 - 0.1 12.8 0.3 0.25 11.5 0.3 1.6 1 0 0 1 1 1 0 HR-like lesion-inducing TLE_N PF03920.15 ACS98878.1 - 0.16 12.0 5.3 0.058 13.5 2.0 2.0 2 0 0 2 2 2 0 Groucho/TLE N-terminal Q-rich domain FGGY_N PF00370.21 ACS98878.1 - 0.22 11.1 1.7 0.3 10.6 0.4 1.8 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain Response_reg PF00072.24 ACS98879.1 - 1.2e-21 77.0 0.2 2.2e-21 76.1 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS98879.1 - 4.1e-20 71.8 2.9 9.5e-20 70.7 0.4 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS98879.1 - 4.9e-14 52.0 1.5 4.6e-08 33.0 0.1 3.3 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family SBP_bac_1 PF01547.25 ACS98880.1 - 1.1e-13 51.8 16.7 2.2e-13 50.9 16.7 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACS98881.1 - 1.7e-12 47.4 12.9 1.7e-12 47.4 12.9 2.5 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS98882.1 - 1.5e-10 41.2 12.7 5.9e-10 39.2 12.6 2.1 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component RHH_3 PF12651.7 ACS98882.1 - 0.0053 16.7 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 Ribbon-helix-helix domain SAUGI PF06106.11 ACS98882.1 - 0.097 13.2 0.1 0.21 12.1 0.0 1.6 1 1 0 1 1 1 0 S. aureus uracil DNA glycosylase inhibitor HTH_18 PF12833.7 ACS98885.1 - 5.1e-20 71.5 0.1 1.2e-19 70.3 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS98885.1 - 2.6e-19 68.8 0.1 2.5e-08 33.8 0.1 2.9 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Peripla_BP_2 PF01497.18 ACS98885.1 - 5.1e-13 49.1 0.0 8.6e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein HTH_3 PF01381.22 ACS98885.1 - 0.0071 16.4 0.0 0.017 15.2 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix Oxidored_nitro PF00148.19 ACS98885.1 - 0.0072 15.1 0.0 1.1 7.9 0.0 2.3 2 1 1 3 3 3 2 Nitrogenase component 1 type Oxidoreductase FecCD PF01032.18 ACS98886.1 - 8e-81 271.4 30.5 9e-81 271.3 30.5 1.0 1 0 0 1 1 1 1 FecCD transport family Adeno_E3 PF06040.11 ACS98886.1 - 0.045 13.9 0.3 0.079 13.1 0.3 1.4 1 0 0 1 1 1 0 Adenovirus E3 protein FecCD PF01032.18 ACS98887.1 - 1.6e-85 286.9 34.9 2e-85 286.6 34.9 1.0 1 0 0 1 1 1 1 FecCD transport family Peripla_BP_2 PF01497.18 ACS98888.1 - 1.4e-36 126.3 0.5 1.7e-36 126.0 0.5 1.1 1 0 0 1 1 1 1 Periplasmic binding protein LPAM_2 PF13627.6 ACS98888.1 - 0.25 11.3 3.5 0.41 10.6 3.5 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site MFS_1 PF07690.16 ACS98889.1 - 2.8e-38 131.8 90.8 1.1e-29 103.5 48.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ACS98889.1 - 1.1e-09 38.1 44.2 1.4e-09 37.8 44.2 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB TetR_C_11 PF16859.5 ACS98890.1 - 1.3e-31 109.3 0.1 2e-31 108.6 0.1 1.3 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 ACS98890.1 - 3.6e-11 42.7 0.0 6.9e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_7 PF02796.15 ACS98890.1 - 0.00015 21.7 0.3 0.0022 18.1 0.1 2.6 2 1 0 2 2 2 1 Helix-turn-helix domain of resolvase TetR_C_7 PF14246.6 ACS98890.1 - 0.00017 21.6 0.0 0.00028 20.9 0.0 1.2 1 0 0 1 1 1 1 AefR-like transcriptional repressor, C-terminal domain HTH_Tnp_1_2 PF13022.6 ACS98890.1 - 0.00055 20.1 0.0 0.00092 19.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase HTH_11 PF08279.12 ACS98890.1 - 0.0072 16.3 0.3 0.02 14.8 0.0 1.9 2 0 0 2 2 2 1 HTH domain HTH_17 PF12728.7 ACS98890.1 - 0.015 15.5 0.0 0.046 13.9 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4 PF04545.16 ACS98890.1 - 0.017 14.7 0.0 0.52 9.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_22 PF13309.6 ACS98890.1 - 0.051 13.6 0.1 0.16 12.0 0.1 1.8 2 0 0 2 2 2 0 HTH domain HTH_23 PF13384.6 ACS98890.1 - 0.056 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain TrmB PF01978.19 ACS98890.1 - 0.075 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB CN_hydrolase PF00795.22 ACS98891.1 - 4.5e-58 196.6 0.0 5.1e-58 196.5 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase dCache_1 PF02743.18 ACS98891.1 - 0.00073 19.4 0.0 0.24 11.2 0.0 2.3 2 0 0 2 2 2 2 Cache domain PAD_porph PF04371.15 ACS98892.1 - 3.2e-120 401.2 0.0 3.6e-120 401.1 0.0 1.0 1 0 0 1 1 1 1 Porphyromonas-type peptidyl-arginine deiminase TetR_C_8 PF14278.6 ACS98893.1 - 8.2e-14 51.6 0.4 8.2e-14 51.6 0.4 2.3 2 1 1 3 3 3 1 Transcriptional regulator C-terminal region TetR_N PF00440.23 ACS98893.1 - 0.00018 21.3 0.0 0.00032 20.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family adh_short_C2 PF13561.6 ACS98894.1 - 2.4e-57 194.2 7.7 2.8e-57 194.0 7.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACS98894.1 - 6.8e-49 166.0 9.4 8.3e-49 165.7 9.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACS98894.1 - 3.1e-11 43.5 3.5 4.7e-11 42.9 3.5 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ACS98894.1 - 0.00035 20.5 2.4 0.00052 19.9 2.4 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF3783 PF12646.7 ACS98894.1 - 0.036 14.0 0.0 0.074 13.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3783) HAD_2 PF13419.6 ACS98895.1 - 3e-21 76.3 0.0 1.3e-20 74.2 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACS98895.1 - 1.6e-15 58.0 0.0 4e-15 56.7 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACS98895.1 - 2.1e-08 34.1 0.0 4.1e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ACS98895.1 - 2.6e-05 24.7 0.0 3.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 ACS98895.1 - 0.078 12.6 0.0 8.7 5.9 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase Hydrolase_3 PF08282.12 ACS98895.1 - 0.22 11.3 0.0 4.6 6.9 0.0 2.4 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Aminotran_3 PF00202.21 ACS98896.1 - 3.6e-84 282.8 0.0 4.2e-84 282.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ACS98896.1 - 0.021 14.0 0.0 0.19 10.9 0.0 2.3 3 0 0 3 3 3 0 Aminotransferase class I and II DeoRC PF00455.22 ACS98897.1 - 3.4e-41 140.9 0.0 4.4e-41 140.5 0.0 1.1 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 ACS98897.1 - 7.3e-18 64.1 0.3 1.3e-17 63.3 0.3 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACS98897.1 - 2.2e-09 37.1 0.1 4.4e-09 36.1 0.1 1.5 1 0 0 1 1 1 1 HTH domain FeoC PF09012.10 ACS98897.1 - 0.00029 20.9 0.0 0.00064 19.7 0.0 1.5 1 0 0 1 1 1 1 FeoC like transcriptional regulator GntR PF00392.21 ACS98897.1 - 0.0013 18.4 0.1 0.0027 17.3 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_5 PF01022.20 ACS98897.1 - 0.0033 17.3 0.0 0.0077 16.1 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DDRGK PF09756.9 ACS98897.1 - 0.0083 15.7 0.1 0.019 14.6 0.1 1.5 1 0 0 1 1 1 1 DDRGK domain MarR PF01047.22 ACS98897.1 - 0.015 15.2 0.1 0.037 14.0 0.1 1.7 1 0 0 1 1 1 0 MarR family FaeA PF04703.12 ACS98897.1 - 0.019 15.3 0.0 0.034 14.5 0.0 1.4 1 0 0 1 1 1 0 FaeA-like protein Put_DNA-bind_N PF06971.13 ACS98897.1 - 0.023 14.7 0.1 0.073 13.1 0.0 1.9 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus MarR_2 PF12802.7 ACS98897.1 - 0.064 13.2 0.0 0.31 11.0 0.0 2.1 2 0 0 2 2 2 0 MarR family HTH_24 PF13412.6 ACS98897.1 - 0.11 12.1 0.3 0.23 11.1 0.3 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 ACS98897.1 - 0.13 12.4 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_7 PF02796.15 ACS98897.1 - 0.26 11.4 1.2 2.3 8.4 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase Glyoxalase_6 PF18029.1 ACS98898.1 - 1.4e-05 25.8 0.0 2.4e-05 25.1 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 ACS98898.1 - 0.00012 22.3 0.0 0.00014 22.1 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ACS98898.1 - 0.008 16.4 0.0 0.033 14.4 0.0 1.9 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PMSR PF01625.21 ACS98899.1 - 3.6e-38 131.1 0.0 4.6e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Ribosomal_S21 PF01165.20 ACS98899.1 - 0.054 13.2 0.4 0.093 12.5 0.4 1.3 1 0 0 1 1 1 0 Ribosomal protein S21 CBM_6 PF03422.15 ACS98900.1 - 3.9e-82 272.7 24.1 5.3e-32 110.8 2.4 4.1 4 0 0 4 4 4 3 Carbohydrate binding module (family 6) Glyco_hydro_76 PF03663.14 ACS98900.1 - 1.9e-45 156.0 26.4 3.4e-45 155.2 26.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DUF5010_C PF18099.1 ACS98900.1 - 1e-14 54.6 0.4 3.4e-05 23.9 0.0 4.0 3 0 0 3 3 3 3 DUF5010 C-terminal domain Glyco_hydro_127 PF07944.12 ACS98900.1 - 1.4e-05 23.8 2.7 3e-05 22.7 2.2 1.6 1 1 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 C5-epim_C PF06662.13 ACS98900.1 - 0.00014 21.4 2.3 0.54 9.7 0.1 3.7 2 1 1 3 3 3 2 D-glucuronyl C5-epimerase C-terminus fn3 PF00041.21 ACS98900.1 - 0.0026 18.1 0.0 0.0071 16.7 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain DUF4959 PF16323.5 ACS98900.1 - 0.0064 16.8 0.1 0.014 15.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4959) Glyco_hydro_10 PF00331.20 ACS98901.1 - 5.3e-103 344.5 5.3 5.3e-103 344.5 5.3 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 10 CBM9_1 PF06452.11 ACS98901.1 - 1.4e-64 217.4 8.5 1.4e-64 217.4 8.5 2.3 2 0 0 2 2 2 1 Carbohydrate family 9 binding domain-like SLH PF00395.20 ACS98901.1 - 6.2e-34 115.8 4.6 1.2e-10 41.2 0.2 3.8 3 0 0 3 3 3 3 S-layer homology domain CBM_4_9 PF02018.17 ACS98901.1 - 9.3e-31 106.9 35.0 1.2e-17 64.5 4.0 4.6 4 0 0 4 4 4 4 Carbohydrate binding domain Receptor_IA-2 PF11548.8 ACS98901.1 - 0.023 14.7 0.0 0.064 13.2 0.0 1.7 1 0 0 1 1 1 0 Protein-tyrosine phosphatase receptor IA-2 SspK PF08176.12 ACS98901.1 - 0.19 12.0 0.1 22 5.4 0.0 3.1 3 0 0 3 3 3 0 Small acid-soluble spore protein K family Lyase_8_C PF02884.17 ACS98901.1 - 0.9 10.1 6.9 16 6.1 0.1 4.7 4 0 0 4 4 4 0 Polysaccharide lyase family 8, C-terminal beta-sandwich domain MFS_1 PF07690.16 ACS98902.1 - 1.1e-34 119.9 56.3 1.6e-26 93.1 27.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ACS98902.1 - 5.8e-11 41.9 28.6 1e-08 34.5 5.8 3.0 1 1 2 3 3 3 2 MFS_1 like family OATP PF03137.20 ACS98902.1 - 0.00012 20.5 16.7 0.00077 17.9 0.3 3.7 1 1 3 5 5 5 3 Organic Anion Transporter Polypeptide (OATP) family TcdA_TcdB_pore PF12920.7 ACS98902.1 - 1 7.5 2.6 1.9 6.6 2.6 1.3 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain DUF3767 PF12597.8 ACS98902.1 - 1.1 9.1 2.9 1.4 8.8 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3767) DUF423 PF04241.15 ACS98903.1 - 1.3e-30 105.4 0.1 2.5e-30 104.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Glyoxalase PF00903.25 ACS98904.1 - 1.4e-09 38.2 0.0 1.6e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ACS98904.1 - 2.5e-06 27.7 0.1 6.6e-06 26.4 0.1 1.7 1 1 1 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ACS98904.1 - 6.6e-06 26.9 0.0 8.9e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 ACS98904.1 - 0.00038 20.6 0.1 0.00061 20.0 0.1 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_5 PF14696.6 ACS98904.1 - 0.074 13.2 0.1 0.17 12.0 0.0 1.6 2 0 0 2 2 2 0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Pfk_N PF18468.1 ACS98904.1 - 0.085 13.3 0.0 0.14 12.6 0.0 1.5 1 1 0 1 1 1 0 Phosphofructokinase N-terminal domain yeast TPR_8 PF13181.6 ACS98904.1 - 0.086 13.1 0.9 0.96 9.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat HTH_AsnC-type PF13404.6 ACS98905.1 - 6.7e-14 51.4 0.1 1.2e-13 50.6 0.1 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 ACS98905.1 - 7.6e-14 51.0 0.2 1.7e-13 49.9 0.1 1.7 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 ACS98905.1 - 8.6e-10 38.5 0.0 1.7e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_5 PF01022.20 ACS98905.1 - 2.3e-05 24.2 0.7 5.5e-05 23.0 0.1 1.9 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACS98905.1 - 0.00011 22.2 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 ACS98905.1 - 0.0014 18.5 0.1 0.0028 17.5 0.1 1.6 1 1 0 1 1 1 1 MarR family HTH_9 PF08221.11 ACS98905.1 - 0.0078 16.3 0.1 0.025 14.7 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 helix-turn-helix domain MarR_2 PF12802.7 ACS98905.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 MarR family HTH_11 PF08279.12 ACS98905.1 - 0.019 14.9 0.0 0.043 13.8 0.0 1.5 1 0 0 1 1 1 0 HTH domain Fe_dep_repress PF01325.19 ACS98905.1 - 0.022 14.9 0.3 0.044 14.0 0.3 1.5 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain TrmB PF01978.19 ACS98905.1 - 0.023 14.6 0.1 0.047 13.6 0.1 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.6 ACS98905.1 - 0.025 14.4 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Crp_2 PF13545.6 ACS98905.1 - 0.04 13.9 0.1 0.072 13.1 0.1 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain LexA_DNA_bind PF01726.16 ACS98905.1 - 0.054 13.3 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 LexA DNA binding domain DDRGK PF09756.9 ACS98905.1 - 0.084 12.5 0.1 0.28 10.7 0.0 1.7 2 0 0 2 2 2 0 DDRGK domain RPA_C PF08784.11 ACS98905.1 - 0.092 13.4 0.0 0.15 12.7 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal GntR PF00392.21 ACS98905.1 - 0.1 12.3 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family DUF2277 PF10041.9 ACS98906.1 - 3.6e-35 120.1 0.1 4.4e-35 119.9 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2277) HD_2 PF12917.7 ACS98907.1 - 1.2e-46 158.7 0.3 1.5e-46 158.5 0.3 1.1 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 ACS98907.1 - 5.6e-07 29.8 0.1 7.9e-07 29.3 0.1 1.2 1 0 0 1 1 1 1 HD domain HD_3 PF13023.6 ACS98907.1 - 7.9e-07 29.1 1.6 1.8e-06 28.0 0.8 1.8 1 1 1 2 2 2 1 HD domain Glyco_hydro_3 PF00933.21 ACS98908.1 - 5.1e-57 193.7 0.0 7.9e-57 193.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ACS98908.1 - 2.5e-42 145.1 1.1 6.6e-42 143.8 1.1 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ACS98908.1 - 1.7e-20 72.9 0.0 5.4e-20 71.3 0.0 2.0 1 0 0 1 1 1 1 Fibronectin type III-like domain CARDB PF07705.11 ACS98908.1 - 0.023 14.9 0.1 0.17 12.2 0.0 2.5 2 0 0 2 2 2 0 CARDB BclA_C PF18573.1 ACS98908.1 - 0.099 12.6 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 BclA C-terminal domain SEC-C PF02810.15 ACS98909.1 - 1e-10 41.3 12.1 1.8e-10 40.5 12.1 1.5 1 0 0 1 1 1 1 SEC-C motif Rho_N PF07498.12 ACS98909.1 - 0.012 15.5 0.6 0.012 15.5 0.6 2.0 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain DUF3235 PF11574.8 ACS98909.1 - 0.033 15.0 0.1 0.12 13.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3235) Mac PF12464.8 ACS98909.1 - 0.47 10.7 2.4 2.7 8.3 0.0 3.2 2 1 0 3 3 3 0 Maltose acetyltransferase MCPsignal PF00015.21 ACS98910.1 - 7e-35 120.4 16.5 7e-35 120.4 16.5 3.2 1 1 2 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 ACS98910.1 - 2.1e-08 34.4 4.9 4.9e-08 33.2 0.0 3.9 4 1 1 5 5 5 1 HAMP domain DUF948 PF06103.11 ACS98910.1 - 0.0032 17.7 18.8 0.97 9.7 1.5 5.5 2 2 3 5 5 5 2 Bacterial protein of unknown function (DUF948) sCache_3_3 PF17202.4 ACS98910.1 - 0.0058 17.0 0.0 0.023 15.1 0.0 2.1 1 0 0 1 1 1 1 Single cache domain 3 Cache_3-Cache_2 PF17201.4 ACS98910.1 - 0.008 15.5 0.1 0.008 15.5 0.1 3.3 2 1 0 2 2 2 1 Cache 3/Cache 2 fusion domain BLOC1_2 PF10046.9 ACS98910.1 - 0.025 14.8 15.8 3.3 8.1 1.1 5.1 2 2 3 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PAS_6 PF08348.11 ACS98910.1 - 0.062 13.2 0.2 1.1 9.2 0.0 3.0 2 1 1 3 3 3 0 YheO-like PAS domain DUF4618 PF15397.6 ACS98910.1 - 0.091 12.2 14.5 0.088 12.2 2.9 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4618) PAS_4 PF08448.10 ACS98910.1 - 0.11 12.8 0.1 1.2 9.4 0.0 2.6 2 0 0 2 2 2 0 PAS fold DUF1664 PF07889.12 ACS98910.1 - 0.11 12.5 21.3 0.39 10.8 1.3 4.4 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Serine_rich PF08824.10 ACS98910.1 - 2.8 7.9 10.0 5.4 7.0 2.1 2.9 2 2 0 2 2 2 0 Serine rich protein interaction domain Sec34 PF04136.15 ACS98910.1 - 4.5 7.1 12.7 2.4 8.0 1.4 4.0 3 1 0 3 3 3 0 Sec34-like family UPF0449 PF15136.6 ACS98910.1 - 6.3 7.3 7.9 16 6.0 0.8 3.8 2 2 1 3 3 3 0 Uncharacterised protein family UPF0449 Abhydrolase_6 PF12697.7 ACS98911.1 - 0.026 15.1 0.0 0.038 14.6 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family LysR_substrate PF03466.20 ACS98913.1 - 2.2e-39 135.0 0.0 2.7e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACS98913.1 - 3.3e-23 81.4 0.1 2e-22 78.9 0.0 2.2 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family Fe_dep_repress PF01325.19 ACS98913.1 - 0.0011 19.1 0.2 0.056 13.7 0.1 2.6 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain HTH_30 PF13556.6 ACS98913.1 - 0.0073 16.1 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_28 PF13518.6 ACS98913.1 - 0.042 14.0 0.0 0.079 13.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_8 PF02954.19 ACS98913.1 - 0.088 12.6 0.0 0.24 11.2 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family MarR_2 PF12802.7 ACS98913.1 - 0.12 12.3 0.1 0.72 9.8 0.0 2.3 2 0 0 2 2 2 0 MarR family HTH_24 PF13412.6 ACS98913.1 - 0.19 11.4 0.0 1.9 8.1 0.1 2.6 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding MFS_1 PF07690.16 ACS98914.1 - 7.2e-61 206.1 48.2 1.8e-39 135.7 24.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ACS98914.1 - 1.1e-11 44.2 33.2 8.4e-07 28.2 16.2 2.0 1 1 1 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 ACS98914.1 - 5e-11 42.1 42.2 5.9e-07 28.7 18.6 2.8 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.6 ACS98914.1 - 1.3e-09 37.2 43.3 4.2e-09 35.5 16.3 3.3 2 2 1 3 3 3 2 MFS/sugar transport protein MFS_3 PF05977.13 ACS98914.1 - 2e-05 23.2 13.6 8.9e-05 21.1 5.9 2.3 2 1 0 2 2 2 2 Transmembrane secretion effector PUCC PF03209.15 ACS98914.1 - 0.0013 17.8 21.8 0.033 13.2 1.7 3.2 2 1 1 3 3 3 2 PUCC protein LacY_symp PF01306.19 ACS98914.1 - 0.0021 16.9 26.2 0.057 12.2 10.9 2.2 2 0 0 2 2 2 2 LacY proton/sugar symporter VanZ PF04892.12 ACS98914.1 - 0.033 14.8 0.2 0.033 14.8 0.2 3.5 3 1 0 3 3 3 0 VanZ like family HxlR PF01638.17 ACS98915.1 - 5e-35 119.2 0.3 5.9e-35 119.0 0.3 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_20 PF12840.7 ACS98915.1 - 0.00045 20.2 0.0 0.00073 19.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_12 PF08461.10 ACS98915.1 - 0.017 15.0 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain BLACT_WH PF17778.1 ACS98915.1 - 2.4 8.2 5.4 1.6 8.8 0.7 2.6 2 1 1 3 3 3 0 Beta-lactamase associated winged helix domain Flavodoxin_2 PF02525.17 ACS98916.1 - 4.9e-45 153.7 0.0 6.1e-45 153.4 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ACS98916.1 - 4.8e-07 29.6 0.0 6.8e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase HxlR PF01638.17 ACS98917.1 - 2.3e-32 110.7 0.2 2.8e-32 110.4 0.2 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix MarR PF01047.22 ACS98917.1 - 0.00074 19.4 0.0 0.0017 18.2 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.6 ACS98917.1 - 0.012 15.8 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_20 PF12840.7 ACS98917.1 - 0.088 12.9 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain DoxX_2 PF13564.6 ACS98918.1 - 1.2e-26 92.7 9.8 1.4e-26 92.6 9.8 1.0 1 0 0 1 1 1 1 DoxX-like family DoxX PF07681.12 ACS98918.1 - 4.7e-06 27.1 8.1 4.7e-06 27.1 8.1 2.4 2 1 0 2 2 2 1 DoxX DUF1129 PF06570.11 ACS98918.1 - 0.0057 16.2 1.0 0.011 15.2 1.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1129) YrhC PF14143.6 ACS98918.1 - 0.16 12.1 4.0 0.27 11.3 0.2 2.4 1 1 0 2 2 2 0 YrhC-like protein CoatB PF10389.9 ACS98918.1 - 3.3 7.6 10.1 0.99 9.3 3.8 2.4 1 1 1 2 2 2 0 Bacteriophage coat protein B DUF302 PF03625.14 ACS98919.1 - 1.1e-07 31.6 0.0 1.9e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF302 HTH_1 PF00126.27 ACS98920.1 - 2e-20 72.5 0.9 4e-20 71.5 0.9 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 ACS98920.1 - 4.7e-16 58.8 0.2 7.1e-16 58.2 0.2 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_30 PF13556.6 ACS98920.1 - 0.0048 16.7 0.2 0.01 15.6 0.2 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain MarR_2 PF12802.7 ACS98920.1 - 0.013 15.4 0.1 0.057 13.3 0.1 2.1 1 0 0 1 1 1 0 MarR family HTH_50 PF18024.1 ACS98920.1 - 0.015 14.9 0.7 0.041 13.5 0.2 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.6 ACS98920.1 - 0.015 14.8 0.0 0.035 13.7 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR PF01047.22 ACS98920.1 - 0.048 13.6 0.1 0.22 11.5 0.1 2.0 2 0 0 2 2 2 0 MarR family HTH_AsnC-type PF13404.6 ACS98920.1 - 0.072 12.9 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Acetyltransf_1 PF00583.25 ACS98921.1 - 4.9e-12 46.1 0.0 6.8e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACS98921.1 - 2.4e-10 40.4 0.0 3e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACS98921.1 - 1.6e-09 38.1 0.0 2.6e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACS98921.1 - 7.3e-06 26.1 0.0 1.7e-05 24.9 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACS98921.1 - 2.1e-05 24.4 0.0 3.9e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 ACS98921.1 - 0.00037 20.2 0.0 0.00044 20.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_CG PF14542.6 ACS98921.1 - 0.0047 17.0 0.0 0.0096 16.0 0.0 1.6 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 ACS98921.1 - 0.019 14.5 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_13 PF13880.6 ACS98921.1 - 0.024 14.6 0.0 0.044 13.8 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase DUF2269 PF10027.9 ACS98922.1 - 0.014 15.5 17.3 0.087 12.9 17.3 1.9 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2269) MpPF26 PF07666.11 ACS98922.1 - 0.02 15.0 13.8 0.17 12.0 1.5 2.4 2 1 0 2 2 2 0 M penetrans paralogue family 26 DUF334 PF03904.13 ACS98922.1 - 2.1 7.8 9.6 0.088 12.3 3.4 1.7 1 1 0 2 2 2 0 Domain of unknown function (DUF334) Response_reg PF00072.24 ACS98923.1 - 3.6e-26 91.5 0.0 5.1e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACS98923.1 - 1.5e-25 89.1 0.0 3.2e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HATPase_c PF02518.26 ACS98924.1 - 8.2e-22 77.8 0.0 1.5e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACS98924.1 - 4.1e-15 55.9 0.4 4.1e-15 55.9 0.4 2.5 3 0 0 3 3 3 1 HAMP domain HisKA PF00512.25 ACS98924.1 - 3.7e-13 49.3 0.0 1.1e-12 47.8 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ACS98924.1 - 0.0027 17.5 0.0 0.0061 16.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ig_mannosidase PF17753.1 ACS98925.1 - 6.5e-16 57.9 0.4 1.9e-15 56.4 0.1 2.0 2 0 0 2 2 2 1 Ig-fold domain Glyco_hydro_2 PF00703.21 ACS98925.1 - 6.2e-12 46.2 0.1 1.4e-11 45.0 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Mannosidase_ig PF17786.1 ACS98925.1 - 2.5e-08 34.4 0.0 1e-07 32.5 0.0 2.1 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_C PF02836.17 ACS98925.1 - 0.0019 17.4 0.2 0.012 14.8 0.2 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glycos_transf_2 PF00535.26 ACS98927.1 - 6.3e-24 84.7 0.0 8.4e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACS98927.1 - 3.4e-17 63.1 0.0 1.3e-16 61.2 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ACS98927.1 - 1.2e-11 44.4 0.0 1.9e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 ACS98927.1 - 2.4e-05 23.9 0.0 5.6e-05 22.7 0.0 1.5 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ACS98927.1 - 0.00019 21.4 0.1 0.00033 20.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_4 PF13704.6 ACS98927.1 - 0.0002 21.8 0.0 0.00033 21.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 G3P_acyltransf PF02660.15 ACS98928.1 - 2.1e-32 112.4 11.4 2.6e-32 112.2 11.4 1.0 1 0 0 1 1 1 1 Glycerol-3-phosphate acyltransferase PSII_BNR PF14870.6 ACS98929.1 - 5.9e-13 48.7 16.0 1.3e-07 31.2 2.2 3.7 2 2 1 3 3 3 3 Photosynthesis system II assembly factor YCF48 Sortilin-Vps10 PF15902.5 ACS98929.1 - 7.8e-13 48.0 5.7 1.9e-07 30.3 0.0 3.4 3 1 0 3 3 3 3 Sortilin, neurotensin receptor 3, BNR PF02012.20 ACS98929.1 - 1.4e-08 33.5 36.3 0.28 11.3 1.4 8.1 7 0 0 7 7 7 6 BNR/Asp-box repeat CHB_HEX_C PF03174.13 ACS98929.1 - 0.012 15.6 2.6 20 5.2 0.0 5.6 7 0 0 7 7 7 0 Chitobiase/beta-hexosaminidase C-terminal domain SpoIIIAH PF12685.7 ACS98929.1 - 0.067 13.0 2.7 0.12 12.2 2.7 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF4576 PF15144.6 ACS98929.1 - 0.23 11.4 0.3 1.4 8.8 0.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4576) LPAM_1 PF08139.12 ACS98929.1 - 1.6 9.4 4.0 3.3 8.4 4.0 1.6 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Big_5 PF13205.6 ACS98930.1 - 6.6e-79 261.6 57.0 1.5e-18 67.4 2.3 6.5 7 0 0 7 7 7 5 Bacterial Ig-like domain CopC PF04234.12 ACS98930.1 - 2.3e-13 51.0 15.5 0.013 16.6 0.0 6.0 6 0 0 6 6 6 5 CopC domain Dockerin_1 PF00404.18 ACS98930.1 - 2.3e-09 37.3 2.4 5.8e-09 36.0 1.4 2.3 2 0 0 2 2 2 1 Dockerin type I domain NTS_2 PF15448.6 ACS98930.1 - 0.0031 17.9 0.8 0.3 11.5 0.5 2.7 2 0 0 2 2 2 1 N-terminal segments of P. falciparum erythrocyte membrane protein fn3 PF00041.21 ACS98930.1 - 0.0055 17.0 1.3 1.9 8.9 0.0 4.3 5 0 0 5 5 5 1 Fibronectin type III domain SCAB-Ig PF16709.5 ACS98930.1 - 0.13 12.3 0.0 0.57 10.3 0.0 2.1 1 0 0 1 1 1 0 Ig domain of plant-specific actin-binding protein Porphyrn_cat_1 PF18206.1 ACS98930.1 - 0.3 11.7 4.7 0.68 10.6 0.0 3.4 4 0 0 4 4 4 0 Porphyranase catalytic subdomain 1 EF-hand_6 PF13405.6 ACS98930.1 - 0.44 10.6 1.7 40 4.5 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain SLH PF00395.20 ACS98931.1 - 1.6e-35 120.8 1.5 1.4e-11 44.2 0.0 3.7 3 0 0 3 3 3 3 S-layer homology domain Cohesin PF00963.18 ACS98931.1 - 6.6e-18 65.3 0.5 6.6e-18 65.3 0.5 2.1 2 1 0 2 2 2 1 Cohesin domain OMP_b-brl PF13505.6 ACS98931.1 - 0.045 13.9 0.5 0.39 10.8 0.0 2.5 3 0 0 3 3 3 0 Outer membrane protein beta-barrel domain DUF3244 PF11589.8 ACS98931.1 - 6 7.0 6.7 15 5.7 0.3 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF3244) Cass2 PF14526.6 ACS98932.1 - 9.3e-31 107.0 0.9 1.8e-30 106.1 0.9 1.5 1 0 0 1 1 1 1 Integron-associated effector binding protein GyrI-like PF06445.15 ACS98932.1 - 1.4e-26 93.6 1.1 2.2e-26 93.0 1.1 1.3 1 0 0 1 1 1 1 GyrI-like small molecule binding domain HTH_18 PF12833.7 ACS98932.1 - 5.7e-21 74.6 1.3 9.1e-21 73.9 1.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS98932.1 - 5.1e-14 51.9 0.1 3.2e-06 27.1 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family VHP PF02209.19 ACS98932.1 - 0.65 10.1 2.7 5.6 7.1 0.2 3.2 3 0 0 3 3 3 0 Villin headpiece domain Aldo_ket_red PF00248.21 ACS98933.1 - 5.3e-57 193.3 0.0 8.8e-57 192.5 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family Patatin PF01734.22 ACS98934.1 - 1.1e-22 81.2 0.2 4.1e-22 79.4 0.2 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase EF-G-binding_N PF07299.11 ACS98935.1 - 2.9e-25 88.6 0.1 4.9e-25 87.9 0.1 1.4 1 0 0 1 1 1 1 Elongation factor G-binding protein, N-terminal FBP_C PF16571.5 ACS98935.1 - 5.7e-12 45.4 0.0 9.9e-12 44.6 0.0 1.3 1 0 0 1 1 1 1 FBP C-terminal treble-clef zinc-finger DXP_synthase_N PF13292.6 ACS98935.1 - 0.11 11.7 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase DUF4395 PF14340.6 ACS98936.1 - 6.4e-26 91.2 10.3 7.6e-26 91.0 10.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4395) DUF1201 PF06716.11 ACS98936.1 - 0.0067 16.4 0.4 0.0067 16.4 0.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1201) DUF1129 PF06570.11 ACS98936.1 - 0.54 9.7 3.7 1.1 8.8 1.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) DUF3040 PF11239.8 ACS98936.1 - 1.3 9.3 5.6 2.1 8.7 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) SLATT_1 PF18181.1 ACS98936.1 - 2 8.4 5.0 0.4 10.6 1.3 1.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 LapA_dom PF06305.11 ACS98936.1 - 3.4 7.5 10.1 0.18 11.6 3.5 2.3 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain HPP PF04982.13 ACS98937.1 - 2.1e-14 53.7 5.8 3e-14 53.3 5.8 1.2 1 0 0 1 1 1 1 HPP family FUSC_2 PF13515.6 ACS98937.1 - 1.3 9.2 14.3 5 7.3 14.2 2.0 1 1 0 1 1 1 0 Fusaric acid resistance protein-like PHO4 PF01384.20 ACS98937.1 - 4.3 6.3 8.4 4.7 6.1 8.4 1.1 1 0 0 1 1 1 0 Phosphate transporter family MatE PF01554.18 ACS98938.1 - 7.5e-40 136.2 38.6 9e-21 74.2 17.2 2.4 2 1 0 2 2 2 2 MatE PNPase PF03726.14 ACS98939.1 - 0.042 14.3 0.2 0.051 14.1 0.2 1.2 1 0 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain ABC_tran PF00005.27 ACS98941.1 - 3.3e-32 111.9 0.0 4.5e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 ACS98941.1 - 1.1e-08 35.4 0.1 2.2e-08 34.5 0.1 1.5 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region SMC_N PF02463.19 ACS98941.1 - 7.9e-06 25.5 0.1 2.9e-05 23.6 0.1 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACS98941.1 - 0.0014 18.5 0.1 0.56 10.0 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ACS98941.1 - 0.003 17.8 0.0 0.011 15.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACS98941.1 - 0.0044 16.7 0.4 0.0084 15.8 0.4 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ACS98941.1 - 0.024 15.0 0.0 0.039 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 ACS98941.1 - 0.038 13.6 0.2 12 5.4 0.0 2.7 2 1 0 2 2 2 0 AAA domain Med9 PF07544.13 ACS98941.1 - 0.13 12.4 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF87 PF01935.17 ACS98941.1 - 0.16 12.1 0.2 1.7 8.7 0.3 2.1 1 1 1 2 2 2 0 Helicase HerA, central domain ABC_tran PF00005.27 ACS98942.1 - 2.3e-30 105.9 0.0 3.5e-30 105.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 ACS98942.1 - 5.6e-20 71.6 0.1 1.1e-19 70.7 0.1 1.5 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 ACS98942.1 - 1.6e-07 31.4 0.3 4.8e-06 26.6 0.0 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS98942.1 - 0.0001 21.8 0.4 0.00041 19.9 0.4 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACS98942.1 - 0.0034 17.1 0.1 0.0063 16.2 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ACS98942.1 - 0.015 15.6 0.5 0.12 12.6 0.5 2.1 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ACS98942.1 - 0.015 14.7 0.1 0.078 12.4 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF87 PF01935.17 ACS98942.1 - 0.019 15.1 0.2 0.075 13.1 0.1 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 ACS98942.1 - 0.019 14.5 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 ACS98942.1 - 0.044 13.2 0.1 0.67 9.3 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Sigma54_activat PF00158.26 ACS98942.1 - 0.046 13.4 0.2 0.16 11.6 0.1 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.6 ACS98942.1 - 0.069 13.5 0.0 0.13 12.7 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Myosin_head PF00063.21 ACS98942.1 - 0.23 9.6 0.0 0.34 9.1 0.0 1.2 1 0 0 1 1 1 0 Myosin head (motor domain) ABC_ATPase PF09818.9 ACS98942.1 - 0.54 9.0 2.0 4.1 6.1 0.1 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class BPD_transp_1 PF00528.22 ACS98943.1 - 6.2e-31 107.6 15.9 6.2e-31 107.6 15.9 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 ACS98943.1 - 8.5e-05 22.5 0.3 8.5e-05 22.5 0.3 3.7 4 0 0 4 4 4 1 N-terminal TM domain of oligopeptide transport permease C DUF3482 PF11981.8 ACS98943.1 - 0.0093 15.4 0.2 0.014 14.8 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3482) BPD_transp_1 PF00528.22 ACS98944.1 - 2.3e-43 148.1 12.4 2.3e-43 148.1 12.4 1.5 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Mid2 PF04478.12 ACS98944.1 - 0.18 11.6 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor SBP_bac_5 PF00496.22 ACS98945.1 - 2e-84 283.7 7.1 3e-84 283.2 7.1 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle Response_reg PF00072.24 ACS98948.1 - 2.4e-27 95.3 0.0 7.8e-27 93.7 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACS98948.1 - 1.5e-23 82.3 1.4 3.7e-11 42.8 0.2 3.0 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACS98948.1 - 9.8e-22 77.0 0.0 2.6e-21 75.6 0.0 1.8 1 1 0 1 1 1 1 Helix-turn-helix domain WXG100 PF06013.12 ACS98948.1 - 0.0027 17.9 0.1 0.0091 16.2 0.1 1.9 1 0 0 1 1 1 1 Proteins of 100 residues with WXG HTH_Tnp_1_2 PF13022.6 ACS98948.1 - 0.0058 16.8 0.2 11 6.2 0.0 3.4 2 1 1 3 3 3 2 Helix-turn-helix of insertion element transposase UPF0122 PF04297.14 ACS98948.1 - 0.019 15.2 0.4 0.019 15.2 0.4 2.1 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like SRA PF18491.1 ACS98948.1 - 0.024 14.7 0.0 0.053 13.6 0.0 1.5 1 0 0 1 1 1 0 SET and RING associated domain His_kinase PF06580.13 ACS98949.1 - 1.1e-20 73.8 2.4 1.1e-20 73.8 2.4 2.3 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACS98949.1 - 1.6e-14 54.3 4.3 1.6e-14 54.3 4.3 1.7 2 0 0 2 2 2 1 Cache domain HAMP PF00672.25 ACS98949.1 - 4.3e-14 52.6 1.2 7.6e-14 51.8 0.4 1.9 2 0 0 2 2 2 1 HAMP domain HATPase_c PF02518.26 ACS98949.1 - 3.2e-09 37.3 0.0 7.6e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACS98949.1 - 0.062 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RICH PF05062.12 ACS98949.1 - 0.16 12.4 1.2 0.49 10.8 0.4 2.2 1 1 1 2 2 2 0 RICH domain BPD_transp_1 PF00528.22 ACS98950.1 - 1e-14 54.7 11.8 1e-14 54.7 11.8 1.7 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF373 PF04123.13 ACS98950.1 - 0.35 10.3 7.7 2 7.8 7.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF373) MNHE PF01899.16 ACS98950.1 - 0.39 10.5 7.0 1.1 9.1 7.0 1.8 1 0 0 1 1 1 0 Na+/H+ ion antiporter subunit BPD_transp_1 PF00528.22 ACS98951.1 - 1.8e-16 60.4 12.8 1.8e-16 60.4 12.8 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Comm PF15957.5 ACS98951.1 - 1.1 9.7 3.5 0.53 10.7 0.6 2.0 2 0 0 2 2 2 0 Commissureless SBP_bac_1 PF01547.25 ACS98952.1 - 8.4e-17 62.1 11.9 8.4e-17 62.1 11.9 1.7 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACS98952.1 - 0.0073 16.1 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein TAT_signal PF10518.9 ACS98952.1 - 0.046 13.6 0.8 0.081 12.8 0.8 1.4 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence DivIVA PF05103.13 ACS98952.1 - 0.062 13.4 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 DivIVA protein AHSA1 PF08327.11 ACS98953.1 - 2.4e-18 66.6 1.0 2.7e-18 66.4 1.0 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ACS98953.1 - 4.1e-06 27.1 0.0 4.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport HTH_20 PF12840.7 ACS98954.1 - 9.5e-11 41.6 0.3 1.4e-10 41.1 0.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 ACS98954.1 - 1.5e-09 37.6 0.1 2.2e-09 37.0 0.1 1.2 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.12 ACS98954.1 - 1.4e-05 24.9 0.2 2.4e-05 24.2 0.2 1.4 1 0 0 1 1 1 1 HTH domain HTH_IclR PF09339.10 ACS98954.1 - 0.00029 20.6 0.4 0.00051 19.8 0.4 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.6 ACS98954.1 - 0.002 17.6 0.0 0.0041 16.6 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ACS98954.1 - 0.0035 17.2 0.4 0.0049 16.7 0.4 1.2 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.20 ACS98954.1 - 0.0058 17.0 0.1 0.0084 16.4 0.1 1.2 1 0 0 1 1 1 1 Transcriptional regulator GntR PF00392.21 ACS98954.1 - 0.0087 15.7 0.2 0.014 15.1 0.2 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family RP-C PF03428.13 ACS98954.1 - 0.018 14.7 0.3 0.07 12.8 0.1 1.8 1 1 1 2 2 2 0 Replication protein C N-terminal domain HTH_27 PF13463.6 ACS98954.1 - 0.024 15.1 0.1 0.039 14.4 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain PuR_N PF09182.10 ACS98954.1 - 0.038 13.9 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal TetR_C_30 PF17939.1 ACS98954.1 - 0.081 13.2 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Cdc6_C PF09079.11 ACS98954.1 - 0.095 12.7 0.0 0.28 11.2 0.0 1.7 1 1 1 2 2 2 0 CDC6, C terminal winged helix domain PaaX PF07848.12 ACS98954.1 - 0.18 12.0 0.5 0.52 10.6 0.5 1.8 1 1 0 1 1 1 0 PaaX-like protein DoxX_2 PF13564.6 ACS98955.1 - 7.9e-20 70.9 4.5 1.1e-19 70.5 4.5 1.2 1 0 0 1 1 1 1 DoxX-like family SLH PF00395.20 ACS98957.1 - 6.1e-35 119.0 3.2 3.3e-11 43.0 0.0 3.5 3 0 0 3 3 3 3 S-layer homology domain Cohesin PF00963.18 ACS98957.1 - 2.6e-09 37.5 1.0 2.6e-09 37.5 1.0 2.4 3 0 0 3 3 3 1 Cohesin domain Amidase PF01425.21 ACS98958.1 - 5.7e-104 348.6 0.0 4.3e-103 345.7 0.0 1.9 1 1 0 1 1 1 1 Amidase Cohesin PF00963.18 ACS98958.1 - 2.8e-10 40.6 4.2 7.4e-10 39.2 4.2 1.7 1 0 0 1 1 1 1 Cohesin domain Dockerin_1 PF00404.18 ACS98958.1 - 0.00032 20.8 3.4 0.00032 20.8 3.4 2.4 2 0 0 2 2 2 1 Dockerin type I domain DUF3251 PF11622.8 ACS98958.1 - 0.018 14.7 0.2 0.036 13.7 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Flavodoxin_2 PF02525.17 ACS98959.1 - 2.2e-42 145.1 0.0 2.7e-42 144.7 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ACS98959.1 - 0.00028 20.6 0.0 0.00051 19.8 0.0 1.4 1 0 0 1 1 1 1 NADPH-dependent FMN reductase RBD-FIP PF09457.10 ACS98959.1 - 0.028 14.3 0.3 0.083 12.8 0.3 1.9 1 1 0 1 1 1 0 FIP domain DUF5395 PF17373.2 ACS98959.1 - 0.11 13.2 0.1 0.38 11.4 0.0 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5395) Rrf2 PF02082.20 ACS98960.1 - 5.6e-24 84.3 0.0 8.3e-24 83.8 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator MarR PF01047.22 ACS98960.1 - 0.035 14.1 0.0 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 MarR family DinB_2 PF12867.7 ACS98961.1 - 1.7e-14 54.5 0.1 2e-14 54.2 0.1 1.1 1 0 0 1 1 1 1 DinB superfamily DUF1569 PF07606.11 ACS98961.1 - 1.8e-05 24.7 0.6 0.0012 18.9 0.1 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF1569) MDMPI_N PF11716.8 ACS98961.1 - 0.0082 16.8 0.0 0.024 15.3 0.0 1.8 1 1 1 2 2 2 1 Mycothiol maleylpyruvate isomerase N-terminal domain Malate_DH PF12434.8 ACS98961.1 - 0.016 15.3 0.2 0.033 14.2 0.2 1.5 1 0 0 1 1 1 0 Malate dehydrogenase enzyme DUF1706 PF08020.11 ACS98961.1 - 0.076 12.9 0.0 0.4 10.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1706) WYL PF13280.6 ACS98962.1 - 1.7e-40 138.9 0.1 2.4e-40 138.4 0.1 1.2 1 0 0 1 1 1 1 WYL domain HTH_11 PF08279.12 ACS98962.1 - 1.8e-12 47.0 0.0 3.9e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 HTH domain HTH_DeoR PF08220.12 ACS98962.1 - 6.5e-05 22.6 0.1 0.00016 21.4 0.1 1.6 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain ORF6N PF10543.9 ACS98962.1 - 0.15 12.3 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 ORF6N domain SBP_bac_11 PF13531.6 ACS98964.1 - 5e-15 55.9 2.8 6.1e-13 49.1 0.0 2.4 1 1 1 2 2 2 2 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACS98964.1 - 6.5e-15 55.9 10.1 1.1e-14 55.1 10.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACS98964.1 - 9.1e-08 31.8 0.4 1.9e-07 30.8 0.4 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein PBP_like_2 PF12849.7 ACS98964.1 - 0.0011 18.8 1.7 0.0033 17.2 1.6 2.0 1 1 0 1 1 1 1 PBP superfamily domain TBPIP_N PF15517.6 ACS98964.1 - 0.024 14.7 0.1 0.55 10.3 0.0 2.4 2 0 0 2 2 2 0 TBP-interacting protein N-terminus BPD_transp_1 PF00528.22 ACS98965.1 - 2.5e-28 99.1 48.1 9.2e-15 54.9 15.8 3.6 4 0 0 4 4 4 3 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 ACS98966.1 - 6.2e-35 120.7 0.0 1.2e-34 119.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS98966.1 - 7.6e-09 35.8 0.0 0.004 17.0 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 ACS98966.1 - 2.3e-06 28.1 0.3 0.0011 19.4 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ACS98966.1 - 5.3e-05 23.7 0.2 0.00017 22.0 0.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ACS98966.1 - 0.0001 22.2 0.2 0.00025 21.0 0.1 1.7 2 0 0 2 2 2 1 RsgA GTPase TOBE PF03459.17 ACS98966.1 - 0.00037 20.7 0.0 0.0049 17.1 0.0 2.5 2 0 0 2 2 2 1 TOBE domain TOBE_2 PF08402.10 ACS98966.1 - 0.0016 18.5 0.1 0.012 15.8 0.0 2.4 2 0 0 2 2 2 1 TOBE domain AAA_22 PF13401.6 ACS98966.1 - 0.0019 18.5 0.5 0.0063 16.8 0.5 1.8 1 1 0 1 1 1 1 AAA domain CysA_C_terminal PF17850.1 ACS98966.1 - 0.002 18.6 0.3 0.016 15.8 0.1 2.5 2 0 0 2 2 2 1 CysA C-terminal regulatory domain SMC_N PF02463.19 ACS98966.1 - 0.0035 16.8 0.2 0.12 11.8 0.1 2.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 ACS98966.1 - 0.0054 17.0 0.2 0.019 15.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ACS98966.1 - 0.021 14.5 0.4 0.1 12.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ACS98966.1 - 0.022 14.5 2.0 2.4 7.7 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain NACHT PF05729.12 ACS98966.1 - 0.023 14.6 0.1 0.064 13.2 0.1 1.8 1 0 0 1 1 1 0 NACHT domain ATP-synt_ab PF00006.25 ACS98966.1 - 0.026 14.2 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_5 PF07728.14 ACS98966.1 - 0.028 14.4 0.4 0.53 10.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 ACS98966.1 - 0.041 13.8 0.0 0.079 12.9 0.0 1.5 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 ACS98966.1 - 0.042 13.0 0.1 0.077 12.2 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.6 ACS98966.1 - 0.043 13.6 0.1 0.092 12.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain OB_MalK PF17912.1 ACS98966.1 - 0.055 14.3 0.0 1 10.3 0.0 3.0 1 1 0 1 1 1 0 MalK OB fold domain ATPase PF06745.13 ACS98966.1 - 0.063 12.6 0.4 3.7 6.8 0.0 2.2 2 0 0 2 2 2 0 KaiC Rad17 PF03215.15 ACS98966.1 - 0.071 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain PduV-EutP PF10662.9 ACS98966.1 - 0.11 12.3 0.2 0.4 10.4 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 ACS98966.1 - 0.11 12.7 0.3 0.24 11.6 0.3 1.7 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 ACS98966.1 - 0.12 11.8 1.3 1 8.7 0.2 2.3 1 1 1 2 2 2 0 PhoH-like protein PDDEXK_10 PF07788.11 ACS98966.1 - 0.13 12.2 0.0 8.1 6.5 0.0 2.5 2 0 0 2 2 2 0 PD-(D/E)XK nuclease superfamily AAA_23 PF13476.6 ACS98966.1 - 0.16 12.5 0.2 0.28 11.7 0.2 1.4 1 1 0 1 1 1 0 AAA domain PHP_C PF13263.6 ACS98967.1 - 2.1e-14 53.0 0.0 3.4e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 PHP-associated PHP PF02811.19 ACS98967.1 - 1e-08 35.7 0.2 4.1e-08 33.7 0.2 2.0 1 1 0 1 1 1 1 PHP domain FlgM PF04316.13 ACS98967.1 - 0.07 13.5 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM Disaggr_assoc PF08480.10 ACS98967.1 - 0.098 12.5 0.1 3.6 7.4 0.1 2.3 2 0 0 2 2 2 0 Disaggregatase related HTH_6 PF01418.17 ACS98968.1 - 1.2e-09 38.0 0.1 6.6e-08 32.4 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain, rpiR family SIS PF01380.22 ACS98968.1 - 1e-08 35.1 0.0 1.6e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 SIS domain LacI PF00356.21 ACS98968.1 - 0.00037 20.2 0.0 0.00083 19.1 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Crp PF00325.20 ACS98968.1 - 0.013 15.2 0.2 0.18 11.5 0.1 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family HTH_23 PF13384.6 ACS98968.1 - 0.019 14.8 0.0 0.052 13.4 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Crp_2 PF13545.6 ACS98968.1 - 0.045 13.7 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain AAA_23 PF13476.6 ACS98969.1 - 1.4e-12 48.6 32.0 1.4e-12 48.6 32.0 3.4 3 2 0 3 3 2 1 AAA domain SMC_N PF02463.19 ACS98969.1 - 4.5e-07 29.5 19.6 2.6e-06 27.0 19.6 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACS98969.1 - 0.0013 18.4 0.1 0.0025 17.5 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain NPV_P10 PF05531.12 ACS98969.1 - 0.0065 16.9 8.1 0.019 15.4 0.8 3.4 2 1 0 2 2 2 1 Nucleopolyhedrovirus P10 protein TMCCDC2 PF15844.5 ACS98969.1 - 0.028 14.4 3.0 0.03 14.3 0.6 2.3 2 0 0 2 2 2 0 Transmembrane and coiled-coil domain-containing protein 2 FlaC_arch PF05377.11 ACS98969.1 - 0.046 14.1 0.6 0.046 14.1 0.6 4.2 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) ABC_tran PF00005.27 ACS98969.1 - 0.076 13.5 0.0 0.076 13.5 0.0 2.8 2 1 0 2 2 1 0 ABC transporter LMBR1 PF04791.16 ACS98969.1 - 0.13 11.1 15.1 0.56 9.1 4.3 2.2 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF1664 PF07889.12 ACS98969.1 - 0.18 11.8 16.0 0.033 14.2 1.4 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) AAA_15 PF13175.6 ACS98969.1 - 0.28 10.8 65.7 5.1e+02 0.1 59.4 2.9 2 1 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 ACS98969.1 - 0.3 11.0 0.0 0.3 11.0 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase DUF4407 PF14362.6 ACS98969.1 - 0.35 10.2 12.3 0.25 10.7 2.3 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 ACS98969.1 - 0.6 10.4 2.4 30 5.0 0.2 3.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4315 PF14193.6 ACS98969.1 - 4.8 7.3 22.1 0.32 11.0 0.6 4.3 3 2 0 3 3 3 0 Domain of unknown function (DUF4315) DUF3378 PF11858.8 ACS98971.1 - 0.11 12.7 0.5 0.35 11.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) N6_N4_Mtase PF01555.18 ACS98972.1 - 8.7e-12 45.2 0.0 1.3e-05 25.0 0.0 2.8 2 1 0 2 2 2 2 DNA methylase UPF0020 PF01170.18 ACS98972.1 - 0.0017 18.1 0.0 2.2 7.9 0.0 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 DUF2291 PF10054.9 ACS98972.1 - 0.04 13.6 0.0 0.098 12.4 0.0 1.6 1 0 0 1 1 1 0 Predicted periplasmic lipoprotein (DUF2291) DUF3427 PF11907.8 ACS98973.1 - 9.4e-32 110.4 1.7 1.6e-31 109.7 0.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3427) ResIII PF04851.15 ACS98973.1 - 8.7e-30 104.0 0.0 2.6e-29 102.4 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PLDc_2 PF13091.6 ACS98973.1 - 4e-14 52.6 0.0 8.5e-14 51.6 0.0 1.6 1 0 0 1 1 1 1 PLD-like domain Helicase_C PF00271.31 ACS98973.1 - 1.1e-10 41.8 0.0 4.4e-10 39.9 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SWI2_SNF2 PF18766.1 ACS98973.1 - 2.3e-08 34.0 0.0 5e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase RE_NgoFVII PF09565.10 ACS98973.1 - 4.6e-07 29.5 0.2 8.7e-07 28.5 0.2 1.4 1 0 0 1 1 1 1 NgoFVII restriction endonuclease DEAD PF00270.29 ACS98973.1 - 1.7e-06 27.9 0.0 4.1e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase NUDIX PF00293.28 ACS98974.1 - 1.1e-17 64.3 0.0 1.3e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 ACS98974.1 - 7.2e-14 51.7 0.0 8.5e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 ACS98974.1 - 0.084 12.4 0.0 0.09 12.4 0.0 1.2 1 0 0 1 1 1 0 Nucleotide hydrolase CDC45 PF02724.14 ACS98975.1 - 0.09 11.1 0.0 0.096 11.0 0.0 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF1192 PF06698.11 ACS98975.1 - 0.15 12.1 0.1 5.4 7.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) NPCBM PF08305.11 ACS98976.1 - 2.6e-17 63.3 0.7 3.1e-17 63.1 0.7 1.1 1 0 0 1 1 1 1 NPCBM/NEW2 domain Bac_rhamnosid6H PF17389.2 ACS98977.1 - 1.9e-99 333.1 0.0 2.6e-99 332.7 0.0 1.2 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 ACS98977.1 - 6.8e-53 179.0 0.2 3.8e-50 170.1 0.1 3.2 2 1 0 2 2 2 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 ACS98977.1 - 6e-28 96.8 0.0 1.1e-27 96.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_C PF17390.2 ACS98977.1 - 3.6e-11 42.7 0.0 8.3e-11 41.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain DUF4965 PF16335.5 ACS98977.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4965) PTS_2-RNA PF01885.16 ACS98978.1 - 2.1e-34 119.2 0.0 2.6e-34 118.9 0.0 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family PARP PF00644.20 ACS98978.1 - 2.5e-05 24.0 0.0 3.6e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain TatD_DNase PF01026.21 ACS98979.1 - 2.3e-70 236.9 0.0 2.6e-70 236.7 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 ACS98979.1 - 0.09 12.5 0.1 0.16 11.7 0.1 1.5 1 1 0 1 1 1 0 Amidohydrolase CSD PF00313.22 ACS98982.1 - 2.1e-31 107.6 3.0 2.3e-31 107.4 3.0 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 ACS98982.1 - 0.0031 17.1 1.3 0.0039 16.8 1.3 1.5 1 1 0 1 1 1 1 Ribonuclease B OB domain YdjO PF14169.6 ACS98983.1 - 1e-28 98.8 2.7 1.2e-28 98.6 2.7 1.0 1 0 0 1 1 1 1 Cold-inducible protein YdjO Cytochrom_B561 PF03188.16 ACS98984.1 - 0.049 13.8 1.6 0.058 13.5 1.6 1.1 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 FhuF_C PF11575.8 ACS98985.1 - 3.9e-05 23.5 8.8 6e-05 22.9 6.2 2.3 2 0 0 2 2 2 1 FhuF 2Fe-2S C-terminal domain FhuF PF06276.12 ACS98985.1 - 0.02 15.3 0.1 0.03 14.7 0.1 1.3 1 0 0 1 1 1 0 Ferric iron reductase FhuF-like transporter GerA PF03323.13 ACS98986.1 - 1e-123 413.3 8.6 1.3e-123 413.0 8.6 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein LysR_substrate PF03466.20 ACS98987.1 - 3.7e-21 75.5 0.0 4.9e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACS98987.1 - 1.9e-16 59.7 0.0 4e-16 58.7 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like_2 PF12849.7 ACS98987.1 - 0.081 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 PBP superfamily domain adh_short_C2 PF13561.6 ACS98988.1 - 4e-72 242.5 4.4 4.6e-72 242.3 4.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACS98988.1 - 4.9e-61 205.6 4.9 5.9e-61 205.3 4.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACS98988.1 - 5.5e-14 52.5 0.3 8.6e-14 51.8 0.2 1.3 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ACS98988.1 - 6.2e-05 23.0 1.9 0.00058 19.8 0.4 2.1 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 ACS98988.1 - 0.0021 18.1 0.3 0.0039 17.3 0.3 1.6 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ACS98988.1 - 0.0034 17.0 0.3 0.006 16.2 0.3 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_25 PF13649.6 ACS98988.1 - 0.03 15.0 0.1 0.072 13.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain DUF1776 PF08643.10 ACS98988.1 - 0.053 12.9 0.0 0.071 12.5 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) 2-Hacid_dh_C PF02826.19 ACS98988.1 - 0.09 12.1 0.6 0.15 11.4 0.6 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 ACS98989.1 - 4.3e-72 242.5 2.2 5e-72 242.2 2.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACS98989.1 - 2.8e-57 193.4 4.2 3.2e-57 193.1 4.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACS98989.1 - 4.7e-10 39.7 2.5 6.7e-10 39.2 2.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACS98989.1 - 7.8e-05 22.2 0.2 0.0043 16.5 0.2 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Phage_Capsid_P3 PF09018.11 ACS98989.1 - 0.014 14.2 0.1 0.017 14.0 0.1 1.2 1 0 0 1 1 1 0 P3 major capsid protein M20_dimer PF07687.14 ACS98989.1 - 0.044 13.7 0.0 0.73 9.8 0.0 2.2 2 0 0 2 2 2 0 Peptidase dimerisation domain Glycos_transf_3 PF00591.21 ACS98990.1 - 0.0064 16.1 0.5 0.0077 15.9 0.5 1.0 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain RRM_9 PF18444.1 ACS98990.1 - 0.024 14.5 0.1 2.6 8.0 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif DUF2949 PF11165.8 ACS98990.1 - 0.048 14.0 0.1 0.091 13.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2949) A_thal_3526 PF09713.10 ACS98990.1 - 0.097 12.9 0.3 0.58 10.4 0.1 2.1 2 0 0 2 2 2 0 Plant protein 1589 of unknown function (A_thal_3526) DUF4777 PF16007.5 ACS98990.1 - 0.13 12.5 0.5 14 6.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4777) YibE_F PF07907.11 ACS98991.1 - 3.9e-76 255.7 30.3 3.9e-76 255.7 30.3 1.5 2 0 0 2 2 2 1 YibE/F-like protein HupE_UreJ_2 PF13795.6 ACS98992.1 - 5.2e-48 162.6 12.2 8e-48 162.0 12.2 1.3 1 0 0 1 1 1 1 HupE / UreJ protein DUF3165 PF11364.8 ACS98992.1 - 8.4 6.8 7.3 1.4 9.3 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3165) Metallophos PF00149.28 ACS98993.1 - 1.2e-17 65.1 0.3 2.6e-17 64.0 0.1 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 ACS98993.1 - 9.3e-15 55.0 1.3 9.3e-15 55.0 1.3 2.5 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Big_3 PF07523.12 ACS98993.1 - 2.7e-11 43.6 2.5 2.7e-11 43.6 2.5 2.9 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 3) Dockerin_1 PF00404.18 ACS98993.1 - 7.2e-06 26.1 1.0 4e-05 23.7 1.0 2.4 1 0 0 1 1 1 1 Dockerin type I domain EF-hand_4 PF12763.7 ACS98993.1 - 0.29 11.1 1.4 1.9 8.5 0.1 2.5 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand SLH PF00395.20 ACS98994.1 - 8.3e-36 121.7 5.2 3.1e-12 46.3 0.3 3.5 3 0 0 3 3 3 3 S-layer homology domain PdaC PF13739.6 ACS98995.1 - 1.3e-23 83.8 0.2 3.2e-23 82.5 0.2 1.7 1 0 0 1 1 1 1 Deacetylase PdaC Cu_amine_oxidN1 PF07833.11 ACS98995.1 - 2.2e-19 69.8 0.3 1.6e-18 67.0 0.1 2.2 2 0 0 2 2 2 1 Copper amine oxidase N-terminal domain DUF3298 PF11738.8 ACS98995.1 - 4e-06 27.8 1.1 7.2e-05 23.7 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3298) Glyoxalase PF00903.25 ACS98996.1 - 0.00062 20.0 0.1 0.001 19.3 0.1 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Sigma70_r4 PF04545.16 ACS98996.1 - 0.062 12.8 0.0 0.088 12.3 0.0 1.2 1 0 0 1 1 1 0 Sigma-70, region 4 Glyco_hydro_3 PF00933.21 ACS98997.1 - 3.1e-81 273.2 0.0 4.2e-81 272.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ACS98997.1 - 4.6e-53 180.2 0.0 7.2e-53 179.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ACS98997.1 - 6.1e-21 74.3 0.1 1.5e-20 73.1 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain FAD_binding_4 PF01565.23 ACS98997.1 - 0.0061 16.3 0.0 0.1 12.3 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain DUF11 PF01345.18 ACS98997.1 - 0.0087 16.3 0.8 0.11 12.8 1.0 2.4 2 1 0 2 2 2 1 Domain of unknown function DUF11 PTS-HPr PF00381.19 ACS98997.1 - 0.17 12.2 1.2 0.51 10.6 0.6 2.2 2 0 0 2 2 2 0 PTS HPr component phosphorylation site AA_permease_2 PF13520.6 ACS98998.1 - 6.9e-35 120.7 44.9 9.4e-35 120.3 44.9 1.1 1 0 0 1 1 1 1 Amino acid permease K_trans PF02705.16 ACS98998.1 - 0.00068 18.3 18.8 0.001 17.7 9.4 2.4 2 0 0 2 2 2 2 K+ potassium transporter MMPL PF03176.15 ACS98999.1 - 6.5e-105 350.7 21.7 7.6e-58 196.0 2.9 2.4 2 1 0 2 2 2 2 MMPL family Sterol-sensing PF12349.8 ACS98999.1 - 1.3e-07 31.6 15.5 0.00016 21.5 0.9 2.4 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation DUF4661 PF15576.6 ACS98999.1 - 0.045 13.7 0.0 0.099 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) TetR_N PF00440.23 ACS99000.1 - 2.4e-16 59.2 0.0 4.4e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HAD_2 PF13419.6 ACS99000.1 - 0.15 12.1 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Aldo_ket_red PF00248.21 ACS99001.1 - 1.7e-50 171.9 0.4 2.2e-48 165.0 0.4 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.16 ACS99002.1 - 5.8e-47 160.3 49.8 4.5e-43 147.5 40.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ACS99002.1 - 7.7e-12 45.2 36.0 9.5e-12 44.9 36.0 1.0 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 ACS99002.1 - 1.3e-10 40.7 35.5 2.7e-09 36.4 14.0 3.1 1 1 2 3 3 3 2 Sugar (and other) transporter MFS_1_like PF12832.7 ACS99002.1 - 0.49 9.2 27.2 0.064 12.1 7.7 2.1 1 1 1 2 2 2 0 MFS_1 like family HxlR PF01638.17 ACS99003.1 - 1.3e-39 134.0 0.0 1.6e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.14 ACS99003.1 - 0.029 14.3 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family MarR PF01047.22 ACS99003.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 MarR family DUF11 PF01345.18 ACS99004.1 - 3.6e-57 190.6 52.3 1.1e-10 41.6 0.8 7.9 7 0 0 7 7 7 7 Domain of unknown function DUF11 bMG10 PF17973.1 ACS99004.1 - 2.7e-06 27.6 11.5 0.33 11.1 0.0 6.6 8 0 0 8 8 8 3 Bacterial Alpha-2-macroglobulin MG10 domain Collagen_bind PF05737.12 ACS99004.1 - 5.1e-05 23.5 0.5 1.5 9.0 0.0 4.8 4 0 0 4 4 4 2 Collagen binding domain CARDB PF07705.11 ACS99004.1 - 0.00019 21.6 38.2 0.042 14.1 0.6 8.2 6 2 0 6 6 6 3 CARDB DUF3786 PF12654.7 ACS99004.1 - 0.17 11.5 0.0 0.78 9.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3786) Peptidase_M41 PF01434.18 ACS99006.1 - 1.4e-30 106.6 2.0 3.3e-29 102.1 2.0 2.2 1 1 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ACS99006.1 - 8e-29 100.7 0.0 2.4e-28 99.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ACS99006.1 - 8.7e-07 28.8 0.0 1.9e-06 27.7 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ACS99006.1 - 1.2e-05 25.6 0.0 0.0036 17.6 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ACS99006.1 - 0.0002 21.4 0.0 0.00065 19.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 ACS99006.1 - 0.00033 20.4 0.1 0.00088 19.0 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain IstB_IS21 PF01695.17 ACS99006.1 - 0.00038 20.2 0.0 0.00069 19.4 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 ACS99006.1 - 0.0036 17.7 0.8 0.012 15.9 0.0 2.3 3 1 0 3 3 2 1 AAA ATPase domain TIP49 PF06068.13 ACS99006.1 - 0.0099 15.1 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 ACS99006.1 - 0.017 15.3 0.0 0.051 13.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ACS99006.1 - 0.032 14.6 0.0 0.095 13.1 0.0 1.8 2 0 0 2 2 1 0 RNA helicase NACHT PF05729.12 ACS99006.1 - 0.057 13.3 0.0 0.48 10.3 0.0 2.2 2 0 0 2 2 2 0 NACHT domain Mg_chelatase PF01078.21 ACS99006.1 - 0.077 12.4 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ACS99006.1 - 0.083 13.4 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 ACS99006.1 - 0.094 12.8 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 ACS99006.1 - 0.16 12.0 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ACS99006.1 - 0.18 11.8 0.0 0.5 10.4 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 ACS99006.1 - 0.21 10.7 0.0 0.35 9.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 HAD_2 PF13419.6 ACS99007.1 - 6.8e-17 62.1 0.0 2.9e-16 60.0 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACS99007.1 - 9.9e-08 31.9 0.0 3.2e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 ACS99007.1 - 2.7e-06 27.9 0.1 4.4e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACS99007.1 - 5.5e-05 23.5 0.1 0.00026 21.3 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ACS99007.1 - 0.0012 18.9 0.0 0.033 14.3 0.0 2.3 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase PfkB PF00294.24 ACS99008.1 - 1.4e-65 221.6 0.8 1.6e-65 221.4 0.8 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 ACS99008.1 - 1.4e-09 37.7 0.0 2.4e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Trypsin_2 PF13365.6 ACS99008.1 - 0.039 14.9 0.3 0.14 13.1 0.0 2.0 2 0 0 2 2 2 0 Trypsin-like peptidase domain ADH_zinc_N PF00107.26 ACS99008.1 - 0.07 13.1 1.0 0.73 9.8 0.0 2.9 3 1 0 3 3 3 0 Zinc-binding dehydrogenase Polysacc_deac_1 PF01522.21 ACS99009.1 - 8.4e-39 132.3 0.1 1.1e-38 131.9 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ACS99009.1 - 3.7e-06 26.4 0.0 2.2e-05 23.8 0.0 2.1 1 1 2 3 3 3 1 Glycosyl hydrolase family 57 Polysacc_deac_2 PF04748.13 ACS99009.1 - 0.00081 18.6 0.1 0.0064 15.7 0.0 2.3 2 1 0 2 2 2 1 Divergent polysaccharide deacetylase DUF2334 PF10096.9 ACS99009.1 - 0.012 15.3 1.4 0.076 12.7 0.9 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2334) TetR_N PF00440.23 ACS99009.1 - 0.097 12.5 0.0 31 4.5 0.0 2.9 3 0 0 3 3 3 0 Bacterial regulatory proteins, tetR family UPF0449 PF15136.6 ACS99009.1 - 0.1 13.1 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 DUF4383 PF14325.6 ACS99011.1 - 0.062 13.6 7.2 0.81 10.0 0.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4383) DUF1129 PF06570.11 ACS99011.1 - 0.34 10.4 4.3 0.52 9.8 0.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) SdpI PF13630.6 ACS99011.1 - 0.55 10.4 6.4 1 9.5 0.8 2.1 2 0 0 2 2 2 0 SdpI/YhfL protein family FCD PF07729.12 ACS99012.1 - 3.4e-23 82.4 12.8 5.5e-23 81.7 12.8 1.3 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 ACS99012.1 - 7.9e-20 70.3 0.9 4.5e-19 67.9 0.0 2.3 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family UxuA PF03786.13 ACS99013.1 - 4.7e-160 532.1 0.0 5.3e-160 532.0 0.0 1.0 1 0 0 1 1 1 1 D-mannonate dehydratase (UxuA) AP_endonuc_2 PF01261.24 ACS99013.1 - 2e-13 50.2 0.0 2.9e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Imm70 PF15601.6 ACS99013.1 - 0.037 13.6 0.0 0.07 12.7 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 70 adh_short PF00106.25 ACS99014.1 - 8.1e-45 152.7 0.3 1.2e-44 152.1 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACS99014.1 - 2.8e-42 144.9 0.3 4e-41 141.1 0.3 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACS99014.1 - 2.2e-06 27.7 4.6 2.6e-05 24.2 1.5 2.1 1 1 1 2 2 2 1 KR domain Shikimate_DH PF01488.20 ACS99014.1 - 0.0003 20.9 1.6 0.00066 19.8 1.6 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 ACS99014.1 - 0.0019 18.4 0.3 0.0095 16.1 0.1 2.1 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase THF_DHG_CYH_C PF02882.19 ACS99014.1 - 0.0086 15.4 0.9 0.027 13.8 0.8 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_trans_4_4 PF13579.6 ACS99014.1 - 0.017 15.5 0.2 0.091 13.2 0.3 1.9 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 ACS99014.1 - 0.03 14.3 0.2 0.097 12.7 0.3 1.7 2 0 0 2 2 2 0 Glycosyltransferase Family 4 Epimerase PF01370.21 ACS99014.1 - 0.033 13.6 0.1 0.2 11.1 0.1 1.9 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ACS99014.1 - 0.17 10.9 0.7 0.28 10.2 0.7 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain F420_oxidored PF03807.17 ACS99014.1 - 0.23 12.1 2.3 0.41 11.3 2.3 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 ACS99014.1 - 0.44 10.1 1.8 1.7 8.1 1.4 1.9 2 0 0 2 2 2 0 NmrA-like family Aldo_ket_red PF00248.21 ACS99015.1 - 4.4e-54 183.7 0.0 5.4e-54 183.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MerR_1 PF13411.6 ACS99017.1 - 5.4e-05 23.2 0.0 0.00014 21.9 0.0 1.7 2 0 0 2 2 2 1 MerR HTH family regulatory protein HTH_17 PF12728.7 ACS99017.1 - 0.00056 20.0 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 ACS99017.1 - 0.0011 18.7 0.1 0.0071 16.1 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 ACS99017.1 - 0.0021 18.0 0.3 0.01 15.9 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn helix Serine_rich PF08824.10 ACS99017.1 - 0.014 15.4 0.3 0.041 13.9 0.2 1.8 2 0 0 2 2 2 0 Serine rich protein interaction domain HTH_DeoR PF08220.12 ACS99017.1 - 0.026 14.3 0.1 0.06 13.1 0.1 1.5 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 ACS99017.1 - 0.036 13.5 1.2 0.057 12.8 0.3 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 ACS99017.1 - 0.058 13.5 0.1 0.058 13.5 0.1 3.1 4 0 0 4 4 4 0 Helix-turn-helix domain DUF746 PF05344.11 ACS99017.1 - 0.077 12.8 0.1 0.29 11.0 0.0 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF746) ATG16 PF08614.11 ACS99017.1 - 0.25 11.5 4.8 0.5 10.6 4.8 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) RVT_3 PF13456.6 ACS99017.1 - 1.8 8.4 4.7 1.2 9.0 2.2 1.9 2 0 0 2 2 2 0 Reverse transcriptase-like Xan_ur_permease PF00860.20 ACS99018.1 - 1.3e-55 188.7 50.6 1.5e-55 188.5 50.6 1.1 1 0 0 1 1 1 1 Permease family HTH_18 PF12833.7 ACS99020.1 - 3.7e-18 65.6 2.6 5.3e-18 65.1 1.2 1.9 1 1 1 2 2 2 1 Helix-turn-helix domain AraC_binding PF02311.19 ACS99020.1 - 6.5e-15 55.2 1.3 1.9e-14 53.7 0.2 2.0 1 1 1 2 2 2 1 AraC-like ligand binding domain HTH_AraC PF00165.23 ACS99020.1 - 3.7e-12 46.0 0.1 1.9e-10 40.6 0.0 2.6 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_3 PF05899.12 ACS99020.1 - 0.00061 19.4 0.3 0.003 17.2 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Cupin_2 PF07883.11 ACS99020.1 - 0.049 13.4 1.2 0.13 12.0 0.1 2.2 3 0 0 3 3 3 0 Cupin domain HTH_23 PF13384.6 ACS99020.1 - 0.28 11.0 1.5 18 5.2 0.1 2.6 1 1 1 2 2 2 0 Homeodomain-like domain GFO_IDH_MocA PF01408.22 ACS99021.1 - 3.2e-31 108.6 0.2 6.1e-31 107.7 0.2 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACS99021.1 - 3.2e-08 33.6 0.0 6.1e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACS99021.1 - 0.00081 20.0 0.2 0.0017 19.0 0.2 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ACS99021.1 - 0.00081 19.7 0.3 0.0038 17.5 0.1 2.3 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain ox_reductase_C PF08635.10 ACS99021.1 - 0.1 12.2 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain AP_endonuc_2 PF01261.24 ACS99022.1 - 3.9e-25 88.5 0.0 5.5e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel AP_endonuc_2_N PF07582.12 ACS99022.1 - 0.00085 19.0 0.0 0.0035 17.0 0.0 2.0 2 0 0 2 2 2 1 AP endonuclease family 2 C terminus VitK2_biosynth PF02621.14 ACS99024.1 - 1.5e-87 293.5 0.0 1.7e-87 293.4 0.0 1.0 1 0 0 1 1 1 1 Menaquinone biosynthesis NMT1 PF09084.11 ACS99024.1 - 0.0091 16.0 0.0 0.018 15.0 0.0 1.5 1 1 0 1 1 1 1 NMT1/THI5 like PNP_UDP_1 PF01048.20 ACS99025.1 - 8.2e-22 77.6 2.7 9.5e-22 77.4 2.7 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily XkdW PF09636.10 ACS99026.1 - 0.12 12.5 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 XkdW protein Lactonase PF10282.9 ACS99027.1 - 6e-109 364.4 0.0 6.8e-109 364.3 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller SGL PF08450.12 ACS99027.1 - 0.00047 19.8 0.0 1.8 8.1 0.0 3.6 2 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region SBP56 PF05694.11 ACS99027.1 - 0.011 14.6 0.0 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 56kDa selenium binding protein (SBP56) Arylesterase PF01731.20 ACS99027.1 - 0.13 12.4 0.0 59 3.9 0.0 3.3 3 0 0 3 3 3 0 Arylesterase PD40 PF07676.12 ACS99027.1 - 0.15 12.0 0.0 16 5.6 0.0 2.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat APH_6_hur PF04655.14 ACS99028.1 - 3.7e-48 164.1 0.3 5.1e-48 163.7 0.3 1.1 1 0 0 1 1 1 1 Aminoglycoside/hydroxyurea antibiotic resistance kinase APH PF01636.23 ACS99028.1 - 1.8e-08 34.6 0.3 3.2e-08 33.8 0.3 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family TetR_N PF00440.23 ACS99029.1 - 3.9e-15 55.3 0.5 1.1e-14 53.9 0.2 2.0 3 0 0 3 3 3 1 Bacterial regulatory proteins, tetR family TetR_C_31 PF17940.1 ACS99029.1 - 0.0067 16.6 0.1 0.019 15.2 0.0 1.8 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain PTPlike_phytase PF14566.6 ACS99029.1 - 0.06 13.5 0.2 0.98 9.5 0.0 2.1 2 0 0 2 2 2 0 Inositol hexakisphosphate HTH_Tnp_1_2 PF13022.6 ACS99029.1 - 0.096 12.8 0.0 0.16 12.1 0.0 1.5 1 1 0 1 1 1 0 Helix-turn-helix of insertion element transposase MFS_1 PF07690.16 ACS99030.1 - 8e-54 182.9 51.7 8e-54 182.9 51.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACS99030.1 - 6.6e-10 38.4 32.8 9.1e-09 34.7 12.0 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_3 PF05977.13 ACS99030.1 - 0.0002 19.9 8.2 0.0002 19.9 8.2 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector OATP PF03137.20 ACS99030.1 - 0.0002 19.8 6.4 0.0011 17.4 1.2 3.2 2 1 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Wzz PF02706.15 ACS99031.1 - 9.5e-15 54.7 0.9 9.5e-15 54.7 0.9 1.7 2 0 0 2 2 2 1 Chain length determinant protein GNVR PF13807.6 ACS99031.1 - 8e-06 25.7 3.6 1.1e-05 25.2 0.6 2.4 2 0 0 2 2 2 1 G-rich domain on putative tyrosine kinase AAA_31 PF13614.6 ACS99032.1 - 3.3e-14 53.2 0.0 7.1e-14 52.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 ACS99032.1 - 5e-10 39.5 0.0 8.6e-10 38.8 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain CBP_BcsQ PF06564.12 ACS99032.1 - 1.2e-06 28.1 0.0 1.7e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ParA PF10609.9 ACS99032.1 - 1.6e-06 27.8 0.1 1.1e-05 25.0 0.1 1.9 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase MipZ PF09140.11 ACS99032.1 - 2.3e-05 23.8 0.0 4.9e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.6 ACS99032.1 - 0.0035 17.2 1.9 0.13 12.0 0.5 2.4 2 1 0 2 2 2 1 AAA domain SRP54 PF00448.22 ACS99032.1 - 0.013 15.2 0.2 1.3 8.6 0.0 2.6 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain GTP_EFTU PF00009.27 ACS99032.1 - 0.02 14.5 0.0 0.5 9.9 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain CLP1_P PF16575.5 ACS99032.1 - 0.082 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Polysacc_synt_2 PF02719.15 ACS99033.1 - 2.5e-123 410.9 0.1 4.2e-123 410.2 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 ACS99033.1 - 1.2e-24 87.1 0.0 1.8e-23 83.3 0.0 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ACS99033.1 - 4.6e-16 58.8 0.0 1e-14 54.3 0.0 2.3 1 1 0 1 1 1 1 RmlD substrate binding domain CoA_binding_3 PF13727.6 ACS99033.1 - 7.7e-15 55.3 0.5 2e-14 54.0 0.0 1.9 1 1 1 2 2 2 1 CoA-binding domain GDP_Man_Dehyd PF16363.5 ACS99033.1 - 8.2e-15 55.0 0.0 2e-14 53.7 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ACS99033.1 - 3e-08 33.0 0.0 8.7e-08 31.5 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ACS99033.1 - 1.6e-05 24.2 0.5 0.006 15.8 0.2 2.7 1 1 1 2 2 2 2 Male sterility protein KR PF08659.10 ACS99033.1 - 3.7e-05 23.7 0.2 0.0001 22.3 0.0 1.8 2 0 0 2 2 2 1 KR domain adh_short PF00106.25 ACS99033.1 - 9.2e-05 22.0 0.3 0.00023 20.7 0.0 1.9 2 1 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 ACS99033.1 - 0.00021 21.2 0.4 0.00073 19.5 0.4 1.9 1 1 0 1 1 1 1 NAD(P)H-binding PglD_N PF17836.1 ACS99033.1 - 0.0031 18.1 0.1 0.0096 16.5 0.1 1.9 1 0 0 1 1 1 1 PglD N-terminal domain ApbA PF02558.16 ACS99033.1 - 0.0072 16.0 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DUF3842 PF12953.7 ACS99033.1 - 0.014 15.8 0.0 0.03 14.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) Shikimate_DH PF01488.20 ACS99033.1 - 0.072 13.2 1.8 0.42 10.7 0.0 2.9 3 1 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 ACS99033.1 - 0.075 12.2 0.2 0.27 10.4 0.2 1.9 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Polysacc_synt PF01943.17 ACS99034.1 - 6.2e-22 78.3 18.2 6.2e-22 78.3 18.2 1.9 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.6 ACS99034.1 - 2e-10 40.9 8.5 2e-10 40.9 8.5 4.7 3 1 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Polysacc_synt_3 PF13440.6 ACS99034.1 - 2.2e-08 33.7 18.7 3.5e-06 26.5 0.1 2.9 2 1 0 3 3 3 2 Polysaccharide biosynthesis protein MatE PF01554.18 ACS99034.1 - 0.00061 19.5 12.4 0.00061 19.5 12.4 3.0 2 1 0 3 3 3 2 MatE PS_pyruv_trans PF04230.13 ACS99035.1 - 1.4e-21 77.7 0.0 6.2e-21 75.6 0.0 1.8 1 1 0 1 1 1 1 Polysaccharide pyruvyl transferase Glycos_transf_1 PF00534.20 ACS99036.1 - 3.1e-30 105.0 0.0 4.6e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99036.1 - 1.7e-25 90.0 0.0 8.4e-24 84.5 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACS99036.1 - 1.7e-09 37.9 0.0 3.8e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 EpsG PF14897.6 ACS99037.1 - 0.018 14.4 27.6 0.0067 15.8 24.0 1.9 1 1 1 2 2 2 0 EpsG family Hexapep PF00132.24 ACS99038.1 - 6.9e-11 41.4 12.1 1.3e-07 31.1 4.2 3.6 3 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACS99038.1 - 4.9e-07 29.4 12.4 0.0013 18.5 3.2 3.4 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Glyco_trans_1_4 PF13692.6 ACS99039.1 - 1.1e-19 71.2 0.0 4e-19 69.4 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 ACS99039.1 - 2.3e-18 66.3 0.0 4.1e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ACS99039.1 - 0.0049 17.2 0.0 0.48 10.8 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Epimerase PF01370.21 ACS99040.1 - 2e-52 178.0 0.0 2.4e-52 177.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACS99040.1 - 7e-50 170.3 0.0 1e-49 169.8 0.0 1.2 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ACS99040.1 - 1e-16 60.8 0.0 1.6e-16 60.1 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ACS99040.1 - 2.5e-15 56.3 0.0 3e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ACS99040.1 - 3.5e-13 49.3 0.0 3.4e-12 46.1 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ACS99040.1 - 9.8e-07 28.2 2.2 0.0012 18.1 0.1 2.4 2 1 0 2 2 2 2 Male sterility protein adh_short PF00106.25 ACS99040.1 - 0.0016 18.0 0.0 0.003 17.0 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.6 ACS99040.1 - 0.0024 17.8 0.1 0.013 15.4 0.1 2.1 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACS99040.1 - 0.011 15.3 0.1 0.035 13.7 0.1 1.7 1 1 0 1 1 1 0 NmrA-like family KR PF08659.10 ACS99040.1 - 0.12 12.2 0.5 0.42 10.5 0.5 1.9 1 1 0 1 1 1 0 KR domain Bac_transf PF02397.16 ACS99041.1 - 4.2e-63 212.3 0.0 6.6e-63 211.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial sugar transferase Glycos_transf_1 PF00534.20 ACS99041.1 - 8.7e-37 126.3 0.0 2.2e-36 125.0 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99041.1 - 3.9e-23 82.4 0.2 1.1e-22 80.8 0.2 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ACS99041.1 - 5.8e-18 65.8 0.1 1.8e-17 64.2 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 ACS99041.1 - 7.6e-17 61.6 0.0 1.5e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_transf_4 PF13439.6 ACS99041.1 - 9.6e-16 58.2 0.0 2.1e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 ACS99041.1 - 7.2e-08 32.7 0.1 1.7e-07 31.6 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_28 PF03033.20 ACS99041.1 - 0.011 15.7 0.0 0.033 14.2 0.0 1.7 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Epimerase_2 PF02350.19 ACS99041.1 - 0.045 12.6 0.1 0.13 11.1 0.1 1.6 1 1 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase RVT_thumb PF06817.14 ACS99041.1 - 0.093 12.6 0.1 0.44 10.4 0.0 2.1 2 0 0 2 2 2 0 Reverse transcriptase thumb domain PTS_IIB PF02302.17 ACS99041.1 - 0.14 12.9 0.0 0.37 11.5 0.0 1.8 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIB subunit PglD_N PF17836.1 ACS99042.1 - 3.5e-14 53.2 0.2 7.2e-14 52.2 0.0 1.6 2 0 0 2 2 2 1 PglD N-terminal domain Hexapep PF00132.24 ACS99042.1 - 1.6e-11 43.5 15.5 5.5e-06 25.9 4.2 4.3 3 1 2 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACS99042.1 - 8.3 6.3 15.6 6.8 6.5 3.9 3.6 3 1 1 4 4 4 0 Hexapeptide repeat of succinyl-transferase DegT_DnrJ_EryC1 PF01041.17 ACS99043.1 - 3.7e-97 325.9 0.0 4.2e-97 325.7 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 ACS99043.1 - 3.5e-09 36.3 0.0 5.6e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ACS99043.1 - 0.00045 19.6 0.0 0.00077 18.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 ACS99043.1 - 0.00091 17.9 0.0 0.0015 17.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SepSecS PF05889.13 ACS99043.1 - 0.046 12.4 0.0 0.063 12.0 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS NTP_transferase PF00483.23 ACS99044.1 - 4.2e-32 111.7 0.0 5.1e-32 111.4 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACS99044.1 - 2.6e-07 31.1 0.0 3.4e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glycos_transf_2 PF00535.26 ACS99044.1 - 0.00061 19.6 0.0 0.00092 19.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 IspD PF01128.19 ACS99044.1 - 0.049 13.4 0.0 0.22 11.2 0.0 1.9 2 0 0 2 2 2 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 ACS99044.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase UDPG_MGDP_dh_N PF03721.14 ACS99045.1 - 8.4e-68 227.6 0.3 1.4e-67 226.9 0.3 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 ACS99045.1 - 2.6e-41 139.7 0.2 8.8e-41 138.0 0.1 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 ACS99045.1 - 4.5e-34 117.0 0.0 3.3e-32 111.0 0.0 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 3HCDH_N PF02737.18 ACS99045.1 - 0.0095 15.8 0.0 0.028 14.3 0.0 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ACS99045.1 - 0.079 13.5 0.1 0.26 11.9 0.1 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Collagen PF01391.18 ACS99046.1 - 0.00011 21.9 85.7 1.8e+04 -15.9 85.7 3.3 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) DUF4179 PF13786.6 ACS99046.1 - 0.12 12.9 6.3 0.87 10.1 6.8 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) TrbI_Ftype PF09677.10 ACS99046.1 - 0.3 11.4 1.9 0.52 10.7 1.9 1.3 1 0 0 1 1 1 0 Type-F conjugative transfer system protein (TrbI_Ftype) Acetyltransf_7 PF13508.7 ACS99047.1 - 3.2e-12 46.7 0.1 4.9e-12 46.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACS99047.1 - 1.5e-11 44.6 0.2 1.8e-11 44.3 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACS99047.1 - 2e-08 34.3 0.0 2.6e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACS99047.1 - 3.9e-06 27.6 0.1 4.6e-06 27.3 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACS99047.1 - 0.00027 21.1 0.0 0.00035 20.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACS99047.1 - 0.013 15.6 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 ACS99047.1 - 0.068 12.6 0.0 0.19 11.2 0.0 1.7 1 1 0 1 1 1 0 Putative acetyl-transferase Sigma70_r4_2 PF08281.12 ACS99049.1 - 1.5e-12 47.0 0.0 3.1e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACS99049.1 - 1.2e-11 44.2 0.4 2.5e-11 43.2 0.2 1.7 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 ACS99049.1 - 6.4e-10 38.4 0.0 1.1e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACS99049.1 - 8.7e-08 32.3 0.8 1.3e-07 31.7 0.8 1.2 1 0 0 1 1 1 1 ECF sigma factor HTH_23 PF13384.6 ACS99049.1 - 0.01 15.6 0.4 0.027 14.3 0.1 1.9 2 0 0 2 2 2 0 Homeodomain-like domain HTH_38 PF13936.6 ACS99049.1 - 0.025 14.3 0.0 0.051 13.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain DUF5643 PF18705.1 ACS99050.1 - 4.5e-20 71.7 10.7 1e-19 70.6 0.6 2.7 2 1 1 3 3 3 2 Family of unknown function (DUF5643) DUF4179 PF13786.6 ACS99050.1 - 6.1e-16 58.7 0.0 1.3e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4179) Abhydrolase_1 PF00561.20 ACS99052.1 - 3.9e-21 75.9 0.2 4.8e-15 55.9 0.2 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ACS99052.1 - 3.7e-14 52.6 0.0 5.2e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ACS99052.1 - 4e-13 50.5 0.7 4.9e-13 50.2 0.7 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 ACS99052.1 - 1.9e-07 30.1 0.0 2.3e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Ndr family Esterase_phd PF10503.9 ACS99052.1 - 0.078 12.5 0.0 2.5 7.5 0.0 2.1 2 0 0 2 2 2 0 Esterase PHB depolymerase HTH_24 PF13412.6 ACS99053.1 - 1.2e-15 56.7 0.4 1.8e-15 56.2 0.4 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 ACS99053.1 - 2.2e-12 46.6 0.4 3.1e-12 46.1 0.4 1.2 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 ACS99053.1 - 8.5e-11 41.7 0.0 2.2e-10 40.4 0.0 1.7 1 1 0 1 1 1 1 Lrp/AsnC ligand binding domain MarR PF01047.22 ACS99053.1 - 5.8e-08 32.5 0.1 1.3e-07 31.5 0.1 1.6 1 0 0 1 1 1 1 MarR family HTH_5 PF01022.20 ACS99053.1 - 2.2e-06 27.5 0.1 4.4e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 ACS99053.1 - 1.1e-05 25.2 0.0 1.6e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 ACS99053.1 - 3.7e-05 23.7 0.0 6.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Fe_dep_repress PF01325.19 ACS99053.1 - 0.00071 19.7 0.0 0.0022 18.2 0.0 1.7 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain HTH_Crp_2 PF13545.6 ACS99053.1 - 0.0011 19.0 0.1 0.0016 18.4 0.1 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_IclR PF09339.10 ACS99053.1 - 0.019 14.8 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain HxlR PF01638.17 ACS99053.1 - 0.02 14.8 0.1 0.049 13.5 0.1 1.8 2 1 0 2 2 2 0 HxlR-like helix-turn-helix DDRGK PF09756.9 ACS99053.1 - 0.032 13.8 0.0 0.044 13.4 0.0 1.2 1 0 0 1 1 1 0 DDRGK domain HTH_34 PF13601.6 ACS99053.1 - 0.034 14.3 0.1 0.057 13.6 0.1 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_11 PF08279.12 ACS99053.1 - 0.047 13.6 0.1 0.076 13.0 0.1 1.3 1 0 0 1 1 1 0 HTH domain DUF977 PF06163.11 ACS99053.1 - 0.063 13.2 0.0 0.084 12.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) TrmB PF01978.19 ACS99053.1 - 0.07 13.0 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_1 PF00126.27 ACS99053.1 - 0.071 13.1 0.1 0.17 11.9 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_10 PF04967.12 ACS99053.1 - 0.076 12.8 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 HTH DNA binding domain HTH_27 PF13463.6 ACS99053.1 - 0.13 12.8 0.1 0.21 12.1 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain Pyr_redox_2 PF07992.14 ACS99054.1 - 5.9e-24 84.8 0.0 2.5e-22 79.5 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACS99054.1 - 2.5e-08 33.6 0.1 0.0018 17.6 0.0 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ACS99054.1 - 3e-07 29.5 0.1 4.5e-05 22.3 0.0 2.4 2 0 0 2 2 2 2 HI0933-like protein GIDA PF01134.22 ACS99054.1 - 5.6e-07 29.0 0.2 0.0092 15.1 0.1 2.3 1 1 1 2 2 2 2 Glucose inhibited division protein A DAO PF01266.24 ACS99054.1 - 1e-06 28.6 0.1 0.00013 21.7 0.1 3.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ACS99054.1 - 1.2e-05 25.4 0.3 0.098 12.6 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 ACS99054.1 - 6.6e-05 22.2 0.0 0.0028 16.8 0.0 2.3 2 1 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 ACS99054.1 - 0.00029 21.0 0.0 0.00081 19.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ACS99054.1 - 0.0016 17.7 0.1 0.0044 16.3 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 ACS99054.1 - 0.033 13.5 0.0 0.062 12.6 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 ACS99054.1 - 0.048 12.9 0.5 0.09 12.1 0.0 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 ACS99054.1 - 0.053 12.6 0.7 0.21 10.6 0.3 2.0 1 1 0 2 2 2 0 Lycopene cyclase protein K_oxygenase PF13434.6 ACS99054.1 - 0.056 12.6 0.0 2.3 7.3 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 ACS99054.1 - 0.08 12.2 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Thi4 family DUF1188 PF06690.11 ACS99054.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) HCBP_related PF06594.11 ACS99054.1 - 0.16 12.0 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Haemolysin-type calcium binding protein related domain DUF4023 PF13215.6 ACS99055.1 - 2.2e-21 75.5 4.8 2.6e-21 75.3 4.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4023) Cation_efflux PF01545.21 ACS99056.1 - 5.2e-50 170.0 24.5 6.4e-50 169.7 24.5 1.1 1 0 0 1 1 1 1 Cation efflux family CitMHS_2 PF16980.5 ACS99056.1 - 0.00023 19.9 0.0 0.00044 19.0 0.0 1.3 1 0 0 1 1 1 1 Putative citrate transport DUF4271 PF14093.6 ACS99056.1 - 0.69 9.8 5.7 0.19 11.6 2.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4271) Phage_holin_1 PF04531.13 ACS99056.1 - 7.2 7.2 7.1 19 5.9 0.0 3.3 2 1 0 3 3 3 0 Bacteriophage holin bPH_1 PF08000.11 ACS99057.1 - 5.5e-37 126.6 0.9 7.7e-37 126.1 0.9 1.2 1 0 0 1 1 1 1 Bacterial PH domain YvbH_ext PF11724.8 ACS99057.1 - 3.4e-25 88.1 0.8 8.3e-25 86.9 0.8 1.6 1 0 0 1 1 1 1 YvbH-like oligomerisation region MFS_1 PF07690.16 ACS99058.1 - 5.6e-57 193.3 46.4 1e-33 116.8 18.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACS99058.1 - 1.4e-13 50.5 29.8 4.5e-05 22.5 0.3 3.3 2 1 1 3 3 3 3 Sugar (and other) transporter MFS_2 PF13347.6 ACS99058.1 - 4.4e-13 48.6 26.9 1.2e-08 33.9 10.5 2.8 1 1 2 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 ACS99058.1 - 2.2e-05 23.5 9.4 2.2e-05 23.5 9.4 2.4 1 1 1 2 2 2 1 MFS_1 like family MFS_4 PF06779.14 ACS99058.1 - 0.0026 17.1 7.2 0.0026 17.1 7.2 2.1 1 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 ACS99058.1 - 0.0082 14.6 14.8 0.013 13.9 14.8 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector PspC PF04024.12 ACS99058.1 - 4.8 7.1 5.9 5.9 6.8 0.1 3.2 2 1 0 2 2 2 0 PspC domain Abhydrolase_1 PF00561.20 ACS99059.1 - 1.9e-27 96.6 0.0 2.7e-20 73.1 0.1 2.0 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACS99059.1 - 1.2e-20 75.0 0.0 1.4e-20 74.8 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACS99059.1 - 3.5e-20 72.3 0.0 5.9e-20 71.5 0.0 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 ACS99059.1 - 0.0014 18.3 0.0 0.99 8.9 0.0 2.2 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) FSH1 PF03959.13 ACS99059.1 - 0.022 14.4 0.0 1.3 8.6 0.0 2.8 2 1 0 2 2 2 0 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 ACS99059.1 - 0.052 13.7 0.0 0.13 12.4 0.0 1.6 2 0 0 2 2 2 0 TAP-like protein Abhydrolase_2 PF02230.16 ACS99059.1 - 0.11 12.3 0.0 8.6 6.1 0.0 2.6 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase GGDEF PF00990.21 ACS99060.1 - 1.7e-40 138.4 0.0 3e-40 137.6 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain dCache_1 PF02743.18 ACS99060.1 - 5.7e-27 95.1 3.0 5.7e-27 95.1 3.0 1.6 2 0 0 2 2 2 1 Cache domain Cache_3-Cache_2 PF17201.4 ACS99060.1 - 1.4e-06 27.8 2.1 1.8e-06 27.5 0.0 2.1 3 0 0 3 3 3 1 Cache 3/Cache 2 fusion domain sCache_3_2 PF17203.4 ACS99060.1 - 0.0038 17.3 0.0 0.53 10.4 0.0 2.5 2 0 0 2 2 2 1 Single cache domain 3 HAMP PF00672.25 ACS99060.1 - 0.014 15.8 0.0 0.053 13.9 0.0 1.9 2 0 0 2 2 2 0 HAMP domain GGDEF_2 PF17853.1 ACS99060.1 - 0.041 14.1 0.0 0.083 13.1 0.0 1.5 1 0 0 1 1 1 0 GGDEF-like domain FecCD PF01032.18 ACS99061.1 - 6.7e-100 334.1 28.0 8.2e-100 333.8 28.0 1.0 1 0 0 1 1 1 1 FecCD transport family ABC-3 PF00950.17 ACS99061.1 - 7.5e-05 22.4 7.3 7.5e-05 22.4 7.3 1.9 1 1 1 2 2 2 1 ABC 3 transport family ThrE PF06738.12 ACS99061.1 - 0.00093 18.6 3.7 0.00093 18.6 3.7 2.3 3 0 0 3 3 3 1 Putative threonine/serine exporter MgtC PF02308.16 ACS99061.1 - 0.0041 17.5 1.7 0.0041 17.5 1.7 2.6 3 2 0 3 3 3 1 MgtC family FecCD PF01032.18 ACS99062.1 - 3.7e-87 292.2 35.7 4.4e-87 292.0 35.7 1.0 1 0 0 1 1 1 1 FecCD transport family ABC-3 PF00950.17 ACS99062.1 - 0.36 10.3 25.2 0.26 10.8 22.3 2.1 1 1 0 1 1 1 0 ABC 3 transport family Peripla_BP_2 PF01497.18 ACS99063.1 - 5.1e-28 98.2 0.4 6.9e-28 97.8 0.4 1.1 1 0 0 1 1 1 1 Periplasmic binding protein LPAM_2 PF13627.6 ACS99063.1 - 0.019 14.8 2.5 0.034 14.0 2.5 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site YaeQ PF07152.12 ACS99063.1 - 0.072 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 YaeQ protein Lebercilin PF15619.6 ACS99063.1 - 0.14 11.8 0.9 0.25 11.0 0.9 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease HTH_18 PF12833.7 ACS99064.1 - 4.9e-22 78.0 0.4 4.9e-22 78.0 0.4 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99064.1 - 1.3e-19 69.8 0.2 5.3e-11 42.3 0.1 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family BPD_transp_1 PF00528.22 ACS99065.1 - 8e-22 77.9 13.0 8e-22 77.9 13.0 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF4383 PF14325.6 ACS99065.1 - 0.013 15.8 1.4 0.013 15.8 1.4 3.3 2 1 2 4 4 4 0 Domain of unknown function (DUF4383) MULE PF10551.9 ACS99065.1 - 0.11 12.9 0.3 0.21 12.0 0.3 1.5 1 0 0 1 1 1 0 MULE transposase domain BPD_transp_1 PF00528.22 ACS99066.1 - 1.8e-21 76.7 21.1 1.8e-21 76.7 21.1 2.6 1 1 1 3 3 3 2 Binding-protein-dependent transport system inner membrane component His_kinase PF06580.13 ACS99067.1 - 4e-19 68.7 0.0 1.1e-18 67.3 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACS99067.1 - 9.5e-10 38.7 0.0 2.8e-09 37.2 0.0 1.9 2 0 0 2 2 2 1 HAMP domain dCache_1 PF02743.18 ACS99067.1 - 1.7e-08 34.6 5.5 3.7e-08 33.5 5.5 1.5 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACS99067.1 - 5.5e-06 26.9 0.0 1.3e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACS99067.1 - 0.098 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Response_reg PF00072.24 ACS99068.1 - 2.6e-24 85.5 0.1 5.8e-24 84.4 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99068.1 - 3.2e-20 72.2 0.0 9.7e-20 70.6 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99068.1 - 7.8e-18 64.1 0.3 1.7e-10 40.7 0.0 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACS99068.1 - 4.2e-07 30.2 0.0 1.9e-06 28.1 0.0 2.1 2 0 0 2 2 2 1 GGDEF-like domain FleQ PF06490.11 ACS99068.1 - 0.12 12.7 0.0 0.39 11.1 0.0 2.0 2 0 0 2 2 2 0 Flagellar regulatory protein FleQ SBP_bac_8 PF13416.6 ACS99069.1 - 1e-41 143.6 15.0 1e-41 143.6 15.0 1.8 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACS99069.1 - 0.0023 17.7 0.4 0.012 15.3 0.4 2.0 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein Melibiase PF02065.18 ACS99070.1 - 3e-34 118.5 0.0 4.7e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 ACS99070.1 - 3.2e-06 26.9 0.0 6e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 N-terminal domain Melibiase_2 PF16499.5 ACS99070.1 - 6e-05 22.3 0.0 0.00014 21.1 0.0 1.5 1 0 0 1 1 1 1 Alpha galactosidase A Glyco_hydro_97 PF10566.9 ACS99070.1 - 0.046 13.0 0.0 0.11 11.8 0.0 1.6 1 1 0 1 1 1 0 Glycoside hydrolase 97 MTES_1575 PF18741.1 ACS99072.1 - 5.2e-08 32.9 0.0 8.6e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 REase_MTES_1575 HTH_11 PF08279.12 ACS99072.1 - 0.00049 20.0 0.0 0.00084 19.2 0.0 1.3 1 0 0 1 1 1 1 HTH domain FaeA PF04703.12 ACS99072.1 - 0.00049 20.4 0.0 0.00092 19.5 0.0 1.4 1 0 0 1 1 1 1 FaeA-like protein DUF559 PF04480.12 ACS99072.1 - 0.00072 19.4 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF559) HTH_DeoR PF08220.12 ACS99072.1 - 0.0018 17.9 0.0 0.0038 16.9 0.0 1.5 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain RAP PF08373.10 ACS99072.1 - 0.0087 16.1 0.7 0.022 14.8 0.0 2.0 3 0 0 3 3 3 1 RAP domain GntR PF00392.21 ACS99072.1 - 0.034 13.8 0.0 0.063 12.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_10 PF04967.12 ACS99072.1 - 0.06 13.2 0.0 0.35 10.7 0.0 2.1 1 1 0 1 1 1 0 HTH DNA binding domain PaaX PF07848.12 ACS99072.1 - 0.069 13.4 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 PaaX-like protein HTH_24 PF13412.6 ACS99072.1 - 0.084 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Ribosomal_S25 PF03297.15 ACS99072.1 - 0.096 12.9 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 S25 ribosomal protein MarR_2 PF12802.7 ACS99072.1 - 0.14 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 MarR family DUF2847 PF11009.8 ACS99073.1 - 6.1e-36 122.5 0.2 6.8e-36 122.3 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2847) LytTR PF04397.15 ACS99073.1 - 0.047 13.9 0.0 0.082 13.1 0.0 1.5 1 0 0 1 1 1 0 LytTr DNA-binding domain T4_deiodinase PF00837.17 ACS99073.1 - 0.049 12.9 0.0 0.055 12.8 0.0 1.1 1 0 0 1 1 1 0 Iodothyronine deiodinase ABC_tran PF00005.27 ACS99074.1 - 3e-35 121.7 0.0 5.4e-35 120.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS99074.1 - 9.8e-11 42.0 0.9 4.3e-06 26.8 0.1 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system TOBE_2 PF08402.10 ACS99074.1 - 9.1e-09 35.4 0.0 2e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 TOBE domain AAA PF00004.29 ACS99074.1 - 6.9e-05 23.3 0.5 0.0015 18.9 0.5 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ACS99074.1 - 0.00026 21.3 0.3 0.0011 19.3 0.3 1.9 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 ACS99074.1 - 0.0011 19.0 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_25 PF13481.6 ACS99074.1 - 0.0014 18.3 0.0 0.94 9.0 0.0 2.5 2 1 0 2 2 2 2 AAA domain SMC_N PF02463.19 ACS99074.1 - 0.0024 17.3 0.1 0.099 12.1 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACS99074.1 - 0.0035 17.7 0.0 0.0064 16.9 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 ACS99074.1 - 0.0047 17.2 0.6 2 8.6 0.1 2.6 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ACS99074.1 - 0.0078 16.1 0.0 0.026 14.4 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 ACS99074.1 - 0.0083 15.9 0.0 0.028 14.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ACS99074.1 - 0.0085 16.1 0.1 0.11 12.5 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ACS99074.1 - 0.0088 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACS99074.1 - 0.015 15.8 0.1 0.043 14.3 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ACS99074.1 - 0.02 14.7 0.0 0.041 13.6 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 ACS99074.1 - 0.034 14.2 0.1 0.21 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ACS99074.1 - 0.043 13.7 0.1 0.093 12.6 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Adeno_IVa2 PF02456.15 ACS99074.1 - 0.17 10.6 0.0 0.27 10.0 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein BPD_transp_1 PF00528.22 ACS99075.1 - 4.2e-09 36.4 23.4 4.2e-09 36.4 23.4 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99076.1 - 3.1e-16 59.7 17.7 3.1e-16 59.7 17.7 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Orf78 PF06024.12 ACS99076.1 - 0.88 9.9 0.1 0.88 9.9 0.1 3.2 4 0 0 4 4 4 0 Orf78 (ac78) DUF3483 PF11982.8 ACS99076.1 - 1.8 8.1 6.8 11 5.6 0.0 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF3483) SBP_bac_8 PF13416.6 ACS99077.1 - 2.8e-39 135.6 0.7 3.4e-39 135.3 0.7 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACS99077.1 - 5.7e-32 111.1 0.3 7.5e-32 110.7 0.3 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACS99077.1 - 1.5e-23 84.2 3.2 5.7e-23 82.4 3.2 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACS99077.1 - 1e-15 58.1 0.0 1.5e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Lipoprotein_8 PF02030.15 ACS99077.1 - 1.3e-08 34.0 0.1 4.5e-08 32.3 0.0 1.9 2 0 0 2 2 2 1 Hypothetical lipoprotein (MG045 family) ABC2_membrane_3 PF12698.7 ACS99077.1 - 0.0079 15.3 2.1 0.0086 15.2 2.0 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein NTNH_C PF08470.10 ACS99077.1 - 0.047 13.6 0.0 0.096 12.6 0.0 1.6 1 0 0 1 1 1 0 Nontoxic nonhaemagglutinin C-terminal SLH PF00395.20 ACS99078.1 - 5.1e-34 116.0 10.4 2.7e-13 49.7 0.5 3.7 3 0 0 3 3 3 3 S-layer homology domain DUF748 PF05359.11 ACS99078.1 - 0.074 13.2 3.5 0.56 10.4 0.1 3.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF748) Wzz PF02706.15 ACS99079.1 - 3.4e-18 65.7 0.5 3.4e-18 65.7 0.5 2.7 3 0 0 3 3 3 1 Chain length determinant protein GNVR PF13807.6 ACS99079.1 - 2.8e-06 27.1 0.5 2.8e-06 27.1 0.5 2.8 2 1 1 3 3 3 1 G-rich domain on putative tyrosine kinase Nuc_H_symport PF03825.16 ACS99079.1 - 0.021 13.8 2.2 0.24 10.3 0.1 2.2 1 1 0 2 2 2 0 Nucleoside H+ symporter TatC PF00902.18 ACS99079.1 - 0.022 14.6 5.1 0.096 12.5 5.1 1.8 1 1 0 1 1 1 0 Sec-independent protein translocase protein (TatC) Sigma_reg_N PF13800.6 ACS99079.1 - 1.3 9.3 6.7 3.6 8.0 0.4 3.1 3 0 0 3 3 3 0 Sigma factor regulator N-terminal AAA_31 PF13614.6 ACS99080.1 - 1e-16 61.3 1.4 2.3e-16 60.2 1.4 1.5 1 1 0 1 1 1 1 AAA domain ParA PF10609.9 ACS99080.1 - 1.3e-14 54.3 2.6 2e-14 53.6 2.6 1.3 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ACS99080.1 - 1.8e-11 44.2 0.4 3.3e-11 43.3 0.4 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 ACS99080.1 - 7.1e-09 35.3 0.2 1e-08 34.8 0.2 1.2 1 0 0 1 1 1 1 ATPase MipZ SRP54 PF00448.22 ACS99080.1 - 1.6e-05 24.6 1.2 0.00026 20.7 1.2 2.4 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 ACS99080.1 - 0.00024 20.7 0.1 0.00034 20.2 0.1 1.3 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ AAA_26 PF13500.6 ACS99080.1 - 0.0011 18.9 4.0 0.019 14.8 4.0 2.3 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 ACS99080.1 - 0.0036 16.8 0.5 0.0089 15.5 0.0 1.9 3 0 0 3 3 3 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CLP1_P PF16575.5 ACS99080.1 - 0.0071 16.2 1.2 0.04 13.7 1.2 2.1 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 ACS99080.1 - 0.011 15.8 1.0 0.071 13.2 1.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase ArsA_ATPase PF02374.15 ACS99080.1 - 0.011 14.9 3.6 0.072 12.3 0.1 2.7 1 1 1 3 3 3 0 Anion-transporting ATPase KTI12 PF08433.10 ACS99080.1 - 0.023 14.1 0.3 0.14 11.6 0.0 2.1 1 1 0 2 2 2 0 Chromatin associated protein KTI12 NTPase_1 PF03266.15 ACS99080.1 - 0.035 14.0 0.0 3.3 7.6 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_30 PF13604.6 ACS99080.1 - 0.037 13.8 0.5 0.075 12.7 0.5 1.7 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ACS99080.1 - 0.073 13.4 0.4 0.14 12.4 0.4 1.8 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ACS99080.1 - 0.074 12.3 0.1 0.17 11.1 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin MeaB PF03308.16 ACS99080.1 - 0.076 12.0 0.2 0.15 11.0 0.0 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB VirC1 PF07015.11 ACS99080.1 - 0.083 12.2 0.0 0.21 10.9 0.0 1.7 1 1 1 2 2 2 0 VirC1 protein NTP_transferase PF00483.23 ACS99081.1 - 1.3e-34 119.9 0.0 1.6e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACS99081.1 - 6.9e-09 36.3 0.0 9.4e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 ACS99081.1 - 0.008 15.9 0.0 0.021 14.6 0.0 1.6 2 0 0 2 2 2 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Glycos_transf_2 PF00535.26 ACS99081.1 - 0.032 14.0 0.0 0.052 13.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 Smr PF01713.21 ACS99081.1 - 0.089 13.2 0.0 0.78 10.1 0.0 2.3 2 0 0 2 2 2 0 Smr domain Bac_transf PF02397.16 ACS99082.1 - 1.2e-70 236.9 0.1 1.4e-70 236.7 0.1 1.1 1 0 0 1 1 1 1 Bacterial sugar transferase Epimerase PF01370.21 ACS99083.1 - 2e-81 273.0 0.0 2.4e-81 272.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACS99083.1 - 6.7e-20 71.7 0.0 5.3e-18 65.5 0.0 2.7 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ACS99083.1 - 1.4e-06 27.7 0.0 8.5e-06 25.1 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ACS99083.1 - 5.5e-05 22.4 0.0 7.3e-05 22.0 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain Abhydrolase_5 PF12695.7 ACS99083.1 - 0.023 14.5 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family NAD_binding_10 PF13460.6 ACS99083.1 - 0.027 14.4 0.0 0.065 13.1 0.0 1.7 1 1 0 1 1 1 0 NAD(P)H-binding NmrA PF05368.13 ACS99083.1 - 0.066 12.8 0.2 3.4 7.2 0.1 2.7 2 1 0 2 2 2 0 NmrA-like family GDP_Man_Dehyd PF16363.5 ACS99084.1 - 6.3e-152 505.7 0.0 7.2e-152 505.5 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ACS99084.1 - 3e-74 249.5 0.0 3.9e-74 249.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ACS99084.1 - 5.8e-08 32.2 0.0 1.3e-07 31.0 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ACS99084.1 - 9.2e-06 25.0 0.0 2e-05 23.9 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ACS99084.1 - 0.00035 19.8 0.0 0.00049 19.4 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NmrA PF05368.13 ACS99084.1 - 0.0088 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 ACS99084.1 - 0.079 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 KR domain Tricorn_PDZ PF14685.6 ACS99084.1 - 0.12 12.3 0.0 7.3 6.6 0.0 2.6 2 0 0 2 2 2 0 Tricorn protease PDZ domain Gas_vesicle_C PF01304.17 ACS99084.1 - 0.17 11.9 2.0 1.3 9.1 0.8 2.4 2 0 0 2 2 2 0 Gas vesicles protein GVPc repeated domain Glycos_transf_1 PF00534.20 ACS99085.1 - 2.5e-11 43.4 0.3 6.9e-11 42.0 0.2 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ACS99085.1 - 1.5e-05 25.5 0.0 2.2e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 ACS99085.1 - 0.024 14.7 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 RNA_polI_A14 PF08203.11 ACS99085.1 - 0.055 14.2 0.1 0.48 11.2 0.0 2.3 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 CopG_antitoxin PF12441.8 ACS99085.1 - 0.13 12.8 0.1 0.66 10.6 0.0 2.3 3 0 0 3 3 3 0 CopG antitoxin of type II toxin-antitoxin system Hexapep PF00132.24 ACS99086.1 - 6e-13 48.0 18.5 8.5e-10 38.0 4.2 4.4 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACS99086.1 - 5.6e-11 42.0 20.8 2e-09 37.0 5.4 4.4 4 0 0 4 4 4 3 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 ACS99086.1 - 0.023 13.7 0.3 0.25 10.3 0.0 2.0 2 0 0 2 2 2 0 L-fucokinase Glycos_transf_1 PF00534.20 ACS99087.1 - 7.1e-21 74.5 0.4 1.2e-20 73.7 0.4 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99087.1 - 7.4e-15 55.6 0.0 1.5e-14 54.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ACS99087.1 - 4.6e-05 23.7 0.0 8.8e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACS99087.1 - 0.00035 20.6 0.0 0.0021 18.1 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_transf_18 PF15024.6 ACS99087.1 - 0.00042 19.1 0.0 0.00061 18.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 18 RPN6_C_helix PF18503.1 ACS99087.1 - 0.12 12.2 0.3 1.7 8.5 0.0 2.4 2 0 0 2 2 2 0 26S proteasome subunit RPN6 C-terminal helix domain Glycos_transf_2 PF00535.26 ACS99088.1 - 2.7e-29 102.2 0.1 4.6e-29 101.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 ACS99088.1 - 4e-19 69.1 0.1 5.6e-19 68.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 ACS99088.1 - 1.8e-18 67.3 0.0 2.4e-18 66.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ACS99088.1 - 1.9e-05 24.7 0.0 3.2e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 ACS99088.1 - 0.022 14.2 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 21 SLC3A2_N PF16028.5 ACS99089.1 - 0.085 12.4 2.9 0.31 10.6 0.6 2.8 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus UPF0016 PF01169.19 ACS99089.1 - 0.96 9.8 6.5 3.6 8.0 0.2 3.4 3 1 0 3 3 3 0 Uncharacterized protein family UPF0016 NTP_transferase PF00483.23 ACS99090.1 - 2e-29 102.9 0.0 2.9e-29 102.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase MannoseP_isomer PF01050.18 ACS99090.1 - 1.1e-11 44.8 0.3 3.5e-11 43.2 0.3 1.8 1 1 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.11 ACS99090.1 - 4.7e-06 26.2 0.0 9.4e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ACS99090.1 - 0.038 13.6 0.0 0.079 12.6 0.0 1.4 1 0 0 1 1 1 0 Cupin NTP_transf_3 PF12804.7 ACS99090.1 - 0.045 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 MobA-like NTP transferase domain Polysacc_synt PF01943.17 ACS99091.1 - 1.6e-26 93.3 27.4 1.6e-26 93.3 27.4 3.0 2 1 1 3 3 3 2 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.6 ACS99091.1 - 1.9e-21 76.6 17.8 1.9e-21 76.6 17.8 3.5 2 1 1 3 3 3 1 Polysaccharide biosynthesis C-terminal domain MurJ PF03023.14 ACS99091.1 - 1e-08 34.3 28.4 1e-08 34.3 28.4 2.7 2 1 0 2 2 2 1 Lipid II flippase MurJ ATPgrasp_TupA PF14305.6 ACS99092.1 - 5e-60 203.3 1.6 6.1e-60 203.0 1.6 1.1 1 0 0 1 1 1 1 TupA-like ATPgrasp Glyco_trans_1_3 PF13528.6 ACS99093.1 - 3.9e-09 36.2 0.0 4.6e-06 26.1 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.16 ACS99093.1 - 0.00026 21.0 0.0 0.00044 20.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPG_MGDP_dh_N PF03721.14 ACS99094.1 - 3.8e-63 212.5 0.5 6.2e-63 211.8 0.5 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 ACS99094.1 - 6.6e-41 138.4 0.1 1.2e-40 137.6 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 ACS99094.1 - 6e-34 116.6 0.0 3e-30 104.7 0.0 2.7 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain F420_oxidored PF03807.17 ACS99094.1 - 1.1e-05 25.9 0.9 1.2 9.8 0.1 4.0 3 1 0 3 3 3 2 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.27 ACS99094.1 - 0.00096 19.7 0.6 0.024 15.2 0.2 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 ACS99094.1 - 0.0032 17.6 0.0 1.1 9.5 0.1 2.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 ACS99094.1 - 0.0037 17.2 0.1 0.012 15.5 0.1 1.9 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 ACS99094.1 - 0.0038 17.2 0.1 0.011 15.7 0.1 1.9 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 ACS99094.1 - 0.0052 16.5 0.1 0.021 14.5 0.1 1.9 1 1 0 2 2 2 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 ACS99094.1 - 0.025 14.0 1.4 5.7 6.3 0.0 4.0 4 1 1 5 5 5 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF2160 PF09928.9 ACS99095.1 - 0.0097 16.2 1.2 0.016 15.5 1.2 1.3 1 0 0 1 1 1 1 Predicted small integral membrane protein (DUF2160) UPF0137 PF03677.13 ACS99095.1 - 0.035 13.9 0.6 8.2 6.1 0.1 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0137) MAP17 PF15807.5 ACS99095.1 - 0.038 14.2 2.3 0.096 12.9 0.0 2.3 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Cu_amine_oxidN1 PF07833.11 ACS99096.1 - 4.7e-28 97.5 1.0 9e-20 71.0 0.1 2.1 1 1 1 2 2 2 2 Copper amine oxidase N-terminal domain Herpes_capsid PF06112.11 ACS99096.1 - 0.59 10.2 8.0 1.3 9.1 8.0 1.6 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein VanZ PF04892.12 ACS99098.1 - 1.3e-15 58.1 2.3 1.8e-15 57.7 2.3 1.1 1 0 0 1 1 1 1 VanZ like family SDF PF00375.18 ACS99098.1 - 0.062 12.3 0.2 0.062 12.3 0.2 1.5 2 0 0 2 2 2 0 Sodium:dicarboxylate symporter family DUF5504 PF17608.2 ACS99098.1 - 0.072 13.2 3.8 2.6 8.1 0.1 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5504) 7TMR-DISM_7TM PF07695.11 ACS99098.1 - 0.079 12.8 6.1 1.5 8.7 0.1 2.3 2 1 0 2 2 2 0 7TM diverse intracellular signalling Wzy_C PF04932.15 ACS99098.1 - 4.8 6.8 6.8 13 5.3 1.9 2.5 2 1 0 3 3 3 0 O-Antigen ligase NAPRTase_N PF17767.1 ACS99099.1 - 4.8e-39 133.6 0.0 2.6e-38 131.2 0.0 2.1 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase_C PF17956.1 ACS99099.1 - 1.7e-29 102.5 0.1 2.5e-29 101.9 0.1 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 ACS99099.1 - 1.6e-10 41.0 0.0 2.4e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family QRPTase_N PF02749.16 ACS99099.1 - 0.1 12.6 0.0 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain HTH_18 PF12833.7 ACS99100.1 - 2e-17 63.2 0.1 7.9e-17 61.3 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99100.1 - 4.8e-14 52.0 0.1 2.7e-10 40.0 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99100.1 - 0.00012 22.0 0.5 0.00022 21.1 0.3 1.6 1 1 0 1 1 1 1 AraC-like ligand binding domain MatE PF01554.18 ACS99102.1 - 1.3e-51 174.5 39.0 5.1e-30 104.3 12.6 2.4 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ACS99102.1 - 4.5e-05 23.5 8.8 4.5e-05 23.5 8.8 4.6 3 1 2 5 5 5 1 Polysaccharide biosynthesis C-terminal domain TFIID_NTD2 PF04494.15 ACS99102.1 - 0.12 12.6 0.1 0.25 11.6 0.1 1.5 1 0 0 1 1 1 0 WD40 associated region in TFIID subunit, NTD2 domain CaKB PF03185.15 ACS99102.1 - 0.15 11.7 0.1 0.57 9.8 0.1 2.0 1 0 0 1 1 1 0 Calcium-activated potassium channel, beta subunit IF3_N PF05198.16 ACS99103.1 - 3.5e-16 59.2 0.2 1.1e-15 57.7 0.1 1.8 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain IF3_C PF00707.22 ACS99103.1 - 5.1e-15 55.2 0.0 8.5e-15 54.5 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain ABC_membrane PF00664.23 ACS99104.1 - 2.9e-53 181.3 14.0 3.7e-53 180.9 14.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACS99104.1 - 1.4e-35 122.8 0.0 2.9e-35 121.8 0.0 1.6 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 ACS99104.1 - 4.7e-10 39.3 0.0 4e-09 36.2 0.0 1.8 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACS99104.1 - 0.00022 21.7 0.2 0.00051 20.5 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ACS99104.1 - 0.00055 19.9 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA PF00004.29 ACS99104.1 - 0.00088 19.7 0.2 0.011 16.1 0.2 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ACS99104.1 - 0.0022 17.7 0.0 0.0038 17.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACS99104.1 - 0.0062 16.8 0.1 0.13 12.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ACS99104.1 - 0.035 14.6 0.0 0.071 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ACS99104.1 - 0.057 13.1 0.1 0.49 10.1 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein DEAD PF00270.29 ACS99104.1 - 0.063 13.0 0.1 0.32 10.7 0.1 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_29 PF13555.6 ACS99104.1 - 0.082 12.7 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 ACS99104.1 - 0.088 12.5 0.1 0.44 10.2 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ACS99104.1 - 0.088 12.4 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 ACS99104.1 - 0.14 9.6 0.0 0.22 9.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_33 PF13671.6 ACS99104.1 - 0.16 12.1 0.0 0.45 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ACS99104.1 - 0.19 12.0 0.2 0.68 10.2 0.1 2.0 1 1 1 2 2 2 0 AAA domain ABC_membrane_3 PF13748.6 ACS99104.1 - 0.58 9.3 7.6 0.4 9.9 0.8 2.3 2 0 0 2 2 2 0 ABC transporter transmembrane region UbiA PF01040.18 ACS99105.1 - 4.8e-24 85.0 17.0 8.2e-24 84.3 17.0 1.4 1 1 0 1 1 1 1 UbiA prenyltransferase family Ceramidase PF05875.12 ACS99105.1 - 0.018 14.4 0.8 0.018 14.4 0.8 2.5 2 1 0 2 2 2 0 Ceramidase DUF4231 PF14015.6 ACS99105.1 - 0.13 12.8 0.0 0.13 12.8 0.0 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF4231) EamA PF00892.20 ACS99106.1 - 8.9e-09 35.6 13.5 2.1e-08 34.5 13.5 1.5 1 1 0 1 1 1 1 EamA-like transporter family Multi_Drug_Res PF00893.19 ACS99106.1 - 1.6e-06 28.7 8.4 2.7e-06 28.0 8.4 1.3 1 1 0 1 1 1 1 Small Multidrug Resistance protein TMEM234 PF10639.9 ACS99106.1 - 0.0037 17.3 1.8 0.0045 17.0 1.1 1.5 1 1 1 2 2 2 1 Putative transmembrane family 234 DUF202 PF02656.15 ACS99106.1 - 0.37 11.3 8.8 72 3.9 8.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF212 PF02681.14 ACS99107.1 - 5.4e-35 120.3 0.2 6.5e-35 120.0 0.2 1.0 1 0 0 1 1 1 1 Divergent PAP2 family Xan_ur_permease PF00860.20 ACS99107.1 - 0.00055 18.8 0.4 0.00055 18.8 0.4 1.4 1 1 1 2 2 2 1 Permease family PAP2 PF01569.21 ACS99107.1 - 0.0084 15.9 6.2 0.13 12.1 0.3 2.5 2 1 0 2 2 2 2 PAP2 superfamily PHO4 PF01384.20 ACS99107.1 - 0.05 12.6 2.4 0.17 10.9 2.4 1.8 1 1 0 1 1 1 0 Phosphate transporter family Sid-5 PF17204.3 ACS99108.1 - 0.038 14.2 7.9 0.92 9.7 0.1 4.1 3 0 0 3 3 3 0 Sid-5 family CbiN PF02553.15 ACS99109.1 - 2 8.5 5.2 3.9 7.5 0.1 3.8 3 0 0 3 3 3 0 Cobalt transport protein component CbiN DUF2518 PF10726.9 ACS99109.1 - 3.3 7.3 8.9 5.2 6.7 1.0 2.8 2 0 0 2 2 2 0 Protein of function (DUF2518) DUF4131 PF13567.6 ACS99109.1 - 5.5 6.6 31.9 0.77 9.4 0.8 4.9 4 1 0 4 4 4 0 Domain of unknown function (DUF4131) His_kinase PF06580.13 ACS99110.1 - 1.1e-22 80.2 0.7 1.1e-22 80.2 0.7 1.9 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACS99110.1 - 4.3e-13 49.8 0.1 1.1e-12 48.4 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACS99110.1 - 6.3e-05 22.9 1.5 6.3e-05 22.9 1.5 1.8 2 0 0 2 2 2 1 Cache domain HATPase_c_2 PF13581.6 ACS99110.1 - 0.00049 20.1 0.0 0.0011 19.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 ACS99110.1 - 0.0025 17.7 0.6 0.01 15.7 0.1 2.3 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 ACS99110.1 - 0.0084 15.9 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase bPH_5 PF10882.8 ACS99110.1 - 0.045 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial PH domain WW PF00397.26 ACS99110.1 - 0.13 12.4 2.6 1.9 8.6 0.3 2.5 2 0 0 2 2 2 0 WW domain DUF4795 PF16043.5 ACS99110.1 - 4.7 6.8 7.4 12 5.4 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) Response_reg PF00072.24 ACS99111.1 - 7e-24 84.2 0.2 1.3e-23 83.3 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99111.1 - 9.4e-21 73.9 0.0 1.9e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99111.1 - 5.8e-13 48.6 0.2 3.8e-05 23.7 0.1 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family UPF0122 PF04297.14 ACS99111.1 - 0.034 14.4 0.4 0.12 12.6 0.4 2.0 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like Kinesin_assoc PF16183.5 ACS99111.1 - 0.096 12.8 0.5 3.9 7.6 0.1 2.4 2 0 0 2 2 2 0 Kinesin-associated SBP_bac_1 PF01547.25 ACS99112.1 - 4.6e-11 43.2 12.1 4.6e-11 43.2 12.1 2.0 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein LPAM_1 PF08139.12 ACS99112.1 - 0.69 10.5 5.0 1.4 9.6 5.0 1.5 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site BPD_transp_1 PF00528.22 ACS99113.1 - 4.3e-13 49.4 13.0 4.3e-13 49.4 13.0 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99114.1 - 1.1e-15 57.9 13.7 1.1e-15 57.9 13.7 1.9 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component FA_desaturase PF00487.24 ACS99114.1 - 7.2 6.4 11.1 1.1 9.0 4.4 2.4 2 1 0 3 3 3 0 Fatty acid desaturase Glyco_hydro_43 PF04616.14 ACS99115.1 - 6.7e-64 216.0 2.8 7.6e-64 215.8 2.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_130 PF04041.13 ACS99115.1 - 0.0093 14.9 0.1 1.2 8.1 0.0 2.4 2 1 0 2 2 2 2 beta-1,4-mannooligosaccharide phosphorylase Cupin_5 PF06172.11 ACS99116.1 - 2.5e-43 147.6 0.0 2.9e-43 147.4 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily (DUF985) MFS_1 PF07690.16 ACS99117.1 - 2e-51 175.0 59.4 1.8e-36 125.8 30.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACS99117.1 - 1.5e-11 43.9 37.9 8.4e-11 41.4 12.9 2.5 1 1 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 ACS99117.1 - 6.3e-11 41.7 28.1 5.8e-07 28.7 14.8 2.2 1 1 1 2 2 2 2 MFS_1 like family MFS_2 PF13347.6 ACS99117.1 - 1.2e-08 34.0 11.3 1.2e-08 34.0 11.3 2.4 1 1 1 2 2 2 1 MFS/sugar transport protein MFS_3 PF05977.13 ACS99117.1 - 0.00011 20.7 20.6 0.00011 20.7 20.6 2.0 1 1 1 2 2 2 2 Transmembrane secretion effector MFS_4 PF06779.14 ACS99117.1 - 0.0029 16.9 28.3 0.005 16.2 28.3 1.4 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Trp_oprn_chp PF09534.10 ACS99117.1 - 0.085 12.7 9.3 0.059 13.2 0.7 2.6 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PUCC PF03209.15 ACS99117.1 - 0.16 10.9 27.8 0.024 13.7 4.7 2.5 2 1 0 2 2 2 0 PUCC protein 5_nucleotid_C PF02872.18 ACS99118.1 - 9.3e-53 178.7 0.2 1.7e-52 177.8 0.2 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain LysM PF01476.20 ACS99118.1 - 4.2e-20 71.5 1.1 9.2e-20 70.4 1.1 1.6 1 0 0 1 1 1 1 LysM domain Metallophos PF00149.28 ACS99118.1 - 1.1e-12 48.9 0.1 1.8e-12 48.2 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Trypan_PARP PF05887.11 ACS99118.1 - 5.5e-06 26.4 10.6 5.5e-06 26.4 10.6 2.9 3 0 0 3 3 3 1 Procyclic acidic repetitive protein (PARP) TonB_N PF16031.5 ACS99118.1 - 0.00031 21.3 20.7 0.00083 19.9 20.7 1.7 1 0 0 1 1 1 1 TonB polyproline region HRDC PF00570.23 ACS99118.1 - 0.0051 16.8 0.1 0.26 11.3 0.0 2.3 2 0 0 2 2 2 1 HRDC domain Metallophos_2 PF12850.7 ACS99118.1 - 0.02 15.1 0.1 0.083 13.1 0.1 2.0 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain YjbT PF17089.5 ACS99118.1 - 0.16 12.0 2.0 1.1 9.3 0.2 2.4 2 0 0 2 2 2 0 Uncharacterised protein family DUF2868 PF11067.8 ACS99118.1 - 0.26 10.8 0.5 0.55 9.7 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Sugar-bind PF04198.13 ACS99119.1 - 1.7e-72 243.7 0.2 2e-72 243.4 0.2 1.1 1 0 0 1 1 1 1 Putative sugar-binding domain HTH_Crp_2 PF13545.6 ACS99119.1 - 3.6e-08 33.2 0.0 9.2e-08 32.0 0.0 1.7 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_23 PF13384.6 ACS99119.1 - 1.4e-07 31.1 0.5 3.2e-07 29.9 0.0 1.9 2 0 0 2 2 1 1 Homeodomain-like domain HTH_24 PF13412.6 ACS99119.1 - 1.1e-06 28.1 0.0 3.2e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Sigma70_r4_2 PF08281.12 ACS99119.1 - 8.1e-06 25.4 0.1 1.9e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 DeoRC PF00455.22 ACS99119.1 - 1.8e-05 24.8 0.1 0.00014 21.8 0.1 2.5 2 1 0 2 2 2 1 DeoR C terminal sensor domain Sigma70_r4 PF04545.16 ACS99119.1 - 1.8e-05 24.1 0.1 7.4e-05 22.2 0.1 2.1 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_29 PF13551.6 ACS99119.1 - 1.8e-05 24.6 0.0 3.8e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_3 PF01381.22 ACS99119.1 - 3.5e-05 23.8 0.1 0.00015 21.7 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix MarR_2 PF12802.7 ACS99119.1 - 4.8e-05 23.2 0.0 9.8e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_28 PF13518.6 ACS99119.1 - 5.6e-05 23.2 0.0 0.00015 21.8 0.0 1.8 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 ACS99119.1 - 0.00017 21.2 0.0 0.00073 19.2 0.0 2.1 3 0 0 3 3 1 1 Helix-turn-helix domain TrmB PF01978.19 ACS99119.1 - 0.00023 21.0 0.0 0.0072 16.2 0.0 2.7 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB GntR PF00392.21 ACS99119.1 - 0.00032 20.3 0.0 0.00075 19.1 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family LacI PF00356.21 ACS99119.1 - 0.00044 20.0 0.0 0.0023 17.7 0.0 2.2 2 0 0 2 2 1 1 Bacterial regulatory proteins, lacI family DUF134 PF02001.16 ACS99119.1 - 0.00055 20.4 0.1 0.0016 19.0 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function DUF134 HTH_5 PF01022.20 ACS99119.1 - 0.00059 19.6 0.0 0.0027 17.6 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.12 ACS99119.1 - 0.0011 18.9 0.0 0.0033 17.3 0.0 1.8 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 ACS99119.1 - 0.0016 18.3 0.0 0.0033 17.3 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_10 PF04967.12 ACS99119.1 - 0.0021 17.9 0.0 0.006 16.4 0.0 1.8 1 0 0 1 1 1 1 HTH DNA binding domain HTH_30 PF13556.6 ACS99119.1 - 0.0041 16.9 0.0 0.0079 16.0 0.0 1.4 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_37 PF13744.6 ACS99119.1 - 0.0042 17.0 0.1 0.01 15.7 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_IclR PF09339.10 ACS99119.1 - 0.0043 16.8 0.0 0.0091 15.8 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain Terminase_5 PF06056.12 ACS99119.1 - 0.005 16.7 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) Crp PF00325.20 ACS99119.1 - 0.0069 16.0 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, crp family Fe_dep_repress PF01325.19 ACS99119.1 - 0.011 15.9 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain UPF0122 PF04297.14 ACS99119.1 - 0.014 15.6 0.1 0.031 14.5 0.1 1.6 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like HTH_40 PF14493.6 ACS99119.1 - 0.017 15.6 0.0 0.054 14.0 0.0 2.0 2 0 0 2 2 1 0 Helix-turn-helix domain HTH_8 PF02954.19 ACS99119.1 - 0.02 14.7 0.0 0.05 13.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family YdaS_antitoxin PF15943.5 ACS99119.1 - 0.024 14.5 0.0 0.06 13.2 0.0 1.6 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Sigma70_ECF PF07638.11 ACS99119.1 - 0.026 14.4 0.0 0.064 13.1 0.0 1.6 2 0 0 2 2 2 0 ECF sigma factor HTH_36 PF13730.6 ACS99119.1 - 0.027 14.4 0.0 0.16 11.9 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Phage_NinH PF06322.11 ACS99119.1 - 0.03 14.2 0.0 0.083 12.8 0.0 1.8 1 0 0 1 1 1 0 Phage NinH protein HTH_22 PF13309.6 ACS99119.1 - 0.043 13.9 0.0 0.17 12.0 0.0 2.0 1 0 0 1 1 1 0 HTH domain HTH_Tnp_1_2 PF13022.6 ACS99119.1 - 0.051 13.7 0.1 0.1 12.7 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase HTH_17 PF12728.7 ACS99119.1 - 0.055 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_AsnC-type PF13404.6 ACS99119.1 - 0.078 12.8 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_6 PF01418.17 ACS99119.1 - 0.081 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family Phage_antitermQ PF06530.12 ACS99119.1 - 0.1 12.5 0.2 0.26 11.2 0.2 1.7 1 0 0 1 1 1 0 Phage antitermination protein Q DeoC PF01791.9 ACS99120.1 - 1.1e-23 84.1 6.8 1.3e-23 83.8 6.8 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase ComA PF02679.15 ACS99120.1 - 0.013 15.0 0.2 0.59 9.5 0.0 2.2 2 1 0 2 2 2 0 (2R)-phospho-3-sulfolactate synthase (ComA) KDGP_aldolase PF07071.11 ACS99120.1 - 0.023 14.5 0.4 0.058 13.2 0.4 1.7 1 1 1 2 2 2 0 KDGP aldolase Sulfate_transp PF00916.20 ACS99121.1 - 6.7e-58 196.3 31.5 3.8e-33 114.8 6.3 2.2 1 1 1 2 2 2 2 Sulfate permease family STAS PF01740.21 ACS99121.1 - 3.1e-06 26.8 0.0 5.4e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ACS99121.1 - 6.2e-05 23.4 35.5 0.00012 22.4 4.0 4.0 4 0 0 4 4 4 3 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 ACS99121.1 - 0.0069 16.7 0.1 0.014 15.8 0.1 1.5 1 0 0 1 1 1 1 STAS domain Ldr_toxin PF13940.6 ACS99121.1 - 1.9 8.6 4.5 4 7.6 0.2 3.3 3 0 0 3 3 3 0 Toxin Ldr, type I toxin-antitoxin system DarT PF14487.6 ACS99122.1 - 0.004 17.0 0.1 0.068 13.0 0.1 2.1 1 1 0 1 1 1 1 ssDNA thymidine ADP-ribosyltransferase, DarT Aldose_epim PF01263.20 ACS99123.1 - 1.2e-22 80.6 0.1 1.9e-22 80.0 0.1 1.3 1 1 0 1 1 1 1 Aldose 1-epimerase Glyco_hydro_79C PF16862.5 ACS99123.1 - 0.078 13.9 0.2 0.17 12.8 0.2 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 79 C-terminal beta domain Rotamase_3 PF13616.6 ACS99124.1 - 2.3e-28 99.0 0.6 2.3e-28 99.0 0.6 2.6 1 1 0 2 2 2 1 PPIC-type PPIASE domain Rotamase PF00639.21 ACS99124.1 - 1.8e-25 89.7 0.2 1.8e-25 89.7 0.2 3.1 3 1 1 4 4 4 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 ACS99124.1 - 1.6e-24 87.0 2.9 1.6e-24 87.0 2.9 4.0 3 1 1 4 4 4 1 PPIC-type PPIASE domain SurA_N_3 PF13624.6 ACS99124.1 - 2.9e-11 43.4 3.7 3.6e-10 39.8 0.4 2.8 2 1 1 3 3 3 2 SurA N-terminal domain SurA_N_2 PF13623.6 ACS99124.1 - 3.2e-07 30.3 5.4 0.00079 19.3 0.4 3.1 2 1 1 3 3 3 2 SurA N-terminal domain SurA_N PF09312.11 ACS99124.1 - 7e-05 22.9 0.9 0.00024 21.2 0.9 2.0 1 1 0 1 1 1 1 SurA N-terminal domain Trigger_C PF05698.14 ACS99124.1 - 0.006 16.6 1.1 0.006 16.6 1.1 3.7 3 1 0 3 3 3 1 Bacterial trigger factor protein (TF) C-terminus RIFIN PF02009.16 ACS99124.1 - 0.091 12.6 0.1 0.091 12.6 0.1 3.0 2 1 1 3 3 3 0 Rifin PBP1_TM PF14812.6 ACS99124.1 - 1.4 9.3 6.4 0.14 12.6 0.8 2.3 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal EAL PF00563.20 ACS99125.1 - 4.1e-64 216.3 0.0 6.3e-64 215.7 0.0 1.3 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 ACS99125.1 - 1.9e-43 148.0 0.0 4.4e-43 146.8 0.0 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain MHYT PF03707.16 ACS99125.1 - 2.4e-42 142.9 27.6 1.9e-17 63.2 1.9 4.4 4 0 0 4 4 4 4 Bacterial signalling protein N terminal repeat GCH_III PF05165.12 ACS99125.1 - 0.012 14.9 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 GTP cyclohydrolase III DUF3007 PF11460.8 ACS99125.1 - 0.11 12.8 2.8 0.16 12.2 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) HD_5 PF13487.6 ACS99126.1 - 3.8e-19 68.7 0.0 7.9e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 HD domain HD PF01966.22 ACS99126.1 - 1.6e-16 60.6 0.1 4.6e-16 59.2 0.0 1.8 2 0 0 2 2 2 1 HD domain HD_3 PF13023.6 ACS99126.1 - 8.9e-05 22.5 0.0 0.00021 21.3 0.0 1.6 2 0 0 2 2 2 1 HD domain Ntox23 PF15528.6 ACS99126.1 - 0.012 15.8 0.1 0.018 15.2 0.1 1.2 1 0 0 1 1 1 0 Bacterial toxin 23 HDOD PF08668.12 ACS99126.1 - 0.022 14.3 0.0 0.039 13.4 0.0 1.4 1 0 0 1 1 1 0 HDOD domain DUF5056 PF16479.5 ACS99126.1 - 0.03 14.6 0.1 0.1 12.9 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5056) Aldo_ket_red PF00248.21 ACS99127.1 - 4.1e-69 233.0 0.0 4.6e-69 232.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PilS PF08805.11 ACS99127.1 - 0.11 12.3 0.0 0.29 11.0 0.0 1.6 2 0 0 2 2 2 0 PilS N terminal GrpB PF04229.14 ACS99128.1 - 1.6e-48 164.9 0.0 1.8e-48 164.8 0.0 1.0 1 0 0 1 1 1 1 GrpB protein KNOX2 PF03791.13 ACS99128.1 - 0.42 10.2 2.5 2.9 7.5 0.1 2.5 2 1 0 2 2 2 0 KNOX2 domain Response_reg PF00072.24 ACS99129.1 - 6.7e-35 119.6 0.0 1.7e-25 89.4 0.2 2.8 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 ACS99129.1 - 2.9e-30 105.1 0.1 7.7e-30 103.7 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACS99129.1 - 1.9e-21 75.8 1.2 2.2e-20 72.4 0.0 3.5 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 ACS99129.1 - 6e-18 65.0 0.0 6e-12 45.7 0.0 3.8 3 1 0 3 3 3 2 PAS domain PAS PF00989.25 ACS99129.1 - 1.5e-15 57.2 0.0 3.1e-09 36.8 0.0 3.5 3 0 0 3 3 3 2 PAS fold dCache_1 PF02743.18 ACS99129.1 - 3.2e-15 56.6 2.0 2.3e-14 53.8 0.3 2.7 2 1 0 2 2 2 1 Cache domain PAS_4 PF08448.10 ACS99129.1 - 7.4e-12 45.5 0.1 1.2e-06 28.7 0.0 3.9 3 1 0 3 3 3 2 PAS fold PAS_8 PF13188.7 ACS99129.1 - 8.8e-09 35.2 0.0 2.7e-05 24.1 0.0 2.9 2 0 0 2 2 2 2 PAS domain Hpt PF01627.23 ACS99129.1 - 1.3e-07 31.8 0.5 4.4e-07 30.1 0.5 1.9 1 0 0 1 1 1 1 Hpt domain PAS_3 PF08447.12 ACS99129.1 - 2.4e-06 27.7 0.1 0.00025 21.3 0.1 3.1 2 1 0 2 2 2 1 PAS fold HAMP PF00672.25 ACS99129.1 - 1.6e-05 25.1 0.0 5.7e-05 23.4 0.0 2.0 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 ACS99129.1 - 7.6e-05 22.6 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pfg27 PF09216.10 ACS99129.1 - 0.16 11.8 0.0 0.39 10.5 0.0 1.6 1 0 0 1 1 1 0 Pfg27 Response_reg PF00072.24 ACS99130.1 - 9.4e-30 103.1 0.2 1.7e-29 102.2 0.2 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACS99130.1 - 6.6e-24 83.8 0.0 1.2e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal DUF2786 PF10979.8 ACS99130.1 - 0.22 11.5 3.5 0.22 11.5 2.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2786) EAL PF00563.20 ACS99131.1 - 1.3e-67 227.8 0.0 1.7e-67 227.4 0.0 1.1 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 ACS99131.1 - 3.2e-17 62.7 0.0 4.8e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Peptidase_C4 PF00863.19 ACS99132.1 - 0.086 12.1 0.2 0.088 12.1 0.2 1.1 1 0 0 1 1 1 0 Peptidase family C4 Pkinase PF00069.25 ACS99134.1 - 1.5e-23 83.5 0.0 1.8e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ACS99134.1 - 1.2e-14 54.3 0.0 1.4e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ACS99134.1 - 4.8e-09 36.1 0.0 6.6e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ACS99134.1 - 3.4e-07 30.4 1.8 0.0017 18.3 0.0 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ACS99134.1 - 0.0002 20.3 0.0 0.00023 20.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ACS99134.1 - 0.015 14.6 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sod_Cu PF00080.20 ACS99136.1 - 6.6e-43 146.3 2.4 9e-43 145.9 2.4 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Phage_holin_5_2 PF16079.5 ACS99137.1 - 3e-17 62.7 5.7 3.8e-17 62.4 5.7 1.1 1 0 0 1 1 1 1 Phage holin family Hol44, in holin superfamily V DUF2781 PF10914.8 ACS99137.1 - 0.0037 17.7 1.1 0.0039 17.6 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) PhoR PF11808.8 ACS99137.1 - 0.11 13.0 2.5 0.48 10.9 0.6 2.1 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR DUF760 PF05542.11 ACS99137.1 - 0.11 12.8 0.1 3.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF760) TraL PF07178.11 ACS99137.1 - 0.35 11.4 4.8 1.1 9.8 0.9 2.0 1 1 1 2 2 2 0 TraL protein NUDIX PF00293.28 ACS99138.1 - 2.7e-07 30.7 0.5 3.7e-07 30.2 0.5 1.2 1 0 0 1 1 1 1 NUDIX domain MscL PF01741.18 ACS99139.1 - 4.6e-40 136.7 0.4 5.9e-40 136.3 0.4 1.1 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL UPF0547 PF10571.9 ACS99139.1 - 0.0091 16.1 4.7 0.014 15.5 4.7 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 DZR PF12773.7 ACS99139.1 - 0.018 15.0 0.9 0.029 14.4 0.9 1.2 1 0 0 1 1 1 0 Double zinc ribbon DUF3169 PF11368.8 ACS99139.1 - 0.37 10.3 3.4 0.4 10.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Spo0M PF07070.11 ACS99140.1 - 3.8e-80 268.4 0.0 4.4e-80 268.2 0.0 1.0 1 0 0 1 1 1 1 SpoOM protein Arrestin_C PF02752.22 ACS99140.1 - 0.033 14.6 0.0 0.047 14.2 0.0 1.2 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain ArAE_1 PF06081.11 ACS99141.1 - 9.7e-32 110.0 17.9 1.3e-31 109.6 17.9 1.1 1 0 0 1 1 1 1 Aromatic acid exporter family member 1 FUSC PF04632.12 ACS99141.1 - 2.6e-12 46.1 13.9 1.1e-11 44.1 13.9 1.8 1 1 0 1 1 1 1 Fusaric acid resistance protein family FUSC_2 PF13515.6 ACS99141.1 - 3.4e-06 27.2 15.9 5.2e-06 26.6 15.9 1.3 1 0 0 1 1 1 1 Fusaric acid resistance protein-like ALMT PF11744.8 ACS99141.1 - 0.00073 18.5 0.0 0.0012 17.8 0.0 1.6 1 0 0 1 1 1 1 Aluminium activated malate transporter Serine_rich PF08824.10 ACS99141.1 - 0.082 12.9 1.4 0.53 10.3 1.1 2.3 2 0 0 2 2 2 0 Serine rich protein interaction domain PMP1_2 PF08114.11 ACS99141.1 - 0.56 10.0 3.9 6.3 6.6 0.2 2.7 2 0 0 2 2 2 0 ATPase proteolipid family DUF2955 PF11168.8 ACS99141.1 - 5 7.0 17.2 7.3 6.4 17.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2955) YjzC PF14168.6 ACS99142.1 - 0.025 15.0 1.4 0.16 12.3 1.4 2.3 1 1 0 1 1 1 0 YjzC-like protein SNARE_assoc PF09335.11 ACS99144.1 - 2.2e-21 76.6 5.6 2.2e-21 76.6 5.6 1.9 1 1 2 3 3 3 1 SNARE associated Golgi protein UPF0242 PF06785.11 ACS99144.1 - 0.082 13.0 0.4 0.17 11.9 0.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RseC_MucC PF04246.12 ACS99144.1 - 0.61 10.0 4.0 3 7.8 0.4 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC MFS_1 PF07690.16 ACS99145.1 - 3.6e-46 157.7 59.7 6.3e-29 101.0 30.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ACS99145.1 - 3.1e-12 46.1 30.2 3.2e-08 32.8 14.3 2.1 1 1 1 2 2 2 2 MFS_1 like family Nuc_H_symport PF03825.16 ACS99145.1 - 0.00054 19.1 2.6 0.00054 19.1 2.6 2.4 2 1 0 2 2 2 1 Nucleoside H+ symporter OATP PF03137.20 ACS99145.1 - 6.1 5.0 13.5 0.015 13.6 1.6 2.4 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family MGDG_synth PF06925.11 ACS99146.1 - 1.7e-33 116.1 0.0 2.3e-33 115.7 0.0 1.2 1 0 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.16 ACS99146.1 - 1.1e-08 35.3 0.0 2.2e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glycos_transf_1 PF00534.20 ACS99146.1 - 1.3e-07 31.4 0.0 2.5e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99146.1 - 0.00013 22.4 0.0 0.00027 21.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Epimerase_2 PF02350.19 ACS99146.1 - 0.00074 18.5 0.0 0.0032 16.4 0.0 1.8 2 0 0 2 2 2 1 UDP-N-acetylglucosamine 2-epimerase Glyco_transf_4 PF13439.6 ACS99146.1 - 0.0047 16.9 0.2 0.01 15.8 0.2 1.5 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Aldo_ket_red PF00248.21 ACS99147.1 - 5e-67 226.2 0.0 6.1e-67 225.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PALP PF00291.25 ACS99148.1 - 8.4e-78 261.8 0.2 1e-77 261.5 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 ACS99148.1 - 4.3e-29 100.1 0.0 6.8e-29 99.5 0.0 1.3 1 0 0 1 1 1 1 C-terminal regulatory domain of Threonine dehydratase DUF2012 PF09430.10 ACS99149.1 - 0.029 14.5 0.0 0.053 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) Peripla_BP_3 PF13377.6 ACS99150.1 - 2.2e-41 142.0 0.0 6.9e-41 140.3 0.0 1.7 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACS99150.1 - 2.3e-32 112.6 0.0 3e-32 112.2 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACS99150.1 - 1.9e-20 72.4 1.2 4.5e-20 71.2 1.2 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACS99150.1 - 1.8e-18 67.1 0.0 4.4e-18 65.8 0.0 1.7 2 1 0 2 2 2 1 Periplasmic binding protein domain HTH_3 PF01381.22 ACS99150.1 - 0.011 15.8 0.1 0.031 14.3 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix HTH_7 PF02796.15 ACS99150.1 - 0.023 14.7 0.2 0.36 10.9 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HTH_31 PF13560.6 ACS99150.1 - 0.028 14.7 0.0 0.073 13.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain NAD_binding_11 PF14833.6 ACS99150.1 - 0.04 14.2 0.0 0.08 13.2 0.0 1.4 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase HTH_Tnp_ISL3 PF13542.6 ACS99150.1 - 0.095 12.1 0.1 0.62 9.5 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 ACS99150.1 - 0.098 12.5 0.2 1.6 8.6 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain Peripla_BP_3 PF13377.6 ACS99151.1 - 1.4e-34 119.9 0.0 4e-34 118.3 0.0 1.7 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACS99151.1 - 6.1e-34 117.7 0.0 8.2e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACS99151.1 - 2.3e-19 68.9 2.1 4.6e-19 67.9 2.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACS99151.1 - 3.7e-15 56.2 0.3 1.1e-14 54.7 0.3 1.7 1 1 1 2 2 2 1 Periplasmic binding protein domain LYTB PF02401.18 ACS99151.1 - 0.015 14.6 0.5 0.023 14.0 0.5 1.3 1 0 0 1 1 1 0 LytB protein HTH_7 PF02796.15 ACS99151.1 - 0.1 12.7 0.4 2.9 8.0 0.1 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase BPD_transp_1 PF00528.22 ACS99152.1 - 5.8e-17 62.0 14.7 5.8e-17 62.0 14.7 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SH PF01445.17 ACS99152.1 - 1.3 9.0 7.6 0.59 10.1 2.4 3.0 2 0 0 2 2 2 0 Viral small hydrophobic protein BPD_transp_1 PF00528.22 ACS99153.1 - 1.6e-10 41.0 19.9 8.5e-10 38.7 19.6 2.1 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component 7tm_3 PF00003.22 ACS99153.1 - 0.1 12.3 11.5 0.0099 15.6 6.8 1.6 2 0 0 2 2 2 0 7 transmembrane sweet-taste receptor of 3 GCPR DUF3502 PF12010.8 ACS99154.1 - 5.9e-23 81.9 2.2 7.3e-23 81.6 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACS99154.1 - 1.4e-14 54.8 14.2 2.9e-14 53.7 14.2 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Glyco_hydro_2_C PF02836.17 ACS99155.1 - 1.1e-27 96.9 0.1 2.8e-27 95.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 ACS99155.1 - 6.8e-17 61.9 0.0 1.3e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 ACS99155.1 - 2.8e-09 37.6 0.0 5.1e-08 33.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 DUF1965 PF09248.10 ACS99155.1 - 0.0013 18.5 0.4 1.6 8.5 0.1 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF1965) BetaGal_dom4_5 PF13364.6 ACS99155.1 - 0.086 13.4 0.0 0.26 11.8 0.0 1.8 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain Glyco_hydro_30 PF02055.16 ACS99156.1 - 2.9e-50 171.2 0.6 3.6e-50 170.9 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 ACS99156.1 - 3.9e-16 59.1 0.2 5.8e-16 58.6 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30C PF17189.4 ACS99156.1 - 1.1e-15 57.6 0.0 2.7e-15 56.3 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydr_30_2 PF14587.6 ACS99156.1 - 2.3e-09 37.3 0.0 0.00094 18.9 0.0 2.1 2 0 0 2 2 2 2 O-Glycosyl hydrolase family 30 ABC2_membrane_3 PF12698.7 ACS99156.1 - 0.23 10.5 0.0 0.34 10.0 0.0 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Glyco_hydro_30 PF02055.16 ACS99157.1 - 3.1e-31 108.6 0.1 5.6e-31 107.8 0.1 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 ACS99157.1 - 3.7e-13 49.5 0.0 8.4e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 ACS99157.1 - 1.2e-07 31.3 0.0 2.1e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 adh_short PF00106.25 ACS99158.1 - 3.7e-29 101.6 0.0 3.8e-28 98.3 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACS99158.1 - 2.7e-17 63.1 0.1 2.4e-16 60.0 0.1 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ACS99158.1 - 0.00066 19.2 0.0 0.00097 18.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ACS99158.1 - 0.0061 16.5 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 KR domain NAD_binding_7 PF13241.6 ACS99158.1 - 0.054 13.9 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding AdoHcyase_NAD PF00670.21 ACS99158.1 - 0.13 12.4 0.1 0.29 11.2 0.1 1.6 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AraC_N PF06719.13 ACS99159.1 - 1.5e-48 164.2 0.1 2e-48 163.8 0.1 1.2 1 0 0 1 1 1 1 AraC-type transcriptional regulator N-terminus HTH_18 PF12833.7 ACS99159.1 - 1.5e-22 79.7 0.2 4.3e-22 78.2 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99159.1 - 1.4e-11 44.2 0.0 2.8e-05 24.1 0.0 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family TetR_N PF00440.23 ACS99159.1 - 0.0014 18.4 0.0 0.01 15.6 0.0 2.5 3 0 0 3 3 3 1 Bacterial regulatory proteins, tetR family AraC_binding PF02311.19 ACS99159.1 - 0.0058 16.5 0.1 0.019 14.9 0.1 1.9 1 1 0 1 1 1 1 AraC-like ligand binding domain AbiEi_4 PF13338.6 ACS99159.1 - 0.089 13.0 0.0 12 6.1 0.0 3.5 2 1 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin HTH_11 PF08279.12 ACS99159.1 - 0.12 12.3 1.6 3 7.8 0.0 2.8 3 0 0 3 3 3 0 HTH domain Flavodoxin_1 PF00258.25 ACS99162.1 - 2.4e-32 112.1 0.2 2.8e-32 111.9 0.2 1.0 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 ACS99162.1 - 1.9e-08 34.7 0.0 3e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_3 PF12641.7 ACS99162.1 - 1.5e-05 24.8 0.0 1.9e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin domain FMN_red PF03358.15 ACS99162.1 - 0.00061 19.6 0.0 0.00086 19.1 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_NdrI PF07972.11 ACS99162.1 - 0.046 13.9 0.0 0.063 13.4 0.0 1.1 1 0 0 1 1 1 0 NrdI Flavodoxin like HTH_18 PF12833.7 ACS99164.1 - 7.3e-20 71.0 0.5 1.7e-19 69.8 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99164.1 - 1e-10 41.4 0.0 6.5e-06 26.1 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99164.1 - 2.7e-06 27.3 1.0 5.1e-06 26.4 1.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99164.1 - 2.4e-05 23.9 0.0 3.6e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Cupin domain DUF1971 PF09313.11 ACS99164.1 - 0.082 12.9 0.0 0.51 10.4 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1971) SRAP PF02586.14 ACS99165.1 - 3.2e-44 151.1 0.1 3.6e-44 150.9 0.1 1.0 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) ETF PF01012.21 ACS99166.1 - 1.3e-44 152.3 6.9 1.8e-44 151.8 6.9 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 ACS99166.1 - 1.8e-33 114.4 4.8 2.5e-33 113.9 2.6 2.1 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.21 ACS99167.1 - 3.4e-41 141.1 6.0 4.9e-41 140.6 6.0 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain CCG PF02754.16 ACS99168.1 - 1.4e-23 82.9 0.2 6.5e-17 61.5 0.1 2.8 3 0 0 3 3 3 2 Cysteine-rich domain Fer4_8 PF13183.6 ACS99168.1 - 1e-11 45.1 5.4 5.2e-11 42.8 5.4 2.2 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 ACS99168.1 - 5.4e-08 32.9 6.4 0.0025 17.9 0.5 2.9 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 ACS99168.1 - 9.2e-08 32.6 4.8 4.1e-07 30.5 2.8 2.7 2 1 0 2 2 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 ACS99168.1 - 4.3e-07 30.8 6.8 0.0039 18.1 0.7 2.6 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 ACS99168.1 - 6.3e-06 26.2 15.9 2.6e-05 24.2 12.4 2.9 3 1 0 3 3 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 ACS99168.1 - 1.3e-05 25.7 8.0 0.038 14.6 0.1 3.2 4 0 0 4 4 3 2 4Fe-4S dicluster domain Fer4_22 PF17179.4 ACS99168.1 - 9.9e-05 23.1 3.5 0.015 16.1 0.2 3.5 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 ACS99168.1 - 0.00025 21.1 5.9 0.21 11.7 0.6 2.6 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 ACS99168.1 - 0.00064 19.7 2.2 0.00064 19.7 2.2 3.3 4 0 0 4 4 3 2 4Fe-4S binding domain Fer4 PF00037.27 ACS99168.1 - 0.0031 17.3 20.7 0.0077 16.0 2.8 2.9 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_4 PF12800.7 ACS99168.1 - 0.0052 17.2 1.3 0.0052 17.2 1.3 2.9 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_18 PF13746.6 ACS99168.1 - 0.0082 16.3 2.8 2.2 8.5 0.2 2.6 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 ACS99168.1 - 0.016 15.2 3.4 0.016 15.2 3.4 3.0 3 0 0 3 3 3 0 4Fe-4S binding domain 3HCDH_N PF02737.18 ACS99169.1 - 3.4e-45 154.1 0.0 8e-45 152.9 0.0 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ACS99169.1 - 8.4e-18 64.8 0.1 1.8e-10 41.3 0.0 3.0 3 0 0 3 3 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_1 PF00378.20 ACS99169.1 - 4.5e-10 39.3 0.1 8.7e-10 38.3 0.1 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ACS99169.1 - 3.8e-09 36.5 0.1 6.2e-09 35.8 0.1 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NAD_binding_2 PF03446.15 ACS99169.1 - 0.00066 19.9 0.3 0.0018 18.4 0.3 1.9 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DAO PF01266.24 ACS99169.1 - 0.0019 17.9 0.1 0.0065 16.1 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase ApbA PF02558.16 ACS99169.1 - 0.0025 17.5 0.0 0.0049 16.5 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 ACS99169.1 - 0.0025 17.1 0.1 0.0047 16.2 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ACS99169.1 - 0.0087 16.3 0.5 0.026 14.8 0.5 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 ACS99169.1 - 0.067 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FliT PF05400.13 ACS99169.1 - 0.08 13.8 0.7 0.38 11.6 0.0 2.3 2 0 0 2 2 2 0 Flagellar protein FliT Thiolase_N PF00108.23 ACS99170.1 - 2.5e-77 259.8 5.3 9.2e-77 257.9 5.3 1.8 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ACS99170.1 - 6.8e-47 158.2 1.2 1.5e-46 157.0 1.2 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ACS99170.1 - 6.1e-09 35.8 0.6 2.4e-08 33.8 0.1 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 ACS99170.1 - 0.018 14.9 1.0 3.5 7.6 0.1 2.8 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 ACS99170.1 - 0.066 13.4 0.0 0.23 11.7 0.0 2.0 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal DUF3789 PF12664.7 ACS99170.1 - 1.3 8.8 7.5 4.4 7.1 7.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3789) Acyl-CoA_dh_1 PF00441.24 ACS99171.1 - 6.7e-37 127.0 3.3 2.8e-35 121.7 0.1 2.8 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ACS99171.1 - 1.4e-29 103.0 0.1 2.9e-29 102.0 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ACS99171.1 - 2.5e-24 85.3 0.0 5.5e-24 84.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ACS99171.1 - 8.3e-13 48.8 0.3 2e-11 44.3 0.0 2.6 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain S4_2 PF13275.6 ACS99171.1 - 0.052 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 S4 domain DUF1974 PF09317.11 ACS99171.1 - 0.084 12.4 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) AMP-binding PF00501.28 ACS99172.1 - 5.8e-113 377.7 0.0 7.6e-113 377.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ACS99172.1 - 3e-18 66.6 0.1 3e-18 66.6 0.1 2.3 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain 4HBT PF03061.22 ACS99173.1 - 1.9e-15 56.9 0.3 3.1e-15 56.3 0.3 1.3 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 ACS99173.1 - 8.9e-07 29.1 0.1 1.1e-06 28.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) 4HBT_3 PF13622.6 ACS99173.1 - 0.0027 18.0 0.0 0.0037 17.6 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily LPAM_1 PF08139.12 ACS99176.1 - 5.3e-05 23.5 0.1 7.4e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site Conotoxin PF02950.17 ACS99176.1 - 0.01 16.8 0.3 0.014 16.4 0.3 1.2 1 0 0 1 1 1 0 Conotoxin OSTbeta PF15048.6 ACS99176.1 - 0.035 14.2 0.0 0.04 14.1 0.0 1.1 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein DUF4576 PF15144.6 ACS99176.1 - 0.037 13.9 4.1 0.13 12.2 4.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4576) Response_reg PF00072.24 ACS99177.1 - 7.9e-32 109.8 0.0 1.1e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACS99177.1 - 8.7e-29 99.4 0.0 1.5e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HATPase_c PF02518.26 ACS99178.1 - 2.8e-26 92.2 0.1 5e-26 91.4 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACS99178.1 - 2.7e-18 65.8 1.0 2.7e-18 65.8 1.0 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACS99178.1 - 3.9e-06 27.1 1.0 3.9e-06 27.1 1.0 3.1 3 0 0 3 3 3 1 HAMP domain HATPase_c_5 PF14501.6 ACS99178.1 - 6.9e-05 22.7 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 ACS99178.1 - 0.00084 19.2 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Keratin_assoc PF09775.9 ACS99178.1 - 0.023 14.3 2.4 0.037 13.7 2.4 1.3 1 0 0 1 1 1 0 Keratinocyte-associated protein 2 DUF1974 PF09317.11 ACS99178.1 - 0.025 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) Wzy_C PF04932.15 ACS99178.1 - 0.047 13.3 2.7 0.051 13.2 2.1 1.5 1 1 1 2 2 2 0 O-Antigen ligase SNARE_assoc PF09335.11 ACS99178.1 - 0.055 14.0 1.4 0.099 13.1 1.4 1.4 1 0 0 1 1 1 0 SNARE associated Golgi protein CoA_binding_3 PF13727.6 ACS99178.1 - 0.16 12.0 3.6 0.13 12.2 1.7 1.8 2 0 0 2 2 2 0 CoA-binding domain DUF2207 PF09972.9 ACS99178.1 - 2.2 6.9 4.3 3 6.5 4.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Oxidored_molyb PF00174.19 ACS99179.1 - 6.3e-34 117.1 0.1 1.1e-33 116.3 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain TAT_signal PF10518.9 ACS99179.1 - 0.0012 18.6 0.4 0.0041 16.9 0.4 2.0 1 1 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence Ni_hydr_CYTB PF01292.20 ACS99179.1 - 0.0039 16.8 18.2 0.011 15.3 17.5 2.1 2 1 0 2 2 2 1 Prokaryotic cytochrome b561 DUF4405 PF14358.6 ACS99179.1 - 0.15 12.6 18.0 1.5 9.4 5.5 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) PepSY_TM PF03929.16 ACS99179.1 - 0.18 11.5 17.7 0.95 9.1 2.9 2.3 1 1 1 2 2 2 0 PepSY-associated TM region DUF2530 PF10745.9 ACS99179.1 - 0.82 10.0 5.5 0.48 10.7 1.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Collagen PF01391.18 ACS99180.1 - 1.7e-09 37.3 19.0 2.7e-09 36.6 19.0 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) DUF4386 PF14329.6 ACS99181.1 - 8.7e-54 182.6 21.1 9.8e-54 182.4 21.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4386) TMEM40 PF15817.5 ACS99181.1 - 0.84 9.4 5.0 0.18 11.6 0.8 1.9 2 0 0 2 2 2 0 Transmembrane protein 40 family HTH_3 PF01381.22 ACS99182.1 - 4.3e-14 52.3 0.0 4.9e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 ACS99182.1 - 8.1e-11 41.8 0.0 9.9e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ACS99182.1 - 6.5e-07 29.6 0.0 7.7e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4 PF04545.16 ACS99182.1 - 0.00018 20.9 0.1 0.00041 19.8 0.0 1.6 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_Crp_2 PF13545.6 ACS99182.1 - 0.0014 18.5 0.0 0.0021 18.0 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_11 PF08279.12 ACS99182.1 - 0.0028 17.6 0.0 0.0046 16.9 0.0 1.4 1 0 0 1 1 1 1 HTH domain HTH_26 PF13443.6 ACS99182.1 - 0.0072 16.7 0.0 0.0081 16.6 0.0 1.1 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain Phage_CI_repr PF07022.13 ACS99182.1 - 0.0093 16.0 0.0 0.0094 16.0 0.0 1.1 1 0 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain HTH_24 PF13412.6 ACS99182.1 - 0.019 14.5 0.1 0.038 13.5 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding MerR PF00376.23 ACS99182.1 - 0.022 14.5 0.0 0.26 11.1 0.0 2.2 2 0 0 2 2 2 0 MerR family regulatory protein HTH_CodY PF08222.11 ACS99182.1 - 0.032 13.8 0.0 0.067 12.8 0.0 1.5 2 0 0 2 2 2 0 CodY helix-turn-helix domain YdaS_antitoxin PF15943.5 ACS99182.1 - 0.04 13.8 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_25 PF13413.6 ACS99182.1 - 0.041 13.8 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_psq PF05225.16 ACS99182.1 - 0.089 12.6 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_7 PF02796.15 ACS99182.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Crp PF00325.20 ACS99182.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family MarR PF01047.22 ACS99182.1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.5 1 1 0 1 1 1 0 MarR family DUF3488 PF11992.8 ACS99183.1 - 0.0037 16.3 3.6 0.0076 15.2 3.6 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3488) EI24 PF07264.11 ACS99183.1 - 0.0083 16.4 4.5 0.012 15.9 4.5 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF2178 PF09946.9 ACS99183.1 - 0.017 15.3 3.8 0.067 13.4 3.7 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2178) DUF973 PF06157.11 ACS99183.1 - 0.067 12.2 6.7 0.087 11.9 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF973) Saf_2TM PF18303.1 ACS99183.1 - 0.11 12.1 3.0 0.094 12.3 2.0 1.4 1 1 0 1 1 1 0 SAVED-fused 2TM effector domain DUF4271 PF14093.6 ACS99183.1 - 0.15 12.0 11.9 0.9 9.4 11.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) Colicin_V PF02674.16 ACS99183.1 - 0.28 11.2 8.1 0.044 13.7 1.6 2.3 2 1 0 2 2 2 0 Colicin V production protein DUF4131 PF13567.6 ACS99183.1 - 0.29 10.8 2.7 4.9 6.8 1.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF1467 PF07330.12 ACS99183.1 - 0.76 9.8 3.7 1 9.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) FixQ PF05545.11 ACS99183.1 - 1.1 9.3 5.9 4.4 7.4 0.3 3.4 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ TnpW PF14202.6 ACS99184.1 - 0.12 12.2 1.1 0.88 9.5 2.1 1.9 2 0 0 2 2 2 0 Transposon-encoded protein TnpW Rhodanese PF00581.20 ACS99185.1 - 2.2e-38 131.1 0.0 1.9e-20 73.3 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain DUF2103 PF09876.9 ACS99185.1 - 0.046 13.7 0.0 0.078 13.0 0.0 1.4 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2103) HEPN_Apea PF18739.1 ACS99186.1 - 0.002 18.5 5.5 0.0051 17.2 1.4 3.0 2 1 0 2 2 2 1 Apea-like HEPN CSTF1_dimer PF16699.5 ACS99186.1 - 0.091 12.5 0.1 0.19 11.5 0.1 1.5 1 0 0 1 1 1 0 Cleavage stimulation factor subunit 1, dimerisation domain AAA_31 PF13614.6 ACS99187.1 - 4.2e-26 91.9 0.0 5.8e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 ACS99187.1 - 5.7e-09 36.1 0.0 2.4e-08 34.1 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 ACS99187.1 - 8.9e-06 25.2 0.0 0.0012 18.2 0.0 2.2 2 0 0 2 2 2 2 ATPase MipZ ParA PF10609.9 ACS99187.1 - 1.1e-05 25.1 0.0 3.4e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase ArsA_ATPase PF02374.15 ACS99187.1 - 1.3e-05 24.6 0.2 0.00015 21.1 0.0 2.4 3 0 0 3 3 3 1 Anion-transporting ATPase CBP_BcsQ PF06564.12 ACS99187.1 - 0.00035 20.1 0.0 0.33 10.4 0.0 2.1 2 0 0 2 2 2 2 Cellulose biosynthesis protein BcsQ VirC1 PF07015.11 ACS99187.1 - 0.002 17.4 0.1 1.7 7.9 0.0 2.2 2 0 0 2 2 2 2 VirC1 protein SRP54 PF00448.22 ACS99187.1 - 0.018 14.7 0.0 0.26 10.9 0.0 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Fer4_NifH PF00142.18 ACS99187.1 - 0.042 13.3 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_24 PF13479.6 ACS99187.1 - 0.049 13.3 0.0 0.25 11.0 0.0 2.2 2 1 0 2 2 2 0 AAA domain stn_TNFRSF12A PF12191.8 ACS99189.1 - 0.039 14.2 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain PhyH PF05721.13 ACS99190.1 - 1.3e-38 133.4 0.2 1.6e-38 133.1 0.2 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HTH_AraC PF00165.23 ACS99191.1 - 1.3e-18 66.6 0.0 4.5e-08 33.0 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACS99191.1 - 1.2e-16 60.8 0.0 2.7e-16 59.6 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain Cupin_6 PF12852.7 ACS99191.1 - 8.2e-07 28.9 0.0 4e-06 26.7 0.0 1.9 1 1 0 1 1 1 1 Cupin Cupin_2 PF07883.11 ACS99191.1 - 9e-07 28.5 0.0 1.7e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACS99191.1 - 1.6e-05 24.8 0.1 5.7e-05 23.0 0.1 1.9 1 1 0 1 1 1 1 AraC-like ligand binding domain AraC_binding_2 PF14525.6 ACS99191.1 - 0.00026 20.7 0.0 0.0004 20.1 0.0 1.2 1 0 0 1 1 1 1 AraC-binding-like domain Oxidored_FMN PF00724.20 ACS99192.1 - 2e-64 218.0 0.0 1.6e-36 126.3 0.0 3.0 1 1 1 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family AP_endonuc_2 PF01261.24 ACS99192.1 - 0.02 14.3 0.1 1.1 8.7 0.0 2.9 2 1 0 2 2 2 0 Xylose isomerase-like TIM barrel TPR_10 PF13374.6 ACS99192.1 - 0.079 12.9 0.8 0.27 11.2 0.0 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ATPgrasp_YheCD PF14398.6 ACS99193.1 - 7.2e-75 251.5 0.5 8.4e-75 251.3 0.5 1.1 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACS99193.1 - 1.9e-09 37.2 0.0 2.2e-05 23.9 0.0 2.1 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp GSH-S_ATP PF02955.16 ACS99193.1 - 2.9e-05 23.5 0.2 0.00031 20.2 0.2 2.3 1 1 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain TTL PF03133.15 ACS99193.1 - 0.0026 17.0 0.1 0.51 9.4 0.0 2.3 2 1 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ACS99194.1 - 1.6e-71 240.6 1.5 2e-71 240.2 1.5 1.1 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACS99194.1 - 2e-09 37.1 0.1 7.2e-05 22.2 0.1 2.1 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp RimK PF08443.11 ACS99194.1 - 4.1e-05 23.3 0.2 0.0054 16.3 0.2 2.7 1 1 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 ACS99194.1 - 5.7e-05 22.6 0.4 0.0012 18.3 0.4 2.5 1 1 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain DUF1491 PF07372.12 ACS99194.1 - 0.12 12.8 0.6 3.3 8.1 0.1 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF1491) ATPgrasp_YheCD PF14398.6 ACS99195.1 - 1.3e-61 208.1 0.1 1.7e-61 207.7 0.1 1.1 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACS99195.1 - 2.2e-05 23.8 0.0 0.15 11.3 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp TTL PF03133.15 ACS99195.1 - 0.0027 16.9 0.0 0.0064 15.7 0.0 1.6 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_3 PF02655.14 ACS99195.1 - 0.0044 17.1 0.3 0.012 15.7 0.3 1.8 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ACS99195.1 - 0.027 14.0 0.0 0.052 13.1 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus DUF4144 PF13642.6 ACS99195.1 - 0.18 12.4 0.0 0.51 10.9 0.0 1.8 1 0 0 1 1 1 0 protein structure with unknown function Glyco_trans_2_3 PF13632.6 ACS99196.1 - 9.5e-29 100.7 0.5 9.5e-29 100.7 0.5 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ACS99196.1 - 2.6e-15 57.0 0.1 1e-10 41.9 0.0 2.4 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ACS99196.1 - 6.9e-11 42.2 0.0 3.6e-06 26.9 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ACS99196.1 - 0.00014 21.4 0.0 0.00061 19.3 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.15 ACS99196.1 - 0.0091 14.7 0.0 0.65 8.5 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase HTH_17 PF12728.7 ACS99196.1 - 0.026 14.7 0.1 0.1 12.8 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain DUF2839 PF10999.8 ACS99196.1 - 0.061 13.7 2.1 8.1 6.9 0.0 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF2839) Glyco_hydro_18 PF00704.28 ACS99197.1 - 2.5e-10 40.6 0.6 1.4e-09 38.1 0.1 2.1 2 1 0 2 2 2 1 Glycosyl hydrolases family 18 CBM_5_12 PF02839.14 ACS99197.1 - 0.01 16.4 1.8 0.01 16.4 1.8 4.3 4 0 0 4 4 4 0 Carbohydrate binding domain DUF5360 PF17314.2 ACS99197.1 - 0.14 12.3 0.0 21 5.2 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5360) CBM_5_12_2 PF14600.6 ACS99197.1 - 0.31 11.0 4.0 3 7.9 0.6 2.7 2 0 0 2 2 2 0 Cellulose-binding domain Glyco_hyd_65N_2 PF14498.6 ACS99198.1 - 2.3e-06 27.6 0.0 0.00052 19.9 0.0 2.3 1 1 0 2 2 2 2 Glycosyl hydrolase family 65, N-terminal domain HTH_38 PF13936.6 ACS99198.1 - 0.0099 15.6 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain SBP_bac_1 PF01547.25 ACS99199.1 - 4.1e-10 40.1 15.6 1.5e-09 38.2 15.6 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACS99200.1 - 1.2e-16 61.0 18.1 1.2e-16 61.0 18.1 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99201.1 - 2.5e-13 50.2 12.2 2.5e-13 50.2 12.2 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF373 PF04123.13 ACS99201.1 - 0.039 13.4 2.3 0.057 12.9 2.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF373) DUF2768 PF10966.8 ACS99201.1 - 8 7.0 12.3 0.32 11.5 0.3 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2768) Peripla_BP_3 PF13377.6 ACS99202.1 - 1e-22 81.3 0.0 1.6e-22 80.6 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACS99202.1 - 6.2e-16 58.6 0.0 9.8e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family GntR PF00392.21 ACS99202.1 - 9e-15 54.1 0.0 2e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Peripla_BP_4 PF13407.6 ACS99202.1 - 2.4e-13 50.3 0.0 3.4e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_36 PF13730.6 ACS99202.1 - 6.8e-05 22.7 0.1 0.00037 20.4 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_41 PF14502.6 ACS99202.1 - 0.04 13.6 0.0 0.092 12.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain NYN_YacP PF05991.11 ACS99202.1 - 0.061 13.3 0.5 0.44 10.5 0.3 2.1 2 0 0 2 2 2 0 YacP-like NYN domain Terminase_3C PF17288.2 ACS99202.1 - 0.08 13.3 0.2 0.13 12.6 0.2 1.4 1 0 0 1 1 1 0 Terminase RNAseH like domain Gluconate_2-dh3 PF13618.6 ACS99203.1 - 6.8e-25 87.9 0.0 1.1e-24 87.3 0.0 1.3 1 0 0 1 1 1 1 Gluconate 2-dehydrogenase subunit 3 GMC_oxred_N PF00732.19 ACS99203.1 - 1.6e-19 70.4 1.0 4.7e-19 68.9 1.0 1.8 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ACS99203.1 - 7.6e-19 68.7 0.4 2.7e-18 66.9 0.4 1.9 1 1 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 ACS99203.1 - 2.8e-07 30.1 0.2 0.00032 20.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ACS99203.1 - 1.3e-05 24.5 6.8 0.00042 19.5 4.2 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 ACS99203.1 - 1.5e-05 25.1 0.1 5e-05 23.4 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ACS99203.1 - 4.6e-05 22.8 0.2 6.8e-05 22.3 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ACS99203.1 - 6.9e-05 23.3 0.3 0.00062 20.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ACS99203.1 - 0.0016 17.2 0.9 0.0025 16.6 0.9 1.2 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 ACS99203.1 - 0.0018 17.4 0.3 0.0033 16.5 0.3 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 ACS99203.1 - 0.0053 16.4 6.9 0.011 15.4 0.6 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ACS99203.1 - 0.0059 16.0 4.9 0.0085 15.5 4.9 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ACS99203.1 - 0.016 14.4 0.1 0.029 13.6 0.1 1.3 1 0 0 1 1 1 0 Thi4 family ApbA PF02558.16 ACS99203.1 - 0.041 13.5 0.2 0.085 12.5 0.2 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Fer4_10 PF13237.6 ACS99203.1 - 0.055 13.6 3.4 0.1 12.7 3.4 1.3 1 0 0 1 1 1 0 4Fe-4S dicluster domain Pyr_redox_3 PF13738.6 ACS99203.1 - 0.063 12.5 0.9 0.15 11.2 0.5 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 ACS99203.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 ThiF family Fer4_2 PF12797.7 ACS99203.1 - 0.15 12.2 3.0 0.28 11.4 3.0 1.4 1 0 0 1 1 1 0 4Fe-4S binding domain 3HCDH_N PF02737.18 ACS99203.1 - 0.22 11.4 0.2 0.38 10.6 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain YCII PF03795.14 ACS99204.1 - 2.3e-16 60.0 0.0 2.9e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Sigma70_r2 PF04542.14 ACS99205.1 - 1.5e-07 31.0 0.6 4e-07 29.7 0.6 1.7 1 0 0 1 1 1 1 Sigma-70 region 2 TPR_8 PF13181.6 ACS99205.1 - 0.00021 21.3 0.0 0.00083 19.4 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ACS99205.1 - 0.0026 17.5 1.6 0.0096 15.7 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ACS99205.1 - 0.034 14.2 0.1 0.034 14.2 0.1 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ACS99205.1 - 0.046 14.6 12.6 0.067 14.1 0.1 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat HTH_18 PF12833.7 ACS99206.1 - 6.1e-22 77.7 3.1 4e-21 75.1 1.7 2.5 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99206.1 - 8.8e-20 70.3 1.3 8.2e-12 44.9 0.1 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99206.1 - 2.2e-05 24.4 0.1 7.6e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99206.1 - 0.0013 18.4 0.0 0.0024 17.6 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_N PF06719.13 ACS99206.1 - 0.043 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 AraC-type transcriptional regulator N-terminus Cupin_3 PF05899.12 ACS99206.1 - 0.058 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF861) PhyH PF05721.13 ACS99207.1 - 3.7e-09 37.2 0.0 6.2e-09 36.4 0.0 1.4 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Amidase PF01425.21 ACS99208.1 - 7.5e-70 236.1 2.7 4e-69 233.7 2.7 1.9 1 1 0 1 1 1 1 Amidase SLH PF00395.20 ACS99208.1 - 2.5e-50 168.2 2.6 8.5e-16 57.7 0.4 4.0 3 0 0 3 3 3 3 S-layer homology domain Sigma70_r2 PF04542.14 ACS99210.1 - 1.9e-16 59.5 0.1 3.7e-16 58.6 0.1 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACS99210.1 - 1.5e-09 37.4 0.4 3.3e-09 36.3 0.4 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACS99210.1 - 1.9e-05 24.1 1.7 4.2e-05 23.0 1.7 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACS99210.1 - 0.0046 16.9 0.3 0.0082 16.1 0.3 1.5 1 0 0 1 1 1 1 ECF sigma factor Lant_dehydr_C PF14028.6 ACS99210.1 - 0.048 13.2 0.4 0.06 12.9 0.4 1.2 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term Metallophos PF00149.28 ACS99212.1 - 3.1e-16 60.5 0.1 4e-16 60.1 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACS99212.1 - 2e-06 28.1 0.0 3.6e-05 24.0 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF763 PF05559.11 ACS99212.1 - 0.19 10.9 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF763) HTH_18 PF12833.7 ACS99213.1 - 3.9e-17 62.3 0.5 8.6e-17 61.2 0.4 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain Cass2 PF14526.6 ACS99213.1 - 1.9e-14 54.0 0.1 1.7e-13 51.0 0.1 2.1 1 1 0 1 1 1 1 Integron-associated effector binding protein GyrI-like PF06445.15 ACS99213.1 - 4.3e-10 40.1 0.1 1.5e-09 38.4 0.1 1.8 1 1 0 1 1 1 1 GyrI-like small molecule binding domain HTH_AraC PF00165.23 ACS99213.1 - 3.4e-08 33.4 0.0 3.9e-06 26.8 0.0 2.6 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix proteins, AraC family MCPsignal PF00015.21 ACS99214.1 - 1.4e-43 148.6 24.4 1.4e-43 148.6 24.4 5.0 2 1 3 5 5 5 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 ACS99214.1 - 4.2e-19 68.7 5.9 1.2e-16 60.9 0.0 5.2 5 2 0 5 5 5 1 HAMP domain dCache_1 PF02743.18 ACS99214.1 - 5.5e-16 59.1 4.1 1.4e-15 57.8 0.1 3.0 3 0 0 3 3 3 1 Cache domain DUF948 PF06103.11 ACS99214.1 - 5.6e-05 23.3 27.9 0.078 13.2 2.9 6.5 2 1 3 5 5 5 2 Bacterial protein of unknown function (DUF948) Lsr2 PF11774.8 ACS99214.1 - 0.026 14.7 3.1 0.08 13.1 2.4 2.2 1 1 1 2 2 2 0 Lsr2 Laminin_I PF06008.14 ACS99214.1 - 0.028 14.1 16.4 0.86 9.3 0.0 4.1 2 2 2 4 4 4 0 Laminin Domain I Vps5 PF09325.10 ACS99214.1 - 0.031 13.8 13.1 2.8 7.4 1.6 3.4 2 1 1 3 3 3 0 Vps5 C terminal like BLOC1_2 PF10046.9 ACS99214.1 - 0.11 12.8 11.7 2.4 8.5 0.1 4.8 3 2 2 5 5 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 V_ATPase_I PF01496.19 ACS99214.1 - 0.18 9.7 7.3 0.27 9.1 7.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family eIF3_N PF09440.10 ACS99214.1 - 0.22 12.0 3.7 1.5 9.3 0.1 3.3 1 1 1 3 3 3 0 eIF3 subunit 6 N terminal domain Sec34 PF04136.15 ACS99214.1 - 0.43 10.5 9.3 4.7 7.1 0.8 4.2 2 2 1 4 4 4 0 Sec34-like family GldM_N PF12081.8 ACS99214.1 - 0.53 10.4 11.3 0.14 12.2 1.4 3.3 1 1 3 4 4 4 0 GldM N-terminal domain DUF2203 PF09969.9 ACS99214.1 - 0.56 10.9 12.9 3.1 8.5 0.4 4.1 1 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF725 PF05267.12 ACS99214.1 - 0.66 10.0 11.2 4.5 7.3 1.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF725) Laminin_II PF06009.12 ACS99214.1 - 0.71 9.9 26.5 1.7 8.6 2.8 4.7 2 2 2 4 4 4 0 Laminin Domain II SHE3 PF17078.5 ACS99214.1 - 0.8 9.4 3.2 16 5.2 0.6 2.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 DUF1664 PF07889.12 ACS99214.1 - 0.92 9.6 18.6 1.4 9.0 2.2 4.6 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 ACS99214.1 - 1.6 8.9 12.9 13 6.0 0.4 4.1 2 2 1 3 3 3 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 ACS99214.1 - 2 8.8 9.1 0.54 10.7 1.6 2.4 1 1 0 2 2 2 0 Fez1 APG17 PF04108.12 ACS99214.1 - 2.2 7.3 13.2 5 6.1 1.2 3.4 2 1 1 3 3 3 0 Autophagy protein Apg17 FPP PF05911.11 ACS99214.1 - 2.3 6.3 16.1 10 4.1 16.1 1.8 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil CheZ PF04344.13 ACS99214.1 - 2.6 7.9 14.8 1.4 8.8 1.4 3.3 2 1 0 2 2 2 0 Chemotaxis phosphatase, CheZ BORCS7 PF16088.5 ACS99214.1 - 5.8 7.2 20.8 2.3 8.5 2.3 4.3 2 2 3 5 5 5 0 BLOC-1-related complex sub-unit 7 DUF1304 PF06993.12 ACS99215.1 - 3.8e-46 155.6 6.2 4.5e-46 155.4 6.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1304) KcnmB2_inactiv PF09303.10 ACS99215.1 - 0.076 12.8 0.0 0.58 10.0 0.1 2.1 2 0 0 2 2 2 0 KCNMB2, ball and chain domain SLH PF00395.20 ACS99216.1 - 3.1e-34 116.7 1.3 2.5e-15 56.2 0.0 4.8 5 0 0 5 5 5 3 S-layer homology domain fn3 PF00041.21 ACS99216.1 - 1.8e-07 31.4 7.2 0.033 14.5 1.9 4.0 3 0 0 3 3 3 3 Fibronectin type III domain DUF4992 PF16383.5 ACS99216.1 - 0.066 12.7 0.2 0.4 10.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF1093 PF06486.11 ACS99216.1 - 0.51 11.1 5.2 11 6.8 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1093) GerE PF00196.19 ACS99217.1 - 2.9e-16 58.7 0.5 4.9e-16 58.0 0.5 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family AAA_16 PF13191.6 ACS99217.1 - 1.2e-10 42.0 0.1 4.5e-09 36.9 0.0 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ACS99217.1 - 5.9e-08 33.1 0.0 1.8e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain Sigma70_r4_2 PF08281.12 ACS99217.1 - 9e-05 22.1 0.8 0.00031 20.3 0.8 2.0 1 0 0 1 1 1 1 Sigma-70, region 4 NB-ARC PF00931.22 ACS99217.1 - 0.0014 17.9 0.0 0.015 14.5 0.0 2.6 3 0 0 3 3 3 1 NB-ARC domain NACHT PF05729.12 ACS99217.1 - 0.0041 17.1 0.0 0.011 15.7 0.0 1.8 1 0 0 1 1 1 1 NACHT domain TniB PF05621.11 ACS99217.1 - 0.026 13.9 0.0 0.049 13.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein ATPase_2 PF01637.18 ACS99217.1 - 0.029 14.3 0.0 0.074 13.0 0.0 1.8 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Sigma70_r4 PF04545.16 ACS99217.1 - 0.052 13.1 1.9 0.22 11.0 1.3 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 RP-C PF03428.13 ACS99217.1 - 0.059 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Replication protein C N-terminal domain Sigma54_activat PF00158.26 ACS99217.1 - 0.18 11.5 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Glycos_transf_4 PF00953.21 ACS99218.1 - 3.1e-37 128.0 14.8 3.1e-37 128.0 14.8 2.9 3 0 0 3 3 3 1 Glycosyl transferase family 4 YtpI PF14007.6 ACS99218.1 - 0.024 14.8 4.7 3.4 7.9 0.0 3.7 2 1 1 3 3 3 0 YtpI-like protein DeoRC PF00455.22 ACS99219.1 - 3.9e-48 163.4 0.0 4.8e-48 163.1 0.0 1.1 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 ACS99219.1 - 1.5e-19 69.4 0.1 3.2e-19 68.4 0.1 1.6 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACS99219.1 - 6.9e-07 29.1 0.8 1.5e-06 28.0 0.0 1.9 2 0 0 2 2 2 1 HTH domain GntR PF00392.21 ACS99219.1 - 0.00083 19.0 0.0 0.0018 17.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family FaeA PF04703.12 ACS99219.1 - 0.0012 19.1 0.0 0.0026 18.1 0.0 1.6 1 0 0 1 1 1 1 FaeA-like protein HTH_12 PF08461.10 ACS99219.1 - 0.059 13.3 0.0 0.19 11.7 0.0 1.9 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain RepL PF05732.11 ACS99219.1 - 0.063 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) Mga PF05043.13 ACS99219.1 - 0.07 13.7 0.8 0.22 12.1 0.1 2.0 2 0 0 2 2 2 0 Mga helix-turn-helix domain Rrf2 PF02082.20 ACS99219.1 - 0.073 13.4 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator MarR PF01047.22 ACS99219.1 - 0.092 12.7 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 MarR family DUF2250 PF10007.9 ACS99219.1 - 0.11 12.7 0.1 0.52 10.5 0.0 2.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2250) EamA PF00892.20 ACS99220.1 - 6.6e-11 42.5 29.0 5.2e-07 29.9 8.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family Multi_Drug_Res PF00893.19 ACS99220.1 - 1.5e-05 25.6 0.6 1.5e-05 25.6 0.6 3.3 3 1 1 4 4 4 1 Small Multidrug Resistance protein DUF2545 PF10810.8 ACS99220.1 - 0.047 13.8 7.3 0.15 12.2 3.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2545) Metallophos PF00149.28 ACS99221.1 - 9.4e-13 49.1 4.1 1.5e-12 48.5 4.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACS99221.1 - 2.7e-07 30.9 0.8 4.6e-07 30.2 0.8 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF1529 PF07485.11 ACS99222.1 - 7.3e-35 119.5 0.0 8.9e-35 119.2 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1259) DUF1529 PF07485.11 ACS99223.1 - 2.6e-35 121.0 0.0 3.2e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1259) EamA PF00892.20 ACS99224.1 - 1.9e-40 138.2 42.4 4.9e-21 75.3 14.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 ACS99224.1 - 0.023 14.0 20.4 0.033 13.5 20.4 1.3 1 0 0 1 1 1 0 Triose-phosphate Transporter family Aminotran_1_2 PF00155.21 ACS99225.1 - 5.2e-23 81.8 0.0 8.2e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II GntR PF00392.21 ACS99225.1 - 1.1e-12 47.4 0.0 4.3e-12 45.5 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Aminotran_MocR PF12897.7 ACS99225.1 - 7.8e-05 21.6 0.0 0.00012 21.0 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase HTH_11 PF08279.12 ACS99225.1 - 0.14 12.1 0.1 0.67 9.9 0.0 2.2 3 0 0 3 3 3 0 HTH domain HTH_36 PF13730.6 ACS99225.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_18 PF12833.7 ACS99226.1 - 4.2e-24 84.6 0.6 1.7e-23 82.7 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99226.1 - 4.3e-15 55.4 0.9 1.2e-09 38.0 0.0 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99226.1 - 7.7e-06 25.9 0.0 2e-05 24.5 0.0 1.8 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99226.1 - 1.9e-05 24.3 0.0 4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Cupin domain EutQ PF06249.12 ACS99226.1 - 0.002 17.9 0.0 0.0056 16.4 0.0 1.7 1 1 1 2 2 2 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.12 ACS99226.1 - 0.077 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Sulfatase PF00884.23 ACS99227.1 - 2.4e-50 171.7 0.0 4.9e-50 170.7 0.0 1.5 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACS99227.1 - 2.8e-10 40.3 0.2 1.4e-09 38.0 0.2 2.0 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 ACS99227.1 - 0.00057 18.6 0.0 0.00078 18.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF4994 PF16385.5 ACS99227.1 - 0.0071 16.2 0.0 0.11 12.4 0.0 2.3 1 1 0 1 1 1 1 Domain of unknown function Metalloenzyme PF01676.18 ACS99227.1 - 0.073 12.4 0.0 0.13 11.6 0.0 1.4 1 1 0 1 1 1 0 Metalloenzyme superfamily Phage_Arf PF17585.2 ACS99227.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Accessory recombination function protein MS_channel PF00924.18 ACS99228.1 - 3.4e-48 163.9 6.3 3e-47 160.8 0.5 3.2 2 1 0 2 2 2 1 Mechanosensitive ion channel SPC25 PF06703.11 ACS99228.1 - 0.55 10.0 8.0 0.085 12.6 2.1 2.1 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Acetyltransf_3 PF13302.7 ACS99229.1 - 1e-21 78.1 0.0 1.2e-21 77.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACS99229.1 - 0.0031 17.8 0.0 0.0041 17.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 ACS99229.1 - 0.11 12.2 0.0 0.14 11.8 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain MR_MLE_C PF13378.6 ACS99230.1 - 4.2e-34 118.0 0.1 5.9e-34 117.5 0.1 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like Smr PF01713.21 ACS99230.1 - 0.057 13.8 0.4 0.25 11.7 0.3 2.1 2 1 0 2 2 2 0 Smr domain Abhydrolase_3 PF07859.13 ACS99231.1 - 5.7e-67 225.6 0.9 7.2e-67 225.3 0.9 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ACS99231.1 - 9e-12 44.6 0.3 1.5e-10 40.6 0.3 2.0 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.7 ACS99231.1 - 4.5e-05 24.2 2.9 6.8e-05 23.6 2.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ACS99231.1 - 6.3e-05 22.5 0.0 8.6e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 ACS99231.1 - 0.00042 19.3 0.0 0.00059 18.8 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_1 PF00561.20 ACS99231.1 - 0.00067 19.4 0.2 0.0017 18.0 0.2 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.12 ACS99231.1 - 0.034 12.8 0.2 0.15 10.7 0.1 1.9 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 ACS99231.1 - 0.047 12.9 1.2 0.38 10.0 0.7 2.4 1 1 0 2 2 2 0 Serine aminopeptidase, S33 Say1_Mug180 PF10340.9 ACS99231.1 - 0.062 12.2 0.0 0.089 11.6 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Esterase_phd PF10503.9 ACS99231.1 - 0.082 12.4 1.0 0.27 10.7 0.2 2.1 2 0 0 2 2 2 0 Esterase PHB depolymerase Chlorophyllase PF07224.11 ACS99231.1 - 0.11 11.6 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase HxlR PF01638.17 ACS99232.1 - 3e-28 97.5 0.1 3.9e-28 97.1 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.14 ACS99232.1 - 0.0013 18.7 0.2 0.0021 18.0 0.2 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family MarR PF01047.22 ACS99232.1 - 0.0022 17.9 0.1 0.0035 17.2 0.1 1.4 1 0 0 1 1 1 1 MarR family Uds1 PF15456.6 ACS99232.1 - 0.026 14.7 0.1 0.036 14.2 0.1 1.2 1 0 0 1 1 1 0 Up-regulated During Septation HTH_20 PF12840.7 ACS99232.1 - 0.077 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain YqgC PF17430.2 ACS99232.1 - 0.2 11.8 1.1 0.86 9.7 0.5 2.0 2 0 0 2 2 2 0 Uncharacterized YqgC-like WYL PF13280.6 ACS99233.1 - 9e-33 113.7 0.0 1.2e-32 113.4 0.0 1.1 1 0 0 1 1 1 1 WYL domain HTH_11 PF08279.12 ACS99233.1 - 3.5e-11 42.9 0.0 6.2e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 HTH domain HTH_DeoR PF08220.12 ACS99233.1 - 0.001 18.8 0.0 0.0036 17.0 0.0 1.9 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain PuR_N PF09182.10 ACS99233.1 - 0.0087 16.0 0.1 0.031 14.2 0.0 2.0 2 0 0 2 2 2 1 Bacterial purine repressor, N-terminal HTH_28 PF13518.6 ACS99233.1 - 0.016 15.3 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_7 PF02796.15 ACS99233.1 - 0.042 13.9 0.0 0.084 13.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase DinB PF05163.12 ACS99234.1 - 8.4e-30 103.9 0.1 1.3e-29 103.3 0.1 1.2 1 1 0 1 1 1 1 DinB family DinB_2 PF12867.7 ACS99234.1 - 3.6e-08 34.0 0.1 5e-08 33.5 0.1 1.1 1 0 0 1 1 1 1 DinB superfamily DUF664 PF04978.12 ACS99234.1 - 0.00026 21.4 0.0 0.00053 20.4 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF664) ADH_zinc_N_2 PF13602.6 ACS99235.1 - 3.7e-26 92.7 0.0 5.6e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ACS99235.1 - 2.8e-14 53.2 0.0 6.1e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ACS99235.1 - 2.8e-07 30.4 0.0 7e-06 25.9 0.0 2.7 2 2 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ELFV_dehydrog PF00208.21 ACS99235.1 - 0.048 13.4 0.1 0.073 12.8 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Pyr_redox PF00070.27 ACS99235.1 - 0.11 13.1 0.0 0.29 11.7 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Peripla_BP_5 PF13433.6 ACS99236.1 - 7.8e-166 551.5 0.3 9.2e-166 551.3 0.3 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_6 PF13458.6 ACS99236.1 - 2e-88 297.4 2.5 2.3e-88 297.1 2.5 1.0 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.28 ACS99236.1 - 2e-10 40.4 0.0 2.7e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Glyco_tran_WecB PF03808.13 ACS99236.1 - 0.016 15.2 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family BPD_transp_2 PF02653.16 ACS99237.1 - 4.7e-53 180.1 34.6 5.3e-53 179.9 34.6 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component BPD_transp_2 PF02653.16 ACS99238.1 - 8.4e-44 149.7 35.3 1.3e-43 149.1 35.3 1.3 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component DUF2070 PF09843.9 ACS99238.1 - 7.6 4.7 18.2 0.074 11.3 6.2 2.3 2 1 0 2 2 2 0 Predicted membrane protein (DUF2070) ABC_tran PF00005.27 ACS99239.1 - 1.4e-29 103.4 0.0 2.2e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS99239.1 - 9.4e-07 28.9 0.1 0.0093 15.8 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS99239.1 - 7.4e-06 25.6 0.1 1.4e-05 24.6 0.1 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ACS99239.1 - 0.00015 22.4 0.4 0.00028 21.4 0.4 1.7 1 1 0 1 1 1 1 AAA domain BCA_ABC_TP_C PF12399.8 ACS99239.1 - 0.00015 21.6 0.1 0.00028 20.7 0.1 1.4 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_15 PF13175.6 ACS99239.1 - 0.00031 20.6 0.0 0.00039 20.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACS99239.1 - 0.00034 20.3 0.1 0.00059 19.5 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ACS99239.1 - 0.011 15.5 1.5 0.059 13.1 1.5 2.0 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACS99239.1 - 0.014 15.4 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA PF00004.29 ACS99239.1 - 0.015 15.7 1.3 0.035 14.5 0.4 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Gtr1_RagA PF04670.12 ACS99239.1 - 0.022 14.1 0.0 0.046 13.1 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF2813 PF11398.8 ACS99239.1 - 0.024 13.9 0.0 0.034 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) AAA_27 PF13514.6 ACS99239.1 - 0.036 13.7 0.0 0.07 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.6 ACS99239.1 - 0.05 12.2 0.0 0.064 11.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 ACS99239.1 - 0.066 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_25 PF13481.6 ACS99239.1 - 0.078 12.6 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ACS99239.1 - 0.097 12.7 0.3 1.5 8.8 0.0 2.4 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Ribosomal_L11 PF00298.19 ACS99239.1 - 0.11 13.0 0.0 0.29 11.7 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L11, RNA binding domain ABC_tran PF00005.27 ACS99240.1 - 1.5e-32 113.0 0.0 2e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS99240.1 - 4.6e-09 36.5 0.0 0.00073 19.4 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACS99240.1 - 3.5e-05 23.5 0.0 6.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.12 ACS99240.1 - 0.00014 21.8 0.2 0.00026 20.9 0.2 1.4 1 0 0 1 1 1 1 NACHT domain AAA PF00004.29 ACS99240.1 - 0.00036 21.0 0.2 0.0017 18.7 0.2 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ACS99240.1 - 0.0016 18.2 1.2 0.0022 17.7 1.2 1.5 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACS99240.1 - 0.0024 17.8 0.1 0.0038 17.2 0.1 1.2 1 0 0 1 1 1 1 RsgA GTPase MobB PF03205.14 ACS99240.1 - 0.0025 17.7 0.1 0.0047 16.8 0.1 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.22 ACS99240.1 - 0.004 16.4 0.1 0.0077 15.4 0.1 1.5 1 0 0 1 1 1 1 NB-ARC domain ATPase_2 PF01637.18 ACS99240.1 - 0.0042 17.0 0.1 0.012 15.6 0.0 1.6 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_23 PF13476.6 ACS99240.1 - 0.005 17.4 0.0 0.0075 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACS99240.1 - 0.0059 17.0 0.1 0.0096 16.3 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ACS99240.1 - 0.0066 16.5 0.3 0.013 15.5 0.3 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 ACS99240.1 - 0.008 16.1 0.3 0.032 14.1 0.1 1.9 2 0 0 2 2 2 1 NTPase AAA_22 PF13401.6 ACS99240.1 - 0.0096 16.2 0.1 0.018 15.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 ACS99240.1 - 0.011 15.4 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 ACS99240.1 - 0.017 15.2 0.1 0.028 14.4 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 ACS99240.1 - 0.026 14.8 0.4 0.05 13.9 0.4 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACS99240.1 - 0.031 14.4 0.1 0.062 13.4 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Roc PF08477.13 ACS99240.1 - 0.034 14.3 0.1 0.079 13.2 0.1 1.6 2 0 0 2 2 1 0 Ras of Complex, Roc, domain of DAPkinase SMC_N PF02463.19 ACS99240.1 - 0.038 13.4 0.0 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain DLIC PF05783.11 ACS99240.1 - 0.055 12.3 0.1 0.076 11.8 0.1 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) ATP-synt_ab PF00006.25 ACS99240.1 - 0.067 12.8 0.0 0.082 12.6 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.6 ACS99240.1 - 0.081 12.6 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ACS99240.1 - 0.087 12.3 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region DnaB_C PF03796.15 ACS99240.1 - 0.093 12.1 0.0 0.47 9.7 0.0 1.9 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain RNA_helicase PF00910.22 ACS99240.1 - 0.11 13.0 0.1 0.19 12.1 0.1 1.4 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 ACS99240.1 - 0.11 12.5 0.1 0.62 10.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 ACS99240.1 - 0.11 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Diphthami_syn_2 PF01902.17 ACS99241.1 - 7e-46 156.5 0.0 7.8e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 Diphthamide synthase ThiI PF02568.14 ACS99241.1 - 0.19 11.3 0.1 1.4 8.5 0.0 2.0 1 1 1 2 2 2 0 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 ACS99241.1 - 0.25 10.8 0.0 4.1 6.8 0.0 2.2 1 1 1 2 2 2 0 Queuosine biosynthesis protein QueC BPD_transp_1 PF00528.22 ACS99242.1 - 4.4e-21 75.4 19.3 4.4e-21 75.4 19.3 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99243.1 - 3.3e-10 40.0 40.0 4.5e-10 39.6 30.9 2.9 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component TM_PBP2_N PF16296.5 ACS99243.1 - 0.22 11.7 1.3 0.57 10.4 1.3 1.7 1 0 0 1 1 1 0 N-terminal of TM subunit in PBP-dependent ABC transporters SBP_bac_8 PF13416.6 ACS99244.1 - 9.9e-53 179.8 9.6 1.2e-52 179.5 9.6 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACS99244.1 - 8.6e-50 170.5 10.8 1.2e-49 169.9 10.8 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACS99244.1 - 5.3e-06 26.0 2.9 0.025 14.0 0.3 2.3 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACS99244.1 - 0.00011 22.1 0.0 0.029 14.1 0.0 2.3 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein AhpC-TSA PF00578.21 ACS99244.1 - 0.12 12.3 0.0 0.51 10.3 0.0 2.1 1 0 0 1 1 1 0 AhpC/TSA family S1_2 PF13509.6 ACS99244.1 - 0.12 12.4 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 S1 domain Glyco_hydro_36 PF17167.4 ACS99245.1 - 8.3e-10 37.9 0.1 1.4e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain Glyco_hydro_65C PF03633.15 ACS99245.1 - 0.011 15.7 0.2 0.48 10.4 0.0 3.3 3 0 0 3 3 3 0 Glycosyl hydrolase family 65, C-terminal domain Peripla_BP_3 PF13377.6 ACS99246.1 - 6.9e-22 78.5 0.0 1.3e-21 77.6 0.0 1.5 1 0 0 1 1 1 1 Periplasmic binding protein-like domain LacI PF00356.21 ACS99246.1 - 2.1e-19 69.1 0.5 3.5e-19 68.3 0.5 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACS99246.1 - 2.4e-15 56.8 0.0 3.1e-14 53.2 0.0 2.3 3 0 0 3 3 3 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACS99246.1 - 2.6e-14 53.3 0.0 3.9e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family HTH_10 PF04967.12 ACS99246.1 - 0.0012 18.6 0.3 0.077 12.8 0.0 2.4 2 0 0 2 2 2 1 HTH DNA binding domain HTH_24 PF13412.6 ACS99246.1 - 0.021 14.3 0.3 0.069 12.7 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_31 PF13560.6 ACS99246.1 - 0.028 14.8 0.0 0.13 12.6 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain TetR_N PF00440.23 ACS99246.1 - 0.034 14.0 0.4 0.22 11.3 0.1 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family HTH_3 PF01381.22 ACS99246.1 - 0.038 14.0 0.0 0.075 13.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix HTH_38 PF13936.6 ACS99246.1 - 0.13 12.1 1.4 0.37 10.6 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 ACS99246.1 - 0.14 11.6 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 YcxB PF14317.6 ACS99247.1 - 8.1e-12 44.7 0.0 1.6e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 YcxB-like protein DUF3784 PF12650.7 ACS99247.1 - 0.027 14.7 6.1 0.89 9.8 2.5 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) DUF3890 PF13029.6 ACS99247.1 - 0.034 14.6 2.1 0.065 13.7 2.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3890) BatA PF07584.11 ACS99247.1 - 0.38 11.1 0.0 0.38 11.1 0.0 3.1 2 1 1 3 3 3 0 Aerotolerance regulator N-terminal DUF155 PF02582.14 ACS99248.1 - 3.4e-25 89.1 1.4 4.6e-25 88.7 1.4 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 FH2 PF02181.23 ACS99248.1 - 0.05 12.7 0.3 0.11 11.6 0.0 1.6 2 0 0 2 2 2 0 Formin Homology 2 Domain THDPS_N_2 PF14805.6 ACS99248.1 - 0.14 12.4 0.1 0.26 11.5 0.1 1.4 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal DUF601 PF04642.12 ACS99248.1 - 0.21 11.1 0.0 0.28 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF601 2OG-FeII_Oxy_3 PF13640.6 ACS99249.1 - 1.3e-19 70.9 0.3 2.3e-19 70.1 0.2 1.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ACS99249.1 - 2.4e-06 28.0 0.1 4.6e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 ACS99249.1 - 0.0021 17.2 0.0 0.0023 17.1 0.0 1.2 1 0 0 1 1 1 1 Poxvirus C4/C10 protein SWM_repeat PF13753.6 ACS99250.1 - 0.00011 22.2 0.1 0.0035 17.4 0.1 2.1 1 1 0 1 1 1 1 Putative flagellar system-associated repeat ABC_tran PF00005.27 ACS99251.1 - 6.9e-47 159.4 0.7 3.9e-25 88.9 0.1 3.2 3 1 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 ACS99251.1 - 2.6e-22 78.6 6.9 5e-22 77.7 6.9 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS99251.1 - 6e-16 59.1 0.6 0.014 15.2 0.0 4.5 4 1 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS99251.1 - 9.6e-13 48.1 0.9 0.0014 18.1 0.0 4.2 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ACS99251.1 - 8.1e-09 35.6 0.0 0.0023 18.0 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_28 PF13521.6 ACS99251.1 - 2.1e-08 34.6 0.3 0.00038 20.7 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 ACS99251.1 - 1.6e-07 30.9 1.3 0.012 15.3 0.0 3.0 3 0 0 3 3 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACS99251.1 - 5.6e-07 29.6 0.0 0.022 14.7 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 ACS99251.1 - 9.5e-07 29.2 0.5 0.22 11.8 0.0 3.6 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ACS99251.1 - 3.2e-06 27.7 0.7 0.077 13.5 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ACS99251.1 - 4.3e-06 27.2 0.0 0.0044 17.4 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 ACS99251.1 - 4.2e-05 23.3 2.0 0.42 10.3 0.0 4.1 4 1 0 4 4 4 1 AAA domain AAA_23 PF13476.6 ACS99251.1 - 6.1e-05 23.6 9.3 0.13 12.7 0.1 3.4 3 0 0 3 3 3 2 AAA domain AAA_7 PF12775.7 ACS99251.1 - 0.00024 20.7 0.2 0.75 9.3 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region RNA_helicase PF00910.22 ACS99251.1 - 0.00028 21.2 2.6 0.12 12.8 0.0 3.6 3 1 0 3 3 3 1 RNA helicase AAA PF00004.29 ACS99251.1 - 0.00036 20.9 0.3 0.093 13.2 0.0 2.9 2 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 ACS99251.1 - 0.00053 19.2 0.7 0.19 10.9 0.1 2.7 2 1 0 2 2 2 1 NB-ARC domain AAA_14 PF13173.6 ACS99251.1 - 0.00065 19.7 0.2 5 7.2 0.0 4.1 4 1 0 4 4 4 0 AAA domain MeaB PF03308.16 ACS99251.1 - 0.00068 18.7 2.3 0.17 10.9 0.0 2.7 3 0 0 3 3 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 ACS99251.1 - 0.00074 19.7 5.0 0.064 13.3 0.1 3.2 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_33 PF13671.6 ACS99251.1 - 0.0015 18.7 0.3 2.3 8.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 ACS99251.1 - 0.0015 18.3 0.0 2.6 7.7 0.0 2.9 2 0 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 ACS99251.1 - 0.0017 17.7 0.1 1.5 8.2 0.0 3.2 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Roc PF08477.13 ACS99251.1 - 0.0019 18.4 0.0 0.93 9.7 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 ACS99251.1 - 0.0023 17.6 0.1 3.1 7.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain FeoB_N PF02421.18 ACS99251.1 - 0.0032 17.0 0.8 0.64 9.5 0.1 2.6 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_30 PF13604.6 ACS99251.1 - 0.0034 17.1 1.3 0.96 9.1 0.4 3.2 2 1 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.25 ACS99251.1 - 0.0038 16.9 0.2 3.1 7.4 0.1 2.3 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain SbcCD_C PF13558.6 ACS99251.1 - 0.004 17.3 0.0 3.7 7.9 0.0 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 ACS99251.1 - 0.0046 16.7 7.5 1.1 8.9 0.3 3.0 2 1 0 2 2 2 2 AAA ATPase domain NACHT PF05729.12 ACS99251.1 - 0.0048 16.8 1.9 0.93 9.4 0.2 2.6 2 0 0 2 2 2 1 NACHT domain TrwB_AAD_bind PF10412.9 ACS99251.1 - 0.0058 15.6 0.3 0.64 8.9 0.2 2.4 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.23 ACS99251.1 - 0.0071 16.4 5.8 0.67 10.0 0.1 3.5 3 1 1 4 4 3 1 Dynamin family MukB PF04310.12 ACS99251.1 - 0.0084 15.9 0.2 1.3 8.8 0.0 3.1 3 0 0 3 3 3 1 MukB N-terminal NTPase_1 PF03266.15 ACS99251.1 - 0.0089 16.0 0.9 3.1 7.7 0.1 2.6 2 0 0 2 2 2 1 NTPase Septin PF00735.18 ACS99251.1 - 0.0092 15.3 0.5 1.1 8.5 0.0 2.4 2 0 0 2 2 2 1 Septin Ploopntkinase3 PF18751.1 ACS99251.1 - 0.011 15.7 0.2 0.26 11.2 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_5 PF07728.14 ACS99251.1 - 0.019 14.9 0.4 5.1 7.1 0.1 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) TCL1_MTCP1 PF01840.17 ACS99251.1 - 0.02 14.5 0.3 0.49 10.1 0.0 2.3 2 0 0 2 2 2 0 TCL1/MTCP1 family MobB PF03205.14 ACS99251.1 - 0.024 14.6 1.0 5.7 6.9 0.2 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.18 ACS99251.1 - 0.029 13.7 0.5 2.4 7.5 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_13 PF13166.6 ACS99251.1 - 0.052 12.2 4.6 1.3 7.6 0.1 2.7 3 0 0 3 3 3 0 AAA domain ABC_tran_CTD PF16326.5 ACS99251.1 - 0.061 13.6 2.0 0.23 11.7 2.0 2.0 1 0 0 1 1 1 0 ABC transporter C-terminal domain Collectrin PF16959.5 ACS99251.1 - 0.064 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Renal amino acid transporter T2SSE PF00437.20 ACS99251.1 - 0.068 12.2 0.1 11 5.0 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein SRP54 PF00448.22 ACS99251.1 - 0.093 12.4 1.2 9.7 5.8 0.1 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF815 PF05673.13 ACS99251.1 - 0.44 9.7 4.8 2.3 7.3 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF815) PduV-EutP PF10662.9 ACS99251.1 - 0.91 9.3 2.6 15 5.3 0.1 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 ACS99251.1 - 0.93 9.1 3.0 18 4.9 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Flavodoxin_5 PF12724.7 ACS99252.1 - 4.2e-18 66.0 0.0 5.1e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_3 PF12641.7 ACS99252.1 - 6.8e-07 29.1 0.0 8.4e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin domain GP70 PF17429.2 ACS99252.1 - 0.086 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Gene product 70 MarR PF01047.22 ACS99253.1 - 2.8e-16 59.2 0.0 5e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACS99253.1 - 5.8e-11 42.1 0.0 1e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACS99253.1 - 7.9e-07 29.5 0.0 1.7e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.6 ACS99253.1 - 8.9e-07 28.4 0.0 1.8e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.10 ACS99253.1 - 2.7e-05 23.9 0.0 4.9e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 ACS99253.1 - 0.00014 21.7 0.0 0.00025 20.9 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB TFIIE_alpha PF02002.17 ACS99253.1 - 0.00062 19.6 0.1 0.0087 15.9 0.0 2.1 1 1 1 2 2 2 1 TFIIE alpha subunit HTH_11 PF08279.12 ACS99253.1 - 0.00071 19.5 0.0 0.013 15.5 0.0 2.3 2 0 0 2 2 2 1 HTH domain Fe_dep_repress PF01325.19 ACS99253.1 - 0.0014 18.7 0.0 0.0075 16.4 0.0 2.0 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain HTH_Crp_2 PF13545.6 ACS99253.1 - 0.0032 17.4 0.1 0.0072 16.3 0.1 1.7 1 1 0 1 1 1 1 Crp-like helix-turn-helix domain DUF480 PF04337.12 ACS99253.1 - 0.0071 16.5 0.1 0.12 12.4 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function, DUF480 DUF4423 PF14394.6 ACS99253.1 - 0.0086 15.8 0.0 0.016 14.9 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4423) HTH_34 PF13601.6 ACS99253.1 - 0.012 15.8 0.0 0.033 14.4 0.0 1.7 2 1 0 2 2 2 0 Winged helix DNA-binding domain Penicillinase_R PF03965.16 ACS99253.1 - 0.013 15.9 0.1 0.031 14.6 0.1 1.7 1 1 0 1 1 1 0 Penicillinase repressor DprA_WH PF17782.1 ACS99253.1 - 0.014 15.5 0.0 0.041 14.0 0.0 1.7 1 0 0 1 1 1 0 DprA winged helix domain HTH_20 PF12840.7 ACS99253.1 - 0.018 15.1 0.0 0.05 13.7 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain B-block_TFIIIC PF04182.12 ACS99253.1 - 0.074 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC HTH_5 PF01022.20 ACS99253.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Wzy_C PF04932.15 ACS99255.1 - 0.0024 17.5 0.1 0.0024 17.5 0.1 4.2 3 1 1 4 4 4 1 O-Antigen ligase DUF4418 PF14387.6 ACS99255.1 - 3.3 7.9 8.5 0.64 10.2 0.9 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4418) DUF2334 PF10096.9 ACS99256.1 - 0.028 14.1 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_tranf_2_3 PF13641.6 ACS99257.1 - 2.9e-37 128.8 0.0 3.7e-37 128.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ACS99257.1 - 1.5e-27 96.5 0.0 2.1e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 ACS99257.1 - 2.2e-25 89.8 4.9 5e-25 88.6 4.9 1.7 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 ACS99257.1 - 7.9e-16 58.0 0.1 1.9e-15 56.7 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 ACS99257.1 - 1.7e-06 27.7 0.1 9.9e-06 25.2 0.1 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 ACS99257.1 - 5.7e-05 21.9 6.7 0.76 8.3 0.0 3.1 3 0 0 3 3 3 2 Chitin synthase ATG22 PF11700.8 ACS99257.1 - 0.011 14.5 5.7 0.015 13.9 5.7 1.2 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Glyco_tranf_2_4 PF13704.6 ACS99257.1 - 0.038 14.5 0.0 0.12 12.9 0.0 1.8 1 1 1 2 2 2 0 Glycosyl transferase family 2 Cellulose_synt PF03552.14 ACS99257.1 - 0.066 11.7 7.9 2.3 6.6 0.1 2.2 2 0 0 2 2 2 0 Cellulose synthase Tetraspanin PF00335.20 ACS99257.1 - 4.1 7.0 6.0 20 4.8 0.0 2.3 2 0 0 2 2 2 0 Tetraspanin family BcsB PF03170.13 ACS99258.1 - 2.2e-51 175.0 0.8 1.2e-48 165.9 1.9 3.8 1 1 1 2 2 2 2 Bacterial cellulose synthase subunit 2Fe-2S_thioredx PF01257.19 ACS99258.1 - 0.17 11.7 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin GGDEF PF00990.21 ACS99259.1 - 1.1e-08 35.0 0.0 1.5e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain MamL-1 PF09596.10 ACS99259.1 - 0.14 12.5 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 MamL-1 domain PDT PF00800.18 ACS99260.1 - 6.3e-55 185.8 0.0 7.9e-55 185.5 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 ACS99260.1 - 4e-06 26.5 0.0 9.1e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 ACT domain Flavodoxin_2 PF02525.17 ACS99261.1 - 4.5e-40 137.5 0.0 5.4e-40 137.2 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ACS99261.1 - 3.9e-11 42.9 0.0 5.3e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase MarR PF01047.22 ACS99262.1 - 9.4e-11 41.5 0.1 4e-10 39.5 0.0 1.8 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.7 ACS99262.1 - 3.1e-08 33.4 0.0 8.2e-08 32.0 0.0 1.7 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 ACS99262.1 - 7.1e-07 29.6 0.0 2.4e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_20 PF12840.7 ACS99262.1 - 2.7e-06 27.3 0.0 6e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain SMC_ScpB PF04079.16 ACS99262.1 - 9.5e-05 22.1 0.0 0.00016 21.3 0.0 1.4 1 0 0 1 1 1 1 Segregation and condensation complex subunit ScpB TrmB PF01978.19 ACS99262.1 - 0.00078 19.3 0.0 0.0021 17.9 0.0 1.7 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 ACS99262.1 - 0.0041 17.1 0.0 0.0062 16.5 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_34 PF13601.6 ACS99262.1 - 0.0053 16.9 0.0 0.014 15.6 0.0 1.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_5 PF01022.20 ACS99262.1 - 0.0094 15.8 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 ACS99262.1 - 0.06 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.10 ACS99262.1 - 0.064 13.1 0.0 0.26 11.1 0.0 1.9 2 0 0 2 2 2 0 IclR helix-turn-helix domain DinB_2 PF12867.7 ACS99262.1 - 0.076 13.5 0.1 0.13 12.8 0.1 1.6 1 1 0 1 1 1 0 DinB superfamily Rrf2 PF02082.20 ACS99262.1 - 0.13 12.6 0.0 0.31 11.4 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator Lactamase_B_2 PF12706.7 ACS99263.1 - 3.7e-44 150.7 0.1 5.3e-44 150.2 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ACS99263.1 - 3.7e-16 59.4 0.0 4.8e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACS99263.1 - 4.7e-05 23.5 1.0 0.00059 19.9 1.0 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Sulfatase PF00884.23 ACS99264.1 - 9.6e-47 159.9 0.0 1.9e-46 158.9 0.0 1.5 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACS99264.1 - 2.5e-06 27.3 0.8 0.049 13.2 0.1 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 ACS99264.1 - 0.0037 15.9 0.1 0.0075 14.9 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF229) DUF4976 PF16347.5 ACS99264.1 - 0.4 11.0 4.4 1.6 9.0 2.0 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4976) Na_H_Exchanger PF00999.21 ACS99266.1 - 4.9e-57 193.5 51.7 6.2e-57 193.1 51.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_C PF02080.21 ACS99267.1 - 8.8e-09 35.1 0.0 7.8e-08 32.0 0.0 2.1 2 0 0 2 2 2 1 TrkA-C domain Toprim_3 PF13362.6 ACS99267.1 - 0.042 14.2 0.6 0.2 12.0 0.1 2.2 2 1 0 2 2 2 0 Toprim domain DUF5316 PF17247.2 ACS99268.1 - 0.04 13.9 0.2 0.054 13.5 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5316) HPP PF04982.13 ACS99269.1 - 1.4e-35 122.2 11.6 1.4e-35 122.2 11.6 1.7 2 0 0 2 2 2 1 HPP family PRA1 PF03208.19 ACS99269.1 - 1 8.9 8.0 9.9 5.8 5.6 2.1 2 0 0 2 2 2 0 PRA1 family protein ABC_export PF16962.5 ACS99269.1 - 2.7 6.3 11.0 2.7 6.3 4.6 2.3 1 1 1 2 2 2 0 Putative ABC exporter LysR_substrate PF03466.20 ACS99270.1 - 7.9e-39 133.2 0.1 1.2e-38 132.6 0.1 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACS99270.1 - 9.4e-19 67.1 0.9 2.4e-18 65.9 0.1 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family adh_short_C2 PF13561.6 ACS99271.1 - 1.8e-64 217.5 5.1 2.2e-64 217.2 5.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACS99271.1 - 3.2e-54 183.4 5.2 3.8e-54 183.1 5.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACS99271.1 - 1.8e-15 57.3 2.9 2.4e-15 56.9 2.9 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACS99271.1 - 0.00065 19.2 1.2 0.0025 17.3 1.2 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 ACS99271.1 - 0.00073 20.1 2.3 0.0024 18.4 1.9 2.1 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent ADH_zinc_N PF00107.26 ACS99271.1 - 0.058 13.4 5.1 0.12 12.4 1.8 2.3 2 0 0 2 2 2 0 Zinc-binding dehydrogenase 3HCDH_N PF02737.18 ACS99271.1 - 0.062 13.2 1.0 0.11 12.4 1.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ACS99271.1 - 0.18 12.3 0.7 0.38 11.2 0.5 1.9 1 1 0 1 1 1 0 Putative NAD(P)-binding Glyco_tran_WecB PF03808.13 ACS99271.1 - 0.23 11.4 0.7 0.63 10.0 0.5 1.8 1 1 1 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family TetR_N PF00440.23 ACS99272.1 - 7.9e-11 41.6 0.0 1.9e-10 40.3 0.0 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.6 ACS99272.1 - 6e-06 26.5 0.0 8.2e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 BetI-type transcriptional repressor, C-terminal TetR_C_11 PF16859.5 ACS99272.1 - 2.3e-05 24.7 0.0 0.00017 21.9 0.0 2.0 1 1 1 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_C_13 PF16925.5 ACS99272.1 - 0.0005 20.0 0.0 0.0008 19.3 0.0 1.4 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_4 PF08359.11 ACS99272.1 - 0.0012 19.0 0.1 0.0082 16.3 0.0 2.1 1 1 0 2 2 2 1 YsiA-like protein, C-terminal region TetR_C_24 PF17932.1 ACS99272.1 - 0.0058 16.9 0.0 0.026 14.8 0.0 2.0 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 ACS99272.1 - 0.014 15.5 0.1 0.033 14.3 0.1 1.8 1 1 0 1 1 1 0 Helix-turn-helix of insertion element transposase PagP PF07017.11 ACS99272.1 - 0.098 12.1 0.1 0.14 11.6 0.1 1.2 1 0 0 1 1 1 0 Antimicrobial peptide resistance and lipid A acylation protein PagP Terminase_5 PF06056.12 ACS99272.1 - 0.12 12.3 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_28 PF13518.6 ACS99272.1 - 0.14 12.4 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain MarR PF01047.22 ACS99273.1 - 2.7e-11 43.2 0.0 5e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACS99273.1 - 6.6e-11 41.9 0.0 1.4e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACS99273.1 - 3.1e-09 37.2 0.1 6.2e-09 36.2 0.0 1.5 2 0 0 2 2 1 1 Winged helix DNA-binding domain HTH_24 PF13412.6 ACS99273.1 - 6.2e-06 25.7 0.3 3.7e-05 23.2 0.1 2.2 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding Fe_dep_repress PF01325.19 ACS99273.1 - 0.00013 22.1 0.0 0.0003 20.9 0.0 1.6 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_11 PF08279.12 ACS99273.1 - 0.0002 21.3 0.2 0.0095 15.9 0.0 2.9 3 0 0 3 3 3 1 HTH domain TrmB PF01978.19 ACS99273.1 - 0.0003 20.6 0.4 0.0014 18.5 0.1 2.3 2 1 1 3 3 3 1 Sugar-specific transcriptional regulator TrmB GntR PF00392.21 ACS99273.1 - 0.0049 16.5 0.0 0.012 15.2 0.0 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_34 PF13601.6 ACS99273.1 - 0.01 16.0 0.0 0.046 13.9 0.0 1.9 2 0 0 2 2 2 0 Winged helix DNA-binding domain Replic_Relax PF13814.6 ACS99273.1 - 0.012 15.7 0.2 0.015 15.3 0.2 1.2 1 0 0 1 1 1 0 Replication-relaxation HTH_IclR PF09339.10 ACS99273.1 - 0.013 15.2 0.1 0.05 13.4 0.0 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain HxlR PF01638.17 ACS99273.1 - 0.02 14.7 0.2 0.11 12.4 0.2 2.2 1 1 0 1 1 1 0 HxlR-like helix-turn-helix SMC_ScpB PF04079.16 ACS99273.1 - 0.03 14.0 0.1 0.041 13.5 0.1 1.2 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB HTH_36 PF13730.6 ACS99273.1 - 0.068 13.1 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_20 PF12840.7 ACS99273.1 - 0.077 13.1 0.2 3.6 7.7 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain TFIIE_alpha PF02002.17 ACS99273.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 TFIIE alpha subunit Rrf2 PF02082.20 ACS99273.1 - 0.084 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator Glyoxalase PF00903.25 ACS99274.1 - 0.0025 18.0 0.0 0.003 17.8 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily SLH PF00395.20 ACS99275.1 - 4e-19 68.4 2.9 3.2e-06 27.1 0.2 3.5 3 0 0 3 3 3 3 S-layer homology domain DUF637 PF04830.13 ACS99275.1 - 0.048 13.5 3.0 0.5 10.2 0.4 2.1 2 0 0 2 2 2 0 Possible hemagglutinin (DUF637) DUF908 PF06012.12 ACS99275.1 - 9.9 5.5 6.8 13 5.0 6.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SGL PF08450.12 ACS99276.1 - 7.4e-80 268.1 0.1 1e-79 267.6 0.1 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 ACS99276.1 - 0.0058 16.7 0.4 4.9 7.7 0.2 3.6 3 0 0 3 3 3 2 Two component regulator propeller Lactonase PF10282.9 ACS99276.1 - 0.21 10.8 0.0 0.4 9.9 0.0 1.4 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Hexapep PF00132.24 ACS99277.1 - 1.5e-10 40.4 6.1 0.0059 16.3 0.5 4.4 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACS99277.1 - 8.7 6.2 12.0 7.4 6.4 0.0 4.5 4 1 2 6 6 6 0 Hexapeptide repeat of succinyl-transferase SUR7 PF06687.12 ACS99278.1 - 0.0076 15.9 0.2 0.0076 15.9 0.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family Jiraiya PF15038.6 ACS99278.1 - 0.068 12.6 6.8 0.088 12.2 4.6 1.8 1 1 1 2 2 2 0 Jiraiya Radical_SAM PF04055.21 ACS99279.1 - 3.7e-21 76.2 0.0 3.7e-21 76.2 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.6 ACS99279.1 - 8.7e-09 35.5 0.0 8.7e-09 35.5 0.0 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 ACS99279.1 - 3.8e-06 27.2 0.2 8.5e-06 26.1 0.0 1.7 1 1 0 1 1 1 1 4Fe-4S single cluster domain LGT PF01790.18 ACS99280.1 - 8.8e-27 93.9 8.1 1.1e-26 93.6 8.1 1.1 1 0 0 1 1 1 1 Prolipoprotein diacylglyceryl transferase LrgB PF04172.16 ACS99280.1 - 0.027 14.0 0.0 3 7.3 0.0 2.4 2 0 0 2 2 2 0 LrgB-like family Rick_17kDa_Anti PF05433.15 ACS99280.1 - 0.25 11.3 10.9 0.73 9.7 0.5 2.6 3 0 0 3 3 3 0 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 ACS99280.1 - 0.38 10.8 7.8 3.5 7.7 0.1 2.8 3 0 0 3 3 3 0 Glycine zipper TauE PF01925.19 ACS99280.1 - 0.45 10.1 10.2 0.069 12.8 4.3 2.4 1 1 1 2 2 2 0 Sulfite exporter TauE/SafE adh_short_C2 PF13561.6 ACS99281.1 - 2.6e-52 177.7 1.8 3e-52 177.5 1.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACS99281.1 - 2.8e-47 160.7 2.2 3.3e-47 160.5 2.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACS99281.1 - 6.7e-09 35.9 1.1 9.4e-09 35.4 1.1 1.1 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 ACS99281.1 - 0.027 13.8 0.0 0.052 12.9 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 ACS99281.1 - 0.09 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) ATPgrasp_YheCD PF14398.6 ACS99281.1 - 0.12 11.5 0.1 1.4 8.1 0.1 2.0 2 0 0 2 2 2 0 YheC/D like ATP-grasp Peptidase_S15 PF02129.18 ACS99282.1 - 1.1e-60 205.6 1.3 1.6e-60 205.0 1.3 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 ACS99282.1 - 1.7e-44 152.4 0.0 2.6e-44 151.9 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S9 PF00326.21 ACS99282.1 - 0.0012 18.4 0.4 0.06 12.8 0.1 2.4 2 0 0 2 2 2 1 Prolyl oligopeptidase family AXE1 PF05448.12 ACS99282.1 - 0.059 12.0 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 ACS99282.1 - 0.14 11.4 0.0 0.48 9.7 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Kelch_3 PF13415.6 ACS99282.1 - 3.7 7.9 5.7 11 6.4 1.0 3.2 3 1 0 3 3 3 0 Galactose oxidase, central domain Peptidase_M19 PF01244.21 ACS99283.1 - 7e-77 258.7 0.0 8e-77 258.5 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Amidohydro_2 PF04909.14 ACS99283.1 - 0.0002 21.2 0.0 0.00033 20.6 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase OCD_Mu_crystall PF02423.15 ACS99284.1 - 1.6e-86 290.1 0.4 1.9e-86 289.9 0.4 1.0 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 ACS99284.1 - 2.5e-05 24.4 0.0 4.3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ACS99284.1 - 0.032 14.8 0.0 0.088 13.4 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GGDEF PF00990.21 ACS99285.1 - 8.6e-42 142.6 0.0 1.2e-41 142.2 0.0 1.2 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GGDEF_2 PF17853.1 ACS99285.1 - 0.015 15.5 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 GGDEF-like domain DUF3951 PF13131.6 ACS99285.1 - 0.065 13.4 0.0 0.065 13.4 0.0 3.5 5 0 0 5 5 5 0 Protein of unknown function (DUF3951) DUF1211 PF06736.11 ACS99285.1 - 0.16 12.5 3.6 8.2 7.0 0.8 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1211) DUF1772 PF08592.11 ACS99285.1 - 0.59 10.4 2.7 13 6.0 0.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) ApbE PF02424.15 ACS99287.1 - 4.5e-53 180.4 0.0 5.9e-53 180.0 0.0 1.1 1 0 0 1 1 1 1 ApbE family Ferric_reduct PF01794.19 ACS99288.1 - 9e-08 32.3 6.8 1.8e-07 31.3 6.8 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component CKS PF01111.19 ACS99288.1 - 0.018 15.3 0.0 0.26 11.6 0.0 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase regulatory subunit DUF2705 PF10920.8 ACS99288.1 - 0.028 13.7 0.4 0.056 12.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2705) Cytochrom_B561 PF03188.16 ACS99288.1 - 0.29 11.3 11.6 2.5 8.2 1.6 2.2 2 0 0 2 2 2 0 Eukaryotic cytochrome b561 Colicin_V PF02674.16 ACS99288.1 - 0.3 11.1 10.4 0.031 14.3 4.7 2.1 1 1 1 2 2 2 0 Colicin V production protein LysR_substrate PF03466.20 ACS99290.1 - 9.9e-41 139.4 0.0 1.6e-40 138.7 0.0 1.3 1 1 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACS99290.1 - 8e-21 73.8 0.0 1.7e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 ACS99290.1 - 0.00017 20.8 0.0 0.0031 16.7 0.0 2.4 2 0 0 2 2 2 1 PBP superfamily domain PBP_like_2 PF12849.7 ACS99290.1 - 0.00031 20.5 0.0 0.00052 19.8 0.0 1.4 1 0 0 1 1 1 1 PBP superfamily domain MarR_2 PF12802.7 ACS99290.1 - 0.011 15.6 0.0 0.024 14.5 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_30 PF13556.6 ACS99290.1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_20 PF12840.7 ACS99290.1 - 0.11 12.5 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain SBP_bac_11 PF13531.6 ACS99290.1 - 0.13 12.0 0.0 1 9.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein SBP_bac_3 PF00497.20 ACS99290.1 - 0.13 11.6 0.0 0.39 10.1 0.0 1.7 1 1 1 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 MarR PF01047.22 ACS99290.1 - 0.17 11.8 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 MarR family Adenylsucc_synt PF00709.21 ACS99291.1 - 2.1e-152 507.9 0.0 2.3e-152 507.8 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DUF5519 PF17648.1 ACS99292.1 - 2.7e-29 101.4 0.0 3.1e-29 101.2 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5519) YjbR PF04237.13 ACS99292.1 - 0.048 14.2 0.0 0.065 13.8 0.0 1.1 1 0 0 1 1 1 0 YjbR SspH PF08141.12 ACS99293.1 - 2.3e-25 88.5 0.5 3.1e-25 88.1 0.5 1.2 1 0 0 1 1 1 1 Small acid-soluble spore protein H family EamA PF00892.20 ACS99294.1 - 1e-37 129.3 23.3 2.8e-20 72.9 12.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family SPC12 PF06645.13 ACS99294.1 - 0.051 13.7 15.1 0.08 13.0 0.4 4.5 3 1 0 4 4 4 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Autoind_bind PF03472.15 ACS99294.1 - 0.2 11.1 0.0 0.39 10.2 0.0 1.4 1 0 0 1 1 1 0 Autoinducer binding domain TMEM234 PF10639.9 ACS99294.1 - 2.2 8.4 7.1 0.59 10.2 0.3 3.1 3 1 0 3 3 3 0 Putative transmembrane family 234 HD_4 PF13328.6 ACS99295.1 - 1.5e-25 89.7 0.0 2.2e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 HD domain HD PF01966.22 ACS99295.1 - 4.2e-06 27.0 0.0 8.8e-06 25.9 0.0 1.5 1 1 0 1 1 1 1 HD domain F5_F8_type_C PF00754.25 ACS99296.1 - 4.4e-28 97.9 28.7 1.8e-20 73.3 3.5 5.3 4 1 1 5 5 5 2 F5/8 type C domain CARDB PF07705.11 ACS99296.1 - 6.1e-28 97.1 45.5 4.6e-22 78.2 9.8 5.5 5 1 0 5 5 5 2 CARDB CBM_35 PF16990.5 ACS99296.1 - 2.2e-12 47.3 6.4 2.2e-12 47.3 6.4 5.1 5 0 0 5 5 5 1 Carbohydrate binding module (family 35) CBM_6 PF03422.15 ACS99296.1 - 3.7e-09 37.0 10.3 3.7e-09 37.0 10.3 7.6 4 3 1 7 7 7 2 Carbohydrate binding module (family 6) DUF5000 PF16391.5 ACS99296.1 - 0.00013 22.1 1.3 1.7 8.8 0.0 4.8 3 2 1 4 4 4 1 Domain of unknown function Trypan_PARP PF05887.11 ACS99296.1 - 0.0012 18.8 20.7 0.0033 17.4 20.7 1.7 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Filamin PF00630.19 ACS99296.1 - 0.22 12.4 5.3 6.6 7.6 1.0 4.7 3 1 0 3 3 3 0 Filamin/ABP280 repeat Asp_Glu_race PF01177.22 ACS99297.1 - 2.6e-22 79.8 0.0 3.4e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase PucR PF07905.11 ACS99297.1 - 0.11 12.8 0.0 0.32 11.3 0.0 1.7 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family TrkH PF02386.16 ACS99298.1 - 8.6e-58 196.0 29.4 1.2e-57 195.6 29.4 1.1 1 0 0 1 1 1 1 Cation transport protein Y_phosphatase3 PF13350.6 ACS99299.1 - 3.7e-66 223.4 0.1 5e-66 223.0 0.1 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family UPF0061 PF02696.14 ACS99300.1 - 1.8e-124 416.1 0.0 2.1e-124 415.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family HTH_3 PF01381.22 ACS99301.1 - 1.8e-08 34.3 0.2 2.4e-08 33.9 0.2 1.1 1 0 0 1 1 1 1 Helix-turn-helix HTH_26 PF13443.6 ACS99301.1 - 3.3e-05 24.2 0.1 3.8e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_19 PF12844.7 ACS99301.1 - 5.1e-05 23.2 0.2 7e-05 22.8 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ACS99301.1 - 0.00022 21.5 0.1 0.00027 21.2 0.1 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain Lipoprotein_Ltp PF07553.11 ACS99301.1 - 0.17 12.2 0.0 7.2 7.0 0.0 2.1 2 0 0 2 2 2 0 Host cell surface-exposed lipoprotein ABM PF03992.16 ACS99302.1 - 0.00029 20.9 0.2 0.00041 20.4 0.2 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase AHSA1 PF08327.11 ACS99303.1 - 1.2e-13 51.4 0.0 1.9e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ACS99303.1 - 1.7e-06 28.4 0.4 2.4e-06 27.9 0.0 1.4 2 0 0 2 2 2 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 ACS99303.1 - 0.004 17.3 0.0 0.0041 17.3 0.0 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Chromate_transp PF02417.15 ACS99304.1 - 3.1e-42 144.4 15.8 3.5e-42 144.2 15.8 1.0 1 0 0 1 1 1 1 Chromate transporter DUF3377 PF11857.8 ACS99304.1 - 0.071 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF3007 PF11460.8 ACS99304.1 - 0.16 12.3 4.6 0.33 11.2 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3007) Chromate_transp PF02417.15 ACS99305.1 - 9e-41 139.6 16.0 1e-40 139.4 16.0 1.0 1 0 0 1 1 1 1 Chromate transporter Phage_holin_3_6 PF07332.11 ACS99305.1 - 0.92 9.6 18.7 6.6e+02 0.4 18.7 2.7 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2613 PF11021.8 ACS99305.1 - 4.6 7.4 10.0 21 5.3 2.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) DUF3377 PF11857.8 ACS99305.1 - 7.2 6.6 7.1 2.1 8.3 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) ROK PF00480.20 ACS99306.1 - 5.1e-33 114.8 0.0 6e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 ROK family MarR PF01047.22 ACS99306.1 - 0.00037 20.4 0.0 0.00069 19.5 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACS99306.1 - 0.01 15.7 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 MarR family NHL PF01436.21 ACS99307.1 - 1.4e-07 31.2 5.4 0.23 11.6 0.2 6.8 6 1 0 6 6 6 3 NHL repeat Cytochrom_D1 PF02239.16 ACS99307.1 - 6e-05 21.7 2.8 0.011 14.3 0.1 3.5 1 1 1 4 4 4 2 Cytochrome D1 heme domain SGL PF08450.12 ACS99307.1 - 0.0032 17.1 0.3 12 5.4 0.0 3.4 3 0 0 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region ABC_tran PF00005.27 ACS99308.1 - 4.6e-27 95.2 0.0 8e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS99308.1 - 3.7e-11 43.4 1.7 2.2e-07 31.0 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 ACS99308.1 - 0.0024 18.3 0.7 0.11 12.9 0.7 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ACS99308.1 - 0.0067 16.2 0.0 0.0097 15.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 ACS99308.1 - 0.011 15.5 0.0 1.7 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 ACS99308.1 - 0.012 15.3 1.3 0.054 13.2 0.5 2.3 2 1 1 3 3 3 0 P-loop containing region of AAA domain DUF4162 PF13732.6 ACS99308.1 - 0.014 16.1 0.1 0.083 13.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) AAA_16 PF13191.6 ACS99308.1 - 0.047 14.1 0.0 0.091 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 ACS99308.1 - 0.051 14.1 0.3 0.086 13.3 0.3 1.6 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.19 ACS99308.1 - 0.088 12.2 0.9 1.3 8.4 0.9 2.2 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACS99308.1 - 0.1 12.9 0.1 0.34 11.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 ACS99308.1 - 0.14 11.2 0.2 0.24 10.3 0.2 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Rad17 PF03215.15 ACS99308.1 - 0.19 11.6 0.3 0.53 10.2 0.1 1.8 2 0 0 2 2 2 0 Rad17 P-loop domain ABC2_membrane_6 PF06182.11 ACS99309.1 - 6e-44 150.5 19.0 7.5e-44 150.2 19.0 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein Not1 PF04054.15 ACS99309.1 - 3.1 6.6 4.0 3.3 6.5 0.3 2.0 1 1 1 2 2 2 0 CCR4-Not complex component, Not1 ABC2_membrane_6 PF06182.11 ACS99310.1 - 2e-17 63.7 15.1 2.4e-17 63.5 15.1 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 ACS99310.1 - 0.00052 19.5 17.5 0.00052 19.5 17.5 1.8 1 1 1 2 2 2 1 ABC-2 type transporter YqhR PF11085.8 ACS99311.1 - 0.073 13.0 2.2 0.092 12.7 2.2 1.1 1 0 0 1 1 1 0 Conserved membrane protein YqhR 7TMR-DISM_7TM PF07695.11 ACS99311.1 - 0.078 12.9 4.8 0.09 12.7 4.8 1.1 1 0 0 1 1 1 0 7TM diverse intracellular signalling ABC2_membrane_3 PF12698.7 ACS99311.1 - 0.48 9.5 2.9 0.57 9.2 2.9 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4131 PF13567.6 ACS99311.1 - 6.2 6.4 6.2 2.6 7.7 3.5 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) NUDIX PF00293.28 ACS99312.1 - 6.5e-15 55.3 0.1 8.3e-15 55.0 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 ACS99312.1 - 0.21 11.1 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 Nucleotide hydrolase GSHPx PF00255.19 ACS99313.1 - 6e-34 115.9 0.1 9e-34 115.3 0.1 1.3 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 ACS99313.1 - 0.0004 20.3 0.0 0.0008 19.3 0.0 1.5 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 ACS99313.1 - 0.0054 16.5 0.0 0.16 11.7 0.0 2.2 2 0 0 2 2 2 1 Redoxin Glyco_hydro_25 PF01183.20 ACS99315.1 - 3e-43 148.1 0.7 3.9e-43 147.7 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 DJ-1_PfpI PF01965.24 ACS99316.1 - 3.2e-23 82.3 0.0 3.8e-23 82.1 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ACS99316.1 - 0.021 14.5 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 ThiJ/PfpI family-like GATase_3 PF07685.14 ACS99316.1 - 0.03 13.9 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 ACS99316.1 - 0.07 12.9 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Cass2 PF14526.6 ACS99317.1 - 1.9e-27 96.3 0.3 3.1e-27 95.5 0.3 1.4 1 0 0 1 1 1 1 Integron-associated effector binding protein GyrI-like PF06445.15 ACS99317.1 - 5e-20 72.4 0.4 7.1e-20 71.9 0.4 1.2 1 0 0 1 1 1 1 GyrI-like small molecule binding domain HTH_18 PF12833.7 ACS99317.1 - 3.8e-19 68.7 4.4 6.5e-19 68.0 3.7 1.8 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99317.1 - 2.4e-17 62.5 1.4 2e-09 37.3 0.1 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family PadR PF03551.14 ACS99318.1 - 6.6e-19 67.7 0.2 8.7e-19 67.3 0.2 1.2 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family DUF1495 PF07381.11 ACS99318.1 - 0.0031 17.3 0.1 0.0048 16.7 0.1 1.4 1 1 0 1 1 1 1 Winged helix DNA-binding domain (DUF1495) DUF505 PF04458.12 ACS99318.1 - 0.004 15.6 0.0 0.0042 15.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF505) HTH_45 PF14947.6 ACS99318.1 - 0.035 14.1 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix HTH_34 PF13601.6 ACS99318.1 - 0.078 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_27 PF13463.6 ACS99318.1 - 0.09 13.3 0.1 0.2 12.2 0.0 1.7 2 0 0 2 2 2 0 Winged helix DNA-binding domain Replic_Relax PF13814.6 ACS99318.1 - 0.14 12.2 0.0 0.16 12.0 0.0 1.1 1 0 0 1 1 1 0 Replication-relaxation DUF4364 PF14277.6 ACS99318.1 - 0.14 11.8 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) DUF2812 PF11193.8 ACS99319.1 - 1.2e-27 96.3 1.4 1.5e-27 96.0 1.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2812) PIG-P PF08510.12 ACS99319.1 - 0.14 12.1 0.7 0.26 11.2 0.7 1.5 1 0 0 1 1 1 0 PIG-P Aldo_ket_red PF00248.21 ACS99320.1 - 4.5e-67 226.3 0.0 5.1e-67 226.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family APH PF01636.23 ACS99321.1 - 8.1e-26 91.4 0.0 1e-25 91.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 ACS99321.1 - 4e-10 39.4 0.0 5.3e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Fructosamine kinase RIO1 PF01163.22 ACS99321.1 - 0.025 14.2 0.0 1.4 8.4 0.0 2.2 2 0 0 2 2 2 0 RIO1 family DUF1679 PF07914.11 ACS99321.1 - 0.045 12.6 0.0 0.31 9.9 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) Response_reg PF00072.24 ACS99322.1 - 1.9e-21 76.3 0.3 3.7e-21 75.4 0.3 1.5 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 ACS99322.1 - 6.1e-09 35.3 0.1 1.2e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_40 PF14493.6 ACS99322.1 - 0.024 15.1 0.4 0.089 13.3 0.1 2.0 1 1 1 2 2 2 0 Helix-turn-helix domain XFP_C PF09363.10 ACS99322.1 - 0.057 12.9 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 XFP C-terminal domain Mob_Pre PF01076.19 ACS99322.1 - 0.078 12.8 0.1 0.15 11.8 0.1 1.4 1 1 0 1 1 1 0 Plasmid recombination enzyme HTH_23 PF13384.6 ACS99322.1 - 0.089 12.6 0.1 0.22 11.4 0.1 1.7 1 0 0 1 1 1 0 Homeodomain-like domain PilI PF10623.9 ACS99322.1 - 0.11 12.7 0.3 1.1 9.4 0.0 2.7 4 0 0 4 4 4 0 Plasmid conjugative transfer protein PilI EF-G-binding_N PF07299.11 ACS99322.1 - 0.14 12.7 2.9 2.8 8.6 0.1 2.9 2 1 0 2 2 2 0 Elongation factor G-binding protein, N-terminal HTH_7 PF02796.15 ACS99322.1 - 0.18 11.9 0.4 0.92 9.6 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase HATPase_c PF02518.26 ACS99323.1 - 3.1e-18 66.3 0.0 5.3e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACS99323.1 - 0.00064 19.6 0.0 0.0018 18.1 0.0 1.7 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 ACS99323.1 - 0.18 11.7 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MpPF26 PF07666.11 ACS99323.1 - 1.3 9.2 19.3 0.035 14.2 3.2 3.0 2 1 1 3 3 3 0 M penetrans paralogue family 26 SBP_bac_1 PF01547.25 ACS99324.1 - 3.9e-35 122.3 11.2 9.5e-35 121.1 11.2 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACS99324.1 - 1.3e-32 113.8 8.2 1.7e-32 113.3 8.2 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACS99324.1 - 9.4e-05 21.9 3.3 0.0066 15.9 3.3 2.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACS99325.1 - 6.6e-23 81.4 14.9 6.6e-23 81.4 14.9 1.7 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99326.1 - 1.1e-22 80.6 8.8 1.1e-22 80.6 8.8 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Sulfatase PF00884.23 ACS99327.1 - 1.5e-62 211.8 0.0 1.8e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACS99327.1 - 7.7e-10 38.9 0.0 0.00068 19.3 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 ACS99327.1 - 0.0012 17.5 0.0 0.0026 16.4 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF229) DUF4976 PF16347.5 ACS99327.1 - 0.047 13.9 0.1 0.047 13.9 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4976) Glyco_hydro_88 PF07470.13 ACS99328.1 - 1.4e-41 142.8 1.0 1.6e-41 142.5 1.0 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 BES1_N PF05687.13 ACS99328.1 - 0.2 12.1 0.0 0.41 11.0 0.0 1.5 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal Acetyltransf_1 PF00583.25 ACS99329.1 - 3.4e-14 53.1 0.0 4.3e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACS99329.1 - 1.5e-09 38.1 0.2 2.1e-09 37.7 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACS99329.1 - 1.1e-08 35.1 0.0 1.2e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACS99329.1 - 4.2e-05 23.7 0.0 5e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACS99329.1 - 0.00024 21.2 0.0 0.0035 17.4 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACS99329.1 - 0.00062 19.8 0.0 0.001 19.1 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 ACS99329.1 - 0.0014 18.5 0.0 0.0021 18.0 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 ACS99330.1 - 2e-13 50.6 0.2 2.6e-13 50.2 0.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACS99330.1 - 8.4e-12 45.3 1.0 1.3e-11 44.8 1.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACS99330.1 - 1.7e-09 37.7 0.2 2.8e-09 37.0 0.2 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACS99330.1 - 0.0015 18.5 0.4 0.027 14.4 0.4 2.5 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ACS99330.1 - 0.003 17.6 0.1 0.0047 17.0 0.1 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 ACS99330.1 - 0.011 15.9 0.1 0.069 13.2 0.1 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_19 PF18015.1 ACS99330.1 - 0.011 15.9 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 ACS99330.1 - 0.098 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Aldo_ket_red PF00248.21 ACS99331.1 - 8.4e-53 179.5 0.0 1e-52 179.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family GFO_IDH_MocA PF01408.22 ACS99332.1 - 3.5e-29 102.0 0.3 2.1e-28 99.6 0.1 2.2 3 0 0 3 3 3 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACS99332.1 - 1.5e-06 28.2 0.0 3.1e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DUF5572 PF17733.1 ACS99332.1 - 0.055 13.3 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5572) F420_oxidored PF03807.17 ACS99332.1 - 0.08 13.5 0.1 0.19 12.4 0.1 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent HTH_18 PF12833.7 ACS99333.1 - 1.7e-23 82.7 0.3 3.5e-23 81.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99333.1 - 8.3e-18 64.0 0.0 6.6e-09 35.6 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99333.1 - 6.7e-11 42.2 2.2 2.2e-10 40.6 1.7 2.1 1 1 1 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99333.1 - 0.004 16.8 0.0 0.0065 16.2 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Glyoxalase PF00903.25 ACS99334.1 - 0.0049 17.1 0.1 0.019 15.2 0.1 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Peripla_BP_2 PF01497.18 ACS99335.1 - 3.3e-33 115.2 1.3 4.8e-33 114.7 0.4 1.6 2 0 0 2 2 2 1 Periplasmic binding protein Sporozoite_P67 PF05642.11 ACS99335.1 - 0.047 11.8 2.4 0.064 11.3 2.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ribosomal_60s PF00428.19 ACS99335.1 - 0.18 12.4 3.3 18 6.0 0.0 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein SspB PF04386.13 ACS99335.1 - 0.25 11.2 1.9 0.67 9.8 0.0 2.1 2 0 0 2 2 2 0 Stringent starvation protein B HTH_18 PF12833.7 ACS99336.1 - 1.5e-19 70.0 0.5 1.5e-19 70.0 0.5 2.5 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99336.1 - 8.1e-16 57.7 3.3 1e-07 31.9 0.0 3.2 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Peripla_BP_2 PF01497.18 ACS99336.1 - 1.8e-09 37.5 0.0 3.4e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein HTH_Crp_2 PF13545.6 ACS99336.1 - 0.0018 18.2 0.0 0.007 16.3 0.0 2.1 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain Cupin_2 PF07883.11 ACS99336.1 - 0.0019 17.9 0.0 0.0034 17.1 0.0 1.4 1 0 0 1 1 1 1 Cupin domain VAPB_antitox PF02697.14 ACS99336.1 - 0.049 14.4 0.1 0.46 11.3 0.1 2.4 2 0 0 2 2 2 0 Putative antitoxin CENP-C_C PF11699.8 ACS99336.1 - 0.097 12.9 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Mif2/CENP-C like WYL PF13280.6 ACS99337.1 - 5.8e-10 39.5 0.0 1.2e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 WYL domain HTH_11 PF08279.12 ACS99337.1 - 0.034 14.1 0.0 0.22 11.5 0.0 2.2 2 0 0 2 2 2 0 HTH domain Peptidase_C10 PF01640.17 ACS99338.1 - 0.15 12.3 0.2 0.31 11.4 0.2 1.5 1 0 0 1 1 1 0 Peptidase C10 family Dioxygenase_N PF04444.14 ACS99338.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus Peripla_BP_4 PF13407.6 ACS99340.1 - 6.2e-66 222.6 7.5 8.1e-66 222.2 7.5 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain DUF2797 PF10977.8 ACS99340.1 - 0.014 15.3 0.1 2.5 7.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2797) ABC_tran PF00005.27 ACS99341.1 - 4.3e-50 169.8 0.6 6.4e-29 101.2 0.2 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACS99341.1 - 4e-07 30.2 0.4 0.0058 16.5 0.1 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACS99341.1 - 3.8e-05 23.3 0.2 0.0043 16.8 0.1 3.7 4 0 0 4 4 4 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACS99341.1 - 4.6e-05 23.4 2.0 0.015 15.2 0.1 3.5 4 0 0 4 4 4 1 RsgA GTPase AAA_18 PF13238.6 ACS99341.1 - 0.00023 21.7 0.5 3 8.4 0.0 3.5 3 0 0 3 3 3 1 AAA domain TsaE PF02367.17 ACS99341.1 - 0.00053 20.0 0.3 3.7 7.6 0.0 3.3 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE SMC_N PF02463.19 ACS99341.1 - 0.0015 18.0 4.7 0.49 9.8 0.1 2.9 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACS99341.1 - 0.0017 18.8 0.1 7.7 6.9 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain SbcCD_C PF13558.6 ACS99341.1 - 0.0043 17.3 0.4 9.4 6.6 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit dNK PF01712.19 ACS99341.1 - 0.0085 16.0 0.5 8.3 6.2 0.0 3.0 3 0 0 3 3 3 1 Deoxynucleoside kinase ABC_ATPase PF09818.9 ACS99341.1 - 0.0088 14.9 0.7 6.4 5.5 0.5 3.3 4 1 0 4 4 4 2 Predicted ATPase of the ABC class AAA_23 PF13476.6 ACS99341.1 - 0.019 15.5 1.7 0.033 14.7 0.2 2.1 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ACS99341.1 - 0.024 14.2 0.0 1.5 8.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 ACS99341.1 - 0.05 13.3 0.4 0.15 11.8 0.4 1.9 1 1 1 2 2 2 0 AAA ATPase domain AAA_27 PF13514.6 ACS99341.1 - 0.056 13.0 0.2 0.14 11.8 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ACS99341.1 - 0.075 12.7 0.0 0.77 9.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 ACS99341.1 - 0.085 13.1 3.4 2.1 8.6 0.1 2.8 3 0 0 3 3 2 0 AAA domain MMR_HSR1 PF01926.23 ACS99341.1 - 0.09 12.9 0.1 1.5 9.0 0.0 2.7 3 0 0 3 3 3 0 50S ribosome-binding GTPase Sigma54_activat PF00158.26 ACS99341.1 - 0.1 12.3 1.2 5 6.8 0.0 3.1 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_17 PF13207.6 ACS99341.1 - 0.14 12.6 2.5 5.5 7.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 ACS99341.1 - 2.6 7.2 5.3 19 4.3 0.1 3.0 4 0 0 4 4 4 0 NB-ARC domain BPD_transp_2 PF02653.16 ACS99342.1 - 1.1e-48 165.7 48.3 5.2e-48 163.5 48.3 1.9 1 1 0 1 1 1 1 Branched-chain amino acid transport system / permease component Peripla_BP_4 PF13407.6 ACS99343.1 - 4.5e-58 196.8 1.1 6e-58 196.4 1.1 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACS99343.1 - 9.2e-06 25.3 0.0 1.2e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family ANF_receptor PF01094.28 ACS99343.1 - 0.0033 16.6 0.0 0.0039 16.3 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 ACS99343.1 - 0.014 15.1 0.2 0.02 14.6 0.2 1.2 1 0 0 1 1 1 0 Periplasmic binding protein ABC_sub_bind PF04392.12 ACS99343.1 - 0.032 13.5 1.6 0.085 12.1 0.8 2.0 1 1 1 2 2 2 0 ABC transporter substrate binding protein dCache_1 PF02743.18 ACS99344.1 - 3.4e-29 102.4 3.4 5.7e-29 101.6 3.4 1.3 1 0 0 1 1 1 1 Cache domain His_kinase PF06580.13 ACS99344.1 - 2.4e-27 95.1 0.5 9.6e-27 93.1 0.1 2.2 2 0 0 2 2 2 1 Histidine kinase HAMP PF00672.25 ACS99344.1 - 8.8e-13 48.4 0.0 2.8e-12 46.8 0.0 2.0 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACS99344.1 - 1.3e-08 35.3 0.0 3.5e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cache_3-Cache_2 PF17201.4 ACS99344.1 - 0.0014 17.9 0.2 0.0029 17.0 0.2 1.4 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain DUF1641 PF07849.11 ACS99344.1 - 0.0051 16.7 0.0 0.018 14.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1641) DUF3021 PF11457.8 ACS99344.1 - 0.0063 16.8 0.5 0.0063 16.8 0.5 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3021) FtsX PF02687.21 ACS99344.1 - 0.0092 16.4 0.5 0.91 10.0 0.2 2.5 2 0 0 2 2 2 1 FtsX-like permease family sCache_2 PF17200.4 ACS99344.1 - 0.014 15.3 0.0 0.062 13.2 0.0 2.1 1 1 0 1 1 1 0 Single Cache domain 2 dCache_2 PF08269.11 ACS99344.1 - 0.014 14.6 0.0 0.036 13.2 0.0 1.7 1 0 0 1 1 1 0 Cache domain HATPase_c_2 PF13581.6 ACS99344.1 - 0.017 15.0 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACS99344.1 - 0.018 14.8 0.0 0.053 13.4 0.0 1.7 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4329 PF14220.6 ACS99344.1 - 0.13 12.2 0.0 0.39 10.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4329) Response_reg PF00072.24 ACS99345.1 - 3.5e-27 94.8 0.7 7.1e-27 93.8 0.2 1.8 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99345.1 - 1.1e-23 83.3 0.1 1.9e-23 82.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99345.1 - 8.6e-16 57.6 0.0 8.8e-08 32.1 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACS99345.1 - 0.00019 21.7 0.0 0.00056 20.1 0.0 1.8 2 0 0 2 2 2 1 GGDEF-like domain Sigma70_r4 PF04545.16 ACS99345.1 - 0.0014 18.1 0.6 0.012 15.1 0.1 2.5 2 0 0 2 2 2 1 Sigma-70, region 4 FerI PF08151.12 ACS99345.1 - 0.016 15.3 0.0 0.29 11.3 0.0 2.4 2 0 0 2 2 2 0 FerI (NUC094) domain CAGE1 PF15066.6 ACS99345.1 - 0.02 13.6 0.2 0.039 12.6 0.1 1.5 2 0 0 2 2 2 0 Cancer-associated gene protein 1 family LysR_substrate PF03466.20 ACS99346.1 - 2.3e-55 187.2 0.0 2.9e-55 186.9 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACS99346.1 - 3.2e-19 68.6 0.4 6.7e-19 67.6 0.1 1.7 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family Rhodanese PF00581.20 ACS99347.1 - 2.4e-13 50.6 0.0 3e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain DUF975 PF06161.11 ACS99351.1 - 1.3e-53 182.3 4.2 4.5e-37 128.2 0.8 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF975) UPF0259 PF06790.11 ACS99351.1 - 0.001 18.9 2.6 0.001 18.9 2.6 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0259) GPDPase_memb PF10110.9 ACS99351.1 - 0.0042 15.9 0.1 0.0042 15.9 0.1 2.6 1 1 1 2 2 2 1 Membrane domain of glycerophosphoryl diester phosphodiesterase DUF2614 PF11023.8 ACS99351.1 - 0.025 14.7 4.0 0.2 11.7 0.7 2.5 2 1 0 2 2 2 0 Zinc-ribbon containing domain DUF2070 PF09843.9 ACS99351.1 - 1.4 7.1 10.1 1.7 6.8 10.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Phage_holin_4_2 PF04020.13 ACS99351.1 - 5.3 7.8 15.7 0.093 13.4 3.4 2.8 3 0 0 3 3 3 0 Mycobacterial 4 TMS phage holin, superfamily IV DUF2651 PF10852.8 ACS99352.1 - 1.4 9.6 11.8 4.9 7.8 0.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2651) CBM_11 PF03425.13 ACS99353.1 - 6.7e-24 84.7 8.4 6.1e-12 45.8 1.2 2.7 3 0 0 3 3 3 2 Carbohydrate binding domain (family 11) His_kinase PF06580.13 ACS99354.1 - 3.1e-25 88.3 1.9 3.1e-25 88.3 1.9 3.4 3 2 0 3 3 3 1 Histidine kinase dCache_1 PF02743.18 ACS99354.1 - 5.1e-16 59.2 7.8 8.3e-16 58.5 7.8 1.3 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 ACS99354.1 - 3e-11 43.5 0.3 7e-11 42.3 0.3 1.7 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACS99354.1 - 4.1e-10 40.1 0.1 1.3e-09 38.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACS99354.1 - 0.0013 18.6 0.0 0.0051 16.7 0.0 1.9 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 ACS99354.1 - 0.023 14.6 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain 4HB_MCP_1 PF12729.7 ACS99354.1 - 0.076 12.6 5.6 0.19 11.2 1.7 2.5 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction HATPase_c_3 PF13589.6 ACS99354.1 - 0.099 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3139 PF11337.8 ACS99354.1 - 0.13 12.9 2.6 0.39 11.4 2.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) IFP_35_N PF07334.13 ACS99354.1 - 0.14 12.2 0.0 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF4492 PF14899.6 ACS99354.1 - 0.31 11.0 4.8 0.095 12.6 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4492) Sigma_reg_N PF13800.6 ACS99354.1 - 2.6 8.4 9.2 3 8.2 1.3 2.6 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Response_reg PF00072.24 ACS99355.1 - 5.1e-28 97.5 0.0 1.2e-27 96.3 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99355.1 - 7.6e-20 71.0 0.0 2.5e-18 66.1 0.0 3.0 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99355.1 - 4.9e-18 64.8 0.0 3.5e-08 33.4 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACS99355.1 - 8.6e-06 26.0 0.1 3e-05 24.3 0.1 2.0 2 0 0 2 2 2 1 GGDEF-like domain SBP_bac_1 PF01547.25 ACS99356.1 - 2.2e-30 106.7 11.8 2.2e-30 106.7 11.8 1.8 3 0 0 3 3 3 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACS99357.1 - 4.5e-16 59.1 15.5 4.5e-16 59.1 15.5 2.1 2 0 0 2 2 2 2 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99358.1 - 1.1e-08 35.0 16.0 1.1e-08 35.0 16.0 1.8 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component CBM_11 PF03425.13 ACS99359.1 - 7.8e-41 139.9 12.1 5.5e-13 49.2 0.1 4.9 2 1 3 5 5 5 4 Carbohydrate binding domain (family 11) SLH PF00395.20 ACS99359.1 - 8.7e-38 128.1 6.5 5.6e-12 45.5 0.2 3.9 3 0 0 3 3 3 3 S-layer homology domain CIA30 PF08547.12 ACS99359.1 - 7.8e-17 61.8 0.0 6.1e-06 26.3 0.0 4.7 4 0 0 4 4 4 4 Complex I intermediate-associated protein 30 (CIA30) F5_F8_type_C PF00754.25 ACS99359.1 - 8.8e-05 22.6 10.4 0.0068 16.5 0.4 5.6 5 0 0 5 5 5 2 F5/8 type C domain Cellulase PF00150.18 ACS99359.1 - 0.00012 21.7 0.7 0.00021 20.8 0.7 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF5590 PF17881.1 ACS99359.1 - 0.2 11.8 1.8 11 6.2 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5590) AP_endonuc_2 PF01261.24 ACS99360.1 - 7.5e-24 84.3 0.0 1.2e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Glyco_hydro_67M PF07488.12 ACS99360.1 - 0.1 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 middle domain GntR PF00392.21 ACS99361.1 - 6.7e-20 70.5 0.0 1.3e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Peripla_BP_4 PF13407.6 ACS99361.1 - 3e-12 46.7 0.0 5.2e-09 36.0 0.0 2.1 1 1 1 2 2 2 2 Periplasmic binding protein domain Peripla_BP_3 PF13377.6 ACS99361.1 - 3.3e-11 43.8 0.0 5.1e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACS99361.1 - 3.4e-09 36.5 0.0 1.3e-08 34.7 0.0 1.7 1 1 0 2 2 2 1 Periplasmic binding proteins and sugar binding domain of LacI family HTH_DeoR PF08220.12 ACS99361.1 - 0.00035 20.2 0.1 0.0014 18.3 0.0 2.0 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_41 PF14502.6 ACS99361.1 - 0.011 15.4 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_11 PF08279.12 ACS99361.1 - 0.017 15.1 0.0 0.061 13.3 0.0 1.9 1 0 0 1 1 1 0 HTH domain TrmB PF01978.19 ACS99361.1 - 0.15 11.9 0.1 0.74 9.7 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB SBP_bac_8 PF13416.6 ACS99362.1 - 1.3e-32 113.8 9.9 2.3e-32 112.9 9.9 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACS99362.1 - 2.6e-31 109.7 9.5 4.1e-31 109.1 9.5 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACS99363.1 - 2.4e-16 60.0 7.1 2.4e-16 60.0 7.1 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99364.1 - 8.2e-16 58.3 14.6 8.2e-16 58.3 14.6 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Glyco_hydro_43 PF04616.14 ACS99365.1 - 7.9e-66 222.3 0.3 9.6e-66 222.0 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF3558 PF12079.8 ACS99366.1 - 0.015 15.3 2.4 0.024 14.6 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) Response_reg PF00072.24 ACS99367.1 - 2e-23 82.7 0.0 5.3e-23 81.3 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99367.1 - 4.2e-18 65.4 0.0 1.5e-17 63.7 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99367.1 - 1.1e-14 54.1 0.0 1.4e-08 34.6 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family V-SNARE PF05008.15 ACS99367.1 - 0.11 12.9 0.5 4.2 7.8 0.1 2.5 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus His_kinase PF06580.13 ACS99368.1 - 2.4e-21 75.8 0.6 7.3e-21 74.3 0.6 1.8 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACS99368.1 - 0.00082 19.7 0.0 0.0023 18.3 0.0 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACS99368.1 - 0.0012 19.4 0.0 0.003 18.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BPD_transp_1 PF00528.22 ACS99369.1 - 3e-11 43.4 16.8 3e-11 43.4 16.8 2.6 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99370.1 - 2.3e-08 34.0 26.4 1.7e-07 31.2 26.4 2.1 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Peripla_BP_2 PF01497.18 ACS99371.1 - 1.9e-26 93.1 0.6 2.5e-26 92.7 0.6 1.2 1 0 0 1 1 1 1 Periplasmic binding protein FecCD PF01032.18 ACS99372.1 - 4e-88 295.4 32.0 4.8e-88 295.1 32.0 1.1 1 0 0 1 1 1 1 FecCD transport family Adeno_E3 PF06040.11 ACS99372.1 - 0.53 10.5 3.0 1 9.5 0.0 2.6 2 1 1 3 3 3 0 Adenovirus E3 protein FecCD PF01032.18 ACS99373.1 - 4.9e-92 308.3 34.2 6.1e-92 308.0 34.2 1.1 1 0 0 1 1 1 1 FecCD transport family DUF840 PF05801.11 ACS99373.1 - 0.079 13.0 0.2 2 8.5 0.0 2.3 2 0 0 2 2 2 0 Lagovirus protein of unknown function (DUF840) Phage_holin_3_1 PF05106.12 ACS99373.1 - 2.4 8.6 5.7 2 8.9 2.9 2.4 2 1 0 2 2 2 0 Phage holin family (Lysis protein S) B12D PF06522.11 ACS99373.1 - 8.3 6.3 6.2 1.2 9.0 0.3 2.8 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit HTH_18 PF12833.7 ACS99374.1 - 1.8e-19 69.8 0.1 3.7e-19 68.8 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99374.1 - 7e-18 64.3 0.2 6.4e-08 32.5 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99374.1 - 0.012 15.5 0.1 0.027 14.4 0.1 1.5 1 1 0 1 1 1 0 AraC-like ligand binding domain Peripla_BP_2 PF01497.18 ACS99375.1 - 1.8e-30 106.3 3.0 2.4e-30 105.8 3.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein DUF975 PF06161.11 ACS99376.1 - 4.1e-49 167.6 7.7 1.7e-33 116.4 2.7 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF975) DUF2070 PF09843.9 ACS99376.1 - 2.9 6.1 11.5 3.6 5.8 11.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4199 PF13858.6 ACS99376.1 - 4.5 7.7 19.6 3.7 7.9 17.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4199) DHHC PF01529.20 ACS99376.1 - 6.9 6.8 12.0 5.6 7.1 6.4 2.1 1 1 1 2 2 2 0 DHHC palmitoyltransferase Big_9 PF17963.1 ACS99377.1 - 6.7e-236 763.9 282.4 4.5e-25 88.2 16.2 17.1 14 2 3 17 17 14 11 Bacterial Ig domain Cadherin_4 PF17803.1 ACS99377.1 - 5.4e-150 488.3 265.4 7.7e-17 61.7 8.0 18.1 17 2 1 18 18 17 11 Bacterial cadherin-like domain Cadherin_5 PF17892.1 ACS99377.1 - 1.4e-140 457.9 165.3 1.5e-16 60.2 7.8 14.1 14 0 0 14 14 14 11 Cadherin-like domain Cadherin_3 PF16184.5 ACS99377.1 - 1e-38 131.8 45.3 4.6e-06 26.6 0.4 13.7 11 2 0 11 11 11 10 Cadherin-like SLH PF00395.20 ACS99377.1 - 1.5e-31 108.1 0.3 1.3e-14 53.9 0.1 5.3 4 0 0 4 4 4 3 S-layer homology domain CarboxypepD_reg PF13620.6 ACS99377.1 - 2.7e-15 56.4 11.3 8.9e-15 54.7 1.1 15.9 15 2 2 17 17 17 4 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 ACS99377.1 - 7.4e-12 45.1 0.4 7.4e-12 45.1 0.4 14.1 14 2 2 16 16 14 3 Bacterial Ig-like domain (group 1) CarbopepD_reg_2 PF13715.6 ACS99377.1 - 8.6e-09 35.3 0.5 8.6e-09 35.3 0.5 7.3 8 0 0 8 8 8 2 CarboxypepD_reg-like domain Invasin_D3 PF09134.10 ACS99377.1 - 1.4e-06 28.5 1.9 1.4e-06 28.5 1.9 17.7 8 6 8 18 18 18 3 Invasin, domain 3 dTDP_sugar_isom PF00908.17 ACS99377.1 - 0.024 14.3 0.3 48 3.6 0.0 5.0 5 0 0 5 5 5 0 dTDP-4-dehydrorhamnose 3,5-epimerase HU-CCDC81_bac_2 PF18175.1 ACS99377.1 - 9.3 6.2 14.9 84 3.2 0.0 7.2 9 0 0 9 9 9 0 CCDC81-like prokaryotic HU domain 2 TetR_N PF00440.23 ACS99378.1 - 4.1e-12 45.7 0.0 6.6e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_7 PF14246.6 ACS99378.1 - 1.3e-06 28.4 0.2 4.9e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 AefR-like transcriptional repressor, C-terminal domain TetR_C_24 PF17932.1 ACS99378.1 - 1.4e-06 28.5 0.0 2.3e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_29 PF17938.1 ACS99378.1 - 0.00018 21.5 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_6 PF13977.6 ACS99378.1 - 0.0073 16.5 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 BetI-type transcriptional repressor, C-terminal ABC_tran PF00005.27 ACS99379.1 - 2.1e-31 109.3 0.0 3.2e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS99379.1 - 1.6e-13 51.1 0.1 4.9e-08 33.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS99379.1 - 3.3e-06 26.7 0.0 5e-05 22.8 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACS99379.1 - 0.00012 21.7 0.1 0.00029 20.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACS99379.1 - 0.002 18.1 0.1 0.005 16.8 0.1 1.6 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 ACS99379.1 - 0.0028 17.4 0.1 0.0054 16.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ACS99379.1 - 0.0076 16.8 0.0 0.013 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ACS99379.1 - 0.0086 15.5 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 ACS99379.1 - 0.0091 15.7 0.2 0.84 9.3 0.0 2.6 3 0 0 3 3 3 1 IstB-like ATP binding protein NB-ARC PF00931.22 ACS99379.1 - 0.071 12.3 0.1 0.2 10.8 0.1 1.7 1 1 0 1 1 1 0 NB-ARC domain ATPase_2 PF01637.18 ACS99379.1 - 0.094 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 ACS99379.1 - 0.12 12.5 0.1 0.28 11.3 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.6 ACS99379.1 - 0.13 11.8 0.2 6.1 6.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 ACS99379.1 - 0.14 12.5 0.2 0.36 11.1 0.2 2.0 1 1 0 1 1 1 0 AAA domain ABC2_membrane PF01061.24 ACS99380.1 - 6.4e-13 48.6 31.1 6.4e-13 48.6 31.1 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ACS99380.1 - 3.9e-09 36.1 32.2 3.9e-09 36.1 32.2 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein DUF5325 PF17259.2 ACS99380.1 - 0.11 12.4 0.6 0.11 12.4 0.6 3.2 4 1 0 4 4 4 0 Family of unknown function (DUF5325) Acetyltransf_1 PF00583.25 ACS99381.1 - 2.2e-17 63.3 0.0 2.6e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACS99381.1 - 2.6e-12 47.0 0.1 4e-12 46.4 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACS99381.1 - 6.6e-12 45.5 0.0 8.7e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACS99381.1 - 2.6e-08 34.0 0.0 3.3e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACS99381.1 - 0.00014 22.1 0.0 0.00018 21.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACS99381.1 - 0.00061 19.9 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_6 PF13480.7 ACS99381.1 - 0.015 15.5 0.0 0.025 14.8 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ACS99381.1 - 0.019 14.4 0.1 0.088 12.3 0.1 2.1 1 1 1 2 2 2 0 Putative acetyl-transferase FR47 PF08445.10 ACS99381.1 - 0.041 13.8 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein LPG_synthase_TM PF03706.13 ACS99382.1 - 2.4e-11 43.7 35.4 2.9e-11 43.5 35.4 1.1 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region Glycos_transf_1 PF00534.20 ACS99383.1 - 9.1e-40 136.0 0.0 1.4e-39 135.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99383.1 - 1.8e-27 96.4 0.2 3.5e-27 95.4 0.2 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACS99383.1 - 1.9e-17 63.8 0.1 5e-17 62.4 0.1 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACS99383.1 - 7.9e-12 45.9 0.0 2.7e-11 44.2 0.0 1.9 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ACS99383.1 - 1.5e-05 25.3 0.0 3.1e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 ACS99383.1 - 8.7e-05 22.6 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like MFS_1 PF07690.16 ACS99384.1 - 3.3e-34 118.3 80.4 9.2e-25 87.3 46.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRIQK PF15168.6 ACS99385.1 - 4.3 7.3 6.9 4.8 7.2 1.7 2.2 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family GGDEF PF00990.21 ACS99386.1 - 5.3e-43 146.6 0.5 8.4e-43 145.9 0.0 1.6 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain PAS PF00989.25 ACS99386.1 - 4.7e-07 29.8 0.1 5.3e-06 26.4 0.0 2.5 1 1 1 2 2 2 1 PAS fold PAS_9 PF13426.7 ACS99386.1 - 1.2e-06 28.7 0.0 3.9e-06 27.1 0.0 1.9 1 1 0 1 1 1 1 PAS domain PAS_8 PF13188.7 ACS99386.1 - 0.0012 18.8 0.0 0.025 14.6 0.0 3.0 4 0 0 4 4 4 1 PAS domain GGDEF_2 PF17853.1 ACS99386.1 - 0.0017 18.6 0.2 0.0033 17.7 0.2 1.5 1 0 0 1 1 1 1 GGDEF-like domain WbqC PF08889.11 ACS99386.1 - 0.027 14.4 1.1 0.06 13.3 1.1 1.6 1 0 0 1 1 1 0 WbqC-like protein family GRDA PF04723.14 ACS99386.1 - 0.075 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A PAS_3 PF08447.12 ACS99386.1 - 0.15 12.4 0.1 0.52 10.6 0.0 2.1 1 1 0 1 1 1 0 PAS fold DHR10 PF18595.1 ACS99386.1 - 8.3 6.5 16.8 0.29 11.2 9.1 2.4 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain Abhydrolase_1 PF00561.20 ACS99387.1 - 2.5e-19 69.9 0.6 5.3e-17 62.3 0.6 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACS99387.1 - 2.3e-17 64.3 0.0 2.7e-17 64.1 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACS99387.1 - 6.4e-13 48.5 0.1 1.1e-12 47.7 0.1 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 ACS99387.1 - 0.003 17.6 0.0 0.005 16.9 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Ndr PF03096.14 ACS99387.1 - 0.039 12.7 0.0 0.057 12.1 0.0 1.6 1 1 0 1 1 1 0 Ndr family Abhydrolase_2 PF02230.16 ACS99387.1 - 0.7 9.7 2.7 22 4.8 0.1 2.9 2 1 0 3 3 3 0 Phospholipase/Carboxylesterase HTH_18 PF12833.7 ACS99388.1 - 2.3e-14 53.4 0.0 4.9e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99388.1 - 7.7e-14 51.4 0.2 3e-06 27.2 0.1 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_24 PF13412.6 ACS99388.1 - 0.061 12.9 0.0 0.63 9.7 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Cu_amine_oxid PF01179.20 ACS99389.1 - 3.5e-130 434.6 1.4 4.4e-130 434.3 1.4 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 ACS99389.1 - 1e-27 96.5 0.0 3.8e-27 94.6 0.0 1.9 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 ACS99389.1 - 1.7e-20 73.0 0.3 4.9e-20 71.6 0.0 1.9 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain Cu_amine_oxidN1 PF07833.11 ACS99389.1 - 1.2e-15 57.7 0.0 3.4e-15 56.3 0.0 1.8 1 0 0 1 1 1 1 Copper amine oxidase N-terminal domain Acetyltransf_1 PF00583.25 ACS99390.1 - 5.8e-14 52.3 0.0 7.3e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACS99390.1 - 3.3e-13 49.7 0.0 4e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACS99390.1 - 1.2e-11 44.9 0.0 1.8e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACS99390.1 - 0.0036 17.5 0.0 0.0047 17.1 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACS99390.1 - 0.0044 17.0 0.0 0.0087 16.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ACS99390.1 - 0.0061 16.7 0.0 0.0087 16.2 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 ACS99390.1 - 0.0062 16.6 0.2 0.064 13.3 0.2 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ACS99390.1 - 0.034 14.1 0.0 0.065 13.2 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_5 PF13444.6 ACS99390.1 - 0.043 14.5 0.0 0.29 11.8 0.0 2.1 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 ACS99390.1 - 0.063 13.0 0.0 0.08 12.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ SL4P PF17618.2 ACS99390.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized Strongylid L4 protein 7tm_6 PF02949.20 ACS99391.1 - 0.18 10.9 2.0 0.22 10.6 2.0 1.1 1 0 0 1 1 1 0 7tm Odorant receptor CDP-OH_P_transf PF01066.21 ACS99392.1 - 3.1e-17 63.1 0.1 3.1e-17 63.1 0.1 2.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Lipase_2 PF01674.18 ACS99392.1 - 0.041 13.4 0.0 0.058 12.9 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 2) HD PF01966.22 ACS99393.1 - 2.4e-09 37.4 0.8 7.7e-09 35.8 0.2 2.1 2 1 0 2 2 2 1 HD domain RsbU_N PF08673.10 ACS99393.1 - 0.07 13.2 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain HD_4 PF13328.6 ACS99393.1 - 0.12 12.1 0.0 0.88 9.3 0.0 2.1 2 0 0 2 2 2 0 HD domain DUF5490 PF17593.2 ACS99393.1 - 0.16 12.0 2.1 0.72 9.9 0.0 2.8 3 1 0 3 3 3 0 Family of unknown function (DUF5490) Glyoxalase PF00903.25 ACS99394.1 - 1.5e-10 41.4 0.0 2.5e-10 40.6 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily YaeQ PF07152.12 ACS99394.1 - 0.056 13.0 0.0 0.086 12.4 0.0 1.2 1 0 0 1 1 1 0 YaeQ protein ABC_tran PF00005.27 ACS99395.1 - 9.2e-28 97.5 0.1 1.9e-27 96.4 0.1 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS99395.1 - 5.5e-11 42.8 0.1 2.6e-05 24.2 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ACS99395.1 - 8.2e-06 25.8 0.0 0.058 13.1 0.0 2.1 1 1 1 2 2 2 2 AAA ATPase domain DUF4162 PF13732.6 ACS99395.1 - 0.00032 21.4 0.1 0.0012 19.5 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) SMC_N PF02463.19 ACS99395.1 - 0.00093 18.7 0.3 1.3 8.4 0.1 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ACS99395.1 - 0.0041 17.3 0.1 0.095 13.0 0.1 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 ACS99395.1 - 0.014 16.0 0.6 0.024 15.2 0.6 1.8 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACS99395.1 - 0.028 14.3 0.1 0.051 13.5 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase SRP54 PF00448.22 ACS99395.1 - 0.032 13.9 0.9 0.071 12.7 0.9 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_22 PF13401.6 ACS99395.1 - 0.034 14.4 0.2 0.08 13.2 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ACS99395.1 - 0.046 14.2 0.5 0.38 11.2 0.5 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ACS99395.1 - 0.05 13.4 0.2 0.11 12.3 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cytomega_US3 PF05963.11 ACS99395.1 - 0.051 13.2 0.0 0.083 12.5 0.0 1.3 1 0 0 1 1 1 0 Cytomegalovirus US3 protein AAA_24 PF13479.6 ACS99395.1 - 0.063 13.0 1.5 0.34 10.6 0.9 2.1 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ACS99395.1 - 0.076 12.9 0.7 15 5.4 0.0 2.4 2 0 0 2 2 2 0 NTPase Rad17 PF03215.15 ACS99395.1 - 0.096 12.6 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain TsaE PF02367.17 ACS99395.1 - 0.12 12.3 0.6 0.38 10.8 0.3 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 ACS99395.1 - 0.14 11.9 1.7 0.39 10.4 0.4 2.1 2 1 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 ACS99396.1 - 1.2e-18 67.4 19.5 1.2e-18 67.4 19.5 2.0 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 ACS99396.1 - 1.3e-15 57.4 17.8 1.3e-15 57.4 17.8 1.6 1 1 1 2 2 2 1 ABC-2 type transporter ABC2_membrane_2 PF12679.7 ACS99396.1 - 3.9e-11 42.8 17.4 2.8e-10 40.0 17.4 2.1 1 1 0 1 1 1 1 ABC-2 family transporter protein CcmB PF03379.13 ACS99396.1 - 0.0012 18.4 0.8 0.0012 18.4 0.8 1.7 1 1 1 2 2 2 1 CcmB protein IncD PF17628.2 ACS99396.1 - 0.0016 18.2 0.8 0.003 17.3 0.8 1.4 1 0 0 1 1 1 1 Inclusion membrane protein D ABC2_membrane_4 PF12730.7 ACS99396.1 - 0.018 15.0 16.5 0.013 15.5 11.3 2.6 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF997 PF06196.12 ACS99396.1 - 1.6 8.8 8.5 0.33 11.0 0.8 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF997) PDR_CDR PF06422.12 ACS99396.1 - 2 8.4 5.4 0.62 10.0 0.1 2.6 3 0 0 3 3 3 0 CDR ABC transporter HisKA_3 PF07730.13 ACS99397.1 - 5.4e-20 71.7 4.6 5.4e-20 71.7 4.6 1.8 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACS99397.1 - 0.00011 22.6 0.0 0.0012 19.3 0.0 2.4 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACS99397.1 - 0.00037 20.5 0.1 0.00072 19.5 0.0 1.5 1 1 0 1 1 1 1 Histidine kinase-like ATPase domain DUF2069 PF09842.9 ACS99397.1 - 0.0048 17.1 2.3 0.0048 17.1 2.3 2.2 2 0 0 2 2 2 1 Predicted membrane protein (DUF2069) DUF2198 PF09964.9 ACS99397.1 - 6.9 6.8 7.0 0.23 11.6 0.5 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) Response_reg PF00072.24 ACS99398.1 - 1.1e-27 96.4 0.1 1.7e-27 95.8 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 ACS99398.1 - 1.2e-16 59.9 0.0 2e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACS99398.1 - 2.8e-08 33.3 0.4 7.5e-08 31.9 0.0 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACS99398.1 - 2.5e-07 30.1 0.1 5e-07 29.1 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_40 PF14493.6 ACS99398.1 - 0.00057 20.3 0.0 0.0016 18.8 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_10 PF04967.12 ACS99398.1 - 0.00084 19.1 0.2 2.6 7.9 0.0 3.2 3 0 0 3 3 3 2 HTH DNA binding domain HTH_23 PF13384.6 ACS99398.1 - 0.0025 17.5 0.0 0.0059 16.4 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.6 ACS99398.1 - 0.0051 16.3 0.1 0.013 15.0 0.1 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 ACS99398.1 - 0.018 14.9 0.0 0.05 13.6 0.0 1.7 1 0 0 1 1 1 0 HTH domain MarR_2 PF12802.7 ACS99398.1 - 0.045 13.6 0.1 0.44 10.5 0.1 2.2 2 0 0 2 2 2 0 MarR family RepB PF07506.11 ACS99398.1 - 0.076 13.1 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 RepB plasmid partitioning protein DUF742 PF05331.11 ACS99398.1 - 0.089 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF742) HTH_38 PF13936.6 ACS99398.1 - 0.16 11.8 0.1 0.33 10.7 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Acetyltransf_10 PF13673.7 ACS99399.1 - 9.5e-13 48.2 0.0 1.1e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACS99399.1 - 2.3e-09 37.5 0.0 2.8e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACS99399.1 - 5.6e-08 33.1 0.0 8.1e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACS99399.1 - 1.2e-05 25.4 0.0 0.00018 21.6 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACS99399.1 - 3.8e-05 23.6 0.0 0.00013 21.9 0.0 1.8 2 0 0 2 2 2 1 FR47-like protein PanZ PF12568.8 ACS99399.1 - 0.064 13.0 0.0 0.074 12.8 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_13 PF13880.6 ACS99399.1 - 0.13 12.3 0.0 0.33 10.9 0.0 1.7 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase LysR_substrate PF03466.20 ACS99400.1 - 4.2e-29 101.4 0.9 5.7e-29 101.0 0.9 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACS99400.1 - 1.1e-18 66.9 0.3 2.6e-18 65.7 0.3 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 ACS99400.1 - 0.013 15.3 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain PLU-1 PF08429.11 ACS99400.1 - 0.17 11.1 0.1 0.19 10.9 0.1 1.1 1 0 0 1 1 1 0 PLU-1-like protein Tautomerase_2 PF14552.6 ACS99401.1 - 1.1e-29 102.4 0.0 2e-29 101.5 0.0 1.4 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase PF01361.21 ACS99401.1 - 2e-10 40.4 0.0 1.4e-05 24.9 0.0 2.2 2 0 0 2 2 2 2 Tautomerase enzyme CMD PF02627.20 ACS99402.1 - 2.7e-21 75.4 0.4 3.3e-21 75.1 0.4 1.0 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Acetyltransf_3 PF13302.7 ACS99403.1 - 1.4e-11 45.2 0.0 1.7e-11 44.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACS99403.1 - 0.0036 17.5 0.0 0.005 17.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family bPH_4 PF06713.11 ACS99404.1 - 9.7e-21 73.6 0.0 1.2e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 Bacterial PH domain bPH_5 PF10882.8 ACS99404.1 - 0.0038 17.3 0.0 0.99 9.5 0.0 2.1 1 1 1 2 2 2 2 Bacterial PH domain His_kinase PF06580.13 ACS99405.1 - 6.3e-25 87.3 0.5 2.2e-24 85.6 0.1 2.3 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACS99405.1 - 5.1e-12 46.3 0.2 1.3e-11 45.0 0.2 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACS99405.1 - 2.6e-11 43.8 1.2 4e-11 43.2 1.2 1.3 1 0 0 1 1 1 1 Cache domain HATPase_c_2 PF13581.6 ACS99405.1 - 0.07 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACS99405.1 - 0.078 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Tetraspanin PF00335.20 ACS99405.1 - 0.96 9.1 2.6 1.4 8.5 0.5 1.9 2 0 0 2 2 2 0 Tetraspanin family Response_reg PF00072.24 ACS99406.1 - 5.2e-29 100.7 0.0 1.4e-28 99.3 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain HTH_AraC PF00165.23 ACS99406.1 - 1.7e-24 85.3 0.1 1.1e-12 47.7 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACS99406.1 - 1.1e-23 83.2 0.4 2e-23 82.5 0.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain FleQ PF06490.11 ACS99406.1 - 0.006 17.0 0.1 0.015 15.6 0.0 1.6 2 0 0 2 2 2 1 Flagellar regulatory protein FleQ TetR_N PF00440.23 ACS99406.1 - 0.0066 16.2 0.0 2.5 7.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory proteins, tetR family TFIIE_beta PF02186.15 ACS99406.1 - 0.016 15.5 0.1 0.24 11.7 0.0 2.7 3 0 0 3 3 3 0 TFIIE beta subunit core domain HTH_24 PF13412.6 ACS99406.1 - 0.027 14.0 0.0 7.5 6.2 0.1 2.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ACS99406.1 - 0.068 13.1 0.1 1.1 9.2 0.0 2.9 4 0 0 4 4 4 0 MarR family Peroxidase_2 PF01328.17 ACS99406.1 - 0.12 12.9 0.3 0.23 12.0 0.1 1.4 1 1 0 1 1 1 0 Peroxidase, family 2 SBP_bac_1 PF01547.25 ACS99407.1 - 1e-30 107.8 15.4 1.4e-30 107.3 15.4 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACS99407.1 - 5.2e-30 105.2 9.5 7.1e-30 104.8 9.5 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACS99407.1 - 7.8e-05 22.2 0.0 0.0026 17.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein DUF1344 PF07076.11 ACS99407.1 - 0.033 14.1 0.0 0.093 12.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) BPD_transp_1 PF00528.22 ACS99408.1 - 4.5e-19 68.9 16.3 3.3e-18 66.1 10.9 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component DUF4731 PF15875.5 ACS99408.1 - 1.2 9.3 6.4 0.75 10.0 1.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4731) BPD_transp_1 PF00528.22 ACS99409.1 - 5.8e-18 65.3 20.2 5.8e-18 65.3 20.2 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component ThiC_Rad_SAM PF01964.18 ACS99410.1 - 1.1e-203 676.7 0.0 1.3e-203 676.5 0.0 1.0 1 0 0 1 1 1 1 Radical SAM ThiC family ThiC-associated PF13667.6 ACS99410.1 - 2.2e-30 104.3 0.2 4.6e-30 103.3 0.2 1.6 1 0 0 1 1 1 1 ThiC-associated domain DUF5472 PF17566.2 ACS99411.1 - 0.12 12.3 0.5 0.27 11.2 0.2 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5472) DUF3950 PF13132.6 ACS99412.1 - 0.25 11.1 0.6 0.47 10.2 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3950) LPAM_1 PF08139.12 ACS99412.1 - 0.31 11.6 2.4 0.68 10.5 2.4 1.6 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site ADH_zinc_N_2 PF13602.6 ACS99413.1 - 9.5e-27 94.7 0.1 1.6e-26 93.9 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ACS99413.1 - 3.6e-17 62.6 0.0 7.5e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ACS99413.1 - 2.8e-07 30.4 0.0 7.6e-06 25.8 0.0 2.5 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ACP_syn_III_C PF08541.10 ACS99413.1 - 0.0064 16.6 0.2 0.019 15.1 0.2 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal AlaDh_PNT_C PF01262.21 ACS99413.1 - 0.019 14.2 0.2 0.037 13.3 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ChitinaseA_N PF08329.10 ACS99414.1 - 5.2e-11 42.3 1.4 0.00022 20.9 0.2 2.9 1 1 1 2 2 2 2 Chitinase A, N-terminal domain ABC_transp_aux PF09822.9 ACS99414.1 - 1e-06 28.4 0.0 2.8e-06 27.0 0.0 1.6 2 0 0 2 2 2 1 ABC-type uncharacterized transport system HYR PF02494.16 ACS99414.1 - 2.8e-06 27.5 4.5 0.00043 20.6 0.1 3.6 3 0 0 3 3 2 2 HYR domain ThuA PF06283.11 ACS99414.1 - 4.2e-05 23.8 0.1 9e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Trehalose utilisation CHB_HEX_C_1 PF13290.6 ACS99414.1 - 0.00087 19.3 5.1 0.0091 16.0 0.2 3.4 3 0 0 3 3 3 1 Chitobiase/beta-hexosaminidase C-terminal domain Big_3_2 PF12245.8 ACS99414.1 - 0.0045 17.3 9.9 0.16 12.2 0.8 4.3 4 0 0 4 4 4 2 Bacterial Ig-like domain Big_3_3 PF13750.6 ACS99414.1 - 0.0073 16.0 3.5 0.053 13.2 0.2 3.0 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 3) Ig_2 PF13895.6 ACS99414.1 - 0.01 16.1 6.9 1.8 9.0 0.2 4.3 4 0 0 4 4 4 0 Immunoglobulin domain DUF5011 PF16403.5 ACS99414.1 - 0.021 15.0 0.5 0.021 15.0 0.5 5.2 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) DUF4350 PF14258.6 ACS99414.1 - 0.036 14.5 0.0 0.2 12.1 0.0 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) GH115_C PF17829.1 ACS99414.1 - 0.067 13.0 5.8 11 5.8 0.0 4.0 3 1 1 4 4 4 0 Gylcosyl hydrolase family 115 C-terminal domain UPF0180 PF03698.13 ACS99414.1 - 0.12 12.6 0.1 1.7 8.9 0.0 2.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) CopC PF04234.12 ACS99414.1 - 0.16 13.1 9.1 3.5 8.7 0.1 4.6 3 1 0 3 3 3 0 CopC domain Big_6 PF17936.1 ACS99414.1 - 3.7 7.9 18.4 2.1 8.7 2.5 4.8 5 0 0 5 5 4 0 Bacterial Ig domain Acetyltransf_3 PF13302.7 ACS99415.1 - 7.2e-19 68.8 0.1 8.5e-19 68.6 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACS99415.1 - 5.2e-07 29.9 0.0 6.8e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 ACS99415.1 - 0.0057 16.8 0.0 0.008 16.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ACS99415.1 - 0.014 15.1 0.0 0.067 12.9 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF4878 PF12870.7 ACS99416.1 - 0.13 12.6 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4878) RDD PF06271.12 ACS99417.1 - 5.2e-12 46.2 1.1 2e-11 44.3 0.7 1.9 1 1 1 2 2 2 2 RDD family HTH_18 PF12833.7 ACS99418.1 - 1.3e-18 67.0 0.1 2.9e-18 65.9 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99418.1 - 4.2e-13 49.0 0.1 3.4e-05 23.8 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99418.1 - 3.6e-06 26.9 0.4 4.6e-05 23.3 0.7 2.3 2 1 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99418.1 - 4.5e-06 26.3 0.1 8.7e-06 25.4 0.1 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 ACS99418.1 - 0.0031 17.3 0.2 0.08 12.7 0.2 2.2 1 1 0 1 1 1 1 Cupin GFO_IDH_MocA PF01408.22 ACS99419.1 - 1.5e-28 100.0 0.1 2.4e-28 99.4 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACS99419.1 - 4.9e-11 42.7 0.1 9.4e-11 41.8 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain CoA_binding PF02629.19 ACS99419.1 - 4.2e-06 27.3 0.0 7.2e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 CoA binding domain NAD_binding_3 PF03447.16 ACS99419.1 - 3.7e-05 24.4 0.1 5.8e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.20 ACS99419.1 - 0.0041 17.2 0.2 0.0081 16.3 0.2 1.6 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Oxidoreduct_C PF16490.5 ACS99419.1 - 0.0083 15.9 0.1 0.012 15.4 0.1 1.2 1 0 0 1 1 1 1 Putative oxidoreductase C terminal domain IlvN PF07991.12 ACS99419.1 - 0.038 13.5 0.0 0.065 12.8 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 ACS99419.1 - 0.051 13.8 0.0 0.52 10.5 0.1 2.1 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACS99419.1 - 0.12 12.9 0.1 0.38 11.4 0.1 1.9 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ThiF PF00899.21 ACS99419.1 - 0.19 11.1 0.5 0.3 10.4 0.5 1.3 1 0 0 1 1 1 0 ThiF family GFO_IDH_MocA PF01408.22 ACS99420.1 - 2e-22 80.3 0.3 3e-22 79.7 0.3 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACS99420.1 - 3.1e-10 40.1 0.0 5.4e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain RACo_C_ter PF14574.6 ACS99420.1 - 0.017 14.2 0.1 0.024 13.7 0.1 1.2 1 0 0 1 1 1 0 C-terminal domain of RACo the ASKHA domain His_kinase PF06580.13 ACS99421.1 - 6.3e-26 90.5 0.2 2.1e-25 88.8 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACS99421.1 - 1.2e-07 32.2 0.0 2.8e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACS99421.1 - 4e-07 30.1 2.6 4e-07 30.1 2.6 1.7 2 0 0 2 2 2 1 Cache domain NleF_casp_inhib PF16809.5 ACS99421.1 - 0.061 13.2 6.2 0.13 12.2 0.6 2.7 2 1 0 2 2 2 0 NleF caspase inhibitor WSS_VP PF12175.8 ACS99421.1 - 0.082 12.4 1.0 0.15 11.5 1.0 1.4 1 0 0 1 1 1 0 White spot syndrome virus structural envelope protein VP Csm1_N PF18504.1 ACS99421.1 - 0.088 13.2 0.7 8.4 6.8 0.2 2.7 2 0 0 2 2 2 0 Csm1 N-terminal domain Response_reg PF00072.24 ACS99422.1 - 8.2e-23 80.7 0.0 1.5e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99422.1 - 2.6e-21 75.7 0.0 6.4e-21 74.4 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99422.1 - 2.8e-15 55.9 0.2 3.3e-09 36.6 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF1400 PF07176.11 ACS99422.1 - 0.099 12.9 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1400) UPF0122 PF04297.14 ACS99422.1 - 0.14 12.4 1.0 23 5.3 0.0 2.7 2 1 1 3 3 3 0 Putative helix-turn-helix protein, YlxM / p13 like BPD_transp_1 PF00528.22 ACS99423.1 - 5.5e-15 55.6 10.7 9.3e-15 54.8 10.7 1.4 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99424.1 - 1.2e-12 48.0 15.3 1.2e-12 48.0 15.3 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3270 PF11674.8 ACS99424.1 - 0.023 14.9 2.7 0.082 13.1 2.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) DUF4519 PF15012.6 ACS99424.1 - 9.9 6.4 7.5 1.5 9.0 1.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) SBP_bac_8 PF13416.6 ACS99425.1 - 1.7e-15 57.6 14.1 1.7e-15 57.6 14.1 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACS99425.1 - 8e-13 49.0 15.7 1.6e-12 48.1 15.7 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACS99425.1 - 3.5e-07 30.9 0.2 1.1e-06 29.3 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) Beta_helix PF13229.6 ACS99426.1 - 3.8e-06 26.9 0.0 2.2e-05 24.3 0.0 2.3 3 1 0 3 3 3 1 Right handed beta helix region Pectate_lyase_3 PF12708.7 ACS99426.1 - 0.00023 21.1 0.1 0.00075 19.4 0.1 2.0 2 1 0 2 2 2 1 Pectate lyase superfamily protein TPP_enzyme_N PF02776.18 ACS99426.1 - 0.0056 16.3 0.0 0.0097 15.5 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain NosD PF05048.13 ACS99426.1 - 0.13 11.5 0.0 0.83 8.9 0.0 2.2 2 1 0 2 2 2 0 Periplasmic copper-binding protein (NosD) TPR_5 PF12688.7 ACS99427.1 - 5.4e-13 49.2 0.0 7.9e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Tetratrico peptide repeat TPR_1 PF00515.28 ACS99427.1 - 1.1e-09 37.6 2.6 0.00089 19.0 0.1 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ACS99427.1 - 1.3e-09 37.4 3.1 0.016 15.3 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ACS99427.1 - 1e-08 35.5 0.2 0.00026 21.4 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ACS99427.1 - 1.6e-08 34.7 0.7 4.1e-07 30.2 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ACS99427.1 - 4.5e-08 33.3 0.4 0.031 15.1 0.0 3.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ACS99427.1 - 1.3e-07 31.2 3.4 0.0088 16.2 0.0 3.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ACS99427.1 - 8.1e-06 26.4 0.1 0.015 15.9 0.0 2.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ACS99427.1 - 8.5e-06 25.4 2.8 0.17 11.9 0.0 3.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ACS99427.1 - 0.00011 21.9 5.3 0.035 13.8 0.0 3.7 4 0 0 4 4 4 2 TPR repeat TPR_6 PF13174.6 ACS99427.1 - 0.00012 22.4 1.1 0.25 12.0 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 ACS99427.1 - 0.00051 19.8 0.9 7.4 6.6 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 ACS99427.1 - 0.0012 19.1 0.1 0.087 13.2 0.0 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 ACS99427.1 - 0.0015 18.6 0.8 3.8 7.7 0.0 3.5 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ACS99427.1 - 0.011 16.1 2.1 0.4 11.2 0.1 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ACS99427.1 - 0.071 13.4 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Nterm_IS4 PF13006.7 ACS99427.1 - 0.088 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Insertion element 4 transposase N-terminal DUF1963 PF09234.10 ACS99428.1 - 4.1e-54 184.3 0.2 5e-54 184.0 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1963) RA PF00788.23 ACS99428.1 - 0.13 12.9 0.0 0.3 11.7 0.0 1.6 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain Glyco_hydro_43 PF04616.14 ACS99429.1 - 5.8e-107 357.3 0.3 7.9e-107 356.8 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 ACS99429.1 - 1.4e-66 224.1 0.5 1.9e-66 223.7 0.5 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF1349 PF07081.11 ACS99429.1 - 7.9e-08 32.2 0.4 1.3e-07 31.5 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) Glyco_hydro_32N PF00251.20 ACS99429.1 - 0.015 14.9 0.1 0.38 10.3 0.0 2.4 1 1 1 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain HTH_18 PF12833.7 ACS99430.1 - 1.2e-23 83.2 0.0 2.3e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99430.1 - 9.4e-21 73.4 0.2 2.5e-09 37.0 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99430.1 - 1.1e-15 57.7 0.5 3.8e-15 56.0 0.5 1.8 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99430.1 - 7.1e-09 35.3 0.0 4.3e-08 32.7 0.0 1.9 2 0 0 2 2 2 1 Cupin domain Cupin_7 PF12973.7 ACS99430.1 - 0.00082 19.3 0.0 0.0026 17.7 0.0 1.7 2 0 0 2 2 2 1 ChrR Cupin-like domain DUF4863 PF16155.5 ACS99430.1 - 0.0031 17.4 0.0 0.0048 16.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4863) DMSP_lyase PF16867.5 ACS99430.1 - 0.0037 16.9 0.0 0.01 15.5 0.0 1.7 2 0 0 2 2 2 1 Dimethlysulfonioproprionate lyase AraC_N PF06719.13 ACS99430.1 - 0.0065 16.1 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 AraC-type transcriptional regulator N-terminus HTH_Crp_2 PF13545.6 ACS99430.1 - 0.018 15.0 0.3 5.6 7.0 0.0 2.7 2 1 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_23 PF13384.6 ACS99430.1 - 0.022 14.6 0.0 1.3 9.0 0.0 3.1 2 1 0 2 2 2 0 Homeodomain-like domain AraC_binding_2 PF14525.6 ACS99430.1 - 0.048 13.4 0.1 0.069 12.8 0.1 1.3 1 0 0 1 1 1 0 AraC-binding-like domain HTH_38 PF13936.6 ACS99430.1 - 0.11 12.3 0.0 0.81 9.5 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 ACS99430.1 - 0.15 11.5 0.5 0.32 10.4 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 SBP_bac_5 PF00496.22 ACS99431.1 - 2.1e-68 231.0 0.2 2.5e-68 230.8 0.2 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle Exo_endo_phos PF03372.23 ACS99432.1 - 2.2e-26 92.8 0.1 2.5e-26 92.6 0.1 1.0 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ACS99432.1 - 0.0014 18.4 0.0 0.0084 15.9 0.0 2.1 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase His_biosynth PF00977.21 ACS99433.1 - 4.5e-34 117.9 0.1 6.3e-34 117.4 0.1 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein BtpA PF03437.15 ACS99433.1 - 0.016 14.6 0.0 0.6 9.5 0.0 2.3 2 0 0 2 2 2 0 BtpA family Ribul_P_3_epim PF00834.19 ACS99433.1 - 0.049 13.0 0.0 0.093 12.1 0.0 1.4 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family ComA PF02679.15 ACS99433.1 - 0.075 12.5 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 (2R)-phospho-3-sulfolactate synthase (ComA) Aldolase PF01081.19 ACS99433.1 - 0.18 11.2 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 KDPG and KHG aldolase EamA PF00892.20 ACS99434.1 - 4.2e-34 117.6 42.3 1e-19 71.0 16.9 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 ACS99434.1 - 0.19 11.1 16.1 0.036 13.4 10.9 1.9 1 1 1 2 2 2 0 Triose-phosphate Transporter family DUF5493 PF17597.2 ACS99434.1 - 4.9 7.5 23.0 0.51 10.6 7.3 3.8 2 1 2 4 4 4 0 Family of unknown function (DUF5493) TssN PF17555.2 ACS99434.1 - 6.7 6.0 23.4 0.91 8.8 8.6 2.4 1 1 1 2 2 2 0 Type VI secretion system, TssN ABC_tran PF00005.27 ACS99435.1 - 5.7e-36 124.1 0.0 1.5e-35 122.7 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ACS99435.1 - 2.5e-08 34.1 0.2 0.00034 20.5 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 ACS99435.1 - 3e-05 23.0 0.1 0.028 13.2 0.0 2.1 2 0 0 2 2 2 2 Predicted ATPase of the ABC class Rad17 PF03215.15 ACS99435.1 - 0.00036 20.5 0.0 0.00072 19.5 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 ACS99435.1 - 0.00051 20.0 0.0 0.00087 19.2 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ACS99435.1 - 0.00089 19.5 0.7 0.0041 17.4 0.4 2.2 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 ACS99435.1 - 0.00089 19.7 0.2 0.0014 19.1 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 ACS99435.1 - 0.001 19.4 0.3 0.028 14.7 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACS99435.1 - 0.0014 18.4 0.1 0.0028 17.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 ACS99435.1 - 0.0016 18.6 0.0 0.016 15.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ACS99435.1 - 0.0017 18.8 0.2 0.013 15.9 0.2 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 ACS99435.1 - 0.016 14.4 0.1 0.051 12.8 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 ACS99435.1 - 0.016 15.1 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 ACS99435.1 - 0.036 14.6 0.3 0.071 13.6 0.3 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ACS99435.1 - 0.043 13.7 0.3 0.19 11.7 0.1 2.0 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.6 ACS99435.1 - 0.055 13.5 0.0 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 ACS99435.1 - 0.088 12.2 0.1 1.2 8.5 0.1 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ACS99435.1 - 0.1 12.3 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 ACS99435.1 - 0.11 12.1 0.1 0.26 10.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ACS99435.1 - 0.12 12.9 0.1 0.18 12.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ACS99435.1 - 0.12 12.0 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ACS99435.1 - 0.13 11.6 0.0 0.5 9.7 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.25 ACS99435.1 - 0.13 11.9 0.1 0.19 11.3 0.1 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain PhoH PF02562.16 ACS99435.1 - 0.13 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein MMR_HSR1 PF01926.23 ACS99435.1 - 0.16 12.0 0.0 0.5 10.5 0.0 1.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 ACS99435.1 - 0.19 12.1 0.0 0.35 11.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase BPD_transp_1 PF00528.22 ACS99436.1 - 2.3e-24 86.2 10.5 4e-24 85.4 10.5 1.4 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component RNase_T PF00929.24 ACS99437.1 - 6.4e-19 69.1 0.0 1e-18 68.4 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 ACS99437.1 - 0.00024 21.1 0.5 0.0023 18.0 0.5 2.3 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like FPN1 PF06963.12 ACS99437.1 - 0.092 11.3 0.0 0.18 10.4 0.0 1.4 1 0 0 1 1 1 0 Ferroportin1 (FPN1) TetR_N PF00440.23 ACS99438.1 - 5.8e-12 45.2 0.8 1.1e-11 44.4 0.8 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_24 PF17932.1 ACS99438.1 - 1.2e-09 38.4 0.0 2e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_4 PF08359.11 ACS99438.1 - 0.0087 16.2 0.1 0.014 15.6 0.1 1.3 1 0 0 1 1 1 1 YsiA-like protein, C-terminal region TetR_C_6 PF13977.6 ACS99438.1 - 0.017 15.3 0.4 0.032 14.5 0.4 1.4 1 0 0 1 1 1 0 BetI-type transcriptional repressor, C-terminal TetR_C_10 PF16295.5 ACS99438.1 - 0.083 13.2 0.1 0.96 9.7 0.0 2.1 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain NMT1 PF09084.11 ACS99439.1 - 4.6e-25 88.8 0.0 6e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 ACS99439.1 - 1.1e-17 64.6 0.0 1.5e-17 64.1 0.0 1.2 1 0 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.20 ACS99439.1 - 1.9e-09 37.3 0.0 4.7e-08 32.7 0.1 2.4 1 1 1 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 Phosphonate-bd PF12974.7 ACS99439.1 - 3.6e-08 33.3 0.2 5.2e-08 32.8 0.2 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1_3 PF16868.5 ACS99439.1 - 9e-06 25.3 0.0 1.9e-05 24.2 0.0 1.5 1 1 0 1 1 1 1 NMT1-like family Big_4 PF07532.11 ACS99439.1 - 0.068 12.9 0.3 4.7 7.0 0.0 2.7 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 4) TauD PF02668.16 ACS99440.1 - 9.6e-64 215.8 0.2 1.2e-63 215.5 0.2 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Glyoxalase_3 PF13468.6 ACS99440.1 - 0.11 12.7 0.2 1.2 9.3 0.0 2.4 1 1 2 3 3 3 0 Glyoxalase-like domain Dabb PF07876.12 ACS99441.1 - 1.3e-22 80.2 0.7 1.4e-22 80.1 0.7 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain DUF2642 PF10842.8 ACS99442.1 - 8.2e-06 25.6 0.0 1e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2642) DUF348 PF03990.14 ACS99442.1 - 0.078 12.7 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain Aldolase PF01081.19 ACS99443.1 - 2.6e-42 144.5 1.5 3.2e-42 144.2 1.5 1.1 1 0 0 1 1 1 1 KDPG and KHG aldolase FMN_dh PF01070.18 ACS99443.1 - 0.074 12.1 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Radical_SAM PF04055.21 ACS99443.1 - 0.16 12.3 0.0 0.63 10.4 0.0 1.8 1 1 1 2 2 2 0 Radical SAM superfamily Lyase_1 PF00206.20 ACS99444.1 - 1.5e-110 369.4 0.4 2e-110 369.1 0.4 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 ACS99444.1 - 3.6e-25 88.1 0.1 3.6e-25 88.1 0.1 2.3 2 0 0 2 2 2 1 Fumarase C C-terminus ABC_tran PF00005.27 ACS99445.1 - 2.6e-49 167.3 1.7 2.1e-25 89.8 0.0 3.2 3 1 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 ACS99445.1 - 8.1e-16 58.7 1.3 0.0033 17.3 0.0 4.5 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_CTD PF16326.5 ACS99445.1 - 1.4e-15 57.3 10.0 1.4e-15 57.3 10.0 2.9 3 0 0 3 3 2 1 ABC transporter C-terminal domain ABC_tran_Xtn PF12848.7 ACS99445.1 - 9e-13 48.1 2.6 9e-13 48.1 2.6 4.0 3 1 1 4 4 4 1 ABC transporter SMC_N PF02463.19 ACS99445.1 - 1.9e-08 34.1 5.2 0.00083 18.8 2.1 4.3 2 2 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACS99445.1 - 1.6e-05 24.5 0.2 0.23 11.2 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 ACS99445.1 - 0.00019 21.3 0.3 0.48 10.1 0.0 2.8 3 0 0 3 3 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 ACS99445.1 - 0.0002 21.4 1.8 0.27 11.3 0.0 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase MeaB PF03308.16 ACS99445.1 - 0.0006 18.9 0.7 1 8.3 0.0 2.7 2 1 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 ACS99445.1 - 0.0007 19.7 0.5 0.29 11.2 0.0 3.7 3 1 0 3 3 3 1 Dynamin family AAA_33 PF13671.6 ACS99445.1 - 0.0012 19.0 1.9 7 6.8 0.0 4.6 4 0 0 4 4 4 0 AAA domain NACHT PF05729.12 ACS99445.1 - 0.0012 18.7 4.6 0.063 13.2 0.0 3.1 4 0 0 4 4 4 1 NACHT domain AAA_30 PF13604.6 ACS99445.1 - 0.0017 18.1 1.2 2.9 7.6 0.9 3.7 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ACS99445.1 - 0.003 17.5 0.1 3.1 7.7 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 ACS99445.1 - 0.012 15.3 0.2 0.89 9.2 0.2 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ACS99445.1 - 0.014 15.8 0.3 0.81 10.1 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 ACS99445.1 - 0.014 15.8 0.4 9 6.7 0.0 3.5 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Spectrin PF00435.21 ACS99445.1 - 0.019 15.5 15.5 0.16 12.5 8.3 3.1 2 0 0 2 2 2 0 Spectrin repeat NB-ARC PF00931.22 ACS99445.1 - 0.023 13.9 1.2 0.39 9.9 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain ATP-synt_ab PF00006.25 ACS99445.1 - 0.03 14.0 0.0 0.43 10.2 0.0 2.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_22 PF13401.6 ACS99445.1 - 0.047 14.0 5.3 5.5 7.3 0.1 4.0 3 2 0 3 3 3 0 AAA domain AAA_28 PF13521.6 ACS99445.1 - 0.065 13.5 0.5 8.2 6.6 0.0 3.4 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 ACS99445.1 - 0.096 12.9 0.5 15 5.8 0.0 3.1 4 0 0 4 4 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 ACS99445.1 - 0.11 13.0 23.2 0.39 11.2 0.0 4.1 4 1 0 4 4 3 0 AAA domain DUF87 PF01935.17 ACS99445.1 - 0.12 12.5 9.7 2 8.5 0.0 3.8 4 1 0 4 4 4 0 Helicase HerA, central domain AAA_16 PF13191.6 ACS99445.1 - 0.12 12.8 5.4 2.4 8.5 0.0 3.3 3 1 0 3 3 3 0 AAA ATPase domain KAP_NTPase PF07693.14 ACS99445.1 - 0.46 9.7 0.0 0.46 9.7 0.0 2.9 4 0 0 4 4 3 0 KAP family P-loop domain AAA_13 PF13166.6 ACS99445.1 - 1.2 7.7 11.3 4.1 5.9 0.0 4.2 4 1 1 5 5 5 0 AAA domain NTPase_1 PF03266.15 ACS99445.1 - 1.8 8.4 9.4 0.61 10.0 0.1 3.7 5 0 0 5 5 5 0 NTPase AAA_18 PF13238.6 ACS99445.1 - 2.1 8.9 8.7 8.5 6.9 1.8 4.1 3 1 1 4 4 4 0 AAA domain FAA_hydrolase PF01557.18 ACS99446.1 - 1.4e-40 139.3 0.0 1.7e-40 139.0 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family MFS_1 PF07690.16 ACS99447.1 - 1.7e-53 181.8 52.9 8.9e-52 176.2 50.2 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACS99447.1 - 2e-17 63.2 45.4 1.6e-13 50.3 14.9 3.9 4 1 0 4 4 4 2 Sugar (and other) transporter MFS_2 PF13347.6 ACS99447.1 - 4.6e-15 55.1 33.1 1.7e-10 40.1 19.3 2.8 3 1 0 3 3 3 2 MFS/sugar transport protein TRI12 PF06609.13 ACS99447.1 - 5e-12 45.0 14.3 5e-12 45.0 14.3 2.1 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) ApoO PF09769.9 ACS99447.1 - 1.4 8.9 4.3 9.5 6.2 0.0 2.9 2 1 1 3 3 3 0 Apolipoprotein O Ferritin PF00210.24 ACS99448.1 - 2.1e-34 118.5 3.0 2.5e-34 118.2 3.0 1.0 1 0 0 1 1 1 1 Ferritin-like domain Peripla_BP_3 PF13377.6 ACS99449.1 - 1.4e-39 136.1 0.0 2.6e-39 135.2 0.0 1.5 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACS99449.1 - 3.6e-33 115.2 0.0 4.4e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACS99449.1 - 6.9e-22 77.0 0.3 2.3e-21 75.3 0.3 2.0 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACS99449.1 - 6.7e-10 39.0 0.0 9.4e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_3 PF01381.22 ACS99449.1 - 7.5e-05 22.7 0.0 0.00018 21.5 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix HTH_38 PF13936.6 ACS99449.1 - 0.00044 19.9 0.5 0.0019 17.9 0.0 2.4 3 0 0 3 3 2 1 Helix-turn-helix domain HTH_23 PF13384.6 ACS99449.1 - 0.0016 18.2 0.0 0.0054 16.5 0.0 1.8 2 0 0 2 2 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 ACS99449.1 - 0.0051 16.2 0.1 0.01 15.2 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 TetR_N PF00440.23 ACS99449.1 - 0.0088 15.8 0.1 0.034 13.9 0.1 2.0 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family SpoIIID PF12116.8 ACS99449.1 - 0.014 15.5 0.5 0.035 14.2 0.1 1.8 2 0 0 2 2 2 0 Stage III sporulation protein D HTH_AraC PF00165.23 ACS99449.1 - 0.015 15.4 0.0 0.048 13.8 0.0 1.9 2 0 0 2 2 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_24 PF13412.6 ACS99449.1 - 0.016 14.8 0.0 0.039 13.5 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ACS99449.1 - 0.016 15.1 0.0 0.039 13.8 0.0 1.7 1 0 0 1 1 1 0 MarR family HTH_7 PF02796.15 ACS99449.1 - 0.017 15.2 0.1 0.066 13.3 0.1 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Crp PF00325.20 ACS99449.1 - 0.022 14.4 0.1 0.3 10.8 0.0 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family MarR PF01047.22 ACS99449.1 - 0.03 14.3 1.1 0.068 13.1 0.1 2.1 2 1 0 2 2 2 0 MarR family HTH_10 PF04967.12 ACS99449.1 - 0.036 13.9 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 HTH DNA binding domain HTH_IclR PF09339.10 ACS99449.1 - 0.037 13.8 0.0 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain Sigma54_DBD PF04552.13 ACS99449.1 - 0.045 13.5 0.7 0.072 12.8 0.1 1.7 2 1 0 2 2 1 0 Sigma-54, DNA binding domain rRNA_methylase PF06962.12 ACS99449.1 - 0.061 13.3 0.1 0.37 10.8 0.0 2.1 2 0 0 2 2 2 0 Putative rRNA methylase MerR PF00376.23 ACS99449.1 - 0.064 13.0 0.7 0.15 11.8 0.2 1.9 2 0 0 2 2 1 0 MerR family regulatory protein HTH_Crp_2 PF13545.6 ACS99449.1 - 0.078 13.0 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_6 PF01418.17 ACS99449.1 - 0.095 12.7 0.2 0.27 11.3 0.2 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family HTH_5 PF01022.20 ACS99449.1 - 0.11 12.4 0.4 0.35 10.8 0.0 2.0 3 0 0 3 3 2 0 Bacterial regulatory protein, arsR family HTH_28 PF13518.6 ACS99449.1 - 0.11 12.6 0.0 0.5 10.5 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_29 PF13551.6 ACS99449.1 - 0.12 12.4 0.1 0.45 10.6 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn helix HTH_26 PF13443.6 ACS99449.1 - 0.12 12.8 0.0 0.37 11.3 0.0 1.8 1 1 1 2 2 1 0 Cro/C1-type HTH DNA-binding domain Fe_dep_repress PF01325.19 ACS99449.1 - 0.27 11.4 2.1 0.47 10.7 0.4 2.2 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain SBP_bac_8 PF13416.6 ACS99450.1 - 1.1e-47 163.2 10.2 1.8e-47 162.5 10.2 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACS99450.1 - 0.00037 20.3 0.0 0.0058 16.4 0.0 2.2 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACS99451.1 - 5.3e-17 62.1 14.9 5.3e-17 62.1 14.9 3.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Baculo_11_kDa PF06143.11 ACS99451.1 - 3.1 7.4 6.4 5.9 6.6 0.1 3.3 3 0 0 3 3 3 0 Baculovirus 11 kDa family BPD_transp_1 PF00528.22 ACS99452.1 - 4e-17 62.6 16.3 4e-17 62.6 16.3 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Cytomega_US3 PF05963.11 ACS99452.1 - 0.055 13.1 0.1 0.095 12.3 0.1 1.4 1 0 0 1 1 1 0 Cytomegalovirus US3 protein COX8 PF02285.15 ACS99452.1 - 0.15 12.0 1.4 0.63 10.0 1.4 2.1 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIII Alpha-amylase PF00128.24 ACS99453.1 - 5.3e-83 279.4 0.0 8.2e-83 278.7 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF3459 PF11941.8 ACS99453.1 - 3.8e-08 33.5 0.0 7.9e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) Malt_amylase_C PF16657.5 ACS99453.1 - 6.5e-07 29.4 0.0 2e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 Maltogenic Amylase, C-terminal domain Glyco_hydro_77 PF02446.17 ACS99453.1 - 0.0011 17.9 0.0 0.065 12.1 0.0 2.0 1 1 1 2 2 2 2 4-alpha-glucanotransferase hDGE_amylase PF14701.6 ACS99453.1 - 0.037 13.1 0.0 0.056 12.5 0.0 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Cyc-maltodext_C PF10438.9 ACS99453.1 - 0.1 12.7 0.0 2.7 8.1 0.0 2.4 2 0 0 2 2 2 0 Cyclo-malto-dextrinase C-terminal domain Orai-1 PF07856.12 ACS99454.1 - 2.3 7.9 7.1 3 7.5 1.6 2.3 1 1 1 2 2 2 0 Mediator of CRAC channel activity DUF3671 PF12420.8 ACS99454.1 - 3.5 7.7 6.5 15 5.7 6.5 2.1 1 1 0 1 1 1 0 Protein of unknown function DUF4131 PF13567.6 ACS99454.1 - 3.6 7.2 7.5 0.61 9.7 3.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Response_reg PF00072.24 ACS99455.1 - 6.4e-22 77.8 0.0 1.2e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACS99455.1 - 8.2e-21 73.6 0.7 4.7e-11 42.5 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACS99455.1 - 7.4e-19 67.8 0.0 1.4e-17 63.7 0.0 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain GGDEF_2 PF17853.1 ACS99455.1 - 1e-08 35.4 0.1 5.7e-08 33.0 0.0 2.2 2 0 0 2 2 2 1 GGDEF-like domain AdoHcyase PF05221.17 ACS99455.1 - 0.17 11.0 1.0 1.3 8.1 0.1 2.3 3 0 0 3 3 3 0 S-adenosyl-L-homocysteine hydrolase Hemerythrin PF01814.23 ACS99455.1 - 1.8 9.2 8.2 6 7.5 1.5 3.3 3 0 0 3 3 3 0 Hemerythrin HHE cation binding domain His_kinase PF06580.13 ACS99456.1 - 9.6e-23 80.3 0.1 3.2e-22 78.6 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACS99456.1 - 7.2e-20 71.8 5.0 7.2e-20 71.8 5.0 1.6 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACS99456.1 - 4.2e-11 43.3 0.0 9e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACS99456.1 - 1e-10 41.8 0.0 2e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 HAMP domain Cache_3-Cache_2 PF17201.4 ACS99456.1 - 0.00026 20.3 0.1 0.00092 18.6 0.0 1.9 2 0 0 2 2 2 1 Cache 3/Cache 2 fusion domain 4HB_MCP_1 PF12729.7 ACS99456.1 - 0.0031 17.1 4.6 0.12 11.9 0.5 2.5 2 0 0 2 2 2 2 Four helix bundle sensory module for signal transduction HATPase_c_3 PF13589.6 ACS99456.1 - 0.06 13.2 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SBP_bac_1 PF01547.25 ACS99457.1 - 2.3e-37 129.6 16.1 4e-37 128.8 16.1 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACS99457.1 - 5e-32 111.8 14.7 7.3e-32 111.3 14.3 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACS99458.1 - 6.2e-10 39.1 23.0 2.3e-09 37.3 22.9 1.9 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF2417 PF10329.9 ACS99458.1 - 0.015 14.7 0.0 0.015 14.7 0.0 2.3 3 0 0 3 3 3 0 Region of unknown function (DUF2417) BPD_transp_1 PF00528.22 ACS99459.1 - 1e-18 67.7 16.1 1e-18 67.7 16.1 2.5 2 1 1 3 3 3 1 Binding-protein-dependent transport system inner membrane component BBS1 PF14779.6 ACS99459.1 - 0.088 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 TPPK_C PF12555.8 ACS99459.1 - 4.6 7.4 8.3 0.19 11.8 0.3 2.7 3 0 0 3 3 3 0 Thiamine pyrophosphokinase C terminal adh_short_C2 PF13561.6 ACS99460.1 - 5.4e-65 219.2 0.5 7e-65 218.8 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACS99460.1 - 8e-54 182.1 0.2 1e-53 181.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACS99460.1 - 5.2e-12 46.0 0.2 1.7e-11 44.4 0.2 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ACS99460.1 - 2.1e-05 24.1 0.1 3.1e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 ACS99460.1 - 0.0055 16.6 0.2 0.011 15.6 0.2 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ACS99460.1 - 0.031 14.5 0.1 0.15 12.2 0.1 2.0 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase GDP_Man_Dehyd PF16363.5 ACS99460.1 - 0.12 11.8 0.0 0.63 9.4 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ACS99460.1 - 0.14 11.7 1.3 0.98 8.9 0.4 2.0 2 0 0 2 2 2 0 NmrA-like family DUF1776 PF08643.10 ACS99460.1 - 0.19 11.0 0.0 0.4 10.0 0.0 1.4 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) PALP PF00291.25 ACS99460.1 - 2.3 7.6 7.2 7 6.0 0.5 2.7 2 1 0 3 3 3 0 Pyridoxal-phosphate dependent enzyme MR_MLE_C PF13378.6 ACS99461.1 - 5e-66 222.4 0.4 1.9e-65 220.5 0.1 1.8 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ACS99461.1 - 2.6e-24 85.7 0.0 9.3e-24 83.9 0.0 1.8 2 0 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Alpha-amylase PF00128.24 ACS99462.1 - 3.1e-85 286.7 0.1 4.6e-85 286.1 0.1 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_N PF02903.14 ACS99462.1 - 5.2e-42 142.8 0.0 9.6e-42 141.9 0.0 1.5 1 0 0 1 1 1 1 Alpha amylase, N-terminal ig-like domain Malt_amylase_C PF16657.5 ACS99462.1 - 1.4e-09 37.9 0.0 6.8e-09 35.7 0.0 2.3 2 0 0 2 2 2 1 Maltogenic Amylase, C-terminal domain DUF3459 PF11941.8 ACS99462.1 - 2e-06 28.0 0.1 5e-06 26.7 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) hDGE_amylase PF14701.6 ACS99462.1 - 0.0015 17.7 0.0 0.0023 17.1 0.0 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GHL6 PF14871.6 ACS99462.1 - 0.0031 17.6 0.0 0.008 16.3 0.0 1.6 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase 6 Alpha-amylase_C PF02806.18 ACS99462.1 - 0.0034 17.8 0.0 0.013 15.9 0.0 2.0 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Pyr_redox_2 PF07992.14 ACS99463.1 - 2.4e-52 178.0 0.1 2.7e-52 177.8 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACS99463.1 - 9.3e-28 97.3 0.5 1.8e-21 76.7 0.0 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACS99463.1 - 2.2e-18 66.6 0.8 4.2e-15 56.1 0.2 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ACS99463.1 - 1.8e-08 34.5 0.0 1.3e-06 28.5 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ACS99463.1 - 6.1e-08 32.6 0.2 0.012 15.2 0.0 3.0 3 0 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ACS99463.1 - 5e-07 29.1 0.9 0.0013 18.0 0.0 3.2 2 1 0 3 3 3 2 FAD binding domain HI0933_like PF03486.14 ACS99463.1 - 1.7e-06 27.0 0.1 0.0023 16.7 0.0 3.3 4 0 0 4 4 4 1 HI0933-like protein FAD_binding_3 PF01494.19 ACS99463.1 - 4.6e-05 22.8 0.0 0.0055 16.0 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain NAD_binding_7 PF13241.6 ACS99463.1 - 9.4e-05 22.8 0.1 0.0023 18.3 0.0 2.4 3 0 0 3 3 2 1 Putative NAD(P)-binding K_oxygenase PF13434.6 ACS99463.1 - 0.00016 20.9 0.1 0.14 11.3 0.0 3.1 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 ACS99463.1 - 0.00018 20.9 0.0 0.0021 17.4 0.0 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 ACS99463.1 - 0.0018 18.3 0.5 2 8.4 0.1 3.5 3 1 1 4 4 4 1 FAD-NAD(P)-binding GIDA PF01134.22 ACS99463.1 - 0.0048 16.0 5.0 0.032 13.3 0.1 3.7 2 2 1 4 4 4 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 ACS99463.1 - 0.0072 15.7 0.1 0.036 13.4 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 ACS99463.1 - 0.0076 16.3 0.1 0.43 10.6 0.0 2.6 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase Trp_halogenase PF04820.14 ACS99463.1 - 0.011 14.7 0.8 0.34 9.7 0.2 2.5 3 0 0 3 3 3 0 Tryptophan halogenase Lycopene_cycl PF05834.12 ACS99463.1 - 0.019 14.0 0.1 2.2 7.2 0.1 2.4 2 0 0 2 2 2 0 Lycopene cyclase protein MCRA PF06100.11 ACS99463.1 - 0.036 12.9 0.0 1.1 8.0 0.0 2.2 2 0 0 2 2 2 0 MCRA family Staph_opine_DH PF10100.9 ACS99463.1 - 0.15 10.7 0.0 1.4 7.5 0.0 2.3 3 0 0 3 3 3 0 Staphylopine dehydrogenase Response_reg PF00072.24 ACS99464.1 - 4.8e-31 107.2 0.0 6.8e-31 106.7 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACS99464.1 - 6e-23 80.7 0.0 1.1e-22 79.9 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal TusA PF01206.17 ACS99464.1 - 0.084 12.7 0.1 0.25 11.2 0.0 1.8 2 0 0 2 2 2 0 Sulfurtransferase TusA SSXRD PF09514.10 ACS99464.1 - 0.13 11.9 0.1 0.3 10.7 0.1 1.7 1 0 0 1 1 1 0 SSXRD motif HATPase_c PF02518.26 ACS99465.1 - 1.2e-28 99.8 0.1 2.7e-28 98.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACS99465.1 - 5.6e-16 58.3 0.4 4.2e-15 55.5 0.2 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACS99465.1 - 5.1e-15 55.6 0.0 1.3e-14 54.2 0.0 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c_5 PF14501.6 ACS99465.1 - 0.0004 20.3 0.0 0.00072 19.4 0.0 1.5 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 ACS99465.1 - 0.0069 16.3 0.0 0.019 14.9 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACS99465.1 - 0.015 15.1 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cortexin PF11057.8 ACS99465.1 - 0.12 12.3 0.1 0.12 12.3 0.1 1.9 2 0 0 2 2 2 0 Cortexin of kidney T_cell_tran_alt PF15128.6 ACS99465.1 - 0.18 11.6 0.4 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 T-cell leukemia translocation-altered Sigma_reg_N PF13800.6 ACS99465.1 - 1.1 9.6 4.0 28 5.1 0.5 2.8 3 0 0 3 3 3 0 Sigma factor regulator N-terminal NTP_transferase PF00483.23 ACS99466.1 - 2.7e-33 115.6 0.0 3.4e-33 115.3 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACS99466.1 - 4.7e-11 43.3 0.0 6.8e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.19 ACS99466.1 - 0.012 15.5 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase ABC_tran PF00005.27 ACS99467.1 - 5.4e-34 117.6 0.0 1.2e-33 116.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABM PF03992.16 ACS99467.1 - 2.3e-16 59.7 0.2 4.3e-16 58.8 0.2 1.5 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase AAA_21 PF13304.6 ACS99467.1 - 1.5e-10 41.4 1.4 3.7e-06 27.0 0.4 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS99467.1 - 2.3e-07 30.5 6.2 2.2e-06 27.2 3.1 2.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 ACS99467.1 - 1.6e-06 27.2 0.7 0.015 14.2 0.1 2.2 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 ACS99467.1 - 8.1e-06 26.3 0.1 2.2e-05 24.9 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 ACS99467.1 - 3.6e-05 23.7 0.3 0.00069 19.4 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ACS99467.1 - 4e-05 23.3 0.2 8.2e-05 22.3 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACS99467.1 - 6.6e-05 23.5 0.4 6.6e-05 23.5 0.4 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ACS99467.1 - 0.00039 20.7 1.0 0.0096 16.2 1.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ACS99467.1 - 0.015 14.9 0.1 0.043 13.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACS99467.1 - 0.015 15.2 0.2 0.037 13.9 0.1 1.7 2 0 0 2 2 1 0 RsgA GTPase AAA_30 PF13604.6 ACS99467.1 - 0.021 14.6 1.0 0.084 12.6 1.0 2.1 1 1 0 1 1 1 0 AAA domain DUF1330 PF07045.11 ACS99467.1 - 0.043 14.2 0.2 0.21 11.9 0.1 2.2 3 0 0 3 3 1 0 Domain of unknown function (DUF1330) Mg_chelatase PF01078.21 ACS99467.1 - 0.046 13.1 1.6 2.4 7.5 0.0 2.6 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 ACS99467.1 - 0.05 13.9 0.1 0.5 10.6 0.1 2.4 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ACS99467.1 - 0.051 13.7 0.0 0.84 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain RecA PF00154.21 ACS99467.1 - 0.081 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 recA bacterial DNA recombination protein AAA_14 PF13173.6 ACS99467.1 - 0.082 12.9 0.0 0.7 9.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ACS99467.1 - 0.097 12.6 0.7 0.76 9.6 0.1 2.6 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 ACS99467.1 - 0.13 12.4 0.3 0.53 10.4 0.1 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_24 PF13479.6 ACS99467.1 - 0.18 11.5 2.6 2.4 7.9 0.2 2.6 2 1 0 2 2 2 0 AAA domain FecCD PF01032.18 ACS99468.1 - 1.6e-100 336.1 28.2 2e-100 335.9 28.2 1.0 1 0 0 1 1 1 1 FecCD transport family SKG6 PF08693.10 ACS99468.1 - 3.1 7.3 6.4 1.7 8.1 0.4 3.2 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Peripla_BP_2 PF01497.18 ACS99469.1 - 9.7e-40 136.6 0.1 1.2e-39 136.4 0.1 1.1 1 0 0 1 1 1 1 Periplasmic binding protein NEAT PF05031.12 ACS99470.1 - 8.5e-34 116.7 0.4 1.3e-33 116.1 0.4 1.3 1 0 0 1 1 1 1 Iron Transport-associated domain DUF1180 PF06679.12 ACS99470.1 - 0.0016 18.9 4.0 0.0016 18.9 4.0 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1180) SYS1 PF09801.9 ACS99470.1 - 0.056 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Integral membrane protein S linking to the trans Golgi network SRP-alpha_N PF04086.13 ACS99470.1 - 2.4 8.0 10.1 3.7 7.4 10.1 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SLH PF00395.20 ACS99471.1 - 3.1e-41 139.1 3.7 1.4e-15 57.0 0.1 3.8 3 0 0 3 3 3 3 S-layer homology domain NEAT PF05031.12 ACS99471.1 - 7.4e-26 91.1 2.4 7.4e-26 91.1 2.4 3.7 4 0 0 4 4 4 1 Iron Transport-associated domain MctB PF11382.8 ACS99471.1 - 0.0001 22.2 19.0 0.15 11.7 1.8 3.3 3 0 0 3 3 3 3 Copper transport outer membrane protein, MctB DUF3577 PF12101.8 ACS99471.1 - 0.011 15.5 0.4 35 4.2 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3577) Vps62 PF06101.11 ACS99471.1 - 0.87 7.8 5.6 5.3 5.2 0.2 2.5 3 0 0 3 3 3 0 Vacuolar protein sorting-associated protein 62 BORCS7 PF16088.5 ACS99471.1 - 3.5 7.9 11.7 23 5.3 0.4 3.5 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 7 PFO_beta_C PF12367.8 ACS99471.1 - 3.7 7.8 4.9 68 3.7 0.1 3.5 3 0 0 3 3 3 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal GPP34 PF05719.11 ACS99471.1 - 4 7.4 18.8 3.8 7.5 0.1 3.4 3 0 0 3 3 3 0 Golgi phosphoprotein 3 (GPP34) FtsX_ECD PF18075.1 ACS99471.1 - 7 7.3 7.8 1e+02 3.6 0.2 3.4 3 0 0 3 3 3 0 FtsX extracellular domain Peripla_BP_2 PF01497.18 ACS99472.1 - 6.2e-43 147.1 0.5 7.4e-43 146.8 0.5 1.1 1 0 0 1 1 1 1 Periplasmic binding protein BLOC1_2 PF10046.9 ACS99472.1 - 0.097 13.0 0.5 0.4 11.0 0.1 2.2 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FecCD PF01032.18 ACS99473.1 - 1.5e-82 277.1 37.6 1.8e-82 276.8 37.6 1.0 1 0 0 1 1 1 1 FecCD transport family ABC_tran PF00005.27 ACS99474.1 - 2e-30 106.1 0.0 2.6e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS99474.1 - 4.3e-11 43.2 2.1 0.00013 21.9 0.5 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS99474.1 - 3e-08 33.4 0.1 3e-06 26.8 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACS99474.1 - 3.4e-06 26.7 0.1 7.6e-06 25.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 ACS99474.1 - 5.7e-05 22.8 0.2 0.0002 21.0 0.0 1.9 2 1 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 ACS99474.1 - 6.9e-05 21.8 1.4 0.13 11.0 0.5 3.4 2 2 1 3 3 3 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 ACS99474.1 - 0.0002 21.8 0.1 0.00043 20.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 ACS99474.1 - 0.00022 21.1 0.2 0.0014 18.4 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ACS99474.1 - 0.00062 19.7 0.1 0.0011 18.9 0.1 1.5 1 1 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 ACS99474.1 - 0.00089 19.8 0.3 0.0014 19.1 0.3 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ACS99474.1 - 0.0013 18.5 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACS99474.1 - 0.0025 18.1 0.6 0.021 15.1 0.6 2.1 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 ACS99474.1 - 0.02 14.8 0.2 0.094 12.6 0.0 2.0 2 0 0 2 2 2 0 Rad17 P-loop domain ATPase_2 PF01637.18 ACS99474.1 - 0.024 14.6 0.1 0.12 12.2 0.1 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 ACS99474.1 - 0.028 14.4 0.1 0.13 12.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 ACS99474.1 - 0.054 13.3 0.1 0.19 11.5 0.0 1.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 ACS99474.1 - 0.062 13.3 0.0 0.2 11.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ACS99474.1 - 0.087 13.1 0.0 0.23 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ACS99474.1 - 0.088 13.4 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ACS99474.1 - 0.11 12.3 0.0 0.35 10.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ACS99474.1 - 0.18 11.9 0.0 0.83 9.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ACS99474.1 - 0.24 11.7 0.7 1.2 9.5 0.4 2.2 1 1 0 1 1 1 0 AAA domain TPR_2 PF07719.17 ACS99476.1 - 0.0003 20.7 5.2 0.23 11.7 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat zinc_ribbon_2 PF13240.6 ACS99476.1 - 0.00042 19.9 0.4 0.00069 19.3 0.4 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 ACS99476.1 - 0.0043 17.0 0.9 0.0071 16.3 0.9 1.3 1 0 0 1 1 1 1 Double zinc ribbon TPR_14 PF13428.6 ACS99476.1 - 0.032 15.0 3.6 1.3 10.1 1.1 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat Gmad2 PF10648.9 ACS99476.1 - 0.068 13.4 0.2 0.3 11.4 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin-like domain of bacterial spore germination Elongin_A PF06881.11 ACS99476.1 - 0.11 13.0 1.5 0.26 11.8 1.5 1.7 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A NCE101 PF11654.8 ACS99476.1 - 0.11 12.2 0.3 0.23 11.2 0.3 1.5 1 0 0 1 1 1 0 Non-classical export protein 1 zinc_ribbon_15 PF17032.5 ACS99476.1 - 1.2 10.0 3.3 2.3 9.0 3.3 1.5 1 0 0 1 1 1 0 zinc-ribbon family Trypsin_2 PF13365.6 ACS99477.1 - 7.2e-29 101.6 3.1 2.6e-28 99.8 1.7 2.0 2 0 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.26 ACS99477.1 - 5e-13 49.4 0.4 2.7e-12 47.0 0.1 2.0 2 0 0 2 2 2 1 Trypsin Peptidase_A21 PF03566.13 ACS99478.1 - 0.11 10.7 0.0 0.12 10.6 0.0 1.0 1 0 0 1 1 1 0 Peptidase family A21 Myticin-prepro PF10690.9 ACS99479.1 - 0.16 12.2 8.1 0.24 11.7 8.1 1.2 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel Forkhead_N PF08430.12 ACS99479.1 - 0.29 11.8 2.8 0.4 11.3 2.8 1.3 1 0 0 1 1 1 0 Forkhead N-terminal region Sod_Fe_C PF02777.18 ACS99480.1 - 2.5e-39 133.6 0.0 3.7e-39 133.0 0.0 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ACS99480.1 - 5.6e-31 106.9 1.1 9.3e-31 106.1 1.1 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Acetyltransf_1 PF00583.25 ACS99481.1 - 1.9e-19 70.0 0.1 2.3e-19 69.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACS99481.1 - 3.2e-18 65.9 0.0 3.6e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACS99481.1 - 3.3e-14 53.1 0.1 4.7e-14 52.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACS99481.1 - 1.8e-07 31.0 0.0 2.7e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ACS99481.1 - 1.8e-07 31.3 0.2 6.7e-06 26.2 0.2 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 ACS99481.1 - 2.1e-06 28.0 0.0 2.8e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACS99481.1 - 2.8e-05 24.3 0.1 3.2e-05 24.1 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACS99481.1 - 0.00036 21.2 0.0 0.00043 21.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACS99481.1 - 0.00091 19.3 0.0 0.0014 18.7 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 ACS99481.1 - 0.0014 18.6 0.1 0.0081 16.1 0.1 2.0 2 0 0 2 2 2 1 ESCO1/2 acetyl-transferase Acetyltransf_8 PF13523.6 ACS99481.1 - 0.0046 16.6 0.0 0.0082 15.8 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltr_2 PF13718.6 ACS99481.1 - 0.0079 15.6 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase 2 GNAT_acetyltran PF12746.7 ACS99481.1 - 0.012 15.2 0.0 0.026 14.1 0.0 1.4 1 1 0 1 1 1 0 GNAT acetyltransferase DUF3760 PF12586.8 ACS99481.1 - 0.41 10.9 2.6 3.9 7.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3760) DUF402 PF04167.13 ACS99482.1 - 1.8e-16 60.1 0.5 4.5e-16 58.8 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF402) Peptidase_S24 PF00717.23 ACS99483.1 - 1.4e-14 53.8 0.0 2.6e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 ACS99483.1 - 7.6e-12 45.2 0.0 1e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 RNase_H PF00075.24 ACS99484.1 - 1.2e-44 152.0 0.0 1.3e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 ACS99484.1 - 0.0078 16.0 0.0 0.087 12.6 0.0 2.2 1 1 0 1 1 1 1 Reverse transcriptase-like Endonuc-BglII PF09195.11 ACS99484.1 - 0.091 12.6 0.9 0.12 12.2 0.9 1.2 1 0 0 1 1 1 0 Restriction endonuclease BglII AAA_12 PF13087.6 ACS99484.1 - 0.13 11.8 0.0 0.22 11.1 0.0 1.3 1 1 0 1 1 1 0 AAA domain DUF1730 PF08331.10 ACS99485.1 - 1.6e-21 75.9 0.0 3.3e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1730) Fer4_16 PF13484.6 ACS99485.1 - 5.2e-17 62.5 5.8 1e-16 61.6 5.8 1.5 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain HEAT_2 PF13646.6 ACS99485.1 - 9.9e-12 45.1 0.1 2.9e-11 43.6 0.1 1.8 1 0 0 1 1 1 1 HEAT repeats HEAT_PBS PF03130.16 ACS99485.1 - 1.4e-08 34.6 3.2 0.0015 19.0 1.0 3.2 3 0 0 3 3 3 2 PBS lyase HEAT-like repeat Fer4_10 PF13237.6 ACS99485.1 - 7.9e-07 29.1 3.1 0.0032 17.6 1.0 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 ACS99485.1 - 1.2e-05 25.8 7.0 3.1e-05 24.5 7.0 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 ACS99485.1 - 0.00018 21.6 4.7 0.017 15.3 0.6 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 ACS99485.1 - 0.00092 19.3 10.0 0.016 15.3 10.0 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 ACS99485.1 - 0.0019 17.9 16.5 0.0094 15.7 4.1 2.8 3 0 0 3 3 3 2 4Fe-4S binding domain HEAT_EZ PF13513.6 ACS99485.1 - 0.004 17.6 0.1 0.004 17.6 0.1 3.1 4 1 0 4 4 4 1 HEAT-like repeat Fer4_2 PF12797.7 ACS99485.1 - 0.022 14.8 15.5 0.72 10.1 5.2 3.0 3 0 0 3 3 3 0 4Fe-4S binding domain SCIFF PF13165.6 ACS99485.1 - 0.027 14.4 3.7 1.1 9.3 0.7 2.4 2 0 0 2 2 2 0 Six-cysteine peptide SCIFF Fer4_8 PF13183.6 ACS99485.1 - 0.044 14.2 8.7 0.61 10.6 8.9 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 ACS99485.1 - 0.056 13.5 15.4 0.39 10.9 4.3 2.6 2 1 0 2 2 2 0 4Fe-4S binding domain Fer4_3 PF12798.7 ACS99485.1 - 0.1 13.6 12.2 1.7 9.8 2.9 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain UPF0154 PF03672.13 ACS99486.1 - 3.5e-17 62.2 7.9 4.2e-17 61.9 7.9 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0154) DUF3552 PF12072.8 ACS99486.1 - 0.00051 19.5 0.0 0.00061 19.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) Helicase_PWI PF18149.1 ACS99486.1 - 0.0059 16.8 0.3 0.0073 16.5 0.3 1.2 1 0 0 1 1 1 1 N-terminal helicase PWI domain MSC PF09402.10 ACS99486.1 - 0.0097 15.4 0.0 0.01 15.3 0.0 1.0 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain DivIC PF04977.15 ACS99486.1 - 0.026 14.3 0.9 0.048 13.4 0.1 1.8 1 1 1 2 2 2 0 Septum formation initiator DrsE_2 PF13686.6 ACS99486.1 - 0.081 12.8 3.8 0.096 12.6 3.8 1.0 1 0 0 1 1 1 0 DsrE/DsrF/DrsH-like family LapA_dom PF06305.11 ACS99486.1 - 1.2 9.0 4.5 3.8 7.4 4.5 1.8 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain GTP_cyclohydroI PF01227.22 ACS99487.1 - 7.9e-77 256.7 0.2 8.9e-77 256.5 0.2 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 ACS99487.1 - 0.0013 18.9 0.0 0.0084 16.2 0.0 2.0 2 0 0 2 2 2 1 QueF-like protein DUF3638 PF12340.8 ACS99487.1 - 0.04 13.3 0.0 0.063 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) Abhydrolase_1 PF00561.20 ACS99488.1 - 2.4e-12 47.0 0.2 4.8e-08 33.0 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ACS99488.1 - 1.6e-09 37.4 0.1 2.2e-05 23.9 0.1 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 ACS99488.1 - 8e-09 35.6 0.2 0.003 17.4 0.1 3.3 1 1 1 3 3 3 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 ACS99488.1 - 8e-09 36.4 0.2 2.9e-07 31.3 0.0 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.18 ACS99488.1 - 0.0013 18.3 0.1 0.017 14.7 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family DUF3530 PF12048.8 ACS99488.1 - 0.0015 18.0 0.1 0.0025 17.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3530) Abhydrolase_3 PF07859.13 ACS99488.1 - 0.0043 16.9 0.3 0.03 14.2 0.1 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ACS99488.1 - 0.012 15.1 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Lipase PF00151.19 ACS99488.1 - 0.013 14.9 0.0 0.017 14.4 0.0 1.1 1 0 0 1 1 1 0 Lipase LIP PF03583.14 ACS99488.1 - 0.03 13.7 0.2 0.37 10.1 0.1 2.1 2 0 0 2 2 2 0 Secretory lipase Esterase PF00756.20 ACS99488.1 - 0.087 12.5 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Putative esterase FixQ PF05545.11 ACS99488.1 - 0.81 9.7 6.0 1.7 8.7 6.0 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ IclR PF01614.18 ACS99489.1 - 5.5e-24 84.4 0.0 1.3e-23 83.2 0.0 1.6 1 1 0 1 1 1 1 Bacterial transcriptional regulator HTH_IclR PF09339.10 ACS99489.1 - 2.2e-19 69.0 0.0 4.6e-19 67.9 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain MarR_2 PF12802.7 ACS99489.1 - 3.7e-09 36.3 0.1 8.8e-09 35.1 0.1 1.6 1 0 0 1 1 1 1 MarR family MarR PF01047.22 ACS99489.1 - 5.6e-08 32.6 0.0 1.1e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACS99489.1 - 1.4e-06 27.8 0.0 2.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 ACS99489.1 - 1.8e-06 27.8 0.0 6.2e-06 26.0 0.0 1.8 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB LexA_DNA_bind PF01726.16 ACS99489.1 - 1.9e-05 24.4 0.0 5.4e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 LexA DNA binding domain HTH_20 PF12840.7 ACS99489.1 - 0.00022 21.2 0.7 0.00048 20.1 0.1 2.0 2 0 0 2 2 1 1 Helix-turn-helix domain HTH_5 PF01022.20 ACS99489.1 - 0.00025 20.8 0.0 0.00055 19.7 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family Fe_dep_repress PF01325.19 ACS99489.1 - 0.00042 20.5 0.0 0.0058 16.8 0.0 2.4 3 0 0 3 3 2 1 Iron dependent repressor, N-terminal DNA binding domain HTH_Crp_2 PF13545.6 ACS99489.1 - 0.00048 20.1 0.0 0.0012 18.8 0.0 1.7 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 ACS99489.1 - 0.00049 20.4 0.0 0.0015 18.9 0.0 1.8 2 0 0 2 2 1 1 Transcriptional regulator HTH_23 PF13384.6 ACS99489.1 - 0.00083 19.1 0.2 0.0037 17.0 0.0 2.2 3 0 0 3 3 2 1 Homeodomain-like domain HTH_11 PF08279.12 ACS99489.1 - 0.0015 18.5 0.0 0.003 17.4 0.0 1.5 1 0 0 1 1 1 1 HTH domain HTH_AsnC-type PF13404.6 ACS99489.1 - 0.0054 16.5 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_CodY PF08222.11 ACS99489.1 - 0.0078 15.7 0.0 0.017 14.6 0.0 1.6 2 0 0 2 2 1 1 CodY helix-turn-helix domain GntR PF00392.21 ACS99489.1 - 0.0094 15.6 0.0 0.024 14.3 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_27 PF13463.6 ACS99489.1 - 0.013 16.0 0.0 0.026 15.0 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_36 PF13730.6 ACS99489.1 - 0.022 14.7 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_38 PF13936.6 ACS99489.1 - 0.043 13.6 0.1 0.24 11.2 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Penicillinase_R PF03965.16 ACS99489.1 - 0.044 14.2 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 Penicillinase repressor Sigma54_DBD PF04552.13 ACS99489.1 - 0.044 13.5 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Sigma-54, DNA binding domain HTH_Tnp_ISL3 PF13542.6 ACS99489.1 - 0.05 13.0 0.0 0.13 11.6 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 SseB_C PF14581.6 ACS99489.1 - 0.056 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 SseB protein C-terminal domain UPF0122 PF04297.14 ACS99489.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like FaeA PF04703.12 ACS99489.1 - 0.13 12.6 0.0 0.31 11.4 0.0 1.6 1 0 0 1 1 1 0 FaeA-like protein FeoC PF09012.10 ACS99489.1 - 0.15 12.2 0.1 0.71 10.0 0.0 2.1 2 0 0 2 2 2 0 FeoC like transcriptional regulator Aconitase PF00330.20 ACS99490.1 - 1.7e-181 604.3 0.0 2.3e-181 603.8 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ACS99490.1 - 2.7e-47 160.4 0.0 5.7e-47 159.3 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF3060 PF11259.8 ACS99490.1 - 0.13 12.0 0.7 0.33 10.7 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3060) Amidase_6 PF12671.7 ACS99491.1 - 8.1e-33 113.9 7.8 1.3e-32 113.2 7.8 1.3 1 0 0 1 1 1 1 Putative amidase domain CHAP PF05257.16 ACS99491.1 - 0.0092 16.5 1.3 0.035 14.7 1.3 2.0 1 0 0 1 1 1 1 CHAP domain DUF3220 PF11516.8 ACS99491.1 - 0.018 15.3 0.1 2 8.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3120) Dala_Dala_lig_C PF07478.13 ACS99492.1 - 9.1e-77 257.2 0.0 1.1e-76 256.9 0.0 1.1 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Dala_Dala_lig_N PF01820.21 ACS99492.1 - 3e-26 91.9 0.0 7.8e-26 90.5 0.0 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase N-terminus ATP-grasp PF02222.22 ACS99492.1 - 8.8e-10 38.4 0.0 1.4e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 ACS99492.1 - 8.5e-08 31.9 0.0 1.4e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 ACS99492.1 - 0.00011 21.8 0.1 0.00063 19.4 0.1 2.1 1 1 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 ACS99492.1 - 0.0071 16.0 0.0 0.023 14.3 0.0 1.7 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 ACS99492.1 - 0.009 16.1 0.0 0.016 15.2 0.0 1.4 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 ACS99492.1 - 0.015 15.0 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain UvdE PF03851.14 ACS99494.1 - 8.9e-76 254.7 0.0 1.1e-75 254.4 0.0 1.1 1 0 0 1 1 1 1 UV-endonuclease UvdE TauE PF01925.19 ACS99495.1 - 3.3e-47 161.1 43.8 4.1e-47 160.8 43.8 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Inositol_P PF00459.25 ACS99496.1 - 6e-64 216.2 0.0 7.8e-64 215.8 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family SLH PF00395.20 ACS99497.1 - 1.5e-42 143.4 0.4 2.3e-15 56.3 0.0 3.7 3 0 0 3 3 3 3 S-layer homology domain Flg_new PF09479.10 ACS99497.1 - 3.9e-35 119.8 69.7 0.00012 22.2 1.2 11.1 10 0 0 10 10 10 10 Listeria-Bacteroides repeat domain (List_Bact_rpt) F5_F8_type_C PF00754.25 ACS99497.1 - 0.93 9.6 15.9 0.2 11.8 0.3 4.5 4 1 1 5 5 5 0 F5/8 type C domain Response_reg PF00072.24 ACS99498.1 - 7.8e-28 96.9 0.1 1.5e-27 95.9 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99498.1 - 3.1e-18 65.8 0.0 1.2e-17 63.9 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99498.1 - 4e-16 58.6 0.3 3.1e-08 33.5 0.0 2.9 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family PP2C_2 PF13672.6 ACS99498.1 - 0.022 14.4 0.1 0.057 13.1 0.1 1.7 1 1 0 1 1 1 0 Protein phosphatase 2C MitMem_reg PF13012.6 ACS99498.1 - 0.14 12.6 0.2 0.86 10.0 0.0 2.2 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function NPV_P10 PF05531.12 ACS99498.1 - 0.14 12.6 0.0 4.2 7.9 0.0 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein His_kinase PF06580.13 ACS99499.1 - 1.1e-19 70.5 2.9 1.1e-19 70.5 2.9 1.9 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACS99499.1 - 1.7e-07 31.3 3.1 1.7e-07 31.3 3.1 1.5 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACS99499.1 - 5.3e-05 23.7 0.0 0.00013 22.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACS99499.1 - 0.00076 19.8 0.0 0.0022 18.4 0.0 1.9 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 ACS99499.1 - 0.025 14.4 0.0 0.069 13.0 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BPD_transp_1 PF00528.22 ACS99500.1 - 8.3e-13 48.5 13.5 3.3e-12 46.5 10.6 2.2 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component Cation_ATPase_C PF00689.21 ACS99500.1 - 0.22 11.2 0.0 0.22 11.2 0.0 3.0 3 1 0 3 3 3 0 Cation transporting ATPase, C-terminus BPD_transp_1 PF00528.22 ACS99501.1 - 7.5e-16 58.4 12.0 7.5e-16 58.4 12.0 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component ATP1G1_PLM_MAT8 PF02038.16 ACS99501.1 - 0.12 11.8 1.5 0.26 10.8 1.5 1.4 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family SBP_bac_1 PF01547.25 ACS99502.1 - 3.9e-21 76.3 19.9 3.9e-21 76.3 19.9 1.8 1 1 0 2 2 2 1 Bacterial extracellular solute-binding protein CRAL_TRIO PF00650.20 ACS99502.1 - 0.053 13.2 0.3 0.12 12.1 0.1 1.6 2 0 0 2 2 2 0 CRAL/TRIO domain CBM_4_9 PF02018.17 ACS99503.1 - 2e-93 310.0 46.9 2.2e-13 50.6 1.4 10.0 10 0 0 10 10 10 8 Carbohydrate binding domain Glyco_hydro_16 PF00722.21 ACS99503.1 - 1.3e-63 213.7 9.0 1.4e-31 109.4 1.4 2.6 2 0 0 2 2 2 2 Glycosyl hydrolases family 16 DUF1533 PF07550.11 ACS99503.1 - 5e-61 202.5 3.2 2e-14 53.2 0.0 6.0 4 0 0 4 4 4 4 Protein of unknown function (DUF1533) F5_F8_type_C PF00754.25 ACS99503.1 - 2.5e-36 124.6 20.1 1.8e-19 70.1 3.2 5.1 5 0 0 5 5 4 2 F5/8 type C domain SLH PF00395.20 ACS99503.1 - 3.3e-34 116.6 1.4 3.7e-14 52.4 0.7 3.9 3 0 0 3 3 3 3 S-layer homology domain SKN1 PF03935.15 ACS99503.1 - 1.2e-24 86.7 15.9 5.8e-07 28.3 2.3 4.4 4 0 0 4 4 4 4 Beta-glucan synthesis-associated protein (SKN1) DUF642 PF04862.12 ACS99503.1 - 3e-05 23.8 6.5 0.59 9.9 0.0 6.8 7 0 0 7 7 7 1 Protein of unknown function (DUF642) CBM_X2 PF03442.14 ACS99503.1 - 0.0011 19.1 16.6 0.092 12.9 0.1 7.1 7 0 0 7 7 7 1 Carbohydrate binding domain X2 Tail_tube PF10618.9 ACS99503.1 - 0.014 15.3 1.8 0.72 9.8 0.0 4.5 5 0 0 5 5 5 0 Phage tail tube protein DUF4082 PF13313.6 ACS99503.1 - 0.015 15.4 16.3 0.22 11.6 0.2 6.7 8 0 0 8 8 8 0 Domain of unknown function (DUF4082) DEC-1_N PF04625.13 ACS99503.1 - 0.052 12.6 0.9 0.093 11.7 0.9 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF5604 PF18300.1 ACS99503.1 - 0.064 13.2 0.3 7.5 6.6 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5604) Calx-beta PF03160.14 ACS99503.1 - 0.066 13.4 5.8 5.7 7.2 0.0 5.2 6 0 0 6 6 5 0 Calx-beta domain CarboxypepD_reg PF13620.6 ACS99503.1 - 2.7 8.3 16.0 4.7 7.5 0.2 6.6 6 0 0 6 6 6 0 Carboxypeptidase regulatory-like domain Aminotran_3 PF00202.21 ACS99504.1 - 1.4e-68 231.5 0.1 1.6e-68 231.2 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III LytR_cpsA_psr PF03816.14 ACS99505.1 - 1.3e-43 148.8 0.2 1.7e-43 148.4 0.2 1.2 1 0 0 1 1 1 1 Cell envelope-related transcriptional attenuator domain ABC_tran PF00005.27 ACS99506.1 - 6.4e-27 94.7 0.0 1.5e-26 93.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS99506.1 - 1e-11 45.2 4.1 1.1e-09 38.6 0.5 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACS99506.1 - 0.0028 17.4 0.0 0.0054 16.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ACS99506.1 - 0.0056 16.4 0.3 1.5 8.4 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 ACS99506.1 - 0.023 15.2 0.3 0.048 14.2 0.3 1.8 1 1 0 1 1 1 0 AAA domain Ribosomal_60s PF00428.19 ACS99506.1 - 0.033 14.8 1.8 0.059 14.0 1.8 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein RsgA_GTPase PF03193.16 ACS99506.1 - 0.17 11.8 0.1 0.32 10.9 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ACS99506.1 - 0.33 11.2 1.6 2.3 8.5 1.6 2.4 1 1 0 1 1 1 0 AAA domain ABC2_membrane_6 PF06182.11 ACS99507.1 - 2.2e-22 80.0 16.5 2.2e-22 80.0 16.5 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 ACS99507.1 - 0.00031 20.2 20.5 0.00031 20.2 20.5 1.6 1 1 1 2 2 2 1 ABC-2 type transporter SPECT1 PF18680.1 ACS99507.1 - 0.027 14.1 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 Plasmodium host cell traversal SPECT1 ATP-synt_8 PF00895.20 ACS99507.1 - 0.045 14.2 0.9 0.045 14.2 0.9 2.2 2 0 0 2 2 2 0 ATP synthase protein 8 ABC2_membrane_3 PF12698.7 ACS99507.1 - 6.5 5.7 28.9 0.7 8.9 19.9 2.6 1 1 1 2 2 2 0 ABC-2 family transporter protein ABC2_membrane_6 PF06182.11 ACS99508.1 - 3.7e-48 164.3 14.2 4.3e-48 164.1 14.2 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein Tetraspanin PF00335.20 ACS99508.1 - 1.6 8.4 9.8 26 4.4 0.1 3.0 2 1 0 3 3 3 0 Tetraspanin family Trp_oprn_chp PF09534.10 ACS99508.1 - 3 7.6 4.5 2.5 7.8 1.2 2.0 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3040 PF11239.8 ACS99508.1 - 5.5 7.3 11.2 0.62 10.4 0.9 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3040) DUF3185 PF11381.8 ACS99508.1 - 9.5 6.3 8.4 1.3 9.0 0.5 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) AhpC-TSA PF00578.21 ACS99509.1 - 1.8e-41 141.0 0.0 2.1e-41 140.7 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ACS99509.1 - 1.2e-26 93.2 0.0 1.4e-26 93.0 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 ACS99509.1 - 0.075 13.2 0.0 0.28 11.3 0.0 1.8 1 1 0 1 1 1 0 AhpC/TSA antioxidant enzyme Thioredoxin_8 PF13905.6 ACS99509.1 - 0.088 13.1 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like Polysacc_deac_1 PF01522.21 ACS99510.1 - 3.8e-29 101.1 0.1 1.3e-28 99.3 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide deacetylase DUF2334 PF10096.9 ACS99510.1 - 0.065 12.9 0.1 0.6 9.7 0.0 2.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2334) DUF737 PF05300.11 ACS99510.1 - 0.17 12.2 0.1 0.33 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF737) AAA_3 PF07726.11 ACS99511.1 - 4.5e-58 194.8 0.0 7.5e-58 194.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ACS99511.1 - 1.7e-17 63.7 0.0 3.9e-17 62.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 ACS99511.1 - 1.6e-14 53.5 1.1 3.5e-14 52.4 1.1 1.6 1 0 0 1 1 1 1 AAA lid domain AAA PF00004.29 ACS99511.1 - 2.9e-06 27.7 0.0 8.1e-06 26.3 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ACS99511.1 - 2.8e-05 23.6 0.8 0.023 14.1 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 ACS99511.1 - 9.8e-05 22.1 0.1 0.0016 18.2 0.1 2.4 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 ACS99511.1 - 0.00017 21.4 0.2 0.0098 15.6 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain MCM PF00493.23 ACS99511.1 - 0.00025 20.2 0.0 0.00036 19.7 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain DUF58 PF01882.18 ACS99512.1 - 1.2e-09 38.3 0.1 3.2e-09 36.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function DUF58 Transglut_core PF01841.19 ACS99513.1 - 7.6e-29 100.4 0.0 1.9e-28 99.2 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily SNARE PF05739.19 ACS99513.1 - 0.01 15.8 1.6 0.046 13.7 0.2 2.4 2 0 0 2 2 2 0 SNARE domain Polysacc_deac_1 PF01522.21 ACS99514.1 - 2.6e-33 114.6 0.0 4.1e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ACS99514.1 - 0.015 14.6 0.0 0.023 13.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 CBM64 PF18666.1 ACS99514.1 - 0.027 14.5 0.3 0.054 13.6 0.3 1.4 1 0 0 1 1 1 0 Carbohydrate-binding module 64 GMP_synt_C PF00958.22 ACS99515.1 - 1.5e-44 150.0 0.2 3.3e-44 148.8 0.2 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 ACS99515.1 - 1.7e-39 135.6 0.0 2.4e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 ACS99515.1 - 7.8e-12 44.8 0.1 3.9e-08 32.7 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 ACS99515.1 - 1.6e-11 44.4 0.0 5.4e-11 42.7 0.0 1.9 1 1 1 2 2 2 1 Peptidase C26 tRNA_Me_trans PF03054.16 ACS99515.1 - 2e-05 23.5 0.3 0.00013 20.9 0.1 2.3 3 0 0 3 3 3 1 tRNA methyl transferase QueC PF06508.13 ACS99515.1 - 0.00014 21.5 0.1 0.0068 15.9 0.1 2.2 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 ACS99515.1 - 0.0002 21.1 0.0 0.00054 19.7 0.0 1.6 2 0 0 2 2 2 1 Asparagine synthase ATP_bind_3 PF01171.20 ACS99515.1 - 0.0022 17.8 0.0 0.0034 17.2 0.0 1.3 1 0 0 1 1 1 1 PP-loop family GATase_3 PF07685.14 ACS99515.1 - 0.041 13.5 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain ThiI PF02568.14 ACS99515.1 - 0.044 13.4 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.19 ACS99515.1 - 0.13 11.6 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase HTH_18 PF12833.7 ACS99516.1 - 7.4e-21 74.2 0.1 2.8e-20 72.4 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99516.1 - 1.6e-13 50.4 0.1 3.3e-06 27.0 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Glyco_hydro_3_C PF01915.22 ACS99517.1 - 8.8e-59 198.9 0.0 1.7e-58 198.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ACS99517.1 - 2.3e-51 175.1 0.0 4.2e-51 174.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ACS99517.1 - 7.7e-26 90.0 0.3 1.6e-25 89.0 0.3 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF11 PF01345.18 ACS99517.1 - 0.0022 18.3 1.3 1.2 9.4 0.2 2.8 2 1 0 2 2 2 2 Domain of unknown function DUF11 CARDB PF07705.11 ACS99517.1 - 0.051 13.8 0.4 0.14 12.4 0.2 1.9 1 1 0 1 1 1 0 CARDB Usp PF00582.26 ACS99517.1 - 0.082 13.4 0.5 3.7 8.1 0.1 2.5 2 0 0 2 2 2 0 Universal stress protein family AP_endonuc_2 PF01261.24 ACS99518.1 - 1.2e-14 54.2 0.0 1.7e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel GFO_IDH_MocA PF01408.22 ACS99519.1 - 2e-29 102.8 0.1 3.4e-29 102.1 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACS99519.1 - 5.8e-08 32.7 0.0 2e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACS99519.1 - 0.0058 17.3 0.1 0.011 16.4 0.1 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Corona_NS2A PF05213.12 ACS99519.1 - 0.0063 15.9 0.0 0.0092 15.4 0.0 1.1 1 0 0 1 1 1 1 Coronavirus NS2A protein His_kinase PF06580.13 ACS99520.1 - 5.1e-18 65.2 2.2 5.1e-18 65.2 2.2 1.8 2 0 0 2 2 2 1 Histidine kinase HAMP PF00672.25 ACS99520.1 - 5.2e-10 39.6 0.1 1.1e-09 38.6 0.1 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACS99520.1 - 2.2e-08 34.6 0.1 4.3e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ACS99521.1 - 2.5e-24 85.6 0.1 1.9e-23 82.8 0.0 2.5 3 0 0 3 3 3 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99521.1 - 1.3e-20 73.4 0.0 3.4e-20 72.1 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99521.1 - 1.6e-14 53.5 0.0 1.6e-07 31.3 0.0 3.0 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Crp PF00325.20 ACS99521.1 - 0.033 13.8 0.0 0.093 12.4 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family HTH_3 PF01381.22 ACS99521.1 - 0.13 12.3 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix BPD_transp_1 PF00528.22 ACS99522.1 - 5e-17 62.2 13.7 5e-17 62.2 13.7 1.9 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99523.1 - 1.3e-12 47.8 29.8 2.6e-11 43.6 29.8 2.3 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF3502 PF12010.8 ACS99524.1 - 8.3e-47 159.1 1.5 8.3e-47 159.1 1.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACS99524.1 - 5.2e-13 49.6 2.5 5.2e-13 49.6 2.5 1.8 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein Glyco_hydro_3 PF00933.21 ACS99525.1 - 3e-35 122.1 0.0 5.2e-35 121.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ACS99525.1 - 8e-15 55.3 0.2 3.6e-14 53.2 0.0 2.2 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain SLH PF00395.20 ACS99526.1 - 2.9e-35 120.0 5.7 2.1e-13 50.0 0.2 3.7 3 0 0 3 3 3 3 S-layer homology domain ZU5 PF00791.20 ACS99526.1 - 0.0094 16.3 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 1 ZU5 domain HTH_18 PF12833.7 ACS99527.1 - 1.1e-21 76.9 0.0 2.5e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99527.1 - 4e-17 61.8 0.0 7.9e-08 32.2 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99527.1 - 3.2e-12 46.5 0.1 5.1e-12 45.9 0.1 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99527.1 - 8.4e-07 28.6 0.0 1.4e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Ectoine_synth PF06339.12 ACS99527.1 - 0.015 15.5 0.0 0.025 14.8 0.0 1.3 1 0 0 1 1 1 0 Ectoine synthase BcrAD_BadFG PF01869.20 ACS99528.1 - 4.4e-29 101.8 1.3 5.2e-29 101.5 1.3 1.1 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family ROK PF00480.20 ACS99528.1 - 0.0022 17.5 0.1 0.53 9.7 0.0 2.4 3 0 0 3 3 3 2 ROK family FGGY_N PF00370.21 ACS99528.1 - 0.013 15.1 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Ketoacyl-synt_C PF02801.22 ACS99528.1 - 0.023 14.7 0.2 0.33 11.0 0.0 2.2 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain Glyco_hydro_4 PF02056.16 ACS99529.1 - 3.8e-68 228.6 0.0 7.6e-68 227.7 0.0 1.5 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase Glyco_hydro_4C PF11975.8 ACS99529.1 - 6.3e-48 163.6 0.0 1.2e-47 162.7 0.0 1.4 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase C-terminal domain Ldh_1_N PF00056.23 ACS99529.1 - 0.00039 20.5 0.0 0.0073 16.4 0.0 2.2 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Xan_ur_permease PF00860.20 ACS99530.1 - 4.3e-41 140.9 55.3 1.1e-40 139.6 54.3 2.0 1 1 0 1 1 1 1 Permease family NAGPA PF09992.9 ACS99531.1 - 1.6e-36 126.0 1.1 2.4e-36 125.5 0.1 1.7 2 0 0 2 2 2 1 Phosphodiester glycosidase DUF5305 PF17231.2 ACS99532.1 - 6.2e-05 22.5 1.0 6.9e-05 22.4 0.4 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF5305) HemX PF04375.14 ACS99532.1 - 0.0007 19.0 4.0 0.00093 18.6 4.0 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase DUF3402 PF11882.8 ACS99532.1 - 0.0032 16.6 2.1 0.0033 16.6 2.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) Phage_Mu_Gam PF07352.12 ACS99532.1 - 0.0053 16.7 5.7 0.025 14.5 5.7 2.0 1 1 0 1 1 1 1 Bacteriophage Mu Gam like protein DUF3810 PF12725.7 ACS99532.1 - 0.024 14.0 4.2 0.039 13.3 4.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) Z1 PF10593.9 ACS99532.1 - 0.033 13.7 1.9 0.039 13.4 1.9 1.1 1 0 0 1 1 1 0 Z1 domain PAP_PilO PF06864.12 ACS99532.1 - 0.035 13.0 0.5 0.044 12.6 0.5 1.2 1 0 0 1 1 1 0 Pilin accessory protein (PilO) MerR-DNA-bind PF09278.11 ACS99532.1 - 0.039 14.5 1.9 0.57 10.8 0.0 2.4 1 1 2 3 3 3 0 MerR, DNA binding Ctr PF04145.15 ACS99532.1 - 0.04 14.5 0.3 0.06 14.0 0.3 1.4 1 1 0 1 1 1 0 Ctr copper transporter family Baculo_PEP_C PF04513.12 ACS99532.1 - 0.047 13.7 5.2 0.35 10.9 0.5 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sterile PF03015.19 ACS99532.1 - 0.065 13.5 0.2 0.11 12.7 0.2 1.4 1 0 0 1 1 1 0 Male sterility protein TRPM_tetra PF16519.5 ACS99532.1 - 0.072 13.2 4.3 2.3 8.4 0.5 2.2 1 1 1 2 2 2 0 Tetramerisation domain of TRPM Flagellin_N PF00669.20 ACS99532.1 - 0.092 12.8 5.7 0.16 12.0 5.7 1.4 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region WXG100 PF06013.12 ACS99532.1 - 0.093 13.0 3.5 0.62 10.3 3.5 2.1 1 1 0 1 1 1 0 Proteins of 100 residues with WXG Mt_ATP-synt_D PF05873.12 ACS99532.1 - 0.12 12.2 6.1 0.096 12.5 1.8 2.1 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) FapA PF03961.13 ACS99532.1 - 0.12 10.9 6.4 0.15 10.6 6.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 ACS99532.1 - 0.16 11.5 3.7 0.15 11.6 3.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Allexi_40kDa PF05549.11 ACS99532.1 - 0.22 11.0 3.5 0.31 10.5 3.3 1.4 1 1 0 1 1 1 0 Allexivirus 40kDa protein KxDL PF10241.9 ACS99532.1 - 0.31 11.3 10.5 1.4 9.3 5.1 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein zf-C4H2 PF10146.9 ACS99532.1 - 0.35 11.1 7.6 0.47 10.7 7.6 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein DUF16 PF01519.16 ACS99532.1 - 0.38 11.3 9.0 0.54 10.8 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 APG6_N PF17675.1 ACS99532.1 - 0.41 11.2 10.3 0.68 10.5 10.3 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region ABC_tran_CTD PF16326.5 ACS99532.1 - 0.49 10.7 10.1 0.52 10.6 3.9 2.8 1 1 1 2 2 2 0 ABC transporter C-terminal domain DUF1664 PF07889.12 ACS99532.1 - 0.53 10.3 5.2 1.2 9.2 5.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 ACS99532.1 - 0.62 10.5 5.8 3.9 8.0 0.3 2.8 1 1 0 2 2 2 0 Flagella accessory protein C (FlaC) XhlA PF10779.9 ACS99532.1 - 0.62 10.3 8.0 5.8 7.2 0.5 2.7 1 1 1 2 2 2 0 Haemolysin XhlA DUF948 PF06103.11 ACS99532.1 - 0.89 9.9 8.8 90 3.4 8.8 2.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Fzo_mitofusin PF04799.13 ACS99532.1 - 1.1 8.8 8.2 2.8 7.5 7.0 2.0 1 1 0 1 1 1 0 fzo-like conserved region DUF724 PF05266.14 ACS99532.1 - 1.2 8.9 8.6 1.9 8.3 2.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 ACS99532.1 - 1.2 8.4 10.6 1.2 8.5 9.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1690 PF07956.11 ACS99532.1 - 1.3 9.4 10.7 3.2 8.2 10.7 1.6 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) PCRF PF03462.18 ACS99532.1 - 1.5 8.7 7.2 2.2 8.1 7.2 1.2 1 0 0 1 1 1 0 PCRF domain DUF2115 PF09888.9 ACS99532.1 - 2.3 8.7 6.9 1.2 9.6 4.5 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) NPV_P10 PF05531.12 ACS99532.1 - 2.8 8.5 8.9 1.4 9.4 3.8 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1043 PF06295.12 ACS99532.1 - 3.7 7.6 10.3 7.3 6.6 2.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) PMSR PF01625.21 ACS99533.1 - 1e-61 207.6 0.2 1.5e-61 207.1 0.2 1.2 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase SelR PF01641.18 ACS99533.1 - 1.2e-49 167.3 0.0 2.3e-49 166.5 0.0 1.5 1 0 0 1 1 1 1 SelR domain Nitroreductase PF00881.24 ACS99534.1 - 9.2e-29 100.7 0.0 1.1e-28 100.4 0.0 1.0 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 ACS99534.1 - 4.2e-07 29.8 0.0 0.0027 17.3 0.0 2.3 2 0 0 2 2 2 2 Putative TM nitroreductase MarR PF01047.22 ACS99535.1 - 5.1e-18 64.7 0.0 7.4e-18 64.2 0.0 1.3 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACS99535.1 - 8.5e-13 48.0 0.1 1.2e-12 47.5 0.1 1.2 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACS99535.1 - 1.5e-05 24.4 0.0 2.3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_27 PF13463.6 ACS99535.1 - 5e-05 23.7 0.1 7.5e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_34 PF13601.6 ACS99535.1 - 9.7e-05 22.5 0.0 0.00014 22.0 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_5 PF01022.20 ACS99535.1 - 0.0018 18.1 0.1 0.0068 16.2 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family YbjN PF10722.9 ACS99535.1 - 0.0049 16.9 0.0 0.0079 16.2 0.0 1.3 1 0 0 1 1 1 1 Putative bacterial sensory transduction regulator HTH_Crp_2 PF13545.6 ACS99535.1 - 0.0052 16.7 0.3 0.0097 15.9 0.1 1.7 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain RuvB_C PF05491.13 ACS99535.1 - 0.019 14.8 0.1 0.098 12.5 0.1 2.0 2 0 0 2 2 2 0 RuvB C-terminal winged helix domain TrmB PF01978.19 ACS99535.1 - 0.024 14.5 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 ACS99535.1 - 0.029 14.2 0.1 0.05 13.4 0.1 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain ComR_TPR PF18710.1 ACS99535.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 ComR tetratricopeptide MarR PF01047.22 ACS99536.1 - 5.8e-18 64.6 0.0 8.2e-18 64.1 0.0 1.2 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACS99536.1 - 2.9e-14 52.7 0.0 4.1e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACS99536.1 - 1.9e-07 31.5 0.1 2.8e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.6 ACS99536.1 - 1.4e-06 27.7 0.0 2.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_34 PF13601.6 ACS99536.1 - 7.7e-06 26.0 0.1 1.4e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.19 ACS99536.1 - 0.00064 19.5 0.0 0.0021 17.9 0.0 1.7 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 ACS99536.1 - 0.0051 16.6 0.1 0.0074 16.1 0.1 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_Crp_2 PF13545.6 ACS99536.1 - 0.0052 16.7 0.1 0.022 14.8 0.1 1.9 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain Rol_Rep_N PF18106.1 ACS99536.1 - 0.018 15.3 0.0 0.038 14.3 0.0 1.6 2 0 0 2 2 2 0 Rolling Circle replication initiation protein N-terminal domain HTH_5 PF01022.20 ACS99536.1 - 0.02 14.8 0.1 0.044 13.7 0.1 1.7 1 1 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_Mga PF08280.11 ACS99536.1 - 0.03 14.4 0.3 0.062 13.3 0.1 1.7 2 0 0 2 2 1 0 M protein trans-acting positive regulator (MGA) HTH domain RQC PF09382.10 ACS99536.1 - 0.062 13.1 0.0 1.7 8.5 0.0 2.2 1 1 1 2 2 2 0 RQC domain PadR PF03551.14 ACS99536.1 - 0.065 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family Coat_F PF07875.12 ACS99536.1 - 0.073 13.3 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Coat F domain DUF615 PF04751.14 ACS99536.1 - 0.092 12.7 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF615) HxlR PF01638.17 ACS99536.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Cas9_a PF18470.1 ACS99536.1 - 0.11 12.1 0.1 8.6 5.8 0.1 2.1 1 1 1 2 2 2 0 Cas9 alpha-helical lobe domain HTH_47 PF16221.5 ACS99536.1 - 0.11 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 winged helix-turn-helix MFS_1 PF07690.16 ACS99537.1 - 1.6e-48 165.4 55.7 1.8e-48 165.3 52.1 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily LysM PF01476.20 ACS99538.1 - 8.1e-25 86.6 0.0 1.9e-13 50.2 0.0 2.5 2 0 0 2 2 2 2 LysM domain Glyco_hydro_18 PF00704.28 ACS99538.1 - 1e-21 78.0 0.0 1.3e-21 77.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 AIRC PF00731.20 ACS99539.1 - 1.1e-66 223.0 0.4 1.2e-66 222.8 0.4 1.0 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 ACS99540.1 - 1.1e-60 204.1 0.0 1.9e-60 203.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 ACS99540.1 - 7.3e-13 48.0 0.3 1.5e-12 47.0 0.3 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 ACS99540.1 - 1.2e-09 38.0 0.1 4.1e-09 36.3 0.1 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.17 ACS99540.1 - 2.6e-09 36.9 0.1 4.1e-09 36.2 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain 2-Hacid_dh_C PF02826.19 ACS99540.1 - 0.00011 21.7 0.0 0.00025 20.4 0.0 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ATP-grasp_5 PF13549.6 ACS99540.1 - 0.0044 16.5 0.1 0.013 15.0 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain NAD_binding_2 PF03446.15 ACS99540.1 - 0.0057 16.8 0.1 0.015 15.5 0.1 1.8 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase GARS_A PF01071.19 ACS99540.1 - 0.014 15.2 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 ACS99540.1 - 0.021 14.5 0.0 0.5 9.9 0.0 2.7 2 1 0 2 2 2 0 RimK-like ATP-grasp domain Lyase_1 PF00206.20 ACS99541.1 - 4.6e-74 249.6 0.0 6.2e-74 249.2 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 ACS99541.1 - 3.6e-23 81.9 0.0 8.9e-23 80.6 0.0 1.7 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus Baculo_p47 PF05112.12 ACS99541.1 - 0.079 12.5 0.0 0.18 11.4 0.0 1.5 2 0 0 2 2 2 0 Baculovirus P47 protein SAICAR_synt PF01259.18 ACS99542.1 - 7.7e-87 291.1 0.0 9e-87 290.8 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase PurS PF02700.14 ACS99543.1 - 6.2e-34 116.0 0.3 6.8e-34 115.9 0.3 1.0 1 0 0 1 1 1 1 Phosphoribosylformylglycinamidine (FGAM) synthase GATase_5 PF13507.6 ACS99544.1 - 4.7e-43 147.2 0.1 6.2e-43 146.8 0.1 1.1 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase_3 PF07685.14 ACS99544.1 - 2.8e-07 30.3 0.0 5.2e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 ACS99544.1 - 3.4e-07 30.2 0.0 5.2e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 ACS99544.1 - 5.5e-07 29.5 0.0 1.6e-06 28.1 0.0 1.8 1 1 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 ACS99544.1 - 0.012 15.5 0.0 0.029 14.2 0.0 1.6 2 0 0 2 2 2 0 SNO glutamine amidotransferase family Peptidase_C26 PF07722.13 ACS99544.1 - 0.092 12.5 0.1 0.21 11.3 0.1 1.8 1 1 0 1 1 1 0 Peptidase C26 AIRS_C PF02769.22 ACS99545.1 - 5.2e-58 195.6 7.4 1.6e-35 122.6 0.1 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.24 ACS99545.1 - 6.2e-53 177.4 1.3 4.4e-26 91.4 0.2 2.5 2 0 0 2 2 2 2 AIR synthase related protein, N-terminal domain FGAR-AT_linker PF18072.1 ACS99545.1 - 9.9e-15 54.8 0.0 2.2e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain UPF0126 PF03458.13 ACS99545.1 - 3.6 7.5 5.8 8.6 6.3 0.1 2.7 2 0 0 2 2 2 0 UPF0126 domain GATase_7 PF13537.6 ACS99546.1 - 2e-25 89.1 0.0 3.7e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ACS99546.1 - 1.7e-22 80.1 0.0 4.6e-22 78.7 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 ACS99546.1 - 2e-07 30.7 0.1 3.9e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 ACS99546.1 - 0.001 18.0 0.0 0.002 17.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II DUF3700 PF12481.8 ACS99546.1 - 0.1 12.1 0.0 0.25 10.8 0.0 1.5 1 1 0 1 1 1 0 Aluminium induced protein AIRS_C PF02769.22 ACS99547.1 - 1.1e-36 126.3 0.0 2.4e-36 125.2 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 ACS99547.1 - 5.2e-18 65.5 2.2 1e-17 64.5 0.4 2.3 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain Formyl_trans_N PF00551.19 ACS99548.1 - 2.1e-54 184.0 0.0 2.4e-54 183.8 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase AICARFT_IMPCHas PF01808.18 ACS99549.1 - 2.4e-122 408.0 0.9 3.1e-122 407.7 0.9 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 ACS99549.1 - 5.6e-26 90.6 0.0 1.9e-25 88.8 0.0 2.0 1 0 0 1 1 1 1 MGS-like domain GARS_A PF01071.19 ACS99550.1 - 2.2e-80 269.0 0.4 3.2e-80 268.5 0.4 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 ACS99550.1 - 2.3e-35 121.2 0.7 1.8e-34 118.4 0.1 2.4 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 ACS99550.1 - 2.3e-30 104.7 1.6 2.3e-30 104.7 1.6 1.9 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain CPSase_L_D2 PF02786.17 ACS99550.1 - 3.1e-07 30.1 0.2 6.7e-07 29.0 0.2 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.14 ACS99550.1 - 3.2e-06 27.3 0.0 5.7e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 ACS99550.1 - 1.4e-05 24.8 0.5 3.4e-05 23.5 0.1 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.6 ACS99550.1 - 3.9e-05 23.3 0.4 9.4e-05 22.1 0.4 1.7 1 1 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ACS99550.1 - 0.00022 20.8 0.0 0.00035 20.2 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_2 PF08442.10 ACS99550.1 - 0.00084 19.0 0.1 0.0016 18.1 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 ACS99550.1 - 0.018 14.6 0.0 0.049 13.2 0.0 1.7 1 0 0 1 1 1 0 RimK-like ATP-grasp domain LAL_C2 PF18603.1 ACS99550.1 - 2 8.6 5.3 3.2 8.0 1.6 2.6 2 0 0 2 2 2 0 L-amino acid ligase C-terminal domain 2 FixP_N PF14715.6 ACS99551.1 - 0.044 13.5 1.8 0.044 13.5 1.8 1.9 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP UPF0370 PF13980.6 ACS99551.1 - 0.07 13.2 1.8 0.083 12.9 1.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) Hydrolase_4 PF12146.8 ACS99552.1 - 2.4e-16 59.8 0.1 2e-15 56.7 0.2 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ACS99552.1 - 1.2e-13 51.3 0.6 4.5e-12 46.1 0.2 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACS99552.1 - 6.1e-12 46.6 1.2 1.5e-11 45.3 1.2 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ACS99552.1 - 2.4e-09 37.0 0.1 1.1e-08 34.9 0.1 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 ACS99552.1 - 3.7e-09 35.7 0.0 5.1e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) PGAP1 PF07819.13 ACS99552.1 - 1.3e-06 28.3 0.0 2.9e-06 27.2 0.0 1.6 2 0 0 2 2 2 1 PGAP1-like protein Esterase PF00756.20 ACS99552.1 - 7.7e-06 25.7 0.0 2.1e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Putative esterase DLH PF01738.18 ACS99552.1 - 1.2e-05 25.0 0.0 0.00037 20.1 0.0 2.7 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S15 PF02129.18 ACS99552.1 - 6.2e-05 22.7 0.1 0.0012 18.6 0.1 2.1 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 ACS99552.1 - 0.00012 22.0 0.0 0.23 11.2 0.0 3.0 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 ACS99552.1 - 0.00023 21.1 0.0 0.00037 20.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 ACS99552.1 - 0.00053 19.9 0.0 0.00079 19.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.7 ACS99552.1 - 0.0023 17.7 0.0 0.012 15.4 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family LIP PF03583.14 ACS99552.1 - 0.0025 17.2 0.1 0.28 10.5 0.1 2.1 2 0 0 2 2 2 1 Secretory lipase PAF-AH_p_II PF03403.13 ACS99552.1 - 0.0031 16.1 0.0 0.0067 15.0 0.0 1.5 2 0 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II BAAT_C PF08840.11 ACS99552.1 - 0.0099 15.8 0.0 0.024 14.6 0.0 1.7 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1057 PF06342.12 ACS99552.1 - 0.011 14.8 0.0 0.14 11.2 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) DUF2974 PF11187.8 ACS99552.1 - 0.024 14.2 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF1749 PF08538.10 ACS99552.1 - 0.052 12.6 0.0 0.075 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) DUF676 PF05057.14 ACS99552.1 - 0.055 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Thioesterase PF00975.20 ACS99552.1 - 0.074 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain HD_assoc PF13286.6 ACS99552.1 - 0.16 12.5 0.1 0.45 11.1 0.1 1.7 1 0 0 1 1 1 0 Phosphohydrolase-associated domain DUF3048 PF11258.8 ACS99553.1 - 5.4e-51 172.5 0.0 1.1e-50 171.6 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3048) N-terminal domain DUF3048_C PF17479.2 ACS99553.1 - 3.6e-26 91.7 0.0 5.7e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3048) C-terminal domain PhoU_div PF01865.16 ACS99554.1 - 1.8e-22 79.7 8.3 2.2e-22 79.5 8.3 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 CHASE9 PF17153.4 ACS99554.1 - 0.39 10.9 3.6 11 6.2 0.2 2.9 2 2 0 3 3 3 0 Periplasmic sensor domain, extracellular PHO4 PF01384.20 ACS99555.1 - 9.1e-90 301.1 35.9 3.3e-89 299.3 35.9 1.7 1 1 0 1 1 1 1 Phosphate transporter family MTES_1575 PF18741.1 ACS99557.1 - 1.3e-06 28.5 0.0 2.9e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 REase_MTES_1575 DUF559 PF04480.12 ACS99557.1 - 9e-06 25.5 0.0 1.6e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF559) HTH_28 PF13518.6 ACS99557.1 - 5.2e-05 23.3 0.4 8.9e-05 22.5 0.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_DeoR PF08220.12 ACS99557.1 - 0.0022 17.7 0.0 0.005 16.6 0.0 1.7 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain MarR PF01047.22 ACS99557.1 - 0.0053 16.7 0.1 0.01 15.8 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_23 PF13384.6 ACS99557.1 - 0.007 16.1 0.3 0.012 15.3 0.3 1.4 1 0 0 1 1 1 1 Homeodomain-like domain GntR PF00392.21 ACS99557.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family MarR_2 PF12802.7 ACS99557.1 - 0.021 14.7 0.1 0.045 13.6 0.1 1.5 1 0 0 1 1 1 0 MarR family FaeA PF04703.12 ACS99557.1 - 0.084 13.3 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 FaeA-like protein HTH_11 PF08279.12 ACS99557.1 - 0.13 12.2 0.0 0.62 10.1 0.0 2.0 1 1 1 2 2 2 0 HTH domain Trp_repressor PF01371.19 ACS99559.1 - 1.3e-33 115.0 0.0 1.4e-33 114.8 0.0 1.0 1 0 0 1 1 1 1 Trp repressor protein HTH_38 PF13936.6 ACS99559.1 - 0.0032 17.2 0.2 0.021 14.6 0.3 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 ACS99559.1 - 0.06 13.2 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain HTH_7 PF02796.15 ACS99559.1 - 0.069 13.2 0.2 0.17 11.9 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase GerE PF00196.19 ACS99559.1 - 0.12 11.9 0.1 0.19 11.3 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 ACS99559.1 - 0.15 12.2 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain CbiX PF01903.17 ACS99560.1 - 4.7e-26 91.2 0.0 1.4e-15 57.5 0.0 2.1 2 0 0 2 2 2 2 CbiX DAGK_cat PF00781.24 ACS99561.1 - 1.6e-36 124.7 0.0 2.5e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 ACS99561.1 - 0.00055 19.2 0.0 0.00078 18.7 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase tRNA_U5-meth_tr PF05958.11 ACS99562.1 - 1.8e-23 83.1 0.0 4.1e-22 78.6 0.0 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 ACS99562.1 - 5.1e-11 42.6 0.0 8e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TRAM PF01938.20 ACS99562.1 - 2.4e-10 40.2 0.2 6.3e-10 38.9 0.2 1.7 1 0 0 1 1 1 1 TRAM domain Met_10 PF02475.16 ACS99562.1 - 6.2e-08 32.6 0.1 1.3e-07 31.6 0.1 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.6 ACS99562.1 - 9.3e-07 29.5 0.0 2.8e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ACS99562.1 - 7.5e-05 22.3 0.0 0.00013 21.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_15 PF09445.10 ACS99562.1 - 7.6e-05 22.3 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 ACS99562.1 - 0.00027 20.5 0.0 0.00043 19.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ACS99562.1 - 0.00067 20.3 0.0 0.0026 18.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ACS99562.1 - 0.019 14.9 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ACS99562.1 - 0.019 14.7 0.0 0.046 13.5 0.0 1.6 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPMT PF05724.11 ACS99562.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) HATPase_c PF02518.26 ACS99563.1 - 1.6e-33 115.6 0.0 8.3e-20 71.4 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ACS99563.1 - 2.1e-26 92.3 0.0 3.9e-26 91.4 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain His_kinase PF06580.13 ACS99563.1 - 1.2e-19 70.4 0.0 2.8e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase 7TMR-DISM_7TM PF07695.11 ACS99563.1 - 1.3e-11 44.8 34.3 1.3e-11 44.8 34.3 2.8 4 0 0 4 4 4 1 7TM diverse intracellular signalling HisKA PF00512.25 ACS99563.1 - 5.1e-11 42.4 0.2 1.2e-10 41.3 0.2 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ACS99563.1 - 1.3e-06 28.3 0.1 0.068 13.0 0.0 2.4 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACS99563.1 - 2.9e-05 24.0 0.0 0.1 12.5 0.0 2.4 2 0 0 2 2 2 2 Histidine kinase-like ATPase domain DUF2518 PF10726.9 ACS99563.1 - 0.035 13.8 2.5 0.38 10.4 0.7 2.6 2 0 0 2 2 2 0 Protein of function (DUF2518) Response_reg PF00072.24 ACS99564.1 - 2.5e-22 79.2 0.3 5e-22 78.2 0.3 1.5 1 0 0 1 1 1 1 Response regulator receiver domain BTAD PF03704.17 ACS99564.1 - 7.7e-10 39.4 0.5 1.5e-09 38.4 0.5 1.5 1 0 0 1 1 1 1 Bacterial transcriptional activator domain Trans_reg_C PF00486.28 ACS99564.1 - 0.032 14.3 0.0 0.067 13.3 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal Big_2 PF02368.18 ACS99565.1 - 8.7e-67 221.0 312.8 1.5e-08 34.4 17.4 21.2 13 11 7 20 20 17 10 Bacterial Ig-like domain (group 2) SLH PF00395.20 ACS99565.1 - 2.1e-28 98.1 5.1 5e-12 45.6 0.1 3.9 3 0 0 3 3 3 3 S-layer homology domain fn3 PF00041.21 ACS99565.1 - 3.7e-15 56.0 4.7 3.3e-11 43.4 0.5 7.0 9 0 0 9 9 5 2 Fibronectin type III domain Big_3 PF07523.12 ACS99565.1 - 4e-14 52.7 106.2 0.084 13.2 1.8 15.4 12 5 4 16 16 15 10 Bacterial Ig-like domain (group 3) Flg_new PF09479.10 ACS99565.1 - 1.4e-12 47.6 3.6 1.4e-12 47.6 3.6 8.9 9 0 0 9 9 9 1 Listeria-Bacteroides repeat domain (List_Bact_rpt) Ntox50 PF15542.6 ACS99565.1 - 8.8e-10 39.3 57.5 2.6 8.9 0.4 10.9 10 0 0 10 10 10 9 Bacterial toxin 50 Ig_Tie2_1 PF10430.9 ACS99565.1 - 8.3e-09 35.8 43.6 2.2 8.8 0.1 10.8 10 0 0 10 10 10 5 Tie-2 Ig-like domain 1 NPCBM_assoc PF10633.9 ACS99565.1 - 2.4e-06 27.7 100.5 1.3 9.4 0.7 15.7 12 6 0 12 12 12 11 NPCBM-associated, NEW3 domain of alpha-galactosidase Cu-oxidase PF00394.22 ACS99565.1 - 2.8e-06 27.5 52.9 4.7 7.3 0.2 12.3 11 1 0 12 12 12 6 Multicopper oxidase DUF4959 PF16323.5 ACS99565.1 - 7.9e-05 22.9 0.4 0.0013 19.1 0.4 3.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4959) Baculo_p24 PF05073.12 ACS99565.1 - 0.00013 21.8 11.2 1e+02 2.6 0.0 9.1 10 0 0 10 10 10 0 Baculovirus P24 capsid protein DUF2525 PF10733.9 ACS99565.1 - 0.0028 17.9 27.3 26 5.2 0.1 10.1 10 0 0 10 10 10 0 Protein of unknown function (DUF2525) MG2 PF01835.19 ACS99565.1 - 4.6 7.8 55.6 37 4.9 0.4 12.1 12 0 0 12 12 12 0 MG2 domain GerA PF03323.13 ACS99566.1 - 2.5e-117 392.2 2.9 3.5e-117 391.8 2.9 1.2 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_permease PF03845.13 ACS99567.1 - 2.4e-17 62.8 31.5 2.4e-17 62.8 31.5 1.3 1 1 0 1 1 1 1 Spore germination protein Spore_GerAC PF05504.11 ACS99568.1 - 2.3e-22 80.0 0.1 3.4e-22 79.4 0.1 1.2 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal Urocanase PF01175.18 ACS99568.1 - 0.066 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Urocanase Rossmann-like domain Glyco_hydro_43 PF04616.14 ACS99569.1 - 2.5e-95 319.1 0.0 1.3e-93 313.5 0.0 2.4 2 1 0 2 2 2 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 ACS99569.1 - 8.1e-56 188.9 0.0 1.4e-55 188.2 0.0 1.4 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF1349 PF07081.11 ACS99569.1 - 0.0019 18.0 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) DUF5005 PF16396.5 ACS99569.1 - 0.04 12.6 1.0 0.12 11.1 0.4 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF5005) Glyco_hydro_32N PF00251.20 ACS99569.1 - 0.091 12.3 0.3 0.51 9.9 0.0 2.2 3 0 0 3 3 3 0 Glycosyl hydrolases family 32 N-terminal domain BPD_transp_1 PF00528.22 ACS99570.1 - 1.2e-19 70.8 11.7 1.2e-19 70.8 11.7 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99571.1 - 1.3e-18 67.3 9.2 1.3e-18 67.3 9.2 1.7 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_1 PF01547.25 ACS99572.1 - 2.9e-37 129.3 12.8 4.4e-37 128.7 12.8 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACS99572.1 - 0.0061 16.0 0.3 3.5 7.0 0.0 2.6 2 1 0 2 2 2 2 Bacterial extracellular solute-binding protein Gly_kinase PF02595.15 ACS99572.1 - 0.034 13.2 0.0 0.055 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycerate kinase family UVR PF02151.19 ACS99572.1 - 0.38 10.5 2.6 0.26 11.1 0.4 1.9 2 0 0 2 2 2 0 UvrB/uvrC motif Myco_arth_vir_N PF09610.10 ACS99572.1 - 0.63 10.2 2.1 1.5 8.9 2.1 1.6 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) LPAM_2 PF13627.6 ACS99572.1 - 3 7.8 4.9 4.8 7.2 4.9 1.3 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site His_kinase PF06580.13 ACS99573.1 - 4e-24 84.8 2.8 6.9e-24 84.0 1.1 2.2 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACS99573.1 - 4.5e-15 56.1 2.4 7.9e-15 55.3 2.4 1.4 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACS99573.1 - 1.9e-09 38.0 0.0 4.4e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACS99573.1 - 1.2e-08 35.2 0.0 2.5e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 ACS99573.1 - 0.014 15.2 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ArlS_N PF18719.1 ACS99573.1 - 0.072 13.3 0.1 1 9.6 0.0 2.7 3 1 0 3 3 3 0 ArlS sensor domain HATPase_c_2 PF13581.6 ACS99573.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Response_reg PF00072.24 ACS99574.1 - 5.3e-26 91.0 0.3 1.2e-25 89.9 0.3 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99574.1 - 1.1e-21 76.8 0.1 2.5e-21 75.7 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99574.1 - 5.6e-16 58.2 0.6 2.6e-10 40.1 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACS99574.1 - 6.7e-09 36.0 0.0 1.8e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 GGDEF-like domain EKAL PF17986.1 ACS99574.1 - 0.086 12.9 0.0 0.27 11.3 0.0 1.8 1 0 0 1 1 1 0 EMP3-KAHRP-like N-terminal domain Glyco_hydro_42 PF02449.15 ACS99575.1 - 3.1e-78 263.7 0.5 3.9e-78 263.4 0.5 1.1 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_42M PF08532.10 ACS99575.1 - 5.5e-34 117.5 0.0 1e-33 116.6 0.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase trimerisation domain Glyco_hydro_35 PF01301.19 ACS99575.1 - 1e-05 25.3 0.1 1.8e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Cellulase PF00150.18 ACS99575.1 - 4.7e-05 23.0 0.0 7.6e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42C PF08533.10 ACS99575.1 - 0.00075 19.2 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase C-terminal domain Glyco_hydro_2_C PF02836.17 ACS99575.1 - 0.019 14.1 0.0 0.041 13.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain FTCD_C PF04961.12 ACS99576.1 - 1.9e-57 194.0 0.6 2.3e-57 193.7 0.6 1.0 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase PMEI PF04043.15 ACS99576.1 - 0.1 12.9 0.8 0.16 12.3 0.3 1.6 1 1 1 2 2 2 0 Plant invertase/pectin methylesterase inhibitor THF_DHG_CYH_C PF02882.19 ACS99577.1 - 4.3e-50 169.1 0.5 5.7e-50 168.7 0.5 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 ACS99577.1 - 9.6e-33 112.9 0.0 1.5e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Shikimate_DH PF01488.20 ACS99577.1 - 0.03 14.4 0.1 0.18 11.9 0.0 2.3 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Hydrolase PF00702.26 ACS99577.1 - 0.24 11.7 0.2 0.24 11.7 0.2 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase PGA_cap PF09587.10 ACS99578.1 - 1.1e-73 247.9 0.1 1.3e-73 247.6 0.1 1.1 1 0 0 1 1 1 1 Bacterial capsule synthesis protein PGA_cap SPC22 PF04573.12 ACS99579.1 - 0.11 12.0 1.2 0.88 9.0 0.1 2.0 2 0 0 2 2 2 0 Signal peptidase subunit NusG_II PF07009.11 ACS99579.1 - 0.71 10.1 4.2 10 6.4 0.4 2.1 1 1 1 2 2 2 0 NusG domain II ABC_membrane PF00664.23 ACS99580.1 - 3.2e-41 141.8 16.2 4.5e-41 141.3 16.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACS99580.1 - 6.3e-33 114.2 0.1 9.9e-33 113.6 0.1 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACS99580.1 - 3e-05 23.6 0.3 0.00098 18.6 0.1 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACS99580.1 - 5.3e-05 23.5 0.2 0.00062 20.1 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACS99580.1 - 0.00017 22.0 0.2 0.0007 20.0 0.2 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ACS99580.1 - 0.0014 19.1 0.2 0.022 15.2 0.2 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 ACS99580.1 - 0.0022 17.9 0.7 0.19 11.5 0.2 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 ACS99580.1 - 0.0025 17.6 0.0 0.25 11.0 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein T2SSE PF00437.20 ACS99580.1 - 0.0029 16.7 0.0 0.0053 15.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 ACS99580.1 - 0.0055 16.6 0.1 0.019 14.9 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 ACS99580.1 - 0.0078 16.0 0.1 0.19 11.4 0.1 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 ACS99580.1 - 0.011 15.4 0.2 0.078 12.7 0.2 2.1 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 ACS99580.1 - 0.024 14.4 0.4 0.24 11.1 0.4 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_23 PF13476.6 ACS99580.1 - 0.026 15.0 0.0 0.053 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ACS99580.1 - 0.058 13.4 0.1 0.31 11.0 0.0 2.0 1 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ACS99580.1 - 0.061 13.1 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 ACS99580.1 - 0.067 13.2 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 ACS99580.1 - 0.069 12.4 0.1 0.3 10.4 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin SRP54 PF00448.22 ACS99580.1 - 0.078 12.6 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_18 PF13238.6 ACS99580.1 - 0.085 13.4 0.0 0.18 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ACS99580.1 - 0.094 13.0 0.1 0.92 9.8 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_7 PF12775.7 ACS99580.1 - 0.095 12.2 0.1 0.23 10.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF87 PF01935.17 ACS99580.1 - 0.11 12.5 0.2 0.4 10.7 0.0 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 ACS99580.1 - 0.14 12.2 0.9 0.52 10.4 0.1 2.4 3 0 0 3 3 2 0 50S ribosome-binding GTPase ABC_membrane PF00664.23 ACS99581.1 - 7.3e-48 163.6 11.6 9.6e-48 163.2 11.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACS99581.1 - 5.6e-34 117.6 0.0 1.5e-33 116.2 0.0 1.8 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 ACS99581.1 - 2.1e-08 33.9 0.0 5.3e-06 26.0 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 ACS99581.1 - 0.00041 19.5 0.0 0.00075 18.6 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 ACS99581.1 - 0.00057 19.8 0.0 0.0017 18.3 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ACS99581.1 - 0.00085 19.7 0.1 0.0041 17.5 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain DUF3584 PF12128.8 ACS99581.1 - 0.0011 16.6 0.0 0.0017 16.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Zeta_toxin PF06414.12 ACS99581.1 - 0.0012 18.2 0.1 0.035 13.4 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_29 PF13555.6 ACS99581.1 - 0.0042 16.8 0.0 0.01 15.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACS99581.1 - 0.012 16.2 0.2 0.027 15.0 0.2 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ACS99581.1 - 0.038 14.3 0.0 0.17 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ACS99581.1 - 0.039 13.7 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 ACS99581.1 - 0.054 13.2 0.7 0.39 10.5 0.7 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_24 PF13479.6 ACS99581.1 - 0.062 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ACS99581.1 - 0.068 12.5 0.1 0.33 10.3 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 ACS99581.1 - 0.079 13.0 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.22 ACS99581.1 - 0.1 11.8 0.0 0.25 10.5 0.0 1.7 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.19 ACS99581.1 - 0.11 12.1 0.1 0.29 10.7 0.0 1.8 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 ACS99581.1 - 0.11 12.5 0.2 0.32 11.1 0.1 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain DLIC PF05783.11 ACS99581.1 - 0.12 11.1 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) NACHT PF05729.12 ACS99581.1 - 0.17 11.8 0.2 0.64 9.9 0.0 2.0 2 0 0 2 2 2 0 NACHT domain VirB3 PF05101.13 ACS99581.1 - 0.56 10.5 4.0 1.7 8.9 4.0 1.8 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein DUF4111 PF13427.6 ACS99582.1 - 1.2e-30 105.7 0.0 1.7e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4111) Polbeta PF18765.1 ACS99582.1 - 7e-06 26.0 0.0 1.6e-05 24.9 0.0 1.6 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 ACS99582.1 - 2e-05 24.8 0.0 4.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Adenyl_cycl_N PF12633.7 ACS99582.1 - 0.00055 19.9 0.0 0.00078 19.4 0.0 1.2 1 0 0 1 1 1 1 Adenylate cyclase NT domain Glyco_hydro_43 PF04616.14 ACS99583.1 - 1.1e-18 67.6 5.3 2.4e-18 66.4 5.3 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 fn3_3 PF14686.6 ACS99583.1 - 0.0017 18.1 2.9 0.0017 18.1 2.9 3.0 4 0 0 4 4 4 1 Polysaccharide lyase family 4, domain II Y_Y_Y PF07495.13 ACS99583.1 - 0.0037 17.2 0.7 0.013 15.5 0.7 1.9 1 0 0 1 1 1 1 Y_Y_Y domain WD40_3 PF15911.5 ACS99583.1 - 0.048 13.7 0.2 0.2 11.7 0.0 2.2 2 0 0 2 2 2 0 WD domain, G-beta repeat EPTP PF03736.17 ACS99583.1 - 0.059 13.4 0.2 0.92 9.6 0.1 2.8 2 0 0 2 2 2 0 EPTP domain CarboxypepD_reg PF13620.6 ACS99583.1 - 0.64 10.3 6.8 5.6 7.3 0.1 3.4 3 0 0 3 3 3 0 Carboxypeptidase regulatory-like domain Response_reg PF00072.24 ACS99584.1 - 1.6e-26 92.7 0.0 3.2e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99584.1 - 2.4e-18 66.1 0.0 7.3e-18 64.6 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99584.1 - 2.5e-13 49.7 0.9 9.4e-06 25.6 0.0 2.9 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACS99584.1 - 1.5e-08 34.9 0.0 4.6e-08 33.3 0.0 2.0 1 1 0 1 1 1 1 GGDEF-like domain GFO_IDH_MocA PF01408.22 ACS99584.1 - 0.05 14.4 0.0 0.23 12.3 0.0 2.1 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Phe_tRNA-synt_N PF02912.18 ACS99584.1 - 0.07 13.1 3.6 0.16 11.9 3.6 1.6 1 0 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain His_kinase PF06580.13 ACS99585.1 - 6.1e-25 87.3 1.6 9.4e-25 86.7 0.3 2.1 2 0 0 2 2 2 1 Histidine kinase HAMP PF00672.25 ACS99585.1 - 6.4e-10 39.3 0.0 1.4e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACS99585.1 - 1.3e-09 38.5 0.0 2.9e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACS99585.1 - 4.3e-09 36.5 0.8 4.3e-09 36.5 0.8 1.9 2 0 0 2 2 2 1 Cache domain HATPase_c_2 PF13581.6 ACS99585.1 - 0.0023 17.9 0.0 0.0046 16.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain DUF3502 PF12010.8 ACS99586.1 - 1.8e-30 106.3 0.0 4.1e-30 105.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACS99586.1 - 4.9e-09 36.6 9.2 1.2e-08 35.4 5.4 2.3 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein DUF5010 PF16402.5 ACS99586.1 - 0.017 13.9 0.0 0.065 12.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5010) BPD_transp_1 PF00528.22 ACS99587.1 - 1.6e-16 60.6 11.2 1.6e-16 60.6 11.2 1.9 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99588.1 - 1e-11 44.9 25.5 9e-11 41.8 25.8 2.0 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF3502 PF12010.8 ACS99589.1 - 4.1e-30 105.1 0.2 1.1e-29 103.7 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) DUF3558 PF12079.8 ACS99589.1 - 1.2 9.1 5.7 2.4 8.1 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) His_Phos_1 PF00300.22 ACS99590.1 - 3.8e-29 101.8 0.0 4.7e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AI-2E_transport PF01594.16 ACS99591.1 - 7.8e-72 242.2 36.2 9.7e-72 241.9 36.2 1.1 1 0 0 1 1 1 1 AI-2E family transporter T2SSM PF04612.12 ACS99591.1 - 0.00084 19.4 0.0 0.0019 18.3 0.0 1.5 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein M Spore_permease PF03845.13 ACS99592.1 - 1.1e-47 162.4 32.3 1.8e-47 161.8 32.3 1.3 1 0 0 1 1 1 1 Spore germination protein zinc_ribbon_9 PF14369.6 ACS99592.1 - 0.081 13.2 0.3 0.15 12.4 0.3 1.3 1 0 0 1 1 1 0 zinc-ribbon GerA PF03323.13 ACS99593.1 - 5.9e-192 638.3 4.2 6.7e-192 638.1 4.2 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein UPF0180 PF03698.13 ACS99593.1 - 0.079 13.1 0.4 1.5 9.1 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) DUF1240 PF06836.12 ACS99593.1 - 4 8.0 7.6 0.23 12.0 1.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1240) Spore_permease PF03845.13 ACS99594.1 - 3.1e-43 147.8 33.9 4.1e-43 147.4 33.9 1.1 1 0 0 1 1 1 1 Spore germination protein Spore_GerAC PF05504.11 ACS99595.1 - 1e-33 116.9 0.3 1.5e-33 116.3 0.3 1.3 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal DUF3687 PF12459.8 ACS99596.1 - 4.9 6.8 8.7 1.2 8.7 4.8 2.0 2 0 0 2 2 2 0 D-Ala-teichoic acid biosynthesis protein LysM PF01476.20 ACS99597.1 - 5.7e-31 106.3 0.1 8.8e-10 38.5 0.0 3.4 3 0 0 3 3 3 3 LysM domain YkuD PF03734.14 ACS99597.1 - 1.6e-23 83.7 0.1 2.4e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 L,D-transpeptidase catalytic domain OapA PF04225.12 ACS99597.1 - 8.3e-05 22.6 0.0 0.25 11.5 0.0 2.7 2 0 0 2 2 2 2 Opacity-associated protein A LysM-like domain MFS_1 PF07690.16 ACS99598.1 - 3.4e-31 108.5 47.4 3.4e-31 108.5 47.4 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 ACS99598.1 - 0.022 13.0 14.3 0.35 9.1 0.8 2.6 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family HTH_18 PF12833.7 ACS99599.1 - 1.4e-20 73.4 1.6 2.2e-20 72.7 1.6 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99599.1 - 1.4e-15 56.9 0.7 1.4e-07 31.4 0.1 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACS99599.1 - 0.0001 21.9 0.4 0.00021 20.9 0.4 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACS99599.1 - 0.00072 19.5 0.4 0.0014 18.6 0.4 1.6 1 0 0 1 1 1 1 AraC-like ligand binding domain AraC_binding_2 PF14525.6 ACS99599.1 - 0.0011 18.6 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 AraC-binding-like domain Sigma70_r2 PF04542.14 ACS99599.1 - 0.13 12.0 0.3 0.39 10.5 0.1 1.9 2 0 0 2 2 2 0 Sigma-70 region 2 MerR_1 PF13411.6 ACS99600.1 - 8.4e-16 57.8 0.1 1.5e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACS99600.1 - 4e-15 55.3 5.6 7.7e-15 54.4 2.1 2.5 3 0 0 3 3 3 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACS99600.1 - 5.8e-06 26.7 0.1 1e-05 26.0 0.1 1.4 1 0 0 1 1 1 1 MerR, DNA binding HTH_23 PF13384.6 ACS99600.1 - 0.019 14.7 0.0 0.4 10.5 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain Spc24 PF08286.11 ACS99600.1 - 0.22 11.8 2.1 6.5 7.1 0.0 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Thioredoxin PF00085.20 ACS99601.1 - 4e-25 87.8 0.0 4.3e-25 87.7 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ACS99601.1 - 6.6e-07 29.7 0.0 1.1e-06 29.0 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ACS99601.1 - 1.7e-06 28.3 0.0 0.00039 20.7 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_9 PF14595.6 ACS99601.1 - 4.1e-05 23.3 0.0 4.7e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 ACS99601.1 - 7e-05 22.8 0.0 9.9e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain TraF PF13728.6 ACS99601.1 - 0.00021 21.2 0.0 0.00026 20.9 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Glutaredoxin PF00462.24 ACS99601.1 - 0.00081 19.6 0.0 0.0016 18.6 0.0 1.5 1 1 0 1 1 1 1 Glutaredoxin HyaE PF07449.11 ACS99601.1 - 0.00096 19.1 0.0 0.00098 19.1 0.0 1.1 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.6 ACS99601.1 - 0.0082 16.3 0.1 0.021 15.0 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 ACS99601.1 - 0.02 14.3 0.0 0.02 14.3 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 ACS99601.1 - 0.021 14.8 0.0 0.051 13.5 0.0 1.6 1 1 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 ACS99601.1 - 0.022 14.5 0.0 0.044 13.5 0.0 1.5 1 1 1 2 2 2 0 Redoxin DUF836 PF05768.14 ACS99601.1 - 0.043 14.2 0.0 0.048 14.1 0.0 1.2 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) KaiB PF07689.12 ACS99601.1 - 0.074 12.8 0.0 0.089 12.5 0.0 1.2 1 0 0 1 1 1 0 KaiB domain DIM1 PF02966.16 ACS99601.1 - 0.095 12.5 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 Thioredoxin_5 PF13743.6 ACS99601.1 - 0.1 12.3 0.1 0.54 9.9 0.0 1.8 1 1 1 2 2 2 0 Thioredoxin DUF953 PF06110.11 ACS99601.1 - 0.13 11.9 0.1 0.22 11.1 0.1 1.5 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Ank_4 PF13637.6 ACS99602.1 - 6.8e-31 106.3 7.6 1e-10 41.9 0.1 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ACS99602.1 - 2.4e-28 98.6 4.1 8.5e-12 45.5 0.9 3.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 ACS99602.1 - 4.4e-25 87.0 10.6 2.3e-06 27.8 0.1 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 ACS99602.1 - 1.1e-21 74.5 3.6 6e-06 26.2 0.0 5.1 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 ACS99602.1 - 1.9e-21 75.8 4.4 1.5e-08 34.7 0.1 3.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Tail_tube PF10618.9 ACS99602.1 - 0.028 14.3 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 Phage tail tube protein DUF3502 PF12010.8 ACS99603.1 - 1.1e-37 129.5 2.7 2.5e-37 128.4 2.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) DUF3558 PF12079.8 ACS99603.1 - 0.068 13.2 2.1 0.14 12.1 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) BEN PF10523.9 ACS99603.1 - 0.13 12.5 0.0 0.46 10.8 0.0 1.9 2 0 0 2 2 2 0 BEN domain BPD_transp_1 PF00528.22 ACS99604.1 - 1.4e-12 47.7 14.0 1.4e-12 47.7 14.0 2.6 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Sigma_reg_N PF13800.6 ACS99604.1 - 0.03 14.6 6.1 2.3 8.5 0.1 3.5 3 0 0 3 3 3 0 Sigma factor regulator N-terminal BPD_transp_1 PF00528.22 ACS99605.1 - 2e-13 50.5 13.7 2e-13 50.5 13.7 2.3 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component HTH_18 PF12833.7 ACS99606.1 - 9.4e-21 73.9 0.0 2.7e-20 72.4 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99606.1 - 4.9e-12 45.6 3.7 1.4e-07 31.4 0.1 3.1 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACS99606.1 - 2.6e-06 27.6 0.0 6.5e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 GGDEF-like domain Helicase_C_3 PF13625.6 ACS99606.1 - 0.0085 16.2 0.1 0.9 9.7 0.0 3.3 2 1 1 3 3 3 1 Helicase conserved C-terminal domain Beta_helix PF13229.6 ACS99607.1 - 1.8e-14 53.9 27.5 6.3e-10 39.1 5.7 3.2 1 1 0 2 2 2 2 Right handed beta helix region NosD PF05048.13 ACS99607.1 - 2e-10 40.3 16.0 1e-08 34.8 1.4 2.6 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.11 ACS99607.1 - 0.016 14.5 9.7 1.8 7.8 0.0 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF1565) FMN_red PF03358.15 ACS99608.1 - 1.3e-09 37.9 0.1 1.9e-08 34.2 0.1 2.1 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_5 PF12724.7 ACS99608.1 - 3.2e-06 27.5 0.0 4.1e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_1 PF00258.25 ACS99608.1 - 5.3e-06 26.7 0.0 9.9e-06 25.8 0.0 1.5 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_2 PF02525.17 ACS99608.1 - 5.5e-06 26.2 0.0 2.3e-05 24.2 0.0 1.9 1 1 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_3 PF12641.7 ACS99608.1 - 0.0017 18.1 0.0 0.0024 17.6 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin domain HisKA_4TM PF16926.5 ACS99608.1 - 0.033 13.8 0.5 0.19 11.3 0.1 2.0 2 0 0 2 2 2 0 Archaeal 4TM region of histidine kinase MFS_1 PF07690.16 ACS99609.1 - 1.5e-50 172.2 41.9 8.8e-49 166.3 42.1 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACS99609.1 - 3.5e-07 29.4 20.4 3e-06 26.4 10.5 3.2 3 2 1 4 4 4 2 Sugar (and other) transporter MarR PF01047.22 ACS99610.1 - 9.8e-17 60.6 1.1 2e-16 59.6 0.2 1.9 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.7 ACS99610.1 - 2.5e-13 49.7 0.4 4.4e-13 48.9 0.4 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACS99610.1 - 2.5e-11 43.9 1.5 4e-11 43.3 0.6 1.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_24 PF13412.6 ACS99610.1 - 1.2e-06 27.9 0.1 2.8e-06 26.8 0.1 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_34 PF13601.6 ACS99610.1 - 1.1e-05 25.5 0.1 2.3e-05 24.5 0.1 1.5 1 1 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.19 ACS99610.1 - 7.4e-05 22.6 0.1 0.00013 21.8 0.1 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Dimerisation2 PF16864.5 ACS99610.1 - 0.00015 21.7 0.1 0.00027 20.9 0.1 1.4 1 0 0 1 1 1 1 Dimerisation domain HTH_IclR PF09339.10 ACS99610.1 - 0.00023 20.9 0.2 0.0007 19.3 0.1 1.9 2 0 0 2 2 1 1 IclR helix-turn-helix domain Fe_dep_repress PF01325.19 ACS99610.1 - 0.002 18.3 0.1 0.0034 17.5 0.1 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HxlR PF01638.17 ACS99610.1 - 0.0025 17.6 0.5 0.0043 16.9 0.5 1.4 1 0 0 1 1 1 1 HxlR-like helix-turn-helix RPA_C PF08784.11 ACS99610.1 - 0.0031 18.1 0.5 0.39 11.4 0.1 2.1 2 0 0 2 2 2 1 Replication protein A C terminal Rrf2 PF02082.20 ACS99610.1 - 0.0065 16.8 0.2 0.012 15.9 0.2 1.4 1 0 0 1 1 1 1 Transcriptional regulator Penicillinase_R PF03965.16 ACS99610.1 - 0.007 16.7 0.4 0.023 15.1 0.4 1.9 1 1 0 1 1 1 1 Penicillinase repressor PaaX PF07848.12 ACS99610.1 - 0.015 15.5 0.1 0.024 14.8 0.1 1.4 1 0 0 1 1 1 0 PaaX-like protein CENP-B_N PF04218.13 ACS99610.1 - 0.017 14.7 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Dimerisation PF08100.11 ACS99610.1 - 0.024 14.7 0.2 0.047 13.7 0.2 1.5 1 0 0 1 1 1 0 Dimerisation domain HTH_20 PF12840.7 ACS99610.1 - 0.03 14.4 1.0 0.081 13.0 0.1 2.1 2 1 0 2 2 2 0 Helix-turn-helix domain TBD PF12845.7 ACS99610.1 - 0.066 13.1 1.6 0.82 9.6 0.5 2.4 2 0 0 2 2 2 0 TBD domain MCM6_C PF18263.1 ACS99610.1 - 0.078 13.2 1.1 0.11 12.7 0.4 1.6 1 1 0 1 1 1 0 MCM6 C-terminal winged-helix domain DUF945 PF06097.11 ACS99610.1 - 0.079 12.1 0.6 0.13 11.3 0.1 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF945) AbiEi_4 PF13338.6 ACS99610.1 - 0.092 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin FtsK_gamma PF09397.10 ACS99610.1 - 0.093 12.5 0.5 0.3 10.9 0.1 1.9 2 0 0 2 2 2 0 Ftsk gamma domain HTH_11 PF08279.12 ACS99610.1 - 0.1 12.6 0.8 0.28 11.1 0.0 2.0 2 0 0 2 2 2 0 HTH domain DUF2680 PF10925.8 ACS99610.1 - 0.12 12.4 0.8 6.8 6.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) tRNA-synt_His PF13393.6 ACS99611.1 - 1.2e-41 143.0 0.0 1.6e-41 142.6 0.0 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 ACS99611.1 - 3.7e-11 43.0 0.1 7.9e-11 42.0 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ACS99611.1 - 2.8e-05 24.2 0.0 6.3e-05 23.0 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 ACS99611.1 - 0.023 14.2 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Transketolase_C PF02780.20 ACS99611.1 - 0.089 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Transketolase, C-terminal domain tRNA-synt_2 PF00152.20 ACS99611.1 - 0.18 10.9 0.0 1.3 8.1 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) TehB PF03848.14 ACS99612.1 - 1.3e-22 80.2 0.0 1.6e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_25 PF13649.6 ACS99612.1 - 5.8e-19 68.6 0.0 9.8e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain HTH_3 PF01381.22 ACS99612.1 - 1.4e-15 57.0 0.0 2.8e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix Methyltransf_11 PF08241.12 ACS99612.1 - 5e-15 55.9 0.0 7.7e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACS99612.1 - 1.7e-14 54.3 0.0 2.7e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACS99612.1 - 5.4e-14 52.4 0.0 7.8e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACS99612.1 - 7.9e-14 51.7 0.0 1e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain HTH_19 PF12844.7 ACS99612.1 - 2.6e-10 40.2 0.0 8.7e-10 38.5 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain TPMT PF05724.11 ACS99612.1 - 8.1e-08 32.2 0.0 1.3e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) HTH_26 PF13443.6 ACS99612.1 - 8.9e-08 32.5 0.0 3.3e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 Cro/C1-type HTH DNA-binding domain CMAS PF02353.20 ACS99612.1 - 1.2e-07 31.3 0.0 1.8e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase HTH_31 PF13560.6 ACS99612.1 - 2.4e-07 31.0 0.0 5.7e-07 29.8 0.0 1.6 2 0 0 2 2 1 1 Helix-turn-helix domain MTS PF05175.14 ACS99612.1 - 2.6e-07 30.3 0.0 3.8e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain NodS PF05401.11 ACS99612.1 - 2.2e-06 27.4 0.0 3.1e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) DUF938 PF06080.12 ACS99612.1 - 0.00029 20.7 0.0 0.0031 17.3 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF938) YdaS_antitoxin PF15943.5 ACS99612.1 - 0.0018 18.1 0.0 0.014 15.2 0.0 2.2 2 0 0 2 2 2 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT CheR PF01739.18 ACS99612.1 - 0.0019 17.7 0.0 0.76 9.2 0.0 2.5 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_32 PF13679.6 ACS99612.1 - 0.0028 17.7 0.0 0.0046 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain HTH_23 PF13384.6 ACS99612.1 - 0.0054 16.5 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain P22_Cro PF14549.6 ACS99612.1 - 0.006 16.4 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 DNA-binding transcriptional regulator Cro Phage_CI_repr PF07022.13 ACS99612.1 - 0.0061 16.6 0.0 0.55 10.4 0.0 2.4 2 0 0 2 2 2 1 Bacteriophage CI repressor helix-turn-helix domain Sigma70_r4 PF04545.16 ACS99612.1 - 0.012 15.1 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 Methyltransf_8 PF05148.15 ACS99612.1 - 0.013 15.4 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase PCMT PF01135.19 ACS99612.1 - 0.015 15.1 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 ACS99612.1 - 0.016 14.8 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase MetW PF07021.12 ACS99612.1 - 0.027 14.1 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Mur_ligase PF01225.25 ACS99612.1 - 0.03 14.7 0.0 0.072 13.4 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, catalytic domain HTH_37 PF13744.6 ACS99612.1 - 0.039 13.9 0.1 0.11 12.4 0.0 1.8 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_28 PF13518.6 ACS99612.1 - 0.045 13.9 0.0 0.086 13.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Methyltransf_9 PF08003.11 ACS99612.1 - 0.082 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) HTH_11 PF08279.12 ACS99612.1 - 0.083 12.8 0.1 0.29 11.1 0.0 1.9 2 0 0 2 2 1 0 HTH domain MarR_2 PF12802.7 ACS99612.1 - 0.12 12.2 0.0 0.79 9.7 0.0 2.2 2 0 0 2 2 2 0 MarR family HTH_24 PF13412.6 ACS99612.1 - 0.17 11.5 0.0 0.41 10.3 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding adh_short_C2 PF13561.6 ACS99612.1 - 0.2 11.2 0.1 0.33 10.5 0.1 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Acetyltransf_1 PF00583.25 ACS99613.1 - 0.00018 21.7 0.0 0.00031 21.0 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family DUF1806 PF08830.10 ACS99614.1 - 2e-50 169.4 0.0 2.2e-50 169.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1806) PIG-L PF02585.17 ACS99615.1 - 7.9e-29 100.9 0.0 1.1e-28 100.4 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Transglut_core PF01841.19 ACS99616.1 - 4.3e-14 52.9 0.0 5.8e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF1801 PF08818.11 ACS99617.1 - 4.6e-17 62.3 0.0 5.5e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DU1801) Amidohydro_3 PF07969.11 ACS99618.1 - 6.9e-08 32.4 1.7 0.00014 21.5 0.0 3.3 2 1 1 4 4 4 2 Amidohydrolase family Amidohydro_1 PF01979.20 ACS99618.1 - 2.8e-07 30.2 0.0 5.2e-06 26.0 0.0 2.7 1 1 0 1 1 1 1 Amidohydrolase family SelA PF03841.13 ACS99619.1 - 5.5e-14 51.9 1.7 1.4e-12 47.3 1.7 2.7 1 1 0 1 1 1 1 L-seryl-tRNA selenium transferase Beta_elim_lyase PF01212.21 ACS99619.1 - 1.7e-06 27.5 0.1 2.7e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 ACS99619.1 - 1.6e-05 23.7 0.2 2.4e-05 23.0 0.2 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ACS99619.1 - 0.00013 21.5 1.9 0.0022 17.4 2.9 2.4 2 1 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family KDGP_aldolase PF07071.11 ACS99620.1 - 6.7e-99 330.1 1.4 7.8e-99 329.9 1.4 1.0 1 0 0 1 1 1 1 KDGP aldolase Aldolase PF01081.19 ACS99620.1 - 0.02 14.3 0.2 0.049 13.0 0.0 1.7 2 0 0 2 2 2 0 KDPG and KHG aldolase ETF_alpha PF00766.19 ACS99620.1 - 0.077 13.0 0.1 0.24 11.5 0.1 1.8 1 0 0 1 1 1 0 Electron transfer flavoprotein FAD-binding domain PfkB PF00294.24 ACS99621.1 - 1.8e-30 106.3 0.0 4.8e-30 104.9 0.0 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 ACS99621.1 - 0.046 13.1 0.0 0.071 12.5 0.0 1.2 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase UTRA PF07702.13 ACS99622.1 - 8.6e-18 64.5 0.0 1.2e-17 64.1 0.0 1.2 1 0 0 1 1 1 1 UTRA domain GntR PF00392.21 ACS99622.1 - 6.5e-15 54.5 0.1 1.1e-13 50.6 0.0 2.2 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_DeoR PF08220.12 ACS99622.1 - 0.014 15.1 0.0 0.34 10.7 0.0 2.4 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACS99622.1 - 0.015 15.2 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 HTH domain MarR_2 PF12802.7 ACS99622.1 - 0.017 15.0 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_36 PF13730.6 ACS99622.1 - 0.067 13.2 0.0 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_41 PF14502.6 ACS99622.1 - 0.072 12.8 0.1 2.5 7.8 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain RPA_C PF08784.11 ACS99622.1 - 0.14 12.8 0.1 0.78 10.4 0.1 2.3 1 1 1 2 2 2 0 Replication protein A C terminal DUF1801 PF08818.11 ACS99623.1 - 1.4e-14 54.3 0.0 2.7e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DU1801) Acetyltransf_3 PF13302.7 ACS99623.1 - 2.4e-10 41.2 0.0 3.9e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACS99623.1 - 2.6e-08 34.1 0.0 5.8e-08 33.0 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACS99623.1 - 4.7e-05 23.7 0.0 0.0001 22.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACS99623.1 - 0.00081 19.3 0.0 0.0023 17.9 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DinB_2 PF12867.7 ACS99624.1 - 3.4e-15 56.7 0.1 3.9e-15 56.5 0.1 1.0 1 0 0 1 1 1 1 DinB superfamily DinB PF05163.12 ACS99624.1 - 0.033 14.1 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 DinB family Response_reg PF00072.24 ACS99626.1 - 5e-25 87.8 0.1 1.5e-24 86.3 0.1 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99626.1 - 8.1e-17 61.3 0.0 3.2e-16 59.4 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99626.1 - 8.1e-15 54.5 0.0 1.5e-08 34.5 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DsrC PF04358.13 ACS99626.1 - 0.028 14.9 0.1 1.3 9.6 0.0 2.6 2 0 0 2 2 2 0 DsrC like protein DUF2710 PF10921.8 ACS99626.1 - 0.075 13.5 0.1 0.42 11.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2710) Gal4_dimer PF03902.13 ACS99626.1 - 0.15 12.3 0.0 0.48 10.6 0.0 1.9 1 0 0 1 1 1 0 Gal4-like dimerisation domain His_kinase PF06580.13 ACS99627.1 - 1.3e-21 76.7 2.1 3.1e-21 75.5 2.1 1.7 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACS99627.1 - 1.6e-09 38.0 0.0 3.2e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACS99627.1 - 3.5e-06 27.5 0.0 8.6e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4091 PF13320.6 ACS99627.1 - 0.029 14.5 0.5 43 4.3 0.3 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4091) HATPase_c_2 PF13581.6 ACS99627.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACS99627.1 - 0.12 12.1 0.0 0.32 10.8 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BPD_transp_1 PF00528.22 ACS99628.1 - 2.5e-08 33.9 15.9 2.5e-08 33.9 15.9 3.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99629.1 - 5.2e-11 42.6 21.5 3.7e-10 39.9 21.5 2.1 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component CBM_4_9 PF02018.17 ACS99630.1 - 3.7e-65 218.4 20.8 9.7e-18 64.8 4.9 6.1 7 0 0 7 7 7 5 Carbohydrate binding domain SLH PF00395.20 ACS99630.1 - 4.2e-35 119.5 0.8 2.6e-13 49.7 0.0 3.7 3 0 0 3 3 3 3 S-layer homology domain Glyco_hydro_16 PF00722.21 ACS99630.1 - 2e-27 95.8 1.4 4e-27 94.8 0.1 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 CBM_6 PF03422.15 ACS99630.1 - 1.5e-17 64.1 1.1 1.5e-17 64.1 1.1 4.2 4 0 0 4 4 4 1 Carbohydrate binding module (family 6) DUF5010_C PF18099.1 ACS99630.1 - 3.8e-09 36.7 0.4 8.1e-08 32.4 0.1 3.1 2 0 0 2 2 2 1 DUF5010 C-terminal domain DUF4627 PF15425.6 ACS99630.1 - 0.0001 22.0 18.1 0.55 9.8 0.4 6.5 6 2 0 6 6 6 2 Domain of unknown function (DUF4627) Big_5 PF13205.6 ACS99630.1 - 0.00091 19.9 0.1 0.16 12.7 0.0 3.8 2 0 0 2 2 2 1 Bacterial Ig-like domain Sec-ASP3 PF15432.6 ACS99630.1 - 0.0081 16.3 0.1 3.6 7.8 0.3 3.4 4 0 0 4 4 4 1 Accessory Sec secretory system ASP3 DUF642 PF04862.12 ACS99630.1 - 0.014 15.2 14.4 0.36 10.6 0.1 5.6 4 1 0 5 5 5 0 Protein of unknown function (DUF642) Invasin_D3 PF09134.10 ACS99630.1 - 0.042 14.2 3.8 0.33 11.3 0.0 4.4 4 0 0 4 4 4 0 Invasin, domain 3 Glyco_hydro_16 PF00722.21 ACS99631.1 - 1.6e-43 148.2 3.3 1.9e-43 148.0 3.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Laminin_G_3 PF13385.6 ACS99631.1 - 0.0015 18.7 1.3 0.0032 17.6 1.3 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily SBP_bac_1 PF01547.25 ACS99632.1 - 1.6e-15 57.9 17.3 3.7e-15 56.7 17.3 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein His_kinase PF06580.13 ACS99633.1 - 5.6e-25 87.5 0.7 5.6e-25 87.5 0.7 2.2 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACS99633.1 - 1.3e-21 77.5 3.5 1.3e-21 77.5 3.5 1.9 2 0 0 2 2 2 1 Cache domain HAMP PF00672.25 ACS99633.1 - 3.8e-14 52.8 0.1 9.7e-14 51.5 0.1 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACS99633.1 - 0.00024 21.6 0.2 0.00078 19.9 0.1 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PspB PF06667.12 ACS99633.1 - 0.011 15.8 1.2 1.3 9.1 0.0 2.6 2 0 0 2 2 2 0 Phage shock protein B Coagulase PF08764.10 ACS99633.1 - 0.057 13.6 0.7 0.1 12.8 0.2 1.6 2 0 0 2 2 2 0 Staphylococcus aureus coagulase RHD3 PF05879.12 ACS99633.1 - 0.12 10.4 1.1 0.18 9.9 1.1 1.2 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) CysA_C_terminal PF17850.1 ACS99633.1 - 0.15 12.7 0.1 24 5.6 0.0 2.5 2 0 0 2 2 2 0 CysA C-terminal regulatory domain Response_reg PF00072.24 ACS99634.1 - 6e-24 84.4 0.0 1.7e-23 82.9 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99634.1 - 1.6e-22 79.6 0.0 4.5e-22 78.1 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99634.1 - 1.1e-19 70.0 0.1 4e-10 39.5 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACS99634.1 - 5.5e-07 29.9 0.1 1.2e-06 28.7 0.1 1.6 1 0 0 1 1 1 1 GGDEF-like domain UPF0122 PF04297.14 ACS99634.1 - 2e-05 24.7 0.9 2e-05 24.7 0.9 2.1 2 0 0 2 2 2 1 Putative helix-turn-helix protein, YlxM / p13 like SBP_bac_8 PF13416.6 ACS99635.1 - 2.3e-41 142.5 7.5 2.3e-41 142.5 7.5 1.5 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACS99635.1 - 7.9e-36 124.6 10.9 7.9e-36 124.6 10.9 1.5 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein DUF5061 PF16587.5 ACS99635.1 - 0.0097 16.0 0.1 0.059 13.4 0.1 2.1 2 0 0 2 2 2 1 17 kDa common-antigen outer membrane protein BPD_transp_1 PF00528.22 ACS99636.1 - 2.1e-19 70.0 19.0 2.1e-19 70.0 19.0 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99637.1 - 3.6e-19 69.2 15.3 3.6e-19 69.2 15.3 2.5 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Sulfatase PF00884.23 ACS99638.1 - 3.3e-38 131.8 0.1 4.3e-38 131.4 0.1 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACS99638.1 - 1.6e-05 24.7 0.0 0.005 16.5 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 ACS99638.1 - 1.8e-05 23.6 0.1 2.7e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF4976 PF16347.5 ACS99638.1 - 0.0031 17.7 0.4 0.22 11.8 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4976) DUF1501 PF07394.12 ACS99638.1 - 0.014 14.5 0.2 0.028 13.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) FGE-sulfatase PF03781.16 ACS99639.1 - 1.5e-90 303.3 6.2 1.8e-90 303.1 6.2 1.0 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 SBP_bac_8 PF13416.6 ACS99640.1 - 5.6e-49 167.5 7.6 5.6e-49 167.5 7.6 1.7 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACS99640.1 - 1.9e-26 93.8 18.5 2.8e-26 93.2 18.5 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACS99641.1 - 4.2e-22 78.8 14.9 4.2e-22 78.8 14.9 3.0 2 2 1 3 3 3 1 Binding-protein-dependent transport system inner membrane component DUF1206 PF06724.11 ACS99641.1 - 0.031 14.3 5.9 1.3 9.2 0.1 3.4 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1206) DUF2628 PF10947.8 ACS99641.1 - 0.051 13.9 0.3 0.051 13.9 0.3 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2628) TM_PBP2_N PF16296.5 ACS99641.1 - 0.81 9.8 2.8 1.7 8.8 2.8 1.5 1 0 0 1 1 1 0 N-terminal of TM subunit in PBP-dependent ABC transporters Gemini_mov PF01708.16 ACS99641.1 - 1.2 8.9 0.0 1.2 8.9 0.0 2.9 3 0 0 3 3 3 0 Geminivirus putative movement protein HKR_ArcB_TM PF18415.1 ACS99641.1 - 1.5 9.7 16.7 0.37 11.6 0.3 3.7 3 0 0 3 3 3 0 Histidine kinase receptor ArcB trans-membrane domain BPD_transp_1 PF00528.22 ACS99642.1 - 5.1e-18 65.5 20.1 5.1e-18 65.5 20.1 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SLH PF00395.20 ACS99643.1 - 1.2e-36 124.4 8.5 1.1e-14 54.1 0.1 4.4 4 0 0 4 4 4 3 S-layer homology domain RicinB_lectin_2 PF14200.6 ACS99643.1 - 4e-26 91.6 60.3 4e-05 24.3 0.1 12.8 4 3 13 18 18 18 10 Ricin-type beta-trefoil lectin domain-like Pectate_lyase_3 PF12708.7 ACS99643.1 - 1.8e-14 54.1 1.2 1.8e-14 54.1 1.2 5.0 6 0 0 6 6 6 2 Pectate lyase superfamily protein Fascin PF06268.13 ACS99643.1 - 3e-10 40.3 0.2 2 8.7 0.1 8.0 8 0 0 8 8 8 1 Fascin domain Beta_helix PF13229.6 ACS99643.1 - 8.7e-10 38.7 26.9 2.8e-09 37.0 1.1 4.2 3 2 2 5 5 5 2 Right handed beta helix region CBM60 PF16841.5 ACS99643.1 - 0.0015 18.9 0.1 0.093 13.2 0.0 4.0 3 1 1 4 4 4 1 Ca-dependent carbohydrate-binding module xylan-binding CE2_N PF17996.1 ACS99643.1 - 0.072 13.1 0.0 0.83 9.7 0.0 2.6 2 0 0 2 2 2 0 Carbohydrate esterase 2 N-terminal MIR PF02815.19 ACS99643.1 - 0.13 12.1 0.1 18 5.1 0.0 3.6 3 0 0 3 3 3 0 MIR domain DUF3502 PF12010.8 ACS99644.1 - 4.3e-40 137.4 1.1 6.4e-40 136.8 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACS99644.1 - 1.7e-11 44.6 1.4 1.7e-11 44.6 1.4 2.1 2 1 0 2 2 2 1 Bacterial extracellular solute-binding protein His_kinase PF06580.13 ACS99645.1 - 1.4e-20 73.4 3.6 4.5e-20 71.7 3.6 1.9 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACS99645.1 - 2.7e-07 30.8 0.0 1.3e-06 28.7 0.0 2.1 2 0 0 2 2 2 1 HAMP domain HATPase_c PF02518.26 ACS99645.1 - 4.3e-07 30.4 0.0 1.3e-06 28.9 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACS99645.1 - 0.00038 20.3 7.1 0.0012 18.7 7.1 1.8 1 1 0 1 1 1 1 Cache domain DUF3727 PF12527.8 ACS99645.1 - 0.04 14.1 0.1 0.6 10.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3727) HTH_18 PF12833.7 ACS99646.1 - 7.8e-21 74.1 0.1 1.8e-20 72.9 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain Response_reg PF00072.24 ACS99646.1 - 2.2e-18 66.4 0.0 7.5e-18 64.7 0.0 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HTH_AraC PF00165.23 ACS99646.1 - 2.7e-13 49.7 0.0 4.2e-06 26.7 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GerA PF03323.13 ACS99647.1 - 4e-188 625.6 0.1 4.6e-188 625.4 0.1 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_permease PF03845.13 ACS99648.1 - 1.8e-60 204.5 23.5 2.5e-60 204.0 23.5 1.2 1 0 0 1 1 1 1 Spore germination protein DUF2456 PF10445.9 ACS99648.1 - 2.3 8.4 8.6 2.4 8.3 0.2 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF2456) Spore_GerAC PF05504.11 ACS99649.1 - 4e-33 115.0 0.0 7.4e-33 114.1 0.0 1.5 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal EamA PF00892.20 ACS99650.1 - 0.068 13.3 0.0 0.079 13.1 0.0 1.0 1 0 0 1 1 1 0 EamA-like transporter family CPBP PF02517.16 ACS99651.1 - 6.3e-19 68.1 6.3 6.3e-19 68.1 6.3 2.3 3 1 0 3 3 3 1 CPBP intramembrane metalloprotease Phage_holin_3_6 PF07332.11 ACS99651.1 - 5 7.2 10.1 1.8 8.7 0.6 3.3 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Peripla_BP_4 PF13407.6 ACS99652.1 - 4.9e-44 150.8 1.6 5.8e-44 150.6 1.6 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACS99652.1 - 1e-13 51.3 0.1 1.4e-13 50.9 0.1 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_6 PF13458.6 ACS99652.1 - 0.0025 17.6 0.6 0.035 13.8 0.1 2.3 1 1 1 2 2 2 2 Periplasmic binding protein THF_DHG_CYH PF00763.23 ACS99652.1 - 0.031 14.5 0.1 3.8 7.8 0.0 2.4 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Peripla_BP_3 PF13377.6 ACS99652.1 - 0.13 12.6 0.0 0.39 11.0 0.0 1.7 2 0 0 2 2 2 0 Periplasmic binding protein-like domain DUF3898 PF13037.6 ACS99652.1 - 0.16 12.1 0.5 0.86 9.7 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3898) His_kinase PF06580.13 ACS99653.1 - 5.9e-22 77.8 0.8 5.9e-22 77.8 0.8 3.1 3 0 0 3 3 3 1 Histidine kinase HAMP PF00672.25 ACS99653.1 - 3.3e-15 56.2 0.0 7.7e-15 55.0 0.0 1.7 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACS99653.1 - 4.4e-13 49.7 0.5 8.9e-13 48.7 0.5 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3974 PF13120.6 ACS99653.1 - 0.0039 17.3 1.5 0.56 10.3 0.1 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3974) HATPase_c_2 PF13581.6 ACS99653.1 - 0.021 14.8 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 ACS99653.1 - 0.026 14.4 0.4 0.11 12.4 0.1 2.2 2 0 0 2 2 2 0 GHKL domain HATPase_c_3 PF13589.6 ACS99653.1 - 0.027 14.3 0.1 0.059 13.2 0.1 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4389 PF14333.6 ACS99653.1 - 0.094 12.6 2.1 11 6.0 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4389) DUF4381 PF14316.6 ACS99653.1 - 0.21 11.8 0.7 9.3 6.5 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) PspB PF06667.12 ACS99653.1 - 0.25 11.4 2.4 0.48 10.5 0.3 2.6 2 0 0 2 2 2 0 Phage shock protein B 4HB_MCP_1 PF12729.7 ACS99653.1 - 0.37 10.3 12.3 0.12 11.9 6.5 2.7 2 1 0 2 2 2 0 Four helix bundle sensory module for signal transduction Sigma_reg_N PF13800.6 ACS99653.1 - 2.7 8.3 6.1 0.43 10.9 0.9 2.2 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF4199 PF13858.6 ACS99653.1 - 7.1 7.0 9.9 0.4 11.1 0.3 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF4199) Response_reg PF00072.24 ACS99654.1 - 5e-28 97.5 0.4 1.2e-27 96.3 0.4 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99654.1 - 2.2e-18 66.3 0.0 5.1e-18 65.1 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99654.1 - 2.1e-12 46.8 0.0 2.9e-07 30.4 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACS99654.1 - 3.4e-11 43.4 0.1 1.3e-10 41.5 0.0 2.0 2 0 0 2 2 2 1 GGDEF-like domain Ribosomal_S7 PF00177.21 ACS99654.1 - 0.079 12.6 0.2 1.8 8.2 0.1 2.5 2 0 0 2 2 2 0 Ribosomal protein S7p/S5e Peripla_BP_4 PF13407.6 ACS99655.1 - 2.8e-63 213.9 13.6 3.6e-63 213.6 13.6 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACS99655.1 - 1.7e-09 37.6 7.0 2.7e-08 33.6 6.9 2.1 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 ACS99655.1 - 9.6e-08 32.5 5.1 2.1e-06 28.2 0.4 2.5 1 1 1 2 2 2 2 Periplasmic binding protein-like domain AIRS_C PF02769.22 ACS99655.1 - 0.0078 16.4 0.5 4.3 7.4 0.1 2.6 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain IlvN PF07991.12 ACS99655.1 - 0.023 14.3 0.4 0.052 13.1 0.4 1.6 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Peripla_BP_4 PF13407.6 ACS99656.1 - 1.1e-59 202.1 16.1 1.7e-59 201.5 16.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein domain NAD_kinase PF01513.21 ACS99656.1 - 0.022 14.0 0.7 0.76 8.9 0.1 2.5 3 0 0 3 3 3 0 ATP-NAD kinase DUF3708 PF12501.8 ACS99656.1 - 0.07 12.9 0.2 0.18 11.6 0.2 1.7 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter Hpr_kinase_N PF02603.16 ACS99656.1 - 0.17 11.9 0.0 0.38 10.8 0.0 1.5 1 0 0 1 1 1 0 HPr Serine kinase N terminus LPAM_2 PF13627.6 ACS99656.1 - 7.9 6.5 6.2 20 5.2 6.2 1.7 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site ABC_tran PF00005.27 ACS99657.1 - 4.6e-50 169.7 0.9 4.7e-29 101.7 0.0 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACS99657.1 - 1.5e-10 41.4 0.6 0.0004 20.3 0.1 3.5 2 2 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS99657.1 - 5.8e-05 22.6 1.4 5.8e-05 22.6 1.4 2.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACS99657.1 - 8e-05 22.9 0.5 0.81 10.0 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 ACS99657.1 - 0.00051 19.7 1.3 0.0032 17.2 0.1 2.7 2 1 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ACS99657.1 - 0.00077 19.2 0.7 0.59 9.8 0.0 3.0 4 0 0 4 4 3 1 AAA domain AAA_23 PF13476.6 ACS99657.1 - 0.0013 19.3 1.2 0.008 16.7 1.4 2.2 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 ACS99657.1 - 0.0014 18.7 0.0 3 7.9 0.0 3.2 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 ACS99657.1 - 0.0014 18.6 1.8 0.0056 16.6 0.0 2.6 3 1 0 3 3 2 1 RsgA GTPase AAA_18 PF13238.6 ACS99657.1 - 0.0031 18.0 0.5 5.1 7.7 0.0 3.2 3 1 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 ACS99657.1 - 0.0034 17.2 1.6 4.2 7.1 0.1 3.6 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_15 PF13175.6 ACS99657.1 - 0.0055 16.5 0.3 0.0055 16.5 0.3 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA PF00004.29 ACS99657.1 - 0.0088 16.5 1.3 23 5.4 0.2 3.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_27 PF13514.6 ACS99657.1 - 0.027 14.0 0.0 0.064 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 ACS99657.1 - 0.031 13.4 0.4 0.24 10.5 0.0 2.3 3 0 0 3 3 3 0 MCM P-loop domain SbcCD_C PF13558.6 ACS99657.1 - 0.047 13.9 0.1 2.9 8.2 0.0 3.0 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit CobA_CobO_BtuR PF02572.15 ACS99657.1 - 0.053 13.8 0.2 0.13 12.5 0.2 1.7 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP AAA_16 PF13191.6 ACS99657.1 - 0.063 13.7 0.5 12 6.3 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain ABC_ATPase PF09818.9 ACS99657.1 - 0.064 12.0 7.3 3 6.5 0.2 3.7 3 1 0 3 3 3 0 Predicted ATPase of the ABC class AAA_25 PF13481.6 ACS99657.1 - 0.069 12.7 0.4 8.5 5.9 0.0 2.5 3 0 0 3 3 2 0 AAA domain DEAD PF00270.29 ACS99657.1 - 0.083 12.7 0.1 1.6 8.5 0.1 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase NACHT PF05729.12 ACS99657.1 - 0.093 12.7 0.4 1 9.2 0.0 2.5 3 0 0 3 3 3 0 NACHT domain DUF2813 PF11398.8 ACS99657.1 - 0.12 11.6 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) AAA_5 PF07728.14 ACS99657.1 - 0.13 12.2 0.7 1.9 8.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ACS99657.1 - 0.14 12.3 0.1 4.9 7.3 0.0 2.8 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ACS99657.1 - 0.21 11.7 1.4 1.4 9.0 0.0 2.7 3 1 0 3 3 3 0 50S ribosome-binding GTPase BPD_transp_2 PF02653.16 ACS99658.1 - 3.4e-37 128.1 52.9 2.6e-35 121.9 52.9 2.1 1 1 0 1 1 1 1 Branched-chain amino acid transport system / permease component Mycobact_memb PF05423.13 ACS99658.1 - 0.096 12.6 0.2 0.21 11.5 0.2 1.6 1 0 0 1 1 1 0 Mycobacterium membrane protein Xan_ur_permease PF00860.20 ACS99659.1 - 6.8e-102 341.1 40.8 6.8e-102 341.1 40.8 1.4 1 1 0 1 1 1 1 Permease family Dpy19 PF10034.9 ACS99659.1 - 0.37 8.9 1.3 0.7 8.0 1.3 1.4 1 0 0 1 1 1 0 Q-cell neuroblast polarisation SLH PF00395.20 ACS99660.1 - 2.5e-29 101.0 9.9 9.3e-14 51.2 0.4 4.2 4 0 0 4 4 4 3 S-layer homology domain Big_2 PF02368.18 ACS99660.1 - 3.8e-13 49.1 13.0 3.8e-13 49.1 13.0 6.0 6 0 0 6 6 6 2 Bacterial Ig-like domain (group 2) LTD PF00932.19 ACS99660.1 - 2e-12 47.5 0.3 2e-12 47.5 0.3 4.7 4 0 0 4 4 4 1 Lamin Tail Domain He_PIG PF05345.12 ACS99660.1 - 1.9e-08 34.3 9.1 1.9e-08 34.3 9.1 4.7 4 0 0 4 4 4 1 Putative Ig domain NO_synthase PF02898.15 ACS99660.1 - 0.0067 15.5 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain Nucleoporin2 PF04096.14 ACS99660.1 - 0.065 13.3 0.1 0.16 12.1 0.1 1.7 1 0 0 1 1 1 0 Nucleoporin autopeptidase YpsA PF06908.11 ACS99661.1 - 1e-62 211.1 0.7 1.2e-62 210.8 0.7 1.1 1 0 0 1 1 1 1 YspA SLOG family GFO_IDH_MocA PF01408.22 ACS99662.1 - 9.6e-30 103.9 0.2 1.5e-29 103.3 0.2 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 ACS99662.1 - 0.00023 21.6 0.0 0.00044 20.7 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 ACS99662.1 - 0.0024 18.5 0.1 0.004 17.8 0.1 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ACS99662.1 - 0.042 14.4 0.1 0.13 12.8 0.0 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA_C PF02894.17 ACS99662.1 - 0.18 11.8 0.0 0.55 10.3 0.0 1.9 1 1 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain SEC-C PF02810.15 ACS99663.1 - 6e-09 35.7 8.8 1.1e-08 34.9 8.8 1.4 1 0 0 1 1 1 1 SEC-C motif HTH_psq PF05225.16 ACS99663.1 - 0.00054 19.6 0.0 0.00092 18.9 0.0 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Ydc2-catalyt PF09159.10 ACS99663.1 - 0.0057 16.4 0.2 0.01 15.6 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 CENP-B_N PF04218.13 ACS99663.1 - 0.032 13.9 0.1 0.079 12.6 0.0 1.7 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain Trp_repressor PF01371.19 ACS99663.1 - 0.034 14.3 0.0 0.071 13.2 0.0 1.5 1 0 0 1 1 1 0 Trp repressor protein EF-hand_like PF09279.11 ACS99663.1 - 0.089 13.3 0.6 1.7 9.2 0.1 2.3 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like HTH_11 PF08279.12 ACS99663.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 HTH domain GntR PF00392.21 ACS99663.1 - 0.17 11.5 0.0 0.39 10.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Peptidase_M29 PF02073.15 ACS99664.1 - 2.5e-175 583.1 3.3 2.8e-175 583.0 3.3 1.0 1 0 0 1 1 1 1 Thermophilic metalloprotease (M29) MttA_Hcf106 PF02416.16 ACS99664.1 - 0.091 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 mttA/Hcf106 family DUF3886 PF13025.6 ACS99665.1 - 1.9e-23 82.4 17.2 2.8e-23 81.9 17.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3886) FPN1 PF06963.12 ACS99665.1 - 0.33 9.5 1.7 0.37 9.3 1.7 1.0 1 0 0 1 1 1 0 Ferroportin1 (FPN1) DUF1676 PF07898.13 ACS99665.1 - 0.8 9.7 5.6 0.92 9.5 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) Zip PF02535.22 ACS99665.1 - 5 6.3 4.4 5.2 6.2 4.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter ATP-synt_B PF00430.18 ACS99665.1 - 5.9 7.0 14.3 2.5 8.2 12.5 1.4 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) DUF1682 PF07946.14 ACS99665.1 - 7 5.8 13.1 7.6 5.6 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RNaseH_like PF04308.12 ACS99666.1 - 1.9e-48 164.1 0.0 2.3e-48 163.8 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease H-like Metallophos PF00149.28 ACS99667.1 - 5e-14 53.3 0.7 7.8e-14 52.7 0.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACS99667.1 - 9.1e-10 39.0 0.0 1.8e-09 38.0 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 ACS99667.1 - 0.013 14.8 0.0 0.047 13.0 0.0 2.0 1 1 1 2 2 2 0 Metallophosphoesterase, calcineurin superfamily FBPase_2 PF06874.11 ACS99667.1 - 0.021 13.1 0.3 1.6 6.9 0.0 2.5 3 0 0 3 3 3 0 Firmicute fructose-1,6-bisphosphatase HATPase_c PF02518.26 ACS99668.1 - 6.6e-19 68.5 0.5 1.6e-18 67.2 0.5 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACS99668.1 - 5.2e-12 45.6 0.1 1e-11 44.7 0.1 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ACS99668.1 - 8.1e-07 29.0 0.1 1.8e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 7TMR-DISM_7TM PF07695.11 ACS99668.1 - 6.3e-05 23.0 36.4 6.3e-05 23.0 36.4 1.8 2 0 0 2 2 2 1 7TM diverse intracellular signalling HATPase_c_2 PF13581.6 ACS99668.1 - 0.0071 16.3 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain SPOB_a PF14689.6 ACS99668.1 - 0.025 14.3 0.2 3.5 7.4 0.0 2.8 3 0 0 3 3 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain GED PF02212.18 ACS99668.1 - 0.11 12.7 0.6 0.25 11.5 0.2 1.9 2 0 0 2 2 2 0 Dynamin GTPase effector domain Pox_A14 PF05767.12 ACS99668.1 - 8.8 6.6 22.0 0.25 11.5 2.9 3.5 2 1 1 3 3 3 0 Poxvirus virion envelope protein A14 NHase_alpha PF02979.16 ACS99669.1 - 8.4e-11 41.5 0.4 3.9e-05 23.1 0.0 2.0 1 1 1 2 2 2 2 Nitrile hydratase, alpha chain Frankia_peptide PF14407.6 ACS99669.1 - 1.9e-05 24.5 0.1 2.6e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. DUF1844 PF08899.11 ACS99671.1 - 0.059 13.7 0.5 0.14 12.5 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1844) Peptidase_C92 PF05708.12 ACS99672.1 - 0.00026 21.2 0.1 0.0014 18.7 0.1 2.0 1 1 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family adh_short_C2 PF13561.6 ACS99673.1 - 4e-62 209.8 0.0 5.1e-62 209.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACS99673.1 - 9.8e-51 172.0 0.1 1.2e-50 171.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACS99673.1 - 4.7e-11 42.9 0.1 6.9e-11 42.4 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACS99673.1 - 0.0032 17.0 1.5 0.0067 15.9 0.1 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ACS99673.1 - 0.0069 15.6 0.2 0.0091 15.2 0.2 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 2-Hacid_dh_C PF02826.19 ACS99673.1 - 0.013 14.9 0.1 2.9 7.2 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 ACS99673.1 - 0.053 12.7 0.0 0.081 12.1 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein DUF1776 PF08643.10 ACS99673.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Peptidase_M75 PF09375.10 ACS99674.1 - 3.9e-38 131.6 6.8 5.1e-38 131.2 6.8 1.2 1 0 0 1 1 1 1 Imelysin DUF1843 PF08898.10 ACS99674.1 - 0.034 14.6 1.3 5.5 7.6 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) SLT PF01464.20 ACS99674.1 - 0.07 12.8 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 Transglycosylase SLT domain PSII_Pbs31 PF18240.1 ACS99674.1 - 0.26 11.8 0.1 0.26 11.8 0.1 2.8 2 1 1 3 3 3 0 Photosystem II Psb31 protein Dyp_perox PF04261.12 ACS99675.1 - 2.4e-105 352.2 0.0 2.8e-105 351.9 0.0 1.0 1 0 0 1 1 1 1 Dyp-type peroxidase family TAT_signal PF10518.9 ACS99675.1 - 0.0022 17.8 2.4 0.0022 17.8 2.4 2.0 2 0 0 2 2 2 1 TAT (twin-arginine translocation) pathway signal sequence FTR1 PF03239.14 ACS99676.1 - 8.4e-36 123.7 31.9 1.1e-19 70.8 12.3 2.1 2 1 1 3 3 3 2 Iron permease FTR1 family DUF4363 PF14276.6 ACS99676.1 - 0.00019 21.5 7.6 1.1 9.5 0.4 4.0 3 1 0 3 3 3 3 Domain of unknown function (DUF4363) GldM_N PF12081.8 ACS99676.1 - 0.017 15.3 0.1 0.017 15.3 0.1 2.3 2 0 0 2 2 2 0 GldM N-terminal domain DUF4293 PF14126.6 ACS99676.1 - 3.5 7.8 6.7 6.9 6.9 0.5 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4293) DUF2244 PF10003.9 ACS99676.1 - 9.2 5.9 11.0 0.27 10.9 2.2 2.9 3 1 0 3 3 3 0 Integral membrane protein (DUF2244) Glyco_hydro_26 PF02156.15 ACS99678.1 - 7.4e-10 38.7 1.7 1.1e-09 38.1 1.1 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 26 Lipase_3 PF01764.25 ACS99679.1 - 0.00015 21.7 0.0 0.00021 21.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ACS99679.1 - 0.015 14.9 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ACS99679.1 - 0.045 14.3 0.0 0.049 14.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 ACS99679.1 - 0.056 13.5 0.0 0.09 12.9 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Hydrolase_4 PF12146.8 ACS99679.1 - 0.085 12.1 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Lipase_3 PF01764.25 ACS99680.1 - 2.4e-33 115.0 0.0 3.5e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ACS99680.1 - 2.9e-05 23.7 0.0 4.3e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ACS99680.1 - 8.6e-05 23.2 0.0 9.5e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACS99680.1 - 0.0011 18.3 0.0 0.0015 17.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF676 PF05057.14 ACS99680.1 - 0.018 14.6 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Thioesterase PF00975.20 ACS99680.1 - 0.031 14.4 0.0 0.046 13.8 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_1 PF00561.20 ACS99680.1 - 0.047 13.3 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 ACS99680.1 - 0.064 13.0 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 ACS99680.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family tRNA-synt_2b PF00587.25 ACS99681.1 - 1.3e-39 136.1 0.0 3.1e-39 134.8 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ACS99681.1 - 1.5e-19 69.9 1.9 3.6e-19 68.7 1.2 2.0 2 0 0 2 2 2 1 Anticodon binding domain tRNA_SAD PF07973.14 ACS99681.1 - 5e-18 64.9 0.0 9.9e-18 64.0 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 ACS99681.1 - 0.049 13.7 0.0 0.23 11.5 0.0 2.3 2 0 0 2 2 2 0 TGS domain ThiS PF02597.20 ACS99681.1 - 0.14 12.8 0.0 0.76 10.5 0.0 2.2 2 0 0 2 2 2 0 ThiS family CorA PF01544.18 ACS99682.1 - 3.7e-32 111.8 0.7 3.7e-32 111.8 0.7 1.4 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein YflT PF11181.8 ACS99683.1 - 1.3e-11 44.9 1.2 2.7e-10 40.7 1.2 2.2 1 1 0 1 1 1 1 Heat induced stress protein YflT DUF501 PF04417.12 ACS99683.1 - 0.034 13.9 0.1 0.057 13.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF501) DAO PF01266.24 ACS99684.1 - 7.5e-50 170.5 0.0 8.5e-50 170.3 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ACS99684.1 - 4.2e-08 33.3 0.4 1.9e-07 31.2 0.3 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ACS99684.1 - 1.1e-07 31.5 0.1 0.003 16.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ACS99684.1 - 5.1e-05 22.1 1.4 0.0056 15.4 0.7 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_3 PF01494.19 ACS99684.1 - 0.00064 19.1 0.8 0.0012 18.2 0.2 1.7 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 ACS99684.1 - 0.00072 18.9 0.5 0.0014 17.9 0.5 1.4 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 ACS99684.1 - 0.0016 17.9 0.9 0.0031 16.9 0.8 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ACS99684.1 - 0.0016 17.6 1.7 0.0026 16.9 1.7 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 ACS99684.1 - 0.0062 15.8 2.6 1.7 7.8 1.5 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ACS99684.1 - 0.024 14.6 1.5 3 7.8 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding GIDA PF01134.22 ACS99684.1 - 0.024 13.7 1.2 0.041 13.0 0.8 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox PF00070.27 ACS99684.1 - 0.076 13.6 0.9 0.18 12.4 0.9 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HTH_AraC PF00165.23 ACS99685.1 - 8.9e-24 83.0 2.1 8.2e-11 41.7 0.1 3.0 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACS99685.1 - 7.3e-23 80.7 1.3 1.3e-22 79.8 0.4 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain AraC_binding PF02311.19 ACS99685.1 - 1.5e-19 70.2 0.0 2.9e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99685.1 - 8.2e-06 25.5 0.0 1.9e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 Cupin domain AraC_binding_2 PF14525.6 ACS99685.1 - 0.00028 20.6 0.0 0.00053 19.7 0.0 1.4 1 0 0 1 1 1 1 AraC-binding-like domain HTH_31 PF13560.6 ACS99685.1 - 0.00051 20.3 0.4 0.92 9.9 0.0 3.3 3 0 0 3 3 3 1 Helix-turn-helix domain Rrf2 PF02082.20 ACS99685.1 - 0.0021 18.4 0.0 0.047 14.0 0.0 2.3 2 0 0 2 2 2 1 Transcriptional regulator HTH_3 PF01381.22 ACS99685.1 - 0.0083 16.2 0.8 4.4 7.4 0.1 3.1 3 0 0 3 3 3 1 Helix-turn-helix ATP-synt PF00231.19 ACS99685.1 - 0.014 15.1 0.4 0.039 13.7 0.3 1.6 1 1 1 2 2 2 0 ATP synthase HTH_Crp_2 PF13545.6 ACS99685.1 - 0.027 14.4 0.0 0.54 10.3 0.0 2.3 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain Cupin_3 PF05899.12 ACS99685.1 - 0.037 13.7 0.0 0.071 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF861) HTH_23 PF13384.6 ACS99685.1 - 0.047 13.5 1.2 5.5 6.9 0.0 2.9 3 0 0 3 3 3 0 Homeodomain-like domain HTH_29 PF13551.6 ACS99685.1 - 0.075 13.1 0.1 15 5.7 0.0 3.1 3 0 0 3 3 3 0 Winged helix-turn helix GalKase_gal_bdg PF10509.9 ACS99686.1 - 1.4e-20 72.5 0.1 3.1e-20 71.5 0.1 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 ACS99686.1 - 1.5e-13 50.8 0.0 2.6e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ACS99686.1 - 7.5e-13 48.7 0.0 1.5e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal Epimerase PF01370.21 ACS99687.1 - 1.7e-59 201.2 0.2 2.1e-59 200.9 0.2 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACS99687.1 - 1.3e-56 192.4 0.0 1.6e-56 192.1 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ACS99687.1 - 4.2e-18 65.3 0.0 7.8e-15 54.6 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ACS99687.1 - 2.8e-17 62.8 2.5 1.3e-16 60.6 0.8 2.5 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ACS99687.1 - 1.1e-16 60.8 0.1 3.9e-16 59.0 0.1 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ACS99687.1 - 8.1e-09 35.6 0.0 1.4e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ACS99687.1 - 4.2e-06 26.1 0.1 0.00069 18.9 0.1 2.4 2 1 0 2 2 2 2 Male sterility protein KR PF08659.10 ACS99687.1 - 0.00081 19.3 0.6 0.021 14.7 0.6 2.3 1 1 0 1 1 1 1 KR domain UDPG_MGDP_dh_N PF03721.14 ACS99687.1 - 0.0019 17.8 0.2 0.0037 16.9 0.2 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NmrA PF05368.13 ACS99687.1 - 0.0028 17.2 0.2 0.034 13.7 0.1 2.2 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 ACS99687.1 - 0.003 17.0 0.9 0.0083 15.6 0.9 1.9 1 1 0 1 1 1 1 short chain dehydrogenase TrkA_N PF02254.18 ACS99687.1 - 0.026 14.8 0.3 0.052 13.8 0.3 1.5 1 0 0 1 1 1 0 TrkA-N domain DapB_N PF01113.20 ACS99687.1 - 0.045 13.9 0.2 0.12 12.5 0.2 1.8 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short_C2 PF13561.6 ACS99687.1 - 0.053 13.1 0.4 0.24 10.9 0.4 2.0 1 1 1 2 2 2 0 Enoyl-(Acyl carrier protein) reductase GalP_UDP_transf PF01087.22 ACS99688.1 - 1.6e-27 97.1 0.0 4.2e-27 95.8 0.0 1.7 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 ACS99688.1 - 2.2e-26 92.6 0.0 4e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain Tic110 PF16940.5 ACS99688.1 - 0.13 10.7 0.0 0.19 10.2 0.0 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF1128 PF06569.11 ACS99690.1 - 4.8e-33 113.0 0.9 5.4e-33 112.8 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1128) DUF1256 PF06866.11 ACS99691.1 - 3.8e-43 146.7 0.0 4.4e-43 146.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1256) Abhydrolase_1 PF00561.20 ACS99692.1 - 3.1e-27 95.9 0.0 2.7e-25 89.5 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ACS99692.1 - 1e-23 83.9 0.0 1.3e-23 83.6 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ACS99692.1 - 1.6e-23 84.5 0.0 2e-23 84.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 ACS99692.1 - 5.7e-11 41.7 0.0 7e-11 41.4 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_5 PF12695.7 ACS99692.1 - 5.5e-06 26.3 0.0 0.00032 20.5 0.0 2.3 1 1 1 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 ACS99692.1 - 1.2e-05 25.5 0.0 1.6e-05 25.2 0.0 1.3 1 1 0 1 1 1 1 Thioesterase domain Chlorophyllase2 PF12740.7 ACS99692.1 - 2.1e-05 23.6 0.0 3.5e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme AXE1 PF05448.12 ACS99692.1 - 0.0035 16.0 0.0 0.069 11.8 0.0 2.4 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) DLH PF01738.18 ACS99692.1 - 0.0056 16.3 0.0 3.5 7.1 0.0 3.2 3 0 0 3 3 3 1 Dienelactone hydrolase family LIDHydrolase PF10230.9 ACS99692.1 - 0.0065 16.1 0.0 0.01 15.4 0.0 1.4 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase Chlorophyllase PF07224.11 ACS99692.1 - 0.018 14.1 0.0 0.029 13.4 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Peptidase_S9 PF00326.21 ACS99692.1 - 0.021 14.3 0.0 0.5 9.8 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family UPF0227 PF05728.12 ACS99692.1 - 0.024 14.6 0.0 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Esterase PF00756.20 ACS99692.1 - 0.027 14.1 0.1 0.097 12.3 0.1 2.0 1 1 0 1 1 1 0 Putative esterase DUF676 PF05057.14 ACS99692.1 - 0.027 14.0 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.16 ACS99692.1 - 0.051 13.4 0.0 15 5.3 0.0 2.9 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF915 PF06028.11 ACS99692.1 - 0.12 11.6 0.0 0.82 8.9 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) BAAT_C PF08840.11 ACS99692.1 - 0.13 12.2 0.0 0.81 9.6 0.0 2.1 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Methyltransf_32 PF13679.6 ACS99694.1 - 4.7e-35 120.9 0.0 9.8e-35 119.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACS99694.1 - 1.8e-15 57.0 0.1 3.2e-15 56.2 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACS99694.1 - 7.2e-08 33.0 0.1 1.9e-07 31.7 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACS99694.1 - 2.2e-05 25.0 0.1 5.9e-05 23.6 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACS99694.1 - 7.3e-05 23.5 0.1 0.00017 22.3 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain TRM13 PF05206.14 ACS99694.1 - 0.00015 21.4 0.5 0.021 14.4 0.6 2.3 1 1 1 2 2 2 2 Methyltransferase TRM13 MTS PF05175.14 ACS99694.1 - 0.01 15.4 0.0 0.023 14.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 ACS99694.1 - 0.028 14.1 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 ACS99694.1 - 0.042 13.2 0.0 0.12 11.7 0.0 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family GGDEF PF00990.21 ACS99695.1 - 9.1e-41 139.3 0.0 2.2e-40 138.0 0.0 1.7 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain HisKA_7TM PF16927.5 ACS99695.1 - 9.2e-16 58.5 30.4 1.3e-15 58.1 30.4 1.2 1 0 0 1 1 1 1 N-terminal 7TM region of histidine kinase PAS PF00989.25 ACS99695.1 - 1e-07 32.0 0.0 2.2e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ACS99695.1 - 6.1e-05 23.2 0.0 0.00024 21.3 0.0 2.1 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 ACS99695.1 - 0.0033 17.6 0.0 0.0068 16.6 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 ACS99695.1 - 0.0094 16.0 0.0 0.24 11.5 0.0 2.8 2 0 0 2 2 2 1 PAS domain HD_5 PF13487.6 ACS99696.1 - 8.5e-15 54.8 0.1 1.5e-14 53.9 0.1 1.4 1 0 0 1 1 1 1 HD domain HD PF01966.22 ACS99696.1 - 4.6e-13 49.4 0.5 8.7e-13 48.6 0.5 1.5 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 ACS99696.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 HDOD domain YitT_membrane PF02588.15 ACS99698.1 - 3.6e-69 232.3 18.2 3.6e-69 232.3 18.2 1.3 2 0 0 2 2 2 1 Uncharacterised 5xTM membrane BCR, YitT family COG1284 DUF2179 PF10035.9 ACS99698.1 - 4.4e-21 74.4 0.1 7.6e-21 73.6 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2179) Polysacc_synt_C PF14667.6 ACS99698.1 - 3.1 7.8 17.3 0.23 11.5 12.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain AIRS PF00586.24 ACS99699.1 - 7.9e-22 77.7 0.8 1.7e-21 76.7 0.8 1.6 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.22 ACS99699.1 - 8.8e-13 48.7 0.5 1.4e-12 48.0 0.5 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain TsaE PF02367.17 ACS99700.1 - 2.7e-36 124.3 0.0 3.3e-36 124.0 0.0 1.1 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE PRK PF00485.18 ACS99700.1 - 0.05 13.4 0.0 0.059 13.1 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family dNK PF01712.19 ACS99700.1 - 0.052 13.4 0.0 0.07 13.0 0.0 1.2 1 0 0 1 1 1 0 Deoxynucleoside kinase NACHT PF05729.12 ACS99700.1 - 0.063 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 ACS99700.1 - 0.1 12.8 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 ACS99700.1 - 0.16 11.3 0.1 0.23 10.8 0.1 1.2 1 0 0 1 1 1 0 KaiC Peptidase_M22 PF00814.25 ACS99701.1 - 5.8e-25 88.5 0.4 2.6e-24 86.4 0.4 1.9 1 1 0 1 1 1 1 Glycoprotease family Acetyltransf_1 PF00583.25 ACS99702.1 - 9.4e-19 67.8 0.1 1.2e-18 67.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACS99702.1 - 3.8e-15 56.0 0.0 4.8e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACS99702.1 - 7.8e-15 55.1 0.1 1.1e-14 54.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACS99702.1 - 7.8e-08 32.2 0.0 1.3e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 ACS99702.1 - 3.1e-07 30.6 0.0 3.6e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACS99702.1 - 7.9e-06 26.0 0.0 0.00042 20.4 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACS99702.1 - 1.5e-05 25.7 0.1 2e-05 25.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 ACS99702.1 - 0.0099 15.6 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_8 PF13523.6 ACS99702.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 ACS99702.1 - 0.097 12.2 0.0 0.15 11.6 0.0 1.3 1 1 0 1 1 1 0 GNAT acetyltransferase Peptidase_M22 PF00814.25 ACS99703.1 - 1.5e-96 323.3 0.4 1.7e-96 323.1 0.4 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 ACS99703.1 - 0.019 14.6 0.2 0.052 13.2 0.1 1.7 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus ASL_C2 PF14698.6 ACS99703.1 - 0.08 13.7 0.2 0.4 11.5 0.1 2.2 2 0 0 2 2 2 0 Argininosuccinate lyase C-terminal HMGL-like PF00682.19 ACS99705.1 - 1.4e-86 290.4 3.6 1.4e-86 290.4 3.6 1.8 2 1 0 2 2 2 1 HMGL-like LeuA_dimer PF08502.10 ACS99705.1 - 6.9e-25 87.5 1.5 8.9e-25 87.1 0.2 1.9 2 0 0 2 2 2 1 LeuA allosteric (dimerisation) domain NolV PF06635.12 ACS99705.1 - 0.072 12.5 0.5 0.19 11.1 0.0 1.8 2 0 0 2 2 2 0 Nodulation protein NolV ABC_tran PF00005.27 ACS99706.1 - 2e-31 109.4 0.0 3.3e-31 108.6 0.0 1.4 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 ACS99706.1 - 1e-08 35.4 0.0 0.00017 21.5 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS99706.1 - 0.0016 17.9 0.1 0.042 13.3 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ACS99706.1 - 0.0021 18.6 0.3 0.0039 17.7 0.1 1.5 2 0 0 2 2 1 1 AAA domain AAA_29 PF13555.6 ACS99706.1 - 0.0052 16.5 0.0 0.0091 15.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACS99706.1 - 0.011 15.6 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 ACS99706.1 - 0.012 15.4 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 ACS99706.1 - 0.013 15.4 0.2 0.037 13.9 0.1 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_2 PF07724.14 ACS99706.1 - 0.014 15.5 0.0 0.4 10.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) cobW PF02492.19 ACS99706.1 - 0.018 14.7 0.2 0.05 13.2 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 ACS99706.1 - 0.021 15.1 0.2 0.17 12.1 0.2 2.1 1 1 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 ACS99706.1 - 0.022 15.0 0.0 0.28 11.4 0.0 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Roc PF08477.13 ACS99706.1 - 0.037 14.3 0.0 0.078 13.2 0.0 1.6 2 0 0 2 2 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 ACS99706.1 - 0.043 14.0 0.0 0.075 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ACS99706.1 - 0.047 13.9 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ACS99706.1 - 0.048 13.7 0.0 0.096 12.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ACS99706.1 - 0.053 13.9 0.1 0.077 13.4 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 ACS99706.1 - 0.059 13.1 0.0 0.31 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ACS99706.1 - 0.067 12.9 0.0 2.5 7.7 0.0 2.1 1 1 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 ACS99706.1 - 0.13 12.8 0.7 0.4 11.2 0.5 1.9 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ACS99706.1 - 0.13 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region MeaB PF03308.16 ACS99706.1 - 0.15 11.0 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 ACS99706.1 - 0.19 11.8 0.0 0.47 10.6 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF3545 PF12065.8 ACS99707.1 - 0.066 13.2 0.5 0.1 12.6 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3545) polyprenyl_synt PF00348.17 ACS99708.1 - 7.8e-19 67.7 3.4 1.2e-18 67.1 3.4 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase ComX PF05952.12 ACS99709.1 - 4.1e-08 33.0 0.1 4.3e-08 33.0 0.1 1.0 1 0 0 1 1 1 1 Bacillus competence pheromone ComX PDZ PF00595.24 ACS99710.1 - 1.1e-05 25.7 0.0 1.5e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ACS99710.1 - 0.00044 20.5 0.0 0.00058 20.1 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ACS99710.1 - 0.0018 18.1 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_4 PF17816.1 ACS99710.1 - 0.048 14.1 0.0 0.059 13.8 0.0 1.1 1 0 0 1 1 1 0 PDZ domain HATPase_c PF02518.26 ACS99711.1 - 7.5e-11 42.5 0.0 2e-10 41.1 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA_3 PF07730.13 ACS99711.1 - 4.9e-06 27.0 0.0 1.1e-05 25.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase HATPase_c_3 PF13589.6 ACS99711.1 - 0.00016 21.5 0.0 0.00028 20.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACS99711.1 - 0.0007 19.5 0.1 0.0045 16.9 0.0 2.3 2 1 1 3 3 3 1 Histidine kinase-like ATPase domain Response_reg PF00072.24 ACS99712.1 - 7.2e-25 87.3 0.2 1.5e-24 86.3 0.0 1.6 2 0 0 2 2 2 1 Response regulator receiver domain GerE PF00196.19 ACS99712.1 - 1e-15 57.0 0.3 1.8e-15 56.2 0.3 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACS99712.1 - 3.8e-06 26.5 0.0 8.3e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 ACS99712.1 - 0.00025 20.7 0.0 0.00061 19.5 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 ACS99712.1 - 0.0016 18.5 0.0 0.0033 17.5 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 ACS99712.1 - 0.0017 17.9 0.1 0.0068 15.9 0.1 2.1 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Sigma70_ECF PF07638.11 ACS99712.1 - 0.0055 16.6 0.1 0.0074 16.2 0.1 1.3 1 0 0 1 1 1 1 ECF sigma factor HTH_30 PF13556.6 ACS99712.1 - 0.0092 15.8 0.0 0.027 14.3 0.0 1.7 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain DUF2840 PF11000.8 ACS99712.1 - 0.055 13.3 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2840) DUF2556 PF10831.8 ACS99713.1 - 0.0084 16.0 1.4 0.0084 16.0 1.4 2.1 2 1 1 3 3 3 1 Protein of unknown function (DUF2556) Claudin_2 PF13903.6 ACS99713.1 - 0.21 11.3 3.3 0.26 11.0 3.3 1.4 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction ABC_tran PF00005.27 ACS99714.1 - 7.3e-58 194.9 7.6 1.8e-28 99.8 0.0 3.5 4 0 0 4 4 3 2 ABC transporter ABC_tran_Xtn PF12848.7 ACS99714.1 - 1.2e-25 89.3 7.6 1.2e-25 89.3 7.6 4.0 3 1 1 4 4 4 2 ABC transporter ABC_tran_CTD PF16326.5 ACS99714.1 - 5.7e-16 58.5 31.2 1.3e-14 54.1 12.6 4.2 4 0 0 4 4 4 2 ABC transporter C-terminal domain AAA_21 PF13304.6 ACS99714.1 - 1.4e-14 54.7 12.9 0.00071 19.5 0.1 4.5 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ACS99714.1 - 1.2e-11 44.8 0.5 1.8e-06 28.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 ACS99714.1 - 1.6e-11 44.0 0.0 0.00065 19.2 0.0 4.4 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACS99714.1 - 2.1e-08 33.8 0.3 0.00063 19.4 0.0 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ACS99714.1 - 1.9e-06 28.4 1.4 0.057 13.8 0.1 2.9 2 1 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 ACS99714.1 - 8.9e-06 26.0 0.2 0.1 12.9 0.1 3.1 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ACS99714.1 - 1.4e-05 25.1 2.7 0.15 12.2 0.1 3.1 2 1 0 2 2 2 2 50S ribosome-binding GTPase MeaB PF03308.16 ACS99714.1 - 2.5e-05 23.4 0.1 0.052 12.5 0.0 2.6 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 ACS99714.1 - 9.4e-05 22.6 4.3 0.47 10.6 0.0 3.9 4 1 0 4 4 4 2 AAA domain NACHT PF05729.12 ACS99714.1 - 0.00013 21.9 1.0 0.21 11.5 0.1 2.6 2 0 0 2 2 2 2 NACHT domain AAA PF00004.29 ACS99714.1 - 0.00016 22.1 0.0 0.69 10.3 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 ACS99714.1 - 0.0002 21.2 8.6 0.016 15.0 0.0 3.8 4 0 0 4 4 4 2 AAA ATPase domain AAA_18 PF13238.6 ACS99714.1 - 0.00048 20.7 1.3 0.093 13.3 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_23 PF13476.6 ACS99714.1 - 0.0005 20.6 25.8 0.14 12.6 0.0 4.7 3 1 0 3 3 3 1 AAA domain AAA_30 PF13604.6 ACS99714.1 - 0.0012 18.6 0.1 1.7 8.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 ACS99714.1 - 0.002 18.1 0.0 1.7 8.5 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain G-alpha PF00503.20 ACS99714.1 - 0.0031 16.7 3.0 0.057 12.6 3.0 3.0 1 1 0 1 1 1 1 G-protein alpha subunit AAA_24 PF13479.6 ACS99714.1 - 0.0032 17.2 1.4 0.62 9.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.12 ACS99714.1 - 0.0038 17.0 0.1 7.3 6.3 0.0 3.5 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ACS99714.1 - 0.0062 16.9 0.3 3.2 8.2 0.0 2.7 2 0 0 2 2 2 1 RNA helicase TsaE PF02367.17 ACS99714.1 - 0.0089 16.0 0.1 7.4 6.6 0.0 2.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 ACS99714.1 - 0.01 16.1 0.2 1.1 9.5 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 ACS99714.1 - 0.012 14.8 0.2 3.4 6.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_14 PF13173.6 ACS99714.1 - 0.014 15.4 3.3 4.5 7.3 0.1 3.6 4 0 0 4 4 2 0 AAA domain IstB_IS21 PF01695.17 ACS99714.1 - 0.014 15.1 0.1 0.46 10.2 0.0 3.1 3 0 0 3 3 2 0 IstB-like ATP binding protein Dynamin_N PF00350.23 ACS99714.1 - 0.015 15.4 7.2 3 7.9 0.0 4.0 4 0 0 4 4 4 0 Dynamin family NB-ARC PF00931.22 ACS99714.1 - 0.037 13.2 5.6 2 7.5 0.1 3.1 4 0 0 4 4 3 0 NB-ARC domain Septin PF00735.18 ACS99714.1 - 0.044 13.1 1.1 5.4 6.2 0.0 3.0 3 0 0 3 3 3 0 Septin cobW PF02492.19 ACS99714.1 - 0.056 13.0 0.8 7.3 6.1 0.0 2.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 ACS99714.1 - 0.058 13.0 1.2 1.6 8.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 ACS99714.1 - 0.077 12.5 0.1 4.3 6.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 ACS99714.1 - 0.082 13.1 10.4 1.6 9.0 0.0 3.9 4 1 0 4 4 3 0 AAA domain FeoB_N PF02421.18 ACS99714.1 - 0.1 12.1 0.2 4.1 6.9 0.0 2.8 2 0 0 2 2 2 0 Ferrous iron transport protein B MukB PF04310.12 ACS99714.1 - 0.11 12.3 1.7 23 4.7 0.0 3.8 4 0 0 4 4 4 0 MukB N-terminal AAA_5 PF07728.14 ACS99714.1 - 0.11 12.4 1.0 8 6.5 0.1 3.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 ACS99714.1 - 0.13 12.0 0.2 20 4.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 ACS99714.1 - 0.22 11.4 4.1 17 5.3 0.3 3.5 4 0 0 4 4 4 0 NTPase AAA_27 PF13514.6 ACS99714.1 - 0.23 11.0 3.3 19 4.7 0.0 3.5 3 0 0 3 3 3 0 AAA domain DUF4094 PF13334.6 ACS99714.1 - 1.3 9.5 4.2 1 9.8 1.2 2.3 2 0 0 2 2 1 0 Domain of unknown function (DUF4094) Lzipper-MIP1 PF14389.6 ACS99714.1 - 1.8 8.9 13.9 0.11 12.9 4.2 3.7 4 1 1 5 5 3 0 Leucine-zipper of ternary complex factor MIP1 ATPase_2 PF01637.18 ACS99714.1 - 2.2 8.1 9.3 2.9 7.7 0.0 3.8 4 0 0 4 4 4 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 ACS99714.1 - 4.4 7.6 6.2 12 6.2 0.2 3.7 3 1 1 4 4 3 0 AAA domain PCRF PF03462.18 ACS99714.1 - 5.3 6.9 15.6 3 7.6 0.0 4.0 3 1 1 4 4 4 0 PCRF domain Spectrin PF00435.21 ACS99714.1 - 6.6 7.3 14.7 0.22 12.0 4.9 2.7 3 0 0 3 3 2 0 Spectrin repeat YlqD PF11068.8 ACS99714.1 - 9.1 6.7 19.4 1.6 9.1 1.0 2.9 3 1 1 4 4 3 0 YlqD protein DUF2203 PF09969.9 ACS99714.1 - 9.9 6.9 12.1 17 6.1 2.9 3.6 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) 5-FTHF_cyc-lig PF01812.20 ACS99715.1 - 4.4e-36 124.5 0.0 5.1e-36 124.3 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family MoaC PF01967.21 ACS99716.1 - 1.1e-56 190.7 2.3 1.2e-56 190.5 2.3 1.0 1 0 0 1 1 1 1 MoaC family RL11D PF11088.8 ACS99716.1 - 0.027 14.7 0.1 0.059 13.7 0.0 1.6 2 0 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 DUF5318 PF17249.2 ACS99716.1 - 0.047 13.5 0.0 0.08 12.7 0.0 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5318) MoCF_biosynth PF00994.24 ACS99717.1 - 8.5e-36 122.8 0.2 9.8e-36 122.6 0.2 1.0 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoCF_biosynth PF00994.24 ACS99718.1 - 2e-19 69.7 0.0 4.5e-19 68.5 0.0 1.6 2 0 0 2 2 2 1 Probable molybdopterin binding domain MttA_Hcf106 PF02416.16 ACS99719.1 - 3.2e-18 64.8 0.1 4.4e-18 64.3 0.1 1.2 1 0 0 1 1 1 1 mttA/Hcf106 family TatC PF00902.18 ACS99720.1 - 1.7e-54 184.8 21.1 2.1e-54 184.5 21.1 1.0 1 0 0 1 1 1 1 Sec-independent protein translocase protein (TatC) UL45 PF05473.12 ACS99720.1 - 2.2 7.8 3.3 10 5.7 0.0 3.1 4 0 0 4 4 4 0 UL45 protein, carbohydrate-binding C-type lectin-like FtsX PF02687.21 ACS99720.1 - 8.9 6.9 24.8 0.12 12.8 3.0 3.0 2 1 1 3 3 3 0 FtsX-like permease family NTP_transferase PF00483.23 ACS99721.1 - 8.8e-68 228.5 0.0 1.1e-67 228.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACS99721.1 - 5.4e-07 30.1 0.0 8.3e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 ACS99721.1 - 2.3e-05 23.9 7.6 0.00049 19.7 3.1 3.2 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 ACS99721.1 - 0.013 13.7 0.2 0.018 13.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Fucokinase PF07959.12 ACS99721.1 - 0.088 11.7 0.0 0.91 8.4 0.1 2.0 2 0 0 2 2 2 0 L-fucokinase Hexapep_2 PF14602.6 ACS99721.1 - 3.1 7.6 6.1 13 5.7 2.7 3.1 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase Alpha-amylase_C PF02806.18 ACS99722.1 - 3.2e-20 72.4 0.0 8.8e-20 71.0 0.0 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 ACS99722.1 - 5.3e-16 58.7 0.0 1.2e-15 57.6 0.0 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 ACS99722.1 - 7.4e-12 45.5 0.0 1.9e-07 30.9 0.0 2.4 1 1 0 2 2 2 2 Alpha amylase, catalytic domain Glyco_transf_5 PF08323.11 ACS99723.1 - 2.1e-87 292.9 0.0 2.9e-87 292.4 0.0 1.2 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 ACS99723.1 - 1.8e-17 63.4 0.0 3.5e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99723.1 - 5e-12 46.4 0.0 9.9e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ACS99723.1 - 2.9e-09 37.6 2.4 7e-07 29.8 1.3 2.8 3 1 0 3 3 3 2 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 ACS99723.1 - 5.4e-08 33.0 0.6 1.7e-07 31.4 0.6 2.0 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Alpha-amylase PF00128.24 ACS99724.1 - 9.9e-79 265.3 0.0 2.3e-78 264.1 0.0 1.6 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Alpha-amylase_N PF02903.14 ACS99724.1 - 3.8e-37 127.1 0.6 2e-36 124.8 0.3 2.1 2 0 0 2 2 2 1 Alpha amylase, N-terminal ig-like domain Malt_amylase_C PF16657.5 ACS99724.1 - 3.4e-12 46.3 0.0 6.7e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain DUF3459 PF11941.8 ACS99724.1 - 0.00021 21.6 0.0 0.00047 20.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) Glyco_hydro_42C PF08533.10 ACS99724.1 - 0.00076 19.1 0.0 0.002 17.8 0.0 1.7 1 0 0 1 1 1 1 Beta-galactosidase C-terminal domain hDGE_amylase PF14701.6 ACS99724.1 - 0.002 17.3 0.0 0.0031 16.7 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GHL6 PF14871.6 ACS99724.1 - 0.003 17.7 0.0 0.01 16.0 0.0 1.8 2 0 0 2 2 2 1 Hypothetical glycosyl hydrolase 6 Glyco_hydro_66 PF13199.6 ACS99724.1 - 0.058 12.0 0.2 0.085 11.5 0.2 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 ComA PF02679.15 ACS99724.1 - 0.23 10.9 0.0 0.39 10.1 0.0 1.3 1 0 0 1 1 1 0 (2R)-phospho-3-sulfolactate synthase (ComA) adh_short_C2 PF13561.6 ACS99725.1 - 4e-64 216.4 0.1 5.1e-64 216.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACS99725.1 - 1.6e-55 187.6 0.3 1.9e-55 187.4 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACS99725.1 - 4.4e-13 49.5 0.3 5.8e-13 49.2 0.3 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ACS99725.1 - 0.00022 20.7 0.0 0.00028 20.3 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 ACS99725.1 - 0.0023 17.5 0.1 0.0032 17.0 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ACS99725.1 - 0.012 14.7 0.1 0.016 14.3 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 2-Hacid_dh_C PF02826.19 ACS99725.1 - 0.022 14.2 0.4 0.13 11.6 0.2 2.0 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 ACS99725.1 - 0.066 13.9 0.0 0.13 13.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TrkA_N PF02254.18 ACS99725.1 - 0.091 13.0 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain THF_DHG_CYH_C PF02882.19 ACS99725.1 - 0.1 11.9 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ABC2_membrane_3 PF12698.7 ACS99727.1 - 1.3e-25 90.2 13.1 1.8e-25 89.8 13.1 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF3533 PF12051.8 ACS99727.1 - 1.3e-21 77.0 10.3 1.8e-21 76.5 10.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) ABC2_membrane PF01061.24 ACS99727.1 - 0.0063 15.9 18.8 0.0063 15.9 18.8 2.6 3 1 0 3 3 3 1 ABC-2 type transporter FKBP_N PF01346.18 ACS99727.1 - 2.9 8.9 5.5 0.69 10.9 0.8 2.3 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase TetR_N PF00440.23 ACS99728.1 - 1.6e-13 50.2 0.1 2.7e-13 49.5 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_29 PF17938.1 ACS99728.1 - 1.3e-05 25.3 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_24 PF17932.1 ACS99728.1 - 0.015 15.5 0.0 0.026 14.8 0.0 1.5 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Cpn10 PF00166.21 ACS99729.1 - 8.3e-36 121.9 0.2 9e-36 121.8 0.2 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Cpn60_TCP1 PF00118.24 ACS99730.1 - 3.8e-105 352.3 19.0 5.5e-105 351.8 19.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FtsA PF14450.6 ACS99730.1 - 1.8 9.0 6.0 0.32 11.4 0.7 2.4 3 1 0 3 3 3 0 Cell division protein FtsA ATP-cone PF03477.16 ACS99730.1 - 2.6 8.7 4.7 56 4.4 0.1 3.4 2 1 0 2 2 2 0 ATP cone domain DinB_2 PF12867.7 ACS99731.1 - 8.2e-15 55.4 0.1 9.8e-15 55.2 0.1 1.1 1 0 0 1 1 1 1 DinB superfamily DinB PF05163.12 ACS99731.1 - 0.00094 19.1 0.1 0.0011 18.9 0.1 1.1 1 0 0 1 1 1 1 DinB family DUF664 PF04978.12 ACS99731.1 - 0.032 14.6 0.0 0.044 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF664) Pribosyltran PF00156.27 ACS99732.1 - 1.3e-12 47.5 0.2 1.9e-12 47.0 0.2 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ACS99732.1 - 0.0025 17.3 0.0 0.0042 16.6 0.0 1.4 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 ACS99732.1 - 0.024 14.1 0.1 0.028 13.9 0.1 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase OmpA_membrane PF01389.17 ACS99732.1 - 0.029 14.1 0.0 0.039 13.7 0.0 1.1 1 0 0 1 1 1 0 OmpA-like transmembrane domain TIP41 PF04176.13 ACS99732.1 - 0.17 11.3 0.6 7.9 5.9 0.0 2.1 1 1 1 2 2 2 0 TIP41-like family Xan_ur_permease PF00860.20 ACS99733.1 - 1.1e-113 379.9 45.5 1.4e-113 379.6 45.5 1.1 1 0 0 1 1 1 1 Permease family TMF_DNA_bd PF12329.8 ACS99734.1 - 0.0012 18.8 14.6 0.053 13.5 3.7 2.1 2 0 0 2 2 2 2 TATA element modulatory factor 1 DNA binding SHE3 PF17078.5 ACS99734.1 - 0.0022 17.8 4.8 0.0041 16.9 4.8 1.4 1 1 0 1 1 1 1 SWI5-dependent HO expression protein 3 Rootletin PF15035.6 ACS99734.1 - 0.021 14.9 3.3 0.023 14.7 3.3 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion MIP-T3_C PF17749.1 ACS99734.1 - 0.032 14.2 8.2 0.036 14.0 1.7 2.1 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region DivIC PF04977.15 ACS99734.1 - 0.033 14.0 1.2 0.033 14.0 1.2 2.2 2 1 0 2 2 2 0 Septum formation initiator ADIP PF11559.8 ACS99734.1 - 0.049 13.7 1.1 0.049 13.7 1.1 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding SlyX PF04102.12 ACS99734.1 - 0.053 14.1 4.5 0.064 13.9 0.4 2.1 1 1 1 2 2 2 0 SlyX FapA PF03961.13 ACS99734.1 - 0.093 11.3 7.3 0.097 11.3 7.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A TRAF_BIRC3_bd PF16673.5 ACS99734.1 - 0.33 10.8 3.9 0.23 11.3 1.7 1.8 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain ZapB PF06005.12 ACS99734.1 - 0.45 11.0 8.2 0.92 10.0 0.2 2.1 2 0 0 2 2 2 0 Cell division protein ZapB FAM76 PF16046.5 ACS99734.1 - 0.5 9.7 6.8 0.6 9.4 6.8 1.1 1 0 0 1 1 1 0 FAM76 protein DUF4200 PF13863.6 ACS99734.1 - 0.6 10.5 9.8 3.2 8.2 3.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Snapin_Pallidin PF14712.6 ACS99734.1 - 0.9 10.0 11.1 0.38 11.2 3.0 2.3 2 1 0 2 2 2 0 Snapin/Pallidin NPV_P10 PF05531.12 ACS99734.1 - 1.3 9.6 7.8 1.7 9.1 2.2 2.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein ABC_tran_CTD PF16326.5 ACS99734.1 - 2.3 8.5 7.4 1.2e+02 3.1 7.5 2.4 1 1 0 1 1 1 0 ABC transporter C-terminal domain LPP PF04728.13 ACS99734.1 - 3.2 8.2 10.3 7.6 7.0 1.9 2.6 2 1 0 2 2 2 0 Lipoprotein leucine-zipper SBP_bac_3 PF00497.20 ACS99735.1 - 5.1e-57 192.9 2.9 6.4e-57 192.6 2.9 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 ACS99735.1 - 9.3e-09 35.5 0.3 2.3e-07 31.0 0.1 2.8 2 1 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site Myco_arth_vir_N PF09610.10 ACS99735.1 - 0.0045 17.0 1.1 0.012 15.7 1.1 1.7 1 0 0 1 1 1 1 Mycoplasma virulence signal region (Myco_arth_vir_N) NMT1 PF09084.11 ACS99735.1 - 0.0054 16.7 0.8 0.015 15.3 0.7 1.7 1 1 1 2 2 2 1 NMT1/THI5 like BPD_transp_1 PF00528.22 ACS99736.1 - 1.6e-21 76.9 12.8 2e-21 76.5 12.8 1.2 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 ACS99737.1 - 7.6e-35 120.4 0.0 9.6e-35 120.1 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACS99737.1 - 4.9e-13 49.5 0.0 4.9e-06 26.6 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS99737.1 - 3.7e-09 36.3 0.2 2.1e-08 33.9 0.2 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ACS99737.1 - 3.9e-06 26.8 0.0 0.025 14.3 0.0 2.1 1 1 1 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 ACS99737.1 - 0.00014 21.5 0.0 0.00026 20.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ACS99737.1 - 0.00032 21.0 0.1 0.0015 18.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACS99737.1 - 0.00062 20.2 0.1 0.00079 19.8 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ACS99737.1 - 0.001 19.0 0.1 0.0017 18.3 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 ACS99737.1 - 0.0014 18.8 0.1 0.0026 17.9 0.1 1.7 1 1 0 1 1 1 1 AAA domain G-alpha PF00503.20 ACS99737.1 - 0.0024 17.1 0.0 0.0024 17.1 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_23 PF13476.6 ACS99737.1 - 0.0044 17.5 0.1 0.0061 17.1 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ACS99737.1 - 0.005 16.6 0.0 0.0072 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ACS99737.1 - 0.0055 16.3 0.1 0.069 12.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 ACS99737.1 - 0.0081 15.0 0.0 1.7 7.3 0.0 2.3 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_13 PF13166.6 ACS99737.1 - 0.0095 14.6 0.0 0.15 10.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 ACS99737.1 - 0.021 13.9 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.6 ACS99737.1 - 0.021 15.4 0.0 0.035 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ACS99737.1 - 0.026 14.7 0.1 0.48 10.7 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 ACS99737.1 - 0.029 14.1 0.1 0.042 13.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ACS99737.1 - 0.034 13.5 0.1 0.077 12.3 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family CobU PF02283.16 ACS99737.1 - 0.045 13.3 0.0 2.3 7.8 0.0 2.2 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase NACHT PF05729.12 ACS99737.1 - 0.051 13.5 0.0 0.098 12.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 ACS99737.1 - 0.079 12.9 0.1 0.16 11.8 0.1 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA PF00004.29 ACS99737.1 - 0.082 13.3 0.0 12 6.3 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ACS99737.1 - 0.12 11.7 0.0 0.59 9.5 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 ACS99737.1 - 0.12 12.7 0.2 0.16 12.3 0.2 1.4 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ACS99737.1 - 0.12 12.4 0.0 0.52 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ACS99737.1 - 0.15 12.3 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain oligo_HPY PF08352.12 ACS99737.1 - 0.16 12.5 0.0 0.31 11.6 0.0 1.4 1 0 0 1 1 1 0 Oligopeptide/dipeptide transporter, C-terminal region Alk_phosphatase PF00245.20 ACS99738.1 - 2e-89 300.5 10.6 5.2e-86 289.2 10.6 2.1 1 1 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 ACS99738.1 - 1.2e-09 37.9 0.4 1.8e-08 34.1 0.1 2.1 2 0 0 2 2 2 1 Metalloenzyme superfamily DUF1729 PF08354.10 ACS99738.1 - 0.0017 17.3 0.3 0.003 16.5 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) CAP PF00188.26 ACS99739.1 - 7e-22 78.6 0.0 9.7e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Myb_DNA-bind_6 PF13921.6 ACS99739.1 - 0.091 13.0 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Myb-like DNA-binding domain GAF_2 PF13185.6 ACS99740.1 - 5.6e-13 49.4 0.0 6.9e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 ACS99740.1 - 8.3e-09 36.2 0.0 9.8e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 ACS99740.1 - 3.5e-06 27.4 0.0 4.3e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 GAF domain YjcZ_2 PF09680.10 ACS99741.1 - 1.5e-05 24.6 10.1 1.5e-05 24.6 10.1 1.8 2 0 0 2 2 2 1 Family of unknown function Cortexin PF11057.8 ACS99741.1 - 0.045 13.6 0.1 0.045 13.6 0.1 1.0 1 0 0 1 1 1 0 Cortexin of kidney cobW PF02492.19 ACS99742.1 - 2e-44 151.3 0.1 3e-44 150.7 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ACS99742.1 - 8.9e-11 41.6 0.0 1.8e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.14 ACS99742.1 - 0.00023 21.1 0.0 0.00081 19.3 0.0 1.9 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 ACS99742.1 - 0.00035 19.6 0.1 0.0012 17.9 0.1 1.8 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 ACS99742.1 - 0.0039 17.6 0.0 0.01 16.2 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 ACS99742.1 - 0.0074 16.2 1.4 0.021 14.8 1.3 1.9 1 1 0 1 1 1 1 NACHT domain TsaE PF02367.17 ACS99742.1 - 0.016 15.2 0.2 0.038 14.0 0.2 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 ACS99742.1 - 0.017 14.0 0.0 0.03 13.2 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.6 ACS99742.1 - 0.025 14.3 0.0 0.069 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ACS99742.1 - 0.06 13.5 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 ACS99742.1 - 0.093 12.4 0.5 0.2 11.2 0.1 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Poly_export PF02563.16 ACS99743.1 - 0.063 13.5 0.2 14 6.0 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis/export protein SAP PF02037.27 ACS99743.1 - 0.11 12.2 2.0 3.4 7.5 0.3 3.1 2 1 1 3 3 3 0 SAP domain DUF4148 PF13663.6 ACS99743.1 - 0.22 11.8 4.6 1.5 9.0 2.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4148) EAL PF00563.20 ACS99744.1 - 7e-76 254.9 0.1 1.3e-75 254.0 0.1 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 ACS99744.1 - 1.1e-30 106.5 0.0 3e-30 105.1 0.0 1.7 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain dCache_1 PF02743.18 ACS99744.1 - 1.3e-16 61.2 2.4 2.7e-16 60.1 2.4 1.5 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 ACS99744.1 - 0.00086 19.6 0.0 0.002 18.5 0.0 1.7 1 0 0 1 1 1 1 HAMP domain TALPID3 PF15324.6 ACS99745.1 - 1.7 6.2 6.2 2 6.0 6.2 1.0 1 0 0 1 1 1 0 Hedgehog signalling target PT PF04886.12 ACS99745.1 - 2.6 7.6 24.8 4.2 7.0 24.8 1.3 1 0 0 1 1 1 0 PT repeat HTH_18 PF12833.7 ACS99746.1 - 1.1e-17 64.0 0.0 2e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99746.1 - 7.2e-17 61.0 0.3 8.4e-11 41.7 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family VirArc_Nuclease PF12187.8 ACS99746.1 - 0.002 17.7 1.1 0.005 16.4 1.1 1.6 1 0 0 1 1 1 1 Viral/Archaeal nuclease Cupin_2 PF07883.11 ACS99746.1 - 0.0021 17.8 0.0 0.0037 16.9 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_4 PF08007.12 ACS99746.1 - 0.1 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Cupin superfamily protein PK PF00224.21 ACS99747.1 - 1.1e-137 458.6 8.8 1.4e-137 458.3 8.8 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 ACS99747.1 - 7.3e-33 113.3 0.2 2.7e-32 111.4 0.1 2.1 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 ACS99747.1 - 0.0021 17.2 0.3 0.0093 15.1 0.1 2.1 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family SNARE_assoc PF09335.11 ACS99748.1 - 1.8e-14 54.2 4.4 1.8e-14 54.2 4.4 1.9 2 1 0 2 2 2 1 SNARE associated Golgi protein BatA PF07584.11 ACS99748.1 - 0.012 16.0 0.1 0.038 14.4 0.1 1.9 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal DUF4381 PF14316.6 ACS99748.1 - 0.07 13.4 0.2 0.12 12.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Pam17 PF08566.10 ACS99748.1 - 0.089 12.6 0.2 0.23 11.3 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 DUF3306 PF11748.8 ACS99748.1 - 1.6 9.6 5.4 2.3 9.1 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Asparaginase PF00710.20 ACS99749.1 - 3.3e-47 160.5 0.4 5.7e-47 159.7 0.4 1.4 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 ACS99749.1 - 2.7e-16 59.8 0.1 7.7e-16 58.3 0.1 1.8 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain PliI PF16743.5 ACS99749.1 - 0.039 13.7 0.9 0.064 13.0 0.1 1.7 2 0 0 2 2 2 0 Periplasmic lysozyme inhibitor of I-type lysozyme PT PF04886.12 ACS99749.1 - 0.23 11.0 3.9 0.57 9.8 3.9 1.6 1 0 0 1 1 1 0 PT repeat Asparaginase PF00710.20 ACS99750.1 - 4.7e-46 156.8 0.4 8.3e-46 155.9 0.4 1.4 1 0 0 1 1 1 1 Asparaginase, N-terminal SLH PF00395.20 ACS99750.1 - 1.1e-40 137.4 7.5 3.8e-14 52.4 0.1 4.3 4 0 0 4 4 4 3 S-layer homology domain Asparaginase_C PF17763.1 ACS99750.1 - 1.5e-19 70.3 0.3 8.1e-19 67.9 0.1 2.5 2 0 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain fn3 PF00041.21 ACS99750.1 - 0.0021 18.4 0.0 0.0044 17.3 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain DUF4367 PF14285.6 ACS99751.1 - 0.0057 17.1 1.3 0.081 13.4 0.0 3.2 3 1 0 4 4 4 1 Domain of unknown function (DUF4367) PPP4R2 PF09184.11 ACS99751.1 - 0.074 12.6 13.1 0.12 12.0 13.1 1.3 1 0 0 1 1 1 0 PPP4R2 Ala_racemase_N PF01168.20 ACS99752.1 - 1.3e-62 211.3 0.3 1.6e-62 211.0 0.3 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ala_racemase_C PF00842.21 ACS99752.1 - 3e-44 149.8 0.1 4.6e-44 149.2 0.1 1.3 1 0 0 1 1 1 1 Alanine racemase, C-terminal domain T2SS-T3SS_pil_N PF13629.6 ACS99752.1 - 0.13 12.0 0.3 5.8 6.7 0.0 2.4 2 0 0 2 2 2 0 Pilus formation protein N terminal region RHH_1 PF01402.21 ACS99753.1 - 5.8e-09 35.6 0.1 9.9e-09 34.8 0.1 1.4 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family HicB_lk_antitox PF15919.5 ACS99753.1 - 6.3e-06 26.3 0.0 1.2e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 HicB_like antitoxin of bacterial toxin-antitoxin system RHH_5 PF07878.11 ACS99753.1 - 0.0019 18.0 0.0 0.0036 17.2 0.0 1.5 1 0 0 1 1 1 1 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 RHH_8 PF17723.1 ACS99753.1 - 0.0035 17.5 0.2 0.0037 17.4 0.2 1.1 1 0 0 1 1 1 1 Ribbon-Helix-Helix transcriptional regulator family VapB_antitoxin PF09957.9 ACS99753.1 - 0.05 13.5 0.6 0.14 12.1 0.6 1.7 1 1 0 1 1 1 0 Bacterial antitoxin of type II TA system, VapB PemK_toxin PF02452.17 ACS99754.1 - 2.6e-33 114.8 0.1 2.8e-33 114.6 0.1 1.0 1 0 0 1 1 1 1 PemK-like, MazF-like toxin of type II toxin-antitoxin system CcdB PF01845.17 ACS99754.1 - 0.07 13.4 0.1 0.095 12.9 0.1 1.1 1 0 0 1 1 1 0 CcdB protein ChapFlgA PF13144.6 ACS99755.1 - 5.7e-05 23.2 0.0 0.00026 21.0 0.0 2.0 2 0 0 2 2 2 1 Chaperone for flagella basal body P-ring formation SAF PF08666.12 ACS99755.1 - 0.00038 21.0 0.1 0.0013 19.4 0.1 1.8 2 0 0 2 2 2 1 SAF domain MazE_antitoxin PF04014.18 ACS99755.1 - 0.021 14.7 0.0 0.75 9.8 0.0 2.5 2 0 0 2 2 2 0 Antidote-toxin recognition MazE, bacterial antitoxin RcpC PF16976.5 ACS99755.1 - 0.1 12.7 0.1 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 Flp pilus assembly protein RcpC/CpaB PTS-HPr PF00381.19 ACS99755.1 - 0.14 12.4 0.1 40 4.5 0.0 2.9 2 1 1 3 3 3 0 PTS HPr component phosphorylation site T2SSE PF00437.20 ACS99757.1 - 2e-33 115.6 0.2 2.8e-33 115.1 0.2 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 ACS99757.1 - 4.2e-05 24.0 0.0 0.02 15.3 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 ACS99757.1 - 0.00022 21.3 0.0 0.00064 19.7 0.0 1.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_21 PF13304.6 ACS99757.1 - 0.0038 17.1 0.0 0.0089 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 ACS99757.1 - 0.012 15.3 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 ACS99757.1 - 0.014 15.7 0.0 0.028 14.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ACS99757.1 - 0.014 15.9 0.0 0.027 15.0 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 ACS99757.1 - 0.021 14.3 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region HD_4 PF13328.6 ACS99757.1 - 0.026 14.3 0.0 0.072 12.8 0.0 1.7 2 0 0 2 2 2 0 HD domain Pox_A32 PF04665.12 ACS99757.1 - 0.036 13.5 0.0 0.056 12.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_14 PF13173.6 ACS99757.1 - 0.038 14.0 0.0 0.081 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Guanylate_kin PF00625.21 ACS99757.1 - 0.047 13.4 0.0 0.083 12.6 0.0 1.3 1 0 0 1 1 1 0 Guanylate kinase bPH_6 PF10756.9 ACS99757.1 - 0.049 13.7 1.1 1.2 9.3 0.0 3.1 3 0 0 3 3 3 0 Bacterial PH domain MMR_HSR1 PF01926.23 ACS99757.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase MobB PF03205.14 ACS99757.1 - 0.05 13.5 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.18 ACS99757.1 - 0.1 11.9 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Lon_2 PF13337.6 ACS99757.1 - 0.11 11.1 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Putative ATP-dependent Lon protease Adeno_IVa2 PF02456.15 ACS99757.1 - 0.14 10.9 0.0 0.29 9.9 0.0 1.5 1 1 0 1 1 1 0 Adenovirus IVa2 protein Pox_A28 PF04584.14 ACS99757.1 - 0.15 12.3 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A28 family AAA_24 PF13479.6 ACS99757.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ACS99757.1 - 0.16 12.2 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase T2SSF PF00482.23 ACS99758.1 - 6.3e-08 32.6 1.8 2.5e-07 30.7 0.1 2.4 2 1 0 2 2 2 1 Type II secretion system (T2SS), protein F CR6_interact PF10147.9 ACS99758.1 - 0.084 12.6 0.4 0.084 12.6 0.4 1.8 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF2530 PF10745.9 ACS99758.1 - 2.1 8.7 5.5 0.26 11.5 1.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) DUF2157 PF09925.9 ACS99758.1 - 5.7 6.7 9.4 1.7 8.5 3.3 2.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) Phage_holin_3_6 PF07332.11 ACS99759.1 - 0.71 9.9 4.5 10 6.2 3.1 2.9 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Ac76 PF05814.11 ACS99760.1 - 0.0029 17.6 0.3 0.0031 17.5 0.3 1.1 1 0 0 1 1 1 1 Orf76 (Ac76) ODV-E18 PF10717.9 ACS99760.1 - 0.051 13.5 2.9 0.058 13.3 2.9 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Peptidase_M24 PF00557.24 ACS99764.1 - 5e-38 130.9 0.0 7.3e-38 130.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 ACS99764.1 - 1.2e-12 48.6 0.0 2e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain bPH_2 PF03703.14 ACS99765.1 - 2e-13 50.4 0.1 2.8e-13 49.9 0.1 1.2 1 0 0 1 1 1 1 Bacterial PH domain 2TM PF13239.6 ACS99765.1 - 0.0053 17.0 4.0 0.0085 16.4 4.0 1.3 1 0 0 1 1 1 1 2TM domain bPH_2 PF03703.14 ACS99766.1 - 2.4e-35 120.6 1.4 8.6e-20 70.7 0.1 3.2 3 0 0 3 3 3 3 Bacterial PH domain SH3_12 PF18129.1 ACS99767.1 - 0.07 13.2 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Xrn1 SH3-like domain Glu-tRNAGln PF02686.15 ACS99768.1 - 2.5e-22 79.0 0.4 3.4e-22 78.5 0.4 1.2 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit VGPC1_C PF16799.5 ACS99768.1 - 0.047 13.7 0.2 0.072 13.1 0.2 1.3 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Amidase PF01425.21 ACS99769.1 - 7.7e-163 542.6 0.0 8.7e-163 542.5 0.0 1.0 1 0 0 1 1 1 1 Amidase GatB_N PF02934.15 ACS99770.1 - 7.8e-113 376.4 0.0 9.7e-113 376.1 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 ACS99770.1 - 1.6e-55 187.0 1.6 2.3e-55 186.5 1.6 1.2 1 0 0 1 1 1 1 GatB domain MgtC PF02308.16 ACS99771.1 - 9.9e-41 138.9 12.8 1.4e-40 138.4 12.8 1.2 1 0 0 1 1 1 1 MgtC family ERGIC_N PF13850.6 ACS99771.1 - 0.0036 17.6 0.4 0.11 12.8 0.1 2.3 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) ACT_4 PF13291.6 ACS99771.1 - 0.041 14.5 0.9 0.065 13.8 0.9 1.3 1 0 0 1 1 1 0 ACT domain DUF4097 PF13349.6 ACS99772.1 - 2.2e-11 43.6 13.7 2.9e-10 39.9 13.7 2.4 1 1 0 1 1 1 1 Putative adhesin TM2 PF05154.16 ACS99772.1 - 0.067 13.5 0.4 0.067 13.5 0.4 3.0 4 0 0 4 4 4 0 TM2 domain Oxidored_q3 PF00499.20 ACS99772.1 - 3.5 7.4 6.8 21 4.8 6.7 2.3 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 ECF_trnsprt PF12822.7 ACS99772.1 - 5.6 7.0 15.1 0.087 12.9 2.1 2.6 2 1 1 3 3 3 0 ECF transporter, substrate-specific component ABC2_membrane_3 PF12698.7 ACS99772.1 - 8.3 5.4 9.2 19 4.2 9.3 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein FUR PF01475.19 ACS99773.1 - 1.4e-35 122.1 0.0 1.8e-35 121.7 0.0 1.1 1 0 0 1 1 1 1 Ferric uptake regulator family HTH_20 PF12840.7 ACS99773.1 - 0.016 15.3 0.0 0.043 13.9 0.0 1.8 1 1 0 1 1 1 0 Helix-turn-helix domain SR1P PF13790.6 ACS99773.1 - 0.045 13.9 0.2 12 6.1 0.0 2.8 3 0 0 3 3 3 0 SR1 protein zf-CSL PF05207.13 ACS99773.1 - 0.06 13.1 0.4 0.11 12.2 0.4 1.4 1 1 0 1 1 1 0 CSL zinc finger Cytochrom_C550 PF14495.6 ACS99773.1 - 0.16 11.7 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c-550 domain Glyco_hydro_18 PF00704.28 ACS99774.1 - 3.7e-29 102.5 0.7 3.7e-29 102.5 0.7 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 Cu_amine_oxidN1 PF07833.11 ACS99774.1 - 2.1e-09 37.7 0.2 6.3e-09 36.2 0.0 2.0 2 0 0 2 2 2 1 Copper amine oxidase N-terminal domain Glyco_hydro_85 PF03644.13 ACS99774.1 - 0.00019 20.9 0.1 0.00029 20.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 SH3_3 PF08239.11 ACS99774.1 - 0.003 17.8 0.6 0.0058 16.9 0.0 1.8 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_4 PF06347.13 ACS99774.1 - 0.08 12.8 0.0 0.24 11.3 0.0 1.9 1 0 0 1 1 1 0 Bacterial SH3 domain DUF2614 PF11023.8 ACS99775.1 - 4.7e-29 100.7 1.0 5.8e-29 100.4 1.0 1.0 1 0 0 1 1 1 1 Zinc-ribbon containing domain PHO4 PF01384.20 ACS99775.1 - 0.021 13.9 2.2 0.023 13.8 2.2 1.0 1 0 0 1 1 1 0 Phosphate transporter family DZR PF12773.7 ACS99775.1 - 0.022 14.8 0.9 0.033 14.2 0.9 1.3 1 0 0 1 1 1 0 Double zinc ribbon Cytochrome_C7 PF14522.6 ACS99775.1 - 0.081 12.9 0.5 0.12 12.4 0.5 1.2 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c DUF2207 PF09972.9 ACS99775.1 - 0.33 9.7 8.3 0.4 9.4 8.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF202 PF02656.15 ACS99775.1 - 1.5 9.3 9.4 5.5 7.5 9.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF2721 PF11026.8 ACS99775.1 - 1.5 8.7 8.6 6.5 6.7 8.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) NTF-like PF14540.6 ACS99776.1 - 4.8e-30 103.8 0.0 7.9e-30 103.0 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase-like HTH_52 PF18576.1 ACS99776.1 - 8.1e-07 29.2 0.0 2.2e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain GerA PF03323.13 ACS99777.1 - 1e-188 627.6 7.6 1.2e-188 627.4 7.6 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_GerAC PF05504.11 ACS99778.1 - 6.8e-39 133.7 0.6 1.1e-38 133.1 0.6 1.3 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal PseudoU_synth_1 PF01416.20 ACS99778.1 - 0.05 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 tRNA pseudouridine synthase Spore_permease PF03845.13 ACS99780.1 - 4.7e-61 206.4 37.0 6.7e-61 205.9 37.0 1.2 1 0 0 1 1 1 1 Spore germination protein FUSC_2 PF13515.6 ACS99781.1 - 1.9 8.6 14.4 0.19 11.8 5.4 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein-like Promethin PF16015.5 ACS99781.1 - 6 6.9 14.3 3.7 7.5 2.0 2.1 2 0 0 2 2 2 0 Promethin PspA_IM30 PF04012.12 ACS99782.1 - 1e-26 93.9 21.7 1.3e-26 93.6 21.7 1.0 1 0 0 1 1 1 1 PspA/IM30 family PRKG1_interact PF15898.5 ACS99782.1 - 0.023 15.6 8.9 0.023 15.6 8.9 3.8 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF702 PF05142.12 ACS99782.1 - 0.041 14.4 1.0 0.064 13.7 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF702) CDH1_2_SANT_HL1 PF18375.1 ACS99782.1 - 0.049 14.3 0.0 0.049 14.3 0.0 2.7 2 1 1 3 3 3 0 CDH1/2 SANT-Helical linker 1 DUF148 PF02520.17 ACS99782.1 - 0.2 11.8 10.1 0.059 13.5 5.6 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF148 RIBIOP_C PF04950.12 ACS99782.1 - 3.5 7.0 7.0 0.17 11.2 1.5 1.7 2 0 0 2 2 2 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal PspC PF04024.12 ACS99783.1 - 3.1e-17 62.1 0.5 4.3e-17 61.7 0.5 1.2 1 0 0 1 1 1 1 PspC domain HALZ PF02183.18 ACS99783.1 - 0.054 13.7 0.4 0.086 13.1 0.4 1.3 1 0 0 1 1 1 0 Homeobox associated leucine zipper COX7C PF02935.16 ACS99783.1 - 0.13 12.5 0.4 0.32 11.3 0.4 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc Keratin_2_head PF16208.5 ACS99783.1 - 1.8 8.7 19.2 2.7 8.1 19.2 1.2 1 0 0 1 1 1 0 Keratin type II head PspA_IM30 PF04012.12 ACS99784.1 - 2.2e-47 161.5 23.1 2.9e-47 161.1 23.1 1.2 1 0 0 1 1 1 1 PspA/IM30 family DUF724 PF05266.14 ACS99784.1 - 0.00027 20.8 13.5 0.058 13.2 0.2 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF724) DUF2935 PF11155.8 ACS99784.1 - 0.004 17.5 1.5 0.004 17.5 1.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF2935) FAM184 PF15665.5 ACS99784.1 - 0.035 13.9 17.5 0.064 13.0 17.5 1.4 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B DUF948 PF06103.11 ACS99784.1 - 0.42 10.9 5.2 2.6 8.4 0.3 3.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) PRKG1_interact PF15898.5 ACS99784.1 - 0.99 10.3 22.6 6 7.8 11.5 3.7 2 2 0 2 2 2 0 cGMP-dependent protein kinase interacting domain LIN52 PF10044.9 ACS99784.1 - 1 10.1 5.0 0.72 10.6 0.9 2.4 1 1 0 2 2 2 0 Retinal tissue protein MBF1 PF08523.10 ACS99784.1 - 1.9 9.0 7.3 12 6.4 0.1 3.3 3 0 0 3 3 3 0 Multiprotein bridging factor 1 Fib_alpha PF08702.10 ACS99784.1 - 2.5 8.3 16.5 0.11 12.7 2.1 2.9 2 1 0 3 3 3 0 Fibrinogen alpha/beta chain family AAA_23 PF13476.6 ACS99784.1 - 2.5 8.6 13.4 6.6 7.2 9.7 2.2 2 0 0 2 2 2 0 AAA domain DUF2924 PF11149.8 ACS99784.1 - 3.4 8.1 9.3 1.1 9.6 2.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2924) DUF2570 PF10828.8 ACS99784.1 - 5.4 6.9 10.9 14 5.6 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) Exonuc_VII_L PF02601.15 ACS99784.1 - 7.2 6.1 14.7 12 5.4 14.7 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit IZUMO PF15005.6 ACS99784.1 - 7.4 7.1 7.2 11 6.6 5.9 2.0 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated PhoU PF01895.19 ACS99784.1 - 9.5 6.8 13.5 3.1 8.3 3.3 3.2 1 1 2 3 3 3 0 PhoU domain HisKA_3 PF07730.13 ACS99785.1 - 1.2e-18 67.4 7.1 1.2e-18 67.4 7.1 2.0 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACS99785.1 - 1.6e-07 31.8 0.0 5.9e-07 30.0 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACS99785.1 - 0.00098 19.1 0.0 0.0024 17.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain RskA PF10099.9 ACS99785.1 - 0.014 15.7 3.0 0.071 13.4 3.0 2.1 1 1 0 1 1 1 0 Anti-sigma-K factor rskA DUF2721 PF11026.8 ACS99785.1 - 0.019 14.9 0.6 0.077 12.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF3852 PF12963.7 ACS99785.1 - 0.023 15.0 2.1 6.2 7.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3852) Tetraspanin PF00335.20 ACS99785.1 - 0.025 14.3 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 Tetraspanin family GTSE1_N PF15259.6 ACS99785.1 - 0.035 14.3 4.3 1.4 9.1 2.7 2.4 2 1 0 2 2 2 0 G-2 and S-phase expressed 1 Response_reg PF00072.24 ACS99786.1 - 2.3e-26 92.1 0.2 4.6e-26 91.2 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 ACS99786.1 - 3.2e-22 77.8 0.0 7.7e-22 76.6 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACS99786.1 - 5.2e-05 22.8 0.0 0.00016 21.3 0.0 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACS99786.1 - 0.0022 17.5 0.1 0.0073 15.8 0.0 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_23 PF13384.6 ACS99786.1 - 0.0027 17.5 0.0 0.021 14.6 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_7 PF02796.15 ACS99786.1 - 0.035 14.2 0.0 0.094 12.8 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_40 PF14493.6 ACS99786.1 - 0.045 14.2 0.1 1.4 9.4 0.0 2.5 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.6 ACS99786.1 - 0.061 12.9 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF1754 PF08555.10 ACS99788.1 - 0.0027 18.5 0.3 0.0034 18.2 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) DUF1779 PF08680.10 ACS99789.1 - 4.5e-12 46.6 0.4 9.1e-12 45.6 0.4 1.5 1 1 0 1 1 1 1 TATA-box binding SOXp PF12336.8 ACS99789.1 - 0.073 14.1 0.2 0.14 13.2 0.2 1.4 1 0 0 1 1 1 0 SOX transcription factor G6PD_C PF02781.16 ACS99790.1 - 5.5e-120 399.9 0.0 7.1e-120 399.6 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ACS99790.1 - 5.7e-63 212.7 0.0 8.9e-63 212.1 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Cyclase PF04199.13 ACS99791.1 - 2e-26 92.8 0.0 2.5e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Putative cyclase GTP_EFTU PF00009.27 ACS99792.1 - 5.8e-49 166.3 0.0 8.6e-49 165.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RF3_C PF16658.5 ACS99792.1 - 9.6e-44 148.4 0.1 1.9e-43 147.4 0.1 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 ACS99792.1 - 1.8e-06 28.0 0.0 4.4e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 ACS99792.1 - 0.00021 21.6 0.0 0.00045 20.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ACS99792.1 - 0.00021 21.3 0.0 0.00049 20.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II FeoB_N PF02421.18 ACS99792.1 - 0.013 15.0 0.0 0.27 10.7 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B TM2 PF05154.16 ACS99793.1 - 1.5e-12 47.6 0.4 1.5e-12 47.6 0.4 2.1 2 0 0 2 2 2 1 TM2 domain Lung_7-TM_R PF06814.13 ACS99793.1 - 0.002 17.4 1.5 0.0022 17.3 1.5 1.0 1 0 0 1 1 1 1 Lung seven transmembrane receptor Mem_trans PF03547.18 ACS99793.1 - 0.039 12.4 2.4 0.046 12.1 2.4 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF2207 PF09972.9 ACS99793.1 - 0.14 10.8 1.5 0.15 10.8 1.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1418 PF07214.12 ACS99793.1 - 0.17 11.8 1.6 0.15 11.9 0.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) DUF3043 PF11241.8 ACS99793.1 - 0.39 10.7 1.5 0.61 10.1 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) TM2 PF05154.16 ACS99794.1 - 4.6e-19 68.5 6.9 6.6e-19 68.0 6.9 1.2 1 0 0 1 1 1 1 TM2 domain DUF997 PF06196.12 ACS99794.1 - 0.11 12.5 2.1 0.36 10.9 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF997) GFO_IDH_MocA PF01408.22 ACS99795.1 - 1.7e-24 86.9 0.0 2.9e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACS99795.1 - 5e-11 42.6 0.0 2.5e-10 40.4 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACS99795.1 - 0.00012 22.7 0.0 0.00018 22.1 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ThuA PF06283.11 ACS99796.1 - 4.6e-43 147.9 0.2 5.3e-43 147.7 0.2 1.0 1 0 0 1 1 1 1 Trehalose utilisation GFO_IDH_MocA PF01408.22 ACS99797.1 - 8.4e-22 78.3 0.1 1.5e-21 77.5 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold 2-Hacid_dh_C PF02826.19 ACS99797.1 - 0.0041 16.5 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 ACS99797.1 - 0.0045 17.6 0.2 0.0073 16.9 0.2 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain CoA_binding PF02629.19 ACS99797.1 - 0.0062 17.2 0.1 0.02 15.6 0.1 1.8 1 0 0 1 1 1 1 CoA binding domain F420_oxidored PF03807.17 ACS99797.1 - 0.0091 16.6 0.1 0.017 15.7 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 ACS99797.1 - 0.051 13.8 0.2 0.14 12.4 0.2 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Amidohydro_1 PF01979.20 ACS99798.1 - 3.3e-14 53.0 0.2 6.8e-12 45.4 0.0 3.1 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_3 PF07969.11 ACS99798.1 - 2.8e-12 46.9 0.0 4e-07 29.9 0.1 2.4 3 0 0 3 3 3 2 Amidohydrolase family SSPI PF14098.6 ACS99799.1 - 2.5e-26 91.6 0.9 2.8e-26 91.4 0.9 1.0 1 0 0 1 1 1 1 Small, acid-soluble spore protein I Catalase-rel PF06628.12 ACS99799.1 - 0.085 13.1 0.1 3 8.1 0.0 2.1 2 0 0 2 2 2 0 Catalase-related immune-responsive TrkA_N PF02254.18 ACS99800.1 - 9.4e-30 103.2 1.7 1.6e-29 102.5 1.2 1.7 2 0 0 2 2 1 1 TrkA-N domain TrkA_C PF02080.21 ACS99800.1 - 3.6e-12 45.9 0.2 9.1e-11 41.4 0.0 2.6 3 0 0 3 3 2 1 TrkA-C domain NAD_binding_2 PF03446.15 ACS99800.1 - 2.1e-07 31.3 0.5 3.5e-07 30.5 0.5 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 ACS99800.1 - 1.8e-06 27.9 0.1 4.3e-06 26.7 0.1 1.7 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 ACS99800.1 - 6.4e-06 26.2 0.7 0.015 15.3 0.1 2.5 1 1 1 2 2 2 2 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ACS99800.1 - 6.9e-06 25.5 0.1 1.8e-05 24.2 0.0 1.8 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ACS99800.1 - 2.3e-05 24.9 0.5 6.4e-05 23.5 0.5 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 ACS99800.1 - 0.00076 19.5 0.0 0.0016 18.4 0.0 1.7 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus IlvN PF07991.12 ACS99800.1 - 0.001 18.7 0.9 0.0027 17.3 0.4 1.9 1 1 1 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.14 ACS99800.1 - 0.0016 18.1 0.0 0.0029 17.2 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 ACS99800.1 - 0.0018 18.5 0.3 0.003 17.8 0.3 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ACS99800.1 - 0.0024 18.0 0.1 0.0053 16.8 0.1 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 ACS99800.1 - 0.0028 17.2 0.1 0.0039 16.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family UPF0146 PF03686.13 ACS99800.1 - 0.0034 17.2 2.2 0.071 13.0 0.4 3.0 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0146) CoA_binding_2 PF13380.6 ACS99800.1 - 0.0038 17.7 0.1 0.0092 16.5 0.1 1.7 1 1 1 2 2 2 1 CoA binding domain adh_short PF00106.25 ACS99800.1 - 0.0041 16.6 0.1 0.02 14.3 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase ApbA PF02558.16 ACS99800.1 - 0.0049 16.5 0.1 0.0082 15.8 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 ACS99800.1 - 0.0098 15.2 1.0 0.025 13.9 0.9 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain XdhC_C PF13478.6 ACS99800.1 - 0.011 16.2 0.0 0.047 14.2 0.0 1.9 1 1 1 2 2 2 0 XdhC Rossmann domain Acetyltransf_18 PF18014.1 ACS99800.1 - 0.02 14.7 0.2 3.9 7.3 0.0 2.2 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain PglD_N PF17836.1 ACS99800.1 - 0.021 15.5 0.4 0.08 13.6 0.1 2.0 2 0 0 2 2 2 0 PglD N-terminal domain NAD_binding_7 PF13241.6 ACS99800.1 - 0.023 15.1 0.4 0.049 14.1 0.2 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding GFO_IDH_MocA PF01408.22 ACS99800.1 - 0.072 13.9 0.1 0.13 13.0 0.1 1.5 1 1 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold ThiF PF00899.21 ACS99800.1 - 0.079 12.3 0.8 0.84 8.9 0.1 2.1 1 1 1 2 2 2 0 ThiF family NAD_binding_8 PF13450.6 ACS99800.1 - 0.14 12.4 0.0 0.57 10.5 0.0 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 ACS99800.1 - 0.16 12.6 1.8 4.5 7.9 0.1 3.1 2 1 2 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase SpoU_methylase PF00588.19 ACS99801.1 - 1.2e-39 135.7 0.0 2e-39 135.0 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 ACS99801.1 - 5.9e-06 26.5 0.1 1.8e-05 24.9 0.0 1.8 2 0 0 2 2 2 1 RNA 2'-O ribose methyltransferase substrate binding Glyco_hydro_43 PF04616.14 ACS99802.1 - 2.1e-45 155.3 13.3 2.1e-45 155.3 13.3 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 43 SLH PF00395.20 ACS99802.1 - 7.2e-19 67.5 0.3 1.7e-08 34.4 0.0 3.9 3 0 0 3 3 3 2 S-layer homology domain Big_2 PF02368.18 ACS99802.1 - 4.5e-14 52.1 17.8 4.1e-13 49.0 8.4 6.6 6 1 1 7 7 7 3 Bacterial Ig-like domain (group 2) Glyco_hydro_115 PF15979.5 ACS99803.1 - 2.6e-108 362.5 5.0 4e-108 361.9 5.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 ACS99803.1 - 9.2e-43 146.0 1.9 2.3e-37 128.4 0.0 4.0 3 1 0 3 3 3 2 Gylcosyl hydrolase family 115 C-terminal domain SLH PF00395.20 ACS99803.1 - 1.7e-19 69.6 0.6 2.8e-09 36.9 0.0 4.3 3 0 0 3 3 3 2 S-layer homology domain Big_2 PF02368.18 ACS99803.1 - 1.2e-12 47.6 8.2 1.2e-12 47.6 8.2 5.1 6 0 0 6 6 6 1 Bacterial Ig-like domain (group 2) Glyco_hydro_67N PF03648.14 ACS99803.1 - 2.3e-06 27.9 0.0 6.6e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus Glyco_hydro_20b PF02838.15 ACS99803.1 - 0.3 11.9 0.1 0.3 11.9 0.1 3.3 4 0 0 4 4 4 0 Glycosyl hydrolase family 20, domain 2 DUF2341 PF10102.9 ACS99803.1 - 7.6 7.2 7.6 1.7e+02 2.9 0.5 5.3 4 1 0 4 4 4 0 Domain of unknown function (DUF2341) SASP PF00269.20 ACS99804.1 - 5.1e-27 93.7 0.2 5.9e-27 93.5 0.2 1.1 1 0 0 1 1 1 1 Small, acid-soluble spore proteins, alpha/beta type DNA_ligase_A_M PF01068.21 ACS99805.1 - 1.6e-32 112.8 0.1 2.4e-32 112.3 0.1 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 ACS99805.1 - 1.4e-05 25.5 0.3 2.1e-05 24.9 0.3 1.3 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 ACS99805.1 - 0.01 15.7 0.1 0.042 13.7 0.0 2.0 2 1 0 2 2 2 0 mRNA capping enzyme, catalytic domain DNA_ligase_A_C PF04679.15 ACS99805.1 - 0.045 14.4 0.0 0.099 13.3 0.0 1.6 1 0 0 1 1 1 0 ATP dependent DNA ligase C terminal region PspA_IM30 PF04012.12 ACS99806.1 - 6.8e-14 52.0 15.9 8e-14 51.8 15.9 1.0 1 0 0 1 1 1 1 PspA/IM30 family CCDC53 PF10152.9 ACS99806.1 - 0.00026 21.5 5.7 0.00071 20.0 4.1 1.9 1 1 1 2 2 2 1 Subunit CCDC53 of WASH complex Myc-LZ PF02344.15 ACS99806.1 - 0.0014 18.7 3.0 0.0019 18.2 0.6 2.5 2 0 0 2 2 2 1 Myc leucine zipper domain Fungal_TACC PF12709.7 ACS99806.1 - 0.0028 18.0 5.8 0.042 14.3 1.6 2.5 2 0 0 2 2 2 1 Fungal Transforming acidic coiled-coil (TACC) proteins bZIP_2 PF07716.15 ACS99806.1 - 0.0068 16.5 2.5 0.025 14.7 2.5 2.0 1 0 0 1 1 1 1 Basic region leucine zipper DUF4407 PF14362.6 ACS99806.1 - 0.027 13.9 6.3 0.032 13.6 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ADIP PF11559.8 ACS99806.1 - 0.032 14.3 7.2 0.032 14.3 7.2 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ZapB PF06005.12 ACS99806.1 - 0.043 14.3 5.9 0.043 14.3 5.9 2.7 1 1 2 3 3 3 0 Cell division protein ZapB DUF4806 PF16064.5 ACS99806.1 - 0.052 13.9 1.5 0.1 12.9 0.3 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4806) bZIP_1 PF00170.21 ACS99806.1 - 0.055 13.6 2.8 0.055 13.6 2.8 2.2 2 1 0 2 2 2 0 bZIP transcription factor MOSC_N PF03476.16 ACS99806.1 - 0.058 13.3 0.5 0.095 12.6 0.4 1.4 1 1 0 1 1 1 0 MOSC N-terminal beta barrel domain Crl PF07417.12 ACS99806.1 - 0.074 13.1 1.4 0.29 11.2 0.8 2.1 2 0 0 2 2 2 0 Sigma factor-binding transcriptional regulator Crl FSH1 PF03959.13 ACS99806.1 - 0.11 12.2 1.2 0.14 11.8 1.2 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF4094 PF13334.6 ACS99806.1 - 0.11 12.9 2.7 0.22 11.9 2.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) RasGAP_C PF03836.15 ACS99806.1 - 0.31 11.2 7.6 0.13 12.4 3.5 2.0 2 0 0 2 2 2 0 RasGAP C-terminus DUF1664 PF07889.12 ACS99806.1 - 0.38 10.8 3.4 0.21 11.6 1.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CLZ PF16526.5 ACS99806.1 - 0.56 10.6 8.5 0.25 11.7 5.1 2.3 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF3510 PF12022.8 ACS99806.1 - 0.57 10.6 7.8 0.11 12.9 0.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) Spc24 PF08286.11 ACS99806.1 - 1.4 9.2 11.0 0.36 11.1 4.1 2.4 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 CENP-Q PF13094.6 ACS99806.1 - 1.6 8.9 15.7 0.6 10.3 12.0 1.8 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit OEP PF02321.18 ACS99806.1 - 1.6 8.5 16.7 0.57 10.0 11.6 2.0 1 1 1 2 2 2 0 Outer membrane efflux protein Exonuc_VII_L PF02601.15 ACS99806.1 - 2.2 7.8 8.9 2.9 7.4 8.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0449 PF15136.6 ACS99806.1 - 4.5 7.8 9.4 1.8 9.1 4.8 2.2 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 APG6_N PF17675.1 ACS99806.1 - 5.3 7.6 18.2 8.2 7.0 17.4 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region FapA PF03961.13 ACS99806.1 - 5.6 5.5 6.4 7.6 5.0 6.2 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A GrpE PF01025.19 ACS99806.1 - 9.1 5.9 11.9 3.6 7.2 4.8 2.3 1 1 0 2 2 2 0 GrpE HrpE PF06188.12 ACS99807.1 - 0.1 12.4 0.5 0.68 9.8 0.1 2.2 1 1 1 2 2 2 0 HrpE/YscL/FliH and V-type ATPase subunit E E1-E2_ATPase PF00122.20 ACS99808.1 - 4.3e-52 176.2 0.1 4.3e-52 176.2 0.1 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ACS99808.1 - 1.3e-40 140.0 0.5 2.1e-40 139.3 0.5 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ACS99808.1 - 2.6e-07 31.0 0.0 7.1e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 ACS99808.1 - 5.1e-05 23.1 0.5 5.1e-05 23.1 0.5 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ACS99808.1 - 0.096 13.1 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase UreE_C PF05194.12 ACS99808.1 - 0.25 11.9 9.1 0.58 10.7 9.1 1.6 1 0 0 1 1 1 0 UreE urease accessory protein, C-terminal domain SelP_N PF04592.14 ACS99808.1 - 0.71 9.2 7.3 1.1 8.6 7.3 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CopD PF05425.13 ACS99809.1 - 1.2e-09 38.5 4.2 1.2e-09 38.5 4.2 3.2 3 1 0 3 3 3 1 Copper resistance protein D HTH_5 PF01022.20 ACS99810.1 - 1.6e-17 63.1 0.8 3.3e-17 62.1 0.8 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACS99810.1 - 1.8e-09 37.5 0.1 2.9e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 ACS99810.1 - 0.00069 19.4 0.2 0.0014 18.5 0.2 1.5 1 1 0 1 1 1 1 MarR family TrmB PF01978.19 ACS99810.1 - 0.012 15.5 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HxlR PF01638.17 ACS99810.1 - 0.014 15.2 0.2 0.021 14.7 0.2 1.4 1 1 0 1 1 1 0 HxlR-like helix-turn-helix HTH_27 PF13463.6 ACS99810.1 - 0.024 15.1 0.1 0.039 14.5 0.1 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_1 PF00126.27 ACS99810.1 - 0.033 14.1 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_24 PF13412.6 ACS99810.1 - 0.038 13.5 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Pyr_redox_2 PF07992.14 ACS99811.1 - 4.5e-52 177.1 0.2 5.3e-52 176.9 0.2 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACS99811.1 - 4.9e-25 88.4 0.1 9.4e-19 67.8 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACS99811.1 - 1.4e-18 67.2 0.9 3.5e-16 59.5 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACS99811.1 - 5.4e-07 29.5 3.6 0.0096 15.5 0.3 2.8 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ACS99811.1 - 3.5e-06 26.4 5.6 0.0015 17.7 0.1 3.6 2 1 2 4 4 4 2 FAD binding domain NAD_binding_8 PF13450.6 ACS99811.1 - 3.6e-06 27.1 0.0 3e-05 24.2 0.0 2.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ACS99811.1 - 3.7e-06 25.9 0.1 0.0084 14.8 0.1 3.6 3 1 1 4 4 4 2 HI0933-like protein K_oxygenase PF13434.6 ACS99811.1 - 5.7e-06 25.7 0.3 0.062 12.4 0.0 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 ACS99811.1 - 1.2e-05 25.3 0.5 0.076 13.0 0.0 3.2 3 1 0 3 3 3 2 FAD-NAD(P)-binding GIDA PF01134.22 ACS99811.1 - 2.4e-05 23.6 0.4 0.087 11.9 0.0 3.3 3 1 0 3 3 3 2 Glucose inhibited division protein A Thi4 PF01946.17 ACS99811.1 - 0.00015 21.1 0.0 0.00084 18.6 0.0 2.2 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 ACS99811.1 - 0.00025 20.4 0.0 0.032 13.5 0.0 2.4 3 0 0 3 3 3 1 FAD binding domain FAD_oxidored PF12831.7 ACS99811.1 - 0.00059 19.3 0.7 0.016 14.6 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ACS99811.1 - 0.00083 18.5 0.1 1.3 8.0 0.1 2.8 4 0 0 4 4 4 2 Lycopene cyclase protein NAD_binding_7 PF13241.6 ACS99811.1 - 0.0011 19.3 0.0 0.0069 16.8 0.0 2.0 2 0 0 2 2 2 1 Putative NAD(P)-binding Trp_halogenase PF04820.14 ACS99811.1 - 0.0038 16.1 0.1 0.83 8.4 0.1 2.8 3 0 0 3 3 3 1 Tryptophan halogenase Amino_oxidase PF01593.24 ACS99811.1 - 0.019 14.2 0.1 4.9 6.3 0.0 2.1 1 1 0 2 2 2 0 Flavin containing amine oxidoreductase Shikimate_DH PF01488.20 ACS99811.1 - 0.044 13.8 0.4 0.76 9.8 0.0 2.6 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase AhpC-TSA PF00578.21 ACS99812.1 - 7.2e-20 71.1 0.0 8.7e-20 70.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ACS99812.1 - 5e-18 65.2 0.0 5.9e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 Redoxin MarR PF01047.22 ACS99813.1 - 1.5e-18 66.4 0.1 2.9e-18 65.5 0.1 1.5 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACS99813.1 - 1.3e-12 47.4 0.1 3.4e-12 46.1 0.1 1.7 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 ACS99813.1 - 4.2e-11 43.2 0.2 6.1e-11 42.7 0.2 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.19 ACS99813.1 - 1.2e-06 28.3 0.1 3.5e-06 26.8 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 ACS99813.1 - 1.8e-05 24.7 0.3 0.00017 21.6 0.3 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.6 ACS99813.1 - 5.9e-05 22.6 0.0 0.00025 20.5 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding FeoC PF09012.10 ACS99813.1 - 0.00025 21.1 0.1 0.00044 20.3 0.1 1.4 1 0 0 1 1 1 1 FeoC like transcriptional regulator Fe_dep_repress PF01325.19 ACS99813.1 - 0.0003 20.9 0.1 0.00055 20.1 0.1 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain TFIIE_alpha PF02002.17 ACS99813.1 - 0.00039 20.2 0.1 0.00099 18.9 0.1 1.6 2 0 0 2 2 2 1 TFIIE alpha subunit HTH_34 PF13601.6 ACS99813.1 - 0.00043 20.4 0.0 0.00061 19.9 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain PadR PF03551.14 ACS99813.1 - 0.0013 18.6 0.0 0.0044 16.9 0.0 1.7 2 0 0 2 2 2 1 Transcriptional regulator PadR-like family HTH_5 PF01022.20 ACS99813.1 - 0.0018 18.1 0.1 0.005 16.7 0.0 1.8 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family Penicillinase_R PF03965.16 ACS99813.1 - 0.0029 17.9 0.1 0.0069 16.7 0.1 1.6 2 0 0 2 2 2 1 Penicillinase repressor HTH_IclR PF09339.10 ACS99813.1 - 0.0053 16.5 0.3 0.0089 15.8 0.3 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain DprA_WH PF17782.1 ACS99813.1 - 0.011 15.8 0.2 0.019 15.1 0.2 1.4 1 0 0 1 1 1 0 DprA winged helix domain HxlR PF01638.17 ACS99813.1 - 0.019 14.8 0.1 0.029 14.2 0.1 1.2 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Rrf2 PF02082.20 ACS99813.1 - 0.057 13.8 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator Aldo_ket_red PF00248.21 ACS99814.1 - 8e-48 163.1 0.5 5.6e-46 157.1 0.5 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family AraC_N PF06719.13 ACS99815.1 - 1.9e-49 167.2 0.0 3.3e-49 166.4 0.0 1.4 1 0 0 1 1 1 1 AraC-type transcriptional regulator N-terminus HTH_18 PF12833.7 ACS99815.1 - 1.8e-22 79.4 0.3 3.5e-22 78.5 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99815.1 - 9.5e-13 47.9 0.2 3.4e-08 33.4 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF3539 PF12058.8 ACS99815.1 - 0.039 14.1 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3539) TetR_N PF00440.23 ACS99815.1 - 0.04 13.7 0.0 0.098 12.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_24 PF13412.6 ACS99815.1 - 0.04 13.5 0.0 0.12 11.9 0.0 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MFS_1 PF07690.16 ACS99816.1 - 5e-45 154.0 49.3 1.4e-31 109.7 23.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ACS99816.1 - 6.8e-15 54.8 22.0 1.6e-14 53.6 21.8 1.6 1 1 0 1 1 1 1 MFS_1 like family AAA_33 PF13671.6 ACS99817.1 - 3.8e-16 59.5 0.0 6.9e-16 58.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ACS99817.1 - 2.9e-06 27.8 0.5 2.2e-05 25.0 0.4 2.1 1 1 0 1 1 1 1 AAA domain CPT PF07931.12 ACS99817.1 - 2.4e-05 24.2 0.7 0.002 18.0 0.7 2.1 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein KTI12 PF08433.10 ACS99817.1 - 6.2e-05 22.6 0.2 0.00041 19.9 0.2 1.9 1 1 0 1 1 1 1 Chromatin associated protein KTI12 APS_kinase PF01583.20 ACS99817.1 - 0.00029 20.8 0.2 0.0033 17.3 0.2 2.2 1 1 0 1 1 1 1 Adenylylsulphate kinase AAA PF00004.29 ACS99817.1 - 0.00031 21.2 0.1 0.0005 20.5 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ACS99817.1 - 0.00062 19.1 0.2 0.0029 16.9 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin MobB PF03205.14 ACS99817.1 - 0.0034 17.3 0.0 0.0049 16.8 0.0 1.3 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.6 ACS99817.1 - 0.0043 17.3 1.1 0.012 15.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 ACS99817.1 - 0.0073 16.7 0.3 0.014 15.9 0.3 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACS99817.1 - 0.0074 16.6 0.2 0.12 12.7 0.2 2.2 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 ACS99817.1 - 0.0088 16.1 0.0 0.0088 16.1 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain RuvB_N PF05496.12 ACS99817.1 - 0.018 14.8 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain SKI PF01202.22 ACS99817.1 - 0.026 14.6 0.3 0.27 11.3 0.0 2.2 2 1 0 2 2 2 0 Shikimate kinase Hydin_ADK PF17213.3 ACS99817.1 - 0.026 14.8 0.0 0.031 14.5 0.0 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain MeaB PF03308.16 ACS99817.1 - 0.032 13.2 0.0 0.053 12.5 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Cytidylate_kin2 PF13189.6 ACS99817.1 - 0.032 14.4 0.1 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase-like family 6PF2K PF01591.18 ACS99817.1 - 0.034 13.5 0.0 1.4 8.2 0.0 2.1 2 0 0 2 2 2 0 6-phosphofructo-2-kinase AAA_3 PF07726.11 ACS99817.1 - 0.052 13.4 0.0 0.15 11.9 0.0 1.7 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 ACS99817.1 - 0.056 13.0 0.0 0.099 12.2 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 ACS99817.1 - 0.067 12.9 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.22 ACS99817.1 - 0.075 12.2 0.1 0.41 9.8 0.0 2.1 2 1 1 3 3 3 0 NB-ARC domain ResIII PF04851.15 ACS99817.1 - 0.082 12.9 0.2 0.42 10.6 0.2 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_16 PF13191.6 ACS99817.1 - 0.11 12.9 0.1 0.11 12.9 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ACS99817.1 - 0.14 12.6 0.2 0.23 12.0 0.2 1.7 1 1 0 1 1 1 0 ABC transporter SRP54 PF00448.22 ACS99817.1 - 0.18 11.4 0.0 0.57 9.8 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF2935 PF11155.8 ACS99818.1 - 1.2e-63 212.9 0.4 1.1e-30 106.4 0.1 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF2935) Tau95 PF09734.9 ACS99819.1 - 0.009 16.8 0.4 0.39 11.5 0.1 2.1 1 1 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Baculo_p24 PF05073.12 ACS99819.1 - 0.02 14.7 0.5 0.039 13.8 0.5 1.4 1 0 0 1 1 1 0 Baculovirus P24 capsid protein NEXCaM_BD PF16644.5 ACS99819.1 - 0.15 12.3 0.2 3 8.1 0.1 2.3 2 1 0 2 2 2 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin SLH PF00395.20 ACS99820.1 - 7.1e-13 48.3 5.5 1e-06 28.6 0.1 3.5 3 1 0 3 3 3 3 S-layer homology domain TetR_N PF00440.23 ACS99821.1 - 2.2e-12 46.6 0.0 3.9e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Ubiq_cyt_C_chap PF03981.12 ACS99821.1 - 0.061 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone Las1 PF04031.13 ACS99821.1 - 0.062 13.4 0.2 0.16 12.1 0.2 1.7 1 1 0 1 1 1 0 Las1-like Pyr_redox_2 PF07992.14 ACS99822.1 - 2.1e-63 214.3 1.6 2.9e-63 213.9 1.6 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ACS99822.1 - 1.3e-31 109.1 0.3 3.1e-31 107.9 0.3 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ACS99822.1 - 7.7e-17 61.6 9.6 3e-16 59.8 0.2 3.2 4 0 0 4 4 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ACS99822.1 - 1.1e-08 34.9 4.2 1.6e-08 34.4 0.4 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 ACS99822.1 - 1e-07 31.4 9.5 1.1e-05 24.7 4.1 3.1 2 1 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ACS99822.1 - 2.9e-06 26.6 1.1 2.9e-06 26.6 1.1 3.2 3 2 1 4 4 4 1 FAD binding domain Pyr_redox_3 PF13738.6 ACS99822.1 - 1.4e-05 24.5 7.5 0.022 14.1 1.4 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ACS99822.1 - 0.0001 21.7 9.1 0.0092 15.3 0.4 3.3 2 1 1 3 3 3 2 FAD binding domain Thi4 PF01946.17 ACS99822.1 - 0.00083 18.7 2.1 0.0082 15.4 0.2 2.5 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 ACS99822.1 - 0.00099 19.3 2.8 0.066 13.4 0.2 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ACS99822.1 - 0.0046 16.1 4.9 0.5 9.3 0.5 2.8 2 1 1 3 3 3 2 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 ACS99822.1 - 0.0053 16.1 9.5 0.69 9.2 0.3 3.7 3 1 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 ACS99822.1 - 0.074 12.6 2.7 0.08 12.5 0.2 2.2 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HI0933_like PF03486.14 ACS99822.1 - 0.076 11.7 9.4 0.079 11.6 1.1 3.0 3 1 1 4 4 4 0 HI0933-like protein 2-Hacid_dh_C PF02826.19 ACS99822.1 - 0.11 11.8 2.5 7.2 5.9 0.1 2.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ACS99822.1 - 0.14 12.1 1.6 0.83 9.5 0.3 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.24 ACS99822.1 - 0.23 11.0 17.0 0.94 9.0 2.2 4.1 2 2 2 4 4 4 0 FAD dependent oxidoreductase Aldo_ket_red PF00248.21 ACS99823.1 - 1.5e-56 191.7 0.0 1.8e-56 191.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_18 PF12833.7 ACS99824.1 - 2.8e-19 69.2 0.0 4.3e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99824.1 - 1e-13 51.0 0.5 8e-08 32.2 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99824.1 - 1.6e-06 28.1 0.0 2.8e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99824.1 - 2.8e-06 26.9 0.1 4.7e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Cupin domain HTH_24 PF13412.6 ACS99824.1 - 0.046 13.3 0.2 0.64 9.6 0.0 2.7 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 ACS99824.1 - 0.078 12.8 0.0 1 9.2 0.0 2.3 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain EamA PF00892.20 ACS99825.1 - 2e-31 109.0 42.7 7.4e-18 65.0 15.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 ACS99825.1 - 1.5e-08 34.4 18.4 2.5e-08 33.6 18.4 1.4 1 1 0 1 1 1 1 Triose-phosphate Transporter family DUF1435 PF07256.12 ACS99825.1 - 6.9 6.9 13.1 0.72 10.0 3.4 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1435) Phosphorylase PF00343.20 ACS99826.1 - 1.5e-34 119.3 0.0 1.2e-25 89.9 0.0 3.1 2 1 0 2 2 2 2 Carbohydrate phosphorylase DUF3417 PF11897.8 ACS99826.1 - 0.0062 17.0 0.4 0.031 14.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3417) Methyltransf_11 PF08241.12 ACS99827.1 - 2.3e-26 92.3 0.0 4.8e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACS99827.1 - 2.9e-21 76.0 0.0 5.1e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACS99827.1 - 5e-17 62.1 0.0 6.6e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ACS99827.1 - 1.7e-16 60.3 0.0 2.7e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ACS99827.1 - 2.1e-15 57.0 0.0 2.9e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACS99827.1 - 5.9e-11 43.0 0.0 1.1e-10 42.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ACS99827.1 - 9.1e-08 31.8 0.0 1.5e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 ACS99827.1 - 2.4e-05 24.3 0.0 4.5e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 Hypothetical methyltransferase DREV PF05219.12 ACS99827.1 - 0.00019 20.6 0.0 0.00026 20.2 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_PK PF05891.12 ACS99827.1 - 0.00038 20.0 0.0 0.00055 19.5 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase PCMT PF01135.19 ACS99827.1 - 0.0038 17.0 0.0 0.005 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 ACS99827.1 - 0.0089 15.3 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 ACS99827.1 - 0.042 13.1 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain AGO_N PF18236.1 ACS99827.1 - 0.075 13.3 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Argonaute N domain Glyco_hydro_43 PF04616.14 ACS99828.1 - 1.5e-64 218.1 1.8 1.7e-64 217.9 1.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 EPTP PF03736.17 ACS99828.1 - 0.068 13.2 1.5 0.22 11.5 0.1 2.5 3 0 0 3 3 3 0 EPTP domain DUF2663 PF10864.8 ACS99829.1 - 1.3e-10 41.7 3.1 1.4e-10 41.6 3.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2663) FixQ PF05545.11 ACS99829.1 - 0.02 14.9 0.7 0.036 14.0 0.7 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ DHHC PF01529.20 ACS99829.1 - 0.04 14.0 0.4 0.049 13.7 0.4 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF2681 PF10883.8 ACS99829.1 - 0.07 13.5 0.1 0.097 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) PTS-HPr PF00381.19 ACS99830.1 - 0.014 15.6 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 0 PTS HPr component phosphorylation site Response_reg PF00072.24 ACS99831.1 - 4.8e-24 84.7 0.6 1.1e-23 83.6 0.1 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99831.1 - 1.6e-19 69.9 0.0 1.2e-18 67.2 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99831.1 - 2.3e-14 53.0 0.7 6e-09 35.8 0.1 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF2357 PF09823.9 ACS99831.1 - 0.043 13.1 6.1 1.3 8.2 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2357) HTH_31 PF13560.6 ACS99831.1 - 0.08 13.3 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain PIN_12 PF16289.5 ACS99831.1 - 0.081 13.4 5.2 1.9 8.9 0.9 2.3 2 0 0 2 2 2 0 PIN domain Glyco_hydro_38 PF18438.1 ACS99832.1 - 6.1e-37 126.1 0.0 1.3e-36 125.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain 1 Glyco_hydro_38N PF01074.22 ACS99832.1 - 2.7e-32 112.3 0.0 4.6e-32 111.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ACS99832.1 - 3.2e-21 76.4 0.0 1.8e-20 74.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ACS99832.1 - 3.8e-15 55.8 0.1 1.1e-14 54.4 0.1 1.8 2 0 0 2 2 2 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ACS99832.1 - 5.4e-06 26.4 0.0 2.1e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain His_kinase PF06580.13 ACS99833.1 - 1.2e-23 83.2 0.1 3.7e-23 81.6 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACS99833.1 - 1.2e-15 58.0 2.6 1.7e-15 57.5 2.6 1.2 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACS99833.1 - 2.7e-11 43.9 0.0 5.2e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACS99833.1 - 4.1e-06 27.1 0.0 0.00019 21.8 0.0 2.7 2 0 0 2 2 2 1 HAMP domain HATPase_c_2 PF13581.6 ACS99833.1 - 0.019 14.9 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain SwrA PF17423.2 ACS99833.1 - 0.041 13.9 0.3 0.13 12.3 0.3 1.8 1 0 0 1 1 1 0 Swarming motility protein Piezo_RRas_bdg PF12166.8 ACS99833.1 - 0.046 13.0 0.3 0.074 12.3 0.3 1.3 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain HATPase_c_5 PF14501.6 ACS99833.1 - 0.078 12.9 0.0 0.34 10.8 0.0 2.1 1 0 0 1 1 1 0 GHKL domain HATPase_c_3 PF13589.6 ACS99833.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase OppC_N PF12911.7 ACS99833.1 - 2.9 7.9 5.3 7.1 6.7 0.3 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C PspB PF06667.12 ACS99833.1 - 5.9 7.0 7.0 0.4 10.8 0.1 2.4 2 1 1 3 3 3 0 Phage shock protein B SBP_bac_1 PF01547.25 ACS99834.1 - 5.7e-21 75.8 4.5 9.3e-21 75.1 4.5 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Methyltransf_24 PF13578.6 ACS99834.1 - 0.034 15.2 0.0 0.28 12.2 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain His_kinase PF06580.13 ACS99835.1 - 1.9e-23 82.6 1.4 1.9e-23 82.6 1.4 3.0 3 1 1 4 4 4 1 Histidine kinase dCache_1 PF02743.18 ACS99835.1 - 1.1e-17 64.6 5.4 1.1e-17 64.6 5.4 2.7 3 0 0 3 3 3 1 Cache domain HATPase_c PF02518.26 ACS99835.1 - 2.1e-07 31.4 0.1 1.1e-06 29.1 0.0 2.2 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACS99835.1 - 2.4e-07 31.0 0.0 6e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 HAMP domain HlyE PF06109.13 ACS99835.1 - 0.0024 17.2 2.3 0.0063 15.9 2.3 1.7 1 0 0 1 1 1 1 Haemolysin E (HlyE) DUF2975 PF11188.8 ACS99835.1 - 0.0033 17.3 1.1 0.0074 16.2 1.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2975) PurS PF02700.14 ACS99835.1 - 0.011 15.9 0.0 2.3 8.4 0.0 3.1 3 0 0 3 3 3 0 Phosphoribosylformylglycinamidine (FGAM) synthase DUF4852 PF16144.5 ACS99835.1 - 0.19 11.9 2.7 0.61 10.2 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4852) Response_reg PF00072.24 ACS99836.1 - 8.7e-23 80.6 0.0 1.7e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99836.1 - 5.3e-19 68.3 0.0 1.8e-18 66.5 0.0 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99836.1 - 3.9e-15 55.5 0.4 6.6e-07 29.3 0.0 3.0 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family BORCS8 PF10167.9 ACS99836.1 - 0.15 12.0 0.2 0.39 10.7 0.0 1.8 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 8 BPD_transp_1 PF00528.22 ACS99837.1 - 1.2e-13 51.3 13.7 1.2e-13 51.3 13.7 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2748 PF10871.8 ACS99837.1 - 0.0036 16.0 0.0 0.0053 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2748) BPD_transp_1 PF00528.22 ACS99838.1 - 3.2e-11 43.3 28.1 2.5e-10 40.4 28.2 2.2 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_1 PF01547.25 ACS99839.1 - 2.3e-27 96.8 10.8 3.3e-27 96.3 10.8 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACS99839.1 - 2.1e-23 83.6 8.0 4e-23 82.6 8.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACS99839.1 - 0.1 13.3 1.2 0.25 12.0 0.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3502) GFO_IDH_MocA PF01408.22 ACS99840.1 - 8.5e-15 55.6 0.0 2.1e-14 54.3 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACS99840.1 - 1.8e-07 31.1 0.1 5.5e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain DapB_N PF01113.20 ACS99840.1 - 0.023 14.8 0.0 0.083 13.0 0.0 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus HTH_18 PF12833.7 ACS99841.1 - 1.5e-21 76.4 0.3 2.5e-21 75.7 0.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99841.1 - 2.3e-15 56.2 0.7 4.4e-10 39.4 0.1 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99841.1 - 1.3e-08 34.9 0.2 3.5e-08 33.4 0.0 1.7 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99841.1 - 0.00026 20.6 0.1 0.00042 20.0 0.1 1.4 1 0 0 1 1 1 1 Cupin domain Glyco_hydro_35 PF01301.19 ACS99842.1 - 2e-118 395.6 0.0 2.5e-118 395.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 ACS99842.1 - 8.8e-11 41.8 0.2 8e-10 38.6 0.0 2.2 2 1 0 2 2 2 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 ACS99842.1 - 1.2e-06 29.0 0.0 0.077 13.6 0.0 2.6 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain Cellulase PF00150.18 ACS99842.1 - 0.028 13.8 0.0 0.059 12.8 0.0 1.5 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) Beta_helix PF13229.6 ACS99843.1 - 2.7e-09 37.1 25.0 2.7e-09 37.1 25.0 4.6 1 1 2 3 3 3 2 Right handed beta helix region DUF1080 PF06439.11 ACS99843.1 - 1.1e-06 28.9 0.2 1.1e-06 28.9 0.2 3.7 4 1 0 4 4 4 2 Domain of Unknown Function (DUF1080) SLH PF00395.20 ACS99844.1 - 1.7e-35 120.8 2.9 2.8e-11 43.3 0.3 4.1 3 0 0 3 3 3 3 S-layer homology domain Beta_helix PF13229.6 ACS99844.1 - 2.2e-11 43.9 23.5 2.2e-11 43.9 23.5 3.7 1 1 2 3 3 3 2 Right handed beta helix region CBM9_1 PF06452.11 ACS99844.1 - 2.3e-08 34.2 0.0 6.6e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 Carbohydrate family 9 binding domain-like Laminin_G_3 PF13385.6 ACS99844.1 - 5e-05 23.5 14.0 0.017 15.3 0.0 4.9 4 1 1 5 5 5 2 Concanavalin A-like lectin/glucanases superfamily Big_7 PF17957.1 ACS99844.1 - 0.0035 18.1 0.0 0.0035 18.1 0.0 4.8 6 0 0 6 6 6 1 Bacterial Ig domain Y_Y_Y PF07495.13 ACS99844.1 - 0.062 13.3 0.6 0.32 11.0 0.6 2.2 1 0 0 1 1 1 0 Y_Y_Y domain fn3 PF00041.21 ACS99844.1 - 0.41 11.0 7.0 0.5 10.7 0.2 3.7 4 0 0 4 4 4 0 Fibronectin type III domain DUF3043 PF11241.8 ACS99845.1 - 0.055 13.5 3.7 0.55 10.2 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) 7TMR-DISM_7TM PF07695.11 ACS99845.1 - 0.1 12.5 6.9 0.18 11.7 6.9 1.4 1 1 0 1 1 1 0 7TM diverse intracellular signalling TraG_N PF07916.11 ACS99845.1 - 0.2 10.5 5.3 0.22 10.3 5.3 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region MatE PF01554.18 ACS99846.1 - 1.5e-43 148.3 47.2 2.7e-24 85.6 14.3 2.7 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ACS99846.1 - 7e-07 29.4 7.7 7e-07 29.4 7.7 4.9 3 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain BPD_transp_1 PF00528.22 ACS99847.1 - 1.6e-15 57.3 14.1 1.6e-15 57.3 14.1 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99848.1 - 2.3e-16 60.1 9.0 2.3e-16 60.1 9.0 2.4 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3502 PF12010.8 ACS99849.1 - 5.1e-21 75.7 0.7 1.9e-20 73.9 0.7 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACS99849.1 - 2.3e-10 40.9 6.6 2.3e-10 40.9 6.6 2.7 2 2 0 3 3 3 1 Bacterial extracellular solute-binding protein SLH PF00395.20 ACS99850.1 - 2.4e-34 117.1 6.7 1.7e-11 43.9 0.3 4.5 4 0 0 4 4 4 3 S-layer homology domain Pectate_lyase_3 PF12708.7 ACS99850.1 - 9.5e-29 100.8 15.1 1.8e-16 60.6 3.3 4.9 3 2 0 3 3 3 2 Pectate lyase superfamily protein CBM9_1 PF06452.11 ACS99850.1 - 1.5e-06 28.3 0.2 1.5e-06 28.3 0.2 3.1 3 0 0 3 3 3 1 Carbohydrate family 9 binding domain-like End_N_terminal PF12218.8 ACS99850.1 - 0.014 15.1 0.2 0.088 12.5 0.2 2.5 2 0 0 2 2 2 0 N terminal extension of bacteriophage endosialidase GFO_IDH_MocA PF01408.22 ACS99851.1 - 4e-27 95.4 0.0 5.7e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACS99851.1 - 6.3e-09 35.9 0.0 3e-07 30.4 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACS99851.1 - 0.0002 22.0 0.0 0.00031 21.4 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ACS99851.1 - 0.00039 20.8 0.0 0.0011 19.4 0.0 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ACS99851.1 - 0.029 14.9 0.0 0.066 13.8 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Glyco_hydro_3_C PF01915.22 ACS99852.1 - 3.4e-65 219.8 0.0 5.1e-65 219.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ACS99852.1 - 5.2e-64 216.6 0.0 8.2e-64 216.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain PA14 PF07691.12 ACS99852.1 - 3.5e-27 95.0 0.0 6.8e-27 94.1 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Fn3-like PF14310.6 ACS99852.1 - 8.3e-22 77.1 0.0 1.9e-21 75.9 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain CARDB PF07705.11 ACS99852.1 - 0.024 14.9 0.0 0.056 13.7 0.0 1.6 1 0 0 1 1 1 0 CARDB MR_MLE_C PF13378.6 ACS99853.1 - 4.6e-42 144.1 0.1 6.7e-42 143.5 0.1 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ACS99853.1 - 2.4e-24 85.8 0.6 1e-23 83.8 0.1 2.1 2 0 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_N PF05034.13 ACS99853.1 - 0.063 12.9 0.0 0.18 11.4 0.0 1.7 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase N-terminus Epimerase PF01370.21 ACS99854.1 - 3.4e-25 88.9 0.0 9.1e-25 87.5 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACS99854.1 - 1.5e-17 64.0 0.2 1.6e-15 57.4 0.0 2.7 1 1 1 3 3 3 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ACS99854.1 - 3.3e-12 46.0 0.0 4.4e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ACS99854.1 - 2e-09 37.6 0.0 5.7e-09 36.1 0.0 1.8 2 1 0 2 2 2 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ACS99854.1 - 4.6e-08 32.5 0.0 1.7e-06 27.4 0.0 2.1 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ACS99854.1 - 8.5e-07 28.4 0.0 0.00036 19.8 0.0 2.2 1 1 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 ACS99854.1 - 1.6e-06 27.5 0.4 0.0012 18.0 0.2 3.0 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 ACS99854.1 - 0.0018 17.8 0.1 0.0046 16.5 0.1 1.7 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ACS99854.1 - 0.014 14.8 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase DFP PF04127.15 ACS99854.1 - 0.033 14.0 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Sacchrp_dh_NADP PF03435.18 ACS99854.1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 ACS99854.1 - 0.081 13.5 0.0 0.16 12.6 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 ACS99854.1 - 0.11 12.6 0.1 0.19 11.9 0.1 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus BPD_transp_1 PF00528.22 ACS99855.1 - 7.7e-10 38.8 13.0 7.7e-10 38.8 13.0 2.4 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component CitMHS PF03600.16 ACS99855.1 - 1.5 7.9 14.1 0.27 10.4 8.0 2.2 2 0 0 2 2 2 0 Citrate transporter BPD_transp_1 PF00528.22 ACS99856.1 - 1.1e-15 57.9 12.2 1.1e-15 57.9 12.2 1.7 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component MNHE PF01899.16 ACS99856.1 - 0.08 12.7 1.3 0.23 11.2 1.3 1.8 1 0 0 1 1 1 0 Na+/H+ ion antiporter subunit CD47 PF04549.14 ACS99856.1 - 2.4 8.4 11.2 0.32 11.2 2.5 2.7 2 1 0 2 2 2 0 CD47 transmembrane region SBP_bac_1 PF01547.25 ACS99857.1 - 1.5e-14 54.7 1.5 1.5e-14 54.7 1.5 2.4 2 1 1 3 3 3 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACS99857.1 - 7.8e-13 48.9 0.1 7.8e-13 48.9 0.1 1.9 2 1 1 3 3 3 1 Bacterial extracellular solute-binding protein DUF4969 PF16339.5 ACS99857.1 - 0.18 12.2 0.0 0.35 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4969) HTH_AraC PF00165.23 ACS99858.1 - 1.6e-22 79.0 3.6 2.1e-10 40.4 0.7 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACS99858.1 - 4.3e-22 78.2 0.3 1e-21 77.0 0.3 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACS99858.1 - 1e-15 57.8 0.0 1.7e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain DUF4120 PF13496.6 ACS99858.1 - 0.041 14.2 0.0 0.093 13.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4120) Cupin_2 PF07883.11 ACS99858.1 - 0.052 13.3 0.0 0.091 12.5 0.0 1.3 1 0 0 1 1 1 0 Cupin domain Glyco_hydro_8 PF01270.17 ACS99859.1 - 8.3e-26 90.6 0.1 1.1e-25 90.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 8 SIS PF01380.22 ACS99860.1 - 7.6e-13 48.4 0.1 1.1e-12 47.9 0.1 1.3 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 ACS99860.1 - 2e-06 27.9 1.5 0.0047 16.9 0.1 2.3 1 1 1 2 2 2 2 SIS domain OMPdecase PF00215.24 ACS99861.1 - 5.2e-32 111.2 6.4 6.3e-32 111.0 6.4 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family PRAI PF00697.22 ACS99861.1 - 0.00082 19.2 2.1 0.0012 18.7 2.1 1.2 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase PEP_mutase PF13714.6 ACS99861.1 - 0.0012 18.3 0.2 0.0028 17.2 0.2 1.6 1 1 1 2 2 2 1 Phosphoenolpyruvate phosphomutase Ribul_P_3_epim PF00834.19 ACS99861.1 - 0.012 15.0 1.5 0.027 13.9 1.4 1.7 1 1 0 1 1 1 0 Ribulose-phosphate 3 epimerase family 4HFCP_synth PF04476.13 ACS99861.1 - 0.044 13.5 3.9 0.074 12.8 0.1 2.4 2 1 1 3 3 3 0 4-HFC-P synthase AP_endonuc_2 PF01261.24 ACS99861.1 - 0.097 12.1 0.0 0.44 10.0 0.0 2.1 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel HxlR PF01638.17 ACS99862.1 - 1.2e-36 124.5 0.4 1.4e-36 124.2 0.4 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix MarR PF01047.22 ACS99862.1 - 0.0086 16.0 0.1 0.017 15.1 0.1 1.5 1 0 0 1 1 1 1 MarR family PadR PF03551.14 ACS99862.1 - 0.02 14.8 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_34 PF13601.6 ACS99862.1 - 0.07 13.3 0.0 0.17 12.0 0.0 1.6 2 0 0 2 2 2 0 Winged helix DNA-binding domain Replic_Relax PF13814.6 ACS99862.1 - 0.1 12.6 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Replication-relaxation HTH_20 PF12840.7 ACS99862.1 - 0.14 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain MCPsignal PF00015.21 ACS99863.1 - 2.8e-33 115.1 35.9 6.4e-33 114.0 16.7 3.1 2 1 1 3 3 3 3 Methyl-accepting chemotaxis protein (MCP) signalling domain BLOC1_2 PF10046.9 ACS99863.1 - 0.018 15.3 22.4 2.1 8.7 0.2 5.4 3 3 2 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 P-mevalo_kinase PF04275.14 ACS99863.1 - 0.04 13.9 0.3 0.53 10.3 0.0 2.7 2 1 0 2 2 2 0 Phosphomevalonate kinase DUF948 PF06103.11 ACS99863.1 - 0.046 14.0 25.6 0.4 11.0 0.4 4.9 3 2 2 5 5 4 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 ACS99863.1 - 0.064 13.3 20.1 0.95 9.5 0.3 4.2 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) LOH1CR12 PF10158.9 ACS99863.1 - 0.17 11.9 10.7 1.1 9.3 0.2 3.4 1 1 2 3 3 3 0 Tumour suppressor protein CREPT PF16566.5 ACS99863.1 - 0.25 11.5 0.1 0.25 11.5 0.1 3.7 3 1 1 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour LPD38 PF18857.1 ACS99863.1 - 0.25 11.5 1.0 0.54 10.4 0.1 2.0 2 0 0 2 2 2 0 Large polyvalent protein associated domain 38 Nuc_recep-AF1 PF11825.8 ACS99863.1 - 0.3 11.2 10.3 0.29 11.2 4.0 3.0 2 2 1 3 3 3 0 Nuclear/hormone receptor activator site AF-1 Occludin_ELL PF07303.13 ACS99863.1 - 0.5 11.1 7.8 32 5.3 0.1 4.6 2 2 4 6 6 6 0 Occludin homology domain NPV_P10 PF05531.12 ACS99863.1 - 1.3 9.5 13.4 3 8.4 0.1 4.6 3 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 ACS99863.1 - 1.4 8.9 23.8 3.6 7.6 0.9 3.9 2 2 2 4 4 4 0 Laminin Domain II Sec34 PF04136.15 ACS99863.1 - 2.1 8.2 17.7 0.21 11.5 1.3 4.0 3 1 0 4 4 4 0 Sec34-like family PMC2NT PF08066.12 ACS99863.1 - 3.2 8.5 13.6 5.9 7.6 0.6 4.2 2 2 1 3 3 3 0 PMC2NT (NUC016) domain DUF4763 PF15960.5 ACS99863.1 - 5 6.4 9.7 2.9 7.2 5.6 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF4763) Fib_alpha PF08702.10 ACS99863.1 - 6.2 7.0 22.3 1.2 9.3 4.4 4.0 2 2 1 3 3 3 0 Fibrinogen alpha/beta chain family IFT57 PF10498.9 ACS99863.1 - 6.7 5.6 21.6 0.23 10.4 4.9 2.9 2 2 0 2 2 2 0 Intra-flagellar transport protein 57 KxDL PF10241.9 ACS99863.1 - 7.7 6.9 9.7 2 8.8 0.4 3.9 2 1 1 4 4 4 0 Uncharacterized conserved protein ArsR PF09824.9 ACS99863.1 - 8.8 5.9 9.2 0.5 10.0 0.2 3.0 4 0 0 4 4 4 0 ArsR transcriptional regulator CC2-LZ PF16516.5 ACS99863.1 - 9.7 6.6 10.9 3.4 8.1 0.2 4.0 2 1 1 4 4 4 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ROK PF00480.20 ACS99867.1 - 1.1e-67 228.6 0.0 1.3e-67 228.4 0.0 1.0 1 0 0 1 1 1 1 ROK family PMI_typeI PF01238.21 ACS99868.1 - 1.9e-47 162.3 0.0 2.8e-47 161.7 0.0 1.2 1 1 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 ACS99868.1 - 2.6e-07 30.2 0.0 0.0058 16.3 0.0 2.8 2 0 0 2 2 2 2 Cupin domain Cupin_1 PF00190.22 ACS99868.1 - 0.0028 17.3 0.0 0.15 11.6 0.0 2.3 2 0 0 2 2 2 1 Cupin AraC_binding PF02311.19 ACS99868.1 - 0.0046 16.9 0.0 2.6 7.9 0.0 2.3 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.12 ACS99868.1 - 0.0059 16.3 1.0 2.9 7.6 0.2 3.4 2 1 0 2 2 2 2 Protein of unknown function (DUF861) Peripla_BP_3 PF13377.6 ACS99869.1 - 2.3e-30 106.1 0.0 4.4e-30 105.2 0.0 1.5 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACS99869.1 - 2.6e-09 36.9 0.0 1.2e-08 34.8 0.0 1.8 2 0 0 2 2 2 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACS99869.1 - 1.3e-05 24.9 0.0 2.4e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_10 PF04967.12 ACS99869.1 - 0.0011 18.7 0.1 0.014 15.2 0.0 2.2 2 0 0 2 2 2 1 HTH DNA binding domain HTH_23 PF13384.6 ACS99869.1 - 0.015 15.1 0.0 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain HTH_11 PF08279.12 ACS99869.1 - 0.017 15.1 0.1 0.056 13.4 0.0 1.8 2 0 0 2 2 2 0 HTH domain HTH_24 PF13412.6 ACS99869.1 - 0.057 13.0 0.1 0.18 11.4 0.1 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_19 PF12844.7 ACS99869.1 - 0.12 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2500 PF10694.9 ACS99870.1 - 4.3e-23 81.9 0.4 5e-23 81.7 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2500) DUF3592 PF12158.8 ACS99870.1 - 0.11 12.6 0.3 0.13 12.4 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3592) TMEMspv1-c74-12 PF11044.8 ACS99870.1 - 0.15 12.1 0.8 0.24 11.4 0.8 1.3 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein TetR_N PF00440.23 ACS99871.1 - 1.4e-15 56.8 0.7 2.5e-15 56.0 0.7 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_24 PF17932.1 ACS99871.1 - 0.0067 16.7 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain YfcL PF08891.11 ACS99871.1 - 0.1 13.0 0.7 11 6.4 0.0 2.8 4 0 0 4 4 4 0 YfcL protein ABC2_membrane_3 PF12698.7 ACS99872.1 - 9.5e-35 120.3 12.8 1.3e-20 73.8 5.7 2.2 2 0 0 2 2 2 2 ABC-2 family transporter protein DUF3533 PF12051.8 ACS99872.1 - 6.5e-15 54.9 15.0 2.8e-10 39.7 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3533) ABC2_membrane PF01061.24 ACS99872.1 - 5.4e-08 32.5 13.9 1.5e-07 31.0 13.8 1.7 1 1 0 1 1 1 1 ABC-2 type transporter Prominin PF05478.11 ACS99872.1 - 0.054 11.5 0.0 0.11 10.4 0.0 1.5 1 1 0 1 1 1 0 Prominin RapA_C PF12137.8 ACS99872.1 - 0.2 10.6 1.8 0.36 9.8 1.8 1.3 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal TraP PF07296.11 ACS99872.1 - 0.29 10.3 0.5 0.64 9.2 0.5 1.5 1 0 0 1 1 1 0 TraP protein ABC2_membrane_2 PF12679.7 ACS99872.1 - 3.7 6.8 15.2 50 3.0 13.7 2.7 2 1 0 2 2 2 0 ABC-2 family transporter protein Sulfatase PF00884.23 ACS99873.1 - 1.3e-41 143.0 1.7 1.7e-41 142.6 1.7 1.1 1 0 0 1 1 1 1 Sulfatase DUF1501 PF07394.12 ACS99873.1 - 0.0016 17.6 0.0 0.0033 16.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) Phosphodiest PF01663.22 ACS99873.1 - 0.0074 15.9 0.0 0.031 13.9 0.0 1.9 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1772 PF08592.11 ACS99873.1 - 0.68 10.3 4.4 1.6 9.1 2.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) DUF308 PF03729.13 ACS99874.1 - 0.0061 16.9 8.2 0.21 11.9 1.1 2.1 1 1 1 2 2 2 2 Short repeat of unknown function (DUF308) PGPGW PF09656.10 ACS99874.1 - 0.017 14.6 0.5 0.017 14.6 0.5 2.1 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) DUF4267 PF14087.6 ACS99874.1 - 0.056 13.5 0.5 0.064 13.3 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4267) DUF202 PF02656.15 ACS99874.1 - 0.13 12.8 5.8 3.6 8.1 1.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF202) dCMP_cyt_deam_1 PF00383.23 ACS99876.1 - 4.5e-19 68.2 0.1 6.2e-19 67.8 0.1 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ACS99876.1 - 2e-14 53.5 0.0 2.5e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 ACS99876.1 - 1.3e-05 25.2 0.3 2.1e-05 24.6 0.3 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC_N PF08210.11 ACS99876.1 - 2.2e-05 24.5 0.2 2.8e-05 24.1 0.2 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC2 PF18772.1 ACS99876.1 - 3.7e-05 23.8 0.6 4.9e-05 23.5 0.6 1.2 1 0 0 1 1 1 1 APOBEC2 NAD2 PF18782.1 ACS99876.1 - 0.00046 20.4 0.2 0.00064 19.9 0.2 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 Bd3614-deam PF14439.6 ACS99876.1 - 0.00067 19.7 0.8 0.13 12.3 0.8 2.1 1 1 0 1 1 1 1 Bd3614-like deaminase NAD1 PF18778.1 ACS99876.1 - 0.0025 17.9 0.4 0.0032 17.6 0.4 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC3 PF18771.1 ACS99876.1 - 0.0082 16.3 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 APOBEC3 APOBEC4_like PF18774.1 ACS99876.1 - 0.026 14.4 0.0 0.038 13.9 0.0 1.2 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Inv-AAD PF18785.1 ACS99876.1 - 0.033 14.0 1.7 0.099 12.5 1.6 1.7 1 1 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase XOO_2897-deam PF14440.6 ACS99876.1 - 0.067 13.3 0.1 0.096 12.8 0.1 1.4 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase DUF1450 PF07293.11 ACS99876.1 - 0.11 12.3 0.1 0.28 11.0 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1450) Spore_YunB PF09560.10 ACS99877.1 - 9.8e-28 96.0 1.9 2.1e-27 94.9 1.9 1.5 1 0 0 1 1 1 1 Sporulation protein YunB (Spo_YunB) DUF973 PF06157.11 ACS99877.1 - 0.022 13.8 2.7 2.1 7.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF973) Peptidase_M23 PF01551.22 ACS99878.1 - 4.5e-19 68.4 0.0 8.1e-19 67.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M23 Radical_SAM PF04055.21 ACS99879.1 - 2.3e-12 47.6 0.1 4.2e-12 46.7 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily LIAS_N PF16881.5 ACS99879.1 - 2.9e-12 46.9 1.9 1.5e-11 44.7 0.7 2.2 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family TGT PF01702.18 ACS99879.1 - 0.0075 15.5 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase TYW3 PF02676.14 ACS99879.1 - 0.028 13.8 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase TYW3 DUF1027 PF06265.11 ACS99880.1 - 1.7e-34 117.7 1.9 1.7e-34 117.7 1.9 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1027) CENP-B_dimeris PF09026.10 ACS99880.1 - 3.8 8.0 8.4 0.68 10.4 1.7 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF3506 PF12014.8 ACS99880.1 - 5.5 7.0 9.2 26 4.8 9.2 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3506) NAD_kinase PF01513.21 ACS99881.1 - 3.3e-21 75.7 0.0 4.6e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase MAF_flag10 PF01973.18 ACS99881.1 - 0.003 17.3 0.0 1.4 8.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function DUF115 DAGK_cat PF00781.24 ACS99881.1 - 0.025 14.2 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain LmjF365940-deam PF14421.6 ACS99881.1 - 0.09 12.4 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases Gate PF07670.14 ACS99882.1 - 9.2e-10 38.8 16.6 1.7e-05 25.1 1.4 3.0 3 2 0 3 3 3 2 Nucleoside recognition Peptidase_M56 PF05569.11 ACS99882.1 - 0.26 10.5 1.1 1.7 7.8 0.9 1.9 2 0 0 2 2 2 0 BlaR1 peptidase M56 Bac_globin PF01152.21 ACS99884.1 - 1.9e-30 105.5 0.0 2.6e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial-like globin ZT_dimer PF16916.5 ACS99884.1 - 0.15 12.2 0.0 0.32 11.2 0.0 1.6 2 0 0 2 2 2 0 Dimerisation domain of Zinc Transporter DUF2225 PF09986.9 ACS99885.1 - 8.6e-54 182.5 1.5 9.8e-54 182.3 1.5 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_12 PF13424.6 ACS99885.1 - 0.00066 19.9 3.8 0.23 11.8 0.8 2.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ACS99885.1 - 0.0051 16.6 1.5 0.081 12.8 0.2 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ACS99885.1 - 0.0064 16.6 2.4 7.4 7.1 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 ACS99885.1 - 0.0081 16.2 0.7 1.6 9.0 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ACS99885.1 - 0.03 14.9 0.0 0.21 12.3 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DDE_Tnp_4 PF13359.6 ACS99885.1 - 0.05 13.3 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease RPN7 PF10602.9 ACS99885.1 - 0.12 12.1 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 26S proteasome subunit RPN7 DUF5519 PF17648.1 ACS99885.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5519) PhnA_Zn_Ribbon PF08274.12 ACS99886.1 - 0.03 14.3 0.2 0.046 13.7 0.2 1.4 1 0 0 1 1 1 0 PhnA Zinc-Ribbon zf-Di19 PF05605.12 ACS99886.1 - 0.035 14.4 0.5 0.052 13.8 0.5 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding YycC PF14174.6 ACS99887.1 - 3.1e-28 97.3 5.4 3.7e-28 97.1 5.4 1.1 1 0 0 1 1 1 1 YycC-like protein HTH_3 PF01381.22 ACS99887.1 - 0.01 15.8 0.3 0.022 14.8 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix Peptidase_M3 PF01432.20 ACS99888.1 - 1.6e-19 70.6 2.7 4.8e-19 69.0 1.2 2.3 2 1 0 2 2 2 1 Peptidase family M3 Peptidase_M3_N PF08439.10 ACS99888.1 - 2.3e-10 40.6 0.0 1.2e-09 38.3 0.0 2.3 2 0 0 2 2 2 1 Oligopeptidase F MTES_1575 PF18741.1 ACS99889.1 - 3.1e-05 24.1 0.0 5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 REase_MTES_1575 DUF559 PF04480.12 ACS99889.1 - 0.00056 19.7 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF559) CBS PF00571.28 ACS99890.1 - 3.5e-16 59.4 1.0 1.4e-07 31.8 0.1 2.5 2 0 0 2 2 2 2 CBS domain HTH_11 PF08279.12 ACS99890.1 - 8.2e-09 35.3 0.0 1.4e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 HTH domain HTH_DeoR PF08220.12 ACS99890.1 - 6.1e-05 22.7 0.0 0.00013 21.6 0.0 1.6 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain GntR PF00392.21 ACS99890.1 - 0.00024 20.7 0.0 0.00046 19.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_Crp_2 PF13545.6 ACS99890.1 - 0.012 15.5 0.0 0.04 13.9 0.0 1.9 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HrcA_DNA-bdg PF03444.15 ACS99890.1 - 0.033 13.8 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HTH_10 PF04967.12 ACS99890.1 - 0.12 12.2 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain HTH_3 PF01381.22 ACS99890.1 - 0.14 12.2 0.1 0.81 9.8 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix HTH_17 PF12728.7 ACS99890.1 - 0.2 11.9 0.0 0.46 10.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Kinase-PPPase PF03618.14 ACS99891.1 - 2.9e-94 315.6 0.0 3.3e-94 315.4 0.0 1.0 1 0 0 1 1 1 1 Kinase/pyrophosphorylase FBPase_glpX PF03320.13 ACS99892.1 - 4.8e-139 462.5 1.3 5.4e-139 462.3 1.3 1.0 1 0 0 1 1 1 1 Bacterial fructose-1,6-bisphosphatase, glpX-encoded NDK PF00334.19 ACS99893.1 - 2.1e-53 179.9 0.0 2.6e-53 179.7 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase TAL_FSA PF00923.19 ACS99894.1 - 9.3e-53 179.4 0.0 3.4e-52 177.6 0.0 1.7 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Wzz PF02706.15 ACS99895.1 - 2.9e-12 46.7 4.2 2.9e-12 46.7 4.2 2.3 3 0 0 3 3 3 1 Chain length determinant protein GNVR PF13807.6 ACS99895.1 - 0.00055 19.8 0.3 0.00055 19.8 0.3 2.1 2 0 0 2 2 2 1 G-rich domain on putative tyrosine kinase MARVEL PF01284.23 ACS99895.1 - 0.078 13.0 0.1 1.6 8.8 0.0 2.1 2 0 0 2 2 2 0 Membrane-associating domain NTP_transferase PF00483.23 ACS99896.1 - 3.3e-35 121.9 0.0 4.3e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACS99896.1 - 4.4e-09 36.9 0.0 5.8e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glycos_transf_2 PF00535.26 ACS99896.1 - 0.0018 18.1 0.0 0.0029 17.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 IspD PF01128.19 ACS99896.1 - 0.0081 15.9 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Smr PF01713.21 ACS99896.1 - 0.039 14.3 0.1 0.97 9.8 0.0 2.5 2 1 0 2 2 2 0 Smr domain CTP_transf_3 PF02348.19 ACS99896.1 - 0.078 12.9 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Cytidylyltransferase DUF3137 PF11335.8 ACS99896.1 - 0.089 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3137) Bac_transf PF02397.16 ACS99897.1 - 5.4e-71 238.0 0.1 6.3e-71 237.8 0.1 1.0 1 0 0 1 1 1 1 Bacterial sugar transferase NTP_transferase PF00483.23 ACS99898.1 - 1.6e-29 103.2 0.0 2.1e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase MannoseP_isomer PF01050.18 ACS99898.1 - 1.4e-11 44.5 0.6 9.5e-11 41.8 0.3 2.4 2 1 0 2 2 2 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.11 ACS99898.1 - 6.8e-07 28.9 0.0 1.3e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Cupin domain EutQ PF06249.12 ACS99898.1 - 0.0043 16.8 0.0 0.0079 16.0 0.0 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Ectoine_synth PF06339.12 ACS99898.1 - 0.048 13.8 0.0 0.096 12.9 0.0 1.4 1 0 0 1 1 1 0 Ectoine synthase HARE-HTH PF05066.13 ACS99898.1 - 0.051 14.0 0.1 15 6.1 0.0 2.5 2 0 0 2 2 2 0 HB1, ASXL, restriction endonuclease HTH domain DMSP_lyase PF16867.5 ACS99898.1 - 0.066 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase AraC_binding PF02311.19 ACS99898.1 - 0.082 12.8 0.1 0.29 11.0 0.0 1.9 2 0 0 2 2 2 0 AraC-like ligand binding domain Pectate_lyase_3 PF12708.7 ACS99899.1 - 1.4e-14 54.4 0.4 3.1e-09 37.0 0.1 2.5 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 ACS99899.1 - 0.011 15.4 0.0 0.032 13.9 0.0 1.8 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase Wzz PF02706.15 ACS99900.1 - 4.4e-13 49.3 1.3 4.4e-13 49.3 1.3 2.8 3 1 1 4 4 4 1 Chain length determinant protein Yip1 PF04893.17 ACS99900.1 - 0.0067 16.2 0.1 1.4 8.6 0.0 2.1 2 0 0 2 2 2 2 Yip1 domain GNVR PF13807.6 ACS99900.1 - 0.022 14.7 0.3 0.022 14.7 0.3 2.2 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase Mito_carr PF00153.27 ACS99900.1 - 0.11 12.4 0.0 0.33 10.9 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial carrier protein DUF3139 PF11337.8 ACS99900.1 - 0.43 11.3 4.0 4.1 8.1 0.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3139) AAA_31 PF13614.6 ACS99901.1 - 1.6e-14 54.2 0.1 3.8e-14 53.0 0.1 1.6 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 ACS99901.1 - 8.7e-11 42.0 0.1 1.5e-10 41.2 0.1 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 ACS99901.1 - 2.9e-10 40.0 0.0 6.9e-10 38.8 0.0 1.5 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase MipZ PF09140.11 ACS99901.1 - 1.4e-08 34.4 0.0 3.2e-08 33.2 0.0 1.6 1 1 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 ACS99901.1 - 2e-05 24.2 0.0 6.5e-05 22.5 0.0 1.9 1 1 1 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 ACS99901.1 - 4.9e-05 22.9 0.0 8.6e-05 22.1 0.0 1.4 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Zeta_toxin PF06414.12 ACS99901.1 - 0.0042 16.4 0.0 0.0059 15.9 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.6 ACS99901.1 - 0.0072 15.9 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 ACS99901.1 - 0.0089 15.2 0.1 0.16 11.2 0.0 2.1 1 1 0 2 2 2 1 Anion-transporting ATPase SRP54 PF00448.22 ACS99901.1 - 0.023 14.3 0.0 0.095 12.3 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain VirC1 PF07015.11 ACS99901.1 - 0.028 13.7 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 VirC1 protein CLP1_P PF16575.5 ACS99901.1 - 0.039 13.7 0.0 0.17 11.7 0.0 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MeaB PF03308.16 ACS99901.1 - 0.12 11.3 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Glycos_transf_2 PF00535.26 ACS99902.1 - 8.3e-19 68.0 0.0 1.1e-18 67.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACS99902.1 - 1.4e-18 67.7 0.0 2e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ACS99902.1 - 0.001 19.0 0.0 0.002 18.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 ACS99902.1 - 0.022 14.2 0.0 0.13 11.7 0.0 2.1 1 1 0 1 1 1 0 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 ACS99902.1 - 0.038 13.5 0.0 0.086 12.3 0.0 1.7 1 1 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_tranf_2_5 PF13712.6 ACS99902.1 - 0.17 11.5 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family Wzy_C PF04932.15 ACS99903.1 - 1.3e-07 31.4 5.7 1.3e-07 31.4 5.7 4.2 4 2 0 4 4 4 1 O-Antigen ligase PhoR PF11808.8 ACS99903.1 - 0.023 15.1 3.6 0.023 15.1 3.6 4.6 4 1 1 5 5 5 0 Phosphate regulon sensor protein PhoR UPF0139 PF03669.13 ACS99903.1 - 0.44 10.4 3.9 1.6 8.6 3.9 2.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) Glycos_transf_1 PF00534.20 ACS99904.1 - 1.1e-30 106.4 0.0 2e-30 105.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99904.1 - 7.3e-28 97.7 0.0 2.2e-27 96.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACS99904.1 - 1.8e-26 93.2 0.4 4.2e-26 91.9 0.4 1.7 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACS99904.1 - 4.2e-11 43.5 0.7 4.2e-11 43.5 0.7 2.1 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ACS99904.1 - 5.5e-11 42.7 0.4 1.7e-10 41.2 0.1 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Polysacc_synt_3 PF13440.6 ACS99905.1 - 1e-15 57.7 13.0 1e-15 57.7 13.0 2.2 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Polysacc_synt PF01943.17 ACS99905.1 - 3.9e-12 46.1 18.0 3.9e-12 46.1 18.0 2.2 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.6 ACS99905.1 - 1.6e-09 37.9 3.3 1.6e-09 37.9 3.3 4.2 3 1 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain Glycos_transf_1 PF00534.20 ACS99906.1 - 8.2e-34 116.6 0.0 1.7e-33 115.6 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99906.1 - 1e-22 81.0 0.0 1.9e-22 80.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACS99906.1 - 9.7e-21 74.5 0.5 1.9e-20 73.6 0.5 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACS99906.1 - 5.3e-14 53.0 0.1 1.5e-13 51.5 0.1 1.8 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.20 ACS99907.1 - 4.8e-35 120.6 0.0 6.9e-35 120.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99907.1 - 5.5e-24 85.1 0.0 1.2e-23 84.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACS99907.1 - 1.4e-11 44.6 0.2 7.4e-11 42.3 0.1 2.0 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 ACS99907.1 - 1.7e-11 44.3 0.0 4e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ACS99907.1 - 4.9e-10 40.1 0.6 9.3e-10 39.2 0.6 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain V4R PF02830.18 ACS99907.1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 V4R domain Glycos_transf_1 PF00534.20 ACS99908.1 - 1.3e-28 99.6 0.0 2.2e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99908.1 - 9.1e-22 77.9 0.0 1.5e-21 77.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACS99908.1 - 2.8e-10 40.5 0.1 4.3e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 ACS99908.1 - 0.013 15.8 0.0 0.029 14.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Hpr_kinase_C PF07475.12 ACS99909.1 - 0.00047 19.7 0.0 0.00073 19.1 0.0 1.2 1 0 0 1 1 1 1 HPr Serine kinase C-terminal domain ATPase PF06745.13 ACS99909.1 - 0.0016 17.9 0.0 0.0024 17.2 0.0 1.2 1 0 0 1 1 1 1 KaiC ABC_tran PF00005.27 ACS99909.1 - 0.0017 18.9 0.0 0.0023 18.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter CoaE PF01121.20 ACS99909.1 - 0.033 13.9 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_29 PF13555.6 ACS99909.1 - 0.044 13.5 0.4 0.16 11.8 0.1 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_33 PF13671.6 ACS99909.1 - 0.05 13.8 0.0 0.076 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain PqqD PF05402.12 ACS99910.1 - 4.1e-20 71.8 0.1 5.3e-20 71.5 0.1 1.1 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) DUF4777 PF16007.5 ACS99910.1 - 0.0033 17.6 0.0 0.0064 16.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4777) NARG2_C PF10505.9 ACS99910.1 - 0.055 13.0 0.1 0.1 12.1 0.1 1.4 1 1 0 1 1 1 0 NMDA receptor-regulated gene protein 2 C-terminus N2227 PF07942.12 ACS99910.1 - 0.14 11.3 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 N2227-like protein Transglut_core3 PF13471.6 ACS99911.1 - 2.6e-25 88.6 0.0 3.1e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Transglutaminase-like superfamily NTP_transf_5 PF14907.6 ACS99912.1 - 2.9e-57 194.2 2.2 4.6e-57 193.5 2.2 1.3 1 0 0 1 1 1 1 Uncharacterised nucleotidyltransferase ABC_tran PF00005.27 ACS99913.1 - 5.7e-33 114.3 0.0 1.3e-32 113.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ACS99913.1 - 3.1e-13 50.0 11.9 4.6e-13 49.4 11.9 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ACS99913.1 - 5.3e-10 39.1 0.8 1.1e-06 28.3 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACS99913.1 - 5.9e-05 22.7 0.0 0.00013 21.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF87 PF01935.17 ACS99913.1 - 0.00039 20.6 0.4 0.0062 16.7 0.0 2.6 3 0 0 3 3 3 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 ACS99913.1 - 0.00044 20.2 0.0 0.00083 19.3 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ACS99913.1 - 0.013 15.9 0.1 0.036 14.4 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ACS99913.1 - 0.015 15.6 0.5 0.42 10.9 0.4 2.6 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ACS99913.1 - 0.045 14.0 0.3 1.2 9.4 0.1 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 ACS99913.1 - 0.071 12.8 0.1 0.22 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 ACS99913.1 - 0.11 13.0 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACS99913.1 - 0.11 12.6 0.0 0.33 11.1 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA PF00004.29 ACS99913.1 - 0.11 12.9 0.3 0.86 10.0 0.3 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ACS99913.1 - 0.15 11.8 0.2 0.47 10.2 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ACS99913.1 - 0.16 11.7 0.0 0.83 9.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_31 PF13614.6 ACS99915.1 - 3.8e-07 30.2 0.0 1.3e-06 28.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ACS99915.1 - 2.1e-05 24.2 1.4 9.2e-05 22.1 0.3 2.3 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 ACS99915.1 - 2.9e-05 24.1 0.1 0.0005 20.1 0.1 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 ACS99915.1 - 0.00022 20.7 0.7 0.0023 17.4 0.1 2.1 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 ACS99915.1 - 0.0017 17.9 0.5 0.2 11.1 0.0 2.2 2 0 0 2 2 2 2 Cellulose biosynthesis protein BcsQ ATPase_2 PF01637.18 ACS99915.1 - 0.016 15.1 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 ACS99915.1 - 0.043 13.6 0.2 0.19 11.4 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein CLP1_P PF16575.5 ACS99915.1 - 0.043 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_24 PF13479.6 ACS99915.1 - 0.047 13.4 0.0 0.32 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 ACS99915.1 - 0.068 13.2 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ACS99915.1 - 0.068 12.3 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 ACS99915.1 - 0.073 13.0 0.2 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 ACS99916.1 - 1.1e-77 260.8 1.4 1.3e-77 260.5 1.4 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 ACS99916.1 - 0.00034 20.2 0.0 0.00071 19.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 ACS99916.1 - 0.00083 18.8 0.1 0.0021 17.5 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_28 PF13521.6 ACS99916.1 - 0.0014 18.9 0.0 0.0028 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Pox_A32 PF04665.12 ACS99916.1 - 0.0016 17.9 0.2 0.0059 16.1 0.0 2.0 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_16 PF13191.6 ACS99916.1 - 0.0021 18.5 0.0 0.0046 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_32 PF13654.6 ACS99916.1 - 0.0037 16.1 0.0 0.0061 15.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ACS99916.1 - 0.0041 16.9 0.0 0.017 14.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 ACS99916.1 - 0.0094 16.1 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain ABC_tran PF00005.27 ACS99916.1 - 0.011 16.3 0.1 0.022 15.3 0.1 1.5 1 0 0 1 1 1 0 ABC transporter IIGP PF05049.13 ACS99916.1 - 0.016 14.3 0.0 0.029 13.4 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Bac_DnaA PF00308.18 ACS99916.1 - 0.024 14.5 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein Sigma54_activat PF00158.26 ACS99916.1 - 0.027 14.2 0.0 0.05 13.3 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_29 PF13555.6 ACS99916.1 - 0.029 14.1 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ACS99916.1 - 0.031 14.8 0.4 0.062 13.8 0.4 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ACS99916.1 - 0.036 13.8 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Zeta_toxin PF06414.12 ACS99916.1 - 0.039 13.2 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin PIF1 PF05970.14 ACS99916.1 - 0.04 13.1 0.0 0.064 12.4 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase Septin PF00735.18 ACS99916.1 - 0.041 13.2 0.2 0.096 11.9 0.0 1.7 2 0 0 2 2 2 0 Septin AAA_24 PF13479.6 ACS99916.1 - 0.047 13.4 0.0 0.1 12.3 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_19 PF13245.6 ACS99916.1 - 0.056 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 ACS99916.1 - 0.057 12.3 0.0 0.1 11.5 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 ACS99916.1 - 0.074 13.1 0.5 0.25 11.3 0.1 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 ACS99916.1 - 0.075 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase VirE PF05272.11 ACS99916.1 - 0.081 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Virulence-associated protein E AAA_22 PF13401.6 ACS99916.1 - 0.1 12.9 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ACS99916.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_2 PF07724.14 ACS99916.1 - 0.12 12.4 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 ACS99916.1 - 0.12 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein NTPase_1 PF03266.15 ACS99916.1 - 0.13 12.2 0.0 0.36 10.7 0.0 1.8 1 0 0 1 1 1 0 NTPase ATP-synt_ab PF00006.25 ACS99916.1 - 0.13 11.8 0.1 0.27 10.9 0.1 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain T2SSF PF00482.23 ACS99917.1 - 8.3e-15 54.8 0.2 8.3e-15 54.8 0.2 1.8 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein F DUF2976 PF11190.8 ACS99917.1 - 0.0092 15.8 2.5 1.3 8.8 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2976) DUF485 PF04341.12 ACS99917.1 - 2.9 7.9 10.5 0.73 9.8 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF485 T2SSF PF00482.23 ACS99918.1 - 2.7e-10 40.3 0.1 5.7e-10 39.2 0.1 1.6 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein F Ribosomal_S21 PF01165.20 ACS99918.1 - 0.045 13.5 0.0 0.19 11.5 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein S21 Sensor PF13796.6 ACS99918.1 - 4.2 7.4 12.5 0.34 10.9 2.8 2.8 3 0 0 3 3 3 0 Putative sensor Flp1_like PF16982.5 ACS99919.1 - 7.3e-18 63.7 1.7 8.8e-18 63.4 1.7 1.1 1 0 0 1 1 1 1 Putative Flagellin, Flp1-like, domain Holin_BlyA PF05102.12 ACS99919.1 - 0.0036 17.2 1.0 0.0044 16.9 1.0 1.2 1 0 0 1 1 1 1 holin, BlyA family DUF2572 PF10833.8 ACS99919.1 - 0.041 13.6 0.2 0.045 13.5 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) Class_IIIsignal PF04021.12 ACS99919.1 - 0.61 10.1 8.7 0.82 9.7 8.7 1.2 1 0 0 1 1 1 0 Class III signal peptide TadE PF07811.12 ACS99920.1 - 0.0021 18.3 1.2 0.0044 17.3 1.2 1.6 1 0 0 1 1 1 1 TadE-like protein TadE PF07811.12 ACS99921.1 - 0.11 12.8 0.3 0.33 11.2 0.3 2.0 1 0 0 1 1 1 0 TadE-like protein Tad PF13400.6 ACS99921.1 - 0.16 12.3 1.6 0.57 10.5 1.6 2.0 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like Tape_meas_lam_C PF09718.10 ACS99921.1 - 2.7 8.2 6.6 1.3 9.3 0.4 3.4 4 0 0 4 4 4 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) TadE PF07811.12 ACS99922.1 - 4.5e-05 23.6 7.2 0.00013 22.2 7.2 1.9 1 0 0 1 1 1 1 TadE-like protein MG2 PF01835.19 ACS99922.1 - 0.0037 17.7 0.1 0.0095 16.4 0.1 1.8 1 0 0 1 1 1 1 MG2 domain DUF4307 PF14155.6 ACS99922.1 - 0.48 10.3 3.4 0.68 9.8 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) Peptidase_A24 PF01478.18 ACS99923.1 - 5.9e-17 62.0 20.2 5.9e-17 62.0 20.2 1.5 2 0 0 2 2 2 1 Type IV leader peptidase family DUF2108 PF09881.9 ACS99923.1 - 1.9 8.5 9.5 8.2 6.5 1.2 2.9 1 1 2 3 3 3 0 Predicted membrane protein (DUF2108) FHA PF00498.26 ACS99924.1 - 1.4e-08 35.0 0.0 2.6e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ACS99924.1 - 0.00052 20.3 0.0 0.0011 19.3 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF1731 PF08338.11 ACS99925.1 - 2e-21 75.6 0.2 5.2e-21 74.2 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) Epimerase PF01370.21 ACS99925.1 - 1.6e-17 63.7 0.1 1.6e-12 47.4 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACS99925.1 - 1.5e-07 31.2 0.1 6.7e-06 25.7 0.1 2.6 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ACS99925.1 - 3.6e-05 23.8 0.2 4.6e-05 23.4 0.2 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ACS99925.1 - 0.00029 20.1 0.2 0.00065 18.9 0.1 1.5 1 1 0 1 1 1 1 Male sterility protein NAD_binding_7 PF13241.6 ACS99925.1 - 0.0028 18.1 0.0 0.0049 17.3 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding 3Beta_HSD PF01073.19 ACS99925.1 - 0.0033 16.5 0.0 0.0044 16.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ACS99925.1 - 0.0069 15.5 0.1 0.011 14.8 0.1 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 ACS99925.1 - 0.0085 16.0 0.3 0.032 14.2 0.2 1.9 1 1 1 2 2 2 1 KR domain Semialdhyde_dh PF01118.24 ACS99925.1 - 0.019 15.4 0.0 0.042 14.3 0.0 1.6 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ACS99925.1 - 0.025 15.1 0.0 0.075 13.6 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.25 ACS99925.1 - 0.058 12.8 0.6 0.48 9.9 0.6 2.1 1 1 0 1 1 1 0 short chain dehydrogenase NmrA PF05368.13 ACS99925.1 - 0.073 12.6 0.0 0.29 10.6 0.0 2.0 3 0 0 3 3 3 0 NmrA-like family Glyco_transf_4 PF13439.6 ACS99925.1 - 0.081 12.9 0.1 0.18 11.8 0.1 1.7 1 1 0 1 1 1 0 Glycosyltransferase Family 4 DFP PF04127.15 ACS99925.1 - 0.086 12.7 0.0 0.21 11.4 0.0 1.6 1 1 1 2 2 2 0 DNA / pantothenate metabolism flavoprotein F420_oxidored PF03807.17 ACS99925.1 - 0.17 12.4 0.2 0.89 10.2 0.0 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DUF3357 PF11837.8 ACS99926.1 - 0.016 15.6 0.2 0.024 15.1 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Menin PF05053.13 ACS99926.1 - 6.9 4.9 6.5 7.7 4.7 6.5 1.0 1 0 0 1 1 1 0 Menin DUF2621 PF11084.8 ACS99927.1 - 3.4e-68 227.9 0.0 3.8e-68 227.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2621) PCP_red PF08369.10 ACS99927.1 - 0.15 12.3 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit AP_endonuc_2 PF01261.24 ACS99928.1 - 6.4e-37 127.0 0.1 8.3e-37 126.7 0.1 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel PRMT5_TIM PF17285.2 ACS99928.1 - 0.0085 15.3 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain DUF570 PF04489.13 ACS99928.1 - 0.081 11.5 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF570) Formyl_trans_N PF00551.19 ACS99929.1 - 4.3e-41 140.6 0.1 5.5e-41 140.3 0.1 1.1 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.25 ACS99929.1 - 6.7e-10 38.6 0.0 1.6e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 ACS99929.1 - 0.0015 18.5 0.0 0.0036 17.2 0.0 1.8 1 1 0 1 1 1 1 ACT domain Transketolase_N PF00456.21 ACS99930.1 - 7.6e-151 501.8 0.1 1e-150 501.3 0.1 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ACS99930.1 - 2.3e-47 160.9 1.6 8.5e-47 159.1 0.0 2.5 3 0 0 3 3 3 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ACS99930.1 - 1e-11 44.8 0.0 4e-11 42.9 0.0 2.1 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 ACS99930.1 - 1e-06 28.0 0.1 1.7e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 ACS99930.1 - 1.7e-05 24.2 0.1 0.0026 17.0 0.2 2.4 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 ACS99930.1 - 7e-05 22.7 1.7 0.007 16.2 1.7 2.8 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF3343 PF11823.8 ACS99930.1 - 0.065 12.7 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3343) DUF515 PF04415.12 ACS99930.1 - 0.068 11.6 0.0 0.11 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Ppnp PF06865.11 ACS99931.1 - 7.4e-37 125.7 0.0 8.6e-37 125.4 0.0 1.0 1 0 0 1 1 1 1 Pyrimidine/purine nucleoside phosphorylase NAD_binding_2 PF03446.15 ACS99932.1 - 2.5e-48 164.2 1.0 3.7e-48 163.7 1.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ACS99932.1 - 2.2e-28 98.9 1.8 3.5e-28 98.3 1.8 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 ACS99932.1 - 6.3e-08 33.1 0.2 1.5e-07 31.9 0.2 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 ACS99932.1 - 1.3e-06 28.1 0.0 2.4e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 ACS99932.1 - 3.4e-05 23.9 0.1 9.7e-05 22.4 0.0 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 ACS99932.1 - 0.00011 22.1 2.5 0.00049 20.0 0.3 2.5 2 1 1 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ACS99932.1 - 0.00096 18.6 0.3 0.0027 17.1 0.1 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ACS99932.1 - 0.051 14.0 0.0 0.14 12.6 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding PGI PF00342.19 ACS99933.1 - 4.3e-24 85.0 0.0 2.5e-23 82.4 0.0 1.8 1 1 0 1 1 1 1 Phosphoglucose isomerase EIIA-man PF03610.16 ACS99933.1 - 0.17 12.1 0.0 0.42 10.8 0.0 1.7 1 1 0 1 1 1 0 PTS system fructose IIA component UPF0029 PF01205.19 ACS99934.1 - 3.1e-33 114.2 0.0 5.1e-33 113.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 DUF1949 PF09186.11 ACS99934.1 - 7.1e-14 51.4 0.0 1.2e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1949) BPD_transp_1 PF00528.22 ACS99935.1 - 1.9e-23 83.2 15.8 1.9e-23 83.2 15.8 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component EXS PF03124.14 ACS99935.1 - 0.17 11.2 6.7 0.3 10.4 0.0 2.8 2 1 1 3 3 3 0 EXS family BPD_transp_1 PF00528.22 ACS99936.1 - 1.3e-14 54.4 13.6 1.3e-14 54.4 13.6 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Oxidored_q2 PF00420.24 ACS99936.1 - 0.77 9.4 7.4 0.86 9.3 1.1 2.8 3 1 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L ABC_tran PF00005.27 ACS99937.1 - 6.7e-35 120.6 0.0 1.2e-34 119.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter TOBE_2 PF08402.10 ACS99937.1 - 1.2e-08 34.9 0.1 6.1e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 TOBE domain AAA_21 PF13304.6 ACS99937.1 - 3.1e-08 33.8 0.3 0.0023 17.8 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACS99937.1 - 0.0018 17.8 0.1 0.014 14.9 0.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ACS99937.1 - 0.0054 16.9 0.2 0.076 13.3 0.2 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 ACS99937.1 - 0.035 14.6 0.2 0.064 13.8 0.2 1.5 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACS99937.1 - 0.038 13.9 0.0 0.082 12.8 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA PF00004.29 ACS99937.1 - 0.047 14.1 0.1 0.44 11.0 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TOBE PF03459.17 ACS99937.1 - 0.048 14.0 0.1 0.094 13.0 0.1 1.4 1 0 0 1 1 1 0 TOBE domain AAA_28 PF13521.6 ACS99937.1 - 0.059 13.6 0.1 0.33 11.2 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ACS99937.1 - 0.14 12.7 0.0 0.36 11.4 0.0 1.7 1 1 1 2 2 2 0 AAA domain Adeno_IVa2 PF02456.15 ACS99937.1 - 0.17 10.7 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_16 PF13191.6 ACS99937.1 - 0.17 12.2 0.2 0.46 10.9 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain SBP_bac_11 PF13531.6 ACS99938.1 - 1.5e-42 145.9 0.0 2e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACS99938.1 - 1.3e-13 51.6 5.1 2e-13 51.0 5.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACS99938.1 - 4.9e-07 29.8 1.1 1.2e-06 28.6 0.1 1.8 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACS99938.1 - 2e-06 27.4 0.1 3.4e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Phosphonate-bd PF12974.7 ACS99938.1 - 3.9e-05 23.4 0.0 5.8e-05 22.8 0.0 1.3 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein YHYH PF14240.6 ACS99938.1 - 0.085 12.8 0.1 0.18 11.7 0.0 1.6 2 0 0 2 2 2 0 YHYH protein Hydrolase_3 PF08282.12 ACS99939.1 - 5.2e-69 232.8 1.0 5.8e-69 232.7 1.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ACS99939.1 - 8.3e-16 58.3 0.0 2.4e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 ACS99939.1 - 1.6e-05 25.3 2.3 0.0003 21.2 2.3 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ACS99939.1 - 0.014 15.5 1.7 1.3 9.1 0.0 2.6 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Phage-tail_2 PF09096.10 ACS99939.1 - 0.039 13.9 0.0 0.071 13.1 0.0 1.5 1 0 0 1 1 1 0 Baseplate structural protein, domain 2 HAD PF12710.7 ACS99939.1 - 0.046 14.1 1.5 12 6.3 0.0 2.9 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Peptidase_S41 PF03572.18 ACS99940.1 - 1.4e-47 161.4 0.3 2e-47 160.8 0.3 1.3 1 0 0 1 1 1 1 Peptidase family S41 PDZ_2 PF13180.6 ACS99940.1 - 2.2e-13 50.3 1.8 4e-13 49.5 0.7 2.0 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 ACS99940.1 - 1.9e-12 46.8 1.9 2.4e-12 46.5 0.5 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 ACS99940.1 - 6e-12 45.7 1.0 1.6e-11 44.4 0.3 2.1 2 0 0 2 2 2 1 PDZ domain PG_binding_1 PF01471.18 ACS99940.1 - 2e-09 37.5 0.3 2e-09 37.5 0.3 2.2 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Tricorn_PDZ PF14685.6 ACS99940.1 - 0.00065 19.6 1.2 0.0031 17.5 0.2 2.4 2 0 0 2 2 2 1 Tricorn protease PDZ domain DUF3394 PF11874.8 ACS99940.1 - 0.0092 15.7 0.0 0.029 14.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3394) TOBE_3 PF12857.7 ACS99940.1 - 0.061 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 TOBE-like domain PG_binding_2 PF08823.11 ACS99940.1 - 0.11 12.8 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 Putative peptidoglycan binding domain DUF1450 PF07293.11 ACS99941.1 - 7.4e-15 54.5 0.1 7.7e-15 54.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1450) Ferritin PF00210.24 ACS99942.1 - 3.1e-37 127.7 5.7 3.5e-37 127.5 5.7 1.0 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 ACS99942.1 - 0.0043 17.5 4.0 0.015 15.7 3.9 1.8 1 1 1 2 2 2 1 Rubrerythrin UvrD-helicase PF00580.21 ACS99943.1 - 2.9e-58 197.9 13.2 1.9e-34 119.6 7.7 3.0 2 2 2 4 4 4 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ACS99943.1 - 1.8e-43 149.3 0.1 4.9e-43 147.8 0.1 1.7 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ACS99943.1 - 7e-31 107.5 0.1 2.6e-30 105.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 ACS99943.1 - 9.5e-13 47.8 0.1 4.3e-05 23.2 0.0 2.7 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 ACS99943.1 - 5.7e-05 22.9 0.3 0.017 14.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 ACS99943.1 - 0.0023 17.6 0.1 0.05 13.2 0.0 2.7 3 0 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 ACS99943.1 - 0.0047 16.7 0.2 5.6 6.6 0.0 4.0 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 ACS99943.1 - 0.13 12.1 1.9 0.32 10.7 0.0 2.5 3 0 0 3 3 3 0 AAA domain SPATA6 PF14909.6 ACS99943.1 - 0.32 11.1 1.4 0.76 9.9 1.2 1.7 2 0 0 2 2 2 0 Spermatogenesis-assoc protein 6 Acetyltransf_1 PF00583.25 ACS99944.1 - 2.5e-13 50.3 0.1 3.2e-13 49.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACS99944.1 - 5e-12 45.9 0.1 7.9e-12 45.2 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACS99944.1 - 4.4e-10 39.8 0.2 6.5e-10 39.3 0.2 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACS99944.1 - 3.1e-07 30.3 0.0 5.3e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ACS99944.1 - 8.6e-05 22.6 0.1 0.00032 20.8 0.0 1.9 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACS99944.1 - 0.00025 21.1 0.0 0.00055 20.0 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 ACS99944.1 - 0.0075 17.0 0.0 0.015 16.0 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 ACS99944.1 - 0.023 14.3 0.0 0.056 13.0 0.0 1.6 2 0 0 2 2 2 0 GNAT acetyltransferase Acetyltransf_13 PF13880.6 ACS99944.1 - 0.034 14.1 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_1 PF00583.25 ACS99945.1 - 1.1e-07 32.1 0.0 1.3e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACS99945.1 - 1.7e-06 28.3 0.0 2.1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACS99945.1 - 7.6e-06 25.9 0.0 9.1e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACS99945.1 - 1.3e-05 25.9 0.0 1.4e-05 25.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACS99945.1 - 0.00019 21.4 0.0 0.00027 20.8 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein FUR PF01475.19 ACS99946.1 - 5e-40 136.4 0.1 6.6e-40 136.0 0.1 1.2 1 0 0 1 1 1 1 Ferric uptake regulator family TF_Zn_Ribbon PF08271.12 ACS99946.1 - 0.0032 16.9 0.5 0.13 11.8 0.1 2.3 2 0 0 2 2 2 1 TFIIB zinc-binding LIM PF00412.22 ACS99946.1 - 0.053 13.8 1.7 0.17 12.2 0.2 2.1 2 0 0 2 2 2 0 LIM domain zf-RRN7 PF11781.8 ACS99946.1 - 0.26 11.0 2.1 0.65 9.7 0.5 2.2 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DUF1904 PF08921.11 ACS99947.1 - 4.6e-25 88.0 0.0 5.2e-25 87.9 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1904) SQHop_cyclase_C PF13243.6 ACS99948.1 - 1.5e-81 274.0 2.3 5e-79 265.7 5.3 2.7 3 0 0 3 3 3 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 ACS99948.1 - 4e-55 187.0 2.2 1.7e-48 165.2 0.0 4.4 3 1 0 4 4 4 2 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 ACS99948.1 - 1.7e-21 75.7 10.2 4.2e-08 32.8 0.0 7.1 7 0 0 7 7 7 5 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 ACS99948.1 - 0.00084 18.8 0.0 2.2 7.5 0.0 3.0 3 1 0 3 3 3 2 Pectic acid lyase TED_complement PF07678.14 ACS99948.1 - 0.0041 16.2 2.1 5.7 5.9 0.0 4.0 3 1 0 4 4 4 2 A-macroglobulin TED domain PseudoU_synth_2 PF00849.22 ACS99951.1 - 8.6e-31 107.2 0.5 1.4e-30 106.5 0.5 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 ACS99951.1 - 2e-05 24.2 0.0 4.8e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 ACS99951.1 - 0.0054 16.5 0.4 0.013 15.3 0.1 1.8 2 0 0 2 2 2 1 S4 domain AbiEi_2 PF09952.9 ACS99951.1 - 0.12 12.6 0.1 0.2 11.9 0.1 1.3 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system Cu_amine_oxidN1 PF07833.11 ACS99952.1 - 5.6e-31 106.9 3.5 7.9e-31 106.4 0.7 2.5 2 1 0 2 2 2 1 Copper amine oxidase N-terminal domain Trypsin_2 PF13365.6 ACS99952.1 - 5.2e-26 92.3 2.3 1.2e-25 91.2 2.3 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 ACS99952.1 - 3.2e-12 46.8 2.2 7e-12 45.6 2.2 1.5 1 0 0 1 1 1 1 Trypsin DUF4080 PF13311.6 ACS99953.1 - 1.5e-46 159.0 2.8 1.6e-46 158.9 1.6 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF4080) B12-binding PF02310.19 ACS99953.1 - 1.1e-19 70.6 0.0 2e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain Radical_SAM PF04055.21 ACS99953.1 - 3.6e-17 63.2 0.3 3.7e-15 56.7 0.1 2.5 2 1 0 2 2 2 2 Radical SAM superfamily dNK PF01712.19 ACS99954.1 - 1.5e-62 211.1 0.0 1.7e-62 210.9 0.0 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 ACS99954.1 - 7e-08 33.1 0.0 1.2e-07 32.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ACS99954.1 - 2.9e-05 24.4 0.5 6.1e-05 23.3 0.5 1.7 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 ACS99954.1 - 0.00033 20.4 0.0 0.025 14.2 0.0 2.3 2 0 0 2 2 2 1 Thymidylate kinase AAA_33 PF13671.6 ACS99954.1 - 0.0025 18.0 0.2 0.06 13.5 0.2 2.2 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 ACS99954.1 - 0.0051 17.0 0.2 0.014 15.5 0.1 1.7 2 0 0 2 2 2 1 Cytidylate kinase-like family TsaE PF02367.17 ACS99954.1 - 0.006 16.6 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE SKI PF01202.22 ACS99954.1 - 0.0079 16.3 0.1 0.42 10.7 0.1 2.6 2 1 0 2 2 2 1 Shikimate kinase AAA_25 PF13481.6 ACS99954.1 - 0.012 15.2 0.2 0.029 14.0 0.1 1.6 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ACS99954.1 - 0.018 14.9 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ACS99954.1 - 0.032 14.5 0.1 0.056 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACS99954.1 - 0.039 14.0 0.0 0.072 13.2 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 ACS99954.1 - 0.057 13.9 0.0 0.08 13.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Cytidylate_kin PF02224.18 ACS99954.1 - 0.063 13.0 0.0 0.25 11.0 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase AAA_16 PF13191.6 ACS99954.1 - 0.083 13.3 0.1 0.19 12.1 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 ACS99954.1 - 0.09 13.2 0.0 1.6 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ACS99954.1 - 0.12 12.8 0.0 0.4 11.1 0.0 1.9 3 0 0 3 3 1 0 RNA helicase AAA_29 PF13555.6 ACS99954.1 - 0.14 12.0 0.1 0.31 10.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 ACS99954.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 ACS99954.1 - 0.16 11.5 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MFS_1 PF07690.16 ACS99955.1 - 7.3e-28 97.5 68.0 8.6e-25 87.4 36.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily NDUF_B12 PF08122.12 ACS99955.1 - 0.13 12.3 2.5 0.83 9.7 0.1 3.1 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family ROK PF00480.20 ACS99956.1 - 2.9e-19 69.6 0.3 1.6e-17 64.0 0.0 2.2 1 1 0 2 2 2 1 ROK family HTH_24 PF13412.6 ACS99956.1 - 0.0031 17.0 0.0 0.0066 16.0 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 ACS99956.1 - 0.005 16.7 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family TrmB PF01978.19 ACS99956.1 - 0.0098 15.8 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 ACS99956.1 - 0.047 13.6 0.1 0.092 12.7 0.1 1.4 1 0 0 1 1 1 0 MarR family HTH_Crp_2 PF13545.6 ACS99956.1 - 0.056 13.4 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_Mga PF08280.11 ACS99956.1 - 0.15 12.1 0.3 8.9 6.4 0.0 2.5 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain Fe_dep_repress PF01325.19 ACS99956.1 - 0.17 12.1 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain rRNA_methylase PF06962.12 ACS99957.1 - 6.1e-40 136.4 0.0 7.9e-40 136.0 0.0 1.1 1 0 0 1 1 1 1 Putative rRNA methylase Methyltransf_31 PF13847.6 ACS99957.1 - 5.3e-05 23.1 0.0 9.6e-05 22.2 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACS99957.1 - 0.00033 21.3 0.0 0.00053 20.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_5 PF01795.19 ACS99957.1 - 0.00039 20.0 0.0 0.00066 19.3 0.0 1.3 2 0 0 2 2 2 1 MraW methylase family Ubie_methyltran PF01209.18 ACS99957.1 - 0.0017 17.8 0.0 0.0026 17.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltr_RsmB-F PF01189.17 ACS99957.1 - 0.0021 17.7 0.0 0.0068 16.1 0.0 1.7 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 ACS99957.1 - 0.027 14.2 0.0 0.039 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 ACS99957.1 - 0.12 12.1 0.0 0.4 10.4 0.0 1.8 1 1 0 1 1 1 0 Met-10+ like-protein PrmA PF06325.13 ACS99957.1 - 0.14 11.6 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Radical_SAM_C PF16199.5 ACS99958.1 - 6.3e-25 87.0 0.2 1.2e-24 86.2 0.2 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 ACS99958.1 - 5.7e-15 56.1 0.1 1.2e-14 55.1 0.1 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Methyltransf_4 PF02390.17 ACS99960.1 - 1.4e-42 145.1 0.0 1.7e-42 144.8 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 ACS99960.1 - 0.00031 21.4 0.0 0.00074 20.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACS99960.1 - 0.0046 16.8 0.0 0.029 14.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACS99960.1 - 0.0053 16.6 0.0 0.014 15.2 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACS99960.1 - 0.034 14.8 0.0 0.059 14.0 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 ACS99960.1 - 0.056 14.2 0.0 0.23 12.2 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain PAP2 PF01569.21 ACS99961.1 - 4.2e-19 68.7 3.4 4.2e-19 68.7 3.4 1.8 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 ACS99961.1 - 5.1e-09 36.1 6.9 7e-09 35.6 6.9 1.3 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 ACS99961.1 - 0.01 16.3 0.7 0.01 16.3 0.7 2.2 2 1 0 2 2 2 0 PAP2 superfamily C-terminal Glycos_transf_1 PF00534.20 ACS99962.1 - 2.8e-43 147.4 0.0 3.8e-43 147.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACS99962.1 - 2e-34 118.9 0.0 3.1e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACS99962.1 - 4.2e-33 114.7 0.1 1.7e-32 112.7 0.1 2.0 3 0 0 3 3 3 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACS99962.1 - 1.9e-13 51.1 0.0 7.2e-13 49.3 0.0 2.0 3 0 0 3 3 3 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ACS99962.1 - 8.5e-11 42.1 0.0 1.6e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 ACS99962.1 - 1e-07 32.1 0.0 1.7e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like RMMBL PF07521.12 ACS99962.1 - 0.096 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Glyco_tranf_2_3 PF13641.6 ACS99963.1 - 1.1e-28 100.7 0.0 1.5e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ACS99963.1 - 2.7e-17 63.4 4.5 5.5e-17 62.3 4.5 1.6 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ACS99963.1 - 1.8e-12 47.4 0.0 3.1e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ACS99963.1 - 7.6e-08 32.0 0.0 1.2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 ACS99963.1 - 1.2e-06 28.9 0.1 2.2e-06 28.1 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Anp1 PF03452.14 ACS99963.1 - 0.0046 16.4 0.0 0.0067 15.9 0.0 1.2 1 0 0 1 1 1 1 Anp1 Chitin_synth_2 PF03142.15 ACS99963.1 - 0.032 12.9 0.1 0.38 9.3 0.0 2.3 2 1 0 3 3 3 0 Chitin synthase IF3_C PF00707.22 ACS99964.1 - 8e-37 125.1 0.1 1.3e-36 124.4 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 ACS99964.1 - 6.6e-34 116.0 0.2 1.1e-33 115.2 0.2 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain Bact_lectin PF18483.1 ACS99964.1 - 0.078 13.0 0.0 0.092 12.8 0.0 1.1 1 0 0 1 1 1 0 Bacterial lectin Ribosomal_L35p PF01632.19 ACS99965.1 - 3.6e-22 78.6 2.7 3.9e-22 78.5 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L35 Ribosomal_L20 PF00453.18 ACS99966.1 - 6.3e-47 158.1 5.5 7.3e-47 157.9 5.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L20 HTH_18 PF12833.7 ACS99967.1 - 1.7e-19 69.9 1.5 2.9e-19 69.1 1.5 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99967.1 - 3e-16 59.0 0.1 1.6e-07 31.2 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACS99967.1 - 1.4e-09 37.9 0.2 2.8e-09 37.0 0.2 1.8 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACS99967.1 - 5.2e-05 22.9 0.0 8.4e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Cupin domain HTH_23 PF13384.6 ACS99967.1 - 0.029 14.2 0.2 3.7 7.5 0.1 2.6 2 1 1 3 3 3 0 Homeodomain-like domain AraC_binding_2 PF14525.6 ACS99967.1 - 0.053 13.2 0.0 0.75 9.5 0.0 2.1 2 0 0 2 2 2 0 AraC-binding-like domain Cupin_6 PF12852.7 ACS99967.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Cupin Glyco_hyd_65N_2 PF14498.6 ACS99968.1 - 5e-58 196.7 0.0 7.1e-58 196.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain CBM_35 PF16990.5 ACS99969.1 - 1.1e-14 54.7 1.8 1e-06 29.0 0.1 3.3 2 1 1 3 3 3 2 Carbohydrate binding module (family 35) DUF5010_C PF18099.1 ACS99969.1 - 2.4e-09 37.3 0.3 0.0016 18.6 0.0 2.8 2 0 0 2 2 2 2 DUF5010 C-terminal domain Melibiase_C PF17801.1 ACS99969.1 - 1.2e-07 31.7 0.5 7.9e-07 29.1 0.5 2.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain CBM_6 PF03422.15 ACS99969.1 - 2.1e-06 28.1 4.0 9.8e-05 22.7 0.4 5.6 6 1 1 7 7 7 2 Carbohydrate binding module (family 6) Ig_6 PF18452.1 ACS99969.1 - 0.014 14.9 0.0 6.5 6.4 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain His_kinase PF06580.13 ACS99970.1 - 2.7e-24 85.3 1.6 2.7e-24 85.3 1.6 2.2 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACS99970.1 - 5.8e-18 65.6 3.9 5.8e-18 65.6 3.9 1.5 2 0 0 2 2 2 1 Cache domain HAMP PF00672.25 ACS99970.1 - 3e-07 30.7 0.7 5.9e-07 29.8 0.7 1.5 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACS99970.1 - 0.0019 18.7 0.0 0.0043 17.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MIS13 PF08202.11 ACS99970.1 - 0.086 12.1 0.8 9.4 5.4 0.1 2.3 2 0 0 2 2 2 0 Mis12-Mtw1 protein family EF-hand_14 PF17959.1 ACS99970.1 - 0.11 12.9 0.0 0.65 10.4 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain Response_reg PF00072.24 ACS99971.1 - 2.7e-26 91.9 0.1 6.3e-26 90.8 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACS99971.1 - 3.3e-19 68.5 0.0 7.8e-09 35.4 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACS99971.1 - 2.3e-18 66.2 0.0 2.3e-18 66.2 0.0 2.7 4 0 0 4 4 4 1 Helix-turn-helix domain GGDEF_2 PF17853.1 ACS99971.1 - 0.00079 19.7 0.1 0.0032 17.7 0.1 2.0 1 0 0 1 1 1 1 GGDEF-like domain DUF410 PF04190.13 ACS99971.1 - 0.016 15.1 0.1 0.025 14.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF410) Rrf2 PF02082.20 ACS99971.1 - 0.02 15.2 0.2 0.15 12.4 0.0 2.6 2 1 1 3 3 3 0 Transcriptional regulator Sigma70_ECF PF07638.11 ACS99971.1 - 0.33 10.8 2.6 7.5 6.4 0.0 3.3 4 0 0 4 4 4 0 ECF sigma factor BPD_transp_1 PF00528.22 ACS99972.1 - 6.8e-18 65.0 10.6 6.8e-18 65.0 10.6 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACS99973.1 - 1.5e-12 47.6 17.9 1.5e-12 47.6 17.9 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACS99974.1 - 6.7e-27 95.0 6.3 6.7e-27 95.0 6.3 2.1 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACS99974.1 - 2.1e-19 70.6 11.5 3.2e-19 70.0 11.5 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACS99974.1 - 0.00017 21.1 0.1 0.24 10.8 0.0 2.4 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACS99974.1 - 0.068 12.9 0.0 0.22 11.2 0.0 1.8 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein Melibiase_C PF17801.1 ACS99975.1 - 6e-07 29.4 0.0 1.7e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Lysozyme_like PF13702.6 ACS99975.1 - 0.021 14.5 0.0 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 Lysozyme-like Acetyltransf_1 PF00583.25 ACS99977.1 - 3.5e-11 43.4 0.0 4.2e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACS99977.1 - 9.3e-11 42.0 0.0 1.3e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACS99977.1 - 3.1e-10 40.1 0.0 3.7e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACS99977.1 - 9.2e-06 25.5 0.0 1.5e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ACS99977.1 - 0.05 13.7 0.0 0.079 13.1 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase TPP_enzyme_N PF02776.18 ACS99978.1 - 8.6e-56 188.2 0.5 1.5e-54 184.2 0.0 2.5 2 1 1 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 ACS99978.1 - 6.7e-54 181.8 0.2 2.8e-52 176.6 0.1 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ACS99978.1 - 2.3e-48 163.4 0.0 4.2e-48 162.6 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 ACS99978.1 - 0.009 15.8 0.2 0.019 14.7 0.2 1.5 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg ALS_ss_C PF10369.9 ACS99979.1 - 2.5e-29 101.3 0.6 2.3e-28 98.2 0.1 2.1 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT_5 PF13710.6 ACS99979.1 - 5.5e-18 64.6 0.0 1.1e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT PF01842.25 ACS99979.1 - 1.2e-15 56.9 0.5 4.4e-15 55.1 0.1 1.9 2 0 0 2 2 2 1 ACT domain ACT_4 PF13291.6 ACS99979.1 - 8.6e-06 26.3 0.3 1.9e-05 25.2 0.3 1.5 1 0 0 1 1 1 1 ACT domain DAHP_snth_FXD PF18152.1 ACS99979.1 - 0.0018 18.1 1.0 0.76 9.7 0.0 2.4 2 0 0 2 2 2 2 DAHP synthase ferredoxin-like domain Saccharop_dh_N PF04455.12 ACS99979.1 - 0.024 15.0 0.0 0.045 14.1 0.0 1.5 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region IlvN PF07991.12 ACS99980.1 - 6.4e-78 260.0 1.4 8.8e-78 259.6 1.4 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 ACS99980.1 - 1.1e-66 223.5 0.5 1.7e-66 223.0 0.5 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain 2-Hacid_dh_C PF02826.19 ACS99980.1 - 1.8e-08 34.0 0.1 3.2e-08 33.1 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 ACS99980.1 - 2.1e-07 31.1 0.4 4.5e-07 30.1 0.1 1.7 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_2 PF03446.15 ACS99980.1 - 3.3e-07 30.6 0.1 7.1e-07 29.5 0.1 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACS99980.1 - 5.4e-06 26.9 0.9 9.8e-06 26.1 0.3 1.7 2 0 0 2 2 1 1 NADP oxidoreductase coenzyme F420-dependent CoA_binding PF02629.19 ACS99980.1 - 0.0021 18.7 0.3 0.0048 17.5 0.3 1.6 1 0 0 1 1 1 1 CoA binding domain DUF1103 PF06513.11 ACS99980.1 - 0.009 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Oxidored_nitro PF00148.19 ACS99980.1 - 0.017 13.8 0.1 0.042 12.6 0.0 1.6 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase ApbA PF02558.16 ACS99980.1 - 0.056 13.1 0.2 0.13 11.9 0.2 1.7 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA CoA_binding_2 PF13380.6 ACS99980.1 - 0.065 13.7 0.2 0.2 12.2 0.1 1.8 1 1 1 2 2 2 0 CoA binding domain NAD_binding_7 PF13241.6 ACS99980.1 - 0.083 13.3 0.4 0.55 10.7 0.2 2.4 2 1 0 2 2 2 0 Putative NAD(P)-binding HMGL-like PF00682.19 ACS99981.1 - 2.7e-97 325.5 0.3 4.3e-97 324.8 0.3 1.3 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 ACS99981.1 - 1.4e-38 131.8 2.5 1.4e-38 131.8 2.5 1.7 2 0 0 2 2 2 1 LeuA allosteric (dimerisation) domain EFhand_Ca_insen PF08726.10 ACS99981.1 - 0.13 12.4 1.4 0.26 11.4 0.1 2.1 2 0 0 2 2 2 0 Ca2+ insensitive EF hand UPF0047 PF01894.17 ACS99982.1 - 6.4e-41 139.1 0.0 7.4e-41 138.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 Iso_dh PF00180.20 ACS99983.1 - 2.2e-135 451.3 0.0 2.5e-135 451.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Sec63 PF02889.16 ACS99983.1 - 0.15 11.2 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 Sec63 Brl domain DUF4777 PF16007.5 ACS99983.1 - 0.16 12.3 0.0 3.2 8.1 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4777) AhpC-TSA PF00578.21 ACS99984.1 - 1.3e-39 134.9 0.0 1.6e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ACS99984.1 - 1.1e-17 64.1 0.0 1.3e-17 63.9 0.0 1.0 1 0 0 1 1 1 1 Redoxin SCO1-SenC PF02630.14 ACS99984.1 - 0.014 15.3 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 SCO1/SenC 1-cysPrx_C PF10417.9 ACS99984.1 - 0.028 14.2 0.0 0.063 13.1 0.0 1.6 1 0 0 1 1 1 0 C-terminal domain of 1-Cys peroxiredoxin GerA PF03323.13 ACS99985.1 - 3.4e-93 312.7 5.3 4.1e-93 312.4 5.3 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_permease PF03845.13 ACS99986.1 - 7.2e-23 80.9 34.8 1e-22 80.4 34.8 1.2 1 0 0 1 1 1 1 Spore germination protein ACR_tran PF00873.19 ACS99986.1 - 2.4 5.7 8.4 0.28 8.8 2.9 1.8 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family Spore_GerAC PF05504.11 ACS99987.1 - 7.1e-23 81.6 3.1 1e-22 81.1 3.1 1.2 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal Sigma70_r2 PF04542.14 ACS99989.1 - 4e-09 36.1 0.0 8e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_ECF PF07638.11 ACS99989.1 - 4e-06 26.8 0.4 0.00055 19.9 0.4 2.2 1 1 0 1 1 1 1 ECF sigma factor HTH_DeoR PF08220.12 ACS99989.1 - 0.008 15.9 0.0 0.043 13.6 0.0 2.2 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_23 PF13384.6 ACS99989.1 - 0.026 14.3 0.0 0.076 12.8 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain DUF1804 PF08822.11 ACS99989.1 - 0.039 13.9 0.0 0.17 11.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1804) UPF0175 PF03683.13 ACS99989.1 - 0.046 13.4 1.1 2 8.2 0.0 3.2 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0175) RsgI_N PF12791.7 ACS99990.1 - 4.6e-15 55.3 0.0 9.7e-15 54.2 0.0 1.6 1 0 0 1 1 1 1 Anti-sigma factor N-terminus HATPase_c PF02518.26 ACS99991.1 - 2e-23 83.0 0.1 3.6e-23 82.2 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RsbU_N PF08673.10 ACS99991.1 - 4.5e-20 71.5 0.4 4.5e-20 71.5 0.4 2.0 2 0 0 2 2 2 1 Phosphoserine phosphatase RsbU, N-terminal domain HisKA PF00512.25 ACS99991.1 - 1.3e-13 50.7 0.0 4.2e-13 49.1 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_7 PF12860.7 ACS99991.1 - 5.8e-10 39.4 0.0 2.2e-09 37.5 0.0 2.1 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.6 ACS99991.1 - 1.4e-07 31.4 0.0 4.7e-07 29.7 0.0 1.9 1 1 1 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 ACS99991.1 - 9.9e-06 25.5 0.0 4e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 PAS fold HATPase_c_5 PF14501.6 ACS99991.1 - 6.1e-05 22.9 0.1 0.00018 21.3 0.1 1.8 1 0 0 1 1 1 1 GHKL domain PAS_9 PF13426.7 ACS99991.1 - 0.00012 22.2 0.1 0.001 19.3 0.0 2.5 2 1 0 2 2 2 1 PAS domain Calpain_III PF01067.22 ACS99991.1 - 0.0022 18.3 0.1 0.0099 16.1 0.0 2.0 2 0 0 2 2 2 1 Calpain large subunit, domain III PAS_4 PF08448.10 ACS99991.1 - 0.053 13.8 0.0 0.21 11.9 0.0 2.0 3 0 0 3 3 3 0 PAS fold PG_binding_4 PF12229.8 ACS99991.1 - 0.08 13.2 0.2 0.18 12.1 0.2 1.5 1 0 0 1 1 1 0 Putative peptidoglycan binding domain PAS_8 PF13188.7 ACS99991.1 - 0.12 12.4 0.0 0.35 10.9 0.0 1.8 1 0 0 1 1 1 0 PAS domain CE2_N PF17996.1 ACS99991.1 - 0.18 11.8 0.1 0.36 10.8 0.1 1.4 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal Peptidase_M17 PF00883.21 ACS99992.1 - 3.1e-117 391.3 0.4 4.2e-117 390.9 0.4 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 ACS99992.1 - 1.6e-08 34.4 0.9 3.5e-08 33.3 0.9 1.6 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain Response_reg PF00072.24 ACS99993.1 - 5.7e-27 94.1 0.0 2.1e-26 92.3 0.0 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACS99993.1 - 4.9e-17 62.0 0.0 1.2e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACS99993.1 - 8.5e-11 41.7 0.1 0.00018 21.5 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACS99993.1 - 0.0011 19.2 0.0 0.0024 18.1 0.0 1.7 1 0 0 1 1 1 1 GGDEF-like domain His_kinase PF06580.13 ACS99994.1 - 4.6e-23 81.3 1.9 1.5e-22 79.7 0.2 2.6 2 1 0 2 2 2 1 Histidine kinase HAMP PF00672.25 ACS99994.1 - 2.2e-09 37.5 0.0 4.1e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACS99994.1 - 1.9e-06 28.3 0.1 1.9e-05 25.1 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACS99994.1 - 8.6e-06 25.7 4.9 1.5e-05 24.9 4.9 1.4 1 0 0 1 1 1 1 Cache domain Cyc-maltodext_N PF09087.11 ACS99994.1 - 0.05 13.9 0.3 1.1 9.6 0.0 2.8 2 1 1 3 3 3 0 Cyclomaltodextrinase, N-terminal CECR6_TMEM121 PF14997.6 ACS99994.1 - 0.085 12.7 1.3 0.18 11.6 0.1 1.9 2 0 0 2 2 2 0 CECR6/TMEM121 family Latarcin PF10279.9 ACS99994.1 - 0.11 12.9 0.0 2.6 8.5 0.0 3.1 3 1 0 3 3 3 0 Latarcin precursor HATPase_c_3 PF13589.6 ACS99994.1 - 0.12 12.2 0.1 0.58 10.0 0.0 2.1 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BPD_transp_1 PF00528.22 ACS99996.1 - 1.5e-16 60.7 9.0 1.5e-16 60.7 9.0 2.2 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component MNHE PF01899.16 ACS99996.1 - 0.0066 16.2 1.9 0.0066 16.2 1.9 2.4 3 0 0 3 3 3 1 Na+/H+ ion antiporter subunit NPCC PF08058.11 ACS99996.1 - 0.11 12.5 2.8 0.41 10.7 2.8 1.9 1 0 0 1 1 1 0 Nuclear pore complex component BPD_transp_1 PF00528.22 ACS99997.1 - 1.6e-09 37.8 24.3 2.5e-08 33.9 24.3 2.3 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Glyco_hydro_67M PF07488.12 ACS99998.1 - 1.7e-159 530.1 0.0 2.5e-159 529.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 middle domain Glyco_hydro_67C PF07477.12 ACS99998.1 - 4e-95 317.6 3.9 6.3e-95 316.9 3.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 C-terminus Glyco_hydro_67N PF03648.14 ACS99998.1 - 4.9e-20 72.0 0.0 9.9e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus DUF4838 PF16126.5 ACS99998.1 - 0.0061 16.0 0.1 0.011 15.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4838) Glyco_hydro_10 PF00331.20 ACS99999.1 - 2.1e-111 372.1 1.7 2.4e-111 371.9 1.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 AP_endonuc_2 PF01261.24 ACS99999.1 - 0.0064 15.9 0.2 0.064 12.7 0.0 2.1 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel GYF_2 PF14237.6 ACS99999.1 - 0.041 13.7 0.2 0.46 10.3 0.0 2.5 2 0 0 2 2 2 0 GYF domain 2 Glyco_hydro_43 PF04616.14 ACT00001.1 - 4.2e-87 292.1 0.1 5.4e-87 291.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 ACT00001.1 - 1.7e-35 122.6 0.0 2.2e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF1349 PF07081.11 ACT00001.1 - 0.047 13.4 0.0 0.073 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1349) Oxidored_FMN PF00724.20 ACT00002.1 - 5.4e-89 298.8 0.0 6.2e-89 298.6 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DHO_dh PF01180.21 ACT00002.1 - 3.2e-07 29.9 0.0 5.3e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Dus PF01207.17 ACT00002.1 - 0.0066 15.6 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ACT00002.1 - 0.046 13.2 0.0 0.073 12.5 0.0 1.2 1 0 0 1 1 1 0 Histidine biosynthesis protein DNA_alkylation PF08713.11 ACT00003.1 - 1.4e-18 67.4 0.1 1.8e-18 67.1 0.1 1.1 1 0 0 1 1 1 1 DNA alkylation repair enzyme DUF5112 PF17139.4 ACT00003.1 - 0.059 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5112) MFS_1 PF07690.16 ACT00004.1 - 1.1e-38 133.1 56.9 8.5e-33 113.7 48.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ACT00004.1 - 0.092 12.0 35.2 0.12 11.7 35.2 1.1 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB HTH_18 PF12833.7 ACT00006.1 - 7.2e-18 64.6 0.0 1.3e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00006.1 - 7.3e-13 48.3 0.0 1.5e-06 28.2 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT00006.1 - 1.2e-11 44.6 0.0 2.1e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT00006.1 - 7.6e-07 28.8 0.0 1.2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Cupin domain DMA PF03474.14 ACT00006.1 - 0.17 11.5 0.1 0.74 9.5 0.0 1.9 2 0 0 2 2 2 0 DMRTA motif DUF1179 PF06678.11 ACT00007.1 - 0.05 13.6 0.0 0.12 12.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) SCF PF02404.15 ACT00007.1 - 0.056 12.8 0.0 0.066 12.5 0.0 1.2 1 0 0 1 1 1 0 Stem cell factor DUF5061 PF16587.5 ACT00007.1 - 0.19 11.8 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 17 kDa common-antigen outer membrane protein DJ-1_PfpI PF01965.24 ACT00008.1 - 9.8e-34 116.5 0.0 1.2e-33 116.3 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ACT00008.1 - 0.0089 15.7 0.0 0.023 14.4 0.0 1.6 1 1 0 1 1 1 1 ThiJ/PfpI family-like Peptidase_C26 PF07722.13 ACT00008.1 - 0.045 13.5 0.0 0.071 12.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase C26 GATase PF00117.28 ACT00008.1 - 0.047 13.4 0.0 0.064 13.0 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I GATase_3 PF07685.14 ACT00008.1 - 0.18 11.4 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain His_kinase PF06580.13 ACT00009.1 - 7.3e-22 77.5 1.8 2e-21 76.1 1.8 1.8 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT00009.1 - 1.9e-10 41.0 3.6 3.9e-10 39.9 3.6 1.5 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT00009.1 - 5.2e-07 30.2 0.2 2.8e-06 27.8 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT00009.1 - 0.00011 22.5 0.0 0.00027 21.2 0.0 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c_5 PF14501.6 ACT00009.1 - 0.00069 19.5 3.9 0.00093 19.1 0.4 2.4 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.6 ACT00009.1 - 0.004 17.1 0.0 0.0071 16.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain Response_reg PF00072.24 ACT00010.1 - 9.3e-26 90.2 0.4 1.9e-25 89.2 0.4 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00010.1 - 7.4e-20 71.0 0.0 1.8e-19 69.8 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00010.1 - 3.2e-17 62.2 0.2 4.1e-09 36.3 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_23 PF13384.6 ACT00010.1 - 0.15 11.9 0.0 1 9.2 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain BPD_transp_1 PF00528.22 ACT00011.1 - 1.2e-17 64.3 12.5 1.2e-17 64.3 12.5 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF4293 PF14126.6 ACT00011.1 - 2.2 8.5 10.4 0.16 12.2 2.8 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4293) DUF2207 PF09972.9 ACT00011.1 - 8.7 5.0 10.0 6.5 5.4 5.2 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) BPD_transp_1 PF00528.22 ACT00012.1 - 6.9e-19 68.3 13.3 6.9e-19 68.3 13.3 1.9 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2583 PF10762.9 ACT00012.1 - 0.23 11.9 2.1 0.4 11.1 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2583) AGTRAP PF06396.11 ACT00012.1 - 0.64 9.8 4.5 2.3 8.0 0.2 2.6 3 0 0 3 3 3 0 Angiotensin II, type I receptor-associated protein (AGTRAP) Glyco_hydro_32N PF00251.20 ACT00014.1 - 8.1e-74 248.9 0.1 9.7e-74 248.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 ACT00014.1 - 5.7e-29 101.1 0.0 8e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal DUF4975 PF16346.5 ACT00014.1 - 0.093 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4975) Asp_Glu_race PF01177.22 ACT00015.1 - 4.4e-07 30.0 0.2 5.2e-07 29.7 0.2 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase ACT_6 PF13740.6 ACT00015.1 - 0.0044 17.0 0.0 0.0093 15.9 0.0 1.5 1 0 0 1 1 1 1 ACT domain Sugar_tr PF00083.24 ACT00016.1 - 1.8e-133 445.7 25.7 2.1e-133 445.5 25.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ACT00016.1 - 3.6e-45 154.4 37.9 3.5e-43 147.9 32.5 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ACT00016.1 - 6e-07 28.4 35.5 8.3e-05 21.3 11.6 4.0 2 2 2 4 4 4 3 MFS/sugar transport protein TRI12 PF06609.13 ACT00016.1 - 9.3e-06 24.3 3.6 9.3e-06 24.3 3.6 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF5413 PF17434.2 ACT00016.1 - 0.013 15.8 0.3 0.013 15.8 0.3 2.8 2 1 0 2 2 2 0 Family of unknown function (DUF5413) MFS_3 PF05977.13 ACT00016.1 - 0.014 13.9 18.8 0.057 11.8 7.7 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector DUF3767 PF12597.8 ACT00016.1 - 0.23 11.3 1.6 0.73 9.7 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3767) MFS_1_like PF12832.7 ACT00016.1 - 2.3 7.0 25.7 0.047 12.6 2.1 3.0 3 1 0 3 3 3 0 MFS_1 like family HTH_AraC PF00165.23 ACT00017.1 - 5.4e-24 83.7 0.0 5.8e-12 45.4 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Response_reg PF00072.24 ACT00017.1 - 1.1e-23 83.6 0.2 3.1e-23 82.1 0.0 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00017.1 - 1.2e-21 76.7 0.0 2.9e-21 75.5 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain GGDEF_2 PF17853.1 ACT00017.1 - 1.6e-09 38.0 0.0 9.7e-09 35.5 0.0 2.2 2 0 0 2 2 2 1 GGDEF-like domain His_kinase PF06580.13 ACT00018.1 - 4.6e-26 91.0 2.6 1.4e-25 89.4 0.5 2.8 2 1 0 2 2 2 1 Histidine kinase HAMP PF00672.25 ACT00018.1 - 3.5e-14 52.9 0.2 2.4e-13 50.2 0.0 2.5 2 0 0 2 2 2 1 HAMP domain HATPase_c PF02518.26 ACT00018.1 - 1.1e-06 29.2 0.0 2.4e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT00018.1 - 0.00058 19.7 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IES5 PF17335.2 ACT00018.1 - 0.0061 16.8 0.4 0.078 13.2 0.1 2.5 2 0 0 2 2 2 1 Ino80 complex subunit 5 4HB_MCP_1 PF12729.7 ACT00018.1 - 0.012 15.2 0.5 0.034 13.7 0.1 2.0 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction HATPase_c_2 PF13581.6 ACT00018.1 - 0.046 13.7 0.0 0.099 12.6 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Stimulus_sens_1 PF13756.6 ACT00018.1 - 0.07 13.7 2.7 0.48 11.0 0.7 2.4 2 0 0 2 2 2 0 Stimulus-sensing domain Peripla_BP_4 PF13407.6 ACT00019.1 - 4.7e-51 173.8 2.6 5.4e-51 173.6 2.6 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACT00019.1 - 8.5e-16 58.2 0.5 1e-15 57.9 0.5 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 ACT00019.1 - 5.3e-06 26.9 0.0 1.8e-05 25.2 0.0 1.8 2 1 0 2 2 2 1 Periplasmic binding protein-like domain HGD-D PF06050.13 ACT00019.1 - 0.0013 18.6 0.0 0.0016 18.3 0.0 1.4 1 1 0 1 1 1 1 2-hydroxyglutaryl-CoA dehydratase, D-component Peripla_BP_6 PF13458.6 ACT00019.1 - 0.0058 16.3 0.0 0.14 11.8 0.0 2.2 1 1 1 2 2 2 2 Periplasmic binding protein PucR PF07905.11 ACT00019.1 - 0.0072 16.6 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 Purine catabolism regulatory protein-like family ABC_sub_bind PF04392.12 ACT00019.1 - 0.046 13.0 0.7 1.4 8.1 0.0 2.4 2 1 0 2 2 2 0 ABC transporter substrate binding protein DRTGG PF07085.12 ACT00019.1 - 0.05 13.4 0.0 0.22 11.3 0.0 1.9 2 0 0 2 2 2 0 DRTGG domain Hpr_kinase_N PF02603.16 ACT00019.1 - 0.077 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 HPr Serine kinase N terminus PAS PF00989.25 ACT00020.1 - 9.7e-38 128.7 0.0 1.9e-14 53.6 0.0 3.4 3 0 0 3 3 3 3 PAS fold PAS_9 PF13426.7 ACT00020.1 - 5.3e-33 113.4 0.1 6.3e-13 48.9 0.0 3.4 3 0 0 3 3 3 3 PAS domain PAS_4 PF08448.10 ACT00020.1 - 3.8e-31 107.6 0.0 1.9e-14 53.9 0.0 3.2 3 0 0 3 3 3 3 PAS fold HATPase_c PF02518.26 ACT00020.1 - 9.8e-23 80.8 0.4 2.3e-22 79.6 0.4 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_8 PF13188.7 ACT00020.1 - 2.8e-21 75.1 0.4 8e-08 32.1 0.0 3.5 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 ACT00020.1 - 5.6e-15 55.4 0.0 0.00059 20.1 0.0 3.4 3 0 0 3 3 3 3 PAS fold HisKA PF00512.25 ACT00020.1 - 2.4e-14 53.1 0.0 9.1e-14 51.2 0.0 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 ACT00020.1 - 8.4e-05 22.4 0.1 0.00022 21.1 0.1 1.7 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 ACT00020.1 - 0.00074 19.5 0.0 0.0032 17.4 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain PAS_7 PF12860.7 ACT00020.1 - 0.0088 16.2 0.1 0.22 11.7 0.0 3.2 2 1 0 2 2 2 1 PAS fold HATPase_c_3 PF13589.6 ACT00020.1 - 0.031 14.1 0.0 0.069 13.0 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HPTransfase PF10090.9 ACT00020.1 - 0.035 13.9 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 Histidine phosphotransferase C-terminal domain PAS_12 PF18095.1 ACT00020.1 - 0.072 12.7 0.0 0.72 9.5 0.0 2.4 3 0 0 3 3 3 0 UPF0242 C-terminal PAS-like domain Peripla_BP_3 PF13377.6 ACT00021.1 - 3.6e-32 112.0 0.0 7.6e-32 110.9 0.0 1.5 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT00021.1 - 3e-25 89.2 0.0 4.1e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT00021.1 - 5e-23 80.6 2.0 1e-22 79.6 2.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACT00021.1 - 1.5e-21 77.1 0.0 3.8e-21 75.8 0.0 1.6 1 1 0 1 1 1 1 Periplasmic binding protein domain HTH_3 PF01381.22 ACT00021.1 - 0.024 14.7 0.0 0.05 13.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix MarR PF01047.22 ACT00021.1 - 0.097 12.6 0.1 0.24 11.4 0.1 1.6 1 0 0 1 1 1 0 MarR family HTH_23 PF13384.6 ACT00021.1 - 0.11 12.3 0.0 0.36 10.7 0.0 1.9 1 1 0 1 1 1 0 Homeodomain-like domain CbiJ PF02571.14 ACT00021.1 - 0.15 11.5 0.0 2 7.8 0.0 2.4 3 0 0 3 3 3 0 Precorrin-6x reductase CbiJ/CobK AbrB_C PF18277.1 ACT00021.1 - 0.17 11.5 0.3 3.8 7.2 0.0 3.1 4 0 0 4 4 4 0 AbrB C-terminal domain Fucose_iso_N2 PF07882.12 ACT00022.1 - 2.1e-94 314.2 0.3 3.5e-94 313.5 0.3 1.4 1 0 0 1 1 1 1 L-fucose isomerase, second N-terminal domain Fucose_iso_N1 PF07881.12 ACT00022.1 - 1.4e-80 269.1 0.0 2.2e-80 268.5 0.0 1.3 1 0 0 1 1 1 1 L-fucose isomerase, first N-terminal domain Fucose_iso_C PF02952.17 ACT00022.1 - 4.5e-52 175.6 0.0 9.8e-52 174.5 0.0 1.6 2 0 0 2 2 2 1 L-fucose isomerase, C-terminal domain Aldolase_II PF00596.21 ACT00023.1 - 7.6e-45 153.1 0.0 8.8e-45 152.9 0.0 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain FGGY_C PF02782.16 ACT00024.1 - 6.8e-32 110.8 0.0 2.3e-31 109.1 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ACT00024.1 - 1e-23 84.2 0.0 1.4e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain RbsD_FucU PF05025.13 ACT00025.1 - 4.8e-42 143.6 0.0 5.4e-42 143.4 0.0 1.0 1 0 0 1 1 1 1 RbsD / FucU transport protein family TetR_C_36 PF18598.1 ACT00025.1 - 0.039 13.9 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Glyco_hydro_26 PF02156.15 ACT00026.1 - 4e-12 46.2 1.0 6.5e-12 45.5 1.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 26 Big_7 PF17957.1 ACT00026.1 - 4.2e-05 24.2 0.1 0.00012 22.8 0.1 1.9 1 0 0 1 1 1 1 Bacterial Ig domain TPR_16 PF13432.6 ACT00026.1 - 0.0044 17.6 1.6 0.01 16.5 1.6 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ACT00026.1 - 0.0072 16.4 5.0 0.067 13.3 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Thioredoxin_4 PF13462.6 ACT00026.1 - 0.065 13.4 0.5 0.86 9.7 0.5 2.2 2 0 0 2 2 2 0 Thioredoxin TPR_1 PF00515.28 ACT00026.1 - 0.58 10.1 6.1 1.3 9.0 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat PQQ PF01011.21 ACT00027.1 - 0.043 13.7 0.0 27 4.9 0.0 3.3 4 0 0 4 4 4 0 PQQ enzyme repeat Mor PF08765.11 ACT00028.1 - 1.3e-06 28.3 0.1 2.4e-05 24.3 0.1 2.0 1 1 0 1 1 1 1 Mor transcription activator family FCD PF07729.12 ACT00029.1 - 3.9e-20 72.5 0.0 7.2e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 ACT00029.1 - 8.5e-17 60.6 0.2 2e-16 59.4 0.1 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_41 PF14502.6 ACT00029.1 - 0.00082 19.0 0.2 0.0045 16.6 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain FadR_C PF07840.12 ACT00029.1 - 0.0089 15.9 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 FadR C-terminal domain Post_transc_reg PF13797.6 ACT00029.1 - 0.011 15.6 0.1 0.037 13.9 0.1 1.9 1 0 0 1 1 1 0 Post-transcriptional regulator AvrM_N PF18247.1 ACT00029.1 - 0.044 13.7 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 Flax-rust effector AvrM N-terminal domain CENP-B_N PF04218.13 ACT00029.1 - 0.07 12.8 0.0 0.18 11.4 0.0 1.8 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Cas_Cas1 PF01867.16 ACT00029.1 - 0.11 11.7 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 CRISPR associated protein Cas1 SBP_bac_1 PF01547.25 ACT00030.1 - 4.7e-37 128.6 9.1 7.1e-37 128.0 9.1 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT00030.1 - 2.1e-32 113.0 7.9 2.1e-32 113.0 7.9 1.7 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT00030.1 - 0.00022 20.7 0.1 0.37 10.1 0.0 2.6 2 1 0 2 2 2 2 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT00031.1 - 1.8e-24 86.5 16.6 1.8e-24 86.5 16.6 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00032.1 - 1.5e-19 70.5 15.2 1.5e-19 70.5 15.2 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Cys_Met_Meta_PP PF01053.20 ACT00033.1 - 1.8e-106 355.9 0.0 2.2e-106 355.6 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ACT00033.1 - 1.1e-06 27.9 0.0 1.4e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ACT00033.1 - 1.8e-05 24.2 0.0 0.00012 21.5 0.0 2.0 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 ACT00033.1 - 2.1e-05 23.9 0.0 2.7e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Met_gamma_lyase PF06838.11 ACT00033.1 - 0.00088 17.9 0.0 0.024 13.2 0.0 2.0 1 1 0 1 1 1 1 Methionine gamma-lyase DegT_DnrJ_EryC1 PF01041.17 ACT00033.1 - 0.0012 18.3 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family 4HBT_2 PF13279.6 ACT00034.1 - 8.3e-19 68.3 0.1 9.5e-19 68.1 0.1 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 ACT00034.1 - 6.7e-17 61.6 0.0 9.4e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 ACT00034.1 - 4.1e-16 59.0 4.1 1.8e-10 40.5 0.5 2.5 1 1 1 2 2 2 2 Acyl-ACP thioesterase Phage_TTP_1 PF04630.12 ACT00034.1 - 0.01 15.2 0.1 0.013 14.8 0.1 1.3 1 0 0 1 1 1 0 Phage tail tube protein Aminotran_3 PF00202.21 ACT00035.1 - 1.4e-107 359.8 0.1 1.7e-107 359.6 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 ACT00035.1 - 0.085 12.1 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase TrkH PF02386.16 ACT00036.1 - 7.2e-54 183.1 24.5 9.9e-54 182.6 24.5 1.1 1 0 0 1 1 1 1 Cation transport protein DUF3333 PF11812.8 ACT00036.1 - 0.19 11.9 0.2 0.19 11.9 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3333) DUF445 PF04286.12 ACT00037.1 - 2.4e-64 218.4 1.3 2.7e-64 218.3 1.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF445) ABC_tran PF00005.27 ACT00038.1 - 1.5e-25 90.3 0.0 1.9e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00038.1 - 1.5e-06 28.3 3.4 0.004 17.0 0.4 2.4 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT00038.1 - 0.00043 20.0 0.0 0.00091 18.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_24 PF13479.6 ACT00038.1 - 0.0033 17.2 0.0 0.0049 16.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ACT00038.1 - 0.007 16.3 1.3 0.25 11.3 0.1 2.3 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.6 ACT00038.1 - 0.019 15.2 0.1 0.054 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ACT00038.1 - 0.038 13.9 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase Rad17 PF03215.15 ACT00038.1 - 0.082 12.8 0.0 0.2 11.5 0.0 1.5 2 0 0 2 2 2 0 Rad17 P-loop domain SbcCD_C PF13558.6 ACT00038.1 - 0.091 13.0 0.0 4.2 7.7 0.0 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 ACT00038.1 - 0.18 12.1 0.3 0.65 10.3 0.3 1.8 1 1 0 1 1 1 0 AAA domain UPF0014 PF03649.13 ACT00039.1 - 8.7e-74 247.9 22.7 9.8e-74 247.7 22.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) Col_cuticle_N PF01484.17 ACT00039.1 - 1.6 8.8 0.0 1.6 8.8 0.0 3.4 4 0 0 4 4 4 0 Nematode cuticle collagen N-terminal domain HPP PF04982.13 ACT00039.1 - 7.9 6.7 12.6 2.1 8.6 6.1 2.8 1 1 1 2 2 2 0 HPP family HxlR PF01638.17 ACT00040.1 - 3.8e-29 100.4 0.1 4.4e-29 100.2 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_5 PF01022.20 ACT00040.1 - 0.013 15.3 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family PadR PF03551.14 ACT00040.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family GTP_cyclohydro2 PF00925.20 ACT00041.1 - 1.7e-47 161.0 0.0 4e-47 159.9 0.0 1.5 1 1 1 2 2 2 1 GTP cyclohydrolase II HMGL-like PF00682.19 ACT00043.1 - 6.6e-33 114.4 0.0 5.7e-32 111.3 0.0 1.9 1 1 0 1 1 1 1 HMGL-like Acetyltransf_10 PF13673.7 ACT00044.1 - 2.6e-20 72.6 0.1 3e-20 72.4 0.1 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT00044.1 - 7.4e-11 42.3 0.1 8.9e-11 42.1 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT00044.1 - 1.3e-08 35.1 0.3 1.8e-08 34.7 0.3 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT00044.1 - 6.3e-06 26.1 0.0 1.1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 ACT00044.1 - 1.5e-05 24.7 0.0 2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_9 PF13527.7 ACT00044.1 - 0.00012 22.1 0.2 0.0034 17.5 0.2 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.6 ACT00044.1 - 0.00045 20.9 0.3 0.0015 19.2 0.3 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3762 PF12591.8 ACT00044.1 - 0.18 12.1 0.0 0.34 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3762) VWA PF00092.28 ACT00046.1 - 6.5e-07 29.8 0.1 1.3e-06 28.8 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain bMG3 PF11974.8 ACT00046.1 - 1.2e-06 28.5 0.1 2.4e-06 27.5 0.1 1.6 1 0 0 1 1 1 1 Bacterial alpha-2-macroglobulin MG3 domain CarboxypepD_reg PF13620.6 ACT00046.1 - 0.0001 22.5 0.2 0.00034 20.8 0.2 1.9 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain VWA_2 PF13519.6 ACT00046.1 - 0.00043 20.9 0.1 0.00097 19.8 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Tfb4 PF03850.14 ACT00046.1 - 0.0058 16.1 0.0 0.0093 15.5 0.0 1.3 1 0 0 1 1 1 1 Transcription factor Tfb4 HAD_2 PF13419.6 ACT00047.1 - 1.9e-17 63.9 0.0 2.3e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT00047.1 - 1.5e-12 48.3 0.0 3.4e-12 47.1 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT00047.1 - 2.5e-10 41.1 0.0 3.1e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT00047.1 - 2.6e-05 24.2 0.1 4.5e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 ACT00047.1 - 0.00049 20.2 0.0 1.2 9.3 0.0 2.7 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase Sec39 PF08314.11 ACT00047.1 - 0.00083 17.9 0.1 0.001 17.7 0.1 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 NleF_casp_inhib PF16809.5 ACT00047.1 - 0.0021 18.0 0.1 0.0035 17.3 0.1 1.3 1 0 0 1 1 1 1 NleF caspase inhibitor NIF PF03031.18 ACT00047.1 - 0.007 16.1 0.1 0.021 14.6 0.1 1.8 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase_3 PF08282.12 ACT00047.1 - 0.012 15.4 0.8 0.63 9.7 0.1 2.7 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Ribosomal_L12_N PF16320.5 ACT00047.1 - 0.02 14.6 0.0 0.048 13.4 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain Acid_PPase PF12689.7 ACT00047.1 - 0.057 13.3 0.1 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 Acid Phosphatase GAF PF01590.26 ACT00047.1 - 0.059 14.0 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 GAF domain CT_C_D PF02682.16 ACT00048.1 - 6.1e-63 212.2 0.0 7.3e-63 212.0 0.0 1.0 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D CT_A_B PF02626.15 ACT00049.1 - 3.1e-96 322.1 0.7 4.9e-96 321.4 0.7 1.3 1 1 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B LamB_YcsF PF03746.16 ACT00050.1 - 3.3e-93 311.8 0.4 3.8e-93 311.6 0.4 1.0 1 0 0 1 1 1 1 LamB/YcsF family GGACT PF06094.12 ACT00051.1 - 3.9e-18 66.2 0.0 4.5e-18 66.0 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like MCPsignal PF00015.21 ACT00053.1 - 6.3e-48 162.8 41.9 2.9e-46 157.4 22.3 4.1 2 1 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 ACT00053.1 - 5.6e-16 58.6 1.4 4.5e-14 52.6 0.1 4.4 4 0 0 4 4 4 1 HAMP domain 4HB_MCP_1 PF12729.7 ACT00053.1 - 6.9e-15 55.1 31.6 5e-14 52.2 10.1 4.5 4 1 0 4 4 4 2 Four helix bundle sensory module for signal transduction CHASE3 PF05227.13 ACT00053.1 - 3e-11 43.4 3.8 3e-11 43.4 3.8 4.5 3 2 1 4 4 4 1 CHASE3 domain Laminin_II PF06009.12 ACT00053.1 - 0.00084 19.4 4.8 0.00084 19.4 4.8 5.4 3 3 2 5 5 5 3 Laminin Domain II NTPase_1 PF03266.15 ACT00053.1 - 0.13 12.2 2.2 0.34 10.8 0.1 2.7 3 0 0 3 3 3 0 NTPase SesA PF17107.5 ACT00053.1 - 0.22 11.7 16.9 1 9.6 0.5 4.3 3 2 1 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF948 PF06103.11 ACT00053.1 - 0.28 11.5 39.7 0.39 11.0 0.9 6.2 4 3 3 7 7 7 0 Bacterial protein of unknown function (DUF948) AAA_24 PF13479.6 ACT00053.1 - 0.47 10.1 9.1 3 7.5 1.0 3.3 3 1 0 4 4 4 0 AAA domain DUF2229 PF09989.9 ACT00053.1 - 0.49 10.0 3.5 0.43 10.2 0.4 2.5 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) Sec34 PF04136.15 ACT00053.1 - 3.2 7.6 21.9 2 8.3 0.4 5.1 3 3 2 5 5 5 0 Sec34-like family ThiD2 PF17792.1 ACT00053.1 - 3.2 8.2 11.0 0.35 11.4 2.0 3.0 3 0 0 3 3 3 0 ThiD2 family DUF1664 PF07889.12 ACT00053.1 - 3.5 7.7 30.2 0.93 9.5 1.0 5.3 3 3 3 6 6 6 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.13 ACT00053.1 - 4.7 8.0 13.4 3 8.6 1.3 4.6 4 2 1 5 5 5 0 Occludin homology domain MFS_1 PF07690.16 ACT00054.1 - 4.1e-40 137.8 71.2 9e-32 110.4 46.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2631 PF10939.8 ACT00054.1 - 4.1 7.3 10.7 1.6 8.6 0.1 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF2631) MarR PF01047.22 ACT00055.1 - 1.7e-10 40.6 0.1 7.1e-10 38.7 0.1 2.0 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.6 ACT00055.1 - 5.8e-09 35.4 0.0 2.3e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ACT00055.1 - 5.4e-08 32.6 0.2 2.4e-07 30.5 0.0 2.2 2 1 1 3 3 2 1 MarR family HTH_Crp_2 PF13545.6 ACT00055.1 - 1.9e-05 24.5 0.3 0.00011 22.1 0.0 2.2 2 1 0 2 2 2 1 Crp-like helix-turn-helix domain HxlR PF01638.17 ACT00055.1 - 0.0011 18.7 0.2 0.0034 17.2 0.2 1.7 1 1 0 1 1 1 1 HxlR-like helix-turn-helix HTH_3 PF01381.22 ACT00055.1 - 0.0016 18.5 0.0 0.0045 17.0 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix Fe_dep_repress PF01325.19 ACT00055.1 - 0.0019 18.4 0.0 0.0048 17.1 0.0 1.7 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_11 PF08279.12 ACT00055.1 - 0.0024 17.8 0.1 0.0057 16.6 0.1 1.7 1 0 0 1 1 1 1 HTH domain GntR PF00392.21 ACT00055.1 - 0.0028 17.3 0.1 0.0086 15.7 0.0 1.8 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_27 PF13463.6 ACT00055.1 - 0.0042 17.6 0.0 0.0084 16.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain Penicillinase_R PF03965.16 ACT00055.1 - 0.0045 17.3 0.4 0.0081 16.5 0.4 1.5 2 0 0 2 2 2 1 Penicillinase repressor HTH_1 PF00126.27 ACT00055.1 - 0.0061 16.5 0.7 0.17 11.9 0.0 3.1 4 0 0 4 4 4 1 Bacterial regulatory helix-turn-helix protein, lysR family B-block_TFIIIC PF04182.12 ACT00055.1 - 0.0083 16.3 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC TrmB PF01978.19 ACT00055.1 - 0.012 15.5 0.3 0.22 11.4 0.1 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Ribosomal_S25 PF03297.15 ACT00055.1 - 0.028 14.6 0.0 0.047 13.9 0.0 1.4 1 0 0 1 1 1 0 S25 ribosomal protein Rrf2 PF02082.20 ACT00055.1 - 0.056 13.8 0.0 0.33 11.3 0.0 2.1 2 0 0 2 2 2 0 Transcriptional regulator HTH_34 PF13601.6 ACT00055.1 - 0.066 13.4 0.1 0.23 11.7 0.1 1.9 2 0 0 2 2 2 0 Winged helix DNA-binding domain HTH_IclR PF09339.10 ACT00055.1 - 0.098 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain HisKA_3 PF07730.13 ACT00057.1 - 5.8e-14 52.4 3.5 8.1e-13 48.7 1.1 2.5 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACT00057.1 - 1.8e-05 25.2 0.2 6.8e-05 23.3 0.2 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT00057.1 - 0.00034 20.6 0.1 0.00062 19.7 0.1 1.6 1 1 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACT00057.1 - 0.017 15.0 0.2 0.05 13.4 0.1 1.8 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2120 PF09893.9 ACT00057.1 - 0.085 13.0 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) EMC3_TMCO1 PF01956.16 ACT00057.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Response_reg PF00072.24 ACT00058.1 - 1.1e-27 96.4 0.0 3.3e-27 94.9 0.0 1.8 2 0 0 2 2 2 1 Response regulator receiver domain GerE PF00196.19 ACT00058.1 - 8.1e-21 73.3 0.1 2.2e-20 72.0 0.1 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACT00058.1 - 3.2e-07 29.9 0.0 6.6e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT00058.1 - 5.1e-06 25.9 0.0 9.6e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_10 PF04967.12 ACT00058.1 - 0.0015 18.3 0.1 0.015 15.1 0.1 2.5 2 0 0 2 2 2 1 HTH DNA binding domain HTH_23 PF13384.6 ACT00058.1 - 0.0062 16.3 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_40 PF14493.6 ACT00058.1 - 0.0065 16.9 0.1 0.11 13.0 0.0 2.3 2 1 0 2 2 2 1 Helix-turn-helix domain Sigma70_ECF PF07638.11 ACT00058.1 - 0.0088 15.9 0.0 0.024 14.6 0.0 1.7 2 0 0 2 2 2 1 ECF sigma factor DUF3071 PF11268.8 ACT00058.1 - 0.04 14.0 0.0 0.05 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Lipoprotein_11 PF03260.13 ACT00058.1 - 0.047 13.1 0.0 0.068 12.5 0.0 1.1 1 0 0 1 1 1 0 Lepidopteran low molecular weight (30 kD) lipoprotein CENP-B_N PF04218.13 ACT00058.1 - 0.053 13.2 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_38 PF13936.6 ACT00058.1 - 0.057 13.2 0.1 0.53 10.1 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain DUF2089 PF09862.9 ACT00058.1 - 0.088 12.8 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) RP-C PF03428.13 ACT00058.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Replication protein C N-terminal domain HTH_11 PF08279.12 ACT00058.1 - 0.14 12.1 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 HTH domain tRNA-synt_2d PF01409.20 ACT00059.1 - 2e-105 351.7 0.0 2.5e-105 351.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) Phe_tRNA-synt_N PF02912.18 ACT00059.1 - 8.2e-23 80.1 2.7 8.4e-23 80.1 0.2 2.1 2 0 0 2 2 2 1 Aminoacyl tRNA synthetase class II, N-terminal domain B3_4 PF03483.17 ACT00060.1 - 5.5e-70 234.5 0.0 9.8e-70 233.7 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain tRNA_synthFbeta PF17759.1 ACT00060.1 - 6.2e-65 218.6 0.0 1.1e-64 217.8 0.0 1.4 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain FDX-ACB PF03147.14 ACT00060.1 - 5.3e-31 106.9 0.0 1.8e-30 105.2 0.0 2.0 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain tRNA_bind PF01588.20 ACT00060.1 - 5e-27 93.9 0.4 1.1e-26 92.8 0.4 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain B5 PF03484.15 ACT00060.1 - 8e-18 64.5 0.1 4.5e-17 62.1 0.0 2.4 2 1 0 2 2 2 1 tRNA synthetase B5 domain tRNA-synt_2d PF01409.20 ACT00060.1 - 0.17 11.4 0.0 0.37 10.2 0.0 1.5 1 1 0 1 1 1 0 tRNA synthetases class II core domain (F) TrmB PF01978.19 ACT00061.1 - 6.5 6.7 20.4 3.7 7.5 0.2 8.3 10 0 0 10 10 10 0 Sugar-specific transcriptional regulator TrmB adh_short PF00106.25 ACT00062.1 - 5.6e-56 189.1 0.0 6.6e-56 188.9 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT00062.1 - 1.8e-46 158.6 0.0 2.2e-46 158.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT00062.1 - 2.4e-15 56.9 0.1 3.1e-15 56.5 0.1 1.0 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ACT00062.1 - 0.00012 21.6 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) 3HCDH_N PF02737.18 ACT00062.1 - 0.025 14.5 0.1 0.037 13.9 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain CdAMP_rec PF06153.11 ACT00062.1 - 0.18 12.0 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Cyclic-di-AMP receptor Cupredoxin_1 PF13473.6 ACT00063.1 - 1.4e-06 28.3 0.1 2e-06 27.9 0.1 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain Pilus_CpaD PF09476.10 ACT00063.1 - 0.043 13.5 0.3 1.6 8.4 0.1 2.0 1 1 1 2 2 2 0 Pilus biogenesis CpaD protein (pilus_cpaD) Phage_holin_4_2 PF04020.13 ACT00064.1 - 2.8e-13 50.5 20.2 3.3e-13 50.2 20.2 1.0 1 0 0 1 1 1 1 Mycobacterial 4 TMS phage holin, superfamily IV DUF3180 PF11377.8 ACT00064.1 - 0.0056 16.8 10.9 0.0083 16.3 10.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3180) DUF2512 PF10710.9 ACT00064.1 - 1.2 8.8 13.5 2 8.1 13.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2512) MutS_V PF00488.21 ACT00065.1 - 2.3e-37 128.9 1.0 3.8e-37 128.2 0.2 1.7 2 0 0 2 2 2 1 MutS domain V Smr PF01713.21 ACT00065.1 - 2.3e-18 66.3 0.5 1.1e-17 64.1 0.5 2.3 1 0 0 1 1 1 1 Smr domain Sulfatase_C PF14707.6 ACT00065.1 - 0.022 15.5 8.6 0.029 15.1 0.0 3.6 3 1 1 4 4 4 0 C-terminal region of aryl-sulfatase Exonuc_VII_L PF02601.15 ACT00065.1 - 0.34 10.4 11.1 0.32 10.5 4.4 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 ACT00065.1 - 0.63 7.9 2.5 1.4 6.7 2.5 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vir_act_alpha_C PF10400.9 ACT00065.1 - 5.5 7.8 13.3 1.7 9.4 4.8 4.0 4 0 0 4 4 4 0 Virulence activator alpha C-term DUF350 PF03994.14 ACT00066.1 - 5.1e-26 90.6 7.7 7.2e-13 48.5 2.9 2.2 2 0 0 2 2 2 2 Domain of Unknown Function (DUF350) CrgA PF06781.12 ACT00066.1 - 0.18 11.9 5.2 3.2 7.9 0.6 2.1 2 0 0 2 2 2 0 Cell division protein CrgA DUF2304 PF10066.9 ACT00066.1 - 0.39 11.0 9.5 1.9 8.7 5.5 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Cytochrom_C_asm PF01578.20 ACT00066.1 - 6.7 6.4 12.0 1.9 8.2 1.8 2.3 2 1 1 3 3 3 0 Cytochrome C assembly protein DZR PF12773.7 ACT00067.1 - 0.002 18.1 5.1 0.11 12.6 0.3 2.7 2 1 0 2 2 2 2 Double zinc ribbon zinc-ribbons_6 PF07191.12 ACT00067.1 - 0.012 15.6 8.7 0.071 13.1 0.9 3.1 2 1 1 3 3 3 0 zinc-ribbons zf-C2HC5 PF06221.13 ACT00067.1 - 0.017 15.1 8.1 13 5.8 0.3 4.1 3 1 1 4 4 4 0 Putative zinc finger motif, C2HC5-type zf-ribbon_3 PF13248.6 ACT00067.1 - 0.02 14.3 12.5 2.3 7.7 0.1 4.2 4 0 0 4 4 4 0 zinc-ribbon domain RNHCP PF12647.7 ACT00067.1 - 0.028 14.4 1.3 0.3 11.1 0.2 2.7 3 0 0 3 3 3 0 RNHCP domain zf-TFIIB PF13453.6 ACT00067.1 - 0.031 13.6 5.2 6.6 6.2 0.1 3.9 4 0 0 4 4 4 0 Transcription factor zinc-finger zinc_ribbon_9 PF14369.6 ACT00067.1 - 0.079 13.2 11.0 17 5.8 0.1 4.4 3 1 1 4 4 4 0 zinc-ribbon Zn-ribbon_8 PF09723.10 ACT00067.1 - 0.089 12.9 13.3 5.6 7.2 0.2 4.2 3 1 1 4 4 4 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 ACT00067.1 - 0.11 12.4 8.4 0.39 10.7 0.2 3.8 3 1 1 4 4 4 0 Transposase zinc-ribbon domain zf-RING_4 PF14570.6 ACT00067.1 - 0.12 12.1 9.4 1 9.2 1.6 3.2 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 ACT00067.1 - 0.13 12.2 6.9 2.3 8.2 0.7 3.4 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) HypA PF01155.19 ACT00067.1 - 0.19 11.8 6.0 1.8 8.6 0.4 2.7 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_9 PF16293.5 ACT00067.1 - 0.3 11.0 5.1 25 4.8 0.0 4.1 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) CDC45 PF02724.14 ACT00067.1 - 0.42 8.9 4.4 0.44 8.8 4.4 1.0 1 0 0 1 1 1 0 CDC45-like protein zinc_ribbon_2 PF13240.6 ACT00067.1 - 0.68 9.7 10.6 10 6.0 0.6 4.1 4 0 0 4 4 4 0 zinc-ribbon domain zf-C4_Topoisom PF01396.19 ACT00067.1 - 1.4 8.8 9.8 32 4.4 0.0 3.9 4 0 0 4 4 4 0 Topoisomerase DNA binding C4 zinc finger YdjO PF14169.6 ACT00067.1 - 2.3 8.0 11.3 1.2 8.9 0.2 3.6 3 1 1 4 4 4 0 Cold-inducible protein YdjO Auto_anti-p27 PF06677.12 ACT00067.1 - 2.4 8.4 8.1 18 5.6 1.5 3.4 3 1 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Zn_ribbon_SprT PF17283.2 ACT00067.1 - 3.6 7.6 7.1 15 5.6 0.1 3.4 4 0 0 4 4 4 0 SprT-like zinc ribbon domain zf-LITAF-like PF10601.9 ACT00067.1 - 4.3 7.7 12.1 30 5.0 0.3 3.9 3 1 0 3 3 3 0 LITAF-like zinc ribbon domain TerY_C PF15616.6 ACT00067.1 - 5 7.2 11.8 5.6 7.1 0.2 3.9 2 1 2 4 4 4 0 TerY-C metal binding domain Zn_Tnp_IS1 PF03811.13 ACT00067.1 - 9.6 6.0 11.8 11 5.9 0.1 3.8 4 0 0 4 4 4 0 InsA N-terminal domain DiS_P_DiS PF06750.13 ACT00067.1 - 9.6 6.4 7.4 6.4 7.0 0.2 3.1 3 1 1 4 4 3 0 Bacterial Peptidase A24 N-terminal domain MFS_1 PF07690.16 ACT00068.1 - 9.7e-14 51.1 33.2 9.7e-14 51.1 33.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ACT00068.1 - 0.29 9.9 20.9 0.013 14.4 13.7 2.0 1 1 1 2 2 2 0 MFS_1 like family DUF4267 PF14087.6 ACT00068.1 - 6.4 6.9 11.8 3.1 7.9 0.3 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4267) PALP PF00291.25 ACT00069.1 - 1.6e-67 228.0 0.3 1.8e-67 227.8 0.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 ACT00069.1 - 0.00045 20.2 0.5 0.028 14.4 0.2 2.6 2 1 0 2 2 2 2 Zinc-binding dehydrogenase CotH PF08757.11 ACT00070.1 - 3.7e-64 217.3 0.1 4.6e-64 217.0 0.1 1.0 1 0 0 1 1 1 1 CotH kinase protein DUF2642 PF10842.8 ACT00071.1 - 2.7e-05 23.9 0.2 0.009 15.8 0.0 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF2642) DUF150_C PF17384.2 ACT00071.1 - 0.01 16.0 0.5 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 RimP C-terminal SH3 domain CarD_CdnL_TRCF PF02559.16 ACT00071.1 - 0.056 14.2 0.1 2.7 8.8 0.2 2.3 1 1 1 2 2 2 0 CarD-like/TRCF domain DUF2642 PF10842.8 ACT00072.1 - 9.6e-05 22.2 0.3 0.18 11.7 0.0 3.2 3 0 0 3 3 3 3 Protein of unknown function (DUF2642) Spore_permease PF03845.13 ACT00073.1 - 1.5e-21 76.6 30.3 1.5e-21 76.6 30.3 1.8 1 1 0 2 2 2 1 Spore germination protein GerA PF03323.13 ACT00074.1 - 4.2e-143 477.2 0.3 5.4e-143 476.8 0.3 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein CENP-R PF06729.12 ACT00074.1 - 0.16 11.9 0.1 0.28 11.1 0.1 1.3 1 0 0 1 1 1 0 Kinetochore component, CENP-R Spore_GerAC PF05504.11 ACT00075.1 - 6.2e-23 81.8 0.5 1.1e-22 81.0 0.5 1.4 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal Coat_F PF07875.12 ACT00076.1 - 0.06 13.6 3.2 0.084 13.1 3.2 1.3 1 0 0 1 1 1 0 Coat F domain Coat_F PF07875.12 ACT00077.1 - 1.6e-20 73.1 0.3 1.6e-20 73.1 0.3 2.5 2 1 1 3 3 3 2 Coat F domain DUF515 PF04415.12 ACT00077.1 - 0.01 14.3 0.7 0.01 14.3 0.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) MRP-S27 PF10037.9 ACT00077.1 - 0.04 12.8 4.4 0.041 12.7 4.4 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 DUF4407 PF14362.6 ACT00077.1 - 0.07 12.5 2.4 0.076 12.4 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Uteroglobin PF01099.17 ACT00077.1 - 0.073 13.4 0.9 0.11 12.9 0.9 1.3 1 0 0 1 1 1 0 Uteroglobin family Exonuc_VII_L PF02601.15 ACT00077.1 - 0.59 9.7 5.3 0.68 9.4 5.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit AsnC_trans_reg PF01037.21 ACT00078.1 - 1.8e-15 56.7 0.0 3.7e-15 55.7 0.0 1.5 2 0 0 2 2 2 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 ACT00078.1 - 0.0026 17.3 0.1 0.032 13.8 0.1 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Phage_rep_org_N PF09681.10 ACT00078.1 - 0.0062 16.5 0.5 0.015 15.2 0.1 1.7 2 0 0 2 2 2 1 N-terminal phage replisome organiser (Phage_rep_org_N) Aminotran_1_2 PF00155.21 ACT00079.1 - 2.1e-72 244.3 0.0 2.4e-72 244.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ACT00079.1 - 1.2e-07 31.0 0.0 2.7e-07 29.9 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ACT00079.1 - 5.3e-07 28.5 0.0 9.1e-07 27.7 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ACT00079.1 - 1.9e-06 27.4 0.0 3.6e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 ACT00079.1 - 0.0049 16.2 0.0 0.008 15.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase OKR_DC_1 PF01276.20 ACT00079.1 - 0.12 11.0 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Cob_adeno_trans PF01923.18 ACT00080.1 - 9.8e-59 198.2 0.0 1.1e-58 198.0 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase PseudoU_synth_2 PF00849.22 ACT00081.1 - 7.5e-33 113.9 0.0 1.1e-32 113.3 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase ArsC PF03960.15 ACT00082.1 - 1.3e-18 66.8 0.0 1.5e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 ArsC family Glutaredoxin PF00462.24 ACT00082.1 - 0.034 14.4 0.0 0.058 13.6 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin AhpC-TSA PF00578.21 ACT00082.1 - 0.069 13.1 0.0 0.085 12.8 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family DUF836 PF05768.14 ACT00082.1 - 0.086 13.3 0.2 0.14 12.6 0.0 1.6 2 0 0 2 2 2 0 Glutaredoxin-like domain (DUF836) Aminotran_1_2 PF00155.21 ACT00083.1 - 6.8e-59 199.9 0.0 7.7e-59 199.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ACT00083.1 - 0.0012 18.3 0.0 0.0019 17.6 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family OKR_DC_1 PF01276.20 ACT00083.1 - 0.087 11.5 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Cys_Met_Meta_PP PF01053.20 ACT00083.1 - 0.21 10.1 0.0 0.31 9.5 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme 5_3_exonuc_N PF02739.16 ACT00084.1 - 5.1e-54 182.5 0.0 9.8e-54 181.6 0.0 1.4 2 0 0 2 2 2 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 ACT00084.1 - 1.1e-28 99.7 0.1 2.4e-28 98.6 0.0 1.6 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.7 ACT00084.1 - 0.00026 21.0 0.1 0.013 15.5 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 ACT00084.1 - 0.0036 17.9 0.1 0.0083 16.7 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain SLH PF00395.20 ACT00085.1 - 4.1e-38 129.1 1.3 4.3e-13 49.0 0.1 4.6 4 0 0 4 4 4 3 S-layer homology domain DUF5011 PF16403.5 ACT00085.1 - 2.8e-12 46.6 5.0 2.8e-12 46.6 5.0 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF5011) TGFb_propeptide PF00688.18 ACT00085.1 - 0.011 15.4 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 TGF-beta propeptide FG-GAP PF01839.23 ACT00085.1 - 0.033 14.3 7.8 2.5 8.3 0.3 5.0 4 0 0 4 4 4 0 FG-GAP repeat YjzC PF14168.6 ACT00085.1 - 0.82 10.1 7.1 1.7e+02 2.6 0.0 6.2 6 0 0 6 6 6 0 YjzC-like protein Disaggr_repeat PF06848.11 ACT00085.1 - 5.8 6.5 8.7 7.7 6.1 0.0 5.2 6 1 1 7 7 7 0 Disaggregatase related repeat DUF4384 PF14326.6 ACT00085.1 - 6.5 6.9 9.1 79 3.5 0.2 5.8 6 0 0 6 6 6 0 Domain of unknown function (DUF4384) Acetyltransf_1 PF00583.25 ACT00086.1 - 2.2e-10 40.8 0.1 2.9e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT00086.1 - 7.5e-10 38.8 0.0 9.1e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT00086.1 - 3.5e-08 33.7 0.0 4.5e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACT00086.1 - 1.8e-06 28.7 0.0 2.4e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT00086.1 - 1.3e-05 25.1 0.1 4.7e-05 23.3 0.1 1.8 1 1 1 2 2 2 1 FR47-like protein GNAT_acetyltran PF12746.7 ACT00086.1 - 0.00054 19.6 0.0 0.00073 19.2 0.0 1.1 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_CG PF14542.6 ACT00086.1 - 0.14 12.3 0.0 0.22 11.7 0.0 1.5 1 1 0 1 1 1 0 GCN5-related N-acetyl-transferase Collar PF07484.12 ACT00087.1 - 6.6e-27 93.3 0.3 1.4e-26 92.3 0.3 1.6 1 0 0 1 1 1 1 Phage Tail Collar Domain Collar PF07484.12 ACT00088.1 - 6.9e-27 93.2 0.7 1.4e-26 92.3 0.7 1.5 1 0 0 1 1 1 1 Phage Tail Collar Domain Collar PF07484.12 ACT00089.1 - 2.5e-26 91.5 0.4 4.4e-26 90.7 0.4 1.4 1 0 0 1 1 1 1 Phage Tail Collar Domain DUF3055 PF11256.8 ACT00091.1 - 4.1e-33 113.5 0.3 4.9e-33 113.2 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3055) HRDC PF00570.23 ACT00092.1 - 7.8e-16 57.8 0.1 1.8e-15 56.6 0.1 1.7 1 0 0 1 1 1 1 HRDC domain Anticodon_1 PF08264.13 ACT00092.1 - 0.038 13.9 0.2 0.083 12.9 0.2 1.6 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA HHH PF00633.23 ACT00092.1 - 0.039 13.8 0.0 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif HTH_40 PF14493.6 ACT00092.1 - 0.065 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Zn_dep_PLPC PF00882.18 ACT00093.1 - 3.6e-05 23.8 0.0 5.3e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Zinc dependent phospholipase C CheX PF13690.6 ACT00094.1 - 2.9e-14 53.0 0.4 4.1e-14 52.5 0.4 1.3 1 0 0 1 1 1 1 Chemotaxis phosphatase CheX CheC PF04509.12 ACT00094.1 - 1.5e-10 40.8 0.5 5.2e-10 39.1 0.5 1.9 1 0 0 1 1 1 1 CheC-like family adh_short PF00106.25 ACT00095.1 - 1.7e-58 197.3 1.0 2.1e-58 197.0 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT00095.1 - 6.5e-44 150.2 0.4 7.6e-44 150.0 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT00095.1 - 6.6e-14 52.2 0.3 9.5e-14 51.7 0.3 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 ACT00095.1 - 0.005 17.1 0.1 0.0079 16.4 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ACT00095.1 - 0.019 15.0 0.1 0.031 14.3 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AdoHcyase_NAD PF00670.21 ACT00095.1 - 0.034 14.2 0.5 0.058 13.5 0.5 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Methyltransf_25 PF13649.6 ACT00095.1 - 0.035 14.8 0.0 0.097 13.4 0.0 1.8 1 1 1 2 2 2 0 Methyltransferase domain Epimerase PF01370.21 ACT00095.1 - 0.059 12.8 0.1 0.13 11.7 0.1 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DEAD PF00270.29 ACT00096.1 - 1.3e-44 152.0 0.1 2.2e-44 151.3 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ACT00096.1 - 2.4e-23 82.6 0.0 5.3e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT00096.1 - 4.5e-05 23.5 0.0 8.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ACT00096.1 - 0.00055 19.3 0.0 0.0012 18.2 0.0 1.6 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Methyltransf_23 PF13489.6 ACT00096.1 - 0.004 17.0 0.0 0.0087 15.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain SLH PF00395.20 ACT00097.1 - 2e-35 120.6 3.5 1.8e-15 56.7 0.1 3.7 3 0 0 3 3 3 3 S-layer homology domain OHA PF14418.6 ACT00097.1 - 0.02 14.7 0.0 0.65 9.9 0.0 2.5 2 0 0 2 2 2 0 OST-HTH Associated domain HPS3_N PF14761.6 ACT00097.1 - 0.034 13.7 0.1 0.059 12.9 0.1 1.4 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Flocculin PF00624.18 ACT00097.1 - 0.11 12.8 1.5 0.34 11.2 1.5 1.9 1 0 0 1 1 1 0 Flocculin repeat Lipocalin_4 PF13648.6 ACT00097.1 - 8.5 7.4 10.1 15 6.6 6.0 3.2 2 1 0 2 2 2 0 Lipocalin-like domain ABC_tran PF00005.27 ACT00098.1 - 7.3e-32 110.8 0.0 9.2e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00098.1 - 2.8e-11 43.8 0.8 2.7e-07 30.7 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ACT00098.1 - 0.0021 18.5 0.0 0.0029 18.0 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT00098.1 - 0.0049 16.6 0.1 0.0096 15.6 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ACT00098.1 - 0.016 15.3 0.0 0.028 14.5 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.19 ACT00098.1 - 0.018 14.5 0.2 0.23 10.8 0.2 2.0 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 ACT00098.1 - 0.033 13.5 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 ACT00098.1 - 0.058 13.9 0.0 0.11 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ACT00098.1 - 0.071 13.0 0.0 0.84 9.5 0.0 2.0 2 0 0 2 2 2 0 NTPase MeaB PF03308.16 ACT00098.1 - 0.082 11.9 0.1 0.12 11.3 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 ACT00098.1 - 0.14 12.4 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain EcsB PF05975.12 ACT00099.1 - 7e-98 328.0 29.7 8.1e-98 327.8 29.7 1.0 1 0 0 1 1 1 1 Bacterial ABC transporter protein EcsB Aminotran_1_2 PF00155.21 ACT00100.1 - 1.1e-30 107.0 0.0 1.4e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II HTH_18 PF12833.7 ACT00102.1 - 2.3e-19 69.4 0.3 3.8e-19 68.7 0.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00102.1 - 4e-17 61.9 0.2 4.9e-09 36.1 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT00102.1 - 6.9e-09 35.7 0.1 5.2e-08 32.9 0.0 2.1 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT00102.1 - 8.4e-06 25.4 0.0 1.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding_2 PF14525.6 ACT00102.1 - 0.00078 19.2 0.0 0.003 17.3 0.0 1.9 1 1 1 2 2 2 1 AraC-binding-like domain CENP-C_C PF11699.8 ACT00102.1 - 0.0075 16.5 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_3 PF05899.12 ACT00102.1 - 0.0082 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) HTH_23 PF13384.6 ACT00102.1 - 0.16 11.8 0.5 0.84 9.5 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain PS_Dcarbxylase PF02666.15 ACT00103.1 - 8.7e-62 208.2 0.0 1e-61 208.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase HTH_Tnp_Tc5 PF03221.16 ACT00103.1 - 0.15 12.1 0.2 0.47 10.5 0.1 1.9 2 1 0 2 2 2 0 Tc5 transposase DNA-binding domain Glycos_transf_1 PF00534.20 ACT00104.1 - 1.1e-34 119.4 0.0 1.7e-34 118.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT00104.1 - 4.5e-28 98.3 0.0 1.4e-27 96.8 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ACT00104.1 - 7.4e-12 45.5 0.0 3e-11 43.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACT00104.1 - 3.5e-08 33.6 0.1 3.5e-08 33.6 0.1 2.0 2 1 0 2 2 2 1 Glycosyltransferase Family 4 HC2 PF07382.11 ACT00105.1 - 1.4e-05 25.2 28.4 0.2 11.7 2.9 6.7 2 1 2 6 6 6 5 Histone H1-like nucleoprotein HC2 TrmE_N PF10396.9 ACT00105.1 - 0.0055 17.0 29.7 2.7 8.3 1.4 11.8 4 4 4 9 9 9 2 GTP-binding protein TrmE N-terminus AAA_3 PF07726.11 ACT00105.1 - 1.2 9.0 8.3 63 3.4 0.2 6.2 7 1 1 8 8 8 0 ATPase family associated with various cellular activities (AAA) SICA_C PF12879.7 ACT00105.1 - 3.7 7.6 11.9 48 4.0 0.0 7.4 7 1 2 9 9 9 0 SICA C-terminal inner membrane domain Glycos_transf_2 PF00535.26 ACT00106.1 - 3e-20 72.7 0.0 3.9e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACT00106.1 - 2.2e-11 44.1 0.2 2.8e-11 43.8 0.2 1.2 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ACT00106.1 - 2.2e-07 30.6 0.0 2.7e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 ACT00106.1 - 0.047 14.2 0.0 0.09 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Prenyltrans PF00432.21 ACT00106.1 - 0.052 13.3 0.0 0.093 12.5 0.0 1.3 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat DUF1529 PF07485.11 ACT00106.1 - 0.13 12.1 0.6 1.1 9.1 0.0 2.5 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1259) NTP_transferase PF00483.23 ACT00107.1 - 1.4e-52 178.7 0.0 1.7e-52 178.5 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACT00107.1 - 2.2e-14 54.1 0.0 2.7e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 ACT00107.1 - 0.022 14.5 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase DUF3530 PF12048.8 ACT00107.1 - 0.17 11.3 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Glycos_transf_2 PF00535.26 ACT00108.1 - 9.1e-30 103.7 0.0 1.4e-29 103.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACT00108.1 - 5.8e-14 52.5 0.0 8e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ACT00108.1 - 2.7e-06 27.1 0.0 4.6e-06 26.3 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_5 PF13712.6 ACT00108.1 - 0.00068 19.4 0.0 0.0018 18.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family Glyco_tranf_2_4 PF13704.6 ACT00108.1 - 0.0048 17.4 0.0 0.01 16.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Sec20 PF03908.13 ACT00109.1 - 0.014 15.3 0.1 0.016 15.1 0.1 1.2 1 0 0 1 1 1 0 Sec20 CARMIL_C PF16000.5 ACT00109.1 - 0.026 14.2 0.0 0.026 14.2 0.0 1.1 1 0 0 1 1 1 0 CARMIL C-terminus Vps53_N PF04100.12 ACT00111.1 - 0.0082 15.1 0.5 0.009 15.0 0.5 1.0 1 0 0 1 1 1 1 Vps53-like, N-terminal Baculo_PEP_C PF04513.12 ACT00111.1 - 0.069 13.2 1.4 0.087 12.9 1.4 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus rve_3 PF13683.6 ACT00111.1 - 0.15 11.8 0.1 0.66 9.8 0.0 2.1 2 1 1 3 3 3 0 Integrase core domain Yae1_N PF09811.9 ACT00112.1 - 0.001 18.7 1.2 0.0044 16.7 1.2 2.0 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Kri1 PF05178.12 ACT00112.1 - 0.012 16.2 0.5 0.013 16.0 0.5 1.1 1 0 0 1 1 1 0 KRI1-like family DUF1367 PF07105.11 ACT00112.1 - 0.013 15.2 0.6 0.015 14.9 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1367) DUF4120 PF13496.6 ACT00112.1 - 0.092 13.1 0.0 0.12 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4120) Glyco_trans_1_2 PF13524.6 ACT00113.1 - 8.9e-21 74.1 0.0 1.5e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF3880 PF12996.7 ACT00113.1 - 3.1e-19 68.8 0.3 5.7e-19 68.0 0.3 1.5 1 0 0 1 1 1 1 DUF based on E. rectale Gene description (DUF3880) Yae1_N PF09811.9 ACT00113.1 - 0.00057 19.5 0.4 0.0015 18.2 0.4 1.7 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Glyco_trans_1_2 PF13524.6 ACT00114.1 - 2.2e-25 88.9 0.1 3.9e-25 88.1 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF3880 PF12996.7 ACT00114.1 - 7.5e-20 70.8 0.5 2.8e-19 69.0 0.3 2.0 2 0 0 2 2 2 1 DUF based on E. rectale Gene description (DUF3880) DUF2827 PF10933.8 ACT00114.1 - 0.0049 15.6 0.0 0.0099 14.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2827) ACP_syn_III_C PF08541.10 ACT00115.1 - 4.2e-33 113.4 0.0 2.3e-32 111.0 0.0 2.2 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 ACT00115.1 - 3.5e-28 97.3 0.7 6.2e-28 96.5 0.7 1.4 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 ACT00115.1 - 2.4e-08 33.7 0.3 5.8e-08 32.4 0.1 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain HMG_CoA_synt_N PF01154.17 ACT00115.1 - 0.0098 15.8 0.1 0.014 15.2 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Chal_sti_synt_C PF02797.15 ACT00115.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Chalcone and stilbene synthases, C-terminal domain FAE1_CUT1_RppA PF08392.12 ACT00115.1 - 0.14 11.4 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein Spore_YhcN_YlaJ PF09580.10 ACT00116.1 - 8.7e-23 81.2 12.0 8e-14 52.0 0.0 2.6 1 1 2 3 3 3 2 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Collagen PF01391.18 ACT00116.1 - 3.2 7.6 8.9 0.69 9.7 5.6 1.6 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) GerE PF00196.19 ACT00117.1 - 4.1e-23 80.7 0.5 5.1e-23 80.4 0.5 1.1 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACT00117.1 - 1.2e-09 37.7 0.2 4.4e-09 35.9 0.1 1.8 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT00117.1 - 4.5e-07 29.3 0.4 1.1e-06 28.0 0.2 1.6 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_10 PF04967.12 ACT00117.1 - 0.00035 20.3 0.2 0.0012 18.6 0.0 1.8 2 0 0 2 2 2 1 HTH DNA binding domain HTH_Tnp_ISL3 PF13542.6 ACT00117.1 - 0.00055 19.3 0.0 0.00087 18.7 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_11 PF08279.12 ACT00117.1 - 0.00089 19.2 0.2 0.0014 18.5 0.2 1.4 1 1 0 1 1 1 1 HTH domain HTH_23 PF13384.6 ACT00117.1 - 0.00097 18.9 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain KORA PF16509.5 ACT00117.1 - 0.0013 19.0 0.3 0.0015 18.7 0.3 1.1 1 0 0 1 1 1 1 TrfB plasmid transcriptional repressor HTH_40 PF14493.6 ACT00117.1 - 0.0018 18.7 0.1 0.002 18.6 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain Mga PF05043.13 ACT00117.1 - 0.0045 17.6 0.2 0.0063 17.1 0.2 1.4 1 1 0 1 1 1 1 Mga helix-turn-helix domain Trans_reg_C PF00486.28 ACT00117.1 - 0.0049 16.9 0.7 0.16 12.0 0.7 2.0 1 1 0 1 1 1 1 Transcriptional regulatory protein, C terminal Phage_terminase PF10668.9 ACT00117.1 - 0.0065 16.5 0.0 0.0083 16.1 0.0 1.3 1 0 0 1 1 1 1 Phage terminase small subunit HTH_24 PF13412.6 ACT00117.1 - 0.0076 15.8 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding SpoIIID PF12116.8 ACT00117.1 - 0.011 15.8 0.3 0.012 15.7 0.3 1.1 1 0 0 1 1 1 0 Stage III sporulation protein D HTH_DeoR PF08220.12 ACT00117.1 - 0.019 14.7 0.8 0.023 14.4 0.2 1.6 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain DUF2089 PF09862.9 ACT00117.1 - 0.019 15.0 0.1 0.019 15.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) HTH_38 PF13936.6 ACT00117.1 - 0.02 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain UPF0122 PF04297.14 ACT00117.1 - 0.02 15.1 0.1 0.025 14.8 0.1 1.2 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like HTH_30 PF13556.6 ACT00117.1 - 0.039 13.8 0.0 0.049 13.4 0.0 1.2 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain TrmB PF01978.19 ACT00117.1 - 0.061 13.2 0.0 0.085 12.7 0.0 1.4 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.20 ACT00117.1 - 0.077 12.9 0.0 0.15 11.9 0.0 1.5 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Dimerisation2 PF16864.5 ACT00117.1 - 0.09 12.8 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Dimerisation domain HTH_36 PF13730.6 ACT00117.1 - 0.12 12.4 0.1 0.19 11.7 0.0 1.5 2 0 0 2 2 1 0 Helix-turn-helix domain LexA_DNA_bind PF01726.16 ACT00117.1 - 0.12 12.1 0.4 1.6 8.5 0.3 2.3 1 1 1 2 2 2 0 LexA DNA binding domain HTH_29 PF13551.6 ACT00117.1 - 0.13 12.3 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix HTH_28 PF13518.6 ACT00117.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain Catalase PF00199.19 ACT00118.1 - 7.7e-176 584.8 1.1 9.2e-176 584.6 1.1 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ACT00118.1 - 1.7e-17 63.4 0.1 1e-16 60.9 0.0 2.1 2 0 0 2 2 2 1 Catalase-related immune-responsive Response_reg PF00072.24 ACT00119.1 - 1.7e-28 99.0 0.3 3.5e-28 98.0 0.3 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT00119.1 - 1.4e-18 66.5 0.6 6.9e-08 32.4 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT00119.1 - 2.7e-16 59.6 0.8 9e-16 57.9 0.8 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain zf-HC2 PF13490.6 ACT00119.1 - 0.012 15.8 1.7 0.17 12.2 0.1 2.8 2 0 0 2 2 2 0 Putative zinc-finger His_kinase PF06580.13 ACT00120.1 - 6.1e-22 77.7 1.4 2e-21 76.1 1.4 1.9 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACT00120.1 - 8.2e-15 54.9 0.1 1.5e-14 54.1 0.1 1.4 1 0 0 1 1 1 1 HAMP domain dCache_1 PF02743.18 ACT00120.1 - 9.7e-13 48.5 4.8 3.7e-12 46.6 4.8 1.9 1 1 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT00120.1 - 1.8e-06 28.4 0.1 6.2e-06 26.7 0.1 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SBP_bac_1 PF01547.25 ACT00121.1 - 1.5e-37 130.3 11.9 2.8e-37 129.4 11.9 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT00121.1 - 3.3e-30 105.9 9.7 4.4e-30 105.5 9.7 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Secretin_N_2 PF07655.13 ACT00121.1 - 0.85 10.2 9.0 1.8 9.2 9.0 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain BPD_transp_1 PF00528.22 ACT00122.1 - 7.5e-14 51.9 21.2 7.5e-14 51.9 21.2 1.6 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00123.1 - 9.9e-19 67.8 12.3 9.9e-19 67.8 12.3 2.1 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Vut_1 PF02592.15 ACT00123.1 - 0.0043 17.4 5.8 0.0043 17.4 5.8 2.3 2 1 0 2 2 2 1 Putative vitamin uptake transporter Glyco_hydro_127 PF07944.12 ACT00124.1 - 7.1e-165 549.4 0.0 8.2e-165 549.2 0.0 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 TPR_19 PF14559.6 ACT00125.1 - 1.2e-11 45.0 5.5 6.5e-05 23.4 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ACT00125.1 - 3.1e-10 39.4 7.5 0.0012 18.8 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ACT00125.1 - 6.7e-10 38.4 7.6 0.0022 18.0 0.4 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ACT00125.1 - 1.1e-08 35.6 1.5 0.0015 19.2 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_20 PF14561.6 ACT00125.1 - 1.3e-08 35.1 0.3 4.5e-05 23.7 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 ACT00125.1 - 1.8e-07 31.2 2.7 0.00061 19.9 0.4 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ACT00125.1 - 4.4e-07 30.1 3.0 0.019 15.2 0.8 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ACT00125.1 - 1.5e-06 27.8 6.0 0.0026 17.5 0.1 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ACT00125.1 - 1.1e-05 25.6 3.9 0.13 12.5 1.1 2.8 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ACT00125.1 - 0.00017 22.1 5.4 1.4 10.0 0.2 3.9 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 ACT00125.1 - 0.00019 20.7 2.9 0.028 13.7 1.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ACT00125.1 - 0.00036 20.7 0.9 0.36 11.3 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ACT00125.1 - 0.0016 18.9 9.0 0.52 11.1 0.5 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat FAT PF02259.23 ACT00125.1 - 0.0035 16.6 0.1 0.0047 16.2 0.1 1.2 1 0 0 1 1 1 1 FAT domain TPR_21 PF09976.9 ACT00125.1 - 0.02 14.6 1.7 0.06 13.0 0.2 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain Coatomer_E PF04733.14 ACT00125.1 - 0.021 14.2 0.6 1.4 8.3 0.0 2.7 3 0 0 3 3 3 0 Coatomer epsilon subunit NARP1 PF12569.8 ACT00125.1 - 0.025 13.5 2.1 0.71 8.7 0.2 2.0 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 SNAP PF14938.6 ACT00125.1 - 0.044 13.2 0.8 1.6 8.1 0.1 2.7 1 1 2 3 3 3 0 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 ACT00125.1 - 0.059 12.7 0.9 2 7.7 0.2 2.2 2 1 0 2 2 2 0 MalT-like TPR region TPR_10 PF13374.6 ACT00125.1 - 0.078 12.9 0.7 12 5.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ACT00125.1 - 0.1 12.7 2.7 2.4 8.4 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat HATPase_c_5 PF14501.6 ACT00126.1 - 1.6e-16 60.0 0.1 6e-16 58.2 0.1 2.0 1 0 0 1 1 1 1 GHKL domain SPOB_a PF14689.6 ACT00126.1 - 7.1e-11 41.7 1.4 1.7e-10 40.4 1.4 1.7 1 0 0 1 1 1 1 Sensor_kinase_SpoOB-type, alpha-helical domain HATPase_c PF02518.26 ACT00126.1 - 4.7e-06 27.1 0.0 1.2e-05 25.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3365 PF11845.8 ACT00126.1 - 0.83 10.0 2.5 26 5.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) SWIM PF04434.17 ACT00127.1 - 0.00027 20.5 3.6 0.00069 19.2 3.6 1.7 1 0 0 1 1 1 1 SWIM zinc finger SNF2_N PF00176.23 ACT00128.1 - 5.2e-57 193.2 0.0 9.7e-57 192.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3670 PF12419.8 ACT00128.1 - 1.3e-36 125.5 2.7 8.1e-36 122.9 1.0 3.0 2 0 0 2 2 2 1 SNF2 Helicase protein Helicase_C PF00271.31 ACT00128.1 - 2.5e-18 66.4 0.0 5.2e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD_2 PF06733.15 ACT00128.1 - 0.03 13.9 0.7 0.7 9.5 0.2 2.2 2 0 0 2 2 2 0 DEAD_2 ERCC3_RAD25_C PF16203.5 ACT00128.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase SBP_bac_1 PF01547.25 ACT00130.1 - 5e-34 118.7 11.0 7e-34 118.2 11.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT00130.1 - 7.4e-33 114.6 4.5 1e-32 114.1 4.5 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF4969 PF16339.5 ACT00130.1 - 0.0082 16.5 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4969) BPD_transp_1 PF00528.22 ACT00131.1 - 2.8e-11 43.5 34.4 1.6e-09 37.8 34.4 2.4 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component ThrE_2 PF12821.7 ACT00131.1 - 0.014 15.5 4.8 1.3 9.2 0.1 2.6 2 0 0 2 2 2 0 Threonine/Serine exporter, ThrE BPD_transp_1 PF00528.22 ACT00132.1 - 6.2e-16 58.7 16.7 6.2e-16 58.7 16.7 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component NrsF PF06532.11 ACT00132.1 - 6.8 6.3 13.0 0.077 12.7 4.8 2.0 3 0 0 3 3 3 0 Negative regulator of sigma F His_kinase PF06580.13 ACT00133.1 - 4.2e-23 81.5 3.5 4.2e-23 81.5 3.5 2.1 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT00133.1 - 1.8e-15 57.4 1.1 3.5e-15 56.5 1.1 1.5 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT00133.1 - 2.5e-09 37.6 0.0 5.7e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT00133.1 - 1e-05 25.8 0.0 2.8e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 ACT00133.1 - 2.1e-05 24.3 0.0 3.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT00133.1 - 0.00015 21.7 0.0 0.0003 20.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain EF-hand_6 PF13405.6 ACT00133.1 - 0.038 13.9 0.1 0.12 12.4 0.1 1.9 1 0 0 1 1 1 0 EF-hand domain Response_reg PF00072.24 ACT00134.1 - 1.7e-27 95.8 0.0 3.6e-27 94.8 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00134.1 - 4.5e-20 71.7 0.2 1.1e-19 70.5 0.2 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00134.1 - 1.1e-16 60.5 0.3 5.2e-08 32.8 0.1 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Glyco_hydro_3 PF00933.21 ACT00135.1 - 5e-98 328.4 0.0 6.1e-98 328.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ACT00135.1 - 0.0003 20.8 0.6 0.015 15.2 0.0 2.6 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Exonuc_VII_S PF02609.16 ACT00135.1 - 0.25 11.4 2.6 0.45 10.6 0.6 2.4 2 0 0 2 2 2 0 Exonuclease VII small subunit Aminotran_3 PF00202.21 ACT00136.1 - 8.3e-116 387.0 0.0 1e-115 386.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ACT00136.1 - 0.056 12.6 0.0 0.12 11.6 0.0 1.3 1 1 0 1 1 1 0 Aminotransferase class I and II AAA_26 PF13500.6 ACT00137.1 - 1.8e-49 168.3 0.0 2.2e-49 168.0 0.0 1.0 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 ACT00137.1 - 3.7e-09 36.7 0.0 7.5e-09 35.7 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF1611 PF07755.11 ACT00137.1 - 0.0012 18.2 0.2 0.004 16.5 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1611_C) P-loop domain ParA PF10609.9 ACT00137.1 - 0.0026 17.3 0.7 0.015 14.8 0.7 1.9 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase NTPase_1 PF03266.15 ACT00137.1 - 0.19 11.6 0.3 0.84 9.5 0.1 2.0 2 0 0 2 2 2 0 NTPase ResIII PF04851.15 ACT00137.1 - 0.22 11.5 0.1 0.36 10.8 0.1 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ArsA_ATPase PF02374.15 ACT00137.1 - 0.36 10.0 1.8 1.7 7.7 0.9 2.0 2 0 0 2 2 2 0 Anion-transporting ATPase Radical_SAM PF04055.21 ACT00138.1 - 3.4e-15 56.8 0.3 8.8e-15 55.5 0.3 1.6 1 1 0 1 1 1 1 Radical SAM superfamily BATS PF06968.13 ACT00138.1 - 3.3e-14 52.8 0.0 1.4e-13 50.8 0.0 2.0 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Ligase_CoA PF00549.19 ACT00138.1 - 6.5e-06 26.0 0.0 0.069 13.0 0.1 2.3 2 0 0 2 2 2 2 CoA-ligase HMGL-like PF00682.19 ACT00138.1 - 0.019 14.5 0.1 0.026 14.1 0.1 1.2 1 0 0 1 1 1 0 HMGL-like His_biosynth PF00977.21 ACT00138.1 - 0.035 13.6 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 Histidine biosynthesis protein Aminotran_1_2 PF00155.21 ACT00139.1 - 1.9e-63 214.8 0.0 2.2e-63 214.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ACT00139.1 - 0.0016 17.8 0.0 0.0026 17.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase OKR_DC_1 PF01276.20 ACT00139.1 - 0.0044 15.8 0.0 0.0063 15.3 0.0 1.3 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Cys_Met_Meta_PP PF01053.20 ACT00139.1 - 0.027 13.0 0.0 0.037 12.6 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Abhydrolase_6 PF12697.7 ACT00140.1 - 2.6e-12 47.8 1.0 1.2e-11 45.6 0.2 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ACT00140.1 - 2e-10 40.8 0.0 1.9e-07 31.0 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ACT00140.1 - 1.1e-09 37.9 0.0 1.6e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ACT00140.1 - 0.0014 18.2 0.0 0.086 12.3 0.0 2.4 2 1 0 2 2 2 1 Prolyl oligopeptidase family Thioesterase PF00975.20 ACT00140.1 - 0.0027 17.9 0.0 0.0042 17.2 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_2 PF02230.16 ACT00140.1 - 0.01 15.7 0.0 1 9.1 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase UPF0227 PF05728.12 ACT00140.1 - 0.015 15.2 0.0 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Abhydrolase_4 PF08386.10 ACT00140.1 - 0.031 14.4 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein DLH PF01738.18 ACT00140.1 - 0.14 11.7 0.0 7.3 6.1 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 ACT00140.1 - 0.19 11.5 0.0 0.43 10.3 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family Methyltransf_23 PF13489.6 ACT00141.1 - 3.3e-22 79.1 0.0 4.7e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT00141.1 - 2.5e-21 76.2 0.0 9.2e-21 74.4 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT00141.1 - 1.2e-20 73.9 0.0 3.9e-20 72.3 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT00141.1 - 2.9e-19 69.3 0.0 4.1e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT00141.1 - 5.9e-19 68.7 0.0 1.1e-18 67.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ACT00141.1 - 1.2e-12 47.6 0.0 1.7e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 ACT00141.1 - 1.1e-09 38.1 0.0 1.5e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain NodS PF05401.11 ACT00141.1 - 3.1e-08 33.5 0.0 4.4e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_2 PF00891.18 ACT00141.1 - 1.9e-07 30.6 0.0 2.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_4 PF02390.17 ACT00141.1 - 2.9e-07 30.1 0.0 9.6e-06 25.2 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_29 PF03141.16 ACT00141.1 - 1.9e-06 26.7 0.0 2.5e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PCMT PF01135.19 ACT00141.1 - 0.00022 21.0 0.0 0.00032 20.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 ACT00141.1 - 0.00046 20.3 0.0 0.0017 18.5 0.0 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase RrnaAD PF00398.20 ACT00141.1 - 0.00053 19.1 0.0 0.00082 18.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DUF938 PF06080.12 ACT00141.1 - 0.001 18.8 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) MetW PF07021.12 ACT00141.1 - 0.0011 18.6 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_24 PF13578.6 ACT00141.1 - 0.0014 19.6 0.0 0.0052 17.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 ACT00141.1 - 0.0026 17.8 0.0 0.0038 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ACT00141.1 - 0.0058 16.0 0.0 0.0073 15.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_PK PF05891.12 ACT00141.1 - 0.0068 16.0 0.0 0.01 15.4 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_9 PF08003.11 ACT00141.1 - 0.013 14.5 0.0 0.017 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_33 PF10017.9 ACT00141.1 - 0.015 14.5 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Methyltransf_16 PF10294.9 ACT00141.1 - 0.027 14.2 0.0 0.04 13.7 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_7 PF03492.15 ACT00141.1 - 0.13 11.5 0.0 5 6.2 0.1 2.7 2 1 0 3 3 3 0 SAM dependent carboxyl methyltransferase Methyltransf_5 PF01795.19 ACT00141.1 - 0.16 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 MraW methylase family HAD_2 PF13419.6 ACT00142.1 - 1.2e-30 106.9 0.0 1.4e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT00142.1 - 1.1e-08 35.6 0.1 6.1e-08 33.2 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT00142.1 - 7.9e-06 25.8 0.0 1.8e-05 24.7 0.0 1.6 2 0 0 2 2 2 1 HAD-hyrolase-like NIF PF03031.18 ACT00142.1 - 0.0027 17.5 0.1 0.0037 17.0 0.1 1.5 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase NT5C PF06941.12 ACT00142.1 - 0.25 11.2 1.4 0.49 10.3 0.5 2.0 2 1 0 2 2 2 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) MerR_1 PF13411.6 ACT00143.1 - 4.7e-19 68.2 0.2 7.2e-19 67.7 0.2 1.3 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT00143.1 - 1.9e-12 46.7 0.0 3.2e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT00143.1 - 7.4e-11 42.4 0.0 7.4e-11 42.4 0.0 1.9 3 0 0 3 3 3 1 MerR, DNA binding Kdo_hydroxy PF11004.8 ACT00143.1 - 0.029 13.7 0.1 0.041 13.1 0.1 1.2 1 0 0 1 1 1 0 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase adh_short PF00106.25 ACT00144.1 - 1.7e-19 70.1 0.0 2.9e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT00144.1 - 2.9e-11 43.6 0.1 4.1e-11 43.1 0.1 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 ACT00144.1 - 1.1e-10 41.4 0.0 1.9e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ribosomal_L12 PF00542.19 ACT00144.1 - 0.086 13.2 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain NAD_binding_10 PF13460.6 ACT00145.1 - 5.6e-28 98.1 0.0 6.3e-28 97.9 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT00145.1 - 4.9e-21 75.4 0.0 2.6e-20 73.0 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family Epimerase PF01370.21 ACT00145.1 - 1.1e-08 34.8 0.0 3.8e-08 33.1 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ACT00145.1 - 0.00032 19.8 0.1 0.00052 19.1 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_2 PF03446.15 ACT00145.1 - 0.0033 17.6 0.1 0.0065 16.7 0.0 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase GDP_Man_Dehyd PF16363.5 ACT00145.1 - 0.0045 16.4 0.0 0.0085 15.5 0.0 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ACT00145.1 - 0.005 16.0 0.0 1.1 8.4 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein DapB_N PF01113.20 ACT00145.1 - 0.024 14.8 0.1 0.042 14.0 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 ACT00145.1 - 0.024 14.1 0.0 2.1 7.7 0.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase TrkA_N PF02254.18 ACT00145.1 - 0.059 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain adh_short_C2 PF13561.6 ACT00145.1 - 0.066 12.8 0.0 0.18 11.4 0.0 1.6 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase NAD_binding_7 PF13241.6 ACT00145.1 - 0.13 12.7 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 ACT00145.1 - 0.13 11.5 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain RibD_C PF01872.17 ACT00146.1 - 4.1e-12 46.4 0.0 2.4e-11 43.9 0.0 1.9 1 1 0 1 1 1 1 RibD C-terminal domain DHFR_1 PF00186.19 ACT00146.1 - 1e-08 35.1 0.0 1.3e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase Abhydrolase_1 PF00561.20 ACT00147.1 - 4.6e-22 78.9 0.1 4.8e-21 75.6 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACT00147.1 - 4.4e-20 73.2 0.2 6.2e-20 72.8 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACT00147.1 - 9.6e-12 44.7 0.0 1.3e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 ACT00147.1 - 2e-05 23.8 0.0 4.8e-05 22.5 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF1057) Ndr PF03096.14 ACT00147.1 - 0.00096 17.9 0.0 0.0028 16.4 0.0 1.7 1 1 0 1 1 1 1 Ndr family HxlR PF01638.17 ACT00148.1 - 7.6e-30 102.6 0.2 1e-29 102.2 0.2 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix MarR_2 PF12802.7 ACT00148.1 - 0.00013 21.8 0.0 0.00019 21.2 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 ACT00148.1 - 0.00068 19.6 0.1 0.00092 19.2 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_12 PF08461.10 ACT00148.1 - 0.0083 16.1 0.1 0.015 15.2 0.1 1.4 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain MarR PF01047.22 ACT00148.1 - 0.018 14.9 0.1 0.027 14.4 0.1 1.3 1 0 0 1 1 1 0 MarR family HTH_5 PF01022.20 ACT00148.1 - 0.025 14.4 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 ACT00148.1 - 0.038 13.6 0.0 0.074 12.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding PadR PF03551.14 ACT00148.1 - 0.039 13.9 0.2 0.067 13.2 0.2 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family LexA_DNA_bind PF01726.16 ACT00148.1 - 0.067 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 LexA DNA binding domain Replic_Relax PF13814.6 ACT00148.1 - 0.067 13.2 0.0 0.073 13.1 0.0 1.2 1 0 0 1 1 1 0 Replication-relaxation B-block_TFIIIC PF04182.12 ACT00148.1 - 0.074 13.2 0.0 0.086 13.0 0.0 1.2 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC DUF4423 PF14394.6 ACT00148.1 - 0.17 11.5 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Abhydrolase_1 PF00561.20 ACT00149.1 - 7.5e-15 55.3 0.0 1.2e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACT00149.1 - 0.00022 21.9 0.0 0.00028 21.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 ACT00149.1 - 0.0022 17.7 0.1 0.0043 16.7 0.1 1.5 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ACT00149.1 - 0.0088 15.3 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LysR_substrate PF03466.20 ACT00150.1 - 5.7e-49 166.3 0.0 7.1e-49 166.0 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT00150.1 - 8.8e-19 67.2 1.4 1.4e-18 66.6 0.4 1.9 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family DUF4745 PF15923.5 ACT00150.1 - 0.13 12.2 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4745) DUF4288 PF14119.6 ACT00150.1 - 0.17 12.3 0.0 0.4 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) VWA_2 PF13519.6 ACT00151.1 - 7.6e-08 33.0 0.0 4.1e-07 30.6 0.0 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ACT00151.1 - 6.1e-06 26.6 0.0 0.055 13.7 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 ACT00151.1 - 0.028 13.8 0.0 2.6 7.4 0.0 2.1 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein PP2C_2 PF13672.6 ACT00152.1 - 1.8e-06 27.8 0.0 2.4e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C UPF0175 PF03683.13 ACT00152.1 - 0.21 11.3 0.0 0.39 10.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0175) APH PF01636.23 ACT00153.1 - 0.0005 20.1 1.5 0.99 9.3 0.0 3.0 2 1 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.22 ACT00153.1 - 0.0051 16.4 0.2 0.0051 16.4 0.2 2.1 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 ACT00153.1 - 0.01 15.4 0.3 0.01 15.4 0.3 2.2 3 0 0 3 3 3 0 Choline/ethanolamine kinase Pkinase PF00069.25 ACT00153.1 - 0.026 13.9 0.0 0.066 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein kinase domain ABC_cobalt PF09819.9 ACT00153.1 - 0.12 12.5 1.1 0.21 11.7 1.1 1.3 1 0 0 1 1 1 0 ABC-type cobalt transport system, permease component Aldo_ket_red PF00248.21 ACT00154.1 - 1.9e-58 198.0 0.0 2.4e-58 197.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family NUDIX PF00293.28 ACT00155.1 - 1.4e-19 70.4 0.0 1.5e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Bac_rhamnosid6H PF17389.2 ACT00156.1 - 1.2e-56 192.5 1.5 1.5e-56 192.1 1.5 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 ACT00156.1 - 2.2e-11 43.4 0.0 5e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid PF05592.11 ACT00156.1 - 5.3e-08 32.8 0.0 1.4e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_N PF08531.10 ACT00156.1 - 2.5e-07 30.7 0.7 2.1e-06 27.7 0.7 2.2 1 1 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Trehalase PF01204.18 ACT00156.1 - 5.7e-07 28.7 0.0 9.3e-07 28.0 0.0 1.2 1 0 0 1 1 1 1 Trehalase BetaGal_dom4_5 PF13364.6 ACT00156.1 - 0.0012 19.4 0.0 0.0034 17.9 0.0 1.7 1 0 0 1 1 1 1 Beta-galactosidase jelly roll domain GDE_C PF06202.14 ACT00156.1 - 0.034 13.1 0.5 0.079 11.9 0.5 1.5 1 1 0 1 1 1 0 Amylo-alpha-1,6-glucosidase BPD_transp_1 PF00528.22 ACT00157.1 - 4.9e-16 59.0 11.7 4.9e-16 59.0 11.7 1.6 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component MNHE PF01899.16 ACT00157.1 - 0.039 13.7 2.5 0.094 12.5 2.5 1.7 1 0 0 1 1 1 0 Na+/H+ ion antiporter subunit BPD_transp_1 PF00528.22 ACT00158.1 - 4.5e-16 59.1 25.7 6.6e-16 58.6 20.2 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component ERO1 PF04137.15 ACT00158.1 - 0.19 10.9 0.0 0.26 10.4 0.0 1.1 1 0 0 1 1 1 0 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) SBP_bac_1 PF01547.25 ACT00159.1 - 1.3e-11 45.0 8.8 3.9e-11 43.5 8.8 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT00159.1 - 0.0039 17.8 0.5 0.0039 17.8 0.5 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) DUF1801 PF08818.11 ACT00159.1 - 0.45 11.1 2.6 0.78 10.3 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DU1801) HTH_18 PF12833.7 ACT00160.1 - 8.9e-21 74.0 0.0 2.1e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00160.1 - 2.7e-18 65.6 0.0 1.7e-08 34.3 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family dCache_1 PF02743.18 ACT00160.1 - 8.2e-18 65.1 2.0 8.2e-18 65.1 2.0 1.9 2 0 0 2 2 2 1 Cache domain GGDEF_2 PF17853.1 ACT00160.1 - 1.9e-09 37.8 0.1 1.2e-08 35.2 0.0 2.2 2 0 0 2 2 2 1 GGDEF-like domain PHA-1 PF06542.11 ACT00160.1 - 0.0064 15.4 0.5 0.011 14.7 0.5 1.2 1 0 0 1 1 1 1 Regulator protein PHA-1 Sigma70_r4 PF04545.16 ACT00160.1 - 0.012 15.1 3.1 1.1 8.8 0.0 3.5 3 0 0 3 3 3 0 Sigma-70, region 4 Chlorophyllase PF07224.11 ACT00160.1 - 0.056 12.5 0.5 0.31 10.0 0.0 2.1 2 0 0 2 2 2 0 Chlorophyllase DUF3671 PF12420.8 ACT00160.1 - 0.49 10.5 2.2 0.79 9.8 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function Alpha_L_fucos PF01120.17 ACT00161.1 - 2.6e-86 290.3 1.6 3.2e-86 290.0 1.6 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 ACT00161.1 - 0.00012 22.6 0.0 0.0003 21.3 0.0 1.7 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain Alpha_L_fucos PF01120.17 ACT00162.1 - 4.8e-90 302.5 0.0 5.7e-90 302.3 0.0 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL6 PF14871.6 ACT00162.1 - 0.0022 18.1 0.0 0.0088 16.2 0.0 1.9 2 0 0 2 2 2 1 Hypothetical glycosyl hydrolase 6 Methyltransf_24 PF13578.6 ACT00162.1 - 0.064 14.3 0.0 0.16 13.0 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain CBM9_1 PF06452.11 ACT00163.1 - 2.2e-12 47.3 0.8 4.5e-12 46.3 0.8 1.7 1 1 0 1 1 1 1 Carbohydrate family 9 binding domain-like CBM9_2 PF16011.5 ACT00163.1 - 3.2e-05 23.7 0.0 5.5e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate-binding family 9 UB2H PF14814.6 ACT00163.1 - 0.087 12.9 0.2 0.23 11.5 0.2 1.6 1 0 0 1 1 1 0 Bifunctional transglycosylase second domain Transglut_core PF01841.19 ACT00164.1 - 2.4e-22 79.5 0.2 5.4e-15 55.8 0.7 2.7 2 0 0 2 2 2 2 Transglutaminase-like superfamily Big_1 PF02369.16 ACT00164.1 - 0.00014 21.8 0.0 0.00024 21.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 1) Invasin_D3 PF09134.10 ACT00164.1 - 0.096 13.0 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Invasin, domain 3 Transglut_core3 PF13471.6 ACT00164.1 - 0.14 12.1 0.6 0.48 10.3 0.6 1.9 1 0 0 1 1 1 0 Transglutaminase-like superfamily Glyco_hydro_18 PF00704.28 ACT00165.1 - 2.5e-77 260.7 0.0 3.1e-77 260.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 AP_endonuc_2 PF01261.24 ACT00166.1 - 2.2e-20 73.0 0.0 3.2e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Sigma70_r4_2 PF08281.12 ACT00167.1 - 0.18 11.5 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 Sigma-70, region 4 DinB_2 PF12867.7 ACT00168.1 - 1.7e-18 67.4 0.2 2e-18 67.1 0.2 1.1 1 0 0 1 1 1 1 DinB superfamily DUF1569 PF07606.11 ACT00168.1 - 0.02 14.9 0.4 0.92 9.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1569) HD_2 PF12917.7 ACT00170.1 - 1.5e-72 243.2 0.0 1.7e-72 243.0 0.0 1.0 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD_3 PF13023.6 ACT00170.1 - 2.1e-19 70.0 0.0 2.7e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.22 ACT00170.1 - 0.00015 22.0 1.0 0.00053 20.2 1.0 1.9 1 1 0 1 1 1 1 HD domain HDOD PF08668.12 ACT00170.1 - 0.057 12.9 0.0 0.079 12.4 0.0 1.2 1 0 0 1 1 1 0 HDOD domain DUF2294 PF10057.9 ACT00171.1 - 8.5e-28 96.7 0.2 6.6e-19 68.1 0.0 2.1 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2294) HTH_18 PF12833.7 ACT00171.1 - 0.18 12.1 0.0 2.1 8.7 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain DUF2294 PF10057.9 ACT00172.1 - 4.5e-30 104.0 0.1 1.2e-19 70.5 0.0 2.1 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2294) UPF0370 PF13980.6 ACT00172.1 - 0.12 12.5 0.1 0.28 11.3 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) HATPase_c PF02518.26 ACT00173.1 - 5.2e-22 78.5 0.0 1.3e-21 77.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 ACT00173.1 - 2.4e-18 66.2 0.0 3.4e-08 33.5 0.0 3.0 3 0 0 3 3 3 2 PAS fold PAS_4 PF08448.10 ACT00173.1 - 1.7e-17 63.6 0.0 3.8e-10 40.0 0.0 2.3 2 0 0 2 2 2 2 PAS fold HisKA PF00512.25 ACT00173.1 - 3.5e-14 52.6 0.1 8e-14 51.4 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 ACT00173.1 - 2e-13 50.5 0.0 2.3e-07 31.0 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.7 ACT00173.1 - 9e-12 44.7 0.0 8.5e-07 28.9 0.0 2.8 3 0 0 3 3 3 2 PAS domain PAS_3 PF08447.12 ACT00173.1 - 1.4e-07 31.6 0.0 3.2e-06 27.3 0.0 2.4 2 0 0 2 2 2 1 PAS fold HATPase_c_5 PF14501.6 ACT00173.1 - 0.00012 22.0 0.0 0.00028 20.8 0.0 1.6 1 0 0 1 1 1 1 GHKL domain MEKHLA PF08670.11 ACT00173.1 - 0.0029 17.5 0.0 0.045 13.6 0.0 2.3 2 0 0 2 2 2 1 MEKHLA domain HPTransfase PF10090.9 ACT00173.1 - 0.031 14.1 0.0 1.6 8.5 0.0 2.7 3 0 0 3 3 3 0 Histidine phosphotransferase C-terminal domain HATPase_c_2 PF13581.6 ACT00173.1 - 0.054 13.5 0.0 0.34 10.9 0.0 2.1 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain SSTK-IP PF15836.5 ACT00173.1 - 0.085 13.0 0.1 9.1 6.4 0.0 2.4 2 0 0 2 2 2 0 SSTK-interacting protein, TSSK6-activating co-chaperone protein SBF PF01758.16 ACT00174.1 - 5.9e-19 68.5 17.5 5.9e-19 68.5 17.5 2.1 2 1 0 2 2 2 1 Sodium Bile acid symporter family HATPase_c PF02518.26 ACT00175.1 - 3e-32 111.4 0.2 8.1e-32 110.1 0.2 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT00175.1 - 2.2e-19 69.3 0.5 1.3e-18 66.8 0.0 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT00175.1 - 1.8e-13 50.7 0.1 6e-13 49.0 0.1 1.9 1 0 0 1 1 1 1 HAMP domain PAS_4 PF08448.10 ACT00175.1 - 2.3e-12 47.1 0.0 4.1e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 ACT00175.1 - 5.6e-12 45.7 0.1 1.2e-11 44.6 0.1 1.6 1 0 0 1 1 1 1 PAS fold sCache_like PF16736.5 ACT00175.1 - 6.6e-10 39.1 1.7 6.9e-07 29.4 0.0 3.4 3 0 0 3 3 3 1 Single Cache-like PAS_9 PF13426.7 ACT00175.1 - 2.6e-07 30.8 0.0 1.3e-06 28.5 0.0 2.3 2 0 0 2 2 1 1 PAS domain dCache_1 PF02743.18 ACT00175.1 - 8.1e-05 22.5 0.1 0.0026 17.6 0.0 2.6 3 0 0 3 3 3 1 Cache domain HATPase_c_3 PF13589.6 ACT00175.1 - 0.00052 19.8 0.1 0.0017 18.2 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_8 PF13188.7 ACT00175.1 - 0.00083 19.3 0.0 0.0022 18.0 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_7 PF12860.7 ACT00175.1 - 0.00083 19.5 0.7 0.0037 17.4 0.1 2.5 2 1 0 2 2 2 1 PAS fold PAS_10 PF13596.6 ACT00175.1 - 0.0029 18.2 0.0 0.0089 16.6 0.0 1.9 1 0 0 1 1 1 1 PAS domain DUF2062 PF09835.9 ACT00175.1 - 0.005 16.7 0.1 0.017 15.0 0.0 1.9 2 0 0 2 2 1 1 Uncharacterized protein conserved in bacteria (DUF2062) Peptidase_M56 PF05569.11 ACT00175.1 - 0.013 14.7 0.3 0.025 13.8 0.3 1.4 1 0 0 1 1 1 0 BlaR1 peptidase M56 LAGLIDADG_WhiA PF14527.6 ACT00175.1 - 0.021 14.9 0.5 0.34 11.0 0.4 2.4 2 0 0 2 2 2 0 WhiA LAGLIDADG-like domain Baculo_PEP_C PF04513.12 ACT00175.1 - 0.047 13.7 0.1 0.21 11.6 0.1 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SbcD_C PF12320.8 ACT00175.1 - 0.1 12.9 3.3 4.7 7.6 0.5 3.4 3 0 0 3 3 3 0 Type 5 capsule protein repressor C-terminal domain DUF2634 PF10934.8 ACT00175.1 - 0.12 12.5 0.0 0.34 11.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2634) CorA PF01544.18 ACT00175.1 - 1.7 7.9 6.5 0.32 10.3 1.8 2.2 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein UPF0542 PF15086.6 ACT00175.1 - 8.9 6.3 6.0 1.5e+02 2.4 6.0 2.4 1 1 0 1 1 1 0 Uncharacterised protein family UPF0542 Response_reg PF00072.24 ACT00176.1 - 6.2e-30 103.6 0.0 9.5e-30 103.1 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT00176.1 - 2e-23 82.2 0.0 4.6e-23 81.1 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal GerE PF00196.19 ACT00176.1 - 0.032 13.8 0.1 0.39 10.3 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_11 PF08279.12 ACT00176.1 - 0.097 12.6 0.1 0.27 11.2 0.1 1.8 1 0 0 1 1 1 0 HTH domain HTH_18 PF12833.7 ACT00177.1 - 7.6e-16 58.2 0.0 1.5e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00177.1 - 1e-13 51.0 0.1 4.4e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT00177.1 - 4.2e-11 42.9 0.3 7e-11 42.2 0.3 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT00177.1 - 4.6e-10 39.1 0.1 8.5e-10 38.2 0.1 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 ACT00177.1 - 0.0025 17.6 0.0 2 8.1 0.0 2.1 2 0 0 2 2 2 2 Cupin Cupin_3 PF05899.12 ACT00177.1 - 0.0086 15.7 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) EutQ PF06249.12 ACT00177.1 - 0.029 14.1 0.0 0.1 12.4 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation protein EutQ MannoseP_isomer PF01050.18 ACT00177.1 - 0.083 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase 2-Hacid_dh_C PF02826.19 ACT00178.1 - 2.7e-65 219.0 0.0 4.5e-65 218.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ACT00178.1 - 5.9e-29 100.4 0.0 6.8e-29 100.2 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ACT00178.1 - 7.6e-07 29.4 0.0 2.8e-06 27.6 0.0 1.9 1 1 1 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACT00178.1 - 0.0034 17.9 0.0 0.012 16.1 0.0 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 ACT00178.1 - 0.021 14.4 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Pyridox_ox_2 PF12900.7 ACT00179.1 - 1.2e-26 93.4 0.0 1.3e-26 93.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 ACT00179.1 - 4.9e-06 26.6 0.0 8.3e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.12 ACT00179.1 - 0.14 11.9 0.0 0.48 10.1 0.0 2.0 1 1 0 1 1 1 0 Putative FMN-binding domain GIY-YIG PF01541.24 ACT00180.1 - 2.5e-09 37.3 0.9 3.7e-09 36.7 0.9 1.2 1 0 0 1 1 1 1 GIY-YIG catalytic domain Dak1 PF02733.17 ACT00180.1 - 0.23 10.3 0.0 0.25 10.2 0.0 1.1 1 0 0 1 1 1 0 Dak1 domain Glyco_hydro_9 PF00759.19 ACT00181.1 - 5.4e-92 309.4 0.2 6.2e-92 309.2 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 CelD_N PF02927.14 ACT00181.1 - 1.7e-16 60.9 0.0 3.1e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Cellulase N-terminal ig-like domain DUF4079 PF13301.6 ACT00181.1 - 0.14 12.3 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) Acetyltransf_1 PF00583.25 ACT00182.1 - 4.1e-10 39.9 0.1 3.8e-09 36.8 0.1 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT00182.1 - 7.3e-09 35.6 0.0 2.4e-08 33.9 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT00182.1 - 1.8e-08 34.7 0.1 3.5e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT00182.1 - 0.00017 21.5 0.0 0.00034 20.5 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ACT00182.1 - 0.00082 20.1 0.1 0.0017 19.1 0.1 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT00182.1 - 0.0089 16.1 0.0 0.21 11.7 0.0 2.6 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACT00182.1 - 0.031 14.4 0.0 0.073 13.2 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.6 ACT00182.1 - 0.16 11.6 0.0 1.9 8.2 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Peptidase_M3 PF01432.20 ACT00183.1 - 3.9e-28 98.9 4.7 1.5e-20 73.9 1.4 2.3 2 0 0 2 2 2 2 Peptidase family M3 DUF3235 PF11574.8 ACT00183.1 - 0.045 14.6 0.1 0.35 11.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3235) M20_dimer PF07687.14 ACT00184.1 - 1.1e-08 34.9 0.0 2.6e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ACT00184.1 - 6.3e-05 22.8 0.0 0.0001 22.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 HTH_18 PF12833.7 ACT00185.1 - 2.6e-20 72.5 0.1 4.1e-20 71.8 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00185.1 - 8.2e-18 64.0 0.0 9.5e-08 32.0 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT00185.1 - 4.2e-15 55.9 0.1 6.8e-15 55.2 0.1 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT00185.1 - 3.1e-05 23.6 0.0 5.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Cupin domain HTH_Crp_2 PF13545.6 ACT00185.1 - 0.0069 16.3 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain MarR_2 PF12802.7 ACT00185.1 - 0.014 15.3 0.0 0.93 9.4 0.0 2.3 2 0 0 2 2 2 0 MarR family MarR PF01047.22 ACT00185.1 - 0.041 13.8 0.0 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 MarR family ArsR PF09824.9 ACT00185.1 - 0.08 12.5 0.1 0.41 10.2 0.0 2.0 3 0 0 3 3 3 0 ArsR transcriptional regulator Glyco_hydro_42 PF02449.15 ACT00186.1 - 2.1e-149 497.9 7.3 2.6e-149 497.7 7.3 1.1 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_42M PF08532.10 ACT00186.1 - 1.5e-71 240.2 0.0 2.6e-71 239.4 0.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase trimerisation domain Glyco_hydro_42C PF08533.10 ACT00186.1 - 5.9e-10 38.7 0.1 1e-09 37.9 0.1 1.4 1 0 0 1 1 1 1 Beta-galactosidase C-terminal domain Glyco_hydro_14 PF01373.17 ACT00186.1 - 0.00053 19.0 0.2 0.0012 17.9 0.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 Cellulase PF00150.18 ACT00186.1 - 0.0072 15.8 0.2 0.016 14.6 0.2 1.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4434 PF14488.6 ACT00186.1 - 0.035 14.1 0.4 0.1 12.6 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4434) tRNA-synt_1b PF00579.25 ACT00187.1 - 6.7e-82 275.1 0.0 8.4e-82 274.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 ACT00187.1 - 4.7e-07 29.4 0.0 9.5e-07 28.4 0.0 1.5 1 0 0 1 1 1 1 S4 domain Gmad2 PF10648.9 ACT00189.1 - 4.4e-14 52.5 0.0 8.4e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin-like domain of bacterial spore germination Cu_amine_oxidN1 PF07833.11 ACT00189.1 - 1.1e-06 29.0 0.0 1.8e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase N-terminal domain MCPsignal PF00015.21 ACT00191.1 - 3.8e-28 98.5 21.5 1.7e-26 93.1 21.5 2.2 1 1 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain CBS PF00571.28 ACT00191.1 - 6.1e-05 23.4 0.1 0.00035 21.0 0.1 2.1 2 0 0 2 2 2 1 CBS domain FUSC PF04632.12 ACT00191.1 - 0.48 8.9 5.0 0.65 8.5 5.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family PIN_8 PF18476.1 ACT00191.1 - 0.84 9.4 4.2 1 9.2 0.2 2.1 2 0 0 2 2 2 0 PIN like domain DUF948 PF06103.11 ACT00191.1 - 1.8 8.9 9.7 5.7 7.3 0.1 3.7 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF4559 PF15112.6 ACT00191.1 - 3.8 7.1 6.2 0.73 9.4 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) ABC_tran PF00005.27 ACT00192.1 - 8.6e-32 110.5 0.0 1.5e-31 109.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00192.1 - 3.2e-09 37.0 0.1 0.00037 20.4 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT00192.1 - 1.3e-06 28.0 0.4 0.014 14.9 0.2 2.6 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT00192.1 - 2e-05 24.9 0.3 0.00015 22.1 0.3 2.0 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT00192.1 - 9.3e-05 22.4 0.1 0.00059 19.8 0.0 2.2 2 1 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 ACT00192.1 - 0.00019 21.2 0.0 0.00033 20.5 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT00192.1 - 0.00025 20.7 0.0 0.00055 19.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT00192.1 - 0.00043 20.7 0.2 0.003 18.0 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ACT00192.1 - 0.0011 19.5 0.3 0.0054 17.3 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ACT00192.1 - 0.0025 17.6 0.3 0.38 10.4 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ACT00192.1 - 0.0031 17.8 0.1 0.039 14.2 0.1 2.5 3 0 0 3 3 3 1 AAA domain Rad17 PF03215.15 ACT00192.1 - 0.0043 17.0 0.0 0.0092 15.9 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain ABC_ATPase PF09818.9 ACT00192.1 - 0.0043 15.9 0.1 0.91 8.2 0.0 2.2 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_33 PF13671.6 ACT00192.1 - 0.0091 16.2 0.0 0.02 15.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 ACT00192.1 - 0.013 14.6 0.0 0.02 14.1 0.0 1.3 1 1 0 1 1 1 0 NB-ARC domain AAA PF00004.29 ACT00192.1 - 0.014 15.9 0.3 0.27 11.6 0.2 2.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 ACT00192.1 - 0.017 14.7 0.0 0.06 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ACT00192.1 - 0.017 15.7 0.0 0.034 14.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain PRK PF00485.18 ACT00192.1 - 0.019 14.7 0.1 0.5 10.1 0.0 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Adeno_IVa2 PF02456.15 ACT00192.1 - 0.036 12.9 0.2 0.13 11.0 0.1 1.8 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_5 PF07728.14 ACT00192.1 - 0.049 13.6 0.3 0.59 10.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ACT00192.1 - 0.054 13.2 0.3 6.9 6.4 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein DeoRC PF00455.22 ACT00192.1 - 0.082 12.8 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 DeoR C terminal sensor domain RNA_helicase PF00910.22 ACT00192.1 - 0.092 13.1 0.1 0.25 11.7 0.0 1.8 2 0 0 2 2 2 0 RNA helicase MMR_HSR1 PF01926.23 ACT00192.1 - 0.14 12.2 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase PhoU PF01895.19 ACT00193.1 - 2.1e-45 153.1 4.8 4.5e-23 81.5 0.4 2.1 2 0 0 2 2 2 2 PhoU domain Csm1_N PF18504.1 ACT00193.1 - 0.047 14.0 0.4 0.32 11.4 0.0 2.1 2 0 0 2 2 2 0 Csm1 N-terminal domain DUF1902 PF08972.11 ACT00193.1 - 0.073 13.1 0.6 0.17 11.9 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) DUF2046 PF09755.9 ACT00193.1 - 0.092 12.0 0.5 0.28 10.4 0.1 1.8 1 1 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) SLH PF00395.20 ACT00194.1 - 1.4e-40 137.0 4.0 5.3e-13 48.7 0.1 3.9 3 0 0 3 3 3 3 S-layer homology domain Cadherin-like PF12733.7 ACT00194.1 - 1.5e-16 60.7 10.2 1.3e-09 38.5 2.0 3.0 3 0 0 3 3 3 2 Cadherin-like beta sandwich domain DUF1410 PF07198.11 ACT00194.1 - 0.2 12.2 2.0 0.79 10.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1410) DNA_pol_A PF00476.20 ACT00195.1 - 2.4e-158 527.1 0.0 3.5e-158 526.6 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A 5_3_exonuc_N PF02739.16 ACT00195.1 - 3.8e-53 179.6 0.0 6.4e-53 178.9 0.0 1.4 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 ACT00195.1 - 1.5e-32 112.1 0.1 1.8e-31 108.6 0.1 2.8 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 ACT00195.1 - 0.0012 19.4 0.0 0.004 17.7 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 ACT00195.1 - 0.0084 16.2 0.0 0.048 13.8 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif Taq-exonuc PF09281.10 ACT00195.1 - 0.093 12.7 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Taq polymerase, exonuclease Fapy_DNA_glyco PF01149.24 ACT00196.1 - 1e-33 116.4 0.4 1.5e-33 115.8 0.4 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 ACT00196.1 - 1.3e-27 95.6 0.0 1.9e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain zf-FPG_IleRS PF06827.14 ACT00196.1 - 1.1e-07 31.5 1.0 1.1e-07 31.5 1.0 1.9 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS FbpA PF05833.11 ACT00196.1 - 0.003 16.4 0.0 0.0038 16.0 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Mntp PF02659.15 ACT00197.1 - 2.8e-18 66.1 23.9 7.6e-10 38.7 5.9 2.1 2 0 0 2 2 2 2 Putative manganese efflux pump CopD PF05425.13 ACT00197.1 - 0.0056 17.1 0.4 0.0056 17.1 0.4 2.6 3 1 1 4 4 4 1 Copper resistance protein D EF-hand_5 PF13202.6 ACT00197.1 - 0.031 13.8 0.0 0.064 12.8 0.0 1.5 1 0 0 1 1 1 0 EF hand Dockerin_1 PF00404.18 ACT00197.1 - 0.035 14.3 0.0 0.055 13.7 0.0 1.3 1 0 0 1 1 1 0 Dockerin type I domain PhoR PF11808.8 ACT00197.1 - 3.3 8.2 7.9 0.84 10.1 1.1 2.7 2 1 1 3 3 3 0 Phosphate regulon sensor protein PhoR CoaE PF01121.20 ACT00198.1 - 6.5e-61 205.1 0.3 7.3e-61 205.0 0.3 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 ACT00198.1 - 0.00068 20.2 0.4 0.0045 17.5 0.3 2.1 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ACT00198.1 - 0.00089 19.5 1.5 0.0064 16.7 0.5 2.5 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 ACT00198.1 - 0.0015 18.7 0.0 0.0039 17.3 0.0 1.8 1 1 1 2 2 2 1 AAA domain Hpr_kinase_C PF07475.12 ACT00198.1 - 0.011 15.3 0.1 0.019 14.5 0.1 1.5 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain EspB PF05802.11 ACT00198.1 - 0.076 13.0 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Enterobacterial EspB protein SLT PF01464.20 ACT00199.1 - 2.6e-28 98.0 0.0 3.5e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase SLT domain SLT_2 PF13406.6 ACT00199.1 - 6.6e-08 32.1 0.6 0.0011 18.3 0.0 2.2 1 1 1 2 2 2 2 Transglycosylase SLT domain Glucosaminidase PF01832.20 ACT00199.1 - 0.00057 20.3 0.6 0.0014 19.1 0.6 1.7 1 1 0 1 1 1 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase OppC_N PF12911.7 ACT00199.1 - 0.13 12.3 0.5 1.9 8.5 0.0 2.3 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C SASP PF00269.20 ACT00200.1 - 6e-27 93.4 0.1 6.8e-27 93.3 0.1 1.0 1 0 0 1 1 1 1 Small, acid-soluble spore proteins, alpha/beta type Inhibitor_I24 PF10465.9 ACT00200.1 - 0.17 11.8 0.1 0.19 11.7 0.1 1.1 1 0 0 1 1 1 0 PinA peptidase inhibitor ATP-cone PF03477.16 ACT00201.1 - 1.7e-19 70.2 0.9 2.3e-19 69.7 0.9 1.2 1 0 0 1 1 1 1 ATP cone domain zf-C2H2_4 PF13894.6 ACT00201.1 - 0.09 13.7 2.1 8.3 7.6 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 ACT00201.1 - 0.17 11.7 0.6 0.36 10.6 0.6 1.5 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 ACT00201.1 - 0.84 10.2 4.6 9.4 6.9 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.26 ACT00201.1 - 6.1 7.5 8.0 5.6 7.6 0.2 2.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2HC_2 PF13913.6 ACT00201.1 - 8 6.5 9.2 2.5 8.1 2.8 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Glyoxalase PF00903.25 ACT00202.1 - 2.3e-10 40.8 0.0 7.8e-10 39.0 0.0 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ACT00202.1 - 0.00041 20.3 0.1 0.0026 17.7 0.1 1.9 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 ACT00202.1 - 0.0018 18.5 0.0 0.018 15.3 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DUF4926 PF16277.5 ACT00202.1 - 0.015 14.6 0.1 0.024 14.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4926) Glyoxalase_3 PF13468.6 ACT00202.1 - 0.019 15.1 0.0 0.038 14.1 0.0 1.7 1 1 0 1 1 1 0 Glyoxalase-like domain Lipase_GDSL_2 PF13472.6 ACT00203.1 - 1.9e-09 38.1 0.0 3e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family CE2_N PF17996.1 ACT00203.1 - 0.0078 16.2 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate esterase 2 N-terminal Hemocyanin_N PF03722.14 ACT00207.1 - 0.41 11.2 5.3 0.16 12.5 1.4 2.0 2 0 0 2 2 2 0 Hemocyanin, all-alpha domain Zf_RING PF16744.5 ACT00208.1 - 0.0032 17.6 0.7 0.0036 17.4 0.7 1.1 1 0 0 1 1 1 1 KIAA1045 RING finger zf-C2HC_2 PF13913.6 ACT00208.1 - 0.0041 17.0 1.4 0.006 16.4 1.4 1.3 1 0 0 1 1 1 1 zinc-finger of a C2HC-type HNH PF01844.23 ACT00210.1 - 9.5e-06 25.7 8.5 2.2e-05 24.5 8.5 1.7 1 1 0 1 1 1 1 HNH endonuclease PHD PF00628.29 ACT00210.1 - 0.0013 18.6 2.7 0.0021 17.9 2.7 1.3 1 0 0 1 1 1 1 PHD-finger zf-CCHC_3 PF13917.6 ACT00210.1 - 0.03 14.3 3.3 1.4 8.9 0.1 2.2 2 0 0 2 2 2 0 Zinc knuckle CCP_MauG PF03150.14 ACT00210.1 - 0.1 13.2 0.1 0.14 12.8 0.1 1.2 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase zf-UBR PF02207.20 ACT00210.1 - 0.4 10.9 8.0 3.9 7.7 0.4 2.1 1 1 1 2 2 2 0 Putative zinc finger in N-recognin (UBR box) zf-CCHC_2 PF13696.6 ACT00210.1 - 1.1 9.1 7.3 11 6.0 1.9 2.5 2 0 0 2 2 2 0 Zinc knuckle Med30 PF11315.8 ACT00211.1 - 0.023 14.9 2.4 0.15 12.2 2.6 1.9 1 1 0 1 1 1 0 Mediator complex subunit 30 B2 PF11473.8 ACT00211.1 - 0.083 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA binding protein B2 Terminase_1 PF03354.15 ACT00212.1 - 4.6e-67 226.6 0.0 5.9e-67 226.2 0.0 1.0 1 0 0 1 1 1 1 Phage Terminase Terminase_GpA PF05876.12 ACT00212.1 - 0.004 15.8 0.0 0.0083 14.7 0.0 1.4 2 0 0 2 2 2 1 Phage terminase large subunit (GpA) Phage_portal PF04860.12 ACT00213.1 - 3.4e-62 210.5 0.8 3.9e-62 210.3 0.8 1.0 1 0 0 1 1 1 1 Phage portal protein KTSC PF13619.6 ACT00213.1 - 0.13 12.1 0.4 0.39 10.6 0.4 1.8 1 0 0 1 1 1 0 KTSC domain DUF3574 PF12098.8 ACT00213.1 - 0.14 12.0 0.1 0.5 10.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3574) Peptidase_S78 PF04586.17 ACT00214.1 - 1.7e-33 116.1 0.4 2.3e-33 115.7 0.4 1.1 1 0 0 1 1 1 1 Caudovirus prohead serine protease Phage_capsid PF05065.13 ACT00215.1 - 6.4e-37 127.4 0.6 1e-36 126.7 0.6 1.3 1 0 0 1 1 1 1 Phage capsid family Phage_connect_1 PF05135.13 ACT00217.1 - 0.089 13.3 0.5 0.14 12.7 0.5 1.5 1 1 0 1 1 1 0 Phage gp6-like head-tail connector protein Phage_H_T_join PF05521.11 ACT00218.1 - 1.2e-05 25.7 0.0 1.4e-05 25.5 0.0 1.0 1 0 0 1 1 1 1 Phage head-tail joining protein HK97-gp10_like PF04883.12 ACT00219.1 - 1.6e-06 29.0 2.4 6.7e-06 27.0 0.2 2.2 2 0 0 2 2 2 1 Bacteriophage HK97-gp10, putative tail-component IglC PF11550.8 ACT00219.1 - 0.026 14.0 0.0 0.028 13.9 0.0 1.2 1 0 0 1 1 1 0 Intracellular growth locus C protein MRP-L27 PF09809.9 ACT00219.1 - 0.039 13.8 0.4 0.098 12.5 0.1 1.8 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L27 DUF3168 PF11367.8 ACT00220.1 - 4.3e-09 36.6 0.0 5e-09 36.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3168) Phage_TTP_12 PF16461.5 ACT00221.1 - 2.3e-15 56.5 0.1 4.6e-15 55.5 0.0 1.5 2 0 0 2 2 2 1 Lambda phage tail tube protein, TTP Phage_tail_2 PF06199.11 ACT00221.1 - 1.5e-09 38.1 0.1 5e-09 36.4 0.0 1.8 2 0 0 2 2 2 1 Phage tail tube protein Cadherin-like PF12733.7 ACT00221.1 - 1.7e-06 28.5 0.8 3.9e-06 27.3 0.8 1.6 1 0 0 1 1 1 1 Cadherin-like beta sandwich domain ComP_DUS PF16732.5 ACT00221.1 - 0.26 12.2 1.2 0.58 11.1 0.3 2.0 2 0 0 2 2 2 0 Type IV minor pilin ComP, DNA uptake sequence receptor ParD PF09386.10 ACT00222.1 - 0.006 17.0 0.7 0.15 12.5 0.7 2.1 1 1 0 1 1 1 1 Antitoxin ParD CyRPA PF18638.1 ACT00222.1 - 0.061 12.5 0.0 0.079 12.1 0.0 1.1 1 0 0 1 1 1 0 Cysteine-Rich Protective Antigen 6 bladed domain Halo_GVPC PF05465.13 ACT00222.1 - 0.087 13.1 4.3 0.16 12.2 4.3 1.5 1 0 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat TMP_2 PF06791.13 ACT00224.1 - 0.00041 20.1 7.7 0.00041 20.1 7.7 4.1 4 1 0 4 4 4 2 Prophage tail length tape measure protein Pro-kuma_activ PF09286.11 ACT00224.1 - 0.14 12.5 0.0 9.1 6.6 0.1 2.5 2 0 0 2 2 2 0 Pro-kumamolisin, activation domain COG2 PF06148.11 ACT00224.1 - 0.21 11.7 0.7 2.3 8.3 0.1 2.7 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 PRA1 PF03208.19 ACT00224.1 - 0.69 9.5 3.0 0.5 10.0 0.2 2.2 2 0 0 2 2 2 0 PRA1 family protein Vac_Fusion PF02346.16 ACT00227.1 - 0.019 14.6 0.2 0.31 10.7 0.0 2.3 1 1 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 Binary_toxB_2 PF17475.2 ACT00227.1 - 0.041 13.6 0.9 0.34 10.6 0.3 1.8 1 1 1 2 2 2 0 Clostridial binary toxin B/anthrax toxin PA domain 2 DUF5344 PF17279.2 ACT00227.1 - 0.064 13.8 0.1 0.11 13.1 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5344) LOH1CR12 PF10158.9 ACT00227.1 - 0.076 13.0 0.1 0.11 12.6 0.1 1.1 1 0 0 1 1 1 0 Tumour suppressor protein BppU_N PF10651.9 ACT00230.1 - 0.011 15.4 0.0 0.015 15.0 0.0 1.4 1 1 0 1 1 1 0 BppU N-terminal domain Invasin_D3 PF09134.10 ACT00230.1 - 0.021 15.1 0.0 0.03 14.6 0.0 1.3 1 0 0 1 1 1 0 Invasin, domain 3 DUF2501 PF10696.9 ACT00230.1 - 0.17 12.2 0.0 0.26 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2501) PDZ_2 PF13180.6 ACT00232.1 - 0.092 13.1 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 PDZ domain Phage_XkdX PF09693.10 ACT00233.1 - 4.4e-17 61.8 0.3 4.9e-17 61.7 0.3 1.1 1 0 0 1 1 1 1 Phage uncharacterised protein (Phage_XkdX) DUF2680 PF10925.8 ACT00233.1 - 0.018 15.1 0.1 0.024 14.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) NIR_SIR_ferr PF03460.17 ACT00233.1 - 0.04 13.8 0.0 0.048 13.5 0.0 1.2 1 0 0 1 1 1 0 Nitrite/Sulfite reductase ferredoxin-like half domain Phage_holin_4_1 PF05105.12 ACT00234.1 - 6.2e-31 106.9 0.2 7.7e-31 106.6 0.2 1.1 1 0 0 1 1 1 1 Bacteriophage holin family Glyco_hydro_25 PF01183.20 ACT00235.1 - 2.3e-48 164.7 0.6 3e-48 164.4 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 Cu_amine_oxidN1 PF07833.11 ACT00235.1 - 2.4e-08 34.4 0.1 5.9e-08 33.1 0.1 1.7 1 0 0 1 1 1 1 Copper amine oxidase N-terminal domain Transposon_TraM PF12508.8 ACT00236.1 - 0.043 13.5 0.2 2.3 7.8 0.1 2.1 2 0 0 2 2 2 0 Conjugative transposon, TraM FAM70 PF14967.6 ACT00236.1 - 0.19 11.2 0.3 0.22 11.0 0.3 1.1 1 0 0 1 1 1 0 FAM70 protein LacI PF00356.21 ACT00237.1 - 0.12 12.1 0.1 0.16 11.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family ALP_N PF17989.1 ACT00238.1 - 8.4e-15 55.2 0.0 1.2e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 Actin like proteins N terminal domain TrwB_AAD_bind PF10412.9 ACT00242.1 - 3.5e-05 22.9 0.0 0.15 10.9 0.0 2.3 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain RsgA_GTPase PF03193.16 ACT00242.1 - 0.0016 18.4 1.0 0.031 14.2 0.0 3.1 4 0 0 4 4 4 1 RsgA GTPase AAA_29 PF13555.6 ACT00242.1 - 0.038 13.7 0.1 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_18 PF13238.6 ACT00242.1 - 0.043 14.4 0.0 1.5 9.4 0.0 3.1 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ACT00242.1 - 0.055 14.0 0.0 0.15 12.6 0.0 1.8 1 0 0 1 1 1 0 ABC transporter CLP1_P PF16575.5 ACT00242.1 - 0.086 12.6 0.0 0.29 10.9 0.0 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 ACT00242.1 - 0.092 13.1 0.0 0.32 11.4 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain Pex24p PF06398.11 ACT00243.1 - 0.25 10.3 9.9 0.22 10.5 0.4 2.2 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin AgrB PF04647.15 ACT00244.1 - 1.8e-18 66.5 7.0 2.3e-18 66.1 7.0 1.1 1 0 0 1 1 1 1 Accessory gene regulator B DUF4094 PF13334.6 ACT00244.1 - 0.14 12.6 1.2 0.57 10.6 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) Tmemb_18A PF09771.9 ACT00244.1 - 5.6 7.4 6.9 5 7.6 1.5 2.6 1 1 2 3 3 3 0 Transmembrane protein 188 LytTR PF04397.15 ACT00246.1 - 0.0018 18.4 0.0 0.0024 18.1 0.0 1.3 1 0 0 1 1 1 1 LytTr DNA-binding domain HTH_31 PF13560.6 ACT00247.1 - 8.4e-07 29.2 0.0 1.4e-06 28.5 0.0 1.4 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 ACT00247.1 - 1.6e-06 28.1 0.1 2.1e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain Pou PF00157.17 ACT00247.1 - 1e-05 25.4 0.0 1.1e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain HTH_3 PF01381.22 ACT00247.1 - 2.8e-05 24.1 0.0 0.00011 22.1 0.0 1.9 1 1 0 1 1 1 1 Helix-turn-helix HTH_25 PF13413.6 ACT00247.1 - 0.072 13.0 0.2 0.11 12.3 0.2 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain Peptidase_S24 PF00717.23 ACT00248.1 - 0.037 14.0 0.1 0.31 11.0 0.1 2.0 1 1 0 1 1 1 0 Peptidase S24-like PBP5_C PF07943.13 ACT00248.1 - 0.058 13.6 0.2 0.073 13.3 0.2 1.3 1 0 0 1 1 1 0 Penicillin-binding protein 5, C-terminal domain HTH_3 PF01381.22 ACT00249.1 - 3.8e-14 52.5 0.5 6.9e-14 51.6 0.5 1.5 1 0 0 1 1 1 1 Helix-turn-helix Peptidase_S24 PF00717.23 ACT00249.1 - 6.7e-12 45.2 0.0 1.1e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like HTH_31 PF13560.6 ACT00249.1 - 6.4e-09 36.0 0.1 1.1e-08 35.2 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 ACT00249.1 - 1.5e-08 34.5 0.5 3.4e-08 33.4 0.4 1.7 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 ACT00249.1 - 9.3e-07 29.2 0.1 1.5e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain YdaS_antitoxin PF15943.5 ACT00249.1 - 0.033 14.1 0.1 0.095 12.6 0.1 1.8 1 1 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT MerR PF00376.23 ACT00249.1 - 0.059 13.2 0.1 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 MerR family regulatory protein HTH_19 PF12844.7 ACT00250.1 - 1.9e-09 37.4 0.0 2.3e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 ACT00250.1 - 8.9e-08 32.1 0.0 1e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ACT00250.1 - 3.2e-06 27.4 0.0 3.9e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain BetR PF08667.10 ACT00250.1 - 3.1e-05 24.1 0.0 3.3e-05 23.9 0.0 1.0 1 0 0 1 1 1 1 BetR domain DUF739 PF05339.11 ACT00250.1 - 0.014 15.5 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF739) HTH_26 PF13443.6 ACT00250.1 - 0.028 14.9 0.0 0.029 14.8 0.0 1.1 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain HTH_10 PF04967.12 ACT00250.1 - 0.097 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain MqsA_antitoxin PF15731.5 ACT00250.1 - 0.13 12.4 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_23 PF13384.6 ACT00250.1 - 0.13 12.1 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain ATP-synt_ab PF00006.25 ACT00250.1 - 0.15 11.7 0.1 0.16 11.6 0.1 1.0 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Phage_pRha PF09669.10 ACT00251.1 - 6.3e-30 103.6 0.6 2.5e-29 101.6 0.0 2.2 3 0 0 3 3 3 1 Phage regulatory protein Rha (Phage_pRha) ORF6C PF10552.9 ACT00251.1 - 2.7e-16 59.7 0.3 4.5e-16 59.0 0.3 1.3 1 0 0 1 1 1 1 ORF6C domain ApoC-I PF04691.12 ACT00254.1 - 0.021 14.7 0.6 0.12 12.3 0.1 2.4 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) DUF45 PF01863.17 ACT00254.1 - 0.065 13.3 1.2 0.45 10.5 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function DUF45 CelTOS PF18659.1 ACT00254.1 - 0.47 10.9 3.8 10 6.6 0.7 2.4 2 1 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites AAA_23 PF13476.6 ACT00255.1 - 1.8e-05 25.4 5.8 1.8e-05 25.4 5.8 2.7 1 1 1 2 2 2 1 AAA domain MscS_porin PF12795.7 ACT00255.1 - 0.0018 17.9 6.1 0.0018 17.9 6.1 2.9 2 1 1 3 3 3 2 Mechanosensitive ion channel porin domain AAA_15 PF13175.6 ACT00255.1 - 0.0036 17.1 5.0 0.0036 17.1 5.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT00255.1 - 0.0042 16.8 0.1 0.011 15.5 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain MukB PF04310.12 ACT00255.1 - 0.063 13.1 0.8 0.56 10.0 0.1 2.4 2 0 0 2 2 2 0 MukB N-terminal kleA_kleC PF17383.2 ACT00255.1 - 2.7 8.4 9.0 2.5 8.5 0.7 3.8 3 1 0 3 3 3 0 Uncharacterized KorC regulated protein A RecT PF03837.14 ACT00257.1 - 3e-34 118.2 0.0 4.6e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 RecT family DUF3597 PF12200.8 ACT00257.1 - 0.096 13.2 1.2 0.2 12.2 1.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3597) HNH_3 PF13392.6 ACT00258.1 - 6.4e-09 35.4 3.6 1.5e-08 34.3 3.6 1.6 1 0 0 1 1 1 1 HNH endonuclease AP2 PF00847.20 ACT00258.1 - 3.5e-06 27.1 0.4 3.5e-06 27.1 0.4 2.0 2 0 0 2 2 2 1 AP2 domain Lactamase_B_2 PF12706.7 ACT00259.1 - 1.8e-15 57.0 0.7 2.8e-15 56.4 0.7 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACT00259.1 - 2.3e-07 31.0 0.8 8.3e-07 29.2 0.2 2.1 1 1 1 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.6 ACT00259.1 - 0.025 14.5 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain DUF1642 PF07852.11 ACT00260.1 - 9.9e-07 29.4 0.0 1.7e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1642) CENP-F_leu_zip PF10473.9 ACT00260.1 - 0.0024 17.9 2.4 0.0043 17.1 2.4 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SAS4 PF15460.6 ACT00260.1 - 0.035 14.2 1.6 2.2 8.4 0.4 2.4 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 Phage_rep_O PF04492.13 ACT00261.1 - 1.3e-29 102.6 0.5 2.4e-29 101.8 0.5 1.4 1 0 0 1 1 1 1 Bacteriophage replication protein O Cullin PF00888.22 ACT00261.1 - 0.014 14.0 0.1 0.02 13.5 0.1 1.2 1 0 0 1 1 1 0 Cullin family DnaB_C PF03796.15 ACT00262.1 - 6e-114 379.7 1.1 7.8e-114 379.3 1.1 1.1 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain DnaB PF00772.21 ACT00262.1 - 9.2e-29 99.6 0.0 2.4e-28 98.2 0.0 1.8 1 0 0 1 1 1 1 DnaB-like helicase N terminal domain AAA_25 PF13481.6 ACT00262.1 - 8.8e-09 35.2 0.0 1.5e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ACT00262.1 - 7.1e-05 22.3 1.0 0.00026 20.4 1.0 1.9 1 1 0 1 1 1 1 KaiC AAA PF00004.29 ACT00262.1 - 9.3e-05 22.9 0.9 0.00073 20.0 0.3 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ACT00262.1 - 0.0072 16.1 0.2 0.04 13.7 0.2 2.0 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ACT00262.1 - 0.056 13.2 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain IDEAL PF08858.10 ACT00263.1 - 0.0046 16.7 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 IDEAL domain LexA_DNA_bind PF01726.16 ACT00264.1 - 2.9e-18 65.4 0.1 4e-18 65.0 0.1 1.2 1 0 0 1 1 1 1 LexA DNA binding domain MarR_2 PF12802.7 ACT00264.1 - 0.00013 21.8 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 MarR family Penicillinase_R PF03965.16 ACT00264.1 - 0.00042 20.7 0.0 0.00055 20.3 0.0 1.3 1 1 0 1 1 1 1 Penicillinase repressor HTH_24 PF13412.6 ACT00264.1 - 0.024 14.2 0.0 0.051 13.1 0.0 1.7 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding CobN-Mg_chel PF02514.16 ACT00264.1 - 0.025 12.4 0.0 0.026 12.3 0.0 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase HTH_IclR PF09339.10 ACT00264.1 - 0.058 13.2 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain NETI PF14044.6 ACT00264.1 - 0.14 11.9 0.0 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 NETI protein DUF460 PF04312.13 ACT00265.1 - 0.12 12.0 0.4 0.27 10.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF460) IZUMO PF15005.6 ACT00266.1 - 0.085 13.4 0.1 0.11 13.0 0.1 1.3 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated HNH_3 PF13392.6 ACT00267.1 - 2.5e-15 56.0 0.4 2.5e-15 56.0 0.4 1.6 2 0 0 2 2 2 1 HNH endonuclease dUTPase_2 PF08761.11 ACT00268.1 - 1.1e-36 126.6 0.0 1.2e-36 126.4 0.0 1.0 1 0 0 1 1 1 1 dUTPase DNA_methylase PF00145.17 ACT00269.1 - 7.8e-28 97.8 0.0 9.3e-20 71.2 0.0 2.2 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase N6_N4_Mtase PF01555.18 ACT00271.1 - 1.8e-47 162.0 0.0 2.2e-47 161.7 0.0 1.1 1 0 0 1 1 1 1 DNA methylase HTH_24 PF13412.6 ACT00272.1 - 3e-05 23.5 0.1 0.016 14.7 0.1 2.8 3 0 0 3 3 3 2 Winged helix-turn-helix DNA-binding MarR PF01047.22 ACT00272.1 - 0.024 14.6 0.2 1.3 9.0 0.0 2.2 2 0 0 2 2 2 0 MarR family Zn-ribbon_8 PF09723.10 ACT00274.1 - 0.088 12.9 0.9 0.088 12.9 0.9 2.1 1 1 1 2 2 2 0 Zinc ribbon domain Sigma70_r4_2 PF08281.12 ACT00275.1 - 2.4e-12 46.3 0.4 4e-12 45.6 0.4 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT00275.1 - 1e-08 34.6 0.2 5.5e-08 32.2 0.0 2.1 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_29 PF13551.6 ACT00275.1 - 0.0037 17.2 0.1 0.013 15.5 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn helix GerE PF00196.19 ACT00275.1 - 0.0052 16.3 0.7 0.015 14.8 0.1 2.0 1 1 1 2 2 2 1 Bacterial regulatory proteins, luxR family HTH_10 PF04967.12 ACT00275.1 - 0.046 13.5 4.5 0.23 11.3 0.1 2.9 3 0 0 3 3 3 0 HTH DNA binding domain HTH_24 PF13412.6 ACT00275.1 - 0.061 12.9 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_36 PF13730.6 ACT00275.1 - 0.065 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Rtt106 PF08512.12 ACT00276.1 - 0.036 14.5 0.1 0.047 14.1 0.1 1.2 1 0 0 1 1 1 0 Histone chaperone Rttp106-like Phage_XkdX PF09693.10 ACT00276.1 - 0.046 13.7 2.0 0.35 10.9 0.6 2.4 2 1 0 2 2 2 0 Phage uncharacterised protein (Phage_XkdX) Resolvase PF00239.21 ACT00277.1 - 1.7e-17 63.9 0.1 4.9e-17 62.4 0.0 1.8 2 0 0 2 2 2 1 Resolvase, N terminal domain Recombinase PF07508.13 ACT00277.1 - 2.1e-13 50.5 0.0 6.3e-13 49.0 0.0 1.9 1 0 0 1 1 1 1 Recombinase Zn_ribbon_recom PF13408.6 ACT00277.1 - 3.1e-12 46.8 0.8 6.3e-12 45.8 0.8 1.5 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain CCDC-167 PF15188.6 ACT00277.1 - 2.4 8.6 5.9 0.75 10.2 0.4 2.6 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 HupE_UreJ_2 PF13795.6 ACT00278.1 - 2.6e-47 160.3 9.3 3.9e-47 159.8 9.3 1.2 1 0 0 1 1 1 1 HupE / UreJ protein HupE_UreJ PF04955.12 ACT00278.1 - 3e-09 36.6 9.1 4.6e-09 36.0 9.1 1.3 1 0 0 1 1 1 1 HupE / UreJ protein WG_beta_rep PF14903.6 ACT00279.1 - 2.1e-54 181.4 29.7 9.5e-12 45.0 0.0 10.3 8 3 2 10 10 10 9 WG containing repeat DsbC_N PF10411.9 ACT00279.1 - 5.8 6.4 6.4 19 4.8 0.0 4.1 5 0 0 5 5 5 0 Disulfide bond isomerase protein N-terminus SLH PF00395.20 ACT00280.1 - 7.6e-30 102.7 4.6 2.2e-11 43.6 0.3 3.9 3 0 0 3 3 3 3 S-layer homology domain Big_3 PF07523.12 ACT00280.1 - 2.7e-17 62.8 4.7 2.7e-17 62.8 4.7 5.0 5 0 0 5 5 5 1 Bacterial Ig-like domain (group 3) Fn3_assoc PF13287.6 ACT00280.1 - 1.9e-07 31.1 0.6 1.9e-07 31.1 0.6 4.6 4 0 0 4 4 4 2 Fn3 associated CHB_HEX_C_1 PF13290.6 ACT00280.1 - 6e-06 26.2 2.6 6e-06 26.2 2.6 7.1 7 0 0 7 7 7 3 Chitobiase/beta-hexosaminidase C-terminal domain tRNA_anti-codon PF01336.25 ACT00280.1 - 0.00094 19.1 0.3 2.2 8.3 0.0 4.9 5 0 0 5 5 5 1 OB-fold nucleic acid binding domain BNR_2 PF13088.6 ACT00281.1 - 5e-18 65.4 0.3 9.3e-11 41.5 0.0 2.7 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.20 ACT00281.1 - 6.2e-08 31.5 9.3 0.8 10.0 0.1 5.9 5 0 0 5 5 5 3 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 ACT00281.1 - 0.00012 21.1 2.6 0.0089 14.9 1.3 3.0 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR_3 PF13859.6 ACT00281.1 - 0.00096 18.5 3.7 0.02 14.2 0.3 2.4 2 1 0 2 2 2 2 BNR repeat-like domain BNR_4 PF15892.5 ACT00281.1 - 0.0013 18.2 0.6 0.034 13.5 0.1 2.6 1 1 0 2 2 2 1 BNR repeat-containing family member CyRPA PF18638.1 ACT00281.1 - 0.0091 15.2 0.2 6.3 5.8 0.0 3.3 3 0 0 3 3 3 1 Cysteine-Rich Protective Antigen 6 bladed domain DUF4185 PF13810.6 ACT00281.1 - 0.039 13.2 6.1 9.4 5.4 0.1 4.0 2 1 1 4 4 4 0 Domain of unknown function (DUF4185) DUF3673 PF12425.8 ACT00281.1 - 0.082 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3673) LPAM_1 PF08139.12 ACT00281.1 - 1 10.0 4.3 2.5 8.7 4.3 1.7 1 1 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site GntR PF00392.21 ACT00282.1 - 5.3e-18 64.4 0.0 1.3e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Peripla_BP_3 PF13377.6 ACT00282.1 - 4.2e-15 56.5 0.0 7.1e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT00282.1 - 2.5e-06 27.2 0.0 3.8e-06 26.5 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT00282.1 - 0.098 12.2 0.0 0.24 10.9 0.0 1.8 1 1 0 1 1 1 0 Periplasmic binding protein domain Glyco_hydro_2_N PF02837.18 ACT00283.1 - 8.8e-23 81.0 1.1 2.9e-22 79.4 1.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 ACT00283.1 - 1.2e-14 54.1 0.5 1.1e-12 47.8 0.5 2.9 2 1 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ACT00283.1 - 4.3e-10 40.2 0.0 8.3e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 ACT00283.1 - 0.0023 18.5 0.0 0.0051 17.4 0.0 1.6 1 0 0 1 1 1 1 Beta-galactosidase jelly roll domain ArsA_HSP20 PF17886.1 ACT00283.1 - 0.014 15.0 0.0 0.03 13.9 0.0 1.5 1 0 0 1 1 1 0 HSP20-like domain found in ArsA Cellulase PF00150.18 ACT00283.1 - 0.054 12.9 0.4 0.1 12.0 0.4 1.4 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) SBP_bac_8 PF13416.6 ACT00284.1 - 5.4e-48 164.2 16.4 8e-48 163.7 16.4 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT00284.1 - 2.3e-34 119.8 16.7 3.4e-34 119.2 16.7 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT00285.1 - 3.1e-20 72.7 20.3 3.1e-20 72.7 20.3 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00286.1 - 2.5e-17 63.2 11.1 2.5e-17 63.2 11.1 2.1 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BNR_2 PF13088.6 ACT00287.1 - 1.4e-13 50.8 0.2 6.8e-09 35.4 0.0 2.5 1 1 1 2 2 2 2 BNR repeat-like domain Cellulase PF00150.18 ACT00287.1 - 1.1e-06 28.3 1.4 5.5e-06 26.0 0.4 2.5 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Sortilin-Vps10 PF15902.5 ACT00287.1 - 0.00032 19.6 0.3 0.066 12.0 0.0 2.6 3 0 0 3 3 3 2 Sortilin, neurotensin receptor 3, BNR PF02012.20 ACT00287.1 - 0.00036 20.1 16.9 6.3 7.2 0.1 6.6 6 0 0 6 6 6 4 BNR/Asp-box repeat DUF1080 PF06439.11 ACT00288.1 - 8.3e-15 55.4 6.9 2e-08 34.6 1.8 2.6 2 0 0 2 2 2 2 Domain of Unknown Function (DUF1080) BNR_2 PF13088.6 ACT00288.1 - 9.9e-10 38.2 2.0 5.9e-07 29.1 0.2 2.5 1 1 1 2 2 2 2 BNR repeat-like domain Alginate_lyase2 PF08787.11 ACT00288.1 - 0.015 15.1 0.9 1.5 8.6 0.3 2.4 1 1 1 2 2 2 0 Alginate lyase Bac_luciferase PF00296.20 ACT00289.1 - 8.1e-53 179.9 0.0 1.1e-52 179.4 0.0 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase ABC_tran PF00005.27 ACT00290.1 - 5.5e-35 120.9 0.0 8.2e-35 120.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00290.1 - 5.1e-08 33.1 0.5 0.0005 20.0 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT00290.1 - 0.00019 20.9 0.6 0.0013 18.2 0.6 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT00290.1 - 0.0008 19.7 0.6 0.0057 16.9 0.6 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT00290.1 - 0.00096 19.6 0.0 0.0022 18.4 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ACT00290.1 - 0.011 15.6 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 ACT00290.1 - 0.011 15.4 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 ACT00290.1 - 0.072 12.5 0.1 0.91 8.9 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_33 PF13671.6 ACT00290.1 - 0.084 13.0 0.1 0.18 12.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACT00290.1 - 0.12 12.5 0.0 0.34 11.0 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase Adeno_IVa2 PF02456.15 ACT00290.1 - 0.19 10.5 0.0 0.32 9.8 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_23 PF13476.6 ACT00290.1 - 0.2 12.1 0.3 0.43 11.0 0.1 1.6 2 0 0 2 2 2 0 AAA domain BPD_transp_1 PF00528.22 ACT00291.1 - 3.8e-15 56.1 19.6 3.8e-15 56.1 19.6 1.6 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Lipoprotein_9 PF03180.14 ACT00292.1 - 1.9e-85 285.7 2.4 2.2e-85 285.5 2.4 1.0 1 0 0 1 1 1 1 NLPA lipoprotein DUF4969 PF16339.5 ACT00292.1 - 1.4e-05 25.3 0.0 3.8e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4969) CAAX_1 PF15895.5 ACT00292.1 - 0.015 15.2 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 CAAX box cerebral protein 1 Phosphonate-bd PF12974.7 ACT00292.1 - 0.036 13.6 0.0 0.18 11.4 0.0 2.0 2 0 0 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein DUF3558 PF12079.8 ACT00292.1 - 0.65 10.0 3.8 1 9.3 3.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) AraC_binding PF02311.19 ACT00293.1 - 2.1e-22 79.5 0.0 3.4e-22 78.8 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_18 PF12833.7 ACT00293.1 - 8.9e-19 67.5 0.0 1.4e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00293.1 - 4.8e-14 52.0 0.0 5.4e-08 32.7 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding_2 PF14525.6 ACT00293.1 - 0.00029 20.5 0.0 0.00057 19.6 0.0 1.4 1 0 0 1 1 1 1 AraC-binding-like domain HTH_7 PF02796.15 ACT00293.1 - 0.018 15.1 0.0 0.052 13.6 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Cupin_2 PF07883.11 ACT00293.1 - 0.065 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Cupin domain MarR_2 PF12802.7 ACT00293.1 - 0.1 12.5 0.0 0.35 10.8 0.0 1.9 2 0 0 2 2 2 0 MarR family AbiEi_4 PF13338.6 ACT00293.1 - 0.17 12.1 0.0 0.8 9.9 0.0 2.0 1 1 1 2 2 2 0 Transcriptional regulator, AbiEi antitoxin Aldo_ket_red PF00248.21 ACT00294.1 - 1.3e-67 228.1 0.0 1.5e-67 227.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Resolvase PF00239.21 ACT00295.1 - 0.00044 20.4 0.2 0.0013 18.9 0.2 1.8 1 1 0 1 1 1 1 Resolvase, N terminal domain ABC_sub_bind PF04392.12 ACT00295.1 - 0.057 12.6 0.1 0.06 12.6 0.1 1.1 1 0 0 1 1 1 0 ABC transporter substrate binding protein Cu_amine_oxidN1 PF07833.11 ACT00296.1 - 7.9e-22 77.6 0.4 2.8e-14 53.3 0.0 2.4 1 1 1 2 2 2 2 Copper amine oxidase N-terminal domain Methyltransf_31 PF13847.6 ACT00298.1 - 1e-08 35.2 0.1 2.3e-08 33.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT00298.1 - 5.1e-07 30.3 0.0 1.1e-06 29.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT00298.1 - 6.5e-05 23.5 0.0 0.00016 22.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT00298.1 - 0.00097 19.0 0.0 0.0045 16.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ACT00298.1 - 0.054 13.1 0.0 0.091 12.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 ACT00298.1 - 0.084 12.9 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 ACT00298.1 - 0.093 13.5 0.0 0.21 12.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain CobT_C PF11775.8 ACT00298.1 - 0.11 12.2 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT VWA domain ABC_tran PF00005.27 ACT00299.1 - 3.6e-34 118.2 0.0 7e-34 117.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter CBS PF00571.28 ACT00299.1 - 7.5e-17 61.5 1.2 4.8e-07 30.1 0.1 2.7 2 0 0 2 2 2 2 CBS domain AAA_21 PF13304.6 ACT00299.1 - 3.2e-11 43.6 0.6 1.8e-05 24.7 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ACT00299.1 - 3.7e-06 26.9 0.0 6.7e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ACT00299.1 - 7.7e-05 22.7 0.0 0.00021 21.2 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 ACT00299.1 - 8.2e-05 22.1 0.2 0.23 10.9 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 ACT00299.1 - 0.00019 20.4 0.3 0.046 12.5 0.0 2.4 2 0 0 2 2 2 1 Predicted ATPase of the ABC class Rad17 PF03215.15 ACT00299.1 - 0.0002 21.3 0.0 0.00037 20.5 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 ACT00299.1 - 0.00023 21.6 0.2 0.0013 19.1 0.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT00299.1 - 0.00037 20.2 0.0 0.00073 19.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ACT00299.1 - 0.00059 20.1 0.1 0.0024 18.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ACT00299.1 - 0.00072 19.5 0.2 0.0016 18.4 0.0 1.6 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 ACT00299.1 - 0.0011 19.3 0.0 0.0028 18.0 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_23 PF13476.6 ACT00299.1 - 0.0023 18.5 0.4 0.0023 18.5 0.4 2.0 2 1 0 2 2 1 1 AAA domain AAA PF00004.29 ACT00299.1 - 0.0049 17.3 0.2 0.041 14.3 0.2 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ACT00299.1 - 0.0054 16.5 0.0 0.015 15.1 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ACT00299.1 - 0.0073 16.5 0.0 0.027 14.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ACT00299.1 - 0.0075 16.3 0.0 0.029 14.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ACT00299.1 - 0.0098 15.9 0.0 0.096 12.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ACT00299.1 - 0.012 15.2 0.1 0.044 13.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ACT00299.1 - 0.017 15.6 0.0 0.058 13.9 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.6 ACT00299.1 - 0.018 14.8 0.2 0.44 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ACT00299.1 - 0.023 14.6 0.0 0.062 13.2 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 ACT00299.1 - 0.04 14.2 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ACT00299.1 - 0.046 14.0 0.2 0.71 10.2 0.2 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 ACT00299.1 - 0.079 12.1 0.0 0.095 11.8 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit TniB PF05621.11 ACT00299.1 - 0.082 12.3 0.2 2.5 7.5 0.0 2.7 3 0 0 3 3 3 0 Bacterial TniB protein NB-ARC PF00931.22 ACT00299.1 - 0.13 11.4 0.0 0.24 10.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.19 ACT00299.1 - 0.16 11.5 0.1 0.38 10.3 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PFK PF00365.20 ACT00299.1 - 0.16 11.2 0.0 13 5.1 0.0 2.1 2 0 0 2 2 2 0 Phosphofructokinase AAA_7 PF12775.7 ACT00299.1 - 0.18 11.3 0.0 0.36 10.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP-synt_ab PF00006.25 ACT00299.1 - 0.19 11.3 0.0 0.22 11.1 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MMR_HSR1 PF01926.23 ACT00299.1 - 0.2 11.7 0.3 2.4 8.2 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase BPD_transp_1 PF00528.22 ACT00300.1 - 6.8e-24 84.6 17.4 8.7e-24 84.3 17.4 1.1 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component OpuAC PF04069.12 ACT00301.1 - 6.9e-52 176.6 1.4 7.8e-52 176.4 1.4 1.0 1 0 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system LPAM_2 PF13627.6 ACT00301.1 - 0.77 9.7 3.2 1.3 8.9 3.2 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site BPD_transp_1 PF00528.22 ACT00302.1 - 2.5e-22 79.5 14.4 2.5e-22 79.5 14.4 1.3 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Oxidored_q2 PF00420.24 ACT00302.1 - 0.14 11.8 15.8 0.04 13.5 10.2 2.1 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L APH PF01636.23 ACT00303.1 - 3e-14 53.5 0.2 6.1e-14 52.5 0.2 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Acetyltransf_1 PF00583.25 ACT00303.1 - 4.5e-10 39.8 0.0 9.3e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family EcKinase PF02958.20 ACT00303.1 - 1e-07 31.6 0.1 1.6e-07 31.0 0.1 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 ACT00303.1 - 1.3e-06 28.2 0.2 2.4e-06 27.3 0.2 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 ACT00303.1 - 1.8e-06 27.1 0.1 1.6e-05 24.0 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) Acetyltransf_7 PF13508.7 ACT00303.1 - 8e-06 26.2 0.0 1.7e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT00303.1 - 3e-05 23.9 0.0 5.8e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT00303.1 - 0.0069 16.3 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein adh_short PF00106.25 ACT00304.1 - 8.6e-24 84.1 0.0 7.2e-17 61.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ACT00304.1 - 1.4e-13 51.0 0.0 2.6e-12 46.8 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ACT00304.1 - 6.2e-07 29.1 0.0 8.3e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ACT00304.1 - 2.7e-05 24.2 0.0 5.3e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 ACT00304.1 - 0.00044 19.4 0.0 0.00067 18.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ACT00304.1 - 0.024 14.5 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ACT00304.1 - 0.043 13.2 0.0 0.062 12.7 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase MerR_1 PF13411.6 ACT00305.1 - 7.1e-16 58.1 0.1 1.4e-15 57.2 0.1 1.4 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT00305.1 - 1.7e-13 50.1 0.1 1.7e-13 50.1 0.1 1.6 2 0 0 2 2 2 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT00305.1 - 6.9e-06 26.5 0.0 1.1e-05 25.8 0.0 1.3 1 0 0 1 1 1 1 MerR, DNA binding DUF892 PF05974.12 ACT00305.1 - 0.013 15.6 0.0 0.018 15.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF892) DUF1836 PF08876.11 ACT00305.1 - 0.025 14.6 0.1 0.13 12.3 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1836) HTH_17 PF12728.7 ACT00305.1 - 0.042 14.0 0.0 0.079 13.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_ner PF04546.13 ACT00305.1 - 0.061 13.2 0.1 0.094 12.6 0.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Sigma70_r4_2 PF08281.12 ACT00305.1 - 0.12 12.1 0.2 0.4 10.4 0.0 2.0 2 1 0 2 2 2 0 Sigma-70, region 4 HTH_3 PF01381.22 ACT00305.1 - 0.14 12.2 0.1 0.35 11.0 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix ABC_tran PF00005.27 ACT00306.1 - 2.1e-31 109.3 0.0 3.8e-31 108.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00306.1 - 2.3e-09 37.5 0.3 0.0018 18.2 0.0 2.5 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT00306.1 - 7.6e-07 28.8 0.0 0.00089 18.8 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ACT00306.1 - 0.0013 18.8 0.0 0.011 15.8 0.0 2.6 3 1 1 4 4 4 1 50S ribosome-binding GTPase AAA_23 PF13476.6 ACT00306.1 - 0.0014 19.2 0.1 0.0027 18.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain LapA_dom PF06305.11 ACT00306.1 - 0.006 16.4 3.9 0.015 15.1 0.6 2.6 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain DUF3584 PF12128.8 ACT00306.1 - 0.007 13.9 0.0 0.01 13.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_29 PF13555.6 ACT00306.1 - 0.0097 15.6 0.0 0.031 14.0 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain SRP54 PF00448.22 ACT00306.1 - 0.018 14.7 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_membrane PF00664.23 ACT00306.1 - 0.021 14.5 3.7 0.021 14.5 0.6 2.3 2 1 0 2 2 2 0 ABC transporter transmembrane region AAA_28 PF13521.6 ACT00306.1 - 0.036 14.3 0.6 0.088 13.0 0.6 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACT00306.1 - 0.043 13.7 0.0 0.096 12.6 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 ACT00306.1 - 0.18 11.5 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 ACT00306.1 - 0.19 11.4 0.2 0.42 10.3 0.2 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ACT00307.1 - 4.5e-28 98.5 0.0 8.2e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT00307.1 - 8.9e-06 25.3 0.1 0.03 13.8 0.0 2.3 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT00307.1 - 0.00016 21.6 0.0 0.5 10.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ACT00307.1 - 0.022 15.1 0.0 0.047 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.22 ACT00307.1 - 0.03 14.0 0.0 0.061 12.9 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 ACT00307.1 - 0.045 13.0 0.0 0.098 11.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_15 PF13175.6 ACT00307.1 - 0.076 12.7 0.1 0.39 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 ACT00307.1 - 0.077 13.2 0.0 0.42 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ACT00307.1 - 0.085 12.6 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 ACT00307.1 - 0.11 12.5 0.2 0.6 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC_membrane PF00664.23 ACT00307.1 - 0.75 9.4 7.5 0.19 11.4 1.5 2.2 2 0 0 2 2 2 0 ABC transporter transmembrane region Vut_1 PF02592.15 ACT00307.1 - 1.8 8.9 7.4 6.9 7.0 7.4 2.0 1 1 0 1 1 1 0 Putative vitamin uptake transporter MFS_1 PF07690.16 ACT00310.1 - 2.1e-33 115.7 56.4 1.5e-19 70.1 28.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ACT00310.1 - 1.3 8.3 35.6 4.3 6.5 35.6 1.8 1 1 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB TetR_N PF00440.23 ACT00311.1 - 6.2e-13 48.3 0.1 1.4e-12 47.1 0.1 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_11 PF16859.5 ACT00311.1 - 0.0073 16.6 0.0 0.016 15.6 0.0 1.7 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain HAD_2 PF13419.6 ACT00311.1 - 0.089 12.9 0.1 0.16 12.0 0.1 1.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF347 PF03988.12 ACT00312.1 - 4 7.7 6.7 0.91 9.8 2.9 1.7 1 1 1 2 2 2 0 Repeat of Unknown Function (DUF347) Spa1_C PF18218.1 ACT00313.1 - 0.0026 18.2 0.3 0.24 11.8 0.0 2.1 1 1 1 2 2 2 2 Lantibiotic immunity protein Spa1 C-terminal domain LPD29 PF18847.1 ACT00314.1 - 1.7e-05 25.6 0.2 4e-05 24.4 0.2 1.7 1 1 0 1 1 1 1 Large polyvalent protein associated domain 29 Phage_CRI PF05144.14 ACT00314.1 - 0.023 14.0 0.3 0.027 13.8 0.3 1.1 1 0 0 1 1 1 0 Phage replication protein CRI DUF4306 PF14154.6 ACT00314.1 - 0.13 12.4 1.5 0.98 9.6 0.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4306) YjcZ_2 PF09680.10 ACT00315.1 - 0.026 14.2 12.2 0.078 12.6 12.2 1.9 1 0 0 1 1 1 0 Family of unknown function CRISPR_Cas2 PF09827.9 ACT00316.1 - 0.02 15.1 0.1 0.028 14.6 0.1 1.2 1 0 0 1 1 1 0 CRISPR associated protein Cas2 Spore_GerAC PF05504.11 ACT00317.1 - 5e-31 108.1 2.1 6.9e-31 107.7 0.6 1.9 2 0 0 2 2 2 1 Spore germination B3/ GerAC like, C-terminal GMC_oxred_N PF00732.19 ACT00319.1 - 5e-50 170.6 0.0 6.4e-50 170.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ACT00319.1 - 8.1e-25 88.0 0.0 1.3e-24 87.3 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ACT00319.1 - 6.9e-05 22.1 0.1 0.16 11.0 0.0 2.4 3 0 0 3 3 3 2 FAD binding domain Pyr_redox_2 PF07992.14 ACT00319.1 - 0.00044 19.6 0.0 0.0048 16.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ACT00319.1 - 0.00062 20.0 0.1 0.0015 18.7 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ACT00319.1 - 0.0073 15.6 0.0 0.088 12.1 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT00319.1 - 0.022 14.4 0.1 5.1 6.6 0.1 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ACT00319.1 - 0.035 13.2 0.0 0.053 12.6 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.14 ACT00319.1 - 0.15 10.8 0.0 0.27 9.9 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein DUF2975 PF11188.8 ACT00320.1 - 1.7e-37 128.2 1.8 1.7e-37 128.2 1.8 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2975) Beta-lactamase PF00144.24 ACT00321.1 - 2.3e-63 214.5 1.2 3e-63 214.1 1.2 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF4432 PF14486.6 ACT00322.1 - 1.6e-25 89.5 0.0 5.1e-23 81.3 0.0 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4432) Peripla_BP_3 PF13377.6 ACT00323.1 - 1.2e-36 126.5 0.0 3.3e-36 125.1 0.0 1.7 2 0 0 2 2 2 1 Periplasmic binding protein-like domain LacI PF00356.21 ACT00323.1 - 2.2e-20 72.2 0.2 4.5e-20 71.2 0.2 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_1 PF00532.21 ACT00323.1 - 7.3e-20 71.5 0.0 1.2e-19 70.8 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT00323.1 - 5.2e-15 55.7 0.0 2e-12 47.2 0.0 2.0 1 1 1 2 2 2 2 Periplasmic binding protein domain HTH_3 PF01381.22 ACT00323.1 - 0.0075 16.3 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix Diphthamide_syn PF01866.17 ACT00323.1 - 0.015 14.8 0.6 0.046 13.2 0.6 1.6 1 1 0 1 1 1 0 Putative diphthamide synthesis protein HTH_7 PF02796.15 ACT00323.1 - 0.068 13.3 0.2 2.9 8.1 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase Tox-HDC PF15656.6 ACT00323.1 - 0.28 11.4 5.5 5.7 7.1 0.2 3.1 2 1 1 3 3 3 0 Toxin with a H, D/N and C signature HTH_18 PF12833.7 ACT00325.1 - 4.1e-19 68.6 0.0 9e-19 67.5 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00325.1 - 3.5e-14 52.4 0.0 3.9e-09 36.4 0.0 2.9 2 1 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT00325.1 - 3e-05 23.9 0.1 5.8e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT00325.1 - 0.1 12.3 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Cupin domain DUF4937 PF16291.5 ACT00325.1 - 0.21 11.9 1.4 7.1 6.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4937 FIVAR PF07554.13 ACT00326.1 - 2.7e-12 47.2 53.3 0.00028 21.6 1.6 5.3 5 0 0 5 5 5 4 FIVAR domain F5_F8_type_C PF00754.25 ACT00326.1 - 2.9e-08 33.9 10.9 0.0017 18.5 0.4 3.0 2 0 0 2 2 2 2 F5/8 type C domain DUF4972 PF16342.5 ACT00326.1 - 4.9e-08 32.7 0.1 0.0013 18.5 0.0 3.6 1 1 2 3 3 3 2 Domain of unknown function (DUF4972) Big_4 PF07532.11 ACT00326.1 - 4.7e-07 29.5 3.1 6.2e-06 25.9 0.1 3.3 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 4) Cohesin PF00963.18 ACT00326.1 - 1.4e-06 28.6 5.0 9.1e-06 26.0 0.0 4.3 4 0 0 4 4 4 1 Cohesin domain Big_9 PF17963.1 ACT00326.1 - 0.0041 17.8 3.4 0.0041 17.8 3.4 7.1 6 1 1 7 7 7 1 Bacterial Ig domain Inhibitor_I42 PF09394.10 ACT00326.1 - 0.01 16.2 6.7 4.4 7.8 0.4 5.1 4 0 0 4 4 4 0 Chagasin family peptidase inhibitor I42 He_PIG PF05345.12 ACT00326.1 - 0.26 11.5 4.7 12 6.2 1.1 3.9 2 0 0 2 2 2 0 Putative Ig domain SLH PF00395.20 ACT00327.1 - 3.2e-45 151.9 2.7 3.6e-16 58.9 0.1 3.3 3 0 0 3 3 3 3 S-layer homology domain Cohesin PF00963.18 ACT00327.1 - 9.6e-06 25.9 0.7 9.6e-06 25.9 0.7 1.9 2 1 1 3 3 3 1 Cohesin domain SBP_bac_8 PF13416.6 ACT00328.1 - 8.4e-35 121.0 14.6 1.2e-34 120.5 14.6 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT00328.1 - 4.1e-30 105.8 15.2 6.4e-30 105.2 15.2 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein YSIRK_signal PF04650.17 ACT00328.1 - 0.93 9.4 2.3 1.7 8.5 2.3 1.5 1 0 0 1 1 1 0 YSIRK type signal peptide BPD_transp_1 PF00528.22 ACT00329.1 - 1.8e-13 50.7 16.9 1.8e-13 50.7 16.9 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00330.1 - 5.4e-17 62.1 21.1 5.5e-16 58.8 14.0 2.0 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component DUF1772 PF08592.11 ACT00330.1 - 0.0059 16.9 13.7 0.32 11.3 2.3 3.1 2 1 1 3 3 3 2 Domain of unknown function (DUF1772) MNHE PF01899.16 ACT00330.1 - 0.068 12.9 0.1 0.068 12.9 0.1 2.9 3 0 0 3 3 3 0 Na+/H+ ion antiporter subunit DUF3328 PF11807.8 ACT00330.1 - 0.18 11.6 0.5 0.28 10.9 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) DUF5345 PF17280.2 ACT00330.1 - 3 7.9 7.5 0.13 12.2 1.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Sigma_reg_N PF13800.6 ACT00330.1 - 7.2 7.0 7.2 2.6 8.4 0.6 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal HemY_N PF07219.13 ACT00330.1 - 8.5 6.6 7.1 0.67 10.2 0.9 2.2 2 0 0 2 2 2 0 HemY protein N-terminus Response_reg PF00072.24 ACT00331.1 - 2.1e-25 89.0 0.2 4.1e-25 88.1 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00331.1 - 6.4e-20 71.2 0.1 1.2e-19 70.3 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00331.1 - 3.4e-17 62.1 0.2 2.9e-08 33.6 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF639 PF04842.12 ACT00331.1 - 0.07 12.5 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) His_kinase PF06580.13 ACT00332.1 - 5.6e-22 77.9 2.2 1.4e-21 76.6 2.2 1.7 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACT00332.1 - 3.6e-10 40.0 0.0 9.3e-10 38.7 0.0 1.8 1 0 0 1 1 1 1 HAMP domain dCache_1 PF02743.18 ACT00332.1 - 5.7e-08 32.9 3.9 1.2e-07 31.8 3.9 1.6 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT00332.1 - 1.2e-06 29.0 0.1 2.8e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PTPlike_phytase PF14566.6 ACT00332.1 - 0.12 12.5 0.3 0.36 10.9 0.1 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate BPD_transp_1 PF00528.22 ACT00333.1 - 2.7e-13 50.1 8.7 2.7e-13 50.1 8.7 2.5 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Bac_export_2 PF01312.19 ACT00333.1 - 0.1 11.8 6.8 1.7 7.8 5.5 2.3 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family BPD_transp_1 PF00528.22 ACT00334.1 - 3.4e-15 56.3 22.4 7.3e-14 51.9 22.6 2.4 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF5353 PF17304.2 ACT00334.1 - 0.18 11.6 1.0 0.35 10.6 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5353) Defb50 PF17546.2 ACT00335.1 - 0.08 12.9 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 Beta defensin 50 Glyco_hydro_31 PF01055.26 ACT00337.1 - 1.5e-98 330.9 14.0 2.4e-98 330.2 14.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 ACT00337.1 - 3.5e-09 36.8 0.0 1.6e-08 34.7 0.0 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) DUF4968 PF16338.5 ACT00337.1 - 7.3e-08 32.6 0.0 1.8e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4968) TPR_MalT PF17874.1 ACT00338.1 - 9.3e-36 123.9 10.6 2.2e-33 116.1 8.0 2.5 2 0 0 2 2 2 2 MalT-like TPR region GerE PF00196.19 ACT00338.1 - 6e-18 64.1 0.1 1.2e-17 63.2 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family AAA_16 PF13191.6 ACT00338.1 - 2.2e-05 24.9 2.6 0.00017 22.0 0.0 3.2 3 1 0 3 3 3 1 AAA ATPase domain TPR_19 PF14559.6 ACT00338.1 - 6.6e-05 23.3 25.2 0.16 12.5 0.1 6.9 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 ACT00338.1 - 0.00012 21.9 17.0 1.1 9.5 0.3 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 ACT00338.1 - 0.00014 22.0 21.3 0.02 15.2 2.8 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ACT00338.1 - 0.00018 21.5 9.0 1.1 9.7 0.0 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat Sigma70_r4 PF04545.16 ACT00338.1 - 0.0006 19.3 0.5 0.0061 16.1 0.1 2.7 2 0 0 2 2 2 1 Sigma-70, region 4 ANAPC3 PF12895.7 ACT00338.1 - 0.0011 19.1 1.0 0.033 14.4 0.1 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 ACT00338.1 - 0.0021 17.8 1.7 0.046 13.4 0.2 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat-like domain Sigma70_r4_2 PF08281.12 ACT00338.1 - 0.0045 16.6 0.0 0.013 15.2 0.0 1.9 1 0 0 1 1 1 1 Sigma-70, region 4 AAA_22 PF13401.6 ACT00338.1 - 0.06 13.6 0.0 0.33 11.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain TPR_14 PF13428.6 ACT00338.1 - 0.071 14.0 23.8 7.2 7.7 0.1 7.5 7 0 0 7 7 7 0 Tetratricopeptide repeat AAA_25 PF13481.6 ACT00338.1 - 0.31 10.6 6.2 0.48 10.0 0.0 3.5 4 0 0 4 4 4 0 AAA domain TPR_4 PF07721.14 ACT00338.1 - 2.8 8.8 20.3 2.3 9.1 2.9 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat SspH PF08141.12 ACT00339.1 - 1.8e-21 76.0 0.0 2.2e-21 75.7 0.0 1.1 1 0 0 1 1 1 1 Small acid-soluble spore protein H family Trehalase PF01204.18 ACT00340.1 - 6.4e-09 35.2 0.0 9.7e-09 34.6 0.0 1.2 1 0 0 1 1 1 1 Trehalase Glyco_hydro_63 PF03200.16 ACT00340.1 - 1e-06 27.8 4.9 0.0013 17.6 0.0 3.9 2 1 1 3 3 3 3 Glycosyl hydrolase family 63 C-terminal domain Bac_rhamnosid6H PF17389.2 ACT00340.1 - 0.00014 21.2 0.0 0.00023 20.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain His_kinase PF06580.13 ACT00341.1 - 3.1e-21 75.5 0.6 7.4e-21 74.3 0.6 1.7 1 0 0 1 1 1 1 Histidine kinase HATPase_c PF02518.26 ACT00341.1 - 4.3e-08 33.7 0.0 9.2e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACT00341.1 - 1.1e-07 31.9 1.4 1.7e-07 31.3 1.4 1.3 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 ACT00341.1 - 1.4e-05 25.3 0.0 4.2e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 HAMP domain HATPase_c_2 PF13581.6 ACT00341.1 - 0.038 13.9 0.0 0.076 13.0 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain NMT1 PF09084.11 ACT00341.1 - 0.15 11.9 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 NMT1/THI5 like NapE PF06796.11 ACT00341.1 - 0.44 10.1 2.1 0.49 10.0 0.2 1.9 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE 4HB_MCP_1 PF12729.7 ACT00341.1 - 1.4 8.4 5.2 0.99 8.9 0.4 2.4 2 1 1 3 3 3 0 Four helix bundle sensory module for signal transduction Response_reg PF00072.24 ACT00342.1 - 1.3e-26 92.9 0.0 2e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00342.1 - 5.4e-19 68.3 0.2 1e-18 67.4 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00342.1 - 6.2e-18 64.4 0.1 2.2e-08 34.0 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_23 PF13384.6 ACT00342.1 - 6.3e-05 22.6 0.1 0.032 14.0 0.0 2.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_IclR PF09339.10 ACT00342.1 - 0.0012 18.5 0.0 1.3 8.9 0.0 3.0 3 0 0 3 3 3 2 IclR helix-turn-helix domain HTH_AsnC-type PF13404.6 ACT00342.1 - 0.0013 18.5 0.1 1.7 8.6 0.0 2.5 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain MarR_2 PF12802.7 ACT00342.1 - 0.0034 17.2 0.0 0.28 11.1 0.0 2.4 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.6 ACT00342.1 - 0.005 16.4 0.0 0.58 9.8 0.0 2.5 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding TetR_N PF00440.23 ACT00342.1 - 0.0096 15.7 0.0 2 8.3 0.0 2.4 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family HTH_Tnp_ISL3 PF13542.6 ACT00342.1 - 0.02 14.3 0.1 7.2 6.1 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_Tnp_1 PF01527.20 ACT00342.1 - 0.029 14.7 0.1 1.2 9.5 0.0 2.8 2 0 0 2 2 2 0 Transposase HTH_29 PF13551.6 ACT00342.1 - 0.035 14.1 0.0 3.9 7.6 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn helix Sigma70_r4 PF04545.16 ACT00342.1 - 0.052 13.1 0.0 9.9 5.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_Tnp_1_2 PF13022.6 ACT00342.1 - 0.07 13.3 0.3 40 4.4 0.0 3.7 3 1 1 4 4 4 0 Helix-turn-helix of insertion element transposase HTH_35 PF13693.6 ACT00342.1 - 0.1 12.6 0.3 9.3 6.4 0.0 3.0 2 2 1 3 3 3 0 Winged helix-turn-helix DNA-binding HTH_31 PF13560.6 ACT00342.1 - 0.14 12.5 0.2 13 6.2 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain SBP_bac_1 PF01547.25 ACT00343.1 - 3.1e-39 135.8 17.8 3.1e-39 135.8 17.8 1.8 2 1 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT00343.1 - 4.5e-32 112.0 10.2 6e-32 111.6 10.2 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein PPR_2 PF13041.6 ACT00343.1 - 0.053 13.7 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 PPR repeat family BPD_transp_1 PF00528.22 ACT00344.1 - 6.7e-18 65.1 18.9 6.7e-18 65.1 18.9 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component PDR_assoc PF08370.11 ACT00344.1 - 0.024 14.4 0.3 0.024 14.4 0.3 3.2 3 0 0 3 3 3 0 Plant PDR ABC transporter associated BPD_transp_1 PF00528.22 ACT00345.1 - 6.4e-18 65.1 10.4 6.4e-18 65.1 10.4 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Glyco_hydro_2_C PF02836.17 ACT00346.1 - 1.1e-110 369.5 0.0 1.6e-110 369.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 ACT00346.1 - 7.4e-77 258.2 0.0 1.1e-76 257.7 0.0 1.3 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 ACT00346.1 - 7.1e-51 172.5 0.9 1.2e-50 171.7 0.9 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 ACT00346.1 - 6.6e-24 84.2 0.0 4.1e-23 81.7 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 ACT00346.1 - 5.3e-15 56.0 0.0 9.1e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_72 PF03198.14 ACT00346.1 - 0.0011 18.3 0.0 0.0018 17.6 0.0 1.3 1 0 0 1 1 1 1 Glucanosyltransferase MFS_1 PF07690.16 ACT00347.1 - 6.8e-31 107.5 37.0 2e-26 92.8 27.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ACT00347.1 - 2.4e-12 46.2 23.8 5.4e-12 45.0 18.6 2.1 1 1 1 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 ACT00347.1 - 1.4e-05 24.2 28.7 0.00098 18.1 9.2 3.2 1 1 2 3 3 3 2 MFS_1 like family Sugar_tr PF00083.24 ACT00347.1 - 0.0007 18.6 29.8 0.0012 17.8 3.4 3.5 2 2 1 3 3 3 3 Sugar (and other) transporter UNC-93 PF05978.16 ACT00347.1 - 0.0078 15.9 3.3 0.0078 15.9 3.3 2.8 2 1 0 2 2 2 2 Ion channel regulatory protein UNC-93 ATG22 PF11700.8 ACT00347.1 - 0.011 14.5 21.8 0.019 13.6 11.0 2.2 2 0 0 2 2 2 0 Vacuole effluxer Atg22 like DBI_PRT PF02277.17 ACT00347.1 - 0.13 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyltransferase HTH_18 PF12833.7 ACT00348.1 - 4.5e-23 81.3 0.1 1.4e-22 79.7 0.1 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00348.1 - 2.5e-08 33.8 0.0 2.7e-05 24.1 0.0 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family dCache_1 PF02743.18 ACT00348.1 - 3.3e-08 33.6 0.8 9.9e-08 32.1 0.3 2.0 2 0 0 2 2 2 1 Cache domain GGDEF_2 PF17853.1 ACT00348.1 - 1.1e-07 32.1 0.1 7.5e-07 29.4 0.1 2.3 2 0 0 2 2 2 1 GGDEF-like domain DUF1400 PF07176.11 ACT00348.1 - 8.3e-05 22.9 0.2 0.00026 21.3 0.2 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1400) DUF445 PF04286.12 ACT00348.1 - 0.019 14.8 1.2 0.33 10.7 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF445) DUF2244 PF10003.9 ACT00348.1 - 0.19 11.4 0.7 3.9 7.1 0.0 2.4 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) BPD_transp_1 PF00528.22 ACT00349.1 - 2.2e-14 53.6 15.8 2.2e-14 53.6 15.8 2.2 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00350.1 - 1.2e-15 57.8 15.9 1.2e-15 57.8 15.9 1.8 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component ATP1G1_PLM_MAT8 PF02038.16 ACT00350.1 - 0.19 11.2 2.9 0.42 10.1 0.8 2.3 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family SBP_bac_1 PF01547.25 ACT00351.1 - 1e-18 68.4 12.8 1e-18 68.4 12.8 2.0 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT00351.1 - 0.0007 19.1 0.2 0.06 12.8 0.0 2.4 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein GcpE PF04551.14 ACT00351.1 - 0.04 13.0 0.0 0.061 12.4 0.0 1.2 1 0 0 1 1 1 0 GcpE protein SBP_bac_11 PF13531.6 ACT00351.1 - 0.055 13.2 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein Glyco_hydro_43 PF04616.14 ACT00352.1 - 9.1e-19 67.9 0.4 1.4e-18 67.2 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 ACT00352.1 - 2.1e-12 47.2 0.0 5.4e-08 32.8 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_130 PF04041.13 ACT00352.1 - 2.8e-06 26.5 0.0 0.0016 17.4 0.0 2.8 1 1 2 3 3 3 3 beta-1,4-mannooligosaccharide phosphorylase BNR_2 PF13088.6 ACT00352.1 - 2.1e-05 24.0 0.0 0.003 16.9 0.0 2.1 2 0 0 2 2 2 2 BNR repeat-like domain MerR_1 PF13411.6 ACT00353.1 - 2.3e-20 72.4 0.0 4.3e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT00353.1 - 5.5e-17 61.2 0.0 6.4e-15 54.6 0.0 2.2 2 0 0 2 2 2 2 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT00353.1 - 1.4e-05 25.6 0.0 2e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 MerR, DNA binding HTH_17 PF12728.7 ACT00353.1 - 0.00058 20.0 0.0 0.0017 18.5 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain adh_short PF00106.25 ACT00354.1 - 7.5e-52 175.6 0.1 1e-51 175.2 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT00354.1 - 4.5e-38 131.1 0.0 5.7e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT00354.1 - 4.8e-11 42.9 0.0 6.9e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 ACT00354.1 - 0.0058 15.8 0.0 0.0078 15.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 ACT00354.1 - 0.011 15.1 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DFP PF04127.15 ACT00354.1 - 0.06 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein DUF5440 PF17509.2 ACT00354.1 - 0.11 12.0 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5440) DUF3862 PF12978.7 ACT00355.1 - 2.4e-08 33.9 0.2 2.9e-08 33.7 0.2 1.1 1 0 0 1 1 1 1 Domain of Unknown Function with PDB structure (DUF3862) SmpA_OmlA PF04355.13 ACT00355.1 - 0.00045 20.0 0.1 0.00072 19.3 0.1 1.3 1 0 0 1 1 1 1 SmpA / OmlA family BLIP PF07467.11 ACT00355.1 - 0.00085 19.9 0.4 0.0017 19.0 0.0 1.6 2 0 0 2 2 2 1 Beta-lactamase inhibitor (BLIP) DUF228 PF02989.14 ACT00355.1 - 0.012 15.4 0.2 0.016 15.0 0.2 1.2 1 0 0 1 1 1 0 Lyme disease proteins of unknown function DUF4576 PF15144.6 ACT00355.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4576) adh_short PF00106.25 ACT00356.1 - 1.2e-61 207.6 2.6 1.4e-61 207.4 2.6 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT00356.1 - 7.4e-44 150.1 1.3 9e-44 149.8 1.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT00356.1 - 3.3e-16 59.7 0.2 4.2e-16 59.4 0.2 1.1 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 ACT00356.1 - 0.00059 19.9 0.1 0.0012 18.9 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NmrA PF05368.13 ACT00356.1 - 0.011 15.4 0.7 0.028 14.0 0.7 1.7 1 0 0 1 1 1 0 NmrA-like family NAD_binding_10 PF13460.6 ACT00356.1 - 0.012 15.5 2.4 0.021 14.7 2.4 1.5 1 1 0 1 1 1 0 NAD(P)H-binding 3HCDH_N PF02737.18 ACT00356.1 - 0.027 14.3 0.4 0.048 13.5 0.4 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ACT00356.1 - 0.063 12.6 0.3 0.1 11.9 0.3 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 ACT00356.1 - 0.096 12.1 1.1 0.48 9.8 1.1 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Exog_C PF18026.1 ACT00356.1 - 0.16 12.0 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 Endo/exonuclease (EXOG) C-terminal domain Peripla_BP_1 PF00532.21 ACT00357.1 - 6.4e-25 88.1 0.0 9.4e-25 87.6 0.0 1.3 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT00357.1 - 1.2e-20 73.0 0.7 2.2e-20 72.2 0.7 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_3 PF13377.6 ACT00357.1 - 1.7e-18 67.5 0.0 5.6e-18 65.8 0.0 1.8 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_4 PF13407.6 ACT00357.1 - 5.5e-05 22.9 0.0 0.003 17.2 0.0 2.5 1 1 0 1 1 1 1 Periplasmic binding protein domain HTH_38 PF13936.6 ACT00357.1 - 0.00023 20.8 0.1 0.0016 18.1 0.1 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_7 PF02796.15 ACT00357.1 - 0.0017 18.4 0.0 0.0043 17.1 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_Tnp_ISL3 PF13542.6 ACT00357.1 - 0.0083 15.5 0.1 0.017 14.6 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 ACT00357.1 - 0.03 14.1 0.0 0.073 12.9 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain HTH_31 PF13560.6 ACT00357.1 - 0.032 14.6 0.0 0.059 13.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.6 ACT00357.1 - 0.04 13.5 0.1 0.089 12.4 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TetR_N PF00440.23 ACT00357.1 - 0.053 13.3 0.2 0.17 11.7 0.1 1.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family HTH_36 PF13730.6 ACT00357.1 - 0.071 13.1 0.0 0.5 10.4 0.0 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_3 PF01381.22 ACT00357.1 - 0.085 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix MarR PF01047.22 ACT00357.1 - 0.086 12.8 0.1 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 MarR family HTH_Crp_2 PF13545.6 ACT00357.1 - 0.09 12.8 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain CENP-B_N PF04218.13 ACT00357.1 - 0.1 12.3 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Trp_repressor PF01371.19 ACT00357.1 - 0.12 12.5 0.1 0.45 10.7 0.1 1.9 2 0 0 2 2 2 0 Trp repressor protein HTH_IclR PF09339.10 ACT00357.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain HAD_2 PF13419.6 ACT00358.1 - 3.7e-25 89.0 0.0 4.3e-22 79.1 0.0 2.0 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT00358.1 - 2e-08 34.8 0.0 0.0001 22.6 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT00358.1 - 1.1e-05 25.4 0.0 1.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ACT00358.1 - 0.00025 21.5 0.3 0.57 10.6 0.1 2.2 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase NIF PF03031.18 ACT00358.1 - 0.13 12.0 0.0 0.15 11.8 0.0 1.3 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase DUF2608 PF11019.8 ACT00358.1 - 0.15 11.5 0.0 2.3 7.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) HATPase_c PF02518.26 ACT00359.1 - 4.5e-24 85.1 0.0 1e-23 84.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT00359.1 - 1.8e-14 53.5 0.0 5.5e-14 52.0 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT00359.1 - 2.5e-13 50.2 0.2 7.2e-13 48.7 0.2 1.9 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 ACT00359.1 - 0.00018 21.3 0.1 0.00037 20.3 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Glutaredoxin2_C PF04399.13 ACT00359.1 - 0.0041 17.0 0.6 0.061 13.2 0.0 2.7 3 0 0 3 3 3 1 Glutaredoxin 2, C terminal domain HATPase_c_5 PF14501.6 ACT00359.1 - 0.0048 16.8 0.4 0.012 15.5 0.1 1.8 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.6 ACT00359.1 - 0.039 13.9 0.0 0.095 12.7 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Response_reg PF00072.24 ACT00360.1 - 2.2e-29 101.9 0.3 3.5e-29 101.2 0.3 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT00360.1 - 2.3e-26 91.6 0.0 5e-26 90.6 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal BacA PF02673.18 ACT00361.1 - 1.5e-79 267.3 17.4 1.8e-79 267.1 17.4 1.0 1 0 0 1 1 1 1 Bacitracin resistance protein BacA DUF3995 PF13160.6 ACT00361.1 - 0.0056 17.0 2.0 0.0056 17.0 2.0 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3995) SNARE_assoc PF09335.11 ACT00362.1 - 2.9e-25 89.1 7.6 2.9e-25 89.1 7.6 1.9 3 0 0 3 3 3 1 SNARE associated Golgi protein CcmD PF04995.14 ACT00362.1 - 1.7 8.8 7.4 0.21 11.7 2.6 2.1 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) ACR_tran PF00873.19 ACT00364.1 - 4.2e-175 584.2 38.9 5.9e-175 583.7 38.9 1.1 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family SecD_SecF PF02355.16 ACT00364.1 - 3.4e-13 49.4 34.5 2.6e-07 30.2 11.5 2.5 2 0 0 2 2 2 2 Protein export membrane protein CBS PF00571.28 ACT00364.1 - 0.088 13.3 0.1 0.41 11.1 0.1 2.1 1 0 0 1 1 1 0 CBS domain FeS_assembly_P PF01883.19 ACT00364.1 - 0.2 11.9 2.1 11 6.3 0.1 4.3 4 0 0 4 4 4 0 Iron-sulfur cluster assembly protein DUF2937 PF11157.8 ACT00364.1 - 0.36 10.5 4.3 7.8 6.2 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2937) SPC12 PF06645.13 ACT00364.1 - 2.3 8.4 15.3 13 6.0 1.6 3.7 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Herpes_LMP1 PF05297.11 ACT00364.1 - 6.3 5.9 5.7 16 4.6 5.7 1.6 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Sigma70_r2 PF04542.14 ACT00365.1 - 2.3e-17 62.5 0.3 3.6e-17 61.9 0.3 1.3 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT00365.1 - 6.3e-14 51.4 0.0 1.3e-13 50.3 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT00365.1 - 1.4e-09 37.3 0.1 2.6e-09 36.4 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACT00365.1 - 1.7e-08 34.6 0.4 1.3e-07 31.7 0.4 1.9 1 1 0 1 1 1 1 ECF sigma factor HTH_16 PF12645.7 ACT00365.1 - 3.4e-05 23.8 0.1 6.3e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 ACT00365.1 - 0.001 18.8 0.1 0.0035 17.1 0.0 1.9 2 0 0 2 2 2 1 Homeodomain-like domain GerE PF00196.19 ACT00365.1 - 0.14 11.7 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family zf-HC2 PF13490.6 ACT00366.1 - 5.5e-13 48.9 1.7 1e-12 48.1 1.7 1.4 1 0 0 1 1 1 1 Putative zinc-finger DUF1449 PF07290.11 ACT00366.1 - 0.018 14.7 2.0 0.021 14.5 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1449) RseA_N PF03872.13 ACT00366.1 - 0.033 14.7 0.2 0.07 13.6 0.2 1.5 2 0 0 2 2 2 0 Anti sigma-E protein RseA, N-terminal domain DUF2842 PF11003.8 ACT00366.1 - 0.86 9.9 6.0 0.53 10.6 4.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2842) Kelch_4 PF13418.6 ACT00367.1 - 0.058 13.4 0.8 0.76 9.8 0.2 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ACT00367.1 - 0.73 9.5 4.3 3 7.5 0.3 2.5 2 0 0 2 2 2 0 Kelch motif DUF2512 PF10710.9 ACT00367.1 - 6.1 6.5 9.2 14 5.3 9.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2512) KAAG1 PF15354.6 ACT00368.1 - 0.15 12.7 0.0 0.16 12.5 0.0 1.1 1 0 0 1 1 1 0 Kidney-associated antigen 1 Translat_reg PF01818.17 ACT00369.1 - 0.026 14.5 0.0 0.031 14.3 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage translational regulator Sulfatase PF00884.23 ACT00370.1 - 3.9e-58 197.3 0.1 4.9e-58 197.0 0.1 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACT00370.1 - 3.5e-11 43.3 0.2 4.4e-10 39.7 0.2 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 ACT00370.1 - 3.3e-10 40.1 0.1 1.3e-09 38.3 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) DUF229 PF02995.17 ACT00370.1 - 3.6e-05 22.6 0.3 5.7e-05 21.9 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) ELFV_dehydrog PF00208.21 ACT00371.1 - 2.5e-87 292.6 3.9 3.2e-87 292.3 3.9 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 ACT00371.1 - 5.7e-51 171.8 0.0 1.1e-50 170.8 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain AlaDh_PNT_C PF01262.21 ACT00371.1 - 0.29 10.4 3.7 0.15 11.3 0.3 2.2 2 1 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain LysR_substrate PF03466.20 ACT00372.1 - 3.7e-48 163.7 0.0 7.3e-48 162.7 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT00372.1 - 6e-20 71.0 0.1 1.3e-19 69.9 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 ACT00372.1 - 0.014 15.2 0.2 0.041 13.8 0.1 1.9 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 ACT00372.1 - 0.13 12.2 1.1 0.19 11.6 0.1 1.8 2 0 0 2 2 2 0 MarR family HTH_30 PF13556.6 ACT00372.1 - 0.15 11.9 0.1 0.35 10.7 0.1 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain GerA PF03323.13 ACT00373.1 - 2.1e-155 517.8 3.9 2.4e-155 517.6 3.9 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Reprolysin_4 PF13583.6 ACT00373.1 - 0.19 11.3 0.1 0.33 10.6 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Spore_GerAC PF05504.11 ACT00374.1 - 1.1e-26 94.0 0.1 2.2e-25 89.8 0.0 2.1 2 0 0 2 2 2 1 Spore germination B3/ GerAC like, C-terminal Spore_permease PF03845.13 ACT00375.1 - 2.1e-71 240.4 39.3 2.1e-71 240.4 39.3 1.3 2 0 0 2 2 2 1 Spore germination protein PsbW PF07123.12 ACT00375.1 - 1.1 9.3 3.5 4.7 7.2 3.5 2.0 1 1 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) YjfB_motility PF14070.6 ACT00376.1 - 5.6e-22 77.7 6.7 6.1e-22 77.5 6.7 1.0 1 0 0 1 1 1 1 Putative motility protein DoxX_2 PF13564.6 ACT00377.1 - 7.6e-20 71.0 8.5 9.5e-20 70.6 8.5 1.1 1 0 0 1 1 1 1 DoxX-like family DoxX PF07681.12 ACT00377.1 - 4.5e-05 24.0 3.4 4.5e-05 24.0 3.4 1.8 1 1 1 2 2 2 1 DoxX DUF4149 PF13664.6 ACT00377.1 - 0.0069 16.7 4.0 0.0069 16.7 4.0 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4149) Abhydrolase_3 PF07859.13 ACT00378.1 - 1.8e-68 230.5 0.1 2.2e-68 230.3 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ACT00378.1 - 2e-06 27.5 0.1 0.035 13.6 0.1 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase_phd PF10503.9 ACT00378.1 - 0.0017 17.9 0.1 0.0078 15.7 0.1 2.0 2 1 0 2 2 2 1 Esterase PHB depolymerase COesterase PF00135.28 ACT00378.1 - 0.0053 15.7 0.0 0.015 14.2 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family AXE1 PF05448.12 ACT00378.1 - 0.029 13.1 0.0 1.9 7.0 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Gp_dh_C PF02800.20 ACT00379.1 - 7e-41 139.5 0.0 9.1e-41 139.1 0.0 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ACT00379.1 - 6.6e-20 71.3 0.0 1.1e-19 70.6 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 ACT00379.1 - 0.14 12.8 0.0 0.81 10.4 0.0 2.1 1 1 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.20 ACT00379.1 - 0.15 12.2 0.0 0.68 10.1 0.0 2.0 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ABC_tran PF00005.27 ACT00380.1 - 2.7e-32 112.1 0.0 4.3e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00380.1 - 1.8e-09 37.8 0.7 0.00029 20.7 0.1 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 ACT00380.1 - 2.8e-06 27.8 0.1 3.3e-05 24.3 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ACT00380.1 - 1.6e-05 24.6 0.1 3.4e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 ACT00380.1 - 3.5e-05 23.3 0.0 0.25 10.8 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT00380.1 - 0.00026 21.3 0.2 0.034 14.4 0.1 2.2 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ACT00380.1 - 0.00031 20.7 0.0 0.00056 19.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ACT00380.1 - 0.0015 19.0 0.1 0.0028 18.1 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 ACT00380.1 - 0.011 15.5 0.0 0.15 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 ACT00380.1 - 0.013 16.0 0.1 0.019 15.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ACT00380.1 - 0.017 14.7 0.1 0.037 13.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 ACT00380.1 - 0.023 14.6 0.1 0.047 13.6 0.0 1.5 2 0 0 2 2 1 0 Rad17 P-loop domain AAA_18 PF13238.6 ACT00380.1 - 0.024 15.2 0.0 0.35 11.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ACT00380.1 - 0.027 14.2 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.14 ACT00380.1 - 0.052 13.5 0.0 0.17 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ACT00380.1 - 0.065 13.6 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase ABC_ATPase PF09818.9 ACT00380.1 - 0.075 11.8 0.0 1.7 7.3 0.0 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class NB-ARC PF00931.22 ACT00380.1 - 0.1 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain ATPase_2 PF01637.18 ACT00380.1 - 0.13 12.2 0.0 1.2 8.9 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 ACT00380.1 - 0.13 12.3 0.0 0.41 10.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ACT00380.1 - 0.18 12.1 0.0 47 4.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 ACT00380.1 - 0.21 11.3 0.0 0.75 9.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 ACT00380.1 - 0.21 11.8 0.3 0.69 10.2 0.3 1.8 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit BPD_transp_1 PF00528.22 ACT00381.1 - 5.8e-21 75.1 16.2 5.8e-21 75.1 16.2 2.3 1 1 1 3 3 3 1 Binding-protein-dependent transport system inner membrane component Bac_luciferase PF00296.20 ACT00382.1 - 4e-67 226.9 0.7 4.9e-67 226.6 0.7 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase NMT1 PF09084.11 ACT00383.1 - 2.3e-22 80.0 0.2 3.2e-22 79.5 0.2 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 ACT00383.1 - 2.4e-08 34.0 0.0 3.7e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.20 ACT00383.1 - 9.1e-05 22.0 0.1 0.00014 21.4 0.1 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Bac_luciferase PF00296.20 ACT00384.1 - 3.6e-65 220.4 0.3 4.6e-65 220.1 0.3 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Unstab_antitox PF09720.10 ACT00384.1 - 0.088 12.9 0.2 0.23 11.6 0.2 1.7 1 0 0 1 1 1 0 Putative addiction module component adh_short PF00106.25 ACT00385.1 - 1.7e-19 70.0 0.2 4e-19 68.8 0.2 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT00385.1 - 8.6e-17 61.5 0.0 1.9e-16 60.4 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT00385.1 - 0.064 13.2 0.6 0.1 12.5 0.6 1.2 1 0 0 1 1 1 0 KR domain THF_DHG_CYH_C PF02882.19 ACT00385.1 - 0.071 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain WYL PF13280.6 ACT00386.1 - 6.8e-36 123.9 0.0 9.6e-36 123.4 0.0 1.2 1 0 0 1 1 1 1 WYL domain HTH_11 PF08279.12 ACT00386.1 - 2e-13 50.1 0.2 4e-13 49.1 0.2 1.5 1 0 0 1 1 1 1 HTH domain Rrf2 PF02082.20 ACT00386.1 - 2.3e-05 24.6 0.0 5.4e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulator HTH_DeoR PF08220.12 ACT00386.1 - 3.6e-05 23.4 0.3 7.2e-05 22.4 0.3 1.5 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_24 PF13412.6 ACT00386.1 - 0.0043 16.6 1.0 0.0075 15.8 1.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 ACT00386.1 - 0.015 15.1 0.3 0.03 14.2 0.3 1.5 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_Mga PF08280.11 ACT00386.1 - 0.057 13.5 0.4 0.14 12.3 0.4 1.6 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_29 PF13551.6 ACT00386.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix Glyco_hydro_43 PF04616.14 ACT00387.1 - 4e-52 177.3 14.2 5.8e-52 176.8 14.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 CBM_35 PF16990.5 ACT00387.1 - 0.00012 22.4 1.2 0.00033 20.9 1.2 1.8 1 0 0 1 1 1 1 Carbohydrate binding module (family 35) peroxidase PF00141.23 ACT00388.1 - 4.5e-93 311.2 0.0 1.8e-50 171.8 0.0 2.2 2 0 0 2 2 2 2 Peroxidase HTH_18 PF12833.7 ACT00389.1 - 5.2e-20 71.5 0.1 4.9e-19 68.4 0.0 2.6 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00389.1 - 9.7e-11 41.5 0.0 1.8e-06 27.9 0.0 2.9 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT00389.1 - 1.2e-08 35.2 0.0 3.2e-08 33.8 0.0 1.8 1 0 0 1 1 1 1 GGDEF-like domain dCache_1 PF02743.18 ACT00389.1 - 2e-06 27.8 0.5 2e-06 27.8 0.5 2.1 2 0 0 2 2 2 1 Cache domain DHC PF09626.10 ACT00389.1 - 0.00023 22.0 0.0 0.00064 20.6 0.0 1.8 1 0 0 1 1 1 1 Dihaem cytochrome c DUF677 PF05055.12 ACT00389.1 - 0.0029 16.6 0.1 0.0057 15.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF677) DegS PF05384.11 ACT00389.1 - 0.0069 15.9 0.3 0.025 14.1 0.3 2.0 1 0 0 1 1 1 1 Sensor protein DegS zf-3CxxC PF13695.6 ACT00389.1 - 0.13 12.8 0.4 0.3 11.6 0.1 1.7 2 0 0 2 2 2 0 Zinc-binding domain SBP_bac_1 PF01547.25 ACT00390.1 - 3.3e-20 73.3 8.8 3.3e-20 73.3 8.8 1.7 2 1 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT00390.1 - 2.9e-17 63.4 3.5 2.9e-17 63.4 3.5 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT00391.1 - 2.6e-12 46.8 19.9 2.6e-12 46.8 19.9 2.5 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF5326 PF17260.2 ACT00391.1 - 1.7 8.9 11.3 0.11 12.6 1.2 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF5326) BPD_transp_1 PF00528.22 ACT00392.1 - 1.8e-16 60.4 12.7 1.8e-16 60.4 12.7 2.5 1 1 2 3 3 3 1 Binding-protein-dependent transport system inner membrane component ABC2_membrane_3 PF12698.7 ACT00392.1 - 1.3 8.0 27.4 2 7.5 26.7 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein AP_endonuc_2 PF01261.24 ACT00393.1 - 3.2e-18 65.9 0.0 4.6e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel RcsD_ABL PF16359.5 ACT00393.1 - 0.019 15.1 0.0 0.17 12.0 0.0 2.2 2 0 0 2 2 2 0 RcsD-ABL domain Radical_SAM PF04055.21 ACT00393.1 - 0.072 13.5 0.2 0.58 10.5 0.0 2.4 2 1 1 3 3 3 0 Radical SAM superfamily Glyco_hydro_88 PF07470.13 ACT00396.1 - 1.9e-67 227.8 1.8 2.7e-67 227.3 1.8 1.2 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 MgtC PF02308.16 ACT00397.1 - 1.2e-20 74.1 7.9 1.6e-20 73.7 7.9 1.1 1 0 0 1 1 1 1 MgtC family PrgI PF12666.7 ACT00397.1 - 0.074 13.8 0.3 0.14 12.9 0.3 1.5 1 0 0 1 1 1 0 PrgI family protein GFO_IDH_MocA PF01408.22 ACT00398.1 - 1.9e-12 48.0 0.0 3.4e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 ACT00398.1 - 0.026 15.1 0.0 0.055 14.0 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent VanZ PF04892.12 ACT00399.1 - 1.7e-24 86.9 3.8 2.2e-24 86.5 3.8 1.1 1 0 0 1 1 1 1 VanZ like family NEAT PF05031.12 ACT00400.1 - 1e-60 203.6 20.5 1.6e-26 93.2 3.3 3.5 3 0 0 3 3 3 3 Iron Transport-associated domain SLH PF00395.20 ACT00400.1 - 4.1e-41 138.7 3.7 1.5e-15 56.9 0.1 3.8 3 0 0 3 3 3 3 S-layer homology domain DUF4972 PF16342.5 ACT00400.1 - 3.5e-07 30.0 0.1 0.092 12.4 0.0 3.9 3 1 0 3 3 3 3 Domain of unknown function (DUF4972) Pox_P35 PF03213.14 ACT00400.1 - 0.19 10.9 1.7 0.16 11.1 0.1 1.6 2 0 0 2 2 2 0 Poxvirus P35 protein INCENP_ARK-bind PF03941.15 ACT00400.1 - 0.25 11.3 0.8 16 5.6 0.2 2.5 2 0 0 2 2 2 0 Inner centromere protein, ARK binding region OMP_b-brl PF13505.6 ACT00401.1 - 0.0012 19.0 8.2 0.0015 18.7 8.2 1.0 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain TIG PF01833.24 ACT00401.1 - 0.0036 17.4 1.0 0.0056 16.7 0.5 1.5 2 0 0 2 2 2 1 IPT/TIG domain tRNA_anti-like PF12869.7 ACT00401.1 - 0.17 11.5 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 tRNA_anti-like ABM PF03992.16 ACT00402.1 - 5.6e-16 58.4 0.0 6.5e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF1330 PF07045.11 ACT00402.1 - 0.082 13.2 0.2 0.11 12.8 0.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1330) NEAT PF05031.12 ACT00403.1 - 1.9e-32 112.4 0.5 2.9e-32 111.8 0.5 1.3 1 0 0 1 1 1 1 Iron Transport-associated domain SRP-alpha_N PF04086.13 ACT00403.1 - 0.64 9.9 6.1 0.86 9.5 6.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ndc1_Nup PF09531.10 ACT00403.1 - 3.8 6.1 5.3 4.6 5.8 5.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup XhlA PF10779.9 ACT00403.1 - 6.4 7.1 6.2 13 6.1 6.2 1.5 1 0 0 1 1 1 0 Haemolysin XhlA Response_reg PF00072.24 ACT00404.1 - 1.6e-24 86.2 0.0 2.5e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT00404.1 - 1.2e-23 82.9 0.1 3.5e-23 81.5 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal OKR_DC_1_N PF03709.15 ACT00404.1 - 0.019 15.2 0.0 0.041 14.2 0.0 1.6 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain HATPase_c PF02518.26 ACT00405.1 - 2.7e-27 95.5 0.0 5.1e-27 94.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT00405.1 - 3.3e-16 59.4 0.0 7.9e-16 58.2 0.0 1.7 1 0 0 1 1 1 1 HAMP domain HisKA PF00512.25 ACT00405.1 - 9.4e-13 48.0 1.0 2e-12 47.0 0.7 1.8 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 ACT00405.1 - 5.7e-05 23.0 0.0 0.00015 21.6 0.0 1.7 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 ACT00405.1 - 0.068 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Lig_C PF18330.1 ACT00405.1 - 0.12 12.4 0.0 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 Ligase Pab1020 C-terminal region Glyco_hydro_31 PF01055.26 ACT00406.1 - 2.1e-45 155.7 0.0 2.4e-44 152.2 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 HTH_AraC PF00165.23 ACT00407.1 - 6.1e-22 77.2 0.6 1.4e-09 37.8 0.0 3.0 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT00407.1 - 4.7e-21 74.8 0.1 8.7e-21 74.0 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT00407.1 - 1.1e-12 48.0 0.0 1.7e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Glyco_trans_A_1 PF09318.10 ACT00407.1 - 0.034 13.8 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase 1 domain A Arc_PepC PF06819.11 ACT00407.1 - 0.042 14.0 0.0 0.073 13.2 0.0 1.3 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminal Domain HTH_18 PF12833.7 ACT00408.1 - 9.8e-21 73.8 0.2 1.9e-20 72.9 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00408.1 - 1.1e-13 50.9 0.0 8.5e-08 32.1 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT00408.1 - 8.8e-12 45.1 0.1 1.8e-11 44.1 0.1 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT00408.1 - 6.8e-05 22.5 0.0 0.00011 21.8 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding_2 PF14525.6 ACT00408.1 - 0.016 14.9 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 AraC-binding-like domain Glyco_hydro_42 PF02449.15 ACT00409.1 - 3.1e-154 513.8 3.6 4.7e-154 513.2 3.6 1.3 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_42M PF08532.10 ACT00409.1 - 2.4e-71 239.5 0.0 4.7e-71 238.6 0.0 1.5 1 0 0 1 1 1 1 Beta-galactosidase trimerisation domain Glyco_hydro_42C PF08533.10 ACT00409.1 - 6.5e-14 51.4 0.1 1.5e-13 50.2 0.1 1.6 1 0 0 1 1 1 1 Beta-galactosidase C-terminal domain Glyco_hydro_14 PF01373.17 ACT00409.1 - 5.2e-05 22.4 1.9 0.00013 21.0 0.1 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 14 DUF4434 PF14488.6 ACT00409.1 - 0.00051 20.1 0.4 0.0043 17.1 0.4 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4434) Glyco_hydro_2_C PF02836.17 ACT00409.1 - 0.00073 18.7 0.1 0.0033 16.6 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 ACT00409.1 - 0.0033 16.9 1.1 0.0058 16.1 1.1 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.19 ACT00409.1 - 0.022 14.4 0.2 0.063 12.9 0.2 1.9 1 1 0 1 1 1 0 Glycosyl hydrolases family 35 Malt_amylase_C PF16657.5 ACT00409.1 - 0.11 12.7 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Maltogenic Amylase, C-terminal domain HTH_18 PF12833.7 ACT00410.1 - 1.8e-20 73.0 0.0 5.1e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain dCache_1 PF02743.18 ACT00410.1 - 2.9e-15 56.7 1.2 2.9e-15 56.7 1.2 2.0 2 0 0 2 2 2 1 Cache domain HTH_AraC PF00165.23 ACT00410.1 - 1.1e-08 34.9 0.2 3.3e-05 23.9 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HAMP PF00672.25 ACT00410.1 - 0.00011 22.5 1.5 0.00024 21.4 0.2 2.4 2 0 0 2 2 2 1 HAMP domain TFIIE_alpha PF02002.17 ACT00410.1 - 0.0058 16.5 0.0 0.048 13.5 0.1 2.5 2 0 0 2 2 2 1 TFIIE alpha subunit Rrf2 PF02082.20 ACT00410.1 - 0.0067 16.8 0.0 0.04 14.3 0.0 2.4 2 0 0 2 2 2 1 Transcriptional regulator GGDEF_2 PF17853.1 ACT00410.1 - 0.1 12.9 0.0 0.54 10.5 0.0 2.3 2 0 0 2 2 2 0 GGDEF-like domain BPD_transp_1 PF00528.22 ACT00411.1 - 4.7e-18 65.6 7.2 4.7e-18 65.6 7.2 1.9 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00412.1 - 6.3e-16 58.7 14.1 1.9e-15 57.1 14.1 1.8 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Erg28 PF03694.13 ACT00412.1 - 0.015 15.7 0.7 0.047 14.1 0.7 1.8 1 0 0 1 1 1 0 Erg28 like protein DUF3502 PF12010.8 ACT00413.1 - 9.6e-05 23.0 3.2 0.00027 21.6 1.6 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) AbiTii PF18864.1 ACT00413.1 - 0.018 15.2 0.2 0.13 12.4 0.2 2.0 2 0 0 2 2 2 0 AbiTii Glyco_hydro_88 PF07470.13 ACT00414.1 - 9.5e-72 241.9 9.1 1.3e-71 241.5 9.1 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 ACT00414.1 - 0.0019 16.8 1.1 0.91 7.9 0.1 3.1 2 1 0 3 3 3 3 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_76 PF03663.14 ACT00414.1 - 0.0031 17.1 5.5 0.018 14.5 1.0 2.9 2 1 1 3 3 3 1 Glycosyl hydrolase family 76 Flavodoxin_2 PF02525.17 ACT00415.1 - 1.3e-34 119.7 0.1 1.4e-34 119.5 0.1 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ACT00415.1 - 6.3e-11 42.3 0.0 8.5e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase MarR PF01047.22 ACT00416.1 - 1.9e-06 27.7 0.0 7.6e-06 25.8 0.0 2.0 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 ACT00416.1 - 0.00048 20.6 0.0 0.0012 19.3 0.0 1.8 1 0 0 1 1 1 1 Winged helix DNA-binding domain HxlR PF01638.17 ACT00416.1 - 0.029 14.2 0.0 0.073 12.9 0.0 1.7 1 0 0 1 1 1 0 HxlR-like helix-turn-helix MarR_2 PF12802.7 ACT00416.1 - 0.056 13.3 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 MarR family TrmB PF01978.19 ACT00416.1 - 0.058 13.3 0.0 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Sigma70_r4 PF04545.16 ACT00416.1 - 0.1 12.1 0.4 0.58 9.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_18 PF12833.7 ACT00417.1 - 4.6e-18 65.3 0.1 1.1e-17 64.0 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00417.1 - 3.7e-09 36.4 0.2 0.0014 18.7 0.1 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_DeoR PF08220.12 ACT00417.1 - 0.034 13.9 0.1 0.073 12.8 0.1 1.5 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain Abhydrolase_1 PF00561.20 ACT00418.1 - 5.9e-21 75.3 0.0 7.1e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACT00418.1 - 7.2e-14 52.9 0.0 8.5e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACT00418.1 - 0.00011 21.6 0.0 0.00019 20.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 ACT00418.1 - 0.0013 18.3 0.0 0.002 17.8 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase DUF1057 PF06342.12 ACT00418.1 - 0.22 10.5 0.0 0.28 10.2 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) BPD_transp_1 PF00528.22 ACT00419.1 - 1.5e-12 47.6 11.7 1.5e-12 47.6 11.7 2.1 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component AA_permease_C PF13906.6 ACT00419.1 - 7.2 6.8 10.7 10 6.3 0.2 3.6 3 0 0 3 3 3 0 C-terminus of AA_permease BPD_transp_1 PF00528.22 ACT00420.1 - 1e-13 51.4 4.3 1e-13 51.4 4.3 2.4 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SUR7 PF06687.12 ACT00420.1 - 1.1 8.8 12.4 2.7 7.5 12.4 1.7 1 1 0 1 1 1 0 SUR7/PalI family SBP_bac_1 PF01547.25 ACT00421.1 - 1.2e-24 87.9 20.4 1.2e-24 87.9 20.4 1.9 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein Response_reg PF00072.24 ACT00422.1 - 2.8e-22 79.0 0.0 7.7e-22 77.6 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00422.1 - 1.6e-20 73.1 0.0 1.7e-19 69.9 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00422.1 - 1e-15 57.4 1.1 9.3e-09 35.2 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family His_kinase PF06580.13 ACT00423.1 - 4.1e-24 84.7 2.9 7.4e-24 83.9 0.5 2.6 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT00423.1 - 5.9e-14 52.4 5.3 5.9e-14 52.4 5.3 1.8 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACT00423.1 - 1.9e-08 34.8 0.0 3.7e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT00423.1 - 1.2e-05 25.6 0.5 3.4e-05 24.2 0.4 1.8 2 0 0 2 2 2 1 HAMP domain HATPase_c_3 PF13589.6 ACT00423.1 - 0.039 13.8 0.0 0.087 12.6 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UPF0242 PF06785.11 ACT00423.1 - 0.062 13.4 0.7 4.3 7.4 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SurA_N_3 PF13624.6 ACT00423.1 - 0.32 10.8 4.1 4.7 7.0 0.5 2.5 2 0 0 2 2 2 0 SurA N-terminal domain OapA_N PF08525.11 ACT00423.1 - 4.4 7.4 7.6 1.6 8.8 0.7 2.3 2 0 0 2 2 2 0 Opacity-associated protein A N-terminal motif Glyco_hydro_63 PF03200.16 ACT00424.1 - 7.3e-11 41.5 6.3 7.3e-11 41.5 6.3 2.1 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain Trehalase PF01204.18 ACT00424.1 - 1.2e-06 27.7 4.4 1.3e-06 27.6 2.0 1.9 2 0 0 2 2 2 1 Trehalase HTH_18 PF12833.7 ACT00425.1 - 6.9e-20 71.1 0.3 1.3e-19 70.2 0.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00425.1 - 2.1e-19 69.1 0.2 1.3e-09 37.9 0.1 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT00425.1 - 1.7e-07 30.8 0.9 3e-07 30.1 0.9 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACT00425.1 - 3.3e-06 27.1 2.7 5.4e-06 26.3 0.6 2.4 2 1 1 3 3 3 1 AraC-like ligand binding domain MannoseP_isomer PF01050.18 ACT00425.1 - 0.0086 16.0 0.2 0.014 15.3 0.2 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Ectoine_synth PF06339.12 ACT00425.1 - 0.12 12.6 0.7 0.22 11.7 0.7 1.4 1 0 0 1 1 1 0 Ectoine synthase TetR_N PF00440.23 ACT00426.1 - 2.7e-08 33.5 0.0 5.1e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_22 PF13309.6 ACT00426.1 - 0.0015 18.5 0.5 0.0072 16.4 0.1 2.4 3 0 0 3 3 3 1 HTH domain HTH_7 PF02796.15 ACT00426.1 - 0.0018 18.3 0.1 0.0037 17.3 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_Tnp_1_2 PF13022.6 ACT00426.1 - 0.0028 17.8 0.2 0.0098 16.0 0.0 2.0 1 1 1 2 2 2 1 Helix-turn-helix of insertion element transposase HTH_11 PF08279.12 ACT00426.1 - 0.036 14.0 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 HTH domain HTH_23 PF13384.6 ACT00426.1 - 0.11 12.3 0.1 0.33 10.8 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain Aldo_ket_red PF00248.21 ACT00427.1 - 1e-81 274.4 0.0 1.1e-81 274.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family WcbI PF18588.1 ACT00427.1 - 0.037 13.6 0.0 0.054 13.1 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis enzyme WcbI His_kinase PF06580.13 ACT00428.1 - 5.5e-24 84.3 0.2 1.7e-23 82.7 0.2 1.9 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT00428.1 - 6.2e-14 52.4 5.2 9.1e-14 51.8 5.2 1.3 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 ACT00428.1 - 5.2e-09 36.3 0.1 1.9e-08 34.6 0.0 2.0 2 0 0 2 2 2 1 HAMP domain HATPase_c PF02518.26 ACT00428.1 - 8.3e-06 26.3 0.3 2.1e-05 25.0 0.3 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cache_3-Cache_2 PF17201.4 ACT00428.1 - 0.0013 18.1 0.1 0.0025 17.1 0.1 1.4 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain HATPase_c_2 PF13581.6 ACT00428.1 - 0.0015 18.5 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain DUF4448 PF14610.6 ACT00428.1 - 0.064 13.0 0.0 0.34 10.7 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) LapA_dom PF06305.11 ACT00428.1 - 0.16 11.8 1.0 0.4 10.5 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Response_reg PF00072.24 ACT00429.1 - 6.6e-21 74.6 0.2 1.3e-20 73.6 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT00429.1 - 3e-18 65.4 0.0 1e-07 31.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT00429.1 - 5e-17 61.9 0.0 1.2e-15 57.6 0.0 2.9 3 0 0 3 3 3 1 Helix-turn-helix domain Rrf2 PF02082.20 ACT00429.1 - 0.036 14.4 0.0 0.23 11.8 0.0 2.3 2 0 0 2 2 2 0 Transcriptional regulator HTH_23 PF13384.6 ACT00429.1 - 0.12 12.3 0.0 35 4.4 0.0 3.6 3 0 0 3 3 3 0 Homeodomain-like domain SBP_bac_1 PF01547.25 ACT00430.1 - 5.6e-37 128.4 15.8 9.6e-37 127.6 15.8 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT00430.1 - 2.1e-07 30.6 1.9 0.0054 16.2 0.1 2.3 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT00430.1 - 1.1e-05 25.3 0.0 0.0064 16.3 0.1 2.3 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein DUF3558 PF12079.8 ACT00430.1 - 2.9 7.9 9.4 4.9 7.1 9.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) F5_F8_type_C PF00754.25 ACT00431.1 - 6e-10 39.3 10.9 2.5e-09 37.3 10.9 2.2 1 0 0 1 1 1 1 F5/8 type C domain Sad1_UNC PF07738.13 ACT00431.1 - 0.0041 17.1 0.1 0.012 15.7 0.1 1.7 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal BPD_transp_1 PF00528.22 ACT00432.1 - 9.2e-17 61.4 21.0 9.2e-17 61.4 21.0 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Deltameth_res PF16020.5 ACT00432.1 - 0.17 11.8 0.9 0.73 9.8 0.9 2.1 1 0 0 1 1 1 0 Deltamethrin resistance BPD_transp_1 PF00528.22 ACT00433.1 - 3.3e-12 46.5 22.2 1.1e-11 44.8 19.9 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Alpha_L_fucos PF01120.17 ACT00434.1 - 1.4e-40 139.8 0.0 1e-39 137.0 0.0 2.1 1 1 0 1 1 1 1 Alpha-L-fucosidase F5_F8_type_C PF00754.25 ACT00434.1 - 1.7e-08 34.6 0.1 3.6e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 F5/8 type C domain GHL6 PF14871.6 ACT00434.1 - 0.00039 20.6 0.0 0.0023 18.1 0.0 2.2 2 0 0 2 2 2 1 Hypothetical glycosyl hydrolase 6 DR2241 PF18069.1 ACT00434.1 - 0.082 12.8 0.3 0.17 11.8 0.3 1.5 1 0 0 1 1 1 0 DR2241 stabilising domain QH-AmDH_gamma PF08992.11 ACT00434.1 - 0.11 12.5 0.7 0.28 11.2 0.2 1.9 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, gamma subunit DUF4434 PF14488.6 ACT00434.1 - 0.14 12.2 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) Rotamase_2 PF13145.6 ACT00435.1 - 1.6e-08 35.4 3.0 3.2e-07 31.2 0.1 2.7 2 1 1 3 3 3 1 PPIC-type PPIASE domain Rotamase PF00639.21 ACT00435.1 - 4.4e-07 30.8 0.4 1.7e-06 28.9 0.0 2.1 2 0 0 2 2 2 1 PPIC-type PPIASE domain SurA_N_3 PF13624.6 ACT00435.1 - 0.00011 22.0 3.7 0.0012 18.7 0.0 3.5 4 0 0 4 4 4 1 SurA N-terminal domain SurA_N_2 PF13623.6 ACT00435.1 - 0.0012 18.7 2.5 0.052 13.4 0.0 3.5 3 1 0 3 3 3 1 SurA N-terminal domain Rotamase_3 PF13616.6 ACT00435.1 - 0.0054 17.3 0.5 0.02 15.4 0.0 2.1 2 1 0 2 2 2 1 PPIC-type PPIASE domain HTH_18 PF12833.7 ACT00436.1 - 4.4e-20 71.7 0.0 9.5e-20 70.7 0.0 1.6 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00436.1 - 1.9e-12 46.9 0.6 2.1e-05 24.5 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT00436.1 - 5.8e-09 35.5 0.5 1e-08 34.7 0.5 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACT00436.1 - 7.2e-09 35.7 2.2 6.9e-08 32.5 1.2 2.7 2 1 1 3 3 3 1 AraC-like ligand binding domain ARD PF03079.14 ACT00436.1 - 2.6e-06 27.7 0.1 7.8e-06 26.1 0.1 1.8 1 0 0 1 1 1 1 ARD/ARD' family Cupin_1 PF00190.22 ACT00436.1 - 0.019 14.6 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Cupin EutQ PF06249.12 ACT00436.1 - 0.029 14.1 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutQ CTP-dep_RFKase PF01982.16 ACT00436.1 - 0.066 13.3 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF120 Cupin_3 PF05899.12 ACT00436.1 - 0.11 12.2 0.0 0.44 10.3 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF861) Glyco_hydro_43 PF04616.14 ACT00437.1 - 1.4e-51 175.5 5.2 1.6e-51 175.3 5.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 SBP_bac_8 PF13416.6 ACT00438.1 - 5.9e-18 65.7 14.2 1.1e-17 64.8 14.2 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT00438.1 - 0.0013 18.5 0.3 0.014 15.2 0.1 2.3 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT00438.1 - 0.0021 18.7 0.0 0.0021 18.7 0.0 2.9 4 1 0 4 4 4 1 Domain of unknown function (DUF3502) BPD_transp_1 PF00528.22 ACT00439.1 - 4.2e-16 59.2 6.5 4.2e-16 59.2 6.5 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00440.1 - 9.3e-14 51.6 15.7 9.3e-14 51.6 15.7 2.1 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Holin_SPP1 PF04688.13 ACT00440.1 - 0.18 12.0 1.9 0.39 10.9 0.4 2.3 2 0 0 2 2 2 0 SPP1 phage holin MPS-4 PF17523.2 ACT00440.1 - 1 9.5 6.6 0.57 10.3 0.4 2.9 3 0 0 3 3 3 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 Glyco_hydro_2_N PF02837.18 ACT00441.1 - 5.5e-20 71.9 0.1 1.8e-19 70.3 0.1 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 ACT00441.1 - 6.3e-10 39.7 0.0 1.3e-09 38.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_C PF02836.17 ACT00441.1 - 4.2e-08 32.7 0.0 1e-07 31.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain BetaGal_dom4_5 PF13364.6 ACT00441.1 - 0.0022 18.6 0.0 0.0052 17.3 0.0 1.6 1 0 0 1 1 1 1 Beta-galactosidase jelly roll domain GxGYxYP_C PF14323.6 ACT00443.1 - 1.9e-67 227.6 1.0 4.1e-67 226.6 1.0 1.6 1 0 0 1 1 1 1 GxGYxYP putative glycoside hydrolase C-terminal domain GxGYxYP_N PF16216.5 ACT00443.1 - 5.3e-58 196.7 0.5 9.1e-34 117.5 0.0 2.3 2 0 0 2 2 2 2 GxGYxY sequence motif in domain of unknown function N-terminal MarR_2 PF12802.7 ACT00444.1 - 0.00037 20.3 0.5 0.00082 19.2 0.5 1.5 1 0 0 1 1 1 1 MarR family DUF1403 PF07183.11 ACT00444.1 - 0.05 13.2 1.6 0.065 12.8 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1403) Rrf2 PF02082.20 ACT00444.1 - 0.057 13.8 0.0 0.097 13.0 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator Cu_amine_oxidN1 PF07833.11 ACT00445.1 - 5.4e-26 90.9 0.3 4.9e-18 65.4 0.0 2.1 1 1 1 2 2 2 2 Copper amine oxidase N-terminal domain Hydrolase_2 PF07486.12 ACT00445.1 - 1.2e-24 87.1 0.0 1.9e-24 86.5 0.0 1.3 1 0 0 1 1 1 1 Cell Wall Hydrolase LysM PF01476.20 ACT00445.1 - 1e-05 25.5 0.0 2.4e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 LysM domain TetR_N PF00440.23 ACT00446.1 - 8.5e-05 22.3 0.0 0.0002 21.1 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family APH PF01636.23 ACT00447.1 - 5.2e-17 62.6 0.2 1.4e-16 61.2 0.2 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ACT00447.1 - 0.003 16.9 0.1 0.0046 16.3 0.1 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 ACT00447.1 - 0.023 14.3 0.0 0.045 13.3 0.0 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 ACT00447.1 - 0.029 14.0 0.0 0.094 12.3 0.0 1.8 2 0 0 2 2 2 0 RIO1 family FAD_binding_1 PF00667.20 ACT00448.1 - 4.5e-34 118.0 0.0 7.9e-34 117.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ACT00448.1 - 1.8e-30 106.0 0.1 3.5e-30 105.1 0.1 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ACT00448.1 - 3.5e-18 66.2 0.0 9.3e-18 64.9 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 ACT00448.1 - 0.0007 19.9 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin domain PAC4 PF16093.5 ACT00448.1 - 0.12 12.6 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 Flavodoxin_3 PF12641.7 ACT00448.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin domain NIR_SIR PF01077.22 ACT00449.1 - 1.3e-53 180.8 0.0 6.6e-46 155.7 0.0 2.3 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 ACT00449.1 - 9.5e-31 105.5 0.1 5.1e-15 55.1 0.0 3.2 3 0 0 3 3 3 2 Nitrite/Sulfite reductase ferredoxin-like half domain ROK PF00480.20 ACT00450.1 - 6.4e-55 186.7 0.0 8e-55 186.4 0.0 1.1 1 0 0 1 1 1 1 ROK family HTH_24 PF13412.6 ACT00450.1 - 0.0043 16.6 0.3 0.0095 15.5 0.2 1.7 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Lar_N PF09861.9 ACT00451.1 - 6.6e-10 38.5 0.7 1.3e-09 37.5 0.1 1.7 2 0 0 2 2 2 1 Lactate racemase N-terminal domain DUF362 PF04015.12 ACT00451.1 - 0.00012 22.4 0.1 0.00034 20.9 0.0 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF362) adh_short_C2 PF13561.6 ACT00452.1 - 1.5e-53 181.7 0.0 1.9e-53 181.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT00452.1 - 5.2e-45 153.3 0.1 6.1e-45 153.1 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT00452.1 - 1.5e-09 38.0 0.1 2e-09 37.6 0.1 1.1 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 ACT00452.1 - 0.0014 18.0 0.2 0.0014 18.0 0.2 1.6 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 ACT00452.1 - 0.0029 17.7 0.1 0.0061 16.6 0.1 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 ACT00452.1 - 0.0064 16.7 0.0 0.0098 16.2 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 ACT00452.1 - 0.0075 16.7 0.0 0.024 15.1 0.0 1.8 2 0 0 2 2 2 1 Putative NAD(P)-binding Glyco_trans_4_4 PF13579.6 ACT00452.1 - 0.049 14.1 0.1 5.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain ApbA PF02558.16 ACT00452.1 - 0.05 13.2 0.0 0.18 11.5 0.1 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 ACT00452.1 - 0.073 13.2 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Epimerase PF01370.21 ACT00452.1 - 0.099 12.1 0.1 0.44 10.0 0.1 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 ACT00452.1 - 0.1 12.5 0.4 0.22 11.4 0.3 1.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_transf_4 PF13439.6 ACT00452.1 - 0.18 11.8 0.0 8.8 6.3 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.11 ACT00452.1 - 0.19 11.4 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 Starch synthase catalytic domain NAD_synthase PF02540.17 ACT00453.1 - 1e-08 34.6 0.1 1.3e-07 31.0 0.0 2.1 2 0 0 2 2 2 1 NAD synthase QueC PF06508.13 ACT00453.1 - 2.4e-06 27.2 0.1 7.3e-06 25.6 0.0 1.8 2 1 0 2 2 2 1 Queuosine biosynthesis protein QueC ATP_bind_3 PF01171.20 ACT00453.1 - 2.1e-05 24.4 0.0 4.5e-05 23.3 0.0 1.6 2 0 0 2 2 2 1 PP-loop family Asn_synthase PF00733.21 ACT00453.1 - 0.00017 21.4 0.1 0.00027 20.7 0.1 1.2 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.16 ACT00453.1 - 0.0019 17.1 0.1 0.011 14.6 0.1 1.9 2 0 0 2 2 2 1 tRNA methyl transferase Arginosuc_synth PF00764.19 ACT00453.1 - 0.02 14.2 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 Arginosuccinate synthase FGGY_N PF00370.21 ACT00454.1 - 6e-60 202.8 0.0 7.8e-60 202.5 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ACT00454.1 - 2e-36 125.6 0.1 3.1e-36 125.0 0.1 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 ACT00454.1 - 0.00031 20.3 0.0 0.0012 18.4 0.0 2.1 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family AIRC PF00731.20 ACT00455.1 - 3.3e-14 52.7 3.1 3.3e-14 52.7 3.1 1.6 2 0 0 2 2 2 1 AIR carboxylase DUF1018 PF06252.12 ACT00455.1 - 0.1 13.6 0.0 0.16 12.9 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1018) DsbD_2 PF13386.6 ACT00456.1 - 3.2e-06 27.2 16.9 3.7e-05 23.8 16.9 2.1 1 1 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region NicO PF03824.16 ACT00456.1 - 0.00011 21.7 1.2 0.00011 21.7 1.2 2.2 1 1 0 2 2 2 1 High-affinity nickel-transport protein OFeT_1 PF16955.5 ACT00456.1 - 0.001 18.8 3.3 0.0015 18.3 3.2 1.5 1 1 0 1 1 1 1 Ferrous iron uptake permease, iron-lead transporter DUF2053 PF09767.9 ACT00456.1 - 0.0085 16.3 0.9 0.0085 16.3 0.9 2.0 2 1 0 2 2 2 1 Predicted membrane protein (DUF2053) DUF3930 PF13067.6 ACT00456.1 - 0.88 9.9 4.2 0.44 10.8 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3930) Glyco_hydro_18 PF00704.28 ACT00457.1 - 2.9e-81 273.6 5.0 5e-81 272.8 5.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 SLH PF00395.20 ACT00457.1 - 7.7e-22 77.0 0.8 7.8e-10 38.6 0.5 4.2 4 0 0 4 4 4 3 S-layer homology domain fn3 PF00041.21 ACT00457.1 - 3.4e-16 59.4 9.1 5.3e-06 26.7 0.0 6.1 4 2 0 4 4 4 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 ACT00457.1 - 0.00015 22.2 12.1 0.15 12.7 2.5 5.3 3 2 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Arylsulfotran_N PF17425.2 ACT00457.1 - 0.00037 20.5 0.1 0.17 11.9 0.1 3.3 2 0 0 2 2 2 1 Arylsulfotransferase Ig-like domain DUF2369 PF10179.9 ACT00457.1 - 0.048 14.0 0.0 6.2 7.3 0.0 3.2 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2369) ABC_tran PF00005.27 ACT00458.1 - 3.1e-31 108.7 0.1 1.3e-30 106.7 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ACT00458.1 - 2.3e-14 53.9 0.1 1.5e-09 38.1 0.0 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 ACT00458.1 - 1.1e-07 32.4 0.1 2.5e-07 31.3 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_22 PF13401.6 ACT00458.1 - 0.00013 22.2 0.2 0.0011 19.2 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ACT00458.1 - 0.00062 20.2 0.8 0.0015 19.0 0.3 1.8 1 1 1 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 ACT00458.1 - 0.0012 18.6 0.0 0.99 9.0 0.0 2.3 1 1 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 ACT00458.1 - 0.0032 17.6 0.2 0.013 15.6 0.2 2.0 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.22 ACT00458.1 - 0.0045 16.7 0.0 0.0088 15.7 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain DUF4912 PF16258.5 ACT00458.1 - 0.0067 16.6 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4912) AAA PF00004.29 ACT00458.1 - 0.013 15.9 0.2 0.13 12.7 0.2 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ACT00458.1 - 0.014 15.9 0.4 0.04 14.4 0.3 1.8 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.6 ACT00458.1 - 0.02 14.6 0.1 0.043 13.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 ACT00458.1 - 0.03 14.0 0.1 0.15 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 ACT00458.1 - 0.042 13.3 0.0 1.1 8.6 0.0 2.3 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ACT00458.1 - 0.048 13.9 0.0 0.26 11.6 0.0 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_27 PF13514.6 ACT00458.1 - 0.064 12.8 0.1 0.49 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ACT00458.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ABC2_membrane PF01061.24 ACT00459.1 - 2.4e-33 115.3 15.7 2.4e-33 115.3 15.7 1.7 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ACT00459.1 - 2e-13 50.2 16.1 3.3e-13 49.5 16.1 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein FAD_binding_3 PF01494.19 ACT00460.1 - 3.9e-22 79.0 2.0 6.1e-21 75.0 2.0 2.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ACT00460.1 - 1.9e-06 27.3 0.2 5.8e-06 25.8 0.2 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT00460.1 - 5.9e-06 26.1 1.3 0.00016 21.4 0.9 2.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ACT00460.1 - 4.3e-05 22.7 0.2 0.0088 15.1 0.6 2.9 2 1 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 ACT00460.1 - 8.1e-05 22.8 0.3 0.00026 21.2 0.3 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 ACT00460.1 - 0.00046 19.3 0.0 0.041 12.9 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox_3 PF13738.6 ACT00460.1 - 0.00098 18.5 0.4 0.0078 15.5 0.4 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ACT00460.1 - 0.0072 15.1 0.2 0.023 13.4 0.2 1.9 1 1 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 ACT00460.1 - 0.015 14.6 0.1 0.023 13.9 0.1 1.3 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 ACT00460.1 - 0.024 13.8 0.5 0.056 12.5 0.5 1.6 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 ACT00460.1 - 0.028 13.3 0.1 5.8 5.7 0.0 2.7 3 0 0 3 3 3 0 Tryptophan halogenase Pyr_redox PF00070.27 ACT00460.1 - 0.028 15.0 0.1 0.081 13.5 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ACT00460.1 - 0.22 11.5 0.6 6.6 6.7 0.3 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding HTH_18 PF12833.7 ACT00461.1 - 4.7e-21 74.8 0.6 1.6e-20 73.1 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00461.1 - 1.2e-20 73.0 0.2 2.8e-09 36.8 0.1 3.3 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family dCache_1 PF02743.18 ACT00461.1 - 9.2e-18 64.9 2.5 9.2e-18 64.9 2.5 2.0 2 0 0 2 2 2 1 Cache domain GGDEF_2 PF17853.1 ACT00461.1 - 4e-09 36.7 0.0 9.2e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 GGDEF-like domain DUF948 PF06103.11 ACT00461.1 - 0.2 11.9 1.3 8.3 6.7 0.1 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) dCache_2 PF08269.11 ACT00461.1 - 0.23 10.6 6.3 11 5.1 0.0 3.6 3 2 0 3 3 3 0 Cache domain Glutaredoxin2_C PF04399.13 ACT00461.1 - 0.27 11.1 3.1 11 5.9 0.2 2.9 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain Toxin_trans PF07952.12 ACT00461.1 - 0.61 9.1 6.8 1.6 7.7 0.2 3.4 3 1 1 4 4 4 0 Clostridium neurotoxin, Translocation domain Lipoprotein_6 PF01441.19 ACT00461.1 - 1.1 9.2 3.6 4.7 7.2 0.5 2.8 2 1 0 2 2 2 0 Lipoprotein DUF4446 PF14584.6 ACT00461.1 - 6 6.8 6.4 1.9 8.5 0.4 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF4446) SBP_bac_1 PF01547.25 ACT00462.1 - 2.9e-07 30.7 0.6 4.7e-07 30.1 0.6 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT00463.1 - 4.3e-13 49.9 14.2 4.3e-13 49.9 14.2 1.5 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT00463.1 - 0.0083 16.8 2.0 0.0083 16.8 2.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3502) DUF4969 PF16339.5 ACT00463.1 - 0.017 15.5 0.1 0.038 14.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4969) BPD_transp_1 PF00528.22 ACT00464.1 - 2.8e-18 66.3 10.0 2.8e-18 66.3 10.0 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00465.1 - 3.7e-21 75.7 8.4 3.7e-21 75.7 8.4 2.1 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2207 PF09972.9 ACT00465.1 - 2.7 6.6 5.0 2.1 7.0 3.3 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) HxlR PF01638.17 ACT00467.1 - 4.3e-28 97.0 0.1 5.5e-28 96.6 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix MarR PF01047.22 ACT00467.1 - 0.0042 17.0 0.0 0.0063 16.4 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_45 PF14947.6 ACT00467.1 - 0.007 16.3 0.0 0.012 15.6 0.0 1.5 1 1 0 1 1 1 1 Winged helix-turn-helix MarR_2 PF12802.7 ACT00467.1 - 0.0096 15.8 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 MarR family DUF2513 PF10711.9 ACT00467.1 - 0.03 14.6 0.0 0.042 14.1 0.0 1.2 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) DUF3116 PF11313.8 ACT00467.1 - 0.041 13.7 0.0 0.051 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3116) LIP PF03583.14 ACT00467.1 - 0.11 11.8 0.0 0.12 11.7 0.0 1.0 1 0 0 1 1 1 0 Secretory lipase HTH_34 PF13601.6 ACT00467.1 - 0.13 12.4 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain Replic_Relax PF13814.6 ACT00467.1 - 0.14 12.2 0.0 0.18 11.9 0.0 1.1 1 0 0 1 1 1 0 Replication-relaxation MFS_1 PF07690.16 ACT00468.1 - 9.1e-36 123.5 60.6 1.7e-24 86.4 35.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT00468.1 - 4.1e-06 25.9 41.1 0.00037 19.5 22.5 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter HTH_18 PF12833.7 ACT00469.1 - 1.7e-19 69.8 0.1 3.6e-19 68.8 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00469.1 - 6.6e-15 54.8 0.1 1.8e-06 27.8 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family FANCI_HD2 PF14680.6 ACT00469.1 - 0.0094 15.2 0.4 0.023 14.0 0.1 1.7 1 1 1 2 2 2 1 FANCI helical domain 2 AraC_binding PF02311.19 ACT00469.1 - 0.061 13.2 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT00469.1 - 0.12 12.1 0.1 0.25 11.1 0.1 1.4 1 0 0 1 1 1 0 Cupin domain BPD_transp_1 PF00528.22 ACT00470.1 - 2.8e-18 66.3 11.7 2.8e-18 66.3 11.7 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component LIM_bind PF01803.16 ACT00470.1 - 0.0091 15.5 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 LIM-domain binding protein BPD_transp_1 PF00528.22 ACT00471.1 - 1.7e-09 37.7 21.8 1.6e-08 34.5 21.8 2.2 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF3558 PF12079.8 ACT00472.1 - 0.36 10.8 2.1 0.78 9.7 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) ABC_tran PF00005.27 ACT00473.1 - 4.4e-29 101.7 0.0 6.6e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00473.1 - 4e-11 43.3 0.0 0.00013 21.9 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT00473.1 - 1.4e-09 37.7 0.0 4.1e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ACT00473.1 - 1.2e-05 25.2 0.2 0.00023 21.0 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ACT00473.1 - 7.2e-05 22.4 0.0 0.00019 21.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 ACT00473.1 - 8.8e-05 22.7 0.0 0.0002 21.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT00473.1 - 0.00021 21.2 0.0 0.00049 20.0 0.0 1.7 2 0 0 2 2 1 1 RsgA GTPase AAA_23 PF13476.6 ACT00473.1 - 0.00024 21.7 0.2 0.0009 19.8 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ACT00473.1 - 0.00066 20.0 0.2 0.0035 17.6 0.2 2.2 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 ACT00473.1 - 0.0008 19.4 0.0 0.0018 18.2 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 ACT00473.1 - 0.00095 19.6 0.1 0.0033 17.8 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 ACT00473.1 - 0.0016 18.0 0.0 0.038 13.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 ACT00473.1 - 0.0049 16.1 0.0 0.0099 15.1 0.0 1.4 1 1 0 1 1 1 1 G-protein alpha subunit IstB_IS21 PF01695.17 ACT00473.1 - 0.0064 16.2 0.1 1.4 8.6 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_30 PF13604.6 ACT00473.1 - 0.0069 16.1 0.0 0.37 10.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ACT00473.1 - 0.011 16.3 0.0 0.036 14.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ACT00473.1 - 0.014 14.6 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 ACT00473.1 - 0.039 13.9 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA PF00004.29 ACT00473.1 - 0.047 14.1 0.3 0.54 10.7 0.3 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Adeno_IVa2 PF02456.15 ACT00473.1 - 0.052 12.3 0.0 0.28 9.9 0.0 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein RNA_helicase PF00910.22 ACT00473.1 - 0.064 13.7 0.1 0.27 11.6 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 ACT00473.1 - 0.07 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ACT00473.1 - 0.083 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 ACT00473.1 - 0.098 12.4 0.1 0.34 10.6 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.14 ACT00473.1 - 0.13 12.2 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) BPD_transp_1 PF00528.22 ACT00474.1 - 2.2e-36 125.3 9.2 2.2e-36 125.3 9.2 2.2 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component TssN PF17555.2 ACT00474.1 - 0.059 12.7 8.4 0.042 13.2 2.1 2.2 2 0 0 2 2 2 0 Type VI secretion system, TssN BPD_transp_1 PF00528.22 ACT00475.1 - 1.8e-25 89.7 30.6 1e-24 87.3 21.7 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component PBP_like_2 PF12849.7 ACT00476.1 - 3.9e-39 135.0 11.5 1.3e-38 133.3 11.5 1.7 1 1 0 1 1 1 1 PBP superfamily domain PBP_like PF12727.7 ACT00476.1 - 4.2e-29 101.0 0.4 5.5e-29 100.7 0.4 1.1 1 0 0 1 1 1 1 PBP superfamily domain SBP_bac_11 PF13531.6 ACT00476.1 - 1.5e-10 41.2 2.0 2.4e-10 40.5 2.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Peptidase_M20 PF01546.28 ACT00477.1 - 6.2e-31 107.7 0.0 1.1e-30 106.9 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ACT00477.1 - 1.2e-23 83.1 0.0 2.4e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ACT00477.1 - 0.011 15.4 0.1 0.018 14.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase family M28 DinB PF05163.12 ACT00478.1 - 4.4e-17 62.5 0.0 5.4e-17 62.2 0.0 1.0 1 0 0 1 1 1 1 DinB family DinB_2 PF12867.7 ACT00478.1 - 4e-12 46.8 0.1 4.5e-12 46.6 0.1 1.0 1 0 0 1 1 1 1 DinB superfamily DUF664 PF04978.12 ACT00478.1 - 0.00044 20.7 0.1 0.05 14.0 0.0 2.2 1 1 0 2 2 2 2 Protein of unknown function (DUF664) MDMPI_N PF11716.8 ACT00478.1 - 0.022 15.4 0.1 0.047 14.4 0.1 1.6 1 1 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain P16-Arc PF04699.14 ACT00479.1 - 0.093 13.2 0.0 23 5.5 0.0 2.3 2 0 0 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) TetR_C_1 PF02909.17 ACT00481.1 - 7.2e-12 45.3 0.0 1.6e-11 44.2 0.0 1.6 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 ACT00481.1 - 5.1e-10 39.0 0.1 8e-10 38.4 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family DUF4536 PF15055.6 ACT00481.1 - 0.082 13.2 0.1 0.31 11.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) ABC2_membrane PF01061.24 ACT00482.1 - 5.7e-26 91.2 16.0 5.7e-26 91.2 16.0 1.7 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ACT00482.1 - 2.8e-15 56.3 15.1 2.8e-15 56.3 15.1 1.9 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 ACT00482.1 - 0.85 8.8 24.1 0.049 12.9 14.9 2.2 1 1 1 2 2 2 0 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 ACT00482.1 - 5.4 6.9 14.4 1.7 8.6 10.0 2.2 1 1 2 3 3 3 0 ABC-2 family transporter protein ABC_tran PF00005.27 ACT00483.1 - 6.8e-28 97.9 0.0 1.1e-27 97.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00483.1 - 1.1e-12 48.3 1.9 3.1e-07 30.5 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT00483.1 - 6.8e-05 22.4 0.1 0.0024 17.3 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACT00483.1 - 6.9e-05 23.3 0.2 0.00011 22.7 0.2 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ACT00483.1 - 9.8e-05 22.4 0.1 0.00056 19.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 ACT00483.1 - 0.00044 20.0 0.5 0.019 14.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ACT00483.1 - 0.00063 19.4 0.3 0.0014 18.4 0.3 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACT00483.1 - 0.0011 19.5 0.5 0.0025 18.3 0.1 1.7 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 ACT00483.1 - 0.0033 17.5 0.0 0.0053 16.8 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_15 PF13175.6 ACT00483.1 - 0.0086 15.8 0.0 0.19 11.4 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain SRP54 PF00448.22 ACT00483.1 - 0.0095 15.6 0.4 0.028 14.1 0.1 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 ACT00483.1 - 0.011 15.4 0.3 0.024 14.2 0.3 1.7 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 ACT00483.1 - 0.016 14.8 0.2 0.09 12.4 0.1 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF4162 PF13732.6 ACT00483.1 - 0.02 15.6 0.0 0.11 13.2 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4162) Mg_chelatase PF01078.21 ACT00483.1 - 0.038 13.4 0.2 0.15 11.5 0.0 2.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Peptidase_M60 PF13402.6 ACT00483.1 - 0.039 13.5 0.0 0.11 12.0 0.0 1.6 2 0 0 2 2 2 0 Peptidase M60, enhancin and enhancin-like AAA_18 PF13238.6 ACT00483.1 - 0.055 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ACT00483.1 - 0.086 12.7 0.2 0.56 10.1 0.1 2.3 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 ACT00483.1 - 0.09 12.8 0.0 14 5.7 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 ACT00483.1 - 0.15 12.5 0.5 0.71 10.3 0.4 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) YtxH PF12732.7 ACT00484.1 - 1e-18 67.6 5.5 1.2e-17 64.2 5.5 2.0 1 1 0 1 1 1 1 YtxH-like protein DUF1043 PF06295.12 ACT00484.1 - 0.00096 19.1 0.1 0.0011 18.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) DUF883 PF05957.13 ACT00484.1 - 0.0011 19.5 4.6 0.0011 19.5 4.6 2.3 2 1 0 2 2 2 1 Bacterial protein of unknown function (DUF883) ApoLp-III PF07464.11 ACT00484.1 - 0.0012 18.9 2.7 0.0014 18.7 2.7 1.1 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) ApoC-I PF04691.12 ACT00484.1 - 0.0019 18.0 2.5 0.007 16.3 2.5 2.0 1 1 0 1 1 1 1 Apolipoprotein C-I (ApoC-1) Apolipoprotein PF01442.18 ACT00484.1 - 0.0077 16.1 2.2 0.0092 15.9 2.2 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Gp-FAR-1 PF05823.12 ACT00484.1 - 0.022 15.1 1.2 0.028 14.8 1.2 1.0 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Phasin PF05597.11 ACT00484.1 - 0.028 14.4 0.7 0.034 14.2 0.7 1.2 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Tim17 PF02466.19 ACT00484.1 - 0.036 14.4 0.1 0.039 14.3 0.1 1.3 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family ApoO PF09769.9 ACT00484.1 - 0.043 13.8 1.5 0.19 11.7 0.4 2.0 1 1 1 2 2 2 0 Apolipoprotein O Romo1 PF10247.9 ACT00484.1 - 0.058 13.8 0.0 0.078 13.4 0.0 1.2 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Grg1 PF11034.8 ACT00484.1 - 0.16 12.2 6.1 1.2 9.4 6.1 2.1 1 1 0 1 1 1 0 Glucose-repressible protein Grg1 YojJ PF10372.9 ACT00484.1 - 0.23 11.6 0.8 8.9 6.5 0.2 2.1 1 1 1 2 2 2 0 Bacterial membrane-spanning protein N-terminus DUF2232 PF09991.9 ACT00484.1 - 0.24 10.5 0.0 0.29 10.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Sigma70_r4 PF04545.16 ACT00485.1 - 7.3e-17 60.6 3.1 8.5e-16 57.2 1.5 2.6 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r3 PF04539.16 ACT00485.1 - 4.1e-14 52.4 0.1 4e-12 46.0 0.2 2.5 2 0 0 2 2 2 1 Sigma-70 region 3 Sigma70_r4_2 PF08281.12 ACT00485.1 - 3.7e-12 45.7 6.4 3.8e-11 42.5 0.6 3.4 4 0 0 4 4 4 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACT00485.1 - 5.7e-10 38.8 0.0 1.4e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 Sigma-70 region 2 HTH_23 PF13384.6 ACT00485.1 - 7.7e-08 31.9 0.2 1.5e-06 27.8 0.1 2.8 3 0 0 3 3 3 1 Homeodomain-like domain HTH_38 PF13936.6 ACT00485.1 - 6.4e-07 29.0 0.0 1e-05 25.2 0.0 2.8 3 0 0 3 3 3 1 Helix-turn-helix domain GerE PF00196.19 ACT00485.1 - 3.9e-06 26.3 0.2 7.1e-05 22.3 0.1 2.5 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family Sigma70_ECF PF07638.11 ACT00485.1 - 6.4e-06 26.2 5.3 0.0046 16.9 0.2 3.0 2 1 1 3 3 3 2 ECF sigma factor KORA PF16509.5 ACT00485.1 - 2.9e-05 24.3 0.1 7.2e-05 23.0 0.1 1.6 1 0 0 1 1 1 1 TrfB plasmid transcriptional repressor HTH_Crp_2 PF13545.6 ACT00485.1 - 3.6e-05 23.7 0.5 0.22 11.5 0.0 3.1 3 0 0 3 3 3 2 Crp-like helix-turn-helix domain Phage_antitermQ PF06530.12 ACT00485.1 - 0.00026 20.9 1.5 0.0034 17.3 0.2 2.9 3 0 0 3 3 3 1 Phage antitermination protein Q HTH_50 PF18024.1 ACT00485.1 - 0.00077 19.0 0.1 0.0048 16.5 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 ACT00485.1 - 0.0012 18.7 0.1 0.021 14.7 0.0 2.6 2 0 0 2 2 2 1 MarR family MarR PF01047.22 ACT00485.1 - 0.0013 18.6 0.0 0.0071 16.3 0.0 2.3 2 0 0 2 2 1 1 MarR family HTH_10 PF04967.12 ACT00485.1 - 0.0018 18.1 0.2 0.24 11.2 0.0 2.9 2 1 0 2 2 2 1 HTH DNA binding domain HTH_24 PF13412.6 ACT00485.1 - 0.004 16.7 0.0 0.016 14.7 0.0 2.1 2 0 0 2 2 1 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 ACT00485.1 - 0.0042 17.2 0.0 0.21 11.8 0.0 2.6 3 0 0 3 3 2 1 Helix-turn-helix domain Death PF00531.22 ACT00485.1 - 0.0044 17.2 1.1 3 8.1 0.1 3.4 2 2 1 3 3 3 1 Death domain HTH_6 PF01418.17 ACT00485.1 - 0.0085 16.0 1.0 0.17 11.9 0.1 3.0 3 1 0 3 3 2 1 Helix-turn-helix domain, rpiR family Crp PF00325.20 ACT00485.1 - 0.01 15.5 2.3 2.8 7.7 0.1 3.2 3 0 0 3 3 3 0 Bacterial regulatory proteins, crp family Talin_middle PF09141.10 ACT00485.1 - 0.012 15.7 0.1 0.03 14.4 0.1 1.7 1 0 0 1 1 1 0 Talin, middle domain Terminase_5 PF06056.12 ACT00485.1 - 0.016 15.0 0.0 1.3 8.9 0.0 2.5 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) HTH_29 PF13551.6 ACT00485.1 - 0.018 15.1 0.0 0.076 13.0 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn helix TnsD PF15978.5 ACT00485.1 - 0.022 13.8 1.9 0.45 9.4 0.1 2.6 2 1 0 3 3 3 0 Tn7-like transposition protein D HTH_Tnp_ISL3 PF13542.6 ACT00485.1 - 0.04 13.3 0.0 0.34 10.3 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 YdaS_antitoxin PF15943.5 ACT00485.1 - 0.053 13.4 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT RhoGAP PF00620.27 ACT00485.1 - 0.056 13.3 0.3 0.63 9.9 0.2 2.7 1 1 1 2 2 2 0 RhoGAP domain HTH_3 PF01381.22 ACT00485.1 - 0.056 13.5 1.5 0.31 11.1 0.1 2.5 3 0 0 3 3 2 0 Helix-turn-helix HTH_11 PF08279.12 ACT00485.1 - 0.063 13.2 0.2 0.51 10.3 0.0 2.6 2 1 0 2 2 2 0 HTH domain Trp_repressor PF01371.19 ACT00485.1 - 0.08 13.1 0.0 0.26 11.5 0.0 1.9 1 0 0 1 1 1 0 Trp repressor protein DUF1492 PF07374.11 ACT00485.1 - 0.088 13.0 0.1 0.21 11.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) HTH_31 PF13560.6 ACT00485.1 - 0.094 13.1 0.7 0.39 11.1 0.2 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_AsnC-type PF13404.6 ACT00485.1 - 0.1 12.4 0.5 1.5 8.7 0.0 2.7 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain HTH_7 PF02796.15 ACT00485.1 - 0.12 12.4 0.0 0.5 10.5 0.0 2.1 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_36 PF13730.6 ACT00485.1 - 0.13 12.3 0.0 12 5.9 0.0 3.1 2 1 0 2 2 2 0 Helix-turn-helix domain LacI PF00356.21 ACT00485.1 - 0.15 11.9 0.0 0.7 9.7 0.0 2.1 2 0 0 2 2 1 0 Bacterial regulatory proteins, lacI family UPF0122 PF04297.14 ACT00485.1 - 0.18 12.0 2.0 0.51 10.6 0.1 2.5 2 1 1 3 3 3 0 Putative helix-turn-helix protein, YlxM / p13 like HATPase_c_2 PF13581.6 ACT00486.1 - 4e-25 88.2 0.0 4.6e-25 88.0 0.0 1.1 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c PF02518.26 ACT00486.1 - 0.0017 18.8 0.1 0.0026 18.2 0.1 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF948 PF06103.11 ACT00487.1 - 7.2e-21 74.2 3.5 1.2e-20 73.6 3.5 1.3 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 ACT00487.1 - 0.00011 22.2 0.2 0.00015 21.8 0.2 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin_2 PF14523.6 ACT00487.1 - 0.0014 18.9 0.7 0.0029 17.9 0.6 1.4 1 1 0 1 1 1 1 Syntaxin-like protein Cep3 PF16846.5 ACT00487.1 - 0.0057 15.2 0.1 0.0066 15.0 0.1 1.1 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B Allexi_40kDa PF05549.11 ACT00487.1 - 0.011 15.3 0.1 0.013 15.1 0.1 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein Laminin_II PF06009.12 ACT00487.1 - 0.013 15.5 0.5 0.024 14.6 0.4 1.4 1 1 0 1 1 1 0 Laminin Domain II DUF1664 PF07889.12 ACT00487.1 - 0.017 15.1 1.1 0.092 12.8 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 ACT00487.1 - 0.034 14.5 0.3 0.12 12.8 0.3 1.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2203 PF09969.9 ACT00487.1 - 0.074 13.8 0.1 0.092 13.5 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) EzrA PF06160.12 ACT00487.1 - 0.12 10.5 0.3 0.17 10.0 0.3 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA HD_6 PF18019.1 ACT00487.1 - 0.15 12.2 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 HD domain Prominin PF05478.11 ACT00487.1 - 0.15 10.0 1.8 0.12 10.3 0.5 1.4 1 1 0 1 1 1 0 Prominin HATPase_c PF02518.26 ACT00488.1 - 1.9e-30 105.7 0.1 4.3e-30 104.5 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CHASE3 PF05227.13 ACT00488.1 - 2.5e-30 105.2 0.3 2.5e-30 105.2 0.3 3.4 3 0 0 3 3 3 1 CHASE3 domain Response_reg PF00072.24 ACT00488.1 - 1.7e-28 99.0 1.5 5.6e-28 97.3 1.5 2.0 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 ACT00488.1 - 2.1e-17 62.9 0.9 2.1e-17 62.9 0.9 3.8 3 1 1 4 4 4 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 ACT00488.1 - 5.5e-15 55.9 0.0 1.6e-14 54.4 0.0 1.9 2 0 0 2 2 1 1 GAF domain GAF PF01590.26 ACT00488.1 - 2.1e-07 31.6 0.0 1.1e-06 29.3 0.0 2.1 2 0 0 2 2 2 1 GAF domain HAMP PF00672.25 ACT00488.1 - 2.1e-07 31.2 0.2 9.4e-07 29.1 0.0 2.2 2 0 0 2 2 2 1 HAMP domain GAF_3 PF13492.6 ACT00488.1 - 0.0073 16.7 0.0 0.016 15.6 0.0 1.6 1 0 0 1 1 1 1 GAF domain AI-2E_transport PF01594.16 ACT00488.1 - 0.015 14.4 0.7 0.015 14.4 0.7 1.8 2 0 0 2 2 2 0 AI-2E family transporter HATPase_c_3 PF13589.6 ACT00488.1 - 0.076 12.8 0.3 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Atg14 PF10186.9 ACT00488.1 - 0.5 9.4 4.9 1.1 8.3 4.9 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MCU PF04678.13 ACT00488.1 - 1.4 9.0 6.1 1.6 8.8 4.0 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter LMBR1 PF04791.16 ACT00488.1 - 3.5 6.4 8.1 1.1 8.0 1.1 2.3 2 1 0 2 2 2 0 LMBR1-like membrane protein TMPIT PF07851.13 ACT00488.1 - 8.7 5.5 9.6 4.2 6.5 6.9 1.8 2 0 0 2 2 2 0 TMPIT-like protein Sec20 PF03908.13 ACT00488.1 - 9.5 6.2 8.5 13 5.7 5.8 2.7 2 0 0 2 2 2 0 Sec20 CheR PF01739.18 ACT00489.1 - 2.3e-40 138.2 0.0 3.7e-40 137.5 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.15 ACT00489.1 - 4.5e-10 39.1 1.8 1.4e-09 37.5 0.7 2.3 2 0 0 2 2 2 1 CheR methyltransferase, all-alpha domain Methyltransf_25 PF13649.6 ACT00489.1 - 0.00026 21.6 0.1 0.18 12.5 0.0 2.9 2 1 0 3 3 3 2 Methyltransferase domain Methyltransf_31 PF13847.6 ACT00489.1 - 0.0021 17.9 0.1 0.0057 16.5 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT00489.1 - 0.016 16.0 0.0 0.11 13.2 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 ACT00489.1 - 0.03 15.0 0.1 0.32 11.7 0.1 2.6 2 1 0 2 2 2 0 Methyltransferase domain ROK PF00480.20 ACT00490.1 - 6.7e-55 186.6 0.0 8.9e-55 186.2 0.0 1.2 1 0 0 1 1 1 1 ROK family MarR_2 PF12802.7 ACT00490.1 - 0.00018 21.3 0.0 0.00034 20.4 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_IclR PF09339.10 ACT00490.1 - 0.002 17.9 0.0 0.0034 17.2 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_11 PF08279.12 ACT00490.1 - 0.0083 16.0 0.5 0.02 14.9 0.5 1.7 1 0 0 1 1 1 1 HTH domain B-block_TFIIIC PF04182.12 ACT00490.1 - 0.016 15.3 0.2 0.028 14.5 0.2 1.4 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC Rrf2 PF02082.20 ACT00490.1 - 0.041 14.2 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator HTH_24 PF13412.6 ACT00490.1 - 0.052 13.1 0.5 0.1 12.2 0.5 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR PF01047.22 ACT00490.1 - 0.057 13.4 0.8 0.12 12.3 0.1 1.9 2 0 0 2 2 2 0 MarR family Cdc6_C PF09079.11 ACT00490.1 - 0.063 13.3 0.3 0.14 12.2 0.1 1.6 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain DUF2615 PF11027.8 ACT00490.1 - 0.12 12.5 0.3 0.21 11.8 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) TrmB PF01978.19 ACT00490.1 - 0.14 12.1 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB TCR PF03638.15 ACT00490.1 - 0.32 11.3 1.8 0.55 10.6 1.8 1.3 1 0 0 1 1 1 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain FGGY_N PF00370.21 ACT00491.1 - 2.5e-65 220.5 0.0 3.5e-65 220.0 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ACT00491.1 - 2.3e-37 128.6 0.3 3.3e-37 128.1 0.3 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 ACT00491.1 - 7.8e-05 22.3 0.0 0.02 14.4 0.0 2.3 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family Glyco_hydro_32N PF00251.20 ACT00492.1 - 1.8e-18 67.2 0.1 3.7e-18 66.1 0.1 1.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_43 PF04616.14 ACT00492.1 - 7.7e-05 22.1 0.3 0.00015 21.2 0.3 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32C PF08244.12 ACT00492.1 - 0.074 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 C terminal WYL PF13280.6 ACT00494.1 - 6.1e-27 94.8 0.2 1.5e-26 93.5 0.0 1.7 2 0 0 2 2 2 1 WYL domain HTH_11 PF08279.12 ACT00494.1 - 4.3e-05 23.4 0.0 0.00011 22.0 0.0 1.8 1 0 0 1 1 1 1 HTH domain HTH_DeoR PF08220.12 ACT00494.1 - 0.091 12.5 0.1 0.21 11.4 0.1 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain Dynamin_N PF00350.23 ACT00495.1 - 1.4e-12 48.0 0.5 8.6e-12 45.4 0.5 2.1 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 ACT00495.1 - 7.4e-08 32.5 0.1 1.7e-07 31.3 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ACT00495.1 - 0.0011 18.6 1.2 0.047 13.2 0.0 2.9 3 0 0 3 3 3 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 ACT00495.1 - 0.034 13.7 0.3 0.17 11.4 0.3 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ACT00495.1 - 0.051 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 ACT00496.1 - 8.4e-13 48.7 0.1 8.4e-13 48.7 0.1 3.3 3 1 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 ACT00496.1 - 1.9e-07 31.1 0.1 1.1e-06 28.6 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ACT00496.1 - 3.1e-05 23.6 3.0 6.7e-05 22.5 0.6 2.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MRP-L47 PF06984.13 ACT00496.1 - 0.021 14.9 0.4 3.9 7.7 0.0 3.7 3 0 0 3 3 3 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Baculo_PEP_C PF04513.12 ACT00496.1 - 0.062 13.3 6.0 12 5.9 0.9 3.7 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus PspA_IM30 PF04012.12 ACT00496.1 - 2.8 7.4 19.9 0.027 14.1 7.3 3.1 3 1 0 3 3 3 0 PspA/IM30 family BAG PF02179.16 ACT00496.1 - 2.9 8.4 9.8 0.57 10.7 1.8 3.9 2 2 0 2 2 2 0 BAG domain DUF87 PF01935.17 ACT00498.1 - 7.5e-15 55.6 0.1 3.4e-14 53.5 0.0 2.2 2 0 0 2 2 2 1 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 ACT00498.1 - 1.6e-08 33.9 0.0 5.5e-06 25.6 0.0 2.6 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 ACT00498.1 - 1.3e-05 24.4 0.0 3.5e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 ACT00498.1 - 5.4e-05 22.7 0.1 0.00019 20.9 0.0 1.9 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_10 PF12846.7 ACT00498.1 - 0.00017 20.7 0.2 0.00075 18.5 0.0 2.0 2 0 0 2 2 2 1 AAA-like domain AAA_22 PF13401.6 ACT00498.1 - 0.00017 21.9 0.1 0.081 13.2 0.0 3.5 3 0 0 3 3 3 1 AAA domain HrcA PF01628.21 ACT00498.1 - 0.0053 16.7 7.3 0.051 13.5 0.0 4.1 3 1 1 5 5 5 1 HrcA protein C terminal domain CobU PF02283.16 ACT00498.1 - 0.02 14.4 0.0 20 4.7 0.0 3.6 3 0 0 3 3 3 0 Cobinamide kinase / cobinamide phosphate guanyltransferase DUF2075 PF09848.9 ACT00498.1 - 0.022 14.0 0.1 2.7 7.2 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 ACT00498.1 - 0.032 13.7 0.0 0.098 12.2 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 ACT00498.1 - 0.2 11.5 1.8 7.7 6.4 0.0 3.3 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea HNH PF01844.23 ACT00499.1 - 0.0017 18.5 0.0 0.0031 17.6 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease HNH_4 PF13395.6 ACT00499.1 - 0.0038 17.1 0.0 0.0074 16.2 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease HNH_5 PF14279.6 ACT00499.1 - 0.061 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 HNH endonuclease Zeta_toxin PF06414.12 ACT00502.1 - 5.6e-10 38.8 0.1 1.4e-09 37.5 0.1 1.6 1 1 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 ACT00502.1 - 0.00038 20.6 0.0 0.0006 20.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ACT00502.1 - 0.0026 18.3 0.1 0.0054 17.2 0.1 1.7 1 1 1 2 2 2 1 ABC transporter CoaE PF01121.20 ACT00502.1 - 0.005 16.5 0.1 0.011 15.4 0.0 1.6 2 0 0 2 2 2 1 Dephospho-CoA kinase AAA_23 PF13476.6 ACT00502.1 - 0.0061 17.1 0.2 0.0095 16.5 0.2 1.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT00502.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 ACT00502.1 - 0.029 14.3 0.1 5 7.0 0.0 2.1 2 0 0 2 2 2 0 NTPase RsgA_GTPase PF03193.16 ACT00502.1 - 0.075 12.9 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_21 PF13304.6 ACT00502.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system HTH_18 PF12833.7 ACT00504.1 - 9.2e-17 61.1 0.0 1.9e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00504.1 - 1.2e-15 57.2 0.0 1.2e-07 31.7 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Glyoxalase PF00903.25 ACT00505.1 - 1.8e-09 37.8 0.1 2.6e-09 37.4 0.1 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ACT00505.1 - 5.1e-05 23.2 0.0 6.7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyco_hydro_3 PF00933.21 ACT00508.1 - 2.5e-44 151.9 1.7 3.9e-44 151.3 0.3 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ACT00508.1 - 3.2e-30 105.6 3.9 3.2e-30 105.6 3.9 3.2 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ACT00508.1 - 2.7e-15 56.2 0.0 1.2e-14 54.2 0.0 2.2 2 0 0 2 2 2 1 Fibronectin type III-like domain Cohesin PF00963.18 ACT00508.1 - 1.2e-09 38.5 2.3 1.2e-09 38.5 2.3 3.6 3 0 0 3 3 3 1 Cohesin domain FIVAR PF07554.13 ACT00508.1 - 7e-06 26.7 33.1 4e-05 24.3 10.1 4.3 4 0 0 4 4 4 2 FIVAR domain DUF5001 PF16392.5 ACT00508.1 - 3.6 7.6 5.6 1.1 9.2 0.4 2.9 4 0 0 4 4 4 0 Ig-like domain SLH PF00395.20 ACT00509.1 - 1.5e-44 149.8 4.5 6.3e-15 54.9 0.1 3.3 3 0 0 3 3 3 3 S-layer homology domain Cohesin PF00963.18 ACT00509.1 - 0.0002 21.6 1.4 0.0002 21.6 1.4 2.5 2 1 0 2 2 2 1 Cohesin domain Integrase_1 PF12835.7 ACT00509.1 - 0.069 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Integrase Peripla_BP_4 PF13407.6 ACT00510.1 - 2.8e-59 200.8 0.6 3.3e-59 200.5 0.6 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACT00510.1 - 4e-23 82.2 0.2 5.1e-23 81.9 0.2 1.0 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 ACT00510.1 - 1.5e-10 41.6 0.0 2.7e-09 37.5 0.0 2.1 2 0 0 2 2 2 1 Periplasmic binding protein-like domain ABC_sub_bind PF04392.12 ACT00510.1 - 0.00053 19.3 0.5 0.0032 16.8 0.1 2.1 1 1 1 2 2 2 1 ABC transporter substrate binding protein Ribosomal_S2 PF00318.20 ACT00510.1 - 0.088 12.0 0.2 8.5 5.5 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein S2 His_kinase PF06580.13 ACT00511.1 - 2.1e-25 88.8 1.0 2.1e-25 88.8 1.0 3.3 3 1 1 4 4 4 1 Histidine kinase HATPase_c PF02518.26 ACT00511.1 - 1e-10 42.1 0.0 2.3e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT00511.1 - 7.9e-09 35.8 0.0 2.2e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 HAMP domain NADH5_C PF06455.11 ACT00511.1 - 4.3 6.9 12.5 0.067 12.8 2.8 2.5 1 1 2 3 3 3 0 NADH dehydrogenase subunit 5 C-terminus Response_reg PF00072.24 ACT00512.1 - 7.6e-25 87.3 0.3 2.1e-24 85.9 0.3 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00512.1 - 4e-22 78.3 0.0 1.2e-21 76.8 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00512.1 - 3e-21 75.0 0.2 3.2e-11 43.0 0.0 3.1 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT00512.1 - 0.0004 20.6 0.0 0.00094 19.4 0.0 1.6 1 0 0 1 1 1 1 GGDEF-like domain UPF0122 PF04297.14 ACT00512.1 - 0.036 14.3 0.8 0.22 11.8 0.2 2.7 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like ER PF01133.17 ACT00512.1 - 0.3 11.1 2.8 0.49 10.5 0.3 2.6 3 0 0 3 3 3 0 Enhancer of rudimentary SBP_bac_1 PF01547.25 ACT00513.1 - 1.7e-30 107.0 2.0 2.2e-30 106.7 2.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT00513.1 - 7.1e-23 81.8 0.3 1.1e-22 81.2 0.3 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT00513.1 - 0.0088 15.5 0.2 0.26 10.6 0.0 2.3 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein Peripla_BP_4 PF13407.6 ACT00514.1 - 7.3e-61 206.0 14.5 7.3e-61 206.0 14.5 1.5 2 0 0 2 2 2 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACT00514.1 - 8.8e-06 25.3 3.0 2.6e-05 23.8 2.7 1.9 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 ACT00514.1 - 1.5e-05 25.4 0.1 4.6e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 Periplasmic binding protein-like domain ABC_tran PF00005.27 ACT00515.1 - 4.5e-52 176.2 0.0 5.4e-28 98.2 0.0 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACT00515.1 - 3.1e-09 37.1 0.1 0.018 14.9 0.0 3.2 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT00515.1 - 9.2e-05 22.1 0.0 0.00021 21.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.9 ACT00515.1 - 0.00013 20.9 2.7 2.5 6.8 0.1 4.3 4 1 0 4 4 4 2 Predicted ATPase of the ABC class AAA_23 PF13476.6 ACT00515.1 - 0.00056 20.5 0.1 0.0013 19.3 0.0 1.7 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.19 ACT00515.1 - 0.0019 17.7 0.2 0.14 11.5 0.0 2.7 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ACT00515.1 - 0.0051 16.7 0.1 0.024 14.6 0.0 2.1 3 0 0 3 3 3 1 RsgA GTPase MukB PF04310.12 ACT00515.1 - 0.0052 16.6 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 MukB N-terminal AAA PF00004.29 ACT00515.1 - 0.027 14.9 0.5 0.4 11.1 0.5 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ACT00515.1 - 0.039 14.2 0.1 0.59 10.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ACT00515.1 - 0.089 12.5 0.0 0.21 11.2 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Tnp_P_element PF12017.8 ACT00515.1 - 0.13 11.7 0.3 1.7 8.0 0.3 2.3 2 0 0 2 2 2 0 Transposase protein AAA_30 PF13604.6 ACT00515.1 - 0.15 11.7 0.1 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain BPD_transp_2 PF02653.16 ACT00516.1 - 1.3e-46 159.0 33.7 2e-46 158.4 33.7 1.3 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component HATPase_c_2 PF13581.6 ACT00517.1 - 1.4e-21 76.7 0.0 1.6e-21 76.6 0.0 1.0 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c PF02518.26 ACT00517.1 - 0.041 14.4 0.0 0.062 13.8 0.0 1.3 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase STAS_2 PF13466.6 ACT00518.1 - 4.2e-12 46.2 0.0 4.8e-12 46.0 0.0 1.0 1 0 0 1 1 1 1 STAS domain STAS PF01740.21 ACT00518.1 - 2.6e-07 30.3 0.0 3.3e-07 29.9 0.0 1.0 1 0 0 1 1 1 1 STAS domain SpoIIE PF07228.12 ACT00520.1 - 5.9e-32 111.2 0.0 8e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Response_reg PF00072.24 ACT00520.1 - 9.1e-26 90.2 3.2 5.6e-25 87.7 1.0 2.4 2 0 0 2 2 2 1 Response regulator receiver domain Abhydrolase_1 PF00561.20 ACT00520.1 - 0.07 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold YflT PF11181.8 ACT00521.1 - 4.7e-30 104.0 1.7 5.8e-30 103.8 1.7 1.1 1 0 0 1 1 1 1 Heat induced stress protein YflT DUF4473 PF14747.6 ACT00521.1 - 0.09 13.3 0.0 0.19 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) DUF5333 PF17267.2 ACT00521.1 - 0.097 12.9 0.4 0.56 10.4 0.1 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5333) DUF1328 PF07043.13 ACT00522.1 - 1.9e-12 47.2 25.6 2.5e-12 46.8 25.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1328) DUF805 PF05656.14 ACT00522.1 - 2.2 8.7 5.8 2.3 8.7 5.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF805) GDPD PF03009.17 ACT00523.1 - 2.3e-41 142.2 0.0 6.8e-41 140.7 0.0 1.6 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.19 ACT00523.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain BPD_transp_1 PF00528.22 ACT00524.1 - 1.4e-17 64.1 15.0 1.4e-17 64.1 15.0 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00525.1 - 6.5e-15 55.4 25.6 6.4e-14 52.1 25.6 2.2 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACT00526.1 - 2e-50 172.2 11.9 2.8e-50 171.7 11.9 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT00526.1 - 2.3e-39 136.2 11.3 3.4e-39 135.6 11.3 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT00526.1 - 7.8e-05 22.2 0.7 0.0013 18.2 0.1 2.4 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT00526.1 - 0.00032 20.5 1.1 2.6 7.8 0.0 3.4 2 1 0 2 2 2 2 Bacterial extracellular solute-binding protein Abhydrolase_1 PF00561.20 ACT00527.1 - 2.5e-27 96.1 0.1 8.6e-25 87.8 0.1 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ACT00527.1 - 5e-20 71.8 0.0 6.1e-20 71.5 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ACT00527.1 - 1.6e-18 68.1 0.0 2e-18 67.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 ACT00527.1 - 3.4e-08 32.5 0.0 4.6e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Ndr family Thioesterase PF00975.20 ACT00527.1 - 8.6e-08 32.6 0.0 3.7e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 Thioesterase domain Abhydrolase_2 PF02230.16 ACT00527.1 - 4e-07 30.1 0.1 0.0043 16.9 0.0 3.1 1 1 0 3 3 3 2 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.7 ACT00527.1 - 0.00013 21.7 0.0 0.0021 17.8 0.0 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family Esterase PF00756.20 ACT00527.1 - 0.00059 19.6 0.0 0.001 18.8 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 ACT00527.1 - 0.0015 18.4 0.0 0.0029 17.5 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF1057 PF06342.12 ACT00527.1 - 0.0018 17.4 0.0 0.002 17.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) UPF0227 PF05728.12 ACT00527.1 - 0.0028 17.6 0.0 0.007 16.3 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Peptidase_S9 PF00326.21 ACT00527.1 - 0.0041 16.6 0.0 0.22 11.0 0.0 2.3 2 0 0 2 2 2 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 ACT00527.1 - 0.012 14.6 0.0 0.019 13.9 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme AXE1 PF05448.12 ACT00527.1 - 0.015 14.0 0.2 8.3 5.0 0.0 3.0 2 1 1 3 3 3 0 Acetyl xylan esterase (AXE1) Palm_thioest PF02089.15 ACT00527.1 - 0.035 13.9 0.0 0.88 9.4 0.0 2.1 2 0 0 2 2 2 0 Palmitoyl protein thioesterase LIDHydrolase PF10230.9 ACT00527.1 - 0.04 13.5 0.0 0.061 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 ACT00527.1 - 0.065 13.1 0.0 0.42 10.5 0.0 2.0 2 0 0 2 2 2 0 Lipase (class 3) 3-dmu-9_3-mt PF06983.13 ACT00528.1 - 6.2e-11 42.9 0.0 7.2e-11 42.7 0.0 1.0 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase Glyoxalase PF00903.25 ACT00528.1 - 7.4e-10 39.1 0.1 9.4e-10 38.8 0.1 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ACT00528.1 - 0.00037 21.3 0.0 0.00046 20.9 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain DAPDH_C PF16654.5 ACT00528.1 - 0.11 12.3 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Diaminopimelic acid dehydrogenase C-terminal domain Cys_rich_CWC PF14375.6 ACT00529.1 - 1.7e-15 57.1 10.8 2.1e-15 56.8 10.8 1.1 1 0 0 1 1 1 1 Cysteine-rich CWC Endonuclease_1 PF04231.13 ACT00529.1 - 0.19 11.4 0.2 0.18 11.4 0.2 1.1 1 0 0 1 1 1 0 Endonuclease I zf-C3HC4_3 PF13920.6 ACT00529.1 - 0.24 11.3 9.0 0.3 11.0 0.3 2.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF1806 PF08830.10 ACT00530.1 - 1.5e-24 86.0 0.1 3.1e-22 78.6 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1806) PIG-L PF02585.17 ACT00531.1 - 1.4e-33 116.3 0.0 2.7e-33 115.4 0.0 1.5 2 0 0 2 2 2 1 GlcNAc-PI de-N-acetylase ETF PF01012.21 ACT00531.1 - 0.014 15.3 0.0 0.026 14.4 0.0 1.4 1 1 0 1 1 1 0 Electron transfer flavoprotein domain HMGL-like PF00682.19 ACT00531.1 - 0.077 12.5 0.1 0.13 11.8 0.0 1.5 1 1 0 1 1 1 0 HMGL-like Acyl-CoA_dh_2 PF08028.11 ACT00532.1 - 2.3e-19 70.0 0.0 4.2e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_1 PF00441.24 ACT00532.1 - 1.4e-17 64.3 0.0 2.6e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ACT00532.1 - 5e-10 40.0 0.4 1.7e-09 38.3 0.1 2.0 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ACT00532.1 - 1.8e-09 37.7 0.0 3.3e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Adenine_deam_C PF13382.6 ACT00533.1 - 7.9e-61 204.3 0.0 1.4e-60 203.5 0.0 1.4 1 0 0 1 1 1 1 Adenine deaminase C-terminal domain Amidohydro_1 PF01979.20 ACT00533.1 - 4.1e-36 125.0 0.3 8.6e-36 123.9 0.3 1.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ACT00533.1 - 1.2e-13 51.4 0.5 1.5e-06 28.0 0.0 2.5 2 0 0 2 2 2 2 Amidohydrolase family Urease_alpha PF00449.20 ACT00533.1 - 0.018 15.4 2.6 0.042 14.2 2.6 1.6 1 0 0 1 1 1 0 Urease alpha-subunit, N-terminal domain Hpt PF01627.23 ACT00533.1 - 0.076 13.3 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 Hpt domain His_Phos_1 PF00300.22 ACT00534.1 - 2.4e-33 115.5 0.0 2.1e-26 92.8 0.1 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) MFS_1 PF07690.16 ACT00535.1 - 9.5e-47 159.6 69.9 9.6e-39 133.3 43.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 ACT00535.1 - 0.00077 18.3 1.4 0.00077 18.3 1.4 2.5 2 2 0 2 2 2 1 LacY proton/sugar symporter MFS_4 PF06779.14 ACT00535.1 - 0.0011 18.4 31.4 0.0015 17.9 31.4 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 ACT00535.1 - 1.2 7.9 34.7 0.096 11.5 15.4 2.6 1 1 0 2 2 2 0 Sugar (and other) transporter Pyr_redox_2 PF07992.14 ACT00536.1 - 3.3e-32 111.9 0.7 4.3e-32 111.5 0.7 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT00536.1 - 6.7e-05 23.4 2.7 0.0016 19.0 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ACT00536.1 - 0.21 11.6 1.8 14 5.6 0.0 3.2 3 1 0 3 3 3 0 FAD-NAD(P)-binding Sigma70_r2 PF04542.14 ACT00537.1 - 2e-18 65.9 0.1 2.3e-17 62.5 0.0 2.2 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT00537.1 - 8.9e-14 50.9 0.3 1.7e-13 50.0 0.3 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT00537.1 - 0.00044 19.7 0.1 0.0023 17.4 0.0 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 SnoaL_2 PF12680.7 ACT00537.1 - 0.0025 18.4 0.0 0.0048 17.5 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain GFO_IDH_MocA PF01408.22 ACT00538.1 - 1.5e-30 106.5 0.1 2.6e-30 105.7 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT00538.1 - 3.9e-09 36.5 0.0 1.2e-07 31.7 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACT00538.1 - 3.3e-06 27.7 0.6 1.7e-05 25.4 0.1 2.0 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 ACT00539.1 - 2e-20 73.8 0.3 4.4e-20 72.7 0.3 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ACT00539.1 - 1.1e-06 29.3 0.3 2e-06 28.4 0.3 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.17 ACT00539.1 - 1.1e-06 28.6 0.0 4.9e-06 26.5 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain HTH_18 PF12833.7 ACT00540.1 - 8.1e-19 67.7 0.9 3.3e-18 65.7 0.2 2.1 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00540.1 - 1.8e-14 53.4 0.1 5.9e-07 29.4 0.0 2.6 1 1 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT00540.1 - 1.2e-07 31.7 0.5 3.5e-07 30.2 0.3 1.8 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT00540.1 - 1.9e-07 30.7 0.3 3.8e-07 29.7 0.3 1.5 1 0 0 1 1 1 1 Cupin domain Auxin_BP PF02041.16 ACT00540.1 - 0.0085 15.8 0.0 0.022 14.4 0.0 1.6 1 0 0 1 1 1 1 Auxin binding protein HTH_Tnp_ISL3 PF13542.6 ACT00540.1 - 0.016 14.6 0.1 0.064 12.7 0.0 2.1 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 ACT00540.1 - 0.026 14.3 0.1 0.082 12.7 0.1 1.8 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4 PF04545.16 ACT00540.1 - 0.12 12.0 0.0 0.33 10.5 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 Ectoine_synth PF06339.12 ACT00540.1 - 0.13 12.5 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Ectoine synthase UPF0122 PF04297.14 ACT00540.1 - 0.16 12.3 0.3 11 6.3 0.1 2.3 1 1 1 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like HTH_18 PF12833.7 ACT00541.1 - 4.9e-25 87.6 0.1 9.3e-25 86.7 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00541.1 - 2e-15 56.4 0.3 4e-08 33.2 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Sigma70_ner PF04546.13 ACT00541.1 - 0.041 13.8 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region HTH_31 PF13560.6 ACT00541.1 - 0.13 12.7 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MFS_1 PF07690.16 ACT00542.1 - 1.2e-51 175.7 46.4 1.2e-51 175.7 46.4 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 ACT00542.1 - 0.00017 20.0 3.2 0.00017 20.0 3.2 3.2 2 1 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family O-ag_pol_Wzy PF14296.6 ACT00543.1 - 0.15 10.7 0.0 0.2 10.2 0.0 1.1 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy PRK PF00485.18 ACT00544.1 - 7.8e-46 156.3 0.0 9e-46 156.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 ACT00544.1 - 1.4e-08 35.3 0.0 1.9e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ACT00544.1 - 1.1e-05 24.8 0.1 3.1e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin dNK PF01712.19 ACT00544.1 - 4.9e-05 23.3 0.0 0.00011 22.2 0.0 1.5 1 1 0 1 1 1 1 Deoxynucleoside kinase AAA_33 PF13671.6 ACT00544.1 - 0.00029 21.0 0.0 0.00038 20.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ACT00544.1 - 0.00066 20.1 1.0 0.69 10.3 0.4 2.3 2 1 0 2 2 2 2 AAA domain CoaE PF01121.20 ACT00544.1 - 0.00073 19.2 0.5 0.081 12.6 0.1 2.3 2 0 0 2 2 2 1 Dephospho-CoA kinase Cytidylate_kin PF02224.18 ACT00544.1 - 0.0012 18.6 0.4 0.27 10.9 0.4 2.1 1 1 0 1 1 1 1 Cytidylate kinase AAA_16 PF13191.6 ACT00544.1 - 0.0019 18.6 0.1 0.0054 17.1 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT00544.1 - 0.0042 17.4 0.1 0.016 15.4 0.1 1.9 1 1 1 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 ACT00544.1 - 0.0097 15.6 0.3 3.2 7.4 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase T2SSE PF00437.20 ACT00544.1 - 0.034 13.2 0.4 0.055 12.5 0.1 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_26 PF13500.6 ACT00544.1 - 0.039 13.8 0.0 0.091 12.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 ACT00544.1 - 0.046 13.8 1.2 0.15 12.1 1.2 2.1 1 1 0 1 1 1 0 Helicase HerA, central domain AAA PF00004.29 ACT00544.1 - 0.064 13.7 0.1 0.15 12.5 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ACT00544.1 - 0.073 13.6 0.0 0.12 12.8 0.0 1.3 1 1 0 1 1 1 0 ABC transporter ATPase_2 PF01637.18 ACT00544.1 - 0.081 12.8 0.1 0.1 12.5 0.1 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Tubulin PF00091.25 ACT00544.1 - 0.1 12.8 1.0 0.15 12.3 0.4 1.7 2 1 0 2 2 2 0 Tubulin/FtsZ family, GTPase domain MobB PF03205.14 ACT00544.1 - 0.14 12.1 0.0 1.4 8.8 0.0 2.5 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.6 ACT00544.1 - 0.2 12.0 0.2 0.45 10.9 0.2 1.5 1 0 0 1 1 1 0 AAA domain Cytidylate_kin2 PF13189.6 ACT00544.1 - 0.21 11.7 1.3 0.55 10.4 1.3 1.7 1 1 0 1 1 1 0 Cytidylate kinase-like family FGGY_N PF00370.21 ACT00545.1 - 2.7e-50 171.3 0.0 4.1e-50 170.6 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ACT00545.1 - 1.4e-31 109.8 0.0 3.2e-31 108.6 0.0 1.6 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain HSP70 PF00012.20 ACT00545.1 - 0.017 13.3 0.0 0.043 12.0 0.0 1.5 2 0 0 2 2 2 0 Hsp70 protein MFS_1 PF07690.16 ACT00546.1 - 6.3e-32 110.9 47.6 6.3e-32 110.9 47.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT00546.1 - 8.7e-09 34.7 30.9 4.9e-05 22.4 15.8 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.6 ACT00546.1 - 2.8e-06 26.2 33.8 5.5e-06 25.2 10.2 2.8 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 ACT00546.1 - 0.039 12.8 24.1 0.35 9.7 7.9 3.1 1 1 2 3 3 3 0 MFS_1 like family Aldolase_II PF00596.21 ACT00547.1 - 1.1e-46 159.1 0.1 1.8e-38 132.4 0.1 2.1 2 0 0 2 2 2 2 Class II Aldolase and Adducin N-terminal domain DUF2379 PF09543.10 ACT00547.1 - 0.061 13.5 0.0 0.22 11.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2379) Aminotran_3 PF00202.21 ACT00548.1 - 4e-51 173.9 0.0 6.7e-51 173.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ACT00548.1 - 0.0071 15.6 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Y_phosphatase3 PF13350.6 ACT00549.1 - 1.3e-60 205.3 0.1 1.4e-60 205.1 0.1 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ACT00549.1 - 0.037 13.6 0.1 0.19 11.3 0.0 1.8 1 1 1 2 2 2 0 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 ACT00549.1 - 0.065 12.8 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Metallophos PF00149.28 ACT00550.1 - 5.9e-17 62.8 0.2 8.7e-17 62.3 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACT00550.1 - 1.9e-05 25.0 0.0 4.6e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain GntR PF00392.21 ACT00551.1 - 3.3e-18 65.1 1.3 5.5e-18 64.4 0.5 1.8 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family FCD PF07729.12 ACT00551.1 - 8e-12 45.7 0.2 1.2e-11 45.1 0.2 1.3 1 0 0 1 1 1 1 FCD domain HTH_Crp_2 PF13545.6 ACT00551.1 - 0.00037 20.4 0.1 0.00083 19.3 0.1 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 ACT00551.1 - 0.00084 18.8 0.3 0.0025 17.3 0.1 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 ACT00551.1 - 0.006 16.9 0.0 0.032 14.6 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulator PSII_Pbs31 PF18240.1 ACT00551.1 - 0.017 15.6 0.0 0.035 14.6 0.0 1.5 1 0 0 1 1 1 0 Photosystem II Psb31 protein HTH_54 PF18607.1 ACT00551.1 - 0.03 14.4 1.0 7.4 6.7 0.4 2.4 2 0 0 2 2 2 0 ParA helix turn helix domain DUF1670 PF07900.11 ACT00551.1 - 0.03 13.7 0.0 0.068 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1670) HTH_11 PF08279.12 ACT00551.1 - 0.032 14.2 0.0 0.082 12.9 0.0 1.7 1 0 0 1 1 1 0 HTH domain Polysacc_synt_2 PF02719.15 ACT00551.1 - 0.046 12.9 0.1 0.06 12.5 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein HTH_29 PF13551.6 ACT00551.1 - 0.1 12.6 0.1 0.33 11.0 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn helix GntR PF00392.21 ACT00552.1 - 1.2e-09 37.7 0.0 2.5e-09 36.6 0.0 1.6 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Fe_dep_repress PF01325.19 ACT00552.1 - 7.1e-06 26.1 0.0 1.6e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_Crp_2 PF13545.6 ACT00552.1 - 9.5e-05 22.3 0.0 0.00036 20.5 0.0 1.9 1 1 1 2 2 2 1 Crp-like helix-turn-helix domain HTH_41 PF14502.6 ACT00552.1 - 0.00011 21.8 0.0 0.00024 20.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_36 PF13730.6 ACT00552.1 - 0.00078 19.4 0.0 0.0022 17.9 0.0 1.9 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.6 ACT00552.1 - 0.00087 18.8 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding LexA_DNA_bind PF01726.16 ACT00552.1 - 0.0011 18.7 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 LexA DNA binding domain MarR_2 PF12802.7 ACT00552.1 - 0.0019 18.0 0.0 0.0032 17.3 0.0 1.4 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.20 ACT00552.1 - 0.0023 18.3 0.0 0.0047 17.2 0.0 1.6 1 1 0 1 1 1 1 Transcriptional regulator RepL PF05732.11 ACT00552.1 - 0.0066 15.9 0.1 0.0091 15.4 0.1 1.2 1 0 0 1 1 1 1 Firmicute plasmid replication protein (RepL) TrmB PF01978.19 ACT00552.1 - 0.028 14.3 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 ACT00552.1 - 0.029 14.3 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_54 PF18607.1 ACT00552.1 - 0.031 14.4 0.2 0.48 10.5 0.0 2.1 1 1 1 2 2 2 0 ParA helix turn helix domain HTH_23 PF13384.6 ACT00552.1 - 0.06 13.2 0.0 0.12 12.2 0.0 1.5 1 1 0 1 1 1 0 Homeodomain-like domain HTH_28 PF13518.6 ACT00552.1 - 0.073 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_45 PF14947.6 ACT00552.1 - 0.073 13.1 0.1 4.4 7.4 0.0 2.2 1 1 1 2 2 2 0 Winged helix-turn-helix GerE PF00196.19 ACT00552.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family DUF3139 PF11337.8 ACT00553.1 - 4.9 7.9 9.2 0.26 12.0 0.7 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF3139) AglB_L1 PF18079.1 ACT00555.1 - 0.095 13.0 0.4 0.31 11.4 0.3 1.8 2 0 0 2 2 2 0 Archaeal glycosylation protein B long peripheral domain SKG6 PF08693.10 ACT00555.1 - 0.8 9.2 6.5 1.5 8.3 6.5 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain ABC_tran PF00005.27 ACT00556.1 - 5.5e-19 69.0 0.0 1e-18 68.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00556.1 - 0.00012 22.0 0.7 0.00056 19.8 0.3 2.0 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ACT00556.1 - 0.00046 20.8 0.2 0.0018 18.8 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ACT00556.1 - 0.0024 17.6 0.2 0.0045 16.7 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DLIC PF05783.11 ACT00556.1 - 0.0037 16.2 0.1 0.0053 15.6 0.1 1.1 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) SMC_N PF02463.19 ACT00556.1 - 0.0078 15.7 0.6 0.015 14.8 0.1 1.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain NACHT PF05729.12 ACT00556.1 - 0.0081 16.1 0.2 0.013 15.4 0.2 1.3 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ACT00556.1 - 0.012 16.0 0.1 0.014 15.8 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_15 PF13175.6 ACT00556.1 - 0.037 13.7 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 ACT00556.1 - 0.055 13.0 0.3 0.12 11.9 0.1 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_ATPase PF09818.9 ACT00556.1 - 0.057 12.2 0.9 0.084 11.7 0.2 1.5 2 0 0 2 2 2 0 Predicted ATPase of the ABC class NB-ARC PF00931.22 ACT00556.1 - 0.082 12.1 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 ACT00556.1 - 0.086 13.4 0.1 0.2 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ACT00556.1 - 0.12 12.7 0.2 0.23 11.7 0.2 1.8 1 1 0 1 1 1 0 AAA domain Arg_repressor_C PF02863.18 ACT00556.1 - 0.14 12.0 0.1 0.31 10.9 0.1 1.5 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain TAT_signal PF10518.9 ACT00556.1 - 0.18 11.7 0.2 0.34 10.8 0.2 1.5 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence HTH_24 PF13412.6 ACT00557.1 - 5.8e-12 45.0 0.1 1e-11 44.2 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 ACT00557.1 - 6.6e-12 45.1 0.1 1.1e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 ACT00557.1 - 2.1e-07 30.8 0.0 3.3e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_20 PF12840.7 ACT00557.1 - 0.0014 18.7 0.0 0.0022 18.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 ACT00557.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 0 MarR family Lactamase_B_3 PF13483.6 ACT00558.1 - 6.4e-15 55.4 0.0 9.6e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 ACT00558.1 - 1.7e-13 50.5 0.0 2.2e-13 50.2 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACT00558.1 - 0.041 13.9 0.3 0.057 13.4 0.3 1.4 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Succ_CoA_lig PF13607.6 ACT00558.1 - 0.061 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain PIRT PF15099.6 ACT00558.1 - 0.15 11.6 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Abhydrolase_1 PF00561.20 ACT00559.1 - 3.2e-16 59.8 0.0 2.4e-12 47.1 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACT00559.1 - 9.3e-14 52.6 0.0 1.6e-13 51.8 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACT00559.1 - 7.7e-12 45.0 0.1 2.2e-11 43.5 0.1 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 ACT00559.1 - 2.3e-05 23.2 0.0 9.5e-05 21.2 0.0 1.8 2 0 0 2 2 2 1 Ndr family BAAT_C PF08840.11 ACT00559.1 - 3.9e-05 23.7 0.0 7.9e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_4 PF08386.10 ACT00559.1 - 0.0001 22.4 0.0 0.00023 21.2 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein FSH1 PF03959.13 ACT00559.1 - 0.00025 20.8 0.0 0.0033 17.1 0.0 2.0 1 1 1 2 2 2 1 Serine hydrolase (FSH1) Thioesterase PF00975.20 ACT00559.1 - 0.0014 18.7 0.1 0.0015 18.7 0.1 1.2 1 0 0 1 1 1 1 Thioesterase domain Lactamase_B_2 PF12706.7 ACT00560.1 - 2.5e-20 72.8 0.4 3.2e-20 72.5 0.4 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ACT00560.1 - 1.6e-12 47.6 0.0 2.2e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACT00560.1 - 0.5 10.3 10.4 2.3 8.2 0.2 2.3 2 1 0 2 2 2 0 Metallo-beta-lactamase superfamily SNF2_assoc PF08455.10 ACT00561.1 - 3.4e-91 306.1 0.0 4.8e-91 305.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial SNF2 helicase associated SNF2_N PF00176.23 ACT00561.1 - 4.2e-53 180.3 0.0 7.6e-53 179.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ACT00561.1 - 4e-22 78.7 0.0 1.6e-21 76.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT00561.1 - 2.8e-06 27.4 0.0 6.1e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWIM PF04434.17 ACT00561.1 - 4.8e-05 22.9 0.2 0.00011 21.8 0.2 1.6 1 0 0 1 1 1 1 SWIM zinc finger SWI2_SNF2 PF18766.1 ACT00561.1 - 0.0014 18.3 0.0 0.0043 16.7 0.0 1.8 1 1 0 1 1 1 1 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 ACT00561.1 - 0.039 13.1 0.0 0.067 12.4 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase MarR PF01047.22 ACT00562.1 - 5.8e-14 51.8 0.1 1.4e-13 50.5 0.0 1.8 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.7 ACT00562.1 - 1.1e-10 41.2 0.2 2.6e-10 40.0 0.2 1.6 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT00562.1 - 6.2e-05 22.5 0.0 0.00014 21.4 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_23 PF13384.6 ACT00562.1 - 0.00029 20.5 0.1 0.0018 18.0 0.0 2.3 3 0 0 3 3 3 1 Homeodomain-like domain HTH_27 PF13463.6 ACT00562.1 - 0.00051 20.5 0.0 0.0012 19.3 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain Fe_dep_repress PF01325.19 ACT00562.1 - 0.002 18.3 0.0 0.004 17.3 0.0 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_Crp_2 PF13545.6 ACT00562.1 - 0.0023 17.9 0.1 0.0051 16.7 0.1 1.8 1 1 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_28 PF13518.6 ACT00562.1 - 0.0031 17.6 0.0 0.005 16.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain B-block_TFIIIC PF04182.12 ACT00562.1 - 0.0044 17.1 0.0 0.0062 16.7 0.0 1.3 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_1 PF00126.27 ACT00562.1 - 0.017 15.1 0.0 0.041 13.8 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family DUF4423 PF14394.6 ACT00562.1 - 0.025 14.3 0.0 0.031 14.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Rrf2 PF02082.20 ACT00562.1 - 0.03 14.7 0.0 0.059 13.7 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator Plasmid_stab_B PF10784.9 ACT00562.1 - 0.032 14.0 0.0 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 Plasmid stability protein HTH_47 PF16221.5 ACT00562.1 - 0.051 13.1 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 winged helix-turn-helix HTH_IclR PF09339.10 ACT00562.1 - 0.057 13.2 0.0 0.057 13.2 0.0 2.9 4 1 0 4 4 4 0 IclR helix-turn-helix domain GntR PF00392.21 ACT00562.1 - 0.071 12.8 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Terminase_5 PF06056.12 ACT00562.1 - 0.092 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_10 PF04967.12 ACT00562.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain ADH_zinc_N_2 PF13602.6 ACT00563.1 - 2.5e-23 83.6 0.1 5.2e-23 82.6 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ACT00563.1 - 1.4e-13 50.9 0.0 2.3e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ACT00563.1 - 2.1e-09 37.2 0.0 8.9e-09 35.2 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glyco_hydro_43 PF04616.14 ACT00564.1 - 1.3e-32 113.3 5.5 9e-32 110.5 5.5 2.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 WYL PF13280.6 ACT00564.1 - 0.15 12.1 0.3 18 5.3 0.0 2.9 2 1 1 3 3 3 0 WYL domain Collagen PF01391.18 ACT00565.1 - 7.6e-66 217.8 252.3 7.9e-08 31.9 29.8 10.3 2 2 3 5 5 5 4 Collagen triple helix repeat (20 copies) Glycos_transf_2 PF00535.26 ACT00566.1 - 1.9e-19 70.1 1.1 4.3e-19 68.9 1.1 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 2 TPR_8 PF13181.6 ACT00566.1 - 5.8e-05 23.0 1.9 0.48 10.8 0.4 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat Glyco_tranf_2_4 PF13704.6 ACT00566.1 - 9.6e-05 22.8 2.5 0.0013 19.2 1.4 3.1 2 1 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 ACT00566.1 - 0.0001 21.9 0.0 0.00017 21.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 TPR_1 PF00515.28 ACT00566.1 - 0.0019 17.9 9.8 2.6 8.0 0.7 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ACT00566.1 - 0.016 15.5 2.2 23 5.4 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ACT00566.1 - 0.017 15.1 5.8 16 5.8 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ACT00566.1 - 0.17 12.1 15.2 1.2 9.4 1.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ACT00566.1 - 0.17 12.1 0.1 0.17 12.1 0.1 3.1 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ACT00566.1 - 0.18 12.3 1.9 29 5.3 0.1 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat HTH_18 PF12833.7 ACT00567.1 - 1.5e-21 76.4 0.5 3.5e-21 75.3 0.5 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00567.1 - 1.8e-20 72.5 0.2 1.5e-09 37.7 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT00567.1 - 7.2e-09 35.7 0.2 2e-08 34.2 0.1 1.8 2 1 0 2 2 2 1 AraC-like ligand binding domain AraC_binding_2 PF14525.6 ACT00567.1 - 7.2e-05 22.5 0.5 0.00013 21.7 0.5 1.4 1 0 0 1 1 1 1 AraC-binding-like domain HTH_28 PF13518.6 ACT00567.1 - 0.0003 20.9 0.1 0.026 14.6 0.0 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 ACT00567.1 - 0.00032 20.4 0.0 0.11 12.3 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain Rrf2 PF02082.20 ACT00567.1 - 0.0004 20.7 0.2 0.0074 16.6 0.1 2.3 2 0 0 2 2 2 1 Transcriptional regulator HTH_Tnp_1 PF01527.20 ACT00567.1 - 0.00091 19.5 0.5 0.53 10.6 0.0 2.7 3 0 0 3 3 2 1 Transposase Cupin_2 PF07883.11 ACT00567.1 - 0.00091 18.9 0.2 0.0019 17.8 0.2 1.6 1 1 0 1 1 1 1 Cupin domain TetR_N PF00440.23 ACT00567.1 - 0.00098 18.9 0.1 0.045 13.6 0.1 2.5 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family Sigma70_r4 PF04545.16 ACT00567.1 - 0.0017 17.8 0.0 0.23 11.0 0.0 2.8 2 1 1 3 3 3 1 Sigma-70, region 4 MarR_2 PF12802.7 ACT00567.1 - 0.0028 17.5 0.0 1 9.3 0.0 2.6 2 0 0 2 2 2 1 MarR family HTH_31 PF13560.6 ACT00567.1 - 0.031 14.6 0.3 9.1 6.7 0.0 3.1 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT00567.1 - 0.032 14.2 0.8 0.3 11.1 0.5 2.7 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain EutQ PF06249.12 ACT00567.1 - 0.059 13.1 0.0 0.095 12.5 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutQ MarR PF01047.22 ACT00567.1 - 0.07 13.1 0.0 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 MarR family HTH_29 PF13551.6 ACT00567.1 - 0.071 13.1 0.0 7.5 6.7 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn helix HTH_3 PF01381.22 ACT00567.1 - 0.087 12.9 0.0 1.4 9.0 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix HTH_40 PF14493.6 ACT00567.1 - 0.093 13.2 0.4 11 6.5 0.0 2.6 2 1 1 3 3 3 0 Helix-turn-helix domain GatB_Yqey PF02637.18 ACT00567.1 - 0.19 11.6 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 GatB domain Lyx_isomer PF07385.12 ACT00567.1 - 0.19 11.0 0.0 0.31 10.3 0.0 1.3 1 0 0 1 1 1 0 D-lyxose isomerase PhyH PF05721.13 ACT00568.1 - 2.2e-35 122.8 0.0 2.7e-35 122.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) MarR PF01047.22 ACT00569.1 - 8.6e-12 44.8 2.9 9.6e-11 41.5 0.2 2.8 3 1 0 3 3 3 1 MarR family MarR_2 PF12802.7 ACT00569.1 - 4.8e-10 39.2 0.9 6.1e-10 38.8 0.1 1.6 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 ACT00569.1 - 2.8e-08 34.1 0.1 1.3e-07 32.0 0.0 2.0 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_24 PF13412.6 ACT00569.1 - 0.0001 21.8 0.4 0.00031 20.3 0.1 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_34 PF13601.6 ACT00569.1 - 0.0011 19.1 0.0 0.0025 18.0 0.0 1.7 1 1 0 1 1 1 1 Winged helix DNA-binding domain Gag_p17 PF00540.18 ACT00569.1 - 0.049 13.6 0.0 0.06 13.3 0.0 1.2 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) HTH_5 PF01022.20 ACT00569.1 - 0.12 12.3 0.8 0.22 11.4 0.2 1.8 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family ABC_membrane PF00664.23 ACT00570.1 - 2.1e-43 149.0 11.4 3.2e-43 148.3 11.4 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT00570.1 - 6.7e-35 120.6 0.0 1.7e-34 119.3 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT00570.1 - 1.9e-05 24.2 1.0 0.0026 17.2 0.1 2.4 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 ACT00570.1 - 0.00059 19.6 0.0 0.0014 18.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT00570.1 - 0.00066 19.6 0.0 0.0017 18.2 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ACT00570.1 - 0.0026 18.2 0.1 0.0046 17.3 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT00570.1 - 0.0034 17.6 0.0 0.021 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 ACT00570.1 - 0.0063 17.0 0.1 0.02 15.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ACT00570.1 - 0.023 14.4 0.2 0.06 13.1 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 ACT00570.1 - 0.026 13.8 0.1 0.083 12.2 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin Peptidase_M23 PF01551.22 ACT00570.1 - 0.033 14.4 0.3 0.21 11.8 0.1 2.2 2 0 0 2 2 2 0 Peptidase family M23 AAA_18 PF13238.6 ACT00570.1 - 0.056 14.0 0.0 0.17 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ACT00570.1 - 0.075 12.7 0.0 0.6 9.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 ACT00570.1 - 0.11 12.9 0.9 1.7 9.1 0.9 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 ACT00570.1 - 0.12 12.6 0.2 3.3 8.0 0.2 2.6 2 1 0 2 2 1 0 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 ACT00570.1 - 0.13 11.8 0.5 0.29 10.7 0.1 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF1697 PF08002.11 ACT00571.1 - 3.7e-43 147.2 0.1 4.8e-43 146.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1697) adh_short_C2 PF13561.6 ACT00572.1 - 1.3e-54 185.2 0.0 1.7e-54 184.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT00572.1 - 4.1e-42 143.9 0.0 5.3e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT00572.1 - 0.0058 16.6 0.0 0.0085 16.0 0.0 1.1 1 0 0 1 1 1 1 KR domain LysR_substrate PF03466.20 ACT00574.1 - 1.6e-50 171.4 0.0 2e-50 171.1 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT00574.1 - 1.2e-21 76.4 0.0 2.3e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Mga PF05043.13 ACT00574.1 - 0.043 14.4 1.1 0.064 13.9 0.1 1.8 2 0 0 2 2 2 0 Mga helix-turn-helix domain HTH_24 PF13412.6 ACT00574.1 - 0.082 12.5 0.0 0.24 11.0 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding MarR PF01047.22 ACT00574.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 MarR family Fe_dep_repress PF01325.19 ACT00574.1 - 0.14 12.3 0.0 0.5 10.6 0.0 1.9 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain LrgA PF03788.14 ACT00575.1 - 4.4e-27 93.9 10.1 4.4e-27 93.9 10.1 1.3 1 1 0 1 1 1 1 LrgA family Rax2 PF12768.7 ACT00575.1 - 0.17 11.3 0.2 0.22 10.9 0.2 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity LrgB PF04172.16 ACT00576.1 - 2.1e-72 243.1 18.8 2.5e-72 242.9 18.8 1.0 1 0 0 1 1 1 1 LrgB-like family PAP2 PF01569.21 ACT00576.1 - 0.0049 16.6 1.3 0.0049 16.6 1.3 2.4 1 1 1 2 2 2 1 PAP2 superfamily LrgA PF03788.14 ACT00576.1 - 0.0064 16.4 1.2 0.0064 16.4 1.2 2.8 3 1 1 4 4 4 1 LrgA family EamA PF00892.20 ACT00577.1 - 1.3e-51 174.3 41.7 6.7e-29 100.8 15.6 2.0 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 ACT00577.1 - 0.4 9.8 15.8 0.53 9.4 15.8 1.2 1 0 0 1 1 1 0 Nucleotide-sugar transporter HTH_3 PF01381.22 ACT00578.1 - 2.3e-13 50.0 0.3 3.9e-13 49.2 0.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ACT00578.1 - 1.7e-12 47.5 0.0 3.6e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 ACT00578.1 - 6e-10 39.0 0.3 1.2e-09 38.0 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 ACT00578.1 - 3.5e-05 24.1 0.0 0.00011 22.6 0.0 1.8 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain Tfb4 PF03850.14 ACT00578.1 - 0.035 13.6 0.0 0.053 13.0 0.0 1.2 1 0 0 1 1 1 0 Transcription factor Tfb4 HTH_37 PF13744.6 ACT00578.1 - 0.065 13.2 0.0 0.16 12.0 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain NES_C_h PF18208.1 ACT00578.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Nicking enzyme C-terminal middle helical domain Abhydrolase_6 PF12697.7 ACT00579.1 - 8.3e-20 72.3 0.0 1e-19 72.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ACT00579.1 - 1.3e-15 57.8 0.0 1.1e-14 54.7 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ACT00579.1 - 1.4e-13 50.7 0.0 2.3e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 ACT00579.1 - 9.2e-05 21.3 0.0 0.00013 20.8 0.0 1.4 1 1 0 1 1 1 1 Ndr family Thioesterase PF00975.20 ACT00579.1 - 0.019 15.1 0.1 0.058 13.5 0.0 1.9 2 1 0 2 2 2 0 Thioesterase domain NTP_transf_2 PF01909.23 ACT00580.1 - 3.4e-10 40.1 0.0 7.6e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ACT00580.1 - 3.1e-08 33.6 0.0 6.4e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase tRNA-synt_1b PF00579.25 ACT00581.1 - 8e-57 192.8 0.0 9.8e-57 192.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.18 ACT00581.1 - 0.12 11.3 0.1 2.2 7.1 0.0 2.3 2 1 0 2 2 2 0 tRNA synthetases class I (K) Prenyltrans PF00432.21 ACT00583.1 - 0.011 15.5 0.4 4.8 7.0 0.0 2.9 3 0 0 3 3 3 0 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 ACT00583.1 - 0.083 12.0 0.0 0.69 9.0 0.0 2.1 2 0 0 2 2 2 0 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 ACT00583.1 - 0.14 11.2 0.1 15 4.6 0.0 2.1 2 0 0 2 2 2 0 Squalene-hopene cyclase C-terminal domain OmdA PF13376.6 ACT00584.1 - 1.1e-18 67.0 0.6 1.9e-18 66.2 0.6 1.4 1 0 0 1 1 1 1 Bacteriocin-protection, YdeI or OmpD-Associated DUF1801 PF08818.11 ACT00584.1 - 5.8e-14 52.4 1.3 1e-13 51.6 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DU1801) Peptidase_U57 PF05582.12 ACT00584.1 - 0.019 14.2 0.0 0.029 13.6 0.0 1.4 1 0 0 1 1 1 0 YabG peptidase U57 Putative_PNPOx PF01243.20 ACT00585.1 - 1.2e-13 51.1 0.0 1.6e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase HTH_18 PF12833.7 ACT00586.1 - 2e-23 82.5 1.1 3.1e-23 81.8 1.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00586.1 - 5.9e-20 70.9 0.1 1.6e-10 40.8 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT00586.1 - 5.6e-14 52.2 0.1 9.1e-14 51.5 0.1 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT00586.1 - 5.8e-10 38.8 0.0 1.1e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 ACT00586.1 - 0.01 15.6 0.1 0.037 13.7 0.1 2.0 1 1 0 1 1 1 0 Cupin AraC_binding_2 PF14525.6 ACT00586.1 - 0.05 13.3 0.0 0.088 12.5 0.0 1.4 1 1 0 1 1 1 0 AraC-binding-like domain MannoseP_isomer PF01050.18 ACT00586.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Glyco_hydro_31 PF01055.26 ACT00587.1 - 3e-121 405.7 2.6 3.8e-121 405.4 2.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 ACT00587.1 - 1e-17 64.2 0.1 3.5e-17 62.5 0.1 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like Glyco_hydro_3_C PF01915.22 ACT00588.1 - 6.9e-60 202.5 0.1 1.2e-59 201.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ACT00588.1 - 5.9e-44 150.7 0.0 8.7e-44 150.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ACT00588.1 - 5.7e-25 87.2 0.1 1.9e-24 85.6 0.1 2.0 1 0 0 1 1 1 1 Fibronectin type III-like domain CBM_6 PF03422.15 ACT00588.1 - 2.1e-15 57.1 0.7 1.1e-14 54.9 0.1 2.4 2 0 0 2 2 2 1 Carbohydrate binding module (family 6) His_kinase PF06580.13 ACT00589.1 - 5.9e-23 81.0 0.2 5.9e-23 81.0 0.2 2.5 2 1 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACT00589.1 - 5.4e-11 43.0 0.0 1.7e-10 41.4 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT00589.1 - 1.4e-10 41.4 0.2 5.1e-10 39.6 0.0 2.1 2 0 0 2 2 2 1 HAMP domain dCache_1 PF02743.18 ACT00589.1 - 1.9e-09 37.7 5.8 1.9e-09 37.7 5.8 2.0 2 0 0 2 2 2 1 Cache domain HATPase_c_3 PF13589.6 ACT00589.1 - 0.0087 15.9 0.0 0.022 14.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF948 PF06103.11 ACT00589.1 - 0.012 15.9 7.5 0.02 15.1 0.8 3.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) HATPase_c_2 PF13581.6 ACT00589.1 - 0.012 15.5 0.1 0.03 14.3 0.1 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Serine_rich PF08824.10 ACT00589.1 - 0.035 14.1 3.1 3.1 7.8 0.2 2.4 2 0 0 2 2 2 0 Serine rich protein interaction domain YabA PF06156.13 ACT00589.1 - 0.081 13.6 12.5 16 6.2 0.0 3.6 3 1 0 3 3 3 0 Initiation control protein YabA DUF4834 PF16118.5 ACT00589.1 - 0.33 11.9 3.9 0.9 10.5 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Response_reg PF00072.24 ACT00590.1 - 3.2e-33 114.2 0.8 6.9e-33 113.2 0.2 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00590.1 - 1.1e-18 67.3 0.0 3.3e-18 65.7 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00590.1 - 1.2e-14 53.9 0.2 3.5e-07 30.2 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT00590.1 - 0.006 16.8 0.0 0.019 15.2 0.0 1.8 1 0 0 1 1 1 1 GGDEF-like domain BPD_transp_1 PF00528.22 ACT00591.1 - 4.6e-14 52.6 13.1 4.6e-14 52.6 13.1 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Phage_holin_3_5 PF16085.5 ACT00591.1 - 2.3 8.4 6.2 0.26 11.4 0.5 2.3 3 0 0 3 3 3 0 Bacteriophage holin Hol, superfamily III MNHE PF01899.16 ACT00591.1 - 2.6 7.8 8.2 0.12 12.1 2.1 1.9 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit BPD_transp_1 PF00528.22 ACT00592.1 - 4.3e-11 42.9 28.5 6.7e-10 39.0 28.5 2.2 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_1 PF01547.25 ACT00593.1 - 1.6e-07 31.6 8.6 1.6e-07 31.6 8.6 3.5 2 2 0 2 2 2 1 Bacterial extracellular solute-binding protein Glyco_hyd_65N_2 PF14498.6 ACT00594.1 - 1.4e-59 201.9 0.0 5.5e-59 199.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, N-terminal domain His_kinase PF06580.13 ACT00596.1 - 3.7e-20 72.0 1.4 7.1e-20 71.1 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT00596.1 - 7e-09 35.8 1.4 1.2e-08 35.0 1.4 1.4 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 ACT00596.1 - 1.2e-06 28.8 0.0 2.1e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT00596.1 - 0.0044 17.5 0.0 0.011 16.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Phos_pyr_kin PF08543.12 ACT00596.1 - 0.2 11.0 0.0 0.35 10.2 0.0 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase Sigma_reg_N PF13800.6 ACT00596.1 - 1.7 9.0 4.9 5.4 7.4 0.9 2.9 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Response_reg PF00072.24 ACT00597.1 - 5.2e-23 81.4 0.1 1.3e-22 80.0 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00597.1 - 2.1e-19 69.5 0.0 5e-19 68.4 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00597.1 - 6.1e-18 64.4 0.0 1.8e-09 37.5 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Exog_C PF18026.1 ACT00597.1 - 0.079 13.0 0.5 0.31 11.1 0.0 2.2 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain SBP_bac_1 PF01547.25 ACT00598.1 - 1e-25 91.4 17.4 1.6e-25 90.8 17.4 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT00599.1 - 8e-18 64.8 21.4 8e-18 64.8 21.4 1.6 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3792 PF12670.7 ACT00599.1 - 2.3 8.4 19.3 0.22 11.7 2.2 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3792) BPD_transp_1 PF00528.22 ACT00600.1 - 3.2e-19 69.4 13.1 3.2e-19 69.4 13.1 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2621 PF11084.8 ACT00600.1 - 0.0026 17.7 3.2 0.004 17.1 0.5 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2621) PIG-P PF08510.12 ACT00600.1 - 5.3 7.0 8.2 1.4 8.9 3.6 2.2 2 0 0 2 2 2 0 PIG-P FAD_oxidored PF12831.7 ACT00601.1 - 1.6e-100 337.5 0.1 2e-100 337.2 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ACT00601.1 - 4.6e-08 32.5 2.0 9.7e-08 31.5 2.0 1.5 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 ACT00601.1 - 2.9e-07 29.9 2.0 4.7e-07 29.2 2.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 ACT00601.1 - 1.4e-06 28.4 1.6 4.9e-06 26.7 1.6 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain F5_F8_type_C PF00754.25 ACT00601.1 - 1.8e-06 28.1 0.1 0.0051 16.9 0.0 2.4 2 0 0 2 2 2 2 F5/8 type C domain Pyr_redox PF00070.27 ACT00601.1 - 3.7e-06 27.4 1.1 4.2e-05 24.0 0.4 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ACT00601.1 - 6e-06 25.7 1.6 2.3e-05 23.8 1.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT00601.1 - 8.9e-06 25.5 0.2 1.6e-05 24.7 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 ACT00601.1 - 7.1e-05 22.2 0.7 0.00015 21.1 0.7 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 ACT00601.1 - 0.0013 17.5 1.3 0.002 16.9 1.3 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 ACT00601.1 - 0.0019 17.5 0.0 0.004 16.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ACT00601.1 - 0.012 14.9 0.3 0.02 14.1 0.3 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 ACT00601.1 - 0.025 13.7 0.1 0.048 12.7 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein LPD23 PF18838.1 ACT00601.1 - 0.074 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 W_rich_C PF07483.11 ACT00601.1 - 0.097 12.8 0.1 0.44 10.7 0.0 2.2 2 0 0 2 2 2 0 Tryptophan-rich Synechocystis species C-terminal domain FAD_binding_3 PF01494.19 ACT00601.1 - 0.19 10.9 0.8 0.45 9.7 0.8 1.6 2 0 0 2 2 2 0 FAD binding domain DUF5300 PF17224.3 ACT00601.1 - 0.19 12.0 0.0 1.8 8.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5300) rve PF00665.26 ACT00602.1 - 2.3e-28 98.8 0.0 5.8e-28 97.5 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain HTH_21 PF13276.6 ACT00602.1 - 6.1e-16 58.3 2.0 1.6e-15 57.0 2.0 1.7 1 0 0 1 1 1 1 HTH-like domain rve_3 PF13683.6 ACT00602.1 - 8.6e-14 51.1 0.0 2e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 ACT00602.1 - 2.1e-11 44.2 1.3 2.7e-11 43.9 0.1 1.7 2 1 0 2 2 2 1 DDE domain rve_2 PF13333.6 ACT00602.1 - 2.4e-11 43.6 1.0 2.4e-11 43.6 1.0 1.8 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_ISAZ013 PF07592.11 ACT00602.1 - 0.023 13.7 0.0 0.041 12.9 0.0 1.3 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain HTH_Tnp_1 PF01527.20 ACT00603.1 - 4.4e-13 49.3 3.2 5.4e-13 49.1 3.2 1.1 1 0 0 1 1 1 1 Transposase HTH_Tnp_ISL3 PF13542.6 ACT00603.1 - 0.00013 21.3 0.1 0.00019 20.8 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 ACT00603.1 - 0.00054 19.7 0.1 0.001 18.8 0.1 1.5 1 1 0 1 1 1 1 Homeodomain-like domain TSC22 PF01166.18 ACT00603.1 - 0.0056 17.0 3.1 0.0083 16.4 0.6 2.1 2 0 0 2 2 2 1 TSC-22/dip/bun family DMPK_coil PF08826.10 ACT00603.1 - 0.011 15.8 1.9 0.011 15.8 1.9 1.8 2 1 0 2 2 2 0 DMPK coiled coil domain like HTH_28 PF13518.6 ACT00603.1 - 0.017 15.2 0.0 0.043 13.9 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.6 ACT00603.1 - 0.028 14.2 1.0 0.035 13.9 0.1 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_50 PF18024.1 ACT00603.1 - 0.079 12.6 0.2 0.15 11.7 0.2 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2937 PF11157.8 ACT00603.1 - 0.095 12.4 0.4 0.15 11.7 0.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) Dna2 PF08696.11 ACT00603.1 - 0.13 12.0 2.9 0.14 12.0 2.9 1.1 1 0 0 1 1 1 0 DNA replication factor Dna2 Octopine_DH PF02317.17 ACT00603.1 - 0.13 12.3 0.6 0.15 12.2 0.6 1.1 1 0 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain Cnn_1N PF07989.11 ACT00603.1 - 0.55 10.4 10.4 5.2 7.3 2.1 2.2 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DUF4140 PF13600.6 ACT00603.1 - 1.5 9.3 4.6 1.2 9.6 1.3 1.9 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Glyoxalase PF00903.25 ACT00604.1 - 1.5e-11 44.6 0.1 1.4e-10 41.4 0.1 1.9 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ACT00604.1 - 1.7e-09 37.6 0.0 2.3e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 ACT00604.1 - 0.0038 18.0 0.0 0.0056 17.4 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 ACT00604.1 - 0.0055 17.0 0.0 0.35 11.1 0.0 2.1 1 1 1 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TPP_enzyme_M PF00205.22 ACT00605.1 - 2.1e-36 124.7 0.1 4.5e-36 123.6 0.1 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 ACT00605.1 - 1.5e-35 122.2 0.1 6.5e-35 120.2 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_N PF02776.18 ACT00605.1 - 7.5e-34 116.8 0.5 7.5e-34 116.8 0.5 3.0 4 0 0 4 4 4 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain CO_dh PF02552.16 ACT00605.1 - 0.013 15.3 0.0 0.038 13.8 0.0 1.8 1 1 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit AP_endonuc_2 PF01261.24 ACT00606.1 - 2.5e-26 92.4 0.1 4.8e-26 91.5 0.1 1.4 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel PfkB PF00294.24 ACT00607.1 - 2.8e-62 210.8 0.0 3.3e-62 210.5 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase E3_UFM1_ligase PF09743.9 ACT00607.1 - 0.0098 15.5 0.0 0.013 15.2 0.0 1.1 1 0 0 1 1 1 1 E3 UFM1-protein ligase 1 Aldedh PF00171.22 ACT00608.1 - 1.7e-147 491.7 0.0 1.9e-147 491.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family GFO_IDH_MocA PF01408.22 ACT00609.1 - 6.7e-24 85.0 0.2 1.5e-23 83.9 0.2 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT00609.1 - 1.4e-07 31.5 0.0 2.7e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Gp_dh_N PF00044.24 ACT00609.1 - 4.1e-05 23.8 0.0 0.00011 22.5 0.0 1.7 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ACT00609.1 - 0.00036 21.0 0.1 0.0014 19.0 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ACT00609.1 - 0.0018 18.8 0.1 0.0054 17.3 0.1 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 ACT00609.1 - 0.026 14.6 0.0 0.098 12.8 0.0 2.1 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 ACT00609.1 - 0.043 14.1 0.2 0.16 12.3 0.1 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain 2-Hacid_dh_C PF02826.19 ACT00609.1 - 0.084 12.2 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain KduI PF04962.12 ACT00610.1 - 1.1e-111 372.3 0.0 1.3e-111 372.1 0.0 1.0 1 0 0 1 1 1 1 KduI/IolB family Peripla_BP_3 PF13377.6 ACT00611.1 - 3e-41 141.5 0.1 4.5e-40 137.7 0.1 2.2 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT00611.1 - 2.9e-35 122.1 0.0 3.9e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT00611.1 - 1.1e-22 80.9 0.0 1.9e-22 80.1 0.0 1.4 2 0 0 2 2 2 1 Periplasmic binding protein domain LacI PF00356.21 ACT00611.1 - 5.5e-20 70.9 0.1 1.4e-19 69.6 0.1 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_3 PF01381.22 ACT00611.1 - 0.0054 16.8 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix Tox-URI2 PF15653.6 ACT00611.1 - 0.027 14.7 0.1 3.3 8.0 0.0 2.4 2 0 0 2 2 2 0 URI fold toxin 2 DUF190 PF02641.15 ACT00611.1 - 0.037 14.4 0.0 0.11 12.9 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized ACR, COG1993 YdaS_antitoxin PF15943.5 ACT00611.1 - 0.047 13.6 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT KR PF08659.10 ACT00611.1 - 0.098 12.6 1.0 12 5.8 0.2 2.4 1 1 1 2 2 2 0 KR domain PucR PF07905.11 ACT00611.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family Aminotran_1_2 PF00155.21 ACT00613.1 - 4.7e-34 118.1 0.0 5.7e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II GntR PF00392.21 ACT00613.1 - 3.2e-20 71.5 0.9 5.8e-20 70.7 0.1 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Aminotran_MocR PF12897.7 ACT00613.1 - 1.9e-05 23.7 0.0 3.9e-05 22.6 0.0 1.5 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase HTH_11 PF08279.12 ACT00613.1 - 0.0008 19.3 0.1 0.0019 18.1 0.1 1.6 1 0 0 1 1 1 1 HTH domain HTH_CodY PF08222.11 ACT00613.1 - 0.0026 17.3 0.0 0.0053 16.3 0.0 1.4 1 0 0 1 1 1 1 CodY helix-turn-helix domain HTH_50 PF18024.1 ACT00613.1 - 0.0053 16.3 0.0 0.014 15.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain Rrf2 PF02082.20 ACT00613.1 - 0.0087 16.4 0.0 0.018 15.4 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator HTH_Crp_2 PF13545.6 ACT00613.1 - 0.014 15.4 0.8 0.071 13.1 0.0 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain Aminotran_5 PF00266.19 ACT00613.1 - 0.037 13.0 0.0 0.052 12.5 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class-V TrmB PF01978.19 ACT00613.1 - 0.053 13.4 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Beta_elim_lyase PF01212.21 ACT00613.1 - 0.061 12.6 0.0 0.089 12.1 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase HTH_36 PF13730.6 ACT00613.1 - 0.098 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 ACT00613.1 - 0.14 12.0 0.1 0.74 9.7 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain Rrf2 PF02082.20 ACT00614.1 - 1.6e-19 70.1 0.2 2e-19 69.7 0.2 1.2 1 0 0 1 1 1 1 Transcriptional regulator HTH_11 PF08279.12 ACT00614.1 - 0.00015 21.7 0.2 0.00025 20.9 0.2 1.4 1 0 0 1 1 1 1 HTH domain TFIIE_alpha PF02002.17 ACT00614.1 - 0.00029 20.7 0.0 0.00044 20.1 0.0 1.3 1 0 0 1 1 1 1 TFIIE alpha subunit HTH_IclR PF09339.10 ACT00614.1 - 0.00033 20.4 0.1 0.001 18.8 0.1 1.7 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR_2 PF12802.7 ACT00614.1 - 0.00037 20.3 0.1 0.00062 19.6 0.1 1.3 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 ACT00614.1 - 0.00045 20.0 0.0 0.00069 19.5 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HrcA_DNA-bdg PF03444.15 ACT00614.1 - 0.00061 19.4 0.0 0.0009 18.8 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding MarR PF01047.22 ACT00614.1 - 0.0013 18.6 0.1 0.003 17.5 0.1 1.6 1 0 0 1 1 1 1 MarR family GntR PF00392.21 ACT00614.1 - 0.0024 17.5 0.1 0.0054 16.3 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_20 PF12840.7 ACT00614.1 - 0.0037 17.3 0.1 0.0063 16.5 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT00614.1 - 0.0045 16.9 0.1 0.0075 16.2 0.1 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 ACT00614.1 - 0.015 14.9 0.2 0.027 14.1 0.2 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_29 PF13551.6 ACT00614.1 - 0.023 14.7 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Mga PF08280.11 ACT00614.1 - 0.023 14.7 0.1 0.73 9.9 0.1 2.1 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_23 PF13384.6 ACT00614.1 - 0.027 14.3 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DUF742 PF05331.11 ACT00614.1 - 0.041 13.7 0.0 0.059 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF742) GST_C PF00043.25 ACT00614.1 - 0.051 13.8 0.0 0.096 12.9 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ANAPC2 PF08672.11 ACT00614.1 - 0.092 13.3 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 Anaphase promoting complex (APC) subunit 2 HTH_47 PF16221.5 ACT00614.1 - 0.12 11.9 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 winged helix-turn-helix DUF410 PF04190.13 ACT00614.1 - 0.14 11.9 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF410) FeoC PF09012.10 ACT00614.1 - 0.17 12.0 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 FeoC like transcriptional regulator Lactamase_B_3 PF13483.6 ACT00615.1 - 2.4e-45 154.4 0.2 2.8e-45 154.1 0.2 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 ACT00615.1 - 1.1e-11 44.6 1.2 2.9e-07 30.2 0.1 2.1 1 1 1 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACT00615.1 - 0.23 11.4 3.6 2.3 8.2 1.9 2.4 2 1 0 2 2 2 0 Metallo-beta-lactamase superfamily AbrB PF05145.12 ACT00616.1 - 3.5e-84 282.4 36.0 2.1e-82 276.6 28.4 1.9 1 1 1 2 2 2 2 Transition state regulatory protein AbrB Lung_7-TM_R PF06814.13 ACT00616.1 - 0.032 13.5 1.3 0.059 12.6 1.3 1.4 1 0 0 1 1 1 0 Lung seven transmembrane receptor Epimerase PF01370.21 ACT00617.1 - 7.4e-22 78.0 0.0 1.1e-21 77.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ACT00617.1 - 4.2e-15 56.1 0.1 4.9e-15 55.9 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT00617.1 - 1.2e-10 41.4 0.1 1.7e-10 40.9 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 ACT00617.1 - 7.5e-10 38.4 0.0 1e-09 38.0 0.0 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ACT00617.1 - 1.2e-09 37.7 0.0 1.8e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ACT00617.1 - 2.1e-08 33.6 0.0 2.9e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 ACT00617.1 - 4.1e-08 33.0 0.0 2.5e-07 30.4 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase ApbA PF02558.16 ACT00617.1 - 3.5e-05 23.5 0.0 5.2e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 ACT00617.1 - 0.0068 16.7 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain DapB_N PF01113.20 ACT00617.1 - 0.011 15.8 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ADH_zinc_N PF00107.26 ACT00617.1 - 0.018 15.0 0.0 0.031 14.3 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase NAD_binding_2 PF03446.15 ACT00617.1 - 0.08 13.1 0.0 0.14 12.3 0.0 1.4 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.14 ACT00617.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glyco_transf_4 PF13439.6 ACT00617.1 - 0.14 12.1 0.1 0.39 10.7 0.1 1.7 1 1 0 1 1 1 0 Glycosyltransferase Family 4 SLH PF00395.20 ACT00618.1 - 1.1e-43 147.0 6.4 1.9e-14 53.4 1.2 3.8 3 0 0 3 3 3 3 S-layer homology domain DUF5011 PF16403.5 ACT00618.1 - 3e-42 142.6 19.7 1.1e-23 83.1 4.9 3.6 2 0 0 2 2 2 2 Domain of unknown function (DUF5011) F5_F8_type_C PF00754.25 ACT00618.1 - 3.1e-16 59.6 3.3 3.1e-16 59.6 3.3 3.4 3 1 0 3 3 3 1 F5/8 type C domain Cadherin-like PF12733.7 ACT00618.1 - 4.2e-10 40.0 0.2 4.2e-10 40.0 0.2 5.3 6 1 1 7 7 6 1 Cadherin-like beta sandwich domain fn3 PF00041.21 ACT00618.1 - 3.7e-06 27.2 4.2 4e-06 27.1 0.5 3.1 3 1 0 3 3 3 1 Fibronectin type III domain HYR PF02494.16 ACT00618.1 - 0.0016 18.7 13.0 0.24 11.8 0.9 4.3 3 0 0 3 3 3 2 HYR domain Big_3 PF07523.12 ACT00618.1 - 0.0072 16.6 3.9 0.0072 16.6 3.9 4.1 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 3) Big_3_3 PF13750.6 ACT00618.1 - 0.021 14.5 11.2 0.11 12.2 0.0 5.1 5 1 1 6 6 6 0 Bacterial Ig-like domain (group 3) RGI_lyase PF18370.1 ACT00618.1 - 0.023 15.0 0.1 0.023 15.0 0.1 3.0 3 0 0 3 3 3 0 Rhamnogalacturonan I lyases beta-sheet domain DUF4625 PF15418.6 ACT00618.1 - 1.2 9.4 3.1 6.3 7.0 0.2 3.5 3 2 0 4 4 4 0 Domain of unknown function (DUF4625) CopC PF04234.12 ACT00618.1 - 2.2 9.4 9.7 2 9.5 0.6 4.1 4 0 0 4 4 4 0 CopC domain Cadherin PF00028.17 ACT00618.1 - 4.9 7.7 8.2 11 6.5 0.4 4.6 4 1 1 5 5 4 0 Cadherin domain AHSA1 PF08327.11 ACT00619.1 - 2.4e-06 27.8 0.0 2.6e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ACT00619.1 - 0.0024 18.1 0.0 0.003 17.8 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Baculo_gp41 PF04700.12 ACT00620.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region TRAP_beta PF05753.14 ACT00622.1 - 0.023 14.1 0.4 0.023 14.1 0.4 1.0 1 0 0 1 1 1 0 Translocon-associated protein beta (TRAPB) GerA PF03323.13 ACT00623.1 - 7.7e-186 618.1 0.2 8.7e-186 617.9 0.2 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Diphthami_syn_2 PF01902.17 ACT00623.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Diphthamide synthase Spore_GerAC PF05504.11 ACT00624.1 - 2.5e-35 122.1 0.0 3.6e-35 121.6 0.0 1.2 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal LytR_cpsA_psr PF03816.14 ACT00624.1 - 0.012 15.8 0.0 0.021 15.0 0.0 1.3 1 0 0 1 1 1 0 Cell envelope-related transcriptional attenuator domain Nucleolin_bd PF16725.5 ACT00624.1 - 0.17 11.6 0.1 0.29 10.8 0.1 1.4 1 0 0 1 1 1 0 Nucleolin binding domain Spore_permease PF03845.13 ACT00625.1 - 5.5e-37 127.3 25.4 7.1e-37 126.9 25.4 1.1 1 0 0 1 1 1 1 Spore germination protein Pentapeptide PF00805.22 ACT00626.1 - 2.9e-31 106.7 18.3 2.5e-13 49.4 1.1 5.7 4 2 2 6 6 6 5 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ACT00626.1 - 4.3e-31 106.9 16.4 4.4e-09 36.4 0.1 3.5 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ACT00626.1 - 8.7e-17 61.0 7.5 2.1e-06 27.8 1.9 4.6 2 2 2 4 4 4 4 Pentapeptide repeats (9 copies) CfAFP PF05264.11 ACT00626.1 - 0.086 12.8 0.1 5.8 6.9 0.1 2.6 1 1 1 2 2 2 0 Choristoneura fumiferana antifreeze protein (CfAFP) PD40 PF07676.12 ACT00627.1 - 3.2e-27 93.9 12.4 1e-07 31.7 0.0 6.3 6 1 0 6 6 6 5 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ACT00627.1 - 1e-07 31.1 0.0 0.033 12.9 0.0 4.4 2 1 3 5 5 5 3 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5050 PF16472.5 ACT00627.1 - 0.024 13.9 0.0 0.046 13.0 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5050) Inhibitor_I42 PF09394.10 ACT00627.1 - 0.096 13.1 0.0 0.3 11.5 0.0 1.8 2 0 0 2 2 2 0 Chagasin family peptidase inhibitor I42 Proteasome_A_N PF10584.9 ACT00627.1 - 3.5 7.4 5.5 44 3.9 0.0 4.2 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature LysR_substrate PF03466.20 ACT00628.1 - 3.7e-46 157.1 0.3 5.4e-46 156.6 0.0 1.4 2 0 0 2 2 2 1 LysR substrate binding domain HTH_1 PF00126.27 ACT00628.1 - 2.3e-16 59.5 0.5 4.2e-16 58.6 0.5 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 ACT00628.1 - 2.3e-05 24.2 0.1 5.4e-05 23.0 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACT00628.1 - 3e-05 24.0 0.3 9.4e-05 22.4 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_IclR PF09339.10 ACT00628.1 - 0.0023 17.7 0.5 0.0059 16.4 0.4 1.8 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR_2 PF12802.7 ACT00628.1 - 0.0033 17.3 0.2 0.032 14.1 0.1 2.5 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.6 ACT00628.1 - 0.0083 15.7 0.0 0.017 14.7 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 ACT00628.1 - 0.03 14.4 0.0 0.057 13.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_10 PF04967.12 ACT00628.1 - 0.039 13.8 0.2 0.099 12.5 0.1 1.8 2 0 0 2 2 2 0 HTH DNA binding domain GerE PF00196.19 ACT00628.1 - 0.054 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family SBP_bac_6 PF13343.6 ACT00629.1 - 9.5e-32 110.3 5.2 1.6e-31 109.6 5.2 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT00629.1 - 1.7e-29 103.6 11.3 1.7e-29 103.6 11.3 1.6 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT00629.1 - 4e-25 88.9 2.6 4e-25 88.9 2.6 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT00629.1 - 5.7e-18 65.9 14.8 9.1e-18 65.3 14.8 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein LPAM_2 PF13627.6 ACT00629.1 - 0.068 13.0 0.5 0.12 12.2 0.5 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site BPD_transp_1 PF00528.22 ACT00630.1 - 1.3e-21 77.2 44.4 7.2e-14 51.9 17.8 3.4 3 1 1 4 4 4 2 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 ACT00631.1 - 1.3e-37 129.4 0.0 2.2e-37 128.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00631.1 - 7.4e-09 35.8 0.2 0.004 17.0 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ACT00631.1 - 9.8e-05 22.3 0.2 0.00025 21.0 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ACT00631.1 - 0.00016 22.1 0.1 0.00053 20.4 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT00631.1 - 0.0029 17.9 0.1 0.01 16.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ACT00631.1 - 0.0067 16.9 0.2 0.011 16.2 0.2 1.3 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 ACT00631.1 - 0.0084 15.6 0.1 0.1 12.0 0.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT00631.1 - 0.0086 15.8 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad17 PF03215.15 ACT00631.1 - 0.013 15.4 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_33 PF13671.6 ACT00631.1 - 0.026 14.7 0.1 0.16 12.1 0.1 2.1 1 1 0 1 1 1 0 AAA domain TOBE_2 PF08402.10 ACT00631.1 - 0.037 14.2 0.0 0.21 11.8 0.0 2.3 1 1 1 2 2 2 0 TOBE domain NACHT PF05729.12 ACT00631.1 - 0.057 13.3 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 ACT00631.1 - 0.066 12.4 0.1 0.31 10.2 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.29 ACT00631.1 - 0.082 13.3 0.0 0.28 11.6 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ACT00631.1 - 0.099 12.5 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PRK PF00485.18 ACT00631.1 - 0.18 11.6 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.6 ACT00631.1 - 0.21 11.6 0.0 0.46 10.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Bee_toxin PF17454.2 ACT00634.1 - 0.13 12.3 3.4 6.1 7.0 0.2 2.3 2 1 0 2 2 2 0 Honey bee toxin Cupin_1 PF00190.22 ACT00638.1 - 1.9e-13 50.3 0.1 2.5e-13 49.9 0.1 1.2 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 ACT00638.1 - 0.00016 21.3 0.0 0.0003 20.4 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ACT00639.1 - 4.9e-43 146.3 0.0 1.9e-22 79.5 0.0 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 ACT00639.1 - 7.5e-24 83.2 0.3 1.3e-11 44.1 0.0 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 ACT00639.1 - 5.7e-08 32.3 0.1 0.0022 17.7 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 ACT00639.1 - 0.014 15.3 1.4 0.12 12.2 0.1 2.4 3 0 0 3 3 3 0 AraC-like ligand binding domain ARD PF03079.14 ACT00639.1 - 0.023 14.9 0.2 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 ARD/ARD' family MannoseP_isomer PF01050.18 ACT00639.1 - 0.031 14.2 0.0 0.35 10.7 0.0 2.1 2 0 0 2 2 2 0 Mannose-6-phosphate isomerase 3-HAO PF06052.12 ACT00639.1 - 0.054 13.1 0.0 0.45 10.1 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase 2OG-FeII_Oxy_5 PF13759.6 ACT00639.1 - 0.082 13.3 0.0 0.63 10.5 0.0 2.3 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase Pirin PF02678.16 ACT00640.1 - 1.8e-29 101.8 0.4 3.1e-29 101.1 0.4 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 ACT00640.1 - 3.5e-25 88.4 0.0 5.4e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 Pirin C-terminal cupin domain FimA PF16970.5 ACT00640.1 - 0.1 12.8 0.2 0.16 12.1 0.2 1.3 1 0 0 1 1 1 0 Type-1 fimbrial protein, A Pirin_C_2 PF17954.1 ACT00640.1 - 0.16 12.1 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Quercetinase C-terminal cupin domain Hepar_II_III PF07940.13 ACT00641.1 - 9.9e-09 35.2 0.0 1.9e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Heparinase II/III-like protein Hepar_II_III_N PF16889.5 ACT00641.1 - 0.00036 19.9 0.1 0.00061 19.2 0.1 1.4 1 0 0 1 1 1 1 Heparinase II/III N-terminus Glyco_hydro_88 PF07470.13 ACT00642.1 - 9.1e-23 80.9 2.5 1.2e-22 80.5 2.5 1.1 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 ACT00642.1 - 0.011 15.2 0.0 0.053 13.0 0.0 2.1 3 0 0 3 3 3 0 D-glucuronyl C5-epimerase C-terminus HTH_18 PF12833.7 ACT00643.1 - 3.4e-16 59.3 0.1 6.3e-16 58.4 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00643.1 - 3.5e-12 46.1 0.6 9e-10 38.4 0.1 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT00643.1 - 0.011 15.4 0.2 0.026 14.3 0.2 1.6 1 0 0 1 1 1 0 Cupin domain Glyco_hydro_127 PF07944.12 ACT00644.1 - 9.8e-112 374.1 0.4 4.5e-111 371.9 0.4 1.8 1 1 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 PilX PF13681.6 ACT00644.1 - 0.039 14.3 0.0 0.095 13.1 0.0 1.6 1 0 0 1 1 1 0 Type IV pilus assembly protein PilX C-term DUF4962 PF16332.5 ACT00645.1 - 0.00013 20.6 0.9 0.00018 20.2 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4962) NPCBM PF08305.11 ACT00645.1 - 0.012 15.8 0.3 2.8 8.1 0.0 3.3 3 0 0 3 3 3 0 NPCBM/NEW2 domain dCache_1 PF02743.18 ACT00646.1 - 3.6e-29 102.3 1.1 3.6e-29 102.3 1.1 1.5 2 0 0 2 2 2 1 Cache domain His_kinase PF06580.13 ACT00646.1 - 3.6e-22 78.5 2.7 7.2e-22 77.5 0.4 2.3 2 0 0 2 2 2 1 Histidine kinase HAMP PF00672.25 ACT00646.1 - 5.1e-10 39.6 0.1 1.7e-08 34.7 0.0 2.8 2 0 0 2 2 2 1 HAMP domain HATPase_c PF02518.26 ACT00646.1 - 7.1e-08 32.9 0.2 1.5e-06 28.7 0.0 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT00646.1 - 0.013 15.3 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ACT00647.1 - 1e-27 96.5 0.0 2.1e-27 95.5 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00647.1 - 8.5e-21 74.0 0.4 3.2e-20 72.2 0.2 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00647.1 - 5e-12 45.6 0.4 2.4e-06 27.5 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT00647.1 - 0.0019 18.5 0.0 0.0056 16.9 0.0 1.9 1 0 0 1 1 1 1 GGDEF-like domain DUF4404 PF14357.6 ACT00647.1 - 0.062 13.9 0.5 20 5.9 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Amdase PF17645.1 ACT00647.1 - 0.091 12.4 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 Arylmalonate decarboxylase SBP_bac_1 PF01547.25 ACT00648.1 - 1e-26 94.7 0.6 1.5e-26 94.1 0.6 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT00648.1 - 3.6e-23 82.8 0.1 4.8e-23 82.4 0.1 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT00649.1 - 5.2e-24 85.3 0.1 2.8e-23 83.0 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) SBP_bac_8 PF13416.6 ACT00649.1 - 3.9e-13 49.8 0.1 5.4e-13 49.4 0.1 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT00649.1 - 1.3e-12 48.3 0.2 9.9e-12 45.4 0.2 2.1 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein Alginate_lyase PF05426.12 ACT00650.1 - 7.4e-05 22.4 5.2 0.016 14.8 0.6 2.5 2 0 0 2 2 2 2 Alginate lyase BPD_transp_1 PF00528.22 ACT00651.1 - 2.8e-16 59.8 20.4 2.8e-16 59.8 20.4 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00652.1 - 1.7e-12 47.5 20.4 1.5e-11 44.4 20.4 2.1 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF3792 PF12670.7 ACT00652.1 - 0.4 10.9 12.5 3 8.0 4.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3792) DUF3502 PF12010.8 ACT00653.1 - 1.1e-24 87.5 2.6 1.1e-24 87.5 2.6 2.4 2 1 1 3 3 3 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACT00653.1 - 1.4e-11 44.9 15.1 3.8e-11 43.5 15.1 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3597 PF12200.8 ACT00653.1 - 0.093 13.3 0.9 0.23 12.0 0.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) DUF4969 PF16339.5 ACT00653.1 - 0.1 12.9 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4969) SLH PF00395.20 ACT00654.1 - 9.9e-36 121.5 0.3 2.6e-15 56.1 0.1 4.0 3 0 0 3 3 3 3 S-layer homology domain Hepar_II_III PF07940.13 ACT00654.1 - 2.1e-12 47.2 0.0 5.7e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 Heparinase II/III-like protein CBM_4_9 PF02018.17 ACT00654.1 - 0.00053 20.3 1.4 0.0022 18.3 0.1 2.8 2 0 0 2 2 2 1 Carbohydrate binding domain Malt_amylase_C PF16657.5 ACT00654.1 - 0.023 14.8 0.2 0.2 11.8 0.0 2.7 2 0 0 2 2 2 0 Maltogenic Amylase, C-terminal domain Glyco_hydro_30C PF17189.4 ACT00654.1 - 0.063 13.5 0.7 0.45 10.8 0.5 2.6 2 0 0 2 2 2 0 Glycosyl hydrolase family 30 beta sandwich domain Abhydrolase_7 PF12715.7 ACT00655.1 - 7.5e-13 48.5 0.0 4.9e-12 45.8 0.0 1.9 1 1 0 1 1 1 1 Abhydrolase family AXE1 PF05448.12 ACT00655.1 - 1.5e-07 30.4 0.0 6.5e-06 25.0 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) DLH PF01738.18 ACT00655.1 - 1.1e-06 28.3 0.0 2e-06 27.5 0.0 1.6 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 ACT00655.1 - 0.00036 20.1 0.1 0.0022 17.5 0.0 2.3 2 1 0 2 2 2 1 Prolyl oligopeptidase family BAAT_C PF08840.11 ACT00655.1 - 0.014 15.4 0.0 0.039 13.9 0.0 1.7 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 ACT00655.1 - 0.083 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) SLH PF00395.20 ACT00656.1 - 9.3e-29 99.2 1.9 1.3e-10 41.1 0.0 3.9 3 0 0 3 3 3 3 S-layer homology domain Cohesin PF00963.18 ACT00656.1 - 1.7e-07 31.6 0.3 5.4e-07 29.9 0.3 1.9 1 0 0 1 1 1 1 Cohesin domain GIT1_C PF12205.8 ACT00656.1 - 0.16 12.0 0.2 0.35 11.0 0.2 1.5 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term Glyco_hydro_3 PF00933.21 ACT00657.1 - 4.5e-37 128.1 0.0 7.8e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Cohesin PF00963.18 ACT00657.1 - 1e-22 80.9 3.6 2.4e-22 79.7 3.6 1.7 1 0 0 1 1 1 1 Cohesin domain Glyco_hydro_3_C PF01915.22 ACT00657.1 - 6.1e-19 68.8 1.8 9.8e-19 68.1 1.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Dockerin_1 PF00404.18 ACT00657.1 - 8.9e-09 35.4 0.8 1.4e-07 31.5 0.6 2.8 2 0 0 2 2 2 1 Dockerin type I domain EF-hand_1 PF00036.32 ACT00657.1 - 0.016 14.7 1.6 12 5.8 0.1 3.6 3 0 0 3 3 3 0 EF hand EF-hand_5 PF13202.6 ACT00657.1 - 0.09 12.3 6.4 4.8 6.8 0.9 3.6 3 0 0 3 3 3 0 EF hand EF-hand_6 PF13405.6 ACT00657.1 - 0.4 10.7 1.7 86 3.5 0.1 3.6 3 0 0 3 3 3 0 EF-hand domain VCBS PF13517.6 ACT00657.1 - 1.4 9.6 5.1 87 3.8 0.0 3.9 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella dCache_1 PF02743.18 ACT00658.1 - 5.8e-10 39.4 3.0 7.5e-10 39.0 3.0 1.1 1 0 0 1 1 1 1 Cache domain O-ag_pol_Wzy PF14296.6 ACT00658.1 - 0.021 13.5 5.7 0.027 13.1 5.7 1.1 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy WAC_Acf1_DNA_bd PF10537.9 ACT00658.1 - 0.024 15.2 1.3 0.78 10.3 0.1 2.3 2 0 0 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal His_kinase PF06580.13 ACT00659.1 - 1.4e-24 86.2 1.4 3.2e-24 85.0 1.4 1.6 1 0 0 1 1 1 1 Histidine kinase HATPase_c PF02518.26 ACT00659.1 - 1.9e-09 38.0 0.2 4.4e-09 36.8 0.2 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT00659.1 - 5.5e-08 33.1 0.2 2.8e-07 30.8 0.0 2.2 3 0 0 3 3 3 1 HAMP domain HATPase_c_3 PF13589.6 ACT00659.1 - 0.00013 21.8 0.0 0.00027 20.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT00659.1 - 0.0058 16.5 0.1 0.027 14.4 0.1 2.1 1 1 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 ACT00659.1 - 0.008 16.1 0.0 0.023 14.7 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain Filament PF00038.21 ACT00659.1 - 0.022 14.3 4.3 0.036 13.7 4.3 1.2 1 0 0 1 1 1 0 Intermediate filament protein Response_reg PF00072.24 ACT00660.1 - 7.7e-23 80.8 0.0 1.7e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00660.1 - 7e-21 74.3 0.0 1.7e-20 73.1 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00660.1 - 9.6e-19 67.0 0.2 1.7e-08 34.4 0.0 2.9 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT00660.1 - 5.4e-10 39.5 0.0 5.1e-08 33.2 0.0 2.6 3 0 0 3 3 3 1 GGDEF-like domain ANTAR PF03861.14 ACT00660.1 - 0.054 13.3 0.5 0.22 11.4 0.1 2.3 2 0 0 2 2 2 0 ANTAR domain Nuf2 PF03800.14 ACT00660.1 - 0.08 13.1 0.2 0.24 11.5 0.2 1.8 1 0 0 1 1 1 0 Nuf2 family SBP_bac_1 PF01547.25 ACT00661.1 - 2.6e-35 122.9 7.5 4.1e-35 122.2 7.5 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT00661.1 - 2.4e-30 106.3 5.3 2.4e-30 106.3 5.3 1.4 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein DUF3316 PF11777.8 ACT00661.1 - 0.093 12.8 0.3 0.18 11.8 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3316) YjbE PF11106.8 ACT00661.1 - 0.65 10.2 4.1 0.47 10.7 2.2 1.7 1 1 0 1 1 1 0 Exopolysaccharide production protein YjbE DUF3827 PF12877.7 ACT00661.1 - 0.78 8.0 2.2 0.43 8.9 0.3 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3827) BPD_transp_1 PF00528.22 ACT00662.1 - 8.5e-16 58.2 17.0 8.5e-16 58.2 17.0 1.9 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00663.1 - 1.4e-09 38.0 29.3 2.4e-07 30.7 29.3 2.3 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component PEP-utilizers_C PF02896.18 ACT00664.1 - 1.7e-115 385.2 0.0 2.5e-115 384.6 0.0 1.2 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PEP-utilisers_N PF05524.13 ACT00664.1 - 6.8e-30 103.6 8.8 6.8e-30 103.6 8.8 2.0 2 0 0 2 2 2 1 PEP-utilising enzyme, N-terminal PEP-utilizers PF00391.23 ACT00664.1 - 1.1e-23 82.7 0.6 2.7e-23 81.5 0.6 1.7 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain HpcH_HpaI PF03328.14 ACT00664.1 - 0.00018 20.7 0.0 0.00043 19.5 0.0 1.6 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PTS-HPr PF00381.19 ACT00665.1 - 7.8e-24 83.7 1.4 8.5e-24 83.6 1.4 1.0 1 0 0 1 1 1 1 PTS HPr component phosphorylation site PTS_EIIC PF02378.18 ACT00666.1 - 1.1e-80 271.1 34.6 1.7e-80 270.5 34.6 1.3 1 0 0 1 1 1 1 Phosphotransferase system, EIIC PTS_EIIB PF00367.20 ACT00666.1 - 2.1e-14 52.7 0.1 3.6e-14 51.9 0.1 1.4 1 0 0 1 1 1 1 phosphotransferase system, EIIB NADH5_C PF06455.11 ACT00666.1 - 0.48 10.0 4.7 0.31 10.6 0.8 2.2 2 0 0 2 2 2 0 NADH dehydrogenase subunit 5 C-terminus PTS_EIIA_1 PF00358.20 ACT00667.1 - 5.3e-49 165.2 0.1 6.6e-49 164.9 0.1 1.1 1 0 0 1 1 1 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Biotin_lipoyl PF00364.22 ACT00667.1 - 0.0034 17.2 0.0 0.031 14.1 0.0 2.4 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 ACT00667.1 - 0.0092 15.8 1.4 4.4 7.2 0.0 3.0 4 0 0 4 4 4 2 Biotin-lipoyl like Peptidase_M23 PF01551.22 ACT00667.1 - 0.03 14.5 0.1 0.085 13.1 0.1 1.8 2 1 0 2 2 2 0 Peptidase family M23 PRD PF00874.20 ACT00668.1 - 3.1e-47 158.8 1.9 2.1e-24 85.6 0.0 2.2 2 0 0 2 2 2 2 PRD domain CAT_RBD PF03123.15 ACT00668.1 - 2.4e-14 53.0 0.0 4.8e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 CAT RNA binding domain PP-binding PF00550.25 ACT00668.1 - 0.033 14.5 0.3 28 5.1 0.0 3.4 4 0 0 4 4 4 0 Phosphopantetheine attachment site Glyco_tranf_2_4 PF13704.6 ACT00669.1 - 1.2e-10 41.7 0.0 2.1e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Epimerase PF01370.21 ACT00670.1 - 4.2e-31 108.3 0.0 5.2e-31 108.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACT00670.1 - 2.9e-21 76.2 0.0 4.3e-20 72.4 0.0 2.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ACT00670.1 - 2.8e-05 23.4 0.0 4.2e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ACT00670.1 - 6.4e-05 22.9 0.0 0.00027 20.9 0.0 2.0 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT00670.1 - 0.00017 21.2 0.1 0.00026 20.6 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ACT00670.1 - 0.057 12.9 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 short chain dehydrogenase NAD_binding_4 PF07993.12 ACT00670.1 - 0.078 12.1 0.1 0.11 11.6 0.1 1.2 1 0 0 1 1 1 0 Male sterility protein DapB_N PF01113.20 ACT00670.1 - 0.11 12.6 0.1 0.3 11.2 0.0 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.19 ACT00670.1 - 0.21 10.6 0.0 1 8.3 0.0 1.9 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Bac_luciferase PF00296.20 ACT00671.1 - 9.7e-54 182.9 0.5 1.2e-53 182.6 0.5 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase EamA PF00892.20 ACT00672.1 - 1.2e-30 106.5 34.3 5e-16 59.1 16.3 2.0 2 0 0 2 2 2 2 EamA-like transporter family Tmemb_14 PF03647.13 ACT00672.1 - 5.5 7.8 13.0 1.2 9.9 6.9 2.7 1 1 1 2 2 2 0 Transmembrane proteins 14C GFO_IDH_MocA PF01408.22 ACT00673.1 - 1.2e-26 93.9 0.0 1.6e-26 93.4 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ACT00673.1 - 1.5e-06 28.8 0.0 2.3e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ACT00673.1 - 9.3e-06 26.1 0.0 1.9e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 ACT00673.1 - 9.1e-05 22.5 0.0 0.00015 21.9 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 ACT00673.1 - 0.0069 16.8 0.0 0.013 15.9 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain CoA_binding PF02629.19 ACT00673.1 - 0.021 15.5 0.0 0.043 14.5 0.0 1.5 1 0 0 1 1 1 0 CoA binding domain 2-Hacid_dh_C PF02826.19 ACT00673.1 - 0.086 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ACT00673.1 - 0.11 12.7 0.1 0.41 10.9 0.1 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GFO_IDH_MocA_C PF02894.17 ACT00673.1 - 0.13 12.2 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain NUDIX PF00293.28 ACT00674.1 - 9.8e-16 58.0 0.0 1.3e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Nudix_N_2 PF14803.6 ACT00674.1 - 6.9e-06 25.9 0.7 1.3e-05 25.0 0.7 1.4 1 0 0 1 1 1 1 Nudix N-terminal DZR PF12773.7 ACT00674.1 - 0.026 14.5 0.6 0.045 13.8 0.6 1.3 1 0 0 1 1 1 0 Double zinc ribbon RNHCP PF12647.7 ACT00674.1 - 0.036 14.0 0.1 0.057 13.4 0.1 1.3 1 0 0 1 1 1 0 RNHCP domain Ribosomal_S5_C PF03719.15 ACT00674.1 - 0.1 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S5, C-terminal domain RNA_POL_M_15KD PF02150.16 ACT00674.1 - 0.1 12.5 0.8 0.19 11.6 0.8 1.5 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit Zn-ribbon_8 PF09723.10 ACT00674.1 - 0.13 12.4 1.4 0.39 10.9 1.4 1.7 1 0 0 1 1 1 0 Zinc ribbon domain Pribosyltran_N PF13793.6 ACT00675.1 - 8.3e-46 154.7 0.2 3.3e-45 152.8 0.1 2.0 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 ACT00675.1 - 1.4e-19 70.8 0.6 3.3e-19 69.6 0.4 1.6 1 1 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 ACT00675.1 - 4.6e-18 65.2 0.2 4.8e-16 58.7 0.1 2.8 3 0 0 3 3 3 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ACT00675.1 - 1.9e-05 24.2 0.1 3.2e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pox_I6 PF04595.13 ACT00675.1 - 0.012 14.5 0.1 0.018 14.1 0.1 1.4 1 0 0 1 1 1 0 Poxvirus I6-like family SBP_bac_8 PF13416.6 ACT00676.1 - 2.5e-44 152.2 14.1 2.5e-44 152.2 14.1 1.7 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT00676.1 - 8.4e-34 117.9 14.5 1.3e-33 117.4 14.5 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT00676.1 - 6.1e-07 29.4 0.1 7.8e-06 25.8 0.1 2.2 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT00676.1 - 0.00014 21.3 0.1 0.077 12.4 0.0 2.5 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein Secretin_N_2 PF07655.13 ACT00676.1 - 0.3 11.7 3.1 0.96 10.0 0.9 2.6 3 0 0 3 3 3 0 Secretin N-terminal domain BPD_transp_1 PF00528.22 ACT00677.1 - 4.9e-14 52.5 18.5 4.9e-14 52.5 18.5 2.2 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00678.1 - 9.7e-21 74.3 17.6 9.7e-21 74.3 17.6 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component His_kinase PF06580.13 ACT00679.1 - 1.8e-22 79.4 2.3 5.1e-22 78.0 2.3 1.8 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACT00679.1 - 7.8e-14 51.8 0.0 1.9e-13 50.6 0.0 1.7 1 0 0 1 1 1 1 HAMP domain dCache_1 PF02743.18 ACT00679.1 - 9.6e-11 41.9 2.8 2e-10 40.9 2.8 1.5 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT00679.1 - 1.9e-06 28.4 0.0 3.5e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT00679.1 - 0.022 14.6 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2280 PF10045.9 ACT00679.1 - 0.039 14.2 0.1 3.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2280) Sulfate_transp PF00916.20 ACT00679.1 - 1.8 7.3 7.0 1.1 8.0 0.2 2.7 3 0 0 3 3 3 0 Sulfate permease family Response_reg PF00072.24 ACT00680.1 - 3.7e-27 94.7 0.1 7.9e-27 93.7 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT00680.1 - 8.7e-21 74.0 0.0 2.4e-20 72.6 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT00680.1 - 1.4e-18 66.5 0.1 3.1e-10 39.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT00680.1 - 0.0015 18.8 0.0 0.0061 16.8 0.0 2.0 1 0 0 1 1 1 1 GGDEF-like domain HTH_24 PF13412.6 ACT00680.1 - 0.003 17.1 0.0 2 8.1 0.0 2.7 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding Sigma70_r4 PF04545.16 ACT00680.1 - 0.0037 16.7 0.3 0.014 14.9 0.3 2.0 1 0 0 1 1 1 1 Sigma-70, region 4 DUF3966 PF13110.6 ACT00680.1 - 0.061 13.2 0.3 3.5 7.6 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3966) HTH_Crp_2 PF13545.6 ACT00680.1 - 0.079 12.9 0.0 0.63 10.1 0.0 2.6 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain adh_short PF00106.25 ACT00681.1 - 8.4e-45 152.6 0.1 1.1e-44 152.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT00681.1 - 6.6e-24 84.8 0.1 8.8e-24 84.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT00681.1 - 2.1e-06 27.7 0.1 3.2e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACT00681.1 - 0.0022 17.5 0.0 0.012 15.1 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family MerR_1 PF13411.6 ACT00682.1 - 7.6e-17 61.2 0.0 1.2e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT00682.1 - 2.2e-14 52.9 0.1 3.4e-14 52.3 0.1 1.3 1 0 0 1 1 1 1 MerR family regulatory protein HTH_17 PF12728.7 ACT00682.1 - 0.00045 20.4 0.1 0.00097 19.3 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain NUMOD1 PF07453.13 ACT00682.1 - 0.026 14.8 0.1 0.047 14.0 0.1 1.5 1 0 0 1 1 1 0 NUMOD1 domain Sigma70_r4 PF04545.16 ACT00682.1 - 0.035 13.6 0.0 0.07 12.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_23 PF13384.6 ACT00682.1 - 0.087 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_3 PF01381.22 ACT00682.1 - 0.11 12.6 0.1 0.32 11.1 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix Acetyltransf_1 PF00583.25 ACT00683.1 - 1.6e-08 34.7 0.3 2.1e-08 34.4 0.3 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT00683.1 - 4.5e-08 33.1 0.1 5.8e-08 32.7 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT00683.1 - 2.4e-07 31.1 0.5 3.6e-07 30.5 0.5 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT00683.1 - 4.2e-06 26.9 0.1 5.6e-06 26.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ACT00683.1 - 0.0046 16.9 0.0 0.0082 16.1 0.0 1.3 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 ACT00683.1 - 0.043 13.3 0.3 0.048 13.1 0.3 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase UPF0176_N PF17773.1 ACT00684.1 - 1.1e-25 89.8 0.0 2.1e-25 88.9 0.0 1.5 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese_C PF12368.8 ACT00684.1 - 5.9e-18 65.0 16.3 1e-17 64.2 15.8 1.7 2 0 0 2 2 2 1 Rhodanase C-terminal Rhodanese PF00581.20 ACT00684.1 - 6.1e-11 42.8 0.0 1.4e-10 41.6 0.0 1.6 2 0 0 2 2 2 1 Rhodanese-like domain DUF1450 PF07293.11 ACT00685.1 - 3e-15 55.8 4.0 3.6e-15 55.5 4.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1450) DUF5332 PF17266.2 ACT00685.1 - 0.014 15.1 0.9 0.016 14.9 0.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5332) Nup54_C PF18437.1 ACT00685.1 - 0.097 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain UPF0176_N PF17773.1 ACT00686.1 - 5e-25 87.7 0.0 8.2e-25 87.0 0.0 1.3 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese_C PF12368.8 ACT00686.1 - 2.5e-18 66.2 11.8 5.2e-18 65.2 11.8 1.6 1 0 0 1 1 1 1 Rhodanase C-terminal Rhodanese PF00581.20 ACT00686.1 - 1e-09 38.8 0.0 1.9e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain LysR_substrate PF03466.20 ACT00687.1 - 1.6e-40 138.7 0.0 1.9e-40 138.5 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT00687.1 - 1.6e-20 72.8 0.0 4.2e-20 71.5 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 ACT00687.1 - 0.0012 18.0 0.0 0.033 13.3 0.0 2.3 1 1 0 1 1 1 1 PBP superfamily domain PBP_like_2 PF12849.7 ACT00687.1 - 0.01 15.5 0.0 0.065 12.9 0.0 2.0 2 0 0 2 2 2 0 PBP superfamily domain HTH_30 PF13556.6 ACT00687.1 - 0.019 14.8 0.0 0.045 13.6 0.0 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain MarR PF01047.22 ACT00687.1 - 0.052 13.5 0.0 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 MarR family Fe_dep_repress PF01325.19 ACT00687.1 - 0.15 12.3 0.0 4.3 7.6 0.0 2.5 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain Chorismate_synt PF01264.21 ACT00688.1 - 3.9e-138 459.6 2.1 4.6e-138 459.4 2.1 1.0 1 0 0 1 1 1 1 Chorismate synthase TerC PF03741.16 ACT00689.1 - 5e-48 163.2 13.8 5e-48 163.2 13.8 1.4 2 0 0 2 2 2 1 Integral membrane protein TerC family MarC PF01914.17 ACT00689.1 - 0.00039 19.9 0.9 0.00039 19.9 0.9 2.3 2 0 0 2 2 2 1 MarC family integral membrane protein Gemini_mov PF01708.16 ACT00689.1 - 0.41 10.4 3.1 0.27 11.0 0.7 1.9 2 0 0 2 2 2 0 Geminivirus putative movement protein OFeT_1 PF16955.5 ACT00689.1 - 0.55 9.9 10.4 0.98 9.1 10.4 1.6 1 1 0 1 1 1 0 Ferrous iron uptake permease, iron-lead transporter DUF2101 PF09874.9 ACT00689.1 - 1.6 8.4 5.9 0.53 9.9 2.9 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2101) RGI_lyase PF18370.1 ACT00690.1 - 8.5e-37 125.3 0.2 1.1e-35 121.8 0.0 2.7 2 0 0 2 2 2 1 Rhamnogalacturonan I lyases beta-sheet domain Cadherin-like PF12733.7 ACT00690.1 - 5.4e-13 49.3 2.4 5.4e-13 49.3 2.4 5.0 6 0 0 6 6 5 1 Cadherin-like beta sandwich domain VCBS PF13517.6 ACT00690.1 - 6.7e-08 33.0 12.6 0.013 16.0 0.1 5.9 5 1 0 5 5 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ACT00690.1 - 7.1e-08 32.4 23.1 0.0066 16.6 0.8 4.3 4 0 0 4 4 4 3 FG-GAP repeat fn3 PF00041.21 ACT00690.1 - 0.00034 20.9 1.4 0.014 15.7 0.0 4.2 4 0 0 4 4 4 1 Fibronectin type III domain DUF5011 PF16403.5 ACT00690.1 - 0.02 15.0 0.2 0.02 15.0 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5011) Big_3_2 PF12245.8 ACT00690.1 - 0.044 14.0 0.4 0.044 14.0 0.4 3.3 3 0 0 3 3 3 0 Bacterial Ig-like domain HYR PF02494.16 ACT00690.1 - 0.11 12.9 1.0 4.5 7.7 0.1 3.1 2 0 0 2 2 2 0 HYR domain Chitin_bind_4 PF00379.23 ACT00690.1 - 0.69 10.5 4.2 4.9 7.8 0.2 3.4 2 0 0 2 2 2 0 Insect cuticle protein Big_3_3 PF13750.6 ACT00690.1 - 0.82 9.3 7.9 0.34 10.5 1.6 3.5 3 1 0 3 3 3 0 Bacterial Ig-like domain (group 3) CHB_HEX_C_1 PF13290.6 ACT00690.1 - 2.7 8.1 8.8 1.2 9.1 0.1 4.1 4 0 0 4 4 4 0 Chitobiase/beta-hexosaminidase C-terminal domain Aconitase PF00330.20 ACT00691.1 - 1.4e-177 591.3 0.0 1.9e-177 590.9 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ACT00691.1 - 4.7e-46 156.4 0.0 9.1e-46 155.4 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Bac_luciferase PF00296.20 ACT00692.1 - 1.8e-34 119.6 0.3 4.9e-34 118.2 0.4 1.7 1 1 0 1 1 1 1 Luciferase-like monooxygenase DUF1685 PF07939.11 ACT00692.1 - 0.13 12.1 0.5 0.47 10.2 0.1 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1685) Enoyl_reductase PF12241.8 ACT00693.1 - 8e-114 378.9 0.5 1e-113 378.5 0.5 1.1 1 0 0 1 1 1 1 Trans-2-enoyl-CoA reductase catalytic region Eno-Rase_NADH_b PF12242.8 ACT00693.1 - 2.2e-35 120.3 0.6 5e-35 119.1 0.6 1.7 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Eno-Rase_FAD_bd PF07055.12 ACT00693.1 - 1.8e-30 105.1 2.9 3e-30 104.4 2.9 1.4 1 0 0 1 1 1 1 Enoyl reductase FAD binding domain adh_short_C2 PF13561.6 ACT00693.1 - 0.00094 18.8 0.6 1.2 8.6 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase SASP PF00269.20 ACT00694.1 - 1.1e-26 92.6 0.1 1.2e-26 92.4 0.1 1.0 1 0 0 1 1 1 1 Small, acid-soluble spore proteins, alpha/beta type DUF1843 PF08898.10 ACT00694.1 - 0.055 14.0 0.5 0.49 10.9 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) BMFP PF04380.13 ACT00695.1 - 0.00027 21.4 1.8 0.037 14.5 0.2 2.6 3 0 0 3 3 3 2 Membrane fusogenic activity Phasin PF05597.11 ACT00695.1 - 0.00028 20.9 1.2 0.00038 20.5 1.2 1.2 1 0 0 1 1 1 1 Poly(hydroxyalcanoate) granule associated protein (phasin) FeoC PF09012.10 ACT00695.1 - 0.004 17.2 0.2 0.0086 16.1 0.1 1.6 1 1 0 1 1 1 1 FeoC like transcriptional regulator Ppx-GppA PF02541.16 ACT00695.1 - 0.019 14.4 0.3 0.02 14.3 0.3 1.1 1 0 0 1 1 1 0 Ppx/GppA phosphatase family RBP_receptor PF14752.6 ACT00695.1 - 0.29 9.7 0.2 0.31 9.5 0.2 1.0 1 0 0 1 1 1 0 Retinol binding protein receptor ABC1 PF03109.16 ACT00696.1 - 4.5e-36 123.6 0.0 8e-36 122.8 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 ACT00696.1 - 6.4e-05 22.4 0.0 0.00066 19.1 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 ACT00696.1 - 7.2e-05 22.8 0.7 0.00024 21.1 0.7 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family WaaY PF06176.11 ACT00696.1 - 0.077 12.6 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) CotH PF08757.11 ACT00697.1 - 8.3e-64 216.1 4.4 1.2e-63 215.6 4.4 1.1 1 0 0 1 1 1 1 CotH kinase protein HipA_C PF07804.12 ACT00697.1 - 0.081 12.6 0.0 0.18 11.5 0.0 1.6 2 0 0 2 2 2 0 HipA-like C-terminal domain Erf4 PF10256.9 ACT00697.1 - 0.17 12.0 0.2 1 9.5 0.0 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family DUF4956 PF16316.5 ACT00698.1 - 1.4e-09 37.8 7.3 2.2e-09 37.2 7.3 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4956) MgtC PF02308.16 ACT00698.1 - 0.0003 21.1 11.3 0.0032 17.8 11.8 2.3 2 1 0 2 2 2 1 MgtC family Pox_L3_FP4 PF03339.14 ACT00698.1 - 0.057 12.4 1.1 0.092 11.7 1.1 1.3 1 0 0 1 1 1 0 Poxvirus L3/FP4 protein NapD PF03927.13 ACT00698.1 - 0.083 13.0 0.4 0.16 12.0 0.4 1.4 1 0 0 1 1 1 0 NapD protein Sec20 PF03908.13 ACT00698.1 - 0.096 12.6 0.1 0.096 12.6 0.1 2.1 3 0 0 3 3 3 0 Sec20 VTC PF09359.10 ACT00699.1 - 6.7e-25 88.0 1.1 2.8e-24 86.0 1.1 2.0 1 1 0 1 1 1 1 VTC domain HATPase_c PF02518.26 ACT00700.1 - 3.5e-25 88.7 0.0 6.4e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT00700.1 - 9.7e-18 64.0 1.3 2.3e-17 62.8 1.3 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT00700.1 - 1.1e-10 41.7 0.5 3.3e-10 40.2 0.5 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 ACT00700.1 - 0.00019 21.2 0.0 0.00034 20.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT00700.1 - 0.00041 20.3 0.0 0.00094 19.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain DUF2157 PF09925.9 ACT00700.1 - 0.14 11.9 2.8 2.5 7.9 0.2 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF4131 PF13567.6 ACT00700.1 - 0.68 9.6 3.2 0.56 9.8 0.4 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) Response_reg PF00072.24 ACT00701.1 - 1e-28 99.8 0.2 1.5e-28 99.2 0.2 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT00701.1 - 3.2e-25 88.0 0.2 6.7e-25 87.0 0.2 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Lactamase_B_3 PF13483.6 ACT00702.1 - 3.2e-23 82.4 0.1 4.1e-23 82.1 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 ACT00702.1 - 5.3e-19 68.5 0.2 7e-19 68.1 0.2 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACT00702.1 - 5.7e-14 52.6 1.2 7.8e-14 52.1 1.2 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Glyoxalase PF00903.25 ACT00703.1 - 4.3e-14 52.8 0.0 3.6e-06 27.2 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.6 ACT00703.1 - 0.044 13.8 0.0 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 CppA N-terminal Glyoxalase_2 PF12681.7 ACT00703.1 - 0.058 13.3 0.0 11 5.9 0.0 3.0 3 0 0 3 3 3 0 Glyoxalase-like domain Hydrolase_3 PF08282.12 ACT00704.1 - 2.1e-58 198.0 0.0 2.6e-58 197.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT00704.1 - 7.7e-14 52.5 0.2 7.2e-06 26.4 0.0 3.2 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ACT00704.1 - 1e-13 51.4 0.0 4.6e-10 39.5 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.7 ACT00704.1 - 1.6e-08 35.2 0.9 0.023 15.1 0.0 3.3 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ACT00704.1 - 0.00027 21.1 0.2 2.2 8.4 0.0 3.1 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ACT00704.1 - 0.00086 19.4 0.0 0.0019 18.3 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DHH PF01368.20 ACT00705.1 - 2.2e-31 108.1 0.0 3.7e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 DHH family DHHA2 PF02833.14 ACT00705.1 - 4.1e-20 72.4 0.6 6.8e-20 71.7 0.6 1.3 1 0 0 1 1 1 1 DHHA2 domain Acetyltransf_4 PF13420.7 ACT00706.1 - 6.9e-14 52.3 0.0 8.5e-14 52.0 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT00706.1 - 1e-13 51.5 0.0 1.3e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT00706.1 - 1.3e-13 51.0 0.0 1.7e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT00706.1 - 2.6e-10 40.6 0.0 3.6e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT00706.1 - 1.1e-07 31.7 0.0 1.8e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ACT00706.1 - 0.00022 21.9 0.0 0.00035 21.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT00706.1 - 0.014 15.4 0.1 0.04 14.0 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACT00706.1 - 0.032 14.4 0.0 0.06 13.5 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.6 ACT00706.1 - 0.04 13.6 0.0 0.089 12.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ACT00706.1 - 0.13 11.7 0.0 0.17 11.4 0.0 1.4 1 1 0 1 1 1 0 Putative acetyl-transferase NLPC_P60 PF00877.19 ACT00707.1 - 5.4e-28 97.1 0.0 7.6e-28 96.6 0.0 1.2 1 0 0 1 1 1 1 NlpC/P60 family CHAP PF05257.16 ACT00707.1 - 0.035 14.7 0.0 0.063 13.9 0.0 1.5 1 0 0 1 1 1 0 CHAP domain HTH_27 PF13463.6 ACT00708.1 - 2.8e-14 53.3 0.3 4.6e-14 52.7 0.3 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.22 ACT00708.1 - 4.6e-13 48.9 0.1 1.7e-12 47.1 0.1 2.0 1 1 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT00708.1 - 2.2e-12 46.7 0.1 3.8e-12 45.9 0.1 1.4 1 0 0 1 1 1 1 MarR family Fe_dep_repress PF01325.19 ACT00708.1 - 4e-09 36.5 0.1 7.3e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_24 PF13412.6 ACT00708.1 - 1.1e-05 24.9 0.0 2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 ACT00708.1 - 0.00011 22.0 0.0 0.00023 21.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family TrmB PF01978.19 ACT00708.1 - 0.00033 20.5 0.1 0.00058 19.7 0.1 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 ACT00708.1 - 0.00035 20.3 0.0 0.00078 19.2 0.0 1.7 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT00708.1 - 0.00051 20.0 0.1 0.00099 19.0 0.1 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HxlR PF01638.17 ACT00708.1 - 0.00076 19.3 0.1 0.0012 18.6 0.1 1.4 1 0 0 1 1 1 1 HxlR-like helix-turn-helix Penicillinase_R PF03965.16 ACT00708.1 - 0.002 18.5 0.1 0.0029 18.0 0.1 1.3 1 0 0 1 1 1 1 Penicillinase repressor DUF4423 PF14394.6 ACT00708.1 - 0.0034 17.1 0.0 0.005 16.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) B-block_TFIIIC PF04182.12 ACT00708.1 - 0.0037 17.4 0.0 0.0052 16.9 0.0 1.3 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC GntR PF00392.21 ACT00708.1 - 0.0039 16.8 0.1 0.0079 15.8 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_29 PF13551.6 ACT00708.1 - 0.0081 16.2 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_34 PF13601.6 ACT00708.1 - 0.012 15.7 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain SgrR_N PF12793.7 ACT00708.1 - 0.026 14.7 0.0 0.067 13.4 0.0 1.7 1 1 0 1 1 1 0 Sugar transport-related sRNA regulator N-term RPA_C PF08784.11 ACT00708.1 - 0.032 14.9 0.0 0.053 14.2 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal Rrf2 PF02082.20 ACT00708.1 - 0.033 14.5 0.1 0.055 13.8 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator RP-C PF03428.13 ACT00708.1 - 0.044 13.4 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 Replication protein C N-terminal domain HTH_23 PF13384.6 ACT00708.1 - 0.054 13.3 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_20 PF12840.7 ACT00708.1 - 0.055 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_11 PF08279.12 ACT00708.1 - 0.056 13.4 0.2 0.19 11.7 0.0 1.9 2 0 0 2 2 2 0 HTH domain FeoC PF09012.10 ACT00708.1 - 0.057 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 FeoC like transcriptional regulator DUF2089 PF09862.9 ACT00708.1 - 0.06 13.4 0.0 0.093 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) TFIIE_alpha PF02002.17 ACT00708.1 - 0.079 12.8 0.2 0.14 12.0 0.2 1.6 1 0 0 1 1 1 0 TFIIE alpha subunit EAP30 PF04157.16 ACT00708.1 - 0.088 12.1 0.1 0.27 10.5 0.0 1.7 2 0 0 2 2 2 0 EAP30/Vps36 family DUF2250 PF10007.9 ACT00708.1 - 0.092 12.9 0.2 0.25 11.5 0.1 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) SecD-TM1 PF13721.6 ACT00708.1 - 0.11 13.0 0.0 0.17 12.4 0.0 1.3 1 0 0 1 1 1 0 SecD export protein N-terminal TM region HTH_1 PF00126.27 ACT00708.1 - 0.13 12.2 0.7 0.76 9.8 0.4 2.4 2 1 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family ABC_membrane PF00664.23 ACT00709.1 - 3.9e-45 154.6 15.7 5.7e-45 154.1 15.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT00709.1 - 2.6e-31 109.0 0.0 3.4e-30 105.3 0.0 2.3 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ACT00709.1 - 6.5e-05 22.5 0.7 0.0015 18.0 0.7 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ACT00709.1 - 0.018 14.9 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 ACT00709.1 - 0.028 14.1 0.5 0.028 14.1 0.5 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_30 PF13604.6 ACT00709.1 - 0.093 12.4 0.3 0.67 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 ACT00709.1 - 0.12 12.5 0.8 0.21 11.6 0.2 1.7 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_23 PF13476.6 ACT00709.1 - 0.13 12.7 0.1 0.24 11.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 ACT00709.1 - 0.15 9.5 0.0 0.23 8.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) 7tm_7 PF08395.12 ACT00709.1 - 0.27 10.4 8.9 0.068 12.4 0.5 2.7 3 0 0 3 3 3 0 7tm Chemosensory receptor ABC_membrane PF00664.23 ACT00710.1 - 4.3e-63 213.5 14.7 5.6e-63 213.2 14.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT00710.1 - 3.3e-32 111.9 0.0 6.1e-32 111.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane_2 PF06472.15 ACT00710.1 - 5.2e-05 22.8 4.9 0.0001 21.8 4.9 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 AAA PF00004.29 ACT00710.1 - 9.5e-05 22.8 0.0 0.00065 20.1 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_membrane_3 PF13748.6 ACT00710.1 - 0.0002 20.7 0.2 0.0002 20.7 0.2 2.7 3 0 0 3 3 3 1 ABC transporter transmembrane region RsgA_GTPase PF03193.16 ACT00710.1 - 0.00022 21.1 0.0 0.00046 20.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ACT00710.1 - 0.0004 20.7 0.1 0.004 17.4 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ACT00710.1 - 0.00085 19.2 0.7 1.1 8.9 0.0 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ACT00710.1 - 0.00095 19.6 0.0 0.0032 17.9 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ACT00710.1 - 0.0032 18.0 0.3 0.013 16.0 0.1 2.0 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.19 ACT00710.1 - 0.0044 16.5 0.3 0.49 9.8 0.3 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ACT00710.1 - 0.011 15.9 0.1 0.037 14.1 0.1 2.0 2 0 0 2 2 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 ACT00710.1 - 0.011 15.4 0.2 0.043 13.5 0.2 1.9 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 ACT00710.1 - 0.013 14.6 0.1 0.027 13.5 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF87 PF01935.17 ACT00710.1 - 0.015 15.4 0.0 0.036 14.2 0.0 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain NTPase_1 PF03266.15 ACT00710.1 - 0.018 15.0 0.1 0.039 13.9 0.1 1.6 1 0 0 1 1 1 0 NTPase TsaE PF02367.17 ACT00710.1 - 0.028 14.4 0.0 0.078 13.0 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 ACT00710.1 - 0.032 14.0 0.0 0.094 12.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 ACT00710.1 - 0.044 14.3 0.0 0.086 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ACT00710.1 - 0.047 13.5 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 ACT00710.1 - 0.054 13.5 0.3 0.71 9.9 0.0 2.7 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 ACT00710.1 - 0.057 13.0 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 ACT00710.1 - 0.063 13.2 0.2 0.44 10.4 0.0 2.3 2 0 0 2 2 2 0 NACHT domain Rad17 PF03215.15 ACT00710.1 - 0.063 13.2 0.2 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain DEAD PF00270.29 ACT00710.1 - 0.065 13.0 0.4 0.74 9.6 0.4 2.3 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_24 PF13479.6 ACT00710.1 - 0.077 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ACT00710.1 - 0.089 13.0 0.1 0.45 10.7 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ACT00710.1 - 0.12 12.8 0.1 0.4 11.0 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ACT00710.1 - 0.15 11.7 0.1 0.72 9.4 0.0 2.1 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 ACT00710.1 - 0.16 12.1 0.3 0.46 10.7 0.3 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ACT00710.1 - 0.17 11.9 0.4 1.6 8.7 0.0 2.5 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) DUF3671 PF12420.8 ACT00710.1 - 0.48 10.5 13.1 1.3 9.1 2.2 3.0 2 1 1 3 3 3 0 Protein of unknown function PrgI PF12666.7 ACT00710.1 - 1 10.1 5.4 0.2 12.4 0.6 2.4 3 0 0 3 3 1 0 PrgI family protein TraS PF10624.9 ACT00711.1 - 1.6 8.6 9.8 3.5 7.5 2.3 2.2 1 1 1 2 2 2 0 Plasmid conjugative transfer entry exclusion protein TraS EMP70 PF02990.16 ACT00711.1 - 3.7 6.1 15.8 0.77 8.4 12.6 1.4 1 1 0 1 1 1 0 Endomembrane protein 70 DUF438 PF04282.13 ACT00713.1 - 0.011 15.7 0.3 0.029 14.3 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF438) DUF4362 PF14275.6 ACT00715.1 - 7.7e-07 29.3 0.1 9.4e-07 29.0 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4362) Inhibitor_I67 PF11405.8 ACT00715.1 - 0.16 12.3 0.5 1.3 9.3 0.0 2.1 2 0 0 2 2 2 0 Bromelain inhibitor VI Acetyltransf_1 PF00583.25 ACT00716.1 - 3.1e-10 40.3 0.0 3.6e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT00716.1 - 9.9e-09 35.5 0.0 1.3e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT00716.1 - 3.9e-07 30.0 0.0 5.4e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT00716.1 - 2.9e-05 24.1 0.0 9.1e-05 22.5 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT00716.1 - 0.0095 15.9 0.0 0.02 14.8 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ACT00716.1 - 0.011 15.8 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 ACT00716.1 - 0.022 14.7 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase HAD_2 PF13419.6 ACT00717.1 - 4.1e-33 114.9 0.0 5.6e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT00717.1 - 4.1e-15 56.6 0.0 3e-14 53.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT00717.1 - 1.3e-09 37.9 0.0 2.4e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ACT00717.1 - 3.7e-08 34.0 0.1 4.8e-08 33.6 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase 5_nucleotid PF05761.14 ACT00717.1 - 0.021 13.7 0.0 0.75 8.6 0.0 2.2 2 0 0 2 2 2 0 5' nucleotidase family Hydrolase_6 PF13344.6 ACT00717.1 - 0.031 14.4 0.0 4.9 7.3 0.0 2.7 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase SBP_bac_8 PF13416.6 ACT00718.1 - 4.2e-30 105.5 7.6 6e-30 105.0 7.6 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT00718.1 - 4.4e-17 63.0 10.1 7.8e-17 62.2 10.1 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT00719.1 - 3.6e-18 65.9 11.0 3.6e-18 65.9 11.0 1.9 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT00720.1 - 1.2e-17 64.3 12.2 1.2e-17 64.3 12.2 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component dCache_1 PF02743.18 ACT00721.1 - 4.8e-28 98.6 7.8 4.8e-28 98.6 7.8 1.8 2 0 0 2 2 2 1 Cache domain His_kinase PF06580.13 ACT00721.1 - 1.1e-27 96.2 1.2 5e-27 94.1 0.5 2.3 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACT00721.1 - 3.3e-11 43.7 0.1 1.2e-10 41.9 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT00721.1 - 2.8e-10 40.4 0.0 5.9e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c_2 PF13581.6 ACT00721.1 - 4.5e-05 23.4 0.0 9.4e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACT00721.1 - 0.045 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FtsX PF02687.21 ACT00721.1 - 0.071 13.6 1.9 1 9.9 0.0 2.4 2 0 0 2 2 2 0 FtsX-like permease family Sigma_reg_N PF13800.6 ACT00721.1 - 0.61 10.4 8.5 8.8 6.7 0.3 3.3 3 0 0 3 3 3 0 Sigma factor regulator N-terminal DUF3139 PF11337.8 ACT00721.1 - 3.1 8.5 8.7 2.9 8.6 0.7 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) Response_reg PF00072.24 ACT00722.1 - 2e-23 82.7 0.2 4.2e-23 81.6 0.2 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT00722.1 - 2.4e-20 72.1 0.5 8e-09 35.4 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT00722.1 - 5.3e-18 65.1 0.0 1e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain GGDEF_2 PF17853.1 ACT00722.1 - 9.9e-09 35.5 0.0 2.3e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 GGDEF-like domain MOR2-PAG1_C PF14225.6 ACT00722.1 - 0.06 13.2 0.2 0.099 12.5 0.2 1.2 1 0 0 1 1 1 0 Cell morphogenesis C-terminal SBP_bac_8 PF13416.6 ACT00723.1 - 5.9e-27 95.2 0.0 7.3e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT00723.1 - 5.3e-18 66.0 0.0 7.7e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Acetyltransf_1 PF00583.25 ACT00724.1 - 2.5e-13 50.3 0.1 2.8e-13 50.1 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT00724.1 - 7.3e-11 42.3 0.1 9.7e-11 42.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT00724.1 - 2.5e-10 40.4 0.0 3.1e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT00724.1 - 0.0001 22.4 0.0 0.00014 22.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT00724.1 - 0.00013 21.9 0.0 0.00021 21.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ACT00724.1 - 0.00028 20.9 0.0 0.00039 20.5 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase HicA_toxin PF07927.12 ACT00724.1 - 0.056 13.5 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, Acetyltransf_3 PF13302.7 ACT00724.1 - 0.088 13.5 0.0 0.096 13.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_16 PF05301.11 ACT00724.1 - 0.09 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 SBP_bac_8 PF13416.6 ACT00725.1 - 2e-17 63.9 8.2 2e-17 63.9 8.2 1.9 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT00725.1 - 3.5e-17 63.3 14.2 3.5e-17 63.3 14.2 1.5 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein Secretin_N_2 PF07655.13 ACT00725.1 - 0.017 15.7 1.0 0.017 15.7 1.0 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain BPD_transp_1 PF00528.22 ACT00726.1 - 1.6e-15 57.3 8.9 1.6e-15 57.3 8.9 1.9 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2768 PF10966.8 ACT00726.1 - 0.035 14.6 0.8 0.035 14.6 0.8 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2768) BPD_transp_1 PF00528.22 ACT00727.1 - 2.6e-14 53.4 15.2 2.6e-14 53.4 15.2 2.8 1 1 1 3 3 3 1 Binding-protein-dependent transport system inner membrane component Glyco_hydro_88 PF07470.13 ACT00728.1 - 4.9e-26 91.6 1.2 6.3e-26 91.3 1.2 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_47 PF01532.20 ACT00728.1 - 0.13 11.1 0.4 7.4 5.3 0.1 2.4 3 0 0 3 3 3 0 Glycosyl hydrolase family 47 HTH_18 PF12833.7 ACT00729.1 - 1.4e-16 60.5 0.0 3.4e-16 59.3 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain dCache_1 PF02743.18 ACT00729.1 - 2.8e-12 47.0 1.6 6.3e-12 45.8 1.6 1.6 1 0 0 1 1 1 1 Cache domain HTH_AraC PF00165.23 ACT00729.1 - 8e-11 41.8 0.1 9.1e-06 25.6 0.0 3.2 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT00729.1 - 8.3e-09 35.7 0.0 2.6e-08 34.1 0.0 1.9 1 0 0 1 1 1 1 GGDEF-like domain GlutR_dimer PF00745.20 ACT00729.1 - 0.019 15.4 0.7 0.81 10.2 0.0 3.5 3 0 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain Rrf2 PF02082.20 ACT00729.1 - 0.05 14.0 0.0 11 6.4 0.0 2.8 2 0 0 2 2 2 0 Transcriptional regulator APG6_N PF17675.1 ACT00729.1 - 0.058 13.9 2.4 0.17 12.4 1.2 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region SBP_bac_1 PF01547.25 ACT00730.1 - 7.2e-17 62.3 0.8 1.4e-16 61.4 0.8 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT00730.1 - 4e-16 59.6 0.0 1.2e-15 58.1 0.0 1.7 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein Phage_holin_4_1 PF05105.12 ACT00731.1 - 2.6e-36 124.2 1.7 3.1e-36 124.0 1.7 1.1 1 0 0 1 1 1 1 Bacteriophage holin family Tachystatin_A PF11406.8 ACT00732.1 - 0.02 14.9 0.1 0.036 14.1 0.1 1.3 1 0 0 1 1 1 0 Antimicrobial peptide tachystatin A Cupredoxin_1 PF13473.6 ACT00733.1 - 0.00013 22.1 0.0 0.00015 21.8 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 ACT00733.1 - 0.0032 17.9 0.4 0.17 12.3 0.4 2.1 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family COX2 PF00116.20 ACT00733.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, periplasmic domain Internalin_N PF12354.8 ACT00734.1 - 0.5 10.5 3.0 0.62 10.2 0.1 2.1 1 1 1 2 2 2 0 Bacterial adhesion/invasion protein N terminal Dabb PF07876.12 ACT00735.1 - 2.1e-25 89.2 1.0 2.3e-25 89.1 1.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain ABM PF03992.16 ACT00735.1 - 0.00055 20.0 0.1 0.0019 18.3 0.1 1.8 1 1 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF4188 PF13826.6 ACT00735.1 - 0.0072 16.7 0.0 0.0087 16.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) POTRA_3 PF17287.2 ACT00735.1 - 0.011 15.2 0.0 0.088 12.3 0.0 2.0 2 0 0 2 2 2 0 POTRA domain PgaD PF13994.6 ACT00736.1 - 0.039 14.0 0.1 0.039 14.0 0.1 1.0 1 0 0 1 1 1 0 PgaD-like protein Glucos_trans_II PF14264.6 ACT00736.1 - 0.072 12.4 0.5 0.077 12.3 0.5 1.0 1 0 0 1 1 1 0 Glucosyl transferase GtrII DUF86 PF01934.17 ACT00737.1 - 5.1e-08 32.8 0.0 6.2e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF86 MRP-S33 PF08293.11 ACT00737.1 - 0.019 15.2 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit S27 HTH_24 PF13412.6 ACT00738.1 - 3.6e-09 36.0 0.3 2.3e-07 30.2 0.1 3.0 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 ACT00738.1 - 6.8e-08 32.3 0.2 9.2e-07 28.7 0.0 2.4 2 0 0 2 2 2 1 HTH domain HTH_5 PF01022.20 ACT00738.1 - 2.7e-05 24.0 0.6 0.00049 19.9 0.0 2.8 3 0 0 3 3 3 1 Bacterial regulatory protein, arsR family HTH_AsnC-type PF13404.6 ACT00738.1 - 9.9e-05 22.1 0.2 0.00096 18.9 0.0 2.5 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain HTH_20 PF12840.7 ACT00738.1 - 0.00043 20.3 0.3 0.0068 16.5 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_DeoR PF08220.12 ACT00738.1 - 0.0015 18.2 0.0 0.0052 16.5 0.0 1.9 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain MarR PF01047.22 ACT00738.1 - 0.0025 17.7 0.0 0.0087 16.0 0.0 1.9 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.7 ACT00738.1 - 0.012 15.4 0.4 0.18 11.7 0.1 2.2 2 0 0 2 2 2 0 MarR family ATC_hydrolase PF14196.6 ACT00738.1 - 0.02 15.7 0.9 0.052 14.3 0.9 1.7 1 1 0 1 1 1 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase TFIIE_alpha PF02002.17 ACT00738.1 - 0.021 14.7 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 TFIIE alpha subunit HTH_34 PF13601.6 ACT00738.1 - 0.046 13.9 0.0 0.092 12.9 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain Cofac_haem_bdg PF04187.13 ACT00738.1 - 0.049 13.6 0.0 0.068 13.1 0.0 1.2 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN GntR PF00392.21 ACT00738.1 - 0.12 12.0 0.1 0.24 11.1 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_23 PF13384.6 ACT00738.1 - 0.15 11.9 0.0 0.43 10.4 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain V4R PF02830.18 ACT00738.1 - 0.22 11.6 2.1 0.8 9.8 2.1 2.0 1 1 0 1 1 1 0 V4R domain DUF948 PF06103.11 ACT00739.1 - 3.4e-10 40.0 3.7 4.4e-10 39.7 3.2 1.4 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF948) HisKA_3 PF07730.13 ACT00739.1 - 0.11 13.0 5.8 4.4 7.9 2.4 2.3 2 0 0 2 2 2 0 Histidine kinase Arch_flagellin PF01917.16 ACT00739.1 - 3.6 7.8 8.2 2 8.5 1.1 2.1 2 0 0 2 2 2 0 Archaebacterial flagellin Corona_S2 PF01601.16 ACT00739.1 - 4 5.8 5.9 14 4.0 5.9 1.8 1 1 0 1 1 1 0 Coronavirus S2 glycoprotein YtxH PF12732.7 ACT00740.1 - 1.6e-18 67.0 10.3 2.6e-17 63.1 1.2 2.4 1 1 1 2 2 2 2 YtxH-like protein ApoLp-III PF07464.11 ACT00740.1 - 0.00087 19.4 2.8 0.0027 17.8 2.0 1.8 1 1 1 2 2 2 1 Apolipophorin-III precursor (apoLp-III) Apolipoprotein PF01442.18 ACT00740.1 - 0.001 19.0 6.9 0.0014 18.6 6.9 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Synuclein PF01387.17 ACT00740.1 - 0.0025 18.0 4.7 0.0035 17.6 4.7 1.1 1 0 0 1 1 1 1 Synuclein EspB PF05802.11 ACT00740.1 - 0.003 17.6 9.7 0.0038 17.2 9.7 1.2 1 0 0 1 1 1 1 Enterobacterial EspB protein Tim17 PF02466.19 ACT00740.1 - 0.047 14.1 0.2 0.076 13.4 0.2 1.6 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family DUF883 PF05957.13 ACT00740.1 - 0.076 13.6 12.8 0.077 13.6 5.2 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Phasin PF05597.11 ACT00740.1 - 0.099 12.6 3.9 0.14 12.2 3.9 1.2 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) PhoU PF01895.19 ACT00740.1 - 0.1 13.1 1.9 0.28 11.7 0.8 2.0 1 1 1 2 2 2 0 PhoU domain Phasin_2 PF09361.10 ACT00740.1 - 0.12 12.7 6.8 1.4 9.2 3.2 2.2 1 1 1 2 2 2 0 Phasin protein DUF3169 PF11368.8 ACT00740.1 - 0.16 11.4 0.1 0.16 11.5 0.1 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3169) GCN5L1 PF06320.13 ACT00740.1 - 0.19 11.9 2.9 0.41 10.8 0.4 2.0 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) REF PF05755.12 ACT00740.1 - 0.26 11.1 1.7 0.32 10.8 1.7 1.2 1 0 0 1 1 1 0 Rubber elongation factor protein (REF) Tape_meas_lam_C PF09718.10 ACT00740.1 - 0.29 11.3 2.9 2.1 8.5 0.5 2.4 1 1 1 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Pup PF05639.11 ACT00740.1 - 0.57 11.1 4.9 0.65 10.9 4.0 1.6 1 1 1 2 2 2 0 Pup-like protein SseC PF04888.12 ACT00740.1 - 1.1 8.8 10.8 2.3 7.7 10.8 1.5 1 1 0 1 1 1 0 Secretion system effector C (SseC) like family Asp_Glu_race PF01177.22 ACT00741.1 - 1.5e-35 123.1 0.0 1.7e-35 122.9 0.0 1.0 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase MarR PF01047.22 ACT00742.1 - 1.4e-12 47.3 0.0 2.2e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT00742.1 - 6.3e-08 33.0 0.0 1.1e-07 32.3 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_34 PF13601.6 ACT00742.1 - 9.7e-05 22.5 0.6 0.00057 20.0 0.2 2.0 1 1 1 2 2 2 1 Winged helix DNA-binding domain MarR_2 PF12802.7 ACT00742.1 - 0.0005 19.9 0.0 0.0007 19.4 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT00742.1 - 0.00082 18.9 0.0 0.0019 17.7 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding PadR PF03551.14 ACT00742.1 - 0.0016 18.4 0.0 0.004 17.1 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family PBECR5 PF18814.1 ACT00742.1 - 0.0026 17.7 3.1 0.0029 17.6 3.1 1.1 1 0 0 1 1 1 1 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 HTH_45 PF14947.6 ACT00742.1 - 0.0028 17.6 0.3 0.0051 16.8 0.3 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DUF1495 PF07381.11 ACT00742.1 - 0.0066 16.2 0.1 0.012 15.5 0.1 1.5 1 1 0 1 1 1 1 Winged helix DNA-binding domain (DUF1495) FeoC PF09012.10 ACT00742.1 - 0.0086 16.1 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 FeoC like transcriptional regulator HxlR PF01638.17 ACT00742.1 - 0.04 13.8 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Rrf2 PF02082.20 ACT00742.1 - 0.11 12.8 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator MFS_1 PF07690.16 ACT00743.1 - 4.8e-48 163.9 46.2 1.6e-33 116.1 23.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT00743.1 - 4.3e-12 45.6 10.4 4.3e-12 45.6 10.4 2.9 2 1 0 2 2 2 1 Sugar (and other) transporter PUCC PF03209.15 ACT00743.1 - 0.00022 20.4 3.1 0.00022 20.4 3.1 3.1 2 2 1 3 3 3 2 PUCC protein TRI12 PF06609.13 ACT00743.1 - 0.00059 18.4 2.4 0.00059 18.4 2.4 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 ACT00743.1 - 0.00066 18.2 14.1 0.0061 15.0 9.2 2.2 1 1 1 2 2 2 2 Transmembrane secretion effector IER PF05760.12 ACT00743.1 - 0.11 12.8 0.2 0.16 12.2 0.2 1.2 1 0 0 1 1 1 0 Immediate early response protein (IER) Peptidase_M14 PF00246.24 ACT00744.1 - 6.4e-33 114.8 0.0 1.9e-32 113.2 0.0 1.7 1 1 0 1 1 1 1 Zinc carboxypeptidase Fe-S_biosyn PF01521.20 ACT00746.1 - 0.0019 18.4 0.0 0.0024 18.1 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis PDZ_2 PF13180.6 ACT00747.1 - 2e-11 44.0 0.2 3.5e-11 43.2 0.2 1.4 1 0 0 1 1 1 1 PDZ domain Lon_C PF05362.13 ACT00747.1 - 5.1e-07 29.4 0.0 1.1e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain PDZ_6 PF17820.1 ACT00747.1 - 1.2e-06 28.2 0.1 4.8e-05 23.1 0.0 2.6 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 ACT00747.1 - 1.1e-05 25.7 0.3 2.2e-05 24.7 0.3 1.5 1 0 0 1 1 1 1 PDZ domain Peptidase_M17 PF00883.21 ACT00747.1 - 0.0014 18.0 0.6 0.0022 17.3 0.6 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Tricorn_PDZ PF14685.6 ACT00747.1 - 0.039 13.9 0.1 0.089 12.8 0.1 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain DUF1772 PF08592.11 ACT00747.1 - 1.1 9.5 5.5 2.7 8.3 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) FA_desaturase PF00487.24 ACT00747.1 - 6.1 6.6 7.5 12 5.6 7.5 1.5 1 1 0 1 1 1 0 Fatty acid desaturase Sulfatase PF00884.23 ACT00748.1 - 2.5e-42 145.4 1.7 3.4e-42 144.9 1.7 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACT00748.1 - 0.019 14.6 0.0 0.049 13.2 0.0 1.7 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase UPF0020 PF01170.18 ACT00749.1 - 1.5e-47 161.9 0.0 2e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 THUMP PF02926.17 ACT00749.1 - 1.1e-08 35.3 0.0 1.7e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 THUMP domain MTS PF05175.14 ACT00749.1 - 0.0003 20.4 0.0 0.00058 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ACT00749.1 - 0.021 14.6 0.0 1.8 8.4 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain N6_Mtase PF02384.16 ACT00749.1 - 0.072 12.4 0.0 1.3 8.2 0.0 2.2 2 0 0 2 2 2 0 N-6 DNA Methylase N6_N4_Mtase PF01555.18 ACT00749.1 - 0.093 12.4 0.0 0.23 11.1 0.0 1.7 2 0 0 2 2 2 0 DNA methylase AviRa PF11599.8 ACT00749.1 - 0.11 12.0 0.1 6.7 6.1 0.0 2.8 2 1 1 3 3 3 0 RRNA methyltransferase AviRa Methyltransf_3 PF01596.17 ACT00750.1 - 1.6e-35 122.3 0.0 1.8e-35 122.1 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ACT00750.1 - 1e-11 45.8 0.0 1.5e-11 45.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ACT00750.1 - 0.00085 19.1 0.0 0.0011 18.8 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF1442 PF07279.11 ACT00750.1 - 0.025 13.9 0.0 0.038 13.3 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1442) N_methyl PF07963.12 ACT00751.1 - 5.4e-07 28.9 2.1 8.3e-07 28.3 2.1 1.3 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif N_methyl PF07963.12 ACT00752.1 - 3.1e-06 26.5 1.7 8.1e-06 25.2 1.7 1.7 2 0 0 2 2 2 1 Prokaryotic N-terminal methylation motif Phage_holin_2_3 PF16080.5 ACT00752.1 - 0.012 15.3 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage holin family HP1 Phage_holin_2_1 PF04971.12 ACT00752.1 - 0.037 14.0 0.0 0.063 13.3 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage P21 holin S YjcZ_2 PF09680.10 ACT00753.1 - 0.049 13.3 0.5 0.14 11.8 0.5 1.7 1 0 0 1 1 1 0 Family of unknown function Tad PF13400.6 ACT00753.1 - 1.1 9.6 3.4 2.3 8.6 3.4 1.5 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like Big_2 PF02368.18 ACT00754.1 - 1.4e-30 105.0 58.5 3.9e-12 45.9 8.6 8.2 8 0 0 8 8 8 6 Bacterial Ig-like domain (group 2) DUF5057 PF16480.5 ACT00754.1 - 1.9e-24 86.7 17.8 1.9e-24 86.7 17.8 4.2 3 1 0 3 3 3 1 Domain of unknown function (DUF5057) RicinB_lectin_2 PF14200.6 ACT00754.1 - 1.6e-07 31.9 10.2 6.7e-07 29.9 5.0 6.2 5 2 1 6 6 6 2 Ricin-type beta-trefoil lectin domain-like CARDB PF07705.11 ACT00754.1 - 0.0049 17.1 1.2 0.0049 17.1 1.2 6.6 5 3 3 8 8 8 1 CARDB T2SSE PF00437.20 ACT00755.1 - 5.5e-81 271.6 3.2 8.1e-81 271.1 3.2 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein T2SSE_N PF05157.15 ACT00755.1 - 2.6e-29 101.6 2.4 1.1e-28 99.6 0.1 2.6 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein E, N-terminal domain AAA_16 PF13191.6 ACT00755.1 - 0.00035 21.0 0.0 0.001 19.5 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT00755.1 - 0.00038 20.7 0.0 0.0012 19.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ACT00755.1 - 0.0015 18.6 0.0 0.0035 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ACT00755.1 - 0.003 17.9 0.0 0.01 16.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ACT00755.1 - 0.0037 17.2 0.0 0.0089 16.0 0.0 1.6 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 ACT00755.1 - 0.0041 16.7 0.0 0.0099 15.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_11 PF13086.6 ACT00755.1 - 0.0058 16.5 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ACT00755.1 - 0.0059 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT00755.1 - 0.007 16.1 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACT00755.1 - 0.0071 16.9 0.1 0.0071 16.9 0.1 2.2 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 ACT00755.1 - 0.0078 15.8 0.1 0.02 14.5 0.1 1.7 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 ACT00755.1 - 0.0081 16.7 0.2 0.027 15.0 0.0 2.1 2 1 0 2 2 2 1 ABC transporter Rad17 PF03215.15 ACT00755.1 - 0.011 15.6 0.0 0.033 14.1 0.0 1.7 2 0 0 2 2 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 ACT00755.1 - 0.026 14.4 1.0 0.082 12.8 0.1 2.3 3 0 0 3 3 3 0 NTPase ATP_bind_1 PF03029.17 ACT00755.1 - 0.05 13.4 0.1 0.23 11.2 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ResIII PF04851.15 ACT00755.1 - 0.063 13.3 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit MobB PF03205.14 ACT00755.1 - 0.096 12.6 0.1 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DAP3 PF10236.9 ACT00755.1 - 0.096 11.8 0.1 0.49 9.5 0.0 2.1 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 Herpes_Helicase PF02689.14 ACT00755.1 - 0.13 10.2 0.0 0.19 9.6 0.0 1.1 1 0 0 1 1 1 0 Helicase T2SSE PF00437.20 ACT00756.1 - 2.4e-39 135.0 3.0 2.4e-39 135.0 3.0 1.7 2 1 0 2 2 2 1 Type II/IV secretion system protein AAA_16 PF13191.6 ACT00756.1 - 3.5e-05 24.3 0.2 7.6e-05 23.2 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT00756.1 - 0.00011 22.4 0.0 0.00029 21.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain TrwB_AAD_bind PF10412.9 ACT00756.1 - 0.00019 20.5 0.0 0.00042 19.3 0.0 1.5 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA PF00004.29 ACT00756.1 - 0.00033 21.1 0.1 0.00084 19.8 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ACT00756.1 - 0.00083 18.7 0.0 0.0016 17.8 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_23 PF13476.6 ACT00756.1 - 0.0014 19.2 0.0 0.0026 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT00756.1 - 0.0031 17.2 0.2 0.0071 16.1 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ACT00756.1 - 0.0034 17.1 1.3 0.032 13.9 0.1 2.5 1 1 1 2 2 2 1 AAA domain ABC_tran PF00005.27 ACT00756.1 - 0.0038 17.8 0.0 0.0085 16.6 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_7 PF12775.7 ACT00756.1 - 0.0077 15.8 0.0 0.017 14.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_19 PF13245.6 ACT00756.1 - 0.0083 16.5 2.5 0.03 14.6 0.1 2.6 2 1 1 3 3 3 1 AAA domain DUF87 PF01935.17 ACT00756.1 - 0.0087 16.2 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 1 Helicase HerA, central domain ResIII PF04851.15 ACT00756.1 - 0.0091 16.0 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.18 ACT00756.1 - 0.011 15.1 0.3 0.032 13.6 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family TK PF00265.18 ACT00756.1 - 0.019 14.9 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 Thymidine kinase AAA_27 PF13514.6 ACT00756.1 - 0.034 13.7 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ACT00756.1 - 0.037 13.8 0.3 0.11 12.3 0.1 1.8 1 1 0 2 2 2 0 AAA domain Rad17 PF03215.15 ACT00756.1 - 0.039 13.9 0.0 0.076 12.9 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain NTPase_1 PF03266.15 ACT00756.1 - 0.044 13.7 0.2 3.2 7.6 0.1 2.5 1 1 1 2 2 2 0 NTPase ATP_bind_1 PF03029.17 ACT00756.1 - 0.051 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 ACT00756.1 - 0.051 13.6 0.0 0.089 12.9 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase Adeno_IVa2 PF02456.15 ACT00756.1 - 0.064 12.0 0.0 0.13 11.0 0.0 1.4 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_18 PF13238.6 ACT00756.1 - 0.082 13.5 0.0 0.13 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA12 PF10443.9 ACT00756.1 - 0.11 11.2 0.0 0.24 10.1 0.0 1.5 2 0 0 2 2 2 0 RNA12 protein DUF815 PF05673.13 ACT00756.1 - 0.12 11.5 0.0 0.23 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 ACT00756.1 - 0.13 12.3 0.0 0.27 11.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SMC_N PF02463.19 ACT00756.1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT00756.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system RNA_helicase PF00910.22 ACT00756.1 - 0.15 12.4 0.0 0.42 11.0 0.0 1.8 2 0 0 2 2 1 0 RNA helicase T2SSF PF00482.23 ACT00757.1 - 5.3e-56 187.9 1.1 1.4e-27 96.1 0.1 2.2 2 0 0 2 2 2 2 Type II secretion system (T2SS), protein F N_methyl PF07963.12 ACT00758.1 - 2.3e-08 33.2 2.4 3.4e-08 32.7 2.4 1.3 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif DiS_P_DiS PF06750.13 ACT00759.1 - 6.7e-31 106.3 0.3 1.3e-30 105.4 0.3 1.5 1 0 0 1 1 1 1 Bacterial Peptidase A24 N-terminal domain Peptidase_A24 PF01478.18 ACT00759.1 - 3e-16 59.7 13.8 3e-16 59.7 13.8 2.4 2 1 0 2 2 2 1 Type IV leader peptidase family DZR PF12773.7 ACT00759.1 - 0.017 15.1 0.3 0.028 14.4 0.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 ACT00759.1 - 0.069 12.9 1.8 5.3 6.9 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 ACT00759.1 - 0.09 12.9 0.4 10 6.3 0.2 2.2 2 0 0 2 2 2 0 Zinc ribbon domain DNA_RNApol_7kD PF03604.13 ACT00759.1 - 0.098 12.4 4.3 1.9 8.2 1.0 2.3 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Nudix_N_2 PF14803.6 ACT00759.1 - 0.23 11.4 1.3 13 5.8 0.1 2.2 2 0 0 2 2 2 0 Nudix N-terminal zf-ribbon_3 PF13248.6 ACT00759.1 - 0.26 10.7 1.6 2 8.0 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf_UBZ PF18439.1 ACT00759.1 - 0.37 10.4 1.9 20 4.9 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger PilM_2 PF11104.8 ACT00760.1 - 4.6e-17 62.1 0.0 8.9e-14 51.3 0.0 2.3 2 0 0 2 2 2 2 Type IV pilus assembly protein PilM; PilN PF05137.13 ACT00760.1 - 0.00034 20.7 0.0 0.00091 19.3 0.0 1.7 1 0 0 1 1 1 1 Fimbrial assembly protein (PilN) DUF1073 PF06381.11 ACT00760.1 - 0.085 11.6 0.9 0.23 10.2 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1073) T2SSM_b PF10741.9 ACT00761.1 - 1.1e-05 25.2 0.1 2e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein M subtype b PilO PF04350.13 ACT00761.1 - 4.2e-05 23.7 0.6 0.00057 20.1 0.1 2.4 1 1 1 2 2 2 1 Pilus assembly protein, PilO T2SSM PF04612.12 ACT00761.1 - 4.6e-05 23.5 3.1 0.0081 16.2 0.7 2.3 2 1 0 2 2 2 2 Type II secretion system (T2SS), protein M TssO PF17561.2 ACT00761.1 - 0.02 15.0 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 Type VI secretion system, TssO URO-D PF01208.17 ACT00762.1 - 2.2e-116 388.8 0.0 2.5e-116 388.6 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Ferrochelatase PF00762.19 ACT00763.1 - 1.6e-78 264.0 0.0 2e-78 263.7 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase HNH_repeat PF18780.1 ACT00763.1 - 7.7 6.4 6.9 16 5.4 1.5 2.5 2 0 0 2 2 2 0 Homing endonuclease repeat Amino_oxidase PF01593.24 ACT00764.1 - 1e-60 206.3 0.0 1.2e-60 206.2 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ACT00764.1 - 1.7e-09 37.8 0.0 2.9e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain MCRA PF06100.11 ACT00764.1 - 1.5e-05 24.0 0.0 2.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 MCRA family DAO PF01266.24 ACT00764.1 - 2.4e-05 24.1 0.8 5.4e-05 22.9 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ACT00764.1 - 2.9e-05 23.4 0.1 0.0088 15.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ACT00764.1 - 3.3e-05 23.9 0.8 0.005 16.9 0.1 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding ApbA PF02558.16 ACT00764.1 - 0.041 13.5 0.1 0.6 9.7 0.0 2.5 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 ACT00764.1 - 0.075 13.6 0.4 0.23 12.0 0.1 2.0 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ACT00764.1 - 0.1 11.6 0.3 0.35 9.9 0.2 1.9 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 ACT00764.1 - 0.16 11.2 0.8 0.22 10.8 0.1 1.6 2 0 0 2 2 2 0 Thi4 family Trp_halogenase PF04820.14 ACT00764.1 - 0.17 10.7 0.2 0.26 10.1 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 ACT00764.1 - 0.24 10.7 0.1 0.37 10.1 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase PGA_cap PF09587.10 ACT00765.1 - 1.2e-77 260.8 0.3 1.9e-77 260.2 0.3 1.3 1 0 0 1 1 1 1 Bacterial capsule synthesis protein PGA_cap GDPD PF03009.17 ACT00766.1 - 3.1e-31 109.0 0.0 5.9e-31 108.1 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ACT00766.1 - 0.00042 20.7 0.3 0.008 16.6 0.0 2.6 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family DUF92 PF01940.16 ACT00767.1 - 2e-64 217.2 12.9 2.4e-64 217.0 12.9 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 TRI9 PF08195.11 ACT00767.1 - 0.22 11.4 7.9 0.53 10.2 3.3 3.3 2 1 1 3 3 3 0 TRI9 protein LapA_dom PF06305.11 ACT00767.1 - 1 9.2 0.1 1 9.2 0.1 3.6 5 0 0 5 5 5 0 Lipopolysaccharide assembly protein A domain Glyoxalase PF00903.25 ACT00768.1 - 1.9e-07 31.4 0.0 3.8e-07 30.4 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ACT00768.1 - 8.7e-06 26.5 0.1 1e-05 26.3 0.1 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Methyltransf_11 PF08241.12 ACT00769.1 - 6.9e-20 71.5 0.0 2.1e-19 69.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT00769.1 - 6.4e-16 58.8 0.0 1.1e-15 58.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT00769.1 - 1.6e-10 41.6 0.0 2.6e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT00769.1 - 5.3e-10 39.4 0.0 7.4e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT00769.1 - 1.6e-05 24.8 0.0 2.5e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ACT00769.1 - 5.8e-05 22.5 0.0 8.3e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family RrnaAD PF00398.20 ACT00769.1 - 0.00016 20.8 0.0 0.00024 20.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.14 ACT00769.1 - 0.0036 16.9 0.0 0.0063 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 ACT00769.1 - 0.0059 16.5 0.0 0.011 15.5 0.0 1.4 2 0 0 2 2 2 1 Hypothetical methyltransferase FtsJ PF01728.19 ACT00769.1 - 0.07 13.2 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Cyclase PF04199.13 ACT00770.1 - 2e-38 131.7 0.1 2.6e-38 131.3 0.1 1.2 1 0 0 1 1 1 1 Putative cyclase DUF4362 PF14275.6 ACT00771.1 - 6e-35 119.4 1.4 1.2e-34 118.5 1.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4362) Peptidase_M3 PF01432.20 ACT00772.1 - 1e-71 242.6 5.0 1.8e-71 241.8 5.0 1.4 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M3_N PF08439.10 ACT00772.1 - 5.2e-23 81.1 0.4 2.7e-22 78.8 0.1 2.5 2 0 0 2 2 2 1 Oligopeptidase F Peptidase_M78 PF06114.13 ACT00772.1 - 0.015 15.2 0.0 0.04 13.8 0.0 1.7 1 0 0 1 1 1 0 IrrE N-terminal-like domain DUF5463 PF17551.2 ACT00773.1 - 0.021 14.7 0.8 0.037 13.9 0.8 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5463) DUF4131 PF13567.6 ACT00773.1 - 0.021 14.5 3.9 0.024 14.3 3.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) YrhC PF14143.6 ACT00773.1 - 0.04 14.0 3.0 0.056 13.5 2.9 1.3 1 1 0 1 1 1 0 YrhC-like protein DUF3367 PF11847.8 ACT00773.1 - 0.093 10.6 0.3 0.087 10.7 0.3 1.0 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase OATP PF03137.20 ACT00773.1 - 0.12 10.6 3.3 0.13 10.5 3.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF202 PF02656.15 ACT00773.1 - 0.17 12.4 4.6 0.22 12.0 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Wzy_C PF04932.15 ACT00773.1 - 0.42 10.2 5.2 0.44 10.2 5.2 1.0 1 0 0 1 1 1 0 O-Antigen ligase Methyltransf_11 PF08241.12 ACT00775.1 - 1.1e-07 32.4 0.1 3.1e-06 27.7 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT00775.1 - 3.2e-05 24.6 0.1 0.0012 19.6 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ACT00775.1 - 0.013 14.9 0.0 0.24 10.7 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.15 ACT00775.1 - 0.2 11.3 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CSD PF00313.22 ACT00776.1 - 1.9e-30 104.5 1.3 2e-30 104.4 1.3 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 ACT00776.1 - 0.0022 17.6 0.2 0.003 17.2 0.2 1.6 1 1 0 1 1 1 1 Ribonuclease B OB domain S1 PF00575.23 ACT00776.1 - 0.05 14.0 0.0 0.058 13.7 0.0 1.2 1 0 0 1 1 1 0 S1 RNA binding domain MFS_1_like PF12832.7 ACT00777.1 - 1e-55 189.2 32.5 1.4e-55 188.7 32.5 1.2 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 ACT00777.1 - 1.8e-20 73.1 40.3 3.3e-20 72.3 32.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.16 ACT00777.1 - 1.4e-19 70.4 26.7 1.9e-19 69.9 26.7 1.1 1 0 0 1 1 1 1 Nucleoside H+ symporter DUF1514 PF07438.11 ACT00777.1 - 2.5 8.0 10.4 12 5.9 0.1 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1514) DUF4391 PF14335.6 ACT00778.1 - 0.011 15.5 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) DUF2600 PF10776.9 ACT00779.1 - 9.1e-142 471.7 0.1 1e-141 471.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2600) PFK PF00365.20 ACT00780.1 - 2.2e-108 361.9 3.7 2.6e-108 361.6 3.7 1.0 1 0 0 1 1 1 1 Phosphofructokinase DAGK_cat PF00781.24 ACT00780.1 - 0.052 13.2 0.5 0.3 10.7 0.1 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain ABC_membrane PF00664.23 ACT00781.1 - 1.7e-48 165.6 9.8 2.3e-48 165.2 9.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT00781.1 - 1.5e-32 112.9 0.0 2.8e-32 112.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT00781.1 - 0.00027 20.5 0.9 0.026 14.0 0.9 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_membrane_3 PF13748.6 ACT00781.1 - 0.00085 18.6 0.2 0.00085 18.6 0.2 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region AAA_23 PF13476.6 ACT00781.1 - 0.0033 17.9 0.1 0.0086 16.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 ACT00781.1 - 0.0044 16.8 0.0 0.012 15.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ACT00781.1 - 0.0044 16.9 0.0 0.038 13.8 0.0 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT00781.1 - 0.006 16.3 0.1 0.073 12.8 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT00781.1 - 0.0075 16.2 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ACT00781.1 - 0.01 16.1 0.5 0.091 13.0 0.0 2.5 3 0 0 3 3 3 0 AAA domain ABC_ATPase PF09818.9 ACT00781.1 - 0.061 12.1 0.1 8.9 5.0 0.0 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_16 PF13191.6 ACT00781.1 - 0.074 13.4 0.0 0.18 12.2 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.22 ACT00781.1 - 0.097 12.3 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain SbcCD_C PF13558.6 ACT00781.1 - 0.17 12.2 0.2 1.4 9.2 0.2 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Response_reg PF00072.24 ACT00782.1 - 2.5e-31 108.1 0.2 3.5e-31 107.7 0.2 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT00782.1 - 1.7e-22 79.2 0.0 3e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal TAT_ubiq PF07706.12 ACT00782.1 - 0.072 13.3 0.1 2.5 8.4 0.0 2.5 2 0 0 2 2 2 0 Aminotransferase ubiquitination site HATPase_c PF02518.26 ACT00783.1 - 6e-29 100.8 0.4 1.1e-28 100.0 0.4 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT00783.1 - 3e-17 62.4 0.7 1.5e-16 60.2 0.6 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ACT00783.1 - 8e-05 22.5 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT00783.1 - 0.00011 22.0 0.0 0.00021 21.1 0.0 1.4 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 ACT00783.1 - 0.035 14.1 0.0 0.067 13.2 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c PF02518.26 ACT00784.1 - 4.2e-24 85.2 0.0 6.6e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT00784.1 - 4.2e-15 55.5 0.0 1.1e-14 54.2 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT00784.1 - 7.4e-14 51.9 0.0 1.3e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 HAMP domain HATPase_c_5 PF14501.6 ACT00784.1 - 1.8e-06 27.8 0.0 4.3e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 ACT00784.1 - 0.063 13.1 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT00784.1 - 0.09 12.7 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Trans_reg_C PF00486.28 ACT00785.1 - 6.9e-28 96.5 0.0 1.4e-27 95.6 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 ACT00785.1 - 3.2e-26 91.7 0.0 5e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain ACR_tran PF00873.19 ACT00786.1 - 7.5e-218 725.8 39.0 1e-217 725.3 39.0 1.2 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 ACT00786.1 - 2.7e-11 43.0 44.4 9.2e-07 28.1 24.8 2.8 2 1 0 2 2 2 2 MMPL family SecD_SecF PF02355.16 ACT00786.1 - 3.9e-11 42.7 38.9 1.9e-06 27.4 11.9 2.7 2 0 0 2 2 2 2 Protein export membrane protein DUF3213 PF11491.8 ACT00786.1 - 0.0026 17.9 0.1 0.64 10.2 0.0 3.8 3 1 0 3 3 3 1 Protein of unknown function (DUF3213) DUF4015 PF13200.6 ACT00787.1 - 1.9e-127 424.6 0.1 2.2e-127 424.4 0.1 1.0 1 0 0 1 1 1 1 Putative glycosyl hydrolase domain GHL6 PF14871.6 ACT00787.1 - 0.005 17.0 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase 6 GHL10 PF02638.15 ACT00787.1 - 0.012 14.8 0.1 0.03 13.4 0.1 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase-like 10 YitT_membrane PF02588.15 ACT00789.1 - 7.8e-57 192.0 23.4 9.5e-57 191.7 23.4 1.1 1 0 0 1 1 1 1 Uncharacterised 5xTM membrane BCR, YitT family COG1284 DUF2179 PF10035.9 ACT00789.1 - 9.7e-19 66.9 4.5 2.7e-17 62.2 0.6 2.6 3 0 0 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2179) DEAD PF00270.29 ACT00790.1 - 5.8e-52 176.0 0.2 1.1e-51 175.0 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ACT00790.1 - 1.3e-35 122.1 0.1 6.2e-34 116.7 0.0 3.0 2 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT00790.1 - 0.00013 22.0 0.0 0.00023 21.2 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 ACT00790.1 - 0.0039 16.0 0.0 0.74 8.5 0.0 2.9 3 0 0 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 ACT00790.1 - 0.0054 16.1 0.3 0.027 13.8 0.1 2.3 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 ACT00790.1 - 0.014 15.3 0.0 0.032 14.1 0.0 1.6 1 1 0 1 1 1 0 Helicase ANF_receptor PF01094.28 ACT00790.1 - 0.089 11.9 0.0 0.13 11.3 0.0 1.4 1 1 0 1 1 1 0 Receptor family ligand binding region AAA_22 PF13401.6 ACT00790.1 - 0.18 12.1 1.1 0.65 10.3 0.0 2.4 3 0 0 3 3 3 0 AAA domain DUF624 PF04854.14 ACT00791.1 - 6.1e-23 80.7 6.8 6.1e-23 80.7 6.8 2.9 2 2 0 2 2 2 1 Protein of unknown function, DUF624 ATP-synt_I PF03899.15 ACT00791.1 - 0.0022 18.3 0.1 0.0022 18.3 0.1 3.7 1 1 3 4 4 4 1 ATP synthase I chain SieB PF14163.6 ACT00791.1 - 0.053 13.0 0.2 0.053 13.0 0.2 2.2 1 1 1 2 2 2 0 Super-infection exclusion protein B Syndecan PF01034.20 ACT00791.1 - 0.38 10.7 0.1 0.38 10.7 0.1 3.2 3 0 0 3 3 3 0 Syndecan domain DUF1499 PF07386.11 ACT00792.1 - 1.6e-06 28.6 0.0 2e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1499) Redoxin PF08534.10 ACT00793.1 - 4.3e-25 88.1 0.1 5.3e-25 87.9 0.1 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ACT00793.1 - 1e-22 80.3 0.1 1.3e-22 80.0 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Rhomboid PF01694.22 ACT00794.1 - 3.8e-32 111.4 10.7 3.8e-32 111.4 10.7 1.6 2 0 0 2 2 2 1 Rhomboid family DUF1751 PF08551.10 ACT00794.1 - 6.1e-05 23.5 0.6 6.1e-05 23.5 0.6 2.3 2 1 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) DER1 PF04511.15 ACT00794.1 - 0.0022 17.9 1.0 0.0042 17.1 0.8 1.6 1 1 0 1 1 1 1 Der1-like family Colicin_V PF02674.16 ACT00794.1 - 1.1 9.2 14.0 0.26 11.3 3.3 2.8 2 1 1 3 3 3 0 Colicin V production protein Form_Nir_trans PF01226.17 ACT00794.1 - 5.2 6.3 11.5 0.17 11.2 2.1 2.2 2 0 0 2 2 2 0 Formate/nitrite transporter LysR_substrate PF03466.20 ACT00795.1 - 5e-47 160.0 0.0 8e-47 159.3 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT00795.1 - 1.7e-22 79.1 0.3 3.1e-22 78.3 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 ACT00795.1 - 0.011 15.5 0.1 0.022 14.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 ACT00795.1 - 0.018 14.9 0.1 0.045 13.6 0.0 1.7 2 0 0 2 2 2 0 MarR family MarR PF01047.22 ACT00795.1 - 0.058 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 MarR family HTH_23 PF13384.6 ACT00795.1 - 0.14 12.0 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_30 PF13556.6 ACT00795.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_11 PF08279.12 ACT00795.1 - 0.17 11.8 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 HTH domain Zn_peptidase_2 PF04298.12 ACT00796.1 - 5.6e-86 287.5 1.4 6.3e-86 287.3 1.4 1.0 1 0 0 1 1 1 1 Putative neutral zinc metallopeptidase MerR_1 PF13411.6 ACT00797.1 - 3.2e-21 75.2 0.8 1.1e-20 73.5 0.3 1.9 2 0 0 2 2 2 1 MerR HTH family regulatory protein MerR PF00376.23 ACT00797.1 - 2.4e-14 52.8 0.4 4.2e-14 52.0 0.4 1.4 1 0 0 1 1 1 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT00797.1 - 0.00028 21.3 0.2 0.00044 20.7 0.2 1.3 1 0 0 1 1 1 1 MerR, DNA binding Kre28 PF17097.5 ACT00797.1 - 0.0021 17.1 1.8 0.0024 16.9 1.8 1.0 1 0 0 1 1 1 1 Spindle pole body component DHR10 PF18595.1 ACT00797.1 - 0.016 15.3 4.4 0.037 14.1 4.0 1.7 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain MerR_2 PF13591.6 ACT00797.1 - 0.028 14.3 0.2 0.16 11.8 0.0 2.1 2 0 0 2 2 2 0 MerR HTH family regulatory protein BLOC1_2 PF10046.9 ACT00797.1 - 0.031 14.6 3.7 1.3 9.4 0.4 2.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TBCA PF02970.16 ACT00797.1 - 0.032 14.6 5.4 0.19 12.1 5.4 1.9 1 1 0 1 1 1 0 Tubulin binding cofactor A DUF4127 PF13552.6 ACT00797.1 - 0.059 12.0 1.1 0.066 11.8 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) DUF148 PF02520.17 ACT00797.1 - 0.074 13.2 0.5 0.11 12.7 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF148 Syntaxin-6_N PF09177.11 ACT00797.1 - 0.075 13.6 1.7 0.22 12.1 1.8 1.7 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Cauli_AT PF03233.13 ACT00797.1 - 0.15 12.0 2.4 0.71 9.8 2.4 1.8 1 1 0 1 1 1 0 Aphid transmission protein NPV_P10 PF05531.12 ACT00797.1 - 0.15 12.5 0.7 2.2 8.8 0.3 2.0 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.15 ACT00797.1 - 0.16 11.8 0.3 0.16 11.8 0.3 1.7 2 0 0 2 2 2 0 Septum formation initiator Prefoldin_2 PF01920.20 ACT00797.1 - 0.3 11.1 5.1 0.47 10.4 1.4 2.1 1 1 1 2 2 2 0 Prefoldin subunit Ammonium_transp PF00909.21 ACT00798.1 - 1.1e-111 373.4 40.7 1.3e-111 373.2 40.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF2070 PF09843.9 ACT00798.1 - 8.2 4.6 15.3 0.016 13.6 1.6 2.2 1 1 0 2 2 2 0 Predicted membrane protein (DUF2070) DUF294 PF03445.13 ACT00799.1 - 3.7e-37 127.2 0.0 6.6e-37 126.4 0.0 1.4 1 0 0 1 1 1 1 Putative nucleotidyltransferase DUF294 DUF294_C PF10335.9 ACT00799.1 - 1.2e-29 103.0 1.3 1.7e-29 102.5 1.3 1.3 1 0 0 1 1 1 1 Putative nucleotidyltransferase substrate binding domain Polbeta PF18765.1 ACT00799.1 - 0.056 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase TubC_N PF18563.1 ACT00799.1 - 0.1 12.6 0.1 0.27 11.2 0.1 1.7 1 0 0 1 1 1 0 TubC N-terminal docking domain RNase_T PF00929.24 ACT00800.1 - 2.6e-31 109.4 0.0 3.3e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 ACT00800.1 - 2.1e-08 34.3 0.0 3.7e-08 33.5 0.0 1.4 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like RNase_H_2 PF13482.6 ACT00800.1 - 0.00046 20.2 0.0 0.0013 18.8 0.0 1.7 1 1 0 1 1 1 1 RNase_H superfamily Prok-JAB PF14464.6 ACT00801.1 - 1.5e-14 53.8 0.1 1.7e-14 53.6 0.1 1.1 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain JAB PF01398.21 ACT00801.1 - 9.6e-05 22.4 0.0 0.00014 21.9 0.0 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MFS_1 PF07690.16 ACT00802.1 - 4.1e-50 170.7 37.7 3.7e-37 128.1 17.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT00802.1 - 2.9e-09 36.3 24.1 4.4e-05 22.5 2.2 3.2 2 1 1 3 3 3 3 Sugar (and other) transporter TRI12 PF06609.13 ACT00802.1 - 7.7e-07 27.9 2.6 7.7e-07 27.9 2.6 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 ACT00802.1 - 0.001 17.6 3.1 0.001 17.6 3.1 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector OATP PF03137.20 ACT00802.1 - 0.3 9.3 12.3 0.19 9.9 0.2 3.6 1 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Strabismus PF06638.11 ACT00802.1 - 0.39 9.3 7.1 0.14 10.8 0.7 2.1 2 0 0 2 2 2 0 Strabismus protein INSIG PF07281.12 ACT00802.1 - 1.6 8.3 5.7 11 5.6 0.3 2.9 2 1 1 3 3 3 0 Insulin-induced protein (INSIG) DUF2070 PF09843.9 ACT00802.1 - 3 6.0 20.8 2.3 6.4 8.3 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) AhpC-TSA PF00578.21 ACT00803.1 - 5.3e-22 78.1 0.0 6.8e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ACT00803.1 - 8.9e-20 70.9 0.0 1.2e-19 70.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin PF00085.20 ACT00803.1 - 1.2e-13 50.9 0.1 9.9e-11 41.5 0.1 2.2 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_8 PF13905.6 ACT00803.1 - 1.3e-12 47.9 0.0 2.2e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 ACT00803.1 - 1.6e-08 35.0 0.0 2.5e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain Glyco_hydro_36C PF16874.5 ACT00803.1 - 0.0011 19.3 0.0 0.0018 18.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 C-terminal domain TraF PF13728.6 ACT00803.1 - 0.018 14.8 0.0 0.23 11.3 0.0 2.0 1 1 0 1 1 1 0 F plasmid transfer operon protein PLD_C PF12357.8 ACT00803.1 - 0.037 13.9 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 Phospholipase D C terminal HMGL-like PF00682.19 ACT00804.1 - 2.8e-50 171.4 0.0 1.7e-49 168.8 0.0 2.0 2 0 0 2 2 2 1 HMGL-like LeuA_dimer PF08502.10 ACT00804.1 - 1.6e-30 105.7 1.5 2.5e-30 105.1 1.0 1.6 2 0 0 2 2 2 1 LeuA allosteric (dimerisation) domain IMS PF00817.20 ACT00805.1 - 3.9e-49 166.5 0.0 8.5e-49 165.4 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 ACT00805.1 - 6e-26 91.5 1.3 1.4e-25 90.3 1.2 1.6 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain DUF1805 PF08827.11 ACT00805.1 - 9e-05 22.7 0.0 0.00024 21.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1805) IMS_HHH PF11798.8 ACT00805.1 - 0.00052 20.2 0.0 0.0012 19.0 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif Fer4_13 PF13370.6 ACT00806.1 - 7.9e-21 74.4 3.4 9.3e-21 74.1 3.4 1.1 1 0 0 1 1 1 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 ACT00806.1 - 7.3e-13 49.1 3.0 8.1e-13 48.9 3.0 1.0 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_2 PF12797.7 ACT00806.1 - 0.00048 20.1 3.6 0.0043 17.1 0.5 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4 PF00037.27 ACT00806.1 - 0.032 14.0 1.4 0.032 14.0 1.4 2.5 2 1 1 3 3 3 0 4Fe-4S binding domain Fer4_6 PF12837.7 ACT00806.1 - 0.05 13.7 5.1 0.27 11.4 0.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_21 PF14697.6 ACT00806.1 - 0.16 12.2 4.9 1.2 9.3 4.9 2.0 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 ACT00806.1 - 0.7 10.6 6.7 1.3 9.7 1.3 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain DHO_dh PF01180.21 ACT00808.1 - 6e-93 311.3 0.0 6.9e-93 311.1 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 ACT00808.1 - 0.0015 18.0 0.0 0.0046 16.4 0.0 1.7 2 0 0 2 2 2 1 Nitronate monooxygenase DUF4995 PF16386.5 ACT00808.1 - 0.2 11.7 0.0 0.37 10.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function RelA_SpoT PF04607.17 ACT00809.1 - 6.9e-36 123.1 0.6 1.3e-35 122.2 0.6 1.5 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins RHH_5 PF07878.11 ACT00809.1 - 0.086 12.7 0.2 0.29 11.1 0.2 1.9 1 0 0 1 1 1 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 Peripla_BP_3 PF13377.6 ACT00810.1 - 2.3e-33 115.9 0.0 4.5e-33 114.9 0.0 1.5 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT00810.1 - 2e-17 63.5 0.0 2.7e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT00810.1 - 6.3e-13 48.3 0.1 1.2e-12 47.4 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACT00810.1 - 6.3e-05 22.7 0.0 0.0037 16.9 0.0 2.7 1 1 0 2 2 2 1 Periplasmic binding protein domain HTH_Crp_2 PF13545.6 ACT00810.1 - 0.0012 18.8 0.1 0.0057 16.6 0.0 2.2 1 1 1 2 2 2 1 Crp-like helix-turn-helix domain Sigma70_r4_2 PF08281.12 ACT00810.1 - 0.0023 17.6 0.2 0.74 9.5 0.0 2.5 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_38 PF13936.6 ACT00810.1 - 0.003 17.3 0.0 0.078 12.8 0.0 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_10 PF04967.12 ACT00810.1 - 0.0051 16.6 0.1 0.083 12.7 0.0 2.4 2 0 0 2 2 2 1 HTH DNA binding domain HTH_11 PF08279.12 ACT00810.1 - 0.0077 16.2 0.2 0.032 14.2 0.0 2.2 2 0 0 2 2 2 1 HTH domain HTH_24 PF13412.6 ACT00810.1 - 0.013 15.0 0.1 0.11 12.1 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding TetR_N PF00440.23 ACT00810.1 - 0.015 15.0 0.0 0.053 13.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family HTH_23 PF13384.6 ACT00810.1 - 0.024 14.4 0.0 0.86 9.5 0.0 2.7 2 1 1 3 3 2 0 Homeodomain-like domain SpoIIID PF12116.8 ACT00810.1 - 0.034 14.3 0.1 0.082 13.0 0.1 1.7 1 0 0 1 1 1 0 Stage III sporulation protein D Fe_dep_repress PF01325.19 ACT00810.1 - 0.048 13.9 0.2 0.46 10.7 0.1 2.4 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain GntR PF00392.21 ACT00810.1 - 0.11 12.1 0.1 2.2 8.0 0.0 2.5 1 1 0 2 2 2 0 Bacterial regulatory proteins, gntR family HTH_36 PF13730.6 ACT00810.1 - 0.12 12.3 0.2 2.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Phage_terminase PF10668.9 ACT00810.1 - 0.13 12.2 0.1 0.31 11.1 0.1 1.6 1 1 0 1 1 1 0 Phage terminase small subunit GlcNAc_2-epim PF07221.11 ACT00811.1 - 2.8e-45 155.1 7.2 3.6e-45 154.7 7.2 1.1 1 0 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) C5-epim_C PF06662.13 ACT00811.1 - 3.4e-06 26.7 0.7 0.01 15.4 0.1 2.5 2 0 0 2 2 2 2 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.13 ACT00811.1 - 2.7e-05 23.4 8.7 0.0017 17.5 1.1 2.8 1 1 2 3 3 3 2 Glycosyl Hydrolase Family 88 LANC_like PF05147.13 ACT00811.1 - 0.0044 15.6 0.4 0.37 9.3 0.0 2.6 3 0 0 3 3 3 2 Lanthionine synthetase C-like protein Glyco_hydro_76 PF03663.14 ACT00811.1 - 0.0075 15.8 11.3 0.017 14.7 1.3 2.3 1 1 0 2 2 2 2 Glycosyl hydrolase family 76 Glyco_hydro_127 PF07944.12 ACT00811.1 - 0.0076 14.8 2.4 0.014 14.0 0.3 2.0 1 1 0 2 2 2 1 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_130 PF04041.13 ACT00812.1 - 2.7e-22 79.1 0.0 3.6e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 beta-1,4-mannooligosaccharide phosphorylase DUF1861 PF08950.10 ACT00812.1 - 0.00032 20.1 0.0 0.00092 18.5 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1861) Glyco_hydro_43 PF04616.14 ACT00812.1 - 0.012 15.0 0.0 0.38 10.0 0.0 2.3 2 0 0 2 2 2 0 Glycosyl hydrolases family 43 AXE1 PF05448.12 ACT00813.1 - 4.1e-134 446.2 0.0 4.6e-134 446.1 0.0 1.0 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 ACT00813.1 - 3.4e-09 36.5 0.0 6.2e-08 32.4 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ACT00813.1 - 4.1e-08 32.8 0.8 0.0084 15.4 0.0 2.8 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 ACT00813.1 - 1.1e-05 25.2 0.0 0.0067 16.0 0.1 2.7 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 ACT00813.1 - 1.2e-05 25.0 0.0 4.2e-05 23.2 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 ACT00813.1 - 0.00024 21.8 3.1 0.00024 21.8 3.1 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ACT00813.1 - 0.018 14.7 0.3 0.1 12.2 0.3 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.11 ACT00813.1 - 0.019 14.9 0.0 0.12 12.3 0.0 2.0 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Det1 PF09737.9 ACT00813.1 - 0.19 10.7 0.0 0.26 10.3 0.0 1.1 1 0 0 1 1 1 0 De-etiolated protein 1 Det1 MarR PF01047.22 ACT00814.1 - 3e-13 49.5 0.1 4.7e-13 48.9 0.1 1.3 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT00814.1 - 4e-08 33.0 0.1 9.4e-08 31.8 0.0 1.6 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 ACT00814.1 - 1e-05 25.9 0.1 2.3e-05 24.8 0.1 1.6 1 1 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.6 ACT00814.1 - 1.8e-05 24.2 0.2 4.4e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding DUF2250 PF10007.9 ACT00814.1 - 0.00037 20.5 0.0 0.00064 19.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2250) DprA_WH PF17782.1 ACT00814.1 - 0.00072 19.6 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 DprA winged helix domain HTH_20 PF12840.7 ACT00814.1 - 0.0017 18.4 0.1 0.0042 17.1 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_5 PF01022.20 ACT00814.1 - 0.0021 17.9 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family RNA_pol_Rpc34 PF05158.12 ACT00814.1 - 0.0025 17.3 0.1 0.0034 16.8 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit HTH_36 PF13730.6 ACT00814.1 - 0.0089 16.0 0.2 0.029 14.3 0.1 1.8 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_IclR PF09339.10 ACT00814.1 - 0.0095 15.7 0.2 0.017 14.9 0.2 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_11 PF08279.12 ACT00814.1 - 0.012 15.6 0.1 0.021 14.8 0.1 1.4 1 0 0 1 1 1 0 HTH domain FeoC PF09012.10 ACT00814.1 - 0.019 15.1 0.0 0.036 14.1 0.0 1.4 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_Crp_2 PF13545.6 ACT00814.1 - 0.019 14.9 0.1 0.045 13.7 0.1 1.8 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Phage_rep_org_N PF09681.10 ACT00814.1 - 0.021 14.8 0.0 0.038 13.9 0.0 1.5 1 1 0 1 1 1 0 N-terminal phage replisome organiser (Phage_rep_org_N) TrmB PF01978.19 ACT00814.1 - 0.024 14.5 0.0 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_39 PF14090.6 ACT00814.1 - 0.041 13.6 0.0 0.072 12.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DUF501 PF04417.12 ACT00814.1 - 0.05 13.4 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF501) ABC2_membrane_3 PF12698.7 ACT00815.1 - 3.9e-14 52.5 8.6 5.3e-14 52.1 8.6 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 ACT00815.1 - 2.4e-09 37.0 13.0 2.4e-09 37.0 13.0 2.0 1 1 1 2 2 2 1 ABC-2 type transporter DASH_Dad2 PF08654.10 ACT00815.1 - 0.0086 16.5 5.6 0.016 15.6 1.6 3.1 2 2 2 4 4 4 1 DASH complex subunit Dad2 Laminin_I PF06008.14 ACT00815.1 - 0.038 13.7 4.3 0.61 9.7 0.9 2.2 2 0 0 2 2 2 0 Laminin Domain I Sec34 PF04136.15 ACT00815.1 - 0.1 12.5 0.8 20 5.1 0.1 3.2 2 2 1 3 3 3 0 Sec34-like family LemA PF04011.12 ACT00815.1 - 0.14 12.0 0.3 0.31 10.9 0.3 1.5 1 0 0 1 1 1 0 LemA family PDR_CDR PF06422.12 ACT00815.1 - 0.16 11.9 0.1 0.16 11.9 0.1 1.9 2 0 0 2 2 1 0 CDR ABC transporter CENP-F_leu_zip PF10473.9 ACT00815.1 - 0.22 11.5 1.3 0.71 9.9 0.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Phage_Mu_Gam PF07352.12 ACT00815.1 - 0.22 11.4 4.2 0.058 13.3 0.8 1.9 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein Laminin_II PF06009.12 ACT00815.1 - 0.61 10.1 4.7 1.4 9.0 2.2 2.5 2 1 0 2 2 2 0 Laminin Domain II ZapB PF06005.12 ACT00815.1 - 1.7 9.1 3.7 44 4.6 0.5 3.5 2 2 0 2 2 2 0 Cell division protein ZapB DUF3450 PF11932.8 ACT00815.1 - 2.5 7.4 12.8 2 7.6 3.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 ACT00815.1 - 3.1 8.3 5.0 8.1 7.0 0.8 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF2070 PF09843.9 ACT00815.1 - 4.1 5.6 10.0 7.5 4.7 10.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) FeoB_C PF07664.12 ACT00815.1 - 7.4 6.3 6.8 1.8 8.3 0.5 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B C terminus DUF883 PF05957.13 ACT00815.1 - 8.9 7.0 11.7 0.43 11.2 1.0 3.4 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Pribosyltran PF00156.27 ACT00816.1 - 5.5e-09 35.7 0.1 1.4e-08 34.4 0.1 1.6 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Eno-Rase_NADH_b PF12242.8 ACT00816.1 - 0.021 14.6 0.2 0.044 13.5 0.2 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Pyr_redox_2 PF07992.14 ACT00817.1 - 8e-61 205.8 1.4 8e-61 205.8 1.4 1.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT00817.1 - 1.7e-20 73.4 2.8 6.5e-19 68.3 0.4 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ACT00817.1 - 2.1e-17 63.4 0.4 8.7e-17 61.4 0.0 2.3 3 0 0 3 3 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 ACT00817.1 - 1.7e-09 37.4 0.3 4.1e-09 36.1 0.1 1.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT00817.1 - 5.5e-09 36.1 1.7 0.00019 21.2 0.0 3.6 3 1 1 4 4 4 2 FAD dependent oxidoreductase HI0933_like PF03486.14 ACT00817.1 - 2.1e-07 30.0 0.2 0.19 10.4 0.0 3.6 4 0 0 4 4 4 3 HI0933-like protein K_oxygenase PF13434.6 ACT00817.1 - 3.1e-06 26.6 0.1 5.2e-05 22.5 0.0 2.4 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) UDPG_MGDP_dh_N PF03721.14 ACT00817.1 - 1.5e-05 24.6 0.5 0.00019 21.1 0.1 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 ACT00817.1 - 0.00019 21.6 0.5 0.012 15.9 0.1 3.0 3 0 0 3 3 3 1 TrkA-N domain AlaDh_PNT_C PF01262.21 ACT00817.1 - 0.00097 18.5 0.9 0.023 14.0 0.1 2.5 2 1 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain DRTGG PF07085.12 ACT00817.1 - 0.0015 18.3 0.8 0.013 15.3 0.1 2.6 3 0 0 3 3 3 1 DRTGG domain NAD_binding_9 PF13454.6 ACT00817.1 - 0.0022 18.0 0.7 0.32 11.0 0.0 3.5 3 1 1 4 4 4 1 FAD-NAD(P)-binding 3HCDH_N PF02737.18 ACT00817.1 - 0.0025 17.7 0.2 0.0087 16.0 0.1 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ACT00817.1 - 0.0034 17.9 0.1 0.79 10.3 0.1 3.5 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent XdhC_C PF13478.6 ACT00817.1 - 0.0088 16.5 0.0 0.075 13.5 0.0 2.6 2 1 0 2 2 2 1 XdhC Rossmann domain GIDA PF01134.22 ACT00817.1 - 0.013 14.6 3.5 2.7 7.0 0.2 3.2 2 2 2 4 4 4 0 Glucose inhibited division protein A NAD_binding_7 PF13241.6 ACT00817.1 - 0.021 15.3 0.3 0.24 11.9 0.0 2.4 1 1 1 2 2 2 0 Putative NAD(P)-binding NAD_binding_8 PF13450.6 ACT00817.1 - 0.027 14.7 0.1 4.3 7.6 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ACT00817.1 - 0.034 13.5 0.0 5.7 6.1 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase 2-Hacid_dh_C PF02826.19 ACT00817.1 - 0.034 13.5 0.1 0.17 11.2 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IGR PF09597.10 ACT00817.1 - 0.14 12.3 0.0 5 7.3 0.0 2.4 2 0 0 2 2 2 0 IGR protein motif Shikimate_DH PF01488.20 ACT00817.1 - 0.19 11.8 1.0 3.5 7.7 0.0 3.0 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase Methyltr_RsmB-F PF01189.17 ACT00818.1 - 2.1e-45 154.8 0.0 3.3e-45 154.2 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 ACT00818.1 - 5.8e-33 113.3 0.0 1.1e-32 112.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltranf_PUA PF13636.6 ACT00818.1 - 4.2e-22 77.9 0.5 7.8e-22 77.0 0.5 1.5 1 0 0 1 1 1 1 RNA-binding PUA-like domain of methyltransferase RsmF RsmF_methylt_CI PF17126.5 ACT00818.1 - 2.3e-20 72.4 0.0 5.7e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 RsmF rRNA methyltransferase first C-terminal domain FtsJ PF01728.19 ACT00818.1 - 0.00012 22.2 0.0 0.00023 21.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 ACT00818.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain F_actin_bund_C PF18060.1 ACT00818.1 - 0.15 12.2 3.8 1.2 9.3 1.3 2.3 2 0 0 2 2 2 0 F actin bundling C terminal PseudoU_synth_2 PF00849.22 ACT00819.1 - 8.3e-21 74.7 0.0 1.4e-20 74.0 0.0 1.4 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 ACT00819.1 - 5.8e-13 48.3 0.1 1.1e-12 47.4 0.1 1.4 1 0 0 1 1 1 1 S4 domain Hydrolase_3 PF08282.12 ACT00820.1 - 4.5e-58 197.0 0.0 5.1e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ACT00820.1 - 6.3e-13 48.8 0.0 1.4e-06 28.0 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.7 ACT00820.1 - 2.8e-06 27.9 4.7 0.01 16.3 0.0 3.2 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT00820.1 - 7.3e-06 26.4 0.5 0.6 10.4 0.0 3.2 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ACT00820.1 - 0.039 14.0 0.0 0.08 13.1 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase PHTB1_C PF14728.6 ACT00820.1 - 0.066 12.3 0.0 0.088 11.9 0.0 1.1 1 0 0 1 1 1 0 PTHB1 C-terminus YjcZ_2 PF09680.10 ACT00821.1 - 0.23 11.2 14.5 0.29 10.8 14.5 1.4 1 1 0 1 1 1 0 Family of unknown function Methyltr_RsmB-F PF01189.17 ACT00822.1 - 4.7e-45 153.7 0.0 2.3e-44 151.4 0.0 1.9 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 ACT00822.1 - 4.2e-33 113.7 0.1 8.7e-33 112.7 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF RsmF_methylt_CI PF17126.5 ACT00822.1 - 7.7e-21 73.9 0.1 1.5e-20 73.0 0.1 1.5 1 0 0 1 1 1 1 RsmF rRNA methyltransferase first C-terminal domain Methyltranf_PUA PF13636.6 ACT00822.1 - 2.7e-20 72.1 0.1 4.9e-20 71.3 0.1 1.5 1 0 0 1 1 1 1 RNA-binding PUA-like domain of methyltransferase RsmF Methyltransf_31 PF13847.6 ACT00822.1 - 0.0038 17.0 0.0 0.0059 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ACT00822.1 - 0.079 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein FtsJ PF01728.19 ACT00822.1 - 0.09 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase DEAD PF00270.29 ACT00823.1 - 2e-51 174.3 1.4 2e-51 174.3 1.4 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ACT00823.1 - 1.3e-30 106.0 0.5 2.7e-29 101.8 0.1 2.6 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT00823.1 - 2.1e-07 31.1 0.0 4.4e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ACT00823.1 - 0.016 14.6 1.0 0.32 10.3 0.0 2.3 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit SecA_DEAD PF07517.14 ACT00823.1 - 0.11 11.8 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain AAA_22 PF13401.6 ACT00823.1 - 0.12 12.7 0.1 0.34 11.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain DUF2196 PF09962.9 ACT00824.1 - 6.1e-33 112.6 2.3 6.7e-33 112.5 2.3 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) DUF4031 PF13223.6 ACT00825.1 - 0.12 12.7 0.0 0.19 11.9 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4031) Acetyltransf_1 PF00583.25 ACT00826.1 - 1.2e-12 48.1 0.0 3.6e-12 46.6 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ACT00826.1 - 1.2e-08 34.8 0.0 2e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 ACT00826.1 - 1.9e-07 31.4 0.3 4.1e-07 30.3 0.1 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT00826.1 - 0.00025 21.0 0.0 0.00058 19.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 ACT00826.1 - 0.00076 19.7 0.0 0.0012 19.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ACT00826.1 - 0.0097 15.4 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Putative acetyl-transferase DUF4439 PF14530.6 ACT00826.1 - 0.047 14.4 0.0 0.23 12.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4439) LysE PF01810.18 ACT00827.1 - 1.1e-26 93.5 11.9 1.3e-26 93.3 11.9 1.1 1 0 0 1 1 1 1 LysE type translocator PSII_Ycf12 PF05969.11 ACT00827.1 - 4.6 7.3 6.7 27 4.9 0.2 3.1 3 0 0 3 3 3 0 Photosystem II complex subunit Ycf12 Lip_prot_lig_C PF10437.9 ACT00829.1 - 5e-25 87.3 0.2 2.5e-24 85.1 0.0 2.2 3 0 0 3 3 3 1 Bacterial lipoate protein ligase C-terminus BPL_LplA_LipB PF03099.19 ACT00829.1 - 1.8e-10 40.8 0.0 5.3e-10 39.3 0.0 1.7 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family MoeA_N PF03453.17 ACT00830.1 - 5.2e-39 133.5 0.1 1e-38 132.6 0.1 1.5 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 ACT00830.1 - 1.5e-23 83.1 0.0 3.4e-23 81.9 0.0 1.6 2 0 0 2 2 2 1 Probable molybdopterin binding domain MoeA_C PF03454.15 ACT00830.1 - 3.5e-12 46.3 0.0 2.2e-11 43.7 0.0 2.4 2 0 0 2 2 2 1 MoeA C-terminal region (domain IV) Pyr_redox_2 PF07992.14 ACT00831.1 - 2.1e-58 197.9 0.1 4.5e-58 196.8 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 ACT00831.1 - 3.9e-25 87.6 0.3 1.3e-24 85.9 0.3 2.0 1 0 0 1 1 1 1 Rubredoxin NAD+ reductase C-terminal domain Fer2_BFD PF04324.15 ACT00831.1 - 2.2e-19 69.5 10.2 2.6e-13 50.1 4.7 2.5 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Pyr_redox PF00070.27 ACT00831.1 - 8.7e-19 67.9 0.9 7.7e-16 58.4 0.1 3.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACT00831.1 - 2.7e-10 40.0 0.0 5.8e-10 38.9 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 ACT00831.1 - 4.2e-08 32.9 0.0 7.8e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain NAD_binding_9 PF13454.6 ACT00831.1 - 4.9e-05 23.4 2.1 12 5.9 0.0 4.4 3 1 1 4 4 4 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 ACT00831.1 - 0.0025 17.1 0.3 0.016 14.5 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 ACT00831.1 - 0.0026 18.2 0.2 0.11 12.9 0.0 3.0 3 0 0 3 3 3 1 Putative NAD(P)-binding GIDA PF01134.22 ACT00831.1 - 0.0076 15.4 3.7 0.2 10.7 0.4 3.6 3 1 1 4 4 4 1 Glucose inhibited division protein A 3HCDH_N PF02737.18 ACT00831.1 - 0.034 14.0 0.1 0.034 14.0 0.1 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K_oxygenase PF13434.6 ACT00831.1 - 0.077 12.1 0.0 0.2 10.8 0.0 1.7 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 ACT00831.1 - 0.17 10.9 6.6 1.8 7.5 0.1 2.9 3 0 0 3 3 3 0 FAD binding domain DAO PF01266.24 ACT00831.1 - 0.22 11.0 2.5 38 3.7 1.4 3.7 3 1 0 4 4 4 0 FAD dependent oxidoreductase Molybdopterin PF00384.22 ACT00832.1 - 8.6e-90 301.7 0.0 1.1e-89 301.4 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 ACT00832.1 - 2.2e-25 88.8 0.0 4.7e-25 87.8 0.0 1.6 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Molybdop_Fe4S4 PF04879.16 ACT00832.1 - 1e-10 41.4 1.1 2.2e-10 40.3 1.1 1.6 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Fe4S4 domain Phage_terminase PF10668.9 ACT00832.1 - 0.13 12.3 0.0 6.5 6.9 0.1 2.6 2 0 0 2 2 2 0 Phage terminase small subunit NTP_transf_3 PF12804.7 ACT00833.1 - 7e-35 120.7 0.1 8.1e-35 120.5 0.1 1.0 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 ACT00833.1 - 0.06 12.9 0.2 0.089 12.4 0.2 1.2 1 0 0 1 1 1 0 Nucleotidyl transferase IspD PF01128.19 ACT00833.1 - 0.14 11.9 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MobB PF03205.14 ACT00834.1 - 2.1e-30 105.3 0.0 2.6e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.19 ACT00834.1 - 0.0069 16.0 0.0 0.0098 15.5 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 ACT00834.1 - 0.012 15.7 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 ACT00834.1 - 0.02 13.9 0.0 0.031 13.3 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 ACT00834.1 - 0.028 14.3 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase NTPase_1 PF03266.15 ACT00834.1 - 0.032 14.1 0.0 0.091 12.7 0.0 1.7 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 ACT00834.1 - 0.032 14.3 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACT00834.1 - 0.085 13.0 0.0 0.21 11.7 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase CLP1_P PF16575.5 ACT00834.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF5316 PF17247.2 ACT00835.1 - 7.4e-12 45.1 0.1 8.3e-12 45.0 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5316) GWT1 PF06423.12 ACT00835.1 - 0.08 13.1 0.0 0.094 12.8 0.0 1.0 1 0 0 1 1 1 0 GWT1 OppC_N PF12911.7 ACT00835.1 - 0.42 10.6 2.6 1.9 8.6 1.6 2.0 1 1 1 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C HATPase_c PF02518.26 ACT00836.1 - 1.8e-20 73.5 0.2 2.9e-20 72.9 0.2 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT00836.1 - 9.5e-11 41.6 0.1 3.6e-10 39.7 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ACT00836.1 - 3.7e-07 30.0 0.1 7.4e-07 29.1 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT00836.1 - 0.00019 21.4 0.0 0.00039 20.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 ACT00836.1 - 0.002 18.0 0.1 0.0045 16.9 0.1 1.5 1 0 0 1 1 1 1 GHKL domain DUF4756 PF15948.5 ACT00836.1 - 0.07 13.0 0.6 0.15 11.9 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4756) Abhydrolase_1 PF00561.20 ACT00837.1 - 1.9e-08 34.3 0.0 2.4e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACT00837.1 - 7.4e-08 33.3 0.0 8.1e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACT00837.1 - 0.00067 19.0 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 MarR PF01047.22 ACT00838.1 - 2.1e-14 53.2 0.8 3.1e-14 52.7 0.1 1.7 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.7 ACT00838.1 - 3.5e-11 42.8 0.1 6.7e-11 41.9 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT00838.1 - 2.7e-10 40.6 0.0 4.5e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.6 ACT00838.1 - 0.00018 21.0 0.9 0.00033 20.2 0.2 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_34 PF13601.6 ACT00838.1 - 0.00039 20.6 0.0 0.00054 20.1 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain HxlR PF01638.17 ACT00838.1 - 0.00094 19.0 0.2 0.0015 18.3 0.2 1.3 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_20 PF12840.7 ACT00838.1 - 0.0018 18.3 0.1 0.0036 17.3 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_IclR PF09339.10 ACT00838.1 - 0.0041 16.9 0.2 0.012 15.4 0.2 1.8 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_11 PF08279.12 ACT00838.1 - 0.0049 16.8 0.1 0.01 15.8 0.1 1.5 1 0 0 1 1 1 1 HTH domain HTH_Crp_2 PF13545.6 ACT00838.1 - 0.0059 16.6 0.1 0.0091 16.0 0.1 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain RP-C PF03428.13 ACT00838.1 - 0.0095 15.6 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 Replication protein C N-terminal domain HTH_5 PF01022.20 ACT00838.1 - 0.015 15.1 2.0 0.015 15.1 2.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Fe_dep_repress PF01325.19 ACT00838.1 - 0.038 14.2 0.0 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_38 PF13936.6 ACT00838.1 - 0.07 12.9 0.0 0.17 11.7 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain DUF4423 PF14394.6 ACT00838.1 - 0.071 12.8 1.2 2.8 7.6 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4423) Dimerisation2 PF16864.5 ACT00838.1 - 0.092 12.7 0.1 0.2 11.7 0.1 1.6 1 0 0 1 1 1 0 Dimerisation domain TrmB PF01978.19 ACT00838.1 - 0.099 12.5 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB ArsB PF02040.15 ACT00839.1 - 1.8e-207 689.7 35.6 2.2e-207 689.4 35.6 1.0 1 0 0 1 1 1 1 Arsenical pump membrane protein CitMHS PF03600.16 ACT00839.1 - 1.8e-27 96.4 36.3 1.8e-27 96.4 36.3 2.1 1 1 1 2 2 2 1 Citrate transporter LMWPc PF01451.21 ACT00840.1 - 6.7e-23 81.6 0.0 7.9e-23 81.4 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase DUF5318 PF17249.2 ACT00840.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5318) LPAM_2 PF13627.6 ACT00842.1 - 0.013 15.4 1.8 0.019 14.8 1.8 1.3 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site ApoO PF09769.9 ACT00842.1 - 0.076 13.0 0.1 0.15 12.0 0.0 1.5 2 0 0 2 2 2 0 Apolipoprotein O GSP_synth PF03738.14 ACT00843.1 - 2.1e-88 297.1 0.0 2.5e-88 296.8 0.0 1.0 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp ATP-grasp_3 PF02655.14 ACT00843.1 - 0.033 14.2 0.0 0.072 13.1 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain DUF350 PF03994.14 ACT00844.1 - 9.5e-17 60.9 22.3 6.3e-12 45.5 2.3 3.0 2 1 0 2 2 2 2 Domain of Unknown Function (DUF350) CrgA PF06781.12 ACT00844.1 - 0.27 11.3 10.9 0.65 10.1 4.6 2.5 2 1 0 2 2 2 0 Cell division protein CrgA DUF3422 PF11902.8 ACT00844.1 - 0.43 9.6 2.4 0.61 9.1 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) DUF2304 PF10066.9 ACT00844.1 - 0.58 10.4 11.3 0.17 12.2 2.4 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2304) tRNA-synt_1 PF00133.22 ACT00845.1 - 5.7e-70 236.2 6.0 7.6e-49 166.5 4.4 4.9 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 ACT00845.1 - 6.4e-65 218.1 0.0 9.9e-65 217.5 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 ACT00845.1 - 1.5e-27 96.4 0.5 1.1e-17 63.9 0.0 4.2 4 1 1 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ACT00845.1 - 3.5e-20 72.5 0.5 2.5e-19 69.7 0.5 2.2 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 ACT00845.1 - 9.9e-06 25.1 0.1 0.012 15.0 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain Tim54 PF11711.8 ACT00845.1 - 0.095 11.5 0.2 0.49 9.1 0.0 1.9 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 TyrRSs_C PF16714.5 ACT00845.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Tyrosyl-tRNA synthetase C-terminal domain P5CR_dimer PF14748.6 ACT00846.1 - 5.6e-20 71.5 0.0 9.9e-20 70.7 0.0 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 ACT00846.1 - 3.9e-19 69.0 0.0 6.4e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ACT00846.1 - 9.5e-09 35.6 0.0 1.6e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 ACT00846.1 - 5.8e-08 32.9 0.0 9.2e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 ACT00846.1 - 0.00041 20.6 0.0 0.0007 19.9 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 ACT00846.1 - 0.0007 19.3 0.1 0.0023 17.6 0.1 1.8 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA GFO_IDH_MocA PF01408.22 ACT00846.1 - 0.12 13.2 0.0 0.22 12.4 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold 3HCDH_N PF02737.18 ACT00846.1 - 0.18 11.7 0.1 2.9 7.8 0.1 2.2 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HHH_3 PF12836.7 ACT00847.1 - 2.2e-19 69.5 0.0 3.1e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH PF00633.23 ACT00847.1 - 6.7e-10 38.3 0.2 3.4e-06 26.6 0.1 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_5 PF14520.6 ACT00847.1 - 4.5e-05 24.0 1.6 0.04 14.5 0.2 2.2 2 0 0 2 2 2 2 Helix-hairpin-helix domain HHH_6 PF14579.6 ACT00847.1 - 0.00021 21.5 0.0 0.00037 20.7 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif T2SSK PF03934.13 ACT00847.1 - 0.0048 16.3 0.0 0.0073 15.7 0.0 1.3 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein K HHH_2 PF12826.7 ACT00847.1 - 0.0072 16.4 0.1 0.33 11.1 0.1 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif Transposase_20 PF02371.16 ACT00847.1 - 0.14 12.5 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family Cys_Met_Meta_PP PF01053.20 ACT00848.1 - 2.9e-152 506.6 0.0 3.4e-152 506.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ACT00848.1 - 2.8e-13 49.9 0.1 7.5e-13 48.5 0.1 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 ACT00848.1 - 1.7e-08 34.1 0.0 2.8e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ACT00848.1 - 4.6e-08 32.4 0.0 9.1e-08 31.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ACT00848.1 - 0.00022 20.6 0.0 0.001 18.4 0.0 2.0 1 1 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 ACT00848.1 - 0.00033 19.6 0.0 0.00048 19.1 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein dCMP_cyt_deam_1 PF00383.23 ACT00849.1 - 1.9e-21 75.9 0.1 3.4e-21 75.0 0.1 1.4 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ACT00849.1 - 2.9e-15 56.2 0.0 4.4e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC_N PF08210.11 ACT00849.1 - 0.0023 17.9 0.0 0.0033 17.3 0.0 1.3 1 0 0 1 1 1 1 APOBEC-like N-terminal domain XOO_2897-deam PF14440.6 ACT00849.1 - 0.0025 17.9 0.0 0.0046 17.0 0.0 1.4 1 0 0 1 1 1 1 Xanthomonas XOO_2897-like deaminase Bd3614-deam PF14439.6 ACT00849.1 - 0.0027 17.8 0.4 0.076 13.1 0.0 2.3 1 1 1 2 2 2 1 Bd3614-like deaminase SNAD4 PF18750.1 ACT00849.1 - 0.0091 16.1 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 OTT_1508_deam PF14441.6 ACT00849.1 - 0.087 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 OTT_1508-like deaminase APOBEC4_like PF18774.1 ACT00849.1 - 0.098 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase NAD1 PF18778.1 ACT00849.1 - 0.14 12.3 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 Competence PF03772.16 ACT00850.1 - 6.6e-63 212.5 32.8 6.6e-63 212.5 32.8 2.3 3 0 0 3 3 3 1 Competence protein DUF4131 PF13567.6 ACT00850.1 - 8.8e-31 106.8 0.1 8.8e-31 106.8 0.1 3.7 4 1 0 4 4 4 2 Domain of unknown function (DUF4131) Lactamase_B PF00753.27 ACT00850.1 - 7.7e-08 32.6 0.1 2.5e-07 30.9 0.1 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ACT00850.1 - 0.0015 18.1 0.0 0.0041 16.7 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Sigma70_r4_2 PF08281.12 ACT00851.1 - 2.5e-18 65.5 0.0 5e-18 64.5 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACT00851.1 - 1.3e-15 56.9 0.2 3.5e-15 55.5 0.2 1.8 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 ACT00851.1 - 7.8e-13 47.7 0.0 1.3e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACT00851.1 - 8.9e-06 25.7 0.7 2.4e-05 24.3 0.7 1.7 1 1 0 1 1 1 1 ECF sigma factor HTH_23 PF13384.6 ACT00851.1 - 0.00038 20.2 0.0 0.0041 16.9 0.0 2.7 2 1 0 2 2 2 1 Homeodomain-like domain GerE PF00196.19 ACT00851.1 - 0.003 17.1 0.0 0.0066 16.0 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sipho_Gp157 PF05565.11 ACT00851.1 - 0.0095 16.0 0.8 0.014 15.4 0.8 1.2 1 0 0 1 1 1 1 Siphovirus Gp157 Terminase_5 PF06056.12 ACT00851.1 - 0.021 14.7 0.0 0.049 13.5 0.0 1.6 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) UPF0122 PF04297.14 ACT00851.1 - 0.03 14.5 0.8 0.11 12.7 0.1 2.1 1 1 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like HTH_40 PF14493.6 ACT00851.1 - 0.038 14.4 0.1 1 9.9 0.0 2.7 1 1 2 3 3 3 0 Helix-turn-helix domain DUF2795 PF11387.8 ACT00851.1 - 0.057 13.6 0.3 0.86 9.9 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2795) YliH PF10799.8 ACT00851.1 - 0.059 13.3 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Biofilm formation protein (YliH/bssR) HTH_28 PF13518.6 ACT00851.1 - 0.086 13.0 0.1 3.5 7.8 0.0 2.8 2 1 0 2 2 2 0 Helix-turn-helix domain FliT PF05400.13 ACT00851.1 - 0.18 12.7 3.1 0.32 11.8 0.5 2.6 3 1 0 3 3 2 0 Flagellar protein FliT zf-HC2 PF13490.6 ACT00852.1 - 1.3e-06 28.5 1.9 2.4e-06 27.6 1.9 1.5 1 0 0 1 1 1 1 Putative zinc-finger DNA_pol3_delta PF06144.13 ACT00853.1 - 2.8e-38 131.4 0.1 4e-38 130.9 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_33 PF13671.6 ACT00853.1 - 0.093 12.9 0.2 0.18 12.0 0.2 1.4 1 0 0 1 1 1 0 AAA domain Ribosomal_S20p PF01649.18 ACT00854.1 - 5.4e-28 97.4 16.2 6.1e-28 97.3 16.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S20 Peptidase_A25 PF03418.14 ACT00855.1 - 4.2e-127 423.9 8.4 2.5e-101 339.1 4.0 2.0 1 1 1 2 2 2 2 Germination protease DUF1256 PF06866.11 ACT00855.1 - 2.1e-05 24.0 0.2 0.06 12.7 0.2 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1256) SpoIIP PF07454.11 ACT00856.1 - 1.1e-74 251.3 0.0 1.4e-74 251.0 0.0 1.1 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Amidase_3 PF01520.18 ACT00856.1 - 0.00025 21.2 0.0 0.0004 20.6 0.0 1.2 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase OMS28_porin PF03532.13 ACT00857.1 - 0.029 13.6 0.0 0.087 12.0 0.0 1.7 2 0 0 2 2 2 0 OMS28 porin Sigma70_ner PF04546.13 ACT00857.1 - 0.047 13.6 0.7 0.063 13.1 0.7 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region WD40_alt PF14077.6 ACT00857.1 - 0.14 12.1 1.7 0.25 11.2 1.5 1.5 1 1 0 1 1 1 0 Alternative WD40 repeat motif Synaptobrevin PF00957.21 ACT00857.1 - 0.29 11.0 0.9 8.3 6.3 0.1 2.2 2 0 0 2 2 2 0 Synaptobrevin GTP_EFTU PF00009.27 ACT00858.1 - 8.5e-55 185.3 0.1 1.4e-54 184.6 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 ACT00858.1 - 1.7e-52 176.1 3.7 3e-52 175.3 3.7 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 ACT00858.1 - 4.9e-27 93.8 0.0 1.5e-26 92.2 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ACT00858.1 - 1.5e-10 41.3 3.7 1.5e-10 41.3 3.7 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ACT00858.1 - 6e-05 23.1 0.0 0.0002 21.4 0.0 1.9 1 1 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 ACT00858.1 - 0.00013 22.0 0.0 0.00032 20.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 ACT00858.1 - 0.0008 19.0 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ACT00858.1 - 0.02 14.3 0.0 0.052 13.0 0.0 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 ACT00858.1 - 0.069 13.2 0.0 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Adeno_E3_15_3 PF03307.14 ACT00858.1 - 0.14 12.2 0.1 28 4.7 0.0 2.8 3 0 0 3 3 3 0 Adenovirus 15.3kD protein in E3 region Radical_SAM PF04055.21 ACT00859.1 - 2.6e-27 96.2 0.0 4e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily HemN_C PF06969.16 ACT00859.1 - 6e-10 39.0 0.3 1.6e-09 37.7 0.3 1.8 1 1 0 1 1 1 1 HemN C-terminal domain HTH_27 PF13463.6 ACT00859.1 - 0.043 14.3 0.0 0.18 12.3 0.0 2.0 2 0 0 2 2 2 0 Winged helix DNA-binding domain AGO_N PF18236.1 ACT00859.1 - 0.24 11.6 0.3 0.55 10.5 0.1 1.7 2 0 0 2 2 2 0 Argonaute N domain Acetyltransf_1 PF00583.25 ACT00860.1 - 7.8e-12 45.5 0.0 9.7e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT00860.1 - 2.6e-10 40.3 0.0 3.3e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT00860.1 - 1.4e-08 35.0 0.1 2.1e-08 34.4 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACT00860.1 - 0.00077 19.5 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_6 PF13480.7 ACT00860.1 - 0.0086 16.2 0.0 0.021 15.0 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain RNase_Zc3h12a PF11977.8 ACT00860.1 - 0.03 14.1 0.1 0.045 13.5 0.1 1.3 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain TFIIA_gamma_N PF02268.16 ACT00860.1 - 0.038 14.0 0.0 0.13 12.3 0.0 1.8 2 0 0 2 2 2 0 Transcription initiation factor IIA, gamma subunit, helical domain Acetyltransf_9 PF13527.7 ACT00860.1 - 0.098 12.7 0.0 0.58 10.2 0.0 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACT00860.1 - 0.12 12.5 0.1 0.19 11.8 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain HrcA PF01628.21 ACT00861.1 - 1e-66 225.0 0.7 1e-66 225.0 0.7 1.3 2 0 0 2 2 2 1 HrcA protein C terminal domain HrcA_DNA-bdg PF03444.15 ACT00861.1 - 2.1e-06 27.3 0.0 5e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding DUF4268 PF14088.6 ACT00861.1 - 0.0045 16.9 0.1 0.0079 16.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4268) LexA_DNA_bind PF01726.16 ACT00861.1 - 0.029 14.2 0.0 0.1 12.4 0.0 1.9 2 0 0 2 2 2 0 LexA DNA binding domain GrpE PF01025.19 ACT00862.1 - 9.2e-57 191.3 8.2 1.1e-56 191.1 8.2 1.0 1 0 0 1 1 1 1 GrpE Atg14 PF10186.9 ACT00862.1 - 0.01 15.0 1.7 0.011 14.9 1.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Terminase_2 PF03592.16 ACT00862.1 - 0.012 16.1 3.1 0.017 15.5 3.1 1.2 1 0 0 1 1 1 0 Terminase small subunit DMSP_lyase PF16867.5 ACT00862.1 - 0.068 12.8 0.4 0.2 11.3 0.1 1.8 1 1 1 2 2 2 0 Dimethlysulfonioproprionate lyase Peptidase_M2 PF01401.18 ACT00862.1 - 0.071 11.7 2.6 0.083 11.5 2.6 1.0 1 0 0 1 1 1 0 Angiotensin-converting enzyme DUF3090 PF11290.8 ACT00862.1 - 0.085 12.7 0.2 0.085 12.7 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3090) DUF1764 PF08576.10 ACT00862.1 - 2.2 9.2 5.5 5.1 8.0 5.5 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) PDCD2_C PF04194.13 ACT00862.1 - 2.4 8.2 7.0 3.4 7.7 6.4 1.5 1 1 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain HSP70 PF00012.20 ACT00863.1 - 3.6e-246 818.1 20.9 2e-215 716.5 14.4 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ACT00863.1 - 2e-22 79.5 5.7 3.9e-22 78.5 5.7 1.4 1 0 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 ACT00863.1 - 0.09 12.5 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 ACT00863.1 - 0.32 11.5 8.6 0.92 10.0 3.2 3.7 2 1 0 2 2 2 0 Cell division protein FtsA DnaJ_C PF01556.18 ACT00864.1 - 2.1e-45 154.4 0.1 2.1e-45 154.4 0.1 1.5 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ PF00226.31 ACT00864.1 - 1.3e-25 89.3 1.5 2.6e-25 88.3 1.5 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ACT00864.1 - 4.2e-14 52.7 18.9 8.2e-14 51.7 18.9 1.5 1 0 0 1 1 1 1 DnaJ central domain Cytochrome_C7 PF14522.6 ACT00864.1 - 1.8 8.6 12.2 13 5.9 12.2 2.3 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c RseC_MucC PF04246.12 ACT00864.1 - 2 8.4 6.7 3.2 7.7 0.8 2.5 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Cytochrom_c3_2 PF14537.6 ACT00864.1 - 2.5 8.6 9.5 10 6.6 9.3 2.1 1 1 1 2 2 2 0 Cytochrome c3 Cytochrom_C PF00034.21 ACT00864.1 - 2.6 9.3 6.3 47 5.2 0.0 3.1 3 0 0 3 3 3 0 Cytochrome c Anti-TRAP PF15777.5 ACT00864.1 - 3.4 7.7 19.4 10 6.2 6.0 3.5 1 1 3 4 4 4 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-CHY PF05495.12 ACT00864.1 - 4.7 7.8 6.7 1.3 9.6 3.5 1.7 1 1 0 1 1 1 0 CHY zinc finger Cytochrome_CBB3 PF13442.6 ACT00864.1 - 6.8 7.1 13.4 2.7 8.4 1.0 3.1 1 1 2 3 3 3 0 Cytochrome C oxidase, cbb3-type, subunit III YfhD PF14151.6 ACT00865.1 - 6.1e-16 58.3 6.2 6.7e-16 58.2 6.2 1.0 1 0 0 1 1 1 1 YfhD-like protein PrmA PF06325.13 ACT00867.1 - 5.4e-94 314.9 0.1 6.8e-94 314.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 ACT00867.1 - 1.1e-08 35.1 0.0 1.9e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 ACT00867.1 - 1.1e-08 34.8 0.1 1.7e-08 34.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 ACT00867.1 - 2.1e-07 31.0 0.2 4.5e-07 29.9 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT00867.1 - 3.8e-07 30.0 0.0 8.4e-07 28.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT00867.1 - 1.8e-05 25.3 0.1 5.7e-05 23.7 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ACT00867.1 - 0.00018 21.2 0.0 0.00036 20.2 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 ACT00867.1 - 0.00066 20.3 0.0 0.002 18.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ACT00867.1 - 0.0034 17.2 0.1 0.0055 16.5 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 ACT00867.1 - 0.0049 16.7 0.0 0.0099 15.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain TRM PF02005.16 ACT00867.1 - 0.047 12.9 0.0 0.067 12.3 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_16 PF10294.9 ACT00867.1 - 0.057 13.2 0.3 0.11 12.3 0.3 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Peptidase_M50 PF02163.22 ACT00868.1 - 1.2e-11 44.4 11.2 6.3e-09 35.5 1.2 2.9 1 1 1 2 2 2 2 Peptidase family M50 Methyltrans_RNA PF04452.14 ACT00869.1 - 8.6e-64 215.0 0.1 9.9e-64 214.8 0.1 1.0 1 0 0 1 1 1 1 RNA methyltransferase UPF0004 PF00919.20 ACT00870.1 - 4.9e-27 93.9 0.0 1.1e-26 92.8 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 ACT00870.1 - 7.2e-26 91.5 0.1 1.7e-25 90.3 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily B12-binding PF02310.19 ACT00870.1 - 0.015 15.3 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 B12 binding domain TRAM PF01938.20 ACT00870.1 - 0.06 13.3 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 TRAM domain Mg_chelatase PF01078.21 ACT00870.1 - 0.09 12.1 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI JAKMIP_CC3 PF16034.5 ACT00870.1 - 0.16 11.9 0.0 0.39 10.6 0.0 1.6 2 0 0 2 2 2 0 JAKMIP CC3 domain NUDIX PF00293.28 ACT00871.1 - 5.2e-20 71.8 0.1 5.8e-20 71.7 0.1 1.0 1 0 0 1 1 1 1 NUDIX domain Na_Pi_cotrans PF02690.15 ACT00872.1 - 1.2e-46 158.3 26.4 4.9e-30 104.4 10.7 2.3 1 1 1 2 2 2 2 Na+/Pi-cotransporter PUA_3 PF17785.1 ACT00873.1 - 6.9e-24 83.4 0.1 1.4e-23 82.4 0.1 1.6 1 0 0 1 1 1 1 PUA-like domain Methyltrans_SAM PF10672.9 ACT00873.1 - 4.9e-15 55.5 0.0 0.00074 18.8 0.0 3.2 3 0 0 3 3 3 3 S-adenosylmethionine-dependent methyltransferase Methyltransf_25 PF13649.6 ACT00873.1 - 1.7e-08 35.1 0.2 8.7e-08 32.8 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ACT00873.1 - 8.5e-08 32.0 0.0 1.3e-06 28.2 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 ACT00873.1 - 1.2e-07 31.6 0.0 3e-07 30.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ACT00873.1 - 1.1e-05 25.3 0.0 0.00046 20.0 0.0 2.1 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_11 PF08241.12 ACT00873.1 - 5.4e-05 23.8 0.1 0.00018 22.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 ACT00873.1 - 0.00023 20.7 0.0 0.00035 20.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 ACT00873.1 - 0.0027 17.6 0.0 0.0045 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ACT00873.1 - 0.0031 17.1 0.0 0.0076 15.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_24 PF13578.6 ACT00873.1 - 0.0059 17.6 0.0 0.012 16.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Big_6 PF17936.1 ACT00873.1 - 0.011 16.0 0.0 0.033 14.5 0.0 1.8 1 0 0 1 1 1 0 Bacterial Ig domain Methyltransf_12 PF08242.12 ACT00873.1 - 0.013 16.2 0.0 0.038 14.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 ACT00873.1 - 0.028 14.0 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.18 ACT00873.1 - 0.034 13.8 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 TRM PF02005.16 ACT00873.1 - 0.035 13.3 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_20 PF12147.8 ACT00873.1 - 0.042 13.0 0.0 0.95 8.5 0.0 2.5 3 0 0 3 3 3 0 Putative methyltransferase PUA PF01472.20 ACT00873.1 - 0.044 13.7 0.1 0.11 12.5 0.0 1.7 2 0 0 2 2 1 0 PUA domain Ubie_methyltran PF01209.18 ACT00873.1 - 0.058 12.7 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF4310 PF14187.6 ACT00873.1 - 0.21 11.2 0.0 0.32 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4310) PDDEXK_1 PF12705.7 ACT00875.1 - 3.1e-57 194.4 0.0 6.6e-56 190.1 0.0 2.5 3 0 0 3 3 3 1 PD-(D/E)XK nuclease superfamily Exonuc_V_gamma PF04257.14 ACT00875.1 - 6.4e-15 54.4 0.2 2.7e-14 52.4 0.2 1.7 1 1 0 1 1 1 1 Exodeoxyribonuclease V, gamma subunit UvrD_C PF13361.6 ACT00875.1 - 0.037 13.4 0.0 0.087 12.2 0.0 1.6 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain RP-C PF03428.13 ACT00875.1 - 0.52 10.0 3.1 3.1 7.4 0.4 2.9 3 0 0 3 3 3 0 Replication protein C N-terminal domain UvrD-helicase PF00580.21 ACT00876.1 - 1.8e-81 274.1 0.0 2.9e-81 273.4 0.0 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ACT00876.1 - 7.5e-25 88.0 0.0 1.1e-14 54.6 0.0 3.1 2 1 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ACT00876.1 - 1.1e-18 67.9 0.0 5.4e-18 65.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain PDDEXK_1 PF12705.7 ACT00876.1 - 4e-11 43.3 0.1 3.8e-10 40.1 0.0 2.5 2 0 0 2 2 2 1 PD-(D/E)XK nuclease superfamily UvrD_C_2 PF13538.6 ACT00876.1 - 9.5e-09 35.0 0.3 0.0002 21.1 0.0 2.6 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain DEAD PF00270.29 ACT00876.1 - 0.00062 19.6 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Viral_helicase1 PF01443.18 ACT00876.1 - 0.0019 18.0 0.0 4.8 6.8 0.0 3.3 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 ACT00876.1 - 0.014 15.1 0.1 0.041 13.6 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_12 PF13087.6 ACT00876.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain HK97-gp10_like PF04883.12 ACT00876.1 - 0.62 11.1 3.0 18 6.4 0.2 2.9 2 0 0 2 2 2 0 Bacteriophage HK97-gp10, putative tail-component TssO PF17561.2 ACT00877.1 - 0.033 14.3 0.4 0.092 12.8 0.4 1.8 1 1 0 1 1 1 0 Type VI secretion system, TssO Vps53_N PF04100.12 ACT00877.1 - 0.045 12.7 0.2 0.058 12.4 0.2 1.2 1 0 0 1 1 1 0 Vps53-like, N-terminal HIT PF01230.23 ACT00879.1 - 9.6e-27 93.6 0.0 1.1e-26 93.4 0.0 1.0 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ACT00879.1 - 7.5e-25 87.6 0.0 8.6e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CDH PF02611.15 ACT00879.1 - 0.0073 15.9 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 CDP-diacylglycerol pyrophosphatase GalP_UDP_tr_C PF02744.17 ACT00879.1 - 0.15 11.7 0.1 0.28 10.9 0.1 1.4 1 1 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain Ribosomal_S21 PF01165.20 ACT00880.1 - 9.1e-21 73.3 10.9 9.6e-21 73.3 10.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S21 SVIP PF15811.5 ACT00880.1 - 1.1 9.7 7.8 0.74 10.3 2.9 2.0 1 1 1 2 2 2 0 Small VCP/p97-interacting protein YqeY PF09424.10 ACT00881.1 - 4.1e-55 185.8 5.8 4.6e-55 185.6 5.8 1.0 1 0 0 1 1 1 1 Yqey-like protein GatB_Yqey PF02637.18 ACT00881.1 - 0.00038 20.3 3.4 0.00078 19.3 3.4 1.7 1 1 0 1 1 1 1 GatB domain Urocanase PF01175.18 ACT00881.1 - 0.05 13.2 0.0 0.074 12.7 0.0 1.3 1 1 0 1 1 1 0 Urocanase Rossmann-like domain His_kinase PF06580.13 ACT00881.1 - 0.11 12.9 0.1 0.29 11.5 0.1 1.9 1 1 0 1 1 1 0 Histidine kinase FGAR-AT_linker PF18072.1 ACT00881.1 - 0.11 13.0 0.1 0.95 10.1 0.0 2.3 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain NfeD PF01957.18 ACT00882.1 - 1.8e-14 53.8 1.7 9.2e-14 51.6 1.7 2.3 1 0 0 1 1 1 1 NfeD-like C-terminal, partner-binding SDH_sah PF01972.16 ACT00882.1 - 2e-06 27.0 0.0 4.4e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Serine dehydrogenase proteinase CLP_protease PF00574.23 ACT00882.1 - 2.7e-05 24.1 0.1 6.6e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 Clp protease Peptidase_S49 PF01343.18 ACT00882.1 - 0.00038 20.4 2.2 0.002 18.1 0.6 2.3 2 0 0 2 2 2 1 Peptidase family S49 DUF1180 PF06679.12 ACT00882.1 - 0.0013 19.2 0.3 0.0031 17.9 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) Phage_holin_2_1 PF04971.12 ACT00882.1 - 0.66 10.0 4.6 5.8 7.0 1.1 2.6 2 0 0 2 2 2 0 Bacteriophage P21 holin S SUR7 PF06687.12 ACT00882.1 - 2.3 7.8 8.4 2.4 7.7 5.5 2.1 2 0 0 2 2 2 0 SUR7/PalI family YdfA_immunity PF12127.8 ACT00883.1 - 7.2e-165 547.6 18.9 8.5e-165 547.4 18.9 1.0 1 0 0 1 1 1 1 SigmaW regulon antibacterial Seryl_tRNA_N PF02403.22 ACT00883.1 - 0.0013 18.9 1.2 0.0029 17.8 1.2 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Band_7 PF01145.25 ACT00883.1 - 0.045 13.8 4.7 0.15 12.0 4.5 2.0 1 1 0 1 1 1 0 SPFH domain / Band 7 family DUF4834 PF16118.5 ACT00884.1 - 0.19 12.7 0.0 0.57 11.2 0.0 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) YabP PF07873.11 ACT00885.1 - 2.2e-19 69.0 0.2 2.8e-19 68.7 0.2 1.1 1 0 0 1 1 1 1 YabP family CooT PF10133.9 ACT00885.1 - 0.11 12.8 0.1 0.19 12.1 0.1 1.3 1 0 0 1 1 1 0 CO dehydrogenase accessory protein CooT YqfD PF06898.11 ACT00886.1 - 5.3e-119 397.4 5.7 6e-119 397.3 5.7 1.0 1 0 0 1 1 1 1 Putative stage IV sporulation protein YqfD POTRA_1 PF08478.10 ACT00886.1 - 0.043 14.1 0.2 0.17 12.2 0.2 2.1 1 0 0 1 1 1 0 POTRA domain, FtsQ-type PhoH PF02562.16 ACT00887.1 - 5.6e-96 319.9 0.0 8.6e-96 319.3 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein AAA_30 PF13604.6 ACT00887.1 - 2.8e-08 33.7 0.0 5.3e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ACT00887.1 - 1e-06 29.2 0.1 2.7e-06 27.8 0.1 1.7 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ACT00887.1 - 9.2e-05 22.2 0.0 0.00019 21.2 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 ACT00887.1 - 0.00043 20.6 0.4 0.0073 16.6 0.1 2.9 1 1 1 2 2 2 1 AAA domain UvrD-helicase PF00580.21 ACT00887.1 - 0.015 14.8 0.9 0.95 8.9 0.0 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DEAD PF00270.29 ACT00887.1 - 0.017 14.9 0.2 0.31 10.8 0.2 2.3 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_25 PF13481.6 ACT00887.1 - 0.031 13.9 0.1 0.058 13.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ACT00887.1 - 0.035 14.5 0.1 0.44 10.9 0.0 2.4 1 1 1 2 2 2 0 AAA ATPase domain Zot PF05707.12 ACT00887.1 - 0.037 13.7 0.1 7.2 6.2 0.0 2.3 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) Parvo_NS1 PF01057.17 ACT00887.1 - 0.12 11.4 0.1 0.21 10.6 0.1 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 7TM-7TMR_HD PF07698.11 ACT00888.1 - 1.9e-34 119.2 24.7 1.9e-34 119.2 24.7 1.5 2 0 0 2 2 2 1 7TM receptor with intracellular HD hydrolase 7TMR-HDED PF07697.11 ACT00888.1 - 3.4e-32 112.4 12.5 6.3e-32 111.5 12.5 1.5 1 0 0 1 1 1 1 7TM-HD extracellular HD PF01966.22 ACT00888.1 - 4.8e-17 62.3 0.0 1.1e-16 61.2 0.0 1.6 1 0 0 1 1 1 1 HD domain DUF3328 PF11807.8 ACT00888.1 - 0.15 11.8 0.2 0.61 9.8 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3328) DUF1774 PF08611.10 ACT00888.1 - 3.9 7.9 8.8 4 7.8 5.1 2.7 2 1 0 2 2 2 0 Fungal protein of unknown function (DUF1774) UPF0054 PF02130.17 ACT00889.1 - 3.4e-46 156.2 1.2 4.1e-46 155.9 1.2 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 DUF5406 PF17400.2 ACT00889.1 - 0.077 13.4 0.4 0.14 12.6 0.3 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5406) DAGK_prokar PF01219.19 ACT00890.1 - 1.8e-34 117.7 8.3 2e-34 117.5 8.3 1.0 1 0 0 1 1 1 1 Prokaryotic diacylglycerol kinase YiaAB PF05360.14 ACT00890.1 - 7.1 7.0 9.8 4.9 7.5 0.1 2.8 2 1 1 3 3 3 0 yiaA/B two helix domain dCMP_cyt_deam_1 PF00383.23 ACT00891.1 - 1.1e-16 60.6 0.1 1.3e-16 60.3 0.1 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 ACT00891.1 - 6.5e-14 52.3 0.1 1.4e-12 47.9 0.1 2.0 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 ACT00891.1 - 0.00086 19.0 3.5 0.12 11.9 0.8 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases MMR_HSR1 PF01926.23 ACT00892.1 - 8.1e-26 90.3 0.1 1.4e-25 89.6 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase KH_2 PF07650.17 ACT00892.1 - 3.4e-20 71.7 2.8 7.2e-20 70.6 2.4 1.8 2 0 0 2 2 2 1 KH domain GTP_EFTU PF00009.27 ACT00892.1 - 3.7e-15 56.0 0.1 8.6e-13 48.3 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ACT00892.1 - 6.4e-14 51.8 0.1 1.1e-13 51.1 0.1 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ACT00892.1 - 1.5e-09 38.1 0.0 0.00027 21.1 0.0 2.3 1 1 1 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 ACT00892.1 - 6.3e-09 36.0 0.7 0.00015 21.7 0.3 2.3 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 ACT00892.1 - 9.4e-05 21.8 0.0 0.00015 21.1 0.0 1.3 1 0 0 1 1 1 1 AIG1 family Ras PF00071.22 ACT00892.1 - 0.0002 21.0 0.0 0.00033 20.3 0.0 1.4 1 0 0 1 1 1 1 Ras family MMR_HSR1_Xtn PF16897.5 ACT00892.1 - 0.00039 20.4 0.0 0.00091 19.2 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain cobW PF02492.19 ACT00892.1 - 0.0021 17.7 0.2 0.16 11.5 0.0 2.3 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Gtr1_RagA PF04670.12 ACT00892.1 - 0.0023 17.3 0.1 0.0048 16.3 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ACT00892.1 - 0.0038 16.7 0.0 0.0066 15.9 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 ACT00892.1 - 0.0039 16.9 0.2 0.025 14.3 0.2 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 ACT00892.1 - 0.0047 17.1 0.2 0.052 13.8 0.2 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ACT00892.1 - 0.013 15.7 0.0 0.071 13.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ACT00892.1 - 0.017 15.7 0.1 0.048 14.2 0.0 1.9 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 ACT00892.1 - 0.044 14.2 0.0 0.084 13.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase MeaB PF03308.16 ACT00892.1 - 0.051 12.5 0.3 1.6 7.6 0.0 2.7 2 1 1 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RHD3 PF05879.12 ACT00892.1 - 0.073 11.2 0.0 0.1 10.7 0.0 1.2 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) AAA_29 PF13555.6 ACT00892.1 - 0.18 11.5 0.0 0.44 10.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain YqzL PF14006.6 ACT00893.1 - 3.6e-17 62.5 0.1 4.2e-17 62.2 0.1 1.1 1 0 0 1 1 1 1 YqzL-like protein RecO_C PF02565.15 ACT00894.1 - 3.4e-40 137.4 0.2 4.1e-40 137.1 0.2 1.1 1 0 0 1 1 1 1 Recombination protein O C terminal RecO_N PF11967.8 ACT00894.1 - 9.4e-24 83.2 0.1 2.4e-23 81.9 0.1 1.7 2 0 0 2 2 2 1 Recombination protein O N terminal RecO_N_2 PF13114.6 ACT00894.1 - 5.7e-19 67.6 0.1 1.1e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 RecO N terminal tRNA-synt_2e PF02091.15 ACT00895.1 - 4.8e-153 508.2 0.1 5.4e-153 508.1 0.1 1.0 1 0 0 1 1 1 1 Glycyl-tRNA synthetase alpha subunit tRNA_synt_2f PF02092.17 ACT00896.1 - 1.8e-217 723.5 1.0 2.6e-217 723.0 1.0 1.2 1 0 0 1 1 1 1 Glycyl-tRNA synthetase beta subunit DALR_1 PF05746.15 ACT00896.1 - 5.3e-07 29.8 5.5 1.6e-06 28.3 0.4 3.6 3 0 0 3 3 3 1 DALR anticodon binding domain RAC_head PF16717.5 ACT00896.1 - 0.31 12.1 1.8 0.73 10.9 0.2 2.4 2 0 0 2 2 2 0 Ribosome-associated complex head domain Kinase-PPPase PF03618.14 ACT00897.1 - 1.3e-93 313.5 0.0 1.4e-93 313.3 0.0 1.0 1 0 0 1 1 1 1 Kinase/pyrophosphorylase DUF188 PF02639.14 ACT00898.1 - 1.8e-43 147.3 0.1 2.1e-43 147.1 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized BCR, YaiI/YqxD family COG1671 Toprim_N PF08275.11 ACT00899.1 - 5e-40 136.5 0.0 2.4e-39 134.3 0.0 2.1 2 0 0 2 2 2 1 DNA primase catalytic core, N-terminal domain zf-CHC2 PF01807.20 ACT00899.1 - 1.5e-33 114.5 0.0 4.4e-33 113.0 0.0 1.8 2 0 0 2 2 2 1 CHC2 zinc finger Toprim_2 PF13155.6 ACT00899.1 - 5.6e-20 71.6 0.0 1.6e-19 70.1 0.0 1.8 1 0 0 1 1 1 1 Toprim-like Toprim_4 PF13662.6 ACT00899.1 - 1.6e-17 63.8 0.2 9e-17 61.3 0.1 2.3 3 0 0 3 3 3 1 Toprim domain Toprim_3 PF13362.6 ACT00899.1 - 2.2e-08 34.3 0.2 1e-07 32.2 0.0 2.2 2 0 0 2 2 2 1 Toprim domain DnaB_bind PF10410.9 ACT00899.1 - 5.4e-08 32.9 0.2 1.9e-07 31.2 0.2 2.0 1 0 0 1 1 1 1 DnaB-helicase binding domain of primase Toprim PF01751.22 ACT00899.1 - 7.4e-06 26.1 0.1 2.6e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 Toprim domain SANTA PF09133.10 ACT00899.1 - 0.047 14.2 0.0 2.2 8.8 0.0 2.7 2 0 0 2 2 2 0 SANTA (SANT Associated) Sigma70_r3 PF04539.16 ACT00900.1 - 1.3e-32 111.7 4.6 8.6e-32 109.1 2.4 2.7 2 0 0 2 2 2 1 Sigma-70 region 3 Sigma70_r2 PF04542.14 ACT00900.1 - 1.7e-22 79.0 0.2 3.2e-22 78.1 0.2 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 ACT00900.1 - 1.2e-21 76.0 9.8 5.9e-20 70.5 2.4 3.2 3 0 0 3 3 3 2 Sigma-70, region 4 Sigma70_r1_2 PF00140.20 ACT00900.1 - 1.8e-19 69.4 1.5 4.5e-19 68.2 0.6 2.2 2 0 0 2 2 2 1 Sigma-70 factor, region 1.2 Sigma70_r1_1 PF03979.14 ACT00900.1 - 2.4e-17 62.7 8.1 1.1e-16 60.7 5.4 2.6 2 0 0 2 2 2 1 Sigma-70 factor, region 1.1 Exonuc_VII_L PF02601.15 ACT00900.1 - 0.011 15.4 0.6 0.043 13.4 0.0 2.1 2 1 0 2 2 2 0 Exonuclease VII, large subunit HTH_10 PF04967.12 ACT00900.1 - 0.025 14.4 0.3 2.4 8.1 0.1 2.8 2 1 0 2 2 2 0 HTH DNA binding domain DUF2316 PF10078.9 ACT00900.1 - 0.39 11.0 2.6 2.4 8.5 0.1 3.4 3 1 2 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2316) 7TMR-DISM_7TM PF07695.11 ACT00901.1 - 0.0063 16.4 7.4 0.0063 16.4 7.4 2.2 1 1 1 2 2 2 1 7TM diverse intracellular signalling DUF3792 PF12670.7 ACT00901.1 - 2.8 8.1 15.5 5.4 7.2 10.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3792) TrmK PF04816.12 ACT00902.1 - 5.4e-57 192.6 0.0 1.9e-55 187.6 0.0 2.0 1 1 0 1 1 1 1 tRNA (adenine(22)-N(1))-methyltransferase Methyltransf_18 PF12847.7 ACT00902.1 - 9e-50 168.5 0.0 1.5e-49 167.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NIF3 PF01784.18 ACT00903.1 - 2.3e-76 256.7 0.3 3e-76 256.3 0.3 1.1 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Peptidase_S8 PF00082.22 ACT00904.1 - 2.8e-48 164.7 10.6 6.5e-48 163.5 10.6 1.6 1 0 0 1 1 1 1 Subtilase family DUF3791 PF12668.7 ACT00904.1 - 0.084 12.9 0.2 0.26 11.3 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) DUF3907 PF13047.6 ACT00905.1 - 1.8e-64 216.1 2.2 2.1e-64 215.9 2.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3907) DUF1540 PF07561.11 ACT00906.1 - 4e-15 55.8 4.2 5.2e-15 55.5 4.2 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1540) DUF5353 PF17304.2 ACT00907.1 - 2.4 7.9 7.3 0.71 9.7 3.6 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5353) ABC_tran PF00005.27 ACT00908.1 - 1.2e-30 106.8 0.0 1.6e-30 106.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT00908.1 - 7.1e-10 39.2 1.0 9.9e-06 25.6 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT00908.1 - 0.005 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 ACT00908.1 - 0.0063 16.0 0.0 1.4 8.3 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ACT00908.1 - 0.014 15.9 0.0 0.02 15.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 ACT00908.1 - 0.047 11.2 0.1 0.059 10.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_30 PF13604.6 ACT00908.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACT00908.1 - 0.07 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase Arf PF00025.21 ACT00908.1 - 0.084 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA PF00004.29 ACT00908.1 - 0.14 12.6 0.1 2 8.9 0.1 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 ACT00908.1 - 0.16 11.7 0.1 0.99 9.0 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Chlorophyllase2 PF12740.7 ACT00909.1 - 1.2e-08 34.2 0.0 2.6e-08 33.1 0.0 1.5 2 0 0 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 ACT00909.1 - 6.6e-06 25.4 0.0 1.1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase PAF-AH_p_II PF03403.13 ACT00909.1 - 0.027 13.0 0.0 0.82 8.1 0.0 2.6 3 0 0 3 3 3 0 Platelet-activating factor acetylhydrolase, isoform II PHO4 PF01384.20 ACT00909.1 - 0.089 11.8 0.0 0.092 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphate transporter family DUF2070 PF09843.9 ACT00909.1 - 4.6 5.4 11.1 7 4.8 11.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Vut_1 PF02592.15 ACT00910.1 - 6e-51 172.7 8.1 6e-51 172.7 8.1 1.5 2 0 0 2 2 2 1 Putative vitamin uptake transporter UvrD_C PF13361.6 ACT00911.1 - 5.4e-13 49.0 0.2 1.4e-05 24.7 0.0 2.8 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 ACT00911.1 - 4.1e-11 43.0 3.7 6.8e-06 25.8 2.0 2.5 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 ACT00911.1 - 1.1e-09 38.8 0.0 2.1e-08 34.6 0.0 2.6 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 ACT00911.1 - 1.3e-08 34.5 0.0 3.1e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 ACT00911.1 - 0.00016 21.5 0.0 0.49 10.1 0.0 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 ACT00911.1 - 0.0012 18.6 0.0 0.066 12.9 0.0 3.1 4 0 0 4 4 4 1 AAA domain PhoH PF02562.16 ACT00911.1 - 0.0042 16.6 0.0 0.4 10.1 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 ACT00911.1 - 0.015 15.6 0.1 4.6 7.5 0.0 3.5 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 ACT00911.1 - 0.016 15.1 0.0 0.039 13.9 0.0 1.7 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.9 ACT00911.1 - 0.019 14.2 0.2 0.062 12.5 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 ACT00911.1 - 0.034 13.9 0.0 0.12 12.1 0.0 1.9 2 1 0 2 2 2 0 DEAD/DEAH box helicase ResIII PF04851.15 ACT00911.1 - 0.11 12.5 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_16 PF13191.6 ACT00911.1 - 0.11 12.9 0.0 0.48 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain HTH_26 PF13443.6 ACT00912.1 - 4.4e-09 36.6 0.1 1.7e-08 34.8 0.0 1.8 2 0 0 2 2 2 1 Cro/C1-type HTH DNA-binding domain HTH_3 PF01381.22 ACT00912.1 - 1.5e-06 28.1 1.1 2.3e-06 27.5 0.1 1.9 3 0 0 3 3 3 1 Helix-turn-helix PAS PF00989.25 ACT00912.1 - 0.00038 20.4 0.0 0.00065 19.7 0.0 1.5 1 1 0 1 1 1 1 PAS fold PAS_8 PF13188.7 ACT00912.1 - 0.00048 20.1 0.0 0.001 19.0 0.0 1.6 1 0 0 1 1 1 1 PAS domain HTH_31 PF13560.6 ACT00912.1 - 0.004 17.5 0.0 0.013 15.8 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain PAS_9 PF13426.7 ACT00912.1 - 0.0062 16.8 0.0 0.013 15.8 0.0 1.6 1 1 0 1 1 1 1 PAS domain HTH_35 PF13693.6 ACT00912.1 - 0.012 15.6 0.1 0.036 14.1 0.1 1.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding PAS_3 PF08447.12 ACT00912.1 - 0.013 15.8 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 PAS fold HTH_11 PF08279.12 ACT00912.1 - 0.014 15.3 0.1 0.41 10.6 0.1 2.4 2 0 0 2 2 2 0 HTH domain HTH_37 PF13744.6 ACT00912.1 - 0.035 14.0 0.3 0.1 12.6 0.2 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain CBM_48 PF02922.18 ACT00914.1 - 7.6e-21 74.3 0.0 2.1e-20 72.8 0.0 1.8 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.18 ACT00914.1 - 4.5e-19 68.7 0.1 9.5e-19 67.7 0.1 1.6 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 ACT00914.1 - 1.1e-14 54.8 0.7 4.6e-10 39.6 0.1 2.4 1 1 0 2 2 2 2 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 ACT00914.1 - 0.046 11.9 0.0 0.08 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 70 AMPK1_CBM PF16561.5 ACT00914.1 - 0.22 11.8 1.3 10 6.5 0.1 2.8 2 0 0 2 2 2 0 Glycogen recognition site of AMP-activated protein kinase NTP_transferase PF00483.23 ACT00915.1 - 2.1e-67 227.3 0.0 2.7e-67 226.9 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACT00915.1 - 1.5e-07 31.9 0.0 3.2e-07 30.8 0.0 1.4 1 1 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 ACT00915.1 - 9.3e-05 22.0 8.9 0.0021 17.7 0.2 2.7 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 ACT00915.1 - 0.12 11.3 0.2 1.1 8.2 0.2 2.0 2 0 0 2 2 2 0 L-fucokinase NTP_transferase PF00483.23 ACT00916.1 - 2.2e-10 40.5 0.0 3.2e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Fucokinase PF07959.12 ACT00916.1 - 0.00019 20.5 0.0 0.00032 19.8 0.0 1.3 1 0 0 1 1 1 1 L-fucokinase Glyco_transf_5 PF08323.11 ACT00917.1 - 4.5e-80 268.9 0.0 7.1e-80 268.2 0.0 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 ACT00917.1 - 2.2e-14 53.4 0.0 3.9e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT00917.1 - 2.1e-10 41.2 0.0 3.8e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACT00917.1 - 4.3e-09 36.6 0.0 4e-08 33.4 0.0 2.6 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACT00917.1 - 4.4e-09 37.0 0.0 5.2e-08 33.5 0.0 2.5 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_hydro_15 PF00723.21 ACT00918.1 - 2.4e-16 59.5 0.2 8.6e-13 47.9 0.5 2.6 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 Trehalase PF01204.18 ACT00918.1 - 0.0049 15.7 0.0 0.0084 15.0 0.0 1.3 1 0 0 1 1 1 1 Trehalase Glyco_hydro_36 PF17167.4 ACT00918.1 - 0.0084 14.8 0.0 0.015 14.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain GerPE PF10970.8 ACT00919.1 - 6.9e-21 74.7 0.1 8.7e-21 74.4 0.1 1.1 1 0 0 1 1 1 1 Spore germination protein GerPE gerPA PF10676.9 ACT00919.1 - 0.00076 19.7 0.6 1.2 9.4 0.1 2.2 2 0 0 2 2 2 2 Spore germination protein gerPA/gerPF GerPE PF10970.8 ACT00920.1 - 0.0057 16.8 0.0 0.0065 16.6 0.0 1.1 1 0 0 1 1 1 1 Spore germination protein GerPE GerPC PF10737.9 ACT00921.1 - 6.1e-59 199.0 0.1 7.2e-59 198.8 0.1 1.0 1 0 0 1 1 1 1 Spore germination protein GerPC NPV_P10 PF05531.12 ACT00921.1 - 0.093 13.2 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 ACT00921.1 - 0.33 11.6 8.3 0.23 12.1 4.9 2.5 2 1 0 2 2 2 0 SlyX Csm1_N PF18504.1 ACT00921.1 - 0.52 10.7 6.3 0.15 12.4 3.0 1.8 2 0 0 2 2 2 0 Csm1 N-terminal domain Spc24 PF08286.11 ACT00921.1 - 0.61 10.4 4.5 0.16 12.2 0.8 1.9 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 FlxA PF14282.6 ACT00921.1 - 2 8.4 10.9 0.12 12.4 3.5 2.3 2 0 0 2 2 2 0 FlxA-like protein GerPB PF10803.8 ACT00922.1 - 2.2e-31 107.7 1.9 2.5e-31 107.5 1.9 1.0 1 0 0 1 1 1 1 Spore germination GerPB GerPE PF10970.8 ACT00922.1 - 0.00067 19.8 1.1 0.001 19.3 1.2 1.3 1 1 0 1 1 1 1 Spore germination protein GerPE gerPA PF10676.9 ACT00922.1 - 0.0043 17.3 0.2 0.0058 16.9 0.2 1.2 1 0 0 1 1 1 1 Spore germination protein gerPA/gerPF gerPA PF10676.9 ACT00923.1 - 2.4e-27 95.0 7.0 2.7e-27 94.8 7.0 1.0 1 0 0 1 1 1 1 Spore germination protein gerPA/gerPF GerPE PF10970.8 ACT00923.1 - 0.0042 17.3 0.3 0.0054 16.9 0.3 1.2 1 0 0 1 1 1 1 Spore germination protein GerPE Succ_CoA_lig PF13607.6 ACT00923.1 - 0.023 14.5 1.1 0.11 12.3 0.3 1.9 1 1 1 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain HSP20 PF00011.21 ACT00924.1 - 0.075 13.2 0.1 9.1 6.5 0.0 2.4 1 1 1 2 2 2 0 Hsp20/alpha crystallin family DUF3784 PF12650.7 ACT00925.1 - 0.038 14.2 6.7 0.047 13.9 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) Phage_holin_3_6 PF07332.11 ACT00925.1 - 0.43 10.6 6.3 0.48 10.5 6.3 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III SUR7 PF06687.12 ACT00925.1 - 1.4 8.5 7.6 1.5 8.4 7.6 1.0 1 0 0 1 1 1 0 SUR7/PalI family DUF485 PF04341.12 ACT00926.1 - 0.063 13.2 3.1 3.6 7.6 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Pox_EPC_I2-L1 PF12575.8 ACT00926.1 - 0.07 13.4 4.5 0.83 9.9 0.0 2.0 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 DUF4190 PF13828.6 ACT00926.1 - 0.073 12.8 2.8 0.11 12.2 1.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4190) DUF4131 PF13567.6 ACT00926.1 - 0.24 11.0 2.3 0.25 11.0 2.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2207 PF09972.9 ACT00926.1 - 1.6 7.4 3.0 1.6 7.4 3.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FUR PF01475.19 ACT00927.1 - 9.9e-26 90.2 0.0 1.2e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 Ferric uptake regulator family Trm112p PF03966.16 ACT00927.1 - 0.15 12.7 0.4 0.25 11.9 0.3 1.5 1 1 0 1 1 1 0 Trm112p-like protein YidD PF01809.18 ACT00928.1 - 3e-31 107.1 0.2 3.6e-31 106.9 0.2 1.1 1 0 0 1 1 1 1 Putative membrane protein insertion efficiency factor tRNA-synt_1g PF09334.11 ACT00929.1 - 9.5e-121 403.2 0.0 4.4e-69 233.1 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ACT00929.1 - 1.8e-33 115.7 0.3 3.3e-15 55.4 0.0 4.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA_bind PF01588.20 ACT00929.1 - 1.4e-28 98.9 0.0 2.5e-28 98.0 0.0 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain tRNA-synt_1e PF01406.19 ACT00929.1 - 4.9e-13 49.1 0.0 9.7e-08 31.7 0.1 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 ACT00929.1 - 2.9e-10 40.3 0.0 5.7e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1f PF01921.18 ACT00929.1 - 0.0018 17.3 0.0 0.013 14.5 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (K) ARL2_Bind_BART PF11527.8 ACT00929.1 - 0.088 12.9 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART ZnuA PF01297.17 ACT00930.1 - 1.7e-80 270.2 0.0 1.9e-80 270.0 0.0 1.0 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic DUF4295 PF14128.6 ACT00930.1 - 0.023 14.5 0.0 0.058 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4295) ABC_tran PF00005.27 ACT00931.1 - 9.5e-34 116.8 0.0 2.1e-33 115.8 0.0 1.5 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ACT00931.1 - 5.8e-11 42.8 3.5 5.2e-05 23.2 0.2 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT00931.1 - 2.2e-05 24.0 0.3 0.034 13.6 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT00931.1 - 0.00015 22.1 0.1 0.00068 19.9 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 ACT00931.1 - 0.00088 19.7 0.7 0.015 15.7 0.7 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 ACT00931.1 - 0.0021 17.9 0.0 0.0027 17.5 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT00931.1 - 0.0024 17.6 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACT00931.1 - 0.0047 17.4 0.1 0.0047 17.4 0.1 1.8 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ACT00931.1 - 0.011 15.0 0.9 0.047 12.9 0.1 2.4 2 1 0 2 2 2 0 NB-ARC domain RsgA_GTPase PF03193.16 ACT00931.1 - 0.014 15.3 0.0 0.035 14.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase MobB PF03205.14 ACT00931.1 - 0.018 14.9 0.4 0.032 14.1 0.0 1.7 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B T2SSE PF00437.20 ACT00931.1 - 0.023 13.8 0.0 0.044 12.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 ACT00931.1 - 0.027 14.4 0.2 0.13 12.2 0.1 2.0 2 0 0 2 2 2 0 NACHT domain AAA_27 PF13514.6 ACT00931.1 - 0.029 14.0 1.4 0.047 13.3 0.0 2.0 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 ACT00931.1 - 0.035 14.3 0.0 1.2 9.4 0.0 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 ACT00931.1 - 0.036 13.8 0.1 0.19 11.4 0.0 2.2 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 ACT00931.1 - 0.051 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 ACT00931.1 - 0.06 13.7 0.5 0.48 10.7 0.0 2.4 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 ACT00931.1 - 0.07 12.4 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin cobW PF02492.19 ACT00931.1 - 0.099 12.2 0.2 0.2 11.2 0.2 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ACT00931.1 - 0.12 12.4 0.1 0.82 9.8 0.0 2.2 2 1 0 2 2 2 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 ACT00931.1 - 0.13 12.3 1.5 16 5.5 0.1 2.7 2 1 1 3 3 3 0 Dynamin family AAA_14 PF13173.6 ACT00931.1 - 0.15 12.1 0.4 17 5.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ACT00931.1 - 0.15 12.4 0.0 0.28 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC-3 PF00950.17 ACT00932.1 - 8.1e-63 212.3 37.9 9.3e-63 212.1 37.9 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 ACT00932.1 - 5.7e-06 25.5 36.1 5.7e-06 25.5 36.1 1.5 1 1 1 2 2 2 1 FecCD transport family MotA_ExbB PF01618.16 ACT00932.1 - 0.012 15.4 1.9 0.012 15.4 1.9 2.1 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family DUF2407_C PF13373.6 ACT00932.1 - 0.89 9.7 4.5 0.75 10.0 2.3 2.0 1 1 1 2 2 2 0 DUF2407 C-terminal domain DsbD PF02683.15 ACT00933.1 - 6e-59 199.5 11.5 6.9e-59 199.3 11.5 1.0 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DsbD_2 PF13386.6 ACT00933.1 - 6.7e-06 26.2 21.0 2e-05 24.6 20.6 1.8 1 1 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region MerC PF03203.14 ACT00933.1 - 1 9.9 9.4 2.6 8.5 5.1 2.4 2 0 0 2 2 2 0 MerC mercury resistance protein RseC_MucC PF04246.12 ACT00933.1 - 2.8 7.9 10.8 0.87 9.5 3.4 2.4 2 1 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Fe_dep_repress PF01325.19 ACT00934.1 - 1.6e-24 85.9 0.3 2.4e-24 85.3 0.3 1.3 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain Fe_dep_repr_C PF02742.15 ACT00934.1 - 4.3e-19 68.4 0.5 2.5e-18 65.9 0.1 2.1 2 1 0 2 2 2 1 Iron dependent repressor, metal binding and dimerisation domain MarR PF01047.22 ACT00934.1 - 4e-05 23.5 0.0 8.5e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT00934.1 - 8.6e-05 22.3 0.0 0.00016 21.5 0.0 1.5 1 1 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT00934.1 - 0.00041 19.8 0.0 0.00058 19.4 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_38 PF13936.6 ACT00934.1 - 0.0063 16.3 0.1 0.23 11.3 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain RuvB_C PF05491.13 ACT00934.1 - 0.0064 16.3 0.1 5.2 7.0 0.0 2.9 3 0 0 3 3 3 2 RuvB C-terminal winged helix domain HTH_11 PF08279.12 ACT00934.1 - 0.0085 16.0 0.1 0.026 14.4 0.0 1.8 2 0 0 2 2 2 1 HTH domain TrmB PF01978.19 ACT00934.1 - 0.0098 15.8 0.2 0.024 14.5 0.1 1.8 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 ACT00934.1 - 0.024 14.4 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain Rrf2 PF02082.20 ACT00934.1 - 0.026 14.9 0.1 0.13 12.6 0.1 2.0 1 1 0 1 1 1 0 Transcriptional regulator HTH_Crp_2 PF13545.6 ACT00934.1 - 0.06 13.3 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_DeoR PF08220.12 ACT00934.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain UDG PF03167.19 ACT00935.1 - 1.8e-25 89.7 0.1 2.2e-25 89.5 0.1 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Patatin PF01734.22 ACT00938.1 - 2.8e-24 86.4 0.0 4.4e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase DUF1385 PF07136.11 ACT00940.1 - 2.1e-76 256.2 0.4 2.6e-76 255.9 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1385) Oxidored_q4 PF00507.19 ACT00940.1 - 0.015 15.4 1.5 0.024 14.8 0.8 1.6 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 UL45 PF05473.12 ACT00940.1 - 0.11 12.1 0.0 0.75 9.4 0.0 1.9 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like Babuvirus_MP PF07234.11 ACT00940.1 - 0.38 10.9 2.3 0.36 11.0 0.4 1.9 2 1 0 2 2 2 0 Movement and RNA silencing protein YqhR PF11085.8 ACT00941.1 - 1.1e-29 103.5 7.2 1.3e-29 103.2 7.2 1.0 1 0 0 1 1 1 1 Conserved membrane protein YqhR DUF1440 PF07274.12 ACT00941.1 - 7.6e-06 26.3 2.9 7.6e-06 26.3 2.9 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1440) DUF2975 PF11188.8 ACT00941.1 - 0.34 10.8 3.3 8.6 6.3 1.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) DHquinase_II PF01220.19 ACT00942.1 - 1.7e-62 209.1 0.0 1.9e-62 209.0 0.0 1.0 1 0 0 1 1 1 1 Dehydroquinase class II Peptidase_M24 PF00557.24 ACT00943.1 - 5.5e-70 235.3 0.3 7.4e-70 234.9 0.3 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 ACT00943.1 - 6.9e-28 97.9 0.0 1.1e-27 97.2 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain EFP_N PF08207.12 ACT00944.1 - 2.6e-27 94.6 0.4 6.6e-27 93.3 0.4 1.7 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Elong-fact-P_C PF09285.11 ACT00944.1 - 8.4e-26 89.5 0.9 2e-25 88.3 0.4 2.0 2 0 0 2 2 2 1 Elongation factor P, C-terminal EFP PF01132.20 ACT00944.1 - 1.6e-22 79.3 2.7 1.6e-22 79.3 2.7 1.7 2 0 0 2 2 2 1 Elongation factor P (EF-P) OB domain AA_kinase PF00696.28 ACT00945.1 - 1.9e-55 188.1 2.0 1.9e-55 188.1 2.0 1.6 2 0 0 2 2 2 1 Amino acid kinase family ACT_7 PF13840.6 ACT00945.1 - 4.7e-15 55.1 3.7 2.4e-11 43.3 0.9 2.9 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 ACT00945.1 - 3.1e-11 42.8 3.3 8.6e-07 28.6 0.6 2.7 2 0 0 2 2 2 2 ACT domain ACT_4 PF13291.6 ACT00945.1 - 0.00096 19.7 0.7 0.15 12.7 0.1 2.6 2 0 0 2 2 2 1 ACT domain DUF441 PF04284.13 ACT00946.1 - 5.4e-48 162.6 13.6 6.1e-48 162.4 13.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF441) Sec61_beta PF03911.16 ACT00946.1 - 0.059 13.4 0.5 0.059 13.4 0.5 2.7 3 1 0 3 3 3 0 Sec61beta family DUF3487 PF11990.8 ACT00946.1 - 0.12 12.3 5.6 0.28 11.1 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) 2-ph_phosp PF04029.14 ACT00947.1 - 1.8e-72 243.2 0.5 2e-72 243.0 0.5 1.0 1 0 0 1 1 1 1 2-phosphosulpholactate phosphatase ComA PF02679.15 ACT00948.1 - 1.7e-75 253.6 0.0 2e-75 253.4 0.0 1.0 1 0 0 1 1 1 1 (2R)-phospho-3-sulfolactate synthase (ComA) DUF2619 PF10942.8 ACT00949.1 - 6.6e-31 106.2 3.9 8.9e-31 105.8 3.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2619) Chloroplast_duf PF14476.6 ACT00949.1 - 0.14 11.1 4.1 0.18 10.8 0.6 1.9 1 1 1 2 2 2 0 Petal formation-expressed TniB PF05621.11 ACT00950.1 - 0.0037 16.7 0.0 0.5 9.8 0.0 2.2 2 0 0 2 2 2 2 Bacterial TniB protein NTPase_1 PF03266.15 ACT00950.1 - 0.085 12.8 0.1 1 9.3 0.1 2.3 1 1 0 1 1 1 0 NTPase AAA_16 PF13191.6 ACT00950.1 - 0.12 12.8 0.1 0.33 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain Spore_III_AB PF09548.10 ACT00951.1 - 9.7e-54 182.0 0.2 1.1e-53 181.9 0.2 1.0 1 0 0 1 1 1 1 Stage III sporulation protein AB (spore_III_AB) T2SSF PF00482.23 ACT00951.1 - 0.00089 19.2 4.2 0.023 14.7 0.1 3.0 2 1 1 3 3 3 2 Type II secretion system (T2SS), protein F LapA_dom PF06305.11 ACT00951.1 - 5 7.0 8.9 0.3 10.9 0.8 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain SpoIIIAC PF06686.11 ACT00952.1 - 7.5e-17 61.3 4.8 8.5e-17 61.1 4.8 1.0 1 0 0 1 1 1 1 Stage III sporulation protein AC/AD protein family MRAP PF15183.6 ACT00952.1 - 0.22 11.5 3.8 0.25 11.3 3.3 1.3 1 1 0 1 1 1 0 Melanocortin-2 receptor accessory protein family SpoIIIAC PF06686.11 ACT00953.1 - 2.5e-30 104.4 24.3 1.8e-19 69.7 7.1 2.0 2 0 0 2 2 2 2 Stage III sporulation protein AC/AD protein family Spore_III_AE PF09546.10 ACT00954.1 - 3.4e-108 361.7 43.8 5.1e-108 361.1 43.8 1.2 1 0 0 1 1 1 1 Stage III sporulation protein AE (spore_III_AE) F-box_5 PF18511.1 ACT00954.1 - 0.16 11.5 0.0 0.38 10.4 0.0 1.6 1 0 0 1 1 1 0 F-box Spore_III_AF PF09581.10 ACT00955.1 - 3.1e-39 135.0 4.6 3.7e-39 134.7 4.6 1.0 1 0 0 1 1 1 1 Stage III sporulation protein AF (Spore_III_AF) DUF3069 PF11269.8 ACT00955.1 - 0.0088 16.3 1.1 0.018 15.3 1.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3069) BAT PF15915.5 ACT00956.1 - 0.033 14.1 0.5 0.045 13.6 0.5 1.3 1 0 0 1 1 1 0 GAF and HTH_10 associated domain SpoIIIAH PF12685.7 ACT00957.1 - 1.5e-39 136.1 16.4 1.6e-39 135.9 16.4 1.0 1 0 0 1 1 1 1 SpoIIIAH-like protein Lipoprotein_15 PF03640.15 ACT00957.1 - 0.09 12.3 0.1 0.21 11.2 0.1 1.6 1 0 0 1 1 1 0 Secreted repeat of unknown function Elongin_A PF06881.11 ACT00957.1 - 0.21 12.1 3.6 1.9 9.0 0.4 2.3 1 1 1 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A RPA_C PF08784.11 ACT00957.1 - 1.1 9.9 10.7 0.64 10.7 1.8 2.2 1 1 1 2 2 2 0 Replication protein A C terminal Biotin_lipoyl PF00364.22 ACT00958.1 - 3.4e-23 81.3 0.1 5.2e-23 80.7 0.1 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 ACT00958.1 - 2.7e-06 27.1 0.2 0.0026 17.5 0.0 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like DUF2275 PF10039.9 ACT00958.1 - 0.013 15.6 0.2 0.026 14.6 0.2 1.6 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2275) GCV_H PF01597.19 ACT00958.1 - 0.016 15.1 0.2 0.035 14.0 0.2 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein HlyD_3 PF13437.6 ACT00958.1 - 0.029 15.1 0.0 0.09 13.5 0.0 1.9 1 0 0 1 1 1 0 HlyD family secretion protein DUF4930 PF16284.5 ACT00958.1 - 0.06 13.3 0.0 0.12 12.3 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4930) CPSase_L_D2 PF02786.17 ACT00959.1 - 2.4e-79 265.8 0.3 3.5e-79 265.2 0.3 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ACT00959.1 - 9.1e-48 161.4 2.1 2.4e-47 160.0 0.0 2.8 4 0 0 4 4 3 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ACT00959.1 - 2.7e-44 149.7 0.0 6.6e-44 148.4 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 ACT00959.1 - 7.6e-08 32.1 0.0 2.2e-07 30.6 0.0 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ACT00959.1 - 1.2e-06 28.2 0.1 2.7e-06 27.1 0.0 1.5 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 ACT00959.1 - 2.3e-06 27.5 0.3 4.6e-06 26.5 0.3 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 ACT00959.1 - 2.5e-05 24.0 0.1 0.00021 21.0 0.1 2.1 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 ACT00959.1 - 0.00052 20.1 0.0 0.0009 19.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 ACT00959.1 - 0.032 13.5 0.0 0.084 12.1 0.0 1.6 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp ATP-grasp_5 PF13549.6 ACT00959.1 - 0.033 13.7 0.1 0.06 12.8 0.1 1.4 1 0 0 1 1 1 0 ATP-grasp domain Oxidored_nitro PF00148.19 ACT00959.1 - 0.043 12.5 0.1 0.41 9.3 0.0 2.0 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase Asp23 PF03780.13 ACT00960.1 - 2.2e-38 131.0 6.8 2.5e-38 130.8 6.8 1.0 1 0 0 1 1 1 1 Asp23 family, cell envelope-related function Asp23 PF03780.13 ACT00961.1 - 5.1e-08 33.3 3.2 1.1e-06 29.0 1.1 2.1 1 1 1 2 2 2 2 Asp23 family, cell envelope-related function Tmemb_18A PF09771.9 ACT00961.1 - 0.0083 16.5 0.4 0.012 16.0 0.4 1.3 1 0 0 1 1 1 1 Transmembrane protein 188 Tetraspanin PF00335.20 ACT00961.1 - 0.0097 15.6 3.9 0.014 15.1 3.6 1.4 2 0 0 2 2 2 1 Tetraspanin family DUF2627 PF11118.8 ACT00961.1 - 0.018 15.6 2.6 0.034 14.7 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) Anti-adapt_IraP PF10796.9 ACT00961.1 - 0.11 13.1 0.3 0.18 12.4 0.3 1.4 1 0 0 1 1 1 0 Sigma-S stabilisation anti-adaptor protein CRPA PF05745.11 ACT00961.1 - 3.2 7.7 7.9 0.36 10.8 1.2 2.2 1 1 1 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) DUF2273 PF10031.9 ACT00962.1 - 7.1e-15 54.7 7.9 8.8e-15 54.4 7.9 1.1 1 0 0 1 1 1 1 Small integral membrane protein (DUF2273) DUF3789 PF12664.7 ACT00962.1 - 5.4 6.8 5.7 0.5 10.1 0.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3789) NusB PF01029.18 ACT00963.1 - 2.6e-40 137.8 0.8 2.9e-40 137.6 0.8 1.0 1 0 0 1 1 1 1 NusB family THF_DHG_CYH_C PF02882.19 ACT00964.1 - 2.3e-71 238.3 2.1 3.5e-71 237.7 2.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 ACT00964.1 - 1.9e-41 140.9 1.1 1.9e-41 140.9 1.1 1.5 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain adh_short PF00106.25 ACT00964.1 - 0.0069 15.9 0.3 0.012 15.0 0.3 1.4 1 0 0 1 1 1 1 short chain dehydrogenase AdoHcyase_NAD PF00670.21 ACT00964.1 - 0.026 14.6 1.2 1.5 8.9 1.2 2.4 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Semialdhyde_dh PF01118.24 ACT00964.1 - 0.042 14.3 0.2 0.16 12.4 0.0 2.0 2 1 1 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain Exonuc_VII_L PF02601.15 ACT00965.1 - 3.1e-106 355.4 1.5 3.8e-106 355.1 1.5 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit tRNA_anti_2 PF13742.6 ACT00965.1 - 2.2e-29 101.5 0.1 6.9e-29 99.9 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA_anti-codon PF01336.25 ACT00965.1 - 8.7e-08 32.0 0.0 6.5e-07 29.3 0.0 2.2 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain PGC7_Stella PF15549.6 ACT00965.1 - 0.21 11.6 3.5 0.39 10.7 3.5 1.4 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain Apolipoprotein PF01442.18 ACT00965.1 - 1.5 8.7 21.3 8.2 6.3 21.2 2.3 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Exonuc_VII_S PF02609.16 ACT00966.1 - 1.7e-22 79.2 2.8 2.3e-22 78.8 2.8 1.2 1 0 0 1 1 1 1 Exonuclease VII small subunit polyprenyl_synt PF00348.17 ACT00967.1 - 2e-58 197.5 0.1 2.5e-58 197.2 0.1 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase DXP_synthase_N PF13292.6 ACT00968.1 - 1e-122 408.6 0.2 2.1e-122 407.6 0.1 1.6 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 ACT00968.1 - 1.3e-38 132.5 0.1 2.8e-38 131.4 0.1 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ACT00968.1 - 3.5e-28 98.0 0.0 2e-27 95.5 0.0 2.3 3 0 0 3 3 3 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 ACT00968.1 - 3.7e-08 33.3 0.9 1.2e-06 28.3 0.1 3.0 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PFOR_II PF17147.4 ACT00968.1 - 2.3e-06 27.9 0.0 1.4e-05 25.3 0.0 2.3 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II Transketolase_N PF00456.21 ACT00968.1 - 5.3e-05 22.3 0.2 0.023 13.6 0.2 2.6 2 1 0 2 2 2 2 Transketolase, thiamine diphosphate binding domain E1_dh PF00676.20 ACT00968.1 - 0.0033 16.4 0.0 0.0061 15.5 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component DUF4874 PF16173.5 ACT00968.1 - 0.02 14.6 0.0 0.045 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) FtsJ PF01728.19 ACT00969.1 - 2.3e-16 60.4 0.0 3.1e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase S4 PF01479.25 ACT00969.1 - 8.1e-11 41.5 0.0 1.4e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 ACT00969.1 - 0.075 12.9 0.2 0.18 11.6 0.2 1.6 1 0 0 1 1 1 0 S4 domain Methyltransf_11 PF08241.12 ACT00969.1 - 0.13 12.9 0.0 0.27 11.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 ACT00969.1 - 0.15 12.8 0.0 0.25 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Arg_repressor_C PF02863.18 ACT00971.1 - 2.8e-28 97.6 0.1 5.9e-28 96.5 0.1 1.6 1 0 0 1 1 1 1 Arginine repressor, C-terminal domain Arg_repressor PF01316.21 ACT00971.1 - 7e-26 89.8 0.7 1.3e-25 88.9 0.7 1.4 1 0 0 1 1 1 1 Arginine repressor, DNA binding domain HOIP-UBA PF16678.5 ACT00971.1 - 0.15 12.1 0.3 0.44 10.5 0.1 1.8 3 0 0 3 3 3 0 HOIP UBA domain pair SMC_N PF02463.19 ACT00972.1 - 1.4e-17 63.8 0.0 3.2e-17 62.7 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ACT00972.1 - 3.3e-11 44.1 7.6 2.1e-09 38.2 7.6 2.7 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ACT00972.1 - 1.4e-07 31.6 0.0 0.014 15.2 0.0 2.6 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT00972.1 - 6.6e-06 25.8 0.0 1.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ACT00972.1 - 0.00054 19.8 0.2 0.35 10.5 0.0 2.5 2 1 0 2 2 2 2 AAA ATPase domain ABC_tran PF00005.27 ACT00972.1 - 0.0013 19.3 0.7 0.073 13.6 0.0 3.2 2 1 0 3 3 3 1 ABC transporter AAA_22 PF13401.6 ACT00972.1 - 0.0024 18.1 0.3 0.26 11.5 0.0 3.0 2 2 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ACT00972.1 - 0.019 14.8 0.7 0.078 12.9 0.0 2.3 3 0 0 3 3 3 0 RsgA GTPase AAA_16 PF13191.6 ACT00972.1 - 0.032 14.6 3.8 2 8.8 0.0 2.8 1 1 0 2 2 2 0 AAA ATPase domain CENP-H PF05837.12 ACT00972.1 - 0.04 14.3 9.4 0.19 12.2 1.1 2.8 2 0 0 2 2 2 0 Centromere protein H (CENP-H) MutS_V PF00488.21 ACT00972.1 - 0.094 12.7 2.0 0.26 11.3 0.5 2.2 2 0 0 2 2 2 0 MutS domain V FliS PF02561.14 ACT00972.1 - 0.71 10.2 7.9 0.11 12.8 1.1 2.8 2 0 0 2 2 2 0 Flagellar protein FliS Peptidase_S55 PF05580.12 ACT00973.1 - 1.2e-88 296.5 0.8 1.2e-88 296.5 0.8 1.6 2 0 0 2 2 2 1 SpoIVB peptidase S55 PDZ_6 PF17820.1 ACT00973.1 - 7.8e-11 41.7 0.2 7.2e-09 35.4 0.1 2.6 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 ACT00973.1 - 7.6e-08 32.6 0.2 3.7e-07 30.4 0.2 2.2 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 ACT00973.1 - 0.00031 21.0 3.8 0.00095 19.5 0.7 3.0 3 1 0 3 3 3 1 PDZ domain GRASP55_65 PF04495.14 ACT00973.1 - 0.0048 17.2 0.0 0.02 15.2 0.0 1.9 2 0 0 2 2 2 1 GRASP55/65 PDZ-like domain Tricorn_PDZ PF14685.6 ACT00973.1 - 0.0086 16.0 2.3 0.013 15.4 0.1 2.5 3 0 0 3 3 3 1 Tricorn protease PDZ domain Spo0A_C PF08769.11 ACT00974.1 - 5.9e-46 154.8 1.3 1.9e-45 153.2 0.8 1.9 2 0 0 2 2 2 1 Sporulation initiation factor Spo0A C terminal Response_reg PF00072.24 ACT00974.1 - 1.5e-25 89.5 0.0 2.7e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HTH_Tnp_ISL3 PF13542.6 ACT00974.1 - 0.016 14.6 0.0 5.9 6.4 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 DUF2627 PF11118.8 ACT00975.1 - 1.8e-30 105.3 3.2 2.1e-30 105.1 3.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2627) LPG_synthase_TM PF03706.13 ACT00975.1 - 0.0061 16.1 0.5 0.0063 16.1 0.5 1.0 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region DUF3522 PF12036.8 ACT00975.1 - 0.049 13.9 0.2 0.054 13.8 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3522) FtsX PF02687.21 ACT00975.1 - 0.059 13.8 1.1 0.071 13.6 1.1 1.1 1 0 0 1 1 1 0 FtsX-like permease family DUF2207 PF09972.9 ACT00975.1 - 0.45 9.2 1.2 0.54 9.0 1.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 ACT00975.1 - 0.85 9.7 7.9 33 4.6 7.9 2.0 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Pyr_redox_2 PF07992.14 ACT00976.1 - 2e-64 217.6 1.8 2.5e-64 217.3 1.8 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ACT00976.1 - 6.8e-35 119.7 0.2 5.8e-34 116.7 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ACT00976.1 - 4.4e-21 75.2 4.8 2.4e-18 66.5 0.5 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACT00976.1 - 2.2e-11 43.6 0.5 2.3e-10 40.2 0.5 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ACT00976.1 - 4.7e-08 32.8 0.2 4.7e-08 32.8 0.2 2.8 3 0 0 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 ACT00976.1 - 1.7e-06 27.4 12.3 2.5e-06 26.9 0.8 3.1 2 2 0 3 3 3 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ACT00976.1 - 2.2e-05 23.7 1.5 2.2e-05 23.7 1.5 3.1 4 0 0 4 4 4 1 FAD binding domain AlaDh_PNT_C PF01262.21 ACT00976.1 - 3.2e-05 23.3 4.1 0.054 12.8 0.1 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 ACT00976.1 - 8.4e-05 22.7 7.4 0.008 16.4 0.5 3.1 3 0 0 3 3 2 2 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ACT00976.1 - 0.00013 21.7 9.4 0.15 11.6 0.1 3.4 2 1 1 3 3 3 2 FAD dependent oxidoreductase 3HCDH_N PF02737.18 ACT00976.1 - 0.0002 21.3 2.7 0.0025 17.7 0.1 2.5 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K_oxygenase PF13434.6 ACT00976.1 - 0.00021 20.5 0.0 0.00085 18.6 0.0 1.9 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 ACT00976.1 - 0.00022 20.6 8.4 0.036 13.3 1.6 2.5 2 1 1 3 3 3 2 FAD binding domain HI0933_like PF03486.14 ACT00976.1 - 0.0017 17.1 0.9 0.0017 17.1 0.9 3.2 3 1 1 4 4 4 1 HI0933-like protein Trp_halogenase PF04820.14 ACT00976.1 - 0.0067 15.3 4.0 0.41 9.4 0.1 2.5 2 0 0 2 2 2 2 Tryptophan halogenase Thi4 PF01946.17 ACT00976.1 - 0.031 13.5 1.4 0.45 9.7 0.2 2.5 2 0 0 2 2 2 0 Thi4 family NAD_binding_7 PF13241.6 ACT00976.1 - 0.042 14.3 1.4 0.57 10.6 0.1 2.7 3 1 0 3 3 2 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 ACT00976.1 - 0.043 13.2 0.7 0.086 12.2 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 ACT00976.1 - 0.23 10.5 4.2 1.7 7.6 0.2 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein E1_dh PF00676.20 ACT00977.1 - 5.6e-93 311.2 0.0 6.4e-93 311.0 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_N PF00456.21 ACT00977.1 - 0.0014 17.6 0.0 0.0024 16.9 0.0 1.4 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain TPP_enzyme_C PF02775.21 ACT00977.1 - 0.0039 17.0 0.6 0.12 12.2 0.1 2.7 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 ACT00977.1 - 0.011 14.9 0.0 0.083 12.1 0.0 2.0 1 1 1 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 ACT00978.1 - 2.9e-49 167.2 0.0 7.1e-49 165.9 0.0 1.6 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ACT00978.1 - 7.5e-38 129.2 0.0 1.2e-37 128.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 ACT00978.1 - 0.0013 19.0 0.0 0.0025 18.1 0.0 1.4 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Tim17 PF02466.19 ACT00978.1 - 0.017 15.5 0.3 0.15 12.4 0.1 2.1 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family BPL_LplA_LipB PF03099.19 ACT00979.1 - 3.3e-09 36.8 0.0 5.2e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Peptidase_M20 PF01546.28 ACT00980.1 - 2.2e-24 86.3 0.5 3.2e-24 85.8 0.5 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ACT00980.1 - 4e-16 58.9 0.2 3.5e-15 55.9 0.1 2.2 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M42 PF05343.14 ACT00980.1 - 6e-15 55.0 0.1 4.6e-08 32.4 0.0 3.3 2 1 0 3 3 3 3 M42 glutamyl aminopeptidase Peptidase_M28 PF04389.17 ACT00980.1 - 3e-14 53.2 0.1 7.7e-11 42.1 0.1 2.3 2 0 0 2 2 2 2 Peptidase family M28 WPP PF13943.6 ACT00980.1 - 0.085 13.3 0.0 0.25 11.8 0.0 1.8 1 0 0 1 1 1 0 WPP domain DUF374 PF04028.13 ACT00980.1 - 0.1 12.2 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF374) MciZ PF13072.6 ACT00981.1 - 5.8e-07 29.2 0.3 6.9e-07 29.0 0.3 1.1 1 0 0 1 1 1 1 Mother cell inhibitor of FtsZ NUDIX PF00293.28 ACT00982.1 - 1.2e-18 67.4 0.1 1.5e-18 67.1 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain TPR_19 PF14559.6 ACT00982.1 - 0.063 13.8 0.3 0.13 12.8 0.3 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat SpoIIM PF01944.17 ACT00983.1 - 6e-25 88.1 12.2 7.6e-25 87.8 12.2 1.1 1 0 0 1 1 1 1 Stage II sporulation protein M Gly-zipper_Omp PF13488.6 ACT00983.1 - 0.018 15.0 0.3 0.9 9.6 0.0 2.4 2 0 0 2 2 2 0 Glycine zipper LapA_dom PF06305.11 ACT00983.1 - 0.12 12.2 0.1 0.12 12.2 0.1 3.2 3 1 0 3 3 3 0 Lipopolysaccharide assembly protein A domain MaAIMP_sms PF16951.5 ACT00983.1 - 0.24 11.2 0.1 0.24 11.2 0.1 2.0 2 0 0 2 2 2 0 Putative methionine and alanine importer, small subunit Gly-zipper_YMGG PF13441.6 ACT00983.1 - 0.44 10.3 2.4 1.5 8.7 0.1 2.4 2 0 0 2 2 2 0 YMGG-like Gly-zipper Phage_holin_6_1 PF09682.10 ACT00983.1 - 0.69 10.4 3.2 15 6.1 0.1 2.3 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) FUR PF01475.19 ACT00984.1 - 5.5e-38 129.8 0.1 7.3e-38 129.4 0.1 1.2 1 0 0 1 1 1 1 Ferric uptake regulator family Peptidase_S8 PF00082.22 ACT00985.1 - 9.6e-52 176.1 9.1 1.4e-51 175.5 9.1 1.3 1 0 0 1 1 1 1 Subtilase family AlaDh_PNT_C PF01262.21 ACT00986.1 - 7.5e-81 270.5 3.7 9.7e-81 270.1 3.7 1.1 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 ACT00986.1 - 2.4e-48 163.9 0.1 6.4e-48 162.5 0.0 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain 2-Hacid_dh_C PF02826.19 ACT00986.1 - 1.5e-06 27.7 0.3 4e-06 26.3 0.2 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ACT00986.1 - 3.7e-05 23.8 0.1 6.7e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 ACT00986.1 - 7.7e-05 22.1 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT00986.1 - 0.00023 21.6 0.2 0.00069 20.1 0.2 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ACT00986.1 - 0.0012 18.3 2.1 0.0018 17.7 2.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 ACT00986.1 - 0.0015 17.7 0.4 0.0019 17.3 0.4 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A IlvN PF07991.12 ACT00986.1 - 0.0034 17.0 0.5 0.025 14.1 0.1 2.2 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 ACT00986.1 - 0.0047 17.1 0.6 0.01 16.0 0.6 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DAO PF01266.24 ACT00986.1 - 0.0094 15.6 1.4 0.017 14.7 1.4 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase 3HCDH_N PF02737.18 ACT00986.1 - 0.03 14.2 0.5 0.051 13.5 0.5 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ACT00986.1 - 0.031 14.7 0.1 0.071 13.6 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 ACT00986.1 - 0.036 13.3 0.5 0.053 12.8 0.5 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 ACT00986.1 - 0.078 11.7 0.8 0.16 10.7 0.6 1.5 2 0 0 2 2 2 0 HI0933-like protein TrkA_N PF02254.18 ACT00986.1 - 0.11 12.7 0.1 0.21 11.9 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain FAD_binding_2 PF00890.24 ACT00986.1 - 0.13 11.4 1.5 0.21 10.6 1.5 1.3 1 0 0 1 1 1 0 FAD binding domain DUF4227 PF14004.6 ACT00987.1 - 3.1e-24 84.7 0.1 3.4e-24 84.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4227) Phage_integrase PF00589.22 ACT00988.1 - 4.7e-47 160.0 0.2 7.8e-47 159.2 0.0 1.5 2 0 0 2 2 2 1 Phage integrase family Phage_int_SAM_1 PF02899.17 ACT00988.1 - 5.3e-19 68.3 3.0 1.4e-18 67.0 1.3 2.3 2 1 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 ACT00988.1 - 1.3e-08 35.2 0.7 5.2e-08 33.3 0.2 2.3 2 1 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain DUF3435 PF11917.8 ACT00988.1 - 7.3e-05 21.9 0.0 0.00015 20.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_int_SAM_5 PF13102.6 ACT00988.1 - 0.00034 20.9 0.1 0.0075 16.6 0.0 2.8 2 1 0 2 2 2 1 Phage integrase SAM-like domain Metalloenzyme PF01676.18 ACT00989.1 - 3.9e-32 111.6 0.0 5.4e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 ACT00989.1 - 8.1e-05 22.1 0.0 0.023 14.1 0.0 2.3 1 1 1 2 2 2 2 Sulfatase Phosphodiest PF01663.22 ACT00989.1 - 0.0041 16.8 0.0 0.0049 16.5 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PNP_UDP_1 PF01048.20 ACT00990.1 - 6.9e-51 172.8 0.6 7.8e-51 172.6 0.6 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily DUF5028 PF16431.5 ACT00990.1 - 0.097 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5028) SpoOE-like PF09388.10 ACT00991.1 - 4.1e-13 49.0 2.1 5.4e-13 48.6 2.1 1.3 1 0 0 1 1 1 1 Spo0E like sporulation regulatory protein Glycos_transf_3 PF00591.21 ACT00992.1 - 7.1e-44 150.3 8.1 1e-43 149.8 8.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 ACT00992.1 - 3.3e-25 87.7 0.1 1.4e-24 85.7 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain PYNP_C PF07831.13 ACT00992.1 - 3.2e-24 84.4 1.1 9.7e-24 82.8 1.1 1.9 1 0 0 1 1 1 1 Pyrimidine nucleoside phosphorylase C-terminal domain DUF2118 PF09891.9 ACT00992.1 - 0.014 15.3 0.0 0.74 9.8 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) Biotin_lipoyl PF00364.22 ACT00992.1 - 0.02 14.7 0.1 0.31 10.9 0.0 2.8 2 0 0 2 2 2 0 Biotin-requiring enzyme DUF2254 PF10011.9 ACT00992.1 - 0.056 12.3 0.2 0.22 10.3 0.2 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2254) Peptidase_S11 PF00768.20 ACT00993.1 - 1.1e-80 270.5 1.5 1.6e-80 270.0 1.5 1.2 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase PBP5_C PF07943.13 ACT00993.1 - 1.4e-15 57.3 0.7 2.5e-15 56.5 0.3 1.7 2 0 0 2 2 2 1 Penicillin-binding protein 5, C-terminal domain Beta-lactamase2 PF13354.6 ACT00993.1 - 1e-10 41.6 0.1 1.5e-10 41.0 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase enzyme family Beta-lactamase PF00144.24 ACT00993.1 - 5.5e-05 22.6 0.1 0.00043 19.6 0.0 2.0 1 1 1 2 2 2 1 Beta-lactamase Peptidase_S13 PF02113.15 ACT00993.1 - 0.0029 16.4 0.5 0.0051 15.6 0.1 1.5 2 0 0 2 2 2 1 D-Ala-D-Ala carboxypeptidase 3 (S13) family STAS PF01740.21 ACT00994.1 - 1.2e-22 79.7 0.0 1.4e-22 79.5 0.0 1.0 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 ACT00994.1 - 1e-10 41.8 0.0 1.4e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 STAS domain HATPase_c_2 PF13581.6 ACT00995.1 - 5.6e-23 81.3 0.0 6.3e-23 81.1 0.0 1.0 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c PF02518.26 ACT00995.1 - 2e-11 44.4 0.0 2.5e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT00995.1 - 0.00041 20.2 0.0 0.00065 19.5 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FlgO PF17680.1 ACT00995.1 - 0.1 12.3 0.1 0.43 10.3 0.0 1.8 2 0 0 2 2 2 0 FlgO protein Pentaxin PF00354.17 ACT00995.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Pentaxin family Sigma70_r4 PF04545.16 ACT00996.1 - 4.4e-18 64.5 4.8 2e-15 56.0 3.1 2.7 3 0 0 3 3 2 2 Sigma-70, region 4 Sigma70_r3 PF04539.16 ACT00996.1 - 1.6e-17 63.4 0.4 1.1e-14 54.3 0.2 2.4 2 0 0 2 2 2 1 Sigma-70 region 3 Sigma70_r2 PF04542.14 ACT00996.1 - 2.5e-17 62.4 0.0 5.5e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT00996.1 - 1.6e-09 37.3 1.6 1.6e-08 34.1 1.1 2.5 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_3 PF01381.22 ACT00996.1 - 1.9e-05 24.6 0.4 0.00078 19.5 0.5 2.6 2 0 0 2 2 2 1 Helix-turn-helix KORA PF16509.5 ACT00996.1 - 2e-05 24.8 0.6 0.00018 21.7 0.2 2.6 3 0 0 3 3 3 1 TrfB plasmid transcriptional repressor HTH_23 PF13384.6 ACT00996.1 - 4.1e-05 23.2 2.4 0.0037 17.0 0.8 3.1 3 0 0 3 3 3 1 Homeodomain-like domain MarR_2 PF12802.7 ACT00996.1 - 0.00025 20.9 0.1 0.48 10.4 0.0 2.7 2 0 0 2 2 2 2 MarR family HTH_31 PF13560.6 ACT00996.1 - 0.0014 18.9 0.3 0.014 15.8 0.2 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_37 PF13744.6 ACT00996.1 - 0.0016 18.3 0.1 0.0068 16.3 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT00996.1 - 0.0036 17.3 0.0 0.46 10.5 0.0 2.6 2 1 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_8 PF02954.19 ACT00996.1 - 0.0076 16.0 0.0 4 7.3 0.0 2.7 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family HTH_10 PF04967.12 ACT00996.1 - 0.009 15.8 0.0 1.2 8.9 0.1 2.8 2 0 0 2 2 2 1 HTH DNA binding domain Sigma70_ECF PF07638.11 ACT00996.1 - 0.017 15.0 0.3 2.5 8.0 0.1 2.5 3 0 0 3 3 3 0 ECF sigma factor HTH_19 PF12844.7 ACT00996.1 - 0.017 15.1 0.3 0.22 11.5 0.2 2.5 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_38 PF13936.6 ACT00996.1 - 0.018 14.8 0.1 0.24 11.2 0.2 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_26 PF13443.6 ACT00996.1 - 0.02 15.3 0.1 0.98 9.9 0.1 2.5 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain HTH_28 PF13518.6 ACT00996.1 - 0.021 14.9 0.1 0.7 10.1 0.2 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.6 ACT00996.1 - 0.025 14.1 1.4 8.8 6.0 0.2 3.8 3 1 1 4 4 4 0 Winged helix-turn-helix DNA-binding Trp_repressor PF01371.19 ACT00996.1 - 0.031 14.4 0.7 0.095 12.8 0.5 1.9 2 0 0 2 2 2 0 Trp repressor protein HTH_17 PF12728.7 ACT00996.1 - 0.052 13.7 0.3 22 5.3 0.0 3.0 3 0 0 3 3 2 0 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 ACT00996.1 - 0.059 13.7 0.3 12 6.3 0.1 2.8 2 1 1 3 3 3 0 Transposase DUF722 PF05263.11 ACT00996.1 - 0.067 13.4 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF722) HTH_25 PF13413.6 ACT00996.1 - 0.087 12.7 0.1 0.8 9.6 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain GerE PF00196.19 ACT00996.1 - 0.092 12.3 0.0 1.4 8.5 0.1 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family YdaS_antitoxin PF15943.5 ACT00996.1 - 0.13 12.1 0.0 4.5 7.2 0.1 2.4 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT AAA_18 PF13238.6 ACT00997.1 - 5.1e-07 30.3 0.1 1.5e-06 28.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain SKI PF01202.22 ACT00997.1 - 0.00029 21.0 0.0 0.00062 19.9 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 ACT00997.1 - 0.00052 20.2 0.0 0.0011 19.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 ACT00997.1 - 0.0011 19.1 0.0 0.0016 18.6 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase-like family dNK PF01712.19 ACT00997.1 - 0.0019 18.1 0.1 0.011 15.5 0.0 2.0 1 1 0 2 2 2 1 Deoxynucleoside kinase PduV-EutP PF10662.9 ACT00997.1 - 0.002 17.9 0.0 0.0033 17.2 0.0 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation CoaE PF01121.20 ACT00997.1 - 0.0067 16.1 0.1 0.11 12.1 0.0 2.1 2 0 0 2 2 2 1 Dephospho-CoA kinase AAA_28 PF13521.6 ACT00997.1 - 0.0087 16.3 0.0 0.017 15.4 0.0 1.6 2 0 0 2 2 2 1 AAA domain KTI12 PF08433.10 ACT00997.1 - 0.019 14.4 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 APS_kinase PF01583.20 ACT00997.1 - 0.023 14.6 0.0 0.14 12.1 0.0 2.0 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_17 PF13207.6 ACT00997.1 - 0.024 15.1 0.0 0.049 14.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ACT00997.1 - 0.033 14.0 0.1 0.48 10.2 0.1 2.2 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein CPT PF07931.12 ACT00997.1 - 0.04 13.7 0.0 0.052 13.4 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_22 PF13401.6 ACT00997.1 - 0.045 14.0 0.0 0.058 13.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain MobB PF03205.14 ACT00997.1 - 0.051 13.5 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.6 ACT00997.1 - 0.054 13.5 0.0 0.084 12.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 ACT00997.1 - 0.061 12.6 0.0 0.083 12.2 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase SRPRB PF09439.10 ACT00997.1 - 0.12 11.8 0.1 0.22 11.0 0.1 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ACT00997.1 - 0.12 12.4 0.0 0.28 11.3 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA PF00004.29 ACT00997.1 - 0.16 12.4 0.0 0.25 11.7 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 ACT00997.1 - 0.16 11.5 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 ACT00998.1 - 0.00033 20.8 0.1 0.12 12.5 0.2 2.4 2 1 1 3 3 2 1 AAA domain PRK PF00485.18 ACT00998.1 - 0.00084 19.1 0.0 0.03 14.1 0.0 2.1 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family SKI PF01202.22 ACT00998.1 - 0.0063 16.7 0.0 0.032 14.4 0.0 2.1 3 0 0 3 3 2 1 Shikimate kinase AAA_18 PF13238.6 ACT00998.1 - 0.012 16.1 0.0 0.024 15.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ACT00998.1 - 0.013 15.2 0.1 0.041 13.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 ACT00998.1 - 0.015 15.4 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain dNK PF01712.19 ACT00998.1 - 0.015 15.2 0.4 2.8 7.8 0.1 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase ABC_tran PF00005.27 ACT00998.1 - 0.018 15.6 0.4 0.019 15.5 0.4 1.5 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 ACT00998.1 - 0.019 15.2 0.0 0.045 14.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 ACT00998.1 - 0.022 14.7 0.0 0.03 14.2 0.0 1.2 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 DUF87 PF01935.17 ACT00998.1 - 0.025 14.7 0.4 0.074 13.1 0.2 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain NB-ARC PF00931.22 ACT00998.1 - 0.028 13.6 0.0 0.045 12.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain MMR_HSR1 PF01926.23 ACT00998.1 - 0.038 14.1 0.1 0.092 12.8 0.1 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 ACT00998.1 - 0.051 14.0 0.0 0.095 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 ACT00998.1 - 0.051 13.8 0.0 0.078 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 ACT00998.1 - 0.058 13.1 0.9 0.13 11.9 0.1 1.9 2 1 1 3 3 3 0 Cytidylate kinase IstB_IS21 PF01695.17 ACT00998.1 - 0.062 13.0 0.0 0.67 9.7 0.1 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein Thymidylate_kin PF02223.17 ACT00998.1 - 0.075 12.7 0.0 2.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Thymidylate kinase RsgA_GTPase PF03193.16 ACT00998.1 - 0.088 12.7 0.1 0.19 11.6 0.0 1.5 2 0 0 2 2 2 0 RsgA GTPase Zeta_toxin PF06414.12 ACT00998.1 - 0.092 12.0 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 ACT00998.1 - 0.11 12.4 0.3 0.2 11.6 0.1 1.5 2 0 0 2 2 2 0 NACHT domain MeaB PF03308.16 ACT00998.1 - 0.12 11.3 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 ACT00998.1 - 0.14 11.6 0.1 0.32 10.4 0.1 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_16 PF13191.6 ACT00998.1 - 0.15 12.5 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 ACT00998.1 - 0.16 11.9 0.2 2.1 8.4 0.1 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ParA PF10609.9 ACT00998.1 - 0.19 11.1 0.0 0.3 10.5 0.0 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase SporV_AA PF12164.8 ACT00999.1 - 1.1e-18 67.3 0.0 2.1e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Stage V sporulation protein AA Peptidase_U4 PF03419.13 ACT00999.1 - 0.15 11.3 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA SpoVAB PF13782.6 ACT01000.1 - 1.2e-32 112.5 4.7 1.2e-32 112.5 4.7 1.9 2 0 0 2 2 2 1 Stage V sporulation protein AB GerA PF03323.13 ACT01001.1 - 1.3e-152 508.5 1.0 1.6e-152 508.3 1.0 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Orn_Arg_deC_N PF02784.16 ACT01002.1 - 3e-68 229.8 0.1 3.9e-68 229.5 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 ACT01002.1 - 8.3e-17 61.2 0.0 1.2e-16 60.7 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ala_racemase_N PF01168.20 ACT01002.1 - 0.00044 20.0 0.1 0.0011 18.6 0.1 1.5 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain Pro_isomerase PF00160.21 ACT01003.1 - 2.6e-41 141.5 0.3 3.1e-41 141.3 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RibD_C PF01872.17 ACT01004.1 - 2.8e-53 180.7 0.2 7.6e-53 179.3 0.2 1.6 2 0 0 2 2 2 1 RibD C-terminal domain dCMP_cyt_deam_1 PF00383.23 ACT01004.1 - 3.1e-21 75.1 0.3 7.1e-21 74.0 0.3 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ACT01004.1 - 5.7e-13 48.8 0.0 1.1e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 MafB19-like deaminase Inv-AAD PF18785.1 ACT01004.1 - 1.3e-05 25.0 0.5 4.5e-05 23.3 0.2 2.1 2 1 0 2 2 2 1 Invertebrate-AID/APOBEC-deaminase Lum_binding PF00677.17 ACT01005.1 - 1.8e-49 165.6 2.6 9.6e-24 83.2 0.3 2.1 2 0 0 2 2 2 2 Lumazine binding domain Catalase_C PF18011.1 ACT01005.1 - 0.025 14.2 0.1 2.1 8.0 0.0 2.1 2 0 0 2 2 2 0 C-terminal domain found in long catalases DHBP_synthase PF00926.19 ACT01006.1 - 4.1e-84 280.9 0.2 5.3e-84 280.5 0.2 1.1 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase GTP_cyclohydro2 PF00925.20 ACT01006.1 - 3.3e-62 208.9 0.0 5.8e-62 208.1 0.0 1.4 1 0 0 1 1 1 1 GTP cyclohydrolase II DMRL_synthase PF00885.19 ACT01007.1 - 1.1e-58 197.1 0.1 1.2e-58 196.9 0.1 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase PucR PF07905.11 ACT01007.1 - 0.064 13.5 0.0 0.14 12.4 0.0 1.6 1 1 1 2 2 2 0 Purine catabolism regulatory protein-like family SMC_ScpA PF02616.14 ACT01008.1 - 1.6e-42 146.1 8.6 2.6e-42 145.4 8.6 1.3 1 0 0 1 1 1 1 Segregation and condensation protein ScpA Rad21_Rec8 PF04824.16 ACT01008.1 - 0.035 13.4 0.0 0.067 12.5 0.0 1.4 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein SMC_ScpB PF04079.16 ACT01009.1 - 8.1e-55 184.8 0.0 1e-54 184.5 0.0 1.1 1 0 0 1 1 1 1 Segregation and condensation complex subunit ScpB ABC_tran PF00005.27 ACT01010.1 - 2e-37 128.8 0.1 3.3e-37 128.0 0.1 1.4 1 0 0 1 1 1 1 ABC transporter NIL PF09383.10 ACT01010.1 - 1.3e-17 63.4 0.1 2.4e-17 62.6 0.1 1.4 1 0 0 1 1 1 1 NIL domain AAA_21 PF13304.6 ACT01010.1 - 4.7e-07 29.9 0.2 0.027 14.3 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT01010.1 - 0.00012 21.6 1.0 0.002 17.6 1.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT01010.1 - 0.00014 22.2 1.5 0.002 18.4 1.5 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT01010.1 - 0.00014 22.3 0.1 0.00047 20.6 0.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ACT01010.1 - 0.0016 18.1 0.1 0.0035 17.1 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACT01010.1 - 0.0019 18.7 0.6 0.0051 17.3 0.6 1.6 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT01010.1 - 0.0084 16.0 0.1 0.015 15.2 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase ABC_ATPase PF09818.9 ACT01010.1 - 0.025 13.4 1.3 1.6 7.4 0.2 2.4 2 1 0 2 2 2 0 Predicted ATPase of the ABC class GTP_EFTU PF00009.27 ACT01010.1 - 0.048 13.2 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ACT01010.1 - 0.084 13.0 0.0 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 ACT01010.1 - 0.15 11.8 0.1 0.7 9.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ACT01010.1 - 0.16 12.1 0.2 0.38 10.9 0.2 1.5 1 1 0 1 1 1 0 AAA domain BPD_transp_1 PF00528.22 ACT01011.1 - 6.4e-20 71.7 17.8 6.4e-20 71.7 17.8 1.7 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SecE PF00584.20 ACT01011.1 - 0.0038 17.1 1.0 0.0038 17.1 1.0 3.6 4 1 0 4 4 4 1 SecE/Sec61-gamma subunits of protein translocation complex YqgB PF11036.8 ACT01011.1 - 0.0041 16.8 0.1 0.009 15.7 0.1 1.5 1 0 0 1 1 1 1 Virulence promoting factor PHO4 PF01384.20 ACT01011.1 - 0.043 12.9 7.5 0.085 11.9 7.5 1.6 1 1 0 1 1 1 0 Phosphate transporter family Lipoprotein_9 PF03180.14 ACT01012.1 - 2.6e-101 337.7 1.5 3.1e-101 337.4 1.5 1.0 1 0 0 1 1 1 1 NLPA lipoprotein LPAM_1 PF08139.12 ACT01012.1 - 1.1 9.9 9.0 0.13 12.8 4.2 2.0 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site DUF2953 PF11167.8 ACT01013.1 - 2.4e-15 56.3 0.1 2.9e-14 52.8 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF2953) Spore_YtfJ PF09579.10 ACT01014.1 - 1.6e-27 95.4 1.0 3.6e-27 94.3 1.0 1.6 1 1 0 1 1 1 1 Sporulation protein YtfJ (Spore_YtfJ) Peptidase_S11 PF00768.20 ACT01015.1 - 7e-66 222.1 0.8 9.3e-66 221.7 0.8 1.1 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 ACT01015.1 - 7.3e-07 29.0 0.1 1.1e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase enzyme family Peptidase_S13 PF02113.15 ACT01015.1 - 0.00046 19.0 0.0 0.00094 18.0 0.0 1.5 1 1 0 1 1 1 1 D-Ala-D-Ala carboxypeptidase 3 (S13) family Beta-lactamase PF00144.24 ACT01015.1 - 0.0077 15.5 0.3 0.96 8.6 0.0 3.0 2 1 1 3 3 3 1 Beta-lactamase Gate PF07670.14 ACT01016.1 - 9.5e-11 42.0 1.3 9.5e-11 42.0 1.3 1.6 2 0 0 2 2 2 1 Nucleoside recognition DUF4293 PF14126.6 ACT01016.1 - 1.6 8.9 4.4 0.73 10.1 1.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) Gate PF07670.14 ACT01017.1 - 0.0033 17.7 2.2 0.0033 17.7 2.2 2.0 2 0 0 2 2 2 1 Nucleoside recognition PseudoU_synth_2 PF00849.22 ACT01018.1 - 1.5e-21 77.1 0.0 6.6e-21 75.1 0.0 1.9 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 ACT01018.1 - 4.3e-13 48.8 0.6 1.4e-11 43.9 0.1 2.4 1 1 1 2 2 2 2 S4 domain AhpC-TSA PF00578.21 ACT01019.1 - 9.2e-32 109.6 0.0 1.1e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ACT01019.1 - 9.8e-28 96.7 0.0 1.1e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 ACT01019.1 - 1.3e-11 44.6 0.0 1.9e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 ACT01019.1 - 1.2e-07 31.7 0.0 0.00029 20.8 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 ACT01019.1 - 1.1e-06 29.1 0.0 1.9e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 ACT01019.1 - 0.00016 21.6 0.0 0.00027 20.8 0.0 1.3 1 1 0 1 1 1 1 F plasmid transfer operon protein GSHPx PF00255.19 ACT01019.1 - 0.00024 20.6 0.0 0.00037 20.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase T4_deiodinase PF00837.17 ACT01019.1 - 0.0023 17.3 0.0 0.003 16.9 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase SCO1-SenC PF02630.14 ACT01019.1 - 0.0028 17.6 0.0 0.0069 16.3 0.0 1.5 1 1 1 2 2 2 1 SCO1/SenC Peripla_BP_6 PF13458.6 ACT01019.1 - 0.0094 15.6 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein AhpC-TSA_2 PF13911.6 ACT01019.1 - 0.11 12.6 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme ResB PF05140.14 ACT01020.1 - 1e-93 314.8 0.0 7.7e-74 249.2 0.0 2.0 1 1 1 2 2 2 2 ResB-like family CcmF_C PF16327.5 ACT01020.1 - 0.0024 17.2 1.2 0.043 13.1 0.0 2.7 3 0 0 3 3 3 1 Cytochrome c-type biogenesis protein CcmF C-terminal Toprim_C_rpt PF13368.6 ACT01020.1 - 0.14 12.2 0.0 0.44 10.6 0.0 1.9 1 0 0 1 1 1 0 Topoisomerase C-terminal repeat zinc_ribbon_2 PF13240.6 ACT01020.1 - 0.19 11.5 3.5 0.42 10.4 3.5 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Cytochrom_C_asm PF01578.20 ACT01021.1 - 1.2e-38 133.0 29.7 1e-28 100.6 10.8 3.1 3 0 0 3 3 3 3 Cytochrome C assembly protein DUF3810 PF12725.7 ACT01021.1 - 0.019 14.3 0.1 0.019 14.3 0.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF3810) Synaptobrevin PF00957.21 ACT01021.1 - 0.026 14.3 0.3 0.026 14.3 0.3 3.3 3 0 0 3 3 3 0 Synaptobrevin TMEM132D_C PF15706.5 ACT01021.1 - 0.24 11.2 4.8 0.82 9.5 0.0 3.4 3 1 1 4 4 4 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF5345 PF17280.2 ACT01021.1 - 4.1 7.4 10.3 7.3 6.6 1.6 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5345) Response_reg PF00072.24 ACT01022.1 - 1.2e-30 106.0 0.1 2.2e-30 105.1 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT01022.1 - 1.7e-28 98.5 0.0 3.5e-28 97.5 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal GerE PF00196.19 ACT01022.1 - 0.019 14.5 0.1 3.3 7.3 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Imm65 PF15582.6 ACT01022.1 - 0.065 12.1 0.2 4.3 6.1 0.0 2.7 3 0 0 3 3 3 0 Immunity protein 65 HATPase_c PF02518.26 ACT01023.1 - 7.2e-26 90.9 0.1 1.6e-25 89.8 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT01023.1 - 5.1e-21 74.5 2.4 7e-21 74.0 0.1 2.4 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT01023.1 - 4.4e-15 55.8 0.0 1.4e-14 54.2 0.0 1.9 1 0 0 1 1 1 1 HAMP domain PAS_4 PF08448.10 ACT01023.1 - 2.7e-05 24.4 0.1 5.5e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.6 ACT01023.1 - 0.0048 16.7 0.1 0.0088 15.9 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT01023.1 - 0.032 14.2 0.3 0.099 12.6 0.3 1.8 1 1 0 1 1 1 0 GHKL domain 7tm_1 PF00001.21 ACT01023.1 - 0.055 12.8 0.0 0.055 12.8 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) SesA PF17107.5 ACT01023.1 - 0.056 13.6 0.4 15 5.8 0.0 2.8 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Halogen_Hydrol PF10112.9 ACT01023.1 - 0.15 12.0 0.0 0.15 12.0 0.0 2.3 2 1 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF1240 PF06836.12 ACT01023.1 - 0.36 11.4 2.5 0.94 10.1 2.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1240) ABC2_membrane_3 PF12698.7 ACT01023.1 - 0.7 8.9 8.1 1.2 8.2 8.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein RseC_MucC PF04246.12 ACT01023.1 - 0.87 9.5 4.3 1.7 8.6 4.3 1.4 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC DUF2614 PF11023.8 ACT01023.1 - 4.2 7.5 5.6 7.6 6.7 5.6 1.3 1 0 0 1 1 1 0 Zinc-ribbon containing domain ArsB PF02040.15 ACT01024.1 - 5.9e-61 207.1 35.5 7.9e-61 206.6 35.5 1.1 1 0 0 1 1 1 1 Arsenical pump membrane protein CitMHS PF03600.16 ACT01024.1 - 5e-24 85.0 40.4 5e-24 85.0 40.4 2.1 1 1 1 2 2 2 2 Citrate transporter Na_sulph_symp PF00939.19 ACT01024.1 - 0.0013 17.8 46.0 0.0035 16.4 10.8 3.0 1 1 1 2 2 2 2 Sodium:sulfate symporter transmembrane region 2-Hacid_dh_C PF02826.19 ACT01025.1 - 3.5e-64 215.4 0.0 6.6e-64 214.5 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ACT01025.1 - 1.4e-34 118.6 0.1 2.6e-34 117.7 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 ACT01025.1 - 1.4e-09 37.5 0.2 4.1e-09 36.1 0.2 1.9 1 0 0 1 1 1 1 ACT domain IlvN PF07991.12 ACT01025.1 - 8.9e-05 22.1 0.1 0.00026 20.6 0.0 1.8 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 ACT01025.1 - 0.00017 21.8 0.2 0.00037 20.7 0.2 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_C PF03720.15 ACT01025.1 - 0.017 15.5 0.0 0.06 13.8 0.0 1.9 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain F420_oxidored PF03807.17 ACT01025.1 - 0.032 14.8 0.0 0.14 12.8 0.0 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ACT_4 PF13291.6 ACT01025.1 - 0.6 10.7 4.1 0.46 11.1 0.2 2.6 3 0 0 3 3 3 0 ACT domain Rhodanese PF00581.20 ACT01026.1 - 2.2e-09 37.8 0.0 2.9e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain Chromo_shadow PF01393.19 ACT01026.1 - 0.061 13.4 0.0 0.5 10.5 0.0 2.1 2 0 0 2 2 2 0 Chromo shadow domain IFT81_CH PF18383.1 ACT01026.1 - 0.082 13.2 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Intraflagellar transport 81 calponin homology domain T7SS_ESX_EspC PF10824.8 ACT01027.1 - 2.4 8.7 9.9 4 8.0 2.6 2.6 2 1 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm CPBP PF02517.16 ACT01028.1 - 2.2e-13 50.4 5.7 2.2e-13 50.4 5.7 2.1 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease DUF751 PF05421.11 ACT01028.1 - 0.89 10.3 5.1 0.91 10.3 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF751) Polysacc_deac_1 PF01522.21 ACT01030.1 - 1.4e-31 109.0 0.0 1.9e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase MecA PF05389.12 ACT01032.1 - 3.8e-42 144.5 0.8 1.7e-40 139.0 0.8 2.0 1 1 0 1 1 1 1 Negative regulator of genetic competence (MecA) Ufm1 PF03671.14 ACT01032.1 - 0.088 12.9 0.0 0.46 10.6 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin fold modifier 1 protein ELFV_dehydrog PF00208.21 ACT01033.1 - 1.3e-73 247.7 0.0 2.2e-73 246.9 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 ACT01033.1 - 7.5e-54 181.1 0.0 1.3e-53 180.3 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2-Hacid_dh_C PF02826.19 ACT01033.1 - 0.0036 16.7 0.0 0.0061 15.9 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 ACT01033.1 - 0.095 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Baculo_DNA_bind PF04786.12 ACT01033.1 - 0.15 11.4 0.1 0.24 10.7 0.1 1.2 1 0 0 1 1 1 0 ssDNA binding protein PrsW-protease PF13367.6 ACT01034.1 - 6.3e-40 136.7 10.8 8.5e-40 136.3 10.8 1.1 1 0 0 1 1 1 1 PrsW family intramembrane metalloprotease DUF2085 PF09858.9 ACT01034.1 - 0.017 15.6 1.5 0.017 15.6 1.5 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2085) PrgI PF12666.7 ACT01034.1 - 0.38 11.5 11.6 4 8.2 1.2 2.9 2 1 1 3 3 3 0 PrgI family protein YPEB PF14620.6 ACT01036.1 - 2.2e-130 435.2 7.3 2.6e-130 435.0 7.3 1.1 1 0 0 1 1 1 1 YpeB sporulation PepSY PF03413.19 ACT01036.1 - 0.0068 16.9 0.6 0.046 14.3 0.0 2.6 2 1 0 2 2 2 1 Peptidase propeptide and YPEB domain DUF2935 PF11155.8 ACT01036.1 - 0.038 14.3 0.0 0.11 12.8 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) PilZ PF07238.14 ACT01037.1 - 1e-13 51.5 0.0 1.2e-10 41.6 0.0 2.1 2 0 0 2 2 2 2 PilZ domain YcgR_2 PF12945.7 ACT01037.1 - 1.2e-11 44.6 0.0 2.5e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Flagellar protein YcgR DUF4947 PF16305.5 ACT01037.1 - 0.15 12.0 0.0 0.65 10.0 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4947) E1-E2_ATPase PF00122.20 ACT01038.1 - 0.016 14.7 0.0 0.019 14.5 0.0 1.0 1 0 0 1 1 1 0 E1-E2 ATPase DUF5359 PF17313.2 ACT01038.1 - 0.044 13.8 0.0 0.055 13.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5359) Cytidylate_kin PF02224.18 ACT01039.1 - 4.1e-76 255.4 3.2 4.7e-76 255.2 3.2 1.0 1 0 0 1 1 1 1 Cytidylate kinase Cytidylate_kin2 PF13189.6 ACT01039.1 - 4.2e-14 53.1 1.2 7.6e-14 52.2 1.2 1.4 1 0 0 1 1 1 1 Cytidylate kinase-like family AAA_18 PF13238.6 ACT01039.1 - 1.6e-08 35.2 0.0 1.3e-07 32.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ACT01039.1 - 1.7e-06 28.5 1.6 8.6e-05 23.0 1.6 2.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACT01039.1 - 4.7e-06 26.9 0.1 1e-05 25.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ACT01039.1 - 4.8e-06 26.8 1.0 2.6e-05 24.4 1.0 2.3 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 ACT01039.1 - 9.4e-06 25.8 2.1 0.00093 19.3 0.0 2.6 1 1 1 2 2 2 1 Shikimate kinase ADK PF00406.22 ACT01039.1 - 0.00035 20.7 0.0 0.0017 18.5 0.0 2.0 2 0 0 2 2 2 1 Adenylate kinase Thymidylate_kin PF02223.17 ACT01039.1 - 0.0017 18.0 0.1 0.62 9.7 0.0 2.5 2 1 0 2 2 2 1 Thymidylate kinase NB-ARC PF00931.22 ACT01039.1 - 0.0018 17.5 0.1 0.006 15.8 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain NTPase_1 PF03266.15 ACT01039.1 - 0.0029 17.5 0.0 0.017 15.0 0.0 2.1 2 0 0 2 2 2 1 NTPase AAA_30 PF13604.6 ACT01039.1 - 0.0031 17.2 2.7 0.036 13.8 0.3 2.4 1 1 1 2 2 2 1 AAA domain NACHT PF05729.12 ACT01039.1 - 0.0041 17.1 0.1 0.11 12.4 0.0 2.1 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 ACT01039.1 - 0.0063 16.9 1.1 0.018 15.4 1.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ACT01039.1 - 0.0064 16.5 0.4 1.8 8.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ACT01039.1 - 0.0067 16.9 0.5 0.016 15.6 0.5 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MipZ PF09140.11 ACT01039.1 - 0.019 14.2 0.6 0.61 9.3 0.1 2.3 1 1 1 2 2 2 0 ATPase MipZ AAA_28 PF13521.6 ACT01039.1 - 0.038 14.2 0.4 0.12 12.6 0.0 2.0 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ACT01039.1 - 0.04 14.4 0.1 0.08 13.5 0.1 1.8 1 1 0 1 1 1 0 ABC transporter dNK PF01712.19 ACT01039.1 - 0.051 13.4 0.1 0.23 11.3 0.0 2.0 2 0 0 2 2 2 0 Deoxynucleoside kinase PRK PF00485.18 ACT01039.1 - 0.073 12.8 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_24 PF13479.6 ACT01039.1 - 0.08 12.7 0.0 0.19 11.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 ACT01039.1 - 0.085 12.6 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CobU PF02283.16 ACT01039.1 - 0.088 12.4 0.4 0.52 9.9 0.4 2.4 1 1 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase TsaE PF02367.17 ACT01039.1 - 0.1 12.6 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Acyltransferase PF01553.21 ACT01040.1 - 5.1e-26 90.9 0.0 6.6e-26 90.5 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase Lip_A_acyltrans PF03279.13 ACT01040.1 - 0.12 11.6 0.0 0.46 9.6 0.0 2.0 1 1 0 1 1 1 0 Bacterial lipid A biosynthesis acyltransferase S1 PF00575.23 ACT01041.1 - 1.3e-75 249.8 21.4 2.4e-24 85.5 0.1 4.2 4 0 0 4 4 4 4 S1 RNA binding domain S1_2 PF13509.6 ACT01041.1 - 1.3e-05 25.2 0.7 0.72 10.0 0.0 4.4 3 2 0 3 3 3 2 S1 domain RNase_II_C_S1 PF18614.1 ACT01041.1 - 4e-05 23.5 5.2 0.011 15.6 0.0 4.3 4 1 0 4 4 4 1 RNase II-type exonuclease C-terminal S1 domain DUF2110 PF09883.9 ACT01041.1 - 0.00015 21.5 3.0 2.8 7.5 0.2 3.7 1 1 3 4 4 4 3 Uncharacterized protein conserved in archaea (DUF2110) CDC48_2 PF02933.17 ACT01041.1 - 0.00059 19.6 2.3 9.1 6.2 0.0 4.2 3 1 0 3 3 3 1 Cell division protein 48 (CDC48), domain 2 CSD PF00313.22 ACT01041.1 - 0.011 15.6 4.9 0.67 9.9 0.0 4.1 4 0 0 4 4 4 0 'Cold-shock' DNA-binding domain SH3_2 PF07653.17 ACT01041.1 - 0.014 15.1 1.2 4.1 7.2 0.1 3.5 3 0 0 3 3 3 0 Variant SH3 domain YolD PF08863.10 ACT01041.1 - 0.056 13.5 2.2 25 5.0 0.0 4.2 5 0 0 5 5 5 0 YolD-like protein RuvA_N PF01330.21 ACT01041.1 - 0.084 13.0 1.2 3.2 7.9 0.0 3.0 3 0 0 3 3 3 0 RuvA N terminal domain RsgI_N PF12791.7 ACT01041.1 - 0.089 12.7 1.2 2.7 8.0 0.0 3.6 4 0 0 4 4 4 0 Anti-sigma factor N-terminus Rho_RNA_bind PF07497.12 ACT01041.1 - 0.09 12.7 0.1 6.3 6.8 0.0 2.9 3 0 0 3 3 3 0 Rho termination factor, RNA-binding domain A2M_BRD PF07703.14 ACT01041.1 - 0.11 12.8 1.0 2.6 8.4 1.0 3.2 1 1 0 1 1 1 0 Alpha-2-macroglobulin bait region domain CusF_Ec PF11604.8 ACT01041.1 - 0.16 12.0 4.7 21 5.2 0.0 5.0 5 1 0 5 5 5 0 Copper binding periplasmic protein CusF CsrA PF02599.16 ACT01041.1 - 0.81 9.7 4.0 26 4.9 0.1 3.4 3 0 0 3 3 3 0 Global regulator protein family YIEGIA PF14045.6 ACT01043.1 - 8.2e-124 412.0 0.3 9.5e-124 411.8 0.3 1.0 1 0 0 1 1 1 1 YIEGIA protein Voltage_CLC PF00654.20 ACT01043.1 - 0.0016 17.8 4.0 0.003 16.9 4.0 1.4 1 1 0 1 1 1 1 Voltage gated chloride channel DUF2407_C PF13373.6 ACT01043.1 - 0.034 14.3 0.6 0.22 11.7 0.1 2.2 2 0 0 2 2 2 0 DUF2407 C-terminal domain Vezatin PF12632.7 ACT01043.1 - 0.19 11.1 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes Ni_hydr_CYTB PF01292.20 ACT01043.1 - 0.5 9.9 3.3 0.47 10.0 0.6 1.9 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 EFP_N PF08207.12 ACT01044.1 - 0.0087 16.1 0.2 1.8 8.7 0.1 2.1 2 0 0 2 2 2 2 Elongation factor P (EF-P) KOW-like domain MMR_HSR1 PF01926.23 ACT01045.1 - 3.4e-56 188.2 0.4 3.7e-27 94.7 0.1 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.6 ACT01045.1 - 1.7e-35 121.2 0.6 3.2e-35 120.3 0.3 1.7 2 0 0 2 2 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 ACT01045.1 - 3.7e-27 94.8 0.2 1.6e-13 50.4 0.1 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 ACT01045.1 - 1.6e-19 70.2 2.7 5.4e-08 32.6 0.3 5.1 2 2 1 3 3 3 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ACT01045.1 - 4.7e-16 59.3 0.4 0.00089 19.4 0.1 4.5 2 2 2 4 4 4 4 Dynamin family AIG1 PF04548.16 ACT01045.1 - 5e-15 55.4 0.9 3.3e-06 26.6 0.2 3.1 3 1 0 3 3 3 2 AIG1 family RsgA_GTPase PF03193.16 ACT01045.1 - 1e-09 38.5 0.5 0.00088 19.2 0.1 4.2 3 1 0 3 3 3 3 RsgA GTPase Roc PF08477.13 ACT01045.1 - 8.3e-08 32.5 0.6 0.029 14.6 0.0 3.9 2 2 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ACT01045.1 - 2.2e-05 25.0 0.0 0.023 15.2 0.0 2.8 2 1 0 2 2 2 1 ABC transporter PduV-EutP PF10662.9 ACT01045.1 - 0.00011 21.9 0.0 1.4 8.7 0.0 3.6 3 1 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 ACT01045.1 - 0.00019 21.1 4.6 0.002 17.7 0.1 3.3 2 2 2 4 4 4 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 ACT01045.1 - 0.00026 20.9 0.0 0.18 11.8 0.0 2.7 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain Ras PF00071.22 ACT01045.1 - 0.00033 20.3 0.4 0.21 11.2 0.1 2.8 2 2 0 2 2 2 2 Ras family SRPRB PF09439.10 ACT01045.1 - 0.00045 19.7 0.0 1.4 8.4 0.0 2.8 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit TniB PF05621.11 ACT01045.1 - 0.00098 18.6 0.0 1.8 8.0 0.0 2.5 2 1 0 2 2 2 2 Bacterial TniB protein AAA PF00004.29 ACT01045.1 - 0.0022 18.4 0.1 1.2 9.6 0.1 3.3 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Nuc_deoxyri_tr2 PF15891.5 ACT01045.1 - 0.0026 18.1 0.5 1.5 9.2 0.0 2.5 2 0 0 2 2 2 1 Nucleoside 2-deoxyribosyltransferase like AAA_24 PF13479.6 ACT01045.1 - 0.0027 17.4 0.0 1.9 8.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 ACT01045.1 - 0.0034 17.3 0.3 2.4 8.1 0.0 3.3 3 0 0 3 3 3 1 NTPase Guanylate_kin PF00625.21 ACT01045.1 - 0.0044 16.7 0.3 0.16 11.7 0.0 3.2 4 0 0 4 4 4 1 Guanylate kinase Nuc_deoxyrib_tr PF05014.15 ACT01045.1 - 0.005 16.9 0.2 0.3 11.1 0.0 2.4 2 0 0 2 2 2 1 Nucleoside 2-deoxyribosyltransferase MeaB PF03308.16 ACT01045.1 - 0.0061 15.6 0.8 11 4.9 0.0 3.4 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 ACT01045.1 - 0.0085 16.6 0.1 7 7.2 0.0 2.7 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ACT01045.1 - 0.0096 15.1 0.0 1.4 8.0 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_29 PF13555.6 ACT01045.1 - 0.011 15.5 0.0 5 6.9 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 ACT01045.1 - 0.011 16.1 0.0 6.7 7.1 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 ACT01045.1 - 0.039 14.2 0.0 9.6 6.5 0.0 3.1 4 0 0 4 4 3 0 AAA domain AAA_15 PF13175.6 ACT01045.1 - 0.057 13.1 0.0 2.6 7.7 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_16 PF13191.6 ACT01045.1 - 0.067 13.6 0.0 3 8.2 0.0 3.0 3 1 0 3 3 2 0 AAA ATPase domain G3P_acyltransf PF02660.15 ACT01046.1 - 5.4e-53 179.4 17.8 6.2e-53 179.2 17.8 1.0 1 0 0 1 1 1 1 Glycerol-3-phosphate acyltransferase NAD_Gly3P_dh_C PF07479.14 ACT01047.1 - 3.1e-53 179.9 0.1 5.7e-53 179.0 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 ACT01047.1 - 7.2e-53 178.8 0.4 1.2e-52 178.0 0.4 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 ACT01047.1 - 2.3e-06 27.3 0.1 3.7e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 ACT01047.1 - 2.4e-06 28.0 0.8 0.0013 19.3 0.1 3.7 3 1 1 4 4 4 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ACT01047.1 - 2.9e-05 24.3 0.3 0.0001 22.5 0.1 2.1 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 ACT01047.1 - 0.0091 15.9 0.4 0.031 14.2 0.1 2.1 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF4350 PF14258.6 ACT01047.1 - 0.1 13.0 0.2 23 5.5 0.0 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF4350) Semialdhyde_dh PF01118.24 ACT01047.1 - 0.11 13.0 0.4 0.43 11.0 0.1 2.1 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain SpoVIF PF14069.6 ACT01048.1 - 6.7e-22 77.1 4.5 8.3e-22 76.7 4.5 1.1 1 0 0 1 1 1 1 Stage VI sporulation protein F DUF1002 PF06207.11 ACT01048.1 - 0.00012 21.7 3.3 0.00013 21.5 3.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1002) DUF3801 PF12687.7 ACT01048.1 - 0.035 14.2 1.3 0.043 13.9 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) DUF2768 PF10966.8 ACT01049.1 - 6.5e-13 48.9 10.8 7.2e-13 48.8 10.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2768) SUR7 PF06687.12 ACT01049.1 - 1.6 8.3 9.6 1.8 8.2 9.6 1.0 1 0 0 1 1 1 0 SUR7/PalI family DUF5381 PF17353.2 ACT01049.1 - 1.8 8.3 7.1 1.8 8.3 7.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5381) DUF4131 PF13567.6 ACT01049.1 - 2.5 7.7 5.9 2.5 7.7 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF202 PF02656.15 ACT01049.1 - 8.3 6.9 8.0 9.9 6.7 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Fer2 PF00111.27 ACT01050.1 - 4.5e-10 39.4 1.1 5.2e-10 39.1 1.1 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2 PF00111.27 ACT01052.1 - 1e-06 28.6 0.3 1.5e-06 28.0 0.3 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF3939 PF13075.6 ACT01053.1 - 8e-06 25.9 0.6 5.3e-05 23.3 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3939) Spore_IV_A PF09547.10 ACT01054.1 - 5e-226 751.4 0.1 5.6e-226 751.2 0.1 1.0 1 0 0 1 1 1 1 Stage IV sporulation protein A (spore_IV_A) MMR_HSR1 PF01926.23 ACT01054.1 - 0.00065 19.8 0.0 0.0015 18.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ACT01054.1 - 0.0076 15.8 0.0 0.046 13.3 0.0 2.1 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 ACT01054.1 - 0.035 13.1 0.0 0.15 11.0 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Peripla_BP_4 PF13407.6 ACT01055.1 - 1.9e-41 142.4 15.4 2.6e-41 141.9 15.4 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACT01055.1 - 2.2e-12 47.0 1.0 3.9e-12 46.2 1.0 1.4 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 ACT01055.1 - 2.8e-09 37.5 0.0 9.5e-09 35.8 0.0 1.8 2 0 0 2 2 2 1 Periplasmic binding protein-like domain YAcAr PF10686.9 ACT01055.1 - 0.03 14.3 0.1 0.081 12.9 0.0 1.8 2 0 0 2 2 2 0 YspA, cpYpsA-related SLOG family DUF4969 PF16339.5 ACT01055.1 - 0.081 13.3 0.1 2.3 8.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4969) Cadherin_C_2 PF16492.5 ACT01055.1 - 0.096 13.4 0.2 0.23 12.2 0.0 1.7 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal DUF1574 PF07611.11 ACT01055.1 - 0.14 11.5 0.0 0.27 10.5 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1574) Asparaginase_C PF17763.1 ACT01055.1 - 0.5 10.6 2.7 2.6 8.3 0.2 3.1 2 1 2 4 4 4 0 Glutaminase/Asparaginase C-terminal domain ABC_tran PF00005.27 ACT01056.1 - 1.2e-50 171.6 1.4 4.1e-27 95.4 0.1 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACT01056.1 - 7.6e-10 39.1 0.5 0.00046 20.1 0.0 4.0 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ACT01056.1 - 1.1e-06 28.7 0.2 0.0077 16.1 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ACT01056.1 - 1e-05 26.0 0.6 0.022 15.1 0.1 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 ACT01056.1 - 1.5e-05 24.8 3.1 0.017 14.9 0.4 2.8 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 ACT01056.1 - 4.6e-05 24.0 0.0 0.0013 19.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ACT01056.1 - 5.2e-05 23.3 0.3 0.51 10.4 0.0 3.0 3 0 0 3 3 3 2 50S ribosome-binding GTPase SMC_N PF02463.19 ACT01056.1 - 0.00027 20.5 1.1 0.0076 15.7 0.0 2.6 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT01056.1 - 0.00032 20.4 0.2 0.022 14.5 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 ACT01056.1 - 0.0014 19.2 0.6 1.5 9.4 0.1 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ACT01056.1 - 0.0018 18.6 0.4 3.7 7.8 0.0 2.9 2 1 0 2 2 2 2 AAA domain TsaE PF02367.17 ACT01056.1 - 0.0024 17.9 0.3 0.85 9.6 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ACT01056.1 - 0.0031 17.7 0.5 1.5 8.9 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ACT01056.1 - 0.0037 17.3 0.0 9.8 6.2 0.0 3.5 3 1 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 ACT01056.1 - 0.0059 15.9 0.6 1 8.6 0.1 2.2 2 0 0 2 2 2 1 Zeta toxin PduV-EutP PF10662.9 ACT01056.1 - 0.0076 16.0 0.1 0.51 10.1 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 ACT01056.1 - 0.01 15.4 0.3 0.18 11.3 0.1 2.7 3 1 0 3 3 2 0 AAA domain AAA_28 PF13521.6 ACT01056.1 - 0.03 14.5 1.6 0.34 11.2 0.3 2.8 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.22 ACT01056.1 - 0.072 12.7 1.7 8.7 5.9 0.0 3.1 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_27 PF13514.6 ACT01056.1 - 0.073 12.7 0.4 0.37 10.4 0.0 2.2 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 ACT01056.1 - 0.081 12.5 0.6 4 7.0 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_13 PF13166.6 ACT01056.1 - 0.093 11.4 0.1 2 6.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 ACT01056.1 - 0.099 12.9 0.1 13 6.0 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MukB PF04310.12 ACT01056.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 MukB N-terminal ATP-synt_ab PF00006.25 ACT01056.1 - 0.14 11.7 0.1 11 5.6 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF87 PF01935.17 ACT01056.1 - 1 9.4 3.6 2.8 8.0 0.0 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain BPD_transp_2 PF02653.16 ACT01057.1 - 4e-48 163.9 31.7 4e-48 163.9 31.7 1.6 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component LapA_dom PF06305.11 ACT01057.1 - 0.0034 17.2 5.7 0.0034 17.2 5.7 4.4 5 0 0 5 5 5 1 Lipopolysaccharide assembly protein A domain DUF3493 PF11998.8 ACT01057.1 - 0.89 9.8 6.5 0.33 11.2 1.6 2.8 2 0 0 2 2 2 0 Low psii accumulation1 / Rep27 Bac_DNA_binding PF00216.21 ACT01058.1 - 4.8e-36 122.8 0.1 5.4e-36 122.7 0.1 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 ACT01058.1 - 3.3e-07 30.4 0.0 3.7e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_euk_2 PF18289.1 ACT01058.1 - 2.6e-05 24.3 0.1 3.4e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 HU-CCDC81_bac_2 PF18175.1 ACT01058.1 - 7.7e-05 22.5 0.0 0.00011 21.9 0.0 1.2 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 2 DUF2267 PF10025.9 ACT01058.1 - 0.00097 19.4 0.0 0.0014 18.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2267) HU-DNA_bdg PF14848.6 ACT01058.1 - 0.045 13.8 0.0 0.076 13.0 0.0 1.5 1 1 0 1 1 1 0 DNA-binding domain HU-CCDC81_euk_1 PF14908.6 ACT01058.1 - 0.066 13.4 0.0 0.073 13.2 0.0 1.2 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 DUF3235 PF11574.8 ACT01058.1 - 0.095 13.6 0.3 0.16 12.9 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) SIS_2 PF13580.6 ACT01058.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 SIS domain TrpBP PF02081.15 ACT01059.1 - 7.5e-40 134.6 2.5 8.3e-40 134.5 2.5 1.0 1 0 0 1 1 1 1 Tryptophan RNA-binding attenuator protein BAH PF01426.18 ACT01059.1 - 0.095 12.6 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 BAH domain HEPPP_synt_1 PF07307.11 ACT01061.1 - 5.1e-34 117.7 0.4 5.1e-34 117.7 0.4 1.5 2 0 0 2 2 2 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 BBP1_C PF15272.6 ACT01061.1 - 8.1 6.2 10.6 3.4 7.5 1.6 3.0 2 1 0 3 3 3 0 Spindle pole body component BBP1, C-terminal Ubie_methyltran PF01209.18 ACT01062.1 - 2.4e-87 292.1 0.0 2.9e-87 291.9 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ACT01062.1 - 3.8e-23 82.0 0.0 6.1e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT01062.1 - 2.2e-22 79.5 0.0 3.4e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT01062.1 - 1.7e-15 57.1 0.0 2.2e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT01062.1 - 2e-14 53.7 0.0 2.7e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT01062.1 - 1.8e-11 44.7 0.0 2.7e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ACT01062.1 - 4e-05 23.8 0.3 0.00014 22.0 0.3 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase CMAS PF02353.20 ACT01062.1 - 0.00012 21.5 0.1 0.00032 20.1 0.1 1.5 1 1 1 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 ACT01062.1 - 0.00015 21.3 0.1 0.00052 19.5 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_18 PF12847.7 ACT01062.1 - 0.00048 20.1 0.0 0.00069 19.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ACT01062.1 - 0.00071 19.2 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 ACT01062.1 - 0.0013 18.4 0.1 0.0019 17.8 0.1 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 ACT01062.1 - 0.0058 16.5 0.0 0.028 14.3 0.0 1.9 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_24 PF13578.6 ACT01062.1 - 0.01 16.9 0.0 0.021 15.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 ACT01062.1 - 0.063 13.0 0.0 0.37 10.4 0.0 2.3 2 1 0 2 2 2 0 Putative RNA methylase family UPF0020 Methyltransf_3 PF01596.17 ACT01062.1 - 0.063 12.4 0.0 0.089 11.9 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase PCMT PF01135.19 ACT01062.1 - 0.063 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 ACT01062.1 - 0.13 11.9 0.1 0.25 10.9 0.0 1.5 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F NNMT_PNMT_TEMT PF01234.17 ACT01062.1 - 0.18 11.0 0.1 1.2 8.2 0.0 2.1 2 1 0 2 2 2 0 NNMT/PNMT/TEMT family UbiA PF01040.18 ACT01063.1 - 1e-50 172.4 26.8 1.4e-50 172.0 26.8 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Flavoprotein PF02441.19 ACT01064.1 - 9.6e-27 93.7 0.0 1.3e-26 93.3 0.0 1.1 1 0 0 1 1 1 1 Flavoprotein TraT PF05818.12 ACT01064.1 - 0.028 14.1 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein SpoU_sub_bind PF08032.12 ACT01064.1 - 0.11 12.7 0.1 0.32 11.3 0.0 1.8 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding VitK2_biosynth PF02621.14 ACT01065.1 - 3.6e-70 236.5 0.0 4.1e-70 236.3 0.0 1.0 1 0 0 1 1 1 1 Menaquinone biosynthesis polyprenyl_synt PF00348.17 ACT01066.1 - 7.1e-67 225.2 0.0 8.3e-67 224.9 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase NDK PF00334.19 ACT01067.1 - 2.8e-55 186.0 0.0 3.1e-55 185.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DUF1999 PF09390.10 ACT01067.1 - 0.14 11.9 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1999) CheR PF01739.18 ACT01068.1 - 2.7e-57 193.4 0.0 3.5e-57 193.1 0.0 1.1 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.15 ACT01068.1 - 2.9e-17 62.1 1.4 8.9e-17 60.6 0.8 2.1 2 0 0 2 2 2 1 CheR methyltransferase, all-alpha domain Methyltransf_25 PF13649.6 ACT01068.1 - 2.2e-06 28.3 0.0 6.2e-05 23.6 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT01068.1 - 7.1e-06 26.7 0.1 0.00017 22.3 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT01068.1 - 0.00066 19.5 0.1 0.0047 16.7 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT01068.1 - 0.0008 20.0 0.1 0.003 18.2 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain NodS PF05401.11 ACT01068.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_23 PF13489.6 ACT01068.1 - 0.025 14.4 0.0 0.038 13.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF4164 PF13747.6 ACT01068.1 - 0.11 12.8 0.2 0.38 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) UPF0175 PF03683.13 ACT01069.1 - 2.9e-05 23.7 0.0 3.1e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0175) HTH_28 PF13518.6 ACT01069.1 - 0.0085 16.2 0.0 0.01 16.0 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain DHQ_synthase PF01761.20 ACT01070.1 - 2.1e-99 332.0 0.0 2.6e-99 331.7 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 ACT01070.1 - 1.1e-13 51.5 0.4 2.1e-12 47.3 0.0 2.1 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 ACT01070.1 - 1e-12 47.6 2.1 5.5e-12 45.2 0.0 2.3 2 1 0 2 2 2 1 Iron-containing alcohol dehydrogenase CM_1 PF07736.11 ACT01071.1 - 2.1e-48 163.5 0.0 2.4e-48 163.4 0.0 1.0 1 0 0 1 1 1 1 Chorismate mutase type I Chorismate_bind PF00425.18 ACT01072.1 - 3.6e-102 341.3 0.0 5.4e-102 340.8 0.0 1.3 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 ACT01072.1 - 4.3e-42 143.7 0.1 4.7e-41 140.3 0.0 2.3 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Phage_holin_3_1 PF05106.12 ACT01072.1 - 0.15 12.5 0.0 32 5.0 0.0 2.3 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) Glycos_transf_3 PF00591.21 ACT01073.1 - 8.6e-95 317.1 0.9 9.6e-95 317.0 0.2 1.4 2 0 0 2 2 2 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 ACT01073.1 - 5.8e-23 80.5 1.6 8.2e-21 73.6 0.4 3.7 4 0 0 4 4 4 1 Glycosyl transferase family, helical bundle domain IGPS PF00218.21 ACT01074.1 - 4e-93 311.2 0.0 4.5e-93 311.1 0.0 1.0 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase His_biosynth PF00977.21 ACT01074.1 - 0.0044 16.5 0.2 2.8 7.3 0.0 2.2 1 1 0 2 2 2 2 Histidine biosynthesis protein NMO PF03060.15 ACT01074.1 - 0.018 14.4 0.0 0.29 10.5 0.0 2.1 2 0 0 2 2 2 0 Nitronate monooxygenase PRAI PF00697.22 ACT01075.1 - 4.6e-46 157.1 0.0 5.5e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase TMP-TENI PF02581.17 ACT01075.1 - 0.098 12.0 0.0 0.3 10.4 0.0 1.8 2 0 0 2 2 2 0 Thiamine monophosphate synthase PALP PF00291.25 ACT01076.1 - 6.2e-47 160.4 0.4 8.7e-47 159.9 0.4 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Trp_syntA PF00290.20 ACT01077.1 - 3.5e-93 311.2 0.1 4.1e-93 311.0 0.1 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain His_biosynth PF00977.21 ACT01077.1 - 0.00035 20.1 0.0 0.00073 19.1 0.0 1.5 1 0 0 1 1 1 1 Histidine biosynthesis protein BtpA PF03437.15 ACT01077.1 - 0.001 18.5 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 BtpA family PcrB PF01884.17 ACT01077.1 - 0.0021 17.5 0.1 0.0086 15.6 0.0 1.8 1 1 0 2 2 2 1 PcrB family Aminotran_1_2 PF00155.21 ACT01078.1 - 1.4e-59 202.1 0.0 1.6e-59 201.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ACT01078.1 - 2.1e-10 40.1 0.0 3.1e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ACT01078.1 - 4.5e-05 22.2 0.0 7.7e-05 21.4 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.11 ACT01078.1 - 0.0059 15.2 0.0 0.011 14.3 0.0 1.4 1 0 0 1 1 1 1 Methionine gamma-lyase CTP_transf_like PF01467.26 ACT01078.1 - 0.065 13.4 0.0 0.34 11.1 0.0 1.9 2 0 0 2 2 2 0 Cytidylyltransferase-like Alliinase_C PF04864.13 ACT01078.1 - 0.11 11.3 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Allinase DUF1398 PF07166.11 ACT01078.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1398) HTH_Tnp_1 PF01527.20 ACT01078.1 - 0.16 12.3 0.0 6 7.3 0.0 2.8 2 1 0 2 2 2 0 Transposase PDH PF02153.17 ACT01079.1 - 1.9e-70 236.8 0.0 2.4e-70 236.5 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.15 ACT01079.1 - 2.2e-11 44.2 0.0 4.6e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACT01079.1 - 5.9e-09 36.4 0.0 1.7e-08 34.9 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ACT PF01842.25 ACT01079.1 - 3.5e-08 33.1 0.0 3.6e-06 26.6 0.0 2.5 2 0 0 2 2 2 1 ACT domain Rossmann-like PF10727.9 ACT01079.1 - 3.2e-05 23.8 0.0 7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Rossmann-like domain 2-Hacid_dh_C PF02826.19 ACT01079.1 - 9.2e-05 21.9 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ACT01079.1 - 0.00013 22.4 0.1 0.0013 19.1 0.0 2.3 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain ACT_4 PF13291.6 ACT01079.1 - 0.0047 17.5 0.0 0.02 15.5 0.0 2.0 2 0 0 2 2 2 1 ACT domain IlvN PF07991.12 ACT01079.1 - 0.0098 15.5 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_Gly3P_dh_N PF01210.23 ACT01079.1 - 0.01 15.8 0.0 0.17 11.8 0.0 2.2 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 ACT01079.1 - 0.026 14.1 0.2 2.4 7.7 0.1 2.4 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HSM3_N PF18795.1 ACT01079.1 - 0.2 11.1 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 DNA mismatch repair protein HSM3, N terminal domain Sigma70_r2 PF04542.14 ACT01080.1 - 4.4e-18 64.8 0.6 7.1e-18 64.2 0.6 1.3 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT01080.1 - 4.9e-17 61.3 0.2 1.1e-16 60.2 0.2 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT01080.1 - 4.2e-09 35.8 0.1 8.9e-09 34.7 0.1 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACT01080.1 - 0.00095 19.1 1.1 0.0019 18.1 1.1 1.4 1 1 0 1 1 1 1 ECF sigma factor FCD PF07729.12 ACT01080.1 - 0.071 13.5 0.2 1 9.8 0.0 2.5 2 1 1 3 3 3 0 FCD domain PCI PF01399.27 ACT01080.1 - 0.12 12.9 2.4 2.4 8.7 2.4 2.2 1 1 0 1 1 1 0 PCI domain RA PF00788.23 ACT01081.1 - 0.15 12.7 0.3 0.25 12.0 0.3 1.4 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain zf-HC2 PF13490.6 ACT01081.1 - 0.66 10.3 8.3 0.24 11.7 5.2 1.9 2 0 0 2 2 2 0 Putative zinc-finger His_Phos_1 PF00300.22 ACT01082.1 - 1.2e-47 162.1 0.3 1.4e-47 161.9 0.3 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) IDEAL PF08858.10 ACT01084.1 - 6.9e-15 54.5 0.1 8.7e-15 54.2 0.1 1.1 1 0 0 1 1 1 1 IDEAL domain Mistic PF11458.8 ACT01084.1 - 0.11 12.5 0.1 0.12 12.3 0.1 1.1 1 0 0 1 1 1 0 Membrane-integrating protein Mistic DUF2487 PF10673.9 ACT01085.1 - 1.1e-09 38.4 0.0 1.6e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2487) Rieske PF00355.26 ACT01086.1 - 2.9e-12 46.3 0.5 5.6e-12 45.5 0.4 1.5 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain CytB6-F_Fe-S PF08802.10 ACT01086.1 - 1.1e-05 25.4 0.4 1.9e-05 24.6 0.4 1.3 1 0 0 1 1 1 1 Cytochrome B6-F complex Fe-S subunit UCR_Fe-S_N PF10399.9 ACT01086.1 - 0.0032 16.8 0.0 0.0057 16.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal TAT_signal PF10518.9 ACT01086.1 - 0.0058 16.4 0.0 0.0086 15.9 0.0 1.3 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence Rieske_2 PF13806.6 ACT01086.1 - 0.015 15.2 0.0 0.035 14.0 0.0 1.8 1 1 0 1 1 1 0 Rieske-like [2Fe-2S] domain Cytochrome_B PF00033.19 ACT01087.1 - 5.4e-51 173.1 14.5 6.4e-51 172.9 14.5 1.0 1 0 0 1 1 1 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 ACT01087.1 - 4.3e-41 140.7 7.9 4.3e-41 140.7 7.9 1.6 2 0 0 2 2 2 1 Cytochrome b(N-terminal)/b6/petB Ni_hydr_CYTB PF01292.20 ACT01087.1 - 0.00073 19.2 6.7 0.00073 19.2 6.7 2.2 1 1 1 2 2 2 2 Prokaryotic cytochrome b561 Insulin_TMD PF17870.1 ACT01087.1 - 1.9 8.6 7.1 16 5.6 0.0 3.8 3 1 1 4 4 4 0 Insulin receptor trans-membrane segment Cytochrome_CBB3 PF13442.6 ACT01088.1 - 3.2e-13 49.8 0.0 5.7e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 ACT01088.1 - 2.1e-08 35.2 0.2 7.2e-07 30.3 0.1 2.6 1 1 1 2 2 2 1 Cytochrome c Cytochrom_B_C PF00032.17 ACT01088.1 - 6.2e-08 32.9 0.6 1.3e-07 31.9 0.6 1.5 1 0 0 1 1 1 1 Cytochrome b(C-terminal)/b6/petD Haem_bd PF14376.6 ACT01088.1 - 0.12 12.4 0.8 0.84 9.6 0.3 2.2 2 0 0 2 2 2 0 Haem-binding domain DUF1405 PF07187.11 ACT01089.1 - 1.8e-50 171.0 12.6 2.2e-50 170.7 12.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1405) DUF2070 PF09843.9 ACT01089.1 - 1.3 7.2 4.3 1.7 6.9 4.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Spore_YpjB PF09577.10 ACT01090.1 - 1.3e-21 77.5 0.5 1.6e-21 77.2 0.5 1.1 1 0 0 1 1 1 1 Sporulation protein YpjB (SpoYpjB) Chorismate_synt PF01264.21 ACT01090.1 - 0.08 11.6 0.1 0.097 11.4 0.1 1.2 1 0 0 1 1 1 0 Chorismate synthase YitT_membrane PF02588.15 ACT01091.1 - 1.6e-60 204.0 17.1 2.1e-60 203.6 17.1 1.1 1 0 0 1 1 1 1 Uncharacterised 5xTM membrane BCR, YitT family COG1284 DUF2179 PF10035.9 ACT01091.1 - 2e-25 88.3 0.2 1.1e-23 82.7 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2179) MazG PF03819.17 ACT01092.1 - 4.8e-19 68.3 0.0 6.1e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain PRA-PH PF01503.17 ACT01092.1 - 0.035 14.6 0.0 0.042 14.3 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase dUTPase_2 PF08761.11 ACT01092.1 - 0.045 13.9 0.1 0.058 13.6 0.1 1.2 1 0 0 1 1 1 0 dUTPase MazG-like PF12643.7 ACT01092.1 - 0.051 13.8 0.0 0.071 13.4 0.0 1.4 1 0 0 1 1 1 0 MazG-like family TPR_2 PF07719.17 ACT01093.1 - 3e-16 58.2 4.4 0.00014 21.7 0.1 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 ACT01093.1 - 5.2e-13 49.3 2.5 1.1e-05 25.8 0.3 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ACT01093.1 - 6.9e-13 47.8 2.5 0.0012 18.5 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ACT01093.1 - 4.5e-11 42.0 0.7 5.7e-05 23.0 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ACT01093.1 - 1.5e-10 40.5 7.2 3e-05 23.6 0.1 4.1 3 1 1 4 4 4 3 TPR repeat TPR_16 PF13432.6 ACT01093.1 - 2e-10 41.1 7.2 3.3e-07 30.9 0.7 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ACT01093.1 - 5.5e-10 39.3 2.7 0.0001 22.4 0.8 2.7 2 2 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ACT01093.1 - 8.2e-10 38.7 9.9 0.0071 17.1 0.6 4.2 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ACT01093.1 - 1.8e-07 30.7 0.7 2.6 8.3 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ACT01093.1 - 2.1e-07 30.8 0.3 0.00078 19.7 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 ACT01093.1 - 1.6e-06 28.3 8.5 0.051 13.9 1.0 4.2 2 1 2 4 4 4 3 Tetratricopeptide repeat Sel1 PF08238.12 ACT01093.1 - 0.00032 21.3 1.2 0.19 12.5 0.1 4.1 4 0 0 4 4 4 1 Sel1 repeat NPP1 PF05630.11 ACT01093.1 - 0.00064 19.9 0.0 0.00069 19.8 0.0 1.1 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) TOM20_plant PF06552.12 ACT01093.1 - 0.0018 18.0 0.5 1.3 8.8 0.1 2.7 1 1 2 3 3 3 2 Plant specific mitochondrial import receptor subunit TOM20 TPR_10 PF13374.6 ACT01093.1 - 0.0019 18.0 5.4 0.56 10.2 0.3 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ACT01093.1 - 0.0029 17.7 0.7 2.4 8.3 0.1 2.9 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat DUF4919 PF16266.5 ACT01093.1 - 0.0041 17.1 0.2 0.04 13.9 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4919) MIT PF04212.18 ACT01093.1 - 0.053 13.6 2.3 8.2 6.6 0.0 3.8 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ACT01093.1 - 0.33 11.7 6.0 1.1 10.1 0.2 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat DapB_N PF01113.20 ACT01094.1 - 1.7e-36 125.1 0.8 2.5e-36 124.5 0.8 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus DapB_C PF05173.14 ACT01094.1 - 4.8e-29 100.9 0.0 7.6e-29 100.2 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, C-terminus GFO_IDH_MocA PF01408.22 ACT01094.1 - 4.3e-05 24.3 0.3 7.4e-05 23.6 0.3 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 ACT01094.1 - 0.00011 22.7 0.5 0.00018 21.9 0.5 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain CoA_binding PF02629.19 ACT01094.1 - 0.00092 19.9 3.2 0.0027 18.4 3.2 1.7 1 1 0 1 1 1 1 CoA binding domain Sacchrp_dh_NADP PF03435.18 ACT01094.1 - 0.0012 19.1 0.5 0.0034 17.6 0.5 1.8 1 1 1 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_3 PF03447.16 ACT01094.1 - 0.0086 16.7 0.2 0.014 16.1 0.2 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain MGS PF02142.22 ACT01095.1 - 1.5e-16 60.4 0.0 2e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 MGS-like domain PIG-L PF02585.17 ACT01096.1 - 1.4e-21 77.5 0.0 1.9e-21 77.0 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Mon2_C PF16206.5 ACT01096.1 - 0.21 9.7 0.0 0.29 9.2 0.0 1.1 1 0 0 1 1 1 0 C-terminal region of Mon2 protein Glycos_transf_1 PF00534.20 ACT01097.1 - 3e-41 140.8 0.0 5.3e-41 140.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT01097.1 - 3.8e-32 111.5 0.0 6.4e-32 110.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACT01097.1 - 1.5e-22 80.4 0.1 2.4e-22 79.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.6 ACT01097.1 - 3.7e-13 49.7 0.1 6.1e-13 49.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_4_4 PF13579.6 ACT01097.1 - 1.7e-10 41.6 0.0 3.3e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ACT01097.1 - 1.4e-08 35.0 0.0 3.8e-08 33.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 ACT01097.1 - 0.00034 20.4 0.7 0.34 10.6 0.1 2.7 1 1 1 2 2 2 2 Starch synthase catalytic domain PolyA_pol PF01743.20 ACT01098.1 - 1.1e-34 119.5 0.0 2.7e-34 118.3 0.0 1.7 1 0 0 1 1 1 1 Poly A polymerase head domain tRNA_NucTran2_2 PF13735.6 ACT01098.1 - 4.1e-17 62.5 5.3 6.6e-17 61.9 5.3 1.3 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative PolyA_pol_RNAbd PF12627.7 ACT01098.1 - 1.9e-11 43.5 0.1 5.6e-11 42.1 0.1 1.8 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A ORF_2_N PF18492.1 ACT01098.1 - 0.12 12.6 0.2 7.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Open reading frame 2 N-terminal domain BPL_LplA_LipB PF03099.19 ACT01099.1 - 1.8e-18 66.7 0.0 2.8e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family HTH_11 PF08279.12 ACT01099.1 - 4.1e-15 55.4 0.0 1.7e-14 53.5 0.0 2.1 1 0 0 1 1 1 1 HTH domain BPL_LplA_LipB_2 PF16917.5 ACT01099.1 - 1.4e-06 28.0 0.0 4.5e-06 26.3 0.0 1.8 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family HTH_24 PF13412.6 ACT01099.1 - 7.9e-06 25.3 0.0 2.2e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_36 PF13730.6 ACT01099.1 - 0.00011 22.1 0.0 0.00036 20.4 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain Fe_dep_repress PF01325.19 ACT01099.1 - 0.00052 20.1 0.0 0.0017 18.5 0.0 1.8 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain HTH_AsnC-type PF13404.6 ACT01099.1 - 0.0015 18.3 0.0 0.003 17.4 0.0 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain BPL_C PF02237.17 ACT01099.1 - 0.002 18.0 0.0 0.0042 16.9 0.0 1.6 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain MarR_2 PF12802.7 ACT01099.1 - 0.0031 17.4 0.0 0.0074 16.2 0.0 1.6 1 0 0 1 1 1 1 MarR family HTH_1 PF00126.27 ACT01099.1 - 0.0033 17.4 0.3 0.013 15.5 0.0 2.1 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_CodY PF08222.11 ACT01099.1 - 0.034 13.7 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 CodY helix-turn-helix domain Rrf2 PF02082.20 ACT01099.1 - 0.052 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator HTH_Crp_2 PF13545.6 ACT01099.1 - 0.071 13.1 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain TrmB PF01978.19 ACT01099.1 - 0.075 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB GntR PF00392.21 ACT01099.1 - 0.079 12.6 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family MarR PF01047.22 ACT01099.1 - 0.09 12.7 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 MarR family HTH_23 PF13384.6 ACT01099.1 - 0.11 12.3 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain Pantoate_transf PF02548.15 ACT01100.1 - 2.8e-116 387.4 1.2 3.3e-116 387.2 1.2 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 ACT01100.1 - 1.3e-05 24.8 0.7 0.00017 21.1 0.7 2.3 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Asp_Glu_race PF01177.22 ACT01100.1 - 0.0054 16.6 0.2 0.019 14.8 0.1 1.9 1 1 1 2 2 2 1 Asp/Glu/Hydantoin racemase Pantoate_ligase PF02569.15 ACT01101.1 - 7.6e-101 336.8 0.0 8.7e-101 336.6 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Asp_decarbox PF02261.16 ACT01102.1 - 5e-56 187.6 0.5 5.7e-56 187.4 0.5 1.0 1 0 0 1 1 1 1 Aspartate decarboxylase TPR_2 PF07719.17 ACT01103.1 - 1.5e-09 37.2 0.4 0.029 14.5 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ACT01103.1 - 1.2e-06 28.0 1.4 0.12 12.3 0.4 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ACT01103.1 - 3.9e-05 23.8 1.1 0.00023 21.4 0.6 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ACT01103.1 - 0.0029 18.1 0.0 0.011 16.2 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ACT01103.1 - 0.0084 16.7 0.3 0.17 12.6 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ACT01103.1 - 0.022 15.4 0.2 0.97 10.2 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ExsD PF16806.5 ACT01103.1 - 0.037 13.9 0.1 0.075 12.9 0.1 1.4 1 0 0 1 1 1 0 Antiactivator protein ExsD LTXXQ PF07813.12 ACT01103.1 - 0.043 14.5 1.6 0.043 14.5 1.6 2.2 2 0 0 2 2 2 0 LTXXQ motif family protein TPR_14 PF13428.6 ACT01103.1 - 0.056 14.3 0.3 6.9 7.8 0.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ACT01103.1 - 0.081 13.0 0.3 2.5 8.4 0.1 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat Helicase_C_2 PF13307.6 ACT01104.1 - 1.1e-36 126.6 0.0 1.9e-36 125.8 0.0 1.4 1 0 0 1 1 1 1 Helicase C-terminal domain RNase_T PF00929.24 ACT01104.1 - 7.4e-30 104.7 0.0 1.6e-29 103.6 0.0 1.6 1 0 0 1 1 1 1 Exonuclease DEAD PF00270.29 ACT01104.1 - 5.5e-09 36.0 0.1 0.0012 18.7 0.0 4.2 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.15 ACT01104.1 - 9.8e-09 35.4 0.1 5.9e-08 32.9 0.1 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF5051 PF16473.5 ACT01104.1 - 0.00031 20.8 0.0 0.00099 19.1 0.0 1.9 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like Helicase_C PF00271.31 ACT01104.1 - 0.00085 19.6 0.0 0.0033 17.8 0.0 2.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD_2 PF06733.15 ACT01104.1 - 0.0021 17.7 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 T4SS-DNA_transf PF02534.14 ACT01104.1 - 0.038 12.8 0.0 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer CoA_binding PF02629.19 ACT01105.1 - 1e-22 80.6 0.5 1.6e-22 80.0 0.5 1.3 1 0 0 1 1 1 1 CoA binding domain Put_DNA-bind_N PF06971.13 ACT01105.1 - 1.9e-19 69.4 0.3 3.6e-19 68.5 0.3 1.5 1 0 0 1 1 1 1 Putative DNA-binding protein N-terminus GFO_IDH_MocA PF01408.22 ACT01105.1 - 2.3e-08 34.9 0.1 3.4e-08 34.3 0.1 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GARS_N PF02844.15 ACT01105.1 - 0.0036 18.1 0.2 0.006 17.3 0.2 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain NAD_binding_2 PF03446.15 ACT01105.1 - 0.025 14.8 0.1 0.036 14.3 0.1 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase PglD_N PF17836.1 ACT01105.1 - 0.027 15.1 0.3 0.055 14.1 0.3 1.5 1 0 0 1 1 1 0 PglD N-terminal domain F420_oxidored PF03807.17 ACT01105.1 - 0.03 14.9 0.1 0.082 13.5 0.1 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent CoA_binding_3 PF13727.6 ACT01105.1 - 0.043 13.8 0.1 0.066 13.2 0.1 1.2 1 0 0 1 1 1 0 CoA-binding domain ELFV_dehydrog PF00208.21 ACT01105.1 - 0.052 13.3 0.1 0.069 12.9 0.1 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GCV_T PF01571.21 ACT01105.1 - 0.059 12.7 0.0 0.075 12.4 0.0 1.2 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain Shikimate_DH PF01488.20 ACT01105.1 - 0.087 12.9 0.2 0.14 12.2 0.2 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CutC PF03932.14 ACT01105.1 - 0.11 11.9 0.2 0.2 11.1 0.2 1.3 1 0 0 1 1 1 0 CutC family Amidohydro_1 PF01979.20 ACT01106.1 - 1.3e-69 235.1 0.1 1.6e-69 234.9 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ACT01106.1 - 1.1e-17 64.7 2.1 2.2e-17 63.7 2.1 1.4 1 1 0 1 1 1 1 Amidohydrolase family A_deaminase PF00962.22 ACT01106.1 - 0.06 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Adenosine/AMP deaminase DUF5590 PF17881.1 ACT01107.1 - 3.2e-09 36.7 0.7 3.2e-09 36.7 0.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF5590) PepSY PF03413.19 ACT01107.1 - 0.0034 17.9 0.9 0.0095 16.5 0.2 2.0 2 0 0 2 2 2 1 Peptidase propeptide and YPEB domain Cation_ATPase_C PF00689.21 ACT01107.1 - 0.05 13.3 0.0 0.052 13.2 0.0 1.2 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus NnrU PF07298.11 ACT01107.1 - 0.068 12.7 0.2 0.09 12.3 0.2 1.4 1 0 0 1 1 1 0 NnrU protein Ras_bdg_2 PF14847.6 ACT01107.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Ras-binding domain of Byr2 DUF2681 PF10883.8 ACT01107.1 - 1.5 9.3 5.6 2.5 8.6 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) Glyco_hydro_49N PF17433.2 ACT01108.1 - 0.0085 15.7 0.2 0.012 15.3 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 49 N-terminal Ig-like domain Pox_A28 PF04584.14 ACT01108.1 - 0.015 15.5 0.0 0.039 14.2 0.0 1.7 1 1 0 2 2 2 0 Poxvirus A28 family Phage_sheath_1N PF17481.2 ACT01108.1 - 0.015 15.8 0.7 0.023 15.2 0.6 1.5 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain DUF1687 PF07955.11 ACT01108.1 - 0.036 14.5 0.3 0.17 12.4 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1687) Carbpep_Y_N PF05388.11 ACT01108.1 - 0.092 13.3 0.1 0.14 12.7 0.1 1.3 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide HU-CCDC81_euk_1 PF14908.6 ACT01108.1 - 0.16 12.1 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 AAA PF00004.29 ACT01109.1 - 5.5e-40 136.9 0.0 1.4e-39 135.6 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Peptidase_M41 PF01434.18 ACT01109.1 - 1.1e-29 103.6 0.5 3.3e-26 92.3 0.1 2.4 1 1 1 2 2 2 2 Peptidase family M41 AAA_lid_3 PF17862.1 ACT01109.1 - 7.7e-09 35.2 0.1 1.9e-08 34.0 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ACT01109.1 - 5e-06 27.0 0.1 6e-05 23.5 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ACT01109.1 - 1.3e-05 25.2 0.1 5.7e-05 23.1 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ACT01109.1 - 2.6e-05 24.5 0.5 0.00099 19.4 0.3 2.7 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ACT01109.1 - 0.00025 21.2 0.1 0.00093 19.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_30 PF13604.6 ACT01109.1 - 0.00041 20.1 0.1 0.0012 18.6 0.1 1.8 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ACT01109.1 - 0.00059 19.6 0.6 0.016 15.0 0.6 2.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 ACT01109.1 - 0.0014 17.9 0.0 0.0052 16.0 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 ACT01109.1 - 0.0015 18.9 0.0 0.0034 17.8 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 ACT01109.1 - 0.0029 17.6 0.0 0.0076 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ACT01109.1 - 0.0046 16.3 0.1 0.0046 16.3 0.1 2.9 3 1 0 4 4 4 1 KaiC AAA_7 PF12775.7 ACT01109.1 - 0.0047 16.5 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 ACT01109.1 - 0.0054 16.5 0.0 0.013 15.2 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 ACT01109.1 - 0.0063 15.9 0.0 0.016 14.6 0.0 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ACT01109.1 - 0.0073 16.9 0.2 0.036 14.6 0.1 2.2 2 1 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 ACT01109.1 - 0.01 15.7 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein T2SSE PF00437.20 ACT01109.1 - 0.015 14.4 0.2 0.062 12.3 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein NTPase_1 PF03266.15 ACT01109.1 - 0.025 14.5 0.3 0.74 9.7 0.1 2.5 1 1 1 2 2 2 0 NTPase TIP49 PF06068.13 ACT01109.1 - 0.029 13.6 0.0 0.08 12.1 0.0 1.7 1 0 0 1 1 1 0 TIP49 P-loop domain Parvo_NS1 PF01057.17 ACT01109.1 - 0.03 13.4 0.1 0.16 11.0 0.0 1.9 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 ACT01109.1 - 0.038 13.7 0.1 0.1 12.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ACT01109.1 - 0.05 13.3 0.1 0.28 10.9 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.16 ACT01109.1 - 0.06 12.8 0.1 0.23 10.9 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.6 ACT01109.1 - 0.072 13.3 2.3 0.1 12.8 0.1 2.4 3 1 0 3 3 2 0 AAA domain AAA_17 PF13207.6 ACT01109.1 - 0.1 13.0 0.0 0.1 13.0 0.0 2.2 3 0 0 3 3 2 0 AAA domain DUF2075 PF09848.9 ACT01109.1 - 0.12 11.6 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 ACT01109.1 - 0.14 12.5 3.7 0.41 11.0 0.3 3.1 2 2 0 2 2 2 0 AAA domain 3HCDH_N PF02737.18 ACT01110.1 - 7e-57 192.2 0.6 8.8e-57 191.9 0.6 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ACT01110.1 - 2.5e-27 95.3 0.1 5.9e-27 94.1 0.1 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ACT01110.1 - 9.3e-06 25.9 2.6 0.0001 22.5 1.7 2.6 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACT01110.1 - 1.4e-05 25.5 0.4 4.1e-05 24.1 0.4 1.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_2 PF07992.14 ACT01110.1 - 0.00013 21.3 0.1 0.00016 21.1 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 ACT01110.1 - 0.00032 20.4 0.1 0.0006 19.5 0.1 1.6 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 ACT01110.1 - 0.0013 18.1 0.2 0.0021 17.4 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 ACT01110.1 - 0.0014 18.6 0.6 0.0065 16.5 0.6 2.2 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.18 ACT01110.1 - 0.0015 18.8 0.7 0.0048 17.1 0.1 2.0 2 0 0 2 2 2 1 TrkA-N domain Pyr_redox PF00070.27 ACT01110.1 - 0.0017 18.8 2.2 0.0043 17.6 0.8 2.5 2 1 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 ACT01110.1 - 0.0023 18.2 0.0 0.037 14.3 0.0 2.3 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ACT01110.1 - 0.0027 17.8 0.4 0.0027 17.8 0.4 2.1 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 ACT01110.1 - 0.0071 15.9 2.5 0.11 12.1 2.1 2.4 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 ACT01110.1 - 0.022 14.0 0.2 0.036 13.3 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain DFP PF04127.15 ACT01110.1 - 0.033 14.0 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein adh_short PF00106.25 ACT01110.1 - 0.036 13.5 0.0 0.076 12.5 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase NAD_binding_7 PF13241.6 ACT01110.1 - 0.06 13.8 0.1 0.1 13.0 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 ACT01110.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 ACT01110.1 - 0.18 11.3 0.1 0.79 9.2 0.1 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase DapB_N PF01113.20 ACT01110.1 - 0.37 10.9 2.0 0.5 10.5 0.9 1.9 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Acetate_kinase PF00871.17 ACT01111.1 - 4.8e-156 519.4 2.3 5.5e-156 519.2 2.3 1.0 1 0 0 1 1 1 1 Acetokinase family DnaB_2 PF07261.11 ACT01112.1 - 1.1e-24 85.9 0.0 5.1e-24 83.8 0.0 2.0 2 0 0 2 2 2 1 Replication initiation and membrane attachment HTH_36 PF13730.6 ACT01112.1 - 4e-08 33.1 0.0 8.5e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT01112.1 - 0.00083 19.3 0.2 0.0019 18.2 0.2 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HemN_C PF06969.16 ACT01112.1 - 0.0031 17.5 1.6 0.0059 16.6 0.7 2.0 2 0 0 2 2 2 1 HemN C-terminal domain HTH_24 PF13412.6 ACT01112.1 - 0.037 13.6 0.0 0.065 12.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Herpes_UL56 PF04534.12 ACT01112.1 - 0.063 12.8 0.1 0.091 12.2 0.1 1.2 1 0 0 1 1 1 0 Herpesvirus UL56 protein TrmB PF01978.19 ACT01112.1 - 0.076 12.9 0.0 0.19 11.6 0.0 1.6 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_18 PF12833.7 ACT01113.1 - 1.5e-19 70.0 0.0 2.4e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01113.1 - 5.5e-17 61.4 0.2 9.6e-09 35.1 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT01113.1 - 0.00031 20.7 2.9 0.0017 18.2 2.9 2.2 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT01113.1 - 0.0089 15.7 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Glyco_hydro_127 PF07944.12 ACT01114.1 - 6.9e-174 579.2 1.4 7.9e-174 579.0 1.4 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_76 PF03663.14 ACT01114.1 - 1.1e-05 25.1 3.5 0.00072 19.2 0.1 3.0 4 0 0 4 4 4 2 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 ACT01114.1 - 0.0028 16.8 0.2 0.014 14.5 0.2 2.0 1 1 1 2 2 2 1 Glycosyl Hydrolase Family 88 GlcNAc_2-epim PF07221.11 ACT01114.1 - 0.03 13.6 1.7 1.4 8.1 0.1 3.2 2 1 1 3 3 3 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) AIM24 PF01987.17 ACT01115.1 - 1.8e-67 227.1 0.1 2.1e-67 226.8 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 DUF1572 PF07609.11 ACT01116.1 - 1.4e-25 90.0 0.4 1.7e-25 89.7 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1572) DinB_2 PF12867.7 ACT01116.1 - 4e-09 37.0 0.0 5.2e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 DinB superfamily DinB PF05163.12 ACT01116.1 - 1.7e-05 24.8 0.3 3.3e-05 23.9 0.3 1.5 1 1 0 1 1 1 1 DinB family DUF664 PF04978.12 ACT01116.1 - 0.00018 22.0 0.1 0.00041 20.8 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF664) Pribosyltran PF00156.27 ACT01117.1 - 1.3e-13 50.7 0.2 1.7e-13 50.4 0.2 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Aldolase_II PF00596.21 ACT01118.1 - 6.4e-35 120.8 0.0 7.4e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Utp11 PF03998.13 ACT01118.1 - 0.047 13.6 0.0 0.075 13.0 0.0 1.3 1 0 0 1 1 1 0 Utp11 protein HAD PF12710.7 ACT01119.1 - 8.7e-16 58.9 0.0 1.2e-15 58.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 ACT01119.1 - 2.6e-08 33.5 0.1 3.2e-08 33.3 0.1 1.1 1 0 0 1 1 1 1 Putative Phosphatase HAD_2 PF13419.6 ACT01119.1 - 0.00017 21.7 0.1 0.84 9.7 0.0 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT01119.1 - 0.00052 20.4 0.0 0.17 12.2 0.0 2.6 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ACT01119.1 - 0.0062 16.3 0.0 0.12 12.1 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 ACT01119.1 - 0.03 13.8 0.0 1.3 8.5 0.0 2.3 1 1 1 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) RuBisCO_large PF00016.20 ACT01120.1 - 7.3e-51 173.1 0.0 1.6e-49 168.7 0.0 2.0 1 1 0 1 1 1 1 Ribulose bisphosphate carboxylase large chain, catalytic domain RuBisCO_large_N PF02788.16 ACT01120.1 - 9.5e-05 22.6 0.0 0.00016 21.8 0.0 1.4 1 0 0 1 1 1 1 Ribulose bisphosphate carboxylase large chain, N-terminal domain DNA_pol3_gamma3 PF12169.8 ACT01120.1 - 0.008 16.1 0.0 0.057 13.3 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase III subunits gamma and tau domain III P5CR_dimer PF14748.6 ACT01121.1 - 7.5e-33 112.9 3.9 1.1e-32 112.3 2.8 1.9 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 ACT01121.1 - 2.7e-19 69.5 1.3 5.4e-19 68.6 0.2 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 ACT01121.1 - 6.2e-08 32.8 1.0 1.2e-07 31.8 0.4 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 ACT01121.1 - 4e-05 23.3 0.1 7.1e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 ACT01121.1 - 0.0042 17.3 0.7 0.01 16.0 0.2 1.9 1 1 1 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Diphthami_syn_2 PF01902.17 ACT01121.1 - 0.021 14.4 0.0 0.11 11.9 0.0 2.1 2 0 0 2 2 2 0 Diphthamide synthase PTS_IIB PF02302.17 ACT01121.1 - 0.064 14.0 0.6 18 6.1 0.0 2.6 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIB subunit Aldedh PF00171.22 ACT01122.1 - 1.3e-17 63.5 6.8 5.9e-14 51.4 3.0 2.2 1 1 1 2 2 2 2 Aldehyde dehydrogenase family AA_kinase PF00696.28 ACT01123.1 - 2.4e-47 161.6 1.1 3.4e-47 161.1 1.1 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 ACT01123.1 - 2.9e-19 68.8 1.4 4.9e-19 68.1 0.2 2.1 2 0 0 2 2 2 1 PUA domain PUA_3 PF17785.1 ACT01123.1 - 0.0017 18.1 0.0 0.0042 16.9 0.0 1.7 1 0 0 1 1 1 1 PUA-like domain UPF0113 PF03657.13 ACT01123.1 - 0.031 14.5 0.0 0.068 13.4 0.0 1.6 1 0 0 1 1 1 0 UPF0113 PUA domain Aminotran_1_2 PF00155.21 ACT01124.1 - 1.3e-61 208.8 0.0 1.5e-61 208.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II 2-Hacid_dh PF00389.30 ACT01124.1 - 0.0074 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain CUB_2 PF02408.20 ACT01125.1 - 0.047 13.4 0.0 0.061 13.1 0.0 1.1 1 0 0 1 1 1 0 CUB-like domain DnaA_N PF11638.8 ACT01125.1 - 0.16 11.8 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 DnaA N-terminal domain TrbC PF04956.13 ACT01125.1 - 0.24 11.7 1.1 1.1 9.5 1.1 1.9 1 1 0 1 1 1 0 TrbC/VIRB2 family CN_hydrolase PF00795.22 ACT01126.1 - 2.3e-59 200.8 0.0 2.6e-59 200.7 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase EndoU_bacteria PF14436.6 ACT01126.1 - 0.085 13.2 0.0 0.18 12.1 0.0 1.5 1 1 0 1 1 1 0 Bacterial EndoU nuclease LysR_substrate PF03466.20 ACT01127.1 - 2.9e-51 173.8 0.0 3.6e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01127.1 - 1.6e-21 76.0 1.1 4.5e-21 74.6 1.1 1.8 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 ACT01127.1 - 0.011 15.5 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_5 PF01022.20 ACT01127.1 - 0.024 14.5 0.1 0.063 13.2 0.1 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family DDE_Tnp_IS240 PF13610.6 ACT01127.1 - 0.06 13.6 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 DDE domain WXG100 PF06013.12 ACT01127.1 - 1.6 9.1 4.1 1.3 9.3 0.7 2.3 3 0 0 3 3 3 0 Proteins of 100 residues with WXG Aconitase PF00330.20 ACT01128.1 - 5.3e-161 536.7 0.0 6e-161 536.5 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ACT01129.1 - 1.5e-36 125.6 0.0 2e-36 125.2 0.0 1.2 1 0 0 1 1 1 1 Aconitase C-terminal domain Amidase_3 PF01520.18 ACT01130.1 - 1.1e-52 178.7 0.3 1.1e-52 178.7 0.3 1.5 2 0 0 2 2 2 1 N-acetylmuramoyl-L-alanine amidase Cu_amine_oxidN1 PF07833.11 ACT01130.1 - 1.7e-29 102.1 2.2 4.5e-29 100.8 2.2 1.8 1 0 0 1 1 1 1 Copper amine oxidase N-terminal domain AMIN PF11741.8 ACT01130.1 - 9.7e-10 38.5 1.8 1.3e-09 38.0 0.2 2.1 2 0 0 2 2 2 1 AMIN domain Germane PF10646.9 ACT01131.1 - 6.4e-11 43.0 0.1 8.6e-11 42.5 0.1 1.2 1 0 0 1 1 1 1 Sporulation and spore germination DUF4277 PF14104.6 ACT01131.1 - 0.017 15.5 0.0 0.035 14.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4277) SLH PF00395.20 ACT01132.1 - 8.3e-13 48.1 3.1 7e-06 25.9 0.0 4.4 5 0 0 5 5 5 2 S-layer homology domain HisG_C PF08029.11 ACT01132.1 - 0.091 12.9 0.1 12 6.1 0.0 2.8 2 0 0 2 2 2 0 HisG, C-terminal domain HhH-GPD PF00730.25 ACT01133.1 - 1.8e-24 86.3 0.0 2.5e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ACT01133.1 - 3.1e-08 33.1 0.0 6.3e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 ACT01133.1 - 0.00021 21.6 5.9 0.00054 20.2 5.9 1.8 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III HHH_8 PF14716.6 ACT01133.1 - 0.012 15.9 0.0 0.043 14.2 0.0 2.0 1 1 0 1 1 1 0 Helix-hairpin-helix domain HHH_5 PF14520.6 ACT01133.1 - 0.047 14.3 0.0 0.1 13.2 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain ProQ PF04352.13 ACT01133.1 - 0.14 12.1 0.0 0.8 9.6 0.0 2.0 2 0 0 2 2 2 0 ProQ/FINO family DAP PF15228.6 ACT01134.1 - 0.16 13.1 0.0 0.19 12.9 0.0 1.1 1 0 0 1 1 1 0 Death-associated protein Dynamin_N PF00350.23 ACT01135.1 - 1.2e-69 233.6 0.0 1e-37 129.8 0.0 2.9 2 1 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.23 ACT01135.1 - 1.1e-20 73.8 0.0 7e-10 39.0 0.0 3.8 2 1 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ACT01135.1 - 4e-08 33.0 0.0 2.6e-05 23.9 0.0 3.2 3 1 0 3 3 3 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ACT01135.1 - 7.5e-08 32.5 0.1 0.0024 17.8 0.1 4.1 4 1 0 4 4 4 2 RsgA GTPase FeoB_N PF02421.18 ACT01135.1 - 3.3e-06 26.7 0.4 0.5 9.9 0.0 3.9 4 0 0 4 4 4 2 Ferrous iron transport protein B AIG1 PF04548.16 ACT01135.1 - 0.0014 18.0 0.2 0.73 9.1 0.0 3.2 4 0 0 4 4 4 2 AIG1 family ABC_tran PF00005.27 ACT01135.1 - 0.0068 16.9 0.1 3.9 8.0 0.0 3.0 2 0 0 2 2 2 1 ABC transporter TsaE PF02367.17 ACT01135.1 - 0.022 14.7 0.0 5.1 7.1 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Septin PF00735.18 ACT01135.1 - 0.023 14.0 0.0 0.58 9.4 0.0 2.3 2 0 0 2 2 2 0 Septin AAA_28 PF13521.6 ACT01135.1 - 0.28 11.4 5.5 3 8.1 0.0 3.9 4 0 0 4 4 4 0 AAA domain RGI_lyase PF18370.1 ACT01137.1 - 1e-29 102.7 0.1 2.2e-29 101.6 0.1 1.6 1 0 0 1 1 1 1 Rhamnogalacturonan I lyases beta-sheet domain FG-GAP PF01839.23 ACT01137.1 - 1.9e-10 40.7 2.9 0.0025 17.9 0.2 4.1 3 0 0 3 3 3 3 FG-GAP repeat VCBS PF13517.6 ACT01137.1 - 1.6e-09 38.2 5.8 0.013 16.1 0.2 5.4 5 0 0 5 5 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 ACT01137.1 - 7.5e-05 22.2 2.4 1.3 8.4 0.1 3.9 2 1 0 3 3 3 3 Insecticide toxin TcdB middle/N-terminal region BBS2_Mid PF14783.6 ACT01137.1 - 0.044 13.8 0.0 31 4.7 0.0 3.4 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region DDE_Tnp_1_6 PF13751.6 ACT01138.1 - 8e-31 106.9 0.6 2.2e-30 105.4 0.6 1.8 1 0 0 1 1 1 1 Transposase DDE domain DUF772 PF05598.11 ACT01138.1 - 1.5e-19 69.8 0.3 8e-19 67.4 0.3 2.2 2 0 0 2 2 2 1 Transposase domain (DUF772) DDE_Tnp_1 PF01609.21 ACT01138.1 - 7.2e-18 65.0 0.5 2e-17 63.6 0.5 1.8 1 1 0 1 1 1 1 Transposase DDE domain DUF1664 PF07889.12 ACT01138.1 - 0.38 10.8 2.6 0.54 10.3 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) MFS_1 PF07690.16 ACT01140.1 - 1.2e-22 80.4 41.7 1.2e-22 80.4 41.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 ACT01140.1 - 3e-11 42.4 22.3 5.5e-11 41.6 22.3 1.3 1 1 0 1 1 1 1 Transmembrane secretion effector TetR_C_17 PF17922.1 ACT01141.1 - 9.2e-30 102.7 0.0 1.6e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 ACT01141.1 - 4e-17 61.7 0.2 4e-17 61.7 0.2 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family HTH_23 PF13384.6 ACT01141.1 - 0.0062 16.3 0.3 0.094 12.5 0.0 2.8 3 1 1 4 4 4 1 Homeodomain-like domain TetR_C_5 PF08360.11 ACT01141.1 - 0.053 13.7 0.1 0.37 11.0 0.0 2.0 1 1 1 2 2 2 0 QacR-like protein, C-terminal region DUF4519 PF15012.6 ACT01141.1 - 0.19 11.9 1.3 0.21 11.8 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) ADH_zinc_N PF00107.26 ACT01142.1 - 6.1e-27 94.2 0.2 9.8e-27 93.5 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ACT01142.1 - 1.7e-19 71.2 0.3 4.1e-19 70.0 0.2 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ACT01142.1 - 8.3e-09 35.3 2.1 5.6e-08 32.6 0.0 2.9 3 1 1 4 4 4 1 Alcohol dehydrogenase GroES-like domain MLTR_LBD PF17765.1 ACT01143.1 - 7e-37 127.1 0.0 1.1e-36 126.5 0.0 1.2 1 0 0 1 1 1 1 MmyB-like transcription regulator ligand binding domain HTH_31 PF13560.6 ACT01143.1 - 2e-19 69.7 0.3 4.2e-19 68.6 0.2 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain PAS PF00989.25 ACT01143.1 - 0.0056 16.7 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 PAS fold HTH_19 PF12844.7 ACT01143.1 - 0.01 15.8 0.0 0.023 14.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_3 PF01381.22 ACT01143.1 - 0.079 13.0 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix ABC_membrane PF00664.23 ACT01144.1 - 3e-57 194.3 8.3 4e-57 194.0 8.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT01144.1 - 3.4e-32 111.8 0.0 5.9e-32 111.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT01144.1 - 0.0021 17.5 0.3 0.078 12.4 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACT01144.1 - 0.0058 17.0 0.0 0.013 15.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain FtsK_SpoIIIE PF01580.18 ACT01144.1 - 0.0075 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_29 PF13555.6 ACT01144.1 - 0.025 14.3 0.0 0.06 13.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.13 ACT01144.1 - 0.033 13.4 0.0 0.068 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) MeaB PF03308.16 ACT01144.1 - 0.033 13.2 0.0 0.057 12.4 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 ACT01144.1 - 0.043 13.9 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 ACT01144.1 - 0.057 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 ACT01144.1 - 0.074 13.5 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACT01144.1 - 0.11 12.6 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_5 PF07728.14 ACT01144.1 - 0.12 12.4 0.4 0.8 9.7 0.1 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 ACT01144.1 - 0.13 11.5 0.0 0.47 9.7 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin NB-ARC PF00931.22 ACT01144.1 - 0.19 10.9 0.0 1.5 7.9 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain ABC_membrane PF00664.23 ACT01145.1 - 4.2e-42 144.7 10.0 6e-42 144.2 10.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT01145.1 - 4.4e-33 114.7 0.0 1e-32 113.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 ACT01145.1 - 4.4e-05 23.8 0.3 0.00062 20.0 0.3 2.4 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 ACT01145.1 - 9e-05 22.0 0.7 0.024 14.1 0.0 2.3 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 ACT01145.1 - 0.00046 19.5 0.0 0.0011 18.3 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 ACT01145.1 - 0.0006 20.2 0.1 0.0021 18.5 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 ACT01145.1 - 0.0013 18.6 0.8 1.5 8.6 0.1 2.6 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 ACT01145.1 - 0.0016 18.9 0.0 0.056 13.9 0.0 2.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ACT01145.1 - 0.0016 18.5 0.0 0.004 17.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ACT01145.1 - 0.0017 18.0 0.2 0.0051 16.5 0.2 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT01145.1 - 0.0027 17.6 0.0 0.0064 16.4 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 ACT01145.1 - 0.0033 18.0 0.1 0.018 15.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ACT01145.1 - 0.015 14.8 0.0 0.078 12.5 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF87 PF01935.17 ACT01145.1 - 0.032 14.3 0.1 0.032 14.3 0.1 2.2 3 0 0 3 3 3 0 Helicase HerA, central domain Dynamin_N PF00350.23 ACT01145.1 - 0.066 13.3 0.1 0.2 11.7 0.0 1.8 2 0 0 2 2 2 0 Dynamin family T2SSE PF00437.20 ACT01145.1 - 0.075 12.1 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_membrane_3 PF13748.6 ACT01145.1 - 0.081 12.2 7.5 0.41 9.9 7.5 1.9 1 1 0 1 1 1 0 ABC transporter transmembrane region FAST_2 PF08368.12 ACT01145.1 - 0.087 13.6 0.0 0.22 12.4 0.0 1.7 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 2 G-alpha PF00503.20 ACT01145.1 - 0.099 11.8 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit AAA_15 PF13175.6 ACT01145.1 - 0.12 12.1 0.4 0.28 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain ATP-grasp PF02222.22 ACT01146.1 - 8e-59 198.1 0.0 1.2e-58 197.4 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ACT01146.1 - 1.7e-07 31.0 0.0 8.9e-07 28.6 0.0 1.9 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.17 ACT01146.1 - 1.8e-07 30.9 0.0 3e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain RimK PF08443.11 ACT01146.1 - 1.5e-06 28.0 0.0 2.4e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GARS_A PF01071.19 ACT01146.1 - 1.6e-05 24.8 0.0 2.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Epimerase PF01370.21 ACT01146.1 - 8.4e-05 22.1 0.0 0.00014 21.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 ACT01146.1 - 0.00047 19.6 0.0 0.00075 18.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ATPgrasp_ST PF14397.6 ACT01146.1 - 0.0041 16.4 0.0 0.093 12.0 0.0 2.7 2 1 0 2 2 2 1 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 ACT01146.1 - 0.006 16.6 0.0 0.018 15.1 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain RmlD_sub_bind PF04321.17 ACT01146.1 - 0.0095 15.1 0.0 0.019 14.1 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain ATP-grasp_5 PF13549.6 ACT01146.1 - 0.015 14.8 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_N PF18130.1 ACT01146.1 - 0.16 12.6 2.4 0.55 10.8 0.1 2.8 3 0 0 3 3 3 0 ATP-grasp N-terminal domain DNA_gyraseB PF00204.25 ACT01147.1 - 9.8e-59 197.7 2.3 2.3e-58 196.5 2.3 1.7 1 0 0 1 1 1 1 DNA gyrase B DNA_gyraseB_C PF00986.21 ACT01147.1 - 1.2e-30 105.4 0.1 5.2e-30 103.4 0.2 2.1 2 0 0 2 2 2 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 ACT01147.1 - 1.2e-20 74.1 0.4 2.9e-20 72.8 0.2 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 ACT01147.1 - 2.6e-18 66.1 0.0 6.4e-18 64.9 0.0 1.7 1 0 0 1 1 1 1 Toprim domain HATPase_c_3 PF13589.6 ACT01147.1 - 0.00019 21.3 0.0 0.00062 19.6 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MHB PF16525.5 ACT01147.1 - 0.016 15.4 0.3 0.07 13.4 0.3 2.0 2 0 0 2 2 2 0 Haemophore, haem-binding Ish1 PF10281.9 ACT01147.1 - 0.017 15.4 0.0 0.06 13.7 0.0 2.0 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein VWA PF00092.28 ACT01147.1 - 0.028 14.7 0.1 0.092 13.0 0.0 1.9 2 0 0 2 2 2 0 von Willebrand factor type A domain Arm-DNA-bind_3 PF13356.6 ACT01147.1 - 9.5 6.7 6.3 2.9 8.3 0.7 2.5 2 1 0 2 2 2 0 Arm DNA-binding domain DNA_topoisoIV PF00521.20 ACT01148.1 - 2e-153 511.3 1.9 2.9e-153 510.8 1.9 1.2 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 ACT01148.1 - 4.9e-40 134.8 6.3 6.7e-12 44.7 0.0 7.3 7 1 0 7 7 7 5 DNA gyrase C-terminal domain, beta-propeller Nnf1 PF03980.14 ACT01148.1 - 0.05 14.0 4.6 0.064 13.6 0.8 2.5 1 1 1 2 2 2 0 Nnf1 MRG PF05712.13 ACT01148.1 - 0.14 11.5 0.3 0.29 10.4 0.3 1.4 1 0 0 1 1 1 0 MRG MarR PF01047.22 ACT01150.1 - 1.9e-15 56.5 0.5 2.9e-15 55.9 0.5 1.3 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT01150.1 - 3.9e-10 39.5 0.2 5.5e-10 39.0 0.2 1.2 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT01150.1 - 2.5e-08 34.3 0.1 4.1e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain Dimerisation PF08100.11 ACT01150.1 - 6.7e-05 22.8 0.2 0.00012 22.0 0.2 1.4 1 0 0 1 1 1 1 Dimerisation domain Penicillinase_R PF03965.16 ACT01150.1 - 0.00032 21.0 0.0 0.00041 20.7 0.0 1.1 1 0 0 1 1 1 1 Penicillinase repressor HTH_34 PF13601.6 ACT01150.1 - 0.00035 20.7 0.0 0.00059 20.0 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_5 PF01022.20 ACT01150.1 - 0.094 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Dimerisation2 PF16864.5 ACT01150.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Dimerisation domain HTH_24 PF13412.6 ACT01150.1 - 0.12 12.0 0.8 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding PGA_cap PF09587.10 ACT01151.1 - 8.8e-70 235.1 0.1 1.2e-69 234.7 0.1 1.2 1 0 0 1 1 1 1 Bacterial capsule synthesis protein PGA_cap TALPID3 PF15324.6 ACT01151.1 - 0.0091 13.7 5.5 0.012 13.3 5.5 1.1 1 0 0 1 1 1 1 Hedgehog signalling target PseudoU_synth_2 PF00849.22 ACT01152.1 - 3.9e-31 108.3 0.1 4.9e-31 108.0 0.1 1.1 1 0 0 1 1 1 1 RNA pseudouridylate synthase Methyltrans_SAM PF10672.9 ACT01153.1 - 3.9e-19 68.9 0.0 5.3e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Cons_hypoth95 PF03602.15 ACT01153.1 - 1.2e-08 34.9 0.0 1.6e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 ACT01153.1 - 3e-06 26.9 0.0 4.3e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 ACT01153.1 - 0.0001 22.9 0.0 0.00017 22.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ACT01153.1 - 0.0012 18.4 0.0 0.0019 17.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 ACT01153.1 - 0.0012 19.4 0.0 0.002 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT01153.1 - 0.0038 17.0 0.0 0.0061 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ACT01153.1 - 0.0066 16.1 0.0 0.0089 15.7 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 PAP2 PF01569.21 ACT01154.1 - 4.6e-18 65.3 8.7 4.6e-18 65.3 8.7 2.5 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 ACT01154.1 - 0.00043 20.0 17.1 0.0024 17.6 17.1 2.1 1 1 0 1 1 1 1 PAP2 superfamily BTP PF05232.12 ACT01154.1 - 0.0035 17.4 0.5 0.0035 17.4 0.5 3.3 3 1 2 5 5 5 1 Chlorhexidine efflux transporter Wzy_C PF04932.15 ACT01154.1 - 0.24 11.0 14.0 0.15 11.7 1.8 2.5 2 0 0 2 2 2 0 O-Antigen ligase Exosortase_EpsH PF09721.10 ACT01154.1 - 6.9 6.1 20.3 0.048 13.2 3.3 2.7 2 2 1 3 3 3 0 Transmembrane exosortase (Exosortase_EpsH) HTH_19 PF12844.7 ACT01155.1 - 4.3e-14 52.3 0.1 7.5e-14 51.5 0.0 1.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 ACT01155.1 - 2.3e-12 46.8 0.0 4.3e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ACT01155.1 - 2.1e-10 40.8 0.0 3.8e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 ACT01155.1 - 0.026 14.5 0.1 0.062 13.3 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_26 PF13443.6 ACT01155.1 - 0.047 14.1 0.0 0.1 13.1 0.0 1.5 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain MqsA_antitoxin PF15731.5 ACT01155.1 - 0.13 12.4 0.1 0.31 11.1 0.0 1.6 2 0 0 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA zf-AN1 PF01428.16 ACT01156.1 - 0.11 12.7 2.7 0.79 9.9 0.2 2.1 2 0 0 2 2 2 0 AN1-like Zinc finger Arabinose_Isome PF02610.15 ACT01157.1 - 3e-182 605.7 0.2 3.6e-182 605.4 0.2 1.1 1 0 0 1 1 1 1 L-arabinose isomerase Arabinose_Iso_C PF11762.8 ACT01157.1 - 2.3e-53 178.9 0.1 6.8e-53 177.3 0.0 1.9 2 0 0 2 2 2 1 L-arabinose isomerase C-terminal domain Fucose_iso_C PF02952.17 ACT01157.1 - 0.011 15.4 0.0 0.088 12.5 0.0 2.2 2 0 0 2 2 2 0 L-fucose isomerase, C-terminal domain HTH_42 PF06224.12 ACT01158.1 - 3.2e-75 253.7 0.4 3.7e-75 253.5 0.4 1.0 1 0 0 1 1 1 1 Winged helix DNA-binding domain MFS_1 PF07690.16 ACT01159.1 - 6.4e-39 133.9 48.8 2.8e-36 125.2 39.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01159.1 - 4.8e-13 48.8 33.2 5.5e-10 38.7 12.0 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 ACT01159.1 - 2.6e-11 43.0 28.8 3.1e-07 29.6 10.7 2.4 1 1 1 2 2 2 2 MFS_1 like family MFS_4 PF06779.14 ACT01159.1 - 3.5e-06 26.6 30.1 0.0028 17.0 6.6 2.7 1 1 2 3 3 3 3 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 ACT01159.1 - 8.9e-05 21.1 23.6 0.00085 17.8 22.9 2.5 1 1 0 1 1 1 1 Transmembrane secretion effector BT1 PF03092.16 ACT01159.1 - 0.0025 16.1 4.5 0.0025 16.1 4.5 2.6 3 1 0 3 3 3 1 BT1 family PUCC PF03209.15 ACT01159.1 - 0.0085 15.1 22.6 0.069 12.1 9.6 2.5 2 1 0 2 2 2 2 PUCC protein Vma12 PF11712.8 ACT01159.1 - 0.35 11.0 4.1 1.6 8.8 0.0 2.7 2 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Trp_oprn_chp PF09534.10 ACT01159.1 - 0.43 10.4 20.5 0.12 12.2 5.4 2.9 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2615 PF11027.8 ACT01159.1 - 1.6 8.9 6.0 20 5.4 0.2 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2615) MarR_2 PF12802.7 ACT01160.1 - 6.7e-17 61.1 0.1 1.6e-16 60.0 0.0 1.6 2 0 0 2 2 2 1 MarR family MarR PF01047.22 ACT01160.1 - 1.3e-16 60.2 0.1 3.3e-16 59.0 0.0 1.7 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 ACT01160.1 - 3.7e-11 43.3 0.5 1.9e-10 41.1 0.1 2.0 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_IclR PF09339.10 ACT01160.1 - 8.3e-06 25.5 0.0 1.6e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 ACT01160.1 - 1.1e-05 25.3 0.0 2.3e-05 24.2 0.0 1.7 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 ACT01160.1 - 1.9e-05 24.1 0.0 7.4e-05 22.2 0.0 2.0 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding B-block_TFIIIC PF04182.12 ACT01160.1 - 0.00075 19.6 0.0 0.0033 17.6 0.0 2.0 1 1 0 2 2 2 1 B-block binding subunit of TFIIIC HTH_Crp_2 PF13545.6 ACT01160.1 - 0.0028 17.6 0.1 0.016 15.2 0.0 2.4 2 1 0 2 2 2 1 Crp-like helix-turn-helix domain PadR PF03551.14 ACT01160.1 - 0.0064 16.4 0.2 0.058 13.4 0.0 2.4 2 1 1 3 3 3 1 Transcriptional regulator PadR-like family Penicillinase_R PF03965.16 ACT01160.1 - 0.01 16.1 0.2 0.027 14.8 0.2 1.8 1 1 0 1 1 1 0 Penicillinase repressor Sigma70_r4 PF04545.16 ACT01160.1 - 0.019 14.5 0.8 0.12 11.9 0.0 2.4 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_23 PF13384.6 ACT01160.1 - 0.025 14.4 0.0 0.059 13.2 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain CARD PF00619.21 ACT01160.1 - 0.029 14.4 0.3 0.14 12.2 0.3 1.9 2 0 0 2 2 2 0 Caspase recruitment domain HTH_36 PF13730.6 ACT01160.1 - 0.037 14.0 0.0 0.061 13.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain NPR1_like_C PF12313.8 ACT01160.1 - 0.039 13.5 0.1 0.045 13.3 0.1 1.1 1 0 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal HTH_3 PF01381.22 ACT01160.1 - 0.045 13.8 0.1 0.16 12.1 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix HTH_37 PF13744.6 ACT01160.1 - 0.097 12.6 0.1 0.37 10.8 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Polysacc_deac_1 PF01522.21 ACT01161.1 - 5.4e-35 120.0 0.0 1.1e-34 119.0 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase CactinC_cactus PF09732.9 ACT01161.1 - 0.0078 16.1 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein TPD52 PF04201.15 ACT01161.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Tumour protein D52 family Aminotran_4 PF01063.19 ACT01162.1 - 4e-35 121.7 0.0 4.9e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV LysR_substrate PF03466.20 ACT01163.1 - 2e-30 105.7 0.0 2.7e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01163.1 - 4.9e-23 80.9 0.1 7.4e-23 80.3 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family ATP-synt_D PF01813.17 ACT01163.1 - 0.14 11.9 0.1 0.26 11.1 0.1 1.3 1 0 0 1 1 1 0 ATP synthase subunit D GreA_GreB_N PF03449.15 ACT01164.1 - 4.5e-28 97.2 1.6 7e-28 96.6 1.6 1.3 1 0 0 1 1 1 1 Transcription elongation factor, N-terminal GreA_GreB PF01272.19 ACT01164.1 - 1.8e-25 88.6 0.7 2.9e-25 87.9 0.7 1.3 1 0 0 1 1 1 1 Transcription elongation factor, GreA/GreB, C-term Gal4_dimer PF03902.13 ACT01164.1 - 0.066 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Gal4-like dimerisation domain MCPsignal PF00015.21 ACT01165.1 - 2.1e-46 157.9 42.0 1.4e-43 148.7 24.6 3.5 2 1 1 3 3 3 3 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 ACT01165.1 - 1.7e-18 67.3 0.8 1.7e-18 67.3 0.8 3.5 3 1 1 4 4 4 1 Cache domain HAMP PF00672.25 ACT01165.1 - 2.2e-11 43.9 0.1 2.1e-09 37.6 0.0 4.1 4 1 0 4 4 3 1 HAMP domain dCache_2 PF08269.11 ACT01165.1 - 0.0015 17.8 0.3 0.0015 17.8 0.3 2.8 3 0 0 3 3 3 1 Cache domain DUF948 PF06103.11 ACT01165.1 - 0.35 11.2 34.5 0.13 12.5 2.8 6.5 3 2 1 4 4 3 0 Bacterial protein of unknown function (DUF948) NOG1_N PF17835.1 ACT01165.1 - 0.36 10.8 4.0 12 5.8 0.4 3.5 3 1 1 4 4 4 0 NOG1 N-terminal helical domain Mce4_CUP1 PF11887.8 ACT01165.1 - 0.94 8.9 8.2 4 6.8 1.2 3.5 3 1 1 4 4 4 0 Cholesterol uptake porter CUP1 of Mce4, putative BLOC1_2 PF10046.9 ACT01165.1 - 1.2 9.5 24.3 1 9.7 1.4 4.7 4 2 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PhageMin_Tail PF10145.9 ACT01165.1 - 1.6 8.5 31.8 3.6 7.4 9.9 2.6 1 1 0 2 2 2 0 Phage-related minor tail protein BRE1 PF08647.11 ACT01165.1 - 3.8 7.7 11.7 1.7 8.8 2.3 3.6 4 0 0 4 4 4 0 BRE1 E3 ubiquitin ligase KxDL PF10241.9 ACT01165.1 - 4.7 7.6 6.7 17 5.7 1.8 3.5 1 1 1 2 2 2 0 Uncharacterized conserved protein TACC_C PF05010.14 ACT01165.1 - 5.9 6.6 12.8 0.26 11.0 3.7 3.1 2 2 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal 3-dmu-9_3-mt PF06983.13 ACT01166.1 - 4.4e-09 36.9 0.0 6.2e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase Glyoxalase PF00903.25 ACT01166.1 - 2.6e-07 30.9 0.1 8.3e-07 29.3 0.1 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Acetyltransf_1 PF00583.25 ACT01167.1 - 5.5e-18 65.3 0.0 7e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT01167.1 - 4e-10 39.7 0.0 5.8e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT01167.1 - 2.8e-09 37.2 0.0 4.4e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACT01167.1 - 0.0041 17.2 0.0 0.0072 16.4 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 ACT01167.1 - 0.0074 16.2 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_3 PF13302.7 ACT01167.1 - 0.0091 16.7 0.0 0.012 16.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 ACT01167.1 - 0.15 11.8 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_3 PF13302.7 ACT01168.1 - 2.4e-30 106.0 0.1 2.9e-30 105.8 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT01168.1 - 4.3e-09 36.6 0.1 5.7e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 ACT01168.1 - 3e-05 24.2 0.1 3.7e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT01168.1 - 0.013 15.5 0.0 0.027 14.4 0.0 1.6 1 1 0 1 1 1 0 FR47-like protein Ribosomal_L30 PF00327.20 ACT01168.1 - 0.1 12.5 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L30p/L7e HEAT_2 PF13646.6 ACT01169.1 - 1.7e-05 25.1 0.3 0.62 10.5 0.0 2.9 2 1 1 3 3 3 3 HEAT repeats HEAT PF02985.22 ACT01169.1 - 1.8e-05 24.6 1.1 0.022 15.0 0.0 3.2 3 0 0 3 3 3 2 HEAT repeat DNA_alkylation PF08713.11 ACT01169.1 - 0.00021 21.1 0.0 0.00035 20.4 0.0 1.3 1 0 0 1 1 1 1 DNA alkylation repair enzyme Acetyltransf_10 PF13673.7 ACT01170.1 - 4.9e-08 33.0 0.0 6.7e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT01170.1 - 4.2e-05 23.8 0.0 5.2e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT01170.1 - 8.5e-05 22.9 0.0 0.00013 22.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Glyoxalase PF00903.25 ACT01171.1 - 2.1e-07 31.2 0.0 3e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ACT01171.1 - 2e-05 25.3 0.0 3e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 ACT01171.1 - 6e-05 23.0 0.0 6.7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Collagen PF01391.18 ACT01172.1 - 2e-146 475.8 540.2 6.5e-08 32.2 24.8 20.2 1 1 4 5 5 5 4 Collagen triple helix repeat (20 copies) IBV_3A PF03617.13 ACT01172.1 - 0.35 10.9 1.6 0.53 10.3 0.2 1.9 2 0 0 2 2 2 0 IBV 3A protein Methyltransf_25 PF13649.6 ACT01173.1 - 2.6e-12 47.3 0.0 8.2e-12 45.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT01173.1 - 9.6e-10 38.5 0.1 1.7e-09 37.6 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT01173.1 - 1.3e-07 32.3 0.1 3e-07 31.1 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT01173.1 - 2.1e-07 31.5 0.0 4.7e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT01173.1 - 6.5e-06 26.1 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ACT01173.1 - 2.6e-05 23.9 0.0 4.6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ACT01173.1 - 0.0006 19.3 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 ACT01173.1 - 0.00087 18.8 0.0 0.002 17.6 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.18 ACT01173.1 - 0.0022 17.3 0.0 0.0045 16.4 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 ACT01173.1 - 0.004 17.1 0.0 0.0069 16.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FmrO PF07091.11 ACT01173.1 - 0.0054 16.3 0.0 0.018 14.6 0.0 2.0 2 1 0 2 2 2 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_32 PF13679.6 ACT01173.1 - 0.033 14.2 0.0 0.067 13.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 ACT01173.1 - 0.035 13.0 0.3 0.11 11.3 0.0 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1698) DUF2309 PF10070.9 ACT01173.1 - 0.053 11.9 0.0 0.06 11.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2309) Methyltransf_15 PF09445.10 ACT01173.1 - 0.057 13.0 0.1 0.23 11.0 0.0 2.1 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 ACT01173.1 - 0.077 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TetR_C_19 PF17924.1 ACT01173.1 - 0.2 12.3 4.8 6.8 7.3 0.6 2.9 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain PNKP_ligase PF16542.5 ACT01174.1 - 8.5e-28 97.8 0.1 7.2e-26 91.4 0.1 2.9 1 1 0 1 1 1 1 PNKP adenylyltransferase domain, ligase domain Metallophos PF00149.28 ACT01174.1 - 2.8e-10 41.1 0.8 6.1e-10 39.9 0.8 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AAA_33 PF13671.6 ACT01174.1 - 0.0002 21.5 0.0 0.00044 20.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain Metallophos_2 PF12850.7 ACT01174.1 - 0.00074 19.8 0.2 0.0017 18.6 0.2 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MMR_HSR1 PF01926.23 ACT01174.1 - 0.0011 19.1 0.0 0.003 17.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 ACT01174.1 - 0.017 14.3 0.0 0.032 13.4 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit RNA_ligase PF09414.10 ACT01174.1 - 0.038 14.3 4.7 0.18 12.1 0.6 3.4 3 1 0 3 3 3 0 RNA ligase Speriolin_C PF15059.6 ACT01174.1 - 0.17 12.0 1.3 2.4 8.3 0.1 2.6 2 0 0 2 2 2 0 Speriolin C-terminus DUF4111 PF13427.6 ACT01175.1 - 2.5e-07 30.8 0.0 4.9e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4111) NTP_transf_2 PF01909.23 ACT01175.1 - 0.014 15.6 0.1 0.026 14.8 0.1 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain Polbeta PF18765.1 ACT01175.1 - 0.019 15.0 0.0 0.035 14.2 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase HAD_2 PF13419.6 ACT01176.1 - 5.9e-35 121.0 0.1 7.2e-35 120.7 0.1 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT01176.1 - 3.6e-13 50.3 0.1 1.6e-12 48.2 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT01176.1 - 3.1e-07 30.4 0.0 5.7e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ACT01176.1 - 8.9e-06 26.2 0.0 1.2e-05 25.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_hydro_106 PF17132.4 ACT01177.1 - 0.011 14.1 0.0 0.012 13.9 0.0 1.1 1 0 0 1 1 1 0 alpha-L-rhamnosidase adh_short PF00106.25 ACT01177.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Glyco_hydro2_C5 PF18565.1 ACT01178.1 - 9.1e-31 105.8 0.1 2.2e-30 104.5 0.1 1.7 1 0 0 1 1 1 1 Glycoside hydrolase family 2 C-terminal domain 5 Glyco_hydro_2_C PF02836.17 ACT01178.1 - 9.9e-22 77.4 0.2 1.9e-21 76.5 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 ACT01178.1 - 1.5e-20 73.7 0.1 3.4e-20 72.6 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4982 PF16355.5 ACT01178.1 - 3.2e-17 62.2 0.2 1e-15 57.4 0.0 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4982) Glyco_hydro_2 PF00703.21 ACT01178.1 - 1.5e-16 61.0 0.1 4.3e-16 59.6 0.1 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 CBM_6 PF03422.15 ACT01178.1 - 6.4e-08 32.9 0.9 0.08 13.3 0.0 4.5 5 0 0 5 5 5 2 Carbohydrate binding module (family 6) Invasin_D3 PF09134.10 ACT01178.1 - 0.004 17.4 3.7 0.033 14.5 0.7 3.8 3 1 0 3 3 3 1 Invasin, domain 3 Tudor_4 PF18358.1 ACT01179.1 - 0.045 13.4 0.1 0.062 12.9 0.1 1.2 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain DUF150_C PF17384.2 ACT01179.1 - 0.053 13.7 0.1 0.063 13.4 0.1 1.2 1 0 0 1 1 1 0 RimP C-terminal SH3 domain Glyoxalase PF00903.25 ACT01180.1 - 0.0012 19.0 0.1 0.019 15.1 0.1 2.3 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ACT01180.1 - 0.017 15.0 0.0 0.039 13.9 0.0 1.5 1 1 0 1 1 1 0 Glyoxalase-like domain DUF4038 PF13204.6 ACT01181.1 - 4.4e-21 75.8 4.9 6.5e-21 75.3 4.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) DUF5060 PF16586.5 ACT01181.1 - 4.4e-07 30.2 0.0 0.0016 18.8 0.0 3.2 2 0 0 2 2 2 2 Domain of unknown function (DUF5060) Collagen_bind_2 PF12904.7 ACT01181.1 - 3.7e-06 26.8 0.0 1.1e-05 25.3 0.0 1.8 2 0 0 2 2 2 1 Putative collagen-binding domain of a collagenase LptD PF04453.14 ACT01181.1 - 0.035 13.3 0.1 0.055 12.7 0.1 1.2 1 0 0 1 1 1 0 LPS transport system D DUF3863 PF12979.7 ACT01182.1 - 0.00027 19.9 0.0 0.00048 19.1 0.0 1.4 1 1 0 1 1 1 1 Domain of Unknown Function with PDB structure (DUF3863) Lipase_GDSL_3 PF14606.6 ACT01184.1 - 3.8e-54 183.5 0.0 5.1e-54 183.1 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL_2 PF13472.6 ACT01184.1 - 1.6e-05 25.4 0.0 2.5e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family YdjC PF04794.12 ACT01185.1 - 1.2e-34 120.4 0.0 1.6e-34 119.9 0.0 1.2 1 0 0 1 1 1 1 YdjC-like protein Glyco_hydro_28 PF00295.17 ACT01186.1 - 1.3e-10 40.9 5.9 1.6e-09 37.3 4.6 2.8 1 1 1 2 2 2 2 Glycosyl hydrolases family 28 Beta_helix PF13229.6 ACT01186.1 - 0.00087 19.2 9.2 0.0077 16.1 6.6 3.5 1 1 0 2 2 2 1 Right handed beta helix region Glyco_hydro_63 PF03200.16 ACT01187.1 - 5.3e-06 25.5 2.3 7.3e-05 21.7 0.0 2.9 3 1 1 4 4 4 2 Glycosyl hydrolase family 63 C-terminal domain Trehalase PF01204.18 ACT01187.1 - 0.032 13.1 0.0 0.068 12.0 0.0 1.5 1 1 0 1 1 1 0 Trehalase His_kinase PF06580.13 ACT01188.1 - 2.5e-22 79.0 4.4 3e-22 78.8 2.6 2.2 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACT01188.1 - 3.6e-13 50.0 0.1 7.1e-13 49.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACT01188.1 - 5e-13 49.4 5.0 8.4e-13 48.7 5.0 1.3 1 0 0 1 1 1 1 Cache domain HATPase_c_2 PF13581.6 ACT01188.1 - 9.6e-06 25.6 0.0 1.7e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 ACT01188.1 - 0.00024 20.9 0.2 0.00077 19.3 0.1 1.9 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 ACT01188.1 - 0.00051 19.9 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ACT01189.1 - 8.9e-25 87.0 0.1 1.8e-24 86.1 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT01189.1 - 3.1e-18 65.8 0.2 5.7e-18 65.0 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01189.1 - 9.8e-10 38.3 0.3 0.00048 20.2 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF3502 PF12010.8 ACT01190.1 - 1.2 9.8 6.3 0.66 10.6 1.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF3502) BPD_transp_1 PF00528.22 ACT01191.1 - 1.9e-10 40.8 10.8 1.9e-10 40.8 10.8 2.2 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Epiglycanin_C PF14654.6 ACT01191.1 - 0.082 13.0 0.3 0.082 13.0 0.3 2.1 3 0 0 3 3 3 0 Mucin, catalytic, TM and cytoplasmic tail region BPD_transp_1 PF00528.22 ACT01192.1 - 4.3e-16 59.2 23.0 5e-15 55.7 23.0 2.2 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF3980 PF13140.6 ACT01192.1 - 0.00097 19.5 0.2 0.0052 17.2 0.2 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3980) DUF4044 PF13253.6 ACT01192.1 - 9.8 5.8 7.7 1.4 8.4 2.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4044) GFO_IDH_MocA PF01408.22 ACT01193.1 - 4e-30 105.1 1.3 7.1e-30 104.3 1.3 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT01193.1 - 2.8e-10 40.2 0.0 6e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACT01193.1 - 1.1e-07 32.6 1.4 2e-07 31.7 1.4 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ACT01193.1 - 1.4e-05 25.4 0.8 6.3e-05 23.2 0.8 2.2 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain CoA_binding PF02629.19 ACT01193.1 - 1.5e-05 25.6 1.2 3.1e-05 24.6 1.2 1.5 1 0 0 1 1 1 1 CoA binding domain F420_oxidored PF03807.17 ACT01193.1 - 3.1e-05 24.5 1.3 7.1e-05 23.3 1.3 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 ACT01193.1 - 0.00016 22.1 0.4 0.00032 21.1 0.4 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ACT01193.1 - 0.00034 20.7 1.6 0.00055 20.0 1.1 1.5 2 0 0 2 2 1 1 Shikimate / quinate 5-dehydrogenase Gp_dh_N PF00044.24 ACT01193.1 - 0.00049 20.4 0.1 0.0014 18.9 0.1 1.8 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ACT01193.1 - 0.00072 19.0 0.1 0.0013 18.1 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Rossmann-like PF10727.9 ACT01193.1 - 0.0072 16.2 0.2 0.013 15.4 0.2 1.4 1 0 0 1 1 1 1 Rossmann-like domain 3HCDH_N PF02737.18 ACT01193.1 - 0.016 15.1 0.3 0.031 14.2 0.3 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 ACT01193.1 - 0.016 14.8 0.3 0.028 14.1 0.3 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PglD_N PF17836.1 ACT01193.1 - 0.021 15.5 0.3 0.04 14.6 0.3 1.4 1 0 0 1 1 1 0 PglD N-terminal domain G6PD_N PF00479.22 ACT01193.1 - 0.036 14.7 0.0 0.062 13.9 0.0 1.4 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain TrkA_N PF02254.18 ACT01193.1 - 0.038 14.2 1.2 0.084 13.1 1.2 1.6 1 0 0 1 1 1 0 TrkA-N domain OCD_Mu_crystall PF02423.15 ACT01193.1 - 0.087 11.7 1.1 0.15 11.0 1.1 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family IlvN PF07991.12 ACT01193.1 - 0.091 12.3 0.8 0.15 11.6 0.8 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ox_reductase_C PF08635.10 ACT01193.1 - 0.13 12.0 0.0 0.36 10.5 0.0 1.9 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain AP_endonuc_2 PF01261.24 ACT01194.1 - 6e-24 84.7 0.1 2.7e-22 79.2 0.1 2.2 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel AP_endonuc_2_N PF07582.12 ACT01194.1 - 4.6e-05 23.1 0.0 0.00012 21.7 0.0 1.7 1 0 0 1 1 1 1 AP endonuclease family 2 C terminus Staph_haemo PF05480.11 ACT01194.1 - 0.08 12.7 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Staphylococcus haemolytic protein UxuA PF03786.13 ACT01194.1 - 0.17 10.7 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 D-mannonate dehydratase (UxuA) DUF3502 PF12010.8 ACT01195.1 - 0.012 16.3 1.6 0.17 12.6 0.2 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3502) MAGI_u5 PF16666.5 ACT01195.1 - 0.098 12.8 1.9 11 6.1 1.6 2.3 2 0 0 2 2 2 0 Unstructured region on MAGI Glyco_hydro_52 PF03512.13 ACT01196.1 - 6.6e-186 618.2 0.1 8.8e-186 617.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 52 CBM_4_9 PF02018.17 ACT01197.1 - 6.9e-33 113.8 11.0 2.1e-11 44.3 0.5 5.2 5 1 1 6 6 6 4 Carbohydrate binding domain DUF1735 PF08522.10 ACT01197.1 - 0.026 15.1 2.9 22 5.7 0.1 4.4 4 1 0 4 4 4 0 Domain of unknown function (DUF1735) Sialidase PF02973.16 ACT01197.1 - 0.028 13.9 0.0 0.087 12.3 0.0 1.8 1 0 0 1 1 1 0 Sialidase, N-terminal domain DUF4627 PF15425.6 ACT01197.1 - 0.037 13.6 0.0 0.46 10.1 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4627) DUF642 PF04862.12 ACT01197.1 - 0.062 13.1 0.1 11 5.8 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF642) GPI-anchored PF10342.9 ACT01197.1 - 0.38 11.5 3.8 59 4.5 0.0 4.5 4 1 0 4 4 4 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SLH PF00395.20 ACT01198.1 - 3.9e-39 132.4 0.4 6.9e-12 45.2 0.0 3.7 3 0 0 3 3 3 3 S-layer homology domain fn3 PF00041.21 ACT01198.1 - 1.3e-17 63.9 4.8 4.9e-11 42.8 0.6 3.0 2 0 0 2 2 2 2 Fibronectin type III domain Sortilin-Vps10 PF15902.5 ACT01198.1 - 9.4e-10 37.8 10.2 0.017 14.0 2.0 5.2 3 1 3 6 6 6 5 Sortilin, neurotensin receptor 3, Big_7 PF17957.1 ACT01198.1 - 5.1e-09 36.8 30.9 1.8e-07 31.8 0.0 6.7 6 1 1 7 7 7 3 Bacterial Ig domain BNR PF02012.20 ACT01198.1 - 7.2e-09 34.3 20.4 0.45 10.7 0.2 7.8 7 0 0 7 7 7 4 BNR/Asp-box repeat DUF2369 PF10179.9 ACT01198.1 - 1.3e-05 25.4 0.8 0.094 13.1 0.0 3.0 3 0 0 3 3 3 2 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 ACT01198.1 - 0.00017 22.1 20.6 0.0018 18.8 0.9 4.6 5 1 0 5 5 5 2 Purple acid Phosphatase, N-terminal domain BNR_6 PF15899.5 ACT01198.1 - 0.0031 17.4 6.6 28 5.1 0.1 5.8 5 0 0 5 5 5 0 BNR-Asp box repeat DUF4998 PF16389.5 ACT01198.1 - 0.0088 15.7 0.0 2.7 7.5 0.0 2.8 1 1 1 2 2 2 2 Domain of unknown function fn3_2 PF16893.5 ACT01198.1 - 0.067 13.4 0.0 0.43 10.7 0.0 2.4 2 0 0 2 2 2 0 Fibronectin type III domain PA14 PF07691.12 ACT01199.1 - 5.5e-29 100.9 1.1 1.4e-28 99.6 1.1 1.7 1 0 0 1 1 1 1 PA14 domain Sortilin-Vps10 PF15902.5 ACT01199.1 - 2.3e-20 72.8 5.5 1.6e-07 30.5 0.3 6.1 4 1 1 6 6 6 5 Sortilin, neurotensin receptor 3, GLEYA PF10528.9 ACT01199.1 - 9.6e-06 25.9 0.3 9.6e-06 25.9 0.3 3.8 3 1 0 3 3 3 1 GLEYA domain BNR PF02012.20 ACT01199.1 - 0.053 13.5 0.4 0.053 13.5 0.4 11.4 12 0 0 12 12 12 0 BNR/Asp-box repeat CHB_HEX_C PF03174.13 ACT01199.1 - 2.7 8.1 8.8 7.8 6.6 0.0 5.2 7 0 0 7 7 7 0 Chitobiase/beta-hexosaminidase C-terminal domain Response_reg PF00072.24 ACT01200.1 - 1.3e-23 83.3 0.0 3.1e-23 82.1 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT01200.1 - 1.3e-20 73.4 0.1 6.6e-20 71.2 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01200.1 - 3.8e-14 52.3 0.0 1.1e-06 28.6 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT01200.1 - 4e-08 33.5 0.0 1.1e-07 32.1 0.0 1.7 1 0 0 1 1 1 1 GGDEF-like domain Methyltransf_5 PF01795.19 ACT01200.1 - 0.0083 15.7 0.1 0.018 14.6 0.1 1.5 1 0 0 1 1 1 1 MraW methylase family His_kinase PF06580.13 ACT01201.1 - 3.6e-21 75.3 0.1 1e-20 73.8 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT01201.1 - 9e-16 58.4 3.5 1.7e-15 57.5 3.5 1.4 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 ACT01201.1 - 3.3e-11 43.4 0.0 5.6e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT01201.1 - 1.8e-07 31.6 0.0 3.7e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SBP_bac_8 PF13416.6 ACT01202.1 - 2.1e-18 67.2 1.3 2.8e-18 66.7 1.3 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT01202.1 - 5.1e-17 62.8 4.1 7.3e-17 62.3 4.1 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein LPAM_2 PF13627.6 ACT01202.1 - 4.5 7.2 4.9 8.2 6.4 4.9 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site SBP_bac_1 PF01547.25 ACT01203.1 - 8.8e-24 85.0 14.3 1.3e-23 84.5 14.3 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT01203.1 - 1.3e-21 77.6 10.3 2e-21 77.1 10.3 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT01204.1 - 3.7e-15 56.1 10.3 3.7e-15 56.1 10.3 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT01205.1 - 6.1e-19 68.5 19.7 6.1e-19 68.5 19.7 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component RicinB_lectin_2 PF14200.6 ACT01206.1 - 3.1e-29 101.6 25.7 3.6e-15 56.5 5.1 4.0 1 1 3 4 4 4 3 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 ACT01206.1 - 1.6e-10 41.3 0.7 3.4e-10 40.3 0.7 1.6 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_hydro_39 PF01229.17 ACT01206.1 - 0.032 12.8 0.3 0.053 12.1 0.3 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 Aldo_ket_red PF00248.21 ACT01207.1 - 8.9e-80 268.0 0.0 1e-79 267.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family WcbI PF18588.1 ACT01207.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis enzyme WcbI TetR_N PF00440.23 ACT01208.1 - 3.7e-08 33.0 0.0 7e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_7 PF02796.15 ACT01208.1 - 0.036 14.2 0.0 0.072 13.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_Tnp_1_2 PF13022.6 ACT01208.1 - 0.046 13.9 0.3 0.12 12.5 0.0 1.9 2 1 0 2 2 2 0 Helix-turn-helix of insertion element transposase HTH_22 PF13309.6 ACT01208.1 - 0.047 13.8 0.1 0.15 12.1 0.0 1.9 2 0 0 2 2 2 0 HTH domain KIX PF02172.16 ACT01208.1 - 0.097 12.9 0.2 0.097 12.9 0.2 2.1 2 0 0 2 2 2 0 KIX domain Acetyltransf_3 PF13302.7 ACT01209.1 - 5.2e-29 101.7 0.0 6.1e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT01209.1 - 2.4e-10 40.7 0.0 3.1e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 ACT01209.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT01209.1 - 0.097 13.1 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Lipase_GDSL_2 PF13472.6 ACT01210.1 - 4.8e-19 69.4 0.3 1e-18 68.4 0.3 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ACT01210.1 - 4.6e-06 26.7 0.0 1e-05 25.6 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 ACT01210.1 - 0.031 14.4 0.0 0.047 13.8 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family HTH_18 PF12833.7 ACT01211.1 - 1.7e-20 73.1 0.0 3.3e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01211.1 - 4.3e-16 58.6 0.0 1.2e-13 50.8 0.0 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT01211.1 - 3.2e-06 27.1 0.5 5.7e-06 26.3 0.4 1.6 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT01211.1 - 0.0034 17.1 0.0 0.0051 16.5 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Response_reg PF00072.24 ACT01212.1 - 1.2e-28 99.5 0.2 3.1e-28 98.2 0.0 1.8 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT01212.1 - 1.5e-13 50.8 0.0 4.1e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01212.1 - 6.1e-12 45.3 0.5 4.3e-05 23.5 0.0 2.9 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family His_kinase PF06580.13 ACT01213.1 - 2e-23 82.5 0.3 5.3e-22 77.9 0.2 2.9 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT01213.1 - 1.1e-11 45.0 3.9 2.2e-11 44.0 3.9 1.5 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 ACT01213.1 - 4.4e-11 43.0 0.5 9.7e-11 41.9 0.5 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT01213.1 - 1.5e-05 25.4 0.1 4.4e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sigma_reg_N PF13800.6 ACT01213.1 - 0.93 9.8 3.7 22 5.4 1.2 2.6 2 0 0 2 2 2 0 Sigma factor regulator N-terminal BPD_transp_1 PF00528.22 ACT01214.1 - 7.5e-14 51.9 14.7 7.5e-14 51.9 14.7 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component MNHE PF01899.16 ACT01214.1 - 0.28 10.9 5.4 0.059 13.1 1.2 2.1 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit BPD_transp_1 PF00528.22 ACT01215.1 - 7.3e-14 51.9 27.8 7.6e-13 48.6 27.8 2.1 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF3502 PF12010.8 ACT01216.1 - 1.1e-36 126.3 0.5 1.1e-36 126.3 0.5 2.1 2 1 1 3 3 3 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACT01216.1 - 2.4e-09 37.6 16.0 2.4e-09 37.6 16.0 2.1 2 1 0 2 2 2 1 Bacterial extracellular solute-binding protein Sortilin-Vps10 PF15902.5 ACT01217.1 - 4.7e-23 81.7 8.5 4.2e-10 39.0 1.1 6.2 2 2 3 7 7 7 5 Sortilin, neurotensin receptor 3, BNR PF02012.20 ACT01217.1 - 1.4e-10 39.5 40.8 0.21 11.7 1.1 13.5 13 0 0 13 13 13 6 BNR/Asp-box repeat PA14 PF07691.12 ACT01217.1 - 3e-09 36.9 0.3 1.1e-08 35.0 0.3 2.1 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 ACT01217.1 - 2.7e-05 24.5 3.4 0.00027 21.3 0.8 3.8 3 0 0 3 3 3 1 GLEYA domain Dockerin_1 PF00404.18 ACT01217.1 - 0.0015 18.7 3.5 0.0034 17.5 3.5 1.7 1 0 0 1 1 1 1 Dockerin type I domain BNR_2 PF13088.6 ACT01217.1 - 0.012 14.9 8.5 2.4 7.4 1.5 5.9 4 2 0 4 4 4 0 BNR repeat-like domain SLH PF00395.20 ACT01218.1 - 3.3e-34 116.6 0.0 4.3e-13 49.0 0.0 3.5 3 0 0 3 3 3 3 S-layer homology domain Cohesin PF00963.18 ACT01218.1 - 4.7e-07 30.1 1.9 5.8e-07 29.8 0.4 1.9 2 0 0 2 2 2 1 Cohesin domain Trehalase PF01204.18 ACT01219.1 - 4.3e-11 42.3 0.0 6.5e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Trehalase Glyco_hydro_63 PF03200.16 ACT01219.1 - 3e-07 29.6 1.0 6.3e-05 21.9 0.0 3.1 2 1 1 3 3 3 2 Glycosyl hydrolase family 63 C-terminal domain Bac_rhamnosid6H PF17389.2 ACT01219.1 - 0.00053 19.3 0.0 0.00096 18.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Thymidylate_kin PF02223.17 ACT01219.1 - 0.0039 16.9 0.0 0.16 11.6 0.0 2.2 2 0 0 2 2 2 1 Thymidylate kinase ADP_ribosyl_GH PF03747.14 ACT01220.1 - 2.7e-35 122.5 0.2 3.8e-35 122.1 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Glyco_hydro_38 PF18438.1 ACT01221.1 - 2.5e-37 127.3 0.0 5.2e-37 126.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain 1 Glyco_hydro_38N PF01074.22 ACT01221.1 - 1e-29 103.8 0.1 2.2e-29 102.8 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ACT01221.1 - 1.5e-25 90.5 0.0 2.3e-25 90.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ACT01221.1 - 3.4e-15 56.0 0.3 3.4e-15 56.0 0.3 2.0 2 0 0 2 2 2 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ACT01221.1 - 1.4e-06 28.3 0.0 3.8e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Raffinose_syn PF05691.12 ACT01222.1 - 3.2e-71 240.2 0.0 3e-49 167.5 0.1 3.9 1 1 1 2 2 2 2 Raffinose synthase or seed imbibition protein Sip1 Glyco_hydro_31 PF01055.26 ACT01222.1 - 6.9e-05 22.2 0.1 0.00016 21.0 0.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Melibiase PF02065.18 ACT01222.1 - 0.00012 21.2 0.1 0.0002 20.5 0.1 1.3 1 0 0 1 1 1 1 Melibiase Glyco_hydro_28 PF00295.17 ACT01223.1 - 5.5e-16 58.5 4.8 8.5e-16 57.9 4.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 ACT01223.1 - 0.00045 20.1 5.1 0.00045 20.1 5.1 2.6 1 1 2 3 3 3 2 Right handed beta helix region F5_F8_type_C PF00754.25 ACT01224.1 - 1.5e-35 122.0 28.8 7.8e-20 71.3 1.5 5.9 6 0 0 6 6 6 2 F5/8 type C domain Sortilin-Vps10 PF15902.5 ACT01224.1 - 4.4e-22 78.5 5.1 2.9e-07 29.6 0.3 5.3 4 2 1 5 5 5 4 Sortilin, neurotensin receptor 3, BNR PF02012.20 ACT01224.1 - 7e-07 28.3 59.3 0.13 12.3 0.3 13.4 14 0 0 14 14 14 7 BNR/Asp-box repeat GFO_IDH_MocA PF01408.22 ACT01225.1 - 1e-13 52.1 0.1 1.7e-13 51.5 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT01225.1 - 0.00031 20.7 0.1 0.00068 19.6 0.1 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain ox_reductase_C PF08635.10 ACT01225.1 - 0.026 14.2 0.0 0.065 12.9 0.0 1.7 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain F420_oxidored PF03807.17 ACT01225.1 - 0.037 14.6 0.0 0.08 13.5 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AP_endonuc_2 PF01261.24 ACT01226.1 - 1.7e-23 83.2 0.0 2.2e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Bep_C_terminal PF17841.1 ACT01226.1 - 0.11 12.8 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 BID domain of Bartonella effector protein (Bep) SBP_bac_8 PF13416.6 ACT01227.1 - 4e-30 105.6 11.8 4e-30 105.6 11.8 1.6 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT01227.1 - 1.9e-25 90.5 15.5 2.9e-25 89.9 15.5 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Response_reg PF00072.24 ACT01228.1 - 6e-27 94.0 1.2 1.5e-26 92.7 1.2 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT01228.1 - 6e-17 61.7 0.0 1.7e-16 60.2 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01228.1 - 1.9e-16 59.7 0.0 3.5e-07 30.1 0.0 3.2 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family DNA_pol3_delt_C PF14840.6 ACT01228.1 - 0.081 13.3 0.5 0.22 11.9 0.1 1.9 2 0 0 2 2 2 0 Processivity clamp loader gamma complex DNA pol III C-term His_kinase PF06580.13 ACT01229.1 - 5.5e-21 74.7 1.4 1.4e-20 73.4 1.4 1.7 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT01229.1 - 1e-18 68.0 3.3 1e-18 68.0 3.3 1.5 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACT01229.1 - 1.9e-09 38.0 0.0 3.8e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT01229.1 - 3.2e-09 37.0 0.1 1.1e-08 35.3 0.1 1.9 1 0 0 1 1 1 1 HAMP domain HATPase_c_2 PF13581.6 ACT01229.1 - 0.00033 20.6 0.0 0.00091 19.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACT01229.1 - 0.0012 18.7 0.0 0.0027 17.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FtsX PF02687.21 ACT01229.1 - 0.1 13.1 1.0 1.6 9.2 0.1 2.3 2 0 0 2 2 2 0 FtsX-like permease family BPD_transp_1 PF00528.22 ACT01230.1 - 2.4e-18 66.5 24.7 2.4e-18 66.5 24.7 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT01231.1 - 9.6e-20 71.1 14.8 9.6e-20 71.1 14.8 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2427 PF10348.9 ACT01231.1 - 0.051 13.4 14.8 0.1 12.4 1.5 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF2427) Myco_arth_vir_N PF09610.10 ACT01231.1 - 2.2 8.5 5.9 1.5 9.0 0.6 3.0 3 0 0 3 3 3 0 Mycoplasma virulence signal region (Myco_arth_vir_N) ADP_ribosyl_GH PF03747.14 ACT01232.1 - 2.8e-15 56.8 1.1 2.8e-15 56.8 1.1 1.9 2 1 0 2 2 2 1 ADP-ribosylglycohydrolase CBM_35 PF16990.5 ACT01232.1 - 5.8e-08 33.0 0.0 1.2e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate binding module (family 35) CBM_4_9 PF02018.17 ACT01232.1 - 0.0025 18.1 0.5 0.0097 16.2 0.5 1.9 1 1 0 1 1 1 1 Carbohydrate binding domain CARDB PF07705.11 ACT01232.1 - 0.09 13.0 0.0 0.29 11.4 0.0 1.8 1 0 0 1 1 1 0 CARDB Glyco_hydro_66 PF13199.6 ACT01233.1 - 0.016 13.9 0.2 0.034 12.8 0.2 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 Glyco_hydro_18 PF00704.28 ACT01233.1 - 0.029 14.1 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 18 GHL6 PF14871.6 ACT01233.1 - 0.036 14.2 0.0 0.098 12.8 0.0 1.7 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 GHL10 PF02638.15 ACT01233.1 - 0.041 13.0 0.0 0.072 12.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 Glyco_hydro_79C PF16862.5 ACT01233.1 - 0.18 12.7 0.0 0.46 11.4 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 79 C-terminal beta domain Glyco_hydro_127 PF07944.12 ACT01234.1 - 8.8e-54 182.9 0.1 1.2e-53 182.4 0.1 1.2 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 DUF4838 PF16126.5 ACT01234.1 - 0.0031 16.9 0.1 0.0057 16.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4838) HTH_AraC PF00165.23 ACT01235.1 - 4.2e-18 64.9 1.5 7.3e-08 32.3 0.6 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT01235.1 - 7.8e-17 61.3 0.1 1.3e-16 60.6 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT01235.1 - 6.5e-08 32.6 0.2 1.4e-07 31.5 0.2 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT01235.1 - 1.9e-06 27.5 0.0 3.7e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Fer4_12 PF13353.6 ACT01235.1 - 0.067 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S single cluster domain DUF1971 PF09313.11 ACT01235.1 - 0.15 12.1 0.1 0.28 11.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1971) Glyco_hydro_88 PF07470.13 ACT01236.1 - 6.8e-47 160.2 0.3 8.3e-47 159.9 0.3 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 ACT01236.1 - 0.0021 17.6 0.9 0.78 9.2 0.0 3.5 4 0 0 4 4 4 1 D-glucuronyl C5-epimerase C-terminus Nsp3_PL2pro PF12124.8 ACT01236.1 - 0.054 13.3 0.0 0.44 10.4 0.0 2.4 2 0 0 2 2 2 0 Coronavirus polyprotein cleavage domain DUF2264 PF10022.9 ACT01237.1 - 5.4e-115 384.3 0.0 6.3e-115 384.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) Glyco_hydro_18 PF00704.28 ACT01238.1 - 8.3e-29 101.3 3.0 8.3e-29 101.3 3.0 2.3 1 1 2 3 3 3 1 Glycosyl hydrolases family 18 Methyltransf_25 PF13649.6 ACT01239.1 - 4.7e-17 62.5 0.1 7.9e-17 61.8 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT01239.1 - 1e-14 54.9 0.1 1.8e-14 54.1 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT01239.1 - 1.3e-10 41.3 0.0 1.4e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ACT01239.1 - 1.7e-10 40.7 0.0 2.4e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 ACT01239.1 - 7.3e-06 24.8 0.0 9.3e-06 24.5 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_23 PF13489.6 ACT01239.1 - 0.00011 22.1 0.0 0.00015 21.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 ACT01239.1 - 0.0098 15.0 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.12 ACT01239.1 - 0.012 16.3 0.0 0.019 15.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ACT01239.1 - 0.092 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain FAD_binding_3 PF01494.19 ACT01240.1 - 2.2e-19 69.9 0.2 1.1e-18 67.6 0.2 2.0 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ACT01240.1 - 3.7e-06 26.8 2.2 0.00049 19.8 2.2 2.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ACT01240.1 - 5.7e-06 25.5 0.1 0.014 14.3 0.0 2.5 2 1 1 3 3 3 2 Tryptophan halogenase Lycopene_cycl PF05834.12 ACT01240.1 - 2.7e-05 23.4 4.8 0.045 12.8 0.0 3.1 4 0 0 4 4 4 2 Lycopene cyclase protein FAD_binding_2 PF00890.24 ACT01240.1 - 4.2e-05 22.8 1.1 0.15 11.1 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 ACT01240.1 - 8.5e-05 21.9 0.1 0.00019 20.7 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ACT01240.1 - 0.00029 20.1 0.1 0.0016 17.7 0.1 2.0 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 ACT01240.1 - 0.00059 20.0 0.6 0.0021 18.3 0.1 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GMC_oxred_N PF00732.19 ACT01240.1 - 0.0014 18.0 0.0 0.0044 16.4 0.0 1.7 2 0 0 2 2 2 1 GMC oxidoreductase GIDA PF01134.22 ACT01240.1 - 0.0039 16.3 0.1 0.0075 15.4 0.1 1.5 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 ACT01240.1 - 0.0042 15.8 0.0 0.0068 15.2 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 ACT01240.1 - 0.011 15.1 0.5 0.045 13.1 0.4 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase ThiF PF00899.21 ACT01240.1 - 0.027 13.9 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 ThiF family SE PF08491.10 ACT01240.1 - 0.13 11.3 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase 3HCDH_N PF02737.18 ACT01240.1 - 0.19 11.6 0.3 0.42 10.5 0.0 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polyketide_cyc2 PF10604.9 ACT01241.1 - 7.2e-06 26.3 0.2 9.4e-06 25.9 0.2 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 ACT01241.1 - 0.021 15.0 0.4 0.04 14.1 0.4 1.5 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport ketoacyl-synt PF00109.26 ACT01242.1 - 3.8e-51 174.1 2.9 6e-51 173.5 2.9 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ACT01242.1 - 8.8e-32 109.6 0.4 1.7e-31 108.7 0.0 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 ACT01242.1 - 3.9e-06 26.4 0.6 1e-05 25.1 0.4 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ACT01242.1 - 0.062 12.9 0.0 0.23 11.1 0.0 1.9 1 0 0 1 1 1 0 Thiolase, C-terminal domain Glyoxalase PF00903.25 ACT01243.1 - 3.4e-05 24.0 0.0 6.8e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ACT01243.1 - 0.0012 19.6 0.0 0.0018 19.1 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 ACT01243.1 - 0.058 13.7 0.0 0.34 11.2 0.0 1.9 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Sigma70_r1_1 PF03979.14 ACT01243.1 - 0.093 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 MM_CoA_mutase PF01642.22 ACT01244.1 - 9.1e-142 473.2 0.0 1.4e-141 472.6 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase MeaB PF03308.16 ACT01244.1 - 4.5e-40 137.3 0.6 7.4e-40 136.6 0.6 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB B12-binding PF02310.19 ACT01244.1 - 1e-10 41.7 0.2 2.4e-10 40.5 0.2 1.7 1 0 0 1 1 1 1 B12 binding domain cobW PF02492.19 ACT01244.1 - 1.4e-08 34.5 0.0 3.1e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 ACT01244.1 - 0.015 14.9 0.0 0.046 13.3 0.0 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_18 PF13238.6 ACT01244.1 - 0.022 15.3 0.0 0.062 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain FIST PF08495.10 ACT01244.1 - 0.055 13.5 0.0 0.15 12.1 0.0 1.7 1 1 0 1 1 1 0 FIST N domain AAA_16 PF13191.6 ACT01244.1 - 0.12 12.7 0.2 0.6 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ACT01244.1 - 0.18 12.0 0.2 3.8 7.8 0.0 3.1 3 1 0 3 3 3 0 AAA domain DUF2653 PF10850.8 ACT01246.1 - 6.3e-37 125.7 0.4 7e-37 125.5 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2653) BetaGal_dom4_5 PF13364.6 ACT01246.1 - 0.023 15.3 0.1 1.9 9.1 0.0 2.1 1 1 1 2 2 2 0 Beta-galactosidase jelly roll domain Endomucin PF07010.12 ACT01247.1 - 0.00062 19.8 1.4 0.19 11.7 0.1 2.0 2 0 0 2 2 2 2 Endomucin DUF2207 PF09972.9 ACT01247.1 - 0.015 14.1 0.3 0.016 14.0 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) NPCC PF08058.11 ACT01247.1 - 0.18 11.9 0.1 0.32 11.1 0.1 1.3 1 0 0 1 1 1 0 Nuclear pore complex component DUF3951 PF13131.6 ACT01247.1 - 0.19 12.0 0.2 0.19 12.0 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3951) OAD_gamma PF04277.13 ACT01247.1 - 0.22 12.1 0.1 0.22 12.1 0.1 2.3 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain SARAF PF06682.12 ACT01247.1 - 1.2 8.8 8.7 1.1 8.9 5.3 2.0 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2076 PF09849.9 ACT01247.1 - 1.7 8.7 7.3 2.1 8.3 7.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF309 PF03745.14 ACT01248.1 - 8.1e-23 79.9 0.5 2.5e-22 78.3 0.4 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF309) TPR_14 PF13428.6 ACT01248.1 - 3.1e-05 24.4 1.5 0.01 16.6 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ACT01248.1 - 0.0035 17.9 0.1 0.093 13.4 0.1 2.5 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 ACT01248.1 - 0.014 15.4 0.2 0.067 13.2 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ACT01248.1 - 0.029 14.5 0.1 0.096 12.8 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 ACT01248.1 - 0.048 14.2 0.0 3.2 8.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 ACT01248.1 - 0.062 13.4 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ACT01248.1 - 0.065 12.9 0.0 6.2 6.6 0.0 2.6 2 0 0 2 2 2 0 TPR repeat TPR_10 PF13374.6 ACT01248.1 - 0.14 12.0 2.8 0.16 11.9 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Pro_CA PF00484.19 ACT01249.1 - 2.6e-12 47.3 0.0 4.2e-12 46.6 0.0 1.5 1 1 0 1 1 1 1 Carbonic anhydrase Fe-S_biosyn PF01521.20 ACT01250.1 - 5.4e-17 62.0 0.0 5.8e-17 61.9 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis gpW PF02831.15 ACT01250.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 gpW Peptidase_M32 PF02074.15 ACT01251.1 - 3e-189 629.9 0.0 3.4e-189 629.7 0.0 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase NMT1_2 PF13379.6 ACT01252.1 - 5.5e-22 78.7 0.4 1.5e-21 77.3 0.4 1.6 1 1 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 ACT01252.1 - 4.2e-19 69.4 0.6 6.1e-19 68.8 0.6 1.1 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 ACT01252.1 - 0.0005 19.7 0.2 0.00094 18.8 0.1 1.4 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein LPAM_2 PF13627.6 ACT01252.1 - 2.7 7.9 5.8 5.7 6.9 5.8 1.5 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site ABC_tran PF00005.27 ACT01253.1 - 1.2e-31 110.1 0.0 1.8e-31 109.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01253.1 - 3.3e-06 27.1 0.7 0.056 13.3 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ACT01253.1 - 5.4e-05 23.6 0.5 0.0002 21.8 0.5 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA PF00004.29 ACT01253.1 - 0.00042 20.8 0.0 0.071 13.5 0.1 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ACT01253.1 - 0.00088 19.6 0.0 0.0045 17.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ACT01253.1 - 0.00092 18.6 0.0 0.0037 16.7 0.0 2.0 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 ACT01253.1 - 0.0015 18.2 0.1 0.014 15.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.19 ACT01253.1 - 0.0022 17.5 0.1 1.2 8.5 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_3 PF07726.11 ACT01253.1 - 0.0034 17.2 0.1 0.021 14.7 0.1 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 ACT01253.1 - 0.0039 16.8 0.2 0.011 15.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ACT01253.1 - 0.0083 16.0 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ACT01253.1 - 0.0088 15.8 0.1 0.019 14.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad17 PF03215.15 ACT01253.1 - 0.009 16.0 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_5 PF07728.14 ACT01253.1 - 0.0096 15.9 0.4 0.13 12.3 0.1 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) SRP54 PF00448.22 ACT01253.1 - 0.015 14.9 0.1 0.072 12.7 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_28 PF13521.6 ACT01253.1 - 0.016 15.4 0.8 0.25 11.6 0.2 2.3 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ACT01253.1 - 0.069 12.3 0.1 0.13 11.4 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_7 PF12775.7 ACT01253.1 - 0.079 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region CbiA PF01656.23 ACT01253.1 - 0.088 12.9 0.3 0.88 9.6 0.0 2.1 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_23 PF13476.6 ACT01253.1 - 0.1 13.1 0.0 0.15 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ACT01253.1 - 0.2 11.4 0.0 0.29 10.8 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain TarS_C1 PF18674.1 ACT01253.1 - 0.25 11.3 0.0 0.38 10.7 0.0 1.2 1 0 0 1 1 1 0 TarS beta-glycosyltransferase C-terminal domain 1 AAA_33 PF13671.6 ACT01253.1 - 0.27 11.4 1.1 0.75 10.0 1.1 2.1 1 1 0 1 1 1 0 AAA domain BPD_transp_1 PF00528.22 ACT01254.1 - 6.1e-22 78.2 23.0 6.1e-22 78.2 23.0 1.6 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component FtsX PF02687.21 ACT01254.1 - 0.13 12.7 27.7 0.35 11.4 10.8 2.9 3 0 0 3 3 3 0 FtsX-like permease family MscL PF01741.18 ACT01254.1 - 2.9 8.2 11.4 0.11 12.8 3.6 2.4 2 1 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL PglL_A PF15864.5 ACT01254.1 - 7.6 6.4 11.1 7.6 6.4 5.1 2.7 2 0 0 2 2 2 0 Protein glycosylation ligase ArAE_1_C PF11728.8 ACT01255.1 - 5.8e-43 146.8 4.1 7.5e-43 146.4 4.1 1.1 1 0 0 1 1 1 1 Putative aromatic acid exporter C-terminal domain ArAE_1 PF06081.11 ACT01255.1 - 1.6e-34 119.0 12.0 2.2e-34 118.6 12.0 1.2 1 0 0 1 1 1 1 Aromatic acid exporter family member 1 FUSC_2 PF13515.6 ACT01255.1 - 0.0079 16.3 9.4 0.013 15.6 9.1 1.6 1 1 0 1 1 1 1 Fusaric acid resistance protein-like FUSC PF04632.12 ACT01255.1 - 0.59 8.6 6.8 3.1 6.2 0.4 2.8 2 1 0 3 3 3 0 Fusaric acid resistance protein family CotE PF10628.9 ACT01256.1 - 1.7e-63 213.4 0.0 1.9e-63 213.2 0.0 1.0 1 0 0 1 1 1 1 Outer spore coat protein E (CotE) COOH-NH2_lig PF14395.6 ACT01257.1 - 1.8e-97 325.5 0.0 2.4e-97 325.1 0.0 1.1 1 0 0 1 1 1 1 Phage phiEco32-like COOH.NH2 ligase-type 2 Glyco_trans_1_2 PF13524.6 ACT01258.1 - 2.8e-22 78.9 0.0 8.5e-22 77.4 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 ACT01258.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ACT01259.1 - 1.3e-15 57.5 0.0 2.3e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 MutS_V PF00488.21 ACT01260.1 - 1.5e-78 263.2 0.7 2.3e-78 262.5 0.7 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ACT01260.1 - 5.2e-47 160.6 2.0 1.2e-46 159.3 2.0 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 ACT01260.1 - 6.6e-46 155.2 0.0 1.2e-45 154.4 0.0 1.4 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 ACT01260.1 - 1.3e-28 99.2 0.2 3.3e-28 97.9 0.2 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 ACT01260.1 - 6.6e-11 42.6 0.1 1.9e-10 41.2 0.1 1.9 1 0 0 1 1 1 1 MutS domain II AAA_27 PF13514.6 ACT01260.1 - 0.0033 17.1 0.0 0.0095 15.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ACT01260.1 - 0.047 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 ACT01260.1 - 0.091 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_14 PF13173.6 ACT01260.1 - 0.16 12.0 0.0 1.5 8.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain MutL_C PF08676.11 ACT01261.1 - 8.6e-43 145.6 0.0 1.6e-42 144.7 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 ACT01261.1 - 4.7e-37 126.3 0.0 7.3e-37 125.7 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 ACT01261.1 - 1.9e-08 34.2 0.0 3.2e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ACT01261.1 - 2.8e-07 31.0 0.0 5.8e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mlh1_C PF16413.5 ACT01261.1 - 0.012 15.1 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus SAM_MT PF04445.13 ACT01262.1 - 2.7e-14 53.2 0.0 3.4e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Cons_hypoth95 PF03602.15 ACT01262.1 - 0.0074 15.9 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 IPPT PF01715.17 ACT01263.1 - 2.2e-87 292.6 0.0 2.8e-87 292.3 0.0 1.1 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 ACT01263.1 - 2.1e-07 30.6 0.1 1e-05 25.0 0.0 2.2 2 0 0 2 2 2 1 Isopentenyl transferase AAA_33 PF13671.6 ACT01263.1 - 0.0017 18.6 0.0 0.013 15.7 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ACT01263.1 - 0.012 16.2 0.1 1.6 9.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ACT01263.1 - 0.026 14.9 0.0 0.052 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 ACT01263.1 - 0.13 12.0 0.2 0.89 9.3 0.0 2.3 3 0 0 3 3 3 0 IstB-like ATP binding protein Hfq PF17209.3 ACT01264.1 - 1.1e-33 114.7 0.4 1.3e-33 114.5 0.4 1.1 1 0 0 1 1 1 1 Hfq protein LSM PF01423.22 ACT01264.1 - 0.0013 18.4 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 LSM domain Transgly PF00912.22 ACT01265.1 - 2.4e-62 209.6 0.1 4.1e-62 208.8 0.1 1.4 1 0 0 1 1 1 1 Transglycosylase Transpeptidase PF00905.22 ACT01265.1 - 5.2e-39 134.3 5.1 1.6e-38 132.6 5.1 1.8 1 1 0 1 1 1 1 Penicillin binding protein transpeptidase domain fn3 PF00041.21 ACT01265.1 - 5.6e-05 23.4 0.5 0.00012 22.3 0.5 1.5 1 0 0 1 1 1 1 Fibronectin type III domain FixP_N PF14715.6 ACT01265.1 - 0.047 13.4 1.2 0.12 12.2 1.2 1.6 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Pro_isomerase PF00160.21 ACT01266.1 - 1.5e-41 142.3 0.1 1.7e-41 142.1 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF402 PF04167.13 ACT01267.1 - 1.3e-21 76.5 2.9 2.2e-21 75.8 2.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF402) DUF309 PF03745.14 ACT01267.1 - 0.035 13.8 0.0 0.071 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF309) DUF218 PF02698.17 ACT01268.1 - 2.6e-28 98.6 0.0 3.4e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain AAA PF00004.29 ACT01269.1 - 1e-19 71.3 0.0 1.6e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_6 PF17866.1 ACT01269.1 - 1.3e-14 54.1 0.0 3.3e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 AAA lid domain RuvB_N PF05496.12 ACT01269.1 - 4.1e-06 26.6 0.1 1.8e-05 24.6 0.1 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ACT01269.1 - 5.9e-06 26.6 0.0 0.082 13.2 0.0 2.3 1 1 1 2 2 2 2 AAA domain Mg_chelatase PF01078.21 ACT01269.1 - 6.3e-05 22.4 0.3 0.013 14.9 0.1 2.2 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ACT01269.1 - 0.00013 22.0 0.0 0.00023 21.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 ACT01269.1 - 0.00022 21.0 0.1 0.00042 20.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ACT01269.1 - 0.0058 15.8 0.1 0.11 11.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 ACT01269.1 - 0.0058 16.4 0.2 0.13 12.0 0.2 2.4 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.6 ACT01269.1 - 0.0086 16.6 0.0 0.02 15.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT01269.1 - 0.016 15.6 0.0 0.029 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 ACT01269.1 - 0.021 14.7 0.1 0.036 14.0 0.1 1.4 1 0 0 1 1 1 0 NTPase AAA_2 PF07724.14 ACT01269.1 - 0.031 14.4 0.1 0.048 13.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Viral_helicase1 PF01443.18 ACT01269.1 - 0.089 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 ACT01269.1 - 0.094 13.0 0.4 0.28 11.5 0.2 1.7 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.6 ACT01269.1 - 0.1 13.0 0.2 0.23 11.9 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 ACT01269.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) GTP-bdg_N PF13167.6 ACT01270.1 - 5.8e-32 110.2 0.5 1.2e-31 109.2 0.5 1.6 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal GTP-bdg_M PF16360.5 ACT01270.1 - 3.2e-31 107.8 4.1 7.1e-31 106.6 4.1 1.6 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region MMR_HSR1 PF01926.23 ACT01270.1 - 1.8e-20 73.2 0.0 4.4e-20 71.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ACT01270.1 - 5.9e-07 29.1 0.2 1.2e-06 28.2 0.2 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 ACT01270.1 - 0.00023 20.7 0.0 0.003 17.0 0.0 2.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Dynamin_N PF00350.23 ACT01270.1 - 0.00049 20.2 0.0 0.075 13.1 0.0 2.4 1 1 1 2 2 2 1 Dynamin family cobW PF02492.19 ACT01270.1 - 0.0011 18.6 0.2 0.3 10.7 0.0 2.6 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 ACT01270.1 - 0.0038 17.1 0.4 1.1 9.1 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 ACT01270.1 - 0.0095 15.9 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain ABC_tran PF00005.27 ACT01270.1 - 0.048 14.2 0.0 0.23 12.0 0.0 2.2 1 1 1 2 2 2 0 ABC transporter G-alpha PF00503.20 ACT01270.1 - 0.093 11.9 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit Rho_N PF07498.12 ACT01270.1 - 0.21 11.6 0.8 4 7.4 0.1 2.6 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain Met_gamma_lyase PF06838.11 ACT01271.1 - 8e-192 637.2 0.0 9.3e-192 637.0 0.0 1.0 1 0 0 1 1 1 1 Methionine gamma-lyase Cys_Met_Meta_PP PF01053.20 ACT01271.1 - 0.00084 18.0 0.0 0.0012 17.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ACT01271.1 - 0.0034 16.4 0.0 0.0052 15.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V YAcAr PF10686.9 ACT01271.1 - 0.11 12.5 0.1 16 5.6 0.1 2.7 2 0 0 2 2 2 0 YspA, cpYpsA-related SLOG family MerR_1 PF13411.6 ACT01272.1 - 1.1e-19 70.3 0.2 2.2e-19 69.3 0.0 1.5 2 0 0 2 2 2 1 MerR HTH family regulatory protein MerR PF00376.23 ACT01272.1 - 1.9e-11 43.6 0.0 4.8e-11 42.2 0.0 1.8 1 0 0 1 1 1 1 MerR family regulatory protein DUF5572 PF17733.1 ACT01272.1 - 0.0013 18.5 0.2 0.0024 17.7 0.2 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Gln-synt_C PF00120.24 ACT01273.1 - 9.1e-141 468.8 0.0 1.1e-140 468.5 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 ACT01273.1 - 1.4e-31 108.1 0.0 2.6e-31 107.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Gln-synt_N_2 PF16952.5 ACT01273.1 - 0.0098 15.7 0.1 0.21 11.4 0.1 2.4 1 1 0 1 1 1 1 Glutamine synthetase N-terminal domain TFIIA_gamma_N PF02268.16 ACT01273.1 - 0.096 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit, helical domain PspC PF04024.12 ACT01274.1 - 3.1e-18 65.3 0.2 3.6e-18 65.1 0.2 1.1 1 0 0 1 1 1 1 PspC domain NqrM PF04400.13 ACT01274.1 - 0.14 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 (Na+)-NQR maturation NqrM LexA_DNA_bind PF01726.16 ACT01275.1 - 3.8e-28 97.1 0.1 5.8e-28 96.5 0.1 1.3 1 0 0 1 1 1 1 LexA DNA binding domain Peptidase_S24 PF00717.23 ACT01275.1 - 3e-19 68.7 0.4 4.4e-19 68.2 0.4 1.3 1 0 0 1 1 1 1 Peptidase S24-like MarR PF01047.22 ACT01275.1 - 5.2e-05 23.1 0.0 0.00012 21.9 0.0 1.6 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT01275.1 - 6.1e-05 22.8 0.0 8.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT01275.1 - 7.1e-05 22.3 0.1 0.0002 20.9 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.10 ACT01275.1 - 0.00015 21.5 0.0 0.0004 20.1 0.0 1.7 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT01275.1 - 0.0017 18.3 0.0 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain TrmB PF01978.19 ACT01275.1 - 0.0092 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 ACT01275.1 - 0.011 15.6 0.0 0.032 14.2 0.0 1.9 2 1 0 2 2 2 0 HTH domain FaeA PF04703.12 ACT01275.1 - 0.015 15.6 0.0 0.028 14.8 0.0 1.4 1 0 0 1 1 1 0 FaeA-like protein Penicillinase_R PF03965.16 ACT01275.1 - 0.035 14.5 0.0 0.43 10.9 0.0 2.1 2 0 0 2 2 2 0 Penicillinase repressor HTH_20 PF12840.7 ACT01275.1 - 0.035 14.2 0.0 0.056 13.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain KfrA_N PF11740.8 ACT01275.1 - 0.043 14.5 0.0 0.073 13.8 0.0 1.3 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term HTH_28 PF13518.6 ACT01275.1 - 0.047 13.8 0.0 0.087 13.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_5 PF01022.20 ACT01275.1 - 0.081 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family BLACT_WH PF17778.1 ACT01275.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase associated winged helix domain LysM PF01476.20 ACT01276.1 - 4.6e-11 42.6 0.0 1e-10 41.5 0.0 1.6 1 1 0 1 1 1 1 LysM domain DUF1772 PF08592.11 ACT01276.1 - 0.0078 16.5 0.1 0.0098 16.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) DUF4131 PF13567.6 ACT01276.1 - 0.057 13.1 0.2 0.16 11.6 0.2 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF896 PF05979.12 ACT01277.1 - 4.2e-24 84.2 0.7 4.5e-24 84.1 0.7 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF896) CTV_P33 PF07184.11 ACT01277.1 - 0.11 11.6 0.0 0.11 11.5 0.0 1.0 1 0 0 1 1 1 0 Citrus tristeza virus P33 protein EbsA PF17255.2 ACT01278.1 - 0.0084 16.5 0.1 0.012 15.9 0.1 1.3 1 0 0 1 1 1 1 EbsA-like protein HAD_2 PF13419.6 ACT01279.1 - 6.4e-23 81.7 0.0 1.2e-21 77.6 0.0 2.0 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT01279.1 - 3.1e-18 66.8 0.0 4.2e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT01279.1 - 1.5e-13 50.6 0.0 3.7e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like PGP_phosphatase PF09419.10 ACT01279.1 - 6.5e-05 22.6 0.0 0.00026 20.6 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase HAD PF12710.7 ACT01279.1 - 0.0014 19.0 0.6 0.035 14.5 0.6 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase ARD PF03079.14 ACT01280.1 - 8.9e-34 116.9 0.5 1e-33 116.8 0.5 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 ACT01280.1 - 4e-06 26.4 0.3 7.7e-06 25.5 0.3 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ACT01280.1 - 0.00028 20.5 0.1 0.001 18.7 0.0 1.8 2 0 0 2 2 2 1 Cupin AraC_binding PF02311.19 ACT01280.1 - 0.0024 17.8 0.0 0.004 17.1 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain DUF3418 PF11898.8 ACT01280.1 - 0.069 11.8 0.0 0.071 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) S-methyl_trans PF02574.16 ACT01281.1 - 1e-74 251.8 0.0 1.9e-74 250.8 0.0 1.5 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Met_synt_B12 PF02965.17 ACT01281.1 - 7.1e-62 209.3 0.0 1.3e-61 208.5 0.0 1.4 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain Pterin_bind PF00809.22 ACT01281.1 - 9.2e-44 149.9 0.0 4.1e-43 147.8 0.0 2.0 2 0 0 2 2 2 1 Pterin binding enzyme B12-binding_2 PF02607.17 ACT01281.1 - 6.2e-22 77.8 0.2 2e-21 76.2 0.2 2.0 1 0 0 1 1 1 1 B12 binding domain B12-binding PF02310.19 ACT01281.1 - 5.3e-19 68.4 0.4 1.9e-18 66.6 0.1 2.2 2 0 0 2 2 2 1 B12 binding domain Lactamase_B_2 PF12706.7 ACT01282.1 - 3.9e-19 69.0 0.0 2.9e-09 36.8 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACT01282.1 - 4.2e-08 33.4 0.1 1.8e-07 31.4 0.1 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 ACT01282.1 - 0.00012 21.7 0.0 0.00023 20.8 0.0 1.4 1 0 0 1 1 1 1 tRNase Z endonuclease YdjM PF04307.14 ACT01283.1 - 4.9e-23 81.3 12.8 6.9e-23 80.8 12.8 1.3 1 0 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase DEAD PF00270.29 ACT01284.1 - 5.2e-29 101.2 0.1 2.7e-28 98.9 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF1998 PF09369.10 ACT01284.1 - 3.4e-19 69.4 0.1 7.5e-19 68.3 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 ACT01284.1 - 9.7e-14 51.7 0.1 6.3e-13 49.0 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT01284.1 - 2.2e-08 34.3 0.0 5.9e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SUV3_C PF12513.8 ACT01284.1 - 0.1 12.5 0.0 1.2 9.1 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial degradasome RNA helicase subunit C terminal RNase_H_2 PF13482.6 ACT01285.1 - 4.2e-34 117.9 0.0 7e-34 117.2 0.0 1.3 1 0 0 1 1 1 1 RNase_H superfamily DNA_pol_B_exo1 PF03104.19 ACT01285.1 - 0.00045 19.5 0.1 0.00068 18.9 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_exo2 PF10108.9 ACT01285.1 - 0.00053 19.7 0.0 0.00091 19.0 0.0 1.3 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB TPR_2 PF07719.17 ACT01285.1 - 0.00078 19.4 5.7 3.9 7.8 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ACT01285.1 - 0.0013 19.0 6.2 0.045 14.1 2.3 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ACT01285.1 - 0.21 11.5 14.7 0.24 11.3 0.2 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 ACT01285.1 - 0.23 11.8 0.9 7.5 7.0 0.6 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Hydrolase_6 PF13344.6 ACT01286.1 - 1.1e-28 99.3 0.0 2.2e-28 98.3 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT01286.1 - 2.5e-20 72.3 0.0 9.2e-20 70.5 0.0 2.0 3 0 0 3 3 3 1 HAD-hyrolase-like Hydrolase PF00702.26 ACT01286.1 - 1.1e-08 35.6 0.0 1.7e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ACT01286.1 - 3.8e-07 30.4 0.0 0.00013 22.1 0.0 2.7 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase FleQ PF06490.11 ACT01286.1 - 0.14 12.5 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ H2TH PF06831.14 ACT01287.1 - 7e-23 80.4 0.0 1.1e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Fapy_DNA_glyco PF01149.24 ACT01287.1 - 4.2e-21 75.7 0.0 7.4e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain zf-FPG_IleRS PF06827.14 ACT01287.1 - 2.8e-07 30.2 1.2 6.3e-07 29.1 1.2 1.6 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS FbpA PF05833.11 ACT01287.1 - 1.2e-06 27.6 0.0 1.6e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Ribosomal_S13 PF00416.22 ACT01287.1 - 0.018 15.4 0.0 0.038 14.4 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein S13/S18 Zn_Tnp_IS1595 PF12760.7 ACT01287.1 - 0.059 13.4 0.8 0.13 12.2 0.8 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain AP_endonuc_2 PF01261.24 ACT01288.1 - 9e-23 80.8 0.0 1.2e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF1861 PF08950.10 ACT01288.1 - 0.014 14.7 0.1 1.7 7.8 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1861) FtsJ PF01728.19 ACT01290.1 - 5.5e-13 49.4 0.0 1.4e-12 48.1 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 ACT01290.1 - 7.9e-05 23.3 0.0 0.00031 21.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT01290.1 - 0.0017 19.0 0.0 0.0045 17.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain THUMP PF02926.17 ACT01290.1 - 0.0038 17.3 0.1 0.0067 16.5 0.1 1.4 1 0 0 1 1 1 1 THUMP domain Methyltransf_23 PF13489.6 ACT01290.1 - 0.019 14.8 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF956 PF06115.11 ACT01290.1 - 0.12 12.1 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF956) Pkinase PF00069.25 ACT01291.1 - 3.7e-34 118.3 0.0 5.1e-34 117.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ACT01291.1 - 2.9e-25 89.0 0.0 4.1e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ACT01291.1 - 5.4e-05 23.2 0.7 0.00056 19.9 0.0 2.6 2 1 0 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ACT01291.1 - 0.0023 17.0 0.0 0.0035 16.4 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 ACT01291.1 - 0.009 15.0 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ACT01291.1 - 0.023 14.3 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Response_reg PF00072.24 ACT01292.1 - 1.4e-28 99.3 0.0 2e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT01292.1 - 1.5e-25 89.1 0.5 3.5e-25 87.9 0.5 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HATPase_c PF02518.26 ACT01293.1 - 9.9e-27 93.7 0.1 2e-26 92.7 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT01293.1 - 2.4e-15 56.3 1.1 1.3e-14 53.9 0.1 2.6 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT01293.1 - 3.3e-07 30.6 0.5 1e-06 29.0 0.1 2.1 2 0 0 2 2 2 1 HAMP domain HATPase_c_3 PF13589.6 ACT01293.1 - 0.00081 19.2 0.0 0.0022 17.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ArlS_N PF18719.1 ACT01293.1 - 0.017 15.3 1.2 0.03 14.5 0.2 1.9 2 0 0 2 2 2 0 ArlS sensor domain IFT20 PF14931.6 ACT01293.1 - 0.019 15.1 1.7 0.059 13.6 1.7 1.7 1 1 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 HATPase_c_2 PF13581.6 ACT01293.1 - 0.027 14.4 0.3 0.093 12.7 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain SLC3A2_N PF16028.5 ACT01293.1 - 8.8 6.0 6.1 8.3 6.0 3.8 2.2 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus CN_hydrolase PF00795.22 ACT01294.1 - 2.5e-30 105.7 0.0 3e-30 105.5 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Lipase_GDSL_2 PF13472.6 ACT01294.1 - 0.004 17.6 0.0 0.096 13.1 0.0 2.3 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Acetyltransf_1 PF00583.25 ACT01295.1 - 1.5e-11 44.6 0.0 2.5e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 ACT01295.1 - 2.1e-05 24.6 0.0 0.016 15.3 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT01295.1 - 0.00054 20.3 0.1 0.0015 19.0 0.1 1.8 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT01295.1 - 0.014 15.3 0.0 0.037 14.0 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain MOZ_SAS PF01853.18 ACT01295.1 - 0.1 12.3 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 MOZ/SAS family Acetyltransf_1 PF00583.25 ACT01296.1 - 0.018 15.2 0.1 0.062 13.5 0.0 1.9 1 1 1 2 2 2 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT01296.1 - 0.025 14.5 0.0 0.085 12.8 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT01296.1 - 0.06 13.8 0.1 0.29 11.6 0.1 2.1 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT01296.1 - 0.1 12.7 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Lactamase_B_2 PF12706.7 ACT01297.1 - 7.4e-18 64.8 0.0 9.4e-18 64.5 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACT01297.1 - 1.1e-10 41.8 0.0 1.5e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 ACT01297.1 - 0.047 13.1 0.0 0.11 11.9 0.0 1.6 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain Abhydro_lipase PF04083.16 ACT01298.1 - 0.16 11.5 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region MutS_V PF00488.21 ACT01299.1 - 3.1e-32 112.1 0.0 4.9e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 MutS domain V TPK_catalytic PF04263.16 ACT01300.1 - 5.9e-22 78.0 0.0 8.9e-22 77.4 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 ACT01300.1 - 1e-12 47.5 0.0 1.9e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain UPF0126 PF03458.13 ACT01301.1 - 1.5e-39 133.7 20.3 1.3e-19 69.8 7.2 2.3 2 0 0 2 2 2 2 UPF0126 domain TRIC PF05197.13 ACT01301.1 - 0.0015 18.1 1.2 0.42 10.2 0.2 2.5 2 1 0 2 2 2 2 TRIC channel DUF2070 PF09843.9 ACT01301.1 - 4 5.6 9.3 5.1 5.3 9.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) LMWPc PF01451.21 ACT01302.1 - 5.1e-38 130.7 0.0 5.7e-38 130.5 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Esterase PF00756.20 ACT01303.1 - 5.3e-38 131.1 0.0 6.5e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 ACT01303.1 - 0.013 15.3 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 ACT01303.1 - 0.029 14.0 0.0 0.043 13.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ACT01303.1 - 0.03 13.6 0.0 0.041 13.1 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 E1_dh PF00676.20 ACT01304.1 - 4.7e-92 308.1 0.0 5.4e-92 307.9 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 ACT01304.1 - 1.3e-05 24.6 1.1 1.6e-05 24.3 0.2 1.5 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 ACT01304.1 - 0.0015 18.4 1.1 0.0015 18.4 1.1 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Transket_pyr PF02779.24 ACT01305.1 - 2.4e-44 151.1 0.1 3.8e-44 150.5 0.1 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ACT01305.1 - 8.9e-42 141.9 1.1 8.9e-42 141.9 1.1 1.6 2 0 0 2 2 2 1 Transketolase, C-terminal domain PFOR_II PF17147.4 ACT01305.1 - 4.4e-05 23.7 0.2 7.9e-05 22.9 0.2 1.4 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Aminotran_5 PF00266.19 ACT01305.1 - 0.081 11.9 1.1 0.12 11.4 1.1 1.1 1 0 0 1 1 1 0 Aminotransferase class-V 2-oxoacid_dh PF00198.23 ACT01306.1 - 6.4e-90 300.7 0.0 1.5e-89 299.5 0.0 1.5 2 0 0 2 2 2 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ACT01306.1 - 1.1e-17 63.6 3.5 2.4e-17 62.5 3.5 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 ACT01306.1 - 1.7e-17 63.5 0.1 5.6e-17 61.8 0.1 2.0 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 ACT01306.1 - 2.6e-07 30.4 2.8 0.00095 18.9 0.1 2.5 2 0 0 2 2 2 2 Biotin-lipoyl like GCV_H PF01597.19 ACT01306.1 - 0.0021 18.0 0.3 0.0044 16.9 0.3 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 ACT01306.1 - 0.015 15.3 1.3 0.036 14.0 1.3 1.7 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain ATP-synt_ab_Xtn PF16886.5 ACT01306.1 - 0.097 12.5 0.8 0.21 11.4 0.8 1.5 1 0 0 1 1 1 0 ATPsynthase alpha/beta subunit N-term extension HlyD_3 PF13437.6 ACT01306.1 - 0.13 13.0 2.5 10 6.8 0.1 3.4 2 1 1 3 3 3 0 HlyD family secretion protein HlyD_2 PF12700.7 ACT01306.1 - 0.24 10.1 2.1 1.7 7.3 0.2 2.0 2 0 0 2 2 2 0 HlyD family secretion protein Ribosomal_60s PF00428.19 ACT01306.1 - 4.4 8.0 35.4 0.49 11.0 8.1 3.5 3 0 0 3 3 3 0 60s Acidic ribosomal protein Pyr_redox_2 PF07992.14 ACT01307.1 - 5.8e-66 222.7 3.9 5.8e-66 222.7 3.9 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ACT01307.1 - 1e-36 125.5 0.1 2.5e-36 124.3 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ACT01307.1 - 1.1e-20 73.9 11.8 9e-19 67.8 0.7 3.9 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ACT01307.1 - 4.3e-11 42.5 2.6 1.1e-08 34.6 0.1 2.6 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ACT01307.1 - 5e-07 29.1 1.8 5e-07 29.1 1.8 2.5 3 0 0 3 3 3 1 FAD binding domain Pyr_redox_3 PF13738.6 ACT01307.1 - 6.4e-07 28.9 10.5 4.6e-06 26.1 10.5 2.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ACT01307.1 - 8.6e-07 28.6 0.6 8.6e-07 28.6 0.6 2.3 2 1 1 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ACT01307.1 - 5.1e-06 25.5 8.7 8.8e-05 21.4 0.8 3.3 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.6 ACT01307.1 - 1.6e-05 25.1 3.6 0.00083 19.5 0.5 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ACT01307.1 - 0.00018 20.9 10.2 0.027 13.7 0.7 3.2 3 0 0 3 3 3 3 FAD binding domain UDPG_MGDP_dh_N PF03721.14 ACT01307.1 - 0.0049 16.5 7.6 0.0058 16.2 0.4 2.7 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Lycopene_cycl PF05834.12 ACT01307.1 - 0.0088 15.1 2.1 0.42 9.6 0.1 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 ACT01307.1 - 0.049 12.9 12.1 0.38 10.0 0.8 3.8 4 1 1 5 5 5 0 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 ACT01307.1 - 0.077 12.6 16.0 0.33 10.5 1.5 3.9 4 0 0 4 4 4 0 FAD dependent oxidoreductase TrkA_N PF02254.18 ACT01307.1 - 0.14 12.4 2.5 3.9 7.8 0.2 2.8 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.6 ACT01307.1 - 0.23 11.9 1.6 11 6.5 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Thi4 PF01946.17 ACT01307.1 - 2.6 7.2 9.3 1.3 8.2 0.1 3.3 3 1 1 4 4 4 0 Thi4 family Trp_halogenase PF04820.14 ACT01307.1 - 3.2 6.5 6.1 0.12 11.2 0.5 1.5 2 0 0 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.18 ACT01307.1 - 4.4 7.2 5.5 1.9 8.3 0.5 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ACT01307.1 - 6.1 6.2 6.1 13 5.1 0.4 3.1 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 4HBT PF03061.22 ACT01308.1 - 1.5e-18 66.9 0.4 2.3e-18 66.3 0.4 1.3 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.19 ACT01308.1 - 0.018 14.6 0.6 0.035 13.7 0.2 1.6 2 0 0 2 2 2 0 MaoC like domain Phage_Gp111 PF07410.11 ACT01308.1 - 0.056 13.9 0.8 0.13 12.8 0.8 1.7 1 1 0 1 1 1 0 Streptococcus thermophilus bacteriophage Gp111 protein YiiD_C PF09500.10 ACT01308.1 - 0.083 12.7 0.1 0.14 12.0 0.1 1.5 1 1 0 1 1 1 0 Putative thioesterase (yiiD_Cterm) 4HBT_2 PF13279.6 ACT01308.1 - 0.087 13.3 0.1 0.11 13.0 0.1 1.2 1 0 0 1 1 1 0 Thioesterase-like superfamily tRNA_anti-codon PF01336.25 ACT01308.1 - 0.088 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Thymidylat_synt PF00303.19 ACT01309.1 - 1e-120 401.9 0.0 1.4e-120 401.4 0.0 1.2 1 0 0 1 1 1 1 Thymidylate synthase DHFR_1 PF00186.19 ACT01310.1 - 1e-56 191.1 0.0 1.2e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Dihydrofolate reductase Pyr_redox_2 PF07992.14 ACT01311.1 - 6.5e-26 91.2 2.5 3.4e-25 88.9 2.5 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 ACT01311.1 - 7.5e-21 74.0 0.0 1.4e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 ACT01311.1 - 4.6e-11 42.8 0.9 1.6e-10 41.1 0.1 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 ACT01311.1 - 7.5e-11 42.4 4.6 2.1e-07 31.4 0.7 3.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ACT01311.1 - 2.9e-10 40.1 3.2 1.2e-08 34.8 0.1 2.8 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ACT01311.1 - 6.5e-09 35.5 1.7 0.0018 17.6 0.0 3.2 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT01311.1 - 1.4e-08 34.8 0.7 0.00012 21.8 0.3 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 ACT01311.1 - 5.2e-08 32.0 2.0 2.2e-06 26.7 0.2 2.4 2 0 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.24 ACT01311.1 - 5.8e-08 32.5 0.4 3.4e-07 29.9 0.2 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase GIDA PF01134.22 ACT01311.1 - 1.5e-07 30.9 1.6 0.00039 19.6 0.1 2.9 3 0 0 3 3 3 2 Glucose inhibited division protein A NAD_binding_7 PF13241.6 ACT01311.1 - 3.9e-07 30.4 1.3 0.0064 16.9 0.1 2.6 2 1 0 2 2 2 2 Putative NAD(P)-binding FAD_binding_2 PF00890.24 ACT01311.1 - 1.3e-06 27.7 4.6 2e-06 27.2 0.4 2.3 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 ACT01311.1 - 8.5e-06 25.2 0.9 0.00015 21.1 0.1 2.3 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 ACT01311.1 - 5.7e-05 22.5 1.0 0.00018 20.9 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 ACT01311.1 - 0.00015 21.2 2.7 0.016 14.5 0.2 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FMO-like PF00743.19 ACT01311.1 - 0.00025 19.6 0.0 0.034 12.6 0.0 2.1 1 1 0 2 2 2 1 Flavin-binding monooxygenase-like Shikimate_DH PF01488.20 ACT01311.1 - 0.0018 18.3 0.4 4.1 7.5 0.1 3.0 2 1 1 3 3 3 2 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 ACT01311.1 - 0.0026 17.4 0.0 0.0069 16.0 0.0 1.8 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.23 ACT01311.1 - 0.0032 17.5 0.1 0.026 14.5 0.0 2.2 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 ACT01311.1 - 0.004 16.5 0.2 0.075 12.4 0.1 2.4 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain YjeF_N PF03853.15 ACT01311.1 - 0.0099 15.8 2.3 0.33 10.8 0.1 2.3 1 1 0 2 2 2 1 YjeF-related protein N-terminus 3HCDH_N PF02737.18 ACT01311.1 - 0.018 15.0 1.5 0.037 13.9 0.1 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DJ-1_PfpI PF01965.24 ACT01311.1 - 0.018 14.9 3.6 6.6 6.5 0.1 3.4 2 1 1 4 4 3 0 DJ-1/PfpI family IlvN PF07991.12 ACT01311.1 - 0.021 14.4 0.9 0.061 12.9 0.1 2.0 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain PALP PF00291.25 ACT01311.1 - 0.031 13.7 0.3 0.14 11.5 0.0 1.9 1 1 1 2 2 2 0 Pyridoxal-phosphate dependent enzyme Lycopene_cycl PF05834.12 ACT01311.1 - 0.032 13.3 0.3 0.032 13.3 0.3 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein TrkA_N PF02254.18 ACT01311.1 - 0.04 14.2 0.1 4.3 7.6 0.1 3.0 2 1 0 2 2 2 0 TrkA-N domain NAD_binding_9 PF13454.6 ACT01311.1 - 0.054 13.5 1.3 0.4 10.6 0.1 2.9 3 1 0 3 3 3 0 FAD-NAD(P)-binding F420_oxidored PF03807.17 ACT01311.1 - 0.056 14.0 0.1 2.6 8.7 0.0 3.2 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ACT01311.1 - 0.057 13.6 0.1 0.16 12.1 0.1 1.9 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.14 ACT01311.1 - 0.066 12.8 0.0 0.41 10.2 0.0 2.1 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain K_oxygenase PF13434.6 ACT01311.1 - 0.075 12.2 0.1 9 5.3 0.0 2.3 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Ldh_1_N PF00056.23 ACT01311.1 - 0.089 12.9 0.6 15 5.7 0.2 2.7 1 1 1 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain DUF364 PF04016.12 ACT01311.1 - 0.1 12.1 0.0 0.74 9.4 0.0 2.2 1 1 1 2 2 2 0 Putative heavy-metal chelation AdoHcyase_NAD PF00670.21 ACT01311.1 - 0.17 12.0 5.8 0.61 10.1 0.4 2.5 1 1 1 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Spermine_synth PF01564.17 ACT01311.1 - 0.19 11.1 0.1 17 4.7 0.1 2.2 2 0 0 2 2 2 0 Spermine/spermidine synthase domain Trp_halogenase PF04820.14 ACT01311.1 - 0.28 10.0 2.4 0.17 10.7 0.2 1.7 2 0 0 2 2 2 0 Tryptophan halogenase Glucosaminidase PF01832.20 ACT01313.1 - 6.1e-06 26.7 0.2 1.2e-05 25.7 0.2 1.5 1 0 0 1 1 1 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Topoisom_bac PF01131.20 ACT01314.1 - 1.1e-110 370.5 2.0 1.4e-110 370.1 2.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 ACT01314.1 - 2.1e-11 43.9 0.0 5.2e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Toprim domain Toprim_Crpt PF13342.6 ACT01314.1 - 2.9e-08 33.5 0.3 1.1e-07 31.8 0.1 2.1 2 0 0 2 2 2 1 C-terminal repeat of topoisomerase HAD_2 PF13419.6 ACT01315.1 - 7.3e-14 52.2 0.6 1.5e-13 51.2 0.6 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT01315.1 - 1.4e-05 25.5 0.0 2.9e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT01315.1 - 0.00097 19.2 0.0 0.0016 18.5 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ACT01315.1 - 0.0093 16.4 0.9 0.18 12.2 0.9 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2278 PF10042.9 ACT01315.1 - 0.13 12.3 0.1 0.17 11.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2278) ABC_tran PF00005.27 ACT01318.1 - 1.1e-25 90.7 0.0 1.5e-25 90.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ACT01318.1 - 0.00019 21.9 1.2 0.0016 18.9 1.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT01318.1 - 0.00022 21.5 0.1 0.0048 17.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 ACT01318.1 - 0.0012 18.3 0.1 1.4 8.3 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 ACT01318.1 - 0.0023 17.6 0.1 0.052 13.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ACT01318.1 - 0.0026 17.7 0.1 0.0052 16.7 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_21 PF13304.6 ACT01318.1 - 0.0047 16.8 0.0 0.78 9.5 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 ACT01318.1 - 0.034 14.3 0.2 0.12 12.5 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ACT01318.1 - 0.042 14.1 0.0 0.2 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ACT01318.1 - 0.059 13.1 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT01318.1 - 0.11 12.3 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase ATP-synt_ab PF00006.25 ACT01318.1 - 0.28 10.8 0.8 0.95 9.1 0.8 1.8 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Acetyltransf_10 PF13673.7 ACT01319.1 - 1.1e-13 51.2 0.0 7e-13 48.6 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT01319.1 - 6.1e-12 45.8 0.1 8.2e-12 45.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 ACT01319.1 - 2.7e-10 40.4 0.0 4.4e-06 26.8 0.0 2.0 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT01319.1 - 1.5e-08 35.0 0.0 2.4e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT01319.1 - 0.028 14.4 0.0 0.047 13.7 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.6 ACT01319.1 - 0.059 13.5 0.1 0.1 12.8 0.1 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_16 PF05301.11 ACT01319.1 - 0.2 11.4 0.0 0.26 11.0 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 DUF3298 PF11738.8 ACT01320.1 - 4.2e-17 62.9 2.5 1.1e-15 58.4 1.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3298) PdaC PF13739.6 ACT01320.1 - 5.6e-11 43.3 0.0 1.2e-10 42.2 0.0 1.6 1 0 0 1 1 1 1 Deacetylase PdaC CRM1_repeat_3 PF18787.1 ACT01321.1 - 0.00011 22.3 0.2 0.00017 21.7 0.2 1.4 1 0 0 1 1 1 1 CRM1 / Exportin repeat 3 UPF0242 PF06785.11 ACT01321.1 - 0.13 12.3 2.0 0.17 12.0 2.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus MOSC PF03473.17 ACT01322.1 - 2.6e-21 76.0 0.0 4e-21 75.4 0.0 1.3 1 0 0 1 1 1 1 MOSC domain 3-alpha PF03475.14 ACT01322.1 - 5.5e-13 48.6 0.1 8.9e-13 47.9 0.1 1.4 1 0 0 1 1 1 1 3-alpha domain APH PF01636.23 ACT01323.1 - 3.2e-20 73.1 0.0 4.3e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family YdjC PF04794.12 ACT01324.1 - 4.5e-49 167.6 0.0 5.2e-49 167.3 0.0 1.0 1 0 0 1 1 1 1 YdjC-like protein Nup54_C PF18437.1 ACT01324.1 - 0.083 12.8 0.2 0.083 12.8 0.2 2.3 2 0 0 2 2 2 0 Nup54 C-terminal interacting domain YcxB PF14317.6 ACT01325.1 - 5.1e-16 58.1 1.0 7.2e-16 57.7 1.0 1.2 1 0 0 1 1 1 1 YcxB-like protein Got1 PF04178.12 ACT01325.1 - 0.038 14.4 2.6 0.057 13.9 2.6 1.2 1 0 0 1 1 1 0 Got1/Sft2-like family AAA_3 PF07726.11 ACT01326.1 - 1.5e-63 212.5 0.0 2.4e-63 211.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 ACT01326.1 - 1.8e-22 78.9 0.8 3e-22 78.2 0.8 1.4 1 0 0 1 1 1 1 AAA lid domain AAA_5 PF07728.14 ACT01326.1 - 1.1e-16 61.0 0.0 5.4e-16 58.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ACT01326.1 - 2.8e-08 34.3 0.0 1.6e-07 31.8 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ACT01326.1 - 9.1e-07 28.5 0.1 0.00094 18.6 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ACT01326.1 - 4.2e-06 26.6 0.0 2.6e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain RuvB_N PF05496.12 ACT01326.1 - 0.00022 21.0 0.0 0.0026 17.5 0.0 2.3 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain MCM PF00493.23 ACT01326.1 - 0.00073 18.7 0.0 0.0016 17.6 0.0 1.6 1 1 0 1 1 1 1 MCM P-loop domain AAA_2 PF07724.14 ACT01326.1 - 0.023 14.8 0.0 1.8 8.6 0.0 3.1 2 2 0 2 2 2 0 AAA domain (Cdc48 subfamily) MCM_lid PF17855.1 ACT01326.1 - 0.033 14.6 0.1 0.077 13.4 0.1 1.6 1 1 0 1 1 1 0 MCM AAA-lid domain TsaE PF02367.17 ACT01326.1 - 0.11 12.6 0.3 0.23 11.5 0.1 1.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF58 PF01882.18 ACT01327.1 - 5.8e-16 58.5 0.3 1.4e-15 57.3 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function DUF58 DUF4129 PF13559.6 ACT01328.1 - 1.1e-11 44.8 1.7 1.6e-11 44.3 0.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4129) GFD1 PF17331.2 ACT01328.1 - 0.055 13.7 1.7 0.12 12.6 1.7 1.6 1 0 0 1 1 1 0 GFD1 mRNA transport factor Pyr_redox_3 PF13738.6 ACT01329.1 - 1.8e-87 293.4 0.0 2.1e-87 293.2 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ACT01329.1 - 1.2e-32 113.4 0.0 1.4e-32 113.1 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT01329.1 - 1.4e-10 41.6 1.2 5.3e-06 26.9 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ACT01329.1 - 3.5e-08 33.0 0.4 3.6e-06 26.4 0.0 2.1 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 ACT01329.1 - 1e-07 31.0 1.5 0.0028 16.4 0.2 4.0 4 0 0 4 4 4 2 HI0933-like protein FAD_binding_3 PF01494.19 ACT01329.1 - 1.4e-07 31.1 4.1 3.3e-05 23.3 0.1 3.2 3 1 0 3 3 3 2 FAD binding domain DAO PF01266.24 ACT01329.1 - 2.6e-07 30.5 3.1 0.021 14.4 0.1 3.8 3 1 1 4 4 4 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ACT01329.1 - 2.3e-06 27.0 3.3 0.0017 17.5 0.1 3.9 4 0 0 4 4 4 1 FAD binding domain NAD_binding_8 PF13450.6 ACT01329.1 - 1.3e-05 25.3 0.3 0.0016 18.6 0.1 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ACT01329.1 - 1.3e-05 24.6 1.4 0.0045 16.3 0.1 2.6 3 0 0 3 3 3 2 Thi4 family GIDA PF01134.22 ACT01329.1 - 4e-05 22.9 0.5 0.071 12.2 0.0 3.5 4 0 0 4 4 4 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 ACT01329.1 - 6.7e-05 22.4 1.1 0.15 11.4 0.1 2.9 3 0 0 3 3 3 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ACT01329.1 - 0.0032 16.6 0.1 0.023 13.7 0.0 2.3 3 1 0 3 3 3 1 Lycopene cyclase protein NAD_binding_7 PF13241.6 ACT01329.1 - 0.014 15.8 0.0 0.38 11.2 0.0 2.4 2 1 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_9 PF13454.6 ACT01329.1 - 0.02 14.9 1.7 3.9 7.5 0.0 2.4 1 1 1 2 2 2 0 FAD-NAD(P)-binding FMO-like PF00743.19 ACT01329.1 - 0.03 12.7 0.4 0.33 9.3 0.0 2.4 2 1 1 3 3 3 0 Flavin-binding monooxygenase-like ABC_membrane PF00664.23 ACT01331.1 - 1.3e-49 169.3 12.9 1.9e-49 168.8 12.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT01331.1 - 5.4e-35 120.9 0.0 1e-34 120.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT01331.1 - 2e-06 27.4 0.0 0.00067 19.2 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT01331.1 - 0.003 17.4 0.2 0.027 14.3 0.1 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ACT01331.1 - 0.006 16.5 0.0 0.031 14.2 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 ACT01331.1 - 0.0086 16.2 0.5 0.022 14.8 0.5 1.6 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_29 PF13555.6 ACT01331.1 - 0.015 15.1 0.2 0.041 13.6 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 ACT01331.1 - 0.027 13.8 0.1 0.097 11.9 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.6 ACT01331.1 - 0.041 14.3 1.2 0.12 12.7 0.5 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 ACT01331.1 - 0.044 14.0 0.7 2.2 8.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ACT01331.1 - 0.06 13.6 0.0 0.55 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ACT01331.1 - 0.094 12.7 0.0 3.3 7.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MgtE PF01769.16 ACT01331.1 - 6.2 7.2 10.8 1.2 9.6 1.0 3.2 3 0 0 3 3 3 0 Divalent cation transporter ABC_membrane PF00664.23 ACT01332.1 - 1.8e-51 175.4 8.1 2.4e-51 175.0 8.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT01332.1 - 4.9e-34 117.8 0.0 8.2e-34 117.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane_3 PF13748.6 ACT01332.1 - 0.00041 19.7 3.8 0.00079 18.7 2.3 2.0 1 1 0 1 1 1 1 ABC transporter transmembrane region AAA_30 PF13604.6 ACT01332.1 - 0.00042 20.1 0.1 0.00093 19.0 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT01332.1 - 0.00053 20.4 1.0 0.0012 19.2 0.2 2.0 2 1 0 2 2 1 1 AAA ATPase domain SMC_N PF02463.19 ACT01332.1 - 0.00058 19.4 0.4 0.019 14.4 0.4 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ACT01332.1 - 0.00059 19.8 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ACT01332.1 - 0.0017 18.7 0.5 0.022 15.0 0.5 2.3 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ACT01332.1 - 0.0018 18.4 0.5 0.012 15.6 0.5 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase DEAD PF00270.29 ACT01332.1 - 0.0019 18.0 0.1 0.0044 16.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_29 PF13555.6 ACT01332.1 - 0.0027 17.4 0.0 0.0077 16.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain MeaB PF03308.16 ACT01332.1 - 0.0096 14.9 0.0 0.021 13.8 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 ACT01332.1 - 0.023 14.2 0.1 0.09 12.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_10 PF12846.7 ACT01332.1 - 0.026 13.4 0.0 0.056 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain SbcCD_C PF13558.6 ACT01332.1 - 0.028 14.7 0.2 0.38 11.0 0.2 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 ACT01332.1 - 0.028 14.2 1.1 1.3 8.8 0.1 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 ACT01332.1 - 0.03 14.3 0.3 0.75 9.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF4136 PF13590.6 ACT01332.1 - 0.032 14.8 0.0 0.08 13.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4136) AAA PF00004.29 ACT01332.1 - 0.035 14.5 0.4 0.76 10.2 0.4 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ACT01332.1 - 0.041 14.4 0.0 0.078 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 ACT01332.1 - 0.044 13.9 0.2 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain Zeta_toxin PF06414.12 ACT01332.1 - 0.071 12.4 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin ATP_bind_1 PF03029.17 ACT01332.1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein IstB_IS21 PF01695.17 ACT01332.1 - 0.12 12.1 0.0 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Phage_integrase PF00589.22 ACT01333.1 - 3.3e-27 95.4 0.9 3.3e-27 95.4 0.9 1.5 2 0 0 2 2 2 1 Phage integrase family Phage_int_SAM_1 PF02899.17 ACT01333.1 - 2.6e-07 30.8 0.7 3.6e-06 27.2 0.1 3.1 3 1 0 3 3 3 1 Phage integrase, N-terminal SAM-like domain Hydrolase_2 PF07486.12 ACT01334.1 - 2.8e-28 98.8 0.0 4.7e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 Cell Wall Hydrolase PG_binding_1 PF01471.18 ACT01334.1 - 7.2e-15 54.9 0.7 4.4e-14 52.4 0.2 2.2 2 0 0 2 2 2 1 Putative peptidoglycan binding domain YceG PF02618.16 ACT01334.1 - 0.0039 16.8 0.3 0.019 14.6 0.1 1.9 1 1 1 2 2 2 1 YceG-like family WW PF00397.26 ACT01334.1 - 0.0039 17.2 0.0 0.0097 16.0 0.0 1.6 1 0 0 1 1 1 1 WW domain DUF4823 PF16105.5 ACT01334.1 - 0.062 13.2 0.1 0.097 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4823) HERV-K_REC PF15695.5 ACT01334.1 - 0.45 10.6 2.8 6.7 6.8 0.1 2.4 2 1 0 2 2 2 0 Rec (regulator of expression encoded by corf) of HERV-K-113 Rib_5-P_isom_A PF06026.14 ACT01335.1 - 5.8e-69 231.1 0.0 7e-69 230.9 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 ACT01335.1 - 7.9e-06 25.9 0.4 9.5e-05 22.4 0.1 2.1 2 0 0 2 2 2 1 DeoR C terminal sensor domain CoA_trans PF01144.23 ACT01335.1 - 0.038 13.4 0.0 0.07 12.5 0.0 1.4 1 0 0 1 1 1 0 Coenzyme A transferase Metallophos_2 PF12850.7 ACT01336.1 - 5.8e-24 85.1 0.2 1.2e-23 84.1 0.1 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 ACT01336.1 - 1.2e-09 39.0 2.1 2.1e-09 38.2 2.2 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase FBPase_2 PF06874.11 ACT01336.1 - 0.022 13.1 0.6 0.044 12.1 0.6 1.5 1 1 0 1 1 1 0 Firmicute fructose-1,6-bisphosphatase SLH PF00395.20 ACT01337.1 - 1.6e-33 114.4 1.8 6.9e-12 45.2 0.2 4.2 3 0 0 3 3 3 3 S-layer homology domain DUF4430 PF14478.6 ACT01337.1 - 9.4e-31 106.2 7.4 2.1e-21 76.3 1.5 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF4430) SQHop_cyclase_C PF13243.6 ACT01337.1 - 2.1e-09 36.9 0.2 0.00087 18.5 0.0 2.6 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain TED_complement PF07678.14 ACT01337.1 - 4.9e-07 29.1 0.1 0.027 13.5 0.0 2.5 2 0 0 2 2 2 2 A-macroglobulin TED domain Prenyltrans PF00432.21 ACT01337.1 - 0.00019 21.1 0.1 14 5.5 0.0 4.7 4 0 0 4 4 4 1 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 ACT01337.1 - 0.0018 17.5 0.0 1.1 8.2 0.0 2.4 2 0 0 2 2 2 2 Squalene-hopene cyclase N-terminal domain FIVAR PF07554.13 ACT01337.1 - 8.5 7.2 10.6 0.41 11.5 2.6 3.2 3 0 0 3 3 3 0 FIVAR domain DUF4430 PF14478.6 ACT01338.1 - 3.6e-19 69.1 0.3 6.1e-19 68.4 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4430) SpoIIIAH PF12685.7 ACT01338.1 - 0.018 14.8 1.1 0.031 14.1 0.9 1.5 1 1 0 1 1 1 0 SpoIIIAH-like protein SMYLE_N PF18615.1 ACT01338.1 - 0.57 9.7 1.5 0.61 9.6 0.7 1.4 1 1 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain CbiQ PF02361.16 ACT01339.1 - 9.4e-10 38.5 8.1 9.4e-10 38.5 8.1 1.9 2 0 0 2 2 2 1 Cobalt transport protein ABC_tran PF00005.27 ACT01340.1 - 1.3e-54 184.4 0.0 7e-28 97.8 0.0 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACT01340.1 - 4.2e-19 69.5 6.1 7.7e-06 25.9 0.1 4.2 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT01340.1 - 1.4e-12 47.5 1.7 1.4e-05 24.7 0.1 3.6 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT01340.1 - 1.3e-07 31.2 0.4 0.00041 20.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT01340.1 - 1.3e-06 28.9 0.4 0.00015 22.2 0.2 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 ACT01340.1 - 1.4e-06 28.2 0.3 0.023 14.4 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 ACT01340.1 - 1.5e-06 28.9 1.4 0.0099 16.4 0.0 2.5 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 ACT01340.1 - 8.5e-06 25.8 0.1 0.0085 16.0 0.0 2.9 3 1 0 3 3 3 1 RsgA GTPase SbcCD_C PF13558.6 ACT01340.1 - 3.8e-05 23.8 1.4 0.33 11.2 0.1 4.0 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 ACT01340.1 - 8.4e-05 22.2 0.0 1.1 8.8 0.0 3.8 4 0 0 4 4 4 2 AAA domain AAA_22 PF13401.6 ACT01340.1 - 0.00069 19.9 5.2 0.056 13.7 0.2 3.3 2 2 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ACT01340.1 - 0.00075 20.0 0.1 0.092 13.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 ACT01340.1 - 0.0021 18.3 0.0 1.8 8.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ACT01340.1 - 0.0021 17.5 0.3 0.82 9.0 0.0 3.5 3 1 1 4 4 4 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 ACT01340.1 - 0.0087 15.4 0.1 0.45 9.8 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 ACT01340.1 - 0.01 15.5 3.5 1.9 8.2 0.0 3.3 4 0 0 4 4 4 0 AAA domain MobB PF03205.14 ACT01340.1 - 0.012 15.5 0.2 0.18 11.7 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_15 PF13175.6 ACT01340.1 - 0.013 15.2 2.5 0.65 9.6 0.1 2.9 3 0 0 3 3 3 0 AAA ATPase domain AAA_19 PF13245.6 ACT01340.1 - 0.018 15.4 0.3 3.1 8.1 0.1 2.6 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 ACT01340.1 - 0.022 14.7 2.8 0.27 11.1 0.1 2.6 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 ACT01340.1 - 0.03 14.5 0.4 1.3 9.1 0.1 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ACT01340.1 - 0.038 14.4 0.1 4.7 7.7 0.0 2.8 2 0 0 2 2 2 0 RNA helicase T2SSE PF00437.20 ACT01340.1 - 0.039 13.0 0.1 3.6 6.6 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein G-alpha PF00503.20 ACT01340.1 - 0.044 12.9 0.2 0.1 11.7 0.1 1.6 2 0 0 2 2 2 0 G-protein alpha subunit NB-ARC PF00931.22 ACT01340.1 - 0.058 12.6 0.9 1.1 8.4 0.1 2.7 3 0 0 3 3 3 0 NB-ARC domain PRK PF00485.18 ACT01340.1 - 0.097 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family MeaB PF03308.16 ACT01340.1 - 0.12 11.3 0.0 0.27 10.2 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_27 PF13514.6 ACT01340.1 - 0.13 11.8 0.1 3.7 7.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ACT01340.1 - 0.14 11.6 0.5 14 5.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Rad17 PF03215.15 ACT01340.1 - 0.16 11.9 0.0 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_17 PF13207.6 ACT01340.1 - 0.16 12.4 2.9 4.4 7.7 0.1 3.0 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 ACT01340.1 - 0.19 12.1 2.3 10 6.5 0.6 3.5 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 ACT01340.1 - 0.35 9.6 2.6 22 3.7 0.0 3.8 4 1 0 4 4 4 0 Predicted ATPase of the ABC class AAA_5 PF07728.14 ACT01340.1 - 0.35 10.9 1.2 23 5.0 0.1 2.9 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) CbiA PF01656.23 ACT01340.1 - 0.95 9.5 2.9 0.89 9.6 0.1 2.3 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ECF-ribofla_trS PF07155.12 ACT01341.1 - 1.8e-12 47.6 15.1 1.8e-12 47.6 15.1 1.5 2 0 0 2 2 2 1 ECF-type riboflavin transporter, S component ECF_trnsprt PF12822.7 ACT01341.1 - 6.2e-10 39.4 21.8 6.2e-10 39.4 21.8 2.1 2 0 0 2 2 2 1 ECF transporter, substrate-specific component Acetyltransf_1 PF00583.25 ACT01342.1 - 2.4e-10 40.7 0.0 2.9e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT01342.1 - 8.9e-06 25.7 0.0 1.1e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT01342.1 - 2.6e-05 24.6 0.0 3.2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT01342.1 - 0.0058 16.6 0.0 0.0092 15.9 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ACT01342.1 - 0.0094 16.6 0.0 0.013 16.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACT01342.1 - 0.014 15.5 0.0 0.025 14.7 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ACT01342.1 - 0.054 13.2 0.0 0.1 12.3 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain LysE PF01810.18 ACT01343.1 - 3.2e-27 95.3 17.6 4e-27 94.9 17.6 1.0 1 0 0 1 1 1 1 LysE type translocator DUF373 PF04123.13 ACT01343.1 - 0.031 13.7 8.3 0.044 13.2 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) TerC PF03741.16 ACT01343.1 - 0.043 13.5 14.2 0.71 9.5 14.0 2.2 1 1 0 1 1 1 0 Integral membrane protein TerC family Keratin_assoc PF09775.9 ACT01343.1 - 0.25 11.0 4.9 0.22 11.2 3.0 1.8 1 1 1 2 2 2 0 Keratinocyte-associated protein 2 SPW PF03779.14 ACT01343.1 - 0.39 10.3 17.6 0.82 9.3 5.7 4.4 3 2 1 4 4 4 0 SPW repeat DUF4730 PF15873.5 ACT01343.1 - 0.68 10.2 7.3 0.3 11.4 1.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4730) DUF1129 PF06570.11 ACT01343.1 - 2.5 7.6 8.7 2.4 7.6 7.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) DUF4064 PF13273.6 ACT01343.1 - 8.7 6.7 17.4 20 5.5 14.6 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) YceI PF04264.13 ACT01344.1 - 8.8e-47 159.3 2.2 9.8e-47 159.2 2.2 1.0 1 0 0 1 1 1 1 YceI-like domain Helicase_C_2 PF13307.6 ACT01345.1 - 6.4e-28 98.1 0.0 1.1e-27 97.3 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD PF00270.29 ACT01345.1 - 3e-05 23.9 0.0 0.0022 17.8 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 ACT01345.1 - 0.0017 18.4 0.0 0.012 15.7 0.0 2.3 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD_2 PF06733.15 ACT01345.1 - 0.18 11.4 0.0 0.45 10.1 0.0 1.7 2 0 0 2 2 2 0 DEAD_2 Acetyltransf_1 PF00583.25 ACT01346.1 - 1.8e-15 57.2 0.0 2.1e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT01346.1 - 2.7e-12 46.9 0.1 3.7e-12 46.5 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT01346.1 - 1e-10 41.6 0.0 1.3e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT01346.1 - 3.1e-08 33.5 0.0 4.6e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ACT01346.1 - 2.2e-05 24.5 0.1 3.4e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 ACT01346.1 - 4.7e-05 24.1 0.0 5.5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 ACT01346.1 - 0.016 14.8 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase PanZ PF12568.8 ACT01346.1 - 0.027 14.2 0.1 0.036 13.8 0.1 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_4 PF13420.7 ACT01346.1 - 0.048 13.8 0.0 0.057 13.6 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NMT PF01233.19 ACT01346.1 - 0.071 13.0 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_13 PF13880.6 ACT01346.1 - 0.077 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase LysR_substrate PF03466.20 ACT01347.1 - 1.1e-35 122.9 0.0 1.3e-35 122.6 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01347.1 - 4.5e-20 71.3 0.0 2.8e-18 65.6 0.0 2.3 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 ACT01347.1 - 0.052 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain LNP1 PF15419.6 ACT01347.1 - 0.065 13.5 0.0 0.096 12.9 0.0 1.2 1 0 0 1 1 1 0 Leukemia NUP98 fusion partner 1 HTH_20 PF12840.7 ACT01347.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain G6PD_C PF02781.16 ACT01348.1 - 4.7e-97 324.7 0.0 6e-97 324.3 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ACT01348.1 - 2.3e-61 207.5 0.0 4.3e-61 206.6 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain TetR_C_34 PF17929.1 ACT01348.1 - 0.014 15.5 0.3 0.059 13.5 0.0 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Transketolase_N PF00456.21 ACT01349.1 - 2.4e-145 483.7 0.5 3.3e-145 483.2 0.5 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ACT01349.1 - 4.1e-47 160.1 0.0 1.1e-46 158.7 0.0 1.8 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ACT01349.1 - 5.6e-15 55.3 0.0 2.7e-14 53.1 0.0 2.2 2 0 0 2 2 2 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 ACT01349.1 - 7.1e-10 38.5 0.0 3.1e-07 29.9 0.1 2.3 1 1 0 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 ACT01349.1 - 1.3e-05 24.4 0.0 3e-05 23.1 0.0 1.6 2 0 0 2 2 2 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 ACT01349.1 - 0.0013 18.5 2.7 0.089 12.6 2.5 3.2 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF498 PF04430.14 ACT01349.1 - 0.02 15.0 0.0 0.051 13.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) TAL_FSA PF00923.19 ACT01350.1 - 1e-55 189.1 2.7 2.9e-55 187.6 2.7 1.7 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Nudix_N PF12535.8 ACT01351.1 - 2.1e-25 88.0 1.4 3.6e-25 87.3 1.4 1.4 1 0 0 1 1 1 1 Hydrolase of X-linked nucleoside diphosphate N terminal NUDIX PF00293.28 ACT01351.1 - 3.2e-10 40.1 0.0 4.6e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Chromate_transp PF02417.15 ACT01352.1 - 1.6e-74 249.3 36.0 1.4e-41 142.2 17.2 2.3 2 0 0 2 2 2 2 Chromate transporter UcrQ PF02939.16 ACT01352.1 - 0.034 14.1 0.0 0.083 12.8 0.0 1.6 1 0 0 1 1 1 0 UcrQ family Acetyltransf_1 PF00583.25 ACT01354.1 - 1.9e-08 34.5 0.0 2.5e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT01354.1 - 2.2e-08 34.1 0.0 2.5e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT01354.1 - 4.5e-07 30.2 0.0 5.7e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACT01354.1 - 0.093 12.9 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain APH PF01636.23 ACT01355.1 - 2.7e-09 37.3 0.1 3.5e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ACT01355.1 - 7.1e-09 35.6 0.0 1e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 ACT01355.1 - 7e-06 25.2 0.0 1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 ACT01355.1 - 1.7e-05 24.3 0.0 0.00091 18.6 0.0 2.2 1 1 0 1 1 1 1 Ecdysteroid kinase LPAM_1 PF08139.12 ACT01356.1 - 0.16 12.5 1.3 0.25 11.9 1.3 1.4 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Dabb PF07876.12 ACT01358.1 - 1.5e-15 57.6 0.0 1.5e-15 57.5 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain ABM PF03992.16 ACT01358.1 - 0.0033 17.5 0.0 0.0039 17.3 0.0 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF1129 PF06570.11 ACT01359.1 - 0.017 14.6 2.3 0.017 14.6 2.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) adh_short PF00106.25 ACT01360.1 - 2.1e-34 118.7 0.0 2.6e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT01360.1 - 2.9e-23 82.6 0.0 3.6e-23 82.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT01360.1 - 4.2e-07 30.0 0.2 1.3e-06 28.5 0.2 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ACT01360.1 - 0.0017 17.9 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACT01360.1 - 0.031 13.7 0.0 0.047 13.1 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ACT01360.1 - 0.081 12.0 0.0 0.66 9.0 0.0 2.0 2 0 0 2 2 2 0 RmlD substrate binding domain Methyltransf_25 PF13649.6 ACT01361.1 - 6.8e-11 42.7 0.0 1.2e-10 42.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT01361.1 - 8.7e-11 42.3 0.0 1.3e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT01361.1 - 1.7e-09 37.6 0.0 9.6e-09 35.2 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT01361.1 - 8.4e-07 29.7 0.0 1.5e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.12 ACT01361.1 - 0.028 14.2 0.1 0.087 12.6 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF938) TPMT PF05724.11 ACT01361.1 - 0.063 12.9 0.0 0.19 11.4 0.0 1.8 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) FNIP_C PF14638.6 ACT01361.1 - 0.066 12.8 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 Folliculin-interacting protein C-terminus Nod_GRP PF07806.11 ACT01361.1 - 5.7 6.9 7.9 4.5 7.2 2.4 2.5 2 0 0 2 2 2 0 Nodule-specific GRP repeat NUDIX PF00293.28 ACT01362.1 - 1.8e-06 28.0 0.1 2e-06 27.9 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain DinB_2 PF12867.7 ACT01363.1 - 6.4e-08 33.2 0.0 8.6e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 DinB superfamily DUF1706 PF08020.11 ACT01363.1 - 2.7e-05 24.1 1.6 0.00079 19.4 0.2 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1706) Pentapeptide_4 PF13599.6 ACT01364.1 - 1e-16 60.8 0.7 6.3e-08 32.7 0.1 2.9 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 ACT01364.1 - 4.4e-15 55.0 3.1 2.9e-06 26.8 3.2 4.0 2 1 1 4 4 4 4 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 ACT01364.1 - 3.1e-07 30.4 0.0 0.00019 21.5 0.1 2.8 3 0 0 3 3 3 2 Pentapeptide repeats (9 copies) DUF3737 PF12541.8 ACT01364.1 - 0.0062 15.8 0.8 0.0084 15.4 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3737) Glyoxalase PF00903.25 ACT01365.1 - 0.069 13.3 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 ACT01366.1 - 4.4e-06 26.9 0.0 1.8e-05 24.9 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ACT01366.1 - 0.00026 20.9 0.0 0.002 18.0 0.0 1.9 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 ACT01367.1 - 0.013 15.7 0.0 0.15 12.2 0.0 2.0 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily WG_beta_rep PF14903.6 ACT01369.1 - 4.4e-39 132.4 20.4 2.2e-08 34.3 0.1 8.5 9 0 0 9 9 9 6 WG containing repeat DUF3298 PF11738.8 ACT01369.1 - 7.2e-19 68.6 2.4 3.1e-18 66.6 2.4 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3298) PdaC PF13739.6 ACT01369.1 - 3.6e-05 24.7 0.8 0.00019 22.4 0.3 2.4 2 1 0 2 2 2 1 Deacetylase PdaC DEAD_assoc PF08494.11 ACT01371.1 - 1e-46 159.2 0.0 2.2e-46 158.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/H associated DEAD PF00270.29 ACT01371.1 - 1.1e-29 103.4 0.0 1.9e-28 99.4 0.0 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ACT01371.1 - 1e-16 61.3 0.0 4.1e-16 59.3 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT01371.1 - 1.9e-07 31.2 0.0 4.5e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 ACT01371.1 - 0.037 13.5 0.1 0.076 12.5 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.6 ACT01371.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_membrane PF00664.23 ACT01372.1 - 6.9e-50 170.2 9.7 1.1e-49 169.6 9.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT01372.1 - 1.5e-32 113.0 0.0 2.5e-32 112.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT01372.1 - 4.8e-06 26.2 0.1 0.00087 18.8 0.1 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ACT01372.1 - 0.00037 20.4 0.1 0.0018 18.2 0.0 2.0 1 1 1 2 2 2 1 RsgA GTPase DUF87 PF01935.17 ACT01372.1 - 0.0016 18.6 1.0 0.0058 16.8 0.2 2.1 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_29 PF13555.6 ACT01372.1 - 0.0061 16.3 0.2 0.017 14.9 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT01372.1 - 0.0065 16.9 0.2 0.024 15.0 0.2 2.0 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 ACT01372.1 - 0.024 13.9 0.0 0.05 12.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 ACT01372.1 - 0.032 13.9 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACT01372.1 - 0.033 14.3 0.0 0.17 11.9 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase NTPase_1 PF03266.15 ACT01372.1 - 0.057 13.3 0.2 0.44 10.4 0.1 2.2 1 1 1 2 2 2 0 NTPase NB-ARC PF00931.22 ACT01372.1 - 0.058 12.6 0.0 1.1 8.3 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain DEAD PF00270.29 ACT01372.1 - 0.13 12.0 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 ACT01372.1 - 0.17 12.2 0.0 0.41 10.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain ABC_membrane PF00664.23 ACT01373.1 - 4.9e-55 187.1 14.5 6.4e-55 186.7 14.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT01373.1 - 1.2e-33 116.5 0.0 2.5e-33 115.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01373.1 - 1.4e-06 28.3 0.3 0.0031 17.4 0.0 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 ACT01373.1 - 8e-06 26.3 0.6 0.0002 21.8 0.6 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_membrane_3 PF13748.6 ACT01373.1 - 8.4e-06 25.2 13.3 6e-05 22.4 0.4 3.1 4 0 0 4 4 4 2 ABC transporter transmembrane region AAA_22 PF13401.6 ACT01373.1 - 1.4e-05 25.4 0.4 0.00023 21.4 0.4 2.4 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 ACT01373.1 - 6.5e-05 22.5 0.6 0.0095 15.4 0.1 2.5 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 ACT01373.1 - 0.0057 16.4 0.5 0.021 14.5 0.5 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT01373.1 - 0.0058 17.0 1.2 0.018 15.5 0.5 2.2 2 1 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 ACT01373.1 - 0.0082 15.4 0.2 0.019 14.2 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin RsgA_GTPase PF03193.16 ACT01373.1 - 0.013 15.4 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 ACT01373.1 - 0.018 15.6 0.0 0.034 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 ACT01373.1 - 0.027 14.1 0.1 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 ACT01373.1 - 0.028 14.0 0.3 0.58 9.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ACT01373.1 - 0.029 14.1 0.3 0.078 12.7 0.3 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_membrane_2 PF06472.15 ACT01373.1 - 0.031 13.7 1.1 0.09 12.2 1.1 1.7 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 AAA_10 PF12846.7 ACT01373.1 - 0.051 12.5 0.0 0.086 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_15 PF13175.6 ACT01373.1 - 0.074 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 ACT01373.1 - 0.081 13.5 0.0 0.2 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACT01373.1 - 0.11 12.5 0.2 0.28 11.3 0.1 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_5 PF07728.14 ACT01373.1 - 0.13 12.3 0.4 1.2 9.2 0.4 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 ACT01373.1 - 0.13 12.5 0.1 0.37 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain Cu_amine_oxidN1 PF07833.11 ACT01374.1 - 6.8e-33 113.0 2.0 2.1e-24 85.8 0.3 2.2 1 1 1 2 2 2 2 Copper amine oxidase N-terminal domain Glyco_hydro_18 PF00704.28 ACT01374.1 - 1.3e-17 64.5 0.5 8.1e-15 55.3 0.2 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 18 DUF2642 PF10842.8 ACT01375.1 - 0.00039 20.2 0.5 0.00047 20.0 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2642) SPASM PF13186.6 ACT01377.1 - 2.4e-12 47.2 0.3 6e-12 45.9 0.3 1.7 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Radical_SAM PF04055.21 ACT01377.1 - 1.3e-11 45.2 0.0 2e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 ACT01377.1 - 0.00024 21.2 0.1 0.00057 20.0 0.0 1.6 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 ACT01377.1 - 0.016 15.5 0.2 0.05 13.9 0.1 1.8 1 1 1 2 2 2 0 4Fe-4S single cluster domain Gypsy PF07253.11 ACT01377.1 - 0.13 10.8 0.1 0.17 10.4 0.1 1.1 1 0 0 1 1 1 0 Gypsy protein Voltage_CLC PF00654.20 ACT01378.1 - 1e-62 212.4 39.8 1e-61 209.1 34.5 2.0 1 1 1 2 2 2 2 Voltage gated chloride channel DUF1072 PF06380.11 ACT01378.1 - 0.5 10.3 2.9 0.76 9.7 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) Acetyltransf_1 PF00583.25 ACT01379.1 - 3.6e-11 43.3 0.0 5.6e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT01379.1 - 1e-08 35.5 0.0 6.3e-08 32.9 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT01379.1 - 0.0013 18.6 0.0 0.027 14.4 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACT01379.1 - 0.0019 18.3 0.1 0.0054 16.8 0.0 1.8 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 ACT01379.1 - 0.0044 17.2 0.0 0.0057 16.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACT01379.1 - 0.075 13.7 0.0 0.1 13.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Peptidase_M42 PF05343.14 ACT01380.1 - 2.9e-76 256.3 0.1 3.3e-76 256.1 0.1 1.0 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase Peptidase_M20 PF01546.28 ACT01380.1 - 3.7e-07 30.1 0.0 1.1e-06 28.5 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 ACT01380.1 - 0.011 15.5 0.0 0.42 10.3 0.0 2.3 2 0 0 2 2 2 0 Peptidase family M28 HATPase_c PF02518.26 ACT01381.1 - 1.7e-20 73.6 0.1 2.7e-20 72.9 0.1 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT01381.1 - 6.7e-07 29.2 0.0 2e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 ACT01381.1 - 6.5e-06 26.0 0.0 1.1e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT01381.1 - 0.0023 17.9 0.0 0.0039 17.1 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HisKA_7TM PF16927.5 ACT01381.1 - 0.0027 17.8 19.7 0.0072 16.4 19.7 1.7 1 1 0 1 1 1 1 N-terminal 7TM region of histidine kinase Phage_holin_3_6 PF07332.11 ACT01381.1 - 0.1 12.6 0.1 0.1 12.6 0.1 3.2 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III ER_lumen_recept PF00810.18 ACT01381.1 - 0.13 13.1 3.4 0.21 12.4 2.9 1.6 1 1 0 1 1 1 0 ER lumen protein retaining receptor AA_permease_2 PF13520.6 ACT01381.1 - 0.28 10.0 13.5 0.028 13.3 7.1 2.1 1 1 0 2 2 2 0 Amino acid permease FtsK_4TM PF13491.6 ACT01381.1 - 3 7.5 7.9 0.51 10.0 2.3 2.3 2 0 0 2 2 2 0 4TM region of DNA translocase FtsK/SpoIIIE DUF2231 PF09990.9 ACT01381.1 - 5.4 7.5 6.0 34 4.9 1.1 3.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2231) Acyl_transf_3 PF01757.22 ACT01381.1 - 5.5 5.9 16.3 37 3.2 16.3 1.9 1 1 0 1 1 1 0 Acyltransferase family Response_reg PF00072.24 ACT01382.1 - 6.3e-18 65.0 0.2 1.3e-17 63.9 0.2 1.6 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 ACT01382.1 - 7.6e-08 31.8 0.7 1.4e-07 30.9 0.7 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACT01382.1 - 0.00015 21.3 0.7 0.00035 20.2 0.7 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Phasin PF05597.11 ACT01382.1 - 0.002 18.1 1.6 0.0034 17.4 1.6 1.3 1 0 0 1 1 1 1 Poly(hydroxyalcanoate) granule associated protein (phasin) Tipalpha PF16753.5 ACT01382.1 - 0.0098 15.7 0.2 0.015 15.2 0.2 1.3 1 0 0 1 1 1 1 TNF-alpha-Inducing protein of Helicobacter DUF3933 PF13069.6 ACT01382.1 - 0.073 12.9 0.2 0.63 9.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3933) IF3_N PF05198.16 ACT01382.1 - 0.077 13.3 0.2 23 5.4 0.0 2.8 2 1 0 2 2 2 0 Translation initiation factor IF-3, N-terminal domain LAGLIDADG_3 PF14528.6 ACT01382.1 - 0.12 12.7 0.3 0.81 10.0 0.2 2.1 2 0 0 2 2 2 0 LAGLIDADG-like domain DoxX_3 PF13781.6 ACT01383.1 - 1.5e-26 93.0 9.6 2.5e-26 92.3 9.6 1.3 1 0 0 1 1 1 1 DoxX-like family DoxX_2 PF13564.6 ACT01383.1 - 0.9 9.7 7.7 2.8 8.1 7.7 1.8 1 1 0 1 1 1 0 DoxX-like family DUF4166 PF13761.6 ACT01384.1 - 1.1e-59 201.2 0.1 1.3e-59 201.0 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4166) P22_Cro PF14549.6 ACT01384.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 DNA-binding transcriptional regulator Cro HD PF01966.22 ACT01385.1 - 8.7e-26 90.5 0.0 1.6e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 HD domain HD_5 PF13487.6 ACT01385.1 - 7.1e-17 61.4 0.0 1.9e-16 60.0 0.0 1.8 2 0 0 2 2 2 1 HD domain HDOD PF08668.12 ACT01385.1 - 0.00017 21.1 0.0 0.00038 20.0 0.0 1.6 1 0 0 1 1 1 1 HDOD domain HD_3 PF13023.6 ACT01385.1 - 0.034 14.1 0.0 0.062 13.2 0.0 1.5 1 0 0 1 1 1 0 HD domain GGDEF PF00990.21 ACT01386.1 - 1.8e-39 135.1 0.5 2.6e-39 134.6 0.5 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Response_reg PF00072.24 ACT01386.1 - 3.8e-29 101.1 0.0 7.3e-29 100.2 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 ACT01387.1 - 1e-28 100.0 0.7 2.7e-28 98.7 0.7 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_2 PF13185.6 ACT01387.1 - 2.6e-20 73.1 0.0 4.1e-10 40.1 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF PF01590.26 ACT01387.1 - 2.8e-19 70.1 0.0 1.6e-08 35.2 0.0 2.5 2 0 0 2 2 2 2 GAF domain HisKA PF00512.25 ACT01387.1 - 4.4e-19 68.3 0.2 1.5e-18 66.5 0.2 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF_3 PF13492.6 ACT01387.1 - 5.9e-10 39.6 0.0 1.5e-06 28.6 0.0 3.0 2 1 0 2 2 2 2 GAF domain HPTransfase PF10090.9 ACT01387.1 - 0.0051 16.6 0.0 0.008 16.0 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphotransferase C-terminal domain HATPase_c_5 PF14501.6 ACT01387.1 - 0.0063 16.4 0.9 0.024 14.5 0.5 2.3 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.6 ACT01387.1 - 0.013 15.5 0.1 0.2 11.6 0.0 2.5 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain TPP_enzyme_N PF02776.18 ACT01388.1 - 1.1e-48 165.0 0.0 2.5e-46 157.4 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 ACT01388.1 - 1.2e-30 106.3 0.0 6.9e-30 103.9 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ACT01388.1 - 9.7e-29 99.9 0.0 4.4e-28 97.7 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain GDPD PF03009.17 ACT01389.1 - 2.2e-50 171.8 0.0 3.4e-50 171.2 0.0 1.3 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ACT01389.1 - 0.00025 21.4 0.1 0.027 14.9 0.2 2.4 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.19 ACT01389.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain MFS_1 PF07690.16 ACT01391.1 - 7.9e-50 169.7 57.7 7.5e-35 120.5 28.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01391.1 - 1.6e-36 126.2 36.2 1.9e-27 96.3 6.7 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 ACT01391.1 - 2e-09 36.8 11.2 1.2e-07 31.0 11.1 2.5 1 1 0 1 1 1 1 MFS_1 like family MFS_4 PF06779.14 ACT01391.1 - 1.2e-06 28.0 32.1 1.8e-06 27.5 32.1 1.2 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 ACT01391.1 - 2 6.6 8.4 1.7 6.8 0.3 2.9 2 2 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family GerA PF03323.13 ACT01392.1 - 4.3e-174 579.4 6.0 5.3e-174 579.1 6.0 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_GerAC PF05504.11 ACT01393.1 - 1.4e-35 122.9 0.4 2.5e-35 122.1 0.4 1.4 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal DUF4743 PF15916.5 ACT01393.1 - 0.037 14.0 0.0 0.99 9.4 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4743) TctB PF07331.11 ACT01394.1 - 0.042 14.1 0.8 0.052 13.8 0.8 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family HupE_UreJ PF04955.12 ACT01394.1 - 0.09 12.2 0.5 0.11 12.0 0.5 1.1 1 0 0 1 1 1 0 HupE / UreJ protein Spore_permease PF03845.13 ACT01395.1 - 1.1e-51 175.6 37.1 1.5e-51 175.1 37.1 1.1 1 0 0 1 1 1 1 Spore germination protein ParBc PF02195.18 ACT01396.1 - 1.7e-21 76.3 0.8 3.3e-21 75.4 0.1 1.8 2 0 0 2 2 2 1 ParB-like nuclease domain DnaB_bind PF10410.9 ACT01396.1 - 0.1 12.8 0.4 2.5 8.3 0.1 2.5 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase DUF3306 PF11748.8 ACT01396.1 - 3.9 8.4 7.2 2.5 9.0 3.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3306) Epimerase PF01370.21 ACT01397.1 - 1.6e-19 70.3 0.0 2.8e-17 63.0 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ACT01397.1 - 1.2e-09 37.7 0.0 0.00014 21.1 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain NAD_binding_10 PF13460.6 ACT01397.1 - 4.4e-07 30.0 0.0 9.3e-07 28.9 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ACT01397.1 - 1.9e-06 27.5 0.1 0.00064 19.2 0.0 2.2 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ACT01397.1 - 0.0011 18.2 0.0 0.0022 17.2 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein NmrA PF05368.13 ACT01397.1 - 0.0028 17.2 0.0 0.013 15.1 0.0 1.9 1 1 0 1 1 1 1 NmrA-like family DUF1153 PF06627.11 ACT01397.1 - 0.05 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1153) AP_endonuc_2 PF01261.24 ACT01398.1 - 4.6e-12 45.8 0.0 1.7e-11 44.0 0.0 1.8 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel MFS_1 PF07690.16 ACT01399.1 - 3.8e-59 200.4 52.5 4.4e-58 196.9 50.3 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ACT01399.1 - 8.3e-19 67.4 18.9 8.3e-19 67.4 18.9 2.1 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ACT01399.1 - 2e-17 63.2 39.1 2.9e-14 52.8 15.3 2.8 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.6 ACT01399.1 - 0.00023 19.9 39.4 0.0021 16.7 7.2 3.5 2 1 0 3 3 3 2 MFS/sugar transport protein OATP PF03137.20 ACT01399.1 - 0.0026 16.1 8.7 0.0026 16.1 8.7 2.8 2 1 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family PadR PF03551.14 ACT01400.1 - 7e-12 45.1 0.0 1.2e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family Vir_act_alpha_C PF10400.9 ACT01400.1 - 0.0014 19.3 0.1 0.0031 18.2 0.1 1.6 1 0 0 1 1 1 1 Virulence activator alpha C-term AphA_like PF14557.6 ACT01400.1 - 0.0021 17.8 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 Putative AphA-like transcriptional regulator HTH_34 PF13601.6 ACT01400.1 - 0.0046 17.1 0.0 0.0091 16.2 0.0 1.5 1 1 0 1 1 1 1 Winged helix DNA-binding domain RTP PF02334.16 ACT01400.1 - 0.014 16.0 0.1 0.044 14.4 0.0 1.7 2 0 0 2 2 2 0 Replication terminator protein HTH_32 PF13565.6 ACT01400.1 - 0.065 13.9 0.0 0.27 11.9 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain Anp1 PF03452.14 ACT01400.1 - 0.15 11.4 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Anp1 Glucosaminidase PF01832.20 ACT01401.1 - 5.6e-15 55.6 0.3 9.6e-15 54.9 0.3 1.4 1 0 0 1 1 1 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase SH3_3 PF08239.11 ACT01401.1 - 1.1e-06 28.7 0.0 2.3e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.13 ACT01401.1 - 0.019 14.8 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain LysM PF01476.20 ACT01402.1 - 3.1e-07 30.3 0.3 1.1e-06 28.5 0.0 2.1 3 0 0 3 3 3 1 LysM domain VanW PF04294.13 ACT01404.1 - 1.1e-49 167.4 0.0 1.8e-49 166.7 0.0 1.4 1 0 0 1 1 1 1 VanW like protein PG_binding_4 PF12229.8 ACT01404.1 - 0.0019 18.4 0.0 0.0086 16.3 0.0 2.1 2 1 0 2 2 2 1 Putative peptidoglycan binding domain PD40 PF07676.12 ACT01405.1 - 1.2e-12 47.4 8.0 0.0016 18.3 0.0 6.6 6 1 1 7 7 7 3 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ACT01405.1 - 0.00023 20.1 0.9 0.45 9.2 0.1 3.0 2 1 1 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region rhaM PF05336.13 ACT01407.1 - 7.9e-23 80.6 0.4 8.8e-23 80.4 0.4 1.0 1 0 0 1 1 1 1 L-rhamnose mutarotase Malectin_like PF12819.7 ACT01407.1 - 0.01 15.0 0.1 0.011 15.0 0.1 1.1 1 0 0 1 1 1 0 Malectin-like domain Peptidase_M13 PF01431.21 ACT01407.1 - 0.014 15.0 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M13 zf-CHC2 PF01807.20 ACT01407.1 - 0.072 12.9 0.3 0.098 12.5 0.3 1.3 1 0 0 1 1 1 0 CHC2 zinc finger DivIVA PF05103.13 ACT01408.1 - 3.5e-13 49.8 3.0 3.8e-13 49.7 2.4 1.3 1 1 0 1 1 1 1 DivIVA protein Mcm10 PF09332.11 ACT01408.1 - 0.022 14.2 2.5 0.024 14.1 2.5 1.1 1 0 0 1 1 1 0 Mcm10 replication factor GerD PF17898.1 ACT01408.1 - 0.052 13.5 1.5 0.088 12.8 1.5 1.4 1 1 0 1 1 1 0 Spore germination GerD central core domain DUF2087 PF09860.9 ACT01408.1 - 0.067 13.4 0.4 0.72 10.0 0.0 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) DEAD PF00270.29 ACT01409.1 - 1.7e-47 161.5 0.1 4e-47 160.2 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ACT01409.1 - 3.7e-33 114.2 0.1 1.9e-30 105.5 0.0 2.9 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DbpA PF03880.15 ACT01409.1 - 1.1e-17 63.7 2.4 4.2e-17 61.9 2.2 2.1 2 0 0 2 2 2 1 DbpA RNA binding domain ResIII PF04851.15 ACT01409.1 - 1.8e-08 34.6 0.0 3.3e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ACT01409.1 - 0.00021 20.7 0.0 0.00048 19.5 0.0 1.6 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 ACT01409.1 - 0.00061 19.7 0.1 0.015 15.1 0.0 2.9 3 1 0 3 3 3 1 Helicase ERCC3_RAD25_C PF16203.5 ACT01409.1 - 0.03 13.5 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 ACT01409.1 - 0.072 13.4 0.3 0.31 11.3 0.1 2.1 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ACT01410.1 - 7.9e-56 188.4 0.2 7.3e-28 97.8 0.0 2.8 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACT01410.1 - 2.7e-17 63.5 0.8 0.00026 20.9 0.0 4.4 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT01410.1 - 8.9e-10 38.4 1.7 0.02 14.3 0.0 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT01410.1 - 4.4e-09 35.9 0.1 0.00013 21.7 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT01410.1 - 9.3e-09 35.4 0.0 7.4e-05 22.7 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ACT01410.1 - 9.5e-08 32.1 0.2 0.017 15.2 0.0 2.9 3 0 0 3 3 2 2 50S ribosome-binding GTPase ABC_tran_Xtn PF12848.7 ACT01410.1 - 1.2e-07 31.6 2.8 2.7e-07 30.5 2.8 1.6 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 ACT01410.1 - 3.7e-07 30.5 0.9 0.00044 20.5 0.0 3.5 3 1 0 3 3 2 1 AAA domain AAA_18 PF13238.6 ACT01410.1 - 3.3e-06 27.7 2.6 0.0016 19.0 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA_15 PF13175.6 ACT01410.1 - 4.1e-06 26.8 5.7 0.0041 16.9 0.0 3.9 3 1 0 4 4 4 2 AAA ATPase domain DLIC PF05783.11 ACT01410.1 - 7.8e-06 25.0 1.6 0.0051 15.7 0.0 3.1 3 0 0 3 3 3 1 Dynein light intermediate chain (DLIC) AAA_16 PF13191.6 ACT01410.1 - 3.6e-05 24.2 0.0 0.09 13.1 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 ACT01410.1 - 0.00015 21.6 0.0 0.019 14.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ACT01410.1 - 0.00029 21.0 1.8 0.049 13.8 0.0 3.2 3 1 0 3 3 3 1 AAA domain MeaB PF03308.16 ACT01410.1 - 0.00033 19.7 0.0 0.57 9.1 0.0 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 ACT01410.1 - 0.00043 20.9 16.6 0.0014 19.1 0.2 3.5 2 2 1 3 3 2 2 AAA domain NB-ARC PF00931.22 ACT01410.1 - 0.00047 19.4 0.8 0.78 8.9 0.0 3.3 2 1 1 3 3 3 2 NB-ARC domain Zeta_toxin PF06414.12 ACT01410.1 - 0.00085 18.7 0.0 1 8.6 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_27 PF13514.6 ACT01410.1 - 0.00085 19.0 0.0 0.18 11.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ACT01410.1 - 0.0014 19.0 0.1 0.87 10.0 0.0 3.3 4 1 0 4 4 2 1 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 ACT01410.1 - 0.0018 18.5 0.0 0.33 11.2 0.0 2.7 3 0 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase Rad17 PF03215.15 ACT01410.1 - 0.0022 18.0 0.0 0.034 14.1 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_7 PF12775.7 ACT01410.1 - 0.0033 17.0 0.0 0.4 10.2 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 ACT01410.1 - 0.004 16.9 0.1 0.37 10.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_13 PF13166.6 ACT01410.1 - 0.0048 15.6 5.9 0.23 10.1 0.0 3.5 3 1 1 4 4 4 1 AAA domain AAA_28 PF13521.6 ACT01410.1 - 0.0049 17.1 0.1 0.061 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 ACT01410.1 - 0.0059 16.2 0.2 0.12 12.0 0.0 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 ACT01410.1 - 0.0075 16.7 0.1 0.41 11.1 0.0 2.5 2 0 0 2 2 2 1 RNA helicase Arf PF00025.21 ACT01410.1 - 0.0095 15.4 0.0 0.29 10.6 0.0 2.6 2 0 0 2 2 2 1 ADP-ribosylation factor family Dynamin_N PF00350.23 ACT01410.1 - 0.011 15.8 4.1 0.73 9.9 0.1 2.9 3 0 0 3 3 3 0 Dynamin family NACHT PF05729.12 ACT01410.1 - 0.011 15.6 0.0 0.66 9.9 0.0 2.6 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 ACT01410.1 - 0.016 15.1 0.0 0.016 15.1 0.0 2.6 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 ACT01410.1 - 0.017 14.8 0.0 0.13 11.9 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 ACT01410.1 - 0.022 14.4 0.0 5.2 6.7 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 ACT01410.1 - 0.024 14.0 0.0 0.41 10.0 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family G-alpha PF00503.20 ACT01410.1 - 0.026 13.7 0.1 0.7 9.0 0.0 2.6 2 0 0 2 2 2 0 G-protein alpha subunit AAA_5 PF07728.14 ACT01410.1 - 0.026 14.5 0.7 1 9.4 0.0 2.9 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) FeoB_N PF02421.18 ACT01410.1 - 0.036 13.6 0.1 3.7 7.1 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B SRPRB PF09439.10 ACT01410.1 - 0.039 13.4 0.0 0.55 9.6 0.0 2.6 4 0 0 4 4 2 0 Signal recognition particle receptor beta subunit NTPase_1 PF03266.15 ACT01410.1 - 0.063 13.2 1.2 4.3 7.2 0.1 3.1 3 0 0 3 3 3 0 NTPase PduV-EutP PF10662.9 ACT01410.1 - 0.063 13.0 0.2 2.5 7.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 ACT01410.1 - 0.063 12.4 0.0 2.6 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_14 PF13173.6 ACT01410.1 - 0.07 13.2 0.0 1.6 8.8 0.0 3.0 4 0 0 4 4 2 0 AAA domain Sigma54_activat PF00158.26 ACT01410.1 - 0.16 11.7 0.4 3.9 7.1 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain DUF87 PF01935.17 ACT01410.1 - 0.43 10.6 7.1 5.5 7.0 0.1 3.5 2 1 1 3 3 3 0 Helicase HerA, central domain Beta-lactamase PF00144.24 ACT01411.1 - 1.3e-62 212.0 0.0 1.7e-62 211.6 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase PF00144.24 ACT01412.1 - 3.8e-51 174.3 0.0 5.5e-51 173.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 ACT01412.1 - 0.012 15.1 0.1 0.078 12.4 0.0 1.9 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase ABC2_membrane_6 PF06182.11 ACT01413.1 - 4.1e-25 88.9 16.3 5.5e-25 88.5 16.3 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_3 PF12698.7 ACT01413.1 - 2.4 7.2 21.5 0.27 10.3 15.4 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein ABC2_membrane PF01061.24 ACT01413.1 - 3.4 7.0 24.9 0.51 9.7 20.9 1.7 2 1 0 2 2 2 0 ABC-2 type transporter ABC2_membrane_6 PF06182.11 ACT01414.1 - 3.8e-35 121.7 10.1 4.7e-35 121.4 10.1 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 ACT01415.1 - 1.7e-23 83.7 0.0 2.7e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01415.1 - 1.3e-11 44.9 0.1 4.1e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT01415.1 - 0.00086 18.8 0.0 0.49 9.8 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT01415.1 - 0.00099 18.8 0.1 0.002 17.9 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT01415.1 - 0.0013 18.7 0.1 0.0034 17.3 0.0 1.6 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 ACT01415.1 - 0.0073 16.8 0.0 0.014 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 ACT01415.1 - 0.0076 16.2 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_27 PF13514.6 ACT01415.1 - 0.048 13.2 0.0 0.11 12.1 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ACT01415.1 - 0.068 12.9 0.3 0.2 11.3 0.2 1.8 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ACT01415.1 - 0.21 11.3 0.0 0.61 9.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain mono-CXXC PF15626.6 ACT01416.1 - 0.23 11.9 2.6 0.26 11.7 2.6 1.1 1 0 0 1 1 1 0 single CXXC unit TipAS PF07739.13 ACT01417.1 - 1.9e-34 118.7 3.0 3.9e-34 117.7 3.0 1.5 1 0 0 1 1 1 1 TipAS antibiotic-recognition domain MerR_1 PF13411.6 ACT01417.1 - 2.6e-17 62.7 0.3 6.8e-17 61.3 0.3 1.7 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT01417.1 - 6.7e-12 45.0 1.5 1.4e-11 44.0 0.9 1.9 2 0 0 2 2 2 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT01417.1 - 0.0001 22.8 6.7 0.00024 21.6 4.7 2.3 2 0 0 2 2 2 1 MerR, DNA binding TetR_C_24 PF17932.1 ACT01417.1 - 0.011 15.9 0.3 0.81 10.0 0.0 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain CHASE3 PF05227.13 ACT01417.1 - 0.081 12.8 2.9 0.17 11.8 1.8 2.0 1 1 1 2 2 2 0 CHASE3 domain RPA_interact_N PF14766.6 ACT01417.1 - 0.12 12.0 1.7 0.27 10.9 1.7 1.5 1 0 0 1 1 1 0 Replication protein A interacting N-terminal Acyl-CoA_dh_1 PF00441.24 ACT01418.1 - 5.8e-36 124.0 6.5 9.5e-36 123.3 4.9 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ACT01418.1 - 2.2e-25 89.5 0.1 5.1e-25 88.3 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ACT01418.1 - 2e-20 73.4 5.1 2e-20 73.4 5.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ACT01418.1 - 9.4e-06 25.7 0.0 2.3e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain SEF14_adhesin PF06443.11 ACT01418.1 - 0.037 13.9 0.2 0.093 12.6 0.2 1.6 1 0 0 1 1 1 0 SEF14-like adhesin Thiolase_N PF00108.23 ACT01419.1 - 3e-94 315.2 2.1 3.2e-94 315.1 0.9 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ACT01419.1 - 2.7e-46 156.2 1.9 7.3e-46 154.8 1.4 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ACT01419.1 - 1e-06 28.5 1.9 8.1e-06 25.6 0.6 2.2 1 1 1 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 ACT01419.1 - 0.00017 21.3 1.5 0.0022 17.8 0.1 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III UPF0175 PF03683.13 ACT01419.1 - 0.03 14.0 0.1 11 5.8 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0175) 3HCDH_N PF02737.18 ACT01420.1 - 4.4e-65 218.9 1.2 5.8e-65 218.5 1.2 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ACT01420.1 - 5.3e-39 132.7 0.2 8.3e-37 125.7 0.0 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ACT01420.1 - 7e-05 23.1 0.4 0.00015 21.9 0.4 1.7 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 ACT01420.1 - 0.00039 20.4 0.7 0.0017 18.4 0.6 2.0 1 1 1 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 ACT01420.1 - 0.00098 19.7 1.6 0.013 16.1 1.6 2.3 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_2 PF07992.14 ACT01420.1 - 0.0093 15.2 0.1 0.012 14.9 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 ACT01420.1 - 0.013 14.9 0.4 0.023 14.0 0.3 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 ACT01420.1 - 0.038 13.6 0.1 0.062 12.9 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA XdhC_C PF13478.6 ACT01420.1 - 0.039 14.4 0.0 0.07 13.6 0.0 1.4 1 0 0 1 1 1 0 XdhC Rossmann domain DFP PF04127.15 ACT01420.1 - 0.056 13.3 0.1 0.082 12.7 0.1 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein DGOK PF05035.12 ACT01420.1 - 0.082 11.8 0.5 0.14 11.0 0.5 1.4 1 0 0 1 1 1 0 2-keto-3-deoxy-galactonokinase Shikimate_DH PF01488.20 ACT01420.1 - 0.091 12.8 0.1 0.22 11.6 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.6 ACT01420.1 - 0.11 11.6 0.2 0.16 11.1 0.2 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Acyl-CoA_dh_1 PF00441.24 ACT01421.1 - 4.2e-35 121.2 0.3 9.5e-35 120.0 0.3 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ACT01421.1 - 1.8e-33 115.5 0.1 4.5e-33 114.3 0.1 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ACT01421.1 - 5e-28 97.1 0.0 9.5e-28 96.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ACT01421.1 - 1.8e-18 67.1 2.3 7.3e-18 65.1 2.3 2.0 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Amidohydro_2 PF04909.14 ACT01421.1 - 0.016 15.0 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Amidohydrolase PEP_mutase PF13714.6 ACT01422.1 - 1.3e-51 175.4 4.8 1.5e-51 175.1 4.8 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 ACT01422.1 - 2.8e-12 45.9 0.2 3.7e-12 45.5 0.2 1.1 1 0 0 1 1 1 1 Isocitrate lyase family Pantoate_transf PF02548.15 ACT01422.1 - 0.00073 19.0 0.5 0.039 13.4 0.3 2.1 1 1 1 2 2 2 2 Ketopantoate hydroxymethyltransferase HMGL-like PF00682.19 ACT01422.1 - 0.023 14.2 0.3 0.1 12.1 0.2 1.9 2 0 0 2 2 2 0 HMGL-like DDE_Tnp_1 PF01609.21 ACT01422.1 - 0.044 13.4 0.0 0.36 10.4 0.0 1.9 2 0 0 2 2 2 0 Transposase DDE domain Citrate_synt PF00285.21 ACT01423.1 - 2.3e-117 392.1 0.0 2.6e-117 391.9 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain MmgE_PrpD PF03972.14 ACT01424.1 - 1.3e-149 498.5 0.2 1.6e-149 498.2 0.2 1.0 1 0 0 1 1 1 1 MmgE/PrpD family ABC_tran PF00005.27 ACT01425.1 - 4.7e-50 169.7 2.8 6.5e-27 94.7 0.0 3.1 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 ACT01425.1 - 1.2e-21 76.5 6.3 2.5e-21 75.5 6.3 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01425.1 - 2.3e-16 60.5 1.0 0.0018 18.2 0.1 4.2 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT01425.1 - 1.8e-10 40.6 9.9 0.00022 20.7 1.0 4.4 3 2 0 4 4 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ACT01425.1 - 2.9e-06 27.3 0.5 0.15 12.1 0.1 3.3 3 1 0 3 3 3 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ACT01425.1 - 4.5e-06 26.7 0.1 0.13 12.2 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase NACHT PF05729.12 ACT01425.1 - 5.1e-06 26.5 0.2 0.0021 18.0 0.0 2.8 2 1 0 2 2 2 1 NACHT domain AAA_29 PF13555.6 ACT01425.1 - 1.5e-05 24.7 0.2 0.14 11.9 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain SbcCD_C PF13558.6 ACT01425.1 - 0.00017 21.8 0.1 6 7.2 0.1 4.1 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 ACT01425.1 - 0.00018 20.8 3.6 0.014 14.6 0.2 3.3 3 1 0 3 3 3 1 NB-ARC domain AAA_24 PF13479.6 ACT01425.1 - 0.00027 20.7 4.1 0.031 14.0 0.1 4.1 5 0 0 5 5 4 1 AAA domain RNA_helicase PF00910.22 ACT01425.1 - 0.0003 21.1 0.0 0.55 10.7 0.0 2.9 2 0 0 2 2 2 1 RNA helicase AAA_14 PF13173.6 ACT01425.1 - 0.00035 20.6 1.1 0.26 11.3 0.0 3.9 4 0 0 4 4 4 1 AAA domain AAA_16 PF13191.6 ACT01425.1 - 0.00071 20.0 0.0 0.027 14.9 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 ACT01425.1 - 0.0012 19.1 0.1 0.39 11.0 0.2 2.7 2 0 0 2 2 2 1 AAA domain ATP-synt_ab PF00006.25 ACT01425.1 - 0.0018 18.0 0.1 0.37 10.4 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_7 PF12775.7 ACT01425.1 - 0.0023 17.5 0.0 0.32 10.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Dynamin_N PF00350.23 ACT01425.1 - 0.0025 17.9 5.7 2.3 8.2 0.0 3.7 3 1 1 4 4 4 1 Dynamin family TrwB_AAD_bind PF10412.9 ACT01425.1 - 0.0026 16.7 0.6 0.36 9.7 0.1 2.5 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_33 PF13671.6 ACT01425.1 - 0.0027 17.9 0.1 0.27 11.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ACT01425.1 - 0.003 17.8 5.2 0.24 11.6 0.4 3.9 2 2 0 2 2 2 1 AAA domain TsaE PF02367.17 ACT01425.1 - 0.0047 16.9 0.1 0.69 9.9 0.0 2.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_15 PF13175.6 ACT01425.1 - 0.0048 16.7 15.0 0.67 9.6 0.0 4.6 3 1 0 3 3 3 1 AAA ATPase domain NTPase_1 PF03266.15 ACT01425.1 - 0.0051 16.7 0.5 2 8.3 0.2 2.9 3 0 0 3 3 2 1 NTPase AAA_23 PF13476.6 ACT01425.1 - 0.0054 17.3 12.5 0.34 11.4 0.0 3.4 3 1 0 3 3 3 2 AAA domain Roc PF08477.13 ACT01425.1 - 0.0071 16.6 0.1 0.41 10.9 0.0 3.0 3 0 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase AAA PF00004.29 ACT01425.1 - 0.0092 16.4 0.0 0.41 11.1 0.0 3.0 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 ACT01425.1 - 0.012 15.7 5.5 1.4 9.0 0.0 3.8 4 1 0 4 4 3 0 Helicase HerA, central domain T2SSE PF00437.20 ACT01425.1 - 0.012 14.7 0.0 0.4 9.7 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_25 PF13481.6 ACT01425.1 - 0.02 14.4 0.2 0.9 9.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 ACT01425.1 - 0.025 14.9 0.3 0.75 10.1 0.0 2.7 3 0 0 3 3 2 0 AAA domain MukB PF04310.12 ACT01425.1 - 0.033 14.0 0.1 1.3 8.8 0.0 2.6 2 0 0 2 2 2 0 MukB N-terminal FeoB_N PF02421.18 ACT01425.1 - 0.04 13.4 0.5 7.8 6.0 0.1 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B MobB PF03205.14 ACT01425.1 - 0.045 13.7 0.3 2.4 8.1 0.1 2.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 ACT01425.1 - 0.054 12.5 1.5 2 7.3 0.0 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RuvB_N PF05496.12 ACT01425.1 - 0.066 12.9 0.1 16 5.2 0.0 2.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain FtsK_SpoIIIE PF01580.18 ACT01425.1 - 0.081 12.3 6.3 2.5 7.4 0.0 3.5 3 1 1 4 4 4 0 FtsK/SpoIIIE family AAA_30 PF13604.6 ACT01425.1 - 0.096 12.4 1.4 9.6 5.9 0.6 3.2 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.22 ACT01425.1 - 0.12 12.0 0.5 2 8.0 0.1 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_5 PF07728.14 ACT01425.1 - 0.12 12.4 0.8 3.7 7.5 0.2 3.2 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ACT01425.1 - 0.14 11.8 1.3 13 5.5 0.1 3.8 4 0 0 4 4 4 0 IstB-like ATP binding protein DUF4446 PF14584.6 ACT01425.1 - 0.24 11.4 2.1 0.41 10.6 1.5 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF4446) Mg_chelatase PF01078.21 ACT01425.1 - 0.39 10.1 1.6 11 5.4 0.1 3.2 3 1 0 3 3 2 0 Magnesium chelatase, subunit ChlI MOSC PF03473.17 ACT01426.1 - 1.7e-18 66.9 0.0 2.3e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 ACT01426.1 - 4e-08 33.2 0.0 6e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain E1-E2_ATPase PF00122.20 ACT01427.1 - 1.5e-55 187.5 7.5 1.5e-55 187.5 7.5 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ACT01427.1 - 1.9e-45 155.7 4.8 1.9e-45 155.7 4.8 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ACT01427.1 - 2.8e-18 66.1 0.0 8.2e-18 64.6 0.0 1.9 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 ACT01427.1 - 3.9e-06 26.8 3.2 0.0051 16.6 0.7 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT01427.1 - 0.00024 21.6 0.2 0.0014 19.1 0.2 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 ACT01427.1 - 0.19 11.3 0.0 0.42 10.2 0.0 1.5 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Transcrip_reg PF01709.20 ACT01428.1 - 1.2e-81 273.7 2.0 1.3e-81 273.5 2.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator ALS_ss_C PF10369.9 ACT01428.1 - 0.07 13.3 0.4 0.18 12.1 0.4 1.7 1 0 0 1 1 1 0 Small subunit of acetolactate synthase NapD PF03927.13 ACT01428.1 - 0.45 10.6 2.7 0.38 10.8 0.4 2.0 2 0 0 2 2 2 0 NapD protein Aldo_ket_red PF00248.21 ACT01429.1 - 5.8e-78 262.1 0.0 6.5e-78 261.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Epimerase PF01370.21 ACT01430.1 - 4.4e-28 98.4 0.0 6.5e-28 97.8 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACT01430.1 - 1e-21 77.7 0.2 3.3e-17 62.9 0.2 3.0 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ACT01430.1 - 6.6e-12 45.0 0.0 9.7e-12 44.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ACT01430.1 - 8.3e-10 38.3 0.0 4.5e-07 29.3 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 ACT01430.1 - 2.5e-09 36.7 0.2 4.2e-05 22.8 0.6 3.1 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 ACT01430.1 - 1.9e-07 31.2 0.0 2.6e-07 30.7 0.0 1.3 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ACT01430.1 - 8.1e-06 25.1 0.0 1.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 ACT01430.1 - 0.00085 19.3 0.0 0.0017 18.3 0.0 1.6 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 ACT01430.1 - 0.0057 16.1 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 ACT01430.1 - 0.022 14.3 0.1 0.068 12.7 0.1 1.8 2 1 0 2 2 2 0 NmrA-like family EamA PF00892.20 ACT01431.1 - 8.5e-24 84.3 43.0 9.1e-13 48.6 20.2 2.0 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 ACT01431.1 - 7.2e-05 22.2 2.8 7.2e-05 22.2 2.8 2.3 1 1 2 3 3 3 1 Purine nucleobase transmembrane transport ATPase_gene1 PF09527.10 ACT01431.1 - 0.013 15.6 1.9 0.013 15.6 1.9 4.2 6 0 0 6 6 6 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter UPF0060 PF02694.15 ACT01431.1 - 0.15 12.3 12.9 1 9.6 2.2 3.0 2 1 0 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family VanZ PF04892.12 ACT01433.1 - 7.8e-25 88.0 10.2 9.2e-25 87.7 10.2 1.0 1 0 0 1 1 1 1 VanZ like family WTF PF03303.13 ACT01433.1 - 0.0064 16.2 5.3 0.0074 16.0 5.3 1.0 1 0 0 1 1 1 1 WTF protein KASH PF10541.9 ACT01433.1 - 0.6 10.4 4.9 9.9 6.5 0.4 2.3 2 0 0 2 2 2 0 Nuclear envelope localisation domain TetR_N PF00440.23 ACT01434.1 - 8e-17 60.8 0.2 1.4e-16 60.0 0.2 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_Tnp_1_2 PF13022.6 ACT01434.1 - 0.018 15.2 0.0 0.029 14.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase TetR_C_4 PF08359.11 ACT01434.1 - 0.044 13.9 0.1 0.1 12.7 0.1 1.7 1 1 0 1 1 1 0 YsiA-like protein, C-terminal region TetR_C_17 PF17922.1 ACT01434.1 - 0.051 13.7 0.0 0.12 12.5 0.0 1.6 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TetR_C_29 PF17938.1 ACT01434.1 - 0.095 12.8 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain MFS_1 PF07690.16 ACT01435.1 - 5.8e-57 193.2 45.2 5.8e-57 193.2 45.2 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01435.1 - 6e-14 51.7 28.2 5.4e-09 35.4 14.8 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter LacY_symp PF01306.19 ACT01435.1 - 6.7e-05 21.8 14.3 0.0039 16.0 0.6 2.6 3 0 0 3 3 3 2 LacY proton/sugar symporter MFS_2 PF13347.6 ACT01435.1 - 6.9e-05 21.6 32.5 0.00013 20.7 12.8 2.8 2 2 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 ACT01435.1 - 0.00015 20.8 20.4 0.02 13.8 2.5 2.5 2 1 0 2 2 2 2 MFS_1 like family MFS_3 PF05977.13 ACT01435.1 - 0.00024 19.7 5.1 0.00024 19.7 5.1 2.3 2 0 0 2 2 2 1 Transmembrane secretion effector PUCC PF03209.15 ACT01435.1 - 0.00099 18.2 4.9 0.00099 18.2 4.9 3.6 2 2 1 3 3 3 2 PUCC protein CM_2 PF01817.21 ACT01436.1 - 1.2e-18 67.2 1.6 1.4e-18 67.0 1.6 1.1 1 0 0 1 1 1 1 Chorismate mutase type II HHH_4 PF14490.6 ACT01436.1 - 0.051 13.6 0.1 0.086 12.8 0.1 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix containing domain Spore_permease PF03845.13 ACT01438.1 - 3.7e-50 170.6 32.8 4.9e-50 170.2 32.8 1.2 1 0 0 1 1 1 1 Spore germination protein GerA PF03323.13 ACT01439.1 - 3.1e-155 517.2 4.4 3.7e-155 516.9 4.4 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_GerAC PF05504.11 ACT01440.1 - 2.1e-35 122.4 0.0 4.9e-35 121.2 0.0 1.6 2 0 0 2 2 2 1 Spore germination B3/ GerAC like, C-terminal LysE PF01810.18 ACT01441.1 - 6.1e-27 94.3 19.4 7.6e-27 94.0 19.4 1.0 1 0 0 1 1 1 1 LysE type translocator DUF4307 PF14155.6 ACT01441.1 - 4.7 7.1 5.2 0.46 10.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) CAAD PF14159.6 ACT01441.1 - 7.6 6.4 8.8 1.8 8.5 4.7 2.1 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Aminotran_1_2 PF00155.21 ACT01442.1 - 6.7e-37 127.5 0.0 8e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II GntR PF00392.21 ACT01442.1 - 7.8e-19 67.1 0.0 1.6e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Aminotran_MocR PF12897.7 ACT01442.1 - 1e-11 44.3 0.0 1.5e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase HTH_Crp_2 PF13545.6 ACT01442.1 - 0.0031 17.4 0.0 0.016 15.2 0.0 2.3 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 ACT01442.1 - 0.018 15.4 0.0 0.05 13.9 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator Fe_dep_repress PF01325.19 ACT01442.1 - 0.029 14.6 0.0 0.11 12.7 0.0 2.0 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_11 PF08279.12 ACT01442.1 - 0.043 13.8 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 HTH domain MarR_2 PF12802.7 ACT01442.1 - 0.061 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 MarR family Acyl_transf_3 PF01757.22 ACT01443.1 - 1.5e-23 83.4 32.5 2.4e-23 82.8 32.5 1.3 1 0 0 1 1 1 1 Acyltransferase family Lipase_GDSL_2 PF13472.6 ACT01443.1 - 0.0015 19.0 0.1 0.005 17.2 0.1 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family DUF3530 PF12048.8 ACT01443.1 - 1.7 8.0 5.3 5.8 6.2 5.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3530) ORC6 PF05460.13 ACT01443.1 - 9.1 5.4 9.1 13 4.9 9.1 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Sigma70_r4_2 PF08281.12 ACT01444.1 - 1.1e-15 57.0 0.2 2.5e-15 55.8 0.2 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACT01444.1 - 4.4e-13 48.8 0.1 7.3e-13 48.1 0.1 1.4 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 ACT01444.1 - 3.9e-09 35.9 0.2 6.5e-09 35.2 0.2 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACT01444.1 - 0.00035 20.5 0.3 0.0005 20.0 0.3 1.5 1 1 0 1 1 1 1 ECF sigma factor DUF4835 PF16119.5 ACT01444.1 - 0.0018 17.4 0.7 0.015 14.5 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4835) HTH_30 PF13556.6 ACT01444.1 - 0.0032 17.3 0.1 0.006 16.4 0.1 1.4 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain S_2TMBeta PF18153.1 ACT01444.1 - 0.0072 16.1 0.3 0.012 15.5 0.3 1.3 1 0 0 1 1 1 1 SMODS-associating 2TM, beta-strand rich effector domain DUF3298 PF11738.8 ACT01445.1 - 8.2e-18 65.2 0.4 8.2e-18 65.2 0.4 2.3 3 1 0 3 3 3 1 Protein of unknown function (DUF3298) PdaC PF13739.6 ACT01445.1 - 6.3e-09 36.7 0.4 6.3e-09 36.7 0.4 2.2 2 1 0 2 2 2 1 Deacetylase PdaC DUF4179 PF13786.6 ACT01445.1 - 0.0059 17.0 2.8 0.012 16.0 2.7 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4179) Svf1_C PF17187.4 ACT01445.1 - 0.049 13.4 0.5 0.11 12.3 0.2 1.7 2 0 0 2 2 2 0 Svf1-like C-terminal lipocalin-like domain CAAD PF14159.6 ACT01445.1 - 0.14 12.0 0.7 0.3 11.0 0.7 1.4 1 0 0 1 1 1 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase adh_short PF00106.25 ACT01446.1 - 4.4e-47 160.1 0.0 5.5e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT01446.1 - 1.8e-28 99.7 0.0 2.2e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT01446.1 - 1.2e-12 48.1 0.0 1.8e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACT01446.1 - 0.00093 18.7 0.0 0.0014 18.1 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ACT01446.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding TrkA_N PF02254.18 ACT01446.1 - 0.019 15.2 0.0 0.032 14.5 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain RmlD_sub_bind PF04321.17 ACT01446.1 - 0.048 12.7 0.0 0.097 11.7 0.0 1.5 1 0 0 1 1 1 0 RmlD substrate binding domain Pyr_redox PF00070.27 ACT01446.1 - 0.16 12.5 0.1 0.48 11.0 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase YjcZ_2 PF09680.10 ACT01447.1 - 0.028 14.1 12.2 0.09 12.4 12.2 2.0 1 0 0 1 1 1 0 Family of unknown function YjcZ_2 PF09680.10 ACT01448.1 - 0.028 14.1 12.2 0.09 12.4 12.2 2.0 1 0 0 1 1 1 0 Family of unknown function BPD_transp_1 PF00528.22 ACT01449.1 - 8.9e-17 61.4 10.0 8.9e-17 61.4 10.0 1.5 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Vma12 PF11712.8 ACT01449.1 - 0.51 10.4 1.3 0.89 9.6 1.3 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase BPD_transp_1 PF00528.22 ACT01450.1 - 1.2e-15 57.7 8.7 1.2e-15 57.7 8.7 1.6 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 ACT01451.1 - 4.2e-34 118.0 0.1 5.6e-34 117.6 0.1 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT01451.1 - 4.4e-05 23.0 0.2 0.14 11.5 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT01451.1 - 8.2e-05 22.6 0.4 0.014 15.2 0.4 2.2 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ACT01451.1 - 8.2e-05 22.9 0.1 0.00016 22.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT01451.1 - 8.5e-05 22.5 0.2 0.00018 21.5 0.2 1.5 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 ACT01451.1 - 0.00072 19.6 0.2 0.002 18.2 0.1 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.6 ACT01451.1 - 0.00089 19.0 0.1 0.0013 18.5 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT01451.1 - 0.0022 17.7 0.1 0.0047 16.6 0.1 1.6 1 1 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT01451.1 - 0.0027 18.1 0.3 0.0066 16.9 0.3 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 ACT01451.1 - 0.0087 16.6 0.1 0.041 14.4 0.1 2.0 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ACT01451.1 - 0.0091 15.2 0.0 0.019 14.1 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain ABC_ATPase PF09818.9 ACT01451.1 - 0.011 14.6 0.8 0.89 8.3 0.1 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_23 PF13476.6 ACT01451.1 - 0.017 15.6 0.4 0.039 14.5 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ACT01451.1 - 0.026 14.7 0.2 0.045 13.9 0.2 1.8 1 1 0 1 1 1 0 AAA domain P2_N PF18628.1 ACT01451.1 - 0.029 14.1 0.1 8.2 6.2 0.0 2.3 2 0 0 2 2 2 0 Viral coat protein P2 N-terminal domain AAA_25 PF13481.6 ACT01451.1 - 0.051 13.2 0.0 0.24 11.0 0.0 2.1 3 0 0 3 3 3 0 AAA domain DUF4916 PF16262.5 ACT01451.1 - 0.063 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4916) AAA_15 PF13175.6 ACT01451.1 - 0.066 12.9 0.1 0.46 10.1 0.2 1.8 1 1 1 2 2 2 0 AAA ATPase domain cobW PF02492.19 ACT01451.1 - 0.075 12.6 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 ACT01451.1 - 0.094 12.8 0.2 2.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain G-alpha PF00503.20 ACT01451.1 - 0.12 11.6 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Phosphonate-bd PF12974.7 ACT01452.1 - 4.6e-67 226.1 1.5 5.4e-67 225.9 1.5 1.0 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1 PF09084.11 ACT01452.1 - 6.6e-12 45.8 0.6 5.4e-10 39.6 0.6 2.2 1 1 0 1 1 1 1 NMT1/THI5 like SBP_bac_3 PF00497.20 ACT01452.1 - 4.1e-10 39.5 0.2 2.7e-07 30.2 0.1 2.2 2 0 0 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 NMT1_2 PF13379.6 ACT01452.1 - 5.1e-05 23.1 0.8 8.9e-05 22.3 0.8 1.3 1 0 0 1 1 1 1 NMT1-like family NMT1_3 PF16868.5 ACT01452.1 - 0.0033 16.9 0.0 0.029 13.8 0.0 2.1 1 1 0 1 1 1 1 NMT1-like family Lipoprotein_9 PF03180.14 ACT01452.1 - 0.01 14.9 0.3 0.03 13.5 0.0 1.8 2 1 0 2 2 2 0 NLPA lipoprotein Mycoplasma_p37 PF06646.11 ACT01452.1 - 0.056 12.7 0.1 1.1 8.5 0.0 2.4 2 1 0 3 3 3 0 High affinity transport system protein p37 5_nucleotid_C PF02872.18 ACT01453.1 - 1.2e-29 103.5 0.0 2.2e-29 102.7 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 ACT01453.1 - 4.6e-11 43.6 0.1 7.5e-11 42.9 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACT01453.1 - 7.4e-05 23.0 0.0 0.0025 18.0 0.0 2.9 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain AA_permease_2 PF13520.6 ACT01454.1 - 1.6e-34 119.5 53.0 2.1e-34 119.1 53.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ACT01454.1 - 9.1e-34 116.9 48.8 1.5e-33 116.1 48.8 1.2 1 0 0 1 1 1 1 Amino acid permease DUF1989 PF09347.10 ACT01455.1 - 1.2e-47 161.6 0.0 1.5e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) DUF1989 PF09347.10 ACT01456.1 - 5.9e-56 188.7 0.0 7.3e-56 188.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) DHDPS PF00701.22 ACT01456.1 - 0.048 12.4 0.0 0.068 11.9 0.0 1.1 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family CT_A_B PF02626.15 ACT01457.1 - 7.6e-85 284.7 0.0 1.2e-84 284.1 0.0 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 ACT01457.1 - 3.7e-63 212.8 0.0 8e-63 211.7 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ACT01457.1 - 1.2e-45 154.6 0.0 2.2e-45 153.7 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain CT_C_D PF02682.16 ACT01457.1 - 3.8e-45 154.1 0.0 8.8e-45 152.9 0.0 1.6 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_C PF02785.19 ACT01457.1 - 4.1e-29 100.9 0.0 1e-28 99.6 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ACT01457.1 - 1.1e-16 60.4 0.4 2.3e-16 59.4 0.4 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ACT01457.1 - 1.3e-09 37.9 0.0 2.5e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 ACT01457.1 - 1.2e-08 34.7 1.7 0.00066 19.5 0.2 3.0 2 1 1 3 3 3 2 Biotin-lipoyl like ATP-grasp PF02222.22 ACT01457.1 - 1.6e-06 27.8 0.0 7.8e-06 25.6 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 ACT01457.1 - 0.00028 20.6 0.0 0.00051 19.7 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 ACT01457.1 - 0.00047 20.2 0.0 0.00077 19.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.6 ACT01457.1 - 0.0018 18.9 0.1 0.066 13.9 0.0 3.1 3 0 0 3 3 3 1 HlyD family secretion protein HlyD_D23 PF16576.5 ACT01457.1 - 0.0079 15.4 0.0 2.4 7.3 0.0 2.5 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_5 PF13549.6 ACT01457.1 - 0.014 14.8 0.0 0.034 13.6 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_4 PF13535.6 ACT01457.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain PTS_EIIA_1 PF00358.20 ACT01457.1 - 0.17 11.7 0.0 4.2 7.2 0.0 2.3 1 1 1 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Amidase PF01425.21 ACT01458.1 - 4.4e-75 253.4 0.0 9.6e-75 252.2 0.0 1.5 1 1 0 1 1 1 1 Amidase AAA_33 PF13671.6 ACT01459.1 - 3.9e-10 40.0 0.0 5.4e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ACT01459.1 - 3.8e-07 30.7 0.0 6.7e-07 29.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain Guanylate_kin PF00625.21 ACT01459.1 - 0.0022 17.7 0.1 0.038 13.7 0.0 2.2 2 0 0 2 2 2 1 Guanylate kinase AAA_14 PF13173.6 ACT01459.1 - 0.0035 17.4 0.0 0.0051 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACT01459.1 - 0.0039 17.5 0.0 0.005 17.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT01459.1 - 0.0047 17.3 0.0 0.0062 16.9 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 ACT01459.1 - 0.0075 16.6 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 RNA helicase ATPase_2 PF01637.18 ACT01459.1 - 0.011 15.6 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 ACT01459.1 - 0.013 15.9 0.0 0.018 15.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 ACT01459.1 - 0.015 14.9 0.1 4.6 6.8 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 ACT01459.1 - 0.019 14.7 0.0 0.05 13.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 ACT01459.1 - 0.019 14.7 0.1 0.12 12.0 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase NTPase_1 PF03266.15 ACT01459.1 - 0.027 14.4 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 NTPase KTI12 PF08433.10 ACT01459.1 - 0.043 13.3 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Hpr_kinase_C PF07475.12 ACT01459.1 - 0.049 13.2 0.0 0.26 10.8 0.0 1.9 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_28 PF13521.6 ACT01459.1 - 0.052 13.8 0.0 0.1 12.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain ParA PF10609.9 ACT01459.1 - 0.064 12.7 0.1 0.097 12.1 0.1 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase NACHT PF05729.12 ACT01459.1 - 0.068 13.1 0.0 0.12 12.3 0.0 1.5 1 1 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 ACT01459.1 - 0.068 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 ACT01459.1 - 0.09 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 ACT01459.1 - 0.097 13.1 0.0 0.22 12.0 0.0 1.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 ACT01459.1 - 0.1 11.7 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Rad17 PF03215.15 ACT01459.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain DinB_2 PF12867.7 ACT01460.1 - 2.8e-10 40.8 0.2 4.2e-10 40.2 0.2 1.2 1 0 0 1 1 1 1 DinB superfamily DUF1569 PF07606.11 ACT01460.1 - 6.1e-05 23.1 1.4 0.0013 18.8 1.4 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1569) DinB PF05163.12 ACT01460.1 - 0.0062 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 DinB family Imm5 PF14423.6 ACT01461.1 - 0.0055 17.0 0.4 0.0067 16.7 0.4 1.1 1 0 0 1 1 1 1 Immunity protein Imm5 FAM199X PF15814.5 ACT01461.1 - 0.059 12.4 5.5 0.068 12.2 5.5 1.1 1 0 0 1 1 1 0 Protein family FAM199X MOSC PF03473.17 ACT01462.1 - 1.5e-18 67.0 0.0 2.1e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 ACT01462.1 - 1.7e-10 40.8 0.0 2.7e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Na_H_Exchanger PF00999.21 ACT01463.1 - 1.9e-63 214.5 49.4 2.3e-63 214.3 49.4 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TspO_MBR PF03073.15 ACT01463.1 - 0.0071 16.4 6.3 0.0071 16.4 6.3 3.3 3 2 0 3 3 3 1 TspO/MBR family DUF2277 PF10041.9 ACT01463.1 - 0.14 12.5 0.3 0.31 11.4 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2277) FMN_red PF03358.15 ACT01464.1 - 1.4e-31 109.4 0.0 1.9e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ACT01464.1 - 0.00075 19.3 0.0 0.001 18.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Acetyltransf_3 PF13302.7 ACT01465.1 - 3.3e-22 79.6 0.0 4.5e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACT01465.1 - 2.4e-12 47.3 0.0 2.7e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT01465.1 - 5.2e-10 39.6 0.1 7.3e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 ACT01465.1 - 2.5e-07 30.5 0.0 3.9e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT01465.1 - 0.00015 21.6 0.1 0.00031 20.7 0.1 1.6 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ACT01465.1 - 0.014 15.3 0.5 0.02 14.8 0.5 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PBP_like PF12727.7 ACT01466.1 - 2.2e-54 183.5 0.0 3e-54 183.1 0.0 1.1 1 0 0 1 1 1 1 PBP superfamily domain HTH_17 PF12728.7 ACT01466.1 - 8.7e-15 54.6 0.1 1.7e-14 53.7 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain SBP_bac_11 PF13531.6 ACT01466.1 - 7.8e-05 22.5 0.0 0.00012 21.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Phosphonate-bd PF12974.7 ACT01466.1 - 0.038 13.6 0.0 0.053 13.1 0.0 1.2 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein HTH_23 PF13384.6 ACT01466.1 - 0.052 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_22 PF13309.6 ACT01466.1 - 0.073 13.2 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 HTH domain LysR_substrate PF03466.20 ACT01466.1 - 0.085 12.2 0.0 1.5 8.2 0.0 2.1 1 1 1 2 2 2 0 LysR substrate binding domain SBP_bac_11 PF13531.6 ACT01467.1 - 1.6e-47 162.2 4.2 2e-47 161.9 4.2 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT01467.1 - 9.4e-24 84.9 9.0 3.6e-23 83.0 9.0 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein Carot_N PF09150.10 ACT01467.1 - 0.0065 16.4 0.2 0.012 15.5 0.2 1.4 1 0 0 1 1 1 1 Orange carotenoid protein, N-terminal SBP_bac_6 PF13343.6 ACT01467.1 - 0.0097 15.3 0.2 0.11 11.9 0.1 2.3 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein PBP_like_2 PF12849.7 ACT01467.1 - 0.016 14.9 9.6 0.22 11.2 9.6 2.3 1 1 0 1 1 1 0 PBP superfamily domain Blt1 PF12754.7 ACT01467.1 - 2.7 8.3 5.8 3.9 7.8 1.1 2.6 3 1 0 3 3 3 0 Blt1 N-terminal domain LPAM_1 PF08139.12 ACT01468.1 - 0.14 12.7 3.5 0.26 11.9 3.5 1.4 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site GerA PF03323.13 ACT01469.1 - 1.1e-164 548.3 3.0 1.4e-164 548.0 3.0 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein IF-2 PF11987.8 ACT01469.1 - 0.00044 20.3 0.5 0.0017 18.5 0.3 1.9 2 0 0 2 2 2 1 Translation-initiation factor 2 Spore_permease PF03845.13 ACT01470.1 - 2.1e-43 148.4 32.1 2.1e-43 148.4 32.1 1.3 2 0 0 2 2 2 1 Spore germination protein Spore_GerAC PF05504.11 ACT01471.1 - 9.2e-26 91.0 0.3 1.7e-25 90.1 0.3 1.5 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal LPAM_1 PF08139.12 ACT01471.1 - 1.3 9.7 2.9 3 8.5 2.9 1.7 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site EzrA PF06160.12 ACT01472.1 - 0.0039 15.4 10.0 0.0048 15.1 10.0 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA MUG113 PF13455.6 ACT01472.1 - 0.015 16.0 1.1 0.83 10.4 1.1 2.3 1 1 0 1 1 1 0 Meiotically up-regulated gene 113 FUSC PF04632.12 ACT01472.1 - 0.091 11.3 5.4 0.11 11.0 5.4 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family GvpL_GvpF PF06386.11 ACT01472.1 - 0.11 12.4 6.2 0.13 12.2 6.2 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Glyco_tranf_2_3 PF13641.6 ACT01472.1 - 0.11 12.4 1.1 0.13 12.1 1.1 1.1 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Cob_adeno_trans PF01923.18 ACT01472.1 - 0.14 12.3 4.7 0.16 12.1 4.7 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase 5_nucleotid PF05761.14 ACT01472.1 - 0.16 10.9 8.9 0.2 10.5 8.9 1.1 1 0 0 1 1 1 0 5' nucleotidase family GLTSCR1 PF15249.6 ACT01472.1 - 0.25 11.8 6.9 0.35 11.3 5.5 2.0 1 1 1 2 2 2 0 Conserved region of unknown function on GLTSCR protein FTCD_C PF04961.12 ACT01472.1 - 0.25 11.1 3.9 0.3 10.8 3.9 1.1 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Arfaptin PF06456.13 ACT01472.1 - 0.26 10.8 9.6 0.33 10.5 9.6 1.1 1 0 0 1 1 1 0 Arfaptin-like domain AIP3 PF03915.13 ACT01472.1 - 0.31 10.1 12.2 0.33 10.0 12.2 1.0 1 0 0 1 1 1 0 Actin interacting protein 3 DUF745 PF05335.13 ACT01472.1 - 0.39 10.4 21.0 1.9 8.2 21.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Tweety PF04906.13 ACT01472.1 - 0.6 8.7 10.4 0.76 8.4 10.4 1.1 1 0 0 1 1 1 0 Tweety FapA PF03961.13 ACT01472.1 - 0.61 8.6 6.6 0.62 8.6 6.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Cauli_DNA-bind PF03310.13 ACT01472.1 - 0.89 9.6 6.2 3.8 7.6 6.2 1.9 1 1 0 1 1 1 0 Caulimovirus DNA-binding protein DUF948 PF06103.11 ACT01472.1 - 0.92 9.8 7.9 1.7 9.0 4.0 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF2203 PF09969.9 ACT01472.1 - 2.9 8.6 9.1 4.5 8.0 9.0 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF3450 PF11932.8 ACT01472.1 - 3 7.1 19.6 3.8 6.8 19.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 ACT01472.1 - 3.6 7.7 24.6 1.1 9.3 21.5 1.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein CCDC74_C PF14917.6 ACT01472.1 - 3.8 8.1 18.5 1.3 9.5 9.2 2.5 1 1 2 3 3 3 0 Coiled coil protein 74, C terminal OmpH PF03938.14 ACT01472.1 - 4.3 7.7 20.4 6.2 7.2 20.4 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MAT1 PF06391.13 ACT01472.1 - 4.9 6.9 14.1 6.3 6.6 14.1 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 LMBR1 PF04791.16 ACT01472.1 - 5.1 5.9 8.8 5.9 5.7 8.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein MFS_1 PF07690.16 ACT01473.1 - 1.6e-53 181.9 55.1 6.1e-45 153.7 35.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01473.1 - 3.1e-06 26.3 8.8 3.1e-06 26.3 8.8 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 ACT01473.1 - 6.5e-06 24.8 15.5 0.00011 20.7 4.3 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector LacY_symp PF01306.19 ACT01473.1 - 3.7e-05 22.7 7.6 3.7e-05 22.7 7.6 2.1 1 1 1 2 2 2 1 LacY proton/sugar symporter OATP PF03137.20 ACT01473.1 - 0.13 10.5 11.8 0.2 9.9 0.7 3.2 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF2935 PF11155.8 ACT01474.1 - 7.7e-52 174.8 5.8 1.3e-26 93.3 0.3 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF2935) LPAM_1 PF08139.12 ACT01475.1 - 0.00092 19.6 4.8 0.002 18.5 4.8 1.5 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site DUF3127 PF11325.8 ACT01475.1 - 0.018 15.3 0.0 0.056 13.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3127) VCBS PF13517.6 ACT01475.1 - 0.032 14.8 0.0 0.082 13.5 0.0 1.7 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella LPAM_2 PF13627.6 ACT01475.1 - 0.42 10.5 4.3 0.7 9.8 4.3 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site AAA_21 PF13304.6 ACT01476.1 - 1.4e-19 71.1 1.1 1.7e-10 41.2 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ACT01476.1 - 9.7e-17 61.7 0.3 1.9e-08 34.4 0.1 2.1 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 ACT01476.1 - 5.7e-15 55.4 0.1 5.2e-07 29.3 0.1 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ACT01476.1 - 2.1e-09 38.2 0.0 3.4e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ACT01476.1 - 9.1e-07 29.5 0.0 7.8e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 ACT01476.1 - 3.3e-06 26.8 0.0 6.8e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.9 ACT01476.1 - 7.4e-05 21.7 0.0 0.00012 21.1 0.0 1.2 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_22 PF13401.6 ACT01476.1 - 0.0011 19.2 0.1 0.0084 16.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT01476.1 - 0.0048 17.3 0.1 0.0083 16.5 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ACT01476.1 - 0.0061 17.0 0.0 0.018 15.5 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ACT01476.1 - 0.0069 16.3 0.1 0.013 15.4 0.1 1.4 1 0 0 1 1 1 1 NACHT domain MeaB PF03308.16 ACT01476.1 - 0.011 14.7 0.0 0.016 14.2 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 ACT01476.1 - 0.012 15.5 0.0 0.018 14.9 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase DUF2813 PF11398.8 ACT01476.1 - 0.017 14.4 0.0 0.18 11.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) AAA_33 PF13671.6 ACT01476.1 - 0.057 13.6 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 ACT01476.1 - 0.08 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ACT01476.1 - 0.084 12.6 0.0 0.097 12.4 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ACT01476.1 - 0.086 12.8 0.0 0.37 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 ACT01476.1 - 0.096 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ACT01476.1 - 0.14 11.9 0.0 2.6 7.7 0.0 2.3 2 1 0 2 2 2 0 IstB-like ATP binding protein AAA_17 PF13207.6 ACT01476.1 - 0.14 12.6 0.1 2.4 8.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ACT01476.1 - 0.18 11.4 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain GrpB PF04229.14 ACT01477.1 - 3.3e-46 157.4 0.0 3.7e-46 157.2 0.0 1.0 1 0 0 1 1 1 1 GrpB protein NTP_transf_5 PF14907.6 ACT01477.1 - 0.02 14.5 0.0 0.22 11.1 0.0 2.0 1 1 1 2 2 2 0 Uncharacterised nucleotidyltransferase Chs7 PF12271.8 ACT01478.1 - 0.014 14.8 1.4 0.017 14.5 1.4 1.1 1 0 0 1 1 1 0 Chitin synthase export chaperone Peptidase_U4 PF03419.13 ACT01478.1 - 0.086 12.1 5.6 0.1 11.9 5.6 1.0 1 0 0 1 1 1 0 Sporulation factor SpoIIGA DUF2838 PF10998.8 ACT01478.1 - 0.19 12.0 3.4 0.32 11.2 3.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2838) DUF2070 PF09843.9 ACT01478.1 - 2.3 6.4 6.1 2.5 6.3 6.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HTH_1 PF00126.27 ACT01479.1 - 7.4e-18 64.3 0.0 1.3e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 ACT01479.1 - 2.1e-08 33.8 0.0 2.8e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_30 PF13556.6 ACT01479.1 - 0.00054 19.7 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain MarR_2 PF12802.7 ACT01479.1 - 0.0011 18.8 0.0 0.0023 17.8 0.0 1.5 1 0 0 1 1 1 1 MarR family MarR PF01047.22 ACT01479.1 - 0.0027 17.6 0.1 0.012 15.6 0.0 2.2 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.6 ACT01479.1 - 0.0089 15.6 0.0 0.022 14.3 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding DUF2089 PF09862.9 ACT01479.1 - 0.0091 16.0 0.1 0.032 14.3 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2089) Mga PF05043.13 ACT01479.1 - 0.016 15.8 1.9 0.08 13.5 0.1 2.8 3 0 0 3 3 3 0 Mga helix-turn-helix domain HTH_28 PF13518.6 ACT01479.1 - 0.018 15.2 0.0 0.038 14.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_11 PF08279.12 ACT01479.1 - 0.053 13.5 0.1 0.24 11.4 0.1 2.2 1 0 0 1 1 1 0 HTH domain Meth_synt_2 PF01717.18 ACT01480.1 - 1.4e-149 497.8 0.0 1.3e-146 488.0 0.0 2.5 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 ACT01480.1 - 2.9e-127 424.5 0.2 3.9e-118 394.5 0.0 2.8 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain Mac_assoc PF16628.5 ACT01480.1 - 0.086 13.0 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 Unstructured region on maltose acetyltransferase Sigma70_r2 PF04542.14 ACT01481.1 - 4.8e-13 48.7 0.1 1e-12 47.6 0.1 1.6 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT01481.1 - 6e-10 38.6 0.0 1.2e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT01481.1 - 1.5e-08 34.0 0.1 3.4e-08 32.9 0.1 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 ACT01481.1 - 0.00047 19.9 0.6 0.0012 18.5 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain DUF722 PF05263.11 ACT01481.1 - 0.015 15.5 0.1 0.021 15.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF722) HTH_37 PF13744.6 ACT01481.1 - 0.025 14.5 0.6 0.078 12.9 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_ECF PF07638.11 ACT01481.1 - 0.032 14.1 1.6 0.11 12.4 0.1 2.2 2 1 1 3 3 3 0 ECF sigma factor GerE PF00196.19 ACT01481.1 - 0.062 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family DUF2774 PF11242.8 ACT01481.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) DUF4179 PF13786.6 ACT01482.1 - 0.014 15.8 0.2 0.029 14.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) Phage_P2_GpU PF06995.11 ACT01482.1 - 0.09 12.4 0.0 0.28 10.8 0.0 1.7 2 0 0 2 2 2 0 Phage P2 GpU ABC_tran PF00005.27 ACT01483.1 - 4.1e-26 92.1 0.0 6.8e-26 91.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01483.1 - 3.7e-10 40.1 0.1 1.2e-05 25.3 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT01483.1 - 0.0021 17.8 0.0 0.0039 16.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACT01483.1 - 0.023 15.2 0.1 0.039 14.4 0.1 1.3 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 ACT01483.1 - 0.027 13.9 0.0 3.1 7.2 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain FlbD PF06289.11 ACT01483.1 - 0.095 12.3 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Flagellar and Swarming motility proteins RsgA_GTPase PF03193.16 ACT01483.1 - 0.15 12.0 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase ABC2_membrane_2 PF12679.7 ACT01484.1 - 8.1e-11 41.7 16.5 1.4e-10 40.9 16.5 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 ACT01484.1 - 0.25 11.3 14.6 0.74 9.7 14.5 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein Spore_GerAC PF05504.11 ACT01485.1 - 1.4e-23 83.9 0.2 2.8e-23 82.9 0.2 1.5 2 0 0 2 2 2 1 Spore germination B3/ GerAC like, C-terminal Spore_II_R PF09551.10 ACT01485.1 - 0.073 13.5 0.2 0.13 12.7 0.2 1.4 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) Filo_glycop PF01611.16 ACT01485.1 - 0.09 11.7 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Filovirus glycoprotein T3SS_needle_F PF09392.10 ACT01485.1 - 0.25 11.6 1.8 2.1 8.6 0.2 2.5 2 0 0 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Spore_permease PF03845.13 ACT01486.1 - 5.6e-46 156.8 29.2 7.2e-46 156.5 29.2 1.1 1 0 0 1 1 1 1 Spore germination protein NADH_oxidored PF08040.11 ACT01486.1 - 0.067 12.9 0.5 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 MNLL subunit GerA PF03323.13 ACT01487.1 - 1.9e-147 491.6 2.2 2.1e-147 491.4 2.2 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Glyco_hydro_1 PF00232.18 ACT01488.1 - 5.2e-146 486.6 1.2 5.8e-146 486.5 1.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 DUF420 PF04238.12 ACT01489.1 - 3.5e-43 147.0 14.2 4.6e-43 146.6 13.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF420) DUF2306 PF10067.9 ACT01489.1 - 0.00028 21.1 10.1 0.0047 17.1 1.6 2.4 2 1 0 2 2 2 2 Predicted membrane protein (DUF2306) TNFR_16_TM PF18422.1 ACT01489.1 - 0.2 11.6 0.1 0.2 11.6 0.1 4.2 4 0 0 4 4 4 0 Tumor necrosis factor receptor member 16 trans-membrane domain DUF2070 PF09843.9 ACT01489.1 - 0.43 8.8 12.4 0.49 8.6 12.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF202 PF02656.15 ACT01489.1 - 1.4 9.4 12.4 77 3.8 12.3 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF202) MerC PF03203.14 ACT01489.1 - 3.1 8.3 13.8 0.58 10.6 4.3 2.5 1 1 0 2 2 2 0 MerC mercury resistance protein DUF2393 PF09624.10 ACT01490.1 - 0.02 14.9 1.8 0.034 14.1 1.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2393) Arrestin_C PF02752.22 ACT01490.1 - 0.053 14.0 0.6 0.088 13.3 0.6 1.5 1 1 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain CBM_6 PF03422.15 ACT01491.1 - 4.2e-64 214.5 29.1 5.2e-19 68.8 1.1 5.7 6 0 0 6 6 6 4 Carbohydrate binding module (family 6) Glyco_hydro_43 PF04616.14 ACT01491.1 - 2.8e-42 145.0 2.2 5.7e-42 144.0 2.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF5010_C PF18099.1 ACT01491.1 - 1.9e-40 137.4 18.3 7e-12 45.5 0.6 5.5 5 0 0 5 5 5 4 DUF5010 C-terminal domain DUF1080 PF06439.11 ACT01491.1 - 5.6e-10 39.6 7.8 3.7e-08 33.7 0.8 3.7 4 0 0 4 4 4 2 Domain of Unknown Function (DUF1080) CBM_35 PF16990.5 ACT01491.1 - 9.4e-10 38.8 12.8 0.069 13.4 0.6 4.8 4 0 0 4 4 4 4 Carbohydrate binding module (family 35) Laminin_G_2 PF02210.24 ACT01491.1 - 0.0086 16.7 0.4 8.2 7.0 0.1 3.5 3 1 0 3 3 3 1 Laminin G domain Glyco_hydro_130 PF04041.13 ACT01491.1 - 0.011 14.7 0.1 1.7 7.5 0.0 2.3 2 0 0 2 2 2 0 beta-1,4-mannooligosaccharide phosphorylase Laminin_G_1 PF00054.23 ACT01491.1 - 0.012 15.8 0.0 0.79 9.9 0.0 2.8 2 0 0 2 2 2 0 Laminin G domain FlgD_ig PF13860.6 ACT01491.1 - 0.022 14.6 10.9 5.1 7.0 0.1 6.0 6 0 0 6 6 6 0 FlgD Ig-like domain DUF3247 PF11607.8 ACT01491.1 - 0.18 12.1 0.4 13 6.1 0.0 3.2 4 0 0 4 4 3 0 Protein of unknown function (DUF3247) Flagellin_D3 PF08884.11 ACT01491.1 - 0.78 10.2 5.2 2.5 8.5 0.2 3.8 3 0 0 3 3 3 0 Flagellin D3 domain MFS_1 PF07690.16 ACT01492.1 - 7.5e-40 136.9 56.5 9e-32 110.4 23.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01492.1 - 1.7e-08 33.8 14.2 1.7e-08 33.8 14.2 3.0 2 1 1 3 3 3 2 Sugar (and other) transporter Nuc_H_symport PF03825.16 ACT01492.1 - 1.2e-05 24.5 2.6 1.2e-05 24.5 2.6 2.4 1 1 1 2 2 2 1 Nucleoside H+ symporter MFS_1_like PF12832.7 ACT01492.1 - 7.4e-05 21.8 28.7 0.00015 20.8 10.0 2.1 1 1 1 2 2 2 2 MFS_1 like family MFS_4 PF06779.14 ACT01492.1 - 0.0026 17.1 34.3 0.0035 16.7 33.2 1.7 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB HTH_20 PF12840.7 ACT01493.1 - 6.7e-11 42.1 0.0 8.2e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 ACT01493.1 - 5.4e-09 35.8 0.6 8.5e-09 35.1 0.6 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family RP-C PF03428.13 ACT01493.1 - 0.037 13.7 0.0 0.039 13.6 0.0 1.3 1 1 0 1 1 1 0 Replication protein C N-terminal domain DUF4359 PF14271.6 ACT01494.1 - 0.029 15.1 0.2 2.6 8.9 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4359) Pilus_CpaD PF09476.10 ACT01495.1 - 0.15 11.7 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) Peripla_BP_3 PF13377.6 ACT01496.1 - 2.3e-33 115.9 0.0 5.1e-33 114.7 0.1 1.6 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT01496.1 - 5.3e-20 72.0 0.0 6.9e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT01496.1 - 5.4e-16 58.1 0.4 1.3e-15 56.9 0.4 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACT01496.1 - 8.3e-07 28.8 0.0 1.3e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_3 PF01381.22 ACT01496.1 - 0.001 19.1 1.8 0.012 15.7 0.0 3.2 3 0 0 3 3 3 1 Helix-turn-helix TetR_N PF00440.23 ACT01496.1 - 0.0022 17.8 0.0 0.0053 16.5 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_31 PF13560.6 ACT01496.1 - 0.019 15.3 0.0 0.14 12.6 0.0 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain SBP_bac_1 PF01547.25 ACT01497.1 - 2.2e-20 73.9 9.5 4.5e-20 72.8 9.5 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT01497.1 - 0.0051 16.6 0.0 0.044 13.5 0.0 2.2 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT01497.1 - 0.2 12.3 4.1 4.6 7.9 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3502) LPAM_1 PF08139.12 ACT01497.1 - 8.4 7.1 5.3 36 5.1 5.3 2.1 1 1 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site BPD_transp_1 PF00528.22 ACT01498.1 - 2e-11 44.0 20.3 2e-11 44.0 20.3 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component PHP_C PF13263.6 ACT01499.1 - 0.0029 17.3 0.1 0.024 14.4 0.2 2.5 2 1 0 2 2 2 1 PHP-associated PHP PF02811.19 ACT01499.1 - 0.021 15.1 0.1 0.031 14.6 0.1 1.3 1 0 0 1 1 1 0 PHP domain SinI PF08671.10 ACT01502.1 - 0.033 14.0 0.0 0.058 13.2 0.0 1.4 1 0 0 1 1 1 0 Anti-repressor SinI Plus-3 PF03126.18 ACT01502.1 - 0.097 13.2 0.1 0.1 13.2 0.1 1.1 1 0 0 1 1 1 0 Plus-3 domain Cass2 PF14526.6 ACT01503.1 - 2.2e-24 86.3 0.1 2.5e-24 86.1 0.1 1.0 1 0 0 1 1 1 1 Integron-associated effector binding protein Cass2 PF14526.6 ACT01504.1 - 0.0078 16.4 0.0 0.011 15.9 0.0 1.5 1 1 0 1 1 1 1 Integron-associated effector binding protein PEX-2N PF09263.10 ACT01504.1 - 0.17 12.3 0.0 0.24 11.8 0.0 1.2 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal HTH_11 PF08279.12 ACT01505.1 - 9e-10 38.4 0.0 1.7e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 HTH domain HTH_DeoR PF08220.12 ACT01505.1 - 5.4e-06 26.1 0.0 1.2e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain WYL PF13280.6 ACT01505.1 - 0.00086 19.4 0.0 0.0014 18.7 0.0 1.4 1 0 0 1 1 1 1 WYL domain Mga PF05043.13 ACT01505.1 - 0.013 16.0 0.1 0.031 14.9 0.1 1.6 1 0 0 1 1 1 0 Mga helix-turn-helix domain MarR_2 PF12802.7 ACT01505.1 - 0.15 12.0 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 MarR family YjcZ_2 PF09680.10 ACT01506.1 - 0.078 12.6 12.2 0.078 12.6 12.2 2.1 2 0 0 2 2 2 0 Family of unknown function TauE PF01925.19 ACT01507.1 - 0.00019 21.1 3.4 0.0029 17.3 0.2 2.0 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE DUF3796 PF12676.7 ACT01507.1 - 0.01 16.3 0.6 0.01 16.3 0.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3796) Tetraspanin PF00335.20 ACT01507.1 - 0.33 10.6 5.1 0.83 9.3 0.8 2.6 1 1 0 2 2 2 0 Tetraspanin family Orf78 PF06024.12 ACT01507.1 - 1.7 9.0 6.4 1.1 9.7 2.2 2.2 2 1 0 2 2 2 0 Orf78 (ac78) HTH_3 PF01381.22 ACT01508.1 - 4.3e-18 65.1 0.0 4.8e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 ACT01508.1 - 1.2e-10 41.3 0.3 1.3e-10 41.1 0.3 1.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ACT01508.1 - 1.1e-09 38.4 0.0 1.4e-09 38.2 0.0 1.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 ACT01508.1 - 2.9e-05 23.8 0.1 4.5e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 ACT01508.1 - 6.4e-05 23.3 0.0 8.8e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_11 PF08279.12 ACT01508.1 - 0.0016 18.3 0.0 0.0025 17.7 0.0 1.2 1 0 0 1 1 1 1 HTH domain Sigma70_r4 PF04545.16 ACT01508.1 - 0.014 14.9 0.2 0.048 13.2 0.1 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.6 ACT01508.1 - 0.014 15.2 0.0 0.09 12.6 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain YdaS_antitoxin PF15943.5 ACT01508.1 - 0.073 12.9 0.0 0.076 12.9 0.0 1.2 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT UIM PF02809.20 ACT01508.1 - 0.075 13.0 0.2 0.19 11.7 0.2 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif HTH_Crp_2 PF13545.6 ACT01508.1 - 0.13 12.2 0.0 0.29 11.1 0.0 1.6 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_28 PF13518.6 ACT01508.1 - 0.14 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain adh_short PF00106.25 ACT01509.1 - 5.5e-33 114.1 0.2 8.1e-28 97.2 0.4 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ACT01509.1 - 2.5e-23 82.9 0.3 2.5e-19 69.8 0.3 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT01509.1 - 4.3e-10 39.8 0.3 7.4e-10 39.0 0.3 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ACT01509.1 - 0.0017 18.3 0.1 0.0025 17.7 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ACT01509.1 - 0.06 12.8 0.1 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family FAD_binding_3 PF01494.19 ACT01509.1 - 0.087 12.1 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain GDP_Man_Dehyd PF16363.5 ACT01509.1 - 0.12 11.8 0.1 0.17 11.3 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Shikimate_DH PF01488.20 ACT01509.1 - 0.13 12.3 0.9 0.32 11.1 0.9 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TetR_N PF00440.23 ACT01510.1 - 1.6e-14 53.4 0.6 2.7e-14 52.7 0.6 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_29 PF17938.1 ACT01510.1 - 0.0022 18.1 0.0 0.057 13.5 0.0 2.2 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain His_Phos_1 PF00300.22 ACT01511.1 - 1.5e-25 90.0 0.0 2.4e-25 89.4 0.0 1.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) GP3_package PF16677.5 ACT01511.1 - 0.047 13.8 0.0 0.064 13.4 0.0 1.4 1 0 0 1 1 1 0 DNA-packaging protein gp3 DUF2007 PF09413.10 ACT01511.1 - 0.096 12.9 0.2 0.57 10.4 0.1 2.1 2 0 0 2 2 2 0 Putative prokaryotic signal transducing protein Aldo_ket_red PF00248.21 ACT01512.1 - 3.2e-60 203.8 0.0 1.4e-58 198.4 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Big_5 PF13205.6 ACT01513.1 - 1.1e-41 141.8 48.8 6.5e-07 30.0 0.1 9.1 7 2 2 9 9 9 8 Bacterial Ig-like domain CopC PF04234.12 ACT01513.1 - 4.3e-11 43.7 9.6 2.6 9.1 0.1 8.3 8 0 0 8 8 8 4 CopC domain SLH PF00395.20 ACT01513.1 - 4.3e-10 39.4 0.4 0.017 15.2 0.0 4.5 4 0 0 4 4 4 3 S-layer homology domain CE2_N PF17996.1 ACT01513.1 - 0.027 14.4 2.5 0.3 11.1 0.0 3.6 3 0 0 3 3 3 0 Carbohydrate esterase 2 N-terminal LysM PF01476.20 ACT01514.1 - 1.6e-20 72.9 3.5 1.2e-08 34.8 0.1 3.7 4 0 0 4 4 4 3 LysM domain Omega_Repress PF07764.11 ACT01514.1 - 0.11 13.1 0.8 0.28 11.8 0.1 2.1 2 1 0 2 2 2 0 Omega Transcriptional Repressor Amidase_3 PF01520.18 ACT01515.1 - 2e-45 155.1 0.0 3e-45 154.4 0.0 1.3 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase SH3_3 PF08239.11 ACT01515.1 - 3e-29 101.1 4.9 1.5e-14 53.9 0.2 3.0 3 0 0 3 3 3 2 Bacterial SH3 domain SH3_4 PF06347.13 ACT01515.1 - 5.6e-18 64.5 0.7 1.3e-08 34.5 0.0 2.5 2 0 0 2 2 2 2 Bacterial SH3 domain SH3_16 PF18348.1 ACT01515.1 - 4.8e-07 29.5 0.5 1.9e-05 24.3 0.2 2.5 2 0 0 2 2 2 1 Bacterial dipeptidyl-peptidase Sh3 domain HlyD_3 PF13437.6 ACT01515.1 - 0.0011 19.6 0.0 0.0054 17.4 0.0 2.0 2 0 0 2 2 2 1 HlyD family secretion protein GW PF13457.6 ACT01515.1 - 0.013 16.0 2.0 1 10.0 0.3 2.8 2 0 0 2 2 2 0 GW (Gly-Tryp) dipeptide domain SH3_2 PF07653.17 ACT01515.1 - 0.073 12.8 2.8 3.3 7.5 0.1 2.6 2 0 0 2 2 2 0 Variant SH3 domain Methyltransf_11 PF08241.12 ACT01516.1 - 5.2e-23 81.5 0.0 9.7e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT01516.1 - 6.3e-21 74.9 0.0 1.4e-20 73.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT01516.1 - 2.1e-17 63.3 0.0 2.9e-17 62.9 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ACT01516.1 - 5.5e-12 45.5 0.0 7e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ACT01516.1 - 2e-11 44.0 0.0 3.9e-11 43.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT01516.1 - 7.6e-10 39.4 0.0 3.4e-09 37.3 0.0 2.0 2 1 1 3 3 2 1 Methyltransferase domain TehB PF03848.14 ACT01516.1 - 3.8e-09 36.2 0.0 1.2e-08 34.7 0.0 1.7 2 0 0 2 2 2 1 Tellurite resistance protein TehB SAM_MT PF04445.13 ACT01516.1 - 0.00015 21.3 0.0 0.00024 20.6 0.0 1.3 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase MTS PF05175.14 ACT01516.1 - 0.00048 19.7 0.0 0.00074 19.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.20 ACT01516.1 - 0.0007 18.7 0.0 0.034 13.2 0.0 2.0 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase PCMT PF01135.19 ACT01516.1 - 0.00075 19.3 0.0 0.0085 15.9 0.0 2.0 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 ACT01516.1 - 0.0016 19.4 0.0 0.0029 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ACT01516.1 - 0.0022 17.6 0.0 0.0033 17.0 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 ACT01516.1 - 0.0022 17.9 0.0 0.0039 17.1 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase NodS PF05401.11 ACT01516.1 - 0.012 15.3 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) DUF938 PF06080.12 ACT01516.1 - 0.034 13.9 0.0 0.059 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) TPMT PF05724.11 ACT01516.1 - 0.048 13.3 0.0 0.11 12.2 0.0 1.6 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) CMAS PF02353.20 ACT01516.1 - 0.054 12.8 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 ACT01516.1 - 0.089 12.8 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain LSM PF01423.22 ACT01517.1 - 0.18 11.5 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 LSM domain GRP PF07172.11 ACT01517.1 - 0.89 10.3 15.4 1.4 9.7 15.4 1.3 1 0 0 1 1 1 0 Glycine rich protein family SM-ATX PF14438.6 ACT01518.1 - 0.008 16.3 0.1 0.077 13.2 0.0 2.2 2 0 0 2 2 2 1 Ataxin 2 SM domain LSM PF01423.22 ACT01518.1 - 0.014 15.1 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 LSM domain Tudor_2 PF18104.1 ACT01518.1 - 0.017 14.8 0.0 0.066 12.9 0.0 1.9 2 0 0 2 2 2 0 Jumonji domain-containing protein 2A Tudor domain LSM14 PF12701.7 ACT01518.1 - 0.024 14.7 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 Scd6-like Sm domain DUF4037 PF13228.6 ACT01519.1 - 7.8e-30 103.7 0.0 1.5e-29 102.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4037) Glyoxalase_2 PF12681.7 ACT01520.1 - 1.7e-16 60.2 0.0 2.1e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 ACT01520.1 - 4.7e-13 49.4 0.0 6.7e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ACT01520.1 - 1.2e-06 29.3 0.0 1.5e-06 28.9 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 ACT01520.1 - 0.0041 17.4 0.0 0.0093 16.2 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ABC_tran PF00005.27 ACT01523.1 - 2.3e-35 122.1 0.0 3e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01523.1 - 8.6e-12 45.5 0.0 1.8e-05 24.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT01523.1 - 2.6e-09 36.9 0.1 9.3e-08 31.8 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 ACT01523.1 - 3e-06 26.3 0.2 0.09 11.5 0.1 3.0 2 1 0 2 2 2 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 ACT01523.1 - 2.2e-05 24.9 0.0 4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT01523.1 - 0.00013 21.6 0.0 0.00026 20.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ACT01523.1 - 0.00064 20.0 0.1 0.0014 19.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT01523.1 - 0.0012 18.8 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 ACT01523.1 - 0.0014 18.8 0.0 0.0037 17.4 0.0 1.7 2 1 1 3 3 2 1 AAA domain AAA_13 PF13166.6 ACT01523.1 - 0.0016 17.2 0.0 0.016 13.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ACT01523.1 - 0.0018 18.0 0.1 0.0027 17.5 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ACT01523.1 - 0.0028 18.2 0.0 0.0043 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 ACT01523.1 - 0.0096 15.7 0.0 0.61 9.7 0.0 2.1 1 1 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 ACT01523.1 - 0.011 15.6 0.0 0.035 14.0 0.0 1.8 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea cobW PF02492.19 ACT01523.1 - 0.012 15.2 0.7 0.025 14.1 0.2 1.8 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 ACT01523.1 - 0.013 15.1 0.3 0.076 12.6 0.1 2.1 2 1 1 3 3 3 0 AAA domain AAA_27 PF13514.6 ACT01523.1 - 0.014 15.0 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ACT01523.1 - 0.016 15.8 0.0 0.028 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ACT01523.1 - 0.025 14.8 0.2 0.34 11.2 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.6 ACT01523.1 - 0.027 14.5 0.0 0.08 13.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ACT01523.1 - 0.031 13.4 0.0 0.065 12.4 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain T2SSE PF00437.20 ACT01523.1 - 0.041 12.9 0.0 0.067 12.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 ACT01523.1 - 0.044 13.7 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Rad17 PF03215.15 ACT01523.1 - 0.054 13.4 0.0 0.076 12.9 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain AAA PF00004.29 ACT01523.1 - 0.058 13.8 0.3 0.82 10.1 0.3 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 ACT01523.1 - 0.06 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase MMR_HSR1 PF01926.23 ACT01523.1 - 0.075 13.1 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase IstB_IS21 PF01695.17 ACT01523.1 - 0.085 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 ACT01523.1 - 0.089 13.0 0.1 0.42 10.8 0.0 2.1 3 0 0 3 3 3 0 AAA domain CobU PF02283.16 ACT01523.1 - 0.097 12.2 0.2 1.7 8.2 0.0 2.3 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase ATP_bind_1 PF03029.17 ACT01523.1 - 0.1 12.4 0.4 0.48 10.2 0.1 2.0 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 ACT01523.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ACT01523.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Pox_ATPase-GT PF10640.9 ACT01523.1 - 0.12 11.2 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase Septin PF00735.18 ACT01523.1 - 0.16 11.3 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Septin TK PF00265.18 ACT01523.1 - 0.19 11.6 0.1 3.2 7.6 0.0 2.1 2 0 0 2 2 2 0 Thymidine kinase RNA_helicase PF00910.22 ACT01523.1 - 0.22 11.9 0.2 2 8.8 0.1 2.5 3 1 1 4 4 2 0 RNA helicase SBP_bac_3 PF00497.20 ACT01524.1 - 5.4e-61 205.9 2.4 6.3e-61 205.7 2.4 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 ACT01524.1 - 4.8e-09 36.4 0.2 8.2e-08 32.4 0.2 2.3 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site OstA_2 PF13100.6 ACT01524.1 - 0.036 13.7 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 OstA-like protein LPAM_1 PF08139.12 ACT01524.1 - 2.5 8.7 6.1 5.6 7.7 6.1 1.6 1 1 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site BPD_transp_1 PF00528.22 ACT01525.1 - 8.6e-20 71.3 14.0 1.2e-19 70.8 14.0 1.2 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT01526.1 - 5.8e-19 68.5 12.8 5.8e-19 68.5 12.8 1.6 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component HATPase_c PF02518.26 ACT01527.1 - 8.3e-13 48.8 0.1 1.9e-12 47.7 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT01527.1 - 0.00023 21.0 0.0 0.00048 20.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT01527.1 - 0.00035 20.4 0.0 0.00077 19.3 0.0 1.5 1 0 0 1 1 1 1 GHKL domain DivIC PF04977.15 ACT01527.1 - 0.088 12.6 0.1 0.56 10.0 0.0 2.2 2 0 0 2 2 2 0 Septum formation initiator YcbB PF08664.10 ACT01528.1 - 3.4e-44 150.2 0.0 8.3e-44 148.9 0.0 1.6 2 0 0 2 2 2 1 YcbB domain Response_reg PF00072.24 ACT01528.1 - 8.7e-23 80.6 0.8 4.2e-22 78.4 0.2 2.0 2 0 0 2 2 2 1 Response regulator receiver domain PTE PF02126.18 ACT01528.1 - 0.033 13.6 0.1 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 Phosphotriesterase family RFC1 PF08519.12 ACT01528.1 - 0.057 13.6 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain EF-hand_6 PF13405.6 ACT01529.1 - 9.8e-05 22.0 0.3 0.47 10.5 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ACT01529.1 - 0.00071 18.9 0.2 0.48 10.1 0.0 2.6 2 0 0 2 2 2 2 EF hand Trypan_PARP PF05887.11 ACT01529.1 - 0.0024 17.9 6.1 0.0043 17.0 6.1 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) N_formyltrans_C PF18216.1 ACT01529.1 - 0.14 11.8 0.0 5.9 6.7 0.0 2.4 2 0 0 2 2 2 0 N-formyltransferase dimerization C-terminal domain EF-hand_8 PF13833.6 ACT01529.1 - 0.14 12.0 0.1 14 5.6 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair BPD_transp_1 PF00528.22 ACT01530.1 - 8e-17 61.6 13.6 8e-17 61.6 13.6 2.2 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Baculo_11_kDa PF06143.11 ACT01530.1 - 0.31 10.6 0.1 0.31 10.6 0.1 2.1 3 0 0 3 3 3 0 Baculovirus 11 kDa family BPD_transp_1 PF00528.22 ACT01531.1 - 1.6e-12 47.5 26.7 1.6e-12 47.5 26.7 2.2 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component UbiA PF01040.18 ACT01533.1 - 0.026 13.8 0.7 0.03 13.6 0.7 1.0 1 0 0 1 1 1 0 UbiA prenyltransferase family DUF2633 PF11119.8 ACT01533.1 - 0.5 10.3 2.6 0.71 9.8 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2633) DUF1514 PF07438.11 ACT01533.1 - 6.4 6.7 11.1 0.42 10.5 2.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1514) AAA_16 PF13191.6 ACT01534.1 - 4.7e-15 56.4 0.0 5.9e-08 33.3 0.0 2.4 2 1 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 ACT01534.1 - 8e-12 45.3 0.0 0.00011 22.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ACT01534.1 - 2.3e-10 40.9 0.0 4.9e-05 23.6 0.0 2.7 2 1 0 2 2 2 2 AAA domain NTPase_1 PF03266.15 ACT01534.1 - 3e-10 40.3 0.0 0.00046 20.1 0.0 2.3 2 0 0 2 2 2 2 NTPase ABC_tran PF00005.27 ACT01534.1 - 9.1e-10 39.2 0.2 0.00099 19.6 0.0 2.8 2 2 0 2 2 2 2 ABC transporter AAA_18 PF13238.6 ACT01534.1 - 3.4e-09 37.3 0.2 0.0046 17.5 0.0 3.0 3 1 0 3 3 2 2 AAA domain ATPase_2 PF01637.18 ACT01534.1 - 6.1e-09 36.1 0.0 0.0002 21.3 0.0 2.6 2 1 0 2 2 2 2 ATPase domain predominantly from Archaea NACHT PF05729.12 ACT01534.1 - 1e-08 35.3 0.0 0.00042 20.3 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_5 PF07728.14 ACT01534.1 - 1.5e-08 34.7 0.0 0.0013 18.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 ACT01534.1 - 6.4e-08 32.7 0.0 0.011 15.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase RNA_helicase PF00910.22 ACT01534.1 - 9.7e-08 32.4 0.0 0.02 15.2 0.0 2.8 2 1 0 2 2 2 2 RNA helicase CbiA PF01656.23 ACT01534.1 - 2.9e-07 30.6 0.0 0.0022 18.1 0.0 2.4 2 0 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 ACT01534.1 - 6.1e-07 29.9 0.3 0.0021 18.5 0.0 2.7 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 ACT01534.1 - 6.3e-07 28.7 0.0 0.0067 15.4 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 ACT01534.1 - 6.7e-07 29.0 0.1 0.0089 15.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_28 PF13521.6 ACT01534.1 - 7.4e-07 29.5 0.1 0.063 13.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.6 ACT01534.1 - 1.2e-06 28.8 1.1 0.072 13.3 0.0 2.9 2 1 0 3 3 3 2 AAA domain SRP54 PF00448.22 ACT01534.1 - 1.2e-06 28.3 0.0 0.0066 16.1 0.0 2.4 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_14 PF13173.6 ACT01534.1 - 1.5e-06 28.3 0.0 0.0031 17.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain Ploopntkinase3 PF18751.1 ACT01534.1 - 2.3e-06 27.7 0.0 0.0073 16.2 0.0 2.5 2 0 0 2 2 2 2 P-loop Nucleotide Kinase3 Rad17 PF03215.15 ACT01534.1 - 3.6e-06 27.0 0.0 0.0066 16.4 0.0 2.3 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_7 PF12775.7 ACT01534.1 - 4.1e-06 26.4 0.0 0.013 15.0 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region TsaE PF02367.17 ACT01534.1 - 1.1e-05 25.4 0.1 0.24 11.4 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 ACT01534.1 - 1.3e-05 24.6 0.2 0.08 12.2 0.0 2.6 3 0 0 3 3 2 2 Zeta toxin ATP_bind_1 PF03029.17 ACT01534.1 - 1.3e-05 25.1 0.1 0.19 11.5 0.0 2.6 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 ACT01534.1 - 1.4e-05 25.2 0.1 0.084 13.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase KTI12 PF08433.10 ACT01534.1 - 1.5e-05 24.6 0.1 0.042 13.3 0.0 2.4 2 0 0 2 2 2 2 Chromatin associated protein KTI12 KAP_NTPase PF07693.14 ACT01534.1 - 1.5e-05 24.4 0.0 0.12 11.6 0.0 2.2 1 1 1 2 2 2 2 KAP family P-loop domain DUF815 PF05673.13 ACT01534.1 - 1.8e-05 24.0 0.0 0.034 13.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_19 PF13245.6 ACT01534.1 - 2.8e-05 24.5 0.1 0.26 11.6 0.0 2.9 3 0 0 3 3 2 2 AAA domain Viral_helicase1 PF01443.18 ACT01534.1 - 3.1e-05 23.8 0.1 0.028 14.2 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase PIF1 PF05970.14 ACT01534.1 - 3.2e-05 23.3 0.0 0.064 12.4 0.0 2.2 2 0 0 2 2 2 2 PIF1-like helicase cobW PF02492.19 ACT01534.1 - 3.4e-05 23.5 0.2 0.088 12.4 0.0 2.9 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 ACT01534.1 - 3.9e-05 23.5 0.4 0.23 11.2 0.1 2.5 2 2 0 2 2 2 2 AAA domain DAP3 PF10236.9 ACT01534.1 - 5.9e-05 22.4 0.0 0.009 15.2 0.0 2.3 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 VirE PF05272.11 ACT01534.1 - 7.6e-05 22.5 0.0 0.41 10.3 0.0 2.6 3 0 0 3 3 2 2 Virulence-associated protein E NB-ARC PF00931.22 ACT01534.1 - 8.9e-05 21.8 0.0 0.14 11.4 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain MobB PF03205.14 ACT01534.1 - 9.1e-05 22.4 0.0 0.34 10.8 0.0 2.4 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_PrkA PF08298.11 ACT01534.1 - 0.00011 21.2 0.0 0.003 16.5 0.0 2.2 2 0 0 2 2 2 1 PrkA AAA domain Thymidylate_kin PF02223.17 ACT01534.1 - 0.00013 21.7 0.2 0.27 10.9 0.0 3.0 3 0 0 3 3 3 1 Thymidylate kinase CLP1_P PF16575.5 ACT01534.1 - 0.00026 20.9 0.0 0.53 10.1 0.0 3.3 3 0 0 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop APS_kinase PF01583.20 ACT01534.1 - 0.00033 20.6 0.0 0.49 10.3 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase IstB_IS21 PF01695.17 ACT01534.1 - 0.00039 20.2 0.7 0.89 9.3 0.0 3.1 4 0 0 4 4 2 1 IstB-like ATP binding protein DUF2075 PF09848.9 ACT01534.1 - 0.00047 19.5 0.0 0.054 12.7 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ParA PF10609.9 ACT01534.1 - 0.00072 19.1 0.0 0.3 10.5 0.0 2.6 3 0 0 3 3 2 1 NUBPL iron-transfer P-loop NTPase AAA_17 PF13207.6 ACT01534.1 - 0.00077 19.9 0.7 0.37 11.2 0.1 2.7 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 ACT01534.1 - 0.00079 19.3 0.1 0.36 10.6 0.0 2.5 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 ACT01534.1 - 0.00081 19.0 0.0 1 8.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.9 ACT01534.1 - 0.00085 18.3 0.0 0.56 9.0 0.0 2.3 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain Fe-ADH PF00465.19 ACT01534.1 - 0.00087 18.2 0.0 0.11 11.3 0.0 2.7 3 0 0 3 3 3 1 Iron-containing alcohol dehydrogenase Cytidylate_kin PF02224.18 ACT01534.1 - 0.0011 18.7 0.7 0.29 10.9 0.0 2.7 2 1 0 2 2 2 1 Cytidylate kinase Fer4_NifH PF00142.18 ACT01534.1 - 0.0013 18.2 0.0 0.12 11.8 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family PTS_IIB PF02302.17 ACT01534.1 - 0.0013 19.3 0.0 0.093 13.4 0.0 2.5 2 0 0 2 2 2 1 PTS system, Lactose/Cellobiose specific IIB subunit Sigma54_activat PF00158.26 ACT01534.1 - 0.0026 17.5 0.0 3.5 7.3 0.0 3.0 2 1 0 3 3 3 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 ACT01534.1 - 0.0029 17.0 0.1 2.1 7.7 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI FtsK_SpoIIIE PF01580.18 ACT01534.1 - 0.0047 16.3 0.0 0.53 9.6 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family Helicase_RecD PF05127.14 ACT01534.1 - 0.0054 16.6 0.0 2.4 8.0 0.0 2.8 3 0 0 3 3 2 0 Helicase AAA_3 PF07726.11 ACT01534.1 - 0.0057 16.5 0.0 1.2 9.0 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 ACT01534.1 - 0.0058 15.7 0.1 3.1 6.8 0.0 2.5 3 0 0 3 3 2 0 Type II/IV secretion system protein Guanylate_kin PF00625.21 ACT01534.1 - 0.011 15.5 0.0 0.27 10.9 0.0 2.4 2 0 0 2 2 2 0 Guanylate kinase dNK PF01712.19 ACT01534.1 - 0.012 15.5 0.3 2.3 8.0 0.0 3.0 3 0 0 3 3 3 0 Deoxynucleoside kinase DUF853 PF05872.12 ACT01534.1 - 0.016 13.9 0.0 3.5 6.1 0.0 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) PduV-EutP PF10662.9 ACT01534.1 - 0.03 14.1 0.0 11 5.8 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP-synt_D PF01813.17 ACT01534.1 - 0.034 14.0 2.8 2.6 7.8 0.4 2.3 2 0 0 2 2 2 0 ATP synthase subunit D 6PF2K PF01591.18 ACT01534.1 - 0.039 13.2 0.0 2 7.7 0.0 2.5 2 0 0 2 2 2 0 6-phosphofructo-2-kinase AAA_32 PF13654.6 ACT01534.1 - 0.041 12.7 1.3 3 6.5 0.1 3.2 3 1 0 3 3 3 0 AAA domain Adeno_IVa2 PF02456.15 ACT01534.1 - 0.05 12.4 0.0 1.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein Roc PF08477.13 ACT01534.1 - 0.057 13.6 0.4 11 6.3 0.0 2.6 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ACT01534.1 - 0.095 12.2 0.0 3.7 7.0 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family G-alpha PF00503.20 ACT01534.1 - 0.1 11.8 0.2 3.4 6.7 0.0 2.5 3 0 0 3 3 3 0 G-protein alpha subunit SKI PF01202.22 ACT01534.1 - 0.1 12.7 0.2 15 5.7 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase MCM PF00493.23 ACT01534.1 - 0.11 11.5 0.1 3.4 6.7 0.0 2.8 3 0 0 3 3 3 0 MCM P-loop domain Torsin PF06309.11 ACT01534.1 - 0.12 12.5 0.0 5.8 7.0 0.0 2.6 2 0 0 2 2 2 0 Torsin PRK PF00485.18 ACT01534.1 - 0.14 11.9 0.1 9 6.0 0.0 2.9 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.17 ACT01534.1 - 0.14 12.2 2.6 5.8 6.9 0.0 3.4 4 0 0 4 4 4 0 Helicase HerA, central domain FeoB_N PF02421.18 ACT01534.1 - 0.16 11.5 0.0 6.8 6.2 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_23 PF13476.6 ACT01534.1 - 0.16 12.4 1.7 27 5.2 0.0 2.9 4 0 0 4 4 2 0 AAA domain YPEB PF14620.6 ACT01535.1 - 9.5e-05 21.9 2.5 0.00092 18.7 0.0 2.5 2 1 0 2 2 2 1 YpeB sporulation Asparaginase PF00710.20 ACT01535.1 - 0.11 12.0 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 Asparaginase, N-terminal DUF5336 PF17270.2 ACT01536.1 - 0.093 12.4 0.1 0.1 12.3 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5336) MarR_2 PF12802.7 ACT01537.1 - 1.3e-14 53.8 0.0 1.8e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT01537.1 - 5.1e-07 30.1 0.0 8.1e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.22 ACT01537.1 - 0.00015 21.6 0.0 0.0003 20.6 0.0 1.6 1 0 0 1 1 1 1 MarR family ITAM_Cys-rich PF10538.9 ACT01537.1 - 0.042 13.6 0.2 0.086 12.6 0.2 1.6 1 0 0 1 1 1 0 Immunoreceptor tyrosine-based activation motif ABC_tran PF00005.27 ACT01538.1 - 3.5e-48 163.6 5.3 1.9e-23 83.5 0.1 3.3 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 ACT01538.1 - 4.1e-16 59.7 15.8 5.9e-05 23.0 0.6 5.2 4 1 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT01538.1 - 1e-12 48.0 5.9 0.00096 18.6 0.0 4.5 4 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain ABC_tran_Xtn PF12848.7 ACT01538.1 - 7.5e-12 45.1 21.2 1.9e-10 40.6 15.8 3.1 2 1 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 ACT01538.1 - 5.6e-06 26.8 1.3 0.092 13.1 0.1 3.2 3 0 0 3 3 3 2 AAA ATPase domain NB-ARC PF00931.22 ACT01538.1 - 7.6e-06 25.3 0.5 0.066 12.4 0.0 3.1 3 0 0 3 3 3 2 NB-ARC domain MMR_HSR1 PF01926.23 ACT01538.1 - 2.2e-05 24.5 0.0 0.27 11.3 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.6 ACT01538.1 - 2.2e-05 24.7 0.1 0.11 12.6 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 ACT01538.1 - 2.6e-05 24.5 4.7 0.00097 19.4 0.1 2.9 3 1 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 ACT01538.1 - 2.7e-05 24.2 1.2 0.29 11.0 0.1 3.0 2 1 0 2 2 2 2 RsgA GTPase AAA PF00004.29 ACT01538.1 - 5.8e-05 23.5 0.3 0.11 12.9 0.0 2.9 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ACT01538.1 - 8.7e-05 22.6 0.2 0.3 11.1 0.0 3.6 4 0 0 4 4 2 1 AAA domain AAA_29 PF13555.6 ACT01538.1 - 0.00026 20.6 0.4 0.35 10.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain PduV-EutP PF10662.9 ACT01538.1 - 0.00038 20.2 0.8 0.15 11.8 0.1 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.17 ACT01538.1 - 0.00044 20.0 2.5 0.67 9.7 0.0 4.5 4 1 1 5 5 5 1 IstB-like ATP binding protein AAA_24 PF13479.6 ACT01538.1 - 0.00044 20.0 0.6 0.32 10.7 0.1 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ACT01538.1 - 0.001 19.6 3.7 0.67 10.5 0.1 3.2 2 2 0 2 2 2 2 AAA domain Rad17 PF03215.15 ACT01538.1 - 0.0014 18.6 0.7 0.0074 16.2 0.0 2.4 3 0 0 3 3 2 1 Rad17 P-loop domain cobW PF02492.19 ACT01538.1 - 0.0021 17.7 0.9 0.91 9.1 0.0 3.1 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 ACT01538.1 - 0.0022 18.4 0.2 2.1 8.8 0.0 3.3 4 0 0 4 4 2 1 RNA helicase Zeta_toxin PF06414.12 ACT01538.1 - 0.0025 17.1 0.0 0.35 10.1 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin TsaE PF02367.17 ACT01538.1 - 0.0026 17.8 0.8 1.4 8.9 0.0 2.8 2 1 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 ACT01538.1 - 0.0038 17.4 2.5 0.31 11.3 0.0 3.1 3 1 1 4 4 2 1 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.25 ACT01538.1 - 0.0038 16.9 0.2 0.044 13.4 0.0 2.3 3 0 0 3 3 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_7 PF12775.7 ACT01538.1 - 0.0039 16.7 0.2 0.39 10.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_28 PF13521.6 ACT01538.1 - 0.0047 17.2 2.3 0.29 11.4 0.0 3.2 3 0 0 3 3 2 1 AAA domain SRP54 PF00448.22 ACT01538.1 - 0.0099 15.5 0.7 1.9 8.1 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain NACHT PF05729.12 ACT01538.1 - 0.01 15.8 2.4 1.5 8.7 0.6 2.8 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.23 ACT01538.1 - 0.01 15.9 3.3 4.9 7.2 0.1 3.5 3 1 0 3 3 3 0 Dynamin family Arf PF00025.21 ACT01538.1 - 0.011 15.2 0.2 2.5 7.5 0.0 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family NTPase_1 PF03266.15 ACT01538.1 - 0.018 14.9 2.6 10 6.0 0.0 3.5 3 0 0 3 3 3 0 NTPase AAA_25 PF13481.6 ACT01538.1 - 0.018 14.6 0.2 0.94 9.0 0.0 2.8 2 1 0 2 2 2 0 AAA domain Septin PF00735.18 ACT01538.1 - 0.021 14.1 0.1 7.2 5.8 0.0 2.6 2 0 0 2 2 2 0 Septin Viral_helicase1 PF01443.18 ACT01538.1 - 0.025 14.3 0.0 0.75 9.5 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 ACT01538.1 - 0.026 13.9 0.0 8.3 5.7 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 ACT01538.1 - 0.031 14.2 1.0 1.5 8.6 0.0 3.1 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea MobB PF03205.14 ACT01538.1 - 0.037 13.9 2.8 6.7 6.6 0.0 3.0 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.6 ACT01538.1 - 0.048 14.2 28.2 5 7.6 6.6 4.0 2 2 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ACT01538.1 - 0.052 13.5 0.9 3.6 7.6 0.4 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 ACT01538.1 - 0.074 13.4 1.0 0.59 10.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ACT01538.1 - 0.082 12.6 13.8 1.1 8.9 0.0 4.0 2 1 1 5 5 4 0 AAA ATPase domain RuvB_N PF05496.12 ACT01538.1 - 0.082 12.7 0.3 26 4.5 0.0 3.2 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain DUF4350 PF14258.6 ACT01538.1 - 0.17 12.4 0.1 12 6.4 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) AAA_13 PF13166.6 ACT01538.1 - 0.19 10.3 9.7 0.75 8.4 0.2 3.6 3 1 0 4 4 4 0 AAA domain MeaB PF03308.16 ACT01538.1 - 0.22 10.5 5.9 1.6 7.7 0.1 2.9 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 ACT01538.1 - 0.25 10.9 1.6 11 5.5 0.0 2.9 3 0 0 3 3 3 0 Ferrous iron transport protein B Thymidylate_kin PF02223.17 ACT01538.1 - 0.39 10.4 6.6 0.75 9.4 0.0 3.5 3 0 0 3 3 3 0 Thymidylate kinase SRPRB PF09439.10 ACT01538.1 - 1 8.8 4.3 3.4 7.1 0.0 3.0 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Pox_F15 PF04596.12 ACT01540.1 - 0.043 13.6 0.8 0.052 13.3 0.8 1.1 1 0 0 1 1 1 0 Poxvirus protein F15 Beta-lactamase PF00144.24 ACT01541.1 - 7e-52 176.7 0.0 1e-51 176.2 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF5412 PF17428.2 ACT01542.1 - 1.5e-13 50.6 0.7 2.1e-13 50.2 0.7 1.3 1 1 0 1 1 1 1 Family of unknown function (DUF5412) DUF5071 PF16804.5 ACT01543.1 - 4e-38 130.3 0.8 4.5e-38 130.1 0.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5071) Pox_T4_N PF04491.12 ACT01543.1 - 0.14 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Poxvirus T4 protein, N terminus Methyltransf_25 PF13649.6 ACT01544.1 - 2.1e-11 44.4 0.0 4.2e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT01544.1 - 3.7e-07 30.7 0.0 6.5e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT01544.1 - 1.5e-06 28.9 0.0 2.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT01544.1 - 1.6e-05 24.8 0.0 6.7e-05 22.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ACT01544.1 - 0.017 14.5 0.0 0.079 12.3 0.0 1.9 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ACT01544.1 - 0.031 14.1 0.0 0.062 13.1 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain DUF3081 PF11280.8 ACT01544.1 - 0.076 12.9 0.3 0.18 11.6 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3081) MFS_1 PF07690.16 ACT01545.1 - 6.2e-58 196.4 47.1 1.4e-39 136.1 14.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01545.1 - 1.3e-12 47.3 34.1 8.5e-12 44.7 12.0 2.1 1 1 0 2 2 2 2 Sugar (and other) transporter MFS_3 PF05977.13 ACT01545.1 - 5e-06 25.2 10.2 5e-06 25.2 10.2 1.9 1 1 1 2 2 2 2 Transmembrane secretion effector MFS_1_like PF12832.7 ACT01545.1 - 1.5e-05 24.0 12.0 1.5e-05 24.0 12.0 2.3 1 1 1 2 2 2 1 MFS_1 like family BT1 PF03092.16 ACT01545.1 - 0.00047 18.5 6.7 0.035 12.3 1.6 2.5 2 0 0 2 2 2 2 BT1 family LacY_symp PF01306.19 ACT01545.1 - 0.036 12.8 37.6 0.015 14.1 12.3 2.8 2 1 0 2 2 2 0 LacY proton/sugar symporter OATP PF03137.20 ACT01545.1 - 1.9 6.7 17.2 0.31 9.3 4.0 2.9 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family LysR_substrate PF03466.20 ACT01546.1 - 3.2e-40 137.7 0.2 6e-40 136.8 0.2 1.4 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01546.1 - 6.7e-19 67.6 0.8 6.7e-19 67.6 0.8 2.5 3 0 0 3 3 3 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR_2 PF12802.7 ACT01546.1 - 0.00014 21.7 0.9 0.0013 18.5 0.3 2.6 2 1 0 2 2 2 1 MarR family HTH_28 PF13518.6 ACT01546.1 - 0.00082 19.5 0.0 0.0023 18.0 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_30 PF13556.6 ACT01546.1 - 0.0056 16.4 0.2 0.011 15.5 0.2 1.4 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain MarR PF01047.22 ACT01546.1 - 0.022 14.7 0.3 0.082 12.8 0.1 2.1 2 0 0 2 2 2 0 MarR family HTH_23 PF13384.6 ACT01546.1 - 0.034 14.0 0.1 0.16 11.8 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain PBP_like PF12727.7 ACT01546.1 - 0.066 12.3 0.0 0.31 10.1 0.0 2.1 1 1 0 1 1 1 0 PBP superfamily domain RWP-RK PF02042.15 ACT01546.1 - 0.16 12.0 0.0 8.8 6.4 0.0 2.5 2 0 0 2 2 2 0 RWP-RK domain HTH_20 PF12840.7 ACT01546.1 - 0.26 11.4 3.3 2.7 8.1 0.3 3.1 3 1 0 3 3 3 0 Helix-turn-helix domain Peripla_BP_3 PF13377.6 ACT01547.1 - 6e-34 117.8 0.0 9.4e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT01547.1 - 1.8e-22 80.1 0.0 2.3e-22 79.7 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT01547.1 - 5e-17 61.4 0.0 9.9e-17 60.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACT01547.1 - 2.5e-14 53.5 0.0 3.5e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_3 PF01381.22 ACT01547.1 - 3.7e-05 23.7 0.1 7.7e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix MarR_2 PF12802.7 ACT01547.1 - 0.00022 21.1 0.0 0.00085 19.2 0.0 2.0 2 0 0 2 2 2 1 MarR family HTH_IclR PF09339.10 ACT01547.1 - 0.00023 20.9 0.0 0.00093 18.9 0.0 2.0 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_38 PF13936.6 ACT01547.1 - 0.00031 20.4 0.4 0.00068 19.4 0.4 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 ACT01547.1 - 0.00073 19.3 0.4 0.0021 17.8 0.2 1.9 1 1 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 ACT01547.1 - 0.0019 17.6 0.1 0.0037 16.7 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_31 PF13560.6 ACT01547.1 - 0.0028 18.0 0.0 0.006 16.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain TetR_N PF00440.23 ACT01547.1 - 0.0028 17.4 0.3 0.013 15.2 0.0 2.3 3 0 0 3 3 2 1 Bacterial regulatory proteins, tetR family MarR PF01047.22 ACT01547.1 - 0.0035 17.2 0.1 0.0087 16.0 0.1 1.7 1 0 0 1 1 1 1 MarR family Sigma70_r4 PF04545.16 ACT01547.1 - 0.0049 16.3 1.0 0.0074 15.8 0.1 1.8 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_24 PF13412.6 ACT01547.1 - 0.0076 15.8 0.1 0.016 14.7 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_36 PF13730.6 ACT01547.1 - 0.017 15.1 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_7 PF02796.15 ACT01547.1 - 0.024 14.7 0.1 0.049 13.7 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_28 PF13518.6 ACT01547.1 - 0.04 14.0 0.2 0.2 11.8 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain DUF5615 PF18480.1 ACT01547.1 - 0.056 13.2 0.3 0.37 10.6 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5615) HTH_19 PF12844.7 ACT01547.1 - 0.056 13.5 0.0 0.095 12.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.6 ACT01547.1 - 0.059 13.4 0.0 0.17 12.0 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn helix Sigma54_DBD PF04552.13 ACT01547.1 - 0.06 13.1 0.0 0.31 10.7 0.0 2.0 2 0 0 2 2 2 0 Sigma-54, DNA binding domain MerR PF00376.23 ACT01547.1 - 0.088 12.6 0.3 0.19 11.5 0.3 1.6 1 0 0 1 1 1 0 MerR family regulatory protein HTH_Crp_2 PF13545.6 ACT01547.1 - 0.093 12.7 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain CENP-B_N PF04218.13 ACT01547.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_AsnC-type PF13404.6 ACT01547.1 - 0.12 12.2 0.0 0.41 10.5 0.0 1.9 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_17 PF12728.7 ACT01547.1 - 0.13 12.5 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_6 PF01418.17 ACT01547.1 - 0.15 12.1 0.0 0.4 10.7 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family HTH_5 PF01022.20 ACT01547.1 - 0.68 9.8 0.0 0.68 9.8 0.0 2.5 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family BPD_transp_1 PF00528.22 ACT01548.1 - 6.6e-10 39.0 16.9 6.6e-10 39.0 16.9 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 ACT01549.1 - 1.5e-32 112.9 0.0 3.3e-32 111.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter TOBE_2 PF08402.10 ACT01549.1 - 2.6e-09 37.1 0.0 6.3e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 TOBE domain AAA_21 PF13304.6 ACT01549.1 - 4.1e-09 36.7 1.0 1.3e-05 25.2 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 ACT01549.1 - 0.00013 22.0 0.0 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 ACT01549.1 - 0.00036 21.0 0.1 0.0034 17.8 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ACT01549.1 - 0.00037 20.8 1.0 0.0044 17.3 1.0 2.1 1 1 0 1 1 1 1 AAA domain TOBE PF03459.17 ACT01549.1 - 0.00079 19.7 0.0 0.0057 16.9 0.0 2.3 2 0 0 2 2 2 1 TOBE domain RsgA_GTPase PF03193.16 ACT01549.1 - 0.0009 19.2 0.5 0.0018 18.2 0.1 1.6 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 ACT01549.1 - 0.0016 17.9 0.4 0.053 13.0 0.4 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACT01549.1 - 0.0018 18.7 0.2 0.0038 17.6 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 ACT01549.1 - 0.0075 15.9 0.4 0.29 10.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain TOBE_3 PF12857.7 ACT01549.1 - 0.0095 15.8 0.0 0.068 13.1 0.0 2.3 2 0 0 2 2 2 1 TOBE-like domain SbcCD_C PF13558.6 ACT01549.1 - 0.033 14.4 0.5 0.41 10.9 0.5 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit CysA_C_terminal PF17850.1 ACT01549.1 - 0.054 14.1 0.2 0.23 12.1 0.0 2.2 2 1 0 2 2 1 0 CysA C-terminal regulatory domain AAA_33 PF13671.6 ACT01549.1 - 0.067 13.3 0.1 0.25 11.5 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ACT01549.1 - 0.11 13.0 0.4 0.3 11.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ACT01549.1 - 0.12 12.4 0.1 0.5 10.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) OB_MalK PF17912.1 ACT01549.1 - 0.14 13.0 0.1 0.92 10.4 0.0 2.5 2 1 0 2 2 1 0 MalK OB fold domain AAA_30 PF13604.6 ACT01549.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ACT01549.1 - 0.15 12.6 0.0 0.58 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ACT01549.1 - 0.17 11.6 0.6 1.4 8.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ACT01549.1 - 0.17 11.6 0.2 0.36 10.6 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SBP_bac_8 PF13416.6 ACT01550.1 - 4.5e-29 102.2 2.8 7.7e-29 101.4 2.8 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT01550.1 - 3.2e-20 73.3 6.6 4.7e-20 72.8 6.6 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT01550.1 - 5.9e-15 55.3 0.3 1.1e-14 54.5 0.3 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT01550.1 - 1.2e-12 48.1 0.0 1.7e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT01551.1 - 6.5e-10 39.0 17.3 6.5e-10 39.0 17.3 2.6 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component DUF2070 PF09843.9 ACT01551.1 - 3.1 6.0 19.7 0.047 12.0 12.7 1.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) PHP PF02811.19 ACT01553.1 - 5.5e-08 33.3 0.0 5.5e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 PHP domain GDPD PF03009.17 ACT01554.1 - 2.3e-21 76.7 0.0 7.5e-20 71.7 0.0 2.0 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ACT01554.1 - 3e-07 30.7 0.1 8.3e-07 29.3 0.1 1.8 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF2181 PF10223.9 ACT01554.1 - 0.11 11.9 0.1 1.5 8.3 0.1 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2181) TPP_enzyme_N PF02776.18 ACT01555.1 - 1.6e-53 180.9 0.0 6.5e-53 178.9 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 ACT01555.1 - 4.8e-51 172.6 0.1 3.8e-49 166.4 0.0 2.6 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ACT01555.1 - 6.9e-47 158.6 0.0 1.3e-46 157.8 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 ACT01555.1 - 0.0097 15.7 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg XFP_N PF09364.10 ACT01555.1 - 0.13 11.0 0.0 0.23 10.2 0.0 1.3 1 0 0 1 1 1 0 XFP N-terminal domain ALS_ss_C PF10369.9 ACT01556.1 - 1e-26 92.9 0.5 4.1e-26 91.0 0.1 1.9 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT_5 PF13710.6 ACT01556.1 - 9.9e-18 63.8 0.0 1.8e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 ACT domain ACT PF01842.25 ACT01556.1 - 3e-13 49.3 0.1 6.4e-13 48.2 0.0 1.6 2 0 0 2 2 2 1 ACT domain DAHP_snth_FXD PF18152.1 ACT01556.1 - 0.0067 16.2 0.4 1 9.2 0.1 2.4 2 0 0 2 2 2 2 DAHP synthase ferredoxin-like domain ACT_4 PF13291.6 ACT01556.1 - 0.011 16.4 0.1 0.032 14.8 0.1 1.8 1 1 0 1 1 1 0 ACT domain GerA PF03323.13 ACT01559.1 - 2.6e-191 636.1 4.7 3e-191 635.9 4.7 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein PgaD PF13994.6 ACT01559.1 - 0.8 9.8 5.4 0.65 10.0 0.3 2.8 3 0 0 3 3 3 0 PgaD-like protein Spore_GerAC PF05504.11 ACT01560.1 - 3.3e-36 125.0 0.2 4.9e-36 124.4 0.2 1.3 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal DMT_YdcZ PF04657.13 ACT01561.1 - 0.011 16.0 1.3 0.012 15.9 1.3 1.1 1 0 0 1 1 1 0 Putative inner membrane exporter, YdcZ UbiA PF01040.18 ACT01561.1 - 0.041 13.2 1.3 0.044 13.1 1.3 1.0 1 0 0 1 1 1 0 UbiA prenyltransferase family DUF2721 PF11026.8 ACT01561.1 - 0.15 11.9 1.6 0.17 11.8 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Spore_permease PF03845.13 ACT01562.1 - 2.2e-49 168.0 30.7 2.7e-49 167.7 30.7 1.1 1 0 0 1 1 1 1 Spore germination protein SLAC1 PF03595.17 ACT01563.1 - 2e-54 185.0 39.9 2.5e-54 184.7 39.9 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Glycophorin_A PF01102.18 ACT01563.1 - 9 6.6 6.2 13 6.0 0.5 2.4 2 0 0 2 2 2 0 Glycophorin A Trp_oprn_chp PF09534.10 ACT01563.1 - 9.8 5.9 7.1 0.88 9.3 1.9 1.8 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) AA_permease PF00324.21 ACT01564.1 - 6.8e-138 460.2 42.8 7.7e-138 460.1 42.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ACT01564.1 - 3.4e-45 154.7 47.7 4e-45 154.4 47.7 1.1 1 0 0 1 1 1 1 Amino acid permease DUF11 PF01345.18 ACT01565.1 - 1.2e-19 70.4 4.4 1.7e-08 34.6 0.0 4.4 4 0 0 4 4 4 3 Domain of unknown function DUF11 CARDB PF07705.11 ACT01565.1 - 0.0035 17.6 2.8 30 4.9 0.1 4.8 4 1 0 4 4 4 2 CARDB TRAP_beta PF05753.14 ACT01565.1 - 0.25 10.7 2.2 5.6 6.3 0.0 2.8 3 0 0 3 3 3 0 Translocon-associated protein beta (TRAPB) DUF11 PF01345.18 ACT01566.1 - 6.5e-160 520.0 245.9 2.4e-13 50.2 6.8 17.2 17 1 1 18 18 18 15 Domain of unknown function DUF11 bMG10 PF17973.1 ACT01566.1 - 1.1e-21 77.4 42.8 0.028 14.6 0.1 15.3 14 1 2 16 16 16 8 Bacterial Alpha-2-macroglobulin MG10 domain Collagen_bind PF05737.12 ACT01566.1 - 1.5e-12 47.9 11.6 4.9 7.3 0.0 11.4 12 1 0 12 12 12 4 Collagen binding domain DUF4139 PF13598.6 ACT01566.1 - 0.0003 20.6 33.7 0.92 9.2 0.1 10.1 9 1 0 9 9 9 2 Domain of unknown function (DUF4139) NPCBM_assoc PF10633.9 ACT01566.1 - 0.0014 18.8 111.1 0.34 11.2 0.8 21.8 18 6 1 19 19 19 6 NPCBM-associated, NEW3 domain of alpha-galactosidase CARDB PF07705.11 ACT01566.1 - 0.0029 17.8 151.8 0.095 13.0 0.3 19.1 15 7 2 17 17 17 9 CARDB TRAP_beta PF05753.14 ACT01566.1 - 0.02 14.3 61.1 0.58 9.5 0.2 11.8 13 1 0 13 13 13 0 Translocon-associated protein beta (TRAPB) GramPos_pilinBB PF16569.5 ACT01566.1 - 0.65 10.8 18.6 9.4 7.1 0.0 8.2 7 1 0 8 8 8 0 Gram-positive pilin backbone subunit 2, Cna-B-like domain Chitin_bind_4 PF00379.23 ACT01566.1 - 1.2 9.7 5.8 7.8 7.1 0.0 4.6 5 0 0 5 5 5 0 Insect cuticle protein MFS_1 PF07690.16 ACT01567.1 - 7.5e-33 113.9 52.5 3.9e-25 88.5 33.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ACT01567.1 - 0.0033 16.4 12.5 0.0033 16.4 12.5 2.6 1 1 1 2 2 2 1 MFS_1 like family DUF1056 PF06341.11 ACT01567.1 - 0.0045 17.3 1.2 0.0045 17.3 1.2 3.3 4 0 0 4 4 4 1 Protein of unknown function (DUF1056) MFS_3 PF05977.13 ACT01567.1 - 0.31 9.4 19.8 0.022 13.2 12.2 2.3 1 1 1 2 2 2 0 Transmembrane secretion effector Trp_oprn_chp PF09534.10 ACT01567.1 - 3.1 7.6 11.0 0.043 13.6 1.6 2.4 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) OATP PF03137.20 ACT01567.1 - 3.9 5.6 18.0 1.5 7.0 3.5 3.1 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family HTH_18 PF12833.7 ACT01568.1 - 8e-22 77.3 0.8 1.8e-21 76.2 0.8 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01568.1 - 7.7e-18 64.1 0.3 2.4e-08 33.8 0.2 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT01568.1 - 7.1e-10 38.9 0.4 1.2e-09 38.1 0.4 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT01568.1 - 4.6e-07 29.4 0.6 8.1e-07 28.7 0.1 1.6 2 0 0 2 2 2 1 Cupin domain ARD PF03079.14 ACT01568.1 - 0.11 12.7 0.4 0.19 11.9 0.1 1.6 2 0 0 2 2 2 0 ARD/ARD' family GFO_IDH_MocA_C PF02894.17 ACT01569.1 - 1e-20 73.9 0.1 8.9e-20 70.8 0.1 2.2 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.22 ACT01569.1 - 3.3e-17 63.4 0.0 5.8e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ACT01569.1 - 0.0011 19.6 0.0 0.0018 18.9 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain UxaC PF02614.14 ACT01570.1 - 2.2e-213 709.2 0.0 2.5e-213 709.1 0.0 1.0 1 0 0 1 1 1 1 Glucuronate isomerase Mannitol_dh_C PF08125.13 ACT01571.1 - 1.3e-41 142.8 0.0 1.7e-41 142.3 0.0 1.2 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 ACT01571.1 - 3e-17 63.2 0.0 7.1e-17 62.0 0.0 1.7 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain GD_AH_C PF04295.13 ACT01572.1 - 2e-161 537.2 0.0 2.4e-161 536.9 0.0 1.1 1 0 0 1 1 1 1 D-galactarate dehydratase / Altronate hydrolase, C terminus SAF PF08666.12 ACT01572.1 - 4.4e-12 46.4 0.5 1.1e-11 45.1 0.5 1.7 1 0 0 1 1 1 1 SAF domain Ribosomal_S5 PF00333.20 ACT01572.1 - 0.1 12.6 0.1 0.29 11.1 0.1 1.8 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain Toprim_C_rpt PF13368.6 ACT01573.1 - 0.0044 17.0 0.0 0.008 16.1 0.0 1.4 1 0 0 1 1 1 1 Topoisomerase C-terminal repeat DUF525 PF04379.14 ACT01573.1 - 0.021 15.0 0.0 0.027 14.7 0.0 1.2 1 0 0 1 1 1 0 ApaG domain MFS_1 PF07690.16 ACT01574.1 - 3.7e-20 72.2 47.1 3.7e-20 72.2 47.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily FixQ PF05545.11 ACT01574.1 - 3.6 7.6 0.0 3.6 7.6 0.0 4.9 6 0 0 6 6 6 0 Cbb3-type cytochrome oxidase component FixQ FCD PF07729.12 ACT01575.1 - 2.6e-23 82.8 3.5 5.3e-23 81.8 3.5 1.5 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 ACT01575.1 - 3.9e-20 71.3 0.4 7.1e-20 70.4 0.4 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_20 PF12840.7 ACT01575.1 - 0.00018 21.5 0.1 0.00039 20.4 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_DeoR PF08220.12 ACT01575.1 - 0.0013 18.5 0.8 0.015 15.0 0.0 2.5 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.20 ACT01575.1 - 0.0047 17.2 0.0 0.01 16.2 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator HTH_11 PF08279.12 ACT01575.1 - 0.0065 16.4 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 HTH domain HTH_27 PF13463.6 ACT01575.1 - 0.0067 16.9 0.2 0.31 11.6 0.0 2.5 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_IclR PF09339.10 ACT01575.1 - 0.016 15.0 0.3 0.6 9.9 0.1 2.5 2 0 0 2 2 2 0 IclR helix-turn-helix domain MarR_2 PF12802.7 ACT01575.1 - 0.018 14.9 0.1 0.15 11.9 0.1 2.1 2 0 0 2 2 2 0 MarR family DUF4423 PF14394.6 ACT01575.1 - 0.029 14.1 0.3 0.085 12.6 0.0 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4423) TFIIE_alpha PF02002.17 ACT01575.1 - 0.034 14.0 0.0 0.15 12.0 0.0 2.0 3 0 0 3 3 3 0 TFIIE alpha subunit RP-C PF03428.13 ACT01575.1 - 0.052 13.2 0.7 0.09 12.4 0.0 1.7 2 0 0 2 2 2 0 Replication protein C N-terminal domain AKAP7_RIRII_bdg PF10470.9 ACT01575.1 - 1.2 9.3 4.7 1.4 9.1 3.1 1.9 2 0 0 2 2 2 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein Sigma70_r2 PF04542.14 ACT01576.1 - 7.3e-11 41.7 0.0 1.2e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT01576.1 - 2.9e-07 30.1 0.1 5.8e-07 29.1 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT01576.1 - 0.00083 18.8 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 SnoaL_2 PF12680.7 ACT01576.1 - 0.084 13.5 0.0 0.15 12.7 0.0 1.4 1 0 0 1 1 1 0 SnoaL-like domain HTH_23 PF13384.6 ACT01576.1 - 0.16 11.8 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DUF1845 PF08900.11 ACT01576.1 - 0.16 11.7 0.0 1.8 8.2 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1845) CMD PF02627.20 ACT01577.1 - 1.1e-19 70.2 0.7 2e-19 69.4 0.3 1.7 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family CRS1_YhbY PF01985.21 ACT01577.1 - 0.074 13.2 0.0 0.18 12.0 0.0 1.6 2 0 0 2 2 2 0 CRS1 / YhbY (CRM) domain MFS_1 PF07690.16 ACT01578.1 - 1.9e-26 92.8 47.1 2.4e-17 62.9 17.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 ACT01578.1 - 3.9e-18 65.1 29.9 4.3e-18 65.0 29.9 1.0 1 0 0 1 1 1 1 Transmembrane secretion effector DAO PF01266.24 ACT01579.1 - 1.3e-44 153.3 0.0 1.6e-44 153.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Rieske PF00355.26 ACT01579.1 - 7.8e-14 51.4 0.1 1.9e-13 50.2 0.1 1.7 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain NAD_binding_8 PF13450.6 ACT01579.1 - 1.3e-08 35.0 0.3 6.3e-08 32.7 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ACT01579.1 - 3.3e-08 33.2 0.0 7.9e-08 31.9 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ACT01579.1 - 4.3e-07 29.4 0.0 8.2e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 ACT01579.1 - 9.9e-07 28.2 0.4 1.8e-06 27.4 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ACT01579.1 - 1.6e-06 27.6 0.3 4.9e-05 22.7 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ACT01579.1 - 2.4e-06 27.2 2.0 1.2e-05 24.8 2.0 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ACT01579.1 - 3.6e-05 23.0 0.0 0.0029 16.7 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein Amino_oxidase PF01593.24 ACT01579.1 - 0.00041 19.8 0.1 0.075 12.3 0.2 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 ACT01579.1 - 0.00046 19.0 0.6 0.0037 16.0 0.4 2.3 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.22 ACT01579.1 - 0.00052 19.2 0.6 0.0012 18.0 0.6 1.6 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ACT01579.1 - 0.00094 18.5 0.0 0.002 17.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT01579.1 - 0.0038 17.7 0.8 0.0087 16.6 0.4 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ACT01579.1 - 0.0063 16.5 0.6 4.4 7.3 0.2 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Trp_halogenase PF04820.14 ACT01579.1 - 0.009 14.9 0.3 0.014 14.3 0.3 1.3 1 0 0 1 1 1 1 Tryptophan halogenase Spherulin4 PF12138.8 ACT01579.1 - 0.14 11.8 0.1 0.23 11.1 0.1 1.2 1 0 0 1 1 1 0 Spherulation-specific family 4 TetR_N PF00440.23 ACT01580.1 - 2.9e-15 55.8 0.0 6.6e-15 54.6 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_23 PF13384.6 ACT01580.1 - 0.1 12.4 0.0 0.28 11.0 0.1 1.7 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_1_2 PF13022.6 ACT01580.1 - 0.14 12.4 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase Isochorismatase PF00857.20 ACT01581.1 - 5.5e-39 134.1 0.1 6.2e-39 134.0 0.1 1.0 1 0 0 1 1 1 1 Isochorismatase family DUF1574 PF07611.11 ACT01581.1 - 0.2 11.0 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1574) MFS_1 PF07690.16 ACT01582.1 - 9.2e-54 182.7 45.2 4.7e-29 101.4 21.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01582.1 - 7.2e-18 64.7 32.2 2.4e-09 36.6 6.5 3.3 1 1 1 3 3 3 3 Sugar (and other) transporter MFS_1_like PF12832.7 ACT01582.1 - 3.5e-10 39.3 27.3 2.6e-07 29.8 16.5 2.7 1 1 2 3 3 3 2 MFS_1 like family LacY_symp PF01306.19 ACT01582.1 - 8.4e-07 28.1 22.2 1.2e-06 27.5 22.2 1.2 1 0 0 1 1 1 1 LacY proton/sugar symporter MFS_3 PF05977.13 ACT01582.1 - 1.3e-06 27.1 20.4 2.2e-06 26.3 20.1 1.4 1 1 0 1 1 1 1 Transmembrane secretion effector MFS_4 PF06779.14 ACT01582.1 - 0.18 11.0 24.2 0.95 8.7 24.2 2.1 1 1 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB TCR_zetazeta PF11628.8 ACT01582.1 - 0.22 11.2 2.4 0.7 9.6 2.4 1.8 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 zeta chain Semialdhyde_dh PF01118.24 ACT01583.1 - 2.3e-31 108.8 0.1 3.8e-31 108.0 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 ACT01583.1 - 1.4e-28 100.2 0.0 5e-28 98.4 0.0 1.9 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, dimerisation domain NAD_binding_10 PF13460.6 ACT01583.1 - 0.00016 21.7 0.1 0.0003 20.7 0.1 1.5 1 1 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 ACT01583.1 - 0.00023 21.3 0.1 0.0025 17.9 0.1 2.3 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Gp_dh_C PF02800.20 ACT01583.1 - 0.00027 20.6 0.0 0.00063 19.4 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain GFO_IDH_MocA PF01408.22 ACT01583.1 - 0.011 16.5 0.1 0.024 15.5 0.1 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Epimerase PF01370.21 ACT01583.1 - 0.037 13.5 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DXP_reductoisom PF02670.16 ACT01583.1 - 0.08 13.7 0.1 0.29 11.9 0.1 2.0 2 1 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Sacchrp_dh_NADP PF03435.18 ACT01583.1 - 0.18 12.1 0.3 0.6 10.4 0.3 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 2-Hacid_dh_C PF02826.19 ACT01584.1 - 2.1e-62 209.7 0.1 1.1e-61 207.3 0.0 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ACT01584.1 - 9.6e-15 54.4 0.0 1.2e-14 54.1 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ACT01584.1 - 1.2e-07 32.0 0.1 4.6e-07 30.1 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 ACT01584.1 - 0.008 16.7 0.0 0.069 13.7 0.0 2.1 2 0 0 2 2 2 1 XdhC Rossmann domain F420_oxidored PF03807.17 ACT01584.1 - 0.011 16.3 0.5 0.028 15.0 0.2 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 ACT01584.1 - 0.067 12.8 0.0 0.31 10.6 0.0 1.9 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DUF4440 PF14534.6 ACT01584.1 - 0.07 13.5 0.0 0.33 11.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4440) Drf_DAD PF06345.11 ACT01584.1 - 0.072 13.1 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 DRF Autoregulatory Domain DUF4097 PF13349.6 ACT01585.1 - 2.5e-24 86.0 25.4 8.8e-15 54.7 6.0 2.1 1 1 1 2 2 2 2 Putative adhesin NifU PF01106.17 ACT01585.1 - 0.017 15.3 0.0 9.4 6.5 0.0 3.1 3 1 0 3 3 3 0 NifU-like domain DUF1700 PF08006.11 ACT01586.1 - 2.3e-55 186.9 1.6 2.6e-55 186.8 1.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1700) Oleosin PF01277.17 ACT01586.1 - 0.14 12.0 11.1 0.21 11.3 11.1 1.3 1 0 0 1 1 1 0 Oleosin DUF1003 PF06210.11 ACT01586.1 - 0.54 10.4 1.6 0.96 9.6 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) FA_desaturase PF00487.24 ACT01586.1 - 8.1 6.2 7.2 2.3 8.0 4.2 1.5 1 1 0 1 1 1 0 Fatty acid desaturase PadR PF03551.14 ACT01587.1 - 1.6e-21 76.1 2.3 2.5e-21 75.4 2.0 1.4 1 1 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.6 ACT01587.1 - 0.00019 21.5 0.1 0.00024 21.2 0.1 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain HxlR PF01638.17 ACT01587.1 - 0.0057 16.5 0.1 0.0074 16.1 0.1 1.2 1 0 0 1 1 1 1 HxlR-like helix-turn-helix TrmB PF01978.19 ACT01587.1 - 0.017 15.0 0.2 0.029 14.2 0.2 1.6 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 ACT01587.1 - 0.045 14.2 0.0 0.069 13.7 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain Mrr_N PF14338.6 ACT01587.1 - 0.076 13.2 0.1 0.22 11.7 0.1 1.9 1 1 0 1 1 1 0 Mrr N-terminal domain Replic_Relax PF13814.6 ACT01587.1 - 0.079 13.0 0.0 0.091 12.8 0.0 1.1 1 0 0 1 1 1 0 Replication-relaxation Gluconate_2-dh3 PF13618.6 ACT01588.1 - 5.3e-35 120.6 0.3 8.9e-35 119.9 0.3 1.4 1 0 0 1 1 1 1 Gluconate 2-dehydrogenase subunit 3 TAT_signal PF10518.9 ACT01588.1 - 0.00069 19.4 0.4 0.0014 18.4 0.4 1.5 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.9 ACT01588.1 - 0.0012 18.1 0.0 0.0025 17.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DUF1091 PF06477.13 ACT01588.1 - 0.098 13.1 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) GMC_oxred_C PF05199.13 ACT01589.1 - 7.5e-20 71.9 0.0 1.4e-19 71.0 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 ACT01589.1 - 3.6e-11 43.0 0.0 2.3e-10 40.3 0.0 2.0 2 0 0 2 2 2 1 GMC oxidoreductase DAO PF01266.24 ACT01589.1 - 3.9e-05 23.4 0.0 0.0001 22.1 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ACT01589.1 - 0.002 17.5 0.5 0.03 13.6 0.4 2.1 2 0 0 2 2 2 1 FAD binding domain ApbA PF02558.16 ACT01589.1 - 0.034 13.8 0.1 0.034 13.8 0.1 2.2 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 ACT01589.1 - 0.039 13.2 0.0 6.5 5.9 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 ACT01589.1 - 0.16 11.3 0.0 0.34 10.3 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ACT01589.1 - 0.18 11.4 1.1 0.43 10.1 0.5 1.9 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Peptidase_U4 PF03419.13 ACT01589.1 - 0.24 10.7 0.0 0.55 9.5 0.0 1.5 2 0 0 2 2 2 0 Sporulation factor SpoIIGA TatC PF00902.18 ACT01590.1 - 1.3e-51 175.4 13.4 1.7e-51 175.0 13.4 1.1 1 0 0 1 1 1 1 Sec-independent protein translocase protein (TatC) FAM176 PF14851.6 ACT01590.1 - 0.53 9.9 3.3 7.5 6.2 0.1 3.0 3 0 0 3 3 3 0 FAM176 family DUF2085 PF09858.9 ACT01590.1 - 8.8 6.9 9.7 0.62 10.6 1.7 3.0 2 2 2 4 4 4 0 Predicted membrane protein (DUF2085) MttA_Hcf106 PF02416.16 ACT01591.1 - 3.3e-18 64.7 0.2 3.6e-18 64.6 0.2 1.1 1 0 0 1 1 1 1 mttA/Hcf106 family Cupredoxin_1 PF13473.6 ACT01592.1 - 2e-07 31.1 0.1 3.6e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 Cupredoxin-like domain COX2 PF00116.20 ACT01592.1 - 2.6e-05 24.1 0.0 3.4e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain Big_8 PF17961.1 ACT01592.1 - 0.0034 17.5 0.2 0.0064 16.6 0.2 1.4 1 0 0 1 1 1 1 Bacterial Ig domain TrbI PF03743.14 ACT01592.1 - 0.0039 17.0 3.3 0.0052 16.6 3.3 1.1 1 0 0 1 1 1 1 Bacterial conjugation TrbI-like protein Reeler PF02014.16 ACT01592.1 - 0.011 16.4 0.0 0.017 15.9 0.0 1.3 1 0 0 1 1 1 0 Reeler domain Copper-bind PF00127.20 ACT01592.1 - 0.017 15.5 2.8 0.057 13.9 1.3 2.3 1 1 1 2 2 2 0 Copper binding proteins, plastocyanin/azurin family ODV-E18 PF10717.9 ACT01592.1 - 0.28 11.1 3.9 0.45 10.4 3.7 1.5 1 1 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DNA_binding_1 PF01035.20 ACT01593.1 - 6.7e-32 109.5 0.0 1.1e-31 108.7 0.0 1.4 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.15 ACT01593.1 - 3.1e-05 24.7 0.0 5.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Methyltransf_11 PF08241.12 ACT01594.1 - 1.7e-27 95.9 0.0 3.2e-27 95.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT01594.1 - 1.8e-24 86.2 0.0 4.1e-24 85.1 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT01594.1 - 9.7e-19 67.8 0.0 1.4e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT01594.1 - 7.5e-18 64.8 0.0 9.1e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT01594.1 - 3.7e-16 59.7 0.0 5.7e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ACT01594.1 - 1.3e-14 54.1 0.0 1.8e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 ACT01594.1 - 2.4e-11 43.6 0.0 3.6e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_8 PF05148.15 ACT01594.1 - 1.7e-08 34.6 0.0 4.1e-08 33.3 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.16 ACT01594.1 - 2.2e-06 26.5 0.3 9.4e-06 24.5 0.3 1.8 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase CMAS PF02353.20 ACT01594.1 - 1.7e-05 24.3 0.0 1.9e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MetW PF07021.12 ACT01594.1 - 0.00013 21.7 0.0 0.0002 21.0 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 ACT01594.1 - 0.00013 21.6 0.0 0.00035 20.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_9 PF08003.11 ACT01594.1 - 0.017 14.0 0.0 0.031 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PCMT PF01135.19 ACT01594.1 - 0.018 14.8 0.0 0.029 14.1 0.0 1.5 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 ACT01594.1 - 0.022 14.2 0.7 0.7 9.3 0.7 2.8 1 1 0 1 1 1 0 Putative methyltransferase Methyltransf_15 PF09445.10 ACT01594.1 - 0.024 14.2 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase RrnaAD PF00398.20 ACT01594.1 - 0.04 13.0 0.0 0.055 12.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Bclx_interact PF08945.10 ACT01594.1 - 0.051 13.3 0.1 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 Bcl-x interacting, BH3 domain Bin3 PF06859.12 ACT01594.1 - 0.076 13.7 0.2 4 8.1 0.1 2.5 2 0 0 2 2 2 0 Bicoid-interacting protein 3 (Bin3) DUF309 PF03745.14 ACT01594.1 - 0.096 12.4 0.1 0.25 11.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF309) TPMT PF05724.11 ACT01594.1 - 0.13 11.9 0.8 0.31 10.7 0.0 2.0 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) DED PF01335.21 ACT01595.1 - 0.0056 16.9 3.9 0.0075 16.6 3.7 1.3 1 1 0 1 1 1 1 Death effector domain KxDL PF10241.9 ACT01595.1 - 0.021 15.1 3.2 0.028 14.7 3.2 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein Phage_tail_APC PF16778.5 ACT01595.1 - 0.046 13.6 0.3 0.079 12.8 0.3 1.6 1 1 0 1 1 1 0 Phage tail assembly chaperone protein TMPIT PF07851.13 ACT01595.1 - 0.074 12.3 2.7 0.077 12.2 2.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein Spc24 PF08286.11 ACT01595.1 - 0.22 11.8 4.1 0.35 11.1 4.1 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DMT_YdcZ PF04657.13 ACT01596.1 - 3.5e-27 95.4 14.5 3.9e-27 95.2 14.5 1.0 1 0 0 1 1 1 1 Putative inner membrane exporter, YdcZ EamA PF00892.20 ACT01596.1 - 0.01 16.0 12.0 0.017 15.3 12.0 1.4 1 1 0 1 1 1 0 EamA-like transporter family cNMP_binding PF00027.29 ACT01597.1 - 9.1e-15 54.5 0.0 1.7e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 ACT01597.1 - 3.4e-09 36.6 0.2 5.9e-09 35.8 0.2 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 ACT01597.1 - 0.13 12.6 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator DMT_YdcZ PF04657.13 ACT01598.1 - 2e-25 89.7 14.9 2.3e-25 89.5 14.9 1.0 1 0 0 1 1 1 1 Putative inner membrane exporter, YdcZ Cation_ATPase_C PF00689.21 ACT01598.1 - 9.4 5.9 10.0 1.5 8.5 4.8 1.9 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus AzlC PF03591.14 ACT01599.1 - 8.6e-41 139.6 15.4 8.6e-41 139.6 15.4 2.0 2 0 0 2 2 2 1 AzlC protein SYS1 PF09801.9 ACT01599.1 - 0.025 14.7 1.9 0.025 14.7 1.9 2.3 1 1 1 2 2 2 0 Integral membrane protein S linking to the trans Golgi network AzlD PF05437.12 ACT01600.1 - 7.5e-27 93.4 11.8 8.4e-27 93.3 11.8 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport protein (AzlD) DPM3 PF08285.11 ACT01600.1 - 0.86 9.8 4.2 2.1 8.6 4.2 1.8 1 1 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Syndecan PF01034.20 ACT01600.1 - 3.6 7.6 6.0 7.2 6.6 0.3 2.5 2 0 0 2 2 2 0 Syndecan domain Transgly PF00912.22 ACT01601.1 - 1.1e-63 213.9 1.8 3.2e-63 212.4 0.2 2.1 2 0 0 2 2 2 1 Transglycosylase Transpeptidase PF00905.22 ACT01601.1 - 2.1e-39 135.5 0.1 2.1e-39 135.5 0.1 2.3 2 1 0 2 2 1 1 Penicillin binding protein transpeptidase domain PHBC_N PF12551.8 ACT01601.1 - 0.033 14.0 0.1 0.074 12.8 0.1 1.6 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase N terminal DDHD PF02862.17 ACT01601.1 - 0.77 9.9 4.2 1.6 8.8 4.2 1.5 1 0 0 1 1 1 0 DDHD domain Auts2 PF15336.6 ACT01601.1 - 2.1 8.4 13.5 4.3 7.4 13.5 1.4 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein RR_TM4-6 PF06459.12 ACT01601.1 - 2.3 8.0 18.9 4.1 7.2 18.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 ACT01601.1 - 4.4 6.6 15.9 7.1 5.9 15.9 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Jak1_Phl PF17887.1 ACT01601.1 - 5.2 7.0 9.1 11 6.0 9.1 1.5 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain CDC45 PF02724.14 ACT01601.1 - 6.1 5.0 13.9 8.1 4.6 13.9 1.1 1 0 0 1 1 1 0 CDC45-like protein MDM31_MDM32 PF08118.11 ACT01601.1 - 7.3 5.1 6.7 11 4.6 6.7 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins PTPRCAP PF15713.5 ACT01601.1 - 8 6.7 14.7 17 5.7 14.7 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated U79_P34 PF03064.16 ACT01601.1 - 9.2 5.6 19.4 15 4.9 19.4 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DLH PF01738.18 ACT01602.1 - 6.5e-26 91.2 0.0 7.9e-26 91.0 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 ACT01602.1 - 0.00057 20.5 0.0 0.0007 20.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACT01602.1 - 0.02 14.2 0.1 0.034 13.4 0.1 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 ACT01602.1 - 0.044 12.8 0.0 0.055 12.5 0.0 1.1 1 0 0 1 1 1 0 Chlorophyllase ABC_tran PF00005.27 ACT01603.1 - 3.1e-40 137.9 6.3 4.2e-22 79.1 0.1 3.9 3 2 1 4 4 2 2 ABC transporter AAA_21 PF13304.6 ACT01603.1 - 6e-12 46.0 9.1 8.5e-06 25.8 0.0 4.4 3 2 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT01603.1 - 2.8e-07 30.2 5.2 0.0006 19.3 0.2 3.7 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT01603.1 - 4.3e-06 26.4 0.2 0.026 14.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ACT01603.1 - 2.2e-05 24.5 0.0 0.19 11.8 0.0 2.9 2 1 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ACT01603.1 - 2.3e-05 24.4 1.3 0.011 15.6 0.2 3.0 3 1 0 3 3 3 1 RsgA GTPase AAA_23 PF13476.6 ACT01603.1 - 0.0002 21.9 10.0 0.29 11.6 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 ACT01603.1 - 0.00024 21.5 0.0 0.32 11.4 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain NACHT PF05729.12 ACT01603.1 - 0.00095 19.1 0.0 1.2 9.1 0.0 2.5 2 0 0 2 2 2 2 NACHT domain RNA_helicase PF00910.22 ACT01603.1 - 0.00096 19.5 0.5 2.1 8.8 0.0 3.4 3 0 0 3 3 3 1 RNA helicase AAA_18 PF13238.6 ACT01603.1 - 0.0021 18.6 1.7 0.2 12.2 0.0 3.6 2 1 1 4 4 4 1 AAA domain Zeta_toxin PF06414.12 ACT01603.1 - 0.0023 17.2 0.0 9.4 5.4 0.1 3.2 2 1 1 3 3 3 0 Zeta toxin Dynamin_N PF00350.23 ACT01603.1 - 0.0025 17.9 6.9 0.021 14.9 0.0 3.8 2 1 0 3 3 3 1 Dynamin family AAA_22 PF13401.6 ACT01603.1 - 0.0026 18.1 0.0 1.5 9.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ACT01603.1 - 0.0045 16.2 0.0 1.1 8.4 0.0 2.7 2 1 0 2 2 2 1 NB-ARC domain NTPase_1 PF03266.15 ACT01603.1 - 0.0094 15.9 0.6 3.5 7.5 0.0 3.3 4 0 0 4 4 3 1 NTPase PduV-EutP PF10662.9 ACT01603.1 - 0.012 15.4 0.8 0.55 10.0 0.1 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 ACT01603.1 - 0.013 15.1 0.0 1.9 8.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 ACT01603.1 - 0.014 15.8 0.0 1.8 9.0 0.0 3.2 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ABC_tran_Xtn PF12848.7 ACT01603.1 - 0.022 14.8 9.3 0.13 12.3 9.2 2.2 1 1 1 2 2 2 0 ABC transporter TsaE PF02367.17 ACT01603.1 - 0.028 14.4 0.0 9.7 6.2 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SbcCD_C PF13558.6 ACT01603.1 - 0.039 14.2 0.0 11 6.4 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF4024 PF13216.6 ACT01603.1 - 0.041 13.8 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4024) MeaB PF03308.16 ACT01603.1 - 0.046 12.7 0.2 3 6.8 0.0 2.5 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 ACT01603.1 - 0.061 13.2 0.0 2.4 8.1 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B KAP_NTPase PF07693.14 ACT01603.1 - 0.092 12.0 4.4 2.8 7.1 0.0 2.7 2 1 0 2 2 2 0 KAP family P-loop domain AAA_15 PF13175.6 ACT01603.1 - 0.17 11.6 0.2 0.17 11.6 0.2 3.7 2 2 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 ACT01603.1 - 0.21 11.3 3.7 11 5.6 0.1 3.2 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 ACT01603.1 - 2.3 8.2 7.0 8.2 6.4 0.1 3.4 3 1 0 3 3 3 0 Helicase HerA, central domain AAA_19 PF13245.6 ACT01604.1 - 8.8e-10 39.1 0.1 4e-08 33.7 0.0 2.9 2 1 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 ACT01604.1 - 2.7e-08 33.5 0.0 6.3e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 ACT01604.1 - 4.8e-08 32.9 14.0 7.3e-06 25.7 3.8 2.7 3 0 0 3 3 3 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ACT01604.1 - 1.6e-07 31.0 8.2 0.00061 19.3 0.0 3.9 2 2 1 3 3 3 2 UvrD-like helicase C-terminal domain PhoH PF02562.16 ACT01604.1 - 0.0001 21.8 0.0 0.055 12.9 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein Viral_helicase1 PF01443.18 ACT01604.1 - 0.00013 21.8 0.0 0.46 10.2 0.0 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 ACT01604.1 - 0.0035 16.6 0.0 0.025 13.9 0.0 2.4 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 ACT01604.1 - 0.0062 16.3 0.0 0.019 14.8 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ACT01604.1 - 0.03 14.6 0.0 13 6.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 ACT01604.1 - 0.041 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain CdiI PF07262.11 ACT01604.1 - 0.062 13.1 0.4 0.27 11.0 0.5 2.0 2 0 0 2 2 2 0 CDI immunity protein GED PF02212.18 ACT01604.1 - 0.14 12.3 0.9 0.51 10.5 0.2 2.3 2 0 0 2 2 2 0 Dynamin GTPase effector domain AAA_16 PF13191.6 ACT01604.1 - 0.14 12.5 0.6 0.47 10.8 0.0 2.2 3 0 0 3 3 3 0 AAA ATPase domain ResIII PF04851.15 ACT01604.1 - 0.22 11.5 1.7 0.67 9.9 0.0 2.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Seryl_tRNA_N PF02403.22 ACT01604.1 - 3.6 7.9 6.2 6.2 7.1 0.0 3.2 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain LysR_substrate PF03466.20 ACT01605.1 - 2.4e-37 128.3 0.1 3.5e-37 127.8 0.1 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01605.1 - 2.6e-20 72.1 0.6 5.3e-20 71.1 0.6 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR_2 PF12802.7 ACT01605.1 - 0.075 12.9 0.2 0.18 11.7 0.2 1.6 1 0 0 1 1 1 0 MarR family COesterase PF00135.28 ACT01606.1 - 5.7e-101 338.9 0.0 1.5e-100 337.5 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ACT01606.1 - 4.6e-11 43.0 3.1 8.3e-07 29.1 0.3 2.6 2 1 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ACT01606.1 - 2.8e-05 23.7 0.1 4.7e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family TauE PF01925.19 ACT01607.1 - 3.8e-36 124.9 44.5 4.5e-36 124.7 44.5 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Isochorismatase PF00857.20 ACT01608.1 - 8.3e-39 133.6 0.0 9.5e-39 133.4 0.0 1.0 1 0 0 1 1 1 1 Isochorismatase family AXE1 PF05448.12 ACT01609.1 - 5.7e-79 265.1 0.0 6.4e-79 264.9 0.0 1.0 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 ACT01609.1 - 2e-11 43.8 0.1 3.1e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 ACT01609.1 - 0.00058 19.8 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ACT01609.1 - 0.0039 16.5 0.2 1.4 8.1 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ACT01609.1 - 0.013 16.1 0.2 0.028 15.0 0.2 1.5 1 1 1 2 2 2 0 Alpha/beta hydrolase family BAAT_C PF08840.11 ACT01609.1 - 0.02 14.8 0.0 0.045 13.7 0.0 1.5 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal PAF-AH_p_II PF03403.13 ACT01609.1 - 0.024 13.2 0.1 0.27 9.7 0.0 2.0 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DLH PF01738.18 ACT01609.1 - 0.11 12.0 0.1 1.2 8.7 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family adh_short_C2 PF13561.6 ACT01610.1 - 1.8e-62 210.9 11.0 2.1e-62 210.8 11.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT01610.1 - 1.2e-53 181.5 9.8 1.4e-53 181.3 9.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT01610.1 - 6.1e-06 26.3 3.2 6.1e-06 26.3 3.2 1.5 2 0 0 2 2 2 1 KR domain 3HCDH_N PF02737.18 ACT01610.1 - 0.019 14.9 1.0 0.032 14.1 1.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 ACT01610.1 - 0.37 10.2 2.8 0.47 9.9 0.3 2.1 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family TetR_C_8 PF14278.6 ACT01611.1 - 3.8e-14 52.6 0.5 6.7e-14 51.9 0.2 1.5 2 0 0 2 2 2 1 Transcriptional regulator C-terminal region TetR_N PF00440.23 ACT01611.1 - 9.5e-05 22.1 0.0 0.00022 20.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Novirhabdo_Nv PF05554.11 ACT01611.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Viral hemorrhagic septicemia virus non-virion protein Pentapeptide PF00805.22 ACT01612.1 - 3.1e-25 87.4 12.0 2.5e-08 33.4 0.0 5.2 2 2 4 6 6 6 6 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ACT01612.1 - 2.8e-22 78.7 4.3 5.1e-09 36.2 0.4 3.2 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ACT01612.1 - 2e-12 47.1 11.0 0.001 19.2 3.7 4.8 2 2 0 3 3 3 3 Pentapeptide repeats (9 copies) DUF4131 PF13567.6 ACT01613.1 - 0.017 14.7 0.3 0.019 14.6 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) TspO_MBR PF03073.15 ACT01613.1 - 0.018 15.1 1.2 0.025 14.6 1.2 1.2 1 0 0 1 1 1 0 TspO/MBR family Virul_fac_BrkB PF03631.15 ACT01613.1 - 0.019 14.6 0.2 0.023 14.3 0.2 1.0 1 0 0 1 1 1 0 Virulence factor BrkB CRA PF06589.11 ACT01613.1 - 0.68 10.0 2.2 5.5 7.1 0.0 2.1 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) Spore_permease PF03845.13 ACT01614.1 - 3.7e-49 167.3 31.3 4.8e-49 166.9 31.3 1.1 1 0 0 1 1 1 1 Spore germination protein DUF805 PF05656.14 ACT01614.1 - 0.054 13.9 0.9 0.054 13.9 0.9 4.1 2 1 0 2 2 2 0 Protein of unknown function (DUF805) GerA PF03323.13 ACT01615.1 - 1.4e-131 439.2 4.5 1.8e-131 438.9 4.5 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_GerAC PF05504.11 ACT01616.1 - 3e-32 112.1 3.3 4.9e-32 111.4 3.3 1.3 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal AAA_15 PF13175.6 ACT01616.1 - 0.017 14.8 3.3 0.019 14.7 3.3 1.2 1 0 0 1 1 1 0 AAA ATPase domain Herpes_US9 PF06072.11 ACT01617.1 - 0.014 15.3 1.0 0.015 15.1 1.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Col_cuticle_N PF01484.17 ACT01617.1 - 0.083 13.0 2.8 0.099 12.7 2.8 1.1 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain Rrf2 PF02082.20 ACT01618.1 - 1.4e-25 89.5 0.0 1.9e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator MarR_2 PF12802.7 ACT01618.1 - 4.1e-08 33.0 0.0 6.4e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 MarR family MarR PF01047.22 ACT01618.1 - 7e-06 25.9 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 ACT01618.1 - 0.00027 20.9 0.0 0.00044 20.2 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 ACT01618.1 - 0.00056 19.4 0.0 0.00095 18.7 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_27 PF13463.6 ACT01618.1 - 0.003 18.0 0.0 0.0062 17.0 0.0 1.5 1 1 0 1 1 1 1 Winged helix DNA-binding domain HrcA_DNA-bdg PF03444.15 ACT01618.1 - 0.012 15.3 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding RP-C PF03428.13 ACT01618.1 - 0.012 15.2 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 Replication protein C N-terminal domain GntR PF00392.21 ACT01618.1 - 0.013 15.2 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_5 PF01022.20 ACT01618.1 - 0.024 14.5 0.1 0.048 13.5 0.0 1.5 2 0 0 2 2 1 0 Bacterial regulatory protein, arsR family TrmB PF01978.19 ACT01618.1 - 0.034 14.0 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 ACT01618.1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_20 PF12840.7 ACT01618.1 - 0.057 13.5 0.1 0.13 12.4 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain AbiEi_4 PF13338.6 ACT01618.1 - 0.058 13.6 0.0 0.096 12.9 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin HTH_10 PF04967.12 ACT01618.1 - 0.067 13.0 0.0 0.37 10.6 0.0 2.0 2 0 0 2 2 2 0 HTH DNA binding domain HTH_CodY PF08222.11 ACT01618.1 - 0.073 12.6 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain Fe_dep_repress PF01325.19 ACT01618.1 - 0.11 12.7 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_3 PF01381.22 ACT01618.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix Pyr_redox_2 PF07992.14 ACT01619.1 - 2.1e-20 73.1 0.0 1.4e-18 67.2 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ACT01619.1 - 1.3e-08 34.3 0.6 4.9e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 ACT01619.1 - 1.6e-07 30.4 0.1 1.3e-05 24.1 0.0 2.3 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 ACT01619.1 - 6.4e-07 28.9 0.2 0.021 14.1 0.1 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT01619.1 - 1.7e-06 27.9 0.4 9.8e-05 22.1 0.2 2.3 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ACT01619.1 - 0.00013 22.0 0.1 0.47 10.4 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_2 PF03446.15 ACT01619.1 - 0.00016 21.9 1.2 0.077 13.2 0.0 3.3 3 1 0 4 4 4 1 NAD binding domain of 6-phosphogluconate dehydrogenase FAD_binding_3 PF01494.19 ACT01619.1 - 0.00019 20.8 0.0 0.00036 19.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ACT01619.1 - 0.00035 20.8 0.1 0.0009 19.4 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 ACT01619.1 - 0.00035 19.8 1.4 0.02 14.0 0.6 2.6 1 1 1 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 ACT01619.1 - 0.0053 16.0 0.1 0.0087 15.3 0.1 1.3 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 ACT01619.1 - 0.0067 15.7 0.2 0.013 14.8 0.1 1.4 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 ACT01619.1 - 0.0099 15.0 1.1 0.09 11.8 0.8 2.1 1 1 1 2 2 2 1 Lycopene cyclase protein FAD_oxidored PF12831.7 ACT01619.1 - 0.028 13.8 0.5 0.028 13.8 0.5 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 ACT01619.1 - 0.047 14.3 0.0 0.22 12.1 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ACT01619.1 - 0.12 11.2 0.2 0.38 9.5 0.2 1.8 2 0 0 2 2 2 0 Tryptophan halogenase zf-Di19 PF05605.12 ACT01619.1 - 0.22 11.8 0.2 0.45 10.8 0.2 1.5 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Ion_trans_2 PF07885.16 ACT01620.1 - 7.4e-15 54.7 15.2 1.2e-14 54.0 15.2 1.3 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 ACT01620.1 - 1.5e-10 40.8 7.7 2.1e-10 40.3 7.7 1.2 1 0 0 1 1 1 1 Ion transport protein TrkA_N PF02254.18 ACT01620.1 - 2.9e-10 40.4 0.0 4.6e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain DUF356 PF04009.12 ACT01620.1 - 0.12 12.7 1.1 2.4 8.5 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF356) Wzz PF02706.15 ACT01620.1 - 2.7 8.3 6.8 0.33 11.3 0.6 2.5 1 1 2 3 3 3 0 Chain length determinant protein Methyltransf_11 PF08241.12 ACT01621.1 - 9.8e-16 58.2 0.0 1.4e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT01621.1 - 1.3e-13 51.4 0.0 2.1e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 ACT01621.1 - 1.8e-11 44.1 0.0 8.1e-10 38.7 0.0 2.1 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_23 PF13489.6 ACT01621.1 - 2.9e-11 43.5 0.0 3.8e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT01621.1 - 1.8e-05 25.4 0.0 4.6e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT01621.1 - 3.2e-05 23.8 0.0 9.7e-05 22.2 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain CMAS PF02353.20 ACT01621.1 - 0.0073 15.6 0.0 0.014 14.7 0.0 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 ACT01621.1 - 0.0094 15.4 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB N2227 PF07942.12 ACT01621.1 - 0.029 13.5 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 N2227-like protein Ubie_methyltran PF01209.18 ACT01621.1 - 0.036 13.4 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_PK PF05891.12 ACT01621.1 - 0.13 11.8 0.0 0.18 11.3 0.0 1.3 1 1 0 1 1 1 0 AdoMet dependent proline di-methyltransferase DAO PF01266.24 ACT01622.1 - 2.3e-50 172.2 1.7 2.6e-50 172.0 1.7 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ACT01622.1 - 6e-08 32.2 2.5 1.1e-07 31.3 2.5 1.4 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ACT01622.1 - 1.8e-06 28.1 1.1 4.5e-06 26.8 0.1 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 ACT01622.1 - 3.3e-05 23.8 0.1 5.3e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 ACT01622.1 - 6.2e-05 22.4 0.3 0.00077 18.8 0.3 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ACT01622.1 - 9.5e-05 21.8 0.1 0.00023 20.5 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 ACT01622.1 - 0.0002 20.5 0.6 0.00039 19.6 0.6 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 ACT01622.1 - 0.00052 20.5 0.4 0.0013 19.2 0.4 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 ACT01622.1 - 0.00095 18.8 0.5 0.0019 17.8 0.1 1.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 ACT01622.1 - 0.0011 18.6 0.4 0.0019 17.8 0.4 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 ACT01622.1 - 0.0012 18.3 0.1 0.0015 17.9 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ACT01622.1 - 0.0052 16.1 0.0 0.0098 15.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ACT01622.1 - 0.0059 15.4 0.5 0.0086 14.8 0.5 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_7 PF13241.6 ACT01622.1 - 0.0065 16.9 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 ACT01622.1 - 0.0082 16.4 0.1 0.019 15.2 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 ACT01622.1 - 0.013 15.7 0.2 0.04 14.2 0.2 1.8 1 0 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 ACT01622.1 - 0.016 14.6 0.1 0.024 13.9 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 ACT01622.1 - 0.02 15.5 1.3 0.049 14.2 0.2 2.2 3 0 0 3 3 2 0 NADP oxidoreductase coenzyme F420-dependent Thi4 PF01946.17 ACT01622.1 - 0.036 13.3 0.3 0.036 13.3 0.3 2.2 2 0 0 2 2 2 0 Thi4 family adh_short PF00106.25 ACT01622.1 - 0.059 12.8 0.6 0.098 12.1 0.6 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Shikimate_DH PF01488.20 ACT01622.1 - 0.068 13.2 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 ACT01622.1 - 0.071 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 ACT01622.1 - 0.081 12.3 1.0 0.19 11.0 0.1 2.0 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ACT01622.1 - 0.17 11.4 0.3 0.31 10.6 0.3 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DUF1188 PF06690.11 ACT01622.1 - 0.26 10.8 0.1 0.37 10.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) PhyH PF05721.13 ACT01623.1 - 2.3e-38 132.6 0.2 3.1e-38 132.2 0.2 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HTH_18 PF12833.7 ACT01624.1 - 4.4e-20 71.7 0.1 7.3e-20 71.0 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01624.1 - 2.3e-12 46.7 0.0 5.3e-06 26.4 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT01624.1 - 1.2e-10 41.0 1.1 2.4e-10 40.0 0.7 1.7 2 0 0 2 2 2 1 Cupin domain AraC_binding PF02311.19 ACT01624.1 - 4.8e-10 39.5 1.4 9.4e-10 38.5 1.4 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_7 PF12973.7 ACT01624.1 - 0.00011 22.0 0.4 0.00024 21.0 0.4 1.5 1 0 0 1 1 1 1 ChrR Cupin-like domain Ectoine_synth PF06339.12 ACT01624.1 - 0.00012 22.3 0.2 0.00019 21.6 0.2 1.3 1 0 0 1 1 1 1 Ectoine synthase Cupin_3 PF05899.12 ACT01624.1 - 0.00066 19.3 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF861) DUF4437 PF14499.6 ACT01624.1 - 0.0028 16.8 0.1 0.0046 16.1 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4437) TFIIE_beta PF02186.15 ACT01624.1 - 0.036 14.3 0.1 0.14 12.4 0.0 1.9 2 0 0 2 2 2 0 TFIIE beta subunit core domain DMSP_lyase PF16867.5 ACT01624.1 - 0.039 13.6 0.3 0.086 12.5 0.2 1.6 2 0 0 2 2 2 0 Dimethlysulfonioproprionate lyase Glyco_hydro_43 PF04616.14 ACT01625.1 - 6.8e-31 107.6 1.6 9.5e-31 107.2 1.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 His_kinase PF06580.13 ACT01626.1 - 5.1e-22 78.0 1.9 9.3e-22 77.2 0.1 2.3 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT01626.1 - 2.4e-15 57.0 5.0 3.8e-15 56.4 5.0 1.3 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT01626.1 - 6e-10 39.6 0.0 1.6e-09 38.3 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT01626.1 - 4.5e-07 30.2 0.2 4.5e-07 30.2 0.2 1.7 2 0 0 2 2 2 1 HAMP domain DUF2620 PF10941.8 ACT01626.1 - 0.04 14.1 0.1 0.087 13.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF2620 HATPase_c_3 PF13589.6 ACT01626.1 - 0.076 12.8 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GrpE PF01025.19 ACT01626.1 - 0.086 12.5 0.1 0.22 11.2 0.1 1.7 1 0 0 1 1 1 0 GrpE Response_reg PF00072.24 ACT01627.1 - 5e-23 81.4 0.2 1.3e-22 80.0 0.0 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT01627.1 - 8.2e-18 64.5 0.1 3e-17 62.7 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01627.1 - 6.9e-13 48.3 0.0 1.7e-05 24.8 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT01627.1 - 5.1e-09 36.4 0.1 1.2e-08 35.2 0.1 1.6 1 0 0 1 1 1 1 GGDEF-like domain BPD_transp_1 PF00528.22 ACT01628.1 - 3.2e-07 30.3 22.0 3.2e-07 30.3 22.0 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT01629.1 - 5.3e-05 23.0 29.7 0.00042 20.1 29.7 2.0 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACT01630.1 - 2.5e-14 53.8 0.3 2.5e-14 53.8 0.3 1.9 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein DUF3863 PF12979.7 ACT01631.1 - 0.0068 15.3 0.1 0.01 14.7 0.1 1.2 1 0 0 1 1 1 1 Domain of Unknown Function with PDB structure (DUF3863) HTH_18 PF12833.7 ACT01632.1 - 2.1e-24 85.6 1.1 2.1e-24 85.6 1.1 1.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01632.1 - 3.6e-21 74.7 0.1 2.4e-09 37.1 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT01632.1 - 8.9e-10 38.6 0.1 1.6e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT01632.1 - 5.1e-06 26.1 0.7 9.3e-06 25.3 0.7 1.4 1 0 0 1 1 1 1 Cupin domain ARD PF03079.14 ACT01632.1 - 0.00038 20.7 0.2 0.00088 19.5 0.2 1.6 1 0 0 1 1 1 1 ARD/ARD' family DUF5484 PF17583.2 ACT01632.1 - 0.14 11.9 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5484) Bac_rhamnosid6H PF17389.2 ACT01633.1 - 1.2e-127 425.8 1.4 1.9e-127 425.3 1.4 1.3 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 ACT01633.1 - 4.5e-65 218.7 1.3 1e-64 217.5 1.3 1.6 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 ACT01633.1 - 2.8e-30 104.3 0.0 6.3e-30 103.2 0.0 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_C PF17390.2 ACT01633.1 - 1.9e-19 69.2 0.0 1.9e-18 66.0 0.0 2.5 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase C-terminal domain TFR_dimer PF04253.15 ACT01633.1 - 0.00046 20.3 0.0 1.5 8.9 0.0 2.7 2 0 0 2 2 2 2 Transferrin receptor-like dimerisation domain Il2rg PF15874.5 ACT01633.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Putative Interleukin 2 receptor, gamma chain Catalase PF00199.19 ACT01634.1 - 3.4e-128 428.0 0.0 4.7e-128 427.6 0.0 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ACT01634.1 - 5.6e-16 58.5 0.0 9.9e-16 57.7 0.0 1.4 1 0 0 1 1 1 1 Catalase-related immune-responsive YolD PF08863.10 ACT01635.1 - 5.4e-10 39.2 0.0 5.9e-10 39.1 0.0 1.0 1 0 0 1 1 1 1 YolD-like protein LysR_substrate PF03466.20 ACT01636.1 - 3e-34 118.2 0.0 4.3e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01636.1 - 1.6e-18 66.4 0.0 3.2e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 ACT01636.1 - 4.5e-05 23.2 0.0 0.0001 22.0 0.0 1.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_24 PF13412.6 ACT01636.1 - 0.049 13.2 0.0 0.14 11.8 0.0 1.8 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF2093 PF09866.9 ACT01636.1 - 0.13 11.7 0.2 16 5.1 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2093) MarR PF01047.22 ACT01636.1 - 0.15 12.0 0.1 0.38 10.7 0.1 1.7 1 0 0 1 1 1 0 MarR family M20_dimer PF07687.14 ACT01637.1 - 5.5e-11 42.4 0.0 1.2e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ACT01637.1 - 2.3e-09 37.3 0.5 3.6e-09 36.6 0.5 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DcuC PF03606.15 ACT01638.1 - 1.3e-102 343.7 32.7 1.4e-102 343.5 32.7 1.0 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier SCFA_trans PF02667.14 ACT01638.1 - 4.5e-07 29.2 10.3 4.5e-07 29.2 10.3 2.0 2 1 1 3 3 3 1 Short chain fatty acid transporter Na_H_antiporter PF03553.14 ACT01638.1 - 7.1e-07 28.7 14.9 7.1e-07 28.7 14.9 2.2 1 1 1 2 2 2 1 Na+/H+ antiporter family ABG_transport PF03806.13 ACT01638.1 - 3.1e-06 25.7 29.9 0.00034 19.0 29.9 2.4 1 1 0 1 1 1 1 AbgT putative transporter family DUF3040 PF11239.8 ACT01638.1 - 3.4 8.0 0.0 3.4 8.0 0.0 4.8 4 1 1 5 5 5 0 Protein of unknown function (DUF3040) MR_MLE_C PF13378.6 ACT01639.1 - 8.6e-70 234.7 0.1 1.1e-69 234.3 0.1 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ACT01639.1 - 2.5e-27 95.4 0.0 4.8e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain PEP_mutase PF13714.6 ACT01639.1 - 0.0034 16.9 0.2 0.0059 16.1 0.2 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase HAD_2 PF13419.6 ACT01640.1 - 2.8e-27 95.9 0.0 4.4e-27 95.3 0.0 1.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT01640.1 - 8e-13 49.1 0.0 7.2e-12 46.0 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT01640.1 - 4.2e-10 39.5 0.0 8.6e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ACT01640.1 - 2.8e-06 27.9 0.6 7.5e-06 26.5 0.6 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 ACT01640.1 - 0.0008 19.1 0.0 0.014 15.1 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase PNK3P PF08645.11 ACT01640.1 - 0.004 16.9 0.0 2.2 7.9 0.0 3.0 2 1 0 2 2 2 1 Polynucleotide kinase 3 phosphatase NIF PF03031.18 ACT01640.1 - 0.028 14.2 0.0 6.2 6.6 0.0 2.2 2 0 0 2 2 2 0 NLI interacting factor-like phosphatase Hydrolase_3 PF08282.12 ACT01640.1 - 0.077 12.7 0.0 14 5.3 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 ACT01640.1 - 0.12 12.0 0.6 0.92 9.0 0.3 2.3 2 1 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Beta_helix PF13229.6 ACT01641.1 - 8.6e-08 32.2 0.0 9e-06 25.6 0.0 3.3 2 2 0 2 2 2 1 Right handed beta helix region NosD PF05048.13 ACT01641.1 - 0.00089 18.6 0.0 0.0055 16.0 0.0 2.2 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Cass2 PF14526.6 ACT01641.1 - 0.089 13.0 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Integron-associated effector binding protein Glyco_hydro_2_C PF02836.17 ACT01642.1 - 2.6e-45 154.8 0.0 3.6e-45 154.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 ACT01642.1 - 7.1e-16 58.6 0.1 5.1e-15 55.8 0.1 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 ACT01642.1 - 9.8e-09 35.9 0.0 1.6e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_cc PF11790.8 ACT01642.1 - 0.0066 16.0 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Fn3-like PF14310.6 ACT01642.1 - 0.019 15.1 0.0 0.056 13.6 0.0 1.8 2 0 0 2 2 2 0 Fibronectin type III-like domain HTH_18 PF12833.7 ACT01643.1 - 1.8e-20 72.9 0.0 3e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01643.1 - 5.7e-19 67.7 0.4 6.2e-10 38.9 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT01643.1 - 1.8e-06 27.9 0.0 2.8e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Rrf2 PF02082.20 ACT01643.1 - 0.034 14.5 0.1 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 Transcriptional regulator Cupin_2 PF07883.11 ACT01643.1 - 0.053 13.2 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 Cupin domain DUF11 PF01345.18 ACT01644.1 - 5.6e-79 260.6 73.0 1.2e-10 41.6 0.1 11.1 10 1 0 10 10 10 10 Domain of unknown function DUF11 NPCBM_assoc PF10633.9 ACT01644.1 - 1.8e-13 50.5 54.6 0.018 15.3 0.8 15.6 17 1 0 17 17 17 5 NPCBM-associated, NEW3 domain of alpha-galactosidase CARDB PF07705.11 ACT01644.1 - 6.7e-12 45.6 46.5 0.091 13.0 0.5 11.1 10 1 2 12 12 11 6 CARDB Arrestin_C PF02752.22 ACT01644.1 - 5.6e-07 30.1 12.2 0.32 11.5 0.0 8.5 7 1 0 8 8 8 1 Arrestin (or S-antigen), C-terminal domain TRAP_beta PF05753.14 ACT01644.1 - 5.6e-06 25.9 13.4 0.6 9.5 0.0 7.7 7 1 1 8 8 8 2 Translocon-associated protein beta (TRAPB) CusF_Ec PF11604.8 ACT01644.1 - 9.9e-06 25.4 0.3 15 5.6 0.0 7.1 8 0 0 8 8 7 0 Copper binding periplasmic protein CusF N_BRCA1_IG PF16158.5 ACT01644.1 - 2.8e-05 24.8 0.1 58 4.5 0.0 7.0 7 0 0 7 7 7 0 Ig-like domain from next to BRCA1 gene DUF1573 PF07610.11 ACT01644.1 - 0.00066 19.7 10.7 12 5.9 0.0 7.9 9 0 0 9 9 9 1 Protein of unknown function (DUF1573) bMG10 PF17973.1 ACT01644.1 - 0.0041 17.3 3.0 3.7 7.7 0.0 5.5 6 0 0 6 6 6 1 Bacterial Alpha-2-macroglobulin MG10 domain DUF824 PF05688.11 ACT01644.1 - 0.02 14.7 0.5 0.02 14.7 0.5 7.5 9 0 0 9 9 9 0 Salmonella repeat of unknown function (DUF824) BsuPI PF12690.7 ACT01644.1 - 0.06 13.4 6.7 38 4.4 0.1 5.9 7 0 0 7 7 7 0 Intracellular proteinase inhibitor A2M PF00207.22 ACT01644.1 - 0.14 12.1 7.7 3.1 7.7 0.3 4.7 5 0 0 5 5 5 0 Alpha-2-macroglobulin family FKBP_C PF00254.28 ACT01644.1 - 0.14 12.5 0.0 92 3.5 0.0 4.4 2 1 1 3 3 3 0 FKBP-type peptidyl-prolyl cis-trans isomerase CtaG_Cox11 PF04442.14 ACT01644.1 - 0.29 11.2 1.7 6.4 6.8 0.0 4.0 5 0 0 5 5 5 0 Cytochrome c oxidase assembly protein CtaG/Cox11 SdrD_B PF17210.3 ACT01645.1 - 2.6e-14 53.4 0.1 5e-12 46.0 0.0 3.0 2 0 0 2 2 2 1 SdrD B-like domain DUF4394 PF14339.6 ACT01645.1 - 5.1e-08 32.6 5.0 0.024 14.0 0.1 4.5 2 1 2 4 4 4 3 Domain of unknown function (DUF4394) DUF11 PF01345.18 ACT01645.1 - 1.1e-06 28.9 1.5 0.00011 22.4 0.0 3.6 3 0 0 3 3 3 1 Domain of unknown function DUF11 CarboxypepD_reg PF13620.6 ACT01645.1 - 0.00017 21.8 0.9 0.00017 21.8 0.9 2.8 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain Tachylectin PF14517.6 ACT01645.1 - 0.0015 18.1 0.0 0.015 14.8 0.0 2.2 1 1 0 1 1 1 1 Tachylectin DUF5300 PF17224.3 ACT01645.1 - 0.0076 16.5 0.1 0.22 11.8 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF5300) Big_1 PF02369.16 ACT01645.1 - 0.0085 16.1 2.0 0.13 12.3 0.3 3.3 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 1) SpaA PF17802.1 ACT01645.1 - 0.022 15.1 0.2 0.11 12.8 0.1 2.4 2 0 0 2 2 2 0 Prealbumin-like fold domain Invasin_D3 PF09134.10 ACT01645.1 - 1.3 9.4 18.4 1.2 9.4 0.9 4.1 3 1 1 4 4 4 0 Invasin, domain 3 Urate_ox_N PF06181.11 ACT01647.1 - 0.03 13.7 0.1 0.03 13.7 0.1 1.1 1 0 0 1 1 1 0 Urate oxidase N-terminal HTH_5 PF01022.20 ACT01648.1 - 1.1e-12 47.6 1.6 2.5e-10 40.1 0.2 2.1 2 0 0 2 2 2 2 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACT01648.1 - 2e-07 31.0 1.0 2.7e-07 30.5 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 ACT01648.1 - 0.00055 19.8 0.0 0.001 18.9 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT01648.1 - 0.0035 16.9 0.1 0.019 14.5 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.10 ACT01648.1 - 0.0057 16.4 0.2 0.011 15.5 0.2 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain Acetyltransf_16 PF05301.11 ACT01648.1 - 0.068 12.9 0.0 0.083 12.7 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 HTH_34 PF13601.6 ACT01648.1 - 0.091 12.9 0.1 0.32 11.2 0.0 1.8 2 0 0 2 2 2 0 Winged helix DNA-binding domain HTH_11 PF08279.12 ACT01648.1 - 0.13 12.2 0.0 0.53 10.3 0.0 1.9 2 0 0 2 2 2 0 HTH domain CW_binding_1 PF01473.20 ACT01648.1 - 0.14 12.5 0.7 0.3 11.5 0.7 1.5 1 0 0 1 1 1 0 Putative cell wall binding repeat Epimerase PF01370.21 ACT01649.1 - 1.5e-22 80.3 0.0 2.1e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ACT01649.1 - 2.7e-17 62.7 0.0 3.6e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ACT01649.1 - 8.5e-10 38.8 0.0 1.3e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ACT01649.1 - 3.2e-09 36.6 0.0 1.1e-08 34.9 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ACT01649.1 - 1.2e-05 24.6 0.0 3.1e-05 23.3 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 ACT01649.1 - 0.0015 18.1 0.3 0.21 11.1 0.3 2.7 2 1 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 ACT01649.1 - 0.0044 16.2 0.0 0.0069 15.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 ACT01649.1 - 0.1 12.5 0.0 10 6.0 0.0 2.4 2 0 0 2 2 2 0 KR domain adh_short PF00106.25 ACT01649.1 - 0.14 11.6 0.0 0.44 10.0 0.0 1.7 2 0 0 2 2 2 0 short chain dehydrogenase Acetyltransf_10 PF13673.7 ACT01650.1 - 1.9e-11 44.0 0.1 2.3e-11 43.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT01650.1 - 6e-09 36.2 0.0 7.4e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT01650.1 - 6.8e-08 32.8 0.2 1.6e-07 31.7 0.1 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain NAT PF04768.13 ACT01650.1 - 0.00053 19.7 0.0 0.00058 19.6 0.0 1.1 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Acetyltransf_3 PF13302.7 ACT01650.1 - 0.0049 17.6 0.0 0.0062 17.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT01650.1 - 0.016 15.2 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.6 ACT01650.1 - 0.074 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase SBP_bac_5 PF00496.22 ACT01651.1 - 2e-36 125.8 0.0 6.7e-36 124.0 0.0 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle SgrR_N PF12793.7 ACT01651.1 - 6.6e-32 110.1 0.0 6.3e-31 107.0 0.0 2.5 2 0 0 2 2 2 1 Sugar transport-related sRNA regulator N-term BAF PF02961.14 ACT01651.1 - 0.02 15.3 0.1 0.079 13.4 0.1 2.1 2 0 0 2 2 2 0 Barrier to autointegration factor NAGPA PF09992.9 ACT01652.1 - 1.4e-40 139.3 2.2 2.1e-40 138.7 2.2 1.3 1 0 0 1 1 1 1 Phosphodiester glycosidase DUF3994 PF13159.6 ACT01652.1 - 0.0099 16.4 0.5 0.022 15.3 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3994) DinB_2 PF12867.7 ACT01653.1 - 1.2e-10 42.0 0.2 1.4e-10 41.8 0.2 1.1 1 0 0 1 1 1 1 DinB superfamily DUF664 PF04978.12 ACT01653.1 - 5.9e-05 23.5 0.1 7.6e-05 23.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF664) MDMPI_N PF11716.8 ACT01653.1 - 0.0025 18.5 0.1 0.0034 18.1 0.1 1.2 1 0 0 1 1 1 1 Mycothiol maleylpyruvate isomerase N-terminal domain Bmp PF02608.14 ACT01654.1 - 1.6e-56 191.5 0.1 2.1e-56 191.1 0.1 1.1 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like Rieske PF00355.26 ACT01655.1 - 3.2e-20 71.9 0.1 5.5e-20 71.1 0.1 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PaO PF08417.12 ACT01655.1 - 0.16 12.1 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 Pheophorbide a oxygenase Response_reg PF00072.24 ACT01656.1 - 1e-26 93.3 0.2 1.4e-26 92.8 0.2 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT01656.1 - 5.6e-25 87.2 0.1 1.5e-24 85.8 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal HATPase_c PF02518.26 ACT01657.1 - 2.8e-27 95.4 0.1 7.4e-27 94.1 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT01657.1 - 1.4e-14 54.2 0.2 1.6e-13 50.8 0.1 2.3 2 0 0 2 2 2 1 HAMP domain HisKA PF00512.25 ACT01657.1 - 5.5e-07 29.5 0.9 6.6e-06 26.1 0.1 2.8 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ACT01657.1 - 0.00044 20.1 0.0 0.00081 19.2 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT01657.1 - 0.0021 18.0 0.0 0.0042 17.0 0.0 1.5 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 ACT01657.1 - 0.0064 16.5 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain TauE PF01925.19 ACT01657.1 - 0.29 10.7 2.3 0.52 9.9 2.3 1.3 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE DUF1541 PF07563.11 ACT01658.1 - 7.2e-55 182.7 15.2 6.2e-28 96.4 3.9 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1541) LPAM_1 PF08139.12 ACT01658.1 - 0.0062 17.0 2.8 0.013 15.9 2.8 1.5 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site DUF4926 PF16277.5 ACT01658.1 - 0.071 12.5 0.3 0.73 9.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4926) McyA_C PF12593.8 ACT01658.1 - 0.083 12.7 0.7 7.3 6.5 0.1 2.3 2 0 0 2 2 2 0 Microcystin synthetase C terminal DUF3234 PF11572.8 ACT01658.1 - 0.12 12.6 0.0 21 5.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3234) UDG PF03167.19 ACT01659.1 - 1.9e-06 27.9 0.2 1.6e-05 24.9 0.2 2.2 1 1 0 1 1 1 1 Uracil DNA glycosylase superfamily ROK PF00480.20 ACT01660.1 - 1.9e-11 44.0 0.1 1.5e-10 41.0 0.0 2.0 2 0 0 2 2 2 1 ROK family HTH_42 PF06224.12 ACT01660.1 - 0.024 14.2 0.0 0.036 13.6 0.0 1.1 1 0 0 1 1 1 0 Winged helix DNA-binding domain MFS_1 PF07690.16 ACT01661.1 - 1.4e-38 132.8 76.6 3.2e-30 105.3 47.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4405 PF14358.6 ACT01661.1 - 1.6 9.3 0.0 1.6 9.3 0.0 4.5 7 1 0 7 7 7 0 Domain of unknown function (DUF4405) HTH_18 PF12833.7 ACT01662.1 - 1.5e-21 76.4 0.2 3.3e-21 75.3 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01662.1 - 7.2e-14 51.5 0.0 2.1e-07 30.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT01662.1 - 3.7e-08 33.0 0.0 7.8e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACT01662.1 - 5.1e-07 29.7 0.2 1.1e-06 28.6 0.2 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain AraC_N PF06719.13 ACT01662.1 - 0.01 15.5 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 AraC-type transcriptional regulator N-terminus Cupin_6 PF12852.7 ACT01662.1 - 0.094 12.4 0.0 0.26 11.0 0.0 1.6 2 0 0 2 2 2 0 Cupin PhyH PF05721.13 ACT01663.1 - 2.6e-20 73.6 0.0 3.7e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Glyco_hydro_43 PF04616.14 ACT01664.1 - 6.2e-09 35.6 3.6 2.3e-06 27.2 0.9 3.6 1 1 0 2 2 2 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 ACT01664.1 - 3.2e-05 23.6 7.2 0.0038 16.8 2.7 4.1 2 1 0 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain Alpha-L-AF_C PF06964.12 ACT01665.1 - 4.1e-43 147.4 0.0 6.1e-43 146.9 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain HTH_18 PF12833.7 ACT01666.1 - 4.8e-21 74.8 3.3 4.9e-21 74.8 0.5 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01666.1 - 7e-16 57.9 1.2 2e-06 27.7 0.1 3.1 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT01666.1 - 1.1e-10 41.6 1.0 2.2e-09 37.3 0.2 2.3 1 1 1 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT01666.1 - 1.8e-08 33.9 0.2 3.7e-08 33.0 0.0 1.5 2 0 0 2 2 2 1 Cupin domain ARD PF03079.14 ACT01666.1 - 3e-06 27.5 0.2 3.5e-05 24.0 0.0 2.2 2 0 0 2 2 2 1 ARD/ARD' family Cupin_4 PF08007.12 ACT01666.1 - 7.8e-05 22.3 0.1 0.0001 21.9 0.1 1.3 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_1 PF00190.22 ACT01666.1 - 0.0024 17.5 0.0 0.0045 16.6 0.0 1.4 1 0 0 1 1 1 1 Cupin TPR_19 PF14559.6 ACT01666.1 - 0.052 14.1 0.5 0.17 12.4 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat CbiG_C PF01890.16 ACT01666.1 - 0.1 13.1 1.4 0.68 10.5 0.4 2.1 1 1 1 2 2 2 0 Cobalamin synthesis G C-terminus YdjM PF04307.14 ACT01667.1 - 1e-09 37.9 8.4 1e-07 31.5 8.4 2.2 1 1 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase VCBS PF13517.6 ACT01667.1 - 0.015 15.9 1.3 0.046 14.3 1.3 1.9 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ACT01667.1 - 0.018 15.2 2.8 0.044 13.9 2.8 1.6 1 0 0 1 1 1 0 FG-GAP repeat ECF-ribofla_trS PF07155.12 ACT01667.1 - 0.054 13.5 1.1 0.097 12.7 1.1 1.4 1 0 0 1 1 1 0 ECF-type riboflavin transporter, S component SWIM PF04434.17 ACT01668.1 - 2.1e-05 24.1 0.4 3.7e-05 23.3 0.4 1.4 1 0 0 1 1 1 1 SWIM zinc finger DUF935 PF06074.12 ACT01668.1 - 0.0048 15.7 0.0 0.0084 14.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF935) Macoilin PF09726.9 ACT01668.1 - 0.43 9.1 2.6 0.57 8.7 2.6 1.1 1 0 0 1 1 1 0 Macoilin family HEAT PF02985.22 ACT01669.1 - 0.071 13.4 0.6 0.93 9.9 0.0 3.1 3 0 0 3 3 3 0 HEAT repeat HEAT_PBS PF03130.16 ACT01669.1 - 0.17 12.7 7.2 7 7.6 0.4 4.9 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat AAA_5 PF07728.14 ACT01670.1 - 2.4e-35 121.5 0.0 4e-35 120.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ACT01670.1 - 3.5e-05 23.7 0.0 0.00035 20.4 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ACT01670.1 - 0.00024 20.8 0.0 0.0018 18.0 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain MCM PF00493.23 ACT01670.1 - 0.00086 18.5 0.1 0.0051 15.9 0.1 2.1 1 1 0 1 1 1 1 MCM P-loop domain AAA_16 PF13191.6 ACT01670.1 - 0.0066 16.8 0.2 0.011 16.1 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT01670.1 - 0.027 14.7 0.0 0.063 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ACT01670.1 - 0.093 12.2 0.1 0.8 9.2 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region VWA_CoxE PF05762.14 ACT01672.1 - 2.5e-48 164.4 0.0 3.7e-48 163.9 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_2 PF13519.6 ACT01672.1 - 0.019 15.6 0.0 0.057 14.1 0.0 1.8 1 0 0 1 1 1 0 von Willebrand factor type A domain Polysacc_synt PF01943.17 ACT01673.1 - 1e-37 130.0 18.0 1e-37 130.0 18.0 2.8 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.6 ACT01673.1 - 2.2e-17 63.5 22.9 2.2e-17 63.5 22.9 4.3 4 1 2 6 6 6 2 Polysaccharide biosynthesis C-terminal domain MatE PF01554.18 ACT01673.1 - 1.8e-12 47.2 22.7 4.5e-08 32.9 8.3 4.6 4 2 1 5 5 5 2 MatE Polysacc_synt_3 PF13440.6 ACT01673.1 - 1.6e-07 30.9 14.9 1.6e-07 30.9 14.9 4.2 1 1 3 4 4 4 3 Polysaccharide biosynthesis protein MurJ PF03023.14 ACT01673.1 - 6.5e-06 25.0 45.8 0.00026 19.7 33.5 2.9 1 1 1 2 2 2 1 Lipid II flippase MurJ DUF1700 PF08006.11 ACT01673.1 - 0.007 15.9 3.0 0.007 15.9 3.0 3.4 3 1 0 3 3 3 1 Protein of unknown function (DUF1700) TPR_5 PF12688.7 ACT01674.1 - 3.3e-15 56.4 1.0 2.1e-13 50.5 0.1 2.1 1 1 1 2 2 2 1 Tetratrico peptide repeat TPR_14 PF13428.6 ACT01674.1 - 6.1e-15 54.6 0.8 2.3e-06 27.9 0.0 4.1 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ACT01674.1 - 3.3e-14 51.8 0.1 7.5e-06 25.8 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ACT01674.1 - 1.3e-13 51.4 0.5 2.6e-06 28.0 0.1 2.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ACT01674.1 - 8.3e-13 47.4 0.1 5.1e-06 26.2 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ACT01674.1 - 7.4e-12 44.6 0.0 3.7e-05 23.4 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ACT01674.1 - 8.6e-12 44.9 1.1 5.5e-05 23.5 0.1 4.4 4 1 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ACT01674.1 - 1.2e-09 38.5 0.1 7.4e-06 26.4 0.1 2.4 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ACT01674.1 - 1.5e-09 38.0 0.0 1e-05 25.7 0.0 3.4 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ACT01674.1 - 1.5e-06 27.9 3.4 0.0044 16.9 0.1 3.7 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ACT01674.1 - 2.4e-05 24.4 2.3 3.5 8.2 0.0 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 ACT01674.1 - 9.2e-05 22.7 1.1 0.0055 17.0 0.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ACT01674.1 - 0.00048 20.3 0.5 0.036 14.3 0.0 2.1 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ACT01674.1 - 0.0012 18.6 4.3 0.3 11.0 0.1 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ACT01674.1 - 0.003 17.2 0.0 1.9 8.2 0.0 3.6 4 0 0 4 4 4 1 TPR repeat TPR_4 PF07721.14 ACT01674.1 - 0.03 14.9 1.1 1.2 10.0 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat NARP1 PF12569.8 ACT01674.1 - 0.064 12.1 0.3 0.16 10.8 0.2 1.6 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Aldo_ket_red PF00248.21 ACT01675.1 - 1.7e-78 263.8 0.1 2.1e-78 263.5 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Glyco_hydro_129 PF11308.8 ACT01676.1 - 6.9e-113 377.1 0.4 9.6e-113 376.6 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases related to GH101 family, GH129 Response_reg PF00072.24 ACT01677.1 - 8.1e-29 100.1 0.1 1.7e-28 99.0 0.0 1.5 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT01677.1 - 2.9e-25 88.2 0.0 5e-25 87.4 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HTH_11 PF08279.12 ACT01677.1 - 0.29 11.1 1.1 7.4 6.6 0.2 2.5 2 0 0 2 2 2 0 HTH domain HisKA PF00512.25 ACT01678.1 - 1.9e-13 50.2 0.1 7.5e-13 48.3 0.1 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT01678.1 - 1.4e-10 41.4 0.0 3.6e-10 40.1 0.0 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT01678.1 - 5.8e-08 33.2 0.0 1.1e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT01678.1 - 0.0013 18.6 0.0 0.0034 17.3 0.0 1.7 2 0 0 2 2 2 1 GHKL domain DUF3169 PF11368.8 ACT01678.1 - 0.015 14.8 0.2 0.18 11.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Baculo_PEP_C PF04513.12 ACT01678.1 - 0.65 10.0 6.2 0.52 10.3 0.5 2.6 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran PF00005.27 ACT01679.1 - 0.057 13.9 0.0 0.11 13.0 0.0 1.7 1 1 0 1 1 1 0 ABC transporter adh_short_C2 PF13561.6 ACT01680.1 - 1.7e-60 204.5 0.0 2.4e-60 204.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT01680.1 - 1.7e-46 158.2 0.2 1.9e-46 158.0 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT01680.1 - 4.3e-06 26.8 0.1 6.2e-06 26.2 0.1 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ACT01680.1 - 0.018 14.4 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Haem_degrading PF03928.14 ACT01681.1 - 2e-11 44.0 0.2 2.1e-11 43.9 0.2 1.0 1 0 0 1 1 1 1 Haem-degrading DeoRC PF00455.22 ACT01683.1 - 1.8e-48 164.5 0.4 2.7e-48 163.9 0.4 1.3 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 ACT01683.1 - 7.2e-18 64.1 0.3 1.7e-17 62.9 0.3 1.7 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACT01683.1 - 1.5e-06 28.0 0.1 4e-06 26.7 0.1 1.7 1 0 0 1 1 1 1 HTH domain GntR PF00392.21 ACT01683.1 - 0.0015 18.2 0.0 0.0033 17.0 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HemN_C PF06969.16 ACT01683.1 - 0.0054 16.8 0.1 0.013 15.6 0.1 1.7 1 0 0 1 1 1 1 HemN C-terminal domain IF-2B PF01008.17 ACT01683.1 - 0.012 14.9 0.4 2.8 7.1 0.1 2.5 3 0 0 3 3 3 0 Initiation factor 2 subunit family DUF2470 PF10615.9 ACT01683.1 - 0.014 16.0 0.5 0.041 14.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2470) Mga PF05043.13 ACT01683.1 - 0.018 15.6 0.0 0.057 14.0 0.0 1.8 1 0 0 1 1 1 0 Mga helix-turn-helix domain HTH_24 PF13412.6 ACT01683.1 - 0.04 13.5 0.1 0.094 12.3 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR PF01047.22 ACT01683.1 - 0.041 13.8 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 MarR family FeoC PF09012.10 ACT01683.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_29 PF13551.6 ACT01683.1 - 0.062 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix Tn7_Tnp_TnsA_C PF08721.11 ACT01683.1 - 0.064 13.9 0.2 0.21 12.2 0.1 1.9 2 0 0 2 2 2 0 TnsA endonuclease C terminal SCAB-ABD PF16711.5 ACT01683.1 - 0.071 13.0 0.1 0.18 11.8 0.1 1.7 1 0 0 1 1 1 0 Actin-binding domain of plant-specific actin-binding protein HTH_IclR PF09339.10 ACT01683.1 - 0.092 12.6 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain PaaX PF07848.12 ACT01683.1 - 0.11 12.7 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 PaaX-like protein HTH_36 PF13730.6 ACT01683.1 - 0.12 12.4 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain Hydrolase_3 PF08282.12 ACT01684.1 - 1.1e-49 169.5 0.0 1.2e-49 169.3 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ACT01684.1 - 5.1e-16 59.0 0.0 5.4e-10 39.2 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 ACT01684.1 - 2.5e-09 37.8 0.0 4.1e-08 33.8 0.0 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 ACT01684.1 - 0.00032 19.9 0.1 0.028 13.6 0.0 2.4 2 1 0 2 2 2 2 Trehalose-phosphatase HAD_2 PF13419.6 ACT01684.1 - 0.0009 19.4 0.0 1.5 8.9 0.0 2.7 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT01684.1 - 0.0061 17.0 0.0 3.6 7.9 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase MFS_1 PF07690.16 ACT01685.1 - 2.3e-34 118.9 61.2 2.4e-17 62.9 32.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ACT01685.1 - 1.8e-05 24.2 33.5 3.2e-05 23.4 33.3 1.5 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 ACT01685.1 - 0.0022 16.3 4.1 0.0022 16.3 4.1 2.3 2 1 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 ACT01685.1 - 0.29 9.7 42.8 0.011 14.3 14.7 3.1 1 1 2 3 3 3 0 MFS/sugar transport protein Ac76 PF05814.11 ACT01685.1 - 0.41 10.7 3.4 1.1 9.3 0.1 3.1 3 0 0 3 3 3 0 Orf76 (Ac76) DUF2568 PF10823.8 ACT01686.1 - 4e-24 84.7 12.4 5.9e-24 84.2 12.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2568) DUF2070 PF09843.9 ACT01686.1 - 7.2 4.8 14.3 8.3 4.6 14.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) CLP_protease PF00574.23 ACT01687.1 - 4.1e-84 281.0 0.1 4.7e-84 280.8 0.1 1.0 1 0 0 1 1 1 1 Clp protease Sigma70_r2 PF04542.14 ACT01688.1 - 1.4e-15 56.8 0.6 2.9e-15 55.8 0.6 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT01688.1 - 1.9e-13 49.8 0.1 3.9e-13 48.8 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT01688.1 - 4.3e-06 26.1 0.0 1e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACT01688.1 - 5.7e-05 23.1 0.5 8e-05 22.6 0.5 1.3 1 0 0 1 1 1 1 ECF sigma factor GerA PF03323.13 ACT01689.1 - 8.5e-174 578.4 0.9 1.1e-173 578.1 0.9 1.1 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein PAAR_motif PF05488.13 ACT01689.1 - 0.038 14.2 0.0 0.15 12.3 0.0 1.9 2 0 0 2 2 2 0 PAAR motif Spore_GerAC PF05504.11 ACT01690.1 - 5.2e-29 101.6 3.2 7.4e-29 101.1 3.2 1.2 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal DUF2407 PF10302.9 ACT01690.1 - 0.051 14.1 0.6 0.31 11.6 0.3 2.1 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Spore_permease PF03845.13 ACT01691.1 - 1.6e-52 178.4 47.2 1.6e-52 178.4 47.2 1.5 2 0 0 2 2 2 1 Spore germination protein Flavodoxin_2 PF02525.17 ACT01692.1 - 1.7e-43 148.7 0.0 2e-43 148.4 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ACT01692.1 - 8.3e-06 25.6 0.0 1.5e-05 24.8 0.0 1.4 1 1 0 1 1 1 1 NADPH-dependent FMN reductase HxlR PF01638.17 ACT01693.1 - 1.4e-31 108.1 0.0 1.9e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix MarR PF01047.22 ACT01693.1 - 0.00031 20.6 0.0 0.00058 19.7 0.0 1.4 1 0 0 1 1 1 1 MarR family PadR PF03551.14 ACT01693.1 - 0.0047 16.9 0.1 0.008 16.1 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.6 ACT01693.1 - 0.0098 16.0 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF4010 PF13194.6 ACT01694.1 - 0.037 13.7 0.1 0.067 12.9 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4010) Herpes_LMP1 PF05297.11 ACT01694.1 - 0.14 11.3 2.1 0.18 11.0 2.1 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Maf_N PF08383.11 ACT01694.1 - 0.22 11.3 0.7 0.5 10.2 0.1 1.8 2 0 0 2 2 2 0 Maf N-terminal region VEGFR-2_TMD PF17988.1 ACT01694.1 - 2.2 7.8 11.8 1.4 8.4 1.0 2.3 2 0 0 2 2 2 0 VEGFR-2 Transmembrane domain FHA PF00498.26 ACT01695.1 - 5.6e-14 52.2 0.0 1.2e-13 51.2 0.0 1.6 1 0 0 1 1 1 1 FHA domain Trans_reg_C PF00486.28 ACT01695.1 - 2.3e-11 43.6 0.1 3.9e-11 42.9 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Yop-YscD_cpl PF16697.5 ACT01695.1 - 1.1e-07 32.1 0.0 2.3e-07 31.0 0.0 1.5 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain EPSP_synthase PF00275.20 ACT01696.1 - 2.5e-72 243.8 0.0 2.9e-72 243.6 0.0 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) ADH_zinc_N PF00107.26 ACT01696.1 - 0.0041 17.1 0.1 0.012 15.6 0.1 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Zn_dep_PLPC PF00882.18 ACT01697.1 - 0.0015 18.6 0.2 0.0022 18.0 0.2 1.3 1 0 0 1 1 1 1 Zinc dependent phospholipase C PX PF00787.24 ACT01697.1 - 0.085 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 PX domain Spore_GerAC PF05504.11 ACT01698.1 - 3.3e-18 66.4 0.6 3.3e-18 66.4 0.6 1.5 2 0 0 2 2 2 1 Spore germination B3/ GerAC like, C-terminal Spore_permease PF03845.13 ACT01699.1 - 2.7e-24 85.6 39.2 3.8e-24 85.1 39.2 1.1 1 0 0 1 1 1 1 Spore germination protein GerA PF03323.13 ACT01700.1 - 1.3e-95 320.7 4.6 1.5e-95 320.4 4.6 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein eIF-5_eIF-2B PF01873.17 ACT01700.1 - 0.11 12.4 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain found in IF2B/IF5 TetR_N PF00440.23 ACT01701.1 - 1.6e-14 53.4 0.1 6.3e-14 51.5 0.1 2.0 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family TetR_C_10 PF16295.5 ACT01701.1 - 2e-07 31.4 0.1 2.6e-07 31.0 0.1 1.2 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_4 PF08359.11 ACT01701.1 - 0.028 14.6 0.0 0.05 13.8 0.0 1.4 1 0 0 1 1 1 0 YsiA-like protein, C-terminal region adh_short PF00106.25 ACT01702.1 - 6.7e-48 162.7 0.0 8.7e-48 162.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT01702.1 - 5.4e-39 134.1 0.0 8.7e-39 133.4 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT01702.1 - 3.2e-15 56.5 0.0 4.7e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ACT01702.1 - 2.6e-07 30.7 0.1 6e-07 29.5 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 ACT01702.1 - 0.00052 19.5 0.0 0.00077 19.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 ACT01702.1 - 0.00092 18.7 0.0 0.0013 18.2 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.17 ACT01702.1 - 0.0041 16.3 0.1 0.0077 15.4 0.1 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain F420_oxidored PF03807.17 ACT01702.1 - 0.022 15.3 0.0 0.052 14.1 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ABM PF03992.16 ACT01703.1 - 3.4e-13 49.5 0.0 4.6e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase MFS_1 PF07690.16 ACT01704.1 - 3.1e-48 164.5 59.5 3.1e-48 164.5 59.5 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01704.1 - 1e-18 67.5 38.4 1.8e-16 60.1 15.3 3.2 2 1 1 4 4 4 2 Sugar (and other) transporter TRI12 PF06609.13 ACT01704.1 - 4.6e-09 35.2 28.1 4e-08 32.1 28.0 2.0 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 ACT01704.1 - 0.0003 19.5 53.4 0.00079 18.1 13.0 4.2 2 1 2 4 4 4 3 MFS/sugar transport protein ATP1G1_PLM_MAT8 PF02038.16 ACT01704.1 - 4 6.9 8.9 5.9 6.4 0.1 3.7 3 0 0 3 3 3 0 ATP1G1/PLM/MAT8 family OATP PF03137.20 ACT01704.1 - 5.4 5.2 24.1 0.072 11.4 8.7 2.9 2 2 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Phage_integrase PF00589.22 ACT01706.1 - 1.1e-35 122.9 0.0 2e-35 122.1 0.0 1.4 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_4 PF13495.6 ACT01706.1 - 3.2e-12 46.8 0.1 6e-12 45.9 0.1 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 ACT01706.1 - 1.1e-05 25.6 0.3 2.6e-05 24.4 0.3 1.6 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_integr_3 PF16795.5 ACT01706.1 - 0.0014 18.6 0.1 0.18 11.7 0.0 2.5 2 0 0 2 2 2 2 Archaeal phage integrase Isochorismatase PF00857.20 ACT01707.1 - 1.6e-44 152.2 0.3 1.8e-44 152.0 0.3 1.0 1 0 0 1 1 1 1 Isochorismatase family IMPa_N_2 PF18650.1 ACT01707.1 - 0.064 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Immunomodulating metalloprotease N-terminal domain BNR_2 PF13088.6 ACT01708.1 - 2.2e-09 37.0 1.1 3.8e-06 26.4 0.1 3.5 2 2 1 3 3 3 3 BNR repeat-like domain BNR PF02012.20 ACT01708.1 - 4.1e-06 26.0 17.4 0.42 10.8 0.2 5.9 5 0 0 5 5 5 4 BNR/Asp-box repeat CAP_C PF08603.11 ACT01708.1 - 0.056 13.1 0.5 2 8.0 0.0 2.6 3 0 0 3 3 3 0 Adenylate cyclase associated (CAP) C terminal PUA_2 PF14306.6 ACT01708.1 - 0.1 12.2 0.0 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 PUA-like domain ABC_tran PF00005.27 ACT01710.1 - 1.4e-25 90.4 0.0 2e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01710.1 - 1.3e-09 38.3 0.0 4.6e-06 26.7 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT01710.1 - 3e-05 23.6 0.0 0.0058 16.1 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ACT01710.1 - 0.00011 22.4 0.3 0.0031 17.7 0.3 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit NTPase_1 PF03266.15 ACT01710.1 - 0.0046 16.9 0.1 0.37 10.7 0.0 2.2 2 0 0 2 2 2 1 NTPase AAA_16 PF13191.6 ACT01710.1 - 0.0051 17.2 0.0 0.008 16.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT01710.1 - 0.0085 15.8 0.1 0.025 14.3 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ACT01710.1 - 0.0092 16.3 0.1 0.13 12.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ACT01710.1 - 0.052 13.1 0.0 1.5 8.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain ABC-3 PF00950.17 ACT01711.1 - 9.9e-66 221.9 30.5 1.2e-65 221.6 30.5 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 ACT01711.1 - 8.2e-10 38.2 26.9 8.2e-10 38.2 26.9 2.0 1 1 1 2 2 2 1 FecCD transport family Phage_holin_3_1 PF05106.12 ACT01711.1 - 0.028 14.9 1.5 0.028 14.9 1.5 3.0 2 1 1 3 3 3 0 Phage holin family (Lysis protein S) ZnuA PF01297.17 ACT01712.1 - 3.9e-81 272.2 4.2 4.5e-81 272.0 4.2 1.0 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic HpaB_N PF11794.8 ACT01712.1 - 0.03 14.0 0.1 0.062 12.9 0.1 1.5 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal BssS PF13991.6 ACT01712.1 - 0.1 12.7 0.1 0.22 11.6 0.1 1.6 1 0 0 1 1 1 0 BssS protein family cobW PF02492.19 ACT01713.1 - 6.3e-56 188.7 0.3 8.2e-56 188.4 0.3 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ACT01713.1 - 1.2e-24 86.1 0.0 2.9e-24 84.8 0.0 1.7 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 ACT01713.1 - 0.003 17.5 0.5 0.28 11.1 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ACT01713.1 - 0.0097 15.5 0.2 0.27 10.8 0.0 2.4 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 ACT01713.1 - 0.028 13.4 0.7 0.9 8.5 0.4 2.8 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 ACT01713.1 - 0.086 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 ACT01713.1 - 0.097 12.7 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MobB PF03205.14 ACT01713.1 - 0.11 12.4 0.3 0.38 10.7 0.1 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 ACT01713.1 - 0.13 12.6 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 ACT01713.1 - 0.17 10.9 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 ACT01713.1 - 0.19 11.0 0.0 0.38 10.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 ACT01713.1 - 0.2 11.4 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Acetyltransf_10 PF13673.7 ACT01715.1 - 2.1e-15 56.8 0.8 2.7e-15 56.4 0.8 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT01715.1 - 2.2e-15 56.9 0.1 2.7e-15 56.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT01715.1 - 5.7e-08 33.1 0.2 9.5e-08 32.4 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACT01715.1 - 6.4e-08 33.4 0.1 8.3e-08 33.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT01715.1 - 8.8e-07 28.8 0.2 2.3e-06 27.5 0.0 1.8 2 1 1 3 3 3 1 FR47-like protein Acetyltransf_4 PF13420.7 ACT01715.1 - 1.7e-06 28.2 1.2 2.2e-06 27.9 1.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ACT01715.1 - 0.00071 19.3 0.1 0.0096 15.6 0.1 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACT01715.1 - 0.0053 16.9 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Nudix_hydro PF18290.1 ACT01715.1 - 0.011 15.7 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 Nudix hydrolase domain Acetyltransf_9 PF13527.7 ACT01715.1 - 0.038 14.1 0.1 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Polyketide_cyc2 PF10604.9 ACT01716.1 - 3.2e-05 24.2 0.0 3.6e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 ACT01716.1 - 0.001 19.3 0.0 0.0012 19.1 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Arabinose_bd PF12625.7 ACT01717.1 - 7.5e-26 91.4 0.2 1.2e-25 90.7 0.0 1.4 2 0 0 2 2 2 1 Arabinose-binding domain of AraC transcription regulator, N-term HTH_18 PF12833.7 ACT01717.1 - 2.4e-19 69.4 0.2 6.5e-19 68.0 0.1 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01717.1 - 3.1e-08 33.5 0.0 2.1e-05 24.5 0.0 2.9 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family SurA_N PF09312.11 ACT01717.1 - 0.032 14.3 0.1 0.26 11.4 0.1 2.2 2 0 0 2 2 2 0 SurA N-terminal domain HTH_8 PF02954.19 ACT01717.1 - 0.048 13.4 0.1 0.19 11.5 0.1 2.0 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_Tnp_ISL3 PF13542.6 ACT01717.1 - 0.057 12.8 0.2 0.43 10.0 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 ACT01717.1 - 0.069 13.0 1.9 6 6.8 0.0 3.6 4 0 0 4 4 4 0 Homeodomain-like domain CoA_transf_3 PF02515.17 ACT01717.1 - 0.16 11.0 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 CoA-transferase family III adh_short PF00106.25 ACT01718.1 - 3.9e-42 143.9 0.0 4.9e-42 143.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT01718.1 - 4.4e-38 131.2 0.0 1.3e-37 129.6 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ACT01718.1 - 1.1e-10 41.4 0.1 2.2e-10 40.4 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ACT01718.1 - 2.9e-10 40.3 0.1 3.8e-10 40.0 0.1 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ACT01718.1 - 0.00019 20.6 0.1 0.00024 20.3 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ACT01718.1 - 0.0015 17.7 0.3 0.0024 17.0 0.3 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 ACT01718.1 - 0.0081 15.6 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_2 PF03446.15 ACT01718.1 - 0.013 15.6 0.3 0.054 13.7 0.3 1.9 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase THF_DHG_CYH_C PF02882.19 ACT01718.1 - 0.015 14.6 0.5 0.2 11.0 0.1 2.2 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 ACT01718.1 - 0.02 14.8 0.1 0.053 13.4 0.2 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ACT01718.1 - 0.14 12.8 0.1 0.27 11.8 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GerA PF03323.13 ACT01720.1 - 6.7e-180 598.5 8.3 8.2e-180 598.2 8.3 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Succ_CoA_lig PF13607.6 ACT01720.1 - 0.019 14.8 0.0 2.5 7.9 0.0 2.6 2 0 0 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain Spore_GerAC PF05504.11 ACT01721.1 - 1.9e-38 132.3 0.1 2.8e-38 131.7 0.1 1.3 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal DUF5360 PF17314.2 ACT01722.1 - 0.032 14.3 1.2 0.26 11.4 1.2 2.0 1 1 0 1 1 1 0 Family of unknown function (DUF5360) Spore_permease PF03845.13 ACT01723.1 - 1.4e-62 211.4 30.7 2e-62 210.9 30.7 1.2 1 0 0 1 1 1 1 Spore germination protein DUF3817 PF12823.7 ACT01723.1 - 0.11 13.3 0.8 0.11 13.3 0.8 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3817) Peripla_BP_2 PF01497.18 ACT01724.1 - 1.3e-22 80.5 0.0 1.8e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein DUF3558 PF12079.8 ACT01724.1 - 0.015 15.3 2.2 0.022 14.7 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) ZapA PF05164.13 ACT01724.1 - 0.17 12.3 0.3 0.37 11.2 0.3 1.5 1 0 0 1 1 1 0 Cell division protein ZapA HTH_18 PF12833.7 ACT01725.1 - 6.6e-18 64.8 1.0 1.4e-17 63.7 1.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01725.1 - 8e-17 60.9 0.2 1.8e-07 31.1 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Peripla_BP_2 PF01497.18 ACT01725.1 - 7.4e-11 42.1 0.0 1.3e-10 41.2 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding protein DUF4062 PF13271.6 ACT01726.1 - 8.8e-14 51.7 0.0 2.1e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) HATPase_c PF02518.26 ACT01728.1 - 1.6e-28 99.5 0.0 3.5e-28 98.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ACT01728.1 - 3.3e-23 82.0 0.1 6.1e-23 81.1 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain PAS PF00989.25 ACT01728.1 - 4.7e-21 74.9 0.0 5.3e-10 39.3 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 ACT01728.1 - 1.3e-20 73.5 0.0 4.2e-11 43.0 0.0 2.9 3 0 0 3 3 3 2 PAS domain HisKA PF00512.25 ACT01728.1 - 2.8e-20 72.1 0.0 7e-20 70.8 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 ACT01728.1 - 4.1e-12 46.3 0.0 4.8e-07 30.0 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.12 ACT01728.1 - 1.6e-10 41.1 0.0 4.6e-09 36.4 0.0 2.6 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 ACT01728.1 - 1.2e-05 25.2 0.0 4.1e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 PAS domain Glyco_hydro_2_N PF02837.18 ACT01729.1 - 2e-08 34.3 0.0 4.7e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 ACT01729.1 - 1.2e-07 32.3 0.0 4.1e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_C PF02836.17 ACT01729.1 - 1.2e-07 31.1 0.0 1.9e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Big_7 PF17957.1 ACT01729.1 - 0.042 14.6 5.0 0.12 13.1 0.0 3.5 4 0 0 4 4 4 0 Bacterial Ig domain CE2_N PF17996.1 ACT01729.1 - 0.091 12.7 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal PrsW-protease PF13367.6 ACT01731.1 - 3.2e-15 56.1 10.3 2.3e-14 53.3 10.3 2.2 1 1 0 1 1 1 1 PrsW family intramembrane metalloprotease DUF2627 PF11118.8 ACT01731.1 - 0.0038 17.8 0.3 3.2 8.4 0.0 3.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2627) T2SSM PF04612.12 ACT01731.1 - 0.016 15.3 0.1 0.046 13.8 0.1 1.8 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M DUF2554 PF10829.8 ACT01731.1 - 0.14 12.6 0.0 0.37 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2554) DUF2207 PF09972.9 ACT01731.1 - 2.2 6.9 5.5 9.5 4.8 3.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) ComP_DUS PF16732.5 ACT01733.1 - 0.042 14.7 2.6 1 10.3 0.5 2.4 1 1 0 2 2 2 0 Type IV minor pilin ComP, DNA uptake sequence receptor LUC7 PF03194.15 ACT01733.1 - 0.054 13.2 4.3 0.11 12.2 4.3 1.6 1 1 0 1 1 1 0 LUC7 N_terminus Fib_alpha PF08702.10 ACT01733.1 - 0.064 13.4 6.0 0.067 13.4 4.0 1.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 ACT01733.1 - 0.27 11.7 2.1 24 5.5 0.5 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ZapB PF06005.12 ACT01733.1 - 0.33 11.4 0.3 0.33 11.4 0.3 2.9 2 2 1 3 3 3 0 Cell division protein ZapB Uso1_p115_C PF04871.13 ACT01733.1 - 0.65 10.4 7.7 4.9 7.5 4.3 2.6 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Acetyltransf_1 PF00583.25 ACT01734.1 - 6e-11 42.6 0.0 7.2e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 ACT01734.1 - 3.4e-09 37.5 0.0 4e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT01734.1 - 4.9e-09 36.5 0.0 6.9e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT01734.1 - 1.2e-05 25.2 0.0 1.9e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ACT01734.1 - 6.7e-05 22.8 0.0 0.00018 21.5 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ACT01734.1 - 0.048 13.3 0.0 0.064 12.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain APH PF01636.23 ACT01735.1 - 1.3e-14 54.7 0.0 1.9e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ACT01735.1 - 1.1e-09 38.2 0.0 2.2e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 ACT01735.1 - 0.032 13.5 0.1 0.2 10.8 0.1 2.0 1 1 0 1 1 1 0 Fructosamine kinase EcKinase PF02958.20 ACT01735.1 - 0.098 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase RIO1 PF01163.22 ACT01735.1 - 0.13 11.8 0.0 0.29 10.7 0.0 1.5 2 0 0 2 2 2 0 RIO1 family Amidase PF01425.21 ACT01736.1 - 3.6e-80 270.1 0.1 2.4e-79 267.4 0.0 1.8 2 0 0 2 2 2 1 Amidase NAD_synthase PF02540.17 ACT01736.1 - 0.053 12.6 0.1 0.091 11.9 0.1 1.3 1 0 0 1 1 1 0 NAD synthase MFS_1 PF07690.16 ACT01737.1 - 1.3e-66 225.0 68.4 3.4e-54 184.1 45.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01737.1 - 5.9e-10 38.6 32.9 0.00014 20.9 12.4 3.2 2 2 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 ACT01737.1 - 0.28 9.5 24.4 0.0027 16.2 13.1 2.1 1 1 1 2 2 2 0 Fungal trichothecene efflux pump (TRI12) LysR_substrate PF03466.20 ACT01738.1 - 5.5e-39 133.7 0.0 7.4e-39 133.3 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01738.1 - 3.3e-19 68.6 0.9 7.5e-19 67.4 0.9 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 ACT01738.1 - 0.00041 19.5 0.0 0.015 14.4 0.0 2.4 1 1 0 1 1 1 1 PBP superfamily domain MarR_2 PF12802.7 ACT01738.1 - 0.0023 17.8 0.3 0.008 16.1 0.2 2.0 2 0 0 2 2 2 1 MarR family HTH_28 PF13518.6 ACT01738.1 - 0.0036 17.4 0.0 0.0089 16.1 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain PBP_like_2 PF12849.7 ACT01738.1 - 0.0043 16.8 0.0 0.015 15.0 0.0 1.9 1 1 0 1 1 1 1 PBP superfamily domain SBP_bac_3 PF00497.20 ACT01738.1 - 0.023 14.2 0.0 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 HTH_23 PF13384.6 ACT01738.1 - 0.033 14.0 0.0 0.16 11.8 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain Fe_dep_repress PF01325.19 ACT01738.1 - 0.07 13.3 0.1 0.33 11.2 0.0 2.0 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_30 PF13556.6 ACT01738.1 - 0.074 12.9 0.3 0.14 11.9 0.3 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain AMMECR1 PF01871.17 ACT01738.1 - 0.15 11.7 0.0 0.3 10.7 0.0 1.5 1 1 0 1 1 1 0 AMMECR1 HTH_20 PF12840.7 ACT01738.1 - 0.16 12.0 1.7 0.73 9.9 0.3 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain DinB PF05163.12 ACT01739.1 - 1.8e-28 99.6 0.1 2.1e-28 99.4 0.1 1.0 1 0 0 1 1 1 1 DinB family DinB_2 PF12867.7 ACT01739.1 - 1.5e-12 48.1 0.2 1.9e-12 47.8 0.2 1.1 1 0 0 1 1 1 1 DinB superfamily DUF664 PF04978.12 ACT01739.1 - 8.4e-06 26.3 0.1 2.1e-05 25.0 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF664) RVT_3 PF13456.6 ACT01740.1 - 2.8e-14 53.0 0.0 3.2e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase-like RNase_H PF00075.24 ACT01740.1 - 4.3e-12 46.4 0.0 1.5e-11 44.6 0.0 1.7 1 1 0 1 1 1 1 RNase H HTH_18 PF12833.7 ACT01741.1 - 1.2e-18 67.1 0.0 1.9e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01741.1 - 1.8e-14 53.4 0.1 2.2e-10 40.4 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT01741.1 - 1.9e-12 47.2 0.0 3.3e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT01741.1 - 8.6e-07 28.6 0.0 2.1e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 ACT01741.1 - 0.00077 19.1 0.0 0.0018 17.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Ectoine_synth PF06339.12 ACT01741.1 - 0.15 12.3 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 Ectoine synthase Cupin_6 PF12852.7 ACT01741.1 - 0.16 11.6 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Cupin Alpha-L-AF_C PF06964.12 ACT01742.1 - 7.8e-14 52.1 0.0 1.2e-12 48.3 0.0 2.2 1 1 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Glyco_hydro_79n PF03662.14 ACT01742.1 - 0.00023 20.2 0.0 0.00051 19.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 79, N-terminal domain CBM_4_9 PF02018.17 ACT01742.1 - 0.0055 17.0 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate binding domain Glyco_hydro_44 PF12891.7 ACT01742.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycoside hydrolase family 44 APH PF01636.23 ACT01743.1 - 3.1e-13 50.2 2.3 4.3e-13 49.8 1.2 1.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ACT01743.1 - 0.0017 18.0 0.0 0.0035 17.0 0.0 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 ACT01743.1 - 0.023 14.3 0.0 0.065 12.8 0.0 1.7 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 ACT01743.1 - 0.031 13.7 0.1 0.21 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein kinase domain Response_reg PF00072.24 ACT01744.1 - 1.7e-30 105.5 0.2 5.6e-30 103.8 0.1 1.7 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT01744.1 - 1.2e-24 86.2 0.3 5.2e-24 84.1 0.0 2.0 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal DUF3727 PF12527.8 ACT01744.1 - 0.039 14.2 0.0 5.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3727) HATPase_c PF02518.26 ACT01745.1 - 9e-19 68.0 0.0 2.1e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT01745.1 - 1.9e-17 63.0 1.1 5.1e-17 61.7 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT01745.1 - 5.5e-10 39.5 0.1 1.7e-09 37.9 0.1 1.9 1 0 0 1 1 1 1 HAMP domain HATPase_c_5 PF14501.6 ACT01745.1 - 0.0033 17.3 0.0 0.01 15.7 0.0 1.9 1 0 0 1 1 1 1 GHKL domain FGGY_N PF00370.21 ACT01745.1 - 0.051 13.1 0.0 0.73 9.3 0.0 2.3 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain HalX PF08663.10 ACT01745.1 - 0.18 12.1 2.9 0.54 10.6 2.9 1.9 1 0 0 1 1 1 0 HalX domain DASH_Dad1 PF08649.10 ACT01745.1 - 0.39 10.9 2.9 5.2 7.3 0.2 3.7 4 0 0 4 4 4 0 DASH complex subunit Dad1 GRP PF07172.11 ACT01746.1 - 0.059 14.1 0.5 0.62 10.8 0.0 2.2 2 0 0 2 2 2 0 Glycine rich protein family RuBisCo_chap_C PF18087.1 ACT01746.1 - 0.15 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 Rubisco Assembly chaperone C-terminal domain ODV-E18 PF10717.9 ACT01746.1 - 0.27 11.1 5.7 0.21 11.5 3.1 2.2 1 1 1 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 HTH_20 PF12840.7 ACT01747.1 - 4.6e-13 49.0 0.2 6.7e-13 48.5 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 ACT01747.1 - 2.1e-10 40.3 0.0 3.4e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 ACT01747.1 - 7e-05 22.3 0.0 0.00013 21.5 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 ACT01747.1 - 0.0003 20.7 0.2 0.0003 20.7 0.2 1.5 2 0 0 2 2 2 1 HTH domain MarR_2 PF12802.7 ACT01747.1 - 0.004 17.0 0.2 0.0057 16.5 0.2 1.2 1 0 0 1 1 1 1 MarR family MarR PF01047.22 ACT01747.1 - 0.0045 16.9 0.1 0.0067 16.3 0.1 1.2 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.20 ACT01747.1 - 0.011 16.1 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator GntR PF00392.21 ACT01747.1 - 0.013 15.2 0.1 0.021 14.5 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_27 PF13463.6 ACT01747.1 - 0.015 15.8 0.1 0.021 15.3 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_IclR PF09339.10 ACT01747.1 - 0.019 14.8 0.1 0.035 13.9 0.1 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain RP-C PF03428.13 ACT01747.1 - 0.034 13.8 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Replication protein C N-terminal domain FUR PF01475.19 ACT01747.1 - 0.054 13.6 0.0 0.082 13.1 0.0 1.4 1 1 0 1 1 1 0 Ferric uptake regulator family PaaX PF07848.12 ACT01747.1 - 0.068 13.4 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 PaaX-like protein TrmB PF01978.19 ACT01747.1 - 0.099 12.5 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.6 ACT01747.1 - 0.13 12.5 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain AHSA1 PF08327.11 ACT01748.1 - 8.4e-17 61.6 1.0 9.5e-17 61.4 1.0 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ACT01748.1 - 2.5e-07 31.1 1.3 3.8e-07 30.5 1.3 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport ABC_tran PF00005.27 ACT01749.1 - 2.2e-22 80.1 0.2 2.4e-12 47.6 0.0 3.7 3 1 0 3 3 3 3 ABC transporter SMC_N PF02463.19 ACT01749.1 - 7.6e-11 41.9 2.6 0.068 12.6 0.0 4.1 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT01749.1 - 8e-10 39.0 3.2 0.0058 16.5 0.0 4.1 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT01749.1 - 1.2e-07 31.3 0.1 0.0069 16.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT01749.1 - 3.3e-07 30.8 0.0 0.02 15.2 0.0 3.1 3 1 0 3 3 3 2 AAA ATPase domain UvrA_DNA-bind PF17755.1 ACT01749.1 - 6.4e-07 29.7 0.1 1.7e-06 28.3 0.1 1.8 1 0 0 1 1 1 1 UvrA DNA-binding domain RsgA_GTPase PF03193.16 ACT01749.1 - 2.8e-06 27.3 0.2 0.018 14.9 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase Viral_helicase1 PF01443.18 ACT01749.1 - 9.1e-06 25.6 0.0 0.0025 17.6 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DnaJ_CXXCXGXG PF00684.19 ACT01749.1 - 9e-05 22.8 6.4 0.027 14.8 0.3 3.5 3 0 0 3 3 3 1 DnaJ central domain AAA_15 PF13175.6 ACT01749.1 - 0.00019 21.3 7.5 2.4 7.8 0.0 4.3 4 1 0 5 5 4 2 AAA ATPase domain AAA_7 PF12775.7 ACT01749.1 - 0.00058 19.4 0.2 0.92 9.0 0.1 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_22 PF13401.6 ACT01749.1 - 0.0014 18.9 0.2 0.5 10.6 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_23 PF13476.6 ACT01749.1 - 0.0015 19.1 4.1 1.1 9.7 0.2 3.1 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 ACT01749.1 - 0.0048 17.1 0.0 1.7 8.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 ACT01749.1 - 0.0063 16.1 0.4 0.84 9.2 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 ACT01749.1 - 0.0069 16.0 0.0 2.1 7.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 ACT01749.1 - 0.012 14.9 0.3 0.74 9.0 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 ACT01749.1 - 0.012 15.3 0.3 1.8 8.2 0.0 2.9 4 0 0 4 4 3 0 AAA domain RNA12 PF10443.9 ACT01749.1 - 0.024 13.4 0.0 0.36 9.5 0.0 2.2 2 0 0 2 2 2 0 RNA12 protein AAA_14 PF13173.6 ACT01749.1 - 0.026 14.5 0.0 11 6.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 ACT01749.1 - 0.055 14.0 0.4 18 5.9 0.0 3.5 4 0 0 4 4 4 0 AAA domain DUF1924 PF09086.11 ACT01749.1 - 0.08 13.3 0.7 0.94 9.9 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1924) T2SSE PF00437.20 ACT01749.1 - 0.13 11.3 0.2 6.5 5.7 0.1 2.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_24 PF13479.6 ACT01749.1 - 0.28 10.9 1.0 3.8 7.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain Anti-TRAP PF15777.5 ACT01749.1 - 2.1 8.4 7.0 13 5.8 0.3 3.4 3 0 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein LysR_substrate PF03466.20 ACT01750.1 - 1e-37 129.5 0.0 1.3e-37 129.2 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01750.1 - 5.5e-24 83.9 0.0 1.2e-23 82.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_24 PF13412.6 ACT01750.1 - 0.0045 16.5 0.0 0.029 13.9 0.0 2.5 4 0 0 4 4 4 1 Winged helix-turn-helix DNA-binding HTH_30 PF13556.6 ACT01750.1 - 0.005 16.6 0.0 0.0097 15.7 0.0 1.4 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_20 PF12840.7 ACT01750.1 - 0.0055 16.7 0.0 0.018 15.1 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_8 PF02954.19 ACT01750.1 - 0.065 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family MarR PF01047.22 ACT01750.1 - 0.071 13.1 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_5 PF01022.20 ACT01750.1 - 0.11 12.4 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Spore_permease PF03845.13 ACT01751.1 - 5.2e-42 143.8 34.0 7.7e-42 143.2 34.0 1.2 1 0 0 1 1 1 1 Spore germination protein Spore_GerAC PF05504.11 ACT01752.1 - 2.7e-28 99.3 0.4 2.7e-28 99.3 0.4 1.6 2 0 0 2 2 2 1 Spore germination B3/ GerAC like, C-terminal DUF1882 PF08966.11 ACT01752.1 - 0.048 13.9 0.1 0.12 12.6 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) GerA PF03323.13 ACT01753.1 - 1.4e-172 574.4 6.7 1.6e-172 574.2 6.7 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein PRTase_3 PF15610.6 ACT01753.1 - 0.25 10.5 1.6 2.5 7.3 0.1 2.3 3 0 0 3 3 3 0 PRTase ComF-like DUF1801 PF08818.11 ACT01754.1 - 1.4e-11 44.8 0.0 1.6e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DU1801) DinB PF05163.12 ACT01755.1 - 1.7e-24 86.7 0.0 2e-24 86.4 0.0 1.0 1 0 0 1 1 1 1 DinB family DinB_2 PF12867.7 ACT01755.1 - 4.8e-08 33.6 0.0 6.1e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 DinB superfamily DUF664 PF04978.12 ACT01755.1 - 0.0056 17.1 0.5 0.054 13.9 0.5 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF664) adh_short_C2 PF13561.6 ACT01756.1 - 5.3e-55 186.5 4.6 6.8e-55 186.2 4.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT01756.1 - 3.4e-46 157.2 1.9 4.6e-46 156.8 1.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT01756.1 - 1.7e-13 50.9 1.1 7.3e-13 48.8 0.5 1.9 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 ACT01756.1 - 0.00044 20.2 1.2 0.00055 19.9 1.2 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Pyr_redox PF00070.27 ACT01756.1 - 0.0016 19.0 0.7 0.0067 17.0 0.4 2.1 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase THF_DHG_CYH_C PF02882.19 ACT01756.1 - 0.016 14.5 0.2 0.035 13.4 0.1 1.6 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Pyr_redox_2 PF07992.14 ACT01756.1 - 0.022 14.0 0.5 0.038 13.2 0.5 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Toprim_3 PF13362.6 ACT01756.1 - 0.12 12.7 2.1 0.21 12.0 1.0 2.0 2 0 0 2 2 2 0 Toprim domain ADH_zinc_N PF00107.26 ACT01756.1 - 0.12 12.3 2.4 0.26 11.3 1.6 1.9 1 1 1 2 2 2 0 Zinc-binding dehydrogenase TetR_N PF00440.23 ACT01757.1 - 6.8e-15 54.6 0.0 1.6e-14 53.4 0.0 1.6 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family TetR_C_13 PF16925.5 ACT01757.1 - 5.1e-11 42.5 0.1 1.3e-10 41.2 0.1 1.7 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 ACT01757.1 - 0.012 15.7 0.1 0.029 14.5 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase TetR_C_17 PF17922.1 ACT01757.1 - 0.041 14.0 0.0 0.097 12.8 0.0 1.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain MlaA PF04333.13 ACT01757.1 - 0.066 12.9 0.0 0.095 12.4 0.0 1.2 1 0 0 1 1 1 0 MlaA lipoprotein TetR_C_25 PF17933.1 ACT01757.1 - 0.094 13.0 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain MFS_1 PF07690.16 ACT01758.1 - 4.1e-22 78.6 57.0 1.3e-19 70.4 29.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01758.1 - 1.2e-17 63.9 10.5 1.2e-17 63.9 10.5 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter APH PF01636.23 ACT01759.1 - 8.6e-21 74.9 0.0 1.1e-20 74.6 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 ACT01759.1 - 4.3e-11 42.6 0.2 9.5e-11 41.4 0.2 1.5 1 1 0 1 1 1 1 Fructosamine kinase APH_6_hur PF04655.14 ACT01759.1 - 0.0054 16.1 0.0 0.023 14.1 0.0 1.8 2 0 0 2 2 2 1 Aminoglycoside/hydroxyurea antibiotic resistance kinase RIO1 PF01163.22 ACT01759.1 - 0.012 15.2 0.0 0.053 13.1 0.0 1.8 2 0 0 2 2 2 0 RIO1 family DUF5010_C PF18099.1 ACT01760.1 - 9.7e-14 51.5 3.4 1e-05 25.6 0.2 3.1 2 0 0 2 2 2 2 DUF5010 C-terminal domain CBM_35 PF16990.5 ACT01760.1 - 3.8e-06 27.1 10.0 0.0037 17.5 1.7 3.1 2 0 0 2 2 2 2 Carbohydrate binding module (family 35) Crystall PF00030.19 ACT01760.1 - 0.0031 17.7 0.0 2 8.6 0.0 2.8 1 1 0 2 2 2 2 Beta/Gamma crystallin Crystall_3 PF08964.10 ACT01760.1 - 0.03 14.5 0.5 3.5 7.9 0.1 3.2 1 1 1 2 2 2 0 Beta/Gamma crystallin Inhibitor_I36 PF03995.13 ACT01760.1 - 0.18 11.7 12.2 0.033 14.1 1.8 4.1 2 1 2 4 4 4 0 Peptidase inhibitor family I36 EcsC PF12787.7 ACT01761.1 - 2e-79 266.7 0.0 2.3e-79 266.6 0.0 1.0 1 0 0 1 1 1 1 EcsC protein family NIPSNAP PF07978.13 ACT01762.1 - 1.4e-15 57.3 0.0 1.6e-15 57.2 0.0 1.0 1 0 0 1 1 1 1 NIPSNAP Flavodoxin_2 PF02525.17 ACT01763.1 - 9.4e-46 156.0 0.2 1.1e-45 155.8 0.2 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ACT01763.1 - 1.3e-05 25.0 0.0 2.4e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 NADPH-dependent FMN reductase DUF4965 PF16335.5 ACT01763.1 - 0.061 13.0 0.1 0.28 10.8 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4965) adh_short_C2 PF13561.6 ACT01764.1 - 1.8e-54 184.8 1.0 2.1e-54 184.5 1.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT01764.1 - 8.9e-54 181.9 0.9 1.1e-53 181.6 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT01764.1 - 1.3e-17 64.3 0.1 4.4e-17 62.6 0.1 1.7 1 1 1 2 2 2 1 KR domain Glyco_transf_5 PF08323.11 ACT01764.1 - 0.015 15.0 0.1 0.027 14.2 0.1 1.4 1 0 0 1 1 1 0 Starch synthase catalytic domain Epimerase PF01370.21 ACT01764.1 - 0.015 14.8 0.1 0.022 14.2 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 ACT01764.1 - 0.018 14.3 0.1 0.033 13.5 0.1 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 ACT01764.1 - 0.021 14.2 0.0 0.051 12.9 0.0 1.5 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) NAD_Gly3P_dh_N PF01210.23 ACT01764.1 - 0.026 14.5 0.3 0.21 11.5 0.0 2.1 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_3 PF13738.6 ACT01764.1 - 0.047 12.9 0.2 0.093 12.0 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ACT01764.1 - 0.05 13.5 1.2 0.12 12.2 0.4 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Hpr_kinase_C PF07475.12 ACT01764.1 - 0.06 12.9 0.1 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Smg4_UPF3 PF03467.15 ACT01764.1 - 0.064 13.3 0.0 0.092 12.8 0.0 1.2 1 0 0 1 1 1 0 Smg-4/UPF3 family GDP_Man_Dehyd PF16363.5 ACT01764.1 - 0.071 12.5 0.1 0.086 12.2 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase HEM4 PF02602.15 ACT01764.1 - 0.086 12.2 0.4 0.23 10.8 0.4 1.6 1 1 0 1 1 1 0 Uroporphyrinogen-III synthase HemD NIPSNAP PF07978.13 ACT01765.1 - 1.1e-15 57.7 0.0 1.2e-15 57.6 0.0 1.0 1 0 0 1 1 1 1 NIPSNAP NMO PF03060.15 ACT01766.1 - 2.1e-94 316.6 0.9 2.4e-94 316.5 0.9 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 ACT01766.1 - 4.1e-09 35.9 4.3 7.8e-09 35.0 4.3 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 ACT01766.1 - 3.4e-06 26.3 0.1 3.8e-05 22.9 0.1 2.1 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 ACT01766.1 - 0.0042 16.3 3.6 0.01 15.0 3.6 1.6 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 ACT01766.1 - 0.0044 16.5 0.1 0.0087 15.5 0.1 1.4 1 0 0 1 1 1 1 Histidine biosynthesis protein DUF561 PF04481.12 ACT01766.1 - 0.0052 16.0 0.2 0.012 14.8 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF561) DHO_dh PF01180.21 ACT01766.1 - 0.0097 15.1 0.6 0.016 14.4 0.6 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase TMP-TENI PF02581.17 ACT01766.1 - 0.14 11.5 2.3 0.58 9.5 1.5 2.5 2 1 1 3 3 3 0 Thiamine monophosphate synthase ThiG PF05690.14 ACT01766.1 - 1.2 8.4 6.3 4.5 6.5 5.9 2.1 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG LysR_substrate PF03466.20 ACT01767.1 - 2e-44 151.5 0.0 2.8e-44 151.0 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01767.1 - 4.6e-20 71.3 0.2 1.9e-19 69.3 0.2 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HR1 PF02185.16 ACT01767.1 - 0.15 12.2 0.9 0.36 11.0 0.9 1.6 1 0 0 1 1 1 0 Hr1 repeat MFS_4 PF06779.14 ACT01768.1 - 2e-87 293.9 38.3 2.3e-87 293.6 38.3 1.0 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_1 PF07690.16 ACT01768.1 - 6.4e-29 101.0 78.2 8.2e-20 71.0 42.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ACT01768.1 - 0.023 13.3 32.0 0.0025 16.5 25.8 2.5 1 1 1 2 2 2 0 MFS/sugar transport protein AveC_like PF17198.4 ACT01768.1 - 1.1 8.6 8.5 0.16 11.3 3.1 2.3 2 1 0 2 2 2 0 Spirocyclase AveC-like GerA PF03323.13 ACT01769.1 - 1.2e-181 604.3 4.0 1.5e-181 604.0 4.0 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein DUF417 PF04224.12 ACT01769.1 - 0.06 12.9 4.4 0.11 12.0 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF417 MtrG PF04210.13 ACT01769.1 - 8.6 6.3 6.8 2.1 8.2 0.3 2.5 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G CrgA PF06781.12 ACT01770.1 - 0.049 13.7 1.2 0.054 13.6 0.2 1.5 1 1 0 1 1 1 0 Cell division protein CrgA PsbY PF06298.11 ACT01770.1 - 0.049 13.5 0.2 0.049 13.5 0.2 1.8 2 0 0 2 2 2 0 Photosystem II protein Y (PsbY) DUF2842 PF11003.8 ACT01770.1 - 0.36 11.1 7.1 6.1 7.2 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2842) DUF418 PF04235.12 ACT01770.1 - 1 9.3 5.7 1.5 8.8 5.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF418) Spore_permease PF03845.13 ACT01771.1 - 1.2e-48 165.6 36.7 1.7e-48 165.1 36.7 1.2 1 0 0 1 1 1 1 Spore germination protein YtpI PF14007.6 ACT01771.1 - 0.24 11.6 8.3 0.15 12.2 1.7 3.0 2 0 0 2 2 2 0 YtpI-like protein HTH_42 PF06224.12 ACT01772.1 - 4.2e-69 233.6 3.4 5e-69 233.3 3.4 1.1 1 0 0 1 1 1 1 Winged helix DNA-binding domain Trans_reg_C PF00486.28 ACT01773.1 - 2.1e-25 88.6 0.0 7.5e-25 86.8 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 ACT01773.1 - 6.1e-24 84.3 0.0 1.1e-23 83.5 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain UL11 PF11094.8 ACT01773.1 - 0.049 13.5 0.0 0.096 12.6 0.0 1.5 1 0 0 1 1 1 0 Membrane-associated tegument protein GerE PF00196.19 ACT01773.1 - 0.17 11.5 0.4 0.49 10.0 0.0 2.0 3 0 0 3 3 3 0 Bacterial regulatory proteins, luxR family HATPase_c PF02518.26 ACT01774.1 - 7.5e-20 71.5 0.0 2.8e-19 69.7 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT01774.1 - 7.4e-11 41.9 5.6 1e-10 41.5 0.1 3.3 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT01774.1 - 1.6e-09 38.0 0.4 3.3e-09 37.0 0.4 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c_5 PF14501.6 ACT01774.1 - 6.6e-07 29.2 0.0 1.4e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 GHKL domain dCache_1 PF02743.18 ACT01774.1 - 0.028 14.2 3.5 4.4 7.0 0.0 2.4 2 0 0 2 2 2 0 Cache domain DUF4686 PF15742.5 ACT01774.1 - 0.22 10.6 0.0 0.33 10.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) PD40 PF07676.12 ACT01775.1 - 0.0013 18.6 0.0 0.47 10.5 0.0 2.8 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat RAMA PF18755.1 ACT01775.1 - 0.02 15.3 0.0 0.062 13.7 0.0 1.8 2 0 0 2 2 2 0 Restriction Enzyme Adenine Methylase Associated PQQ_2 PF13360.6 ACT01775.1 - 0.092 12.3 0.0 0.21 11.2 0.0 1.6 1 1 0 1 1 1 0 PQQ-like domain SBP_bac_1 PF01547.25 ACT01776.1 - 1.9e-18 67.5 4.0 6.1e-18 65.8 4.0 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT01777.1 - 1.3e-16 60.9 8.6 1.3e-16 60.9 8.6 1.6 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Gram_pos_anchor PF00746.21 ACT01777.1 - 8.8 6.4 6.4 17 5.4 2.1 2.7 2 0 0 2 2 2 0 LPXTG cell wall anchor motif BPD_transp_1 PF00528.22 ACT01778.1 - 5.6e-18 65.3 10.7 5.6e-18 65.3 10.7 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Biotin_lipoyl_2 PF13533.6 ACT01779.1 - 9e-10 38.2 0.7 3.5e-06 26.8 0.1 3.5 3 0 0 3 3 3 2 Biotin-lipoyl like HlyD_D23 PF16576.5 ACT01779.1 - 3.6e-06 26.4 0.8 8.3e-06 25.2 0.8 1.5 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_2 PF12700.7 ACT01779.1 - 3.4e-05 22.8 0.4 0.00024 20.0 0.1 2.0 2 0 0 2 2 2 1 HlyD family secretion protein Biotin_lipoyl PF00364.22 ACT01779.1 - 0.00063 19.5 0.2 0.021 14.6 0.0 2.8 2 0 0 2 2 2 1 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 ACT01779.1 - 0.0048 16.6 0.2 0.021 14.6 0.1 2.2 2 0 0 2 2 2 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 RnfC_N PF13375.6 ACT01779.1 - 0.0053 16.7 0.4 0.075 13.0 0.0 2.7 3 0 0 3 3 3 1 RnfC Barrel sandwich hybrid domain HlyD_3 PF13437.6 ACT01779.1 - 0.0087 16.7 0.1 0.8 10.4 0.0 2.8 2 1 0 2 2 2 1 HlyD family secretion protein Peptidase_M23 PF01551.22 ACT01779.1 - 0.11 12.7 0.3 3.2 8.0 0.1 2.6 2 0 0 2 2 2 0 Peptidase family M23 LSM PF01423.22 ACT01779.1 - 0.12 12.0 0.4 1.5 8.5 0.3 2.4 2 0 0 2 2 2 0 LSM domain GPDPase_memb PF10110.9 ACT01780.1 - 5.1e-40 137.2 36.0 7e-40 136.8 36.0 1.2 1 0 0 1 1 1 1 Membrane domain of glycerophosphoryl diester phosphodiesterase GDPD PF03009.17 ACT01780.1 - 7.7e-35 120.9 0.3 1.6e-33 116.6 0.3 2.5 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ACT01780.1 - 0.077 13.5 0.1 0.24 11.9 0.1 1.9 1 1 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family LRR19-TM PF15176.6 ACT01780.1 - 8.2 6.5 6.1 0.59 10.1 0.3 2.1 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain tRNA-synt_1g PF09334.11 ACT01781.1 - 4.2e-140 466.9 0.0 5.2e-140 466.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ACT01781.1 - 8.8e-14 50.7 0.4 7.4e-08 31.1 0.1 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 ACT01781.1 - 2.3e-08 33.7 0.0 0.00074 19.0 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 ACT01781.1 - 1.6e-07 31.4 0.0 3.4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA RecR PF02132.15 ACT01781.1 - 0.026 14.1 5.2 0.14 11.7 1.6 2.5 2 0 0 2 2 2 0 RecR protein tRNA-synt_1f PF01921.18 ACT01781.1 - 0.028 13.3 0.0 1.9 7.3 0.0 2.9 3 0 0 3 3 3 0 tRNA synthetases class I (K) DZR PF12773.7 ACT01781.1 - 0.085 12.9 6.1 0.33 11.0 6.1 2.0 1 1 0 1 1 1 0 Double zinc ribbon Laminin_EGF PF00053.24 ACT01781.1 - 0.7 10.1 5.8 1.6 9.0 5.8 1.6 1 0 0 1 1 1 0 Laminin EGF domain GerA PF03323.13 ACT01783.1 - 1.1e-178 594.5 3.1 1.3e-178 594.3 3.1 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_permease PF03845.13 ACT01784.1 - 2.7e-57 194.0 29.6 4e-57 193.5 29.6 1.2 1 0 0 1 1 1 1 Spore germination protein Aa_trans PF01490.18 ACT01784.1 - 0.003 16.3 31.2 0.0084 14.9 31.2 1.7 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Spore_GerAC PF05504.11 ACT01785.1 - 1.1e-27 97.2 0.2 1.6e-27 96.7 0.2 1.2 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal TMEMspv1-c74-12 PF11044.8 ACT01786.1 - 0.029 14.3 5.9 0.037 14.0 0.4 2.1 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Ceramidase PF05875.12 ACT01786.1 - 0.062 12.7 0.1 0.067 12.6 0.1 1.0 1 0 0 1 1 1 0 Ceramidase DUF3784 PF12650.7 ACT01786.1 - 0.17 12.1 3.6 1.6 9.0 2.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3784) DUF3953 PF13129.6 ACT01786.1 - 3.1 7.6 7.9 53 3.7 7.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3953) DUF4972 PF16342.5 ACT01787.1 - 0.008 15.9 0.8 0.012 15.3 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4972) AI-2E_transport PF01594.16 ACT01787.1 - 0.02 14.1 0.2 0.02 14.1 0.2 1.9 1 1 1 2 2 2 0 AI-2E family transporter MscS_porin PF12795.7 ACT01787.1 - 0.033 13.8 12.5 0.059 12.9 12.5 1.4 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain zf-CCCH_7 PF18586.1 ACT01787.1 - 0.057 13.8 0.1 0.09 13.1 0.1 1.3 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 ABC_tran_CTD PF16326.5 ACT01787.1 - 0.057 13.7 0.9 0.057 13.7 0.9 2.2 2 1 0 2 2 2 0 ABC transporter C-terminal domain DUF948 PF06103.11 ACT01787.1 - 0.29 11.4 4.4 0.83 10.0 0.6 2.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Sec2p PF06428.11 ACT01787.1 - 4.3 7.4 8.8 0.53 10.3 1.6 2.2 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p TetR_C_8 PF14278.6 ACT01788.1 - 3.9e-16 59.0 1.0 3.9e-16 59.0 1.0 1.8 2 0 0 2 2 2 1 Transcriptional regulator C-terminal region TetR_N PF00440.23 ACT01788.1 - 3.5e-11 42.7 0.0 6.2e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_Tnp_1_2 PF13022.6 ACT01788.1 - 0.0015 18.7 0.1 0.0026 17.9 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase HTH_40 PF14493.6 ACT01788.1 - 0.012 16.0 0.0 0.029 14.8 0.0 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_11 PF08279.12 ACT01788.1 - 0.013 15.4 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 HTH domain HTH_24 PF13412.6 ACT01788.1 - 0.044 13.4 0.1 0.53 9.9 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Sigma70_r4 PF04545.16 ACT01788.1 - 0.052 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_IclR PF09339.10 ACT01788.1 - 0.24 11.2 0.0 0.49 10.2 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain adh_short PF00106.25 ACT01789.1 - 2e-58 197.1 2.0 2.7e-58 196.7 2.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT01789.1 - 2.6e-45 154.8 3.7 3.1e-45 154.6 3.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT01789.1 - 6.9e-17 61.9 1.2 9.2e-17 61.5 1.2 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ACT01789.1 - 1.3e-07 31.7 1.5 1.6e-07 31.4 1.5 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ACT01789.1 - 6.1e-06 25.9 0.2 1.8e-05 24.3 0.2 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 ACT01789.1 - 0.00017 21.9 0.3 0.00036 20.8 0.2 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ACT01789.1 - 0.013 15.6 0.3 0.033 14.3 0.3 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 ACT01789.1 - 0.017 14.3 0.3 0.02 14.0 0.3 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 ACT01789.1 - 0.02 14.2 0.1 0.039 13.3 0.1 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.19 ACT01789.1 - 0.042 13.2 0.3 0.072 12.5 0.3 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ACT01789.1 - 0.048 13.2 0.7 0.1 12.2 0.7 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DUF881 PF05949.12 ACT01789.1 - 0.052 13.4 0.2 0.11 12.3 0.1 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF881) 3HCDH_N PF02737.18 ACT01789.1 - 0.057 13.3 0.4 0.15 12.0 0.2 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 ACT01789.1 - 0.077 12.6 0.0 0.2 11.3 0.1 1.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA GDP_Man_Dehyd PF16363.5 ACT01789.1 - 0.13 11.7 0.2 0.32 10.3 0.2 1.6 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase MarR_2 PF12802.7 ACT01790.1 - 6.1e-09 35.6 0.1 1e-08 34.9 0.1 1.3 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.6 ACT01790.1 - 9.1e-08 32.2 0.0 1.3e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.22 ACT01790.1 - 1.8e-07 31.0 0.2 4e-07 29.9 0.0 1.6 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 ACT01790.1 - 3.9e-07 30.5 0.0 6.2e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_IclR PF09339.10 ACT01790.1 - 5.3e-05 22.9 0.1 0.00012 21.8 0.1 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain HxlR PF01638.17 ACT01790.1 - 0.00058 19.7 0.0 0.00076 19.3 0.0 1.2 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_5 PF01022.20 ACT01790.1 - 0.00059 19.6 0.1 0.0022 17.8 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_Crp_2 PF13545.6 ACT01790.1 - 0.0011 18.9 0.1 0.0034 17.3 0.1 1.8 1 1 1 2 2 2 1 Crp-like helix-turn-helix domain HTH_20 PF12840.7 ACT01790.1 - 0.0027 17.7 0.3 0.013 15.6 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain TrmB PF01978.19 ACT01790.1 - 0.01 15.7 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_CodY PF08222.11 ACT01790.1 - 0.03 13.9 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain HTH_24 PF13412.6 ACT01790.1 - 0.037 13.6 0.1 0.16 11.6 0.1 2.1 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 ACT01790.1 - 0.1 12.6 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 HTH domain adh_short_C2 PF13561.6 ACT01791.1 - 3.4e-57 193.7 1.2 4.2e-57 193.4 1.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT01791.1 - 4.4e-49 166.6 2.0 5.6e-49 166.3 2.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT01791.1 - 5e-10 39.6 0.8 1.2e-09 38.3 0.8 1.6 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 ACT01791.1 - 0.0001 21.8 0.0 0.00014 21.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ACT01791.1 - 0.0022 17.2 0.3 0.0036 16.5 0.3 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein AlaDh_PNT_C PF01262.21 ACT01791.1 - 0.0061 15.9 1.2 0.0093 15.3 1.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain RmlD_sub_bind PF04321.17 ACT01791.1 - 0.029 13.5 0.1 0.15 11.1 0.1 1.9 1 1 0 1 1 1 0 RmlD substrate binding domain 3HCDH_N PF02737.18 ACT01791.1 - 0.043 13.7 0.3 0.45 10.4 0.4 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 ACT01791.1 - 0.052 13.5 0.4 0.1 12.6 0.4 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Eno-Rase_NADH_b PF12242.8 ACT01791.1 - 0.12 12.1 2.9 7.3 6.4 0.6 3.1 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase CMD PF02627.20 ACT01792.1 - 1.9e-18 66.3 0.3 5.8e-17 61.5 0.1 2.1 2 0 0 2 2 2 2 Carboxymuconolactone decarboxylase family NAD_binding_10 PF13460.6 ACT01793.1 - 1.5e-13 51.0 2.6 1.3e-11 44.8 2.6 2.7 2 1 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 ACT01793.1 - 3e-09 36.8 1.9 5.2e-07 29.5 2.0 2.2 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 ACT01793.1 - 0.00033 20.2 2.1 0.0021 17.5 2.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ACT01793.1 - 0.00035 19.8 0.1 0.041 13.0 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain DapB_N PF01113.20 ACT01793.1 - 0.025 14.7 4.1 0.084 13.0 1.6 2.7 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.19 ACT01793.1 - 0.42 9.6 1.7 1.5 7.8 1.4 2.1 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PMSR PF01625.21 ACT01794.1 - 4.9e-58 195.7 0.1 5.7e-58 195.4 0.1 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase BPD_transp_1 PF00528.22 ACT01795.1 - 3.2e-22 79.1 19.0 4.1e-22 78.8 19.0 1.2 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component FtsX PF02687.21 ACT01795.1 - 0.44 11.1 26.0 0.18 12.3 2.8 3.3 2 1 0 2 2 2 0 FtsX-like permease family Cupredoxin_1 PF13473.6 ACT01796.1 - 2.4e-25 88.6 0.1 3.1e-25 88.3 0.1 1.1 1 0 0 1 1 1 1 Cupredoxin-like domain FtsH_ext PF06480.15 ACT01796.1 - 0.016 15.6 0.2 0.025 14.9 0.2 1.4 1 1 0 1 1 1 0 FtsH Extracellular DUF2140 PF09911.9 ACT01796.1 - 0.11 12.0 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) PepSY_2 PF13670.6 ACT01796.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain Erythro_esteras PF05139.14 ACT01797.1 - 2.1e-43 149.5 1.3 1.1e-41 143.8 0.3 2.1 1 1 1 2 2 2 2 Erythromycin esterase ACT PF01842.25 ACT01798.1 - 0.0061 16.3 0.4 0.1 12.4 0.1 2.1 2 0 0 2 2 2 1 ACT domain DUF2007 PF09413.10 ACT01798.1 - 0.1 12.7 0.4 0.18 12.0 0.1 1.7 2 0 0 2 2 2 0 Putative prokaryotic signal transducing protein Radical_SAM PF04055.21 ACT01799.1 - 0.00016 22.1 0.4 0.0019 18.6 0.2 2.4 2 1 0 2 2 2 1 Radical SAM superfamily Glyco_hydro_3 PF00933.21 ACT01800.1 - 1.4e-92 310.5 0.2 1.6e-92 310.3 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain HTH_18 PF12833.7 ACT01801.1 - 4.5e-19 68.5 0.6 1.6e-18 66.8 0.1 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01801.1 - 7.2e-12 45.1 1.7 4.1e-10 39.5 0.2 4.0 4 0 0 4 4 4 1 Bacterial regulatory helix-turn-helix proteins, AraC family dCache_1 PF02743.18 ACT01801.1 - 1.6e-07 31.4 3.4 1.9e-07 31.2 1.6 2.0 2 0 0 2 2 2 1 Cache domain GGDEF_2 PF17853.1 ACT01801.1 - 9.7e-06 25.8 0.1 5.8e-05 23.3 0.1 2.4 2 0 0 2 2 2 1 GGDEF-like domain DUF883 PF05957.13 ACT01801.1 - 0.03 14.9 1.1 0.34 11.6 0.2 3.3 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) DNAPolymera_Pol PF11590.8 ACT01801.1 - 0.41 10.6 2.8 1.5 8.8 2.8 1.9 1 0 0 1 1 1 0 DNA polymerase catalytic subunit Pol SBP_bac_8 PF13416.6 ACT01802.1 - 1.3e-13 51.4 0.1 2.3e-13 50.6 0.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT01802.1 - 2.2e-10 41.0 3.0 3.5e-10 40.3 3.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT01802.1 - 1.3e-05 25.9 0.0 2.8e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) BPD_transp_1 PF00528.22 ACT01803.1 - 2.6e-10 40.3 17.0 2.6e-10 40.3 17.0 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component 2TM PF13239.6 ACT01803.1 - 0.00018 21.7 1.9 0.00018 21.7 1.9 2.9 3 1 0 3 3 3 1 2TM domain DHHC PF01529.20 ACT01803.1 - 0.68 10.0 12.3 0.022 14.8 5.0 2.2 2 1 1 3 3 3 0 DHHC palmitoyltransferase BPD_transp_1 PF00528.22 ACT01804.1 - 5.2e-12 45.9 22.6 2e-10 40.7 22.6 2.1 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component COX7a PF02238.15 ACT01804.1 - 5.4 7.5 6.3 37 4.8 0.3 3.1 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII SBP_bac_8 PF13416.6 ACT01805.1 - 9.7e-21 74.8 4.2 9.7e-21 74.8 4.2 1.7 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT01805.1 - 4.6e-18 66.2 7.4 4.6e-18 66.2 7.4 1.6 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein DUF4969 PF16339.5 ACT01805.1 - 0.081 13.3 0.0 0.3 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4969) 2-oxogl_dehyd_N PF16078.5 ACT01805.1 - 0.11 12.1 0.0 0.69 9.6 0.0 2.4 2 1 0 2 2 2 0 2-oxoglutarate dehydrogenase N-terminus NHL PF01436.21 ACT01806.1 - 0.043 13.9 0.0 0.19 11.9 0.0 2.1 1 0 0 1 1 1 0 NHL repeat Pentapeptide PF00805.22 ACT01807.1 - 2.5e-63 209.2 50.6 1.1e-11 44.2 0.2 9.5 8 1 0 9 9 9 8 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ACT01807.1 - 2.7e-34 117.2 7.3 2.7e-08 33.9 2.0 7.1 3 3 4 8 8 8 6 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ACT01807.1 - 4.6e-31 106.7 21.6 3.1e-06 27.3 0.2 9.2 6 3 3 9 9 9 8 Pentapeptide repeats (9 copies) CfAFP PF05264.11 ACT01807.1 - 0.0051 16.8 0.0 6 6.8 0.0 3.8 2 2 2 4 4 4 1 Choristoneura fumiferana antifreeze protein (CfAFP) DNA_ligase_OB PF03120.16 ACT01807.1 - 0.072 13.0 0.2 2.6 8.0 0.0 3.4 3 1 0 3 3 3 0 NAD-dependent DNA ligase OB-fold domain Spore_permease PF03845.13 ACT01808.1 - 4e-45 154.0 31.6 4.9e-45 153.8 31.6 1.1 1 0 0 1 1 1 1 Spore germination protein Spore_GerAC PF05504.11 ACT01809.1 - 2.9e-34 118.7 0.1 3.9e-34 118.2 0.1 1.2 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal PTPlike_phytase PF14566.6 ACT01809.1 - 0.044 13.9 0.1 0.18 12.0 0.1 1.8 2 0 0 2 2 2 0 Inositol hexakisphosphate FPRL1_inhibitor PF16104.5 ACT01809.1 - 0.13 12.4 0.1 3.7 7.7 0.0 2.3 2 0 0 2 2 2 0 Formyl peptide receptor-like 1 inhibitory protein GerA PF03323.13 ACT01810.1 - 6.1e-174 578.9 1.5 6.9e-174 578.7 1.5 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein ABC2_membrane_6 PF06182.11 ACT01811.1 - 4.2e-48 164.1 10.4 5.2e-48 163.8 10.4 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF1772 PF08592.11 ACT01811.1 - 0.97 9.8 9.8 3 8.2 0.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) DUF423 PF04241.15 ACT01811.1 - 6.7 7.0 7.5 0.85 9.9 0.9 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF423) ABC2_membrane PF01061.24 ACT01812.1 - 0.00037 20.0 25.2 0.00066 19.1 25.2 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ACT01812.1 - 0.06 12.5 34.2 18 4.3 34.2 2.0 1 1 0 1 1 1 0 ABC-2 family transporter protein ABC_tran PF00005.27 ACT01813.1 - 2.9e-26 92.6 0.0 4.6e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01813.1 - 4e-12 46.6 0.2 1.4e-07 31.6 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT01813.1 - 0.0011 18.7 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 ACT01813.1 - 0.0089 16.5 0.9 0.64 10.4 0.1 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ACT01813.1 - 0.013 15.4 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain DUF4162 PF13732.6 ACT01813.1 - 0.014 16.1 0.0 0.053 14.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) AAA_15 PF13175.6 ACT01813.1 - 0.046 13.4 0.2 4.5 6.9 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain SMC_N PF02463.19 ACT01813.1 - 0.052 13.0 0.5 5.7 6.3 0.1 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain MukB PF04310.12 ACT01813.1 - 0.081 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 MukB N-terminal AAA_30 PF13604.6 ACT01813.1 - 0.14 11.8 0.0 0.24 11.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ACT01813.1 - 0.26 11.8 0.1 0.46 11.0 0.1 1.3 1 0 0 1 1 1 0 AAA domain DUF2642 PF10842.8 ACT01814.1 - 0.0028 17.4 0.0 0.0044 16.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2642) Glycos_transf_2 PF00535.26 ACT01816.1 - 3.1e-33 115.0 0.0 4.2e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACT01816.1 - 2.1e-12 47.4 0.0 3.8e-12 46.6 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ACT01816.1 - 5.4e-07 29.4 0.0 0.0014 18.1 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ACT01816.1 - 0.19 11.6 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family group 2 Glyco_transf_4 PF13439.6 ACT01817.1 - 4.5e-18 65.8 0.0 1e-17 64.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACT01817.1 - 4.7e-15 56.4 1.8 2.4e-14 54.1 0.1 2.1 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.20 ACT01817.1 - 4.6e-13 49.1 0.0 1e-12 47.9 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT01817.1 - 2.2e-10 41.1 1.6 3e-10 40.6 0.1 2.0 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 ACT01817.1 - 5.9e-09 36.1 0.0 1.2e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like PIGA PF08288.12 ACT01817.1 - 0.0068 17.0 0.0 0.015 15.9 0.0 1.5 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Peripla_BP_4 PF13407.6 ACT01817.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein domain DUF1203 PF06718.11 ACT01817.1 - 0.12 12.7 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1203) PS_pyruv_trans PF04230.13 ACT01818.1 - 7e-23 81.9 0.0 9.5e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide pyruvyl transferase HATPase_c PF02518.26 ACT01819.1 - 4.9e-21 75.3 0.1 9e-21 74.5 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT01819.1 - 1.1e-11 44.6 0.0 3.8e-11 42.9 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain 5TM-5TMR_LYT PF07694.12 ACT01819.1 - 2.6e-10 40.1 8.7 5.7e-10 39.0 8.7 1.5 1 1 0 1 1 1 1 5TMR of 5TMR-LYT PAS_9 PF13426.7 ACT01819.1 - 9.9e-10 38.6 0.0 2.5e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 ACT01819.1 - 2.1e-09 37.4 0.0 4.3e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 ACT01819.1 - 6.2e-09 36.0 0.0 1.3e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 ACT01819.1 - 1.9e-08 34.5 0.0 3.5e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 PAS fold HATPase_c_5 PF14501.6 ACT01819.1 - 1.4e-06 28.1 0.1 1.8e-05 24.6 0.1 2.3 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 ACT01819.1 - 0.023 14.5 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CutC PF03932.14 ACT01820.1 - 8.3e-58 195.2 1.2 9.8e-58 195.0 1.2 1.0 1 0 0 1 1 1 1 CutC family PdxJ PF03740.13 ACT01820.1 - 0.068 12.3 0.0 0.16 11.0 0.0 1.6 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthesis protein PdxJ PPDK_N PF01326.19 ACT01821.1 - 2.4e-88 296.6 0.0 4.2e-88 295.8 0.0 1.3 1 0 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.23 ACT01821.1 - 3.4e-23 81.1 0.0 4.4e-22 77.6 0.2 2.5 2 0 0 2 2 2 1 PEP-utilising enzyme, mobile domain TBCC_N PF16752.5 ACT01821.1 - 1.7 9.1 4.7 27 5.2 0.1 3.4 4 0 0 4 4 4 0 Tubulin-specific chaperone C N-terminal domain Pedibin PF08182.11 ACT01822.1 - 0.13 12.0 3.4 0.15 11.9 2.6 1.6 1 1 0 1 1 1 0 Pedibin/Hym-346 family WYL PF13280.6 ACT01823.1 - 0.0088 16.1 0.1 0.012 15.7 0.1 1.1 1 0 0 1 1 1 1 WYL domain HrcA_DNA-bdg PF03444.15 ACT01824.1 - 0.0017 18.0 0.0 0.0018 17.9 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HTH_24 PF13412.6 ACT01824.1 - 0.0025 17.3 0.2 0.0035 16.9 0.2 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding SgrR_N PF12793.7 ACT01824.1 - 0.0099 16.1 0.0 0.012 15.8 0.0 1.1 1 0 0 1 1 1 1 Sugar transport-related sRNA regulator N-term MarR PF01047.22 ACT01824.1 - 0.017 15.0 0.0 0.02 14.8 0.0 1.1 1 0 0 1 1 1 0 MarR family RuvB_C PF05491.13 ACT01824.1 - 0.05 13.5 0.0 0.06 13.2 0.0 1.1 1 0 0 1 1 1 0 RuvB C-terminal winged helix domain MarR_2 PF12802.7 ACT01824.1 - 0.095 12.6 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 MarR family Phage_rep_org_N PF09681.10 ACT01824.1 - 0.11 12.4 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 N-terminal phage replisome organiser (Phage_rep_org_N) HTH_27 PF13463.6 ACT01824.1 - 0.15 12.6 0.1 0.16 12.5 0.1 1.1 1 0 0 1 1 1 0 Winged helix DNA-binding domain Ferritin PF00210.24 ACT01825.1 - 9.4e-33 113.1 5.8 1e-32 113.0 5.8 1.0 1 0 0 1 1 1 1 Ferritin-like domain Apolipoprotein PF01442.18 ACT01825.1 - 0.0027 17.6 1.5 0.0049 16.8 1.5 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF1048 PF06304.11 ACT01825.1 - 0.0055 17.1 1.2 0.084 13.3 0.2 2.4 1 1 1 3 3 3 1 Protein of unknown function (DUF1048) MCM6_C PF18263.1 ACT01825.1 - 0.026 14.8 1.0 0.062 13.5 1.0 1.7 1 1 0 1 1 1 0 MCM6 C-terminal winged-helix domain HTH_20 PF12840.7 ACT01825.1 - 0.031 14.3 0.0 0.065 13.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain KNTase_C PF07827.11 ACT01825.1 - 0.053 13.4 0.5 0.1 12.5 0.2 1.7 1 1 1 2 2 2 0 KNTase C-terminal domain DUF148 PF02520.17 ACT01825.1 - 0.15 12.2 2.1 0.14 12.3 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function DUF148 PhetRS_B1 PF18262.1 ACT01825.1 - 0.57 10.4 3.0 0.82 9.9 1.1 2.0 1 1 1 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain RNase_J_C PF17770.1 ACT01825.1 - 0.57 11.3 1.7 39 5.4 0.0 3.0 2 1 1 3 3 3 0 Ribonuclease J C-terminal domain Helicase_C_2 PF13307.6 ACT01826.1 - 1.3e-37 129.6 0.0 3.9e-37 128.0 0.0 1.8 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 ACT01826.1 - 3.4e-13 49.6 0.6 9.4e-13 48.2 0.6 1.8 1 1 0 1 1 1 1 DEAD_2 DEAD PF00270.29 ACT01826.1 - 4.9e-06 26.4 0.2 0.00017 21.4 0.1 2.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 ACT01826.1 - 0.0062 16.6 0.6 0.074 13.0 0.5 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ACT01826.1 - 0.021 15.2 0.0 0.055 13.8 0.0 1.7 1 0 0 1 1 1 0 Helicase conserved C-terminal domain PhoH PF02562.16 ACT01826.1 - 0.13 11.7 0.2 0.27 10.7 0.2 1.4 1 0 0 1 1 1 0 PhoH-like protein FCD PF07729.12 ACT01827.1 - 7.7e-20 71.6 0.6 1.1e-19 71.0 0.6 1.2 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 ACT01827.1 - 2e-16 59.4 0.2 4e-16 58.4 0.0 1.6 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Rrf2 PF02082.20 ACT01827.1 - 0.005 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator TrmB PF01978.19 ACT01827.1 - 0.018 14.9 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 ACT01827.1 - 0.049 13.6 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 HTH domain HTH_Crp_2 PF13545.6 ACT01827.1 - 0.053 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain DMPK_coil PF08826.10 ACT01827.1 - 0.056 13.6 0.3 0.17 12.0 0.3 1.9 1 0 0 1 1 1 0 DMPK coiled coil domain like HTH_24 PF13412.6 ACT01827.1 - 0.078 12.6 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding ILVD_EDD PF00920.21 ACT01828.1 - 1.5e-218 726.6 1.1 1.7e-218 726.5 1.1 1.0 1 0 0 1 1 1 1 Dehydratase family DUF2188 PF09954.9 ACT01829.1 - 0.0022 18.1 0.1 0.0068 16.5 0.1 1.8 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2188) Phg_2220_C PF09524.10 ACT01829.1 - 0.093 12.8 0.1 0.1 12.6 0.1 1.2 1 0 0 1 1 1 0 Conserved phage C-terminus (Phg_2220_C) Response_reg PF00072.24 ACT01830.1 - 8.3e-27 93.6 0.1 1.4e-26 92.8 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT01830.1 - 9.6e-23 80.1 1.2 1.8e-22 79.2 1.2 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HATPase_c PF02518.26 ACT01831.1 - 2.8e-20 72.9 0.1 1.1e-19 70.9 0.0 2.1 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT01831.1 - 1.7e-12 47.5 0.0 3.3e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 HAMP domain HisKA PF00512.25 ACT01831.1 - 7.8e-11 41.9 0.1 3.4e-10 39.8 0.0 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ACT01831.1 - 8.1e-05 22.5 0.0 0.00019 21.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4635 PF15466.6 ACT01831.1 - 0.074 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) zf-CCHC_5 PF14787.6 ACT01832.1 - 0.093 12.4 0.0 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger DUF421 PF04239.12 ACT01834.1 - 4.3e-31 106.9 0.0 6e-31 106.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF421) Transpeptidase PF00905.22 ACT01835.1 - 4.9e-83 278.8 2.7 9.1e-83 278.0 2.7 1.5 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 ACT01835.1 - 9.4e-19 68.4 8.1 2.2e-17 64.0 7.6 2.7 1 1 0 1 1 1 1 Penicillin-binding Protein dimerisation domain PASTA PF03793.19 ACT01835.1 - 5.7e-14 51.7 0.8 8.8e-08 31.9 0.1 2.8 2 0 0 2 2 2 2 PASTA domain adh_short_C2 PF13561.6 ACT01836.1 - 5e-47 160.4 2.6 6.1e-47 160.1 2.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT01836.1 - 8.5e-37 126.5 1.6 1.1e-36 126.2 1.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT01836.1 - 1.3e-12 48.0 1.5 1.8e-12 47.6 1.5 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ACT01836.1 - 0.00019 21.4 0.9 0.00024 21.1 0.9 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ACT01836.1 - 0.00028 20.4 2.2 0.00082 18.9 2.1 1.8 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ACT01836.1 - 0.0018 17.4 0.3 0.0026 17.0 0.3 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 ACT01836.1 - 0.002 18.7 0.8 0.0054 17.3 0.8 1.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DUF1776 PF08643.10 ACT01836.1 - 0.003 17.0 0.0 0.0044 16.4 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 ACT01836.1 - 0.0041 16.7 1.5 0.017 14.7 0.6 2.2 2 1 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 ACT01836.1 - 0.013 14.7 0.0 0.021 14.0 0.0 1.5 1 0 0 1 1 1 0 Male sterility protein 3Beta_HSD PF01073.19 ACT01836.1 - 0.04 12.9 0.1 0.055 12.5 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family ATF7IP_BD PF16788.5 ACT01836.1 - 0.066 13.3 0.1 0.094 12.8 0.1 1.2 1 0 0 1 1 1 0 ATF-interacting protein binding domain 3HCDH_N PF02737.18 ACT01836.1 - 0.076 12.9 0.6 0.13 12.1 0.6 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ACT01836.1 - 0.11 11.8 0.2 0.22 10.9 0.1 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lyase_8_N PF08124.11 ACT01837.1 - 5.3e-89 298.3 0.5 1e-88 297.4 0.5 1.5 1 0 0 1 1 1 1 Polysaccharide lyase family 8, N terminal alpha-helical domain Lyase_8 PF02278.18 ACT01837.1 - 5.2e-86 288.3 3.5 5.2e-86 288.3 3.5 1.8 2 0 0 2 2 2 1 Polysaccharide lyase family 8, super-sandwich domain SLH PF00395.20 ACT01837.1 - 5.8e-39 131.9 1.9 9.4e-15 54.3 0.4 3.8 3 0 0 3 3 3 3 S-layer homology domain Lyase_8_C PF02884.17 ACT01837.1 - 1.9e-22 79.5 2.4 1.1e-21 77.1 0.0 3.5 4 0 0 4 4 4 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain DUF5011 PF16403.5 ACT01837.1 - 0.00028 20.9 0.1 0.0051 16.9 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF5011) IreB PF06135.12 ACT01837.1 - 0.024 14.8 0.0 0.92 9.7 0.0 2.7 2 0 0 2 2 2 0 IreB regulatory phosphoprotein Aminotran_1_2 PF00155.21 ACT01838.1 - 2.7e-21 76.2 0.0 3.5e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II GntR PF00392.21 ACT01838.1 - 5.5e-14 51.6 0.0 1.3e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Aminotran_MocR PF12897.7 ACT01838.1 - 4.6e-06 25.7 0.0 0.00012 21.0 0.0 2.2 2 0 0 2 2 2 1 Alanine-glyoxylate amino-transferase HTH_24 PF13412.6 ACT01838.1 - 0.0032 17.0 0.0 0.0087 15.6 0.0 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding DmpG_comm PF07836.11 ACT01838.1 - 0.016 14.7 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 DmpG-like communication domain HTH_Crp_2 PF13545.6 ACT01838.1 - 0.018 15.0 0.0 0.086 12.8 0.0 2.2 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain Cys_Met_Meta_PP PF01053.20 ACT01838.1 - 0.049 12.2 0.0 0.075 11.6 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme HTH_36 PF13730.6 ACT01838.1 - 0.1 12.6 0.0 0.65 10.0 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Amino_oxidase PF01593.24 ACT01839.1 - 6.6e-42 144.3 0.0 9.9e-28 97.6 0.0 2.0 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ACT01839.1 - 2.9e-14 53.0 0.0 7.3e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ACT01839.1 - 9.6e-06 25.1 0.1 2.2e-05 23.9 0.3 1.4 2 0 0 2 2 2 1 FAD binding domain FAD_binding_2 PF00890.24 ACT01839.1 - 7.4e-05 22.0 0.3 0.001 18.2 0.8 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 ACT01839.1 - 0.0001 22.8 0.3 0.00025 21.5 0.2 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ACT01839.1 - 0.00029 20.2 0.1 0.00071 18.9 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ACT01839.1 - 0.0016 17.7 0.1 0.0025 17.1 0.1 1.2 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 ACT01839.1 - 0.0032 17.1 1.4 0.028 14.0 0.8 2.2 1 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ACT01839.1 - 0.009 14.8 0.0 0.034 12.8 0.1 1.8 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.22 ACT01839.1 - 0.011 14.9 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 ACT01839.1 - 0.027 13.8 0.2 0.038 13.3 0.2 1.4 1 1 0 1 1 1 0 FAD dependent oxidoreductase MFS_1 PF07690.16 ACT01840.1 - 2.1e-27 96.0 55.0 9.4e-16 57.7 30.1 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ACT01840.1 - 1.5e-08 33.7 0.3 1.5e-08 33.7 0.3 3.4 2 1 0 2 2 2 1 MFS/sugar transport protein Sugar_tr PF00083.24 ACT01840.1 - 6.7e-06 25.2 29.5 0.00066 18.7 8.4 2.5 1 1 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 ACT01840.1 - 0.0013 17.7 7.1 0.0055 15.6 5.2 2.1 1 1 0 2 2 2 1 MFS_1 like family TRI12 PF06609.13 ACT01840.1 - 0.0016 17.0 1.3 0.0016 17.0 1.3 2.2 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Folate_carrier PF01770.18 ACT01840.1 - 0.79 8.4 3.2 0.7 8.6 0.4 2.2 2 0 0 2 2 2 0 Reduced folate carrier HATPase_c PF02518.26 ACT01841.1 - 7.2e-19 68.3 0.1 1.1e-18 67.7 0.1 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT01841.1 - 1.3e-12 47.5 0.1 2.9e-12 46.4 0.1 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain 5TM-5TMR_LYT PF07694.12 ACT01841.1 - 1.4e-09 37.7 14.7 2.4e-09 37.0 14.7 1.3 1 0 0 1 1 1 1 5TMR of 5TMR-LYT HATPase_c_3 PF13589.6 ACT01841.1 - 0.0065 16.3 0.4 0.021 14.7 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2304 PF10066.9 ACT01841.1 - 0.017 15.4 6.0 0.017 15.4 6.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) HATPase_c_5 PF14501.6 ACT01841.1 - 0.035 14.0 0.7 0.063 13.2 0.1 1.7 2 0 0 2 2 2 0 GHKL domain HATPase_c_2 PF13581.6 ACT01841.1 - 0.074 13.0 0.0 0.15 12.0 0.0 1.5 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain Sec20 PF03908.13 ACT01841.1 - 1.1 9.3 4.8 0.48 10.4 0.2 2.6 3 1 0 3 3 3 0 Sec20 DUF1980 PF09323.10 ACT01841.1 - 9.7 6.1 13.4 0.98 9.3 2.6 2.9 2 1 0 3 3 3 0 Domain of unknown function (DUF1980) LPAM_1 PF08139.12 ACT01842.1 - 0.0015 18.9 3.0 0.0015 18.9 3.0 1.8 2 0 0 2 2 2 1 Prokaryotic membrane lipoprotein lipid attachment site DUF2880 PF11082.8 ACT01842.1 - 0.091 13.1 0.0 0.11 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2880) Melibiase_2 PF16499.5 ACT01843.1 - 1.1e-23 83.9 12.6 4.2e-16 58.9 7.4 3.0 2 2 2 4 4 4 2 Alpha galactosidase A CE2_N PF17996.1 ACT01843.1 - 2.4e-18 66.1 4.7 2.9e-05 24.0 0.1 3.6 4 0 0 4 4 4 3 Carbohydrate esterase 2 N-terminal Melibiase_C PF17801.1 ACT01843.1 - 1.1e-17 63.8 0.5 3.9e-17 62.1 0.5 2.0 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ACT01843.1 - 6.6e-05 22.0 0.1 0.00011 21.2 0.1 1.3 1 0 0 1 1 1 1 Melibiase Big_7 PF17957.1 ACT01843.1 - 0.2 12.5 23.2 0.98 10.2 2.0 5.0 5 0 0 5 5 5 0 Bacterial Ig domain Big_3_5 PF16640.5 ACT01843.1 - 0.81 9.9 25.7 0.74 10.0 2.5 4.5 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) DUF3244 PF11589.8 ACT01843.1 - 1.5 8.9 10.4 5.5 7.1 0.3 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3244) PAS_3 PF08447.12 ACT01844.1 - 1.8e-22 79.4 1.4 2.2e-10 40.7 0.8 2.7 2 1 0 2 2 2 2 PAS fold PAS_9 PF13426.7 ACT01844.1 - 3.4e-22 78.7 0.0 1.1e-09 38.5 0.0 2.8 2 0 0 2 2 2 2 PAS domain HATPase_c PF02518.26 ACT01844.1 - 2e-20 73.3 1.2 6.4e-20 71.7 1.2 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 ACT01844.1 - 7.2e-20 71.1 0.0 4e-12 46.1 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 ACT01844.1 - 2.9e-18 66.1 0.0 4.2e-11 43.1 0.0 3.2 3 1 0 3 3 3 2 PAS fold HisKA PF00512.25 ACT01844.1 - 2.2e-13 50.0 0.1 4.7e-13 49.0 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_11 PF14598.6 ACT01844.1 - 9.2e-06 25.8 0.0 7.5e-05 22.8 0.0 2.4 2 1 0 2 2 2 1 PAS domain PAS_8 PF13188.7 ACT01844.1 - 4.8e-05 23.3 0.0 0.00096 19.1 0.0 2.4 2 0 0 2 2 2 1 PAS domain HATPase_c_5 PF14501.6 ACT01844.1 - 0.00043 20.1 0.2 0.00087 19.2 0.2 1.5 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 ACT01844.1 - 0.0033 17.3 0.0 0.0081 16.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT01844.1 - 0.042 13.8 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Trehalase PF01204.18 ACT01844.1 - 0.047 12.5 0.0 0.074 11.9 0.0 1.2 1 0 0 1 1 1 0 Trehalase Pur_ac_phosph_N PF16656.5 ACT01845.1 - 3.3e-16 59.6 0.8 3.3e-16 59.6 0.8 2.3 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 ACT01845.1 - 3.6e-16 60.3 2.0 5.2e-16 59.8 1.5 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACT01845.1 - 0.00018 21.7 0.0 0.00042 20.5 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain YbjQ_1 PF01906.17 ACT01846.1 - 1.5e-38 131.6 5.4 1.6e-38 131.5 5.4 1.0 1 0 0 1 1 1 1 Putative heavy-metal-binding Methyltrans_RNA PF04452.14 ACT01846.1 - 0.022 14.1 0.0 0.027 13.8 0.0 1.1 1 0 0 1 1 1 0 RNA methyltransferase DUF4156 PF13698.6 ACT01846.1 - 0.024 14.9 0.1 0.031 14.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4156) Bombinin PF05298.11 ACT01846.1 - 0.057 13.1 0.1 0.07 12.8 0.1 1.2 1 0 0 1 1 1 0 Bombinin Spermine_synth PF01564.17 ACT01848.1 - 1.9e-07 30.7 0.0 2.6e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain HTH_18 PF12833.7 ACT01849.1 - 3.2e-23 81.8 0.9 5.8e-23 81.0 0.2 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01849.1 - 2.7e-20 71.9 0.4 5.9e-09 35.8 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT01849.1 - 1e-11 44.3 0.2 2e-11 43.5 0.2 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACT01849.1 - 1.6e-09 37.8 1.0 9.2e-09 35.3 1.0 2.3 1 1 0 1 1 1 1 AraC-like ligand binding domain AraC_binding_2 PF14525.6 ACT01849.1 - 0.0029 17.3 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 AraC-binding-like domain Cupin_3 PF05899.12 ACT01849.1 - 0.0039 16.8 0.0 0.0074 16.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) DMSP_lyase PF16867.5 ACT01849.1 - 0.01 15.5 0.7 0.051 13.2 0.4 2.1 2 0 0 2 2 2 1 Dimethlysulfonioproprionate lyase HTH_23 PF13384.6 ACT01849.1 - 0.047 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain TetR_N PF00440.23 ACT01849.1 - 0.15 11.9 0.1 0.27 11.0 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family PhyH PF05721.13 ACT01850.1 - 2.1e-28 100.1 0.0 2.6e-28 99.8 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Epimerase PF01370.21 ACT01851.1 - 3.6e-23 82.3 0.0 2.5e-21 76.3 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ACT01851.1 - 8.2e-07 28.4 0.0 7.4e-05 22.0 0.0 2.1 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 ACT01851.1 - 1.3e-06 28.1 0.0 0.00014 21.4 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ACT01851.1 - 1.5e-06 28.2 0.0 2.5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT01851.1 - 0.0023 17.5 0.0 0.032 13.8 0.0 2.1 1 1 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 ACT01851.1 - 0.0074 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein DUF1153 PF06627.11 ACT01851.1 - 0.12 12.5 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1153) FCD PF07729.12 ACT01852.1 - 5.9e-18 65.5 0.8 9.6e-18 64.8 0.8 1.3 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 ACT01852.1 - 1.5e-15 56.6 0.1 5.9e-15 54.7 0.0 2.1 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Fe_dep_repress PF01325.19 ACT01852.1 - 0.0017 18.5 0.1 0.011 15.9 0.0 2.5 2 1 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain Imm49 PF15575.6 ACT01852.1 - 0.02 14.7 0.9 0.028 14.2 0.9 1.2 1 0 0 1 1 1 0 Immunity protein 49 PaaX PF07848.12 ACT01852.1 - 0.078 13.2 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 PaaX-like protein HTH_24 PF13412.6 ACT01852.1 - 0.088 12.4 0.1 0.2 11.3 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding RPA_C PF08784.11 ACT01852.1 - 0.13 13.0 0.0 0.28 11.8 0.0 1.6 1 0 0 1 1 1 0 Replication protein A C terminal adh_short_C2 PF13561.6 ACT01853.1 - 3.4e-68 229.7 0.5 4.2e-68 229.4 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT01853.1 - 2e-58 197.1 1.4 2.4e-58 196.8 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT01853.1 - 6.5e-18 65.3 0.3 8.5e-18 64.9 0.3 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACT01853.1 - 0.00019 21.0 0.2 0.0003 20.3 0.1 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 ACT01853.1 - 0.00053 20.3 0.3 0.00098 19.4 0.3 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 ACT01853.1 - 0.0033 16.6 0.1 0.0058 15.8 0.1 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain Cas_Cas1 PF01867.16 ACT01853.1 - 0.0045 16.2 0.1 0.0059 15.8 0.1 1.1 1 0 0 1 1 1 1 CRISPR associated protein Cas1 THF_DHG_CYH_C PF02882.19 ACT01853.1 - 0.01 15.2 0.2 0.021 14.1 0.2 1.6 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 ACT01853.1 - 0.014 14.8 0.1 0.021 14.2 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Shikimate_DH PF01488.20 ACT01853.1 - 0.017 15.2 0.1 0.033 14.3 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase MR_MLE_C PF13378.6 ACT01854.1 - 4.6e-63 212.7 0.0 6.9e-63 212.2 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ACT01854.1 - 3e-18 66.1 0.0 5.6e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain YorP PF09629.10 ACT01854.1 - 0.022 15.0 0.1 6.5 7.0 0.0 2.8 2 1 1 3 3 3 0 YorP protein Amidohydro_2 PF04909.14 ACT01855.1 - 4.6e-36 125.1 0.5 5.2e-36 124.9 0.5 1.0 1 0 0 1 1 1 1 Amidohydrolase SAM_PNT PF02198.16 ACT01855.1 - 0.024 14.6 0.0 0.057 13.4 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain adh_short_C2 PF13561.6 ACT01856.1 - 1e-66 224.9 0.0 1.2e-66 224.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT01856.1 - 1.6e-61 207.2 0.1 2e-61 206.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT01856.1 - 2.6e-14 53.5 0.1 3.9e-14 53.0 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACT01856.1 - 0.001 18.6 0.3 0.0034 16.9 0.3 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 ACT01856.1 - 0.07 12.5 0.0 0.098 12.0 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) FAA_hydrolase PF01557.18 ACT01857.1 - 5.5e-72 242.0 0.0 6.9e-72 241.7 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family HxlR PF01638.17 ACT01858.1 - 5.5e-35 119.1 0.1 6.4e-35 118.9 0.1 1.0 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_5 PF01022.20 ACT01858.1 - 0.0001 22.1 0.0 0.00016 21.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family BLACT_WH PF17778.1 ACT01858.1 - 0.0043 17.0 0.9 0.11 12.5 0.1 2.5 1 1 1 2 2 2 1 Beta-lactamase associated winged helix domain HTH_20 PF12840.7 ACT01858.1 - 0.01 15.9 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain PadR PF03551.14 ACT01858.1 - 0.016 15.2 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family NAD_binding_10 PF13460.6 ACT01859.1 - 3.2e-20 72.8 0.0 9.2e-20 71.3 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT01859.1 - 2.2e-06 27.4 0.4 3.9e-06 26.6 0.4 1.4 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 ACT01859.1 - 0.00051 19.6 0.1 0.00091 18.8 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 ACT01859.1 - 0.11 12.9 0.1 0.19 12.2 0.1 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 ACT01859.1 - 0.16 12.1 0.4 0.33 11.1 0.4 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus DUF2269 PF10027.9 ACT01860.1 - 1.2e-14 54.6 10.8 1.5e-14 54.3 10.8 1.1 1 0 0 1 1 1 1 Predicted integral membrane protein (DUF2269) DUF1772 PF08592.11 ACT01860.1 - 0.015 15.6 1.0 0.023 15.0 1.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) UPF0093 PF03653.13 ACT01860.1 - 0.57 10.4 13.5 2.8 8.2 13.5 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0093) SirB PF04247.12 ACT01860.1 - 6.7 6.8 14.3 3.6 7.7 9.9 2.4 2 1 0 2 2 2 0 Invasion gene expression up-regulator, SirB Response_reg PF00072.24 ACT01861.1 - 1.7e-27 95.8 0.1 2.6e-27 95.2 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT01861.1 - 1.6e-22 79.4 0.0 3e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HTH_11 PF08279.12 ACT01861.1 - 0.012 15.5 1.2 0.31 11.0 0.0 3.1 3 0 0 3 3 3 0 HTH domain HATPase_c PF02518.26 ACT01862.1 - 8.9e-14 52.0 0.0 3.8e-13 49.9 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT01862.1 - 4.3e-08 33.4 0.1 7.9e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 HAMP domain HisKA PF00512.25 ACT01862.1 - 8.4e-07 28.9 0.1 1.5e-05 24.9 0.0 2.6 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain CpxA_peri PF16527.5 ACT01862.1 - 0.032 14.6 0.0 8.4 6.8 0.0 2.6 3 0 0 3 3 3 0 Two-component sensor protein CpxA, periplasmic domain HATPase_c_2 PF13581.6 ACT01862.1 - 0.036 14.0 0.0 2.2 8.2 0.0 2.4 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain DUF347 PF03988.12 ACT01862.1 - 5.8 7.2 7.9 28 5.0 2.1 2.5 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) VanZ PF04892.12 ACT01863.1 - 2.8e-26 92.6 8.5 4.7e-26 91.9 8.5 1.3 1 0 0 1 1 1 1 VanZ like family Peptidase_M48_N PF16491.5 ACT01863.1 - 0.067 13.1 0.4 0.067 13.1 0.4 2.8 2 1 1 3 3 3 0 CAAX prenyl protease N-terminal, five membrane helices Flavodoxin_2 PF02525.17 ACT01864.1 - 3.1e-42 144.5 0.0 3.5e-42 144.4 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ACT01864.1 - 0.00021 21.1 0.0 0.00026 20.8 0.0 1.4 1 0 0 1 1 1 1 NADPH-dependent FMN reductase SBP_bac_3 PF00497.20 ACT01865.1 - 6.6e-62 208.9 1.8 8.2e-62 208.6 1.8 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 ACT01865.1 - 7.2e-08 32.6 0.1 2.9e-07 30.7 0.1 2.0 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site Phosphonate-bd PF12974.7 ACT01865.1 - 4.1e-06 26.6 0.9 0.00026 20.7 0.9 2.6 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1 PF09084.11 ACT01865.1 - 0.0014 18.6 0.4 0.0097 15.9 0.3 2.1 1 1 1 2 2 2 2 NMT1/THI5 like BPD_transp_1 PF00528.22 ACT01866.1 - 3e-18 66.2 13.5 3e-18 66.2 13.5 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3377 PF11857.8 ACT01866.1 - 3.3 7.7 4.5 5.9 6.9 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) ABC_tran PF00005.27 ACT01867.1 - 1.3e-33 116.4 0.0 2.1e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01867.1 - 4.3e-16 59.6 0.0 3.5e-08 33.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT01867.1 - 3.1e-08 33.3 0.0 2e-07 30.7 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ACT01867.1 - 1.2e-05 25.3 0.0 0.14 11.8 0.1 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 ACT01867.1 - 6.6e-05 22.6 0.1 0.00012 21.7 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT01867.1 - 0.00019 21.8 0.7 0.00037 20.9 0.7 1.7 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ACT01867.1 - 0.00024 21.0 0.1 0.00044 20.2 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ACT01867.1 - 0.00045 20.5 0.8 0.0033 17.7 0.1 2.1 2 0 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 ACT01867.1 - 0.00085 18.2 0.3 1.9 7.2 0.1 2.9 2 1 0 2 2 2 2 Predicted ATPase of the ABC class AAA_23 PF13476.6 ACT01867.1 - 0.0015 19.1 0.0 0.0018 18.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ACT01867.1 - 0.0029 17.0 0.1 0.037 13.4 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_13 PF13166.6 ACT01867.1 - 0.0041 15.9 0.0 0.042 12.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ACT01867.1 - 0.0047 17.1 0.2 0.016 15.4 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ACT01867.1 - 0.0055 16.4 0.6 0.046 13.4 0.1 2.2 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ACT01867.1 - 0.009 15.8 0.3 0.024 14.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 ACT01867.1 - 0.0096 15.9 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain IstB_IS21 PF01695.17 ACT01867.1 - 0.01 15.6 0.1 0.34 10.6 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.6 ACT01867.1 - 0.021 14.4 0.1 0.094 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_PrkA PF08298.11 ACT01867.1 - 0.035 13.0 0.0 0.046 12.6 0.0 1.3 1 0 0 1 1 1 0 PrkA AAA domain SbcCD_C PF13558.6 ACT01867.1 - 0.049 13.9 2.0 0.43 10.8 0.2 3.1 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.6 ACT01867.1 - 0.052 13.8 0.0 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ACT01867.1 - 0.063 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 ACT01867.1 - 0.068 13.1 0.2 0.35 10.7 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea G-alpha PF00503.20 ACT01867.1 - 0.086 12.0 0.0 0.18 10.9 0.0 1.5 2 0 0 2 2 2 0 G-protein alpha subunit Adeno_IVa2 PF02456.15 ACT01867.1 - 0.11 11.3 0.1 0.23 10.2 0.1 1.5 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_14 PF13173.6 ACT01867.1 - 0.11 12.5 0.1 1.6 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ACT01867.1 - 0.14 12.2 0.3 0.34 10.9 0.1 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 ACT01867.1 - 0.43 10.9 2.0 1.6 9.1 0.2 2.2 2 1 1 3 3 3 0 AAA domain HD PF01966.22 ACT01868.1 - 2.9e-06 27.5 0.0 5.1e-06 26.7 0.0 1.5 1 1 0 1 1 1 1 HD domain HDOD PF08668.12 ACT01868.1 - 0.022 14.2 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 HDOD domain HTH_18 PF12833.7 ACT01869.1 - 1.4e-20 73.3 3.6 2.2e-20 72.7 0.4 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01869.1 - 1.2e-17 63.5 2.2 4.4e-10 39.4 0.5 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT01869.1 - 6e-08 32.7 0.1 2.2e-07 30.8 0.0 1.9 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT01869.1 - 1.7e-07 30.8 0.0 2.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Cupin domain HEAT_2 PF13646.6 ACT01870.1 - 2.9e-27 94.9 8.7 3.1e-11 43.5 0.8 3.4 2 1 0 3 3 3 3 HEAT repeats HEAT PF02985.22 ACT01870.1 - 2.8e-15 55.1 0.7 0.0008 19.5 0.0 5.9 6 0 0 6 6 6 4 HEAT repeat PhyH PF05721.13 ACT01870.1 - 9.1e-10 39.1 1.5 3e-09 37.5 1.4 1.9 1 1 1 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) HEAT_PBS PF03130.16 ACT01870.1 - 9.2e-10 38.3 11.7 0.027 15.1 0.0 6.7 6 0 0 6 6 6 2 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 ACT01870.1 - 5.3e-06 26.8 4.5 0.56 10.8 0.0 4.6 4 0 0 4 4 4 2 HEAT-like repeat Arm PF00514.23 ACT01870.1 - 0.00015 21.7 5.3 0.16 12.0 0.0 4.9 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 ACT01870.1 - 0.001 17.8 0.1 4.8 5.6 0.0 3.2 1 1 1 3 3 3 1 Adaptin N terminal region Cnd1 PF12717.7 ACT01870.1 - 0.038 14.1 0.0 13 5.8 0.0 2.5 1 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 YtkA PF13115.6 ACT01871.1 - 4.1e-13 49.8 0.0 5.4e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 YtkA-like FixH PF05751.11 ACT01871.1 - 0.048 13.7 0.2 0.27 11.3 0.0 1.9 2 0 0 2 2 2 0 FixH Gp_dh_C PF02800.20 ACT01872.1 - 1.3e-39 135.3 0.0 2e-39 134.7 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ACT01872.1 - 1.1e-22 80.2 0.0 2.8e-22 79.0 0.0 1.6 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 ACT01872.1 - 0.016 15.8 0.1 0.088 13.5 0.1 2.0 1 1 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 ACT01872.1 - 0.04 14.7 0.0 18 6.1 0.0 2.5 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.20 ACT01872.1 - 0.051 13.7 0.0 0.36 11.0 0.0 2.1 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ADH_zinc_N PF00107.26 ACT01872.1 - 0.086 12.8 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 3HCDH_N PF02737.18 ACT01872.1 - 0.16 11.9 0.0 1.9 8.3 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lipase_GDSL_2 PF13472.6 ACT01873.1 - 6.8e-25 88.5 0.3 8.2e-25 88.2 0.3 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ACT01873.1 - 9.5e-15 55.1 0.3 1.2e-14 54.8 0.3 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase GSCFA PF08885.11 ACT01873.1 - 0.07 12.8 0.0 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 GSCFA family ABC_tran PF00005.27 ACT01874.1 - 1e-30 107.0 0.0 1.6e-30 106.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01874.1 - 2.8e-12 47.1 0.1 1.1e-08 35.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ACT01874.1 - 0.0032 18.0 0.1 0.0059 17.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACT01874.1 - 0.0071 16.6 0.0 0.078 13.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.22 ACT01874.1 - 0.012 15.3 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_29 PF13555.6 ACT01874.1 - 0.029 14.1 0.0 0.072 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 ACT01874.1 - 0.044 13.5 0.0 0.1 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACT01874.1 - 0.14 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 ACT01874.1 - 0.18 11.4 0.0 3 7.4 0.0 2.1 1 1 0 2 2 2 0 AAA ATPase domain ABC2_membrane_2 PF12679.7 ACT01875.1 - 2.6e-26 92.6 14.0 4.2e-26 91.9 14.0 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 ACT01875.1 - 1.9e-13 50.8 27.7 2.1e-10 40.8 14.5 3.4 2 1 1 3 3 3 2 ABC-2 family transporter protein ABC2_membrane_5 PF13346.6 ACT01875.1 - 8.9e-05 22.1 3.4 8.9e-05 22.1 3.4 3.2 2 1 1 3 3 3 1 ABC-2 family transporter protein ABC2_membrane_3 PF12698.7 ACT01875.1 - 0.0002 20.6 21.3 0.0002 20.6 21.3 2.2 1 1 1 2 2 2 1 ABC-2 family transporter protein FA_desaturase PF00487.24 ACT01875.1 - 0.15 11.8 15.4 0.026 14.4 1.4 3.4 2 1 2 4 4 4 0 Fatty acid desaturase LAP1C PF05609.12 ACT01875.1 - 6.1 5.8 4.9 0.45 9.6 0.2 1.4 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) SseC PF04888.12 ACT01876.1 - 0.029 14.0 0.7 0.029 14.0 0.7 1.9 1 1 1 2 2 2 0 Secretion system effector C (SseC) like family DUF1398 PF07166.11 ACT01877.1 - 0.018 15.1 0.0 0.024 14.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1398) SgrR_N PF12793.7 ACT01878.1 - 0.012 15.8 0.3 0.013 15.7 0.3 1.0 1 0 0 1 1 1 0 Sugar transport-related sRNA regulator N-term Transcrip_reg PF01709.20 ACT01879.1 - 0.029 13.8 0.2 0.044 13.2 0.2 1.2 1 0 0 1 1 1 0 Transcriptional regulator Packaging_FI PF14000.6 ACT01879.1 - 0.079 13.4 0.1 0.095 13.2 0.1 1.1 1 0 0 1 1 1 0 DNA packaging protein FI DUF5063 PF16702.5 ACT01879.1 - 0.11 12.9 1.2 0.15 12.4 0.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5063) SNF2_N PF00176.23 ACT01881.1 - 1.7e-57 194.7 0.0 2.4e-57 194.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3670 PF12419.8 ACT01881.1 - 5e-38 130.1 1.4 1e-37 129.0 1.4 1.5 1 0 0 1 1 1 1 SNF2 Helicase protein Helicase_C PF00271.31 ACT01881.1 - 3.6e-17 62.7 0.0 7.5e-17 61.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT01881.1 - 0.0084 16.1 0.0 0.02 14.9 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 ACT01881.1 - 0.081 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Peptidase_M24 PF00557.24 ACT01882.1 - 1.2e-53 182.0 0.3 1.3e-53 181.8 0.3 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 TetR_N PF00440.23 ACT01883.1 - 2.8e-06 27.0 0.0 5.7e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Peripla_BP_2 PF01497.18 ACT01884.1 - 2.5e-24 86.2 0.1 3.2e-24 85.8 0.1 1.2 1 0 0 1 1 1 1 Periplasmic binding protein DUF3558 PF12079.8 ACT01884.1 - 0.99 9.4 5.5 1.4 8.8 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) HTH_18 PF12833.7 ACT01885.1 - 2e-20 72.9 0.0 5.3e-20 71.5 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT01885.1 - 2.9e-16 59.1 0.0 2.3e-10 40.3 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Peripla_BP_2 PF01497.18 ACT01885.1 - 2e-15 57.0 0.0 3.5e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein HTH_26 PF13443.6 ACT01885.1 - 0.057 13.9 0.0 6.9 7.2 0.0 2.8 3 0 0 3 3 3 0 Cro/C1-type HTH DNA-binding domain Pyr_redox_2 PF07992.14 ACT01886.1 - 9.4e-26 90.7 0.0 1.1e-25 90.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACT01886.1 - 1e-19 70.9 0.0 1.5e-15 57.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ACT01886.1 - 1.2e-08 34.1 0.3 4.8e-06 25.5 0.0 2.9 2 1 0 3 3 3 2 HI0933-like protein Pyr_redox PF00070.27 ACT01886.1 - 4.3e-08 33.6 0.4 9.1e-06 26.2 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ACT01886.1 - 3.6e-07 30.3 0.0 6.5e-06 26.3 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 ACT01886.1 - 5.3e-05 22.8 0.0 0.00013 21.5 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FMO-like PF00743.19 ACT01886.1 - 7.7e-05 21.3 0.0 0.00011 20.7 0.0 1.3 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Thi4 PF01946.17 ACT01886.1 - 0.00011 21.5 0.0 0.00075 18.8 0.0 2.0 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 ACT01886.1 - 0.00032 20.4 0.1 0.19 11.3 0.0 2.6 2 1 0 2 2 2 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 ACT01886.1 - 0.002 17.4 0.1 0.024 13.8 0.0 2.3 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 ACT01886.1 - 0.0067 15.5 0.0 0.13 11.3 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_7 PF13241.6 ACT01886.1 - 0.024 15.0 0.1 0.31 11.5 0.0 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding GIDA PF01134.22 ACT01886.1 - 0.027 13.6 0.0 0.047 12.8 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 ACT01886.1 - 0.052 13.5 0.0 8.9 6.3 0.0 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 ACT01886.1 - 0.093 12.0 0.0 0.31 10.2 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 ACT01886.1 - 0.1 11.7 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein GFO_IDH_MocA PF01408.22 ACT01887.1 - 6e-18 65.8 0.1 1.1e-17 64.9 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT01887.1 - 1.8e-07 31.2 0.0 1e-06 28.7 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACT01887.1 - 0.0014 19.2 0.3 0.0023 18.6 0.3 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 ACT01888.1 - 1.8e-28 99.8 1.0 5.2e-28 98.3 1.2 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT01888.1 - 8.2e-11 41.9 0.0 1.8e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 ACT01888.1 - 0.002 18.7 0.9 0.031 14.8 0.2 2.4 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Oxidoreduct_C PF16490.5 ACT01888.1 - 0.025 14.3 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain Sacchrp_dh_NADP PF03435.18 ACT01888.1 - 0.049 13.9 0.1 0.11 12.7 0.1 1.6 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_3 PF03447.16 ACT01888.1 - 0.085 13.5 0.1 0.15 12.7 0.1 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain PMSR PF01625.21 ACT01889.1 - 1.3e-57 194.2 0.4 3e-57 193.1 0.0 1.7 1 1 1 2 2 2 1 Peptide methionine sulfoxide reductase SelR PF01641.18 ACT01889.1 - 5.4e-34 116.9 0.0 9.5e-34 116.1 0.0 1.4 1 0 0 1 1 1 1 SelR domain Dopey_N PF04118.14 ACT01889.1 - 0.19 10.8 0.0 0.22 10.6 0.0 1.1 1 0 0 1 1 1 0 Dopey, N-terminal Dus PF01207.17 ACT01890.1 - 4.3e-45 154.1 0.0 5.4e-45 153.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Pyr_redox_2 PF07992.14 ACT01891.1 - 8.6e-55 186.0 0.1 1.2e-54 185.6 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ACT01891.1 - 5e-27 94.3 0.0 1.2e-26 93.1 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ACT01891.1 - 8.4e-25 87.1 0.4 2.7e-21 75.9 0.2 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACT01891.1 - 3.8e-11 42.8 0.0 1.7e-10 40.6 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ACT01891.1 - 1.6e-08 34.6 0.1 2.1e-05 24.5 0.0 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K_oxygenase PF13434.6 ACT01891.1 - 2.8e-07 30.0 0.0 0.00087 18.5 0.0 2.6 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 ACT01891.1 - 2.4e-06 27.7 0.1 0.026 14.7 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 ACT01891.1 - 5.7e-06 26.6 0.1 0.018 15.3 0.0 3.4 3 0 0 3 3 3 1 TrkA-N domain 2-Hacid_dh_C PF02826.19 ACT01891.1 - 1.2e-05 24.8 0.0 0.011 15.1 0.0 2.5 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 ACT01891.1 - 1.3e-05 24.6 0.0 0.019 14.2 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 ACT01891.1 - 1.9e-05 24.5 0.5 3.5 7.1 0.1 3.6 2 2 2 4 4 4 3 FAD dependent oxidoreductase XdhC_C PF13478.6 ACT01891.1 - 2e-05 25.1 0.0 0.077 13.5 0.0 2.4 2 0 0 2 2 2 2 XdhC Rossmann domain UDPG_MGDP_dh_N PF03721.14 ACT01891.1 - 4.9e-05 23.0 0.0 0.0054 16.3 0.0 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Thi4 PF01946.17 ACT01891.1 - 0.00013 21.3 0.2 0.0011 18.2 0.0 2.1 1 1 1 2 2 2 1 Thi4 family NAD_binding_7 PF13241.6 ACT01891.1 - 0.00027 21.3 0.0 0.42 11.1 0.0 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 ACT01891.1 - 0.00084 19.6 0.3 2.4 8.4 0.0 3.0 3 1 0 3 3 2 2 Saccharopine dehydrogenase NADP binding domain FAD_binding_2 PF00890.24 ACT01891.1 - 0.00091 18.4 0.5 0.062 12.4 0.0 2.9 3 1 0 4 4 4 1 FAD binding domain ApbA PF02558.16 ACT01891.1 - 0.0028 17.3 0.1 2.4 7.8 0.0 2.8 2 1 0 2 2 2 2 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 ACT01891.1 - 0.0054 15.8 0.1 2.6 7.0 0.0 3.1 2 2 1 3 3 3 1 Lycopene cyclase protein F420_oxidored PF03807.17 ACT01891.1 - 0.011 16.3 2.1 6.8 7.3 0.1 3.2 3 1 0 3 3 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ACT01891.1 - 0.017 15.3 0.0 2 8.6 0.0 2.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 ACT01891.1 - 0.02 14.2 0.0 0.055 12.8 0.0 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 ACT01891.1 - 0.029 13.5 4.4 1.9 7.5 0.1 4.1 3 1 2 5 5 5 0 Glucose inhibited division protein A DFP PF04127.15 ACT01891.1 - 0.057 13.3 0.1 11 5.8 0.0 2.7 2 1 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein HI0933_like PF03486.14 ACT01891.1 - 0.082 11.6 1.1 9.2 4.8 0.0 2.9 2 1 1 3 3 3 0 HI0933-like protein Shikimate_DH PF01488.20 ACT01891.1 - 0.1 12.7 0.0 1.9 8.6 0.0 2.5 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.23 ACT01891.1 - 0.12 12.4 0.5 12 5.8 0.0 2.8 2 1 1 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus LysR_substrate PF03466.20 ACT01892.1 - 1.2e-36 126.1 0.0 1.8e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01892.1 - 9.6e-23 79.9 0.4 2.1e-22 78.8 0.1 1.7 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family Amidohydro_3 PF07969.11 ACT01893.1 - 4.2e-21 76.0 0.7 6.1e-16 58.9 0.5 2.1 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 ACT01893.1 - 0.0011 18.3 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ACT01894.1 - 2.9e-18 66.6 1.2 2.1e-12 47.3 0.3 2.0 1 1 1 2 2 2 2 Amidohydrolase family Asp_Glu_race PF01177.22 ACT01895.1 - 9.7e-52 176.0 0.3 1.1e-51 175.8 0.3 1.0 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase HisKA_2 PF07568.12 ACT01895.1 - 0.033 14.3 0.0 0.08 13.0 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase Response_reg PF00072.24 ACT01896.1 - 1e-28 99.7 0.2 1.7e-28 99.0 0.2 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT01896.1 - 5e-22 77.8 0.3 1.1e-21 76.6 0.1 1.7 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal B12-binding PF02310.19 ACT01896.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 B12 binding domain Asp_Glu_race PF01177.22 ACT01897.1 - 1.7e-55 188.3 0.3 1.9e-55 188.1 0.3 1.0 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Lactamase_B_6 PF16661.5 ACT01897.1 - 0.12 11.8 0.1 0.43 10.0 0.2 1.8 1 1 1 2 2 2 0 Metallo-beta-lactamase superfamily domain Transglut_core PF01841.19 ACT01898.1 - 1.1e-07 32.3 0.5 2.8e-07 31.0 0.4 1.7 2 0 0 2 2 2 1 Transglutaminase-like superfamily DUF5011 PF16403.5 ACT01898.1 - 4e-07 30.1 3.2 9.1e-07 28.9 3.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5011) HYR PF02494.16 ACT01898.1 - 6.8e-05 23.1 0.5 0.00015 22.0 0.5 1.7 1 0 0 1 1 1 1 HYR domain DUF553 PF04473.12 ACT01898.1 - 0.003 17.1 0.3 2.4 7.7 0.2 2.7 1 1 1 2 2 2 2 Transglutaminase-like domain Big_3 PF07523.12 ACT01898.1 - 0.15 12.4 2.2 0.36 11.1 2.2 1.8 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 3) AMP-binding PF00501.28 ACT01899.1 - 8.6e-67 225.6 0.0 1.1e-66 225.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ACT01899.1 - 2.1e-07 31.8 0.0 5.4e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Creatinase_N PF01321.18 ACT01899.1 - 0.11 13.2 0.0 0.23 12.1 0.0 1.5 1 0 0 1 1 1 0 Creatinase/Prolidase N-terminal domain YabP PF07873.11 ACT01899.1 - 0.12 12.1 0.0 5.3 6.9 0.0 2.7 2 0 0 2 2 2 0 YabP family PP-binding PF00550.25 ACT01900.1 - 5e-06 26.8 0.3 1.9e-05 24.9 0.3 1.8 1 1 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 ACT01900.1 - 0.0037 17.5 0.3 0.0039 17.4 0.3 1.1 1 0 0 1 1 1 1 Acyl-carrier MBOAT PF03062.19 ACT01901.1 - 3.7e-14 52.9 10.5 3.7e-14 52.9 10.5 3.2 2 1 1 3 3 3 1 MBOAT, membrane-bound O-acyltransferase family Lipase_GDSL_2 PF13472.6 ACT01902.1 - 0.00021 21.7 0.4 0.0012 19.3 0.5 2.1 2 1 1 3 3 3 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ACT01902.1 - 0.04 13.9 0.5 0.12 12.3 0.4 1.9 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase LPAM_2 PF13627.6 ACT01903.1 - 0.023 14.5 1.2 0.036 13.9 1.2 1.3 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site DUF3558 PF12079.8 ACT01903.1 - 0.13 12.3 4.4 0.22 11.5 4.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) SpoOE-like PF09388.10 ACT01904.1 - 9.8e-13 47.8 0.6 1.1e-12 47.6 0.6 1.1 1 0 0 1 1 1 1 Spo0E like sporulation regulatory protein Antibiotic_NAT PF02522.14 ACT01905.1 - 5.6e-58 196.3 0.0 7e-58 196.0 0.0 1.0 1 0 0 1 1 1 1 Aminoglycoside 3-N-acetyltransferase NTP_transf_2 PF01909.23 ACT01906.1 - 0.00027 21.2 0.1 0.00062 20.0 0.1 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ACT01906.1 - 0.00062 19.8 0.2 0.0013 18.7 0.2 1.6 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Lactamase_B PF00753.27 ACT01907.1 - 4e-17 62.9 1.1 5.1e-17 62.5 1.1 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ACT01907.1 - 4.1e-06 26.4 0.1 5.5e-06 26.0 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 ACT01907.1 - 0.015 14.7 0.0 0.03 13.8 0.0 1.4 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain Lactamase_B_5 PF14597.6 ACT01907.1 - 0.021 14.3 0.0 0.03 13.8 0.0 1.3 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Peripla_BP_3 PF13377.6 ACT01908.1 - 4.5e-28 98.7 2.7 2.2e-26 93.2 0.1 2.4 3 0 0 3 3 3 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT01908.1 - 5e-18 65.5 0.0 6.5e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT01908.1 - 5.7e-16 58.0 0.1 1.7e-15 56.5 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACT01908.1 - 1.1e-15 57.9 0.0 2e-15 57.1 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_6 PF13458.6 ACT01908.1 - 0.00068 19.4 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein HTH_23 PF13384.6 ACT01908.1 - 0.0069 16.1 0.3 3.3 7.6 0.0 3.7 3 0 0 3 3 3 1 Homeodomain-like domain HTH_31 PF13560.6 ACT01908.1 - 0.048 14.0 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain SPOUT_MTase PF02590.17 ACT01908.1 - 0.056 13.4 0.0 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase HTH_10 PF04967.12 ACT01908.1 - 0.059 13.2 0.4 0.24 11.2 0.0 2.3 3 0 0 3 3 3 0 HTH DNA binding domain GntR PF00392.21 ACT01908.1 - 0.065 12.9 0.6 1.5 8.5 0.0 2.7 1 1 1 2 2 2 0 Bacterial regulatory proteins, gntR family Creatininase PF02633.14 ACT01908.1 - 0.11 11.9 0.1 1.2 8.5 0.0 2.1 1 1 1 2 2 2 0 Creatinine amidohydrolase HTH_18 PF12833.7 ACT01909.1 - 4.7e-21 74.9 0.1 5.9e-20 71.3 0.1 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain dCache_1 PF02743.18 ACT01909.1 - 1.3e-15 57.9 1.9 2.1e-15 57.2 1.9 1.3 1 0 0 1 1 1 1 Cache domain HTH_AraC PF00165.23 ACT01909.1 - 1.7e-11 43.9 0.0 4.3e-09 36.3 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT01909.1 - 4.4e-07 30.2 0.2 9.5e-07 29.1 0.2 1.6 1 0 0 1 1 1 1 GGDEF-like domain DUF4743 PF15916.5 ACT01909.1 - 0.00095 19.1 0.1 5.2 7.1 0.0 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4743) Ac76 PF05814.11 ACT01909.1 - 0.91 9.6 3.4 1.2 9.2 0.2 2.4 2 0 0 2 2 2 0 Orf76 (Ac76) BPD_transp_1 PF00528.22 ACT01910.1 - 2.2e-12 47.1 8.4 9.9e-12 45.0 8.4 1.9 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT01911.1 - 3.5e-14 53.0 12.1 3.5e-14 53.0 12.1 2.2 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACT01912.1 - 5.5e-16 59.2 3.1 1e-15 58.4 3.1 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT01912.1 - 6.9e-15 55.8 8.2 6.9e-15 55.8 8.2 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SHOCT PF09851.9 ACT01912.1 - 0.023 14.4 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 Short C-terminal domain LPAM_1 PF08139.12 ACT01912.1 - 1.5 9.5 4.8 3.7 8.2 4.8 1.8 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Sulfatase PF00884.23 ACT01913.1 - 3.1e-61 207.4 0.0 3.8e-61 207.2 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACT01913.1 - 6.6e-11 42.4 0.0 2.5e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 ACT01913.1 - 6.8e-11 42.4 0.0 1.4e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) DUF229 PF02995.17 ACT01913.1 - 6.4e-08 31.7 0.0 1.4e-07 30.6 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF229) DUF1501 PF07394.12 ACT01913.1 - 0.0047 16.0 0.0 0.0087 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) Metalloenzyme PF01676.18 ACT01913.1 - 0.097 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily Sulfatase PF00884.23 ACT01914.1 - 6e-62 209.8 0.0 8.2e-62 209.4 0.0 1.2 1 0 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 ACT01914.1 - 4.2e-14 52.7 0.1 8.7e-14 51.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 ACT01914.1 - 1.1e-08 35.1 0.3 3.6e-05 23.5 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 ACT01914.1 - 9.9e-07 27.7 0.0 1.4e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Metalloenzyme PF01676.18 ACT01914.1 - 0.0011 18.4 0.0 0.0019 17.6 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF1501 PF07394.12 ACT01914.1 - 0.055 12.5 0.0 0.076 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Ribosomal_L33 PF00471.20 ACT01915.1 - 5.7e-23 81.1 4.6 6.1e-23 81.0 4.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L33 Acetyltransf_2 PF00797.17 ACT01916.1 - 1.4e-62 211.6 0.0 1.7e-62 211.4 0.0 1.0 1 0 0 1 1 1 1 N-acetyltransferase Cupin_7 PF12973.7 ACT01917.1 - 1.3e-07 31.4 0.0 1.8e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 ChrR Cupin-like domain AraC_binding PF02311.19 ACT01917.1 - 6.5e-07 29.3 0.3 8.4e-07 29.0 0.3 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT01917.1 - 2.5e-06 27.1 0.4 6.2e-06 25.8 0.2 1.7 1 1 1 2 2 2 1 Cupin domain Vsr PF03852.15 ACT01917.1 - 0.087 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 DNA mismatch endonuclease Vsr Ank_2 PF12796.7 ACT01918.1 - 3.3e-28 98.1 0.0 2.1e-09 37.9 0.1 5.4 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ACT01918.1 - 2.4e-20 72.6 3.7 4.5e-07 30.3 0.0 7.2 5 3 3 8 8 8 4 Ankyrin repeats (many copies) Ank PF00023.30 ACT01918.1 - 6.4e-17 61.2 3.5 0.00024 21.4 0.0 6.7 6 1 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 ACT01918.1 - 1.8e-16 60.0 3.0 3.5e-06 27.2 0.0 6.5 5 2 1 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ACT01918.1 - 2.3e-14 52.1 6.3 0.00026 21.2 0.0 7.9 8 1 1 9 9 9 3 Ankyrin repeat 3-dmu-9_3-mt PF06983.13 ACT01919.1 - 3.9e-12 46.7 0.0 5.3e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase Glyoxalase PF00903.25 ACT01919.1 - 1.5e-07 31.7 0.0 2.3e-07 31.1 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ACT01919.1 - 0.033 15.0 0.1 0.048 14.5 0.1 1.3 1 0 0 1 1 1 0 Glyoxalase-like domain PCMT PF01135.19 ACT01919.1 - 0.099 12.4 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPR_7 PF13176.6 ACT01919.1 - 0.11 12.6 0.1 2.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ACT01919.1 - 3.2 8.2 5.1 11 6.5 0.4 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat FBPase_2 PF06874.11 ACT01920.1 - 5.1e-281 933.6 11.1 6.2e-281 933.3 11.1 1.0 1 0 0 1 1 1 1 Firmicute fructose-1,6-bisphosphatase Metallophos PF00149.28 ACT01920.1 - 0.00015 22.4 0.6 0.75 10.2 0.0 2.8 3 0 0 3 3 3 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACT01920.1 - 0.031 14.5 0.1 1.4 9.0 0.0 2.5 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain Glyco_transf_36 PF06165.11 ACT01921.1 - 4.4e-152 504.6 0.0 7.7e-76 254.8 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase family 36 Glyco_hydro_36 PF17167.4 ACT01921.1 - 1.3e-118 396.4 0.7 1.8e-118 395.9 0.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain Glycoamylase PF10091.9 ACT01921.1 - 1.9e-13 50.5 0.6 1.9e-13 50.5 0.6 1.8 2 0 0 2 2 2 1 Putative glucoamylase Glyco_trans_2_3 PF13632.6 ACT01921.1 - 0.0056 16.6 1.0 0.0056 16.6 1.0 3.6 5 0 0 5 5 5 1 Glycosyl transferase family group 2 DUF3131 PF11329.8 ACT01921.1 - 0.079 12.0 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3131) Bac_luciferase PF00296.20 ACT01924.1 - 7.6e-48 163.5 0.0 9.1e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase MarR PF01047.22 ACT01925.1 - 5.1e-16 58.3 0.0 8.9e-16 57.6 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT01925.1 - 4.2e-09 36.8 0.0 8e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR_2 PF12802.7 ACT01925.1 - 4.9e-09 35.9 0.0 7.8e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 ACT01925.1 - 6.8e-06 25.9 0.1 1.5e-05 24.8 0.0 1.6 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.6 ACT01925.1 - 2.5e-05 24.4 0.0 4.4e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.6 ACT01925.1 - 0.0001 21.8 0.2 0.00034 20.1 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding B-block_TFIIIC PF04182.12 ACT01925.1 - 0.00061 19.9 0.0 0.0011 19.0 0.0 1.6 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC HTH_20 PF12840.7 ACT01925.1 - 0.0075 16.3 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4423 PF14394.6 ACT01925.1 - 0.013 15.2 0.0 0.43 10.3 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4423) HxlR PF01638.17 ACT01925.1 - 0.014 15.2 0.0 0.027 14.3 0.0 1.5 1 0 0 1 1 1 0 HxlR-like helix-turn-helix DUF2250 PF10007.9 ACT01925.1 - 0.015 15.4 0.0 0.064 13.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) PadR PF03551.14 ACT01925.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family MFS_1 PF07690.16 ACT01926.1 - 3e-43 148.1 45.9 3e-43 148.1 45.9 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01926.1 - 2.8e-07 29.8 7.8 2.8e-07 29.8 7.8 2.3 2 1 1 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.14 ACT01926.1 - 1.2e-05 24.8 7.3 1.2e-05 24.8 7.3 2.8 1 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 ACT01926.1 - 2.6 6.2 22.0 0.041 12.2 2.2 3.8 2 2 2 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family LysR_substrate PF03466.20 ACT01927.1 - 3.8e-35 121.2 0.0 5.2e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT01927.1 - 8.6e-19 67.2 0.0 2.1e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family TPR_16 PF13432.6 ACT01928.1 - 5.5e-13 49.3 4.3 9.7e-05 22.9 0.2 3.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ACT01928.1 - 9.3e-13 47.2 9.3 0.00029 20.7 0.0 5.7 4 1 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ACT01928.1 - 2.3e-10 39.9 3.9 0.0027 17.8 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ACT01928.1 - 2.4e-09 37.2 4.5 0.016 16.0 0.1 4.7 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 ACT01928.1 - 5.7e-09 36.3 2.5 7.1e-06 26.4 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ACT01928.1 - 8.3e-09 35.6 4.2 3.7e-06 27.1 0.0 3.4 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ACT01928.1 - 2.9e-08 33.5 4.3 0.089 13.2 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ACT01928.1 - 9.5e-08 32.0 6.6 0.067 13.3 0.7 4.4 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 ACT01928.1 - 9.8e-06 25.2 10.7 0.023 14.5 0.0 4.6 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 ACT01928.1 - 2.7e-05 23.5 1.7 0.24 10.6 0.1 3.3 1 1 1 3 3 3 2 Tetratricopeptide repeat DUF4192 PF13830.6 ACT01928.1 - 0.00034 20.8 0.2 0.017 15.2 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4192) TAtT PF16811.5 ACT01928.1 - 0.00047 19.5 0.3 0.01 15.1 0.1 2.1 2 0 0 2 2 2 1 TRAP transporter T-component TPR_11 PF13414.6 ACT01928.1 - 0.0019 17.8 5.6 1.7 8.4 0.2 4.8 4 1 1 5 5 5 1 TPR repeat TPR_MalT PF17874.1 ACT01928.1 - 0.0035 16.7 0.1 0.0084 15.5 0.0 1.6 1 1 0 1 1 1 1 MalT-like TPR region TPR_12 PF13424.6 ACT01928.1 - 0.0078 16.5 2.6 0.1 12.9 0.0 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.8 ACT01928.1 - 0.0095 14.9 2.8 0.047 12.6 0.0 2.5 3 0 0 3 3 3 1 NMDA receptor-regulated protein 1 DUF4919 PF16266.5 ACT01928.1 - 0.035 14.1 0.2 2.1 8.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4919) TPR_4 PF07721.14 ACT01928.1 - 0.038 14.6 0.0 23 6.0 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 ACT01928.1 - 0.09 12.9 0.6 0.87 9.8 0.5 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat AAA PF00004.29 ACT01929.1 - 8.9e-44 149.1 0.0 1.5e-43 148.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ACT01929.1 - 1.4e-09 37.6 0.0 2.8e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 ACT01929.1 - 1.3e-06 28.7 0.2 0.00097 19.4 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ACT01929.1 - 1.8e-06 28.4 0.6 0.0012 19.2 0.0 2.6 1 1 1 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 ACT01929.1 - 1e-05 25.6 0.0 7.1e-05 22.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ACT01929.1 - 1.8e-05 24.7 0.0 4.4e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ACT01929.1 - 5e-05 23.1 0.0 0.00014 21.7 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ACT01929.1 - 0.00014 22.0 0.0 0.0044 17.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ACT01929.1 - 0.00032 20.7 0.0 1.1 9.2 0.0 2.6 1 1 1 2 2 2 2 ATPase domain predominantly from Archaea AAA_25 PF13481.6 ACT01929.1 - 0.00087 18.9 0.1 0.027 14.1 0.1 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ACT01929.1 - 0.0013 19.1 0.0 0.0026 18.1 0.0 1.5 1 0 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 ACT01929.1 - 0.0018 18.8 0.0 0.0038 17.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter Mg_chelatase PF01078.21 ACT01929.1 - 0.0021 17.5 0.0 0.0039 16.6 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ACT01929.1 - 0.0026 17.0 0.0 0.0041 16.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 ACT01929.1 - 0.0026 17.5 0.0 0.0053 16.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 ACT01929.1 - 0.0032 17.6 0.0 0.0073 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 ACT01929.1 - 0.0045 16.5 0.0 0.0093 15.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 ACT01929.1 - 0.0096 15.2 0.1 0.023 14.0 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 ACT01929.1 - 0.019 14.9 0.0 0.5 10.3 0.0 2.4 1 1 1 2 2 2 0 NACHT domain AAA_18 PF13238.6 ACT01929.1 - 0.021 15.4 0.0 0.054 14.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 ACT01929.1 - 0.025 14.3 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ATP-synt_ab PF00006.25 ACT01929.1 - 0.026 14.2 0.0 0.05 13.3 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain TsaE PF02367.17 ACT01929.1 - 0.05 13.6 0.0 0.41 10.6 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 ACT01929.1 - 0.06 13.1 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ACT01929.1 - 0.073 13.3 0.1 0.44 10.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 ACT01929.1 - 0.081 12.1 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_3 PF07726.11 ACT01929.1 - 0.089 12.7 0.0 0.23 11.3 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 ACT01929.1 - 0.096 13.1 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 ACT01929.1 - 0.12 12.3 0.1 0.68 9.8 0.1 2.0 1 1 0 1 1 1 0 Rad17 P-loop domain Beta_elim_lyase PF01212.21 ACT01930.1 - 2.2e-30 105.9 0.0 2.8e-30 105.6 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ACT01930.1 - 9.7e-05 21.8 0.0 0.00026 20.4 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 ACT01930.1 - 0.00074 18.8 0.0 0.00083 18.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Sipho_Gp157 PF05565.11 ACT01930.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Siphovirus Gp157 adh_short PF00106.25 ACT01931.1 - 5.6e-37 127.1 0.0 6.8e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT01931.1 - 8.8e-30 104.0 0.0 1.1e-29 103.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT01931.1 - 2.3e-06 27.6 0.1 4.4e-06 26.7 0.0 1.5 1 1 0 1 1 1 1 KR domain 4HBT PF03061.22 ACT01933.1 - 4.2e-18 65.5 0.0 6.3e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 ACT01933.1 - 0.043 14.3 0.1 0.049 14.1 0.1 1.3 1 0 0 1 1 1 0 Thioesterase-like superfamily IU_nuc_hydro PF01156.19 ACT01934.1 - 2.8e-81 273.4 0.1 3.4e-81 273.1 0.1 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Peptidase_S11 PF00768.20 ACT01935.1 - 1.9e-58 197.8 0.1 2.7e-58 197.2 0.1 1.2 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 ACT01935.1 - 7.7e-09 35.4 0.1 1.3e-08 34.7 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase enzyme family Peptidase_S13 PF02113.15 ACT01935.1 - 1.8e-08 33.6 0.1 0.0038 16.0 0.1 2.1 1 1 1 2 2 2 2 D-Ala-D-Ala carboxypeptidase 3 (S13) family Hydrolase_3 PF08282.12 ACT01936.1 - 7.3e-41 140.6 0.0 8.5e-41 140.4 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ACT01936.1 - 5.5e-09 35.9 0.0 0.00019 21.1 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 ACT01936.1 - 3.2e-05 24.3 0.1 0.0011 19.3 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT01936.1 - 0.012 16.1 0.0 6.5 7.1 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase YdjM PF04307.14 ACT01938.1 - 8.4e-25 87.0 13.3 3.5e-24 85.1 13.3 2.0 1 1 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase Porin_5 PF16930.5 ACT01938.1 - 0.25 9.8 0.0 0.35 9.3 0.0 1.1 1 0 0 1 1 1 0 Putative porin NigD_N PF12667.7 ACT01939.1 - 0.023 14.8 0.1 0.22 11.7 0.0 2.1 2 0 0 2 2 2 0 NigD-like N-terminal OB domain Metallophos PF00149.28 ACT01941.1 - 1.5e-10 41.9 0.3 5.3e-10 40.1 0.3 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACT01941.1 - 6e-09 36.3 0.3 8.8e-09 35.8 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DLH PF01738.18 ACT01941.1 - 0.038 13.5 0.0 0.071 12.7 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Metallophos_2 PF12850.7 ACT01942.1 - 2.1e-31 109.4 0.0 2.3e-31 109.2 0.0 1.0 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 ACT01942.1 - 8.8e-09 36.2 0.0 5.1e-05 23.9 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase HTH_5 PF01022.20 ACT01943.1 - 9.7e-17 60.6 0.2 1.6e-16 59.9 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACT01943.1 - 4e-10 39.6 0.1 5.7e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 ACT01943.1 - 0.0034 17.2 0.3 0.0077 16.1 0.3 1.7 1 1 0 1 1 1 1 MarR family Arg_repressor PF01316.21 ACT01943.1 - 0.045 13.5 0.6 0.099 12.4 0.6 1.7 1 1 0 1 1 1 0 Arginine repressor, DNA binding domain HTH_1 PF00126.27 ACT01943.1 - 0.085 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family HxlR PF01638.17 ACT01943.1 - 0.12 12.2 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 HxlR-like helix-turn-helix ThuA PF06283.11 ACT01944.1 - 3.2e-14 53.6 0.0 3.8e-14 53.4 0.0 1.0 1 0 0 1 1 1 1 Trehalose utilisation Glyoxalase_4 PF13669.6 ACT01945.1 - 5.7e-24 84.5 0.0 7.1e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Fmp27_SW PF10305.9 ACT01945.1 - 0.11 13.2 0.0 0.16 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain A_deaminase PF00962.22 ACT01946.1 - 3.6e-82 276.3 0.0 4e-82 276.2 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 ACT01946.1 - 2.6e-08 33.6 0.4 1.5e-07 31.1 0.4 2.2 1 1 0 1 1 1 1 Amidohydrolase family TatD_DNase PF01026.21 ACT01946.1 - 0.12 11.7 0.8 4.7 6.5 0.0 3.0 3 1 0 3 3 3 0 TatD related DNase Amidohydro_2 PF04909.14 ACT01946.1 - 0.17 11.7 0.1 0.35 10.6 0.1 1.5 1 0 0 1 1 1 0 Amidohydrolase Aminotran_5 PF00266.19 ACT01947.1 - 7.2e-34 117.3 0.0 2.8e-33 115.4 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ACT01947.1 - 0.00084 18.0 0.0 0.0019 16.8 0.0 1.5 1 1 1 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ACT01947.1 - 0.017 14.4 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Peptidase_M20 PF01546.28 ACT01948.1 - 1.6e-32 112.9 0.1 2.4e-32 112.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 ACT01948.1 - 8.2e-07 28.9 0.0 1.2e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 M20_dimer PF07687.14 ACT01948.1 - 0.00014 21.8 0.0 0.00028 20.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.14 ACT01948.1 - 0.0073 15.4 0.0 0.09 11.8 0.0 2.3 3 0 0 3 3 3 1 M42 glutamyl aminopeptidase Amidohydro_1 PF01979.20 ACT01949.1 - 1.3e-28 100.4 0.0 1.6e-28 100.0 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ACT01949.1 - 2.1e-15 57.2 0.7 1.1e-07 31.7 0.0 2.7 2 1 0 2 2 2 2 Amidohydrolase family DHOase PF12890.7 ACT01949.1 - 0.0016 18.4 0.0 0.022 14.7 0.0 2.1 2 0 0 2 2 2 1 Dihydro-orotase-like Amidohydro_2 PF04909.14 ACT01949.1 - 0.016 15.0 0.1 0.22 11.3 0.1 2.2 1 1 0 1 1 1 0 Amidohydrolase Transthyretin PF00576.21 ACT01950.1 - 3.4e-32 111.4 0.0 3.8e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family Uricase PF01014.18 ACT01951.1 - 1e-29 103.4 0.0 1.6e-14 54.3 0.0 2.2 2 0 0 2 2 2 2 Uricase OHCU_decarbox PF09349.10 ACT01952.1 - 1.2e-42 146.1 0.0 1.3e-42 145.9 0.0 1.0 1 0 0 1 1 1 1 OHCU decarboxylase Fer2_2 PF01799.20 ACT01953.1 - 3.9e-30 103.7 0.0 3.9e-30 103.7 0.0 1.6 2 0 0 2 2 2 1 [2Fe-2S] binding domain Fer2 PF00111.27 ACT01953.1 - 1.1e-05 25.3 1.3 1.1e-05 25.3 1.3 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer2_3 PF13085.6 ACT01953.1 - 0.00057 19.9 0.3 0.0012 18.9 0.3 1.6 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2_4 PF13510.6 ACT01953.1 - 0.021 14.9 2.0 0.042 13.9 1.9 1.6 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Ald_Xan_dh_C2 PF02738.18 ACT01954.1 - 5.7e-147 490.5 0.0 7.3e-147 490.1 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Ald_Xan_dh_C PF01315.22 ACT01954.1 - 9.7e-33 112.8 0.1 1.9e-32 111.9 0.1 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain FAD_binding_5 PF00941.21 ACT01955.1 - 3.3e-28 98.5 0.0 6.9e-28 97.5 0.0 1.4 2 0 0 2 2 2 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 ACT01955.1 - 1.4e-17 63.7 0.0 2.8e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain BPD_transp_2 PF02653.16 ACT01956.1 - 1e-31 110.1 31.5 1.3e-31 109.8 31.5 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component DUF2981 PF11200.8 ACT01956.1 - 1.7 8.3 3.1 2.4 7.8 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) BPD_transp_2 PF02653.16 ACT01957.1 - 4.8e-47 160.4 29.9 4.8e-47 160.4 29.9 1.8 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component Dexa_ind PF15198.6 ACT01957.1 - 0.55 10.4 0.1 0.55 10.4 0.1 2.3 3 0 0 3 3 3 0 Dexamethasone-induced ABC_tran PF00005.27 ACT01958.1 - 1.5e-46 158.3 0.0 1.5e-31 109.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACT01958.1 - 7.8e-06 25.9 0.1 0.0069 16.2 0.0 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_27 PF13514.6 ACT01958.1 - 0.0016 18.1 0.0 0.0039 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT01958.1 - 0.0026 17.4 0.1 0.012 15.3 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACT01958.1 - 0.0087 16.6 0.0 0.018 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 ACT01958.1 - 0.022 14.2 0.0 1.9 7.9 0.0 2.5 2 1 1 3 3 3 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ACT01958.1 - 0.057 13.3 0.4 0.32 10.9 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 ACT01958.1 - 0.13 12.1 0.0 7.7 6.4 0.1 2.8 3 0 0 3 3 3 0 NACHT domain PKS_DE PF18369.1 ACT01958.1 - 0.14 12.8 0.0 0.36 11.4 0.0 1.7 1 0 0 1 1 1 0 Polyketide synthase dimerisation element domain AAA_15 PF13175.6 ACT01958.1 - 0.24 11.1 0.0 4.5 6.9 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain IstB_IS21 PF01695.17 ACT01958.1 - 0.26 11.0 1.1 8.7 6.0 0.0 2.7 3 0 0 3 3 3 0 IstB-like ATP binding protein Bmp PF02608.14 ACT01959.1 - 4e-56 190.2 0.0 5.1e-56 189.9 0.0 1.1 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like NTP_transf_3 PF12804.7 ACT01960.1 - 1.5e-14 54.7 0.0 2.6e-14 53.9 0.0 1.3 2 0 0 2 2 2 1 MobA-like NTP transferase domain XdhC_C PF13478.6 ACT01961.1 - 2.1e-23 83.2 0.0 4e-23 82.3 0.0 1.5 1 1 0 1 1 1 1 XdhC Rossmann domain XdhC_CoxI PF02625.16 ACT01961.1 - 2.4e-17 62.9 0.2 1.1e-16 60.7 0.0 2.1 2 0 0 2 2 2 1 XdhC and CoxI family Amidohydro_1 PF01979.20 ACT01962.1 - 9.6e-78 261.9 0.0 1.1e-77 261.7 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ACT01962.1 - 2.6e-19 70.0 0.1 3.2e-12 46.7 0.0 2.2 1 1 1 2 2 2 2 Amidohydrolase family PucR PF07905.11 ACT01963.1 - 2e-32 111.9 0.0 1.1e-30 106.3 0.0 2.5 2 0 0 2 2 2 1 Purine catabolism regulatory protein-like family HTH_30 PF13556.6 ACT01963.1 - 3.9e-21 74.6 0.2 9.4e-21 73.4 0.2 1.7 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain GGDEF_2 PF17853.1 ACT01963.1 - 0.0008 19.6 0.1 0.0021 18.3 0.1 1.7 1 0 0 1 1 1 1 GGDEF-like domain DUF2089 PF09862.9 ACT01963.1 - 0.016 15.2 0.1 0.039 14.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) HTH_1 PF00126.27 ACT01963.1 - 0.019 14.9 0.0 0.072 13.1 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family Cu_amine_oxidN1 PF07833.11 ACT01964.1 - 2.2e-12 47.3 0.6 1.5e-10 41.4 0.0 3.5 3 0 0 3 3 3 1 Copper amine oxidase N-terminal domain Beta-lactamase PF00144.24 ACT01965.1 - 1.1e-27 97.2 0.1 3.5e-27 95.5 0.1 1.7 1 1 0 1 1 1 1 Beta-lactamase MFS_1 PF07690.16 ACT01966.1 - 1.3e-53 182.2 49.3 2.3e-53 181.4 47.3 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT01966.1 - 9.6e-18 64.3 40.6 9.6e-11 41.2 14.0 2.7 2 2 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 ACT01966.1 - 3.3e-08 32.4 18.8 3.3e-08 32.4 18.8 1.8 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 ACT01966.1 - 9.8e-07 27.7 40.3 0.0022 16.6 4.7 3.2 1 1 1 2 2 2 2 MFS/sugar transport protein SNARE_assoc PF09335.11 ACT01967.1 - 9.7e-18 64.8 6.8 9.7e-18 64.8 6.8 2.3 3 0 0 3 3 3 1 SNARE associated Golgi protein DUF2232 PF09991.9 ACT01967.1 - 0.0063 15.7 2.2 0.0063 15.7 2.2 2.2 2 2 0 2 2 2 1 Predicted membrane protein (DUF2232) RseC_MucC PF04246.12 ACT01967.1 - 0.13 12.3 0.3 0.13 12.3 0.3 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC FSAP_sig_propep PF03032.15 ACT01967.1 - 1.5 8.9 3.1 2 8.5 0.8 2.1 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide DPM3 PF08285.11 ACT01967.1 - 2.5 8.3 5.6 0.63 10.3 0.2 2.3 2 1 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) BacA PF02673.18 ACT01970.1 - 1.8e-82 276.9 17.6 2.1e-82 276.7 17.6 1.0 1 0 0 1 1 1 1 Bacitracin resistance protein BacA DUF5058 PF16481.5 ACT01970.1 - 0.00047 19.9 5.6 0.14 11.8 1.4 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF5058) LapA_dom PF06305.11 ACT01970.1 - 0.75 9.7 13.9 16 5.4 0.0 4.1 3 1 1 4 4 4 0 Lipopolysaccharide assembly protein A domain DUF21 PF01595.20 ACT01971.1 - 9.4e-49 165.5 2.3 1.6e-48 164.8 2.3 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CorC_HlyC PF03471.17 ACT01971.1 - 1.6e-13 50.4 0.1 3.7e-13 49.3 0.1 1.6 1 0 0 1 1 1 1 Transporter associated domain CBS PF00571.28 ACT01971.1 - 3.5e-09 37.0 0.7 1.1e-05 25.8 0.2 2.6 2 0 0 2 2 2 2 CBS domain Lin0512_fam PF09585.10 ACT01972.1 - 4.5e-45 152.4 0.4 5e-45 152.2 0.4 1.0 1 0 0 1 1 1 1 Conserved hypothetical protein (Lin0512_fam) TcA_RBD PF18518.1 ACT01972.1 - 0.14 12.5 0.0 0.17 12.2 0.0 1.2 1 0 0 1 1 1 0 TcA receptor binding domain DUF3900 PF13039.6 ACT01973.1 - 4.2e-131 436.4 1.0 5e-131 436.2 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3900) DUF3898 PF13037.6 ACT01973.1 - 5.9e-37 125.6 0.0 1.1e-36 124.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3898) NO_synthase PF02898.15 ACT01974.1 - 3.5e-170 565.9 0.0 4e-170 565.7 0.0 1.0 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain VARLMGL PF14383.6 ACT01974.1 - 0.17 11.4 2.4 0.31 10.6 2.4 1.4 1 0 0 1 1 1 0 DUF761-associated sequence motif DsbB PF02600.16 ACT01975.1 - 2.6e-10 40.9 9.5 3.6e-09 37.2 9.5 2.1 1 1 0 1 1 1 1 Disulfide bond formation protein DsbB InaF-motif PF15018.6 ACT01975.1 - 0.005 16.7 0.2 0.012 15.5 0.2 1.7 1 0 0 1 1 1 1 TRP-interacting helix Thioredoxin_4 PF13462.6 ACT01976.1 - 2.3e-36 125.5 0.3 3e-36 125.1 0.3 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 ACT01976.1 - 6.6e-12 45.6 2.3 2.9e-10 40.3 0.1 2.1 1 1 0 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_5 PF13743.6 ACT01976.1 - 9.1e-05 22.2 0.1 0.00016 21.4 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin DUF929 PF06053.11 ACT01976.1 - 0.0013 18.1 0.8 0.0027 17.1 0.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF929) Thioredoxin_3 PF13192.6 ACT01976.1 - 0.016 15.3 0.2 0.42 10.7 0.0 2.7 3 0 0 3 3 3 0 Thioredoxin domain Thioredoxin_2 PF13098.6 ACT01976.1 - 0.077 13.4 4.8 0.41 11.1 4.8 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain ETRAMP PF09716.10 ACT01976.1 - 0.43 10.7 3.5 0.79 9.8 0.7 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) ABC2_membrane_3 PF12698.7 ACT01976.1 - 1.9 7.5 4.6 6.2 5.8 4.6 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF1294 PF06961.13 ACT01977.1 - 4.8e-24 84.3 1.5 4.8e-24 84.3 1.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1294) TauE PF01925.19 ACT01977.1 - 0.002 17.8 1.4 0.0025 17.5 1.4 1.2 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE HrpB_C PF08482.10 ACT01978.1 - 3.9e-55 185.9 0.2 8.8e-55 184.7 0.2 1.7 1 0 0 1 1 1 1 ATP-dependent helicase C-terminal Helicase_C PF00271.31 ACT01978.1 - 1.1e-13 51.5 0.0 3e-13 50.1 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 ACT01978.1 - 3.5e-13 49.8 0.1 7e-13 48.8 0.1 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 ACT01978.1 - 6.3e-08 32.6 0.0 1.1e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 ACT01978.1 - 0.011 15.7 0.0 0.031 14.2 0.0 1.7 2 0 0 2 2 2 0 Flavivirus DEAD domain AAA_19 PF13245.6 ACT01978.1 - 0.089 13.1 0.2 0.22 11.9 0.1 1.6 2 0 0 2 2 2 0 AAA domain NAGPA PF09992.9 ACT01979.1 - 0.00019 21.6 0.1 0.00029 21.1 0.1 1.2 1 0 0 1 1 1 1 Phosphodiester glycosidase CorA PF01544.18 ACT01980.1 - 1.5e-72 244.4 2.0 1.7e-72 244.2 2.0 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein CBF PF03914.17 ACT01980.1 - 0.0085 16.1 0.1 0.016 15.3 0.1 1.4 1 0 0 1 1 1 1 CBF/Mak21 family tRNA-synt_1c PF00749.21 ACT01981.1 - 1.3e-61 208.3 0.0 1.4e-61 208.1 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain CbiZ PF01955.18 ACT01982.1 - 2.4e-51 174.6 7.1 2.9e-51 174.3 7.1 1.0 1 0 0 1 1 1 1 Adenosylcobinamide amidohydrolase Aminotran_1_2 PF00155.21 ACT01983.1 - 5e-30 104.9 0.0 5.6e-30 104.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 ACT01983.1 - 0.0012 17.8 0.0 0.0027 16.7 0.0 1.4 1 1 0 1 1 1 1 Allinase Cys_Met_Meta_PP PF01053.20 ACT01983.1 - 0.031 12.8 0.0 0.042 12.4 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme CobS PF02654.15 ACT01984.1 - 2.3e-57 194.5 19.0 2.7e-57 194.3 19.0 1.0 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase EcsB PF05975.12 ACT01984.1 - 0.0038 16.1 5.4 0.0066 15.3 5.3 1.4 1 1 0 1 1 1 1 Bacterial ABC transporter protein EcsB SPC25 PF06703.11 ACT01984.1 - 0.28 11.0 0.4 12 5.6 0.3 2.2 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) FUSC-like PF12805.7 ACT01984.1 - 8 5.4 7.7 0.24 10.4 1.0 1.9 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS CobD_Cbib PF03186.13 ACT01985.1 - 3e-99 331.7 1.6 3.8e-99 331.4 1.6 1.1 1 0 0 1 1 1 1 CobD/Cbib protein CobU PF02283.16 ACT01986.1 - 7.9e-59 198.0 0.1 1.4e-58 197.2 0.1 1.4 1 1 0 1 1 1 1 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA_28 PF13521.6 ACT01986.1 - 3.5e-05 24.1 0.1 5.8e-05 23.4 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT01986.1 - 0.00077 19.9 0.3 0.0038 17.6 0.3 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ACT01986.1 - 0.0017 18.8 0.0 0.0034 17.8 0.0 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ACT01986.1 - 0.014 15.9 0.1 0.022 15.3 0.1 1.7 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 ACT01986.1 - 0.015 14.6 0.0 0.055 12.8 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_33 PF13671.6 ACT01986.1 - 0.032 14.4 0.0 0.088 13.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 ACT01986.1 - 0.035 13.9 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein DNA_photolyase PF00875.18 ACT01986.1 - 0.044 13.8 0.0 0.32 11.0 0.0 2.0 1 1 1 2 2 2 0 DNA photolyase RNA_helicase PF00910.22 ACT01986.1 - 0.14 12.6 0.0 0.4 11.1 0.0 1.8 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.6 ACT01986.1 - 0.17 11.9 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 ACT01986.1 - 0.18 11.0 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain PAC4 PF16093.5 ACT01986.1 - 0.18 12.0 0.0 32 4.8 0.0 2.7 3 0 0 3 3 3 0 Proteasome assembly chaperone 4 Dynamin_N PF00350.23 ACT01986.1 - 0.24 11.5 0.2 0.36 10.9 0.2 1.6 1 1 0 1 1 1 0 Dynamin family DBI_PRT PF02277.17 ACT01987.1 - 1.8e-142 474.4 8.2 2.1e-142 474.3 8.2 1.0 1 0 0 1 1 1 1 Phosphoribosyltransferase AAA_32 PF13654.6 ACT01987.1 - 0.14 10.9 0.5 0.23 10.2 0.0 1.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ACT01988.1 - 1.1e-31 110.1 0.0 1.6e-31 109.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01988.1 - 5.5e-09 36.3 0.5 2.7e-05 24.1 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ACT01988.1 - 8.2e-06 25.8 0.2 2.1e-05 24.5 0.2 1.7 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 ACT01988.1 - 7.9e-05 22.2 0.1 0.16 11.3 0.1 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ACT01988.1 - 0.00018 22.1 0.0 0.00027 21.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT01988.1 - 0.00091 18.9 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 ACT01988.1 - 0.0015 18.5 0.2 0.058 13.4 0.0 2.5 2 1 1 3 3 3 1 AAA domain (dynein-related subfamily) AAA_15 PF13175.6 ACT01988.1 - 0.0016 18.2 0.2 0.0027 17.5 0.1 1.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_27 PF13514.6 ACT01988.1 - 0.0091 15.6 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACT01988.1 - 0.011 16.0 0.4 0.057 13.7 0.4 2.1 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACT01988.1 - 0.029 14.5 0.1 0.2 11.7 0.1 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_18 PF13238.6 ACT01988.1 - 0.029 14.9 0.0 0.1 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 ACT01988.1 - 0.032 14.1 0.1 0.063 13.2 0.1 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_16 PF13191.6 ACT01988.1 - 0.034 14.5 0.1 0.051 13.9 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ACT01988.1 - 0.081 13.3 0.0 0.66 10.4 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ACT01988.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 ACT01988.1 - 0.11 12.5 0.0 0.74 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ACT01988.1 - 0.12 12.0 0.0 0.16 11.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ACT01988.1 - 0.13 12.1 0.2 0.66 9.9 0.1 2.2 2 1 1 3 3 3 0 NTPase AAA_28 PF13521.6 ACT01988.1 - 0.17 12.1 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ACT01988.1 - 0.23 11.3 0.0 0.45 10.4 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_13 PF13166.6 ACT01988.1 - 0.33 9.5 0.0 0.51 8.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain FecCD PF01032.18 ACT01989.1 - 7.4e-98 327.4 33.5 8.9e-98 327.1 33.5 1.0 1 0 0 1 1 1 1 FecCD transport family ABC-3 PF00950.17 ACT01989.1 - 0.00071 19.1 14.4 0.0014 18.2 14.4 1.6 1 0 0 1 1 1 1 ABC 3 transport family Peripla_BP_2 PF01497.18 ACT01990.1 - 3.2e-35 121.8 3.1 4.3e-35 121.4 3.1 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Alpha_GJ PF03229.13 ACT01990.1 - 6.5 7.3 11.4 0.28 11.7 3.8 2.3 2 1 1 3 3 3 0 Alphavirus glycoprotein J E1-E2_ATPase PF00122.20 ACT01991.1 - 1.8e-51 174.2 0.5 3.5e-51 173.3 0.5 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ACT01991.1 - 1.2e-33 117.2 2.3 3.2e-33 115.8 2.3 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ACT01991.1 - 6.4e-12 45.7 0.0 1.4e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 ACT01991.1 - 6.4e-06 26.1 0.0 0.0099 15.6 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Rhodanese PF00581.20 ACT01992.1 - 1.8e-15 57.4 0.0 2e-15 57.2 0.0 1.0 1 0 0 1 1 1 1 Rhodanese-like domain DUF1992 PF09350.10 ACT01993.1 - 1e-23 83.3 0.3 1.7e-23 82.5 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) YbjQ_1 PF01906.17 ACT01994.1 - 3.8e-39 133.5 3.0 4.2e-39 133.4 3.0 1.0 1 0 0 1 1 1 1 Putative heavy-metal-binding DUF4156 PF13698.6 ACT01994.1 - 0.0085 16.4 0.2 0.022 15.1 0.0 1.8 1 1 0 2 2 2 1 Domain of unknown function (DUF4156) DUF3889 PF13028.6 ACT01995.1 - 4.4e-32 109.9 0.0 5e-32 109.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3889) VanW PF04294.13 ACT01996.1 - 4.4e-40 136.4 0.0 6.1e-40 135.9 0.0 1.2 1 0 0 1 1 1 1 VanW like protein Peptidase_S24 PF00717.23 ACT01997.1 - 1.7e-11 43.9 0.3 2.6e-11 43.3 0.3 1.3 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 ACT01997.1 - 1.7e-11 44.0 0.1 4e-11 42.9 0.1 1.6 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 MFS_1 PF07690.16 ACT01998.1 - 1e-48 166.1 53.5 1.4e-27 96.6 25.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ACT01998.1 - 3.6e-10 39.3 32.1 6.5e-09 35.1 2.2 3.2 1 1 2 3 3 3 3 MFS_1 like family MFS_4 PF06779.14 ACT01998.1 - 1.6e-09 37.6 24.1 1.4e-05 24.6 10.5 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 ACT01998.1 - 1.2e-06 27.7 35.7 0.0002 20.3 13.8 3.4 2 2 0 3 3 3 3 Sugar (and other) transporter MFS_2 PF13347.6 ACT01998.1 - 3.2e-06 26.0 41.1 0.00034 19.3 33.0 4.0 1 1 1 2 2 2 2 MFS/sugar transport protein MFS_3 PF05977.13 ACT01998.1 - 9.7 4.4 22.3 17 3.6 22.3 1.3 1 1 0 1 1 1 0 Transmembrane secretion effector ABC_tran PF00005.27 ACT01999.1 - 9e-24 84.5 0.0 1.4e-23 83.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT01999.1 - 7.7e-12 45.6 0.0 0.00012 22.1 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system CbiQ PF02361.16 ACT01999.1 - 2.9e-09 36.9 14.9 5.1e-09 36.1 14.9 1.3 1 0 0 1 1 1 1 Cobalt transport protein SMC_N PF02463.19 ACT01999.1 - 6.1e-07 29.1 0.1 0.023 14.1 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT01999.1 - 0.00011 21.9 0.2 0.00025 20.7 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACT01999.1 - 0.0016 19.0 0.1 0.0026 18.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain UAA PF08449.11 ACT01999.1 - 0.0094 15.2 0.5 0.014 14.6 0.5 1.2 1 0 0 1 1 1 1 UAA transporter family AAA_15 PF13175.6 ACT01999.1 - 0.013 15.2 0.2 0.019 14.7 0.2 1.1 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ACT01999.1 - 0.02 14.8 0.1 0.046 13.6 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_33 PF13671.6 ACT01999.1 - 0.052 13.7 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ACT01999.1 - 0.078 13.2 0.0 1.3 9.3 0.0 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 ACT01999.1 - 0.31 11.4 0.0 0.31 11.4 0.0 2.5 2 1 0 2 2 1 0 AAA ATPase domain ABC_tran PF00005.27 ACT02000.1 - 3.1e-22 79.6 0.1 4.8e-22 79.0 0.1 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT02000.1 - 1.7e-11 44.0 0.0 8.7e-11 41.7 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT02000.1 - 2.4e-07 30.9 0.0 0.0017 18.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_13 PF13166.6 ACT02000.1 - 0.0023 16.7 0.0 0.0031 16.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT02000.1 - 0.0091 15.7 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ACT02000.1 - 0.0091 16.3 0.1 0.042 14.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 ACT02000.1 - 0.032 13.9 0.0 0.037 13.7 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 ACT02000.1 - 0.052 13.8 0.2 0.45 10.8 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 ACT02000.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ACT02000.1 - 0.17 11.2 0.1 8.1 5.7 0.1 2.1 2 0 0 2 2 2 0 KaiC AAA_23 PF13476.6 ACT02000.1 - 0.22 12.0 0.0 0.32 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain BioY PF02632.14 ACT02001.1 - 6.5e-34 116.9 14.0 6.5e-34 116.9 14.0 1.4 2 0 0 2 2 2 1 BioY family ECF-ribofla_trS PF07155.12 ACT02001.1 - 2.2e-05 24.5 12.5 2.5e-05 24.3 5.3 2.2 2 0 0 2 2 2 2 ECF-type riboflavin transporter, S component ECF_trnsprt PF12822.7 ACT02001.1 - 0.00014 22.0 19.4 0.00018 21.6 19.4 1.1 1 0 0 1 1 1 1 ECF transporter, substrate-specific component MerE PF05052.12 ACT02001.1 - 0.021 14.7 0.5 0.047 13.6 0.5 1.6 1 0 0 1 1 1 0 MerE protein Rhomboid PF01694.22 ACT02001.1 - 0.31 11.0 14.0 0.1 12.6 6.5 2.4 1 1 1 2 2 2 0 Rhomboid family Colicin_V PF02674.16 ACT02001.1 - 1.1 9.3 17.3 0.27 11.2 4.5 2.4 2 1 0 2 2 2 0 Colicin V production protein Peptidase_S66 PF02016.15 ACT02002.1 - 1.1e-24 86.8 0.0 1.6e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 LD-carboxypeptidase N-terminal domain Peptidase_S66C PF17676.1 ACT02002.1 - 1.4e-24 87.0 0.0 2.2e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 LD-carboxypeptidase C-terminal domain Fe-ADH PF00465.19 ACT02003.1 - 1.8e-102 342.9 0.0 2e-102 342.7 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 ACT02003.1 - 1.8e-15 57.3 0.1 7.9e-13 48.7 0.1 2.1 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Com_YlbF PF06133.11 ACT02004.1 - 1.3e-20 73.9 7.3 1.7e-20 73.6 7.3 1.1 1 0 0 1 1 1 1 Control of competence regulator ComK, YlbF/YmcA Radical_SAM PF04055.21 ACT02005.1 - 1.7e-32 113.1 0.1 2.7e-32 112.4 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.20 ACT02005.1 - 8.5e-28 96.3 0.1 1.9e-27 95.2 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 ACT02005.1 - 9.9e-15 54.3 0.1 1.9e-14 53.4 0.1 1.5 1 0 0 1 1 1 1 TRAM domain TRAM_2 PF18693.1 ACT02005.1 - 0.13 12.5 0.0 0.65 10.2 0.0 2.1 1 1 0 1 1 1 0 TRAM domain PTAC PF06130.12 ACT02006.1 - 1e-49 166.6 0.2 6.1e-30 103.2 0.0 2.1 2 0 0 2 2 2 2 Phosphate propanoyltransferase Molydop_binding PF01568.21 ACT02006.1 - 0.021 14.9 0.5 11 6.0 0.1 3.1 2 1 1 3 3 3 0 Molydopterin dinucleotide binding domain TPP_enzyme_C PF02775.21 ACT02007.1 - 5.8e-33 113.8 0.5 1.2e-32 112.9 0.1 1.6 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PFO_beta_C PF12367.8 ACT02007.1 - 1.2e-22 79.8 0.2 2.3e-22 78.9 0.2 1.4 1 0 0 1 1 1 1 Pyruvate ferredoxin oxidoreductase beta subunit C terminal POR_N PF01855.19 ACT02008.1 - 1.2e-60 205.2 0.2 1.8e-60 204.6 0.2 1.3 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.18 ACT02008.1 - 1.6e-40 139.0 0.1 3.5e-40 137.9 0.1 1.5 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PFOR_II PF17147.4 ACT02008.1 - 1.2e-09 38.4 0.0 2.5e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II TPP_enzyme_N PF02776.18 ACT02008.1 - 8.4e-07 28.8 0.3 1.6e-06 27.8 0.3 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Transketolase_C PF02780.20 ACT02008.1 - 5.7e-05 23.0 0.0 0.00018 21.4 0.0 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain RACo_C_ter PF14574.6 ACT02008.1 - 0.017 14.2 0.1 0.04 13.0 0.1 1.5 1 0 0 1 1 1 0 C-terminal domain of RACo the ASKHA domain Peptidase_M19 PF01244.21 ACT02009.1 - 5.5e-87 291.9 0.0 6.1e-87 291.7 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Amidohydro_2 PF04909.14 ACT02009.1 - 0.0027 17.5 0.0 0.0045 16.8 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.11 ACT02009.1 - 0.05 13.1 0.0 0.06 12.8 0.0 1.1 1 0 0 1 1 1 0 Amidohydrolase family SpoVS PF04232.12 ACT02010.1 - 1e-39 134.1 1.3 1.1e-39 134.0 1.3 1.0 1 0 0 1 1 1 1 Stage V sporulation protein S (SpoVS) YmdB PF13277.6 ACT02011.1 - 2.6e-108 361.1 0.1 3e-108 361.0 0.1 1.0 1 0 0 1 1 1 1 YmdB-like protein Polysacc_deac_1 PF01522.21 ACT02011.1 - 0.0041 17.0 0.0 0.011 15.6 0.0 1.7 1 0 0 1 1 1 1 Polysaccharide deacetylase Thioredoxin_7 PF13899.6 ACT02011.1 - 0.016 15.4 0.1 0.13 12.4 0.1 2.3 2 0 0 2 2 2 0 Thioredoxin-like DUF3552 PF12072.8 ACT02012.1 - 3.5e-70 235.5 33.3 3.5e-70 235.5 33.3 1.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3552) HD PF01966.22 ACT02012.1 - 1.5e-17 64.0 4.0 1.5e-17 64.0 4.0 3.0 2 1 0 2 2 2 1 HD domain KH_1 PF00013.29 ACT02012.1 - 1.6e-06 27.8 0.2 1.6e-06 27.8 0.2 2.3 2 0 0 2 2 2 1 KH domain HDOD PF08668.12 ACT02012.1 - 1.3e-05 24.8 0.1 0.0029 17.1 0.3 2.8 2 1 0 2 2 2 1 HDOD domain KH_4 PF13083.6 ACT02012.1 - 1.5e-05 24.8 0.7 0.0001 22.1 0.1 2.8 2 1 0 2 2 2 1 KH domain KH_2 PF07650.17 ACT02012.1 - 0.024 14.5 0.5 0.024 14.5 0.5 5.3 6 2 0 7 7 7 0 KH domain Propep_M14 PF02244.16 ACT02012.1 - 0.053 13.9 0.0 0.16 12.3 0.0 1.9 1 0 0 1 1 1 0 Carboxypeptidase activation peptide V-ATPase_G PF03179.15 ACT02012.1 - 0.27 11.8 40.7 2 9.0 25.4 3.6 2 1 1 3 3 3 0 Vacuolar (H+)-ATPase G subunit DUF3402 PF11882.8 ACT02012.1 - 0.39 9.8 12.2 0.56 9.2 12.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) DUF4083 PF13314.6 ACT02012.1 - 3.9 7.5 4.7 1.2 9.1 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) RecX PF02631.16 ACT02013.1 - 1.5e-28 99.7 8.3 2.8e-28 98.8 8.3 1.4 1 0 0 1 1 1 1 RecX family Ala_racemase_N PF01168.20 ACT02013.1 - 0.00056 19.6 0.4 0.00091 18.9 0.4 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ad_Cy_reg PF16701.5 ACT02013.1 - 0.0052 16.6 0.1 0.012 15.3 0.1 1.7 1 0 0 1 1 1 1 Adenylate cyclase regulatory domain BioW PF03744.13 ACT02013.1 - 0.021 14.4 1.0 0.029 13.9 1.0 1.3 1 0 0 1 1 1 0 6-carboxyhexanoate--CoA ligase Serpin PF00079.20 ACT02013.1 - 0.094 12.0 0.0 0.14 11.4 0.0 1.5 1 1 0 1 1 1 0 Serpin (serine protease inhibitor) MSV199 PF10553.9 ACT02013.1 - 0.1 12.9 0.8 1.2 9.4 0.3 2.4 2 1 1 3 3 3 0 MSV199 domain RecA PF00154.21 ACT02014.1 - 5.6e-146 485.0 2.3 6.8e-146 484.7 2.3 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein Rad51 PF08423.11 ACT02014.1 - 2.9e-08 33.3 0.6 4.2e-07 29.5 0.2 2.5 2 1 0 2 2 2 1 Rad51 ATPase PF06745.13 ACT02014.1 - 5.7e-06 25.8 0.5 0.00014 21.3 0.5 2.7 1 1 0 1 1 1 1 KaiC AAA_24 PF13479.6 ACT02014.1 - 7.5e-05 22.5 0.0 0.00013 21.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ACT02014.1 - 0.0012 18.4 0.3 0.12 12.0 0.3 2.3 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ACT02014.1 - 0.0015 18.5 0.0 0.0029 17.6 0.0 1.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA PF00004.29 ACT02014.1 - 0.016 15.7 0.0 0.029 14.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ACT02014.1 - 0.048 14.0 0.1 0.092 13.1 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain CinA PF02464.17 ACT02015.1 - 4.4e-44 149.8 0.9 7.3e-44 149.0 0.9 1.4 1 0 0 1 1 1 1 Competence-damaged protein MoCF_biosynth PF00994.24 ACT02015.1 - 2.4e-34 118.1 0.0 2.4e-33 114.8 0.0 2.4 3 0 0 3 3 3 1 Probable molybdopterin binding domain CinA_KH PF18146.1 ACT02015.1 - 4.2e-22 78.1 0.1 1e-21 76.9 0.1 1.7 1 0 0 1 1 1 1 Damage-inducible protein CinA KH domain CDP-OH_P_transf PF01066.21 ACT02016.1 - 1.7e-15 57.5 1.8 1.7e-15 57.5 1.8 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase WCOR413 PF05562.11 ACT02016.1 - 0.003 17.5 3.3 0.003 17.5 3.3 1.7 2 0 0 2 2 2 1 Cold acclimation protein WCOR413 Insulin_TMD PF17870.1 ACT02016.1 - 2.6 8.2 9.4 0.67 10.1 2.3 3.2 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment DUF520 PF04461.13 ACT02017.1 - 7e-67 224.6 11.5 7.8e-67 224.4 11.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF520) BPA_C PF18040.1 ACT02017.1 - 0.094 12.6 0.1 0.71 9.8 0.1 2.1 2 0 0 2 2 2 0 beta porphyranase A C-terminal DinI PF06183.13 ACT02017.1 - 0.1 13.0 1.5 0.2 12.0 0.3 2.0 2 0 0 2 2 2 0 DinI-like family UPF0231 PF06062.11 ACT02017.1 - 0.11 12.8 1.7 0.24 11.7 0.4 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0231) HTH_25 PF13413.6 ACT02018.1 - 7.6e-25 86.5 0.0 1.1e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 ACT02018.1 - 9.6e-11 41.6 0.0 1.7e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ACT02018.1 - 1.3e-08 35.0 0.1 2.4e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4115 PF13464.6 ACT02018.1 - 1.2e-05 25.4 0.0 2.1e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4115) HTH_3 PF01381.22 ACT02018.1 - 4.5e-05 23.4 0.0 8.2e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix DUF896 PF05979.12 ACT02018.1 - 0.033 14.0 0.2 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) DUF3388 PF11868.8 ACT02019.1 - 1.8e-88 294.9 0.3 2.2e-88 294.6 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3388) ACT PF01842.25 ACT02019.1 - 0.00017 21.3 0.1 0.00055 19.6 0.0 1.9 2 0 0 2 2 2 1 ACT domain ACT_4 PF13291.6 ACT02019.1 - 0.0034 17.9 0.0 0.014 16.0 0.0 2.0 2 0 0 2 2 2 1 ACT domain Phage_antitermQ PF06530.12 ACT02019.1 - 0.09 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Phage antitermination protein Q DUF3243 PF11588.8 ACT02020.1 - 7.5e-35 119.1 0.5 8.3e-35 119.0 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3243) ParD PF09386.10 ACT02020.1 - 0.01 16.2 0.0 0.081 13.3 0.0 2.0 1 1 1 2 2 2 0 Antitoxin ParD Nse5 PF08691.10 ACT02020.1 - 0.025 13.3 0.0 0.025 13.3 0.0 1.0 1 0 0 1 1 1 0 DNA repair proteins Nse5 and Nse6 adh_short_C2 PF13561.6 ACT02021.1 - 1.6e-60 204.6 0.0 1.9e-60 204.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT02021.1 - 2.9e-55 186.8 1.0 3.4e-55 186.5 1.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT02021.1 - 2.5e-15 56.9 0.3 3e-15 56.6 0.3 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ACT02021.1 - 0.004 16.6 0.0 0.0055 16.1 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 ACT02021.1 - 0.0067 15.9 0.0 0.0091 15.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ACT02021.1 - 0.027 13.6 0.2 0.096 11.8 0.1 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain F420_oxidored PF03807.17 ACT02021.1 - 0.1 13.2 0.2 0.38 11.4 0.1 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 ACT02021.1 - 0.12 11.8 1.0 0.27 10.6 0.2 2.1 2 1 1 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glyco_trans_4_4 PF13579.6 ACT02021.1 - 0.15 12.5 0.0 2.9 8.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain Glyco_tran_WecB PF03808.13 ACT02021.1 - 0.17 11.8 0.1 0.35 10.8 0.0 1.5 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family Glyco_transf_5 PF08323.11 ACT02021.1 - 0.18 11.5 0.0 0.44 10.2 0.0 1.6 2 0 0 2 2 2 0 Starch synthase catalytic domain Peptidase_M16_C PF05193.21 ACT02022.1 - 1.8e-19 70.4 0.0 3.8e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ACT02022.1 - 1.2e-18 67.5 0.0 2.5e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ACT02023.1 - 7.1e-24 84.8 0.1 5.7e-23 81.9 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain Hydrolase_2 PF07486.12 ACT02024.1 - 5e-30 104.4 0.0 1.2e-29 103.2 0.0 1.6 2 0 0 2 2 2 1 Cell Wall Hydrolase PG_binding_1 PF01471.18 ACT02024.1 - 9e-18 64.2 0.1 2.6e-17 62.8 0.1 1.8 1 0 0 1 1 1 1 Putative peptidoglycan binding domain WW PF00397.26 ACT02024.1 - 0.00027 20.9 0.9 0.00063 19.8 0.9 1.6 1 0 0 1 1 1 1 WW domain PG_binding_2 PF08823.11 ACT02024.1 - 0.00054 20.2 0.0 0.0013 19.0 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain PG_binding_3 PF09374.10 ACT02024.1 - 0.0014 18.9 0.2 0.13 12.5 0.0 2.5 1 1 1 2 2 2 2 Predicted Peptidoglycan domain FtsK_SpoIIIE PF01580.18 ACT02025.1 - 2.3e-63 213.8 1.0 2.6e-45 154.7 0.0 2.4 1 1 1 2 2 2 2 FtsK/SpoIIIE family FtsK_alpha PF17854.1 ACT02025.1 - 8.8e-33 112.5 0.0 1.8e-32 111.5 0.0 1.6 1 0 0 1 1 1 1 FtsK alpha domain FtsK_gamma PF09397.10 ACT02025.1 - 2.1e-30 104.3 0.4 4.6e-30 103.2 0.4 1.6 1 0 0 1 1 1 1 Ftsk gamma domain AAA_10 PF12846.7 ACT02025.1 - 7.7e-05 21.8 0.0 0.0026 16.7 0.0 2.2 2 0 0 2 2 2 1 AAA-like domain FtsK_4TM PF13491.6 ACT02025.1 - 0.00013 21.7 12.9 0.076 12.7 12.9 2.3 1 1 0 1 1 1 1 4TM region of DNA translocase FtsK/SpoIIIE T2SSE PF00437.20 ACT02025.1 - 0.004 16.3 0.4 0.0092 15.1 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF87 PF01935.17 ACT02025.1 - 0.005 16.9 0.2 0.021 14.9 0.0 2.2 2 1 0 2 2 2 1 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 ACT02025.1 - 0.018 14.0 0.0 0.14 11.0 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ATPase_2 PF01637.18 ACT02025.1 - 0.026 14.4 0.0 0.06 13.2 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ACT02025.1 - 0.053 13.8 0.1 0.26 11.6 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ACT02025.1 - 0.062 13.6 0.2 0.27 11.5 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ACT02025.1 - 0.078 13.3 0.0 0.31 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain ResIII PF04851.15 ACT02025.1 - 0.1 12.6 0.1 0.37 10.8 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DEAD PF00270.29 ACT02025.1 - 0.18 11.6 0.1 0.5 10.1 0.0 1.7 2 0 0 2 2 2 0 DEAD/DEAH box helicase TniB PF05621.11 ACT02025.1 - 0.2 11.1 0.4 2.5 7.4 0.4 2.4 1 1 0 1 1 1 0 Bacterial TniB protein CHASE8 PF17152.4 ACT02025.1 - 0.33 11.2 2.1 14 5.9 0.3 2.7 2 0 0 2 2 2 0 Periplasmic sensor domain YlzJ PF14035.6 ACT02026.1 - 9.8e-23 80.1 0.0 1.1e-22 80.0 0.0 1.0 1 0 0 1 1 1 1 YlzJ-like protein CLP_protease PF00574.23 ACT02027.1 - 1.3e-36 126.2 0.6 1.8e-36 125.8 0.6 1.1 1 0 0 1 1 1 1 Clp protease Phage_Mu_Gp45 PF06890.12 ACT02027.1 - 0.01 15.5 0.8 0.025 14.3 0.0 2.0 3 0 0 3 3 3 0 Bacteriophage Mu Gp45 protein CLP1_P PF16575.5 ACT02027.1 - 0.031 14.1 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop GT-D PF08759.11 ACT02027.1 - 0.13 11.9 0.0 0.3 10.7 0.0 1.5 2 0 0 2 2 2 0 Glycosyltransferase GT-D fold RNase_J_C PF17770.1 ACT02028.1 - 2.2e-29 102.3 0.0 4.9e-29 101.2 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease J C-terminal domain Lactamase_B PF00753.27 ACT02028.1 - 2.3e-15 57.1 0.3 2.3e-15 57.1 0.3 2.1 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 ACT02028.1 - 2.3e-13 49.8 0.4 1.2e-11 44.3 0.1 2.7 3 0 0 3 3 3 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 ACT02028.1 - 1.5e-11 44.2 0.2 8.2e-11 41.8 0.1 2.2 2 1 1 3 3 3 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 ACT02028.1 - 0.067 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain DHDPS PF00701.22 ACT02029.1 - 2.6e-95 318.5 0.0 2.8e-95 318.3 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family AA_kinase PF00696.28 ACT02030.1 - 9.8e-46 156.3 0.3 1.5e-45 155.7 0.3 1.3 1 0 0 1 1 1 1 Amino acid kinase family ACT_7 PF13840.6 ACT02030.1 - 2.5e-22 78.4 0.8 4.4e-21 74.4 0.1 2.7 2 0 0 2 2 2 1 ACT domain ACT PF01842.25 ACT02030.1 - 2.4e-09 36.8 0.6 0.0003 20.5 0.1 3.0 2 1 0 2 2 2 2 ACT domain DUF2007 PF09413.10 ACT02030.1 - 0.00038 20.5 0.2 0.69 10.1 0.0 3.9 4 1 0 4 4 4 1 Putative prokaryotic signal transducing protein LytR_C PF13399.6 ACT02030.1 - 0.082 13.9 0.2 1.1 10.3 0.0 2.8 2 1 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator Flavoprotein PF02441.19 ACT02031.1 - 5.1e-11 42.6 0.3 6.3e-11 42.3 0.3 1.1 1 0 0 1 1 1 1 Flavoprotein DpaA_N PF16924.5 ACT02032.1 - 9.2e-31 106.3 0.0 5.3e-30 103.9 0.0 2.0 2 0 0 2 2 2 1 Dipicolinate synthase subunit A N-terminal domain IlvN PF07991.12 ACT02032.1 - 2e-05 24.2 0.0 5.3e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 ACT02032.1 - 2.8e-05 23.6 0.1 4.9e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ACT02032.1 - 4.6e-05 22.8 0.2 0.00043 19.7 0.2 2.4 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AdoHcyase_NAD PF00670.21 ACT02032.1 - 0.002 18.2 0.2 0.0041 17.2 0.2 1.5 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 ACT02032.1 - 0.0021 18.5 0.0 0.13 12.7 0.0 2.3 2 0 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_2 PF03446.15 ACT02032.1 - 0.0045 17.2 0.0 0.01 16.0 0.0 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACT02032.1 - 0.0065 17.0 0.0 0.012 16.2 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.27 ACT02032.1 - 0.0084 16.7 0.0 0.055 14.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 ACT02032.1 - 0.017 15.4 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 ACT02032.1 - 0.045 13.8 0.0 0.08 13.0 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 ACT02032.1 - 0.075 12.3 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Oxidored_nitro PF00148.19 ACT02032.1 - 0.096 11.4 0.0 1.5 7.5 0.0 2.2 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase dUTPase PF00692.19 ACT02033.1 - 4.8e-32 110.3 0.0 5.5e-32 110.2 0.0 1.0 1 0 0 1 1 1 1 dUTPase Peptidase_M16_C PF05193.21 ACT02034.1 - 1.3e-44 152.4 0.1 2.5e-44 151.5 0.1 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ACT02034.1 - 1.2e-43 148.7 0.0 4.2e-43 146.9 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DUF1054 PF06335.12 ACT02034.1 - 0.044 13.7 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1054) Polysacc_deac_1 PF01522.21 ACT02035.1 - 8.9e-30 103.1 0.0 1.6e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ACT02035.1 - 5.9e-05 22.4 0.0 7.1e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Spore_III_AF PF09581.10 ACT02035.1 - 0.053 13.6 0.0 0.083 12.9 0.0 1.3 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) PG_binding_4 PF12229.8 ACT02035.1 - 0.064 13.5 0.7 0.65 10.3 0.1 2.5 3 0 0 3 3 3 0 Putative peptidoglycan binding domain DUF2334 PF10096.9 ACT02035.1 - 0.068 12.8 0.2 0.17 11.6 0.2 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) CoA_binding_2 PF13380.6 ACT02035.1 - 0.085 13.3 0.0 2.2 8.8 0.0 2.4 2 0 0 2 2 2 0 CoA binding domain RNase_PH PF01138.21 ACT02036.1 - 1.7e-40 138.6 0.0 3.9e-19 69.4 0.0 2.7 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ACT02036.1 - 4.5e-22 77.9 2.4 1.2e-13 50.8 0.4 2.7 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 S1 PF00575.23 ACT02036.1 - 5.3e-19 68.3 4.2 7.9e-19 67.8 2.9 2.0 1 1 1 2 2 2 1 S1 RNA binding domain PNPase PF03726.14 ACT02036.1 - 9.6e-16 58.1 1.1 9.6e-16 58.1 1.1 2.1 2 0 0 2 2 2 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain KH_1 PF00013.29 ACT02036.1 - 7.4e-11 41.7 10.2 1.2e-08 34.7 4.3 3.3 3 0 0 3 3 3 2 KH domain SPATA25 PF15218.6 ACT02036.1 - 0.0028 17.5 0.1 0.0055 16.5 0.1 1.4 1 0 0 1 1 1 1 Spermatogenesis-associated protein 25 S1_2 PF13509.6 ACT02036.1 - 0.037 14.1 0.3 0.21 11.6 0.3 2.3 1 1 0 1 1 1 0 S1 domain EXOSC1 PF10447.9 ACT02036.1 - 0.38 11.4 3.2 0.87 10.2 0.3 2.9 3 0 0 3 3 3 0 Exosome component EXOSC1/CSL4 Ribosomal_S15 PF00312.22 ACT02037.1 - 6.4e-38 128.8 3.5 7.4e-38 128.6 3.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S15 Stirrup PF09061.6 ACT02037.1 - 0.014 15.6 0.7 0.018 15.2 0.6 1.3 1 1 0 1 1 1 0 Stirrup FAD_syn PF06574.12 ACT02038.1 - 1.6e-50 171.1 0.1 2.3e-50 170.6 0.1 1.2 1 0 0 1 1 1 1 FAD synthetase Flavokinase PF01687.17 ACT02038.1 - 5e-34 116.9 0.0 7.7e-34 116.3 0.0 1.3 1 0 0 1 1 1 1 Riboflavin kinase CTP_transf_like PF01467.26 ACT02038.1 - 0.00053 20.2 0.3 0.0093 16.2 0.3 2.3 1 1 0 1 1 1 1 Cytidylyltransferase-like Citrate_ly_lig PF08218.11 ACT02038.1 - 0.0015 18.2 0.0 0.0031 17.2 0.0 1.4 1 0 0 1 1 1 1 Citrate lyase ligase C-terminal domain TruB_N PF01509.18 ACT02039.1 - 1.9e-59 200.3 0.0 3.5e-59 199.5 0.0 1.4 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 ACT02039.1 - 7.1e-16 58.1 0.6 3e-15 56.1 0.3 2.2 1 1 1 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain TruB-C_2 PF09157.11 ACT02039.1 - 0.00011 22.1 0.0 0.00021 21.2 0.0 1.5 1 0 0 1 1 1 1 Pseudouridine synthase II TruB, C-terminal DNA_pol3_finger PF17657.1 ACT02039.1 - 0.046 13.1 0.2 0.11 11.8 0.2 1.7 1 0 0 1 1 1 0 Bacterial DNA polymerase III alpha subunit finger domain DHH PF01368.20 ACT02040.1 - 5.3e-12 45.9 0.0 8.1e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 DHH family DHHA1 PF02272.19 ACT02040.1 - 2.6e-11 44.1 0.4 4.8e-11 43.2 0.4 1.5 1 0 0 1 1 1 1 DHHA1 domain F420H2_quin_red PF04075.14 ACT02040.1 - 0.082 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 F420H(2)-dependent quinone reductase Corona_S1 PF01600.16 ACT02040.1 - 0.25 10.1 0.0 0.39 9.4 0.0 1.2 1 0 0 1 1 1 0 Coronavirus S1 glycoprotein RBFA PF02033.18 ACT02041.1 - 2.2e-35 121.3 0.0 2.5e-35 121.1 0.0 1.0 1 0 0 1 1 1 1 Ribosome-binding factor A IF-2 PF11987.8 ACT02042.1 - 2.1e-37 127.4 3.3 6.8e-37 125.8 3.3 2.0 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU PF00009.27 ACT02042.1 - 7e-35 120.3 6.6 4.7e-33 114.4 4.8 3.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF2_N PF04760.15 ACT02042.1 - 1e-25 89.3 5.3 1.3e-14 53.7 0.6 2.5 2 0 0 2 2 2 2 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.23 ACT02042.1 - 2.6e-10 40.4 0.4 7.1e-10 39.0 0.4 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 ACT02042.1 - 7.1e-06 25.6 0.0 1.9e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ACT02042.1 - 1e-05 25.2 0.0 2.4e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Ras family FeoB_N PF02421.18 ACT02042.1 - 3.4e-05 23.4 0.3 8.9e-05 22.1 0.3 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 ACT02042.1 - 7.8e-05 22.2 0.1 0.00036 20.0 0.1 2.0 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 ACT02042.1 - 0.00013 21.7 0.4 0.00052 19.8 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU_D2 PF03144.25 ACT02042.1 - 0.00018 21.8 2.7 0.0012 19.2 0.8 3.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Roc PF08477.13 ACT02042.1 - 0.0035 17.5 0.1 0.023 14.9 0.1 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1_Xtn PF16897.5 ACT02042.1 - 0.012 15.6 1.7 0.054 13.5 0.0 2.9 3 1 1 4 4 3 0 C-terminal region of MMR_HSR1 domain AAA_29 PF13555.6 ACT02042.1 - 0.083 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ANT PF03374.14 ACT02042.1 - 0.085 13.2 0.0 8.4 6.8 0.0 2.7 2 0 0 2 2 2 0 Phage antirepressor protein KilAC domain GTP_EFTU_D4 PF14578.6 ACT02042.1 - 0.2 11.6 4.5 0.23 11.4 1.2 2.7 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Macoilin PF09726.9 ACT02042.1 - 2.3 6.7 18.7 4.2 5.8 18.7 1.3 1 0 0 1 1 1 0 Macoilin family FAM70 PF14967.6 ACT02042.1 - 2.3 7.6 5.4 3.5 7.0 5.4 1.2 1 0 0 1 1 1 0 FAM70 protein Ribosomal_L7Ae PF01248.26 ACT02043.1 - 3.7e-18 65.0 0.1 4.4e-18 64.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF448 PF04296.13 ACT02044.1 - 7.2e-31 105.9 1.2 8.6e-31 105.6 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF448) CEBP_ZZ PF16366.5 ACT02044.1 - 0.037 14.3 0.1 0.054 13.7 0.1 1.2 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain BaffR-Tall_bind PF09256.10 ACT02044.1 - 0.069 12.9 1.9 1.2 9.0 0.1 2.5 2 0 0 2 2 2 0 BAFF-R, TALL-1 binding LupA PF18242.1 ACT02044.1 - 0.14 11.8 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Legionella ubiquitin-specific protease A domain NusA_N PF08529.11 ACT02045.1 - 2.8e-43 147.1 3.0 7.4e-43 145.8 3.0 1.7 1 0 0 1 1 1 1 NusA N-terminal domain KH_5 PF13184.6 ACT02045.1 - 1.8e-28 98.4 0.5 2.1e-27 95.0 0.2 2.5 2 0 0 2 2 2 1 NusA-like KH domain S1 PF00575.23 ACT02045.1 - 9.6e-11 41.9 0.8 2.7e-10 40.4 0.2 2.1 2 0 0 2 2 2 1 S1 RNA binding domain DUF150 PF02576.17 ACT02046.1 - 9.8e-28 96.4 0.1 1.4e-27 95.9 0.1 1.2 1 0 0 1 1 1 1 RimP N-terminal domain DUF150_C PF17384.2 ACT02046.1 - 4.6e-16 58.7 0.1 8.4e-16 57.9 0.1 1.5 1 0 0 1 1 1 1 RimP C-terminal SH3 domain DNA_pol3_alpha PF07733.12 ACT02047.1 - 8.7e-56 189.4 0.0 3e-52 177.8 0.0 2.5 1 1 0 1 1 1 1 Bacterial DNA polymerase III alpha NTPase domain PHP PF02811.19 ACT02047.1 - 1.7e-44 152.1 0.6 7.8e-44 149.9 0.2 2.2 2 0 0 2 2 2 1 PHP domain RNase_T PF00929.24 ACT02047.1 - 2.2e-33 116.2 0.1 5.1e-33 114.9 0.1 1.7 1 0 0 1 1 1 1 Exonuclease DNA_pol3_finger PF17657.1 ACT02047.1 - 3.7e-24 85.0 0.0 8.2e-24 83.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha subunit finger domain DNA_pol3_a_NI PF14480.6 ACT02047.1 - 7.5e-18 64.3 0.3 4e-17 62.0 0.0 2.5 3 0 0 3 3 3 1 DNA polymerase III polC-type N-terminus I DNA_pol3_a_NII PF11490.8 ACT02047.1 - 1.3e-12 47.6 0.2 3.2e-12 46.4 0.2 1.7 1 0 0 1 1 1 1 DNA polymerase III polC-type N-terminus II HHH_6 PF14579.6 ACT02047.1 - 3.2e-11 43.3 0.0 1.1e-10 41.6 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif RNase_H_2 PF13482.6 ACT02047.1 - 0.00035 20.6 0.0 0.0016 18.5 0.0 2.1 1 1 0 1 1 1 1 RNase_H superfamily tRNA_anti-codon PF01336.25 ACT02047.1 - 0.0004 20.3 0.0 0.001 19.0 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DNA_pol_A_exo1 PF01612.20 ACT02047.1 - 0.015 15.1 0.1 0.14 11.9 0.1 2.2 1 1 0 1 1 1 0 3'-5' exonuclease STI1 PF17830.1 ACT02047.1 - 1.8 8.6 7.5 0.21 11.5 2.9 1.9 2 0 0 2 2 2 0 STI1 domain ProRS-C_1 PF09180.11 ACT02048.1 - 4.8e-24 84.4 1.2 1.2e-23 83.0 1.2 1.8 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 ACT02048.1 - 2.2e-19 70.1 0.1 3.8e-19 69.3 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ACT02048.1 - 1.9e-17 63.2 0.1 4.1e-17 62.1 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain Peptidase_M50 PF02163.22 ACT02049.1 - 3.4e-68 229.6 1.4 4.2e-68 229.3 1.4 1.1 1 0 0 1 1 1 1 Peptidase family M50 PDZ_2 PF13180.6 ACT02049.1 - 8.4e-11 42.1 0.1 1.9e-10 40.9 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ACT02049.1 - 2.7e-09 36.7 0.1 7.9e-09 35.2 0.1 1.9 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 ACT02049.1 - 5e-05 23.6 0.4 0.0001 22.6 0.4 1.5 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 ACT02049.1 - 0.11 12.4 0.0 0.88 9.6 0.1 2.4 2 0 0 2 2 2 0 Tricorn protease PDZ domain DUF456 PF04306.13 ACT02049.1 - 0.3 11.4 0.1 0.3 11.4 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF456) DXP_reductoisom PF02670.16 ACT02050.1 - 3e-48 163.8 1.3 5.1e-48 163.0 1.3 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DXPR_C PF13288.6 ACT02050.1 - 6.7e-43 145.6 0.0 1.3e-42 144.7 0.0 1.5 1 0 0 1 1 1 1 DXP reductoisomerase C-terminal domain DXP_redisom_C PF08436.12 ACT02050.1 - 9.1e-41 137.9 0.0 2e-40 136.8 0.0 1.6 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain NAD_binding_3 PF03447.16 ACT02050.1 - 0.00098 19.8 0.8 0.0051 17.4 0.8 2.0 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ACT02050.1 - 0.061 13.8 0.1 0.61 10.5 0.1 2.4 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain CTP_transf_1 PF01148.20 ACT02051.1 - 3e-63 214.1 14.2 3.6e-63 213.8 14.2 1.0 1 0 0 1 1 1 1 Cytidylyltransferase family DsbB PF02600.16 ACT02051.1 - 1.6 9.2 11.8 6.5 7.2 0.8 3.0 2 1 1 3 3 3 0 Disulfide bond formation protein DsbB Prenyltransf PF01255.19 ACT02052.1 - 8.5e-83 277.3 0.0 9.8e-83 277.1 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Glyco_hydro_97 PF10566.9 ACT02052.1 - 0.058 12.7 0.0 0.081 12.2 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase 97 RRF PF01765.19 ACT02053.1 - 5.3e-67 224.8 1.8 6.9e-67 224.4 1.8 1.1 1 0 0 1 1 1 1 Ribosome recycling factor 4HB_MCP_1 PF12729.7 ACT02053.1 - 0.046 13.3 4.4 0.034 13.7 2.0 1.9 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction TPD52 PF04201.15 ACT02053.1 - 0.37 10.4 7.2 0.34 10.5 2.7 2.6 2 1 1 3 3 3 0 Tumour protein D52 family AA_kinase PF00696.28 ACT02054.1 - 3.9e-27 95.4 1.7 4.7e-27 95.1 1.7 1.0 1 0 0 1 1 1 1 Amino acid kinase family DHHA1 PF02272.19 ACT02054.1 - 0.11 12.9 3.8 2.7 8.4 0.3 2.6 2 1 0 2 2 2 0 DHHA1 domain Radical_SAM PF04055.21 ACT02054.1 - 0.21 11.9 0.4 12 6.2 0.0 2.2 2 0 0 2 2 2 0 Radical SAM superfamily EF_TS PF00889.19 ACT02055.1 - 9.2e-48 162.6 9.6 1.2e-46 158.9 9.6 3.0 1 1 0 1 1 1 1 Elongation factor TS HOIP-UBA PF16678.5 ACT02055.1 - 0.0038 17.2 0.5 0.11 12.5 0.1 2.3 2 0 0 2 2 2 1 HOIP UBA domain pair TOBE_2 PF08402.10 ACT02055.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 TOBE domain Ribosomal_S2 PF00318.20 ACT02056.1 - 4.3e-101 336.6 0.0 4.8e-101 336.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S2 YceG PF02618.16 ACT02057.1 - 0.00029 20.5 0.2 0.00046 19.8 0.0 1.4 2 0 0 2 2 2 1 YceG-like family DUF1043 PF06295.12 ACT02057.1 - 0.14 12.2 0.2 0.14 12.2 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) DUF1003 PF06210.11 ACT02058.1 - 0.004 17.2 0.8 0.004 17.2 0.8 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1003) DUF2802 PF10975.8 ACT02058.1 - 0.0078 16.3 8.0 0.011 15.8 0.0 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2802) HTH_38 PF13936.6 ACT02058.1 - 0.024 14.4 0.0 0.059 13.2 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain ApoO PF09769.9 ACT02058.1 - 0.037 14.0 0.8 1 9.3 0.4 2.1 1 1 1 2 2 2 0 Apolipoprotein O HTH_40 PF14493.6 ACT02058.1 - 0.039 14.4 1.2 0.16 12.5 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain Phage_antitermQ PF06530.12 ACT02058.1 - 0.044 13.7 0.3 0.88 9.5 0.0 2.2 2 1 0 2 2 2 0 Phage antitermination protein Q Fungal_trans_2 PF11951.8 ACT02058.1 - 0.082 11.7 1.6 1.1 8.0 0.0 2.0 1 1 1 2 2 2 0 Fungal specific transcription factor domain HTH_7 PF02796.15 ACT02058.1 - 0.11 12.5 0.1 1.5 9.0 0.0 2.5 2 1 0 2 2 2 0 Helix-turn-helix domain of resolvase TBD PF12845.7 ACT02059.1 - 0.0024 17.7 0.7 0.0034 17.2 0.1 1.6 2 0 0 2 2 2 1 TBD domain CDH1_2_SANT_HL1 PF18375.1 ACT02059.1 - 0.32 11.7 2.4 0.55 11.0 2.4 1.5 1 1 0 1 1 1 0 CDH1/2 SANT-Helical linker 1 FapA PF03961.13 ACT02060.1 - 8.2e-117 390.6 12.7 9.2e-117 390.4 12.7 1.0 1 0 0 1 1 1 1 Flagellar Assembly Protein A MinC_C PF03775.16 ACT02060.1 - 0.023 14.7 2.7 0.023 14.7 2.7 2.9 1 1 2 3 3 3 0 Septum formation inhibitor MinC, C-terminal domain Pox_A_type_inc PF04508.12 ACT02060.1 - 0.44 10.5 6.2 0.39 10.7 3.4 2.3 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DUF4140 PF13600.6 ACT02060.1 - 0.55 10.7 5.2 2.3 8.7 0.3 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Sigma70_r4 PF04545.16 ACT02061.1 - 5e-17 61.2 2.2 3.1e-16 58.6 0.5 2.3 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACT02061.1 - 1.3e-12 47.3 0.0 4.9e-12 45.4 0.0 2.0 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT02061.1 - 1e-10 41.1 2.9 1.2e-08 34.5 0.5 2.4 2 0 0 2 2 2 2 Sigma-70, region 4 Sigma70_r3 PF04539.16 ACT02061.1 - 4.7e-07 29.8 4.1 1.4e-05 25.1 1.8 2.4 2 0 0 2 2 2 1 Sigma-70 region 3 UPF0122 PF04297.14 ACT02061.1 - 4e-06 27.0 0.5 2.2e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 Putative helix-turn-helix protein, YlxM / p13 like Phage_antitermQ PF06530.12 ACT02061.1 - 8.7e-05 22.4 0.5 0.47 10.4 0.0 2.4 2 0 0 2 2 2 2 Phage antitermination protein Q HTH_38 PF13936.6 ACT02061.1 - 0.00012 21.8 0.1 0.00039 20.1 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 ACT02061.1 - 0.0089 15.8 1.8 0.25 11.2 0.0 2.8 3 0 0 3 3 3 1 Homeodomain-like domain GerE PF00196.19 ACT02061.1 - 0.019 14.5 0.6 0.25 10.9 0.2 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Sigma70_ECF PF07638.11 ACT02061.1 - 0.048 13.6 1.0 0.67 9.8 0.1 2.6 3 0 0 3 3 3 0 ECF sigma factor HTH_Mga PF08280.11 ACT02061.1 - 0.048 13.7 0.5 6.5 6.9 0.0 2.5 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_5 PF01022.20 ACT02061.1 - 0.065 13.1 0.4 0.36 10.7 0.1 2.2 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_10 PF04967.12 ACT02061.1 - 0.08 12.8 1.0 13 5.7 0.0 3.1 2 1 0 2 2 2 0 HTH DNA binding domain MarR_2 PF12802.7 ACT02061.1 - 0.12 12.3 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 MarR family CheD PF03975.13 ACT02063.1 - 2.2e-34 117.8 0.0 3.3e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 CheD chemotactic sensory transduction CheW PF01584.19 ACT02064.1 - 6e-39 132.8 0.6 6.9e-39 132.6 0.6 1.0 1 0 0 1 1 1 1 CheW-like domain CheW PF01584.19 ACT02065.1 - 1.2e-25 89.8 1.1 2.1e-25 89.0 0.3 1.8 2 0 0 2 2 2 1 CheW-like domain P2 PF07194.11 ACT02065.1 - 2.1e-25 88.6 1.8 5.1e-25 87.3 1.1 2.1 2 0 0 2 2 2 1 P2 response regulator binding domain Hpt PF01627.23 ACT02065.1 - 1.3e-18 67.0 0.7 3.7e-18 65.6 0.1 2.1 2 0 0 2 2 2 1 Hpt domain HATPase_c PF02518.26 ACT02065.1 - 3.7e-17 62.8 0.5 9.9e-17 61.5 0.5 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase H-kinase_dim PF02895.14 ACT02065.1 - 1e-13 51.4 5.9 5.5e-13 49.1 4.9 2.7 2 0 0 2 2 2 1 Signal transducing histidine kinase, homodimeric domain Sigma54_DBD PF04552.13 ACT02065.1 - 0.04 13.6 0.1 0.11 12.1 0.1 1.7 1 0 0 1 1 1 0 Sigma-54, DNA binding domain PBECR3 PF18812.1 ACT02065.1 - 0.086 12.8 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 CheB_methylest PF01339.17 ACT02066.1 - 8.9e-61 204.5 0.2 1.6e-60 203.7 0.2 1.4 1 0 0 1 1 1 1 CheB methylesterase Response_reg PF00072.24 ACT02066.1 - 3.2e-24 85.2 0.0 7.6e-24 84.0 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain ParA PF10609.9 ACT02067.1 - 2.7e-20 72.9 0.2 1.1e-12 48.0 0.2 2.1 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ACT02067.1 - 6.8e-20 71.4 0.0 9.2e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ACT02067.1 - 2.6e-18 66.6 0.0 3.6e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain CBP_BcsQ PF06564.12 ACT02067.1 - 1.9e-09 37.4 0.0 1.9e-08 34.1 0.0 2.0 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 ACT02067.1 - 5.9e-08 32.5 0.1 2.4e-07 30.5 0.1 1.8 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 ACT02067.1 - 1.5e-06 27.6 1.3 3.9e-05 23.0 0.2 2.5 2 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 ACT02067.1 - 6e-05 22.5 0.1 0.00074 18.9 0.1 2.1 1 1 0 1 1 1 1 ATPase MipZ AAA_24 PF13479.6 ACT02067.1 - 0.00052 19.8 0.1 0.0008 19.2 0.1 1.3 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.5 ACT02067.1 - 0.01 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop VirC1 PF07015.11 ACT02067.1 - 0.05 12.9 0.3 0.42 9.9 0.1 2.0 2 0 0 2 2 2 0 VirC1 protein MeaB PF03308.16 ACT02067.1 - 0.072 12.1 0.1 0.43 9.5 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54 PF00448.22 ACT02068.1 - 2.2e-36 125.4 0.0 2.2e-36 125.4 0.0 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 ACT02068.1 - 0.0022 18.4 1.0 0.027 14.9 0.0 2.7 2 2 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ACT02068.1 - 0.0033 17.7 0.1 0.013 15.8 0.1 2.1 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ACT02068.1 - 0.0055 16.6 0.2 0.032 14.2 0.1 2.3 1 1 1 2 2 2 1 RsgA GTPase ResIII PF04851.15 ACT02068.1 - 0.0059 16.6 0.1 0.044 13.8 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_33 PF13671.6 ACT02068.1 - 0.0075 16.4 0.1 0.028 14.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ACT02068.1 - 0.012 15.7 0.1 0.038 14.1 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA PF00004.29 ACT02068.1 - 0.014 15.8 0.2 0.048 14.1 0.2 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ACT02068.1 - 0.016 15.2 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ACT02068.1 - 0.018 14.6 0.1 0.054 13.0 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 ACT02068.1 - 0.032 13.9 5.3 0.034 13.9 0.2 2.5 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ACT02068.1 - 0.042 14.3 0.0 0.094 13.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Rad17 PF03215.15 ACT02068.1 - 0.045 13.7 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_23 PF13476.6 ACT02068.1 - 0.076 13.5 0.2 0.34 11.4 0.1 2.1 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ACT02068.1 - 0.084 13.1 0.0 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ACT02068.1 - 0.088 12.4 0.0 0.25 10.9 0.0 1.8 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain FHIPEP PF00771.20 ACT02069.1 - 3.6e-278 924.5 16.0 4.1e-278 924.3 16.0 1.0 1 0 0 1 1 1 1 FHIPEP family MutS_III PF05192.18 ACT02069.1 - 0.3 11.3 0.8 0.62 10.3 0.6 1.6 2 0 0 2 2 2 0 MutS domain III Bac_export_2 PF01312.19 ACT02070.1 - 5.7e-134 446.5 7.6 6.4e-134 446.3 7.6 1.0 1 0 0 1 1 1 1 FlhB HrpN YscU SpaS Family DUF3742 PF12553.8 ACT02070.1 - 0.067 13.3 0.2 0.067 13.3 0.2 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3742) POR PF01558.18 ACT02070.1 - 0.087 12.9 0.2 0.14 12.2 0.2 1.3 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Bac_export_1 PF01311.20 ACT02071.1 - 3.8e-70 236.0 29.8 4.4e-70 235.8 29.8 1.0 1 0 0 1 1 1 1 Bacterial export proteins, family 1 Bac_export_3 PF01313.19 ACT02072.1 - 3.6e-31 106.9 11.1 4.2e-31 106.7 11.1 1.1 1 0 0 1 1 1 1 Bacterial export proteins, family 3 ECF-ribofla_trS PF07155.12 ACT02072.1 - 0.0032 17.5 4.4 0.0037 17.3 4.4 1.0 1 0 0 1 1 1 1 ECF-type riboflavin transporter, S component ThrE PF06738.12 ACT02072.1 - 0.017 14.5 3.4 0.019 14.3 3.4 1.0 1 0 0 1 1 1 0 Putative threonine/serine exporter DUF5357 PF17310.2 ACT02072.1 - 0.18 10.3 3.9 0.22 10.1 3.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5357) Bac_export_2 PF01312.19 ACT02072.1 - 0.88 8.7 4.9 1.1 8.4 3.3 1.7 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family PsbI PF02532.14 ACT02072.1 - 9.2 6.3 8.9 3.9 7.5 2.1 2.3 2 0 0 2 2 2 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) FliP PF00813.20 ACT02073.1 - 4.5e-82 274.6 19.1 7.4e-82 273.9 19.1 1.3 1 0 0 1 1 1 1 FliP family DUF4905 PF16248.5 ACT02073.1 - 0.014 15.3 0.0 0.49 10.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4905) FliO PF04347.13 ACT02074.1 - 2.2e-11 43.9 2.1 9e-11 41.9 2.1 1.9 1 1 0 1 1 1 1 Flagellar biosynthesis protein, FliO Neurensin PF14927.6 ACT02074.1 - 0.021 14.5 0.5 0.034 13.8 0.5 1.3 1 0 0 1 1 1 0 Neurensin DUF416 PF04222.12 ACT02074.1 - 0.046 13.1 1.7 0.062 12.7 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF416) DUF3437 PF11919.8 ACT02074.1 - 0.16 11.9 0.6 0.27 11.2 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) OSTbeta PF15048.6 ACT02074.1 - 0.46 10.6 3.2 5.6 7.1 0.0 2.2 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein MatE PF01554.18 ACT02074.1 - 0.8 9.3 4.5 1.3 8.6 1.4 2.0 2 0 0 2 2 2 0 MatE Response_reg PF00072.24 ACT02075.1 - 7.9e-35 119.4 3.5 8.8e-35 119.3 3.5 1.0 1 0 0 1 1 1 1 Response regulator receiver domain B12-binding PF02310.19 ACT02075.1 - 0.039 14.0 0.0 0.092 12.8 0.0 1.7 1 1 0 1 1 1 0 B12 binding domain HydF_dimer PF18128.1 ACT02075.1 - 0.063 13.4 0.1 0.38 10.8 0.0 2.0 1 1 0 2 2 2 0 Hydrogen maturase F dimerization domain CheC PF04509.12 ACT02076.1 - 1.4e-29 101.6 4.3 6.7e-16 57.9 0.1 2.5 2 0 0 2 2 2 2 CheC-like family FliMN_C PF01052.20 ACT02076.1 - 3.5e-25 87.8 2.6 6.5e-25 86.9 2.6 1.5 1 0 0 1 1 1 1 Type III flagellar switch regulator (C-ring) FliN C-term CheX PF13690.6 ACT02076.1 - 5.1e-09 36.2 0.5 0.00037 20.6 0.0 2.5 2 0 0 2 2 2 2 Chemotaxis phosphatase CheX FliM PF02154.15 ACT02076.1 - 0.00014 21.8 0.2 0.00027 20.9 0.2 1.4 1 0 0 1 1 1 1 Flagellar motor switch protein FliM DEC-1_N PF04625.13 ACT02076.1 - 0.014 14.4 7.9 0.027 13.5 7.9 1.5 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region FliM PF02154.15 ACT02077.1 - 5.1e-72 241.8 1.7 7.2e-72 241.3 1.7 1.2 1 0 0 1 1 1 1 Flagellar motor switch protein FliM FliMN_C PF01052.20 ACT02077.1 - 1.8e-20 72.7 0.7 3e-20 72.0 0.7 1.4 1 0 0 1 1 1 1 Type III flagellar switch regulator (C-ring) FliN C-term Rep_4 PF05797.11 ACT02077.1 - 0.064 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Yeast trans-acting factor (REP1/REP2) ABC2_membrane_3 PF12698.7 ACT02079.1 - 0.01 14.9 0.3 0.012 14.7 0.3 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein FlbD PF06289.11 ACT02080.1 - 3.9e-26 90.4 1.2 4.9e-26 90.1 1.2 1.1 1 0 0 1 1 1 1 Flagellar and Swarming motility proteins Flg_bbr_C PF06429.13 ACT02081.1 - 7.5e-23 80.5 0.8 5.2e-22 77.8 0.2 2.6 3 0 0 3 3 3 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 ACT02081.1 - 9.1e-13 47.8 0.1 3.6e-12 45.9 0.1 2.1 1 0 0 1 1 1 1 Flagella basal body rod protein Flagellar_put PF12611.8 ACT02082.1 - 6.3e-14 51.4 3.6 6.3e-14 51.4 3.6 1.8 2 0 0 2 2 2 1 Putative flagellar DUF4258 PF14076.6 ACT02082.1 - 0.014 15.7 0.8 0.045 14.1 0.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4258) DUF1670 PF07900.11 ACT02082.1 - 0.044 13.1 0.1 0.051 12.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1670) YkuI_C PF10388.9 ACT02082.1 - 0.091 12.6 0.1 0.1 12.4 0.1 1.0 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain FlgD PF03963.14 ACT02083.1 - 1e-21 77.0 5.1 1e-21 77.0 5.1 2.0 2 0 0 2 2 2 1 Flagellar hook capping protein - N-terminal region S_100 PF01023.19 ACT02083.1 - 0.015 15.0 0.2 0.038 13.7 0.2 1.6 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain FLgD_tudor PF13861.6 ACT02083.1 - 0.03 14.6 0.2 0.16 12.3 0.2 2.1 1 1 0 1 1 1 0 FlgD Tudor-like domain Flg_hook PF02120.16 ACT02084.1 - 2.6e-21 75.3 1.3 2.6e-21 75.3 1.3 3.1 3 1 1 4 4 4 1 Flagellar hook-length control protein FliK HpaP PF09483.10 ACT02084.1 - 0.0093 16.2 0.5 0.033 14.4 0.0 2.1 2 0 0 2 2 2 1 Type III secretion protein (HpaP) Prominin PF05478.11 ACT02084.1 - 0.4 8.6 3.5 0.78 7.6 3.5 1.4 1 0 0 1 1 1 0 Prominin MgtE_N PF03448.17 ACT02085.1 - 3.2e-09 37.3 9.8 2.4e-06 28.1 2.4 3.3 1 1 0 2 2 2 2 MgtE intracellular N domain TMF_DNA_bd PF12329.8 ACT02085.1 - 0.00015 21.7 22.2 0.0041 17.1 0.6 3.2 2 1 1 3 3 3 2 TATA element modulatory factor 1 DNA binding Fez1 PF06818.15 ACT02085.1 - 0.00032 21.2 9.5 0.00047 20.7 9.5 1.3 1 0 0 1 1 1 1 Fez1 SlyX PF04102.12 ACT02085.1 - 0.0031 18.1 16.1 0.55 10.9 9.9 2.6 2 0 0 2 2 2 2 SlyX ATG16 PF08614.11 ACT02085.1 - 0.0039 17.4 17.5 0.0065 16.7 10.3 2.2 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) DUF4404 PF14357.6 ACT02085.1 - 0.005 17.5 6.1 0.005 17.5 6.1 2.8 3 0 0 3 3 2 1 Domain of unknown function (DUF4404) TMF_TATA_bd PF12325.8 ACT02085.1 - 0.0071 16.5 9.5 0.0071 16.5 9.5 2.3 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding APG6_N PF17675.1 ACT02085.1 - 0.017 15.6 14.6 0.019 15.5 9.2 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 ACT02085.1 - 0.019 15.0 10.3 0.019 15.0 10.3 2.2 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-Q PF13094.6 ACT02085.1 - 0.021 15.0 16.5 0.88 9.8 10.4 2.3 1 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit UPF0242 PF06785.11 ACT02085.1 - 0.048 13.8 6.1 0.022 14.9 2.7 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TMEM215 PF15746.5 ACT02085.1 - 0.052 13.0 4.0 0.058 12.9 2.3 1.8 1 1 1 2 2 2 0 TMEM215 family DUF724 PF05266.14 ACT02085.1 - 0.065 13.1 11.1 0.12 12.2 5.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Muted PF14942.6 ACT02085.1 - 0.082 13.3 11.5 0.098 13.0 6.3 2.2 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein PRKG1_interact PF15898.5 ACT02085.1 - 0.16 12.9 13.8 2 9.3 9.1 2.3 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Swi5 PF07061.11 ACT02085.1 - 0.21 11.7 17.2 0.18 11.9 8.7 2.9 2 1 0 2 2 2 0 Swi5 XhlA PF10779.9 ACT02085.1 - 0.37 11.0 7.0 1 9.6 6.2 2.2 1 1 0 1 1 1 0 Haemolysin XhlA HIP1_clath_bdg PF16515.5 ACT02085.1 - 0.39 11.4 15.9 0.61 10.7 9.1 2.6 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc7 PF08317.11 ACT02085.1 - 0.45 9.4 15.9 0.15 10.9 10.9 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Mod_r PF07200.13 ACT02085.1 - 0.63 10.1 16.2 0.21 11.7 10.0 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Med9 PF07544.13 ACT02085.1 - 0.64 10.1 9.3 0.63 10.2 5.7 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 V_ATPase_I PF01496.19 ACT02085.1 - 0.88 7.4 10.0 0.47 8.3 8.1 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DHR10 PF18595.1 ACT02085.1 - 1.1 9.3 21.4 0.16 12.0 15.5 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF1826 PF08856.11 ACT02085.1 - 1.3 8.9 5.7 0.45 10.4 2.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1826) BRE1 PF08647.11 ACT02085.1 - 1.7 8.8 21.4 0.76 9.9 3.6 3.4 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase USP8_interact PF08941.10 ACT02085.1 - 2.2 8.1 7.3 1.3 8.8 3.9 2.1 2 0 0 2 2 2 0 USP8 interacting FlxA PF14282.6 ACT02085.1 - 2.2 8.3 28.7 3.6 7.6 15.1 3.3 2 1 1 3 3 3 0 FlxA-like protein IF-2B PF01008.17 ACT02085.1 - 2.3 7.3 8.4 1.1 8.4 4.3 2.1 2 0 0 2 2 2 0 Initiation factor 2 subunit family AAA_13 PF13166.6 ACT02085.1 - 2.9 6.4 16.5 4 6.0 16.5 1.1 1 0 0 1 1 1 0 AAA domain DUF1690 PF07956.11 ACT02085.1 - 3.5 8.0 18.7 4.3 7.8 5.7 3.3 2 1 1 3 3 3 0 Protein of Unknown function (DUF1690) HrpB7 PF09486.10 ACT02085.1 - 3.9 7.8 18.9 1.8 8.9 8.8 2.4 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) FlaC_arch PF05377.11 ACT02085.1 - 4.7 7.7 8.3 41 4.7 5.1 3.1 3 1 1 4 4 2 0 Flagella accessory protein C (FlaC) LUC7 PF03194.15 ACT02085.1 - 6.1 6.4 15.8 2.1 8.0 10.1 2.0 1 1 0 2 2 2 0 LUC7 N_terminus GREB1 PF15782.5 ACT02085.1 - 6.2 3.8 11.9 7.3 3.6 11.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ADIP PF11559.8 ACT02085.1 - 7 6.7 17.8 2.6 8.1 11.4 2.4 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding PKcGMP_CC PF16808.5 ACT02085.1 - 7.4 6.5 13.5 0.17 11.8 0.6 3.7 5 0 0 5 5 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4795 PF16043.5 ACT02085.1 - 7.7 6.1 22.7 13 5.3 21.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Atg14 PF10186.9 ACT02085.1 - 8 5.4 19.7 41 3.1 19.6 1.9 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CASP_C PF08172.12 ACT02085.1 - 8.3 5.7 13.9 0.35 10.2 5.2 2.1 2 0 0 2 2 2 0 CASP C terminal TMCO5 PF14992.6 ACT02085.1 - 8.6 5.8 18.9 0.45 10.0 11.4 2.3 2 1 1 3 3 3 0 TMCO5 family DUF641 PF04859.12 ACT02085.1 - 8.8 6.7 16.5 7.8 6.8 0.9 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FliJ PF02050.16 ACT02086.1 - 1.7e-14 54.1 12.3 2.1e-14 53.8 12.3 1.1 1 0 0 1 1 1 1 Flagellar FliJ protein YscO-like PF16789.5 ACT02086.1 - 3.4e-05 23.9 13.8 0.00081 19.5 13.8 2.1 1 1 0 1 1 1 1 YscO-like protein DUF3347 PF11827.8 ACT02086.1 - 0.48 10.6 6.0 0.59 10.3 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) ATP-synt_ab PF00006.25 ACT02087.1 - 1.6e-75 253.4 0.0 2.2e-75 253.0 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain T3SS_ATPase_C PF18269.1 ACT02087.1 - 1.8e-25 88.6 1.0 2.8e-25 87.9 1.0 1.3 1 0 0 1 1 1 1 T3SS EscN ATPase C-terminal domain ATP-synt_ab_N PF02874.23 ACT02087.1 - 1.9e-08 34.7 0.1 5.5e-08 33.2 0.1 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ABC_tran PF00005.27 ACT02087.1 - 0.00021 21.8 0.3 0.00061 20.3 0.1 1.8 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 ACT02087.1 - 0.0046 16.9 0.3 0.01 15.8 0.3 1.5 1 0 0 1 1 1 1 RsgA GTPase DUF87 PF01935.17 ACT02087.1 - 0.11 12.6 0.2 0.11 12.6 0.2 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain FliH PF02108.16 ACT02088.1 - 2.1e-15 56.9 0.9 2.1e-15 56.9 0.9 1.8 2 0 0 2 2 2 1 Flagellar assembly protein FliH NolV PF06635.12 ACT02088.1 - 1.6e-05 24.4 3.1 2.4e-05 23.8 3.1 1.3 1 0 0 1 1 1 1 Nodulation protein NolV Yae1_N PF09811.9 ACT02088.1 - 0.068 12.9 1.3 0.14 11.9 1.3 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal DivIVA PF05103.13 ACT02088.1 - 9.2 6.4 16.0 0.59 10.2 4.7 2.8 2 1 1 3 3 3 0 DivIVA protein FliG_N PF14842.6 ACT02089.1 - 3.3e-48 162.5 13.1 2.7e-38 130.7 0.9 3.2 3 0 0 3 3 3 2 FliG N-terminal domain FliG_C PF01706.16 ACT02089.1 - 1.8e-47 160.0 18.2 1.8e-43 147.1 8.2 3.2 3 0 0 3 3 3 3 FliG C-terminal domain FliG_M PF14841.6 ACT02089.1 - 6.5e-34 116.0 15.7 3.9e-29 100.7 2.9 4.1 5 0 0 5 5 5 2 FliG middle domain MgtE_N PF03448.17 ACT02089.1 - 3.8e-07 30.7 13.5 0.12 13.0 1.3 5.0 1 1 4 5 5 5 5 MgtE intracellular N domain His_biosynth PF00977.21 ACT02089.1 - 0.00099 18.6 0.6 0.0022 17.5 0.6 1.6 1 0 0 1 1 1 1 Histidine biosynthesis protein TFA2_Winged_2 PF18121.1 ACT02089.1 - 0.022 14.4 0.0 0.093 12.4 0.0 2.1 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 TRAF_BIRC3_bd PF16673.5 ACT02089.1 - 4.4 7.2 13.8 0.11 12.3 1.3 3.4 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain YscJ_FliF PF01514.17 ACT02090.1 - 1e-54 185.1 0.8 3e-54 183.6 0.1 2.2 2 0 0 2 2 2 1 Secretory protein of YscJ/FliF family YscJ_FliF_C PF08345.11 ACT02090.1 - 5.3e-18 65.8 6.5 8.7e-18 65.1 5.4 1.9 2 0 0 2 2 2 1 Flagellar M-ring protein C-terminal EC042_2821 PF18740.1 ACT02090.1 - 0.093 12.6 0.6 0.33 10.8 0.3 2.0 2 0 0 2 2 2 0 EC042_2821-lke REase CcmD PF04995.14 ACT02090.1 - 0.1 12.7 4.1 0.35 11.0 4.1 1.9 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) DUF4367 PF14285.6 ACT02090.1 - 0.25 11.8 3.1 8.7 6.8 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4367) FlxA PF14282.6 ACT02090.1 - 1.3 9.1 11.3 0.12 12.4 2.6 3.0 3 0 0 3 3 3 0 FlxA-like protein FliE PF02049.18 ACT02091.1 - 2.4e-27 94.9 2.8 2.9e-27 94.6 2.8 1.1 1 0 0 1 1 1 1 Flagellar hook-basal body complex protein FliE Rep_2 PF01719.17 ACT02091.1 - 0.023 14.5 0.2 0.026 14.3 0.2 1.0 1 0 0 1 1 1 0 Plasmid replication protein Flg_bbr_C PF06429.13 ACT02092.1 - 4.6e-13 49.1 0.9 9.5e-13 48.1 0.1 1.9 2 0 0 2 2 2 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 ACT02092.1 - 1.1e-09 38.0 1.0 1.1e-09 38.0 1.0 1.9 2 0 0 2 2 2 1 Flagella basal body rod protein Flg_bb_rod PF00460.20 ACT02093.1 - 2e-08 34.0 0.1 2e-08 34.0 0.1 2.2 3 0 0 3 3 3 1 Flagella basal body rod protein Flg_bbr_C PF06429.13 ACT02093.1 - 0.0013 18.8 0.7 0.0025 17.9 0.7 1.6 1 0 0 1 1 1 1 Flagellar basal body rod FlgEFG protein C-terminal CodY PF06018.14 ACT02094.1 - 9.4e-52 175.0 0.0 1.2e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 CodY GAF-like domain HTH_CodY PF08222.11 ACT02094.1 - 6.5e-36 121.7 1.9 1.1e-35 120.9 1.9 1.4 1 0 0 1 1 1 1 CodY helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT02094.1 - 3.2e-06 27.0 2.4 5.2e-06 26.3 0.3 2.3 2 1 0 2 2 2 1 Crp-like helix-turn-helix domain MarR_2 PF12802.7 ACT02094.1 - 1.6e-05 24.7 0.5 4.1e-05 23.4 0.1 1.9 2 0 0 2 2 2 1 MarR family HTH_11 PF08279.12 ACT02094.1 - 2.5e-05 24.1 0.7 6.3e-05 22.8 0.1 1.9 2 0 0 2 2 2 1 HTH domain HTH_20 PF12840.7 ACT02094.1 - 0.00042 20.3 0.0 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 ACT02094.1 - 0.00046 20.0 0.1 0.001 18.9 0.1 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB GntR PF00392.21 ACT02094.1 - 0.00063 19.3 0.1 0.0015 18.1 0.1 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Rrf2 PF02082.20 ACT02094.1 - 0.0008 19.7 0.3 0.0022 18.3 0.1 1.9 2 0 0 2 2 2 1 Transcriptional regulator HTH_5 PF01022.20 ACT02094.1 - 0.0011 18.8 0.1 0.02 14.7 0.0 2.3 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 ACT02094.1 - 0.0013 18.2 0.1 0.0034 16.9 0.1 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_41 PF14502.6 ACT02094.1 - 0.0025 17.5 0.1 0.0065 16.1 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 ACT02094.1 - 0.003 17.5 2.2 0.003 17.5 0.0 2.1 3 0 0 3 3 3 1 MarR family GAF PF01590.26 ACT02094.1 - 0.011 16.4 0.0 0.023 15.3 0.0 1.8 1 1 0 1 1 1 0 GAF domain GAF_2 PF13185.6 ACT02094.1 - 0.015 15.6 0.0 0.034 14.4 0.0 1.8 1 1 0 1 1 1 0 GAF domain HTH_46 PF15977.5 ACT02094.1 - 0.043 13.8 0.3 0.21 11.6 0.2 2.1 1 1 1 2 2 2 0 Winged helix-turn-helix DNA binding Ribosomal_S25 PF03297.15 ACT02094.1 - 0.047 13.9 0.1 0.089 13.0 0.1 1.5 1 0 0 1 1 1 0 S25 ribosomal protein GAF_3 PF13492.6 ACT02094.1 - 0.068 13.5 0.0 0.23 11.8 0.0 2.0 1 1 1 2 2 2 0 GAF domain AAA_2 PF07724.14 ACT02095.1 - 2.9e-49 167.5 0.4 7.7e-40 136.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 ACT02095.1 - 1.1e-15 58.2 0.2 1.2e-06 29.0 0.1 2.9 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 ACT02095.1 - 4.3e-08 33.1 0.8 1.2e-07 31.6 0.1 2.2 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 ACT02095.1 - 1.4e-07 31.6 0.1 1.6e-05 24.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ACT02095.1 - 5.4e-06 26.7 0.2 0.00049 20.4 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 ACT02095.1 - 1.3e-05 25.7 0.9 0.00022 21.6 0.2 2.6 2 1 0 2 2 2 1 AAA ATPase domain MCM PF00493.23 ACT02095.1 - 1.9e-05 23.9 0.2 0.00075 18.7 0.1 2.2 2 0 0 2 2 2 1 MCM P-loop domain Mg_chelatase PF01078.21 ACT02095.1 - 3.4e-05 23.3 1.3 0.0025 17.2 0.0 3.6 4 1 1 5 5 4 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 ACT02095.1 - 0.00038 20.2 0.8 0.11 12.3 0.0 2.9 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 ACT02095.1 - 0.0019 18.5 0.2 0.0073 16.6 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ACT02095.1 - 0.002 18.6 0.2 0.007 16.9 0.0 2.1 2 1 0 2 2 1 1 AAA domain TniB PF05621.11 ACT02095.1 - 0.0021 17.5 0.4 0.038 13.4 0.1 2.4 2 0 0 2 2 2 1 Bacterial TniB protein NTPase_1 PF03266.15 ACT02095.1 - 0.0023 17.8 1.0 0.65 9.9 0.1 2.5 2 0 0 2 2 2 1 NTPase Sigma54_activat PF00158.26 ACT02095.1 - 0.0028 17.4 0.0 0.059 13.1 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain Thiolase_N PF00108.23 ACT02095.1 - 0.0038 16.6 0.6 0.016 14.5 0.5 2.0 3 0 0 3 3 3 1 Thiolase, N-terminal domain AAA_33 PF13671.6 ACT02095.1 - 0.017 15.3 0.1 0.036 14.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 ACT02095.1 - 0.03 13.9 0.1 0.082 12.5 0.1 1.8 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain IstB_IS21 PF01695.17 ACT02095.1 - 0.039 13.7 0.0 0.1 12.4 0.0 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 ACT02095.1 - 0.041 13.4 0.2 0.12 11.8 0.0 1.9 2 0 0 2 2 1 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 ACT02095.1 - 0.049 12.9 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 ACT02095.1 - 0.066 12.9 0.2 0.23 11.1 0.1 1.9 2 1 0 2 2 2 0 AAA domain DEAD PF00270.29 ACT02095.1 - 0.067 13.0 1.1 1.1 9.0 0.5 2.7 2 1 1 3 3 3 0 DEAD/DEAH box helicase TsaE PF02367.17 ACT02095.1 - 0.097 12.7 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ACT02095.1 - 0.12 12.9 0.5 0.44 11.0 0.5 1.9 1 1 0 1 1 1 0 ABC transporter ATP-synt_ab PF00006.25 ACT02095.1 - 0.14 11.8 0.1 0.33 10.6 0.1 1.6 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF1818 PF08848.11 ACT02095.1 - 0.15 12.1 0.6 0.94 9.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1818) NACHT PF05729.12 ACT02095.1 - 0.17 11.8 0.2 1.6 8.6 0.0 2.6 3 0 0 3 3 3 0 NACHT domain ResIII PF04851.15 ACT02095.1 - 0.73 9.8 4.0 1.9 8.5 0.0 2.7 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ACT02095.1 - 1.2 9.4 3.5 4.1 7.7 3.5 2.0 1 1 0 1 1 1 0 AAA domain Proteasome PF00227.26 ACT02096.1 - 4.2e-25 88.3 0.5 7e-25 87.6 0.5 1.3 1 1 0 1 1 1 1 Proteasome subunit MCR_alpha PF02249.17 ACT02096.1 - 0.075 13.5 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain GIDA PF01134.22 ACT02097.1 - 7.5e-112 374.3 0.0 9.1e-112 374.0 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 ACT02097.1 - 0.00011 21.9 0.2 0.0034 17.0 0.1 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ACT02097.1 - 0.00023 20.5 0.0 0.00044 19.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ACT02097.1 - 0.00029 20.2 0.1 0.0029 16.9 0.0 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 ACT02097.1 - 0.00067 19.8 0.0 0.0037 17.4 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ACT02097.1 - 0.0019 17.3 0.0 0.0034 16.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain 3HCDH_N PF02737.18 ACT02097.1 - 0.0065 16.4 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 ACT02097.1 - 0.022 13.5 0.0 0.18 10.5 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 ACT02097.1 - 0.023 14.0 0.0 0.32 10.2 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ACT02097.1 - 0.052 12.9 0.0 0.16 11.3 0.1 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ACT02097.1 - 0.14 11.3 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Topoisom_bac PF01131.20 ACT02098.1 - 7.7e-135 450.1 0.1 1e-134 449.6 0.1 1.2 1 0 0 1 1 1 1 DNA topoisomerase zf-C4_Topoisom PF01396.19 ACT02098.1 - 2.4e-33 113.6 19.6 1.3e-15 56.9 2.1 3.5 3 0 0 3 3 3 3 Topoisomerase DNA binding C4 zinc finger Toprim PF01751.22 ACT02098.1 - 1.5e-29 102.3 0.0 3.3e-29 101.1 0.0 1.6 1 0 0 1 1 1 1 Toprim domain RNA_POL_M_15KD PF02150.16 ACT02098.1 - 3.5e-06 26.8 16.7 0.0002 21.2 4.0 3.5 3 0 0 3 3 3 2 RNA polymerases M/15 Kd subunit Toprim_4 PF13662.6 ACT02098.1 - 0.0016 18.8 0.0 0.006 17.0 0.0 2.0 1 1 0 1 1 1 1 Toprim domain zf-ribbon_3 PF13248.6 ACT02098.1 - 0.025 14.0 10.9 2.9 7.4 0.1 4.2 4 0 0 4 4 4 0 zinc-ribbon domain Auto_anti-p27 PF06677.12 ACT02098.1 - 0.028 14.6 2.8 0.028 14.6 2.8 3.2 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 ACT02098.1 - 0.096 12.7 9.5 3 7.9 0.3 2.6 2 1 0 2 2 2 0 Double zinc ribbon Rpr2 PF04032.16 ACT02098.1 - 0.85 9.9 5.6 1.1 9.5 0.5 2.7 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain OrfB_Zn_ribbon PF07282.11 ACT02098.1 - 1 9.3 14.0 0.098 12.6 1.8 3.3 2 1 1 3 3 3 0 Putative transposase DNA-binding domain Lar_restr_allev PF14354.6 ACT02098.1 - 1.4 9.4 14.7 0.19 12.1 1.6 3.0 3 0 0 3 3 3 0 Restriction alleviation protein Lar GFA PF04828.14 ACT02098.1 - 2.2 8.7 5.4 4 7.8 0.1 3.2 2 1 0 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme Anti-TRAP PF15777.5 ACT02098.1 - 4.9 7.2 8.6 5.7 7.0 1.9 2.8 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Opy2 PF09463.10 ACT02098.1 - 5 7.5 7.4 67 3.9 0.1 3.7 3 0 0 3 3 3 0 Opy2 protein zf_Rg PF17915.1 ACT02098.1 - 6 6.3 11.7 22 4.5 0.4 3.2 2 1 0 2 2 2 0 Reverse gyrase zinc finger zinc_ribbon_9 PF14369.6 ACT02098.1 - 9 6.6 11.7 11 6.3 0.2 4.0 3 1 1 4 4 4 0 zinc-ribbon DNA_ligase_ZBD PF03119.16 ACT02098.1 - 9.7 6.3 9.7 1.9 8.6 1.7 2.8 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain DNA_processg_A PF02481.15 ACT02099.1 - 9.7e-80 266.7 0.0 1.3e-79 266.3 0.0 1.2 1 0 0 1 1 1 1 DNA recombination-mediator protein A DprA_WH PF17782.1 ACT02099.1 - 1.8e-08 34.4 0.0 3.5e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 DprA winged helix domain LDcluster4 PF18306.1 ACT02099.1 - 0.032 13.8 0.1 0.055 13.0 0.1 1.5 1 1 0 1 1 1 0 SLOG cluster4 family DUF742 PF05331.11 ACT02099.1 - 0.04 13.7 0.1 0.08 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF742) EHN PF06441.12 ACT02099.1 - 0.084 13.3 0.3 0.2 12.1 0.3 1.5 1 0 0 1 1 1 0 Epoxide hydrolase N terminus CoA_binding PF02629.19 ACT02100.1 - 1.9e-25 89.3 2.1 1.9e-25 89.3 2.1 2.3 2 1 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 ACT02100.1 - 2.7e-17 63.0 0.2 4.3e-17 62.4 0.2 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 ACT02100.1 - 3e-08 33.6 0.0 4.8e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 ACT02100.1 - 0.032 14.7 0.1 0.091 13.3 0.1 1.8 2 0 0 2 2 2 0 CoA binding domain ATP-grasp_2 PF08442.10 ACT02101.1 - 1.3e-79 266.4 5.9 1.3e-79 266.4 5.9 1.5 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 ACT02101.1 - 2e-25 89.4 1.1 3.9e-25 88.5 1.1 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 ACT02101.1 - 4e-16 59.2 4.6 9.7e-16 57.9 4.6 1.6 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 ACT02101.1 - 2.1e-05 24.4 0.5 4.8e-05 23.2 0.5 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain CPSase_L_D2 PF02786.17 ACT02101.1 - 5.4e-05 22.8 0.8 9.9e-05 21.9 0.8 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 ACT02101.1 - 0.023 14.3 0.4 0.038 13.5 0.4 1.4 1 1 0 1 1 1 0 ATP-grasp domain Mg_chelatase PF01078.21 ACT02102.1 - 1.2e-87 292.7 0.0 2.4e-87 291.6 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ChlI PF13541.6 ACT02102.1 - 1.4e-46 157.3 0.1 3.1e-46 156.2 0.1 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase Mg_chelatase_C PF13335.6 ACT02102.1 - 7.8e-23 80.9 2.2 1.8e-22 79.8 2.2 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI C-terminal MCM PF00493.23 ACT02102.1 - 1.1e-06 27.9 0.0 0.00027 20.1 0.0 2.4 2 0 0 2 2 2 1 MCM P-loop domain Lon_C PF05362.13 ACT02102.1 - 9.3e-06 25.3 0.1 1.6e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA_5 PF07728.14 ACT02102.1 - 1.2e-05 25.4 0.0 0.00022 21.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_32 PF13654.6 ACT02102.1 - 0.00028 19.8 0.1 0.19 10.5 0.0 2.2 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 ACT02102.1 - 0.0004 20.1 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain RuvB_N PF05496.12 ACT02102.1 - 0.0011 18.7 0.0 2.5 7.8 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 ACT02102.1 - 0.0035 17.8 0.2 0.016 15.7 0.1 2.2 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) MCM_lid PF17855.1 ACT02102.1 - 0.0051 17.2 0.1 0.028 14.8 0.2 2.2 2 0 0 2 2 2 1 MCM AAA-lid domain AAA_30 PF13604.6 ACT02102.1 - 0.0056 16.4 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ACT02102.1 - 0.012 15.1 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_2 PF07724.14 ACT02102.1 - 0.013 15.6 0.0 0.098 12.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ACT02102.1 - 0.015 15.6 0.2 0.054 13.9 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 ACT02102.1 - 0.016 15.5 0.0 0.037 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_lid_2 PF17863.1 ACT02102.1 - 0.024 14.4 0.9 0.062 13.2 0.2 2.0 2 0 0 2 2 2 0 AAA lid domain T2SSE PF00437.20 ACT02102.1 - 0.025 13.6 0.0 0.047 12.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_11 PF13086.6 ACT02102.1 - 0.028 14.2 0.0 0.049 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ACT02102.1 - 0.035 14.4 0.1 0.15 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 ACT02102.1 - 0.11 12.5 0.0 0.25 11.2 0.0 1.6 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_33 PF13671.6 ACT02102.1 - 0.14 12.4 0.2 0.65 10.1 0.0 2.2 3 0 0 3 3 3 0 AAA domain ResIII PF04851.15 ACT02102.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_24 PF13479.6 ACT02102.1 - 0.18 11.5 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain UPF0102 PF02021.17 ACT02103.1 - 1.3e-31 108.6 0.2 1.7e-31 108.2 0.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0102 NERD PF08378.11 ACT02103.1 - 1.3e-05 25.6 0.0 2.1e-05 24.9 0.0 1.3 1 1 1 2 2 2 1 Nuclease-related domain Mrr_cat PF04471.12 ACT02103.1 - 0.012 15.6 0.1 0.021 14.8 0.1 1.4 1 1 0 1 1 1 0 Restriction endonuclease NucS PF01939.16 ACT02103.1 - 0.013 14.8 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Endonuclease NucS Bac_export_2 PF01312.19 ACT02104.1 - 4.5e-20 72.1 0.4 5.5e-20 71.8 0.4 1.0 1 0 0 1 1 1 1 FlhB HrpN YscU SpaS Family Flg_hook PF02120.16 ACT02105.1 - 2.3e-06 27.4 0.0 2.3e-06 27.4 0.0 3.4 4 0 0 4 4 4 1 Flagellar hook-length control protein FliK DUF4269 PF14091.6 ACT02106.1 - 3.6e-57 192.9 0.0 4e-57 192.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4269) RNase_HII PF01351.18 ACT02107.1 - 6.8e-36 124.0 0.1 8e-36 123.7 0.1 1.0 1 0 0 1 1 1 1 Ribonuclease HII MMR_HSR1 PF01926.23 ACT02108.1 - 1.5e-16 60.4 0.0 1.5e-15 57.3 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ACT02108.1 - 9.5e-08 31.7 0.0 4.1e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ACT02108.1 - 6.5e-06 26.2 0.1 0.00022 21.2 0.1 2.4 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 ACT02108.1 - 0.00083 19.5 0.1 0.024 14.7 0.0 2.4 1 1 0 2 2 2 1 Dynamin family Arf PF00025.21 ACT02108.1 - 0.0063 16.0 0.1 0.31 10.5 0.0 2.6 1 1 2 3 3 3 1 ADP-ribosylation factor family AAA_18 PF13238.6 ACT02108.1 - 0.015 15.8 0.0 0.031 14.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 ACT02108.1 - 0.074 12.0 0.1 0.15 11.0 0.1 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 ACT02108.1 - 0.095 12.3 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 ACT02108.1 - 0.1 12.1 0.1 11 5.5 0.0 2.5 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 ACT02108.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Peptidase_S24 PF00717.23 ACT02109.1 - 2e-18 66.1 1.3 3.8e-18 65.2 1.3 1.6 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 ACT02109.1 - 3.7e-10 39.7 0.5 2.6e-09 37.0 0.5 2.2 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 Ribosomal_L19 PF01245.20 ACT02110.1 - 5e-54 181.0 1.5 5.5e-54 180.8 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L19 C1q PF00386.21 ACT02111.1 - 5.6e-10 39.5 0.4 6.7e-10 39.3 0.4 1.1 1 0 0 1 1 1 1 C1q domain BclA_C PF18573.1 ACT02111.1 - 0.0048 16.8 4.4 0.0065 16.4 4.4 1.1 1 0 0 1 1 1 1 BclA C-terminal domain C1q PF00386.21 ACT02112.1 - 6.3e-06 26.4 0.0 7.6e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 C1q domain PDZ_2 PF13180.6 ACT02112.1 - 0.06 13.7 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 PDZ domain tRNA_m1G_MT PF01746.21 ACT02113.1 - 1e-73 247.2 0.0 1.2e-73 247.0 0.0 1.0 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase RimM PF01782.18 ACT02114.1 - 5.4e-24 84.2 0.1 8.4e-24 83.6 0.1 1.3 1 0 0 1 1 1 1 RimM N-terminal domain PRC PF05239.16 ACT02114.1 - 4.8e-13 49.0 0.7 4.8e-13 49.0 0.7 1.7 3 0 0 3 3 3 1 PRC-barrel domain KH_4 PF13083.6 ACT02115.1 - 1.3e-22 79.5 2.1 1.4e-22 79.3 2.1 1.0 1 0 0 1 1 1 1 KH domain KH_1 PF00013.29 ACT02115.1 - 0.00056 19.7 0.2 0.00083 19.1 0.2 1.4 1 0 0 1 1 1 1 KH domain DUF2969 PF11184.8 ACT02115.1 - 0.024 15.0 0.3 0.029 14.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2969) Ribosomal_S16 PF00886.19 ACT02116.1 - 2.1e-24 85.3 0.0 2.6e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S16 SRP54 PF00448.22 ACT02117.1 - 5.8e-79 264.3 0.4 9.7e-79 263.6 0.4 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 ACT02117.1 - 5.8e-34 116.7 6.5 5.8e-34 116.7 6.5 2.7 3 0 0 3 3 2 1 Signal peptide binding domain SRP54_N PF02881.19 ACT02117.1 - 1.4e-21 76.4 2.3 1.4e-21 76.4 2.3 2.8 3 0 0 3 3 2 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 ACT02117.1 - 1.7e-07 31.3 0.4 7e-07 29.3 0.1 2.1 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain Zeta_toxin PF06414.12 ACT02117.1 - 9.1e-05 21.8 0.2 0.00026 20.3 0.1 1.9 1 1 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 ACT02117.1 - 0.00028 21.0 0.2 0.00075 19.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 ACT02117.1 - 0.00045 20.5 0.0 0.0015 18.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.18 ACT02117.1 - 0.0014 18.0 0.0 0.0036 16.6 0.0 1.6 1 0 0 1 1 1 1 6-phosphofructo-2-kinase cobW PF02492.19 ACT02117.1 - 0.0023 17.5 3.1 0.019 14.6 3.1 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain Mlf1IP PF10248.9 ACT02117.1 - 0.0028 17.7 4.7 0.0042 17.1 3.8 1.7 1 1 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein APS_kinase PF01583.20 ACT02117.1 - 0.0036 17.2 0.1 0.11 12.4 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_17 PF13207.6 ACT02117.1 - 0.0043 17.5 0.1 0.0043 17.5 0.1 3.0 3 2 0 3 3 2 1 AAA domain AAA_30 PF13604.6 ACT02117.1 - 0.0048 16.6 1.6 0.0071 16.1 0.4 1.9 2 0 0 2 2 2 1 AAA domain AAA_31 PF13614.6 ACT02117.1 - 0.0052 16.7 4.6 0.0061 16.5 0.3 3.0 3 1 0 3 3 3 1 AAA domain ArsA_ATPase PF02374.15 ACT02117.1 - 0.0078 15.4 7.2 0.39 9.9 0.1 3.4 3 1 0 3 3 3 1 Anion-transporting ATPase ParA PF10609.9 ACT02117.1 - 0.008 15.7 0.1 0.024 14.1 0.1 1.9 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase MMR_HSR1 PF01926.23 ACT02117.1 - 0.012 15.7 4.3 0.021 14.9 0.9 2.9 3 1 0 3 3 3 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ACT02117.1 - 0.013 15.2 1.4 2.2 8.0 0.0 2.8 2 1 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 ACT02117.1 - 0.03 14.7 0.0 0.08 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 ACT02117.1 - 0.032 14.0 0.1 0.62 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ACT02117.1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 ACT02117.1 - 0.085 12.3 1.2 0.34 10.3 1.2 2.0 1 1 0 1 1 1 0 ADP-ribosylation factor family AAA_18 PF13238.6 ACT02117.1 - 0.086 13.4 0.3 0.32 11.6 0.3 2.1 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 ACT02117.1 - 0.1 12.0 2.4 3 7.2 0.0 2.4 2 0 0 2 2 2 0 Chromatin associated protein KTI12 NACHT PF05729.12 ACT02117.1 - 0.1 12.5 0.7 0.32 10.9 0.6 1.9 1 1 0 1 1 1 0 NACHT domain Thymidylate_kin PF02223.17 ACT02117.1 - 0.13 12.0 0.7 0.54 9.9 0.2 2.3 2 0 0 2 2 1 0 Thymidylate kinase ResIII PF04851.15 ACT02117.1 - 0.26 11.3 4.9 0.45 10.5 2.1 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 ACT02117.1 - 0.27 11.7 2.1 0.5 10.9 0.2 2.4 2 1 0 2 2 2 0 ABC transporter DUF1133 PF06576.11 ACT02117.1 - 0.37 10.2 2.5 4.8 6.5 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1133) TsaE PF02367.17 ACT02117.1 - 1.2 9.1 3.6 0.69 9.9 0.6 2.2 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF4175 PF13779.6 ACT02117.1 - 2.4 6.0 15.9 1.5 6.7 12.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) AAA_25 PF13481.6 ACT02117.1 - 5.5 6.5 8.5 37 3.8 1.9 3.9 3 1 1 4 4 4 0 AAA domain UPF0122 PF04297.14 ACT02118.1 - 1.3e-29 102.4 0.7 1.7e-29 102.0 0.6 1.3 1 1 0 1 1 1 1 Putative helix-turn-helix protein, YlxM / p13 like Sigma70_r4 PF04545.16 ACT02118.1 - 5e-07 29.1 0.1 9.1e-07 28.3 0.1 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_10 PF04967.12 ACT02118.1 - 3.9e-06 26.6 0.5 8e-05 22.4 0.5 2.4 1 1 0 1 1 1 1 HTH DNA binding domain Sigma70_r4_2 PF08281.12 ACT02118.1 - 2.5e-05 23.8 0.0 5e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_28 PF13518.6 ACT02118.1 - 0.00011 22.3 0.1 0.00018 21.5 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_30 PF13556.6 ACT02118.1 - 0.00017 21.3 0.1 0.0023 17.7 0.0 2.2 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_40 PF14493.6 ACT02118.1 - 0.00046 20.6 0.1 0.00069 20.0 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Mga PF05043.13 ACT02118.1 - 0.00051 20.6 0.1 0.00081 19.9 0.1 1.4 1 0 0 1 1 1 1 Mga helix-turn-helix domain HTH_24 PF13412.6 ACT02118.1 - 0.001 18.6 0.0 0.0019 17.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 ACT02118.1 - 0.0056 16.6 0.1 0.019 14.9 0.0 1.9 2 0 0 2 2 2 1 HTH domain GcrA PF07750.11 ACT02118.1 - 0.0069 16.8 0.0 0.0098 16.3 0.0 1.3 1 0 0 1 1 1 1 GcrA cell cycle regulator Phage_antitermQ PF06530.12 ACT02118.1 - 0.0085 16.0 0.1 0.014 15.3 0.1 1.4 1 0 0 1 1 1 1 Phage antitermination protein Q Terminase_5 PF06056.12 ACT02118.1 - 0.0096 15.8 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) HTH_Tnp_1_2 PF13022.6 ACT02118.1 - 0.01 16.0 0.1 0.027 14.6 0.1 1.7 1 1 1 2 2 2 0 Helix-turn-helix of insertion element transposase HTH_23 PF13384.6 ACT02118.1 - 0.011 15.6 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain MarR_2 PF12802.7 ACT02118.1 - 0.011 15.6 0.0 0.03 14.2 0.0 1.7 2 0 0 2 2 2 0 MarR family TetR_N PF00440.23 ACT02118.1 - 0.023 14.5 0.1 0.054 13.3 0.1 1.7 1 1 0 1 1 1 0 Bacterial regulatory proteins, tetR family GerE PF00196.19 ACT02118.1 - 0.026 14.1 0.0 0.08 12.5 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Oxidored_nitro PF00148.19 ACT02118.1 - 0.053 12.3 0.0 0.055 12.2 0.0 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase HTH_29 PF13551.6 ACT02118.1 - 0.072 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix DUF2841 PF11001.8 ACT02118.1 - 0.13 12.3 0.1 0.66 10.0 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2841) SRP54 PF00448.22 ACT02119.1 - 3.4e-80 268.3 2.0 3.4e-80 268.3 2.0 1.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 ACT02119.1 - 6.3e-14 52.0 4.6 6.3e-14 52.0 4.6 1.9 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain AAA_30 PF13604.6 ACT02119.1 - 1.1e-05 25.3 0.1 1.9e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT02119.1 - 2.5e-05 24.7 0.5 8.1e-05 23.1 0.1 2.0 3 0 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 ACT02119.1 - 0.00011 22.5 0.9 0.0012 19.2 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 ACT02119.1 - 0.00045 20.7 1.0 0.0017 18.8 0.1 2.3 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 ACT02119.1 - 0.0013 18.8 1.2 0.054 13.6 0.1 2.5 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 ACT02119.1 - 0.0022 18.4 4.4 0.005 17.3 0.2 2.9 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ACT02119.1 - 0.0035 17.9 0.0 0.0067 16.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter Zeta_toxin PF06414.12 ACT02119.1 - 0.0038 16.5 0.1 0.0068 15.7 0.1 1.3 1 0 0 1 1 1 1 Zeta toxin MMR_HSR1 PF01926.23 ACT02119.1 - 0.0039 17.3 0.5 0.031 14.3 0.5 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF2075 PF09848.9 ACT02119.1 - 0.0046 16.3 0.0 0.0078 15.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 ACT02119.1 - 0.005 17.0 0.1 0.0096 16.1 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ACT02119.1 - 0.0056 16.7 0.2 0.076 13.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain MeaB PF03308.16 ACT02119.1 - 0.0076 15.3 1.2 0.043 12.8 1.6 2.1 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 ACT02119.1 - 0.0077 16.1 0.1 0.018 15.0 0.1 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_31 PF13614.6 ACT02119.1 - 0.0089 16.0 0.5 0.021 14.8 0.5 1.8 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 ACT02119.1 - 0.022 14.4 1.9 0.034 13.8 0.1 2.2 3 0 0 3 3 3 0 Thymidylate kinase NACHT PF05729.12 ACT02119.1 - 0.027 14.4 0.6 0.47 10.3 0.3 2.5 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 ACT02119.1 - 0.087 12.3 0.2 0.17 11.4 0.2 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Bac_DnaA PF00308.18 ACT02119.1 - 0.091 12.6 4.3 5.3 6.8 0.0 3.2 3 1 0 3 3 3 0 Bacterial dnaA protein KdpD PF02702.17 ACT02119.1 - 0.099 12.1 3.8 0.36 10.3 0.5 2.8 2 1 0 2 2 2 0 Osmosensitive K+ channel His kinase sensor domain AAA_5 PF07728.14 ACT02119.1 - 0.12 12.4 0.9 0.31 11.0 0.1 2.2 2 2 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ACT02119.1 - 0.12 12.1 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ACT02119.1 - 0.14 12.7 0.9 0.34 11.4 0.2 2.1 2 1 0 2 2 2 0 AAA domain ArsA_ATPase PF02374.15 ACT02119.1 - 0.17 11.0 4.3 0.072 12.3 0.5 2.2 3 0 0 3 3 3 0 Anion-transporting ATPase cobW PF02492.19 ACT02119.1 - 0.21 11.2 3.0 0.4 10.3 0.3 2.4 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 ACT02119.1 - 0.25 11.6 3.6 0.79 10.0 0.3 2.8 2 1 1 3 3 3 0 AAA domain MobB PF03205.14 ACT02119.1 - 0.32 10.9 2.7 0.31 10.9 0.3 2.2 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 ACT02119.1 - 0.56 10.1 6.7 0.16 11.8 0.8 2.7 2 2 1 3 3 3 0 NTPase SMC_N PF02463.19 ACT02120.1 - 1.2e-76 257.0 0.0 4.3e-76 255.2 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ACT02120.1 - 2e-34 118.4 0.1 6.5e-34 116.7 0.1 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ACT02120.1 - 7e-16 58.9 1.9 6.9e-07 29.4 0.1 3.1 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ACT02120.1 - 1.4e-14 54.6 22.0 1.7e-12 47.8 1.6 4.2 2 2 0 3 3 3 2 AAA ATPase domain AAA_23 PF13476.6 ACT02120.1 - 5.4e-12 46.6 26.8 5.4e-12 46.6 26.8 6.7 2 2 2 4 4 4 1 AAA domain AAA_29 PF13555.6 ACT02120.1 - 4.5e-05 23.1 0.0 9.2e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 ACT02120.1 - 0.012 15.9 0.0 0.067 13.4 0.0 2.4 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF5088 PF17008.5 ACT02120.1 - 0.012 15.4 0.5 0.024 14.4 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5088) Sirohm_synth_C PF14823.6 ACT02120.1 - 9.4 6.0 8.7 2.5 7.8 1.0 3.4 3 0 0 3 3 3 0 Sirohaem biosynthesis protein C-terminal Ribonucleas_3_3 PF14622.6 ACT02121.1 - 5.2e-39 133.3 0.0 9.3e-39 132.5 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 ACT02121.1 - 3.7e-22 78.9 0.0 6.2e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 ACT02121.1 - 9e-17 61.6 0.0 1.8e-16 60.6 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 ACT02121.1 - 0.0014 18.8 0.0 0.0032 17.7 0.0 1.6 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 ketoacyl-synt PF00109.26 ACT02122.1 - 3e-64 217.0 1.6 7e-63 212.5 0.5 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ACT02122.1 - 1.3e-37 128.4 2.2 1.3e-37 128.4 0.7 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 ACT02122.1 - 0.00098 18.6 1.3 0.0093 15.3 1.3 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 ACT02122.1 - 0.082 13.4 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 ACT02123.1 - 2.7e-17 62.9 1.9 3e-17 62.7 1.9 1.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 ACT02123.1 - 0.00011 22.3 3.3 0.00012 22.2 3.2 1.2 1 1 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.12 ACT02123.1 - 0.026 15.0 0.3 0.026 15.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) Ribosomal_L12_N PF16320.5 ACT02123.1 - 0.3 10.8 2.6 0.55 10.0 1.0 2.1 2 1 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain adh_short_C2 PF13561.6 ACT02124.1 - 2.2e-73 246.7 8.8 2.5e-73 246.5 8.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT02124.1 - 1e-63 214.4 6.6 1.2e-63 214.1 6.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT02124.1 - 2.5e-22 79.7 1.9 4.5e-22 78.8 1.4 1.6 1 1 1 2 2 2 1 KR domain THF_DHG_CYH_C PF02882.19 ACT02124.1 - 0.00012 21.4 0.8 0.00021 20.6 0.6 1.7 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 ACT02124.1 - 0.00044 19.8 0.8 0.0007 19.1 0.8 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 ACT02124.1 - 0.078 12.8 0.8 0.23 11.2 0.8 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase 3HCDH_N PF02737.18 ACT02124.1 - 0.17 11.8 2.3 1.7 8.5 0.5 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Acyl_transf_1 PF00698.21 ACT02125.1 - 7.8e-47 160.3 2.2 9.4e-47 160.1 2.2 1.0 1 0 0 1 1 1 1 Acyl transferase domain ACP_syn_III_C PF08541.10 ACT02126.1 - 1.5e-37 127.7 0.4 3.7e-36 123.2 0.0 2.7 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 ACT02126.1 - 5.7e-33 112.6 0.6 1e-32 111.8 0.6 1.4 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 ACT02126.1 - 1.6e-09 37.5 1.0 4.2e-09 36.1 0.6 2.0 1 1 1 2 2 2 1 Thiolase, N-terminal domain Chal_sti_synt_N PF00195.19 ACT02126.1 - 5.7e-06 25.9 0.4 7.9e-05 22.2 0.2 2.2 2 0 0 2 2 2 1 Chalcone and stilbene synthases, N-terminal domain SpoVAD PF07451.11 ACT02126.1 - 9.8e-06 24.5 1.7 0.0076 15.0 0.2 2.4 2 1 0 2 2 2 2 Stage V sporulation protein AD (SpoVAD) FAE1_CUT1_RppA PF08392.12 ACT02126.1 - 9.5e-05 21.8 0.1 0.0066 15.8 0.0 2.2 2 0 0 2 2 2 1 FAE1/Type III polyketide synthase-like protein Thiolase_C PF02803.18 ACT02126.1 - 0.0043 16.7 1.8 1.3 8.7 0.1 2.7 3 0 0 3 3 3 2 Thiolase, C-terminal domain Chal_sti_synt_C PF02797.15 ACT02126.1 - 0.016 15.2 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 Chalcone and stilbene synthases, C-terminal domain Peptidase_C14 PF00656.22 ACT02126.1 - 0.039 13.9 0.0 0.064 13.2 0.0 1.2 1 0 0 1 1 1 0 Caspase domain ketoacyl-synt PF00109.26 ACT02126.1 - 1.8 8.1 8.9 3.9 7.0 0.6 3.8 3 1 1 4 4 4 0 Beta-ketoacyl synthase, N-terminal domain FA_synthesis PF02504.15 ACT02127.1 - 4.1e-115 384.3 0.9 4.6e-115 384.1 0.9 1.0 1 0 0 1 1 1 1 Fatty acid synthesis protein PrpR_N PF06506.11 ACT02127.1 - 0.023 14.3 0.2 1.8 8.1 0.0 2.9 3 0 0 3 3 3 0 Propionate catabolism activator 4HBT PF03061.22 ACT02128.1 - 0.00034 20.9 0.1 0.00052 20.3 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily HTH_DeoR PF08220.12 ACT02128.1 - 0.00084 19.0 0.5 0.0015 18.3 0.5 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACT02128.1 - 0.0027 17.6 0.3 0.0088 16.0 0.2 1.9 2 0 0 2 2 2 1 HTH domain MaoC_dehydratas PF01575.19 ACT02128.1 - 0.027 14.0 0.1 0.043 13.4 0.1 1.3 1 0 0 1 1 1 0 MaoC like domain Arg_repressor PF01316.21 ACT02128.1 - 0.038 13.7 0.2 0.086 12.6 0.2 1.6 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain HTH_24 PF13412.6 ACT02128.1 - 0.052 13.1 0.1 0.13 11.9 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Ribosomal_L32p PF01783.23 ACT02129.1 - 2.3e-27 95.0 3.6 2.5e-27 94.9 3.6 1.0 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 ACT02129.1 - 0.018 14.5 1.4 0.028 13.8 1.4 1.3 1 0 0 1 1 1 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 ACT02129.1 - 0.51 10.1 4.2 6.6 6.5 0.5 2.1 2 0 0 2 2 2 0 Rubredoxin metal binding domain RecR PF02132.15 ACT02129.1 - 1.8 8.2 0.1 1.8 8.2 0.1 2.3 2 1 1 3 3 3 0 RecR protein YceD PF02620.17 ACT02130.1 - 4.5e-31 107.5 4.9 6.2e-31 107.0 4.9 1.2 1 0 0 1 1 1 1 Large ribosomal RNA subunit accumulation protein YceD HIGH_NTase1 PF05636.11 ACT02131.1 - 5.3e-128 427.6 0.0 6.4e-128 427.4 0.0 1.0 1 0 0 1 1 1 1 HIGH Nucleotidyl Transferase Citrate_ly_lig PF08218.11 ACT02131.1 - 0.0047 16.6 0.1 3.5 7.3 0.0 2.3 2 0 0 2 2 2 2 Citrate lyase ligase C-terminal domain CTP_transf_like PF01467.26 ACT02131.1 - 0.06 13.5 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Cytidylyltransferase-like Lon_C PF05362.13 ACT02132.1 - 1.9e-10 40.6 0.1 2.7e-10 40.1 0.1 1.2 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain Birna_VP4 PF01768.16 ACT02132.1 - 0.004 17.0 0.0 0.0055 16.5 0.0 1.3 1 0 0 1 1 1 1 Birnavirus VP4 protein Gate PF07670.14 ACT02133.1 - 2.3e-05 24.6 2.1 4.8e-05 23.6 0.1 2.6 2 1 0 2 2 2 1 Nucleoside recognition CTP_transf_like PF01467.26 ACT02134.1 - 5.3e-21 75.3 0.0 6.3e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like Citrate_ly_lig PF08218.11 ACT02134.1 - 2.3e-05 24.1 0.0 3.6e-05 23.5 0.0 1.3 1 1 0 1 1 1 1 Citrate lyase ligase C-terminal domain SEN1_N PF12726.7 ACT02134.1 - 0.045 12.0 0.1 0.056 11.7 0.1 1.1 1 0 0 1 1 1 0 SEN1 N terminal Rep_2 PF01719.17 ACT02134.1 - 0.091 12.5 0.1 0.16 11.8 0.0 1.4 1 1 0 1 1 1 0 Plasmid replication protein Cons_hypoth95 PF03602.15 ACT02135.1 - 4.6e-53 179.6 0.0 5.1e-53 179.4 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 ACT02135.1 - 0.00011 21.8 0.0 0.00012 21.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_15 PF09445.10 ACT02135.1 - 0.00016 21.3 0.0 0.00022 20.8 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MethyltransfD12 PF02086.15 ACT02135.1 - 0.002 17.9 0.0 0.73 9.5 0.0 2.2 1 1 1 2 2 2 2 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_25 PF13649.6 ACT02135.1 - 0.003 18.2 0.0 0.024 15.4 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain DUF1453 PF07301.11 ACT02136.1 - 8.5e-05 22.6 5.0 0.00021 21.3 5.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1453) Voltage_CLC PF00654.20 ACT02136.1 - 0.0085 15.4 0.9 0.014 14.7 0.8 1.3 1 1 0 1 1 1 1 Voltage gated chloride channel DctQ PF04290.12 ACT02136.1 - 0.021 14.8 1.3 0.056 13.4 0.1 2.2 3 1 1 4 4 4 0 Tripartite ATP-independent periplasmic transporters, DctQ component Polysacc_synt_C PF14667.6 ACT02136.1 - 0.023 14.7 0.9 0.023 14.7 0.9 2.1 2 1 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain GtrA PF04138.14 ACT02136.1 - 0.03 14.6 1.2 0.07 13.4 1.2 1.8 1 1 0 1 1 1 0 GtrA-like protein DUF2304 PF10066.9 ACT02136.1 - 1.3 9.3 8.3 0.39 11.0 2.4 2.9 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) YkuD PF03734.14 ACT02137.1 - 9.1e-24 84.5 0.1 1.7e-23 83.7 0.1 1.4 1 1 0 1 1 1 1 L,D-transpeptidase catalytic domain Glucosaminidase PF01832.20 ACT02138.1 - 8.2e-11 42.3 0.0 1.3e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Cu_amine_oxidN1 PF07833.11 ACT02138.1 - 2.5e-06 27.9 0.1 0.033 14.7 0.0 2.3 2 0 0 2 2 2 2 Copper amine oxidase N-terminal domain TatD_DNase PF01026.21 ACT02139.1 - 6.2e-47 160.1 0.0 7.1e-47 159.9 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 ACT02139.1 - 0.0059 16.4 1.7 0.028 14.2 1.7 2.3 1 1 0 1 1 1 1 Amidohydrolase ABC_tran PF00005.27 ACT02140.1 - 1.6e-30 106.4 0.0 2.3e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02140.1 - 1.2e-07 31.9 0.2 0.00069 19.5 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT02140.1 - 0.00028 20.4 0.2 0.33 10.3 0.2 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACT02140.1 - 0.00099 19.5 0.0 0.0016 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT02140.1 - 0.0017 18.0 0.1 0.0038 16.9 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACT02140.1 - 0.0069 16.9 0.5 0.012 16.1 0.5 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACT02140.1 - 0.0072 16.6 0.2 0.021 15.1 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ACT02140.1 - 0.018 15.2 0.1 0.09 12.9 0.1 2.1 1 1 0 1 1 1 0 AAA domain RNA12 PF10443.9 ACT02140.1 - 0.022 13.5 0.1 0.036 12.8 0.0 1.3 2 0 0 2 2 2 0 RNA12 protein NACHT PF05729.12 ACT02140.1 - 0.025 14.5 0.6 0.55 10.1 0.1 2.2 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.22 ACT02140.1 - 0.028 13.6 0.3 0.057 12.6 0.1 1.5 2 0 0 2 2 2 0 NB-ARC domain PhoH PF02562.16 ACT02140.1 - 0.029 13.8 0.1 0.12 11.8 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_30 PF13604.6 ACT02140.1 - 0.038 13.7 0.1 0.29 10.8 0.1 2.1 2 1 1 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 ACT02140.1 - 0.047 13.6 0.4 0.11 12.4 0.1 1.7 2 0 0 2 2 1 0 RsgA GTPase AAA_18 PF13238.6 ACT02140.1 - 0.092 13.3 0.4 1.1 9.9 0.2 2.1 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ACT02140.1 - 0.11 11.8 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SAM_1 PF00536.30 ACT02140.1 - 0.13 12.8 0.3 0.55 10.7 0.0 2.1 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ACT02140.1 - 0.14 12.3 0.4 1.5 8.9 0.0 2.2 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) NTPase_1 PF03266.15 ACT02140.1 - 0.17 11.8 0.2 3.3 7.6 0.2 2.1 2 0 0 2 2 2 0 NTPase PduV-EutP PF10662.9 ACT02140.1 - 0.17 11.6 0.0 0.37 10.5 0.0 1.5 2 0 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 ACT02140.1 - 0.17 11.6 0.4 1.2 8.8 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ACT02140.1 - 0.18 11.4 0.4 0.59 9.7 0.0 2.0 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 ACT02140.1 - 0.52 10.5 3.0 1.2 9.4 0.3 2.3 3 0 0 3 3 2 0 AAA domain BPD_transp_1 PF00528.22 ACT02141.1 - 2.3e-25 89.4 14.3 2.3e-25 89.4 14.3 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component QCR10 PF09796.9 ACT02141.1 - 0.98 9.5 3.9 3.2 7.9 0.8 2.6 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Thiamine_BP PF01910.17 ACT02142.1 - 3e-23 81.5 0.0 3.5e-23 81.3 0.0 1.0 1 0 0 1 1 1 1 Thiamine-binding protein NMT1 PF09084.11 ACT02143.1 - 7.2e-73 245.1 0.4 1.1e-72 244.5 0.4 1.3 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 ACT02143.1 - 0.0012 18.6 0.1 0.017 14.8 0.1 2.2 2 0 0 2 2 2 1 NMT1-like family Glycos_transf_1 PF00534.20 ACT02144.1 - 7.2e-13 48.4 0.0 1.4e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT02144.1 - 5.1e-08 33.4 0.0 1.1e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ACT02144.1 - 0.0013 19.1 0.0 0.0028 18.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 GDP_Man_Dehyd PF16363.5 ACT02145.1 - 2e-88 297.0 0.0 4.7e-88 295.8 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ACT02145.1 - 1.2e-59 201.7 0.0 1.4e-59 201.5 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ACT02145.1 - 3.1e-12 46.2 0.0 5.1e-10 39.0 0.0 2.2 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ACT02145.1 - 3.7e-12 46.0 0.0 4.7e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ACT02145.1 - 6.6e-06 26.1 0.0 1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ACT02145.1 - 0.00029 20.1 0.4 0.015 14.5 0.2 2.2 1 1 1 2 2 2 1 Male sterility protein adh_short PF00106.25 ACT02145.1 - 0.00098 18.6 0.0 0.0064 16.0 0.0 2.3 3 0 0 3 3 3 1 short chain dehydrogenase 3Beta_HSD PF01073.19 ACT02145.1 - 0.0011 18.1 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 ACT02145.1 - 0.029 14.3 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 KR domain adh_short_C2 PF13561.6 ACT02145.1 - 0.17 11.4 0.0 0.35 10.4 0.0 1.5 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase NTP_transferase PF00483.23 ACT02146.1 - 5.6e-40 137.5 0.3 5.4e-38 131.0 0.1 2.1 2 0 0 2 2 2 2 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACT02146.1 - 2e-08 34.7 0.0 3.3e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 ACT02146.1 - 0.0026 17.5 0.0 0.0054 16.5 0.0 1.5 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MannoseP_isomer PF01050.18 ACT02146.1 - 0.0037 17.2 0.1 0.0093 15.9 0.1 1.7 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Collagen PF01391.18 ACT02147.1 - 5.1e-05 22.9 20.9 8.2e-05 22.3 20.9 1.4 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) Yae1_N PF09811.9 ACT02148.1 - 0.043 13.5 1.9 0.074 12.8 1.9 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Glycos_transf_2 PF00535.26 ACT02149.1 - 1.3e-27 96.6 0.0 1.8e-27 96.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACT02149.1 - 6.8e-22 78.5 0.0 8.6e-22 78.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ACT02149.1 - 4.7e-09 36.1 0.0 6.1e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_5 PF13712.6 ACT02149.1 - 2.4e-06 27.4 0.0 9.2e-06 25.5 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family Glyco_trans_2_3 PF13632.6 ACT02149.1 - 7.4e-06 26.0 0.0 1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 ACT02149.1 - 1.3e-05 24.7 0.0 2.1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 ACT02149.1 - 0.001 19.5 0.1 0.0043 17.6 0.0 2.2 2 1 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_49 PF13896.6 ACT02149.1 - 0.02 14.2 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl-transferase for dystroglycan Glycos_transf_2 PF00535.26 ACT02150.1 - 8.4e-12 45.2 0.2 1.2e-11 44.7 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 ACT02150.1 - 0.013 15.9 0.0 0.03 14.8 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 ACT02150.1 - 0.12 11.8 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Methyltransf_24 PF13578.6 ACT02151.1 - 6.2e-25 88.3 0.0 8.7e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TylF PF05711.11 ACT02151.1 - 0.0047 16.2 0.0 0.0093 15.3 0.0 1.4 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) CmcI PF04989.12 ACT02151.1 - 0.15 11.7 0.0 0.3 10.8 0.0 1.5 2 0 0 2 2 2 0 Cephalosporin hydroxylase DUF563 PF04577.14 ACT02152.1 - 1.2e-47 162.7 0.0 1.8e-47 162.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Molydop_binding PF01568.21 ACT02152.1 - 0.13 12.3 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain Glycos_transf_1 PF00534.20 ACT02153.1 - 1.5e-16 60.4 0.0 4e-16 59.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT02153.1 - 1.9e-09 38.0 0.0 4.2e-09 36.9 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACT02153.1 - 2.2e-07 31.1 0.6 6.7e-07 29.5 0.6 1.9 1 1 0 1 1 1 1 Glycosyltransferase Family 4 BRE PF06113.12 ACT02153.1 - 0.046 12.6 0.0 0.22 10.4 0.0 1.9 2 0 0 2 2 2 0 Brain and reproductive organ-expressed protein (BRE) Glyco_trans_1_2 PF13524.6 ACT02153.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF4214 PF13946.6 ACT02154.1 - 2e-17 63.0 0.1 7.3e-11 42.0 0.0 2.7 3 0 0 3 3 3 2 Domain of unknown function (DUF4214) Glycos_transf_1 PF00534.20 ACT02154.1 - 8.3e-09 35.2 0.0 2.1e-08 33.9 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 PglD_N PF17836.1 ACT02155.1 - 1.1e-15 58.0 0.2 1.9e-15 57.3 0.2 1.4 1 0 0 1 1 1 1 PglD N-terminal domain Hexapep PF00132.24 ACT02155.1 - 1.6e-13 49.8 17.6 5.1e-06 26.0 0.6 5.2 4 2 2 6 6 6 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACT02155.1 - 1.6e-05 24.5 1.8 1.6e-05 24.5 1.8 4.2 5 1 0 5 5 5 2 Hexapeptide repeat of succinyl-transferase GARS_N PF02844.15 ACT02155.1 - 0.0012 19.5 0.2 0.012 16.4 0.2 2.4 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain DegT_DnrJ_EryC1 PF01041.17 ACT02156.1 - 2e-132 441.9 0.0 2.3e-132 441.7 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 ACT02156.1 - 8.6e-11 41.6 0.0 1.6e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ACT02156.1 - 2.2e-06 26.9 0.0 3.2e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ACT02156.1 - 4.2e-06 26.2 0.0 1.6e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 ACT02156.1 - 0.00039 19.1 0.0 0.0006 18.4 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.20 ACT02156.1 - 0.017 13.9 0.0 0.023 13.4 0.0 1.3 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain GDP_Man_Dehyd PF16363.5 ACT02157.1 - 1.4e-147 491.4 0.0 1.6e-147 491.3 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ACT02157.1 - 8.4e-70 235.0 0.3 1.1e-69 234.6 0.3 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ACT02157.1 - 2.6e-06 26.7 0.0 5.1e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ACT02157.1 - 0.0037 16.4 0.0 0.0052 16.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 ACT02157.1 - 0.02 14.4 0.0 0.043 13.4 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family adh_short PF00106.25 ACT02157.1 - 0.052 13.0 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase DUF3383 PF11863.8 ACT02157.1 - 0.13 11.3 0.0 0.24 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3383) Glu_synthase PF01645.17 ACT02158.1 - 9.9e-79 265.1 0.0 1.2e-78 264.8 0.0 1.0 1 0 0 1 1 1 1 Conserved region in glutamate synthase FMN_dh PF01070.18 ACT02158.1 - 0.0012 18.0 0.6 0.0023 17.0 0.6 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Acetyltransf_3 PF13302.7 ACT02159.1 - 4.2e-24 85.8 0.1 6.4e-24 85.2 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT02159.1 - 2e-08 34.5 0.1 2.7e-08 34.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 ACT02159.1 - 2.2e-06 27.4 0.0 4.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT02159.1 - 3.5e-05 23.7 0.1 0.00011 22.1 0.1 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 ACT02159.1 - 0.00017 21.8 0.1 0.0002 21.5 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Phage_lambda_P PF06992.11 ACT02159.1 - 0.076 12.7 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Replication protein P Pectate_lyase_2 PF06917.12 ACT02159.1 - 0.089 11.4 0.3 0.12 10.9 0.3 1.1 1 0 0 1 1 1 0 Periplasmic pectate lyase KduI PF04962.12 ACT02160.1 - 1.3e-37 129.5 0.0 1.8e-37 129.1 0.0 1.1 1 0 0 1 1 1 1 KduI/IolB family Cupin_2 PF07883.11 ACT02160.1 - 0.16 11.7 0.2 0.96 9.2 0.1 2.3 3 0 0 3 3 3 0 Cupin domain DeoRC PF00455.22 ACT02161.1 - 2e-43 148.1 0.3 2.8e-43 147.6 0.3 1.2 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 ACT02161.1 - 7e-17 60.9 1.1 1.8e-16 59.6 1.1 1.7 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACT02161.1 - 5.4e-10 39.1 0.4 1.7e-09 37.5 0.4 1.9 1 0 0 1 1 1 1 HTH domain GntR PF00392.21 ACT02161.1 - 1e-05 25.1 1.0 2.3e-05 24.0 1.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family TrmB PF01978.19 ACT02161.1 - 6.8e-05 22.7 0.1 0.00022 21.0 0.1 1.9 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.20 ACT02161.1 - 8.4e-05 22.4 0.4 0.00026 20.8 0.1 1.9 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 ACT02161.1 - 8.6e-05 22.0 4.3 0.00043 19.8 0.4 2.9 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_Mga PF08280.11 ACT02161.1 - 9.3e-05 22.4 0.5 0.0004 20.4 0.2 2.2 2 0 0 2 2 2 1 M protein trans-acting positive regulator (MGA) HTH domain Fe_dep_repress PF01325.19 ACT02161.1 - 0.00018 21.6 0.1 0.00089 19.4 0.0 2.1 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain MarR_2 PF12802.7 ACT02161.1 - 0.00039 20.2 0.5 0.0014 18.4 0.5 1.9 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 ACT02161.1 - 0.00069 19.6 0.7 0.013 15.5 0.5 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HemN_C PF06969.16 ACT02161.1 - 0.0034 17.4 0.7 0.0079 16.2 0.7 1.7 1 0 0 1 1 1 1 HemN C-terminal domain MarR PF01047.22 ACT02161.1 - 0.0046 16.9 0.2 0.014 15.3 0.2 1.8 1 0 0 1 1 1 1 MarR family TFIIE_alpha PF02002.17 ACT02161.1 - 0.0052 16.6 0.6 0.0094 15.8 0.6 1.3 1 0 0 1 1 1 1 TFIIE alpha subunit Penicillinase_R PF03965.16 ACT02161.1 - 0.0091 16.3 0.1 0.017 15.5 0.1 1.5 1 0 0 1 1 1 1 Penicillinase repressor HTH_27 PF13463.6 ACT02161.1 - 0.012 16.1 0.6 0.033 14.7 0.2 2.0 2 0 0 2 2 1 0 Winged helix DNA-binding domain Ribosomal_S25 PF03297.15 ACT02161.1 - 0.015 15.5 0.1 0.063 13.5 0.0 2.0 2 0 0 2 2 2 0 S25 ribosomal protein Rrf2 PF02082.20 ACT02161.1 - 0.021 15.2 0.3 0.075 13.4 0.1 2.0 2 0 0 2 2 2 0 Transcriptional regulator HTH_10 PF04967.12 ACT02161.1 - 0.021 14.6 0.1 0.062 13.1 0.1 1.8 1 0 0 1 1 1 0 HTH DNA binding domain HTH_36 PF13730.6 ACT02161.1 - 0.026 14.5 0.1 0.25 11.3 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT02161.1 - 0.063 13.3 0.4 0.19 11.7 0.4 1.8 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain AbiEi_4 PF13338.6 ACT02161.1 - 0.076 13.2 0.4 0.28 11.4 0.2 2.0 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin LexA_DNA_bind PF01726.16 ACT02161.1 - 0.11 12.3 0.1 0.25 11.2 0.1 1.6 1 0 0 1 1 1 0 LexA DNA binding domain EAP30 PF04157.16 ACT02161.1 - 0.12 11.6 0.1 0.26 10.5 0.1 1.5 1 0 0 1 1 1 0 EAP30/Vps36 family adh_short_C2 PF13561.6 ACT02162.1 - 1.6e-57 194.8 1.3 1.9e-57 194.5 1.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT02162.1 - 8.1e-55 185.3 2.8 1.1e-54 184.9 2.8 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT02162.1 - 2.5e-12 47.1 2.0 3.3e-12 46.7 2.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACT02162.1 - 0.0002 20.9 0.5 0.00036 20.1 0.4 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PALP PF00291.25 ACT02162.1 - 0.00025 20.6 0.9 0.00047 19.7 0.9 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme THF_DHG_CYH_C PF02882.19 ACT02162.1 - 0.003 16.9 0.0 0.0056 16.0 0.0 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ELFV_dehydrog PF00208.21 ACT02162.1 - 0.0047 16.7 0.3 0.0067 16.2 0.3 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 ACT02162.1 - 0.014 14.8 0.1 0.025 13.9 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 ACT02162.1 - 0.017 14.5 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ACT02162.1 - 0.023 14.3 1.1 0.039 13.5 1.0 1.4 2 0 0 2 2 2 0 NmrA-like family ACT_7 PF13840.6 ACT02162.1 - 0.039 13.7 0.3 5 7.0 0.0 2.8 2 0 0 2 2 2 0 ACT domain NAD_binding_7 PF13241.6 ACT02162.1 - 0.064 13.7 0.1 0.12 12.8 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding DFP PF04127.15 ACT02162.1 - 0.064 13.1 0.6 0.39 10.5 0.3 2.1 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein F420_oxidored PF03807.17 ACT02162.1 - 0.068 13.8 1.3 0.14 12.8 0.6 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Peptidase_M56 PF05569.11 ACT02163.1 - 7.5e-54 183.0 0.3 4.1e-53 180.5 0.3 1.9 1 1 0 1 1 1 1 BlaR1 peptidase M56 DUF4825 PF16107.5 ACT02163.1 - 1.5e-26 92.4 0.1 3.1e-26 91.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4825) Penicillinase_R PF03965.16 ACT02164.1 - 1.1e-18 67.7 0.2 1.2e-18 67.5 0.2 1.1 1 0 0 1 1 1 1 Penicillinase repressor MarR PF01047.22 ACT02164.1 - 0.00079 19.3 0.1 0.0022 17.9 0.0 1.8 1 1 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT02164.1 - 0.0078 15.8 0.2 0.044 13.3 0.2 2.0 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 ACT02164.1 - 0.0095 15.8 0.0 0.022 14.7 0.0 1.7 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 ACT02164.1 - 0.011 15.5 0.0 0.02 14.7 0.0 1.5 1 1 0 1 1 1 0 IclR helix-turn-helix domain Voltage_CLC PF00654.20 ACT02165.1 - 5.3e-70 236.4 31.8 5.3e-70 236.4 31.8 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel BPD_transp_1 PF00528.22 ACT02166.1 - 4.1e-20 72.3 14.7 4.1e-20 72.3 14.7 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component MscS_TM PF12794.7 ACT02166.1 - 4.8 5.9 11.8 0.28 10.0 0.2 2.6 3 0 0 3 3 3 0 Mechanosensitive ion channel inner membrane domain 1 BPD_transp_1 PF00528.22 ACT02167.1 - 5.4e-08 32.8 30.0 5.4e-08 32.8 30.0 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACT02168.1 - 3.3e-27 96.0 8.8 5.1e-27 95.4 8.8 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02168.1 - 6.3e-19 69.1 14.0 1.2e-18 68.1 14.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Response_reg PF00072.24 ACT02169.1 - 5.3e-27 94.2 0.0 1.3e-26 92.9 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02169.1 - 1.9e-13 50.4 0.0 4.3e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02169.1 - 6.7e-11 42.0 0.0 1.3e-07 31.5 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF3385 PF11865.8 ACT02169.1 - 0.034 14.1 1.4 14 5.5 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3385) His_kinase PF06580.13 ACT02170.1 - 5.8e-25 87.4 0.3 1.4e-24 86.2 0.3 1.7 1 0 0 1 1 1 1 Histidine kinase HATPase_c PF02518.26 ACT02170.1 - 4.4e-08 33.6 0.0 1e-07 32.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACT02170.1 - 1.5e-07 31.4 7.8 3.2e-07 30.4 7.8 1.6 1 1 0 1 1 1 1 Cache domain HAMP PF00672.25 ACT02170.1 - 1.6e-06 28.4 0.3 7.3e-06 26.3 0.2 2.2 2 0 0 2 2 2 1 HAMP domain HATPase_c_5 PF14501.6 ACT02170.1 - 0.04 13.8 0.0 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 GHKL domain HATPase_c_2 PF13581.6 ACT02170.1 - 0.088 12.8 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain FGGY_N PF00370.21 ACT02171.1 - 6.6e-33 114.3 0.0 9e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ACT02171.1 - 2.8e-29 102.3 0.0 4.6e-29 101.6 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain RhaA PF06134.11 ACT02172.1 - 6.2e-231 766.8 0.0 7.2e-231 766.6 0.0 1.0 1 0 0 1 1 1 1 L-rhamnose isomerase (RhaA) adh_short_C2 PF13561.6 ACT02173.1 - 4.2e-46 157.4 2.5 1.5e-45 155.6 2.5 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT02173.1 - 1.5e-45 155.1 2.7 2.8e-45 154.2 2.7 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Aldolase_II PF00596.21 ACT02173.1 - 1.5e-23 83.7 0.0 8.4e-23 81.3 0.0 2.0 2 0 0 2 2 2 1 Class II Aldolase and Adducin N-terminal domain KR PF08659.10 ACT02173.1 - 1.7e-10 41.1 1.1 3.6e-10 40.0 1.1 1.5 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 ACT02173.1 - 3.8e-06 26.5 0.1 6.5e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 ACT02173.1 - 8e-05 22.9 0.2 0.0002 21.6 0.2 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 ACT02173.1 - 0.00014 21.4 0.5 0.00029 20.4 0.5 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ACT02173.1 - 0.00043 19.5 0.1 0.00073 18.8 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 ACT02173.1 - 0.00082 19.9 0.4 0.0023 18.5 0.4 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.19 ACT02173.1 - 0.0034 16.4 0.1 0.0055 15.8 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ACT02173.1 - 0.0054 16.6 0.5 0.0054 16.6 0.5 1.9 2 0 0 2 2 2 1 NAD(P)H-binding 3HCDH_N PF02737.18 ACT02173.1 - 0.008 16.1 0.8 0.017 15.0 0.8 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 ACT02173.1 - 0.016 15.4 0.4 0.081 13.2 0.5 2.1 2 0 0 2 2 2 0 TrkA-N domain Shikimate_DH PF01488.20 ACT02173.1 - 0.037 14.1 0.0 0.24 11.5 0.1 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Ldh_1_N PF00056.23 ACT02173.1 - 0.37 10.9 3.4 0.18 11.9 0.8 1.8 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 ACT02174.1 - 4.5e-19 69.4 0.2 8e-19 68.6 0.2 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT02174.1 - 4.7e-07 29.8 0.0 8.3e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DapB_N PF01113.20 ACT02174.1 - 9.4e-06 25.8 0.1 1.5e-05 25.1 0.1 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus PglD_N PF17836.1 ACT02174.1 - 0.018 15.7 0.0 0.033 14.8 0.0 1.5 1 0 0 1 1 1 0 PglD N-terminal domain AP_endonuc_2 PF01261.24 ACT02175.1 - 3.4e-29 101.8 0.0 4.9e-29 101.3 0.0 1.3 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel AP_endonuc_2_N PF07582.12 ACT02175.1 - 0.0041 16.8 0.0 0.0086 15.8 0.0 1.6 1 0 0 1 1 1 1 AP endonuclease family 2 C terminus IU_nuc_hydro PF01156.19 ACT02175.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Inosine-uridine preferring nucleoside hydrolase HTH_18 PF12833.7 ACT02176.1 - 5.8e-18 64.9 0.0 1.1e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02176.1 - 3.9e-16 58.7 0.0 6.5e-08 32.5 0.0 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02176.1 - 8.7e-13 48.3 1.3 1.5e-12 47.6 0.9 1.7 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02176.1 - 5.9e-09 35.5 0.2 1.2e-08 34.5 0.2 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ACT02176.1 - 0.0014 18.3 0.0 0.0024 17.5 0.0 1.4 1 0 0 1 1 1 1 Cupin MannoseP_isomer PF01050.18 ACT02176.1 - 0.003 17.5 0.0 0.0056 16.6 0.0 1.4 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_6 PF12852.7 ACT02176.1 - 0.0045 16.7 0.0 0.091 12.5 0.0 2.2 2 0 0 2 2 2 1 Cupin Cupin_3 PF05899.12 ACT02176.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF861) ARD PF03079.14 ACT02176.1 - 0.15 12.2 0.5 0.55 10.4 0.1 1.9 2 0 0 2 2 2 0 ARD/ARD' family Cupin_4 PF08007.12 ACT02176.1 - 0.21 11.0 2.8 2.1 7.7 2.8 2.1 1 1 0 1 1 1 0 Cupin superfamily protein IclR PF01614.18 ACT02177.1 - 2.1e-22 79.3 0.0 5.5e-22 78.0 0.0 1.6 2 0 0 2 2 2 1 Bacterial transcriptional regulator HTH_IclR PF09339.10 ACT02177.1 - 2.8e-11 43.0 0.0 4.9e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain MarR_2 PF12802.7 ACT02177.1 - 2.1e-06 27.5 0.0 1.1e-05 25.2 0.0 2.0 2 0 0 2 2 2 1 MarR family Rrf2 PF02082.20 ACT02177.1 - 1.2e-05 25.5 0.1 6.2e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Transcriptional regulator TrmB PF01978.19 ACT02177.1 - 3e-05 23.8 0.0 7.9e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 ACT02177.1 - 0.00028 20.9 0.0 0.00057 19.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain RPA_C PF08784.11 ACT02177.1 - 0.0031 18.2 0.0 0.019 15.6 0.0 2.0 2 0 0 2 2 2 1 Replication protein A C terminal DUF742 PF05331.11 ACT02177.1 - 0.0046 16.8 0.1 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF742) HTH_9 PF08221.11 ACT02177.1 - 0.0056 16.7 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_24 PF13412.6 ACT02177.1 - 0.0058 16.2 0.0 0.016 14.8 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 ACT02177.1 - 0.0088 16.0 0.1 0.71 9.9 0.0 2.5 2 0 0 2 2 2 1 HTH domain HTH_Crp_2 PF13545.6 ACT02177.1 - 0.023 14.7 0.1 0.11 12.5 0.0 2.1 2 1 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_23 PF13384.6 ACT02177.1 - 0.025 14.4 0.0 0.066 13.0 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain TFIIE_alpha PF02002.17 ACT02177.1 - 0.057 13.3 0.4 0.11 12.3 0.0 1.6 2 0 0 2 2 1 0 TFIIE alpha subunit HTH_5 PF01022.20 ACT02177.1 - 0.058 13.3 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Fe_dep_repress PF01325.19 ACT02177.1 - 0.06 13.5 0.1 0.19 12.0 0.1 1.9 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain FeoC PF09012.10 ACT02177.1 - 0.071 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 FeoC like transcriptional regulator MscS_TM PF12794.7 ACT02178.1 - 0.061 12.2 4.7 0.077 11.8 4.7 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF485 PF04341.12 ACT02178.1 - 0.4 10.7 4.3 0.096 12.7 1.2 1.5 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Gaa1 PF04114.14 ACT02178.1 - 0.44 9.5 8.1 0.46 9.4 8.1 1.0 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component UPF0139 PF03669.13 ACT02178.1 - 1 9.3 6.6 0.46 10.4 2.1 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0139) Cu_amine_oxid PF01179.20 ACT02179.1 - 4.4e-169 562.7 0.0 5.5e-169 562.4 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 ACT02179.1 - 2.7e-12 47.0 0.0 5.4e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 ACT02179.1 - 3.3e-12 46.5 0.3 6.4e-12 45.5 0.3 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Ammonium_transp PF00909.21 ACT02180.1 - 5.6e-125 417.2 45.4 6.5e-125 416.9 45.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family P-II PF00543.22 ACT02181.1 - 7.6e-36 122.8 2.4 8.6e-36 122.6 2.4 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II GATase PF00117.28 ACT02182.1 - 2.7e-18 66.4 0.0 3.9e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 ACT02182.1 - 0.00014 21.5 0.0 0.00019 21.1 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 ACT02182.1 - 0.00037 20.3 0.0 0.00072 19.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 ACT02182.1 - 0.055 13.3 0.0 0.082 12.7 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Lipase_GDSL_2 PF13472.6 ACT02183.1 - 2.6e-27 96.4 0.1 3.1e-27 96.1 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ACT02183.1 - 3.5e-09 36.9 0.0 5.8e-09 36.2 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 ACT02183.1 - 0.027 14.6 0.0 0.053 13.6 0.0 1.6 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF4184 PF13803.6 ACT02184.1 - 1.4e-62 211.3 9.1 1.6e-62 211.1 9.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4184) Zn_dep_PLPC PF00882.18 ACT02184.1 - 1.5e-14 54.4 0.3 1.9e-14 54.1 0.3 1.1 1 0 0 1 1 1 1 Zinc dependent phospholipase C YdjM PF04307.14 ACT02184.1 - 0.3 10.4 6.8 6.2 6.1 6.8 2.8 1 1 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase Semialdhyde_dh PF01118.24 ACT02185.1 - 2.6e-11 44.0 0.0 3.7e-10 40.3 0.0 2.4 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain YfmQ PF10787.9 ACT02185.1 - 0.015 15.1 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein from bacillus cereus group DDE_Tnp_1_6 PF13751.6 ACT02186.1 - 6.2e-30 104.0 0.1 1.4e-29 102.9 0.1 1.6 1 0 0 1 1 1 1 Transposase DDE domain DUF772 PF05598.11 ACT02186.1 - 1.5e-19 69.7 0.3 8e-19 67.4 0.3 2.2 2 0 0 2 2 2 1 Transposase domain (DUF772) DDE_Tnp_1 PF01609.21 ACT02186.1 - 3.5e-17 62.8 0.4 2.3e-16 60.1 0.4 2.2 1 1 0 1 1 1 1 Transposase DDE domain EndIII_4Fe-2S PF10576.9 ACT02186.1 - 0.52 10.7 1.6 0.84 10.1 1.6 1.3 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III DUF1690 PF07956.11 ACT02186.1 - 0.72 10.3 6.6 1.7 9.0 6.6 1.6 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) Glyco_hydro_30 PF02055.16 ACT02187.1 - 1.3e-51 175.7 1.1 1.9e-51 175.1 1.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain SLH PF00395.20 ACT02187.1 - 6.2e-39 131.8 4.0 3.9e-16 58.8 0.7 4.0 3 0 0 3 3 3 3 S-layer homology domain CBM_6 PF03422.15 ACT02187.1 - 1.4e-20 73.8 4.0 1.4e-20 73.8 4.0 6.2 7 2 1 8 8 6 1 Carbohydrate binding module (family 6) fn3 PF00041.21 ACT02187.1 - 1.1e-14 54.5 0.2 5.6e-07 29.8 0.1 3.5 3 0 0 3 3 2 2 Fibronectin type III domain Glyco_hydro_59 PF02057.15 ACT02187.1 - 3e-14 53.0 0.1 5.5e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30C PF17189.4 ACT02187.1 - 3.7e-14 52.7 0.1 3.7e-14 52.7 0.1 3.3 3 0 0 3 3 2 1 Glycosyl hydrolase family 30 beta sandwich domain Big_2 PF02368.18 ACT02187.1 - 1.8e-09 37.3 8.7 1.8e-09 37.3 8.7 5.2 5 1 1 6 6 6 1 Bacterial Ig-like domain (group 2) Glyco_hydr_30_2 PF14587.6 ACT02187.1 - 7.6e-08 32.3 0.0 0.0031 17.2 0.0 2.2 2 0 0 2 2 2 2 O-Glycosyl hydrolase family 30 DUF5010_C PF18099.1 ACT02187.1 - 1.2e-06 28.6 3.0 2.4e-06 27.7 0.8 2.8 2 0 0 2 2 2 1 DUF5010 C-terminal domain DUF5013 PF16405.5 ACT02187.1 - 0.00022 21.5 9.5 0.02 15.1 1.2 3.8 3 0 0 3 3 3 2 Domain of unknown function (DUF5013) DUF4998 PF16389.5 ACT02187.1 - 0.00085 19.0 0.0 0.0032 17.1 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function Y_Y_Y PF07495.13 ACT02187.1 - 0.0023 17.9 2.5 0.21 11.6 0.1 4.0 3 0 0 3 3 3 1 Y_Y_Y domain DUF2369 PF10179.9 ACT02187.1 - 0.0043 17.4 0.1 0.023 15.1 0.1 2.2 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2369) SHIRT PF18655.1 ACT02187.1 - 0.25 11.9 2.6 0.78 10.4 0.3 2.8 2 0 0 2 2 2 0 SHIRT domain DUF4249 PF14054.6 ACT02187.1 - 6.1 6.4 8.7 0.64 9.6 1.3 2.6 2 1 0 3 3 3 0 Domain of unknown function (DUF4249) MG2 PF01835.19 ACT02187.1 - 9.7 6.7 10.6 11 6.6 0.1 5.2 6 0 0 6 6 5 0 MG2 domain LOR PF04525.12 ACT02188.1 - 0.014 15.0 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 LURP-one-related Spore_GerAC PF05504.11 ACT02189.1 - 3.9e-26 92.2 0.2 1.9e-25 90.0 0.0 1.9 2 0 0 2 2 2 1 Spore germination B3/ GerAC like, C-terminal Spore_permease PF03845.13 ACT02190.1 - 2.8e-46 157.8 25.1 3.7e-46 157.4 25.1 1.1 1 0 0 1 1 1 1 Spore germination protein GerA PF03323.13 ACT02191.1 - 2.7e-115 385.5 6.2 3.4e-115 385.2 6.2 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Collagen PF01391.18 ACT02192.1 - 1.3e-17 63.3 56.2 8.2e-10 38.3 29.0 2.5 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) BclA_C PF18573.1 ACT02192.1 - 2.9e-07 30.4 2.0 3.7e-07 30.1 2.0 1.2 1 0 0 1 1 1 1 BclA C-terminal domain Cass2 PF14526.6 ACT02193.1 - 1.5e-09 38.2 0.0 1.7e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Integron-associated effector binding protein GyrI-like PF06445.15 ACT02193.1 - 0.0012 19.1 0.0 0.0019 18.5 0.0 1.3 1 1 0 1 1 1 1 GyrI-like small molecule binding domain Methyltransf_25 PF13649.6 ACT02194.1 - 4.7e-10 40.0 0.1 7.5e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT02194.1 - 1.3e-09 38.6 0.0 2.1e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT02194.1 - 9.8e-08 32.7 0.0 1.6e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT02194.1 - 4.9e-06 26.4 0.0 6.8e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT02194.1 - 0.00039 20.3 0.0 0.0008 19.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Melibiase_2 PF16499.5 ACT02195.1 - 7.7e-26 90.9 1.6 9.3e-17 61.1 0.0 2.6 1 1 1 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 ACT02195.1 - 1.5e-14 53.8 0.0 2.8e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Raffinose_syn PF05691.12 ACT02195.1 - 0.099 10.4 0.4 0.4 8.4 0.0 2.1 3 0 0 3 3 3 0 Raffinose synthase or seed imbibition protein Sip1 HTH_18 PF12833.7 ACT02196.1 - 8e-24 83.7 0.0 1.2e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02196.1 - 5.2e-19 67.8 0.0 1.4e-09 37.8 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02196.1 - 3.4e-06 27.0 0.1 8e-06 25.8 0.1 1.7 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_23 PF13384.6 ACT02196.1 - 0.037 13.8 0.0 0.096 12.5 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain TPR_MalT PF17874.1 ACT02197.1 - 1.7e-26 93.4 6.1 1.7e-26 93.4 6.1 2.2 2 0 0 2 2 2 1 MalT-like TPR region GerE PF00196.19 ACT02197.1 - 1.2e-16 60.0 0.0 4.3e-16 58.2 0.0 2.1 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family AAA_16 PF13191.6 ACT02197.1 - 8.5e-09 36.0 1.0 1.5e-07 32.0 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ACT02197.1 - 7.8e-07 29.4 0.0 3.1e-06 27.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain Sigma70_r4_2 PF08281.12 ACT02197.1 - 2.8e-05 23.7 1.2 0.00024 20.7 0.1 2.8 2 0 0 2 2 2 1 Sigma-70, region 4 TPR_10 PF13374.6 ACT02197.1 - 5.4e-05 22.9 1.8 1.3 9.0 0.1 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat HTH_28 PF13518.6 ACT02197.1 - 0.00092 19.3 0.1 19 5.5 0.1 4.1 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_23 PF13384.6 ACT02197.1 - 0.0043 16.8 0.1 2.2 8.2 0.0 4.3 4 1 0 4 4 4 1 Homeodomain-like domain RsgA_GTPase PF03193.16 ACT02197.1 - 0.0072 16.2 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase TPR_14 PF13428.6 ACT02197.1 - 0.018 15.8 9.1 16 6.6 0.3 6.0 4 1 0 4 4 4 0 Tetratricopeptide repeat Sigma70_r4 PF04545.16 ACT02197.1 - 0.02 14.4 0.1 0.13 11.8 0.0 2.5 2 0 0 2 2 2 0 Sigma-70, region 4 TPR_2 PF07719.17 ACT02197.1 - 0.02 15.0 18.8 0.081 13.1 0.0 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat AAA_35 PF14516.6 ACT02197.1 - 0.028 13.2 0.7 0.7 8.7 0.0 3.2 3 1 1 4 4 4 0 AAA-like domain ANAPC5 PF12862.7 ACT02197.1 - 0.04 14.0 1.3 0.2 11.8 0.1 2.6 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 AAA_25 PF13481.6 ACT02197.1 - 0.045 13.3 0.4 0.32 10.5 0.4 2.3 1 1 0 1 1 1 0 AAA domain HTH_10 PF04967.12 ACT02197.1 - 0.055 13.3 0.1 1.5 8.6 0.0 2.7 2 0 0 2 2 2 0 HTH DNA binding domain HTH_40 PF14493.6 ACT02197.1 - 0.066 13.7 0.1 0.96 10.0 0.0 3.1 3 0 0 3 3 2 0 Helix-turn-helix domain DUF433 PF04255.14 ACT02197.1 - 0.079 12.8 0.2 1.8 8.5 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF433) DEAD PF00270.29 ACT02197.1 - 0.12 12.2 0.1 0.57 9.9 0.1 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase TPR_19 PF14559.6 ACT02197.1 - 0.85 10.2 9.5 12 6.5 1.1 4.7 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 ACT02197.1 - 4.9 7.5 11.7 7.2 7.0 0.9 4.8 3 2 0 3 3 3 0 Tetratricopeptide repeat SLH PF00395.20 ACT02198.1 - 2.5e-42 142.6 1.6 1.3e-15 57.1 0.2 4.0 3 0 0 3 3 3 3 S-layer homology domain Big_6 PF17936.1 ACT02198.1 - 2.9e-38 130.0 108.4 6e-10 39.3 1.7 18.6 18 1 0 18 18 18 8 Bacterial Ig domain Kelch_1 PF01344.25 ACT02198.1 - 4.1e-25 87.1 8.9 9.9e-05 21.8 0.0 6.9 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 ACT02198.1 - 7.2e-22 76.9 9.3 0.00065 19.9 0.1 7.0 5 1 1 6 6 6 5 Kelch motif CHB_HEX_C_1 PF13290.6 ACT02198.1 - 1.6e-20 72.9 59.7 0.017 15.1 1.6 15.5 15 0 0 15 15 15 10 Chitobiase/beta-hexosaminidase C-terminal domain Kelch_4 PF13418.6 ACT02198.1 - 3.5e-19 68.5 11.5 0.00012 22.0 0.1 6.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 ACT02198.1 - 7.3e-15 54.3 0.3 0.06 13.3 0.0 6.7 6 0 0 6 6 6 5 Kelch motif Cadherin-like PF12733.7 ACT02198.1 - 1.2e-11 44.9 2.1 1.2e-11 44.9 2.1 13.3 16 1 1 17 17 14 1 Cadherin-like beta sandwich domain Kelch_5 PF13854.6 ACT02198.1 - 2.1e-10 40.4 6.0 0.00016 21.6 0.0 5.0 5 0 0 5 5 4 2 Kelch motif Fn3_assoc PF13287.6 ACT02198.1 - 2.1e-10 40.6 30.0 0.42 10.8 0.1 13.5 13 0 0 13 13 13 3 Fn3 associated Big_3_2 PF12245.8 ACT02198.1 - 5.2e-10 39.7 34.3 1.6 9.0 0.0 15.9 17 1 0 18 18 16 1 Bacterial Ig-like domain Kelch_3 PF13415.6 ACT02198.1 - 1.1e-08 35.1 23.7 0.0051 17.1 0.2 7.8 7 0 0 7 7 7 3 Galactose oxidase, central domain Big_3_3 PF13750.6 ACT02198.1 - 1.8e-06 27.7 42.7 0.1 12.3 0.0 13.0 15 1 1 16 16 15 4 Bacterial Ig-like domain (group 3) HYR PF02494.16 ACT02198.1 - 5.4e-06 26.6 34.7 11 6.4 0.0 15.5 19 0 0 19 19 18 0 HYR domain Big_3_4 PF13754.6 ACT02198.1 - 1.1e-05 25.1 10.7 2.9 7.7 0.1 9.2 10 1 1 11 11 11 1 Domain of unknown function Big_7 PF17957.1 ACT02198.1 - 0.0023 18.6 0.2 0.0023 18.6 0.2 18.1 13 4 6 19 19 18 6 Bacterial Ig domain DUF4625 PF15418.6 ACT02198.1 - 0.0033 17.7 0.9 39 4.5 0.0 6.0 5 0 0 5 5 4 0 Domain of unknown function (DUF4625) DUF5001 PF16392.5 ACT02198.1 - 0.018 15.0 7.1 12 5.9 0.0 6.8 9 0 0 9 9 8 0 Ig-like domain DUF4998 PF16389.5 ACT02198.1 - 0.074 12.6 9.7 12 5.4 0.0 8.4 13 0 0 13 13 13 0 Domain of unknown function DUF1668 PF07893.13 ACT02198.1 - 0.079 12.3 0.1 11 5.3 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1668) HTH_18 PF12833.7 ACT02199.1 - 7.8e-21 74.1 0.0 1.3e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02199.1 - 1.1e-18 66.8 0.0 5.8e-08 32.6 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02199.1 - 2.5e-11 43.6 0.4 5.1e-11 42.6 0.4 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02199.1 - 8.3e-10 38.3 1.6 2e-09 37.0 1.6 1.6 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 ACT02199.1 - 0.0016 18.0 0.1 0.0038 16.9 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF861) AraC_binding_2 PF14525.6 ACT02199.1 - 0.25 11.0 1.4 2.1 8.0 1.4 2.1 1 1 0 1 1 1 0 AraC-binding-like domain Cupin_6 PF12852.7 ACT02199.1 - 0.3 10.8 1.3 1.6 8.4 0.1 2.1 2 0 0 2 2 2 0 Cupin VCBS PF13517.6 ACT02200.1 - 1.1e-30 105.9 16.3 2.6e-08 34.3 0.5 5.5 5 0 0 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ACT02200.1 - 7.9e-21 73.9 17.3 0.0022 18.1 0.6 6.4 6 0 0 6 6 6 6 FG-GAP repeat TcdB_toxin_midN PF12256.8 ACT02200.1 - 0.00081 18.8 5.3 14 5.0 0.1 6.1 3 1 4 7 7 7 2 Insecticide toxin TcdB middle/N-terminal region Dockerin_1 PF00404.18 ACT02200.1 - 0.0053 16.9 6.5 3.1 8.1 0.0 4.6 5 0 0 5 5 5 2 Dockerin type I domain PliI PF16743.5 ACT02200.1 - 0.0069 16.1 0.2 59 3.4 0.0 4.5 4 2 1 5 5 5 0 Periplasmic lysozyme inhibitor of I-type lysozyme Itfg2 PF15907.5 ACT02200.1 - 0.6 9.1 3.5 22 3.9 0.1 3.9 4 1 1 5 5 5 0 Integrin-alpha FG-GAP repeat-containing protein 2 GFO_IDH_MocA PF01408.22 ACT02201.1 - 4e-19 69.6 0.0 6.7e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Ribosomal_S22 PF08136.11 ACT02201.1 - 0.023 15.0 0.0 0.059 13.7 0.0 1.6 1 0 0 1 1 1 0 30S ribosomal protein subunit S22 family NAD_binding_2 PF03446.15 ACT02201.1 - 0.17 12.0 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACT02201.1 - 0.19 12.3 0.1 0.52 10.9 0.0 1.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Beta-lactamase PF00144.24 ACT02202.1 - 7.4e-64 216.1 0.3 9.3e-64 215.7 0.3 1.0 1 0 0 1 1 1 1 Beta-lactamase Glyco_hyd_65N_2 PF14498.6 ACT02203.1 - 2.6e-70 236.9 0.0 4.2e-70 236.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Amidohydro_2 PF04909.14 ACT02204.1 - 9.2e-39 134.0 0.5 1e-38 133.8 0.5 1.0 1 0 0 1 1 1 1 Amidohydrolase DUF4525 PF15027.6 ACT02204.1 - 0.22 11.3 0.0 0.36 10.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) ADH_N PF08240.12 ACT02205.1 - 1.2e-31 108.9 1.1 2.3e-31 107.9 1.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ACT02205.1 - 1.3e-24 86.7 0.1 1.9e-24 86.1 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ACT02205.1 - 8.4e-09 35.2 0.1 1.3e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 ACT02205.1 - 0.00022 20.6 0.3 0.00033 20.0 0.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ACT02205.1 - 0.00027 20.4 0.0 0.00049 19.5 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ACT02205.1 - 0.00031 20.7 0.1 0.0005 20.0 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 ACT02205.1 - 0.0008 20.5 0.1 0.0019 19.3 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 ACT02205.1 - 0.0065 16.1 0.1 0.011 15.3 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 ACT02205.1 - 0.011 16.0 0.1 0.018 15.3 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Oxidored_nitro PF00148.19 ACT02205.1 - 0.022 13.5 0.0 0.87 8.2 0.0 2.2 1 1 1 2 2 2 0 Nitrogenase component 1 type Oxidoreductase Methyltransf_25 PF13649.6 ACT02205.1 - 0.037 14.7 0.0 0.076 13.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Neocarzinostat PF00960.18 ACT02205.1 - 0.042 13.8 0.6 0.82 9.7 0.2 2.4 2 0 0 2 2 2 0 Neocarzinostatin family DUF4350 PF14258.6 ACT02205.1 - 0.05 14.0 0.1 0.45 11.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) NADH_4Fe-4S PF10589.9 ACT02205.1 - 0.097 12.8 1.8 0.23 11.6 1.8 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Pyr_redox_3 PF13738.6 ACT02205.1 - 0.13 11.5 0.1 0.21 10.8 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Aldo_ket_red PF00248.21 ACT02206.1 - 6.9e-49 166.6 0.0 8e-49 166.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_AraC PF00165.23 ACT02207.1 - 4.7e-21 74.4 0.2 4.9e-12 45.6 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT02207.1 - 2.9e-20 72.3 0.0 6.1e-20 71.3 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT02207.1 - 2e-11 44.0 0.1 2.8e-11 43.5 0.1 1.4 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02207.1 - 3.3e-09 36.3 0.1 5.8e-09 35.5 0.1 1.3 1 0 0 1 1 1 1 Cupin domain ARD PF03079.14 ACT02207.1 - 0.06 13.5 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 ARD/ARD' family Auxin_BP PF02041.16 ACT02207.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Auxin binding protein PhyH PF05721.13 ACT02208.1 - 1.7e-33 116.6 0.1 2.1e-33 116.4 0.1 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HTH_18 PF12833.7 ACT02209.1 - 3.1e-24 85.0 0.2 5.7e-24 84.2 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02209.1 - 3.4e-20 71.6 0.3 4.9e-09 36.1 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02209.1 - 3.2e-17 62.7 0.4 3.2e-16 59.5 0.0 2.3 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02209.1 - 4e-11 42.5 0.5 7.7e-11 41.6 0.5 1.4 1 0 0 1 1 1 1 Cupin domain Ectoine_synth PF06339.12 ACT02209.1 - 0.0001 22.5 0.1 0.00018 21.7 0.1 1.4 1 0 0 1 1 1 1 Ectoine synthase AraC_binding_2 PF14525.6 ACT02209.1 - 0.00037 20.2 0.0 0.00065 19.4 0.0 1.3 1 0 0 1 1 1 1 AraC-binding-like domain HTH_Crp_2 PF13545.6 ACT02209.1 - 0.044 13.8 0.1 0.12 12.4 0.1 1.7 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain Cupin_3 PF05899.12 ACT02209.1 - 0.054 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) HTH_6 PF01418.17 ACT02209.1 - 0.1 12.6 0.1 0.26 11.3 0.1 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain, rpiR family TraC PF07820.12 ACT02209.1 - 0.12 12.7 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 TraC-like protein UPF0175 PF03683.13 ACT02209.1 - 0.13 12.0 0.1 0.52 10.1 0.1 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0175) ARD PF03079.14 ACT02209.1 - 0.13 12.5 0.2 0.24 11.6 0.2 1.4 1 0 0 1 1 1 0 ARD/ARD' family IU_nuc_hydro PF01156.19 ACT02210.1 - 3.9e-21 75.9 0.0 5.7e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF1593 PF07632.11 ACT02210.1 - 0.00051 19.6 0.1 0.021 14.3 0.1 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1593) AraC_binding PF02311.19 ACT02211.1 - 6.8e-19 68.1 0.0 1.1e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_18 PF12833.7 ACT02211.1 - 2.4e-17 63.0 0.0 3.8e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02211.1 - 3.6e-10 39.7 0.0 2e-05 24.6 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT02211.1 - 7.3e-06 25.6 0.0 1.5e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 ACT02211.1 - 0.00023 20.8 0.1 0.00045 19.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) AraC_binding_2 PF14525.6 ACT02211.1 - 0.0054 16.4 0.0 0.0098 15.6 0.0 1.4 1 0 0 1 1 1 1 AraC-binding-like domain Glyco_hydro_2_C PF02836.17 ACT02212.1 - 1.5e-117 392.0 0.1 2.2e-117 391.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 ACT02212.1 - 6.8e-74 248.5 0.0 1.3e-73 247.6 0.0 1.4 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 ACT02212.1 - 1.2e-42 145.7 2.4 9.2e-42 142.8 2.8 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 ACT02212.1 - 5.3e-26 90.9 0.2 1.7e-25 89.3 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 ACT02212.1 - 2.9e-18 66.5 0.3 7.1e-18 65.3 0.1 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 DUF3426 PF11906.8 ACT02212.1 - 0.0032 17.6 0.1 0.024 14.8 0.1 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF3426) CARDB PF07705.11 ACT02212.1 - 0.016 15.4 0.5 2.8 8.3 0.0 2.7 2 0 0 2 2 2 0 CARDB BetaGal_dom4_5 PF13364.6 ACT02212.1 - 0.024 15.2 0.0 0.072 13.7 0.0 1.8 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain HAD_2 PF13419.6 ACT02213.1 - 1.2e-13 51.5 0.0 1.8e-13 51.0 0.0 1.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT02213.1 - 3.2e-12 47.2 0.0 4.2e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT02213.1 - 0.001 19.1 0.0 0.0019 18.3 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like DHDPS PF00701.22 ACT02214.1 - 1.2e-57 194.8 0.0 1.4e-57 194.7 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Glyco_hydro_127 PF07944.12 ACT02215.1 - 3.1e-148 494.5 0.0 3.7e-148 494.3 0.0 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_76 PF03663.14 ACT02215.1 - 0.0048 16.5 0.1 0.59 9.6 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 ACT02215.1 - 0.12 11.4 0.2 2.4 7.1 0.0 2.3 1 1 0 2 2 2 0 Glycosyl Hydrolase Family 88 Hydrolase_3 PF08282.12 ACT02216.1 - 2.2e-48 165.2 0.0 2.6e-48 165.0 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ACT02216.1 - 3.8e-16 59.4 0.0 4.2e-08 33.0 0.0 2.4 2 1 1 3 3 3 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 ACT02216.1 - 6.9e-07 29.8 0.6 0.005 17.2 0.0 3.3 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT02216.1 - 1.1e-06 29.2 2.3 0.14 12.5 0.0 3.3 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 ACT02216.1 - 2.3e-05 23.6 0.0 0.0012 18.1 0.0 2.2 2 0 0 2 2 2 1 Trehalose-phosphatase HAD_2 PF13419.6 ACT02216.1 - 0.024 14.7 0.0 1.2 9.2 0.0 2.5 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ACT02216.1 - 0.03 14.4 0.0 0.94 9.6 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase PfaD_N PF18328.1 ACT02216.1 - 0.12 12.4 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 Fatty acid synthase subunit PfaD N-terminal domain GFO_IDH_MocA PF01408.22 ACT02217.1 - 2.2e-18 67.2 0.1 7.6e-18 65.5 0.1 1.9 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT02217.1 - 0.071 13.1 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain ADH_N PF08240.12 ACT02218.1 - 1.5e-16 60.2 0.3 2.7e-16 59.4 0.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ACT02218.1 - 9.3e-13 48.3 0.0 1.4e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ACT02218.1 - 6.2e-12 45.4 0.1 9.2e-12 44.9 0.1 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ACT02218.1 - 1.8e-05 25.8 0.0 3.7e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.18 ACT02218.1 - 0.00059 20.1 0.1 0.001 19.3 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain Peripla_BP_1 PF00532.21 ACT02219.1 - 6.2e-31 107.8 0.0 8e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 ACT02219.1 - 4.5e-27 95.4 0.0 5e-26 92.0 0.0 2.0 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_4 PF13407.6 ACT02219.1 - 7.7e-20 71.6 0.0 3.2e-19 69.5 0.0 1.8 2 0 0 2 2 2 1 Periplasmic binding protein domain LacI PF00356.21 ACT02219.1 - 4.9e-10 39.0 0.6 1.5e-09 37.5 0.1 2.2 2 0 0 2 2 2 1 Bacterial regulatory proteins, lacI family HTH_10 PF04967.12 ACT02219.1 - 0.004 16.9 0.2 0.36 10.7 0.0 2.4 2 0 0 2 2 2 1 HTH DNA binding domain HTH_24 PF13412.6 ACT02219.1 - 0.0051 16.3 0.1 0.052 13.1 0.0 2.5 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_3 PF01381.22 ACT02219.1 - 0.011 15.7 0.1 0.027 14.5 0.1 1.7 1 1 0 1 1 1 0 Helix-turn-helix TetR_N PF00440.23 ACT02219.1 - 0.023 14.5 0.4 0.12 12.2 0.0 2.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, tetR family SMC_hinge PF06470.13 ACT02219.1 - 0.032 14.5 0.0 0.18 12.1 0.0 2.3 1 1 0 1 1 1 0 SMC proteins Flexible Hinge Domain HTH_26 PF13443.6 ACT02219.1 - 0.07 13.6 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain HTH_15 PF12324.8 ACT02219.1 - 0.094 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase HTH_35 PF13693.6 ACT02219.1 - 0.3 11.2 1.2 0.9 9.6 0.1 2.4 3 1 1 4 4 4 0 Winged helix-turn-helix DNA-binding BPD_transp_1 PF00528.22 ACT02220.1 - 2.2e-18 66.7 14.2 2.2e-18 66.7 14.2 1.6 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF563 PF04577.14 ACT02220.1 - 0.056 13.6 0.1 0.1 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF563) 60KD_IMP PF02096.20 ACT02220.1 - 1.2 9.0 8.9 0.075 12.9 2.6 1.9 2 0 0 2 2 2 0 60Kd inner membrane protein BPD_transp_1 PF00528.22 ACT02221.1 - 1.3e-12 47.8 21.6 1.3e-12 47.8 21.6 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACT02222.1 - 1.2e-28 100.7 13.7 1.7e-28 100.3 13.7 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02222.1 - 9.2e-24 85.0 11.8 9.2e-24 85.0 11.8 1.6 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein DUF1699 PF08004.11 ACT02222.1 - 0.065 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1699) BROMI PF14961.6 ACT02222.1 - 0.16 9.3 0.0 0.22 8.9 0.0 1.0 1 0 0 1 1 1 0 Broad-minded protein Aminotran_1_2 PF00155.21 ACT02223.1 - 3.1e-46 158.2 0.0 3.7e-46 157.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ACT02223.1 - 0.0002 20.1 0.0 0.00027 19.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 ACT02223.1 - 0.011 15.1 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_3 PF00202.21 ACT02223.1 - 0.016 13.9 0.0 0.021 13.5 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III Aminotran_MocR PF12897.7 ACT02223.1 - 0.03 13.1 0.0 0.047 12.5 0.0 1.3 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase Aminotran_5 PF00266.19 ACT02223.1 - 0.061 12.3 0.0 0.093 11.7 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V BenE PF03594.13 ACT02224.1 - 5.8e-61 206.4 35.2 6.5e-61 206.2 35.2 1.0 1 0 0 1 1 1 1 Benzoate membrane transport protein MFS_MOT1 PF16983.5 ACT02224.1 - 1.8e-05 25.1 2.8 1.8e-05 25.1 2.8 4.1 3 2 2 5 5 5 2 Molybdate transporter of MFS superfamily TetR_C_33 PF13305.6 ACT02224.1 - 0.036 14.8 0.6 7.5 7.3 0.1 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain FGGY_N PF00370.21 ACT02225.1 - 6.1e-67 225.7 0.0 7.9e-67 225.4 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ACT02225.1 - 1.3e-34 119.7 0.0 2.8e-34 118.6 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 ACT02225.1 - 2.6e-05 23.9 0.1 0.0052 16.3 0.0 2.8 3 1 0 3 3 3 2 BadF/BadG/BcrA/BcrD ATPase family GntP_permease PF02447.16 ACT02226.1 - 6.7e-166 552.4 45.6 8.3e-166 552.1 45.6 1.0 1 0 0 1 1 1 1 GntP family permease CitMHS PF03600.16 ACT02226.1 - 6.4e-23 81.4 43.2 6.4e-23 81.4 43.2 1.9 1 1 1 2 2 2 1 Citrate transporter Na_H_antiport_2 PF13726.6 ACT02226.1 - 0.00097 19.2 22.2 0.022 14.9 10.3 3.6 3 0 0 3 3 3 2 Na+-H+ antiporter family Response_reg PF00072.24 ACT02227.1 - 6.9e-27 93.8 0.0 1.6e-26 92.7 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02227.1 - 1.1e-17 64.1 0.1 1.1e-16 60.9 0.0 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02227.1 - 1.8e-09 37.5 0.0 9.1e-06 25.6 0.0 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family His_kinase PF06580.13 ACT02228.1 - 6.7e-19 68.0 1.1 1.4e-18 67.0 1.1 1.5 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT02228.1 - 2.2e-06 27.7 0.1 2.2e-06 27.7 0.1 2.0 2 0 0 2 2 2 1 Cache domain HAMP PF00672.25 ACT02228.1 - 3.8e-05 24.0 0.0 0.00011 22.5 0.0 1.9 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT02228.1 - 0.0016 18.9 0.0 0.0035 17.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CobA_CobO_BtuR PF02572.15 ACT02228.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP SBP_bac_1 PF01547.25 ACT02229.1 - 3.5e-44 152.0 4.9 6.8e-44 151.1 4.9 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT02229.1 - 2.6e-36 125.9 0.2 4.3e-36 125.2 0.2 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT02229.1 - 4.9e-05 23.2 0.1 1.1 8.9 0.1 3.3 2 1 0 2 2 2 2 Bacterial extracellular solute-binding protein HTH_5 PF01022.20 ACT02230.1 - 2.2e-09 37.0 0.1 3.9e-09 36.2 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACT02230.1 - 1.3e-06 28.3 0.1 2.2e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 ACT02230.1 - 0.00022 21.1 0.1 0.00041 20.2 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT02230.1 - 0.0019 17.7 0.0 0.0073 15.8 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ACT02230.1 - 0.002 18.0 0.0 0.0048 16.7 0.0 1.6 2 0 0 2 2 2 1 MarR family Mga PF05043.13 ACT02230.1 - 0.0061 17.1 0.2 0.012 16.2 0.2 1.4 1 0 0 1 1 1 1 Mga helix-turn-helix domain HTH_28 PF13518.6 ACT02230.1 - 0.016 15.3 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_34 PF13601.6 ACT02230.1 - 0.035 14.3 0.0 0.062 13.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_CodY PF08222.11 ACT02230.1 - 0.045 13.3 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 CodY helix-turn-helix domain HTH_11 PF08279.12 ACT02230.1 - 0.084 12.8 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 HTH domain HxlR PF01638.17 ACT02230.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Alpha-L-AF_C PF06964.12 ACT02231.1 - 1.5e-44 152.1 0.0 2.2e-44 151.5 0.0 1.2 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Spore_permease PF03845.13 ACT02232.1 - 2.3e-55 187.7 37.8 2.7e-55 187.4 37.8 1.1 1 0 0 1 1 1 1 Spore germination protein DUF3989 PF13150.6 ACT02232.1 - 0.63 9.8 2.4 0.76 9.6 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) Spore_GerAC PF05504.11 ACT02233.1 - 1.3e-28 100.3 0.6 1.7e-28 99.9 0.6 1.2 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal GerA PF03323.13 ACT02234.1 - 2.6e-187 623.0 4.7 3.1e-187 622.7 4.7 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein DDE_Tnp_IS1595 PF12762.7 ACT02234.1 - 0.19 11.7 0.4 0.61 10.1 0.1 1.8 1 1 1 2 2 2 0 ISXO2-like transposase domain EHN PF06441.12 ACT02235.1 - 2.5e-38 130.8 0.5 6.3e-38 129.5 0.2 1.8 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 ACT02235.1 - 4.1e-08 33.2 0.1 9.4e-08 32.0 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACT02235.1 - 0.009 16.6 2.4 0.009 16.6 2.4 1.7 2 1 0 2 2 2 1 Alpha/beta hydrolase family Bap31_Bap29_C PF18035.1 ACT02235.1 - 0.21 11.6 0.2 0.37 10.8 0.2 1.4 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Peripla_BP_2 PF01497.18 ACT02236.1 - 6.4e-22 78.3 0.3 1.2e-21 77.3 0.0 1.5 2 0 0 2 2 2 1 Periplasmic binding protein HTH_18 PF12833.7 ACT02236.1 - 6.5e-18 64.8 0.0 1.2e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02236.1 - 5.8e-12 45.4 0.3 4.8e-07 29.7 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02236.1 - 0.00024 21.0 0.0 0.00048 20.1 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain HBM PF16591.5 ACT02236.1 - 0.029 13.8 0.6 0.049 13.1 0.6 1.3 1 0 0 1 1 1 0 Helical bimodular sensor domain AraC_N PF06719.13 ACT02236.1 - 0.14 11.8 0.0 0.56 9.8 0.0 2.0 2 0 0 2 2 2 0 AraC-type transcriptional regulator N-terminus AraC_binding_2 PF14525.6 ACT02236.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 AraC-binding-like domain DUF29 PF01724.16 ACT02236.1 - 0.42 10.8 5.4 1 9.5 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF29 Peripla_BP_2 PF01497.18 ACT02237.1 - 3.3e-24 85.8 0.1 4.4e-24 85.3 0.1 1.2 1 0 0 1 1 1 1 Periplasmic binding protein Glyco_hydro_43 PF04616.14 ACT02238.1 - 8.7e-09 35.1 9.3 1.3e-07 31.2 9.3 3.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 ACT02238.1 - 1.9e-05 24.4 8.3 0.00021 21.0 3.7 3.3 1 1 2 3 3 3 3 Glycosyl hydrolases family 32 N-terminal domain BNR_2 PF13088.6 ACT02238.1 - 0.009 15.3 0.4 0.012 14.9 0.4 1.3 1 0 0 1 1 1 1 BNR repeat-like domain BPD_transp_1 PF00528.22 ACT02239.1 - 2.5e-11 43.6 19.4 2.5e-11 43.6 19.4 2.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02240.1 - 3e-15 56.4 12.2 3e-15 56.4 12.2 1.8 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component YbjM PF11045.8 ACT02240.1 - 0.084 13.0 0.1 0.084 13.0 0.1 2.8 3 1 0 3 3 3 0 Putative inner membrane protein of Enterobacteriaceae SBP_bac_1 PF01547.25 ACT02241.1 - 5.8e-07 29.8 6.4 3.6e-05 23.9 6.4 2.3 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT02241.1 - 0.0052 17.4 2.1 0.02 15.5 1.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) N-glycanase_C PF09113.10 ACT02241.1 - 0.079 12.7 0.6 0.23 11.2 0.6 1.8 1 0 0 1 1 1 0 Peptide-N-glycosidase F, C terminal Response_reg PF00072.24 ACT02242.1 - 5.9e-29 100.5 0.0 1.2e-28 99.5 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02242.1 - 1.1e-19 70.4 0.1 5.1e-19 68.3 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02242.1 - 8.8e-13 48.0 0.2 1.2e-07 31.7 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family His_kinase PF06580.13 ACT02243.1 - 5.5e-22 77.9 1.0 1.5e-21 76.5 0.2 2.2 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT02243.1 - 3.9e-14 53.0 3.1 3.9e-14 53.0 3.1 1.6 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACT02243.1 - 5.7e-07 30.0 0.1 1.3e-06 28.9 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT02243.1 - 0.005 17.2 0.0 0.017 15.5 0.0 2.0 2 0 0 2 2 2 1 HAMP domain DUF948 PF06103.11 ACT02243.1 - 0.016 15.4 0.1 13 6.1 0.0 3.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) 2CSK_N PF08521.10 ACT02243.1 - 0.024 14.7 0.0 0.056 13.5 0.0 1.6 1 0 0 1 1 1 0 Two-component sensor kinase N-terminal Ly49 PF08391.10 ACT02243.1 - 0.52 10.7 5.1 2.5 8.5 0.2 2.7 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region Alpha-L-AF_C PF06964.12 ACT02244.1 - 1.1e-44 152.5 0.1 2e-44 151.7 0.1 1.4 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain CBM_4_9 PF02018.17 ACT02244.1 - 1e-07 32.3 0.1 1.4e-06 28.6 0.0 2.6 2 1 1 3 3 3 1 Carbohydrate binding domain CBM60 PF16841.5 ACT02244.1 - 0.16 12.4 0.0 16 6.0 0.0 2.6 2 0 0 2 2 2 0 Ca-dependent carbohydrate-binding module xylan-binding HTH_18 PF12833.7 ACT02245.1 - 1.1e-19 70.5 0.0 1.9e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02245.1 - 2.7e-14 52.8 0.1 1.3e-05 25.1 0.1 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02245.1 - 1.3e-05 25.2 0.9 3.4e-05 23.8 0.9 1.8 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02245.1 - 0.022 14.4 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 Cupin domain PhyH PF05721.13 ACT02246.1 - 1.9e-22 80.6 0.0 2.6e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Acetyltransf_3 PF13302.7 ACT02247.1 - 2.4e-11 44.5 0.0 3.5e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain F5_F8_type_C PF00754.25 ACT02248.1 - 5.6e-28 97.6 21.8 4.1e-18 65.7 3.8 3.8 3 1 0 3 3 3 2 F5/8 type C domain CARDB PF07705.11 ACT02248.1 - 3.2e-26 91.6 46.0 3.8e-21 75.3 8.0 6.4 6 0 0 6 6 6 3 CARDB CBM_35 PF16990.5 ACT02248.1 - 1.1e-09 38.5 5.4 1.1e-09 38.5 5.4 4.8 5 0 0 5 5 5 1 Carbohydrate binding module (family 35) CBM_6 PF03422.15 ACT02248.1 - 8.8e-09 35.7 7.7 8.8e-09 35.7 7.7 7.9 6 2 2 9 9 9 2 Carbohydrate binding module (family 6) Beta_helix PF13229.6 ACT02248.1 - 1e-06 28.7 30.5 1e-06 28.7 30.5 6.0 5 2 2 7 7 6 2 Right handed beta helix region DUF5000 PF16391.5 ACT02248.1 - 0.00017 21.8 0.1 9.3 6.4 0.0 4.2 3 1 1 4 4 4 2 Domain of unknown function Trypan_PARP PF05887.11 ACT02248.1 - 0.001 19.0 20.2 0.0025 17.8 20.2 1.6 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Laminin_N PF00055.17 ACT02248.1 - 0.0036 16.9 0.1 0.32 10.5 0.1 2.5 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) Fn3-like PF14310.6 ACT02248.1 - 0.02 15.0 0.0 0.19 11.9 0.0 2.7 2 0 0 2 2 2 0 Fibronectin type III-like domain DUF5010_C PF18099.1 ACT02248.1 - 0.02 15.0 1.2 0.25 11.5 0.3 3.3 2 0 0 2 2 2 0 DUF5010 C-terminal domain Filamin PF00630.19 ACT02248.1 - 2.5 9.0 6.7 8.3 7.3 0.0 4.3 2 2 1 4 4 4 0 Filamin/ABP280 repeat Amidohydro_3 PF07969.11 ACT02249.1 - 6.6e-11 42.3 1.6 2.6e-07 30.5 1.6 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 ACT02249.1 - 1.4e-09 37.7 0.0 1.9e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family ABC_tran PF00005.27 ACT02250.1 - 6.9e-32 110.8 0.0 9.7e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02250.1 - 9.3e-10 38.8 4.0 0.0004 20.3 0.2 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT02250.1 - 0.00017 21.2 0.2 0.00037 20.2 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 ACT02250.1 - 0.00022 20.7 0.2 0.0031 17.0 0.2 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ACT02250.1 - 0.00028 20.7 0.2 0.0026 17.5 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 ACT02250.1 - 0.00037 21.1 0.1 0.00062 20.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACT02250.1 - 0.002 18.4 0.2 0.057 13.7 0.1 2.2 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ACT02250.1 - 0.002 17.5 0.1 0.0034 16.8 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF3584 PF12128.8 ACT02250.1 - 0.0054 14.3 0.2 0.0077 13.8 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_27 PF13514.6 ACT02250.1 - 0.012 15.2 0.0 0.047 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ACT02250.1 - 0.014 15.4 0.2 0.024 14.6 0.2 1.4 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 ACT02250.1 - 0.022 15.1 0.1 0.032 14.6 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ACT02250.1 - 0.024 14.5 0.2 0.044 13.7 0.2 1.4 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 ACT02250.1 - 0.026 13.7 0.3 0.052 12.7 0.3 1.4 1 0 0 1 1 1 0 NB-ARC domain SRP54 PF00448.22 ACT02250.1 - 0.027 14.1 0.1 0.041 13.5 0.1 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_30 PF13604.6 ACT02250.1 - 0.03 14.1 0.3 0.044 13.5 0.3 1.6 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 ACT02250.1 - 0.051 13.2 0.1 0.09 12.4 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_ATPase PF09818.9 ACT02250.1 - 0.051 12.4 0.1 0.18 10.6 0.5 1.6 2 0 0 2 2 2 0 Predicted ATPase of the ABC class MMR_HSR1 PF01926.23 ACT02250.1 - 0.082 13.0 0.2 0.15 12.1 0.2 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase TsaE PF02367.17 ACT02250.1 - 0.088 12.8 0.2 0.15 12.1 0.2 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MobB PF03205.14 ACT02250.1 - 0.1 12.5 0.2 0.19 11.6 0.2 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.6 ACT02250.1 - 0.14 11.9 0.2 0.21 11.3 0.2 1.2 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ACT02250.1 - 0.15 11.3 0.1 0.24 10.7 0.1 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.6 ACT02250.1 - 0.16 11.5 0.2 0.59 9.7 0.2 2.0 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ACT02250.1 - 0.18 12.0 0.1 0.26 11.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_13 PF13166.6 ACT02250.1 - 0.19 10.3 0.0 0.29 9.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 ACT02250.1 - 0.21 11.3 0.1 0.34 10.6 0.1 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family DLIC PF05783.11 ACT02250.1 - 0.24 10.2 0.3 0.35 9.7 0.3 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_28 PF13521.6 ACT02250.1 - 0.25 11.6 0.5 0.66 10.2 0.5 1.7 2 0 0 2 2 1 0 AAA domain BPD_transp_2 PF02653.16 ACT02251.1 - 5.5e-40 137.2 34.3 7.9e-40 136.7 34.3 1.2 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component ABC_tran PF00005.27 ACT02251.1 - 5.3e-30 104.7 0.0 7.7e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02251.1 - 3.8e-07 30.2 0.8 0.00059 19.7 0.2 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system BCA_ABC_TP_C PF12399.8 ACT02251.1 - 9.1e-07 28.7 0.0 1.9e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_29 PF13555.6 ACT02251.1 - 0.00039 20.1 0.1 0.00094 18.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ACT02251.1 - 0.00072 19.3 0.4 0.0033 17.2 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ACT02251.1 - 0.0016 19.0 0.1 0.0027 18.2 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACT02251.1 - 0.0063 16.8 1.1 0.13 12.5 1.1 2.2 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT02251.1 - 0.0099 15.8 0.3 0.02 14.8 0.3 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_15 PF13175.6 ACT02251.1 - 0.014 15.2 0.0 0.02 14.6 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ACT02251.1 - 0.028 14.8 0.1 1.3 9.4 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_27 PF13514.6 ACT02251.1 - 0.076 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ACT02251.1 - 0.077 13.4 0.6 0.24 11.8 0.6 1.8 1 1 0 1 1 1 0 AAA ATPase domain DuoxA PF10204.9 ACT02251.1 - 0.098 11.6 8.4 0.24 10.4 8.4 1.6 1 0 0 1 1 1 0 Dual oxidase maturation factor SMC_N PF02463.19 ACT02251.1 - 0.18 11.2 0.2 0.37 10.2 0.0 1.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Mg_chelatase PF01078.21 ACT02251.1 - 0.18 11.2 0.1 0.43 9.9 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI BPD_transp_2 PF02653.16 ACT02252.1 - 3.5e-37 128.0 32.3 4e-37 127.8 32.3 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component Peripla_BP_6 PF13458.6 ACT02253.1 - 4.7e-55 187.6 8.8 5.6e-55 187.4 8.8 1.1 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.28 ACT02253.1 - 5.3e-20 71.8 0.0 6.2e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_5 PF13433.6 ACT02253.1 - 1.2e-14 54.1 4.0 8.9e-14 51.2 4.0 1.9 1 1 0 1 1 1 1 Periplasmic binding protein domain LytR_C PF13399.6 ACT02253.1 - 0.25 12.3 2.9 1.8 9.6 2.8 2.4 1 1 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator Amidohydro_3 PF07969.11 ACT02254.1 - 7.3e-28 98.3 0.5 4.3e-22 79.2 0.1 2.0 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 ACT02254.1 - 5.4e-13 49.0 0.0 9.7e-13 48.1 0.0 1.4 1 1 0 1 1 1 1 Amidohydrolase family PucR PF07905.11 ACT02255.1 - 4.1e-28 98.0 0.1 8.3e-28 97.0 0.1 1.5 1 0 0 1 1 1 1 Purine catabolism regulatory protein-like family HTH_30 PF13556.6 ACT02255.1 - 4.8e-18 64.7 0.2 1.5e-17 63.1 0.2 2.0 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain GGDEF_2 PF17853.1 ACT02255.1 - 2.6e-16 59.9 0.0 5.2e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 GGDEF-like domain GxGYxYP_C PF14323.6 ACT02256.1 - 4.7e-66 223.1 2.2 4.7e-66 223.1 2.2 2.4 3 0 0 3 3 3 1 GxGYxYP putative glycoside hydrolase C-terminal domain GxGYxYP_N PF16216.5 ACT02256.1 - 1.9e-63 214.5 0.7 5.1e-62 209.9 0.0 3.2 3 0 0 3 3 3 1 GxGYxY sequence motif in domain of unknown function N-terminal DUF1093 PF06486.11 ACT02256.1 - 0.18 12.5 0.7 0.49 11.1 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1093) GATase_3 PF07685.14 ACT02257.1 - 7.8e-59 198.6 0.0 1.1e-58 198.1 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain CbiA PF01656.23 ACT02257.1 - 2e-22 79.6 0.0 3.1e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 ACT02257.1 - 2.5e-22 79.7 0.0 1.2e-21 77.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain SNO PF01174.19 ACT02257.1 - 0.033 14.0 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 SNO glutamine amidotransferase family Peptidase_S51 PF03575.17 ACT02257.1 - 0.058 13.0 0.0 0.094 12.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S51 DJ-1_PfpI PF01965.24 ACT02257.1 - 0.13 12.1 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 DJ-1/PfpI family ABC_tran PF00005.27 ACT02258.1 - 1.1e-29 103.7 0.0 2e-29 102.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT02258.1 - 7.9e-07 28.7 0.3 0.0002 20.9 0.3 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT02258.1 - 2.2e-06 27.7 0.0 0.0073 16.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 ACT02258.1 - 0.0015 19.1 0.0 0.0044 17.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT02258.1 - 0.003 18.0 0.1 0.0081 16.6 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 ACT02258.1 - 0.0031 17.6 0.0 0.0064 16.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ACT02258.1 - 0.004 16.9 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT02258.1 - 0.0056 16.6 0.0 0.018 14.9 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 ACT02258.1 - 0.014 15.9 0.0 0.04 14.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ACT02258.1 - 0.022 15.0 0.0 0.2 11.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 ACT02258.1 - 0.042 13.6 0.0 0.13 12.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ACT02258.1 - 0.051 13.5 0.0 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 NTPase AAA_15 PF13175.6 ACT02258.1 - 0.053 13.2 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 ACT02258.1 - 0.071 12.8 0.0 0.2 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ACT02258.1 - 0.088 13.1 0.0 0.26 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ACT02259.1 - 5.1e-29 101.5 0.0 8.5e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02259.1 - 1e-07 32.1 0.1 0.0081 16.0 0.1 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT02259.1 - 2.9e-06 26.9 0.5 0.00065 19.2 0.5 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 ACT02259.1 - 0.00012 21.4 0.1 0.00076 18.8 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin AAA_29 PF13555.6 ACT02259.1 - 0.001 18.8 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF815 PF05673.13 ACT02259.1 - 0.008 15.4 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) G-alpha PF00503.20 ACT02259.1 - 0.015 14.5 0.0 0.027 13.6 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit AAA_16 PF13191.6 ACT02259.1 - 0.016 15.6 0.0 0.057 13.8 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain dNK PF01712.19 ACT02259.1 - 0.034 14.0 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_15 PF13175.6 ACT02259.1 - 0.047 13.4 0.0 0.088 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 ACT02259.1 - 0.049 13.7 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 ACT02259.1 - 0.052 13.7 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ACT02259.1 - 0.069 13.4 0.0 0.22 11.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ACT02259.1 - 0.074 13.6 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACT02259.1 - 0.082 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_24 PF13479.6 ACT02259.1 - 0.095 12.4 0.0 0.58 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Glyco_hydro_20 PF00728.22 ACT02260.1 - 5e-17 62.3 0.0 8.5e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 ACT02260.1 - 4.6e-08 33.9 0.0 1.1e-07 32.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 PilZ_2 PF16823.5 ACT02260.1 - 0.0023 18.1 0.2 0.079 13.1 0.3 2.9 3 1 0 3 3 3 1 Atypical PilZ domain, cyclic di-GMP receptor LRR_10 PF18805.1 ACT02260.1 - 0.11 12.2 0.6 0.27 10.9 0.6 1.6 1 0 0 1 1 1 0 Leucine-rich repeat Glyco_hydro_3_C PF01915.22 ACT02261.1 - 6.3e-56 189.6 0.0 1.4e-55 188.4 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ACT02261.1 - 2.6e-49 168.4 0.0 5.3e-49 167.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ACT02261.1 - 1.2e-26 92.6 0.0 2.3e-26 91.7 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.21 ACT02262.1 - 2.3e-72 244.1 0.0 3.1e-72 243.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ACT02262.1 - 1.3e-54 185.2 0.0 2.3e-54 184.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ACT02262.1 - 4.3e-22 78.0 0.0 9.5e-22 76.9 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain BPD_transp_1 PF00528.22 ACT02263.1 - 1.4e-10 41.2 17.4 1.4e-10 41.2 17.4 2.8 1 1 2 3 3 3 1 Binding-protein-dependent transport system inner membrane component DUF2157 PF09925.9 ACT02263.1 - 2.7 7.7 11.3 17 5.2 9.5 2.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) BPD_transp_1 PF00528.22 ACT02264.1 - 3e-14 53.2 16.3 3e-14 53.2 16.3 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component MNHE PF01899.16 ACT02264.1 - 0.96 9.2 8.4 0.26 11.0 4.5 2.0 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit Caveolin PF01146.17 ACT02264.1 - 6.8 6.6 8.0 6.8 6.7 2.0 2.5 2 0 0 2 2 2 0 Caveolin DUF3502 PF12010.8 ACT02265.1 - 7.8e-48 162.4 0.7 1.8e-47 161.2 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACT02265.1 - 2e-09 37.8 7.0 2e-09 37.8 7.0 1.8 2 1 0 2 2 2 1 Bacterial extracellular solute-binding protein LPAM_2 PF13627.6 ACT02265.1 - 5.7 6.9 5.3 12 5.8 5.3 1.6 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Response_reg PF00072.24 ACT02266.1 - 1.6e-25 89.4 0.0 8.9e-25 87.0 0.0 2.1 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02266.1 - 9.5e-22 77.1 0.3 1.1e-20 73.6 0.1 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02266.1 - 2.8e-19 68.7 0.2 2e-09 37.3 0.0 2.7 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT02266.1 - 0.023 14.9 0.1 0.14 12.4 0.0 2.2 2 0 0 2 2 2 0 GGDEF-like domain His_kinase PF06580.13 ACT02267.1 - 1.7e-21 76.3 4.8 3.8e-21 75.2 4.8 1.7 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACT02267.1 - 3.3e-11 43.4 0.3 1.1e-10 41.7 0.0 2.1 2 0 0 2 2 2 1 HAMP domain HATPase_c PF02518.26 ACT02267.1 - 6.4e-07 29.9 0.0 1.5e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACT02267.1 - 0.0028 17.5 1.2 0.032 14.0 1.3 2.2 1 1 0 1 1 1 1 Cache domain PdxA PF04166.12 ACT02268.1 - 2.4e-107 358.6 0.1 2.7e-107 358.4 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal phosphate biosynthetic protein PdxA SBD_N PF07005.11 ACT02269.1 - 8.1e-64 215.5 0.0 1.3e-63 214.8 0.0 1.3 1 0 0 1 1 1 1 Sugar-binding N-terminal domain NBD_C PF17042.5 ACT02269.1 - 3.5e-37 128.5 3.6 3.5e-37 128.5 3.6 1.8 2 0 0 2 2 2 1 Nucleotide-binding C-terminal domain KdgT PF03812.13 ACT02270.1 - 3e-119 397.9 33.7 3.3e-119 397.7 33.7 1.0 1 0 0 1 1 1 1 2-keto-3-deoxygluconate permease PrpR_N PF06506.11 ACT02271.1 - 7.4e-54 181.8 0.5 1.7e-53 180.6 0.5 1.6 1 0 0 1 1 1 1 Propionate catabolism activator Sigma54_activ_2 PF14532.6 ACT02271.1 - 1.3e-14 54.5 0.0 2.9e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 ACT02271.1 - 2.6e-12 46.3 0.2 1e-11 44.4 0.2 2.1 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family Sigma54_activat PF00158.26 ACT02271.1 - 2.9e-12 46.6 0.0 1.5e-11 44.3 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain HTH_24 PF13412.6 ACT02271.1 - 0.0003 20.3 0.0 0.00082 18.9 0.0 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding PAS_8 PF13188.7 ACT02271.1 - 0.00051 20.0 0.0 0.0021 18.0 0.0 2.1 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 ACT02271.1 - 0.0049 16.9 0.0 0.014 15.4 0.0 1.8 1 0 0 1 1 1 1 PAS fold AAA_16 PF13191.6 ACT02271.1 - 0.016 15.6 0.1 0.066 13.6 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain HetR_C PF18460.1 ACT02271.1 - 0.019 14.9 0.0 0.065 13.2 0.0 1.9 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain HTH_7 PF02796.15 ACT02271.1 - 0.041 14.0 0.0 0.2 11.8 0.0 2.2 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase AIRC PF00731.20 ACT02271.1 - 0.044 13.4 0.1 0.22 11.1 0.0 2.0 2 0 0 2 2 2 0 AIR carboxylase HTH_23 PF13384.6 ACT02271.1 - 0.051 13.4 0.0 0.15 11.9 0.0 1.9 1 0 0 1 1 1 0 Homeodomain-like domain AAA_22 PF13401.6 ACT02271.1 - 0.055 13.7 0.1 0.38 11.0 0.0 2.5 2 1 0 2 2 2 0 AAA domain PAS_9 PF13426.7 ACT02271.1 - 0.092 13.0 0.0 0.32 11.3 0.0 1.9 1 0 0 1 1 1 0 PAS domain NACHT PF05729.12 ACT02271.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ACT02271.1 - 0.12 12.7 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase HTH_50 PF18024.1 ACT02271.1 - 0.17 11.5 0.3 1.4 8.6 0.0 2.7 2 1 0 2 2 2 0 Helix-turn-helix domain AraC_N PF06719.13 ACT02272.1 - 1e-36 125.8 0.0 1.4e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 AraC-type transcriptional regulator N-terminus HTH_18 PF12833.7 ACT02272.1 - 8.7e-18 64.4 0.0 1.6e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02272.1 - 3.1e-13 49.5 0.3 1.1e-07 31.8 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family TetR_N PF00440.23 ACT02272.1 - 0.0058 16.4 0.2 0.019 14.8 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family HTH_11 PF08279.12 ACT02272.1 - 0.084 12.8 0.0 0.61 10.1 0.0 2.3 2 0 0 2 2 2 0 HTH domain AraC_binding PF02311.19 ACT02272.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 AraC-like ligand binding domain MFS_1 PF07690.16 ACT02273.1 - 2.9e-44 151.5 49.8 2.9e-44 151.5 49.8 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 ACT02273.1 - 0.0019 17.1 23.6 0.019 13.8 5.6 2.7 2 1 1 3 3 3 2 MFS_1 like family SASP PF00269.20 ACT02274.1 - 9.8e-26 89.6 0.0 1.1e-25 89.4 0.0 1.0 1 0 0 1 1 1 1 Small, acid-soluble spore proteins, alpha/beta type Glyco_hydro_127 PF07944.12 ACT02275.1 - 1e-167 558.8 0.0 1.2e-167 558.6 0.0 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 PriCT_2 PF08707.11 ACT02275.1 - 0.072 13.5 0.1 0.35 11.3 0.0 2.1 2 0 0 2 2 2 0 Primase C terminal 2 (PriCT-2) Glyco_hydro_76 PF03663.14 ACT02275.1 - 0.16 11.4 1.2 0.63 9.5 0.0 2.4 3 0 0 3 3 3 0 Glycosyl hydrolase family 76 HTH_18 PF12833.7 ACT02276.1 - 1.1e-20 73.7 0.5 4.7e-19 68.4 0.1 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02276.1 - 2.4e-16 59.4 0.1 3.5e-07 30.1 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02276.1 - 9.4e-07 28.8 0.7 2.1e-06 27.7 0.7 1.7 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02276.1 - 0.028 14.1 0.1 0.063 13.0 0.1 1.7 1 0 0 1 1 1 0 Cupin domain DUF805 PF05656.14 ACT02278.1 - 0.074 13.5 2.7 0.08 13.4 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF805) DUF1980 PF09323.10 ACT02278.1 - 0.98 9.3 3.3 1 9.2 3.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) SPT_ssu-like PF11779.8 ACT02278.1 - 1.3 8.7 6.3 4.7 6.9 0.2 2.1 2 0 0 2 2 2 0 Small subunit of serine palmitoyltransferase-like DUF4309 PF14172.6 ACT02279.1 - 1.3e-33 115.9 0.7 1.6e-33 115.6 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4309) CBM_6 PF03422.15 ACT02279.1 - 0.049 13.9 0.1 0.11 12.8 0.1 1.7 1 0 0 1 1 1 0 Carbohydrate binding module (family 6) Asp-Al_Ex PF06826.12 ACT02279.1 - 0.09 12.6 0.0 0.18 11.6 0.0 1.5 1 1 0 1 1 1 0 Predicted Permease Membrane Region Pkinase PF00069.25 ACT02280.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain PIRT PF15099.6 ACT02281.1 - 0.033 13.8 1.0 0.034 13.7 1.0 1.2 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Herpes_LMP2 PF07415.11 ACT02281.1 - 0.11 11.2 3.8 0.2 10.4 3.8 1.4 1 1 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein DUF3040 PF11239.8 ACT02281.1 - 4.4 7.7 8.6 3.8 7.8 3.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) AI-2E_transport PF01594.16 ACT02282.1 - 7.1e-40 137.1 44.9 9.3e-40 136.7 44.9 1.1 1 0 0 1 1 1 1 AI-2E family transporter Acetyltransf_9 PF13527.7 ACT02283.1 - 1.5e-14 54.1 0.0 5.4e-14 52.4 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT02283.1 - 1.2e-07 31.9 0.0 4.4e-07 30.1 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT02283.1 - 3.6e-05 24.1 0.0 0.00015 22.1 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT02283.1 - 0.00017 21.5 0.0 0.00048 20.0 0.0 1.7 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ACT02283.1 - 0.00062 19.7 0.1 0.016 15.1 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACT02283.1 - 0.017 15.2 0.0 0.037 14.1 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase NodA PF02474.15 ACT02283.1 - 0.12 12.1 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein A (NodA) Glyco_hyd_65N_2 PF14498.6 ACT02284.1 - 2.6e-09 37.3 0.0 4.4e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain BPD_transp_1 PF00528.22 ACT02285.1 - 3.5e-18 66.0 13.1 3.5e-18 66.0 13.1 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02286.1 - 1e-15 58.0 13.0 1e-15 58.0 13.0 1.7 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component MNHE PF01899.16 ACT02286.1 - 0.00084 19.1 2.1 0.0024 17.6 2.1 1.7 1 0 0 1 1 1 1 Na+/H+ ion antiporter subunit SBP_bac_1 PF01547.25 ACT02287.1 - 1.9e-12 47.7 18.7 2.9e-12 47.2 18.7 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT02287.1 - 0.00046 20.8 0.6 0.0011 19.6 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) HTH_18 PF12833.7 ACT02288.1 - 5.9e-17 61.7 0.0 1.2e-16 60.8 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain dCache_1 PF02743.18 ACT02288.1 - 2.6e-10 40.5 3.6 4.8e-10 39.7 3.6 1.4 1 0 0 1 1 1 1 Cache domain GGDEF_2 PF17853.1 ACT02288.1 - 6.9e-08 32.8 0.0 2.9e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 GGDEF-like domain HTH_AraC PF00165.23 ACT02288.1 - 2e-06 27.8 0.2 0.00017 21.6 0.0 3.2 3 0 0 3 3 3 1 Bacterial regulatory helix-turn-helix proteins, AraC family DUF412 PF04217.13 ACT02288.1 - 0.022 14.6 0.2 0.06 13.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF412 BIV_Env PF05858.12 ACT02288.1 - 0.15 10.2 0.4 9.1 4.3 0.1 2.2 2 0 0 2 2 2 0 Bovine immunodeficiency virus surface protein (SU) GATase_4 PF13230.6 ACT02289.1 - 0.016 14.2 0.0 0.016 14.2 0.0 1.0 1 0 0 1 1 1 0 Glutamine amidotransferases class-II MerR_1 PF13411.6 ACT02291.1 - 1.4e-11 44.3 0.9 2.4e-11 43.6 0.5 1.7 1 1 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT02291.1 - 0.00011 21.8 0.1 0.00025 20.7 0.1 1.6 1 0 0 1 1 1 1 MerR family regulatory protein GFO_IDH_MocA PF01408.22 ACT02292.1 - 3.8e-12 47.1 0.0 6.6e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Cu_amine_oxidN1 PF07833.11 ACT02293.1 - 1.1e-16 61.0 0.1 9.5e-14 51.7 0.1 3.2 3 2 1 4 4 4 2 Copper amine oxidase N-terminal domain DUF903 PF06004.12 ACT02293.1 - 0.0049 16.7 0.1 3 7.8 0.0 3.7 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF903) Big_2 PF02368.18 ACT02293.1 - 4 7.4 11.8 0.29 11.1 0.9 3.6 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 2) DUF4038 PF13204.6 ACT02295.1 - 3e-110 368.7 1.4 3.6e-110 368.4 1.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) Collagen_bind_2 PF12904.7 ACT02295.1 - 8.5e-33 112.2 0.0 1.5e-32 111.4 0.0 1.4 1 0 0 1 1 1 1 Putative collagen-binding domain of a collagenase Amidohydro_2 PF04909.14 ACT02296.1 - 1.1e-26 94.3 1.3 1.5e-26 93.9 1.3 1.2 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 ACT02296.1 - 9.2e-05 21.9 0.5 0.00027 20.4 0.5 1.8 1 1 0 1 1 1 1 Amidohydrolase family TatD_DNase PF01026.21 ACT02296.1 - 0.00019 20.9 0.0 0.0013 18.2 0.0 1.9 1 1 0 1 1 1 1 TatD related DNase GFO_IDH_MocA PF01408.22 ACT02297.1 - 6.1e-28 98.1 0.0 1.1e-27 97.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ACT02297.1 - 0.00039 21.0 0.0 0.00059 20.5 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain CoA_binding_2 PF13380.6 ACT02297.1 - 0.0038 17.7 0.0 0.0086 16.6 0.0 1.5 2 0 0 2 2 2 1 CoA binding domain GFO_IDH_MocA_C PF02894.17 ACT02297.1 - 0.0046 17.0 0.0 0.012 15.6 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain AP_endonuc_2 PF01261.24 ACT02298.1 - 5.9e-15 55.3 0.0 1.5e-14 53.9 0.0 1.7 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel FCD PF07729.12 ACT02299.1 - 8.9e-22 77.8 1.4 8.9e-22 77.8 1.4 1.4 2 0 0 2 2 2 1 FCD domain GntR PF00392.21 ACT02299.1 - 1.7e-15 56.4 0.1 3.5e-15 55.4 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_29 PF13551.6 ACT02299.1 - 0.0075 16.3 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix PFO_beta_C PF12367.8 ACT02299.1 - 0.16 12.1 0.4 10 6.3 0.2 2.9 1 1 1 2 2 2 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal HTH_5 PF01022.20 ACT02300.1 - 2.9e-10 39.9 0.0 4.7e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACT02300.1 - 3.1e-09 36.7 0.1 6e-09 35.8 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 ACT02300.1 - 7.6e-08 32.2 0.2 1.7e-07 31.0 0.2 1.5 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT02300.1 - 2e-06 27.6 0.0 4.8e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.20 ACT02300.1 - 0.00013 22.3 0.0 0.00024 21.4 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator HTH_29 PF13551.6 ACT02300.1 - 0.00043 20.3 0.3 0.00065 19.7 0.3 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_24 PF13412.6 ACT02300.1 - 0.00044 19.8 0.1 0.00082 18.9 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_CodY PF08222.11 ACT02300.1 - 0.0012 18.3 0.0 0.0021 17.6 0.0 1.3 1 0 0 1 1 1 1 CodY helix-turn-helix domain Fe_dep_repress PF01325.19 ACT02300.1 - 0.0057 16.8 0.3 0.019 15.2 0.0 1.9 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain HTH_34 PF13601.6 ACT02300.1 - 0.0064 16.7 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_Crp_2 PF13545.6 ACT02300.1 - 0.03 14.3 0.2 0.058 13.4 0.2 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_23 PF13384.6 ACT02300.1 - 0.059 13.2 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Mga PF08280.11 ACT02300.1 - 0.075 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_40 PF14493.6 ACT02300.1 - 0.087 13.3 0.1 0.24 11.9 0.1 1.7 1 1 1 2 2 2 0 Helix-turn-helix domain TrmB PF01978.19 ACT02300.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_28 PF13518.6 ACT02300.1 - 0.12 12.5 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_27 PF13463.6 ACT02300.1 - 0.16 12.5 0.1 0.26 11.8 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain B-block_TFIIIC PF04182.12 ACT02300.1 - 0.17 12.1 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC HTH_11 PF08279.12 ACT02300.1 - 0.18 11.8 0.1 0.31 11.0 0.1 1.3 1 0 0 1 1 1 0 HTH domain Glyco_hydro_43 PF04616.14 ACT02301.1 - 4.6e-83 278.9 0.3 6.4e-83 278.4 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 ACT02301.1 - 1e-26 94.0 0.0 1.5e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Glyco_hydro_32N PF00251.20 ACT02301.1 - 0.0078 15.8 0.1 0.14 11.7 0.0 1.8 1 1 1 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain Acetyltransf_1 PF00583.25 ACT02302.1 - 0.00069 19.8 0.0 0.00088 19.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT02302.1 - 0.016 15.6 2.0 0.063 13.7 2.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT02302.1 - 0.029 14.3 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain MFS_1 PF07690.16 ACT02303.1 - 4.1e-43 147.7 42.8 4.1e-43 147.7 42.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT02303.1 - 1.5e-07 30.7 36.1 3.5e-07 29.5 12.7 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_4 PF06779.14 ACT02303.1 - 0.0019 17.6 28.3 0.0029 16.9 28.3 1.3 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 ACT02303.1 - 0.0081 14.6 21.7 0.013 13.9 20.5 1.7 1 1 1 2 2 2 2 Transmembrane secretion effector Bac_rhamnosid6H PF17389.2 ACT02304.1 - 6.2e-23 81.6 0.8 1.6e-22 80.3 0.8 1.7 1 1 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain GDE_C PF06202.14 ACT02304.1 - 0.00021 20.3 0.0 0.00034 19.7 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Trehalase PF01204.18 ACT02304.1 - 0.0034 16.3 0.0 0.005 15.7 0.0 1.1 1 0 0 1 1 1 1 Trehalase Bac_rhamnosid_C PF17390.2 ACT02304.1 - 0.007 16.1 0.0 0.021 14.6 0.0 1.9 1 1 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain APOC4 PF15119.6 ACT02304.1 - 0.037 14.3 1.0 0.16 12.2 0.1 2.3 2 0 0 2 2 2 0 Apolipoprotein C4 HTH_AraC PF00165.23 ACT02305.1 - 1.7e-27 94.9 0.1 1.2e-12 47.6 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT02305.1 - 3.7e-26 91.2 0.0 8.1e-26 90.1 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT02305.1 - 7e-10 38.9 0.2 1.7e-09 37.7 0.2 1.8 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02305.1 - 3.2e-07 30.0 0.1 3.2e-07 30.0 0.1 1.8 2 0 0 2 2 2 1 Cupin domain ARD PF03079.14 ACT02305.1 - 0.0041 17.3 0.4 0.0041 17.3 0.4 1.9 2 1 0 2 2 2 1 ARD/ARD' family TetR_N PF00440.23 ACT02305.1 - 0.0046 16.7 0.0 0.43 10.4 0.0 2.8 3 0 0 3 3 3 1 Bacterial regulatory proteins, tetR family Ectoine_synth PF06339.12 ACT02305.1 - 0.022 14.9 0.1 0.088 13.0 0.1 1.8 2 0 0 2 2 2 0 Ectoine synthase Cupin_1 PF00190.22 ACT02305.1 - 0.089 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Cupin SLH PF00395.20 ACT02306.1 - 2.1e-44 149.3 8.3 2.2e-16 59.6 0.1 3.5 3 0 0 3 3 3 3 S-layer homology domain Cohesin PF00963.18 ACT02306.1 - 8e-07 29.4 3.6 8e-07 29.4 3.6 1.7 2 0 0 2 2 2 1 Cohesin domain Glyco_hydro_3_C PF01915.22 ACT02307.1 - 5.7e-37 127.7 1.6 1.4e-36 126.4 1.6 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ACT02307.1 - 1.1e-20 73.4 0.0 4.4e-20 71.6 0.0 2.1 1 0 0 1 1 1 1 Fibronectin type III-like domain Cohesin PF00963.18 ACT02307.1 - 1.1e-12 48.3 0.5 1.1e-12 48.3 0.5 3.2 3 0 0 3 3 2 1 Cohesin domain CBM_6 PF03422.15 ACT02307.1 - 1e-09 38.8 0.3 1e-09 38.8 0.3 4.2 4 0 0 4 4 4 1 Carbohydrate binding module (family 6) Glyco_hydro_3 PF00933.21 ACT02307.1 - 1e-08 35.0 0.4 1e-07 31.7 0.0 2.6 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain He_PIG PF05345.12 ACT02307.1 - 2.1e-08 34.2 1.0 1.2e-07 31.7 1.0 2.5 1 0 0 1 1 1 1 Putative Ig domain Dockerin_1 PF00404.18 ACT02307.1 - 7e-05 22.9 3.3 0.0003 20.9 3.3 2.2 1 0 0 1 1 1 1 Dockerin type I domain FIVAR PF07554.13 ACT02307.1 - 0.00069 20.3 3.5 0.0031 18.3 3.5 2.3 1 0 0 1 1 1 1 FIVAR domain EF-hand_1 PF00036.32 ACT02307.1 - 0.0087 15.5 1.1 0.022 14.3 0.0 2.3 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 ACT02307.1 - 0.019 14.8 0.4 0.2 11.7 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain DUF4972 PF16342.5 ACT02307.1 - 0.025 14.2 0.0 0.061 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4972) EF-hand_7 PF13499.6 ACT02307.1 - 0.029 14.8 0.2 0.39 11.2 0.2 2.3 1 1 1 2 2 2 0 EF-hand domain pair Cadherin_5 PF17892.1 ACT02307.1 - 0.1 12.6 0.0 0.1 12.6 0.0 4.1 4 0 0 4 4 4 0 Cadherin-like domain EF-hand_5 PF13202.6 ACT02307.1 - 0.35 10.5 4.6 0.15 11.6 0.1 2.6 3 0 0 3 3 2 0 EF hand BPD_transp_1 PF00528.22 ACT02308.1 - 5.7e-17 62.1 15.9 5.7e-17 62.1 15.9 1.9 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Sigma_reg_N PF13800.6 ACT02308.1 - 0.56 10.5 4.0 0.96 9.8 0.0 3.0 3 0 0 3 3 3 0 Sigma factor regulator N-terminal BPD_transp_1 PF00528.22 ACT02309.1 - 2.1e-14 53.7 19.2 2.1e-14 53.7 19.2 2.0 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACT02310.1 - 1.1e-34 120.6 5.8 1.5e-34 120.1 5.8 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02310.1 - 6e-29 102.0 8.5 9.2e-29 101.4 8.5 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT02310.1 - 0.00061 19.3 0.0 0.14 11.6 0.0 2.4 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein TarH PF02203.15 ACT02311.1 - 0.016 15.2 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 Tar ligand binding domain homologue dCache_1 PF02743.18 ACT02311.1 - 0.021 14.6 1.9 0.027 14.3 1.9 1.1 1 0 0 1 1 1 0 Cache domain DUF3461 PF11944.8 ACT02311.1 - 0.06 13.5 0.2 0.11 12.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) Abhydrolase_1 PF00561.20 ACT02311.1 - 0.093 12.4 0.1 0.14 11.8 0.1 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold His_kinase PF06580.13 ACT02312.1 - 3.7e-20 72.0 0.9 1e-19 70.6 0.9 1.7 1 0 0 1 1 1 1 Histidine kinase HATPase_c PF02518.26 ACT02312.1 - 0.00014 22.3 0.0 0.00028 21.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT02312.1 - 0.025 14.4 0.0 0.05 13.4 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT02312.1 - 0.047 14.1 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 HAMP domain TraB PF01963.17 ACT02312.1 - 0.061 13.2 1.0 0.2 11.5 0.8 1.8 2 0 0 2 2 2 0 TraB family SieB PF14163.6 ACT02312.1 - 0.067 12.7 0.5 0.16 11.5 0.5 1.6 1 0 0 1 1 1 0 Super-infection exclusion protein B Response_reg PF00072.24 ACT02313.1 - 2.6e-21 75.9 0.2 6.7e-21 74.6 0.2 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT02313.1 - 4.6e-20 71.2 2.2 5.7e-10 39.0 0.0 3.7 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT02313.1 - 1.8e-16 60.2 0.0 6.8e-16 58.3 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HHH_4 PF14490.6 ACT02313.1 - 0.037 14.0 0.7 0.41 10.7 0.2 2.4 1 1 1 2 2 2 0 Helix-hairpin-helix containing domain FAS_N PF17828.1 ACT02313.1 - 0.16 12.0 1.6 0.37 10.8 1.6 1.6 1 0 0 1 1 1 0 N-terminal domain in fatty acid synthase subunit beta Glyco_hydro_106 PF17132.4 ACT02314.1 - 6.7e-16 57.8 0.8 3e-10 39.1 0.0 2.8 4 0 0 4 4 4 2 alpha-L-rhamnosidase Glyco_hydro_2_N PF02837.18 ACT02314.1 - 0.072 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain Stomoxyn PF11585.8 ACT02314.1 - 0.14 12.2 0.0 0.42 10.6 0.0 1.8 1 0 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn BPD_transp_1 PF00528.22 ACT02316.1 - 9.7e-14 51.5 26.1 1.5e-11 44.3 26.1 2.4 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component GPI2 PF06432.11 ACT02316.1 - 0.26 10.7 7.3 0.15 11.5 3.7 2.0 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase TrbC PF04956.13 ACT02316.1 - 3 8.1 11.1 0.63 10.3 6.3 2.4 2 1 0 2 2 2 0 TrbC/VIRB2 family BPD_transp_1 PF00528.22 ACT02317.1 - 3e-10 40.2 15.6 3e-10 40.2 15.6 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Cyt-b5 PF00173.28 ACT02317.1 - 0.089 13.0 0.1 2.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Cytochrome b5-like Heme/Steroid binding domain Response_reg PF00072.24 ACT02318.1 - 5.8e-23 81.2 0.1 1.8e-22 79.6 0.1 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02318.1 - 6.7e-22 77.6 0.3 2.2e-21 75.9 0.2 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02318.1 - 8.2e-14 51.3 0.4 7.7e-06 25.9 0.0 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT02318.1 - 4.5e-08 33.3 0.1 1.7e-07 31.5 0.1 2.0 1 0 0 1 1 1 1 GGDEF-like domain GGDEF PF00990.21 ACT02318.1 - 0.11 12.3 0.1 0.5 10.1 0.0 2.1 2 0 0 2 2 2 0 Diguanylate cyclase, GGDEF domain DUF2120 PF09893.9 ACT02318.1 - 0.27 11.4 6.8 0.88 9.7 0.0 4.2 5 1 1 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2120) YTV PF07639.11 ACT02318.1 - 0.36 10.9 1.9 0.53 10.4 0.2 2.0 2 0 0 2 2 2 0 YTV TMF_TATA_bd PF12325.8 ACT02318.1 - 1.5 9.1 7.5 4.8 7.4 6.1 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding His_kinase PF06580.13 ACT02319.1 - 1.4e-22 79.8 1.5 1.4e-22 79.8 1.5 2.4 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT02319.1 - 1.2e-10 41.6 1.1 1.2e-10 41.6 1.1 1.8 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACT02319.1 - 2.1e-06 28.2 0.0 4.1e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT02319.1 - 2.5e-06 27.8 0.0 4.9e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 HAMP domain DUF3130 PF11328.8 ACT02319.1 - 0.086 13.1 0.1 0.3 11.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3130 HATPase_c_3 PF13589.6 ACT02319.1 - 0.14 12.0 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase adh_short_C2 PF13561.6 ACT02320.1 - 1.6e-63 214.4 1.8 1.8e-63 214.3 1.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT02320.1 - 1.5e-51 174.7 1.3 2e-51 174.3 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT02320.1 - 1.6e-11 44.5 0.8 3.2e-11 43.5 0.3 1.6 1 1 1 2 2 2 1 KR domain THF_DHG_CYH_C PF02882.19 ACT02320.1 - 0.062 12.6 0.1 0.74 9.1 0.0 2.3 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TetR_N PF00440.23 ACT02321.1 - 2.7e-12 46.3 0.0 5.9e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Aldo_ket_red PF00248.21 ACT02322.1 - 3.5e-64 216.8 0.0 4e-64 216.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MerR_1 PF13411.6 ACT02323.1 - 1.2e-20 73.4 0.4 2.4e-20 72.4 0.1 1.6 2 0 0 2 2 2 1 MerR HTH family regulatory protein MerR PF00376.23 ACT02323.1 - 2.9e-13 49.3 1.0 4.6e-13 48.7 1.0 1.3 1 0 0 1 1 1 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT02323.1 - 3.4e-13 49.9 2.0 3.4e-13 49.9 2.0 1.5 2 0 0 2 2 2 1 MerR, DNA binding Phytochelatin PF05023.14 ACT02323.1 - 0.00036 19.8 0.0 0.00042 19.6 0.0 1.2 1 0 0 1 1 1 1 Phytochelatin synthase HTH_31 PF13560.6 ACT02323.1 - 0.0023 18.2 0.0 0.0061 16.9 0.0 1.8 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 ACT02323.1 - 0.016 15.2 1.7 0.024 14.7 0.0 2.1 3 1 0 3 3 3 0 Helix-turn-helix HTH_IclR PF09339.10 ACT02323.1 - 0.028 14.2 0.9 1.2 8.9 0.1 2.3 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_17 PF12728.7 ACT02323.1 - 0.1 12.8 1.6 0.19 12.0 0.1 2.2 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_23 PF13384.6 ACT02323.1 - 0.17 11.7 0.9 0.88 9.4 0.2 2.4 3 0 0 3 3 3 0 Homeodomain-like domain Sigma70_r4 PF04545.16 ACT02323.1 - 2.5 7.7 6.3 4.1 7.0 0.3 3.1 3 1 1 4 4 4 0 Sigma-70, region 4 MttA_Hcf106 PF02416.16 ACT02324.1 - 2.9e-19 68.1 0.0 3.2e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 mttA/Hcf106 family Mntp PF02659.15 ACT02325.1 - 9.3e-19 67.7 24.5 3e-15 56.3 13.5 2.0 1 1 1 2 2 2 2 Putative manganese efflux pump MFS_1 PF07690.16 ACT02326.1 - 7.8e-33 113.9 86.5 3.4e-30 105.2 52.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily EVI2A PF05399.11 ACT02326.1 - 6.3 6.3 6.8 6.1 6.4 0.6 2.6 3 0 0 3 3 3 0 Ectropic viral integration site 2A protein (EVI2A) Cupin_2 PF07883.11 ACT02327.1 - 9.3e-11 41.3 0.4 1.3e-10 40.8 0.4 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACT02327.1 - 2.5e-06 27.4 0.3 3.3e-06 27.1 0.3 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 ACT02327.1 - 0.0012 18.5 0.1 0.0021 17.7 0.1 1.4 1 1 0 1 1 1 1 Cupin Cupin_7 PF12973.7 ACT02327.1 - 0.06 13.3 0.0 0.083 12.8 0.0 1.4 1 1 0 1 1 1 0 ChrR Cupin-like domain Cupin_3 PF05899.12 ACT02327.1 - 0.088 12.5 0.3 6.2 6.6 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF861) ADH_N PF08240.12 ACT02328.1 - 3.8e-30 104.0 5.7 3.8e-30 104.0 5.7 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ACT02328.1 - 4.3e-21 75.2 0.0 6.9e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ACT02328.1 - 1.1e-07 33.0 0.0 1.9e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ACT02328.1 - 1.3e-07 31.1 0.0 2.2e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ACT02328.1 - 2.3e-05 23.8 0.0 4.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ACT02328.1 - 0.002 18.5 0.0 0.0036 17.7 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_2 PF03446.15 ACT02328.1 - 0.0061 16.7 0.2 0.014 15.6 0.1 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ThiF PF00899.21 ACT02328.1 - 0.013 14.8 3.1 1.2 8.5 2.4 2.2 1 1 1 2 2 2 0 ThiF family 3HCDH_N PF02737.18 ACT02328.1 - 0.032 14.1 0.1 0.069 13.0 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 ACT02328.1 - 0.081 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Shikimate_DH PF01488.20 ACT02328.1 - 0.096 12.8 0.0 0.24 11.5 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DUF4702 PF15774.5 ACT02328.1 - 0.17 10.8 0.0 0.25 10.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4702) Pyr_redox PF00070.27 ACT02328.1 - 0.18 12.4 0.8 2.8 8.6 0.4 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NADH_4Fe-4S PF10589.9 ACT02328.1 - 0.34 11.0 2.7 0.89 9.7 2.7 1.7 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region TetR_C_8 PF14278.6 ACT02329.1 - 2.9e-15 56.2 0.1 8.3e-15 54.8 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulator C-terminal region TetR_N PF00440.23 ACT02329.1 - 1.7e-10 40.5 0.0 2.9e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_Tnp_1_2 PF13022.6 ACT02329.1 - 0.04 14.1 0.1 0.075 13.2 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase HTH_40 PF14493.6 ACT02329.1 - 0.093 13.2 0.0 0.49 10.9 0.0 2.1 1 1 0 1 1 1 0 Helix-turn-helix domain Glycos_transf_4 PF00953.21 ACT02330.1 - 3.6e-31 108.3 17.5 3.6e-31 108.3 17.5 1.9 3 0 0 3 3 3 1 Glycosyl transferase family 4 Spore_YhaL PF14147.6 ACT02330.1 - 5.3 6.8 6.0 4.1 7.2 1.2 2.9 3 0 0 3 3 3 0 Sporulation protein YhaL SBP_bac_1 PF01547.25 ACT02332.1 - 3.2e-33 116.0 21.5 3.2e-33 116.0 21.5 1.9 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT02332.1 - 2.4e-06 27.1 0.2 0.01 15.3 0.0 2.5 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein Alpha_GJ PF03229.13 ACT02332.1 - 1.3 9.6 6.6 2.5 8.7 6.6 1.4 1 0 0 1 1 1 0 Alphavirus glycoprotein J GTA_TIM PF13547.6 ACT02333.1 - 4.9e-05 22.8 2.0 0.018 14.4 0.5 2.8 1 1 1 2 2 2 2 GTA TIM-barrel-like domain BPD_transp_1 PF00528.22 ACT02334.1 - 9.4e-14 51.6 15.0 9.4e-14 51.6 15.0 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02335.1 - 2.5e-14 53.4 20.0 6.9e-14 52.0 19.2 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component NAC PF01849.18 ACT02335.1 - 0.16 12.0 0.0 0.51 10.3 0.0 1.9 1 0 0 1 1 1 0 NAC domain DUF872 PF05915.12 ACT02335.1 - 9 6.5 8.1 7 6.9 0.7 2.9 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF872) Response_reg PF00072.24 ACT02336.1 - 3.7e-23 81.8 0.1 1e-22 80.4 0.1 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02336.1 - 7.9e-19 67.7 0.0 5e-18 65.2 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02336.1 - 1.6e-18 66.3 0.0 9.8e-08 31.9 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT02336.1 - 0.00017 21.9 0.9 0.00052 20.3 0.1 2.2 2 1 1 3 3 3 1 GGDEF-like domain FeoB_Cyto PF17910.1 ACT02336.1 - 1.5 9.4 7.5 23 5.6 0.0 3.7 2 1 1 3 3 3 0 FeoB cytosolic helical domain His_kinase PF06580.13 ACT02337.1 - 4.5e-21 75.0 0.4 1.3e-20 73.5 0.4 1.8 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT02337.1 - 4.9e-20 72.4 8.6 1.1e-19 71.2 8.6 1.6 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 ACT02337.1 - 5.3e-13 49.1 0.0 1.5e-12 47.7 0.0 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT02337.1 - 6.1e-10 39.6 0.0 2.1e-09 37.9 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT02337.1 - 0.011 15.7 0.0 0.027 14.4 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 ACT02337.1 - 0.019 14.9 0.0 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 GHKL domain HemY_N PF07219.13 ACT02337.1 - 0.041 14.1 4.5 1.7 8.9 0.4 2.4 2 0 0 2 2 2 0 HemY protein N-terminus ArlS_N PF18719.1 ACT02337.1 - 1.2 9.4 8.1 0.18 12.0 0.5 2.9 3 0 0 3 3 3 0 ArlS sensor domain Peripla_BP_3 PF13377.6 ACT02338.1 - 1.9e-32 112.9 0.0 2.8e-32 112.4 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT02338.1 - 5.1e-15 55.6 0.0 6.5e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT02338.1 - 1.6e-10 40.6 0.0 3.6e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_10 PF04967.12 ACT02338.1 - 0.014 15.2 0.0 0.53 10.1 0.0 2.4 2 0 0 2 2 2 0 HTH DNA binding domain Phage_CI_repr PF07022.13 ACT02338.1 - 0.039 14.0 0.0 0.06 13.4 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain PXB PF12828.7 ACT02338.1 - 0.04 13.9 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 PX-associated HTH_Crp_2 PF13545.6 ACT02338.1 - 0.041 13.8 0.0 0.091 12.8 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_31 PF13560.6 ACT02338.1 - 0.12 12.7 0.0 3.1 8.2 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_22 PF13309.6 ACT02338.1 - 0.14 12.3 0.1 0.68 10.1 0.0 2.2 2 0 0 2 2 2 0 HTH domain YdaS_antitoxin PF15943.5 ACT02338.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DDE_Tnp_1_6 PF13751.6 ACT02339.1 - 4.8e-30 104.4 0.1 1.2e-29 103.1 0.1 1.7 1 0 0 1 1 1 1 Transposase DDE domain DUF772 PF05598.11 ACT02339.1 - 7.4e-20 70.7 0.2 4e-19 68.4 0.2 2.2 2 0 0 2 2 2 1 Transposase domain (DUF772) DDE_Tnp_1 PF01609.21 ACT02339.1 - 1.8e-16 60.4 0.5 2e-15 57.1 0.5 2.3 1 1 0 1 1 1 1 Transposase DDE domain EndIII_4Fe-2S PF10576.9 ACT02339.1 - 0.5 10.8 1.6 0.84 10.1 1.6 1.4 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III DUF1690 PF07956.11 ACT02339.1 - 0.66 10.4 6.6 1.7 9.0 6.6 1.7 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF1840 PF08895.11 ACT02339.1 - 1.5 9.2 4.5 2.8 8.3 1.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1840) Peptidase_S15 PF02129.18 ACT02340.1 - 0.079 12.5 0.1 4 7.0 0.0 2.0 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Fez1 PF06818.15 ACT02341.1 - 0.0026 18.2 7.0 0.0034 17.9 7.0 1.2 1 0 0 1 1 1 1 Fez1 Ric8 PF10165.9 ACT02341.1 - 0.0084 15.2 1.8 0.01 14.9 1.8 1.2 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn DUF3139 PF11337.8 ACT02341.1 - 0.011 16.4 2.9 0.02 15.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Atg14 PF10186.9 ACT02341.1 - 0.032 13.3 3.6 0.041 13.0 3.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Toxin-JAB1 PF15659.6 ACT02341.1 - 0.09 13.1 0.4 3.4 8.1 0.0 2.8 3 1 0 3 3 3 0 JAB-like toxin 1 FAM76 PF16046.5 ACT02341.1 - 0.15 11.4 8.0 0.27 10.6 8.0 1.4 1 0 0 1 1 1 0 FAM76 protein TelA PF05816.11 ACT02341.1 - 0.6 9.1 13.7 0.29 10.2 0.3 2.1 1 1 0 2 2 2 0 Toxic anion resistance protein (TelA) Endonuc_Holl PF10107.9 ACT02341.1 - 0.92 9.3 10.5 0.15 11.9 5.6 1.8 1 1 1 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Peptidase_S49_N PF08496.10 ACT02341.1 - 1.5 8.9 9.7 1.2 9.1 8.3 1.5 1 1 0 1 1 1 0 Peptidase family S49 N-terminal AAA_23 PF13476.6 ACT02341.1 - 2 8.9 12.7 10 6.6 9.1 2.1 2 0 0 2 2 2 0 AAA domain LapA_dom PF06305.11 ACT02341.1 - 3.3 7.6 5.6 0.63 9.9 0.4 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain KIP1 PF07765.12 ACT02341.1 - 5.2 7.3 10.7 1.9 8.7 5.0 2.9 2 2 1 3 3 3 0 KIP1-like protein Cu_amine_oxidN1 PF07833.11 ACT02342.1 - 1.9e-11 44.3 0.0 3.5e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase N-terminal domain Peptidase_Prp PF04327.12 ACT02344.1 - 1.9e-17 63.3 0.2 2.7e-17 62.8 0.2 1.2 1 0 0 1 1 1 1 Cysteine protease Prp Peripla_BP_3 PF13377.6 ACT02348.1 - 3.7e-22 79.4 0.1 7.9e-22 78.3 0.1 1.6 2 0 0 2 2 2 1 Periplasmic binding protein-like domain LacI PF00356.21 ACT02348.1 - 1.8e-15 56.4 0.2 7e-15 54.5 0.2 2.1 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_1 PF00532.21 ACT02348.1 - 6e-12 45.6 0.0 8.8e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT02348.1 - 0.0023 17.6 0.0 0.0036 16.9 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein domain CEP44 PF15007.6 ACT02348.1 - 0.0036 17.4 0.0 0.0065 16.6 0.0 1.4 1 0 0 1 1 1 1 Centrosomal spindle body, CEP44 TetR_N PF00440.23 ACT02348.1 - 0.04 13.7 0.0 0.096 12.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_3 PF01381.22 ACT02348.1 - 0.094 12.8 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix HTH_31 PF13560.6 ACT02348.1 - 0.097 13.0 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HAD_2 PF13419.6 ACT02349.1 - 1.3e-17 64.5 0.0 1.5e-17 64.2 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT02349.1 - 1.9e-10 40.6 0.0 3e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ACT02349.1 - 8.6e-10 39.2 0.0 1.3e-09 38.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ACT02349.1 - 0.056 13.6 0.0 0.15 12.2 0.0 1.9 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase ABC_tran PF00005.27 ACT02350.1 - 6.9e-30 104.4 0.0 1.2e-29 103.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 ACT02350.1 - 1.1e-17 64.3 1.1 2e-17 63.5 0.5 1.7 2 0 0 2 2 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_22 PF13401.6 ACT02350.1 - 5.9e-07 29.8 0.1 3.4e-06 27.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 ACT02350.1 - 1.6e-05 24.5 0.2 2.8e-05 23.7 0.2 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT02350.1 - 2.4e-05 24.3 0.1 0.012 15.4 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ACT02350.1 - 0.00059 19.8 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA PF00004.29 ACT02350.1 - 0.0007 20.0 0.1 0.0084 16.5 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 ACT02350.1 - 0.00071 19.0 0.1 0.053 12.9 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein AAA_16 PF13191.6 ACT02350.1 - 0.00094 19.6 0.1 0.002 18.5 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 ACT02350.1 - 0.0018 18.3 0.1 0.0034 17.3 0.1 1.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea PRK PF00485.18 ACT02350.1 - 0.0077 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family ATP-synt_ab PF00006.25 ACT02350.1 - 0.014 15.1 0.0 0.03 14.0 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain ATPase PF06745.13 ACT02350.1 - 0.014 14.8 0.1 0.16 11.3 0.0 2.1 2 0 0 2 2 2 0 KaiC AAA_30 PF13604.6 ACT02350.1 - 0.014 15.1 0.0 0.14 11.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ACT02350.1 - 0.032 13.8 0.0 2.4 7.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ACT02350.1 - 0.033 13.4 0.3 0.097 11.8 0.1 1.7 2 0 0 2 2 2 0 NB-ARC domain MobB PF03205.14 ACT02350.1 - 0.035 14.0 0.0 0.7 9.8 0.0 2.5 2 1 1 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.6 ACT02350.1 - 0.061 13.8 0.9 0.13 12.7 0.9 1.8 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ACT02350.1 - 0.064 13.5 0.0 0.44 10.8 0.0 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF2075 PF09848.9 ACT02350.1 - 0.068 12.4 0.0 0.62 9.2 0.0 1.9 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 ACT02350.1 - 0.072 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 ACT02350.1 - 0.077 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 ACT02350.1 - 0.18 11.5 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 ACT02350.1 - 0.24 11.1 1.3 3 7.6 0.1 2.4 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_13 PF13166.6 ACT02350.1 - 0.84 8.2 2.5 1.6 7.2 0.2 2.2 2 1 1 3 3 3 0 AAA domain ABC_tran PF00005.27 ACT02351.1 - 8.3e-26 91.1 0.0 1.2e-25 90.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 ACT02351.1 - 9.6e-17 61.3 0.1 2e-16 60.2 0.1 1.6 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 ACT02351.1 - 1.9e-07 31.2 0.1 1e-05 25.6 0.0 2.1 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ACT02351.1 - 0.0018 18.5 1.4 0.036 14.4 1.4 2.1 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 ACT02351.1 - 0.027 13.9 0.5 0.18 11.2 0.1 2.1 2 0 0 2 2 2 0 Bacterial TniB protein BPD_transp_1 PF00528.22 ACT02352.1 - 2.2e-23 83.0 12.5 2.2e-23 83.0 12.5 1.7 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 ACT02352.1 - 2.8e-13 49.6 0.3 2.8e-13 49.6 0.3 2.2 2 0 0 2 2 2 1 N-terminal TM domain of oligopeptide transport permease C BPD_transp_1 PF00528.22 ACT02353.1 - 1.2e-28 100.1 11.3 1.2e-28 100.1 11.3 2.1 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Gemini_mov PF01708.16 ACT02353.1 - 0.096 12.5 0.2 0.096 12.5 0.2 3.3 3 1 0 3 3 3 0 Geminivirus putative movement protein SBP_bac_5 PF00496.22 ACT02354.1 - 2.8e-62 210.9 8.7 4.1e-62 210.3 8.7 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle BPD_transp_1 PF00528.22 ACT02355.1 - 1.5e-16 60.7 13.8 1.5e-16 60.7 13.8 2.0 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component ApoO PF09769.9 ACT02355.1 - 0.12 12.3 1.1 0.47 10.4 0.4 2.1 2 0 0 2 2 2 0 Apolipoprotein O DUF4293 PF14126.6 ACT02355.1 - 1.5 9.1 11.5 0.033 14.4 1.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) BPD_transp_1 PF00528.22 ACT02356.1 - 1.4e-16 60.8 18.0 1.4e-16 60.8 18.0 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Dpy19 PF10034.9 ACT02356.1 - 0.0023 16.3 4.8 0.0023 16.3 4.8 1.9 3 0 0 3 3 3 1 Q-cell neuroblast polarisation DUF996 PF06195.13 ACT02356.1 - 5.5 7.3 26.3 0.093 13.0 8.5 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF996) SBP_bac_8 PF13416.6 ACT02357.1 - 3.8e-33 115.5 6.9 3.8e-33 115.5 6.9 1.4 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02357.1 - 1.6e-30 107.2 7.8 3.3e-30 106.1 7.8 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Response_reg PF00072.24 ACT02358.1 - 1.5e-20 73.4 0.1 4.6e-20 71.9 0.1 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02358.1 - 1.8e-20 73.0 1.4 2.4e-20 72.6 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02358.1 - 1.6e-19 69.5 0.4 3e-10 39.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_Crp_2 PF13545.6 ACT02358.1 - 0.031 14.2 0.5 1.8 8.6 0.0 2.9 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain Peptidase_S66 PF02016.15 ACT02358.1 - 0.049 13.7 0.5 0.34 11.0 0.0 2.5 3 0 0 3 3 3 0 LD-carboxypeptidase N-terminal domain FeoB_Cyto PF17910.1 ACT02358.1 - 0.29 11.7 2.2 11 6.6 0.1 3.2 3 1 0 3 3 3 0 FeoB cytosolic helical domain His_kinase PF06580.13 ACT02359.1 - 7e-22 77.6 0.5 2e-21 76.1 0.5 1.8 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT02359.1 - 2.9e-10 40.3 1.8 2.9e-10 40.3 1.8 1.6 2 0 0 2 2 2 1 Cache domain HAMP PF00672.25 ACT02359.1 - 1.9e-09 37.7 0.1 4.8e-09 36.5 0.1 1.7 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT02359.1 - 9.4e-09 35.8 0.0 6e-08 33.2 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT02359.1 - 0.0078 16.0 0.0 0.063 13.1 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF948 PF06103.11 ACT02359.1 - 0.15 12.4 2.0 0.86 9.9 2.0 2.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF4870 PF09685.10 ACT02359.1 - 0.45 10.6 4.8 0.4 10.8 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4870) EamA PF00892.20 ACT02360.1 - 2.7e-33 115.0 44.3 1.9e-17 63.7 16.2 2.0 2 0 0 2 2 2 2 EamA-like transporter family EptA_B_N PF08019.12 ACT02360.1 - 6.1 6.7 15.5 0.033 14.1 5.5 2.3 2 2 0 2 2 2 0 Phosphoethanolamine transferase EptA/EptB LysR_substrate PF03466.20 ACT02361.1 - 2.1e-36 125.3 0.0 2.5e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT02361.1 - 1.8e-16 59.8 0.0 2.8e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family SBP_bac_1 PF01547.25 ACT02362.1 - 2.2e-13 50.8 7.7 2.2e-13 50.8 7.7 1.8 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT02363.1 - 7.6e-12 45.3 18.4 2.2e-11 43.8 18.4 1.9 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component MPS-4 PF17523.2 ACT02363.1 - 0.88 9.7 3.6 0.59 10.3 0.9 2.1 2 0 0 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 BPD_transp_1 PF00528.22 ACT02364.1 - 2e-13 50.5 10.4 2e-13 50.5 10.4 2.6 1 1 1 3 3 3 1 Binding-protein-dependent transport system inner membrane component HTH_18 PF12833.7 ACT02365.1 - 9.7e-23 80.2 0.0 1.5e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02365.1 - 1.9e-15 56.5 1.2 4.2e-07 29.9 0.0 2.7 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT02365.1 - 2.6e-05 23.9 0.2 4e-05 23.2 0.2 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACT02365.1 - 0.004 17.0 0.0 0.0061 16.5 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_3 PF01381.22 ACT02365.1 - 0.0051 16.8 0.0 0.016 15.3 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_Crp_2 PF13545.6 ACT02365.1 - 0.015 15.2 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_23 PF13384.6 ACT02365.1 - 0.078 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain IMS PF00817.20 ACT02367.1 - 1.9e-41 141.5 0.0 3.5e-41 140.7 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 ACT02367.1 - 6.3e-16 59.1 0.0 1.3e-15 58.1 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 ACT02367.1 - 9.5e-07 28.8 0.0 2.4e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif DUF2515 PF10720.9 ACT02368.1 - 9.6e-126 419.1 0.0 1.2e-125 418.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2515) SRAP PF02586.14 ACT02369.1 - 1.3e-68 230.8 0.0 1.5e-68 230.6 0.0 1.0 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) Glyco_hydr_30_2 PF14587.6 ACT02369.1 - 0.11 12.1 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 O-Glycosyl hydrolase family 30 SpoVIF PF14069.6 ACT02370.1 - 4.6e-20 71.2 1.2 5.4e-20 70.9 1.2 1.1 1 0 0 1 1 1 1 Stage VI sporulation protein F FliL PF03748.14 ACT02370.1 - 0.068 13.8 0.3 0.078 13.6 0.3 1.1 1 0 0 1 1 1 0 Flagellar basal body-associated protein FliL Helicase_C PF00271.31 ACT02371.1 - 6.6e-25 87.6 0.0 5.2e-19 68.6 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 ACT02371.1 - 3.2e-19 69.4 0.2 6.9e-19 68.3 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecG_wedge PF17191.4 ACT02371.1 - 3e-18 66.0 0.0 5.9e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 RecG wedge domain ResIII PF04851.15 ACT02371.1 - 1e-08 35.4 0.0 2.8e-08 34.0 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 ACT02371.1 - 0.0024 17.2 0.1 0.0045 16.3 0.1 1.4 1 0 0 1 1 1 1 SecA DEAD-like domain ERCC3_RAD25_C PF16203.5 ACT02371.1 - 0.01 15.0 0.0 0.025 13.8 0.0 1.6 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase PIF1 PF05970.14 ACT02371.1 - 0.06 12.5 0.1 0.087 12.0 0.1 1.2 1 0 0 1 1 1 0 PIF1-like helicase AAA_30 PF13604.6 ACT02371.1 - 0.083 12.6 0.6 0.2 11.3 0.1 1.8 2 0 0 2 2 2 0 AAA domain DegV PF02645.16 ACT02372.1 - 9e-85 284.4 0.1 1e-84 284.2 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein, DegV family COG1307 Dak1_2 PF13684.6 ACT02373.1 - 5.5e-112 373.9 0.0 9e-112 373.2 0.0 1.3 1 0 0 1 1 1 1 Dihydroxyacetone kinase family Dak2 PF02734.17 ACT02373.1 - 1.8e-41 142.0 0.2 3.9e-41 140.8 0.2 1.6 1 0 0 1 1 1 1 DAK2 domain S4_2 PF13275.6 ACT02373.1 - 0.074 12.9 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 S4 domain DUF3597 PF12200.8 ACT02373.1 - 0.95 10.0 3.1 6.3 7.4 0.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Asp23 PF03780.13 ACT02374.1 - 6.1e-33 113.5 4.0 6.9e-33 113.3 4.0 1.0 1 0 0 1 1 1 1 Asp23 family, cell envelope-related function DUF4931 PF16285.5 ACT02374.1 - 0.0095 15.3 0.1 0.0096 15.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4931) Ribosomal_L28 PF00830.19 ACT02375.1 - 1.5e-21 76.4 3.6 1.8e-21 76.1 3.6 1.0 1 0 0 1 1 1 1 Ribosomal L28 family T2SS-T3SS_pil_N PF13629.6 ACT02375.1 - 0.02 14.6 0.1 0.11 12.2 0.0 1.9 1 1 1 2 2 2 0 Pilus formation protein N terminal region SpoV PF08183.11 ACT02376.1 - 1.5e-17 63.2 3.6 1.6e-17 63.1 3.6 1.0 1 0 0 1 1 1 1 Stage V sporulation protein family FtsX PF02687.21 ACT02377.1 - 1.2 9.6 11.9 2.9 8.4 11.9 1.6 1 1 0 1 1 1 0 FtsX-like permease family PhoR PF11808.8 ACT02377.1 - 4.7 7.7 8.7 0.45 11.0 1.9 1.9 1 1 1 2 2 2 0 Phosphate regulon sensor protein PhoR Ribul_P_3_epim PF00834.19 ACT02378.1 - 1.1e-85 286.0 0.1 1.3e-85 285.9 0.1 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family His_biosynth PF00977.21 ACT02378.1 - 0.00051 19.6 0.1 0.02 14.4 0.1 2.1 2 0 0 2 2 2 1 Histidine biosynthesis protein PcrB PF01884.17 ACT02378.1 - 0.00073 19.1 1.0 0.054 12.9 0.5 2.1 1 1 1 2 2 2 2 PcrB family PEP_mutase PF13714.6 ACT02378.1 - 0.004 16.6 0.4 0.31 10.5 0.0 2.8 1 1 2 3 3 3 1 Phosphoenolpyruvate phosphomutase RsgA_GTPase PF03193.16 ACT02379.1 - 7.1e-59 198.5 0.0 9.3e-59 198.1 0.0 1.1 1 0 0 1 1 1 1 RsgA GTPase RsgA_N PF16745.5 ACT02379.1 - 2.1e-22 78.6 0.1 3.4e-22 77.9 0.1 1.4 1 0 0 1 1 1 1 RsgA N-terminal domain MMR_HSR1 PF01926.23 ACT02379.1 - 1.1e-07 31.9 0.0 3.2e-07 30.4 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 ACT02379.1 - 9.8e-05 22.0 0.1 0.029 14.0 0.0 2.2 1 1 1 2 2 2 2 Ras family AAA_29 PF13555.6 ACT02379.1 - 0.0016 18.2 0.0 0.003 17.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 ACT02379.1 - 0.0045 17.5 0.1 0.0084 16.6 0.1 1.4 1 0 0 1 1 1 1 ABC transporter FeoB_N PF02421.18 ACT02379.1 - 0.0071 15.9 0.0 1.9 8.0 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B NACHT PF05729.12 ACT02379.1 - 0.069 13.1 0.0 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 ACT02379.1 - 0.099 13.0 0.1 0.21 12.0 0.1 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 ACT02379.1 - 0.1 13.1 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ACT02379.1 - 0.15 11.6 0.0 0.5 9.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 ACT02380.1 - 2.4e-59 200.9 0.1 3.1e-59 200.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ACT02380.1 - 2.6e-43 148.2 0.0 3.4e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PASTA PF03793.19 ACT02380.1 - 9.1e-30 102.3 6.3 2.2e-10 40.2 0.7 3.8 3 0 0 3 3 3 3 PASTA domain APH PF01636.23 ACT02380.1 - 8.2e-07 29.2 2.3 0.0054 16.7 0.8 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ACT02380.1 - 5.2e-05 22.7 0.0 9.3e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 ACT02380.1 - 0.00022 20.9 1.2 0.00043 19.9 0.7 1.6 1 1 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ACT02380.1 - 0.0023 16.8 0.1 0.14 10.9 0.1 2.2 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ACT02380.1 - 0.0032 16.5 0.1 0.0048 15.9 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ACT02380.1 - 0.0048 16.3 0.9 0.0089 15.4 0.9 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ACT02380.1 - 0.014 14.5 0.1 0.028 13.5 0.1 1.5 2 0 0 2 2 2 0 Seadornavirus VP7 YrbL-PhoP_reg PF10707.9 ACT02380.1 - 0.024 14.2 0.1 0.089 12.3 0.1 1.9 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Fructosamin_kin PF03881.14 ACT02380.1 - 0.085 12.1 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase PIP49_C PF12260.8 ACT02380.1 - 0.086 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 KIND PF16474.5 ACT02380.1 - 0.18 11.7 0.1 1.1 9.1 0.0 2.3 2 1 0 2 2 2 0 Kinase non-catalytic C-lobe domain PP2C PF00481.21 ACT02381.1 - 2e-19 70.3 1.0 3.5e-13 49.8 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 ACT02381.1 - 1.3e-18 67.4 1.0 2e-18 66.8 1.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ACT02381.1 - 1.5e-07 31.5 7.1 8.7e-07 29.0 7.1 1.8 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) DUF3247 PF11607.8 ACT02381.1 - 0.0037 17.5 0.1 0.0085 16.3 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3247) PTS_IIA PF02255.16 ACT02381.1 - 0.019 15.0 1.2 2.2 8.4 0.1 2.3 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit DsrH PF04077.12 ACT02381.1 - 0.045 13.9 1.3 0.27 11.4 0.1 2.6 2 1 1 3 3 3 0 DsrH like protein Radical_SAM PF04055.21 ACT02382.1 - 3.8e-17 63.2 0.0 6e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 ACT02382.1 - 2.2e-06 27.8 0.0 4.5e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 ACT02382.1 - 0.0098 16.2 0.0 0.022 15.0 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Methyltr_RsmB-F PF01189.17 ACT02383.1 - 9e-60 201.7 0.0 1.3e-59 201.3 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F NusB PF01029.18 ACT02383.1 - 1.9e-34 118.8 0.1 3.1e-34 118.1 0.1 1.4 1 0 0 1 1 1 1 NusB family Methyltransf_31 PF13847.6 ACT02383.1 - 2.2e-06 27.6 0.0 3.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmF_N PF17125.5 ACT02383.1 - 9.3e-06 26.1 0.0 1.8e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 ACT02383.1 - 1.1e-05 25.6 0.0 2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 ACT02383.1 - 0.0062 15.9 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Fibrillarin PF01269.17 ACT02383.1 - 0.029 13.5 0.0 0.05 12.7 0.0 1.3 1 0 0 1 1 1 0 Fibrillarin Methyltransf_11 PF08241.12 ACT02383.1 - 0.032 14.9 0.0 0.25 12.0 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 ACT02383.1 - 0.1 12.1 0.0 1.5 8.2 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase Parvo_NS1 PF01057.17 ACT02383.1 - 0.24 10.4 0.0 0.38 9.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Formyl_trans_N PF00551.19 ACT02384.1 - 1e-43 149.2 0.0 1.3e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 ACT02384.1 - 8.8e-28 96.5 0.0 1.3e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Glyco_transf_4 PF13439.6 ACT02384.1 - 0.17 11.9 0.0 0.27 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Pep_deformylase PF01327.21 ACT02385.1 - 5.5e-52 175.6 0.0 6.7e-52 175.3 0.0 1.0 1 0 0 1 1 1 1 Polypeptide deformylase PriA_3primeBD PF17764.1 ACT02386.1 - 5.5e-28 96.7 0.0 1.6e-27 95.2 0.0 1.9 2 0 0 2 2 1 1 3′ DNA-binding domain (3′BD) PriA_C PF18074.1 ACT02386.1 - 7.9e-18 65.1 0.0 8.8e-17 61.7 0.0 2.9 2 1 0 2 2 2 1 Primosomal protein N C-terminal domain ResIII PF04851.15 ACT02386.1 - 2.7e-15 56.8 0.0 4.2e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ACT02386.1 - 2e-14 53.8 0.0 4.3e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ACT02386.1 - 7.7e-13 48.8 0.0 1.2e-08 35.2 0.0 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain PriA_CRR PF18319.1 ACT02386.1 - 6e-12 45.3 9.6 6e-12 45.3 9.6 2.8 3 0 0 3 3 3 1 PriA DNA helicase Cys-rich region (CRR) domain PIF1 PF05970.14 ACT02386.1 - 0.0088 15.2 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase AAA_19 PF13245.6 ACT02386.1 - 0.012 15.9 0.0 0.028 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ACT02386.1 - 0.016 15.6 3.8 0.019 15.4 0.6 2.8 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ACT02386.1 - 0.03 14.6 0.4 0.14 12.4 0.0 2.3 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 ACT02386.1 - 0.054 12.8 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin TrwB_AAD_bind PF10412.9 ACT02386.1 - 0.072 12.0 0.1 0.44 9.4 0.0 2.0 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ATPase_2 PF01637.18 ACT02386.1 - 0.075 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea zinc-ribbons_6 PF07191.12 ACT02386.1 - 0.075 13.0 4.2 0.16 11.9 4.2 1.5 1 0 0 1 1 1 0 zinc-ribbons AAA_30 PF13604.6 ACT02386.1 - 0.12 12.0 0.2 0.29 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ACT02386.1 - 0.12 11.5 0.0 0.25 10.5 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain TIR PF01582.20 ACT02386.1 - 0.18 11.6 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 TIR domain Flavi_DEAD PF07652.14 ACT02386.1 - 0.19 11.7 0.0 0.83 9.6 0.0 2.0 1 1 0 1 1 1 0 Flavivirus DEAD domain Zn_ribbon_SprT PF17283.2 ACT02386.1 - 0.28 11.1 8.6 0.089 12.7 3.8 2.5 1 1 1 2 2 2 0 SprT-like zinc ribbon domain DNA_RNApol_7kD PF03604.13 ACT02386.1 - 1.2 8.9 4.5 2.9 7.6 1.2 2.4 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 ACT02386.1 - 1.7 8.7 8.7 58 3.8 8.7 2.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DFP PF04127.15 ACT02387.1 - 2.9e-74 248.9 4.1 3.8e-72 242.0 0.7 2.1 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Flavoprotein PF02441.19 ACT02387.1 - 4.1e-45 153.4 0.9 7.6e-45 152.5 0.9 1.5 1 0 0 1 1 1 1 Flavoprotein Epimerase PF01370.21 ACT02387.1 - 0.0071 15.8 0.2 1.1 8.7 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family CDC48_N PF02359.18 ACT02387.1 - 0.0074 16.4 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain F420_oxidored PF03807.17 ACT02387.1 - 0.017 15.7 5.8 0.79 10.3 0.1 3.9 4 1 0 4 4 4 0 NADP oxidoreductase coenzyme F420-dependent PALP PF00291.25 ACT02387.1 - 0.028 13.9 4.6 0.31 10.4 0.4 2.8 2 1 1 3 3 3 0 Pyridoxal-phosphate dependent enzyme adh_short_C2 PF13561.6 ACT02387.1 - 0.038 13.5 6.6 1.2 8.6 1.5 3.4 3 1 0 3 3 3 0 Enoyl-(Acyl carrier protein) reductase Glyco_trans_4_4 PF13579.6 ACT02387.1 - 0.048 14.1 0.5 11 6.4 0.2 2.7 2 1 0 2 2 2 0 Glycosyl transferase 4-like domain GDP_Man_Dehyd PF16363.5 ACT02387.1 - 0.12 11.8 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF188 PF02639.14 ACT02387.1 - 0.12 12.0 1.2 0.21 11.2 0.2 1.9 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 DBD_HTH PF18430.1 ACT02387.1 - 0.8 9.5 4.5 14 5.5 0.0 3.9 4 1 1 5 5 5 0 Putative DNA-binding domain DnaJ PF00226.31 ACT02388.1 - 8.3e-06 25.8 0.1 1.9e-05 24.7 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_21 PF09976.9 ACT02388.1 - 0.13 11.9 2.5 0.25 11.1 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain MSC PF09402.10 ACT02388.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain LUD_dom PF02589.15 ACT02390.1 - 6.9e-27 94.4 0.0 1.1e-26 93.7 0.0 1.3 2 0 0 2 2 2 1 LUD domain LUD_dom PF02589.15 ACT02391.1 - 1.2e-54 184.9 0.3 1.7e-54 184.4 0.3 1.3 1 0 0 1 1 1 1 LUD domain Fer4_8 PF13183.6 ACT02391.1 - 2.3e-11 43.9 0.7 5.1e-11 42.9 0.7 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain DUF3390 PF11870.8 ACT02391.1 - 9.9e-07 29.0 0.0 2.4e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3390) Fer4_17 PF13534.6 ACT02391.1 - 1.6e-06 28.5 1.0 3.2e-06 27.6 1.0 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ACT02391.1 - 3.5e-06 27.0 6.2 0.00014 21.9 7.5 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 ACT02391.1 - 3.6e-06 26.6 13.7 0.0027 17.4 4.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 ACT02391.1 - 6e-06 26.7 4.3 2.1e-05 25.0 4.3 1.9 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 ACT02391.1 - 5e-05 23.2 11.3 0.00065 19.6 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 ACT02391.1 - 0.00014 21.8 11.8 0.023 14.7 3.2 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 ACT02391.1 - 0.00016 21.9 8.8 0.005 17.2 0.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 ACT02391.1 - 0.00027 21.0 7.8 0.018 15.2 9.5 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 ACT02391.1 - 0.00032 21.4 12.2 0.11 13.5 3.8 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 ACT02391.1 - 0.004 18.1 9.3 0.092 13.7 9.9 2.5 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 ACT02391.1 - 0.011 15.9 4.4 0.29 11.3 0.8 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 ACT02391.1 - 0.035 14.3 0.8 1.5 9.1 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_20 PF14691.6 ACT02391.1 - 0.25 11.1 1.1 15 5.4 0.0 2.4 2 0 0 2 2 2 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_13 PF13370.6 ACT02391.1 - 1.5 9.4 8.2 1.2 9.8 1.3 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 ACT02391.1 - 2.2 9.2 4.2 16 6.4 1.1 2.6 2 0 0 2 2 2 0 4Fe-4S dicluster domain CCG PF02754.16 ACT02392.1 - 2.3e-28 98.2 0.0 6.9e-13 48.6 0.0 2.3 2 0 0 2 2 2 2 Cysteine-rich domain DeoRC PF00455.22 ACT02393.1 - 8.6e-54 181.8 0.2 1.1e-53 181.4 0.2 1.1 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 ACT02393.1 - 5.4e-18 64.5 1.0 1e-17 63.6 1.0 1.5 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain MarR PF01047.22 ACT02393.1 - 4.3e-05 23.4 0.2 9.2e-05 22.3 0.2 1.5 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 ACT02393.1 - 5e-05 23.2 0.2 0.0001 22.2 0.2 1.5 1 0 0 1 1 1 1 HTH domain DUF4423 PF14394.6 ACT02393.1 - 0.0004 20.1 0.1 0.00067 19.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) GntR PF00392.21 ACT02393.1 - 0.0021 17.7 1.6 0.0034 17.0 0.7 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family PaaX PF07848.12 ACT02393.1 - 0.0026 17.9 0.5 0.0054 16.9 0.5 1.5 1 0 0 1 1 1 1 PaaX-like protein HTH_29 PF13551.6 ACT02393.1 - 0.0043 17.0 0.2 0.0095 15.9 0.2 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Crp_2 PF13545.6 ACT02393.1 - 0.0054 16.7 0.4 0.013 15.4 0.4 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Put_DNA-bind_N PF06971.13 ACT02393.1 - 0.0074 16.3 0.1 0.018 15.0 0.1 1.7 1 0 0 1 1 1 1 Putative DNA-binding protein N-terminus MarR_2 PF12802.7 ACT02393.1 - 0.0097 15.8 0.5 0.021 14.7 0.5 1.5 1 0 0 1 1 1 1 MarR family HTH_28 PF13518.6 ACT02393.1 - 0.019 15.1 0.4 0.041 14.0 0.4 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_5 PF01022.20 ACT02393.1 - 0.027 14.3 0.0 0.057 13.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HxlR PF01638.17 ACT02393.1 - 0.028 14.3 0.1 0.23 11.4 0.0 2.2 2 0 0 2 2 2 0 HxlR-like helix-turn-helix HTH_36 PF13730.6 ACT02393.1 - 0.092 12.7 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Fe_dep_repress PF01325.19 ACT02393.1 - 0.1 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain FeoC PF09012.10 ACT02393.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 FeoC like transcriptional regulator DUF1993 PF09351.10 ACT02393.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) HTH_AsnC-type PF13404.6 ACT02393.1 - 0.38 10.6 3.7 0.29 11.0 0.7 2.4 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain RNA_pol_Rpb6 PF01192.22 ACT02394.1 - 1.1e-12 47.7 0.1 1.3e-12 47.5 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb6 Guanylate_kin PF00625.21 ACT02395.1 - 2e-48 164.5 0.0 2.3e-48 164.3 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.6 ACT02395.1 - 2.3e-07 31.4 0.0 3.5e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ACT02395.1 - 0.0035 17.8 0.1 0.0059 17.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ACT02395.1 - 0.0046 17.1 0.0 0.046 13.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT02395.1 - 0.0049 16.8 0.1 0.0092 15.9 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 ACT02395.1 - 0.017 15.7 0.0 0.037 14.5 0.0 1.8 1 1 0 1 1 1 0 ABC transporter Rad17 PF03215.15 ACT02395.1 - 0.027 14.4 0.0 0.041 13.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 ACT02395.1 - 0.029 14.4 0.1 0.062 13.4 0.0 1.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 ACT02395.1 - 0.033 14.6 0.0 0.043 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ADK PF00406.22 ACT02395.1 - 0.035 14.2 0.2 4.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Adenylate kinase AAA PF00004.29 ACT02395.1 - 0.056 13.9 0.2 0.25 11.8 0.0 2.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TipAS PF07739.13 ACT02395.1 - 0.062 13.9 0.0 0.91 10.1 0.0 2.0 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain AAA_22 PF13401.6 ACT02395.1 - 0.071 13.4 0.0 0.14 12.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 ACT02395.1 - 0.071 12.9 0.0 0.94 9.3 0.0 2.2 1 1 1 2 2 2 0 Deoxynucleoside kinase Thymidylate_kin PF02223.17 ACT02395.1 - 0.079 12.6 0.0 0.39 10.4 0.0 1.9 1 1 1 2 2 2 0 Thymidylate kinase DUF370 PF04025.12 ACT02396.1 - 2e-37 127.1 1.1 2.2e-37 127.0 1.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF370) S-methyl_trans PF02574.16 ACT02397.1 - 1e-54 186.2 0.0 1.7e-54 185.4 0.0 1.4 1 0 0 1 1 1 1 Homocysteine S-methyltransferase MTHFR PF02219.17 ACT02397.1 - 1.4e-22 80.4 0.0 2.2e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase PEP_mutase PF13714.6 ACT02397.1 - 0.022 14.2 1.3 0.39 10.1 0.0 3.2 3 1 1 4 4 4 0 Phosphoenolpyruvate phosphomutase DAP_epimerase PF01678.19 ACT02398.1 - 2.4e-62 208.5 0.7 2.2e-30 105.3 0.1 2.0 2 0 0 2 2 2 2 Diaminopimelate epimerase PhzC-PhzF PF02567.16 ACT02398.1 - 9.3e-05 22.0 0.0 0.00014 21.4 0.0 1.5 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein E1-E2_ATPase PF00122.20 ACT02399.1 - 2.8e-54 183.4 1.4 2.8e-54 183.4 1.4 2.7 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ACT02399.1 - 4.4e-53 179.7 5.4 4.4e-53 179.7 5.4 1.7 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ACT02399.1 - 1.1e-26 94.4 1.8 3.1e-26 93.0 1.8 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ACT02399.1 - 1.1e-21 76.7 0.1 2.1e-21 75.8 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ACT02399.1 - 8.3e-20 70.3 0.1 2.4e-19 68.8 0.1 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ACT02399.1 - 1.3e-05 25.1 0.3 0.0095 15.7 0.2 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT02399.1 - 2.1e-05 25.0 0.0 5.2e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Tannase PF07519.11 ACT02399.1 - 0.029 13.3 0.1 0.044 12.7 0.1 1.1 1 0 0 1 1 1 0 Tannase and feruloyl esterase POTRA_1 PF08478.10 ACT02399.1 - 0.1 12.9 0.0 0.52 10.7 0.0 2.1 2 0 0 2 2 2 0 POTRA domain, FtsQ-type PH_4 PF15404.6 ACT02399.1 - 0.2 11.4 0.0 0.64 9.8 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain FbpA PF05833.11 ACT02400.1 - 6.1e-152 506.5 0.1 7.3e-152 506.3 0.1 1.0 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 ACT02400.1 - 1.9e-11 44.5 0.0 3.6e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 NFACT protein RNA binding domain NFACT-R_2 PF18297.1 ACT02400.1 - 2.1e-07 31.1 0.0 8.7e-07 29.1 0.0 2.0 1 0 0 1 1 1 1 NFACT protein RNA binding domain DUF3891 PF13030.6 ACT02400.1 - 0.025 14.3 0.3 0.051 13.3 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3891) COG2 PF06148.11 ACT02400.1 - 0.026 14.6 0.4 0.064 13.4 0.4 1.5 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 TFIIB_C_1 PF18542.1 ACT02400.1 - 0.028 14.4 1.4 0.44 10.6 0.3 2.4 2 0 0 2 2 2 0 Transcription factor IIB C-terminal module 1 NLPC_P60 PF00877.19 ACT02401.1 - 1.3e-12 47.6 0.5 3.3e-12 46.4 0.5 1.6 1 1 0 1 1 1 1 NlpC/P60 family CHAP PF05257.16 ACT02401.1 - 1e-05 26.0 0.1 2.3e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 CHAP domain Peptidase_C92 PF05708.12 ACT02401.1 - 1.6e-05 25.1 0.0 0.072 13.2 0.0 2.1 2 0 0 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family PHP PF02811.19 ACT02402.1 - 2.3e-12 47.5 0.0 3.5e-12 46.9 0.0 1.5 1 1 0 1 1 1 1 PHP domain PHP_C PF13263.6 ACT02402.1 - 0.0044 16.7 0.0 0.058 13.2 0.0 2.8 4 0 0 4 4 4 1 PHP-associated LysR_substrate PF03466.20 ACT02403.1 - 1.9e-46 158.1 0.0 3e-46 157.4 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT02403.1 - 7e-23 80.3 0.1 1.4e-22 79.4 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 ACT02403.1 - 5e-10 38.8 0.0 7.3e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 PBP superfamily domain MarR_2 PF12802.7 ACT02403.1 - 0.12 12.3 0.1 0.4 10.6 0.0 1.9 2 0 0 2 2 2 0 MarR family PBP_like_2 PF12849.7 ACT02403.1 - 0.14 11.8 0.0 0.28 10.8 0.0 1.6 1 1 0 1 1 1 0 PBP superfamily domain DUF2129 PF09902.9 ACT02405.1 - 7.3e-30 102.9 2.1 8.5e-30 102.6 2.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2129) Com_YlbF PF06133.11 ACT02406.1 - 5.5e-20 71.9 1.1 6.3e-20 71.8 1.1 1.0 1 0 0 1 1 1 1 Control of competence regulator ComK, YlbF/YmcA MapZ_EC1 PF18041.1 ACT02406.1 - 0.0087 16.3 0.4 0.011 16.0 0.4 1.1 1 0 0 1 1 1 1 MapZ extracellular domain 1 Enkurin PF13864.6 ACT02406.1 - 0.029 14.8 0.4 0.04 14.4 0.4 1.2 1 0 0 1 1 1 0 Calmodulin-binding GreA_GreB_N PF03449.15 ACT02406.1 - 0.33 11.1 3.9 0.3 11.3 0.8 2.2 2 1 0 2 2 2 0 Transcription elongation factor, N-terminal Helicase_C_3 PF13625.6 ACT02407.1 - 1.8e-06 28.1 0.0 4.9e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ifi-6-16 PF06140.13 ACT02407.1 - 0.059 13.3 0.4 4.2 7.3 0.0 2.3 2 0 0 2 2 2 0 Interferon-induced 6-16 family ERCC3_RAD25_C PF16203.5 ACT02408.1 - 9.1e-48 162.6 0.0 1.3e-47 162.1 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 ACT02408.1 - 3.5e-37 127.4 0.0 7.1e-37 126.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT02408.1 - 5.1e-15 55.9 0.0 7.7e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ACT02408.1 - 4e-12 46.4 0.0 8.3e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ACT02408.1 - 3.2e-06 26.1 0.0 5.2e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 ACT02408.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase CBS PF00571.28 ACT02409.1 - 4.1e-24 84.8 3.3 1.5e-13 51.0 0.2 2.1 2 0 0 2 2 2 2 CBS domain FAD_binding_4 PF01565.23 ACT02409.1 - 0.0068 16.1 0.1 0.011 15.5 0.1 1.4 1 1 0 1 1 1 1 FAD binding domain Peptidase_M20 PF01546.28 ACT02410.1 - 7.2e-29 101.0 0.7 9e-29 100.7 0.7 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ACT02410.1 - 1.1e-10 41.3 0.1 4.1e-10 39.6 0.0 1.8 2 0 0 2 2 2 1 Peptidase dimerisation domain YugN PF08868.10 ACT02411.1 - 1.7e-11 44.2 0.0 2e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 YugN-like family FTSW_RODA_SPOVE PF01098.19 ACT02412.1 - 8e-96 321.2 29.7 9.2e-96 321.0 29.7 1.0 1 0 0 1 1 1 1 Cell cycle protein Asp23 PF03780.13 ACT02413.1 - 2.6e-35 121.1 4.9 2.9e-35 120.9 4.9 1.0 1 0 0 1 1 1 1 Asp23 family, cell envelope-related function Dodecin PF07311.12 ACT02413.1 - 0.13 12.6 1.6 2.7 8.3 0.3 2.2 2 0 0 2 2 2 0 Dodecin Na_Ca_ex PF01699.24 ACT02414.1 - 3.9e-31 108.1 43.3 4.3e-16 59.2 15.6 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein LrgA PF03788.14 ACT02414.1 - 0.00013 21.9 5.4 0.00013 21.9 5.4 4.0 3 1 0 4 4 4 1 LrgA family DUF1980 PF09323.10 ACT02414.1 - 0.6 10.0 5.2 0.11 12.3 0.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1980) DUF1507 PF07408.11 ACT02415.1 - 1.7e-40 136.8 0.9 1.9e-40 136.6 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1507) DUF2680 PF10925.8 ACT02415.1 - 0.056 13.5 0.1 0.42 10.6 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2680) PTS-HPr PF00381.19 ACT02416.1 - 5.7e-08 32.9 0.1 7.4e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 PTS HPr component phosphorylation site Peptidase_M29 PF02073.15 ACT02417.1 - 3.1e-56 190.9 0.0 3.9e-56 190.6 0.0 1.1 1 0 0 1 1 1 1 Thermophilic metalloprotease (M29) AAA_23 PF13476.6 ACT02418.1 - 0.0019 18.7 0.1 0.0024 18.4 0.1 1.1 1 0 0 1 1 1 1 AAA domain DUF4249 PF14054.6 ACT02418.1 - 0.032 13.9 0.1 0.069 12.8 0.0 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4249) LPAM_1 PF08139.12 ACT02418.1 - 2.5 8.8 4.3 5.3 7.7 4.3 1.5 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site GGDEF PF00990.21 ACT02419.1 - 7.2e-42 142.9 0.0 2e-41 141.4 0.0 1.8 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GAF_3 PF13492.6 ACT02419.1 - 3e-21 76.1 0.0 2.4e-13 50.6 0.0 3.3 3 0 0 3 3 3 2 GAF domain GAF_2 PF13185.6 ACT02419.1 - 1.6e-20 73.8 0.0 1.8e-13 51.0 0.0 3.5 3 0 0 3 3 3 2 GAF domain GAF PF01590.26 ACT02419.1 - 2e-18 67.3 0.0 2.7e-14 54.0 0.0 2.8 3 0 0 3 3 3 2 GAF domain SpoVT_C PF15714.5 ACT02419.1 - 0.049 13.7 0.0 0.28 11.2 0.0 2.2 2 0 0 2 2 2 0 Stage V sporulation protein T C-terminal, transcription factor DUF3369 PF11849.8 ACT02419.1 - 0.069 13.3 1.0 4.6 7.4 0.0 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF3369) GARS_C PF02843.16 ACT02419.1 - 0.076 13.3 0.0 1.9 8.8 0.1 2.9 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, C domain GGDEF_2 PF17853.1 ACT02419.1 - 0.091 13.0 0.1 0.49 10.7 0.1 2.2 2 0 0 2 2 2 0 GGDEF-like domain CDP-OH_P_transf PF01066.21 ACT02419.1 - 0.11 13.3 0.0 6.9 7.5 0.0 2.5 2 0 0 2 2 2 0 CDP-alcohol phosphatidyltransferase Ribosomal_S4 PF00163.19 ACT02420.1 - 8.5e-30 103.5 1.0 1.4e-29 102.8 1.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 ACT02420.1 - 1.1e-20 73.1 0.1 2.1e-20 72.2 0.1 1.5 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 ACT02420.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 S4 domain Methyltransf_25 PF13649.6 ACT02421.1 - 5.2e-19 68.7 0.0 1e-18 67.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT02421.1 - 2.3e-18 66.6 0.0 4.1e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT02421.1 - 5.1e-18 65.3 0.0 9e-18 64.5 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT02421.1 - 1e-13 51.5 0.0 1.8e-13 50.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT02421.1 - 1e-13 51.8 0.0 2.4e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ACT02421.1 - 3.5e-09 36.3 0.0 6.2e-09 35.5 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 ACT02421.1 - 1.5e-08 34.6 0.0 2.6e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ACT02421.1 - 2.6e-07 30.4 0.0 4.5e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 ACT02421.1 - 4e-06 26.0 0.0 7.3e-06 25.1 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) NodS PF05401.11 ACT02421.1 - 9.8e-05 22.1 0.0 0.00014 21.5 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) CMAS PF02353.20 ACT02421.1 - 0.00013 21.4 0.1 0.00033 20.0 0.1 1.9 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 ACT02421.1 - 0.0022 17.5 0.1 0.0053 16.2 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 ACT02421.1 - 0.0067 16.0 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW UPF0020 PF01170.18 ACT02421.1 - 0.0081 15.9 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 TehB PF03848.14 ACT02421.1 - 0.034 13.6 0.0 0.058 12.8 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 ACT02421.1 - 0.072 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 ACT02421.1 - 0.087 11.9 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TPMT PF05724.11 ACT02421.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Band_7 PF01145.25 ACT02422.1 - 2.2e-25 89.7 0.1 2.2e-25 89.7 0.1 3.1 2 1 1 3 3 3 1 SPFH domain / Band 7 family Flot PF15975.5 ACT02422.1 - 8.7e-09 35.6 3.1 8.7e-09 35.6 3.1 4.9 3 2 1 4 4 4 1 Flotillin NfeD PF01957.18 ACT02423.1 - 9.4e-08 32.3 0.1 1.4e-07 31.7 0.1 1.3 1 0 0 1 1 1 1 NfeD-like C-terminal, partner-binding Transgly PF00912.22 ACT02425.1 - 4e-52 176.3 0.0 7.9e-52 175.3 0.0 1.5 1 0 0 1 1 1 1 Transglycosylase Transpeptidase PF00905.22 ACT02425.1 - 2.7e-34 118.8 1.1 5.2e-34 117.8 1.1 1.4 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain fn3 PF00041.21 ACT02425.1 - 1.1e-06 28.9 1.7 0.018 15.4 0.1 2.5 2 0 0 2 2 2 2 Fibronectin type III domain fn3_4 PF16794.5 ACT02425.1 - 0.08 12.9 0.0 21 5.1 0.0 2.7 2 0 0 2 2 2 0 Fibronectin-III type domain AMP-binding PF00501.28 ACT02426.1 - 1.9e-93 313.3 0.0 2.3e-93 313.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ACT02426.1 - 1.4e-23 83.6 0.3 3.2e-23 82.5 0.3 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acetyltransf_1 PF00583.25 ACT02427.1 - 0.00061 20.0 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT02427.1 - 0.0018 18.6 0.1 0.0053 17.2 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACT02427.1 - 0.091 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Hist_deacetyl PF00850.19 ACT02428.1 - 1.4e-76 258.0 0.8 1.7e-76 257.7 0.8 1.1 1 0 0 1 1 1 1 Histone deacetylase domain PNP_UDP_1 PF01048.20 ACT02429.1 - 1.3e-50 171.9 1.4 1.4e-50 171.7 1.4 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily PUA PF01472.20 ACT02429.1 - 0.012 15.5 0.1 0.047 13.7 0.1 2.0 1 0 0 1 1 1 0 PUA domain NUP PF06516.11 ACT02429.1 - 0.033 13.4 0.1 0.072 12.3 0.0 1.5 2 0 0 2 2 2 0 Purine nucleoside permease (NUP) Peripla_BP_3 PF13377.6 ACT02430.1 - 2e-37 129.1 0.0 5.2e-37 127.7 0.0 1.7 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT02430.1 - 5.1e-29 101.6 0.3 6.3e-29 101.3 0.3 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT02430.1 - 6e-23 81.7 0.4 8.1e-23 81.3 0.4 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain LacI PF00356.21 ACT02430.1 - 3.1e-21 74.9 0.6 7.7e-21 73.6 0.6 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_26 PF13443.6 ACT02430.1 - 0.034 14.6 0.0 0.073 13.5 0.0 1.5 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain TrmB PF01978.19 ACT02430.1 - 0.046 13.6 1.7 1.9 8.4 0.1 3.5 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB HTH_3 PF01381.22 ACT02430.1 - 0.082 13.0 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix HTH_38 PF13936.6 ACT02430.1 - 0.12 12.2 0.1 0.44 10.4 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 ACT02430.1 - 0.14 12.0 0.1 0.89 9.4 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain VanZ PF04892.12 ACT02432.1 - 1.5e-13 51.5 0.9 2.6e-13 50.7 0.9 1.3 1 1 0 1 1 1 1 VanZ like family YGGT PF02325.17 ACT02432.1 - 0.15 12.5 0.1 0.15 12.5 0.1 2.3 3 0 0 3 3 3 0 YGGT family DJ-1_PfpI PF01965.24 ACT02433.1 - 1.8e-44 151.5 0.0 2e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family PEP-utilizers_C PF02896.18 ACT02434.1 - 5.5e-111 370.4 0.0 1.7e-110 368.7 0.0 1.7 2 0 0 2 2 2 1 PEP-utilising enzyme, TIM barrel domain PEP-utilisers_N PF05524.13 ACT02434.1 - 1.7e-30 105.5 0.2 5.2e-29 100.8 0.2 2.6 3 0 0 3 3 3 1 PEP-utilising enzyme, N-terminal PEP-utilizers PF00391.23 ACT02434.1 - 7.8e-20 70.4 0.1 1.9e-19 69.1 0.1 1.7 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain HpcH_HpaI PF03328.14 ACT02434.1 - 0.0057 15.8 0.6 0.014 14.5 0.1 1.9 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family PTS_EIIC PF02378.18 ACT02435.1 - 6.5e-56 189.7 31.3 6.5e-56 189.7 31.3 1.7 2 0 0 2 2 2 1 Phosphotransferase system, EIIC PTS_EIIA_1 PF00358.20 ACT02435.1 - 1e-44 151.4 0.1 1.5e-44 150.8 0.1 1.3 1 0 0 1 1 1 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 PTS_EIIB PF00367.20 ACT02435.1 - 4.9e-11 41.9 0.1 9.9e-11 40.9 0.1 1.5 1 0 0 1 1 1 1 phosphotransferase system, EIIB FixS PF03597.15 ACT02435.1 - 3.9 7.3 11.4 0.06 13.1 1.5 3.2 3 0 0 3 3 3 0 Cytochrome oxidase maturation protein cbb3-type CoA_binding_2 PF13380.6 ACT02436.1 - 4.4e-44 149.7 0.1 5.3e-44 149.4 0.1 1.1 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.19 ACT02436.1 - 0.00057 20.5 0.0 0.00083 20.0 0.0 1.2 1 0 0 1 1 1 1 CoA binding domain PAS_8 PF13188.7 ACT02436.1 - 0.048 13.7 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 PAS domain EPSP_synthase PF00275.20 ACT02437.1 - 1.2e-91 307.5 0.0 1.4e-91 307.3 0.0 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) SKI PF01202.22 ACT02438.1 - 1e-40 139.4 0.1 1.2e-40 139.3 0.1 1.0 1 0 0 1 1 1 1 Shikimate kinase AAA_18 PF13238.6 ACT02438.1 - 2.1e-08 34.7 0.0 3e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ACT02438.1 - 2.6e-06 27.7 0.1 7.8e-06 26.1 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACT02438.1 - 2.2e-05 24.7 0.0 4.3e-05 23.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 ACT02438.1 - 0.00068 19.8 0.1 0.0059 16.8 0.1 2.1 1 1 0 1 1 1 1 Cytidylate kinase-like family Cytidylate_kin PF02224.18 ACT02438.1 - 0.00098 18.9 0.1 0.0098 15.6 0.0 2.2 1 1 0 2 2 2 1 Cytidylate kinase AAA_28 PF13521.6 ACT02438.1 - 0.0021 18.3 0.2 0.0052 17.1 0.1 1.7 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ACT02438.1 - 0.003 17.9 0.2 0.0059 17.0 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.6 ACT02438.1 - 0.009 16.4 0.1 0.052 14.0 0.1 2.1 1 1 0 1 1 1 1 AAA domain CoaE PF01121.20 ACT02438.1 - 0.0097 15.6 0.1 0.04 13.6 0.0 1.9 1 1 0 2 2 2 1 Dephospho-CoA kinase CPT PF07931.12 ACT02438.1 - 0.015 15.1 0.2 0.4 10.5 0.1 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_5 PF07728.14 ACT02438.1 - 0.016 15.2 0.1 0.071 13.1 0.1 2.0 1 1 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ACT02438.1 - 0.016 15.7 0.0 0.025 15.1 0.0 1.4 1 1 0 1 1 1 0 ABC transporter dNK PF01712.19 ACT02438.1 - 0.025 14.4 0.0 0.047 13.5 0.0 1.5 1 0 0 1 1 1 0 Deoxynucleoside kinase TsaE PF02367.17 ACT02438.1 - 0.028 14.4 0.0 0.056 13.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 ACT02438.1 - 0.035 13.8 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 ACT02438.1 - 0.04 14.3 0.0 0.054 13.9 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) 6PF2K PF01591.18 ACT02438.1 - 0.064 12.6 0.0 0.098 11.9 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_30 PF13604.6 ACT02438.1 - 0.066 12.9 0.7 1 9.1 0.3 2.1 1 1 1 2 2 2 0 AAA domain tRNA_m1G_MT PF01746.21 ACT02438.1 - 0.099 12.3 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase 6PGD PF00393.19 ACT02440.1 - 7.2e-134 445.7 0.0 9.6e-134 445.3 0.0 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ACT02440.1 - 1.7e-53 181.0 0.1 2.5e-53 180.5 0.1 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 ACT02440.1 - 0.0004 20.5 0.1 0.0007 19.7 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 ACT02440.1 - 0.0016 17.8 0.0 0.0035 16.7 0.0 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ACT02440.1 - 0.0051 17.4 0.1 0.012 16.2 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 ACT02440.1 - 0.0059 16.5 0.0 0.0094 15.9 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_11 PF14833.6 ACT02440.1 - 0.11 12.7 0.0 0.54 10.5 0.0 2.2 3 0 0 3 3 3 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase IlvN PF07991.12 ACT02440.1 - 0.12 11.9 0.1 0.36 10.4 0.0 1.9 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain SH2 PF00017.24 ACT02441.1 - 0.075 13.1 0.2 0.63 10.2 0.0 2.5 1 1 1 2 2 2 0 SH2 domain tRNA-synt_2b PF00587.25 ACT02442.1 - 3.4e-48 164.0 0.0 5.1e-48 163.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 ACT02442.1 - 1.8e-26 92.6 0.1 3.4e-26 91.7 0.1 1.4 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain HGTP_anticodon PF03129.20 ACT02442.1 - 7.9e-20 70.8 0.2 4.1e-19 68.5 0.1 2.3 2 0 0 2 2 2 1 Anticodon binding domain AAA_22 PF13401.6 ACT02442.1 - 0.0059 16.9 0.0 1.9 8.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF1054 PF06335.12 ACT02443.1 - 1.2e-82 276.6 0.0 1.4e-82 276.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1054) ACR_tran PF00873.19 ACT02444.1 - 3.4e-187 624.3 39.5 4e-187 624.0 39.5 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 ACT02444.1 - 5.1e-12 45.4 48.6 3.9e-07 29.3 15.4 3.8 3 1 1 4 4 4 2 MMPL family SecD_SecF PF02355.16 ACT02444.1 - 4.7e-07 29.4 39.5 2.8e-05 23.6 11.6 2.7 3 0 0 3 3 3 2 Protein export membrane protein PLAC9 PF15205.6 ACT02444.1 - 0.11 13.0 0.4 0.25 11.7 0.4 1.6 1 0 0 1 1 1 0 Placenta-specific protein 9 ABC_tran PF00005.27 ACT02445.1 - 1.5e-28 100.0 0.0 2.1e-28 99.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02445.1 - 4.2e-14 53.1 1.2 3e-09 37.1 0.2 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system KdpD PF02702.17 ACT02445.1 - 0.0008 18.9 0.1 0.0011 18.5 0.1 1.2 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain AAA_22 PF13401.6 ACT02445.1 - 0.0027 18.0 0.0 0.0062 16.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 ACT02445.1 - 0.0038 16.7 0.0 0.26 10.7 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 ACT02445.1 - 0.0081 16.6 0.2 0.44 11.0 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ACT02445.1 - 0.0091 16.5 0.1 0.015 15.8 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ACT02445.1 - 0.0098 15.6 0.1 0.025 14.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT02445.1 - 0.013 15.2 0.3 0.027 14.2 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT02445.1 - 0.016 15.6 0.2 0.028 14.8 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ACT02445.1 - 0.024 14.5 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_24 PF13479.6 ACT02445.1 - 0.047 13.4 0.3 0.78 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ACT02445.1 - 0.077 12.7 0.2 1.4 8.6 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.14 ACT02445.1 - 0.094 12.7 0.1 1.6 8.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 ACT02445.1 - 0.095 12.3 0.2 0.64 9.6 0.0 2.2 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 ACT02445.1 - 0.12 12.3 0.4 3.3 7.6 0.1 2.2 2 0 0 2 2 2 0 NTPase Mg_chelatase PF01078.21 ACT02445.1 - 0.16 11.3 0.2 1.7 8.0 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 ACT02445.1 - 0.21 10.7 0.3 2 7.5 0.1 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA_33 PF13671.6 ACT02445.1 - 0.24 11.6 1.2 0.74 10.0 1.2 2.1 1 1 0 1 1 1 0 AAA domain ABC2_membrane_3 PF12698.7 ACT02446.1 - 5.8e-34 117.7 13.0 7.2e-34 117.4 13.0 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 ACT02446.1 - 6.3e-30 104.2 22.8 2.7e-28 98.9 18.8 2.1 2 0 0 2 2 2 2 ABC-2 type transporter ABC2_membrane_2 PF12679.7 ACT02446.1 - 3.5e-14 52.8 11.5 4.9e-14 52.3 11.5 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 ACT02446.1 - 0.00025 21.1 7.7 0.00025 21.1 7.7 1.8 2 0 0 2 2 2 1 ABC-2 family transporter protein CcmB PF03379.13 ACT02446.1 - 0.022 14.2 7.3 0.012 15.1 4.6 1.8 1 1 1 2 2 2 0 CcmB protein SBP_bac_3 PF00497.20 ACT02446.1 - 0.038 13.4 0.0 0.06 12.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 NodS PF05401.11 ACT02446.1 - 0.19 11.3 0.0 0.93 9.1 0.0 1.9 2 0 0 2 2 2 0 Nodulation protein S (NodS) TetR_N PF00440.23 ACT02447.1 - 1.2e-15 57.0 0.5 2e-15 56.3 0.5 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_Tnp_1_2 PF13022.6 ACT02447.1 - 0.00075 19.7 0.1 0.0024 18.0 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix of insertion element transposase TetR_C_7 PF14246.6 ACT02447.1 - 0.00099 19.1 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 AefR-like transcriptional repressor, C-terminal domain Sigma70_r4_2 PF08281.12 ACT02447.1 - 0.0058 16.3 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 TetR_C_11 PF16859.5 ACT02447.1 - 0.012 15.9 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain HTH_40 PF14493.6 ACT02447.1 - 0.06 13.8 1.7 0.43 11.1 0.3 2.7 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 ACT02447.1 - 0.072 12.9 0.0 0.26 11.1 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain CENP-B_N PF04218.13 ACT02447.1 - 0.12 12.0 0.0 0.41 10.3 0.0 1.9 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain YitT_membrane PF02588.15 ACT02448.1 - 4.2e-37 127.5 16.5 4.6e-37 127.4 16.5 1.0 1 0 0 1 1 1 1 Uncharacterised 5xTM membrane BCR, YitT family COG1284 MFS_1 PF07690.16 ACT02449.1 - 1.1e-57 195.6 42.3 2.1e-55 188.1 33.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT02449.1 - 1.2e-13 50.7 11.4 1.2e-13 50.7 11.4 2.9 1 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 ACT02449.1 - 8.4e-09 35.2 17.6 7.9e-06 25.4 5.1 2.1 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 ACT02449.1 - 2.1e-08 33.5 8.1 2.1e-08 33.5 8.1 2.9 1 1 1 2 2 2 1 MFS_1 like family MFS_3 PF05977.13 ACT02449.1 - 2.9e-06 26.0 8.7 4.2e-06 25.4 8.7 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector OATP PF03137.20 ACT02449.1 - 2.1 6.5 23.2 2.7 6.2 0.2 4.3 3 1 1 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family OKR_DC_1 PF01276.20 ACT02450.1 - 3.1e-105 352.3 0.0 1.4e-104 350.2 0.0 1.8 1 1 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Aminotran_1_2 PF00155.21 ACT02450.1 - 4e-12 46.0 0.1 5e-11 42.4 0.1 2.0 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ACT02450.1 - 1.6e-11 43.8 0.3 4.4e-10 39.1 0.3 2.1 1 1 0 1 1 1 1 Aminotransferase class-V OKR_DC_1_C PF03711.15 ACT02450.1 - 2e-11 44.3 0.0 6.4e-11 42.7 0.0 1.8 2 0 0 2 2 2 1 Orn/Lys/Arg decarboxylase, C-terminal domain DegT_DnrJ_EryC1 PF01041.17 ACT02450.1 - 6.9e-10 38.8 1.1 1e-09 38.2 1.1 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SepSecS PF05889.13 ACT02450.1 - 4.7e-07 28.8 0.1 7.2e-07 28.2 0.1 1.2 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 ACT02450.1 - 4.7e-07 29.4 0.1 1e-06 28.2 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase DUF1885 PF08968.10 ACT02451.1 - 6.9e-57 191.2 0.0 7.7e-57 191.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1885) Peptidase_M14 PF00246.24 ACT02451.1 - 0.062 13.1 0.1 1.4 8.6 0.0 2.0 1 1 1 2 2 2 0 Zinc carboxypeptidase DUF1292 PF06949.11 ACT02452.1 - 1.9e-11 44.7 7.7 1.9e-11 44.7 7.7 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF1292) CBM_48 PF02922.18 ACT02452.1 - 0.14 12.5 0.1 0.2 12.0 0.1 1.3 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Cu_amine_oxidN1 PF07833.11 ACT02453.1 - 9.5e-08 32.4 0.3 2.1e-07 31.3 0.3 1.7 1 1 0 1 1 1 1 Copper amine oxidase N-terminal domain DUF1189 PF06691.11 ACT02453.1 - 0.28 10.7 4.3 0.23 11.0 2.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1189) Lactamase_B_2 PF12706.7 ACT02455.1 - 1.8e-15 57.0 0.1 2.3e-15 56.7 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACT02455.1 - 8.3e-10 39.0 1.4 1.8e-09 37.9 1.4 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 ACT02455.1 - 9.2e-05 22.0 0.0 0.00014 21.4 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ACT02455.1 - 0.032 14.1 0.0 0.063 13.2 0.0 1.5 1 1 0 1 1 1 0 Beta-lactamase superfamily domain DUF3892 PF13031.6 ACT02456.1 - 1e-18 67.7 0.5 1.2e-18 67.5 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3892) DUF2524 PF10732.9 ACT02458.1 - 1.1e-05 25.7 0.2 1.2e-05 25.5 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2524) Med9 PF07544.13 ACT02458.1 - 0.0037 17.3 0.9 0.0054 16.8 0.9 1.4 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 FlxA PF14282.6 ACT02458.1 - 0.0062 16.5 0.2 0.0076 16.2 0.2 1.2 1 0 0 1 1 1 1 FlxA-like protein DUF2680 PF10925.8 ACT02458.1 - 0.13 12.3 0.6 0.21 11.6 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) Lipoprotein_15 PF03640.15 ACT02459.1 - 4.4e-29 99.8 2.6 9.5e-18 63.5 0.4 2.5 2 0 0 2 2 2 2 Secreted repeat of unknown function Copper-bind PF00127.20 ACT02459.1 - 9.7e-13 48.4 0.4 1e-11 45.1 0.4 2.3 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 ACT02459.1 - 2.3e-12 47.0 0.4 1.1e-11 44.8 0.2 2.0 2 0 0 2 2 2 1 Cupredoxin-like domain PepX_N PF09168.10 ACT02459.1 - 0.00047 20.6 0.0 0.0014 19.1 0.0 1.8 2 0 0 2 2 2 1 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal SLH PF00395.20 ACT02459.1 - 0.011 15.7 2.9 0.028 14.4 0.2 2.7 3 0 0 3 3 3 0 S-layer homology domain DUF3192 PF11399.8 ACT02459.1 - 0.12 12.3 0.0 0.44 10.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3192) Copper-bind PF00127.20 ACT02460.1 - 3.9e-10 40.0 0.3 6.2e-09 36.2 0.3 2.3 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 ACT02460.1 - 4.4e-09 36.4 0.2 1.1e-08 35.2 0.1 1.6 2 0 0 2 2 2 1 Cupredoxin-like domain PRCC PF10253.9 ACT02460.1 - 0.011 16.5 10.5 0.014 16.2 10.5 1.1 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF4969 PF16339.5 ACT02460.1 - 0.065 13.6 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4969) SOG2 PF10428.9 ACT02460.1 - 0.6 9.3 10.5 0.65 9.1 10.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Hamartin PF04388.12 ACT02460.1 - 2.6 6.6 9.2 3.1 6.3 9.2 1.2 1 0 0 1 1 1 0 Hamartin protein Ndc1_Nup PF09531.10 ACT02460.1 - 2.7 6.6 3.5 3 6.4 3.5 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MAP65_ASE1 PF03999.12 ACT02460.1 - 3.3 6.3 7.4 3.6 6.2 7.4 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Pneumo_att_G PF05539.11 ACT02460.1 - 4.6 6.7 9.8 6.2 6.3 9.8 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G CCSAP PF15748.5 ACT02460.1 - 7.8 6.6 12.1 11 6.1 12.1 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Sigma70_r2 PF04542.14 ACT02461.1 - 9.7e-16 57.3 1.0 9.7e-16 57.3 1.0 1.6 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT02461.1 - 1.7e-06 27.6 0.0 2.9e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT02461.1 - 6.1e-06 25.7 0.1 2e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACT02461.1 - 0.0001 22.3 0.2 0.00014 21.8 0.2 1.3 1 0 0 1 1 1 1 ECF sigma factor UPF0122 PF04297.14 ACT02461.1 - 0.0057 16.9 0.5 0.029 14.6 0.1 2.1 2 0 0 2 2 2 1 Putative helix-turn-helix protein, YlxM / p13 like SAVED PF18145.1 ACT02461.1 - 0.074 12.8 0.1 0.096 12.5 0.1 1.2 1 0 0 1 1 1 0 SMODS-associated and fused to various effectors sensor domain Terminase_5 PF06056.12 ACT02461.1 - 0.078 12.9 0.2 0.34 10.8 0.1 2.1 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) TPR_22 PF18833.1 ACT02461.1 - 0.13 12.4 0.4 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat RskA PF10099.9 ACT02462.1 - 1.6e-20 74.2 1.7 2.1e-20 73.8 1.7 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA zf-HC2 PF13490.6 ACT02462.1 - 3e-06 27.4 0.2 5.6e-06 26.5 0.2 1.4 1 0 0 1 1 1 1 Putative zinc-finger Glft2_N PF17994.1 ACT02462.1 - 0.045 13.7 0.0 0.068 13.1 0.0 1.3 1 0 0 1 1 1 0 Galactofuranosyltransferase 2 N-terminal zf-TFIIB PF13453.6 ACT02462.1 - 0.11 11.8 0.1 0.24 10.8 0.1 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger Cupin_2 PF07883.11 ACT02463.1 - 2.5e-17 62.3 1.3 3.6e-17 61.9 1.3 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACT02463.1 - 5.3e-05 23.1 0.4 5.3e-05 23.1 0.4 1.4 2 0 0 2 2 2 1 AraC-like ligand binding domain MannoseP_isomer PF01050.18 ACT02463.1 - 0.0012 18.8 0.2 0.0013 18.7 0.2 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase AraC_binding_2 PF14525.6 ACT02463.1 - 0.018 14.8 0.0 0.019 14.6 0.0 1.1 1 0 0 1 1 1 0 AraC-binding-like domain FdtA PF05523.11 ACT02463.1 - 0.019 14.7 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 WxcM-like, C-terminal DMSP_lyase PF16867.5 ACT02463.1 - 0.029 14.0 0.8 0.032 13.9 0.8 1.1 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase Cupin_1 PF00190.22 ACT02463.1 - 0.047 13.3 0.0 0.054 13.1 0.0 1.2 1 0 0 1 1 1 0 Cupin Cupin_3 PF05899.12 ACT02463.1 - 0.071 12.8 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Ectoine_synth PF06339.12 ACT02463.1 - 0.088 13.0 0.1 0.1 12.8 0.1 1.2 1 0 0 1 1 1 0 Ectoine synthase Response_reg PF00072.24 ACT02464.1 - 1.6e-26 92.7 0.2 3.7e-26 91.5 0.2 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02464.1 - 2.3e-21 75.8 0.9 1.1e-20 73.7 0.1 2.4 3 0 0 3 3 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02464.1 - 6.4e-18 64.4 1.1 1.7e-09 37.5 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family MarR_2 PF12802.7 ACT02464.1 - 2.5e-05 24.1 0.0 0.00081 19.2 0.0 2.5 2 0 0 2 2 2 1 MarR family HTH_3 PF01381.22 ACT02464.1 - 8.5e-05 22.5 0.0 0.04 14.0 0.0 3.3 3 0 0 3 3 3 1 Helix-turn-helix HTH_23 PF13384.6 ACT02464.1 - 0.00011 21.9 0.0 0.0046 16.7 0.0 3.0 3 0 0 3 3 3 1 Homeodomain-like domain HTH_24 PF13412.6 ACT02464.1 - 0.00026 20.5 0.0 0.082 12.5 0.0 3.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 ACT02464.1 - 0.0011 18.8 0.0 0.026 14.4 0.0 2.5 2 0 0 2 2 2 1 MarR family HTH_31 PF13560.6 ACT02464.1 - 0.0028 17.9 0.0 0.89 10.0 0.0 3.0 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_11 PF08279.12 ACT02464.1 - 0.0087 16.0 1.3 6.1 6.9 0.0 3.7 3 1 1 4 4 4 1 HTH domain UPF0122 PF04297.14 ACT02464.1 - 0.0093 16.2 0.9 0.039 14.2 0.9 2.1 1 0 0 1 1 1 1 Putative helix-turn-helix protein, YlxM / p13 like Sigma70_ECF PF07638.11 ACT02464.1 - 0.028 14.3 0.1 12 5.7 0.0 3.1 2 1 1 3 3 3 0 ECF sigma factor HTH_Tnp_4 PF13613.6 ACT02464.1 - 0.029 14.1 0.6 0.11 12.2 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease HTH_6 PF01418.17 ACT02464.1 - 0.032 14.2 0.0 0.12 12.3 0.0 2.1 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family HTH_28 PF13518.6 ACT02464.1 - 0.077 13.1 0.0 0.27 11.4 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma54_DBD PF04552.13 ACT02464.1 - 0.083 12.6 0.1 0.7 9.6 0.1 2.5 1 1 2 3 3 3 0 Sigma-54, DNA binding domain Mga PF05043.13 ACT02464.1 - 0.091 13.4 0.9 1.1 9.9 0.2 3.1 3 0 0 3 3 3 0 Mga helix-turn-helix domain Mor PF08765.11 ACT02464.1 - 0.092 12.7 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 Mor transcription activator family HTH_Tnp_ISL3 PF13542.6 ACT02464.1 - 0.11 12.0 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 His_kinase PF06580.13 ACT02465.1 - 1.3e-17 63.8 0.9 1.3e-17 63.8 0.9 2.3 1 1 1 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT02465.1 - 2.5e-09 37.3 6.9 2.5e-09 37.3 6.9 1.8 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACT02465.1 - 0.00017 22.0 0.0 0.00049 20.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT02465.1 - 0.0025 17.7 0.0 0.0051 16.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT02465.1 - 0.0031 17.8 0.1 0.0077 16.6 0.1 1.7 1 0 0 1 1 1 1 HAMP domain DUF3810 PF12725.7 ACT02465.1 - 0.0081 15.5 2.5 0.011 15.1 0.1 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF3810) DUF3139 PF11337.8 ACT02465.1 - 0.017 15.7 3.4 0.12 13.0 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) Comm PF15957.5 ACT02465.1 - 0.034 14.5 0.5 2 8.8 0.2 2.6 2 0 0 2 2 2 0 Commissureless SBP_bac_8 PF13416.6 ACT02466.1 - 5.5e-32 111.7 10.7 7.9e-32 111.2 10.7 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02466.1 - 3.9e-30 105.9 9.3 6e-30 105.3 9.3 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT02466.1 - 4.3e-05 23.0 0.1 0.0019 17.6 0.1 2.6 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT02466.1 - 0.0021 17.9 0.4 0.35 10.6 0.0 3.0 3 0 0 3 3 3 1 Bacterial extracellular solute-binding protein DUF508 PF04370.12 ACT02466.1 - 0.087 12.6 0.8 0.18 11.5 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF508) YSIRK_signal PF04650.17 ACT02466.1 - 0.23 11.3 1.8 0.38 10.7 1.8 1.3 1 0 0 1 1 1 0 YSIRK type signal peptide BPD_transp_1 PF00528.22 ACT02467.1 - 4.8e-19 68.8 17.4 4.8e-19 68.8 17.4 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02468.1 - 9.9e-15 54.7 21.0 9.9e-15 54.7 21.0 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component TTC5_OB PF16669.5 ACT02468.1 - 0.055 13.2 0.5 0.14 11.8 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat protein 5 OB fold domain Cation_efflux PF01545.21 ACT02470.1 - 1.4e-45 155.5 17.3 1.6e-45 155.3 17.3 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ACT02470.1 - 1.1e-18 67.1 0.8 1.7e-18 66.5 0.8 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter TatC PF00902.18 ACT02470.1 - 0.088 12.6 4.3 0.57 10.0 2.7 2.1 2 0 0 2 2 2 0 Sec-independent protein translocase protein (TatC) MIG-14_Wnt-bd PF06664.12 ACT02470.1 - 0.29 10.3 9.6 0.034 13.4 5.4 1.5 2 0 0 2 2 2 0 Wnt-binding factor required for Wnt secretion DUF3611 PF12263.8 ACT02470.1 - 0.42 10.5 9.7 0.038 13.9 3.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3611) DUF2721 PF11026.8 ACT02470.1 - 2.7 7.9 7.2 7.5 6.5 7.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Glycos_transf_2 PF00535.26 ACT02471.1 - 6.3e-21 74.9 0.0 9.1e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACT02471.1 - 7e-07 29.4 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_5 PF13712.6 ACT02471.1 - 0.0062 16.2 0.1 0.031 13.9 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family Glyco_tranf_2_2 PF10111.9 ACT02471.1 - 0.03 13.8 0.0 0.087 12.3 0.0 1.8 1 1 0 1 1 1 0 Glycosyltransferase like family 2 DUF3699 PF12480.8 ACT02471.1 - 0.07 13.3 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3699) NTP_transferase PF00483.23 ACT02472.1 - 1.2e-18 67.6 0.0 2.1e-18 66.8 0.0 1.3 1 1 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACT02472.1 - 3.7e-09 37.2 0.0 7.4e-09 36.2 0.0 1.7 2 1 0 2 2 2 1 MobA-like NTP transferase domain IspD PF01128.19 ACT02472.1 - 0.033 13.9 0.0 0.047 13.4 0.0 1.2 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GDP_Man_Dehyd PF16363.5 ACT02473.1 - 3.5e-38 131.8 0.0 1.1e-37 130.2 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ACT02473.1 - 2.1e-33 115.8 0.0 2.6e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ACT02473.1 - 1.3e-10 40.9 0.0 8.4e-10 38.3 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ACT02473.1 - 1.7e-09 37.2 0.0 2.3e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ACT02473.1 - 5e-05 22.4 0.0 6.4e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ACT02473.1 - 0.0012 18.1 0.0 0.0044 16.2 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein Methyltransf_14 PF08484.11 ACT02474.1 - 1.2e-60 203.9 0.0 1.7e-60 203.5 0.0 1.2 1 0 0 1 1 1 1 C-methyltransferase C-terminal domain Methyltransf_23 PF13489.6 ACT02474.1 - 2e-17 63.5 0.0 5.5e-17 62.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_13 PF08421.11 ACT02474.1 - 2.2e-16 59.8 0.3 4e-16 59.0 0.3 1.5 1 0 0 1 1 1 1 Putative zinc binding domain Methyltransf_12 PF08242.12 ACT02474.1 - 3.9e-07 30.7 0.0 1.1e-06 29.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT02474.1 - 1.5e-05 25.6 0.0 9.1e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT02474.1 - 0.00024 21.8 0.0 0.0017 19.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT02474.1 - 0.0012 18.6 0.0 0.0022 17.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain dTDP_sugar_isom PF00908.17 ACT02475.1 - 7.9e-61 204.6 0.0 8.9e-61 204.5 0.0 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase Pepdidase_M14_N PF18027.1 ACT02475.1 - 0.045 14.1 0.1 0.069 13.5 0.1 1.5 1 1 0 1 1 1 0 Cytosolic carboxypeptidase N-terminal domain Hexapep PF00132.24 ACT02476.1 - 2e-14 52.7 13.8 9.8e-09 34.6 4.5 3.8 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACT02476.1 - 8.1e-11 41.5 15.5 1.5e-08 34.2 3.8 3.6 2 1 1 3 3 3 3 Hexapeptide repeat of succinyl-transferase Epimerase PF01370.21 ACT02477.1 - 4e-19 69.0 0.2 1.2e-13 51.1 0.0 2.1 1 1 1 2 2 2 2 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACT02477.1 - 1.5e-05 24.6 0.0 0.017 14.5 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ACT02477.1 - 0.00057 19.1 0.1 0.023 13.8 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 ACT02477.1 - 0.005 16.0 0.0 0.32 10.1 0.0 2.1 2 0 0 2 2 2 2 RmlD substrate binding domain SLH PF00395.20 ACT02478.1 - 4.1e-11 42.7 4.7 0.00019 21.4 0.1 3.8 3 1 0 3 3 3 3 S-layer homology domain PrcB_C PF14343.6 ACT02478.1 - 0.00011 22.2 0.3 0.00053 20.1 0.1 2.1 1 1 1 2 2 2 1 PrcB C-terminal UDG PF03167.19 ACT02479.1 - 8.6e-27 94.0 0.0 1.2e-26 93.6 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Cauli_VI PF01693.16 ACT02480.1 - 7.3e-20 71.0 4.7 1.8e-19 69.8 4.2 1.9 2 0 0 2 2 2 1 Caulimovirus viroplasmin RNase_H PF00075.24 ACT02480.1 - 6.1e-05 23.2 0.0 0.0001 22.5 0.0 1.4 1 0 0 1 1 1 1 RNase H Glyco_hydro_98C PF08307.11 ACT02481.1 - 0.04 13.4 0.1 0.043 13.3 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 C-terminal domain 2_5_RNA_ligase2 PF13563.6 ACT02482.1 - 3.4e-22 79.0 0.3 4.1e-22 78.7 0.3 1.0 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 ACT02482.1 - 8e-08 32.4 1.5 5.3e-07 29.8 0.1 2.4 2 2 0 2 2 2 1 LigT like Phosphoesterase SBP_bac_1 PF01547.25 ACT02483.1 - 4.2e-19 69.7 12.6 6.6e-19 69.0 12.6 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein LIN52 PF10044.9 ACT02483.1 - 0.035 14.8 0.8 0.68 10.7 0.0 2.6 2 0 0 2 2 2 0 Retinal tissue protein ABC_tran PF00005.27 ACT02484.1 - 1.1e-30 107.0 0.0 1.7e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02484.1 - 1.7e-08 34.7 0.5 0.0042 16.9 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT02484.1 - 0.00028 20.6 0.2 0.00062 19.5 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT02484.1 - 0.00041 20.3 0.2 0.00091 19.2 0.2 1.5 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 ACT02484.1 - 0.00045 19.7 0.6 0.26 10.7 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACT02484.1 - 0.009 16.4 0.0 0.015 15.7 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 ACT02484.1 - 0.013 15.6 0.5 0.047 13.8 0.1 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_22 PF13401.6 ACT02484.1 - 0.024 14.9 0.0 0.089 13.1 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ACT02484.1 - 0.03 14.8 0.0 0.057 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ACT02484.1 - 0.12 12.1 0.2 1.3 8.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain FeoB_N PF02421.18 ACT02484.1 - 0.12 11.9 0.1 0.51 9.8 0.0 2.0 2 0 0 2 2 2 0 Ferrous iron transport protein B SbcCD_C PF13558.6 ACT02484.1 - 0.14 12.4 0.1 2 8.7 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 ACT02484.1 - 0.16 11.6 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain IIGP PF05049.13 ACT02484.1 - 0.19 10.7 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) FtsX PF02687.21 ACT02485.1 - 7.9e-13 48.7 13.7 1.1e-08 35.4 5.7 4.9 6 1 1 7 7 7 2 FtsX-like permease family MacB_PCD PF12704.7 ACT02485.1 - 2e-12 47.9 0.2 3.8e-06 27.4 0.1 2.6 2 0 0 2 2 2 2 MacB-like periplasmic core domain GRP PF07172.11 ACT02485.1 - 0.028 15.1 22.4 0.063 14.0 22.4 1.5 1 0 0 1 1 1 0 Glycine rich protein family Biotin_lipoyl_2 PF13533.6 ACT02486.1 - 5.1e-13 48.6 1.1 7.2e-06 25.7 0.1 3.1 3 0 0 3 3 3 2 Biotin-lipoyl like HlyD_D23 PF16576.5 ACT02486.1 - 2.1e-10 40.2 1.5 3.7e-10 39.4 1.5 1.4 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 ACT02486.1 - 2.4e-10 41.0 8.1 3.5e-10 40.5 0.6 3.5 3 1 1 4 4 4 1 HlyD family secretion protein Biotin_lipoyl PF00364.22 ACT02486.1 - 3.3e-06 26.8 0.4 0.0056 16.5 0.0 2.9 2 0 0 2 2 2 2 Biotin-requiring enzyme Peptidase_M23 PF01551.22 ACT02486.1 - 0.00023 21.3 0.0 0.0098 16.1 0.0 2.7 2 0 0 2 2 2 1 Peptidase family M23 RnfC_N PF13375.6 ACT02486.1 - 0.013 15.5 0.2 5.3 7.1 0.1 2.7 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain PYNP_C PF07831.13 ACT02486.1 - 0.079 12.6 0.2 10 5.8 0.0 2.6 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain ABC_tran PF00005.27 ACT02487.1 - 1.5e-31 109.7 0.0 2e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02487.1 - 2.1e-06 27.8 0.3 0.016 15.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT02487.1 - 8.4e-05 22.1 0.0 0.002 17.6 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT02487.1 - 0.00038 20.2 0.0 0.00072 19.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ACT02487.1 - 0.00061 19.6 0.2 0.083 12.6 0.1 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_16 PF13191.6 ACT02487.1 - 0.0014 19.0 0.0 0.0025 18.2 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ACT02487.1 - 0.0019 18.2 0.0 0.0031 17.4 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 ACT02487.1 - 0.014 15.9 0.0 0.026 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ACT02487.1 - 0.039 13.9 0.2 0.079 12.9 0.2 1.5 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 ACT02487.1 - 0.047 13.3 0.2 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 ACT02487.1 - 0.066 13.1 0.0 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_22 PF13401.6 ACT02487.1 - 0.11 12.8 0.4 0.27 11.5 0.4 1.8 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ACT02487.1 - 0.11 11.7 0.2 0.41 9.8 0.1 1.8 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.6 ACT02487.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ACT02487.1 - 0.12 12.5 0.5 0.32 11.2 0.3 1.8 2 0 0 2 2 2 0 AAA domain DLIC PF05783.11 ACT02487.1 - 0.15 10.9 0.0 0.22 10.3 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) DAP3 PF10236.9 ACT02487.1 - 0.16 11.1 0.2 11 5.1 0.2 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 SbcCD_C PF13558.6 ACT02487.1 - 0.19 12.0 0.1 3.8 7.8 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit PduV-EutP PF10662.9 ACT02487.1 - 0.3 10.8 1.1 0.44 10.3 0.1 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MCPsignal PF00015.21 ACT02488.1 - 5.9e-37 127.1 19.5 5.9e-37 127.1 19.5 4.7 2 1 3 5 5 5 3 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 ACT02488.1 - 0.0048 16.9 22.1 0.11 12.6 0.3 5.7 4 2 2 6 6 6 3 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 ACT02488.1 - 0.0069 16.7 17.4 1.1 9.6 2.6 5.4 3 2 2 5 5 5 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 ACT02488.1 - 0.0099 16.1 10.6 0.77 9.9 0.8 3.9 2 1 0 3 3 3 2 Fibrinogen alpha/beta chain family Sec34 PF04136.15 ACT02488.1 - 0.015 15.2 7.4 2.6 7.9 0.0 3.8 3 0 0 3 3 3 0 Sec34-like family DUF948 PF06103.11 ACT02488.1 - 0.045 14.0 28.4 5.8 7.2 6.5 6.5 3 2 4 7 7 7 0 Bacterial protein of unknown function (DUF948) DASH_Duo1 PF08651.10 ACT02488.1 - 0.046 13.5 8.8 17 5.3 0.2 5.4 4 0 0 4 4 4 0 DASH complex subunit Duo1 Med9 PF07544.13 ACT02488.1 - 0.08 13.0 2.2 2.4 8.3 0.0 4.2 4 1 1 5 5 5 0 RNA polymerase II transcription mediator complex subunit 9 LOH1CR12 PF10158.9 ACT02488.1 - 0.083 12.9 5.4 7.7 6.5 0.0 3.9 2 2 1 3 3 3 0 Tumour suppressor protein Hep_59 PF07052.11 ACT02488.1 - 0.22 12.3 4.7 0.26 12.1 0.4 2.9 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 Snapin_Pallidin PF14712.6 ACT02488.1 - 0.34 11.3 8.5 5.3 7.5 0.2 4.4 4 1 1 5 5 5 0 Snapin/Pallidin NPV_P10 PF05531.12 ACT02488.1 - 1.4 9.5 10.8 3.4 8.2 0.5 4.3 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein UPF0242 PF06785.11 ACT02488.1 - 1.5 8.9 12.8 0.64 10.1 0.6 3.4 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 ACT02488.1 - 8.1 5.2 19.7 0.1 11.5 0.7 3.4 2 1 0 3 3 3 0 Spc7 kinetochore protein Pribosyltran PF00156.27 ACT02489.1 - 8.4e-15 54.6 0.0 1.1e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain OMPdecase PF00215.24 ACT02490.1 - 4.1e-42 144.3 0.2 4.6e-42 144.1 0.2 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family CPSase_L_D2 PF02786.17 ACT02491.1 - 3.5e-121 402.4 0.5 2.8e-83 278.6 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 ACT02491.1 - 3.3e-45 153.4 0.1 7.4e-45 152.2 0.1 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain MGS PF02142.22 ACT02491.1 - 1.5e-20 73.1 1.9 3.2e-19 68.9 0.0 4.1 5 0 0 5 5 5 1 MGS-like domain Dala_Dala_lig_C PF07478.13 ACT02491.1 - 1.8e-19 70.1 0.6 3.6e-09 36.5 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ACT02491.1 - 1.7e-17 63.5 0.3 2.8e-08 33.5 0.1 2.3 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_3 PF02655.14 ACT02491.1 - 8.5e-16 58.4 2.0 3.5e-10 40.2 0.2 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 ACT02491.1 - 9.5e-15 54.5 0.0 5.9e-07 29.3 0.0 2.7 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.19 ACT02491.1 - 1.6e-11 44.3 0.4 7.9e-07 29.0 0.2 2.7 2 1 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.6 ACT02491.1 - 1.5e-06 27.8 0.1 0.026 14.0 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_4 PF13535.6 ACT02491.1 - 5.3e-06 26.1 0.6 0.0042 16.7 0.1 3.2 3 1 0 3 3 3 2 ATP-grasp domain ATP-grasp_2 PF08442.10 ACT02491.1 - 0.0016 18.0 0.0 1.5 8.4 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain CoA_binding_2 PF13380.6 ACT02491.1 - 0.0071 16.8 0.0 0.13 12.7 0.0 3.2 4 0 0 4 4 3 1 CoA binding domain PrpR_N PF06506.11 ACT02491.1 - 0.016 14.8 1.1 9.7 5.7 0.1 4.5 4 1 1 5 5 5 0 Propionate catabolism activator MucBP_2 PF17965.1 ACT02491.1 - 0.026 15.1 0.1 12 6.5 0.0 3.3 3 0 0 3 3 3 0 Mucin binding domain PA PF02225.22 ACT02491.1 - 0.072 13.1 0.0 0.26 11.3 0.0 1.9 2 0 0 2 2 2 0 PA domain CPSase_sm_chain PF00988.22 ACT02492.1 - 1.1e-53 180.5 0.0 1.7e-53 179.8 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 ACT02492.1 - 2.1e-48 164.6 0.0 3.5e-48 163.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ACT02492.1 - 5.5e-08 32.8 0.3 0.0048 16.7 0.1 2.4 1 1 1 2 2 2 2 Peptidase C26 Amidohydro_1 PF01979.20 ACT02493.1 - 5.4e-48 164.1 0.1 7.5e-48 163.6 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase family DHOase PF12890.7 ACT02493.1 - 4.7e-28 97.9 0.0 8.7e-28 97.0 0.0 1.4 1 0 0 1 1 1 1 Dihydro-orotase-like Amidohydro_3 PF07969.11 ACT02493.1 - 8.9e-19 68.3 1.9 2.1e-10 40.7 0.0 2.7 3 1 0 3 3 3 2 Amidohydrolase family TatD_DNase PF01026.21 ACT02493.1 - 0.0005 19.5 0.0 0.0025 17.3 0.0 2.0 1 1 0 2 2 2 1 TatD related DNase OTCace_N PF02729.21 ACT02494.1 - 9.9e-45 152.2 0.0 2e-44 151.2 0.0 1.5 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 ACT02494.1 - 6e-22 78.4 0.9 2.7e-20 73.0 0.2 2.6 2 1 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 2-Hacid_dh_C PF02826.19 ACT02494.1 - 0.0012 18.2 0.0 0.0029 17.0 0.0 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pribosyltran PF00156.27 ACT02495.1 - 3.5e-21 75.4 0.6 4.7e-21 75.0 0.6 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ACT02495.1 - 0.0015 18.0 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 ACT02495.1 - 0.006 16.1 0.0 0.01 15.3 0.0 1.7 1 1 0 1 1 1 1 Phosphoribosyl transferase Aminotran_1_2 PF00155.21 ACT02496.1 - 6.7e-69 232.8 0.0 7.6e-69 232.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ACT02496.1 - 1.6e-09 37.5 0.0 2.6e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ACT02496.1 - 8.8e-05 21.6 0.0 0.00015 20.9 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ACT02496.1 - 0.00021 19.9 0.0 0.00034 19.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 ACT02496.1 - 0.00068 19.0 0.0 0.0019 17.5 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase OKR_DC_1 PF01276.20 ACT02496.1 - 0.014 14.1 0.0 0.02 13.6 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Peptidase_M20 PF01546.28 ACT02497.1 - 1.1e-25 90.6 0.2 1.3e-25 90.4 0.2 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ACT02497.1 - 3.2e-10 39.9 0.0 5.9e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain DapH_N PF08503.10 ACT02498.1 - 1.2e-30 105.6 0.1 1.2e-30 105.6 0.1 1.6 2 0 0 2 2 2 1 Tetrahydrodipicolinate succinyltransferase N-terminal Hexapep PF00132.24 ACT02498.1 - 3.7e-22 77.2 21.6 6.4e-08 32.0 5.0 3.5 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACT02498.1 - 1.9e-13 49.9 20.8 3.2e-08 33.2 6.0 3.9 3 1 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase UCH_C PF18031.1 ACT02498.1 - 0.046 13.6 1.8 0.084 12.8 1.8 1.4 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolases Urocanase_C PF17392.2 ACT02498.1 - 0.14 11.6 3.0 0.56 9.6 0.8 2.6 2 1 2 4 4 4 0 Urocanase C-terminal domain PseudoU_synth_2 PF00849.22 ACT02499.1 - 2.6e-35 121.9 0.1 3.4e-35 121.5 0.1 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 ACT02499.1 - 1.4e-09 37.5 0.0 2.8e-09 36.5 0.0 1.6 1 1 0 1 1 1 1 S4 domain GSH-S_N PF02951.14 ACT02499.1 - 0.14 12.3 0.1 3.4 7.8 0.0 2.3 2 0 0 2 2 2 0 Prokaryotic glutathione synthetase, N-terminal domain Peptidase_A8 PF01252.18 ACT02500.1 - 1.5e-36 125.8 11.0 1.7e-36 125.6 11.0 1.0 1 0 0 1 1 1 1 Signal peptidase (SPase) II DUF3169 PF11368.8 ACT02500.1 - 9.1e-05 22.1 5.5 0.00051 19.6 0.0 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF3169) MerC PF03203.14 ACT02500.1 - 0.2 12.1 3.6 0.18 12.3 1.9 1.7 1 1 1 2 2 2 0 MerC mercury resistance protein Glucos_trans_II PF14264.6 ACT02500.1 - 0.75 9.1 11.0 0.34 10.2 8.4 1.6 1 1 1 2 2 2 0 Glucosyl transferase GtrII PTPS_related PF10131.9 ACT02500.1 - 0.93 7.7 5.8 0.94 7.7 5.8 1.1 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein zf-dskA_traR PF01258.17 ACT02501.1 - 1.9e-09 37.3 1.0 3e-09 36.7 1.0 1.3 1 0 0 1 1 1 1 Prokaryotic dksA/traR C4-type zinc finger CAMSAP_CC1 PF17095.5 ACT02501.1 - 0.046 13.6 2.2 0.081 12.8 2.2 1.4 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin RE_AccI PF09545.10 ACT02502.1 - 0.0092 15.0 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 AccI restriction endonuclease DUF378 PF04070.12 ACT02502.1 - 0.011 15.6 0.5 0.019 14.8 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF378) tRNA-synt_1 PF00133.22 ACT02503.1 - 3.4e-196 653.1 0.2 5e-195 649.3 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ACT02503.1 - 5.9e-32 110.7 0.0 3.1e-31 108.4 0.0 2.1 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ACT02503.1 - 8.8e-22 77.4 0.7 1.7e-09 36.9 0.0 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ACT02503.1 - 7e-06 25.6 0.0 0.0029 17.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 ACT02503.1 - 3.8e-05 22.8 0.0 0.00043 19.3 0.0 2.4 3 0 0 3 3 3 1 tRNA synthetases class I (K) tRNA-synt_1_2 PF13603.6 ACT02503.1 - 0.0029 17.1 0.0 0.007 15.9 0.0 1.6 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 DivIVA PF05103.13 ACT02504.1 - 2.1e-49 167.0 9.2 2.5e-49 166.7 9.2 1.1 1 0 0 1 1 1 1 DivIVA protein PV-1 PF06637.11 ACT02504.1 - 0.0085 15.0 6.4 0.01 14.7 6.4 1.1 1 0 0 1 1 1 1 PV-1 protein (PLVAP) HALZ PF02183.18 ACT02504.1 - 0.011 16.0 0.3 0.011 16.0 0.3 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper V-ATPase_G_2 PF16999.5 ACT02504.1 - 0.022 15.2 4.6 0.042 14.3 4.6 1.6 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit DUF2087 PF09860.9 ACT02504.1 - 0.034 14.3 0.1 0.079 13.1 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) Sec34 PF04136.15 ACT02504.1 - 0.047 13.6 5.7 2.1 8.2 5.5 2.5 1 1 0 1 1 1 0 Sec34-like family 4HB_MCP_1 PF12729.7 ACT02504.1 - 0.072 12.6 7.8 0.1 12.1 7.8 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction DUF484 PF04340.12 ACT02504.1 - 0.17 11.6 4.1 0.33 10.6 3.7 1.6 1 1 1 2 2 2 0 Protein of unknown function, DUF484 DUF4446 PF14584.6 ACT02504.1 - 0.24 11.4 7.5 3.9 7.4 0.2 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF4446) DUF1664 PF07889.12 ACT02504.1 - 0.3 11.1 5.3 0.35 10.9 2.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FAM184 PF15665.5 ACT02504.1 - 0.34 10.7 12.3 0.3 10.8 7.4 2.0 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B CorA PF01544.18 ACT02504.1 - 2.5 7.3 8.6 3.1 7.0 8.6 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Peptidase_M41 PF01434.18 ACT02504.1 - 2.6 7.9 6.9 4.8 7.0 3.1 2.1 1 1 1 2 2 2 0 Peptidase family M41 TMPIT PF07851.13 ACT02504.1 - 3.9 6.6 6.9 5 6.3 6.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein YabA PF06156.13 ACT02504.1 - 9.2 7.0 8.1 7.6 7.2 4.8 2.1 1 1 1 2 2 2 0 Initiation control protein YabA YlmH_RBD PF17774.1 ACT02505.1 - 3.9e-13 49.5 0.1 8.9e-13 48.4 0.1 1.6 1 0 0 1 1 1 1 Putative RNA-binding domain in YlmH S4 PF01479.25 ACT02505.1 - 0.00012 21.7 0.1 0.00023 20.8 0.1 1.5 1 0 0 1 1 1 1 S4 domain DbpA PF03880.15 ACT02505.1 - 0.0027 17.6 0.0 0.0071 16.3 0.0 1.7 1 0 0 1 1 1 1 DbpA RNA binding domain MLVIN_C PF18697.1 ACT02505.1 - 0.14 12.3 0.0 0.48 10.6 0.0 1.8 2 0 0 2 2 2 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain HTH_11 PF08279.12 ACT02505.1 - 0.16 11.9 0.2 23 5.0 0.0 2.4 2 0 0 2 2 2 0 HTH domain YGGT PF02325.17 ACT02506.1 - 1.8e-19 69.9 6.5 1.9e-19 69.8 5.8 1.4 1 1 0 1 1 1 1 YGGT family SepF PF04472.12 ACT02507.1 - 1.5e-28 98.9 0.0 2.2e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 Cell division protein SepF DUF4441 PF14536.6 ACT02507.1 - 0.038 14.2 0.0 0.058 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4441) Ala_racemase_N PF01168.20 ACT02508.1 - 2e-20 73.4 0.2 2.6e-20 73.0 0.2 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Bac_luciferase PF00296.20 ACT02508.1 - 0.068 12.6 0.3 0.11 11.9 0.3 1.3 1 0 0 1 1 1 0 Luciferase-like monooxygenase Orn_Arg_deC_N PF02784.16 ACT02508.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Herpes_ori_bp PF02399.15 ACT02508.1 - 0.19 9.8 0.0 0.22 9.5 0.0 1.1 1 0 0 1 1 1 0 Origin of replication binding protein PSK_trans_fac PF07704.11 ACT02508.1 - 2 9.2 7.0 2 9.2 3.3 2.4 2 1 0 2 2 2 0 Rv0623-like transcription factor Cu-oxidase_4 PF02578.15 ACT02509.1 - 5.7e-78 261.7 0.0 6.6e-78 261.5 0.0 1.0 1 0 0 1 1 1 1 Multi-copper polyphenol oxidoreductase laccase PRC PF05239.16 ACT02510.1 - 1.9e-13 50.3 2.4 2.4e-13 50.0 2.4 1.1 1 0 0 1 1 1 1 PRC-barrel domain Sigma70_r2 PF04542.14 ACT02511.1 - 8.8e-18 63.9 0.0 1.8e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 ACT02511.1 - 1.6e-16 59.5 0.2 6.1e-15 54.5 0.1 2.4 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r3 PF04539.16 ACT02511.1 - 3.5e-09 36.6 0.0 1.6e-06 28.1 0.0 2.6 2 0 0 2 2 2 1 Sigma-70 region 3 Sigma70_r4_2 PF08281.12 ACT02511.1 - 1.3e-07 31.2 0.3 3.7e-07 29.7 0.1 1.8 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_3 PF01381.22 ACT02511.1 - 3.8e-05 23.7 0.2 0.0022 18.0 0.3 2.4 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 ACT02511.1 - 0.00024 21.4 0.1 0.0018 18.6 0.0 2.3 2 1 0 2 2 2 1 Helix-turn-helix domain KORA PF16509.5 ACT02511.1 - 0.00073 19.8 2.0 0.0013 19.0 0.5 2.0 2 0 0 2 2 2 1 TrfB plasmid transcriptional repressor Trp_repressor PF01371.19 ACT02511.1 - 0.0024 18.0 0.7 0.055 13.6 0.1 2.5 2 0 0 2 2 2 1 Trp repressor protein HTH_23 PF13384.6 ACT02511.1 - 0.0025 17.5 0.0 0.014 15.1 0.0 2.2 3 0 0 3 3 2 1 Homeodomain-like domain Sigma70_ECF PF07638.11 ACT02511.1 - 0.0049 16.8 0.1 0.0083 16.0 0.1 1.4 1 0 0 1 1 1 1 ECF sigma factor GerE PF00196.19 ACT02511.1 - 0.0055 16.2 0.5 0.015 14.8 0.3 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family HTH_28 PF13518.6 ACT02511.1 - 0.019 15.1 0.0 0.21 11.7 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain WYL_3 PF18488.1 ACT02511.1 - 0.028 14.8 0.5 0.92 9.9 0.0 2.5 2 0 0 2 2 2 0 WYL domain DUF1492 PF07374.11 ACT02511.1 - 0.036 14.2 0.2 0.081 13.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) HTH_37 PF13744.6 ACT02511.1 - 0.046 13.7 0.2 0.14 12.1 0.2 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_19 PF12844.7 ACT02511.1 - 0.099 12.7 0.3 0.35 10.9 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r2 PF04542.14 ACT02512.1 - 3.5e-19 68.3 0.3 7.1e-19 67.3 0.0 1.7 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 ACT02512.1 - 4.4e-16 58.1 1.7 4.4e-16 58.1 1.7 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_3 PF01381.22 ACT02512.1 - 4.6e-06 26.6 0.1 1.4e-05 25.1 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix Sigma70_r4_2 PF08281.12 ACT02512.1 - 4.8e-05 23.0 1.5 0.00022 20.8 0.8 2.5 2 1 0 2 2 2 1 Sigma-70, region 4 HTH_31 PF13560.6 ACT02512.1 - 0.00012 22.3 0.0 0.00023 21.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 ACT02512.1 - 0.00039 20.1 0.1 0.0013 18.5 0.1 1.9 2 0 0 2 2 1 1 Homeodomain-like domain HTH_19 PF12844.7 ACT02512.1 - 0.0013 18.7 0.6 0.013 15.5 0.6 2.7 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 ACT02512.1 - 0.002 18.1 0.2 0.0039 17.1 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 ACT02512.1 - 0.0035 17.2 0.1 0.019 14.8 0.0 2.2 2 1 1 3 3 2 1 MarR family KORA PF16509.5 ACT02512.1 - 0.0065 16.7 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 TrfB plasmid transcriptional repressor TBPIP PF07106.13 ACT02512.1 - 0.022 14.7 0.1 0.11 12.5 0.0 2.1 2 0 0 2 2 2 0 TBPIP/Hop2 winged helix domain HTH_5 PF01022.20 ACT02512.1 - 0.031 14.1 0.0 1.2 9.0 0.0 2.6 2 1 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_25 PF13413.6 ACT02512.1 - 0.035 14.0 0.0 0.097 12.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_17 PF12728.7 ACT02512.1 - 0.037 14.2 0.0 0.2 11.9 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Trp_repressor PF01371.19 ACT02512.1 - 0.045 13.9 0.2 0.087 13.0 0.2 1.5 1 0 0 1 1 1 0 Trp repressor protein HTH_28 PF13518.6 ACT02512.1 - 0.064 13.4 0.1 0.23 11.6 0.0 2.1 2 0 0 2 2 1 0 Helix-turn-helix domain GerE PF00196.19 ACT02512.1 - 0.083 12.5 0.1 0.18 11.4 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family Phage_CII PF05269.11 ACT02512.1 - 0.097 12.9 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Bacteriophage CII protein Phage_CI_repr PF07022.13 ACT02512.1 - 0.098 12.8 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain HTH_Tnp_4 PF13613.6 ACT02512.1 - 0.9 9.3 2.9 2.9 7.7 0.0 2.7 3 0 0 3 3 2 0 Helix-turn-helix of DDE superfamily endonuclease Peptidase_U4 PF03419.13 ACT02513.1 - 1.5e-82 277.1 1.1 1.7e-82 276.9 1.1 1.0 1 0 0 1 1 1 1 Sporulation factor SpoIIGA EDS1_EP PF18117.1 ACT02514.1 - 0.035 14.6 0.0 0.039 14.4 0.0 1.2 1 0 0 1 1 1 0 Enhanced disease susceptibility 1 protein EP domain Tubulin PF00091.25 ACT02515.1 - 1.7e-43 149.1 0.5 2.9e-43 148.4 0.5 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.8 ACT02515.1 - 1.2e-34 118.5 3.2 3.3e-34 117.1 3.2 1.8 1 0 0 1 1 1 1 FtsZ family, C-terminal domain ATP-synt_D PF01813.17 ACT02515.1 - 0.069 13.0 0.0 0.18 11.6 0.0 1.7 2 0 0 2 2 2 0 ATP synthase subunit D Tubulin_2 PF13809.6 ACT02515.1 - 6.7 5.8 8.8 4.3 6.4 2.8 2.4 1 1 1 2 2 2 0 Tubulin like FtsA PF14450.6 ACT02516.1 - 4.9e-33 113.6 5.0 2.5e-20 72.8 0.1 2.1 2 0 0 2 2 2 2 Cell division protein FtsA SHS2_FTSA PF02491.20 ACT02516.1 - 1.1e-28 99.4 0.5 3e-28 98.0 0.5 1.8 1 0 0 1 1 1 1 SHS2 domain inserted in FTSA MreB_Mbl PF06723.13 ACT02516.1 - 2.2e-09 36.6 8.3 4.1e-09 35.7 2.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein PilM_2 PF11104.8 ACT02516.1 - 2.9e-05 23.3 3.6 0.031 13.3 0.0 3.2 3 0 0 3 3 3 2 Type IV pilus assembly protein PilM; FGGY_N PF00370.21 ACT02516.1 - 0.027 14.0 0.8 0.046 13.3 0.8 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Ubiquitin_3 PF14836.6 ACT02516.1 - 0.17 11.9 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain POTRA_1 PF08478.10 ACT02517.1 - 8.4e-15 54.8 0.0 2.1e-14 53.5 0.0 1.7 2 0 0 2 2 2 1 POTRA domain, FtsQ-type YqfD PF06898.11 ACT02517.1 - 0.069 12.0 0.2 0.1 11.4 0.2 1.2 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD FtsQ PF03799.15 ACT02517.1 - 0.097 13.5 0.0 0.28 12.0 0.0 1.7 1 1 1 2 2 2 0 Cell division protein FtsQ EPSP_synthase PF00275.20 ACT02518.1 - 2.1e-94 316.6 3.4 2.4e-94 316.4 3.4 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) MurB_C PF02873.16 ACT02519.1 - 2.9e-29 101.6 0.0 5.5e-29 100.7 0.0 1.5 1 0 0 1 1 1 1 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain FAD_binding_4 PF01565.23 ACT02519.1 - 1e-20 73.9 0.3 2e-20 73.0 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain FTSW_RODA_SPOVE PF01098.19 ACT02520.1 - 2e-117 392.2 32.8 2.4e-117 392.0 32.8 1.0 1 0 0 1 1 1 1 Cell cycle protein Mur_ligase_M PF08245.12 ACT02521.1 - 2.7e-33 115.6 0.0 4.4e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 ACT02521.1 - 2.5e-07 30.9 0.0 1.7e-06 28.2 0.0 2.5 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain 2-Hacid_dh_C PF02826.19 ACT02521.1 - 0.004 16.5 0.0 0.0083 15.5 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ACT02521.1 - 0.038 14.5 0.2 0.26 11.9 0.1 2.4 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Glycos_transf_4 PF00953.21 ACT02522.1 - 1.7e-39 135.3 14.5 1.7e-39 135.3 14.5 2.2 3 0 0 3 3 3 1 Glycosyl transferase family 4 MraY_sig1 PF10555.9 ACT02522.1 - 9.3e-05 21.8 4.6 9.3e-05 21.8 4.6 2.3 2 0 0 2 2 2 1 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 Mur_ligase_M PF08245.12 ACT02523.1 - 4e-49 167.2 0.1 6.9e-49 166.5 0.1 1.4 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 ACT02523.1 - 2.8e-15 56.3 0.0 1.9e-14 53.7 0.0 2.2 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain Mur_ligase PF01225.25 ACT02523.1 - 2.3e-12 47.0 0.0 1.9e-11 44.1 0.0 2.3 2 0 0 2 2 2 1 Mur ligase family, catalytic domain AAA_30 PF13604.6 ACT02523.1 - 0.071 12.8 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain Mur_ligase_M PF08245.12 ACT02524.1 - 5.5e-60 202.7 0.9 7.6e-60 202.2 0.9 1.2 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 ACT02524.1 - 1.9e-26 92.2 0.0 1.6e-24 86.0 0.0 2.7 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain Mur_ligase PF01225.25 ACT02524.1 - 6.9e-15 55.1 0.0 2e-14 53.7 0.0 1.9 1 0 0 1 1 1 1 Mur ligase family, catalytic domain RraA-like PF03737.15 ACT02524.1 - 0.02 15.1 0.2 5.1 7.3 0.0 3.3 2 1 0 3 3 3 0 Aldolase/RraA LpxD PF04613.14 ACT02524.1 - 0.032 14.0 1.5 0.055 13.3 0.2 2.1 2 0 0 2 2 2 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD Transpeptidase PF00905.22 ACT02525.1 - 6.4e-85 285.0 0.0 9.1e-85 284.5 0.0 1.2 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 ACT02525.1 - 2.1e-19 70.5 0.1 1.4e-17 64.6 0.1 2.8 2 1 0 2 2 2 1 Penicillin-binding Protein dimerisation domain PASTA PF03793.19 ACT02525.1 - 9.1e-08 31.8 0.1 2.8e-07 30.3 0.1 2.0 1 0 0 1 1 1 1 PASTA domain DUF2158 PF09926.9 ACT02525.1 - 0.11 12.3 0.1 0.33 10.7 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized small protein (DUF2158) Transpeptidase PF00905.22 ACT02526.1 - 3.5e-81 272.8 6.2 6.6e-81 271.9 6.2 1.5 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 ACT02526.1 - 7.3e-16 59.0 9.4 3.3e-15 56.9 5.0 3.2 2 1 0 2 2 2 1 Penicillin-binding Protein dimerisation domain PASTA PF03793.19 ACT02526.1 - 9.5e-13 47.8 4.2 1.1e-07 31.5 1.1 3.0 2 0 0 2 2 2 2 PASTA domain Beta-lactamase2 PF13354.6 ACT02526.1 - 0.0067 16.0 0.0 0.04 13.5 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase enzyme family DivIC PF04977.15 ACT02527.1 - 3e-08 33.3 0.2 4.4e-08 32.8 0.2 1.2 1 0 0 1 1 1 1 Septum formation initiator Peptidase_S49_N PF08496.10 ACT02527.1 - 0.021 14.9 1.3 0.029 14.5 1.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FtsL PF04999.13 ACT02527.1 - 0.022 14.8 0.5 0.029 14.3 0.5 1.2 1 0 0 1 1 1 0 Cell division protein FtsL TMEM132D_C PF15706.5 ACT02527.1 - 0.023 14.5 0.7 0.034 13.9 0.6 1.4 1 1 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term HCMV_UL139 PF12507.8 ACT02527.1 - 0.032 14.6 0.1 0.043 14.2 0.1 1.2 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein DUF5378 PF17349.2 ACT02527.1 - 0.085 12.2 2.1 0.11 11.8 2.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Methyltransf_5 PF01795.19 ACT02528.1 - 2.8e-125 417.9 0.0 3.1e-125 417.8 0.0 1.0 1 0 0 1 1 1 1 MraW methylase family rRNA_methylase PF06962.12 ACT02528.1 - 0.016 15.2 0.0 1.9 8.5 0.0 2.2 2 0 0 2 2 2 0 Putative rRNA methylase Ubie_methyltran PF01209.18 ACT02528.1 - 0.034 13.5 0.0 0.58 9.5 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ACT02528.1 - 0.06 14.1 0.0 1.2 9.8 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain MraZ PF02381.18 ACT02529.1 - 1.6e-49 165.8 0.0 1.4e-24 85.9 0.0 2.0 2 0 0 2 2 2 2 MraZ protein, putative antitoxin-like DUF2375 PF09558.10 ACT02529.1 - 0.016 15.2 0.0 0.52 10.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2375) MazE_antitoxin PF04014.18 ACT02529.1 - 0.098 12.6 0.0 0.41 10.6 0.0 1.9 2 0 0 2 2 2 0 Antidote-toxin recognition MazE, bacterial antitoxin DUF4349 PF14257.6 ACT02530.1 - 1.3e-66 224.1 1.3 2.7e-66 223.1 0.3 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4349) DUF452 PF04301.13 ACT02530.1 - 0.036 13.6 0.1 0.054 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF452) DUF713 PF05218.14 ACT02530.1 - 0.054 13.2 0.3 0.1 12.3 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF713) TSC22 PF01166.18 ACT02530.1 - 0.15 12.4 0.1 0.39 11.1 0.1 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family Com_YlbF PF06133.11 ACT02530.1 - 0.16 12.6 2.8 0.31 11.7 2.8 1.4 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA DUF3040 PF11239.8 ACT02530.1 - 4.1 7.7 5.3 2.8 8.3 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Arginase PF00491.21 ACT02531.1 - 1.5e-68 231.3 0.1 1.8e-68 231.1 0.1 1.0 1 0 0 1 1 1 1 Arginase family Aminotran_3 PF00202.21 ACT02532.1 - 2.4e-127 425.0 0.0 2.8e-127 424.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ACT02532.1 - 0.00024 20.4 0.0 0.00081 18.7 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ACT02532.1 - 0.0014 18.0 0.5 0.017 14.5 0.2 2.6 2 1 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ACT02532.1 - 0.0074 15.3 0.0 0.044 12.7 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V AdoHcyase PF05221.17 ACT02533.1 - 1.1e-53 182.3 0.0 3.7e-27 95.3 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 ACT02533.1 - 2.2e-52 177.4 1.1 2.2e-52 177.4 1.1 1.8 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 ACT02533.1 - 6.6e-09 35.5 0.5 1.4e-08 34.5 0.2 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 ACT02533.1 - 2.2e-08 33.6 0.1 4.8e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ACT02533.1 - 0.023 14.0 1.1 0.048 13.0 1.1 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain BshC PF10079.9 ACT02534.1 - 2.4e-165 551.4 0.0 2.7e-165 551.2 0.0 1.0 1 0 0 1 1 1 1 Bacillithiol biosynthesis BshC Propep_M14 PF02244.16 ACT02534.1 - 0.059 13.8 0.0 0.2 12.0 0.0 1.9 1 0 0 1 1 1 0 Carboxypeptidase activation peptide DUF515 PF04415.12 ACT02534.1 - 0.06 11.7 0.1 0.099 11.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) FANC_SAP PF18081.1 ACT02534.1 - 0.073 13.2 2.9 0.48 10.6 0.3 3.2 3 0 0 3 3 3 0 Fanconi anemia-associated nuclease SAP domain T2SSF PF00482.23 ACT02534.1 - 0.076 13.0 0.1 1.7 8.6 0.0 2.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF3397 PF11877.8 ACT02535.1 - 6.1e-30 103.7 9.2 7.1e-30 103.5 9.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3397) DUF3981 PF13139.6 ACT02535.1 - 0.02 15.3 1.8 0.035 14.5 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3981) DUF2157 PF09925.9 ACT02535.1 - 0.79 9.5 7.3 0.085 12.6 1.9 1.9 1 1 0 2 2 2 0 Predicted membrane protein (DUF2157) PEP-CTERM PF07589.11 ACT02535.1 - 8 6.7 7.1 1.6 8.9 2.3 2.4 2 0 0 2 2 2 0 PEP-CTERM motif ApbA_C PF08546.11 ACT02536.1 - 1.6e-33 115.5 0.0 2.5e-33 115.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ACT02536.1 - 8.4e-17 61.2 0.0 1.2e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Phage_GP20 PF06810.11 ACT02537.1 - 6.7e-06 26.0 1.5 1.1e-05 25.2 1.5 1.4 1 0 0 1 1 1 1 Phage minor structural protein GP20 ADIP PF11559.8 ACT02537.1 - 9.6e-05 22.5 1.2 9.6e-05 22.5 1.2 2.0 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 ACT02537.1 - 0.00014 22.1 3.9 0.00014 22.1 3.9 1.7 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Myb_DNA-bind_6 PF13921.6 ACT02537.1 - 0.00016 21.8 1.0 0.0004 20.6 0.1 2.1 2 1 0 2 2 2 1 Myb-like DNA-binding domain TMF_DNA_bd PF12329.8 ACT02537.1 - 0.00017 21.5 3.0 0.00036 20.5 1.2 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 ACT02537.1 - 0.0003 20.5 2.5 0.0003 20.5 2.5 2.2 2 0 0 2 2 2 1 Septum formation initiator DUF745 PF05335.13 ACT02537.1 - 0.003 17.3 1.7 0.0042 16.8 0.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF745) Myb_DNA-binding PF00249.31 ACT02537.1 - 0.0033 17.6 0.0 0.018 15.2 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Tropomyosin_1 PF12718.7 ACT02537.1 - 0.0034 17.6 3.2 0.0034 17.6 3.2 1.8 2 0 0 2 2 2 1 Tropomyosin like KLRAQ PF10205.9 ACT02537.1 - 0.0039 17.4 2.4 0.0039 17.4 2.4 1.7 2 0 0 2 2 1 1 Predicted coiled-coil domain-containing protein DUF4763 PF15960.5 ACT02537.1 - 0.0042 16.4 2.9 0.0064 15.8 0.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4763) FlaC_arch PF05377.11 ACT02537.1 - 0.005 17.2 1.4 0.01 16.2 1.4 1.6 1 0 0 1 1 1 1 Flagella accessory protein C (FlaC) CorA PF01544.18 ACT02537.1 - 0.0056 16.0 2.1 0.0087 15.4 2.1 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein CC2-LZ PF16516.5 ACT02537.1 - 0.0078 16.6 1.1 0.0078 16.6 1.1 2.0 2 0 0 2 2 2 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Dor1 PF04124.12 ACT02537.1 - 0.0079 14.9 1.3 0.014 14.1 1.3 1.4 1 0 0 1 1 1 1 Dor1-like family Med21 PF11221.8 ACT02537.1 - 0.0093 16.2 2.4 0.015 15.5 2.4 1.3 1 0 0 1 1 1 1 Subunit 21 of Mediator complex AAA_23 PF13476.6 ACT02537.1 - 0.011 16.3 1.8 0.013 16.0 1.8 1.2 1 0 0 1 1 1 0 AAA domain TSNAXIP1_N PF15739.5 ACT02537.1 - 0.011 16.1 3.0 1.6 9.2 0.0 2.4 2 1 0 2 2 2 0 Translin-associated factor X-interacting N-terminus DUF1664 PF07889.12 ACT02537.1 - 0.011 15.8 1.0 0.023 14.7 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FH2 PF02181.23 ACT02537.1 - 0.011 14.8 0.7 0.017 14.3 0.7 1.2 1 0 0 1 1 1 0 Formin Homology 2 Domain YabA PF06156.13 ACT02537.1 - 0.02 15.5 2.0 0.024 15.3 0.8 1.8 2 0 0 2 2 1 0 Initiation control protein YabA OmpH PF03938.14 ACT02537.1 - 0.027 14.8 1.3 0.027 14.8 1.3 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) FAM76 PF16046.5 ACT02537.1 - 0.03 13.7 3.4 0.038 13.4 3.4 1.1 1 0 0 1 1 1 0 FAM76 protein DUF4446 PF14584.6 ACT02537.1 - 0.056 13.4 1.9 0.084 12.9 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF641 PF04859.12 ACT02537.1 - 0.064 13.6 3.4 0.14 12.5 3.2 1.7 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF948 PF06103.11 ACT02537.1 - 0.078 13.3 0.2 0.18 12.1 0.2 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) APG6_N PF17675.1 ACT02537.1 - 0.079 13.5 7.1 0.17 12.4 7.1 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region GAS PF13851.6 ACT02537.1 - 0.095 12.0 7.4 0.036 13.4 2.6 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Spore_III_AB PF09548.10 ACT02537.1 - 0.14 12.3 2.8 3.8 7.6 0.3 2.2 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) TMF_TATA_bd PF12325.8 ACT02537.1 - 0.2 11.9 6.5 0.036 14.3 2.4 1.9 2 0 0 2 2 1 0 TATA element modulatory factor 1 TATA binding V_ATPase_I PF01496.19 ACT02537.1 - 0.24 9.3 4.3 0.27 9.1 4.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0242 PF06785.11 ACT02537.1 - 0.24 11.5 7.0 0.42 10.7 6.6 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIVA PF05103.13 ACT02537.1 - 0.3 11.2 7.9 0.057 13.5 2.9 2.2 1 1 0 1 1 1 0 DivIVA protein Fez1 PF06818.15 ACT02537.1 - 0.32 11.4 8.8 1 9.8 8.9 1.8 1 1 1 2 2 2 0 Fez1 SlyX PF04102.12 ACT02537.1 - 0.32 11.6 3.2 0.42 11.3 0.6 2.3 2 0 0 2 2 2 0 SlyX Fungal_TACC PF12709.7 ACT02537.1 - 0.51 10.8 7.2 0.085 13.3 2.1 2.2 2 1 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF724 PF05266.14 ACT02537.1 - 0.62 9.9 5.9 0.16 11.8 1.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF4200 PF13863.6 ACT02537.1 - 0.87 10.0 12.0 0.4 11.1 6.5 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) TolA_bind_tri PF16331.5 ACT02537.1 - 2.8 8.1 10.3 0.18 11.9 3.7 2.4 2 1 0 2 2 2 0 TolA binding protein trimerisation DUF2205 PF10224.9 ACT02537.1 - 2.9 8.0 6.6 0.53 10.3 0.9 2.2 2 0 0 2 2 2 0 Short coiled-coil protein DUF2626 PF11117.8 ACT02538.1 - 1.3e-34 118.8 18.9 1.4e-34 118.6 18.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2626) Popeye PF04831.13 ACT02538.1 - 1.2 9.3 6.3 0.52 10.5 4.3 1.4 1 1 0 1 1 1 0 Popeye protein conserved region Methyltransf_28 PF02636.17 ACT02539.1 - 4.9e-37 128.0 0.0 6.7e-37 127.5 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.12 ACT02539.1 - 0.067 13.9 0.0 0.47 11.2 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain PSA_CBD PF18341.1 ACT02539.1 - 0.082 12.9 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 PSA endolysin C-terminal cell wall binding domain Methyltransf_31 PF13847.6 ACT02539.1 - 0.16 11.8 0.0 0.47 10.2 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain TetR_C_21 PF17926.1 ACT02540.1 - 0.0049 17.0 0.2 0.012 15.7 0.2 1.6 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain DUF2730 PF10805.8 ACT02540.1 - 0.0064 16.6 0.3 0.0064 16.6 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2730) DUF2993 PF11209.8 ACT02540.1 - 0.0067 16.7 0.0 0.01 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2993) HemX PF04375.14 ACT02540.1 - 0.015 14.6 3.0 1.5 8.1 1.2 2.2 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase COG2 PF06148.11 ACT02540.1 - 0.028 14.5 6.7 0.29 11.2 0.5 2.8 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Phage_GPO PF05929.11 ACT02540.1 - 0.15 11.6 3.6 0.41 10.2 0.1 2.2 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase WXG100 PF06013.12 ACT02540.1 - 0.16 12.2 3.1 4 7.7 0.6 2.7 1 1 1 2 2 2 0 Proteins of 100 residues with WXG KASH PF10541.9 ACT02540.1 - 0.17 12.2 0.2 0.3 11.4 0.2 1.4 1 0 0 1 1 1 0 Nuclear envelope localisation domain Baculo_PEP_C PF04513.12 ACT02540.1 - 0.27 11.3 1.6 0.31 11.1 0.1 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.13 ACT02540.1 - 0.38 10.0 6.9 1.3 8.2 0.9 3.0 3 0 0 3 3 3 0 TMPIT-like protein Exonuc_VII_L PF02601.15 ACT02540.1 - 0.53 9.8 4.6 0.66 9.5 4.2 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF16 PF01519.16 ACT02540.1 - 1.6 9.2 10.6 0.21 12.1 2.4 3.0 2 1 0 2 2 2 0 Protein of unknown function DUF16 Atg14 PF10186.9 ACT02540.1 - 2.3 7.2 8.2 3.7 6.5 1.2 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 SBP_bac_1 PF01547.25 ACT02541.1 - 6.1e-14 52.7 0.8 1.9e-12 47.8 0.1 2.3 3 0 0 3 3 3 2 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT02541.1 - 5.9e-13 49.3 0.5 7.7e-10 39.1 0.1 2.2 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein PhoH PF02562.16 ACT02542.1 - 1e-53 181.9 0.0 2.1e-53 180.9 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein PIN_4 PF13638.6 ACT02542.1 - 4.8e-33 114.2 0.1 7.8e-33 113.5 0.1 1.4 1 0 0 1 1 1 1 PIN domain AAA_30 PF13604.6 ACT02542.1 - 3.2e-12 46.6 0.0 1.3e-10 41.3 0.0 3.0 3 1 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ACT02542.1 - 4.1e-06 27.1 0.3 4.5e-05 23.7 0.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ACT02542.1 - 7.2e-06 26.4 0.1 0.0042 17.4 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.6 ACT02542.1 - 0.00092 19.1 0.1 0.38 10.5 0.0 2.2 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 ACT02542.1 - 0.0016 18.2 0.0 0.0037 17.0 0.0 1.6 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 ACT02542.1 - 0.01 15.1 0.1 0.23 10.7 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 ACT02542.1 - 0.025 14.1 0.0 0.069 12.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region DEAD PF00270.29 ACT02542.1 - 0.039 13.7 0.0 2.4 7.9 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase IstB_IS21 PF01695.17 ACT02542.1 - 0.043 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein UvrD-helicase PF00580.21 ACT02542.1 - 0.052 13.1 0.2 0.4 10.1 0.0 2.0 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_25 PF13481.6 ACT02542.1 - 0.12 12.0 0.1 0.26 10.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ACT02542.1 - 1.2 9.5 3.0 13 6.2 3.0 2.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Spore_YhcN_YlaJ PF09580.10 ACT02543.1 - 8.9e-16 58.4 0.1 1.2e-15 58.0 0.1 1.1 1 0 0 1 1 1 1 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HTH_49 PF18010.1 ACT02544.1 - 0.062 13.2 0.6 0.13 12.2 0.1 1.8 2 0 0 2 2 2 0 Cry35Ab1 HTH C-terminal domain LytR_cpsA_psr PF03816.14 ACT02545.1 - 3.2e-34 118.3 2.1 4.9e-34 117.7 2.1 1.3 1 0 0 1 1 1 1 Cell envelope-related transcriptional attenuator domain DUF4307 PF14155.6 ACT02545.1 - 0.027 14.3 0.3 0.048 13.5 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) DUF2140 PF09911.9 ACT02545.1 - 0.042 13.4 0.5 0.077 12.5 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF3357 PF11837.8 ACT02545.1 - 0.13 12.7 0.1 0.24 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) SNARE PF05739.19 ACT02545.1 - 0.32 11.0 2.4 0.85 9.7 2.2 1.9 2 0 0 2 2 2 0 SNARE domain ClpS PF02617.17 ACT02546.1 - 0.11 12.3 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 ATP-dependent Clp protease adaptor protein ClpS YlaH PF14036.6 ACT02547.1 - 5.5e-28 97.1 5.4 6.4e-28 96.9 5.4 1.0 1 0 0 1 1 1 1 YlaH-like protein GPI2 PF06432.11 ACT02547.1 - 0.031 13.7 0.9 0.036 13.5 0.9 1.0 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase TssN PF17555.2 ACT02547.1 - 0.29 10.5 5.9 0.083 12.3 3.3 1.3 2 0 0 2 2 2 0 Type VI secretion system, TssN GTP_EFTU PF00009.27 ACT02548.1 - 1.7e-58 197.3 0.2 2.7e-58 196.7 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ACT02548.1 - 3.7e-22 78.2 0.0 8.3e-22 77.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ACT02548.1 - 1.7e-12 47.5 4.1 5.1e-12 46.0 4.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ACT02548.1 - 9.1e-07 29.0 0.1 2e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 ACT02548.1 - 4.5e-06 26.7 0.0 1.2e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Arf PF00025.21 ACT02548.1 - 0.0021 17.6 0.0 0.011 15.3 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family Septin PF00735.18 ACT02548.1 - 0.0071 15.7 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Septin FeoB_N PF02421.18 ACT02548.1 - 0.0092 15.5 0.3 0.11 12.0 0.2 2.7 2 1 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.10 ACT02548.1 - 0.012 15.0 0.2 0.1 12.1 0.2 2.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 ACT02548.1 - 0.034 14.2 0.0 0.9 9.6 0.0 2.3 1 1 1 2 2 2 0 Dynamin family Roc PF08477.13 ACT02548.1 - 0.082 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ACT02548.1 - 0.14 11.7 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 Ras family NACHT PF05729.12 ACT02548.1 - 0.15 11.9 0.1 4.7 7.1 0.0 2.7 2 1 0 3 3 3 0 NACHT domain TerC PF03741.16 ACT02550.1 - 2.9e-44 150.9 4.0 3.7e-44 150.6 4.0 1.1 1 0 0 1 1 1 1 Integral membrane protein TerC family TerC PF03741.16 ACT02551.1 - 1.1e-45 155.5 10.7 1.1e-45 155.5 10.7 1.6 2 0 0 2 2 2 1 Integral membrane protein TerC family TMEM191C PF15194.6 ACT02551.1 - 4.5 7.5 6.2 0.69 10.1 1.2 2.1 2 1 0 3 3 3 0 TMEM191C family ThiI PF02568.14 ACT02552.1 - 6.5e-63 211.9 0.0 9.7e-63 211.3 0.0 1.2 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) THUMP PF02926.17 ACT02552.1 - 1.8e-15 57.3 0.0 3.6e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 THUMP domain QueC PF06508.13 ACT02552.1 - 3.7e-07 29.9 0.0 9.2e-06 25.3 0.0 2.4 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC NAD_synthase PF02540.17 ACT02552.1 - 0.14 11.3 0.1 0.5 9.4 0.0 1.9 1 1 1 2 2 2 0 NAD synthase Aminotran_5 PF00266.19 ACT02553.1 - 4.1e-74 249.8 0.0 4.7e-74 249.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ACT02553.1 - 0.0051 16.1 0.0 0.0085 15.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ACT02553.1 - 0.14 11.4 0.0 0.32 10.3 0.0 1.5 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family SLT PF01464.20 ACT02554.1 - 9.3e-30 102.7 0.0 3.7e-29 100.8 0.0 1.8 2 0 0 2 2 2 1 Transglycosylase SLT domain SLT_2 PF13406.6 ACT02554.1 - 0.00082 18.7 0.1 0.073 12.3 0.0 2.1 1 1 1 2 2 2 2 Transglycosylase SLT domain DUF1402 PF07182.11 ACT02554.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1402) Nitroreductase PF00881.24 ACT02555.1 - 1.1e-16 61.3 0.0 1.3e-16 61.1 0.0 1.0 1 0 0 1 1 1 1 Nitroreductase family Laminin_G_3 PF13385.6 ACT02556.1 - 0.0072 16.5 0.1 0.013 15.6 0.1 1.6 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Glyco_hydro_16 PF00722.21 ACT02556.1 - 0.0096 15.4 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF2259 PF10016.9 ACT02556.1 - 0.049 13.6 0.0 4.9 7.0 0.0 2.1 2 0 0 2 2 2 0 Predicted secreted protein (DUF2259) TTD PF12148.8 ACT02556.1 - 0.073 12.9 0.2 0.44 10.4 0.2 1.9 1 1 0 1 1 1 0 Tandem tudor domain within UHRF1 UbiA PF01040.18 ACT02557.1 - 9.3e-29 100.5 22.9 1.2e-28 100.1 22.9 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF2070 PF09843.9 ACT02557.1 - 9.5 4.4 8.1 34 2.5 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) DUF2157 PF09925.9 ACT02558.1 - 0.26 11.1 7.3 2 8.2 7.6 2.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) DUF1600 PF07667.11 ACT02558.1 - 2.6 8.3 16.0 0.11 12.7 1.4 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1600) ABC_tran PF00005.27 ACT02559.1 - 2.3e-23 83.2 0.0 3.7e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02559.1 - 1.6e-10 41.3 0.5 5.4e-05 23.1 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT02559.1 - 0.00033 20.3 0.1 0.00066 19.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 ACT02559.1 - 0.0034 16.9 0.4 0.61 9.5 0.1 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 ACT02559.1 - 0.079 12.7 0.0 0.11 12.2 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ACT02559.1 - 0.091 13.3 0.1 0.24 11.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ACT02559.1 - 0.13 11.7 0.3 0.25 10.7 0.1 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI GntR PF00392.21 ACT02560.1 - 2.3e-12 46.4 0.1 3.8e-12 45.7 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family MarR_2 PF12802.7 ACT02560.1 - 1.1e-07 31.6 0.1 1.6e-05 24.7 0.1 2.3 2 0 0 2 2 2 1 MarR family Rrf2 PF02082.20 ACT02560.1 - 3.2e-06 27.4 0.0 4.9e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator HTH_Crp_2 PF13545.6 ACT02560.1 - 8.5e-05 22.5 0.2 0.00018 21.4 0.2 1.5 1 1 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_41 PF14502.6 ACT02560.1 - 0.00078 19.1 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Fe_dep_repress PF01325.19 ACT02560.1 - 0.001 19.2 0.0 0.0019 18.3 0.0 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_24 PF13412.6 ACT02560.1 - 0.0015 18.1 0.0 0.0033 17.0 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_36 PF13730.6 ACT02560.1 - 0.0018 18.2 0.0 0.0053 16.7 0.0 1.9 2 1 0 2 2 2 1 Helix-turn-helix domain TrmB PF01978.19 ACT02560.1 - 0.005 16.7 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_DeoR PF08220.12 ACT02560.1 - 0.014 15.1 0.1 0.023 14.4 0.1 1.4 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_20 PF12840.7 ACT02560.1 - 0.021 14.9 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain LexA_DNA_bind PF01726.16 ACT02560.1 - 0.025 14.3 0.0 0.053 13.3 0.0 1.6 1 0 0 1 1 1 0 LexA DNA binding domain HTH_11 PF08279.12 ACT02560.1 - 0.027 14.4 0.1 0.056 13.4 0.1 1.6 1 0 0 1 1 1 0 HTH domain mTERF PF02536.14 ACT02560.1 - 0.028 13.4 0.1 0.039 12.9 0.1 1.3 1 1 0 1 1 1 0 mTERF HTH_IclR PF09339.10 ACT02560.1 - 0.038 13.8 0.0 0.085 12.7 0.0 1.6 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_5 PF01022.20 ACT02560.1 - 0.078 12.9 0.0 0.2 11.5 0.0 1.7 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_23 PF13384.6 ACT02560.1 - 0.097 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain HTH_29 PF13551.6 ACT02560.1 - 0.12 12.4 0.0 0.5 10.4 0.0 2.0 2 1 0 2 2 2 0 Winged helix-turn helix Ribosomal_S19e PF01090.19 ACT02560.1 - 0.13 11.9 0.1 0.21 11.3 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein S19e RPA_C PF08784.11 ACT02560.1 - 0.15 12.8 0.2 0.99 10.1 0.1 2.1 2 1 0 2 2 2 0 Replication protein A C terminal ABC2_membrane_2 PF12679.7 ACT02561.1 - 3.6e-19 69.1 28.1 6.3e-19 68.3 28.1 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 ACT02561.1 - 7e-18 65.2 12.3 7e-18 65.2 12.3 2.1 1 1 0 2 2 2 1 ABC-2 family transporter protein DUF2705 PF10920.8 ACT02561.1 - 7.3e-09 35.3 15.9 1e-08 34.8 15.7 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2705) ABC2_membrane_5 PF13346.6 ACT02561.1 - 4.7e-05 23.0 31.8 0.00065 19.3 31.8 2.2 1 1 0 1 1 1 1 ABC-2 family transporter protein PDGLE PF13190.6 ACT02561.1 - 0.034 14.0 3.6 0.54 10.2 3.6 2.7 1 1 0 1 1 1 0 PDGLE domain DUF5596 PF18082.1 ACT02561.1 - 0.19 11.6 0.5 1.5 8.7 0.0 2.6 4 0 0 4 4 4 0 Domain of unknown function (DUF5596) ABC2_membrane_3 PF12698.7 ACT02561.1 - 1.3 8.1 38.2 0.13 11.4 29.0 2.7 1 1 1 2 2 2 0 ABC-2 family transporter protein ABC_tran PF00005.27 ACT02562.1 - 5.7e-29 101.4 0.0 1.1e-28 100.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02562.1 - 2.1e-11 44.2 0.3 1.6e-06 28.2 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 ACT02562.1 - 0.00019 21.2 0.3 0.00072 19.3 0.3 1.8 1 1 0 1 1 1 1 AAA domain DUF4162 PF13732.6 ACT02562.1 - 0.00053 20.6 0.1 0.0011 19.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_23 PF13476.6 ACT02562.1 - 0.011 16.2 0.2 0.018 15.6 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ACT02562.1 - 0.012 15.9 0.6 3.4 8.0 0.3 2.4 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 ACT02562.1 - 0.072 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 ACT02562.1 - 0.074 12.5 0.1 4.1 6.8 0.1 2.6 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain TsaE PF02367.17 ACT02562.1 - 0.074 13.0 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 ACT02562.1 - 0.087 13.3 0.5 0.23 11.9 0.1 2.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 ACT02562.1 - 0.11 12.2 0.0 7.5 6.1 0.0 2.1 1 1 1 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 ACT02562.1 - 0.13 12.0 0.1 0.28 10.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain HRXXH PF13933.6 ACT02563.1 - 0.049 13.2 0.0 0.071 12.7 0.0 1.1 1 0 0 1 1 1 0 Putative peptidase family MCPsignal PF00015.21 ACT02564.1 - 6e-31 107.6 33.9 4.3e-30 104.8 12.7 3.6 2 1 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF948 PF06103.11 ACT02564.1 - 0.00079 19.6 32.7 0.059 13.6 1.2 6.8 4 1 3 8 8 8 2 Bacterial protein of unknown function (DUF948) IFT57 PF10498.9 ACT02564.1 - 0.0038 16.2 3.8 0.0038 16.2 3.8 3.8 3 2 1 4 4 4 2 Intra-flagellar transport protein 57 T7SS_ESX_EspC PF10824.8 ACT02564.1 - 0.0079 16.6 0.3 0.0079 16.6 0.3 4.3 3 1 0 4 4 4 1 Excreted virulence factor EspC, type VII ESX diderm HAMP PF00672.25 ACT02564.1 - 0.01 16.2 0.3 0.15 12.5 0.0 3.1 4 0 0 4 4 4 0 HAMP domain Med30 PF11315.8 ACT02564.1 - 0.022 14.9 11.0 0.081 13.1 0.2 4.1 3 1 2 5 5 5 0 Mediator complex subunit 30 Laminin_II PF06009.12 ACT02564.1 - 0.033 14.2 27.7 0.33 11.0 2.3 5.4 2 1 4 6 6 6 0 Laminin Domain II DUF1664 PF07889.12 ACT02564.1 - 0.27 11.3 27.4 0.19 11.8 2.9 5.4 3 2 3 6 6 6 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 ACT02564.1 - 0.3 11.2 16.9 0.088 12.9 0.4 4.4 2 2 2 4 4 4 0 TPR/MLP1/MLP2-like protein BLOC1_2 PF10046.9 ACT02564.1 - 0.54 10.6 30.1 1.7 9.0 0.8 5.9 4 2 2 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1451 PF07295.11 ACT02564.1 - 3.5 7.7 8.5 0.24 11.4 0.9 2.9 3 1 0 3 3 3 0 Zinc-ribbon containing domain DUF745 PF05335.13 ACT02564.1 - 4.7 6.9 24.8 0.18 11.5 5.6 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF745) IZUMO PF15005.6 ACT02564.1 - 7.3 7.1 10.2 1.1 9.8 0.2 3.8 3 3 1 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated DUF2536 PF10750.9 ACT02565.1 - 1e-35 121.4 4.0 1.1e-35 121.3 4.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2536) MtrG PF04210.13 ACT02565.1 - 0.11 12.4 0.6 0.54 10.2 0.1 2.0 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Aminotran_3 PF00202.21 ACT02566.1 - 7.9e-109 364.0 0.0 9.2e-109 363.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 ACT02566.1 - 6.3e-05 22.4 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase HIT PF01230.23 ACT02567.1 - 2.4e-15 57.0 0.0 3.5e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ACT02567.1 - 5.9e-08 33.2 0.3 1.1e-07 32.3 0.3 1.5 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ACT02567.1 - 0.008 16.0 0.4 0.011 15.5 0.4 1.4 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 NUDIX PF00293.28 ACT02568.1 - 2.2e-17 63.3 0.0 2.7e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain DUF1317 PF07026.11 ACT02568.1 - 0.03 14.1 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1317) DUF4916 PF16262.5 ACT02568.1 - 0.07 12.6 0.0 0.43 10.1 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4916) Methyltransf_25 PF13649.6 ACT02569.1 - 1.5e-15 57.7 0.0 3.1e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT02569.1 - 1.6e-12 47.9 0.0 2.5e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT02569.1 - 7e-10 39.5 0.0 1.1e-09 38.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT02569.1 - 1.5e-09 37.9 0.0 1.9e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT02569.1 - 1.6e-09 37.8 0.0 2.2e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 ACT02569.1 - 1.6e-09 37.4 0.0 2.4e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Met_10 PF02475.16 ACT02569.1 - 7.6e-08 32.3 0.1 1.1e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.10 ACT02569.1 - 3.3e-06 26.8 0.0 4.1e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.14 ACT02569.1 - 1.4e-05 24.7 0.0 2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 ACT02569.1 - 2.6e-05 24.1 0.0 3.5e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GidB PF02527.15 ACT02569.1 - 4.7e-05 22.8 0.0 7.1e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G PrmA PF06325.13 ACT02569.1 - 0.00011 21.7 0.2 0.00017 21.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 ACT02569.1 - 0.0021 17.4 0.0 0.0024 17.2 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 ACT02569.1 - 0.0022 17.7 0.1 0.0027 17.3 0.1 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) UPF0020 PF01170.18 ACT02569.1 - 0.0026 17.5 0.0 0.0038 16.9 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 ADH_zinc_N PF00107.26 ACT02569.1 - 0.009 16.0 0.1 0.018 15.1 0.1 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_16 PF10294.9 ACT02569.1 - 0.011 15.5 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase RrnaAD PF00398.20 ACT02569.1 - 0.062 12.4 0.0 0.078 12.0 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TRM PF02005.16 ACT02569.1 - 0.065 12.4 0.0 0.089 11.9 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase DUF938 PF06080.12 ACT02569.1 - 0.075 12.8 0.0 0.12 12.1 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_24 PF13578.6 ACT02569.1 - 0.077 14.0 0.0 0.12 13.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain FAD_binding_4 PF01565.23 ACT02570.1 - 1.2e-24 86.6 0.2 1.9e-24 86.0 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 ACT02570.1 - 5.6e-19 69.0 0.2 1.2e-18 67.9 0.1 1.5 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase FAD_binding_5 PF00941.21 ACT02570.1 - 0.15 11.8 0.1 0.29 10.8 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain in molybdopterin dehydrogenase Fusion_gly PF00523.18 ACT02570.1 - 0.4 8.9 0.7 0.86 7.8 0.5 1.6 1 1 1 2 2 2 0 Fusion glycoprotein F0 DegV PF02645.16 ACT02573.1 - 1.1e-90 303.8 0.7 1.2e-90 303.6 0.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein, DegV family COG1307 Dak1_2 PF13684.6 ACT02573.1 - 1.1e-08 34.5 0.1 1.3e-08 34.3 0.1 1.1 1 0 0 1 1 1 1 Dihydroxyacetone kinase family F5_F8_type_C PF00754.25 ACT02574.1 - 1.5e-15 57.4 2.2 1.5e-15 57.4 2.2 4.6 6 0 0 6 6 6 1 F5/8 type C domain CBM_6 PF03422.15 ACT02574.1 - 2.2e-14 53.8 53.1 1.2e-07 32.1 9.1 6.1 5 0 0 5 5 5 3 Carbohydrate binding module (family 6) Pectate_lyase_3 PF12708.7 ACT02574.1 - 6.1e-12 45.8 15.9 6.1e-12 45.8 15.9 4.7 2 2 3 5 5 5 1 Pectate lyase superfamily protein Beta_helix PF13229.6 ACT02574.1 - 2.5e-11 43.7 99.4 3.3e-08 33.5 24.1 6.5 4 2 4 8 8 8 4 Right handed beta helix region DUF5010_C PF18099.1 ACT02574.1 - 1.2e-08 35.1 17.2 0.00055 20.0 0.4 5.2 4 1 1 5 5 5 2 DUF5010 C-terminal domain CzcE PF16986.5 ACT02574.1 - 0.00079 19.7 0.1 0.57 10.5 0.0 3.4 3 0 0 3 3 3 1 Heavy-metal resistance protein CzcE DUF642 PF04862.12 ACT02574.1 - 3.2 7.5 13.6 0.81 9.5 0.6 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF642) TTC5_OB PF16669.5 ACT02575.1 - 0.022 14.4 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat protein 5 OB fold domain DUF350 PF03994.14 ACT02576.1 - 1.3e-21 76.4 10.7 1.4e-10 41.2 1.8 2.2 2 0 0 2 2 2 2 Domain of Unknown Function (DUF350) CrgA PF06781.12 ACT02576.1 - 1.3 9.2 11.9 2 8.6 1.2 2.2 1 1 1 2 2 2 0 Cell division protein CrgA IlvGEDA_leader PF08046.11 ACT02576.1 - 3.1 7.3 10.2 7.5 6.1 10.2 1.7 1 0 0 1 1 1 0 IlvGEDA operon leader peptide GSP_synth PF03738.14 ACT02578.1 - 4.2e-58 197.3 0.0 5.1e-58 197.0 0.0 1.0 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp SIMPL PF04402.14 ACT02581.1 - 7.2e-42 144.1 0.5 8.1e-42 143.9 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF541) RcpC PF16976.5 ACT02581.1 - 0.084 12.9 0.8 0.17 12.0 0.2 1.8 2 0 0 2 2 2 0 Flp pilus assembly protein RcpC/CpaB GntR PF00392.21 ACT02582.1 - 2.4e-14 52.7 0.0 3.8e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Rrf2 PF02082.20 ACT02582.1 - 0.033 14.5 0.0 0.057 13.8 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator HTH_20 PF12840.7 ACT02582.1 - 0.055 13.5 0.0 0.094 12.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2250 PF10007.9 ACT02582.1 - 0.1 12.7 0.0 0.26 11.4 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) RPA_C PF08784.11 ACT02582.1 - 0.13 13.0 0.0 0.23 12.1 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal ABC2_membrane_5 PF13346.6 ACT02583.1 - 4e-15 55.9 25.3 5.1e-15 55.6 25.3 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 ACT02584.1 - 1.9e-25 90.0 0.0 2.9e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02584.1 - 3.5e-13 50.0 5.1 8.4e-09 35.7 0.8 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ACT02584.1 - 4.9e-06 26.5 7.3 7.4e-06 25.9 7.3 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT02584.1 - 0.0025 18.1 0.2 0.0074 16.6 0.2 1.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ACT02584.1 - 0.0026 17.5 0.0 0.0041 16.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 ACT02584.1 - 0.0027 17.2 2.0 0.085 12.3 1.8 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ACT02584.1 - 0.0087 16.6 8.2 0.017 15.7 8.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT02584.1 - 0.03 14.1 0.1 0.071 12.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PhoH PF02562.16 ACT02584.1 - 0.035 13.6 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein DUF763 PF05559.11 ACT02584.1 - 0.088 12.0 0.0 0.097 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF763) SRP54 PF00448.22 ACT02584.1 - 0.089 12.4 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain SbcCD_C PF13558.6 ACT02584.1 - 0.099 12.9 0.0 0.39 11.0 0.0 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit BPD_transp_1 PF00528.22 ACT02585.1 - 7e-19 68.3 14.1 7e-19 68.3 14.1 1.9 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02586.1 - 4.8e-21 75.3 15.3 4.8e-21 75.3 15.3 2.1 2 0 0 2 2 2 2 Binding-protein-dependent transport system inner membrane component DUF4064 PF13273.6 ACT02586.1 - 0.006 16.8 2.5 0.006 16.8 2.5 3.2 2 2 0 2 2 2 1 Protein of unknown function (DUF4064) TM_PBP2_N PF16296.5 ACT02586.1 - 0.0094 16.1 1.1 0.027 14.6 1.1 1.8 1 0 0 1 1 1 1 N-terminal of TM subunit in PBP-dependent ABC transporters SBP_bac_1 PF01547.25 ACT02587.1 - 1.4e-39 136.9 17.2 2.1e-39 136.3 17.2 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT02587.1 - 3.7e-32 112.3 11.1 3.7e-32 112.3 11.1 1.4 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT02587.1 - 0.00012 21.6 1.2 0.016 14.6 0.3 2.3 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein DUF1835 PF08874.10 ACT02588.1 - 4.8e-34 117.1 0.0 1e-33 116.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1835) DUF3658 PF12395.8 ACT02588.1 - 8.2e-27 93.2 0.1 2.6e-26 91.6 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function DUF2798 PF11391.8 ACT02589.1 - 7.8e-05 22.6 18.6 0.0014 18.6 4.7 3.1 2 2 0 2 2 2 2 Protein of unknown function (DUF2798) HTH_18 PF12833.7 ACT02590.1 - 3.2e-22 78.6 0.1 6.6e-22 77.6 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02590.1 - 7.3e-13 48.3 0.4 3.5e-05 23.8 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02590.1 - 8.6e-11 41.9 0.2 1.9e-10 40.8 0.2 1.6 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02590.1 - 3.6e-07 29.8 0.1 7.4e-07 28.8 0.1 1.5 1 0 0 1 1 1 1 Cupin domain ARD PF03079.14 ACT02590.1 - 0.06 13.5 0.2 0.13 12.5 0.2 1.5 1 0 0 1 1 1 0 ARD/ARD' family Cupin_1 PF00190.22 ACT02590.1 - 0.14 11.8 0.0 0.33 10.6 0.0 1.6 2 0 0 2 2 2 0 Cupin Glyco_hydro_88 PF07470.13 ACT02591.1 - 2.8e-107 358.8 3.1 3.2e-107 358.6 3.1 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 ACT02591.1 - 0.0037 16.8 0.8 8.6 5.8 0.0 3.1 2 1 1 3 3 3 2 Glycosyl hydrolase family 76 IMP2_N PF18590.1 ACT02591.1 - 0.03 14.9 0.1 0.13 12.8 0.1 2.1 2 0 0 2 2 2 0 Immune Mapped Protein 2 (IMP2) N-terminal domain LANC_like PF05147.13 ACT02591.1 - 0.051 12.2 0.0 0.11 11.0 0.0 1.5 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein GlcNAc_2-epim PF07221.11 ACT02591.1 - 0.059 12.6 1.4 5.5 6.1 0.1 3.0 2 1 1 3 3 3 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) ABC_membrane PF00664.23 ACT02592.1 - 1e-51 176.3 18.1 1.3e-51 175.9 18.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT02592.1 - 2.8e-28 99.2 0.0 9e-28 97.5 0.0 1.9 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ACT02592.1 - 4.2e-07 29.6 1.4 3e-05 23.6 0.0 2.8 2 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACT02592.1 - 0.0011 19.4 0.1 0.0051 17.2 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 ACT02592.1 - 0.002 17.4 0.1 0.0071 15.6 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 ACT02592.1 - 0.0054 16.5 0.0 0.42 10.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ACT02592.1 - 0.0073 16.4 0.0 0.021 14.9 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase SbcCD_C PF13558.6 ACT02592.1 - 0.0075 16.5 0.2 0.35 11.1 0.2 2.7 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit DUF87 PF01935.17 ACT02592.1 - 0.0083 16.2 0.0 0.024 14.8 0.0 1.7 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_29 PF13555.6 ACT02592.1 - 0.043 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT02592.1 - 0.051 13.5 0.0 0.14 12.1 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase Ploopntkinase3 PF18751.1 ACT02592.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_23 PF13476.6 ACT02592.1 - 0.17 12.4 0.1 0.48 10.9 0.1 1.7 1 0 0 1 1 1 0 AAA domain DUF4271 PF14093.6 ACT02592.1 - 5.9 6.7 17.0 1.1 9.1 12.7 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4271) ABC_membrane PF00664.23 ACT02593.1 - 1.1e-37 130.2 5.6 1.5e-37 129.8 5.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT02593.1 - 6.4e-29 101.2 0.0 1.4e-28 100.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT02593.1 - 6.4e-08 32.3 0.0 1.7e-05 24.4 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 ACT02593.1 - 0.0037 16.4 0.1 0.0065 15.6 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.6 ACT02593.1 - 0.0051 17.0 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain MobB PF03205.14 ACT02593.1 - 0.0059 16.5 0.2 0.038 13.9 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 ACT02593.1 - 0.012 15.8 0.2 0.057 13.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ACT02593.1 - 0.014 15.9 0.2 0.042 14.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain DUF87 PF01935.17 ACT02593.1 - 0.016 15.3 1.1 0.028 14.5 0.2 1.7 2 0 0 2 2 2 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 ACT02593.1 - 0.016 15.3 0.1 0.041 14.0 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.22 ACT02593.1 - 0.017 14.3 0.1 0.036 13.3 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 ACT02593.1 - 0.018 14.3 0.0 0.044 13.1 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin cobW PF02492.19 ACT02593.1 - 0.028 14.0 0.2 0.077 12.6 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.20 ACT02593.1 - 0.038 13.1 0.0 0.059 12.5 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_7 PF12775.7 ACT02593.1 - 0.054 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 ACT02593.1 - 0.054 13.2 0.0 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_14 PF13173.6 ACT02593.1 - 0.063 13.3 0.0 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ACT02593.1 - 0.1 13.0 0.8 0.27 11.6 0.8 1.8 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 ACT02593.1 - 0.13 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Septin Roc PF08477.13 ACT02593.1 - 0.16 12.2 0.0 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 ACT02593.1 - 0.18 11.7 0.2 0.41 10.6 0.2 1.6 1 0 0 1 1 1 0 NACHT domain EamA PF00892.20 ACT02595.1 - 8.3e-14 51.9 36.1 9.5e-07 29.1 21.2 2.8 2 1 0 2 2 2 2 EamA-like transporter family DUF3767 PF12597.8 ACT02595.1 - 1.1 9.2 5.0 1.8 8.4 1.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3767) ABC_tran PF00005.27 ACT02596.1 - 4.3e-24 85.6 0.0 6.9e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02596.1 - 1.3e-09 38.4 0.9 8.5e-06 25.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 ACT02596.1 - 0.00015 22.4 0.0 0.00039 21.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_29 PF13555.6 ACT02596.1 - 0.0025 17.5 0.1 0.0053 16.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ACT02596.1 - 0.007 16.9 0.1 0.015 15.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT02596.1 - 0.0088 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_10 PF12846.7 ACT02596.1 - 0.026 13.4 0.0 0.057 12.3 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain Mg_chelatase PF01078.21 ACT02596.1 - 0.027 13.9 0.0 0.058 12.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 ACT02596.1 - 0.055 13.2 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 ACT02596.1 - 0.084 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_15 PF13175.6 ACT02596.1 - 0.11 12.1 0.0 0.78 9.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 ACT02596.1 - 0.12 12.4 0.0 0.36 10.9 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_7 PF12775.7 ACT02596.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SMC_N PF02463.19 ACT02596.1 - 0.14 11.5 0.0 5.4 6.4 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_27 PF13514.6 ACT02596.1 - 0.17 11.4 0.1 0.32 10.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain ABC2_membrane_6 PF06182.11 ACT02597.1 - 1.9e-17 63.8 15.0 1.9e-17 63.8 15.0 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein ssDBP PF17878.1 ACT02597.1 - 0.17 12.2 0.0 0.25 11.6 0.0 1.2 1 0 0 1 1 1 0 Single-stranded DNA-binding protein ABC2_membrane_3 PF12698.7 ACT02597.1 - 1.9 7.5 28.3 0.019 14.1 14.9 2.4 1 1 0 2 2 2 0 ABC-2 family transporter protein ABC2_membrane_6 PF06182.11 ACT02598.1 - 9.3e-28 97.6 19.6 1.2e-27 97.2 19.6 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein PRT_C PF08372.10 ACT02598.1 - 1.9 8.2 4.2 0.34 10.7 0.4 1.6 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal ABC2_membrane_2 PF12679.7 ACT02599.1 - 4.3e-24 85.3 7.1 6.5e-24 84.7 7.1 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 ACT02599.1 - 2.6e-17 63.4 17.1 4.6e-15 56.0 9.7 3.1 3 0 0 3 3 3 2 ABC-2 family transporter protein DUF2705 PF10920.8 ACT02599.1 - 0.0014 18.0 15.1 0.0024 17.3 15.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2705) CDC48_2 PF02933.17 ACT02599.1 - 0.068 13.0 0.1 5.6 6.8 0.1 2.3 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 ABC2_membrane_5 PF13346.6 ACT02599.1 - 0.079 12.5 31.4 0.28 10.7 26.7 3.1 2 1 0 2 2 2 0 ABC-2 family transporter protein ABC_tran PF00005.27 ACT02600.1 - 6.1e-29 101.3 0.0 1.2e-28 100.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02600.1 - 1.5e-13 51.3 2.5 1.8e-09 37.8 0.2 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ACT02600.1 - 0.0034 17.9 1.5 0.0039 17.7 0.6 1.6 2 0 0 2 2 2 1 AAA domain DUF4162 PF13732.6 ACT02600.1 - 0.0098 16.6 0.2 0.027 15.2 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_22 PF13401.6 ACT02600.1 - 0.027 14.8 0.2 0.35 11.1 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ACT02600.1 - 0.059 13.8 0.6 0.15 12.5 0.3 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 ACT02600.1 - 0.068 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 ACT02600.1 - 0.07 12.6 0.0 13 5.1 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ACT02600.1 - 0.078 12.9 0.1 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase Methyltransf_21 PF05050.12 ACT02600.1 - 0.11 12.5 0.1 0.47 10.5 0.0 1.9 2 1 1 3 3 3 0 Methyltransferase FkbM domain AAA_15 PF13175.6 ACT02600.1 - 0.13 11.9 0.1 4.5 6.9 0.1 2.2 1 1 1 2 2 2 0 AAA ATPase domain DUF3817 PF12823.7 ACT02601.1 - 5.5e-23 81.6 6.0 6.1e-23 81.4 6.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3817) DUF998 PF06197.13 ACT02601.1 - 0.0045 16.6 3.9 0.0059 16.2 3.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF998) G3P_acyltransf PF02660.15 ACT02601.1 - 0.021 14.9 5.8 0.024 14.7 5.8 1.0 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase EamA PF00892.20 ACT02602.1 - 7.3e-53 178.4 40.3 2e-29 102.5 18.9 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 ACT02602.1 - 1.7e-05 24.3 16.2 4e-05 23.1 2.4 2.4 2 1 0 2 2 2 2 Triose-phosphate Transporter family SLC35F PF06027.12 ACT02602.1 - 6.1e-05 22.7 7.1 6.1e-05 22.7 7.1 1.5 1 1 0 1 1 1 1 Solute carrier family 35 UAA PF08449.11 ACT02602.1 - 0.0094 15.2 4.0 0.0094 15.2 4.0 2.5 2 1 0 2 2 2 1 UAA transporter family RseC_MucC PF04246.12 ACT02602.1 - 0.013 15.4 0.0 0.013 15.4 0.0 3.7 2 1 4 6 6 6 0 Positive regulator of sigma(E), RseC/MucC CRT-like PF08627.10 ACT02602.1 - 0.036 13.0 15.1 0.35 9.8 3.1 2.2 1 1 1 2 2 2 0 CRT-like, chloroquine-resistance transporter-like EpsG PF14897.6 ACT02602.1 - 0.058 12.7 13.3 0.072 12.4 3.9 2.3 2 0 0 2 2 2 0 EpsG family AC_N PF16214.5 ACT02602.1 - 1.4 8.0 5.4 2 7.4 5.4 1.3 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region LysR_substrate PF03466.20 ACT02603.1 - 1.4e-33 116.0 0.0 1.8e-33 115.7 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT02603.1 - 1.2e-18 66.8 0.5 2.1e-18 66.0 0.5 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family ABC2_membrane_3 PF12698.7 ACT02603.1 - 0.012 14.8 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein MarR PF01047.22 ACT02603.1 - 0.079 12.9 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 MarR family NIL PF09383.10 ACT02603.1 - 0.12 12.2 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 NIL domain Cupin_2 PF07883.11 ACT02604.1 - 3e-17 62.1 0.1 4.1e-17 61.6 0.1 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACT02604.1 - 2.9e-08 33.7 0.1 3.7e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 ACT02604.1 - 2.4e-05 24.0 0.0 3.2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Cupin FdtA PF05523.11 ACT02604.1 - 4.7e-05 23.1 0.0 5.4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 WxcM-like, C-terminal Cupin_3 PF05899.12 ACT02604.1 - 0.00034 20.3 0.0 0.00048 19.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_7 PF12973.7 ACT02604.1 - 0.0014 18.5 0.0 0.0017 18.2 0.0 1.1 1 0 0 1 1 1 1 ChrR Cupin-like domain CENP-C_C PF11699.8 ACT02604.1 - 0.0073 16.5 0.0 0.0093 16.2 0.0 1.1 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_4 PF08007.12 ACT02604.1 - 0.071 12.6 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein AP_endonuc_2 PF01261.24 ACT02605.1 - 2.1e-21 76.3 0.0 3e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel AP_endonuc_2_N PF07582.12 ACT02605.1 - 0.00023 20.8 0.2 0.0048 16.6 0.0 2.6 2 1 0 2 2 2 1 AP endonuclease family 2 C terminus GFO_IDH_MocA PF01408.22 ACT02606.1 - 3.6e-22 79.4 0.1 7.4e-22 78.4 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding PF02629.19 ACT02606.1 - 0.0012 19.5 0.0 0.0031 18.1 0.0 1.8 1 0 0 1 1 1 1 CoA binding domain NAD_binding_3 PF03447.16 ACT02606.1 - 0.01 16.5 0.0 0.019 15.6 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.17 ACT02606.1 - 0.033 14.2 0.0 0.081 12.9 0.0 1.7 1 1 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain PHA_gran_rgn PF09650.10 ACT02606.1 - 0.13 12.6 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) HTH_3 PF01381.22 ACT02607.1 - 1.9e-15 56.7 0.0 2.7e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 ACT02607.1 - 5.6e-13 48.7 0.0 9.1e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Cupin_2 PF07883.11 ACT02607.1 - 1.3e-12 47.2 0.1 2e-12 46.6 0.1 1.3 1 0 0 1 1 1 1 Cupin domain HTH_31 PF13560.6 ACT02607.1 - 2.1e-10 40.8 0.0 3e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 ACT02607.1 - 1.8e-08 34.7 0.0 2.6e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain Cupin_3 PF05899.12 ACT02607.1 - 9.9e-06 25.2 0.1 1.6e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) AraC_binding PF02311.19 ACT02607.1 - 6e-05 23.0 0.0 9.3e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_37 PF13744.6 ACT02607.1 - 0.00082 19.3 0.1 0.0012 18.7 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 ACT02607.1 - 0.057 13.3 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain CENP-C_C PF11699.8 ACT02607.1 - 0.091 13.0 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 Mif2/CENP-C like MerR_1 PF13411.6 ACT02608.1 - 7.6e-16 58.0 0.1 1.3e-15 57.2 0.1 1.3 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT02608.1 - 4.5e-10 39.1 0.1 7.2e-10 38.5 0.1 1.3 1 0 0 1 1 1 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT02608.1 - 0.0025 18.3 0.0 0.0039 17.7 0.0 1.4 1 0 0 1 1 1 1 MerR, DNA binding Arch_fla_DE PF04659.13 ACT02608.1 - 0.045 13.6 0.3 3.3 7.7 0.2 2.2 1 1 0 2 2 2 0 Archaeal flagella protein DUF764 PF05561.11 ACT02608.1 - 0.066 13.0 0.3 0.075 12.8 0.3 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF764) DUF3853 PF12964.7 ACT02608.1 - 0.11 12.6 0.0 0.28 11.4 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3853) DUF1882 PF08966.11 ACT02608.1 - 0.6 10.4 3.7 61 4.0 0.2 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF1882) adh_short PF00106.25 ACT02609.1 - 5.6e-30 104.3 0.0 6.4e-29 100.8 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT02609.1 - 1.2e-14 54.4 0.0 8e-14 51.8 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT02609.1 - 1.3e-06 28.4 0.1 3.2e-06 27.2 0.1 1.7 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 ACT02609.1 - 5.2e-06 26.1 0.0 7e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.6 ACT02609.1 - 0.044 14.2 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding DinB_2 PF12867.7 ACT02610.1 - 1.2e-12 48.4 3.7 1.5e-12 48.1 3.7 1.1 1 0 0 1 1 1 1 DinB superfamily DinB PF05163.12 ACT02610.1 - 9.6e-11 41.9 0.6 1.5e-10 41.3 0.6 1.2 1 0 0 1 1 1 1 DinB family DUF664 PF04978.12 ACT02610.1 - 0.0013 19.1 1.1 0.014 15.9 1.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF664) Tugs PF17840.1 ACT02610.1 - 0.035 14.3 0.5 0.068 13.4 0.5 1.4 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain EAP30 PF04157.16 ACT02610.1 - 0.12 11.7 0.0 0.47 9.7 0.0 1.8 2 0 0 2 2 2 0 EAP30/Vps36 family Vir_act_alpha_C PF10400.9 ACT02610.1 - 0.73 10.6 4.3 2.4 8.9 2.1 2.2 1 1 1 2 2 2 0 Virulence activator alpha C-term ABM PF03992.16 ACT02611.1 - 6.1e-19 67.9 0.1 1.1e-18 67.0 0.0 1.4 1 1 1 2 2 2 1 Antibiotic biosynthesis monooxygenase DJ-1_PfpI PF01965.24 ACT02612.1 - 6.2e-17 61.9 0.0 9.5e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ACT02612.1 - 6.6e-10 39.0 0.0 2.7e-07 30.5 0.0 2.2 1 1 0 1 1 1 1 ThiJ/PfpI family-like GATase_3 PF07685.14 ACT02612.1 - 0.0057 16.3 0.0 0.0085 15.7 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Catalase_C PF18011.1 ACT02612.1 - 0.12 12.0 0.0 0.32 10.6 0.0 1.6 1 1 0 1 1 1 0 C-terminal domain found in long catalases Peripla_BP_4 PF13407.6 ACT02613.1 - 2.7e-66 223.8 9.8 3.1e-66 223.6 9.8 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACT02613.1 - 2.2e-25 89.7 1.5 2.5e-25 89.5 1.5 1.0 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 ACT02613.1 - 2.2e-16 60.6 0.1 3.9e-15 56.6 0.1 2.2 1 1 1 2 2 2 1 Periplasmic binding protein-like domain ABC_sub_bind PF04392.12 ACT02613.1 - 2.8e-09 36.7 7.2 2.3e-05 23.8 2.3 2.1 2 0 0 2 2 2 2 ABC transporter substrate binding protein Peripla_BP_6 PF13458.6 ACT02613.1 - 4.1e-08 33.3 2.0 1e-07 32.0 2.2 1.5 1 1 0 1 1 1 1 Periplasmic binding protein Bmp PF02608.14 ACT02613.1 - 6.1e-06 25.4 4.1 0.0011 18.0 1.7 2.1 2 0 0 2 2 2 2 ABC transporter substrate-binding protein PnrA-like PucR PF07905.11 ACT02613.1 - 0.00045 20.5 0.0 0.0013 19.0 0.0 1.8 1 1 0 1 1 1 1 Purine catabolism regulatory protein-like family ANF_receptor PF01094.28 ACT02613.1 - 0.0015 17.7 0.1 0.01 14.9 0.0 1.9 2 0 0 2 2 2 1 Receptor family ligand binding region NAD_binding_3 PF03447.16 ACT02613.1 - 0.006 17.2 0.7 0.017 15.8 0.4 2.0 1 1 1 2 2 2 1 Homoserine dehydrogenase, NAD binding domain OKR_DC_1_N PF03709.15 ACT02613.1 - 0.0069 16.7 0.2 0.05 13.9 0.0 2.3 2 1 0 2 2 2 1 Orn/Lys/Arg decarboxylase, N-terminal domain SBP_bac_3 PF00497.20 ACT02613.1 - 0.041 13.3 2.1 0.12 11.8 1.8 2.0 1 1 1 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 3HCDH_RFF PF18321.1 ACT02613.1 - 0.05 14.1 0.0 0.18 12.3 0.0 2.0 1 0 0 1 1 1 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain PTS_IIB PF02302.17 ACT02613.1 - 0.57 10.9 5.5 4.3 8.1 0.1 2.8 3 1 0 3 3 3 0 PTS system, Lactose/Cellobiose specific IIB subunit BPD_transp_2 PF02653.16 ACT02614.1 - 2.2e-53 181.2 41.9 3.2e-53 180.6 41.9 1.2 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component Pam17 PF08566.10 ACT02614.1 - 4.2 7.2 9.7 6.5 6.6 3.2 2.4 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 ABC_tran PF00005.27 ACT02615.1 - 3.2e-53 179.9 0.1 4.2e-30 105.0 0.0 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACT02615.1 - 2.5e-13 50.5 0.5 0.0013 18.6 0.0 3.2 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 ACT02615.1 - 5.9e-06 25.4 3.1 0.076 11.8 0.3 4.2 4 1 0 4 4 4 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 ACT02615.1 - 1.8e-05 24.7 0.1 0.0023 17.9 0.1 3.1 4 0 0 4 4 4 1 RsgA GTPase AAA_29 PF13555.6 ACT02615.1 - 0.0003 20.5 0.4 0.0064 16.2 0.1 2.9 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ACT02615.1 - 0.0012 18.6 4.4 0.042 13.6 0.8 3.5 3 1 0 3 3 3 1 AAA domain SMC_N PF02463.19 ACT02615.1 - 0.0022 17.5 3.1 0.28 10.6 0.9 3.0 2 2 0 2 2 2 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ACT02615.1 - 0.0042 17.1 0.4 0.047 13.8 0.0 2.8 4 0 0 4 4 4 1 50S ribosome-binding GTPase AAA_23 PF13476.6 ACT02615.1 - 0.0052 17.3 0.4 0.018 15.6 0.1 2.0 3 0 0 3 3 2 1 AAA domain AAA_22 PF13401.6 ACT02615.1 - 0.0085 16.4 0.4 0.61 10.4 0.0 3.1 4 0 0 4 4 4 1 AAA domain AAA_16 PF13191.6 ACT02615.1 - 0.011 16.1 0.0 0.29 11.5 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain TsaE PF02367.17 ACT02615.1 - 0.012 15.6 0.8 5.7 7.0 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SbcCD_C PF13558.6 ACT02615.1 - 0.025 14.8 0.1 25 5.2 0.0 3.3 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.22 ACT02615.1 - 0.031 14.7 0.0 0.097 13.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA PF00004.29 ACT02615.1 - 0.043 14.2 2.2 0.87 10.0 0.2 3.3 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) Acid_phosphat_B PF03767.14 ACT02615.1 - 0.046 13.3 0.0 0.34 10.5 0.0 2.1 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) AhpC-TSA PF00578.21 ACT02615.1 - 0.095 12.6 0.0 9.3 6.2 0.0 2.3 2 0 0 2 2 2 0 AhpC/TSA family XS PF03468.14 ACT02615.1 - 0.11 12.9 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 XS domain FeoB_N PF02421.18 ACT02615.1 - 0.11 12.0 0.0 0.36 10.3 0.0 1.9 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_24 PF13479.6 ACT02615.1 - 0.12 12.1 0.4 6.2 6.5 0.0 2.6 3 1 0 3 3 3 0 AAA domain AAA_25 PF13481.6 ACT02615.1 - 0.15 11.6 0.1 0.56 9.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain ACT_7 PF13840.6 ACT02615.1 - 0.19 11.6 0.9 2.9 7.8 0.0 2.9 3 0 0 3 3 3 0 ACT domain AAA_13 PF13166.6 ACT02615.1 - 0.24 10.0 0.0 0.44 9.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain MukB PF04310.12 ACT02615.1 - 0.4 10.5 2.2 1.1 9.1 0.1 2.7 4 0 0 4 4 4 0 MukB N-terminal RbsD_FucU PF05025.13 ACT02616.1 - 2e-46 157.8 0.1 2.2e-46 157.6 0.1 1.0 1 0 0 1 1 1 1 RbsD / FucU transport protein family PfkB PF00294.24 ACT02617.1 - 4e-69 233.2 0.1 4.4e-69 233.1 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 ACT02617.1 - 2.1e-07 30.6 0.1 3e-06 26.8 0.1 2.2 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PreAtp-grasp PF18604.1 ACT02617.1 - 0.077 12.7 0.0 2.5 7.8 0.0 2.6 1 1 1 2 2 2 0 Pre ATP-grasp domain Peripla_BP_3 PF13377.6 ACT02618.1 - 5.6e-33 114.6 0.2 1.2e-32 113.5 0.2 1.6 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT02618.1 - 2.8e-21 76.2 0.0 3.5e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT02618.1 - 2.8e-21 75.0 0.3 6e-21 74.0 0.3 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACT02618.1 - 1.4e-18 67.4 0.0 3e-18 66.3 0.0 1.6 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_Tnp_ISL3 PF13542.6 ACT02618.1 - 0.0054 16.1 0.5 0.012 15.0 0.5 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_3 PF01381.22 ACT02618.1 - 0.017 15.2 0.0 0.068 13.2 0.0 1.9 1 1 1 2 2 2 0 Helix-turn-helix TetR_N PF00440.23 ACT02618.1 - 0.018 14.8 3.2 0.065 13.0 0.1 2.9 3 0 0 3 3 3 0 Bacterial regulatory proteins, tetR family HTH_38 PF13936.6 ACT02618.1 - 0.027 14.2 2.1 0.38 10.6 0.1 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_17 PF12728.7 ACT02618.1 - 0.028 14.6 0.1 0.083 13.1 0.1 1.8 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.6 ACT02618.1 - 0.037 13.6 0.1 0.18 11.4 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_31 PF13560.6 ACT02618.1 - 0.043 14.2 0.0 0.092 13.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 ACT02618.1 - 0.064 13.1 0.0 0.25 11.2 0.0 2.0 1 0 0 1 1 1 0 Homeodomain-like domain Trp_repressor PF01371.19 ACT02618.1 - 0.091 12.9 0.3 0.24 11.5 0.1 1.9 2 0 0 2 2 2 0 Trp repressor protein HTH_IclR PF09339.10 ACT02618.1 - 0.16 11.8 0.1 0.92 9.4 0.0 2.3 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT02618.1 - 0.18 11.8 0.7 1.1 9.3 0.0 2.5 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain LysR_substrate PF03466.20 ACT02619.1 - 8.7e-22 77.5 0.0 1.1e-21 77.1 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT02619.1 - 7.7e-20 70.6 0.7 1.5e-19 69.6 0.7 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Ribonuc_red_lgC PF02867.15 ACT02620.1 - 3.9e-133 444.8 0.0 1.3e-132 443.1 0.0 1.7 1 1 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 ACT02620.1 - 9.3e-05 22.4 0.0 0.0077 16.2 0.0 3.5 3 1 0 3 3 3 1 Ribonucleotide reductase, all-alpha domain Myosin_N PF02736.19 ACT02620.1 - 0.0036 17.1 2.1 0.0036 17.1 2.1 2.2 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain FdhE PF04216.12 ACT02620.1 - 0.091 12.6 2.0 0.2 11.5 2.0 1.5 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Zn_Tnp_IS1595 PF12760.7 ACT02620.1 - 0.18 11.8 2.4 0.41 10.6 2.4 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF2606 PF10794.9 ACT02620.1 - 0.18 11.6 0.1 0.4 10.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2606) SNF2_N PF00176.23 ACT02621.1 - 1.1e-35 123.0 0.1 2e-35 122.2 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ACT02621.1 - 4.1e-22 78.6 0.1 1.6e-21 76.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT02621.1 - 2.1e-11 44.1 0.3 5.6e-11 42.7 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ACT02621.1 - 9.8e-06 25.4 0.6 8.8e-05 22.3 0.1 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_34 PF13872.6 ACT02621.1 - 0.014 14.3 0.6 0.92 8.3 0.2 2.5 2 1 0 2 2 2 0 P-loop containing NTP hydrolase pore-1 DUF2075 PF09848.9 ACT02621.1 - 0.023 13.9 0.0 0.055 12.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Flavi_DEAD PF07652.14 ACT02621.1 - 0.044 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain Helicase_C_4 PF13871.6 ACT02621.1 - 0.075 12.7 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 C-terminal domain on Strawberry notch homologue SWI2_SNF2 PF18766.1 ACT02621.1 - 0.11 12.1 0.2 0.4 10.3 0.0 1.9 2 0 0 2 2 2 0 SWI2/SNF2 ATPase YqhG PF11079.8 ACT02622.1 - 4.3e-59 199.6 0.1 1.6e-35 122.4 0.0 2.1 2 0 0 2 2 2 2 Bacterial protein YqhG of unknown function YqzE PF14038.6 ACT02624.1 - 8.7e-23 80.1 0.0 9.7e-23 79.9 0.0 1.0 1 0 0 1 1 1 1 YqzE-like protein Amidase_3 PF01520.18 ACT02625.1 - 2.9e-34 118.7 0.0 3.7e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase Polysacc_deac_2 PF04748.13 ACT02626.1 - 4.2e-76 254.9 0.1 4.9e-76 254.6 0.1 1.0 1 0 0 1 1 1 1 Divergent polysaccharide deacetylase Pribosyltran PF00156.27 ACT02629.1 - 1.4e-11 44.1 0.2 2.1e-11 43.6 0.2 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF4309 PF14172.6 ACT02630.1 - 0.021 14.9 0.2 0.035 14.1 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4309) N36 PF11438.8 ACT02630.1 - 0.066 13.0 0.4 0.46 10.3 0.0 2.1 2 0 0 2 2 2 0 36-mer N-terminal peptide of the N protein (N36) AAA_27 PF13514.6 ACT02632.1 - 5.1e-17 62.2 4.0 5.1e-17 62.2 4.0 6.0 5 1 0 5 5 5 1 AAA domain SMC_N PF02463.19 ACT02632.1 - 5.8e-08 32.4 0.0 8.2e-07 28.7 0.0 2.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ACT02632.1 - 4.5e-07 30.6 35.4 4.5e-07 30.6 35.4 4.8 2 2 0 2 2 2 1 AAA domain AAA_15 PF13175.6 ACT02632.1 - 2.9e-05 24.0 0.0 0.0011 18.7 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain Phage_holin_3_6 PF07332.11 ACT02632.1 - 0.011 15.8 7.8 0.011 15.8 7.8 3.8 4 0 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III AAA_29 PF13555.6 ACT02632.1 - 0.019 14.7 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Metallophos PF00149.28 ACT02633.1 - 2.2e-15 57.7 0.1 4.9e-15 56.6 0.1 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACT02633.1 - 9.6e-09 35.6 0.0 2.7e-08 34.2 0.0 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Lactamase_B_3 PF13483.6 ACT02633.1 - 0.049 13.5 0.0 0.091 12.6 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Glycos_transf_1 PF00534.20 ACT02634.1 - 1e-33 116.3 0.0 1.5e-33 115.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT02634.1 - 5.5e-27 94.8 0.0 8.8e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACT02634.1 - 1.3e-15 57.8 0.0 4.3e-15 56.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACT02634.1 - 3e-10 40.8 0.0 1e-09 39.0 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ACT02634.1 - 4.5e-05 23.8 0.0 8.6e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 SopA PF13981.6 ACT02634.1 - 0.075 13.5 0.2 0.31 11.5 0.1 2.0 1 1 1 2 2 2 0 SopA-like central domain Glyco_trans_4_2 PF13477.6 ACT02634.1 - 0.092 12.8 0.0 0.27 11.3 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase 4-like GGDEF PF00990.21 ACT02635.1 - 4.3e-32 111.1 0.2 8.3e-32 110.2 0.2 1.5 1 1 0 1 1 1 1 Diguanylate cyclase, GGDEF domain IMS PF00817.20 ACT02635.1 - 0.022 14.8 0.0 0.05 13.6 0.0 1.5 1 1 0 1 1 1 0 impB/mucB/samB family HlyIII PF03006.20 ACT02635.1 - 0.22 11.2 10.3 0.49 10.1 10.3 1.5 1 0 0 1 1 1 0 Haemolysin-III related DUF1516 PF07457.11 ACT02635.1 - 2.6 8.3 13.6 8.6 6.6 13.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1516) HAD_2 PF13419.6 ACT02636.1 - 4.6e-30 105.0 0.0 5.4e-30 104.8 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT02636.1 - 1e-11 44.7 0.0 1.7e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ACT02636.1 - 1.3e-10 41.9 0.0 7.5e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT02636.1 - 1.4e-10 41.9 0.0 2e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ACT02636.1 - 2e-07 31.0 0.4 0.11 12.2 0.0 3.1 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ACT02636.1 - 0.089 12.9 0.0 0.46 10.6 0.0 2.1 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF2608 PF11019.8 ACT02636.1 - 0.2 11.1 0.1 1.3 8.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) HAD_2 PF13419.6 ACT02637.1 - 1.8e-26 93.4 0.0 5.7e-26 91.7 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT02637.1 - 1.3e-13 51.8 0.0 2e-13 51.1 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT02637.1 - 5.7e-09 35.9 0.0 1.1e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ACT02637.1 - 0.0003 21.3 0.1 0.00041 20.8 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ACT02637.1 - 0.047 13.8 0.0 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Radical_SAM PF04055.21 ACT02637.1 - 0.07 13.5 0.0 0.24 11.7 0.0 1.8 1 1 1 2 2 2 0 Radical SAM superfamily PhzC-PhzF PF02567.16 ACT02638.1 - 7.5e-65 219.2 0.0 1.2e-64 218.5 0.0 1.3 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein Cass2 PF14526.6 ACT02639.1 - 2.4e-26 92.7 0.3 2.6e-26 92.6 0.3 1.0 1 0 0 1 1 1 1 Integron-associated effector binding protein GyrI-like PF06445.15 ACT02639.1 - 2.9e-12 47.2 0.5 3.3e-12 47.0 0.5 1.0 1 0 0 1 1 1 1 GyrI-like small molecule binding domain Ribonuc_red_sm PF00268.21 ACT02640.1 - 3.2e-90 302.4 1.1 3.6e-90 302.2 1.1 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Ribonuc_red_lgC PF02867.15 ACT02641.1 - 5.1e-130 434.5 10.1 4.9e-128 427.9 10.1 2.3 1 1 0 1 1 1 1 Ribonucleotide reductase, barrel domain RNR_N PF08343.10 ACT02641.1 - 1.1e-18 67.0 2.0 1.1e-18 67.0 2.0 3.0 3 0 0 3 3 3 1 Ribonucleotide reductase N-terminal Ribonuc_red_lgN PF00317.21 ACT02641.1 - 6.6e-13 48.5 0.3 4.4e-12 45.8 0.1 2.5 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain Flavodoxin_NdrI PF07972.11 ACT02642.1 - 5.4e-31 107.2 0.1 7.1e-31 106.9 0.1 1.2 1 0 0 1 1 1 1 NrdI Flavodoxin like NRBF2 PF08961.10 ACT02643.1 - 0.0055 16.3 0.1 0.0055 16.3 0.1 1.2 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator HALZ PF02183.18 ACT02643.1 - 0.015 15.5 0.3 0.034 14.4 0.3 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF1192 PF06698.11 ACT02643.1 - 0.027 14.5 0.0 0.056 13.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) TK PF00265.18 ACT02644.1 - 5.2e-41 140.4 0.0 6e-41 140.2 0.0 1.0 1 0 0 1 1 1 1 Thymidine kinase Exo_endo_phos PF03372.23 ACT02644.1 - 0.19 11.2 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Methyltransf_25 PF13649.6 ACT02645.1 - 6.4e-17 62.1 0.0 1.1e-16 61.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT02645.1 - 2.6e-13 50.4 0.0 4.7e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT02645.1 - 3.7e-11 43.1 0.0 5e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT02645.1 - 3.2e-10 40.6 0.0 5.7e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT02645.1 - 2.3e-09 37.3 0.0 3.1e-09 36.9 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ACT02645.1 - 8.1e-06 25.3 0.0 1.2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 ACT02645.1 - 2e-05 24.2 0.0 3.2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 ACT02645.1 - 8.1e-05 22.1 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 ACT02645.1 - 0.00078 18.9 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 ACT02645.1 - 0.0021 18.0 0.0 0.003 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 ACT02645.1 - 0.0037 16.9 0.0 0.0054 16.4 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) TehB PF03848.14 ACT02645.1 - 0.058 12.8 0.0 0.08 12.3 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_16 PF10294.9 ACT02645.1 - 0.062 13.0 0.0 0.089 12.5 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_24 PF13578.6 ACT02645.1 - 0.074 14.1 0.0 0.21 12.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 ACT02645.1 - 0.079 12.0 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase AdoMet_MTase PF07757.13 ACT02645.1 - 0.081 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase S1_2 PF13509.6 ACT02646.1 - 5.6e-22 77.6 0.0 1.7e-15 56.8 0.1 2.5 2 0 0 2 2 2 2 S1 domain CvfB_WH PF17783.1 ACT02646.1 - 2.9e-19 68.6 0.0 4.5e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 CvfB-like winged helix domain S1 PF00575.23 ACT02646.1 - 1.1e-05 25.7 0.1 0.052 13.9 0.0 3.4 3 1 0 3 3 3 2 S1 RNA binding domain MarR_2 PF12802.7 ACT02646.1 - 0.00016 21.5 0.0 0.00037 20.3 0.0 1.6 1 0 0 1 1 1 1 MarR family HemN_C PF06969.16 ACT02646.1 - 0.0038 17.3 0.0 0.037 14.1 0.0 2.2 2 0 0 2 2 2 1 HemN C-terminal domain HTH_24 PF13412.6 ACT02646.1 - 0.0065 16.0 0.0 0.026 14.1 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 ACT02646.1 - 0.078 12.9 0.0 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB BLACT_WH PF17778.1 ACT02646.1 - 0.19 11.7 0.5 23 5.1 0.1 2.4 2 0 0 2 2 2 0 Beta-lactamase associated winged helix domain RsfS PF02410.15 ACT02647.1 - 1.9e-25 89.2 0.7 2.2e-25 88.9 0.7 1.0 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation SH3_14 PF18343.1 ACT02647.1 - 0.082 13.0 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Dda helicase SH3 domain HD PF01966.22 ACT02648.1 - 1.7e-13 50.9 0.3 2.2e-13 50.5 0.3 1.1 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 ACT02648.1 - 0.029 13.9 0.1 0.074 12.5 0.1 1.6 2 0 0 2 2 2 0 HDOD domain CTP_transf_like PF01467.26 ACT02649.1 - 2.8e-27 95.6 0.0 3.3e-27 95.4 0.0 1.0 1 0 0 1 1 1 1 Cytidylyltransferase-like CRS1_YhbY PF01985.21 ACT02650.1 - 2.8e-23 81.9 0.2 3.3e-23 81.6 0.2 1.1 1 0 0 1 1 1 1 CRS1 / YhbY (CRM) domain Shikimate_dh_N PF08501.11 ACT02651.1 - 5.4e-31 106.7 0.0 9.2e-31 105.9 0.0 1.4 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.20 ACT02651.1 - 5.1e-15 55.7 0.1 1.3e-14 54.4 0.0 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase SDH_C PF18317.1 ACT02651.1 - 9.8e-15 54.0 1.7 1.8e-14 53.2 1.7 1.5 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 ACT02651.1 - 3.9e-07 30.4 0.1 6.7e-07 29.6 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 ACT02651.1 - 2.1e-05 25.0 0.3 3.8e-05 24.2 0.3 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent OCD_Mu_crystall PF02423.15 ACT02651.1 - 8.2e-05 21.7 0.1 0.00012 21.2 0.1 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Glyco_hydro_4 PF02056.16 ACT02651.1 - 0.021 14.4 0.0 1 8.9 0.0 2.2 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase AlaDh_PNT_C PF01262.21 ACT02651.1 - 0.026 13.8 0.1 0.041 13.2 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 ACT02651.1 - 0.12 12.8 0.1 0.2 12.1 0.1 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding MMR_HSR1 PF01926.23 ACT02652.1 - 3.6e-14 52.8 0.0 1.2e-13 51.1 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ACT02652.1 - 1.6e-12 47.6 0.0 2.6e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 ACT02652.1 - 3.7e-09 36.3 0.1 3.6e-05 23.3 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 ACT02652.1 - 5.4e-07 29.3 1.1 0.0082 15.7 0.1 2.6 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Ras PF00071.22 ACT02652.1 - 1.2e-05 25.0 0.0 0.087 12.4 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ACT02652.1 - 6.5e-05 23.1 0.0 0.019 15.2 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 ACT02652.1 - 0.00036 19.6 0.1 0.031 13.3 0.0 2.1 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 ACT02652.1 - 0.00053 20.1 0.5 0.027 14.5 0.0 2.5 2 1 1 3 3 2 1 Dynamin family PduV-EutP PF10662.9 ACT02652.1 - 0.0036 17.0 0.1 0.67 9.7 0.0 2.6 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 ACT02652.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein G-alpha PF00503.20 ACT02652.1 - 0.035 13.3 0.0 3.8 6.6 0.0 2.1 1 1 1 2 2 2 0 G-protein alpha subunit RNA_helicase PF00910.22 ACT02652.1 - 0.037 14.4 0.0 0.077 13.4 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 ACT02652.1 - 0.042 14.1 0.0 0.89 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 ACT02652.1 - 0.045 13.2 0.1 4.4 6.7 0.0 2.2 1 1 1 2 2 2 0 ADP-ribosylation factor family cobW PF02492.19 ACT02652.1 - 0.047 13.3 0.0 3.3 7.3 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.10 ACT02652.1 - 0.08 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ACT02652.1 - 0.086 13.2 0.0 0.4 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain ATPase_2 PF01637.18 ACT02652.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PGP_phosphatase PF09419.10 ACT02653.1 - 1.3e-10 41.2 0.0 5.7e-10 39.1 0.0 1.8 1 1 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 ACT02653.1 - 1.9e-10 40.6 0.0 3.7e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 ACT02653.1 - 1.2e-08 35.2 0.0 1.8e-07 31.4 0.0 2.5 1 1 1 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT02653.1 - 8.2e-07 29.5 0.0 1.1e-06 29.1 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ACT02653.1 - 0.0002 21.2 0.0 0.001 18.9 0.0 1.8 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ACT02653.1 - 0.0045 17.1 0.0 0.01 15.9 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase S6PP PF05116.13 ACT02653.1 - 0.012 15.2 0.0 0.037 13.5 0.0 1.7 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.7 ACT02653.1 - 0.032 14.6 0.0 0.086 13.2 0.0 1.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase AhpC-TSA PF00578.21 ACT02653.1 - 0.076 12.9 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family NIF PF03031.18 ACT02653.1 - 0.13 12.0 0.0 0.72 9.6 0.0 2.1 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase DUF705 PF05152.12 ACT02653.1 - 0.17 11.3 0.0 0.22 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF705) Transglut_core PF01841.19 ACT02654.1 - 3.7e-25 88.6 0.0 6.8e-25 87.7 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF4129 PF13559.6 ACT02654.1 - 0.022 15.0 0.0 0.06 13.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) DUF5098 PF17023.5 ACT02654.1 - 0.024 13.6 0.1 0.032 13.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5098) DUF58 PF01882.18 ACT02655.1 - 3.6e-18 65.6 0.0 7.5e-18 64.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function DUF58 AAA_3 PF07726.11 ACT02656.1 - 1.6e-61 205.9 0.1 3.2e-61 205.0 0.1 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 ACT02656.1 - 1.8e-22 78.9 1.9 3.5e-22 78.0 1.9 1.5 1 0 0 1 1 1 1 AAA lid domain AAA_5 PF07728.14 ACT02656.1 - 8.2e-16 58.3 0.0 5e-15 55.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) MCM PF00493.23 ACT02656.1 - 6.8e-09 35.2 0.0 1.1e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain AAA PF00004.29 ACT02656.1 - 5.4e-07 30.1 0.0 2.5e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ACT02656.1 - 1.5e-06 27.7 0.2 0.026 13.9 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 ACT02656.1 - 3.6e-05 23.5 0.2 0.00084 19.1 0.1 2.7 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 ACT02656.1 - 0.0029 17.4 0.0 0.14 11.9 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 ACT02656.1 - 0.0085 16.5 0.1 0.034 14.5 0.1 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 ACT02656.1 - 0.014 15.1 1.3 0.63 9.7 0.0 2.7 3 1 0 3 3 3 0 AAA domain AAA_19 PF13245.6 ACT02656.1 - 0.014 15.7 0.2 2.9 8.2 0.1 2.6 3 0 0 3 3 3 0 AAA domain AAA_6 PF12774.7 ACT02656.1 - 0.13 11.2 0.0 0.23 10.4 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region TsaE PF02367.17 ACT02656.1 - 0.17 11.9 0.1 0.44 10.6 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2156 PF09924.9 ACT02657.1 - 4.3e-94 314.9 0.1 6.2e-94 314.3 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) LPG_synthase_TM PF03706.13 ACT02657.1 - 4.8e-22 78.9 32.9 4.8e-22 78.9 32.9 3.2 2 1 0 2 2 2 1 Lysylphosphatidylglycerol synthase TM region SpoVAC_SpoVAEB PF03862.13 ACT02658.1 - 2.1e-40 137.6 11.4 2.3e-40 137.4 11.4 1.0 1 0 0 1 1 1 1 SpoVAC/SpoVAEB sporulation membrane protein DUF588 PF04535.12 ACT02658.1 - 0.079 12.7 3.5 0.1 12.4 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF588) SpoVAD PF07451.11 ACT02659.1 - 1.8e-155 516.7 0.2 2e-155 516.5 0.2 1.0 1 0 0 1 1 1 1 Stage V sporulation protein AD (SpoVAD) ACP_syn_III PF08545.10 ACT02659.1 - 0.022 14.6 5.9 4.2 7.3 3.4 3.4 2 1 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 ACT02659.1 - 0.15 11.6 7.9 0.22 11.1 2.3 2.6 2 1 1 3 3 3 0 Beta-ketoacyl synthase, N-terminal domain SpoVAC_SpoVAEB PF03862.13 ACT02660.1 - 1.8e-39 134.6 9.6 2.2e-39 134.3 9.6 1.1 1 0 0 1 1 1 1 SpoVAC/SpoVAEB sporulation membrane protein Cation_efflux PF01545.21 ACT02660.1 - 0.02 14.6 3.8 0.051 13.3 3.8 1.7 1 1 0 1 1 1 0 Cation efflux family SecE PF00584.20 ACT02660.1 - 3.4 7.7 5.3 41 4.2 1.7 2.5 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex SpoVAC_SpoVAEB PF03862.13 ACT02661.1 - 3.6e-40 136.8 13.0 4.1e-40 136.6 13.0 1.0 1 0 0 1 1 1 1 SpoVAC/SpoVAEB sporulation membrane protein DUF588 PF04535.12 ACT02661.1 - 0.0011 18.8 0.9 0.0013 18.5 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF588) SpoVAD PF07451.11 ACT02662.1 - 2.7e-156 519.4 0.5 3.1e-156 519.2 0.5 1.0 1 0 0 1 1 1 1 Stage V sporulation protein AD (SpoVAD) LBP_BPI_CETP PF01273.25 ACT02662.1 - 0.016 14.8 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain SpoVAC_SpoVAEB PF03862.13 ACT02663.1 - 1.9e-41 140.9 8.6 2.3e-41 140.7 8.6 1.1 1 0 0 1 1 1 1 SpoVAC/SpoVAEB sporulation membrane protein SecE PF00584.20 ACT02663.1 - 0.033 14.1 0.8 1.9 8.5 1.0 2.6 3 0 0 3 3 3 0 SecE/Sec61-gamma subunits of protein translocation complex Vma12 PF11712.8 ACT02663.1 - 0.19 11.8 0.5 0.43 10.7 0.5 1.6 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF3040 PF11239.8 ACT02663.1 - 2.3 8.5 9.3 31 4.9 0.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3040) DUF421 PF04239.12 ACT02664.1 - 6.8e-33 112.7 0.0 1e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF421) DUF1657 PF07870.11 ACT02664.1 - 1e-17 63.7 0.5 1.6e-17 63.1 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1657) NurA PF09376.10 ACT02664.1 - 0.05 13.3 0.0 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 NurA domain RIO1 PF01163.22 ACT02664.1 - 0.082 12.5 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 RIO1 family Dynamin_M PF01031.20 ACT02664.1 - 0.11 11.6 0.1 0.19 10.9 0.1 1.3 1 0 0 1 1 1 0 Dynamin central region DUF4131 PF13567.6 ACT02664.1 - 0.21 11.2 0.7 3 7.5 0.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF1657 PF07870.11 ACT02665.1 - 7.9e-22 76.9 5.0 9.7e-22 76.6 5.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1657) DUF2383 PF09537.10 ACT02665.1 - 0.0043 17.4 0.4 0.0043 17.4 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2383) Coat_F PF07875.12 ACT02665.1 - 0.081 13.2 1.0 0.1 12.8 1.0 1.1 1 0 0 1 1 1 0 Coat F domain DUF2264 PF10022.9 ACT02666.1 - 1.6e-124 415.6 0.1 2e-124 415.3 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) Glyco_hydro_88 PF07470.13 ACT02667.1 - 2.5e-17 63.0 0.0 3.4e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Hepar_II_III PF07940.13 ACT02668.1 - 7.7e-05 22.4 0.0 0.00012 21.8 0.0 1.3 1 0 0 1 1 1 1 Heparinase II/III-like protein Response_reg PF00072.24 ACT02669.1 - 1.6e-23 83.0 0.2 3.4e-23 81.9 0.2 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT02669.1 - 5.4e-23 80.6 0.2 1.5e-10 40.8 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT02669.1 - 5.7e-23 81.0 0.0 1.2e-22 79.9 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 ACT02669.1 - 0.0086 15.8 0.0 0.87 9.5 0.0 3.0 3 0 0 3 3 3 1 Homeodomain-like domain Sigma70_r3 PF04539.16 ACT02669.1 - 0.062 13.4 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 Sigma-70 region 3 His_kinase PF06580.13 ACT02670.1 - 1.3e-23 83.2 2.1 1.3e-23 83.2 2.1 2.4 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT02670.1 - 1.8e-18 67.2 6.8 3.2e-18 66.4 6.8 1.4 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT02670.1 - 3.5e-12 46.8 0.1 7.1e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT02670.1 - 9.2e-12 45.2 0.3 3.9e-11 43.1 0.1 2.3 2 0 0 2 2 2 1 HAMP domain HATPase_c_3 PF13589.6 ACT02670.1 - 0.00011 22.1 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT02670.1 - 0.019 14.9 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain DUF3708 PF12501.8 ACT02670.1 - 0.037 13.8 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter SBP_bac_1 PF01547.25 ACT02671.1 - 1.1e-27 97.9 13.3 1.8e-27 97.1 13.3 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT02672.1 - 4.3e-18 65.7 14.9 4.3e-18 65.7 14.9 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component IPTL-CTERM PF18203.1 ACT02672.1 - 0.16 11.9 0.2 0.16 11.9 0.2 2.2 3 0 0 3 3 3 0 IPTL-CTERM motif BPD_transp_1 PF00528.22 ACT02673.1 - 5.1e-17 62.2 28.2 5.1e-17 62.2 28.2 2.4 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2434 PF10361.9 ACT02673.1 - 0.0037 16.3 0.6 0.0037 16.3 0.6 2.9 2 1 1 3 3 3 1 Protein of unknown function (DUF2434) CrgA PF06781.12 ACT02673.1 - 0.25 11.4 0.1 0.25 11.4 0.1 3.6 3 1 1 4 4 4 0 Cell division protein CrgA HEAT_2 PF13646.6 ACT02674.1 - 0.00039 20.7 0.0 0.009 16.4 0.0 2.4 2 0 0 2 2 2 1 HEAT repeats zf-H2C2_2 PF13465.6 ACT02675.1 - 6.2e-05 23.2 2.4 0.29 11.7 0.7 2.2 2 0 0 2 2 2 2 Zinc-finger double domain PhnA_Zn_Ribbon PF08274.12 ACT02675.1 - 0.0033 17.3 0.0 0.086 12.8 0.0 1.6 1 1 1 2 2 2 2 PhnA Zinc-Ribbon zf-Di19 PF05605.12 ACT02675.1 - 0.0051 17.1 1.6 0.15 12.4 2.6 2.0 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding Zn_Tnp_IS1595 PF12760.7 ACT02675.1 - 0.0058 16.6 3.5 0.62 10.1 0.3 2.2 1 1 1 2 2 2 2 Transposase zinc-ribbon domain zf-RING_4 PF14570.6 ACT02675.1 - 0.0065 16.2 0.5 0.056 13.3 0.1 2.1 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-Sec23_Sec24 PF04810.15 ACT02675.1 - 0.0072 16.4 0.1 2.3 8.3 0.0 2.2 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger zinc_ribbon_5 PF13719.6 ACT02675.1 - 0.008 15.9 3.6 0.029 14.1 0.5 2.2 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_9 PF14369.6 ACT02675.1 - 0.01 16.1 0.4 2.8 8.3 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon HypA PF01155.19 ACT02675.1 - 0.017 15.1 0.0 0.02 14.9 0.0 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TF_Zn_Ribbon PF08271.12 ACT02675.1 - 0.03 13.9 1.4 2.2 7.8 0.1 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding DZR PF12773.7 ACT02675.1 - 0.039 14.0 0.2 0.065 13.3 0.2 1.3 1 1 0 1 1 1 0 Double zinc ribbon CpXC PF14353.6 ACT02675.1 - 0.041 13.9 1.3 3.7 7.6 0.1 2.1 1 1 1 2 2 2 0 CpXC protein zinc_ribbon_4 PF13717.6 ACT02675.1 - 0.042 13.8 2.9 2.2 8.3 3.0 2.2 1 1 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 ACT02675.1 - 0.042 14.0 0.9 0.14 12.3 0.9 1.8 1 1 0 1 1 1 0 Zinc ribbon domain zf-RING_5 PF14634.6 ACT02675.1 - 0.043 13.8 0.9 0.083 12.9 0.9 1.5 1 1 0 1 1 1 0 zinc-RING finger domain Rad50_zn_hook PF04423.14 ACT02675.1 - 0.054 13.3 0.2 9.5 6.1 0.0 2.1 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RRN7 PF11781.8 ACT02675.1 - 0.056 13.1 0.7 2.8 7.7 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Cys_rich_KTR PF14205.6 ACT02675.1 - 0.088 12.6 0.7 3.1 7.7 0.1 2.2 2 0 0 2 2 2 0 Cysteine-rich KTR zinc_ribbon_2 PF13240.6 ACT02675.1 - 0.13 12.1 2.0 2.2 8.1 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Baculo_IE-1 PF05290.11 ACT02675.1 - 0.17 11.8 1.9 0.2 11.6 0.2 1.8 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) YacG PF03884.14 ACT02675.1 - 0.21 11.3 1.6 9.9 6.0 0.0 2.2 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG Prok-RING_1 PF14446.6 ACT02675.1 - 0.22 11.5 4.0 1.8 8.5 4.0 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Ribosomal_L37e PF01907.19 ACT02675.1 - 0.22 11.7 1.3 2.2 8.5 0.2 2.0 2 0 0 2 2 2 0 Ribosomal protein L37e Rubredoxin PF00301.20 ACT02675.1 - 0.24 11.5 2.1 5.3 7.1 0.1 2.2 2 0 0 2 2 2 0 Rubredoxin Zn-C2H2_12 PF18112.1 ACT02675.1 - 0.25 11.9 3.9 10 6.7 0.4 2.4 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf_UBZ PF18439.1 ACT02675.1 - 0.33 10.6 0.9 1.7 8.3 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger OrfB_Zn_ribbon PF07282.11 ACT02675.1 - 0.46 10.4 2.5 3.7 7.5 0.2 2.1 1 1 0 2 2 2 0 Putative transposase DNA-binding domain zf-C2H2_4 PF13894.6 ACT02675.1 - 0.85 10.6 3.5 10 7.3 0.6 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger DNA_ligase_ZBD PF03119.16 ACT02675.1 - 1.4 9.0 5.9 2.1 8.5 0.6 2.2 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Cyclase PF04199.13 ACT02676.1 - 1.1e-13 51.6 0.0 1.5e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase HTH_18 PF12833.7 ACT02677.1 - 1.1e-17 64.1 0.4 1.6e-17 63.5 0.4 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain GyrI-like PF06445.15 ACT02677.1 - 1.5e-17 64.3 2.1 2.6e-17 63.6 2.1 1.4 1 0 0 1 1 1 1 GyrI-like small molecule binding domain Cass2 PF14526.6 ACT02677.1 - 3.8e-16 59.6 1.5 3.8e-16 59.6 1.5 1.4 2 0 0 2 2 2 1 Integron-associated effector binding protein HTH_AraC PF00165.23 ACT02677.1 - 6.3e-07 29.3 0.2 1.8e-05 24.7 0.0 2.4 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix proteins, AraC family Glyco_hydr_116N PF12215.8 ACT02677.1 - 0.037 13.5 0.0 0.053 13.0 0.0 1.2 1 0 0 1 1 1 0 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Acetyltransf_1 PF00583.25 ACT02678.1 - 2.4e-17 63.2 0.0 3e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT02678.1 - 1.4e-11 44.4 0.0 1.8e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT02678.1 - 2.5e-11 43.8 0.0 3.6e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT02678.1 - 2.8e-07 30.4 0.0 1.2e-06 28.4 0.0 1.8 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 ACT02678.1 - 4.8e-07 30.5 0.0 5.4e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ACT02678.1 - 0.00017 21.3 0.0 0.00026 20.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ACT02678.1 - 0.01 15.8 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 ACT02678.1 - 0.012 15.1 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_9 PF13527.7 ACT02678.1 - 0.029 14.4 0.0 0.048 13.7 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACT02678.1 - 0.037 14.2 0.0 0.05 13.7 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain MCM6_C PF18263.1 ACT02678.1 - 0.083 13.1 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 MCM6 C-terminal winged-helix domain Acetyltransf_CG PF14542.6 ACT02678.1 - 0.14 12.3 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Hydrolase_like PF13242.6 ACT02679.1 - 4.9e-16 58.6 0.0 8e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 ACT02679.1 - 1.9e-07 31.3 0.0 4.9e-07 30.0 0.0 1.7 1 1 1 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT02679.1 - 2.1e-06 28.2 0.0 8.4e-06 26.2 0.0 1.9 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 ACT02679.1 - 0.0037 16.9 0.0 0.0078 15.8 0.0 1.6 1 1 0 1 1 1 1 Mitochondrial PGP phosphatase PNK3P PF08645.11 ACT02679.1 - 0.024 14.3 0.0 0.035 13.8 0.0 1.5 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase Hydrolase_6 PF13344.6 ACT02679.1 - 0.048 13.8 0.0 0.11 12.6 0.0 1.9 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Big_2 PF02368.18 ACT02681.1 - 1.8e-30 104.6 84.1 5.6e-07 29.4 4.9 8.3 7 1 1 8 8 8 7 Bacterial Ig-like domain (group 2) YbaB_DNA_bd PF02575.16 ACT02681.1 - 0.015 15.5 7.0 2 8.7 0.1 4.7 5 0 0 5 5 5 0 YbaB/EbfC DNA-binding family Big_3 PF07523.12 ACT02681.1 - 0.026 14.8 47.1 0.16 12.3 1.7 7.9 8 2 0 8 8 8 0 Bacterial Ig-like domain (group 3) dCMP_cyt_deam_1 PF00383.23 ACT02682.1 - 2.4e-19 69.1 0.0 3.1e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ACT02682.1 - 2e-18 66.4 0.0 2.1e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 ACT02682.1 - 8.6e-05 22.6 0.1 0.00014 21.9 0.1 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 ACT02682.1 - 0.0023 18.0 0.1 0.0031 17.6 0.1 1.2 1 0 0 1 1 1 1 APOBEC2 APOBEC_N PF08210.11 ACT02682.1 - 0.0026 17.7 0.1 0.0032 17.4 0.1 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain NAD1 PF18778.1 ACT02682.1 - 0.0035 17.4 0.1 0.0051 16.9 0.1 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 NAD2 PF18782.1 ACT02682.1 - 0.0064 16.6 0.0 0.0087 16.2 0.0 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 Bd3614-deam PF14439.6 ACT02682.1 - 0.18 11.9 0.8 9.7 6.3 0.5 2.2 1 1 1 2 2 2 0 Bd3614-like deaminase MgtC PF02308.16 ACT02683.1 - 2.2e-35 121.6 10.3 2.9e-35 121.3 10.3 1.1 1 0 0 1 1 1 1 MgtC family ACT_4 PF13291.6 ACT02683.1 - 0.00013 22.4 0.1 0.00021 21.8 0.1 1.3 1 0 0 1 1 1 1 ACT domain SLH PF00395.20 ACT02684.1 - 1.7e-41 139.9 4.1 8.7e-14 51.3 0.1 4.5 3 0 0 3 3 3 3 S-layer homology domain RicinB_lectin_2 PF14200.6 ACT02684.1 - 3.2e-26 91.9 33.1 0.0038 17.9 0.0 12.0 6 5 7 13 13 13 12 Ricin-type beta-trefoil lectin domain-like Pectate_lyase_3 PF12708.7 ACT02684.1 - 1.7e-18 67.3 0.1 1.7e-18 67.3 0.1 3.6 2 1 1 3 3 3 1 Pectate lyase superfamily protein CBM_35 PF16990.5 ACT02684.1 - 6.7e-08 32.8 1.0 6.7e-08 32.8 1.0 2.7 2 0 0 2 2 2 1 Carbohydrate binding module (family 35) Fascin PF06268.13 ACT02684.1 - 2.3e-06 27.8 0.9 19 5.5 0.0 6.7 7 0 0 7 7 7 3 Fascin domain Beta_helix PF13229.6 ACT02684.1 - 1.5e-05 24.9 20.5 9.9e-05 22.2 0.3 4.0 3 1 2 5 5 5 3 Right handed beta helix region Big_3 PF07523.12 ACT02684.1 - 0.13 12.6 7.2 12 6.3 0.1 4.2 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) MFS_1 PF07690.16 ACT02685.1 - 7.9e-58 196.1 51.2 7.9e-58 196.1 51.2 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT02685.1 - 0.0043 16.0 12.9 0.0043 16.0 12.9 3.6 1 1 0 3 3 3 2 Sugar (and other) transporter MLTR_LBD PF17765.1 ACT02686.1 - 9.1e-43 146.3 0.1 1.5e-42 145.6 0.1 1.4 1 0 0 1 1 1 1 MmyB-like transcription regulator ligand binding domain HTH_31 PF13560.6 ACT02686.1 - 5.7e-15 55.4 3.4 1.4e-14 54.1 3.4 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain Response_reg PF00072.24 ACT02688.1 - 4.8e-28 97.6 0.0 9.5e-28 96.6 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02688.1 - 1.5e-17 63.6 0.0 3.4e-17 62.5 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02688.1 - 1.8e-16 59.7 0.0 1.9e-07 31.0 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT02688.1 - 4.8e-12 46.2 0.0 1.3e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 GGDEF-like domain DUF5113 PF17140.4 ACT02688.1 - 0.057 13.2 0.3 1.2 8.9 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5113) Serum_albumin PF00273.20 ACT02688.1 - 0.1 12.4 1.0 0.19 11.5 1.0 1.4 1 0 0 1 1 1 0 Serum albumin family His_kinase PF06580.13 ACT02689.1 - 2.3e-26 91.9 0.1 7.1e-26 90.3 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT02689.1 - 1.4e-19 70.9 0.4 2e-19 70.4 0.4 1.2 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 ACT02689.1 - 9e-11 42.0 0.0 2.3e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT02689.1 - 5e-08 33.4 0.1 1.3e-07 32.1 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT02689.1 - 0.003 17.5 0.0 0.0066 16.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACT02689.1 - 0.024 14.5 0.1 0.045 13.6 0.1 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT02689.1 - 0.1 12.5 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 GHKL domain LapA_dom PF06305.11 ACT02689.1 - 1.2 9.0 7.1 3.3 7.6 0.4 3.2 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain SBP_bac_8 PF13416.6 ACT02690.1 - 6.6e-32 111.5 5.3 8.8e-32 111.0 5.3 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02690.1 - 1.5e-24 87.6 7.6 2e-24 87.1 7.6 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Glyco_hydro_43 PF04616.14 ACT02691.1 - 4.1e-48 164.2 5.8 5.4e-48 163.8 5.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 CBM_6 PF03422.15 ACT02691.1 - 1.1e-08 35.4 0.6 7.4e-08 32.7 0.1 2.6 3 0 0 3 3 3 1 Carbohydrate binding module (family 6) CBM_35 PF16990.5 ACT02691.1 - 9.5e-08 32.3 0.2 0.0013 19.0 0.1 2.7 1 1 1 2 2 2 2 Carbohydrate binding module (family 35) BclA_C PF18573.1 ACT02691.1 - 0.022 14.7 0.2 0.29 11.1 0.0 2.4 2 0 0 2 2 2 0 BclA C-terminal domain Glucodextran_B PF09136.10 ACT02691.1 - 0.036 14.4 0.2 0.24 11.8 0.1 2.3 2 0 0 2 2 2 0 Glucodextranase, domain B C1q PF00386.21 ACT02691.1 - 0.1 12.8 0.1 0.75 10.0 0.0 2.3 2 0 0 2 2 2 0 C1q domain BPD_transp_1 PF00528.22 ACT02692.1 - 1.6e-19 70.4 18.8 1.6e-19 70.4 18.8 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Endomucin PF07010.12 ACT02692.1 - 0.21 11.6 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Endomucin LPAM_1 PF08139.12 ACT02692.1 - 0.21 12.1 1.8 2.1 9.0 1.8 2.9 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site BPD_transp_1 PF00528.22 ACT02693.1 - 9.5e-24 84.1 17.3 9.5e-24 84.1 17.3 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACT02694.1 - 6.3e-35 121.4 9.8 8.8e-35 120.9 9.8 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02694.1 - 1.8e-31 110.3 16.2 3.1e-31 109.5 16.2 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Glyco_hydro_2_N PF02837.18 ACT02695.1 - 2.8e-21 76.2 1.0 6.6e-21 74.9 1.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 ACT02695.1 - 8.4e-15 54.7 0.2 6.3e-13 48.5 0.2 2.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ACT02695.1 - 1.8e-09 38.2 0.0 3.1e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 ACT02695.1 - 5.3e-06 27.0 0.2 1.4e-05 25.7 0.1 1.7 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain HTH_5 PF01022.20 ACT02696.1 - 1e-09 38.1 0.1 2e-09 37.1 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACT02696.1 - 3.1e-09 36.7 0.0 7.5e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 ACT02696.1 - 1.5e-08 34.0 0.1 3.5e-08 32.9 0.1 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ACT02696.1 - 1.1e-07 31.6 0.0 3e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 MarR family MarR PF01047.22 ACT02696.1 - 3.6e-07 30.0 0.1 7.4e-07 29.0 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 ACT02696.1 - 3.9e-06 26.7 0.1 7e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 HTH domain TrmB PF01978.19 ACT02696.1 - 0.00022 21.0 0.0 0.00041 20.2 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Fe_dep_repress PF01325.19 ACT02696.1 - 0.00037 20.6 0.7 0.00058 20.0 0.1 1.7 2 0 0 2 2 1 1 Iron dependent repressor, N-terminal DNA binding domain Rrf2 PF02082.20 ACT02696.1 - 0.00054 20.3 0.0 0.0013 19.0 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulator HTH_28 PF13518.6 ACT02696.1 - 0.00065 19.8 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_IclR PF09339.10 ACT02696.1 - 0.00085 19.1 0.0 0.0018 18.0 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT02696.1 - 0.0012 18.8 0.1 0.0025 17.8 0.1 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_AsnC-type PF13404.6 ACT02696.1 - 0.0013 18.5 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_29 PF13551.6 ACT02696.1 - 0.0036 17.3 0.0 0.0062 16.5 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_DeoR PF08220.12 ACT02696.1 - 0.016 15.0 0.0 0.043 13.6 0.0 1.8 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain HTH_Mga PF08280.11 ACT02696.1 - 0.028 14.4 0.0 0.071 13.2 0.0 1.6 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_10 PF04967.12 ACT02696.1 - 0.037 13.8 0.1 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 HTH DNA binding domain HTH_27 PF13463.6 ACT02696.1 - 0.08 13.4 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain ArsR PF09824.9 ACT02696.1 - 0.087 12.4 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 ArsR transcriptional regulator HTH_41 PF14502.6 ACT02696.1 - 0.11 12.2 0.4 0.27 11.0 0.4 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Glyco_hydro_127 PF07944.12 ACT02697.1 - 8.4e-50 169.7 0.0 1.1e-49 169.4 0.0 1.1 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 B9-C2 PF07162.11 ACT02697.1 - 0.012 15.8 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 Ciliary basal body-associated, B9 protein Glyco_hydro_43 PF04616.14 ACT02698.1 - 2.2e-42 145.3 6.4 4.4e-42 144.4 6.4 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 CBM_6 PF03422.15 ACT02698.1 - 3.3e-13 50.0 3.0 3.3e-13 50.0 3.0 4.4 3 1 1 4 4 4 1 Carbohydrate binding module (family 6) DUF1080 PF06439.11 ACT02698.1 - 3e-12 47.1 2.0 3e-12 47.1 2.0 3.5 2 1 1 3 3 3 1 Domain of Unknown Function (DUF1080) DUF5010_C PF18099.1 ACT02698.1 - 2.6e-10 40.4 5.6 3.2e-10 40.1 0.6 3.3 3 0 0 3 3 3 1 DUF5010 C-terminal domain Laminin_G_2 PF02210.24 ACT02698.1 - 2.8e-06 27.9 0.3 0.093 13.3 0.0 3.1 2 1 1 3 3 3 2 Laminin G domain Laminin_G_1 PF00054.23 ACT02698.1 - 9.5e-06 25.9 0.1 0.37 11.0 0.0 3.1 3 0 0 3 3 3 2 Laminin G domain Laminin_G_3 PF13385.6 ACT02698.1 - 8.4e-05 22.8 1.4 8.4e-05 22.8 1.4 4.5 4 1 0 4 4 4 2 Concanavalin A-like lectin/glucanases superfamily CBM_35 PF16990.5 ACT02698.1 - 0.003 17.8 0.7 0.034 14.4 0.2 2.7 2 0 0 2 2 2 1 Carbohydrate binding module (family 35) Glyco_hydro_130 PF04041.13 ACT02698.1 - 0.0044 16.0 0.1 2.2 7.1 0.0 2.4 2 0 0 2 2 2 2 beta-1,4-mannooligosaccharide phosphorylase GntR PF00392.21 ACT02699.1 - 7.7e-20 70.3 0.1 2.9e-19 68.5 0.0 2.1 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Peripla_BP_1 PF00532.21 ACT02699.1 - 2.6e-16 59.9 0.0 4.8e-16 59.0 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT02699.1 - 2.4e-11 43.7 0.0 6.2e-11 42.4 0.0 1.6 1 1 1 2 2 2 2 Periplasmic binding protein domain Peripla_BP_3 PF13377.6 ACT02699.1 - 9.9e-09 35.7 0.0 3.5e-08 33.9 0.0 1.8 2 0 0 2 2 2 1 Periplasmic binding protein-like domain HTH_41 PF14502.6 ACT02699.1 - 0.023 14.4 0.2 0.31 10.8 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain MarR PF01047.22 ACT02699.1 - 0.023 14.6 0.0 0.067 13.1 0.0 1.8 2 0 0 2 2 2 0 MarR family HTH_Crp_2 PF13545.6 ACT02699.1 - 0.13 12.3 0.1 13 5.9 0.0 3.1 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain Glyco_hydro_25 PF01183.20 ACT02700.1 - 3.2e-50 170.8 0.7 5.3e-50 170.1 0.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 Phage_portal PF04860.12 ACT02700.1 - 0.0079 15.4 0.0 0.013 14.7 0.0 1.3 1 0 0 1 1 1 1 Phage portal protein IATP PF04568.12 ACT02700.1 - 0.097 13.1 0.2 0.29 11.6 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Cellulase PF00150.18 ACT02701.1 - 1.8e-34 119.5 16.1 3.5e-34 118.5 16.1 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) FRG1 PF06229.12 ACT02701.1 - 6.9e-06 25.9 0.2 0.013 15.2 0.0 2.3 1 1 1 2 2 2 2 FRG1-like domain Fascin PF06268.13 ACT02701.1 - 0.0096 16.1 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 1 Fascin domain SpaA PF17802.1 ACT02701.1 - 0.21 11.9 4.1 18 5.8 0.1 3.2 1 1 1 2 2 2 0 Prealbumin-like fold domain DUF2737 PF10930.8 ACT02701.1 - 0.86 9.2 5.1 4.1 7.0 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2737) AP_endonuc_2 PF01261.24 ACT02702.1 - 1.4e-16 60.6 0.0 2.9e-16 59.6 0.0 1.5 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel DUF5514 PF17633.2 ACT02702.1 - 0.063 13.5 0.1 0.13 12.5 0.1 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5514) GFO_IDH_MocA_C PF02894.17 ACT02703.1 - 9.7e-14 51.4 0.2 2.3e-13 50.2 0.2 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.22 ACT02703.1 - 1.5e-13 51.6 0.0 2.8e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ACT02703.1 - 0.0032 18.1 0.0 0.0055 17.4 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain BPD_transp_1 PF00528.22 ACT02704.1 - 8.8e-12 45.1 29.2 1.5e-10 41.1 29.2 2.3 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02705.1 - 1.2e-15 57.7 12.0 1.2e-15 57.7 12.0 1.7 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF3502 PF12010.8 ACT02706.1 - 5.8e-45 153.1 1.7 8.8e-45 152.5 0.6 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACT02706.1 - 3.1e-19 70.1 3.2 3.1e-19 70.1 3.2 1.7 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein Baculo_LEF-3 PF05847.11 ACT02706.1 - 0.023 13.9 0.1 0.044 13.0 0.1 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus late expression factor 3 (LEF-3) EF1_GNE PF00736.19 ACT02706.1 - 0.061 13.5 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 EF-1 guanine nucleotide exchange domain YppF PF14178.6 ACT02706.1 - 0.095 12.6 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 YppF-like protein Response_reg PF00072.24 ACT02707.1 - 5.5e-22 78.1 0.1 1.1e-21 77.1 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02707.1 - 2.6e-19 69.2 0.0 5.6e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02707.1 - 2.5e-13 49.7 0.0 4.2e-06 26.7 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family UPF0122 PF04297.14 ACT02707.1 - 0.0087 16.3 0.2 0.029 14.6 0.2 1.8 1 0 0 1 1 1 1 Putative helix-turn-helix protein, YlxM / p13 like HTH_3 PF01381.22 ACT02707.1 - 0.047 13.8 0.0 0.2 11.8 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix His_kinase PF06580.13 ACT02708.1 - 4.8e-20 71.7 2.1 4.8e-20 71.7 2.1 2.5 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACT02708.1 - 9e-08 32.6 0.0 2.2e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT02708.1 - 8.8e-07 29.2 0.3 2.3e-06 27.9 0.3 1.8 1 0 0 1 1 1 1 HAMP domain dCache_1 PF02743.18 ACT02708.1 - 0.064 13.0 4.4 0.019 14.8 1.5 1.6 2 0 0 2 2 2 0 Cache domain MFS_2 PF13347.6 ACT02709.1 - 1.9e-88 296.9 34.1 2.2e-88 296.7 34.1 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 ACT02709.1 - 5.4e-17 61.8 64.2 2.7e-09 36.4 21.2 2.9 1 1 2 3 3 3 3 Major Facilitator Superfamily Glyco_hydro_2_C PF02836.17 ACT02710.1 - 2.3e-30 105.8 2.2 6.5e-30 104.3 2.2 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 ACT02710.1 - 1.6e-21 77.0 4.9 2.3e-21 76.5 1.3 2.6 2 1 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 ACT02710.1 - 3.7e-12 46.9 0.0 9.2e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 DUF4982 PF16355.5 ACT02710.1 - 7.3e-07 29.0 0.0 2.6e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4982) BetaGal_dom4_5 PF13364.6 ACT02710.1 - 8.3e-05 23.1 0.3 0.00058 20.4 0.1 2.4 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain HTH_18 PF12833.7 ACT02711.1 - 1.5e-20 73.2 0.0 4e-20 71.9 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02711.1 - 1e-19 70.1 0.1 3.1e-10 39.9 0.0 3.2 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family LysR_substrate PF03466.20 ACT02712.1 - 2e-37 128.6 0.0 3e-37 128.0 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT02712.1 - 9.9e-22 76.7 0.4 2.3e-21 75.5 0.1 1.8 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 ACT02712.1 - 0.04 13.7 0.0 0.088 12.6 0.0 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_5 PF01022.20 ACT02712.1 - 0.055 13.3 0.4 0.12 12.2 0.1 1.7 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Xan_ur_permease PF00860.20 ACT02713.1 - 3e-54 184.2 38.9 4.2e-54 183.7 38.9 1.2 1 0 0 1 1 1 1 Permease family SR-25 PF10500.9 ACT02714.1 - 0.003 17.2 9.5 0.0036 17.0 9.5 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Nop14 PF04147.12 ACT02714.1 - 0.058 11.6 4.2 0.067 11.4 4.2 1.0 1 0 0 1 1 1 0 Nop14-like family Apt1 PF10351.9 ACT02714.1 - 0.075 11.9 4.8 0.08 11.8 4.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Raftlin PF15250.6 ACT02714.1 - 0.08 11.7 2.8 0.089 11.5 2.8 1.0 1 0 0 1 1 1 0 Raftlin Menin PF05053.13 ACT02714.1 - 0.084 11.2 6.4 0.085 11.2 6.4 1.0 1 0 0 1 1 1 0 Menin CDC45 PF02724.14 ACT02714.1 - 0.095 11.0 1.9 0.1 10.9 1.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ACT02714.1 - 0.1 11.8 1.6 0.12 11.6 1.6 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 ACT02714.1 - 0.12 10.9 8.0 0.13 10.8 8.0 1.0 1 0 0 1 1 1 0 Macoilin family Rod_cone_degen PF15201.6 ACT02714.1 - 0.13 12.4 0.1 0.29 11.3 0.1 1.5 1 0 0 1 1 1 0 Progressive rod-cone degeneration Vfa1 PF08432.10 ACT02714.1 - 0.32 11.3 5.6 0.4 11.0 5.6 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NST1 PF13945.6 ACT02714.1 - 0.6 10.2 9.9 0.76 9.8 9.9 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator NPR3 PF03666.13 ACT02714.1 - 0.63 8.8 4.8 0.65 8.7 4.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4614 PF15391.6 ACT02714.1 - 1 9.3 7.5 1.3 9.0 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) BPS1 PF05633.11 ACT02714.1 - 1.7 7.6 3.1 2.1 7.3 3.1 1.1 1 0 0 1 1 1 0 Protein BYPASS1-related Coilin_N PF15862.5 ACT02714.1 - 2.6 7.8 6.5 3.2 7.6 6.5 1.2 1 0 0 1 1 1 0 Coilin N-terminus CCDC106 PF15794.5 ACT02714.1 - 5.2 6.7 10.0 6.3 6.4 10.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 IDEAL PF08858.10 ACT02715.1 - 2.8e-06 27.0 0.6 4.2e-06 26.4 0.6 1.3 1 0 0 1 1 1 1 IDEAL domain SspH PF08141.12 ACT02715.1 - 0.025 14.7 0.3 0.083 13.0 0.1 1.8 2 0 0 2 2 2 0 Small acid-soluble spore protein H family TPP_enzyme_N PF02776.18 ACT02716.1 - 5e-60 202.0 0.3 2.9e-58 196.3 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 ACT02716.1 - 2.1e-50 170.5 1.0 1.6e-48 164.3 0.1 3.4 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ACT02716.1 - 6.7e-44 149.0 0.1 1.2e-43 148.1 0.1 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 ACT02716.1 - 0.003 17.3 0.3 0.0063 16.3 0.3 1.6 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Glyco_transf_4 PF13439.6 ACT02716.1 - 0.021 14.8 0.0 0.071 13.1 0.0 1.8 2 0 0 2 2 2 0 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACT02716.1 - 0.023 15.2 0.0 0.052 14.0 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain CO_dh PF02552.16 ACT02716.1 - 0.083 12.7 0.0 0.23 11.2 0.0 1.7 2 0 0 2 2 2 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit DUF2238 PF09997.9 ACT02717.1 - 1e-47 161.5 7.2 1e-47 161.5 7.2 1.6 2 0 0 2 2 2 1 Predicted membrane protein (DUF2238) PrgI PF12666.7 ACT02717.1 - 0.047 14.4 10.1 0.046 14.4 2.1 3.2 2 1 1 3 3 3 0 PrgI family protein DUF4131 PF13567.6 ACT02717.1 - 0.19 11.4 4.4 0.57 9.8 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) DUF1097 PF06496.11 ACT02717.1 - 3.7 7.6 16.4 4.2 7.5 0.1 3.8 1 1 2 4 4 4 0 Protein of unknown function (DUF1097) DUF4231 PF14015.6 ACT02717.1 - 6.1 7.4 8.0 34 5.0 3.6 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4231) F5_F8_type_C PF00754.25 ACT02718.1 - 4.9e-16 59.0 1.8 1.2e-15 57.8 0.1 2.4 3 0 0 3 3 3 1 F5/8 type C domain Pectate_lyase_3 PF12708.7 ACT02718.1 - 4e-13 49.7 1.3 4e-13 49.7 1.3 3.6 1 1 1 2 2 2 1 Pectate lyase superfamily protein Big_2 PF02368.18 ACT02718.1 - 0.00033 20.5 1.1 0.0013 18.6 1.1 2.0 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 2) AP_endonuc_2 PF01261.24 ACT02719.1 - 0.00016 21.2 0.0 0.00092 18.7 0.0 2.0 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel Pro_dh PF01619.18 ACT02720.1 - 2.1e-18 66.9 0.2 8.4e-18 64.9 0.2 1.9 1 1 0 1 1 1 1 Proline dehydrogenase HTH_18 PF12833.7 ACT02721.1 - 3.4e-20 72.1 0.3 3.4e-20 72.1 0.3 2.1 3 0 0 3 3 3 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT02721.1 - 2.1e-14 53.6 0.1 3.8e-14 52.7 0.1 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_AraC PF00165.23 ACT02721.1 - 3.1e-12 46.2 2.9 4.2e-08 33.1 0.0 3.0 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT02721.1 - 0.0059 16.3 0.1 0.011 15.5 0.1 1.3 1 0 0 1 1 1 1 Cupin domain SLH PF00395.20 ACT02722.1 - 5.7e-30 103.1 4.3 2.7e-10 40.1 0.2 4.2 3 0 0 3 3 3 3 S-layer homology domain fn3 PF00041.21 ACT02722.1 - 1.9e-17 63.3 17.8 3.6e-07 30.4 0.2 5.0 4 0 0 4 4 4 4 Fibronectin type III domain Glyco_hydro_43 PF04616.14 ACT02722.1 - 2.1e-15 56.8 5.3 1.4e-14 54.1 5.3 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 DUF4992 PF16383.5 ACT02722.1 - 0.00014 21.5 8.7 0.14 11.7 0.8 4.6 3 1 2 5 5 5 2 Domain of unknown function Malectin PF11721.8 ACT02722.1 - 0.01 15.9 0.0 0.049 13.7 0.0 2.1 1 1 0 1 1 1 0 Malectin domain Big_4 PF07532.11 ACT02722.1 - 0.014 15.1 0.8 0.014 15.1 0.8 3.9 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 4) Pur_ac_phosph_N PF16656.5 ACT02722.1 - 0.53 10.9 45.4 0.59 10.7 1.7 6.6 6 1 0 6 6 6 0 Purple acid Phosphatase, N-terminal domain Lipase_GDSL_2 PF13472.6 ACT02723.1 - 7.8e-16 59.0 0.0 1.1e-15 58.5 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ACT02723.1 - 1.5e-06 28.3 0.0 1.9e-06 28.0 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase VCBS PF13517.6 ACT02724.1 - 2.1e-13 50.6 6.7 8.7e-07 29.4 0.2 4.6 3 1 1 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ACT02724.1 - 2.6e-11 43.4 13.5 0.0019 18.3 0.3 4.5 4 0 0 4 4 4 4 FG-GAP repeat TcdB_toxin_midN PF12256.8 ACT02724.1 - 0.0001 21.7 0.2 0.49 9.7 0.0 3.7 3 0 0 3 3 3 2 Insecticide toxin TcdB middle/N-terminal region Itfg2 PF15907.5 ACT02724.1 - 0.0005 19.2 3.1 8.4 5.3 0.1 4.0 3 1 1 4 4 4 3 Integrin-alpha FG-GAP repeat-containing protein 2 Dockerin_1 PF00404.18 ACT02724.1 - 0.041 14.1 3.7 54 4.1 0.0 4.3 4 0 0 4 4 4 0 Dockerin type I domain BBS1 PF14779.6 ACT02724.1 - 0.059 12.8 0.0 2 7.8 0.0 2.7 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 1 EF-hand_1 PF00036.32 ACT02724.1 - 1.1 9.0 6.1 32 4.4 0.0 4.3 4 0 0 4 4 4 0 EF hand Polysacc_deac_1 PF01522.21 ACT02725.1 - 2e-18 66.5 0.0 2.9e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ACT02725.1 - 8.6e-05 21.9 0.0 0.00011 21.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 DUF1961 PF09224.11 ACT02726.1 - 1.4e-107 358.0 0.0 1.5e-107 357.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1961) HTH_18 PF12833.7 ACT02728.1 - 5.8e-20 71.3 0.0 5e-19 68.3 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02728.1 - 2.3e-15 56.2 0.1 9.1e-10 38.4 0.0 2.9 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family dCache_1 PF02743.18 ACT02728.1 - 4.7e-10 39.7 0.9 9.7e-10 38.6 0.9 1.5 1 0 0 1 1 1 1 Cache domain GGDEF_2 PF17853.1 ACT02728.1 - 4.4e-05 23.7 0.0 0.00018 21.8 0.0 2.0 2 0 0 2 2 2 1 GGDEF-like domain Rrf2 PF02082.20 ACT02728.1 - 0.0099 16.2 0.0 4.7 7.6 0.0 2.7 1 1 0 2 2 2 1 Transcriptional regulator Osmo_CC PF08946.10 ACT02728.1 - 0.0099 16.1 0.7 0.0099 16.1 0.7 3.4 3 0 0 3 3 3 1 Osmosensory transporter coiled coil Myc_target_1 PF15179.6 ACT02728.1 - 0.022 14.6 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 Myc target protein 1 FtsX PF02687.21 ACT02728.1 - 0.027 15.0 2.7 3.3 8.2 1.5 2.4 2 0 0 2 2 2 0 FtsX-like permease family LapA_dom PF06305.11 ACT02728.1 - 0.2 11.5 3.2 6.6 6.6 0.1 2.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain SBP_bac_1 PF01547.25 ACT02729.1 - 1.9e-18 67.5 14.1 3.6e-18 66.6 14.1 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT02729.1 - 0.01 16.5 0.1 0.037 14.7 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3502) BPD_transp_1 PF00528.22 ACT02730.1 - 1.5e-21 77.0 19.6 3.5e-20 72.5 19.5 2.1 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02731.1 - 9.3e-17 61.4 13.6 9.3e-17 61.4 13.6 1.6 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component CBM_X2 PF03442.14 ACT02733.1 - 5e-66 218.8 4.2 4.2e-22 78.1 0.0 3.9 3 0 0 3 3 3 3 Carbohydrate binding domain X2 SLH PF00395.20 ACT02733.1 - 5.5e-35 119.1 12.9 4.3e-15 55.5 0.4 4.8 4 0 0 4 4 4 3 S-layer homology domain Melibiase_2 PF16499.5 ACT02733.1 - 4.4e-28 98.3 6.9 7e-15 54.9 4.4 2.3 2 0 0 2 2 2 2 Alpha galactosidase A CE2_N PF17996.1 ACT02733.1 - 1.4e-16 60.4 0.2 0.00036 20.5 0.0 4.0 3 0 0 3 3 3 3 Carbohydrate esterase 2 N-terminal Melibiase_C PF17801.1 ACT02733.1 - 5.4e-13 48.8 0.0 1.9e-12 47.0 0.0 2.1 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ACT02733.1 - 0.00023 20.3 0.4 0.00037 19.5 0.4 1.2 1 0 0 1 1 1 1 Melibiase Big_7 PF17957.1 ACT02733.1 - 0.0061 17.3 12.4 2.6 8.9 0.6 5.3 4 1 0 4 4 4 3 Bacterial Ig domain CBM_6 PF03422.15 ACT02733.1 - 9.1 6.6 17.6 0.23 11.8 0.2 5.7 5 2 1 6 6 6 0 Carbohydrate binding module (family 6) Laminin_G_3 PF13385.6 ACT02734.1 - 6e-30 104.4 4.9 1.8e-29 102.8 4.9 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily GH43_C PF16369.5 ACT02734.1 - 6e-29 100.7 0.8 2.3e-28 98.8 0.8 2.1 1 0 0 1 1 1 1 C-terminal lipocalin-like domain Glyco_hydro_43 PF04616.14 ACT02734.1 - 6e-25 88.1 12.9 8.9e-11 41.6 0.2 4.0 3 1 0 3 3 3 3 Glycosyl hydrolases family 43 DUF3761 PF12587.8 ACT02734.1 - 0.14 12.6 0.0 0.55 10.7 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) BPD_transp_1 PF00528.22 ACT02735.1 - 6.3e-14 52.1 10.7 6.3e-14 52.1 10.7 1.9 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02736.1 - 4.4e-18 65.7 12.6 4.4e-18 65.7 12.6 1.9 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Epiglycanin_C PF14654.6 ACT02736.1 - 0.021 14.9 1.9 0.023 14.8 0.3 1.9 2 0 0 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region SBP_bac_1 PF01547.25 ACT02737.1 - 1.3e-16 61.5 13.8 1.3e-16 61.5 13.8 1.8 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein DUF2442 PF10387.9 ACT02737.1 - 0.051 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2442) HTH_18 PF12833.7 ACT02739.1 - 1.3e-20 73.4 0.1 3e-20 72.3 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02739.1 - 2.5e-16 59.3 0.1 5.3e-08 32.8 0.1 2.7 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family dCache_1 PF02743.18 ACT02739.1 - 1.2e-13 51.4 2.0 2.2e-13 50.6 2.0 1.4 1 0 0 1 1 1 1 Cache domain GGDEF_2 PF17853.1 ACT02739.1 - 0.00073 19.8 0.0 0.0015 18.7 0.0 1.6 1 0 0 1 1 1 1 GGDEF-like domain Jagunal PF07086.12 ACT02739.1 - 0.0046 17.1 1.2 2.1 8.4 0.2 2.4 2 0 0 2 2 2 2 Jagunal, ER re-organisation during oogenesis TIC20 PF16166.5 ACT02739.1 - 0.58 9.9 3.0 11 5.7 0.0 3.1 3 0 0 3 3 3 0 Chloroplast import apparatus Tic20-like Spore_permease PF03845.13 ACT02740.1 - 2.1e-56 191.1 36.1 3.2e-56 190.5 36.1 1.3 1 0 0 1 1 1 1 Spore germination protein Na_Ala_symp PF01235.17 ACT02740.1 - 0.00047 19.6 2.9 0.00047 19.6 2.9 2.8 2 1 1 3 3 3 1 Sodium:alanine symporter family Spore_GerAC PF05504.11 ACT02741.1 - 4e-35 121.4 0.9 5.6e-35 121.0 0.9 1.2 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal DrsE PF02635.15 ACT02741.1 - 0.044 14.2 0.0 0.089 13.2 0.0 1.4 1 0 0 1 1 1 0 DsrE/DsrF-like family GerA PF03323.13 ACT02742.1 - 4.2e-194 645.4 4.4 4.8e-194 645.2 4.4 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein B3R PF17057.5 ACT02742.1 - 0.11 12.7 0.0 0.33 11.2 0.0 1.7 1 0 0 1 1 1 0 Poxviridae B3 protein TetR_N PF00440.23 ACT02743.1 - 1.6e-16 59.8 0.1 2.5e-16 59.2 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_33 PF13305.6 ACT02743.1 - 1.6e-05 25.6 0.0 2.3e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 ACT02743.1 - 0.0028 17.8 0.0 0.0057 16.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase HTH_38 PF13936.6 ACT02743.1 - 0.0086 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain LacI PF00356.21 ACT02743.1 - 0.011 15.5 0.0 0.16 11.8 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family HTH_23 PF13384.6 ACT02743.1 - 0.026 14.3 0.0 0.056 13.3 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain CENP-B_N PF04218.13 ACT02743.1 - 0.044 13.4 0.1 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain HTH_50 PF18024.1 ACT02743.1 - 0.069 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain AbiEi_4 PF13338.6 ACT02743.1 - 0.094 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin Fanconi_A PF03511.14 ACT02743.1 - 0.13 12.2 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Fanconi anaemia group A protein HTH_36 PF13730.6 ACT02743.1 - 0.13 12.2 0.1 0.98 9.4 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain YdjM PF04307.14 ACT02744.1 - 0.0003 20.1 8.2 0.00056 19.3 8.2 1.6 1 1 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase MFS_1 PF07690.16 ACT02745.1 - 2.6e-53 181.2 51.4 3.5e-53 180.8 49.5 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TetR_C_8 PF14278.6 ACT02746.1 - 1.5e-17 63.5 0.3 9e-17 61.1 0.0 2.0 2 1 0 2 2 2 1 Transcriptional regulator C-terminal region TetR_N PF00440.23 ACT02746.1 - 0.0006 19.5 0.0 0.0015 18.3 0.0 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family Put_DNA-bind_N PF06971.13 ACT02746.1 - 0.2 11.7 1.5 1.1 9.4 0.1 2.8 2 1 1 3 3 3 0 Putative DNA-binding protein N-terminus Peripla_BP_3 PF13377.6 ACT02747.1 - 9.6e-42 143.1 0.0 1.7e-41 142.3 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT02747.1 - 7e-27 94.6 0.0 9.3e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT02747.1 - 6.4e-20 71.8 0.0 9.8e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein domain LacI PF00356.21 ACT02747.1 - 4.2e-17 61.7 0.6 4.2e-17 61.7 0.6 2.1 2 1 0 2 2 2 1 Bacterial regulatory proteins, lacI family IF2_N PF04760.15 ACT02747.1 - 0.00037 20.3 0.3 0.029 14.2 0.1 2.6 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region HTH_7 PF02796.15 ACT02747.1 - 0.016 15.3 0.2 0.045 13.8 0.2 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Metallophos_2 PF12850.7 ACT02747.1 - 0.018 15.2 0.1 0.073 13.3 0.0 1.8 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain TrmB PF01978.19 ACT02747.1 - 0.025 14.5 1.7 0.55 10.2 0.2 2.7 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_31 PF13560.6 ACT02747.1 - 0.052 13.9 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_26 PF13443.6 ACT02747.1 - 0.061 13.8 0.0 0.29 11.6 0.0 2.0 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain PIN_9 PF18477.1 ACT02747.1 - 0.068 13.5 0.1 0.18 12.1 0.1 1.7 1 0 0 1 1 1 0 PIN like domain MarR_2 PF12802.7 ACT02747.1 - 0.078 12.9 0.3 0.74 9.7 0.1 2.6 3 0 0 3 3 3 0 MarR family TetR_N PF00440.23 ACT02747.1 - 0.089 12.6 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_5 PF01022.20 ACT02747.1 - 0.091 12.7 1.2 0.48 10.3 0.0 2.7 4 0 0 4 4 4 0 Bacterial regulatory protein, arsR family Sigma54_DBD PF04552.13 ACT02747.1 - 0.092 12.4 2.0 3.1 7.5 0.1 3.0 3 0 0 3 3 3 0 Sigma-54, DNA binding domain Trp_repressor PF01371.19 ACT02747.1 - 0.097 12.8 0.6 0.2 11.8 0.1 1.8 2 0 0 2 2 1 0 Trp repressor protein Glyco_hydro_35 PF01301.19 ACT02748.1 - 9.8e-94 314.5 1.5 1.4e-93 314.0 1.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 ACT02748.1 - 2.7e-10 40.1 0.3 7.1e-10 38.8 0.3 1.6 1 1 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 ACT02748.1 - 6.8e-07 29.9 0.1 0.0038 17.8 0.0 2.9 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain Glyco_hydr_30_2 PF14587.6 ACT02749.1 - 4.2e-35 122.0 1.0 9.5e-32 111.0 0.3 2.1 1 1 1 2 2 2 2 O-Glycosyl hydrolase family 30 Glyco_hydro_59 PF02057.15 ACT02749.1 - 1.2e-11 44.4 4.9 5.5e-11 42.2 4.9 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 59 AP_endonuc_2 PF01261.24 ACT02749.1 - 2.9e-05 23.6 0.0 0.016 14.7 0.0 2.6 2 1 0 2 2 2 2 Xylose isomerase-like TIM barrel Glyco_hydro_30 PF02055.16 ACT02749.1 - 3.1e-05 23.1 2.6 0.00018 20.6 1.8 2.3 2 1 0 2 2 2 1 Glycosyl hydrolase family 30 TIM-barrel domain F5_F8_type_C PF00754.25 ACT02750.1 - 5.2e-24 84.8 23.9 5.4e-07 29.8 1.2 6.1 7 1 0 7 7 7 4 F5/8 type C domain ChitinaseA_N PF08329.10 ACT02750.1 - 1.7e-09 37.4 3.8 0.0003 20.4 0.2 3.7 3 1 1 4 4 4 2 Chitinase A, N-terminal domain FIVAR PF07554.13 ACT02750.1 - 8.7e-05 23.2 2.3 8.7e-05 23.2 2.3 3.1 3 0 0 3 3 3 1 FIVAR domain Alginate_lyase PF05426.12 ACT02750.1 - 9.6e-05 22.1 2.7 0.00021 20.9 2.7 1.5 1 0 0 1 1 1 1 Alginate lyase TcfC PF16967.5 ACT02750.1 - 0.017 14.6 0.0 0.23 11.0 0.0 2.6 2 0 0 2 2 2 0 E-set like domain DUF3244 PF11589.8 ACT02750.1 - 0.048 13.7 3.8 16 5.7 0.0 4.6 3 1 1 4 4 4 0 Domain of unknown function (DUF3244) He_PIG PF05345.12 ACT02750.1 - 0.93 9.7 9.7 0.19 11.9 0.4 4.0 3 0 0 3 3 3 0 Putative Ig domain Polbeta PF18765.1 ACT02751.1 - 7.7e-05 22.7 0.0 0.00022 21.2 0.0 1.8 1 1 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 ACT02751.1 - 0.022 15.1 0.0 0.052 13.8 0.0 1.7 1 0 0 1 1 1 0 Nucleotidyltransferase domain DUF4328 PF14219.6 ACT02752.1 - 5.4e-06 26.1 4.2 2.6e-05 23.8 0.1 2.7 2 1 1 3 3 3 1 Domain of unknown function (DUF4328) PMP1_2 PF08114.11 ACT02752.1 - 0.0015 18.2 1.1 0.0015 18.2 1.1 3.1 4 0 0 4 4 4 1 ATPase proteolipid family RDD PF06271.12 ACT02752.1 - 7.5 6.7 11.5 2.9 8.1 0.5 2.2 2 0 0 2 2 2 0 RDD family VanZ PF04892.12 ACT02754.1 - 4.2e-18 66.2 7.9 5.4e-18 65.9 7.9 1.1 1 0 0 1 1 1 1 VanZ like family DUF2809 PF10990.8 ACT02754.1 - 0.035 14.8 5.1 0.08 13.6 0.3 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF2809) DUF3502 PF12010.8 ACT02755.1 - 4.7e-22 79.0 1.3 1.3e-21 77.6 0.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACT02755.1 - 1.8e-05 24.9 6.8 4.3e-05 23.6 6.8 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein His_kinase PF06580.13 ACT02756.1 - 4.8e-24 84.5 3.6 1.3e-23 83.1 2.0 2.6 3 0 0 3 3 3 1 Histidine kinase HATPase_c PF02518.26 ACT02756.1 - 4.7e-11 43.2 0.0 1.4e-10 41.7 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACT02756.1 - 6.3e-08 32.7 4.0 6.3e-08 32.7 4.0 2.1 2 0 0 2 2 2 1 Cache domain HAMP PF00672.25 ACT02756.1 - 3.3e-06 27.4 0.0 9.1e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c_5 PF14501.6 ACT02756.1 - 0.054 13.4 0.0 0.2 11.6 0.0 2.0 1 0 0 1 1 1 0 GHKL domain Holin_BhlA PF10960.8 ACT02756.1 - 0.085 12.8 1.8 7.2 6.7 0.1 2.8 2 0 0 2 2 2 0 BhlA holin family HATPase_c_2 PF13581.6 ACT02756.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Response_reg PF00072.24 ACT02757.1 - 4.4e-24 84.8 0.0 1.3e-23 83.3 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02757.1 - 2.2e-18 66.3 0.1 1.2e-17 63.9 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02757.1 - 4e-17 61.8 0.7 2.9e-08 33.6 0.0 3.0 4 0 0 4 4 4 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT02757.1 - 1.4e-06 28.5 0.0 3.1e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 GGDEF-like domain HAD_2 PF13419.6 ACT02757.1 - 0.25 11.4 0.8 12 5.9 0.1 2.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Glyco_hydro_43 PF04616.14 ACT02758.1 - 4.8e-08 32.7 3.3 1.4e-07 31.1 2.7 1.8 1 1 1 2 2 2 2 Glycosyl hydrolases family 43 SBP_bac_8 PF13416.6 ACT02759.1 - 1.2e-07 31.9 13.3 1.2e-07 31.9 13.3 1.9 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT02759.1 - 0.0027 18.3 0.5 0.0027 18.3 0.5 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) BPD_transp_1 PF00528.22 ACT02760.1 - 2.3e-11 43.8 25.6 1.6e-10 41.0 25.6 2.3 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SH PF01445.17 ACT02760.1 - 3.3 7.8 10.1 17 5.5 0.1 3.7 2 1 1 3 3 3 0 Viral small hydrophobic protein BPD_transp_1 PF00528.22 ACT02761.1 - 1.2e-14 54.5 10.6 1.2e-14 54.5 10.6 1.8 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component MNHE PF01899.16 ACT02761.1 - 2.9 7.7 6.7 7.9 6.2 0.9 2.7 2 1 0 2 2 2 0 Na+/H+ ion antiporter subunit Glyco_hydro_88 PF07470.13 ACT02762.1 - 2.4e-23 82.8 2.4 2e-22 79.7 2.8 1.9 1 1 1 2 2 2 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 ACT02762.1 - 0.00052 19.6 0.2 0.0045 16.5 0.1 2.3 3 0 0 3 3 3 1 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_76 PF03663.14 ACT02762.1 - 0.26 10.8 7.2 4.4 6.7 0.1 3.2 2 1 0 3 3 3 0 Glycosyl hydrolase family 76 Glyco_hydro_28 PF00295.17 ACT02764.1 - 1.7e-13 50.3 1.9 3.3e-13 49.4 1.9 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 ACT02764.1 - 0.00025 20.9 17.7 0.00051 19.9 4.3 3.2 1 1 2 3 3 3 2 Right handed beta helix region Glyco_hydro_49N PF17433.2 ACT02764.1 - 0.004 16.8 0.0 0.0073 16.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 49 N-terminal Ig-like domain LBP_M PF17385.2 ACT02765.1 - 0.015 14.8 0.3 0.02 14.4 0.3 1.1 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase central domain DUF2140 PF09911.9 ACT02765.1 - 0.064 12.8 0.2 0.095 12.2 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) MIG-14_Wnt-bd PF06664.12 ACT02767.1 - 0.01 15.1 9.1 0.23 10.6 1.8 2.1 2 0 0 2 2 2 0 Wnt-binding factor required for Wnt secretion CitMHS PF03600.16 ACT02767.1 - 0.15 11.2 7.0 0.24 10.6 7.0 1.3 1 0 0 1 1 1 0 Citrate transporter SIT PF15330.6 ACT02767.1 - 0.72 10.3 9.8 2 8.9 0.1 3.2 2 1 1 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT UPF0182 PF03699.13 ACT02767.1 - 3.7 5.6 9.9 0.26 9.4 1.5 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) DUF423 PF04241.15 ACT02767.1 - 4 7.7 8.9 0.42 10.8 2.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF423) Pox_I5 PF04713.12 ACT02767.1 - 5.8 7.0 10.3 15 5.7 0.2 3.7 4 0 0 4 4 4 0 Poxvirus protein I5 tRNA-synt_1c PF00749.21 ACT02769.1 - 7.2e-98 327.3 0.0 9.2e-98 327.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ACT02769.1 - 1.4e-50 171.5 0.0 2.3e-50 170.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain Glyco_hydro_43 PF04616.14 ACT02770.1 - 3.6e-09 36.3 3.1 5.8e-09 35.7 2.7 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 CdiI_N PF18228.1 ACT02770.1 - 0.13 12.1 0.5 0.38 10.6 0.3 1.9 2 0 0 2 2 2 0 CdiI N-terminal domain Pyrid_ox_like PF16242.5 ACT02771.1 - 1.9e-47 160.6 1.1 2.4e-47 160.2 1.1 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 ACT02771.1 - 1e-13 51.2 0.0 1.6e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 ACT02771.1 - 0.011 15.8 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.12 ACT02771.1 - 0.075 12.7 0.0 0.29 10.8 0.0 1.8 1 1 1 2 2 2 0 Putative FMN-binding domain Phtf-FEM1B_bdg PF12129.8 ACT02772.1 - 0.018 14.9 1.2 0.018 14.9 1.2 1.6 1 1 1 2 2 2 0 Male germ-cell putative homeodomain transcription factor DHHC PF01529.20 ACT02772.1 - 7.7 6.6 7.8 1.3 9.1 3.9 1.7 1 1 1 2 2 2 0 DHHC palmitoyltransferase 3-dmu-9_3-mt PF06983.13 ACT02773.1 - 9.7e-09 35.8 0.0 1.1e-08 35.6 0.0 1.0 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase Glyoxalase PF00903.25 ACT02773.1 - 1.4e-05 25.2 0.0 4.6e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily SepF PF04472.12 ACT02773.1 - 0.099 12.9 0.0 0.31 11.3 0.0 1.8 2 0 0 2 2 2 0 Cell division protein SepF PurS PF02700.14 ACT02773.1 - 0.18 12.0 0.0 0.33 11.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylformylglycinamidine (FGAM) synthase Rhodanese PF00581.20 ACT02774.1 - 2.9e-11 43.8 0.0 2.1e-10 41.1 0.0 2.4 2 1 0 2 2 2 1 Rhodanese-like domain AAA_23 PF13476.6 ACT02774.1 - 0.00032 21.3 0.4 0.0052 17.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ACT02774.1 - 0.00048 20.7 0.1 0.0017 18.9 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 ACT02774.1 - 0.00053 20.3 0.0 0.0015 18.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT02774.1 - 0.0017 18.8 0.2 0.0033 17.8 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 ACT02774.1 - 0.0037 17.0 0.1 0.024 14.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ACT02774.1 - 0.0076 16.5 0.3 0.02 15.2 0.3 1.9 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ACT02774.1 - 0.0097 15.2 0.0 0.024 13.9 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin RsgA_GTPase PF03193.16 ACT02774.1 - 0.021 14.7 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 ACT02774.1 - 0.034 14.2 0.0 0.083 12.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CoaE PF01121.20 ACT02774.1 - 0.041 13.6 0.1 0.23 11.1 0.0 2.1 2 0 0 2 2 2 0 Dephospho-CoA kinase AAA_33 PF13671.6 ACT02774.1 - 0.058 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 ACT02774.1 - 0.076 12.1 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Sigma54_activat PF00158.26 ACT02774.1 - 0.1 12.3 0.0 0.6 9.8 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 ACT02774.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ACT02774.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 ACT02774.1 - 0.12 12.9 0.1 0.27 11.7 0.1 1.6 1 1 0 1 1 1 0 ABC transporter AIRS_C PF02769.22 ACT02775.1 - 5.2e-32 111.1 0.6 7.7e-32 110.6 0.6 1.2 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 ACT02775.1 - 3.8e-21 75.5 0.2 7.9e-21 74.5 0.2 1.6 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain FliG_N PF14842.6 ACT02775.1 - 0.013 16.0 0.0 0.4 11.3 0.0 2.6 3 0 0 3 3 3 0 FliG N-terminal domain Acetyltransf_3 PF13302.7 ACT02776.1 - 1.3e-31 110.2 0.0 1.5e-31 109.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT02776.1 - 1.2e-06 28.7 0.1 1.6e-06 28.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 ACT02776.1 - 5e-05 23.5 0.0 5.3e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ACT02776.1 - 0.0029 17.3 0.0 0.0048 16.6 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Sulfatase PF00884.23 ACT02777.1 - 2.7e-34 119.0 0.4 3.4e-34 118.6 0.4 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACT02777.1 - 3.2e-05 23.7 4.7 0.00041 20.0 4.7 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 ACT02777.1 - 0.018 13.7 0.0 0.021 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Sulfatase PF00884.23 ACT02778.1 - 2.4e-78 263.7 0.0 2.8e-78 263.4 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACT02778.1 - 1.8e-12 47.6 0.4 5.5e-12 45.9 0.4 1.6 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4994 PF16385.5 ACT02778.1 - 0.0003 20.7 0.1 0.0013 18.6 0.1 1.9 1 1 0 1 1 1 1 Domain of unknown function Sulfatase_C PF14707.6 ACT02778.1 - 0.013 16.3 0.3 0.089 13.5 0.3 2.1 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF1501 PF07394.12 ACT02778.1 - 0.03 13.4 0.0 0.051 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DUF229 PF02995.17 ACT02778.1 - 0.03 12.9 0.0 0.22 10.1 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF229) HU-CCDC81_bac_2 PF18175.1 ACT02778.1 - 0.055 13.3 0.3 1.2 9.0 0.2 2.8 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 ABC_tran PF00005.27 ACT02779.1 - 7e-32 110.8 0.0 1.2e-31 110.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 ACT02779.1 - 9.8e-15 54.8 0.4 1.8e-14 54.0 0.4 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_22 PF13401.6 ACT02779.1 - 2.5e-06 27.8 0.1 2.4e-05 24.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT02779.1 - 1.9e-05 25.1 0.0 3e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT02779.1 - 0.00056 19.6 0.0 0.001 18.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ACT02779.1 - 0.0011 18.8 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ACT02779.1 - 0.0011 18.4 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI SMC_N PF02463.19 ACT02779.1 - 0.0019 17.7 0.2 0.018 14.5 0.2 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ACT02779.1 - 0.0034 17.3 0.1 0.0056 16.6 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase PRK PF00485.18 ACT02779.1 - 0.0079 16.0 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_21 PF13304.6 ACT02779.1 - 0.0092 15.8 0.2 3.8 7.2 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 ACT02779.1 - 0.0093 15.7 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 ACT02779.1 - 0.016 15.7 0.0 0.03 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 ACT02779.1 - 0.021 15.0 0.1 0.04 14.0 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain NACHT PF05729.12 ACT02779.1 - 0.023 14.6 0.0 0.42 10.5 0.0 2.3 2 0 0 2 2 2 0 NACHT domain APS_kinase PF01583.20 ACT02779.1 - 0.034 14.1 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase Sigma54_activat PF00158.26 ACT02779.1 - 0.039 13.7 0.0 0.063 13.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_23 PF13476.6 ACT02779.1 - 0.046 14.2 0.0 0.067 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF3987 PF13148.6 ACT02779.1 - 0.053 12.5 0.0 0.15 11.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) ATP-synt_ab PF00006.25 ACT02779.1 - 0.053 13.2 0.0 0.06 13.0 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Zeta_toxin PF06414.12 ACT02779.1 - 0.066 12.5 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_10 PF12846.7 ACT02779.1 - 0.068 12.1 0.0 0.19 10.6 0.0 1.7 2 0 0 2 2 2 0 AAA-like domain MMR_HSR1 PF01926.23 ACT02779.1 - 0.092 12.8 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_13 PF13166.6 ACT02779.1 - 0.095 11.3 0.0 5.3 5.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ACT02779.1 - 0.11 12.1 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ACT02779.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ACT02779.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ACT02779.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_15 PF13175.6 ACT02779.1 - 0.18 11.5 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ACT02780.1 - 2e-25 89.9 0.0 2.9e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 ACT02780.1 - 1.3e-19 70.5 0.2 2.8e-19 69.4 0.2 1.6 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 ACT02780.1 - 7.3e-05 22.7 0.4 0.00018 21.4 0.0 1.7 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT02780.1 - 0.0032 16.9 0.0 0.0064 16.0 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_33 PF13671.6 ACT02780.1 - 0.018 15.2 0.0 0.028 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 ACT02780.1 - 0.061 12.1 0.0 0.22 10.3 0.0 1.7 1 1 0 1 1 1 0 Predicted ATPase of the ABC class PRK PF00485.18 ACT02780.1 - 0.11 12.2 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family BPD_transp_1 PF00528.22 ACT02781.1 - 1.5e-23 83.5 14.4 1.5e-23 83.5 14.4 1.8 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 ACT02781.1 - 0.00044 20.2 0.3 0.00044 20.2 0.3 3.0 3 0 0 3 3 3 1 N-terminal TM domain of oligopeptide transport permease C BPD_transp_1 PF00528.22 ACT02782.1 - 3.5e-36 124.7 15.8 3.5e-36 124.7 15.8 1.5 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component PyrBI_leader PF08052.11 ACT02782.1 - 0.081 12.9 0.7 0.56 10.2 0.1 2.7 3 0 0 3 3 3 0 PyrBI operon leader peptide SBP_bac_5 PF00496.22 ACT02783.1 - 1.8e-70 237.8 3.8 2.6e-70 237.3 3.8 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle HTH_18 PF12833.7 ACT02784.1 - 6.6e-20 71.2 0.0 1.9e-19 69.7 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02784.1 - 4.1e-19 68.2 0.0 3.6e-10 39.7 0.0 3.0 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family dCache_1 PF02743.18 ACT02784.1 - 4.5e-10 39.7 1.5 1.1e-09 38.5 1.5 1.7 1 0 0 1 1 1 1 Cache domain GGDEF_2 PF17853.1 ACT02784.1 - 1.5e-07 31.7 0.0 6.6e-07 29.6 0.0 2.1 1 0 0 1 1 1 1 GGDEF-like domain MarR_2 PF12802.7 ACT02784.1 - 0.0088 15.9 0.0 0.029 14.3 0.0 1.8 2 0 0 2 2 2 1 MarR family Prominin PF05478.11 ACT02784.1 - 0.071 11.1 0.7 0.14 10.1 0.7 1.4 1 0 0 1 1 1 0 Prominin TarH PF02203.15 ACT02784.1 - 0.15 12.0 0.1 0.15 12.0 0.1 1.8 2 0 0 2 2 2 0 Tar ligand binding domain homologue IMS PF00817.20 ACT02784.1 - 0.18 11.8 0.0 0.7 9.9 0.0 1.9 2 0 0 2 2 2 0 impB/mucB/samB family Ac76 PF05814.11 ACT02784.1 - 0.51 10.4 10.0 0.05 13.6 4.0 2.2 2 0 0 2 2 2 0 Orf76 (Ac76) Glyco_hydr_30_2 PF14587.6 ACT02785.1 - 1e-109 367.5 4.2 1.6e-109 366.9 4.2 1.3 1 0 0 1 1 1 1 O-Glycosyl hydrolase family 30 fn3 PF00041.21 ACT02785.1 - 1.6e-17 63.6 3.7 8.1e-05 22.9 0.0 4.6 4 0 0 4 4 4 3 Fibronectin type III domain Glyco_hydro_30C PF17189.4 ACT02785.1 - 1.1e-06 28.8 0.1 4.2e-06 26.9 0.1 2.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 ACT02785.1 - 4.1e-06 26.2 1.0 7.4e-05 22.1 0.6 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 59 DUF1080 PF06439.11 ACT02785.1 - 4.4e-05 23.7 1.7 0.00015 22.0 0.1 2.7 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1080) DUF4959 PF16323.5 ACT02785.1 - 0.0013 19.0 6.6 0.018 15.4 0.2 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF4959) Epimerase PF01370.21 ACT02786.1 - 5.9e-61 206.0 0.3 7.3e-61 205.7 0.3 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACT02786.1 - 1.4e-60 205.5 0.1 4.9e-60 203.7 0.1 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ACT02786.1 - 2.7e-25 89.0 0.1 3.7e-25 88.6 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ACT02786.1 - 2.4e-22 79.3 0.6 3.2e-22 78.9 0.6 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ACT02786.1 - 3.4e-19 69.1 1.7 4.7e-18 65.3 1.7 2.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ACT02786.1 - 2.4e-14 53.2 0.6 8e-11 41.6 0.0 2.4 2 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 ACT02786.1 - 1.3e-09 38.3 0.0 1.8e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT02786.1 - 0.014 15.0 0.4 0.029 13.9 0.4 1.6 1 1 0 1 1 1 0 NmrA-like family KR PF08659.10 ACT02786.1 - 0.027 14.4 1.7 0.25 11.2 1.7 2.2 1 1 0 1 1 1 0 KR domain adh_short PF00106.25 ACT02786.1 - 0.042 13.3 0.5 0.081 12.4 0.5 1.6 1 1 0 1 1 1 0 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 ACT02786.1 - 0.11 12.7 0.4 0.23 11.7 0.4 1.6 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Methyltransf_23 PF13489.6 ACT02787.1 - 1.5e-15 57.4 0.0 2e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT02787.1 - 3e-13 49.8 0.0 3.5e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT02787.1 - 1.4e-12 48.0 0.0 2.3e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT02787.1 - 2.3e-10 41.1 0.0 3.7e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT02787.1 - 3e-10 40.7 0.0 5.2e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ACT02787.1 - 0.0001 21.7 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 ACT02787.1 - 0.00029 19.8 0.1 0.00099 18.1 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 ACT02787.1 - 0.00042 20.3 0.0 0.37 10.7 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 ACT02787.1 - 0.017 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 ACT02787.1 - 0.019 14.5 0.0 0.029 13.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain MetW PF07021.12 ACT02787.1 - 0.042 13.4 0.0 0.061 12.9 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW BNR_2 PF13088.6 ACT02791.1 - 1.7e-09 37.4 0.3 0.00034 20.0 0.0 3.4 1 1 2 3 3 3 3 BNR repeat-like domain BNR PF02012.20 ACT02791.1 - 1.9e-08 33.1 5.8 0.82 9.9 0.0 6.0 6 0 0 6 6 6 3 BNR/Asp-box repeat Laminin_N PF00055.17 ACT02791.1 - 0.055 13.1 0.0 3.6 7.1 0.0 3.0 3 0 0 3 3 3 0 Laminin N-terminal (Domain VI) Glycos_transf_1 PF00534.20 ACT02792.1 - 3.6e-34 117.8 0.0 5.5e-34 117.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT02792.1 - 1.2e-25 90.5 0.0 2.2e-25 89.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ACT02792.1 - 1.9e-23 83.6 0.0 4.2e-23 82.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 ACT02792.1 - 5.1e-18 65.6 0.1 1.2e-17 64.5 0.1 1.7 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 ACT02792.1 - 6.2e-06 26.5 0.0 1.6e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 ACT02792.1 - 0.037 13.7 0.0 0.31 10.7 0.0 2.0 1 1 0 1 1 1 0 Starch synthase catalytic domain Glyco_trans_4_2 PF13477.6 ACT02792.1 - 0.06 13.4 0.1 0.66 10.0 0.1 2.2 1 1 0 1 1 1 0 Glycosyl transferase 4-like Glycos_transf_1 PF00534.20 ACT02793.1 - 1.3e-38 132.3 0.0 2.1e-38 131.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT02793.1 - 8e-28 97.5 0.0 1.9e-27 96.3 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACT02793.1 - 1.1e-19 71.1 0.0 1.9e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACT02793.1 - 3.9e-15 56.6 0.0 7.4e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ACT02793.1 - 2e-09 37.7 0.0 3.6e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 ACT02793.1 - 0.0041 16.8 0.1 0.17 11.5 0.1 2.4 1 1 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_2 PF13477.6 ACT02793.1 - 0.017 15.1 0.1 0.11 12.6 0.1 2.0 1 1 0 1 1 1 0 Glycosyl transferase 4-like Epimerase PF01370.21 ACT02794.1 - 1.8e-56 191.3 0.0 2.6e-56 190.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACT02794.1 - 4.1e-54 184.2 0.0 5.8e-54 183.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ACT02794.1 - 8.6e-19 67.6 0.0 2.5e-18 66.1 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ACT02794.1 - 2e-15 56.7 0.0 1.4e-11 44.1 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ACT02794.1 - 4.5e-15 55.5 0.9 4e-10 39.3 0.0 2.4 3 0 0 3 3 3 2 Male sterility protein RmlD_sub_bind PF04321.17 ACT02794.1 - 7.7e-09 35.1 0.0 1e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ACT02794.1 - 1.7e-07 31.3 0.0 2.6e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT02794.1 - 2.1e-05 24.2 0.0 3.1e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ACT02794.1 - 0.00092 18.7 0.0 0.0019 17.7 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT02794.1 - 0.0041 17.1 0.4 0.071 13.0 0.3 2.4 2 1 0 2 2 2 1 KR domain 3HCDH_N PF02737.18 ACT02794.1 - 0.02 14.8 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ACT02795.1 - 3.4e-39 134.4 0.0 8.1e-39 133.1 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 ACT02795.1 - 1.3e-29 102.2 0.0 2.3e-29 101.4 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 ACT02795.1 - 3.3e-22 78.9 0.0 1.7e-20 73.4 0.0 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_2 PF03446.15 ACT02795.1 - 1.9e-08 34.6 0.0 7.2e-08 32.7 0.0 2.0 3 0 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACT02795.1 - 2.2e-06 28.1 0.0 1.1e-05 26.0 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 ACT02795.1 - 6.6e-05 22.6 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 ACT02795.1 - 0.00059 20.1 0.8 0.0032 17.7 0.0 2.6 4 0 0 4 4 4 1 TrkA-N domain NAD_Gly3P_dh_N PF01210.23 ACT02795.1 - 0.0011 18.9 0.0 0.0035 17.3 0.0 1.9 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 ACT02795.1 - 0.0035 17.3 0.0 0.02 14.8 0.0 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ACT02795.1 - 0.0088 15.4 0.5 0.34 10.3 0.2 3.0 3 1 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ACT02795.1 - 0.025 15.0 0.0 0.99 9.9 0.0 2.8 3 1 0 3 3 3 0 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 ACT02795.1 - 0.05 12.9 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PDH PF02153.17 ACT02795.1 - 0.12 11.3 0.0 0.29 10.1 0.0 1.7 1 0 0 1 1 1 0 Prephenate dehydrogenase Glycos_transf_1 PF00534.20 ACT02796.1 - 5.8e-32 110.6 0.0 9.6e-32 109.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT02796.1 - 6e-24 85.0 0.0 1.1e-23 84.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACT02796.1 - 2.1e-20 73.4 0.0 1e-19 71.2 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACT02796.1 - 7.8e-15 55.7 0.0 8.3e-14 52.3 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 ACT02796.1 - 3.4e-05 23.7 0.2 0.0026 17.5 0.2 2.2 1 1 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_1_2 PF13524.6 ACT02796.1 - 6.7e-05 23.2 0.0 0.0002 21.7 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 ACT02796.1 - 0.00024 21.1 0.0 0.19 11.7 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase 4-like MerR_1 PF13411.6 ACT02798.1 - 1.4e-14 53.9 1.0 1.8e-14 53.5 0.1 1.7 2 1 0 2 2 2 1 MerR HTH family regulatory protein MerR PF00376.23 ACT02798.1 - 1.6e-12 47.0 0.5 4.2e-12 45.6 0.5 1.8 1 0 0 1 1 1 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT02798.1 - 4.9e-08 33.4 0.9 6.8e-08 32.9 0.9 1.2 1 0 0 1 1 1 1 MerR, DNA binding Sec34 PF04136.15 ACT02798.1 - 0.016 15.1 0.2 0.025 14.4 0.2 1.4 1 0 0 1 1 1 0 Sec34-like family DUF1043 PF06295.12 ACT02798.1 - 0.11 12.5 3.0 0.15 12.1 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) ADH_N PF08240.12 ACT02799.1 - 6.1e-30 103.3 2.1 1e-29 102.6 2.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ACT02799.1 - 6.3e-24 84.4 0.1 1.4e-23 83.3 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ACT02799.1 - 2.4e-07 30.3 0.0 4.4e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 ACT02799.1 - 6.3e-07 30.5 0.0 1.1e-06 29.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ACT02799.1 - 2.4e-05 23.8 0.0 4.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ACT02799.1 - 0.00044 20.6 0.0 0.00079 19.8 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_2 PF03446.15 ACT02799.1 - 0.00077 19.7 0.1 0.0037 17.5 0.0 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 ACT02799.1 - 0.0023 18.0 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IGFBP PF00219.18 ACT02799.1 - 0.021 15.5 2.4 0.036 14.7 2.4 1.3 1 0 0 1 1 1 0 Insulin-like growth factor binding protein 3HCDH_N PF02737.18 ACT02799.1 - 0.082 12.8 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ACT02799.1 - 0.16 12.6 1.8 1.1 9.8 0.4 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 ACT02799.1 - 0.31 10.4 2.2 0.64 9.3 1.0 1.9 1 1 1 2 2 2 0 ThiF family Beta-lactamase PF00144.24 ACT02800.1 - 9.1e-60 202.6 0.0 1.2e-59 202.2 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase GHL6 PF14871.6 ACT02801.1 - 5.7e-31 107.5 0.0 9.1e-31 106.8 0.0 1.3 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase 6 Glyco_hydro_42M PF08532.10 ACT02801.1 - 1.7e-10 40.8 0.0 2.9e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase trimerisation domain GHL10 PF02638.15 ACT02801.1 - 3.6e-05 23.0 0.0 5.6e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase-like 10 Glyco_hydro_66 PF13199.6 ACT02801.1 - 0.00053 18.8 0.0 0.64 8.6 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 66 Alpha_L_fucos PF01120.17 ACT02801.1 - 0.0071 15.8 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL15 PF14885.6 ACT02801.1 - 0.16 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 15 HTH_18 PF12833.7 ACT02802.1 - 2.2e-17 63.1 0.0 4e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02802.1 - 1.7e-16 59.8 0.5 1e-08 35.1 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02802.1 - 2.7e-06 27.3 0.2 4e-05 23.5 0.0 2.3 2 1 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02802.1 - 0.00041 20.0 0.1 0.0007 19.3 0.1 1.5 1 0 0 1 1 1 1 Cupin domain HTH_18 PF12833.7 ACT02803.1 - 1e-18 67.3 0.0 2e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02803.1 - 1.7e-18 66.2 0.3 1e-08 35.1 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02803.1 - 8.6e-12 45.1 0.1 1.6e-11 44.3 0.1 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02803.1 - 1.6e-08 34.1 0.2 3.1e-08 33.2 0.2 1.4 1 0 0 1 1 1 1 Cupin domain Ectoine_synth PF06339.12 ACT02803.1 - 0.15 12.2 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 Ectoine synthase rhaM PF05336.13 ACT02804.1 - 0.0024 17.9 2.7 1.2 9.2 0.1 3.3 2 2 0 2 2 2 2 L-rhamnose mutarotase Glyco_hydro_2_C PF02836.17 ACT02805.1 - 7.5e-24 84.4 0.0 1.3e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ACT02805.1 - 1.6e-09 38.4 0.0 3.8e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 ACT02805.1 - 4.2e-07 30.0 0.0 2.2e-06 27.7 0.0 2.2 3 0 0 3 3 3 1 Glycosyl hydrolases family 2, sugar binding domain DUF4350 PF14258.6 ACT02805.1 - 0.00018 21.9 0.0 0.29 11.6 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4350) Glyco_hydro_42 PF02449.15 ACT02805.1 - 0.0032 16.8 0.0 0.0061 16.0 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase DUF1648 PF07853.11 ACT02805.1 - 0.081 12.6 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1648) Alginate_lyase PF05426.12 ACT02806.1 - 5.2e-48 163.9 4.7 6e-48 163.7 4.7 1.1 1 0 0 1 1 1 1 Alginate lyase Big_2 PF02368.18 ACT02807.1 - 4.4e-28 97.0 8.7 2.5e-16 59.3 1.5 3.5 3 0 0 3 3 3 2 Bacterial Ig-like domain (group 2) Beta_helix PF13229.6 ACT02807.1 - 1.9e-10 40.8 12.8 1.9e-10 40.8 12.8 4.0 2 1 1 4 4 4 2 Right handed beta helix region DUF1080 PF06439.11 ACT02807.1 - 4e-10 40.1 0.1 6e-05 23.2 0.0 2.9 2 1 0 2 2 2 2 Domain of Unknown Function (DUF1080) Laminin_G_3 PF13385.6 ACT02807.1 - 4.5e-06 26.9 1.3 0.0063 16.7 0.5 3.1 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily Big_3_2 PF12245.8 ACT02807.1 - 0.006 16.8 0.9 3.1 8.1 0.1 3.0 2 0 0 2 2 2 2 Bacterial Ig-like domain CHB_HEX_C PF03174.13 ACT02807.1 - 0.0073 16.3 0.0 0.04 13.9 0.0 2.3 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain DUF4625 PF15418.6 ACT02807.1 - 0.034 14.4 0.0 7.6 6.8 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) Gal-bind_lectin PF00337.22 ACT02807.1 - 0.16 11.5 0.0 25 4.4 0.0 2.6 2 0 0 2 2 2 0 Galactoside-binding lectin Big_7 PF17957.1 ACT02807.1 - 0.86 10.4 17.3 0.64 10.8 1.7 5.0 5 0 0 5 5 5 0 Bacterial Ig domain BNR PF02012.20 ACT02807.1 - 1.2 9.4 3.1 1.4 9.2 0.4 2.7 2 0 0 2 2 2 0 BNR/Asp-box repeat BPD_transp_1 PF00528.22 ACT02808.1 - 3.5e-15 56.2 11.0 3.5e-15 56.2 11.0 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02809.1 - 1.4e-14 54.2 13.8 1.4e-14 54.2 13.8 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component UPF0182 PF03699.13 ACT02809.1 - 0.19 9.8 3.8 0.27 9.3 3.8 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0182) HTH_18 PF12833.7 ACT02811.1 - 4e-20 71.9 0.0 8.9e-20 70.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02811.1 - 4.4e-19 68.1 0.1 1.5e-10 40.9 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT02811.1 - 4.2e-05 23.8 0.0 0.00012 22.3 0.0 1.8 1 0 0 1 1 1 1 GGDEF-like domain Glyco_hydro_88 PF07470.13 ACT02812.1 - 3.7e-74 249.9 11.2 4.5e-74 249.6 11.2 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 ACT02812.1 - 0.018 13.6 0.1 0.028 12.9 0.1 1.3 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 HTH_18 PF12833.7 ACT02813.1 - 9.8e-23 80.2 0.0 2.3e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02813.1 - 5.7e-18 64.5 0.1 1.4e-07 31.5 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02813.1 - 2.6e-10 40.3 1.0 4.7e-10 39.5 1.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02813.1 - 2.4e-06 27.2 0.0 4.6e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Cupin domain PriCT_1 PF08708.11 ACT02813.1 - 0.029 14.1 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 Primase C terminal 1 (PriCT-1) HTH_Tnp_4 PF13613.6 ACT02813.1 - 0.098 12.4 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease AraC_binding PF02311.19 ACT02814.1 - 3.4e-18 65.9 0.1 5.9e-18 65.1 0.1 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_18 PF12833.7 ACT02814.1 - 3.3e-17 62.5 0.0 5.6e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02814.1 - 3e-16 59.1 0.1 1.9e-07 31.0 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family LysE PF01810.18 ACT02815.1 - 8e-16 58.1 16.5 9.6e-16 57.8 16.5 1.1 1 0 0 1 1 1 1 LysE type translocator DUF808 PF05661.12 ACT02815.1 - 0.018 14.1 0.5 0.021 13.9 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF808) HIG_1_N PF04588.13 ACT02815.1 - 0.28 11.4 0.1 0.28 11.4 0.1 2.8 4 0 0 4 4 4 0 Hypoxia induced protein conserved region Phage_holin_3_6 PF07332.11 ACT02815.1 - 4.7 7.3 14.5 7 6.7 0.1 2.4 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III NAS PF03059.16 ACT02816.1 - 5.3e-20 71.9 0.0 6.7e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 Nicotianamine synthase protein F5_F8_type_C PF00754.25 ACT02817.1 - 1.4e-31 109.3 3.8 3.1e-31 108.1 3.8 1.6 1 0 0 1 1 1 1 F5/8 type C domain F5_F8_type_C PF00754.25 ACT02818.1 - 9.5e-24 83.9 0.9 9.5e-24 83.9 0.9 2.6 3 0 0 3 3 3 1 F5/8 type C domain AP_endonuc_2 PF01261.24 ACT02819.1 - 1.6e-22 80.0 0.1 3.1e-22 79.0 0.0 1.4 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel SBP_bac_1 PF01547.25 ACT02820.1 - 1.8e-08 34.7 16.4 1.8e-08 34.7 16.4 3.1 3 1 0 3 3 3 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT02820.1 - 0.015 15.9 8.4 0.11 13.1 2.2 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF3502) Ins_allergen_rp PF06757.13 ACT02820.1 - 0.034 14.1 0.1 0.21 11.5 0.1 2.2 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification Cauli_AT PF03233.13 ACT02820.1 - 0.039 13.9 0.7 0.12 12.3 0.7 1.7 1 0 0 1 1 1 0 Aphid transmission protein BPD_transp_1 PF00528.22 ACT02821.1 - 6.2e-13 48.9 25.2 5.5e-12 45.8 25.2 2.0 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02822.1 - 7.7e-13 48.6 17.8 7.7e-13 48.6 17.8 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF4133 PF13571.6 ACT02822.1 - 0.087 13.2 0.6 0.087 13.2 0.6 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4133) DUF2189 PF09955.9 ACT02822.1 - 1.9 8.8 7.8 0.11 12.8 0.8 2.4 2 2 0 2 2 2 0 Predicted integral membrane protein (DUF2189) HTH_18 PF12833.7 ACT02823.1 - 1.4e-17 63.7 0.1 2.7e-17 62.8 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT02823.1 - 3.6e-12 46.4 0.3 3.4e-11 43.2 0.1 2.2 2 0 0 2 2 2 1 AraC-like ligand binding domain HTH_AraC PF00165.23 ACT02823.1 - 1.3e-09 37.9 0.4 0.00015 21.8 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT02823.1 - 7.4e-06 25.6 0.1 1.4e-05 24.7 0.0 1.5 2 0 0 2 2 2 1 Cupin domain AraC_binding_2 PF14525.6 ACT02823.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 AraC-binding-like domain DUF1861 PF08950.10 ACT02824.1 - 5.1e-127 423.2 0.0 5.9e-127 423.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) Lipase_GDSL_2 PF13472.6 ACT02825.1 - 1.8e-26 93.6 0.0 2.1e-26 93.4 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ACT02825.1 - 8e-12 45.6 0.0 9.2e-12 45.4 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase BPL_LplA_LipB_2 PF16917.5 ACT02825.1 - 0.14 11.7 0.0 0.43 10.1 0.0 1.7 2 0 0 2 2 2 0 Biotin/lipoate A/B protein ligase family Glyco_hydro_38N PF01074.22 ACT02826.1 - 1.8e-66 224.5 0.0 2.8e-66 223.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ACT02826.1 - 2.2e-54 184.8 0.1 1e-53 182.6 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ACT02826.1 - 5.1e-24 84.3 0.8 1.1e-23 83.2 0.8 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ACT02826.1 - 2.1e-09 37.4 0.0 5.3e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_38N PF01074.22 ACT02827.1 - 1.4e-07 31.2 0.0 2.2e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 ACT02827.1 - 1.5e-06 28.3 0.1 3.1e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_57 PF03065.15 ACT02827.1 - 0.00017 20.9 0.0 0.00036 19.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 DUF4861 PF16153.5 ACT02827.1 - 0.15 11.0 0.0 1.2 8.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4861) Glyco_hydro_43 PF04616.14 ACT02828.1 - 3.6e-55 187.3 1.1 4.1e-55 187.1 1.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 ACT02828.1 - 3.9e-05 23.4 0.2 5.9e-05 22.8 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain RepA_N PF06970.11 ACT02828.1 - 0.031 14.2 0.1 12 5.9 0.0 2.6 2 0 0 2 2 2 0 Replication initiator protein A (RepA) N-terminus DUF1175 PF06672.11 ACT02828.1 - 0.1 12.3 0.1 0.26 10.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1175) DUF2510 PF10708.9 ACT02828.1 - 0.13 12.0 2.4 0.35 10.7 2.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2510) Peripla_BP_3 PF13377.6 ACT02829.1 - 1.4e-30 106.8 0.0 2.3e-30 106.1 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT02829.1 - 4.7e-15 55.7 0.0 6.7e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family GntR PF00392.21 ACT02829.1 - 4.7e-14 51.8 0.2 2.5e-13 49.4 0.0 2.3 3 0 0 3 3 3 1 Bacterial regulatory proteins, gntR family Peripla_BP_4 PF13407.6 ACT02829.1 - 9.1e-14 51.6 0.0 1.4e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_DeoR PF08220.12 ACT02829.1 - 0.00022 20.9 0.0 0.00055 19.6 0.0 1.6 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.20 ACT02829.1 - 0.004 17.5 0.1 0.029 14.7 0.0 2.1 2 0 0 2 2 2 1 Transcriptional regulator HTH_Crp_2 PF13545.6 ACT02829.1 - 0.01 15.8 0.1 0.035 14.1 0.0 1.9 2 0 0 2 2 1 0 Crp-like helix-turn-helix domain HTH_24 PF13412.6 ACT02829.1 - 0.013 15.0 0.7 0.034 13.7 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 ACT02829.1 - 0.02 14.8 0.0 0.05 13.6 0.0 1.7 1 0 0 1 1 1 0 HTH domain RPA_C PF08784.11 ACT02829.1 - 0.025 15.2 0.0 0.062 14.0 0.0 1.6 1 0 0 1 1 1 0 Replication protein A C terminal TrmB PF01978.19 ACT02829.1 - 0.027 14.3 0.1 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Fe_dep_repress PF01325.19 ACT02829.1 - 0.043 14.0 0.1 0.099 12.9 0.1 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Phage_rep_O PF04492.13 ACT02829.1 - 0.048 14.2 0.0 0.18 12.4 0.0 1.9 2 0 0 2 2 2 0 Bacteriophage replication protein O HTH_41 PF14502.6 ACT02829.1 - 0.066 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_27 PF13463.6 ACT02829.1 - 0.094 13.2 0.0 0.31 11.6 0.0 1.9 2 0 0 2 2 1 0 Winged helix DNA-binding domain RNase_H PF00075.24 ACT02830.1 - 2.1e-05 24.8 0.0 2.6e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 RNase H RT_RNaseH_2 PF17919.1 ACT02830.1 - 0.024 14.7 0.0 0.052 13.6 0.0 1.5 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ACT02830.1 - 0.025 14.8 0.1 0.17 12.2 0.0 2.3 2 1 1 3 3 3 0 RNase H-like domain found in reverse transcriptase Spore_GerAC PF05504.11 ACT02831.1 - 6.3e-28 98.0 1.5 1e-27 97.4 1.5 1.3 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal Dev_Cell_Death PF10539.9 ACT02831.1 - 0.034 14.0 0.1 0.21 11.4 0.0 2.1 2 0 0 2 2 2 0 Development and cell death domain FlaE PF07559.14 ACT02831.1 - 0.042 14.4 1.0 0.11 13.0 0.6 2.0 2 0 0 2 2 2 0 Flagellar basal body protein FlaE Spore_permease PF03845.13 ACT02832.1 - 2.3e-88 296.2 29.3 2.9e-88 295.8 29.3 1.1 1 0 0 1 1 1 1 Spore germination protein FUSC PF04632.12 ACT02832.1 - 0.1 11.2 0.3 0.19 10.2 0.3 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family GerA PF03323.13 ACT02833.1 - 1.4e-172 574.4 4.1 1.6e-172 574.2 4.1 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein MethyTransf_Reg PF10119.9 ACT02833.1 - 0.013 16.2 0.0 0.029 15.1 0.0 1.5 1 0 0 1 1 1 0 Predicted methyltransferase regulatory domain Aldolase_II PF00596.21 ACT02834.1 - 6e-47 160.0 0.0 7.5e-47 159.7 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Glyco_transf_4 PF13439.6 ACT02834.1 - 0.018 15.0 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Peripla_BP_3 PF13377.6 ACT02835.1 - 3.8e-37 128.2 0.0 6.5e-37 127.4 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein-like domain GntR PF00392.21 ACT02835.1 - 1.1e-16 60.2 0.1 3.7e-16 58.5 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Peripla_BP_1 PF00532.21 ACT02835.1 - 7.4e-15 55.1 0.0 9.6e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT02835.1 - 2.2e-10 40.5 0.0 3e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_11 PF08279.12 ACT02835.1 - 7.7e-05 22.6 0.0 0.00019 21.3 0.0 1.6 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 ACT02835.1 - 0.00021 20.8 0.3 0.00062 19.3 0.1 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_DeoR PF08220.12 ACT02835.1 - 0.00028 20.6 0.0 0.00061 19.5 0.0 1.5 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT02835.1 - 0.00049 20.0 0.0 0.0016 18.3 0.0 1.9 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 ACT02835.1 - 0.0029 17.9 0.0 0.0068 16.7 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulator HTH_28 PF13518.6 ACT02835.1 - 0.011 15.8 0.0 0.064 13.4 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain DprA_WH PF17782.1 ACT02835.1 - 0.014 15.5 0.1 0.11 12.7 0.0 2.4 2 0 0 2 2 2 0 DprA winged helix domain LexA_DNA_bind PF01726.16 ACT02835.1 - 0.016 15.0 0.0 0.051 13.3 0.0 1.9 1 0 0 1 1 1 0 LexA DNA binding domain AbiEi_4 PF13338.6 ACT02835.1 - 0.02 15.0 0.0 0.074 13.2 0.0 2.0 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin Fe_dep_repress PF01325.19 ACT02835.1 - 0.023 14.9 0.0 0.049 13.8 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Sigma70_r4 PF04545.16 ACT02835.1 - 0.025 14.1 0.4 0.093 12.3 0.1 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_IclR PF09339.10 ACT02835.1 - 0.026 14.3 0.6 0.31 10.9 0.0 2.7 2 1 0 2 2 2 0 IclR helix-turn-helix domain HTH_23 PF13384.6 ACT02835.1 - 0.027 14.3 0.1 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 Homeodomain-like domain HTH_36 PF13730.6 ACT02835.1 - 0.029 14.3 0.0 0.064 13.2 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain TrmB PF01978.19 ACT02835.1 - 0.037 13.9 0.0 0.095 12.6 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 ACT02835.1 - 0.042 13.8 0.0 0.16 11.9 0.0 2.0 1 0 0 1 1 1 0 MarR family FeoC PF09012.10 ACT02835.1 - 0.057 13.5 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_20 PF12840.7 ACT02835.1 - 0.062 13.4 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain CobW_C PF07683.14 ACT02835.1 - 0.063 13.2 0.3 0.24 11.4 0.0 2.1 3 0 0 3 3 2 0 Cobalamin synthesis protein cobW C-terminal domain Sigma70_r4_2 PF08281.12 ACT02835.1 - 0.067 12.9 0.1 0.71 9.6 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 FaeA PF04703.12 ACT02835.1 - 0.088 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 FaeA-like protein HTH_29 PF13551.6 ACT02835.1 - 0.093 12.8 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn helix MarR PF01047.22 ACT02835.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_AsnC-type PF13404.6 ACT02835.1 - 0.13 12.1 0.1 0.63 9.9 0.0 2.2 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain FGGY_C PF02782.16 ACT02836.1 - 1e-31 110.3 0.3 1.8e-31 109.5 0.2 1.5 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ACT02836.1 - 8.4e-19 68.1 0.0 8.5e-18 64.8 0.0 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Thi4 PF01946.17 ACT02836.1 - 0.12 11.6 0.7 0.45 9.7 0.0 2.0 2 0 0 2 2 2 0 Thi4 family Cation_efflux PF01545.21 ACT02837.1 - 4.4e-50 170.2 20.2 5.4e-50 169.9 20.2 1.1 1 0 0 1 1 1 1 Cation efflux family DUF2627 PF11118.8 ACT02837.1 - 0.69 10.5 5.1 2.6 8.7 0.4 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF2627) DUF421 PF04239.12 ACT02838.1 - 2.7e-31 107.5 2.7 4.5e-28 97.2 0.3 1.7 1 1 1 2 2 2 2 Protein of unknown function (DUF421) Ribosomal_S3Ae PF01015.18 ACT02838.1 - 0.14 11.7 0.1 0.49 9.9 0.0 1.8 2 0 0 2 2 2 0 Ribosomal S3Ae family UCR_UQCRX_QCR9 PF05365.12 ACT02838.1 - 0.32 11.0 1.2 2.5 8.1 0.1 2.4 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Ni_hydr_CYTB PF01292.20 ACT02839.1 - 0.013 15.1 0.4 0.013 15.1 0.4 2.4 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 LPG_synthase_TM PF03706.13 ACT02839.1 - 0.014 15.0 14.3 0.14 11.7 9.3 2.1 1 1 1 2 2 2 0 Lysylphosphatidylglycerol synthase TM region MFS_1 PF07690.16 ACT02839.1 - 0.018 14.0 8.4 0.029 13.3 8.4 1.3 1 0 0 1 1 1 0 Major Facilitator Superfamily DUF2518 PF10726.9 ACT02839.1 - 0.02 14.6 0.6 0.02 14.6 0.6 2.0 1 1 1 2 2 2 0 Protein of function (DUF2518) DUF4405 PF14358.6 ACT02839.1 - 0.024 15.2 1.6 0.024 15.2 1.6 3.1 4 0 0 4 4 3 0 Domain of unknown function (DUF4405) SdpI PF13630.6 ACT02839.1 - 0.13 12.4 0.2 0.13 12.4 0.2 3.1 3 0 0 3 3 3 0 SdpI/YhfL protein family Ferric_reduct PF01794.19 ACT02839.1 - 0.14 12.3 17.4 0.12 12.5 7.9 3.0 2 1 1 3 3 3 0 Ferric reductase like transmembrane component Ost5 PF05251.12 ACT02839.1 - 0.16 12.3 9.2 0.92 9.8 0.5 3.5 3 1 0 3 3 3 0 Oligosaccharyltransferase subunit 5 DUF1772 PF08592.11 ACT02839.1 - 0.36 11.1 11.8 14 6.0 7.2 3.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) DUF202 PF02656.15 ACT02839.1 - 0.42 11.1 12.9 2 8.9 0.2 3.5 3 2 0 3 3 3 0 Domain of unknown function (DUF202) DUF2070 PF09843.9 ACT02839.1 - 2.2 6.5 6.5 3 6.0 6.5 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4199 PF13858.6 ACT02839.1 - 6.9 7.0 13.6 3.5 8.0 8.9 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) UPF0228 PF05727.11 ACT02840.1 - 0.025 14.4 1.2 0.062 13.1 1.1 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0228) SBP_bac_8 PF13416.6 ACT02841.1 - 4.1e-29 102.3 5.3 4.1e-29 102.3 5.3 1.5 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02841.1 - 3.8e-25 89.5 7.1 8.2e-25 88.4 7.1 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT02841.1 - 4.5e-07 29.5 0.1 0.0021 17.5 0.0 2.4 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein DUF3012 PF11216.8 ACT02841.1 - 0.1 12.6 0.7 0.25 11.4 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3012) BPD_transp_1 PF00528.22 ACT02842.1 - 1.6e-18 67.1 14.9 1.6e-18 67.1 14.9 2.1 2 1 0 3 3 3 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02843.1 - 6.4e-15 55.4 26.9 1.9e-14 53.8 24.2 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component UxuA PF03786.13 ACT02844.1 - 7.6e-88 294.7 0.0 2.1e-58 197.8 0.0 2.0 1 1 1 2 2 2 2 D-mannonate dehydratase (UxuA) AP_endonuc_2 PF01261.24 ACT02844.1 - 2.3e-10 40.3 0.0 3.6e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel HTH_18 PF12833.7 ACT02845.1 - 1.4e-19 70.1 0.1 2.5e-19 69.3 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02845.1 - 4.7e-15 55.3 0.1 1.2e-08 34.8 0.0 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT02845.1 - 4.8e-06 26.8 0.0 8e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 GGDEF-like domain FCD PF07729.12 ACT02846.1 - 1.5e-21 77.1 0.0 2.4e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 ACT02846.1 - 2.5e-15 55.9 0.7 1.4e-14 53.4 0.1 2.2 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_24 PF13412.6 ACT02846.1 - 0.00024 20.6 0.1 0.0039 16.7 0.0 2.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding PaaX PF07848.12 ACT02846.1 - 0.013 15.8 0.0 0.025 14.8 0.0 1.6 1 0 0 1 1 1 0 PaaX-like protein DUF4423 PF14394.6 ACT02846.1 - 0.016 15.0 0.1 0.025 14.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) HTH_27 PF13463.6 ACT02846.1 - 0.016 15.7 0.0 0.054 14.0 0.0 1.9 2 0 0 2 2 2 0 Winged helix DNA-binding domain TBPIP PF07106.13 ACT02846.1 - 0.018 14.9 0.1 0.22 11.5 0.0 2.3 2 0 0 2 2 2 0 TBPIP/Hop2 winged helix domain Fe_dep_repress PF01325.19 ACT02846.1 - 0.02 15.1 0.0 0.056 13.7 0.0 1.8 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_54 PF18607.1 ACT02846.1 - 0.025 14.6 0.1 0.072 13.2 0.1 1.7 2 0 0 2 2 2 0 ParA helix turn helix domain Ribosomal_L19e PF01280.20 ACT02846.1 - 0.026 14.6 0.5 0.044 13.8 0.2 1.6 2 0 0 2 2 2 0 Ribosomal protein L19e HTH_11 PF08279.12 ACT02846.1 - 0.03 14.3 0.1 0.26 11.3 0.0 2.5 2 1 0 2 2 2 0 HTH domain Intron_maturas2 PF01348.21 ACT02846.1 - 0.05 13.6 0.0 0.095 12.7 0.0 1.4 1 0 0 1 1 1 0 Type II intron maturase MarR_2 PF12802.7 ACT02846.1 - 0.055 13.4 0.2 0.22 11.4 0.0 1.9 1 1 1 2 2 2 0 MarR family HTH_5 PF01022.20 ACT02846.1 - 0.062 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family TrmB PF01978.19 ACT02846.1 - 0.066 13.1 0.0 0.18 11.7 0.0 1.9 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Rrf2 PF02082.20 ACT02846.1 - 0.085 13.2 0.2 0.34 11.3 0.1 2.0 1 1 1 2 2 2 0 Transcriptional regulator adh_short_C2 PF13561.6 ACT02847.1 - 2.6e-38 131.9 0.0 3.2e-38 131.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT02847.1 - 1e-27 96.9 0.0 1.3e-27 96.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT02847.1 - 0.00026 20.9 0.0 0.00036 20.5 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 ACT02848.1 - 1e-60 205.2 0.1 1.2e-60 205.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT02848.1 - 1.3e-54 184.6 0.2 1.6e-54 184.3 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT02848.1 - 5.3e-11 42.7 0.3 4e-10 39.9 0.1 1.9 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 ACT02848.1 - 5.7e-05 22.7 0.1 8.5e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PALP PF00291.25 ACT02848.1 - 0.0014 18.2 1.2 0.0024 17.4 1.2 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme 3HCDH_N PF02737.18 ACT02848.1 - 0.0025 17.7 1.4 0.022 14.6 1.4 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 ACT02848.1 - 0.0032 16.6 0.0 0.0038 16.4 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein AdoHcyase_NAD PF00670.21 ACT02848.1 - 0.079 13.0 0.4 0.17 12.0 0.4 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain THF_DHG_CYH_C PF02882.19 ACT02848.1 - 0.084 12.2 0.1 0.15 11.4 0.1 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 ACT02848.1 - 0.11 11.9 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase MR_MLE_C PF13378.6 ACT02849.1 - 7.1e-45 153.3 0.1 1.9e-44 151.8 0.2 1.6 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ACT02849.1 - 7e-11 42.4 0.0 1.6e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain RraA-like PF03737.15 ACT02850.1 - 1.3e-15 57.8 0.2 2.1e-15 57.2 0.2 1.3 1 0 0 1 1 1 1 Aldolase/RraA Aldo_ket_red PF00248.21 ACT02851.1 - 3e-42 144.8 0.0 1.2e-41 142.8 0.0 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family BPD_transp_1 PF00528.22 ACT02852.1 - 6e-08 32.6 24.9 9.9e-07 28.7 24.9 2.2 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT02853.1 - 2.3e-11 43.8 20.8 2.3e-11 43.8 20.8 2.4 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACT02854.1 - 8.4e-25 88.1 4.5 1.3e-24 87.5 4.5 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02854.1 - 4.6e-11 43.2 6.3 4.6e-11 43.2 6.3 2.0 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein Cytochrome_P460 PF16694.5 ACT02854.1 - 0.034 14.5 1.3 0.062 13.7 1.3 1.3 1 0 0 1 1 1 0 Cytochrome P460 HTH_18 PF12833.7 ACT02855.1 - 8.6e-22 77.2 1.5 5.6e-21 74.6 0.8 2.8 2 0 0 2 2 2 1 Helix-turn-helix domain Response_reg PF00072.24 ACT02855.1 - 6.1e-21 74.7 0.0 9.8e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT02855.1 - 4.2e-16 58.6 0.0 9.7e-07 28.7 0.0 3.0 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family His_kinase PF06580.13 ACT02856.1 - 6.1e-19 68.1 3.3 1.1e-18 67.4 0.1 2.6 3 0 0 3 3 3 1 Histidine kinase HATPase_c PF02518.26 ACT02856.1 - 6e-13 49.3 0.0 1.5e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT02856.1 - 8.8e-11 42.0 0.2 1.8e-10 41.0 0.2 1.6 1 0 0 1 1 1 1 HAMP domain ABC2_membrane_2 PF12679.7 ACT02856.1 - 0.034 13.4 1.0 0.23 10.7 0.3 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein COX6C PF02937.15 ACT02856.1 - 0.12 12.5 1.9 0.3 11.2 0.1 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc EamA PF00892.20 ACT02857.1 - 2.8e-18 66.4 39.3 1.1e-14 54.8 10.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family Response_reg PF00072.24 ACT02858.1 - 3e-26 91.8 0.1 5.4e-26 91.0 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 ACT02858.1 - 3.8e-15 55.2 0.1 5.8e-15 54.6 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_24 PF13412.6 ACT02858.1 - 0.0043 16.6 0.1 0.0083 15.7 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_23 PF13384.6 ACT02858.1 - 0.03 14.1 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain COP-gamma_platf PF08752.10 ACT02858.1 - 0.061 13.4 0.3 0.12 12.5 0.2 1.6 1 1 0 1 1 1 0 Coatomer gamma subunit appendage platform subdomain Glycos_transf_1 PF00534.20 ACT02858.1 - 0.073 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 DBD_HTH PF18430.1 ACT02858.1 - 0.15 11.9 0.1 0.83 9.5 0.0 2.1 2 0 0 2 2 2 0 Putative DNA-binding domain Sigma70_r4_2 PF08281.12 ACT02858.1 - 0.17 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 HisKA_3 PF07730.13 ACT02859.1 - 1.8e-12 47.6 1.6 1.8e-12 47.6 1.6 1.8 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACT02859.1 - 0.0085 16.6 0.6 0.15 12.6 0.3 2.7 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT02859.1 - 0.11 12.5 0.0 0.74 9.8 0.0 2.0 1 1 1 3 3 3 0 Histidine kinase-like ATPase domain ABC_tran PF00005.27 ACT02860.1 - 1.7e-32 112.8 0.0 3.3e-32 111.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02860.1 - 1.1e-08 35.3 0.1 0.00074 19.4 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 ACT02860.1 - 0.0002 22.0 0.3 0.00038 21.1 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_23 PF13476.6 ACT02860.1 - 0.0043 17.6 0.3 0.0084 16.6 0.3 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT02860.1 - 0.012 15.5 0.2 0.029 14.3 0.1 1.7 2 0 0 2 2 2 0 RsgA GTPase KdpD PF02702.17 ACT02860.1 - 0.015 14.8 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain AAA_29 PF13555.6 ACT02860.1 - 0.015 15.0 0.1 0.031 14.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 ACT02860.1 - 0.042 13.3 0.2 0.7 9.3 0.2 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain SRP54 PF00448.22 ACT02860.1 - 0.079 12.6 0.0 0.36 10.4 0.0 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_15 PF13175.6 ACT02860.1 - 0.11 12.2 0.8 0.38 10.4 0.4 1.9 1 1 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 ACT02860.1 - 0.13 12.0 0.1 2 8.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 ACT02860.1 - 0.13 11.8 0.1 0.28 10.8 0.0 1.5 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 ACT02861.1 - 4.4e-24 85.2 15.6 5.5e-24 84.9 15.6 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 ACT02861.1 - 1.2e-20 73.8 10.6 1.4e-18 67.1 7.6 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC2_membrane_2 PF12679.7 ACT02861.1 - 4.6e-17 62.2 9.2 6.6e-17 61.7 9.2 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 ACT02861.1 - 8.4e-05 22.6 7.1 8.6e-05 22.6 4.1 2.2 2 0 0 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_5 PF13346.6 ACT02861.1 - 0.034 13.7 14.1 0.031 13.8 11.1 2.2 2 1 0 2 2 2 0 ABC-2 family transporter protein ABC2_membrane_3 PF12698.7 ACT02862.1 - 3e-47 161.4 15.2 3.4e-47 161.2 15.2 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 ACT02862.1 - 8.6e-27 93.9 5.9 8.6e-27 93.9 5.9 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC2_membrane_2 PF12679.7 ACT02862.1 - 4.9e-18 65.4 11.2 9.8e-18 64.4 11.2 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 ACT02862.1 - 8.3e-07 29.1 8.1 8.3e-07 29.1 8.1 2.6 2 1 0 3 3 3 1 ABC-2 family transporter protein ABC2_membrane_5 PF13346.6 ACT02862.1 - 0.11 12.0 17.8 0.044 13.3 12.8 2.3 2 1 0 2 2 2 0 ABC-2 family transporter protein ABC_tran PF00005.27 ACT02863.1 - 1.2e-38 132.8 1.0 4.3e-18 66.1 0.0 4.3 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 ACT02863.1 - 3.8e-12 46.6 7.7 2.9e-05 24.0 0.0 4.6 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT02863.1 - 1.7e-09 37.4 4.2 0.00062 19.3 0.0 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT02863.1 - 2.5e-05 23.9 0.2 0.076 12.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Dynamin_N PF00350.23 ACT02863.1 - 0.00034 20.7 7.7 0.22 11.5 0.0 4.3 3 2 0 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 ACT02863.1 - 0.00059 19.8 0.1 1.1 9.2 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ACT02863.1 - 0.0026 17.8 2.7 0.49 10.5 0.1 3.3 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_15 PF13175.6 ACT02863.1 - 0.0027 17.5 19.8 0.066 12.9 2.4 4.0 2 2 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.6 ACT02863.1 - 0.017 15.3 0.1 4.2 7.7 0.0 3.8 3 1 0 3 3 3 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 ACT02863.1 - 0.03 14.8 16.8 1.3 9.4 1.2 3.5 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.6 ACT02863.1 - 0.037 14.4 0.0 6.4 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 ACT02863.1 - 0.049 14.0 0.5 28 5.2 0.0 3.5 4 0 0 4 4 4 0 RNA helicase TsaE PF02367.17 ACT02863.1 - 0.053 13.5 0.1 14 5.7 0.0 2.8 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ACT02863.1 - 0.059 13.3 0.1 2.3 8.1 0.0 2.5 2 0 0 2 2 2 0 NACHT domain ABC_tran_Xtn PF12848.7 ACT02863.1 - 0.17 11.9 8.7 1.4 9.0 8.7 2.4 1 1 0 1 1 1 0 ABC transporter DoxX_2 PF13564.6 ACT02864.1 - 4.8e-11 42.7 9.5 6.1e-11 42.3 9.5 1.1 1 0 0 1 1 1 1 DoxX-like family DoxX PF07681.12 ACT02864.1 - 1.7e-05 25.3 13.0 2.9e-05 24.6 13.0 1.4 1 0 0 1 1 1 1 DoxX DUF4225 PF13988.6 ACT02864.1 - 3.9 7.0 5.1 13 5.3 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4225) MarR PF01047.22 ACT02865.1 - 1.3e-12 47.4 0.0 1.9e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT02865.1 - 2.9e-09 37.3 0.1 4.1e-09 36.8 0.1 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR_2 PF12802.7 ACT02865.1 - 5.1e-08 32.7 0.0 8.5e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT02865.1 - 8.7e-07 28.4 0.0 1.4e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 ACT02865.1 - 3.7e-05 23.5 0.0 5.5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 ACT02865.1 - 0.00043 20.0 0.0 0.00074 19.3 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain Penicillinase_R PF03965.16 ACT02865.1 - 0.00047 20.5 0.3 0.0022 18.3 0.3 1.9 1 1 0 1 1 1 1 Penicillinase repressor HTH_11 PF08279.12 ACT02865.1 - 0.00049 20.0 0.1 0.0012 18.7 0.1 1.6 1 0 0 1 1 1 1 HTH domain B-block_TFIIIC PF04182.12 ACT02865.1 - 0.0024 18.0 0.0 0.0038 17.3 0.0 1.4 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_Crp_2 PF13545.6 ACT02865.1 - 0.0025 17.7 0.0 0.0044 17.0 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_20 PF12840.7 ACT02865.1 - 0.0062 16.6 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HxlR PF01638.17 ACT02865.1 - 0.0079 16.0 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_36 PF13730.6 ACT02865.1 - 0.0093 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Rrf2 PF02082.20 ACT02865.1 - 0.011 16.0 0.0 0.027 14.8 0.0 1.6 2 0 0 2 2 1 0 Transcriptional regulator Fe_dep_repress PF01325.19 ACT02865.1 - 0.017 15.3 0.0 0.027 14.7 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_38 PF13936.6 ACT02865.1 - 0.021 14.6 0.0 0.067 13.0 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain DDE_Tnp_IS1 PF03400.13 ACT02865.1 - 0.029 14.7 0.3 0.17 12.2 0.3 2.0 1 1 0 1 1 1 0 IS1 transposase HTH_45 PF14947.6 ACT02865.1 - 0.033 14.2 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix Stk19 PF10494.9 ACT02865.1 - 0.05 13.3 0.2 0.061 13.0 0.2 1.1 1 0 0 1 1 1 0 Serine-threonine protein kinase 19 SecA_PP_bind PF01043.20 ACT02865.1 - 0.062 14.0 0.1 0.091 13.4 0.1 1.3 1 0 0 1 1 1 0 SecA preprotein cross-linking domain PI31_Prot_N PF11566.8 ACT02865.1 - 0.062 13.1 0.0 0.098 12.5 0.0 1.3 1 0 0 1 1 1 0 PI31 proteasome regulator N-terminal HTH_29 PF13551.6 ACT02865.1 - 0.16 12.0 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix GTP_EFTU PF00009.27 ACT02866.1 - 5.7e-41 140.2 0.1 8.9e-41 139.6 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ACT02866.1 - 4.1e-05 23.6 0.0 0.00039 20.5 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase APS_kinase PF01583.20 ACT02866.1 - 9.1e-05 22.4 0.0 0.0037 17.2 0.0 2.4 1 1 0 1 1 1 1 Adenylylsulphate kinase ProQ_C PF17516.2 ACT02866.1 - 0.0034 16.8 0.7 0.0066 15.8 0.1 1.8 2 0 0 2 2 2 1 ProQ C-terminal domain GTP_EFTU_D2 PF03144.25 ACT02866.1 - 0.02 15.3 0.3 0.078 13.4 0.1 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 2 Shikimate_DH PF01488.20 ACT02866.1 - 0.087 12.9 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GTP_EFTU_D4 PF14578.6 ACT02866.1 - 0.1 12.5 0.1 0.68 9.9 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 4 PAPS_reduct PF01507.19 ACT02867.1 - 2.8e-62 209.8 0.0 3.4e-62 209.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Cu_amine_oxidN1 PF07833.11 ACT02868.1 - 2.2e-14 53.7 1.2 4.4e-14 52.7 0.0 2.1 3 0 0 3 3 3 1 Copper amine oxidase N-terminal domain DUF3298 PF11738.8 ACT02868.1 - 3.9e-11 43.8 0.5 1.2e-10 42.3 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3298) PdaC PF13739.6 ACT02868.1 - 4.9e-11 43.4 2.9 5.4e-10 40.1 0.8 2.6 2 0 0 2 2 2 1 Deacetylase PdaC Lipase_GDSL_2 PF13472.6 ACT02869.1 - 1.3e-13 51.8 0.0 2.9e-13 50.6 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family CE2_N PF17996.1 ACT02869.1 - 0.08 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal Lipase_GDSL PF00657.22 ACT02869.1 - 0.16 11.9 0.0 1.2 9.0 0.0 2.2 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Glyco_hydro_10 PF00331.20 ACT02870.1 - 8.4e-111 370.1 0.4 9.8e-111 369.9 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Glyco_hydro_42 PF02449.15 ACT02870.1 - 0.00085 18.8 0.1 0.0013 18.1 0.1 1.3 1 0 0 1 1 1 1 Beta-galactosidase BPD_transp_1 PF00528.22 ACT02871.1 - 5.7e-16 58.8 17.5 5.7e-16 58.8 17.5 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF1772 PF08592.11 ACT02871.1 - 0.014 15.7 3.4 0.014 15.7 3.4 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) BPD_transp_1 PF00528.22 ACT02872.1 - 2e-09 37.4 3.7 2e-09 37.4 3.7 2.8 3 0 0 3 3 3 2 Binding-protein-dependent transport system inner membrane component Aldedh PF00171.22 ACT02872.1 - 0.075 11.5 0.1 0.16 10.5 0.0 1.5 1 1 0 1 1 1 0 Aldehyde dehydrogenase family Arabino_trans_C PF14896.6 ACT02873.1 - 0.053 12.5 0.2 7.8 5.4 0.0 2.6 3 0 0 3 3 3 0 EmbC C-terminal domain BPD_transp_1 PF00528.22 ACT02874.1 - 2.3e-13 50.3 33.0 1.1e-11 44.8 33.0 2.5 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component HKR_ArcB_TM PF18415.1 ACT02874.1 - 2.7 8.9 9.5 24 5.8 1.2 3.4 3 0 0 3 3 3 0 Histidine kinase receptor ArcB trans-membrane domain BPD_transp_1 PF00528.22 ACT02875.1 - 1.8e-09 37.6 17.2 1.8e-09 37.6 17.2 2.3 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACT02876.1 - 1.3e-19 71.2 4.0 1.3e-19 71.2 4.0 1.8 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02876.1 - 6.5e-13 49.3 4.4 6.5e-13 49.3 4.4 2.2 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein CBM_35 PF16990.5 ACT02876.1 - 0.014 15.7 0.0 0.47 10.7 0.0 2.5 2 0 0 2 2 2 0 Carbohydrate binding module (family 35) EKLF_TAD1 PF16832.5 ACT02876.1 - 0.37 10.7 2.4 0.88 9.5 2.4 1.6 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 1 SBP_bac_1 PF01547.25 ACT02877.1 - 4.9e-22 79.3 10.2 4.9e-22 79.3 10.2 1.5 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT02877.1 - 1.3e-21 77.6 8.0 2.1e-21 77.0 8.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SSP160 PF06933.11 ACT02877.1 - 1.1 7.4 7.9 1.5 6.9 7.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 HTH_18 PF12833.7 ACT02878.1 - 2.7e-15 56.4 0.1 7.2e-15 55.0 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02878.1 - 2.1e-12 46.8 0.1 7e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Response_reg PF00072.24 ACT02878.1 - 1.6e-11 44.4 0.0 2.8e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain DUF2164 PF09932.9 ACT02878.1 - 0.016 15.3 0.0 4.7 7.3 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2164) Glyco_hydro_10 PF00331.20 ACT02879.1 - 1.1e-114 382.8 1.1 1.1e-114 382.8 1.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 10 CBM9_1 PF06452.11 ACT02879.1 - 2.9e-79 265.3 9.5 5.7e-53 179.6 2.5 2.5 2 0 0 2 2 2 2 Carbohydrate family 9 binding domain-like CBM_4_9 PF02018.17 ACT02879.1 - 6.2e-24 84.8 3.0 3.4e-23 82.5 3.0 2.3 1 0 0 1 1 1 1 Carbohydrate binding domain Glyco_hydro_42 PF02449.15 ACT02879.1 - 0.00038 19.9 0.0 0.00071 19.0 0.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase PA-IIL PF07472.11 ACT02879.1 - 0.17 12.2 1.2 36 4.7 0.0 3.3 3 0 0 3 3 3 0 Fucose-binding lectin II (PA-IIL) ABC_tran PF00005.27 ACT02880.1 - 3.4e-31 108.6 0.0 6.1e-31 107.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02880.1 - 2.3e-10 40.8 2.4 2.5e-06 27.5 0.1 2.6 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT02880.1 - 1.7e-06 27.7 0.8 3.2e-05 23.5 0.8 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ACT02880.1 - 9.7e-05 22.3 0.1 0.00023 21.1 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ACT02880.1 - 0.0002 21.0 0.2 0.00039 20.1 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 ACT02880.1 - 0.00022 21.4 0.1 0.0046 17.2 0.1 2.5 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 ACT02880.1 - 0.00033 21.1 0.5 0.00091 19.7 0.2 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ACT02880.1 - 0.0055 17.0 1.1 0.022 15.0 0.0 2.2 3 0 0 3 3 2 1 AAA domain TniB PF05621.11 ACT02880.1 - 0.011 15.2 0.3 0.35 10.3 0.1 2.4 2 0 0 2 2 2 0 Bacterial TniB protein AAA_15 PF13175.6 ACT02880.1 - 0.015 15.1 0.2 0.14 11.8 0.1 2.0 1 1 1 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 ACT02880.1 - 0.019 15.0 0.8 0.041 14.0 0.1 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 ACT02880.1 - 0.022 15.3 0.4 0.062 13.8 0.0 1.8 2 1 0 2 2 2 0 AAA domain G-alpha PF00503.20 ACT02880.1 - 0.043 13.0 0.0 0.048 12.8 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_30 PF13604.6 ACT02880.1 - 0.05 13.3 0.3 1 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ACT02880.1 - 0.071 13.3 0.3 1.7 8.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain FeoB_N PF02421.18 ACT02880.1 - 0.072 12.6 0.3 0.39 10.2 0.1 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.6 ACT02880.1 - 0.074 12.8 0.1 0.54 10.0 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ACT02880.1 - 0.087 12.4 0.0 3.2 7.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 ACT02880.1 - 0.09 12.8 0.2 0.2 11.7 0.2 1.6 1 0 0 1 1 1 0 Dynamin family Mg_chelatase PF01078.21 ACT02880.1 - 0.16 11.3 0.1 16 4.8 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 ACT02880.1 - 0.31 10.9 1.1 0.44 10.4 0.3 1.7 2 0 0 2 2 2 0 NACHT domain FtsX PF02687.21 ACT02881.1 - 5.7e-11 42.8 14.8 6e-07 29.9 3.6 4.6 5 1 1 6 6 6 2 FtsX-like permease family MacB_PCD PF12704.7 ACT02881.1 - 5.2e-10 40.0 0.3 4e-07 30.6 0.0 2.7 3 0 0 3 3 3 2 MacB-like periplasmic core domain Abhydrolase_9_N PF15420.6 ACT02881.1 - 0.17 11.8 12.7 0.018 15.0 2.0 3.2 2 1 1 3 3 3 0 Alpha/beta-hydrolase family N-terminus Claudin_2 PF13903.6 ACT02881.1 - 4.2 7.1 8.4 0.24 11.2 0.5 2.4 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Biotin_lipoyl_2 PF13533.6 ACT02882.1 - 3.6e-11 42.7 1.1 2.6e-09 36.7 0.3 2.6 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_D23 PF16576.5 ACT02882.1 - 8.5e-11 41.5 1.0 1.4e-10 40.8 1.0 1.4 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 ACT02882.1 - 1.5e-08 35.3 3.2 4.7e-05 24.1 0.3 2.9 2 1 1 3 3 3 2 HlyD family secretion protein Biotin_lipoyl PF00364.22 ACT02882.1 - 2.8e-05 23.8 0.0 0.023 14.5 0.0 2.6 2 0 0 2 2 2 2 Biotin-requiring enzyme Peptidase_M23 PF01551.22 ACT02882.1 - 0.00034 20.8 0.3 0.23 11.7 0.0 2.6 2 0 0 2 2 2 2 Peptidase family M23 PTS_EIIA_1 PF00358.20 ACT02882.1 - 0.013 15.3 0.2 0.68 9.7 0.0 2.9 3 1 1 4 4 4 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 RnfC_N PF13375.6 ACT02882.1 - 0.016 15.2 0.2 5.8 6.9 0.0 2.7 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain PYNP_C PF07831.13 ACT02882.1 - 0.022 14.4 0.1 2.4 7.9 0.0 2.5 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain LPAM_1 PF08139.12 ACT02882.1 - 0.51 10.9 2.8 0.46 11.1 1.4 1.7 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site ABC_tran PF00005.27 ACT02883.1 - 3.9e-33 114.9 0.0 5.2e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02883.1 - 3.5e-06 27.0 0.0 0.048 13.5 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ACT02883.1 - 0.00031 20.6 0.0 0.14 11.8 0.0 2.1 1 1 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 ACT02883.1 - 0.00061 19.3 0.1 0.0082 15.6 0.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT02883.1 - 0.00091 19.5 0.7 0.017 15.4 0.7 2.1 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT02883.1 - 0.0019 17.9 0.1 0.0037 17.0 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT02883.1 - 0.0039 17.1 0.1 0.0063 16.4 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 ACT02883.1 - 0.0068 16.2 0.8 0.019 14.7 0.8 1.8 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 ACT02883.1 - 0.012 15.5 0.1 0.037 14.0 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 ACT02883.1 - 0.017 15.5 0.2 0.024 15.0 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 ACT02883.1 - 0.028 14.0 0.2 0.15 11.7 0.0 2.0 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ACT02883.1 - 0.031 14.2 0.2 3 7.7 0.0 2.2 2 0 0 2 2 2 0 NTPase NB-ARC PF00931.22 ACT02883.1 - 0.079 12.1 0.0 0.28 10.3 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain DLIC PF05783.11 ACT02883.1 - 0.22 10.3 0.0 0.31 9.8 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Glyco_hydro_10 PF00331.20 ACT02884.1 - 4.9e-106 354.5 0.0 5.4e-106 354.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 AP_endonuc_2 PF01261.24 ACT02884.1 - 2.8e-05 23.6 0.0 0.007 15.8 0.0 2.2 2 0 0 2 2 2 2 Xylose isomerase-like TIM barrel Methyltransf_25 PF13649.6 ACT02884.1 - 0.007 17.0 0.0 0.027 15.2 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain GH43_C2 PF17851.1 ACT02885.1 - 7.8e-45 153.1 0.0 1.1e-44 152.6 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Glyco_hydro_43 PF04616.14 ACT02885.1 - 4e-40 137.9 0.0 1.2e-39 136.4 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 43 DUF1854 PF08909.11 ACT02886.1 - 2.2e-39 134.2 0.0 2.6e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1854) ABC_membrane PF00664.23 ACT02887.1 - 1.7e-42 145.9 8.8 2.3e-42 145.5 8.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT02887.1 - 1.6e-36 125.9 0.0 2.7e-36 125.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT02887.1 - 0.0002 20.9 0.4 0.0042 16.6 0.0 2.0 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ACT02887.1 - 0.00061 19.7 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase SbcCD_C PF13558.6 ACT02887.1 - 0.0012 19.1 0.1 0.019 15.2 0.1 2.5 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 ACT02887.1 - 0.0044 16.8 0.0 0.0068 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ACT02887.1 - 0.0049 16.9 0.0 0.016 15.3 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ACT02887.1 - 0.01 16.3 0.2 0.035 14.5 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ACT02887.1 - 0.014 15.8 0.0 0.086 13.3 0.0 2.2 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) DZR PF12773.7 ACT02887.1 - 0.016 15.3 0.6 0.03 14.4 0.6 1.4 1 0 0 1 1 1 0 Double zinc ribbon AAA_29 PF13555.6 ACT02887.1 - 0.027 14.2 0.0 0.073 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2116 PF09889.9 ACT02887.1 - 0.053 13.5 0.6 0.19 11.7 0.6 2.0 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) AAA_22 PF13401.6 ACT02887.1 - 0.072 13.4 0.3 0.95 9.7 0.3 2.3 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ACT02887.1 - 0.091 12.5 0.0 0.3 10.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ACT02887.1 - 0.098 13.1 0.1 0.22 12.0 0.0 1.5 2 0 0 2 2 2 0 AAA domain zf-ribbon_3 PF13248.6 ACT02887.1 - 0.12 11.8 3.4 0.26 10.7 3.4 1.5 1 0 0 1 1 1 0 zinc-ribbon domain ABC_membrane_3 PF13748.6 ACT02887.1 - 0.49 9.6 5.1 1.6 7.9 5.1 1.8 1 1 0 1 1 1 0 ABC transporter transmembrane region zinc_ribbon_2 PF13240.6 ACT02887.1 - 0.76 9.6 2.8 1.8 8.4 2.8 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Auto_anti-p27 PF06677.12 ACT02887.1 - 1.9 8.7 4.1 3.7 7.8 4.1 1.5 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Melibiase_2 PF16499.5 ACT02888.1 - 5.6e-71 239.0 8.2 2.8e-70 236.7 6.8 2.6 2 1 0 2 2 2 1 Alpha galactosidase A Melibiase PF02065.18 ACT02888.1 - 1.9e-10 40.2 0.1 4.8e-10 38.9 0.0 1.5 2 0 0 2 2 2 1 Melibiase Melibiase_C PF17801.1 ACT02888.1 - 6.7e-10 38.9 0.0 1.5e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Glyco_hydro_97 PF10566.9 ACT02888.1 - 0.00027 20.3 0.0 0.0004 19.7 0.0 1.2 1 0 0 1 1 1 1 Glycoside hydrolase 97 Raffinose_syn PF05691.12 ACT02888.1 - 0.1 10.4 0.1 0.14 9.9 0.1 1.1 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 DUF3197 PF11432.8 ACT02889.1 - 0.051 13.5 0.0 0.059 13.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3197) zf-LYAR PF08790.11 ACT02889.1 - 0.25 11.3 1.9 14 5.7 0.1 2.3 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zinc_ribbon_2 PF13240.6 ACT02889.1 - 1.5 8.6 5.2 4.7 7.1 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain HTH_18 PF12833.7 ACT02890.1 - 1.7e-21 76.2 0.1 3.5e-21 75.3 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT02890.1 - 5.4e-17 62.0 0.0 7.9e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_AraC PF00165.23 ACT02890.1 - 4.3e-15 55.4 1.3 1.3e-09 37.9 0.2 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT02890.1 - 9e-05 22.1 0.0 0.0002 21.0 0.0 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding_2 PF14525.6 ACT02890.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 AraC-binding-like domain Glyco_hydro_43 PF04616.14 ACT02891.1 - 1.7e-36 126.1 0.4 2.4e-36 125.5 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 CBM_6 PF03422.15 ACT02891.1 - 8e-25 87.6 0.2 8e-25 87.6 0.2 2.3 2 1 0 2 2 2 1 Carbohydrate binding module (family 6) DUF5010_C PF18099.1 ACT02891.1 - 0.00091 19.3 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 DUF5010 C-terminal domain Response_reg PF00072.24 ACT02892.1 - 7.6e-22 77.6 0.0 3.5e-21 75.5 0.0 2.2 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02892.1 - 3.6e-20 72.0 0.0 1.3e-19 70.3 0.0 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02892.1 - 3.3e-12 46.2 0.0 2.3e-06 27.5 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family SPOB_a PF14689.6 ACT02892.1 - 0.016 14.9 3.8 0.13 12.0 0.4 3.7 4 0 0 4 4 4 0 Sensor_kinase_SpoOB-type, alpha-helical domain Complex1_LYR_2 PF13233.6 ACT02892.1 - 0.1 13.4 0.2 0.34 11.7 0.2 2.0 1 0 0 1 1 1 0 Complex1_LYR-like Uteroglobin PF01099.17 ACT02892.1 - 0.13 12.6 0.2 0.79 10.1 0.1 2.4 2 0 0 2 2 2 0 Uteroglobin family His_kinase PF06580.13 ACT02893.1 - 1.1e-16 60.9 0.7 1.1e-16 60.9 0.7 2.2 2 0 0 2 2 2 1 Histidine kinase HAMP PF00672.25 ACT02893.1 - 1e-05 25.8 0.0 2.7e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 HAMP domain dCache_1 PF02743.18 ACT02893.1 - 2.6e-05 24.1 5.4 2.6e-05 24.1 5.4 1.7 2 0 0 2 2 2 1 Cache domain HATPase_c_5 PF14501.6 ACT02893.1 - 0.053 13.4 0.6 0.22 11.4 0.1 2.3 2 0 0 2 2 2 0 GHKL domain HATPase_c PF02518.26 ACT02893.1 - 0.072 13.6 0.6 1.6 9.2 0.1 2.4 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TetR_C_17 PF17922.1 ACT02893.1 - 0.084 13.0 1.9 1.4 9.1 0.2 2.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF4479 PF14794.6 ACT02893.1 - 0.11 12.3 0.0 0.31 10.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4479) SBP_bac_1 PF01547.25 ACT02894.1 - 1.8e-21 77.4 7.4 3.7e-21 76.4 7.4 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein RicinB_lectin_2 PF14200.6 ACT02895.1 - 3.4e-28 98.2 22.5 1e-16 61.5 6.8 3.7 3 1 0 4 4 4 2 Ricin-type beta-trefoil lectin domain-like Cellulase PF00150.18 ACT02895.1 - 1.6e-15 57.3 7.8 3.2e-15 56.3 7.8 1.5 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ricin_B_lectin PF00652.22 ACT02895.1 - 1.3e-13 51.3 3.9 1.3e-13 51.3 3.9 2.2 3 0 0 3 3 3 1 Ricin-type beta-trefoil lectin domain HTH_18 PF12833.7 ACT02896.1 - 2.7e-17 62.8 0.4 6.6e-17 61.5 0.0 1.9 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02896.1 - 1.6e-14 53.5 0.0 1.3e-08 34.8 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Sec15 PF04091.12 ACT02896.1 - 0.074 12.4 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 Exocyst complex subunit Sec15-like COesterase PF00135.28 ACT02897.1 - 3.3e-93 313.3 0.1 9.7e-92 308.5 0.1 2.0 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ACT02897.1 - 7e-07 29.3 0.4 4.1e-06 26.8 0.4 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ACT02897.1 - 0.018 14.5 0.0 0.037 13.5 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family Glyco_hyd_65N_2 PF14498.6 ACT02898.1 - 2e-71 240.6 0.0 9.6e-71 238.4 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, N-terminal domain Bac_rhamnosid6H PF17389.2 ACT02898.1 - 0.089 12.0 0.2 0.15 11.3 0.2 1.2 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydro_65N PF03636.15 ACT02898.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Response_reg PF00072.24 ACT02899.1 - 7.6e-21 74.4 0.0 1.5e-20 73.4 0.0 1.5 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02899.1 - 1.4e-18 66.9 0.0 2.9e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02899.1 - 7.3e-13 48.3 0.1 6.9e-07 29.2 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family UPF0122 PF04297.14 ACT02899.1 - 0.0042 17.3 0.2 0.0079 16.4 0.2 1.4 1 0 0 1 1 1 1 Putative helix-turn-helix protein, YlxM / p13 like Rrf2 PF02082.20 ACT02899.1 - 0.017 15.4 0.0 0.048 14.0 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator DUF1263 PF06882.12 ACT02899.1 - 0.19 11.8 0.0 0.31 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1263) His_kinase PF06580.13 ACT02900.1 - 5.8e-22 77.8 0.7 1.5e-21 76.5 0.7 1.8 1 0 0 1 1 1 1 Histidine kinase HATPase_c PF02518.26 ACT02900.1 - 8.4e-10 39.1 0.0 1.7e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT02900.1 - 8.6e-07 29.2 0.3 2.1e-06 28.0 0.3 1.7 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 ACT02900.1 - 0.0027 17.6 0.0 0.0065 16.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACT02900.1 - 0.0031 17.3 2.1 0.0068 16.2 2.1 1.5 1 0 0 1 1 1 1 Cache domain HATPase_c_5 PF14501.6 ACT02900.1 - 0.01 15.7 0.0 0.036 14.0 0.0 1.9 1 0 0 1 1 1 0 GHKL domain Glyco_hydro_127 PF07944.12 ACT02901.1 - 4.1e-93 312.6 0.0 5.1e-93 312.3 0.0 1.1 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 SBP_bac_1 PF01547.25 ACT02902.1 - 2.9e-10 40.6 8.0 7.8e-10 39.2 8.0 1.8 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF4969 PF16339.5 ACT02902.1 - 0.015 15.6 0.3 0.05 14.0 0.3 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4969) SBP_bac_11 PF13531.6 ACT02902.1 - 0.097 12.4 0.0 0.51 10.0 0.0 2.0 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT02902.1 - 0.15 12.7 4.8 0.42 11.2 4.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3502) BPD_transp_1 PF00528.22 ACT02903.1 - 1e-08 35.1 25.6 8e-08 32.2 25.6 2.0 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component E1-E2_ATPase PF00122.20 ACT02903.1 - 0.046 13.3 0.6 0.046 13.3 0.6 2.8 3 1 1 4 4 4 0 E1-E2 ATPase BPD_transp_1 PF00528.22 ACT02904.1 - 6.7e-14 52.0 13.6 6.7e-14 52.0 13.6 2.1 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Cytochrom_B558a PF05038.13 ACT02904.1 - 0.0021 17.7 0.1 0.0044 16.6 0.1 1.5 1 0 0 1 1 1 1 Cytochrome Cytochrome b558 alpha-subunit DUF2189 PF09955.9 ACT02904.1 - 0.052 13.8 7.0 0.15 12.3 6.0 2.3 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2189) OppC_N PF12911.7 ACT02904.1 - 0.073 13.1 5.4 2.4 8.2 0.4 3.8 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C NPCC PF08058.11 ACT02904.1 - 0.92 9.6 3.0 0.79 9.8 0.9 1.9 2 0 0 2 2 2 0 Nuclear pore complex component Phage_holin_3_5 PF16085.5 ACT02904.1 - 0.99 9.6 4.2 0.31 11.2 0.9 1.9 2 0 0 2 2 2 0 Bacteriophage holin Hol, superfamily III HTH_18 PF12833.7 ACT02905.1 - 1.9e-19 69.7 0.1 3.6e-18 65.6 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02905.1 - 3.8e-15 55.5 0.3 4.1e-10 39.5 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02905.1 - 1.4e-08 34.7 0.4 3.4e-08 33.5 0.2 1.8 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02905.1 - 3e-05 23.6 0.0 5e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Cupin domain HTH_5 PF01022.20 ACT02905.1 - 0.044 13.7 0.0 3.8 7.5 0.0 2.4 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family rve_2 PF13333.6 ACT02905.1 - 0.071 13.3 1.4 10 6.4 0.0 2.9 3 0 0 3 3 3 0 Integrase core domain HTH_IclR PF09339.10 ACT02905.1 - 0.1 12.4 0.0 14 5.6 0.0 2.7 3 0 0 3 3 3 0 IclR helix-turn-helix domain Glyco_hydro_127 PF07944.12 ACT02906.1 - 1.7e-136 455.8 1.1 2.1e-136 455.5 1.1 1.1 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 DUF4986 PF16375.5 ACT02906.1 - 0.011 16.4 0.1 0.034 14.8 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function Glyco_transf_6 PF03414.13 ACT02906.1 - 0.072 11.8 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 6 SLH PF00395.20 ACT02907.1 - 1.5e-26 92.1 7.3 4.8e-10 39.3 0.2 3.8 4 0 0 4 4 4 3 S-layer homology domain DUF3197 PF11432.8 ACT02907.1 - 0.0022 17.8 0.1 0.0046 16.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3197) Cohesin PF00963.18 ACT02908.1 - 4.9e-12 46.3 3.1 2.8e-11 43.8 3.1 2.4 1 0 0 1 1 1 1 Cohesin domain FIVAR PF07554.13 ACT02908.1 - 2.8e-08 34.4 5.4 1.2e-06 29.2 0.8 3.1 2 0 0 2 2 2 2 FIVAR domain Laminin_G_3 PF13385.6 ACT02908.1 - 1.6e-06 28.3 3.2 1.6e-06 28.3 3.2 3.6 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily BPD_transp_1 PF00528.22 ACT02909.1 - 2.2e-17 63.4 13.6 2.4e-17 63.3 12.8 1.5 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF3671 PF12420.8 ACT02909.1 - 5.3 7.2 12.3 4 7.5 2.2 2.4 2 1 1 3 3 3 0 Protein of unknown function BPD_transp_1 PF00528.22 ACT02910.1 - 9.1e-11 41.8 22.2 4.1e-10 39.7 22.2 1.9 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_1 PF01547.25 ACT02911.1 - 1.4e-31 110.6 9.0 2.2e-31 110.0 9.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT02911.1 - 8.9e-28 97.9 5.3 1.3e-27 97.3 5.3 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Glyco_trans_4_3 PF12000.8 ACT02911.1 - 0.078 12.7 0.0 0.67 9.6 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 4 group Response_reg PF00072.24 ACT02912.1 - 8.9e-26 90.3 0.0 2.1e-25 89.0 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT02912.1 - 1.1e-17 64.1 0.0 5.1e-17 61.9 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02912.1 - 4.6e-17 61.6 0.1 1.4e-09 37.8 0.0 2.9 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT02912.1 - 8.9e-12 45.3 0.0 2e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 GGDEF-like domain Cnd1 PF12717.7 ACT02912.1 - 0.0076 16.3 0.6 0.018 15.1 0.6 1.6 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 dCache_1 PF02743.18 ACT02913.1 - 1.7e-22 80.4 4.2 2.9e-22 79.7 4.2 1.4 1 0 0 1 1 1 1 Cache domain His_kinase PF06580.13 ACT02913.1 - 2e-17 63.3 0.7 2e-17 63.3 0.7 2.3 2 0 0 2 2 2 1 Histidine kinase HAMP PF00672.25 ACT02913.1 - 2.6e-08 34.1 0.0 5.9e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT02913.1 - 2.8e-07 31.0 0.2 9.9e-07 29.3 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT02913.1 - 0.01 15.7 0.3 0.041 13.8 0.0 2.2 2 0 0 2 2 2 0 GHKL domain HATPase_c_2 PF13581.6 ACT02913.1 - 0.015 15.3 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Cache_3-Cache_2 PF17201.4 ACT02913.1 - 0.05 12.9 0.1 0.11 11.7 0.1 1.6 1 0 0 1 1 1 0 Cache 3/Cache 2 fusion domain HATPase_c_3 PF13589.6 ACT02913.1 - 0.091 12.6 0.0 0.39 10.5 0.0 2.1 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Esterase PF00756.20 ACT02914.1 - 1.7e-14 54.1 0.0 5.2e-14 52.5 0.0 1.7 2 0 0 2 2 2 1 Putative esterase adh_short PF00106.25 ACT02915.1 - 6.2e-45 153.1 0.0 1.2e-44 152.1 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT02915.1 - 7.5e-30 104.2 0.0 1.2e-29 103.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT02915.1 - 4.3e-07 30.0 0.0 8.6e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 ACT02915.1 - 0.023 15.3 0.6 0.045 14.3 0.6 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Alpha_L_fucos PF01120.17 ACT02916.1 - 9.2e-102 341.1 1.9 1.2e-101 340.7 1.9 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 ACT02916.1 - 8.4e-06 26.3 0.0 1.5e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain GHL6 PF14871.6 ACT02916.1 - 0.064 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 HTH_18 PF12833.7 ACT02917.1 - 1.6e-20 73.2 0.4 2.5e-20 72.5 0.4 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT02917.1 - 5.7e-13 48.6 0.1 2.7e-07 30.5 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT02917.1 - 4e-08 33.2 0.1 7.6e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT02917.1 - 1.6e-07 31.0 0.0 2.8e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Ectoine_synth PF06339.12 ACT02917.1 - 0.016 15.4 0.1 0.25 11.5 0.0 2.4 2 1 0 2 2 2 0 Ectoine synthase adh_short PF00106.25 ACT02918.1 - 5.5e-56 189.1 2.4 7.3e-56 188.7 2.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT02918.1 - 7.3e-40 137.0 2.2 1e-39 136.5 2.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT02918.1 - 6.5e-16 58.8 0.4 7.9e-16 58.5 0.4 1.1 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 ACT02918.1 - 0.00032 21.0 0.3 0.00063 20.0 0.3 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 ACT02918.1 - 0.031 14.7 0.4 0.19 12.2 0.2 2.1 2 0 0 2 2 2 0 Putative NAD(P)-binding Epimerase PF01370.21 ACT02918.1 - 0.032 13.7 0.9 0.064 12.7 0.2 2.0 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family YjeF_N PF03853.15 ACT02918.1 - 0.04 13.8 0.1 0.059 13.2 0.1 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus Sigma70_r4 PF04545.16 ACT02919.1 - 8.1e-18 63.7 2.0 1.7e-17 62.6 0.9 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACT02919.1 - 2.4e-13 49.7 0.0 7.5e-13 48.0 0.0 1.8 2 0 0 2 2 2 1 Sigma-70 region 2 HTH_3 PF01381.22 ACT02919.1 - 4.6e-06 26.6 0.3 1e-05 25.5 0.3 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_23 PF13384.6 ACT02919.1 - 4.6e-06 26.3 0.1 1.6e-05 24.6 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain MarR_2 PF12802.7 ACT02919.1 - 2e-05 24.4 0.0 4.2e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_19 PF12844.7 ACT02919.1 - 0.00035 20.5 0.6 0.0014 18.6 0.1 2.3 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_24 PF13412.6 ACT02919.1 - 0.0011 18.5 0.0 0.0025 17.3 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 ACT02919.1 - 0.0012 18.9 0.0 0.0029 17.7 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ACT02919.1 - 0.0013 19.1 0.0 0.0021 18.4 0.0 1.6 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 ACT02919.1 - 0.002 18.1 0.0 0.0061 16.5 0.0 1.8 2 0 0 2 2 1 1 Winged helix-turn helix KORA PF16509.5 ACT02919.1 - 0.0029 17.9 0.0 0.0046 17.2 0.0 1.5 1 0 0 1 1 1 1 TrfB plasmid transcriptional repressor HTH_5 PF01022.20 ACT02919.1 - 0.0089 15.9 0.2 0.36 10.7 0.0 2.8 3 0 0 3 3 3 1 Bacterial regulatory protein, arsR family TrmB PF01978.19 ACT02919.1 - 0.012 15.5 0.2 1.6 8.7 0.0 2.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_38 PF13936.6 ACT02919.1 - 0.015 15.1 0.5 0.029 14.1 0.5 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_25 PF13413.6 ACT02919.1 - 0.024 14.5 0.1 0.071 13.0 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain GerE PF00196.19 ACT02919.1 - 0.028 14.0 0.1 0.53 9.9 0.0 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_Crp_2 PF13545.6 ACT02919.1 - 0.032 14.2 0.0 0.068 13.1 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Sigma70_r4_2 PF08281.12 ACT02919.1 - 0.038 13.7 1.0 0.14 11.9 1.0 2.0 1 1 0 1 1 1 0 Sigma-70, region 4 HTH_10 PF04967.12 ACT02919.1 - 0.045 13.6 0.1 0.095 12.5 0.1 1.6 1 0 0 1 1 1 0 HTH DNA binding domain Trp_repressor PF01371.19 ACT02919.1 - 0.06 13.5 0.4 0.16 12.1 0.3 1.9 1 1 1 2 2 2 0 Trp repressor protein HTH_37 PF13744.6 ACT02919.1 - 0.063 13.2 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain KorB PF08535.10 ACT02919.1 - 0.068 13.2 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 KorB domain DUF3323 PF11796.8 ACT02920.1 - 1.3e-30 106.9 0.0 1.8e-30 106.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function N-terminus (DUF3323) DUF2399 PF09664.10 ACT02920.1 - 2.9e-29 101.9 0.0 4.4e-29 101.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2399) DUF2220 PF09983.9 ACT02920.1 - 6.3e-07 28.9 0.0 2.2e-06 27.2 0.0 1.9 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria C-term(DUF2220) SbcCD_C PF13558.6 ACT02921.1 - 5.4e-23 81.0 0.0 1.2e-22 79.9 0.0 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 ACT02921.1 - 3e-06 26.8 0.0 0.0051 16.3 0.0 2.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT02921.1 - 0.033 13.9 0.0 0.075 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain CENP-L PF13092.6 ACT02921.1 - 0.082 13.1 0.0 0.31 11.2 0.0 2.0 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 DUF2398 PF09661.10 ACT02922.1 - 9.1e-87 291.6 1.6 1e-86 291.5 1.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2398) DUF2397 PF09660.10 ACT02923.1 - 9.3e-125 417.3 0.8 1.1e-124 417.1 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2397) SPATA1_C PF15743.5 ACT02923.1 - 0.012 15.7 0.8 0.033 14.3 0.8 1.7 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus DUF4441 PF14536.6 ACT02923.1 - 0.74 10.0 6.4 0.18 12.0 1.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4441) S_4TM PF18159.1 ACT02925.1 - 1.5e-26 93.4 2.5 1.6e-26 93.3 2.5 1.0 1 0 0 1 1 1 1 SMODS-associating 4TM effector domain HTH_17 PF12728.7 ACT02926.1 - 0.00029 21.0 0.0 0.00076 19.6 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 ACT02926.1 - 0.0056 16.7 0.1 0.016 15.2 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix HTH_11 PF08279.12 ACT02926.1 - 0.0098 15.8 0.0 0.027 14.4 0.0 1.8 1 0 0 1 1 1 1 HTH domain Sigma70_r4_2 PF08281.12 ACT02926.1 - 0.017 14.7 0.0 0.061 13.0 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 NUMOD1 PF07453.13 ACT02926.1 - 0.034 14.4 0.0 0.11 12.7 0.0 1.9 1 0 0 1 1 1 0 NUMOD1 domain HTH_23 PF13384.6 ACT02926.1 - 0.046 13.5 0.0 0.19 11.6 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain AbiEi_4 PF13338.6 ACT02926.1 - 0.13 12.4 0.0 0.4 10.9 0.0 1.8 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin MerR PF00376.23 ACT02926.1 - 0.18 11.6 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 MerR family regulatory protein AAA_19 PF13245.6 ACT02928.1 - 7.9e-18 65.2 0.0 1.7e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 ACT02928.1 - 5.9e-16 58.9 9.7 4.2e-08 33.1 0.5 3.4 2 2 1 3 3 3 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ACT02928.1 - 4.5e-09 36.1 1.6 3.9e-08 33.1 0.1 2.5 3 0 0 3 3 3 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 ACT02928.1 - 7.9e-06 25.8 0.0 2.1 8.0 0.0 3.6 3 1 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 ACT02928.1 - 0.00033 20.4 0.0 0.00099 18.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 ACT02928.1 - 0.0012 18.7 0.0 0.055 13.3 0.0 2.5 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain ResIII PF04851.15 ACT02928.1 - 0.094 12.7 1.0 0.35 10.8 0.2 2.2 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_15 PF13175.6 ACT02929.1 - 7.3e-53 180.6 1.4 7.3e-53 180.6 1.4 2.2 2 2 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 ACT02929.1 - 6.1e-17 62.4 0.1 3.8e-10 40.1 0.1 3.1 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ACT02929.1 - 2.6e-09 37.9 1.7 9.3e-09 36.1 1.7 1.9 1 1 0 1 1 1 1 AAA domain DUF2813 PF11398.8 ACT02929.1 - 1.4e-06 27.8 0.3 0.0078 15.5 0.0 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF2813) SMC_N PF02463.19 ACT02929.1 - 2.3e-06 27.2 0.1 1e-05 25.1 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_27 PF13514.6 ACT02929.1 - 0.0033 17.0 0.0 0.007 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT02929.1 - 0.013 15.3 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 ACT02929.1 - 0.062 12.7 0.0 1.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 ACT02929.1 - 0.062 13.8 0.0 0.14 12.7 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Sigma70_r4 PF04545.16 ACT02930.1 - 2.4e-17 62.2 2.7 2.7e-17 62.0 0.9 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACT02930.1 - 2.9e-17 62.2 0.0 7.7e-17 60.8 0.0 1.7 2 0 0 2 2 2 1 Sigma-70 region 2 HTH_23 PF13384.6 ACT02930.1 - 2.5e-06 27.1 0.0 2.2e-05 24.1 0.1 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_3 PF01381.22 ACT02930.1 - 6.4e-06 26.1 0.3 1.4e-05 25.1 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix MarR_2 PF12802.7 ACT02930.1 - 2.8e-05 23.9 0.0 6e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_19 PF12844.7 ACT02930.1 - 0.00045 20.2 0.5 0.002 18.1 0.1 2.3 3 0 0 3 3 2 1 Helix-turn-helix domain HTH_28 PF13518.6 ACT02930.1 - 0.0007 19.7 0.0 0.0041 17.2 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 ACT02930.1 - 0.0015 18.5 0.1 0.0095 15.9 0.0 2.3 3 0 0 3 3 2 1 Winged helix-turn helix HTH_24 PF13412.6 ACT02930.1 - 0.0015 18.1 0.0 0.0035 16.9 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_31 PF13560.6 ACT02930.1 - 0.002 18.4 0.1 0.0033 17.7 0.1 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain KORA PF16509.5 ACT02930.1 - 0.0033 17.7 0.0 0.0069 16.6 0.0 1.7 1 0 0 1 1 1 1 TrfB plasmid transcriptional repressor GerE PF00196.19 ACT02930.1 - 0.013 15.0 0.1 0.72 9.4 0.0 2.9 3 0 0 3 3 3 0 Bacterial regulatory proteins, luxR family HTH_5 PF01022.20 ACT02930.1 - 0.015 15.2 0.2 0.49 10.3 0.0 3.0 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family HTH_38 PF13936.6 ACT02930.1 - 0.018 14.8 0.5 0.04 13.7 0.5 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain TrmB PF01978.19 ACT02930.1 - 0.019 14.8 0.2 2.2 8.2 0.0 2.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_25 PF13413.6 ACT02930.1 - 0.032 14.1 0.1 0.1 12.5 0.1 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT02930.1 - 0.044 13.8 0.0 0.097 12.7 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Sigma70_r4_2 PF08281.12 ACT02930.1 - 0.056 13.1 0.9 0.19 11.4 0.9 2.0 1 1 0 1 1 1 0 Sigma-70, region 4 HTH_10 PF04967.12 ACT02930.1 - 0.062 13.1 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 HTH DNA binding domain Trp_repressor PF01371.19 ACT02930.1 - 0.08 13.1 0.3 0.24 11.5 0.3 2.0 1 1 1 2 2 2 0 Trp repressor protein KorB PF08535.10 ACT02930.1 - 0.091 12.8 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 KorB domain HTH_37 PF13744.6 ACT02930.1 - 0.095 12.7 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Cu_amine_oxidN1 PF07833.11 ACT02931.1 - 1.7e-19 70.1 1.9 5.8e-16 58.8 0.7 3.2 2 2 1 3 3 3 2 Copper amine oxidase N-terminal domain Nramp PF01566.18 ACT02933.1 - 4.5e-137 456.8 25.7 4.5e-137 456.8 25.7 1.3 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein Hydrolase_2 PF07486.12 ACT02934.1 - 4.1e-27 95.1 0.0 7.5e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 Cell Wall Hydrolase PG_binding_1 PF01471.18 ACT02934.1 - 5.2e-15 55.4 0.0 8.3e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Putative peptidoglycan binding domain PG_binding_2 PF08823.11 ACT02934.1 - 0.017 15.4 0.1 0.031 14.6 0.1 1.4 1 0 0 1 1 1 0 Putative peptidoglycan binding domain WW PF00397.26 ACT02934.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 WW domain QueF PF14489.6 ACT02935.1 - 2.3e-35 120.6 0.0 3.1e-35 120.2 0.0 1.2 1 0 0 1 1 1 1 QueF-like protein QueF_N PF14819.6 ACT02935.1 - 0.0001 22.6 0.0 0.00017 21.9 0.0 1.5 1 1 0 1 1 1 1 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term TF_Otx PF03529.13 ACT02935.1 - 0.069 13.6 0.0 0.1 13.0 0.0 1.2 1 0 0 1 1 1 0 Otx1 transcription factor Radical_SAM PF04055.21 ACT02936.1 - 5.1e-15 56.3 0.0 3.6e-14 53.5 0.0 2.1 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 ACT02936.1 - 2.1e-09 37.6 0.0 4.4e-09 36.5 0.0 1.5 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 ACT02936.1 - 6.2e-09 36.3 0.0 1.1e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain PTPS PF01242.19 ACT02937.1 - 1.7e-27 95.8 0.1 2.1e-27 95.5 0.1 1.1 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase HyaE PF07449.11 ACT02937.1 - 0.16 12.0 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE MYEOV2 PF15004.6 ACT02937.1 - 0.17 12.3 2.2 0.28 11.6 2.2 1.3 1 0 0 1 1 1 0 Myeloma-overexpressed-like QueC PF06508.13 ACT02938.1 - 6.3e-85 284.0 0.0 7.1e-85 283.8 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 ACT02938.1 - 2e-07 30.8 0.0 7.8e-07 28.9 0.0 1.9 1 1 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Asn_synthase PF00733.21 ACT02938.1 - 0.0002 21.2 0.0 0.00026 20.8 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase Arginosuc_synth PF00764.19 ACT02938.1 - 0.00049 19.5 0.0 0.0007 19.0 0.0 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase Diphthami_syn_2 PF01902.17 ACT02938.1 - 0.00082 18.9 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Diphthamide synthase ATP_bind_3 PF01171.20 ACT02938.1 - 0.0011 18.8 0.0 0.0016 18.3 0.0 1.2 1 0 0 1 1 1 1 PP-loop family NAD_synthase PF02540.17 ACT02938.1 - 0.012 14.7 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 NAD synthase tRNA_Me_trans PF03054.16 ACT02938.1 - 0.082 11.7 0.0 0.098 11.4 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase PAPS_reduct PF01507.19 ACT02938.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family zf-RING_4 PF14570.6 ACT02938.1 - 0.52 10.2 3.8 0.19 11.6 0.9 1.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Oxidored_molyb PF00174.19 ACT02939.1 - 6.8e-39 133.2 0.1 8.8e-39 132.9 0.1 1.1 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain SLH PF00395.20 ACT02940.1 - 0.048 13.7 0.0 3.5 7.7 0.0 2.9 2 0 0 2 2 2 0 S-layer homology domain DUF2634 PF10934.8 ACT02940.1 - 0.17 12.0 1.2 7.9 6.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2634) SLH PF00395.20 ACT02941.1 - 3.2e-40 135.9 0.3 1.8e-14 53.4 0.0 4.0 3 0 0 3 3 3 3 S-layer homology domain Cohesin PF00963.18 ACT02941.1 - 3e-18 66.4 15.0 2e-12 47.5 0.6 3.4 3 1 2 5 5 5 2 Cohesin domain Dockerin_1 PF00404.18 ACT02942.1 - 8.2e-11 41.9 3.9 2.9e-09 37.0 4.2 2.4 2 0 0 2 2 2 1 Dockerin type I domain PhoH PF02562.16 ACT02942.1 - 0.0025 17.3 4.7 0.35 10.3 0.2 2.5 3 0 0 3 3 3 2 PhoH-like protein AAA PF00004.29 ACT02942.1 - 0.032 14.7 3.3 1.3 9.4 0.2 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 ACT02942.1 - 0.048 12.9 0.9 3.1 6.9 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 ACT02942.1 - 0.12 11.7 1.0 2.5 7.4 0.1 2.2 2 0 0 2 2 2 0 KaiC Neuraminidase PF18413.1 ACT02943.1 - 0.0012 18.6 3.8 0.21 11.3 0.0 3.5 1 1 3 4 4 4 3 Neuraminidase-like domain MarR PF01047.22 ACT02944.1 - 2.2e-13 49.9 0.0 4.6e-13 48.9 0.0 1.6 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 ACT02944.1 - 8.5e-08 32.6 0.0 1.9e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR_2 PF12802.7 ACT02944.1 - 2.9e-07 30.3 0.0 4.6e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.6 ACT02944.1 - 2.2e-05 24.5 0.0 5.8e-05 23.2 0.0 1.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain TrmB PF01978.19 ACT02944.1 - 0.0012 18.6 0.0 0.0027 17.6 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB UreD PF01774.17 ACT02945.1 - 1.2e-34 120.1 0.0 1.4e-34 119.8 0.0 1.0 1 0 0 1 1 1 1 UreD urease accessory protein Kp4 PF09044.10 ACT02945.1 - 0.034 14.2 0.0 0.055 13.5 0.0 1.3 1 0 0 1 1 1 0 Kp4 cobW PF02492.19 ACT02946.1 - 1.1e-39 135.9 0.0 1.3e-39 135.6 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 ACT02946.1 - 0.00057 20.4 0.0 0.00092 19.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 ACT02946.1 - 0.0006 18.9 0.0 0.1 11.6 0.0 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 ACT02946.1 - 0.0033 16.7 0.0 0.0052 16.1 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 ACT02946.1 - 0.0038 17.6 0.0 0.0052 17.2 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ACT02946.1 - 0.01 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MobB PF03205.14 ACT02946.1 - 0.016 15.1 0.0 0.5 10.3 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.6 ACT02946.1 - 0.061 13.5 0.0 0.098 12.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ACT02946.1 - 0.073 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 ACT02946.1 - 0.082 12.1 0.0 0.082 12.1 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain RNA_helicase PF00910.22 ACT02946.1 - 0.084 13.3 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 RNA helicase dNK PF01712.19 ACT02946.1 - 0.088 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Deoxynucleoside kinase ABC_tran PF00005.27 ACT02946.1 - 0.1 13.1 0.0 0.15 12.6 0.0 1.2 1 0 0 1 1 1 0 ABC transporter NTPase_1 PF03266.15 ACT02946.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 NTPase GTP_EFTU PF00009.27 ACT02946.1 - 0.13 11.8 0.1 2.1 7.8 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 ACT02946.1 - 0.15 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region TIP49 PF06068.13 ACT02946.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain UreF PF01730.16 ACT02947.1 - 1.1e-27 97.2 3.2 1.5e-27 96.8 3.2 1.2 1 0 0 1 1 1 1 UreF DUF3239 PF11580.8 ACT02947.1 - 0.013 15.8 0.1 0.033 14.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3239) GATase_6 PF13522.6 ACT02947.1 - 0.082 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Glutamine amidotransferase domain Amidohydro_1 PF01979.20 ACT02948.1 - 6e-80 269.1 0.6 8.7e-80 268.6 0.6 1.2 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 ACT02948.1 - 2.1e-56 189.5 2.9 4.5e-56 188.4 2.9 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Amidohydro_3 PF07969.11 ACT02948.1 - 9e-10 38.6 3.7 3.3e-05 23.5 0.1 3.2 2 1 1 3 3 3 2 Amidohydrolase family DUF4088 PF13317.6 ACT02948.1 - 0.06 12.9 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) Molybdopterin_N PF18364.1 ACT02948.1 - 0.17 11.9 0.9 30 4.7 0.8 2.6 2 0 0 2 2 2 0 Molybdopterin oxidoreductase N-terminal domain Urease_beta PF00699.20 ACT02949.1 - 9.9e-42 140.9 0.0 1.2e-41 140.7 0.0 1.0 1 0 0 1 1 1 1 Urease beta subunit Urease_gamma PF00547.18 ACT02950.1 - 2.3e-47 159.4 0.4 2.5e-47 159.2 0.4 1.0 1 0 0 1 1 1 1 Urease, gamma subunit dsDNA_bind PF01984.20 ACT02950.1 - 0.031 14.5 0.4 0.038 14.3 0.4 1.2 1 0 0 1 1 1 0 Double-stranded DNA-binding domain Svf1_C PF17187.4 ACT02950.1 - 0.048 13.5 0.0 0.054 13.3 0.0 1.1 1 0 0 1 1 1 0 Svf1-like C-terminal lipocalin-like domain Herpes_UL36 PF03586.13 ACT02950.1 - 0.14 11.5 0.0 4.4 6.5 0.0 2.0 1 1 1 2 2 2 0 Herpesvirus UL36 tegument protein BPD_transp_2 PF02653.16 ACT02951.1 - 1.1e-45 155.9 30.4 1.1e-45 155.9 30.4 2.0 2 0 0 2 2 2 2 Branched-chain amino acid transport system / permease component DUF1427 PF07235.11 ACT02951.1 - 0.76 9.8 4.7 2.3 8.2 4.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1427) ABC_tran PF00005.27 ACT02952.1 - 1.6e-49 168.0 0.0 1.1e-26 94.0 0.0 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACT02952.1 - 8e-10 39.0 0.6 0.0033 17.3 0.0 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT02952.1 - 0.00017 21.1 0.2 0.0015 18.0 0.2 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT02952.1 - 0.00063 19.4 0.0 0.0015 18.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_10 PF12846.7 ACT02952.1 - 0.0036 16.3 0.0 0.0069 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain AAA_23 PF13476.6 ACT02952.1 - 0.0042 17.6 0.1 0.01 16.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT02952.1 - 0.015 15.2 0.0 0.044 13.7 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase MukB PF04310.12 ACT02952.1 - 0.031 14.1 0.0 0.075 12.8 0.0 1.6 1 0 0 1 1 1 0 MukB N-terminal AAA_15 PF13175.6 ACT02952.1 - 0.058 13.1 0.0 0.42 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ACT02952.1 - 0.11 12.8 0.0 0.46 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 ACT02952.1 - 0.13 10.9 0.1 8.6 4.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ACT02952.1 - 0.14 12.5 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ABC_ATPase PF09818.9 ACT02952.1 - 0.18 10.5 4.7 6 5.5 0.1 3.5 3 1 0 3 3 3 0 Predicted ATPase of the ABC class Peripla_BP_4 PF13407.6 ACT02953.1 - 2e-58 198.0 13.6 2.4e-58 197.8 13.6 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACT02953.1 - 7.6e-09 35.4 3.9 4.1e-08 33.0 3.9 1.9 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 ACT02953.1 - 3e-06 27.7 0.0 5.8e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_4 PF13407.6 ACT02954.1 - 4.2e-50 170.7 4.3 5.3e-50 170.4 4.3 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACT02954.1 - 1.1e-17 64.4 1.1 1.4e-17 64.1 1.1 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_6 PF13458.6 ACT02954.1 - 2.3e-06 27.5 7.5 0.00027 20.7 0.5 2.1 1 1 1 2 2 2 2 Periplasmic binding protein Peripla_BP_3 PF13377.6 ACT02954.1 - 2.5e-06 27.9 1.8 0.016 15.5 0.1 2.2 1 1 1 2 2 2 2 Periplasmic binding protein-like domain ANF_receptor PF01094.28 ACT02954.1 - 0.00092 18.4 0.0 0.01 15.0 0.0 1.9 1 1 1 2 2 2 1 Receptor family ligand binding region Glycos_transf_N PF04413.16 ACT02954.1 - 0.017 14.8 0.0 0.033 13.8 0.0 1.6 1 0 0 1 1 1 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) ABC_sub_bind PF04392.12 ACT02954.1 - 0.021 14.1 0.1 0.047 12.9 0.0 1.5 2 0 0 2 2 2 0 ABC transporter substrate binding protein NYN PF01936.18 ACT02954.1 - 0.023 15.2 0.1 0.082 13.4 0.1 1.9 1 1 1 2 2 2 0 NYN domain Ribosomal_S2 PF00318.20 ACT02954.1 - 0.082 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S2 His_kinase PF06580.13 ACT02955.1 - 5.6e-27 93.9 1.0 5.6e-27 93.9 1.0 2.5 3 0 0 3 3 3 1 Histidine kinase dCache_1 PF02743.18 ACT02955.1 - 1.1e-24 87.6 3.7 1.1e-24 87.6 3.7 1.9 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACT02955.1 - 6.8e-14 52.3 0.1 1.9e-13 50.9 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT02955.1 - 3.2e-09 37.0 0.0 7.8e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 HAMP domain Cache_3-Cache_2 PF17201.4 ACT02955.1 - 5.2e-08 32.5 4.8 3.4e-07 29.8 0.2 2.6 2 0 0 2 2 2 1 Cache 3/Cache 2 fusion domain HATPase_c_2 PF13581.6 ACT02955.1 - 0.026 14.5 0.0 0.072 13.1 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Response_reg PF00072.24 ACT02956.1 - 6.6e-26 90.7 0.0 1.5e-25 89.5 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT02956.1 - 3.7e-19 68.3 0.1 5.2e-09 36.0 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT02956.1 - 8.4e-18 64.4 0.1 1.9e-17 63.3 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain GGDEF_2 PF17853.1 ACT02956.1 - 5.9e-11 42.7 0.0 1.2e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 GGDEF-like domain ILVD_EDD PF00920.21 ACT02957.1 - 3.6e-219 728.7 2.4 4.1e-219 728.5 2.4 1.0 1 0 0 1 1 1 1 Dehydratase family Polysacc_deac_1 PF01522.21 ACT02958.1 - 1.8e-28 98.9 0.1 5.7e-28 97.3 0.1 1.8 2 0 0 2 2 2 1 Polysaccharide deacetylase DUF2095 PF09868.9 ACT02958.1 - 0.19 11.7 0.0 17 5.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2095) AI-2E_transport PF01594.16 ACT02959.1 - 3.2e-17 62.7 16.9 4.2e-17 62.3 16.9 1.0 1 0 0 1 1 1 1 AI-2E family transporter H_PPase PF03030.16 ACT02959.1 - 7.8 5.0 8.1 1.3 7.6 3.5 2.0 1 1 0 1 1 1 0 Inorganic H+ pyrophosphatase Transpeptidase PF00905.22 ACT02960.1 - 2.6e-53 181.2 0.0 3.7e-53 180.7 0.0 1.2 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 ACT02960.1 - 1.2e-09 38.7 0.0 2.3e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Penicillin-binding Protein dimerisation domain Homeodomain PF00046.29 ACT02960.1 - 1.3 9.0 4.0 2.2 8.2 2.3 2.2 2 0 0 2 2 2 0 Homeodomain MCPsignal PF00015.21 ACT02961.1 - 3.9e-28 98.4 30.8 1.1e-27 96.9 11.2 4.0 1 1 2 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 ACT02961.1 - 1.2e-16 61.3 1.6 1.2e-16 61.3 1.6 2.9 3 1 1 4 4 4 1 Cache domain HAMP PF00672.25 ACT02961.1 - 2e-07 31.3 2.4 8.6e-07 29.2 0.2 3.1 3 0 0 3 3 3 1 HAMP domain DUF948 PF06103.11 ACT02961.1 - 0.018 15.2 29.0 0.093 13.0 1.6 6.7 3 2 3 6 6 6 0 Bacterial protein of unknown function (DUF948) Vps5 PF09325.10 ACT02961.1 - 0.023 14.2 5.1 0.096 12.2 1.4 2.7 2 0 0 2 2 2 0 Vps5 C terminal like CooC_C PF15976.5 ACT02961.1 - 0.038 14.0 0.7 0.21 11.7 0.7 2.4 1 0 0 1 1 1 0 CS1-pili formation C-terminal Lipoprotein_20 PF13942.6 ACT02961.1 - 0.18 11.7 1.2 1.4 8.8 0.0 2.7 2 1 2 4 4 4 0 YfhG lipoprotein ATG16 PF08614.11 ACT02961.1 - 0.18 12.0 9.3 0.46 10.7 1.1 2.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF1043 PF06295.12 ACT02961.1 - 1 9.4 6.4 0.33 11.0 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1043) NPV_P10 PF05531.12 ACT02961.1 - 1.1 9.7 19.5 1.7 9.1 0.7 4.6 4 1 1 5 5 4 0 Nucleopolyhedrovirus P10 protein Matrilin_ccoil PF10393.9 ACT02961.1 - 2.1 8.3 4.3 45 4.0 0.1 3.6 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF5471 PF17565.2 ACT02961.1 - 3.6 7.9 5.7 5.6 7.3 0.5 3.0 3 0 0 3 3 2 0 Family of unknown function (DUF5471) I_LWEQ PF01608.17 ACT02961.1 - 7.8 6.7 19.3 0.13 12.5 5.6 3.5 3 2 2 5 5 5 0 I/LWEQ domain YceG PF02618.16 ACT02962.1 - 8.1e-94 314.2 0.0 9.4e-94 314.0 0.0 1.0 1 0 0 1 1 1 1 YceG-like family DUF1292 PF06949.11 ACT02964.1 - 4.5e-12 46.7 1.6 6e-12 46.3 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1292) DUF1292 PF06949.11 ACT02965.1 - 1.1e-18 68.0 14.0 1.5e-18 67.5 14.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1292) RuvX PF03652.15 ACT02966.1 - 4.1e-46 156.7 0.1 4.5e-46 156.6 0.1 1.0 1 0 0 1 1 1 1 Holliday junction resolvase IreB PF06135.12 ACT02967.1 - 9.9e-36 121.8 0.1 1.1e-35 121.6 0.1 1.0 1 0 0 1 1 1 1 IreB regulatory phosphoprotein tRNA-synt_2c PF01411.19 ACT02968.1 - 2.6e-209 696.3 0.0 3.5e-209 695.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) DHHA1 PF02272.19 ACT02968.1 - 1.9e-28 99.6 7.2 2.9e-28 99.0 5.6 2.1 2 0 0 2 2 2 1 DHHA1 domain tRNA_SAD PF07973.14 ACT02968.1 - 4.3e-19 68.3 1.1 1e-18 67.1 1.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Leu_zip PF15294.6 ACT02968.1 - 0.17 11.4 2.1 0.16 11.5 0.3 1.7 2 0 0 2 2 2 0 Leucine zipper H-kinase_dim PF02895.14 ACT02968.1 - 2.2 8.7 5.5 8.6 6.8 0.2 3.2 3 0 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain DeoRC PF00455.22 ACT02970.1 - 1e-43 149.1 0.0 1.3e-43 148.7 0.0 1.2 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 ACT02970.1 - 9.3e-15 54.1 0.2 2e-14 53.1 0.2 1.5 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACT02970.1 - 1.3e-05 25.1 0.2 3.4e-05 23.7 0.2 1.7 1 0 0 1 1 1 1 HTH domain FaeA PF04703.12 ACT02970.1 - 6.3e-05 23.3 0.0 0.00012 22.3 0.0 1.5 1 0 0 1 1 1 1 FaeA-like protein HTH_24 PF13412.6 ACT02970.1 - 0.0003 20.3 0.5 0.00054 19.5 0.5 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding GntR PF00392.21 ACT02970.1 - 0.0065 16.1 0.0 0.017 14.8 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family TFIIE_alpha PF02002.17 ACT02970.1 - 0.029 14.2 0.3 0.06 13.2 0.3 1.5 1 0 0 1 1 1 0 TFIIE alpha subunit DUF5097 PF17020.5 ACT02970.1 - 0.053 13.9 1.8 11 6.4 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF5097) HTH_36 PF13730.6 ACT02970.1 - 0.08 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CitX PF03802.14 ACT02970.1 - 0.086 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase MarR PF01047.22 ACT02970.1 - 0.12 12.4 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 MarR family Glycos_transf_2 PF00535.26 ACT02970.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 FeoC PF09012.10 ACT02970.1 - 0.15 12.1 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_Tnp_Tc3_2 PF01498.18 ACT02970.1 - 0.18 12.1 0.1 0.33 11.2 0.1 1.4 1 0 0 1 1 1 0 Transposase Aminotran_5 PF00266.19 ACT02971.1 - 7.7e-26 90.9 0.0 9.4e-26 90.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ACT02971.1 - 2.6e-05 22.9 0.1 3.8e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF5486 PF17588.2 ACT02971.1 - 0.088 12.7 0.0 7.7 6.5 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5486) HAD_2 PF13419.6 ACT02972.1 - 1.4e-07 31.8 0.0 2.8e-07 30.8 0.0 1.4 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT02972.1 - 1.3e-06 28.8 0.0 2.4e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT02972.1 - 0.025 14.7 0.0 0.066 13.3 0.0 1.9 1 1 0 1 1 1 0 HAD-hyrolase-like BPD_transp_1 PF00528.22 ACT02973.1 - 1.1e-22 80.7 53.2 1.1e-13 51.4 18.6 3.9 2 2 2 4 4 4 2 Binding-protein-dependent transport system inner membrane component DUF4064 PF13273.6 ACT02973.1 - 0.38 11.1 31.5 0.044 14.1 2.2 5.3 3 1 1 4 4 4 0 Protein of unknown function (DUF4064) ABC_tran PF00005.27 ACT02974.1 - 2.3e-34 118.9 0.0 3.7e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02974.1 - 1.6e-08 34.8 0.1 0.0012 18.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT02974.1 - 1.3e-07 31.3 0.3 6.8e-05 22.4 0.5 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain TOBE_2 PF08402.10 ACT02974.1 - 1.1e-06 28.7 0.1 6e-06 26.3 0.1 2.4 2 1 0 2 2 2 1 TOBE domain AAA_23 PF13476.6 ACT02974.1 - 0.00037 21.1 0.5 0.00078 20.0 0.1 1.7 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.6 ACT02974.1 - 0.00039 20.9 0.1 0.00073 20.0 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 ACT02974.1 - 0.00044 19.2 0.3 0.0052 15.6 0.2 2.6 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA PF00004.29 ACT02974.1 - 0.0018 18.7 0.9 0.0094 16.4 0.9 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ACT02974.1 - 0.0065 16.4 0.0 0.015 15.2 0.0 1.6 2 0 0 2 2 1 1 RsgA GTPase NACHT PF05729.12 ACT02974.1 - 0.0073 16.2 0.1 0.015 15.2 0.1 1.5 1 0 0 1 1 1 1 NACHT domain ATPase PF06745.13 ACT02974.1 - 0.0088 15.4 0.1 2.7 7.3 0.1 2.3 2 0 0 2 2 2 1 KaiC AAA_22 PF13401.6 ACT02974.1 - 0.0097 16.2 0.5 0.028 14.7 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ACT02974.1 - 0.011 15.7 0.7 0.028 14.4 0.1 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 ACT02974.1 - 0.013 15.7 0.2 0.04 14.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ACT02974.1 - 0.014 14.8 0.1 0.064 12.6 0.0 2.0 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ACT02974.1 - 0.015 14.9 0.0 0.095 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 ACT02974.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 ACT02974.1 - 0.026 14.3 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PhoH PF02562.16 ACT02974.1 - 0.028 13.9 0.0 0.57 9.6 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_18 PF13238.6 ACT02974.1 - 0.028 14.9 0.0 0.092 13.3 0.0 1.9 3 0 0 3 3 1 0 AAA domain AAA_24 PF13479.6 ACT02974.1 - 0.031 14.0 0.5 0.39 10.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 ACT02974.1 - 0.038 13.7 0.0 0.25 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ACT02974.1 - 0.041 13.8 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DLIC PF05783.11 ACT02974.1 - 0.045 12.6 0.0 0.071 11.9 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_15 PF13175.6 ACT02974.1 - 0.052 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 ACT02974.1 - 0.06 13.1 0.0 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation UDPG_MGDP_dh_C PF03720.15 ACT02974.1 - 0.067 13.6 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain FeoB_N PF02421.18 ACT02974.1 - 0.073 12.6 0.1 9.8 5.7 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B TsaE PF02367.17 ACT02974.1 - 0.12 12.4 0.0 0.34 10.9 0.0 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ACT02974.1 - 0.16 12.1 0.2 0.43 10.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain SBP_bac_6 PF13343.6 ACT02975.1 - 3.8e-31 108.4 2.0 5.4e-31 107.9 0.8 1.7 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT02975.1 - 6.9e-24 85.1 6.2 9.4e-24 84.7 6.2 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT02975.1 - 2.6e-12 47.0 0.1 8.1e-12 45.4 0.1 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT02975.1 - 1.2e-11 45.1 8.5 1.7e-11 44.6 8.5 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein zf-RRPl_C4 PF17026.5 ACT02976.1 - 0.0033 17.5 0.1 0.0037 17.4 0.1 1.1 1 0 0 1 1 1 1 Putative ribonucleoprotein zinc-finger pf C4 type RPA_interact_C PF14768.6 ACT02976.1 - 0.077 13.6 0.1 0.086 13.4 0.1 1.1 1 0 0 1 1 1 0 Replication protein A interacting C-terminal zf-RING_7 PF02591.15 ACT02976.1 - 0.081 13.1 1.7 5.7 7.2 0.3 2.3 2 0 0 2 2 2 0 C4-type zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 ACT02976.1 - 0.18 11.8 2.2 0.29 11.2 2.2 1.2 1 0 0 1 1 1 0 Transposase zinc-ribbon domain PRC PF05239.16 ACT02977.1 - 6.6e-13 48.6 0.3 2.2e-05 24.5 0.1 2.2 2 0 0 2 2 2 2 PRC-barrel domain MlaD PF02470.20 ACT02977.1 - 0.04 14.2 0.0 0.13 12.6 0.0 1.8 2 0 0 2 2 2 0 MlaD protein Aminotran_5 PF00266.19 ACT02978.1 - 7.1e-80 268.7 0.6 9.3e-80 268.3 0.6 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ACT02978.1 - 3e-09 36.6 0.2 4.5e-09 36.0 0.2 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ACT02978.1 - 2.4e-07 30.4 1.6 4.3e-07 29.6 1.6 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ACT02978.1 - 0.0015 17.1 0.1 0.0028 16.2 0.0 1.4 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.19 ACT02978.1 - 0.0026 16.5 0.2 0.0042 15.9 0.2 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Glyoxalase PF00903.25 ACT02978.1 - 0.076 13.2 0.1 1.1 9.5 0.1 2.4 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Rrf2 PF02082.20 ACT02979.1 - 6.7e-28 96.9 0.1 9.5e-28 96.4 0.1 1.2 1 0 0 1 1 1 1 Transcriptional regulator MarR_2 PF12802.7 ACT02979.1 - 0.0022 17.9 0.0 0.0059 16.5 0.0 1.7 1 1 1 2 2 2 1 MarR family HrcA_DNA-bdg PF03444.15 ACT02979.1 - 0.012 15.2 0.1 0.019 14.6 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding tRNA_Me_trans PF03054.16 ACT02980.1 - 4.9e-146 486.1 0.0 5.7e-146 485.9 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 ACT02980.1 - 1.6e-07 30.7 0.0 9.4e-07 28.2 0.0 2.1 2 1 0 2 2 2 1 NAD synthase ATP_bind_3 PF01171.20 ACT02980.1 - 2e-05 24.4 0.0 4.1e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 PP-loop family Asn_synthase PF00733.21 ACT02980.1 - 0.00021 21.0 0.0 0.0003 20.6 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 ACT02980.1 - 0.00045 19.9 0.0 0.00071 19.2 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 ACT02980.1 - 0.0077 15.8 0.0 0.022 14.3 0.0 1.7 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC DUF21 PF01595.20 ACT02981.1 - 7.5e-52 175.6 3.7 1.1e-51 175.1 3.7 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CorC_HlyC PF03471.17 ACT02981.1 - 1.7e-16 60.0 1.3 2.5e-16 59.5 0.1 2.0 3 0 0 3 3 3 1 Transporter associated domain CBS PF00571.28 ACT02981.1 - 8.6e-10 38.9 1.5 0.00092 19.6 0.2 2.4 2 0 0 2 2 2 2 CBS domain CopC PF04234.12 ACT02982.1 - 8.1e-24 84.5 0.4 8.1e-24 84.5 0.4 2.0 2 0 0 2 2 2 1 CopC domain FlgD_ig PF13860.6 ACT02982.1 - 0.001 18.9 3.6 0.089 12.7 0.4 2.6 1 1 1 2 2 2 2 FlgD Ig-like domain Big_5 PF13205.6 ACT02982.1 - 0.0083 16.8 2.5 0.0083 16.8 2.5 1.6 1 1 1 2 2 2 1 Bacterial Ig-like domain Gmad2 PF10648.9 ACT02982.1 - 0.044 14.0 0.8 0.2 11.9 0.4 2.2 1 1 1 2 2 2 0 Immunoglobulin-like domain of bacterial spore germination Arch_flagellin PF01917.16 ACT02982.1 - 1.7 8.8 7.7 5.8 7.1 2.7 2.2 2 0 0 2 2 2 0 Archaebacterial flagellin CopD PF05425.13 ACT02983.1 - 6e-12 45.9 1.9 6e-12 45.9 1.9 3.8 4 1 0 4 4 4 1 Copper resistance protein D DUF2759 PF10958.8 ACT02983.1 - 0.00067 19.3 1.9 0.0026 17.4 1.9 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2759) ROK PF00480.20 ACT02984.1 - 1.6e-34 119.7 0.0 2.2e-34 119.3 0.0 1.1 1 0 0 1 1 1 1 ROK family HTH_5 PF01022.20 ACT02984.1 - 0.0015 18.4 0.1 0.0026 17.6 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 ACT02984.1 - 0.0018 17.8 0.4 0.004 16.7 0.4 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_45 PF14947.6 ACT02984.1 - 0.011 15.7 0.3 0.034 14.1 0.3 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DEDD_Tnp_IS110 PF01548.17 ACT02984.1 - 0.039 13.8 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 Transposase HTH_DeoR PF08220.12 ACT02984.1 - 0.074 12.8 0.6 0.17 11.6 0.3 1.8 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain ADH_N PF08240.12 ACT02985.1 - 1.1e-31 108.9 0.6 1.9e-31 108.2 0.6 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ACT02985.1 - 4.8e-19 68.6 0.0 8.6e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ACT02985.1 - 1.1e-06 28.3 0.0 0.00021 20.8 0.0 2.2 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ACT02985.1 - 0.00034 21.7 0.0 0.00088 20.3 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Peripla_BP_2 PF01497.18 ACT02986.1 - 1.7e-33 116.2 0.4 2.2e-33 115.8 0.4 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Oxidored_nitro PF00148.19 ACT02986.1 - 0.0026 16.6 0.0 0.0042 15.9 0.0 1.3 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase DUF4972 PF16342.5 ACT02986.1 - 0.03 14.0 0.8 0.26 11.0 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4972) MC1 PF05854.11 ACT02986.1 - 0.1 12.9 0.5 0.5 10.7 0.0 2.1 2 0 0 2 2 2 0 Non-histone chromosomal protein MC1 FecCD PF01032.18 ACT02987.1 - 4.8e-89 298.5 34.4 5.6e-89 298.2 34.4 1.0 1 0 0 1 1 1 1 FecCD transport family FecCD PF01032.18 ACT02988.1 - 1.1e-89 300.5 36.6 1.4e-89 300.2 36.6 1.0 1 0 0 1 1 1 1 FecCD transport family Consortin_C PF15281.6 ACT02988.1 - 0.21 11.6 0.2 1.2 9.2 0.0 2.0 2 0 0 2 2 2 0 Consortin C-terminus ABC_tran PF00005.27 ACT02989.1 - 5.7e-33 114.3 0.1 7.8e-33 113.9 0.1 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT02989.1 - 2.6e-11 43.9 1.1 2.5e-05 24.2 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT02989.1 - 1.2e-08 34.6 0.2 3.4e-07 29.9 0.2 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ACT02989.1 - 2.5e-08 34.0 0.1 1.9e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ACT02989.1 - 5.4e-07 29.3 0.1 1.1e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 ACT02989.1 - 2e-05 24.6 0.2 0.0025 17.8 0.1 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ACT02989.1 - 3.1e-05 24.4 0.3 7.6e-05 23.2 0.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 ACT02989.1 - 3.5e-05 23.3 0.2 0.0026 17.2 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 ACT02989.1 - 5.5e-05 23.8 0.2 0.00011 22.7 0.2 1.7 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 ACT02989.1 - 0.00024 20.0 0.4 0.012 14.5 0.1 2.2 2 0 0 2 2 2 1 Predicted ATPase of the ABC class DUF2813 PF11398.8 ACT02989.1 - 0.00027 20.3 0.0 0.00044 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2813) RsgA_GTPase PF03193.16 ACT02989.1 - 0.00088 19.2 0.2 0.0017 18.3 0.2 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_27 PF13514.6 ACT02989.1 - 0.0012 18.5 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 ACT02989.1 - 0.0031 17.4 1.0 0.012 15.6 0.3 2.1 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 ACT02989.1 - 0.007 16.6 0.5 0.029 14.6 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ACT02989.1 - 0.012 15.8 0.1 0.11 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.15 ACT02989.1 - 0.012 14.4 0.1 0.057 12.2 0.0 1.8 2 0 0 2 2 2 0 Adenovirus IVa2 protein Zeta_toxin PF06414.12 ACT02989.1 - 0.013 14.8 0.1 0.034 13.4 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 ACT02989.1 - 0.014 15.1 0.2 0.029 14.1 0.2 1.6 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 ACT02989.1 - 0.018 14.6 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 ACT02989.1 - 0.02 15.0 0.0 0.084 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 ACT02989.1 - 0.027 14.9 0.4 0.12 12.8 0.4 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ACT02989.1 - 0.034 14.1 1.4 0.065 13.1 0.2 2.0 2 1 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 ACT02989.1 - 0.041 14.1 0.7 0.078 13.2 0.1 1.7 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.6 ACT02989.1 - 0.062 12.9 0.4 0.15 11.6 0.1 1.7 2 1 0 2 2 2 0 AAA domain MukB PF04310.12 ACT02989.1 - 0.066 13.0 0.1 0.24 11.1 0.0 1.8 2 0 0 2 2 2 0 MukB N-terminal RNA_helicase PF00910.22 ACT02989.1 - 0.09 13.2 0.0 0.26 11.7 0.0 1.7 2 0 0 2 2 1 0 RNA helicase AAA_18 PF13238.6 ACT02989.1 - 0.095 13.3 0.1 0.49 10.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 ACT02989.1 - 0.11 11.6 0.1 0.2 10.8 0.1 1.3 1 0 0 1 1 1 0 G-protein alpha subunit ATPase_2 PF01637.18 ACT02989.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF815 PF05673.13 ACT02989.1 - 0.14 11.3 0.1 0.27 10.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) MMR_HSR1 PF01926.23 ACT02989.1 - 0.15 12.1 0.2 0.49 10.5 0.1 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase SPOB_a PF14689.6 ACT02990.1 - 2.7e-19 68.6 1.7 4.3e-19 68.0 0.6 1.9 2 0 0 2 2 2 1 Sensor_kinase_SpoOB-type, alpha-helical domain HATPase_c_5 PF14501.6 ACT02990.1 - 1.5e-17 63.3 0.4 3.7e-17 62.1 0.2 1.8 2 0 0 2 2 2 1 GHKL domain dCache_1 PF02743.18 ACT02990.1 - 2.7e-06 27.4 0.3 7.1e-06 26.0 0.3 1.7 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT02990.1 - 5.3e-06 26.9 0.0 9.8e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase sCache_3_2 PF17203.4 ACT02990.1 - 0.04 14.0 0.1 0.074 13.2 0.1 1.4 1 0 0 1 1 1 0 Single cache domain 3 NfeD PF01957.18 ACT02990.1 - 0.085 13.2 0.0 0.26 11.7 0.0 1.8 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding DUF3139 PF11337.8 ACT02990.1 - 3.6 8.3 5.6 70 4.2 0.2 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF3139) MgsA_C PF12002.8 ACT02991.1 - 2.6e-55 186.9 0.2 4.2e-55 186.2 0.2 1.3 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 ACT02991.1 - 9.2e-21 74.0 0.1 2.9e-20 72.4 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 ACT02991.1 - 1.4e-17 64.3 0.0 2.7e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ACT02991.1 - 1.5e-16 60.6 0.0 2.6e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 ACT02991.1 - 9.1e-09 35.2 0.0 1.4e-06 28.1 0.0 2.4 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 ACT02991.1 - 4.9e-08 33.1 0.0 1.7e-07 31.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ACT02991.1 - 8.1e-08 32.4 0.0 1.3e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT02991.1 - 1.6e-07 31.9 0.4 3.9e-05 24.1 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 ACT02991.1 - 4.1e-07 30.6 0.0 7.2e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ACT02991.1 - 2.9e-06 26.8 0.1 0.01 15.2 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 ACT02991.1 - 5.2e-05 22.6 0.0 0.022 14.0 0.0 2.2 1 1 1 2 2 2 2 NB-ARC domain ATPase_2 PF01637.18 ACT02991.1 - 0.00018 21.5 0.3 0.026 14.4 0.0 2.6 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_2 PF07724.14 ACT02991.1 - 0.00026 21.2 0.0 0.00042 20.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Sigma54_activ_2 PF14532.6 ACT02991.1 - 0.00028 21.0 0.0 0.00051 20.2 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain DUF815 PF05673.13 ACT02991.1 - 0.0003 20.0 0.0 0.00046 19.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 ACT02991.1 - 0.00033 20.9 0.5 0.0077 16.5 0.5 2.8 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 ACT02991.1 - 0.00047 19.5 0.1 0.0014 17.9 0.0 1.8 1 1 1 2 2 2 1 TIP49 P-loop domain RNA_helicase PF00910.22 ACT02991.1 - 0.00072 19.9 0.0 0.0016 18.8 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Rad17 PF03215.15 ACT02991.1 - 0.001 19.0 0.0 0.0037 17.2 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain ABC_tran PF00005.27 ACT02991.1 - 0.0028 18.2 0.1 0.013 16.1 0.0 1.8 1 1 1 2 2 1 1 ABC transporter AAA_3 PF07726.11 ACT02991.1 - 0.0036 17.2 0.0 0.013 15.3 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ACT02991.1 - 0.0042 16.4 0.0 0.0077 15.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_19 PF13245.6 ACT02991.1 - 0.005 17.2 0.1 0.68 10.3 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 ACT02991.1 - 0.0061 16.3 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 ACT02991.1 - 0.0092 15.8 0.0 0.056 13.3 0.0 2.1 1 1 1 2 2 2 1 Chloramphenicol phosphotransferase-like protein MCM PF00493.23 ACT02991.1 - 0.01 15.0 0.0 0.02 14.0 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_33 PF13671.6 ACT02991.1 - 0.011 15.9 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ACT02991.1 - 0.012 15.9 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain DNA_pol3_delta2 PF13177.6 ACT02991.1 - 0.017 14.9 0.0 6.9 6.4 0.0 2.4 1 1 1 2 2 2 0 DNA polymerase III, delta subunit Viral_helicase1 PF01443.18 ACT02991.1 - 0.02 14.6 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PduV-EutP PF10662.9 ACT02991.1 - 0.029 14.1 0.1 0.34 10.6 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.17 ACT02991.1 - 0.031 14.0 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 ACT02991.1 - 0.031 13.9 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.6 ACT02991.1 - 0.034 13.7 0.2 0.11 12.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ACT02991.1 - 0.041 13.6 0.0 0.15 11.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ACT02991.1 - 0.048 13.6 0.0 0.14 12.1 0.0 1.8 2 0 0 2 2 1 0 NACHT domain AAA_17 PF13207.6 ACT02991.1 - 0.052 14.0 0.0 0.21 12.0 0.0 2.2 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 ACT02991.1 - 0.055 12.5 0.2 0.13 11.3 0.0 1.7 2 0 0 2 2 1 0 Type II/IV secretion system protein ResIII PF04851.15 ACT02991.1 - 0.069 13.2 0.1 1.3 9.0 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit ATPase PF06745.13 ACT02991.1 - 0.099 12.0 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 ACT02991.1 - 0.14 11.6 0.0 0.32 10.5 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 ACT02991.1 - 0.15 12.1 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Acetyltransf_1 PF00583.25 ACT02992.1 - 0.0088 16.3 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family MCPsignal PF00015.21 ACT02993.1 - 7.2e-34 117.1 33.6 1.3e-33 116.2 17.3 2.8 2 1 1 3 3 3 3 Methyl-accepting chemotaxis protein (MCP) signalling domain NPV_P10 PF05531.12 ACT02993.1 - 0.00036 20.9 1.3 0.00036 20.9 1.3 3.8 4 1 1 5 5 3 1 Nucleopolyhedrovirus P10 protein DUF4118 PF13493.6 ACT02993.1 - 0.00049 19.9 7.3 0.00049 19.9 7.3 2.1 1 1 0 2 2 2 1 Domain of unknown function (DUF4118) BLOC1_2 PF10046.9 ACT02993.1 - 0.0015 18.8 20.1 0.41 11.0 0.9 4.4 3 2 1 4 4 4 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-F_leu_zip PF10473.9 ACT02993.1 - 0.0096 15.9 3.3 0.0096 15.9 3.3 2.9 2 2 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SHE3 PF17078.5 ACT02993.1 - 0.013 15.2 6.6 0.015 15.0 0.6 2.5 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 DUF948 PF06103.11 ACT02993.1 - 0.052 13.8 26.2 1.2 9.4 3.1 5.6 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Pet20 PF08692.10 ACT02993.1 - 0.18 12.5 0.7 1.3 9.7 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial protein Pet20 DUF3450 PF11932.8 ACT02993.1 - 0.27 10.5 21.3 0.45 9.8 4.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF4077 PF13295.6 ACT02993.1 - 0.4 10.6 10.7 0.73 9.7 10.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4077) Laminin_II PF06009.12 ACT02993.1 - 0.51 10.4 21.8 1 9.3 1.7 4.1 2 2 2 4 4 4 0 Laminin Domain II Sigma70_ner PF04546.13 ACT02993.1 - 1.1 9.1 6.6 1.2 9.0 2.4 2.5 2 1 0 2 2 2 0 Sigma-70, non-essential region PIN_8 PF18476.1 ACT02993.1 - 1.4 8.7 7.8 3.9 7.3 2.5 2.4 2 0 0 2 2 2 0 PIN like domain APG17 PF04108.12 ACT02993.1 - 1.5 7.9 18.2 1.4 8.0 1.6 3.1 2 1 1 3 3 3 0 Autophagy protein Apg17 LOH1CR12 PF10158.9 ACT02993.1 - 1.6 8.8 11.2 1.2 9.2 1.0 3.4 2 1 1 3 3 3 0 Tumour suppressor protein Sec34 PF04136.15 ACT02993.1 - 2.8 7.8 15.6 7 6.5 0.7 4.0 2 2 2 5 5 5 0 Sec34-like family Fib_alpha PF08702.10 ACT02993.1 - 3.3 7.9 18.5 1.5 9.0 1.7 3.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family WXG100 PF06013.12 ACT02993.1 - 3.4 8.0 13.0 13 6.0 2.2 4.0 2 2 1 3 3 3 0 Proteins of 100 residues with WXG Phasin_2 PF09361.10 ACT02993.1 - 4.5 7.6 18.0 0.48 10.7 1.8 4.3 1 1 2 4 4 4 0 Phasin protein MutS_III PF05192.18 ACT02993.1 - 6.5 6.9 10.5 67 3.6 10.5 2.2 1 1 0 1 1 1 0 MutS domain III zf-C4H2 PF10146.9 ACT02993.1 - 7 6.9 9.7 1.3 9.3 1.3 2.5 1 1 0 2 2 2 0 Zinc finger-containing protein EAL PF00563.20 ACT02994.1 - 2.3e-75 253.2 0.0 4.5e-75 252.2 0.0 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 ACT02994.1 - 4.7e-53 179.2 0.1 1e-52 178.2 0.1 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 ACT02994.1 - 2.2e-41 140.3 0.9 2.9e-11 43.5 0.1 4.6 4 0 0 4 4 4 4 PAS domain PAS PF00989.25 ACT02994.1 - 9.2e-34 115.8 0.1 8.4e-10 38.7 0.0 4.5 4 0 0 4 4 4 4 PAS fold PAS_3 PF08447.12 ACT02994.1 - 1.6e-32 111.7 0.1 5.5e-07 29.8 0.0 4.7 4 0 0 4 4 4 4 PAS fold PAS_4 PF08448.10 ACT02994.1 - 3.6e-32 110.9 0.0 5.4e-09 36.3 0.0 4.8 5 0 0 5 5 5 4 PAS fold PAS_8 PF13188.7 ACT02994.1 - 4.2e-27 93.7 1.0 7.2e-08 32.3 0.1 4.9 4 0 0 4 4 4 4 PAS domain PilZ PF07238.14 ACT02994.1 - 4.5e-08 33.4 0.0 1.3e-07 31.9 0.0 1.9 1 0 0 1 1 1 1 PilZ domain PAS_11 PF14598.6 ACT02994.1 - 2.3e-07 30.9 0.1 2.2 8.4 0.0 4.7 4 0 0 4 4 4 2 PAS domain PAS_12 PF18095.1 ACT02994.1 - 0.00025 20.7 2.1 3.2 7.4 0.0 4.3 4 0 0 4 4 4 1 UPF0242 C-terminal PAS-like domain PAS_7 PF12860.7 ACT02994.1 - 0.0026 17.9 1.4 14 5.9 0.0 4.9 4 2 0 4 4 4 1 PAS fold ThiF PF00899.21 ACT02995.1 - 2.9e-36 125.1 0.0 3.6e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 ACT02995.1 - 0.00038 20.7 1.6 0.0014 18.9 1.6 1.9 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 ACT02995.1 - 0.0021 17.7 1.1 0.0052 16.4 0.4 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 ACT02995.1 - 0.0026 17.1 1.9 0.025 14.0 1.4 2.4 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ACT02995.1 - 0.025 15.0 0.1 0.052 14.0 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 ACT02995.1 - 0.038 13.9 0.1 0.072 13.0 0.0 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 ACT02995.1 - 0.042 13.5 0.4 0.078 12.6 0.1 1.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 ACT02995.1 - 0.059 13.6 0.3 0.12 12.6 0.3 1.6 1 0 0 1 1 1 0 TrkA-N domain Cons_hypoth95 PF03602.15 ACT02995.1 - 0.074 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 FAD_binding_3 PF01494.19 ACT02995.1 - 0.11 11.7 0.6 0.18 11.0 0.6 1.3 1 0 0 1 1 1 0 FAD binding domain tRNA-synt_2 PF00152.20 ACT02996.1 - 9e-109 363.3 0.0 1.1e-108 363.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) GAD PF02938.14 ACT02996.1 - 5.2e-24 84.3 0.0 1.1e-23 83.3 0.0 1.6 1 0 0 1 1 1 1 GAD domain tRNA_anti-codon PF01336.25 ACT02996.1 - 1.1e-17 63.7 0.9 3e-16 59.2 0.8 2.5 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ACT02996.1 - 0.00015 21.4 0.1 0.0091 15.5 0.1 2.5 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 ACT02996.1 - 0.004 17.1 0.0 0.0056 16.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_His PF13393.6 ACT02997.1 - 1.4e-45 155.9 0.2 2.9e-45 154.9 0.0 1.6 2 0 0 2 2 2 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 ACT02997.1 - 5.6e-15 55.3 0.4 1.5e-14 53.9 0.4 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ACT02997.1 - 3.4e-14 53.2 0.0 2.4e-13 50.4 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 ACT02997.1 - 0.00036 20.1 0.0 0.46 9.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.20 ACT02997.1 - 0.02 14.0 0.8 1.5 7.8 0.0 2.8 3 0 0 3 3 3 0 tRNA synthetases class II (D, K and N) Glyco_hydro_30 PF02055.16 ACT02997.1 - 0.19 10.6 0.0 0.31 10.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 30 TIM-barrel domain Tyr_Deacylase PF02580.16 ACT02999.1 - 4.1e-58 196.0 0.0 4.6e-58 195.8 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase HD_4 PF13328.6 ACT03000.1 - 1.6e-50 170.9 0.7 3e-50 170.0 0.7 1.5 1 0 0 1 1 1 1 HD domain RelA_SpoT PF04607.17 ACT03000.1 - 5.3e-40 136.4 1.0 2.5e-39 134.2 0.1 2.7 2 0 0 2 2 2 1 Region found in RelA / SpoT proteins TGS PF02824.21 ACT03000.1 - 5.4e-23 80.8 0.0 1.2e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 TGS domain ACT_4 PF13291.6 ACT03000.1 - 5.4e-22 78.2 3.8 1.5e-21 76.7 3.8 1.8 1 0 0 1 1 1 1 ACT domain HD PF01966.22 ACT03000.1 - 5.3e-10 39.6 1.5 3.1e-09 37.1 0.5 2.6 2 0 0 2 2 2 1 HD domain ACT PF01842.25 ACT03000.1 - 8.8e-09 35.0 0.5 2.3e-08 33.6 0.5 1.8 1 0 0 1 1 1 1 ACT domain ThiS PF02597.20 ACT03000.1 - 0.0018 18.9 0.0 0.0079 16.8 0.0 2.1 1 0 0 1 1 1 1 ThiS family ACT_6 PF13740.6 ACT03000.1 - 0.0052 16.7 0.1 0.015 15.3 0.1 1.7 1 0 0 1 1 1 1 ACT domain Latarcin PF10279.9 ACT03000.1 - 0.011 16.1 0.0 17 5.9 1.5 3.8 2 1 0 2 2 2 0 Latarcin precursor Ub-Mut7C PF14451.6 ACT03000.1 - 0.051 13.4 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 Mut7-C ubiquitin SIS PF01380.22 ACT03000.1 - 0.11 12.4 0.0 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 SIS domain His_kinase PF06580.13 ACT03001.1 - 2.6e-24 85.3 0.8 2.6e-24 85.3 0.8 2.2 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT03001.1 - 1e-10 41.8 2.4 1e-10 41.8 2.4 1.6 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACT03001.1 - 8.8e-09 35.9 0.1 2.3e-08 34.5 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT03001.1 - 9.5e-07 29.1 0.0 2e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c_2 PF13581.6 ACT03001.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Response_reg PF00072.24 ACT03002.1 - 1.3e-22 80.0 0.0 2.1e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT03002.1 - 3e-19 69.1 0.0 5.4e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03002.1 - 1.3e-16 60.2 0.0 2e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Hpr_kinase_C PF07475.12 ACT03002.1 - 0.11 12.0 0.1 2.1 7.8 0.0 2.5 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain SBP_bac_1 PF01547.25 ACT03003.1 - 1.9e-16 60.9 16.5 1.9e-16 60.9 16.5 2.3 2 1 1 3 3 3 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT03003.1 - 9.9e-06 25.5 0.4 0.23 11.2 0.0 3.2 3 0 0 3 3 3 2 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT03004.1 - 2.1e-15 57.0 22.7 8.7e-15 54.9 22.7 2.0 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF3176 PF11374.8 ACT03004.1 - 0.16 12.2 0.3 0.16 12.2 0.3 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3176) BPD_transp_1 PF00528.22 ACT03005.1 - 2.3e-17 63.3 14.4 2.3e-17 63.3 14.4 2.1 2 0 0 2 2 2 2 Binding-protein-dependent transport system inner membrane component DUF3377 PF11857.8 ACT03005.1 - 0.032 14.1 1.7 0.48 10.4 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Pribosyltran PF00156.27 ACT03006.1 - 1.3e-17 63.8 0.1 1.5e-17 63.6 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ACT03006.1 - 0.057 12.8 0.0 0.075 12.5 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase RecJ_OB PF17768.1 ACT03007.1 - 3.5e-27 94.8 0.0 6.3e-27 93.9 0.0 1.5 1 0 0 1 1 1 1 RecJ OB domain ssDNA-exonuc_C PF10141.9 ACT03007.1 - 2.5e-20 73.0 0.0 4.8e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Single-strand DNA-specific exonuclease, C terminal domain DHHA1 PF02272.19 ACT03007.1 - 4.9e-16 59.4 0.0 9.5e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.20 ACT03007.1 - 5.3e-10 39.4 0.0 1.1e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 DHH family ADH_zinc_N PF00107.26 ACT03007.1 - 0.049 13.6 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Usp PF00582.26 ACT03007.1 - 0.078 13.5 0.3 8.2 6.9 0.0 2.6 2 0 0 2 2 2 0 Universal stress protein family ZT_dimer PF16916.5 ACT03008.1 - 1.4e-17 63.6 2.4 2.1e-17 63.0 2.4 1.2 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Cation_efflux PF01545.21 ACT03008.1 - 5.8e-15 55.6 10.3 1.5e-12 47.7 10.3 2.2 1 1 0 1 1 1 1 Cation efflux family SecD_SecF PF02355.16 ACT03009.1 - 1e-54 184.8 11.7 1e-54 184.8 11.7 1.7 2 0 0 2 2 2 1 Protein export membrane protein Sec_GG PF07549.14 ACT03009.1 - 0.0041 16.6 0.1 0.0093 15.4 0.1 1.6 1 0 0 1 1 1 1 SecD/SecF GG Motif DUF3197 PF11432.8 ACT03009.1 - 0.032 14.1 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3197) Imm17 PF15562.6 ACT03009.1 - 0.29 11.0 0.0 0.29 11.0 0.0 3.0 3 0 0 3 3 3 0 Immunity protein 17 SecD_SecF PF02355.16 ACT03010.1 - 3e-14 52.8 13.4 5.3e-14 52.0 13.4 1.3 1 0 0 1 1 1 1 Protein export membrane protein ACR_tran PF00873.19 ACT03010.1 - 4.1e-06 24.8 10.6 5.8e-06 24.3 10.6 1.1 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 ACT03010.1 - 5.1e-06 25.6 9.4 9.7e-06 24.7 9.4 1.4 1 0 0 1 1 1 1 MMPL family Post_transc_reg PF13797.6 ACT03011.1 - 4.4e-20 71.3 0.0 5.4e-20 71.1 0.0 1.1 1 0 0 1 1 1 1 Post-transcriptional regulator YqzH PF14164.6 ACT03011.1 - 0.13 12.3 0.2 1.2 9.2 0.0 2.1 1 1 1 2 2 2 0 YqzH-like protein Polysacc_synt PF01943.17 ACT03012.1 - 1.2e-40 139.7 13.1 1.2e-40 139.7 13.1 2.9 1 1 2 3 3 3 2 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.6 ACT03012.1 - 1.7e-21 76.8 23.4 1.7e-21 76.8 23.4 4.3 4 2 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain MatE PF01554.18 ACT03012.1 - 6.6e-15 55.1 35.5 3.5e-08 33.3 8.0 3.8 3 1 0 3 3 3 2 MatE MurJ PF03023.14 ACT03012.1 - 9.6e-12 44.2 29.7 1.8e-11 43.3 29.6 1.6 1 1 0 1 1 1 1 Lipid II flippase MurJ DUF421 PF04239.12 ACT03013.1 - 4.4e-34 116.5 0.2 2.5e-33 114.1 0.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF421) CBP4 PF07960.11 ACT03013.1 - 0.005 16.7 0.1 0.0081 16.0 0.1 1.3 1 0 0 1 1 1 1 CBP4 GramPos_pilinD1 PF16555.5 ACT03013.1 - 0.021 15.0 0.1 0.027 14.6 0.1 1.1 1 0 0 1 1 1 0 Gram-positive pilin subunit D1, N-terminal domain DUF805 PF05656.14 ACT03013.1 - 0.066 13.6 4.2 0.098 13.1 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF805) CitMHS PF03600.16 ACT03014.1 - 1.2e-52 179.0 34.1 1.2e-52 179.0 34.1 2.0 1 1 1 2 2 2 1 Citrate transporter ArsB PF02040.15 ACT03014.1 - 5.6e-21 75.4 33.3 6.9e-21 75.1 33.3 1.0 1 0 0 1 1 1 1 Arsenical pump membrane protein Na_sulph_symp PF00939.19 ACT03014.1 - 1.3e-18 67.3 38.3 8.2e-11 41.6 12.5 2.1 1 1 1 2 2 2 2 Sodium:sulfate symporter transmembrane region DUF4131 PF13567.6 ACT03014.1 - 0.024 14.3 8.9 3.8 7.1 0.0 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) YiaAB PF05360.14 ACT03014.1 - 3.5 7.9 16.9 1.8 8.9 2.0 4.7 3 2 0 3 3 3 0 yiaA/B two helix domain DUF3792 PF12670.7 ACT03015.1 - 1.3e-24 86.5 18.1 1.6e-24 86.2 18.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3792) DUF2273 PF10031.9 ACT03015.1 - 0.044 13.8 3.7 0.044 13.8 3.7 3.1 4 0 0 4 4 4 0 Small integral membrane protein (DUF2273) DUF2198 PF09964.9 ACT03015.1 - 0.29 11.2 0.1 0.29 11.2 0.1 2.4 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2198) EMP70 PF02990.16 ACT03015.1 - 0.31 9.7 3.0 0.34 9.5 3.0 1.2 1 0 0 1 1 1 0 Endomembrane protein 70 7TM-7TMR_HD PF07698.11 ACT03015.1 - 0.5 10.1 11.7 1.8 8.3 11.8 1.7 1 1 0 1 1 1 0 7TM receptor with intracellular HD hydrolase Gram_pos_anchor PF00746.21 ACT03015.1 - 6.1 6.9 0.0 6.1 6.9 0.0 3.7 3 1 1 4 4 4 0 LPXTG cell wall anchor motif DUF2953 PF11167.8 ACT03015.1 - 8.2 6.6 10.5 2.2 8.4 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2953) YajC PF02699.15 ACT03016.1 - 1.1e-29 102.1 0.3 1.4e-29 101.8 0.3 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Orf78 PF06024.12 ACT03016.1 - 0.018 15.4 0.1 0.03 14.6 0.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) MLANA PF14991.6 ACT03016.1 - 0.087 13.1 0.1 0.23 11.8 0.1 1.8 1 1 0 1 1 1 0 Protein melan-A TGT PF01702.18 ACT03017.1 - 5e-159 529.1 0.0 5.7e-159 528.9 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Queuosine_synth PF02547.15 ACT03018.1 - 2e-139 464.2 0.0 2.3e-139 464.1 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein PQQ_2 PF13360.6 ACT03018.1 - 0.095 12.3 0.0 0.19 11.3 0.0 1.5 2 0 0 2 2 2 0 PQQ-like domain SpoIID PF08486.10 ACT03019.1 - 7.9e-26 90.5 0.2 2.5e-25 88.9 0.2 1.9 1 0 0 1 1 1 1 Stage II sporulation protein SH3_3 PF08239.11 ACT03019.1 - 2e-05 24.8 3.2 0.28 11.5 0.1 4.1 4 0 0 4 4 4 2 Bacterial SH3 domain SPOR PF05036.13 ACT03019.1 - 0.039 14.3 9.1 0.24 11.8 0.3 3.5 4 0 0 4 4 4 0 Sporulation related domain DUF393 PF04134.12 ACT03020.1 - 7.2e-26 91.7 0.0 8.4e-26 91.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF393 RuvB_N PF05496.12 ACT03021.1 - 4.7e-84 279.9 0.0 6.8e-84 279.4 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_4 PF17864.1 ACT03021.1 - 2.6e-31 107.2 0.7 5.1e-31 106.2 0.7 1.5 1 0 0 1 1 1 1 RuvB AAA lid domain RuvB_C PF05491.13 ACT03021.1 - 2.3e-26 91.4 0.0 4.3e-26 90.6 0.0 1.5 1 0 0 1 1 1 1 RuvB C-terminal winged helix domain AAA PF00004.29 ACT03021.1 - 3e-20 73.0 0.0 6.4e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ACT03021.1 - 2.2e-11 43.9 0.1 7.8e-10 38.9 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ACT03021.1 - 1.1e-05 24.9 0.3 0.024 14.0 0.0 2.7 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ACT03021.1 - 1.3e-05 24.6 0.1 0.00014 21.1 0.0 2.0 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_16 PF13191.6 ACT03021.1 - 0.00042 20.7 0.1 0.018 15.4 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ACT03021.1 - 0.00086 19.6 0.3 0.19 12.0 0.0 2.6 1 1 1 2 2 2 1 AAA domain Sigma54_activat PF00158.26 ACT03021.1 - 0.0009 19.0 0.0 1.5 8.5 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_14 PF13173.6 ACT03021.1 - 0.0012 18.9 0.0 0.0037 17.3 0.0 1.8 1 1 1 2 2 2 1 AAA domain TsaE PF02367.17 ACT03021.1 - 0.0012 18.8 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 ACT03021.1 - 0.0023 17.9 0.2 0.12 12.3 0.0 2.5 2 1 1 3 3 2 1 NTPase Rad17 PF03215.15 ACT03021.1 - 0.0027 17.7 0.0 0.0042 17.0 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_18 PF13238.6 ACT03021.1 - 0.0027 18.3 0.0 0.0074 16.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_3 PF07726.11 ACT03021.1 - 0.0028 17.5 0.0 0.043 13.7 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 ACT03021.1 - 0.0035 17.4 0.0 0.006 16.7 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Resolvase PF00239.21 ACT03021.1 - 0.0036 17.4 0.0 0.013 15.6 0.0 1.9 2 0 0 2 2 2 1 Resolvase, N terminal domain RNA_helicase PF00910.22 ACT03021.1 - 0.0063 16.9 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Bac_DnaA PF00308.18 ACT03021.1 - 0.0065 16.3 0.2 0.2 11.5 0.0 2.4 3 0 0 3 3 3 1 Bacterial dnaA protein DUF815 PF05673.13 ACT03021.1 - 0.013 14.7 0.0 0.5 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 ACT03021.1 - 0.017 14.3 0.0 0.063 12.5 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain MCM PF00493.23 ACT03021.1 - 0.021 13.9 0.1 5.8 5.9 0.0 2.6 2 1 1 3 3 3 0 MCM P-loop domain AAA_24 PF13479.6 ACT03021.1 - 0.022 14.5 0.1 0.065 13.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 ACT03021.1 - 0.032 14.3 0.0 3.6 7.6 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_2 PF07724.14 ACT03021.1 - 0.055 13.6 0.0 1.2 9.3 0.0 2.3 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 ACT03021.1 - 0.082 13.1 0.0 0.22 11.7 0.0 1.7 2 0 0 2 2 1 0 AAA domain TniB PF05621.11 ACT03021.1 - 0.11 11.8 0.2 2.9 7.3 0.0 2.2 1 1 1 2 2 2 0 Bacterial TniB protein AAA_19 PF13245.6 ACT03021.1 - 0.12 12.7 0.3 2 8.8 0.0 2.5 1 1 1 2 2 2 0 AAA domain HTH_15 PF12324.8 ACT03021.1 - 0.12 12.3 0.1 3.5 7.7 0.0 2.7 3 0 0 3 3 2 0 Helix-turn-helix domain of alkylmercury lyase AAA_17 PF13207.6 ACT03021.1 - 0.13 12.7 0.0 0.33 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACT03021.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 ACT03021.1 - 0.18 12.3 0.0 0.35 11.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_13 PF13166.6 ACT03021.1 - 0.23 10.1 0.0 0.3 9.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain RuvA_N PF01330.21 ACT03022.1 - 7e-20 70.9 0.4 2.9e-19 68.9 0.2 2.0 2 0 0 2 2 2 1 RuvA N terminal domain HHH_5 PF14520.6 ACT03022.1 - 1e-17 64.4 0.4 2.2e-17 63.4 0.4 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain RuvA_C PF07499.13 ACT03022.1 - 1.3e-08 35.1 1.4 2.9e-08 34.0 1.4 1.5 1 0 0 1 1 1 1 RuvA, C-terminal domain Transposase_20 PF02371.16 ACT03022.1 - 3.8e-07 30.3 0.6 1.1e-05 25.6 0.1 2.2 2 0 0 2 2 2 1 Transposase IS116/IS110/IS902 family HHH PF00633.23 ACT03022.1 - 0.00018 21.2 0.5 0.03 14.2 0.0 2.7 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_3 PF12836.7 ACT03022.1 - 0.0011 19.1 0.0 0.071 13.4 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_8 PF14716.6 ACT03022.1 - 0.0062 16.9 0.5 0.63 10.4 0.0 2.6 3 0 0 3 3 3 1 Helix-hairpin-helix domain HHH_2 PF12826.7 ACT03022.1 - 0.009 16.1 0.1 4.5 7.5 0.0 2.8 3 0 0 3 3 3 1 Helix-hairpin-helix motif IMS_HHH PF11798.8 ACT03022.1 - 0.038 14.3 0.2 0.13 12.7 0.0 2.0 2 0 0 2 2 2 0 IMS family HHH motif Cdd1 PF11731.8 ACT03022.1 - 0.15 12.3 0.0 0.71 10.2 0.0 2.1 2 0 0 2 2 2 0 Pathogenicity locus RuvC PF02075.17 ACT03023.1 - 2.7e-57 192.8 0.4 3.1e-57 192.6 0.4 1.0 1 0 0 1 1 1 1 Crossover junction endodeoxyribonuclease RuvC KduI PF04962.12 ACT03023.1 - 0.099 11.9 0.2 0.25 10.6 0.1 1.5 1 1 1 2 2 2 0 KduI/IolB family BofC_C PF08955.10 ACT03024.1 - 2.1e-29 101.3 0.3 3.4e-29 100.7 0.3 1.3 1 0 0 1 1 1 1 BofC C-terminal domain DGOK PF05035.12 ACT03024.1 - 0.11 11.4 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 2-keto-3-deoxy-galactonokinase LysM PF01476.20 ACT03025.1 - 1.1e-25 89.4 0.3 5.2e-14 52.0 0.0 2.4 2 0 0 2 2 2 2 LysM domain PDT PF00800.18 ACT03026.1 - 5e-44 150.3 0.0 6.3e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 ACT03026.1 - 1.3e-07 31.2 0.0 2.5e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 ACT domain GHMP_kinases_N PF00288.26 ACT03027.1 - 2.6e-13 50.0 1.0 7.2e-13 48.6 1.0 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ACT03027.1 - 2.9e-11 43.6 0.5 7e-11 42.3 0.1 1.8 2 0 0 2 2 2 1 GHMP kinases C terminal Homoserine_dh PF00742.19 ACT03028.1 - 2.3e-67 226.3 0.2 3.3e-66 222.5 0.2 2.2 2 0 0 2 2 2 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 ACT03028.1 - 7.2e-19 68.6 0.1 1.6e-18 67.5 0.1 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ACT PF01842.25 ACT03028.1 - 1.6e-11 43.7 0.1 3.4e-11 42.7 0.1 1.6 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 ACT03028.1 - 0.0013 19.2 0.2 0.0052 17.3 0.2 2.0 1 0 0 1 1 1 1 ACT domain GFO_IDH_MocA PF01408.22 ACT03028.1 - 0.0048 17.7 1.7 0.26 12.1 0.1 2.7 3 0 0 3 3 3 1 Oxidoreductase family, NAD-binding Rossmann fold Sacchrp_dh_NADP PF03435.18 ACT03028.1 - 0.059 13.6 0.4 0.23 11.7 0.1 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DUF1611_N PF17396.2 ACT03028.1 - 0.085 13.1 0.0 0.32 11.2 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1611_N) Rossmann-like domain ACT_6 PF13740.6 ACT03028.1 - 0.11 12.5 0.1 0.41 10.7 0.0 2.0 2 0 0 2 2 2 0 ACT domain DAHP_snth_FXD PF18152.1 ACT03028.1 - 0.28 11.0 2.7 1.6 8.6 0.4 2.9 2 0 0 2 2 2 0 DAHP synthase ferredoxin-like domain ACT PF01842.25 ACT03029.1 - 3.4e-06 26.7 0.4 6.5e-06 25.8 0.4 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 ACT03029.1 - 3.3e-05 24.4 1.2 4.9e-05 23.8 1.2 1.2 1 0 0 1 1 1 1 ACT domain HTH_7 PF02796.15 ACT03029.1 - 0.039 14.0 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_29 PF13551.6 ACT03029.1 - 0.065 13.3 0.0 0.13 12.3 0.0 1.7 1 1 0 1 1 1 0 Winged helix-turn helix GTP1_OBG PF01018.22 ACT03030.1 - 2.5e-59 199.3 5.3 4.7e-59 198.4 5.3 1.5 1 0 0 1 1 1 1 GTP1/OBG DUF1967 PF09269.11 ACT03030.1 - 4.6e-24 84.1 1.4 7.9e-24 83.4 0.7 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1967) MMR_HSR1 PF01926.23 ACT03030.1 - 3.2e-23 82.0 0.0 5.8e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ACT03030.1 - 1.1e-09 38.0 0.1 5.4e-09 35.8 0.1 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 ACT03030.1 - 3.4e-07 29.9 0.0 7.5e-07 28.8 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family MeaB PF03308.16 ACT03030.1 - 0.022 13.8 3.0 0.96 8.4 0.2 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Gtr1_RagA PF04670.12 ACT03030.1 - 0.024 14.0 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region MMR_HSR1_C PF08438.10 ACT03030.1 - 0.052 14.1 0.1 0.4 11.3 0.1 2.4 1 1 0 1 1 1 0 GTPase of unknown function C-terminal GTP_EFTU PF00009.27 ACT03030.1 - 0.068 12.7 0.1 0.21 11.1 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 ACT03030.1 - 0.19 12.2 0.3 0.47 11.0 0.0 1.7 2 1 0 2 2 2 0 ABC transporter SPOB_a PF14689.6 ACT03031.1 - 1e-19 70.0 0.9 2.5e-19 68.7 0.9 1.7 1 0 0 1 1 1 1 Sensor_kinase_SpoOB-type, alpha-helical domain Ribosomal_L27 PF01016.19 ACT03032.1 - 2.8e-37 126.6 2.9 3.3e-37 126.4 2.9 1.0 1 0 0 1 1 1 1 Ribosomal L27 protein Peptidase_Prp PF04327.12 ACT03033.1 - 7.7e-26 90.2 0.0 8.7e-26 90.0 0.0 1.0 1 0 0 1 1 1 1 Cysteine protease Prp Ribosomal_L21p PF00829.21 ACT03034.1 - 2e-42 143.6 5.4 2.2e-42 143.4 5.4 1.0 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Cupin_2 PF07883.11 ACT03034.1 - 0.1 12.3 0.6 0.47 10.2 0.0 2.3 2 1 1 3 3 3 0 Cupin domain YchF-GTPase_C PF06071.13 ACT03034.1 - 0.11 12.7 1.4 0.14 12.3 0.1 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF933) RNase_E_G PF10150.9 ACT03035.1 - 3.9e-92 308.5 0.0 4.9e-92 308.2 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease E/G family S1 PF00575.23 ACT03035.1 - 1e-05 25.7 0.0 2.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 S1 RNA binding domain Peptidase_M50 PF02163.22 ACT03036.1 - 2.6e-14 53.1 7.9 1.9e-07 30.6 1.5 2.7 1 1 1 2 2 2 2 Peptidase family M50 Peptidase_M50B PF13398.6 ACT03036.1 - 0.24 11.0 12.9 0.22 11.1 7.3 2.3 1 1 1 2 2 2 0 Peptidase M50B-like DUF5326 PF17260.2 ACT03036.1 - 0.38 10.9 6.8 1.3 9.2 4.4 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5326) Peptidase_M23 PF01551.22 ACT03037.1 - 4.2e-18 65.3 0.1 8.1e-18 64.4 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M23 Biotin_lipoyl_2 PF13533.6 ACT03037.1 - 0.02 14.7 0.0 0.054 13.3 0.0 1.7 1 0 0 1 1 1 0 Biotin-lipoyl like FTO_CTD PF12934.7 ACT03037.1 - 0.036 13.8 2.0 0.06 13.1 2.0 1.3 1 0 0 1 1 1 0 FTO C-terminal domain FTSW_RODA_SPOVE PF01098.19 ACT03038.1 - 2.7e-80 270.1 25.6 3.4e-80 269.7 25.6 1.0 1 0 0 1 1 1 1 Cell cycle protein DUF4229 PF14012.6 ACT03038.1 - 0.0073 16.4 0.4 0.0073 16.4 0.4 3.4 3 1 0 3 3 3 1 Protein of unknown function (DUF4229) CbiA PF01656.23 ACT03039.1 - 6.9e-27 94.0 0.2 8.9e-27 93.7 0.2 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ACT03039.1 - 6.2e-25 88.1 0.1 1.3e-24 87.1 0.1 1.5 1 1 0 1 1 1 1 AAA domain ParA PF10609.9 ACT03039.1 - 5.2e-23 81.8 5.2 1e-21 77.5 5.2 2.1 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase MipZ PF09140.11 ACT03039.1 - 4.3e-13 49.1 0.6 6.9e-13 48.5 0.6 1.4 1 1 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 ACT03039.1 - 1.3e-12 47.8 2.9 1.6e-05 24.5 0.1 2.1 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 ACT03039.1 - 1.9e-11 43.9 0.4 1.7e-10 40.8 0.4 2.0 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ArsA_ATPase PF02374.15 ACT03039.1 - 1e-08 34.8 8.1 1.8e-07 30.7 1.5 2.8 2 1 1 3 3 3 2 Anion-transporting ATPase AAA_24 PF13479.6 ACT03039.1 - 9.8e-05 22.2 0.0 0.00018 21.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_26 PF13500.6 ACT03039.1 - 0.0022 17.9 8.6 0.014 15.2 1.4 2.8 2 1 0 2 2 2 1 AAA domain CLP1_P PF16575.5 ACT03039.1 - 0.0027 17.5 0.4 0.0072 16.1 0.1 1.8 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop SRP54 PF00448.22 ACT03039.1 - 0.0047 16.6 3.9 0.018 14.6 1.9 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain VirC1 PF07015.11 ACT03039.1 - 0.0084 15.4 1.7 0.044 13.1 0.5 2.4 2 1 1 3 3 3 1 VirC1 protein RsgA_GTPase PF03193.16 ACT03039.1 - 0.019 14.9 2.6 0.31 11.0 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 ACT03039.1 - 0.034 14.3 0.2 0.073 13.2 0.2 1.7 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ACT03039.1 - 0.12 12.2 1.3 0.63 9.8 1.3 1.9 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 ACT03039.1 - 0.22 11.2 1.8 3.3 7.4 0.8 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ACT03039.1 - 0.32 10.5 3.5 1.3 8.6 3.5 1.9 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 ACT03039.1 - 0.98 8.3 3.8 0.57 9.1 1.5 2.0 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MinC_C PF03775.16 ACT03040.1 - 1.6e-29 101.9 0.0 3.2e-29 100.9 0.0 1.5 1 0 0 1 1 1 1 Septum formation inhibitor MinC, C-terminal domain FapA PF03961.13 ACT03040.1 - 0.0094 14.6 0.4 0.029 13.0 0.2 1.7 2 0 0 2 2 2 1 Flagellar Assembly Protein A MreD PF04093.12 ACT03041.1 - 1.2e-14 54.7 16.4 1.4e-14 54.5 16.4 1.0 1 0 0 1 1 1 1 rod shape-determining protein MreD MreC PF04085.14 ACT03042.1 - 3.9e-36 124.2 1.7 7.4e-36 123.3 1.7 1.4 1 1 1 2 2 2 1 rod shape-determining protein MreC HALZ PF02183.18 ACT03042.1 - 0.46 10.7 3.4 0.67 10.2 0.1 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper MreB_Mbl PF06723.13 ACT03043.1 - 3e-154 512.7 6.0 3.4e-154 512.5 6.0 1.0 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.6 ACT03043.1 - 4.5e-12 46.3 2.3 2.1e-11 44.1 0.1 2.5 2 1 0 2 2 2 1 Cell division protein FtsA Actin PF00022.19 ACT03043.1 - 1.1e-11 44.0 0.1 1.1e-06 27.5 0.0 2.1 2 0 0 2 2 2 2 Actin HSP70 PF00012.20 ACT03043.1 - 5.6e-10 38.0 3.2 4.9e-09 34.9 0.3 2.5 1 1 1 2 2 2 2 Hsp70 protein PilM_2 PF11104.8 ACT03043.1 - 3.6e-06 26.3 0.0 0.021 13.8 0.0 2.4 2 1 0 2 2 2 2 Type IV pilus assembly protein PilM; EutA PF06277.11 ACT03043.1 - 0.0027 16.6 1.0 0.013 14.4 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation protein EutA DDR PF08841.10 ACT03043.1 - 0.0059 15.6 1.7 0.015 14.3 1.7 1.8 1 1 0 1 1 1 1 Diol dehydratase reactivase ATPase-like domain RadC PF04002.15 ACT03044.1 - 5.8e-48 161.9 0.0 8.9e-48 161.3 0.0 1.3 1 0 0 1 1 1 1 RadC-like JAB domain HHH_2 PF12826.7 ACT03044.1 - 0.00024 21.1 0.0 0.00046 20.2 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif Prok-JAB PF14464.6 ACT03044.1 - 0.00068 19.4 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain HHH PF00633.23 ACT03044.1 - 0.0038 17.0 0.0 0.009 15.8 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 ACT03044.1 - 0.006 17.2 0.0 0.012 16.2 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain Molybdopterin_N PF18364.1 ACT03044.1 - 0.028 14.4 0.1 0.19 11.8 0.0 2.3 3 0 0 3 3 3 0 Molybdopterin oxidoreductase N-terminal domain Maf PF02545.14 ACT03045.1 - 5.2e-56 189.1 0.0 5.8e-56 188.9 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein DUF4321 PF14209.6 ACT03046.1 - 4.2e-12 45.7 2.0 4.2e-12 45.7 2.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4321) Spore_YabQ PF09578.10 ACT03046.1 - 0.02 15.1 1.1 3.6 7.9 0.0 2.2 2 0 0 2 2 2 0 Spore cortex protein YabQ (Spore_YabQ) FtsX PF02687.21 ACT03046.1 - 0.023 15.1 3.2 0.027 15.0 3.2 1.1 1 0 0 1 1 1 0 FtsX-like permease family ATPase_gene1 PF09527.10 ACT03046.1 - 0.023 14.8 3.3 0.18 12.0 1.0 2.2 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter CPP1-like PF11833.8 ACT03046.1 - 0.3 10.7 1.8 0.24 11.0 0.8 1.4 1 1 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF2897 PF11446.8 ACT03046.1 - 2.2 8.2 5.6 0.65 9.9 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2897) SPOR PF05036.13 ACT03047.1 - 0.0071 16.7 0.3 0.015 15.6 0.3 1.5 1 0 0 1 1 1 1 Sporulation related domain HTH_42 PF06224.12 ACT03047.1 - 0.042 13.4 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain Mur_ligase_M PF08245.12 ACT03048.1 - 4.6e-29 101.8 0.2 9.6e-29 100.7 0.2 1.5 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase PF01225.25 ACT03048.1 - 5.5e-27 93.9 0.9 2.4e-26 91.9 0.6 2.3 2 0 0 2 2 2 1 Mur ligase family, catalytic domain Mur_ligase_C PF02875.21 ACT03048.1 - 9.7e-22 77.0 0.1 2.2e-20 72.7 0.0 2.9 3 0 0 3 3 3 1 Mur ligase family, glutamate ligase domain Mur_ligase_M PF08245.12 ACT03049.1 - 3.3e-16 59.9 0.2 5.1e-16 59.2 0.2 1.3 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 ACT03049.1 - 2.7e-09 37.2 0.0 7.5e-09 35.7 0.0 1.8 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain tRNA-synt_1 PF00133.22 ACT03050.1 - 3e-223 742.4 1.0 1.3e-221 737.0 1.0 2.7 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ACT03050.1 - 1.7e-43 148.2 0.5 2.8e-43 147.5 0.5 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ACT03050.1 - 2.7e-28 98.8 0.1 2.9e-14 52.6 0.2 3.7 2 2 0 2 2 2 2 tRNA synthetases class I (M) Val_tRNA-synt_C PF10458.9 ACT03050.1 - 2.4e-23 82.2 5.2 5.5e-23 81.0 5.2 1.7 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1_2 PF13603.6 ACT03050.1 - 4.4e-11 42.6 0.0 1.7e-07 30.9 0.0 2.5 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 ACT03050.1 - 1.6e-05 24.4 0.0 0.0022 17.4 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 ACT03050.1 - 0.0021 17.0 0.0 0.013 14.4 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (K) zf-ribbon_3 PF13248.6 ACT03050.1 - 0.0072 15.7 0.8 0.014 14.8 0.8 1.4 1 0 0 1 1 1 1 zinc-ribbon domain ABC_tran_CTD PF16326.5 ACT03050.1 - 0.032 14.5 1.4 0.082 13.2 1.4 1.7 1 0 0 1 1 1 0 ABC transporter C-terminal domain CCDC-167 PF15188.6 ACT03050.1 - 0.059 13.7 1.6 0.16 12.3 1.6 1.8 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 tRNA-synt_1b PF00579.25 ACT03050.1 - 0.14 11.5 0.4 0.57 9.5 0.0 2.1 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) Zn-ribbon_8 PF09723.10 ACT03050.1 - 0.29 11.3 0.9 0.61 10.2 0.9 1.5 1 0 0 1 1 1 0 Zinc ribbon domain MFS_1 PF07690.16 ACT03051.1 - 5.4e-58 196.6 45.7 2.7e-56 191.0 44.1 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT03051.1 - 2.3e-14 53.1 25.7 4.5e-10 39.0 12.6 2.8 2 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 ACT03051.1 - 4.3e-07 28.7 15.8 4.3e-07 28.7 15.8 2.7 1 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) LacY_symp PF01306.19 ACT03051.1 - 8.4e-06 24.8 10.4 0.0031 16.3 0.5 3.0 3 0 0 3 3 3 2 LacY proton/sugar symporter MFS_1_like PF12832.7 ACT03051.1 - 8.2e-05 21.6 17.7 0.01 14.8 1.2 2.2 2 0 0 2 2 2 2 MFS_1 like family MFS_2 PF13347.6 ACT03051.1 - 0.00015 20.5 8.0 0.00015 20.5 8.0 3.5 2 2 1 3 3 3 3 MFS/sugar transport protein TetR_N PF00440.23 ACT03052.1 - 2e-13 49.9 0.0 5.4e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_Tnp_1_2 PF13022.6 ACT03052.1 - 0.0021 18.2 0.0 0.0038 17.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase HTH_7 PF02796.15 ACT03052.1 - 0.011 15.8 0.5 2.2 8.4 0.1 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 ACT03052.1 - 0.047 13.5 0.1 13 5.8 0.0 3.3 3 1 1 4 4 4 0 Homeodomain-like domain EcoEI_R_C PF08463.10 ACT03052.1 - 0.087 12.9 0.1 0.24 11.5 0.1 1.8 1 1 1 2 2 2 0 EcoEI R protein C-terminal DUF1706 PF08020.11 ACT03052.1 - 0.094 12.6 0.1 0.52 10.2 0.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1706) DUF3907 PF13047.6 ACT03052.1 - 0.098 12.6 0.4 5.6 6.9 0.1 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3907) LysM PF01476.20 ACT03053.1 - 2.4e-07 30.7 0.0 4.2e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 LysM domain PseudoU_synth_2 PF00849.22 ACT03054.1 - 5e-32 111.2 0.0 6.7e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 RNA pseudouridylate synthase Aminotran_3 PF00202.21 ACT03055.1 - 7.4e-74 248.8 0.0 8.9e-74 248.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ACT03055.1 - 0.0032 16.7 0.0 0.02 14.1 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class I and II ALAD PF00490.21 ACT03056.1 - 9.6e-152 504.7 0.2 1.1e-151 504.5 0.2 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase HEM4 PF02602.15 ACT03057.1 - 1.1e-64 218.0 0.1 1.5e-64 217.5 0.1 1.2 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD TP_methylase PF00590.20 ACT03057.1 - 1e-48 166.1 0.2 2e-48 165.2 0.2 1.5 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DAHP_snth_FXD PF18152.1 ACT03057.1 - 0.01 15.6 0.1 0.043 13.7 0.1 2.1 1 0 0 1 1 1 0 DAHP synthase ferredoxin-like domain NTP_transf_3 PF12804.7 ACT03057.1 - 0.056 13.8 0.1 2 8.8 0.1 2.8 1 1 0 2 2 2 0 MobA-like NTP transferase domain Porphobil_deam PF01379.20 ACT03058.1 - 1e-81 273.3 0.0 1.3e-81 273.0 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 ACT03058.1 - 3.7e-19 68.9 0.0 6.6e-19 68.1 0.0 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain NAD_binding_7 PF13241.6 ACT03059.1 - 8.6e-23 80.8 0.0 1.9e-22 79.6 0.0 1.5 2 0 0 2 2 2 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 ACT03059.1 - 6.4e-09 35.1 0.1 1.5e-08 33.9 0.1 1.7 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central F420_oxidored PF03807.17 ACT03059.1 - 0.087 13.4 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Cytochrom_C_asm PF01578.20 ACT03060.1 - 9.8e-13 48.4 17.1 7.4e-12 45.5 17.1 2.3 1 1 0 1 1 1 1 Cytochrome C assembly protein GlutR_N PF05201.15 ACT03061.1 - 1.2e-49 167.8 0.5 2.7e-49 166.7 0.5 1.6 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.20 ACT03061.1 - 1.3e-47 161.3 0.1 3.6e-47 159.9 0.0 1.8 2 0 0 2 2 1 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.20 ACT03061.1 - 1.1e-23 83.4 2.4 1.1e-23 83.4 2.4 2.8 4 0 0 4 4 3 1 Glutamyl-tRNAGlu reductase, dimerisation domain F420_oxidored PF03807.17 ACT03061.1 - 3.5e-07 30.7 0.8 8.8e-07 29.4 0.2 2.1 2 0 0 2 2 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 ACT03061.1 - 7.5e-06 26.3 1.4 3.8e-05 24.1 0.1 2.6 3 0 0 3 3 2 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 ACT03061.1 - 0.0002 21.6 0.1 0.00052 20.3 0.1 1.8 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 ACT03061.1 - 0.00025 21.3 0.3 0.00082 19.6 0.1 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 ACT03061.1 - 0.0003 20.2 0.1 0.001 18.5 0.1 1.9 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 ACT03061.1 - 0.00034 20.6 0.1 0.00082 19.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 ACT03061.1 - 0.00035 20.8 0.8 0.001 19.3 0.2 2.2 2 1 0 2 2 1 1 TrkA-N domain Glu_dehyd_C PF16912.5 ACT03061.1 - 0.00078 19.0 0.3 0.0019 17.7 0.2 1.7 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus ETF PF01012.21 ACT03061.1 - 0.01 15.7 0.3 0.01 15.7 0.3 1.8 2 0 0 2 2 1 0 Electron transfer flavoprotein domain IlvN PF07991.12 ACT03061.1 - 0.011 15.3 0.2 0.021 14.4 0.2 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ApbA PF02558.16 ACT03061.1 - 0.028 14.0 0.0 0.066 12.9 0.0 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA adh_short PF00106.25 ACT03061.1 - 0.031 13.7 0.3 0.078 12.4 0.3 1.8 1 1 0 1 1 1 0 short chain dehydrogenase FAD_binding_3 PF01494.19 ACT03061.1 - 0.033 13.5 0.0 0.078 12.2 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 ACT03061.1 - 0.035 13.4 0.1 0.072 12.3 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase KR PF08659.10 ACT03061.1 - 0.052 13.5 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 KR domain AdoHcyase_NAD PF00670.21 ACT03061.1 - 0.054 13.6 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain GFO_IDH_MocA PF01408.22 ACT03061.1 - 0.063 14.1 1.1 0.48 11.3 0.1 2.8 3 0 0 3 3 3 0 Oxidoreductase family, NAD-binding Rossmann fold DUF4924 PF16271.5 ACT03061.1 - 0.082 12.9 3.3 0.16 12.0 3.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) AdoMet_dc PF02675.15 ACT03062.1 - 3.9e-37 126.7 0.1 4.5e-37 126.5 0.1 1.0 1 0 0 1 1 1 1 S-adenosylmethionine decarboxylase SusD-like_3 PF14322.6 ACT03064.1 - 0.095 13.0 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Starch-binding associating with outer membrane MMR_HSR1 PF01926.23 ACT03065.1 - 1.3e-20 73.6 0.0 1.7e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ACT03065.1 - 5.7e-07 29.2 0.0 6.7e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ACT03065.1 - 3e-06 27.3 0.0 0.00081 19.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 ACT03065.1 - 2.8e-05 24.3 0.1 0.15 12.1 0.1 2.2 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.10 ACT03065.1 - 6.3e-05 22.5 0.0 0.00028 20.4 0.0 1.9 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AIG1 PF04548.16 ACT03065.1 - 0.0011 18.3 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 ACT03065.1 - 0.0013 18.3 0.0 0.094 12.2 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 ACT03065.1 - 0.0045 17.2 0.2 0.044 14.0 0.2 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 ACT03065.1 - 0.026 14.9 0.1 0.069 13.6 0.0 1.7 2 0 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 ACT03065.1 - 0.056 13.7 0.0 0.14 12.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 ACT03065.1 - 0.089 12.2 0.0 0.36 10.2 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein Lon_C PF05362.13 ACT03066.1 - 2.1e-97 324.6 0.3 4.7e-97 323.5 0.3 1.6 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 ACT03066.1 - 1.9e-39 135.7 0.9 1.9e-39 135.7 0.9 1.7 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 ACT03066.1 - 6.7e-24 84.8 0.0 2e-23 83.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 ACT03066.1 - 7.5e-10 38.7 0.2 2.9e-09 36.8 0.1 2.0 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 ACT03066.1 - 3.6e-09 36.7 0.1 2.4e-08 34.1 0.0 2.5 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ACT03066.1 - 4.9e-06 27.0 2.7 3.3e-05 24.3 0.0 3.4 4 1 0 4 4 3 1 AAA ATPase domain AAA_18 PF13238.6 ACT03066.1 - 6.4e-06 26.7 1.3 0.0083 16.7 0.0 3.9 3 1 1 4 4 4 1 AAA domain AAA_PrkA PF08298.11 ACT03066.1 - 1.8e-05 23.8 0.0 3.5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_22 PF13401.6 ACT03066.1 - 5.7e-05 23.4 0.2 0.0013 19.0 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ACT03066.1 - 5.8e-05 23.3 0.0 0.00024 21.3 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_3 PF07726.11 ACT03066.1 - 0.00019 21.3 0.0 0.00064 19.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ACT03066.1 - 0.00036 20.5 0.0 0.0012 18.8 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase AAA_14 PF13173.6 ACT03066.1 - 0.00044 20.3 0.0 0.0046 17.0 0.0 2.5 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 ACT03066.1 - 0.00084 18.6 2.8 0.0099 15.1 0.0 3.1 3 1 0 3 3 3 1 NB-ARC domain IstB_IS21 PF01695.17 ACT03066.1 - 0.0016 18.2 1.0 0.0035 17.1 0.0 2.1 3 0 0 3 3 2 1 IstB-like ATP binding protein RuvB_N PF05496.12 ACT03066.1 - 0.0019 18.0 0.0 0.0066 16.2 0.0 1.9 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 ACT03066.1 - 0.0025 17.7 0.0 0.048 13.6 0.0 2.8 3 0 0 3 3 2 1 NACHT domain DUF815 PF05673.13 ACT03066.1 - 0.0041 16.3 0.0 0.1 11.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) TsaE PF02367.17 ACT03066.1 - 0.0064 16.5 0.0 0.033 14.2 0.0 2.2 2 0 0 2 2 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ACT03066.1 - 0.0067 16.6 0.0 0.0067 16.6 0.0 2.5 4 0 0 4 4 2 1 AAA domain NTPase_1 PF03266.15 ACT03066.1 - 0.011 15.7 3.6 0.12 12.3 0.0 3.3 4 0 0 4 4 2 0 NTPase RNA_helicase PF00910.22 ACT03066.1 - 0.011 16.1 0.0 0.035 14.5 0.0 1.9 1 0 0 1 1 1 0 RNA helicase MMR_HSR1 PF01926.23 ACT03066.1 - 0.012 15.7 0.3 0.6 10.2 0.0 3.0 3 0 0 3 3 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 ACT03066.1 - 0.013 16.1 6.5 6.1 7.3 7.2 2.6 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ACT03066.1 - 0.015 15.8 1.0 0.11 13.0 0.0 2.6 2 0 0 2 2 2 0 ABC transporter TIP49 PF06068.13 ACT03066.1 - 0.018 14.3 0.0 0.018 14.3 0.0 2.5 3 0 0 3 3 3 0 TIP49 P-loop domain AAA_7 PF12775.7 ACT03066.1 - 0.03 13.8 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 ACT03066.1 - 0.03 14.6 1.4 0.42 10.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain IPT PF01745.16 ACT03066.1 - 0.03 13.7 0.3 10 5.4 0.0 3.2 3 0 0 3 3 3 0 Isopentenyl transferase Zeta_toxin PF06414.12 ACT03066.1 - 0.031 13.5 0.0 0.099 11.9 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin Rad17 PF03215.15 ACT03066.1 - 0.059 13.3 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_24 PF13479.6 ACT03066.1 - 0.076 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ACT03066.1 - 0.11 12.0 0.2 5.9 6.4 0.0 3.5 4 0 0 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.21 ACT03066.1 - 0.15 11.5 0.9 1 8.7 0.1 2.7 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI AAA_17 PF13207.6 ACT03066.1 - 0.16 12.4 5.0 0.23 11.9 0.0 3.5 3 0 0 3 3 3 0 AAA domain CorA PF01544.18 ACT03066.1 - 2.1 7.6 5.4 0.97 8.7 3.0 1.7 2 0 0 2 2 1 0 CorA-like Mg2+ transporter protein MeaB PF03308.16 ACT03066.1 - 2.2 7.2 7.3 0.9 8.5 0.2 2.7 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MPS2 PF17060.5 ACT03066.1 - 2.6 7.2 7.8 1.3 8.3 3.7 2.0 2 0 0 2 2 2 0 Monopolar spindle protein 2 AAA_11 PF13086.6 ACT03066.1 - 8.3 6.1 7.0 5.6 6.7 0.0 2.7 2 1 0 2 2 2 0 AAA domain Lon_C PF05362.13 ACT03067.1 - 2.7e-31 108.7 0.4 6.5e-31 107.5 0.4 1.5 1 1 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 ACT03067.1 - 8.7e-19 68.3 0.0 1.7e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ACT03067.1 - 9.8e-15 54.5 0.0 1.8e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ACT03067.1 - 7.2e-12 45.3 0.0 6.1e-11 42.3 0.0 2.3 2 1 0 2 2 2 1 Sigma-54 interaction domain RuvB_N PF05496.12 ACT03067.1 - 2.4e-10 40.4 0.5 3.2e-06 27.0 0.0 3.7 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain ChlI PF13541.6 ACT03067.1 - 1.4e-09 37.8 0.0 3.2e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 ACT03067.1 - 1.7e-08 34.5 0.0 8e-08 32.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ACT03067.1 - 1.5e-06 28.7 0.0 2.4e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_32 PF13654.6 ACT03067.1 - 3e-06 26.3 0.0 0.011 14.5 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 ACT03067.1 - 0.00011 22.5 0.0 0.00029 21.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 ACT03067.1 - 0.00019 21.6 0.0 0.0007 19.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) DNA_pol3_delta2 PF13177.6 ACT03067.1 - 0.00019 21.3 0.0 0.23 11.3 0.0 3.1 3 0 0 3 3 3 1 DNA polymerase III, delta subunit AAA_30 PF13604.6 ACT03067.1 - 0.00059 19.6 0.0 0.0021 17.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ACT03067.1 - 0.002 18.1 0.0 0.0072 16.3 0.0 2.0 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 ACT03067.1 - 0.0028 18.0 0.0 0.33 11.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain MCM PF00493.23 ACT03067.1 - 0.0071 15.5 0.0 0.07 12.2 0.0 2.0 2 0 0 2 2 2 1 MCM P-loop domain Sigma54_activ_2 PF14532.6 ACT03067.1 - 0.013 15.6 0.0 2.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 ACT03067.1 - 0.028 14.3 0.0 0.86 9.5 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_7 PF12775.7 ACT03067.1 - 0.079 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 ACT03067.1 - 0.094 13.3 0.0 0.19 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ACT03067.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 ACT03067.1 - 0.11 12.2 0.0 0.3 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain GcpE PF04551.14 ACT03068.1 - 1.8e-140 468.0 2.2 2.1e-140 467.8 2.2 1.0 1 0 0 1 1 1 1 GcpE protein zf-RING_7 PF02591.15 ACT03068.1 - 0.1 12.8 0.1 1.6 9.0 0.0 2.5 2 0 0 2 2 2 0 C4-type zinc ribbon domain AAA_2 PF07724.14 ACT03069.1 - 9.4e-50 169.1 0.0 1.6e-49 168.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) zf-C4_ClpX PF06689.13 ACT03069.1 - 3.2e-20 71.7 4.6 7.2e-20 70.6 4.6 1.6 1 0 0 1 1 1 1 ClpX C4-type zinc finger ClpB_D2-small PF10431.9 ACT03069.1 - 2.9e-17 62.5 0.4 9.8e-17 60.8 0.5 2.0 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 ACT03069.1 - 3.2e-16 60.0 0.1 9.3e-16 58.5 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ACT03069.1 - 9.1e-07 29.0 0.0 1.2e-05 25.3 0.2 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ACT03069.1 - 6.5e-06 25.7 0.0 0.00047 19.6 0.0 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 ACT03069.1 - 1.3e-05 25.0 0.1 3.7e-05 23.5 0.1 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 ACT03069.1 - 1.7e-05 24.6 0.0 0.0045 16.7 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 ACT03069.1 - 1.7e-05 25.1 0.1 0.00015 22.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain MCM PF00493.23 ACT03069.1 - 2.6e-05 23.5 0.1 4.7e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain Sigma54_activ_2 PF14532.6 ACT03069.1 - 0.00061 19.9 0.0 0.0017 18.5 0.0 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain T2SSE PF00437.20 ACT03069.1 - 0.00063 18.9 0.0 0.001 18.2 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 ACT03069.1 - 0.00084 18.9 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 ACT03069.1 - 0.0026 18.2 0.1 0.014 15.8 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 ACT03069.1 - 0.0038 17.3 0.0 0.0081 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 ACT03069.1 - 0.0042 17.1 0.0 0.0094 15.9 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 ACT03069.1 - 0.005 16.6 0.0 0.0094 15.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 ACT03069.1 - 0.0065 15.7 0.1 0.012 14.8 0.1 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_8 PF12780.7 ACT03069.1 - 0.012 14.9 0.0 0.036 13.4 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 AAA_24 PF13479.6 ACT03069.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ACT03069.1 - 0.019 14.4 0.0 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein DEAD PF00270.29 ACT03069.1 - 0.019 14.7 0.1 0.049 13.4 0.1 1.9 1 1 0 1 1 1 0 DEAD/DEAH box helicase ResIII PF04851.15 ACT03069.1 - 0.023 14.7 0.0 0.091 12.8 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 ACT03069.1 - 0.031 14.8 0.0 0.084 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ACT03069.1 - 0.031 14.0 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ACT03069.1 - 0.032 14.8 0.0 0.08 13.5 0.0 1.8 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 ACT03069.1 - 0.041 13.8 0.0 0.19 11.6 0.0 2.0 2 0 0 2 2 2 0 NACHT domain ATPase PF06745.13 ACT03069.1 - 0.059 12.7 0.8 0.71 9.2 0.8 2.2 1 1 0 1 1 1 0 KaiC FtsK_SpoIIIE PF01580.18 ACT03069.1 - 0.069 12.5 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family B12-binding_2 PF02607.17 ACT03069.1 - 0.074 13.5 0.0 0.29 11.6 0.0 2.0 1 0 0 1 1 1 0 B12 binding domain AAA_33 PF13671.6 ACT03069.1 - 0.082 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ACT03069.1 - 0.095 13.1 0.0 0.24 11.8 0.0 1.8 1 1 0 1 1 1 0 RNA helicase PduV-EutP PF10662.9 ACT03069.1 - 0.11 12.3 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRP54 PF00448.22 ACT03069.1 - 0.11 12.1 0.1 0.59 9.7 0.1 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 ACT03069.1 - 0.18 11.3 0.6 0.79 9.3 0.6 1.9 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ACT03069.1 - 0.19 12.1 0.7 0.75 10.1 0.1 2.3 2 1 1 3 3 2 0 AAA domain C1_2 PF03107.16 ACT03069.1 - 0.19 12.1 1.8 0.38 11.1 1.8 1.5 1 0 0 1 1 1 0 C1 domain CLP_protease PF00574.23 ACT03070.1 - 1e-89 299.3 0.0 1.2e-89 299.1 0.0 1.0 1 0 0 1 1 1 1 Clp protease Trigger_C PF05698.14 ACT03071.1 - 7.2e-43 146.4 15.9 7.2e-43 146.4 15.9 2.5 3 0 0 3 3 3 1 Bacterial trigger factor protein (TF) C-terminus Trigger_N PF05697.13 ACT03071.1 - 2.4e-42 144.6 15.3 6e-42 143.3 5.4 3.3 2 1 0 2 2 2 1 Bacterial trigger factor protein (TF) FKBP_C PF00254.28 ACT03071.1 - 1.7e-15 57.1 1.7 5.2e-15 55.5 0.2 2.6 3 0 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase SurA_N PF09312.11 ACT03071.1 - 0.011 15.8 2.9 0.043 13.9 2.0 2.5 1 1 1 2 2 2 0 SurA N-terminal domain PG_binding_4 PF12229.8 ACT03071.1 - 0.014 15.6 3.6 2.3 8.5 0.4 3.5 3 0 0 3 3 3 0 Putative peptidoglycan binding domain SurA_N_3 PF13624.6 ACT03071.1 - 0.018 14.9 3.3 0.018 14.9 3.3 2.5 2 1 1 3 3 3 0 SurA N-terminal domain HisKA_2 PF07568.12 ACT03071.1 - 0.043 13.9 0.5 5.3 7.2 0.0 2.9 2 0 0 2 2 2 0 Histidine kinase SurA_N_2 PF13623.6 ACT03071.1 - 0.85 9.5 10.7 0.15 12.0 4.6 2.6 2 1 1 3 3 3 0 SurA N-terminal domain HxlR PF01638.17 ACT03073.1 - 4.4e-37 125.8 0.1 5.9e-37 125.4 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.14 ACT03073.1 - 0.056 13.4 0.1 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family HTH_34 PF13601.6 ACT03073.1 - 0.13 12.4 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain Nitroreductase PF00881.24 ACT03074.1 - 6.3e-26 91.4 0.0 8.2e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 ACT03074.1 - 9e-05 22.1 0.0 0.074 12.6 0.0 2.2 2 0 0 2 2 2 2 Putative TM nitroreductase AAA_33 PF13671.6 ACT03075.1 - 2.1e-13 50.6 0.1 2.8e-13 50.3 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ACT03075.1 - 1.9e-06 28.4 0.1 2.8e-06 27.9 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ACT03075.1 - 0.00029 21.3 0.0 0.0004 20.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT03075.1 - 0.00058 20.3 0.0 0.00064 20.1 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 ACT03075.1 - 0.0044 16.8 0.3 0.015 15.0 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ACT03075.1 - 0.0077 16.7 0.0 0.019 15.4 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SKI PF01202.22 ACT03075.1 - 0.0092 16.1 0.1 0.018 15.1 0.0 1.7 2 0 0 2 2 1 1 Shikimate kinase AAA_22 PF13401.6 ACT03075.1 - 0.0093 16.2 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 ACT03075.1 - 0.0093 15.9 0.0 0.013 15.4 0.0 1.5 1 1 0 1 1 1 1 Adenylylsulphate kinase AAA_5 PF07728.14 ACT03075.1 - 0.012 15.6 0.0 0.026 14.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 ACT03075.1 - 0.016 14.4 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain SRP54 PF00448.22 ACT03075.1 - 0.017 14.8 0.0 0.04 13.5 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NACHT PF05729.12 ACT03075.1 - 0.021 14.7 0.0 0.053 13.4 0.0 1.8 2 0 0 2 2 2 0 NACHT domain Cytidylate_kin PF02224.18 ACT03075.1 - 0.029 14.1 0.0 0.041 13.6 0.0 1.3 1 1 0 1 1 1 0 Cytidylate kinase AAA_28 PF13521.6 ACT03075.1 - 0.034 14.4 0.0 0.051 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain CPT PF07931.12 ACT03075.1 - 0.036 13.9 0.0 0.045 13.6 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein DUF2075 PF09848.9 ACT03075.1 - 0.04 13.1 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PRK PF00485.18 ACT03075.1 - 0.043 13.5 0.1 2.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ABC_tran PF00005.27 ACT03075.1 - 0.046 14.2 0.2 0.13 12.8 0.2 1.9 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 ACT03075.1 - 0.055 13.2 0.3 0.08 12.6 0.3 1.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ACT03075.1 - 0.067 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Thymidylate_kin PF02223.17 ACT03075.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase Asn_synthase PF00733.21 ACT03077.1 - 5e-93 312.6 0.0 6.5e-93 312.2 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 ACT03077.1 - 5.9e-47 158.6 0.0 1.1e-46 157.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ACT03077.1 - 9.3e-41 139.2 0.0 1.7e-40 138.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 ACT03077.1 - 0.004 16.6 0.0 0.0087 15.5 0.0 1.6 1 1 0 1 1 1 1 Aluminium induced protein Ham1p_like PF01725.16 ACT03078.1 - 1.2e-60 204.7 0.0 1.4e-60 204.5 0.0 1.0 1 0 0 1 1 1 1 Ham1 family RNase_PH PF01138.21 ACT03079.1 - 3.1e-24 86.0 0.1 8.3e-24 84.6 0.1 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ACT03079.1 - 3.8e-12 46.0 0.1 8.4e-12 45.0 0.1 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Ost5 PF05251.12 ACT03079.1 - 0.12 12.6 0.6 0.2 12.0 0.6 1.3 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 Germane PF10646.9 ACT03080.1 - 4.3e-32 111.0 4.7 1e-16 61.6 2.6 2.1 2 0 0 2 2 2 2 Sporulation and spore germination DUF2505 PF10698.9 ACT03080.1 - 0.18 11.9 3.2 3.3 7.8 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2505) YfhO PF09586.10 ACT03080.1 - 0.3 9.3 1.4 0.41 8.8 1.4 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO PgpA PF04608.13 ACT03081.1 - 7e-19 68.3 0.0 8.4e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylglycerophosphatase A Swi3 PF07962.12 ACT03081.1 - 0.01 15.8 0.0 0.022 14.7 0.0 1.6 1 1 0 1 1 1 0 Replication Fork Protection Component Swi3 DUF826 PF05696.11 ACT03081.1 - 0.028 14.5 1.4 0.2 11.8 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF826) APS_kinase PF01583.20 ACT03082.1 - 3.1e-70 235.1 0.0 3.9e-70 234.8 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 ACT03082.1 - 1.8e-07 31.4 0.0 2.4e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ACT03082.1 - 1.4e-06 28.9 0.0 2.4e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT03082.1 - 0.00012 22.5 0.0 0.00012 22.5 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain KTI12 PF08433.10 ACT03082.1 - 0.00047 19.7 0.0 0.00053 19.5 0.0 1.3 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.6 ACT03082.1 - 0.0021 18.5 0.0 0.004 17.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain CPT PF07931.12 ACT03082.1 - 0.0024 17.7 0.4 0.079 12.8 0.4 2.2 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 ACT03082.1 - 0.0025 17.1 0.0 0.0037 16.6 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin HMGL-like PF00682.19 ACT03082.1 - 0.0035 17.0 0.0 0.0046 16.6 0.0 1.1 1 0 0 1 1 1 1 HMGL-like ABC_tran PF00005.27 ACT03082.1 - 0.0047 17.4 0.0 0.0069 16.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 ACT03082.1 - 0.0071 16.1 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SRP54 PF00448.22 ACT03082.1 - 0.0081 15.8 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_22 PF13401.6 ACT03082.1 - 0.0096 16.2 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 ACT03082.1 - 0.012 15.6 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 ACT03082.1 - 0.014 14.9 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase Rad17 PF03215.15 ACT03082.1 - 0.031 14.2 0.0 0.045 13.7 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain dNK PF01712.19 ACT03082.1 - 0.04 13.8 0.0 3.4 7.5 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase RNA_helicase PF00910.22 ACT03082.1 - 0.043 14.2 0.0 0.077 13.4 0.0 1.4 1 0 0 1 1 1 0 RNA helicase DUF87 PF01935.17 ACT03082.1 - 0.045 13.9 0.0 0.097 12.8 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain PRK PF00485.18 ACT03082.1 - 0.048 13.4 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 ACT03082.1 - 0.057 12.6 0.0 0.13 11.5 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain MeaB PF03308.16 ACT03082.1 - 0.086 11.8 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 ACT03082.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 ACT03082.1 - 0.15 11.8 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 ACT03082.1 - 0.15 11.2 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sulfotransfer_2 PF03567.14 ACT03083.1 - 2.6e-12 47.2 0.9 7.9e-12 45.6 0.9 1.7 1 1 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 ACT03083.1 - 3.1e-07 29.6 1.5 4.8e-07 29.0 1.5 1.3 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Lactamase_B PF00753.27 ACT03084.1 - 1.2e-25 90.7 0.2 1.8e-25 90.1 0.2 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ACT03084.1 - 0.00018 21.1 0.1 0.00039 20.0 0.1 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ACT03084.1 - 0.00075 19.4 0.0 0.0021 18.0 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain SF3a60_bindingd PF12108.8 ACT03084.1 - 0.0099 15.7 0.4 0.021 14.7 0.4 1.5 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain BLACT_WH PF17778.1 ACT03084.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase associated winged helix domain FMN_dh PF01070.18 ACT03085.1 - 1.8e-25 89.7 2.8 2.7e-23 82.6 2.8 2.1 1 1 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 ACT03085.1 - 6.6e-06 25.4 2.7 0.00025 20.1 0.2 2.9 3 1 1 4 4 4 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 ACT03085.1 - 0.00027 20.2 2.6 0.00087 18.5 2.6 1.8 1 1 0 1 1 1 1 Conserved region in glutamate synthase PcrB PF01884.17 ACT03085.1 - 0.061 12.8 0.0 0.83 9.1 0.0 2.1 2 0 0 2 2 2 0 PcrB family HTH_Tnp_Mu_2 PF09039.11 ACT03085.1 - 0.11 12.5 0.1 7.9 6.6 0.0 2.5 2 0 0 2 2 2 0 Mu DNA binding, I gamma subdomain Glucosamine_iso PF01182.20 ACT03086.1 - 3.1e-20 73.0 0.0 4.5e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase HV_small_capsid PF17086.5 ACT03086.1 - 0.15 12.3 0.1 0.88 9.9 0.0 2.1 2 0 0 2 2 2 0 Small capsid protein of Herpesviridae Amidohydro_1 PF01979.20 ACT03087.1 - 2.3e-32 112.7 0.0 3.1e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ACT03087.1 - 1.3e-12 47.9 2.1 1.8e-08 34.3 0.0 3.0 2 1 1 3 3 3 2 Amidohydrolase family DeoRC PF00455.22 ACT03088.1 - 2.2e-46 157.7 0.7 2.8e-46 157.4 0.7 1.1 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 ACT03088.1 - 5.2e-19 67.7 0.2 1.5e-18 66.3 0.2 1.8 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACT03088.1 - 1.8e-09 37.4 0.1 4.7e-09 36.0 0.1 1.7 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 ACT03088.1 - 8.8e-06 25.2 0.2 0.0054 16.3 0.1 2.6 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 ACT03088.1 - 0.00038 20.2 0.1 0.0013 18.5 0.2 1.9 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain MarR PF01047.22 ACT03088.1 - 0.0017 18.2 0.2 0.01 15.7 0.1 2.2 3 0 0 3 3 3 1 MarR family HTH_Mga PF08280.11 ACT03088.1 - 0.0045 17.0 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_39 PF14090.6 ACT03088.1 - 0.0048 16.6 1.7 0.025 14.3 0.4 2.4 3 0 0 3 3 3 1 Helix-turn-helix domain RRF_GI PF12614.8 ACT03088.1 - 0.0073 16.5 0.1 0.018 15.2 0.1 1.6 1 0 0 1 1 1 1 Ribosome recycling factor DUF977 PF06163.11 ACT03088.1 - 0.016 15.1 0.1 0.038 13.9 0.1 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) HTH_23 PF13384.6 ACT03088.1 - 0.036 13.9 2.7 0.042 13.7 0.7 2.2 2 0 0 2 2 2 0 Homeodomain-like domain HTH_IclR PF09339.10 ACT03088.1 - 0.044 13.6 0.1 0.11 12.3 0.1 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_20 PF12840.7 ACT03088.1 - 0.046 13.8 0.3 0.13 12.3 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain FeoC PF09012.10 ACT03088.1 - 0.099 12.7 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 FeoC like transcriptional regulator PfkB PF00294.24 ACT03089.1 - 4.4e-58 197.0 0.0 4.9e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF4134 PF13572.6 ACT03090.1 - 0.052 13.8 5.1 0.076 13.3 5.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4134) DUF2269 PF10027.9 ACT03090.1 - 0.07 13.2 12.1 0.18 11.9 12.1 1.7 1 1 0 1 1 1 0 Predicted integral membrane protein (DUF2269) SPT_ssu-like PF11779.8 ACT03090.1 - 3.3 7.4 10.7 0.33 10.6 0.8 2.4 1 1 1 2 2 2 0 Small subunit of serine palmitoyltransferase-like RQC PF09382.10 ACT03091.1 - 1.1e-28 99.3 0.0 2.3e-28 98.3 0.0 1.6 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 ACT03091.1 - 2.5e-25 89.0 0.0 6.5e-22 78.0 0.0 2.8 3 0 0 3 3 3 2 Helicase conserved C-terminal domain HTH_40 PF14493.6 ACT03091.1 - 3.8e-23 81.7 0.0 1.1e-22 80.2 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HRDC PF00570.23 ACT03091.1 - 1e-19 70.2 0.0 2e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 HRDC domain DEAD PF00270.29 ACT03091.1 - 2.5e-18 66.5 0.0 9.3e-18 64.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 ACT03091.1 - 4e-17 62.7 1.2 7e-17 61.9 0.6 1.8 2 0 0 2 2 2 1 RecQ zinc-binding Ldh_1_N PF00056.23 ACT03092.1 - 4.4e-40 137.0 0.5 6.2e-40 136.5 0.5 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 ACT03092.1 - 7e-26 91.1 0.0 1.3e-25 90.3 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 ACT03092.1 - 1.9e-05 24.3 1.3 0.024 14.2 0.1 2.5 1 1 1 2 2 2 2 Family 4 glycosyl hydrolase DAO PF01266.24 ACT03092.1 - 3.2e-05 23.7 1.1 0.0024 17.5 0.4 2.7 1 1 2 3 3 3 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 ACT03092.1 - 3.7e-05 23.4 1.7 9e-05 22.1 1.7 1.6 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 ACT03092.1 - 0.051 12.8 0.3 0.11 11.7 0.1 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ACT03092.1 - 0.068 13.0 0.3 0.18 11.6 0.3 1.8 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Iso_dh PF00180.20 ACT03093.1 - 1.8e-119 399.0 0.1 2.1e-119 398.8 0.1 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Citrate_synt PF00285.21 ACT03094.1 - 1.3e-128 429.1 0.1 1.5e-128 428.9 0.1 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Ppx-GppA PF02541.16 ACT03095.1 - 7e-59 199.6 0.0 2.5e-58 197.8 0.0 1.8 2 0 0 2 2 2 1 Ppx/GppA phosphatase family FtsA PF14450.6 ACT03095.1 - 2.1e-05 24.9 0.9 0.06 13.8 0.0 3.2 2 1 0 2 2 2 2 Cell division protein FtsA RRM_3 PF08777.11 ACT03095.1 - 0.2 11.7 0.0 0.38 10.8 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif PP_kinase_C_1 PF17941.1 ACT03096.1 - 1.1e-75 252.8 0.2 3e-75 251.4 0.0 1.9 2 0 0 2 2 2 1 Polyphosphate kinase C-terminal domain 1 PP_kinase_C PF13090.6 ACT03096.1 - 2.4e-75 251.8 1.1 4e-74 247.8 0.2 2.3 2 0 0 2 2 2 1 Polyphosphate kinase C-terminal domain 2 PP_kinase PF02503.17 ACT03096.1 - 3.7e-69 232.4 2.5 4.2e-69 232.2 0.9 1.8 2 0 0 2 2 2 1 Polyphosphate kinase middle domain PP_kinase_N PF13089.6 ACT03096.1 - 2e-33 114.9 0.0 5.5e-33 113.5 0.0 1.8 1 0 0 1 1 1 1 Polyphosphate kinase N-terminal domain PLDc_2 PF13091.6 ACT03096.1 - 3.8e-13 49.5 0.2 5.2e-07 29.6 0.0 3.0 2 1 0 2 2 2 2 PLD-like domain MR_MLE_C PF13378.6 ACT03096.1 - 0.054 13.1 0.1 0.092 12.3 0.1 1.3 1 0 0 1 1 1 0 Enolase C-terminal domain-like AbrB_C PF18277.1 ACT03096.1 - 0.12 12.0 0.1 0.3 10.7 0.1 1.7 1 0 0 1 1 1 0 AbrB C-terminal domain Succ_CoA_lig PF13607.6 ACT03096.1 - 0.17 11.7 0.1 0.37 10.6 0.1 1.5 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain 4HBT PF03061.22 ACT03097.1 - 1.7e-13 50.7 0.0 2.7e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 ACT03097.1 - 2.1e-06 28.3 0.0 2.3e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily PK PF00224.21 ACT03098.1 - 2.1e-153 510.3 6.1 3.5e-153 509.6 6.1 1.3 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 ACT03098.1 - 2.8e-36 124.3 1.4 2.8e-36 124.3 1.4 2.2 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain PEP-utilizers PF00391.23 ACT03098.1 - 2.4e-19 68.8 3.6 2.4e-19 68.8 1.0 2.4 2 0 0 2 2 2 1 PEP-utilising enzyme, mobile domain HpcH_HpaI PF03328.14 ACT03098.1 - 1.2e-05 24.6 0.8 3.2e-05 23.2 0.5 1.9 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family ACCA PF03255.14 ACT03099.1 - 1.3e-58 197.0 0.0 2.4e-58 196.1 0.0 1.5 1 0 0 1 1 1 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Carboxyl_trans PF01039.22 ACT03099.1 - 1.1e-15 57.3 0.0 1.3e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 ACT03099.1 - 0.0014 18.2 0.1 0.0019 17.7 0.1 1.3 1 0 0 1 1 1 1 Malonate decarboxylase gamma subunit (MdcE) HTH_35 PF13693.6 ACT03099.1 - 0.081 13.0 0.1 5.3 7.2 0.0 3.1 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding Swi5 PF07061.11 ACT03099.1 - 1 9.5 4.0 0.32 11.1 0.5 2.1 2 0 0 2 2 2 0 Swi5 Carboxyl_trans PF01039.22 ACT03100.1 - 6.3e-17 61.4 0.0 8.3e-17 61.0 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain zf-ACC PF17848.1 ACT03100.1 - 1.8e-06 27.9 5.2 1.8e-06 27.9 5.2 1.6 2 0 0 2 2 2 1 Acetyl-coA carboxylase zinc finger domain DUF35_N PF12172.8 ACT03100.1 - 0.031 14.2 0.3 4.3 7.3 0.0 2.3 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-ribbon_3 PF13248.6 ACT03100.1 - 0.046 13.1 2.3 3 7.4 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.6 ACT03100.1 - 0.063 13.2 0.4 6.9 6.7 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain GATA PF00320.27 ACT03100.1 - 0.082 12.5 1.0 0.26 10.9 1.0 1.8 1 1 0 1 1 1 0 GATA zinc finger OrfB_Zn_ribbon PF07282.11 ACT03100.1 - 0.082 12.8 3.2 0.16 11.9 3.2 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-NADH-PPase PF09297.11 ACT03100.1 - 0.1 12.3 2.1 6.2 6.6 0.6 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain UPF0547 PF10571.9 ACT03100.1 - 0.14 12.3 0.3 12 6.1 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zinc_ribbon_2 PF13240.6 ACT03100.1 - 0.24 11.1 3.5 8.4 6.3 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Nudix_N_2 PF14803.6 ACT03100.1 - 0.34 10.9 3.9 4.8 7.2 0.3 2.5 2 0 0 2 2 2 0 Nudix N-terminal Flavodoxin_5 PF12724.7 ACT03101.1 - 0.09 13.0 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 Flavodoxin domain PgpA PF04608.13 ACT03102.1 - 1.8e-18 67.0 0.0 2.2e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylglycerophosphatase A DNA_pol3_alpha PF07733.12 ACT03103.1 - 2e-104 348.8 0.0 3.3e-104 348.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha NTPase domain DNA_pol3_finger PF17657.1 ACT03103.1 - 9.5e-62 207.2 0.0 1.8e-61 206.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha subunit finger domain PHP PF02811.19 ACT03103.1 - 1.4e-55 188.1 0.1 3.3e-55 186.9 0.1 1.7 1 0 0 1 1 1 1 PHP domain HHH_6 PF14579.6 ACT03103.1 - 1.8e-29 101.8 0.0 6.2e-29 100.1 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif DUF655 PF04919.12 ACT03103.1 - 0.017 15.1 0.1 0.036 14.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF655) tRNA_anti-codon PF01336.25 ACT03103.1 - 0.036 14.1 0.1 0.086 12.8 0.1 1.7 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Spore_YtrH PF14034.6 ACT03104.1 - 5.1e-34 116.5 4.2 5.7e-34 116.3 4.2 1.0 1 0 0 1 1 1 1 Sporulation protein YtrH NADH5_C PF06455.11 ACT03104.1 - 6.1 6.4 8.6 8.5 5.9 4.1 2.0 1 1 1 2 2 2 0 NADH dehydrogenase subunit 5 C-terminus BTP PF05232.12 ACT03105.1 - 0.084 12.9 0.2 0.13 12.3 0.2 1.3 1 0 0 1 1 1 0 Chlorhexidine efflux transporter DUF3194 PF11419.8 ACT03105.1 - 0.18 12.2 0.1 0.18 12.2 0.1 2.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3194) YtpI PF14007.6 ACT03106.1 - 3.1e-26 91.3 5.9 3.6e-26 91.1 5.9 1.0 1 0 0 1 1 1 1 YtpI-like protein DUF4395 PF14340.6 ACT03106.1 - 0.021 15.2 3.5 0.031 14.6 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4395) DUF2243 PF10002.9 ACT03106.1 - 0.027 14.6 1.5 0.046 13.8 1.1 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2243) CYYR1 PF10873.8 ACT03106.1 - 0.26 11.7 1.1 0.76 10.2 1.0 1.7 1 1 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 DUF3040 PF11239.8 ACT03106.1 - 0.28 11.5 6.0 0.23 11.7 4.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) ABC2_membrane_3 PF12698.7 ACT03106.1 - 0.72 8.9 7.6 1 8.4 7.6 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF373 PF04123.13 ACT03106.1 - 0.85 9.0 3.8 0.82 9.1 3.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF373) DUF202 PF02656.15 ACT03106.1 - 1.5 9.3 10.5 9.8 6.7 10.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF4389 PF14333.6 ACT03106.1 - 1.7 8.6 6.2 0.43 10.5 2.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4389) DUF2892 PF11127.8 ACT03106.1 - 5.2 7.2 7.7 1.6 8.8 0.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2892) RsgA_GTPase PF03193.16 ACT03107.1 - 1.6e-46 158.3 0.0 2.8e-46 157.5 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 ACT03107.1 - 5.6e-07 29.6 0.0 1.4e-06 28.3 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ACT03107.1 - 8.3e-06 26.4 0.0 1.6e-05 25.4 0.0 1.6 1 1 0 1 1 1 1 ABC transporter Septin PF00735.18 ACT03107.1 - 0.0033 16.7 0.0 0.0053 16.1 0.0 1.2 1 0 0 1 1 1 1 Septin AAA_29 PF13555.6 ACT03107.1 - 0.005 16.5 0.1 0.015 15.0 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ACT03107.1 - 0.0052 17.1 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ACT03107.1 - 0.006 16.5 0.1 0.012 15.5 0.1 1.5 1 0 0 1 1 1 1 NACHT domain Dynamin_N PF00350.23 ACT03107.1 - 0.0088 16.1 0.0 0.059 13.4 0.0 2.3 1 1 1 2 2 2 1 Dynamin family AAA_16 PF13191.6 ACT03107.1 - 0.015 15.7 0.1 0.026 14.9 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 ACT03107.1 - 0.016 14.8 0.1 0.068 12.7 0.1 1.9 1 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ACT03107.1 - 0.017 15.4 0.1 0.048 13.9 0.1 1.9 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 ACT03107.1 - 0.029 14.9 0.0 0.064 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ACT03107.1 - 0.033 13.9 0.0 6.4 6.5 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 ACT03107.1 - 0.047 13.6 0.0 0.077 12.9 0.0 1.4 1 0 0 1 1 1 0 NTPase KAP_NTPase PF07693.14 ACT03107.1 - 0.047 12.9 0.0 0.11 11.7 0.0 1.8 2 0 0 2 2 2 0 KAP family P-loop domain cobW PF02492.19 ACT03107.1 - 0.061 12.9 0.1 1.7 8.2 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 ACT03107.1 - 0.079 11.9 0.2 0.23 10.4 0.0 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 ACT03107.1 - 0.1 12.1 0.0 0.97 8.9 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_14 PF13173.6 ACT03107.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain DRTGG PF07085.12 ACT03108.1 - 9e-29 99.4 0.0 1.6e-28 98.6 0.0 1.4 1 0 0 1 1 1 1 DRTGG domain CBS PF00571.28 ACT03108.1 - 2.7e-14 53.3 0.3 5.3e-08 33.2 0.1 2.8 2 0 0 2 2 2 2 CBS domain GntR PF00392.21 ACT03108.1 - 1.4e-07 31.0 0.4 6e-07 29.0 0.2 2.2 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_29 PF13551.6 ACT03108.1 - 1.6e-05 24.8 0.2 5.2e-05 23.2 0.2 1.9 1 0 0 1 1 1 1 Winged helix-turn helix HTH_11 PF08279.12 ACT03108.1 - 2.1e-05 24.4 1.1 0.00017 21.4 0.6 2.5 2 0 0 2 2 2 1 HTH domain HTH_23 PF13384.6 ACT03108.1 - 2.4e-05 24.0 0.0 6.2e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 ACT03108.1 - 7.7e-05 22.7 0.6 0.00025 21.1 0.6 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 ACT03108.1 - 0.00011 21.7 0.1 0.00028 20.4 0.1 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding 4HBT PF03061.22 ACT03108.1 - 0.00074 19.8 0.0 0.003 17.9 0.0 2.1 1 0 0 1 1 1 1 Thioesterase superfamily MarR_2 PF12802.7 ACT03108.1 - 0.0011 18.8 0.3 0.0027 17.6 0.3 1.7 1 0 0 1 1 1 1 MarR family Fe_dep_repress PF01325.19 ACT03108.1 - 0.0038 17.4 0.2 0.0073 16.5 0.2 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_38 PF13936.6 ACT03108.1 - 0.0043 16.8 0.1 0.017 14.9 0.2 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_36 PF13730.6 ACT03108.1 - 0.0059 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain PucR PF07905.11 ACT03108.1 - 0.0076 16.5 0.0 0.14 12.4 0.0 2.7 2 1 0 2 2 2 1 Purine catabolism regulatory protein-like family Hpr_kinase_N PF02603.16 ACT03108.1 - 0.011 15.8 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 HPr Serine kinase N terminus TrmB PF01978.19 ACT03108.1 - 0.014 15.3 0.1 0.029 14.3 0.1 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_10 PF04967.12 ACT03108.1 - 0.015 15.1 0.1 0.039 13.7 0.1 1.7 1 0 0 1 1 1 0 HTH DNA binding domain TetR_N PF00440.23 ACT03108.1 - 0.02 14.7 0.2 0.054 13.3 0.2 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_AsnC-type PF13404.6 ACT03108.1 - 0.021 14.7 0.0 0.054 13.3 0.0 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_DeoR PF08220.12 ACT03108.1 - 0.04 13.7 0.1 0.12 12.2 0.1 1.8 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain NUMOD1 PF07453.13 ACT03108.1 - 0.046 14.0 0.0 0.086 13.1 0.0 1.4 1 0 0 1 1 1 0 NUMOD1 domain HTH_Crp_2 PF13545.6 ACT03108.1 - 0.055 13.5 1.2 0.21 11.6 0.4 2.3 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_22 PF13309.6 ACT03108.1 - 0.06 13.4 0.0 0.18 11.9 0.0 1.9 1 0 0 1 1 1 0 HTH domain HTH_41 PF14502.6 ACT03108.1 - 0.064 13.0 0.2 0.14 11.9 0.2 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_17 PF12728.7 ACT03108.1 - 0.079 13.2 0.2 0.32 11.2 0.2 2.1 1 0 0 1 1 1 0 Helix-turn-helix domain LZ_Tnp_IS481 PF13011.6 ACT03108.1 - 0.14 12.7 0.0 0.37 11.4 0.0 1.7 1 0 0 1 1 1 0 leucine-zipper of insertion element IS481 Sigma70_r4_2 PF08281.12 ACT03108.1 - 0.21 11.3 1.2 0.46 10.2 0.1 2.2 3 0 0 3 3 1 0 Sigma-70, region 4 HTH_3 PF01381.22 ACT03110.1 - 1.1e-14 54.2 0.2 2.2e-14 53.2 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix HTH_19 PF12844.7 ACT03110.1 - 1.9e-12 47.0 0.0 2.8e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ACT03110.1 - 5e-11 42.8 0.0 7.1e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 ACT03110.1 - 2.8e-06 27.7 0.0 4.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain YycC PF14174.6 ACT03110.1 - 0.0019 17.9 0.3 0.0038 17.0 0.3 1.5 1 0 0 1 1 1 1 YycC-like protein NOG1 PF06858.14 ACT03110.1 - 0.022 14.5 1.0 2.8 7.8 0.2 2.7 2 1 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) HTH_25 PF13413.6 ACT03110.1 - 0.031 14.1 0.1 0.063 13.1 0.1 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain Phage_holin_3_6 PF07332.11 ACT03111.1 - 0.024 14.7 0.3 0.031 14.3 0.3 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2417 PF10329.9 ACT03111.1 - 0.067 12.6 0.2 0.074 12.5 0.2 1.1 1 0 0 1 1 1 0 Region of unknown function (DUF2417) Ctr PF04145.15 ACT03111.1 - 0.068 13.8 0.1 0.092 13.4 0.1 1.2 1 0 0 1 1 1 0 Ctr copper transporter family DUF4133 PF13571.6 ACT03111.1 - 0.16 12.3 0.7 0.2 12.0 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4133) ATPgrasp_YheCD PF14398.6 ACT03112.1 - 1.6e-81 273.3 0.0 2.1e-81 273.0 0.0 1.1 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACT03112.1 - 3.5e-09 36.3 0.1 0.00038 19.8 0.1 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp GSH-S_ATP PF02955.16 ACT03112.1 - 0.00013 21.4 0.0 0.065 12.6 0.0 3.3 1 1 2 3 3 3 1 Prokaryotic glutathione synthetase, ATP-grasp domain TTL PF03133.15 ACT03112.1 - 0.00018 20.8 0.0 0.00063 19.0 0.0 1.8 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family DUF1870 PF08965.10 ACT03112.1 - 0.12 12.4 0.1 0.31 11.1 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1870) ATPgrasp_YheCD PF14398.6 ACT03113.1 - 1.2e-81 273.8 0.0 1.4e-81 273.5 0.0 1.1 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACT03113.1 - 4.8e-05 22.8 0.0 0.073 12.3 0.0 2.8 2 1 0 2 2 2 2 Sugar-transfer associated ATP-grasp TTL PF03133.15 ACT03113.1 - 0.0018 17.4 0.0 0.1 11.7 0.0 2.3 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATP-grasp_3 PF02655.14 ACT03113.1 - 0.013 15.5 0.0 3 7.9 0.0 2.3 2 0 0 2 2 2 0 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ACT03113.1 - 0.25 10.9 0.0 0.4 10.2 0.0 1.2 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus ATPgrasp_YheCD PF14398.6 ACT03114.1 - 4.6e-84 281.7 0.0 6.3e-84 281.2 0.0 1.2 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACT03114.1 - 1.7e-05 24.2 0.0 0.027 13.7 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 ACT03115.1 - 2.8e-84 282.4 0.0 3.4e-84 282.1 0.0 1.1 1 0 0 1 1 1 1 YheC/D like ATP-grasp GSH-S_ATP PF02955.16 ACT03115.1 - 0.044 13.2 0.0 0.081 12.3 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain ATPgrasp_ST PF14397.6 ACT03115.1 - 0.13 11.5 0.0 1.6 7.9 0.0 2.1 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Acetyltransf_1 PF00583.25 ACT03116.1 - 3.2e-06 27.4 0.0 4.6e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT03116.1 - 2.1e-05 24.9 0.0 3.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT03116.1 - 0.00013 21.9 0.0 0.00016 21.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT03116.1 - 0.0028 17.6 0.0 0.0046 16.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ACT03116.1 - 0.068 13.8 0.0 0.13 13.0 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain SLH PF00395.20 ACT03117.1 - 2.8e-08 33.6 0.4 0.0029 17.6 0.0 3.1 2 1 0 2 2 2 2 S-layer homology domain Response_reg PF00072.24 ACT03118.1 - 5.4e-28 97.4 0.0 8.8e-28 96.7 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT03118.1 - 4.7e-27 93.9 0.0 8.5e-27 93.0 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal GerE PF00196.19 ACT03118.1 - 0.038 13.5 0.0 0.67 9.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HATPase_c PF02518.26 ACT03119.1 - 7.8e-29 100.5 0.0 1.5e-28 99.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT03119.1 - 1.2e-16 60.5 0.3 3e-16 59.2 0.0 1.8 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT03119.1 - 1.3e-14 54.3 0.0 2.8e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 ACT03119.1 - 3e-06 27.1 0.0 6.7e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT03119.1 - 8.1e-05 22.5 0.1 0.00038 20.3 0.0 2.1 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.6 ACT03119.1 - 0.0014 18.6 0.0 0.0031 17.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain DUF713 PF05218.14 ACT03119.1 - 0.029 14.1 0.2 0.05 13.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF713) DUF2451 PF10474.9 ACT03119.1 - 0.054 13.3 0.0 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) DUF3135 PF11333.8 ACT03119.1 - 0.5 10.6 2.8 1.4 9.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) TarH PF02203.15 ACT03119.1 - 1.6 8.7 8.1 0.75 9.7 0.1 2.9 3 0 0 3 3 3 0 Tar ligand binding domain homologue HAD_2 PF13419.6 ACT03120.1 - 4.2e-20 72.6 0.0 4.9e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT03120.1 - 6.7e-16 59.2 0.2 8.4e-16 58.9 0.2 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT03120.1 - 9.3e-15 55.5 1.4 2.3e-13 50.9 1.4 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ACT03120.1 - 4.8e-06 26.6 0.0 0.089 12.9 0.0 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT03120.1 - 0.00012 22.0 0.1 0.00023 21.2 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_3 PF08282.12 ACT03120.1 - 0.0032 17.2 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 ACT03120.1 - 0.0047 16.8 0.0 1.6 8.6 0.0 2.3 2 0 0 2 2 2 2 Acid Phosphatase Acid_phosphat_B PF03767.14 ACT03120.1 - 0.059 12.9 0.6 2.1 7.9 0.1 2.3 2 1 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) OpuAC PF04069.12 ACT03121.1 - 5e-69 232.7 7.4 5.8e-69 232.5 7.4 1.0 1 0 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system BPD_transp_1 PF00528.22 ACT03122.1 - 4e-25 88.6 8.6 4e-25 88.6 8.6 2.3 2 0 0 2 2 2 2 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 ACT03123.1 - 1.7e-34 119.3 0.1 3e-34 118.5 0.1 1.4 1 0 0 1 1 1 1 ABC transporter CBS PF00571.28 ACT03123.1 - 8.2e-12 45.4 0.1 0.00011 22.5 0.0 2.7 2 0 0 2 2 2 2 CBS domain AAA_21 PF13304.6 ACT03123.1 - 5.6e-05 23.1 0.1 0.044 13.6 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ACT03123.1 - 0.00023 21.4 0.4 0.0014 18.9 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT03123.1 - 0.0008 19.8 0.1 0.0018 18.7 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT03123.1 - 0.00093 18.9 0.1 0.0017 18.1 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT03123.1 - 0.0019 18.1 0.0 0.0038 17.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 ACT03123.1 - 0.01 16.4 0.0 0.023 15.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 ACT03123.1 - 0.015 14.1 0.4 2.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_30 PF13604.6 ACT03123.1 - 0.023 14.4 0.0 0.049 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ACT03123.1 - 0.027 14.9 0.1 0.23 11.9 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Adeno_IVa2 PF02456.15 ACT03123.1 - 0.034 12.9 0.0 0.055 12.2 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_23 PF13476.6 ACT03123.1 - 0.052 14.1 0.1 0.11 12.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF3987 PF13148.6 ACT03123.1 - 0.053 12.5 0.0 0.18 10.8 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3987) MMR_HSR1 PF01926.23 ACT03123.1 - 0.067 13.3 0.1 0.12 12.4 0.1 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase SbcCD_C PF13558.6 ACT03123.1 - 0.073 13.3 0.1 0.17 12.1 0.1 1.6 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ATPase_2 PF01637.18 ACT03123.1 - 0.093 12.6 0.3 0.54 10.1 0.3 2.1 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 ACT03123.1 - 0.11 12.7 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ACT03123.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DXP_redisom_C PF08436.12 ACT03123.1 - 0.15 12.2 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain G-alpha PF00503.20 ACT03123.1 - 0.22 10.7 0.1 0.55 9.3 0.0 1.5 1 1 1 2 2 2 0 G-protein alpha subunit SMC_N PF02463.19 ACT03123.1 - 0.46 9.9 1.9 10 5.4 1.9 2.3 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain Phage_rep_O PF04492.13 ACT03124.1 - 0.032 14.8 0.0 0.71 10.5 0.0 2.2 2 0 0 2 2 2 0 Bacteriophage replication protein O HTH_IclR PF09339.10 ACT03124.1 - 0.082 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain MmoB_DmpM PF02406.17 ACT03124.1 - 0.083 13.1 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 MmoB/DmpM family TrmB PF01978.19 ACT03124.1 - 0.12 12.3 0.0 3.8 7.5 0.0 2.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_18 PF12833.7 ACT03125.1 - 5.5e-19 68.2 0.1 1.1e-18 67.3 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain Peripla_BP_2 PF01497.18 ACT03125.1 - 4.6e-18 65.6 0.0 7.4e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein HTH_AraC PF00165.23 ACT03125.1 - 5e-14 52.0 0.0 7.4e-10 38.7 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Peripla_BP_2 PF01497.18 ACT03126.1 - 2.6e-24 86.1 0.1 3.3e-24 85.7 0.1 1.2 1 0 0 1 1 1 1 Periplasmic binding protein SAM_3 PF18016.1 ACT03126.1 - 0.068 13.0 0.0 12 5.8 0.0 3.2 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) Hexapep PF00132.24 ACT03127.1 - 3.2e-15 55.2 8.5 5.7e-12 44.9 3.1 3.8 4 0 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACT03127.1 - 1.3e-13 50.5 3.3 1.8e-11 43.6 2.9 3.2 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 ACT03127.1 - 5.3e-12 45.8 0.7 2.7e-11 43.5 0.7 2.0 2 0 0 2 2 2 1 Maltose acetyltransferase MatE PF01554.18 ACT03128.1 - 1.3e-33 115.9 33.3 2.7e-24 85.6 17.1 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 ACT03128.1 - 2.6e-06 27.5 7.5 2.6e-06 27.5 7.5 3.9 2 2 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain GWT1 PF06423.12 ACT03128.1 - 0.43 10.7 7.7 1.6 8.8 7.7 2.1 1 1 0 1 1 1 0 GWT1 DUF5408 PF17402.2 ACT03128.1 - 6.3 6.8 8.4 2.7 7.9 0.2 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5408) HTH_18 PF12833.7 ACT03129.1 - 4.6e-16 58.9 0.0 1e-15 57.7 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03129.1 - 5e-11 42.4 0.2 1.4e-06 28.3 0.1 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03129.1 - 4.8e-09 36.2 0.1 1.5e-08 34.6 0.0 1.7 1 1 1 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT03129.1 - 8.1e-09 35.1 0.0 1.4e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Cupin domain MannoseP_isomer PF01050.18 ACT03129.1 - 0.076 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Intg_mem_TP0381 PF09529.10 ACT03130.1 - 6.4e-59 199.2 22.4 7.6e-59 198.9 22.4 1.0 1 0 0 1 1 1 1 Integral membrane protein (intg_mem_TP0381) TMEM164 PF14808.6 ACT03130.1 - 0.022 14.1 7.3 0.017 14.5 6.0 1.4 1 1 0 1 1 1 0 TMEM164 family DUF4179 PF13786.6 ACT03131.1 - 7.5e-15 55.2 1.5 1.9e-14 53.9 0.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4179) DUF5643 PF18705.1 ACT03131.1 - 1e-06 28.7 6.8 0.0094 15.9 0.3 2.8 2 1 0 2 2 2 2 Family of unknown function (DUF5643) ETRAMP PF09716.10 ACT03131.1 - 0.061 13.4 0.6 0.2 11.8 0.4 1.9 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF3989 PF13150.6 ACT03131.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) Sigma70_r4_2 PF08281.12 ACT03132.1 - 2.1e-13 49.7 0.0 4.5e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT03132.1 - 1.4e-12 46.9 0.4 6e-12 44.9 0.0 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACT03132.1 - 2.6e-10 39.9 0.2 4.1e-10 39.3 0.2 1.3 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_ECF PF07638.11 ACT03132.1 - 0.00018 21.5 0.5 0.001 19.0 0.5 1.9 1 1 0 1 1 1 1 ECF sigma factor DUF3881 PF12997.7 ACT03132.1 - 0.029 13.6 0.7 0.073 12.3 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3881) LysR_substrate PF03466.20 ACT03133.1 - 7.3e-40 136.6 0.0 1e-39 136.1 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT03133.1 - 1.5e-19 69.7 0.2 3e-19 68.7 0.2 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 ACT03133.1 - 0.04 13.0 0.0 0.28 10.3 0.0 2.0 2 0 0 2 2 2 0 PBP superfamily domain GerA PF03323.13 ACT03134.1 - 1.5e-176 587.5 0.3 1.7e-176 587.3 0.3 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_permease PF03845.13 ACT03135.1 - 1.8e-43 148.6 30.8 2.3e-43 148.2 30.8 1.2 1 0 0 1 1 1 1 Spore germination protein VirB8 PF04335.13 ACT03135.1 - 0.27 11.0 0.7 0.56 10.0 0.7 1.5 1 0 0 1 1 1 0 VirB8 protein Spore_GerAC PF05504.11 ACT03136.1 - 1.1e-27 97.3 0.1 1.4e-27 96.9 0.1 1.2 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal Cation_efflux PF01545.21 ACT03137.1 - 1e-48 165.8 8.3 1.2e-48 165.5 8.3 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ACT03137.1 - 1.5e-17 63.5 0.8 3.3e-17 62.4 0.8 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DsbD_2 PF13386.6 ACT03137.1 - 0.0018 18.3 0.8 0.84 9.5 0.1 2.6 1 1 1 2 2 2 2 Cytochrome C biogenesis protein transmembrane region DUF996 PF06195.13 ACT03137.1 - 0.047 14.0 6.0 0.078 13.3 4.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF996) DUF3180 PF11377.8 ACT03137.1 - 0.44 10.7 4.8 2.4 8.3 0.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3180) Epimerase PF01370.21 ACT03138.1 - 1e-23 84.1 1.2 4.3e-22 78.8 0.4 2.5 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ACT03138.1 - 1.4e-22 80.0 0.2 2e-22 79.6 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 ACT03138.1 - 1.1e-16 61.1 0.0 1.3e-10 41.3 0.1 3.3 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ACT03138.1 - 1.9e-13 50.7 0.2 4.9e-13 49.4 0.1 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 ACT03138.1 - 3.6e-11 42.7 0.1 3.7e-10 39.4 0.1 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ACT03138.1 - 1.4e-09 37.5 1.4 8e-09 35.0 0.2 2.3 2 1 1 3 3 3 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ACT03138.1 - 3.9e-07 29.5 0.0 0.0028 16.9 0.0 3.0 2 1 1 3 3 3 2 Male sterility protein adh_short PF00106.25 ACT03138.1 - 2.4e-06 27.2 1.2 9.4e-06 25.2 1.3 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT03138.1 - 9.3e-05 22.4 0.2 0.0095 15.9 0.2 2.5 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 ACT03138.1 - 0.00011 21.8 0.1 0.00025 20.7 0.1 1.6 1 0 0 1 1 1 1 NmrA-like family adh_short_C2 PF13561.6 ACT03138.1 - 0.0013 18.3 0.7 0.004 16.7 0.4 1.9 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Glyco_transf_4 PF13439.6 ACT03138.1 - 0.013 15.5 0.1 0.4 10.7 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase Family 4 DapB_N PF01113.20 ACT03138.1 - 0.03 14.5 0.5 0.09 12.9 0.5 1.9 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus UDPG_MGDP_dh_C PF03720.15 ACT03138.1 - 0.043 14.2 0.0 0.083 13.3 0.0 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain F420_oxidored PF03807.17 ACT03138.1 - 0.097 13.3 0.1 0.31 11.7 0.0 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Ldh_1_N PF00056.23 ACT03138.1 - 0.11 12.6 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Aldo_ket_red PF00248.21 ACT03139.1 - 8.7e-69 231.9 0.0 9.7e-69 231.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Sacchrp_dh_NADP PF03435.18 ACT03139.1 - 0.023 14.9 0.0 0.95 9.7 0.0 2.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain HxlR PF01638.17 ACT03140.1 - 5.2e-28 96.7 0.1 5.9e-28 96.6 0.1 1.0 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.14 ACT03140.1 - 0.0037 17.2 0.0 0.0056 16.6 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family MarR PF01047.22 ACT03140.1 - 0.0039 17.1 0.1 0.0063 16.4 0.1 1.3 1 0 0 1 1 1 1 MarR family Leu_zip PF15294.6 ACT03140.1 - 0.1 12.1 0.0 0.11 12.0 0.0 1.0 1 0 0 1 1 1 0 Leucine zipper DUF1349 PF07081.11 ACT03141.1 - 2.7e-48 164.0 0.1 3.1e-48 163.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) Beta-lactamase PF00144.24 ACT03142.1 - 7.2e-62 209.5 0.1 8.6e-62 209.3 0.1 1.0 1 0 0 1 1 1 1 Beta-lactamase DUF347 PF03988.12 ACT03146.1 - 2.4e-41 139.7 36.1 2.1e-12 47.0 5.9 4.1 4 0 0 4 4 4 4 Repeat of Unknown Function (DUF347) DUF347 PF03988.12 ACT03147.1 - 2.7e-58 194.0 42.8 3.3e-17 62.4 2.5 4.4 4 0 0 4 4 4 4 Repeat of Unknown Function (DUF347) DUF4363 PF14276.6 ACT03147.1 - 0.0012 18.9 0.2 0.0022 18.1 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4363) Phage_holin_3_6 PF07332.11 ACT03147.1 - 0.21 11.6 0.1 0.21 11.6 0.1 3.6 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Phosphoesterase PF04185.14 ACT03148.1 - 1.3e-32 113.3 7.2 3.2e-29 102.2 1.9 3.0 1 1 1 2 2 2 2 Phosphoesterase family Sulfatase PF00884.23 ACT03148.1 - 0.00065 19.2 0.1 0.0012 18.3 0.0 1.5 2 0 0 2 2 2 1 Sulfatase YusW PF14039.6 ACT03149.1 - 1.3e-16 60.8 6.0 1.3e-16 60.8 6.0 2.8 2 1 1 3 3 3 1 YusW-like protein A_thal_3526 PF09713.10 ACT03149.1 - 0.01 16.0 0.0 0.03 14.6 0.0 1.8 1 0 0 1 1 1 0 Plant protein 1589 of unknown function (A_thal_3526) TRAM PF01938.20 ACT03149.1 - 0.14 12.2 0.7 2.1 8.4 0.0 2.3 1 1 1 2 2 2 0 TRAM domain Pyr_redox_dim PF02852.22 ACT03149.1 - 0.4 11.0 2.0 1.7 8.9 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain HlyIII PF03006.20 ACT03150.1 - 4e-36 124.8 27.4 4.7e-36 124.6 27.4 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF3087 PF11286.8 ACT03150.1 - 0.093 12.2 0.0 0.2 11.1 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3087) DUF1572 PF07609.11 ACT03152.1 - 2.8e-21 76.0 2.0 3.1e-19 69.4 2.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1572) DinB_2 PF12867.7 ACT03152.1 - 0.0006 20.3 0.0 0.0015 19.0 0.0 1.6 1 1 0 1 1 1 1 DinB superfamily DUF664 PF04978.12 ACT03152.1 - 0.0055 17.1 0.0 0.027 14.9 0.0 1.9 1 1 0 2 2 2 1 Protein of unknown function (DUF664) DUF2183 PF09949.9 ACT03152.1 - 0.062 13.6 0.0 0.085 13.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) HTH_46 PF15977.5 ACT03152.1 - 0.074 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA binding DUF1048 PF06304.11 ACT03153.1 - 2e-36 124.6 0.0 2.2e-36 124.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1048) DUF1048 PF06304.11 ACT03154.1 - 6.4e-37 126.1 0.0 7.3e-37 125.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1048) AcylCoA_dehyd_C PF12186.8 ACT03154.1 - 0.049 13.7 0.0 0.061 13.4 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal PadR PF03551.14 ACT03155.1 - 7.1e-23 80.4 0.0 9.7e-23 79.9 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family TrmB PF01978.19 ACT03155.1 - 0.007 16.2 0.0 0.1 12.5 0.0 2.1 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB Uroplakin_II PF07353.12 ACT03155.1 - 0.037 13.5 0.0 0.045 13.2 0.0 1.1 1 0 0 1 1 1 0 Uroplakin II Str_synth PF03088.16 ACT03156.1 - 0.0003 20.8 0.0 0.00039 20.5 0.0 1.1 1 0 0 1 1 1 1 Strictosidine synthase DUF4987 PF16377.5 ACT03156.1 - 0.039 14.1 0.0 0.041 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function LysR_substrate PF03466.20 ACT03157.1 - 4.2e-44 150.4 1.1 5.3e-44 150.1 1.1 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT03157.1 - 6e-21 74.2 0.8 1.4e-20 73.0 0.2 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 ACT03157.1 - 0.0092 15.8 0.9 0.02 14.8 0.2 1.9 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_30 PF13556.6 ACT03157.1 - 0.065 13.1 0.1 0.17 11.7 0.1 1.7 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain MFS_1 PF07690.16 ACT03158.1 - 2.5e-41 141.8 50.8 1.6e-39 135.8 35.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT03158.1 - 1.8e-08 33.7 33.8 1.6e-07 30.6 10.7 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.6 ACT03158.1 - 3.1e-05 22.7 21.0 0.00011 20.9 20.1 2.1 1 1 0 1 1 1 1 MFS/sugar transport protein MFS_1_like PF12832.7 ACT03158.1 - 0.0033 16.4 2.1 0.0033 16.4 2.1 2.7 1 1 1 2 2 2 1 MFS_1 like family DUF4006 PF13179.6 ACT03158.1 - 0.23 11.4 0.6 0.67 9.9 0.6 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF4006) OATP PF03137.20 ACT03158.1 - 2.8 6.1 9.7 1.4 7.1 0.1 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family MerR_1 PF13411.6 ACT03159.1 - 2.3e-15 56.4 0.5 4.9e-14 52.2 0.0 2.0 1 1 1 2 2 2 1 MerR HTH family regulatory protein MerR PF00376.23 ACT03159.1 - 3e-14 52.5 0.0 4.7e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 MerR family regulatory protein Nitroreductase PF00881.24 ACT03160.1 - 6e-29 101.3 0.1 1e-28 100.6 0.1 1.3 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 ACT03160.1 - 6.4e-08 32.4 0.7 0.00012 21.7 0.1 3.3 2 1 2 4 4 4 3 Putative TM nitroreductase HATPase_c PF02518.26 ACT03161.1 - 3.4e-14 53.3 0.0 5.5e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT03161.1 - 9e-14 51.3 0.1 2.9e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT03161.1 - 3.1e-09 37.1 0.0 5.9e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 HAMP domain HATPase_c_5 PF14501.6 ACT03161.1 - 3.4e-07 30.1 0.2 8.5e-07 28.8 0.0 1.7 2 0 0 2 2 2 1 GHKL domain CARD PF00619.21 ACT03161.1 - 0.017 15.1 0.2 0.22 11.6 0.0 2.7 3 0 0 3 3 3 0 Caspase recruitment domain Response_reg PF00072.24 ACT03162.1 - 7.8e-31 106.6 1.5 1.2e-30 106.0 1.5 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT03162.1 - 3.5e-27 94.3 0.0 6.8e-27 93.4 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal GerE PF00196.19 ACT03162.1 - 0.0038 16.7 0.1 0.027 14.0 0.0 2.2 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family HTH_24 PF13412.6 ACT03162.1 - 0.018 14.6 0.0 4.6 6.9 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding RrnaAD PF00398.20 ACT03163.1 - 1.2e-08 34.3 0.1 2e-08 33.7 0.1 1.7 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 ACT03163.1 - 1.9e-08 34.9 0.0 2.9e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ACT03163.1 - 1.2e-07 31.4 0.0 1.7e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 ACT03163.1 - 2.1e-06 28.4 0.0 3.1e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ACT03163.1 - 4e-06 26.3 0.0 5.2e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 ACT03163.1 - 4.2e-06 26.6 0.0 7.1e-06 25.9 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT03163.1 - 4.2e-06 27.3 0.0 6.5e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ACT03163.1 - 6.2e-05 22.8 0.1 0.00012 21.9 0.1 1.6 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 ACT03163.1 - 0.00013 21.8 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ACT03163.1 - 0.00045 19.6 0.0 0.00072 18.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 ACT03163.1 - 0.0013 18.5 0.0 0.0016 18.2 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase TrkA_N PF02254.18 ACT03163.1 - 0.0035 17.6 0.0 0.005 17.1 0.0 1.2 1 0 0 1 1 1 1 TrkA-N domain Methyltransf_PK PF05891.12 ACT03163.1 - 0.0078 15.7 0.0 0.011 15.2 0.0 1.3 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Cons_hypoth95 PF03602.15 ACT03163.1 - 0.018 14.7 0.0 0.024 14.3 0.0 1.1 1 0 0 1 1 1 0 Conserved hypothetical protein 95 TRM13 PF05206.14 ACT03163.1 - 0.079 12.5 0.1 0.11 12.0 0.1 1.3 1 1 0 1 1 1 0 Methyltransferase TRM13 Methyltransf_32 PF13679.6 ACT03163.1 - 0.086 12.8 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 ACT03163.1 - 0.13 12.3 0.0 0.32 11.1 0.0 1.7 1 1 0 1 1 1 0 FtsJ-like methyltransferase MarR PF01047.22 ACT03165.1 - 1.3e-10 41.1 0.0 2.1e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT03165.1 - 2.9e-08 33.5 0.0 4.3e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 MarR family Fe_dep_repress PF01325.19 ACT03165.1 - 0.00026 21.1 0.0 0.00044 20.4 0.0 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain LexA_DNA_bind PF01726.16 ACT03165.1 - 0.0014 18.3 0.0 0.0062 16.3 0.0 2.1 1 1 0 1 1 1 1 LexA DNA binding domain Penicillinase_R PF03965.16 ACT03165.1 - 0.0038 17.6 0.0 0.0078 16.6 0.0 1.7 1 1 0 1 1 1 1 Penicillinase repressor RNA_pol_Rpc34 PF05158.12 ACT03165.1 - 0.0046 16.4 0.2 0.0072 15.7 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit HTH_6 PF01418.17 ACT03165.1 - 0.012 15.5 0.5 0.096 12.7 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family HTH_Crp_2 PF13545.6 ACT03165.1 - 0.025 14.5 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_24 PF13412.6 ACT03165.1 - 0.025 14.1 0.0 0.063 12.8 0.0 1.8 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding TrmB PF01978.19 ACT03165.1 - 0.033 14.1 0.1 0.092 12.6 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 ACT03165.1 - 0.039 13.8 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain FeoC PF09012.10 ACT03165.1 - 0.05 13.7 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator SieB PF14163.6 ACT03165.1 - 0.3 10.6 2.3 0.47 9.9 0.6 2.0 1 1 1 2 2 2 0 Super-infection exclusion protein B Amidohydro_1 PF01979.20 ACT03166.1 - 1.3e-27 97.1 0.0 1.1e-26 94.0 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ACT03166.1 - 9.7e-16 58.3 0.5 2.2e-10 40.6 0.0 2.3 2 1 0 2 2 2 2 Amidohydrolase family Glyoxalase_4 PF13669.6 ACT03167.1 - 2.7e-09 37.3 0.0 3.2e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 ACT03167.1 - 0.0021 18.2 0.0 0.0027 17.9 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 ACT03167.1 - 0.0055 16.9 0.0 0.0076 16.4 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily WYL PF13280.6 ACT03167.1 - 0.079 13.0 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 WYL domain ABC2_membrane_3 PF12698.7 ACT03168.1 - 0.17 11.0 0.1 0.21 10.6 0.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein RibD_C PF01872.17 ACT03169.1 - 6.6e-25 88.1 0.0 9e-25 87.7 0.0 1.2 1 0 0 1 1 1 1 RibD C-terminal domain ProRS-C_2 PF09181.10 ACT03169.1 - 0.014 15.5 1.0 0.041 14.0 0.1 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal Acetyltransf_1 PF00583.25 ACT03170.1 - 1.2e-06 28.7 0.0 1.7e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT03170.1 - 0.0042 17.5 0.0 0.0075 16.7 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT03170.1 - 0.021 14.8 0.0 0.045 13.7 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain CNP_C_terminal PF17839.1 ACT03170.1 - 0.021 15.6 1.8 0.076 13.8 1.8 2.0 1 1 0 1 1 1 0 C-terminal domain of cyclic nucleotide phosphodiesterase Acetyltransf_16 PF05301.11 ACT03170.1 - 0.03 14.1 0.0 0.046 13.5 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 DUF3141 PF11339.8 ACT03170.1 - 0.066 11.6 0.3 0.093 11.1 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) MFS_1 PF07690.16 ACT03171.1 - 1.1e-57 195.6 43.1 1.1e-57 195.6 43.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2976 PF11190.8 ACT03171.1 - 4.4 7.2 8.7 0.7 9.7 1.6 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) PhoLip_ATPase_C PF16212.5 ACT03171.1 - 7.3 6.3 19.4 0.046 13.5 5.9 3.0 2 1 1 3 3 3 0 Phospholipid-translocating P-type ATPase C-terminal HTH_5 PF01022.20 ACT03172.1 - 1.3e-07 31.3 0.0 2e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACT03172.1 - 1.5e-05 25.0 0.0 2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 ACT03172.1 - 0.023 14.5 0.0 0.033 14.1 0.0 1.2 1 0 0 1 1 1 0 MarR family TrmB PF01978.19 ACT03172.1 - 0.051 13.5 0.0 0.082 12.8 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB ATP-grasp_2 PF08442.10 ACT03172.1 - 0.056 13.0 0.0 0.059 12.9 0.0 1.1 1 0 0 1 1 1 0 ATP-grasp domain COOH-NH2_lig PF14395.6 ACT03172.1 - 0.058 12.6 0.0 0.068 12.4 0.0 1.1 1 0 0 1 1 1 0 Phage phiEco32-like COOH.NH2 ligase-type 2 MarR PF01047.22 ACT03172.1 - 0.078 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 MarR family Acetyltransf_3 PF13302.7 ACT03173.1 - 1.4e-21 77.6 0.1 1.7e-21 77.3 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ACT03173.1 - 8.2e-07 29.3 0.1 1.1e-06 28.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT03173.1 - 2.1e-05 24.8 0.0 3e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family DUF2339 PF10101.9 ACT03175.1 - 0.00032 19.4 3.7 0.00037 19.2 3.7 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2339) Wzy_C PF04932.15 ACT03175.1 - 0.35 10.5 4.7 2 8.0 4.7 2.0 1 1 0 1 1 1 0 O-Antigen ligase Exosortase_EpsH PF09721.10 ACT03175.1 - 0.38 10.2 7.6 0.51 9.8 7.6 1.2 1 0 0 1 1 1 0 Transmembrane exosortase (Exosortase_EpsH) MatE PF01554.18 ACT03176.1 - 9.7e-37 126.1 35.5 4e-25 88.3 13.9 2.5 2 1 1 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ACT03176.1 - 1.2e-06 28.7 6.1 1.2e-06 28.7 6.1 4.2 3 1 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain Hexapep PF00132.24 ACT03177.1 - 2.3e-13 49.3 15.6 1.4e-11 43.6 6.5 3.8 4 0 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACT03177.1 - 1e-11 44.3 10.8 7.5e-11 41.6 6.0 3.3 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 ACT03177.1 - 2.5e-11 43.6 0.4 5.7e-11 42.5 0.4 1.6 1 0 0 1 1 1 1 Maltose acetyltransferase HTH_AraC PF00165.23 ACT03178.1 - 2.7e-24 84.7 0.7 2.2e-12 46.7 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT03178.1 - 3.3e-23 81.8 0.1 8.7e-23 80.4 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT03178.1 - 1.4e-17 63.8 0.0 2.4e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_Crp_2 PF13545.6 ACT03178.1 - 0.024 14.6 0.0 0.11 12.5 0.0 2.1 1 1 1 2 2 2 0 Crp-like helix-turn-helix domain CorA PF01544.18 ACT03179.1 - 1.3e-65 221.7 4.8 2.1e-65 221.0 4.8 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 ACT03179.1 - 0.025 13.4 0.3 0.031 13.0 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LcrR PF09621.10 ACT03179.1 - 0.048 13.1 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Type III secretion system regulator (LcrR) His_Phos_1 PF00300.22 ACT03180.1 - 6.8e-44 149.9 0.0 8.3e-44 149.6 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PI-PLC-X PF00388.19 ACT03180.1 - 0.014 14.9 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain His_Phos_2 PF00328.22 ACT03180.1 - 0.025 14.0 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Ribonuc_red_lgN PF00317.21 ACT03180.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribonucleotide reductase, all-alpha domain DUF4585 PF15232.6 ACT03181.1 - 0.08 13.0 0.0 1.7 8.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4585) Glyoxalase PF00903.25 ACT03182.1 - 2.6e-05 24.4 0.1 4.9e-05 23.5 0.1 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Methyltrans_RNA PF04452.14 ACT03182.1 - 0.035 13.4 0.0 0.043 13.1 0.0 1.2 1 0 0 1 1 1 0 RNA methyltransferase Glyoxalase_6 PF18029.1 ACT03182.1 - 0.16 12.8 0.0 0.16 12.8 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain AHSA1 PF08327.11 ACT03183.1 - 4.3e-21 75.4 0.7 5.3e-21 75.1 0.7 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ACT03183.1 - 0.004 17.4 1.7 0.0079 16.5 1.7 1.6 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sigma70_r2 PF04542.14 ACT03184.1 - 4e-20 71.3 0.2 1e-19 70.1 0.1 1.7 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT03184.1 - 2e-16 59.4 0.0 4.5e-16 58.3 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT03184.1 - 2.4e-06 26.9 0.0 6.1e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 NTF2 PF02136.20 ACT03184.1 - 0.00014 22.4 0.0 0.00027 21.5 0.0 1.4 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL_2 PF12680.7 ACT03184.1 - 0.00017 22.2 0.0 0.00039 21.0 0.0 1.7 1 0 0 1 1 1 1 SnoaL-like domain HTH_23 PF13384.6 ACT03184.1 - 0.014 15.2 0.0 0.041 13.7 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain SnoaL_4 PF13577.6 ACT03184.1 - 0.018 15.1 0.0 0.037 14.2 0.0 1.4 1 0 0 1 1 1 0 SnoaL-like domain HTH_29 PF13551.6 ACT03184.1 - 0.03 14.4 0.1 0.24 11.4 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn helix HTH_11 PF08279.12 ACT03184.1 - 0.033 14.1 0.1 0.06 13.3 0.1 1.4 1 0 0 1 1 1 0 HTH domain HBM PF16591.5 ACT03184.1 - 0.061 12.7 1.0 0.089 12.2 1.0 1.2 1 0 0 1 1 1 0 Helical bimodular sensor domain DUF4440 PF14534.6 ACT03184.1 - 0.073 13.5 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Sigma70_ECF PF07638.11 ACT03184.1 - 0.078 12.9 0.3 0.14 12.0 0.1 1.5 2 0 0 2 2 2 0 ECF sigma factor SnoaL_3 PF13474.6 ACT03184.1 - 0.095 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain MarR_2 PF12802.7 ACT03184.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 ACT03184.1 - 0.16 11.5 0.1 0.29 10.7 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF5348 PF17295.2 ACT03185.1 - 0.016 15.1 0.0 0.031 14.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5348) Flt3_lig PF02947.14 ACT03185.1 - 0.069 13.3 0.0 0.3 11.3 0.0 1.9 1 1 1 2 2 2 0 flt3 ligand RHH_3 PF12651.7 ACT03185.1 - 0.12 12.3 0.3 19 5.3 0.1 2.4 2 0 0 2 2 2 0 Ribbon-helix-helix domain DUF1918 PF08940.11 ACT03186.1 - 0.055 13.1 0.0 0.096 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) DUF4830 PF16112.5 ACT03187.1 - 6.4e-08 33.0 3.0 7.3e-07 29.6 3.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4830) DUF4972 PF16342.5 ACT03187.1 - 0.013 15.2 0.1 0.022 14.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4972) DUF2606 PF10794.9 ACT03187.1 - 0.014 15.1 0.2 0.024 14.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2606) Imm53 PF15580.6 ACT03187.1 - 0.06 13.0 0.5 0.085 12.6 0.5 1.5 1 1 0 1 1 1 0 Immunity protein 53 UPF0158 PF03682.13 ACT03188.1 - 4.3e-13 49.5 6.7 1.1e-11 44.9 6.7 2.0 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0158) Lar_restr_allev PF14354.6 ACT03189.1 - 0.062 13.7 0.8 0.099 13.0 0.1 1.7 2 0 0 2 2 2 0 Restriction alleviation protein Lar XAF1_C PF18608.1 ACT03189.1 - 0.094 12.3 4.3 1.9 8.1 0.3 2.7 3 0 0 3 3 3 0 XIAP-associated factor 1 C-terminal domain DUF1462 PF07315.11 ACT03190.1 - 0.09 13.1 0.1 0.095 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) DUF3885 PF13021.6 ACT03191.1 - 5e-17 61.7 2.3 1.2e-16 60.5 2.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3885) BRCT PF00533.26 ACT03192.1 - 0.047 14.1 0.0 0.056 13.8 0.0 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain DUF4585 PF15232.6 ACT03193.1 - 0.08 13.0 0.0 1.7 8.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4585) MscS_TM PF12794.7 ACT03194.1 - 0.024 13.5 0.5 0.029 13.2 0.5 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 FabA PF07977.13 ACT03195.1 - 5.3e-29 100.6 0.0 6.1e-29 100.4 0.0 1.0 1 0 0 1 1 1 1 FabA-like domain MaoC_dehydratas PF01575.19 ACT03195.1 - 9.3e-05 22.0 0.1 0.00025 20.6 0.0 1.7 1 1 1 2 2 2 1 MaoC like domain 4HBT PF03061.22 ACT03195.1 - 0.0088 16.4 0.0 0.017 15.4 0.0 1.6 1 1 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 ACT03195.1 - 0.019 15.4 0.0 0.025 15.1 0.0 1.3 1 0 0 1 1 1 0 Thioesterase-like superfamily V-set_2 PF15910.5 ACT03197.1 - 0.061 13.4 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 ICOS V-set domain CSD PF00313.22 ACT03198.1 - 2.7e-32 110.4 2.5 2.9e-32 110.3 2.5 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 ACT03198.1 - 0.0049 16.5 1.4 0.0075 15.9 1.4 1.6 1 1 0 1 1 1 1 Ribonuclease B OB domain Nitroreductase PF00881.24 ACT03199.1 - 1.8e-27 96.5 0.0 2.5e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 ACT03199.1 - 0.00016 21.3 0.0 0.53 9.8 0.0 2.2 2 0 0 2 2 2 2 Putative TM nitroreductase MFS_1 PF07690.16 ACT03200.1 - 2.7e-48 164.7 46.7 2.7e-48 164.7 46.7 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 ACT03200.1 - 2.7e-07 29.8 30.2 0.00065 18.7 8.0 2.3 2 0 0 2 2 2 2 MFS_1 like family DSBA PF01323.20 ACT03201.1 - 6.6e-45 153.3 0.0 7.7e-45 153.1 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 ACT03201.1 - 2e-10 41.0 0.2 1e-08 35.6 0.2 2.2 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 ACT03201.1 - 0.0001 22.3 0.0 0.0087 16.1 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_5 PF13743.6 ACT03201.1 - 0.00081 19.1 0.0 0.0017 18.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ACT03201.1 - 0.02 15.3 0.3 0.7 10.4 0.3 2.4 1 1 0 1 1 1 0 Thioredoxin-like domain GFO_IDH_MocA PF01408.22 ACT03202.1 - 5.3e-21 75.7 0.1 9.1e-21 74.9 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ACT03202.1 - 0.00027 21.6 0.0 0.00049 20.7 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain CoA_binding_2 PF13380.6 ACT03202.1 - 0.018 15.5 0.2 0.036 14.6 0.2 1.5 1 0 0 1 1 1 0 CoA binding domain TetR_N PF00440.23 ACT03203.1 - 1.8e-14 53.2 0.1 3.2e-14 52.4 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_Tnp_1_2 PF13022.6 ACT03203.1 - 0.0044 17.2 0.0 0.0077 16.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase HTH_23 PF13384.6 ACT03203.1 - 0.0068 16.2 0.6 0.017 14.9 0.1 2.0 3 0 0 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.6 ACT03203.1 - 0.012 15.7 0.3 0.027 14.6 0.3 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_38 PF13936.6 ACT03203.1 - 0.022 14.5 0.1 0.074 12.8 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain ThylakoidFormat PF11264.8 ACT03203.1 - 0.031 14.0 0.4 0.061 13.0 0.4 1.4 1 0 0 1 1 1 0 Thylakoid formation protein DUF4487 PF14868.6 ACT03203.1 - 0.038 12.8 0.0 0.042 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) HTH_6 PF01418.17 ACT03203.1 - 0.1 12.6 0.0 0.38 10.8 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family HTH_7 PF02796.15 ACT03203.1 - 0.16 12.1 0.2 0.43 10.7 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase DEDD_Tnp_IS110 PF01548.17 ACT03204.1 - 4.2e-31 107.9 0.0 8.5e-31 106.9 0.0 1.5 1 0 0 1 1 1 1 Transposase Transposase_20 PF02371.16 ACT03204.1 - 2.5e-17 63.0 0.9 4.1e-17 62.3 0.2 1.8 2 0 0 2 2 2 1 Transposase IS116/IS110/IS902 family CoA_binding_2 PF13380.6 ACT03204.1 - 0.13 12.7 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 CoA binding domain SSPI PF14098.6 ACT03205.1 - 0.066 13.4 0.1 0.095 12.9 0.1 1.3 1 0 0 1 1 1 0 Small, acid-soluble spore protein I Barstar PF01337.18 ACT03206.1 - 1.3e-06 28.3 0.0 2.1e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Barstar (barnase inhibitor) AHSA1 PF08327.11 ACT03207.1 - 1.8e-18 67.0 0.1 2.1e-18 66.7 0.1 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ACT03207.1 - 0.0024 18.2 0.2 0.0097 16.2 0.2 1.8 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AAA_30 PF13604.6 ACT03208.1 - 0.00025 20.8 0.0 0.00034 20.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ACT03208.1 - 0.00036 20.8 0.1 0.00049 20.4 0.1 1.5 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ACT03208.1 - 0.00056 19.7 0.0 0.00071 19.4 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 ACT03208.1 - 0.00063 19.9 0.1 0.00066 19.9 0.1 1.2 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 ACT03208.1 - 0.00071 19.1 0.0 0.00071 19.1 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 ACT03208.1 - 0.0014 19.2 0.0 0.0014 19.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT03208.1 - 0.0015 18.9 0.0 0.0026 18.2 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain 6PF2K PF01591.18 ACT03208.1 - 0.0016 17.8 0.0 0.0025 17.1 0.0 1.4 2 0 0 2 2 2 1 6-phosphofructo-2-kinase DUF2075 PF09848.9 ACT03208.1 - 0.0043 16.3 0.0 0.0045 16.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Thymidylate_kin PF02223.17 ACT03208.1 - 0.0057 16.4 0.0 0.011 15.4 0.0 1.4 1 1 0 1 1 1 1 Thymidylate kinase SRP54 PF00448.22 ACT03208.1 - 0.011 15.3 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Mg_chelatase PF01078.21 ACT03208.1 - 0.012 15.1 0.0 0.021 14.2 0.0 1.4 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 ACT03208.1 - 0.013 15.4 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 NTPase RcbX PF02341.15 ACT03208.1 - 0.016 15.5 0.0 0.021 15.1 0.0 1.1 1 0 0 1 1 1 0 RbcX protein MeaB PF03308.16 ACT03208.1 - 0.016 14.2 0.0 0.022 13.8 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 ACT03208.1 - 0.017 15.2 0.1 0.026 14.6 0.1 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain APS_kinase PF01583.20 ACT03208.1 - 0.018 14.9 0.0 0.025 14.4 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase Zeta_toxin PF06414.12 ACT03208.1 - 0.028 13.7 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 ACT03208.1 - 0.031 14.6 0.1 0.055 13.8 0.1 1.3 1 1 0 1 1 1 0 AAA domain MobB PF03205.14 ACT03208.1 - 0.051 13.5 0.0 0.051 13.5 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.12 ACT03208.1 - 0.075 13.0 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 NACHT domain AAA_11 PF13086.6 ACT03208.1 - 0.079 12.7 0.0 0.079 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ACT03208.1 - 0.087 13.2 0.0 0.09 13.2 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 ACT03208.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein T2SSE PF00437.20 ACT03208.1 - 0.12 11.4 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein CLP1_P PF16575.5 ACT03208.1 - 0.15 11.8 0.2 0.48 10.2 0.1 1.7 1 1 1 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_28 PF13521.6 ACT03208.1 - 0.19 12.0 0.3 0.2 11.9 0.3 1.3 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 ACT03208.1 - 0.2 12.1 0.0 0.3 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ACT03208.1 - 0.2 11.4 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain TauE PF01925.19 ACT03209.1 - 0.00036 20.2 3.8 0.00044 20.0 3.8 1.1 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Phage_holin_3_7 PF05449.11 ACT03209.1 - 0.021 14.8 1.7 0.031 14.3 1.7 1.4 1 1 0 1 1 1 0 Putative 3TM holin, Phage_holin_3 FUSC PF04632.12 ACT03209.1 - 0.19 10.2 3.0 0.23 10.0 3.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Ost4 PF10215.9 ACT03209.1 - 2.8 7.8 8.2 3.1 7.7 1.5 2.6 2 0 0 2 2 2 0 Oligosaccaryltransferase UPF0158 PF03682.13 ACT03210.1 - 4.3e-13 49.5 6.7 1.1e-11 44.9 6.7 2.0 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0158) XAF1_C PF18608.1 ACT03211.1 - 0.011 15.3 1.2 1.9 8.1 0.3 2.6 2 0 0 2 2 2 0 XIAP-associated factor 1 C-terminal domain Lar_restr_allev PF14354.6 ACT03211.1 - 0.063 13.7 0.8 0.099 13.0 0.1 1.7 2 0 0 2 2 2 0 Restriction alleviation protein Lar SnoaL_3 PF13474.6 ACT03212.1 - 0.0028 17.9 0.1 0.0053 17.0 0.1 1.4 1 1 0 1 1 1 1 SnoaL-like domain DUF4878 PF12870.7 ACT03212.1 - 0.0037 17.6 0.4 0.0048 17.2 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4878) DUF4101 PF13355.6 ACT03212.1 - 0.029 14.8 0.5 0.067 13.6 0.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4101) MlaC PF05494.12 ACT03212.1 - 0.038 13.8 0.3 0.1 12.3 0.3 1.8 1 1 0 1 1 1 0 MlaC protein DUF4999 PF16390.5 ACT03212.1 - 0.042 14.1 1.2 0.058 13.6 0.6 1.6 1 1 0 1 1 1 0 Domain of unknown function Lumazine_bd_2 PF12893.7 ACT03212.1 - 0.065 13.9 0.7 0.89 10.3 0.7 2.1 1 1 0 1 1 1 0 Putative lumazine-binding SnoaL_4 PF13577.6 ACT03212.1 - 0.08 13.1 0.0 0.44 10.7 0.0 1.9 2 0 0 2 2 2 0 SnoaL-like domain DUF4969 PF16339.5 ACT03212.1 - 0.13 12.6 1.7 0.22 11.9 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4969) VanZ PF04892.12 ACT03215.1 - 5.6e-18 65.8 9.2 6.3e-18 65.6 8.1 1.6 1 1 0 1 1 1 1 VanZ like family DUF5353 PF17304.2 ACT03215.1 - 0.05 13.3 0.2 0.097 12.4 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5353) SLH PF00395.20 ACT03216.1 - 5.7e-41 138.3 4.8 1.5e-15 56.9 0.2 3.8 3 0 0 3 3 3 3 S-layer homology domain Big_2 PF02368.18 ACT03216.1 - 1.5e-38 130.5 41.7 1.6e-09 37.5 1.5 7.3 8 0 0 8 8 8 6 Bacterial Ig-like domain (group 2) TMEM132 PF16070.5 ACT03216.1 - 0.0025 17.2 1.5 16 4.7 0.1 4.3 4 0 0 4 4 4 3 Transmembrane protein family 132 Mn_catalase PF05067.12 ACT03218.1 - 7.1e-76 254.9 0.1 1e-75 254.3 0.1 1.2 1 0 0 1 1 1 1 Manganese containing catalase Rubrerythrin PF02915.17 ACT03218.1 - 0.043 14.2 0.1 0.77 10.1 0.1 2.2 1 1 0 1 1 1 0 Rubrerythrin CotJB PF12652.7 ACT03219.1 - 1.3e-26 92.6 1.9 1.5e-26 92.4 1.9 1.1 1 0 0 1 1 1 1 CotJB protein CotJA PF11007.8 ACT03220.1 - 1.8e-11 43.6 0.8 3e-11 43.0 0.8 1.4 1 0 0 1 1 1 1 Spore coat associated protein JA (CotJA) Rick_17kDa_Anti PF05433.15 ACT03221.1 - 2.7e-05 23.9 23.2 2.7e-05 23.9 23.2 1.9 1 1 1 2 2 2 2 Glycine zipper 2TM domain DUF456 PF04306.13 ACT03221.1 - 0.0012 19.2 3.3 0.0013 19.0 3.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF456) Gly-zipper_Omp PF13488.6 ACT03221.1 - 0.013 15.5 24.4 0.015 15.3 23.2 1.7 1 1 0 1 1 1 0 Glycine zipper DUF3482 PF11981.8 ACT03221.1 - 0.061 12.7 5.4 0.064 12.6 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) TraT PF05818.12 ACT03221.1 - 0.096 12.4 4.1 0.11 12.2 4.1 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Bacteriocin_IIc PF10439.9 ACT03221.1 - 0.17 12.0 20.9 0.24 11.5 20.9 1.2 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide RTX PF02382.15 ACT03221.1 - 0.23 11.1 2.3 0.24 11.1 2.3 1.1 1 0 0 1 1 1 0 N-terminal domain in RTX protein DUF1269 PF06897.12 ACT03221.1 - 0.29 11.4 6.4 0.4 11.0 6.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) Gly-zipper_YMGG PF13441.6 ACT03221.1 - 0.41 10.4 25.4 0.79 9.5 25.4 1.6 1 1 0 1 1 1 0 YMGG-like Gly-zipper MccV PF17508.2 ACT03221.1 - 1.6 9.3 10.5 6 7.5 10.5 1.7 1 1 0 1 1 1 0 Microcin V bacteriocin CytB6-F_Fe-S PF08802.10 ACT03221.1 - 9.8 6.3 7.5 13 5.9 6.4 1.9 1 1 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit AI-2E_transport PF01594.16 ACT03222.1 - 2.7e-48 164.8 39.1 3.3e-48 164.5 39.1 1.0 1 0 0 1 1 1 1 AI-2E family transporter INTS5_C PF14838.6 ACT03222.1 - 0.043 12.4 0.3 0.061 12.0 0.3 1.2 1 0 0 1 1 1 0 Integrator complex subunit 5 C-terminus DUF2231 PF09990.9 ACT03222.1 - 2.4 8.6 7.3 0.52 10.8 2.2 2.5 2 1 0 2 2 2 0 Predicted membrane protein (DUF2231) YfkB PF08756.10 ACT03223.1 - 3.4e-76 254.2 0.1 5.3e-76 253.5 0.1 1.3 1 0 0 1 1 1 1 YfkB-like domain Radical_SAM PF04055.21 ACT03223.1 - 1.3e-14 55.0 0.0 2.8e-12 47.3 0.0 2.2 2 0 0 2 2 2 2 Radical SAM superfamily Fer4_12 PF13353.6 ACT03223.1 - 7.7e-06 26.2 0.0 2.1e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 ACT03223.1 - 0.00082 19.5 0.0 0.0027 17.8 0.0 1.9 1 0 0 1 1 1 1 4Fe-4S single cluster domain AP_endonuc_2 PF01261.24 ACT03223.1 - 0.1 12.0 0.0 11 5.4 0.0 2.7 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel HD PF01966.22 ACT03224.1 - 3.9e-15 56.2 0.1 6.4e-15 55.5 0.1 1.4 1 0 0 1 1 1 1 HD domain HD_5 PF13487.6 ACT03224.1 - 4.2e-14 52.5 0.0 1.1e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 ACT03224.1 - 0.023 14.2 0.1 0.058 12.9 0.1 1.7 1 1 0 1 1 1 0 HDOD domain SH3_18 PF18354.1 ACT03224.1 - 0.024 14.7 0.0 0.066 13.3 0.0 1.8 1 0 0 1 1 1 0 CarS bacterial SH3 domain 5_nucleotid_C PF02872.18 ACT03225.1 - 4.6e-20 72.4 0.0 1.1e-19 71.2 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 ACT03225.1 - 9.5e-09 36.0 0.0 1.5e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PGA_cap PF09587.10 ACT03225.1 - 1.9e-07 30.8 0.1 8.2e-07 28.7 0.1 1.9 1 1 0 1 1 1 1 Bacterial capsule synthesis protein PGA_cap YmdB PF13277.6 ACT03225.1 - 0.00081 18.8 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 YmdB-like protein Mob_synth_C PF06463.13 ACT03226.1 - 2.6e-34 117.9 0.0 5.3e-34 116.9 0.0 1.5 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 ACT03226.1 - 4.2e-32 111.8 0.0 6.7e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 ACT03226.1 - 5.2e-08 33.0 0.0 9.3e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 ACT03226.1 - 9.3e-08 32.4 0.0 1.6e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain MoaE PF02391.17 ACT03227.1 - 4.4e-33 113.9 0.3 7.2e-33 113.2 0.3 1.3 1 0 0 1 1 1 1 MoaE protein ThiS PF02597.20 ACT03227.1 - 1.5e-11 44.8 0.0 3.8e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 ThiS family HD PF01966.22 ACT03228.1 - 2.7e-18 66.3 0.1 4.4e-18 65.7 0.1 1.4 1 0 0 1 1 1 1 HD domain HD_5 PF13487.6 ACT03228.1 - 4e-10 39.8 0.1 9.2e-10 38.6 0.1 1.7 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 ACT03228.1 - 0.031 13.7 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 HDOD domain UPF0051 PF01458.17 ACT03229.1 - 9.5e-73 244.5 0.3 1.2e-72 244.1 0.3 1.1 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) NifU_N PF01592.16 ACT03230.1 - 7.3e-30 103.7 0.0 8e-29 100.4 0.0 1.9 1 1 0 1 1 1 1 NifU-like N terminal domain Aminotran_5 PF00266.19 ACT03231.1 - 1.3e-157 524.6 0.0 1.4e-157 524.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 ACT03231.1 - 1.7e-11 43.9 0.0 5e-11 42.4 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ACT03231.1 - 1.4e-10 40.3 1.1 6.6e-08 31.5 0.4 2.2 1 1 1 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 ACT03231.1 - 2.3e-07 30.4 0.1 3e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ACT03231.1 - 3.1e-07 30.0 1.8 4.7e-07 29.4 1.8 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 ACT03231.1 - 0.091 11.5 0.0 0.16 10.7 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain UPF0051 PF01458.17 ACT03232.1 - 9e-63 211.9 0.9 1.1e-62 211.5 0.2 1.5 2 0 0 2 2 2 1 Uncharacterized protein family (UPF0051) Tli4_C PF18426.1 ACT03232.1 - 0.082 13.2 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 Tle cognate immunity protein 4 C-terminal domain ABC_tran PF00005.27 ACT03233.1 - 4.4e-22 79.1 0.0 5.9e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT03233.1 - 2.1e-09 37.1 0.6 1.2e-08 34.7 0.6 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT03233.1 - 1.1e-06 28.7 0.0 0.039 13.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 ACT03233.1 - 1.3e-06 28.9 0.5 6.8e-05 23.3 0.5 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ACT03233.1 - 0.0002 21.6 0.1 0.013 15.7 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 ACT03233.1 - 0.0004 20.4 0.1 0.42 10.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ACT03233.1 - 0.00064 20.0 0.3 0.0033 17.7 0.3 2.0 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT03233.1 - 0.00073 19.5 0.1 0.0013 18.6 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ACT03233.1 - 0.0015 18.2 0.2 0.003 17.3 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ACT03233.1 - 0.0044 16.8 0.0 0.0053 16.5 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 ACT03233.1 - 0.0051 16.4 0.5 0.011 15.4 0.1 1.9 2 1 0 2 2 2 1 AAA domain AAA_13 PF13166.6 ACT03233.1 - 0.0051 15.5 0.0 0.17 10.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ACT03233.1 - 0.0054 17.3 0.6 0.043 14.4 0.6 2.6 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ACT03233.1 - 0.012 16.1 3.1 0.057 13.9 3.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_27 PF13514.6 ACT03233.1 - 0.016 14.8 0.1 0.028 14.0 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ACT03233.1 - 0.017 15.3 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ACT03233.1 - 0.02 14.6 0.1 0.03 14.0 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ACT03233.1 - 0.027 14.5 0.0 0.49 10.4 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 ACT03233.1 - 0.05 13.7 0.1 3.1 7.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) MMR_HSR1 PF01926.23 ACT03233.1 - 0.065 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 ACT03233.1 - 0.069 13.5 0.1 0.12 12.7 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 ACT03233.1 - 0.1 12.3 0.5 0.19 11.4 0.1 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF1802 PF08819.11 ACT03234.1 - 7.7e-64 214.7 0.2 9.5e-64 214.4 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1802) APH PF01636.23 ACT03235.1 - 3.9e-15 56.4 0.0 5.8e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family APH_6_hur PF04655.14 ACT03235.1 - 5.6e-05 22.6 0.0 0.0001 21.8 0.0 1.3 1 0 0 1 1 1 1 Aminoglycoside/hydroxyurea antibiotic resistance kinase Choline_kinase PF01633.20 ACT03235.1 - 0.043 13.4 0.0 0.083 12.5 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 ACT03235.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Fructosamine kinase IF-2B PF01008.17 ACT03236.1 - 1.6e-85 286.7 0.0 1.9e-85 286.5 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF1412 PF07203.11 ACT03236.1 - 0.18 12.0 0.0 0.39 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1412) DUF1805 PF08827.11 ACT03237.1 - 2.7e-23 82.1 1.0 3.7e-23 81.6 1.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1805) EAL PF00563.20 ACT03239.1 - 4e-79 265.5 0.0 1.1e-78 264.1 0.0 1.7 2 0 0 2 2 2 1 EAL domain GGDEF PF00990.21 ACT03239.1 - 2e-38 131.7 0.0 4e-38 130.7 0.0 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_4 PF08448.10 ACT03239.1 - 2.7e-11 43.7 0.0 8.7e-11 42.1 0.0 1.9 3 0 0 3 3 3 1 PAS fold PAS PF00989.25 ACT03239.1 - 3.4e-10 39.9 0.0 6.9e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ACT03239.1 - 1.2e-06 28.7 0.0 3.2e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 PAS domain SpoVT_C PF15714.5 ACT03239.1 - 0.043 13.9 0.0 0.15 12.2 0.0 1.9 1 1 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor YtpI PF14007.6 ACT03239.1 - 0.19 11.9 0.7 0.35 11.0 0.7 1.4 1 0 0 1 1 1 0 YtpI-like protein DUF3792 PF12670.7 ACT03239.1 - 0.25 11.5 2.3 0.44 10.7 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) DUF423 PF04241.15 ACT03240.1 - 5.7e-32 109.8 0.5 1e-31 108.9 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Yip1 PF04893.17 ACT03241.1 - 0.00048 19.9 6.6 0.00061 19.6 6.6 1.1 1 0 0 1 1 1 1 Yip1 domain CoatB PF10389.9 ACT03241.1 - 0.082 12.8 0.2 0.082 12.8 0.2 2.5 3 0 0 3 3 3 0 Bacteriophage coat protein B DUF2985 PF11204.8 ACT03241.1 - 1.4 9.1 5.2 0.2 11.8 1.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2985) DUF3810 PF12725.7 ACT03241.1 - 6.9 5.9 4.8 0.74 9.1 0.7 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF4064 PF13273.6 ACT03241.1 - 7.8 6.8 22.1 3.9 7.8 14.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) TRAF_BIRC3_bd PF16673.5 ACT03242.1 - 0.0045 16.7 4.5 0.34 10.7 0.2 3.1 2 0 0 2 2 2 2 TNF receptor-associated factor BIRC3 binding domain UPF0182 PF03699.13 ACT03242.1 - 0.034 12.3 4.5 0.17 10.0 4.4 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0182) Syntaxin-6_N PF09177.11 ACT03242.1 - 0.15 12.7 13.7 0.14 12.7 2.2 2.8 1 1 2 3 3 3 0 Syntaxin 6, N-terminal CLZ PF16526.5 ACT03242.1 - 0.55 10.6 8.0 1.5 9.3 1.5 3.6 2 2 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Las1 PF04031.13 ACT03242.1 - 5.2 7.2 6.9 3.5 7.7 4.5 2.0 1 1 1 2 2 2 0 Las1-like Exonuc_VII_L PF02601.15 ACT03242.1 - 6.2 6.3 20.5 5.4e+02 -0.1 20.5 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit SbcCD_C PF13558.6 ACT03243.1 - 5.5e-15 55.4 0.2 6.5e-14 51.9 0.1 2.7 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 ACT03243.1 - 9.1e-13 49.2 98.0 1.4e-06 29.0 66.8 6.6 1 1 2 3 3 3 1 AAA domain AAA_29 PF13555.6 ACT03243.1 - 1.8e-05 24.4 0.0 3.9e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 ACT03243.1 - 0.0057 16.1 0.0 0.0057 16.1 0.0 2.5 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_tran_CTD PF16326.5 ACT03243.1 - 0.0085 16.3 7.3 0.0085 16.3 7.3 10.4 4 3 4 10 10 9 1 ABC transporter C-terminal domain GTP_EFTU PF00009.27 ACT03243.1 - 0.061 12.9 0.5 0.37 10.3 0.0 2.6 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain RPW8 PF05659.11 ACT03243.1 - 0.063 13.0 16.4 4.7 6.9 0.2 4.8 3 2 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 AAA_15 PF13175.6 ACT03243.1 - 0.073 12.8 0.0 0.073 12.8 0.0 3.9 2 2 1 3 3 2 0 AAA ATPase domain ABC_tran PF00005.27 ACT03243.1 - 0.11 13.0 0.0 0.11 13.0 0.0 5.4 3 2 1 4 4 3 0 ABC transporter AAA_21 PF13304.6 ACT03243.1 - 0.14 11.9 0.1 0.98 9.2 0.0 2.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system FlaC_arch PF05377.11 ACT03243.1 - 1.2 9.6 26.8 1.5 9.3 0.5 6.6 7 0 0 7 7 7 0 Flagella accessory protein C (FlaC) Metallophos PF00149.28 ACT03244.1 - 3e-12 47.5 0.1 3.7e-12 47.2 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SbcD_C PF12320.8 ACT03244.1 - 1.3e-11 44.7 0.0 3.2e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Type 5 capsule protein repressor C-terminal domain Metallophos_2 PF12850.7 ACT03244.1 - 7.3e-07 29.5 5.3 4.7e-06 26.9 5.3 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MFS_1 PF07690.16 ACT03245.1 - 1.1e-36 126.5 53.1 1.5e-27 96.5 29.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT03245.1 - 0.36 9.6 31.9 0.28 10.0 18.1 2.7 1 1 0 2 2 2 0 Sugar (and other) transporter YpmT PF17431.2 ACT03245.1 - 3.1 7.9 8.8 18 5.4 0.0 3.7 3 0 0 3 3 3 0 Uncharacterized YmpT-like NAD_binding_10 PF13460.6 ACT03246.1 - 1.2e-25 90.4 0.3 1.4e-25 90.2 0.3 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT03246.1 - 3.3e-09 36.6 3.8 9.6e-09 35.1 3.4 1.8 2 0 0 2 2 2 1 NmrA-like family DapB_N PF01113.20 ACT03246.1 - 8e-05 22.8 1.4 0.00014 22.0 1.4 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 ACT03246.1 - 0.00021 20.9 0.4 0.00025 20.6 0.4 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 ACT03246.1 - 0.0073 16.7 0.9 0.22 11.9 1.3 2.4 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 ACT03246.1 - 0.013 14.6 0.7 0.033 13.3 0.2 2.0 2 1 0 2 2 2 0 RmlD substrate binding domain F420_oxidored PF03807.17 ACT03246.1 - 0.017 15.7 1.0 0.042 14.4 1.0 1.8 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DFP PF04127.15 ACT03246.1 - 0.03 14.2 0.2 0.061 13.2 0.2 1.5 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NAD_binding_7 PF13241.6 ACT03246.1 - 0.073 13.5 1.5 1.8 9.1 1.1 2.3 2 1 0 2 2 2 0 Putative NAD(P)-binding DJ-1_PfpI PF01965.24 ACT03246.1 - 0.084 12.7 0.3 0.34 10.7 0.1 2.0 1 1 1 2 2 2 0 DJ-1/PfpI family PglD_N PF17836.1 ACT03246.1 - 0.12 13.0 0.3 0.34 11.6 0.1 1.8 2 0 0 2 2 2 0 PglD N-terminal domain Rrf2 PF02082.20 ACT03247.1 - 5e-22 78.1 0.8 7.8e-22 77.4 0.1 1.6 2 0 0 2 2 2 1 Transcriptional regulator HrcA_DNA-bdg PF03444.15 ACT03247.1 - 0.001 18.7 0.0 0.0018 17.9 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HTH_Crp_2 PF13545.6 ACT03247.1 - 0.018 15.0 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain GntR PF00392.21 ACT03247.1 - 0.062 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_45 PF14947.6 ACT03247.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix Lactamase_B PF00753.27 ACT03248.1 - 4.4e-26 92.1 3.4 5.9e-26 91.7 3.4 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ACT03248.1 - 5.6e-06 26.0 0.2 9.7e-06 25.2 0.2 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 ACT03248.1 - 0.0012 18.4 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain EI24 PF07264.11 ACT03250.1 - 0.048 13.9 1.4 0.23 11.7 0.4 2.1 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) DeoRC PF00455.22 ACT03251.1 - 1.1e-41 142.5 0.1 1.6e-41 141.9 0.1 1.2 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 ACT03251.1 - 1.2e-17 63.4 0.3 2.4e-17 62.4 0.3 1.5 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACT03251.1 - 3.4e-09 36.5 0.2 9.3e-09 35.1 0.2 1.8 1 0 0 1 1 1 1 HTH domain Fe_dep_repress PF01325.19 ACT03251.1 - 1.2e-06 28.6 0.3 4.4e-06 26.8 0.2 1.9 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain HTH_20 PF12840.7 ACT03251.1 - 2.7e-06 27.3 0.1 5.3e-05 23.2 0.2 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain TrmB PF01978.19 ACT03251.1 - 4.3e-06 26.5 0.2 1.1e-05 25.2 0.2 1.7 2 0 0 2 2 1 1 Sugar-specific transcriptional regulator TrmB HTH_Mga PF08280.11 ACT03251.1 - 4.7e-06 26.5 0.3 1.6e-05 24.8 0.3 1.9 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_24 PF13412.6 ACT03251.1 - 8.2e-06 25.3 1.5 0.00042 19.8 0.3 2.4 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 ACT03251.1 - 9.1e-06 25.4 0.1 2e-05 24.3 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family GntR PF00392.21 ACT03251.1 - 1.4e-05 24.7 0.6 2.6e-05 23.8 0.6 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Ribosomal_S25 PF03297.15 ACT03251.1 - 2.7e-05 24.3 0.1 5.6e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 S25 ribosomal protein MarR_2 PF12802.7 ACT03251.1 - 7.6e-05 22.5 0.6 0.00019 21.2 0.2 1.8 2 0 0 2 2 1 1 MarR family Rrf2 PF02082.20 ACT03251.1 - 0.00033 21.0 0.1 0.00088 19.6 0.1 1.7 1 0 0 1 1 1 1 Transcriptional regulator MarR PF01047.22 ACT03251.1 - 0.00037 20.3 0.2 0.00092 19.1 0.2 1.6 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT03251.1 - 0.0009 19.7 0.2 0.0028 18.1 0.2 1.8 1 0 0 1 1 1 1 Winged helix DNA-binding domain TFIIE_alpha PF02002.17 ACT03251.1 - 0.0016 18.3 0.2 0.0029 17.4 0.2 1.3 1 0 0 1 1 1 1 TFIIE alpha subunit HemN_C PF06969.16 ACT03251.1 - 0.0022 18.0 0.2 0.01 15.9 0.1 2.0 2 0 0 2 2 2 1 HemN C-terminal domain HTH_34 PF13601.6 ACT03251.1 - 0.0059 16.8 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain Penicillinase_R PF03965.16 ACT03251.1 - 0.0068 16.8 0.4 0.013 15.9 0.4 1.4 1 0 0 1 1 1 1 Penicillinase repressor DUF4423 PF14394.6 ACT03251.1 - 0.0095 15.6 0.0 0.021 14.5 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4423) HTH_Crp_2 PF13545.6 ACT03251.1 - 0.013 15.5 0.2 0.029 14.3 0.2 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_12 PF08461.10 ACT03251.1 - 0.017 15.1 0.2 0.049 13.6 0.1 1.9 2 0 0 2 2 1 0 Ribonuclease R winged-helix domain DDRGK PF09756.9 ACT03251.1 - 0.027 14.1 0.2 0.049 13.2 0.2 1.4 1 0 0 1 1 1 0 DDRGK domain LexA_DNA_bind PF01726.16 ACT03251.1 - 0.058 13.2 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 LexA DNA binding domain DUF2250 PF10007.9 ACT03251.1 - 0.063 13.4 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) SgrR_N PF12793.7 ACT03251.1 - 0.065 13.5 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Sugar transport-related sRNA regulator N-term HTH_IclR PF09339.10 ACT03251.1 - 0.065 13.0 1.7 0.078 12.8 0.3 1.9 2 0 0 2 2 1 0 IclR helix-turn-helix domain HxlR PF01638.17 ACT03251.1 - 0.079 12.8 0.2 0.2 11.5 0.2 1.6 1 0 0 1 1 1 0 HxlR-like helix-turn-helix DprA_WH PF17782.1 ACT03251.1 - 0.085 13.0 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 DprA winged helix domain EAP30 PF04157.16 ACT03251.1 - 0.11 11.8 0.1 0.2 10.9 0.1 1.4 1 0 0 1 1 1 0 EAP30/Vps36 family FaeA PF04703.12 ACT03251.1 - 0.16 12.3 0.1 1.1 9.7 0.0 2.3 2 0 0 2 2 2 0 FaeA-like protein adh_short_C2 PF13561.6 ACT03252.1 - 9.5e-66 221.7 0.7 1.1e-65 221.5 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT03252.1 - 1.4e-52 178.0 2.8 1.7e-52 177.8 2.8 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT03252.1 - 1.3e-14 54.5 0.6 1.9e-14 54.0 0.6 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACT03252.1 - 4.8e-06 26.2 0.3 1.2e-05 24.9 0.3 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ACT03252.1 - 1.3e-05 24.6 0.9 1.6e-05 24.2 0.9 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 ACT03252.1 - 0.0012 18.2 0.3 0.041 13.2 0.2 2.3 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 ACT03252.1 - 0.0018 17.7 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) AraC_N PF06719.13 ACT03253.1 - 4.9e-49 165.8 0.2 7.8e-49 165.1 0.2 1.3 1 0 0 1 1 1 1 AraC-type transcriptional regulator N-terminus HTH_18 PF12833.7 ACT03253.1 - 3.5e-18 65.6 1.4 3.5e-18 65.6 1.4 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03253.1 - 1.6e-10 40.8 0.2 4.5e-06 26.6 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AHSA1 PF08327.11 ACT03254.1 - 1.3e-09 38.3 0.2 1.6e-09 38.1 0.2 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ACT03254.1 - 0.00031 21.0 0.0 0.00039 20.7 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport TetR_N PF00440.23 ACT03255.1 - 4.5e-12 45.6 0.1 1.1e-11 44.4 0.1 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family HTH_Tnp_1_2 PF13022.6 ACT03255.1 - 0.0016 18.6 0.7 0.0097 16.0 0.0 2.4 2 1 0 2 2 2 1 Helix-turn-helix of insertion element transposase HTH_23 PF13384.6 ACT03255.1 - 0.009 15.8 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain LacI PF00356.21 ACT03255.1 - 0.044 13.6 0.1 0.18 11.6 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family DUF3502 PF12010.8 ACT03256.1 - 5e-43 146.9 0.2 1.1e-42 145.7 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACT03256.1 - 1.2e-13 51.7 8.7 3.7e-13 50.1 8.7 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT03257.1 - 5.5e-09 36.0 30.9 5.8e-08 32.7 30.9 2.3 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT03258.1 - 2e-14 53.8 13.1 2e-14 53.8 13.1 2.4 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component HTH_18 PF12833.7 ACT03259.1 - 3.2e-20 72.2 0.2 6.2e-20 71.2 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03259.1 - 3.3e-20 71.7 0.2 2.2e-09 37.2 0.2 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Response_reg PF00072.24 ACT03259.1 - 6.5e-20 71.4 0.0 3.2e-19 69.1 0.0 2.2 2 0 0 2 2 2 1 Response regulator receiver domain Bac_thur_toxin PF01338.18 ACT03259.1 - 0.045 13.2 0.0 0.086 12.3 0.0 1.4 1 0 0 1 1 1 0 Bacillus thuringiensis toxin His_kinase PF06580.13 ACT03260.1 - 6.5e-23 80.8 3.4 6.5e-23 80.8 3.4 2.8 3 0 0 3 3 3 1 Histidine kinase HAMP PF00672.25 ACT03260.1 - 2.2e-06 28.0 0.0 6.7e-06 26.4 0.0 1.9 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT03260.1 - 0.0014 19.1 0.0 0.0029 18.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT03260.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain GxGYxYP_C PF14323.6 ACT03261.1 - 7.5e-69 232.3 4.6 1.1e-68 231.8 2.6 2.1 2 0 0 2 2 2 1 GxGYxYP putative glycoside hydrolase C-terminal domain GxGYxYP_N PF16216.5 ACT03261.1 - 1e-61 208.9 0.0 2.1e-61 207.9 0.0 1.5 1 0 0 1 1 1 1 GxGYxY sequence motif in domain of unknown function N-terminal Glyco_hydro_38N PF01074.22 ACT03263.1 - 1.2e-80 271.0 0.0 1.9e-80 270.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ACT03263.1 - 2.1e-44 152.2 0.0 3.7e-44 151.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ACT03263.1 - 3.1e-24 84.9 0.3 1e-23 83.3 0.3 1.9 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ACT03263.1 - 1e-11 44.8 0.0 2.6e-11 43.5 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_57 PF03065.15 ACT03263.1 - 2.7e-06 26.8 0.2 5.3e-06 25.9 0.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 DUF1579 PF07617.11 ACT03263.1 - 0.16 11.9 0.3 0.32 10.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1579) SBP_bac_1 PF01547.25 ACT03264.1 - 3.6e-35 122.4 12.9 3.6e-35 122.4 12.9 1.7 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT03264.1 - 2.3e-32 112.9 5.9 2.3e-32 112.9 5.9 1.7 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT03264.1 - 6.4e-08 32.3 1.7 0.00046 19.7 0.2 2.4 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT03265.1 - 1.2e-08 34.9 22.9 2.8e-08 33.7 22.8 1.8 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT03266.1 - 3.2e-09 36.8 30.9 2.3e-08 34.0 30.9 2.0 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Peripla_BP_3 PF13377.6 ACT03267.1 - 3.2e-28 99.1 0.0 1.1e-27 97.4 0.0 1.8 2 0 0 2 2 2 1 Periplasmic binding protein-like domain GntR PF00392.21 ACT03267.1 - 2.1e-15 56.1 0.0 4.3e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Peripla_BP_1 PF00532.21 ACT03267.1 - 4.1e-12 46.1 0.0 5.8e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT03267.1 - 5.8e-11 42.4 0.0 1.1e-10 41.6 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding protein domain HTH_11 PF08279.12 ACT03267.1 - 0.0012 18.8 0.0 0.003 17.5 0.0 1.7 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 ACT03267.1 - 0.004 17.1 0.0 0.015 15.3 0.0 2.0 2 0 0 2 2 2 1 MarR family HTH_DeoR PF08220.12 ACT03267.1 - 0.0078 15.9 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain CagD PF16567.5 ACT03267.1 - 0.02 14.7 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Pathogenicity island component CagD TrmB PF01978.19 ACT03267.1 - 0.032 14.1 0.0 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_36 PF13730.6 ACT03267.1 - 0.045 13.7 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain AbiEi_4 PF13338.6 ACT03267.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin MarR_2 PF12802.7 ACT03267.1 - 0.13 12.2 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 MarR family DUF4965 PF16335.5 ACT03268.1 - 3.8e-70 235.1 0.0 8.4e-70 233.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF5127 PF17168.4 ACT03268.1 - 9.8e-64 215.2 0.6 1.8e-63 214.4 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF1793 PF08760.11 ACT03268.1 - 9.8e-51 172.5 2.5 1.8e-50 171.6 2.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4964 PF16334.5 ACT03268.1 - 2.1e-20 72.1 0.0 4.5e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) Glyco_hydr_116N PF12215.8 ACT03268.1 - 0.013 15.0 0.1 0.037 13.5 0.1 1.8 1 1 0 1 1 1 0 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term SMP_LBD PF17047.5 ACT03268.1 - 0.11 12.0 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Synaptotagmin-like mitochondrial-lipid-binding domain TylF PF05711.11 ACT03269.1 - 2.8e-103 344.7 0.2 6.7e-102 340.1 0.2 1.9 1 1 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 ACT03269.1 - 8.8e-09 36.3 0.0 1.4e-08 35.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 ACT03269.1 - 0.0077 15.9 0.0 1 9.0 0.0 2.1 2 0 0 2 2 2 2 Cephalosporin hydroxylase ADP_ribosyl_GH PF03747.14 ACT03271.1 - 6.4e-56 190.2 7.7 5.7e-55 187.1 7.7 1.9 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase Rick_17kDa_Anti PF05433.15 ACT03271.1 - 7.9 6.4 16.7 2.6 8.0 0.5 3.1 3 0 0 3 3 3 0 Glycine zipper 2TM domain AAA_28 PF13521.6 ACT03272.1 - 6e-31 107.9 0.1 9.2e-31 107.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain CTP_transf_like PF01467.26 ACT03272.1 - 8.9e-06 25.9 0.0 3.1e-05 24.2 0.0 2.0 2 1 0 2 2 2 1 Cytidylyltransferase-like AAA_18 PF13238.6 ACT03272.1 - 0.0077 16.8 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Citrate_ly_lig PF08218.11 ACT03272.1 - 0.0091 15.7 0.0 0.026 14.2 0.0 1.7 2 0 0 2 2 2 1 Citrate lyase ligase C-terminal domain FAD_syn PF06574.12 ACT03272.1 - 0.016 15.1 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 FAD synthetase AAA_5 PF07728.14 ACT03272.1 - 0.026 14.5 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ACT03272.1 - 0.029 14.5 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 ACT03272.1 - 0.049 13.1 0.0 0.092 12.2 0.0 1.5 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA PF00004.29 ACT03272.1 - 0.07 13.6 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 ACT03272.1 - 0.075 12.6 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain NMN_transporter PF04973.12 ACT03273.1 - 1.6e-53 181.2 28.1 1.6e-53 181.2 28.1 1.3 2 0 0 2 2 2 1 Nicotinamide mononucleotide transporter DUF4293 PF14126.6 ACT03273.1 - 0.77 10.0 16.8 0.063 13.5 6.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4293) NUDIX PF00293.28 ACT03274.1 - 6.8e-18 65.0 0.5 1e-17 64.4 0.5 1.3 1 0 0 1 1 1 1 NUDIX domain DUF4011 PF13195.6 ACT03275.1 - 1e-44 152.3 1.6 3.1e-44 150.8 1.6 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF4011) MTES_1575 PF18741.1 ACT03275.1 - 5.8e-25 87.3 0.3 2.1e-24 85.5 0.0 2.1 2 0 0 2 2 1 1 REase_MTES_1575 AAA_11 PF13086.6 ACT03275.1 - 6.2e-18 65.5 2.1 1.3e-08 35.0 0.1 3.0 3 0 0 3 3 3 2 AAA domain DUF3320 PF11784.8 ACT03275.1 - 6.7e-18 64.4 0.1 1.3e-16 60.2 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3320) AAA_12 PF13087.6 ACT03275.1 - 3.1e-15 56.3 0.0 1.2e-14 54.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ACT03275.1 - 2.8e-11 43.5 0.7 3.8e-06 26.7 0.4 2.8 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 ACT03275.1 - 1.1e-07 32.3 0.0 0.00053 20.3 0.0 3.0 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 ACT03275.1 - 0.00018 21.3 0.0 0.083 12.6 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 ACT03275.1 - 0.0015 18.9 0.0 0.0015 18.9 0.0 3.0 3 0 0 3 3 1 1 AAA ATPase domain DUF559 PF04480.12 ACT03275.1 - 0.0016 18.3 0.0 0.0065 16.3 0.0 2.1 2 0 0 2 2 1 1 Protein of unknown function (DUF559) IstB_IS21 PF01695.17 ACT03275.1 - 0.0017 18.1 0.0 0.0057 16.4 0.0 1.8 2 0 0 2 2 1 1 IstB-like ATP binding protein Helicase_RecD PF05127.14 ACT03275.1 - 0.0024 17.7 0.1 0.1 12.5 0.1 2.7 2 0 0 2 2 2 1 Helicase UvrD-helicase PF00580.21 ACT03275.1 - 0.0038 16.8 0.3 0.28 10.7 0.1 3.4 3 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain Mg_chelatase PF01078.21 ACT03275.1 - 0.0071 15.7 0.1 0.016 14.6 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TrwB_AAD_bind PF10412.9 ACT03275.1 - 0.0073 15.3 0.0 0.019 13.9 0.0 1.6 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain ResIII PF04851.15 ACT03275.1 - 0.0084 16.1 0.0 0.11 12.5 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ACT03275.1 - 0.01 16.1 0.0 0.045 14.0 0.0 2.1 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 ACT03275.1 - 0.043 13.0 0.0 0.089 11.9 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 MeaB PF03308.16 ACT03275.1 - 0.085 11.8 0.1 0.19 10.7 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 ACT03275.1 - 0.12 12.8 0.5 0.6 10.5 0.0 2.6 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ACT03275.1 - 0.13 12.0 0.0 0.31 10.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.15 ACT03275.1 - 0.22 10.3 0.0 0.4 9.4 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein UreF PF01730.16 ACT03275.1 - 1.2 9.7 9.7 1.5 9.4 6.5 2.8 1 1 0 2 2 2 0 UreF DUF45 PF01863.17 ACT03276.1 - 5.9e-52 176.7 2.3 2.8e-50 171.3 2.3 2.0 1 1 0 1 1 1 1 Protein of unknown function DUF45 WLM PF08325.10 ACT03276.1 - 2.9e-07 30.7 0.4 6.6e-07 29.6 0.1 1.7 2 0 0 2 2 2 1 WLM domain DUF2268 PF10026.9 ACT03276.1 - 0.016 14.8 0.2 0.12 11.9 0.0 2.1 2 0 0 2 2 2 0 Predicted Zn-dependent protease (DUF2268) DUF2802 PF10975.8 ACT03276.1 - 0.018 15.1 1.0 0.04 14.0 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) Peptidase_M57 PF12388.8 ACT03276.1 - 0.066 12.8 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase SprT-like PF10263.9 ACT03276.1 - 0.11 12.4 0.2 0.27 11.1 0.0 1.7 2 0 0 2 2 2 0 SprT-like family FGE-sulfatase PF03781.16 ACT03277.1 - 1.1e-53 182.5 10.5 4.9e-53 180.4 10.5 1.9 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Glyco_hydro_11 PF00457.17 ACT03278.1 - 6.1e-70 234.5 22.1 7.1e-70 234.2 22.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Glyco_hydro_59 PF02057.15 ACT03279.1 - 9.3e-97 323.8 5.6 1.7e-96 323.0 3.1 2.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 59 SLH PF00395.20 ACT03279.1 - 1.9e-34 117.4 2.6 1.5e-10 40.9 0.1 4.9 4 0 0 4 4 4 3 S-layer homology domain DUF5011 PF16403.5 ACT03279.1 - 4e-32 110.2 13.6 1.6e-15 57.0 2.1 3.8 2 0 0 2 2 2 2 Domain of unknown function (DUF5011) CE2_N PF17996.1 ACT03279.1 - 4.8e-07 29.7 1.3 0.012 15.5 0.3 3.9 2 1 1 3 3 3 2 Carbohydrate esterase 2 N-terminal FIVAR PF07554.13 ACT03279.1 - 3.9e-05 24.3 1.2 3.9e-05 24.3 1.2 3.5 3 0 0 3 3 3 1 FIVAR domain DUF1080 PF06439.11 ACT03279.1 - 0.00024 21.3 1.6 0.00098 19.3 0.1 2.9 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1080) Big_3_2 PF12245.8 ACT03279.1 - 0.00072 19.8 15.9 0.15 12.3 0.1 6.1 7 0 0 7 7 7 2 Bacterial Ig-like domain Big_4 PF07532.11 ACT03279.1 - 0.0026 17.5 4.7 0.0079 15.9 1.7 3.4 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 4) Glyco_hydro_30C PF17189.4 ACT03279.1 - 0.089 13.0 0.1 0.089 13.0 0.1 4.3 4 0 0 4 4 4 0 Glycosyl hydrolase family 30 beta sandwich domain DUF4625 PF15418.6 ACT03279.1 - 0.43 10.8 4.9 11 6.2 0.1 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4625) Vsr PF03852.15 ACT03280.1 - 1.7e-24 85.4 0.2 3.1e-24 84.6 0.2 1.4 1 0 0 1 1 1 1 DNA mismatch endonuclease Vsr MTES_1575 PF18741.1 ACT03280.1 - 0.00012 22.2 0.3 0.032 14.4 0.3 2.2 1 1 0 1 1 1 1 REase_MTES_1575 RtcB PF01139.17 ACT03281.1 - 1.1e-69 235.7 2.2 5e-69 233.5 2.2 1.8 1 1 0 1 1 1 1 tRNA-splicing ligase RtcB AUDH_Cupin PF18637.1 ACT03281.1 - 0.094 12.7 0.2 0.59 10.1 0.0 2.2 2 0 0 2 2 2 0 Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain Glyco_hydro_4C PF11975.8 ACT03282.1 - 4.7e-56 190.2 0.0 7.3e-56 189.5 0.0 1.3 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase C-terminal domain Glyco_hydro_4 PF02056.16 ACT03282.1 - 1.3e-48 165.0 0.1 1.8e-48 164.5 0.1 1.2 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase HTH_18 PF12833.7 ACT03283.1 - 1e-19 70.6 0.0 2e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03283.1 - 2e-16 59.6 0.0 4.3e-09 36.2 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT03283.1 - 1.6e-13 50.2 0.0 2.9e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACT03283.1 - 2.1e-12 47.1 0.0 3.3e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.12 ACT03283.1 - 6.5e-05 22.6 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_6 PF12852.7 ACT03283.1 - 0.00078 19.2 0.0 0.0013 18.5 0.0 1.5 1 1 0 1 1 1 1 Cupin AraC_binding_2 PF14525.6 ACT03283.1 - 0.0072 16.0 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 AraC-binding-like domain Pirin_C PF05726.13 ACT03283.1 - 0.0088 16.4 0.0 0.02 15.2 0.0 1.6 1 0 0 1 1 1 1 Pirin C-terminal cupin domain ARD PF03079.14 ACT03283.1 - 0.013 15.7 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 ARD/ARD' family Rrf2 PF02082.20 ACT03283.1 - 0.095 13.1 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 Transcriptional regulator BCAS2 PF05700.11 ACT03284.1 - 0.097 12.3 1.2 0.28 10.9 0.2 1.8 1 1 1 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) DUF1232 PF06803.12 ACT03285.1 - 2e-12 46.7 7.2 2.9e-12 46.2 7.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1232) OrfB_Zn_ribbon PF07282.11 ACT03285.1 - 0.0047 16.8 2.1 0.0047 16.8 2.1 2.0 2 0 0 2 2 2 1 Putative transposase DNA-binding domain Rtf2 PF04641.12 ACT03285.1 - 0.013 14.9 0.4 0.017 14.5 0.4 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Cytochrom_c3_2 PF14537.6 ACT03285.1 - 0.018 15.5 0.9 0.029 14.8 0.9 1.4 1 0 0 1 1 1 0 Cytochrome c3 Zn_Tnp_IS1595 PF12760.7 ACT03285.1 - 0.019 15.0 2.0 0.035 14.1 2.0 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 ACT03285.1 - 0.019 14.9 3.2 0.059 13.3 3.1 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 ACT03285.1 - 0.019 15.0 1.6 0.034 14.1 1.6 1.4 1 0 0 1 1 1 0 zinc-ribbons TF_Zn_Ribbon PF08271.12 ACT03285.1 - 0.036 13.6 0.5 0.075 12.6 0.5 1.6 1 1 0 1 1 1 0 TFIIB zinc-binding Mu-like_Com PF10122.9 ACT03285.1 - 0.075 12.5 1.7 0.23 10.9 1.6 1.8 1 1 1 2 2 2 0 Mu-like prophage protein Com Zn_Tnp_IS1 PF03811.13 ACT03285.1 - 0.093 12.5 0.2 0.2 11.4 0.2 1.5 1 0 0 1 1 1 0 InsA N-terminal domain zf-ribbon_3 PF13248.6 ACT03285.1 - 0.14 11.6 4.6 0.43 10.0 4.6 1.9 1 1 0 1 1 1 0 zinc-ribbon domain HypA PF01155.19 ACT03285.1 - 0.18 11.8 1.9 0.33 11.0 1.9 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 ACT03285.1 - 0.23 11.5 2.5 0.59 10.2 2.5 1.6 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 ACT03285.1 - 0.33 10.7 4.9 1.4 8.7 4.9 2.0 1 1 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 ACT03285.1 - 4.3 7.5 6.2 8 6.7 0.4 2.1 1 1 0 2 2 2 0 Zinc ribbon domain DUF5329 PF17263.2 ACT03286.1 - 0.0033 17.6 0.7 0.0038 17.4 0.7 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5329) Phage_HK97_TLTM PF06120.11 ACT03286.1 - 0.005 16.1 2.7 0.0051 16.1 2.7 1.0 1 0 0 1 1 1 1 Tail length tape measure protein FAM76 PF16046.5 ACT03286.1 - 0.046 13.1 3.0 0.053 12.9 3.0 1.0 1 0 0 1 1 1 0 FAM76 protein Atg14 PF10186.9 ACT03286.1 - 0.13 11.3 3.3 0.14 11.2 3.3 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.13 ACT03286.1 - 0.2 10.9 3.2 0.22 10.8 3.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.6 ACT03286.1 - 1.2 8.4 4.4 1.3 8.3 4.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XhlA PF10779.9 ACT03286.1 - 4.1 7.7 6.3 4.8 7.4 0.6 2.0 1 1 1 2 2 2 0 Haemolysin XhlA AMP-binding PF00501.28 ACT03287.1 - 3.2e-82 276.4 0.0 4e-82 276.1 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ACT03287.1 - 3.8e-24 85.5 0.3 8.2e-24 84.4 0.3 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Fic PF02661.18 ACT03289.1 - 2.7e-12 47.4 0.0 3.9e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Fic/DOC family Glyco_hydro_92 PF07971.12 ACT03290.1 - 1.4e-90 304.5 18.4 5.2e-88 296.0 18.4 3.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 92 CBM_6 PF03422.15 ACT03290.1 - 8.7e-75 249.0 48.1 4.9e-21 75.3 3.4 6.2 6 0 0 6 6 6 4 Carbohydrate binding module (family 6) Glyco_hydro_92N PF17678.1 ACT03290.1 - 2.7e-60 204.2 8.6 1e-59 202.4 6.3 3.0 3 0 0 3 3 3 1 Glycosyl hydrolase family 92 N-terminal domain F5_F8_type_C PF00754.25 ACT03290.1 - 1.2e-18 67.4 3.7 1.2e-18 67.4 3.7 5.2 4 1 1 5 5 5 1 F5/8 type C domain DUF5010_C PF18099.1 ACT03290.1 - 1.1e-12 48.0 22.6 9.4e-05 22.5 0.9 5.9 6 0 0 6 6 6 4 DUF5010 C-terminal domain BNR PF02012.20 ACT03290.1 - 0.62 10.3 6.4 0.82 9.9 0.4 3.5 2 0 0 2 2 2 0 BNR/Asp-box repeat SLH PF00395.20 ACT03291.1 - 2.6e-35 120.2 2.5 3.5e-13 49.3 0.1 3.6 3 0 0 3 3 3 3 S-layer homology domain FtsJ PF01728.19 ACT03291.1 - 0.052 13.7 0.0 0.19 11.9 0.0 1.9 2 0 0 2 2 2 0 FtsJ-like methyltransferase MG2 PF01835.19 ACT03291.1 - 0.11 13.0 0.2 0.41 11.1 0.0 2.1 2 0 0 2 2 2 0 MG2 domain PA14 PF07691.12 ACT03292.1 - 4.3e-23 81.7 0.3 2e-22 79.6 0.3 2.3 1 0 0 1 1 1 1 PA14 domain Metallophos PF00149.28 ACT03292.1 - 1.4e-17 64.9 2.6 1.4e-17 64.9 2.6 2.5 2 1 1 3 3 3 1 Calcineurin-like phosphoesterase F5_F8_type_C PF00754.25 ACT03292.1 - 1.5e-17 63.9 0.7 1.5e-17 63.9 0.7 3.6 3 0 0 3 3 3 1 F5/8 type C domain Pur_ac_phosph_N PF16656.5 ACT03292.1 - 4.1e-16 59.3 11.6 5e-14 52.6 0.1 4.7 3 1 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 ACT03292.1 - 2.2e-05 24.7 3.2 0.008 16.5 0.3 4.1 4 0 0 4 4 4 1 Fibronectin type III domain SWM_repeat PF13753.6 ACT03292.1 - 0.00017 21.6 0.2 0.00095 19.3 0.0 2.5 2 0 0 2 2 2 1 Putative flagellar system-associated repeat GLEYA PF10528.9 ACT03292.1 - 0.002 18.5 0.1 0.002 18.5 0.1 2.8 3 0 0 3 3 3 1 GLEYA domain PhoD_N PF16655.5 ACT03292.1 - 0.0027 18.2 0.3 0.032 14.8 0.0 3.0 2 0 0 2 2 2 1 PhoD-like phosphatase, N-terminal domain CHB_HEX_C PF03174.13 ACT03292.1 - 0.016 15.2 0.1 0.12 12.4 0.0 2.5 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain BNR PF02012.20 ACT03292.1 - 0.035 14.1 0.0 0.19 11.8 0.0 2.4 1 0 0 1 1 1 0 BNR/Asp-box repeat MTHFR PF02219.17 ACT03293.1 - 2.3e-08 33.7 0.0 1.7e-07 30.9 0.0 2.0 2 0 0 2 2 2 1 Methylenetetrahydrofolate reductase DUF1205 PF06722.12 ACT03293.1 - 0.0062 16.6 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1205) DUF402 PF04167.13 ACT03294.1 - 3.7e-14 52.7 0.1 5.7e-14 52.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF402) MLTD_N PF06474.12 ACT03295.1 - 0.027 14.7 0.6 0.049 13.8 0.6 1.4 1 0 0 1 1 1 0 MltD lipid attachment motif VCBS PF13517.6 ACT03295.1 - 0.036 14.7 0.1 0.41 11.3 0.0 2.8 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella SLH PF00395.20 ACT03296.1 - 2.9e-42 142.4 8.5 1.8e-15 56.6 0.2 4.9 4 0 0 4 4 4 3 S-layer homology domain LTD PF00932.19 ACT03296.1 - 2.2e-33 115.0 15.7 3e-11 43.7 0.3 5.2 4 0 0 4 4 4 3 Lamin Tail Domain Metallophos PF00149.28 ACT03296.1 - 1.1e-12 48.9 7.0 2.5e-12 47.7 7.0 1.7 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3416 PF11896.8 ACT03296.1 - 4.5e-05 23.8 0.0 0.034 14.4 0.0 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF3416) Metallophos_2 PF12850.7 ACT03296.1 - 0.0086 16.3 1.3 0.031 14.5 1.3 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Big_7 PF17957.1 ACT03296.1 - 0.012 16.4 0.5 0.012 16.4 0.5 9.9 8 2 2 10 10 10 0 Bacterial Ig domain CBM_3 PF00942.18 ACT03296.1 - 1.6 9.2 13.5 0.71 10.3 0.8 5.0 5 0 0 5 5 5 0 Cellulose binding domain HupE_UreJ_2 PF13795.6 ACT03297.1 - 6.1e-47 159.2 10.2 8.8e-47 158.6 10.2 1.2 1 0 0 1 1 1 1 HupE / UreJ protein EF-hand_5 PF13202.6 ACT03297.1 - 0.0022 17.4 0.1 0.0049 16.3 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 ACT03297.1 - 0.02 14.4 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 EF hand DUF5422 PF17459.2 ACT03297.1 - 0.05 13.8 0.9 0.12 12.6 0.9 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5422) AlaDh_PNT_C PF01262.21 ACT03298.1 - 2.3e-79 265.6 2.7 3.6e-79 265.0 2.7 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 ACT03298.1 - 1e-46 158.6 0.2 1.7e-46 157.9 0.2 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Shikimate_DH PF01488.20 ACT03298.1 - 5.5e-07 29.7 0.1 1.4e-06 28.4 0.1 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ACT03298.1 - 7.6e-07 29.6 1.5 5e-06 27.0 1.0 2.3 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 ACT03298.1 - 4.2e-06 26.8 0.2 9.5e-06 25.6 0.2 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ACT03298.1 - 1.4e-05 24.6 0.7 2.9e-05 23.5 0.1 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 ACT03298.1 - 1.7e-05 24.2 0.2 2.4e-05 23.7 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT03298.1 - 2.5e-05 24.7 0.5 7.1e-05 23.3 0.2 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_2 PF03446.15 ACT03298.1 - 4.1e-05 23.8 0.4 0.00036 20.8 0.2 2.3 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase THF_DHG_CYH_C PF02882.19 ACT03298.1 - 0.0011 18.3 0.9 0.0061 15.9 1.0 2.2 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TrkA_N PF02254.18 ACT03298.1 - 0.0015 18.7 0.6 0.0057 16.9 0.3 2.1 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_7 PF13241.6 ACT03298.1 - 0.002 18.6 1.1 0.006 17.0 0.2 2.2 3 0 0 3 3 3 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 ACT03298.1 - 0.0057 16.9 0.5 0.013 15.7 0.5 1.7 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ADH_zinc_N PF00107.26 ACT03298.1 - 0.0064 16.5 0.2 0.022 14.7 0.2 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase GIDA PF01134.22 ACT03298.1 - 0.14 11.2 0.6 0.21 10.6 0.6 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A PucR PF07905.11 ACT03299.1 - 3.9e-33 114.2 0.0 1.5e-32 112.3 0.0 2.0 3 0 0 3 3 3 1 Purine catabolism regulatory protein-like family HTH_30 PF13556.6 ACT03299.1 - 9.9e-16 57.3 0.4 1.9e-15 56.4 0.4 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain GGDEF_2 PF17853.1 ACT03299.1 - 0.05 13.9 0.0 0.13 12.5 0.0 1.8 2 0 0 2 2 2 0 GGDEF-like domain Amidohydro_1 PF01979.20 ACT03301.1 - 1.5e-26 93.6 0.0 2e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ACT03301.1 - 7.3e-18 65.3 1.5 1.1e-06 28.4 0.0 3.2 3 0 0 3 3 3 3 Amidohydrolase family Usp PF00582.26 ACT03301.1 - 0.094 13.2 0.1 0.19 12.2 0.1 1.5 1 0 0 1 1 1 0 Universal stress protein family DHO_dh PF01180.21 ACT03302.1 - 1.1e-32 113.5 0.2 1.7e-32 112.9 0.2 1.3 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase Fer4_21 PF14697.6 ACT03302.1 - 2.5e-23 82.0 13.9 4.5e-23 81.2 13.9 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Dus PF01207.17 ACT03302.1 - 1.7e-09 37.2 1.4 1.4e-08 34.2 0.1 2.1 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) Fer4 PF00037.27 ACT03302.1 - 2.5e-06 27.0 16.1 0.00017 21.2 4.0 2.7 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 ACT03302.1 - 4.1e-05 24.1 12.8 9.7e-05 22.9 12.8 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ACT03302.1 - 5.2e-05 23.3 8.6 0.0049 16.9 0.2 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 ACT03302.1 - 0.00058 19.8 21.4 0.0054 16.8 3.2 2.6 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 ACT03302.1 - 0.0026 17.9 12.6 0.029 14.5 13.4 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain HMGL-like PF00682.19 ACT03302.1 - 0.0078 15.8 0.7 0.011 15.3 0.0 1.5 2 0 0 2 2 2 1 HMGL-like Fer4_2 PF12797.7 ACT03302.1 - 0.055 13.6 12.7 0.051 13.7 2.2 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain NMO PF03060.15 ACT03302.1 - 0.089 12.2 3.7 0.31 10.4 2.5 2.2 2 1 0 2 2 2 0 Nitronate monooxygenase Fer4_16 PF13484.6 ACT03302.1 - 0.098 13.6 0.7 0.098 13.6 0.7 2.6 1 1 3 4 4 4 0 4Fe-4S double cluster binding domain PdxJ PF03740.13 ACT03302.1 - 0.13 11.4 0.0 0.48 9.5 0.0 1.8 1 1 0 2 2 2 0 Pyridoxal phosphate biosynthesis protein PdxJ Fer4_4 PF12800.7 ACT03302.1 - 0.75 10.5 16.0 2.2 9.0 2.7 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_8 PF13183.6 ACT03302.1 - 2.1 8.9 13.4 6.4 7.3 13.4 1.9 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 ACT03302.1 - 2.9 8.5 14.7 1 9.9 2.4 2.6 1 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_22 PF17179.4 ACT03302.1 - 6.1 7.8 12.9 4.8 8.1 2.9 2.4 1 1 2 3 3 3 0 4Fe-4S dicluster domain Fer4_20 PF14691.6 ACT03303.1 - 8.1e-40 135.1 2.4 1.3e-39 134.5 2.4 1.3 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 ACT03303.1 - 2.4e-36 125.5 6.2 3.3e-36 125.0 6.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACT03303.1 - 2.1e-15 56.8 1.4 7.5e-10 38.5 0.1 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT03303.1 - 1.2e-14 54.7 1.7 2.2e-06 28.2 0.0 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ACT03303.1 - 3.3e-08 33.6 1.2 2.6e-07 30.8 0.8 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ACT03303.1 - 3.7e-08 33.1 0.9 1.4e-06 27.9 0.2 2.8 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase AlaDh_PNT_C PF01262.21 ACT03303.1 - 1.3e-06 27.8 2.8 0.0078 15.5 0.4 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 ACT03303.1 - 3.4e-06 26.9 10.2 7.6e-06 25.7 0.7 3.4 3 1 0 4 4 4 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 ACT03303.1 - 5.7e-06 25.8 0.2 0.043 13.2 0.0 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HI0933_like PF03486.14 ACT03303.1 - 1.7e-05 23.7 5.2 0.00012 21.0 0.8 2.6 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_7 PF13241.6 ACT03303.1 - 2.7e-05 24.5 1.2 0.03 14.8 0.1 2.6 2 1 0 2 2 2 2 Putative NAD(P)-binding FAD_binding_3 PF01494.19 ACT03303.1 - 6.9e-05 22.2 0.7 0.00019 20.8 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 ACT03303.1 - 0.00011 21.6 2.4 0.00037 19.8 0.3 2.3 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.7 ACT03303.1 - 0.00011 21.7 5.6 0.00012 21.5 0.3 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 ACT03303.1 - 0.00018 20.7 5.1 0.0017 17.5 0.2 3.0 3 0 0 3 3 3 1 Glucose inhibited division protein A Shikimate_DH PF01488.20 ACT03303.1 - 0.0002 21.4 0.2 0.041 14.0 0.0 2.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 ACT03303.1 - 0.00024 20.3 1.3 0.00024 20.3 1.3 2.1 2 1 0 2 2 2 1 FAD binding domain PALP PF00291.25 ACT03303.1 - 0.00075 19.0 1.6 0.17 11.3 0.1 2.7 3 0 0 3 3 3 1 Pyridoxal-phosphate dependent enzyme K_oxygenase PF13434.6 ACT03303.1 - 0.0012 18.1 0.4 0.019 14.1 0.0 2.4 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 ACT03303.1 - 0.0015 17.0 0.2 0.9 7.9 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Fer4_7 PF12838.7 ACT03303.1 - 0.0094 16.5 0.5 0.0094 16.5 0.5 2.7 2 1 0 2 2 2 1 4Fe-4S dicluster domain ELFV_dehydrog PF00208.21 ACT03303.1 - 0.01 15.6 0.9 0.036 13.8 0.2 2.0 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_9 PF13454.6 ACT03303.1 - 0.01 15.8 3.0 0.099 12.6 0.2 3.2 4 1 1 5 5 5 0 FAD-NAD(P)-binding 3HCDH_N PF02737.18 ACT03303.1 - 0.017 15.0 0.5 0.41 10.5 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 ACT03303.1 - 0.022 13.8 0.4 0.022 13.8 0.4 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein F420_oxidored PF03807.17 ACT03303.1 - 0.027 15.1 3.7 12 6.6 0.0 4.4 4 1 0 4 4 3 0 NADP oxidoreductase coenzyme F420-dependent Tryp_inh PF17983.1 ACT03303.1 - 0.029 14.5 2.0 0.06 13.4 2.0 1.5 1 0 0 1 1 1 0 Trypsin inhibitors 1,2 and 3 IlvN PF07991.12 ACT03303.1 - 0.041 13.4 0.1 8.2 6.0 0.0 2.5 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ThiF PF00899.21 ACT03303.1 - 0.3 10.4 1.5 8.9 5.6 0.2 2.7 2 1 0 2 2 2 0 ThiF family Fer4_10 PF13237.6 ACT03303.1 - 0.83 9.8 9.7 4.9 7.4 9.7 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 ACT03303.1 - 2.7 8.2 8.2 0.54 10.5 1.2 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 ACT03303.1 - 6.2 7.1 13.0 0.99 9.6 3.2 2.7 2 1 0 2 2 2 0 4Fe-4S binding domain CN_hydrolase PF00795.22 ACT03304.1 - 9.5e-58 195.6 0.1 1.1e-57 195.4 0.1 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Peptidase_M20 PF01546.28 ACT03305.1 - 1.1e-25 90.6 0.0 1.5e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 ACT03305.1 - 1.6e-08 34.5 0.0 2.4e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 M20_dimer PF07687.14 ACT03305.1 - 9.1e-07 28.8 0.0 3.1e-06 27.0 0.0 1.9 1 1 1 2 2 2 1 Peptidase dimerisation domain NMT1 PF09084.11 ACT03306.1 - 2.5e-50 171.4 1.4 3.2e-50 171.0 1.4 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 ACT03306.1 - 5.9e-08 32.7 1.9 7.9e-06 25.7 0.1 2.9 2 1 1 3 3 3 2 NMT1-like family BPD_transp_1 PF00528.22 ACT03307.1 - 2.2e-18 66.7 19.3 3.8e-18 65.9 19.3 1.4 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT03308.1 - 8.5e-18 64.7 18.7 1.4e-17 64.0 18.7 1.4 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF1129 PF06570.11 ACT03308.1 - 1.2 8.6 6.0 0.22 11.0 1.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) ABC_tran PF00005.27 ACT03309.1 - 5.8e-33 114.3 0.0 8.7e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT03309.1 - 1.1e-08 35.3 0.2 0.0012 18.7 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT03309.1 - 9.6e-05 22.1 0.0 0.00042 20.0 0.0 2.1 3 0 0 3 3 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT03309.1 - 0.00014 22.3 0.1 0.00022 21.7 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 ACT03309.1 - 0.00026 20.5 0.0 0.033 13.6 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 ACT03309.1 - 0.00041 20.3 0.1 0.0028 17.6 0.0 2.0 2 0 0 2 2 2 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 ACT03309.1 - 0.00074 19.5 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA PF00004.29 ACT03309.1 - 0.00074 19.9 0.0 0.0059 17.0 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ACT03309.1 - 0.0019 18.5 0.0 0.0031 17.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ACT03309.1 - 0.0023 17.9 0.1 0.0091 16.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ACT03309.1 - 0.01 15.5 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein T2SSE PF00437.20 ACT03309.1 - 0.011 14.8 0.0 0.045 12.8 0.0 1.8 1 1 1 2 2 2 0 Type II/IV secretion system protein AAA_23 PF13476.6 ACT03309.1 - 0.014 15.9 0.0 0.021 15.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ACT03309.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ACT03309.1 - 0.019 15.3 0.0 0.056 13.8 0.0 1.9 2 1 0 2 2 2 0 RNA helicase ATPase_2 PF01637.18 ACT03309.1 - 0.023 14.6 0.1 0.18 11.7 0.0 2.2 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 ACT03309.1 - 0.036 13.6 0.0 0.27 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ACT03309.1 - 0.045 14.0 0.0 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC_ATPase PF09818.9 ACT03309.1 - 0.047 12.5 0.0 0.18 10.5 0.0 2.0 2 1 0 2 2 2 0 Predicted ATPase of the ABC class Zeta_toxin PF06414.12 ACT03309.1 - 0.047 13.0 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NB-ARC PF00931.22 ACT03309.1 - 0.11 11.7 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 ACT03309.1 - 0.12 12.9 0.0 0.29 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ACT03309.1 - 0.16 12.1 0.0 0.32 11.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ACT03309.1 - 0.16 11.7 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Glyco_hydro_2_C PF02836.17 ACT03310.1 - 9.5e-127 422.3 3.5 1.3e-126 421.9 3.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 ACT03310.1 - 1.1e-69 234.7 0.0 1.8e-69 234.1 0.0 1.3 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 ACT03310.1 - 6.4e-32 110.8 1.9 6.9e-32 110.7 0.5 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 ACT03310.1 - 1.4e-17 64.0 0.2 4.3e-17 62.4 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 ACT03310.1 - 6.8e-16 58.9 0.0 9.7e-15 55.2 0.0 2.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 ACT03310.1 - 0.014 15.9 0.0 0.047 14.3 0.0 1.9 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain BPD_transp_1 PF00528.22 ACT03311.1 - 4.7e-16 59.1 17.5 4.7e-16 59.1 17.5 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component ETRAMP PF09716.10 ACT03311.1 - 8.3 6.6 9.1 0.25 11.4 1.2 2.7 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) BPD_transp_1 PF00528.22 ACT03312.1 - 1.7e-17 63.8 28.1 5.5e-17 62.1 21.7 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_8 PF13416.6 ACT03313.1 - 5.9e-33 114.9 15.0 9.9e-33 114.2 15.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein LPAM_1 PF08139.12 ACT03313.1 - 0.54 10.9 3.5 0.9 10.2 3.5 1.4 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site His_kinase PF06580.13 ACT03314.1 - 8.2e-23 80.5 2.1 8.2e-23 80.5 2.1 1.9 2 0 0 2 2 1 1 Histidine kinase dCache_1 PF02743.18 ACT03314.1 - 1.4e-14 54.5 4.4 1.4e-14 54.5 4.4 2.3 2 0 0 2 2 2 1 Cache domain HAMP PF00672.25 ACT03314.1 - 4.6e-09 36.5 0.0 1.3e-08 35.1 0.0 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT03314.1 - 0.00071 20.1 1.0 0.0015 19.0 0.1 2.1 2 0 0 2 2 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AI-2E_transport PF01594.16 ACT03314.1 - 0.0011 18.2 1.1 0.0011 18.2 1.1 2.2 2 0 0 2 2 2 1 AI-2E family transporter TcdB_N PF12918.7 ACT03314.1 - 0.018 15.3 0.1 0.056 13.7 0.1 1.9 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain EcoEI_R_C PF08463.10 ACT03314.1 - 0.018 15.1 0.1 0.046 13.8 0.1 1.6 2 0 0 2 2 2 0 EcoEI R protein C-terminal UCH PF00443.29 ACT03314.1 - 0.039 13.5 0.5 0.064 12.7 0.5 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase IFRD PF05004.13 ACT03314.1 - 0.042 13.0 0.2 0.072 12.2 0.2 1.4 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) HATPase_c_2 PF13581.6 ACT03314.1 - 0.043 13.8 0.0 0.088 12.8 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain DUF996 PF06195.13 ACT03314.1 - 0.16 12.2 12.8 0.94 9.8 4.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF996) MitMem_reg PF13012.6 ACT03314.1 - 0.37 11.2 2.3 1.3 9.4 1.4 2.3 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function DUF4175 PF13779.6 ACT03314.1 - 0.8 7.5 4.6 1.2 7.0 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FtsL PF04999.13 ACT03314.1 - 2.5 8.2 8.1 1.6 8.8 1.4 2.6 2 0 0 2 2 2 0 Cell division protein FtsL DUF4179 PF13786.6 ACT03314.1 - 3.5 8.2 9.4 0.63 10.6 0.1 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4179) Response_reg PF00072.24 ACT03315.1 - 7.5e-26 90.5 0.3 2.1e-25 89.1 0.1 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT03315.1 - 2.8e-22 78.8 0.9 1.4e-20 73.3 0.2 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03315.1 - 1.5e-15 56.8 6.5 1.5e-09 37.7 0.1 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF444 PF04285.12 ACT03316.1 - 1.7e-106 356.9 14.0 2.1e-70 237.9 2.3 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF444) VWA_CoxE PF05762.14 ACT03316.1 - 0.012 15.0 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Nup54_57_C PF18570.1 ACT03317.1 - 0.4 10.3 3.1 0.79 9.4 3.1 1.5 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain Cys_rich_CPCC PF14206.6 ACT03319.1 - 1.4e-28 98.6 2.5 2e-28 98.0 2.5 1.3 1 0 0 1 1 1 1 Cysteine-rich CPCC DUF2157 PF09925.9 ACT03320.1 - 0.047 13.5 0.9 0.078 12.8 0.0 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) Imm17 PF15562.6 ACT03320.1 - 0.12 12.2 4.8 0.65 9.9 4.8 1.9 1 1 0 1 1 1 0 Immunity protein 17 Acetyltransf_10 PF13673.7 ACT03321.1 - 3.5e-13 49.6 0.1 4.5e-13 49.2 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT03321.1 - 2e-12 47.4 0.4 2.3e-12 47.2 0.4 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT03321.1 - 3.3e-11 43.4 1.4 4.4e-11 43.1 1.4 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT03321.1 - 4e-07 30.1 0.0 1.1e-06 28.7 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT03321.1 - 2.2e-05 24.3 0.4 0.00021 21.2 0.0 2.1 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.6 ACT03321.1 - 0.0026 17.8 0.1 0.012 15.8 0.0 1.9 1 1 1 2 2 2 1 GCN5-related N-acetyl-transferase PMT_2 PF13231.6 ACT03322.1 - 1.5e-10 41.6 13.5 1.5e-10 41.6 13.5 3.3 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Phage_holin_8 PF16931.5 ACT03322.1 - 0.11 12.5 3.4 0.066 13.2 1.0 1.9 2 0 0 2 2 2 0 Putative phage holin YlaC PF10777.9 ACT03322.1 - 5.4 6.9 8.5 0.94 9.3 0.2 2.8 2 0 0 2 2 2 0 Inner membrane protein YlaC FAD_binding_4 PF01565.23 ACT03323.1 - 2.5e-30 105.0 0.2 5e-30 104.1 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 ACT03323.1 - 6.3e-18 64.6 0.2 1.4e-17 63.5 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like Acetyltransf_3 PF13302.7 ACT03325.1 - 1.6e-21 77.5 0.1 1.8e-21 77.2 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT03325.1 - 3.1e-06 27.4 0.1 4e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 ACT03325.1 - 4.3e-06 26.9 0.0 5.3e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ACT03325.1 - 0.015 15.0 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CFAP91 PF14738.6 ACT03325.1 - 0.086 12.9 0.1 4.6 7.3 0.0 2.1 2 0 0 2 2 2 0 Cilia- and flagella-associated protein 91 MFS_1 PF07690.16 ACT03326.1 - 2.3e-35 122.2 47.0 3.8e-27 95.1 23.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 ACT03326.1 - 4.2e-08 32.1 6.9 4.2e-08 32.1 6.9 2.0 2 1 0 2 2 2 1 Transmembrane secretion effector Nuc_H_symport PF03825.16 ACT03326.1 - 2.4e-05 23.5 7.4 2.4e-05 23.5 7.4 2.7 1 1 1 2 2 2 1 Nucleoside H+ symporter Sugar_tr PF00083.24 ACT03326.1 - 0.18 10.6 28.6 0.011 14.6 14.5 2.4 2 0 0 2 2 2 0 Sugar (and other) transporter ATP-synt_ab PF00006.25 ACT03327.1 - 1.8e-08 34.3 0.0 0.0015 18.2 0.0 2.2 1 1 1 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain HTH_26 PF13443.6 ACT03327.1 - 0.00016 22.1 0.0 0.00039 20.8 0.0 1.7 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_3 PF01381.22 ACT03327.1 - 0.015 15.3 0.0 0.071 13.2 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix HisG_C PF08029.11 ACT03327.1 - 0.035 14.3 0.1 23 5.2 0.0 3.2 2 1 0 2 2 2 0 HisG, C-terminal domain LPAM_1 PF08139.12 ACT03327.1 - 1.3 9.7 3.5 3.4 8.3 3.5 1.7 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site PALP PF00291.25 ACT03328.1 - 2e-50 171.8 0.6 2.4e-50 171.6 0.6 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M20 PF01546.28 ACT03329.1 - 4e-38 131.2 0.0 7.9e-38 130.2 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ACT03329.1 - 5.6e-24 84.2 0.0 1.2e-23 83.1 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ACT03329.1 - 0.013 15.2 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Lipoprotein_9 PF03180.14 ACT03330.1 - 1.6e-76 256.5 1.6 1.9e-76 256.3 1.6 1.1 1 0 0 1 1 1 1 NLPA lipoprotein LPAM_2 PF13627.6 ACT03330.1 - 0.69 9.8 4.6 1.2 9.0 4.6 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Glutaminase PF04960.15 ACT03331.1 - 1.6e-116 388.5 0.0 1.8e-116 388.3 0.0 1.0 1 0 0 1 1 1 1 Glutaminase HNH_5 PF14279.6 ACT03332.1 - 9.6e-11 41.4 4.9 1.4e-10 40.8 4.9 1.3 1 0 0 1 1 1 1 HNH endonuclease HNH PF01844.23 ACT03332.1 - 1.9e-09 37.5 5.9 3.3e-09 36.8 5.9 1.4 1 0 0 1 1 1 1 HNH endonuclease HNH_4 PF13395.6 ACT03332.1 - 1e-05 25.3 0.0 2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 HNH endonuclease zf-RVT PF13966.6 ACT03332.1 - 0.068 13.9 0.7 0.088 13.5 0.0 1.6 1 1 1 2 2 2 0 zinc-binding in reverse transcriptase HD PF01966.22 ACT03333.1 - 6.6e-08 32.8 0.4 1.1e-07 32.1 0.4 1.3 1 0 0 1 1 1 1 HD domain tRNA_anti-codon PF01336.25 ACT03333.1 - 0.00048 20.1 0.0 0.00084 19.3 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain TraI_2 PF07514.11 ACT03333.1 - 0.0025 16.8 0.1 0.004 16.1 0.1 1.2 1 0 0 1 1 1 1 Putative helicase SLH PF00395.20 ACT03334.1 - 9.2e-19 67.2 1.8 1.7e-06 27.9 0.0 4.2 4 0 0 4 4 4 3 S-layer homology domain DUF4148 PF13663.6 ACT03334.1 - 0.016 15.4 0.8 3 8.1 1.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) NdhS PF11623.8 ACT03334.1 - 0.54 10.0 0.0 0.54 10.0 0.0 2.0 3 0 0 3 3 3 0 NAD(P)H dehydrogenase subunit S MFS_1_like PF12832.7 ACT03335.1 - 4.7e-46 157.4 34.9 7e-46 156.8 34.9 1.3 1 0 0 1 1 1 1 MFS_1 like family Nuc_H_symport PF03825.16 ACT03335.1 - 3.1e-17 62.7 28.3 4.1e-17 62.3 28.3 1.1 1 0 0 1 1 1 1 Nucleoside H+ symporter MFS_1 PF07690.16 ACT03335.1 - 3.7e-14 52.4 56.8 8.5e-08 31.5 32.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ACT03335.1 - 5.9e-06 25.1 32.5 5.9e-06 25.1 32.5 3.0 1 1 1 2 2 2 1 MFS/sugar transport protein GFO_IDH_MocA PF01408.22 ACT03336.1 - 3e-32 112.0 0.1 4.4e-32 111.4 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03336.1 - 4.8e-06 26.6 0.0 1.2e-05 25.3 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACT03336.1 - 0.0018 19.0 0.0 0.0028 18.3 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ACT03336.1 - 0.0045 17.5 0.1 0.0089 16.6 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 ACT03336.1 - 0.0087 15.4 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CoA_binding PF02629.19 ACT03336.1 - 0.024 15.3 0.1 0.051 14.3 0.1 1.6 1 0 0 1 1 1 0 CoA binding domain TrkA_N PF02254.18 ACT03336.1 - 0.029 14.6 0.1 0.05 13.9 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain DapB_N PF01113.20 ACT03336.1 - 0.033 14.3 0.0 0.057 13.6 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Gp_dh_N PF00044.24 ACT03336.1 - 0.037 14.4 0.1 0.072 13.4 0.1 1.5 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ACT03336.1 - 0.16 12.5 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ACT03336.1 - 0.17 12.1 0.5 0.47 10.7 0.5 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AP_endonuc_2 PF01261.24 ACT03337.1 - 1.7e-10 40.7 0.1 2.4e-10 40.2 0.1 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Ferritin_2 PF13668.6 ACT03337.1 - 0.13 12.4 0.0 0.26 11.5 0.0 1.6 1 1 0 1 1 1 0 Ferritin-like domain E1_dh PF00676.20 ACT03338.1 - 8.3e-69 231.8 0.2 1.2e-68 231.3 0.2 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 ACT03338.1 - 1.6e-57 194.1 0.1 4.6e-57 192.6 0.0 1.8 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 ACT03338.1 - 3.4e-38 130.7 0.3 7.5e-38 129.6 0.0 1.8 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 ACT03338.1 - 4.2e-06 26.2 0.5 4.2e-06 26.2 0.5 2.0 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus PFOR_II PF17147.4 ACT03338.1 - 0.04 14.2 0.0 0.084 13.2 0.0 1.5 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Ephrin_lbd PF01404.19 ACT03338.1 - 0.061 13.4 0.1 0.17 11.9 0.1 1.7 2 0 0 2 2 2 0 Ephrin receptor ligand binding domain 2-oxoacid_dh PF00198.23 ACT03339.1 - 3.9e-76 255.6 0.1 5.7e-76 255.0 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ACT03339.1 - 1e-24 86.2 6.1 2.3e-24 85.0 6.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 ACT03339.1 - 1.4e-09 37.6 6.3 6.6e-06 25.9 0.3 3.1 2 1 1 3 3 3 2 Biotin-lipoyl like E3_binding PF02817.17 ACT03339.1 - 6.6e-07 29.6 0.8 3.3e-06 27.3 0.1 2.4 2 0 0 2 2 2 1 e3 binding domain HlyD_3 PF13437.6 ACT03339.1 - 0.002 18.8 2.4 1.3 9.8 0.2 2.6 1 1 1 2 2 2 2 HlyD family secretion protein Peptidase_M23 PF01551.22 ACT03339.1 - 0.004 17.3 1.7 0.36 11.1 0.2 2.7 1 1 0 2 2 2 1 Peptidase family M23 HlyD_D23 PF16576.5 ACT03339.1 - 0.0055 16.0 1.1 1.4 8.0 0.1 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion PYNP_C PF07831.13 ACT03339.1 - 0.031 13.9 0.6 2 8.1 0.1 2.8 3 0 0 3 3 3 0 Pyrimidine nucleoside phosphorylase C-terminal domain RnfC_N PF13375.6 ACT03339.1 - 0.032 14.2 1.1 0.21 11.6 0.2 2.3 1 1 1 2 2 2 0 RnfC Barrel sandwich hybrid domain HTH_5 PF01022.20 ACT03340.1 - 2.5e-11 43.2 0.1 1.1e-10 41.2 0.1 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACT03340.1 - 7.5e-11 41.9 0.2 1.2e-10 41.3 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 ACT03340.1 - 1.5e-07 31.2 0.1 3.2e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 MarR family MarR PF01047.22 ACT03340.1 - 1.7e-07 31.1 0.0 4.8e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT03340.1 - 4.1e-07 29.5 0.0 6.8e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.10 ACT03340.1 - 9e-07 28.6 0.1 1.8e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_34 PF13601.6 ACT03340.1 - 0.00011 22.3 0.1 0.00017 21.7 0.1 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_11 PF08279.12 ACT03340.1 - 0.00042 20.2 0.1 0.00097 19.0 0.1 1.6 2 0 0 2 2 2 1 HTH domain HTH_Crp_2 PF13545.6 ACT03340.1 - 0.0026 17.7 0.0 0.006 16.5 0.0 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 ACT03340.1 - 0.0038 17.5 0.1 0.0073 16.6 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator TrmB PF01978.19 ACT03340.1 - 0.016 15.1 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF742 PF05331.11 ACT03340.1 - 0.02 14.7 0.1 0.031 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF742) Fe_dep_repress PF01325.19 ACT03340.1 - 0.022 14.9 1.2 0.031 14.5 0.1 1.8 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_CodY PF08222.11 ACT03340.1 - 0.051 13.1 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 CodY helix-turn-helix domain GntR PF00392.21 ACT03340.1 - 0.051 13.2 0.6 0.096 12.4 0.1 1.7 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family DprA_WH PF17782.1 ACT03340.1 - 0.065 13.3 0.4 0.11 12.7 0.4 1.3 1 0 0 1 1 1 0 DprA winged helix domain FaeA PF04703.12 ACT03340.1 - 0.07 13.5 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 FaeA-like protein HTH_AsnC-type PF13404.6 ACT03340.1 - 0.07 13.0 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_28 PF13518.6 ACT03340.1 - 0.11 12.6 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Dimerisation2 PF16864.5 ACT03340.1 - 0.16 11.9 0.1 0.26 11.3 0.1 1.3 1 0 0 1 1 1 0 Dimerisation domain Alpha-L-AF_C PF06964.12 ACT03341.1 - 3e-43 147.8 0.0 4.6e-43 147.3 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain GGDEF PF00990.21 ACT03342.1 - 6.4e-42 143.0 0.1 8.6e-42 142.6 0.1 1.2 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GAF_3 PF13492.6 ACT03342.1 - 0.008 16.5 0.0 0.015 15.6 0.0 1.6 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 ACT03342.1 - 0.02 15.2 0.0 0.12 12.7 0.0 2.0 1 1 1 2 2 2 0 GAF domain Guanylate_cyc PF00211.20 ACT03342.1 - 0.044 13.4 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain GGDEF_2 PF17853.1 ACT03342.1 - 0.082 13.2 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 GGDEF-like domain Tetrabrachion PF11401.8 ACT03342.1 - 0.13 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Tetrabrachion TauE PF01925.19 ACT03343.1 - 3e-32 112.1 32.1 3.8e-32 111.8 32.1 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Glyco_hydro_53 PF07745.13 ACT03344.1 - 2.4e-121 404.9 3.2 3.6e-121 404.3 3.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 SLH PF00395.20 ACT03344.1 - 9.1e-34 115.2 0.9 2e-11 43.7 0.1 4.0 3 0 0 3 3 3 3 S-layer homology domain Big_4 PF07532.11 ACT03344.1 - 2.5e-11 43.1 1.1 2.5e-11 43.1 1.1 2.3 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 4) CBM_4_9 PF02018.17 ACT03344.1 - 1.5e-06 28.5 11.1 0.00011 22.5 2.0 2.9 2 0 0 2 2 2 2 Carbohydrate binding domain Glyco_hydro_cc PF11790.8 ACT03344.1 - 0.0012 18.5 0.0 0.0024 17.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DUF2278 PF10042.9 ACT03344.1 - 0.031 14.3 0.0 0.48 10.4 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2278) CarboxypepD_reg PF13620.6 ACT03344.1 - 1.1 9.5 11.8 3.1 8.1 0.2 4.7 4 2 1 5 5 5 0 Carboxypeptidase regulatory-like domain DUF3502 PF12010.8 ACT03345.1 - 8e-28 97.7 4.0 5e-27 95.1 0.2 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3502) BPD_transp_1 PF00528.22 ACT03346.1 - 1.4e-07 31.5 28.1 5.4e-06 26.3 28.0 2.7 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component DUF4564 PF15169.6 ACT03346.1 - 0.3 10.8 2.5 0.79 9.4 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4564) TMCO5 PF14992.6 ACT03346.1 - 4 6.9 8.4 0.59 9.7 3.7 1.8 1 1 1 2 2 2 0 TMCO5 family BPD_transp_1 PF00528.22 ACT03347.1 - 3.8e-16 59.4 15.4 3.8e-16 59.4 15.4 2.2 1 1 0 2 2 2 2 Binding-protein-dependent transport system inner membrane component Response_reg PF00072.24 ACT03348.1 - 7.3e-26 90.5 0.0 1.5e-25 89.5 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT03348.1 - 6.8e-22 77.5 0.0 2e-21 76.1 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03348.1 - 6.4e-14 51.6 0.0 3.4e-07 30.2 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT03348.1 - 9e-13 48.5 0.7 2.3e-12 47.2 0.3 2.0 2 0 0 2 2 2 1 GGDEF-like domain dsDNA_bind PF01984.20 ACT03348.1 - 0.023 15.0 0.4 0.28 11.5 0.0 2.8 3 0 0 3 3 3 0 Double-stranded DNA-binding domain PAS_9 PF13426.7 ACT03348.1 - 0.11 12.7 0.0 0.62 10.4 0.0 2.3 1 0 0 1 1 1 0 PAS domain HTH_7 PF02796.15 ACT03348.1 - 0.15 12.2 0.0 6.2 7.0 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase His_kinase PF06580.13 ACT03349.1 - 1.4e-24 86.2 0.8 3.2e-24 85.0 0.1 2.0 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACT03349.1 - 4.5e-09 36.8 0.0 1.1e-08 35.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACT03349.1 - 6.5e-07 29.4 4.5 6.5e-07 29.4 4.5 1.8 2 0 0 2 2 2 1 Cache domain HAMP PF00672.25 ACT03349.1 - 1.2e-06 28.8 0.2 5.7e-06 26.6 0.1 2.2 2 0 0 2 2 2 1 HAMP domain Mrr_cat PF04471.12 ACT03351.1 - 1.3e-21 76.8 0.0 1.7e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Restriction endonuclease Mrr_cat_2 PF13156.6 ACT03351.1 - 2.4e-06 27.5 0.0 3.7e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease DUF4122 PF13498.6 ACT03351.1 - 0.13 11.9 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4122) Nucleoside_tran PF01733.18 ACT03351.1 - 0.2 11.0 0.0 0.26 10.6 0.0 1.1 1 0 0 1 1 1 0 Nucleoside transporter SpoVR PF04293.13 ACT03352.1 - 2.5e-164 546.9 0.4 3e-164 546.7 0.4 1.0 1 0 0 1 1 1 1 SpoVR like protein Methylase_S PF01420.19 ACT03353.1 - 1.6e-38 132.5 0.6 6e-22 78.6 0.0 2.4 2 1 0 2 2 2 2 Type I restriction modification DNA specificity domain DUF2508 PF10704.9 ACT03353.1 - 5.6 7.2 5.9 1.8 8.8 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) N6_Mtase PF02384.16 ACT03354.1 - 2.5e-76 256.9 0.0 3.5e-76 256.4 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase HsdM_N PF12161.8 ACT03354.1 - 1.1e-11 45.6 2.0 6.5e-10 39.8 0.8 3.2 2 1 0 2 2 2 1 HsdM N-terminal domain UPF0020 PF01170.18 ACT03354.1 - 2.1e-06 27.6 0.0 3.9e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Eco57I PF07669.11 ACT03354.1 - 0.00022 21.7 0.0 0.00068 20.1 0.0 1.8 1 0 0 1 1 1 1 Eco57I restriction-modification methylase MTS PF05175.14 ACT03354.1 - 0.0045 16.5 0.0 0.0078 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain DegQ PF08181.11 ACT03354.1 - 0.048 13.8 0.4 0.23 11.6 0.4 2.3 1 0 0 1 1 1 0 DegQ (SacQ) family EcoEI_R_C PF08463.10 ACT03355.1 - 4.3e-35 121.3 0.7 4.3e-35 121.3 0.7 2.5 3 0 0 3 3 3 1 EcoEI R protein C-terminal ResIII PF04851.15 ACT03355.1 - 1.1e-34 119.9 0.7 3e-34 118.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 ACT03355.1 - 1e-14 54.7 0.1 1e-14 54.7 0.1 2.0 2 0 0 2 2 2 1 SWI2/SNF2 ATPase Helicase_C PF00271.31 ACT03355.1 - 2e-11 44.2 0.1 5.4e-11 42.8 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ACT03355.1 - 1.4e-07 31.5 0.0 1.9e-06 27.8 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase HSDR_N PF04313.14 ACT03355.1 - 1.7e-07 31.4 0.1 0.011 15.7 0.1 3.0 1 1 1 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) DUF4145 PF13643.6 ACT03355.1 - 2.6e-07 30.6 0.0 2.6e-07 30.6 0.0 2.8 4 0 0 4 4 4 1 Domain of unknown function (DUF4145) DUF2075 PF09848.9 ACT03355.1 - 0.0013 18.1 0.0 0.0042 16.4 0.0 1.9 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 ACT03355.1 - 0.093 12.5 0.0 0.27 10.9 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein tRNA_anti-codon PF01336.25 ACT03355.1 - 0.11 12.5 0.0 0.37 10.8 0.0 1.9 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Strep_SA_rep PF06696.11 ACT03355.1 - 0.28 11.2 4.8 0.88 9.6 4.8 1.8 1 0 0 1 1 1 0 Streptococcal surface antigen repeat DUF2968 PF11180.8 ACT03355.1 - 0.6 9.7 12.2 0.66 9.6 6.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) Peptidase_S49_N PF08496.10 ACT03355.1 - 6.8 6.7 7.1 2.6 8.1 3.7 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DEAD PF00270.29 ACT03356.1 - 3.3e-15 56.3 0.1 2.2e-14 53.6 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ACT03356.1 - 2.6e-14 53.5 0.0 4.1e-10 40.0 0.0 3.0 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 ACT03356.1 - 0.00046 20.2 0.0 0.0018 18.3 0.0 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF559 PF04480.12 ACT03356.1 - 0.00077 19.3 1.9 0.0026 17.6 0.1 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF559) Baculo_PEP_C PF04513.12 ACT03357.1 - 0.0081 16.2 11.3 0.021 14.8 11.2 1.7 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Interferon PF00143.19 ACT03357.1 - 0.0092 16.2 6.7 0.011 15.9 6.7 1.2 1 0 0 1 1 1 1 Interferon alpha/beta domain MCPsignal PF00015.21 ACT03357.1 - 0.013 15.3 4.9 0.019 14.8 4.9 1.3 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Sec34 PF04136.15 ACT03357.1 - 0.016 15.1 4.8 0.016 15.1 4.8 2.0 1 1 1 2 2 2 0 Sec34-like family Jnk-SapK_ap_N PF09744.9 ACT03357.1 - 0.041 14.1 10.9 0.06 13.6 10.9 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Muted PF14942.6 ACT03357.1 - 0.044 14.1 10.9 0.053 13.9 10.9 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein YscO-like PF16789.5 ACT03357.1 - 0.088 12.8 8.0 0.17 11.9 8.0 1.6 1 1 0 1 1 1 0 YscO-like protein DUF1398 PF07166.11 ACT03357.1 - 0.12 12.5 1.8 0.14 12.2 1.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1398) Syntaxin_2 PF14523.6 ACT03357.1 - 0.12 12.8 15.1 0.077 13.4 1.5 2.1 1 1 1 2 2 2 0 Syntaxin-like protein Exonuc_VII_L PF02601.15 ACT03357.1 - 0.13 11.8 6.6 0.15 11.6 6.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit KH_5 PF13184.6 ACT03357.1 - 0.13 12.3 0.2 3.4 7.8 0.0 2.2 2 0 0 2 2 2 0 NusA-like KH domain Guanylate_cyc PF00211.20 ACT03357.1 - 0.17 11.5 2.2 0.37 10.4 2.2 1.5 1 1 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain COG2 PF06148.11 ACT03357.1 - 0.18 11.9 9.2 0.32 11.1 2.4 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF745 PF05335.13 ACT03357.1 - 0.2 11.4 8.9 0.27 11.0 8.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) CorA PF01544.18 ACT03357.1 - 0.22 10.8 6.5 0.32 10.2 6.5 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF1664 PF07889.12 ACT03357.1 - 0.31 11.1 12.6 1.6 8.8 2.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 ACT03357.1 - 0.37 9.4 10.7 0.46 9.1 10.7 1.0 1 0 0 1 1 1 0 AAA domain IFT57 PF10498.9 ACT03357.1 - 0.69 8.8 12.6 0.29 10.0 9.4 1.6 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 THOC7 PF05615.13 ACT03357.1 - 0.78 10.0 9.9 3.7 7.8 9.9 2.0 1 1 0 1 1 1 0 Tho complex subunit 7 RecG_N PF17190.4 ACT03357.1 - 1.2 10.0 7.3 1.8 9.4 1.2 2.4 1 1 1 2 2 2 0 RecG N-terminal helical domain DUF4200 PF13863.6 ACT03357.1 - 1.5 9.2 13.1 1.7 9.1 6.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) ABC_tran_Xtn PF12848.7 ACT03357.1 - 2 8.5 6.5 0.49 10.5 0.5 2.5 1 1 2 3 3 3 0 ABC transporter Med9 PF07544.13 ACT03357.1 - 3.1 8.0 10.2 3.4 7.8 1.3 2.6 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 FOXP-CC PF16159.5 ACT03357.1 - 4.5 8.0 6.5 14 6.4 0.3 2.2 2 0 0 2 2 2 0 FOXP coiled-coil domain FlaC_arch PF05377.11 ACT03357.1 - 7.2 7.1 15.4 3.9 8.0 4.7 3.7 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) SIR2 PF02146.17 ACT03359.1 - 7.1e-45 153.1 0.0 8.9e-45 152.8 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 ACT03359.1 - 0.00045 20.0 0.0 0.0012 18.6 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain WYL PF13280.6 ACT03362.1 - 4.4e-36 124.5 0.0 7.6e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 WYL domain GntR PF00392.21 ACT03362.1 - 0.0088 15.7 0.0 0.026 14.2 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 ACT03362.1 - 0.02 14.8 0.0 0.053 13.5 0.0 1.7 1 0 0 1 1 1 0 HTH domain Dpoe2NT PF12213.8 ACT03362.1 - 0.029 14.7 0.4 0.6 10.4 0.0 2.7 2 1 1 3 3 3 0 DNA polymerases epsilon N terminal EAP30 PF04157.16 ACT03362.1 - 0.032 13.5 0.0 0.16 11.2 0.0 1.9 1 1 0 1 1 1 0 EAP30/Vps36 family Phg_2220_C PF09524.10 ACT03362.1 - 0.034 14.2 1.7 0.11 12.6 0.1 2.7 3 0 0 3 3 3 0 Conserved phage C-terminus (Phg_2220_C) HTH_36 PF13730.6 ACT03362.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Sec8_exocyst PF04048.14 ACT03363.1 - 0.0027 17.6 8.7 0.0027 17.6 8.7 2.4 2 1 0 2 2 2 1 Sec8 exocyst complex component specific domain Rsa3 PF14615.6 ACT03363.1 - 0.016 14.8 4.8 0.67 9.6 0.3 3.6 3 0 0 3 3 3 0 Ribosome-assembly protein 3 AT_hook PF02178.19 ACT03363.1 - 0.023 14.6 2.3 0.042 13.7 2.3 1.5 1 0 0 1 1 1 0 AT hook motif UPF0242 PF06785.11 ACT03363.1 - 0.24 11.5 40.8 0.04 14.0 14.5 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Leu_zip PF15294.6 ACT03363.1 - 2 7.9 28.0 1.9 7.9 19.3 2.6 1 1 1 2 2 2 0 Leucine zipper Fez1 PF06818.15 ACT03363.1 - 3.6 8.0 31.8 1.1 9.7 14.8 2.3 1 1 1 2 2 2 0 Fez1 DUF641 PF04859.12 ACT03363.1 - 8.1 6.8 20.1 0.85 10.0 9.2 3.1 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Resolvase PF00239.21 ACT03365.1 - 5.1e-43 146.7 3.5 1.2e-42 145.4 0.3 2.3 2 0 0 2 2 2 1 Resolvase, N terminal domain Recombinase PF07508.13 ACT03365.1 - 7.4e-28 97.0 2.1 7.7e-28 96.9 0.3 1.9 2 0 0 2 2 2 1 Recombinase Zn_ribbon_recom PF13408.6 ACT03365.1 - 3.3e-14 53.1 2.1 6.8e-14 52.1 2.1 1.6 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain DUF1018 PF06252.12 ACT03365.1 - 0.017 16.1 0.8 0.46 11.5 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1018) DUF4795 PF16043.5 ACT03365.1 - 0.26 10.9 4.1 0.55 9.8 4.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) HTH_3 PF01381.22 ACT03366.1 - 4.4e-11 42.7 0.2 7e-11 42.0 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 ACT03366.1 - 1.6e-10 40.8 0.0 2.3e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ACT03366.1 - 1.5e-09 38.0 0.0 2.6e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 ACT03366.1 - 6.2e-06 26.0 0.0 9.3e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 ACT03366.1 - 1e-05 25.9 0.1 5.4e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 Cro/C1-type HTH DNA-binding domain HTH_37 PF13744.6 ACT03366.1 - 0.00037 20.4 0.5 0.0014 18.6 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain TamB PF04357.13 ACT03366.1 - 0.04 13.2 0.1 0.044 13.0 0.1 1.0 1 0 0 1 1 1 0 TamB, inner membrane protein subunit of TAM complex MarR PF01047.22 ACT03366.1 - 0.057 13.4 0.1 0.46 10.4 0.0 2.3 3 0 0 3 3 3 0 MarR family Resolvase PF00239.21 ACT03368.1 - 1.6e-27 96.4 0.7 3.4e-27 95.4 0.7 1.6 1 0 0 1 1 1 1 Resolvase, N terminal domain Recombinase PF07508.13 ACT03368.1 - 3.3e-09 37.1 0.8 1.5e-08 35.0 0.2 2.2 2 0 0 2 2 2 1 Recombinase Zn_ribbon_recom PF13408.6 ACT03368.1 - 1.8e-05 25.1 0.1 1.8e-05 25.1 0.1 1.9 2 0 0 2 2 2 1 Recombinase zinc beta ribbon domain Resolvase PF00239.21 ACT03369.1 - 5.1e-20 72.1 0.1 1.2e-19 70.8 0.1 1.7 1 0 0 1 1 1 1 Resolvase, N terminal domain Recombinase PF07508.13 ACT03369.1 - 8.2e-13 48.7 0.6 2e-12 47.4 0.6 1.7 1 0 0 1 1 1 1 Recombinase Snapin_Pallidin PF14712.6 ACT03369.1 - 0.0019 18.6 7.8 0.044 14.2 0.4 2.5 2 0 0 2 2 2 2 Snapin/Pallidin Zn_ribbon_recom PF13408.6 ACT03369.1 - 0.065 13.8 4.5 0.18 12.3 4.5 1.8 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain DUF4200 PF13863.6 ACT03369.1 - 0.27 11.7 2.4 0.8 10.1 2.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Resolvase PF00239.21 ACT03370.1 - 0.0017 18.5 0.0 0.002 18.2 0.0 1.1 1 0 0 1 1 1 1 Resolvase, N terminal domain CNH PF00780.22 ACT03370.1 - 0.044 13.4 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 CNH domain PcfK PF14058.6 ACT03370.1 - 0.13 12.5 0.1 0.2 12.0 0.1 1.3 1 0 0 1 1 1 0 PcfK-like protein AAA_21 PF13304.6 ACT03371.1 - 1.7e-07 31.4 4.3 4.5e-05 23.4 0.7 3.1 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT03371.1 - 2.3e-07 30.5 4.9 4.1e-06 26.4 2.4 2.9 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain DUF4407 PF14362.6 ACT03371.1 - 0.0015 18.0 6.8 0.0045 16.4 2.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4407) Macro_2 PF14519.6 ACT03371.1 - 0.036 13.4 0.9 0.16 11.3 0.1 2.2 2 0 0 2 2 2 0 Macro-like domain Cypo_polyhedrin PF05865.11 ACT03371.1 - 0.044 13.2 0.7 1.3 8.3 0.2 2.5 2 0 0 2 2 2 0 Cypovirus polyhedrin protein AAA_16 PF13191.6 ACT03371.1 - 0.064 13.6 0.1 0.29 11.5 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ACT03371.1 - 0.13 12.0 0.0 0.41 10.4 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Reprolysin_5 PF13688.6 ACT03371.1 - 0.16 12.1 0.1 0.75 9.9 0.1 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12 DUF1664 PF07889.12 ACT03371.1 - 0.32 11.0 8.7 0.44 10.6 2.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) ABC_tran PF00005.27 ACT03371.1 - 1.9 9.0 8.0 3.4 8.2 1.9 3.9 2 2 0 2 2 2 0 ABC transporter Mrr_cat PF04471.12 ACT03372.1 - 4e-20 72.0 0.0 8.5e-20 70.9 0.0 1.5 2 0 0 2 2 2 1 Restriction endonuclease Mrr_cat_2 PF13156.6 ACT03372.1 - 2.1e-06 27.7 0.0 8.2e-06 25.7 0.0 1.8 2 0 0 2 2 2 1 Restriction endonuclease NVEALA PF14055.6 ACT03372.1 - 0.0011 18.9 1.0 0.0037 17.2 0.0 2.1 2 0 0 2 2 2 1 NVEALA protein ATPgrasp_YheCD PF14398.6 ACT03373.1 - 2e-56 191.1 2.4 2.5e-56 190.8 2.4 1.0 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACT03373.1 - 8.3e-09 35.1 0.2 2.5e-07 30.3 0.2 2.1 1 1 0 1 1 1 1 Sugar-transfer associated ATP-grasp GSH-S_ATP PF02955.16 ACT03373.1 - 5.9e-05 22.5 0.2 0.00088 18.7 0.1 2.3 1 1 1 2 2 2 1 Prokaryotic glutathione synthetase, ATP-grasp domain HHH_3 PF12836.7 ACT03373.1 - 0.0092 16.2 1.1 1.2 9.5 0.1 2.8 3 0 0 3 3 3 1 Helix-hairpin-helix motif TTL PF03133.15 ACT03373.1 - 0.018 14.2 0.1 1.5 7.9 0.0 2.1 2 0 0 2 2 2 0 Tubulin-tyrosine ligase family GshA PF08886.11 ACT03373.1 - 0.11 11.0 0.3 0.14 10.7 0.3 1.2 1 0 0 1 1 1 0 Glutamate-cysteine ligase NLPC_P60 PF00877.19 ACT03375.1 - 6.4e-08 32.6 0.1 1.4e-07 31.5 0.1 1.6 1 0 0 1 1 1 1 NlpC/P60 family SH3_3 PF08239.11 ACT03375.1 - 1.9e-05 24.8 1.1 5.7e-05 23.3 1.1 1.9 1 0 0 1 1 1 1 Bacterial SH3 domain DUF1287 PF06940.11 ACT03375.1 - 0.086 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1287) Transglut_core PF01841.19 ACT03377.1 - 7e-23 81.2 0.0 1.3e-22 80.4 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Bact_transglu_N PF08379.10 ACT03377.1 - 2.1e-21 76.6 0.5 5.1e-21 75.4 0.5 1.7 1 0 0 1 1 1 1 Bacterial transglutaminase-like N-terminal region DUF553 PF04473.12 ACT03377.1 - 0.012 15.2 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase-like domain Transglut_core3 PF13471.6 ACT03377.1 - 0.23 11.3 1.3 0.5 10.3 0.1 2.1 3 0 0 3 3 3 0 Transglutaminase-like superfamily Alpha-E PF04168.12 ACT03378.1 - 6.3e-82 275.7 0.5 7e-82 275.5 0.5 1.0 1 0 0 1 1 1 1 A predicted alpha-helical domain with a conserved ER motif. DUF386 PF04074.12 ACT03378.1 - 0.038 13.9 0.1 0.073 13.0 0.1 1.5 1 0 0 1 1 1 0 YhcH/YjgK/YiaL CP_ATPgrasp_2 PF14403.6 ACT03379.1 - 1.8e-157 524.1 0.0 2.3e-157 523.7 0.0 1.1 1 0 0 1 1 1 1 Circularly permuted ATP-grasp type 2 CP_ATPgrasp_1 PF04174.13 ACT03379.1 - 1.6e-141 471.1 0.5 2.4e-141 470.6 0.0 1.5 2 0 0 2 2 2 1 A circularly permuted ATPgrasp Protoglobin PF11563.8 ACT03380.1 - 5.5e-38 130.4 0.5 1.1e-37 129.4 0.5 1.5 1 0 0 1 1 1 1 Protoglobin MCPsignal PF00015.21 ACT03380.1 - 1.1e-23 83.9 15.5 1.3e-23 83.7 5.7 2.5 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain PspA_IM30 PF04012.12 ACT03380.1 - 0.018 14.7 1.6 0.018 14.7 1.6 2.3 2 0 0 2 2 2 0 PspA/IM30 family Bac_globin PF01152.21 ACT03380.1 - 0.085 13.0 1.3 0.42 10.8 0.0 2.6 3 0 0 3 3 3 0 Bacterial-like globin Syntaxin-6_N PF09177.11 ACT03380.1 - 0.21 12.2 6.5 0.51 10.9 1.6 2.8 1 1 0 2 2 2 0 Syntaxin 6, N-terminal GCN5L1 PF06320.13 ACT03380.1 - 1.6 8.9 10.6 1.4 9.1 0.2 2.9 3 0 0 3 3 3 0 GCN5-like protein 1 (GCN5L1) AIP3 PF03915.13 ACT03380.1 - 2.9 6.9 10.1 4.8 6.2 2.1 2.3 1 1 0 2 2 2 0 Actin interacting protein 3 DUF948 PF06103.11 ACT03380.1 - 3.1 8.1 8.4 6.5 7.1 1.8 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) AAA_PrkA PF08298.11 ACT03381.1 - 6.2e-140 466.2 0.1 1.1e-139 465.4 0.1 1.4 1 0 0 1 1 1 1 PrkA AAA domain PrkA PF06798.12 ACT03381.1 - 1.1e-96 323.4 8.6 2.1e-96 322.5 8.6 1.5 1 0 0 1 1 1 1 PrkA serine protein kinase C-terminal domain Rad17 PF03215.15 ACT03381.1 - 0.0045 16.9 0.1 0.026 14.5 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 ACT03381.1 - 0.033 14.6 0.0 0.094 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.26 ACT03381.1 - 0.055 13.2 0.0 0.34 10.6 0.0 2.2 3 0 0 3 3 3 0 Sigma-54 interaction domain YppF PF14178.6 ACT03381.1 - 0.089 12.7 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 YppF-like protein AAA_29 PF13555.6 ACT03381.1 - 0.21 11.4 0.0 0.44 10.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AMP-binding_C_2 PF14535.6 ACT03381.1 - 0.46 10.8 2.3 1.6 9.1 1.1 2.6 2 1 0 2 2 2 0 AMP-binding enzyme C-terminal domain DUF2161 PF09929.9 ACT03382.1 - 9.4e-38 128.9 0.1 1.7e-37 128.1 0.1 1.4 1 0 0 1 1 1 1 Putative PD-(D/E)XK phosphodiesterase (DUF2161) Aminotran_1_2 PF00155.21 ACT03383.1 - 2e-36 125.9 0.0 2.6e-36 125.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ACT03383.1 - 2.3e-12 46.5 0.0 3.3e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.17 ACT03383.1 - 1.6e-07 31.0 0.0 3.4e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 ACT03383.1 - 7.1e-06 25.5 0.0 1.7e-05 24.2 0.0 1.6 2 0 0 2 2 2 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 ACT03383.1 - 0.0016 17.1 0.0 0.005 15.4 0.0 1.7 1 1 1 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme AMP-binding PF00501.28 ACT03383.1 - 0.086 11.4 0.0 0.19 10.3 0.0 1.6 1 1 1 2 2 2 0 AMP-binding enzyme Baculo_11_kDa PF06143.11 ACT03384.1 - 0.044 13.4 0.3 0.044 13.4 0.3 1.0 1 0 0 1 1 1 0 Baculovirus 11 kDa family Conotoxin PF02950.17 ACT03384.1 - 0.11 13.5 0.1 0.11 13.5 0.1 1.0 1 0 0 1 1 1 0 Conotoxin MazE_antitoxin PF04014.18 ACT03385.1 - 6.5e-10 38.7 0.0 8.3e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin MraZ PF02381.18 ACT03385.1 - 0.014 15.3 0.0 0.02 14.9 0.0 1.2 1 0 0 1 1 1 0 MraZ protein, putative antitoxin-like SpoU_methylase PF00588.19 ACT03386.1 - 2.4e-35 121.8 0.0 2.7e-35 121.6 0.0 1.0 1 0 0 1 1 1 1 SpoU rRNA Methylase family TSGP1 PF07771.11 ACT03386.1 - 0.11 12.6 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Tick salivary peptide group 1 Response_reg PF00072.24 ACT03387.1 - 2.5e-31 108.1 0.1 3.7e-31 107.6 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT03387.1 - 5.7e-29 100.0 0.1 1.1e-28 99.1 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal B12-binding PF02310.19 ACT03387.1 - 0.15 12.1 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 B12 binding domain Aminotran_5 PF00266.19 ACT03388.1 - 1.5e-47 162.3 0.0 1.7e-47 162.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V LigT_PEase PF02834.16 ACT03389.1 - 8e-22 77.2 0.0 1.5e-11 44.3 0.0 2.1 2 0 0 2 2 2 2 LigT like Phosphoesterase 2_5_RNA_ligase2 PF13563.6 ACT03389.1 - 2e-11 44.0 0.0 2.4e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily AKAP7_NLS PF10469.9 ACT03389.1 - 4.9e-05 23.3 0.0 9e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain TetR_C_29 PF17938.1 ACT03389.1 - 0.058 13.5 0.0 0.091 12.9 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Gln-synt_C PF00120.24 ACT03390.1 - 8e-131 436.1 0.0 9.3e-131 435.9 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 ACT03390.1 - 4e-29 100.2 0.3 7.9e-29 99.2 0.3 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain DAHP_synth_1 PF00793.20 ACT03391.1 - 4.7e-65 219.2 0.0 6.6e-65 218.7 0.0 1.2 1 0 0 1 1 1 1 DAHP synthetase I family DAHP_snth_FXD PF18152.1 ACT03391.1 - 2e-20 72.3 3.9 2e-20 72.3 3.9 2.0 2 0 0 2 2 2 1 DAHP synthase ferredoxin-like domain NeuB PF03102.14 ACT03391.1 - 1.2e-07 31.5 0.0 2.3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 NeuB family Sigma70_r1_1 PF03979.14 ACT03391.1 - 0.19 11.8 0.0 42 4.3 0.0 3.0 3 0 0 3 3 3 0 Sigma-70 factor, region 1.1 LYTB PF02401.18 ACT03392.1 - 3e-80 269.3 0.4 3.4e-80 269.1 0.4 1.0 1 0 0 1 1 1 1 LytB protein CoA_binding_2 PF13380.6 ACT03392.1 - 0.021 15.3 0.5 0.17 12.4 0.0 2.6 2 2 1 3 3 3 0 CoA binding domain HATPase_c PF02518.26 ACT03393.1 - 2.5e-22 79.5 0.0 5.4e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT03393.1 - 3.2e-18 65.5 2.0 6.6e-18 64.5 0.6 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT03393.1 - 2.5e-11 43.8 0.0 8.5e-11 42.1 0.0 2.0 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 ACT03393.1 - 0.0096 15.8 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TssO PF17561.2 ACT03393.1 - 0.42 10.7 2.8 0.39 10.8 0.2 2.3 2 1 1 3 3 3 0 Type VI secretion system, TssO Response_reg PF00072.24 ACT03394.1 - 2.7e-32 111.2 0.1 3.8e-31 107.6 0.1 2.1 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT03394.1 - 1.7e-27 95.3 0.5 6.2e-27 93.5 0.1 2.0 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal Trypsin_2 PF13365.6 ACT03395.1 - 7.6e-32 111.3 0.2 7.6e-32 111.3 0.2 2.3 2 0 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.26 ACT03395.1 - 3.6e-15 56.4 0.0 8.8e-15 55.1 0.0 1.6 1 1 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 ACT03395.1 - 1.6e-12 47.6 0.2 4.6e-12 46.1 0.2 1.8 1 0 0 1 1 1 1 PDZ domain Peptidase_S46 PF10459.9 ACT03395.1 - 0.00026 19.8 0.1 0.029 13.0 0.1 2.3 2 0 0 2 2 2 2 Peptidase S46 PDZ PF00595.24 ACT03395.1 - 0.00038 20.7 0.2 0.0064 16.8 0.2 2.6 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 ACT03395.1 - 0.00097 18.9 0.9 0.0031 17.3 0.0 2.4 3 0 0 3 3 3 1 PDZ domain Peptidase_S32 PF05579.13 ACT03395.1 - 0.0036 16.5 0.1 0.94 8.6 0.0 2.4 2 0 0 2 2 2 2 Equine arteritis virus serine endopeptidase S32 PsbX PF06596.11 ACT03395.1 - 0.024 14.6 0.4 0.048 13.7 0.4 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) Peptidase_S29 PF02907.15 ACT03395.1 - 0.069 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Smg4_UPF3 PF03467.15 ACT03395.1 - 0.22 11.5 1.9 1.5 8.8 0.0 2.2 2 0 0 2 2 2 0 Smg-4/UPF3 family Mpp10 PF04006.12 ACT03395.1 - 8.9 4.6 8.1 0.89 7.9 2.8 1.8 2 0 0 2 2 2 0 Mpp10 protein YugN PF08868.10 ACT03396.1 - 9.7e-48 161.4 0.2 1.1e-47 161.2 0.2 1.0 1 0 0 1 1 1 1 YugN-like family Response_reg PF00072.24 ACT03397.1 - 4.4e-27 94.5 0.1 7.4e-27 93.7 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 ACT03397.1 - 6.6e-20 70.4 1.0 1.1e-19 69.7 1.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACT03397.1 - 5e-11 42.1 0.2 1.2e-10 40.9 0.2 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT03397.1 - 1.1e-06 28.1 1.2 2e-06 27.2 0.4 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_23 PF13384.6 ACT03397.1 - 0.00017 21.3 0.1 0.00047 19.9 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_24 PF13412.6 ACT03397.1 - 0.00032 20.2 0.1 0.00067 19.2 0.1 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 ACT03397.1 - 0.0054 16.8 0.0 0.016 15.3 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.12 ACT03397.1 - 0.029 14.3 0.1 0.072 13.1 0.1 1.7 1 0 0 1 1 1 0 HTH domain HTH_38 PF13936.6 ACT03397.1 - 0.031 14.1 0.3 0.13 12.0 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain Herpes_BLRF2 PF05812.12 ACT03397.1 - 0.086 13.0 0.4 0.14 12.3 0.4 1.3 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein DUF742 PF05331.11 ACT03397.1 - 0.12 12.2 0.6 0.29 10.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF742) HTH_Tnp_ISL3 PF13542.6 ACT03397.1 - 0.12 11.8 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HisKA_3 PF07730.13 ACT03398.1 - 3.6e-15 56.2 3.6 1e-14 54.7 3.6 1.9 1 0 0 1 1 1 1 Histidine kinase HATPase_c PF02518.26 ACT03398.1 - 1.7e-07 31.8 0.1 9.8e-07 29.3 0.1 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT03398.1 - 4.5e-05 23.4 0.0 0.00016 21.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain HAMP PF00672.25 ACT03398.1 - 0.0018 18.6 0.0 0.0046 17.3 0.0 1.8 1 0 0 1 1 1 1 HAMP domain DUF2154 PF09922.9 ACT03399.1 - 4.9e-37 126.3 1.3 4.9e-37 126.3 1.3 1.5 2 0 0 2 2 2 1 Cell wall-active antibiotics response 4TMS YvqF Lambda_Kil PF06301.11 ACT03399.1 - 0.0052 16.4 0.3 4.8 6.9 0.0 3.7 4 0 0 4 4 4 2 Bacteriophage lambda Kil protein UPF0242 PF06785.11 ACT03399.1 - 0.025 14.7 0.6 0.057 13.5 0.6 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Phage_Coat_Gp8 PF05371.12 ACT03399.1 - 0.071 12.9 0.6 0.91 9.3 0.0 2.2 2 0 0 2 2 2 0 Phage major coat protein, Gp8 DUF3584 PF12128.8 ACT03399.1 - 0.37 8.2 6.6 0.5 7.8 6.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Ammonium_transp PF00909.21 ACT03400.1 - 3e-113 378.5 36.7 3.4e-113 378.4 36.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family RNA_polI_A14 PF08203.11 ACT03401.1 - 0.026 15.2 0.1 0.042 14.6 0.1 1.3 1 0 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 P4Ha_N PF08336.11 ACT03401.1 - 0.2 11.6 2.6 1.3 9.0 1.4 2.0 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 3D PF06725.11 ACT03403.1 - 5.3e-19 68.2 0.2 8.7e-19 67.5 0.2 1.4 1 0 0 1 1 1 1 3D domain tRNA-synt_2b PF00587.25 ACT03404.1 - 2.5e-34 118.8 0.3 9.7e-34 116.9 0.2 2.0 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ACT03404.1 - 9e-23 80.2 0.4 2.4e-22 78.9 0.4 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 ACT03404.1 - 1.5e-17 63.4 0.0 6e-17 61.5 0.0 2.0 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 ACT03404.1 - 1.1e-12 47.7 0.0 3.3e-12 46.3 0.0 1.9 1 0 0 1 1 1 1 TGS domain tRNA-synt_His PF13393.6 ACT03404.1 - 0.0041 16.4 0.0 0.0071 15.6 0.0 1.4 1 0 0 1 1 1 1 Histidyl-tRNA synthetase YtxC PF08812.11 ACT03405.1 - 1.5e-61 207.8 1.4 1.9e-61 207.4 1.4 1.2 1 0 0 1 1 1 1 YtxC-like family DDE_Tnp_IS1595 PF12762.7 ACT03405.1 - 0.15 12.1 0.0 0.42 10.6 0.0 1.7 1 1 0 1 1 1 0 ISXO2-like transposase domain Methyltransf_21 PF05050.12 ACT03407.1 - 5.3e-15 55.9 0.0 7.3e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Radical_SAM PF04055.21 ACT03408.1 - 3.8e-18 66.4 0.0 8.2e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 ACT03408.1 - 0.066 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain Cys_Met_Meta_PP PF01053.20 ACT03409.1 - 9.8e-148 491.7 0.0 1.1e-147 491.6 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ACT03409.1 - 1.8e-06 27.5 0.2 8.4e-06 25.3 0.2 2.0 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ACT03409.1 - 3.3e-06 26.3 0.0 6.2e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 ACT03409.1 - 1e-05 24.9 0.0 1.2e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ACT03409.1 - 0.008 15.5 0.1 0.048 12.9 0.1 2.0 1 1 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 ACT03409.1 - 0.01 14.7 0.0 0.015 14.1 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein Cys_Met_Meta_PP PF01053.20 ACT03410.1 - 3.2e-145 483.5 0.0 3.6e-145 483.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ACT03410.1 - 1.8e-05 24.1 0.0 2.8e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ACT03410.1 - 4.1e-05 22.7 0.0 7.1e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V GDC-P PF02347.16 ACT03410.1 - 0.011 14.6 0.0 0.016 14.1 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein SelA PF03841.13 ACT03410.1 - 0.029 13.4 0.0 0.19 10.7 0.0 1.9 2 0 0 2 2 2 0 L-seryl-tRNA selenium transferase Met_gamma_lyase PF06838.11 ACT03410.1 - 0.13 10.7 0.0 0.19 10.2 0.0 1.4 1 1 0 1 1 1 0 Methionine gamma-lyase HTS PF04204.16 ACT03411.1 - 4.9e-143 475.5 0.1 5.5e-143 475.3 0.1 1.0 1 0 0 1 1 1 1 Homoserine O-succinyltransferase DUF903 PF06004.12 ACT03411.1 - 0.03 14.2 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) CorA PF01544.18 ACT03412.1 - 3.2e-63 213.8 4.2 4.2e-63 213.4 4.2 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 ACT03412.1 - 0.032 13.0 0.4 0.048 12.4 0.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Gram_pos_anchor PF00746.21 ACT03412.1 - 0.89 9.6 2.9 1.5 8.8 2.9 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif PALP PF00291.25 ACT03413.1 - 1.9e-69 234.3 0.3 2.1e-69 234.2 0.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SDH_alpha PF03313.15 ACT03413.1 - 0.018 14.7 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Serine dehydratase alpha chain Pribosyltran PF00156.27 ACT03413.1 - 0.071 12.6 0.0 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 Phosphoribosyl transferase domain ADH_zinc_N PF00107.26 ACT03413.1 - 0.12 12.3 0.1 0.57 10.2 0.0 2.2 2 1 0 2 2 2 0 Zinc-binding dehydrogenase ATG22 PF11700.8 ACT03414.1 - 5.7e-68 229.7 35.5 2.1e-55 188.2 17.1 3.0 1 1 2 3 3 3 3 Vacuole effluxer Atg22 like MFS_1 PF07690.16 ACT03414.1 - 9.1e-24 84.0 74.2 6.1e-18 64.9 42.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ACT03414.1 - 0.00062 18.4 36.3 0.037 12.6 36.0 3.6 1 1 0 1 1 1 1 MFS/sugar transport protein LysR_substrate PF03466.20 ACT03415.1 - 7.4e-45 152.9 0.0 9.8e-45 152.5 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT03415.1 - 1.1e-16 60.5 0.1 2e-16 59.7 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like_2 PF12849.7 ACT03415.1 - 0.036 13.8 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 PBP superfamily domain PNK3P PF08645.11 ACT03415.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Polynucleotide kinase 3 phosphatase HTH_24 PF13412.6 ACT03415.1 - 0.14 11.8 0.1 0.28 10.8 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding PHP PF02811.19 ACT03416.1 - 8.7e-16 58.7 0.0 1.4e-15 57.9 0.0 1.4 1 1 0 1 1 1 1 PHP domain PHP_C PF13263.6 ACT03416.1 - 0.012 15.4 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 PHP-associated EamA PF00892.20 ACT03417.1 - 9.3e-19 68.0 30.4 4.4e-12 46.4 12.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family Mg_trans_NIPA PF05653.14 ACT03417.1 - 0.00012 21.3 2.9 0.00012 21.3 2.9 2.2 2 0 0 2 2 2 2 Magnesium transporter NIPA Multi_Drug_Res PF00893.19 ACT03417.1 - 0.0022 18.6 11.8 0.47 11.1 0.8 3.5 2 1 1 3 3 3 2 Small Multidrug Resistance protein TMEM234 PF10639.9 ACT03417.1 - 0.027 14.5 2.1 5.2 7.1 0.4 2.4 2 0 0 2 2 2 0 Putative transmembrane family 234 EXS PF03124.14 ACT03417.1 - 0.061 12.6 2.8 0.052 12.9 1.5 1.4 1 1 0 1 1 1 0 EXS family Phage_holin_2_1 PF04971.12 ACT03417.1 - 4.3 7.4 10.0 1.1 9.3 0.2 3.4 4 0 0 4 4 4 0 Bacteriophage P21 holin S DoxX PF07681.12 ACT03418.1 - 5.9e-19 68.4 11.6 5.9e-19 68.4 11.6 1.6 2 0 0 2 2 2 1 DoxX HxlR PF01638.17 ACT03419.1 - 1.4e-33 114.6 0.7 1.6e-33 114.4 0.7 1.0 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_34 PF13601.6 ACT03419.1 - 0.028 14.6 0.0 0.038 14.2 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain PadR PF03551.14 ACT03419.1 - 0.03 14.3 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family Replic_Relax PF13814.6 ACT03419.1 - 0.091 12.8 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Replication-relaxation Fer2_3 PF13085.6 ACT03420.1 - 1.6e-28 98.9 0.5 3.8e-28 97.7 0.0 1.8 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.6 ACT03420.1 - 2e-10 40.9 5.5 8.2e-10 39.0 3.2 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ACT03420.1 - 1.7e-09 37.6 3.2 1.7e-09 37.6 3.2 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 ACT03420.1 - 5.9e-08 33.2 6.2 8.1e-05 23.1 0.1 3.2 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 ACT03420.1 - 2e-06 27.8 6.6 0.00073 19.6 0.1 3.3 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 ACT03420.1 - 5.4e-06 26.8 5.4 5.4e-06 26.8 5.4 2.6 1 1 2 3 3 3 2 4Fe-4S dicluster domain Fer4 PF00037.27 ACT03420.1 - 0.00046 19.9 3.3 0.00046 19.9 3.3 3.5 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_2 PF12797.7 ACT03420.1 - 0.0019 18.2 1.5 0.0019 18.2 1.5 3.5 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_13 PF13370.6 ACT03420.1 - 0.0044 17.5 0.1 0.0044 17.5 0.1 2.7 3 0 0 3 3 2 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_4 PF12800.7 ACT03420.1 - 0.019 15.4 1.0 0.019 15.4 1.0 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_20 PF14691.6 ACT03420.1 - 0.024 14.4 9.3 0.4 10.5 0.9 3.1 2 1 1 3 3 3 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_6 PF12837.7 ACT03420.1 - 0.027 14.5 15.7 0.09 12.9 1.2 3.5 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_16 PF13484.6 ACT03420.1 - 0.039 14.9 13.8 0.15 13.0 3.0 3.1 2 1 2 4 4 4 0 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 ACT03420.1 - 0.057 13.5 0.7 0.057 13.5 0.7 3.3 3 1 0 3 3 3 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 ACT03420.1 - 0.13 13.2 0.7 0.13 13.2 0.7 3.4 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_15 PF13459.6 ACT03420.1 - 0.17 12.7 2.2 0.63 10.8 0.4 2.4 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_18 PF13746.6 ACT03420.1 - 0.49 10.6 11.1 3.1 8.0 2.2 2.9 2 1 1 3 3 3 0 4Fe-4S dicluster domain FAD_binding_2 PF00890.24 ACT03421.1 - 1.8e-86 290.9 0.2 2.4e-86 290.4 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 ACT03421.1 - 4e-42 143.2 0.1 6.2e-42 142.6 0.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 ACT03421.1 - 7.5e-05 22.0 1.0 7.5e-05 22.0 1.0 2.1 3 0 0 3 3 3 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 ACT03421.1 - 0.00012 21.4 2.2 0.03 13.6 1.1 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ACT03421.1 - 0.0006 18.6 0.3 0.0006 18.6 0.3 2.2 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.6 ACT03421.1 - 0.0054 16.9 0.6 0.017 15.3 0.6 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain THP2 PF09432.10 ACT03421.1 - 0.012 15.7 3.7 0.023 14.7 3.7 1.5 1 0 0 1 1 1 0 Tho complex subunit THP2 FAD_oxidored PF12831.7 ACT03421.1 - 0.013 14.9 1.7 0.013 14.9 1.7 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 ACT03421.1 - 0.027 13.8 1.3 0.26 10.6 1.3 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 ACT03421.1 - 0.064 12.5 0.3 0.19 10.9 0.5 1.6 2 0 0 2 2 2 0 FAD binding domain Sdh_cyt PF01127.22 ACT03422.1 - 3.7e-17 62.5 16.5 2.5e-13 50.1 9.0 2.1 1 1 1 2 2 2 2 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF1304 PF06993.12 ACT03422.1 - 0.025 14.6 6.5 0.055 13.5 3.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1304) TraQ PF09679.10 ACT03422.1 - 3.7 7.5 5.3 1.7 8.6 1.0 2.4 3 1 0 3 3 3 0 Type-F conjugative transfer system pilin chaperone (TraQ) LysR_substrate PF03466.20 ACT03423.1 - 3.9e-41 140.7 0.1 4.8e-41 140.4 0.1 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT03423.1 - 1.6e-21 76.0 0.4 2e-19 69.3 0.2 2.7 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family SBP_bac_3 PF00497.20 ACT03423.1 - 0.0073 15.7 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 HTH_8 PF02954.19 ACT03423.1 - 0.049 13.4 0.0 0.099 12.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Maf1 PF09174.10 ACT03423.1 - 0.064 13.4 0.0 0.2 11.8 0.0 1.5 1 1 0 1 1 1 0 Maf1 regulator HsbA PF12296.8 ACT03423.1 - 0.068 13.6 0.2 0.14 12.6 0.2 1.5 1 0 0 1 1 1 0 Hydrophobic surface binding protein A TrkA_N PF02254.18 ACT03425.1 - 1.7e-28 99.2 0.6 3.9e-28 98.0 0.1 1.8 2 0 0 2 2 2 1 TrkA-N domain TrkA_C PF02080.21 ACT03425.1 - 3.2e-13 49.3 0.6 1.7e-11 43.8 0.0 3.3 3 1 1 4 4 4 1 TrkA-C domain NAD_binding_2 PF03446.15 ACT03425.1 - 0.00016 21.9 0.3 0.00034 20.8 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACT03425.1 - 0.00048 20.7 0.0 0.0029 18.2 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 ACT03425.1 - 0.0028 17.1 0.0 0.0034 16.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 ACT03425.1 - 0.0043 17.0 0.2 0.53 10.3 0.0 2.9 2 1 1 3 3 3 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 ACT03425.1 - 0.0051 16.4 0.1 0.014 14.9 0.0 1.7 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 ACT03425.1 - 0.0054 16.1 0.0 0.0097 15.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ACT03425.1 - 0.037 13.9 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 ACT03425.1 - 0.044 13.0 0.1 0.068 12.4 0.1 1.4 1 1 0 1 1 1 0 FAD binding domain ApbA PF02558.16 ACT03425.1 - 0.067 12.8 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkH PF02386.16 ACT03426.1 - 7.5e-66 222.6 32.3 1e-65 222.2 32.3 1.1 1 0 0 1 1 1 1 Cation transport protein GRA6 PF05084.13 ACT03426.1 - 0.14 12.1 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Granule antigen protein (GRA6) Phage_holin_1 PF04531.13 ACT03426.1 - 0.72 10.4 0.1 0.72 10.4 0.1 3.1 3 1 0 3 3 3 0 Bacteriophage holin CPBP PF02517.16 ACT03427.1 - 6.3e-11 42.5 8.0 6.3e-11 42.5 8.0 3.7 3 1 0 3 3 3 1 CPBP intramembrane metalloprotease Colicin_K PF17500.2 ACT03427.1 - 0.12 13.0 5.7 0.049 14.2 2.3 2.1 2 0 0 2 2 2 0 Colicin-K MamL-1 PF09596.10 ACT03428.1 - 0.043 14.1 3.9 1.5 9.2 0.1 2.3 2 0 0 2 2 2 0 MamL-1 domain UvrC_HhH_N PF08459.11 ACT03430.1 - 1.4e-57 193.9 0.0 2.6e-57 193.0 0.0 1.5 1 0 0 1 1 1 1 UvrC Helix-hairpin-helix N-terminal GIY-YIG PF01541.24 ACT03430.1 - 1.9e-09 37.7 0.3 4.9e-09 36.3 0.3 1.8 1 0 0 1 1 1 1 GIY-YIG catalytic domain UVR PF02151.19 ACT03430.1 - 2.2e-08 33.6 5.3 4.4e-08 32.6 4.3 2.2 1 1 0 1 1 1 1 UvrB/uvrC motif HHH_2 PF12826.7 ACT03430.1 - 6.8e-07 29.3 0.1 2.1e-06 27.7 0.1 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 ACT03430.1 - 1.4e-05 25.6 0.8 3.8e-05 24.2 0.8 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.23 ACT03430.1 - 0.014 15.2 0.1 1.1 9.3 0.0 3.1 2 1 0 2 2 2 0 Helix-hairpin-helix motif 5_3_exonuc PF01367.20 ACT03430.1 - 0.017 15.7 0.6 0.048 14.3 0.1 2.0 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold CdiI_2 PF18593.1 ACT03430.1 - 0.07 13.8 0.2 24 5.6 0.0 3.4 3 0 0 3 3 3 0 CdiI immunity protein YqzM PF14141.6 ACT03431.1 - 0.00017 21.5 0.7 0.0002 21.3 0.7 1.1 1 0 0 1 1 1 1 YqzM-like protein DUF2292 PF10055.9 ACT03432.1 - 2.2e-17 62.4 0.2 3e-17 62.0 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized small protein (DUF2292) Leucyl-specific PF14795.6 ACT03432.1 - 0.13 12.4 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Leucine-tRNA synthetase-specific domain BPD_transp_1 PF00528.22 ACT03433.1 - 2.4e-14 53.5 13.5 2.4e-14 53.5 13.5 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2273 PF10031.9 ACT03433.1 - 0.01 15.8 0.0 0.01 15.8 0.0 3.5 4 0 0 4 4 4 0 Small integral membrane protein (DUF2273) DUF4181 PF13789.6 ACT03433.1 - 0.87 9.9 0.0 0.87 9.9 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4181) BPD_transp_1 PF00528.22 ACT03434.1 - 2e-25 89.6 15.8 2e-25 89.6 15.8 1.8 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_11 PF13531.6 ACT03435.1 - 3.5e-45 154.6 0.2 4.2e-45 154.3 0.2 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT03435.1 - 6.3e-05 22.5 0.3 0.00011 21.8 0.3 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein PBP_like PF12727.7 ACT03435.1 - 0.0046 16.1 0.0 0.0093 15.1 0.0 1.5 1 0 0 1 1 1 1 PBP superfamily domain LPAM_2 PF13627.6 ACT03435.1 - 0.24 11.3 1.4 0.43 10.5 1.4 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site ABC_tran PF00005.27 ACT03436.1 - 2.1e-30 106.1 0.0 2.7e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 ACT03436.1 - 5.6e-20 71.6 0.7 9.8e-20 70.8 0.7 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region SMC_N PF02463.19 ACT03436.1 - 0.001 18.5 0.1 0.0092 15.4 0.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT03436.1 - 0.0016 18.7 0.8 0.01 16.1 0.8 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ACT03436.1 - 0.0026 18.2 0.1 0.027 14.9 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ACT03436.1 - 0.018 15.4 0.1 0.027 14.9 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ACT03436.1 - 0.019 14.7 0.1 0.034 13.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT03436.1 - 0.024 14.5 0.2 0.044 13.7 0.2 1.3 1 0 0 1 1 1 0 RsgA GTPase Mg_chelatase PF01078.21 ACT03436.1 - 0.042 13.2 0.0 0.081 12.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 ACT03436.1 - 0.083 12.1 0.1 0.13 11.4 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 ACT03436.1 - 0.11 12.1 0.0 6.2 6.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ACT03436.1 - 0.14 12.2 0.2 0.36 10.9 0.1 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase ATP-synt_ab PF00006.25 ACT03436.1 - 0.2 11.3 0.0 0.3 10.7 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain ABC_tran PF00005.27 ACT03437.1 - 1.1e-25 90.8 0.0 1.4e-25 90.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 ACT03437.1 - 2.1e-19 69.8 0.2 3.7e-19 69.0 0.2 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 ACT03437.1 - 0.00011 22.2 1.1 0.0007 19.5 0.1 2.0 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT03437.1 - 0.00083 18.9 0.7 0.0045 16.5 0.7 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_7 PF12775.7 ACT03437.1 - 0.003 17.1 0.0 0.0046 16.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region TniB PF05621.11 ACT03437.1 - 0.0084 15.5 0.6 0.042 13.3 0.1 2.0 2 0 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 ACT03437.1 - 0.0084 16.4 1.0 1.2 9.4 0.2 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ACT03437.1 - 0.029 14.7 0.2 0.044 14.2 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ACT03437.1 - 0.04 13.7 0.1 0.07 12.9 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 ACT03437.1 - 0.098 12.0 0.1 0.65 9.3 0.1 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RsgA_GTPase PF03193.16 ACT03437.1 - 0.1 12.5 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase BPD_transp_1 PF00528.22 ACT03438.1 - 1.2e-30 106.7 13.0 1.2e-30 106.7 13.0 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 ACT03438.1 - 3.8e-10 39.6 0.4 3.8e-10 39.6 0.4 3.6 3 1 0 3 3 3 1 N-terminal TM domain of oligopeptide transport permease C DUF3169 PF11368.8 ACT03438.1 - 2 7.9 8.4 0.36 10.3 4.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) BPD_transp_1 PF00528.22 ACT03439.1 - 2.9e-38 131.4 9.2 2.9e-38 131.4 9.2 1.6 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_5 PF00496.22 ACT03440.1 - 1.6e-91 307.1 13.2 2.4e-91 306.5 13.2 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle DUF3558 PF12079.8 ACT03440.1 - 3.2 7.7 5.2 5.8 6.9 5.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) IstB_IS21 PF01695.17 ACT03441.1 - 1.5e-14 54.1 0.0 2.2e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein DnaI_N PF07319.11 ACT03441.1 - 9.5e-10 39.0 1.1 2.4e-09 37.7 0.0 2.2 2 0 0 2 2 2 1 Primosomal protein DnaI N-terminus AFG1_ATPase PF03969.16 ACT03441.1 - 1.1e-05 24.6 0.0 1.4e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 AFG1-like ATPase Bac_DnaA PF00308.18 ACT03441.1 - 0.00028 20.8 0.0 0.00043 20.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial dnaA protein ATPase PF06745.13 ACT03441.1 - 0.0029 17.0 0.1 0.0057 16.0 0.1 1.4 1 0 0 1 1 1 1 KaiC AAA PF00004.29 ACT03441.1 - 0.0087 16.5 0.0 0.019 15.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 ACT03441.1 - 0.0087 16.0 0.5 0.14 12.0 0.0 2.4 2 1 1 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B ResIII PF04851.15 ACT03441.1 - 0.014 15.4 0.0 0.029 14.4 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 ACT03441.1 - 0.019 15.3 0.0 0.053 13.9 0.0 1.9 1 0 0 1 1 1 0 RNA helicase cobW PF02492.19 ACT03441.1 - 0.038 13.6 0.0 0.068 12.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF3301 PF11743.8 ACT03441.1 - 0.043 13.5 0.5 7.9 6.2 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3301) AAA_25 PF13481.6 ACT03441.1 - 0.059 12.9 1.3 1.1 8.9 0.2 2.4 1 1 1 2 2 2 0 AAA domain TsaE PF02367.17 ACT03441.1 - 0.069 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ACT03441.1 - 0.08 12.8 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 ACT03441.1 - 0.1 13.0 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ACT03441.1 - 0.16 12.2 0.5 0.88 9.8 0.1 2.3 2 1 1 3 3 3 0 AAA domain DnaB_2 PF07261.11 ACT03442.1 - 0.00051 19.7 0.1 0.0015 18.3 0.1 1.7 1 0 0 1 1 1 1 Replication initiation and membrane attachment YuiB PF14068.6 ACT03443.1 - 5.5e-26 91.1 14.0 3.8e-25 88.4 14.0 1.8 1 1 0 1 1 1 1 Putative membrane protein EcsC PF12787.7 ACT03443.1 - 0.013 15.2 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 EcsC protein family PRRSV_2b PF07069.11 ACT03443.1 - 0.026 15.0 0.5 0.026 15.0 0.5 2.2 1 1 1 2 2 2 0 Porcine reproductive and respiratory syndrome virus 2b UPF0014 PF03649.13 ACT03443.1 - 0.81 9.0 7.9 1.5 8.1 4.6 1.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0014) Chlor_dismutase PF06778.12 ACT03444.1 - 1.7e-75 252.9 0.1 2.1e-75 252.6 0.1 1.1 1 0 0 1 1 1 1 Chlorite dismutase Pyr_redox_2 PF07992.14 ACT03446.1 - 3.3e-44 151.3 0.0 3.9e-44 151.1 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT03446.1 - 2.1e-09 37.8 0.2 4.2e-06 27.2 0.0 3.1 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT03446.1 - 0.00012 21.8 0.0 0.031 13.9 0.0 2.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ACT03446.1 - 0.0076 16.2 0.0 1.8 8.5 0.0 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 ACT03446.1 - 0.013 14.4 0.0 0.024 13.5 0.0 1.4 1 0 0 1 1 1 0 Tryptophan halogenase NAD_binding_8 PF13450.6 ACT03446.1 - 0.019 15.2 0.4 0.046 14.0 0.0 1.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ACT03447.1 - 1.6e-32 112.9 0.7 1.9e-32 112.7 0.7 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACT03447.1 - 2.2e-25 89.6 6.1 3.3e-23 82.4 0.3 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT03447.1 - 5.7e-14 52.4 3.3 2.5e-10 40.8 0.0 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ACT03447.1 - 1.3e-11 43.8 4.3 9.8e-07 27.8 0.8 3.6 4 0 0 4 4 4 2 HI0933-like protein FAD_oxidored PF12831.7 ACT03447.1 - 3.7e-06 26.5 1.0 4.8e-06 26.2 0.1 1.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ACT03447.1 - 3.5e-05 23.1 4.3 0.00056 19.1 0.2 3.1 2 1 1 4 4 4 1 FAD binding domain NAD_binding_8 PF13450.6 ACT03447.1 - 4.9e-05 23.5 0.1 0.00011 22.4 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 ACT03447.1 - 5.3e-05 22.5 1.8 0.00033 19.9 0.3 2.5 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 ACT03447.1 - 0.00059 19.5 5.3 0.031 13.8 0.3 3.0 1 1 1 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 ACT03447.1 - 0.00078 18.8 0.7 0.0022 17.3 0.1 2.0 2 0 0 2 2 2 1 Thi4 family Amino_oxidase PF01593.24 ACT03447.1 - 0.0012 18.2 1.2 0.12 11.7 0.0 3.0 2 1 1 3 3 3 1 Flavin containing amine oxidoreductase GIDA PF01134.22 ACT03447.1 - 0.0017 17.5 4.1 0.32 10.0 0.1 3.6 4 0 0 4 4 4 1 Glucose inhibited division protein A MCRA PF06100.11 ACT03447.1 - 0.0053 15.6 0.2 0.0082 15.0 0.0 1.3 2 0 0 2 2 2 1 MCRA family AlaDh_PNT_C PF01262.21 ACT03447.1 - 0.045 13.0 2.4 0.09 12.1 0.5 2.6 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 ACT03447.1 - 0.084 11.7 0.6 0.33 9.7 0.1 2.0 2 0 0 2 2 2 0 Tryptophan halogenase FAD_binding_3 PF01494.19 ACT03447.1 - 0.12 11.6 1.0 0.28 10.4 0.2 1.8 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 ACT03447.1 - 0.13 11.3 0.2 0.25 10.3 0.1 1.5 1 1 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 ACT03447.1 - 0.95 9.4 5.3 35 4.3 0.1 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding zinc-ribbons_6 PF07191.12 ACT03448.1 - 0.026 14.5 3.1 0.39 10.7 0.4 2.2 2 0 0 2 2 2 0 zinc-ribbons Nudix_N_2 PF14803.6 ACT03448.1 - 0.044 13.7 5.0 9.4 6.2 0.1 3.3 3 0 0 3 3 3 0 Nudix N-terminal zinc_ribbon_2 PF13240.6 ACT03448.1 - 0.045 13.5 4.8 6.3 6.7 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf-CHY PF05495.12 ACT03448.1 - 0.098 13.2 6.3 1.7 9.2 6.3 2.0 1 1 0 1 1 1 0 CHY zinc finger zf-C3HC4_3 PF13920.6 ACT03448.1 - 0.19 11.6 8.2 0.3 11.0 0.2 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-TFIIB PF13453.6 ACT03448.1 - 0.37 10.2 3.6 28 4.1 0.0 3.1 3 0 0 3 3 3 0 Transcription factor zinc-finger zf-ribbon_3 PF13248.6 ACT03448.1 - 0.37 10.3 10.1 0.12 11.8 2.4 2.9 3 0 0 3 3 3 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 ACT03448.1 - 0.39 10.9 5.7 7.6 6.7 0.1 3.1 2 1 1 3 3 3 0 Zinc ribbon domain zf-MYND PF01753.18 ACT03448.1 - 0.56 10.3 7.2 5.3 7.2 0.9 2.3 2 0 0 2 2 2 0 MYND finger DZR PF12773.7 ACT03448.1 - 0.71 10.0 9.5 19 5.3 9.5 2.4 1 1 0 1 1 1 0 Double zinc ribbon zf-LITAF-like PF10601.9 ACT03448.1 - 1.8 8.9 6.9 7.5 6.9 1.5 2.4 2 1 0 2 2 2 0 LITAF-like zinc ribbon domain zf_UBZ PF18439.1 ACT03448.1 - 1.8 8.2 4.8 3.1 7.5 0.1 2.8 2 1 1 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-WRNIP1_ubi PF18279.1 ACT03448.1 - 3.1 8.6 7.5 36 5.3 4.7 2.9 2 1 1 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain TF_Zn_Ribbon PF08271.12 ACT03448.1 - 7.2 6.2 9.4 28 4.4 4.2 3.0 2 1 0 2 2 2 0 TFIIB zinc-binding Sda PF08970.10 ACT03449.1 - 3.4e-12 45.9 3.9 3.7e-12 45.8 3.9 1.0 1 0 0 1 1 1 1 Sporulation inhibitor A ATPgrasp_YheCD PF14398.6 ACT03450.1 - 3.6e-56 190.3 0.0 4.3e-56 190.0 0.0 1.0 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACT03450.1 - 3.8e-09 36.2 0.1 7.7e-05 22.1 0.1 2.2 2 1 0 2 2 2 2 Sugar-transfer associated ATP-grasp GSH-S_ATP PF02955.16 ACT03450.1 - 6.2e-05 22.5 0.1 0.0003 20.2 0.0 2.1 1 1 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.14 ACT03450.1 - 0.0011 19.1 0.0 0.07 13.2 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain TTL PF03133.15 ACT03450.1 - 0.12 11.5 0.0 1.4 8.0 0.0 2.0 2 0 0 2 2 2 0 Tubulin-tyrosine ligase family CPSase_L_D2 PF02786.17 ACT03450.1 - 0.15 11.5 0.0 5.4 6.5 0.0 2.1 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Topoisom_bac PF01131.20 ACT03451.1 - 1.3e-127 426.3 0.6 1.6e-127 425.9 0.6 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 ACT03451.1 - 1.1e-14 54.5 0.0 3.1e-14 53.0 0.0 1.8 1 0 0 1 1 1 1 Toprim domain zf-C4_Topoisom PF01396.19 ACT03451.1 - 1.3e-05 24.9 10.7 0.0017 18.1 1.4 2.5 2 0 0 2 2 2 2 Topoisomerase DNA binding C4 zinc finger RNA_POL_M_15KD PF02150.16 ACT03451.1 - 0.0019 18.0 9.2 0.3 11.0 1.4 2.5 2 0 0 2 2 2 2 RNA polymerases M/15 Kd subunit GFA PF04828.14 ACT03451.1 - 0.41 11.0 3.3 1.5 9.2 0.1 2.6 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme OrfB_Zn_ribbon PF07282.11 ACT03451.1 - 0.62 10.0 10.1 1.6 8.7 1.3 2.5 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 ACT03451.1 - 0.76 9.3 3.7 4.6 6.8 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain YhfH PF14149.6 ACT03451.1 - 4.2 7.4 7.5 7 6.7 0.2 2.5 2 0 0 2 2 2 0 YhfH-like protein zinc-ribbons_6 PF07191.12 ACT03451.1 - 4.9 7.2 9.3 22 5.1 9.4 1.9 1 1 1 2 2 2 0 zinc-ribbons Auto_anti-p27 PF06677.12 ACT03451.1 - 5 7.4 6.4 1.8 8.8 0.3 2.8 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) HypA PF01155.19 ACT03451.1 - 5.2 7.1 7.1 99 3.0 5.7 2.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ISL3 PF14690.6 ACT03451.1 - 7.5 7.3 8.9 13 6.5 0.1 2.6 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Metallophos PF00149.28 ACT03452.1 - 1.2e-13 52.0 0.2 2.4e-13 51.1 0.2 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACT03452.1 - 9.5e-09 35.7 0.1 1.4e-08 35.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF4407 PF14362.6 ACT03453.1 - 0.027 13.8 14.4 14 4.9 14.4 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PKHD_C PF18331.1 ACT03453.1 - 0.12 12.5 1.5 2.6 8.2 2.7 2.6 2 1 0 2 2 2 0 PKHD-type hydroxylase C-terminal domain FAM76 PF16046.5 ACT03453.1 - 0.28 10.5 9.0 0.013 14.9 1.3 2.3 2 1 1 3 3 3 0 FAM76 protein ATG16 PF08614.11 ACT03453.1 - 0.3 11.3 28.0 9.9 6.3 0.1 4.1 3 1 1 4 4 4 0 Autophagy protein 16 (ATG16) SlyX PF04102.12 ACT03453.1 - 0.38 11.4 0.0 0.38 11.4 0.0 4.7 4 1 0 4 4 4 0 SlyX FadA PF09403.10 ACT03453.1 - 3.8 8.0 21.6 1 9.9 10.6 4.4 3 1 1 4 4 4 0 Adhesion protein FadA FtsX PF02687.21 ACT03454.1 - 2.1e-10 41.0 52.6 2.6e-09 37.4 9.9 6.2 5 1 1 6 6 6 3 FtsX-like permease family ABC_tran PF00005.27 ACT03455.1 - 9.6e-30 103.9 0.0 1.4e-29 103.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT03455.1 - 3.1e-07 30.5 0.0 0.0036 17.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ACT03455.1 - 2e-05 24.3 0.2 0.26 10.8 0.0 2.6 3 0 0 3 3 3 2 AAA domain SMC_N PF02463.19 ACT03455.1 - 0.00024 20.6 0.3 0.2 11.0 0.1 2.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACT03455.1 - 0.0008 19.8 0.1 0.0015 19.0 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ACT03455.1 - 0.0011 18.8 0.0 0.0022 17.9 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ACT03455.1 - 0.0029 17.9 0.3 0.061 13.6 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_29 PF13555.6 ACT03455.1 - 0.007 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ACT03455.1 - 0.0076 16.0 0.2 0.026 14.3 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ACT03455.1 - 0.008 16.7 0.0 0.015 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 ACT03455.1 - 0.0082 16.1 0.1 2.9 7.8 0.0 2.2 2 0 0 2 2 2 2 NTPase AAA_28 PF13521.6 ACT03455.1 - 0.013 15.7 0.2 0.086 13.1 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ACT03455.1 - 0.03 14.9 0.3 0.059 13.9 0.3 1.7 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ACT03455.1 - 0.043 14.3 0.6 0.41 11.1 0.6 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 ACT03455.1 - 0.051 13.2 0.1 0.096 12.3 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 ACT03455.1 - 0.059 12.4 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein MMR_HSR1 PF01926.23 ACT03455.1 - 0.097 12.8 0.4 0.15 12.2 0.4 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_15 PF13175.6 ACT03455.1 - 0.12 12.0 0.0 0.38 10.4 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 ACT03455.1 - 0.16 11.1 0.0 0.4 9.8 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain AAA_33 PF13671.6 ACT03455.1 - 0.17 12.0 0.1 0.57 10.3 0.1 1.7 2 0 0 2 2 2 0 AAA domain HATPase_c PF02518.26 ACT03456.1 - 9.4e-18 64.8 0.0 1.7e-17 64.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT03456.1 - 0.00039 20.4 0.2 0.00077 19.5 0.2 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 ACT03456.1 - 0.024 14.6 0.0 0.057 13.4 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACT03456.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Trans_reg_C PF00486.28 ACT03457.1 - 4.5e-23 81.1 0.2 7.2e-23 80.5 0.2 1.3 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 ACT03457.1 - 2.6e-21 75.9 0.0 5.7e-21 74.8 0.0 1.6 2 0 0 2 2 2 1 Response regulator receiver domain DUF5050 PF16472.5 ACT03458.1 - 3.8e-07 29.6 5.6 0.00077 18.8 0.4 2.2 1 1 0 2 2 2 2 Domain of unknown function (DUF5050) PD40 PF07676.12 ACT03458.1 - 0.0002 21.2 2.3 7.4 6.6 0.0 4.4 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Cu_amine_oxidN1 PF07833.11 ACT03458.1 - 0.073 13.6 1.5 1.2 9.6 0.1 3.2 2 1 1 3 3 3 0 Copper amine oxidase N-terminal domain POLO_box PF00659.18 ACT03458.1 - 0.085 13.1 0.4 6.2 7.1 0.1 3.5 3 1 1 4 4 4 0 POLO box duplicated region PBP_like_2 PF12849.7 ACT03459.1 - 6.3e-31 108.1 12.3 1.8e-30 106.6 12.3 1.6 1 1 0 1 1 1 1 PBP superfamily domain PBP_like PF12727.7 ACT03459.1 - 4e-20 71.8 0.2 6.4e-20 71.1 0.2 1.4 1 0 0 1 1 1 1 PBP superfamily domain BPD_transp_1 PF00528.22 ACT03460.1 - 1.7e-20 73.6 18.7 1.7e-20 73.6 18.7 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2627 PF11118.8 ACT03460.1 - 0.5 11.0 6.2 9.4 6.9 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2627) BPD_transp_1 PF00528.22 ACT03461.1 - 4e-26 91.9 13.5 4e-26 91.9 13.5 2.5 1 1 2 3 3 3 1 Binding-protein-dependent transport system inner membrane component Fe-S_biosyn PF01521.20 ACT03462.1 - 3e-21 75.7 0.0 3.4e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Radical_SAM PF04055.21 ACT03463.1 - 1.9e-16 60.9 0.0 3.7e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 ACT03463.1 - 0.043 14.1 0.0 0.076 13.3 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S single cluster domain Pyr_redox_2 PF07992.14 ACT03464.1 - 3.2e-35 121.8 0.0 3.7e-35 121.6 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT03464.1 - 2.2e-09 37.8 0.1 2.3e-07 31.3 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ACT03464.1 - 9.8e-06 24.8 0.0 0.00052 19.2 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 ACT03464.1 - 2.9e-05 24.2 0.1 0.0094 16.2 0.0 2.4 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ACT03464.1 - 0.00012 22.1 0.0 0.066 13.2 0.0 2.7 3 0 0 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 ACT03464.1 - 0.00015 21.1 0.0 0.0008 18.6 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 ACT03464.1 - 0.00056 19.3 0.0 0.00095 18.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT03464.1 - 0.0017 18.1 0.2 0.14 11.7 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase TrkA_N PF02254.18 ACT03464.1 - 0.017 15.4 0.3 5.1 7.4 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain Trp_halogenase PF04820.14 ACT03464.1 - 0.05 12.4 0.2 7.4 5.3 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase DUF1450 PF07293.11 ACT03465.1 - 4.8e-30 103.2 0.1 5.3e-30 103.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1450) 2Fe-2S_thioredx PF01257.19 ACT03465.1 - 0.059 13.2 0.1 0.075 12.9 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin NifU PF01106.17 ACT03466.1 - 3.8e-28 97.4 0.4 4.5e-28 97.2 0.4 1.1 1 0 0 1 1 1 1 NifU-like domain YebG PF07130.12 ACT03466.1 - 0.11 12.3 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 YebG protein adh_short_C2 PF13561.6 ACT03467.1 - 4.2e-46 157.4 0.0 4.8e-46 157.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT03467.1 - 5.6e-42 143.4 0.0 6.9e-42 143.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT03467.1 - 6.3e-08 32.7 0.2 1e-07 32.0 0.1 1.4 2 0 0 2 2 2 1 KR domain HEPN_Cthe2314 PF18730.1 ACT03468.1 - 1.5e-50 171.7 3.4 1.9e-50 171.3 3.4 1.1 1 0 0 1 1 1 1 Cthe_2314-like HEPN HEPN_LA2681 PF18733.1 ACT03468.1 - 0.0046 16.3 3.9 0.0098 15.2 3.8 1.6 1 1 0 1 1 1 1 LA2681-like HEPN DUF1870 PF08965.10 ACT03468.1 - 0.012 15.6 3.2 0.75 9.8 0.3 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF1870) DUF4145 PF13643.6 ACT03468.1 - 0.1 12.7 0.4 2 8.6 0.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4145) UbiD PF01977.16 ACT03469.1 - 9.6e-133 443.0 0.0 1.7e-129 432.2 0.0 2.0 2 0 0 2 2 2 2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase COX15-CtaA PF02628.15 ACT03470.1 - 4.9e-29 101.4 23.0 1.2e-20 73.9 16.7 3.8 1 1 1 2 2 2 2 Cytochrome oxidase assembly protein CPP1-like PF11833.8 ACT03470.1 - 0.0089 15.7 10.2 0.24 11.0 1.6 2.4 2 0 0 2 2 2 2 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF2070 PF09843.9 ACT03470.1 - 0.011 14.1 6.5 0.012 14.0 6.0 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) Ni_hydr_CYTB PF01292.20 ACT03470.1 - 0.63 9.6 20.8 0.09 12.4 7.4 3.1 1 1 1 3 3 3 0 Prokaryotic cytochrome b561 DUF2231 PF09990.9 ACT03470.1 - 3.8 8.0 9.6 0.12 12.8 1.8 2.5 2 2 0 2 2 2 0 Predicted membrane protein (DUF2231) Thioredoxin PF00085.20 ACT03471.1 - 4.1e-19 68.5 0.0 5e-19 68.2 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 ACT03471.1 - 2.8e-06 27.1 0.0 3.8e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ACT03471.1 - 0.0014 19.1 0.1 0.006 17.0 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ACT03471.1 - 0.029 14.7 0.1 0.57 10.5 0.1 2.2 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_3 PF13192.6 ACT03471.1 - 0.14 12.3 0.0 0.32 11.1 0.0 1.7 1 1 1 2 2 2 0 Thioredoxin domain Glutaredoxin PF00462.24 ACT03471.1 - 0.15 12.3 0.4 0.75 10.1 0.0 2.2 2 1 0 2 2 2 0 Glutaredoxin Endonuclease_5 PF04493.14 ACT03471.1 - 0.19 11.4 0.0 0.2 11.3 0.0 1.3 1 1 0 1 1 1 0 Endonuclease V Cu_amine_oxidN1 PF07833.11 ACT03472.1 - 1.6e-19 70.2 1.3 4.1e-19 68.9 0.7 2.0 2 0 0 2 2 2 1 Copper amine oxidase N-terminal domain Spc24 PF08286.11 ACT03472.1 - 0.062 13.5 1.8 1 9.6 0.2 2.5 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 LPAM_1 PF08139.12 ACT03472.1 - 0.093 13.3 0.2 0.18 12.4 0.2 1.5 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Polysacc_synt PF01943.17 ACT03473.1 - 7.7e-24 84.5 19.8 7.7e-24 84.5 19.8 3.0 2 1 1 3 3 3 1 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.6 ACT03473.1 - 6.3e-21 74.9 19.0 6.3e-21 74.9 19.0 4.7 4 1 0 5 5 5 1 Polysaccharide biosynthesis C-terminal domain MurJ PF03023.14 ACT03473.1 - 1e-09 37.6 28.7 1e-09 37.6 28.7 2.3 1 1 0 1 1 1 1 Lipid II flippase MurJ MatE PF01554.18 ACT03473.1 - 0.0003 20.5 9.0 0.0003 20.5 9.0 4.2 5 1 0 5 5 5 2 MatE ThuA PF06283.11 ACT03474.1 - 6.5e-35 121.3 0.9 7.7e-35 121.0 0.9 1.1 1 0 0 1 1 1 1 Trehalose utilisation DUF456 PF04306.13 ACT03475.1 - 1.9e-36 125.4 24.8 1.9e-36 125.4 24.8 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF456) Gly-zipper_Omp PF13488.6 ACT03475.1 - 0.27 11.3 7.0 0.25 11.4 2.2 2.5 1 1 2 3 3 3 0 Glycine zipper Gly-zipper_YMGG PF13441.6 ACT03475.1 - 0.75 9.6 4.2 2.2 8.1 0.6 2.6 2 1 0 2 2 2 0 YMGG-like Gly-zipper DUF1269 PF06897.12 ACT03475.1 - 5 7.5 11.7 0.15 12.4 5.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1269) Hydrolase_3 PF08282.12 ACT03476.1 - 7.6e-57 192.9 0.1 2.9e-30 105.9 0.8 2.0 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ACT03476.1 - 1.8e-17 63.7 0.0 7.2e-17 61.7 0.0 1.8 1 1 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 ACT03476.1 - 1.2e-08 35.5 0.2 0.0003 21.1 0.0 2.5 2 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT03476.1 - 0.00029 21.3 0.0 0.2 12.1 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ACT03476.1 - 0.0015 18.7 0.0 0.11 12.6 0.0 2.3 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase PDU_like PF15953.5 ACT03476.1 - 0.0032 17.6 0.0 0.0059 16.7 0.0 1.4 1 0 0 1 1 1 1 Putative propanediol utilisation Hydrolase_6 PF13344.6 ACT03476.1 - 0.015 15.4 0.1 0.093 12.9 0.0 2.3 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase Oxidored_nitro PF00148.19 ACT03476.1 - 0.087 11.5 0.1 0.14 10.8 0.1 1.3 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase ABC-3 PF00950.17 ACT03477.1 - 1e-51 175.9 39.4 2.5e-51 174.6 39.4 1.5 1 1 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 ACT03477.1 - 2.9e-07 29.8 38.0 1.2e-06 27.8 38.0 2.0 1 1 0 1 1 1 1 FecCD transport family ABC-3 PF00950.17 ACT03478.1 - 2.5e-72 243.5 25.6 2.9e-72 243.3 25.6 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 ACT03478.1 - 2.5e-09 36.6 28.1 3.4e-09 36.2 28.1 1.3 1 0 0 1 1 1 1 FecCD transport family PalH PF08733.10 ACT03478.1 - 0.12 11.3 1.3 0.19 10.7 1.3 1.3 1 0 0 1 1 1 0 PalH/RIM21 ABC_tran PF00005.27 ACT03479.1 - 8.6e-27 94.3 0.0 1.3e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT03479.1 - 1.1e-08 35.3 0.0 0.0029 17.5 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT03479.1 - 2.4e-07 30.4 2.8 0.001 18.6 0.2 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 ACT03479.1 - 0.00065 19.5 0.6 0.0018 18.0 0.6 1.8 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.6 ACT03479.1 - 0.0011 19.1 0.7 0.017 15.3 0.7 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 ACT03479.1 - 0.0025 17.5 0.1 0.0071 16.1 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_27 PF13514.6 ACT03479.1 - 0.0047 16.5 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT03479.1 - 0.017 15.5 0.1 0.049 14.0 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 ACT03479.1 - 0.022 15.3 0.4 0.054 14.0 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ACT03479.1 - 0.037 14.6 0.0 2 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 ACT03479.1 - 0.057 13.2 0.2 0.51 10.1 0.1 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 ACT03479.1 - 0.075 12.6 0.3 6.4 6.3 0.1 2.3 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ACT03479.1 - 0.1 12.5 0.4 12 5.8 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 ACT03479.1 - 0.11 12.6 0.2 0.32 11.1 0.2 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase MukB PF04310.12 ACT03479.1 - 0.26 11.1 1.3 0.99 9.2 0.2 2.0 2 0 0 2 2 2 0 MukB N-terminal MeaB PF03308.16 ACT03479.1 - 0.32 10.0 1.6 0.43 9.5 0.2 1.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 ACT03479.1 - 0.35 11.3 1.4 13 6.2 0.3 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ACT03479.1 - 0.66 9.7 2.1 1.8 8.2 0.2 2.2 2 1 0 2 2 2 0 AAA domain ZnuA PF01297.17 ACT03480.1 - 9.4e-73 244.8 0.0 1.1e-72 244.6 0.0 1.0 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic LPAM_2 PF13627.6 ACT03480.1 - 7.1 6.6 5.6 11 6.0 5.6 1.3 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Transpeptidase PF00905.22 ACT03481.1 - 2.4e-61 207.6 1.0 3.3e-61 207.1 1.0 1.2 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 ACT03481.1 - 7.5e-29 101.3 1.2 7.5e-29 101.3 1.2 1.7 2 0 0 2 2 2 1 Penicillin-binding Protein dimerisation domain Transglut_core PF01841.19 ACT03482.1 - 2.2e-21 76.4 0.2 4.1e-21 75.5 0.2 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 ACT03482.1 - 3.4e-05 23.4 0.2 0.0001 21.9 0.2 1.8 1 1 0 1 1 1 1 Transglutaminase-like domain Colicin_V PF02674.16 ACT03482.1 - 0.00021 21.3 15.9 0.007 16.3 15.9 2.8 1 1 0 1 1 1 1 Colicin V production protein Transglut_core3 PF13471.6 ACT03482.1 - 0.03 14.2 0.0 0.097 12.6 0.0 1.8 2 0 0 2 2 2 0 Transglutaminase-like superfamily E3_binding PF02817.17 ACT03482.1 - 0.048 14.0 0.7 0.12 12.8 0.1 2.0 2 0 0 2 2 2 0 e3 binding domain ATG22 PF11700.8 ACT03482.1 - 0.11 11.1 1.1 0.18 10.4 1.1 1.3 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Transglut_core2 PF13369.6 ACT03482.1 - 0.11 12.0 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Transglutaminase-like superfamily Wzy_C PF04932.15 ACT03483.1 - 0.0043 16.7 0.3 0.0045 16.6 0.3 1.2 1 0 0 1 1 1 1 O-Antigen ligase YfhO PF09586.10 ACT03483.1 - 0.0079 14.5 0.1 0.0091 14.3 0.1 1.2 1 0 0 1 1 1 1 Bacterial membrane protein YfhO Bax1-I PF01027.20 ACT03483.1 - 0.012 15.5 2.0 0.015 15.2 2.0 1.1 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 DUF4131 PF13567.6 ACT03483.1 - 0.013 15.1 0.1 0.016 14.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Spore_YabQ PF09578.10 ACT03483.1 - 0.017 15.3 6.1 0.024 14.8 6.1 1.2 1 0 0 1 1 1 0 Spore cortex protein YabQ (Spore_YabQ) Tweety PF04906.13 ACT03483.1 - 0.075 11.7 2.7 0.098 11.3 2.7 1.1 1 0 0 1 1 1 0 Tweety DUF3357 PF11837.8 ACT03483.1 - 5.3 7.5 5.8 0.64 10.5 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) MFS_1 PF07690.16 ACT03484.1 - 3.1e-36 125.0 53.3 3.8e-28 98.4 38.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ACT03484.1 - 4.4e-05 22.5 7.6 0.092 11.6 5.8 3.0 1 1 1 2 2 2 2 MFS_1 like family YjcZ_2 PF09680.10 ACT03485.1 - 0.033 13.8 9.4 0.065 12.9 9.4 1.5 1 0 0 1 1 1 0 Family of unknown function Shisa PF13908.6 ACT03485.1 - 0.22 11.8 0.3 0.18 12.0 0.3 1.0 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Toprim PF01751.22 ACT03486.1 - 0.0011 19.1 0.0 0.0035 17.5 0.0 1.7 1 1 0 1 1 1 1 Toprim domain Toprim_2 PF13155.6 ACT03486.1 - 0.0062 16.9 0.0 0.01 16.2 0.0 1.6 2 0 0 2 2 2 1 Toprim-like Toprim_4 PF13662.6 ACT03486.1 - 0.044 14.2 0.0 0.23 12.0 0.0 2.2 1 1 0 1 1 1 0 Toprim domain Toprim_3 PF13362.6 ACT03486.1 - 0.045 14.1 0.0 0.12 12.8 0.0 1.8 1 1 0 1 1 1 0 Toprim domain Mem_trans PF03547.18 ACT03487.1 - 3.3e-13 48.8 27.3 5.4e-12 44.8 10.7 2.1 1 1 1 2 2 2 2 Membrane transport protein SCO1-SenC PF02630.14 ACT03488.1 - 3e-24 85.4 0.0 3.7e-24 85.1 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 ACT03488.1 - 4e-09 36.4 0.0 7.9e-09 35.5 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ACT03488.1 - 3.1e-08 33.5 0.0 7.2e-08 32.3 0.0 1.6 1 1 0 1 1 1 1 Redoxin Sialidase PF02973.16 ACT03488.1 - 0.14 11.6 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Sialidase, N-terminal domain UbiA PF01040.18 ACT03489.1 - 3.3e-67 226.5 20.9 4e-67 226.2 20.9 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Spore_GerQ PF09671.10 ACT03490.1 - 1.3e-39 134.0 0.5 1.7e-39 133.7 0.5 1.1 1 0 0 1 1 1 1 Spore coat protein (Spore_GerQ) DUF1838 PF08894.11 ACT03491.1 - 0.037 13.7 0.0 0.046 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1838) YdjM PF04307.14 ACT03492.1 - 9.4e-27 93.4 11.5 1.4e-26 92.9 11.5 1.2 1 0 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase DUF4184 PF13803.6 ACT03492.1 - 0.00063 19.5 0.9 0.0012 18.7 0.2 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4184) SASP PF00269.20 ACT03493.1 - 9e-27 92.9 0.3 1e-26 92.7 0.3 1.0 1 0 0 1 1 1 1 Small, acid-soluble spore proteins, alpha/beta type DUF5325 PF17259.2 ACT03494.1 - 1.1e-08 34.8 3.6 1.2e-08 34.7 3.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5325) DUF2244 PF10003.9 ACT03494.1 - 0.00016 21.4 1.5 0.00018 21.2 1.5 1.0 1 0 0 1 1 1 1 Integral membrane protein (DUF2244) Phage_holin_3_6 PF07332.11 ACT03494.1 - 0.0016 18.4 2.0 0.0018 18.3 2.0 1.0 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III DUF4229 PF14012.6 ACT03494.1 - 0.028 14.5 2.7 0.033 14.3 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) DUF4199 PF13858.6 ACT03494.1 - 0.029 14.8 1.8 0.031 14.7 1.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF2207 PF09972.9 ACT03494.1 - 0.075 11.8 2.8 0.082 11.7 2.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2721 PF11026.8 ACT03494.1 - 0.13 12.2 4.8 0.14 12.1 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF3043 PF11241.8 ACT03494.1 - 0.13 12.3 0.4 0.15 12.0 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF4131 PF13567.6 ACT03494.1 - 0.19 11.3 1.5 0.2 11.3 1.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) PhoR PF11808.8 ACT03494.1 - 0.25 11.8 1.4 0.27 11.6 1.4 1.2 1 0 0 1 1 1 0 Phosphate regulon sensor protein PhoR DUF4190 PF13828.6 ACT03494.1 - 0.27 11.0 8.2 1.2 8.9 8.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4190) Halogen_Hydrol PF10112.9 ACT03494.1 - 0.53 10.3 1.7 0.57 10.2 1.7 1.0 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Gram_pos_anchor PF00746.21 ACT03494.1 - 1.5 8.9 4.1 0.59 10.1 0.2 2.0 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF202 PF02656.15 ACT03494.1 - 4.2 7.9 8.6 1.4e+02 3.0 10.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF202) YbgT_YccB PF08173.11 ACT03494.1 - 8.7 6.6 10.6 11 6.3 1.0 2.4 2 1 0 2 2 2 0 Membrane bound YbgT-like protein tRNA-synt_1b PF00579.25 ACT03495.1 - 3.3e-80 269.5 0.0 4e-80 269.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) ArsP_1 PF03773.13 ACT03496.1 - 5.5e-71 239.1 5.8 7.3e-71 238.7 5.8 1.2 1 0 0 1 1 1 1 Predicted permease ArsP_2 PF11449.8 ACT03496.1 - 7.2e-07 28.7 0.2 1.4e-05 24.5 0.0 2.0 1 1 0 2 2 2 1 Putative, 10TM heavy-metal exporter Myc_target_1 PF15179.6 ACT03496.1 - 0.0017 18.3 0.0 0.0044 16.9 0.0 1.7 1 0 0 1 1 1 1 Myc target protein 1 DUF1043 PF06295.12 ACT03496.1 - 0.097 12.7 0.2 0.22 11.5 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) DUF1761 PF08570.10 ACT03496.1 - 0.49 10.7 10.4 2.6 8.3 0.2 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1761) DUF4834 PF16118.5 ACT03496.1 - 1 10.4 0.0 1 10.4 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) FeoB_associated PF12669.7 ACT03496.1 - 2 8.9 0.0 2 8.9 0.0 3.5 4 1 0 4 4 4 0 FeoB-associated Cys-rich membrane protein DUF1980 PF09323.10 ACT03497.1 - 4.3e-20 72.4 0.5 6.3e-19 68.6 0.5 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1980) CbtA PF09490.10 ACT03497.1 - 0.079 12.7 0.2 0.079 12.7 0.2 1.7 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) FAM176 PF14851.6 ACT03497.1 - 0.19 11.4 0.0 0.22 11.1 0.0 1.1 1 0 0 1 1 1 0 FAM176 family SelP_N PF04592.14 ACT03497.1 - 1 8.7 13.4 1.5 8.2 13.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region MCPsignal PF00015.21 ACT03499.1 - 3.1e-39 134.5 45.1 3.5e-36 124.6 21.9 4.3 1 1 5 6 6 6 5 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 ACT03499.1 - 7.5e-08 32.6 3.2 3.2e-07 30.6 0.0 3.6 4 0 0 4 4 4 1 HAMP domain DUF948 PF06103.11 ACT03499.1 - 9.8e-06 25.7 32.2 0.095 13.0 2.1 6.4 3 2 3 6 6 6 4 Bacterial protein of unknown function (DUF948) Sec34 PF04136.15 ACT03499.1 - 1.3e-05 25.1 15.6 0.091 12.6 0.7 4.4 2 1 2 4 4 4 3 Sec34-like family Syntaxin-6_N PF09177.11 ACT03499.1 - 0.00088 19.8 0.5 0.00088 19.8 0.5 4.0 3 1 1 4 4 4 1 Syntaxin 6, N-terminal DUF1664 PF07889.12 ACT03499.1 - 0.015 15.3 3.4 0.015 15.3 3.4 4.7 3 2 2 5 5 5 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 ACT03499.1 - 0.019 15.1 26.7 0.56 10.4 2.9 4.3 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family NAGLU_C PF12972.7 ACT03499.1 - 0.021 14.4 0.3 0.063 12.8 0.2 1.8 1 1 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain IFT20 PF14931.6 ACT03499.1 - 0.026 14.7 21.0 0.057 13.6 0.4 3.3 3 1 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 DUF3739 PF12545.8 ACT03499.1 - 0.053 14.0 1.1 0.053 14.0 1.1 1.8 2 0 0 2 2 1 0 Filamentous haemagglutinin family outer membrane protein Ribonuc_2-5A PF06479.12 ACT03499.1 - 0.056 13.6 0.2 0.25 11.5 0.0 2.1 2 0 0 2 2 2 0 Ribonuclease 2-5A BLOC1_2 PF10046.9 ACT03499.1 - 0.056 13.7 27.9 0.16 12.3 4.5 4.3 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 ACT03499.1 - 0.058 13.4 30.7 1.8 8.6 3.0 4.8 2 2 2 4 4 4 0 Laminin Domain II SPATA6 PF14909.6 ACT03499.1 - 0.074 13.2 0.3 3.4 7.8 0.1 2.5 2 0 0 2 2 2 0 Spermatogenesis-assoc protein 6 Hormone_1 PF00103.20 ACT03499.1 - 0.46 10.2 10.8 2.4 7.9 0.8 2.8 2 2 0 2 2 2 0 Somatotropin hormone family CK2S PF15011.6 ACT03499.1 - 0.66 9.8 8.7 2.3 8.1 3.5 2.9 2 1 1 3 3 3 0 Casein Kinase 2 substrate RUN PF02759.19 ACT03499.1 - 1 9.3 5.2 1.3e+02 2.5 4.8 3.4 1 1 0 1 1 1 0 RUN domain DUF3450 PF11932.8 ACT03499.1 - 1.1 8.5 24.4 0.64 9.3 1.7 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3450) LOH1CR12 PF10158.9 ACT03499.1 - 1.8 8.6 17.8 0.11 12.5 0.3 3.8 2 1 2 4 4 4 0 Tumour suppressor protein WXG100 PF06013.12 ACT03499.1 - 4.8 7.5 22.6 2.4 8.4 0.9 6.2 5 2 2 7 7 7 0 Proteins of 100 residues with WXG Csm2_III-A PF03750.13 ACT03499.1 - 6.4 7.6 8.1 13 6.7 0.1 3.3 2 1 1 3 3 3 0 Csm2 Type III-A UPF0242 PF06785.11 ACT03499.1 - 6.6 6.8 15.8 4.7 7.3 0.6 3.1 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 ACT03499.1 - 8.7 4.1 22.3 43 1.8 22.3 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0449 PF15136.6 ACT03499.1 - 9.1 6.8 11.5 50 4.4 0.1 4.1 2 2 1 4 4 4 0 Uncharacterised protein family UPF0449 Polysacc_deac_1 PF01522.21 ACT03500.1 - 8.2e-31 106.5 0.0 1.2e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ACT03500.1 - 0.0019 17.5 0.0 0.0054 16.0 0.0 1.7 1 1 1 2 2 2 1 Glycosyl hydrolase family 57 DUF2198 PF09964.9 ACT03500.1 - 0.016 15.3 0.2 0.045 13.8 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) 3D PF06725.11 ACT03501.1 - 4.2e-18 65.3 0.9 2.8e-17 62.7 0.2 2.3 2 0 0 2 2 2 1 3D domain LysM PF01476.20 ACT03501.1 - 6.2e-12 45.4 0.1 2e-11 43.8 0.0 1.9 2 0 0 2 2 2 1 LysM domain CAP PF00188.26 ACT03502.1 - 5.3e-20 72.5 1.1 5.3e-20 72.5 1.1 1.7 2 0 0 2 2 2 1 Cysteine-rich secretory protein family DUF908 PF06012.12 ACT03502.1 - 0.67 9.3 4.1 0.9 8.9 4.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Pol_alpha_B_N PF08418.10 ACT03502.1 - 2.5 8.0 7.3 3.2 7.6 7.3 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Hamartin PF04388.12 ACT03502.1 - 4.7 5.8 8.8 5.1 5.6 8.8 1.1 1 0 0 1 1 1 0 Hamartin protein GFO_IDH_MocA PF01408.22 ACT03503.1 - 2e-30 106.1 2.6 3.2e-30 105.4 2.6 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03503.1 - 5.2e-08 32.9 0.0 1.6e-07 31.4 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACT03503.1 - 0.0033 18.1 1.0 0.0049 17.5 0.4 1.6 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ACT03503.1 - 0.032 14.5 0.7 0.13 12.5 0.7 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AP_endonuc_2 PF01261.24 ACT03504.1 - 2e-19 69.9 0.4 2.6e-19 69.5 0.4 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel UxuA PF03786.13 ACT03504.1 - 0.011 14.7 0.0 0.022 13.6 0.0 1.5 1 0 0 1 1 1 0 D-mannonate dehydratase (UxuA) TetR_C_10 PF16295.5 ACT03505.1 - 0.11 12.7 0.0 0.12 12.7 0.0 1.1 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Lipid_bd PF12888.7 ACT03506.1 - 0.032 14.7 0.6 0.06 13.8 0.6 1.4 1 0 0 1 1 1 0 Lipid-binding putative hydrolase LPAM_2 PF13627.6 ACT03506.1 - 0.067 13.1 0.4 0.1 12.5 0.4 1.3 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Pyr_redox_2 PF07992.14 ACT03507.1 - 5.7e-60 203.0 1.0 9.7e-60 202.3 0.4 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DrsE_2 PF13686.6 ACT03507.1 - 2e-59 199.9 2.5 2.5e-59 199.6 1.2 1.8 2 0 0 2 2 2 1 DsrE/DsrF/DrsH-like family Pyr_redox PF00070.27 ACT03507.1 - 1.3e-22 80.1 4.4 2.4e-20 72.9 0.1 3.9 4 0 0 4 4 3 1 Pyridine nucleotide-disulphide oxidoreductase TusA PF01206.17 ACT03507.1 - 4.6e-17 61.6 0.1 2.1e-16 59.5 0.0 2.2 2 0 0 2 2 2 1 Sulfurtransferase TusA Pyr_redox_3 PF13738.6 ACT03507.1 - 5.5e-17 62.0 0.1 2.2e-15 56.7 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rhodanese PF00581.20 ACT03507.1 - 1.4e-14 54.5 0.0 6e-14 52.5 0.0 2.1 2 0 0 2 2 2 1 Rhodanese-like domain Pyr_redox_dim PF02852.22 ACT03507.1 - 2.1e-11 44.0 0.1 2.5e-10 40.6 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain DrsE PF02635.15 ACT03507.1 - 3.8e-09 36.9 0.1 1.1e-07 32.2 0.1 2.5 1 1 0 1 1 1 1 DsrE/DsrF-like family NAD_binding_8 PF13450.6 ACT03507.1 - 1.9e-07 31.2 0.4 0.0099 16.1 0.1 3.2 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ACT03507.1 - 8.1e-06 25.7 3.9 0.34 10.5 0.0 4.1 3 1 1 4 4 4 2 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 ACT03507.1 - 0.00061 20.2 0.1 0.032 14.7 0.0 2.7 2 0 0 2 2 2 1 Putative NAD(P)-binding Lycopene_cycl PF05834.12 ACT03507.1 - 0.0014 17.8 1.2 0.02 14.0 0.1 2.8 2 1 1 3 3 3 1 Lycopene cyclase protein HI0933_like PF03486.14 ACT03507.1 - 0.0045 15.8 4.4 1.6 7.3 0.1 3.5 3 1 1 4 4 4 2 HI0933-like protein 3HCDH_N PF02737.18 ACT03507.1 - 0.0073 16.2 0.2 0.016 15.1 0.2 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ACT03507.1 - 0.011 15.0 2.3 0.075 12.3 0.3 2.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 ACT03507.1 - 0.026 13.6 2.0 0.37 9.8 0.1 2.8 2 1 1 3 3 3 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 ACT03507.1 - 0.028 14.4 3.8 42 4.1 0.1 4.3 3 1 1 4 4 4 0 FAD-NAD(P)-binding TrkA_N PF02254.18 ACT03507.1 - 0.072 13.4 0.4 0.93 9.8 0.1 2.5 2 0 0 2 2 2 0 TrkA-N domain Amino_oxidase PF01593.24 ACT03507.1 - 0.18 11.0 0.0 1.3 8.2 0.0 2.3 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 ACT03507.1 - 0.21 10.6 1.8 6.1 5.8 0.0 3.2 3 0 0 3 3 3 0 FAD binding domain FAD_binding_3 PF01494.19 ACT03507.1 - 0.27 10.5 1.3 6.1 6.0 0.2 2.9 2 1 1 3 3 3 0 FAD binding domain HTH_20 PF12840.7 ACT03508.1 - 1.3e-12 47.6 0.1 2.5e-12 46.7 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 ACT03508.1 - 5.2e-09 35.8 0.1 9.2e-09 35.0 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family TrmB PF01978.19 ACT03508.1 - 7.3e-06 25.8 0.0 1.3e-05 24.9 0.0 1.4 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 ACT03508.1 - 0.00035 20.4 0.0 0.00048 20.0 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.6 ACT03508.1 - 0.00051 20.2 0.0 0.00074 19.6 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain Rrf2 PF02082.20 ACT03508.1 - 0.0025 18.1 0.0 0.0029 17.9 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator HTH_24 PF13412.6 ACT03508.1 - 0.005 16.4 0.0 0.0096 15.5 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Fe_dep_repress PF01325.19 ACT03508.1 - 0.0059 16.8 0.0 0.016 15.4 0.0 1.7 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain BLACT_WH PF17778.1 ACT03508.1 - 0.0064 16.5 0.1 0.067 13.2 0.0 2.1 2 0 0 2 2 2 1 Beta-lactamase associated winged helix domain MarR PF01047.22 ACT03508.1 - 0.015 15.2 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_Crp_2 PF13545.6 ACT03508.1 - 0.015 15.2 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_IclR PF09339.10 ACT03508.1 - 0.04 13.7 0.1 0.072 12.9 0.0 1.6 2 0 0 2 2 2 0 IclR helix-turn-helix domain RP-C PF03428.13 ACT03508.1 - 0.13 11.9 0.0 0.28 10.8 0.0 1.4 1 1 0 1 1 1 0 Replication protein C N-terminal domain MFS_1 PF07690.16 ACT03509.1 - 2.9e-23 82.4 44.4 1.9e-13 50.1 19.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ACT03509.1 - 0.0003 19.8 11.8 0.00033 19.6 4.9 2.3 1 1 0 2 2 2 2 MFS_1 like family DUF1772 PF08592.11 ACT03510.1 - 0.074 13.4 1.1 0.092 13.1 1.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) HTH_18 PF12833.7 ACT03512.1 - 1.5e-20 73.2 0.1 2.4e-20 72.5 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03512.1 - 1.4e-12 47.4 0.2 4.7e-05 23.4 0.1 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03512.1 - 9e-11 41.8 0.4 1.6e-10 41.0 0.4 1.5 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT03512.1 - 0.0035 17.0 0.0 0.0061 16.3 0.0 1.3 1 0 0 1 1 1 1 Cupin domain UPF0122 PF04297.14 ACT03512.1 - 0.018 15.2 0.4 0.033 14.4 0.4 1.4 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like AstB PF04996.12 ACT03512.1 - 0.13 10.8 0.0 0.18 10.4 0.0 1.1 1 0 0 1 1 1 0 Succinylarginine dihydrolase Protein_K PF12283.8 ACT03512.1 - 0.24 11.6 1.5 0.45 10.8 0.1 2.0 2 0 0 2 2 2 0 Bacteriophage protein K TetR_C_33 PF13305.6 ACT03513.1 - 2.2e-19 70.1 0.0 3.2e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 ACT03513.1 - 0.00025 20.7 0.0 0.00051 19.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family Lactamase_B PF00753.27 ACT03514.1 - 1.2e-27 97.2 0.0 1.5e-27 96.9 0.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ACT03514.1 - 4.3e-07 29.6 0.0 6.4e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 ACT03514.1 - 0.005 16.3 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Acetyltransf_10 PF13673.7 ACT03516.1 - 6.9e-13 48.6 0.0 8.5e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT03516.1 - 1.7e-11 44.3 0.0 2.2e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT03516.1 - 6.5e-11 42.5 0.0 1.1e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT03516.1 - 1.5e-05 24.9 0.0 2.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_13 PF13880.6 ACT03516.1 - 0.0029 17.6 0.0 0.0049 16.8 0.0 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase DUF4303 PF14136.6 ACT03517.1 - 0.013 15.3 1.3 0.074 12.8 1.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4303) ETRAMP PF09716.10 ACT03517.1 - 0.063 13.4 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) IMP_cyclohyd PF07826.11 ACT03518.1 - 1e-55 188.3 0.0 1.2e-55 188.1 0.0 1.0 1 0 0 1 1 1 1 IMP cyclohydrolase-like protein APH PF01636.23 ACT03520.1 - 1.5e-22 80.7 0.0 2e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ACT03520.1 - 1.4e-06 28.1 0.2 3.1e-06 26.9 0.1 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.22 ACT03520.1 - 0.018 14.6 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family EcKinase PF02958.20 ACT03520.1 - 0.1 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase NUDIX PF00293.28 ACT03521.1 - 5.1e-12 46.0 0.0 6.3e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain HAD_2 PF13419.6 ACT03522.1 - 5.8e-32 111.2 0.0 7.1e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ACT03522.1 - 3.1e-13 50.5 0.1 1e-11 45.5 0.0 2.1 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT03522.1 - 3.5e-05 24.3 0.0 4.3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT03522.1 - 0.06 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Band_7 PF01145.25 ACT03523.1 - 8.7e-32 110.5 2.8 8.7e-32 110.5 2.8 2.3 2 1 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 ACT03523.1 - 0.0021 17.8 0.1 0.0048 16.6 0.1 1.7 1 0 0 1 1 1 1 SPFH domain-Band 7 family MIase PF02426.16 ACT03523.1 - 3.2 8.0 7.2 7 6.9 1.2 2.6 1 1 1 2 2 2 0 Muconolactone delta-isomerase NfeD PF01957.18 ACT03524.1 - 1.1e-16 60.9 2.0 1.1e-16 60.9 2.0 1.5 2 0 0 2 2 2 1 NfeD-like C-terminal, partner-binding IL1 PF00340.19 ACT03526.1 - 0.021 14.5 0.2 0.045 13.4 0.0 1.6 2 0 0 2 2 2 0 Interleukin-1 / 18 Thioredoxin PF00085.20 ACT03526.1 - 0.11 12.5 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Cation_efflux PF01545.21 ACT03527.1 - 0.00032 20.5 0.1 0.00044 20.0 0.1 1.2 1 0 0 1 1 1 1 Cation efflux family Saf_2TM PF18303.1 ACT03527.1 - 0.12 11.9 0.1 0.27 10.8 0.0 1.6 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Acetyltransf_10 PF13673.7 ACT03528.1 - 2.1e-12 47.1 0.0 2.7e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT03528.1 - 7.2e-09 36.0 0.0 8.6e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT03528.1 - 1.5e-06 28.5 0.0 1.9e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ACT03528.1 - 0.057 13.4 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein NUDIX PF00293.28 ACT03529.1 - 8.2e-14 51.8 0.0 1e-13 51.4 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 ACT03529.1 - 0.03 13.9 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 Nucleotide hydrolase HEAT_2 PF13646.6 ACT03531.1 - 4.1e-12 46.3 0.2 1.9e-05 25.0 0.0 2.4 1 1 2 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 ACT03531.1 - 0.00011 22.5 0.4 0.0035 17.9 0.0 3.2 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat DUF1157 PF06636.11 ACT03531.1 - 0.052 12.4 0.9 0.077 11.8 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1157) Arm PF00514.23 ACT03531.1 - 0.098 12.7 0.0 55 4.0 0.0 3.4 2 1 1 3 3 3 0 Armadillo/beta-catenin-like repeat Ank_3 PF13606.6 ACT03531.1 - 0.2 12.3 1.4 26 5.8 0.0 3.6 3 1 1 4 4 4 0 Ankyrin repeat Clathrin PF00637.20 ACT03531.1 - 0.39 10.6 4.7 0.23 11.3 0.8 2.2 2 1 0 2 2 2 0 Region in Clathrin and VPS AAA_18 PF13238.6 ACT03533.1 - 4.6e-05 24.0 0.0 0.00011 22.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ACT03533.1 - 0.016 15.5 0.0 0.031 14.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ACT03533.1 - 0.035 14.3 0.0 0.1 12.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain Amidase PF01425.21 ACT03535.1 - 5e-71 240.0 0.0 7.3e-71 239.5 0.0 1.2 1 0 0 1 1 1 1 Amidase DUF2020 PF09449.10 ACT03535.1 - 0.14 12.0 0.1 0.29 11.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2020) PucR PF07905.11 ACT03536.1 - 3.9e-35 120.7 0.0 3.8e-34 117.5 0.0 2.4 2 0 0 2 2 2 1 Purine catabolism regulatory protein-like family HTH_30 PF13556.6 ACT03536.1 - 1.1e-19 69.9 0.1 3e-19 68.6 0.1 1.8 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain GGDEF_2 PF17853.1 ACT03536.1 - 2.1e-09 37.6 1.1 6.7e-09 36.0 0.3 2.3 3 0 0 3 3 3 1 GGDEF-like domain DUF2089 PF09862.9 ACT03536.1 - 0.016 15.2 0.1 0.075 13.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2089) Cupin_2 PF07883.11 ACT03537.1 - 4.2e-14 52.0 0.1 7.5e-14 51.2 0.1 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ACT03537.1 - 5.9e-11 42.2 0.0 7.2e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 ACT03537.1 - 4.5e-08 33.1 0.1 1.5e-07 31.4 0.0 1.7 2 0 0 2 2 2 1 AraC-like ligand binding domain Ppnp PF06865.11 ACT03537.1 - 0.0058 17.0 0.0 0.018 15.4 0.0 1.8 2 0 0 2 2 2 1 Pyrimidine/purine nucleoside phosphorylase Cupin_3 PF05899.12 ACT03537.1 - 0.017 14.8 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) CENP-C_C PF11699.8 ACT03537.1 - 0.096 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Mif2/CENP-C like Amido_AtzD_TrzD PF09663.10 ACT03538.1 - 3.8e-160 532.8 1.4 4.4e-160 532.6 1.4 1.0 1 0 0 1 1 1 1 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD) BPD_transp_1 PF00528.22 ACT03539.1 - 5.8e-24 84.8 9.5 5.8e-24 84.8 9.5 1.4 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 ACT03540.1 - 1.7e-30 106.3 0.0 3e-30 105.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT03540.1 - 5.6e-07 29.7 0.7 0.011 15.5 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ACT03540.1 - 2.4e-06 28.0 0.0 3.6e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT03540.1 - 3.8e-05 24.0 0.0 0.00011 22.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT03540.1 - 0.00029 20.5 0.0 0.00067 19.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT03540.1 - 0.0013 18.6 0.1 0.0022 17.9 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA PF00004.29 ACT03540.1 - 0.0019 18.6 0.0 0.0083 16.6 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ACT03540.1 - 0.003 17.5 0.0 0.0063 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 ACT03540.1 - 0.0037 17.2 0.0 0.017 15.0 0.0 1.9 2 1 0 2 2 2 1 Rad17 P-loop domain ATPase_2 PF01637.18 ACT03540.1 - 0.0049 16.8 0.0 0.034 14.0 0.0 1.9 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea SMC_N PF02463.19 ACT03540.1 - 0.011 15.2 0.2 0.64 9.4 0.0 2.2 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 ACT03540.1 - 0.022 14.1 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_23 PF13476.6 ACT03540.1 - 0.029 14.9 0.0 0.049 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Adeno_IVa2 PF02456.15 ACT03540.1 - 0.031 13.1 0.0 0.047 12.5 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein PRK PF00485.18 ACT03540.1 - 0.06 13.1 0.0 0.21 11.3 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 ACT03540.1 - 0.079 13.4 0.1 0.33 11.3 0.0 1.9 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.22 ACT03540.1 - 0.1 11.7 0.0 0.21 10.7 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 ACT03540.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 ACT03540.1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ACT03540.1 - 0.16 12.1 0.0 0.21 11.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 ACT03540.1 - 0.16 12.0 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 ACT03540.1 - 0.17 12.0 0.1 0.42 10.7 0.1 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_14 PF13173.6 ACT03540.1 - 0.17 11.9 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ACT03540.1 - 0.18 11.5 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain NMT1 PF09084.11 ACT03541.1 - 2.2e-62 210.8 0.4 2.9e-62 210.4 0.4 1.2 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_3 PF16868.5 ACT03541.1 - 0.00022 20.8 0.0 0.00029 20.4 0.0 1.2 1 0 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.20 ACT03541.1 - 0.00053 19.5 0.0 0.00076 19.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Phosphonate-bd PF12974.7 ACT03541.1 - 0.0093 15.6 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1_2 PF13379.6 ACT03541.1 - 0.033 13.9 0.1 0.078 12.7 0.1 1.6 1 1 0 1 1 1 0 NMT1-like family Isochorismatase PF00857.20 ACT03542.1 - 1.9e-42 145.4 0.0 4.5e-42 144.2 0.0 1.6 1 1 0 1 1 1 1 Isochorismatase family Acetyltransf_1 PF00583.25 ACT03543.1 - 1.9e-18 66.8 0.3 4.1e-14 52.8 0.1 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT03543.1 - 2.3e-16 60.0 0.4 3.1e-12 46.8 0.1 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT03543.1 - 2.4e-13 50.1 0.0 2.5e-10 40.4 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACT03543.1 - 2e-11 44.7 0.1 2.9e-07 31.2 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT03543.1 - 6e-10 39.0 0.1 1.7e-07 31.1 0.0 3.5 3 1 1 4 4 4 1 FR47-like protein Acetyltransf_9 PF13527.7 ACT03543.1 - 3.3e-08 33.7 0.2 0.015 15.4 0.0 2.9 3 1 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACT03543.1 - 0.00099 19.2 0.0 0.38 10.9 0.0 2.6 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.6 ACT03543.1 - 0.0032 17.1 0.0 0.006 16.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ACT03543.1 - 0.0049 16.4 0.0 0.013 15.0 0.0 1.7 2 0 0 2 2 2 1 Putative acetyl-transferase Acetyltransf_4 PF13420.7 ACT03543.1 - 0.012 15.8 0.1 0.12 12.5 0.1 2.6 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_18 PF18014.1 ACT03543.1 - 0.025 14.4 0.0 4.3 7.2 0.0 2.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Sec23_BS PF08033.12 ACT03543.1 - 0.11 13.3 0.0 0.33 11.7 0.0 1.8 2 0 0 2 2 1 0 Sec23/Sec24 beta-sandwich domain SUKH_6 PF14568.6 ACT03544.1 - 0.025 15.0 0.0 0.025 15.0 0.0 1.2 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall RF3_C PF16658.5 ACT03544.1 - 0.037 13.8 0.0 0.038 13.8 0.0 1.1 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain Abhydrolase_1 PF00561.20 ACT03545.1 - 1.5e-30 106.7 0.1 4.6e-24 85.4 0.1 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACT03545.1 - 4.6e-23 83.0 0.1 5.3e-23 82.8 0.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACT03545.1 - 1.7e-22 79.8 0.0 9.1e-16 57.8 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF1057 PF06342.12 ACT03545.1 - 5.9e-10 38.6 0.0 7.6e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Ndr PF03096.14 ACT03545.1 - 1.2e-07 30.8 0.0 5.8e-07 28.5 0.0 1.8 2 0 0 2 2 2 1 Ndr family DUF3530 PF12048.8 ACT03545.1 - 1.8e-06 27.6 0.0 3.1e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3530) Abhydrolase_4 PF08386.10 ACT03545.1 - 1.1e-05 25.4 0.0 2.4e-05 24.4 0.0 1.5 2 0 0 2 2 1 1 TAP-like protein Abhydrolase_5 PF12695.7 ACT03545.1 - 2.1e-05 24.3 0.0 0.0087 15.8 0.0 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family FSH1 PF03959.13 ACT03545.1 - 8.7e-05 22.3 0.0 0.0073 16.0 0.1 2.8 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 ACT03545.1 - 0.00015 21.3 0.1 0.0022 17.5 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Thioesterase PF00975.20 ACT03545.1 - 0.00038 20.7 0.0 0.00056 20.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 ACT03545.1 - 0.00099 19.0 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF915 PF06028.11 ACT03545.1 - 0.0019 17.6 0.0 0.0037 16.6 0.0 1.5 2 0 0 2 2 1 1 Alpha/beta hydrolase of unknown function (DUF915) Chlorophyllase PF07224.11 ACT03545.1 - 0.0026 16.8 0.0 0.32 9.9 0.0 2.1 2 0 0 2 2 2 1 Chlorophyllase Chlorophyllase2 PF12740.7 ACT03545.1 - 0.0041 16.1 0.0 0.01 14.7 0.0 1.6 1 1 0 1 1 1 1 Chlorophyllase enzyme LIP PF03583.14 ACT03545.1 - 0.0049 16.2 0.0 0.0063 15.9 0.0 1.3 1 0 0 1 1 1 1 Secretory lipase Ser_hydrolase PF06821.13 ACT03545.1 - 0.0069 16.3 0.0 0.69 9.8 0.0 2.3 2 1 0 2 2 2 1 Serine hydrolase DLH PF01738.18 ACT03545.1 - 0.0084 15.7 0.0 0.4 10.2 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family DUF1749 PF08538.10 ACT03545.1 - 0.01 14.9 0.0 0.015 14.4 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1749) Abhydrolase_3 PF07859.13 ACT03545.1 - 0.014 15.3 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Palm_thioest PF02089.15 ACT03545.1 - 0.03 14.2 0.0 0.076 12.8 0.0 1.7 2 0 0 2 2 2 0 Palmitoyl protein thioesterase Abhydrolase_2 PF02230.16 ACT03545.1 - 0.048 13.5 0.0 9.3 6.0 0.0 3.0 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase PGAP1 PF07819.13 ACT03545.1 - 0.052 13.3 0.0 0.11 12.2 0.0 1.6 2 0 0 2 2 1 0 PGAP1-like protein LIDHydrolase PF10230.9 ACT03545.1 - 0.063 12.8 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF2974 PF11187.8 ACT03545.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Peptidase_S15 PF02129.18 ACT03545.1 - 0.17 11.4 0.0 1.5 8.3 0.0 2.0 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) OsmC PF02566.19 ACT03546.1 - 1.9e-14 53.9 0.0 2.8e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 OsmC-like protein APH PF01636.23 ACT03547.1 - 9.6e-25 87.9 0.0 1.3e-24 87.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ACT03547.1 - 3.8e-06 26.4 0.1 5.9e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 ACT03547.1 - 5.4e-06 25.5 0.0 7.4e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Fructosamin_kin PF03881.14 ACT03547.1 - 0.0014 17.9 0.1 0.002 17.4 0.1 1.4 1 1 0 1 1 1 1 Fructosamine kinase Choline_kinase PF01633.20 ACT03547.1 - 0.033 13.8 0.2 0.054 13.1 0.2 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Dioxygenase_N PF04444.14 ACT03547.1 - 0.04 13.8 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 Catechol dioxygenase N terminus Pkinase PF00069.25 ACT03547.1 - 0.056 12.8 0.1 0.09 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein kinase domain ISP1_C PF18161.1 ACT03549.1 - 0.041 13.9 0.1 0.075 13.0 0.0 1.6 2 0 0 2 2 2 0 ISP1 C-terminal DUF5042 PF16445.5 ACT03549.1 - 0.055 11.9 0.0 0.074 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5042) Cu_amine_oxidN1 PF07833.11 ACT03551.1 - 2e-05 25.0 0.5 0.00024 21.5 0.5 2.6 1 1 1 2 2 2 1 Copper amine oxidase N-terminal domain Acetyltransf_7 PF13508.7 ACT03552.1 - 1.6e-12 47.7 0.1 8.8e-12 45.3 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT03552.1 - 2.1e-10 40.9 0.1 6.2e-10 39.3 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT03552.1 - 4.7e-09 36.3 0.0 8.1e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT03552.1 - 1.6e-06 28.2 0.1 0.00032 20.8 0.0 3.0 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT03552.1 - 0.00074 19.4 0.0 0.0017 18.3 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 ACT03552.1 - 0.0013 18.2 0.0 0.0023 17.4 0.0 1.5 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_13 PF13880.6 ACT03552.1 - 0.035 14.1 0.0 0.061 13.3 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_CG PF14542.6 ACT03552.1 - 0.053 13.7 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF4440 PF14534.6 ACT03553.1 - 0.0058 17.0 0.1 0.01 16.2 0.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 ACT03553.1 - 0.0072 16.9 0.1 0.014 16.0 0.1 1.6 1 1 0 1 1 1 1 SnoaL-like domain Pes-10 PF07149.11 ACT03554.1 - 0.034 13.2 0.0 0.043 12.9 0.0 1.1 1 0 0 1 1 1 0 Pes-10 Glu-tRNAGln PF02686.15 ACT03554.1 - 0.043 14.1 0.1 0.15 12.4 0.1 1.9 1 1 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit Alpha_L_fucos PF01120.17 ACT03555.1 - 6.6e-41 140.9 5.4 8.9e-41 140.5 5.4 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL6 PF14871.6 ACT03555.1 - 0.00017 21.7 0.5 0.0005 20.2 0.1 2.1 3 1 0 3 3 3 1 Hypothetical glycosyl hydrolase 6 DUF1554 PF07588.11 ACT03555.1 - 0.0047 16.7 1.9 0.12 12.1 0.5 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1554) HTH_18 PF12833.7 ACT03556.1 - 3.1e-19 69.0 0.2 6.1e-19 68.1 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03556.1 - 1.2e-11 44.3 1.9 3.9e-05 23.6 0.1 2.9 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03556.1 - 5.5e-08 32.8 0.5 1.4e-07 31.5 0.1 1.8 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT03556.1 - 0.0072 16.0 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Cupin domain ROS_MUCR PF05443.11 ACT03556.1 - 0.27 11.3 3.6 6.6 6.8 0.2 2.3 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein HTH_18 PF12833.7 ACT03557.1 - 9.5e-24 83.5 0.3 1.8e-23 82.6 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03557.1 - 4e-15 55.5 0.1 2.8e-07 30.4 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03557.1 - 1e-11 44.9 0.4 1.9e-11 44.0 0.4 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT03557.1 - 0.0025 17.5 0.1 0.0043 16.7 0.1 1.3 1 0 0 1 1 1 1 Cupin domain MarR_2 PF12802.7 ACT03557.1 - 0.0077 16.1 0.0 0.32 10.9 0.0 3.0 3 1 0 3 3 3 1 MarR family Plavaka PF18759.1 ACT03557.1 - 0.036 13.3 0.0 0.047 12.9 0.0 1.2 1 0 0 1 1 1 0 Plavaka transposase AP_endonuc_2 PF01261.24 ACT03558.1 - 6.8e-22 77.9 0.0 9.8e-22 77.4 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel AP_endonuc_2_N PF07582.12 ACT03558.1 - 0.015 15.0 0.0 0.037 13.7 0.0 1.7 1 0 0 1 1 1 0 AP endonuclease family 2 C terminus GFO_IDH_MocA PF01408.22 ACT03559.1 - 1.7e-07 32.1 0.0 3e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03559.1 - 2e-06 27.8 0.0 3.9e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.22 ACT03560.1 - 3.4e-20 73.1 0.0 5.8e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03560.1 - 3e-12 46.6 0.1 7.1e-12 45.4 0.1 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 ACT03560.1 - 8.4e-06 26.3 0.0 2.1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ACT03560.1 - 0.00029 21.0 0.0 0.00044 20.4 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 ACT03560.1 - 0.017 15.3 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 ACT03560.1 - 0.073 12.9 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 ACT03560.1 - 0.08 13.6 0.0 0.2 12.3 0.0 1.6 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain DUF2423 PF10338.9 ACT03560.1 - 0.48 10.7 0.0 0.48 10.7 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2423) RepB_primase PF16793.5 ACT03561.1 - 3.1e-08 34.1 0.0 1.5e-07 31.8 0.0 1.8 1 1 1 2 2 2 1 RepB DNA-primase from phage plasmid RB_A PF01858.17 ACT03561.1 - 0.0074 16.1 1.1 0.012 15.5 1.1 1.3 1 0 0 1 1 1 1 Retinoblastoma-associated protein A domain pPIWI_RE_Z PF18155.1 ACT03561.1 - 0.033 14.1 0.3 0.066 13.1 0.2 1.5 2 0 0 2 2 2 0 pPIWI RE three-gene island domain Z Rotamase_3 PF13616.6 ACT03561.1 - 0.19 12.3 2.0 5.5 7.6 2.0 2.3 1 1 0 1 1 1 0 PPIC-type PPIASE domain Amidase_2 PF01510.25 ACT03562.1 - 1.4e-20 74.1 0.3 1.7e-19 70.5 0.2 2.0 2 0 0 2 2 2 1 N-acetylmuramoyl-L-alanine amidase FliT PF05400.13 ACT03562.1 - 0.063 14.1 0.5 0.53 11.1 0.1 2.0 2 0 0 2 2 2 0 Flagellar protein FliT SLH PF00395.20 ACT03562.1 - 0.16 12.0 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 S-layer homology domain Flavodoxin_2 PF02525.17 ACT03564.1 - 6.5e-41 140.2 0.0 7.4e-41 140.0 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ACT03564.1 - 2.3e-06 27.4 0.0 2.8e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_4 PF12682.7 ACT03564.1 - 0.0034 17.1 0.0 0.0047 16.6 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin PEP_hydrolase PF09370.10 ACT03564.1 - 0.047 12.9 0.0 0.081 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like Response_reg PF00072.24 ACT03565.1 - 1.5e-28 99.2 0.2 4.1e-28 97.8 0.3 1.6 2 0 0 2 2 2 1 Response regulator receiver domain GerE PF00196.19 ACT03565.1 - 4.1e-20 71.1 0.1 6.6e-20 70.4 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACT03565.1 - 6.5e-07 28.9 0.2 1.2e-06 28.1 0.2 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_40 PF14493.6 ACT03565.1 - 0.0017 18.8 0.3 0.014 15.9 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain Sigma70_r4 PF04545.16 ACT03565.1 - 0.0023 17.4 0.1 0.0047 16.4 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_24 PF13412.6 ACT03565.1 - 0.055 13.0 0.3 0.13 11.9 0.1 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Sigma70_ECF PF07638.11 ACT03565.1 - 0.074 12.9 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 ECF sigma factor HTH_38 PF13936.6 ACT03565.1 - 0.18 11.6 0.0 0.49 10.2 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_10 PF04967.12 ACT03565.1 - 0.74 9.7 2.5 1.9 8.4 0.1 2.4 3 0 0 3 3 3 0 HTH DNA binding domain GAF_2 PF13185.6 ACT03566.1 - 6.3e-23 81.6 0.1 2.8e-11 43.8 0.0 2.8 3 0 0 3 3 3 2 GAF domain GAF_3 PF13492.6 ACT03566.1 - 2e-21 76.7 0.0 3.2e-09 37.2 0.0 3.2 3 1 0 3 3 3 2 GAF domain HisKA_3 PF07730.13 ACT03566.1 - 6.4e-18 65.0 1.1 1.6e-17 63.8 0.2 2.2 2 0 0 2 2 2 1 Histidine kinase GAF PF01590.26 ACT03566.1 - 8e-14 52.4 0.1 3.4e-07 30.9 0.1 2.5 2 0 0 2 2 2 2 GAF domain HATPase_c PF02518.26 ACT03566.1 - 0.00023 21.7 0.1 0.00074 20.0 0.1 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT03566.1 - 0.063 13.2 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Autoind_bind PF03472.15 ACT03566.1 - 0.073 12.5 0.0 12 5.4 0.0 2.9 2 1 0 2 2 2 0 Autoinducer binding domain RlaP PF10127.9 ACT03567.1 - 1.1e-89 300.3 0.0 1.2e-89 300.1 0.0 1.0 1 0 0 1 1 1 1 RNA repair pathway DNA polymerase beta family Band_7 PF01145.25 ACT03568.1 - 5.2e-21 75.5 0.0 9.6e-17 61.6 0.1 2.8 3 0 0 3 3 3 2 SPFH domain / Band 7 family CbbQ_C PF08406.10 ACT03568.1 - 0.12 12.7 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 CbbQ/NirQ/NorQ C-terminal WYL PF13280.6 ACT03569.1 - 3.1e-33 115.3 0.1 4.4e-33 114.7 0.1 1.2 1 0 0 1 1 1 1 WYL domain HTH_DeoR PF08220.12 ACT03569.1 - 8.2e-05 22.3 0.1 0.0037 17.0 0.0 2.6 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACT03569.1 - 0.0033 17.3 0.1 0.45 10.5 0.0 2.6 2 0 0 2 2 2 1 HTH domain HTH_23 PF13384.6 ACT03569.1 - 0.015 15.1 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain HTH_20 PF12840.7 ACT03569.1 - 0.022 14.8 0.7 5 7.3 0.0 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT03569.1 - 0.048 13.6 0.4 1.2 9.1 0.0 3.2 4 0 0 4 4 4 0 Crp-like helix-turn-helix domain WYL PF13280.6 ACT03570.1 - 2.5e-11 43.9 0.4 3.5e-11 43.5 0.4 1.2 1 0 0 1 1 1 1 WYL domain DUF305 PF03713.13 ACT03570.1 - 0.073 13.2 0.4 0.17 12.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF305) EccE PF11203.8 ACT03570.1 - 0.15 12.4 0.5 4.8 7.6 0.0 3.0 2 2 1 4 4 4 0 Putative type VII ESX secretion system translocon, EccE ketoacyl-synt PF00109.26 ACT03571.1 - 1.4e-62 211.6 5.7 8.6e-62 209.0 1.8 2.1 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ACT03571.1 - 3.5e-35 120.6 0.4 5.7e-35 119.9 0.4 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 ACT03571.1 - 1.4e-05 24.6 1.1 0.00037 19.9 0.2 2.3 2 0 0 2 2 2 1 Thiolase, N-terminal domain NMT1_2 PF13379.6 ACT03571.1 - 0.0073 16.0 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 NMT1-like family KAsynt_C_assoc PF16197.5 ACT03571.1 - 0.038 14.4 0.0 0.11 12.9 0.0 1.8 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension MLTR_LBD PF17765.1 ACT03572.1 - 2.3e-40 138.5 0.0 4.6e-40 137.5 0.0 1.4 2 0 0 2 2 2 1 MmyB-like transcription regulator ligand binding domain HTH_31 PF13560.6 ACT03572.1 - 6.3e-17 61.7 1.5 1.8e-16 60.2 1.5 1.9 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 ACT03572.1 - 0.00047 20.2 0.0 0.0014 18.6 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix FAA_hydrolase PF01557.18 ACT03573.1 - 6.3e-74 248.3 0.0 7.9e-74 248.0 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Polysacc_deac_1 PF01522.21 ACT03574.1 - 8.1e-23 80.7 0.2 1.2e-22 80.1 0.2 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase RAP PF08373.10 ACT03574.1 - 0.0058 16.7 0.8 0.076 13.1 0.1 2.7 3 0 0 3 3 3 1 RAP domain Cu_amine_oxidN1 PF07833.11 ACT03575.1 - 5.6e-05 23.6 4.1 0.0016 18.9 0.0 4.3 5 1 0 5 5 5 1 Copper amine oxidase N-terminal domain DUF2850 PF11012.8 ACT03575.1 - 0.0062 16.8 0.9 3.2 8.1 0.0 3.6 4 0 0 4 4 4 1 Protein of unknown function (DUF2850) DUF1223 PF06764.11 ACT03575.1 - 0.0084 16.2 2.7 1.3 9.0 0.2 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1223) NIR_SIR_ferr PF03460.17 ACT03575.1 - 0.15 12.0 0.0 3.6 7.5 0.0 2.8 3 0 0 3 3 3 0 Nitrite/Sulfite reductase ferredoxin-like half domain Gag_spuma PF03276.14 ACT03575.1 - 0.22 9.9 0.4 0.9 7.9 0.1 2.0 2 0 0 2 2 2 0 Spumavirus gag protein DUF2922 PF11148.8 ACT03575.1 - 0.39 10.5 2.9 12 5.8 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2922) Cu_amine_oxidN1 PF07833.11 ACT03576.1 - 1.6e-08 34.9 0.1 0.00039 20.8 0.0 4.9 4 3 2 6 6 6 2 Copper amine oxidase N-terminal domain DUF2850 PF11012.8 ACT03576.1 - 2.4e-06 27.7 0.8 0.18 12.1 0.1 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF2850) PG_binding_4 PF12229.8 ACT03576.1 - 0.00019 21.7 1.6 0.94 9.8 0.0 3.8 4 0 0 4 4 4 2 Putative peptidoglycan binding domain CytoC_RC PF02276.18 ACT03576.1 - 0.0054 16.1 0.5 0.02 14.3 0.0 2.0 2 0 0 2 2 2 1 Photosynthetic reaction centre cytochrome C subunit HepII_C PF18675.1 ACT03576.1 - 0.0076 16.3 6.9 0.27 11.4 0.4 3.6 3 0 0 3 3 3 2 Heparinase II C-terminal domain Semialdhyde_dhC PF02774.18 ACT03576.1 - 0.01 15.9 0.2 0.45 10.6 0.0 2.5 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain Ribosomal_L2_C PF03947.18 ACT03576.1 - 0.11 12.7 1.5 2.3 8.4 0.1 2.4 2 0 0 2 2 2 0 Ribosomal Proteins L2, C-terminal domain DUF2922 PF11148.8 ACT03576.1 - 0.24 11.2 5.0 26 4.6 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2922) Arabino_trans_N PF17689.1 ACT03576.1 - 1.1 9.3 11.9 2.2 8.4 1.2 3.5 2 1 2 4 4 4 0 Arabinosyltransferase concanavalin like domain YbbR PF07949.12 ACT03576.1 - 3.4 8.1 7.0 34 4.8 0.9 3.7 3 0 0 3 3 3 0 YbbR-like protein PD40 PF07676.12 ACT03577.1 - 0.057 13.4 0.2 23 5.1 0.1 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat TAT_signal PF10518.9 ACT03577.1 - 0.82 9.6 4.2 0.33 10.9 1.3 1.9 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence HATPase_c PF02518.26 ACT03578.1 - 5.7e-25 88.0 0.0 1.5e-24 86.6 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT03578.1 - 4.3e-13 49.1 0.9 1.2e-12 47.7 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT03578.1 - 2.6e-06 27.7 0.2 1.6e-05 25.2 0.0 2.4 3 0 0 3 3 3 1 HAMP domain HATPase_c_2 PF13581.6 ACT03578.1 - 0.011 15.7 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 ACT03578.1 - 0.012 15.5 0.1 0.066 13.1 0.1 2.2 1 1 0 1 1 1 0 GHKL domain LXG PF04740.12 ACT03578.1 - 0.016 14.9 0.1 0.016 14.9 0.1 2.2 3 0 0 3 3 3 0 LXG domain of WXG superfamily GA PF01468.17 ACT03578.1 - 0.099 12.9 1.5 0.26 11.6 1.5 1.7 1 0 0 1 1 1 0 GA module DUF1664 PF07889.12 ACT03578.1 - 1.2 9.2 4.5 1.4 9.0 0.0 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Response_reg PF00072.24 ACT03579.1 - 6.3e-28 97.2 0.4 9e-28 96.7 0.4 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT03579.1 - 6.2e-26 90.3 0.0 1.4e-25 89.2 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal GerE PF00196.19 ACT03579.1 - 0.14 11.7 0.1 9 5.9 0.0 3.2 3 0 0 3 3 3 0 Bacterial regulatory proteins, luxR family SprT-like PF10263.9 ACT03580.1 - 2.1e-10 40.5 0.3 2.6e-10 40.1 0.3 1.2 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 ACT03580.1 - 3.9e-07 29.8 4.4 8.2e-07 28.8 4.4 1.6 1 0 0 1 1 1 1 SprT-like zinc ribbon domain zinc_ribbon_10 PF10058.9 ACT03580.1 - 0.024 14.4 0.3 0.053 13.3 0.3 1.6 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein HypA PF01155.19 ACT03580.1 - 0.087 12.8 0.9 0.13 12.3 0.9 1.4 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3697 PF12478.8 ACT03581.1 - 0.11 12.6 0.0 1.9 8.6 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-associated protein 2 Nitroreductase PF00881.24 ACT03583.1 - 3.6e-34 118.3 0.0 4.4e-34 118.0 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 ACT03583.1 - 4e-11 42.9 0.4 2.5e-05 24.0 0.0 3.6 3 1 1 4 4 4 2 Putative TM nitroreductase Sin_N PF04801.13 ACT03583.1 - 0.16 11.1 0.1 0.22 10.7 0.1 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region Rrf2 PF02082.20 ACT03584.1 - 2.2e-18 66.4 0.1 6e-18 65.0 0.0 1.7 2 0 0 2 2 2 1 Transcriptional regulator MarR PF01047.22 ACT03584.1 - 0.0042 17.0 0.5 0.018 15.0 0.1 1.9 2 0 0 2 2 2 1 MarR family DnaG_DnaB_bind PF08278.11 ACT03584.1 - 0.0054 17.3 0.3 0.24 12.0 0.0 2.1 2 0 0 2 2 2 1 DNA primase DnaG DnaB-binding HrcA_DNA-bdg PF03444.15 ACT03584.1 - 0.0066 16.1 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding GntR PF00392.21 ACT03584.1 - 0.012 15.3 0.7 0.029 14.0 0.7 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family TFIIE_alpha PF02002.17 ACT03584.1 - 0.051 13.4 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 TFIIE alpha subunit HTH_Crp_2 PF13545.6 ACT03584.1 - 0.065 13.2 0.9 0.11 12.5 0.1 1.7 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_39 PF14090.6 ACT03584.1 - 0.22 11.3 1.5 0.29 10.9 0.3 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_20 PF12840.7 ACT03584.1 - 1.2 9.2 4.5 3.4 7.8 1.0 2.6 2 1 0 2 2 2 0 Helix-turn-helix domain Tex_N PF09371.10 ACT03585.1 - 7.5e-71 237.6 2.9 1.8e-70 236.3 2.9 1.7 1 0 0 1 1 1 1 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 ACT03585.1 - 8.6e-53 178.1 0.2 2.4e-52 176.7 0.2 1.8 1 0 0 1 1 1 1 Tex protein YqgF-like domain HHH_3 PF12836.7 ACT03585.1 - 7.9e-28 96.5 0.3 3.2e-27 94.6 0.1 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_9 PF17674.1 ACT03585.1 - 1.2e-21 77.4 0.0 5.7e-21 75.2 0.0 2.3 1 0 0 1 1 1 1 HHH domain S1 PF00575.23 ACT03585.1 - 4.6e-16 58.9 0.3 9.6e-16 57.9 0.3 1.6 1 0 0 1 1 1 1 S1 RNA binding domain HHH_7 PF14635.6 ACT03585.1 - 1.3e-07 31.8 0.0 6.9e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif YqgF PF14639.6 ACT03585.1 - 4.3e-07 29.8 0.0 1.8e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 Lactamase_B PF00753.27 ACT03586.1 - 9.3e-31 107.4 0.7 1.1e-30 107.2 0.7 1.0 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ACT03586.1 - 8.7e-09 35.2 0.0 1.1e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ACT03586.1 - 0.0061 16.5 0.0 0.0089 15.9 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Thioredoxin_9 PF14595.6 ACT03587.1 - 3.7e-38 130.2 0.0 6e-38 129.5 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin YkyA PF10368.9 ACT03587.1 - 0.061 13.0 0.1 0.16 11.7 0.0 1.6 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein PhoPQ_related PF10142.9 ACT03587.1 - 0.14 10.8 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein SNARE_assoc PF09335.11 ACT03588.1 - 2.4e-21 76.4 6.4 2.4e-21 76.4 6.4 1.6 2 0 0 2 2 2 1 SNARE associated Golgi protein Cation_efflux PF01545.21 ACT03588.1 - 0.035 13.8 3.8 0.05 13.3 3.8 1.2 1 0 0 1 1 1 0 Cation efflux family DUF2938 PF11158.8 ACT03588.1 - 0.054 13.0 3.3 0.05 13.1 1.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2938) MscS_TM PF12794.7 ACT03588.1 - 0.084 11.7 0.2 0.084 11.7 0.2 1.7 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Cupredoxin_1 PF13473.6 ACT03589.1 - 6.1e-13 48.8 0.0 1.3e-12 47.8 0.0 1.4 1 1 0 1 1 1 1 Cupredoxin-like domain Cu-oxidase_2 PF07731.14 ACT03589.1 - 0.0046 16.7 0.0 1.3 8.8 0.0 2.1 2 0 0 2 2 2 2 Multicopper oxidase DUF2556 PF10831.8 ACT03589.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2556) DUF3872 PF12988.7 ACT03589.1 - 0.12 12.2 0.0 0.65 9.8 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3872) SpoIIIAH PF12685.7 ACT03589.1 - 0.14 12.0 0.0 0.15 11.9 0.0 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein CMV_US PF08001.11 ACT03589.1 - 0.14 11.4 0.2 0.19 11.0 0.2 1.1 1 0 0 1 1 1 0 CMV US SLH PF00395.20 ACT03591.1 - 8.2e-16 57.7 0.1 0.00015 21.7 0.0 3.7 3 0 0 3 3 3 3 S-layer homology domain DUF4901 PF16244.5 ACT03591.1 - 1.2e-15 57.5 0.0 1.8e-08 34.1 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4901) PepSY PF03413.19 ACT03591.1 - 5.3e-12 46.1 15.6 0.097 13.3 0.0 6.4 6 0 0 6 6 6 5 Peptidase propeptide and YPEB domain FTP PF07504.13 ACT03591.1 - 1.3e-05 24.9 4.8 0.05 13.4 0.0 2.8 2 0 0 2 2 2 2 Fungalysin/Thermolysin Propeptide Motif YPEB PF14620.6 ACT03591.1 - 0.015 14.7 1.1 0.29 10.5 0.3 2.8 2 1 0 2 2 2 0 YpeB sporulation SspH PF08141.12 ACT03592.1 - 2.9e-21 75.4 0.2 3.2e-21 75.2 0.2 1.0 1 0 0 1 1 1 1 Small acid-soluble spore protein H family Ku PF02735.16 ACT03594.1 - 1.6e-38 132.4 0.0 2.4e-38 131.9 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain DNA_ligase_A_M PF01068.21 ACT03595.1 - 1.2e-28 100.1 0.0 1.6e-28 99.8 0.0 1.1 1 0 0 1 1 1 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 ACT03595.1 - 1.5e-06 28.6 0.0 1.9e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_C PF04679.15 ACT03595.1 - 0.00083 19.9 0.0 0.0019 18.8 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region PLDc_2 PF13091.6 ACT03597.1 - 7.2e-41 139.2 0.0 1.6e-23 83.0 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ACT03597.1 - 2.5e-14 52.8 1.0 3.1e-06 27.1 0.0 2.4 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_N PF13396.6 ACT03597.1 - 0.00013 21.8 4.9 0.00013 21.8 4.9 2.0 2 0 0 2 2 2 1 Phospholipase_D-nuclease N-terminal Regulator_TrmB PF11495.8 ACT03597.1 - 0.061 12.5 0.0 0.15 11.3 0.0 1.6 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB PP_kinase_C PF13090.6 ACT03597.1 - 0.12 11.8 0.1 1.7 8.1 0.0 2.4 2 1 0 2 2 2 0 Polyphosphate kinase C-terminal domain 2 RmlD_sub_bind PF04321.17 ACT03598.1 - 2.8e-112 374.5 0.0 3.1e-112 374.4 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 ACT03598.1 - 5.3e-28 98.1 0.0 8.6e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACT03598.1 - 8.5e-20 71.4 0.1 2e-19 70.2 0.0 1.6 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ACT03598.1 - 2.6e-13 49.8 0.8 8.5e-12 44.8 0.2 2.8 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ACT03598.1 - 5.7e-10 38.8 0.7 5.3e-09 35.6 0.2 2.3 1 1 1 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.19 ACT03598.1 - 8.2e-08 31.6 0.1 2.5e-07 30.0 0.0 1.8 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ACT03598.1 - 0.006 16.5 0.2 0.034 14.1 0.2 2.0 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 ACT03598.1 - 0.14 12.1 0.2 0.63 9.9 0.2 2.0 1 1 1 2 2 2 0 KR domain GDP_Man_Dehyd PF16363.5 ACT03599.1 - 3.5e-97 325.8 0.0 4e-97 325.6 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ACT03599.1 - 1.3e-70 237.6 0.0 1.6e-70 237.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ACT03599.1 - 2.1e-16 59.8 0.0 2.7e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ACT03599.1 - 4.2e-16 58.9 0.0 5.1e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ACT03599.1 - 3.6e-14 52.6 0.0 5.3e-14 52.0 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ACT03599.1 - 4.9e-13 48.8 0.0 3.7e-10 39.4 0.0 2.6 1 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 ACT03599.1 - 6.9e-11 42.4 0.0 1.5e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 ACT03599.1 - 0.0037 16.7 0.0 1.8 8.0 0.0 2.4 2 1 0 2 2 2 2 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 ACT03599.1 - 0.0044 17.3 0.0 0.01 16.1 0.0 1.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 ACT03599.1 - 0.033 13.7 0.0 0.081 12.5 0.0 1.7 2 1 0 2 2 2 0 NmrA-like family KR PF08659.10 ACT03599.1 - 0.11 12.4 0.0 0.57 10.1 0.0 2.0 2 1 0 2 2 2 0 KR domain dTDP_sugar_isom PF00908.17 ACT03600.1 - 3.5e-72 241.6 0.0 3.9e-72 241.4 0.0 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase ABC2_membrane_2 PF12679.7 ACT03601.1 - 4.1e-19 69.0 33.5 3.7e-18 65.8 33.5 1.9 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 ACT03601.1 - 2.6e-17 63.4 21.3 2.6e-17 63.4 21.3 1.9 2 0 0 2 2 2 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 ACT03601.1 - 0.00034 20.1 24.7 0.00034 20.1 24.7 2.1 2 1 0 2 2 2 1 ABC-2 type transporter DUF2705 PF10920.8 ACT03601.1 - 0.0014 18.0 21.7 0.0014 18.0 21.7 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF2705) ABC2_membrane_5 PF13346.6 ACT03601.1 - 0.002 17.7 29.1 0.002 17.7 29.1 3.0 1 1 1 2 2 2 1 ABC-2 family transporter protein TctB PF07331.11 ACT03601.1 - 0.0023 18.2 27.2 0.044 14.1 9.3 3.1 3 0 0 3 3 3 2 Tripartite tricarboxylate transporter TctB family ABC2_membrane_3 PF12698.7 ACT03601.1 - 0.78 8.8 38.2 0.056 12.5 32.1 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein CRPA PF05745.11 ACT03601.1 - 8 6.5 18.3 0.78 9.7 5.7 2.8 1 1 2 3 3 3 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) ABC_tran PF00005.27 ACT03602.1 - 4.7e-28 98.4 0.0 7.3e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT03602.1 - 1.6e-12 47.9 0.5 4.2e-08 33.3 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ACT03602.1 - 0.0084 16.6 0.1 0.018 15.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 ACT03602.1 - 0.0093 15.7 0.0 2.1 8.0 0.0 2.2 1 1 1 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 ACT03602.1 - 0.01 15.3 0.0 5 6.5 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT03602.1 - 0.039 14.2 0.2 0.6 10.4 0.2 2.3 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ACT03602.1 - 0.071 13.5 0.0 0.18 12.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 ACT03602.1 - 0.085 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 ACT03602.1 - 0.085 12.6 0.5 0.27 11.0 0.4 1.8 1 1 1 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.17 ACT03602.1 - 0.17 11.9 0.1 0.32 11.0 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE LytR_cpsA_psr PF03816.14 ACT03603.1 - 4.4e-46 156.8 0.0 6.7e-46 156.2 0.0 1.3 1 0 0 1 1 1 1 Cell envelope-related transcriptional attenuator domain DUF3887 PF13026.6 ACT03603.1 - 0.049 14.4 0.5 0.18 12.6 0.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3887) NTP_transferase PF00483.23 ACT03604.1 - 3.6e-14 53.0 0.0 5.2e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACT03604.1 - 2.6e-09 37.6 0.0 6.8e-09 36.3 0.0 1.7 2 0 0 2 2 2 1 MobA-like NTP transferase domain MannoseP_isomer PF01050.18 ACT03604.1 - 0.0006 19.7 0.0 0.0013 18.6 0.0 1.7 1 1 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.11 ACT03604.1 - 0.04 13.6 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 Cupin domain AAA_31 PF13614.6 ACT03605.1 - 8.9e-18 64.8 0.1 1.7e-17 63.9 0.1 1.5 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 ACT03605.1 - 3.4e-16 59.4 0.0 8.7e-16 58.1 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 ACT03605.1 - 2.4e-12 46.8 0.5 4.7e-12 45.9 0.2 1.6 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 ACT03605.1 - 7.5e-11 42.0 0.0 1e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 ACT03605.1 - 1.3e-07 31.4 0.0 4.5e-07 29.6 0.0 1.7 1 1 1 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 ACT03605.1 - 2.7e-07 30.2 0.0 1.3e-06 27.9 0.0 2.0 1 1 0 1 1 1 1 ATPase MipZ SRP54 PF00448.22 ACT03605.1 - 5.8e-06 26.1 0.5 1.3e-05 24.9 0.1 1.9 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_26 PF13500.6 ACT03605.1 - 0.00019 21.3 0.6 0.13 12.0 0.2 2.3 2 0 0 2 2 2 2 AAA domain ArsA_ATPase PF02374.15 ACT03605.1 - 0.00027 20.2 0.7 0.015 14.5 0.2 2.3 1 1 0 2 2 2 1 Anion-transporting ATPase VirC1 PF07015.11 ACT03605.1 - 0.0016 17.8 0.1 0.0025 17.1 0.1 1.3 1 0 0 1 1 1 1 VirC1 protein CLP1_P PF16575.5 ACT03605.1 - 0.0026 17.6 0.1 0.0046 16.8 0.1 1.5 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 ACT03605.1 - 0.018 14.7 0.1 0.074 12.8 0.1 2.2 1 1 0 1 1 1 0 AAA domain PTPlike_phytase PF14566.6 ACT03605.1 - 0.032 14.3 0.0 0.067 13.3 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF853 PF05872.12 ACT03605.1 - 0.05 12.2 0.2 0.24 10.0 0.1 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) DnaB_C PF03796.15 ACT03605.1 - 0.065 12.6 0.2 7.2 5.9 0.1 2.1 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 ACT03605.1 - 0.095 12.0 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin PilZ PF07238.14 ACT03606.1 - 4.3e-10 39.8 0.0 5e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 PilZ domain HTH_3 PF01381.22 ACT03607.1 - 3.8e-17 62.1 0.2 8.3e-17 61.0 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix HTH_19 PF12844.7 ACT03607.1 - 1.1e-14 54.1 0.4 3.7e-14 52.5 0.1 1.9 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_31 PF13560.6 ACT03607.1 - 9.5e-13 48.3 0.5 6.4e-12 45.6 0.1 2.1 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_26 PF13443.6 ACT03607.1 - 3.1e-05 24.3 0.0 5.2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_37 PF13744.6 ACT03607.1 - 5.1e-05 23.1 0.1 0.00084 19.3 0.1 2.2 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 ACT03607.1 - 0.0059 16.4 0.2 0.012 15.3 0.2 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4 PF04545.16 ACT03607.1 - 0.01 15.3 0.2 0.029 13.9 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_25 PF13413.6 ACT03607.1 - 0.013 15.3 0.4 0.039 13.8 0.2 1.9 2 1 0 2 2 2 0 Helix-turn-helix domain Death PF00531.22 ACT03607.1 - 0.027 14.7 0.2 4.2 7.6 0.0 2.1 1 1 1 2 2 2 0 Death domain DUF1160 PF06648.11 ACT03607.1 - 0.058 13.4 0.1 0.5 10.4 0.1 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1160) DUF2975 PF11188.8 ACT03608.1 - 3e-28 98.3 6.0 3e-28 98.3 6.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF2975) DUF4271 PF14093.6 ACT03608.1 - 0.16 11.9 7.0 0.21 11.5 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) TctB PF07331.11 ACT03608.1 - 0.47 10.7 12.4 3 8.1 12.4 1.9 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF2070 PF09843.9 ACT03608.1 - 0.84 7.8 10.2 1.1 7.5 10.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) GATase_2 PF00310.21 ACT03609.1 - 9.6e-187 620.8 0.0 1.2e-186 620.5 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 ACT03609.1 - 8.9e-155 515.4 0.2 3.4e-152 506.9 0.0 3.0 3 0 0 3 3 3 2 Conserved region in glutamate synthase Glu_syn_central PF04898.14 ACT03609.1 - 1.4e-120 402.0 0.0 1e-118 395.9 0.0 2.2 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 ACT03609.1 - 9.4e-85 283.0 6.9 1.6e-84 282.3 6.9 1.4 1 0 0 1 1 1 1 GXGXG motif GATase_6 PF13522.6 ACT03609.1 - 0.036 14.3 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 Glutamine amidotransferase domain Tti2 PF10521.9 ACT03609.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Tti2 family FMN_dh PF01070.18 ACT03609.1 - 0.39 9.7 3.9 2.7 6.9 0.2 3.5 5 0 0 5 5 5 0 FMN-dependent dehydrogenase Cu_amine_oxidN1 PF07833.11 ACT03610.1 - 3e-20 72.5 0.0 7.7e-20 71.2 0.0 1.8 1 0 0 1 1 1 1 Copper amine oxidase N-terminal domain Lipase_GDSL_2 PF13472.6 ACT03610.1 - 5.7e-16 59.4 0.0 1.1e-15 58.5 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ACT03610.1 - 2.6e-11 43.9 0.0 4.5e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF4777 PF16007.5 ACT03610.1 - 0.062 13.6 0.0 0.34 11.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4777) KapB PF08810.10 ACT03611.1 - 5.7e-42 142.4 0.0 6.5e-42 142.2 0.0 1.0 1 0 0 1 1 1 1 Kinase associated protein B MGDG_synth PF06925.11 ACT03612.1 - 5.6e-27 94.9 0.0 8.2e-27 94.4 0.0 1.3 1 0 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.16 ACT03612.1 - 1.2e-07 31.9 0.0 2.1e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glycos_transf_1 PF00534.20 ACT03612.1 - 5.3e-06 26.1 0.0 1.6e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT03612.1 - 0.0017 18.7 0.0 0.0045 17.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 ACT03612.1 - 0.11 12.5 0.1 0.37 10.8 0.1 1.8 1 1 1 2 2 2 0 Glycosyl transferase 4-like malic PF00390.19 ACT03613.1 - 1e-30 106.9 0.0 2.5e-28 99.1 0.0 2.6 1 1 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.15 ACT03613.1 - 1.1e-27 96.9 1.4 1.2e-25 90.2 1.4 2.6 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain ELFV_dehydrog PF00208.21 ACT03613.1 - 0.011 15.5 0.2 0.053 13.2 0.0 2.0 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Shikimate_DH PF01488.20 ACT03613.1 - 0.012 15.7 0.0 0.037 14.1 0.0 1.9 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 ACT03613.1 - 0.012 15.0 0.5 0.012 15.0 0.5 1.6 2 0 0 2 2 2 0 ThiF family ACT_4 PF13291.6 ACT03613.1 - 0.02 15.5 0.9 0.067 13.8 0.2 2.3 2 0 0 2 2 1 0 ACT domain AdoHcyase_NAD PF00670.21 ACT03613.1 - 0.023 14.8 0.4 10 6.2 0.2 3.0 3 0 0 3 3 3 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF2252 PF10009.9 ACT03613.1 - 0.047 12.8 0.0 0.077 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) TrkA_N PF02254.18 ACT03613.1 - 0.049 13.9 1.0 0.57 10.5 0.0 3.2 3 0 0 3 3 3 0 TrkA-N domain Palm_thioest PF02089.15 ACT03613.1 - 0.057 13.3 0.0 0.087 12.6 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Patatin PF01734.22 ACT03613.1 - 0.2 11.8 0.3 0.69 10.1 0.0 2.0 2 0 0 2 2 2 0 Patatin-like phospholipase Acyl_transf_3 PF01757.22 ACT03614.1 - 8.2e-31 107.3 52.3 9.6e-31 107.1 52.3 1.0 1 0 0 1 1 1 1 Acyltransferase family Polysacc_deac_1 PF01522.21 ACT03615.1 - 1.3e-24 86.4 0.1 2.1e-24 85.8 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase RAP PF08373.10 ACT03615.1 - 0.055 13.6 0.8 0.13 12.4 0.1 2.0 2 0 0 2 2 2 0 RAP domain MutS_I PF01624.20 ACT03615.1 - 0.083 13.1 0.2 1.8 8.8 0.0 2.7 2 1 1 3 3 3 0 MutS domain I Acyl_transf_3 PF01757.22 ACT03616.1 - 2.2e-28 99.3 48.6 2.6e-28 99.1 48.6 1.0 1 0 0 1 1 1 1 Acyltransferase family CBP_BcsF PF11120.8 ACT03616.1 - 0.0094 16.1 1.3 0.03 14.4 1.3 1.8 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsF Cation_efflux PF01545.21 ACT03617.1 - 1.2e-51 175.3 8.0 1.5e-51 174.9 8.0 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ACT03617.1 - 1.4e-17 63.6 3.7 2.3e-17 62.9 3.7 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF3493 PF11998.8 ACT03617.1 - 0.8 9.9 5.3 0.6 10.3 1.0 2.5 1 1 1 2 2 2 0 Low psii accumulation1 / Rep27 ABC_tran PF00005.27 ACT03618.1 - 1.3e-40 139.1 0.1 3.6e-23 82.6 0.0 3.6 4 1 0 4 4 3 2 ABC transporter ABC_tran_Xtn PF12848.7 ACT03618.1 - 3e-20 72.0 1.1 3e-20 72.0 1.1 1.8 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ACT03618.1 - 5.1e-12 46.2 7.8 0.00062 19.7 0.0 4.5 4 1 0 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT03618.1 - 6.5e-08 32.3 0.0 0.00062 19.3 0.0 3.1 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT03618.1 - 0.00021 20.9 0.0 0.017 14.9 0.0 3.2 3 0 0 3 3 3 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT03618.1 - 0.00023 21.1 0.2 0.039 13.9 0.0 3.0 3 1 0 3 3 3 1 RsgA GTPase RNA_helicase PF00910.22 ACT03618.1 - 0.0024 18.2 0.5 4.6 7.7 0.0 4.5 4 1 1 5 5 5 1 RNA helicase KAP_NTPase PF07693.14 ACT03618.1 - 0.015 14.6 0.0 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 KAP family P-loop domain NB-ARC PF00931.22 ACT03618.1 - 0.015 14.5 0.0 0.015 14.5 0.0 2.4 3 0 0 3 3 3 0 NB-ARC domain MMR_HSR1 PF01926.23 ACT03618.1 - 0.017 15.2 0.0 0.18 11.9 0.0 2.6 3 0 0 3 3 3 0 50S ribosome-binding GTPase ATP-synt_ab PF00006.25 ACT03618.1 - 0.021 14.5 0.0 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.23 ACT03618.1 - 0.088 12.9 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Dynamin family AAA_7 PF12775.7 ACT03618.1 - 0.1 12.1 0.2 0.94 9.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 ACT03618.1 - 0.12 12.8 0.3 61 4.1 0.0 3.7 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ACT03618.1 - 0.15 12.5 13.3 0.41 11.1 9.9 2.8 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ACT03618.1 - 0.94 9.1 9.6 6.4 6.4 9.5 2.5 1 1 0 1 1 1 0 AAA ATPase domain GFO_IDH_MocA PF01408.22 ACT03619.1 - 1.9e-26 93.2 0.7 3e-26 92.6 0.7 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03619.1 - 1.9e-10 40.7 0.0 3.9e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACT03619.1 - 2.1e-06 28.4 0.3 3.4e-06 27.7 0.3 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ACT03619.1 - 0.00026 21.2 0.1 0.00058 20.1 0.1 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 ACT03619.1 - 0.00054 20.5 0.1 0.001 19.6 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.9 ACT03619.1 - 0.009 15.9 0.1 0.016 15.1 0.1 1.4 1 0 0 1 1 1 1 Rossmann-like domain 2-Hacid_dh_C PF02826.19 ACT03619.1 - 0.04 13.3 0.0 0.07 12.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 ACT03619.1 - 0.049 13.3 0.0 0.083 12.5 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA OCD_Mu_crystall PF02423.15 ACT03619.1 - 0.07 12.1 0.3 0.092 11.7 0.3 1.1 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Lactamase_B_2 PF12706.7 ACT03620.1 - 1.1e-42 145.8 0.1 1.5e-42 145.4 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ACT03620.1 - 4.2e-24 85.3 0.0 5.5e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACT03620.1 - 9.5e-06 25.7 2.3 2e-05 24.7 0.6 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily HEAT_2 PF13646.6 ACT03621.1 - 1.8e-37 127.6 16.6 1.6e-12 47.6 1.0 3.4 2 1 3 5 5 5 4 HEAT repeats Virulence_fact PF13769.6 ACT03621.1 - 1.7e-28 98.6 0.4 1.7e-28 98.6 0.4 2.5 3 0 0 3 3 3 1 Virulence factor Nfu_N PF08712.11 ACT03621.1 - 4.7e-15 55.4 0.0 8.6e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal HEAT PF02985.22 ACT03621.1 - 1.7e-13 49.6 1.9 0.0036 17.4 0.1 5.1 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 ACT03621.1 - 8.3e-06 26.2 3.3 0.2 12.2 0.0 4.7 3 2 1 4 4 4 2 HEAT-like repeat HEAT_PBS PF03130.16 ACT03621.1 - 0.00014 22.3 11.7 0.0022 18.5 0.7 5.1 6 0 0 6 6 6 2 PBS lyase HEAT-like repeat Cnd1 PF12717.7 ACT03621.1 - 0.00057 20.0 0.2 0.39 10.8 0.0 3.3 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ACT03621.1 - 0.0035 16.0 0.0 0.013 14.1 0.0 1.8 2 0 0 2 2 2 1 Adaptin N terminal region Cohesin_HEAT PF12765.7 ACT03621.1 - 0.064 13.6 0.1 48 4.4 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Transglut_core PF01841.19 ACT03622.1 - 5.4e-14 52.6 0.3 2e-13 50.8 0.1 2.1 2 0 0 2 2 2 1 Transglutaminase-like superfamily DUF553 PF04473.12 ACT03622.1 - 0.0025 17.4 1.1 0.0056 16.2 0.7 1.7 1 1 0 1 1 1 1 Transglutaminase-like domain Sulfatase PF00884.23 ACT03623.1 - 1.1e-35 123.5 0.5 1.5e-35 123.1 0.5 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACT03623.1 - 0.011 15.3 0.1 0.036 13.7 0.1 1.9 1 1 1 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 ACT03623.1 - 0.083 11.5 0.0 0.14 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF229) CheD PF03975.13 ACT03623.1 - 0.13 12.4 0.0 0.93 9.6 0.0 2.2 2 0 0 2 2 2 0 CheD chemotactic sensory transduction Glyco_hydro_2_N PF02837.18 ACT03624.1 - 4.2e-25 88.6 0.9 1.4e-24 86.9 0.9 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 ACT03624.1 - 9.4e-15 54.5 2.6 1.1e-13 51.0 2.6 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ACT03624.1 - 1.9e-09 38.1 0.0 4.2e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 ACT03624.1 - 3.9e-06 27.4 0.1 8.8e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 Beta-galactosidase jelly roll domain Glyco_hydro_43 PF04616.14 ACT03625.1 - 6.5e-39 134.0 4.2 1.5e-38 132.8 4.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 ACT03625.1 - 3e-05 23.8 0.2 0.016 14.8 0.1 2.5 2 0 0 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_130 PF04041.13 ACT03625.1 - 0.0092 14.9 0.3 0.24 10.3 0.1 2.4 2 0 0 2 2 2 1 beta-1,4-mannooligosaccharide phosphorylase Methyltr_RsmF_N PF17125.5 ACT03625.1 - 0.23 12.0 0.4 3.3 8.3 0.0 2.5 2 0 0 2 2 2 0 N-terminal domain of 16S rRNA methyltransferase RsmF BPD_transp_1 PF00528.22 ACT03626.1 - 1.8e-20 73.5 17.0 1.8e-20 73.5 17.0 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT03627.1 - 1.5e-19 70.4 16.4 1.5e-19 70.4 16.4 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_1 PF01547.25 ACT03628.1 - 1e-40 140.6 23.1 1.8e-40 139.9 23.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT03628.1 - 3.1e-30 105.9 15.2 3.1e-30 105.9 15.2 1.5 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT03628.1 - 0.00026 20.5 0.2 0.00045 19.7 0.2 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3357 PF11837.8 ACT03628.1 - 0.085 13.3 0.1 0.19 12.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) HTH_24 PF13412.6 ACT03629.1 - 4.6e-08 32.5 0.4 8.3e-08 31.7 0.4 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 ACT03629.1 - 8.3e-07 29.0 0.2 1.4e-06 28.3 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 ACT03629.1 - 0.00046 20.1 0.2 0.0011 18.9 0.2 1.6 1 0 0 1 1 1 1 MarR family HTH_5 PF01022.20 ACT03629.1 - 0.00097 19.0 0.1 0.0019 18.1 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 ACT03629.1 - 0.0012 18.7 0.1 0.0025 17.7 0.1 1.5 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 ACT03629.1 - 0.062 13.2 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.6 ACT03629.1 - 0.08 12.8 0.1 0.18 11.6 0.0 1.6 2 0 0 2 2 2 0 Homeodomain-like domain LysR_substrate PF03466.20 ACT03630.1 - 3.7e-41 140.8 0.0 4.9e-41 140.4 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT03630.1 - 3.4e-16 58.9 0.2 7.1e-16 57.9 0.1 1.7 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family ABM PF03992.16 ACT03631.1 - 6.2e-08 32.6 0.1 7.9e-08 32.3 0.1 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF4188 PF13826.6 ACT03631.1 - 3.4e-05 24.2 0.1 4.3e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) DUF3291 PF11695.8 ACT03631.1 - 0.017 14.8 0.4 0.054 13.2 0.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3291) Dabb PF07876.12 ACT03631.1 - 0.084 13.5 0.0 0.1 13.2 0.0 1.1 1 0 0 1 1 1 0 Stress responsive A/B Barrel Domain MarR PF01047.22 ACT03632.1 - 2.8e-14 52.8 0.0 6.8e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT03632.1 - 1.7e-07 31.7 0.2 3.4e-07 30.6 0.0 1.6 2 0 0 2 2 2 1 Winged helix DNA-binding domain TrmB PF01978.19 ACT03632.1 - 1.6e-06 27.9 0.1 4.5e-05 23.3 0.0 2.3 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 ACT03632.1 - 7e-06 25.8 0.0 1.6e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 ACT03632.1 - 0.00026 20.9 0.1 0.00059 19.8 0.0 1.7 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain GntR PF00392.21 ACT03632.1 - 0.00039 20.0 0.0 0.00081 19.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_24 PF13412.6 ACT03632.1 - 0.0027 17.2 0.0 0.008 15.7 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 ACT03632.1 - 0.0044 16.9 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 HTH domain Fe_dep_repress PF01325.19 ACT03632.1 - 0.012 15.8 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain DUF4423 PF14394.6 ACT03632.1 - 0.014 15.1 1.4 0.24 11.1 1.4 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4423) DUF3116 PF11313.8 ACT03632.1 - 0.019 14.8 0.2 0.032 14.1 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3116) HTH_36 PF13730.6 ACT03632.1 - 0.024 14.6 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain PelD_GGDEF PF16963.5 ACT03632.1 - 0.057 13.2 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 PelD GGDEF domain PadR PF03551.14 ACT03632.1 - 0.068 13.1 0.1 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family PNPase PF03726.14 ACT03632.1 - 0.12 12.9 2.8 0.12 12.9 1.2 1.8 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain HTH_AsnC-type PF13404.6 ACT03632.1 - 0.13 12.1 1.1 0.19 11.6 0.1 1.8 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Acetyltransf_10 PF13673.7 ACT03633.1 - 8.8e-20 70.9 0.0 9.9e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT03633.1 - 1.7e-13 50.8 0.2 2.1e-13 50.5 0.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT03633.1 - 6.4e-11 42.5 0.4 9.6e-11 42.0 0.4 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT03633.1 - 0.0007 19.7 0.0 0.025 14.6 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT03633.1 - 0.00084 19.3 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_5 PF13444.6 ACT03633.1 - 0.004 17.8 0.3 0.012 16.3 0.0 1.9 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Bac_rhamnosid6H PF17389.2 ACT03635.1 - 1.6e-40 139.4 0.0 2.1e-40 139.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid PF05592.11 ACT03635.1 - 4.8e-16 58.6 0.0 8.1e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_N PF08531.10 ACT03635.1 - 6.8e-16 58.6 0.6 1.4e-15 57.5 0.6 1.5 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid_C PF17390.2 ACT03635.1 - 5.6e-05 22.8 0.0 0.00011 21.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Glyco_hydro_2_N PF02837.18 ACT03635.1 - 0.00021 21.2 0.0 0.00047 20.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain GDE_C PF06202.14 ACT03635.1 - 0.0008 18.4 0.0 0.0013 17.7 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase DUF608 PF04685.13 ACT03635.1 - 0.0021 17.3 0.1 0.004 16.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region DUF5639 PF18690.1 ACT03635.1 - 0.027 14.6 0.0 1.8 8.8 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5639) DZR PF12773.7 ACT03636.1 - 0.00016 21.6 5.3 0.00018 21.5 1.2 2.3 2 1 0 2 2 2 1 Double zinc ribbon Auto_anti-p27 PF06677.12 ACT03636.1 - 0.00053 20.1 2.8 0.00053 20.1 2.8 2.1 2 0 0 2 2 2 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-ribbon_3 PF13248.6 ACT03636.1 - 0.00077 18.8 3.4 0.00077 18.8 3.4 1.8 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_2 PF13240.6 ACT03636.1 - 0.005 16.5 2.3 0.005 16.5 2.3 2.1 2 0 0 2 2 2 1 zinc-ribbon domain C1_1 PF00130.22 ACT03636.1 - 0.19 11.6 6.8 0.13 12.2 0.8 2.8 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-dskA_traR PF01258.17 ACT03636.1 - 0.23 11.4 5.0 54 3.8 5.0 2.7 1 1 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger zf_UBZ PF18439.1 ACT03636.1 - 0.25 11.0 6.8 3 7.5 0.3 3.1 2 1 1 3 3 3 0 Ubiquitin-Binding Zinc Finger YhfH PF14149.6 ACT03636.1 - 0.34 10.9 4.5 3.5 7.7 0.3 2.7 1 1 1 2 2 2 0 YhfH-like protein NMD3 PF04981.13 ACT03636.1 - 0.49 9.8 6.5 0.25 10.8 1.4 2.0 2 0 0 2 2 2 0 NMD3 family zinc_ribbon_9 PF14369.6 ACT03636.1 - 0.62 10.4 11.7 0.22 11.8 0.9 3.2 2 1 1 3 3 3 0 zinc-ribbon DUF1610 PF07754.11 ACT03636.1 - 1.1 9.3 9.1 13 5.9 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) HypA PF01155.19 ACT03636.1 - 1.5 8.9 4.0 17 5.5 4.0 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3139 PF11337.8 ACT03637.1 - 0.056 14.1 0.6 0.057 14.1 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) DIM PF08194.12 ACT03637.1 - 0.095 12.9 0.6 0.15 12.3 0.6 1.4 1 0 0 1 1 1 0 DIM protein Aldose_epim PF01263.20 ACT03638.1 - 1.8e-36 126.0 0.0 2e-36 125.9 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase DUF4432 PF14486.6 ACT03638.1 - 0.012 14.4 0.0 0.015 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4432) Glyco_hydro_127 PF07944.12 ACT03639.1 - 4.8e-60 203.5 0.0 5.9e-60 203.2 0.0 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 B9-C2 PF07162.11 ACT03639.1 - 0.14 12.4 0.0 0.34 11.1 0.0 1.7 1 0 0 1 1 1 0 Ciliary basal body-associated, B9 protein HTH_18 PF12833.7 ACT03640.1 - 2.4e-19 69.3 0.0 4.3e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03640.1 - 1.3e-15 57.0 0.0 7.2e-08 32.3 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03640.1 - 0.07 13.0 3.0 0.089 12.7 0.7 2.4 3 0 0 3 3 3 0 AraC-like ligand binding domain Glyco_hydro_76 PF03663.14 ACT03641.1 - 1.6e-44 152.9 0.4 1.9e-44 152.7 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 ACT03641.1 - 0.0007 18.8 7.1 0.03 13.4 0.0 2.3 1 1 1 2 2 2 2 Glycosyl Hydrolase Family 88 PorA PF11271.8 ACT03641.1 - 0.15 11.3 0.0 4.7 6.4 0.0 2.1 2 0 0 2 2 2 0 Porin PorA Glyco_hydro_76 PF03663.14 ACT03642.1 - 5.1e-47 161.1 3.7 6.1e-47 160.9 3.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 ACT03642.1 - 2.8e-07 30.0 5.2 0.004 16.3 1.6 2.2 1 1 1 2 2 2 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 ACT03642.1 - 4.4e-05 23.1 0.9 0.0079 15.7 0.1 2.7 1 1 2 3 3 3 2 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 ACT03642.1 - 0.018 13.6 0.6 0.18 10.2 0.0 2.1 1 1 1 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_9 PF00759.19 ACT03642.1 - 0.32 10.4 7.4 0.52 9.7 0.3 2.1 1 1 1 2 2 2 0 Glycosyl hydrolase family 9 Glyco_hydro_76 PF03663.14 ACT03643.1 - 6.6e-45 154.2 7.3 1e-44 153.6 7.2 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 ACT03643.1 - 6.5e-07 28.8 10.0 0.0075 15.4 9.3 2.4 1 1 1 2 2 2 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 ACT03643.1 - 0.00022 20.8 1.5 3.5 7.1 0.1 4.0 1 1 3 4 4 4 2 D-glucuronyl C5-epimerase C-terminus BPD_transp_1 PF00528.22 ACT03644.1 - 1.5e-22 80.2 20.7 1.5e-22 80.2 20.7 2.0 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2585 PF10755.9 ACT03644.1 - 0.028 14.1 0.3 0.38 10.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2585) BPD_transp_1 PF00528.22 ACT03645.1 - 3.2e-13 49.8 17.3 3.2e-13 49.8 17.3 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component TM_PBP2_N PF16296.5 ACT03645.1 - 0.044 13.9 2.0 0.09 12.9 2.0 1.5 1 0 0 1 1 1 0 N-terminal of TM subunit in PBP-dependent ABC transporters DUF4407 PF14362.6 ACT03645.1 - 0.08 12.3 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SBP_bac_8 PF13416.6 ACT03646.1 - 5.7e-44 151.0 11.7 8.4e-44 150.5 11.7 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT03646.1 - 5.9e-41 141.4 16.9 8.3e-41 141.0 16.9 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Glyco_hydro_125 PF06824.11 ACT03647.1 - 7.5e-153 509.3 0.0 8.7e-153 509.1 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Peripla_BP_3 PF13377.6 ACT03649.1 - 2.4e-22 80.0 0.0 3.8e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein-like domain GntR PF00392.21 ACT03649.1 - 9.1e-19 66.9 0.0 1.9e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Peripla_BP_1 PF00532.21 ACT03649.1 - 9.2e-16 58.1 0.0 1.4e-15 57.4 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT03649.1 - 1.2e-13 51.2 0.0 4.4e-13 49.4 0.0 1.8 1 1 1 2 2 2 2 Periplasmic binding protein domain HTH_41 PF14502.6 ACT03649.1 - 0.022 14.5 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DnaI_N PF07319.11 ACT03649.1 - 0.039 14.6 1.0 0.094 13.4 0.5 1.9 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus ANF_receptor PF01094.28 ACT03649.1 - 0.084 12.0 0.0 1.6 7.7 0.0 2.0 2 0 0 2 2 2 0 Receptor family ligand binding region adh_short PF00106.25 ACT03650.1 - 8.7e-43 146.1 0.1 9.8e-43 145.9 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT03650.1 - 8.6e-37 126.9 0.0 1.1e-36 126.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT03650.1 - 7.3e-12 45.6 0.1 9.1e-12 45.2 0.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ACT03650.1 - 3.3e-05 23.9 0.9 0.0002 21.3 1.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ACT03650.1 - 0.00016 20.9 0.2 0.00029 20.1 0.2 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 ACT03650.1 - 0.00024 20.7 0.7 0.00065 19.2 0.7 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 ACT03650.1 - 0.00037 20.0 0.0 0.00051 19.5 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 ACT03650.1 - 0.0068 16.0 0.4 0.011 15.2 0.4 1.5 1 0 0 1 1 1 1 NmrA-like family Glyco_hydro_66 PF13199.6 ACT03651.1 - 1.9e-129 432.8 16.4 1.5e-83 281.4 11.2 2.4 2 0 0 2 2 2 2 Glycosyl hydrolase family 66 CBM_35 PF16990.5 ACT03651.1 - 8.8e-32 109.9 17.4 3.9e-10 40.0 0.1 6.8 4 1 2 6 6 6 4 Carbohydrate binding module (family 35) SLH PF00395.20 ACT03651.1 - 2.5e-26 91.4 1.5 1.1e-10 41.3 0.1 4.1 3 0 0 3 3 3 3 S-layer homology domain GHL10 PF02638.15 ACT03651.1 - 0.0011 18.2 0.2 0.002 17.3 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase-like 10 DUF5010_C PF18099.1 ACT03651.1 - 0.012 15.7 0.0 0.45 10.7 0.0 3.2 2 0 0 2 2 2 0 DUF5010 C-terminal domain Cadherin-like PF12733.7 ACT03651.1 - 0.059 13.9 10.2 0.2 12.2 0.1 5.7 7 0 0 7 7 7 0 Cadherin-like beta sandwich domain DUF3502 PF12010.8 ACT03652.1 - 1.5e-36 125.9 0.4 1.5e-36 125.9 0.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACT03652.1 - 4.1e-07 30.2 8.9 7.6e-07 29.4 8.9 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3558 PF12079.8 ACT03652.1 - 0.25 11.3 1.8 0.4 10.7 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) BPD_transp_1 PF00528.22 ACT03653.1 - 1.1e-13 51.3 14.2 1.1e-13 51.3 14.2 2.4 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF417 PF04224.12 ACT03653.1 - 0.38 10.3 5.9 0.24 10.9 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF417 DUF639 PF04842.12 ACT03653.1 - 0.62 9.4 5.5 0.28 10.6 0.4 2.6 2 1 1 3 3 3 0 Plant protein of unknown function (DUF639) Adipogenin PF15202.6 ACT03653.1 - 1.2 9.2 5.4 3.8 7.6 0.7 2.7 2 0 0 2 2 2 0 Adipogenin BPD_transp_1 PF00528.22 ACT03654.1 - 6.1e-17 62.0 9.6 6.1e-17 62.0 9.6 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component HTH_18 PF12833.7 ACT03655.1 - 1.5e-23 82.9 0.0 3.8e-23 81.5 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain Response_reg PF00072.24 ACT03655.1 - 4.1e-23 81.7 0.0 8.8e-23 80.6 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT03655.1 - 1.8e-16 59.8 0.0 1.7e-07 31.2 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_Crp_2 PF13545.6 ACT03655.1 - 0.012 15.5 0.0 0.031 14.3 0.0 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_31 PF13560.6 ACT03655.1 - 0.019 15.3 0.0 0.9 9.9 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_3 PF01381.22 ACT03655.1 - 0.024 14.7 0.0 0.11 12.6 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix HTH_23 PF13384.6 ACT03655.1 - 0.044 13.6 0.0 12 5.8 0.0 2.7 2 0 0 2 2 2 0 Homeodomain-like domain His_kinase PF06580.13 ACT03656.1 - 4e-22 78.3 2.5 1.1e-21 77.0 2.5 1.8 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACT03656.1 - 3.4e-07 30.5 0.0 6.6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT03656.1 - 0.0052 17.3 0.0 0.013 16.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Peripla_BP_3 PF13377.6 ACT03657.1 - 1.7e-37 129.3 0.1 8.1e-36 123.8 0.0 2.4 3 0 0 3 3 3 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT03657.1 - 2.4e-34 119.1 0.1 2.9e-34 118.8 0.1 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT03657.1 - 3.2e-20 72.8 0.1 5.5e-20 72.0 0.1 1.4 1 0 0 1 1 1 1 Periplasmic binding protein domain LacI PF00356.21 ACT03657.1 - 1.8e-17 62.9 1.4 4.3e-17 61.6 0.2 2.4 3 0 0 3 3 3 1 Bacterial regulatory proteins, lacI family HTH_3 PF01381.22 ACT03657.1 - 8.8e-05 22.5 0.1 0.11 12.6 0.0 3.3 2 1 1 3 3 3 1 Helix-turn-helix Trp_repressor PF01371.19 ACT03657.1 - 0.0017 18.5 0.1 0.0035 17.4 0.1 1.5 1 0 0 1 1 1 1 Trp repressor protein HTH_7 PF02796.15 ACT03657.1 - 0.0063 16.6 0.1 0.23 11.6 0.0 3.3 3 0 0 3 3 3 1 Helix-turn-helix domain of resolvase HTH_31 PF13560.6 ACT03657.1 - 0.014 15.7 0.0 0.23 11.8 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_23 PF13384.6 ACT03657.1 - 0.023 14.5 0.0 0.5 10.2 0.1 2.4 1 1 1 2 2 2 0 Homeodomain-like domain TrmB PF01978.19 ACT03657.1 - 0.045 13.6 0.1 0.28 11.1 0.0 2.4 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB HTH_Tnp_ISL3 PF13542.6 ACT03657.1 - 0.055 12.9 0.1 0.14 11.6 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 FliG_M PF14841.6 ACT03657.1 - 0.071 13.4 0.0 0.4 11.0 0.0 2.2 2 0 0 2 2 2 0 FliG middle domain HTH_38 PF13936.6 ACT03657.1 - 0.072 12.9 0.7 1.4 8.7 0.2 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_6 PF01418.17 ACT03657.1 - 0.075 13.0 0.0 0.23 11.5 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family TnsD PF15978.5 ACT03657.1 - 0.08 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Tn7-like transposition protein D ThuA PF06283.11 ACT03658.1 - 1.4e-32 113.7 0.3 1.6e-32 113.4 0.3 1.0 1 0 0 1 1 1 1 Trehalose utilisation GFO_IDH_MocA PF01408.22 ACT03659.1 - 7.1e-21 75.3 0.0 1.2e-20 74.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03659.1 - 3e-11 43.4 0.0 5.1e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 ACT03659.1 - 0.052 14.1 0.0 0.13 12.9 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent EF-hand_6 PF13405.6 ACT03659.1 - 0.094 12.7 0.4 1.6 8.8 0.1 2.7 2 0 0 2 2 2 0 EF-hand domain HTH_18 PF12833.7 ACT03660.1 - 1.7e-18 66.7 0.1 4.3e-18 65.3 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03660.1 - 6.6e-13 48.4 0.1 8.7e-10 38.5 0.0 2.9 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03660.1 - 7.4e-07 29.2 0.9 1.6e-06 28.1 0.9 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT03660.1 - 3.5e-05 23.4 0.0 7.7e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding_2 PF14525.6 ACT03660.1 - 0.01 15.5 0.0 0.024 14.3 0.0 1.5 2 0 0 2 2 2 0 AraC-binding-like domain Cupin_3 PF05899.12 ACT03660.1 - 0.017 14.8 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) PocR PF10114.9 ACT03661.1 - 4e-50 169.8 0.4 7.9e-50 168.8 0.4 1.5 1 0 0 1 1 1 1 Sensory domain found in PocR HTH_18 PF12833.7 ACT03661.1 - 8.5e-19 67.6 0.0 1.6e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03661.1 - 2.3e-17 62.6 0.0 1.3e-08 34.7 0.0 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family MarR_2 PF12802.7 ACT03661.1 - 0.082 12.8 0.0 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 MarR family Fe-ADH PF00465.19 ACT03662.1 - 4.3e-61 206.7 2.8 5.5e-61 206.4 2.8 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 ACT03662.1 - 2e-25 90.0 0.2 2.8e-25 89.5 0.2 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 ACT03662.1 - 0.0021 17.2 1.6 0.1 11.7 1.6 2.7 1 1 0 1 1 1 1 3-dehydroquinate synthase Dak1 PF02733.17 ACT03663.1 - 5.6e-125 416.4 6.0 9.4e-125 415.6 6.1 1.4 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 ACT03663.1 - 1e-45 155.8 5.1 1e-45 155.8 5.1 1.7 2 0 0 2 2 2 1 DAK2 domain Img2 PF05046.14 ACT03663.1 - 0.2 12.0 0.1 1.3 9.4 0.0 2.4 2 1 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) adh_short_C2 PF13561.6 ACT03664.1 - 2e-38 132.3 0.0 8.5e-38 130.2 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT03664.1 - 6.2e-33 113.9 0.0 5.1e-32 110.9 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase DUF4882 PF16223.5 ACT03664.1 - 0.034 13.4 0.0 0.048 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4882) DUF4432 PF14486.6 ACT03666.1 - 1.8e-07 30.2 0.0 2.9e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4432) Aldose_epim PF01263.20 ACT03666.1 - 5.8e-06 25.8 0.0 1e-05 25.0 0.0 1.6 2 0 0 2 2 2 1 Aldose 1-epimerase bPH_6 PF10756.9 ACT03666.1 - 0.16 12.1 0.0 0.45 10.6 0.0 1.8 1 0 0 1 1 1 0 Bacterial PH domain DUF5107 PF17128.4 ACT03667.1 - 9.4e-73 245.0 4.0 9.4e-73 245.0 4.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF5107) TPR_2 PF07719.17 ACT03667.1 - 1.1e-20 72.0 58.6 0.0012 18.8 1.2 13.1 14 0 0 14 14 13 7 Tetratricopeptide repeat TPR_14 PF13428.6 ACT03667.1 - 2.1e-17 62.3 41.0 0.058 14.2 0.1 12.2 9 3 3 12 12 12 5 Tetratricopeptide repeat TPR_12 PF13424.6 ACT03667.1 - 2.2e-14 53.5 51.7 1.2e-05 25.5 0.3 10.0 7 2 1 9 9 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 ACT03667.1 - 6.7e-14 51.0 36.9 0.036 13.9 0.7 11.1 13 0 0 13 13 13 6 Tetratricopeptide repeat TPR_16 PF13432.6 ACT03667.1 - 2.3e-11 44.1 60.7 0.00048 20.7 5.0 10.2 8 3 3 11 11 11 6 Tetratricopeptide repeat TPR_8 PF13181.6 ACT03667.1 - 7.2e-09 35.2 35.1 0.84 10.0 0.0 11.4 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_11 PF13414.6 ACT03667.1 - 7.4e-07 28.8 33.5 5.3e-05 22.8 1.8 8.3 8 2 2 10 10 10 3 TPR repeat TPR_19 PF14559.6 ACT03667.1 - 2.1e-06 28.1 49.7 0.12 12.9 2.4 9.3 5 3 2 10 10 10 5 Tetratricopeptide repeat TPR_17 PF13431.6 ACT03667.1 - 7.5e-05 22.8 33.3 0.084 13.3 0.0 10.1 13 0 0 13 13 10 3 Tetratricopeptide repeat TPR_4 PF07721.14 ACT03667.1 - 0.00014 22.1 48.5 1 10.2 0.7 12.4 14 0 0 14 14 12 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ACT03667.1 - 0.0023 18.1 27.4 0.37 11.0 0.8 6.8 6 1 1 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 ACT03667.1 - 0.003 17.6 4.7 0.57 10.3 0.0 3.6 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 ACT03667.1 - 0.0035 17.9 40.4 1.3 9.8 0.1 11.0 13 0 0 13 13 12 2 Tetratricopeptide repeat TPR_20 PF14561.6 ACT03667.1 - 0.023 15.0 23.4 1.4 9.3 0.6 6.6 7 1 1 8 8 6 0 Tetratricopeptide repeat PPR PF01535.20 ACT03667.1 - 0.027 14.7 0.9 69 4.0 0.0 4.9 6 0 0 6 6 4 0 PPR repeat Alkyl_sulf_dimr PF14863.6 ACT03667.1 - 0.078 13.4 0.1 0.078 13.4 0.1 3.1 4 0 0 4 4 3 0 Alkyl sulfatase dimerisation TPR_21 PF09976.9 ACT03667.1 - 0.37 10.5 15.2 0.74 9.5 0.1 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 ACT03667.1 - 0.73 9.8 48.2 0.31 11.0 0.2 10.9 12 1 0 12 12 12 0 Tetratricopeptide repeat HTH_AraC PF00165.23 ACT03668.1 - 2.9e-22 78.2 0.0 1.2e-10 41.2 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT03668.1 - 3e-19 69.1 0.0 6.4e-19 68.0 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT03668.1 - 1.4e-18 67.1 0.2 3e-18 66.0 0.1 1.7 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT03668.1 - 2.8e-07 30.2 0.1 5e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 ACT03668.1 - 0.0085 15.8 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Cupin TetR_N PF00440.23 ACT03668.1 - 0.14 11.9 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family Melibiase PF02065.18 ACT03669.1 - 1.4e-121 405.7 0.0 1.8e-121 405.4 0.0 1.1 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 ACT03669.1 - 4.1e-64 216.6 0.0 5.5e-64 216.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 N-terminal domain Glyco_hydro_36C PF16874.5 ACT03669.1 - 6.2e-16 58.6 0.0 1.5e-15 57.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 C-terminal domain GHL10 PF02638.15 ACT03669.1 - 1.6e-05 24.1 0.1 2.6e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase-like 10 Melibiase_2 PF16499.5 ACT03669.1 - 0.0018 17.5 0.0 0.0033 16.6 0.0 1.3 1 0 0 1 1 1 1 Alpha galactosidase A Sulfatase PF00884.23 ACT03670.1 - 3.9e-35 121.7 0.3 5.2e-35 121.3 0.3 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACT03670.1 - 0.00017 21.3 0.0 0.041 13.5 0.0 2.4 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 ACT03670.1 - 0.057 12.0 0.0 0.087 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Response_reg PF00072.24 ACT03671.1 - 1.4e-24 86.4 0.0 3.1e-24 85.3 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT03671.1 - 4.8e-20 71.2 0.2 2e-09 37.3 0.0 3.3 4 0 0 4 4 4 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT03671.1 - 2.2e-19 69.5 0.0 6.6e-19 68.0 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain dCache_1 PF02743.18 ACT03672.1 - 1.5e-23 83.9 0.2 2.5e-23 83.2 0.2 1.3 1 0 0 1 1 1 1 Cache domain His_kinase PF06580.13 ACT03672.1 - 2.8e-20 72.4 0.2 6.9e-20 71.2 0.2 1.6 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACT03672.1 - 1.6e-08 34.7 0.3 6.7e-08 32.8 0.3 2.2 3 0 0 3 3 3 1 HAMP domain HATPase_c PF02518.26 ACT03672.1 - 1.5e-05 25.5 0.0 2.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Clusterin PF01093.17 ACT03672.1 - 0.1 11.7 0.1 0.15 11.1 0.1 1.1 1 0 0 1 1 1 0 Clusterin BPD_transp_1 PF00528.22 ACT03674.1 - 7.3e-11 42.1 19.3 7.3e-11 42.1 19.3 2.0 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component COX2_TM PF02790.15 ACT03674.1 - 1.4 9.2 8.1 2 8.6 0.5 3.4 3 1 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain BPD_transp_1 PF00528.22 ACT03675.1 - 4.2e-15 56.0 9.5 4.2e-15 56.0 9.5 2.1 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Ig_mannosidase PF17753.1 ACT03676.1 - 7.4e-15 54.5 0.1 2.5e-14 52.8 0.1 2.0 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2 PF00703.21 ACT03676.1 - 5.6e-13 49.5 0.1 8.5e-12 45.7 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Mannosidase_ig PF17786.1 ACT03676.1 - 2e-10 41.1 0.2 5e-10 39.8 0.2 1.7 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_N PF02837.18 ACT03676.1 - 4.5e-08 33.2 0.0 1e-07 32.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 ACT03676.1 - 0.0085 15.2 0.7 0.033 13.3 0.7 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain HTH_18 PF12833.7 ACT03677.1 - 2.5e-22 78.9 0.0 4.7e-22 78.1 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT03677.1 - 3.3e-15 56.2 1.5 8.1e-15 54.9 0.4 2.1 1 1 1 2 2 2 1 AraC-like ligand binding domain HTH_AraC PF00165.23 ACT03677.1 - 4.9e-12 45.6 0.0 4e-07 30.0 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT03677.1 - 3.4e-07 29.9 0.2 6.3e-07 29.0 0.2 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding_2 PF14525.6 ACT03677.1 - 0.00028 20.6 0.0 0.00054 19.7 0.0 1.4 1 0 0 1 1 1 1 AraC-binding-like domain dCache_1 PF02743.18 ACT03678.1 - 4.6e-26 92.1 0.8 4.6e-26 92.1 0.8 1.8 2 0 0 2 2 2 1 Cache domain His_kinase PF06580.13 ACT03678.1 - 4e-25 87.9 0.0 1.3e-24 86.3 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase HATPase_c PF02518.26 ACT03678.1 - 5.8e-11 42.9 0.1 2.2e-10 41.0 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT03678.1 - 0.00013 21.8 0.0 0.00025 20.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT03678.1 - 0.0075 16.2 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 GHKL domain Response_reg PF00072.24 ACT03679.1 - 5.3e-31 107.1 0.0 3.6e-30 104.4 0.0 2.2 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT03679.1 - 1.8e-18 66.6 0.0 3.7e-18 65.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03679.1 - 2.4e-15 56.2 0.1 1.2e-07 31.6 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT03679.1 - 2.7e-11 43.8 0.0 2.7e-10 40.5 0.0 2.2 2 0 0 2 2 2 1 GGDEF-like domain YodL PF14191.6 ACT03679.1 - 0.0012 19.7 0.4 0.11 13.4 0.0 2.9 3 0 0 3 3 3 1 YodL-like dCache_3 PF14827.6 ACT03679.1 - 0.053 13.2 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 Double sensory domain of two-component sensor kinase BcsB PF03170.13 ACT03679.1 - 0.14 10.5 0.0 0.2 10.0 0.0 1.1 1 0 0 1 1 1 0 Bacterial cellulose synthase subunit FAD_oxidored PF12831.7 ACT03680.1 - 1.6e-96 324.3 2.5 1.2e-94 318.2 2.5 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ACT03680.1 - 1.6e-10 40.6 4.2 1.8e-09 37.2 2.5 2.2 1 1 1 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 ACT03680.1 - 6.1e-10 38.8 2.2 7.2e-07 28.7 1.4 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT03680.1 - 2.1e-08 34.2 3.3 0.00014 21.6 2.5 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 ACT03680.1 - 1.2e-07 31.2 1.0 2.2e-07 30.3 1.0 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ACT03680.1 - 1.3e-07 31.2 2.5 0.00076 18.8 1.2 2.6 2 1 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 ACT03680.1 - 3.9e-07 29.1 3.1 6.6e-07 28.4 2.4 1.7 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 ACT03680.1 - 1.4e-06 28.5 1.4 4.6e-06 26.8 0.8 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ACT03680.1 - 2e-06 27.2 0.2 4.8e-06 26.0 0.2 1.6 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 ACT03680.1 - 3e-06 26.4 2.1 0.058 12.2 0.0 3.0 3 0 0 3 3 3 2 Tryptophan halogenase AlaDh_PNT_C PF01262.21 ACT03680.1 - 3.2e-05 23.3 0.1 8.4e-05 22.0 0.1 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 ACT03680.1 - 3.6e-05 23.2 0.2 0.00014 21.2 0.2 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT03680.1 - 6.2e-05 23.5 1.8 0.027 15.0 0.4 2.7 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ACT03680.1 - 0.0038 16.3 0.0 0.0057 15.7 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein LDcluster4 PF18306.1 ACT03680.1 - 0.0087 15.7 0.1 0.016 14.8 0.1 1.5 1 0 0 1 1 1 1 SLOG cluster4 family SBP_bac_8 PF13416.6 ACT03681.1 - 3.9e-19 69.6 3.5 7.6e-19 68.6 3.5 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT03681.1 - 5.4e-19 69.3 13.3 5.4e-19 69.3 13.3 1.8 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT03682.1 - 5.9e-13 49.0 6.7 5.9e-13 49.0 6.7 2.4 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT03683.1 - 4.5e-15 55.8 11.9 4.5e-15 55.8 11.9 1.5 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component CitMHS PF03600.16 ACT03683.1 - 0.0092 15.2 9.0 0.015 14.5 9.0 1.4 1 0 0 1 1 1 1 Citrate transporter Epiglycanin_C PF14654.6 ACT03683.1 - 0.055 13.5 0.2 0.14 12.2 0.2 1.6 1 0 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region Holin_SPP1 PF04688.13 ACT03683.1 - 0.13 12.5 2.5 0.21 11.8 0.3 2.5 2 0 0 2 2 2 0 SPP1 phage holin Ribosomal_S4 PF00163.19 ACT03684.1 - 0.071 14.0 0.5 0.071 14.0 0.5 1.3 1 1 0 1 1 1 0 Ribosomal protein S4/S9 N-terminal domain Oxidored_FMN PF00724.20 ACT03685.1 - 3.9e-76 256.5 0.0 4.5e-76 256.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 ACT03685.1 - 7.1e-05 22.0 0.1 0.00042 19.5 0.0 2.1 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ACT03685.1 - 0.0054 16.2 0.0 0.06 12.8 0.0 2.6 2 1 1 3 3 3 1 Histidine biosynthesis protein HTH_1 PF00126.27 ACT03686.1 - 9.1e-17 60.8 0.2 1.6e-16 60.0 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 ACT03686.1 - 1.6e-12 47.2 0.0 2.4e-12 46.7 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain F5_F8_type_C PF00754.25 ACT03687.1 - 1.8e-103 341.6 39.6 3.8e-27 94.9 2.7 5.6 5 0 0 5 5 5 4 F5/8 type C domain Glyco_hyd_65N_2 PF14498.6 ACT03687.1 - 3e-38 132.0 0.5 1.1e-37 130.2 0.5 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain SLH PF00395.20 ACT03687.1 - 6.8e-35 118.8 2.9 1.9e-12 47.0 0.2 3.8 3 0 0 3 3 3 3 S-layer homology domain fn3 PF00041.21 ACT03687.1 - 2.9e-07 30.8 10.8 5.7e-07 29.8 0.2 4.3 5 0 0 5 5 5 2 Fibronectin type III domain DUF1565 PF07602.11 ACT03687.1 - 0.001 18.4 0.0 0.001 18.4 0.0 3.6 2 1 1 3 3 3 1 Protein of unknown function (DUF1565) Pur_ac_phosph_N PF16656.5 ACT03687.1 - 8.4 7.0 13.2 10 6.8 2.1 4.6 3 1 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain Glyco_hydro_130 PF04041.13 ACT03688.1 - 3.5e-48 164.2 0.0 8.6e-39 133.3 0.0 2.1 2 0 0 2 2 2 2 beta-1,4-mannooligosaccharide phosphorylase Glyco_hydro_43 PF04616.14 ACT03688.1 - 0.0084 15.4 0.0 0.94 8.7 0.0 2.8 3 0 0 3 3 3 2 Glycosyl hydrolases family 43 BPD_transp_1 PF00528.22 ACT03689.1 - 7.4e-19 68.2 14.1 7.4e-19 68.2 14.1 2.4 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT03690.1 - 8.2e-11 42.0 13.5 8.2e-11 42.0 13.5 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_1 PF01547.25 ACT03691.1 - 1.3e-30 107.5 13.6 1.8e-30 107.0 13.6 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT03691.1 - 1.4e-27 97.3 11.5 2e-27 96.8 11.5 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein His_kinase PF06580.13 ACT03692.1 - 1e-25 89.8 0.9 3.8e-25 88.0 0.9 2.0 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACT03692.1 - 9.4e-14 51.5 0.2 1.8e-13 50.6 0.2 1.5 1 0 0 1 1 1 1 HAMP domain dCache_1 PF02743.18 ACT03692.1 - 1.7e-11 44.4 12.6 6.4e-11 42.5 12.6 2.1 1 1 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT03692.1 - 7.9e-08 32.8 2.6 1.1e-07 32.3 0.4 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT03692.1 - 0.00041 20.2 0.1 0.00094 19.0 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT03692.1 - 0.00045 20.2 0.0 0.00081 19.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 ACT03692.1 - 0.0046 16.8 0.1 0.015 15.2 0.1 1.8 1 0 0 1 1 1 1 GHKL domain sCache_3_3 PF17202.4 ACT03692.1 - 0.028 14.8 0.0 0.069 13.6 0.0 1.6 1 0 0 1 1 1 0 Single cache domain 3 sCache_3_2 PF17203.4 ACT03692.1 - 0.17 12.0 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 Single cache domain 3 VMA21 PF09446.10 ACT03692.1 - 5.2 7.3 8.5 0.65 10.1 2.9 2.3 2 1 0 2 2 2 0 VMA21-like domain Response_reg PF00072.24 ACT03693.1 - 5.7e-27 94.1 0.0 1.4e-26 92.9 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT03693.1 - 8e-20 70.9 0.0 2e-19 69.7 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03693.1 - 4.7e-12 45.7 0.0 4.1e-06 26.7 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT03693.1 - 9.3e-11 42.0 0.0 2.2e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 GGDEF-like domain IMS PF00817.20 ACT03693.1 - 0.0081 16.2 0.0 0.03 14.3 0.0 2.1 2 0 0 2 2 2 1 impB/mucB/samB family Flavodoxin_2 PF02525.17 ACT03694.1 - 1.9e-50 171.4 0.0 2.1e-50 171.2 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ACT03694.1 - 3.1e-10 40.0 0.0 3.9e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Raf1_HTH PF18579.1 ACT03694.1 - 0.15 11.8 0.1 0.85 9.4 0.2 2.2 2 1 1 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain Rrf2 PF02082.20 ACT03695.1 - 3.3e-20 72.2 1.1 1.1e-19 70.5 0.2 1.9 2 0 0 2 2 2 1 Transcriptional regulator HrcA_DNA-bdg PF03444.15 ACT03695.1 - 2.1e-05 24.1 0.1 5.4e-05 22.8 0.1 1.7 2 0 0 2 2 2 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HTH_Crp_2 PF13545.6 ACT03695.1 - 0.00019 21.3 0.2 0.00045 20.2 0.0 1.7 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_11 PF08279.12 ACT03695.1 - 0.0056 16.6 0.4 0.042 13.8 0.0 2.1 2 0 0 2 2 2 1 HTH domain TFIIE_alpha PF02002.17 ACT03695.1 - 0.0067 16.3 0.0 0.024 14.5 0.0 1.8 2 1 1 3 3 3 1 TFIIE alpha subunit MarR PF01047.22 ACT03695.1 - 0.021 14.7 0.1 0.057 13.3 0.0 1.7 2 0 0 2 2 2 0 MarR family MarR_2 PF12802.7 ACT03695.1 - 0.025 14.5 0.0 0.31 11.0 0.0 2.1 2 0 0 2 2 2 0 MarR family TrmB PF01978.19 ACT03695.1 - 0.041 13.8 0.1 0.13 12.2 0.0 1.8 2 1 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 ACT03695.1 - 0.12 11.9 0.5 0.31 10.6 0.1 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Cu_amine_oxidN1 PF07833.11 ACT03696.1 - 3.1e-18 66.1 0.0 7.8e-18 64.8 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase N-terminal domain NAD_binding_10 PF13460.6 ACT03697.1 - 1.6e-12 47.7 1.2 5.3e-11 42.7 1.2 2.2 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT03697.1 - 1.7e-09 37.6 1.6 2.2e-07 30.7 1.6 2.1 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 ACT03697.1 - 0.00013 21.5 0.5 0.00028 20.4 0.5 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ACT03697.1 - 0.00042 19.5 0.1 0.02 14.0 0.1 2.1 2 0 0 2 2 2 1 RmlD substrate binding domain DapB_N PF01113.20 ACT03697.1 - 0.003 17.7 0.8 0.0063 16.6 0.8 1.7 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 ACT03697.1 - 0.019 14.4 0.3 0.027 13.9 0.3 1.2 1 0 0 1 1 1 0 short chain dehydrogenase 3Beta_HSD PF01073.19 ACT03697.1 - 0.023 13.7 1.8 2.7 6.9 1.8 2.7 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family ELFV_dehydrog PF00208.21 ACT03697.1 - 0.067 12.9 3.3 1.9 8.1 3.3 2.5 1 1 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 ACT03697.1 - 0.11 11.9 0.1 0.23 10.8 0.1 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ACT03697.1 - 0.11 12.1 0.2 0.19 11.3 0.2 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DUF3842 PF12953.7 ACT03697.1 - 0.2 12.1 1.1 1.1 9.6 0.3 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3842) GerA PF03323.13 ACT03698.1 - 2.4e-150 501.1 0.5 3.2e-150 500.7 0.5 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_GerAC PF05504.11 ACT03699.1 - 5.7e-26 91.7 1.7 5.7e-26 91.7 1.7 2.1 3 0 0 3 3 3 1 Spore germination B3/ GerAC like, C-terminal EMP24_GP25L PF01105.24 ACT03699.1 - 0.0012 18.8 0.2 0.0025 17.8 0.2 1.4 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF1054 PF06335.12 ACT03699.1 - 0.018 15.0 0.1 0.034 14.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1054) Spore_permease PF03845.13 ACT03700.1 - 6.2e-67 225.7 40.0 8.8e-67 225.2 40.0 1.2 1 0 0 1 1 1 1 Spore germination protein Glyco_hydro_42 PF02449.15 ACT03701.1 - 1.5e-116 389.8 7.1 2e-116 389.4 7.1 1.1 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_42M PF08532.10 ACT03701.1 - 9e-38 129.9 0.0 1.4e-37 129.2 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase trimerisation domain Glyco_hydro_42C PF08533.10 ACT03701.1 - 2.6e-11 43.1 0.0 7.1e-11 41.7 0.0 1.8 1 0 0 1 1 1 1 Beta-galactosidase C-terminal domain Glyco_hydro_2_C PF02836.17 ACT03701.1 - 9.9e-06 24.9 0.0 2.1e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 ACT03701.1 - 7e-05 22.4 0.4 0.00013 21.5 0.4 1.5 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4434 PF14488.6 ACT03701.1 - 8.5e-05 22.6 1.7 0.023 14.7 1.5 4.0 3 1 0 3 3 3 1 Domain of unknown function (DUF4434) Glyco_hydro_14 PF01373.17 ACT03701.1 - 0.00024 20.2 0.2 0.00052 19.1 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 HTH_18 PF12833.7 ACT03702.1 - 4.9e-22 78.0 1.7 1.2e-21 76.7 1.7 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03702.1 - 1.2e-18 66.7 2.4 2e-08 34.1 0.3 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03702.1 - 1.7e-14 53.8 1.2 2.1e-14 53.6 0.4 1.6 2 0 0 2 2 2 1 AraC-like ligand binding domain AraC_binding_2 PF14525.6 ACT03702.1 - 0.00041 20.1 0.0 0.0008 19.1 0.0 1.6 1 1 0 1 1 1 1 AraC-binding-like domain Cupin_2 PF07883.11 ACT03702.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Cupin domain MarR PF01047.22 ACT03703.1 - 1.6e-12 47.2 0.0 9.9e-12 44.6 0.0 2.3 2 1 0 2 2 2 1 MarR family MarR_2 PF12802.7 ACT03703.1 - 1.5e-07 31.2 0.1 1.5e-07 31.2 0.1 1.6 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 ACT03703.1 - 3.9e-07 30.4 0.0 1.8e-06 28.4 0.0 2.0 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_34 PF13601.6 ACT03703.1 - 4e-07 30.1 0.0 8.8e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.6 ACT03703.1 - 0.00012 21.6 0.0 0.0004 19.9 0.0 1.9 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.10 ACT03703.1 - 0.00094 18.9 0.1 0.0016 18.2 0.1 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain FeoC PF09012.10 ACT03703.1 - 0.0062 16.6 0.0 0.68 10.0 0.0 2.4 2 0 0 2 2 2 1 FeoC like transcriptional regulator HxlR PF01638.17 ACT03703.1 - 0.021 14.7 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 HxlR-like helix-turn-helix HTH_6 PF01418.17 ACT03703.1 - 0.084 12.9 0.1 0.23 11.4 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family Arylsulfotrans PF05935.11 ACT03704.1 - 7.8e-22 77.7 0.3 1.3e-20 73.7 0.3 2.6 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotran_2 PF14269.6 ACT03704.1 - 3.1e-18 66.2 0.0 5.1e-18 65.5 0.0 1.4 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) NMT1 PF09084.11 ACT03705.1 - 1.1e-19 71.3 0.1 1.8e-19 70.6 0.1 1.3 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 ACT03705.1 - 6.6e-06 25.9 0.1 9.4e-06 25.4 0.1 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 ACT03705.1 - 0.00024 20.6 0.0 0.0035 16.8 0.0 2.6 1 1 2 3 3 3 1 Bacterial extracellular solute-binding proteins, family 3 NMT1_2 PF13379.6 ACT03705.1 - 0.029 14.1 0.2 1.6 8.4 0.0 2.5 3 0 0 3 3 3 0 NMT1-like family ABC_tran PF00005.27 ACT03706.1 - 8.5e-29 100.8 0.0 1.3e-28 100.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT03706.1 - 6.2e-07 29.5 0.1 0.018 14.9 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ACT03706.1 - 4.4e-05 23.5 0.2 8.6e-05 22.5 0.1 1.5 2 0 0 2 2 1 1 RsgA GTPase AAA_25 PF13481.6 ACT03706.1 - 0.00019 21.1 0.0 0.0048 16.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ACT03706.1 - 0.00023 21.6 0.0 0.00039 20.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ACT03706.1 - 0.0014 19.1 0.4 0.02 15.3 0.4 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ACT03706.1 - 0.0024 17.6 0.0 0.098 12.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 ACT03706.1 - 0.0025 17.8 0.1 0.084 12.8 0.1 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_23 PF13476.6 ACT03706.1 - 0.0027 18.2 0.3 0.0051 17.3 0.2 1.5 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT03706.1 - 0.0033 17.1 0.1 0.0078 15.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 ACT03706.1 - 0.0035 16.8 0.4 0.16 11.4 0.4 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT03706.1 - 0.0056 17.0 0.1 0.019 15.3 0.1 2.0 2 1 0 2 2 1 1 AAA domain AAA_28 PF13521.6 ACT03706.1 - 0.0083 16.4 0.1 0.17 12.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ACT03706.1 - 0.0092 16.4 0.0 0.075 13.4 0.0 2.3 2 0 0 2 2 2 1 RNA helicase MMR_HSR1 PF01926.23 ACT03706.1 - 0.013 15.6 0.1 0.04 14.0 0.1 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATPase_2 PF01637.18 ACT03706.1 - 0.032 14.1 0.0 0.15 12.0 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_15 PF13175.6 ACT03706.1 - 0.038 13.7 0.0 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain PIF1 PF05970.14 ACT03706.1 - 0.038 13.2 0.3 2.9 6.9 0.1 2.1 2 0 0 2 2 2 0 PIF1-like helicase AAA_24 PF13479.6 ACT03706.1 - 0.061 13.0 0.1 0.22 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ACT03706.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.6 ACT03706.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ACT03706.1 - 0.12 12.4 0.6 0.26 11.3 0.2 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 ACT03706.1 - 0.13 12.2 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 NACHT domain T2SSE PF00437.20 ACT03706.1 - 0.13 11.3 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein NTPase_1 PF03266.15 ACT03706.1 - 0.15 12.0 0.1 2.3 8.1 0.0 2.1 2 0 0 2 2 2 0 NTPase SbcCD_C PF13558.6 ACT03706.1 - 0.16 12.2 0.1 0.52 10.6 0.1 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Mg_chelatase PF01078.21 ACT03706.1 - 0.16 11.3 0.0 0.34 10.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI BPD_transp_1 PF00528.22 ACT03707.1 - 5.4e-22 78.4 18.1 5.4e-22 78.4 18.1 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Bac_rhamnosid6H PF17389.2 ACT03708.1 - 9.9e-23 80.9 0.2 1.4e-22 80.5 0.2 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain DUF608 PF04685.13 ACT03708.1 - 0.0075 15.5 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region Bac_rhamnosid PF05592.11 ACT03708.1 - 0.15 12.1 0.0 7.4 6.6 0.0 2.5 2 0 0 2 2 2 0 Bacterial alpha-L-rhamnosidase concanavalin-like domain SBP_bac_1 PF01547.25 ACT03709.1 - 1.1e-24 87.9 18.1 1.8e-24 87.3 18.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT03709.1 - 6.8e-06 25.7 0.9 0.0047 16.4 0.0 2.4 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT03710.1 - 3.3e-14 53.0 11.6 3.3e-14 53.0 11.6 1.8 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT03711.1 - 1.8e-17 63.6 16.9 1.8e-17 63.6 16.9 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF4064 PF13273.6 ACT03711.1 - 0.00093 19.4 3.2 0.00093 19.4 3.2 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF4064) CM2 PF03021.14 ACT03711.1 - 0.015 15.1 2.5 0.19 11.6 0.7 2.5 2 1 0 2 2 2 0 Influenza C virus M2 protein Sigma_reg_N PF13800.6 ACT03711.1 - 3.8 7.9 13.6 0.27 11.5 0.4 3.3 4 0 0 4 4 4 0 Sigma factor regulator N-terminal SBP_bac_1 PF01547.25 ACT03712.1 - 5.7e-35 121.8 0.2 5.7e-35 121.8 0.2 1.8 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT03712.1 - 1.4e-25 90.7 1.5 1.5e-25 90.6 0.4 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT03712.1 - 0.0049 16.3 0.0 0.011 15.2 0.0 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein 17kDa_Anti_2 PF16998.5 ACT03712.1 - 0.05 13.5 0.2 0.11 12.5 0.0 1.6 2 0 0 2 2 2 0 17 kDa outer membrane surface antigen Response_reg PF00072.24 ACT03713.1 - 5.6e-24 84.5 0.1 1.5e-23 83.1 0.1 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT03713.1 - 2.6e-18 65.6 0.1 8.4e-08 32.1 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT03713.1 - 3.4e-18 65.7 0.0 7.1e-18 64.7 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain GGDEF_2 PF17853.1 ACT03713.1 - 8.4e-06 26.0 0.0 2.7e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 GGDEF-like domain GFO_IDH_MocA PF01408.22 ACT03713.1 - 0.081 13.7 0.0 0.23 12.3 0.0 1.8 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold His_kinase PF06580.13 ACT03714.1 - 1.1e-23 83.3 1.4 1.1e-23 83.3 1.4 2.7 3 0 0 3 3 3 1 Histidine kinase HATPase_c PF02518.26 ACT03714.1 - 2.3e-07 31.3 0.1 1.1e-06 29.2 0.1 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACT03714.1 - 1.1e-05 25.4 0.3 1.1e-05 25.4 0.3 1.7 2 0 0 2 2 2 1 Cache domain HATPase_c_2 PF13581.6 ACT03714.1 - 0.041 13.9 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain NEMO PF11577.8 ACT03714.1 - 0.25 11.4 2.1 11 6.1 0.2 2.4 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO DUF5316 PF17247.2 ACT03714.1 - 0.27 11.3 5.2 0.27 11.2 2.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5316) Cys_Met_Meta_PP PF01053.20 ACT03715.1 - 1.8e-154 513.9 0.0 2e-154 513.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ACT03715.1 - 3.2e-09 36.6 0.2 9.5e-09 35.0 0.1 1.8 1 1 1 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 ACT03715.1 - 1.8e-06 27.4 0.0 2.6e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ACT03715.1 - 0.00016 20.8 0.0 0.00025 20.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V SelA PF03841.13 ACT03715.1 - 0.0073 15.3 0.1 0.3 10.0 0.1 2.1 1 1 0 1 1 1 1 L-seryl-tRNA selenium transferase Beta_elim_lyase PF01212.21 ACT03715.1 - 0.03 13.6 0.0 0.11 11.8 0.0 2.0 1 1 0 1 1 1 0 Beta-eliminating lyase PALP PF00291.25 ACT03716.1 - 2.2e-66 224.2 0.1 2.5e-66 224.1 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thi4 PF01946.17 ACT03716.1 - 0.03 13.5 0.1 0.053 12.8 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Methyltransf_25 PF13649.6 ACT03717.1 - 5.3e-16 59.1 0.0 1e-15 58.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT03717.1 - 5.1e-13 49.5 0.0 8.2e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT03717.1 - 3.6e-12 46.4 0.0 5e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT03717.1 - 3.8e-10 40.4 0.0 6.6e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 ACT03717.1 - 8.1e-06 25.1 0.0 1.1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.6 ACT03717.1 - 6.4e-05 22.8 0.0 0.00011 22.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ACT03717.1 - 0.00011 21.6 0.0 0.00034 20.0 0.0 1.7 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 ACT03717.1 - 0.0015 18.1 0.0 0.0025 17.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase small domain DREV PF05219.12 ACT03717.1 - 0.0088 15.2 0.0 0.012 14.7 0.0 1.5 1 1 0 1 1 1 1 DREV methyltransferase NodS PF05401.11 ACT03717.1 - 0.0089 15.7 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_32 PF13679.6 ACT03717.1 - 0.17 11.9 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain GDPD PF03009.17 ACT03718.1 - 1.4e-21 77.4 0.0 2e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Glyco_hydro_3_C PF01915.22 ACT03719.1 - 1.4e-54 185.2 0.0 3.7e-54 183.8 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ACT03719.1 - 1e-49 169.7 0.0 2.5e-49 168.4 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ACT03719.1 - 1.9e-24 85.5 0.2 4.2e-24 84.4 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain KSHV_K1 PF11049.8 ACT03719.1 - 0.17 11.9 0.0 0.39 10.7 0.0 1.5 1 0 0 1 1 1 0 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus PTS_EIIC PF02378.18 ACT03720.1 - 4.4e-26 91.7 33.9 4.4e-26 91.7 33.9 1.6 2 0 0 2 2 2 1 Phosphotransferase system, EIIC Vpu PF00558.19 ACT03720.1 - 0.13 12.0 0.1 0.46 10.3 0.1 1.9 1 0 0 1 1 1 0 Vpu protein Glyco_hydro_39 PF01229.17 ACT03721.1 - 1.2e-88 297.8 0.0 3.1e-88 296.5 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 39 HTH_18 PF12833.7 ACT03721.1 - 1.9e-19 69.7 0.0 5.5e-19 68.2 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT03721.1 - 1.7e-10 41.0 0.0 3.6e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT03721.1 - 4.3e-09 35.9 0.0 1e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 Cupin domain HTH_AraC PF00165.23 ACT03721.1 - 4.7e-07 29.7 0.4 0.00089 19.3 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cellulase PF00150.18 ACT03721.1 - 0.0019 17.7 0.0 0.0029 17.1 0.0 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Cupin_3 PF05899.12 ACT03721.1 - 0.0096 15.6 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF861) MannoseP_isomer PF01050.18 ACT03721.1 - 0.032 14.1 0.0 0.078 12.9 0.0 1.6 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Ectoine_synth PF06339.12 ACT03721.1 - 0.053 13.7 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Ectoine synthase SLH PF00395.20 ACT03722.1 - 4.3e-39 132.3 8.5 4.7e-15 55.3 0.3 3.3 3 0 0 3 3 3 3 S-layer homology domain Cohesin PF00963.18 ACT03722.1 - 1.3e-07 31.9 5.9 2.3e-07 31.2 5.9 1.4 1 0 0 1 1 1 1 Cohesin domain Glyco_hydro_3_C PF01915.22 ACT03723.1 - 2e-40 139.0 2.1 2e-40 139.0 2.1 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ACT03723.1 - 1.1e-21 76.8 0.1 5.1e-21 74.6 0.1 2.3 1 0 0 1 1 1 1 Fibronectin type III-like domain CBM_6 PF03422.15 ACT03723.1 - 1.8e-11 44.4 0.2 1.8e-11 44.4 0.2 3.5 3 0 0 3 3 3 1 Carbohydrate binding module (family 6) He_PIG PF05345.12 ACT03723.1 - 5.7e-11 42.4 4.0 4.8e-10 39.5 4.0 2.8 1 0 0 1 1 1 1 Putative Ig domain Cohesin PF00963.18 ACT03723.1 - 3.4e-09 37.1 1.5 3.4e-09 37.1 1.5 3.1 3 0 0 3 3 3 1 Cohesin domain Glyco_hydro_3 PF00933.21 ACT03723.1 - 1.5e-08 34.4 0.0 1.7e-07 31.0 0.0 2.4 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain Dockerin_1 PF00404.18 ACT03723.1 - 5.6e-07 29.7 4.2 1.5e-06 28.3 4.2 1.8 1 0 0 1 1 1 1 Dockerin type I domain EF-hand_5 PF13202.6 ACT03723.1 - 0.00064 19.1 0.9 0.21 11.1 0.2 2.7 2 0 0 2 2 2 2 EF hand FIVAR PF07554.13 ACT03723.1 - 0.0024 18.6 4.4 0.0024 18.6 4.4 2.8 3 0 0 3 3 2 1 FIVAR domain EF-hand_1 PF00036.32 ACT03723.1 - 0.006 16.0 0.2 0.092 12.3 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ACT03723.1 - 0.023 14.6 0.4 1 9.4 0.1 2.8 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.6 ACT03723.1 - 0.033 14.6 0.0 0.071 13.6 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair MFS_1 PF07690.16 ACT03724.1 - 1.9e-62 211.3 49.4 3.6e-49 167.6 22.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ACT03724.1 - 1.3e-16 60.5 33.5 1.4e-09 37.3 12.5 2.7 1 1 1 2 2 2 2 MFS_1 like family MFS_2 PF13347.6 ACT03724.1 - 3.3e-15 55.6 32.5 3.2e-09 35.8 11.3 2.2 1 1 1 2 2 2 2 MFS/sugar transport protein Sugar_tr PF00083.24 ACT03724.1 - 6.5e-12 45.0 9.7 6.5e-12 45.0 9.7 3.7 1 1 3 4 4 4 2 Sugar (and other) transporter MFS_3 PF05977.13 ACT03724.1 - 4.7e-10 38.5 13.0 4.7e-10 38.5 13.0 1.6 1 1 1 2 2 2 2 Transmembrane secretion effector MFS_4 PF06779.14 ACT03724.1 - 3.5e-09 36.4 24.5 4.7e-09 36.0 24.5 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB LacY_symp PF01306.19 ACT03724.1 - 4.9e-08 32.2 26.3 2.5e-07 29.9 22.8 2.0 1 1 1 2 2 2 1 LacY proton/sugar symporter MFS_5 PF05631.14 ACT03724.1 - 2.8e-06 26.5 6.4 2.8e-06 26.5 6.4 2.1 1 1 0 2 2 2 1 Sugar-tranasporters, 12 TM OATP PF03137.20 ACT03724.1 - 4.7e-05 21.9 28.0 0.04 12.2 2.1 4.2 2 2 2 4 4 4 4 Organic Anion Transporter Polypeptide (OATP) family TetR_C_5 PF08360.11 ACT03725.1 - 1e-25 90.4 0.2 1.6e-25 89.7 0.2 1.3 1 0 0 1 1 1 1 QacR-like protein, C-terminal region TetR_N PF00440.23 ACT03725.1 - 8.8e-18 63.8 0.1 1.5e-17 63.1 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_17 PF17922.1 ACT03725.1 - 5.2e-05 23.3 0.3 9.7e-05 22.4 0.1 1.6 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_C_4 PF08359.11 ACT03725.1 - 8.1e-05 22.8 0.1 0.00025 21.2 0.0 2.0 1 1 2 3 3 3 1 YsiA-like protein, C-terminal region TetR_C_11 PF16859.5 ACT03725.1 - 0.00031 21.0 0.0 0.00055 20.2 0.0 1.4 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_6 PF13977.6 ACT03725.1 - 0.0038 17.4 0.0 0.0061 16.8 0.0 1.3 1 0 0 1 1 1 1 BetI-type transcriptional repressor, C-terminal TetR_C_24 PF17932.1 ACT03725.1 - 0.0061 16.8 0.0 0.014 15.7 0.0 1.7 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain HAD_2 PF13419.6 ACT03725.1 - 0.045 13.8 0.2 0.25 11.4 0.0 2.0 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase MSP1b PF03429.13 ACT03725.1 - 0.1 10.7 0.0 0.13 10.4 0.0 1.1 1 0 0 1 1 1 0 Major surface protein 1B DUF5394 PF17372.2 ACT03725.1 - 0.11 12.1 0.1 0.11 12.1 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5394) Glyco_hydro_43 PF04616.14 ACT03726.1 - 1.7e-08 34.2 0.1 2.6e-08 33.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 ACT03726.1 - 6.2e-07 29.3 0.0 4.5e-05 23.2 0.0 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_130 PF04041.13 ACT03726.1 - 0.025 13.5 0.3 14 4.5 0.1 3.0 2 1 1 3 3 3 0 beta-1,4-mannooligosaccharide phosphorylase FmdA_AmdA PF03069.15 ACT03727.1 - 5.3e-35 121.0 0.0 6.1e-32 110.9 0.0 2.6 2 1 0 2 2 2 1 Acetamidase/Formamidase family Cu_amine_oxidN1 PF07833.11 ACT03727.1 - 3e-13 50.0 0.1 1e-12 48.4 0.1 1.9 1 0 0 1 1 1 1 Copper amine oxidase N-terminal domain TRAPPC10 PF12584.8 ACT03727.1 - 0.13 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 HTH_AsnC-type PF13404.6 ACT03728.1 - 2.1e-14 53.1 2.9 2.1e-14 53.0 0.2 2.3 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 ACT03728.1 - 3.1e-13 49.0 1.9 7.7e-13 47.8 0.6 2.2 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 ACT03728.1 - 1.3e-10 41.1 0.1 2.4e-10 40.2 0.1 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_11 PF08279.12 ACT03728.1 - 6.1e-05 22.9 0.3 0.00016 21.6 0.3 1.8 1 0 0 1 1 1 1 HTH domain HTH_Mga PF08280.11 ACT03728.1 - 0.0003 20.8 0.0 0.00052 20.0 0.0 1.4 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain MarR PF01047.22 ACT03728.1 - 0.00031 20.6 0.0 0.00062 19.6 0.0 1.5 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT03728.1 - 0.0034 17.3 0.0 0.0063 16.4 0.0 1.4 1 0 0 1 1 1 1 MarR family PCI PF01399.27 ACT03728.1 - 0.0054 17.2 0.1 0.012 16.1 0.1 1.6 1 0 0 1 1 1 1 PCI domain HTH_Crp_2 PF13545.6 ACT03728.1 - 0.015 15.3 0.2 0.042 13.8 0.1 1.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain GntR PF00392.21 ACT03728.1 - 0.031 13.9 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Rrf2 PF02082.20 ACT03728.1 - 0.043 14.2 0.2 0.43 10.9 0.0 2.1 2 0 0 2 2 2 0 Transcriptional regulator RPA_C PF08784.11 ACT03728.1 - 0.068 13.8 0.1 0.16 12.6 0.1 1.6 1 0 0 1 1 1 0 Replication protein A C terminal ANTAR PF03861.14 ACT03728.1 - 0.12 12.2 0.0 0.36 10.7 0.0 1.8 1 0 0 1 1 1 0 ANTAR domain TFIIE_beta PF02186.15 ACT03728.1 - 0.16 12.3 0.7 3.6 7.9 0.1 2.5 2 1 0 2 2 2 0 TFIIE beta subunit core domain Cation_efflux PF01545.21 ACT03729.1 - 1.3e-26 93.6 14.9 1.6e-26 93.3 14.9 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ACT03729.1 - 7.3e-08 32.4 0.0 1.8e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter ANF_receptor PF01094.28 ACT03729.1 - 0.0011 18.2 0.5 0.0016 17.6 0.5 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region GFO_IDH_MocA PF01408.22 ACT03730.1 - 6.7e-26 91.5 0.9 8.2e-26 91.2 0.2 1.5 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03730.1 - 5.5e-20 71.5 0.0 9.1e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain CoA_binding PF02629.19 ACT03730.1 - 0.00042 20.9 0.4 0.00074 20.2 0.4 1.4 1 0 0 1 1 1 1 CoA binding domain NAD_binding_3 PF03447.16 ACT03730.1 - 0.0067 17.1 0.2 0.011 16.4 0.2 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ACT03730.1 - 0.027 14.9 0.5 0.058 13.8 0.5 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DUF3553 PF12073.8 ACT03730.1 - 0.19 11.5 1.5 15 5.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3553) DeoRC PF00455.22 ACT03731.1 - 3e-48 163.8 0.0 4.3e-48 163.3 0.0 1.3 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 ACT03731.1 - 9.5e-14 50.9 0.1 1.7e-13 50.1 0.1 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain CoA_trans PF01144.23 ACT03731.1 - 7.4e-05 22.3 0.0 9.9e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Coenzyme A transferase HTH_11 PF08279.12 ACT03731.1 - 0.019 14.9 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 HTH domain GntR PF00392.21 ACT03731.1 - 0.027 14.1 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_18 PF12833.7 ACT03732.1 - 2.9e-22 78.7 0.1 6.7e-22 77.6 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT03732.1 - 3.1e-11 43.3 0.3 4.6e-10 39.5 0.1 2.1 1 1 1 2 2 2 1 AraC-like ligand binding domain HTH_AraC PF00165.23 ACT03732.1 - 4.9e-10 39.2 0.1 2e-05 24.5 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT03732.1 - 1.8e-05 24.4 0.1 3.2e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding_2 PF14525.6 ACT03732.1 - 0.0012 18.6 0.0 0.0018 18.0 0.0 1.2 1 0 0 1 1 1 1 AraC-binding-like domain Cupin_3 PF05899.12 ACT03732.1 - 0.0019 17.9 0.0 0.0046 16.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF861) HTH_26 PF13443.6 ACT03732.1 - 0.033 14.6 0.1 0.072 13.5 0.1 1.6 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain Glyco_hydro_35 PF01301.19 ACT03733.1 - 6.9e-55 186.9 0.1 1.9e-54 185.5 0.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 ACT03733.1 - 1.2e-09 38.1 0.0 6.2e-08 32.4 0.0 2.9 2 1 0 2 2 2 1 Beta-galactosidase BetaGal_dom2 PF10435.9 ACT03733.1 - 4.8e-07 29.8 0.0 7.9e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 AP_endonuc_2 PF01261.24 ACT03734.1 - 1.7e-08 34.2 0.0 3e-08 33.3 0.0 1.4 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel AP_endonuc_2 PF01261.24 ACT03735.1 - 1.7e-18 66.9 0.0 8.4e-17 61.3 0.0 2.3 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel ADH_zinc_N PF00107.26 ACT03736.1 - 1.2e-15 57.6 0.0 2.1e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ACT03736.1 - 0.00046 19.7 0.3 0.0035 16.8 0.3 2.3 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_N PF08240.12 ACT03736.1 - 0.012 15.4 0.1 0.028 14.3 0.0 1.6 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-like domain Helicase_C_2 PF13307.6 ACT03736.1 - 0.041 14.1 0.0 0.064 13.4 0.0 1.2 1 0 0 1 1 1 0 Helicase C-terminal domain 3HCDH_N PF02737.18 ACT03736.1 - 0.041 13.8 0.2 0.063 13.2 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ACT03736.1 - 0.09 12.1 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ACT03736.1 - 0.14 11.8 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 ACT03736.1 - 0.14 11.4 0.2 0.23 10.7 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 ACT03736.1 - 0.15 13.1 0.0 0.28 12.2 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase HTH_18 PF12833.7 ACT03737.1 - 3.6e-21 75.2 0.2 7.9e-21 74.1 0.2 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03737.1 - 4.1e-18 65.0 0.4 2.2e-08 34.0 0.1 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03737.1 - 9.5e-10 38.5 1.2 2.3e-09 37.2 1.2 1.7 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT03737.1 - 2e-07 30.6 0.0 3.8e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 ACT03737.1 - 0.0015 18.3 0.0 0.0025 17.6 0.0 1.3 1 0 0 1 1 1 1 Cupin MCH PF02289.16 ACT03737.1 - 0.1 11.9 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Cyclohydrolase (MCH) AAA_33 PF13671.6 ACT03738.1 - 2.2e-12 47.3 0.0 2.8e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ACT03738.1 - 1.5e-07 32.0 0.0 4.6e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ACT03738.1 - 0.00029 20.2 0.0 0.00079 18.8 0.0 1.8 1 1 0 1 1 1 1 Zeta toxin AAA_17 PF13207.6 ACT03738.1 - 0.0018 18.7 0.0 0.0047 17.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ACT03738.1 - 0.0023 18.2 0.0 0.0042 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT03738.1 - 0.0023 18.3 0.0 0.0046 17.4 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain Cytidylate_kin2 PF13189.6 ACT03738.1 - 0.0028 17.8 0.0 0.0048 17.0 0.0 1.4 1 0 0 1 1 1 1 Cytidylate kinase-like family NACHT PF05729.12 ACT03738.1 - 0.0039 17.1 0.0 0.0058 16.6 0.0 1.3 1 0 0 1 1 1 1 NACHT domain cobW PF02492.19 ACT03738.1 - 0.0086 15.7 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain SKI PF01202.22 ACT03738.1 - 0.011 15.8 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 Shikimate kinase AAA PF00004.29 ACT03738.1 - 0.012 16.0 0.0 0.018 15.5 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ACT03738.1 - 0.019 15.2 0.0 0.037 14.3 0.0 1.5 2 0 0 2 2 1 0 AAA domain NTPase_1 PF03266.15 ACT03738.1 - 0.02 14.8 0.0 0.042 13.8 0.0 1.5 2 0 0 2 2 1 0 NTPase Viral_helicase1 PF01443.18 ACT03738.1 - 0.023 14.4 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase KTI12 PF08433.10 ACT03738.1 - 0.033 13.6 0.0 0.044 13.2 0.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 APS_kinase PF01583.20 ACT03738.1 - 0.037 13.9 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase CPT PF07931.12 ACT03738.1 - 0.04 13.8 0.0 0.12 12.2 0.0 1.9 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Mg_chelatase PF01078.21 ACT03738.1 - 0.043 13.2 0.0 0.064 12.6 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 ACT03738.1 - 0.066 13.0 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain MeaB PF03308.16 ACT03738.1 - 0.067 12.2 0.1 0.16 10.9 0.0 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 ACT03738.1 - 0.071 12.3 0.0 0.098 11.8 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 ACT03738.1 - 0.075 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ACT03738.1 - 0.12 11.6 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Cytidylate_kin PF02224.18 ACT03738.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase TsaE PF02367.17 ACT03738.1 - 0.16 12.0 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE dNK PF01712.19 ACT03738.1 - 0.17 11.7 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_5 PF07728.14 ACT03738.1 - 0.19 11.7 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SRP54 PF00448.22 ACT03738.1 - 0.22 11.1 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_30 PF13604.6 ACT03738.1 - 0.23 11.2 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain DinB PF05163.12 ACT03739.1 - 2.1e-10 40.8 0.0 2.5e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 DinB family DinB_2 PF12867.7 ACT03739.1 - 7.4e-06 26.5 1.2 1e-05 26.1 1.2 1.2 1 0 0 1 1 1 1 DinB superfamily DUF664 PF04978.12 ACT03739.1 - 0.0092 16.4 0.2 0.023 15.1 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF664) ABC_membrane PF00664.23 ACT03740.1 - 2.8e-61 207.6 8.3 3.6e-61 207.2 8.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT03740.1 - 1.3e-34 119.7 0.0 2.7e-34 118.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT03740.1 - 3.4e-10 39.8 0.0 1.2e-09 38.0 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 ACT03740.1 - 0.00043 20.7 0.0 0.0028 18.1 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ACT03740.1 - 0.00098 19.5 0.1 0.0024 18.3 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT03740.1 - 0.0016 18.7 0.0 0.012 15.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ACT03740.1 - 0.0022 17.7 0.0 0.0046 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT03740.1 - 0.0078 16.1 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 ACT03740.1 - 0.011 16.3 0.0 0.026 15.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ACT03740.1 - 0.039 13.7 0.1 0.25 11.1 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.6 ACT03740.1 - 0.044 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP54 PF00448.22 ACT03740.1 - 0.047 13.3 0.0 0.086 12.5 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 ACT03740.1 - 0.066 12.8 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ACT03740.1 - 0.073 12.8 0.1 0.36 10.5 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF3584 PF12128.8 ACT03740.1 - 0.084 10.4 0.0 0.13 9.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_28 PF13521.6 ACT03740.1 - 0.2 11.9 0.2 0.67 10.2 0.1 1.9 1 1 1 2 2 2 0 AAA domain ABC_membrane_3 PF13748.6 ACT03740.1 - 0.88 8.8 6.6 0.88 8.8 1.6 2.5 2 1 0 2 2 2 0 ABC transporter transmembrane region FecCD PF01032.18 ACT03741.1 - 1.6e-95 319.7 30.4 2e-95 319.4 30.4 1.1 1 0 0 1 1 1 1 FecCD transport family FecCD PF01032.18 ACT03742.1 - 1.1e-84 284.1 31.1 1.4e-84 283.8 31.1 1.0 1 0 0 1 1 1 1 FecCD transport family Adeno_E3 PF06040.11 ACT03742.1 - 0.035 14.3 0.1 0.035 14.3 0.1 2.5 3 0 0 3 3 3 0 Adenovirus E3 protein Peripla_BP_2 PF01497.18 ACT03743.1 - 3.3e-23 82.5 1.6 6.3e-23 81.6 1.7 1.4 1 1 0 1 1 1 1 Periplasmic binding protein HTH_18 PF12833.7 ACT03744.1 - 7.4e-17 61.4 0.1 2.1e-16 59.9 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03744.1 - 4.2e-16 58.6 0.5 3.3e-07 30.2 0.1 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Peripla_BP_2 PF01497.18 ACT03744.1 - 1.2e-13 51.2 0.0 2.6e-08 33.7 0.0 2.3 2 0 0 2 2 2 2 Periplasmic binding protein LodA_N PF17990.1 ACT03744.1 - 0.084 12.8 0.2 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 L-Lysine epsilon oxidase N-terminal UPF0122 PF04297.14 ACT03744.1 - 0.098 12.9 0.1 0.29 11.4 0.1 1.7 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like Cor1 PF04803.12 ACT03744.1 - 0.58 10.4 3.4 1 9.6 3.4 1.4 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region Glyco_hydro_2_N PF02837.18 ACT03745.1 - 2.5e-22 79.6 1.6 8.6e-22 77.8 1.6 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 ACT03745.1 - 2.3e-12 46.7 0.1 7.9e-11 41.6 0.1 2.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ACT03745.1 - 2.7e-09 37.7 0.1 5.3e-09 36.7 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 ACT03745.1 - 0.00092 19.8 0.0 0.0024 18.4 0.0 1.8 1 0 0 1 1 1 1 Beta-galactosidase jelly roll domain GFO_IDH_MocA PF01408.22 ACT03746.1 - 3.8e-24 85.8 0.0 6e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03746.1 - 0.035 14.1 0.0 0.06 13.4 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain OCD_Mu_crystall PF02423.15 ACT03746.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family WYL PF13280.6 ACT03747.1 - 6.7e-35 120.7 0.1 8.8e-35 120.3 0.1 1.1 1 0 0 1 1 1 1 WYL domain HTH_11 PF08279.12 ACT03747.1 - 1.4e-12 47.4 0.0 3.9e-12 45.9 0.0 1.8 1 0 0 1 1 1 1 HTH domain HTH_DeoR PF08220.12 ACT03747.1 - 0.00079 19.1 0.0 0.002 17.8 0.0 1.7 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain PuR_N PF09182.10 ACT03747.1 - 0.0049 16.8 0.6 0.19 11.7 0.0 2.8 3 0 0 3 3 3 1 Bacterial purine repressor, N-terminal HTH_28 PF13518.6 ACT03747.1 - 0.0053 16.8 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Rrf2 PF02082.20 ACT03747.1 - 0.027 14.8 0.0 0.06 13.7 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator Mga PF05043.13 ACT03747.1 - 0.035 14.7 0.0 0.09 13.4 0.0 1.6 1 0 0 1 1 1 0 Mga helix-turn-helix domain EamA PF00892.20 ACT03748.1 - 8.6e-24 84.3 38.8 1.6e-12 47.7 17.5 2.0 2 0 0 2 2 2 2 EamA-like transporter family Sugar_transport PF06800.12 ACT03748.1 - 0.00017 21.0 6.8 0.00017 21.0 6.8 2.3 3 0 0 3 3 3 1 Sugar transport protein TMEM234 PF10639.9 ACT03748.1 - 0.02 14.9 5.0 0.075 13.1 0.7 2.6 2 0 0 2 2 2 0 Putative transmembrane family 234 Peptidase_S9 PF00326.21 ACT03749.1 - 1.5e-10 40.9 0.0 2.5e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ACT03749.1 - 7.8e-09 35.1 1.3 6.9e-06 25.5 0.4 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ACT03749.1 - 1e-07 32.8 1.6 4.4e-07 30.7 0.9 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.18 ACT03749.1 - 1.3e-07 31.4 0.6 5.7e-07 29.3 0.6 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 ACT03749.1 - 2.6e-06 27.5 0.0 5.1e-06 26.6 0.0 1.6 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 ACT03749.1 - 9.5e-05 22.3 2.4 0.035 13.9 0.0 3.1 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.7 ACT03749.1 - 0.0012 18.7 0.3 3 7.6 0.0 2.9 3 0 0 3 3 3 2 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 ACT03749.1 - 0.0018 17.2 0.1 0.003 16.5 0.1 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_1 PF00561.20 ACT03749.1 - 0.0044 16.7 1.7 0.11 12.1 1.6 2.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold UPF0227 PF05728.12 ACT03749.1 - 0.0058 16.6 0.0 0.0081 16.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Chlorophyllase PF07224.11 ACT03749.1 - 0.014 14.5 0.1 0.022 13.8 0.1 1.3 1 0 0 1 1 1 0 Chlorophyllase FSH1 PF03959.13 ACT03749.1 - 0.086 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) PGAP1 PF07819.13 ACT03749.1 - 0.11 12.2 0.2 0.18 11.5 0.2 1.2 1 0 0 1 1 1 0 PGAP1-like protein DUF676 PF05057.14 ACT03749.1 - 0.16 11.5 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Peptidase_S15 PF02129.18 ACT03749.1 - 0.17 11.5 0.1 0.26 10.8 0.1 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Aldolase PF01081.19 ACT03750.1 - 5.2e-41 140.2 0.2 7e-41 139.8 0.2 1.0 1 0 0 1 1 1 1 KDPG and KHG aldolase TMP-TENI PF02581.17 ACT03750.1 - 0.00014 21.2 0.2 0.0026 17.1 0.1 2.3 2 0 0 2 2 2 1 Thiamine monophosphate synthase NMO PF03060.15 ACT03750.1 - 0.00052 19.5 0.9 0.00052 19.5 0.9 1.8 1 1 0 2 2 2 1 Nitronate monooxygenase IMPDH PF00478.25 ACT03750.1 - 0.0084 15.1 1.3 1.5 7.8 0.1 3.0 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain TT1725 PF18324.1 ACT03750.1 - 0.032 14.3 0.1 0.35 11.0 0.0 2.3 1 1 1 2 2 2 0 Hypothetical protein TT1725 QRPTase_C PF01729.19 ACT03750.1 - 0.052 13.3 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain FlpD PF02662.16 ACT03750.1 - 0.091 12.8 0.0 0.46 10.5 0.0 2.2 1 1 1 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit DHO_dh PF01180.21 ACT03750.1 - 0.1 11.8 0.1 0.25 10.5 0.1 1.5 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase FMN_dh PF01070.18 ACT03750.1 - 0.13 11.3 2.4 3 6.8 1.8 2.7 1 1 0 1 1 1 0 FMN-dependent dehydrogenase Ribul_P_3_epim PF00834.19 ACT03750.1 - 0.27 10.6 1.2 1.5 8.2 0.0 2.3 3 0 0 3 3 3 0 Ribulose-phosphate 3 epimerase family HhH-GPD PF00730.25 ACT03751.1 - 2.7e-21 76.1 0.0 6.1e-21 74.9 0.0 1.6 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 ACT03751.1 - 7.2e-19 67.8 0.1 1.5e-18 66.7 0.1 1.6 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.23 ACT03751.1 - 0.014 15.2 0.1 0.039 13.8 0.1 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 ACT03751.1 - 1.5 9.3 6.3 2.6 8.5 6.3 1.4 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III HTH_18 PF12833.7 ACT03752.1 - 4.6e-18 65.3 0.1 6.4e-15 55.2 0.0 2.2 1 1 1 2 2 2 2 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03752.1 - 1.1e-17 63.6 0.0 2e-09 37.3 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03752.1 - 0.00011 22.1 0.0 0.00018 21.4 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain AraC_binding_2 PF14525.6 ACT03752.1 - 0.21 11.2 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 AraC-binding-like domain Cytochrome_CBB3 PF13442.6 ACT03753.1 - 6.3e-14 52.0 0.0 8.7e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 ACT03753.1 - 2.4e-08 35.0 0.2 1.9e-06 28.9 0.2 2.1 1 1 0 1 1 1 1 Cytochrome c ACPS PF01648.20 ACT03754.1 - 2.9e-17 62.8 0.0 3.3e-17 62.6 0.0 1.1 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 ACT03754.1 - 5.8e-05 23.1 0.7 0.0024 17.9 0.1 2.3 2 1 0 2 2 2 2 4'-phosphopantetheinyl transferase N-terminal domain NAD_synthase PF02540.17 ACT03755.1 - 6.4e-60 202.3 0.0 8e-60 202.0 0.0 1.1 1 0 0 1 1 1 1 NAD synthase SMC_hinge PF06470.13 ACT03755.1 - 0.039 14.3 0.1 0.23 11.7 0.0 2.1 1 1 1 2 2 2 0 SMC proteins Flexible Hinge Domain QueC PF06508.13 ACT03755.1 - 0.054 13.0 0.0 3.2 7.2 0.0 2.3 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 ACT03755.1 - 0.062 12.1 0.0 1.2 7.9 0.0 2.1 2 0 0 2 2 2 0 tRNA methyl transferase Disulph_isomer PF06491.11 ACT03756.1 - 2.3e-65 218.8 0.0 2.6e-65 218.6 0.0 1.0 1 0 0 1 1 1 1 Disulphide isomerase DUF3905 PF13045.6 ACT03757.1 - 1.5e-40 137.1 0.8 2e-40 136.7 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3905) HATPase_c PF02518.26 ACT03759.1 - 2.6e-20 73.0 0.3 5.6e-20 71.9 0.3 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT03759.1 - 1.5e-14 53.8 0.1 4.5e-14 52.2 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 ACT03759.1 - 0.0001 22.2 0.1 0.00026 20.9 0.1 1.7 1 0 0 1 1 1 1 GHKL domain 5TM-5TMR_LYT PF07694.12 ACT03759.1 - 0.00011 21.8 12.2 0.00018 21.0 12.2 1.3 1 0 0 1 1 1 1 5TMR of 5TMR-LYT PAS_9 PF13426.7 ACT03759.1 - 0.00012 22.3 0.1 0.00027 21.1 0.1 1.6 1 0 0 1 1 1 1 PAS domain PAS_10 PF13596.6 ACT03759.1 - 0.014 16.0 0.1 0.028 15.0 0.1 1.5 1 0 0 1 1 1 0 PAS domain DUF1345 PF07077.11 ACT03759.1 - 0.015 15.0 2.6 0.026 14.2 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) PAS_8 PF13188.7 ACT03759.1 - 0.073 13.1 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 PAS domain DUF1129 PF06570.11 ACT03759.1 - 0.088 12.3 7.7 0.18 11.3 7.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) CCDC24 PF15669.5 ACT03759.1 - 0.095 12.6 0.5 0.21 11.5 0.5 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family PAS PF00989.25 ACT03759.1 - 0.11 12.5 0.0 0.29 11.1 0.0 1.9 1 1 0 1 1 1 0 PAS fold HATPase_c_3 PF13589.6 ACT03759.1 - 0.15 11.8 0.2 0.41 10.5 0.0 1.7 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF5413 PF17434.2 ACT03759.1 - 0.67 10.3 7.1 2.2 8.6 7.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5413) 7TMR-DISM_7TM PF07695.11 ACT03759.1 - 3.2 7.6 21.9 0.66 9.8 13.2 2.2 1 1 1 2 2 2 0 7TM diverse intracellular signalling ABC2_membrane_5 PF13346.6 ACT03759.1 - 7.6 6.0 21.4 36 3.8 21.4 2.0 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF3792 PF12670.7 ACT03759.1 - 8 6.7 13.1 21 5.3 9.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3792) Hydrolase_4 PF12146.8 ACT03760.1 - 3.9e-67 226.0 0.1 4.8e-67 225.7 0.1 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ACT03760.1 - 3.3e-11 44.2 1.0 4.5e-11 43.8 1.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ACT03760.1 - 2.6e-10 40.4 0.1 1.7e-07 31.1 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ACT03760.1 - 3.6e-07 30.2 0.1 0.035 13.9 0.0 3.1 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.7 ACT03760.1 - 1.5e-06 28.1 0.0 0.16 11.7 0.0 3.1 3 0 0 3 3 3 2 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 ACT03760.1 - 4.1e-05 23.5 0.1 0.0002 21.3 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 ACT03760.1 - 4.4e-05 23.5 0.1 0.00044 20.3 0.0 2.1 2 0 0 2 2 2 1 TAP-like protein Thioesterase PF00975.20 ACT03760.1 - 0.00018 21.7 0.1 0.00027 21.1 0.1 1.2 1 0 0 1 1 1 1 Thioesterase domain BAAT_C PF08840.11 ACT03760.1 - 0.00054 19.9 0.0 0.00092 19.2 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 ACT03760.1 - 0.0017 18.0 0.1 2.4 7.6 0.0 2.8 2 1 0 2 2 2 2 Dienelactone hydrolase family Ser_hydrolase PF06821.13 ACT03760.1 - 0.0025 17.7 0.0 0.56 10.0 0.0 2.3 2 0 0 2 2 2 1 Serine hydrolase FSH1 PF03959.13 ACT03760.1 - 0.0027 17.4 0.0 0.0055 16.4 0.0 1.5 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Esterase PF00756.20 ACT03760.1 - 0.013 15.1 0.0 0.053 13.2 0.0 1.8 2 0 0 2 2 2 0 Putative esterase Chlorophyllase2 PF12740.7 ACT03760.1 - 0.016 14.2 0.0 0.029 13.3 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF2974 PF11187.8 ACT03760.1 - 0.075 12.6 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PGAP1 PF07819.13 ACT03760.1 - 0.081 12.6 0.0 0.39 10.4 0.0 2.0 2 0 0 2 2 2 0 PGAP1-like protein Acyl_transf_2 PF02273.15 ACT03760.1 - 0.089 12.0 0.1 0.47 9.6 0.0 1.8 2 0 0 2 2 2 0 Acyl transferase DUF1350 PF07082.11 ACT03760.1 - 0.094 12.0 0.0 4.5 6.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1350) Peptidase_S9 PF00326.21 ACT03760.1 - 0.095 12.2 0.3 0.82 9.1 0.0 2.5 3 0 0 3 3 3 0 Prolyl oligopeptidase family Lipase_3 PF01764.25 ACT03760.1 - 0.16 11.9 0.1 0.26 11.1 0.1 1.3 1 0 0 1 1 1 0 Lipase (class 3) PAF-AH_p_II PF03403.13 ACT03760.1 - 0.17 10.4 0.5 0.73 8.3 0.1 2.0 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase PF07224.11 ACT03760.1 - 0.17 10.9 0.0 0.45 9.5 0.0 1.6 1 1 0 1 1 1 0 Chlorophyllase HI0933_like PF03486.14 ACT03761.1 - 1.3e-146 488.5 0.1 1.5e-146 488.3 0.1 1.0 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 ACT03761.1 - 5.5e-18 65.2 3.3 2.2e-09 36.9 0.2 3.1 3 0 0 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 ACT03761.1 - 3.4e-13 49.7 0.4 3.4e-13 49.7 0.4 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 ACT03761.1 - 9.8e-12 44.6 12.5 4.7e-09 35.8 6.2 2.6 2 1 0 2 2 2 2 Glucose inhibited division protein A DAO PF01266.24 ACT03761.1 - 1.9e-10 40.9 4.5 6.4e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ACT03761.1 - 1.6e-09 37.4 0.7 5.1e-09 35.8 0.3 1.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACT03761.1 - 2.1e-08 33.8 2.2 0.0019 17.6 2.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT03761.1 - 1.4e-07 32.0 2.6 0.0036 17.8 0.4 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ACT03761.1 - 5.1e-06 26.0 1.1 1.1e-05 24.8 1.1 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ACT03761.1 - 1.2e-05 25.4 3.5 0.00023 21.3 2.6 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 ACT03761.1 - 9.2e-05 21.5 0.4 0.19 10.6 0.1 2.4 2 0 0 2 2 2 2 Tryptophan halogenase Thi4 PF01946.17 ACT03761.1 - 0.00027 20.2 2.6 0.052 12.8 0.9 2.4 2 0 0 2 2 2 2 Thi4 family Amino_oxidase PF01593.24 ACT03761.1 - 0.0022 17.4 0.4 0.0047 16.3 0.0 1.7 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase AlaDh_PNT_C PF01262.21 ACT03761.1 - 0.0031 16.8 0.1 0.0068 15.7 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 ACT03761.1 - 0.042 12.9 3.6 0.12 11.4 1.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Ntox50 PF15542.6 ACT03761.1 - 0.12 13.1 0.0 0.74 10.7 0.0 2.1 1 1 1 2 2 2 0 Bacterial toxin 50 NAD_binding_9 PF13454.6 ACT03761.1 - 0.46 10.5 3.2 9.8 6.1 0.7 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding Glyoxalase_6 PF18029.1 ACT03762.1 - 0.034 14.9 0.0 0.058 14.2 0.0 1.4 1 0 0 1 1 1 0 Glyoxalase-like domain PAS_9 PF13426.7 ACT03763.1 - 2.3e-10 40.6 0.0 1e-06 28.9 0.0 2.3 2 0 0 2 2 2 2 PAS domain HTH_26 PF13443.6 ACT03763.1 - 3.2e-07 30.7 0.3 7.3e-07 29.5 0.3 1.6 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_3 PF01381.22 ACT03763.1 - 1.4e-05 25.0 0.7 2.7e-05 24.2 0.7 1.5 1 0 0 1 1 1 1 Helix-turn-helix PAS PF00989.25 ACT03763.1 - 0.0047 16.9 0.0 0.65 10.0 0.0 2.6 2 1 0 2 2 2 1 PAS fold HTH_11 PF08279.12 ACT03763.1 - 0.012 15.5 0.5 1.1 9.2 0.6 2.6 2 0 0 2 2 2 0 HTH domain HTH_19 PF12844.7 ACT03763.1 - 0.024 14.6 0.1 0.098 12.7 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_35 PF13693.6 ACT03763.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TatC PF00902.18 ACT03764.1 - 1.3e-50 172.1 15.7 1.6e-50 171.9 15.7 1.1 1 0 0 1 1 1 1 Sec-independent protein translocase protein (TatC) Renin_r PF07850.14 ACT03764.1 - 2.8 8.6 6.2 2.2 8.9 0.7 2.6 2 0 0 2 2 2 0 Renin receptor-like protein MerR_1 PF13411.6 ACT03765.1 - 1.5e-15 57.0 0.0 1.7e-15 56.9 0.0 1.0 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT03765.1 - 4.4e-12 45.6 0.4 5.9e-12 45.2 0.4 1.2 1 0 0 1 1 1 1 MerR family regulatory protein Amino_oxidase PF01593.24 ACT03766.1 - 3.7e-54 184.7 0.0 5.5e-54 184.2 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ACT03766.1 - 2e-10 40.7 0.2 6.9e-10 39.0 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ACT03766.1 - 5.2e-08 32.5 0.2 0.00056 19.3 0.2 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 ACT03766.1 - 4.6e-07 29.7 0.3 5.5e-06 26.2 0.5 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ACT03766.1 - 1.5e-06 27.7 0.2 5.6e-05 22.5 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ACT03766.1 - 2.5e-06 26.9 0.3 4.3e-06 26.2 0.3 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 ACT03766.1 - 6e-06 25.6 0.5 8.9e-06 25.0 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ACT03766.1 - 0.002 16.9 0.4 0.0033 16.2 0.4 1.3 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 ACT03766.1 - 0.0028 17.0 0.1 0.0058 15.9 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 ACT03766.1 - 0.0093 16.5 0.8 0.088 13.4 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACT03766.1 - 0.01 15.1 0.8 0.04 13.2 0.1 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ACT03766.1 - 0.011 14.9 0.7 0.019 14.1 0.7 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 ACT03766.1 - 0.051 12.9 1.7 0.078 12.3 1.7 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ACT03766.1 - 0.12 11.4 0.2 0.17 10.9 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Ribonuc_L-PSP PF01042.21 ACT03767.1 - 2.7e-14 53.2 0.0 3.9e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Endoribonuclease L-PSP MttA_Hcf106 PF02416.16 ACT03768.1 - 3.8e-20 70.9 0.1 4.5e-20 70.7 0.1 1.0 1 0 0 1 1 1 1 mttA/Hcf106 family FGGY_N PF00370.21 ACT03769.1 - 3.8e-70 236.2 0.0 5.2e-70 235.8 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ACT03769.1 - 6.1e-33 114.2 0.0 1.1e-32 113.4 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 ACT03769.1 - 3.8e-06 26.6 0.1 0.00014 21.4 0.0 2.3 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family AP_endonuc_2 PF01261.24 ACT03770.1 - 0.00024 20.6 0.1 0.0018 17.8 0.0 2.0 1 1 1 2 2 2 1 Xylose isomerase-like TIM barrel HTH_3 PF01381.22 ACT03771.1 - 0.028 14.5 0.0 0.033 14.3 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix HTH_25 PF13413.6 ACT03771.1 - 0.067 13.1 0.0 0.078 12.9 0.0 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_19 PF12844.7 ACT03771.1 - 0.1 12.6 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_31 PF13560.6 ACT03771.1 - 0.11 12.9 0.0 0.12 12.7 0.0 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain Glyco_hydro_25 PF01183.20 ACT03772.1 - 4.1e-49 167.2 0.3 1.5e-48 165.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 25 XhlA PF10779.9 ACT03774.1 - 5.8e-20 71.3 0.4 6.5e-20 71.1 0.4 1.0 1 0 0 1 1 1 1 Haemolysin XhlA DUF4525 PF15027.6 ACT03774.1 - 0.015 15.0 0.1 0.018 14.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) ThrE PF06738.12 ACT03774.1 - 0.031 13.6 0.0 0.031 13.6 0.0 1.1 1 0 0 1 1 1 0 Putative threonine/serine exporter Lentiviral_Tat PF02998.14 ACT03774.1 - 0.091 12.8 0.2 0.19 11.8 0.1 1.5 1 1 1 2 2 2 0 Lentiviral Tat protein Kelch_4 PF13418.6 ACT03775.1 - 0.043 13.8 0.9 4.1 7.5 0.1 2.9 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ACT03775.1 - 0.066 13.5 3.7 0.39 11.1 0.1 3.2 2 1 1 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ACT03775.1 - 0.12 12.7 3.5 16 5.9 0.1 4.1 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ACT03775.1 - 2.6 7.7 6.3 6.1 6.5 0.0 3.4 4 0 0 4 4 4 0 Kelch motif DUF2313 PF10076.9 ACT03776.1 - 4.8e-37 127.3 0.0 5.6e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein conserved in bacteria (DUF2313) Phage_fiber_2 PF03406.13 ACT03777.1 - 8.6e-14 50.8 4.2 8.6e-14 50.8 4.2 1.6 2 0 0 2 2 2 1 Phage tail fibre repeat Mtd_N PF18454.1 ACT03777.1 - 2.9e-11 43.2 0.6 5.4e-11 42.3 0.0 1.8 2 0 0 2 2 2 1 Major tropism determinant N-terminal domain EF-hand_1 PF00036.32 ACT03777.1 - 0.15 11.7 0.5 0.26 10.9 0.5 1.4 1 0 0 1 1 1 0 EF hand DUF2793 PF10983.8 ACT03778.1 - 3.2e-23 81.4 5.9 1.6e-22 79.2 4.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2793) Mtd_N PF18454.1 ACT03778.1 - 2.8e-17 62.4 0.0 1.1e-16 60.6 0.0 2.1 1 0 0 1 1 1 1 Major tropism determinant N-terminal domain Av_adeno_fibre PF06536.11 ACT03778.1 - 0.077 12.9 1.3 9.2 6.2 0.4 3.1 2 1 0 2 2 2 0 Avian adenovirus fibre, N-terminal Baseplate_J PF04865.14 ACT03780.1 - 2.9e-58 197.0 0.0 3.8e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Baseplate J-like protein NMT1 PF09084.11 ACT03780.1 - 0.049 13.6 0.0 5.9 6.8 0.0 2.2 2 0 0 2 2 2 0 NMT1/THI5 like DUF2634 PF10934.8 ACT03781.1 - 4.2e-19 68.6 0.1 1e-18 67.4 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2634) DUF2577 PF10844.8 ACT03782.1 - 1.1e-14 54.5 0.0 2e-09 37.6 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF2577) LysM PF01476.20 ACT03784.1 - 1.2e-07 31.7 0.0 2.4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 LysM domain APG17 PF04108.12 ACT03785.1 - 0.0017 17.5 2.5 0.0037 16.4 2.5 1.5 1 0 0 1 1 1 1 Autophagy protein Apg17 Sec8_exocyst PF04048.14 ACT03785.1 - 0.0059 16.5 4.3 0.023 14.6 4.0 2.3 1 1 0 1 1 1 1 Sec8 exocyst complex component specific domain COG6 PF06419.11 ACT03785.1 - 0.011 14.0 3.8 0.024 12.9 3.8 1.5 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Lipoprotein_6 PF01441.19 ACT03785.1 - 0.028 14.5 4.2 0.084 12.9 3.8 2.0 1 1 1 2 2 2 0 Lipoprotein HOASN PF14515.6 ACT03785.1 - 0.035 14.5 0.3 0.11 12.9 0.3 1.9 1 0 0 1 1 1 0 Haem-oxygenase-associated N-terminal helices V-ATPase_C PF03223.15 ACT03785.1 - 0.063 12.7 0.7 0.12 11.8 0.7 1.4 1 0 0 1 1 1 0 V-ATPase subunit C DUF1400 PF07176.11 ACT03785.1 - 0.081 13.2 3.4 0.33 11.2 0.0 2.9 2 1 1 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF1400) DUF948 PF06103.11 ACT03785.1 - 0.17 12.1 13.7 0.63 10.3 6.2 4.4 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 ACT03785.1 - 0.38 11.1 11.5 8.3 6.8 0.0 3.7 3 1 1 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 ACT03785.1 - 0.54 10.3 6.4 2.1 8.4 1.2 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Kinesin_assoc PF16183.5 ACT03785.1 - 1 9.5 5.7 18 5.4 0.1 2.6 2 1 0 2 2 2 0 Kinesin-associated G0-G1_switch_2 PF15103.6 ACT03785.1 - 1.2 9.5 3.1 7.8 7.0 0.0 3.3 3 1 0 3 3 2 0 G0/G1 switch protein 2 IFT57 PF10498.9 ACT03785.1 - 1.6 7.6 9.3 0.066 12.2 3.1 1.8 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Peptidase_S49_N PF08496.10 ACT03785.1 - 2.7 8.0 6.0 2.3 8.2 0.2 2.7 3 0 0 3 3 3 0 Peptidase family S49 N-terminal SLATT_6 PF18169.1 ACT03785.1 - 3.1 7.4 6.4 2 8.0 0.4 2.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 LOH1CR12 PF10158.9 ACT03785.1 - 6.1 6.9 6.9 11 6.0 0.8 3.4 3 0 0 3 3 2 0 Tumour suppressor protein Phage_TAC_5 PF08890.11 ACT03786.1 - 1.7e-38 131.7 0.4 1.9e-38 131.5 0.4 1.0 1 0 0 1 1 1 1 Phage XkdN-like tail assembly chaperone protein, TAC Phage_TAC_4 PF08748.11 ACT03786.1 - 0.02 15.2 0.1 0.039 14.3 0.1 1.4 1 1 0 1 1 1 0 Phage tail assembly chaperone DUF2001 PF09393.10 ACT03787.1 - 4.3e-46 156.4 0.0 4.7e-46 156.2 0.0 1.0 1 0 0 1 1 1 1 Phage tail tube protein Phage_sheath_1 PF04984.14 ACT03788.1 - 1.2e-35 122.9 5.0 2.7e-35 121.7 5.0 1.6 1 0 0 1 1 1 1 Phage tail sheath protein subtilisin-like domain Phage_sheath_1C PF17482.2 ACT03788.1 - 2.4e-24 85.3 0.8 5.3e-24 84.2 0.8 1.6 1 0 0 1 1 1 1 Phage tail sheath C-terminal domain Phage_sheath_1N PF17481.2 ACT03788.1 - 1e-14 54.9 5.3 1e-14 54.9 5.3 3.1 2 1 0 2 2 2 1 Phage tail sheath protein beta-sandwich domain DUF2789 PF10982.8 ACT03789.1 - 0.08 13.1 0.0 0.31 11.2 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2789) Sigma70_ECF PF07638.11 ACT03791.1 - 2.8e-05 24.1 0.1 4.7e-05 23.3 0.1 1.6 1 1 0 1 1 1 1 ECF sigma factor Sigma70_r4_2 PF08281.12 ACT03791.1 - 0.00066 19.3 0.1 0.0017 18.0 0.1 1.8 1 0 0 1 1 1 1 Sigma-70, region 4 DUF4477 PF14780.6 ACT03791.1 - 0.012 15.3 0.8 0.021 14.4 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4477) HTH_28 PF13518.6 ACT03791.1 - 0.014 15.5 0.1 0.096 12.8 0.2 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain DUF2730 PF10805.8 ACT03791.1 - 0.022 14.8 2.5 0.25 11.5 0.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) HTH_Tnp_1 PF01527.20 ACT03791.1 - 0.029 14.7 1.7 0.1 12.9 0.1 2.7 3 1 1 4 4 4 0 Transposase OmpH PF03938.14 ACT03791.1 - 0.052 13.9 4.4 0.13 12.6 4.4 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Peroxin-13_N PF04088.13 ACT03791.1 - 0.11 12.7 0.0 0.28 11.5 0.0 1.7 1 1 1 2 2 2 0 Peroxin 13, N-terminal region BESS PF02944.20 ACT03791.1 - 0.12 12.3 3.7 0.89 9.4 0.1 2.7 3 0 0 3 3 3 0 BESS motif HTH_23 PF13384.6 ACT03791.1 - 0.17 11.7 3.7 0.31 10.9 0.2 3.0 3 1 1 4 4 4 0 Homeodomain-like domain Cortex-I_coil PF09304.10 ACT03791.1 - 1.1 9.5 7.5 0.12 12.6 2.3 2.2 2 1 1 3 3 3 0 Cortexillin I, coiled coil FlxA PF14282.6 ACT03791.1 - 4.2 7.4 9.3 4.3 7.4 1.3 2.5 2 0 0 2 2 2 0 FlxA-like protein HSCB_C PF07743.13 ACT03791.1 - 5 7.7 8.3 0.32 11.5 1.3 2.6 3 1 0 3 3 3 0 HSCB C-terminal oligomerisation domain HTH_3 PF01381.22 ACT03792.1 - 4.2e-13 49.1 0.1 6.9e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 ACT03792.1 - 1.5e-08 34.5 0.1 3.1e-08 33.5 0.1 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ACT03792.1 - 1.6e-07 31.6 0.0 1.9e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain MqsA_antitoxin PF15731.5 ACT03792.1 - 0.00069 19.7 0.0 0.0012 19.0 0.0 1.5 2 0 0 2 2 2 1 Antitoxin component of bacterial toxin-antitoxin system, MqsA FAM193_C PF15914.5 ACT03792.1 - 0.0012 18.5 0.4 0.0028 17.4 0.2 1.8 2 0 0 2 2 2 1 FAM193 family C-terminal HTH_26 PF13443.6 ACT03792.1 - 0.0022 18.4 0.0 0.0031 17.9 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain YdaS_antitoxin PF15943.5 ACT03792.1 - 0.01 15.7 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Phage_CI_repr PF07022.13 ACT03792.1 - 0.011 15.7 0.0 0.048 13.8 0.0 1.8 2 0 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT03792.1 - 0.013 15.5 0.0 0.046 13.7 0.0 2.0 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_37 PF13744.6 ACT03792.1 - 0.034 14.1 0.1 0.096 12.6 0.0 1.9 2 1 1 3 3 3 0 Helix-turn-helix domain DUF4447 PF14590.6 ACT03792.1 - 0.046 13.5 0.0 0.054 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4447) P22_Cro PF14549.6 ACT03792.1 - 0.046 13.6 0.2 0.11 12.4 0.2 1.6 1 1 0 1 1 1 0 DNA-binding transcriptional regulator Cro Sigma70_r4 PF04545.16 ACT03792.1 - 0.056 13.0 0.0 0.49 10.0 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 LysM PF01476.20 ACT03792.1 - 0.072 13.2 0.1 1.8 8.7 0.0 2.3 2 0 0 2 2 2 0 LysM domain HTH_10 PF04967.12 ACT03792.1 - 0.072 12.9 0.0 5.5 6.9 0.0 2.3 2 0 0 2 2 2 0 HTH DNA binding domain MarR PF01047.22 ACT03792.1 - 0.099 12.6 0.0 2.5 8.1 0.0 2.2 1 1 1 2 2 2 0 MarR family Glycos_trans_3N PF02885.17 ACT03792.1 - 0.2 11.5 0.5 2.4 8.0 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain ROK PF00480.20 ACT03793.1 - 3.3e-70 236.9 0.1 4.1e-70 236.6 0.1 1.1 1 0 0 1 1 1 1 ROK family HTH_IclR PF09339.10 ACT03793.1 - 0.00016 21.4 0.0 0.00033 20.4 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.6 ACT03793.1 - 0.00017 21.1 0.1 0.00037 20.0 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ACT03793.1 - 0.00028 20.7 0.0 0.00061 19.6 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 ACT03793.1 - 0.0062 16.5 0.0 0.018 15.0 0.0 1.7 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain TrmB PF01978.19 ACT03793.1 - 0.012 15.4 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB FGGY_N PF00370.21 ACT03793.1 - 0.017 14.7 0.0 0.038 13.5 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Phage_rep_O PF04492.13 ACT03793.1 - 0.031 14.9 0.0 0.35 11.5 0.0 2.3 2 0 0 2 2 2 0 Bacteriophage replication protein O SMC_ScpB PF04079.16 ACT03793.1 - 0.048 13.3 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB BcrAD_BadFG PF01869.20 ACT03793.1 - 0.061 12.8 0.0 0.35 10.3 0.0 2.0 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family HTH_5 PF01022.20 ACT03793.1 - 0.078 12.9 0.1 0.2 11.5 0.1 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family OrfB_IS605 PF01385.19 ACT03793.1 - 0.15 12.3 0.0 5.1 7.4 0.0 2.5 2 0 0 2 2 2 0 Probable transposase TFIIE_alpha PF02002.17 ACT03793.1 - 0.54 10.1 1.7 1.4 8.8 0.4 2.2 2 0 0 2 2 2 0 TFIIE alpha subunit DUF4625 PF15418.6 ACT03794.1 - 0.019 15.2 1.2 15 5.8 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4625) DUF3244 PF11589.8 ACT03794.1 - 0.31 11.1 1.7 1.5 8.9 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3244) SLH PF00395.20 ACT03795.1 - 2.8e-17 62.5 8.7 4.4e-17 61.8 0.0 4.0 4 1 0 4 4 4 2 S-layer homology domain Cellulase PF00150.18 ACT03796.1 - 9e-37 127.0 6.5 1.4e-36 126.4 6.5 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4038 PF13204.6 ACT03796.1 - 0.015 15.0 0.3 0.021 14.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) LAL_C2 PF18603.1 ACT03796.1 - 0.15 12.3 0.4 0.49 10.6 0.1 2.0 2 0 0 2 2 2 0 L-amino acid ligase C-terminal domain 2 MFS_1 PF07690.16 ACT03797.1 - 1e-35 123.3 45.7 1e-35 123.3 45.7 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 ACT03797.1 - 3e-12 45.9 19.9 4.3e-12 45.3 19.9 1.2 1 0 0 1 1 1 1 MFS/sugar transport protein Sugar_tr PF00083.24 ACT03797.1 - 0.11 11.3 33.9 0.037 12.9 15.9 3.3 2 2 2 4 4 4 0 Sugar (and other) transporter OATP PF03137.20 ACT03797.1 - 5.3 5.2 15.4 0.016 13.5 1.9 2.5 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Lactonase PF10282.9 ACT03798.1 - 8.8e-109 363.9 0.1 9.9e-109 363.7 0.1 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller DUF1513 PF07433.11 ACT03798.1 - 0.014 14.5 0.2 0.52 9.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) LytTR PF04397.15 ACT03799.1 - 1.2e-05 25.5 0.0 1.5e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 LytTr DNA-binding domain Aldose_epim PF01263.20 ACT03800.1 - 1.1e-37 129.9 0.1 1.4e-37 129.6 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase SUFU PF05076.13 ACT03801.1 - 5.5e-44 150.2 0.0 6.4e-44 150.0 0.0 1.0 1 0 0 1 1 1 1 Suppressor of fused protein (SUFU) OCD_Mu_crystall PF02423.15 ACT03802.1 - 8.2e-31 107.1 0.0 2e-29 102.6 0.0 2.0 2 0 0 2 2 2 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 ACT03802.1 - 0.0044 17.1 0.0 0.0082 16.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 ACT03802.1 - 0.0057 16.8 0.0 0.0086 16.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase PALP PF00291.25 ACT03803.1 - 7e-54 183.2 0.0 8e-54 183.0 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme AMP-binding PF00501.28 ACT03804.1 - 0.00061 18.5 0.0 0.00094 17.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme ATPgrasp_YheCD PF14398.6 ACT03805.1 - 8.7e-60 202.1 0.2 1.1e-59 201.8 0.2 1.0 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACT03805.1 - 6.1e-08 32.3 0.1 0.002 17.4 0.0 2.3 2 1 0 2 2 2 2 Sugar-transfer associated ATP-grasp TTL PF03133.15 ACT03805.1 - 2.3e-06 27.0 0.0 1.4e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ABC_tran PF00005.27 ACT03806.1 - 1.5e-31 109.7 0.0 2e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT03806.1 - 7.2e-08 32.1 0.1 0.00095 18.7 0.0 2.1 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT03806.1 - 2e-06 27.8 0.3 0.034 14.0 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT03806.1 - 0.00016 21.3 0.0 0.0003 20.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT03806.1 - 0.0014 18.5 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 ACT03806.1 - 0.0015 18.3 0.2 0.036 13.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ACT03806.1 - 0.0042 17.5 0.1 0.0078 16.6 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 ACT03806.1 - 0.027 13.5 0.1 0.061 12.4 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_24 PF13479.6 ACT03806.1 - 0.033 13.9 0.1 0.21 11.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 ACT03806.1 - 0.034 13.9 0.2 0.082 12.6 0.1 1.6 1 1 1 2 2 2 0 Cytidylate kinase AAA_23 PF13476.6 ACT03806.1 - 0.037 14.5 0.0 0.056 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 ACT03806.1 - 0.04 13.8 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 ACT03806.1 - 0.048 13.6 0.0 0.14 12.1 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 ACT03806.1 - 0.056 13.3 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 ACT03806.1 - 0.057 13.7 0.1 0.11 12.8 0.1 1.9 1 1 0 1 1 1 0 AAA domain RNA12 PF10443.9 ACT03806.1 - 0.066 11.9 0.0 0.087 11.5 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein APS_kinase PF01583.20 ACT03806.1 - 0.091 12.7 0.1 0.18 11.7 0.0 1.5 2 0 0 2 2 1 0 Adenylylsulphate kinase NB-ARC PF00931.22 ACT03806.1 - 0.1 11.7 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_11 PF13086.6 ACT03806.1 - 0.11 12.2 0.0 0.6 9.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ACT03806.1 - 0.17 12.0 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase PMSR PF01625.21 ACT03807.1 - 2.2e-61 206.5 0.2 2.5e-61 206.3 0.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase DUF4860 PF16152.5 ACT03807.1 - 0.11 12.4 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4860) ADH_zinc_N PF00107.26 ACT03808.1 - 1.7e-11 44.2 0.0 2.9e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ACT03808.1 - 0.00016 21.5 0.1 0.0037 17.1 0.0 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ACT03808.1 - 0.0029 17.5 0.0 0.014 15.3 0.0 2.0 1 1 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ACT03808.1 - 0.0048 17.9 0.0 0.0087 17.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 ACT03808.1 - 0.015 14.8 0.1 0.025 14.1 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Epimerase PF01370.21 ACT03808.1 - 0.018 14.5 0.3 0.042 13.3 0.1 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ACT03808.1 - 0.055 13.3 0.1 0.09 12.7 0.1 1.3 1 0 0 1 1 1 0 NAD(P)H-binding NmrA PF05368.13 ACT03808.1 - 0.085 12.4 0.2 0.14 11.7 0.2 1.3 1 0 0 1 1 1 0 NmrA-like family DapB_N PF01113.20 ACT03808.1 - 0.17 12.0 0.2 1.5 9.0 0.1 2.2 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Methyltransf_3 PF01596.17 ACT03809.1 - 9e-39 132.8 0.0 1.1e-38 132.6 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ACT03809.1 - 1.1e-16 61.8 0.0 2.8e-16 60.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 ACT03809.1 - 7.8e-07 29.1 0.0 1e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 ACT03809.1 - 4.6e-05 23.3 0.0 8.6e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT03809.1 - 0.011 16.4 0.0 0.021 15.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 ACT03809.1 - 0.012 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 ACT03809.1 - 0.053 13.1 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase LysR_substrate PF03466.20 ACT03810.1 - 1.6e-37 128.9 0.0 2e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT03810.1 - 2.5e-18 65.7 0.3 5.4e-18 64.7 0.3 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 ACT03810.1 - 0.0013 17.9 0.0 0.017 14.2 0.0 2.1 1 1 0 1 1 1 1 PBP superfamily domain PBP_like_2 PF12849.7 ACT03810.1 - 0.056 13.1 0.0 0.17 11.5 0.0 1.8 2 0 0 2 2 2 0 PBP superfamily domain MycE_N PF17843.1 ACT03810.1 - 0.072 13.6 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 MycE methyltransferase N-terminal MarR_2 PF12802.7 ACT03810.1 - 0.15 12.0 0.6 0.25 11.2 0.1 1.6 2 0 0 2 2 2 0 MarR family DUF824 PF05688.11 ACT03810.1 - 0.16 11.8 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF824) Alpha-amylase PF00128.24 ACT03811.1 - 2.2e-44 152.4 1.0 2.7e-27 96.2 0.1 3.3 2 1 0 2 2 2 2 Alpha amylase, catalytic domain SLH PF00395.20 ACT03811.1 - 1.6e-31 108.1 2.9 2.6e-10 40.1 0.3 4.0 3 0 0 3 3 3 3 S-layer homology domain AMPK1_CBM PF16561.5 ACT03811.1 - 5.8e-11 42.5 2.5 0.0011 19.2 0.0 5.3 5 0 0 5 5 5 3 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 ACT03811.1 - 1.1e-06 28.8 0.0 0.18 12.2 0.0 4.9 4 0 0 4 4 4 2 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) fn3 PF00041.21 ACT03811.1 - 0.00012 22.3 3.0 0.15 12.4 0.2 3.5 3 0 0 3 3 3 2 Fibronectin type III domain hDGE_amylase PF14701.6 ACT03811.1 - 0.00058 19.1 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain Malt_amylase_C PF16657.5 ACT03811.1 - 0.0038 17.3 0.0 0.015 15.4 0.0 2.0 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain Alpha-amylase_N PF02903.14 ACT03811.1 - 0.025 14.7 0.1 0.26 11.5 0.0 2.8 4 0 0 4 4 4 0 Alpha amylase, N-terminal ig-like domain Tissue_fac PF01108.17 ACT03811.1 - 0.026 14.4 0.2 6.3 6.7 0.0 2.5 2 0 0 2 2 2 0 Tissue factor DUF3606 PF12244.8 ACT03811.1 - 0.059 13.3 0.2 0.25 11.3 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) Invasin_D3 PF09134.10 ACT03811.1 - 0.17 12.2 0.0 0.17 12.2 0.0 5.1 5 1 1 6 6 6 0 Invasin, domain 3 Acetyltransf_8 PF13523.6 ACT03812.1 - 1.9e-27 95.7 0.1 2.4e-27 95.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACT03812.1 - 3.4e-15 56.9 0.1 4.6e-15 56.5 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ACT03812.1 - 4.4e-14 52.7 0.2 5.9e-14 52.3 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT03812.1 - 3.4e-05 24.2 0.5 0.00011 22.5 0.4 2.0 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT03812.1 - 0.0032 17.4 0.0 0.0051 16.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ACT03812.1 - 0.0034 17.3 0.0 0.0053 16.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain HTH_18 PF12833.7 ACT03813.1 - 1.7e-19 69.9 1.0 3.5e-19 68.9 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03813.1 - 3.6e-18 65.2 1.8 1.2e-07 31.7 0.0 3.6 4 0 0 4 4 4 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03813.1 - 1.2e-11 44.7 0.1 3.4e-11 43.2 0.1 1.7 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT03813.1 - 3.6e-08 33.0 0.1 1.2e-07 31.3 0.1 1.8 2 0 0 2 2 2 1 Cupin domain GFO_IDH_MocA PF01408.22 ACT03814.1 - 1.1e-07 32.7 0.0 2.2e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03814.1 - 1.3e-06 28.4 0.1 2.3e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.22 ACT03815.1 - 1e-28 100.6 0.0 1.6e-28 99.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03815.1 - 2.8e-08 33.8 0.3 5.9e-08 32.7 0.3 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACT03815.1 - 4.6e-05 24.1 0.0 0.0001 22.9 0.0 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.15 ACT03815.1 - 0.076 11.9 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Alpha-L-AF_C PF06964.12 ACT03817.1 - 8e-41 140.0 0.0 1.3e-40 139.3 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain RTP801_C PF07809.11 ACT03818.1 - 0.068 13.1 0.7 0.22 11.5 0.1 1.8 1 1 0 2 2 2 0 RTP801 C-terminal region HTH_18 PF12833.7 ACT03819.1 - 1.3e-19 70.2 0.1 2.5e-19 69.3 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03819.1 - 2e-17 62.8 0.6 2.8e-09 36.9 0.1 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family MarR_2 PF12802.7 ACT03819.1 - 0.0036 17.1 0.0 0.24 11.3 0.0 2.8 2 1 0 2 2 2 1 MarR family AraC_binding PF02311.19 ACT03819.1 - 0.0039 17.1 0.1 0.021 14.7 0.1 2.0 2 1 0 2 2 2 1 AraC-like ligand binding domain HTH_18 PF12833.7 ACT03820.1 - 1.8e-19 69.7 0.6 1.8e-19 69.7 0.6 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03820.1 - 2.5e-14 52.9 0.2 4e-07 30.0 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03820.1 - 1.1e-09 38.3 0.0 2.7e-09 37.0 0.0 1.7 1 1 0 1 1 1 1 AraC-like ligand binding domain HTH_5 PF01022.20 ACT03820.1 - 0.0019 18.0 0.2 0.0058 16.5 0.1 1.8 1 1 1 2 2 2 1 Bacterial regulatory protein, arsR family DprA_WH PF17782.1 ACT03820.1 - 0.0051 16.9 0.1 0.015 15.4 0.1 1.8 1 0 0 1 1 1 1 DprA winged helix domain HTH_IclR PF09339.10 ACT03820.1 - 0.0071 16.1 1.3 0.011 15.5 0.2 1.9 2 1 0 2 2 2 1 IclR helix-turn-helix domain Cupin_2 PF07883.11 ACT03820.1 - 0.0085 15.8 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Cupin domain HTH_37 PF13744.6 ACT03820.1 - 0.011 15.7 0.2 0.018 15.0 0.2 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.6 ACT03820.1 - 0.017 14.7 0.1 0.043 13.4 0.1 1.7 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_3 PF01381.22 ACT03820.1 - 0.018 15.1 0.0 0.099 12.7 0.0 2.0 1 1 1 2 2 2 0 Helix-turn-helix Rrf2 PF02082.20 ACT03820.1 - 0.061 13.7 0.1 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator HTH_20 PF12840.7 ACT03820.1 - 0.079 13.0 1.0 2.1 8.5 0.1 3.2 3 1 1 4 4 4 0 Helix-turn-helix domain HTH_31 PF13560.6 ACT03820.1 - 0.081 13.3 0.1 0.32 11.4 0.1 1.9 1 1 1 2 2 2 0 Helix-turn-helix domain DUF2059 PF09832.9 ACT03820.1 - 0.093 12.8 0.0 23 5.1 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2059) CREPT PF16566.5 ACT03820.1 - 0.12 12.5 0.1 0.23 11.6 0.1 1.4 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour MarR_2 PF12802.7 ACT03820.1 - 0.13 12.2 0.2 2.2 8.2 0.0 2.2 1 1 1 2 2 2 0 MarR family HTH_26 PF13443.6 ACT03820.1 - 0.14 12.6 0.1 0.64 10.5 0.1 2.1 1 1 1 2 2 2 0 Cro/C1-type HTH DNA-binding domain PhyH PF05721.13 ACT03821.1 - 1.6e-34 120.0 0.0 2.2e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) tRNA-synt_1c_C PF03950.18 ACT03821.1 - 0.045 13.6 0.2 0.22 11.4 0.1 2.2 3 0 0 3 3 3 0 tRNA synthetases class I (E and Q), anti-codon binding domain DUF1479 PF07350.12 ACT03821.1 - 0.1 11.3 0.0 0.62 8.8 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1479) PfkB PF00294.24 ACT03822.1 - 1.9e-74 250.7 0.0 2.2e-74 250.5 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Peripla_BP_3 PF13377.6 ACT03823.1 - 3.2e-30 105.6 0.0 1.8e-29 103.2 0.0 1.9 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT03823.1 - 3.2e-24 85.8 0.0 3.9e-24 85.5 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT03823.1 - 2.3e-21 75.3 0.1 4.3e-21 74.4 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACT03823.1 - 7.4e-17 61.8 0.0 1.6e-16 60.7 0.0 1.5 1 1 0 1 1 1 1 Periplasmic binding protein domain HTH_3 PF01381.22 ACT03823.1 - 0.00046 20.2 0.1 0.00084 19.4 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_Tnp_ISL3 PF13542.6 ACT03823.1 - 0.013 14.9 0.0 0.031 13.7 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_IclR PF09339.10 ACT03823.1 - 0.023 14.5 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_31 PF13560.6 ACT03823.1 - 0.034 14.5 0.0 0.064 13.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain TrmB PF01978.19 ACT03823.1 - 0.053 13.4 0.1 0.15 11.9 0.1 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_7 PF02796.15 ACT03823.1 - 0.059 13.4 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_10 PF04967.12 ACT03823.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain Sigma54_DBD PF04552.13 ACT03823.1 - 0.14 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-54, DNA binding domain HTH_23 PF13384.6 ACT03823.1 - 0.19 11.6 0.0 0.44 10.4 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain BPD_transp_1 PF00528.22 ACT03824.1 - 1.9e-15 57.1 14.6 1.9e-15 57.1 14.6 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component PUA_2 PF14306.6 ACT03824.1 - 0.18 11.5 0.0 0.37 10.4 0.0 1.5 1 1 0 1 1 1 0 PUA-like domain BPD_transp_1 PF00528.22 ACT03825.1 - 1.7e-15 57.3 11.9 1.7e-15 57.3 11.9 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component Cpta_toxin PF07254.12 ACT03825.1 - 0.14 12.1 2.7 0.16 12.0 1.2 1.9 2 0 0 2 2 2 0 Membrane-bound toxin component of toxin-antitoxin system SBP_bac_1 PF01547.25 ACT03826.1 - 1.6e-11 44.7 8.3 5.3e-11 43.0 8.3 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT03826.1 - 2.9e-08 33.9 5.8 6.6e-08 32.7 5.8 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Glyco_hydro_32N PF00251.20 ACT03827.1 - 1.2e-98 330.5 3.4 1.5e-98 330.2 3.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 ACT03827.1 - 7.3e-22 78.1 0.0 1.2e-21 77.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal BNR_2 PF13088.6 ACT03827.1 - 0.024 13.9 0.6 3.9 6.7 0.0 2.2 1 1 0 2 2 2 0 BNR repeat-like domain Sortilin-Vps10 PF15902.5 ACT03827.1 - 0.14 10.9 0.4 0.61 8.8 0.1 1.5 1 1 0 1 1 1 0 Sortilin, neurotensin receptor 3, BNR PF02012.20 ACT03827.1 - 0.18 11.9 0.3 0.18 11.9 0.3 2.6 2 0 0 2 2 2 0 BNR/Asp-box repeat Bac_luciferase PF00296.20 ACT03828.1 - 5.1e-71 239.7 0.0 6.1e-71 239.4 0.0 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase MtrA PF04208.14 ACT03828.1 - 0.22 11.1 0.0 0.4 10.3 0.0 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit A MFS_1 PF07690.16 ACT03829.1 - 2.3e-40 138.6 54.6 2.3e-40 138.6 54.6 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily PufQ PF05398.11 ACT03829.1 - 1.3 9.2 7.7 0.39 10.9 0.6 3.3 3 0 0 3 3 3 0 PufQ cytochrome subunit ABC_tran PF00005.27 ACT03830.1 - 1.6e-57 193.9 0.0 6.8e-29 101.1 0.0 2.2 2 0 0 2 2 2 2 ABC transporter oligo_HPY PF08352.12 ACT03830.1 - 9e-43 144.6 3.2 1.6e-20 73.4 0.3 2.4 2 0 0 2 2 2 2 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 ACT03830.1 - 2e-11 44.3 0.4 0.00017 21.6 0.1 4.1 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT03830.1 - 3.7e-08 33.1 1.1 0.0049 16.3 0.0 3.3 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT03830.1 - 2.3e-06 27.2 0.7 0.015 15.0 0.2 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT03830.1 - 4e-06 27.3 0.6 0.041 14.3 0.1 2.7 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ACT03830.1 - 2.7e-05 24.2 0.3 0.026 14.4 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Sigma54_activat PF00158.26 ACT03830.1 - 3.2e-05 23.7 2.6 0.24 11.1 0.0 3.9 4 0 0 4 4 4 1 Sigma-54 interaction domain AAA_22 PF13401.6 ACT03830.1 - 4.8e-05 23.7 6.0 0.38 11.0 0.7 3.8 3 1 0 3 3 3 2 AAA domain AAA_7 PF12775.7 ACT03830.1 - 0.00023 20.7 0.3 0.061 12.8 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 ACT03830.1 - 0.00053 20.0 0.9 0.43 10.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ATP-synt_ab PF00006.25 ACT03830.1 - 0.00061 19.5 0.1 0.11 12.1 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 ACT03830.1 - 0.00079 19.9 0.7 0.65 10.4 0.0 3.4 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ACT03830.1 - 0.00088 19.2 0.5 0.3 11.0 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 ACT03830.1 - 0.00096 19.3 0.1 0.46 10.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ACT03830.1 - 0.0011 18.7 0.8 1.3 8.7 0.0 2.8 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_18 PF13238.6 ACT03830.1 - 0.0015 19.1 0.4 2.5 8.7 0.1 2.6 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 ACT03830.1 - 0.0015 18.5 0.3 0.25 11.3 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 ACT03830.1 - 0.0027 17.5 0.4 2 8.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ACT03830.1 - 0.0049 16.6 1.5 0.55 9.9 0.2 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ACT03830.1 - 0.014 15.8 0.7 2.8 8.4 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_23 PF13476.6 ACT03830.1 - 0.018 15.6 0.5 2.7 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 ACT03830.1 - 0.02 15.0 2.1 0.85 9.7 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain Roc PF08477.13 ACT03830.1 - 0.027 14.7 0.1 7.2 6.8 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ACT03830.1 - 0.027 14.5 0.2 0.39 10.8 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase T2SSE PF00437.20 ACT03830.1 - 0.028 13.5 0.1 2.4 7.1 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein NB-ARC PF00931.22 ACT03830.1 - 0.037 13.2 0.7 7.3 5.7 0.1 2.7 3 0 0 3 3 3 0 NB-ARC domain Myosin_head PF00063.21 ACT03830.1 - 0.041 12.1 0.0 0.074 11.3 0.0 1.3 1 0 0 1 1 1 0 Myosin head (motor domain) ATPase PF06745.13 ACT03830.1 - 0.045 13.1 1.7 6.1 6.1 0.1 2.7 3 0 0 3 3 3 0 KaiC ResIII PF04851.15 ACT03830.1 - 0.067 13.2 0.4 0.33 10.9 0.0 2.2 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 ACT03830.1 - 0.071 12.4 0.2 8.9 5.5 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin TniB PF05621.11 ACT03830.1 - 0.08 12.3 3.5 2.1 7.7 0.1 3.6 4 0 0 4 4 4 0 Bacterial TniB protein DEAD PF00270.29 ACT03830.1 - 0.085 12.6 0.0 1.5 8.6 0.0 2.4 2 2 0 2 2 2 0 DEAD/DEAH box helicase AAA_25 PF13481.6 ACT03830.1 - 0.11 12.0 1.9 61 3.1 0.1 3.8 4 0 0 4 4 4 0 AAA domain Mg_chelatase PF01078.21 ACT03830.1 - 0.14 11.6 0.0 8 5.8 0.0 2.7 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI TrwB_AAD_bind PF10412.9 ACT03830.1 - 0.15 10.9 0.1 14 4.4 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Pox_A32 PF04665.12 ACT03830.1 - 0.29 10.6 0.3 9.2 5.6 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_15 PF13175.6 ACT03830.1 - 0.31 10.7 1.5 8.1 6.0 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain DUF815 PF05673.13 ACT03830.1 - 0.5 9.5 2.1 8.8 5.4 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF815) PduV-EutP PF10662.9 ACT03830.1 - 0.86 9.3 2.3 17 5.2 0.1 2.7 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation BPD_transp_1 PF00528.22 ACT03831.1 - 2.9e-29 102.1 10.1 2.9e-29 102.1 10.1 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 ACT03831.1 - 0.0031 17.5 1.1 0.0031 17.5 1.1 2.3 2 1 0 2 2 2 1 N-terminal TM domain of oligopeptide transport permease C BPD_transp_1 PF00528.22 ACT03832.1 - 1.6e-39 135.6 13.7 1.6e-39 135.6 13.7 1.7 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_5 PF00496.22 ACT03833.1 - 9.4e-92 307.9 7.4 1.3e-91 307.4 7.4 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle DUF3879 PF12995.7 ACT03833.1 - 0.041 13.6 0.3 16 5.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function, E. rectale Gene description (DUF3879) HPP PF04982.13 ACT03833.1 - 0.16 12.2 0.0 0.34 11.1 0.0 1.6 1 0 0 1 1 1 0 HPP family Bac_luciferase PF00296.20 ACT03834.1 - 1.5e-62 211.8 0.1 2.3e-62 211.2 0.1 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase Peptidase_M20 PF01546.28 ACT03835.1 - 1.2e-29 103.6 0.7 1.7e-29 103.0 0.7 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ACT03835.1 - 6.9e-06 26.0 0.8 1.6e-05 24.7 0.8 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Bac_luciferase PF00296.20 ACT03836.1 - 3e-62 210.9 0.1 4.2e-62 210.4 0.1 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase DinB_2 PF12867.7 ACT03837.1 - 7.8e-12 45.8 0.2 9.7e-12 45.5 0.2 1.1 1 0 0 1 1 1 1 DinB superfamily DUF1572 PF07609.11 ACT03837.1 - 9e-06 25.6 1.0 1.1e-05 25.3 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1572) DUF664 PF04978.12 ACT03837.1 - 0.0001 22.8 0.7 0.0003 21.2 0.7 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF664) DinB PF05163.12 ACT03837.1 - 0.12 12.3 3.2 2.1 8.3 3.2 2.1 1 1 0 1 1 1 0 DinB family CotJB PF12652.7 ACT03837.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 CotJB protein Peptidase_M20 PF01546.28 ACT03838.1 - 9.9e-33 113.6 0.3 1.5e-32 113.0 0.3 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ACT03838.1 - 2.5e-09 37.0 0.2 6.9e-09 35.6 0.0 1.9 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ACT03838.1 - 0.043 13.5 0.1 3.9 7.1 0.0 2.9 3 0 0 3 3 3 0 Peptidase family M28 Bac_luciferase PF00296.20 ACT03839.1 - 5.3e-35 121.4 2.7 7.5e-35 120.9 2.7 1.2 1 1 0 1 1 1 1 Luciferase-like monooxygenase ABC_tran PF00005.27 ACT03840.1 - 9.8e-35 120.1 0.1 1.3e-34 119.7 0.1 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT03840.1 - 4.7e-15 56.2 0.1 1.3e-06 28.5 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT03840.1 - 3.2e-08 33.3 0.0 1e-06 28.4 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ACT03840.1 - 2.5e-06 28.1 0.1 4.3e-06 27.4 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_13 PF13166.6 ACT03840.1 - 7e-05 21.7 0.0 0.061 12.0 0.0 2.1 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ACT03840.1 - 0.00018 22.0 0.1 0.00021 21.7 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ACT03840.1 - 0.00032 20.4 0.0 0.00059 19.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.9 ACT03840.1 - 0.0004 19.3 0.8 0.89 8.3 0.1 3.0 2 1 0 2 2 2 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 ACT03840.1 - 0.0053 17.0 0.1 0.0094 16.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ACT03840.1 - 0.0069 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ACT03840.1 - 0.0069 16.9 0.0 0.012 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT03840.1 - 0.0077 16.2 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase ATPase_2 PF01637.18 ACT03840.1 - 0.012 15.6 0.1 0.02 14.8 0.1 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 ACT03840.1 - 0.015 15.3 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 ACT03840.1 - 0.038 13.6 0.1 0.15 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ACT03840.1 - 0.047 13.8 0.0 0.098 12.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ACT03840.1 - 0.054 12.8 0.2 2.5 7.4 0.0 2.7 3 0 0 3 3 3 0 KaiC cobW PF02492.19 ACT03840.1 - 0.054 13.1 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 ACT03840.1 - 0.058 13.8 0.0 3.7 8.0 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ACT03840.1 - 0.06 13.1 0.0 0.089 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ACT03840.1 - 0.062 12.5 0.0 0.098 11.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_19 PF13245.6 ACT03840.1 - 0.064 13.6 0.1 0.073 13.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 ACT03840.1 - 0.097 11.7 0.1 0.2 10.7 0.1 1.5 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.6 ACT03840.1 - 0.11 12.8 0.0 0.36 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ACT03840.1 - 0.15 11.8 0.0 1.4 8.5 0.0 1.9 1 1 0 2 2 2 0 AAA ATPase domain G-alpha PF00503.20 ACT03840.1 - 0.16 11.1 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit BPD_transp_1 PF00528.22 ACT03841.1 - 8.3e-16 58.3 11.9 8.3e-16 58.3 11.9 1.8 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component MtrF PF09472.10 ACT03841.1 - 0.76 9.2 3.9 0.89 9.0 0.6 2.7 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) DUF3169 PF11368.8 ACT03841.1 - 0.88 9.0 4.7 0.55 9.7 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) BPD_transp_1 PF00528.22 ACT03842.1 - 1.3e-20 73.9 16.3 1.8e-20 73.4 16.3 1.2 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_3 PF00497.20 ACT03843.1 - 1.3e-45 155.6 0.3 1.6e-45 155.3 0.3 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Phosphonate-bd PF12974.7 ACT03843.1 - 1.2e-05 25.1 0.4 2.4e-05 24.0 0.4 1.6 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1 PF09084.11 ACT03843.1 - 3.8e-05 23.7 0.1 9.2e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_3 PF16868.5 ACT03843.1 - 0.0017 17.8 0.0 0.003 17.0 0.0 1.3 1 0 0 1 1 1 1 NMT1-like family SBP_bac_11 PF13531.6 ACT03843.1 - 0.011 15.5 0.2 0.48 10.1 0.0 2.2 1 1 1 2 2 2 0 Bacterial extracellular solute-binding protein LysR_substrate PF03466.20 ACT03843.1 - 0.043 13.2 0.0 0.075 12.4 0.0 1.4 1 0 0 1 1 1 0 LysR substrate binding domain Acetyltransf_1 PF00583.25 ACT03844.1 - 3.1e-10 40.3 0.0 4.2e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT03844.1 - 5e-10 39.7 0.0 7.3e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT03844.1 - 3.9e-08 33.3 0.0 5.3e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT03844.1 - 0.04 14.0 0.0 0.083 13.0 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain LysR_substrate PF03466.20 ACT03845.1 - 7.8e-38 129.9 0.0 1e-37 129.6 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT03845.1 - 2.5e-17 62.6 0.0 4.4e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 ACT03845.1 - 0.00059 19.6 0.0 0.0018 18.0 0.0 1.7 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain DUF2089 PF09862.9 ACT03845.1 - 0.0088 16.1 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2089) HTH_24 PF13412.6 ACT03845.1 - 0.12 12.0 0.2 0.67 9.6 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Alpha_L_fucos PF01120.17 ACT03846.1 - 3.7e-39 135.2 0.0 1.2e-37 130.2 0.0 2.2 1 1 1 2 2 2 2 Alpha-L-fucosidase GHL6 PF14871.6 ACT03846.1 - 0.00094 19.3 0.0 0.0018 18.4 0.0 1.6 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase 6 Glyco_hydro_35 PF01301.19 ACT03847.1 - 1.4e-112 376.4 0.0 1.8e-112 376.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 ACT03847.1 - 1.7e-10 40.8 0.3 3.2e-09 36.6 0.0 2.6 2 1 0 2 2 2 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 ACT03847.1 - 1.9e-05 25.2 0.1 0.058 14.0 0.0 2.8 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain SBP_bac_1 PF01547.25 ACT03848.1 - 2.2e-22 80.5 10.2 3.4e-22 79.8 10.2 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT03849.1 - 6.6e-17 61.8 26.8 7.5e-15 55.1 26.8 2.1 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT03850.1 - 6.1e-16 58.7 16.8 6.1e-16 58.7 16.8 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Caveolin PF01146.17 ACT03850.1 - 0.13 12.3 4.4 0.37 10.7 4.4 1.7 1 0 0 1 1 1 0 Caveolin Response_reg PF00072.24 ACT03851.1 - 2.9e-21 75.7 0.6 6.2e-21 74.7 0.6 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT03851.1 - 1.1e-17 64.0 0.1 2.6e-17 62.8 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03851.1 - 1e-16 60.5 2.0 5.3e-08 32.8 0.1 2.8 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family His_kinase PF06580.13 ACT03852.1 - 3e-17 62.7 0.2 1.2e-16 60.8 0.2 2.1 1 0 0 1 1 1 1 Histidine kinase HAMP PF00672.25 ACT03852.1 - 1e-12 48.2 0.3 3.1e-12 46.7 0.2 1.9 2 0 0 2 2 2 1 HAMP domain dCache_1 PF02743.18 ACT03852.1 - 1.4e-07 31.6 2.5 2.3e-07 30.8 2.5 1.4 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT03852.1 - 2.4e-05 24.8 0.0 4.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PDR_assoc PF08370.11 ACT03852.1 - 0.059 13.1 0.1 0.16 11.7 0.1 1.7 1 0 0 1 1 1 0 Plant PDR ABC transporter associated HATPase_c_3 PF13589.6 ACT03852.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NapE PF06796.11 ACT03852.1 - 0.44 10.1 7.4 0.18 11.4 0.9 2.9 3 0 0 3 3 3 0 Periplasmic nitrate reductase protein NapE Glyco_hydro_88 PF07470.13 ACT03853.1 - 1.8e-42 145.7 0.1 2.2e-42 145.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 DNA_ligase_IV PF11411.8 ACT03853.1 - 0.049 13.8 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 DNA ligase IV Glyco_hydro_43 PF04616.14 ACT03854.1 - 3.1e-23 82.5 6.9 6.2e-23 81.5 6.9 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 F5_F8_type_C PF00754.25 ACT03854.1 - 4.7e-18 65.5 10.9 4.7e-18 65.5 10.9 2.7 3 0 0 3 3 3 1 F5/8 type C domain DUF4992 PF16383.5 ACT03854.1 - 0.011 15.3 0.8 0.022 14.3 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function DoxX PF07681.12 ACT03856.1 - 3.3e-08 34.0 4.4 3.3e-08 34.0 4.4 1.7 2 0 0 2 2 2 1 DoxX DoxD PF04173.13 ACT03856.1 - 1.1e-05 25.4 3.1 2.6e-05 24.2 3.1 1.6 1 1 0 1 1 1 1 TQO small subunit DoxD NDK PF00334.19 ACT03857.1 - 3.8e-49 166.2 0.0 4.3e-49 166.0 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DUF5499 PF17603.2 ACT03857.1 - 0.12 13.0 0.0 0.19 12.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5499) PAS_3 PF08447.12 ACT03858.1 - 5.5e-13 49.0 0.1 1.3e-12 47.9 0.1 1.6 1 0 0 1 1 1 1 PAS fold HisKA_3 PF07730.13 ACT03858.1 - 7.4e-13 48.8 0.0 3.7e-12 46.6 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase PAS_9 PF13426.7 ACT03858.1 - 2.4e-12 47.0 0.0 5.3e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 ACT03858.1 - 1.8e-11 44.0 0.0 8.7e-11 41.8 0.0 2.2 2 0 0 2 2 2 1 PAS fold HATPase_c PF02518.26 ACT03858.1 - 9.6e-07 29.3 1.0 1.2e-05 25.7 0.5 2.7 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_4 PF08448.10 ACT03858.1 - 4.7e-06 26.8 0.0 1.3e-05 25.4 0.0 1.7 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 ACT03858.1 - 7e-05 22.7 0.0 0.00016 21.6 0.0 1.6 1 0 0 1 1 1 1 PAS domain HATPase_c_2 PF13581.6 ACT03858.1 - 0.0035 17.3 0.1 0.0076 16.2 0.1 1.7 1 1 0 1 1 1 1 Histidine kinase-like ATPase domain DUF2634 PF10934.8 ACT03858.1 - 0.036 14.2 1.7 0.043 13.9 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2634) PAS_12 PF18095.1 ACT03858.1 - 0.058 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain Response_reg PF00072.24 ACT03859.1 - 1.1e-26 93.2 0.7 1.6e-26 92.7 0.3 1.5 2 0 0 2 2 2 1 Response regulator receiver domain GerE PF00196.19 ACT03859.1 - 1.6e-20 72.4 1.1 3.3e-20 71.4 1.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACT03859.1 - 2.5e-06 27.1 0.1 5.9e-06 25.9 0.1 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT03859.1 - 0.0016 17.9 0.0 0.0035 16.8 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACT03859.1 - 0.02 14.8 0.4 0.091 12.6 0.1 1.9 1 1 1 2 2 2 0 ECF sigma factor HTH_Crp_2 PF13545.6 ACT03861.1 - 5.3e-18 64.8 0.0 8.6e-18 64.1 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain cNMP_binding PF00027.29 ACT03861.1 - 3.6e-16 59.0 0.0 7.1e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Crp PF00325.20 ACT03861.1 - 9.5e-10 38.0 0.0 1.9e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, crp family HTH_24 PF13412.6 ACT03861.1 - 0.0015 18.0 0.0 0.0027 17.2 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_46 PF15977.5 ACT03861.1 - 0.025 14.6 0.0 0.049 13.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA binding Phage_rep_O PF04492.13 ACT03861.1 - 0.045 14.3 0.0 0.077 13.6 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage replication protein O Radical_SAM PF04055.21 ACT03862.1 - 1.2e-29 103.9 0.0 1.6e-29 103.5 0.0 1.1 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 ACT03862.1 - 3e-20 72.9 0.0 3.8e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 ACT03862.1 - 2.5e-09 37.3 0.0 3.5e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain PFL-like PF02901.15 ACT03863.1 - 7.4e-205 682.4 0.0 9.7e-205 682.0 0.0 1.1 1 0 0 1 1 1 1 Pyruvate formate lyase-like Gly_radical PF01228.21 ACT03863.1 - 4.7e-44 149.3 0.0 1e-43 148.2 0.0 1.6 1 0 0 1 1 1 1 Glycine radical DUF3029 PF11230.8 ACT03863.1 - 0.0054 15.2 0.0 0.023 13.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3029) DUF4715 PF15835.5 ACT03863.1 - 0.1 12.6 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4715) ATP-synt_D PF01813.17 ACT03863.1 - 0.14 11.9 0.3 0.29 10.9 0.3 1.4 1 0 0 1 1 1 0 ATP synthase subunit D NTP_transf_3 PF12804.7 ACT03864.1 - 1.2e-15 58.3 0.0 1.4e-15 58.0 0.0 1.0 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hemerythrin PF01814.23 ACT03865.1 - 2.6e-09 37.8 5.0 7.4e-06 26.6 0.6 2.2 1 1 0 2 2 2 2 Hemerythrin HHE cation binding domain DDE_Tnp_1_6 PF13751.6 ACT03866.1 - 6.8e-17 61.9 0.0 8e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1 PF01609.21 ACT03866.1 - 0.014 15.1 0.1 0.016 14.9 0.1 1.2 1 0 0 1 1 1 0 Transposase DDE domain Bac_rhamnosid6H PF17389.2 ACT03867.1 - 2.9e-13 49.8 4.6 8.7e-10 38.4 0.6 2.6 2 1 1 3 3 3 2 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 ACT03867.1 - 5.6e-13 48.5 0.1 1.2e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain HTH_18 PF12833.7 ACT03868.1 - 4.5e-22 78.1 0.0 1.3e-21 76.6 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03868.1 - 6.2e-11 42.1 0.1 1.2e-06 28.5 0.0 2.9 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT03868.1 - 1.4e-08 35.0 1.6 1.8e-07 31.4 0.0 2.7 2 1 1 3 3 3 1 GGDEF-like domain AChE_tetra PF08674.10 ACT03868.1 - 0.15 11.8 1.5 0.4 10.4 1.5 1.7 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain SBP_bac_1 PF01547.25 ACT03869.1 - 1.6e-20 74.3 12.8 3.1e-20 73.3 12.8 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT03869.1 - 1.4e-17 64.5 6.8 1.4e-17 64.5 6.8 1.6 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein TraH_2 PF06871.11 ACT03869.1 - 0.038 13.6 0.1 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 TraH_2 BPD_transp_1 PF00528.22 ACT03870.1 - 6.7e-15 55.3 19.0 6.7e-15 55.3 19.0 2.0 1 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF1072 PF06380.11 ACT03870.1 - 0.019 14.8 0.7 0.019 14.8 0.7 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1072) BPD_transp_1 PF00528.22 ACT03871.1 - 1.2e-12 48.0 17.8 1.2e-12 48.0 17.8 2.1 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Peptidase_S9 PF00326.21 ACT03872.1 - 1.4e-11 44.3 0.0 1.2e-10 41.2 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 ACT03872.1 - 5.4e-11 42.8 0.0 2.1e-09 37.6 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 ACT03872.1 - 3.5e-06 26.7 0.0 0.0049 16.4 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 ACT03872.1 - 0.00058 19.7 0.0 1 9.2 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 ACT03872.1 - 0.0037 16.6 0.0 2.1 7.6 0.0 2.5 3 0 0 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ACT03872.1 - 0.095 12.3 0.0 0.86 9.2 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold BAAT_C PF08840.11 ACT03872.1 - 0.16 11.9 0.0 0.46 10.4 0.0 1.7 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal TetR_N PF00440.23 ACT03873.1 - 4.9e-08 32.6 0.1 1e-07 31.6 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family DUF1659 PF07872.11 ACT03873.1 - 0.073 12.7 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1659) HTH_AraC PF00165.23 ACT03873.1 - 0.095 12.8 0.0 0.26 11.5 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family MMPL PF03176.15 ACT03874.1 - 4.3e-81 272.4 40.2 1.9e-51 175.0 23.8 2.5 2 1 0 2 2 2 2 MMPL family Sterol-sensing PF12349.8 ACT03874.1 - 0.00027 20.8 3.9 0.00027 20.8 3.9 3.1 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ACT03874.1 - 1.2 7.1 6.4 0.18 9.8 2.0 1.7 2 0 0 2 2 2 0 Patched family Lipase_GDSL_2 PF13472.6 ACT03875.1 - 1.7e-27 97.0 0.1 1.9e-27 96.8 0.1 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ACT03875.1 - 9.8e-14 51.8 0.0 1.2e-13 51.5 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF1593 PF07632.11 ACT03875.1 - 0.088 12.2 0.0 0.59 9.5 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1593) Radical_SAM PF04055.21 ACT03876.1 - 3.1e-08 34.2 0.0 4.3e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily DUF5131 PF07505.11 ACT03876.1 - 9.6e-05 22.0 0.0 0.00013 21.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF5131) HATPase_c PF02518.26 ACT03877.1 - 3.9e-20 72.4 0.2 9.3e-20 71.2 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT03877.1 - 7.2e-15 54.8 3.3 1.9e-14 53.4 0.2 3.2 3 1 0 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 ACT03877.1 - 2.9e-08 33.9 0.0 3.1e-05 24.2 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 ACT03877.1 - 9.2e-08 32.3 0.5 1.9e-05 24.8 0.1 2.8 2 1 0 2 2 2 1 PAS domain PAS PF00989.25 ACT03877.1 - 0.00057 19.9 0.3 0.0032 17.5 0.1 2.4 3 0 0 3 3 3 1 PAS fold MEKHLA PF08670.11 ACT03877.1 - 0.0012 18.8 0.0 0.0023 17.9 0.0 1.4 1 0 0 1 1 1 1 MEKHLA domain sCache_3_3 PF17202.4 ACT03877.1 - 0.044 14.2 0.1 0.11 12.9 0.1 1.6 1 0 0 1 1 1 0 Single cache domain 3 HATPase_c_2 PF13581.6 ACT03877.1 - 0.045 13.7 0.0 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain PAS_3 PF08447.12 ACT03877.1 - 0.12 12.6 0.0 0.67 10.3 0.0 2.2 2 0 0 2 2 2 0 PAS fold AP_endonuc_2 PF01261.24 ACT03878.1 - 2.8e-21 75.9 0.3 3.8e-21 75.5 0.3 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel GNAT_C PF18164.1 ACT03879.1 - 1.9e-39 134.8 0.0 2.7e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 GNAT-like C-terminal domain DUF5596 PF18082.1 ACT03879.1 - 2.6e-16 59.2 1.1 5.6e-16 58.1 1.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5596) Response_reg PF00072.24 ACT03880.1 - 1.1e-24 86.7 0.0 2.4e-24 85.7 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT03880.1 - 1.1e-19 70.5 0.0 2.9e-19 69.1 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03880.1 - 1.9e-13 50.1 0.1 1.4e-08 34.6 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF5088 PF17008.5 ACT03880.1 - 0.019 14.7 0.3 0.041 13.6 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5088) His_kinase PF06580.13 ACT03881.1 - 5.3e-21 74.7 2.7 5.3e-21 74.7 2.7 2.8 4 0 0 4 4 4 1 Histidine kinase HATPase_c PF02518.26 ACT03881.1 - 0.016 15.7 0.0 0.032 14.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACT03881.1 - 0.033 14.0 0.5 0.1 12.4 0.5 1.9 1 1 0 1 1 1 0 Cache domain DUF3502 PF12010.8 ACT03882.1 - 2.1e-25 89.9 1.8 5e-25 88.6 1.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) SBP_bac_8 PF13416.6 ACT03882.1 - 6e-14 52.5 0.4 1.2e-13 51.5 0.4 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT03882.1 - 1.4e-13 51.5 3.2 2.3e-13 50.8 0.9 2.4 2 1 0 2 2 2 1 Bacterial extracellular solute-binding protein Neisseria_PilC PF05567.11 ACT03882.1 - 0.14 11.1 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Neisseria PilC beta-propeller domain SLH PF00395.20 ACT03883.1 - 5.2e-38 128.8 5.3 1.1e-14 54.2 0.6 3.8 3 0 0 3 3 3 3 S-layer homology domain DUF4832 PF16116.5 ACT03883.1 - 3.1e-21 76.2 0.0 3.3e-09 36.9 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4832) CBM_11 PF03425.13 ACT03883.1 - 3.2e-13 50.0 9.7 3.7e-06 26.9 0.9 4.7 4 1 0 4 4 4 2 Carbohydrate binding domain (family 11) Big_2 PF02368.18 ACT03883.1 - 2e-10 40.4 5.5 5.9e-10 38.9 5.5 1.8 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 2) DUF4874 PF16173.5 ACT03883.1 - 5e-10 39.3 0.0 0.00039 20.1 0.0 3.0 2 1 0 2 2 2 2 Domain of unknown function (DUF4874) CIA30 PF08547.12 ACT03883.1 - 0.027 14.5 0.0 12 5.8 0.0 2.6 2 0 0 2 2 2 0 Complex I intermediate-associated protein 30 (CIA30) BPD_transp_1 PF00528.22 ACT03884.1 - 2.8e-17 63.1 22.7 5.8e-16 58.8 18.5 2.0 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT03885.1 - 6.9e-15 55.3 23.3 6.9e-15 55.3 23.3 2.6 2 1 0 2 2 2 2 Binding-protein-dependent transport system inner membrane component SBP_bac_1 PF01547.25 ACT03886.1 - 1.6e-42 146.6 16.8 2.6e-42 145.9 16.8 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT03886.1 - 2.6e-38 132.4 15.9 3.8e-38 131.9 15.9 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT03886.1 - 1.4e-05 24.7 0.1 0.15 11.5 0.0 2.5 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT03886.1 - 0.00027 20.8 1.3 0.0094 15.7 1.3 2.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF4969 PF16339.5 ACT03886.1 - 0.001 19.3 0.0 0.0021 18.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4969) DUF4576 PF15144.6 ACT03886.1 - 0.0083 16.0 0.1 0.023 14.5 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4576) Glyco_hydro_31 PF01055.26 ACT03887.1 - 6.3e-49 167.3 0.0 2.7e-24 86.2 0.0 2.0 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 Melibiase PF02065.18 ACT03887.1 - 3.8e-06 26.1 0.1 6.4e-06 25.3 0.1 1.2 1 0 0 1 1 1 1 Melibiase Raffinose_syn PF05691.12 ACT03887.1 - 0.0012 16.8 0.2 0.0047 14.8 0.1 1.8 2 0 0 2 2 2 1 Raffinose synthase or seed imbibition protein Sip1 GFO_IDH_MocA PF01408.22 ACT03888.1 - 4.2e-23 82.5 0.0 7.1e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT03888.1 - 8.8e-08 32.2 0.0 1.8e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DUF4832 PF16116.5 ACT03889.1 - 7.7e-19 68.4 0.0 1.9e-18 67.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4832) fn3 PF00041.21 ACT03889.1 - 1.4e-14 54.1 10.1 4.6e-07 30.1 2.3 3.7 2 1 0 2 2 2 2 Fibronectin type III domain CBM_35 PF16990.5 ACT03889.1 - 4.9e-08 33.3 3.2 4.9e-08 33.3 3.2 2.4 2 0 0 2 2 2 1 Carbohydrate binding module (family 35) fn3_2 PF16893.5 ACT03889.1 - 6.3e-05 23.0 1.4 0.0052 16.9 0.3 2.9 2 0 0 2 2 2 1 Fibronectin type III domain RGI_lyase PF18370.1 ACT03889.1 - 0.00011 22.4 7.3 0.032 14.5 1.5 2.5 2 0 0 2 2 2 2 Rhamnogalacturonan I lyases beta-sheet domain CarbopepD_reg_2 PF13715.6 ACT03889.1 - 0.00024 21.0 0.1 0.026 14.5 0.1 2.8 2 0 0 2 2 2 1 CarboxypepD_reg-like domain DUF4874 PF16173.5 ACT03889.1 - 0.0078 15.9 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4874) Big_3 PF07523.12 ACT03889.1 - 0.02 15.2 0.1 0.16 12.3 0.1 2.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) CBM-like PF14683.6 ACT03889.1 - 0.023 14.6 2.8 0.08 12.8 0.2 3.3 3 1 0 3 3 3 0 Polysaccharide lyase family 4, domain III DUF4625 PF15418.6 ACT03889.1 - 0.04 14.2 0.0 0.25 11.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) MG2 PF01835.19 ACT03889.1 - 0.18 12.3 0.8 3.3 8.2 0.0 3.6 4 0 0 4 4 3 0 MG2 domain Big_3_3 PF13750.6 ACT03889.1 - 1.3 8.7 9.2 5.7 6.6 1.3 4.2 3 1 0 3 3 3 0 Bacterial Ig-like domain (group 3) Peripla_BP_3 PF13377.6 ACT03890.1 - 1.8e-30 106.4 0.0 3.9e-30 105.4 0.0 1.5 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT03890.1 - 4.8e-21 75.4 0.0 6.2e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT03890.1 - 3.3e-15 55.6 0.2 6.9e-15 54.6 0.2 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACT03890.1 - 3.5e-13 49.7 0.0 5.9e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_3 PF01381.22 ACT03890.1 - 4e-05 23.6 0.1 8.5e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix HTH_24 PF13412.6 ACT03890.1 - 0.0078 15.8 0.1 0.024 14.2 0.1 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 ACT03890.1 - 0.0094 15.9 0.1 0.026 14.4 0.1 1.8 1 0 0 1 1 1 1 MarR family HTH_23 PF13384.6 ACT03890.1 - 0.014 15.2 0.0 0.037 13.8 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain Sigma54_DBD PF04552.13 ACT03890.1 - 0.036 13.8 0.1 0.071 12.8 0.1 1.4 1 0 0 1 1 1 0 Sigma-54, DNA binding domain Sigma70_r4 PF04545.16 ACT03890.1 - 0.051 13.1 0.0 0.15 11.6 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 TnsD PF15978.5 ACT03890.1 - 0.052 12.5 0.1 0.085 11.8 0.1 1.2 1 0 0 1 1 1 0 Tn7-like transposition protein D HTH_19 PF12844.7 ACT03890.1 - 0.11 12.5 0.2 0.23 11.5 0.2 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 ACT03890.1 - 0.12 12.0 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_31 PF13560.6 ACT03890.1 - 0.14 12.5 0.0 0.28 11.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain DoxX PF07681.12 ACT03891.1 - 3.7e-17 62.7 13.9 3.7e-17 62.7 13.9 1.6 2 0 0 2 2 2 1 DoxX DoxX_2 PF13564.6 ACT03891.1 - 0.012 15.7 13.6 0.015 15.4 13.3 1.4 1 1 0 1 1 1 0 DoxX-like family DoxD PF04173.13 ACT03891.1 - 0.082 12.8 7.5 0.029 14.3 3.9 1.8 2 0 0 2 2 2 0 TQO small subunit DoxD DUF896 PF05979.12 ACT03892.1 - 4.8e-26 90.4 0.1 5.4e-26 90.2 0.1 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF896) DinB PF05163.12 ACT03894.1 - 2.3e-14 53.7 0.6 7.8e-14 52.0 0.6 1.7 1 1 0 1 1 1 1 DinB family DinB_2 PF12867.7 ACT03894.1 - 5.9e-08 33.3 0.2 9.6e-07 29.4 0.1 2.0 1 1 1 2 2 2 1 DinB superfamily DUF664 PF04978.12 ACT03894.1 - 5.2e-06 27.0 0.4 3e-05 24.5 0.4 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF664) Virul_fac_BrkB PF03631.15 ACT03895.1 - 3.7e-74 249.6 22.2 4.6e-74 249.3 22.2 1.0 1 0 0 1 1 1 1 Virulence factor BrkB ACDC PF14733.6 ACT03895.1 - 0.015 15.6 0.0 0.028 14.7 0.0 1.3 1 0 0 1 1 1 0 AP2-coincident C-terminal RDD PF06271.12 ACT03896.1 - 8.4e-16 58.4 7.1 1e-15 58.2 7.1 1.1 1 0 0 1 1 1 1 RDD family PPK2 PF03976.14 ACT03897.1 - 1.6e-71 240.4 0.2 2.4e-71 239.9 0.2 1.2 1 0 0 1 1 1 1 Polyphosphate kinase 2 (PPK2) dNK PF01712.19 ACT03897.1 - 0.0089 15.9 0.3 0.015 15.2 0.3 1.3 1 0 0 1 1 1 1 Deoxynucleoside kinase APS_kinase PF01583.20 ACT03897.1 - 0.16 11.9 0.0 3.6 7.5 0.0 2.1 2 0 0 2 2 2 0 Adenylylsulphate kinase TelA PF05816.11 ACT03898.1 - 1.4e-72 244.5 11.1 2.1e-72 244.0 11.1 1.2 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) NCD2 PF04905.13 ACT03898.1 - 0.089 12.8 0.5 0.31 11.0 0.0 2.0 2 0 0 2 2 2 0 NAB conserved region 2 (NCD2) DUF148 PF02520.17 ACT03898.1 - 0.47 10.6 8.8 0.53 10.4 0.1 3.3 3 1 1 4 4 4 0 Domain of unknown function DUF148 DUF2120 PF09893.9 ACT03898.1 - 1.5 8.9 8.1 0.86 9.7 0.7 3.2 2 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) VWA PF00092.28 ACT03899.1 - 4.6e-19 69.3 0.4 9.6e-19 68.3 0.4 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain SBP_bac_11 PF13531.6 ACT03899.1 - 1.6e-14 54.2 0.1 2.7e-14 53.5 0.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein VWA_2 PF13519.6 ACT03899.1 - 8.2e-12 45.7 0.0 2.2e-11 44.3 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ACT03899.1 - 0.028 14.4 0.0 0.063 13.2 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain PAS_3 PF08447.12 ACT03901.1 - 0.098 13.0 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 PAS fold NUDIX PF00293.28 ACT03902.1 - 5.5e-18 65.3 0.2 7.3e-18 64.9 0.2 1.1 1 0 0 1 1 1 1 NUDIX domain Hydrolase_2 PF07486.12 ACT03904.1 - 3.8e-16 59.8 0.0 4.7e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Cell Wall Hydrolase ABC2_membrane_3 PF12698.7 ACT03905.1 - 2e-53 181.7 19.9 2.3e-53 181.5 19.9 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 ACT03905.1 - 0.00069 19.1 21.4 0.00069 19.1 21.4 2.6 2 1 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 ACT03906.1 - 4.7e-26 91.9 0.0 9e-26 91.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter DUF4162 PF13732.6 ACT03906.1 - 7.8e-18 65.0 0.1 1.9e-17 63.7 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_21 PF13304.6 ACT03906.1 - 1.6e-06 28.2 0.1 0.021 14.7 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT03906.1 - 0.00081 18.9 0.0 0.041 13.3 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ACT03906.1 - 0.0017 18.6 0.0 0.0037 17.5 0.0 1.7 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit MukB PF04310.12 ACT03906.1 - 0.0069 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 MukB N-terminal AAA_22 PF13401.6 ACT03906.1 - 0.019 15.2 0.3 0.18 12.1 0.3 2.2 1 1 0 1 1 1 0 AAA domain AAA_27 PF13514.6 ACT03906.1 - 0.022 14.3 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ACT03906.1 - 0.024 14.3 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT03906.1 - 0.029 14.8 0.0 0.057 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 ACT03906.1 - 0.066 13.7 0.5 0.14 12.7 0.5 1.8 1 1 0 1 1 1 0 AAA domain DUF3584 PF12128.8 ACT03906.1 - 0.13 9.8 0.1 0.22 9.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) STAS PF01740.21 ACT03906.1 - 0.15 11.7 0.1 0.74 9.5 0.0 2.1 2 1 0 2 2 2 0 STAS domain AAA_30 PF13604.6 ACT03906.1 - 0.17 11.6 0.4 0.63 9.7 0.2 2.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ACT03907.1 - 1.9e-23 83.5 0.0 2.7e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT03907.1 - 5.2e-15 56.0 1.8 8.3e-09 35.7 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT03907.1 - 5e-05 22.8 0.0 0.0022 17.5 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ACT03907.1 - 0.0019 18.0 0.1 0.0037 17.0 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ACT03907.1 - 0.0028 18.2 0.0 0.004 17.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT03907.1 - 0.0032 17.2 0.0 0.0072 16.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ACT03907.1 - 0.082 13.2 0.0 0.29 11.4 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_27 PF13514.6 ACT03907.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ACT03907.1 - 0.11 12.8 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 ACT03907.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 ACT03907.1 - 0.16 12.1 0.0 0.5 10.4 0.0 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain GntR PF00392.21 ACT03908.1 - 6.2e-17 61.0 2.0 8.7e-17 60.5 0.4 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_Crp_2 PF13545.6 ACT03908.1 - 0.00019 21.4 0.3 0.0013 18.7 0.2 2.0 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_DeoR PF08220.12 ACT03908.1 - 0.00026 20.7 0.0 0.00062 19.5 0.0 1.6 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.20 ACT03908.1 - 0.00029 21.1 0.1 0.00036 20.8 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator HTH_36 PF13730.6 ACT03908.1 - 0.0047 16.8 0.0 0.0071 16.3 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 ACT03908.1 - 0.0064 16.5 0.0 0.011 15.8 0.0 1.5 1 1 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 ACT03908.1 - 0.0065 16.2 0.3 0.018 14.8 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_11 PF08279.12 ACT03908.1 - 0.0084 16.0 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 ACT03908.1 - 0.0091 15.5 0.2 0.018 14.6 0.2 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 ACT03908.1 - 0.012 15.7 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain RPA_C PF08784.11 ACT03908.1 - 0.015 15.9 0.0 0.035 14.8 0.0 1.6 1 1 1 2 2 2 0 Replication protein A C terminal Crp PF00325.20 ACT03908.1 - 0.052 13.2 0.2 0.16 11.7 0.1 1.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family Ribosomal_S19e PF01090.19 ACT03908.1 - 0.056 13.1 0.1 0.094 12.4 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein S19e SgrR_N PF12793.7 ACT03908.1 - 0.073 13.3 0.2 0.18 12.0 0.2 1.7 1 1 0 1 1 1 0 Sugar transport-related sRNA regulator N-term NUMOD1 PF07453.13 ACT03908.1 - 0.097 13.0 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 NUMOD1 domain Phage_holin_3_6 PF07332.11 ACT03909.1 - 0.0037 17.3 1.5 0.0037 17.3 1.5 3.2 2 1 1 3 3 3 2 Putative Actinobacterial Holin-X, holin superfamily III Hum_adeno_E3A PF05393.11 ACT03909.1 - 0.015 15.3 0.6 0.015 15.3 0.6 2.3 1 1 0 2 2 2 0 Human adenovirus early E3A glycoprotein DUF420 PF04238.12 ACT03910.1 - 1e-37 129.3 9.9 1.2e-37 129.1 9.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF420) DUF2306 PF10067.9 ACT03910.1 - 2.2e-09 37.7 7.5 2.6e-06 27.7 1.6 2.1 2 0 0 2 2 2 2 Predicted membrane protein (DUF2306) DUF3112 PF11309.8 ACT03910.1 - 0.0039 16.7 1.1 0.0039 16.7 1.1 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF3112) DUF2516 PF10724.9 ACT03910.1 - 0.022 15.0 1.9 0.022 15.0 1.9 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2516) Bax1-I PF01027.20 ACT03910.1 - 0.052 13.4 11.8 0.083 12.7 8.1 2.0 1 1 1 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 DUF373 PF04123.13 ACT03910.1 - 0.15 11.4 7.6 0.21 11.0 7.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF373) TMEM37 PF15108.6 ACT03910.1 - 0.17 11.7 3.4 0.36 10.7 3.4 1.8 1 1 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family DUF4231 PF14015.6 ACT03910.1 - 0.18 12.3 7.5 0.2 12.1 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DHHC PF01529.20 ACT03910.1 - 0.23 11.5 8.8 0.09 12.9 2.1 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase TctB PF07331.11 ACT03910.1 - 0.29 11.4 12.0 3.7 7.8 9.0 2.0 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family YesK PF14150.6 ACT03910.1 - 0.77 10.0 10.2 0.57 10.4 1.6 2.5 2 1 0 2 2 2 0 YesK-like protein Cation_ATPase_C PF00689.21 ACT03910.1 - 1.1 8.9 7.3 3.4 7.3 7.3 1.8 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus MerC PF03203.14 ACT03910.1 - 1.5 9.3 10.5 0.32 11.5 3.3 2.2 1 1 1 2 2 2 0 MerC mercury resistance protein Oxidored_q2 PF00420.24 ACT03910.1 - 1.5 8.4 9.3 0.8 9.4 5.8 2.3 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Tetraspanin PF00335.20 ACT03910.1 - 1.9 8.2 9.6 4.9 6.8 9.6 1.7 1 1 0 1 1 1 0 Tetraspanin family ABC2_membrane_5 PF13346.6 ACT03910.1 - 2.4 7.7 15.7 8.5 5.9 9.5 2.1 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF4131 PF13567.6 ACT03910.1 - 6 6.5 8.3 8.7 6.0 1.2 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4131) SdpI PF13630.6 ACT03910.1 - 6.5 7.0 13.2 5.3 7.3 2.2 2.3 2 0 0 2 2 2 0 SdpI/YhfL protein family Caa3_CtaG PF09678.10 ACT03911.1 - 1.2e-58 198.4 23.7 1.4e-58 198.1 23.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) COX4_pro PF03626.14 ACT03912.1 - 1e-12 48.3 13.9 1.2e-12 48.0 13.9 1.1 1 0 0 1 1 1 1 Prokaryotic Cytochrome C oxidase subunit IV CoatB PF10389.9 ACT03912.1 - 0.15 12.0 0.3 0.15 12.0 0.3 2.3 2 2 0 2 2 2 0 Bacteriophage coat protein B COX3 PF00510.18 ACT03913.1 - 9.1e-18 65.0 21.1 3.6e-17 63.1 21.1 1.7 1 1 0 1 1 1 1 Cytochrome c oxidase subunit III COX1 PF00115.20 ACT03914.1 - 7.6e-154 512.7 68.0 7.6e-154 512.7 68.0 2.2 2 1 0 2 2 2 1 Cytochrome C and Quinol oxidase polypeptide I Neurensin PF14927.6 ACT03914.1 - 1 9.0 0.0 1 9.0 0.0 3.3 3 0 0 3 3 3 0 Neurensin COX2 PF00116.20 ACT03915.1 - 1.7e-19 69.8 0.9 9.1e-18 64.3 0.0 2.3 1 1 1 2 2 2 1 Cytochrome C oxidase subunit II, periplasmic domain COX2_TM PF02790.15 ACT03915.1 - 5.1e-12 45.8 1.1 8.9e-12 45.0 1.1 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain Cytochrom_C PF00034.21 ACT03915.1 - 3e-08 34.7 0.0 6.6e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 ACT03915.1 - 0.00095 19.4 0.0 0.0027 18.0 0.0 1.8 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III DHHC PF01529.20 ACT03915.1 - 0.011 15.8 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase COX1 PF00115.20 ACT03915.1 - 0.033 13.1 0.5 0.04 12.8 0.5 1.1 1 0 0 1 1 1 0 Cytochrome C and Quinol oxidase polypeptide I RIFIN PF02009.16 ACT03915.1 - 0.19 11.6 0.8 0.32 10.9 0.8 1.3 1 0 0 1 1 1 0 Rifin FeoB_associated PF12669.7 ACT03915.1 - 0.24 11.8 5.3 0.2 12.1 1.6 2.5 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Orf78 PF06024.12 ACT03915.1 - 0.29 11.4 6.3 0.14 12.5 3.8 1.7 1 1 0 1 1 1 0 Orf78 (ac78) DUF2207 PF09972.9 ACT03915.1 - 3 6.5 6.0 12 4.5 0.1 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Spore_YhcN_YlaJ PF09580.10 ACT03916.1 - 1.1e-09 38.6 0.0 0.00078 19.6 0.0 2.3 2 0 0 2 2 2 2 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) MFS_1_like PF12832.7 ACT03917.1 - 3.5e-51 174.3 32.1 1.5e-50 172.2 32.1 1.8 1 1 0 1 1 1 1 MFS_1 like family Nuc_H_symport PF03825.16 ACT03917.1 - 2.3e-20 73.0 30.1 2.7e-20 72.7 30.1 1.0 1 0 0 1 1 1 1 Nucleoside H+ symporter MFS_1 PF07690.16 ACT03917.1 - 2.1e-17 63.1 54.0 2.2e-16 59.7 41.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 ACT03917.1 - 2e-10 40.0 26.5 2.9e-09 36.2 26.5 2.0 1 1 0 1 1 1 1 LacY proton/sugar symporter MFS_2 PF13347.6 ACT03917.1 - 0.0014 17.3 38.9 0.34 9.4 30.3 3.1 1 1 1 2 2 2 2 MFS/sugar transport protein Aldo_ket_red PF00248.21 ACT03918.1 - 7.9e-77 258.3 0.0 9e-77 258.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HxlR PF01638.17 ACT03919.1 - 3.7e-31 106.8 0.1 4.5e-31 106.5 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix Replic_Relax PF13814.6 ACT03919.1 - 0.024 14.7 0.0 0.025 14.6 0.0 1.1 1 0 0 1 1 1 0 Replication-relaxation LexA_DNA_bind PF01726.16 ACT03919.1 - 0.073 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 LexA DNA binding domain PadR PF03551.14 ACT03919.1 - 0.091 12.7 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family MarR PF01047.22 ACT03919.1 - 0.093 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 MarR family MerR PF00376.23 ACT03919.1 - 0.16 11.8 0.1 0.46 10.3 0.0 1.7 2 0 0 2 2 2 0 MerR family regulatory protein DUF4423 PF14394.6 ACT03919.1 - 0.19 11.4 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Spore_permease PF03845.13 ACT03920.1 - 2.5e-42 144.9 27.5 4.3e-42 144.1 27.5 1.3 1 0 0 1 1 1 1 Spore germination protein SRTM1 PF15872.5 ACT03920.1 - 0.067 13.3 0.5 0.067 13.3 0.5 2.8 3 0 0 3 3 3 0 Serine-rich and transmembrane domain-containing protein 1 PIRT PF15099.6 ACT03920.1 - 0.084 12.5 0.1 0.24 11.0 0.1 1.7 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Wzy_C PF04932.15 ACT03921.1 - 0.0035 17.0 5.5 0.0051 16.4 5.5 1.3 1 0 0 1 1 1 1 O-Antigen ligase DUF3413 PF11893.8 ACT03921.1 - 0.074 12.2 3.7 0.09 11.9 3.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) VIT1 PF01988.19 ACT03921.1 - 0.12 12.2 2.5 0.14 12.0 2.5 1.2 1 0 0 1 1 1 0 VIT family YfhO PF09586.10 ACT03921.1 - 0.19 9.9 4.9 0.23 9.7 4.9 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF1514 PF07438.11 ACT03921.1 - 0.22 11.4 3.1 4.7 7.2 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1514) DUF2976 PF11190.8 ACT03921.1 - 2.4 8.0 7.4 0.76 9.6 4.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2976) Spore_GerAC PF05504.11 ACT03922.1 - 1.2e-31 110.2 1.6 8.4e-31 107.4 1.1 2.0 2 0 0 2 2 2 1 Spore germination B3/ GerAC like, C-terminal LPD14 PF18827.1 ACT03922.1 - 0.066 13.5 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 14 BAR PF03114.18 ACT03922.1 - 0.072 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 BAR domain GerA PF03323.13 ACT03923.1 - 2.6e-192 639.4 3.1 3e-192 639.2 3.1 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein NMN_transporter PF04973.12 ACT03923.1 - 2.4 8.1 11.8 1.4 8.9 0.5 2.2 1 1 0 2 2 2 0 Nicotinamide mononucleotide transporter BPD_transp_1 PF00528.22 ACT03925.1 - 1.4e-07 31.4 29.4 4.8e-06 26.4 29.4 2.5 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT03926.1 - 9.9e-17 61.3 12.2 9.9e-17 61.3 12.2 2.1 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component SF3a60_bindingd PF12108.8 ACT03927.1 - 0.094 12.6 3.5 97 3.0 0.0 5.3 5 0 0 5 5 5 0 Splicing factor SF3a60 binding domain DUF3502 PF12010.8 ACT03927.1 - 0.47 11.1 0.1 0.47 11.1 0.1 3.4 4 1 0 4 4 4 0 Domain of unknown function (DUF3502) Response_reg PF00072.24 ACT03928.1 - 1.7e-25 89.4 0.0 3.5e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT03928.1 - 4.7e-16 58.8 1.2 9.3e-16 57.9 0.1 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03928.1 - 6.4e-14 51.6 0.3 6.7e-08 32.4 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT03928.1 - 5.2e-05 23.5 0.6 0.00024 21.3 0.4 2.4 2 1 0 2 2 2 1 GGDEF-like domain DEK_C PF08766.11 ACT03928.1 - 0.3 11.1 0.9 5.9 6.9 0.1 3.0 3 0 0 3 3 3 0 DEK C terminal domain His_kinase PF06580.13 ACT03929.1 - 6.9e-23 80.8 1.1 2.1e-22 79.2 1.1 1.9 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT03929.1 - 1.4e-07 31.5 1.7 2.5e-07 30.7 1.7 1.4 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT03929.1 - 1.8e-07 31.6 0.0 3.9e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT03929.1 - 1.6e-06 28.4 0.2 4.8e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 HAMP domain HATPase_c_2 PF13581.6 ACT03929.1 - 0.0047 16.9 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain DUF948 PF06103.11 ACT03929.1 - 0.09 13.0 0.3 1.7 9.0 0.0 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Response_reg PF00072.24 ACT03930.1 - 2.1e-24 85.9 0.0 4.3e-24 84.8 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT03930.1 - 1.2e-16 60.8 0.0 2.9e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03930.1 - 5.1e-10 39.2 2.2 2.2e-05 24.4 0.1 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Talin_middle PF09141.10 ACT03930.1 - 0.1 12.6 0.3 17 5.4 0.0 2.4 2 0 0 2 2 2 0 Talin, middle domain HTH_18 PF12833.7 ACT03931.1 - 5.9e-18 64.9 0.2 1e-17 64.1 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03931.1 - 4.5e-13 48.9 0.1 5.4e-07 29.6 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT03931.1 - 6.9e-13 48.7 0.4 1.9e-12 47.3 0.1 1.8 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT03931.1 - 6.9e-10 38.5 0.0 1.3e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Cupin domain DUF4863 PF16155.5 ACT03931.1 - 0.012 15.5 0.1 0.023 14.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4863) HTH_3 PF01381.22 ACT03931.1 - 0.03 14.4 0.0 0.093 12.8 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix DUF3253 PF11625.8 ACT03931.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3253) GTP_cyclohydro2 PF00925.20 ACT03932.1 - 1e-45 155.3 0.0 1.3e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II Hydrolase_6 PF13344.6 ACT03932.1 - 0.0087 16.2 0.0 0.025 14.7 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HMA PF00403.26 ACT03934.1 - 6.6e-14 52.1 1.7 9.5e-14 51.6 1.7 1.3 1 1 0 1 1 1 1 Heavy-metal-associated domain Linker_histone PF00538.19 ACT03934.1 - 0.069 13.5 0.1 7.1 7.1 0.0 2.1 2 0 0 2 2 2 0 linker histone H1 and H5 family Fer2_BFD PF04324.15 ACT03934.1 - 0.074 13.4 0.6 3.3 8.2 0.1 2.2 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain Trns_repr_metal PF02583.17 ACT03935.1 - 1.6e-29 102.1 1.1 1.6e-29 102.1 1.1 1.6 2 0 0 2 2 2 1 Metal-sensitive transcriptional repressor Chromadorea_ALT PF05535.12 ACT03935.1 - 0.0015 18.6 0.7 4.2 7.6 0.0 3.0 2 1 1 3 3 3 2 Chromadorea ALT protein MitMem_reg PF13012.6 ACT03935.1 - 0.0079 16.6 0.7 0.0094 16.4 0.7 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function GDPD PF03009.17 ACT03936.1 - 1.1e-47 163.0 0.0 1.5e-47 162.5 0.0 1.2 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ACT03936.1 - 0.0001 22.6 0.0 0.00079 19.8 0.0 2.4 3 0 0 3 3 3 1 Glycerophosphoryl diester phosphodiesterase family YitT_membrane PF02588.15 ACT03937.1 - 1e-68 230.8 24.8 1.2e-68 230.5 24.8 1.1 1 0 0 1 1 1 1 Uncharacterised 5xTM membrane BCR, YitT family COG1284 DUF2179 PF10035.9 ACT03937.1 - 3.2e-21 74.8 1.5 7.4e-21 73.6 0.2 2.3 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2179) Vma12 PF11712.8 ACT03937.1 - 0.2 11.7 0.9 0.47 10.5 0.9 1.7 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase FUSC_2 PF13515.6 ACT03937.1 - 0.88 9.7 19.6 0.22 11.6 7.7 2.9 1 1 1 2 2 2 0 Fusaric acid resistance protein-like Peripla_BP_4 PF13407.6 ACT03938.1 - 2.9e-56 190.9 12.8 3.7e-56 190.6 12.8 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACT03938.1 - 1.3e-15 57.6 0.6 1.6e-15 57.3 0.6 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 ACT03938.1 - 9.3e-11 42.3 0.1 1.7e-06 28.4 0.0 2.1 1 1 1 2 2 2 2 Periplasmic binding protein-like domain Peripla_BP_6 PF13458.6 ACT03938.1 - 1.8e-05 24.6 6.6 5.7e-05 22.9 6.7 1.7 1 1 0 1 1 1 1 Periplasmic binding protein Lipid_DES PF08557.10 ACT03938.1 - 0.069 12.7 0.1 0.44 10.1 0.0 2.1 2 0 0 2 2 2 0 Sphingolipid Delta4-desaturase (DES) TFA2_Winged_2 PF18121.1 ACT03938.1 - 0.15 11.8 0.0 0.78 9.5 0.0 2.2 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 BPD_transp_2 PF02653.16 ACT03939.1 - 9.1e-53 179.1 39.3 9.1e-53 179.1 39.3 1.4 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component ABC_tran PF00005.27 ACT03940.1 - 2.9e-51 173.6 0.0 7.7e-29 101.0 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ACT03940.1 - 5.6e-07 29.7 0.1 0.15 11.8 0.0 3.4 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 ACT03940.1 - 6.7e-05 22.7 0.3 0.0003 20.6 0.2 2.2 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ACT03940.1 - 9.9e-05 22.3 0.1 0.023 14.6 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 ACT03940.1 - 0.0006 20.4 0.0 0.0013 19.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT03940.1 - 0.0017 18.0 0.1 0.0051 16.5 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 ACT03940.1 - 0.0097 15.4 0.4 0.67 9.4 0.0 2.5 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ACT03940.1 - 0.01 15.6 0.0 0.014 15.2 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 ACT03940.1 - 0.015 15.3 0.2 4.6 7.3 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ploopntkinase3 PF18751.1 ACT03940.1 - 0.018 14.9 0.0 0.045 13.7 0.0 1.6 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 FeoB_N PF02421.18 ACT03940.1 - 0.038 13.5 0.7 0.077 12.5 0.7 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_27 PF13514.6 ACT03940.1 - 0.041 13.5 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ACT03940.1 - 0.043 14.1 1.7 1 9.6 1.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ACT03940.1 - 0.055 13.8 0.1 0.44 10.9 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 ACT03940.1 - 0.088 12.9 0.1 0.55 10.3 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_25 PF13481.6 ACT03940.1 - 0.1 12.2 0.1 1 8.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ACT03940.1 - 0.12 11.6 0.1 1 8.6 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 ACT03940.1 - 0.48 10.1 2.1 20 4.9 0.0 3.4 4 0 0 4 4 4 0 IstB-like ATP binding protein Peripla_BP_4 PF13407.6 ACT03941.1 - 5e-60 203.2 1.1 6.1e-60 203.0 1.1 1.1 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 ACT03941.1 - 3.7e-19 69.2 0.1 4.6e-19 68.9 0.1 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_6 PF13458.6 ACT03941.1 - 2.8e-06 27.3 1.4 0.0014 18.3 1.0 2.2 1 1 0 2 2 2 2 Periplasmic binding protein ATPgrasp_N PF18130.1 ACT03941.1 - 0.0014 19.1 0.1 0.41 11.2 0.0 3.0 3 1 0 3 3 3 1 ATP-grasp N-terminal domain CoA_binding_2 PF13380.6 ACT03941.1 - 0.087 13.3 0.1 0.23 12.0 0.1 1.7 1 0 0 1 1 1 0 CoA binding domain TPR_2 PF07719.17 ACT03941.1 - 0.12 12.6 0.0 0.4 10.9 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat dCache_1 PF02743.18 ACT03942.1 - 7.3e-38 130.8 5.5 1.3e-37 130.0 5.5 1.4 1 0 0 1 1 1 1 Cache domain His_kinase PF06580.13 ACT03942.1 - 9.1e-26 90.0 1.7 1.8e-25 89.0 0.2 2.4 2 0 0 2 2 2 1 Histidine kinase HAMP PF00672.25 ACT03942.1 - 5.1e-12 46.0 0.0 1.7e-11 44.3 0.0 2.0 2 0 0 2 2 2 1 HAMP domain HATPase_c PF02518.26 ACT03942.1 - 8e-09 36.0 0.1 1.4e-07 32.0 0.0 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_2 PF08269.11 ACT03942.1 - 0.00014 21.1 0.2 0.00014 21.1 0.2 1.9 2 0 0 2 2 2 1 Cache domain Cache_3-Cache_2 PF17201.4 ACT03942.1 - 0.0004 19.7 0.1 0.001 18.4 0.1 1.6 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain sCache_2 PF17200.4 ACT03942.1 - 0.001 18.9 2.7 0.0027 17.6 0.3 2.9 2 1 0 2 2 2 1 Single Cache domain 2 DUF4179 PF13786.6 ACT03942.1 - 0.022 15.2 2.1 25 5.4 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) sCache_3_2 PF17203.4 ACT03942.1 - 0.043 14.0 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 Single cache domain 3 sCache_like PF16736.5 ACT03942.1 - 0.06 13.4 0.9 0.17 12.0 0.1 2.2 2 0 0 2 2 2 0 Single Cache-like HATPase_c_5 PF14501.6 ACT03942.1 - 0.069 13.1 0.0 0.37 10.7 0.0 2.2 2 0 0 2 2 2 0 GHKL domain HATPase_c_2 PF13581.6 ACT03942.1 - 0.099 12.6 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 ACT03942.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cytidylate_kin PF02224.18 ACT03942.1 - 0.73 9.5 3.9 0.75 9.5 2.3 1.8 2 0 0 2 2 2 0 Cytidylate kinase LapA_dom PF06305.11 ACT03942.1 - 5.4 6.9 7.8 0.48 10.3 0.2 2.7 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Response_reg PF00072.24 ACT03943.1 - 4.6e-26 91.2 0.0 1e-25 90.1 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT03943.1 - 1.5e-22 79.7 0.9 5e-22 78.0 0.9 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03943.1 - 2.9e-18 65.5 1.4 1.8e-08 34.3 0.1 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT03943.1 - 4.7e-12 46.2 0.8 1.5e-11 44.6 0.4 2.1 2 0 0 2 2 2 1 GGDEF-like domain IMS PF00817.20 ACT03943.1 - 0.0011 19.0 0.8 0.037 14.0 0.0 2.9 2 2 0 2 2 2 1 impB/mucB/samB family FmdA_AmdA PF03069.15 ACT03943.1 - 0.042 12.7 0.0 0.076 11.9 0.0 1.4 1 0 0 1 1 1 0 Acetamidase/Formamidase family Nup54 PF13874.6 ACT03943.1 - 9.2 6.4 7.7 1.1 9.3 2.8 2.1 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 PaaX_C PF08223.11 ACT03944.1 - 6.2e-10 39.2 0.1 1.4e-09 38.1 0.1 1.6 1 0 0 1 1 1 1 PaaX-like protein C-terminal domain PaaX PF07848.12 ACT03944.1 - 5.6e-06 26.5 0.1 1.3e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 PaaX-like protein CRISPR_Cas2 PF09827.9 ACT03944.1 - 0.0014 18.8 0.0 0.0034 17.5 0.0 1.7 1 0 0 1 1 1 1 CRISPR associated protein Cas2 GntR PF00392.21 ACT03944.1 - 0.0017 18.0 0.1 0.0033 17.1 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Mrr_N PF14338.6 ACT03944.1 - 0.045 13.9 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Mrr N-terminal domain Mem_trans PF03547.18 ACT03945.1 - 6e-15 54.5 28.4 2.8e-11 42.4 14.4 2.0 1 1 1 2 2 2 2 Membrane transport protein ATPase_gene1 PF09527.10 ACT03945.1 - 0.35 11.0 0.2 0.35 11.0 0.2 3.6 3 1 0 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter DAO PF01266.24 ACT03946.1 - 2.4e-49 168.8 0.2 3.4e-49 168.3 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 ACT03946.1 - 5.4e-21 74.8 0.0 1.1e-20 73.8 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 ACT03946.1 - 7.6e-05 22.0 1.5 0.026 13.6 0.5 2.4 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 ACT03946.1 - 0.0017 17.8 2.0 0.0038 16.6 1.2 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ACT03946.1 - 0.0091 15.3 0.9 0.074 12.3 0.9 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ACT03946.1 - 0.012 14.8 0.2 0.023 13.9 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ACT03946.1 - 0.016 15.5 2.7 0.12 12.6 1.0 2.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FGGY_N PF00370.21 ACT03947.1 - 6.6e-81 271.5 0.1 8.8e-81 271.1 0.1 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ACT03947.1 - 1e-66 224.4 0.2 2.8e-66 223.0 0.2 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 ACT03947.1 - 0.0091 15.5 0.0 1.2 8.6 0.0 2.2 2 1 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family AnmK PF03702.14 ACT03947.1 - 0.017 14.2 0.0 0.49 9.4 0.0 2.1 2 0 0 2 2 2 0 Anhydro-N-acetylmuramic acid kinase Aldedh PF00171.22 ACT03948.1 - 3.4e-154 513.8 0.1 4.1e-154 513.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pro_dh PF01619.18 ACT03949.1 - 4.3e-30 105.3 2.0 1.4e-29 103.6 2.0 1.7 1 1 0 1 1 1 1 Proline dehydrogenase Iso_dh PF00180.20 ACT03949.1 - 0.1 11.7 0.1 0.14 11.2 0.1 1.1 1 0 0 1 1 1 0 Isocitrate/isopropylmalate dehydrogenase EAL PF00563.20 ACT03949.1 - 0.12 11.8 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 EAL domain Peptidase_M24 PF00557.24 ACT03950.1 - 4.8e-62 209.3 0.8 8.8e-62 208.5 0.8 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 ACT03950.1 - 3.2e-21 76.4 0.0 5.3e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain DUF2623 PF11115.8 ACT03950.1 - 0.029 14.5 0.0 0.07 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2623) Peptidase_M29 PF02073.15 ACT03951.1 - 1.3e-166 554.4 0.0 1.5e-166 554.2 0.0 1.0 1 0 0 1 1 1 1 Thermophilic metalloprotease (M29) Glyco_transf_8C PF08437.10 ACT03952.1 - 0.02 15.0 0.5 0.026 14.6 0.1 1.4 2 0 0 2 2 2 0 Glycosyl transferase family 8 C-terminal Ribosomal_L4 PF00573.22 ACT03953.1 - 0.058 13.1 0.3 0.062 13.0 0.3 1.1 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family DinB PF05163.12 ACT03955.1 - 2.1e-31 109.1 0.2 2.8e-31 108.7 0.2 1.1 1 0 0 1 1 1 1 DinB family DinB_2 PF12867.7 ACT03955.1 - 1.9e-11 44.5 0.2 2.3e-11 44.3 0.2 1.1 1 0 0 1 1 1 1 DinB superfamily DUF664 PF04978.12 ACT03955.1 - 5.3e-07 30.2 0.4 7.1e-07 29.7 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF664) COP23 PF14218.6 ACT03955.1 - 0.12 12.1 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Circadian oscillating protein COP23 PspA_IM30 PF04012.12 ACT03956.1 - 3.5e-51 173.9 39.2 4e-51 173.7 39.2 1.0 1 0 0 1 1 1 1 PspA/IM30 family PRKG1_interact PF15898.5 ACT03956.1 - 0.01 16.7 8.6 0.01 16.7 8.6 2.6 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain CHDCT2 PF08074.11 ACT03956.1 - 0.67 10.1 10.9 0.26 11.4 6.7 2.0 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain Occludin_ELL PF07303.13 ACT03956.1 - 1.4 9.7 15.3 0.16 12.7 3.3 2.9 1 1 2 3 3 3 0 Occludin homology domain V_ATPase_I PF01496.19 ACT03956.1 - 3.3 5.5 17.6 10 3.9 16.7 1.8 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Spot_14 PF07084.12 ACT03956.1 - 5.4 7.1 9.4 0.46 10.6 4.7 1.6 2 0 0 2 2 2 0 Thyroid hormone-inducible hepatic protein Spot 14 DUF350 PF03994.14 ACT03957.1 - 1.2e-10 41.4 10.4 1.2e-07 31.7 0.1 2.2 2 0 0 2 2 2 2 Domain of Unknown Function (DUF350) DUF4178 PF13785.6 ACT03958.1 - 3.6e-27 95.2 0.3 4.1e-27 95.0 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4178) Phage_RpbA PF10789.9 ACT03958.1 - 0.087 12.9 0.2 0.27 11.3 0.1 1.9 1 1 1 2 2 2 0 Phage RNA polymerase binding, RpbA DUF4247 PF14042.6 ACT03959.1 - 1.6e-36 125.7 3.6 2.8e-36 125.0 3.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4247) DrrA_P4M PF14860.6 ACT03960.1 - 0.17 11.8 2.8 21 5.0 0.1 3.2 3 0 0 3 3 3 0 DrrA phosphatidylinositol 4-phosphate binding domain DUF3502 PF12010.8 ACT03960.1 - 1.3 9.6 4.4 1 10.0 0.5 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF3502) BPD_transp_1 PF00528.22 ACT03961.1 - 3.9e-14 52.8 22.7 3.6e-13 49.7 22.7 2.2 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Bac_export_2 PF01312.19 ACT03961.1 - 0.81 8.8 3.8 0.47 9.6 0.2 2.0 1 1 0 2 2 2 0 FlhB HrpN YscU SpaS Family BPD_transp_1 PF00528.22 ACT03962.1 - 1.2e-15 57.7 10.0 1.2e-15 57.7 10.0 1.6 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Ldh_1_N PF00056.23 ACT03963.1 - 9e-32 110.1 0.0 1.3e-31 109.6 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 ACT03963.1 - 9.2e-24 84.2 0.0 1.3e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain F420_oxidored PF03807.17 ACT03963.1 - 7.2e-05 23.3 0.0 0.00017 22.1 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 ACT03963.1 - 0.00015 21.8 0.0 0.0003 20.8 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 ACT03963.1 - 0.025 14.2 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 ACT03963.1 - 0.064 13.5 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 ACT03963.1 - 0.16 12.4 0.0 0.29 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Thioredoxin PF00085.20 ACT03964.1 - 1.4e-12 47.4 0.0 1.6e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 ACT03964.1 - 0.019 14.9 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.10 ACT03964.1 - 0.089 12.5 0.0 0.092 12.5 0.0 1.2 1 0 0 1 1 1 0 Redoxin Thioredoxin_7 PF13899.6 ACT03964.1 - 0.092 12.9 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like Cytochrom_C PF00034.21 ACT03964.1 - 0.11 13.7 0.0 0.7 11.1 0.0 2.0 2 0 0 2 2 2 0 Cytochrome c tRNA-synt_1d PF00750.19 ACT03965.1 - 4e-91 305.5 0.0 5e-91 305.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 ACT03965.1 - 3.7e-31 107.8 0.6 7.6e-31 106.8 0.6 1.6 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 ACT03965.1 - 7.1e-12 45.8 0.1 2e-11 44.3 0.0 1.9 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1g PF09334.11 ACT03965.1 - 5.8e-05 22.0 0.0 0.014 14.1 0.0 3.1 3 0 0 3 3 3 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ACT03965.1 - 0.031 13.6 0.0 2.3 7.5 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain HemN_C PF06969.16 ACT03965.1 - 0.035 14.2 0.0 0.1 12.7 0.0 1.7 1 0 0 1 1 1 0 HemN C-terminal domain AvrM-A PF18241.1 ACT03965.1 - 0.11 12.9 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 Flax-rust effector AvrM-A NUDIX PF00293.28 ACT03966.1 - 4.5e-13 49.4 0.0 5.2e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain ABC2_membrane_3 PF12698.7 ACT03967.1 - 1.1 8.3 16.8 1.3 8.1 16.8 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein Cytochrom_B561 PF03188.16 ACT03968.1 - 0.06 13.5 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 Staphostatin_A PF09022.10 ACT03968.1 - 0.07 13.0 0.1 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 Staphostatin A Bac_luciferase PF00296.20 ACT03970.1 - 6.5e-32 111.2 0.1 1.2e-31 110.3 0.1 1.4 1 1 0 1 1 1 1 Luciferase-like monooxygenase adh_short_C2 PF13561.6 ACT03971.1 - 9.5e-69 231.5 0.2 1.1e-68 231.3 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT03971.1 - 2.4e-53 180.5 0.1 2.8e-53 180.3 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT03971.1 - 1.1e-08 35.1 0.3 1.7e-08 34.6 0.3 1.1 1 0 0 1 1 1 1 KR domain DUF2620 PF10941.8 ACT03971.1 - 0.016 15.4 0.7 0.032 14.4 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF2620 Epimerase PF01370.21 ACT03971.1 - 0.045 13.2 0.1 0.066 12.7 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 ACT03971.1 - 0.15 11.9 1.3 0.22 11.4 1.3 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HhH-GPD PF00730.25 ACT03972.1 - 6.5e-13 49.1 0.0 1.2e-12 48.3 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein OGG_N PF07934.12 ACT03972.1 - 1.2e-06 28.6 0.0 1.8e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain AlkA_N PF06029.11 ACT03972.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 AlkA N-terminal domain Ada_Zn_binding PF02805.16 ACT03973.1 - 1.7e-27 95.2 0.4 2.5e-27 94.7 0.4 1.3 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_18 PF12833.7 ACT03973.1 - 1.1e-26 92.9 0.7 2.7e-26 91.6 0.2 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT03973.1 - 3.3e-21 74.8 1.9 4.2e-10 39.5 0.0 2.7 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF1409 PF07197.12 ACT03973.1 - 0.00079 19.3 0.6 0.085 12.7 0.1 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF1409) FAM91_N PF14647.6 ACT03973.1 - 0.0024 17.2 0.1 0.0031 16.8 0.1 1.1 1 0 0 1 1 1 1 FAM91 N-terminus Sigma70_r4 PF04545.16 ACT03973.1 - 0.008 15.7 0.0 0.024 14.2 0.0 1.8 1 0 0 1 1 1 1 Sigma-70, region 4 UCR_14kD PF02271.16 ACT03973.1 - 0.059 13.4 1.2 0.47 10.4 0.3 2.2 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase complex 14kD subunit ArsD PF06953.11 ACT03973.1 - 0.076 13.4 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Arsenical resistance operon trans-acting repressor ArsD CAP_GLY PF01302.25 ACT03973.1 - 0.086 12.9 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 CAP-Gly domain TraE PF05309.11 ACT03973.1 - 0.087 12.2 0.1 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 TraE protein HTH_23 PF13384.6 ACT03973.1 - 0.1 12.5 0.1 2.3 8.1 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain DUF2063 PF09836.9 ACT03973.1 - 0.1 12.8 0.1 0.28 11.5 0.1 1.8 1 1 0 1 1 1 0 Putative DNA-binding domain MarR_2 PF12802.7 ACT03973.1 - 0.13 12.1 0.1 0.6 10.0 0.0 2.1 2 0 0 2 2 2 0 MarR family DNA_binding_1 PF01035.20 ACT03974.1 - 1.4e-29 102.0 0.1 5.9e-29 100.0 0.0 1.8 2 0 0 2 2 2 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.15 ACT03974.1 - 5.1e-10 40.0 0.1 7.2e-10 39.5 0.1 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Thr_synth_N PF14821.6 ACT03975.1 - 1.3e-26 92.5 0.0 3.4e-26 91.2 0.0 1.8 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 ACT03975.1 - 2.2e-18 66.7 0.0 5.7e-18 65.4 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF2997 PF11211.8 ACT03975.1 - 0.094 12.5 0.8 0.24 11.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2997) Glyco_transf_28 PF03033.20 ACT03976.1 - 1.2e-38 132.2 0.0 2.2e-38 131.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_tran_28_C PF04101.16 ACT03976.1 - 4.8e-32 111.2 0.0 8.1e-32 110.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.6 ACT03976.1 - 4e-06 26.3 0.0 8.8e-06 25.2 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 1 Glyco_trans_4_2 PF13477.6 ACT03976.1 - 0.00029 20.9 0.0 0.00061 19.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like UDPGT PF00201.18 ACT03976.1 - 0.0024 16.8 0.0 0.0033 16.3 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_4 PF13439.6 ACT03976.1 - 0.0053 16.8 0.0 0.0088 16.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 DUF4760 PF15956.5 ACT03976.1 - 0.098 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4760) Alg14 PF08660.11 ACT03976.1 - 0.19 11.7 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like HTH_20 PF12840.7 ACT03977.1 - 4.6e-15 55.4 0.2 6.8e-15 54.9 0.2 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 ACT03977.1 - 5.3e-12 45.4 0.1 7.9e-12 44.9 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 ACT03977.1 - 2.2e-05 24.2 0.3 4e-05 23.4 0.3 1.4 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 ACT03977.1 - 0.00018 21.3 0.3 0.00027 20.8 0.3 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 ACT03977.1 - 0.00054 19.5 0.0 0.001 18.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 ACT03977.1 - 0.0011 19.2 0.0 0.0017 18.7 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator RP-C PF03428.13 ACT03977.1 - 0.0023 17.6 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 Replication protein C N-terminal domain HTH_IclR PF09339.10 ACT03977.1 - 0.0027 17.4 0.0 0.0043 16.8 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_11 PF08279.12 ACT03977.1 - 0.0099 15.8 0.1 0.017 15.1 0.1 1.3 1 0 0 1 1 1 1 HTH domain HTH_27 PF13463.6 ACT03977.1 - 0.01 16.3 0.1 0.015 15.8 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_Crp_2 PF13545.6 ACT03977.1 - 0.013 15.5 0.1 0.019 14.9 0.1 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_34 PF13601.6 ACT03977.1 - 0.036 14.2 0.1 0.063 13.5 0.0 1.5 2 0 0 2 2 2 0 Winged helix DNA-binding domain GntR PF00392.21 ACT03977.1 - 0.044 13.4 0.2 0.083 12.6 0.2 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Penicillinase_R PF03965.16 ACT03977.1 - 0.052 13.9 0.2 0.11 12.9 0.2 1.7 1 1 0 1 1 1 0 Penicillinase repressor HTH_28 PF13518.6 ACT03977.1 - 0.057 13.6 0.0 0.057 13.6 0.0 1.7 2 0 0 2 2 1 0 Helix-turn-helix domain FUR PF01475.19 ACT03977.1 - 0.064 13.4 0.0 0.093 12.9 0.0 1.3 1 0 0 1 1 1 0 Ferric uptake regulator family Cdc6_C PF09079.11 ACT03977.1 - 0.12 12.4 0.1 0.24 11.4 0.0 1.5 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain AHSA1 PF08327.11 ACT03978.1 - 7.9e-19 68.1 0.8 1e-18 67.8 0.8 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ACT03978.1 - 1.2e-07 32.1 0.8 1.8e-07 31.5 0.8 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF4493 PF14900.6 ACT03978.1 - 0.092 12.6 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4493) GSDH PF07995.11 ACT03979.1 - 4.4e-67 226.8 0.1 5.8e-67 226.4 0.1 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase NHL PF01436.21 ACT03979.1 - 0.0016 18.4 0.6 33 4.7 0.0 5.0 5 0 0 5 5 5 1 NHL repeat SGL PF08450.12 ACT03979.1 - 0.047 13.3 0.0 1.9 8.0 0.0 2.4 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region PQQ_3 PF13570.6 ACT03979.1 - 0.2 12.2 4.7 11 6.6 0.1 3.5 4 0 0 4 4 4 0 PQQ-like domain YlbE PF14003.6 ACT03980.1 - 0.0037 17.7 0.1 0.0093 16.4 0.1 1.6 1 0 0 1 1 1 1 YlbE-like protein SmpA_OmlA PF04355.13 ACT03980.1 - 0.028 14.2 0.1 0.1 12.4 0.1 2.0 1 1 0 1 1 1 0 SmpA / OmlA family Sigma70_r4_2 PF08281.12 ACT03981.1 - 4.9e-14 51.7 0.2 8e-14 51.1 0.2 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACT03981.1 - 5.9e-14 51.6 0.3 1.2e-13 50.6 0.3 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 ACT03981.1 - 1.3e-08 34.2 0.3 4.7e-08 32.4 0.2 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 GerE PF00196.19 ACT03981.1 - 2.9e-05 23.5 0.1 6.6e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_24 PF13412.6 ACT03981.1 - 0.036 13.6 0.0 0.066 12.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Sigma70_ECF PF07638.11 ACT03981.1 - 0.079 12.9 0.2 0.11 12.4 0.2 1.4 1 0 0 1 1 1 0 ECF sigma factor DUF2306 PF10067.9 ACT03982.1 - 1e-36 126.4 13.4 1.4e-36 125.9 13.4 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2306) DUF420 PF04238.12 ACT03982.1 - 0.00016 22.0 18.7 0.016 15.5 8.1 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF420) EXS PF03124.14 ACT03982.1 - 0.00091 18.6 5.2 0.0013 18.2 5.2 1.1 1 0 0 1 1 1 1 EXS family DUF1686 PF07937.11 ACT03982.1 - 0.0011 18.9 1.2 0.0011 18.9 1.2 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1686) DUF4728 PF15860.5 ACT03982.1 - 5.9 7.6 11.7 5.4 7.8 7.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4728) DUF3165 PF11364.8 ACT03982.1 - 5.9 7.3 13.1 0.15 12.4 1.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3165) DUF72 PF01904.18 ACT03983.1 - 4.5e-60 203.5 0.2 5.1e-60 203.3 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 Aminotran_1_2 PF00155.21 ACT03984.1 - 1.9e-73 247.7 0.0 2.2e-73 247.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ACT03984.1 - 6.9e-10 38.8 0.0 1.2e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ACT03984.1 - 1.7e-09 37.1 0.0 5.9e-09 35.3 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ACT03984.1 - 1.3e-06 27.2 0.0 2.1e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 ACT03984.1 - 0.001 18.4 0.0 0.0018 17.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_MocR PF12897.7 ACT03984.1 - 0.015 14.1 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase Dala_Dala_lig_C PF07478.13 ACT03985.1 - 1.3e-46 158.8 0.0 1.7e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Dala_Dala_lig_N PF01820.21 ACT03985.1 - 8.4e-23 80.8 0.5 1e-21 77.3 0.5 2.4 1 1 0 1 1 1 1 D-ala D-ala ligase N-terminus ATP-grasp_3 PF02655.14 ACT03985.1 - 7e-10 39.2 0.2 2e-09 37.7 0.1 1.8 2 1 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 ACT03985.1 - 2e-07 30.8 0.1 3.8e-07 29.9 0.0 1.4 2 0 0 2 2 2 1 RimK-like ATP-grasp domain GARS_A PF01071.19 ACT03985.1 - 5.4e-07 29.6 0.2 1.2e-06 28.4 0.2 1.7 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp PF02222.22 ACT03985.1 - 1.9e-05 24.3 0.0 3.5e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 ACT03985.1 - 2.9e-05 23.7 0.0 4.4e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 ACT03985.1 - 0.0019 17.8 0.9 0.015 14.9 0.4 2.4 2 1 0 2 2 2 1 ATP-grasp domain Aminotran_1_2 PF00155.21 ACT03986.1 - 3.7e-25 88.9 0.0 4.9e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II GntR PF00392.21 ACT03986.1 - 2.4e-11 43.1 0.0 5e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family Aminotran_MocR PF12897.7 ACT03986.1 - 6.4e-07 28.5 0.0 1.1e-06 27.7 0.0 1.4 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase Rrf2 PF02082.20 ACT03986.1 - 0.018 15.4 0.0 0.052 13.9 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator HTH_36 PF13730.6 ACT03986.1 - 0.057 13.4 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain adh_short_C2 PF13561.6 ACT03987.1 - 3.5e-73 246.0 7.1 4e-73 245.8 7.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT03987.1 - 5.1e-59 199.0 7.7 6e-59 198.8 7.7 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT03987.1 - 8.2e-10 38.9 4.4 1.2e-09 38.3 4.4 1.1 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ACT03987.1 - 0.00042 20.2 1.6 0.00069 19.6 1.6 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF5012 PF16404.5 ACT03987.1 - 0.037 14.1 0.1 0.12 12.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5012) TetR_N PF00440.23 ACT03988.1 - 2.5e-15 56.0 0.2 4e-15 55.3 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_29 PF17938.1 ACT03988.1 - 0.00029 20.9 0.3 0.00051 20.1 0.3 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_24 PF17932.1 ACT03988.1 - 0.00055 20.2 0.1 0.0011 19.3 0.1 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 ACT03988.1 - 0.0022 18.1 0.4 0.0042 17.2 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix of insertion element transposase HTH_7 PF02796.15 ACT03988.1 - 0.071 13.2 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase SLH PF00395.20 ACT03989.1 - 5e-37 125.6 5.8 6.7e-12 45.2 0.1 3.5 3 0 0 3 3 3 3 S-layer homology domain Glyco_hydro_18 PF00704.28 ACT03989.1 - 1.7e-23 83.8 6.2 2.4e-23 83.3 6.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 YjcZ_2 PF09680.10 ACT03990.1 - 0.12 12.0 17.2 0.26 10.9 17.2 1.7 1 1 0 1 1 1 0 Family of unknown function Peptidase_M15_4 PF13539.6 ACT03991.1 - 1.9e-19 69.9 2.5 3.3e-19 69.2 1.5 1.8 2 0 0 2 2 2 1 D-alanyl-D-alanine carboxypeptidase VanY PF02557.17 ACT03991.1 - 7.8e-11 41.9 0.0 1.1e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Peptidase_M15_3 PF08291.11 ACT03991.1 - 0.014 15.5 0.0 5.7 7.1 0.0 2.2 2 0 0 2 2 2 0 Peptidase M15 Polysacc_deac_1 PF01522.21 ACT03992.1 - 4.3e-32 110.6 0.0 6.3e-32 110.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ACT03992.1 - 4.1e-06 26.2 0.1 1.2e-05 24.7 0.1 1.8 1 1 1 2 2 2 1 Glycosyl hydrolase family 57 DUF2334 PF10096.9 ACT03992.1 - 0.035 13.8 0.1 0.046 13.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) MDD_C PF18376.1 ACT03992.1 - 0.084 12.6 0.1 0.2 11.4 0.0 1.6 1 1 0 1 1 1 0 Mevalonate 5-diphosphate decarboxylase C-terminal domain MEKHLA PF08670.11 ACT03993.1 - 4.7e-54 182.2 0.0 5.3e-54 182.0 0.0 1.0 1 0 0 1 1 1 1 MEKHLA domain HAD_2 PF13419.6 ACT03994.1 - 3.3e-13 50.1 0.0 4.7e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ACT03994.1 - 1.1e-08 35.1 0.0 2.8e-08 33.7 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 ACT03994.1 - 3.3e-08 34.1 0.0 1.3e-06 28.8 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Haem_degrading PF03928.14 ACT03995.1 - 1.7e-28 99.1 0.0 1.9e-28 98.9 0.0 1.0 1 0 0 1 1 1 1 Haem-degrading HxlR PF01638.17 ACT03997.1 - 3.5e-28 97.3 0.1 3.9e-28 97.1 0.1 1.0 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.14 ACT03997.1 - 0.00013 21.8 0.1 0.0002 21.2 0.1 1.2 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_24 PF13412.6 ACT03997.1 - 0.0026 17.3 0.0 0.0043 16.6 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 ACT03997.1 - 0.014 15.3 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 MarR family HTH_34 PF13601.6 ACT03997.1 - 0.029 14.5 0.0 0.035 14.3 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain Replic_Relax PF13814.6 ACT03997.1 - 0.21 11.6 0.0 0.27 11.3 0.0 1.1 1 0 0 1 1 1 0 Replication-relaxation adh_short_C2 PF13561.6 ACT03998.1 - 2.6e-41 141.7 1.5 3.1e-41 141.4 1.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT03998.1 - 5.3e-28 97.8 0.3 6.4e-28 97.5 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT03998.1 - 3.9e-07 30.1 1.0 5.6e-07 29.6 1.0 1.2 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 ACT03998.1 - 0.00042 20.8 0.5 0.00087 19.8 0.5 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 ACT03998.1 - 0.007 15.9 0.0 0.022 14.2 0.1 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Pyr_redox_2 PF07992.14 ACT03998.1 - 0.025 13.8 0.1 0.041 13.1 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 ACT03998.1 - 0.036 14.3 0.2 0.061 13.6 0.2 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ADH_zinc_N PF00107.26 ACT03998.1 - 0.079 12.9 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 3HCDH_N PF02737.18 ACT03998.1 - 0.14 12.0 0.3 0.22 11.4 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SQS_PSY PF00494.19 ACT03999.1 - 2.7e-24 86.1 0.1 4.6e-20 72.2 0.0 2.1 2 0 0 2 2 2 2 Squalene/phytoene synthase Ribosomal_S25 PF03297.15 ACT04000.1 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 1 0 1 1 1 0 S25 ribosomal protein ATPgrasp_YheCD PF14398.6 ACT04001.1 - 2.5e-62 210.5 0.0 3.1e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACT04001.1 - 4.6e-09 35.9 0.0 0.00015 21.2 0.0 2.3 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp TTL PF03133.15 ACT04001.1 - 0.0003 20.0 0.0 0.0028 16.8 0.0 2.0 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ACT04002.1 - 1.1e-72 244.3 0.1 1.4e-72 244.0 0.1 1.1 1 0 0 1 1 1 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ACT04002.1 - 6.2e-08 32.2 0.0 0.00032 20.1 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp GSH-S_ATP PF02955.16 ACT04002.1 - 0.00011 21.6 0.3 0.00082 18.8 0.3 2.2 1 1 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain TTL PF03133.15 ACT04002.1 - 0.1 11.7 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 Tubulin-tyrosine ligase family PGA_cap PF09587.10 ACT04003.1 - 9e-68 228.5 0.0 1.2e-67 228.1 0.0 1.1 1 0 0 1 1 1 1 Bacterial capsule synthesis protein PGA_cap Metallophos PF00149.28 ACT04003.1 - 0.0015 19.0 0.0 0.0028 18.2 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase NLPC_P60 PF00877.19 ACT04004.1 - 3.4e-19 68.8 0.1 4.3e-19 68.5 0.1 1.1 1 0 0 1 1 1 1 NlpC/P60 family Amidase_5 PF05382.13 ACT04004.1 - 0.0003 20.7 0.9 0.00058 19.8 0.9 1.5 1 1 0 1 1 1 1 Bacteriophage peptidoglycan hydrolase CHAP PF05257.16 ACT04004.1 - 0.00055 20.5 0.5 0.00077 20.0 0.5 1.4 1 1 0 1 1 1 1 CHAP domain LRAT PF04970.13 ACT04004.1 - 0.0045 17.3 0.2 0.065 13.5 0.1 2.1 2 0 0 2 2 2 1 Lecithin retinol acyltransferase Trp_halogenase PF04820.14 ACT04004.1 - 0.011 14.6 0.0 0.014 14.3 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Abhydrolase_3 PF07859.13 ACT04005.1 - 3e-61 207.0 0.0 4.3e-61 206.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ACT04005.1 - 2.8e-07 29.8 0.0 7.2e-07 28.4 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 ACT04005.1 - 2.5e-05 23.9 0.0 6.7e-05 22.5 0.1 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 ACT04005.1 - 0.0027 16.6 0.0 0.0038 16.2 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase AXE1 PF05448.12 ACT04005.1 - 0.0033 16.2 0.0 0.005 15.6 0.0 1.3 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.16 ACT04005.1 - 0.0097 15.7 0.0 0.056 13.2 0.0 1.9 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase PF00702.26 ACT04006.1 - 0.055 13.7 0.0 0.091 13.0 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase NifU PF01106.17 ACT04006.1 - 0.062 13.5 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 NifU-like domain HMMR_C PF15908.5 ACT04007.1 - 0.022 15.0 0.9 0.038 14.3 0.9 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal TPX2 PF06886.11 ACT04007.1 - 1.8 8.8 6.7 3 8.2 1.4 2.2 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) Phos_pyr_kin PF08543.12 ACT04008.1 - 7.8e-97 323.5 1.2 8.8e-97 323.3 1.2 1.0 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 ACT04008.1 - 5.5e-14 52.2 0.6 7.2e-14 51.8 0.6 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 ACT04008.1 - 9.3e-05 22.0 0.2 0.00017 21.1 0.1 1.7 1 1 0 1 1 1 1 Carbohydrate kinase DAO PF01266.24 ACT04009.1 - 6.6e-61 206.8 1.3 7.4e-61 206.7 1.3 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ACT04009.1 - 3.2e-07 29.9 0.5 0.0046 16.2 0.9 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ACT04009.1 - 6.2e-07 29.6 0.2 2.3e-06 27.7 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ACT04009.1 - 6.5e-07 28.8 0.1 1.1e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ACT04009.1 - 0.00013 20.9 0.9 0.0045 15.7 0.8 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 ACT04009.1 - 0.00061 19.1 1.2 0.004 16.5 1.3 2.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT04009.1 - 0.0015 19.0 1.6 0.0039 17.7 1.6 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ACT04009.1 - 0.0024 17.3 0.0 0.0032 16.9 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ACT04009.1 - 0.01 15.1 1.4 0.016 14.4 1.4 1.3 1 0 0 1 1 1 0 Thi4 family Glyco_transf_4 PF13439.6 ACT04009.1 - 0.02 14.9 0.0 5.5 7.0 0.0 2.3 2 0 0 2 2 2 0 Glycosyltransferase Family 4 UDPG_MGDP_dh_N PF03721.14 ACT04009.1 - 0.067 12.8 0.6 0.12 12.0 0.6 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Amino_oxidase PF01593.24 ACT04009.1 - 0.07 12.4 0.6 0.13 11.5 0.1 1.6 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase ApbA PF02558.16 ACT04009.1 - 0.14 11.8 0.8 0.26 10.9 0.8 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 ACT04009.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ACT04009.1 - 0.16 11.1 1.4 0.27 10.4 1.4 1.3 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 ACT04009.1 - 0.19 11.0 0.4 0.32 10.3 0.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain AdoHcyase_NAD PF00670.21 ACT04009.1 - 0.19 11.8 2.4 0.23 11.5 1.3 1.7 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain TrkA_N PF02254.18 ACT04009.1 - 0.25 11.6 0.8 0.45 10.8 0.8 1.4 1 0 0 1 1 1 0 TrkA-N domain ThiG PF05690.14 ACT04010.1 - 1.7e-106 355.0 0.1 1.9e-106 354.9 0.1 1.0 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 ACT04010.1 - 0.00011 21.7 0.0 0.0019 17.7 0.0 2.1 2 0 0 2 2 2 1 Histidine biosynthesis protein FMN_dh PF01070.18 ACT04010.1 - 0.0068 15.5 0.5 0.02 14.0 0.5 1.6 1 1 0 2 2 2 1 FMN-dependent dehydrogenase IMPDH PF00478.25 ACT04010.1 - 0.023 13.7 0.3 0.033 13.2 0.3 1.2 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain DUF561 PF04481.12 ACT04010.1 - 0.027 13.7 0.1 0.053 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF561) ThiS PF02597.20 ACT04011.1 - 3.5e-10 40.4 0.2 3.9e-10 40.2 0.2 1.0 1 0 0 1 1 1 1 ThiS family TMP-TENI PF02581.17 ACT04012.1 - 5e-66 221.5 1.1 5.7e-66 221.3 1.1 1.0 1 0 0 1 1 1 1 Thiamine monophosphate synthase NMO PF03060.15 ACT04012.1 - 4.9e-05 22.9 1.4 6.5e-05 22.5 1.4 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 ACT04012.1 - 0.00026 20.6 1.6 0.0029 17.1 0.2 2.5 1 1 1 3 3 3 1 Histidine biosynthesis protein IMPDH PF00478.25 ACT04012.1 - 0.017 14.1 5.3 0.35 9.8 4.6 2.0 1 1 1 2 2 2 0 IMP dehydrogenase / GMP reductase domain DUF2957 PF11170.8 ACT04012.1 - 0.026 13.4 0.1 0.029 13.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2957) ThiF PF00899.21 ACT04013.1 - 2.6e-58 197.3 0.0 3.4e-58 196.9 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 ACT04013.1 - 1.1e-05 25.5 0.6 3.5e-05 23.9 0.1 1.9 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 ACT04013.1 - 0.0056 17.1 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding 3HCDH_N PF02737.18 ACT04013.1 - 0.0074 16.2 0.2 0.012 15.5 0.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ACT04013.1 - 0.011 15.9 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 ACT04013.1 - 0.014 15.4 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Sacchrp_dh_NADP PF03435.18 ACT04013.1 - 0.015 15.6 0.3 0.071 13.4 0.3 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 2-Hacid_dh_C PF02826.19 ACT04013.1 - 0.015 14.7 0.2 0.036 13.4 0.1 1.7 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 ACT04013.1 - 0.019 14.2 0.1 0.028 13.7 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 ACT04013.1 - 0.029 14.0 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA KR PF08659.10 ACT04013.1 - 0.041 13.8 0.1 0.069 13.1 0.1 1.4 1 0 0 1 1 1 0 KR domain FAD_binding_3 PF01494.19 ACT04013.1 - 0.044 13.0 0.1 0.063 12.5 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain F420_oxidored PF03807.17 ACT04013.1 - 0.15 12.7 0.0 0.29 11.7 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NMT1 PF09084.11 ACT04014.1 - 1.4e-73 247.4 0.1 1.7e-73 247.1 0.1 1.1 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 ACT04014.1 - 3.1e-05 23.7 0.0 6.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1_2 PF13379.6 ACT04014.1 - 6.3e-05 22.8 0.1 0.00012 21.9 0.1 1.5 1 1 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.20 ACT04014.1 - 0.00016 21.2 0.0 0.00048 19.6 0.0 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 SBP_bac_1 PF01547.25 ACT04014.1 - 0.0017 18.4 0.1 0.0039 17.2 0.1 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT04015.1 - 1.1e-25 90.5 10.3 2.1e-25 89.5 10.3 1.4 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component YbgT_YccB PF08173.11 ACT04015.1 - 0.054 13.6 0.4 0.054 13.6 0.4 2.7 3 0 0 3 3 3 0 Membrane bound YbgT-like protein ABC_tran PF00005.27 ACT04016.1 - 3.2e-25 89.2 0.0 5.2e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04016.1 - 0.00014 21.8 0.0 0.059 13.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ACT04016.1 - 0.013 15.8 0.0 0.037 14.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 ACT04016.1 - 0.04 12.7 0.0 0.11 11.3 0.0 1.6 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_16 PF13191.6 ACT04016.1 - 0.095 13.1 0.3 0.14 12.5 0.3 1.6 1 1 0 1 1 1 0 AAA ATPase domain TENA_THI-4 PF03070.16 ACT04017.1 - 6.9e-53 179.6 0.5 7.7e-53 179.4 0.5 1.0 1 0 0 1 1 1 1 TENA/THI-4/PQQC family DUF3934 PF13070.6 ACT04018.1 - 2.4e-19 69.5 14.9 2.4e-19 69.5 14.9 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF3934) TetR_N PF00440.23 ACT04019.1 - 7.3e-09 35.3 0.1 1.4e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_Tnp_1_2 PF13022.6 ACT04019.1 - 0.0048 17.0 0.1 0.014 15.5 0.0 1.9 1 1 1 2 2 2 1 Helix-turn-helix of insertion element transposase TetR_C_11 PF16859.5 ACT04019.1 - 0.038 14.3 0.0 0.1 12.9 0.0 1.7 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Phage_int_SAM_5 PF13102.6 ACT04019.1 - 0.066 13.6 0.6 33 4.9 0.0 3.2 2 1 1 3 3 3 0 Phage integrase SAM-like domain HTH_23 PF13384.6 ACT04019.1 - 0.075 12.9 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain LacI PF00356.21 ACT04019.1 - 0.085 12.7 0.1 0.29 11.0 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family HTH_10 PF04967.12 ACT04019.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain HTH_22 PF13309.6 ACT04019.1 - 0.12 12.5 0.1 0.8 9.8 0.1 2.3 2 0 0 2 2 2 0 HTH domain Terminase_5 PF06056.12 ACT04019.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) ABC_tran PF00005.27 ACT04020.1 - 2e-26 93.1 0.0 3.8e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04020.1 - 4.2e-17 62.9 0.5 1.5e-13 51.2 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 ACT04020.1 - 0.00012 22.8 0.1 0.00031 21.4 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_23 PF13476.6 ACT04020.1 - 0.013 16.0 0.5 0.026 15.0 0.5 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ACT04020.1 - 0.025 14.3 0.1 0.046 13.5 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 ACT04020.1 - 0.034 13.9 0.1 7.6 6.1 0.0 2.2 1 1 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 ACT04020.1 - 0.048 13.6 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 ACT04020.1 - 0.058 13.1 0.1 0.25 11.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ACT04020.1 - 0.063 13.6 0.5 1.2 9.4 0.5 2.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ACT04020.1 - 0.072 13.5 0.0 0.12 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.22 ACT04020.1 - 0.11 12.1 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain SMC_N PF02463.19 ACT04020.1 - 0.12 11.7 0.3 6 6.2 0.1 2.5 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain ABC2_membrane_2 PF12679.7 ACT04021.1 - 5.8e-15 55.3 15.0 7.1e-15 55.0 15.0 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_5 PF13346.6 ACT04021.1 - 0.0034 17.0 12.2 0.0034 17.0 12.2 2.0 2 1 0 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 ACT04021.1 - 0.023 14.7 7.5 0.051 13.5 7.5 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein UPF0182 PF03699.13 ACT04021.1 - 0.087 10.9 2.5 0.12 10.5 2.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) PEP-CTERM PF07589.11 ACT04021.1 - 3.3 7.9 8.8 0.64 10.2 0.5 3.3 2 0 0 2 2 2 0 PEP-CTERM motif Glyco_hydro_130 PF04041.13 ACT04022.1 - 8.5e-57 192.5 0.0 4.6e-55 186.8 0.0 2.0 1 1 1 2 2 2 2 beta-1,4-mannooligosaccharide phosphorylase Glyco_hydro_43 PF04616.14 ACT04022.1 - 0.002 17.5 0.1 0.013 14.8 0.1 2.1 1 1 1 2 2 2 1 Glycosyl hydrolases family 43 DUF1861 PF08950.10 ACT04023.1 - 4.2e-131 436.6 0.0 5.2e-131 436.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1861) Kelch_6 PF13964.6 ACT04023.1 - 0.0035 17.6 0.0 0.021 15.1 0.0 2.1 2 0 0 2 2 2 1 Kelch motif BPD_transp_1 PF00528.22 ACT04024.1 - 4.3e-13 49.4 19.0 4.3e-13 49.4 19.0 2.0 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component PIN_11 PF18479.1 ACT04024.1 - 0.11 12.7 0.9 0.21 11.8 0.3 1.8 2 0 0 2 2 2 0 PIN like domain BPD_transp_1 PF00528.22 ACT04025.1 - 6.9e-18 65.0 10.5 6.9e-18 65.0 10.5 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF4713 PF15831.5 ACT04025.1 - 4.7 7.7 5.7 1.5 9.4 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4713) SBP_bac_8 PF13416.6 ACT04026.1 - 2.7e-50 171.7 12.7 4.3e-50 171.1 12.7 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Peripla_BP_3 PF13377.6 ACT04027.1 - 1.8e-37 129.2 0.0 3.5e-37 128.3 0.0 1.5 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT04027.1 - 1.6e-15 57.3 0.0 2.1e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT04027.1 - 3.4e-06 26.7 0.0 6e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACT04027.1 - 1.9e-05 24.4 0.0 2.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_10 PF04967.12 ACT04027.1 - 0.026 14.3 0.1 0.14 11.9 0.0 2.2 2 0 0 2 2 2 0 HTH DNA binding domain HTH_19 PF12844.7 ACT04027.1 - 0.097 12.7 0.2 1.5 8.9 0.0 2.6 2 1 1 3 3 3 0 Helix-turn-helix domain HTH_31 PF13560.6 ACT04027.1 - 0.16 12.4 0.0 6.7 7.1 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain MarR_2 PF12802.7 ACT04027.1 - 0.16 11.9 0.0 0.44 10.5 0.0 1.8 1 0 0 1 1 1 0 MarR family AAA_33 PF13671.6 ACT04029.1 - 2.5e-10 40.7 0.0 3.3e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ACT04029.1 - 2.9e-06 27.9 0.0 9.1e-06 26.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 ACT04029.1 - 0.00012 22.3 0.0 0.0002 21.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase AAA_28 PF13521.6 ACT04029.1 - 0.0002 21.6 0.0 0.00038 20.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 ACT04029.1 - 0.00069 19.4 0.0 0.00097 18.9 0.0 1.3 1 1 0 1 1 1 1 Cytidylate kinase AAA_17 PF13207.6 ACT04029.1 - 0.0025 18.2 0.1 0.0041 17.5 0.1 1.4 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ACT04029.1 - 0.0026 17.1 0.0 0.0048 16.2 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA PF00004.29 ACT04029.1 - 0.0028 18.1 0.1 0.0046 17.4 0.1 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ACT04029.1 - 0.0043 17.6 0.0 0.0046 17.5 0.0 1.4 1 1 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 ACT04029.1 - 0.0086 15.8 0.1 0.0092 15.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 ACT04029.1 - 0.0088 16.3 0.0 0.011 16.0 0.0 1.2 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain TsaE PF02367.17 ACT04029.1 - 0.015 15.3 0.6 0.034 14.2 0.2 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CbiA PF01656.23 ACT04029.1 - 0.017 15.2 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain PduV-EutP PF10662.9 ACT04029.1 - 0.02 14.6 0.1 0.043 13.6 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 ACT04029.1 - 0.025 14.8 0.0 0.042 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ACT04029.1 - 0.028 14.3 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 ACT04029.1 - 0.038 13.9 0.0 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ACT04029.1 - 0.043 14.2 0.2 0.075 13.4 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 ACT04029.1 - 0.044 13.2 0.1 0.08 12.4 0.1 1.5 2 0 0 2 2 2 0 PhoH-like protein dNK PF01712.19 ACT04029.1 - 0.046 13.6 0.0 0.59 10.0 0.0 2.0 2 0 0 2 2 2 0 Deoxynucleoside kinase NB-ARC PF00931.22 ACT04029.1 - 0.06 12.5 0.1 0.091 11.9 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain IPT PF01745.16 ACT04029.1 - 0.068 12.6 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Isopentenyl transferase SRP54 PF00448.22 ACT04029.1 - 0.079 12.6 0.3 0.12 12.0 0.3 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain CoaE PF01121.20 ACT04029.1 - 0.081 12.6 0.1 0.081 12.6 0.1 1.5 2 0 0 2 2 1 0 Dephospho-CoA kinase Sigma54_activ_2 PF14532.6 ACT04029.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 ACT04029.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ACT04029.1 - 0.17 11.7 0.2 0.3 10.8 0.0 1.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein APS_kinase PF01583.20 ACT04029.1 - 0.18 11.7 0.1 0.41 10.5 0.1 1.5 1 1 0 1 1 1 0 Adenylylsulphate kinase RNA_helicase PF00910.22 ACT04029.1 - 0.21 12.0 0.0 0.46 10.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase CYTH PF01928.21 ACT04030.1 - 9.3e-08 32.2 3.7 1.3e-07 31.7 3.7 1.2 1 0 0 1 1 1 1 CYTH domain CsrA PF02599.16 ACT04030.1 - 0.22 11.5 1.4 7.7 6.6 0.0 3.0 2 1 1 3 3 3 0 Global regulator protein family AdoMet_dc PF02675.15 ACT04031.1 - 4.3e-31 107.3 0.0 7.6e-31 106.5 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine decarboxylase DUF779 PF05610.11 ACT04033.1 - 1.2e-47 160.1 0.0 1.4e-47 159.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF779) Aldedh PF00171.22 ACT04034.1 - 6.9e-163 542.4 0.0 7.9e-163 542.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family OmdA PF13376.6 ACT04034.1 - 0.0093 16.0 0.2 0.023 14.7 0.2 1.6 1 0 0 1 1 1 1 Bacteriocin-protection, YdeI or OmpD-Associated DUF1487 PF07368.11 ACT04034.1 - 0.21 11.0 0.0 1.1 8.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) HSP90 PF00183.18 ACT04035.1 - 2.9e-114 382.8 22.6 6.3e-109 365.2 14.1 2.5 2 1 1 3 3 3 2 Hsp90 protein HATPase_c_3 PF13589.6 ACT04035.1 - 1.2e-12 47.8 0.3 2.6e-12 46.7 0.3 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ACT04035.1 - 2.5e-10 40.9 0.1 6.4e-10 39.5 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Beta-lactamase PF00144.24 ACT04036.1 - 7.5e-37 127.3 0.0 1.1e-36 126.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Catalase PF00199.19 ACT04037.1 - 2.7e-199 662.0 0.3 3.3e-199 661.8 0.3 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ACT04037.1 - 2.2e-26 91.8 0.0 4.6e-26 90.8 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Gp_dh_C PF02800.20 ACT04038.1 - 4.2e-39 133.7 0.0 6.9e-39 133.0 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ACT04038.1 - 8.6e-21 74.2 0.0 1.7e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 ACT04038.1 - 0.081 12.9 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Glyoxalase PF00903.25 ACT04039.1 - 3e-28 98.6 0.2 4e-28 98.2 0.2 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ACT04039.1 - 0.0064 16.8 0.0 3.1 8.1 0.0 2.6 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Ferritin PF00210.24 ACT04040.1 - 8.3e-33 113.3 1.0 9.2e-33 113.2 1.0 1.0 1 0 0 1 1 1 1 Ferritin-like domain Glyoxalase_6 PF18029.1 ACT04040.1 - 0.054 14.3 0.0 0.083 13.7 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase-like domain COX1 PF00115.20 ACT04041.1 - 6e-09 35.3 7.2 8.1e-09 34.8 7.2 1.4 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DUF4212 PF13937.6 ACT04041.1 - 1.4 9.3 6.4 0.62 10.5 1.9 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4212) MFS_1 PF07690.16 ACT04042.1 - 1.2e-46 159.3 47.2 2.3e-30 105.7 30.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT04042.1 - 7e-09 35.0 36.3 6.1e-08 32.0 15.7 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 ACT04042.1 - 9.3e-07 28.0 22.5 0.00051 19.0 16.9 2.4 1 1 1 2 2 2 2 MFS_1 like family MFS_3 PF05977.13 ACT04042.1 - 0.002 16.6 12.6 0.014 13.8 3.9 2.2 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_4 PF06779.14 ACT04042.1 - 0.13 11.5 22.6 0.21 10.8 22.6 1.3 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB Amidohydro_3 PF07969.11 ACT04043.1 - 4.3e-113 379.3 0.0 1.9e-112 377.1 0.0 1.8 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_1 PF01979.20 ACT04043.1 - 8.1e-09 35.2 0.0 7e-07 28.9 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family DUF1427 PF07235.11 ACT04044.1 - 3.3e-14 52.6 2.6 3.9e-14 52.4 2.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1427) Isochorismatase PF00857.20 ACT04045.1 - 3.5e-26 92.4 0.2 7e-26 91.5 0.2 1.5 1 1 0 1 1 1 1 Isochorismatase family Myb_DNA-binding PF00249.31 ACT04045.1 - 0.075 13.2 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain Abhydrolase_1 PF00561.20 ACT04046.1 - 3.5e-31 108.8 0.1 1.1e-30 107.1 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ACT04046.1 - 5.4e-21 76.2 1.5 6.5e-21 76.0 1.5 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACT04046.1 - 1.1e-19 70.6 0.0 1e-13 51.1 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 ACT04046.1 - 0.00022 21.3 0.0 0.00038 20.5 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein DUF915 PF06028.11 ACT04046.1 - 0.00045 19.6 0.0 0.0033 16.8 0.0 2.2 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.7 ACT04046.1 - 0.00095 19.0 0.0 0.41 10.4 0.0 2.4 2 0 0 2 2 2 2 Alpha/beta hydrolase family Lipase_2 PF01674.18 ACT04046.1 - 0.011 15.2 0.2 0.031 13.8 0.0 1.8 2 1 0 2 2 2 0 Lipase (class 2) Peptidase_S9 PF00326.21 ACT04046.1 - 0.012 15.1 0.3 1.2 8.5 0.0 2.4 2 1 0 2 2 2 0 Prolyl oligopeptidase family FSH1 PF03959.13 ACT04046.1 - 0.016 14.9 0.0 0.062 12.9 0.0 2.1 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 ACT04046.1 - 0.036 13.9 0.0 4.7 7.0 0.0 2.8 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase EHN PF06441.12 ACT04046.1 - 0.048 14.0 0.2 1.5 9.3 0.1 2.6 3 0 0 3 3 3 0 Epoxide hydrolase N terminus UPF0227 PF05728.12 ACT04046.1 - 0.049 13.6 0.0 0.44 10.5 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) PGAP1 PF07819.13 ACT04046.1 - 0.25 11.0 0.4 4.4 7.0 0.2 2.2 1 1 1 2 2 2 0 PGAP1-like protein Response_reg PF00072.24 ACT04047.1 - 5.3e-26 91.0 0.1 1.6e-25 89.4 0.1 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT04047.1 - 3.4e-19 68.9 0.1 1.1e-18 67.2 0.1 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04047.1 - 5.6e-14 51.8 0.7 5.4e-06 26.4 0.5 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT04047.1 - 0.00033 20.9 0.1 0.00092 19.5 0.1 1.8 1 0 0 1 1 1 1 GGDEF-like domain RNA_pol_Rpb1_7 PF04990.12 ACT04047.1 - 0.038 14.0 0.2 0.18 11.8 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 7 Phage_int_SAM_5 PF13102.6 ACT04047.1 - 0.15 12.4 0.8 0.34 11.3 0.8 1.5 1 0 0 1 1 1 0 Phage integrase SAM-like domain His_kinase PF06580.13 ACT04048.1 - 1.4e-20 73.3 0.4 1.4e-20 73.3 0.4 3.1 3 1 0 3 3 3 1 Histidine kinase HATPase_c PF02518.26 ACT04048.1 - 8.7e-11 42.3 0.0 3.3e-10 40.5 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT04048.1 - 1.5e-08 34.9 0.0 3.6e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 HAMP domain dCache_1 PF02743.18 ACT04048.1 - 0.00033 20.5 2.8 0.00033 20.5 2.8 2.2 3 0 0 3 3 3 1 Cache domain HATPase_c_5 PF14501.6 ACT04048.1 - 0.042 13.8 1.2 0.12 12.3 0.1 2.4 2 0 0 2 2 2 0 GHKL domain SBP_bac_8 PF13416.6 ACT04049.1 - 6.1e-35 121.4 5.6 6.1e-35 121.4 5.6 1.8 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein LysR_substrate PF03466.20 ACT04050.1 - 4.8e-28 98.0 0.0 6.1e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT04050.1 - 6.6e-20 70.8 0.0 1.2e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 ACT04050.1 - 0.098 11.8 0.0 1.2 8.2 0.0 2.2 2 0 0 2 2 2 0 PBP superfamily domain LysR_substrate PF03466.20 ACT04051.1 - 2e-33 115.6 0.0 2.5e-33 115.2 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT04051.1 - 1.9e-19 69.4 0.0 3.3e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family UvsY PF11056.8 ACT04051.1 - 0.017 15.4 0.2 0.15 12.4 0.1 2.3 2 1 0 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY HTH_5 PF01022.20 ACT04051.1 - 0.026 14.4 0.1 0.12 12.2 0.0 2.2 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family MatE PF01554.18 ACT04052.1 - 4.8e-43 146.6 30.6 1.6e-30 105.9 11.9 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 ACT04052.1 - 5e-08 33.1 5.8 5e-08 33.1 5.8 4.3 2 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain HTH_18 PF12833.7 ACT04053.1 - 3e-20 72.3 0.5 4.9e-20 71.6 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04053.1 - 4.7e-19 68.0 0.1 2.5e-09 37.0 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT04053.1 - 7.3e-14 51.8 0.0 1.6e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT04053.1 - 1.9e-11 43.5 0.0 3.2e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Ectoine_synth PF06339.12 ACT04053.1 - 0.00012 22.2 0.0 0.0002 21.5 0.0 1.3 1 0 0 1 1 1 1 Ectoine synthase Cupin_3 PF05899.12 ACT04053.1 - 0.00017 21.2 0.0 0.00041 20.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF861) HTH_Crp_2 PF13545.6 ACT04053.1 - 0.0098 15.8 0.0 2.2 8.3 0.0 2.4 1 1 1 2 2 2 2 Crp-like helix-turn-helix domain Cupin_2 PF07883.11 ACT04054.1 - 6.9e-18 64.1 0.0 9.4e-18 63.7 0.0 1.1 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ACT04054.1 - 8.9e-07 28.9 0.0 1e-06 28.7 0.0 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain EutQ PF06249.12 ACT04054.1 - 1.3e-06 28.3 0.0 1.5e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ MannoseP_isomer PF01050.18 ACT04054.1 - 6.7e-05 22.8 0.0 8e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_3 PF05899.12 ACT04054.1 - 7.6e-05 22.3 0.0 0.00011 21.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_1 PF00190.22 ACT04054.1 - 0.00014 21.5 0.0 0.00023 20.8 0.0 1.3 1 1 0 1 1 1 1 Cupin Cupin_6 PF12852.7 ACT04054.1 - 0.00047 19.9 0.0 0.00049 19.9 0.0 1.2 1 0 0 1 1 1 1 Cupin ARD PF03079.14 ACT04054.1 - 0.02 15.1 0.0 0.031 14.5 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family CENP-C_C PF11699.8 ACT04054.1 - 0.044 14.0 0.0 0.056 13.7 0.0 1.1 1 0 0 1 1 1 0 Mif2/CENP-C like DMSP_lyase PF16867.5 ACT04054.1 - 0.05 13.2 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase Asp_Arg_Hydrox PF05118.15 ACT04054.1 - 0.064 13.1 0.0 0.078 12.8 0.0 1.1 1 0 0 1 1 1 0 Aspartyl/Asparaginyl beta-hydroxylase Glycos_transf_2 PF00535.26 ACT04055.1 - 2.1e-11 43.9 0.6 3.5e-11 43.2 0.6 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACT04055.1 - 3.8e-08 33.5 0.0 7e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ACT04055.1 - 0.068 13.1 0.1 0.59 10.0 0.1 2.3 2 1 0 2 2 2 0 Glycosyl transferase family group 2 Glycos_transf_1 PF00534.20 ACT04056.1 - 1.1e-23 83.6 0.0 1.8e-23 82.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT04056.1 - 4.8e-17 62.6 0.0 1e-16 61.6 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACT04056.1 - 3.3e-06 27.2 0.1 5.8e-05 23.2 0.1 2.4 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACT04056.1 - 0.062 13.7 0.1 0.27 11.7 0.0 2.0 2 1 1 3 3 3 0 Glycosyl transferase 4-like domain NTP_transferase PF00483.23 ACT04057.1 - 1e-42 146.5 0.0 1.2e-42 146.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ACT04057.1 - 2.7e-09 37.6 0.0 4.5e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 ACT04057.1 - 7.9e-05 22.2 4.8 0.0067 16.1 0.1 3.2 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 ACT04057.1 - 0.00031 19.8 0.0 0.00042 19.4 0.0 1.1 1 0 0 1 1 1 1 L-fucokinase DUF4954 PF16314.5 ACT04057.1 - 0.059 11.5 0.0 0.093 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) UDPG_MGDP_dh_N PF03721.14 ACT04058.1 - 3.3e-65 219.2 0.0 1.5e-64 217.0 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 ACT04058.1 - 3.3e-37 126.6 0.0 6e-37 125.7 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 ACT04058.1 - 5.8e-33 113.5 0.0 1e-31 109.5 0.0 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain F420_oxidored PF03807.17 ACT04058.1 - 5.1e-08 33.4 0.1 0.0081 16.7 0.0 3.6 3 1 0 3 3 3 2 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 ACT04058.1 - 2.7e-05 23.9 0.1 6.5e-05 22.6 0.1 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 ACT04058.1 - 5.5e-05 23.4 0.0 0.011 15.9 0.0 2.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 ACT04058.1 - 0.00013 21.9 0.0 0.00027 20.9 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ACT04058.1 - 0.00028 21.3 0.0 0.27 11.7 0.0 2.8 2 1 0 2 2 2 2 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 ACT04058.1 - 0.00055 19.3 0.2 0.0024 17.2 0.2 1.9 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_Gly3P_dh_N PF01210.23 ACT04058.1 - 0.0019 18.2 0.0 0.1 12.6 0.0 2.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 ACT04058.1 - 0.0083 15.5 0.2 0.14 11.5 0.1 2.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ACT04058.1 - 0.022 15.3 0.3 0.057 14.0 0.3 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ACT04058.1 - 0.025 13.8 0.0 0.052 12.8 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 ACT04058.1 - 0.04 14.2 0.1 0.16 12.3 0.1 2.0 2 0 0 2 2 2 0 TrkA-N domain DpaA_N PF16924.5 ACT04058.1 - 0.065 13.3 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain Toprim PF01751.22 ACT04058.1 - 0.12 12.6 0.0 17 5.7 0.0 2.5 2 0 0 2 2 2 0 Toprim domain DAO PF01266.24 ACT04058.1 - 0.62 9.6 2.2 1.5 8.3 1.5 1.8 2 1 0 2 2 2 0 FAD dependent oxidoreductase DUF2961 PF11175.8 ACT04059.1 - 7.3e-93 310.5 6.4 8.9e-93 310.3 6.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2961) Glyco_hydro2_C5 PF18565.1 ACT04060.1 - 1.8e-32 111.2 0.3 6.5e-31 106.2 0.0 2.4 2 0 0 2 2 2 1 Glycoside hydrolase family 2 C-terminal domain 5 Glyco_hydro_2_C PF02836.17 ACT04060.1 - 1.3e-28 100.0 0.2 1.9e-27 96.2 0.2 2.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 ACT04060.1 - 5e-27 94.9 1.8 1e-26 93.8 1.8 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 ACT04060.1 - 4.6e-23 82.0 0.3 1.3e-22 80.5 0.3 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 DUF4982 PF16355.5 ACT04060.1 - 5.2e-18 64.8 0.0 1.5e-17 63.3 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4982) Invasin_D3 PF09134.10 ACT04060.1 - 5.6e-05 23.4 1.4 0.00056 20.2 0.0 2.8 2 1 1 3 3 3 1 Invasin, domain 3 HTH_AraC PF00165.23 ACT04061.1 - 1.1e-20 73.1 0.0 1.5e-10 40.8 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT04061.1 - 1.8e-20 73.0 0.0 3.9e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT04061.1 - 4.6e-13 49.2 0.6 9e-13 48.3 0.6 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain AraC_binding_2 PF14525.6 ACT04061.1 - 0.0012 18.5 0.0 0.0018 17.9 0.0 1.5 1 1 0 1 1 1 1 AraC-binding-like domain Cupin_2 PF07883.11 ACT04061.1 - 0.0057 16.3 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 Cupin domain Glyoxalase PF00903.25 ACT04062.1 - 6.9e-06 26.3 0.2 0.00024 21.3 0.3 2.6 2 1 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DUF4105 PF13387.6 ACT04062.1 - 0.026 14.2 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) Glyoxalase_4 PF13669.6 ACT04062.1 - 0.073 13.4 0.0 1.4 9.2 0.0 2.4 1 1 2 3 3 3 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Melibiase PF02065.18 ACT04064.1 - 3.6e-169 562.2 0.0 4.5e-169 561.9 0.0 1.1 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 ACT04064.1 - 8.1e-96 320.4 0.0 1.2e-95 319.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 N-terminal domain Glyco_hydro_36C PF16874.5 ACT04064.1 - 1.3e-26 92.9 0.0 4.5e-26 91.1 0.0 2.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 C-terminal domain GHL10 PF02638.15 ACT04064.1 - 1.6e-05 24.2 0.0 2.6e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase-like 10 Glyco_hydro_31 PF01055.26 ACT04064.1 - 0.00018 20.8 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Melibiase_2 PF16499.5 ACT04064.1 - 0.15 11.2 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 Alpha galactosidase A Peptidase_C54 PF03416.19 ACT04064.1 - 0.17 11.3 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Peptidase family C54 Peripla_BP_3 PF13377.6 ACT04065.1 - 1.4e-44 152.3 0.0 1.5e-43 149.0 0.0 2.1 2 0 0 2 2 2 1 Periplasmic binding protein-like domain LacI PF00356.21 ACT04065.1 - 9.7e-18 63.7 0.1 1.9e-17 62.8 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_1 PF00532.21 ACT04065.1 - 3.8e-15 56.1 0.0 6.4e-15 55.3 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT04065.1 - 5.9e-06 26.1 0.0 3.6e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 Periplasmic binding protein domain HTH_7 PF02796.15 ACT04065.1 - 0.00047 20.2 0.0 0.013 15.5 0.0 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 ACT04065.1 - 0.0052 16.5 0.1 0.028 14.2 0.0 2.3 3 0 0 3 3 2 1 Helix-turn-helix domain MarR_2 PF12802.7 ACT04065.1 - 0.0078 16.1 0.3 0.072 13.0 0.0 2.6 3 0 0 3 3 3 1 MarR family HTH_23 PF13384.6 ACT04065.1 - 0.0084 15.9 0.0 0.04 13.7 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_3 PF01381.22 ACT04065.1 - 0.01 15.9 0.0 0.024 14.7 0.0 1.6 1 1 0 1 1 1 0 Helix-turn-helix MarR PF01047.22 ACT04065.1 - 0.024 14.5 0.0 0.2 11.6 0.0 2.5 3 0 0 3 3 3 0 MarR family HTH_Tnp_ISL3 PF13542.6 ACT04065.1 - 0.026 14.0 0.5 0.06 12.8 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_AraC PF00165.23 ACT04065.1 - 0.027 14.6 0.0 0.15 12.2 0.0 2.1 1 1 1 2 2 2 0 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_Crp_2 PF13545.6 ACT04065.1 - 0.047 13.7 1.8 0.11 12.5 0.0 2.5 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain HTH_19 PF12844.7 ACT04065.1 - 0.066 13.2 0.0 2.4 8.3 0.0 2.3 1 1 1 2 2 2 0 Helix-turn-helix domain Fe_dep_repress PF01325.19 ACT04065.1 - 0.079 13.2 0.1 0.84 9.9 0.2 2.5 3 0 0 3 3 3 0 Iron dependent repressor, N-terminal DNA binding domain TetR_N PF00440.23 ACT04065.1 - 0.083 12.7 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family Trp_repressor PF01371.19 ACT04065.1 - 0.14 12.3 0.8 0.59 10.3 0.1 2.3 2 0 0 2 2 2 0 Trp repressor protein HTH_29 PF13551.6 ACT04065.1 - 0.14 12.2 0.0 0.5 10.4 0.0 2.0 1 0 0 1 1 1 0 Winged helix-turn helix HTH_24 PF13412.6 ACT04065.1 - 0.23 11.0 1.0 0.39 10.3 0.1 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding ABC_tran PF00005.27 ACT04066.1 - 7.6e-33 113.9 0.0 1.1e-32 113.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT04066.1 - 3.9e-06 26.4 0.1 7e-05 22.4 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT04066.1 - 0.00021 21.2 0.0 0.4 10.5 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT04066.1 - 0.00047 19.8 0.3 0.0012 18.5 0.2 1.7 1 1 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT04066.1 - 0.0014 19.1 0.2 0.002 18.6 0.2 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 ACT04066.1 - 0.0069 16.1 0.3 0.0099 15.6 0.3 1.5 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 ACT04066.1 - 0.014 14.5 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 ACT04066.1 - 0.021 14.4 0.0 0.043 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ACT04066.1 - 0.025 14.5 0.1 0.044 13.7 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ACT04066.1 - 0.044 14.0 0.9 0.24 11.7 0.3 2.4 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ACT04066.1 - 0.051 13.7 0.4 0.078 13.1 0.4 1.7 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 ACT04066.1 - 0.065 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 ACT04066.1 - 0.095 12.4 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain FtsX PF02687.21 ACT04067.1 - 4.3e-05 23.9 6.9 4.3e-05 23.9 6.9 3.2 2 1 1 3 3 3 1 FtsX-like permease family Orf78 PF06024.12 ACT04067.1 - 0.12 12.7 0.1 0.12 12.7 0.1 2.1 2 0 0 2 2 2 0 Orf78 (ac78) DUF4271 PF14093.6 ACT04067.1 - 0.14 12.1 9.1 0.047 13.6 3.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) Sigma_reg_N PF13800.6 ACT04067.1 - 1.8 8.9 4.2 8.5 6.7 0.1 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DHHC PF01529.20 ACT04067.1 - 9.4 6.3 8.2 10 6.2 4.0 2.3 2 0 0 2 2 2 0 DHHC palmitoyltransferase HATPase_c PF02518.26 ACT04068.1 - 8.2e-28 97.2 0.0 1.5e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT04068.1 - 6.5e-15 55.2 0.1 1.3e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 HAMP domain HisKA PF00512.25 ACT04068.1 - 8.1e-15 54.6 0.5 2e-14 53.4 0.5 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 ACT04068.1 - 0.0016 18.3 0.0 0.0033 17.3 0.0 1.5 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 ACT04068.1 - 0.027 14.3 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT04068.1 - 0.06 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Sigma_reg_N PF13800.6 ACT04068.1 - 0.12 12.6 3.2 0.31 11.4 0.1 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal SpoU_methylase PF00588.19 ACT04068.1 - 0.17 12.0 0.1 0.67 10.1 0.0 1.9 2 0 0 2 2 2 0 SpoU rRNA Methylase family FtsX PF02687.21 ACT04068.1 - 0.28 11.7 2.5 1.2 9.6 0.1 2.3 2 0 0 2 2 2 0 FtsX-like permease family Response_reg PF00072.24 ACT04069.1 - 4.3e-29 100.9 0.0 6.2e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT04069.1 - 5e-24 84.2 0.0 9.6e-24 83.3 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Fer4 PF00037.27 ACT04070.1 - 5.3e-09 35.5 11.0 2.5e-07 30.2 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 ACT04070.1 - 1.1e-07 31.9 7.9 1.7e-07 31.3 7.9 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 ACT04070.1 - 1.2e-07 31.5 11.9 8e-06 25.7 1.7 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 ACT04070.1 - 1.8e-07 31.6 10.2 2.1e-05 25.0 12.3 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 ACT04070.1 - 1.9e-07 31.9 6.2 0.00056 20.8 1.3 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 ACT04070.1 - 2.2e-05 24.5 11.1 0.00024 21.2 12.3 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 ACT04070.1 - 3.3e-05 23.7 2.7 3.3e-05 23.7 2.7 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_21 PF14697.6 ACT04070.1 - 0.0001 22.4 14.1 0.0009 19.3 14.1 2.1 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 ACT04070.1 - 0.0037 17.8 12.2 0.045 14.3 2.1 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_15 PF13459.6 ACT04070.1 - 0.01 16.5 11.0 0.77 10.5 11.0 2.4 1 1 0 1 1 1 0 4Fe-4S single cluster domain Fer4_18 PF13746.6 ACT04070.1 - 0.021 15.0 3.7 0.021 15.0 3.7 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 ACT04070.1 - 0.034 14.7 13.0 0.62 10.6 13.0 2.2 1 1 0 1 1 1 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_4 PF12800.7 ACT04070.1 - 0.037 14.5 13.3 0.12 13.0 4.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_8 PF13183.6 ACT04070.1 - 0.054 13.9 14.0 1.9 9.0 2.7 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 ACT04070.1 - 0.064 14.2 4.6 0.064 14.2 4.6 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain DUF3079 PF11278.8 ACT04070.1 - 0.2 11.5 0.2 0.2 11.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3079) FAD_binding_2 PF00890.24 ACT04071.1 - 2.5e-23 82.9 4.1 8.9e-22 77.7 1.1 2.9 2 1 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 ACT04071.1 - 3e-11 43.1 0.2 5.6e-08 32.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ACT04071.1 - 1.1e-10 41.4 0.2 1.7e-10 40.9 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 ACT04071.1 - 2.8e-09 37.0 12.1 9.2e-09 35.3 3.8 3.0 2 2 0 2 2 2 1 FAD dependent oxidoreductase Succ_DH_flav_C PF02910.20 ACT04071.1 - 1.5e-07 31.4 0.1 2.7e-07 30.6 0.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 ACT04071.1 - 2.3e-07 30.3 0.2 3e-05 23.3 0.3 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 ACT04071.1 - 8.3e-07 28.1 1.3 8.3e-07 28.1 1.3 3.0 2 1 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 ACT04071.1 - 0.0015 17.9 0.6 0.0036 16.6 0.6 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 ACT04071.1 - 0.0028 17.0 1.6 0.015 14.6 0.3 2.5 3 0 0 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.6 ACT04071.1 - 0.0046 17.2 0.5 0.016 15.4 0.5 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ACT04071.1 - 0.0075 15.6 0.4 0.36 10.0 0.5 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ACT04071.1 - 0.0096 15.2 0.2 0.13 11.5 0.3 2.2 2 0 0 2 2 2 1 Thi4 family DLH PF01738.18 ACT04072.1 - 3.2e-09 36.6 0.0 2.8e-08 33.6 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family Esterase PF00756.20 ACT04072.1 - 2.8e-05 23.9 0.0 4e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.7 ACT04072.1 - 4e-05 22.6 0.0 6.4e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 ACT04072.1 - 0.00047 19.5 0.1 0.015 14.6 0.0 2.1 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 ACT04072.1 - 0.0069 15.4 0.0 0.01 14.9 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase Esterase_phd PF10503.9 ACT04072.1 - 0.015 14.8 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase Abhydrolase_1 PF00561.20 ACT04072.1 - 0.025 14.2 0.0 4 7.0 0.0 2.2 1 1 1 2 2 2 0 alpha/beta hydrolase fold Glycos_trans_3N PF02885.17 ACT04072.1 - 0.15 11.9 0.5 42 4.1 0.0 3.5 3 1 1 4 4 4 0 Glycosyl transferase family, helical bundle domain NMT1 PF09084.11 ACT04073.1 - 3.9e-11 43.3 0.0 6.4e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 ACT04073.1 - 3.8e-06 26.7 0.0 5.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 ACT04073.1 - 1.4e-05 24.6 0.0 7e-05 22.3 0.0 2.2 1 1 1 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 NMT1_2 PF13379.6 ACT04073.1 - 4.8e-05 23.2 0.0 0.00021 21.0 0.0 2.1 2 1 0 2 2 2 1 NMT1-like family OpuAC PF04069.12 ACT04073.1 - 0.0011 18.6 0.1 0.047 13.3 0.1 2.7 1 1 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system MukB_hinge PF16330.5 ACT04073.1 - 0.064 13.0 0.0 0.15 11.8 0.0 1.6 1 1 0 1 1 1 0 MukB hinge domain Tic110 PF16940.5 ACT04073.1 - 0.1 11.0 0.4 0.14 10.6 0.4 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter Fer4 PF00037.27 ACT04074.1 - 3.4e-10 39.3 9.9 1.8e-07 30.7 1.9 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 ACT04074.1 - 8.5e-09 36.2 3.6 0.00015 22.6 1.0 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 ACT04074.1 - 7e-08 32.5 9.4 1e-07 32.0 9.4 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 ACT04074.1 - 1.5e-07 31.1 12.1 7e-06 25.9 2.3 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 ACT04074.1 - 2.4e-07 31.2 12.4 7.8e-07 29.6 12.6 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 ACT04074.1 - 1.1e-06 28.6 14.4 3.1e-05 24.0 14.4 2.2 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ACT04074.1 - 2.1e-06 27.7 10.5 1.1e-05 25.5 11.3 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 ACT04074.1 - 4.5e-05 23.6 13.4 0.0021 18.4 4.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 ACT04074.1 - 5.8e-05 23.6 8.7 0.0071 16.9 1.9 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 ACT04074.1 - 0.00051 20.0 4.0 0.00051 20.0 4.0 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_15 PF13459.6 ACT04074.1 - 0.00084 20.0 1.1 0.00084 20.0 1.1 2.7 1 1 1 2 2 2 1 4Fe-4S single cluster domain Fer4_3 PF12798.7 ACT04074.1 - 0.0036 18.1 18.3 0.079 13.9 6.9 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_22 PF17179.4 ACT04074.1 - 0.0044 17.8 4.8 0.099 13.5 1.1 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 ACT04074.1 - 0.0059 17.0 15.1 0.27 11.7 4.7 2.3 2 1 1 3 3 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 ACT04074.1 - 0.0094 16.5 12.6 0.088 13.4 11.9 2.2 1 1 1 2 2 2 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 ACT04074.1 - 0.03 14.5 12.9 0.39 10.9 11.1 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain DUF3079 PF11278.8 ACT04074.1 - 5.2 7.0 7.9 0.34 10.7 0.3 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3079) FAD_binding_2 PF00890.24 ACT04075.1 - 3.7e-25 88.9 9.2 2.2e-21 76.4 2.7 3.3 3 1 0 3 3 3 2 FAD binding domain Pyr_redox_2 PF07992.14 ACT04075.1 - 2.5e-15 56.5 0.1 3.2e-09 36.5 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT04075.1 - 2e-11 44.1 5.4 4.1e-09 36.5 5.4 2.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ACT04075.1 - 2.2e-11 43.8 0.3 4.1e-11 42.9 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Succ_DH_flav_C PF02910.20 ACT04075.1 - 5.9e-11 42.5 0.6 1.1e-10 41.6 0.6 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term HI0933_like PF03486.14 ACT04075.1 - 6.1e-10 38.4 7.6 2.6e-09 36.3 0.4 2.9 2 1 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 ACT04075.1 - 5.4e-05 22.6 0.3 0.13 11.5 1.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ACT04075.1 - 7.2e-05 22.0 9.2 0.00012 21.3 2.3 2.6 3 0 0 3 3 3 2 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ACT04075.1 - 0.00011 21.6 0.6 0.0055 16.0 0.3 2.3 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 ACT04075.1 - 0.00024 20.5 0.7 0.00024 20.5 0.7 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 ACT04075.1 - 0.041 13.1 0.8 0.74 9.0 0.4 2.3 2 0 0 2 2 2 0 Thi4 family NAD_binding_8 PF13450.6 ACT04075.1 - 0.044 14.0 0.4 0.17 12.1 0.4 2.1 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 ACT04075.1 - 0.16 12.4 0.1 0.44 11.0 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding BPD_transp_1 PF00528.22 ACT04076.1 - 1.3e-27 96.7 11.9 1.3e-27 96.7 11.9 1.7 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Romo1 PF10247.9 ACT04076.1 - 0.0088 16.4 0.3 0.029 14.7 0.3 1.9 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 SecE PF00584.20 ACT04076.1 - 0.054 13.4 0.4 0.16 11.9 0.4 1.8 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex Gly-zipper_YMGG PF13441.6 ACT04076.1 - 0.99 9.2 11.4 0.52 10.1 1.5 3.4 3 2 0 3 3 3 0 YMGG-like Gly-zipper BPD_transp_1 PF00528.22 ACT04077.1 - 3.3e-30 105.2 13.5 3.3e-30 105.2 13.5 1.4 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component RRM_8 PF11835.8 ACT04077.1 - 0.017 15.3 0.0 0.025 14.8 0.0 1.3 1 0 0 1 1 1 0 RRM-like domain ATP-synt_C PF00137.21 ACT04077.1 - 5 7.5 11.9 1.4 9.3 2.1 3.0 3 0 0 3 3 3 0 ATP synthase subunit C MFS_1 PF07690.16 ACT04078.1 - 5.9e-53 180.0 46.9 5.9e-53 180.0 46.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily YajC PF02699.15 ACT04078.1 - 0.23 11.4 1.4 0.88 9.5 0.1 2.7 2 0 0 2 2 2 0 Preprotein translocase subunit MFS_3 PF05977.13 ACT04078.1 - 0.32 9.4 18.0 0.0075 14.7 10.7 1.9 2 0 0 2 2 2 0 Transmembrane secretion effector MFS_2 PF13347.6 ACT04078.1 - 0.44 9.0 41.1 0.5 8.9 22.1 2.9 2 2 0 2 2 2 0 MFS/sugar transport protein DUF1751 PF08551.10 ACT04078.1 - 7.2 7.2 11.6 0.12 13.0 0.8 3.6 3 1 1 4 4 4 0 Eukaryotic integral membrane protein (DUF1751) TetR_N PF00440.23 ACT04079.1 - 6.6e-11 41.8 0.1 1.4e-09 37.6 0.0 2.7 3 0 0 3 3 3 1 Bacterial regulatory proteins, tetR family HTH_7 PF02796.15 ACT04079.1 - 0.001 19.1 0.0 0.0025 17.8 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_Tnp_1_2 PF13022.6 ACT04079.1 - 0.048 13.8 0.0 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase HTH_23 PF13384.6 ACT04079.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain SdpI PF13630.6 ACT04080.1 - 3.5e-20 71.9 3.3 3.5e-20 71.9 3.3 3.3 3 1 0 3 3 3 1 SdpI/YhfL protein family DUF1648 PF07853.11 ACT04080.1 - 5.1e-07 29.3 0.1 5.1e-07 29.3 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1648) DUF5510 PF17629.2 ACT04080.1 - 0.068 13.1 1.7 5.5 7.0 0.2 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5510) COX6C PF02937.15 ACT04080.1 - 0.083 13.0 0.1 15 5.8 0.2 2.5 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc DUF3040 PF11239.8 ACT04080.1 - 1.5 9.1 12.9 2.2 8.6 1.5 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3040) Lig_chan PF00060.26 ACT04080.1 - 4.9 7.0 5.8 1.7e+02 2.0 5.8 2.7 1 1 0 1 1 1 0 Ligand-gated ion channel HTH_20 PF12840.7 ACT04081.1 - 1e-17 63.9 0.0 1.2e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 ACT04081.1 - 9.1e-17 60.7 0.1 1.2e-16 60.3 0.1 1.2 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 ACT04081.1 - 1.4e-09 37.7 0.0 1.7e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 ACT04081.1 - 2.4e-06 27.4 0.1 3.1e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 ACT04081.1 - 2.9e-06 26.7 0.0 3.8e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Sigma70_r4_2 PF08281.12 ACT04081.1 - 7e-05 22.4 0.0 9.9e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 Rrf2 PF02082.20 ACT04081.1 - 0.00011 22.5 0.1 0.00023 21.5 0.1 1.5 1 1 1 2 2 2 1 Transcriptional regulator HTH_Crp_2 PF13545.6 ACT04081.1 - 0.00034 20.5 0.1 0.00052 19.9 0.1 1.4 1 1 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_23 PF13384.6 ACT04081.1 - 0.00037 20.2 0.0 0.00047 19.9 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4 PF04545.16 ACT04081.1 - 0.00053 19.4 0.0 0.00083 18.8 0.0 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 UPF0122 PF04297.14 ACT04081.1 - 0.00054 20.1 0.0 0.00057 20.1 0.0 1.2 1 0 0 1 1 1 1 Putative helix-turn-helix protein, YlxM / p13 like HTH_IclR PF09339.10 ACT04081.1 - 0.00055 19.7 0.1 0.0008 19.2 0.1 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain DUF4423 PF14394.6 ACT04081.1 - 0.00067 19.4 0.0 0.00098 18.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) HTH_38 PF13936.6 ACT04081.1 - 0.00081 19.1 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.6 ACT04081.1 - 0.00082 19.4 0.0 0.0011 19.0 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 ACT04081.1 - 0.0018 18.2 0.2 0.0025 17.8 0.2 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 ACT04081.1 - 0.0029 17.4 0.0 0.0042 16.9 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB GerE PF00196.19 ACT04081.1 - 0.0033 16.9 0.0 0.0046 16.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family GntR PF00392.21 ACT04081.1 - 0.0051 16.4 0.0 0.015 14.9 0.0 1.9 1 1 1 2 2 2 1 Bacterial regulatory proteins, gntR family MarR PF01047.22 ACT04081.1 - 0.012 15.5 0.1 0.016 15.1 0.1 1.2 1 0 0 1 1 1 0 MarR family HTH_32 PF13565.6 ACT04081.1 - 0.012 16.2 0.0 0.021 15.4 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_41 PF14502.6 ACT04081.1 - 0.014 15.1 0.0 0.069 12.9 0.0 2.0 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_DeoR PF08220.12 ACT04081.1 - 0.015 15.1 0.2 0.021 14.6 0.2 1.2 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_10 PF04967.12 ACT04081.1 - 0.016 15.0 0.0 0.031 14.1 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain HTH_40 PF14493.6 ACT04081.1 - 0.027 14.9 0.1 0.03 14.8 0.1 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_7 PF02796.15 ACT04081.1 - 0.036 14.2 0.0 0.068 13.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase DUF1492 PF07374.11 ACT04081.1 - 0.054 13.7 0.0 0.082 13.1 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1492) HTH_22 PF13309.6 ACT04081.1 - 0.068 13.3 0.0 0.23 11.6 0.0 1.9 1 1 0 1 1 1 0 HTH domain Fe_dep_repress PF01325.19 ACT04081.1 - 0.069 13.4 0.0 0.097 12.9 0.0 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain PuR_N PF09182.10 ACT04081.1 - 0.081 12.9 0.0 0.12 12.3 0.0 1.4 1 1 0 1 1 1 0 Bacterial purine repressor, N-terminal HTH_36 PF13730.6 ACT04081.1 - 0.081 12.9 0.0 0.26 11.3 0.0 1.7 1 1 1 2 2 2 0 Helix-turn-helix domain Phage_rep_O PF04492.13 ACT04081.1 - 0.085 13.5 0.1 0.11 13.1 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage replication protein O ArsR PF09824.9 ACT04081.1 - 0.12 12.0 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 ArsR transcriptional regulator NUMOD1 PF07453.13 ACT04081.1 - 0.12 12.6 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 NUMOD1 domain Pro-kuma_activ PF09286.11 ACT04081.1 - 0.13 12.5 0.0 0.15 12.4 0.0 1.1 1 0 0 1 1 1 0 Pro-kumamolisin, activation domain TetR_N PF00440.23 ACT04082.1 - 4.3e-15 55.2 0.0 7.6e-15 54.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_1 PF02909.17 ACT04082.1 - 2.7e-14 53.2 0.1 4.6e-14 52.5 0.1 1.3 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain MatE PF01554.18 ACT04083.1 - 6.7e-41 139.6 47.2 4.8e-21 75.1 15.2 3.0 2 1 1 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ACT04083.1 - 1.1e-05 25.6 31.5 2.2e-05 24.6 14.7 4.9 3 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain YbgT_YccB PF08173.11 ACT04083.1 - 0.24 11.5 3.0 12 6.1 0.1 3.7 3 0 0 3 3 3 0 Membrane bound YbgT-like protein DUF4337 PF14235.6 ACT04083.1 - 1 9.4 3.2 3.9 7.6 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) ABC2_membrane PF01061.24 ACT04084.1 - 3.1e-23 82.3 21.4 3.1e-23 82.3 21.4 1.3 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ACT04084.1 - 1.3e-13 50.8 20.0 1.3e-13 50.8 20.0 1.9 1 1 1 2 2 2 1 ABC-2 family transporter protein DUF3767 PF12597.8 ACT04084.1 - 0.17 11.7 0.2 4.5 7.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3767) ABC_tran PF00005.27 ACT04085.1 - 9.3e-30 103.9 0.1 1.8e-29 103.0 0.0 1.5 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ACT04085.1 - 8.2e-14 52.1 0.4 1.4e-08 34.9 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ACT04085.1 - 1.5e-05 24.9 0.0 0.025 14.3 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 ACT04085.1 - 0.00015 22.3 0.2 0.00019 22.0 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ACT04085.1 - 0.00066 19.4 0.2 0.0013 18.4 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain KdpD PF02702.17 ACT04085.1 - 0.0013 18.3 0.0 0.0032 17.0 0.0 1.5 1 1 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain AAA_16 PF13191.6 ACT04085.1 - 0.0039 17.6 0.2 0.0055 17.1 0.2 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT04085.1 - 0.011 16.0 0.0 0.028 14.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ACT04085.1 - 0.016 14.9 0.1 0.035 13.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 ACT04085.1 - 0.023 13.7 0.1 0.035 13.1 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 ACT04085.1 - 0.039 14.4 0.1 0.42 11.0 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 ACT04085.1 - 0.04 13.4 0.1 0.38 10.2 0.1 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_5 PF07728.14 ACT04085.1 - 0.041 13.9 0.3 0.14 12.1 0.1 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 ACT04085.1 - 0.046 13.6 0.0 0.075 13.0 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 ACT04085.1 - 0.058 13.1 2.1 0.071 12.8 0.7 1.8 2 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ACT04085.1 - 0.066 13.1 0.2 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 RsgA GTPase CbiA PF01656.23 ACT04085.1 - 0.089 12.8 0.0 0.11 12.6 0.0 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain TsaE PF02367.17 ACT04085.1 - 0.14 12.2 0.2 0.29 11.2 0.2 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TNT PF14021.6 ACT04085.1 - 0.14 12.7 0.0 0.34 11.5 0.0 1.6 1 0 0 1 1 1 0 Tuberculosis necrotizing toxin Mg_chelatase PF01078.21 ACT04085.1 - 0.16 11.4 0.0 0.36 10.2 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PRK PF00485.18 ACT04085.1 - 0.16 11.7 0.1 0.31 10.8 0.1 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Pentapeptide_4 PF13599.6 ACT04086.1 - 2.7e-39 133.2 25.6 2.2e-13 50.2 0.9 3.8 1 1 4 5 5 5 5 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 ACT04086.1 - 1e-27 95.3 21.1 7.8e-09 35.0 2.0 6.7 3 2 2 7 7 7 5 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 ACT04086.1 - 2.2e-21 75.7 24.9 1.1e-07 31.9 3.8 6.3 3 1 3 6 6 6 6 Pentapeptide repeats (9 copies) CfAFP PF05264.11 ACT04086.1 - 0.022 14.8 0.1 1.7 8.7 0.1 2.3 1 1 1 2 2 2 0 Choristoneura fumiferana antifreeze protein (CfAFP) PadR PF03551.14 ACT04087.1 - 6.2e-21 74.1 0.7 7.7e-21 73.8 0.7 1.1 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.6 ACT04087.1 - 0.11 12.7 0.0 0.16 12.2 0.0 1.4 1 1 0 1 1 1 0 Winged helix DNA-binding domain GalKase_gal_bdg PF10509.9 ACT04088.1 - 1.5e-16 59.7 0.1 4.1e-16 58.3 0.1 1.8 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 ACT04088.1 - 2.2e-08 34.2 0.8 5.4e-08 33.0 0.4 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain Glyoxalase PF00903.25 ACT04089.1 - 1.2e-09 38.4 0.0 2.9e-09 37.2 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ACT04089.1 - 9.9e-08 31.9 0.0 1.2e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 ACT04089.1 - 3.1e-07 31.1 0.1 4e-07 30.8 0.1 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 ACT04089.1 - 0.13 12.6 0.1 0.67 10.3 0.1 2.0 1 1 1 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily SBP_bac_8 PF13416.6 ACT04090.1 - 1.9e-19 70.6 5.7 3.7e-19 69.6 5.7 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT04090.1 - 9.6e-17 61.9 3.2 1.5e-16 61.2 3.2 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein vWA-TerF-like PF10138.9 ACT04090.1 - 0.041 14.0 0.0 0.073 13.2 0.0 1.4 1 0 0 1 1 1 0 vWA found in TerF C terminus DinB_2 PF12867.7 ACT04092.1 - 4.1e-13 50.0 0.2 4.6e-13 49.8 0.2 1.0 1 0 0 1 1 1 1 DinB superfamily Fucose_iso_C PF02952.17 ACT04092.1 - 0.0099 15.6 0.7 0.44 10.2 0.3 2.1 2 0 0 2 2 2 2 L-fucose isomerase, C-terminal domain PMSR PF01625.21 ACT04093.1 - 5.5e-56 189.0 1.1 9.5e-56 188.2 1.1 1.4 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase SelR PF01641.18 ACT04093.1 - 1.3e-35 122.1 0.0 2.4e-35 121.2 0.0 1.4 1 0 0 1 1 1 1 SelR domain Response_reg PF00072.24 ACT04094.1 - 7.5e-30 103.4 0.2 1.2e-29 102.7 0.2 1.4 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 ACT04094.1 - 1.4e-19 69.3 0.1 2.2e-19 68.8 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACT04094.1 - 2.4e-06 27.1 0.0 4.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT04094.1 - 1.5e-05 24.4 0.0 3.2e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_40 PF14493.6 ACT04094.1 - 0.0079 16.6 0.0 0.024 15.1 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 ACT04094.1 - 0.012 15.2 0.0 0.024 14.2 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HisKA_3 PF07730.13 ACT04095.1 - 2.3e-15 56.8 2.8 2.3e-15 56.8 2.8 1.9 2 0 0 2 2 2 1 Histidine kinase HATPase_c PF02518.26 ACT04095.1 - 0.0014 19.2 0.0 0.033 14.7 0.0 2.4 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1980 PF09323.10 ACT04095.1 - 0.052 13.5 0.2 0.052 13.5 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) F5_F8_type_C PF00754.25 ACT04096.1 - 2.3e-88 292.8 52.9 1.2e-24 86.9 2.1 6.5 6 1 1 7 7 7 4 F5/8 type C domain Glyco_hydro81C PF17652.1 ACT04096.1 - 3e-42 145.1 10.8 5.8e-42 144.2 10.8 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Muskelin_N PF06588.11 ACT04096.1 - 0.01 15.8 0.5 0.044 13.7 0.0 2.4 3 0 0 3 3 3 0 Muskelin N-terminus Prophage_tail PF06605.11 ACT04096.1 - 0.021 14.0 1.8 0.031 13.5 0.4 1.9 2 0 0 2 2 2 0 Prophage endopeptidase tail UnbV_ASPIC PF07593.12 ACT04096.1 - 4.3 7.4 6.8 8.6 6.4 0.0 4.2 6 0 0 6 6 6 0 ASPIC and UnbV LAB_N PF07578.11 ACT04097.1 - 1e-30 105.6 3.8 1e-30 105.6 3.8 1.9 2 0 0 2 2 2 1 Lipid A Biosynthesis N-terminal domain Glycos_transf_2 PF00535.26 ACT04098.1 - 2e-26 92.8 0.1 2.7e-26 92.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACT04098.1 - 6.1e-11 42.6 0.0 1.2e-10 41.7 0.0 1.4 1 1 1 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ACT04098.1 - 5.5e-06 26.0 0.1 3.1e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 GDP_Man_Dehyd PF16363.5 ACT04099.1 - 2.2e-60 204.8 0.2 3.5e-58 197.6 0.2 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ACT04099.1 - 4.5e-54 183.5 0.1 6.6e-54 182.9 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ACT04099.1 - 8.3e-21 74.2 0.4 7.6e-20 71.1 0.4 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ACT04099.1 - 1.6e-11 43.9 0.0 1.3e-10 40.8 0.0 1.9 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ACT04099.1 - 8.4e-11 41.5 0.1 4.4e-09 35.9 0.1 2.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ACT04099.1 - 1.4e-10 40.8 0.1 4.3e-09 35.9 0.1 2.7 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 ACT04099.1 - 6.1e-10 39.3 0.0 1.2e-05 25.3 0.0 2.2 2 0 0 2 2 2 2 NAD(P)H-binding KR PF08659.10 ACT04099.1 - 7.4e-06 26.0 0.4 0.00024 21.1 0.5 3.0 2 1 0 2 2 2 1 KR domain adh_short PF00106.25 ACT04099.1 - 0.00019 20.9 0.3 0.04 13.4 0.0 3.1 2 1 1 3 3 3 1 short chain dehydrogenase DUF327 PF03885.13 ACT04099.1 - 0.17 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF327) UDPG_MGDP_dh_N PF03721.14 ACT04100.1 - 1.4e-58 197.6 0.1 1.9e-58 197.1 0.1 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 ACT04100.1 - 1e-34 118.6 0.0 2.3e-34 117.5 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 ACT04100.1 - 6e-29 100.5 0.0 9.6e-28 96.7 0.0 2.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_2 PF03446.15 ACT04100.1 - 5.7e-05 23.3 0.1 0.012 15.8 0.2 2.8 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACT04100.1 - 0.00023 21.7 0.2 2.2 8.9 0.1 3.7 3 1 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 ACT04100.1 - 0.00058 19.8 0.0 0.0015 18.5 0.0 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 ACT04100.1 - 0.0047 16.6 0.1 0.0097 15.6 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 ACT04100.1 - 0.023 14.0 0.3 0.33 10.3 0.0 2.8 4 0 0 4 4 4 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 ACT04100.1 - 0.027 14.5 0.0 0.096 12.7 0.0 1.9 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.19 ACT04100.1 - 0.042 13.1 0.1 0.067 12.4 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 ACT04100.1 - 0.054 14.1 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF4406 PF14359.6 ACT04100.1 - 0.11 12.9 0.1 0.59 10.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4406) MarR PF01047.22 ACT04101.1 - 6.2e-13 48.5 0.2 2e-12 46.8 0.2 1.9 1 1 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT04101.1 - 7.6e-12 44.9 0.0 1.2e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT04101.1 - 3.2e-09 37.1 0.0 6.2e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.6 ACT04101.1 - 3.8e-07 29.6 0.1 9.1e-07 28.4 0.1 1.7 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding HxlR PF01638.17 ACT04101.1 - 3e-06 27.0 0.0 4.7e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 HxlR-like helix-turn-helix Fe_dep_repress PF01325.19 ACT04101.1 - 4.8e-06 26.7 0.1 1.6e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain TrmB PF01978.19 ACT04101.1 - 0.00047 20.0 0.0 0.001 18.9 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.20 ACT04101.1 - 0.0013 18.6 0.3 0.0035 17.2 0.0 1.8 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_IclR PF09339.10 ACT04101.1 - 0.0019 17.9 0.1 0.0066 16.2 0.0 1.9 2 0 0 2 2 2 1 IclR helix-turn-helix domain GntR PF00392.21 ACT04101.1 - 0.0047 16.6 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_34 PF13601.6 ACT04101.1 - 0.01 16.0 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain DUF4364 PF14277.6 ACT04101.1 - 0.011 15.5 0.1 0.013 15.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) Rrf2 PF02082.20 ACT04101.1 - 0.015 15.6 0.0 0.03 14.7 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator HTH_Crp_2 PF13545.6 ACT04101.1 - 0.016 15.2 0.1 0.035 14.1 0.0 1.7 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain SMC_ScpB PF04079.16 ACT04101.1 - 0.021 14.4 0.0 0.063 12.9 0.0 1.7 1 1 0 1 1 1 0 Segregation and condensation complex subunit ScpB HTH_6 PF01418.17 ACT04101.1 - 0.034 14.1 0.0 0.095 12.7 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family PCI PF01399.27 ACT04101.1 - 0.04 14.4 0.2 0.29 11.7 0.0 2.0 2 1 0 2 2 2 0 PCI domain TFIIE_alpha PF02002.17 ACT04101.1 - 0.04 13.8 0.8 0.19 11.6 0.2 2.3 2 1 0 2 2 2 0 TFIIE alpha subunit RQC PF09382.10 ACT04101.1 - 0.094 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 RQC domain RPA_C PF08784.11 ACT04101.1 - 0.095 13.4 0.0 0.16 12.7 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal NTP_transf_6 PF06042.11 ACT04102.1 - 5.6e-57 192.0 0.0 7.9e-57 191.6 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyltransferase His_Phos_1 PF00300.22 ACT04102.1 - 6.3e-26 91.3 0.1 9.3e-26 90.7 0.1 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) cNMP_binding PF00027.29 ACT04103.1 - 3.5e-09 36.6 0.0 5.6e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 ACT04103.1 - 0.0001 22.2 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Crp PF00325.20 ACT04103.1 - 0.0002 20.9 0.1 0.00036 20.1 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, crp family Sigma70_r4 PF04545.16 ACT04103.1 - 0.074 12.6 0.1 0.16 11.5 0.1 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 NAD_binding_1 PF00175.21 ACT04104.1 - 1.1e-16 61.4 0.0 8.9e-16 58.5 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Globin PF00042.22 ACT04104.1 - 2.1e-11 44.4 0.0 6.9e-11 42.7 0.0 1.9 2 0 0 2 2 2 1 Globin FAD_binding_6 PF00970.24 ACT04104.1 - 5.6e-07 29.8 0.0 1.1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ACT04104.1 - 0.00025 21.2 0.0 0.0026 17.9 0.0 2.5 3 0 0 3 3 3 1 Ferric reductase NAD binding domain Protoglobin PF11563.8 ACT04104.1 - 0.002 18.0 0.3 0.004 17.1 0.3 1.5 1 1 0 1 1 1 1 Protoglobin PYNP_C PF07831.13 ACT04104.1 - 0.085 12.5 0.1 7.1 6.4 0.1 2.5 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain NitrOD1 PF18549.1 ACT04104.1 - 0.088 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Nitrosopumilus output domain 1 PAE PF03283.13 ACT04105.1 - 0.14 11.3 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Pectinacetylesterase AAA_5 PF07728.14 ACT04106.1 - 1.4e-12 47.8 0.0 3.6e-12 46.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ACT04106.1 - 7.6e-08 32.9 0.0 1.3e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ACT04106.1 - 2.7e-06 27.9 0.0 0.0026 18.2 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_3 PF07726.11 ACT04106.1 - 6.3e-05 22.8 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 ACT04106.1 - 0.017 14.3 0.0 0.032 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.12 ACT04106.1 - 0.022 14.7 0.0 0.11 12.4 0.0 2.2 3 0 0 3 3 3 0 NACHT domain AAA_28 PF13521.6 ACT04106.1 - 0.023 14.9 0.0 0.047 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 ACT04106.1 - 0.035 13.9 0.0 0.8 9.4 0.0 2.2 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ACT04106.1 - 0.037 14.4 0.0 0.15 12.4 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.6 ACT04106.1 - 0.044 13.8 0.0 0.12 12.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 ACT04106.1 - 0.074 13.5 0.1 0.24 11.8 0.0 1.9 3 0 0 3 3 2 0 AAA domain Sigma54_activat PF00158.26 ACT04106.1 - 0.075 12.7 0.0 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain IPT PF01745.16 ACT04106.1 - 0.077 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase AAA_24 PF13479.6 ACT04106.1 - 0.092 12.5 0.0 0.28 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 ACT04106.1 - 0.1 12.0 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein DUF2201_N PF13203.6 ACT04107.1 - 1.3e-21 77.5 3.7 1.1e-14 54.7 1.4 3.2 2 1 0 2 2 2 2 Putative metallopeptidase domain DUF2201 PF09967.9 ACT04107.1 - 3.7e-05 23.9 0.0 6.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 VWA-like domain (DUF2201) Peptidase_M48 PF01435.18 ACT04107.1 - 0.0029 17.4 1.3 0.026 14.3 0.2 2.1 2 0 0 2 2 2 1 Peptidase family M48 Peptidase_M78 PF06114.13 ACT04107.1 - 0.005 16.8 0.6 0.072 13.0 0.1 2.3 2 0 0 2 2 2 1 IrrE N-terminal-like domain Acetyltransf_1 PF00583.25 ACT04109.1 - 5.7e-15 55.6 0.0 7e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT04109.1 - 1.1e-09 38.6 0.0 1.6e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT04109.1 - 5.7e-08 32.7 0.0 7.8e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ACT04109.1 - 1.6e-07 31.5 0.0 1.8e-07 31.3 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT04109.1 - 1e-06 28.6 0.1 2.3e-06 27.5 0.0 1.6 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 ACT04109.1 - 3.4e-05 24.5 0.0 4.4e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ACT04109.1 - 0.007 16.1 0.0 0.028 14.1 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3040 PF11239.8 ACT04109.1 - 0.031 14.5 0.1 0.049 13.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Acetyltransf_4 PF13420.7 ACT04109.1 - 0.064 13.4 0.0 0.08 13.1 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain UPF0146 PF03686.13 ACT04109.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0146) OmdA PF13376.6 ACT04110.1 - 6.5e-20 70.9 1.8 2.1e-19 69.3 0.6 2.2 2 0 0 2 2 2 1 Bacteriocin-protection, YdeI or OmpD-Associated DUF1054 PF06335.12 ACT04110.1 - 0.014 15.3 0.1 0.025 14.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1054) Nudix_hydro PF18290.1 ACT04110.1 - 0.12 12.4 1.3 2.3 8.3 0.0 3.1 3 1 1 4 4 4 0 Nudix hydrolase domain NIF3 PF01784.18 ACT04111.1 - 3.9e-25 88.9 0.0 5.1e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Usp PF00582.26 ACT04112.1 - 8.1e-34 117.1 0.3 9.1e-34 117.0 0.3 1.0 1 0 0 1 1 1 1 Universal stress protein family Peripla_BP_6 PF13458.6 ACT04112.1 - 0.057 13.1 0.0 0.074 12.7 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein Cass2 PF14526.6 ACT04113.1 - 1.1e-12 48.3 0.1 1.4e-12 48.0 0.1 1.1 1 0 0 1 1 1 1 Integron-associated effector binding protein GyrI-like PF06445.15 ACT04113.1 - 6.1e-11 42.9 0.1 8.2e-11 42.4 0.1 1.3 1 1 0 1 1 1 1 GyrI-like small molecule binding domain DUF3502 PF12010.8 ACT04114.1 - 1.6e-28 99.9 2.6 1.6e-28 99.9 2.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) YTV PF07639.11 ACT04114.1 - 0.076 13.1 0.8 0.15 12.2 0.8 1.4 1 0 0 1 1 1 0 YTV BPD_transp_1 PF00528.22 ACT04115.1 - 2.2e-06 27.5 25.0 9.6e-05 22.2 24.9 2.3 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04116.1 - 7.6e-12 45.3 16.6 7.6e-12 45.3 16.6 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component TM_helix PF05552.12 ACT04116.1 - 0.032 14.2 3.0 0.32 11.0 3.0 2.7 1 1 0 1 1 1 0 Conserved TM helix Glyco_hydro_35 PF01301.19 ACT04117.1 - 7.8e-60 203.1 0.0 1.8e-59 202.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 ACT04117.1 - 4e-06 26.4 0.1 7.7e-06 25.5 0.1 1.5 1 1 0 1 1 1 1 Beta-galactosidase Glyco_hydro_2_N PF02837.18 ACT04117.1 - 0.0008 19.4 0.0 0.29 11.0 0.0 2.7 2 0 0 2 2 2 2 Glycosyl hydrolases family 2, sugar binding domain Peripla_BP_3 PF13377.6 ACT04118.1 - 9.7e-39 133.3 0.0 2.5e-38 132.0 0.0 1.6 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT04118.1 - 6e-30 104.6 0.0 8e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 ACT04118.1 - 7.9e-17 61.7 0.0 1.5e-16 60.8 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding protein domain LacI PF00356.21 ACT04118.1 - 5.8e-16 58.0 1.1 5.8e-16 58.0 1.1 2.2 2 0 0 2 2 2 1 Bacterial regulatory proteins, lacI family IF2_N PF04760.15 ACT04118.1 - 0.0053 16.5 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region HTH_7 PF02796.15 ACT04118.1 - 0.0096 16.0 0.1 0.027 14.5 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase TrmB PF01978.19 ACT04118.1 - 0.028 14.3 0.3 0.12 12.3 0.1 2.2 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_15 PF12324.8 ACT04118.1 - 0.032 14.2 0.3 0.067 13.2 0.3 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase Sigma54_DBD PF04552.13 ACT04118.1 - 0.033 13.9 0.1 0.068 12.9 0.1 1.6 1 0 0 1 1 1 0 Sigma-54, DNA binding domain Trp_repressor PF01371.19 ACT04118.1 - 0.043 14.0 0.0 0.18 12.0 0.0 2.1 2 0 0 2 2 2 0 Trp repressor protein MarR PF01047.22 ACT04118.1 - 0.068 13.1 0.1 0.2 11.6 0.0 1.8 2 0 0 2 2 1 0 MarR family HTH_11 PF08279.12 ACT04118.1 - 0.087 12.8 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 HTH domain TetR_N PF00440.23 ACT04118.1 - 0.097 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_38 PF13936.6 ACT04118.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_3 PF01381.22 ACT04118.1 - 0.12 12.4 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix MarR_2 PF12802.7 ACT04118.1 - 0.15 12.0 0.0 0.41 10.6 0.0 1.8 2 0 0 2 2 1 0 MarR family HTH_Tnp_ISL3 PF13542.6 ACT04118.1 - 0.15 11.5 0.1 2.7 7.5 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 ACT04118.1 - 0.16 11.8 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Crp_2 PF13545.6 ACT04118.1 - 0.18 11.8 0.0 0.71 9.9 0.0 2.0 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain NAD_synthase PF02540.17 ACT04119.1 - 1.7e-67 227.1 0.0 2e-67 226.8 0.0 1.1 1 0 0 1 1 1 1 NAD synthase ATP_bind_3 PF01171.20 ACT04119.1 - 0.15 11.8 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 PP-loop family CTP_transf_like PF01467.26 ACT04120.1 - 1.5e-24 86.8 0.1 1.7e-24 86.6 0.1 1.0 1 0 0 1 1 1 1 Cytidylyltransferase-like NAPRTase_N PF17767.1 ACT04121.1 - 6.8e-40 136.3 0.7 2.9e-39 134.3 0.2 2.1 2 1 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase_C PF17956.1 ACT04121.1 - 2.3e-27 95.6 0.1 5.7e-27 94.3 0.1 1.7 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 ACT04121.1 - 5.6e-09 36.0 0.0 9.2e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family QRPTase_C PF01729.19 ACT04121.1 - 0.00049 19.9 0.0 0.00079 19.2 0.0 1.3 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain Isochorismatase PF00857.20 ACT04122.1 - 0.018 15.2 0.0 0.5 10.5 0.0 2.3 2 1 0 2 2 2 0 Isochorismatase family NUDIX PF00293.28 ACT04123.1 - 1.8e-14 53.9 0.3 3.1e-14 53.2 0.3 1.3 1 0 0 1 1 1 1 NUDIX domain Spore_permease PF03845.13 ACT04124.1 - 9.9e-50 169.2 39.8 1.5e-49 168.6 39.8 1.3 1 0 0 1 1 1 1 Spore germination protein Smim3 PF17307.2 ACT04124.1 - 0.033 13.7 0.8 0.16 11.5 0.0 2.6 2 0 0 2 2 2 0 Small integral membrane protein 3 DUF4834 PF16118.5 ACT04124.1 - 2.1 9.4 0.0 2.1 9.4 0.0 4.1 5 1 0 5 5 5 0 Domain of unknown function (DUF4834) Spore_GerAC PF05504.11 ACT04126.1 - 2.3e-41 141.8 0.6 2.3e-41 141.8 0.6 1.5 2 0 0 2 2 2 1 Spore germination B3/ GerAC like, C-terminal SecB PF02556.14 ACT04126.1 - 0.14 12.1 0.1 14 5.5 0.0 2.4 2 0 0 2 2 2 0 Preprotein translocase subunit SecB GerA PF03323.13 ACT04127.1 - 3.6e-185 615.9 1.1 4.1e-185 615.7 1.1 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein TaqI_C PF12950.7 ACT04128.1 - 0.14 12.2 0.8 0.62 10.1 0.3 2.0 1 1 1 2 2 2 0 TaqI-like C-terminal specificity domain DUF1600 PF07667.11 ACT04129.1 - 0.014 15.5 6.0 0.016 15.4 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1600) DUF2207 PF09972.9 ACT04129.1 - 1.8 7.3 4.5 1.7 7.3 4.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PspB PF06667.12 ACT04129.1 - 9.9 6.3 7.2 1.2 9.2 3.3 1.5 2 0 0 2 2 2 0 Phage shock protein B Conotoxin PF02950.17 ACT04130.1 - 0.17 12.9 0.0 0.26 12.3 0.0 1.3 1 0 0 1 1 1 0 Conotoxin LPAM_2 PF13627.6 ACT04130.1 - 0.87 9.5 4.1 1.3 9.0 4.1 1.3 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Glyoxalase PF00903.25 ACT04131.1 - 0.00051 20.2 0.0 0.00061 20.0 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ACT04131.1 - 0.015 15.2 0.1 0.068 13.1 0.1 1.8 1 1 0 1 1 1 0 Glyoxalase-like domain CppA_N PF14506.6 ACT04131.1 - 0.023 14.8 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 CppA N-terminal YCII PF03795.14 ACT04132.1 - 6.7e-11 42.5 0.0 8.8e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain UIM PF02809.20 ACT04132.1 - 0.24 11.4 0.2 0.24 11.4 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif Sigma70_r4_2 PF08281.12 ACT04133.1 - 3.7e-11 42.5 3.2 2.8e-10 39.7 0.2 3.1 3 0 0 3 3 3 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACT04133.1 - 1.3e-10 40.9 0.1 2.7e-10 39.8 0.1 1.6 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 ACT04133.1 - 5e-05 22.7 1.8 0.00016 21.1 0.1 2.6 3 0 0 3 3 3 1 Sigma-70, region 4 TPR_2 PF07719.17 ACT04133.1 - 0.00013 21.8 0.8 0.0013 18.6 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ACT04133.1 - 0.0021 18.2 0.0 0.0069 16.5 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat Sigma70_ECF PF07638.11 ACT04133.1 - 0.0075 16.2 0.9 0.02 14.8 0.7 1.7 2 0 0 2 2 2 1 ECF sigma factor TPR_7 PF13176.6 ACT04133.1 - 0.013 15.5 0.4 0.054 13.5 0.4 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 ACT04133.1 - 0.022 14.9 1.0 0.1 12.7 1.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat GerE PF00196.19 ACT04133.1 - 0.038 13.6 0.0 0.082 12.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family TPR_1 PF00515.28 ACT04133.1 - 0.04 13.7 0.8 0.21 11.5 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat HTH_40 PF14493.6 ACT04133.1 - 0.12 12.8 0.1 0.57 10.7 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 ACT04133.1 - 0.16 11.8 3.4 0.51 10.2 0.2 3.2 3 0 0 3 3 3 0 Homeodomain-like domain TPR_16 PF13432.6 ACT04133.1 - 0.31 11.7 7.8 0.11 13.2 1.3 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ACT04133.1 - 6.7 6.7 6.3 2.5 8.1 1.6 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat YCII PF03795.14 ACT04134.1 - 1.9e-22 79.5 0.1 2.6e-22 79.0 0.1 1.2 1 0 0 1 1 1 1 YCII-related domain Abhydrolase_6 PF12697.7 ACT04135.1 - 4.2e-19 70.0 0.1 5e-19 69.8 0.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ACT04135.1 - 1.1e-06 28.2 0.0 4.4e-05 22.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ACT04135.1 - 2.9e-06 27.1 0.0 0.00021 21.0 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 ACT04135.1 - 0.017 15.2 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein tRNA_edit PF04073.15 ACT04136.1 - 4.1e-28 97.9 0.0 4.9e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain Glyco_hydro_115 PF15979.5 ACT04137.1 - 1e-64 219.1 0.0 1.5e-64 218.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 115 SBP_bac_8 PF13416.6 ACT04138.1 - 1.4e-28 100.5 15.3 1.4e-28 100.5 15.3 1.6 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT04138.1 - 3.2e-27 96.3 18.0 6.6e-27 95.3 18.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT04138.1 - 1.3e-05 24.8 0.2 0.15 11.5 0.0 2.5 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein Response_reg PF00072.24 ACT04139.1 - 1.5e-22 79.8 0.1 3.7e-22 78.6 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 ACT04139.1 - 3e-18 65.4 0.3 3.1e-08 33.5 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 ACT04139.1 - 4.4e-18 65.3 0.0 1e-17 64.2 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain GGDEF_2 PF17853.1 ACT04139.1 - 0.0015 18.8 0.0 0.0032 17.7 0.0 1.5 1 0 0 1 1 1 1 GGDEF-like domain Rrf2 PF02082.20 ACT04139.1 - 0.043 14.2 0.1 0.11 12.8 0.1 1.7 1 0 0 1 1 1 0 Transcriptional regulator HTH_25 PF13413.6 ACT04139.1 - 0.084 12.7 0.3 1.9 8.4 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain His_kinase PF06580.13 ACT04140.1 - 3.2e-24 85.0 0.8 7.1e-24 83.9 0.8 1.6 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT04140.1 - 4.2e-08 33.3 3.3 7.6e-08 32.4 3.3 1.4 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT04140.1 - 0.0033 17.9 0.0 0.014 15.9 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT04140.1 - 0.006 16.9 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 HAMP domain GBP PF02263.19 ACT04140.1 - 0.22 10.8 2.4 0.61 9.3 0.0 2.4 2 0 0 2 2 2 0 Guanylate-binding protein, N-terminal domain BPD_transp_1 PF00528.22 ACT04141.1 - 1.3e-18 67.4 25.2 3.2e-18 66.1 14.5 2.2 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04142.1 - 1e-10 41.7 26.3 1.5e-10 41.1 23.2 2.2 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component SLH PF00395.20 ACT04143.1 - 2.1e-34 117.2 4.5 2.8e-11 43.3 0.1 4.0 3 0 0 3 3 3 3 S-layer homology domain Cadherin-like PF12733.7 ACT04143.1 - 3.5e-31 107.6 9.6 4.4e-17 62.4 0.4 7.4 7 1 1 8 8 8 2 Cadherin-like beta sandwich domain CarboxypepD_reg PF13620.6 ACT04143.1 - 2.7e-23 82.1 17.6 2e-13 50.4 3.0 6.2 5 2 0 5 5 5 2 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 ACT04143.1 - 7.2e-10 38.7 13.8 8.8e-06 25.6 0.3 3.7 3 0 0 3 3 3 2 CarboxypepD_reg-like domain Beta_helix PF13229.6 ACT04143.1 - 3.6e-07 30.2 11.7 3.6e-07 30.2 11.7 6.3 4 1 1 5 5 5 2 Right handed beta helix region Big_1 PF02369.16 ACT04143.1 - 0.0083 16.1 0.8 0.0083 16.1 0.8 9.6 6 2 3 9 9 9 2 Bacterial Ig-like domain (group 1) MetallophosN PF16371.5 ACT04143.1 - 0.047 14.0 0.7 0.41 10.9 0.2 3.0 2 0 0 2 2 2 0 N terminal of Calcineurin-like phosphoesterase DUF2012 PF09430.10 ACT04143.1 - 0.15 12.2 0.2 6 7.0 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2012) Secretin_N_2 PF07655.13 ACT04143.1 - 3.4 8.3 15.7 0.96 10.0 9.0 3.2 2 0 0 2 2 2 0 Secretin N-terminal domain fn3 PF00041.21 ACT04144.1 - 1.3e-06 28.6 4.4 4.1e-05 23.8 0.8 3.7 2 1 0 2 2 2 1 Fibronectin type III domain GH115_C PF17829.1 ACT04144.1 - 1.1e-05 25.3 1.3 0.003 17.4 0.3 3.2 2 1 0 2 2 2 2 Gylcosyl hydrolase family 115 C-terminal domain RGI_lyase PF18370.1 ACT04144.1 - 0.00015 22.0 2.8 0.00041 20.6 1.8 2.3 1 1 1 2 2 2 1 Rhamnogalacturonan I lyases beta-sheet domain Clathrin_H_link PF13838.6 ACT04144.1 - 0.073 13.0 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Clathrin-H-link TNFR_16_TM PF18422.1 ACT04145.1 - 6.1 6.9 13.1 0.12 12.4 3.0 2.7 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain Ligase_CoA PF00549.19 ACT04147.1 - 0.013 15.4 1.1 1.2 8.9 0.1 2.0 2 0 0 2 2 2 0 CoA-ligase SLATT_4 PF18186.1 ACT04147.1 - 0.065 12.9 0.1 0.082 12.5 0.1 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 SBP_bac_5 PF00496.22 ACT04148.1 - 1.7e-42 145.8 0.0 2.5e-42 145.2 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle SgrR_N PF12793.7 ACT04148.1 - 4.4e-26 91.4 0.0 9e-26 90.4 0.0 1.5 1 0 0 1 1 1 1 Sugar transport-related sRNA regulator N-term HTH_27 PF13463.6 ACT04148.1 - 0.082 13.4 0.0 0.35 11.4 0.0 2.1 2 0 0 2 2 2 0 Winged helix DNA-binding domain BLACT_WH PF17778.1 ACT04148.1 - 0.15 12.0 0.5 2.7 8.1 0.0 2.6 3 0 0 3 3 3 0 Beta-lactamase associated winged helix domain PAP2 PF01569.21 ACT04150.1 - 2.2e-21 76.1 11.3 2.2e-21 76.1 11.3 2.8 2 2 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 ACT04150.1 - 5e-07 29.6 10.2 5e-07 29.6 10.2 2.5 2 1 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 ACT04150.1 - 0.02 15.4 5.9 0.02 15.4 5.9 2.8 3 0 0 3 3 3 0 PAP2 superfamily C-terminal MerC PF03203.14 ACT04150.1 - 0.43 11.1 9.7 0.092 13.2 3.9 2.4 1 1 2 3 3 3 0 MerC mercury resistance protein TrbC PF04956.13 ACT04150.1 - 6.9 7.0 13.2 3.1 8.1 1.5 3.1 2 1 0 2 2 2 0 TrbC/VIRB2 family RGI_lyase PF18370.1 ACT04151.1 - 7.4e-34 115.9 21.8 1.5e-31 108.5 0.0 7.5 7 0 0 7 7 7 1 Rhamnogalacturonan I lyases beta-sheet domain fn3 PF00041.21 ACT04151.1 - 4.3e-15 55.8 19.4 7.8e-05 22.9 0.0 6.8 6 1 0 6 6 6 3 Fibronectin type III domain Lipase_GDSL_2 PF13472.6 ACT04151.1 - 4.6e-12 46.7 0.1 1e-11 45.6 0.1 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family ChitinaseA_N PF08329.10 ACT04151.1 - 5.2e-10 39.1 7.6 0.00016 21.3 0.2 4.7 4 1 1 5 5 5 2 Chitinase A, N-terminal domain FG-GAP PF01839.23 ACT04151.1 - 3.2e-07 30.4 15.7 0.043 14.0 1.3 4.0 3 0 0 3 3 3 3 FG-GAP repeat Lipase_GDSL PF00657.22 ACT04151.1 - 0.00031 20.8 0.0 0.00063 19.8 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase VCBS PF13517.6 ACT04151.1 - 0.0013 19.3 19.9 0.016 15.8 1.0 5.8 5 1 1 6 6 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Laminin_G_3 PF13385.6 ACT04151.1 - 0.0056 16.8 7.9 0.28 11.3 0.6 4.7 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily PQQ PF01011.21 ACT04151.1 - 0.057 13.4 2.3 15 5.7 0.1 4.2 3 0 0 3 3 3 0 PQQ enzyme repeat ComJ PF11033.8 ACT04151.1 - 0.13 11.9 0.2 33 4.2 0.0 3.4 4 0 0 4 4 4 0 Competence protein J (ComJ) PilX PF13681.6 ACT04151.1 - 3.5 8.1 9.0 6.1 7.3 0.1 4.6 4 0 0 4 4 4 0 Type IV pilus assembly protein PilX C-term DUF4836 PF16120.5 ACT04152.1 - 0.018 14.0 0.1 0.022 13.7 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4836) HTH_20 PF12840.7 ACT04153.1 - 7.5e-15 54.7 0.0 1.1e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 ACT04153.1 - 1.8e-13 50.1 0.0 2.7e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 ACT04153.1 - 1.9e-08 34.0 0.0 2.7e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 ACT04153.1 - 8.1e-08 32.0 0.0 1.2e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 ACT04153.1 - 4.9e-06 26.0 0.2 1e-05 24.9 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 ACT04153.1 - 4.5e-05 23.3 0.0 8.3e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 MarR family LexA_DNA_bind PF01726.16 ACT04153.1 - 0.0005 19.8 0.0 0.001 18.8 0.0 1.6 1 0 0 1 1 1 1 LexA DNA binding domain HTH_Crp_2 PF13545.6 ACT04153.1 - 0.00051 20.0 0.0 0.00079 19.4 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_IclR PF09339.10 ACT04153.1 - 0.00056 19.7 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_11 PF08279.12 ACT04153.1 - 0.0012 18.7 0.0 0.0023 17.9 0.0 1.5 1 0 0 1 1 1 1 HTH domain Fe_dep_repress PF01325.19 ACT04153.1 - 0.0021 18.2 0.2 0.0078 16.4 0.0 1.8 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain Rrf2 PF02082.20 ACT04153.1 - 0.0046 17.3 0.0 0.0071 16.7 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator Sigma70_r4 PF04545.16 ACT04153.1 - 0.015 14.8 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 FaeA PF04703.12 ACT04153.1 - 0.016 15.6 0.0 0.028 14.8 0.0 1.4 1 0 0 1 1 1 0 FaeA-like protein TFIIE_beta PF02186.15 ACT04153.1 - 0.044 14.1 0.1 0.1 12.9 0.0 1.7 2 0 0 2 2 2 0 TFIIE beta subunit core domain HTH_10 PF04967.12 ACT04153.1 - 0.054 13.3 0.0 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 HTH DNA binding domain HTH_28 PF13518.6 ACT04153.1 - 0.062 13.4 0.0 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_AsnC-type PF13404.6 ACT04153.1 - 0.076 12.9 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_45 PF14947.6 ACT04153.1 - 0.088 12.8 0.0 12 5.9 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix HTH_CodY PF08222.11 ACT04153.1 - 0.091 12.3 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 CodY helix-turn-helix domain AHSA1 PF08327.11 ACT04154.1 - 3.6e-23 82.2 0.0 4.2e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Secretin_N_2 PF07655.13 ACT04155.1 - 0.013 16.0 12.8 0.013 16.0 12.8 1.5 2 0 0 2 2 2 0 Secretin N-terminal domain Zip PF02535.22 ACT04155.1 - 0.042 13.0 0.2 0.052 12.8 0.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SMN PF06003.12 ACT04155.1 - 0.043 13.1 1.9 0.05 12.9 1.9 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) OsmC PF02566.19 ACT04156.1 - 1e-17 64.4 0.1 1.4e-17 64.0 0.1 1.1 1 0 0 1 1 1 1 OsmC-like protein LRR_4 PF12799.7 ACT04157.1 - 2.2 8.9 9.0 15 6.1 0.4 3.4 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) LtrA PF06772.11 ACT04158.1 - 4.5e-109 364.9 38.5 5.1e-109 364.7 38.5 1.0 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) TetR_C_16 PF17920.1 ACT04158.1 - 0.16 12.3 0.8 0.41 10.9 0.0 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Cu_amine_oxidN1 PF07833.11 ACT04159.1 - 3.1e-09 37.2 0.3 3.3e-08 33.9 0.1 2.5 2 1 0 2 2 2 1 Copper amine oxidase N-terminal domain N6_N4_Mtase PF01555.18 ACT04159.1 - 0.0027 17.5 0.5 0.075 12.7 0.1 2.0 1 1 1 2 2 2 2 DNA methylase DUF1963 PF09234.10 ACT04160.1 - 0.0082 16.6 0.0 0.02 15.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1963) NusA_N PF08529.11 ACT04161.1 - 0.00094 19.5 0.5 0.13 12.7 0.1 2.4 2 0 0 2 2 2 1 NusA N-terminal domain HTH_40 PF14493.6 ACT04161.1 - 0.002 18.5 0.5 0.058 13.8 0.2 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_10 PF04967.12 ACT04161.1 - 0.0023 17.7 0.7 1.6 8.6 0.0 2.5 2 0 0 2 2 2 2 HTH DNA binding domain Mg_chelatase_C PF13335.6 ACT04161.1 - 0.0027 18.3 0.6 0.19 12.4 0.1 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI C-terminal HTH_Tnp_ISL3 PF13542.6 ACT04161.1 - 0.0097 15.3 0.1 0.088 12.2 0.0 2.6 2 1 1 3 3 3 1 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 ACT04161.1 - 0.019 14.7 0.1 1.2 9.1 0.0 2.6 2 1 0 2 2 2 0 Homeodomain-like domain DUF433 PF04255.14 ACT04161.1 - 0.02 14.8 0.2 7.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF433) HTH_35 PF13693.6 ACT04161.1 - 0.02 14.9 0.2 9.4 6.4 0.0 2.4 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding LacI PF00356.21 ACT04161.1 - 0.027 14.3 2.1 1.8 8.4 0.7 2.5 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family GerE PF00196.19 ACT04161.1 - 0.033 13.7 0.4 8.4 6.0 0.1 2.3 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family LysM PF01476.20 ACT04161.1 - 0.048 13.7 0.2 0.49 10.5 0.0 2.5 2 0 0 2 2 2 0 LysM domain HTH_Tnp_1 PF01527.20 ACT04161.1 - 0.048 14.0 0.0 18 5.8 0.0 2.6 2 0 0 2 2 2 0 Transposase HTH_7 PF02796.15 ACT04161.1 - 0.049 13.7 0.0 8 6.6 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase GRP PF07172.11 ACT04161.1 - 0.089 13.5 2.2 8.8 7.1 0.0 2.9 3 0 0 3 3 3 0 Glycine rich protein family IF2_N PF04760.15 ACT04161.1 - 0.093 12.6 0.8 20 5.1 0.0 2.9 2 1 1 3 3 3 0 Translation initiation factor IF-2, N-terminal region HTH_29 PF13551.6 ACT04161.1 - 0.1 12.7 1.4 3.7 7.6 0.0 3.3 3 1 1 4 4 4 0 Winged helix-turn helix ScdA_N PF04405.14 ACT04161.1 - 0.13 11.9 0.9 10 5.9 0.1 3.1 2 1 1 3 3 3 0 Domain of Unknown function (DUF542) HTH_38 PF13936.6 ACT04161.1 - 0.14 12.0 0.0 6.9 6.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Clp_N PF02861.20 ACT04161.1 - 0.21 11.7 1.3 11 6.2 0.1 3.0 2 1 1 3 3 3 0 Clp amino terminal domain, pathogenicity island component HTH_15 PF12324.8 ACT04161.1 - 0.38 10.7 4.5 6.3 6.8 0.6 3.3 2 1 1 3 3 3 0 Helix-turn-helix domain of alkylmercury lyase OmdA PF13376.6 ACT04162.1 - 2.8e-21 75.3 0.1 5e-21 74.5 0.1 1.4 1 0 0 1 1 1 1 Bacteriocin-protection, YdeI or OmpD-Associated DUF1905 PF08922.11 ACT04162.1 - 3.4e-20 71.9 0.2 8.3e-20 70.6 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1905) DUF3443 PF11925.8 ACT04162.1 - 0.044 12.6 0.0 0.064 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3443) DUF562 PF04763.12 ACT04163.1 - 0.093 12.2 0.1 0.18 11.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF562) HTH_26 PF13443.6 ACT04164.1 - 6.7e-22 77.7 0.2 8.1e-22 77.4 0.2 1.0 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_3 PF01381.22 ACT04164.1 - 1.1e-05 25.4 0.0 1.4e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 ACT04164.1 - 3.9e-05 23.6 0.0 4.6e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 ACT04164.1 - 5.4e-05 23.1 0.1 6.6e-05 22.8 0.1 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ACT04164.1 - 0.0021 18.4 0.0 0.0026 18.1 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 ACT04164.1 - 0.017 15.0 0.1 0.035 14.0 0.0 1.5 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 ACT04164.1 - 0.068 13.2 0.0 0.44 10.6 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_35 PF13693.6 ACT04164.1 - 0.084 12.9 0.0 0.14 12.2 0.0 1.4 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding FliMN_C PF01052.20 ACT04164.1 - 0.088 12.8 0.3 5.8 7.0 0.1 2.5 2 1 1 3 3 3 0 Type III flagellar switch regulator (C-ring) FliN C-term DUF2975 PF11188.8 ACT04165.1 - 1.1e-36 125.6 9.8 2.3e-36 124.6 9.5 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2975) Ninjurin PF04923.12 ACT04165.1 - 0.04 13.8 0.5 0.04 13.8 0.5 1.6 2 0 0 2 2 2 0 Ninjurin DUF3522 PF12036.8 ACT04165.1 - 0.053 13.8 1.3 0.078 13.3 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3522) Aldedh PF00171.22 ACT04167.1 - 1.6e-158 528.0 4.4 1.9e-158 527.8 4.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ACT04167.1 - 1.4e-05 24.3 0.0 3.3e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) HTH_18 PF12833.7 ACT04168.1 - 1.9e-17 63.3 0.0 3e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04168.1 - 9.8e-09 35.1 0.0 2.1e-05 24.5 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family EF-G-binding_N PF07299.11 ACT04168.1 - 0.071 13.6 0.3 7.7 7.1 0.3 2.2 1 1 1 2 2 2 0 Elongation factor G-binding protein, N-terminal AHSA1 PF08327.11 ACT04169.1 - 2.5e-12 47.1 0.1 2.9e-12 46.9 0.1 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein CBM9_2 PF16011.5 ACT04171.1 - 6.3e-39 133.7 0.0 7.6e-39 133.5 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate-binding family 9 CBM9_1 PF06452.11 ACT04171.1 - 0.0011 18.9 0.0 0.0027 17.6 0.0 1.5 2 0 0 2 2 2 1 Carbohydrate family 9 binding domain-like GFO_IDH_MocA PF01408.22 ACT04172.1 - 1.2e-22 81.0 0.0 2.5e-22 79.9 0.0 1.6 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT04172.1 - 1.3e-10 41.3 0.1 2.5e-10 40.4 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Sacchrp_dh_NADP PF03435.18 ACT04172.1 - 0.021 15.1 0.1 0.072 13.4 0.1 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AP_endonuc_2 PF01261.24 ACT04173.1 - 9.2e-31 106.9 0.0 1.2e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel PRMT5_TIM PF17285.2 ACT04173.1 - 0.035 13.3 0.0 0.046 12.9 0.0 1.2 1 0 0 1 1 1 0 PRMT5 TIM barrel domain HTH_18 PF12833.7 ACT04174.1 - 3.3e-21 75.3 0.0 6.3e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04174.1 - 6.2e-15 54.9 0.0 3.6e-08 33.3 0.0 2.6 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT04174.1 - 8.2e-11 41.9 1.1 2.1e-10 40.6 0.3 1.9 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT04174.1 - 4.5e-06 26.3 1.3 7.5e-06 25.6 1.3 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 ACT04174.1 - 0.018 14.8 0.0 0.08 12.7 0.0 1.9 1 1 1 2 2 2 0 Cupin Cupin_3 PF05899.12 ACT04174.1 - 0.019 14.6 0.2 0.046 13.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Hid1 PF12722.7 ACT04174.1 - 0.058 11.5 0.1 0.08 11.1 0.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Peripla_BP_3 PF13377.6 ACT04175.1 - 6.1e-43 147.0 0.0 1.5e-41 142.5 0.0 2.1 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_1 PF00532.21 ACT04175.1 - 6.1e-32 111.2 0.0 8.2e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family LacI PF00356.21 ACT04175.1 - 2.6e-17 62.3 0.5 6.5e-17 61.0 0.5 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_4 PF13407.6 ACT04175.1 - 7.6e-15 55.2 0.1 1.4e-14 54.3 0.1 1.4 1 0 0 1 1 1 1 Periplasmic binding protein domain HTH_24 PF13412.6 ACT04175.1 - 0.0015 18.0 0.0 0.007 15.9 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_23 PF13384.6 ACT04175.1 - 0.0033 17.2 0.0 0.034 13.9 0.0 2.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_AraC PF00165.23 ACT04175.1 - 0.0049 16.9 0.0 0.041 14.0 0.0 2.4 3 0 0 3 3 3 1 Bacterial regulatory helix-turn-helix proteins, AraC family Sigma54_DBD PF04552.13 ACT04175.1 - 0.0061 16.3 0.2 0.022 14.5 0.0 2.0 2 0 0 2 2 2 1 Sigma-54, DNA binding domain HTH_3 PF01381.22 ACT04175.1 - 0.0061 16.6 0.1 0.027 14.5 0.1 2.2 1 1 0 1 1 1 1 Helix-turn-helix HTH_Tnp_ISL3 PF13542.6 ACT04175.1 - 0.0064 15.9 0.0 0.015 14.7 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 Crp PF00325.20 ACT04175.1 - 0.017 14.8 0.0 0.034 13.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family HTH_38 PF13936.6 ACT04175.1 - 0.04 13.7 0.0 0.2 11.4 0.0 2.2 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2175 PF09943.9 ACT04175.1 - 0.04 14.2 0.6 4.5 7.6 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) HTH_10 PF04967.12 ACT04175.1 - 0.04 13.7 0.2 0.34 10.8 0.0 2.3 2 0 0 2 2 2 0 HTH DNA binding domain DUF560 PF04575.13 ACT04175.1 - 0.059 12.8 0.0 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF560) HTH_Crp_2 PF13545.6 ACT04175.1 - 0.062 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_IclR PF09339.10 ACT04175.1 - 0.065 13.0 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 IclR helix-turn-helix domain RuvX PF03652.15 ACT04175.1 - 0.12 12.8 0.2 0.33 11.3 0.1 1.8 2 0 0 2 2 2 0 Holliday junction resolvase MarR PF01047.22 ACT04175.1 - 0.12 12.4 0.1 0.31 11.0 0.1 1.8 1 0 0 1 1 1 0 MarR family Sigma70_r4 PF04545.16 ACT04175.1 - 0.14 11.7 0.0 0.36 10.4 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_AsnC-type PF13404.6 ACT04175.1 - 0.15 11.9 0.0 0.43 10.4 0.0 1.8 2 0 0 2 2 1 0 AsnC-type helix-turn-helix domain TnsD PF15978.5 ACT04175.1 - 0.2 10.6 0.8 0.4 9.6 0.8 1.4 1 1 0 1 1 1 0 Tn7-like transposition protein D SBP_bac_8 PF13416.6 ACT04176.1 - 4.4e-37 128.4 12.3 5.8e-37 128.0 12.3 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT04176.1 - 5.7e-33 115.2 15.0 8.9e-33 114.6 15.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT04176.1 - 1.4e-07 31.2 1.0 0.0001 21.8 0.1 2.4 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT04176.1 - 8.8e-06 25.6 0.0 0.00012 21.9 0.0 2.3 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT04177.1 - 4.8e-21 75.3 14.3 4.8e-21 75.3 14.3 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04178.1 - 1.7e-15 57.2 22.4 1.7e-15 57.2 22.4 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component SPW PF03779.14 ACT04178.1 - 0.47 10.1 6.1 0.16 11.6 0.8 2.5 2 0 0 2 2 2 0 SPW repeat GFO_IDH_MocA PF01408.22 ACT04179.1 - 2.1e-25 89.9 0.1 3.6e-25 89.1 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT04179.1 - 2.7e-10 40.3 0.0 1.3e-09 38.1 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 ACT04179.1 - 0.0056 17.3 0.1 0.01 16.5 0.1 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ACT04179.1 - 0.078 13.4 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ACT04179.1 - 0.095 12.9 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase CoA_binding PF02629.19 ACT04179.1 - 0.1 13.3 0.0 0.22 12.2 0.0 1.5 1 0 0 1 1 1 0 CoA binding domain SLH PF00395.20 ACT04180.1 - 7.4e-36 121.9 0.2 4.1e-10 39.5 0.1 3.9 3 0 0 3 3 3 3 S-layer homology domain DUF4832 PF16116.5 ACT04180.1 - 1.9e-28 99.8 0.0 5.4e-28 98.3 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4832) Glyco_hydro_42 PF02449.15 ACT04180.1 - 1e-07 31.7 0.2 1.6e-07 31.0 0.2 1.2 1 0 0 1 1 1 1 Beta-galactosidase DUF4874 PF16173.5 ACT04180.1 - 0.0005 19.8 0.0 0.00098 18.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4874) fn3 PF00041.21 ACT04181.1 - 5.2e-26 90.8 14.8 6.9e-09 35.9 1.0 3.7 3 0 0 3 3 3 3 Fibronectin type III domain RGI_lyase PF18370.1 ACT04181.1 - 2.3e-18 66.3 10.3 2.1e-06 27.9 0.4 4.1 4 0 0 4 4 4 3 Rhamnogalacturonan I lyases beta-sheet domain DUF4959 PF16323.5 ACT04181.1 - 3.7e-12 46.5 9.0 0.0009 19.5 0.3 3.5 2 1 1 3 3 3 3 Domain of unknown function (DUF4959) fn3_2 PF16893.5 ACT04181.1 - 5.9e-07 29.5 0.3 0.16 12.1 0.0 3.7 3 0 0 3 3 3 2 Fibronectin type III domain DUF4998 PF16389.5 ACT04181.1 - 2.9e-06 27.0 0.0 0.19 11.3 0.0 3.5 3 0 0 3 3 3 3 Domain of unknown function Pur_ac_phosph_N PF16656.5 ACT04181.1 - 0.0012 19.4 10.8 1.1 9.9 0.1 4.0 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 ACT04181.1 - 0.012 16.0 0.5 22 5.5 0.0 3.8 4 0 0 4 4 4 0 Uncharacterised conserved protein (DUF2369) AMP-binding PF00501.28 ACT04182.1 - 6.3e-100 334.7 0.0 8.9e-100 334.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ACT04182.1 - 1.1e-51 175.4 0.0 1.6e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 ACT04182.1 - 3.2e-13 49.7 0.0 6.4e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ACT04182.1 - 2.3e-10 40.4 0.0 3.6e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase AMP-binding_C PF13193.6 ACT04182.1 - 5.5e-08 33.7 0.0 1.4e-07 32.4 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.19 ACT04182.1 - 1.6e-06 27.3 0.0 1.1e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 ACT04182.1 - 5.5e-06 26.7 0.0 1.4e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.20 ACT04182.1 - 2.7e-05 23.1 0.1 0.0013 17.5 0.0 2.3 2 0 0 2 2 2 1 Condensation domain Polysacc_synt_2 PF02719.15 ACT04182.1 - 0.0017 17.5 0.0 0.0035 16.5 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ACT04182.1 - 0.0054 15.9 0.0 0.012 14.7 0.0 1.5 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ACT04182.1 - 0.012 15.5 0.0 0.05 13.5 0.0 1.9 1 1 0 1 1 1 0 NAD(P)H-binding KR PF08659.10 ACT04182.1 - 0.036 14.0 0.1 0.078 12.9 0.1 1.5 1 0 0 1 1 1 0 KR domain MCPsignal PF00015.21 ACT04183.1 - 8.7e-45 152.6 44.8 4.2e-43 147.1 23.8 4.0 1 1 3 4 4 4 3 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 ACT04183.1 - 1.6e-07 31.5 0.2 2.8e-06 27.6 0.0 3.2 3 0 0 3 3 3 1 HAMP domain DUF948 PF06103.11 ACT04183.1 - 7.6e-05 22.9 36.7 0.0023 18.1 1.1 6.1 2 1 4 6 6 6 3 Bacterial protein of unknown function (DUF948) dCache_1 PF02743.18 ACT04183.1 - 0.00026 20.9 0.3 0.00026 20.9 0.3 4.3 3 2 1 4 4 4 1 Cache domain DUF3278 PF11683.8 ACT04183.1 - 0.03 14.4 1.4 1.2 9.2 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) Retrotran_gag_2 PF14223.6 ACT04183.1 - 0.095 12.4 4.6 0.1 12.2 0.2 2.8 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type Sgf11_N PF18519.1 ACT04183.1 - 0.16 11.6 3.6 3.7 7.2 0.3 3.5 3 0 0 3 3 3 0 SAGA-associated factor 11 N-terminal domain EzrA PF06160.12 ACT04183.1 - 0.25 9.5 30.0 0.91 7.6 8.1 3.6 2 2 1 3 3 3 0 Septation ring formation regulator, EzrA ISG65-75 PF11727.8 ACT04183.1 - 1.2 8.3 23.0 0.023 14.0 5.6 3.1 1 1 2 3 3 3 0 Invariant surface glycoprotein DUF4874 PF16173.5 ACT04183.1 - 1.7 8.3 8.8 0.64 9.7 2.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4874) DUF1664 PF07889.12 ACT04183.1 - 3 7.9 34.5 0.39 10.8 4.0 4.6 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Phage_GPO PF05929.11 ACT04183.1 - 5.2 6.6 27.7 1.1 8.8 0.6 3.8 1 1 3 4 4 4 0 Phage capsid scaffolding protein (GPO) serine peptidase Glyco_hydro_38 PF18438.1 ACT04184.1 - 2.6e-39 133.7 0.0 5.7e-39 132.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain 1 Glyco_hydro_38N PF01074.22 ACT04184.1 - 5.2e-29 101.5 0.0 8.7e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ACT04184.1 - 2.5e-22 80.0 0.0 4.8e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ACT04184.1 - 4.2e-13 49.3 0.3 9e-13 48.2 0.3 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ACT04184.1 - 3.4e-05 23.9 0.0 0.0001 22.3 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain YccJ PF13993.6 ACT04184.1 - 0.0091 16.3 0.9 0.87 10.0 0.3 3.2 2 0 0 2 2 2 1 YccJ-like protein Glyco_hydro_42 PF02449.15 ACT04185.1 - 5.3e-09 35.9 1.0 4.5e-07 29.5 0.2 2.2 2 0 0 2 2 2 2 Beta-galactosidase Cellulase PF00150.18 ACT04185.1 - 1.1e-06 28.3 0.3 0.0044 16.5 0.0 2.4 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) DUF4350 PF14258.6 ACT04185.1 - 0.016 15.6 0.6 3.7 8.0 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4350) Glyco_hydro_125 PF06824.11 ACT04186.1 - 8.4e-152 505.8 0.0 9.6e-152 505.7 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) BPD_transp_1 PF00528.22 ACT04187.1 - 1.1e-12 48.1 19.0 1.1e-12 48.1 19.0 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Phage_holin_3_7 PF05449.11 ACT04187.1 - 0.0039 17.2 0.5 0.013 15.5 0.5 1.9 1 0 0 1 1 1 1 Putative 3TM holin, Phage_holin_3 Ycf70 PF17382.2 ACT04187.1 - 0.0048 17.3 0.3 0.017 15.5 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized Ycf70-like BPD_transp_1 PF00528.22 ACT04188.1 - 1.1e-15 57.9 15.0 1.1e-15 57.9 15.0 2.6 1 1 2 3 3 3 1 Binding-protein-dependent transport system inner membrane component DUF21 PF01595.20 ACT04188.1 - 0.035 13.8 2.0 0.037 13.7 0.6 1.8 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain DUF3502 PF12010.8 ACT04189.1 - 5e-41 140.4 0.8 1.3e-40 139.0 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) SBP_bac_8 PF13416.6 ACT04189.1 - 8.2e-16 58.6 12.4 1.7e-15 57.6 12.4 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT04189.1 - 3.7e-11 43.5 12.1 1.1e-10 42.0 12.1 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein Response_reg PF00072.24 ACT04190.1 - 1.2e-27 96.3 0.0 3.2e-26 91.7 0.0 2.4 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT04190.1 - 4.4e-20 71.7 0.0 9e-20 70.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04190.1 - 9.8e-13 47.9 0.1 3.6e-05 23.7 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT04190.1 - 4.1e-09 36.7 0.1 1.3e-08 35.1 0.1 1.9 1 0 0 1 1 1 1 GGDEF-like domain DUF3144 PF11342.8 ACT04190.1 - 0.039 14.2 0.3 0.11 12.8 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3144) His_kinase PF06580.13 ACT04191.1 - 5.8e-21 74.6 2.3 8.9e-21 74.0 0.1 2.5 3 0 0 3 3 3 1 Histidine kinase dCache_1 PF02743.18 ACT04191.1 - 2.7e-10 40.5 6.6 5.3e-10 39.5 6.6 1.4 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 ACT04191.1 - 1.4e-09 38.2 0.4 4.6e-09 36.5 0.4 1.9 1 0 0 1 1 1 1 HAMP domain HATPase_c PF02518.26 ACT04191.1 - 1.4e-09 38.4 0.0 2.8e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT04191.1 - 0.00066 19.5 0.0 0.0021 17.9 0.0 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF4446 PF14584.6 ACT04191.1 - 0.0013 18.7 1.8 0.0036 17.3 0.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4446) HATPase_c_2 PF13581.6 ACT04191.1 - 0.076 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Esterase PF00756.20 ACT04192.1 - 5.1e-37 127.9 0.1 5.9e-37 127.7 0.1 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 ACT04192.1 - 0.16 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase LPAM_1 PF08139.12 ACT04193.1 - 0.0078 16.6 4.6 0.014 15.8 4.6 1.5 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site CBFNT PF08143.11 ACT04193.1 - 1 10.8 8.5 2.4 9.7 8.5 1.5 1 0 0 1 1 1 0 CBFNT (NUC161) domain GFO_IDH_MocA PF01408.22 ACT04195.1 - 4.2e-17 63.1 0.0 6.7e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT04195.1 - 5e-12 45.8 0.0 9.2e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Sacchrp_dh_NADP PF03435.18 ACT04195.1 - 9e-05 22.7 0.0 0.00019 21.7 0.0 1.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_3 PF03447.16 ACT04195.1 - 0.079 13.6 0.0 0.12 13.0 0.0 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain CoA_binding PF02629.19 ACT04195.1 - 0.086 13.5 0.0 0.24 12.1 0.0 1.8 2 0 0 2 2 2 0 CoA binding domain ThuA PF06283.11 ACT04196.1 - 1.3e-34 120.3 0.1 1.6e-34 120.0 0.1 1.1 1 0 0 1 1 1 1 Trehalose utilisation SBP_bac_1 PF01547.25 ACT04197.1 - 4.8e-14 53.0 8.9 4.8e-14 53.0 8.9 2.1 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT04197.1 - 4.5e-11 43.1 6.5 8.4e-11 42.2 6.5 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT04198.1 - 5.2e-07 29.6 27.6 2.6e-05 24.0 27.6 2.6 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Orf78 PF06024.12 ACT04198.1 - 0.23 11.8 2.0 0.32 11.3 0.1 2.2 2 1 0 2 2 2 0 Orf78 (ac78) BPD_transp_1 PF00528.22 ACT04199.1 - 1.5e-14 54.2 10.3 1.5e-14 54.2 10.3 2.7 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component His_kinase PF06580.13 ACT04200.1 - 1.9e-19 69.8 2.5 1.9e-19 69.8 2.5 2.8 3 0 0 3 3 3 1 Histidine kinase HATPase_c PF02518.26 ACT04200.1 - 2.4e-09 37.7 0.0 4.8e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 ACT04200.1 - 0.00024 21.0 5.1 0.00048 20.0 5.1 1.5 1 0 0 1 1 1 1 Cache domain HATPase_c_2 PF13581.6 ACT04200.1 - 0.02 14.9 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Response_reg PF00072.24 ACT04201.1 - 1.7e-21 76.5 0.0 3.9e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT04201.1 - 1.7e-19 69.9 0.0 4.9e-19 68.4 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04201.1 - 2.7e-16 59.2 0.0 2.3e-09 37.1 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family MENTAL PF10457.9 ACT04201.1 - 0.031 14.1 0.0 0.074 12.9 0.0 1.6 1 0 0 1 1 1 0 Cholesterol-capturing domain ApbA PF02558.16 ACT04202.1 - 9.8e-14 51.3 0.0 1.9e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 ACT04202.1 - 0.0012 19.3 0.1 0.0036 17.8 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 ACT04202.1 - 0.0074 16.2 0.1 0.039 13.9 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ACT04202.1 - 0.0095 16.5 0.2 0.035 14.7 0.2 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ACT04202.1 - 0.0099 16.3 0.0 0.027 14.9 0.0 1.8 1 1 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_2 PF03446.15 ACT04202.1 - 0.02 15.0 0.1 0.048 13.8 0.0 1.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox_2 PF07992.14 ACT04202.1 - 0.055 12.7 0.0 0.094 11.9 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TetR_N PF00440.23 ACT04203.1 - 1.6e-07 31.0 0.0 2.4e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_8 PF14278.6 ACT04203.1 - 0.0041 17.2 0.5 0.033 14.3 0.0 2.3 1 1 0 2 2 2 1 Transcriptional regulator C-terminal region HTH_7 PF02796.15 ACT04203.1 - 0.059 13.5 0.5 0.34 11.0 0.1 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase PDE4_UCR PF18100.1 ACT04203.1 - 0.088 13.5 0.2 0.12 13.0 0.2 1.4 1 1 0 1 1 1 0 Phosphodiesterase 4 upstream conserved regions (UCR) BPD_transp_1 PF00528.22 ACT04204.1 - 6e-16 58.7 18.6 6e-16 58.7 18.6 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04205.1 - 3.4e-06 26.9 33.2 1.3e-05 25.0 33.3 2.0 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component TM_helix PF05552.12 ACT04205.1 - 5.2 7.1 13.1 1.2 9.2 1.7 3.3 3 0 0 3 3 3 0 Conserved TM helix MHB PF16525.5 ACT04206.1 - 0.052 13.8 0.1 0.32 11.3 0.0 2.2 2 0 0 2 2 2 0 Haemophore, haem-binding LrgB PF04172.16 ACT04207.1 - 3.2e-69 232.7 10.6 3.6e-69 232.6 10.6 1.0 1 0 0 1 1 1 1 LrgB-like family Phage_holin_5_2 PF16079.5 ACT04207.1 - 0.18 12.1 0.2 0.18 12.1 0.2 2.8 2 1 1 3 3 3 0 Phage holin family Hol44, in holin superfamily V DUF697 PF05128.12 ACT04207.1 - 0.21 11.3 1.8 0.23 11.2 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF697) DUF2929 PF11151.8 ACT04207.1 - 0.7 10.2 5.4 2.3 8.6 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2929) LrgA PF03788.14 ACT04208.1 - 7.2e-27 93.2 12.8 8.7e-27 92.9 12.8 1.1 1 0 0 1 1 1 1 LrgA family FixQ PF05545.11 ACT04208.1 - 1.8 8.6 0.0 1.8 8.6 0.0 3.0 2 1 1 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ Peptidase_M56 PF05569.11 ACT04209.1 - 8.4e-65 218.9 2.4 1.3e-64 218.3 2.4 1.3 1 0 0 1 1 1 1 BlaR1 peptidase M56 NOD PF06816.13 ACT04209.1 - 0.064 12.9 0.1 0.64 9.7 0.0 2.3 2 0 0 2 2 2 0 NOTCH protein Peptidase_M48 PF01435.18 ACT04209.1 - 0.071 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M48 Tad PF13400.6 ACT04209.1 - 1.3 9.4 0.0 1.3 9.4 0.0 2.7 3 0 0 3 3 3 0 Putative Flp pilus-assembly TadE/G-like DUF4131 PF13567.6 ACT04209.1 - 6.1 6.5 6.1 34 4.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Penicillinase_R PF03965.16 ACT04210.1 - 6.3e-34 116.8 0.3 7.1e-34 116.6 0.3 1.0 1 0 0 1 1 1 1 Penicillinase repressor SMC_ScpB PF04079.16 ACT04210.1 - 0.00057 19.5 0.0 0.001 18.7 0.0 1.5 1 1 0 1 1 1 1 Segregation and condensation complex subunit ScpB TrmB PF01978.19 ACT04210.1 - 0.016 15.1 0.0 0.043 13.7 0.0 1.7 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 ACT04210.1 - 0.025 14.5 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 MarR family DUF3489 PF11994.8 ACT04210.1 - 0.035 14.2 0.0 0.062 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3489) HTH_20 PF12840.7 ACT04210.1 - 0.082 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain adh_short_C2 PF13561.6 ACT04212.1 - 3.8e-47 160.8 0.0 9.2e-47 159.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT04212.1 - 1.6e-43 148.5 0.0 2.3e-43 148.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT04212.1 - 1.8e-06 28.0 0.3 1e-05 25.5 0.2 2.2 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ACT04212.1 - 1.1e-05 25.1 0.3 4.6e-05 23.0 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ACT04212.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ACT04212.1 - 0.013 14.6 0.0 0.031 13.4 0.0 1.6 2 0 0 2 2 2 0 RmlD substrate binding domain DUF1776 PF08643.10 ACT04212.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) SnoaL_2 PF12680.7 ACT04213.1 - 4.7e-05 24.0 0.0 4.9e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain POC3_POC4 PF10448.9 ACT04213.1 - 0.029 14.4 0.0 0.033 14.2 0.0 1.2 1 0 0 1 1 1 0 20S proteasome chaperone assembly proteins 3 and 4 NTF2 PF02136.20 ACT04213.1 - 0.19 12.3 0.0 0.21 12.2 0.0 1.1 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain GFO_IDH_MocA PF01408.22 ACT04214.1 - 2.3e-20 73.6 0.0 3.8e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT04214.1 - 1.1e-09 38.3 0.0 2.3e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain ox_reductase_C PF08635.10 ACT04214.1 - 8.3e-07 28.8 0.1 7.4e-06 25.7 0.1 2.2 1 1 0 1 1 1 1 Putative oxidoreductase C terminal domain F420_oxidored PF03807.17 ACT04214.1 - 0.043 14.4 0.0 0.25 12.0 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent G6PD_N PF00479.22 ACT04214.1 - 0.074 13.7 0.0 0.13 12.9 0.0 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain HATPase_c PF02518.26 ACT04215.1 - 3.1e-19 69.5 0.0 1.9e-18 67.0 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT04215.1 - 2e-14 53.3 0.1 5.1e-14 52.1 0.0 1.8 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT04215.1 - 7.2e-13 48.7 1.4 1.3e-12 47.9 0.2 2.0 2 0 0 2 2 2 1 HAMP domain HATPase_c_5 PF14501.6 ACT04215.1 - 2.8e-05 24.0 0.0 5.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 ACT04215.1 - 0.03 14.3 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain NERD PF08378.11 ACT04215.1 - 0.033 14.7 0.0 0.063 13.7 0.0 1.4 1 0 0 1 1 1 0 Nuclease-related domain Response_reg PF00072.24 ACT04216.1 - 6e-27 94.0 1.7 8.9e-27 93.5 1.7 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT04216.1 - 5.3e-25 87.3 0.0 1e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Dala_Dala_lig_C PF07478.13 ACT04217.1 - 3.3e-68 229.3 0.0 4.3e-68 228.9 0.0 1.1 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Dala_Dala_lig_N PF01820.21 ACT04217.1 - 3.7e-26 91.6 0.0 7.4e-26 90.6 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase N-terminus CPSase_L_D2 PF02786.17 ACT04217.1 - 4.3e-05 23.1 0.0 0.00031 20.3 0.0 2.0 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain RimK PF08443.11 ACT04217.1 - 0.00023 20.8 0.0 0.62 9.6 0.0 2.2 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp PF02222.22 ACT04217.1 - 0.00035 20.2 0.0 0.00087 18.9 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 ACT04217.1 - 0.0027 17.5 0.0 0.0042 16.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_4 PF13535.6 ACT04217.1 - 0.0039 16.8 0.0 0.025 14.2 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 ACT04217.1 - 0.013 14.8 0.0 0.32 10.2 0.0 2.1 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Ala_racemase_N PF01168.20 ACT04218.1 - 5.5e-60 202.7 0.0 6.8e-60 202.4 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ala_racemase_C PF00842.21 ACT04218.1 - 2.3e-35 121.1 0.1 3.8e-35 120.4 0.1 1.4 1 0 0 1 1 1 1 Alanine racemase, C-terminal domain VanY PF02557.17 ACT04219.1 - 4.6e-30 104.1 0.0 6e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Peptidase_M15_4 PF13539.6 ACT04219.1 - 0.064 13.8 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Acyl_transf_3 PF01757.22 ACT04220.1 - 5e-19 68.5 32.4 7e-19 68.1 32.4 1.3 1 0 0 1 1 1 1 Acyltransferase family HRG PF16954.5 ACT04220.1 - 1.3 9.5 5.5 0.64 10.5 0.6 3.0 2 0 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene HTH_18 PF12833.7 ACT04221.1 - 2e-23 82.5 1.4 4.1e-23 81.4 0.4 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04221.1 - 7.2e-19 67.4 0.1 3.3e-09 36.6 0.1 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT04221.1 - 6.5e-09 35.8 0.0 1.3e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Sulfatase PF00884.23 ACT04222.1 - 5.3e-59 200.1 1.3 7.5e-59 199.6 1.3 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ACT04222.1 - 1.8e-14 54.2 1.2 1e-08 35.2 0.2 2.6 2 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 ACT04222.1 - 8e-09 35.7 3.4 9.5e-09 35.5 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) DUF229 PF02995.17 ACT04222.1 - 0.00011 21.0 0.1 0.00023 19.9 0.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF229) DUF1501 PF07394.12 ACT04222.1 - 0.18 10.8 0.0 0.3 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Glyco_hydro_2_N PF02837.18 ACT04223.1 - 1.2e-20 74.1 2.7 1.5e-20 73.8 1.1 2.0 2 1 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 ACT04223.1 - 4.7e-13 48.9 0.0 1.2e-11 44.3 0.0 2.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ACT04223.1 - 1.6e-06 28.7 0.0 3.5e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Cadherin-like PF12733.7 ACT04223.1 - 0.081 13.5 0.0 0.29 11.7 0.0 1.8 2 0 0 2 2 2 0 Cadherin-like beta sandwich domain Alpha-L-AF_C PF06964.12 ACT04224.1 - 2.5e-12 47.3 0.0 3.2e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 Alpha-L-arabinofuranosidase C-terminal domain Glyco_hydro_79n PF03662.14 ACT04224.1 - 2.9e-05 23.2 0.0 5.7e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 79, N-terminal domain DUF493 PF04359.14 ACT04224.1 - 0.05 14.2 0.0 0.11 13.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF493) Glyco_hydro_44 PF12891.7 ACT04224.1 - 0.1 12.5 1.3 0.6 10.0 1.3 2.1 1 1 0 1 1 1 0 Glycoside hydrolase family 44 BPD_transp_1 PF00528.22 ACT04225.1 - 2.3e-16 60.1 11.5 2.3e-16 60.1 11.5 2.6 1 1 2 3 3 3 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04226.1 - 9.9e-17 61.3 9.9 9.9e-17 61.3 9.9 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component MNHE PF01899.16 ACT04226.1 - 0.17 11.6 3.3 0.43 10.3 3.3 1.7 1 0 0 1 1 1 0 Na+/H+ ion antiporter subunit Gsf2 PF11055.8 ACT04226.1 - 0.24 10.1 1.6 0.39 9.4 0.3 1.8 2 0 0 2 2 2 0 Glucose signalling factor 2 SBP_bac_1 PF01547.25 ACT04227.1 - 9.9e-14 52.0 3.3 9.9e-14 52.0 3.3 1.9 2 1 0 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT04227.1 - 1.5e-12 47.9 0.6 3.1e-12 46.9 0.6 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Response_reg PF00072.24 ACT04228.1 - 8.9e-27 93.5 0.1 2.1e-26 92.3 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT04228.1 - 9.1e-20 70.7 0.1 2.5e-19 69.3 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04228.1 - 9e-14 51.1 0.3 7e-08 32.4 0.1 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family GGDEF_2 PF17853.1 ACT04228.1 - 7.3e-07 29.4 2.0 1.8e-06 28.2 2.0 1.7 1 0 0 1 1 1 1 GGDEF-like domain FleQ PF06490.11 ACT04228.1 - 0.064 13.6 0.5 1.9 8.9 0.0 3.1 3 1 1 4 4 4 0 Flagellar regulatory protein FleQ His_kinase PF06580.13 ACT04229.1 - 6.7e-22 77.6 1.2 1.5e-21 76.4 0.1 2.2 2 0 0 2 2 2 1 Histidine kinase dCache_1 PF02743.18 ACT04229.1 - 5.2e-18 65.7 0.7 9.8e-18 64.8 0.7 1.5 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 ACT04229.1 - 2.6e-10 40.8 0.0 7e-10 39.4 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT04229.1 - 0.00025 21.4 0.1 0.00077 19.8 0.0 1.9 2 0 0 2 2 2 1 HAMP domain HATPase_c_3 PF13589.6 ACT04229.1 - 0.0039 17.0 0.0 0.0087 15.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT04229.1 - 0.0099 15.8 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain S1_2 PF13509.6 ACT04229.1 - 0.036 14.1 0.0 2.2 8.4 0.0 3.1 3 0 0 3 3 3 0 S1 domain HTH_18 PF12833.7 ACT04230.1 - 9.4e-22 77.1 0.2 1.9e-21 76.1 0.2 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04230.1 - 2.2e-14 53.1 0.0 5.3e-07 29.6 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT04230.1 - 2.1e-13 50.3 0.1 4.6e-13 49.2 0.1 1.6 1 1 0 1 1 1 1 AraC-like ligand binding domain AraC_binding_2 PF14525.6 ACT04230.1 - 7.1e-08 32.3 0.5 1.1e-07 31.7 0.5 1.4 1 0 0 1 1 1 1 AraC-binding-like domain Cupin_2 PF07883.11 ACT04230.1 - 0.0044 16.7 0.0 0.0085 15.8 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 ACT04230.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.4 1 1 0 1 1 1 0 Cupin HTH_23 PF13384.6 ACT04230.1 - 0.086 12.7 0.0 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Homeodomain-like domain Glyoxalase_2 PF12681.7 ACT04231.1 - 1.2e-07 31.7 0.3 2.3e-07 30.8 0.3 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 ACT04231.1 - 9.6e-07 29.6 0.0 1.1e-06 29.4 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 ACT04231.1 - 7.2e-05 23.0 0.0 0.00058 20.0 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily SMI1_KNR4 PF09346.10 ACT04232.1 - 3.5e-05 24.2 0.2 8.8e-05 22.9 0.1 1.8 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) SUKH_5 PF14567.6 ACT04232.1 - 0.0019 17.9 0.4 0.0054 16.5 0.4 1.8 1 1 0 1 1 1 1 SMI1-KNR4 cell-wall HEAT_2 PF13646.6 ACT04232.1 - 0.0027 18.0 0.0 0.018 15.4 0.0 2.1 2 0 0 2 2 2 1 HEAT repeats SUKH_6 PF14568.6 ACT04232.1 - 0.059 13.8 0.1 0.14 12.6 0.1 1.8 1 1 0 1 1 1 0 SMI1-KNR4 cell-wall RCC1_2 PF13540.6 ACT04233.1 - 6.5e-49 162.8 35.0 2.9e-08 33.3 1.4 7.8 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ACT04233.1 - 3.6e-05 24.3 37.8 13 6.5 1.0 12.7 9 5 5 14 14 14 1 Regulator of chromosome condensation (RCC1) repeat RTBV_P12 PF06361.11 ACT04233.1 - 0.0015 18.9 4.9 44 4.5 0.1 5.6 2 1 4 6 6 6 0 Rice tungro bacilliform virus P12 protein iPGM_N PF06415.13 ACT04233.1 - 0.013 15.0 6.1 28 4.1 0.0 5.4 3 3 3 6 6 6 0 BPG-independent PGAM N-terminus (iPGM_N) tRNA_bind PF01588.20 ACT04233.1 - 0.021 14.9 1.2 3.8 7.7 0.0 3.8 2 2 2 4 4 4 0 Putative tRNA binding domain Succ_CoA_lig PF13607.6 ACT04233.1 - 0.03 14.1 0.7 2.4 7.9 0.0 3.3 2 1 2 4 4 4 0 Succinyl-CoA ligase like flavodoxin domain MbtH PF03621.13 ACT04233.1 - 0.051 13.0 0.0 14 5.2 0.0 3.6 2 1 1 3 3 3 0 MbtH-like protein Lipocalin_3 PF12702.7 ACT04233.1 - 0.33 11.1 2.1 39 4.4 0.0 4.1 6 0 0 6 6 6 0 Lipocalin-like NAD_Gly3P_dh_C PF07479.14 ACT04233.1 - 0.82 10.0 15.4 18 5.6 0.1 5.3 5 1 1 6 6 6 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus MerR_1 PF13411.6 ACT04234.1 - 3.9e-20 71.7 0.1 3.9e-20 71.7 0.1 1.9 3 0 0 3 3 3 1 MerR HTH family regulatory protein MerR PF00376.23 ACT04234.1 - 2.4e-12 46.4 0.6 5e-12 45.4 0.0 1.9 2 0 0 2 2 2 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT04234.1 - 8.1e-08 32.7 0.2 2.8e-07 31.0 0.2 1.9 2 1 0 2 2 2 1 MerR, DNA binding Prefoldin PF02996.17 ACT04234.1 - 0.00021 21.2 0.4 0.00028 20.8 0.4 1.3 1 0 0 1 1 1 1 Prefoldin subunit Atg14 PF10186.9 ACT04234.1 - 0.0026 16.9 0.6 0.0028 16.8 0.6 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 TSKS PF15358.6 ACT04234.1 - 0.023 13.1 0.4 0.026 12.9 0.4 1.0 1 0 0 1 1 1 0 Testis-specific serine kinase substrate Helo_like_N PF17111.5 ACT04234.1 - 0.032 13.6 0.5 0.042 13.2 0.5 1.1 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Nif11 PF07862.11 ACT04234.1 - 0.14 12.5 0.1 0.34 11.3 0.1 1.7 2 0 0 2 2 2 0 Nif11 domain adh_short PF00106.25 ACT04235.1 - 1.3e-39 135.7 0.3 1.6e-39 135.4 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT04235.1 - 2.9e-30 105.6 0.5 3.6e-30 105.2 0.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT04235.1 - 1.6e-10 41.2 0.0 2.8e-10 40.4 0.0 1.4 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 ACT04235.1 - 0.003 16.7 0.0 0.005 16.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 ACT04235.1 - 0.0072 15.8 0.1 0.01 15.3 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family MccV PF17508.2 ACT04235.1 - 0.13 12.8 1.4 1.4 9.5 0.1 2.4 2 1 0 2 2 2 0 Microcin V bacteriocin SIS PF01380.22 ACT04236.1 - 4.3e-56 188.4 1.8 1.2e-30 106.0 0.2 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 ACT04236.1 - 5.8e-21 75.1 0.0 1.1e-20 74.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ACT04236.1 - 3.5e-16 59.2 0.0 6.9e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 ACT04236.1 - 1.9e-05 24.7 0.4 0.00017 21.6 0.1 2.5 3 0 0 3 3 3 1 SIS domain GATase_4 PF13230.6 ACT04236.1 - 0.00041 19.3 0.0 0.00077 18.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II DrsE PF02635.15 ACT04236.1 - 0.16 12.4 0.2 0.93 9.9 0.0 2.4 3 0 0 3 3 3 0 DsrE/DsrF-like family PGM_PMM_I PF02878.16 ACT04237.1 - 6.5e-46 155.5 0.0 1.4e-45 154.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 ACT04237.1 - 5.8e-30 103.8 0.2 1.2e-29 102.7 0.1 1.6 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 ACT04237.1 - 7.8e-18 65.0 0.1 2e-17 63.7 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 ACT04237.1 - 1.4e-16 60.4 1.2 2.6e-16 59.6 0.6 1.8 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RII_binding_1 PF10522.9 ACT04237.1 - 0.013 15.6 0.5 0.036 14.2 0.5 1.8 1 0 0 1 1 1 0 RII binding domain CinA_KH PF18146.1 ACT04237.1 - 0.06 13.5 0.3 2 8.6 0.0 2.4 1 1 1 2 2 2 0 Damage-inducible protein CinA KH domain YbbR PF07949.12 ACT04238.1 - 4.4e-28 97.4 21.7 5.2e-13 49.1 3.7 4.6 4 1 0 4 4 4 4 YbbR-like protein DisA_N PF02457.16 ACT04239.1 - 7.7e-46 154.5 0.5 1.1e-45 154.0 0.5 1.3 1 0 0 1 1 1 1 DisA bacterial checkpoint controller nucleotide-binding DUF1652 PF07865.11 ACT04239.1 - 0.033 14.0 0.4 0.12 12.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1652) zf-HC2 PF13490.6 ACT04240.1 - 1.6e-10 41.0 0.9 3.2e-10 40.1 0.9 1.5 1 0 0 1 1 1 1 Putative zinc-finger Bactofilin PF04519.13 ACT04240.1 - 3.3e-07 30.5 2.2 5e-07 29.9 2.2 1.2 1 0 0 1 1 1 1 Polymer-forming cytoskeletal Sigma70_r2 PF04542.14 ACT04241.1 - 1.2e-23 82.7 0.4 1.8e-23 82.1 0.4 1.3 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT04241.1 - 2.7e-16 59.0 0.0 4.8e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT04241.1 - 1e-11 44.2 0.1 2e-11 43.2 0.1 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACT04241.1 - 3.8e-06 26.9 0.8 5.8e-05 23.0 0.8 2.0 1 1 0 1 1 1 1 ECF sigma factor HTH_16 PF12645.7 ACT04241.1 - 0.00017 21.6 0.3 0.00038 20.4 0.2 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_WhiA PF02650.14 ACT04241.1 - 0.0027 18.0 0.3 0.0093 16.3 0.1 2.0 2 0 0 2 2 2 1 WhiA C-terminal HTH domain Phage_antitermQ PF06530.12 ACT04241.1 - 0.019 14.9 0.1 0.052 13.5 0.1 1.7 2 0 0 2 2 2 0 Phage antitermination protein Q UPF0122 PF04297.14 ACT04241.1 - 0.027 14.7 0.6 0.21 11.8 0.0 2.3 2 1 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like DUF1492 PF07374.11 ACT04241.1 - 0.086 13.0 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) EamA PF00892.20 ACT04242.1 - 2.9e-28 98.7 34.4 1.9e-16 60.5 14.1 2.3 1 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 ACT04242.1 - 0.00021 20.6 10.2 0.16 11.2 0.3 3.0 2 1 1 3 3 3 2 Purine nucleobase transmembrane transport Ureide_permease PF07168.11 ACT04242.1 - 0.0098 14.7 2.8 0.37 9.5 0.1 2.3 2 0 0 2 2 2 2 Ureide permease SLATT_1 PF18181.1 ACT04242.1 - 0.26 11.2 0.2 0.26 11.2 0.2 2.6 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 MerE PF05052.12 ACT04242.1 - 0.46 10.4 5.5 1 9.3 0.8 3.1 1 1 0 2 2 2 0 MerE protein Trypsin_2 PF13365.6 ACT04243.1 - 4e-30 105.7 1.7 7.9e-30 104.7 0.3 1.9 2 0 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.26 ACT04243.1 - 1.6e-16 60.8 0.2 3.1e-16 59.8 0.2 1.5 1 0 0 1 1 1 1 Trypsin Peptidase_S46 PF10459.9 ACT04243.1 - 2e-06 26.8 0.6 0.0012 17.6 0.1 2.2 2 0 0 2 2 2 2 Peptidase S46 Peptidase_S32 PF05579.13 ACT04243.1 - 0.0017 17.6 0.6 0.38 9.9 0.0 2.4 2 0 0 2 2 2 2 Equine arteritis virus serine endopeptidase S32 Peptidase_S29 PF02907.15 ACT04243.1 - 0.026 14.3 0.0 0.068 12.9 0.0 1.7 2 0 0 2 2 2 0 Hepatitis C virus NS3 protease PEPcase PF00311.17 ACT04244.1 - 0 1028.5 0.0 0 1028.1 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.6 ACT04244.1 - 0.00035 19.2 0.0 0.00099 17.7 0.0 1.7 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase zf-C3H2C3 PF17122.5 ACT04244.1 - 0.23 11.6 0.1 0.39 10.8 0.1 1.3 1 0 0 1 1 1 0 Zinc-finger ABC_tran PF00005.27 ACT04245.1 - 4.1e-34 118.0 0.0 6e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04245.1 - 5.7e-10 39.5 0.2 0.00012 22.0 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT04245.1 - 2.4e-09 37.0 0.0 0.00057 19.4 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ACT04245.1 - 2.3e-06 27.6 0.1 0.00022 21.1 0.0 2.1 1 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ACT04245.1 - 3.1e-06 26.8 0.2 7e-06 25.7 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ACT04245.1 - 0.0003 20.6 0.1 0.00056 19.7 0.1 1.5 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 ACT04245.1 - 0.00061 18.7 0.3 0.05 12.4 0.1 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_16 PF13191.6 ACT04245.1 - 0.0012 19.3 0.2 0.0022 18.4 0.2 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ACT04245.1 - 0.0012 19.4 0.1 0.0022 18.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ACT04245.1 - 0.0023 17.3 0.5 0.032 13.6 0.2 2.1 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 ACT04245.1 - 0.0042 16.4 0.1 0.0076 15.6 0.1 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_10 PF12846.7 ACT04245.1 - 0.0089 15.0 0.1 0.48 9.3 0.0 2.1 2 0 0 2 2 2 1 AAA-like domain G-alpha PF00503.20 ACT04245.1 - 0.012 14.8 0.1 0.02 14.1 0.1 1.3 1 0 0 1 1 1 0 G-protein alpha subunit RsgA_GTPase PF03193.16 ACT04245.1 - 0.017 15.0 0.4 0.033 14.1 0.1 1.6 2 0 0 2 2 2 0 RsgA GTPase AAA_25 PF13481.6 ACT04245.1 - 0.022 14.3 0.2 0.084 12.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ACT04245.1 - 0.029 14.6 0.4 0.12 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 ACT04245.1 - 0.031 13.9 0.8 0.049 13.3 0.1 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_5 PF07728.14 ACT04245.1 - 0.033 14.2 0.2 0.63 10.0 0.1 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ACT04245.1 - 0.033 14.3 0.6 0.1 12.8 0.6 1.9 1 1 0 1 1 1 0 AAA domain APS_kinase PF01583.20 ACT04245.1 - 0.056 13.3 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA PF00004.29 ACT04245.1 - 0.066 13.6 0.1 1.8 9.0 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DeoRC PF00455.22 ACT04245.1 - 0.092 12.7 0.3 0.26 11.2 0.1 1.8 2 1 0 2 2 2 0 DeoR C terminal sensor domain AAA_14 PF13173.6 ACT04245.1 - 0.12 12.4 0.1 0.81 9.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ACT04245.1 - 0.15 12.4 0.3 0.28 11.5 0.3 1.5 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ACT04245.1 - 0.16 12.2 0.2 1.7 9.0 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NACHT PF05729.12 ACT04245.1 - 0.22 11.4 0.6 0.9 9.4 0.2 1.9 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.6 ACT04245.1 - 0.24 11.1 1.6 0.79 9.4 0.1 2.3 3 0 0 3 3 2 0 AAA domain Nitroreductase PF00881.24 ACT04246.1 - 6.1e-22 78.5 1.0 7.5e-21 74.9 1.0 2.1 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 ACT04246.1 - 0.0058 16.2 0.0 0.017 14.7 0.1 1.7 2 0 0 2 2 2 1 Putative TM nitroreductase SpoIIM PF01944.17 ACT04248.1 - 6.2e-30 104.3 17.9 7.9e-30 104.0 17.9 1.1 1 0 0 1 1 1 1 Stage II sporulation protein M AgrB PF04647.15 ACT04248.1 - 0.011 15.1 2.0 0.011 15.1 2.0 2.4 2 1 0 2 2 2 0 Accessory gene regulator B Polysacc_deac_1 PF01522.21 ACT04249.1 - 8.4e-31 106.5 0.0 1.5e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ACT04249.1 - 2.4e-05 23.7 0.0 0.0072 15.6 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 57 MMM1 PF10296.9 ACT04249.1 - 0.006 15.7 0.1 0.0074 15.4 0.1 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Resolvase PF00239.21 ACT04249.1 - 0.011 15.8 0.1 0.018 15.1 0.1 1.3 1 0 0 1 1 1 0 Resolvase, N terminal domain DUF2334 PF10096.9 ACT04249.1 - 0.012 15.3 0.0 0.62 9.7 0.0 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2334) Polysacc_deac_2 PF04748.13 ACT04249.1 - 0.077 12.2 0.0 0.16 11.1 0.0 1.5 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase LacI PF00356.21 ACT04249.1 - 0.089 12.6 0.4 3.2 7.6 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family KbaA PF14089.6 ACT04250.1 - 3.2e-60 203.1 17.9 3.6e-60 202.9 17.9 1.0 1 0 0 1 1 1 1 KinB-signalling pathway activation in sporulation DUF3377 PF11857.8 ACT04250.1 - 0.041 13.8 0.4 0.41 10.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) YwiC PF14256.6 ACT04250.1 - 0.068 13.5 16.5 1.4 9.2 0.9 2.3 1 1 1 2 2 2 0 YwiC-like protein CcmH PF03918.14 ACT04250.1 - 0.24 10.7 1.6 0.42 9.9 0.5 1.8 1 1 1 2 2 2 0 Cytochrome C biogenesis protein YesK PF14150.6 ACT04250.1 - 1.1 9.6 10.1 0.58 10.4 0.2 3.1 3 0 0 3 3 3 0 YesK-like protein DUF4131 PF13567.6 ACT04250.1 - 1.4 8.6 10.4 0.054 13.1 1.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) GerD PF17898.1 ACT04251.1 - 2.1e-37 127.6 19.8 2.1e-37 127.6 12.8 2.1 2 0 0 2 2 2 2 Spore germination GerD central core domain RPN13_C PF16550.5 ACT04251.1 - 0.099 12.8 2.5 0.62 10.3 0.7 2.5 1 1 0 2 2 2 0 UCH-binding domain DUF5126 PF17166.4 ACT04251.1 - 0.1 12.5 2.6 1.2 9.1 0.0 2.6 3 1 0 3 3 3 0 Domain of unknown function (DUF5126) SurA_N_2 PF13623.6 ACT04251.1 - 1.3 8.9 7.4 11 5.8 2.5 2.2 2 0 0 2 2 2 0 SurA N-terminal domain ParA PF10609.9 ACT04252.1 - 3.6e-88 295.2 0.0 4.7e-88 294.8 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ACT04252.1 - 1.3e-13 51.1 0.0 2.4e-13 50.3 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ACT04252.1 - 1e-11 45.1 1.6 4.7e-10 39.7 0.8 2.6 2 1 0 3 3 3 1 AAA domain MipZ PF09140.11 ACT04252.1 - 9.4e-09 34.9 0.0 1.4e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 ACT04252.1 - 3.2e-06 26.8 0.2 1.7e-05 24.4 0.0 2.1 2 1 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 ACT04252.1 - 4.6e-06 26.0 0.1 9.1e-06 25.1 0.1 1.5 1 0 0 1 1 1 1 Anion-transporting ATPase CBP_BcsQ PF06564.12 ACT04252.1 - 3.4e-05 23.4 0.0 0.0057 16.2 0.1 2.3 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ VirC1 PF07015.11 ACT04252.1 - 0.00015 21.1 0.1 0.00025 20.4 0.1 1.3 1 0 0 1 1 1 1 VirC1 protein MeaB PF03308.16 ACT04252.1 - 0.00034 19.7 0.3 0.00067 18.7 0.3 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 ACT04252.1 - 0.0022 17.8 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_25 PF13481.6 ACT04252.1 - 0.0025 17.4 0.6 0.0048 16.5 0.6 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 ACT04252.1 - 0.024 14.3 0.1 0.04 13.5 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain APS_kinase PF01583.20 ACT04252.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Lipoprotein_16 PF03923.13 ACT04252.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized lipoprotein KTI12 PF08433.10 ACT04252.1 - 0.18 11.2 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Ribosomal_60s PF00428.19 ACT04252.1 - 2.7 8.7 6.3 1 10.0 2.3 2.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Amidase_3 PF01520.18 ACT04253.1 - 1.1e-43 149.3 0.0 1.4e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase PAPS_reduct PF01507.19 ACT04254.1 - 3.4e-49 167.2 0.0 4.2e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Ribosomal_S9 PF00380.19 ACT04255.1 - 6.6e-47 159.0 0.1 7.5e-47 158.8 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13 PF00572.18 ACT04256.1 - 2e-54 183.1 0.4 2.3e-54 182.9 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 PseudoU_synth_1 PF01416.20 ACT04257.1 - 3.3e-42 143.3 0.0 4.2e-28 97.9 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.9 ACT04257.1 - 0.0029 17.5 0.0 0.0041 17.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2344) Ribosomal_L17 PF01196.19 ACT04258.1 - 1.2e-39 135.1 0.4 1.4e-39 134.9 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L17 Bac_DnaA_C PF08299.11 ACT04258.1 - 0.053 13.6 0.2 0.079 13.0 0.2 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein helix-turn-helix XOO_2897-deam PF14440.6 ACT04258.1 - 0.14 12.3 0.3 0.25 11.5 0.1 1.5 2 0 0 2 2 2 0 Xanthomonas XOO_2897-like deaminase RNA_pol_A_CTD PF03118.15 ACT04259.1 - 9.6e-30 102.1 6.6 2.3e-29 100.9 6.6 1.7 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain RNA_pol_L PF01193.24 ACT04259.1 - 4.8e-26 90.0 0.0 1.1e-25 88.8 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.26 ACT04259.1 - 9.5e-26 90.4 0.3 2.5e-25 89.0 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain PASTA PF03793.19 ACT04259.1 - 0.0027 17.5 0.2 1.6 8.7 0.0 2.8 2 0 0 2 2 2 2 PASTA domain HHH_5 PF14520.6 ACT04259.1 - 0.0073 16.9 0.2 0.047 14.3 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix domain Ribosomal_S11 PF00411.19 ACT04260.1 - 2e-52 176.2 1.2 2.4e-52 176.0 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 LPD7 PF18821.1 ACT04260.1 - 0.025 14.7 1.6 0.12 12.5 0.6 2.1 1 1 1 2 2 2 0 Large polyvalent protein-associated domain 7 YdjC PF04794.12 ACT04260.1 - 0.093 12.7 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 YdjC-like protein DUF2188 PF09954.9 ACT04260.1 - 0.39 10.9 2.3 0.27 11.4 0.5 1.7 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) Ribosomal_S13 PF00416.22 ACT04261.1 - 5.4e-37 127.1 5.3 2.3e-35 121.8 5.3 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 ACT04261.1 - 0.0016 17.3 0.0 0.0017 17.2 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF4431 PF14485.6 ACT04261.1 - 0.064 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4431) Ribosomal_L36 PF00444.18 ACT04262.1 - 2.6e-19 69.1 10.2 2.8e-19 69.0 10.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L36 eIF-1a PF01176.19 ACT04263.1 - 3.2e-27 94.1 0.0 3.5e-27 94.0 0.0 1.0 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 RsgA_N PF16745.5 ACT04263.1 - 0.0025 17.5 0.0 0.0034 17.1 0.0 1.2 1 0 0 1 1 1 1 RsgA N-terminal domain KOW PF00467.29 ACT04264.1 - 7.3e-05 22.6 0.9 0.00016 21.5 0.9 1.6 1 0 0 1 1 1 1 KOW motif Multi_ubiq PF14452.6 ACT04264.1 - 0.0026 18.0 0.2 0.0037 17.5 0.2 1.2 1 0 0 1 1 1 1 Multiubiquitin Peptidase_M24 PF00557.24 ACT04265.1 - 1.1e-58 198.4 0.0 1.2e-58 198.2 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 ADK PF00406.22 ACT04266.1 - 1.1e-55 187.9 0.0 1.3e-55 187.6 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ACT04266.1 - 5e-26 91.7 0.0 8.2e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 ACT04266.1 - 3.1e-20 71.9 1.5 5.6e-20 71.0 1.5 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 ACT04266.1 - 1.6e-05 25.1 0.0 2.5e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain TF_Zn_Ribbon PF08271.12 ACT04266.1 - 0.0003 20.2 1.1 0.00057 19.3 1.1 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding AAA_18 PF13238.6 ACT04266.1 - 0.00041 20.9 0.0 0.00083 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 ACT04266.1 - 0.011 16.0 0.0 0.27 11.5 0.0 2.2 1 1 1 2 2 2 0 Hydin Adenylate kinase-like domain AAA PF00004.29 ACT04266.1 - 0.023 15.1 0.0 0.042 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zn-ribbon_8 PF09723.10 ACT04266.1 - 0.028 14.5 0.8 0.058 13.5 0.8 1.5 1 0 0 1 1 1 0 Zinc ribbon domain DUF3039 PF11238.8 ACT04266.1 - 0.035 13.9 0.6 0.074 12.8 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3039) DZR PF12773.7 ACT04266.1 - 0.049 13.7 0.5 0.089 12.8 0.5 1.4 1 0 0 1 1 1 0 Double zinc ribbon DUF1451 PF07295.11 ACT04266.1 - 0.063 13.3 0.1 0.095 12.7 0.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon containing domain AAA_28 PF13521.6 ACT04266.1 - 0.07 13.4 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ACT04266.1 - 0.073 12.4 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Cytidylate_kin PF02224.18 ACT04266.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.4 1 1 0 1 1 1 0 Cytidylate kinase zf_C2H2_13 PF18508.1 ACT04266.1 - 0.27 10.8 1.1 10 5.8 0.1 2.8 3 0 0 3 3 3 0 Zinc finger domain zf-RRN7 PF11781.8 ACT04266.1 - 0.36 10.6 5.2 6.6 6.5 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Zn_ribbon_recom PF13408.6 ACT04266.1 - 0.77 10.3 3.9 5.6 7.6 0.5 2.3 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain Nudix_N_2 PF14803.6 ACT04266.1 - 1.2 9.1 3.8 26 4.9 0.2 2.6 2 0 0 2 2 2 0 Nudix N-terminal Rubredoxin_2 PF18073.1 ACT04266.1 - 3.1 7.6 4.6 41 4.0 4.7 2.1 1 1 1 2 2 2 0 Rubredoxin metal binding domain SecY PF00344.20 ACT04267.1 - 1.1e-113 379.5 23.8 1.4e-113 379.2 23.8 1.1 1 0 0 1 1 1 1 SecY translocase GPHR_N PF12537.8 ACT04267.1 - 0.15 12.2 1.6 26 5.0 0.8 2.7 2 0 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal NADH-u_ox-rdase PF10785.9 ACT04267.1 - 0.17 12.6 0.9 0.73 10.6 0.1 2.5 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit YtpI PF14007.6 ACT04267.1 - 1.4 9.1 8.8 0.21 11.7 0.8 3.6 3 1 1 4 4 4 0 YtpI-like protein Ribosomal_L27A PF00828.19 ACT04268.1 - 1.1e-39 136.0 3.6 1.4e-39 135.7 3.6 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_L30 PF00327.20 ACT04269.1 - 3.1e-20 71.8 0.2 3.5e-20 71.6 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_S5 PF00333.20 ACT04270.1 - 3.7e-32 110.1 2.2 6e-32 109.4 2.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ACT04270.1 - 7e-31 105.5 0.1 1e-30 105.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_L18p PF00861.22 ACT04271.1 - 3.1e-49 166.2 2.7 3.5e-49 166.0 2.7 1.0 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast DUF1308 PF07000.11 ACT04271.1 - 0.12 12.3 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) Ribosomal_L6 PF00347.23 ACT04272.1 - 5.7e-42 142.3 9.4 6e-22 78.1 1.5 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_S8 PF00410.19 ACT04273.1 - 3e-55 185.6 0.2 3.3e-55 185.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S8 Arabinose_Isome PF02610.15 ACT04273.1 - 0.087 12.0 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 L-arabinose isomerase Ribosomal_S14 PF00253.21 ACT04274.1 - 1.5e-24 85.5 3.0 1.7e-24 85.3 3.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e zf_C2H2_13 PF18508.1 ACT04274.1 - 6 6.6 5.9 1.6 8.4 0.6 2.0 1 1 1 2 2 2 0 Zinc finger domain Ribosomal_L5_C PF00673.21 ACT04275.1 - 1.9e-42 143.3 0.1 5e-42 142.0 0.0 1.6 2 0 0 2 2 2 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ACT04275.1 - 2.4e-29 101.4 1.4 4.4e-29 100.6 1.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 DUF2660 PF10859.8 ACT04275.1 - 0.014 15.8 0.0 0.031 14.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2660) ribosomal_L24 PF17136.4 ACT04276.1 - 1.1e-29 102.6 2.4 1.1e-29 102.6 2.4 1.9 2 0 0 2 2 2 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 ACT04276.1 - 8e-08 32.0 1.0 8e-08 32.0 1.0 2.3 2 0 0 2 2 2 1 KOW motif DUF3320 PF11784.8 ACT04276.1 - 0.16 12.0 0.1 0.34 10.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3320) Ribosomal_L14 PF00238.19 ACT04277.1 - 5.7e-54 181.4 0.8 6.3e-54 181.3 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Ribosomal_S17 PF00366.20 ACT04278.1 - 7.8e-33 112.4 4.7 9.6e-33 112.1 4.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 LOH1CR12 PF10158.9 ACT04278.1 - 0.02 14.9 0.5 0.022 14.8 0.5 1.1 1 0 0 1 1 1 0 Tumour suppressor protein Ribosomal_L29 PF00831.23 ACT04279.1 - 2e-24 85.3 0.7 2.2e-24 85.2 0.7 1.0 1 0 0 1 1 1 1 Ribosomal L29 protein Ribosomal_L16 PF00252.18 ACT04280.1 - 3.6e-53 179.1 3.0 4e-53 178.9 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e fn3_PAP PF17808.1 ACT04280.1 - 0.16 12.1 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 Fn3-like domain from Purple Acid Phosphatase Ribosomal_S3_C PF00189.20 ACT04281.1 - 6.5e-41 138.7 1.3 1.3e-40 137.8 1.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 ACT04281.1 - 2.5e-21 75.3 4.5 2.5e-21 75.3 4.5 1.6 2 0 0 2 2 2 1 KH domain KH_4 PF13083.6 ACT04281.1 - 8.1e-06 25.6 0.5 1.5e-05 24.7 0.5 1.5 1 0 0 1 1 1 1 KH domain Imm50 PF15594.6 ACT04281.1 - 0.18 12.1 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 50 KH_5 PF13184.6 ACT04281.1 - 0.45 10.6 3.5 1 9.5 0.4 2.5 3 0 0 3 3 3 0 NusA-like KH domain Ribosomal_L22 PF00237.19 ACT04282.1 - 2.8e-35 120.6 0.6 3.2e-35 120.5 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribosomal_S19 PF00203.21 ACT04283.1 - 1.1e-35 121.4 0.5 1.2e-35 121.2 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_L2_C PF03947.18 ACT04284.1 - 1.6e-57 193.1 1.4 1.6e-57 193.1 1.4 1.7 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ACT04284.1 - 1.1e-33 115.0 2.7 2.4e-33 113.9 2.7 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L23 PF00276.20 ACT04285.1 - 2.2e-33 114.4 1.7 2.4e-33 114.3 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L23 Ribosomal_L4 PF00573.22 ACT04286.1 - 7.6e-74 247.6 0.3 8.6e-74 247.4 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family DHHA1 PF02272.19 ACT04286.1 - 0.065 13.7 0.7 0.12 12.8 0.7 1.4 1 0 0 1 1 1 0 DHHA1 domain Ribosomal_L3 PF00297.22 ACT04287.1 - 4.7e-19 68.6 5.2 8.7e-16 57.9 0.6 2.6 2 1 1 3 3 3 2 Ribosomal protein L3 Ribosomal_S10 PF00338.22 ACT04288.1 - 1.8e-36 124.3 0.1 2.1e-36 124.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e ABC_tran PF00005.27 ACT04289.1 - 1.1e-27 97.2 0.0 2.1e-27 96.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04289.1 - 7.3e-09 35.9 0.8 0.0023 17.8 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT04289.1 - 9e-09 35.1 0.5 4e-08 33.0 0.5 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT04289.1 - 9.9e-05 22.0 0.4 0.00023 20.8 0.1 1.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT04289.1 - 0.00026 20.9 0.2 0.00065 19.6 0.1 1.7 2 0 0 2 2 2 1 RsgA GTPase ABC_ATPase PF09818.9 ACT04289.1 - 0.0084 15.0 1.6 0.43 9.3 0.1 2.4 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA_23 PF13476.6 ACT04289.1 - 0.015 15.8 0.7 0.022 15.3 0.7 1.7 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ACT04289.1 - 0.017 15.4 1.1 0.93 9.8 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 ACT04289.1 - 0.024 14.6 0.8 0.68 9.9 0.2 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_15 PF13175.6 ACT04289.1 - 0.027 14.2 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 ACT04289.1 - 0.031 13.5 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin SbcCD_C PF13558.6 ACT04289.1 - 0.033 14.4 0.1 0.52 10.6 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Mg_chelatase PF01078.21 ACT04289.1 - 0.037 13.4 0.0 0.074 12.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MMR_HSR1 PF01926.23 ACT04289.1 - 0.04 14.0 0.5 0.094 12.8 0.1 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase MukB PF04310.12 ACT04289.1 - 0.055 13.3 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 MukB N-terminal AAA_30 PF13604.6 ACT04289.1 - 0.074 12.8 0.1 0.13 11.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 ACT04289.1 - 0.098 12.7 0.2 0.22 11.5 0.2 1.6 1 0 0 1 1 1 0 Dynamin family Ploopntkinase3 PF18751.1 ACT04289.1 - 0.17 11.8 0.8 1.7 8.5 0.1 2.5 2 1 0 3 3 3 0 P-loop Nucleotide Kinase3 AAA_13 PF13166.6 ACT04289.1 - 0.22 10.1 0.0 0.34 9.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain BPD_transp_2 PF02653.16 ACT04290.1 - 2.5e-30 105.5 34.2 3.7e-30 105.0 34.2 1.1 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component ApeA_NTD1 PF18862.1 ACT04290.1 - 0.19 11.3 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 ApeA N-terminal domain 1 ABC_sub_bind PF04392.12 ACT04291.1 - 5e-84 282.0 8.6 6.2e-84 281.7 8.6 1.0 1 0 0 1 1 1 1 ABC transporter substrate binding protein GTP_EFTU PF00009.27 ACT04292.1 - 4.4e-59 199.3 0.0 7.6e-59 198.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ACT04292.1 - 1.6e-33 115.4 0.1 1.6e-33 115.4 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ACT04292.1 - 1e-16 61.0 4.6 1.2e-16 60.8 3.5 1.7 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ACT04292.1 - 2.4e-05 24.4 0.0 4.9e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 ACT04292.1 - 0.0086 15.7 0.0 0.032 13.8 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 ACT04292.1 - 0.049 13.5 0.0 0.15 12.0 0.0 1.7 1 1 1 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 ACT04293.1 - 5.1e-67 225.2 0.2 8.5e-67 224.5 0.2 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ACT04293.1 - 8.1e-45 151.5 0.1 2e-44 150.3 0.1 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 ACT04293.1 - 7.3e-35 118.9 0.2 1.6e-34 117.8 0.2 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 ACT04293.1 - 1.8e-33 114.4 0.9 3.7e-33 113.4 0.2 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ACT04293.1 - 1.4e-16 60.6 0.2 4.8e-16 58.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 ACT04293.1 - 4.3e-06 26.6 0.0 9.5e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 ACT04293.1 - 0.00063 19.8 0.0 0.0016 18.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 ACT04293.1 - 0.0014 18.0 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 AIG1 family Ribosomal_S7 PF00177.21 ACT04294.1 - 1e-66 223.2 0.3 1.1e-66 223.1 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF3646 PF12362.8 ACT04294.1 - 0.097 13.0 0.1 0.25 11.7 0.1 1.9 1 1 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal Ribosom_S12_S23 PF00164.25 ACT04295.1 - 4.2e-38 129.5 1.5 7.3e-38 128.7 1.5 1.5 1 1 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_L7Ae PF01248.26 ACT04296.1 - 1.3e-11 44.1 0.1 1.3e-11 44.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Chal_sti_synt_N PF00195.19 ACT04296.1 - 0.12 11.8 0.0 0.12 11.8 0.0 1.0 1 0 0 1 1 1 0 Chalcone and stilbene synthases, N-terminal domain Nup96 PF12110.8 ACT04296.1 - 0.17 11.0 0.1 0.2 10.8 0.1 1.1 1 0 0 1 1 1 0 Nuclear protein 96 RNA_pol_Rpb1_1 PF04997.12 ACT04297.1 - 4.9e-90 302.0 0.0 9.7e-90 301.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 ACT04297.1 - 1.4e-72 244.3 0.7 7.7e-71 238.6 0.7 2.3 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 ACT04297.1 - 6.6e-40 137.0 0.0 1.4e-28 100.2 0.0 2.7 1 1 1 2 2 2 2 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 ACT04297.1 - 2.7e-34 118.4 0.4 6.8e-34 117.1 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 ACT04297.1 - 4.2e-12 46.0 0.4 1.2e-11 44.5 0.4 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Apocytochr_F_C PF01333.19 ACT04297.1 - 0.079 13.0 0.2 0.25 11.4 0.2 1.8 1 0 0 1 1 1 0 Apocytochrome F, C-terminal SLH PF00395.20 ACT04297.1 - 0.093 12.8 0.0 0.62 10.1 0.0 2.4 2 0 0 2 2 2 0 S-layer homology domain Peptidase_M23 PF01551.22 ACT04297.1 - 0.12 12.7 0.9 0.82 9.9 0.0 2.7 3 0 0 3 3 3 0 Peptidase family M23 RNA_pol_Rpb2_6 PF00562.28 ACT04298.1 - 1.3e-165 551.3 0.1 3.5e-165 549.8 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_2 PF04561.14 ACT04298.1 - 4.8e-40 137.2 0.3 9.4e-30 103.7 0.0 2.4 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_1 PF04563.15 ACT04298.1 - 5.9e-32 110.8 0.0 2.2e-31 108.9 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 ACT04298.1 - 3.4e-31 107.2 0.0 7.1e-31 106.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 ACT04298.1 - 1.4e-27 95.9 0.0 2.8e-27 94.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_45 PF10385.9 ACT04298.1 - 2e-25 88.8 1.5 3.5e-24 84.8 2.0 2.9 2 0 0 2 2 2 1 RNA polymerase beta subunit external 1 domain MTS PF05175.14 ACT04299.1 - 2.8e-53 179.9 0.0 3.3e-53 179.7 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ACT04299.1 - 2.1e-19 69.8 0.0 2.9e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT04299.1 - 1.2e-14 54.8 0.0 2.1e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ACT04299.1 - 4.9e-14 52.4 0.0 6.1e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ACT04299.1 - 1.9e-10 41.2 0.0 3.7e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT04299.1 - 6.3e-09 36.5 0.0 9e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ACT04299.1 - 3.4e-08 33.5 0.1 4.4e-08 33.1 0.1 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 ACT04299.1 - 3.7e-08 33.0 0.0 4.8e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Met_10 PF02475.16 ACT04299.1 - 8.9e-08 32.1 0.0 1.4e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein GidB PF02527.15 ACT04299.1 - 1.1e-07 31.3 0.0 1.4e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 ACT04299.1 - 1.1e-07 31.8 0.0 1.5e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ACT04299.1 - 1.1e-06 28.1 0.0 1.4e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Cons_hypoth95 PF03602.15 ACT04299.1 - 2.7e-06 27.1 0.0 3.5e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_18 PF12847.7 ACT04299.1 - 5.1e-06 26.5 0.0 6.6e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 ACT04299.1 - 1.6e-05 24.4 0.0 3.3e-05 23.4 0.0 1.4 2 0 0 2 2 2 1 Tellurite resistance protein TehB NodS PF05401.11 ACT04299.1 - 1.7e-05 24.5 0.0 2.2e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_4 PF02390.17 ACT04299.1 - 2.2e-05 24.0 0.0 3.3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_16 PF10294.9 ACT04299.1 - 2.6e-05 24.0 0.1 4e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase RrnaAD PF00398.20 ACT04299.1 - 5.7e-05 22.3 0.0 8e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_15 PF09445.10 ACT04299.1 - 0.00014 21.5 0.0 0.00021 20.9 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.18 ACT04299.1 - 0.00023 20.9 0.0 0.00032 20.4 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 TRM PF02005.16 ACT04299.1 - 0.00038 19.7 0.0 0.0005 19.3 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_3 PF01596.17 ACT04299.1 - 0.00098 18.4 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase DUF43 PF01861.16 ACT04299.1 - 0.0025 17.1 0.0 0.0032 16.7 0.0 1.1 1 0 0 1 1 1 1 Branched-chain polyamine synthase A C-terminal domain TrkA_N PF02254.18 ACT04299.1 - 0.0047 17.2 0.0 0.0087 16.3 0.0 1.6 1 1 0 1 1 1 1 TrkA-N domain FmrO PF07091.11 ACT04299.1 - 0.0054 16.3 0.1 0.0077 15.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_2 PF00891.18 ACT04299.1 - 0.0062 15.9 0.0 0.0077 15.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltr_RsmB-F PF01189.17 ACT04299.1 - 0.0086 15.7 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_32 PF13679.6 ACT04299.1 - 0.032 14.2 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.16 ACT04299.1 - 0.074 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase MetW PF07021.12 ACT04299.1 - 0.098 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW GCD14 PF08704.10 ACT04299.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Ribosomal_L12 PF00542.19 ACT04300.1 - 1.7e-31 108.4 10.8 1.7e-31 108.4 10.8 2.2 2 1 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 ACT04300.1 - 3.5e-22 77.8 10.5 7.2e-20 70.4 8.1 2.5 2 0 0 2 2 2 2 Ribosomal protein L7/L12 dimerisation domain PDH PF02153.17 ACT04300.1 - 0.038 13.0 1.4 0.048 12.7 1.2 1.2 1 1 0 1 1 1 0 Prephenate dehydrogenase CSM2 PF16834.5 ACT04300.1 - 0.053 13.1 0.2 0.1 12.2 0.1 1.6 1 1 1 2 2 2 0 Shu complex component Csm2, DNA-binding DUF2482 PF10655.9 ACT04300.1 - 0.52 10.9 3.6 5.1 7.7 0.1 2.3 1 1 1 2 2 2 0 Hypothetical protein of unknown function (DUF2482) Ribosomal_L10 PF00466.20 ACT04301.1 - 2.9e-28 98.0 0.8 4e-28 97.5 0.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 L27_2 PF09045.10 ACT04301.1 - 0.036 14.0 3.4 0.6 10.1 0.1 3.0 3 1 0 3 3 3 0 L27_2 Ribosomal_L1 PF00687.21 ACT04302.1 - 7.4e-58 195.6 0.0 9.3e-58 195.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Ribosomal_L11_N PF03946.14 ACT04303.1 - 4.7e-34 116.0 0.9 8.5e-34 115.2 0.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 ACT04303.1 - 1.1e-25 89.9 2.2 1.8e-25 89.2 2.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain NusG PF02357.19 ACT04304.1 - 2.4e-28 98.5 0.2 4.2e-28 97.7 0.2 1.4 1 0 0 1 1 1 1 Transcription termination factor nusG KOW PF00467.29 ACT04304.1 - 0.00011 22.0 0.5 0.00011 22.0 0.5 2.4 2 0 0 2 2 2 1 KOW motif B5 PF03484.15 ACT04304.1 - 0.0083 16.4 0.5 0.14 12.5 0.5 2.2 1 1 0 1 1 1 1 tRNA synthetase B5 domain SecE PF00584.20 ACT04305.1 - 3e-21 75.1 2.6 3.8e-21 74.7 2.6 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Ribosomal_L33 PF00471.20 ACT04306.1 - 5.7e-21 74.7 6.3 6.1e-21 74.6 6.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L33 Sigma70_r2 PF04542.14 ACT04307.1 - 2.1e-13 49.9 0.2 4.7e-13 48.7 0.1 1.7 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT04307.1 - 1.2e-09 37.7 0.2 2e-09 36.9 0.2 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 GerE PF00196.19 ACT04307.1 - 6.4e-05 22.4 0.0 0.0001 21.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_16 PF12645.7 ACT04307.1 - 0.0002 21.3 0.2 0.00063 19.7 0.2 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_ECF PF07638.11 ACT04307.1 - 0.0029 17.5 0.4 0.013 15.4 0.4 1.8 1 1 0 1 1 1 1 ECF sigma factor HTH_23 PF13384.6 ACT04307.1 - 0.0088 15.8 0.1 0.019 14.7 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.6 ACT04307.1 - 0.018 14.8 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.6 ACT04307.1 - 0.16 12.0 0.1 0.33 11.0 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn helix NYN_YacP PF05991.11 ACT04308.1 - 2.2e-52 177.4 0.0 2.4e-52 177.2 0.0 1.0 1 0 0 1 1 1 1 YacP-like NYN domain SpoU_methylase PF00588.19 ACT04309.1 - 8.5e-41 139.4 0.0 1.5e-40 138.7 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 ACT04309.1 - 1.5e-23 82.8 0.2 3.5e-23 81.7 0.2 1.7 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding TSNR_N PF04705.12 ACT04309.1 - 0.0035 17.4 0.3 0.009 16.1 0.1 1.8 2 0 0 2 2 2 1 Thiostrepton-resistance methylase, N terminus Ribonuclease_3 PF00636.26 ACT04310.1 - 1e-17 64.7 0.0 1.3e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 ACT04310.1 - 0.022 14.9 0.1 0.051 13.7 0.1 1.7 1 1 0 1 1 1 0 Ribonuclease-III-like tRNA-synt_1e PF01406.19 ACT04311.1 - 1.6e-134 448.0 0.0 2.4e-134 447.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 ACT04311.1 - 6.6e-17 61.3 0.4 7.2e-09 34.9 0.1 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 ACT04311.1 - 5.1e-16 58.9 1.0 1.4e-15 57.5 1.0 1.8 1 0 0 1 1 1 1 DALR domain tRNA-synt_1f PF01921.18 ACT04311.1 - 2.7e-09 36.4 0.0 0.00022 20.3 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (K) tRNA-synt_1 PF00133.22 ACT04311.1 - 1.1e-05 23.9 0.0 0.0025 16.1 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Hexapep PF00132.24 ACT04312.1 - 6.9e-15 54.1 10.7 7.1e-08 31.9 3.2 3.3 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) SATase_N PF06426.14 ACT04312.1 - 0.00016 22.0 0.0 0.00035 20.9 0.0 1.6 2 0 0 2 2 2 1 Serine acetyltransferase, N-terminal Hexapep_2 PF14602.6 ACT04312.1 - 0.0012 18.5 15.0 0.0023 17.6 6.2 3.9 2 2 1 3 3 3 3 Hexapeptide repeat of succinyl-transferase YgbB PF02542.16 ACT04313.1 - 4.1e-66 222.0 0.0 4.8e-66 221.8 0.0 1.0 1 0 0 1 1 1 1 YgbB family IspD PF01128.19 ACT04314.1 - 7.2e-74 248.3 0.9 8.9e-74 247.9 0.9 1.0 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NTP_transf_3 PF12804.7 ACT04314.1 - 6.3e-17 62.4 2.2 8.1e-17 62.0 2.2 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.19 ACT04314.1 - 0.025 14.5 0.0 0.032 14.1 0.0 1.1 1 0 0 1 1 1 0 Cytidylyltransferase PIN_9 PF18477.1 ACT04315.1 - 2.9e-06 27.6 0.1 6.5e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 PIN like domain TRAM PF01938.20 ACT04315.1 - 6.3e-05 22.9 0.7 0.00017 21.5 0.7 1.8 1 0 0 1 1 1 1 TRAM domain PIN PF01850.21 ACT04315.1 - 7.4e-05 23.2 0.2 0.00013 22.4 0.2 1.4 1 0 0 1 1 1 1 PIN domain PIN_4 PF13638.6 ACT04315.1 - 0.001 19.3 0.4 0.0016 18.7 0.4 1.3 1 0 0 1 1 1 1 PIN domain PIN_5 PF08745.11 ACT04315.1 - 0.0039 16.7 0.5 0.022 14.2 0.1 2.1 2 1 0 2 2 2 1 PINc domain ribonuclease Yip1 PF04893.17 ACT04315.1 - 0.082 12.6 7.9 0.12 12.1 7.9 1.2 1 0 0 1 1 1 0 Yip1 domain MORN PF02493.20 ACT04315.1 - 0.54 10.3 1.9 0.68 9.9 0.1 2.1 2 0 0 2 2 2 0 MORN repeat MazG PF03819.17 ACT04316.1 - 0.0063 16.7 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain RPA_interact_C PF14768.6 ACT04316.1 - 0.42 11.2 4.7 0.35 11.5 1.4 2.2 1 1 1 2 2 2 0 Replication protein A interacting C-terminal CDP-OH_P_transf PF01066.21 ACT04317.1 - 2.7e-14 53.7 0.1 2.7e-14 53.7 0.1 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF4267 PF14087.6 ACT04317.1 - 0.0075 16.3 3.0 0.51 10.4 0.3 2.6 3 1 0 3 3 3 2 Domain of unknown function (DUF4267) Barstar PF01337.18 ACT04317.1 - 0.22 11.6 0.0 0.37 10.9 0.0 1.3 1 0 0 1 1 1 0 Barstar (barnase inhibitor) MFS_MOT1 PF16983.5 ACT04317.1 - 1.4 9.4 8.7 0.4 11.1 3.5 2.6 2 1 0 2 2 2 0 Molybdate transporter of MFS superfamily YtpI PF14007.6 ACT04317.1 - 7.6 6.8 12.6 2.5 8.3 1.2 3.3 3 0 0 3 3 3 0 YtpI-like protein DisA-linker PF10635.9 ACT04318.1 - 9.9e-55 184.2 5.4 1.6e-54 183.6 5.4 1.3 1 0 0 1 1 1 1 DisA bacterial checkpoint controller linker region DisA_N PF02457.16 ACT04318.1 - 1.5e-26 92.3 0.0 3.8e-26 91.0 0.0 1.7 1 0 0 1 1 1 1 DisA bacterial checkpoint controller nucleotide-binding HHH_2 PF12826.7 ACT04318.1 - 4.7e-08 33.0 0.2 4.4e-05 23.5 0.0 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH PF00633.23 ACT04318.1 - 8.7e-05 22.2 0.0 0.00026 20.7 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 ACT04318.1 - 0.012 16.2 1.6 0.031 14.9 0.0 2.5 3 0 0 3 3 3 0 Helix-hairpin-helix domain AAA_25 PF13481.6 ACT04319.1 - 1.8e-18 66.9 0.2 5.9e-18 65.1 0.1 1.9 2 1 0 2 2 2 1 AAA domain ATPase PF06745.13 ACT04319.1 - 1.4e-16 60.6 0.0 2.5e-07 30.3 0.0 2.2 2 0 0 2 2 2 2 KaiC Rubredoxin_2 PF18073.1 ACT04319.1 - 2e-13 49.8 4.8 3.1e-13 49.2 4.8 1.3 1 0 0 1 1 1 1 Rubredoxin metal binding domain ChlI PF13541.6 ACT04319.1 - 3.4e-08 33.4 0.0 7.5e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase DnaB_C PF03796.15 ACT04319.1 - 5.1e-06 26.0 0.0 8.4e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 ACT04319.1 - 7.3e-06 26.5 0.0 1.2e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Lon_C PF05362.13 ACT04319.1 - 2.3e-05 24.0 0.0 4.8e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA_22 PF13401.6 ACT04319.1 - 0.00028 21.2 0.0 0.00052 20.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ACT04319.1 - 0.00047 19.9 0.0 0.0034 17.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 ACT04319.1 - 0.001 19.0 0.1 0.0033 17.3 0.0 1.8 1 1 1 2 2 2 1 NTPase RecA PF00154.21 ACT04319.1 - 0.0034 16.9 0.1 0.0053 16.2 0.1 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KdpD PF02702.17 ACT04319.1 - 0.004 16.6 0.0 0.0069 15.9 0.0 1.3 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain Rad51 PF08423.11 ACT04319.1 - 0.0063 15.8 0.3 0.016 14.5 0.3 1.7 1 1 0 1 1 1 1 Rad51 AAA_5 PF07728.14 ACT04319.1 - 0.0094 16.0 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ACT04319.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.12 ACT04319.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain HypA PF01155.19 ACT04319.1 - 0.021 14.9 1.0 0.047 13.7 1.0 1.7 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DAP3 PF10236.9 ACT04319.1 - 0.033 13.4 0.0 0.052 12.7 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 MeaB PF03308.16 ACT04319.1 - 0.038 13.0 0.1 0.19 10.7 0.1 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 ACT04319.1 - 0.045 13.8 0.2 0.098 12.7 0.2 1.8 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 ACT04319.1 - 0.052 13.0 0.0 0.075 12.5 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_14 PF13173.6 ACT04319.1 - 0.059 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ACT04319.1 - 0.066 13.6 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ACT04319.1 - 0.085 12.6 0.1 0.22 11.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ACT04319.1 - 0.094 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) KTI12 PF08433.10 ACT04319.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 zinc_ribbon_6 PF14599.6 ACT04319.1 - 0.13 12.3 0.2 0.25 11.4 0.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon ArsA_ATPase PF02374.15 ACT04319.1 - 0.14 11.3 0.2 0.34 10.1 0.2 1.6 1 0 0 1 1 1 0 Anion-transporting ATPase AAA_31 PF13614.6 ACT04319.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zn_ribbon_SprT PF17283.2 ACT04319.1 - 5.6 7.0 5.0 11 6.0 0.4 2.3 1 1 1 2 2 2 0 SprT-like zinc ribbon domain ABM PF03992.16 ACT04320.1 - 1.8e-17 63.2 0.2 2.3e-17 62.9 0.2 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase AAA_2 PF07724.14 ACT04321.1 - 1.5e-60 204.2 0.3 1e-57 195.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 ACT04321.1 - 9e-38 128.4 2.7 2.4e-37 127.0 2.7 1.7 1 0 0 1 1 1 1 AAA lid domain Clp_N PF02861.20 ACT04321.1 - 4.7e-35 119.5 10.4 1.1e-17 63.9 0.4 3.5 3 0 0 3 3 2 2 Clp amino terminal domain, pathogenicity island component ClpB_D2-small PF10431.9 ACT04321.1 - 1e-26 92.8 1.2 2.9e-26 91.3 0.4 2.3 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 ACT04321.1 - 1.1e-26 93.8 0.1 8.9e-14 52.1 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ACT04321.1 - 4.1e-19 68.9 0.1 1.3e-13 51.1 0.0 3.0 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ACT04321.1 - 1.9e-12 47.9 6.7 6.3e-05 23.4 0.0 4.7 4 2 1 5 5 4 2 AAA ATPase domain Sigma54_activat PF00158.26 ACT04321.1 - 2.1e-12 47.0 0.0 2.9e-07 30.3 0.0 2.6 2 1 0 2 2 2 2 Sigma-54 interaction domain IstB_IS21 PF01695.17 ACT04321.1 - 7.9e-10 38.7 0.1 0.0033 17.2 0.0 3.3 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_22 PF13401.6 ACT04321.1 - 1.9e-08 34.7 5.0 0.027 14.8 0.1 5.6 4 2 0 4 4 3 2 AAA domain AAA_18 PF13238.6 ACT04321.1 - 3.8e-08 34.0 0.4 0.028 15.0 0.0 3.8 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 ACT04321.1 - 1.2e-07 31.8 0.0 0.085 12.9 0.0 3.7 3 0 0 3 3 3 2 AAA domain TniB PF05621.11 ACT04321.1 - 2.1e-07 30.6 0.0 0.00037 20.0 0.0 3.6 2 1 0 2 2 2 1 Bacterial TniB protein RuvB_N PF05496.12 ACT04321.1 - 2.1e-07 30.8 1.5 0.13 11.9 0.0 4.2 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain UVR PF02151.19 ACT04321.1 - 2.8e-07 30.0 8.7 9.6e-07 28.4 8.7 2.0 1 0 0 1 1 1 1 UvrB/uvrC motif Mg_chelatase PF01078.21 ACT04321.1 - 9.6e-06 25.1 0.6 0.93 8.8 0.0 3.7 3 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 ACT04321.1 - 1.3e-05 24.8 0.0 0.036 13.6 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region DNA_pol3_delta2 PF13177.6 ACT04321.1 - 2.2e-05 24.3 0.0 0.0055 16.5 0.0 3.2 2 1 0 2 2 2 1 DNA polymerase III, delta subunit RNA_helicase PF00910.22 ACT04321.1 - 4e-05 23.9 0.0 0.78 10.2 0.0 3.1 3 0 0 3 3 2 2 RNA helicase ATPase_2 PF01637.18 ACT04321.1 - 8.6e-05 22.6 6.0 0.89 9.4 0.1 4.1 3 2 1 4 4 3 2 ATPase domain predominantly from Archaea Roc PF08477.13 ACT04321.1 - 8.8e-05 22.7 0.0 0.36 11.0 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 ACT04321.1 - 0.00012 22.2 1.3 1.1 9.5 0.0 3.9 4 1 0 4 4 4 2 AAA domain Zeta_toxin PF06414.12 ACT04321.1 - 0.00015 21.1 0.2 0.066 12.5 0.0 3.0 3 0 0 3 3 3 1 Zeta toxin RsgA_GTPase PF03193.16 ACT04321.1 - 0.0002 21.3 0.0 0.65 9.9 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_3 PF07726.11 ACT04321.1 - 0.00022 21.1 0.1 0.12 12.3 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ACT04321.1 - 0.00022 21.5 0.0 0.51 10.6 0.0 3.0 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 ACT04321.1 - 0.00029 20.8 0.0 0.97 9.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ACT04321.1 - 0.0003 20.7 0.0 0.29 11.0 0.0 2.7 2 0 0 2 2 2 1 NACHT domain KTI12 PF08433.10 ACT04321.1 - 0.00033 20.2 0.0 3.6 6.9 0.0 3.5 3 0 0 3 3 3 1 Chromatin associated protein KTI12 ResIII PF04851.15 ACT04321.1 - 0.0009 19.3 0.0 1 9.3 0.0 3.8 3 1 0 4 4 3 1 Type III restriction enzyme, res subunit Torsin PF06309.11 ACT04321.1 - 0.0025 17.9 0.0 0.21 11.7 0.0 2.6 2 0 0 2 2 2 1 Torsin AAA_24 PF13479.6 ACT04321.1 - 0.0035 17.1 0.0 3.2 7.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ACT04321.1 - 0.0066 17.0 0.3 1.7 9.2 0.0 3.1 3 0 0 3 3 2 1 ABC transporter AAA_25 PF13481.6 ACT04321.1 - 0.0074 15.9 0.1 6.5 6.3 0.0 3.7 3 0 0 3 3 3 0 AAA domain PhoH PF02562.16 ACT04321.1 - 0.011 15.2 0.1 5.6 6.4 0.0 2.9 3 0 0 3 3 2 0 PhoH-like protein Parvo_NS1 PF01057.17 ACT04321.1 - 0.011 14.8 0.1 21 4.1 0.0 3.3 3 0 0 3 3 3 0 Parvovirus non-structural protein NS1 TIP49 PF06068.13 ACT04321.1 - 0.014 14.6 2.8 1.4 8.1 0.1 3.6 3 1 0 4 4 4 0 TIP49 P-loop domain AAA_30 PF13604.6 ACT04321.1 - 0.015 15.0 0.2 12 5.6 0.0 3.2 2 1 0 2 2 2 0 AAA domain CbiA PF01656.23 ACT04321.1 - 0.026 14.6 0.1 5.9 7.0 0.0 3.6 2 2 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.19 ACT04321.1 - 0.031 13.9 0.0 2.4 7.7 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ACT04321.1 - 0.033 14.3 0.0 12 6.0 0.1 3.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.22 ACT04321.1 - 0.038 13.2 0.0 0.97 8.6 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain AAA_23 PF13476.6 ACT04321.1 - 0.055 14.0 0.1 0.055 14.0 0.1 3.7 2 2 0 2 2 1 0 AAA domain Sigma54_activ_2 PF14532.6 ACT04321.1 - 0.11 12.6 0.0 1.7 8.8 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Ras PF00071.22 ACT04321.1 - 0.12 12.0 0.0 12 5.5 0.0 2.7 3 0 0 3 3 2 0 Ras family FtsH_ext PF06480.15 ACT04321.1 - 0.12 12.7 0.2 24 5.3 0.1 2.6 2 0 0 2 2 2 0 FtsH Extracellular PduV-EutP PF10662.9 ACT04321.1 - 0.16 11.8 0.0 5.5 6.7 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 ACT04321.1 - 0.17 11.7 0.0 18 5.2 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_19 PF13245.6 ACT04321.1 - 0.38 11.1 3.1 7.4 6.9 0.2 4.0 3 2 0 3 3 3 0 AAA domain ATP-gua_Ptrans PF00217.19 ACT04322.1 - 6.9e-73 244.6 0.7 9.7e-73 244.1 0.7 1.2 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain UVR PF02151.19 ACT04323.1 - 2.5e-06 27.0 9.7 3.9e-06 26.4 9.7 1.3 1 0 0 1 1 1 1 UvrB/uvrC motif PhnA_Zn_Ribbon PF08274.12 ACT04323.1 - 0.054 13.5 3.4 41 4.3 0.1 4.0 4 0 0 4 4 4 0 PhnA Zinc-Ribbon HypA PF01155.19 ACT04323.1 - 0.16 12.0 2.7 2 8.5 0.2 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TF_Zn_Ribbon PF08271.12 ACT04323.1 - 0.26 10.8 4.7 0.23 11.0 0.5 2.6 3 0 0 3 3 3 0 TFIIB zinc-binding DNA_RNApol_7kD PF03604.13 ACT04323.1 - 0.27 10.9 0.1 0.27 10.9 0.1 3.2 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 ACT04323.1 - 0.44 10.6 8.5 3.1 7.9 0.7 2.5 2 1 0 2 2 2 0 Double zinc ribbon zf-RING_7 PF02591.15 ACT04323.1 - 0.49 10.6 0.1 0.49 10.6 0.1 3.8 4 0 0 4 4 4 0 C4-type zinc ribbon domain Nudix_N_2 PF14803.6 ACT04323.1 - 2.2 8.3 10.2 0.22 11.4 0.6 3.1 3 0 0 3 3 3 0 Nudix N-terminal Zn_Tnp_IS1595 PF12760.7 ACT04323.1 - 2.6 8.1 10.7 1.1 9.3 3.1 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_15 PF17032.5 ACT04323.1 - 4.2 8.2 8.9 13 6.6 0.9 2.9 2 1 0 2 2 2 0 zinc-ribbon family zf-C2H2_11 PF16622.5 ACT04323.1 - 5.3 6.9 7.4 2.8 7.8 0.2 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-BED PF02892.15 ACT04323.1 - 6.2 6.9 6.6 0.87 9.7 0.4 2.8 3 1 0 3 3 3 0 BED zinc finger zf-CHY PF05495.12 ACT04323.1 - 7.1 7.2 8.8 2.9 8.4 0.8 2.5 2 1 0 2 2 2 0 CHY zinc finger zf-ribbon_3 PF13248.6 ACT04323.1 - 9.6 5.8 8.3 4.9 6.7 0.1 3.2 3 0 0 3 3 3 0 zinc-ribbon domain CtsR PF05848.11 ACT04324.1 - 8.6e-39 131.3 0.2 1.8e-38 130.3 0.2 1.5 1 0 0 1 1 1 1 CtsR N-terminal HTH domain CtsR_C PF17727.1 ACT04324.1 - 6.9e-22 77.4 1.3 6.9e-22 77.4 1.3 1.6 2 0 0 2 2 2 1 CtsR C-terminal dimerization domain DNA_ligase_aden PF01653.18 ACT04325.1 - 1.7e-91 306.7 0.1 2.5e-91 306.1 0.1 1.2 1 0 0 1 1 1 1 NAD-dependent DNA ligase adenylation domain DNA_ligase_OB PF03120.16 ACT04325.1 - 5.3e-23 80.7 0.6 9.9e-23 79.8 0.6 1.5 1 0 0 1 1 1 1 NAD-dependent DNA ligase OB-fold domain HHH_2 PF12826.7 ACT04325.1 - 4.9e-20 71.4 0.0 2.9e-18 65.7 0.1 3.2 3 0 0 3 3 3 1 Helix-hairpin-helix motif BRCT PF00533.26 ACT04325.1 - 1.1e-13 51.3 0.0 3e-13 50.0 0.0 1.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain HHH_5 PF14520.6 ACT04325.1 - 8.4e-08 32.7 0.0 0.002 18.7 0.0 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix domain PTCB-BRCT PF12738.7 ACT04325.1 - 1.9e-07 30.9 0.1 3.9e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain HHH PF00633.23 ACT04325.1 - 0.00026 20.7 0.2 0.002 17.9 0.0 2.7 2 0 0 2 2 2 1 Helix-hairpin-helix motif DNA_ligase_ZBD PF03119.16 ACT04325.1 - 0.0024 17.8 1.5 0.0052 16.8 1.5 1.6 1 0 0 1 1 1 1 NAD-dependent DNA ligase C4 zinc finger domain DUF669 PF05037.13 ACT04325.1 - 0.12 12.5 0.0 0.41 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF669) UvrD-helicase PF00580.21 ACT04326.1 - 1.2e-84 284.5 0.5 1.9e-84 283.9 0.0 1.5 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ACT04326.1 - 3.8e-74 250.2 1.4 1.8e-73 247.9 1.4 2.0 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ACT04326.1 - 7.2e-35 120.5 0.3 2.7e-34 118.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 ACT04326.1 - 5.4e-12 45.4 0.0 1.3e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 ACT04326.1 - 2.2e-07 30.8 0.0 0.00028 20.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 ACT04326.1 - 2.2e-06 27.6 0.1 0.097 12.4 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 ACT04326.1 - 0.004 17.0 0.0 0.0084 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Exonuc_V_gamma PF04257.14 ACT04326.1 - 0.023 13.0 0.1 0.023 13.0 0.1 1.5 2 0 0 2 2 2 0 Exodeoxyribonuclease V, gamma subunit ResIII PF04851.15 ACT04326.1 - 0.12 12.3 2.8 0.31 11.0 0.9 2.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit PcrB PF01884.17 ACT04327.1 - 7.2e-67 225.1 0.1 8.9e-67 224.8 0.1 1.0 1 0 0 1 1 1 1 PcrB family Trp_syntA PF00290.20 ACT04327.1 - 0.00087 18.2 1.8 0.0022 16.9 0.2 2.3 3 1 1 4 4 4 1 Tryptophan synthase alpha chain BtpA PF03437.15 ACT04327.1 - 0.03 13.8 0.3 0.55 9.6 0.1 2.1 2 0 0 2 2 2 0 BtpA family Peptidase_U32 PF01136.19 ACT04328.1 - 2e-101 338.0 0.0 1.6e-84 282.7 0.0 2.6 3 0 0 3 3 3 2 Peptidase family U32 DUF3656 PF12392.8 ACT04328.1 - 6.7e-22 78.2 0.0 1.8e-21 76.8 0.0 1.8 1 0 0 1 1 1 1 Collagenase Integrin_B_tail PF07965.12 ACT04328.1 - 0.44 11.1 2.9 1.7 9.2 0.7 2.2 2 0 0 2 2 2 0 Integrin beta tail domain Cu_amine_oxidN1 PF07833.11 ACT04329.1 - 3.7e-26 91.4 10.1 4.8e-21 75.1 5.6 3.5 2 1 1 3 3 3 2 Copper amine oxidase N-terminal domain DcrB PF08786.11 ACT04329.1 - 0.0019 18.3 0.0 0.0076 16.3 0.0 2.1 2 0 0 2 2 2 1 DcrB P22_AR_N PF10547.9 ACT04329.1 - 0.01 16.2 1.5 0.26 11.6 0.3 2.6 1 1 1 2 2 2 2 P22_AR N-terminal domain Big_3_2 PF12245.8 ACT04329.1 - 0.019 15.2 2.7 5.2 7.4 0.6 3.2 2 1 0 2 2 2 0 Bacterial Ig-like domain Trypsin_2 PF13365.6 ACT04330.1 - 9.8e-30 104.4 0.6 2.4e-29 103.2 0.6 1.7 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 ACT04330.1 - 9.6e-19 68.1 0.2 1.5e-18 67.4 0.2 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 ACT04330.1 - 1.1e-08 35.2 0.1 2.8e-08 34.0 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ACT04330.1 - 1e-05 25.3 0.0 2.7e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 ACT04330.1 - 4.1e-05 23.8 0.0 0.00011 22.4 0.0 1.8 1 0 0 1 1 1 1 PDZ domain Peptidase_S46 PF10459.9 ACT04330.1 - 0.0029 16.3 1.2 0.033 12.9 0.2 2.0 2 0 0 2 2 2 1 Peptidase S46 Tricorn_PDZ PF14685.6 ACT04330.1 - 0.041 13.8 0.1 0.14 12.2 0.1 2.0 2 0 0 2 2 2 0 Tricorn protease PDZ domain DUF31 PF01732.16 ACT04330.1 - 0.089 12.3 1.4 9.1 5.7 0.4 2.1 2 0 0 2 2 2 0 Putative peptidase (DUF31) AP_endonuc_2 PF01261.24 ACT04331.1 - 4.1e-31 108.1 0.0 6.8e-31 107.4 0.0 1.4 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel AP_endonuc_2_N PF07582.12 ACT04331.1 - 1.6e-22 79.0 0.1 3.5e-22 77.9 0.1 1.6 1 0 0 1 1 1 1 AP endonuclease family 2 C terminus DUF1643 PF07799.12 ACT04331.1 - 0.089 13.0 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) Glyco_transf_18 PF15024.6 ACT04331.1 - 0.27 9.8 0.5 3.7 6.0 0.0 2.0 1 1 1 2 2 2 0 Glycosyltransferase family 18 DUF2087 PF09860.9 ACT04332.1 - 1e-21 76.8 0.1 1.8e-21 76.0 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2087) HTH_20 PF12840.7 ACT04332.1 - 1.2e-10 41.3 0.4 1.8e-10 40.7 0.4 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 ACT04332.1 - 7.1e-09 35.4 0.0 1.2e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 ACT04332.1 - 1.5e-06 28.0 0.3 3.1e-06 27.0 0.3 1.5 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT04332.1 - 3e-05 23.5 0.0 5.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 ACT04332.1 - 0.0001 22.1 0.2 0.00023 21.1 0.2 1.6 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 ACT04332.1 - 0.00055 19.8 0.1 0.0015 18.4 0.1 1.7 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 ACT04332.1 - 0.00074 19.4 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_29 PF13551.6 ACT04332.1 - 0.0039 17.2 0.1 0.0069 16.4 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 ACT04332.1 - 0.0073 16.4 0.1 0.014 15.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain Fe_dep_repress PF01325.19 ACT04332.1 - 0.015 15.4 0.1 0.052 13.8 0.0 1.9 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain TFIIE_alpha PF02002.17 ACT04332.1 - 0.016 15.1 0.0 0.047 13.6 0.0 1.8 1 1 0 1 1 1 0 TFIIE alpha subunit TrmB PF01978.19 ACT04332.1 - 0.03 14.2 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB PIN_8 PF18476.1 ACT04332.1 - 0.031 14.2 1.4 0.036 13.9 1.4 1.3 1 0 0 1 1 1 0 PIN like domain Rrf2 PF02082.20 ACT04332.1 - 0.14 12.5 0.1 0.3 11.5 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator DUF2759 PF10958.8 ACT04333.1 - 0.019 14.7 6.7 0.019 14.7 6.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2759) DUF3043 PF11241.8 ACT04333.1 - 0.42 10.6 3.1 0.51 10.4 3.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) UvrA_inter PF17760.1 ACT04334.1 - 5.7e-42 142.2 2.4 4.6e-41 139.3 2.2 2.3 2 0 0 2 2 2 1 UvrA interaction domain UvrA_DNA-bind PF17755.1 ACT04334.1 - 1.6e-36 125.0 0.0 8.5e-34 116.2 0.0 3.4 3 0 0 3 3 3 1 UvrA DNA-binding domain ABC_tran PF00005.27 ACT04334.1 - 2.1e-21 76.9 0.1 4.3e-10 40.2 0.0 4.4 3 1 0 3 3 3 3 ABC transporter SMC_N PF02463.19 ACT04334.1 - 8.7e-12 44.9 0.0 0.0021 17.5 0.0 4.0 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT04334.1 - 5.4e-08 32.5 0.3 0.0031 17.2 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT04334.1 - 2.1e-07 31.5 0.8 0.045 14.1 0.0 3.2 3 1 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 ACT04334.1 - 3e-07 30.6 0.6 0.043 13.6 0.0 4.3 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ACT04334.1 - 6.5e-06 26.1 0.1 0.061 13.2 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 ACT04334.1 - 1.7e-05 25.1 0.9 0.15 12.3 0.0 3.8 4 1 1 5 5 3 2 AAA domain AAA_25 PF13481.6 ACT04334.1 - 2.5e-05 24.0 0.4 0.16 11.5 0.0 3.4 4 0 0 4 4 4 2 AAA domain AAA_23 PF13476.6 ACT04334.1 - 8.4e-05 23.2 5.2 0.38 11.2 0.0 3.7 3 1 0 3 3 3 2 AAA domain AAA_33 PF13671.6 ACT04334.1 - 0.0002 21.6 0.1 1.1 9.5 0.0 3.6 3 0 0 3 3 3 1 AAA domain DnaJ_CXXCXGXG PF00684.19 ACT04334.1 - 0.00024 21.4 1.6 0.2 12.1 0.2 3.5 3 0 0 3 3 3 1 DnaJ central domain APS_kinase PF01583.20 ACT04334.1 - 0.00027 20.8 0.1 1 9.3 0.0 2.8 2 0 0 2 2 2 2 Adenylylsulphate kinase AAA_14 PF13173.6 ACT04334.1 - 0.00031 20.8 0.0 1.1 9.3 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 ACT04334.1 - 0.00043 20.1 0.2 0.022 14.5 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 ACT04334.1 - 0.00065 20.2 0.0 0.94 10.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 ACT04334.1 - 0.00096 18.6 0.5 0.59 9.4 0.1 3.3 4 0 0 4 4 3 1 KaiC cobW PF02492.19 ACT04334.1 - 0.0017 18.0 0.1 0.12 11.9 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 ACT04334.1 - 0.003 17.5 0.0 0.29 11.1 0.0 2.4 2 0 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 ACT04334.1 - 0.0063 16.5 0.0 4.4 7.2 0.0 2.6 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 ACT04334.1 - 0.015 15.4 0.1 0.97 9.5 0.1 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase BCA_ABC_TP_C PF12399.8 ACT04334.1 - 0.023 14.6 0.5 1.6 8.7 0.0 2.8 2 0 0 2 2 2 0 Branched-chain amino acid ATP-binding cassette transporter DUF2075 PF09848.9 ACT04334.1 - 0.026 13.8 0.0 1.6 7.9 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 ACT04334.1 - 0.029 14.1 0.0 0.2 11.4 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 ACT04334.1 - 0.036 13.2 0.1 1.2 8.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_15 PF13175.6 ACT04334.1 - 0.063 13.0 2.5 20 4.8 0.0 4.3 5 0 0 5 5 4 0 AAA ATPase domain AAA_30 PF13604.6 ACT04334.1 - 0.081 12.6 0.2 9.7 5.8 0.1 2.8 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 ACT04334.1 - 0.086 11.8 0.4 1.5 7.7 0.0 2.5 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RACo_linker PF17650.1 ACT04334.1 - 0.094 12.6 0.1 18 5.2 0.0 2.8 2 0 0 2 2 2 0 RACo linker region Zeta_toxin PF06414.12 ACT04334.1 - 0.1 11.9 0.0 17 4.7 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 ACT04334.1 - 0.11 12.1 0.0 21 4.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ACT04334.1 - 0.12 12.8 0.0 6.2 7.3 0.0 2.5 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.17 ACT04334.1 - 0.15 12.1 1.2 0.34 11.0 0.0 2.2 2 0 0 2 2 1 0 Helicase HerA, central domain NTPase_1 PF03266.15 ACT04334.1 - 0.66 9.9 4.7 1.7 8.6 0.1 3.4 3 1 1 4 4 4 0 NTPase UvrB_inter PF17757.1 ACT04335.1 - 1e-33 115.4 1.4 1.8e-33 114.6 0.3 2.1 2 0 0 2 2 1 1 UvrB interaction domain UvrB PF12344.8 ACT04335.1 - 6.5e-24 83.5 1.4 1.3e-23 82.5 1.4 1.6 1 0 0 1 1 1 1 Ultra-violet resistance protein B Helicase_C PF00271.31 ACT04335.1 - 3.4e-19 69.2 1.9 2e-17 63.6 0.1 3.0 1 1 2 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT04335.1 - 4.5e-13 49.5 0.0 9.2e-12 45.3 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UVR PF02151.19 ACT04335.1 - 4.3e-07 29.5 9.3 4.3e-07 29.5 9.3 3.0 2 0 0 2 2 2 1 UvrB/uvrC motif AAA_19 PF13245.6 ACT04335.1 - 0.00047 20.5 1.3 0.44 10.9 0.1 2.8 3 0 0 3 3 3 2 AAA domain UvrD-helicase PF00580.21 ACT04335.1 - 0.00056 19.5 6.6 0.031 13.8 1.9 2.3 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 ACT04335.1 - 0.00078 19.2 0.0 0.13 12.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain DEAD PF00270.29 ACT04335.1 - 0.014 15.2 0.0 0.41 10.4 0.0 3.0 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_22 PF13401.6 ACT04335.1 - 0.023 15.0 1.6 2.5 8.4 0.0 3.3 4 0 0 4 4 4 0 AAA domain AAA_7 PF12775.7 ACT04335.1 - 0.091 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 ACT04335.1 - 0.15 12.5 1.1 8.1 7.0 0.0 2.8 3 0 0 3 3 3 0 ABC transporter DUF4391 PF14335.6 ACT04335.1 - 10 5.8 9.0 0.68 9.6 3.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4391) PDZ_2 PF13180.6 ACT04336.1 - 1.3e-06 28.6 0.0 2.6e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ACT04336.1 - 1.2e-05 25.1 0.0 2.8e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 ACT04336.1 - 0.0079 16.5 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 ACT04336.1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Tricorn protease PDZ domain Peptidase_S41 PF03572.18 ACT04337.1 - 3.3e-48 163.4 0.3 6.3e-48 162.5 0.3 1.5 1 0 0 1 1 1 1 Peptidase family S41 PG_binding_1 PF01471.18 ACT04337.1 - 8.3e-16 57.9 0.9 1.9e-15 56.8 0.3 1.9 2 0 0 2 2 2 1 Putative peptidoglycan binding domain PDZ_6 PF17820.1 ACT04337.1 - 2.2e-13 49.9 1.1 3.5e-13 49.2 0.3 1.9 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 ACT04337.1 - 5.8e-13 49.0 0.9 1.9e-12 47.3 0.3 2.2 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 ACT04337.1 - 1.4e-09 38.2 0.2 4.3e-09 36.6 0.2 1.9 1 0 0 1 1 1 1 PDZ domain Peptidase_M23 PF01551.22 ACT04338.1 - 3.1e-34 117.1 1.3 3.1e-34 117.1 1.3 1.9 2 0 0 2 2 1 1 Peptidase family M23 DUF3450 PF11932.8 ACT04338.1 - 0.00028 20.3 23.5 0.0027 17.1 9.7 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3450) DUF3552 PF12072.8 ACT04338.1 - 0.00029 20.3 7.6 0.00029 20.3 7.6 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) Med4 PF10018.9 ACT04338.1 - 0.0014 18.4 1.2 0.0014 18.4 1.2 2.5 2 1 0 2 2 1 1 Vitamin-D-receptor interacting Mediator subunit 4 PspA_IM30 PF04012.12 ACT04338.1 - 0.0045 16.6 9.3 0.0045 16.6 9.3 3.0 2 1 1 3 3 3 1 PspA/IM30 family Golgin_A5 PF09787.9 ACT04338.1 - 0.018 14.5 17.7 0.38 10.2 3.4 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 5 APG17 PF04108.12 ACT04338.1 - 0.025 13.7 23.4 0.27 10.3 5.6 2.1 1 1 1 2 2 2 0 Autophagy protein Apg17 Spc7 PF08317.11 ACT04338.1 - 0.029 13.2 29.2 0.38 9.6 11.2 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein CEP63 PF17045.5 ACT04338.1 - 0.037 13.9 21.8 0.055 13.4 8.2 2.3 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa MAD PF05557.13 ACT04338.1 - 0.052 11.9 23.0 0.071 11.5 4.7 2.2 2 0 0 2 2 2 0 Mitotic checkpoint protein RnfC_N PF13375.6 ACT04338.1 - 0.084 12.8 1.4 0.39 10.7 0.0 2.6 3 0 0 3 3 3 0 RnfC Barrel sandwich hybrid domain DinB PF05163.12 ACT04338.1 - 0.11 12.4 0.3 0.11 12.4 0.3 1.7 2 0 0 2 2 2 0 DinB family Fib_alpha PF08702.10 ACT04338.1 - 0.21 11.8 20.7 1.1 9.4 6.6 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4577 PF15145.6 ACT04338.1 - 0.27 11.3 2.7 0.97 9.5 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) DUF1664 PF07889.12 ACT04338.1 - 0.33 11.0 21.1 1.5 8.9 7.6 3.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 ACT04338.1 - 0.51 10.5 24.1 1.4 9.2 6.0 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 ACT04338.1 - 0.52 10.4 34.4 0.44 10.6 15.0 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Rootletin PF15035.6 ACT04338.1 - 0.71 9.9 14.0 0.33 10.9 3.3 2.2 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Mod_r PF07200.13 ACT04338.1 - 1.2 9.2 30.1 0.15 12.2 12.4 2.7 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF948 PF06103.11 ACT04338.1 - 2.2 8.6 16.2 13 6.1 2.5 4.1 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) ERM PF00769.19 ACT04338.1 - 2.7 7.7 25.1 1.3 8.8 6.4 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Vfa1 PF08432.10 ACT04338.1 - 6.3 7.1 21.5 0.19 12.1 1.9 2.8 2 1 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 TraF_2 PF13729.6 ACT04338.1 - 9.5 5.5 11.2 1.9 7.8 0.1 2.6 1 1 1 2 2 2 0 F plasmid transfer operon, TraF, protein FtsX_ECD PF18075.1 ACT04339.1 - 1.1e-23 83.7 0.7 1.6e-23 83.1 0.7 1.2 1 0 0 1 1 1 1 FtsX extracellular domain FtsX PF02687.21 ACT04339.1 - 3.5e-06 27.4 7.2 3.5e-06 27.4 7.2 3.3 3 1 0 3 3 3 1 FtsX-like permease family ACT_5 PF13710.6 ACT04339.1 - 0.045 13.6 0.9 0.17 11.8 0.9 2.0 1 0 0 1 1 1 0 ACT domain VEGFR-2_TMD PF17988.1 ACT04339.1 - 0.048 13.1 0.9 0.14 11.6 0.9 1.7 1 0 0 1 1 1 0 VEGFR-2 Transmembrane domain LptF_LptG PF03739.14 ACT04339.1 - 0.17 10.7 7.4 0.1 11.4 3.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG ABC_tran PF00005.27 ACT04340.1 - 7.3e-35 120.5 0.0 9.8e-35 120.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04340.1 - 6.5e-08 32.7 0.0 0.0037 17.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT04340.1 - 0.00013 21.5 0.0 0.11 11.9 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT04340.1 - 0.00019 21.1 0.0 0.00043 20.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 ACT04340.1 - 0.00023 21.3 0.2 0.027 14.7 0.0 2.4 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ACT04340.1 - 0.00098 19.1 0.1 0.0028 17.6 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ACT04340.1 - 0.0012 19.3 0.0 0.0018 18.7 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT04340.1 - 0.0026 18.1 0.0 0.0063 16.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ACT04340.1 - 0.0038 17.3 0.0 0.04 14.0 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 ACT04340.1 - 0.0063 16.9 0.0 0.015 15.6 0.0 1.7 2 0 0 2 2 1 1 RNA helicase AAA_30 PF13604.6 ACT04340.1 - 0.012 15.4 0.0 0.04 13.6 0.0 1.7 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ACT04340.1 - 0.028 14.3 0.4 0.5 10.3 0.0 2.1 2 0 0 2 2 2 0 NTPase Rad17 PF03215.15 ACT04340.1 - 0.029 14.3 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain IstB_IS21 PF01695.17 ACT04340.1 - 0.031 14.0 0.0 0.28 10.9 0.0 2.1 2 1 0 2 2 2 0 IstB-like ATP binding protein TsaE PF02367.17 ACT04340.1 - 0.033 14.2 0.0 0.063 13.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 ACT04340.1 - 0.048 12.8 0.1 0.23 10.6 0.0 2.0 2 1 0 2 2 2 0 NB-ARC domain AAA_18 PF13238.6 ACT04340.1 - 0.064 13.8 0.0 0.16 12.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ACT04340.1 - 0.076 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_15 PF13175.6 ACT04340.1 - 0.092 12.4 0.0 0.21 11.2 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 ACT04340.1 - 0.098 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA PF00004.29 ACT04340.1 - 0.098 13.1 0.2 0.18 12.2 0.0 1.8 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 ACT04340.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.6 1 1 0 1 1 1 0 Dynamin family Sigma54_activat PF00158.26 ACT04340.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 ACT04340.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ACT04340.1 - 0.15 11.6 0.0 0.4 10.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain VanW PF04294.13 ACT04341.1 - 1.2e-45 154.4 0.0 2.2e-45 153.5 0.0 1.5 1 0 0 1 1 1 1 VanW like protein G5 PF07501.12 ACT04341.1 - 3.8e-11 43.3 2.5 3.8e-11 43.3 2.5 2.1 2 0 0 2 2 2 1 G5 domain MTES_1575 PF18741.1 ACT04342.1 - 3.9e-06 26.9 0.0 6.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 REase_MTES_1575 DUF559 PF04480.12 ACT04342.1 - 0.0013 18.6 0.0 0.0041 17.0 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF559) HTH_11 PF08279.12 ACT04342.1 - 0.0098 15.8 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 1 HTH domain Ribosomal_S25 PF03297.15 ACT04342.1 - 0.015 15.5 0.0 0.025 14.8 0.0 1.3 1 0 0 1 1 1 0 S25 ribosomal protein RAP PF08373.10 ACT04342.1 - 0.052 13.7 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 RAP domain HTH_DeoR PF08220.12 ACT04342.1 - 0.072 12.8 0.2 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain HrcA_DNA-bdg PF03444.15 ACT04342.1 - 0.18 11.5 0.0 0.45 10.2 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding Lyase_1 PF00206.20 ACT04343.1 - 3.1e-80 269.9 0.0 5.7e-80 269.0 0.0 1.4 2 0 0 2 2 2 1 Lyase ASL_C2 PF14698.6 ACT04343.1 - 3.3e-24 85.4 0.0 9.3e-24 84.0 0.0 1.8 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Imm51 PF15595.6 ACT04343.1 - 0.087 12.8 0.5 0.27 11.2 0.1 2.0 2 0 0 2 2 2 0 Immunity protein 51 Arginosuc_synth PF00764.19 ACT04344.1 - 8.2e-153 509.3 0.0 9.3e-153 509.1 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 ACT04344.1 - 0.0019 17.7 0.0 0.0033 17.0 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 ACT04344.1 - 0.087 12.5 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase Nitrate_red_del PF02613.15 ACT04344.1 - 0.11 12.5 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Nitrate reductase delta subunit Oxygenase-NA PF09859.9 ACT04344.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA ATP_bind_3 PF01171.20 ACT04344.1 - 0.19 11.5 0.0 0.47 10.2 0.0 1.7 2 0 0 2 2 2 0 PP-loop family OTCace PF00185.24 ACT04345.1 - 1.9e-60 203.5 0.0 2.7e-60 203.0 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 ACT04345.1 - 1.8e-49 167.6 0.0 2.7e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Mur_ligase PF01225.25 ACT04345.1 - 0.031 14.6 0.0 0.075 13.4 0.0 1.8 1 1 0 1 1 1 0 Mur ligase family, catalytic domain Glyco_hydro_101 PF12905.7 ACT04345.1 - 0.033 13.6 0.0 0.048 13.1 0.0 1.2 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase Toxin_31 PF08119.11 ACT04345.1 - 0.21 11.4 0.0 0.59 9.9 0.0 1.7 2 0 0 2 2 2 0 Scorpion acidic alpha-KTx toxin family Aminotran_3 PF00202.21 ACT04346.1 - 4.2e-122 407.7 0.1 5.2e-122 407.4 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ACT04346.1 - 1.7e-06 27.5 0.0 3e-06 26.7 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ACT04346.1 - 1.3e-05 24.3 0.0 3.3e-05 23.0 0.0 1.7 1 1 1 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ACT04346.1 - 0.017 14.4 0.0 0.038 13.3 0.0 1.5 1 0 0 1 1 1 0 Beta-eliminating lyase AA_kinase PF00696.28 ACT04347.1 - 1.4e-46 159.0 2.9 1.6e-46 158.8 2.9 1.0 1 0 0 1 1 1 1 Amino acid kinase family ArgJ PF01960.18 ACT04348.1 - 1.3e-147 491.5 11.8 1.5e-147 491.3 11.8 1.0 1 0 0 1 1 1 1 ArgJ family Semialdhyde_dh PF01118.24 ACT04349.1 - 2.6e-35 121.5 0.0 1.3e-34 119.2 0.0 2.0 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 ACT04349.1 - 2e-23 83.4 0.0 3.1e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain GFO_IDH_MocA PF01408.22 ACT04349.1 - 0.0019 19.0 0.1 0.0051 17.6 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.20 ACT04349.1 - 0.0076 16.4 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus YitT_membrane PF02588.15 ACT04350.1 - 7.9e-64 214.8 14.5 1.1e-63 214.4 14.5 1.2 1 0 0 1 1 1 1 Uncharacterised 5xTM membrane BCR, YitT family COG1284 DUF2179 PF10035.9 ACT04350.1 - 3.9e-21 74.6 0.1 6.5e-21 73.8 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2179) PCRF PF03462.18 ACT04351.1 - 8e-62 208.5 0.1 3.3e-61 206.6 0.0 1.9 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 ACT04351.1 - 3.6e-44 149.4 1.6 6e-44 148.7 1.6 1.3 1 0 0 1 1 1 1 RF-1 domain Occludin_ELL PF07303.13 ACT04351.1 - 0.045 14.5 2.0 0.18 12.6 0.1 2.7 3 0 0 3 3 3 0 Occludin homology domain ABC_transp_aux PF09822.9 ACT04351.1 - 0.11 11.9 0.1 0.27 10.7 0.1 1.6 1 1 0 1 1 1 0 ABC-type uncharacterized transport system ABC_tran_CTD PF16326.5 ACT04351.1 - 0.6 10.4 0.0 0.6 10.4 0.0 4.1 3 1 2 5 5 5 0 ABC transporter C-terminal domain SecA_DEAD PF07517.14 ACT04352.1 - 4e-136 453.0 6.4 6.7e-136 452.3 6.4 1.4 1 0 0 1 1 1 1 SecA DEAD-like domain SecA_SW PF07516.13 ACT04352.1 - 2.2e-64 217.2 6.5 2.2e-64 217.2 6.5 2.1 2 1 0 2 2 2 1 SecA Wing and Scaffold domain SecA_PP_bind PF01043.20 ACT04352.1 - 3.8e-43 146.7 2.5 1.2e-42 145.0 2.5 2.0 1 0 0 1 1 1 1 SecA preprotein cross-linking domain SEC-C PF02810.15 ACT04352.1 - 7.8e-09 35.3 6.3 1.2e-08 34.7 6.3 1.3 1 0 0 1 1 1 1 SEC-C motif DEAD PF00270.29 ACT04352.1 - 6e-05 22.9 0.7 0.00037 20.3 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ACT04352.1 - 8.7e-05 22.8 0.1 0.00034 20.9 0.1 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RPW8 PF05659.11 ACT04352.1 - 0.06 13.0 1.5 0.19 11.4 0.2 2.3 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ResIII PF04851.15 ACT04352.1 - 0.26 11.3 1.7 1 9.3 0.0 2.8 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit Ribosomal_S30AE PF02482.19 ACT04353.1 - 3.9e-29 101.3 2.0 6.2e-29 100.6 2.0 1.3 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein Ribosom_S30AE_C PF16321.5 ACT04353.1 - 4.1e-28 96.8 1.1 8.8e-28 95.8 1.1 1.6 1 0 0 1 1 1 1 Sigma 54 modulation/S30EA ribosomal protein C terminus KMP11 PF03037.16 ACT04353.1 - 0.039 14.7 0.5 0.11 13.3 0.3 1.9 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 CSD PF00313.22 ACT04354.1 - 1.1e-31 108.5 1.5 1.2e-31 108.4 1.5 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 ACT04354.1 - 0.0089 15.7 0.1 0.013 15.2 0.1 1.4 1 0 0 1 1 1 1 Ribonuclease B OB domain FliT PF05400.13 ACT04355.1 - 0.057 14.2 7.7 0.082 13.7 7.7 1.3 1 0 0 1 1 1 0 Flagellar protein FliT DUF1635 PF07795.11 ACT04355.1 - 0.26 11.1 1.2 0.33 10.8 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) FliS PF02561.14 ACT04356.1 - 9.7e-33 112.9 0.1 1.2e-32 112.6 0.1 1.1 1 0 0 1 1 1 1 Flagellar protein FliS FliD_C PF07195.12 ACT04357.1 - 1.3e-47 162.3 16.1 1.3e-47 162.3 16.1 2.9 3 1 0 4 4 4 1 Flagellar hook-associated protein 2 C-terminus FliD_N PF02465.18 ACT04357.1 - 3.8e-28 98.0 6.7 3.8e-28 98.0 6.7 5.6 4 2 1 5 5 5 1 Flagellar hook-associated protein 2 N-terminus Flagellin_IN PF07196.13 ACT04357.1 - 3.4e-10 40.0 15.5 8.8e-07 29.0 4.3 5.7 4 2 1 5 5 5 2 Flagellin hook IN motif CLZ PF16526.5 ACT04357.1 - 0.089 13.2 0.2 0.44 10.9 0.2 2.2 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels UN_NPL4 PF11543.8 ACT04357.1 - 0.11 13.0 0.9 6 7.4 0.0 3.5 4 0 0 4 4 4 0 Nuclear pore localisation protein NPL4 FlaG PF03646.15 ACT04358.1 - 1.2e-23 83.2 0.5 1.9e-23 82.6 0.4 1.4 1 1 0 1 1 1 1 FlaG protein GDP_Man_Dehyd PF16363.5 ACT04359.1 - 2.5e-55 188.2 0.0 3e-55 188.0 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ACT04359.1 - 6.1e-52 176.5 0.1 7.4e-52 176.2 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ACT04359.1 - 3.1e-18 65.9 0.0 2e-17 63.3 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 ACT04359.1 - 9.7e-14 51.0 0.0 1.1e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ACT04359.1 - 1.7e-12 47.0 0.0 2.4e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 ACT04359.1 - 5.4e-07 29.3 0.0 7.2e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT04359.1 - 6.5e-07 29.4 0.0 1.2e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 ACT04359.1 - 2.7e-06 26.7 0.6 3.9e-05 22.9 0.6 2.4 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 ACT04359.1 - 0.00067 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT04359.1 - 0.019 14.5 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 NmrA-like family HDC PF02329.16 ACT04359.1 - 0.065 12.2 0.1 0.19 10.7 0.0 1.7 2 0 0 2 2 2 0 Histidine carboxylase PI chain RuvC PF02075.17 ACT04359.1 - 0.13 12.1 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Crossover junction endodeoxyribonuclease RuvC Methyltransf_21 PF05050.12 ACT04360.1 - 4.8e-15 56.0 0.5 6.1e-15 55.7 0.5 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain Met_10 PF02475.16 ACT04360.1 - 4.2e-05 23.4 0.1 7e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein V_cholerae_RfbT PF05575.11 ACT04360.1 - 0.00014 21.2 0.1 0.00017 21.0 0.1 1.2 1 0 0 1 1 1 1 Vibrio cholerae RfbT protein PCMT PF01135.19 ACT04360.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Glycos_transf_1 PF00534.20 ACT04361.1 - 4e-33 114.4 0.0 6.4e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT04361.1 - 7.7e-25 87.9 0.0 3e-24 86.0 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACT04361.1 - 2.7e-20 73.1 0.0 7.4e-20 71.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 ACT04361.1 - 6.6e-11 42.5 0.0 1.4e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ACT04361.1 - 4.8e-10 40.1 0.0 1.2e-09 38.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Hexapep PF00132.24 ACT04362.1 - 5e-12 45.1 11.2 8.7e-12 44.3 4.4 3.6 4 0 0 4 4 4 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACT04362.1 - 1.5e-08 34.2 4.1 1.5e-08 34.2 4.1 2.1 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase BsuBI_PstI_RE PF06616.11 ACT04362.1 - 0.056 12.7 0.5 0.14 11.4 0.2 1.8 2 0 0 2 2 2 0 BsuBI/PstI restriction endonuclease domain Glycos_transf_1 PF00534.20 ACT04363.1 - 1.2e-20 73.7 0.0 3.2e-20 72.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT04363.1 - 9.2e-15 55.3 0.0 2e-14 54.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ACT04363.1 - 3.8e-11 43.2 0.0 9.3e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_2 PF00535.26 ACT04364.1 - 3.2e-23 82.4 0.4 6.9e-23 81.3 0.4 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 TPR_1 PF00515.28 ACT04364.1 - 2.1e-12 46.3 29.1 6e-05 22.7 1.1 6.9 7 0 0 7 7 7 4 Tetratricopeptide repeat Glyco_tranf_2_4 PF13704.6 ACT04364.1 - 1.1e-11 45.1 0.1 3.4e-11 43.5 0.1 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 2 TPR_2 PF07719.17 ACT04364.1 - 6e-11 41.6 20.1 0.0012 18.8 0.5 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat Glyco_tranf_2_2 PF10111.9 ACT04364.1 - 9.8e-08 31.8 0.4 2.8e-07 30.3 0.4 1.7 1 0 0 1 1 1 1 Glycosyltransferase like family 2 TPR_17 PF13431.6 ACT04364.1 - 7.3e-06 26.0 6.5 0.13 12.7 0.0 5.4 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ACT04364.1 - 1.3e-05 25.6 1.3 0.11 13.0 0.2 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ACT04364.1 - 2e-05 25.1 0.1 3.4 8.4 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ACT04364.1 - 0.00011 22.1 25.3 0.32 11.3 0.2 6.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 ACT04364.1 - 0.00039 20.7 8.9 4.5 7.6 0.0 5.2 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ACT04364.1 - 0.00045 20.7 6.5 8.1 7.3 0.0 5.7 6 0 0 6 6 5 1 Tetratricopeptide repeat Glyco_tranf_2_3 PF13641.6 ACT04364.1 - 0.0018 18.2 0.0 0.0035 17.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 TPR_14 PF13428.6 ACT04364.1 - 0.017 15.9 0.0 70 4.6 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ACT04364.1 - 0.028 14.6 12.3 1.4 9.2 0.1 4.6 4 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 ACT04364.1 - 0.23 11.6 7.0 11 6.2 0.3 3.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.20 ACT04364.1 - 0.41 11.0 1.9 16 6.0 0.2 3.6 3 0 0 3 3 3 0 PPR repeat TPR_7 PF13176.6 ACT04364.1 - 8.7 6.6 8.2 5.8 7.2 0.2 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat Flagellin_N PF00669.20 ACT04365.1 - 5.3e-45 152.9 17.6 5.3e-45 152.9 17.6 4.5 3 2 0 4 4 4 1 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 ACT04365.1 - 4.3e-29 100.7 7.6 4.3e-29 100.7 7.6 3.7 4 0 0 4 4 4 1 Bacterial flagellin C-terminal helical region DUF592 PF04574.13 ACT04365.1 - 0.00019 21.2 0.2 0.0023 17.7 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF592) PliI PF16743.5 ACT04365.1 - 0.00029 20.6 0.3 0.0013 18.4 0.2 2.3 2 0 0 2 2 2 1 Periplasmic lysozyme inhibitor of I-type lysozyme DUF4115 PF13464.6 ACT04365.1 - 0.00088 19.4 2.0 0.26 11.5 0.1 3.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4115) MotY_N PF18393.1 ACT04365.1 - 0.17 12.0 0.1 2.1 8.5 0.1 2.7 3 0 0 3 3 3 0 MotY N-terminal domain Fimbrial_PilY2 PF14481.6 ACT04365.1 - 0.33 10.6 2.3 0.49 10.1 0.1 2.4 3 0 0 3 3 3 0 Type 4 fimbrial biogenesis protein PilY2 IFT57 PF10498.9 ACT04365.1 - 0.6 9.0 8.9 0.74 8.7 1.5 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 CsrA PF02599.16 ACT04366.1 - 1.5e-24 85.7 1.4 2e-24 85.2 1.4 1.2 1 0 0 1 1 1 1 Global regulator protein family FliW PF02623.15 ACT04367.1 - 9.4e-38 128.8 0.0 1e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 FliW protein Flagellin_N PF00669.20 ACT04369.1 - 6.6e-25 87.8 9.3 6.6e-25 87.8 9.3 2.4 2 0 0 2 2 2 2 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 ACT04369.1 - 2.4e-11 43.8 3.8 2.4e-11 43.8 3.8 2.9 3 1 0 3 3 3 1 Bacterial flagellin C-terminal helical region Flg_bbr_C PF06429.13 ACT04370.1 - 3.8e-12 46.2 1.1 3.8e-12 46.2 1.1 2.3 2 0 0 2 2 2 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 ACT04370.1 - 0.00022 21.1 0.8 0.00022 21.1 0.8 3.3 3 0 0 3 3 3 1 Flagella basal body rod protein COG2 PF06148.11 ACT04370.1 - 0.1 12.7 3.0 0.92 9.6 0.2 2.7 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF2857 PF11198.8 ACT04370.1 - 0.22 11.3 1.5 1.8 8.3 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2857) TolA_bind_tri PF16331.5 ACT04370.1 - 3.2 7.9 8.6 1.6 8.8 0.2 3.5 4 0 0 4 4 4 0 TolA binding protein trimerisation FlgN PF05130.12 ACT04371.1 - 3.5e-16 60.0 12.8 4.2e-16 59.8 12.8 1.1 1 0 0 1 1 1 1 FlgN protein Plasmid_RAQPRD PF09686.10 ACT04371.1 - 1 9.6 7.7 0.3 11.3 1.4 2.4 2 1 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Elf4 PF07011.11 ACT04371.1 - 1.9 8.5 5.8 3.9 7.4 0.7 2.4 2 0 0 2 2 2 0 Early Flowering 4 domain FlgM PF04316.13 ACT04372.1 - 2.5e-16 59.8 0.6 3.7e-16 59.2 0.6 1.3 1 0 0 1 1 1 1 Anti-sigma-28 factor, FlgM TipAS PF07739.13 ACT04372.1 - 0.015 15.8 1.1 0.018 15.6 1.1 1.0 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain Aldedh PF00171.22 ACT04372.1 - 0.022 13.3 0.4 0.025 13.1 0.4 1.0 1 0 0 1 1 1 0 Aldehyde dehydrogenase family Caudo_TAP PF02413.17 ACT04372.1 - 0.044 13.9 0.9 0.052 13.7 0.9 1.1 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK WWE PF02825.20 ACT04372.1 - 0.057 14.0 0.5 0.63 10.7 0.5 2.0 1 1 0 1 1 1 0 WWE domain Nuc_deoxyri_tr2 PF15891.5 ACT04372.1 - 0.11 12.8 0.2 0.13 12.6 0.2 1.4 1 1 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase like RecR PF02132.15 ACT04373.1 - 0.00042 19.8 8.9 0.023 14.3 1.3 2.5 2 0 0 2 2 2 2 RecR protein DZR PF12773.7 ACT04373.1 - 0.00046 20.1 9.3 0.049 13.7 9.3 2.7 1 1 0 1 1 1 1 Double zinc ribbon zinc-ribbons_6 PF07191.12 ACT04373.1 - 0.0013 18.7 5.1 0.18 11.8 0.2 2.3 2 0 0 2 2 2 2 zinc-ribbons Ribosomal_L32p PF01783.23 ACT04373.1 - 0.0042 17.3 3.3 0.11 12.7 0.3 2.5 2 0 0 2 2 2 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 ACT04373.1 - 0.011 15.1 11.7 0.17 11.3 0.4 2.8 2 1 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 ACT04373.1 - 0.021 14.3 10.1 0.2 11.2 0.0 3.8 2 2 1 3 3 3 0 TFIIB zinc-binding NMD3 PF04981.13 ACT04373.1 - 0.028 13.9 6.2 0.47 9.9 0.5 2.5 2 1 0 2 2 2 0 NMD3 family Linker_histone PF00538.19 ACT04373.1 - 0.033 14.5 0.1 0.081 13.3 0.0 1.7 2 0 0 2 2 2 0 linker histone H1 and H5 family zf-C2HC5 PF06221.13 ACT04373.1 - 0.14 12.2 9.3 1.9 8.5 1.5 2.6 2 1 0 2 2 2 0 Putative zinc finger motif, C2HC5-type zf-C3HC4_3 PF13920.6 ACT04373.1 - 0.16 11.8 9.8 0.99 9.3 1.5 2.6 3 0 0 3 3 2 0 Zinc finger, C3HC4 type (RING finger) NOB1_Zn_bind PF08772.11 ACT04373.1 - 0.22 11.7 4.5 7.6 6.8 0.5 2.4 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_2 PF13240.6 ACT04373.1 - 0.47 10.2 14.3 8.7 6.2 1.8 4.2 3 1 0 3 3 3 0 zinc-ribbon domain zf-CHY PF05495.12 ACT04373.1 - 0.76 10.3 6.1 2.5 8.6 0.2 2.5 2 0 0 2 2 2 0 CHY zinc finger zinc_ribbon_15 PF17032.5 ACT04373.1 - 1.1 10.0 10.8 13 6.6 0.6 3.1 2 2 0 2 2 2 0 zinc-ribbon family NinF PF05810.12 ACT04373.1 - 1.1 9.1 5.2 3.7 7.5 1.0 2.3 2 0 0 2 2 2 0 NinF protein DUF2116 PF09889.9 ACT04373.1 - 1.2 9.2 8.2 1.6 8.8 0.8 2.9 2 1 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) zf_UBZ PF18439.1 ACT04373.1 - 1.3 8.7 15.5 4.1 7.1 0.2 4.1 2 2 2 4 4 4 0 Ubiquitin-Binding Zinc Finger HypA PF01155.19 ACT04373.1 - 1.5 8.9 8.3 7.8 6.6 0.9 2.3 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_2 PF03107.16 ACT04373.1 - 2.1 8.8 8.2 0.86 10.0 0.2 2.7 2 1 0 2 2 2 0 C1 domain Auto_anti-p27 PF06677.12 ACT04373.1 - 2.1 8.5 12.7 5.6 7.2 2.6 3.3 2 1 1 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-FPG_IleRS PF06827.14 ACT04373.1 - 2.2 8.2 14.1 5.9 6.8 0.1 4.1 4 1 1 5 5 4 0 Zinc finger found in FPG and IleRS PolC_DP2 PF03833.13 ACT04373.1 - 3.5 5.4 6.6 1.1 7.0 0.7 2.0 1 1 1 2 2 2 0 DNA polymerase II large subunit DP2 DUF35_N PF12172.8 ACT04373.1 - 4.5 7.3 7.7 15 5.5 0.3 3.3 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-MYND PF01753.18 ACT04373.1 - 7 6.8 9.9 6.5 6.9 1.0 2.4 2 0 0 2 2 2 0 MYND finger Prok-RING_1 PF14446.6 ACT04373.1 - 9.7 6.2 12.9 4.3 7.3 2.4 3.1 2 2 3 5 5 5 0 Prokaryotic RING finger family 1 Pribosyltran PF00156.27 ACT04374.1 - 0.0011 18.5 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 ACT04374.1 - 0.03 13.8 0.1 0.046 13.2 0.1 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase Helicase_C PF00271.31 ACT04375.1 - 5e-13 49.4 0.0 1.3e-12 48.0 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ACT04375.1 - 2.8e-07 30.7 0.0 4.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ACT04375.1 - 1.7e-06 27.9 0.0 3.9e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 ACT04375.1 - 0.013 15.5 0.0 0.038 14.0 0.0 1.7 1 1 0 1 1 1 0 Flavivirus DEAD domain TrwB_AAD_bind PF10412.9 ACT04375.1 - 0.13 11.2 0.0 0.27 10.1 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Ribosomal_L37e PF01907.19 ACT04375.1 - 6.2 7.1 13.7 13 6.1 13.7 1.5 1 0 0 1 1 1 0 Ribosomal protein L37e Glyco_tranf_2_4 PF13704.6 ACT04376.1 - 0.00018 21.9 0.0 0.00028 21.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glycos_transf_2 PF00535.26 ACT04376.1 - 0.003 17.4 0.0 0.0043 16.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 PGM_PMM_I PF02878.16 ACT04376.1 - 0.091 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I MTES_1575 PF18741.1 ACT04377.1 - 1.2e-05 25.3 0.1 2.3e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 REase_MTES_1575 DUF559 PF04480.12 ACT04377.1 - 0.0052 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF559) SMC_ScpB PF04079.16 ACT04377.1 - 0.079 12.6 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB HTH_12 PF08461.10 ACT04377.1 - 0.09 12.7 0.8 0.15 12.0 0.2 1.7 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain RAP PF08373.10 ACT04377.1 - 0.1 12.7 0.0 0.27 11.4 0.0 1.8 2 0 0 2 2 2 0 RAP domain DUF2240 PF09999.9 ACT04377.1 - 0.12 12.0 0.0 0.67 9.6 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2240) Response_reg PF00072.24 ACT04378.1 - 1.3e-25 89.7 0.3 2.2e-25 89.0 0.3 1.4 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 ACT04378.1 - 7.7e-23 79.8 0.2 1.8e-22 78.6 0.2 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACT04378.1 - 3.5e-05 23.4 0.0 6.3e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT04378.1 - 0.0033 16.9 0.2 0.0087 15.6 0.1 1.8 1 1 1 2 2 2 1 Sigma-70, region 4 HTH_23 PF13384.6 ACT04378.1 - 0.0068 16.2 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Glyco_transf_25 PF01755.17 ACT04378.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) Plk4_PB1 PF18190.1 ACT04378.1 - 0.12 12.5 0.1 0.85 9.8 0.0 2.2 2 0 0 2 2 2 0 Polo-like Kinase 4 Polo Box 1 DegS PF05384.11 ACT04379.1 - 1.7e-54 183.6 20.8 2.2e-54 183.2 17.0 2.3 2 0 0 2 2 2 1 Sensor protein DegS HisKA_3 PF07730.13 ACT04379.1 - 6.4e-15 55.4 0.4 6.4e-15 55.4 0.4 3.5 4 1 0 4 4 4 1 Histidine kinase HATPase_c PF02518.26 ACT04379.1 - 5.1e-09 36.6 0.3 1.4e-08 35.2 0.3 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT04379.1 - 2.3e-06 27.6 0.7 3.4e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain FAP206 PF12018.8 ACT04379.1 - 0.019 14.5 4.2 0.039 13.5 4.2 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF1664 PF07889.12 ACT04379.1 - 0.045 13.8 0.8 0.045 13.8 0.8 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4495 PF14906.6 ACT04379.1 - 0.067 12.2 0.4 6.5 5.7 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4495) DUF948 PF06103.11 ACT04379.1 - 0.56 10.5 4.8 15 5.9 0.2 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF745 PF05335.13 ACT04379.1 - 1.8 8.2 5.0 13 5.4 1.9 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Baculo_PEP_C PF04513.12 ACT04379.1 - 4 7.5 7.4 4.2 7.4 0.5 3.1 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4315 PF14193.6 ACT04379.1 - 8.8 6.4 11.6 1.3 9.1 3.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) Cu_amine_oxidN1 PF07833.11 ACT04380.1 - 7.7e-38 128.9 5.8 1.8e-24 86.0 0.7 4.1 3 1 1 4 4 4 2 Copper amine oxidase N-terminal domain NAGPA PF09992.9 ACT04380.1 - 4e-35 121.5 9.3 7.1e-31 107.7 1.8 3.7 4 0 0 4 4 4 2 Phosphodiester glycosidase P22_AR_N PF10547.9 ACT04380.1 - 0.18 12.1 0.0 4.1 7.8 0.0 2.3 1 1 1 2 2 2 0 P22_AR N-terminal domain Big_3 PF07523.12 ACT04380.1 - 0.61 10.4 11.6 0.091 13.1 0.9 3.9 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) Big_5 PF13205.6 ACT04382.1 - 8.6e-82 270.9 88.4 6.7e-21 75.0 1.0 10.0 7 1 2 9 9 9 7 Bacterial Ig-like domain SWM_repeat PF13753.6 ACT04382.1 - 1.5e-56 188.5 42.8 2.3e-19 69.3 0.1 8.5 8 0 0 8 8 8 4 Putative flagellar system-associated repeat SLH PF00395.20 ACT04382.1 - 1.1e-31 108.5 8.7 4.1e-12 45.9 0.2 4.9 4 0 0 4 4 4 3 S-layer homology domain CopC PF04234.12 ACT04382.1 - 3.2e-09 37.7 18.0 0.45 11.6 0.0 9.0 8 1 1 9 9 9 3 CopC domain Collagen_bind_2 PF12904.7 ACT04382.1 - 0.028 14.4 0.1 2.5 8.2 0.0 3.0 2 0 0 2 2 2 0 Putative collagen-binding domain of a collagenase DUF1329 PF07044.11 ACT04382.1 - 0.045 13.0 0.1 0.083 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1329) FeS_assembly_P PF01883.19 ACT04382.1 - 0.3 11.3 1.5 1 9.6 0.0 2.7 3 0 0 3 3 3 0 Iron-sulfur cluster assembly protein LytR_cpsA_psr PF03816.14 ACT04382.1 - 0.65 10.1 5.0 4.3 7.5 0.1 3.8 4 0 0 4 4 4 0 Cell envelope-related transcriptional attenuator domain S-AdoMet_synt_C PF02773.16 ACT04383.1 - 9.7e-72 239.4 1.3 2.4e-71 238.1 0.1 2.0 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 ACT04383.1 - 1.7e-50 170.2 0.0 3.3e-50 169.3 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 ACT04383.1 - 2.8e-41 140.2 1.0 4.6e-41 139.5 0.1 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 ACT04383.1 - 0.13 11.0 1.5 0.36 9.6 0.1 2.1 2 1 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) SASP PF00269.20 ACT04384.1 - 8.4e-24 83.4 0.5 7.1e-22 77.2 0.5 2.0 1 1 0 1 1 1 1 Small, acid-soluble spore proteins, alpha/beta type DUF2381 PF09544.10 ACT04386.1 - 0.043 13.4 0.1 3.7 7.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2381) DUF5111 PF17138.4 ACT04386.1 - 0.68 9.8 9.1 0.028 14.2 1.2 2.8 3 1 1 4 4 4 0 Domain of unknown function (DUF5111) SLH PF00395.20 ACT04387.1 - 3.3e-26 91.0 1.8 7.5e-12 45.1 0.0 3.1 2 0 0 2 2 2 2 S-layer homology domain PASTA PF03793.19 ACT04387.1 - 0.038 13.8 5.6 0.08 12.8 0.0 4.2 3 1 1 4 4 4 0 PASTA domain SLH PF00395.20 ACT04388.1 - 1.3e-14 54.0 9.1 2.2e-06 27.6 0.0 4.6 4 0 0 4 4 4 3 S-layer homology domain Glucodextran_B PF09136.10 ACT04388.1 - 0.00062 20.1 0.6 0.0072 16.7 0.6 3.0 1 0 0 1 1 1 1 Glucodextranase, domain B RecJ_OB PF17768.1 ACT04388.1 - 0.12 12.6 0.2 0.33 11.2 0.2 1.7 1 0 0 1 1 1 0 RecJ OB domain Glycos_transf_4 PF00953.21 ACT04389.1 - 4.5e-44 150.2 21.1 4.5e-44 150.2 21.1 2.5 3 0 0 3 3 3 1 Glycosyl transferase family 4 PrgI PF12666.7 ACT04389.1 - 0.025 15.3 0.2 0.025 15.3 0.2 4.8 4 2 1 5 5 5 0 PrgI family protein DDDD PF10161.9 ACT04389.1 - 3.4 7.5 4.7 6 6.7 0.5 2.8 2 0 0 2 2 2 0 Putative mitochondrial precursor protein Glyco_tran_WecB PF03808.13 ACT04390.1 - 3.7e-61 206.0 0.1 5.8e-61 205.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase WecB/TagA/CpsF family Epimerase_2 PF02350.19 ACT04390.1 - 0.02 13.8 0.0 0.027 13.3 0.0 1.3 1 1 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Methyltransf_25 PF13649.6 ACT04390.1 - 0.12 13.1 0.0 0.35 11.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Mn_catalase PF05067.12 ACT04390.1 - 0.14 11.1 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Manganese containing catalase PS_pyruv_trans PF04230.13 ACT04391.1 - 1.6e-36 126.7 0.0 2.5e-36 126.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide pyruvyl transferase Glyco_trans_4_4 PF13579.6 ACT04391.1 - 0.0042 17.5 5.4 0.0046 17.4 0.2 2.8 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 ACT04391.1 - 0.14 12.2 0.1 0.37 10.8 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase Family 4 UPF0715 PF17094.5 ACT04392.1 - 0.44 11.1 7.0 1.5 9.4 7.0 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0715) Sigma_reg_N PF13800.6 ACT04392.1 - 0.94 9.8 5.7 9 6.7 0.0 3.3 3 0 0 3 3 3 0 Sigma factor regulator N-terminal PGM_PMM_I PF02878.16 ACT04393.1 - 1.1e-40 138.6 0.0 2.3e-40 137.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 ACT04393.1 - 3.5e-25 88.4 0.1 6.8e-25 87.5 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 ACT04393.1 - 1.6e-23 83.3 0.0 4.1e-23 82.0 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 ACT04393.1 - 1.7e-10 40.9 0.0 4.7e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain FabA PF07977.13 ACT04394.1 - 9e-35 119.3 0.0 1e-34 119.1 0.0 1.0 1 0 0 1 1 1 1 FabA-like domain MaoC_dehydratas PF01575.19 ACT04394.1 - 0.0033 17.0 0.0 0.0046 16.5 0.0 1.4 1 1 0 1 1 1 1 MaoC like domain 4HBT PF03061.22 ACT04394.1 - 0.0061 16.9 0.0 0.013 15.8 0.0 1.6 1 1 0 1 1 1 1 Thioesterase superfamily MazE_antitoxin PF04014.18 ACT04394.1 - 0.053 13.5 0.1 0.099 12.6 0.1 1.4 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin CDP-OH_P_transf PF01066.21 ACT04395.1 - 1.5e-16 60.9 1.3 1.5e-16 60.9 1.3 2.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase EpuA PF11772.8 ACT04396.1 - 1e-12 47.5 2.1 1.5e-12 47.0 2.1 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase subunit beta Flg_bbr_C PF06429.13 ACT04397.1 - 1.3e-18 66.9 3.0 1.3e-18 66.9 3.0 2.9 3 1 0 3 3 3 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 ACT04397.1 - 1.1e-09 38.0 3.4 2.4e-09 36.9 2.2 2.3 2 0 0 2 2 2 1 Flagella basal body rod protein Flg_bbr_C PF06429.13 ACT04398.1 - 5e-18 65.0 0.3 1.4e-17 63.6 0.3 1.8 1 0 0 1 1 1 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 ACT04398.1 - 1.1e-10 41.2 1.1 1.1e-10 41.2 1.1 2.2 3 0 0 3 3 3 1 Flagella basal body rod protein MreB_Mbl PF06723.13 ACT04399.1 - 4.5e-147 489.1 6.3 5.1e-147 488.9 6.3 1.0 1 0 0 1 1 1 1 MreB/Mbl protein HSP70 PF00012.20 ACT04399.1 - 3.5e-11 42.0 0.9 4.5e-10 38.4 0.1 2.1 2 0 0 2 2 2 1 Hsp70 protein FtsA PF14450.6 ACT04399.1 - 1.3e-09 38.4 1.3 4.5e-09 36.7 0.1 2.2 2 0 0 2 2 2 1 Cell division protein FtsA Actin PF00022.19 ACT04399.1 - 7.1e-09 34.8 0.0 5.1e-06 25.4 0.0 2.0 2 0 0 2 2 2 2 Actin EutA PF06277.11 ACT04399.1 - 5.1e-06 25.6 1.9 1.9e-05 23.8 0.5 2.1 1 1 1 2 2 2 1 Ethanolamine utilisation protein EutA DDR PF08841.10 ACT04399.1 - 5.9e-05 22.2 1.4 0.00062 18.9 0.4 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain PilM_2 PF11104.8 ACT04399.1 - 0.00069 18.7 0.3 0.19 10.7 0.0 2.5 3 0 0 3 3 3 2 Type IV pilus assembly protein PilM; Hydantoinase_A PF01968.18 ACT04399.1 - 0.018 14.3 0.4 0.031 13.5 0.4 1.3 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Ppx-GppA PF02541.16 ACT04399.1 - 0.034 13.6 0.1 0.075 12.5 0.1 1.5 1 0 0 1 1 1 0 Ppx/GppA phosphatase family MutL PF13941.6 ACT04399.1 - 0.046 12.3 0.2 0.071 11.7 0.2 1.3 1 0 0 1 1 1 0 MutL protein Fumble PF03630.14 ACT04399.1 - 0.095 11.9 0.0 0.2 10.8 0.0 1.6 1 1 0 1 1 1 0 Fumble Linker_histone PF00538.19 ACT04399.1 - 0.13 12.6 0.1 7.4 7.0 0.1 2.5 2 0 0 2 2 2 0 linker histone H1 and H5 family SpoIIID PF12116.8 ACT04400.1 - 1.6e-39 133.8 2.7 2e-39 133.6 2.7 1.1 1 0 0 1 1 1 1 Stage III sporulation protein D HTH_7 PF02796.15 ACT04400.1 - 7.6e-05 22.7 0.1 0.00033 20.7 0.1 2.0 1 1 1 2 2 2 1 Helix-turn-helix domain of resolvase HTH_38 PF13936.6 ACT04400.1 - 7.7e-05 22.4 0.1 0.0012 18.6 0.1 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_11 PF08279.12 ACT04400.1 - 0.0001 22.2 0.1 0.00016 21.5 0.1 1.3 1 0 0 1 1 1 1 HTH domain HTH_23 PF13384.6 ACT04400.1 - 0.00049 19.8 0.1 0.00092 18.9 0.1 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_10 PF04967.12 ACT04400.1 - 0.0022 17.7 0.0 0.0042 16.9 0.0 1.4 1 0 0 1 1 1 1 HTH DNA binding domain HTH_22 PF13309.6 ACT04400.1 - 0.0031 17.6 0.4 0.0078 16.3 0.0 1.8 2 0 0 2 2 2 1 HTH domain HTH_50 PF18024.1 ACT04400.1 - 0.0037 16.8 0.4 0.22 11.2 0.0 2.2 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_DeoR PF08220.12 ACT04400.1 - 0.0064 16.2 0.1 0.015 15.0 0.1 1.6 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 ACT04400.1 - 0.0075 15.7 0.1 0.013 15.0 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 LZ_Tnp_IS481 PF13011.6 ACT04400.1 - 0.0087 16.6 0.0 0.016 15.7 0.0 1.5 1 1 0 1 1 1 1 leucine-zipper of insertion element IS481 UPF0047 PF01894.17 ACT04400.1 - 0.016 15.3 0.1 0.017 15.2 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0047 LacI PF00356.21 ACT04400.1 - 0.018 14.8 0.2 0.042 13.7 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family HTH_IclR PF09339.10 ACT04400.1 - 0.023 14.5 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain Sigma70_r4 PF04545.16 ACT04400.1 - 0.026 14.1 0.0 0.061 12.9 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_40 PF14493.6 ACT04400.1 - 0.03 14.8 0.4 0.057 13.9 0.4 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain GntR PF00392.21 ACT04400.1 - 0.055 13.1 0.0 0.093 12.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family TetR_N PF00440.23 ACT04400.1 - 0.061 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family MarR_2 PF12802.7 ACT04400.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 MarR family HTH_36 PF13730.6 ACT04400.1 - 0.12 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_4 PF13613.6 ACT04400.1 - 0.17 11.7 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Peptidase_M23 PF01551.22 ACT04401.1 - 3.2e-24 85.0 0.2 5.3e-24 84.3 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M23 RnfC_N PF13375.6 ACT04401.1 - 0.0022 17.9 0.3 1.8 8.5 0.0 2.5 2 0 0 2 2 2 2 RnfC Barrel sandwich hybrid domain DUF3671 PF12420.8 ACT04401.1 - 0.03 14.4 0.0 0.048 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function LtrA PF06772.11 ACT04401.1 - 0.081 12.1 0.1 0.11 11.8 0.1 1.1 1 0 0 1 1 1 0 Bacterial low temperature requirement A protein (LtrA) SpoIID PF08486.10 ACT04402.1 - 4.6e-24 84.8 0.1 8.6e-24 83.9 0.1 1.5 1 0 0 1 1 1 1 Stage II sporulation protein Ta0938 PF11494.8 ACT04402.1 - 0.026 14.8 0.0 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 Ta0938 MacB_PCD PF12704.7 ACT04403.1 - 2.4e-31 109.6 8.1 4.8e-31 108.6 8.1 1.5 1 0 0 1 1 1 1 MacB-like periplasmic core domain FtsX PF02687.21 ACT04403.1 - 2e-13 50.6 0.8 2e-13 50.6 0.8 3.0 3 0 0 3 3 3 1 FtsX-like permease family DUF4396 PF14342.6 ACT04403.1 - 0.13 12.6 0.1 0.13 12.6 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4396) DUF3021 PF11457.8 ACT04403.1 - 0.51 10.7 8.8 0.43 10.9 2.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3021) ABC_tran PF00005.27 ACT04404.1 - 9.7e-35 120.1 0.0 1.4e-34 119.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT04404.1 - 4.7e-10 39.3 0.1 1.4e-05 24.7 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ACT04404.1 - 2.7e-07 30.7 0.0 0.0032 17.3 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT04404.1 - 5e-05 22.9 0.1 9.7e-05 22.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ACT04404.1 - 0.0023 18.2 0.1 0.017 15.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ACT04404.1 - 0.0025 17.7 0.0 0.0039 17.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 ACT04404.1 - 0.0036 17.5 0.2 0.68 10.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ACT04404.1 - 0.0085 15.3 0.1 0.14 11.3 0.1 2.0 2 0 0 2 2 2 1 NB-ARC domain AAA_23 PF13476.6 ACT04404.1 - 0.0087 16.6 0.1 0.015 15.8 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ACT04404.1 - 0.016 15.0 0.3 0.87 9.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ACT04404.1 - 0.019 15.3 0.5 0.065 13.6 0.5 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 ACT04404.1 - 0.025 14.3 0.1 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ACT04404.1 - 0.043 13.9 0.1 0.11 12.5 0.1 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase Rad17 PF03215.15 ACT04404.1 - 0.045 13.7 0.0 0.068 13.1 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain APS_kinase PF01583.20 ACT04404.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase HlyD_3 PF13437.6 ACT04405.1 - 7.1e-17 62.0 1.8 1.4e-13 51.5 0.7 2.5 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 ACT04405.1 - 3.2e-16 59.2 5.7 5.2e-15 55.3 5.7 2.0 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 ACT04405.1 - 2.8e-10 39.8 1.9 1e-07 31.6 0.0 2.5 2 0 0 2 2 2 2 Biotin-lipoyl like Biotin_lipoyl PF00364.22 ACT04405.1 - 4.1e-06 26.5 0.8 0.0028 17.4 0.0 2.6 2 0 0 2 2 2 2 Biotin-requiring enzyme AAA_13 PF13166.6 ACT04405.1 - 0.00016 20.5 5.0 0.0002 20.2 5.0 1.1 1 0 0 1 1 1 1 AAA domain PYNP_C PF07831.13 ACT04405.1 - 0.0021 17.7 1.8 0.22 11.2 0.1 3.3 2 1 1 3 3 3 1 Pyrimidine nucleoside phosphorylase C-terminal domain DUF3584 PF12128.8 ACT04405.1 - 0.0068 14.0 3.5 0.0094 13.5 3.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Cob_adeno_trans PF01923.18 ACT04405.1 - 0.012 15.8 0.4 0.022 14.9 0.4 1.4 1 0 0 1 1 1 0 Cobalamin adenosyltransferase RnfC_N PF13375.6 ACT04405.1 - 0.017 15.1 1.0 1.2 9.2 0.0 3.2 2 1 1 3 3 3 0 RnfC Barrel sandwich hybrid domain Apolipoprotein PF01442.18 ACT04405.1 - 0.024 14.5 2.4 0.039 13.8 2.4 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain AAA_32 PF13654.6 ACT04405.1 - 0.039 12.7 3.7 0.054 12.3 3.7 1.1 1 0 0 1 1 1 0 AAA domain RasGAP_C PF03836.15 ACT04405.1 - 0.11 12.6 4.6 0.22 11.6 4.6 1.4 1 0 0 1 1 1 0 RasGAP C-terminus DUF713 PF05218.14 ACT04405.1 - 0.17 11.6 4.2 0.29 10.8 4.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF713) DUF4795 PF16043.5 ACT04405.1 - 0.17 11.4 5.2 0.34 10.5 5.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Atg14 PF10186.9 ACT04405.1 - 0.18 10.8 1.2 0.24 10.4 1.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5039 PF16442.5 ACT04405.1 - 0.2 11.2 5.1 0.32 10.5 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5039) DUF724 PF05266.14 ACT04405.1 - 0.56 10.0 3.0 0.97 9.2 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TMPIT PF07851.13 ACT04405.1 - 0.61 9.3 2.8 0.9 8.7 2.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein V_ATPase_I PF01496.19 ACT04405.1 - 0.76 7.6 2.5 1 7.2 2.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 ACT04405.1 - 1.2 8.5 9.3 2.2 7.5 9.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Prefoldin PF02996.17 ACT04405.1 - 4.7 7.1 13.5 6.9 6.6 1.8 2.8 2 1 1 3 3 3 0 Prefoldin subunit EPSP_synthase PF00275.20 ACT04406.1 - 8.9e-109 363.9 4.8 1e-108 363.7 4.8 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DUF1146 PF06612.11 ACT04407.1 - 6.4e-15 54.9 3.1 6.4e-15 54.9 3.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1146) Peptidase_S8 PF00082.22 ACT04408.1 - 5.4e-45 153.9 0.0 8.4e-45 153.3 0.0 1.3 1 0 0 1 1 1 1 Subtilase family SLH PF00395.20 ACT04408.1 - 1.9e-38 130.2 0.6 1.4e-14 53.8 0.2 3.9 3 0 0 3 3 3 3 S-layer homology domain PPC PF04151.15 ACT04408.1 - 1.7e-07 32.2 3.3 0.01 16.9 0.0 4.3 4 1 0 4 4 4 2 Bacterial pre-peptidase C-terminal domain Proton_antipo_M PF00361.20 ACT04409.1 - 1.5e-61 208.2 26.9 1.5e-61 208.2 26.9 2.4 3 0 0 3 3 3 1 Proton-conducting membrane transporter Proton_antipo_M PF00361.20 ACT04410.1 - 3.5e-65 220.1 22.3 3.5e-65 220.1 22.3 1.9 2 0 0 2 2 2 1 Proton-conducting membrane transporter Oxidored_q5_N PF01059.17 ACT04410.1 - 5.7e-05 23.2 0.2 5.7e-05 23.2 0.2 4.2 4 1 1 5 5 5 2 NADH-ubiquinone oxidoreductase chain 4, amino terminus Proton_antipo_M PF00361.20 ACT04411.1 - 1.7e-86 290.1 25.5 1.7e-86 290.1 25.5 2.4 1 1 1 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 ACT04411.1 - 9.6e-18 64.0 0.9 5.1e-17 61.7 0.9 2.4 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Proton_antipo_C PF01010.19 ACT04411.1 - 6.5e-06 26.0 0.5 0.00054 19.7 0.5 2.8 1 1 0 1 1 1 1 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus NADH5_C PF06455.11 ACT04411.1 - 4.1e-05 23.2 0.1 4.1e-05 23.2 0.1 3.6 2 1 1 3 3 3 1 NADH dehydrogenase subunit 5 C-terminus Oxidored_q2 PF00420.24 ACT04412.1 - 2.6e-26 91.3 6.9 3e-26 91.1 6.9 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Oxidored_q3 PF00499.20 ACT04413.1 - 6.9e-36 123.1 13.4 6.9e-36 123.1 13.4 1.3 2 0 0 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF4040 PF13244.6 ACT04413.1 - 0.0016 18.6 13.9 0.0016 18.6 13.9 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4040) MFS_1 PF07690.16 ACT04413.1 - 0.062 12.2 12.8 0.04 12.8 8.0 2.0 2 0 0 2 2 2 0 Major Facilitator Superfamily TssN PF17555.2 ACT04413.1 - 0.22 10.9 8.4 0.37 10.2 8.4 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssN DUF948 PF06103.11 ACT04413.1 - 3 8.1 6.9 0.35 11.2 0.2 2.7 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF998 PF06197.13 ACT04413.1 - 3.5 7.2 19.2 0.84 9.2 13.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF998) Fer4 PF00037.27 ACT04414.1 - 3.8e-13 48.7 16.1 1.1e-06 28.2 2.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 ACT04414.1 - 1.2e-10 42.2 5.8 6.8e-05 23.7 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_7 PF12838.7 ACT04414.1 - 7.6e-10 39.2 9.9 1.1e-09 38.7 9.9 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 ACT04414.1 - 1.2e-08 34.9 10.9 0.00033 20.7 2.8 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 ACT04414.1 - 5.7e-08 32.5 19.8 0.00059 19.8 7.7 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 ACT04414.1 - 4.9e-07 29.8 10.1 2.6e-05 24.3 12.7 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 ACT04414.1 - 1.1e-06 29.1 3.2 0.022 15.3 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 ACT04414.1 - 2.1e-06 27.5 10.3 0.0015 18.5 1.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 ACT04414.1 - 8e-06 25.9 14.4 0.0016 18.5 15.7 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 ACT04414.1 - 5.9e-05 23.4 7.8 0.0088 16.5 11.4 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_4 PF12800.7 ACT04414.1 - 0.0012 19.2 14.0 0.065 13.8 1.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_22 PF17179.4 ACT04414.1 - 0.0042 17.9 7.5 0.45 11.4 1.5 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 ACT04414.1 - 0.014 16.3 3.0 0.014 16.3 3.0 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 ACT04414.1 - 0.55 10.5 15.0 0.44 10.7 2.0 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 ACT04414.1 - 0.78 10.0 3.2 2.8 8.2 0.0 2.1 2 0 0 2 2 2 0 c-SKI Smad4 binding domain Fer4_13 PF13370.6 ACT04414.1 - 3.2 8.3 15.8 2.3 8.9 1.7 2.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I NADHdh PF00146.21 ACT04415.1 - 1.8e-126 421.5 20.4 2.2e-126 421.2 20.4 1.0 1 0 0 1 1 1 1 NADH dehydrogenase CRPA PF05745.11 ACT04415.1 - 0.025 14.6 1.5 0.025 14.6 1.5 1.9 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Oxidored_q6 PF01058.22 ACT04416.1 - 5.8e-25 87.6 0.1 7.6e-25 87.2 0.1 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Oxidored_q4 PF00507.19 ACT04417.1 - 7.9e-37 125.4 1.1 7.9e-37 125.4 1.1 1.8 1 1 1 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 DUF2545 PF10810.8 ACT04417.1 - 2.6 8.2 9.1 1.5 9.0 4.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2545) MCPsignal PF00015.21 ACT04418.1 - 9.3e-34 116.7 29.9 6.2e-32 110.8 16.4 3.5 1 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 ACT04418.1 - 8.2e-10 38.9 0.1 1.3e-08 35.0 0.0 2.7 3 0 0 3 3 3 1 Cache domain HAMP PF00672.25 ACT04418.1 - 0.0018 18.6 1.4 0.0053 17.1 0.3 2.6 2 0 0 2 2 1 1 HAMP domain DUF948 PF06103.11 ACT04418.1 - 0.0022 18.2 22.4 1.8 8.9 3.2 5.0 2 2 2 4 4 4 4 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 ACT04418.1 - 0.0034 17.8 2.8 0.97 9.9 0.1 3.7 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein ORF6C PF10552.9 ACT04418.1 - 0.024 14.7 0.7 0.09 12.9 0.7 2.0 1 0 0 1 1 1 0 ORF6C domain FA_desaturase PF00487.24 ACT04418.1 - 0.35 10.7 0.9 0.75 9.6 0.9 1.5 1 0 0 1 1 1 0 Fatty acid desaturase RPW8 PF05659.11 ACT04418.1 - 0.49 10.1 7.0 7.7 6.2 0.1 3.9 2 1 2 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Csm2_III-A PF03750.13 ACT04418.1 - 0.55 11.1 4.8 2.3 9.1 0.2 3.4 4 0 0 4 4 3 0 Csm2 Type III-A Fib_alpha PF08702.10 ACT04418.1 - 3.7 7.7 14.7 21 5.3 1.3 4.1 2 2 1 4 4 4 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.12 ACT04418.1 - 3.9 7.5 21.3 5.3 7.1 0.3 4.6 3 2 2 5 5 5 0 Laminin Domain II DUF2205 PF10224.9 ACT04418.1 - 8.8 6.4 7.0 4.1 7.5 0.1 3.9 4 2 1 5 5 4 0 Short coiled-coil protein FecCD PF01032.18 ACT04419.1 - 4.3e-172 571.2 73.5 1.6e-90 303.3 33.2 2.0 2 0 0 2 2 2 2 FecCD transport family Peripla_BP_2 PF01497.18 ACT04420.1 - 1.6e-32 112.9 0.8 2.3e-32 112.5 0.8 1.2 1 0 0 1 1 1 1 Periplasmic binding protein DUF2514 PF10721.9 ACT04420.1 - 0.026 14.6 1.2 0.65 10.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) COX4_pro_2 PF07835.12 ACT04420.1 - 2 8.6 4.7 0.96 9.6 1.9 2.0 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV ATP-synt_DE_N PF02823.16 ACT04422.1 - 7e-28 96.4 0.3 9.5e-28 95.9 0.3 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ATP-synt_DE PF00401.20 ACT04422.1 - 7.6e-16 58.1 12.0 1.1e-15 57.6 12.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, long alpha-helix domain ATP-synt_ab PF00006.25 ACT04423.1 - 6.4e-67 225.3 0.0 9e-67 224.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ACT04423.1 - 2.4e-21 76.0 1.9 5.2e-21 74.9 1.9 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RsgA_GTPase PF03193.16 ACT04423.1 - 0.0038 17.1 0.0 0.0071 16.3 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase T3SS_ATPase_C PF18269.1 ACT04423.1 - 0.0081 16.0 0.3 0.032 14.1 0.3 2.0 1 1 0 1 1 1 1 T3SS EscN ATPase C-terminal domain AAA_19 PF13245.6 ACT04423.1 - 0.014 15.8 0.3 0.035 14.4 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 ACT04423.1 - 0.015 15.7 0.0 0.21 12.0 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 ACT04423.1 - 0.031 13.6 0.5 0.056 12.8 0.5 1.4 1 0 0 1 1 1 0 KaiC ABC_tran PF00005.27 ACT04423.1 - 0.046 14.2 0.0 0.12 12.9 0.0 1.7 1 0 0 1 1 1 0 ABC transporter TrwB_AAD_bind PF10412.9 ACT04423.1 - 0.061 12.2 0.1 0.099 11.5 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_7 PF12775.7 ACT04423.1 - 0.089 12.3 0.2 0.24 10.9 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase_2 PF01637.18 ACT04423.1 - 0.11 12.4 0.0 0.43 10.5 0.0 2.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 ACT04423.1 - 0.14 11.9 0.1 0.26 11.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain ATP-synt PF00231.19 ACT04424.1 - 4.3e-102 341.6 1.6 5.2e-102 341.3 1.6 1.0 1 0 0 1 1 1 1 ATP synthase ATP-synt_ab PF00006.25 ACT04425.1 - 3.4e-71 239.3 0.0 5.2e-71 238.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 ACT04425.1 - 2.9e-47 160.1 0.1 5.5e-47 159.2 0.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 ACT04425.1 - 7.9e-19 67.9 5.5 1.2e-18 67.4 4.4 2.0 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 ACT04425.1 - 0.00011 21.7 0.3 0.00011 21.7 0.3 2.4 3 0 0 3 3 3 1 KaiC HAS-barrel PF09378.10 ACT04425.1 - 0.00066 19.8 2.2 0.0039 17.3 1.4 2.5 2 0 0 2 2 2 1 HAS barrel domain Pdase_M17_N2 PF18295.1 ACT04425.1 - 0.16 12.2 0.0 0.49 10.6 0.0 1.8 1 0 0 1 1 1 0 M17 aminopeptidase N-terminal domain 2 OSCP PF00213.18 ACT04426.1 - 5.3e-44 150.4 0.7 5.9e-44 150.2 0.7 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit IRK_N PF08466.10 ACT04426.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Inward rectifier potassium channel N-terminal ATP-synt_B PF00430.18 ACT04427.1 - 6.4e-36 123.3 17.0 8.1e-36 123.0 17.0 1.1 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) DUF3584 PF12128.8 ACT04427.1 - 0.0012 16.5 16.8 0.0013 16.4 16.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) HrpE PF06188.12 ACT04427.1 - 0.0072 16.2 9.8 0.011 15.6 9.8 1.4 1 0 0 1 1 1 1 HrpE/YscL/FliH and V-type ATPase subunit E PEP-utilisers_N PF05524.13 ACT04427.1 - 0.018 15.2 9.5 0.026 14.7 9.3 1.4 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal DUF4378 PF14309.6 ACT04427.1 - 0.037 14.4 0.9 0.052 13.9 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4378) DUF2232 PF09991.9 ACT04427.1 - 0.079 12.1 0.5 0.15 11.2 0.5 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) TetR_C_23 PF17931.1 ACT04427.1 - 0.12 12.6 8.4 0.034 14.2 4.3 1.9 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF4736 PF15883.5 ACT04427.1 - 0.15 11.8 4.2 0.25 11.1 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) PIN_8 PF18476.1 ACT04427.1 - 0.17 11.7 8.7 0.2 11.5 8.7 1.1 1 0 0 1 1 1 0 PIN like domain NEMP PF10225.9 ACT04427.1 - 0.28 10.8 2.4 0.48 10.1 2.4 1.6 1 1 0 1 1 1 0 NEMP family ThiD2 PF17792.1 ACT04427.1 - 0.34 11.4 8.1 0.44 11.0 7.8 1.3 1 1 0 1 1 1 0 ThiD2 family DUF1414 PF07208.11 ACT04427.1 - 0.51 10.4 4.7 2.3 8.2 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1414) O-antigen_lig PF13425.6 ACT04427.1 - 0.64 8.7 5.7 0.25 10.1 3.6 1.3 1 1 1 2 2 2 0 O-antigen ligase like membrane protein Borrelia_P83 PF05262.11 ACT04427.1 - 3.2 6.1 20.9 3.8 5.9 20.9 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF2570 PF10828.8 ACT04427.1 - 5.4 6.9 18.2 2.1 8.2 13.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) NBD_C PF17042.5 ACT04427.1 - 7.7 7.0 11.3 10 6.6 11.3 1.2 1 0 0 1 1 1 0 Nucleotide-binding C-terminal domain ATP-synt_C PF00137.21 ACT04428.1 - 2.2e-13 50.3 7.3 2.8e-13 50.0 7.3 1.1 1 0 0 1 1 1 1 ATP synthase subunit C ATP-synt_A PF00119.20 ACT04429.1 - 4.4e-54 183.6 13.1 5.4e-54 183.4 13.1 1.0 1 0 0 1 1 1 1 ATP synthase A chain Gate PF07670.14 ACT04429.1 - 0.11 12.8 11.1 0.049 13.9 2.3 2.2 2 0 0 2 2 2 0 Nucleoside recognition ATP-synt_I PF03899.15 ACT04430.1 - 6e-06 26.6 8.3 9.5e-06 25.9 8.3 1.3 1 0 0 1 1 1 1 ATP synthase I chain DUF2530 PF10745.9 ACT04430.1 - 2.2 8.6 7.4 8 6.8 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) ATPase_gene1 PF09527.10 ACT04431.1 - 1.5e-07 31.5 8.4 2.1e-07 31.0 8.4 1.2 1 0 0 1 1 1 1 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Phage_holin_2_1 PF04971.12 ACT04431.1 - 0.00039 20.4 3.0 0.0058 16.6 1.8 2.1 1 1 1 2 2 2 2 Bacteriophage P21 holin S DUF2273 PF10031.9 ACT04431.1 - 0.039 14.0 7.9 2.1 8.4 0.1 2.4 2 0 0 2 2 2 0 Small integral membrane protein (DUF2273) Adeno_E3_CR2 PF02439.15 ACT04431.1 - 2.1 8.2 5.4 3.1 7.6 5.4 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Epimerase_2 PF02350.19 ACT04432.1 - 5.3e-113 377.4 0.0 6.7e-113 377.1 0.0 1.1 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase Glyco_trans_4_2 PF13477.6 ACT04432.1 - 0.07 13.2 0.0 2.7 8.0 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase 4-like UPRTase PF14681.6 ACT04433.1 - 2.9e-73 245.7 0.1 3.3e-73 245.5 0.1 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ACT04433.1 - 2.5e-09 36.9 0.0 3.8e-09 36.3 0.0 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain ABC_tran PF00005.27 ACT04434.1 - 7.8e-34 117.1 0.0 1.1e-33 116.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 ACT04434.1 - 6.7e-17 61.8 0.3 1.2e-16 60.9 0.3 1.5 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region SMC_N PF02463.19 ACT04434.1 - 0.00037 20.0 0.0 0.00064 19.2 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT04434.1 - 0.0096 16.2 0.1 0.023 15.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ACT04434.1 - 0.019 15.3 0.1 0.037 14.4 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 ACT04434.1 - 0.023 13.8 0.0 0.026 13.7 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_21 PF13304.6 ACT04434.1 - 0.025 14.4 0.1 2.1 8.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system PRK PF00485.18 ACT04434.1 - 0.061 13.1 0.1 0.12 12.1 0.1 1.5 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ATP-synt_ab PF00006.25 ACT04434.1 - 0.11 12.1 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 ACT04434.1 - 0.13 12.6 0.0 0.37 11.2 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ACT04434.1 - 0.15 11.7 0.1 1.4 8.6 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_13 PF13166.6 ACT04434.1 - 0.17 10.5 0.1 0.25 10.0 0.1 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ACT04435.1 - 3.1e-29 102.2 0.0 4.2e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 ACT04435.1 - 1.6e-18 67.0 1.3 1.8e-18 66.8 0.1 1.8 2 0 0 2 2 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 ACT04435.1 - 1.2e-07 31.8 0.0 1.1e-06 28.7 0.0 2.0 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ACT04435.1 - 8e-05 22.9 0.4 0.002 18.4 0.4 2.2 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ACT04435.1 - 0.00013 21.5 0.1 0.00022 20.8 0.1 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region SMC_N PF02463.19 ACT04435.1 - 0.0015 18.0 0.1 0.0076 15.7 0.1 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACT04435.1 - 0.0028 18.1 0.0 0.0037 17.7 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 ACT04435.1 - 0.0045 16.7 0.1 0.14 11.8 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain TniB PF05621.11 ACT04435.1 - 0.0074 15.7 0.1 0.65 9.4 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein AAA PF00004.29 ACT04435.1 - 0.012 16.0 0.5 0.27 11.7 0.5 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 ACT04435.1 - 0.013 15.3 0.2 0.086 12.6 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein ABC_ATPase PF09818.9 ACT04435.1 - 0.032 13.0 0.3 0.17 10.7 0.3 2.0 1 1 0 1 1 1 0 Predicted ATPase of the ABC class ATP-synt_ab PF00006.25 ACT04435.1 - 0.036 13.7 0.2 0.077 12.6 0.1 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Mg_chelatase PF01078.21 ACT04435.1 - 0.05 13.0 0.1 0.13 11.6 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 ACT04435.1 - 0.06 13.7 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 ACT04435.1 - 0.08 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 ACT04435.1 - 0.09 12.5 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 ACT04435.1 - 0.097 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 ACT04435.1 - 0.1 12.7 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain BPD_transp_1 PF00528.22 ACT04436.1 - 1.4e-33 116.2 19.2 5.1e-33 114.4 12.7 2.1 2 0 0 2 2 2 2 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 ACT04436.1 - 1.9e-16 59.7 0.8 1.9e-16 59.7 0.8 2.9 3 1 0 3 3 3 1 N-terminal TM domain of oligopeptide transport permease C BPD_transp_1 PF00528.22 ACT04437.1 - 4.9e-40 137.2 15.5 4.9e-40 137.2 15.5 2.0 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Renin_r PF07850.14 ACT04437.1 - 1.7 9.3 3.7 8.2 7.1 0.1 2.6 2 0 0 2 2 2 0 Renin receptor-like protein SBP_bac_5 PF00496.22 ACT04438.1 - 7e-90 301.7 16.3 8.6e-90 301.4 16.3 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle N_methyl PF07963.12 ACT04438.1 - 0.0019 17.7 0.2 0.0037 16.8 0.2 1.4 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif SHMT PF00464.19 ACT04439.1 - 7.1e-173 574.8 0.1 9.8e-173 574.3 0.1 1.2 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 ACT04439.1 - 6.2e-08 32.2 0.0 9.7e-08 31.6 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ACT04439.1 - 0.0014 18.0 0.0 0.0052 16.1 0.1 1.8 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ACT04439.1 - 0.0022 17.0 0.0 0.0055 15.7 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ACT04439.1 - 0.0051 16.2 0.3 0.0073 15.7 0.3 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ACT04439.1 - 0.0055 15.3 0.0 0.0082 14.7 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF436 PF04260.12 ACT04440.1 - 5.4e-71 237.7 0.4 6.2e-71 237.5 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF436) LacAB_rpiB PF02502.18 ACT04441.1 - 9.1e-58 194.2 0.0 1e-57 194.0 0.0 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase LMWPc PF01451.21 ACT04442.1 - 1e-27 97.3 0.0 1.6e-23 83.7 0.0 2.0 1 1 1 2 2 2 2 Low molecular weight phosphotyrosine protein phosphatase PTS_IIB PF02302.17 ACT04442.1 - 0.017 15.8 0.2 0.46 11.2 0.2 2.7 1 1 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIB subunit Com_YlbF PF06133.11 ACT04442.1 - 0.033 14.8 2.6 0.057 14.0 2.6 1.4 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA Mntp PF02659.15 ACT04443.1 - 4.5e-38 130.4 23.6 2.9e-36 124.5 15.8 2.0 1 1 1 2 2 2 2 Putative manganese efflux pump Sua5_yciO_yrdC PF01300.18 ACT04444.1 - 1.7e-55 187.3 0.0 2.3e-55 186.8 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 ACT04444.1 - 1.3e-31 110.0 0.1 1.9e-31 109.4 0.1 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Spore_II_R PF09551.10 ACT04445.1 - 8e-48 162.1 0.1 2.1e-47 160.8 0.0 1.6 2 0 0 2 2 2 1 Stage II sporulation protein R (spore_II_R) TetR_C_20 PF17925.1 ACT04445.1 - 0.46 10.8 3.2 0.24 11.7 0.3 2.0 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain PrmC_N PF17827.1 ACT04446.1 - 2.8e-12 47.0 0.1 1.1e-11 45.1 0.0 2.0 2 0 0 2 2 2 1 PrmC N-terminal domain MTS PF05175.14 ACT04446.1 - 7.5e-11 41.9 0.1 4.5e-10 39.3 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ACT04446.1 - 3.4e-09 37.3 0.0 2.9e-08 34.3 0.0 2.4 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT04446.1 - 8.4e-09 35.4 0.0 1.5e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ACT04446.1 - 5.8e-05 22.5 0.0 9.5e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_18 PF12847.7 ACT04446.1 - 0.0001 22.2 0.0 0.00016 21.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT04446.1 - 0.00013 22.6 0.0 0.00029 21.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT04446.1 - 0.00016 22.2 0.0 0.00048 20.7 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 ACT04446.1 - 0.00093 18.7 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 ACT04446.1 - 0.0013 18.4 0.0 0.0017 17.9 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_32 PF13679.6 ACT04446.1 - 0.002 18.1 0.0 0.0035 17.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 ACT04446.1 - 0.002 17.9 0.0 0.0033 17.2 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase UPF0020 PF01170.18 ACT04446.1 - 0.016 14.9 0.0 0.046 13.4 0.0 1.6 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Ubie_methyltran PF01209.18 ACT04446.1 - 0.036 13.4 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 ACT04446.1 - 0.059 12.8 0.0 0.094 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase GidB PF02527.15 ACT04446.1 - 0.092 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 ACT04446.1 - 0.1 12.4 0.0 0.15 11.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_10 PF05971.12 ACT04446.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 RNA methyltransferase Met_10 PF02475.16 ACT04446.1 - 0.15 11.8 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein PCRF PF03462.18 ACT04447.1 - 4.7e-70 235.4 0.3 4.7e-70 235.4 0.3 1.5 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 ACT04447.1 - 8.3e-37 125.7 0.9 8.3e-37 125.7 0.9 2.0 2 1 0 2 2 2 1 RF-1 domain ABC_tran_CTD PF16326.5 ACT04447.1 - 0.00021 21.4 0.6 0.00021 21.4 0.6 3.6 2 1 1 3 3 3 1 ABC transporter C-terminal domain OSCP PF00213.18 ACT04447.1 - 0.02 15.0 1.6 0.072 13.2 1.3 1.9 1 1 1 2 2 2 0 ATP synthase delta (OSCP) subunit V_ATPase_I PF01496.19 ACT04447.1 - 0.043 11.7 0.8 0.075 11.0 0.8 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.9 ACT04447.1 - 0.56 9.2 3.7 1.1 8.3 0.8 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 CHD5 PF04420.14 ACT04447.1 - 0.61 9.9 2.3 8.2 6.3 0.1 2.2 2 0 0 2 2 2 0 CHD5-like protein DUF1775 PF07987.11 ACT04448.1 - 9e-24 84.4 4.2 2e-23 83.3 4.2 1.6 1 1 0 1 1 1 1 Domain of unkown function (DUF1775) DUF4064 PF13273.6 ACT04448.1 - 0.073 13.4 0.1 0.3 11.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) CopC PF04234.12 ACT04449.1 - 2.2e-20 73.5 0.0 5.6e-20 72.2 0.0 1.7 2 0 0 2 2 2 1 CopC domain CopD PF05425.13 ACT04449.1 - 9.7e-06 25.9 15.4 9.7e-06 25.9 15.4 4.2 3 2 1 4 4 4 1 Copper resistance protein D YchF-GTPase_C PF06071.13 ACT04450.1 - 1.4e-40 137.3 0.1 2.8e-40 136.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 ACT04450.1 - 1.2e-24 86.6 0.1 2.8e-24 85.4 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ACT04450.1 - 1.2e-09 37.9 1.2 2.3e-08 33.7 0.0 2.8 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ACT04450.1 - 0.093 12.8 0.2 13 5.8 0.0 3.0 1 1 2 3 3 3 0 Dynamin family AAA_23 PF13476.6 ACT04450.1 - 0.12 12.9 0.5 15 6.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain Methyltransf_11 PF08241.12 ACT04451.1 - 1.9e-29 102.1 0.1 2.5e-23 82.5 0.0 2.8 3 0 0 3 3 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ACT04451.1 - 7.7e-27 93.8 0.1 7.1e-20 71.5 0.0 2.9 3 0 0 3 3 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 ACT04451.1 - 7.5e-24 84.4 0.0 7e-15 55.2 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 ACT04451.1 - 1.1e-21 77.2 0.0 1.1e-18 67.5 0.0 2.6 2 1 0 2 2 2 2 Methyltransferase domain Glycos_transf_2 PF00535.26 ACT04451.1 - 7.1e-19 68.2 0.0 1.3e-18 67.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Methyltransf_12 PF08242.12 ACT04451.1 - 3.9e-14 53.2 0.0 2.9e-10 40.8 0.0 2.9 2 1 0 2 2 2 2 Methyltransferase domain Glyco_tranf_2_3 PF13641.6 ACT04451.1 - 3.6e-11 43.4 0.0 6.9e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Ubie_methyltran PF01209.18 ACT04451.1 - 5.5e-09 35.7 0.0 1.2e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 ACT04451.1 - 1e-07 31.6 0.0 5.6e-05 22.8 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase small domain MetW PF07021.12 ACT04451.1 - 7.5e-06 25.7 0.0 0.0088 15.6 0.0 2.2 2 0 0 2 2 2 2 Methionine biosynthesis protein MetW Glyco_trans_2_3 PF13632.6 ACT04451.1 - 1.5e-05 25.0 0.0 2.4e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_2 PF10111.9 ACT04451.1 - 2.2e-05 24.1 0.0 7.8e-05 22.3 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ACT04451.1 - 3e-05 23.6 0.0 8.3e-05 22.1 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 21 CMAS PF02353.20 ACT04451.1 - 6.9e-05 22.3 0.0 0.00069 19.0 0.0 2.0 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Glyco_transf_7C PF02709.14 ACT04451.1 - 0.0014 18.2 0.0 0.0034 17.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Methyltransf_29 PF03141.16 ACT04451.1 - 0.0025 16.5 0.0 0.0039 15.8 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Glyco_tranf_2_4 PF13704.6 ACT04451.1 - 0.011 16.2 0.0 0.032 14.7 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferase family 2 Methyltransf_8 PF05148.15 ACT04451.1 - 0.057 13.3 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase PrmA PF06325.13 ACT04451.1 - 0.057 12.8 0.0 0.12 11.7 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 ACT04451.1 - 0.063 12.7 0.1 1.3 8.4 0.0 2.5 3 0 0 3 3 3 0 Tellurite resistance protein TehB Methyltransf_4 PF02390.17 ACT04451.1 - 0.082 12.4 0.0 0.24 10.9 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase Pox_MCEL PF03291.16 ACT04451.1 - 0.14 11.2 0.0 2.4 7.2 0.1 2.5 3 1 1 4 4 4 0 mRNA capping enzyme Methyltransf_32 PF13679.6 ACT04451.1 - 0.17 11.9 0.2 0.69 9.9 0.1 1.9 2 0 0 2 2 2 0 Methyltransferase domain SLH PF00395.20 ACT04454.1 - 1.9e-16 59.8 0.3 3.4e-05 23.8 0.0 3.9 3 0 0 3 3 3 3 S-layer homology domain PepSY PF03413.19 ACT04454.1 - 4.1e-08 33.7 10.6 0.01 16.4 0.0 5.4 6 1 0 6 6 6 3 Peptidase propeptide and YPEB domain PQQ PF01011.21 ACT04454.1 - 0.019 14.9 0.3 4.1 7.5 0.0 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat BPD_transp_1 PF00528.22 ACT04455.1 - 6.5e-12 45.6 12.3 6.5e-12 45.6 12.3 2.5 1 1 1 3 3 3 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04456.1 - 2.8e-15 56.6 11.8 2.8e-15 56.6 11.8 1.8 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component MNHE PF01899.16 ACT04456.1 - 0.099 12.4 1.2 0.25 11.1 1.2 1.6 1 0 0 1 1 1 0 Na+/H+ ion antiporter subunit SBP_bac_1 PF01547.25 ACT04457.1 - 1.8e-16 61.0 10.7 3.1e-16 60.2 10.7 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT04457.1 - 5.6e-12 46.1 4.8 6.8e-12 45.8 3.8 1.6 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein DUF3502 PF12010.8 ACT04457.1 - 0.00026 21.7 0.2 0.00063 20.4 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) HTH_18 PF12833.7 ACT04458.1 - 3.9e-22 78.3 0.0 1.2e-21 76.8 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04458.1 - 1.1e-12 47.6 0.0 3.1e-06 27.1 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family dCache_1 PF02743.18 ACT04458.1 - 1.7e-12 47.6 0.3 6.7e-12 45.7 0.4 1.9 2 0 0 2 2 2 1 Cache domain GGDEF_2 PF17853.1 ACT04458.1 - 5.8e-05 23.3 0.0 0.00026 21.2 0.0 2.1 2 0 0 2 2 2 1 GGDEF-like domain Prominin PF05478.11 ACT04458.1 - 0.11 10.4 0.1 0.37 8.7 0.0 1.7 2 0 0 2 2 2 0 Prominin GFO_IDH_MocA PF01408.22 ACT04459.1 - 6e-20 72.3 0.0 1.3e-19 71.2 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ACT04459.1 - 1.7e-13 50.6 0.1 2.9e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Sacchrp_dh_NADP PF03435.18 ACT04459.1 - 0.00049 20.3 0.0 0.0013 18.9 0.0 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 ACT04459.1 - 0.00055 20.5 0.0 0.0013 19.3 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 ACT04459.1 - 0.0035 17.6 0.0 0.0062 16.8 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.15 ACT04459.1 - 0.0045 17.2 0.0 0.0086 16.3 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Semialdhyde_dh PF01118.24 ACT04459.1 - 0.016 15.7 0.0 0.028 14.8 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain ProRS-C_2 PF09181.10 ACT04459.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Prolyl-tRNA synthetase, C-terminal 2-Hacid_dh_C PF02826.19 ACT04459.1 - 0.16 11.3 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PGM1_C PF18105.1 ACT04459.1 - 0.18 11.3 0.1 0.51 9.9 0.1 1.7 1 0 0 1 1 1 0 PGM1 C-terminal domain AP_endonuc_2 PF01261.24 ACT04460.1 - 2.1e-21 76.3 0.1 3.1e-21 75.8 0.1 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel UxuA PF03786.13 ACT04460.1 - 0.0027 16.6 0.0 0.0079 15.1 0.0 1.6 2 0 0 2 2 2 1 D-mannonate dehydratase (UxuA) NitrOD2 PF18550.1 ACT04460.1 - 0.035 14.2 0.1 0.25 11.5 0.0 2.2 2 0 0 2 2 2 0 Nitrososphaera output domain 2 NBD94 PF16830.5 ACT04460.1 - 0.13 12.7 0.7 0.27 11.7 0.7 1.4 1 0 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH HTH_18 PF12833.7 ACT04461.1 - 1.2e-15 57.5 2.9 1.7e-15 57.0 0.7 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain AraC_binding PF02311.19 ACT04461.1 - 9.6e-13 48.2 0.3 1.6e-12 47.5 0.3 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain HTH_AraC PF00165.23 ACT04461.1 - 5.3e-09 35.9 0.4 0.00064 19.8 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cupin_2 PF07883.11 ACT04461.1 - 1.5e-05 24.6 0.1 3.2e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Cupin domain Pec_lyase_C PF00544.19 ACT04461.1 - 0.022 14.4 0.1 0.033 13.8 0.1 1.3 1 0 0 1 1 1 0 Pectate lyase Thioredoxin PF00085.20 ACT04462.1 - 7.1e-31 106.3 0.0 7.7e-31 106.2 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ACT04462.1 - 9.1e-08 32.5 0.2 1e-06 29.1 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ACT04462.1 - 6.2e-07 29.7 0.0 0.0017 18.6 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_9 PF14595.6 ACT04462.1 - 3.6e-06 26.8 0.0 4.3e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 ACT04462.1 - 3.7e-06 26.9 0.0 4.1e-06 26.8 0.0 1.0 1 0 0 1 1 1 1 F plasmid transfer operon protein KaiB PF07689.12 ACT04462.1 - 1.2e-05 24.9 0.1 1.6e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 KaiB domain Thioredoxin_3 PF13192.6 ACT04462.1 - 2.2e-05 24.4 0.0 2.9e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Redoxin PF08534.10 ACT04462.1 - 3.5e-05 23.5 0.0 4.3e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ACT04462.1 - 4.5e-05 23.4 0.0 5.4e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family HyaE PF07449.11 ACT04462.1 - 0.00021 21.2 0.0 0.00026 20.9 0.0 1.1 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 ACT04462.1 - 0.025 14.8 0.0 0.04 14.1 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin TrbC_Ftype PF09673.10 ACT04462.1 - 0.029 14.4 0.0 0.035 14.2 0.0 1.1 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein OST3_OST6 PF04756.13 ACT04462.1 - 0.033 13.6 0.0 0.037 13.4 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 ACT04462.1 - 0.079 12.9 0.0 0.08 12.8 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain DUF836 PF05768.14 ACT04462.1 - 0.13 12.7 0.0 0.17 12.3 0.0 1.2 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Rrf2 PF02082.20 ACT04463.1 - 2.3e-21 75.9 0.0 4.1e-21 75.1 0.0 1.4 2 0 0 2 2 2 1 Transcriptional regulator HrcA_DNA-bdg PF03444.15 ACT04463.1 - 3.1e-06 26.8 0.0 4.8e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding TrmB PF01978.19 ACT04463.1 - 0.00084 19.2 0.0 0.0016 18.3 0.0 1.5 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Put_DNA-bind_N PF06971.13 ACT04463.1 - 0.062 13.3 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative DNA-binding protein N-terminus FAST_1 PF06743.15 ACT04463.1 - 0.089 12.8 0.0 16 5.5 0.0 2.2 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 HTH_Crp_2 PF13545.6 ACT04463.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Dimer_Tnp_Tn5 PF02281.16 ACT04463.1 - 0.19 11.5 0.0 0.31 10.8 0.0 1.4 1 1 0 1 1 1 0 Transposase Tn5 dimerisation domain SWIB PF02201.18 ACT04464.1 - 0.033 14.1 0.0 0.04 13.8 0.0 1.2 1 0 0 1 1 1 0 SWIB/MDM2 domain Peptidase_S66 PF02016.15 ACT04464.1 - 0.06 13.4 0.1 0.063 13.4 0.1 1.1 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain Multi_Drug_Res PF00893.19 ACT04465.1 - 6e-20 71.7 8.0 9.3e-20 71.1 8.0 1.2 1 0 0 1 1 1 1 Small Multidrug Resistance protein Multi_Drug_Res PF00893.19 ACT04466.1 - 4.2e-26 91.4 7.4 5e-26 91.2 7.4 1.1 1 0 0 1 1 1 1 Small Multidrug Resistance protein Bax1-I PF01027.20 ACT04466.1 - 0.018 14.9 9.4 0.021 14.7 9.4 1.1 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 DUF3325 PF11804.8 ACT04466.1 - 0.044 13.9 2.0 0.068 13.3 2.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3325) ThrE PF06738.12 ACT04466.1 - 0.15 11.4 6.6 0.69 9.2 1.5 2.0 1 1 1 2 2 2 0 Putative threonine/serine exporter RNase_J_C PF17770.1 ACT04467.1 - 6.4e-29 100.8 0.1 1.2e-28 99.9 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease J C-terminal domain Lactamase_B PF00753.27 ACT04467.1 - 1.3e-15 58.0 0.4 4.6e-15 56.1 0.5 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 ACT04467.1 - 1.3e-11 44.2 0.2 1.2e-10 41.1 0.0 2.4 3 0 0 3 3 3 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 ACT04467.1 - 1.9e-11 43.9 0.3 1.1e-10 41.4 0.1 2.3 2 1 1 3 3 3 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ACT04467.1 - 0.031 14.2 0.1 0.19 11.6 0.0 2.2 2 0 0 2 2 2 0 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 ACT04467.1 - 0.1 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain DUF2981 PF11200.8 ACT04468.1 - 0.027 14.2 0.9 0.027 14.2 0.9 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2981) DUF805 PF05656.14 ACT04468.1 - 0.038 14.4 0.8 0.038 14.4 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF805) Claudin_2 PF13903.6 ACT04468.1 - 0.77 9.5 7.9 0.057 13.2 0.8 2.0 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF2070 PF09843.9 ACT04468.1 - 4 5.6 8.7 4.6 5.4 8.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) S_2TMBeta PF18153.1 ACT04468.1 - 5.2 6.8 6.7 7.3 6.3 6.7 1.1 1 0 0 1 1 1 0 SMODS-associating 2TM, beta-strand rich effector domain Aminotran_1_2 PF00155.21 ACT04469.1 - 7.2e-56 189.9 0.0 8.1e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Acetyltransf_1 PF00583.25 ACT04470.1 - 5.1e-13 49.3 0.0 6e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 ACT04470.1 - 7.8e-13 48.8 0.0 8.4e-13 48.7 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACT04470.1 - 2.8e-10 41.0 0.0 3.2e-10 40.8 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT04470.1 - 4.5e-07 30.2 0.0 6.5e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT04470.1 - 0.099 12.6 0.0 0.19 11.7 0.0 1.6 1 1 0 1 1 1 0 FR47-like protein GNAT_acetyltran PF12746.7 ACT04470.1 - 0.18 11.4 0.0 0.33 10.5 0.0 1.4 1 1 0 1 1 1 0 GNAT acetyltransferase RDD PF06271.12 ACT04471.1 - 5.8e-23 81.7 5.6 5e-22 78.6 5.6 1.9 1 1 0 1 1 1 1 RDD family MgtE PF01769.16 ACT04471.1 - 0.0071 16.7 1.6 2.6 8.5 0.1 2.1 1 1 1 2 2 2 2 Divalent cation transporter Pilin_N PF07790.11 ACT04471.1 - 0.026 15.5 0.8 0.053 14.5 0.8 1.6 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal YitT_membrane PF02588.15 ACT04471.1 - 0.033 13.5 5.0 0.065 12.6 5.0 1.4 1 1 0 1 1 1 0 Uncharacterised 5xTM membrane BCR, YitT family COG1284 tRNA-synt_1c PF00749.21 ACT04472.1 - 1.9e-107 358.8 0.0 2.9e-107 358.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ACT04472.1 - 3.4e-58 196.4 0.0 6.4e-58 195.5 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain SNF PF00209.18 ACT04473.1 - 1.3e-52 179.2 36.7 2.6e-29 102.3 19.3 2.3 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family TPR_19 PF14559.6 ACT04474.1 - 0.0071 16.8 3.9 0.015 15.8 2.2 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ACT04474.1 - 0.034 14.4 2.7 0.11 12.7 0.2 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ACT04474.1 - 0.085 13.0 6.4 4.3 7.7 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ACT04474.1 - 3.3 7.9 6.3 43 4.5 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 ACT04474.1 - 3.4 8.0 12.7 22 5.4 0.6 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.26 ACT04475.1 - 7e-13 48.7 0.1 1.2e-12 47.9 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 ACT04475.1 - 2e-10 41.1 2.5 3.5e-10 40.3 0.5 2.3 2 1 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ACT04475.1 - 0.00028 20.8 0.0 0.00036 20.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ACT04475.1 - 0.0051 16.3 0.0 0.006 16.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_1 PF00534.20 ACT04476.1 - 3.2e-20 72.3 0.0 6.7e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT04476.1 - 1.3e-18 67.7 0.0 2.3e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ACT04476.1 - 5.7e-09 36.2 0.0 1.4e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ACT04476.1 - 1.8e-05 24.8 1.5 0.00032 20.8 0.5 2.8 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ACT04476.1 - 0.0084 16.6 0.4 0.42 11.0 0.1 2.8 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glycos_transf_2 PF00535.26 ACT04478.1 - 2.3e-12 47.0 0.0 4.3e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 ACT04478.1 - 5.4e-07 30.0 0.1 1.5e-06 28.6 0.1 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 2 TPR_14 PF13428.6 ACT04478.1 - 0.0002 21.9 2.2 0.0002 21.9 2.2 8.4 7 3 2 9 9 9 3 Tetratricopeptide repeat Glyco_tranf_2_3 PF13641.6 ACT04478.1 - 0.017 15.0 0.0 0.036 13.9 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase like family 2 TPR_2 PF07719.17 ACT04478.1 - 0.02 15.0 23.3 2.8 8.3 4.5 6.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 ACT04478.1 - 0.069 13.7 37.8 0.091 13.3 0.6 6.3 4 1 2 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 ACT04478.1 - 0.091 13.0 2.0 3.3 8.2 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 ACT04478.1 - 0.46 11.0 3.8 8.4 7.0 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 ACT04478.1 - 1.1 9.2 7.8 44 4.1 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.26 ACT04479.1 - 6.2e-26 91.2 0.0 1.3e-25 90.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 ACT04479.1 - 1.5e-08 35.0 0.0 1.1e-07 32.2 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 TPR_2 PF07719.17 ACT04479.1 - 1.9e-07 30.7 17.4 0.0061 16.6 0.1 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 ACT04479.1 - 4.6e-07 29.4 9.4 0.045 13.6 0.1 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ACT04479.1 - 1.3e-05 25.0 9.3 0.11 12.7 0.1 4.4 5 0 0 5 5 5 3 Tetratricopeptide repeat Glyco_tranf_2_3 PF13641.6 ACT04479.1 - 3.1e-05 24.0 0.0 5.1e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 TPR_17 PF13431.6 ACT04479.1 - 6.2e-05 23.1 0.6 0.23 11.9 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat Glyco_tranf_2_2 PF10111.9 ACT04479.1 - 8.2e-05 22.2 0.0 0.00014 21.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 TPR_16 PF13432.6 ACT04479.1 - 0.0018 18.9 9.3 0.5 11.1 3.4 3.9 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 ACT04479.1 - 0.011 16.0 0.5 0.038 14.3 0.1 2.1 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 ACT04479.1 - 0.019 15.5 9.6 0.18 12.3 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat PALP PF00291.25 ACT04479.1 - 0.063 12.7 0.1 0.27 10.6 0.0 2.0 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme ANAPC3 PF12895.7 ACT04479.1 - 0.069 13.4 5.3 6.1 7.2 0.9 3.0 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 ACT04479.1 - 0.1 12.9 16.6 0.2 11.9 2.1 4.7 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 ACT04479.1 - 0.89 10.5 23.2 4.8 8.3 0.1 7.2 3 2 5 8 8 8 0 Tetratricopeptide repeat TPR_6 PF13174.6 ACT04479.1 - 2.4 9.0 10.1 22 6.0 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.26 ACT04480.1 - 2.3e-19 69.9 0.1 4.6e-19 68.9 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 ACT04480.1 - 2e-10 41.0 0.0 6.4e-10 39.4 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 2 TPR_16 PF13432.6 ACT04480.1 - 1.2e-05 25.8 39.9 0.061 14.0 4.3 6.9 5 2 2 7 7 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ACT04480.1 - 2.2e-05 24.6 8.1 0.29 11.4 0.0 4.9 5 0 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ACT04480.1 - 0.00016 21.5 26.8 0.0086 16.1 0.0 6.9 7 0 0 7 7 6 2 Tetratricopeptide repeat Glyco_tranf_2_3 PF13641.6 ACT04480.1 - 0.00025 21.0 0.0 0.00065 19.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 TPR_9 PF13371.6 ACT04480.1 - 0.00028 21.0 8.8 0.014 15.6 0.0 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 ACT04480.1 - 0.0036 17.6 6.3 0.13 12.7 0.0 4.6 6 0 0 6 6 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ACT04480.1 - 0.0051 16.9 19.8 1.2 9.5 0.0 5.7 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 ACT04480.1 - 0.016 15.7 29.2 0.32 11.5 0.8 5.9 4 1 3 7 7 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 ACT04480.1 - 0.027 14.5 3.4 20 5.5 0.2 4.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 ACT04480.1 - 0.049 14.0 2.8 8.2 6.8 0.3 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ACT04480.1 - 0.11 12.8 25.4 0.89 9.9 0.0 6.7 5 3 2 7 7 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 ACT04480.1 - 0.22 11.4 17.7 0.64 9.9 0.3 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 ACT04480.1 - 1 9.0 9.6 2.5 7.8 0.2 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 ACT04480.1 - 1.7 8.6 0.0 1.7 8.6 0.0 5.5 7 0 0 7 7 6 0 Tetratricopeptide repeat TamB PF04357.13 ACT04482.1 - 0.00069 19.0 44.3 0.035 13.3 5.3 6.2 1 1 5 6 6 6 5 TamB, inner membrane protein subunit of TAM complex Ribosomal_L21p PF00829.21 ACT04482.1 - 0.71 10.2 16.2 33 4.8 0.3 6.2 4 2 3 7 7 7 0 Ribosomal prokaryotic L21 protein GSHPx PF00255.19 ACT04486.1 - 1.6e-39 133.8 0.2 2.2e-39 133.4 0.2 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 ACT04486.1 - 1.1e-09 38.3 0.1 6.7e-09 35.7 0.0 1.9 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 ACT04486.1 - 4.3e-05 23.3 0.0 0.0044 16.7 0.0 2.1 2 0 0 2 2 2 2 Redoxin DUF1453 PF07301.11 ACT04488.1 - 1.5e-50 171.0 10.4 1.7e-50 170.8 10.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1453) UPF0182 PF03699.13 ACT04488.1 - 0.22 9.6 3.1 0.26 9.4 3.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Dpy19 PF10034.9 ACT04488.1 - 0.26 9.5 7.3 0.35 9.0 7.3 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation Aldo_ket_red PF00248.21 ACT04489.1 - 1.9e-59 201.3 0.0 2.2e-59 201.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family BLACT_WH PF17778.1 ACT04489.1 - 0.072 13.1 0.4 0.2 11.7 0.0 1.9 2 0 0 2 2 2 0 Beta-lactamase associated winged helix domain DUF5516 PF17637.2 ACT04489.1 - 0.15 11.9 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5516) Catalase PF00199.19 ACT04490.1 - 6.5e-186 618.0 0.0 7.6e-186 617.8 0.0 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ACT04490.1 - 2.6e-17 62.8 0.0 6.2e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 Catalase-related immune-responsive Trans_reg_C PF00486.28 ACT04491.1 - 4.9e-26 90.6 0.0 8.9e-26 89.8 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal FUR PF01475.19 ACT04492.1 - 2.3e-28 98.8 0.3 2.5e-28 98.6 0.3 1.0 1 0 0 1 1 1 1 Ferric uptake regulator family Penicillinase_R PF03965.16 ACT04492.1 - 6.8e-05 23.2 0.0 8.4e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Penicillinase repressor PadR PF03551.14 ACT04492.1 - 0.0028 17.6 0.0 0.0044 17.0 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family TrmB PF01978.19 ACT04492.1 - 0.026 14.4 0.0 0.6 10.0 0.0 2.3 1 1 1 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 ACT04492.1 - 0.033 14.3 0.1 1.4 9.0 0.1 2.2 1 1 0 1 1 1 0 Helix-turn-helix domain TraI PF07057.11 ACT04492.1 - 0.1 12.7 0.1 1.5 9.0 0.0 2.1 1 1 1 2 2 2 0 DNA helicase TraI HTH_12 PF08461.10 ACT04492.1 - 0.1 12.5 0.1 0.32 11.0 0.1 1.8 1 1 0 1 1 1 0 Ribonuclease R winged-helix domain PLDc_2 PF13091.6 ACT04493.1 - 7.4e-43 145.6 0.0 1e-26 93.4 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ACT04493.1 - 5.1e-16 58.1 1.2 1.4e-07 31.4 0.3 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_N PF13396.6 ACT04493.1 - 4.1e-11 42.6 4.1 7.5e-11 41.8 4.1 1.5 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal DUF4131 PF13567.6 ACT04493.1 - 0.036 13.7 0.2 0.072 12.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) HD_assoc PF13286.6 ACT04494.1 - 8.5e-20 71.1 0.4 2e-18 66.7 0.1 2.7 2 1 0 2 2 2 1 Phosphohydrolase-associated domain HD PF01966.22 ACT04494.1 - 4.9e-14 52.6 0.1 1.3e-13 51.3 0.1 1.8 1 1 0 1 1 1 1 HD domain IU_nuc_hydro PF01156.19 ACT04495.1 - 5.3e-46 157.6 0.0 6.2e-46 157.4 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF1540 PF07561.11 ACT04496.1 - 5.2e-15 55.5 5.7 5.8e-15 55.3 5.7 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1540) VanY PF02557.17 ACT04497.1 - 3.8e-43 146.5 0.0 5.1e-43 146.0 0.0 1.2 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase PT PF04886.12 ACT04497.1 - 0.002 17.6 28.6 0.8 9.3 28.6 3.1 1 1 0 1 1 1 1 PT repeat DUF929 PF06053.11 ACT04497.1 - 0.043 13.1 0.0 3.5 6.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF929) Chordopox_A13L PF05961.11 ACT04497.1 - 0.071 13.4 0.0 0.32 11.2 0.0 2.1 2 0 0 2 2 2 0 Chordopoxvirus A13L protein SARAF PF06682.12 ACT04497.1 - 0.087 12.5 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2615 PF11027.8 ACT04497.1 - 0.1 12.8 0.0 0.1 12.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) DUF1244 PF06844.11 ACT04497.1 - 0.19 11.9 0.1 0.46 10.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) Herpes_DNAp_acc PF04929.12 ACT04497.1 - 2.3 7.1 6.1 3.2 6.7 6.1 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor MSA-2c PF12238.8 ACT04497.1 - 2.4 8.1 10.4 4.7 7.2 10.4 1.5 1 0 0 1 1 1 0 Merozoite surface antigen 2c Sulfatase PF00884.23 ACT04498.1 - 2.8e-42 145.2 0.1 3.6e-42 144.8 0.1 1.1 1 0 0 1 1 1 1 Sulfatase DUF1501 PF07394.12 ACT04498.1 - 0.091 11.8 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Phosphodiest PF01663.22 ACT04498.1 - 0.15 11.6 0.3 1.4 8.4 0.1 2.1 1 1 1 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase SLH PF00395.20 ACT04499.1 - 6.1e-26 90.2 1.7 2.2e-09 37.2 0.3 3.7 3 0 0 3 3 3 3 S-layer homology domain DUF4829 PF16111.5 ACT04499.1 - 0.015 16.1 0.5 0.025 15.4 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4829) SLH PF00395.20 ACT04500.1 - 5.4e-30 103.1 0.6 1e-09 38.2 0.0 3.6 3 0 0 3 3 3 3 S-layer homology domain Aldo_ket_red PF00248.21 ACT04501.1 - 1.9e-72 244.0 0.0 2.1e-72 243.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Glyoxalase_4 PF13669.6 ACT04502.1 - 9.3e-15 54.8 0.0 1.1e-14 54.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 ACT04502.1 - 3.8e-13 49.8 0.6 4.4e-13 49.5 0.6 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 ACT04502.1 - 6.6e-07 29.6 0.2 1.7e-06 28.2 0.2 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 ACT04502.1 - 0.00098 19.9 0.0 0.0012 19.6 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 ACT04502.1 - 0.0027 17.6 0.0 0.0069 16.3 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain Osmo_CC PF08946.10 ACT04502.1 - 0.14 12.4 0.6 5.6 7.3 0.1 2.7 2 1 1 3 3 3 0 Osmosensory transporter coiled coil AhpC-TSA PF00578.21 ACT04503.1 - 8.3e-40 135.6 0.0 9.4e-40 135.4 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ACT04503.1 - 1.4e-22 80.0 0.0 1.6e-22 79.8 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 ACT04503.1 - 9.7e-05 22.5 0.0 0.00033 20.8 0.0 1.7 1 1 1 2 2 2 1 AhpC/TSA antioxidant enzyme Asparaginase PF00710.20 ACT04504.1 - 1.5e-33 116.0 0.0 2e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 ACT04504.1 - 0.0011 19.2 0.0 0.0023 18.1 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain FAA_hydrolase PF01557.18 ACT04505.1 - 8.7e-49 166.1 0.0 1.1e-48 165.8 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Amidase PF01425.21 ACT04506.1 - 2.8e-61 207.9 0.0 1.6e-53 182.3 0.3 2.0 2 0 0 2 2 2 2 Amidase G_glu_transpept PF01019.21 ACT04507.1 - 9.3e-159 529.5 0.1 1e-158 529.3 0.1 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase HTH_AsnC-type PF13404.6 ACT04508.1 - 8.1e-16 57.6 0.3 1.2e-15 57.0 0.3 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 ACT04508.1 - 7e-15 54.3 0.5 1.4e-14 53.3 0.5 1.5 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 ACT04508.1 - 1.5e-12 47.3 0.0 2.3e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_Mga PF08280.11 ACT04508.1 - 9.8e-06 25.5 0.0 1.7e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_11 PF08279.12 ACT04508.1 - 2.5e-05 24.1 0.1 4.5e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 ACT04508.1 - 7.4e-05 22.6 0.0 0.00018 21.3 0.0 1.6 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT04508.1 - 0.0014 18.5 0.1 0.0025 17.6 0.1 1.3 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 ACT04508.1 - 0.0023 17.9 0.0 0.0043 17.0 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain TrmB PF01978.19 ACT04508.1 - 0.0032 17.3 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB GntR PF00392.21 ACT04508.1 - 0.0034 17.0 0.0 0.081 12.6 0.1 2.1 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_IclR PF09339.10 ACT04508.1 - 0.0053 16.5 0.0 0.0097 15.7 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_20 PF12840.7 ACT04508.1 - 0.011 15.7 0.0 0.035 14.1 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_41 PF14502.6 ACT04508.1 - 0.015 14.9 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain E3_UFM1_ligase PF09743.9 ACT04508.1 - 0.028 14.0 0.1 0.056 13.1 0.1 1.5 1 1 1 2 2 2 0 E3 UFM1-protein ligase 1 HTH_5 PF01022.20 ACT04508.1 - 0.044 13.6 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_36 PF13730.6 ACT04508.1 - 0.046 13.7 0.0 0.068 13.1 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DUF977 PF06163.11 ACT04508.1 - 0.05 13.5 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) HTH_9 PF08221.11 ACT04508.1 - 0.056 13.5 0.0 0.14 12.3 0.0 1.6 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 ACT04508.1 - 0.086 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 TFIIE alpha subunit FeoC PF09012.10 ACT04508.1 - 0.17 11.9 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 FeoC like transcriptional regulator Chromate_transp PF02417.15 ACT04509.1 - 1.3e-36 126.1 15.4 1.7e-36 125.8 15.4 1.0 1 0 0 1 1 1 1 Chromate transporter DUF2207 PF09972.9 ACT04509.1 - 2 7.1 7.3 2.7 6.7 7.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Chromate_transp PF02417.15 ACT04510.1 - 4.7e-35 121.1 11.4 5.4e-35 120.8 11.4 1.0 1 0 0 1 1 1 1 Chromate transporter 7TMR-DISM_7TM PF07695.11 ACT04510.1 - 0.0041 17.1 5.0 0.0041 17.1 5.0 1.5 2 0 0 2 2 2 1 7TM diverse intracellular signalling CPP1-like PF11833.8 ACT04510.1 - 0.028 14.1 2.2 0.036 13.7 1.3 1.6 1 1 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF1129 PF06570.11 ACT04510.1 - 0.2 11.2 3.1 0.28 10.7 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) AGTRAP PF06396.11 ACT04510.1 - 0.24 11.2 2.5 0.46 10.3 2.5 1.5 1 0 0 1 1 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) MMPL PF03176.15 ACT04511.1 - 1.2e-102 343.3 19.1 6.4e-56 189.7 0.6 3.9 4 0 0 4 4 4 2 MMPL family ACR_tran PF00873.19 ACT04511.1 - 1.3e-08 33.1 31.2 9e-08 30.3 4.3 2.7 3 0 0 3 3 3 2 AcrB/AcrD/AcrF family SHE3 PF17078.5 ACT04511.1 - 8.1e-05 22.4 0.0 0.015 15.0 0.0 2.3 1 1 1 2 2 2 1 SWI5-dependent HO expression protein 3 Baculo_PEP_C PF04513.12 ACT04511.1 - 0.00036 20.6 6.9 0.74 9.9 0.1 3.8 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 ACT04511.1 - 0.0013 18.8 0.1 2.8 8.0 0.0 3.8 1 1 3 4 4 4 1 Protein of unknown function (DUF1664) GAS PF13851.6 ACT04511.1 - 0.0023 17.3 0.0 0.014 14.8 0.0 2.2 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 ACT04511.1 - 0.018 14.4 4.6 0.95 8.7 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF3584 PF12128.8 ACT04511.1 - 0.021 12.4 4.2 0.68 7.4 3.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) APG17 PF04108.12 ACT04511.1 - 0.024 13.7 0.0 4.9 6.2 0.0 3.3 2 1 0 3 3 3 0 Autophagy protein Apg17 Nup54 PF13874.6 ACT04511.1 - 0.026 14.6 1.0 17 5.5 0.0 3.1 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 ALIX_LYPXL_bnd PF13949.6 ACT04511.1 - 0.036 13.3 2.3 0.12 11.6 1.9 1.8 1 1 1 2 2 2 0 ALIX V-shaped domain binding to HIV APG6_N PF17675.1 ACT04511.1 - 0.051 14.1 0.5 9.2 6.8 0.7 2.9 2 1 0 3 3 3 0 Apg6 coiled-coil region IFT57 PF10498.9 ACT04511.1 - 0.058 12.4 0.2 4.7 6.1 0.0 2.9 1 1 2 3 3 3 0 Intra-flagellar transport protein 57 Fibritin_C PF07921.12 ACT04511.1 - 0.1 12.8 6.8 6.1 7.1 0.1 3.8 3 0 0 3 3 3 0 Fibritin C-terminal region EzrA PF06160.12 ACT04511.1 - 0.12 10.6 0.0 0.31 9.2 0.0 1.6 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA ATG16 PF08614.11 ACT04511.1 - 0.12 12.6 5.2 0.55 10.4 0.8 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TMPIT PF07851.13 ACT04511.1 - 0.14 11.4 3.3 24 4.1 2.7 3.4 3 0 0 3 3 3 0 TMPIT-like protein LOH1CR12 PF10158.9 ACT04511.1 - 0.14 12.2 0.0 1.2 9.2 0.1 2.3 2 0 0 2 2 2 0 Tumour suppressor protein Tropomyosin_1 PF12718.7 ACT04511.1 - 0.16 12.1 0.0 18 5.5 0.0 2.7 2 1 0 2 2 2 0 Tropomyosin like Snapin_Pallidin PF14712.6 ACT04511.1 - 0.24 11.9 5.0 30 5.1 0.0 4.3 2 1 3 5 5 4 0 Snapin/Pallidin DASH_Dad3 PF08656.10 ACT04511.1 - 0.28 11.3 0.8 1.9 8.6 0.0 2.9 4 1 0 4 4 2 0 DASH complex subunit Dad3 CENP-F_leu_zip PF10473.9 ACT04511.1 - 0.36 10.9 0.7 12 5.9 0.0 2.8 2 1 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 ACT04511.1 - 0.42 10.7 6.0 12 6.0 4.1 2.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein MscS_porin PF12795.7 ACT04511.1 - 0.44 10.0 17.0 0.86 9.1 3.4 3.2 1 1 2 3 3 2 0 Mechanosensitive ion channel porin domain Laminin_II PF06009.12 ACT04511.1 - 0.48 10.4 1.4 57 3.7 0.1 3.2 1 1 2 4 4 4 0 Laminin Domain II HAUS-augmin3 PF14932.6 ACT04511.1 - 5.3 6.5 7.1 41 3.6 5.4 2.2 1 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 DASH_Dad2 PF08654.10 ACT04511.1 - 8.1 6.9 10.7 4.5 7.7 0.2 4.3 4 0 0 4 4 4 0 DASH complex subunit Dad2 MarR PF01047.22 ACT04512.1 - 5.1e-11 42.3 0.1 9.4e-11 41.5 0.1 1.5 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT04512.1 - 8.3e-10 39.0 0.5 1.6e-09 38.1 0.2 1.6 2 0 0 2 2 2 1 Winged helix DNA-binding domain MarR_2 PF12802.7 ACT04512.1 - 1.2e-06 28.3 0.0 2.6e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 MarR family Penicillinase_R PF03965.16 ACT04512.1 - 0.0071 16.7 0.1 0.013 15.8 0.1 1.5 1 1 0 1 1 1 1 Penicillinase repressor HTH_42 PF06224.12 ACT04512.1 - 0.049 13.2 0.0 0.06 12.9 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain Pyr_redox_2 PF07992.14 ACT04513.1 - 1.4e-13 50.7 8.9 5.7e-10 38.9 1.4 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ACT04513.1 - 1.3e-10 40.9 4.4 1.1e-06 28.0 0.1 3.0 2 1 1 3 3 3 2 FAD binding domain Pyr_redox_3 PF13738.6 ACT04513.1 - 1e-09 38.1 0.7 0.00056 19.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT04513.1 - 2e-09 37.5 1.0 0.0011 18.7 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 ACT04513.1 - 2.4e-08 33.1 0.5 1.6e-06 27.1 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 ACT04513.1 - 5.8e-08 32.2 7.3 2.3e-06 27.0 0.2 2.9 2 1 1 3 3 3 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 ACT04513.1 - 1.5e-07 31.2 0.4 7.3e-07 28.9 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ACT04513.1 - 4.4e-05 22.9 0.0 7.1e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ACT04513.1 - 6.8e-05 23.0 0.0 0.00036 20.7 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ACT04513.1 - 0.00087 18.6 0.0 0.0016 17.7 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 ACT04513.1 - 0.0022 18.0 0.3 0.3 11.0 0.1 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 ACT04513.1 - 0.0095 15.0 0.4 0.043 12.9 0.1 1.8 1 1 1 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 ACT04513.1 - 0.04 14.5 0.0 0.086 13.4 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ACT04513.1 - 0.069 12.3 0.1 0.51 9.4 0.0 1.9 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.18 ACT04513.1 - 0.093 12.6 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SHOCT PF09851.9 ACT04514.1 - 0.00024 20.7 0.4 0.00024 20.7 0.4 2.1 2 0 0 2 2 2 1 Short C-terminal domain DUF1707 PF08044.11 ACT04514.1 - 0.00035 20.6 0.2 0.0021 18.1 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1707) Sigma70_r4 PF04545.16 ACT04514.1 - 0.072 12.6 0.1 1.5 8.4 0.0 2.4 2 0 0 2 2 2 0 Sigma-70, region 4 Bac_GDH PF05088.12 ACT04514.1 - 0.096 10.2 0.2 0.12 9.8 0.2 1.1 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase Dynein_attach_N PF15867.5 ACT04514.1 - 0.1 12.6 0.3 0.22 11.5 0.3 1.5 1 0 0 1 1 1 0 Dynein attachment factor N-terminus LysM PF01476.20 ACT04514.1 - 0.19 11.9 0.0 0.47 10.6 0.0 1.7 1 0 0 1 1 1 0 LysM domain DUF4859 PF16151.5 ACT04514.1 - 0.77 9.6 5.3 13 5.7 1.5 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4859) MCPsignal PF00015.21 ACT04515.1 - 7.4e-44 149.6 51.9 1.4e-43 148.7 23.0 4.7 2 1 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 ACT04515.1 - 2.4e-15 56.6 3.3 4.1e-13 49.5 0.1 4.4 3 1 0 3 3 3 1 HAMP domain dCache_1 PF02743.18 ACT04515.1 - 9e-07 28.9 0.9 9e-07 28.9 0.9 3.5 2 1 1 3 3 2 1 Cache domain UPF0242 PF06785.11 ACT04515.1 - 2.1e-05 24.7 14.0 0.0065 16.6 0.2 3.8 2 1 2 4 4 4 2 Uncharacterised protein family (UPF0242) N-terminus CheZ PF04344.13 ACT04515.1 - 0.00027 20.9 21.1 0.019 14.9 2.1 2.7 2 1 0 2 2 2 2 Chemotaxis phosphatase, CheZ Mce4_CUP1 PF11887.8 ACT04515.1 - 0.0036 16.8 7.4 0.33 10.4 1.2 3.3 2 1 1 3 3 3 1 Cholesterol uptake porter CUP1 of Mce4, putative CorA PF01544.18 ACT04515.1 - 0.015 14.6 8.9 0.17 11.2 0.9 2.6 1 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Occludin_ELL PF07303.13 ACT04515.1 - 0.023 15.4 8.2 14 6.4 0.1 5.3 4 2 2 6 6 6 0 Occludin homology domain DUF4064 PF13273.6 ACT04515.1 - 0.039 14.2 1.1 1.6 9.0 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) ING PF12998.7 ACT04515.1 - 0.19 12.3 10.7 4.6 7.9 0.0 4.6 3 2 2 5 5 5 0 Inhibitor of growth proteins N-terminal histone-binding DUF948 PF06103.11 ACT04515.1 - 0.27 11.5 30.9 8.4 6.7 7.8 6.7 2 1 4 6 6 6 0 Bacterial protein of unknown function (DUF948) DUF769 PF05590.11 ACT04515.1 - 0.53 9.7 4.2 0.16 11.4 0.7 2.0 2 0 0 2 2 2 0 Xylella fastidiosa protein of unknown function (DUF769) DUF1664 PF07889.12 ACT04515.1 - 0.76 9.8 30.5 0.45 10.6 1.6 4.5 3 2 2 5 5 5 0 Protein of unknown function (DUF1664) ERM PF00769.19 ACT04515.1 - 1.1 9.0 27.8 0.57 10.0 5.3 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Vps53_N PF04100.12 ACT04515.1 - 1.3 7.9 21.6 0.18 10.7 3.3 3.3 1 1 1 3 3 3 0 Vps53-like, N-terminal BLOC1_2 PF10046.9 ACT04515.1 - 2.5 8.4 28.0 2.3 8.6 0.2 5.8 3 2 3 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sec34 PF04136.15 ACT04515.1 - 3.6 7.5 20.5 7.1 6.5 1.1 4.4 3 2 0 4 4 4 0 Sec34-like family DUF2970 PF11174.8 ACT04515.1 - 7.4 6.5 7.6 0.99 9.3 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Syntaxin_2 PF14523.6 ACT04515.1 - 9.1 6.7 25.1 5 7.6 2.2 5.3 2 1 3 5 5 4 0 Syntaxin-like protein ABC_membrane PF00664.23 ACT04516.1 - 5.9e-36 124.5 10.3 8.9e-36 123.9 8.0 2.0 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT04516.1 - 8.9e-33 113.7 0.0 1.7e-32 112.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ACT04516.1 - 5.1e-08 32.6 0.4 8e-05 22.2 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACT04516.1 - 1.5e-06 28.7 0.0 3e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 ACT04516.1 - 0.0011 19.0 0.1 0.036 14.1 0.0 2.8 3 0 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ACT04516.1 - 0.0023 17.9 0.0 0.005 16.8 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ACT04516.1 - 0.0057 16.9 0.0 0.031 14.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain Dynamin_N PF00350.23 ACT04516.1 - 0.0076 16.3 0.0 0.67 10.0 0.0 3.0 3 0 0 3 3 3 1 Dynamin family Zeta_toxin PF06414.12 ACT04516.1 - 0.012 15.0 0.0 0.12 11.6 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_15 PF13175.6 ACT04516.1 - 0.017 14.9 0.9 0.058 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 ACT04516.1 - 0.02 14.7 0.1 0.049 13.4 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF87 PF01935.17 ACT04516.1 - 0.044 13.9 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_23 PF13476.6 ACT04516.1 - 0.055 14.0 0.7 0.14 12.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ACT04516.1 - 0.057 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_10 PF12846.7 ACT04516.1 - 0.063 12.2 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_30 PF13604.6 ACT04516.1 - 0.096 12.4 0.0 0.33 10.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain CSD PF00313.22 ACT04516.1 - 0.14 12.0 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 'Cold-shock' DNA-binding domain SbcCD_C PF13558.6 ACT04516.1 - 0.17 12.2 0.4 1.3 9.3 0.4 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 ACT04516.1 - 0.19 11.5 0.9 6.5 6.5 0.1 2.3 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC_membrane PF00664.23 ACT04517.1 - 7.2e-43 147.2 4.3 1.1e-42 146.5 4.3 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ACT04517.1 - 4.4e-31 108.2 0.1 2.3e-30 105.9 0.0 2.1 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ACT04517.1 - 0.0002 20.9 0.2 0.02 14.3 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ACT04517.1 - 0.00038 20.7 0.0 0.0058 16.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ACT04517.1 - 0.0012 18.1 0.1 0.013 14.7 0.0 2.1 2 0 0 2 2 2 1 NB-ARC domain MobB PF03205.14 ACT04517.1 - 0.0019 18.1 0.3 0.022 14.6 0.1 2.3 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.6 ACT04517.1 - 0.0026 17.8 0.3 0.42 10.7 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ACT04517.1 - 0.0042 17.5 0.1 0.13 12.6 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ACT04517.1 - 0.007 16.3 0.0 0.019 14.9 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase ATP-synt_ab PF00006.25 ACT04517.1 - 0.01 15.5 0.0 0.024 14.3 0.0 1.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_33 PF13671.6 ACT04517.1 - 0.01 16.0 0.3 0.23 11.6 0.1 2.8 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 ACT04517.1 - 0.01 15.4 1.2 0.05 13.2 0.3 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ACT04517.1 - 0.013 15.6 0.1 0.06 13.4 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF87 PF01935.17 ACT04517.1 - 0.016 15.3 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_29 PF13555.6 ACT04517.1 - 0.016 14.9 0.4 0.088 12.6 0.2 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain T2SSE PF00437.20 ACT04517.1 - 0.041 12.9 0.1 0.11 11.5 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.12 ACT04517.1 - 0.046 13.6 0.2 0.11 12.4 0.2 1.6 1 0 0 1 1 1 0 NACHT domain Pox_A32 PF04665.12 ACT04517.1 - 0.056 12.9 0.1 0.094 12.2 0.1 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_23 PF13476.6 ACT04517.1 - 0.06 13.9 0.1 0.06 13.9 0.1 2.0 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 ACT04517.1 - 0.074 12.6 0.8 0.13 11.7 0.0 1.8 2 0 0 2 2 1 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 ACT04517.1 - 0.087 12.6 0.1 0.79 9.4 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TrwB_AAD_bind PF10412.9 ACT04517.1 - 0.096 11.6 0.1 0.22 10.4 0.1 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain KAP_NTPase PF07693.14 ACT04517.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain TsaE PF02367.17 ACT04517.1 - 0.19 11.7 0.3 0.5 10.4 0.1 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TP_methylase PF00590.20 ACT04518.1 - 1.1e-53 182.3 1.6 1.4e-53 182.1 1.6 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Radical_SAM PF04055.21 ACT04518.1 - 0.03 14.7 0.0 0.052 13.9 0.0 1.4 1 0 0 1 1 1 0 Radical SAM superfamily Form_Nir_trans PF01226.17 ACT04519.1 - 1.7e-64 217.4 29.3 2e-64 217.2 29.3 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter LapA_dom PF06305.11 ACT04519.1 - 1.6 8.6 11.8 7.2 6.5 0.0 3.5 2 1 2 4 4 4 0 Lipopolysaccharide assembly protein A domain Rieske PF00355.26 ACT04520.1 - 5e-16 58.4 0.1 5.6e-16 58.3 0.1 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 ACT04520.1 - 1.7e-12 47.1 0.0 2.1e-12 46.9 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Pyr_redox_2 PF07992.14 ACT04521.1 - 5.9e-58 196.4 0.5 1e-57 195.6 0.5 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 ACT04521.1 - 1.3e-26 93.0 0.3 2.5e-26 92.1 0.3 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Fer2_BFD PF04324.15 ACT04521.1 - 1.5e-26 92.5 10.6 1.6e-13 50.8 0.3 2.7 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Rubredoxin_C PF18267.1 ACT04521.1 - 6.7e-21 74.0 0.5 3.8e-20 71.6 0.2 2.2 2 0 0 2 2 2 1 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox PF00070.27 ACT04521.1 - 1.4e-17 64.0 2.6 6.5e-16 58.7 0.1 3.1 4 0 0 4 4 2 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR_ferr PF03460.17 ACT04521.1 - 1.7e-13 50.2 0.0 4.1e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Pyr_redox_3 PF13738.6 ACT04521.1 - 9.3e-11 41.5 0.0 1.7e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ACT04521.1 - 0.0011 19.0 6.6 0.55 10.2 0.0 4.2 3 1 0 4 4 4 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 ACT04521.1 - 0.0012 18.2 0.5 0.022 14.0 0.1 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 ACT04521.1 - 0.0052 17.2 0.1 0.31 11.5 0.0 2.6 2 0 0 2 2 2 1 Putative NAD(P)-binding HI0933_like PF03486.14 ACT04521.1 - 0.0077 15.0 1.2 2.3 6.8 0.0 3.2 2 1 1 3 3 3 1 HI0933-like protein 3HCDH_N PF02737.18 ACT04521.1 - 0.01 15.7 0.3 0.024 14.5 0.3 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.24 ACT04521.1 - 0.013 15.1 2.0 14 5.1 0.0 3.3 3 0 0 3 3 3 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ACT04521.1 - 0.02 13.8 0.0 0.1 11.4 0.0 2.0 2 0 0 2 2 2 0 Tryptophan halogenase CheB_methylest PF01339.17 ACT04521.1 - 0.033 13.9 0.2 0.18 11.5 0.0 2.2 3 0 0 3 3 2 0 CheB methylesterase Shikimate_DH PF01488.20 ACT04521.1 - 0.05 13.7 0.6 4.7 7.3 0.0 3.0 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase GIDA PF01134.22 ACT04521.1 - 0.077 12.1 1.7 0.55 9.3 0.6 2.6 2 1 1 3 3 3 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ACT04521.1 - 0.2 10.7 4.1 2.3 7.2 0.1 2.5 2 0 0 2 2 2 0 FAD binding domain ANTAR PF03861.14 ACT04522.1 - 1.9e-18 66.0 1.1 3.3e-18 65.2 1.1 1.4 1 0 0 1 1 1 1 ANTAR domain DUF3330 PF11809.8 ACT04522.1 - 0.055 13.5 0.0 0.098 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3330) TIP39 PF14980.6 ACT04522.1 - 2.4 8.1 6.9 4.5 7.2 0.2 2.9 2 1 1 3 3 3 0 TIP39 peptide Glycos_transf_3 PF00591.21 ACT04523.1 - 4.6e-34 118.2 0.0 6e-34 117.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 ACT04523.1 - 4.7e-12 45.6 0.7 1.4e-11 44.1 0.1 2.1 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain MFS_1 PF07690.16 ACT04524.1 - 2e-43 148.7 46.2 3e-43 148.1 46.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT04524.1 - 7.8e-09 34.9 10.6 7.8e-09 34.9 10.6 3.5 1 1 2 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.14 ACT04524.1 - 0.00057 19.3 33.5 0.00081 18.8 33.5 1.2 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB YdjO PF14169.6 ACT04525.1 - 3.9e-30 103.4 1.1 4.5e-30 103.1 1.1 1.1 1 0 0 1 1 1 1 Cold-inducible protein YdjO phage_tail_N PF08400.10 ACT04526.1 - 0.16 11.9 0.0 0.2 11.7 0.0 1.1 1 0 0 1 1 1 0 Prophage tail fibre N-terminal Pirin PF02678.16 ACT04527.1 - 1.8e-29 101.9 0.0 2.9e-29 101.2 0.0 1.3 1 0 0 1 1 1 1 Pirin Pirin_C_2 PF17954.1 ACT04527.1 - 1e-16 60.9 0.0 1.8e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Quercetinase C-terminal cupin domain Cupin_2 PF07883.11 ACT04527.1 - 0.00053 19.7 0.1 0.033 13.9 0.2 2.6 2 0 0 2 2 2 1 Cupin domain 60KD_IMP PF02096.20 ACT04529.1 - 3.7e-49 166.8 12.7 4.8e-49 166.4 12.7 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein DUF2062 PF09835.9 ACT04529.1 - 0.023 14.6 6.0 0.024 14.5 4.6 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) LPAM_2 PF13627.6 ACT04529.1 - 0.47 10.4 2.6 1.3 8.9 2.6 1.8 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site EMC3_TMCO1 PF01956.16 ACT04529.1 - 3.6 7.3 16.2 0.051 13.3 4.8 2.7 1 1 2 3 3 3 0 Integral membrane protein EMC3/TMCO1-like TMEM132 PF16070.5 ACT04530.1 - 0.093 12.0 0.0 0.1 11.9 0.0 1.0 1 0 0 1 1 1 0 Transmembrane protein family 132 Cu-oxidase_3 PF07732.15 ACT04531.1 - 3.8e-40 136.6 2.1 4.8e-35 120.2 0.1 2.4 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 ACT04531.1 - 1.5e-30 105.7 6.8 1.1e-23 83.4 3.0 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ACT04531.1 - 1.4e-16 61.1 0.5 3.8e-07 30.3 0.0 3.7 2 1 1 3 3 3 3 Multicopper oxidase SH3_2 PF07653.17 ACT04531.1 - 0.074 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain LysR_substrate PF03466.20 ACT04532.1 - 2.3e-54 183.9 0.3 2.9e-54 183.6 0.3 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT04532.1 - 4e-20 71.5 0.1 1.2e-19 69.9 0.1 1.9 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family DHDPS PF00701.22 ACT04533.1 - 3e-66 223.1 0.0 3.4e-66 222.9 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Lipase_GDSL_2 PF13472.6 ACT04533.1 - 0.044 14.2 0.0 0.076 13.4 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family PEP_mutase PF13714.6 ACT04533.1 - 0.054 12.9 0.1 0.085 12.3 0.1 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase Glycos_transf_2 PF00535.26 ACT04534.1 - 1.9e-14 53.8 0.0 2.4e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 ACT04534.1 - 0.00016 21.3 0.0 0.00017 21.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Aldo_ket_red PF00248.21 ACT04535.1 - 1.2e-75 254.5 0.0 1.3e-75 254.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TetR_N PF00440.23 ACT04536.1 - 1e-11 44.4 0.1 2e-11 43.5 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_13 PF16925.5 ACT04536.1 - 0.00074 19.4 0.0 0.00097 19.1 0.0 1.3 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain Terminase_5 PF06056.12 ACT04536.1 - 0.083 12.8 0.0 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) Flavodoxin_2 PF02525.17 ACT04537.1 - 7.7e-44 149.8 0.1 8.6e-44 149.6 0.1 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ACT04537.1 - 4.8e-06 26.4 0.0 1.1e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 NADPH-dependent FMN reductase DSBA PF01323.20 ACT04538.1 - 6.5e-29 101.1 0.0 7.3e-29 100.9 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 ACT04538.1 - 3.2e-06 27.4 0.0 0.00014 22.1 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 ACT04538.1 - 0.00011 22.1 0.0 0.087 12.9 0.0 2.6 3 0 0 3 3 3 2 Thioredoxin domain Tautomerase PF01361.21 ACT04539.1 - 2e-15 56.4 0.1 3.9e-15 55.5 0.1 1.4 1 1 0 1 1 1 1 Tautomerase enzyme Tautomerase_2 PF14552.6 ACT04539.1 - 0.002 18.2 0.0 0.0024 17.9 0.0 1.2 1 0 0 1 1 1 1 Tautomerase enzyme LysR_substrate PF03466.20 ACT04540.1 - 2.9e-45 154.2 0.0 3.8e-45 153.8 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT04540.1 - 3.7e-21 74.8 0.3 7.6e-21 73.8 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 ACT04540.1 - 0.003 17.4 0.0 0.0066 16.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family PBP_like PF12727.7 ACT04540.1 - 0.023 13.8 0.0 0.032 13.3 0.0 1.4 1 0 0 1 1 1 0 PBP superfamily domain HTH_24 PF13412.6 ACT04540.1 - 0.088 12.4 0.0 0.29 10.7 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ACT04540.1 - 0.1 12.5 0.1 0.47 10.4 0.0 2.2 2 0 0 2 2 2 0 MarR family HTH_30 PF13556.6 ACT04540.1 - 0.14 12.0 0.1 0.35 10.7 0.1 1.7 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain PBP_like_2 PF12849.7 ACT04540.1 - 0.22 11.1 0.0 0.77 9.4 0.0 1.8 2 0 0 2 2 2 0 PBP superfamily domain Cons_hypoth698 PF03601.14 ACT04541.1 - 1.3e-73 247.6 16.6 1.5e-73 247.3 16.6 1.0 1 0 0 1 1 1 1 Conserved hypothetical protein 698 GTP_EFTU PF00009.27 ACT04542.1 - 2e-58 197.2 0.0 3.3e-58 196.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ACT04542.1 - 1.8e-20 72.7 0.0 3.5e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 ACT04542.1 - 1.6e-14 53.7 0.0 3.5e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 ACT04542.1 - 1.1e-07 31.9 0.0 2e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ACT04542.1 - 1.5e-05 25.3 0.4 2.8e-05 24.4 0.4 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ACT04542.1 - 8.9e-05 22.5 0.0 0.00018 21.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ACT04542.1 - 0.056 13.0 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B RF3_C PF16658.5 ACT04542.1 - 0.061 13.2 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain DUF2961 PF11175.8 ACT04543.1 - 2.9e-89 298.7 3.2 3.9e-89 298.3 3.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2961) 5_nucleotid_C PF02872.18 ACT04544.1 - 1.1e-22 81.0 0.1 1.9e-22 80.2 0.1 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain LysM PF01476.20 ACT04544.1 - 2.4e-21 75.5 0.8 4.6e-21 74.6 0.8 1.5 1 0 0 1 1 1 1 LysM domain Metallophos PF00149.28 ACT04544.1 - 7.4e-11 42.9 0.8 1.3e-10 42.1 0.8 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Peptidase_M24 PF00557.24 ACT04545.1 - 4.8e-53 180.0 0.5 5.4e-53 179.8 0.5 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 ATP-cone PF03477.16 ACT04545.1 - 0.066 13.8 0.2 0.38 11.3 0.1 2.0 2 0 0 2 2 2 0 ATP cone domain EspB PF05802.11 ACT04546.1 - 6.9 6.6 16.6 8.3 6.3 16.6 1.0 1 0 0 1 1 1 0 Enterobacterial EspB protein HATPase_c PF02518.26 ACT04548.1 - 2.7e-23 82.6 0.0 5.6e-23 81.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT04548.1 - 3.1e-15 56.0 0.3 2.4e-14 53.1 0.0 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 ACT04548.1 - 2.1e-12 47.3 0.0 3.7e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 ACT04548.1 - 1.7e-10 40.9 0.0 3.8e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ACT04548.1 - 3e-10 40.3 0.0 1.1e-09 38.5 0.0 2.0 2 0 0 2 2 1 1 PAS domain PAS_8 PF13188.7 ACT04548.1 - 7.8e-09 35.4 0.0 2.2e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 PAS domain HAMP PF00672.25 ACT04548.1 - 4.4e-08 33.4 0.1 9.3e-08 32.3 0.1 1.6 1 0 0 1 1 1 1 HAMP domain HATPase_c_2 PF13581.6 ACT04548.1 - 0.002 18.1 0.0 0.0052 16.7 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 ACT04548.1 - 0.0033 17.3 0.0 0.0095 15.8 0.0 1.8 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 ACT04548.1 - 0.014 15.2 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 ACT04548.1 - 0.048 14.0 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 PAS fold Virulence_RhuM PF13310.6 ACT04548.1 - 0.077 12.2 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 Virulence protein RhuM family PBP-Tp47_c PF14888.6 ACT04548.1 - 0.092 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain C HPTransfase PF10090.9 ACT04548.1 - 0.15 11.8 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Histidine phosphotransferase C-terminal domain ABC_tran PF00005.27 ACT04549.1 - 2.3e-33 115.6 0.1 4.1e-33 114.8 0.1 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04549.1 - 3.6e-08 33.6 5.0 6.9e-05 22.8 0.2 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT04549.1 - 7e-07 28.9 0.3 2.7e-06 27.0 0.3 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT04549.1 - 0.00021 20.9 0.1 0.0004 20.1 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT04549.1 - 0.00036 20.5 0.1 0.00086 19.3 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ACT04549.1 - 0.00054 20.4 1.2 0.0015 18.9 1.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT04549.1 - 0.00056 20.2 1.7 0.012 15.9 1.7 2.3 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.6 ACT04549.1 - 0.00081 19.6 0.2 0.016 15.4 0.2 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 ACT04549.1 - 0.004 16.8 0.1 0.63 9.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ACT04549.1 - 0.0055 16.4 1.7 1.6 8.4 0.1 2.4 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ACT04549.1 - 0.0091 16.1 0.1 0.031 14.3 0.0 2.0 2 1 1 3 3 3 1 50S ribosome-binding GTPase Mg_chelatase PF01078.21 ACT04549.1 - 0.012 15.0 0.6 0.75 9.1 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 ACT04549.1 - 0.025 14.7 0.5 0.13 12.4 0.5 2.1 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 ACT04549.1 - 0.032 13.4 0.0 0.039 13.1 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_23 PF13476.6 ACT04549.1 - 0.033 14.7 0.9 0.068 13.7 0.0 1.8 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ACT04549.1 - 0.04 13.6 0.3 0.13 12.0 0.1 1.8 1 1 0 2 2 2 0 AAA ATPase domain DUF421 PF04239.12 ACT04549.1 - 0.054 13.3 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF421) AAA_28 PF13521.6 ACT04549.1 - 0.08 13.2 2.4 1.4 9.2 0.2 2.7 2 1 1 3 3 3 0 AAA domain Dynamin_N PF00350.23 ACT04549.1 - 0.083 12.9 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Dynamin family FeoB_N PF02421.18 ACT04549.1 - 0.11 12.1 0.1 0.27 10.7 0.0 1.7 2 0 0 2 2 2 0 Ferrous iron transport protein B NACHT PF05729.12 ACT04549.1 - 0.13 12.2 1.2 0.42 10.5 0.1 2.2 2 1 0 2 2 2 0 NACHT domain ATPase PF06745.13 ACT04549.1 - 0.18 11.1 0.2 13 5.0 0.0 2.2 2 0 0 2 2 2 0 KaiC cobW PF02492.19 ACT04549.1 - 0.21 11.2 0.3 4.1 7.0 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 ACT04549.1 - 0.22 11.3 0.1 0.52 10.0 0.1 1.6 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 ACT04549.1 - 0.32 11.1 1.1 0.74 9.9 0.1 2.0 2 1 0 2 2 2 0 Helicase HerA, central domain FtsX PF02687.21 ACT04550.1 - 9.5e-15 54.9 17.4 1.1e-08 35.4 5.3 5.2 6 1 0 6 6 6 2 FtsX-like permease family OSTMP1 PF09777.9 ACT04550.1 - 0.24 10.8 0.4 9.4 5.5 0.1 2.8 3 0 0 3 3 3 0 Osteopetrosis-associated transmembrane protein 1 precursor HlyD_D23 PF16576.5 ACT04551.1 - 3e-09 36.4 1.8 4.3e-09 35.9 1.8 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 ACT04551.1 - 7.6e-06 26.6 0.2 0.00074 20.2 0.0 2.4 2 0 0 2 2 2 1 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 ACT04551.1 - 8.9e-06 25.4 1.3 8.9e-06 25.4 1.3 3.3 3 1 0 3 3 3 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 ACT04551.1 - 0.00014 21.6 0.0 0.036 13.9 0.0 2.6 2 0 0 2 2 2 2 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 ACT04551.1 - 0.0032 17.2 0.1 3.2 7.5 0.1 2.4 2 0 0 2 2 2 2 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Peptidase_M23 PF01551.22 ACT04551.1 - 0.0043 17.2 0.0 0.91 9.8 0.0 2.7 2 1 0 2 2 2 1 Peptidase family M23 ABC_tran PF00005.27 ACT04552.1 - 6.6e-31 107.7 0.0 8.6e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04552.1 - 4.5e-06 26.7 0.7 0.027 14.3 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ACT04552.1 - 0.0021 17.5 0.0 0.048 13.1 0.0 2.0 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT04552.1 - 0.0053 16.5 0.2 0.0097 15.6 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT04552.1 - 0.0059 17.0 0.2 0.0091 16.4 0.2 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT04552.1 - 0.0071 16.6 0.1 0.19 12.0 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ACT04552.1 - 0.0084 15.8 0.4 0.055 13.2 0.1 2.2 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ACT04552.1 - 0.014 15.3 0.1 0.025 14.5 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 ACT04552.1 - 0.015 15.2 0.4 0.051 13.5 0.1 1.9 2 0 0 2 2 2 0 NACHT domain AAA_15 PF13175.6 ACT04552.1 - 0.019 14.7 0.0 1.3 8.7 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 ACT04552.1 - 0.026 13.7 0.0 0.33 10.1 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.15 ACT04552.1 - 0.11 12.4 0.1 6.3 6.7 0.0 2.2 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.6 ACT04552.1 - 0.12 12.0 1.3 0.62 9.6 0.2 2.3 2 1 0 2 2 2 0 AAA domain Hexapep PF00132.24 ACT04553.1 - 8.3e-09 34.8 3.4 8.3e-09 34.8 3.4 2.8 4 0 0 4 4 4 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ACT04553.1 - 0.00034 20.3 1.2 0.00055 19.6 0.4 1.9 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase Acetyltransf_11 PF13720.6 ACT04553.1 - 0.16 12.5 0.1 0.3 11.6 0.1 1.4 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 BPL_LplA_LipB PF03099.19 ACT04554.1 - 4.2e-06 26.7 0.0 6.6e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DDA1 PF10172.9 ACT04555.1 - 0.14 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Det1 complexing ubiquitin ligase RelA_SpoT PF04607.17 ACT04556.1 - 6.9e-37 126.3 0.1 6.9e-37 126.3 0.1 1.9 3 0 0 3 3 3 1 Region found in RelA / SpoT proteins YabA PF06156.13 ACT04556.1 - 0.26 12.0 4.9 0.97 10.1 0.4 2.5 2 0 0 2 2 2 0 Initiation control protein YabA PhzC-PhzF PF02567.16 ACT04557.1 - 2.5e-53 181.4 0.0 2.8e-53 181.2 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein ThrE_2 PF12821.7 ACT04558.1 - 4.1e-39 133.7 10.2 4.6e-39 133.5 10.2 1.0 1 0 0 1 1 1 1 Threonine/Serine exporter, ThrE ThrE PF06738.12 ACT04558.1 - 3.7e-11 42.9 9.6 4.8e-11 42.5 9.6 1.0 1 0 0 1 1 1 1 Putative threonine/serine exporter IncD PF17628.2 ACT04558.1 - 5.3 6.8 6.1 16 5.3 0.2 2.2 1 1 1 2 2 2 0 Inclusion membrane protein D ThrE PF06738.12 ACT04559.1 - 8.2e-75 251.3 7.9 9.2e-75 251.1 7.9 1.0 1 0 0 1 1 1 1 Putative threonine/serine exporter ThrE_2 PF12821.7 ACT04559.1 - 4.4e-14 52.7 11.3 7.2e-14 52.0 11.3 1.3 1 0 0 1 1 1 1 Threonine/Serine exporter, ThrE Mersacidin PF16934.5 ACT04559.1 - 6.2 6.7 6.5 1.3 8.8 0.2 2.8 3 0 0 3 3 3 0 Two-component Enterococcus faecalis cytolysin (EFC) MatE PF01554.18 ACT04560.1 - 5.8e-51 172.3 39.1 8.6e-27 93.8 9.3 2.7 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ACT04560.1 - 1.1e-09 38.4 10.5 1.1e-09 38.4 10.5 4.6 3 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Flp1_like PF16982.5 ACT04560.1 - 0.024 14.0 0.0 0.076 12.4 0.0 1.9 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain ROK PF00480.20 ACT04561.1 - 1.3e-32 113.4 0.0 1.6e-32 113.2 0.0 1.1 1 0 0 1 1 1 1 ROK family FeoC PF09012.10 ACT04561.1 - 0.0049 16.9 0.0 0.0098 15.9 0.0 1.4 1 0 0 1 1 1 1 FeoC like transcriptional regulator DUF4417 PF14386.6 ACT04561.1 - 0.22 11.1 0.0 0.43 10.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) Response_reg PF00072.24 ACT04562.1 - 1e-25 90.1 0.0 2.2e-25 89.0 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT04562.1 - 4.5e-22 78.1 0.0 1.2e-21 76.8 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04562.1 - 4.1e-20 71.4 0.1 2.6e-10 40.1 0.0 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF1514 PF07438.11 ACT04562.1 - 0.038 13.9 1.1 0.98 9.3 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1514) His_kinase PF06580.13 ACT04563.1 - 1.9e-22 79.3 0.4 6.5e-22 77.7 0.4 2.0 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT04563.1 - 3.3e-20 72.9 1.3 3.3e-20 72.9 1.3 1.7 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACT04563.1 - 7e-12 45.8 0.0 1.5e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT04563.1 - 2.7e-06 27.2 0.0 6.7e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT04563.1 - 2.5e-05 24.6 0.0 5.1e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 HAMP domain Sid-5 PF17204.3 ACT04563.1 - 0.039 14.1 5.0 6.1 7.1 0.1 3.3 3 0 0 3 3 3 0 Sid-5 family BPD_transp_1 PF00528.22 ACT04564.1 - 1.2e-20 74.0 19.8 1.2e-20 74.0 19.8 2.4 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04565.1 - 1e-11 44.9 13.5 1e-11 44.9 13.5 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Caveolin PF01146.17 ACT04565.1 - 7.7 6.5 10.6 0.3 11.0 3.1 2.4 2 0 0 2 2 2 0 Caveolin SBP_bac_1 PF01547.25 ACT04566.1 - 8.5e-42 144.2 12.5 1.4e-41 143.5 12.5 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT04566.1 - 4.2e-37 128.5 11.9 4.2e-37 128.5 11.9 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein Polysacc_deac_1 PF01522.21 ACT04567.1 - 1.4e-27 96.0 0.1 4.7e-27 94.3 0.1 1.9 2 1 0 2 2 2 1 Polysaccharide deacetylase Cu_amine_oxidN1 PF07833.11 ACT04567.1 - 8.8e-07 29.3 0.0 0.0028 18.1 0.0 2.5 2 0 0 2 2 2 2 Copper amine oxidase N-terminal domain DUF2334 PF10096.9 ACT04567.1 - 0.0015 18.2 0.3 0.0028 17.3 0.3 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Myb_Cef PF11831.8 ACT04567.1 - 0.076 12.6 1.4 0.098 12.2 0.2 1.7 2 0 0 2 2 2 0 pre-mRNA splicing factor component NAD_binding_10 PF13460.6 ACT04568.1 - 1.3e-41 142.5 0.0 1.5e-41 142.3 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT04568.1 - 3e-14 53.2 0.0 3.5e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 ACT04568.1 - 7.5e-05 22.3 0.1 0.00085 18.8 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 ACT04568.1 - 0.00013 22.3 0.1 0.00024 21.4 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 ACT04568.1 - 0.00065 19.8 0.1 0.0012 18.9 0.1 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus TrkA_N PF02254.18 ACT04568.1 - 0.0023 18.2 0.1 0.0039 17.4 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain PNP_UDP_1 PF01048.20 ACT04568.1 - 0.0094 15.2 0.0 0.016 14.5 0.0 1.5 1 1 0 1 1 1 1 Phosphorylase superfamily NAD_binding_2 PF03446.15 ACT04568.1 - 0.037 14.2 0.0 0.048 13.8 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 ACT04568.1 - 0.045 13.0 0.3 0.066 12.5 0.3 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain RmlD_sub_bind PF04321.17 ACT04568.1 - 0.06 12.4 0.2 0.12 11.4 0.2 1.5 1 1 0 1 1 1 0 RmlD substrate binding domain Semialdhyde_dh PF01118.24 ACT04568.1 - 0.073 13.5 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ACT04568.1 - 0.15 12.0 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 ACT04568.1 - 0.2 11.7 0.1 0.35 11.0 0.1 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain GSHPx PF00255.19 ACT04569.1 - 3.4e-34 116.7 0.4 4.4e-34 116.3 0.4 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 ACT04569.1 - 0.00041 20.2 0.1 0.00096 19.1 0.1 1.7 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ACT04569.1 - 0.01 15.6 0.0 0.029 14.1 0.0 1.7 1 1 0 1 1 1 1 Redoxin AHJR-like PF18743.1 ACT04569.1 - 0.15 11.7 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 REase_AHJR-like MarR PF01047.22 ACT04570.1 - 3.4e-14 52.5 0.2 5.2e-14 51.9 0.2 1.3 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT04570.1 - 3e-07 30.2 0.0 4.5e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 ACT04570.1 - 5.4e-06 26.8 0.2 8e-06 26.3 0.2 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_34 PF13601.6 ACT04570.1 - 0.00027 21.0 0.1 0.00047 20.3 0.1 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain PadR PF03551.14 ACT04570.1 - 0.0043 17.0 0.1 0.0075 16.2 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HxlR PF01638.17 ACT04570.1 - 0.0091 15.8 0.3 0.023 14.5 0.2 1.7 1 1 1 2 2 2 1 HxlR-like helix-turn-helix FeoC PF09012.10 ACT04570.1 - 0.014 15.4 0.6 0.028 14.5 0.0 1.8 2 0 0 2 2 2 0 FeoC like transcriptional regulator HTH_24 PF13412.6 ACT04570.1 - 0.03 13.9 0.0 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_micro PF17007.5 ACT04570.1 - 0.073 11.9 0.0 0.087 11.6 0.0 1.1 1 0 0 1 1 1 0 HTH-like TrmB PF01978.19 ACT04570.1 - 0.1 12.5 0.2 0.19 11.7 0.2 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB GntR PF00392.21 ACT04571.1 - 3.4e-11 42.6 0.0 2.3e-10 40.0 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Fe_dep_repress PF01325.19 ACT04571.1 - 0.00019 21.6 0.0 0.11 12.7 0.0 2.3 2 0 0 2 2 2 2 Iron dependent repressor, N-terminal DNA binding domain AbiEi_4 PF13338.6 ACT04571.1 - 0.025 14.7 0.0 0.13 12.4 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin CarD_CdnL_TRCF PF02559.16 ACT04571.1 - 0.036 14.8 0.0 0.087 13.5 0.0 1.6 1 1 1 2 2 2 0 CarD-like/TRCF domain ABC_tran PF00005.27 ACT04572.1 - 2.6e-17 63.6 0.0 4e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04572.1 - 9.5e-09 35.5 0.5 3.2e-05 23.9 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ACT04572.1 - 3.1e-05 24.6 0.0 5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_27 PF13514.6 ACT04572.1 - 0.014 15.0 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 ACT04572.1 - 0.019 14.4 0.1 0.52 9.7 0.1 2.2 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ACT04572.1 - 0.02 14.6 0.1 0.043 13.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 ACT04572.1 - 0.02 15.2 0.1 0.35 11.1 0.1 2.4 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ACT04572.1 - 0.045 13.5 0.2 0.18 11.5 0.0 1.7 1 1 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 ACT04572.1 - 0.058 13.9 0.1 0.17 12.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ACT04572.1 - 0.072 12.4 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 ACT04572.1 - 0.085 12.8 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 ACT04572.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ACT04572.1 - 0.18 12.2 0.0 0.39 11.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Luciferase_cat PF10285.9 ACT04573.1 - 0.14 11.5 0.1 0.2 11.0 0.1 1.1 1 0 0 1 1 1 0 Luciferase catalytic domain ELFV_dehydrog_N PF02812.18 ACT04574.1 - 1.2e-27 96.3 0.0 2.8e-27 95.2 0.0 1.6 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 ACT04574.1 - 2.1e-20 73.5 0.7 3.6e-11 43.3 0.0 2.1 1 1 1 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 ACT04574.1 - 0.002 17.5 0.0 0.0035 16.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.21 ACT04574.1 - 0.015 14.7 0.3 0.025 14.0 0.3 1.3 1 0 0 1 1 1 0 ThiF family NAD_binding_2 PF03446.15 ACT04574.1 - 0.02 15.0 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 ACT04574.1 - 0.021 14.9 0.4 0.036 14.1 0.4 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ACT04574.1 - 0.023 14.3 0.1 0.042 13.4 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain adh_short PF00106.25 ACT04574.1 - 0.029 13.8 0.3 0.26 10.7 0.1 2.2 1 1 1 2 2 2 0 short chain dehydrogenase TrkA_N PF02254.18 ACT04574.1 - 0.075 13.3 0.2 0.17 12.1 0.2 1.6 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 ACT04574.1 - 0.22 11.4 0.4 0.48 10.3 0.4 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Peptidase_M20 PF01546.28 ACT04575.1 - 1.2e-12 47.9 0.0 4.2e-12 46.2 0.0 1.8 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ACT04575.1 - 1.5e-12 47.4 0.2 2.9e-12 46.5 0.2 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.14 ACT04575.1 - 0.00017 20.7 0.0 0.052 12.6 0.0 2.5 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase Flavin_Reduct PF01613.18 ACT04576.1 - 4.7e-21 75.4 0.1 6.2e-21 75.1 0.1 1.1 1 0 0 1 1 1 1 Flavin reductase like domain DLH PF01738.18 ACT04577.1 - 1.6e-07 31.1 0.0 2.7e-07 30.4 0.0 1.4 2 0 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 ACT04577.1 - 1.2e-06 27.9 0.0 0.0023 17.2 0.0 2.5 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 ACT04577.1 - 3.5e-05 23.7 0.0 0.00088 19.1 0.0 2.0 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 ACT04577.1 - 0.0012 18.4 0.0 0.064 12.7 0.0 2.1 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 ACT04577.1 - 0.0036 17.2 0.0 0.0067 16.3 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 ACT04577.1 - 0.019 15.1 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_1 PF00561.20 ACT04577.1 - 0.03 14.0 0.1 0.088 12.4 0.1 1.9 1 1 1 2 2 2 0 alpha/beta hydrolase fold DUF915 PF06028.11 ACT04577.1 - 0.032 13.5 0.0 0.69 9.2 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Glyoxalase PF00903.25 ACT04578.1 - 7.6e-32 110.2 0.6 8.6e-31 106.8 0.6 2.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MarR PF01047.22 ACT04579.1 - 3.5e-19 68.5 0.0 5.8e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 ACT04579.1 - 1.4e-11 44.1 0.0 2.4e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 ACT04579.1 - 1.6e-07 30.8 0.0 2.6e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_27 PF13463.6 ACT04579.1 - 3.2e-07 30.7 0.0 5.6e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_34 PF13601.6 ACT04579.1 - 1.5e-06 28.3 0.0 2.2e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.19 ACT04579.1 - 5.9e-06 26.1 0.2 2e-05 24.4 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB PadR PF03551.14 ACT04579.1 - 0.0031 17.5 0.0 0.0059 16.6 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family Penicillinase_R PF03965.16 ACT04579.1 - 0.023 15.0 0.0 0.049 14.0 0.0 1.6 1 0 0 1 1 1 0 Penicillinase repressor HTH_20 PF12840.7 ACT04579.1 - 0.024 14.7 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain B-block_TFIIIC PF04182.12 ACT04579.1 - 0.04 14.1 0.0 0.056 13.6 0.0 1.4 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC PG_binding_1 PF01471.18 ACT04580.1 - 3.3e-12 46.4 0.0 4.9e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Glyco_hydro_115 PF15979.5 ACT04581.1 - 3.7e-147 490.2 3.7 5.1e-147 489.7 3.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 ACT04581.1 - 1.6e-61 207.1 0.0 3.5e-61 206.0 0.0 1.6 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain Glyco_hydro_67N PF03648.14 ACT04581.1 - 0.00018 21.8 0.1 0.00033 20.9 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus FR47 PF08445.10 ACT04582.1 - 2.2e-07 30.7 0.0 3.9e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ACT04582.1 - 0.00082 20.1 0.0 0.0013 19.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 ACT04582.1 - 0.0022 17.6 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_1 PF00583.25 ACT04582.1 - 0.0034 17.6 0.0 0.0057 16.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ACT04582.1 - 0.016 15.2 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ACT04582.1 - 0.018 15.4 0.0 0.039 14.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Phage_Coat_B PF05356.11 ACT04583.1 - 0.016 15.1 1.4 0.025 14.5 0.4 1.7 2 0 0 2 2 2 0 Phage Coat protein B Rhamno_transf PF11316.8 ACT04584.1 - 8e-10 38.5 0.0 1.2e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Putative rhamnosyl transferase NigD_N PF12667.7 ACT04584.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 NigD-like N-terminal OB domain SASP PF00269.20 ACT04585.1 - 1.1e-15 57.4 6.1 2.9e-15 56.0 6.1 1.8 1 1 0 1 1 1 1 Small, acid-soluble spore proteins, alpha/beta type TcdB_toxin_midC PF12255.8 ACT04585.1 - 0.033 14.3 0.0 0.041 14.0 0.0 1.2 1 0 0 1 1 1 0 Insecticide toxin TcdB middle/C-terminal region DUF1284 PF06935.11 ACT04586.1 - 1.1e-25 90.0 0.0 1.4e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1284) DNA_binding_1 PF01035.20 ACT04587.1 - 5.8e-24 84.0 0.1 6.9e-24 83.8 0.1 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Tic110 PF16940.5 ACT04587.1 - 0.028 12.9 0.0 0.034 12.6 0.0 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter MFS_1 PF07690.16 ACT04588.1 - 5.3e-60 203.2 36.1 2e-58 198.0 35.9 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT04588.1 - 9.7e-13 47.8 8.5 9.7e-13 47.8 8.5 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 ACT04588.1 - 1.5e-06 27.0 17.4 4.2e-06 25.5 14.3 2.5 1 1 2 3 3 3 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 ACT04588.1 - 3.5e-06 25.9 5.2 3.5e-06 25.9 5.2 2.9 2 1 0 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.7 ACT04588.1 - 5.8e-05 22.1 16.1 0.00056 18.9 5.7 2.3 2 0 0 2 2 2 2 MFS_1 like family MFS_3 PF05977.13 ACT04588.1 - 0.001 17.5 3.4 0.001 17.5 3.4 1.7 2 0 0 2 2 2 1 Transmembrane secretion effector Aldedh PF00171.22 ACT04589.1 - 9.3e-96 321.1 0.0 1.1e-95 320.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family YhhN PF07947.14 ACT04590.1 - 1.3e-40 138.9 19.8 1.3e-40 138.9 19.8 1.3 2 0 0 2 2 2 1 YhhN family Radical_SAM PF04055.21 ACT04591.1 - 4.6e-17 62.9 0.0 8.9e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 ACT04591.1 - 1.8e-06 28.1 0.0 6.8e-06 26.2 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 ACT04591.1 - 0.0023 18.2 0.1 0.017 15.4 0.0 2.1 2 0 0 2 2 2 1 4Fe-4S single cluster domain Biotin_carb_N PF00289.22 ACT04592.1 - 0.053 14.1 0.0 0.15 12.7 0.0 1.6 2 0 0 2 2 2 0 Biotin carboxylase, N-terminal domain TrkA_N PF02254.18 ACT04592.1 - 0.053 13.8 0.0 0.7 10.2 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain DUF2892 PF11127.8 ACT04593.1 - 0.012 15.6 0.2 0.013 15.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2892) DUF2681 PF10883.8 ACT04593.1 - 0.023 15.1 0.1 0.023 15.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF2556 PF10831.8 ACT04593.1 - 0.045 13.7 0.3 0.045 13.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2556) KdpA PF03814.15 ACT04594.1 - 3.2e-246 817.8 32.1 3.8e-246 817.6 32.1 1.0 1 0 0 1 1 1 1 Potassium-transporting ATPase A subunit DUF2754 PF10953.8 ACT04594.1 - 0.45 10.8 2.5 7.4 6.9 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2754) Hydrolase PF00702.26 ACT04595.1 - 5.2e-35 121.6 0.4 9.2e-35 120.8 0.4 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ACT04595.1 - 8e-35 120.0 4.6 8e-35 120.0 4.6 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ACT04595.1 - 7.2e-07 29.2 0.4 0.00039 20.2 0.4 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ACT04595.1 - 0.0018 18.7 0.0 0.0096 16.3 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase KdpC PF02669.15 ACT04596.1 - 7.1e-71 237.8 0.0 8.5e-71 237.5 0.0 1.1 1 0 0 1 1 1 1 K+-transporting ATPase, c chain KdpD PF02702.17 ACT04597.1 - 1.2e-161 534.6 2.5 7.6e-92 306.5 0.4 2.3 2 0 0 2 2 2 2 Osmosensitive K+ channel His kinase sensor domain Usp PF00582.26 ACT04597.1 - 1.9e-08 34.9 0.9 0.0083 16.6 0.2 3.9 2 2 0 2 2 2 2 Universal stress protein family AAA_30 PF13604.6 ACT04597.1 - 0.00039 20.2 0.0 0.92 9.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 ACT04597.1 - 0.00056 20.0 1.6 0.74 9.8 0.1 3.0 2 1 0 3 3 3 2 Type III restriction enzyme, res subunit PAS_8 PF13188.7 ACT04597.1 - 0.14 12.2 0.0 0.73 9.9 0.0 2.3 2 0 0 2 2 2 0 PAS domain Titin_Ig-rpts PF06582.12 ACT04597.1 - 4.7 7.2 6.1 4.6 7.3 0.1 3.2 3 0 0 3 3 3 0 Titin repeat Epimerase PF01370.21 ACT04598.1 - 7.8e-06 25.5 0.0 1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ACT04598.1 - 0.00063 19.7 0.0 0.0011 18.9 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 ACT04598.1 - 0.0024 18.1 0.0 0.0036 17.6 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 ACT04598.1 - 0.0068 16.8 0.0 0.014 15.8 0.0 1.5 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 ACT04598.1 - 0.0079 16.3 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.12 ACT04598.1 - 0.0081 15.4 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NmrA PF05368.13 ACT04598.1 - 0.22 11.1 0.0 0.5 9.9 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family Pyr_redox_2 PF07992.14 ACT04599.1 - 1.1e-26 93.7 0.0 1.4e-26 93.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACT04599.1 - 2.2e-25 89.5 0.4 1.3e-23 83.8 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT04599.1 - 7.3e-09 36.1 2.7 7.1e-06 26.5 0.0 3.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ACT04599.1 - 1.8e-08 33.5 0.1 0.0011 17.8 0.0 3.1 3 1 1 4 4 4 2 HI0933-like protein K_oxygenase PF13434.6 ACT04599.1 - 4.4e-06 26.1 0.1 0.00024 20.4 0.0 2.4 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 ACT04599.1 - 0.00049 19.6 0.0 0.0061 16.0 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FMO-like PF00743.19 ACT04599.1 - 0.00053 18.5 0.0 0.00093 17.7 0.0 1.4 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like FAD_binding_2 PF00890.24 ACT04599.1 - 0.0017 17.5 0.0 2.2 7.2 0.0 3.7 2 1 1 3 3 3 1 FAD binding domain Thi4 PF01946.17 ACT04599.1 - 0.0031 16.8 0.0 0.12 11.7 0.0 2.4 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 ACT04599.1 - 0.0056 15.8 0.1 1.4 7.9 0.0 2.7 3 0 0 3 3 3 2 Glucose inhibited division protein A NAD_binding_8 PF13450.6 ACT04599.1 - 0.029 14.6 0.0 0.083 13.1 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ACT04599.1 - 0.18 11.3 1.3 16 4.9 0.1 2.9 1 1 2 3 3 3 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ACT04599.1 - 0.19 11.7 0.2 5.6 6.9 0.0 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding Peripla_BP_2 PF01497.18 ACT04600.1 - 2e-29 102.8 1.6 2e-29 102.8 1.6 1.4 2 0 0 2 2 2 1 Periplasmic binding protein FecCD PF01032.18 ACT04601.1 - 3.8e-85 285.6 36.3 4.5e-85 285.4 36.3 1.0 1 0 0 1 1 1 1 FecCD transport family ABC-3 PF00950.17 ACT04601.1 - 0.072 12.6 25.9 0.21 11.1 25.9 1.9 1 1 0 1 1 1 0 ABC 3 transport family DUF2631 PF10939.8 ACT04601.1 - 2.3 8.1 5.3 0.49 10.3 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2631) FecCD PF01032.18 ACT04602.1 - 2.5e-82 276.4 32.8 3e-82 276.1 32.8 1.0 1 0 0 1 1 1 1 FecCD transport family FAD_binding_2 PF00890.24 ACT04603.1 - 3.3e-109 365.7 1.0 3.7e-109 365.6 1.0 1.0 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ACT04603.1 - 1.8e-06 28.1 0.4 1.1e-05 25.5 0.4 2.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ACT04603.1 - 5.6e-05 22.0 0.4 5.6e-05 22.0 0.4 2.1 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 ACT04603.1 - 0.00013 21.5 0.2 0.00022 20.7 0.2 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ACT04603.1 - 0.00037 19.7 0.3 0.00052 19.2 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 ACT04603.1 - 0.00043 19.6 0.7 0.0016 17.7 0.4 2.1 3 0 0 3 3 3 1 Thi4 family GIDA PF01134.22 ACT04603.1 - 0.0005 19.3 1.1 0.0005 19.3 1.1 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 ACT04603.1 - 0.00084 18.7 0.3 0.0037 16.5 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ACT04603.1 - 0.0016 17.7 0.0 0.0032 16.7 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ACT04603.1 - 0.002 17.8 5.7 0.0046 16.6 5.6 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 ACT04603.1 - 0.13 11.6 0.9 0.24 10.7 0.2 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 ACT04603.1 - 0.28 10.4 0.1 0.42 9.8 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase WYL PF13280.6 ACT04604.1 - 8.8e-22 78.0 0.1 1.6e-21 77.2 0.1 1.3 1 0 0 1 1 1 1 WYL domain HTH_11 PF08279.12 ACT04604.1 - 7.8e-14 51.4 0.0 1.5e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 HTH domain HTH_DeoR PF08220.12 ACT04604.1 - 6.4e-06 25.8 0.1 1.2e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_AsnC-type PF13404.6 ACT04604.1 - 0.00029 20.6 0.2 0.00071 19.4 0.2 1.7 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_23 PF13384.6 ACT04604.1 - 0.00051 19.7 0.2 0.0023 17.7 0.2 2.1 2 0 0 2 2 2 1 Homeodomain-like domain Rrf2 PF02082.20 ACT04604.1 - 0.0011 19.3 0.0 0.0022 18.3 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator HTH_22 PF13309.6 ACT04604.1 - 0.0014 18.7 0.0 0.003 17.6 0.0 1.6 1 0 0 1 1 1 1 HTH domain HTH_28 PF13518.6 ACT04604.1 - 0.0014 18.7 0.1 0.005 16.9 0.1 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 ACT04604.1 - 0.0049 16.7 0.1 0.011 15.6 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_29 PF13551.6 ACT04604.1 - 0.0074 16.3 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_20 PF12840.7 ACT04604.1 - 0.0079 16.2 0.9 0.018 15.1 0.1 1.9 2 1 0 2 2 2 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 ACT04604.1 - 0.022 14.4 4.7 0.44 10.3 0.1 3.5 4 0 0 4 4 4 0 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACT04604.1 - 0.044 13.7 0.2 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 ECF sigma factor HTH_5 PF01022.20 ACT04604.1 - 0.05 13.5 0.7 0.1 12.5 0.1 1.8 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 ACT04604.1 - 0.051 13.1 0.1 0.09 12.4 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_38 PF13936.6 ACT04604.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MFS_1 PF07690.16 ACT04605.1 - 4.7e-07 29.1 52.0 7.4e-05 21.8 13.2 3.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sulfatase PF00884.23 ACT04606.1 - 9.9e-39 133.5 1.2 1.3e-38 133.2 1.2 1.1 1 0 0 1 1 1 1 Sulfatase TetR_N PF00440.23 ACT04607.1 - 8.7e-15 54.3 0.0 1.6e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_24 PF17932.1 ACT04607.1 - 6.6e-05 23.1 1.4 0.00011 22.4 0.6 1.8 1 1 1 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_C_7 PF14246.6 ACT04607.1 - 0.018 15.1 0.4 0.04 13.9 0.1 1.8 2 1 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain HAD_2 PF13419.6 ACT04607.1 - 0.11 12.5 0.0 0.27 11.3 0.0 1.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Bactofilin PF04519.13 ACT04608.1 - 2.5e-05 24.5 10.1 0.00087 19.5 5.3 2.6 2 1 1 3 3 3 2 Polymer-forming cytoskeletal DUF3617 PF12276.8 ACT04608.1 - 0.16 12.3 0.2 0.37 11.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3617) Bactofilin PF04519.13 ACT04609.1 - 8e-09 35.7 8.9 1.4e-08 34.9 4.1 2.8 2 1 1 3 3 3 2 Polymer-forming cytoskeletal DUF2807 PF10988.8 ACT04609.1 - 0.0053 16.6 5.6 0.18 11.6 3.5 2.6 2 1 0 2 2 2 1 Putative auto-transporter adhesin, head GIN domain DUF4004 PF13171.6 ACT04610.1 - 1.1e-85 286.9 1.2 1.2e-85 286.7 1.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4004) DUF3261 PF11659.8 ACT04610.1 - 0.0097 15.8 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3261) HTH_26 PF13443.6 ACT04610.1 - 0.013 15.9 0.3 0.1 13.0 0.0 2.4 3 0 0 3 3 3 0 Cro/C1-type HTH DNA-binding domain Phage_CI_repr PF07022.13 ACT04610.1 - 0.029 14.5 0.0 0.42 10.7 0.0 2.2 2 0 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain HTH_28 PF13518.6 ACT04610.1 - 0.09 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MFS_1 PF07690.16 ACT04612.1 - 6.7e-47 160.1 62.5 1.2e-32 113.2 33.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ACT04612.1 - 0.0006 19.2 39.1 0.00077 18.9 39.1 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB BT1 PF03092.16 ACT04612.1 - 0.0018 16.6 3.0 0.0018 16.6 3.0 2.3 2 1 1 3 3 3 1 BT1 family MFS_2 PF13347.6 ACT04612.1 - 0.0023 16.5 14.3 0.0023 16.5 14.3 3.0 1 1 2 3 3 3 2 MFS/sugar transport protein Sugar_tr PF00083.24 ACT04612.1 - 0.51 9.1 41.9 1.1 8.0 21.0 3.2 2 2 0 2 2 2 0 Sugar (and other) transporter KleE PF17394.2 ACT04612.1 - 1 9.6 6.5 1 9.6 1.7 2.9 2 1 0 2 2 2 0 Uncharacterized KleE stable inheritance protein MerR_1 PF13411.6 ACT04613.1 - 3e-20 72.1 0.2 3e-20 72.1 0.2 2.0 2 1 0 2 2 2 1 MerR HTH family regulatory protein MerR PF00376.23 ACT04613.1 - 1.7e-16 59.7 0.2 3e-16 58.9 0.2 1.4 1 0 0 1 1 1 1 MerR family regulatory protein PLU-1 PF08429.11 ACT04613.1 - 0.0031 16.8 3.6 0.0042 16.3 3.6 1.3 1 0 0 1 1 1 1 PLU-1-like protein CK2S PF15011.6 ACT04613.1 - 0.022 14.6 4.5 0.031 14.2 4.5 1.2 1 0 0 1 1 1 0 Casein Kinase 2 substrate HTH_3 PF01381.22 ACT04613.1 - 0.023 14.7 0.2 0.22 11.6 0.0 2.4 2 1 1 3 3 3 0 Helix-turn-helix HTH_17 PF12728.7 ACT04613.1 - 0.027 14.6 0.1 0.11 12.7 0.0 2.0 2 1 0 2 2 2 0 Helix-turn-helix domain MerR-DNA-bind PF09278.11 ACT04613.1 - 0.043 14.3 8.9 0.76 10.4 8.9 2.3 1 1 0 1 1 1 0 MerR, DNA binding AAA_23 PF13476.6 ACT04613.1 - 0.12 12.8 6.2 0.14 12.6 6.2 1.1 1 0 0 1 1 1 0 AAA domain DUF16 PF01519.16 ACT04613.1 - 0.13 12.8 7.3 0.81 10.2 3.9 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 Atg14 PF10186.9 ACT04613.1 - 0.32 10.0 7.6 0.37 9.8 7.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 L31 PF09784.9 ACT04613.1 - 0.34 11.4 3.8 0.51 10.8 3.2 1.6 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L31 DUF1515 PF07439.11 ACT04613.1 - 1.2 9.2 3.7 2.5 8.2 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) FapA PF03961.13 ACT04613.1 - 1.2 7.6 8.3 1.4 7.4 8.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Snapin_Pallidin PF14712.6 ACT04613.1 - 1.2 9.6 10.8 2 8.9 9.3 2.0 1 1 1 2 2 2 0 Snapin/Pallidin DUF1664 PF07889.12 ACT04613.1 - 1.6 8.8 6.0 1.7 8.7 4.8 1.8 2 1 0 2 2 1 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 ACT04613.1 - 1.7 8.8 8.8 4 7.6 8.8 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 ACT04613.1 - 1.7 9.1 6.7 1.2 9.6 3.6 2.4 2 2 0 2 2 2 0 Flagella accessory protein C (FlaC) zf-C4H2 PF10146.9 ACT04613.1 - 1.8 8.8 7.7 2.8 8.2 7.7 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein Laminin_II PF06009.12 ACT04613.1 - 1.9 8.5 9.5 7.3 6.6 9.6 1.8 1 1 0 1 1 1 0 Laminin Domain II ADH_zinc_N PF00107.26 ACT04614.1 - 4.3e-22 78.5 0.2 7.2e-22 77.8 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ACT04614.1 - 1.2e-17 65.2 0.0 2.4e-17 64.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ACT04614.1 - 1e-08 35.0 0.0 3.4e-08 33.3 0.0 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain GntR PF00392.21 ACT04615.1 - 2.5e-20 71.9 1.0 6.8e-20 70.5 0.1 2.1 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family FCD PF07729.12 ACT04615.1 - 3.7e-11 43.5 0.1 5.5e-11 43.0 0.1 1.2 1 0 0 1 1 1 1 FCD domain HTH_24 PF13412.6 ACT04615.1 - 2e-06 27.2 1.1 6.3e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.6 ACT04615.1 - 0.00019 21.3 0.0 0.0005 20.0 0.0 1.7 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_11 PF08279.12 ACT04615.1 - 0.00021 21.2 0.0 0.00063 19.6 0.0 1.9 1 0 0 1 1 1 1 HTH domain HTH_IclR PF09339.10 ACT04615.1 - 0.0023 17.7 0.1 0.008 16.0 0.1 1.9 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 ACT04615.1 - 0.0056 16.5 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB PaaX PF07848.12 ACT04615.1 - 0.012 15.8 0.0 0.035 14.3 0.0 1.7 1 1 1 2 2 2 0 PaaX-like protein HTH_AsnC-type PF13404.6 ACT04615.1 - 0.014 15.2 0.9 0.028 14.2 0.1 2.0 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Fe_dep_repress PF01325.19 ACT04615.1 - 0.027 14.7 0.1 0.095 12.9 0.0 1.9 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain TFIIE_alpha PF02002.17 ACT04615.1 - 0.04 13.8 0.1 0.27 11.1 0.0 2.1 2 0 0 2 2 2 0 TFIIE alpha subunit Rrf2 PF02082.20 ACT04615.1 - 0.062 13.7 0.1 0.27 11.6 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator SF3A3 PF16837.5 ACT04615.1 - 0.067 13.7 0.1 0.11 13.0 0.1 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 HTH_54 PF18607.1 ACT04615.1 - 0.07 13.2 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 ParA helix turn helix domain HTH_36 PF13730.6 ACT04615.1 - 0.082 12.9 0.0 0.3 11.1 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_20 PF12840.7 ACT04615.1 - 0.091 12.8 0.0 1.2 9.3 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain Phosphonate-bd PF12974.7 ACT04616.1 - 1.8e-61 207.8 0.1 2.1e-61 207.6 0.1 1.0 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1 PF09084.11 ACT04616.1 - 6.6e-11 42.6 0.1 1.6e-10 41.3 0.1 1.6 1 1 0 1 1 1 1 NMT1/THI5 like SBP_bac_3 PF00497.20 ACT04616.1 - 2.7e-06 27.0 0.0 8.8e-06 25.3 0.0 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1_2 PF13379.6 ACT04616.1 - 6.6e-06 26.0 0.0 9.7e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 NMT1-like family NMT1_3 PF16868.5 ACT04616.1 - 0.00018 21.1 0.0 0.00051 19.6 0.0 1.7 1 1 0 1 1 1 1 NMT1-like family ABC2_membrane_3 PF12698.7 ACT04616.1 - 0.00045 19.4 0.0 0.00055 19.1 0.0 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein Lipoprotein_9 PF03180.14 ACT04616.1 - 0.061 12.4 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 NLPA lipoprotein OpuAC PF04069.12 ACT04616.1 - 0.068 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system LPAM_1 PF08139.12 ACT04616.1 - 0.62 10.7 3.8 1.9 9.2 3.8 1.9 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site BPD_transp_1 PF00528.22 ACT04617.1 - 7.1e-22 78.0 12.6 7.1e-22 78.0 12.6 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Tim17 PF02466.19 ACT04617.1 - 0.06 13.7 0.5 0.14 12.5 0.6 1.8 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family OAD_gamma PF04277.13 ACT04617.1 - 0.38 11.4 2.3 1.1 9.9 0.4 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain BPD_transp_1 PF00528.22 ACT04618.1 - 6.1e-15 55.4 19.5 6.1e-15 55.4 19.5 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 ACT04619.1 - 1.5e-35 122.6 0.0 2.5e-35 122.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04619.1 - 5e-07 29.8 0.0 0.00065 19.6 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT04619.1 - 7.6e-05 22.4 0.0 0.00017 21.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.6 ACT04619.1 - 0.00022 21.8 0.1 0.25 11.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 ACT04619.1 - 0.00028 20.4 0.1 0.00085 18.8 0.1 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain NB-ARC PF00931.22 ACT04619.1 - 0.00057 19.1 0.0 0.0016 17.7 0.0 1.8 1 1 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 ACT04619.1 - 0.0006 20.2 0.0 0.00096 19.6 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ACT04619.1 - 0.00092 19.5 0.0 0.0039 17.4 0.0 2.0 2 1 0 2 2 2 1 AAA domain DUF3987 PF13148.6 ACT04619.1 - 0.0018 17.4 0.0 0.004 16.2 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) RsgA_GTPase PF03193.16 ACT04619.1 - 0.0021 18.0 0.1 0.0055 16.6 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 ACT04619.1 - 0.0039 17.7 0.2 0.0081 16.7 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_27 PF13514.6 ACT04619.1 - 0.0054 16.3 0.0 0.025 14.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain Adeno_IVa2 PF02456.15 ACT04619.1 - 0.0067 15.3 0.1 0.01 14.6 0.1 1.3 1 0 0 1 1 1 1 Adenovirus IVa2 protein MMR_HSR1 PF01926.23 ACT04619.1 - 0.024 14.7 0.1 0.079 13.0 0.1 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 ACT04619.1 - 0.036 13.8 0.0 0.069 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ACT04619.1 - 0.076 13.3 0.0 2.2 8.5 0.0 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 ACT04619.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 ACT04619.1 - 0.12 12.0 0.1 0.22 11.2 0.1 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_15 PF13175.6 ACT04619.1 - 0.13 12.0 0.0 0.26 10.9 0.0 1.4 1 1 0 2 2 2 0 AAA ATPase domain Y_phosphatase3 PF13350.6 ACT04620.1 - 4.1e-63 213.4 0.0 4.6e-63 213.3 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ACT04620.1 - 0.046 13.8 0.3 0.15 12.1 0.0 2.1 2 1 0 2 2 2 0 Inositol hexakisphosphate DUF131 PF01998.17 ACT04621.1 - 0.074 12.7 0.7 0.074 12.7 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF131 APH PF01636.23 ACT04622.1 - 1.4e-21 77.5 2.1 2.1e-21 77.0 2.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ACT04622.1 - 0.00031 20.4 0.0 0.0013 18.4 0.0 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 ACT04622.1 - 0.067 12.4 0.1 1.5 8.0 0.1 2.1 1 1 0 1 1 1 0 Fructosamine kinase Pentapeptide PF00805.22 ACT04623.1 - 3.9e-21 74.3 4.0 3e-11 42.7 0.5 2.6 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ACT04623.1 - 1.6e-07 31.3 0.0 1.2e-06 28.6 0.0 2.2 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ACT04623.1 - 3.1e-06 27.2 0.0 0.0025 17.9 0.0 3.0 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) adh_short PF00106.25 ACT04624.1 - 3.6e-38 131.0 0.6 9e-38 129.7 0.1 1.8 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT04624.1 - 1.6e-29 103.1 0.1 2.7e-29 102.4 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT04624.1 - 2.5e-10 40.6 0.0 3.9e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ACT04624.1 - 2.3e-06 27.6 0.0 4.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ACT04624.1 - 0.00016 20.9 0.0 0.00029 20.0 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Tex_YqgF PF16921.5 ACT04624.1 - 0.088 13.3 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Tex protein YqgF-like domain NmrA PF05368.13 ACT04624.1 - 0.21 11.1 1.5 0.19 11.3 0.3 1.5 2 0 0 2 2 2 0 NmrA-like family TetR_N PF00440.23 ACT04625.1 - 1.7e-13 50.1 0.0 2.9e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_10 PF16295.5 ACT04625.1 - 5.9e-08 33.1 0.0 9.8e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain Ribosomal_S6 PF01250.17 ACT04625.1 - 0.042 14.1 0.3 0.16 12.3 0.1 2.0 1 1 1 2 2 2 0 Ribosomal protein S6 TPR_7 PF13176.6 ACT04626.1 - 0.0056 16.6 0.1 30 4.9 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ACT04626.1 - 0.017 15.4 0.8 6.4 7.1 0.1 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ACT04626.1 - 0.037 14.1 2.8 6.5 7.1 1.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ACT04626.1 - 0.066 14.1 1.7 16 6.6 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ACT04626.1 - 0.092 13.4 0.2 64 4.3 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.9 ACT04626.1 - 0.11 12.2 0.6 1.3 8.7 0.0 2.9 1 1 2 4 4 4 0 26S proteasome subunit RPN7 TPR_1 PF00515.28 ACT04626.1 - 0.25 11.2 6.6 3.6 7.6 0.3 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat HATPase_c_3 PF13589.6 ACT04627.1 - 4.7e-10 39.4 0.0 8.1e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 PF00183.18 ACT04627.1 - 6.6e-10 38.5 0.1 6.6e-10 38.5 0.1 2.6 3 1 1 4 4 4 1 Hsp90 protein HATPase_c PF02518.26 ACT04627.1 - 1.1e-07 32.3 0.0 2.1e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase VanY PF02557.17 ACT04628.1 - 2e-29 102.0 0.7 7.2e-29 100.3 0.7 1.9 1 1 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Tri3 PF07428.11 ACT04628.1 - 0.082 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 15-O-acetyltransferase Tri3 DUF1244 PF06844.11 ACT04628.1 - 0.14 12.3 0.2 0.3 11.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) HATPase_c PF02518.26 ACT04629.1 - 3.1e-17 63.1 0.0 5.5e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT04629.1 - 1.5e-12 47.4 0.3 3.7e-12 46.1 0.3 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 ACT04629.1 - 9.5e-06 25.5 0.0 1.6e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 GHKL domain HAMP PF00672.25 ACT04629.1 - 0.00063 20.1 0.0 0.0023 18.3 0.0 2.0 1 0 0 1 1 1 1 HAMP domain Peptidase_U4 PF03419.13 ACT04629.1 - 0.016 14.6 0.9 0.022 14.1 0.9 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA HATPase_c_2 PF13581.6 ACT04629.1 - 0.067 13.1 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain IBN_N PF03810.19 ACT04629.1 - 0.08 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Importin-beta N-terminal domain Response_reg PF00072.24 ACT04630.1 - 5.5e-32 110.3 0.4 7.8e-32 109.8 0.4 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT04630.1 - 1.1e-26 92.7 0.0 2.8e-26 91.4 0.0 1.7 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal OKR_DC_1_N PF03709.15 ACT04630.1 - 0.0012 19.1 0.0 0.0023 18.2 0.0 1.4 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain DUF3533 PF12051.8 ACT04632.1 - 2.9e-19 69.3 2.5 3.9e-19 68.8 2.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) ABC2_membrane_3 PF12698.7 ACT04632.1 - 1.5e-14 53.9 7.9 4.3e-14 52.4 7.9 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein TetR_C_8 PF14278.6 ACT04633.1 - 1.3e-18 67.0 1.7 4.5e-18 65.3 0.2 2.2 2 1 0 2 2 2 1 Transcriptional regulator C-terminal region TetR_N PF00440.23 ACT04633.1 - 5.8e-07 29.2 0.0 1.1e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family APH PF01636.23 ACT04634.1 - 1.5e-23 84.0 0.0 2.3e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4375 PF14300.6 ACT04635.1 - 0.00062 20.0 0.0 0.00093 19.4 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4375) Bac_luciferase PF00296.20 ACT04636.1 - 2.7e-43 148.6 0.6 3.4e-43 148.3 0.6 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase AhpC-TSA PF00578.21 ACT04637.1 - 3.7e-26 91.5 0.1 4.6e-26 91.2 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ACT04637.1 - 6.3e-24 84.4 0.1 8.5e-24 83.9 0.1 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 ACT04637.1 - 2.1e-14 53.6 0.1 3.3e-14 53.0 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 ACT04637.1 - 3.4e-10 39.8 0.5 2.6e-07 30.6 0.3 2.2 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 ACT04637.1 - 2.1e-06 28.1 0.0 3.5e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain GSHPx PF00255.19 ACT04637.1 - 3.6e-06 26.5 0.0 5.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase SCO1-SenC PF02630.14 ACT04637.1 - 0.00075 19.4 0.0 0.00096 19.1 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_7 PF13899.6 ACT04637.1 - 0.011 15.9 0.0 0.032 14.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like GAD PF02938.14 ACT04637.1 - 0.013 15.7 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 GAD domain YtfJ_HI0045 PF09695.10 ACT04637.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (YtfJ_HI0045) TraF PF13728.6 ACT04637.1 - 0.024 14.4 0.0 0.051 13.4 0.0 1.5 1 1 0 1 1 1 0 F plasmid transfer operon protein TMEM234 PF10639.9 ACT04637.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative transmembrane family 234 DsbD PF02683.15 ACT04638.1 - 6.2e-66 222.3 20.7 7.2e-66 222.1 20.7 1.0 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DUF3853 PF12964.7 ACT04638.1 - 0.045 13.9 0.0 0.078 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) LacI PF00356.21 ACT04638.1 - 0.079 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family Neurensin PF14927.6 ACT04638.1 - 0.6 9.8 9.8 0.35 10.6 0.5 2.8 2 1 1 3 3 3 0 Neurensin SLH PF00395.20 ACT04639.1 - 2.4e-25 88.2 6.3 1.9e-09 37.4 0.2 4.3 4 0 0 4 4 4 3 S-layer homology domain SDF PF00375.18 ACT04641.1 - 3.1e-115 385.3 35.3 4.2e-115 384.9 35.3 1.2 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family DUF2854 PF11016.8 ACT04641.1 - 0.25 11.2 1.6 4.7 7.1 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2854) Vma12 PF11712.8 ACT04641.1 - 4.5 7.4 7.1 1.6 8.8 3.2 2.2 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase CPP1-like PF11833.8 ACT04641.1 - 8.9 5.9 14.3 0.36 10.5 5.8 2.8 2 1 1 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like APH PF01636.23 ACT04642.1 - 6.3e-23 81.9 1.0 1e-22 81.3 0.4 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family APH_6_hur PF04655.14 ACT04642.1 - 0.00082 18.8 0.1 0.0014 18.1 0.1 1.3 1 0 0 1 1 1 1 Aminoglycoside/hydroxyurea antibiotic resistance kinase RIO1 PF01163.22 ACT04642.1 - 0.011 15.4 0.0 0.16 11.6 0.0 2.0 2 0 0 2 2 2 0 RIO1 family Choline_kinase PF01633.20 ACT04642.1 - 0.021 14.4 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-PolyVal PF18762.1 ACT04642.1 - 0.045 13.7 0.1 9.9 6.1 0.0 2.2 2 0 0 2 2 2 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins FA_hydroxylase PF04116.13 ACT04643.1 - 2.4e-20 73.2 12.0 2.4e-20 73.2 12.0 1.5 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily RELT PF12606.8 ACT04643.1 - 0.048 12.7 0.1 0.15 11.1 0.1 1.8 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 UbiA PF01040.18 ACT04643.1 - 0.39 10.0 12.5 0.34 10.2 3.1 2.1 2 0 0 2 2 2 0 UbiA prenyltransferase family DUF4131 PF13567.6 ACT04643.1 - 1.7 8.3 8.9 1.2 8.7 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) MFS_1 PF07690.16 ACT04644.1 - 1.4e-38 132.8 63.5 1.6e-38 132.6 49.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ACT04644.1 - 0.16 11.2 42.7 0.22 10.8 42.7 1.2 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB DUF1077 PF06417.12 ACT04644.1 - 0.25 11.3 3.5 9.4 6.3 0.0 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1077) FlxA PF14282.6 ACT04645.1 - 7.9e-19 67.5 41.7 9.6e-19 67.3 41.7 1.0 1 0 0 1 1 1 1 FlxA-like protein HOOK PF05622.12 ACT04645.1 - 0.0041 15.4 17.0 0.0045 15.2 17.0 1.0 1 0 0 1 1 1 1 HOOK protein Phage_GP20 PF06810.11 ACT04645.1 - 0.0097 15.7 11.6 0.012 15.4 11.6 1.2 1 0 0 1 1 1 1 Phage minor structural protein GP20 APG6_N PF17675.1 ACT04645.1 - 0.011 16.2 14.2 0.015 15.9 14.2 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region Laminin_II PF06009.12 ACT04645.1 - 0.013 15.5 13.4 0.019 15.0 13.4 1.4 1 1 0 1 1 1 0 Laminin Domain II Tropomyosin_1 PF12718.7 ACT04645.1 - 0.026 14.7 12.4 0.026 14.7 12.4 1.7 1 1 1 2 2 2 0 Tropomyosin like V_ATPase_I PF01496.19 ACT04645.1 - 0.027 12.4 14.3 0.028 12.4 14.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ISG65-75 PF11727.8 ACT04645.1 - 0.029 13.6 10.3 0.031 13.5 10.3 1.0 1 0 0 1 1 1 0 Invariant surface glycoprotein Spc7 PF08317.11 ACT04645.1 - 0.098 11.5 13.6 0.11 11.3 13.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein SKA1 PF07160.12 ACT04645.1 - 0.11 12.3 14.3 0.13 12.1 14.3 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 End3 PF12761.7 ACT04645.1 - 0.11 12.7 17.3 0.32 11.1 17.3 1.6 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Atg14 PF10186.9 ACT04645.1 - 0.12 11.4 14.4 0.14 11.2 14.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 OmpH PF03938.14 ACT04645.1 - 0.16 12.3 21.2 0.2 12.0 21.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MRP-L46 PF11788.8 ACT04645.1 - 0.21 12.3 7.3 0.27 12.0 7.3 1.1 1 0 0 1 1 1 0 39S mitochondrial ribosomal protein L46 BBS2_C PF14782.6 ACT04645.1 - 0.24 10.1 10.9 0.29 9.9 10.9 1.3 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal DUF4208 PF13907.6 ACT04645.1 - 0.25 11.8 7.1 0.34 11.4 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) BRI3BP PF14965.6 ACT04645.1 - 0.25 10.8 1.1 0.39 10.2 0.3 1.6 1 1 1 2 2 2 0 Negative regulator of p53/TP53 TMPIT PF07851.13 ACT04645.1 - 0.4 9.9 11.0 0.48 9.6 11.0 1.2 1 0 0 1 1 1 0 TMPIT-like protein PRKG1_interact PF15898.5 ACT04645.1 - 0.54 11.2 18.3 1.4 9.8 8.1 2.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain ACCA PF03255.14 ACT04645.1 - 0.58 10.0 7.7 0.85 9.5 7.7 1.4 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Prefoldin_2 PF01920.20 ACT04645.1 - 0.82 9.6 23.5 2.1 8.3 12.0 2.4 1 1 1 2 2 2 0 Prefoldin subunit Sugarporin_N PF11471.8 ACT04645.1 - 0.91 9.5 10.7 0.042 13.8 4.4 2.2 2 1 0 2 2 1 0 Maltoporin periplasmic N-terminal extension HAUS6_N PF14661.6 ACT04645.1 - 1.1 8.8 13.9 1.3 8.6 13.9 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus ABC_tran_CTD PF16326.5 ACT04645.1 - 1.2 9.4 16.5 0.32 11.3 13.1 1.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain MCU PF04678.13 ACT04645.1 - 1.5 8.9 8.8 1.9 8.6 8.8 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Csm1_N PF18504.1 ACT04645.1 - 1.7 9.0 18.9 3.1 8.2 3.8 2.3 1 1 1 2 2 2 0 Csm1 N-terminal domain CCDC53 PF10152.9 ACT04645.1 - 1.7 9.0 13.6 2.2 8.7 13.6 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF4404 PF14357.6 ACT04645.1 - 1.8 9.3 17.9 3 8.6 17.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) DUF1387 PF07139.11 ACT04645.1 - 1.8 8.2 17.0 2.1 8.0 17.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) 5_nucleotid PF05761.14 ACT04645.1 - 1.9 7.3 11.5 2.2 7.1 11.5 1.0 1 0 0 1 1 1 0 5' nucleotidase family UPF0242 PF06785.11 ACT04645.1 - 2 8.5 17.9 2.5 8.2 17.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4776 PF16003.5 ACT04645.1 - 2 7.3 12.4 2.1 7.2 12.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Seryl_tRNA_N PF02403.22 ACT04645.1 - 2.6 8.3 16.8 13 6.1 16.5 1.9 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 ACT04645.1 - 2.8 7.2 15.9 3.7 6.8 15.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ApoO PF09769.9 ACT04645.1 - 3 7.8 9.8 3.4 7.6 4.1 2.1 1 1 1 2 2 2 0 Apolipoprotein O Allexi_40kDa PF05549.11 ACT04645.1 - 3.8 6.9 14.4 5.8 6.3 14.4 1.3 1 1 0 1 1 1 0 Allexivirus 40kDa protein SprA-related PF12118.8 ACT04645.1 - 4 6.5 24.8 4.4 6.3 24.8 1.1 1 0 0 1 1 1 0 SprA-related family Dsh_C PF12316.8 ACT04645.1 - 4 7.8 15.3 5 7.5 15.3 1.0 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal FemAB PF02388.16 ACT04645.1 - 4.1 6.2 12.1 4.7 6.0 12.1 1.1 1 0 0 1 1 1 0 FemAB family DUF2408 PF10303.9 ACT04645.1 - 4.3 7.9 13.3 8.6 6.9 13.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Fungal_trans_2 PF11951.8 ACT04645.1 - 5 5.8 9.2 8.2 5.1 9.2 1.5 1 1 0 1 1 1 0 Fungal specific transcription factor domain DUF4140 PF13600.6 ACT04645.1 - 5.5 7.5 13.6 0.66 10.5 1.3 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4446 PF14584.6 ACT04645.1 - 5.7 6.9 9.7 10 6.1 9.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) TP53IP5 PF15331.6 ACT04645.1 - 6.4 6.9 14.9 7.2 6.7 14.9 1.0 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF4698 PF15769.5 ACT04645.1 - 7.1 5.6 16.8 9 5.2 16.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) SOBP PF15279.6 ACT04645.1 - 7.4 7.1 13.8 8.2 6.9 13.8 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein SR-25 PF10500.9 ACT04645.1 - 8.5 5.9 21.0 15 5.1 20.8 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DivIC PF04977.15 ACT04645.1 - 9 6.2 20.4 0.22 11.3 2.6 2.5 1 1 1 2 2 2 0 Septum formation initiator Sec62 PF03839.16 ACT04645.1 - 9.1 5.7 10.3 11 5.5 10.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 VIT1 PF01988.19 ACT04645.1 - 9.8 6.0 7.6 11 5.8 7.6 1.1 1 0 0 1 1 1 0 VIT family HATPase_c PF02518.26 ACT04646.1 - 1.5e-22 80.3 0.1 2.3e-22 79.6 0.1 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT04646.1 - 6.1e-15 55.0 0.1 2e-14 53.4 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 ACT04646.1 - 4.1e-08 33.4 0.0 8.4e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 ACT04646.1 - 2e-07 31.2 0.0 3.9e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 ACT04646.1 - 2.1e-06 27.7 0.0 4.4e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 ACT04646.1 - 8.7e-05 22.5 0.0 0.00021 21.2 0.0 1.6 1 0 0 1 1 1 1 PAS domain HATPase_c_5 PF14501.6 ACT04646.1 - 0.00033 20.5 0.0 0.00063 19.6 0.0 1.4 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 ACT04646.1 - 0.018 14.9 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 ACT04646.1 - 0.046 14.0 0.0 0.093 13.0 0.0 1.5 1 0 0 1 1 1 0 PAS fold HPTransfase PF10090.9 ACT04646.1 - 0.07 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Histidine phosphotransferase C-terminal domain Strabismus PF06638.11 ACT04646.1 - 1.1 7.9 4.1 1.9 7.0 4.1 1.3 1 0 0 1 1 1 0 Strabismus protein DUF3995 PF13160.6 ACT04646.1 - 7.9 6.9 20.1 0.048 14.0 5.6 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3995) HisKA_7TM PF16927.5 ACT04647.1 - 1.1e-52 179.2 18.2 1.5e-52 178.8 18.2 1.2 1 0 0 1 1 1 1 N-terminal 7TM region of histidine kinase GGDEF PF00990.21 ACT04647.1 - 8.9e-45 152.3 0.0 1.4e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_8 PF13188.7 ACT04647.1 - 9.1e-07 28.8 1.2 2.8e-06 27.2 0.3 2.1 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 ACT04647.1 - 0.00034 20.8 0.0 0.00063 20.0 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 ACT04647.1 - 0.021 14.8 0.0 0.043 13.8 0.0 1.5 1 0 0 1 1 1 0 PAS fold GGDEF_2 PF17853.1 ACT04647.1 - 0.028 14.7 0.3 0.099 12.9 0.1 1.9 2 0 0 2 2 2 0 GGDEF-like domain PAS_10 PF13596.6 ACT04647.1 - 0.061 13.9 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 PAS domain PAS_7 PF12860.7 ACT04647.1 - 0.12 12.6 0.1 0.44 10.7 0.1 2.0 1 1 0 1 1 1 0 PAS fold DUF1218 PF06749.12 ACT04647.1 - 1.7 9.2 5.5 1.1 9.8 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Methyltransf_11 PF08241.12 ACT04648.1 - 3.4e-23 82.1 0.0 5.3e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT04648.1 - 2e-21 76.5 0.0 3.3e-21 75.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ACT04648.1 - 6.1e-21 75.0 0.0 8.7e-21 74.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ACT04648.1 - 2.8e-16 59.7 0.0 3.6e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ACT04648.1 - 5e-14 52.8 0.0 8.3e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ACT04648.1 - 1.4e-08 34.1 0.0 2e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.18 ACT04648.1 - 1.5e-08 34.3 0.0 1.7e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 ACT04648.1 - 3.7e-06 26.4 0.0 5.8e-06 25.8 0.0 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 ACT04648.1 - 8.2e-05 22.2 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain ADH_zinc_N PF00107.26 ACT04648.1 - 0.00015 21.7 0.0 0.00029 20.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NodS PF05401.11 ACT04648.1 - 0.00023 20.8 0.0 0.00033 20.3 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) PrmA PF06325.13 ACT04648.1 - 0.00044 19.7 0.0 0.00078 18.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 ACT04648.1 - 0.0051 16.4 0.0 0.0072 15.9 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW FtsJ PF01728.19 ACT04648.1 - 0.0097 16.0 0.0 0.036 14.2 0.0 2.0 2 1 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 ACT04648.1 - 0.012 15.1 0.0 0.023 14.1 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_32 PF13679.6 ACT04648.1 - 0.014 15.4 0.0 0.021 14.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain N6_N4_Mtase PF01555.18 ACT04648.1 - 0.017 14.8 0.0 5.9 6.5 0.0 2.1 2 0 0 2 2 2 0 DNA methylase DREV PF05219.12 ACT04648.1 - 0.02 14.0 0.0 0.044 12.9 0.0 1.6 1 1 0 1 1 1 0 DREV methyltransferase TehB PF03848.14 ACT04648.1 - 0.052 13.0 0.0 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB TPMT PF05724.11 ACT04648.1 - 0.063 12.9 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) TetR_C_8 PF14278.6 ACT04649.1 - 1.7e-15 57.0 0.1 5.2e-15 55.4 0.1 1.7 1 0 0 1 1 1 1 Transcriptional regulator C-terminal region TetR_N PF00440.23 ACT04649.1 - 6.2e-09 35.5 0.0 1.1e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family adh_short_C2 PF13561.6 ACT04650.1 - 1.3e-66 224.5 6.8 1.5e-66 224.3 6.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT04650.1 - 3.7e-59 199.5 5.7 4.3e-59 199.2 5.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT04650.1 - 9.3e-14 51.7 1.7 1.3e-13 51.2 1.7 1.1 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ACT04650.1 - 0.00051 20.0 1.7 0.0007 19.5 1.7 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 ACT04650.1 - 0.014 14.8 0.6 0.18 11.3 0.3 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DFP PF04127.15 ACT04650.1 - 0.32 10.8 5.0 0.76 9.6 5.0 1.6 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein LysR_substrate PF03466.20 ACT04651.1 - 4.8e-28 98.0 0.0 7.2e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT04651.1 - 1.1e-17 63.7 0.0 1.8e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Oxidored_nitro PF00148.19 ACT04651.1 - 0.017 13.8 0.0 0.028 13.2 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase HTH_11 PF08279.12 ACT04651.1 - 0.047 13.6 0.0 0.17 11.8 0.0 1.9 1 0 0 1 1 1 0 HTH domain HTH_50 PF18024.1 ACT04651.1 - 0.079 12.6 0.4 0.69 9.6 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain MFS_1 PF07690.16 ACT04652.1 - 3.2e-55 187.5 48.7 3.2e-55 187.5 48.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Response_reg PF00072.24 ACT04653.1 - 1.5e-22 79.9 0.1 3.1e-22 78.9 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT04653.1 - 1.5e-19 69.8 0.0 2.6e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HATPase_c PF02518.26 ACT04654.1 - 7.4e-18 65.1 0.0 1.1e-17 64.5 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ACT04654.1 - 0.013 15.3 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT04654.1 - 0.015 15.3 1.5 0.21 11.6 0.0 3.1 3 1 0 3 3 3 0 His Kinase A (phospho-acceptor) domain DUF998 PF06197.13 ACT04654.1 - 0.025 14.2 0.3 0.037 13.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF998) Phage_holin_3_6 PF07332.11 ACT04654.1 - 0.033 14.2 0.1 0.053 13.6 0.1 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III SPT_ssu-like PF11779.8 ACT04654.1 - 0.087 12.5 0.5 0.29 10.8 0.5 1.9 1 0 0 1 1 1 0 Small subunit of serine palmitoyltransferase-like DUF3611 PF12263.8 ACT04654.1 - 0.13 12.2 0.2 0.2 11.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) HATPase_c_2 PF13581.6 ACT04654.1 - 0.14 12.1 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain FtsX PF02687.21 ACT04655.1 - 1.5e-10 41.4 16.1 1.8e-07 31.5 8.7 6.0 5 1 0 5 5 5 2 FtsX-like permease family MAP17 PF15807.5 ACT04655.1 - 0.066 13.5 0.3 0.8 9.9 0.2 2.6 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 ABC_tran PF00005.27 ACT04656.1 - 1.1e-31 110.2 0.0 1.5e-31 109.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04656.1 - 9e-06 25.7 1.3 0.012 15.5 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ACT04656.1 - 4.9e-05 23.0 0.1 9.6e-05 22.0 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ACT04656.1 - 0.00012 22.0 0.1 0.00021 21.2 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 ACT04656.1 - 0.00016 21.3 0.1 0.045 13.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.7 ACT04656.1 - 0.00017 20.6 0.0 0.023 13.6 0.0 2.1 2 0 0 2 2 2 1 AAA-like domain AAA_30 PF13604.6 ACT04656.1 - 0.00055 19.7 0.1 0.0028 17.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ACT04656.1 - 0.00069 20.2 0.0 0.0018 18.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 ACT04656.1 - 0.0007 19.1 0.4 0.058 12.8 0.1 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ACT04656.1 - 0.00095 19.6 0.3 0.0044 17.4 0.3 1.9 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 ACT04656.1 - 0.0042 17.0 0.1 0.014 15.3 0.0 1.7 1 1 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 ACT04656.1 - 0.011 16.0 0.1 0.076 13.3 0.0 2.2 2 1 1 3 3 3 0 AAA domain AAA_18 PF13238.6 ACT04656.1 - 0.015 15.8 0.0 0.025 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ACT04656.1 - 0.018 15.1 0.0 0.034 14.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_15 PF13175.6 ACT04656.1 - 0.025 14.3 0.0 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 ACT04656.1 - 0.066 13.5 0.0 0.28 11.4 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA PF00004.29 ACT04656.1 - 0.068 13.6 0.1 1.1 9.7 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 ACT04656.1 - 0.091 12.8 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain ATP_bind_1 PF03029.17 ACT04656.1 - 0.11 12.2 0.1 0.22 11.3 0.1 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 ACT04656.1 - 0.12 12.8 0.1 0.29 11.5 0.1 1.7 1 0 0 1 1 1 0 RNA helicase Lipase_GDSL_2 PF13472.6 ACT04657.1 - 9.5e-29 101.1 0.0 1.3e-28 100.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ACT04657.1 - 8.3e-14 52.0 0.0 9.9e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 ACT04657.1 - 1e-05 25.8 0.0 1.7e-05 25.0 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family AP_endonuc_2 PF01261.24 ACT04657.1 - 0.1 12.0 0.5 1.1 8.7 0.5 2.1 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel F_bP_aldolase PF01116.20 ACT04658.1 - 3.3e-104 348.3 0.1 3.7e-104 348.1 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II ThiG PF05690.14 ACT04658.1 - 0.00087 18.7 0.3 0.026 13.8 0.0 2.1 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG 4HFCP_synth PF04476.13 ACT04658.1 - 0.038 13.7 0.1 0.056 13.2 0.1 1.3 1 0 0 1 1 1 0 4-HFC-P synthase HSP70 PF00012.20 ACT04659.1 - 7.5e-132 440.5 0.1 4.2e-116 388.5 0.1 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ACT04659.1 - 2.8e-19 69.1 0.0 7.6e-18 64.4 0.0 2.4 2 1 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 ACT04659.1 - 0.049 12.9 0.1 0.33 10.2 0.0 2.0 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase TPR_2 PF07719.17 ACT04660.1 - 4.8e-35 116.8 60.8 6.2e-05 22.8 1.8 18.2 19 0 0 19 19 19 10 Tetratricopeptide repeat TPR_19 PF14559.6 ACT04660.1 - 1e-29 102.8 50.2 4.1e-07 30.4 4.8 10.9 5 3 7 13 13 13 6 Tetratricopeptide repeat TPR_1 PF00515.28 ACT04660.1 - 2.1e-29 100.1 58.9 3.6e-06 26.5 2.2 16.2 17 0 0 17 17 16 8 Tetratricopeptide repeat TPR_8 PF13181.6 ACT04660.1 - 8.4e-28 94.2 39.4 5.1e-05 23.2 0.8 15.0 16 0 0 16 16 15 6 Tetratricopeptide repeat TPR_16 PF13432.6 ACT04660.1 - 4.5e-25 88.0 28.2 3e-06 27.8 0.0 10.4 6 3 3 11 11 11 8 Tetratricopeptide repeat TPR_14 PF13428.6 ACT04660.1 - 5.2e-25 86.0 50.4 0.021 15.6 0.3 17.5 3 2 16 19 19 19 6 Tetratricopeptide repeat ANAPC3 PF12895.7 ACT04660.1 - 8.7e-21 74.0 55.1 1.8e-05 24.9 0.3 9.9 4 3 7 11 11 11 9 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ACT04660.1 - 4.5e-17 61.5 35.7 3.4e-06 26.6 0.3 11.7 11 2 2 13 13 13 4 TPR repeat TPR_9 PF13371.6 ACT04660.1 - 1.2e-16 60.6 29.6 0.0084 16.2 1.2 8.4 5 3 2 7 7 7 6 Tetratricopeptide repeat TPR_12 PF13424.6 ACT04660.1 - 1.9e-15 56.9 66.3 0.0013 19.0 0.5 12.3 8 4 6 14 14 13 8 Tetratricopeptide repeat TPR_6 PF13174.6 ACT04660.1 - 2.5e-12 46.6 39.6 2.5 8.9 0.2 15.2 17 0 0 17 17 14 1 Tetratricopeptide repeat TPR_17 PF13431.6 ACT04660.1 - 1.4e-11 43.9 41.7 0.0074 16.6 0.4 13.1 15 0 0 15 15 13 3 Tetratricopeptide repeat NARP1 PF12569.8 ACT04660.1 - 2.6e-10 39.9 26.8 1.4e-06 27.6 0.2 6.4 2 1 3 6 6 6 2 NMDA receptor-regulated protein 1 BTAD PF03704.17 ACT04660.1 - 1.3e-07 32.2 39.9 0.6 10.5 0.0 8.5 2 2 6 8 8 8 3 Bacterial transcriptional activator domain DUF3856 PF12968.7 ACT04660.1 - 3.2e-07 30.5 14.0 0.033 14.3 0.5 5.8 2 1 4 6 6 5 2 Domain of Unknown Function (DUF3856) DnaJ PF00226.31 ACT04660.1 - 4.4e-07 29.9 5.5 4.8e-06 26.6 0.1 4.0 4 0 0 4 4 3 1 DnaJ domain PknG_TPR PF16918.5 ACT04660.1 - 7.5e-06 24.9 5.2 0.016 13.9 1.2 3.3 3 0 0 3 3 3 2 Protein kinase G tetratricopeptide repeat ChAPs PF09295.10 ACT04660.1 - 1.9e-05 23.9 14.0 0.017 14.1 1.1 3.5 3 1 1 4 4 4 3 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.6 ACT04660.1 - 2.9e-05 23.8 36.7 0.032 14.3 0.9 10.6 11 1 1 12 12 9 1 Tetratricopeptide repeat TPR_20 PF14561.6 ACT04660.1 - 8.5e-05 22.8 27.3 0.19 12.1 0.3 8.6 3 3 3 9 9 9 2 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ACT04660.1 - 0.00021 20.9 6.3 4.5 6.9 0.1 6.0 4 2 3 7 7 7 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_15 PF13429.6 ACT04660.1 - 0.00055 19.2 29.8 0.009 15.2 5.9 5.4 2 2 2 4 4 4 2 Tetratricopeptide repeat TOM20_plant PF06552.12 ACT04660.1 - 0.03 14.1 5.6 0.78 9.5 1.7 3.5 1 1 2 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 Wzy_C_2 PF11846.8 ACT04660.1 - 0.033 14.1 9.3 0.17 11.8 0.1 4.4 4 1 1 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal TPR_21 PF09976.9 ACT04660.1 - 0.034 13.8 22.9 0.053 13.2 0.2 6.0 4 1 1 6 6 6 0 Tetratricopeptide repeat-like domain PPR PF01535.20 ACT04660.1 - 0.045 14.0 2.1 1.1e+02 3.3 0.0 6.0 7 0 0 7 7 4 0 PPR repeat MukF_M PF17192.4 ACT04660.1 - 0.054 13.2 6.0 0.025 14.3 3.1 1.9 2 0 0 2 2 1 0 MukF middle domain DUF5113 PF17140.4 ACT04660.1 - 0.12 12.1 17.2 0.1 12.4 2.4 5.0 2 1 3 5 5 5 0 Domain of unknown function (DUF5113) DUF982 PF06169.12 ACT04660.1 - 0.41 10.7 2.8 11 6.2 0.1 3.9 4 0 0 4 4 3 0 Protein of unknown function (DUF982) Fis1_TPR_C PF14853.6 ACT04660.1 - 1.5 9.0 25.9 0.68 10.0 0.8 8.2 9 1 0 9 9 7 0 Fis1 C-terminal tetratricopeptide repeat ABC2_membrane_3 PF12698.7 ACT04661.1 - 1.8e-27 96.4 13.5 2.6e-15 56.4 7.9 2.2 2 0 0 2 2 2 2 ABC-2 family transporter protein DUF3533 PF12051.8 ACT04661.1 - 1.6e-17 63.5 8.1 4e-09 35.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3533) ABC2_membrane PF01061.24 ACT04661.1 - 2e-08 33.9 18.8 2e-08 33.9 18.8 2.2 3 1 0 3 3 3 1 ABC-2 type transporter Spc7 PF08317.11 ACT04661.1 - 0.063 12.2 8.2 0.68 8.8 0.7 3.0 1 1 3 4 4 4 0 Spc7 kinetochore protein AKNA PF12443.8 ACT04661.1 - 0.1 13.3 13.2 2.4 8.9 0.5 3.6 2 1 1 3 3 3 0 AT-hook-containing transcription factor YabA PF06156.13 ACT04661.1 - 0.13 12.9 1.0 83 3.9 0.0 4.2 2 2 2 4 4 4 0 Initiation control protein YabA KASH_CCD PF14662.6 ACT04661.1 - 0.85 9.4 9.1 8.3 6.2 3.1 3.2 1 1 3 4 4 4 0 Coiled-coil region of CCDC155 or KASH ERM PF00769.19 ACT04661.1 - 6.3 6.5 8.0 1.3 8.8 0.0 2.7 2 1 1 3 3 3 0 Ezrin/radixin/moesin family SLH PF00395.20 ACT04662.1 - 1.3e-34 117.9 2.4 5.5e-13 48.7 0.0 3.6 4 0 0 4 4 4 3 S-layer homology domain CtsR_C PF17727.1 ACT04662.1 - 0.0024 18.0 0.1 1.5 9.0 0.1 2.5 2 0 0 2 2 2 2 CtsR C-terminal dimerization domain MarR PF01047.22 ACT04662.1 - 0.078 12.9 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 MarR family GntR PF00392.21 ACT04663.1 - 1e-19 69.9 0.5 1.8e-19 69.1 0.5 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family FCD PF07729.12 ACT04663.1 - 1.8e-12 47.8 0.0 2.8e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 FCD domain HTH_24 PF13412.6 ACT04663.1 - 1.3e-05 24.7 0.8 8.2e-05 22.1 0.1 2.5 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.6 ACT04663.1 - 0.00033 20.6 0.1 0.00065 19.6 0.1 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 ACT04663.1 - 0.00045 20.5 0.0 0.0014 19.0 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulator HTH_11 PF08279.12 ACT04663.1 - 0.00099 19.0 0.0 0.0028 17.6 0.0 1.8 1 0 0 1 1 1 1 HTH domain HTH_IclR PF09339.10 ACT04663.1 - 0.0093 15.7 0.3 0.031 14.1 0.1 1.9 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_29 PF13551.6 ACT04663.1 - 0.021 14.8 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix PSII_Pbs31 PF18240.1 ACT04663.1 - 0.024 15.1 0.0 0.043 14.2 0.0 1.4 1 0 0 1 1 1 0 Photosystem II Psb31 protein Sec20 PF03908.13 ACT04663.1 - 0.04 13.8 0.7 1.9 8.5 0.2 2.5 3 0 0 3 3 3 0 Sec20 TFIIE_alpha PF02002.17 ACT04663.1 - 0.049 13.5 0.0 0.76 9.7 0.0 2.3 1 1 1 2 2 2 0 TFIIE alpha subunit HTH_AsnC-type PF13404.6 ACT04663.1 - 0.051 13.4 0.2 0.2 11.5 0.1 2.1 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain PaaX PF07848.12 ACT04663.1 - 0.083 13.1 0.4 0.3 11.3 0.2 1.9 2 0 0 2 2 2 0 PaaX-like protein Metallophos PF00149.28 ACT04664.1 - 5.9e-08 33.5 0.3 1.4e-07 32.2 0.3 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACT04664.1 - 0.00031 21.0 0.1 0.0041 17.3 0.1 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain 2-oxogl_dehyd_N PF16078.5 ACT04664.1 - 0.062 12.9 0.2 0.15 11.6 0.1 1.8 2 0 0 2 2 2 0 2-oxoglutarate dehydrogenase N-terminus DUF927 PF06048.11 ACT04664.1 - 0.16 11.5 0.0 1.5 8.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF927) Metallophos PF00149.28 ACT04665.1 - 2.1e-19 70.9 3.0 2.6e-19 70.5 3.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ACT04665.1 - 1.3e-07 32.0 4.8 2.4e-07 31.1 4.8 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.10 ACT04665.1 - 0.16 10.9 0.1 6.9 5.6 0.0 2.3 1 1 0 2 2 2 0 PhoD-like phosphatase Y_phosphatase3 PF13350.6 ACT04666.1 - 1.3e-59 202.0 0.0 1.4e-59 201.8 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family SBP_bac_8 PF13416.6 ACT04667.1 - 6e-30 105.0 1.6 1.2e-29 104.0 1.6 1.5 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT04667.1 - 1.4e-28 100.8 6.9 2.2e-28 100.1 6.9 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT04668.1 - 2.1e-14 53.7 25.5 2.1e-14 53.7 25.5 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04669.1 - 4.5e-16 59.1 10.3 4.5e-16 59.1 10.3 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component G6B PF15096.6 ACT04670.1 - 0.014 15.2 0.2 0.014 15.2 0.2 1.0 1 0 0 1 1 1 0 G6B family BatA PF07584.11 ACT04670.1 - 0.03 14.7 0.2 0.03 14.7 0.2 1.0 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal DUF4307 PF14155.6 ACT04670.1 - 0.05 13.4 0.1 0.051 13.4 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) DUF4358 PF14270.6 ACT04671.1 - 1.6e-26 92.5 5.1 2.3e-26 92.0 5.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4358) DUF1627 PF07789.12 ACT04671.1 - 0.069 12.8 0.3 0.14 11.8 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1627) SPX PF03105.19 ACT04671.1 - 0.38 10.6 10.7 0.51 10.2 10.7 1.2 1 0 0 1 1 1 0 SPX domain Ndc1_Nup PF09531.10 ACT04671.1 - 1.6 7.3 11.9 2.1 6.9 11.9 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pneumo_att_G PF05539.11 ACT04671.1 - 4.4 6.8 18.5 6.5 6.2 18.5 1.3 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DHHW PF14286.6 ACT04672.1 - 3e-35 122.3 0.6 4.3e-32 111.9 0.2 2.1 1 1 0 2 2 2 2 DHHW protein ALGX PF16822.5 ACT04672.1 - 2e-09 37.5 0.0 2.6e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 SGNH hydrolase-like domain, acetyltransferase AlgX CheW PF01584.19 ACT04672.1 - 0.15 11.7 0.0 0.75 9.4 0.0 2.0 2 0 0 2 2 2 0 CheW-like domain MBOAT PF03062.19 ACT04673.1 - 2.5e-31 109.3 8.9 2.5e-31 109.3 8.9 2.6 2 1 1 3 3 3 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 ACT04673.1 - 5.6e-05 23.3 2.5 0.00016 21.8 2.5 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family DUF4358 PF14270.6 ACT04674.1 - 2.8e-27 95.0 1.9 4e-27 94.5 1.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4358) HSCB_C PF07743.13 ACT04674.1 - 0.057 13.9 0.2 0.13 12.8 0.2 1.6 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain SMAP PF15477.6 ACT04674.1 - 0.12 13.4 0.0 12 6.9 0.2 2.2 2 0 0 2 2 2 0 Small acidic protein family FMN_red PF03358.15 ACT04675.1 - 1.8e-28 99.3 0.0 2.3e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ACT04675.1 - 0.14 11.8 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Flavodoxin-like fold LysR_substrate PF03466.20 ACT04676.1 - 3.1e-43 147.6 0.2 4.7e-43 147.0 0.2 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 ACT04676.1 - 1.8e-21 75.9 1.5 1.6e-20 72.8 1.0 2.5 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 ACT04676.1 - 0.0076 16.0 0.1 0.037 13.8 0.2 2.1 3 0 0 3 3 3 1 PucR C-terminal helix-turn-helix domain MarR_2 PF12802.7 ACT04676.1 - 0.044 13.7 0.1 0.12 12.3 0.1 1.8 1 0 0 1 1 1 0 MarR family SUKH_6 PF14568.6 ACT04676.1 - 0.14 12.5 0.0 0.19 12.1 0.0 1.2 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall adh_short PF00106.25 ACT04677.1 - 2.4e-58 196.8 1.7 2.8e-58 196.6 1.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT04677.1 - 8.1e-55 185.9 2.6 9.9e-55 185.6 2.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT04677.1 - 9.7e-16 58.2 1.8 1.3e-15 57.7 1.8 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACT04677.1 - 0.0041 16.6 0.4 0.035 13.6 0.4 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 ACT04677.1 - 0.037 13.4 0.2 0.06 12.7 0.2 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 ACT04677.1 - 0.064 12.6 0.1 9 5.6 0.1 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase TcpF PF06340.11 ACT04677.1 - 0.11 11.4 0.0 0.29 10.0 0.0 1.7 2 0 0 2 2 2 0 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F Spore_GerAC PF05504.11 ACT04678.1 - 1.3e-22 80.8 0.0 2.7e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal GerA PF03323.13 ACT04679.1 - 8.9e-141 469.5 0.5 1e-140 469.3 0.5 1.0 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein Spore_permease PF03845.13 ACT04680.1 - 1.8e-22 79.6 24.1 1.8e-22 79.6 24.1 1.6 1 1 0 1 1 1 1 Spore germination protein MRAP PF15183.6 ACT04680.1 - 0.024 14.6 0.5 0.024 14.6 0.5 2.9 3 0 0 3 3 3 0 Melanocortin-2 receptor accessory protein family DUF4133 PF13571.6 ACT04680.1 - 0.13 12.7 0.1 0.13 12.7 0.1 5.0 3 2 2 6 6 6 0 Domain of unknown function (DUF4133) DUF1418 PF07214.12 ACT04680.1 - 0.19 11.6 2.6 0.7 9.8 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1418) YfhO PF09586.10 ACT04680.1 - 0.82 7.8 18.9 0.061 11.6 4.1 2.3 2 0 0 2 2 2 0 Bacterial membrane protein YfhO Glycos_transf_1 PF00534.20 ACT04681.1 - 3.8e-05 23.3 0.0 7e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF11 PF01345.18 ACT04682.1 - 8.3e-23 80.5 8.3 1.5e-10 41.2 0.3 5.5 5 1 1 6 6 6 3 Domain of unknown function DUF11 LigB PF02900.18 ACT04683.1 - 1.1e-48 165.7 0.0 1.2e-48 165.5 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Abhydrolase_2 PF02230.16 ACT04684.1 - 3e-19 69.7 0.0 5.1e-19 68.9 0.0 1.4 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Esterase PF00756.20 ACT04684.1 - 1.8e-05 24.5 0.0 0.00012 21.8 0.0 2.1 1 1 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ACT04684.1 - 0.0003 20.1 0.0 0.0025 17.1 0.0 2.1 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ACT04684.1 - 0.0011 19.6 0.0 0.0012 19.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 ACT04684.1 - 0.0018 17.9 0.0 0.0023 17.5 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Palm_thioest PF02089.15 ACT04684.1 - 0.0036 17.2 0.0 0.0042 17.0 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 ACT04684.1 - 0.0054 16.4 0.1 0.032 13.9 0.1 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.13 ACT04684.1 - 0.015 14.9 0.3 0.03 14.0 0.1 1.7 2 1 0 2 2 2 0 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 ACT04684.1 - 0.052 13.4 0.0 0.067 13.0 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF915 PF06028.11 ACT04684.1 - 0.18 11.1 0.0 3.3 7.0 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Cupin_2 PF07883.11 ACT04685.1 - 1.2e-15 57.0 0.3 1.6e-15 56.5 0.3 1.2 1 0 0 1 1 1 1 Cupin domain HTH_19 PF12844.7 ACT04685.1 - 9.4e-13 48.0 0.0 1.3e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 ACT04685.1 - 4.1e-12 46.0 0.1 6.2e-12 45.4 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ACT04685.1 - 7.4e-09 35.8 0.0 1.3e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 ACT04685.1 - 2.9e-07 30.8 0.1 4.8e-07 30.1 0.1 1.4 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain Cupin_1 PF00190.22 ACT04685.1 - 0.00012 21.7 0.0 0.00024 20.8 0.0 1.4 1 0 0 1 1 1 1 Cupin MannoseP_isomer PF01050.18 ACT04685.1 - 0.0016 18.3 0.2 0.0034 17.3 0.1 1.5 1 1 0 1 1 1 1 Mannose-6-phosphate isomerase AraC_binding PF02311.19 ACT04685.1 - 0.0023 17.9 0.0 0.004 17.1 0.0 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain CENP-C_C PF11699.8 ACT04685.1 - 0.0036 17.5 0.0 0.0059 16.8 0.0 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like HTH_25 PF13413.6 ACT04685.1 - 0.0081 16.0 0.1 0.7 9.8 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain Cupin_7 PF12973.7 ACT04685.1 - 0.03 14.2 0.1 0.056 13.4 0.1 1.4 1 0 0 1 1 1 0 ChrR Cupin-like domain HTH_35 PF13693.6 ACT04685.1 - 0.051 13.6 0.0 0.086 12.9 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Cupin_6 PF12852.7 ACT04685.1 - 0.052 13.3 0.0 0.069 12.9 0.0 1.2 1 0 0 1 1 1 0 Cupin HTH_24 PF13412.6 ACT04685.1 - 0.054 13.1 0.1 0.14 11.7 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ACT04685.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 MarR family Auxin_BP PF02041.16 ACT04685.1 - 0.11 12.2 0.2 0.17 11.5 0.2 1.4 1 1 0 1 1 1 0 Auxin binding protein MFS_1 PF07690.16 ACT04686.1 - 8e-49 166.4 55.2 6.4e-47 160.2 53.8 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ACT04686.1 - 0.27 9.7 45.5 0.039 12.5 8.0 3.8 3 1 0 3 3 3 0 MFS/sugar transport protein DUF2613 PF11021.8 ACT04686.1 - 1.1 9.4 0.0 1.1 9.4 0.0 4.0 5 0 0 5 5 5 0 Protein of unknown function (DUF2613) Peripla_BP_2 PF01497.18 ACT04687.1 - 6.2e-30 104.5 1.4 9.6e-30 103.9 1.4 1.3 1 0 0 1 1 1 1 Periplasmic binding protein LPAM_1 PF08139.12 ACT04687.1 - 0.016 15.7 2.6 0.038 14.5 2.6 1.7 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site DinB_2 PF12867.7 ACT04688.1 - 4.3e-15 56.3 1.0 5.2e-15 56.1 1.0 1.1 1 0 0 1 1 1 1 DinB superfamily MDMPI_N PF11716.8 ACT04688.1 - 6.3e-08 33.4 0.1 8.8e-08 32.9 0.1 1.2 1 0 0 1 1 1 1 Mycothiol maleylpyruvate isomerase N-terminal domain DinB PF05163.12 ACT04688.1 - 3.7e-07 30.2 0.5 4.5e-07 29.9 0.5 1.1 1 0 0 1 1 1 1 DinB family DUF1572 PF07609.11 ACT04688.1 - 0.0014 18.4 0.2 0.002 18.0 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1572) DUF664 PF04978.12 ACT04688.1 - 0.0019 18.6 0.1 0.0094 16.4 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF664) Sec5 PF15469.6 ACT04688.1 - 0.0045 16.8 0.0 0.0064 16.3 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec5 Gln-synt_C PF00120.24 ACT04688.1 - 0.1 11.6 0.1 0.63 9.0 0.0 1.9 2 0 0 2 2 2 0 Glutamine synthetase, catalytic domain YjbR PF04237.13 ACT04689.1 - 1e-13 51.6 0.0 1.2e-13 51.4 0.0 1.1 1 0 0 1 1 1 1 YjbR OmdA PF13376.6 ACT04690.1 - 4e-14 52.4 0.1 8.3e-14 51.3 0.1 1.5 1 0 0 1 1 1 1 Bacteriocin-protection, YdeI or OmpD-Associated DUF2267 PF10025.9 ACT04690.1 - 0.0098 16.2 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2267) Strep_SA_rep PF06696.11 ACT04690.1 - 5.8 7.0 8.1 1.3 9.1 0.6 3.5 4 0 0 4 4 4 0 Streptococcal surface antigen repeat AHSA1 PF08327.11 ACT04691.1 - 3.4e-12 46.7 1.1 5.4e-12 46.0 1.1 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein DIM1 PF02966.16 ACT04691.1 - 0.075 12.8 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 Acetyltransf_1 PF00583.25 ACT04692.1 - 5.8e-12 45.9 0.0 7.2e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT04692.1 - 6.7e-06 26.4 0.1 2.4e-05 24.7 0.1 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT04692.1 - 0.00014 21.8 0.0 0.00078 19.4 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT04692.1 - 0.00022 21.1 0.0 0.00054 19.9 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 ACT04692.1 - 0.0066 16.1 0.0 0.73 9.5 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACT04692.1 - 0.17 12.6 0.0 0.26 12.0 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain AHSA1 PF08327.11 ACT04693.1 - 6.4e-25 87.8 0.0 7.3e-25 87.6 0.0 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 ACT04693.1 - 0.00034 20.9 0.2 0.00046 20.5 0.2 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport MerR_1 PF13411.6 ACT04694.1 - 3.1e-19 68.8 0.0 6.9e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT04694.1 - 5e-15 55.0 0.0 9.3e-15 54.1 0.0 1.5 1 0 0 1 1 1 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT04694.1 - 3.6e-07 30.6 7.2 8.5e-07 29.4 7.2 1.7 1 0 0 1 1 1 1 MerR, DNA binding DUF4168 PF13767.6 ACT04694.1 - 0.007 17.5 0.1 0.011 16.9 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4168) RepB PF07506.11 ACT04694.1 - 0.019 15.0 0.4 0.029 14.4 0.4 1.3 1 0 0 1 1 1 0 RepB plasmid partitioning protein CCDC-167 PF15188.6 ACT04694.1 - 1.5 9.2 7.1 0.45 10.9 4.2 1.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 FtsX PF02687.21 ACT04695.1 - 3e-12 46.8 37.4 2.5e-10 40.7 6.0 6.0 6 0 0 6 6 6 2 FtsX-like permease family Saf_2TM PF18303.1 ACT04695.1 - 0.022 14.4 0.1 0.022 14.4 0.1 2.8 3 1 1 4 4 4 0 SAVED-fused 2TM effector domain AcrZ PF10766.9 ACT04695.1 - 3.4 7.3 6.1 6.2 6.5 0.4 2.8 2 0 0 2 2 2 0 Multidrug efflux pump-associated protein AcrZ adh_short_C2 PF13561.6 ACT04696.1 - 5.1e-56 189.9 4.4 5.9e-56 189.6 4.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT04696.1 - 2.4e-49 167.5 4.4 2.8e-49 167.3 4.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT04696.1 - 8.2e-14 51.9 2.7 2.3e-13 50.4 2.7 1.7 1 1 0 1 1 1 1 KR domain Hpr_kinase_C PF07475.12 ACT04696.1 - 0.045 13.3 1.3 1.1 8.7 0.3 2.7 2 1 1 3 3 3 0 HPr Serine kinase C-terminal domain adh_short_C2 PF13561.6 ACT04697.1 - 4.2e-65 219.6 5.4 5.7e-65 219.2 5.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT04697.1 - 2.2e-60 203.5 4.9 3e-60 203.0 4.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT04697.1 - 5.3e-11 42.8 1.0 8.8e-11 42.0 1.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ACT04697.1 - 1.1e-06 28.4 0.3 2e-06 27.4 0.3 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_25 PF13649.6 ACT04697.1 - 0.0036 18.0 0.7 0.0072 17.0 0.2 1.8 2 0 0 2 2 2 1 Methyltransferase domain PALP PF00291.25 ACT04697.1 - 0.0047 16.4 6.5 0.019 14.4 6.6 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme MTS PF05175.14 ACT04697.1 - 0.02 14.5 1.0 0.77 9.3 0.2 2.3 2 0 0 2 2 2 0 Methyltransferase small domain Polysacc_synt_2 PF02719.15 ACT04697.1 - 0.032 13.4 0.2 0.041 13.0 0.2 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein TrkA_N PF02254.18 ACT04697.1 - 0.055 13.7 0.7 0.098 12.9 0.7 1.4 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 ACT04697.1 - 0.12 12.2 3.7 0.095 12.6 1.9 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GntR PF00392.21 ACT04698.1 - 1.5e-17 63.0 0.3 2.5e-17 62.2 0.3 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family TrmB PF01978.19 ACT04698.1 - 0.016 15.1 0.3 0.15 11.9 0.1 2.6 2 1 1 3 3 3 0 Sugar-specific transcriptional regulator TrmB HrcA_DNA-bdg PF03444.15 ACT04698.1 - 0.032 13.9 0.1 0.07 12.8 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding TFIIE_alpha PF02002.17 ACT04698.1 - 0.05 13.5 0.3 0.28 11.0 0.1 2.2 2 0 0 2 2 2 0 TFIIE alpha subunit HTH_Crp_2 PF13545.6 ACT04698.1 - 0.052 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Fe_dep_repress PF01325.19 ACT04698.1 - 0.075 13.2 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Glycos_transf_1 PF00534.20 ACT04699.1 - 3.1e-15 56.1 0.0 1.8e-14 53.7 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ACT04699.1 - 2.1e-13 50.9 0.0 5e-13 49.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 HIF-1 PF11413.8 ACT04699.1 - 6.7 6.2 6.0 1.2 8.6 0.1 2.6 3 0 0 3 3 3 0 Hypoxia-inducible factor-1 Cthe_2159 PF14262.6 ACT04700.1 - 2e-79 266.7 49.6 2.3e-77 259.9 24.6 2.7 2 1 1 3 3 3 2 Carbohydrate-binding domain-containing protein Cthe_2159 DUF4956 PF16316.5 ACT04701.1 - 2.6e-15 56.5 5.3 3.7e-15 56.0 5.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4956) MgtC PF02308.16 ACT04701.1 - 1.7 9.0 14.8 7.6 6.9 13.1 2.2 1 1 1 2 2 2 0 MgtC family LMF1 PF06762.14 ACT04701.1 - 2.3 7.2 9.6 0.057 12.5 0.5 1.9 1 1 1 2 2 2 0 Lipase maturation factor DUF1158 PF06643.11 ACT04701.1 - 4.4 7.9 7.3 7.7 7.1 0.8 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1158) VTC PF09359.10 ACT04702.1 - 2.3e-36 125.6 2.8 5.3e-36 124.4 2.8 1.5 1 1 0 1 1 1 1 VTC domain DUF4468 PF14730.6 ACT04702.1 - 0.083 13.2 0.4 0.24 11.7 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4468) with TBP-like fold Response_reg PF00072.24 ACT04703.1 - 2.5e-29 101.7 0.2 4.1e-29 101.0 0.2 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT04703.1 - 3.1e-18 65.6 0.6 5.8e-18 64.7 0.1 1.7 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal HATPase_c PF02518.26 ACT04704.1 - 9e-27 93.8 0.6 1.3e-25 90.1 0.1 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT04704.1 - 3.2e-14 52.7 0.6 5.4e-14 52.0 0.6 1.4 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 ACT04704.1 - 1.9e-07 30.9 0.0 4.3e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 GHKL domain DHHC PF01529.20 ACT04704.1 - 0.22 11.6 4.7 1 9.4 0.3 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase Sigma_reg_N PF13800.6 ACT04704.1 - 0.97 9.8 6.4 9.4 6.6 1.7 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal NAGPA PF09992.9 ACT04705.1 - 1e-41 143.0 1.3 1.7e-41 142.3 1.3 1.3 1 0 0 1 1 1 1 Phosphodiester glycosidase SpoIIIAH PF12685.7 ACT04705.1 - 0.29 10.9 3.7 0.4 10.5 3.7 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein GtrA PF04138.14 ACT04706.1 - 1.7e-16 60.5 11.1 2.3e-16 60.1 11.1 1.2 1 0 0 1 1 1 1 GtrA-like protein Glycos_transf_2 PF00535.26 ACT04706.1 - 2.5e-16 60.0 0.0 3.6e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 adh_short PF00106.25 ACT04707.1 - 5.5e-53 179.3 0.3 9.6e-53 178.5 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT04707.1 - 1.3e-32 113.2 0.1 1.7e-32 112.9 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ACT04707.1 - 8.5e-08 32.3 0.1 1.5e-07 31.5 0.1 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ACT04707.1 - 0.00029 20.3 0.0 0.0094 15.4 0.0 2.0 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 ACT04707.1 - 0.0035 17.3 0.2 0.0071 16.3 0.2 1.8 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ACT04707.1 - 0.011 15.2 0.0 0.024 14.1 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NmrA PF05368.13 ACT04707.1 - 0.031 13.8 0.1 0.25 10.9 0.2 2.0 2 0 0 2 2 2 0 NmrA-like family RmlD_sub_bind PF04321.17 ACT04707.1 - 0.046 12.8 0.0 0.08 12.0 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain AraC_N PF06719.13 ACT04708.1 - 1.6e-47 160.8 0.4 3.9e-47 159.6 0.1 1.7 2 0 0 2 2 2 1 AraC-type transcriptional regulator N-terminus HTH_18 PF12833.7 ACT04708.1 - 1.9e-23 82.5 0.8 4e-23 81.5 0.5 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04708.1 - 1.9e-18 66.1 0.2 2.5e-08 33.8 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family TetR_N PF00440.23 ACT04708.1 - 0.00061 19.5 0.1 0.012 15.4 0.0 2.8 3 0 0 3 3 3 1 Bacterial regulatory proteins, tetR family HTH_IclR PF09339.10 ACT04708.1 - 0.061 13.1 0.0 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 IclR helix-turn-helix domain Mga PF05043.13 ACT04708.1 - 0.11 13.1 0.0 0.24 12.0 0.0 1.5 1 0 0 1 1 1 0 Mga helix-turn-helix domain HTH_5 PF01022.20 ACT04708.1 - 0.13 12.1 0.0 0.84 9.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Response_reg PF00072.24 ACT04709.1 - 2.7e-21 75.8 0.3 6.3e-21 74.6 0.3 1.6 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 ACT04709.1 - 1.3e-07 31.1 0.2 2.6e-07 30.1 0.2 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACT04709.1 - 0.023 14.4 0.0 0.05 13.3 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 DELLA PF12041.8 ACT04709.1 - 0.04 13.8 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal HTH_40 PF14493.6 ACT04709.1 - 0.08 13.4 0.7 0.17 12.3 0.3 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain EPSP_synthase PF00275.20 ACT04709.1 - 0.1 11.3 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) HATPase_c PF02518.26 ACT04710.1 - 1e-20 74.3 0.0 1.7e-20 73.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 ACT04710.1 - 1.4e-06 28.2 0.2 3.2e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 ACT04710.1 - 6.8e-06 26.0 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT04710.1 - 0.078 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain SBP_bac_1 PF01547.25 ACT04711.1 - 5.4e-29 102.1 11.7 8.4e-29 101.5 11.7 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 ACT04711.1 - 0.011 15.1 1.9 1.1 8.6 0.0 2.5 3 0 0 3 3 3 0 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ACT04711.1 - 0.078 12.7 0.0 0.52 10.0 0.0 2.3 1 1 0 1 1 1 0 Bacterial extracellular solute-binding protein BPD_transp_1 PF00528.22 ACT04712.1 - 2.4e-20 73.0 18.3 2.4e-20 73.0 18.3 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DSRB PF10781.9 ACT04712.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Dextransucrase DSRB BPD_transp_1 PF00528.22 ACT04713.1 - 1.4e-21 77.1 11.4 1.4e-21 77.1 11.4 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Cellulase PF00150.18 ACT04714.1 - 9.7e-32 110.5 0.2 1.4e-31 110.0 0.2 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 ACT04714.1 - 0.076 12.1 0.3 10 5.1 0.0 2.8 3 0 0 3 3 3 0 Glycosyl hydrolases family 2, TIM barrel domain DDE_Tnp_1_6 PF13751.6 ACT04715.1 - 8e-31 106.9 0.6 2.2e-30 105.4 0.6 1.8 1 0 0 1 1 1 1 Transposase DDE domain DUF772 PF05598.11 ACT04715.1 - 3.8e-19 68.5 0.3 2.1e-18 66.1 0.3 2.2 2 0 0 2 2 2 1 Transposase domain (DUF772) DDE_Tnp_1 PF01609.21 ACT04715.1 - 7.2e-18 65.0 0.5 2e-17 63.6 0.5 1.7 1 1 0 1 1 1 1 Transposase DDE domain DUF1664 PF07889.12 ACT04715.1 - 0.39 10.8 2.6 0.54 10.3 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Lysine_decarbox PF03641.14 ACT04716.1 - 6.7e-36 123.3 0.1 8.1e-36 123.0 0.1 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 ACT04716.1 - 1.4e-14 54.0 0.2 1.7e-14 53.7 0.2 1.1 1 0 0 1 1 1 1 SLOG cluster4 family MazG PF03819.17 ACT04717.1 - 1.4e-10 41.2 0.3 2e-10 40.7 0.3 1.2 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain MazG-like PF12643.7 ACT04717.1 - 0.00045 20.4 0.2 0.00068 19.8 0.2 1.3 1 0 0 1 1 1 1 MazG-like family Lipase_3 PF01764.25 ACT04718.1 - 9.8e-27 93.6 0.0 1.4e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ACT04718.1 - 0.014 15.0 0.0 0.11 12.1 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ACT04718.1 - 0.031 14.9 0.0 0.044 14.4 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 ACT04718.1 - 0.05 13.3 0.0 0.077 12.7 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein LPMO_10 PF03067.15 ACT04719.1 - 6.1e-36 124.9 0.0 1.3e-35 123.8 0.0 1.6 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading CBM_5_12 PF02839.14 ACT04719.1 - 6e-09 36.0 15.6 0.00014 22.2 2.1 4.3 3 0 0 3 3 3 2 Carbohydrate binding domain RGI_lyase PF18370.1 ACT04719.1 - 1.8e-08 34.6 0.9 0.0053 17.0 0.1 2.4 2 0 0 2 2 2 2 Rhamnogalacturonan I lyases beta-sheet domain fn3 PF00041.21 ACT04719.1 - 1.1e-07 32.0 11.6 0.0073 16.6 0.1 4.8 3 2 0 3 3 3 2 Fibronectin type III domain CBM_5_12_2 PF14600.6 ACT04719.1 - 1.6e-06 28.0 9.2 0.0012 18.7 0.7 3.0 3 0 0 3 3 3 2 Cellulose-binding domain DUF2369 PF10179.9 ACT04719.1 - 6.9e-06 26.4 0.0 0.092 13.1 0.0 2.5 2 0 0 2 2 2 2 Uncharacterised conserved protein (DUF2369) fn3_2 PF16893.5 ACT04719.1 - 0.00012 22.2 0.0 0.12 12.5 0.0 2.5 2 0 0 2 2 2 2 Fibronectin type III domain WYL PF13280.6 ACT04720.1 - 1.8e-23 83.5 0.0 2.7e-23 82.9 0.0 1.3 1 0 0 1 1 1 1 WYL domain HTH_11 PF08279.12 ACT04720.1 - 1.4e-12 47.3 0.0 2.7e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 HTH domain HTH_DeoR PF08220.12 ACT04720.1 - 3.5e-09 36.3 0.0 6.2e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.20 ACT04720.1 - 0.00016 21.9 0.0 0.00031 21.0 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator HTH_10 PF04967.12 ACT04720.1 - 0.0018 18.1 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 HTH DNA binding domain HrcA_DNA-bdg PF03444.15 ACT04720.1 - 0.015 14.9 0.0 0.045 13.4 0.0 1.7 2 0 0 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding SpoIIID PF12116.8 ACT04720.1 - 0.015 15.4 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Stage III sporulation protein D HTH_Mga PF08280.11 ACT04720.1 - 0.018 15.1 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain GntR PF00392.21 ACT04720.1 - 0.025 14.2 0.1 0.075 12.7 0.1 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_36 PF13730.6 ACT04720.1 - 0.035 14.1 0.0 0.058 13.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 ACT04720.1 - 0.051 13.6 0.0 0.17 11.9 0.0 1.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain MarR_2 PF12802.7 ACT04720.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 MarR family Mga PF05043.13 ACT04720.1 - 0.066 13.8 0.1 0.14 12.8 0.1 1.5 1 0 0 1 1 1 0 Mga helix-turn-helix domain HTH_23 PF13384.6 ACT04720.1 - 0.1 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_ECF PF07638.11 ACT04720.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 ECF sigma factor HTH_IclR PF09339.10 ACT04720.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain PuR_N PF09182.10 ACT04720.1 - 0.18 11.7 0.1 0.35 10.8 0.1 1.4 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal MFS_1 PF07690.16 ACT04721.1 - 1.9e-43 148.8 63.1 4.3e-33 114.7 29.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ACT04721.1 - 2e-09 37.2 38.2 2.5e-09 36.9 38.2 1.1 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 ACT04721.1 - 3.2e-08 32.9 13.4 3.2e-08 32.9 13.4 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 ACT04721.1 - 4.7e-07 28.6 32.9 3.4e-06 25.8 32.9 1.9 1 1 0 1 1 1 1 Transmembrane secretion effector MFS_1_like PF12832.7 ACT04721.1 - 0.0002 20.3 10.2 0.0002 20.3 10.2 2.8 1 1 2 3 3 3 2 MFS_1 like family Beta-lactamase PF00144.24 ACT04722.1 - 8.3e-67 225.8 0.0 1.1e-66 225.4 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase OapA PF04225.12 ACT04723.1 - 0.064 13.4 0.0 0.092 12.9 0.0 1.3 1 0 0 1 1 1 0 Opacity-associated protein A LysM-like domain Phage_holin_2_1 PF04971.12 ACT04724.1 - 0.23 11.5 1.6 0.91 9.6 1.6 2.0 1 0 0 1 1 1 0 Bacteriophage P21 holin S DUF4199 PF13858.6 ACT04724.1 - 2 8.8 11.5 1.3 9.4 2.7 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) DUF2306 PF10067.9 ACT04725.1 - 8.9e-28 97.3 6.6 1.2e-27 96.9 6.6 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2306) DUF420 PF04238.12 ACT04725.1 - 6.9e-05 23.1 5.3 0.022 15.0 1.4 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF420) DUF4231 PF14015.6 ACT04725.1 - 0.76 10.3 3.0 0.67 10.4 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF2157 PF09925.9 ACT04725.1 - 3.5 7.4 9.9 0.12 12.1 1.5 2.5 1 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Acetyltransf_1 PF00583.25 ACT04726.1 - 2.4e-17 63.2 0.1 5.7e-11 42.7 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ACT04726.1 - 2.1e-12 47.3 0.0 1.3e-07 31.9 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ACT04726.1 - 7.5e-07 29.1 0.0 0.0016 18.3 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ACT04726.1 - 7.7e-06 26.6 0.2 0.0073 17.0 0.1 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ACT04726.1 - 0.00021 21.4 0.1 1 9.5 0.0 2.5 2 0 0 2 2 2 2 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 ACT04726.1 - 0.00025 21.1 0.2 0.16 12.0 0.0 3.0 2 2 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 ACT04726.1 - 0.022 14.7 0.0 0.07 13.1 0.0 1.8 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_15 PF17013.5 ACT04726.1 - 0.11 11.9 0.0 0.32 10.5 0.0 1.7 2 0 0 2 2 2 0 Putative acetyl-transferase MCPsignal PF00015.21 ACT04727.1 - 5e-25 88.3 14.8 4.2e-24 85.3 14.5 2.2 1 1 1 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain PAS_4 PF08448.10 ACT04727.1 - 5.3e-14 52.4 0.0 1.6e-13 50.9 0.0 1.8 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 ACT04727.1 - 5.6e-13 49.1 0.0 1.2e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 ACT04727.1 - 1.7e-11 44.3 0.0 3.4e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 ACT04727.1 - 6.6e-09 35.8 0.0 4.5e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 PAS fold Laminin_II PF06009.12 ACT04727.1 - 0.014 15.4 1.2 0.014 15.4 1.2 2.9 2 1 1 3 3 3 0 Laminin Domain II PAS_10 PF13596.6 ACT04727.1 - 0.024 15.2 0.0 0.071 13.7 0.0 1.8 1 0 0 1 1 1 0 PAS domain PAS_8 PF13188.7 ACT04727.1 - 0.042 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 PAS domain Peptidase_M75 PF09375.10 ACT04727.1 - 0.045 13.2 4.2 0.016 14.7 1.8 1.4 2 0 0 2 2 2 0 Imelysin sCache_3_3 PF17202.4 ACT04727.1 - 0.083 13.3 0.0 0.23 11.9 0.0 1.7 1 0 0 1 1 1 0 Single cache domain 3 BLUF PF04940.12 ACT04727.1 - 0.11 12.6 1.2 3 8.1 1.2 2.5 1 1 0 1 1 1 0 Sensors of blue-light using FAD DUF948 PF06103.11 ACT04727.1 - 0.52 10.6 6.0 2.4 8.5 0.2 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF745 PF05335.13 ACT04727.1 - 1.8 8.2 16.6 3.2 7.5 11.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) MerR_1 PF13411.6 ACT04728.1 - 2.7e-13 49.8 0.1 4e-13 49.3 0.1 1.3 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT04728.1 - 2.5e-11 43.1 0.2 4.2e-11 42.4 0.2 1.4 1 0 0 1 1 1 1 MerR family regulatory protein B12-binding PF02310.19 ACT04728.1 - 6.9e-11 42.2 0.0 1.1e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 B12 binding domain B12-binding_2 PF02607.17 ACT04728.1 - 5.6e-10 39.5 0.0 1e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain HTH_23 PF13384.6 ACT04728.1 - 0.081 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_3 PF01381.22 ACT04728.1 - 0.11 12.6 0.0 0.37 10.9 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix HTH_17 PF12728.7 ACT04728.1 - 0.17 12.1 0.1 0.41 10.9 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Epimerase PF01370.21 ACT04729.1 - 2.5e-11 43.5 0.4 4.1e-09 36.3 0.4 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ACT04729.1 - 1.6e-07 31.4 3.4 3e-07 30.5 3.4 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ACT04729.1 - 1.8e-07 30.9 0.2 3.3e-07 30.1 0.2 1.4 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 ACT04729.1 - 0.0013 18.2 0.2 0.0013 18.2 0.2 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase TrkA_N PF02254.18 ACT04729.1 - 0.0016 18.7 0.0 0.027 14.7 0.1 2.2 2 0 0 2 2 2 1 TrkA-N domain RmlD_sub_bind PF04321.17 ACT04729.1 - 0.0024 17.0 0.1 0.0052 15.9 0.1 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain Glyco_transf_4 PF13439.6 ACT04729.1 - 0.007 16.4 0.1 0.1 12.6 0.0 2.1 1 1 1 2 2 2 1 Glycosyltransferase Family 4 3Beta_HSD PF01073.19 ACT04729.1 - 0.0084 15.2 0.0 0.06 12.3 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 ACT04729.1 - 0.011 15.2 0.5 0.011 15.2 0.5 1.6 2 0 0 2 2 2 0 short chain dehydrogenase NAD_binding_4 PF07993.12 ACT04729.1 - 0.011 14.9 0.2 0.017 14.3 0.2 1.3 1 0 0 1 1 1 0 Male sterility protein KR PF08659.10 ACT04729.1 - 0.18 11.7 1.2 0.55 10.1 1.2 1.9 1 1 0 1 1 1 0 KR domain MerR_1 PF13411.6 ACT04730.1 - 5e-19 68.2 0.2 8.4e-19 67.4 0.2 1.4 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 ACT04730.1 - 2.6e-12 46.3 0.0 4e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 MerR family regulatory protein MerR-DNA-bind PF09278.11 ACT04730.1 - 2.2e-09 37.7 1.0 4.4e-09 36.7 0.3 1.8 2 0 0 2 2 2 1 MerR, DNA binding Prefoldin_3 PF13758.6 ACT04730.1 - 0.0036 17.3 2.2 0.01 15.9 0.4 2.1 1 1 1 2 2 2 1 Prefoldin subunit Mod_r PF07200.13 ACT04730.1 - 0.013 15.6 1.9 0.021 14.9 1.8 1.5 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Cas_Cmr5 PF09701.10 ACT04730.1 - 0.016 15.5 2.3 4.6 7.6 0.1 2.7 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_Cmr5) GTP_EFTU PF00009.27 ACT04731.1 - 4.3e-55 186.3 0.0 6.2e-55 185.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ACT04731.1 - 5.7e-19 68.1 0.0 2e-18 66.3 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 ACT04731.1 - 6.9e-18 64.5 0.0 2.5e-17 62.7 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_II PF14492.6 ACT04731.1 - 6.5e-06 26.1 0.0 1.4e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 ACT04731.1 - 2.5e-05 24.3 0.0 4.7e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 ACT04731.1 - 0.0086 16.4 0.1 0.018 15.4 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MFS_2 PF13347.6 ACT04732.1 - 1.8e-67 227.7 29.2 2.2e-67 227.5 29.2 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 ACT04732.1 - 5.4e-25 88.1 40.0 5.4e-25 88.1 40.0 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 ACT04732.1 - 1.6 6.9 7.7 0.13 10.5 0.2 2.6 1 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Helveticin_J PF17312.2 ACT04733.1 - 1.4e-75 254.3 7.5 1.6e-75 254.1 7.5 1.0 1 0 0 1 1 1 1 Bacteriocin helveticin-J DUF4366 PF14283.6 ACT04733.1 - 0.01 15.9 1.3 0.024 14.7 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) MFS18 PF17352.2 ACT04733.1 - 0.031 14.6 0.8 2 8.9 0.0 2.2 2 0 0 2 2 2 0 Male Flower Specific protein 18 Amidohydro_3 PF07969.11 ACT04734.1 - 3.8e-27 95.9 2.0 1.4e-20 74.2 0.4 2.0 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 ACT04734.1 - 6.9e-08 32.2 0.0 9.8e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family FMN_red PF03358.15 ACT04735.1 - 4.4e-15 55.7 0.0 1.2e-14 54.4 0.0 1.6 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ACT04735.1 - 3.1e-13 49.9 0.0 4.3e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 ACT04735.1 - 8.4e-05 22.8 0.0 0.066 13.4 0.0 2.2 2 0 0 2 2 2 2 Flavodoxin domain Flavodoxin_1 PF00258.25 ACT04735.1 - 0.0033 17.6 0.0 0.028 14.7 0.0 2.0 2 0 0 2 2 2 1 Flavodoxin NMT1 PF09084.11 ACT04736.1 - 5.7e-39 134.3 0.7 7.4e-39 133.9 0.7 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 ACT04736.1 - 5.8e-06 26.2 0.0 0.015 15.0 0.0 2.2 1 1 1 2 2 2 2 NMT1-like family LPAM_2 PF13627.6 ACT04736.1 - 1.6 8.7 5.2 3.2 7.7 5.2 1.5 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Amidohydro_3 PF07969.11 ACT04737.1 - 2.2e-33 116.5 1.0 2.8e-22 79.8 0.3 2.1 1 1 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 ACT04737.1 - 8.8e-19 68.0 0.0 3.2e-18 66.2 0.0 1.8 1 1 0 1 1 1 1 Amidohydrolase family FtsQ PF03799.15 ACT04737.1 - 0.0051 17.6 0.0 0.011 16.5 0.0 1.5 1 0 0 1 1 1 1 Cell division protein FtsQ BPD_transp_1 PF00528.22 ACT04738.1 - 8.5e-24 84.3 23.1 8.5e-24 84.3 23.1 1.5 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Corona_NS3b PF03053.14 ACT04738.1 - 4.9 6.9 7.9 0.47 10.2 3.7 1.4 2 0 0 2 2 2 0 ORF3b coronavirus protein FAD_binding_4 PF01565.23 ACT04739.1 - 2.1e-30 105.3 1.0 3.5e-30 104.6 1.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 ACT04739.1 - 0.00017 21.3 0.6 0.0003 20.5 0.0 1.7 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain ABC_tran PF00005.27 ACT04740.1 - 3.4e-31 108.6 0.0 4.6e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 ACT04740.1 - 0.0033 17.1 0.1 0.0066 16.2 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ACT04740.1 - 0.0041 17.0 0.4 0.064 13.1 0.1 2.3 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ACT04740.1 - 0.0045 16.9 0.0 0.0071 16.3 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_15 PF13175.6 ACT04740.1 - 0.0071 16.1 0.0 0.0089 15.8 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ACT04740.1 - 0.0099 16.4 0.1 0.016 15.7 0.1 1.2 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 ACT04740.1 - 0.011 15.2 0.1 0.37 10.2 0.1 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA PF00004.29 ACT04740.1 - 0.016 15.7 0.2 0.042 14.3 0.2 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ACT04740.1 - 0.016 15.1 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_16 PF13191.6 ACT04740.1 - 0.024 15.0 0.0 0.035 14.5 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ACT04740.1 - 0.029 14.7 0.4 0.083 13.2 0.4 1.9 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ACT04740.1 - 0.039 13.7 0.0 0.095 12.4 0.0 1.7 1 1 1 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 ACT04740.1 - 0.046 13.4 0.0 0.066 12.9 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain SbcCD_C PF13558.6 ACT04740.1 - 0.05 13.8 0.1 0.25 11.6 0.1 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_7 PF12775.7 ACT04740.1 - 0.051 13.1 0.0 0.078 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ACT04740.1 - 0.059 13.5 0.1 0.086 12.9 0.1 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Mg_chelatase PF01078.21 ACT04740.1 - 0.064 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 ACT04740.1 - 0.1 11.8 0.1 0.3 10.3 0.1 1.7 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 ACT04740.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase G-alpha PF00503.20 ACT04740.1 - 0.18 11.0 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit Creatininase PF02633.14 ACT04741.1 - 9.1e-65 218.5 0.0 1e-64 218.3 0.0 1.0 1 0 0 1 1 1 1 Creatinine amidohydrolase DeoRC PF00455.22 ACT04742.1 - 2.2e-40 138.2 0.3 3.6e-40 137.5 0.3 1.3 1 0 0 1 1 1 1 DeoR C terminal sensor domain HTH_DeoR PF08220.12 ACT04742.1 - 3.8e-17 61.8 0.1 6.6e-17 61.0 0.1 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 ACT04742.1 - 2e-10 40.5 0.1 4.3e-10 39.4 0.1 1.6 1 0 0 1 1 1 1 HTH domain GntR PF00392.21 ACT04742.1 - 1.1e-08 34.5 0.0 2.1e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family MarR PF01047.22 ACT04742.1 - 5.7e-05 23.0 0.6 0.00031 20.6 0.2 2.2 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.6 ACT04742.1 - 0.00058 19.4 0.8 0.0023 17.5 0.1 2.3 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 ACT04742.1 - 0.0045 16.8 0.2 0.0085 15.9 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_Mga PF08280.11 ACT04742.1 - 0.0087 16.1 0.1 0.019 15.0 0.1 1.5 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain Sigma70_r4 PF04545.16 ACT04742.1 - 0.011 15.3 0.1 0.085 12.4 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.6 ACT04742.1 - 0.018 14.9 0.0 0.055 13.3 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain HTH_7 PF02796.15 ACT04742.1 - 0.073 13.2 0.0 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase Rrf2 PF02082.20 ACT04742.1 - 0.074 13.4 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator FaeA PF04703.12 ACT04742.1 - 0.084 13.3 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 FaeA-like protein HTH_10 PF04967.12 ACT04742.1 - 0.095 12.5 0.1 0.36 10.7 0.0 1.9 2 0 0 2 2 2 0 HTH DNA binding domain HTH_Tnp_Tc3_2 PF01498.18 ACT04742.1 - 0.12 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Transposase PuR_N PF09182.10 ACT04742.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal HTH_Crp_2 PF13545.6 ACT04742.1 - 0.14 12.1 0.3 2.3 8.3 0.1 2.3 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain GyrI-like PF06445.15 ACT04743.1 - 6.6e-19 68.7 0.3 7.8e-19 68.5 0.3 1.0 1 0 0 1 1 1 1 GyrI-like small molecule binding domain Cass2 PF14526.6 ACT04743.1 - 2.4e-17 63.5 0.1 2.7e-17 63.3 0.1 1.0 1 0 0 1 1 1 1 Integron-associated effector binding protein HTH_3 PF01381.22 ACT04744.1 - 2e-17 63.0 0.0 2.9e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 ACT04744.1 - 7.3e-14 51.5 0.0 1.1e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ACT04744.1 - 1.2e-10 41.5 0.0 1.8e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 ACT04744.1 - 6.2e-07 29.8 0.0 9.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain YdaS_antitoxin PF15943.5 ACT04744.1 - 3.3e-05 23.7 0.0 5.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Phage_CI_repr PF07022.13 ACT04744.1 - 8.9e-05 22.5 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain HTH_23 PF13384.6 ACT04744.1 - 0.00029 20.5 0.0 0.00083 19.1 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 ACT04744.1 - 0.011 15.9 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_11 PF08279.12 ACT04744.1 - 0.021 14.8 0.1 0.054 13.4 0.0 1.7 2 0 0 2 2 2 0 HTH domain HTH_25 PF13413.6 ACT04744.1 - 0.066 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4 PF04545.16 ACT04744.1 - 0.077 12.5 0.0 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 Antibiotic_NAT PF02522.14 ACT04746.1 - 1.3e-80 270.4 0.0 1.5e-80 270.2 0.0 1.0 1 0 0 1 1 1 1 Aminoglycoside 3-N-acetyltransferase Sif PF06767.11 ACT04746.1 - 0.25 10.3 0.0 0.37 9.7 0.0 1.1 1 0 0 1 1 1 0 Sif protein DUF1768 PF08719.11 ACT04747.1 - 1.1e-48 165.6 0.0 2.1e-48 164.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) DUF2263 PF10021.9 ACT04747.1 - 5.3e-45 153.4 0.2 7.6e-45 152.9 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) NUDIX PF00293.28 ACT04748.1 - 1.2e-16 61.0 0.2 2.2e-16 60.1 0.2 1.5 1 0 0 1 1 1 1 NUDIX domain Castor1_N PF18700.1 ACT04748.1 - 0.057 13.3 0.0 0.44 10.4 0.0 2.2 2 0 0 2 2 2 0 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain NUDIX PF00293.28 ACT04749.1 - 2.1e-15 56.9 0.0 2.4e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX PF00293.28 ACT04750.1 - 8.6e-15 54.9 0.0 1.2e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain tRNA-synt_2b PF00587.25 ACT04751.1 - 4.1e-23 82.2 0.0 8.7e-23 81.2 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ACT04751.1 - 2.7e-20 72.6 13.9 8.8e-20 71.0 10.7 2.2 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Exonuc_VII_L PF02601.15 ACT04751.1 - 0.0041 16.7 0.6 0.0041 16.7 0.6 1.7 2 0 0 2 2 2 1 Exonuclease VII, large subunit L_lactis_ph-MCP PF06673.11 ACT04751.1 - 0.0076 15.3 0.7 0.014 14.5 0.7 1.3 1 0 0 1 1 1 1 Lactococcus lactis bacteriophage major capsid protein Nucleocap_ssRNA PF11128.8 ACT04751.1 - 0.046 13.4 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 Plant viral coat protein nucleocapsid DUF948 PF06103.11 ACT04751.1 - 0.092 13.0 2.6 1.4 9.2 0.8 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) GAS PF13851.6 ACT04751.1 - 0.32 10.3 12.2 0.059 12.7 7.5 1.9 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 ACT04751.1 - 0.54 9.1 10.6 0.08 11.8 5.8 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein APG6_N PF17675.1 ACT04751.1 - 0.68 10.5 14.4 5.8 7.4 10.5 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region Allexi_40kDa PF05549.11 ACT04751.1 - 0.79 9.2 3.8 1.5 8.2 1.6 2.0 2 0 0 2 2 2 0 Allexivirus 40kDa protein Spectrin PF00435.21 ACT04751.1 - 2.1 8.9 11.1 0.88 10.1 6.5 2.2 2 0 0 2 2 2 0 Spectrin repeat UPF0242 PF06785.11 ACT04751.1 - 3.5 7.7 10.3 0.97 9.5 5.8 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF2203 PF09969.9 ACT04751.1 - 3.6 8.3 5.5 4 8.2 2.9 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Tli4_N PF18443.1 ACT04751.1 - 4.1 7.8 6.4 27 5.1 5.1 2.6 2 1 1 3 3 3 0 Tle cognate immunity protein 4 N-terminal domain Fzo_mitofusin PF04799.13 ACT04751.1 - 4.3 6.9 9.8 3.6 7.1 4.1 2.2 2 0 0 2 2 2 0 fzo-like conserved region DUF1192 PF06698.11 ACT04751.1 - 5.6 7.1 6.8 14 5.9 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Response_reg PF00072.24 ACT04752.1 - 1.8e-24 86.0 0.0 4.5e-24 84.8 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 ACT04752.1 - 4.5e-18 65.8 0.1 1e-17 64.6 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 ACT04752.1 - 8.6e-14 51.7 0.0 6.4e-07 29.6 0.0 2.7 2 0 0 2 2 2 2 PAS domain HisKA PF00512.25 ACT04752.1 - 2.6e-11 43.4 0.0 8.8e-11 41.7 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 ACT04752.1 - 3.5e-10 39.7 0.0 0.0012 18.8 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 ACT04752.1 - 3.4e-09 36.7 0.0 1.6e-05 24.9 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 ACT04752.1 - 3.7e-07 30.4 0.0 0.00024 21.3 0.0 3.5 3 1 0 3 3 3 1 PAS fold HPTransfase PF10090.9 ACT04752.1 - 0.0024 17.7 0.0 0.0044 16.8 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphotransferase C-terminal domain PAS_3 PF08447.12 ACT04752.1 - 0.018 15.3 0.0 4.7 7.6 0.0 2.7 2 0 0 2 2 2 0 PAS fold CheR PF01739.18 ACT04753.1 - 2.3e-42 144.7 0.1 4.2e-42 143.8 0.1 1.4 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.15 ACT04753.1 - 3.3e-12 45.9 1.1 1.1e-11 44.3 1.1 2.0 1 0 0 1 1 1 1 CheR methyltransferase, all-alpha domain Methyltransf_25 PF13649.6 ACT04753.1 - 0.0027 18.4 0.0 7 7.4 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 ACT04753.1 - 0.0032 18.2 0.1 0.46 11.3 0.0 3.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT04753.1 - 0.028 15.1 0.1 4 8.2 0.1 3.0 2 1 0 2 2 2 0 Methyltransferase domain KTSC PF13619.6 ACT04753.1 - 0.052 13.4 0.1 0.15 11.9 0.1 1.8 1 0 0 1 1 1 0 KTSC domain HATPase_c PF02518.26 ACT04754.1 - 3.2e-30 104.9 0.3 7.3e-30 103.8 0.3 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ACT04754.1 - 1e-26 93.3 0.4 3e-26 91.8 0.4 1.9 1 0 0 1 1 1 1 Response regulator receiver domain GAF_2 PF13185.6 ACT04754.1 - 7.9e-18 65.1 0.0 1.6e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 GAF domain HisKA PF00512.25 ACT04754.1 - 1.4e-16 60.3 0.3 1.4e-16 60.3 0.3 4.2 5 0 0 5 5 5 1 His Kinase A (phospho-acceptor) domain 4HB_MCP_1 PF12729.7 ACT04754.1 - 2.4e-14 53.3 3.1 2.4e-14 53.3 3.1 3.5 4 0 0 4 4 4 1 Four helix bundle sensory module for signal transduction CHASE3 PF05227.13 ACT04754.1 - 2.9e-11 43.4 2.6 2.9e-11 43.4 2.6 2.5 2 0 0 2 2 2 1 CHASE3 domain GAF PF01590.26 ACT04754.1 - 2.4e-09 37.9 0.0 5.7e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 GAF domain HAMP PF00672.25 ACT04754.1 - 3e-05 24.3 0.0 8.7e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 HAMP domain GAF_3 PF13492.6 ACT04754.1 - 0.00013 22.3 0.1 0.00031 21.1 0.1 1.7 1 0 0 1 1 1 1 GAF domain OmpH PF03938.14 ACT04754.1 - 0.017 15.5 7.5 0.017 15.5 7.5 2.8 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) GvpL_GvpF PF06386.11 ACT04754.1 - 0.022 14.7 3.6 0.049 13.6 3.6 1.5 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Tropomyosin_1 PF12718.7 ACT04754.1 - 0.075 13.2 15.3 0.046 13.9 13.0 1.8 2 0 0 2 2 1 0 Tropomyosin like Spc7 PF08317.11 ACT04754.1 - 0.13 11.1 17.7 0.076 11.9 14.2 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 ACT04754.1 - 0.14 11.2 8.9 0.28 10.2 8.9 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIC PF04977.15 ACT04754.1 - 0.44 10.3 8.5 2.3 8.1 8.5 2.3 1 0 0 1 1 1 0 Septum formation initiator Jnk-SapK_ap_N PF09744.9 ACT04754.1 - 3.1 8.0 21.1 0.047 13.9 12.3 2.3 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Peptidase_S46 PF10459.9 ACT04754.1 - 8.7 4.9 7.6 0.56 8.8 2.2 1.6 2 0 0 2 2 2 0 Peptidase S46 Exonuc_VII_L PF02601.15 ACT04754.1 - 9.4 5.7 10.9 0.96 8.9 4.8 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit CP_ATPgrasp_2 PF14403.6 ACT04755.1 - 3.6e-155 516.5 0.0 4.3e-155 516.3 0.0 1.0 1 0 0 1 1 1 1 Circularly permuted ATP-grasp type 2 CP_ATPgrasp_1 PF04174.13 ACT04755.1 - 3.8e-142 473.2 0.1 5.9e-142 472.6 0.1 1.3 1 0 0 1 1 1 1 A circularly permuted ATPgrasp Alpha-E PF04168.12 ACT04756.1 - 2.4e-62 211.4 1.2 2.9e-62 211.1 1.2 1.0 1 0 0 1 1 1 1 A predicted alpha-helical domain with a conserved ER motif. Alpha_L_fucos PF01120.17 ACT04757.1 - 2.7e-97 326.3 0.2 3.2e-97 326.1 0.2 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL6 PF14871.6 ACT04757.1 - 8.3e-07 29.2 0.1 2.5e-06 27.7 0.0 1.9 2 0 0 2 2 2 1 Hypothetical glycosyl hydrolase 6 DUF4434 PF14488.6 ACT04757.1 - 0.04 13.9 0.0 0.079 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) HTH_18 PF12833.7 ACT04758.1 - 1.8e-21 76.2 0.7 3e-21 75.5 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04758.1 - 9e-16 57.5 0.0 4.3e-09 36.2 0.0 2.9 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 ACT04758.1 - 3.7e-09 36.6 0.2 6.8e-09 35.7 0.2 1.5 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT04758.1 - 0.0021 17.8 0.0 0.0041 16.8 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 ACT04758.1 - 0.041 13.6 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 Cupin HTH_3 PF01381.22 ACT04758.1 - 0.044 13.8 0.0 0.2 11.7 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix SnoaL_3 PF13474.6 ACT04759.1 - 6.4e-12 45.8 0.0 8e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 ACT04759.1 - 2.1e-11 44.2 0.1 2.5e-11 43.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_4 PF13577.6 ACT04759.1 - 1.1e-09 38.4 0.1 1.7e-09 37.8 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain CaMKII_AD PF08332.10 ACT04759.1 - 6.2e-05 23.1 0.0 8.4e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain SnoaL_2 PF12680.7 ACT04759.1 - 8.4e-05 23.2 0.1 0.00011 22.8 0.1 1.3 1 1 0 1 1 1 1 SnoaL-like domain Lumazine_bd_2 PF12893.7 ACT04759.1 - 0.0071 17.0 0.2 0.023 15.4 0.2 1.8 1 1 0 1 1 1 1 Putative lumazine-binding NTF2 PF02136.20 ACT04759.1 - 0.089 13.4 0.0 0.32 11.6 0.0 1.9 1 1 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain Inj_translocase PF16928.5 ACT04759.1 - 0.11 12.0 0.1 1.8 7.9 0.0 2.1 2 0 0 2 2 2 0 DNA/protein translocase of phage P22 injectosome TerD PF02342.18 ACT04759.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 TerD domain SBP_bac_8 PF13416.6 ACT04760.1 - 4.5e-18 66.1 0.1 1.1e-17 64.8 0.0 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT04760.1 - 3e-11 43.9 1.9 3e-11 43.9 1.9 1.7 2 1 0 2 2 2 1 Bacterial extracellular solute-binding protein 2-oxogl_dehyd_N PF16078.5 ACT04760.1 - 0.22 11.2 1.0 26 4.5 0.0 3.6 4 0 0 4 4 4 0 2-oxoglutarate dehydrogenase N-terminus BPD_transp_1 PF00528.22 ACT04761.1 - 4.2e-10 39.7 21.0 7.4e-09 35.6 21.0 2.4 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Xpo1 PF08389.12 ACT04761.1 - 0.014 15.5 0.0 0.024 14.7 0.0 1.3 1 0 0 1 1 1 0 Exportin 1-like protein BPD_transp_1 PF00528.22 ACT04762.1 - 1.7e-16 60.5 15.6 1.7e-16 60.5 15.6 1.7 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Glyco_hydro_32N PF00251.20 ACT04763.1 - 1.1e-21 77.7 1.0 1.6e-21 77.2 1.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_43 PF04616.14 ACT04763.1 - 6.6e-06 25.6 0.4 1e-05 25.1 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 FGGY_N PF00370.21 ACT04764.1 - 4.5e-64 216.4 0.0 7.3e-64 215.7 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ACT04764.1 - 8.4e-40 136.6 0.1 1.2e-39 136.1 0.1 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 ACT04764.1 - 0.0013 18.3 0.1 0.0091 15.5 0.0 2.0 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family ROK PF00480.20 ACT04765.1 - 1e-54 186.0 0.1 1.4e-54 185.6 0.1 1.2 1 0 0 1 1 1 1 ROK family MarR_2 PF12802.7 ACT04765.1 - 0.008 16.0 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 MarR family Cdc6_C PF09079.11 ACT04765.1 - 0.0082 16.1 0.0 0.021 14.8 0.0 1.7 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain HTH_IclR PF09339.10 ACT04765.1 - 0.031 14.1 0.0 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 IclR helix-turn-helix domain TCR PF03638.15 ACT04765.1 - 0.13 12.6 3.0 0.25 11.7 3.0 1.4 1 0 0 1 1 1 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain MarR PF01047.22 ACT04765.1 - 0.14 12.1 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 MarR family HTH_11 PF08279.12 ACT04765.1 - 1.1 9.2 3.7 0.45 10.5 0.4 2.2 3 0 0 3 3 3 0 HTH domain Mqo PF06039.15 ACT04766.1 - 1.1e-239 796.0 0.0 1.3e-239 795.8 0.0 1.0 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) DAO PF01266.24 ACT04766.1 - 1.9e-08 34.3 0.0 2.7e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 ACT04766.1 - 0.00013 21.2 0.0 0.078 12.1 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 ACT04766.1 - 0.0076 15.0 0.0 0.016 13.9 0.0 1.5 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 ACT04766.1 - 0.0084 16.7 0.0 1.6 9.3 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ACT04766.1 - 0.015 14.4 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 ACT04766.1 - 0.028 13.7 0.0 0.37 10.0 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ACT04766.1 - 0.062 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HxlR PF01638.17 ACT04768.1 - 8.3e-33 112.1 0.4 9.8e-33 111.9 0.4 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.14 ACT04768.1 - 0.0047 16.9 0.0 0.0068 16.3 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family DUF4972 PF16342.5 ACT04768.1 - 0.029 14.0 0.0 0.035 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4972) Replic_Relax PF13814.6 ACT04768.1 - 0.057 13.5 0.0 0.064 13.3 0.0 1.1 1 0 0 1 1 1 0 Replication-relaxation MarR PF01047.22 ACT04768.1 - 0.072 13.0 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 MarR family HTH_34 PF13601.6 ACT04768.1 - 0.1 12.8 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain NAD_binding_10 PF13460.6 ACT04769.1 - 1.3e-19 70.8 0.0 1.5e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ACT04769.1 - 3.4e-05 23.4 0.0 5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ACT04769.1 - 9.5e-05 21.6 0.1 0.00021 20.5 0.0 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain NmrA PF05368.13 ACT04769.1 - 0.00019 21.1 0.0 0.00035 20.2 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family DapB_N PF01113.20 ACT04769.1 - 0.00036 20.7 0.7 0.0007 19.7 0.4 1.6 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus GDP_Man_Dehyd PF16363.5 ACT04769.1 - 0.017 14.5 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ApbA PF02558.16 ACT04769.1 - 0.019 14.6 0.2 0.063 12.9 0.2 1.8 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 ACT04769.1 - 0.049 13.2 0.1 0.087 12.4 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Semialdhyde_dh PF01118.24 ACT04769.1 - 0.062 13.7 0.0 1 9.8 0.0 2.4 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain YCII PF03795.14 ACT04772.1 - 2.4e-15 56.7 0.0 2.9e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain TFA2_Winged_2 PF18121.1 ACT04772.1 - 0.18 11.5 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 Polysacc_deac_1 PF01522.21 ACT04773.1 - 2.5e-30 104.9 0.4 5e-30 104.0 0.1 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase Laminin_II PF06009.12 ACT04774.1 - 0.00015 21.8 2.8 0.00015 21.8 2.8 2.4 2 1 1 3 3 2 1 Laminin Domain II TACC_C PF05010.14 ACT04774.1 - 0.00018 21.4 19.5 0.012 15.4 14.9 2.8 1 1 1 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF3450 PF11932.8 ACT04774.1 - 0.0002 20.8 14.8 0.027 13.8 4.7 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3450) Filament PF00038.21 ACT04774.1 - 0.00021 21.0 15.8 0.004 16.8 4.3 2.3 1 1 1 2 2 2 2 Intermediate filament protein Fungal_TACC PF12709.7 ACT04774.1 - 0.0014 19.0 6.0 0.0014 19.0 6.0 3.5 2 1 2 4 4 3 1 Fungal Transforming acidic coiled-coil (TACC) proteins TPR_MLP1_2 PF07926.12 ACT04774.1 - 0.0024 17.9 16.4 0.0024 17.9 16.4 2.3 2 1 1 3 3 2 1 TPR/MLP1/MLP2-like protein HMMR_N PF15905.5 ACT04774.1 - 0.0027 17.2 23.8 0.0065 16.0 9.1 2.3 1 1 1 2 2 2 1 Hyaluronan mediated motility receptor N-terminal KASH_CCD PF14662.6 ACT04774.1 - 0.0029 17.5 25.3 0.0044 16.9 13.9 2.5 1 1 1 2 2 2 1 Coiled-coil region of CCDC155 or KASH DUF148 PF02520.17 ACT04774.1 - 0.0049 17.0 10.5 0.036 14.2 4.6 2.7 1 1 1 2 2 2 1 Domain of unknown function DUF148 EzrA PF06160.12 ACT04774.1 - 0.0055 14.9 15.9 0.13 10.4 9.8 2.1 1 1 0 2 2 2 2 Septation ring formation regulator, EzrA BRE1 PF08647.11 ACT04774.1 - 0.0066 16.5 8.6 0.0066 16.5 8.6 2.7 1 1 1 2 2 2 1 BRE1 E3 ubiquitin ligase WXG100 PF06013.12 ACT04774.1 - 0.008 16.4 4.5 8.2 6.7 0.1 3.3 2 1 0 2 2 2 0 Proteins of 100 residues with WXG AAA_13 PF13166.6 ACT04774.1 - 0.015 14.0 13.6 0.02 13.6 13.6 1.2 1 0 0 1 1 1 0 AAA domain TBCA PF02970.16 ACT04774.1 - 0.016 15.5 3.3 0.016 15.5 3.3 3.0 1 1 1 2 2 1 0 Tubulin binding cofactor A NPV_P10 PF05531.12 ACT04774.1 - 0.016 15.6 6.6 0.079 13.4 0.6 3.2 2 1 1 3 3 2 0 Nucleopolyhedrovirus P10 protein TMF_DNA_bd PF12329.8 ACT04774.1 - 0.017 15.1 2.3 0.017 15.1 2.3 3.7 3 2 1 4 4 3 0 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 ACT04774.1 - 0.018 13.9 21.8 0.01 14.7 16.1 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4600 PF15372.6 ACT04774.1 - 0.019 15.4 13.9 0.4 11.1 1.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) SlyX PF04102.12 ACT04774.1 - 0.019 15.6 11.2 1.2 9.8 0.2 3.5 1 1 2 3 3 3 0 SlyX ABC_tran_CTD PF16326.5 ACT04774.1 - 0.023 15.0 1.7 0.023 15.0 1.7 3.5 2 1 1 4 4 2 0 ABC transporter C-terminal domain Mod_r PF07200.13 ACT04774.1 - 0.041 14.0 16.4 0.4 10.8 6.0 2.5 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein UPF0242 PF06785.11 ACT04774.1 - 0.041 14.0 28.7 0.26 11.4 7.3 3.3 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF5082 PF16888.5 ACT04774.1 - 0.051 13.9 14.6 7.2 6.9 0.4 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 ACT04774.1 - 0.063 13.8 28.8 0.051 14.1 8.6 2.9 1 1 1 2 2 2 0 Apg6 coiled-coil region Sec2p PF06428.11 ACT04774.1 - 0.066 13.2 0.6 0.066 13.2 0.6 3.4 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p DUF1664 PF07889.12 ACT04774.1 - 0.068 13.2 13.9 0.87 9.6 3.9 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 ACT04774.1 - 0.076 13.3 9.1 0.5 10.6 0.2 3.5 2 1 3 5 5 4 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 ACT04774.1 - 0.077 13.4 10.4 0.63 10.5 0.9 3.6 3 1 1 4 4 3 0 Flagella accessory protein C (FlaC) SLATT_fungal PF18142.1 ACT04774.1 - 0.083 12.9 2.3 0.12 12.4 0.2 2.1 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain SHE3 PF17078.5 ACT04774.1 - 0.092 12.4 18.6 0.34 10.6 18.3 2.0 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 CLZ PF16526.5 ACT04774.1 - 0.095 13.1 16.7 0.071 13.5 3.2 3.3 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels BLOC1_2 PF10046.9 ACT04774.1 - 0.12 12.7 14.7 1.8 8.9 7.8 2.9 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF724 PF05266.14 ACT04774.1 - 0.14 12.0 16.7 0.21 11.4 8.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF724) CENP-F_leu_zip PF10473.9 ACT04774.1 - 0.16 12.0 28.8 0.025 14.6 5.8 2.6 2 1 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Med21 PF11221.8 ACT04774.1 - 0.22 11.8 17.4 0.76 10.0 4.8 2.6 2 1 0 2 2 2 0 Subunit 21 of Mediator complex ADIP PF11559.8 ACT04774.1 - 0.24 11.5 21.0 1.2 9.2 8.9 2.9 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4988 PF16378.5 ACT04774.1 - 0.24 11.1 5.1 1.4 8.6 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function Mce4_CUP1 PF11887.8 ACT04774.1 - 0.26 10.7 2.1 2.1 7.7 0.2 2.1 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Spectrin PF00435.21 ACT04774.1 - 0.32 11.5 15.1 3.1 8.3 4.0 2.9 1 1 2 3 3 3 0 Spectrin repeat V_ATPase_I PF01496.19 ACT04774.1 - 0.32 8.9 13.3 0.13 10.1 7.3 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family THOC7 PF05615.13 ACT04774.1 - 0.34 11.2 14.7 0.63 10.3 13.6 2.0 1 1 1 2 2 2 0 Tho complex subunit 7 DUF2046 PF09755.9 ACT04774.1 - 0.37 10.0 20.2 0.47 9.6 3.5 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) DUF2570 PF10828.8 ACT04774.1 - 0.39 10.6 16.3 0.13 12.1 0.7 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2570) IFT57 PF10498.9 ACT04774.1 - 0.46 9.4 20.0 2 7.3 20.0 2.1 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 FliD_C PF07195.12 ACT04774.1 - 0.46 9.9 11.6 0.099 12.0 0.4 2.5 3 0 0 3 3 2 0 Flagellar hook-associated protein 2 C-terminus GAS PF13851.6 ACT04774.1 - 0.47 9.8 24.5 1.1 8.6 15.2 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding PHM7_cyt PF14703.6 ACT04774.1 - 0.52 10.5 9.0 1.1 9.5 8.6 1.9 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF4407 PF14362.6 ACT04774.1 - 0.53 9.6 11.7 1.6 8.1 11.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5595 PF18077.1 ACT04774.1 - 0.53 10.4 12.4 6.1 7.0 4.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF5595) Spc24 PF08286.11 ACT04774.1 - 0.54 10.5 16.6 0.68 10.2 5.4 3.2 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 Sec34 PF04136.15 ACT04774.1 - 0.8 9.6 13.6 2.8 7.8 5.3 2.8 1 1 3 4 4 4 0 Sec34-like family DUF4200 PF13863.6 ACT04774.1 - 0.81 10.1 27.4 0.23 11.8 10.6 2.9 2 1 1 3 3 2 0 Domain of unknown function (DUF4200) Cluap1 PF10234.9 ACT04774.1 - 0.85 9.0 17.4 0.045 13.2 2.3 2.2 1 1 1 2 2 2 0 Clusterin-associated protein-1 DivIC PF04977.15 ACT04774.1 - 0.87 9.4 16.3 0.24 11.2 6.1 3.4 1 1 2 3 3 3 0 Septum formation initiator GCN5L1 PF06320.13 ACT04774.1 - 1.1 9.4 14.7 0.24 11.5 4.6 3.0 1 1 2 3 3 3 0 GCN5-like protein 1 (GCN5L1) DUF3552 PF12072.8 ACT04774.1 - 1.2 8.6 25.1 0.06 12.8 6.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) YabA PF06156.13 ACT04774.1 - 1.3 9.7 16.1 9.7 6.9 6.2 3.4 1 1 1 2 2 2 0 Initiation control protein YabA Fzo_mitofusin PF04799.13 ACT04774.1 - 1.4 8.4 12.8 4.6 6.8 0.4 2.7 1 1 2 3 3 3 0 fzo-like conserved region Baculo_PEP_C PF04513.12 ACT04774.1 - 1.5 8.9 8.6 8.2 6.5 0.2 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 ACT04774.1 - 1.5 9.0 13.0 9 6.5 7.7 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family GIT_CC PF16559.5 ACT04774.1 - 1.5 8.7 13.1 0.26 11.2 4.3 3.2 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Prefoldin_2 PF01920.20 ACT04774.1 - 1.7 8.6 20.6 1.7 8.6 0.1 3.5 2 1 1 3 3 2 0 Prefoldin subunit DUF4201 PF13870.6 ACT04774.1 - 1.8 8.2 22.4 5.7 6.6 9.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF1515 PF07439.11 ACT04774.1 - 2.1 8.4 6.3 7.4 6.6 1.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1515) Exonuc_VII_L PF02601.15 ACT04774.1 - 2.2 7.8 14.7 4 6.9 14.7 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit DHR10 PF18595.1 ACT04774.1 - 2.2 8.4 27.0 0.53 10.4 10.7 3.0 1 1 2 3 3 2 0 Designed helical repeat protein 10 domain LMBR1 PF04791.16 ACT04774.1 - 2.2 7.1 6.2 2.7 6.8 6.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Fez1 PF06818.15 ACT04774.1 - 2.3 8.6 22.8 0.15 12.5 15.5 2.4 1 1 1 2 2 2 0 Fez1 IFT20 PF14931.6 ACT04774.1 - 2.4 8.3 15.5 7.8 6.7 0.3 2.3 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 Bacillus_HBL PF05791.11 ACT04774.1 - 2.5 7.9 12.4 5.6 6.7 1.4 2.7 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) FapA PF03961.13 ACT04774.1 - 2.8 6.5 16.1 12 4.4 15.9 1.9 1 1 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 ACT04774.1 - 2.9 7.1 13.2 2 7.6 1.5 2.1 1 1 1 2 2 2 0 TMPIT-like protein EMP24_GP25L PF01105.24 ACT04774.1 - 3.5 7.5 12.1 42 4.0 12.1 2.3 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Prominin PF05478.11 ACT04774.1 - 3.5 5.4 10.5 3.2 5.6 9.3 1.3 1 1 0 1 1 1 0 Prominin DUF16 PF01519.16 ACT04774.1 - 4 8.0 16.8 1.1e+03 0.1 14.8 2.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 XhlA PF10779.9 ACT04774.1 - 4.1 7.7 14.4 3.8 7.8 2.2 2.6 2 0 0 2 2 2 0 Haemolysin XhlA Rx_N PF18052.1 ACT04774.1 - 4.9 7.5 10.0 13 6.1 1.3 2.7 2 0 0 2 2 2 0 Rx N-terminal domain CREPT PF16566.5 ACT04774.1 - 4.9 7.3 12.6 4.4 7.5 8.5 2.4 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Jnk-SapK_ap_N PF09744.9 ACT04774.1 - 5 7.3 25.6 1.6 8.9 10.4 2.5 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 MPS2 PF17060.5 ACT04774.1 - 5.1 6.3 14.4 1e+02 2.0 14.2 2.1 1 1 0 1 1 1 0 Monopolar spindle protein 2 Atg14 PF10186.9 ACT04774.1 - 5.1 6.1 16.7 5.3 6.0 5.1 2.2 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FAM76 PF16046.5 ACT04774.1 - 5.9 6.1 22.6 2.2 7.5 9.7 2.1 1 1 1 2 2 2 0 FAM76 protein Lipoprotein_20 PF13942.6 ACT04774.1 - 8 6.3 15.3 0.91 9.4 3.9 2.6 1 1 2 3 3 3 0 YfhG lipoprotein DMPK_coil PF08826.10 ACT04774.1 - 8.6 6.6 17.6 4.7 7.4 10.1 3.4 1 1 2 3 3 3 0 DMPK coiled coil domain like Tropomyosin_1 PF12718.7 ACT04774.1 - 9 6.4 26.1 3.3 7.9 9.5 3.2 1 1 0 2 2 2 0 Tropomyosin like bZIP_1 PF00170.21 ACT04774.1 - 9.9 6.4 15.5 3 8.0 7.3 3.2 1 1 1 2 2 2 0 bZIP transcription factor HTH_18 PF12833.7 ACT04775.1 - 2.2e-23 82.3 0.4 5.4e-23 81.1 0.4 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04775.1 - 7.8e-19 67.3 0.5 9.2e-10 38.4 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Peripla_BP_2 PF01497.18 ACT04775.1 - 2.3e-12 47.0 0.0 3.5e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein HTH_3 PF01381.22 ACT04775.1 - 0.0014 18.6 0.0 0.0045 17.0 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix AraC_binding_2 PF14525.6 ACT04775.1 - 0.0033 17.1 0.0 0.009 15.7 0.0 1.7 1 0 0 1 1 1 1 AraC-binding-like domain HTH_31 PF13560.6 ACT04775.1 - 0.0071 16.7 1.5 0.044 14.1 0.1 3.0 3 1 0 3 3 3 1 Helix-turn-helix domain HTH_23 PF13384.6 ACT04775.1 - 0.0073 16.1 0.1 0.084 12.7 0.0 2.7 2 0 0 2 2 2 1 Homeodomain-like domain AraC_binding PF02311.19 ACT04775.1 - 0.0086 16.0 0.1 0.028 14.3 0.0 1.9 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 ACT04775.1 - 0.027 14.2 0.0 0.074 12.8 0.0 1.7 1 0 0 1 1 1 0 Cupin domain HTH_Crp_2 PF13545.6 ACT04775.1 - 0.043 13.8 0.4 0.28 11.2 0.1 2.5 3 0 0 3 3 2 0 Crp-like helix-turn-helix domain LigB PF02900.18 ACT04775.1 - 0.18 10.8 0.0 0.35 9.9 0.0 1.4 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase Peripla_BP_2 PF01497.18 ACT04776.1 - 2.4e-23 82.9 0.2 3.4e-23 82.4 0.2 1.2 1 0 0 1 1 1 1 Periplasmic binding protein DUF1180 PF06679.12 ACT04776.1 - 0.044 14.2 0.4 0.072 13.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4969 PF16339.5 ACT04776.1 - 0.11 12.9 0.0 0.35 11.2 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4969) DUF3558 PF12079.8 ACT04776.1 - 0.65 10.0 4.5 1.1 9.2 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) RskA PF10099.9 ACT04777.1 - 0.002 18.5 0.4 0.0036 17.6 0.1 1.5 1 1 0 1 1 1 1 Anti-sigma-K factor rskA RE_MjaI PF09568.10 ACT04777.1 - 0.029 14.2 0.8 0.11 12.4 0.0 2.2 3 0 0 3 3 3 0 MjaI restriction endonuclease Involucrin_N PF10583.9 ACT04777.1 - 0.058 14.0 0.2 0.19 12.3 0.0 1.9 2 0 0 2 2 2 0 Involucrin of squamous epithelia N-terminus Sigma70_r4_2 PF08281.12 ACT04778.1 - 5.8e-12 45.1 0.2 1.5e-11 43.8 0.1 1.8 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 ACT04778.1 - 2.6e-09 36.7 0.0 5.5e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Terminase_5 PF06056.12 ACT04778.1 - 0.00046 20.0 0.0 0.00092 19.1 0.0 1.5 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) Sigma70_r4 PF04545.16 ACT04778.1 - 0.0037 16.8 0.1 0.014 14.9 0.1 2.0 1 1 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 ACT04778.1 - 0.0089 15.9 0.0 0.02 14.8 0.0 1.7 2 0 0 2 2 2 1 ECF sigma factor HTH_38 PF13936.6 ACT04778.1 - 0.02 14.6 0.0 0.054 13.3 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_40 PF14493.6 ACT04778.1 - 0.034 14.6 0.1 0.15 12.5 0.0 2.1 2 1 0 2 2 2 0 Helix-turn-helix domain DUF4518 PF15008.6 ACT04778.1 - 0.043 13.0 0.1 0.053 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) UPF0122 PF04297.14 ACT04778.1 - 0.056 13.7 0.2 0.4 11.0 0.0 2.1 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like HTH_29 PF13551.6 ACT04778.1 - 0.063 13.3 0.1 0.2 11.7 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn helix HTH_23 PF13384.6 ACT04778.1 - 0.092 12.6 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain DUF3530 PF12048.8 ACT04779.1 - 0.035 13.5 2.8 0.041 13.3 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Gastrin PF00918.17 ACT04779.1 - 0.062 14.3 3.0 0.075 14.0 3.0 1.1 1 0 0 1 1 1 0 Gastrin/cholecystokinin family O-antigen_lig PF13425.6 ACT04779.1 - 0.28 9.9 1.9 0.32 9.8 1.9 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Zip PF02535.22 ACT04779.1 - 0.63 9.2 4.9 0.72 9.0 4.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter R_equi_Vir PF05526.11 ACT04779.1 - 1.1 9.0 3.8 1.4 8.8 3.8 1.3 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Ureide_permease PF07168.11 ACT04779.1 - 1.1 7.9 3.9 1.2 7.8 3.9 1.0 1 0 0 1 1 1 0 Ureide permease SelP_N PF04592.14 ACT04779.1 - 1.3 8.4 10.8 1.5 8.2 10.8 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Connexin PF00029.19 ACT04779.1 - 2.5 7.8 6.1 3 7.6 6.1 1.2 1 0 0 1 1 1 0 Connexin Conotoxin PF02950.17 ACT04779.1 - 9.8 7.3 6.5 79 4.4 6.5 2.1 1 1 0 1 1 1 0 Conotoxin Sortase PF04203.13 ACT04780.1 - 5e-20 71.6 0.0 8.4e-20 70.8 0.0 1.4 2 0 0 2 2 2 1 Sortase domain LPAM_1 PF08139.12 ACT04780.1 - 0.054 14.0 0.8 0.094 13.2 0.8 1.4 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site AP_endonuc_2 PF01261.24 ACT04781.1 - 5.4e-28 97.9 0.2 6.8e-28 97.5 0.2 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel STAS PF01740.21 ACT04781.1 - 0.12 12.0 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 STAS domain LUC7 PF03194.15 ACT04781.1 - 0.18 11.4 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 LUC7 N_terminus ACT PF01842.25 ACT04781.1 - 2.3 8.1 4.2 0.68 9.8 0.1 2.2 3 0 0 3 3 3 0 ACT domain Methyltransf_28 PF02636.17 ACT04782.1 - 2.2e-06 27.5 0.0 1.1e-05 25.2 0.0 1.9 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase TPR_2 PF07719.17 ACT04782.1 - 0.0013 18.7 0.2 0.082 13.1 0.1 3.4 2 1 0 2 2 2 1 Tetratricopeptide repeat Methyltransf_12 PF08242.12 ACT04782.1 - 0.042 14.6 0.0 0.11 13.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Fis1_TPR_C PF14853.6 ACT04782.1 - 0.045 13.8 0.3 0.15 12.1 0.3 1.9 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 ACT04782.1 - 0.16 11.9 1.2 0.82 9.6 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ACT04782.1 - 2.5 8.9 4.3 14 6.6 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ACT04782.1 - 4.4 8.4 5.6 7.5 7.7 0.1 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TerC PF03741.16 ACT04783.1 - 1.4e-47 161.7 7.2 1.4e-47 161.7 7.2 1.7 2 0 0 2 2 2 1 Integral membrane protein TerC family TssN PF17555.2 ACT04783.1 - 0.032 13.6 0.3 0.032 13.6 0.3 1.7 2 0 0 2 2 2 0 Type VI secretion system, TssN Cupin_2 PF07883.11 ACT04784.1 - 7.3e-16 57.6 0.1 1.1e-15 57.1 0.1 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ACT04784.1 - 1.2e-05 25.0 0.1 1.6e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 ACT04784.1 - 0.0051 16.7 0.2 0.0083 16.0 0.2 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain DNA_alkylation PF08713.11 ACT04785.1 - 9.4e-18 64.7 0.0 1.2e-17 64.4 0.0 1.1 1 0 0 1 1 1 1 DNA alkylation repair enzyme vWA-TerF-like PF10138.9 ACT04785.1 - 0.12 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 vWA found in TerF C terminus Bac_luciferase PF00296.20 ACT04786.1 - 7.9e-60 202.9 1.2 1.5e-59 202.0 1.2 1.4 1 1 0 1 1 1 1 Luciferase-like monooxygenase BPD_transp_1 PF00528.22 ACT04787.1 - 6.3e-28 97.8 10.6 7.7e-28 97.5 7.7 1.9 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04788.1 - 2.1e-27 96.0 10.6 2.1e-27 96.0 10.6 1.6 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF1418 PF07214.12 ACT04788.1 - 0.076 12.9 0.7 0.076 12.9 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) NMT1 PF09084.11 ACT04789.1 - 1.4e-17 64.4 0.1 1.9e-17 63.9 0.1 1.2 1 0 0 1 1 1 1 NMT1/THI5 like OpuAC PF04069.12 ACT04789.1 - 3.4e-14 53.0 0.2 6.1e-14 52.2 0.2 1.3 1 0 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system NMT1_2 PF13379.6 ACT04789.1 - 9.9e-14 51.6 0.2 2.7e-13 50.2 0.2 1.6 1 1 0 1 1 1 1 NMT1-like family Phosphonate-bd PF12974.7 ACT04789.1 - 2.4e-11 43.7 0.0 5.3e-11 42.6 0.0 1.4 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 ACT04789.1 - 1.3e-10 41.1 0.0 2.2e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1_3 PF16868.5 ACT04789.1 - 7.5e-07 28.8 0.4 2.7e-05 23.8 0.0 2.4 2 1 1 3 3 3 1 NMT1-like family Flp_Fap PF04964.14 ACT04789.1 - 0.045 13.6 0.3 0.11 12.4 0.3 1.6 1 0 0 1 1 1 0 Flp/Fap pilin component ABC_tran PF00005.27 ACT04790.1 - 4.3e-33 114.7 0.0 7.3e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ACT04790.1 - 6.3e-06 26.2 0.6 0.0043 16.9 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 ACT04790.1 - 2.5e-05 24.7 0.1 0.00019 21.9 0.1 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ACT04790.1 - 7.5e-05 23.0 0.0 0.00018 21.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ACT04790.1 - 0.0011 18.9 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 ACT04790.1 - 0.0015 18.7 0.1 0.0087 16.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 ACT04790.1 - 0.0033 17.2 0.1 0.006 16.3 0.1 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Rad17 PF03215.15 ACT04790.1 - 0.0039 17.1 0.0 0.0061 16.5 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_29 PF13555.6 ACT04790.1 - 0.0052 16.5 0.1 0.0097 15.6 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ACT04790.1 - 0.018 15.4 0.2 0.029 14.7 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 ACT04790.1 - 0.026 14.8 0.8 0.21 11.8 0.3 2.1 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ACT04790.1 - 0.044 13.0 0.0 0.087 12.0 0.0 1.6 1 1 0 1 1 1 0 NB-ARC domain ABC_ATPase PF09818.9 ACT04790.1 - 0.066 12.0 0.1 0.47 9.2 0.0 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_30 PF13604.6 ACT04790.1 - 0.07 12.8 0.3 0.19 11.5 0.1 1.7 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ACT04790.1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 ACT04790.1 - 0.16 11.9 0.2 16 5.4 0.1 2.2 2 0 0 2 2 2 0 NTPase AAA_15 PF13175.6 ACT04790.1 - 0.19 11.4 0.0 0.31 10.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 ACT04790.1 - 0.24 11.8 0.0 0.44 11.0 0.0 1.4 1 0 0 1 1 1 0 RNA helicase TetR_N PF00440.23 ACT04791.1 - 1.9e-14 53.2 0.1 3.5e-14 52.3 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_AraC PF00165.23 ACT04791.1 - 0.081 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family TetR_C_6 PF13977.6 ACT04791.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 BetI-type transcriptional repressor, C-terminal TetR_C_17 PF17922.1 ACT04791.1 - 0.14 12.3 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Epimerase PF01370.21 ACT04792.1 - 2.9e-07 30.2 0.0 4e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ACT04792.1 - 2.7e-05 24.1 0.0 4e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ACT04792.1 - 0.0015 17.7 0.0 0.025 13.7 0.0 2.1 2 0 0 2 2 2 1 RmlD substrate binding domain KR PF08659.10 ACT04792.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 KR domain HxlR PF01638.17 ACT04793.1 - 1.2e-33 114.8 0.0 1.4e-33 114.5 0.0 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix Rep_fac_C PF08542.11 ACT04793.1 - 0.052 14.0 0.0 0.089 13.2 0.0 1.4 1 1 0 1 1 1 0 Replication factor C C-terminal domain Nitroreductase PF00881.24 ACT04794.1 - 2.6e-21 76.4 0.0 3.2e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 ACT04794.1 - 0.0099 15.5 0.0 0.032 13.8 0.0 1.8 2 0 0 2 2 2 1 Putative TM nitroreductase Profilin PF00235.19 ACT04794.1 - 0.015 15.6 0.1 0.035 14.4 0.1 1.6 2 0 0 2 2 2 0 Profilin SIR2_2 PF13289.6 ACT04794.1 - 0.053 13.6 0.0 0.098 12.8 0.0 1.4 1 0 0 1 1 1 0 SIR2-like domain PTA_PTB PF01515.19 ACT04794.1 - 0.064 12.6 0.3 0.081 12.2 0.3 1.1 1 0 0 1 1 1 0 Phosphate acetyl/butaryl transferase ApbA PF02558.16 ACT04795.1 - 4.9e-13 49.0 0.0 8.2e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 ACT04795.1 - 0.00048 19.4 0.0 0.00094 18.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ACT04795.1 - 0.00091 19.2 2.1 0.0025 17.7 0.1 2.4 2 1 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ACT04795.1 - 0.0011 19.5 0.0 0.0083 16.7 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ACT04795.1 - 0.0013 19.1 0.0 0.0027 18.1 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 ACT04795.1 - 0.11 11.8 0.1 0.22 10.9 0.1 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ACT04795.1 - 0.13 11.8 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Epimerase PF01370.21 ACT04795.1 - 0.15 11.5 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family TetR_N PF00440.23 ACT04796.1 - 6.3e-08 32.3 0.3 1.2e-07 31.4 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_Tnp_1_2 PF13022.6 ACT04796.1 - 0.014 15.5 0.5 0.031 14.4 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase UvrD_C PF13361.6 ACT04796.1 - 0.12 11.7 0.5 0.16 11.3 0.5 1.2 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF2339 PF10101.9 ACT04797.1 - 9e-44 150.1 69.8 1.6e-30 106.4 54.3 2.0 1 1 1 2 2 2 2 Predicted membrane protein (DUF2339) Phage_holin_5_1 PF06946.11 ACT04797.1 - 0.12 12.8 5.2 1.4 9.3 0.6 3.8 3 0 0 3 3 3 0 Bacteriophage A118-like holin, Hol118 PKcGMP_CC PF16808.5 ACT04797.1 - 0.46 10.4 2.7 0.9 9.4 2.7 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SLH PF00395.20 ACT04798.1 - 8.4e-41 137.7 6.1 2.9e-15 56.0 0.2 3.6 3 0 0 3 3 3 3 S-layer homology domain DUF5018 PF16410.5 ACT04798.1 - 3.5e-13 49.0 16.9 2.7e-05 23.1 0.7 5.1 1 1 4 5 5 5 4 Domain of unknown function (DUF5018) PMBR PF09373.10 ACT04798.1 - 0.006 16.7 0.1 2.1 8.6 0.0 3.0 3 0 0 3 3 3 2 Pseudomurein-binding repeat DUF1390 PF07150.11 ACT04798.1 - 0.023 14.4 2.2 7.2 6.3 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1390) HxlR PF01638.17 ACT04799.1 - 7.7e-33 112.2 0.3 8.9e-33 112.0 0.3 1.0 1 0 0 1 1 1 1 HxlR-like helix-turn-helix MarR PF01047.22 ACT04799.1 - 0.014 15.3 0.1 0.023 14.6 0.1 1.3 1 0 0 1 1 1 0 MarR family DoxX_2 PF13564.6 ACT04800.1 - 1.6e-21 76.4 12.0 1.8e-21 76.2 12.0 1.0 1 0 0 1 1 1 1 DoxX-like family adh_short PF00106.25 ACT04801.1 - 4.1e-41 140.6 0.0 5.8e-41 140.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ACT04801.1 - 5.9e-29 101.3 0.1 7.4e-29 101.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ACT04801.1 - 8.5e-07 28.7 0.2 1.9e-06 27.5 0.2 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ACT04801.1 - 3.7e-05 23.7 0.0 8.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ACT04801.1 - 4.3e-05 23.5 0.2 6.3e-05 22.9 0.1 1.3 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ACT04801.1 - 0.015 14.8 0.1 0.028 13.8 0.1 1.6 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF1776 PF08643.10 ACT04801.1 - 0.015 14.7 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF2064 PF09837.9 ACT04801.1 - 0.03 14.1 0.2 3.7 7.4 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2064) TetR_C_21 PF17926.1 ACT04802.1 - 9e-26 90.2 0.0 1.3e-25 89.7 0.0 1.2 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 ACT04802.1 - 8.3e-12 44.7 0.1 1.6e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family APH PF01636.23 ACT04803.1 - 6.1e-29 101.6 0.2 7.8e-29 101.3 0.2 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Sigma70_r2 PF04542.14 ACT04804.1 - 2.4e-14 52.8 0.3 4.8e-14 51.9 0.3 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 ACT04804.1 - 7.4e-11 41.6 0.1 1.4e-10 40.7 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 ACT04804.1 - 0.00079 18.9 0.0 0.0016 17.9 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 SnoaL_2 PF12680.7 ACT04804.1 - 0.032 14.9 0.0 0.095 13.3 0.0 1.9 1 0 0 1 1 1 0 SnoaL-like domain DUF4440 PF14534.6 ACT04804.1 - 0.036 14.5 0.1 0.1 13.0 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4440) DoxX_2 PF13564.6 ACT04805.1 - 1e-15 57.7 6.8 1.2e-15 57.5 6.8 1.0 1 0 0 1 1 1 1 DoxX-like family Response_reg PF00072.24 ACT04806.1 - 5e-22 78.2 0.0 2.1e-21 76.1 0.0 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HTH_18 PF12833.7 ACT04806.1 - 4.6e-20 71.7 0.1 1.1e-19 70.4 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04806.1 - 6.8e-15 54.7 0.4 2.7e-06 27.3 0.1 2.7 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family FAT PF02259.23 ACT04806.1 - 0.017 14.4 2.0 0.12 11.5 0.0 2.5 2 1 0 3 3 3 0 FAT domain UTP15_C PF09384.10 ACT04806.1 - 0.091 12.4 3.4 0.14 11.9 0.1 2.5 3 0 0 3 3 3 0 UTP15 C terminal CENP-C_C PF11699.8 ACT04806.1 - 0.14 12.4 0.1 0.32 11.2 0.1 1.5 1 0 0 1 1 1 0 Mif2/CENP-C like BPD_transp_1 PF00528.22 ACT04807.1 - 3.5e-21 75.8 12.9 3.5e-21 75.8 12.9 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component COX7C PF02935.16 ACT04807.1 - 0.17 12.2 3.2 0.64 10.3 3.2 2.0 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc ApoO PF09769.9 ACT04807.1 - 1.9 8.4 4.0 0.42 10.6 0.5 1.7 2 0 0 2 2 2 0 Apolipoprotein O BPD_transp_1 PF00528.22 ACT04808.1 - 6.1e-10 39.1 36.5 4.7e-09 36.2 36.5 2.0 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_1 PF01547.25 ACT04809.1 - 9e-32 111.3 9.7 1.5e-31 110.5 9.7 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 ACT04809.1 - 3.8e-29 102.4 5.1 5.4e-29 101.9 5.1 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein His_kinase PF06580.13 ACT04810.1 - 1.7e-22 79.5 0.0 5.7e-22 77.8 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase dCache_1 PF02743.18 ACT04810.1 - 3.4e-21 76.2 9.6 3.4e-21 76.2 9.6 2.1 2 0 0 2 2 2 1 Cache domain HATPase_c PF02518.26 ACT04810.1 - 9.8e-10 38.9 0.5 4e-09 37.0 0.0 2.2 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 ACT04810.1 - 1.6e-07 31.6 0.0 3.6e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 ACT04810.1 - 0.0039 17.0 0.2 0.014 15.3 0.0 2.0 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ACT04810.1 - 0.007 16.3 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain DHHC PF01529.20 ACT04810.1 - 2.3 8.3 4.4 3.6 7.7 1.0 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase DHDPS PF00701.22 ACT04811.1 - 2.1e-64 217.0 0.0 2.4e-64 216.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family nlz1 PF12402.8 ACT04811.1 - 0.1 13.0 0.0 0.4 11.2 0.0 2.0 2 0 0 2 2 2 0 NocA-like zinc-finger protein 1 SBP_bac_1 PF01547.25 ACT04812.1 - 1.3e-24 87.8 15.8 2.5e-24 86.8 15.8 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Oxidored_molyb PF00174.19 ACT04812.1 - 0.035 13.7 0.1 0.17 11.5 0.0 2.1 3 0 0 3 3 3 0 Oxidoreductase molybdopterin binding domain BPD_transp_1 PF00528.22 ACT04813.1 - 1.2e-15 57.7 19.8 1.2e-15 57.7 19.8 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04814.1 - 3.6e-19 69.2 11.8 3.6e-19 69.2 11.8 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component NanE PF04131.14 ACT04815.1 - 9.6e-71 236.9 0.1 1.1e-70 236.7 0.1 1.0 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase NMO PF03060.15 ACT04815.1 - 1e-07 31.7 0.0 1.5e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 ACT04815.1 - 1.7e-06 27.7 0.0 3.6e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 ACT04815.1 - 7.1e-06 25.5 1.5 0.00064 19.1 0.1 2.9 2 1 1 3 3 3 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 ACT04815.1 - 4.4e-05 22.6 0.0 9.3e-05 21.6 0.0 1.4 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain TMP-TENI PF02581.17 ACT04815.1 - 0.0005 19.4 0.1 0.0018 17.6 0.0 1.9 3 0 0 3 3 3 1 Thiamine monophosphate synthase Dus PF01207.17 ACT04815.1 - 0.00052 19.2 0.0 0.0022 17.2 0.0 1.8 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) IGPS PF00218.21 ACT04815.1 - 0.00081 18.6 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase Trp_syntA PF00290.20 ACT04815.1 - 0.0026 16.7 0.0 0.0053 15.6 0.0 1.5 2 0 0 2 2 2 1 Tryptophan synthase alpha chain DHO_dh PF01180.21 ACT04815.1 - 0.0036 16.6 0.5 0.23 10.6 0.0 2.1 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase G3P_antiterm PF04309.12 ACT04815.1 - 0.096 12.1 0.0 0.23 10.8 0.0 1.7 1 1 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator ROK PF00480.20 ACT04816.1 - 5.8e-54 183.6 0.5 7.9e-54 183.1 0.5 1.2 1 0 0 1 1 1 1 ROK family Glucokinase PF02685.16 ACT04816.1 - 8.6e-07 28.2 0.2 6.8e-06 25.3 0.2 2.1 1 1 0 1 1 1 1 Glucokinase BcrAD_BadFG PF01869.20 ACT04816.1 - 0.0094 15.5 0.3 3.8 6.9 0.1 2.1 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family Pan_kinase PF03309.14 ACT04816.1 - 0.0098 15.7 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Type III pantothenate kinase SIS PF01380.22 ACT04817.1 - 7.1e-25 87.4 0.2 1.1e-24 86.7 0.2 1.3 1 0 0 1 1 1 1 SIS domain HTH_6 PF01418.17 ACT04817.1 - 3.1e-24 84.7 0.0 3.1e-24 84.7 0.0 2.1 3 0 0 3 3 3 1 Helix-turn-helix domain, rpiR family SIS_2 PF13580.6 ACT04817.1 - 1.1e-08 35.1 0.7 4.8e-06 26.7 0.4 2.5 1 1 1 2 2 2 2 SIS domain Transketolase_C PF02780.20 ACT04817.1 - 0.03 14.2 0.0 0.64 9.9 0.1 2.6 3 0 0 3 3 3 0 Transketolase, C-terminal domain HTH_IclR PF09339.10 ACT04817.1 - 0.052 13.3 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF2529 PF10740.9 ACT04817.1 - 0.058 13.0 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) DUF4284 PF14112.6 ACT04817.1 - 0.065 14.2 0.4 0.45 11.5 0.1 2.2 2 1 0 2 2 2 0 Immunity protein 22 DUF386 PF04074.12 ACT04818.1 - 2.9e-41 140.8 0.0 3.2e-41 140.7 0.0 1.0 1 0 0 1 1 1 1 YhcH/YjgK/YiaL GerE PF00196.19 ACT04819.1 - 5e-15 54.8 0.1 1.1e-14 53.7 0.1 1.6 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ACT04819.1 - 0.0029 17.2 0.0 0.0056 16.3 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 ACT04819.1 - 0.025 14.4 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain ADH_zinc_N PF00107.26 ACT04820.1 - 6.1e-26 90.9 1.0 1.1e-25 90.1 1.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ACT04820.1 - 1.2e-24 86.3 1.9 2.5e-24 85.2 1.9 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 ACT04820.1 - 2.4e-08 33.7 0.9 5.6e-08 32.5 0.9 1.5 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ACT04820.1 - 2.2e-05 25.5 0.0 5e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase PALP PF00291.25 ACT04820.1 - 0.0043 16.5 0.7 0.0068 15.8 0.7 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TrkA_N PF02254.18 ACT04820.1 - 0.0081 16.4 1.5 0.013 15.7 1.5 1.3 1 0 0 1 1 1 1 TrkA-N domain AlaDh_PNT_C PF01262.21 ACT04820.1 - 0.0091 15.3 2.8 0.0091 15.3 2.8 2.1 1 1 1 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 ACT04820.1 - 0.019 14.5 0.3 0.032 13.8 0.3 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ThiF PF00899.21 ACT04820.1 - 0.03 13.7 0.8 0.05 12.9 0.8 1.3 1 0 0 1 1 1 0 ThiF family ADH_N_2 PF16884.5 ACT04820.1 - 0.084 12.8 0.7 0.24 11.3 0.1 2.0 2 1 0 2 2 2 0 N-terminal domain of oxidoreductase HTH_40 PF14493.6 ACT04820.1 - 0.11 13.0 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain GCD14 PF08704.10 ACT04820.1 - 0.19 11.4 0.1 0.41 10.3 0.0 1.5 1 1 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit MFS_1 PF07690.16 ACT04821.1 - 1.1e-52 179.1 52.2 1.1e-52 179.1 52.2 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT04821.1 - 2.1e-15 56.6 45.0 9.8e-12 44.5 13.7 3.6 2 1 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 ACT04821.1 - 1.3e-13 50.3 23.9 1.7e-13 49.9 23.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 ACT04821.1 - 0.00077 18.1 10.3 0.00077 18.1 10.3 3.8 2 2 0 3 3 3 2 MFS/sugar transport protein YfhO PF09586.10 ACT04821.1 - 8.5 4.5 12.6 0.19 9.9 3.7 2.1 1 1 1 2 2 2 0 Bacterial membrane protein YfhO WYL PF13280.6 ACT04822.1 - 4.8e-38 130.9 1.9 7.1e-38 130.3 1.9 1.3 1 0 0 1 1 1 1 WYL domain HTH_11 PF08279.12 ACT04822.1 - 3.5e-13 49.3 0.2 6.6e-13 48.4 0.2 1.4 1 0 0 1 1 1 1 HTH domain HTH_DeoR PF08220.12 ACT04822.1 - 1.6e-06 27.8 0.2 8.1e-06 25.5 0.1 2.2 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.20 ACT04822.1 - 0.00076 19.8 0.0 0.0016 18.8 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator TrmB PF01978.19 ACT04822.1 - 0.0019 18.0 0.1 0.0041 17.0 0.1 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_29 PF13551.6 ACT04822.1 - 0.0079 16.2 0.4 0.025 14.6 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 ACT04822.1 - 0.021 14.6 0.4 0.076 12.8 0.4 2.0 1 0 0 1 1 1 0 Homeodomain-like domain Mga PF05043.13 ACT04822.1 - 0.036 14.6 0.0 0.1 13.2 0.0 1.7 1 0 0 1 1 1 0 Mga helix-turn-helix domain HTH_22 PF13309.6 ACT04822.1 - 0.12 12.5 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 HTH domain HTH_Mga PF08280.11 ACT04822.1 - 0.12 12.4 0.0 0.62 10.1 0.0 2.0 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_36 PF13730.6 ACT04822.1 - 0.12 12.3 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain FUR PF01475.19 ACT04822.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Ferric uptake regulator family adh_short_C2 PF13561.6 ACT04823.1 - 2.4e-54 184.4 0.2 2.8e-54 184.2 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ACT04823.1 - 4.1e-46 156.9 0.4 4.8e-46 156.7 0.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ACT04823.1 - 5.7e-10 39.4 0.3 9.1e-10 38.7 0.3 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ACT04823.1 - 2.3e-05 24.4 0.8 3.4e-05 23.8 0.8 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Enoyl_reductase PF12241.8 ACT04823.1 - 0.012 15.0 0.0 0.097 12.0 0.1 2.0 2 0 0 2 2 2 0 Trans-2-enoyl-CoA reductase catalytic region Epimerase PF01370.21 ACT04823.1 - 0.022 14.2 0.3 0.054 12.9 0.3 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ACT04823.1 - 0.03 13.4 0.1 0.15 11.0 0.1 1.8 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Tcp11 PF05794.13 ACT04823.1 - 0.14 11.2 0.0 0.14 11.2 0.0 1.0 1 0 0 1 1 1 0 T-complex protein 11 PTS-HPr PF00381.19 ACT04824.1 - 1.4e-26 92.6 0.0 1.5e-26 92.4 0.0 1.0 1 0 0 1 1 1 1 PTS HPr component phosphorylation site MazE_antitoxin PF04014.18 ACT04824.1 - 0.085 12.8 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin PEP-utilizers_C PF02896.18 ACT04825.1 - 1.2e-122 408.6 0.0 1.7e-122 408.1 0.0 1.2 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PEP-utilisers_N PF05524.13 ACT04825.1 - 1.2e-31 109.3 1.5 4.5e-31 107.4 1.5 2.1 1 0 0 1 1 1 1 PEP-utilising enzyme, N-terminal PEP-utilizers PF00391.23 ACT04825.1 - 1.7e-21 75.7 1.1 3.4e-21 74.7 1.1 1.5 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain DUF5082 PF16888.5 ACT04825.1 - 0.043 14.1 1.0 0.79 10.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Mannitol_dh_C PF08125.13 ACT04826.1 - 9e-54 182.5 0.1 1.3e-53 182.0 0.1 1.2 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 ACT04826.1 - 1.2e-20 74.2 0.1 2.6e-20 73.1 0.1 1.6 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain 3HCDH_N PF02737.18 ACT04826.1 - 0.0027 17.6 1.8 0.0056 16.6 0.4 2.1 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 ACT04826.1 - 0.0029 17.5 1.7 0.0095 15.8 0.9 2.1 2 0 0 2 2 2 1 NAD(P)H-binding UDPG_MGDP_dh_N PF03721.14 ACT04826.1 - 0.0056 16.3 0.3 0.0096 15.5 0.3 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 ACT04826.1 - 0.046 13.9 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ACT04826.1 - 0.67 10.6 3.8 8.7 7.0 3.8 2.4 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PTS_EIIA_2 PF00359.22 ACT04827.1 - 1.4e-31 109.4 0.0 1.5e-31 109.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 PRD PF00874.20 ACT04828.1 - 1.5e-25 89.3 0.0 1.1e-17 64.1 0.0 3.1 3 0 0 3 3 3 2 PRD domain HTH_11 PF08279.12 ACT04828.1 - 2.5e-19 69.0 0.6 1e-09 38.2 1.1 2.8 2 0 0 2 2 2 2 HTH domain PTS_EIIA_2 PF00359.22 ACT04828.1 - 1.5e-15 57.3 0.0 5.4e-15 55.6 0.0 1.9 2 0 0 2 2 2 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Mga PF05043.13 ACT04828.1 - 2.4e-10 40.8 1.5 0.00014 22.4 0.1 3.0 3 0 0 3 3 3 2 Mga helix-turn-helix domain PTS_IIB PF02302.17 ACT04828.1 - 1e-06 29.3 0.0 3.2e-06 27.7 0.0 1.9 1 0 0 1 1 1 1 PTS system, Lactose/Cellobiose specific IIB subunit HTH_24 PF13412.6 ACT04828.1 - 0.00019 20.9 0.3 0.00065 19.2 0.3 1.9 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 ACT04828.1 - 0.00041 20.2 2.0 0.0092 15.9 0.5 2.8 2 0 0 2 2 2 1 MarR family Sigma70_r4_2 PF08281.12 ACT04828.1 - 0.00078 19.1 0.7 0.011 15.3 0.1 2.9 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_Mga PF08280.11 ACT04828.1 - 0.0011 19.0 0.2 1.2 9.3 0.0 2.6 2 0 0 2 2 2 2 M protein trans-acting positive regulator (MGA) HTH domain HTH_Tnp_1_2 PF13022.6 ACT04828.1 - 0.0018 18.4 0.1 0.0046 17.1 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase HTH_IclR PF09339.10 ACT04828.1 - 0.0028 17.4 0.7 0.034 14.0 0.7 2.7 2 0 0 2 2 2 1 IclR helix-turn-helix domain Sigma70_r4 PF04545.16 ACT04828.1 - 0.015 14.8 0.5 0.015 14.8 0.5 3.6 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_23 PF13384.6 ACT04828.1 - 0.016 15.0 0.4 0.016 15.0 0.4 2.7 3 0 0 3 3 3 0 Homeodomain-like domain HTH_DeoR PF08220.12 ACT04828.1 - 0.029 14.1 5.5 0.44 10.3 0.9 3.1 3 0 0 3 3 3 0 DeoR-like helix-turn-helix domain HTH_38 PF13936.6 ACT04828.1 - 0.044 13.6 1.5 0.15 11.9 1.5 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_28 PF13518.6 ACT04828.1 - 0.065 13.4 1.3 0.2 11.8 0.2 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain UPF0122 PF04297.14 ACT04828.1 - 0.1 12.9 0.2 0.61 10.4 0.0 2.4 3 0 0 3 3 2 0 Putative helix-turn-helix protein, YlxM / p13 like HTH_20 PF12840.7 ACT04828.1 - 0.13 12.3 3.0 0.85 9.7 0.4 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_1 PF00126.27 ACT04828.1 - 0.15 12.0 1.5 5 7.2 0.7 3.0 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_AsnC-type PF13404.6 ACT04828.1 - 0.31 10.9 7.5 0.036 13.9 1.3 2.7 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain HTH_32 PF13565.6 ACT04828.1 - 2.5 8.8 4.8 1.7 9.3 1.0 2.9 2 0 0 2 2 2 0 Homeodomain-like domain PTS_EIIC PF02378.18 ACT04829.1 - 4.3e-19 68.7 31.9 6.2e-19 68.2 26.4 3.3 2 1 0 2 2 2 1 Phosphotransferase system, EIIC PTS_IIB PF02302.17 ACT04829.1 - 8.2e-14 52.1 0.3 8.2e-14 52.1 0.3 2.1 2 0 0 2 2 2 1 PTS system, Lactose/Cellobiose specific IIB subunit DUF2379 PF09543.10 ACT04829.1 - 0.085 13.0 1.2 0.14 12.3 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2379) DUF4953 PF16313.5 ACT04830.1 - 0.031 13.5 0.0 0.033 13.4 0.0 1.2 1 0 0 1 1 1 0 Met-zincin MFS_1 PF07690.16 ACT04831.1 - 8.5e-52 176.2 39.5 8.5e-52 176.2 39.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ACT04831.1 - 7.9e-06 25.0 24.5 8.6e-06 24.9 11.7 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.6 ACT04831.1 - 0.00023 19.9 30.2 0.0069 15.0 5.7 3.4 2 1 1 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 ACT04831.1 - 0.0009 18.2 7.5 0.0009 18.2 7.5 2.6 3 0 0 3 3 3 2 MFS_1 like family MFS_3 PF05977.13 ACT04831.1 - 0.09 11.1 22.5 0.14 10.6 9.8 2.4 2 1 0 2 2 2 0 Transmembrane secretion effector TetR_C_11 PF16859.5 ACT04832.1 - 4.1e-18 65.7 1.0 5.8e-18 65.2 0.2 1.6 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 ACT04832.1 - 1.9e-13 50.0 0.0 2.8e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family DUF648 PF04890.13 ACT04833.1 - 0.00086 19.1 0.8 0.0014 18.4 0.8 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF648) DUF4199 PF13858.6 ACT04833.1 - 0.066 13.6 9.9 0.76 10.2 2.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4199) Saf_2TM PF18303.1 ACT04833.1 - 0.091 12.3 0.8 1.2 8.7 0.2 2.2 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Sigma_reg_N PF13800.6 ACT04833.1 - 0.47 10.8 3.4 4.9 7.5 0.2 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF2644 PF10841.8 ACT04833.1 - 0.54 10.5 3.3 1.2 9.4 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2644) Promethin PF16015.5 ACT04833.1 - 9.5 6.2 10.5 15 5.6 9.8 1.7 1 1 0 1 1 1 0 Promethin Auxin_canalis PF05703.11 ACT04834.1 - 0.016 15.2 1.5 0.027 14.4 1.5 1.3 1 0 0 1 1 1 0 Auxin canalisation K1 PF02960.14 ACT04834.1 - 0.056 13.6 1.8 6.5 6.9 0.0 2.2 1 1 1 2 2 2 0 K1 glycoprotein TMEM215 PF15746.5 ACT04834.1 - 0.087 12.3 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 TMEM215 family DUF1435 PF07256.12 ACT04834.1 - 0.11 12.6 5.6 2.7 8.2 2.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1435) DUF5392 PF17370.2 ACT04834.1 - 0.15 12.2 0.1 0.26 11.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5392) Gemini_mov PF01708.16 ACT04834.1 - 0.18 11.6 1.3 0.35 10.6 1.3 1.5 1 0 0 1 1 1 0 Geminivirus putative movement protein PRRSV_2b PF07069.11 ACT04834.1 - 0.47 11.0 5.5 0.96 10.0 5.5 1.5 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b E1-E2_ATPase PF00122.20 ACT04834.1 - 9.1 5.8 11.8 0.57 9.7 5.8 2.1 2 1 1 3 3 3 0 E1-E2 ATPase Band_7_1 PF13421.6 ACT04835.1 - 4.9e-56 189.8 0.0 6.2e-56 189.4 0.0 1.1 1 0 0 1 1 1 1 SPFH domain-Band 7 family DZR PF12773.7 ACT04835.1 - 7.4e-25 86.7 41.3 3.5e-10 39.7 11.8 3.2 3 0 0 3 3 3 3 Double zinc ribbon zinc_ribbon_2 PF13240.6 ACT04835.1 - 1.6e-23 81.7 53.9 1.3e-06 27.9 2.4 5.5 5 0 0 5 5 5 5 zinc-ribbon domain zf-ribbon_3 PF13248.6 ACT04835.1 - 1.5e-13 49.6 49.7 0.0002 20.6 4.0 5.4 4 1 1 5 5 5 5 zinc-ribbon domain zinc_ribbon_15 PF17032.5 ACT04835.1 - 1e-12 48.6 31.2 0.02 15.7 0.7 5.3 5 0 0 5 5 5 5 zinc-ribbon family Band_7 PF01145.25 ACT04835.1 - 9.9e-06 25.7 0.0 1.8e-05 24.8 0.0 1.3 1 1 0 1 1 1 1 SPFH domain / Band 7 family UPF0547 PF10571.9 ACT04835.1 - 0.0011 18.9 50.9 0.0021 18.1 2.5 6.2 5 2 0 5 5 5 4 Uncharacterised protein family UPF0547 Cript PF10235.9 ACT04835.1 - 0.012 16.1 34.1 0.016 15.7 4.7 4.4 1 1 3 4 4 4 0 Microtubule-associated protein CRIPT zf-TRM13_CCCH PF11722.8 ACT04835.1 - 0.53 10.1 9.3 4.3 7.2 0.4 3.9 4 0 0 4 4 4 0 CCCH zinc finger in TRM13 protein MatE PF01554.18 ACT04836.1 - 2.2e-53 180.2 35.7 2.2e-28 99.0 12.0 2.7 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ACT04836.1 - 2.1e-06 27.9 17.4 2.1e-06 27.9 17.4 4.6 1 1 3 4 4 4 2 Polysaccharide biosynthesis C-terminal domain LapA_dom PF06305.11 ACT04836.1 - 0.015 15.1 2.0 0.015 15.1 2.0 3.4 5 0 0 5 5 5 0 Lipopolysaccharide assembly protein A domain DUF5534 PF17686.1 ACT04836.1 - 0.17 12.2 6.7 1.4 9.1 0.4 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5534) DUF5423 PF17461.2 ACT04836.1 - 1.9 7.2 6.1 1.2 8.0 0.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5423) CD225 PF04505.12 ACT04836.1 - 9.9 6.4 11.8 0.19 11.9 2.6 2.9 4 0 0 4 4 4 0 Interferon-induced transmembrane protein FAD_binding_4 PF01565.23 ACT04838.1 - 6.2e-31 107.0 0.5 1.3e-30 105.9 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 ACT04838.1 - 9.5e-21 73.6 2.1 1.9e-20 72.7 2.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like Exo_endo_phos PF03372.23 ACT04839.1 - 6.7e-07 29.1 0.0 2.6e-06 27.1 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GGDEF PF00990.21 ACT04840.1 - 1.7e-38 131.9 0.0 2.4e-38 131.4 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GAF_2 PF13185.6 ACT04840.1 - 1.5e-11 44.8 0.0 2.8e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 ACT04840.1 - 2.2e-07 31.3 0.0 4.9e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 ACT04840.1 - 3.6e-07 30.9 0.0 6.7e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 GAF domain DUF3502 PF12010.8 ACT04841.1 - 4e-36 124.5 0.1 1.8e-35 122.4 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3502) SBP_bac_8 PF13416.6 ACT04841.1 - 1.9e-12 47.6 0.1 3.3e-12 46.8 0.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 ACT04841.1 - 1.4e-08 35.1 5.3 6e-05 23.2 0.8 3.1 3 0 0 3 3 3 2 Bacterial extracellular solute-binding protein Response_reg PF00072.24 ACT04842.1 - 2.2e-19 69.7 0.0 3.3e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HTH_18 PF12833.7 ACT04842.1 - 6.3e-17 61.6 0.2 1.4e-16 60.5 0.2 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 ACT04842.1 - 2.8e-14 52.8 0.2 1.9e-08 34.2 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family His_kinase PF06580.13 ACT04843.1 - 1.3e-21 76.7 0.5 3.4e-21 75.3 0.5 1.7 1 0 0 1 1 1 1 Histidine kinase Complex1_LYR PF05347.15 ACT04843.1 - 0.011 15.8 0.0 0.049 13.7 0.0 2.2 1 0 0 1 1 1 0 Complex 1 protein (LYR family) HAMP PF00672.25 ACT04843.1 - 0.073 13.5 0.1 0.15 12.5 0.1 1.5 1 0 0 1 1 1 0 HAMP domain DUF3502 PF12010.8 ACT04844.1 - 4.9e-30 104.8 0.5 4.9e-30 104.8 0.5 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF3502) SBP_bac_1 PF01547.25 ACT04844.1 - 1.6e-11 44.7 14.3 1.6e-11 44.7 14.3 2.3 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein TrbI PF03743.14 ACT04844.1 - 0.02 14.8 1.6 0.54 10.1 1.1 2.6 2 0 0 2 2 2 0 Bacterial conjugation TrbI-like protein FATC PF02260.20 ACT04844.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 FATC domain LPAM_2 PF13627.6 ACT04844.1 - 0.55 10.2 1.8 0.89 9.5 1.8 1.3 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site BPD_transp_1 PF00528.22 ACT04845.1 - 6.5e-06 26.0 25.2 7.1e-05 22.6 25.2 2.5 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 ACT04846.1 - 8.2e-12 45.2 15.5 8.2e-12 45.2 15.5 2.7 1 1 2 3 3 3 1 Binding-protein-dependent transport system inner membrane component SPOUT_MTase PF02590.17 ACT04847.1 - 3.1e-56 189.6 0.0 3.4e-56 189.5 0.0 1.0 1 0 0 1 1 1 1 Predicted SPOUT methyltransferase Ank_4 PF13637.6 ACT04848.1 - 5.5e-26 90.6 0.0 4.3e-06 27.2 0.0 4.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 ACT04848.1 - 4.6e-24 84.8 0.5 1.3e-10 41.7 0.2 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ACT04848.1 - 1.5e-18 66.6 1.0 1.4e-07 31.6 0.1 4.4 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 ACT04848.1 - 9.7e-17 60.6 3.2 0.0016 18.8 0.1 6.1 7 0 0 7 7 7 4 Ankyrin repeat Ank_3 PF13606.6 ACT04848.1 - 6.9e-16 56.8 0.0 0.0086 16.5 0.1 5.8 5 0 0 5 5 5 4 Ankyrin repeat DUF5547 PF17701.1 ACT04848.1 - 0.11 12.3 0.1 0.3 11.0 0.1 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5547) DUF3107 PF11305.8 ACT04848.1 - 0.15 12.4 1.1 2.1 8.6 0.2 2.9 2 1 2 4 4 4 0 Protein of unknown function (DUF3107) YyzF PF14116.6 ACT04849.1 - 4.1e-20 71.5 1.3 4.7e-20 71.4 1.3 1.0 1 0 0 1 1 1 1 YyzF-like protein UPF0060 PF02694.15 ACT04850.1 - 1.8e-46 156.8 11.9 2e-46 156.6 11.9 1.0 1 0 0 1 1 1 1 Uncharacterised BCR, YnfA/UPF0060 family EamA PF00892.20 ACT04850.1 - 0.00059 20.0 9.1 0.0011 19.2 9.1 1.5 1 1 0 1 1 1 1 EamA-like transporter family DUF3054 PF11255.8 ACT04850.1 - 0.26 11.8 5.9 0.31 11.6 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3054) DUF5381 PF17353.2 ACT04850.1 - 0.38 10.5 4.2 0.17 11.6 2.1 1.4 1 1 1 2 2 2 0 Family of unknown function (DUF5381) Multi_Drug_Res PF00893.19 ACT04850.1 - 0.4 11.4 7.4 0.59 10.8 7.4 1.3 1 0 0 1 1 1 0 Small Multidrug Resistance protein MFS_1 PF07690.16 ACT04850.1 - 0.47 9.3 13.2 0.07 12.0 6.5 1.9 1 1 1 2 2 2 0 Major Facilitator Superfamily DUF2964 PF11177.8 ACT04850.1 - 8.2 6.7 8.9 1.9 8.7 0.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2964) DUF998 PF06197.13 ACT04850.1 - 9.9 5.7 16.0 54 3.3 3.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF998) DUF4097 PF13349.6 ACT04851.1 - 2.3e-28 99.2 15.8 6.7e-28 97.7 15.8 1.6 1 1 0 1 1 1 1 Putative adhesin Trypsin_2 PF13365.6 ACT04852.1 - 3e-25 89.9 0.3 5.1e-25 89.1 0.3 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 ACT04852.1 - 1e-13 51.4 0.2 4.2e-13 49.4 0.0 2.2 2 0 0 2 2 2 1 PDZ domain Trypsin PF00089.26 ACT04852.1 - 2.3e-11 43.9 0.0 4.6e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 ACT04852.1 - 0.00029 20.6 0.0 0.0012 18.6 0.0 2.1 2 0 0 2 2 2 1 PDZ domain DUF150_C PF17384.2 ACT04852.1 - 0.036 14.2 0.3 1.8 8.8 0.1 2.5 2 0 0 2 2 2 0 RimP C-terminal SH3 domain Peptidase_S29 PF02907.15 ACT04852.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease DUF31 PF01732.16 ACT04852.1 - 0.42 10.1 4.4 5.9 6.3 0.2 2.9 2 1 1 3 3 3 0 Putative peptidase (DUF31) HTH_52 PF18576.1 ACT04853.1 - 0.0089 16.2 0.1 0.014 15.6 0.1 1.4 1 1 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 ACT04853.1 - 0.02 14.8 0.1 0.03 14.3 0.1 1.3 1 0 0 1 1 1 0 MarR family Penicillinase_R PF03965.16 ACT04853.1 - 0.02 15.2 0.2 0.034 14.5 0.2 1.3 1 1 0 1 1 1 0 Penicillinase repressor Lebercilin PF15619.6 ACT04853.1 - 0.026 14.2 0.7 0.03 14.0 0.7 1.0 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF1803 PF08820.10 ACT04853.1 - 0.035 14.1 0.0 0.28 11.2 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1803) SHOCT PF09851.9 ACT04853.1 - 0.061 13.1 0.2 0.061 13.1 0.2 1.9 2 0 0 2 2 2 0 Short C-terminal domain FeoC PF09012.10 ACT04853.1 - 0.07 13.2 0.0 0.081 13.0 0.0 1.3 1 0 0 1 1 1 0 FeoC like transcriptional regulator NHase_beta PF02211.15 ACT04853.1 - 0.1 12.6 0.0 0.1 12.6 0.0 1.1 1 0 0 1 1 1 0 Nitrile hydratase beta subunit MarR_2 PF12802.7 ACT04853.1 - 0.13 12.1 0.1 0.18 11.7 0.1 1.3 1 1 0 1 1 1 0 MarR family NHase_alpha PF02979.16 ACT04853.1 - 0.14 11.4 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Nitrile hydratase, alpha chain Lactamase_B_2 PF12706.7 ACT04854.1 - 3.3e-22 79.0 0.0 5e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ACT04854.1 - 4.6e-16 59.4 0.1 5.7e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily YycI PF09648.10 ACT04855.1 - 1.5e-13 50.9 0.0 4.2e-13 49.4 0.0 1.6 1 1 0 1 1 1 1 YycH protein Glyco_hydro_92N PF17678.1 ACT04855.1 - 0.065 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 92 N-terminal domain YycH PF07435.11 ACT04856.1 - 1.8e-36 126.1 0.0 2.2e-36 125.8 0.0 1.0 1 0 0 1 1 1 1 YycH protein HATPase_c PF02518.26 ACT04857.1 - 1.3e-30 106.2 0.2 4.5e-30 104.4 0.1 2.0 2 0 0 2 2 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ACT04857.1 - 1.2e-19 70.1 2.4 9.9e-19 67.1 0.9 2.8 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 ACT04857.1 - 8.9e-16 58.0 0.2 1.7e-14 53.9 0.1 2.5 2 0 0 2 2 2 1 HAMP domain PAS_4 PF08448.10 ACT04857.1 - 1.1e-06 28.8 0.1 7.8e-06 26.1 0.1 2.5 2 1 0 2 2 2 1 PAS fold HATPase_c_3 PF13589.6 ACT04857.1 - 1.6e-06 28.0 0.1 3.2e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_7 PF12860.7 ACT04857.1 - 1.5e-05 25.2 0.2 7.3e-05 22.9 0.2 2.2 1 1 0 1 1 1 1 PAS fold PAS PF00989.25 ACT04857.1 - 6.4e-05 22.9 0.1 0.00021 21.3 0.1 2.0 1 1 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ACT04857.1 - 0.00025 21.2 0.1 0.0011 19.1 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS_8 PF13188.7 ACT04857.1 - 0.00054 19.9 0.0 0.0015 18.5 0.0 1.8 1 0 0 1 1 1 1 PAS domain HATPase_c_5 PF14501.6 ACT04857.1 - 0.0011 18.9 0.0 0.0029 17.5 0.0 1.8 1 0 0 1 1 1 1 GHKL domain PAS_10 PF13596.6 ACT04857.1 - 0.0032 18.0 0.0 0.053 14.1 0.0 2.7 2 0 0 2 2 2 1 PAS domain dCache_1 PF02743.18 ACT04857.1 - 0.0045 16.8 5.3 0.014 15.2 2.5 2.9 3 1 0 3 3 3 1 Cache domain dCache_3 PF14827.6 ACT04857.1 - 0.009 15.7 1.7 0.019 14.6 0.3 2.2 3 0 0 3 3 3 1 Double sensory domain of two-component sensor kinase AI-2E_transport PF01594.16 ACT04857.1 - 0.12 11.6 6.9 0.16 11.1 1.0 2.3 2 0 0 2 2 2 0 AI-2E family transporter Sensor_TM1 PF13755.6 ACT04857.1 - 0.68 9.7 3.8 0.46 10.3 1.2 2.0 2 0 0 2 2 2 0 Sensor N-terminal transmembrane domain Response_reg PF00072.24 ACT04858.1 - 9.8e-27 93.3 0.3 1.8e-26 92.5 0.3 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 ACT04858.1 - 1.1e-26 92.7 0.1 2.2e-26 91.8 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Peptidase_M23 PF01551.22 ACT04859.1 - 5.7e-31 106.6 4.6 8.1e-29 99.7 3.3 3.1 2 0 0 2 2 2 2 Peptidase family M23 G5 PF07501.12 ACT04859.1 - 8.7e-17 61.3 6.9 8.7e-17 61.3 6.9 2.7 3 0 0 3 3 3 1 G5 domain LysM PF01476.20 ACT04859.1 - 1.9e-06 27.8 0.6 8e-05 22.6 0.1 3.3 3 0 0 3 3 3 1 LysM domain Biotin_lipoyl_2 PF13533.6 ACT04859.1 - 0.038 13.8 0.5 0.3 11.0 0.1 2.7 2 0 0 2 2 2 0 Biotin-lipoyl like DUF3535 PF12054.8 ACT04860.1 - 0.0062 15.8 0.3 0.72 9.0 0.1 2.1 1 1 0 2 2 2 2 Domain of unknown function (DUF3535) Adenylsucc_synt PF00709.21 ACT04861.1 - 9.7e-183 607.8 0.2 1.1e-182 607.6 0.2 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DnaB_C PF03796.15 ACT04862.1 - 5e-118 393.0 1.0 7.8e-118 392.4 1.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain DnaB PF00772.21 ACT04862.1 - 6.1e-35 119.4 0.2 1.7e-34 118.0 0.2 1.8 1 0 0 1 1 1 1 DnaB-like helicase N terminal domain AAA_25 PF13481.6 ACT04862.1 - 1.1e-10 41.4 0.1 1.9e-10 40.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ACT04862.1 - 8.8e-05 22.0 0.2 0.00072 19.0 0.2 2.4 1 1 0 1 1 1 1 KaiC AAA PF00004.29 ACT04862.1 - 0.0002 21.8 0.0 0.0009 19.7 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Ribosomal_L9_C PF03948.14 ACT04863.1 - 6e-29 100.4 5.0 9.1e-29 99.8 5.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L9, C-terminal domain Ribosomal_L9_N PF01281.19 ACT04863.1 - 1.3e-21 75.8 1.8 1.4e-21 75.7 0.3 1.9 2 0 0 2 2 2 1 Ribosomal protein L9, N-terminal domain DHH PF01368.20 ACT04864.1 - 9.8e-23 80.3 0.1 2.8e-22 78.9 0.1 1.8 1 0 0 1 1 1 1 DHH family DHHA1 PF02272.19 ACT04864.1 - 5.6e-11 43.0 2.1 9.7e-11 42.2 0.6 2.2 2 0 0 2 2 2 1 DHHA1 domain PAS_9 PF13426.7 ACT04864.1 - 0.0061 16.8 0.0 0.027 14.7 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 ACT04864.1 - 0.057 13.7 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 PAS fold DUF2862 PF11061.8 ACT04864.1 - 0.16 11.8 0.2 1.6 8.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2862) DUF2232 PF09991.9 ACT04865.1 - 3.5e-35 121.6 31.1 4.8e-35 121.2 31.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) CENP-F_C_Rb_bdg PF10490.9 ACT04865.1 - 0.0088 15.5 1.2 0.065 12.7 0.1 2.3 2 0 0 2 2 2 1 Rb-binding domain of kinetochore protein Cenp-F/LEK1 Amidohydro_3 PF07969.11 ACT04866.1 - 4.1e-16 59.5 0.4 8.9e-13 48.5 0.0 2.9 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 ACT04866.1 - 7.6e-11 41.9 0.0 2.2e-10 40.4 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase family PC4 PF02229.16 ACT04866.1 - 0.085 12.5 0.0 1 9.1 0.0 2.2 2 0 0 2 2 2 0 Transcriptional Coactivator p15 (PC4) CBS PF00571.28 ACT04867.1 - 2.6e-19 69.4 0.0 1.8e-11 44.3 0.0 2.1 2 0 0 2 2 2 2 CBS domain PcrB PF01884.17 ACT04867.1 - 0.11 12.0 0.0 0.33 10.4 0.0 1.6 2 0 0 2 2 2 0 PcrB family DUF3659 PF12396.8 ACT04867.1 - 0.13 12.2 0.1 11 6.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) DUF4870 PF09685.10 ACT04868.1 - 1.5e-05 25.1 8.1 2e-05 24.7 8.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4870) TIC20 PF16166.5 ACT04868.1 - 0.00025 20.9 2.2 0.00033 20.5 2.2 1.2 1 0 0 1 1 1 1 Chloroplast import apparatus Tic20-like EI24 PF07264.11 ACT04868.1 - 0.43 10.8 11.3 0.87 9.8 11.3 1.5 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF1836 PF08876.11 ACT04869.1 - 4.8e-11 42.6 0.0 9.6e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1836) NRBF2_MIT PF17169.4 ACT04869.1 - 0.022 15.0 0.1 0.039 14.2 0.1 1.4 1 0 0 1 1 1 0 MIT domain of nuclear receptor-binding factor 2 DUF21 PF01595.20 ACT04870.1 - 2.6e-46 157.5 3.8 4.3e-46 156.8 3.8 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CorC_HlyC PF03471.17 ACT04870.1 - 1.9e-18 66.2 0.2 4e-18 65.2 0.2 1.6 1 0 0 1 1 1 1 Transporter associated domain CBS PF00571.28 ACT04870.1 - 4.3e-11 43.1 0.2 9.7e-05 22.7 0.1 2.5 2 0 0 2 2 2 2 CBS domain Na_H_Exchanger PF00999.21 ACT04871.1 - 2.2e-80 270.3 40.9 2.5e-80 270.1 40.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Pyr_redox_2 PF07992.14 ACT04872.1 - 1.1e-43 149.6 0.8 1.3e-43 149.4 0.8 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ACT04872.1 - 1.8e-05 25.2 2.0 0.002 18.7 0.9 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ACT04872.1 - 0.00074 18.9 0.6 0.028 13.7 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ACT04872.1 - 0.0068 15.2 0.2 4.6 5.8 0.0 3.2 3 0 0 3 3 3 2 HI0933-like protein Tricorn_PDZ PF14685.6 ACT04872.1 - 0.019 14.9 0.0 0.066 13.2 0.0 1.9 1 0 0 1 1 1 0 Tricorn protease PDZ domain Trp_halogenase PF04820.14 ACT04872.1 - 0.18 10.7 0.0 0.33 9.7 0.0 1.4 1 0 0 1 1 1 0 Tryptophan halogenase DAO PF01266.24 ACT04872.1 - 1.6 8.2 5.5 14 5.2 0.3 3.0 2 1 0 3 3 3 0 FAD dependent oxidoreductase DUF1641 PF07849.11 ACT04873.1 - 2.1e-08 33.9 0.1 1.4e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1641) CHAD PF05235.14 ACT04873.1 - 0.11 12.5 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 CHAD domain Ribosomal_S18 PF01084.20 ACT04874.1 - 7.2e-27 93.4 0.6 9.2e-27 93.0 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S18 SSB PF00436.25 ACT04875.1 - 1.3e-36 124.8 0.1 1.6e-36 124.5 0.1 1.1 1 0 0 1 1 1 1 Single-strand binding protein family GRP PF07172.11 ACT04875.1 - 0.2 12.4 15.2 0.31 11.7 15.2 1.3 1 0 0 1 1 1 0 Glycine rich protein family Ribosomal_S6 PF01250.17 ACT04876.1 - 1.2e-29 102.4 1.2 1.4e-29 102.2 1.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S6 NAS PF03059.16 ACT04876.1 - 0.033 13.5 0.3 0.044 13.1 0.3 1.3 1 1 0 1 1 1 0 Nicotianamine synthase protein YjzC PF14168.6 ACT04877.1 - 9.8e-26 89.9 1.0 1.1e-25 89.7 1.0 1.0 1 0 0 1 1 1 1 YjzC-like protein Pyr_redox_2 PF07992.14 ACT04878.1 - 1.3e-13 50.9 0.3 0.00062 19.1 0.1 3.3 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ACT04878.1 - 2.5e-07 30.2 2.3 0.00011 21.4 0.8 3.0 2 1 0 2 2 2 2 Glucose inhibited division protein A HI0933_like PF03486.14 ACT04878.1 - 2.8e-07 29.6 0.9 7.1e-06 25.0 0.9 2.1 1 1 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 ACT04878.1 - 1.3e-06 27.9 0.0 0.041 13.1 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ACT04878.1 - 1.4e-06 27.7 1.1 2.5e-05 23.5 1.1 2.3 1 1 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 ACT04878.1 - 5.4e-06 26.5 0.3 0.0077 16.2 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 ACT04878.1 - 1.8e-05 24.5 0.7 0.00021 21.0 0.1 2.1 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ACT04878.1 - 4.4e-05 23.6 0.1 0.00035 20.7 0.1 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ACT04878.1 - 4.8e-05 22.6 0.1 0.053 12.6 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_oxidored PF12831.7 ACT04878.1 - 0.00038 19.9 0.6 0.0028 17.0 0.6 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ACT04878.1 - 0.00052 19.4 0.0 0.0012 18.2 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ACT04878.1 - 0.0012 19.4 0.3 0.06 13.9 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ACT04878.1 - 0.0023 17.2 0.2 0.005 16.1 0.1 1.6 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 ACT04878.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 ACT04878.1 - 0.035 13.7 0.1 0.083 12.5 0.1 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 ACT04878.1 - 0.2 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF951 PF06107.11 ACT04879.1 - 4.5e-30 103.3 3.8 5.4e-30 103.1 3.8 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF951) MS_channel PF00924.18 ACT04880.1 - 1.4e-42 145.6 3.4 1.8e-42 145.2 3.4 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel DUF3343 PF11823.8 ACT04881.1 - 4e-19 67.8 0.1 4.5e-19 67.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3343) DUF1256 PF06866.11 ACT04882.1 - 5.8e-66 220.9 0.0 6.9e-66 220.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1256) DUF4446 PF14584.6 ACT04883.1 - 4.1e-45 153.4 1.2 4.5e-45 153.3 1.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) SlyX PF04102.12 ACT04883.1 - 0.07 13.7 3.9 0.075 13.7 2.9 1.5 2 0 0 2 2 2 0 SlyX ECSCR PF15820.5 ACT04883.1 - 0.077 12.8 0.2 0.12 12.2 0.2 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Aminotran_5 PF00266.19 ACT04884.1 - 1.3e-90 304.1 0.3 1.4e-90 303.9 0.3 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ACT04884.1 - 3e-13 49.1 0.0 4.3e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ACT04884.1 - 1.9e-11 43.9 0.3 2.7e-11 43.4 0.3 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 ACT04884.1 - 2.8e-09 36.7 0.1 4.2e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 ACT04884.1 - 3e-09 36.5 0.0 9.9e-09 34.8 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II Pyridoxal_deC PF00282.19 ACT04884.1 - 0.048 12.4 0.0 0.071 11.8 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain ParBc PF02195.18 ACT04885.1 - 2.4e-28 98.3 0.1 6.6e-28 96.8 0.1 1.8 1 0 0 1 1 1 1 ParB-like nuclease domain HTH_ParB PF17762.1 ACT04885.1 - 6.5e-17 61.1 1.9 1.7e-16 59.7 0.1 2.6 3 0 0 3 3 3 1 HTH domain found in ParB protein HTH_3 PF01381.22 ACT04885.1 - 0.00077 19.5 0.1 0.01 15.9 0.0 2.8 3 0 0 3 3 3 1 Helix-turn-helix KorB PF08535.10 ACT04885.1 - 0.0091 16.0 0.1 0.091 12.8 0.0 2.4 2 1 0 2 2 2 1 KorB domain UPF0175 PF03683.13 ACT04885.1 - 0.014 15.1 0.0 0.054 13.2 0.0 2.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0175) Syntaxin-6_N PF09177.11 ACT04885.1 - 0.017 15.6 1.3 0.051 14.1 0.7 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal HTH_19 PF12844.7 ACT04885.1 - 0.035 14.1 0.3 0.26 11.3 0.0 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain DUF4974 PF16344.5 ACT04885.1 - 0.4 10.7 2.1 4.7 7.3 0.4 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4974) AAA_31 PF13614.6 ACT04886.1 - 1.4e-71 240.1 2.5 8e-71 237.6 1.4 1.9 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 ACT04886.1 - 1.9e-28 99.1 0.1 2.7e-28 98.6 0.1 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 ACT04886.1 - 2.1e-13 50.4 1.7 5.7e-13 48.9 1.7 1.6 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 ACT04886.1 - 6.9e-13 48.5 0.5 2.7e-06 26.9 0.2 2.3 2 1 0 2 2 2 2 ATPase MipZ ParA PF10609.9 ACT04886.1 - 7.8e-13 48.4 1.2 2.3e-12 46.9 1.2 1.8 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 ACT04886.1 - 2.6e-12 46.7 0.0 4.1e-12 46.1 0.0 1.4 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ArsA_ATPase PF02374.15 ACT04886.1 - 2.2e-08 33.7 1.6 1.3e-07 31.2 1.7 2.2 1 1 0 1 1 1 1 Anion-transporting ATPase SRP54 PF00448.22 ACT04886.1 - 0.00047 19.8 0.6 0.97 9.0 0.1 2.4 2 1 0 2 2 2 2 SRP54-type protein, GTPase domain VirC1 PF07015.11 ACT04886.1 - 0.00087 18.7 1.4 0.0025 17.1 0.1 2.1 2 1 1 3 3 3 1 VirC1 protein MeaB PF03308.16 ACT04886.1 - 0.02 13.9 0.2 0.039 12.9 0.2 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 ACT04886.1 - 0.039 13.7 0.1 2 8.2 0.1 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 ACT04886.1 - 0.058 13.2 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ParBc PF02195.18 ACT04887.1 - 2e-26 92.1 0.2 2e-26 92.1 0.2 1.9 2 0 0 2 2 2 1 ParB-like nuclease domain HTH_ParB PF17762.1 ACT04887.1 - 8.7e-19 67.1 3.4 8.7e-19 67.1 3.4 2.1 2 0 0 2 2 1 1 HTH domain found in ParB protein HTH_50 PF18024.1 ACT04887.1 - 0.00012 21.6 0.0 0.00025 20.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain KorB PF08535.10 ACT04887.1 - 0.00039 20.4 0.5 0.0016 18.4 0.1 2.2 2 1 0 2 2 2 1 KorB domain HTH_3 PF01381.22 ACT04887.1 - 0.0018 18.3 0.3 0.0044 17.0 0.3 1.7 1 0 0 1 1 1 1 Helix-turn-helix TrmB PF01978.19 ACT04887.1 - 0.0032 17.3 0.2 0.0067 16.3 0.2 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_37 PF13744.6 ACT04887.1 - 0.0068 16.3 0.7 0.34 10.9 0.4 3.2 3 1 1 4 4 4 1 Helix-turn-helix domain HTH_38 PF13936.6 ACT04887.1 - 0.012 15.4 0.0 0.029 14.2 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_11 PF08279.12 ACT04887.1 - 0.016 15.2 0.6 0.2 11.6 0.2 2.6 2 0 0 2 2 2 0 HTH domain UBA_6 PF18039.1 ACT04887.1 - 0.042 13.8 0.5 8.9 6.3 0.1 3.3 3 0 0 3 3 3 0 UBA-like domain DUF2203 PF09969.9 ACT04887.1 - 0.062 14.0 1.1 0.062 14.0 1.1 2.6 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Sigma70_r4 PF04545.16 ACT04887.1 - 0.071 12.6 0.0 0.071 12.6 0.0 2.5 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_Crp_2 PF13545.6 ACT04887.1 - 0.097 12.7 1.5 0.55 10.2 0.1 2.5 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain DUF4162 PF13732.6 ACT04887.1 - 0.26 12.1 2.2 0.49 11.1 1.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4162) Mut7-C PF01927.16 ACT04887.1 - 0.3 11.2 1.7 0.45 10.6 1.1 1.6 1 1 1 2 2 2 0 Mut7-C RNAse domain GidB PF02527.15 ACT04888.1 - 4.5e-55 185.8 0.0 6.7e-55 185.3 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_31 PF13847.6 ACT04888.1 - 6.6e-07 29.2 0.0 1.1e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ACT04888.1 - 7.4e-07 29.8 0.0 1.2e-05 26.0 0.0 2.2 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ACT04888.1 - 1.4e-06 28.8 0.0 2.5e-05 24.8 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 ACT04888.1 - 8.7e-05 22.1 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 ACT04888.1 - 0.011 16.5 0.0 0.024 15.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 ACT04888.1 - 0.017 14.6 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase GIDA PF01134.22 ACT04889.1 - 4.4e-173 575.9 0.0 5.8e-173 575.5 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 ACT04889.1 - 3.9e-77 259.2 0.3 6.4e-77 258.5 0.3 1.3 1 0 0 1 1 1 1 GidA associated domain FAD_binding_2 PF00890.24 ACT04889.1 - 6.3e-06 25.5 7.1 0.013 14.6 0.1 2.9 3 0 0 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 ACT04889.1 - 1.5e-05 24.5 0.1 3.9e-05 23.2 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ACT04889.1 - 5.2e-05 22.6 0.2 0.00013 21.3 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ACT04889.1 - 0.0023 17.6 0.5 0.1 12.2 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ACT04889.1 - 0.0097 15.2 0.7 0.81 8.9 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ACT04889.1 - 0.013 14.8 0.1 0.039 13.3 0.1 1.7 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 ACT04889.1 - 0.061 12.0 2.0 0.2 10.3 0.4 2.3 2 0 0 2 2 2 0 HI0933-like protein MnmE_helical PF12631.7 ACT04890.1 - 5.4e-57 193.3 6.2 7e-57 192.9 6.2 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 ACT04890.1 - 2.2e-40 137.6 1.0 3.3e-40 137.0 0.2 1.8 2 0 0 2 2 2 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 ACT04890.1 - 3.3e-26 91.6 0.1 7.6e-26 90.4 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ACT04890.1 - 1.3e-09 37.7 0.7 2.6e-09 36.8 0.7 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ACT04890.1 - 1.8e-07 31.4 0.2 0.023 14.7 0.0 2.5 1 1 1 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 ACT04890.1 - 1.2e-06 28.5 0.4 0.0051 16.7 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase Ras PF00071.22 ACT04890.1 - 0.00017 21.2 0.0 0.00038 20.1 0.0 1.6 1 1 0 1 1 1 1 Ras family ABC_tran PF00005.27 ACT04890.1 - 0.0047 17.4 0.6 0.015 15.8 0.6 1.9 1 1 0 1 1 1 1 ABC transporter MMR_HSR1_Xtn PF16897.5 ACT04890.1 - 0.0063 16.5 0.3 0.025 14.6 0.2 2.1 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain Roc PF08477.13 ACT04890.1 - 0.0095 16.1 0.0 0.023 14.9 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ACT04890.1 - 0.011 15.2 1.5 0.13 11.7 1.5 2.2 1 1 0 1 1 1 0 ADP-ribosylation factor family AAA_15 PF13175.6 ACT04890.1 - 0.045 13.5 0.2 0.071 12.8 0.2 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_16 PF13191.6 ACT04890.1 - 0.085 13.2 0.1 0.25 11.7 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain Jag_N PF14804.6 ACT04891.1 - 3.1e-18 65.8 0.3 5.2e-18 65.1 0.3 1.4 1 0 0 1 1 1 1 Jag N-terminus R3H PF01424.22 ACT04891.1 - 1e-16 60.6 0.6 2.1e-16 59.6 0.6 1.5 1 0 0 1 1 1 1 R3H domain KH_4 PF13083.6 ACT04891.1 - 1.2e-14 54.0 0.7 3e-14 52.7 0.1 2.0 2 0 0 2 2 2 1 KH domain Vps54_N PF10475.9 ACT04891.1 - 0.041 13.2 0.0 2.1 7.5 0.0 2.0 1 1 1 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex 60KD_IMP PF02096.20 ACT04892.1 - 3.8e-58 196.1 13.9 5.1e-58 195.6 13.9 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein Vpu PF00558.19 ACT04892.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Vpu protein DUF334 PF03904.13 ACT04892.1 - 1.6 8.2 6.1 0.49 9.9 0.5 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF334) Ribonuclease_P PF00825.18 ACT04893.1 - 6.5e-31 106.7 2.1 7.3e-31 106.5 2.1 1.0 1 0 0 1 1 1 1 Ribonuclease P RNase_E_G PF10150.9 ACT04893.1 - 0.0011 18.4 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease E/G family Ribosomal_L34 PF00468.17 ACT04894.1 - 1.5e-20 72.8 7.5 1.6e-20 72.8 7.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L34 # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Paenibacillus_sp._JDR-2-ASM2358v1/GCA_000023585.1_ASM2358v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Paenibacillus_sp._JDR-2-ASM2358v1/GCA_000023585.1_ASM2358v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Paenibacillus_sp._JDR-2-ASM2358v1/GCA_000023585.1_ASM2358v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Paenibacillus_sp._JDR-2-ASM2358v1/GCA_000023585.1_ASM2358v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 03:54:45 2019 # [ok]