# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Bac_DnaA PF00308.18 CDK97216.1 - 1.1e-90 303.4 1.7 1.2e-90 303.1 0.4 1.8 2 0 0 2 2 2 1 Bacterial dnaA protein Bac_DnaA_C PF08299.11 CDK97216.1 - 3.5e-33 113.4 0.7 8e-32 109.1 0.4 2.4 2 0 0 2 2 2 1 Bacterial dnaA protein helix-turn-helix DnaA_N PF11638.8 CDK97216.1 - 9.4e-20 70.1 0.0 2e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 DnaA N-terminal domain IstB_IS21 PF01695.17 CDK97216.1 - 8.4e-10 38.7 0.0 1.5e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AFG1_ATPase PF03969.16 CDK97216.1 - 3.2e-06 26.3 1.2 0.018 13.9 0.2 2.5 1 1 1 2 2 2 2 AFG1-like ATPase AAA PF00004.29 CDK97216.1 - 6.6e-06 26.6 0.0 1.9e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CDK97216.1 - 0.00056 19.9 0.0 0.0012 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CDK97216.1 - 0.0013 18.7 0.0 0.003 17.5 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CDK97216.1 - 0.0024 18.2 3.2 1.7 8.9 0.1 3.4 2 2 2 4 4 4 2 AAA domain AAA_16 PF13191.6 CDK97216.1 - 0.0028 18.1 0.2 0.0094 16.3 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 CDK97216.1 - 0.0065 16.8 0.1 0.06 13.7 0.0 2.3 1 1 1 2 2 2 1 AAA domain NACHT PF05729.12 CDK97216.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.7 1 0 0 1 1 1 0 NACHT domain RuvB_N PF05496.12 CDK97216.1 - 0.032 14.0 0.1 0.13 12.0 0.1 2.0 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CDK97216.1 - 0.047 14.1 0.0 0.11 12.9 0.0 1.6 1 1 0 1 1 1 0 RNA helicase TsaE PF02367.17 CDK97216.1 - 0.052 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DNA_pol3_beta PF00712.19 CDK97217.1 - 8.8e-40 135.6 0.0 2.5e-33 114.8 0.0 3.1 3 0 0 3 3 3 3 DNA polymerase III beta subunit, N-terminal domain DNA_pol3_beta_2 PF02767.16 CDK97217.1 - 1.2e-37 128.7 0.0 6.9e-32 110.1 0.0 2.7 3 0 0 3 3 3 2 DNA polymerase III beta subunit, central domain DNA_pol3_beta_3 PF02768.15 CDK97217.1 - 1.2e-35 121.9 0.1 1.7e-33 115.0 0.0 2.4 2 0 0 2 2 2 2 DNA polymerase III beta subunit, C-terminal domain DUF4168 PF13767.6 CDK97217.1 - 0.13 13.4 0.1 0.32 12.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4168) SMC_N PF02463.19 CDK97218.1 - 1.1e-15 57.7 0.0 1.8e-15 57.0 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDK97218.1 - 3.9e-11 43.3 0.1 2.3e-06 27.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDK97218.1 - 0.00084 19.9 0.0 0.0013 19.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CDK97218.1 - 0.0013 18.5 0.0 0.0045 16.7 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 CDK97218.1 - 0.0055 17.0 0.1 0.012 15.9 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDK97218.1 - 0.013 15.3 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CDK97218.1 - 0.014 15.8 0.2 0.014 15.8 0.2 2.3 2 1 0 2 2 2 0 AAA ATPase domain SbcCD_C PF13558.6 CDK97218.1 - 0.026 14.8 0.0 0.071 13.4 0.0 1.7 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 CDK97218.1 - 0.033 14.7 0.0 0.36 11.4 0.0 2.2 2 0 0 2 2 2 0 ABC transporter MukB PF04310.12 CDK97218.1 - 0.046 13.5 0.0 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 MukB N-terminal DNA_gyraseB PF00204.25 CDK97219.1 - 1.3e-60 203.8 0.0 2.2e-60 203.1 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase B DNA_gyraseB_C PF00986.21 CDK97219.1 - 2e-29 101.6 0.0 6.2e-29 100.0 0.0 1.9 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 CDK97219.1 - 2.5e-21 76.3 0.1 4.8e-21 75.4 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CDK97219.1 - 4e-17 62.3 0.0 1.1e-16 60.9 0.0 1.8 2 0 0 2 2 2 1 Toprim domain GyrB_insert PF18053.1 CDK97219.1 - 1.8e-06 27.9 0.0 3.4e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase B subunit insert domain HATPase_c_3 PF13589.6 CDK97219.1 - 0.00028 20.7 0.1 0.00071 19.4 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim_4 PF13662.6 CDK97219.1 - 0.14 12.6 0.3 0.76 10.3 0.0 2.4 2 0 0 2 2 2 0 Toprim domain HK97-gp10_like PF04883.12 CDK97219.1 - 0.17 12.9 1.5 0.49 11.4 1.0 2.1 2 0 0 2 2 2 0 Bacteriophage HK97-gp10, putative tail-component Ferric_reduct PF01794.19 CDK97220.1 - 5.6e-18 65.3 4.2 5.6e-18 65.3 4.2 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 CDK97220.1 - 1.3e-05 25.5 0.0 2.2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_8 PF08022.12 CDK97220.1 - 4.8e-05 23.4 0.0 0.00011 22.2 0.0 1.6 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 CDK97220.1 - 0.0024 18.5 0.0 0.014 16.0 0.0 2.0 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CDK97220.1 - 0.12 12.5 0.0 0.37 10.9 0.0 1.7 2 0 0 2 2 2 0 Ferric reductase NAD binding domain PhoLip_ATPase_N PF16209.5 CDK97222.1 - 0.065 12.9 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Phospholipid-translocating ATPase N-terminal GTP_EFTU PF00009.27 CDK97223.1 - 9.7e-63 211.2 0.0 1.6e-62 210.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDK97223.1 - 2.2e-39 134.0 0.1 4.3e-39 133.0 0.1 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 CDK97223.1 - 7.1e-31 106.1 0.0 2.2e-30 104.5 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CDK97223.1 - 1.4e-27 95.5 0.1 3.7e-27 94.2 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDK97223.1 - 1.9e-13 50.6 0.1 8.9e-13 48.4 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CDK97223.1 - 0.00064 19.6 0.0 0.0015 18.4 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CDK97223.1 - 0.0017 18.5 0.1 0.0041 17.2 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CDK97223.1 - 0.0023 17.3 0.1 0.0048 16.2 0.1 1.5 1 0 0 1 1 1 1 AIG1 family zf_PR_Knuckle PF18445.1 CDK97224.1 - 0.024 14.5 0.7 0.057 13.2 0.7 1.6 1 0 0 1 1 1 0 PR zinc knuckle motif DDE_5 PF13546.6 CDK97226.1 - 3.1e-28 98.9 0.1 3.1e-28 98.9 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF927 PF06048.11 CDK97228.1 - 4.7e-44 151.1 0.0 1.1e-43 149.9 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF927) SUKH-3 PF14433.6 CDK97228.1 - 0.012 16.0 0.0 0.18 12.2 0.0 2.4 2 0 0 2 2 2 0 SUKH-3 immunity protein HTH_Tnp_IS630 PF01710.16 CDK97229.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK97229.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK97229.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK97229.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK97229.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK97229.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDK97230.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK97230.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain Response_reg PF00072.24 CDK97232.1 - 9.5e-22 77.3 0.2 1.2e-21 77.0 0.2 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Response_reg PF00072.24 CDK97233.1 - 2.2e-21 76.1 0.0 2.5e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain PHY PF00360.20 CDK97234.1 - 1.5e-36 125.4 0.0 2.8e-36 124.5 0.0 1.4 1 0 0 1 1 1 1 Phytochrome region HATPase_c PF02518.26 CDK97234.1 - 4.6e-28 98.0 0.1 9.6e-28 96.9 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK97234.1 - 2.6e-26 92.0 0.3 5.2e-26 91.0 0.3 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CDK97234.1 - 1.9e-23 82.3 1.4 1.4e-22 79.5 0.1 2.7 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 CDK97234.1 - 1.6e-11 45.0 0.0 5.7e-11 43.2 0.0 2.0 1 0 0 1 1 1 1 GAF domain Hpt PF01627.23 CDK97234.1 - 1.5e-09 38.0 0.9 1.5e-09 38.0 0.9 2.2 2 0 0 2 2 2 1 Hpt domain PAS_2 PF08446.11 CDK97234.1 - 1.8e-07 31.8 0.0 5.1e-07 30.3 0.0 1.9 1 1 0 1 1 1 1 PAS fold DUF1541 PF07563.11 CDK97234.1 - 0.15 11.9 0.9 0.36 10.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1541) Heme_oxygenase PF01126.20 CDK97235.1 - 7.3e-09 35.7 0.0 0.00021 21.1 0.0 2.0 2 0 0 2 2 2 2 Heme oxygenase SpoU_methylase PF00588.19 CDK97236.1 - 5.9e-39 133.5 0.1 8.5e-39 133.0 0.1 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 CDK97236.1 - 8.9e-09 35.5 0.0 2.3e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding UPF0253 PF06786.12 CDK97236.1 - 0.12 12.7 0.1 0.3 11.4 0.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0253) GTP_EFTU PF00009.27 CDK97237.1 - 1.1e-55 188.2 0.0 1.4e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDK97237.1 - 2.6e-33 114.7 0.0 5.9e-33 113.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDK97237.1 - 4.7e-17 62.1 5.8 1e-16 61.0 5.8 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDK97237.1 - 5.2e-05 23.3 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 CDK97237.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Lsm_C PF14894.6 CDK97237.1 - 0.37 10.6 3.7 0.76 9.6 3.7 1.5 1 0 0 1 1 1 0 Lsm C-terminal SecE PF00584.20 CDK97238.1 - 2.5e-19 69.0 7.3 2.8e-19 68.8 7.3 1.0 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex DUF2615 PF11027.8 CDK97238.1 - 0.087 13.0 0.4 0.096 12.8 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) NusG PF02357.19 CDK97239.1 - 1.6e-28 99.1 0.3 2.7e-28 98.3 0.3 1.4 1 0 0 1 1 1 1 Transcription termination factor nusG KOW PF00467.29 CDK97239.1 - 1.5e-07 31.1 0.5 6.5e-07 29.1 0.0 2.3 2 0 0 2 2 2 1 KOW motif Ribosomal_L11_N PF03946.14 CDK97240.1 - 1.7e-32 111.0 0.2 1.7e-32 111.0 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CDK97240.1 - 2.5e-27 95.2 1.4 4.3e-27 94.4 1.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain DEK_C PF08766.11 CDK97240.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 DEK C terminal domain Ribosomal_L1 PF00687.21 CDK97241.1 - 2.7e-57 193.8 0.0 3.5e-57 193.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family ResIII PF04851.15 CDK97241.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Ribosomal_L10 PF00466.20 CDK97242.1 - 2.8e-24 85.2 0.0 3.8e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_L12 PF00542.19 CDK97243.1 - 2.8e-30 104.4 11.9 2.8e-30 104.4 11.9 1.9 2 1 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CDK97243.1 - 1.8e-19 69.1 13.9 8.3e-18 63.8 12.5 2.5 2 0 0 2 2 2 2 Ribosomal protein L7/L12 dimerisation domain Ribosomal_60s PF00428.19 CDK97243.1 - 1.9 9.1 18.5 5.9 7.5 11.6 2.4 1 1 0 2 2 2 0 60s Acidic ribosomal protein RNA_pol_Rpb2_6 PF00562.28 CDK97244.1 - 8.2e-167 555.2 0.0 4.5e-166 552.7 0.0 2.2 2 1 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CDK97244.1 - 5.4e-33 114.2 0.0 1.3e-32 113.0 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 CDK97244.1 - 9.2e-33 112.2 0.0 1.9e-32 111.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 CDK97244.1 - 2.4e-27 95.2 0.1 6.2e-27 93.8 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_45 PF10385.9 CDK97244.1 - 1.9e-26 92.1 0.1 1.3e-25 89.5 0.1 2.5 2 0 0 2 2 2 1 RNA polymerase beta subunit external 1 domain RNA_pol_Rpb2_2 PF04561.14 CDK97244.1 - 7.8e-26 90.9 0.0 3.8e-19 69.0 0.1 2.4 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb1_1 PF04997.12 CDK97245.1 - 2.9e-91 306.1 0.0 4.6e-91 305.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 CDK97245.1 - 7.5e-74 248.5 0.3 1.9e-73 247.2 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CDK97245.1 - 7.3e-38 130.4 0.1 4.5e-27 95.3 0.0 3.1 2 1 1 3 3 3 2 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CDK97245.1 - 3.2e-21 75.9 0.0 1.1e-20 74.1 0.0 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CDK97245.1 - 8.6e-17 61.0 0.2 2.5e-16 59.6 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Apocytochr_F_C PF01333.19 CDK97245.1 - 0.00055 20.0 0.0 0.33 11.0 0.0 2.8 2 0 0 2 2 2 2 Apocytochrome F, C-terminal Biotin_lipoyl_2 PF13533.6 CDK97245.1 - 0.0061 16.4 0.0 7.2 6.5 0.0 3.8 4 0 0 4 4 4 1 Biotin-lipoyl like Peptidase_M23 PF01551.22 CDK97245.1 - 0.0084 16.3 0.0 0.34 11.2 0.0 3.5 4 0 0 4 4 4 1 Peptidase family M23 HATPase_c PF02518.26 CDK97246.1 - 1.8e-24 86.4 0.0 3.2e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK97246.1 - 5.4e-11 42.4 0.0 5.4e-11 42.4 0.0 2.5 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain dCache_1 PF02743.18 CDK97246.1 - 5.6e-10 39.4 0.0 9.7e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Cache domain HATPase_c_5 PF14501.6 CDK97246.1 - 0.022 14.7 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 GHKL domain PAS_4 PF08448.10 CDK97246.1 - 0.15 12.4 0.8 0.9 9.8 0.0 2.6 2 1 1 3 3 3 0 PAS fold LapA_dom PF06305.11 CDK97246.1 - 0.56 10.1 3.4 14 5.6 0.4 2.5 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain SLT PF01464.20 CDK97247.1 - 1.5e-06 27.9 0.0 3.4e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Transglycosylase SLT domain Phage_lysozyme2 PF18013.1 CDK97247.1 - 0.00097 19.2 0.0 0.0022 18.0 0.0 1.6 1 0 0 1 1 1 1 Phage tail lysozyme DUF5356 PF17309.2 CDK97247.1 - 0.16 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5356) Ribosom_S12_S23 PF00164.25 CDK97248.1 - 1.6e-44 150.2 0.6 1.8e-44 150.0 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S7 PF00177.21 CDK97249.1 - 8.9e-69 229.9 0.9 9.9e-69 229.7 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Nup153 PF08604.10 CDK97249.1 - 0.083 11.7 0.1 0.096 11.5 0.1 1.1 1 0 0 1 1 1 0 Nucleoporin Nup153-like GTP_EFTU PF00009.27 CDK97250.1 - 2.7e-70 235.9 0.0 4e-70 235.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDK97250.1 - 2e-45 153.5 0.2 3.9e-45 152.5 0.2 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 CDK97250.1 - 2.3e-34 117.3 0.1 4.7e-34 116.3 0.1 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CDK97250.1 - 6e-32 109.5 0.7 1.5e-31 108.3 0.1 2.1 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDK97250.1 - 9.1e-17 61.2 1.2 2.6e-16 59.8 0.2 2.3 3 0 0 3 3 3 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CDK97250.1 - 2.8e-05 23.9 0.1 5.8e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CDK97250.1 - 0.00059 19.9 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CDK97250.1 - 0.021 14.2 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 AIG1 family ANP PF00212.18 CDK97250.1 - 0.099 12.8 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Atrial natriuretic peptide GTP_EFTU PF00009.27 CDK97251.1 - 1.1e-55 188.2 0.0 1.4e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDK97251.1 - 2.6e-33 114.7 0.0 5.9e-33 113.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDK97251.1 - 4.7e-17 62.1 5.8 1e-16 61.0 5.8 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDK97251.1 - 5.2e-05 23.3 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 CDK97251.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Lsm_C PF14894.6 CDK97251.1 - 0.37 10.6 3.7 0.76 9.6 3.7 1.5 1 0 0 1 1 1 0 Lsm C-terminal Ribosomal_S10 PF00338.22 CDK97252.1 - 2.2e-37 127.2 0.2 2.4e-37 127.1 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Ribosomal_L3 PF00297.22 CDK97253.1 - 3e-18 65.9 8.0 4.5e-16 58.8 5.7 2.4 1 1 1 2 2 2 2 Ribosomal protein L3 Ribosomal_L4 PF00573.22 CDK97254.1 - 7.2e-65 218.3 0.3 8.1e-65 218.1 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribosomal_L23 PF00276.20 CDK97255.1 - 2e-32 111.4 1.2 2.4e-32 111.2 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L23 Ribosomal_L2_C PF03947.18 CDK97256.1 - 2.1e-58 196.0 2.2 3.1e-58 195.5 2.2 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CDK97256.1 - 1.4e-32 111.5 0.2 2.7e-32 110.6 0.2 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_S19 PF00203.21 CDK97257.1 - 1.3e-35 121.1 0.0 1.5e-35 120.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_L22 PF00237.19 CDK97258.1 - 8.6e-31 106.2 0.5 1e-30 106.0 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF1173 PF06666.11 CDK97258.1 - 0.052 12.5 0.7 0.055 12.4 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1173) Ribosomal_S3_C PF00189.20 CDK97259.1 - 6.3e-40 135.6 1.1 1.4e-39 134.5 1.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 CDK97259.1 - 9.3e-22 76.7 2.1 2.1e-21 75.5 2.1 1.6 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 CDK97259.1 - 0.021 14.7 0.2 0.044 13.7 0.2 1.5 1 0 0 1 1 1 0 KH domain Ribosomal_L16 PF00252.18 CDK97260.1 - 6e-49 165.4 0.2 6.8e-49 165.3 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Ribosomal_L29 PF00831.23 CDK97261.1 - 7e-23 80.4 3.1 8.3e-23 80.1 3.1 1.1 1 0 0 1 1 1 1 Ribosomal L29 protein MRP-L47 PF06984.13 CDK97261.1 - 0.08 13.1 0.2 0.099 12.8 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_S17 PF00366.20 CDK97262.1 - 1e-34 118.4 5.8 1.2e-34 118.3 5.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S17 DUF3850 PF12961.7 CDK97262.1 - 0.032 14.3 0.0 0.037 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) Ribosomal_L14 PF00238.19 CDK97263.1 - 2.1e-55 186.0 2.8 2.3e-55 185.9 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e ribosomal_L24 PF17136.4 CDK97264.1 - 7.2e-28 96.8 2.5 7.2e-28 96.8 2.5 1.4 2 0 0 2 2 2 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 CDK97264.1 - 1.3e-06 28.2 4.2 1.3e-06 28.2 4.2 2.7 3 1 0 3 3 3 1 KOW motif SH3_2 PF07653.17 CDK97264.1 - 0.012 15.3 0.5 1.5 8.6 0.1 2.3 1 1 1 2 2 2 0 Variant SH3 domain Ribosomal_L5_C PF00673.21 CDK97265.1 - 2.1e-41 140.0 0.0 3.4e-41 139.3 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CDK97265.1 - 7.3e-30 103.1 1.9 1.2e-29 102.4 1.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 Ribosomal_S14 PF00253.21 CDK97266.1 - 3.6e-20 71.5 0.7 6.1e-20 70.7 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Ribosomal_S8 PF00410.19 CDK97267.1 - 4.6e-45 152.7 0.0 5.1e-45 152.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S8 Corona_7 PF02398.16 CDK97267.1 - 0.17 12.5 0.0 14 6.3 0.0 2.1 2 0 0 2 2 2 0 Coronavirus protein 7 Ribosomal_L6 PF00347.23 CDK97268.1 - 2.1e-37 127.6 0.1 1.5e-18 67.3 0.0 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_L18p PF00861.22 CDK97269.1 - 4.2e-43 146.4 2.2 4.5e-43 146.3 2.2 1.0 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Ribosomal_S5_C PF03719.15 CDK97270.1 - 9.1e-30 101.9 0.4 1.5e-29 101.3 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 CDK97270.1 - 1.8e-29 101.5 5.0 3.3e-29 100.6 5.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_L30 PF00327.20 CDK97271.1 - 1.6e-18 66.3 0.2 1.8e-18 66.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L27A PF00828.19 CDK97272.1 - 1e-36 126.4 4.7 1.2e-36 126.2 4.7 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A SecY PF00344.20 CDK97273.1 - 3.5e-116 387.8 20.6 6.7e-116 386.8 20.3 1.5 2 0 0 2 2 2 1 SecY translocase PalH PF08733.10 CDK97273.1 - 0.081 11.9 0.0 0.22 10.5 0.0 1.9 1 1 0 1 1 1 0 PalH/RIM21 DUF3043 PF11241.8 CDK97273.1 - 0.57 10.2 2.2 0.71 9.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) ADK PF00406.22 CDK97274.1 - 5.1e-58 195.5 0.0 6.1e-58 195.2 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CDK97274.1 - 1.1e-22 80.9 0.8 1.2e-22 80.8 0.1 1.4 2 0 0 2 2 1 1 AAA domain ADK_lid PF05191.14 CDK97274.1 - 1.1e-12 47.7 0.7 2.1e-12 46.8 0.7 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 CDK97274.1 - 3.1e-05 24.2 0.0 5.8e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 CDK97274.1 - 0.00017 21.9 0.3 0.66 10.2 0.1 2.2 1 1 1 2 2 2 2 Hydin Adenylate kinase-like domain DUF1451 PF07295.11 CDK97274.1 - 0.0002 21.4 1.7 0.00034 20.7 1.7 1.3 1 0 0 1 1 1 1 Zinc-ribbon containing domain AAA_18 PF13238.6 CDK97274.1 - 0.00093 19.7 0.0 0.0027 18.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 CDK97274.1 - 0.018 14.7 0.1 0.028 14.1 0.1 1.3 1 0 0 1 1 1 0 Cytidylate kinase HypA PF01155.19 CDK97274.1 - 0.023 14.7 0.1 0.036 14.1 0.1 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ephrin_rec_like PF07699.13 CDK97274.1 - 0.074 12.8 1.5 0.14 12.0 1.5 1.4 1 0 0 1 1 1 0 Putative ephrin-receptor like Zn-ribbon_8 PF09723.10 CDK97274.1 - 0.078 13.1 2.4 0.14 12.3 2.4 1.4 1 0 0 1 1 1 0 Zinc ribbon domain Mg_chelatase PF01078.21 CDK97274.1 - 0.08 12.3 0.1 0.12 11.8 0.1 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Rubredoxin_2 PF18073.1 CDK97274.1 - 0.17 11.6 5.0 3.4 7.5 5.0 2.1 1 1 0 1 1 1 0 Rubredoxin metal binding domain Ribosomal_S13 PF00416.22 CDK97275.1 - 8.9e-35 119.9 7.3 3.2e-33 114.8 7.3 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 CDK97275.1 - 0.098 11.4 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Ribosomal_S11 PF00411.19 CDK97276.1 - 1.4e-49 167.1 0.8 1.6e-49 166.9 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 RNA_pol_A_CTD PF03118.15 CDK97277.1 - 7.5e-25 86.5 4.1 7.5e-25 86.5 1.6 2.2 2 0 0 2 2 2 1 Bacterial RNA polymerase, alpha chain C terminal domain RNA_pol_A_bac PF01000.26 CDK97277.1 - 2.4e-23 82.7 0.0 6.4e-23 81.3 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CDK97277.1 - 4.3e-22 77.3 0.0 8.1e-22 76.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF211 PF02680.14 CDK97277.1 - 0.0096 16.1 0.1 0.8 9.9 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized ArCR, COG1888 IDH PF03971.14 CDK97277.1 - 0.043 12.3 0.1 0.048 12.1 0.1 1.1 1 0 0 1 1 1 0 Monomeric isocitrate dehydrogenase Ribosomal_L17 PF01196.19 CDK97278.1 - 2.3e-36 124.6 0.0 2.8e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L17 ThiC_Rad_SAM PF01964.18 CDK97280.1 - 4.5e-199 661.5 0.0 5.2e-199 661.3 0.0 1.0 1 0 0 1 1 1 1 Radical SAM ThiC family ThiC-associated PF13667.6 CDK97280.1 - 1.2e-30 105.2 0.5 7.5e-30 102.6 0.1 2.5 3 0 0 3 3 3 1 ThiC-associated domain DUF1942 PF09167.11 CDK97281.1 - 0.0036 17.2 0.0 0.0055 16.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1942) Glyco_hydro2_C5 PF18565.1 CDK97281.1 - 0.16 11.8 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 GGDEF PF00990.21 CDK97282.1 - 2.1e-49 167.3 0.0 3.7e-49 166.6 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain dCache_1 PF02743.18 CDK97282.1 - 3.6e-19 69.5 0.0 5.6e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 Cache domain HAMP PF00672.25 CDK97282.1 - 1.3e-06 28.6 0.2 1.3e-06 28.6 0.2 2.7 3 0 0 3 3 3 1 HAMP domain Cache_3-Cache_2 PF17201.4 CDK97282.1 - 0.0048 16.2 0.0 0.0078 15.5 0.0 1.3 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain TetR_C_13 PF16925.5 CDK97283.1 - 4.6e-50 168.4 0.1 6.3e-50 167.9 0.1 1.2 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 CDK97283.1 - 6.2e-12 45.1 0.0 1e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_11 PF16859.5 CDK97283.1 - 8.8e-06 26.0 0.5 1.7e-05 25.1 0.5 1.6 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_6 PF13977.6 CDK97283.1 - 0.00021 21.5 0.1 0.00043 20.5 0.1 1.5 1 0 0 1 1 1 1 BetI-type transcriptional repressor, C-terminal TetR_C_7 PF14246.6 CDK97283.1 - 0.071 13.1 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 AefR-like transcriptional repressor, C-terminal domain DUF1707 PF08044.11 CDK97283.1 - 0.079 13.0 0.3 5.1 7.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) MtmB PF05369.12 CDK97283.1 - 0.16 10.7 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 Monomethylamine methyltransferase MtmB AT_hook PF02178.19 CDK97283.1 - 0.2 11.7 5.5 0.43 10.6 5.5 1.6 1 0 0 1 1 1 0 AT hook motif ADH_zinc_N PF00107.26 CDK97284.1 - 3.6e-13 49.6 0.3 8.2e-13 48.5 0.2 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDK97284.1 - 1.5e-05 24.8 0.3 9e-05 22.3 0.1 2.3 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CDK97284.1 - 0.00013 23.0 0.1 0.00021 22.4 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CDK97284.1 - 0.0067 15.9 0.2 0.012 15.1 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 CDK97284.1 - 0.073 12.5 0.0 0.099 12.1 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family AlaDh_PNT_C PF01262.21 CDK97284.1 - 0.095 12.0 4.0 0.036 13.4 1.2 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain CMD PF02627.20 CDK97285.1 - 3.1e-19 68.8 0.1 8.4e-19 67.4 0.3 1.6 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family PA26 PF04636.13 CDK97285.1 - 0.00016 20.7 0.0 0.00021 20.4 0.0 1.1 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) TAL_effector PF03377.13 CDK97285.1 - 0.0073 16.6 0.0 0.21 11.9 0.0 2.6 2 0 0 2 2 2 1 TAL effector repeat Exo_endo_phos PF03372.23 CDK97286.1 - 5.2e-13 49.1 0.3 6.9e-13 48.7 0.3 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CDK97286.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.7 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase DUF1045 PF06299.12 CDK97287.1 - 1e-54 184.8 4.3 1.2e-54 184.5 4.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1045) 2_5_RNA_ligase2 PF13563.6 CDK97287.1 - 1.6e-07 31.4 1.1 4e-07 30.1 1.0 1.8 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 CDK97287.1 - 3.6e-05 23.9 0.2 0.035 14.3 0.0 2.6 2 1 0 2 2 2 2 LigT like Phosphoesterase UTRA PF07702.13 CDK97288.1 - 9.3e-32 109.8 0.1 1.4e-31 109.3 0.1 1.3 1 0 0 1 1 1 1 UTRA domain GntR PF00392.21 CDK97288.1 - 4.4e-22 77.5 0.5 1e-21 76.3 0.1 1.8 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 CDK97288.1 - 8.5e-05 22.4 0.0 0.00032 20.6 0.0 1.9 1 0 0 1 1 1 1 HTH domain Fe_dep_repress PF01325.19 CDK97288.1 - 0.00043 20.4 0.0 1.4 9.2 0.1 2.5 2 0 0 2 2 2 2 Iron dependent repressor, N-terminal DNA binding domain Rrf2 PF02082.20 CDK97288.1 - 0.00064 20.0 0.0 0.0018 18.6 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulator TrmB PF01978.19 CDK97288.1 - 0.0015 18.4 0.1 0.0094 15.8 0.0 2.2 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 CDK97288.1 - 0.0048 16.8 0.4 0.19 11.6 0.0 2.6 2 0 0 2 2 2 1 MarR family MarR PF01047.22 CDK97288.1 - 0.0077 16.1 0.0 0.23 11.4 0.0 2.3 2 0 0 2 2 2 1 MarR family HTH_DeoR PF08220.12 CDK97288.1 - 0.0085 15.8 0.0 0.025 14.3 0.0 1.7 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_Crp_2 PF13545.6 CDK97288.1 - 0.019 15.0 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_41 PF14502.6 CDK97288.1 - 0.043 13.5 0.1 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain TFIIE_alpha PF02002.17 CDK97288.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 TFIIE alpha subunit PhnG PF06754.12 CDK97289.1 - 1.6e-57 193.4 1.0 1.8e-57 193.3 1.0 1.0 1 0 0 1 1 1 1 Phosphonate metabolism protein PhnG YwqJ-deaminase PF14431.6 CDK97289.1 - 0.18 12.0 0.1 0.26 11.5 0.1 1.3 1 0 0 1 1 1 0 YwqJ-like deaminase PhnH PF05845.12 CDK97290.1 - 6.9e-66 221.6 0.3 7.8e-66 221.4 0.3 1.0 1 0 0 1 1 1 1 Bacterial phosphonate metabolism protein (PhnH) PhnI PF05861.12 CDK97291.1 - 3.3e-166 552.5 0.0 3.8e-166 552.3 0.0 1.0 1 0 0 1 1 1 1 Bacterial phosphonate metabolism protein (PhnI) PhnG PF06754.12 CDK97291.1 - 0.00084 19.3 0.1 0.014 15.3 0.0 2.7 2 1 0 2 2 2 1 Phosphonate metabolism protein PhnG PhnJ PF06007.11 CDK97292.1 - 1.2e-149 496.8 0.0 1.4e-149 496.6 0.0 1.0 1 0 0 1 1 1 1 Phosphonate metabolism protein PhnJ ABC_tran PF00005.27 CDK97293.1 - 3e-27 95.8 0.0 3.9e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK97293.1 - 2.7e-08 34.0 0.0 0.0018 18.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system oligo_HPY PF08352.12 CDK97293.1 - 6.8e-06 26.5 0.0 1.1e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_16 PF13191.6 CDK97293.1 - 0.0012 19.3 0.7 0.0034 17.8 0.7 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDK97293.1 - 0.0012 18.5 0.0 0.0025 17.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDK97293.1 - 0.0018 18.2 0.0 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 CDK97293.1 - 0.0044 17.1 0.1 0.0083 16.2 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_25 PF13481.6 CDK97293.1 - 0.0053 16.4 0.3 0.013 15.1 0.3 1.8 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CDK97293.1 - 0.0068 16.9 0.0 0.0099 16.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDK97293.1 - 0.011 16.0 0.2 0.071 13.4 0.1 2.0 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 CDK97293.1 - 0.012 15.8 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 CDK97293.1 - 0.045 13.9 0.0 0.087 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain Propep_M14 PF02244.16 CDK97293.1 - 0.065 13.6 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Carboxypeptidase activation peptide AAA_24 PF13479.6 CDK97293.1 - 0.076 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDK97293.1 - 0.11 12.4 0.2 0.32 10.9 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PRK PF00485.18 CDK97293.1 - 0.15 11.8 0.1 0.24 11.1 0.1 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family cobW PF02492.19 CDK97293.1 - 0.18 11.4 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 CDK97293.1 - 0.19 11.2 0.0 3 7.2 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 CDK97294.1 - 2e-26 93.2 0.0 2.5e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDK97294.1 - 3e-07 30.1 0.0 5.6e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDK97294.1 - 3e-07 31.0 0.1 6e-07 30.0 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CDK97294.1 - 9.6e-07 28.9 0.0 0.045 13.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDK97294.1 - 0.00055 19.6 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDK97294.1 - 0.00096 19.1 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 CDK97294.1 - 0.0012 19.0 0.0 0.0032 17.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDK97294.1 - 0.0012 19.1 0.0 0.0021 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CDK97294.1 - 0.024 15.1 0.0 0.036 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDK97294.1 - 0.033 13.9 0.2 0.095 12.4 0.2 1.8 1 1 0 1 1 1 0 AAA domain AFG1_ATPase PF03969.16 CDK97294.1 - 0.036 13.0 0.0 1.8 7.4 0.0 2.2 2 1 0 2 2 2 0 AFG1-like ATPase AAA PF00004.29 CDK97294.1 - 0.065 13.7 0.0 0.19 12.1 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CDK97294.1 - 0.075 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain IstB_IS21 PF01695.17 CDK97294.1 - 0.079 12.7 0.1 0.51 10.0 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein Cytidylate_kin PF02224.18 CDK97294.1 - 0.11 12.3 0.1 0.2 11.4 0.0 1.5 2 0 0 2 2 2 0 Cytidylate kinase cobW PF02492.19 CDK97294.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 CDK97294.1 - 0.14 11.3 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain SbcCD_C PF13558.6 CDK97294.1 - 0.16 12.2 0.2 1.4 9.2 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Viral_helicase1 PF01443.18 CDK97294.1 - 0.18 11.5 0.0 0.31 10.7 0.0 1.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 CDK97294.1 - 0.18 12.3 0.0 0.33 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CDK97294.1 - 0.19 11.8 0.0 0.42 10.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Amidohydro_3 PF07969.11 CDK97295.1 - 5e-12 46.0 3.3 2.1e-08 34.1 0.6 2.4 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 CDK97295.1 - 5e-08 32.6 1.3 3.3e-07 29.9 0.0 2.3 2 1 0 2 2 2 1 Amidohydrolase family Prim-Pol PF09250.11 CDK97295.1 - 0.022 15.1 0.0 0.091 13.1 0.0 1.9 2 0 0 2 2 2 0 Bifunctional DNA primase/polymerase, N-terminal GGDEF PF00990.21 CDK97296.1 - 4.3e-45 153.4 0.0 7.6e-45 152.6 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain NMT1 PF09084.11 CDK97296.1 - 4.6e-39 134.6 0.0 7.4e-39 133.9 0.0 1.4 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 CDK97296.1 - 0.0088 15.8 0.0 0.055 13.1 0.0 2.0 2 0 0 2 2 2 1 NMT1-like family GGDEF_2 PF17853.1 CDK97296.1 - 0.013 15.7 0.7 0.013 15.7 0.7 2.8 1 1 1 2 2 2 0 GGDEF-like domain CcmD PF04995.14 CDK97296.1 - 0.014 15.5 3.4 0.039 14.0 3.4 1.8 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) HTH_18 PF12833.7 CDK97297.1 - 3.7e-16 59.2 0.7 7.1e-16 58.2 0.7 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CDK97297.1 - 9.6e-13 47.9 3.1 1.6e-09 37.6 0.1 3.5 4 0 0 4 4 4 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding_2 PF14525.6 CDK97297.1 - 5.2e-08 32.8 2.2 9.2e-08 32.0 2.2 1.4 1 0 0 1 1 1 1 AraC-binding-like domain HTH_7 PF02796.15 CDK97297.1 - 0.15 12.1 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase V-SNARE PF05008.15 CDK97298.1 - 0.022 15.1 0.0 0.035 14.5 0.0 1.3 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Flagellin_N PF00669.20 CDK97299.1 - 0.2 11.8 0.0 0.32 11.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region BPD_transp_1 PF00528.22 CDK97300.1 - 1.1e-18 67.7 10.5 1.1e-18 67.7 10.5 1.5 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component Phosphonate-bd PF12974.7 CDK97301.1 - 7.7e-59 199.2 0.1 9.4e-59 198.9 0.1 1.1 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein ABC_tran PF00005.27 CDK97302.1 - 1.4e-30 106.6 0.0 2e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK97302.1 - 1.2e-06 28.5 0.1 0.021 14.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDK97302.1 - 1.5e-05 24.6 0.1 4.4e-05 23.1 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDK97302.1 - 4.5e-05 23.9 0.5 0.0002 21.8 0.4 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDK97302.1 - 0.0012 19.1 0.1 0.02 15.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 CDK97302.1 - 0.0019 17.7 0.0 0.79 9.1 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDK97302.1 - 0.0028 17.6 0.0 0.018 14.9 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase NACHT PF05729.12 CDK97302.1 - 0.0042 17.0 0.1 0.0085 16.0 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 CDK97302.1 - 0.0043 17.2 1.4 0.015 15.5 1.4 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDK97302.1 - 0.011 15.4 0.5 0.03 14.0 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDK97302.1 - 0.016 14.8 0.0 0.037 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDK97302.1 - 0.021 15.0 0.2 0.052 13.8 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CDK97302.1 - 0.023 15.0 0.0 0.042 14.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 CDK97302.1 - 0.027 14.7 0.2 0.38 11.0 0.2 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 CDK97302.1 - 0.052 13.6 0.2 0.16 12.0 0.1 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_15 PF13175.6 CDK97302.1 - 0.066 12.9 0.0 1.5 8.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.14 CDK97302.1 - 0.15 12.0 0.1 0.35 10.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 CDK97302.1 - 0.17 12.3 0.0 0.28 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDK97302.1 - 0.23 12.0 0.1 0.38 11.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain Hexapep PF00132.24 CDK97303.1 - 4.6e-11 42.0 6.1 6e-08 32.1 6.8 3.3 3 0 0 3 3 3 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDK97303.1 - 2.3e-08 33.6 3.1 4.8e-08 32.6 3.1 1.6 1 0 0 1 1 1 1 Hexapeptide repeat of succinyl-transferase DUF2613 PF11021.8 CDK97303.1 - 0.016 15.3 3.7 0.032 14.3 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) MTS PF05175.14 CDK97304.1 - 4.5e-45 153.2 0.0 6.5e-44 149.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDK97304.1 - 1.3e-05 25.8 0.0 2.5e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 CDK97304.1 - 0.0012 18.6 0.0 0.0018 18.0 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 CDK97304.1 - 0.0022 17.8 0.0 0.0073 16.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDK97304.1 - 0.004 17.0 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Cons_hypoth95 PF03602.15 CDK97304.1 - 0.0046 16.6 0.0 0.019 14.6 0.0 1.9 2 0 0 2 2 2 1 Conserved hypothetical protein 95 MTS_N PF08468.11 CDK97304.1 - 0.01 15.9 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain N-terminal PCMT PF01135.19 CDK97304.1 - 0.026 14.3 0.0 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ADH_zinc_N_2 PF13602.6 CDK97304.1 - 0.054 14.6 0.0 0.94 10.5 0.0 2.2 2 0 0 2 2 2 0 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CDK97304.1 - 0.094 12.7 0.0 1.4 8.9 0.0 2.2 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 CDK97304.1 - 0.11 13.3 0.0 0.25 12.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 CDK97304.1 - 0.12 11.7 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PseudoU_synth_2 PF00849.22 CDK97305.1 - 2.4e-17 63.5 0.0 1.1e-16 61.3 0.0 1.9 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CDK97305.1 - 0.028 14.2 0.5 0.53 10.0 0.9 2.3 2 0 0 2 2 2 0 S4 domain DUF2015 PF09435.10 CDK97305.1 - 0.044 13.7 0.0 0.088 12.7 0.0 1.5 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2015) Flagellin_C PF00700.21 CDK97306.1 - 2.2e-08 34.3 1.6 2.2e-08 34.3 1.6 2.6 2 1 0 2 2 2 1 Bacterial flagellin C-terminal helical region Flagellin_N PF00669.20 CDK97306.1 - 2.2e-08 34.3 15.6 2.2e-08 34.3 15.6 2.2 2 0 0 2 2 2 1 Bacterial flagellin N-terminal helical region CHDCT2 PF08074.11 CDK97306.1 - 0.13 12.4 1.2 0.3 11.2 1.2 1.5 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain Flg_bbr_C PF06429.13 CDK97307.1 - 2.8e-07 30.6 3.4 4.2e-07 30.0 0.8 2.8 2 0 0 2 2 2 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CDK97307.1 - 0.00011 22.1 0.8 0.00011 22.1 0.8 3.2 4 0 0 4 4 4 1 Flagella basal body rod protein FlgN PF05130.12 CDK97308.1 - 3.9e-07 30.7 1.2 9.4e-06 26.2 1.2 2.0 1 1 0 1 1 1 1 FlgN protein DUF4132 PF13569.6 CDK97308.1 - 0.094 12.5 0.3 0.17 11.7 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4132) HalX PF08663.10 CDK97308.1 - 4.4 7.7 6.8 20 5.6 0.7 2.6 2 1 0 2 2 2 0 HalX domain SATase_N PF06426.14 CDK97309.1 - 0.1 13.0 2.8 0.18 12.2 2.8 1.5 1 1 0 1 1 1 0 Serine acetyltransferase, N-terminal Flg_bbr_C PF06429.13 CDK97310.1 - 5.3e-17 61.7 0.7 5.3e-17 61.7 0.7 2.6 2 0 0 2 2 2 1 Flagellar basal body rod FlgEFG protein C-terminal FlaE PF07559.14 CDK97310.1 - 1.6e-11 44.8 3.2 1.6e-11 44.8 3.2 2.8 1 1 1 2 2 2 1 Flagellar basal body protein FlaE Flg_bb_rod PF00460.20 CDK97310.1 - 3e-10 39.8 1.4 3e-10 39.8 1.4 2.5 3 0 0 3 3 3 1 Flagella basal body rod protein FlgD PF03963.14 CDK97311.1 - 5.7e-19 68.2 9.1 9.5e-19 67.5 9.1 1.3 1 0 0 1 1 1 1 Flagellar hook capping protein - N-terminal region FlgD_ig PF13860.6 CDK97311.1 - 2.7e-16 59.2 10.4 7.6e-16 57.8 8.6 2.2 2 0 0 2 2 2 1 FlgD Ig-like domain FLgD_tudor PF13861.6 CDK97311.1 - 1.8e-10 40.9 2.2 1.8e-10 40.9 2.2 1.8 2 0 0 2 2 2 1 FlgD Tudor-like domain DUF2271 PF10029.9 CDK97311.1 - 0.00013 21.7 0.1 0.00025 20.7 0.1 1.7 1 0 0 1 1 1 1 Predicted periplasmic protein (DUF2271) CHU_C PF13585.6 CDK97311.1 - 0.00019 21.4 0.2 0.00033 20.7 0.2 1.3 1 0 0 1 1 1 1 C-terminal domain of CHU protein family bMG3 PF11974.8 CDK97311.1 - 0.012 15.6 0.7 0.023 14.7 0.7 1.5 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain RHS PF03527.14 CDK97311.1 - 0.017 14.9 0.2 0.052 13.3 0.2 1.9 1 0 0 1 1 1 0 RHS protein Cadherin-like PF12733.7 CDK97311.1 - 2 9.0 8.5 1.5 9.4 2.8 3.1 2 1 1 3 3 3 0 Cadherin-like beta sandwich domain DUF1275 PF06912.11 CDK97314.1 - 9.1e-37 126.8 14.2 1.1e-36 126.6 14.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Glug PF07581.12 CDK97314.1 - 1.5 9.4 4.3 22 5.7 0.3 2.8 2 0 0 2 2 2 0 The GLUG motif DUF3379 PF11859.8 CDK97315.1 - 0.092 12.1 0.0 0.1 11.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3379) FliS PF02561.14 CDK97316.1 - 5.7e-25 87.8 0.1 6.4e-25 87.7 0.1 1.0 1 0 0 1 1 1 1 Flagellar protein FliS PT-HINT PF07591.11 CDK97316.1 - 0.032 14.5 0.0 0.057 13.7 0.0 1.4 1 0 0 1 1 1 0 Pretoxin HINT domain FliD_C PF07195.12 CDK97317.1 - 8.1e-46 156.4 5.6 8.1e-46 156.4 5.6 2.0 2 0 0 2 2 2 1 Flagellar hook-associated protein 2 C-terminus FliD_N PF02465.18 CDK97317.1 - 2.8e-14 53.6 3.2 2.8e-14 53.6 3.2 5.4 5 1 0 5 5 4 1 Flagellar hook-associated protein 2 N-terminus Flagellin_IN PF07196.13 CDK97317.1 - 3.8e-07 30.2 2.7 3.8e-07 30.2 2.7 3.5 4 0 0 4 4 4 1 Flagellin hook IN motif Herpes_UL6 PF01763.16 CDK97317.1 - 0.0068 15.0 0.1 0.017 13.7 0.0 1.7 2 0 0 2 2 2 1 Herpesvirus UL6 like Sec5 PF15469.6 CDK97317.1 - 0.012 15.4 0.0 0.012 15.4 0.0 2.8 3 1 1 4 4 4 0 Exocyst complex component Sec5 COG5 PF10392.9 CDK97317.1 - 0.27 11.4 10.4 1.3 9.2 0.3 3.3 3 0 0 3 3 3 0 Golgi transport complex subunit 5 FlaC_arch PF05377.11 CDK97317.1 - 0.66 10.4 7.4 27 5.2 0.3 4.0 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF2205 PF10224.9 CDK97317.1 - 0.68 10.0 4.9 1.7 8.7 0.1 3.3 3 0 0 3 3 3 0 Short coiled-coil protein AATF-Che1 PF13339.6 CDK97317.1 - 1 10.0 5.0 61 4.3 1.3 3.4 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor Syntaxin-6_N PF09177.11 CDK97317.1 - 1.3 9.6 11.4 2.9 8.5 0.3 3.7 3 1 0 3 3 3 0 Syntaxin 6, N-terminal PspA_IM30 PF04012.12 CDK97317.1 - 1.5 8.4 9.4 0.25 10.9 0.9 2.6 3 0 0 3 3 3 0 PspA/IM30 family Prefoldin PF02996.17 CDK97317.1 - 1.5 8.7 10.7 0.42 10.5 0.7 3.7 3 1 1 4 4 4 0 Prefoldin subunit Flagellin_N PF00669.20 CDK97318.1 - 2.9e-31 108.4 13.9 2.9e-31 108.4 13.9 3.6 3 1 1 4 4 4 1 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 CDK97318.1 - 1e-19 70.7 16.2 1.5e-19 70.1 7.2 3.7 3 0 0 3 3 3 1 Bacterial flagellin C-terminal helical region Tropomyosin PF00261.20 CDK97318.1 - 0.13 11.6 1.1 0.23 10.8 1.1 1.3 1 0 0 1 1 1 0 Tropomyosin GramPos_pilinD3 PF16570.5 CDK97318.1 - 0.36 11.6 3.3 3.1 8.5 0.1 2.5 2 0 0 2 2 2 0 Gram-positive pilin backbone subunit 3, Cna-B-like domain DUF2203 PF09969.9 CDK97318.1 - 0.39 11.4 2.8 25 5.6 1.6 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Sigma70_r2 PF04542.14 CDK97319.1 - 1.3e-20 72.9 1.1 1.3e-20 72.9 1.1 2.1 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 CDK97319.1 - 1e-15 57.1 0.2 2.9e-15 55.7 0.0 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 CDK97319.1 - 3.1e-09 36.2 0.4 6.6e-09 35.1 0.0 1.8 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 CDK97319.1 - 0.00034 20.6 1.6 0.00069 19.6 1.6 1.5 1 1 0 1 1 1 1 ECF sigma factor UPF0122 PF04297.14 CDK97319.1 - 0.0013 19.0 0.0 0.0023 18.2 0.0 1.4 1 0 0 1 1 1 1 Putative helix-turn-helix protein, YlxM / p13 like HTH_9 PF08221.11 CDK97319.1 - 0.067 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Sigma70_r3 PF04539.16 CDK97319.1 - 0.086 12.9 0.1 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Sigma-70 region 3 TnsD PF15978.5 CDK97319.1 - 0.087 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Tn7-like transposition protein D TPR_14 PF13428.6 CDK97319.1 - 0.52 11.3 0.1 0.52 11.3 0.1 3.3 4 1 0 4 4 4 0 Tetratricopeptide repeat Metal_resist PF13801.6 CDK97320.1 - 8.5e-23 80.9 5.9 1e-22 80.6 5.9 1.1 1 0 0 1 1 1 1 Heavy-metal resistance Sigma70_r2 PF04542.14 CDK97322.1 - 7.8e-21 73.6 0.7 1.6e-20 72.6 0.2 1.8 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 CDK97322.1 - 1.5e-12 47.0 0.2 2.4e-12 46.3 0.2 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 CDK97322.1 - 1.6e-07 30.7 0.2 2.7e-07 30.0 0.2 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 CDK97322.1 - 0.0084 16.0 0.6 0.092 12.6 0.6 2.1 1 1 0 1 1 1 1 ECF sigma factor HTH_23 PF13384.6 CDK97322.1 - 0.12 12.3 0.1 0.28 11.0 0.1 1.7 1 0 0 1 1 1 0 Homeodomain-like domain Amidase PF01425.21 CDK97324.1 - 2.3e-81 274.1 0.0 3.1e-81 273.6 0.0 1.1 1 0 0 1 1 1 1 Amidase GGACT PF06094.12 CDK97324.1 - 0.11 13.1 0.0 0.23 12.1 0.0 1.5 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like Nup214_FG PF18617.1 CDK97324.1 - 1.6 9.3 6.6 4.2 8.0 6.6 1.7 1 0 0 1 1 1 0 Nucleoporin Nup214 phenylalanine-glycine (FG) domain CT_A_B PF02626.15 CDK97325.1 - 2.2e-94 316.0 0.0 4e-94 315.1 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 CDK97325.1 - 1.4e-64 217.5 0.0 2.4e-64 216.7 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CT_C_D PF02682.16 CDK97325.1 - 3.7e-49 167.2 0.1 1.7e-48 165.1 0.0 2.1 3 0 0 3 3 2 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_N PF00289.22 CDK97325.1 - 5.8e-47 158.8 0.1 4.5e-46 155.9 0.0 2.2 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDK97325.1 - 1e-35 122.1 0.0 7.5e-35 119.3 0.0 2.5 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CDK97325.1 - 1.7e-15 56.6 0.1 4.6e-15 55.2 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CDK97325.1 - 3e-10 40.0 0.0 5.5e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 CDK97325.1 - 3.5e-09 36.3 0.0 0.00026 20.8 0.0 3.0 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.22 CDK97325.1 - 0.00012 21.7 0.0 0.0007 19.2 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain HlyD_3 PF13437.6 CDK97325.1 - 0.00015 22.4 0.9 0.3 11.8 0.0 3.1 3 0 0 3 3 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CDK97325.1 - 0.00042 19.6 0.0 0.46 9.7 0.0 2.3 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion RimK PF08443.11 CDK97325.1 - 0.0016 18.1 0.0 0.003 17.2 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 CDK97325.1 - 0.0029 17.7 0.0 0.0054 16.8 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 CDK97325.1 - 0.01 15.6 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon DUF2118 PF09891.9 CDK97325.1 - 0.053 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) GCV_H PF01597.19 CDK97325.1 - 0.16 11.8 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein DUF1989 PF09347.10 CDK97326.1 - 6e-62 208.2 0.0 7.1e-62 207.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) DUF1989 PF09347.10 CDK97327.1 - 4.1e-55 186.0 0.0 4.9e-55 185.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) ABC_tran PF00005.27 CDK97328.1 - 8.4e-31 107.3 0.0 1.3e-30 106.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK97328.1 - 2e-08 34.4 0.0 0.0018 18.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDK97328.1 - 5.2e-05 23.7 0.0 7.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CDK97328.1 - 0.00043 20.7 0.0 0.0063 16.9 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDK97328.1 - 0.0011 19.3 0.0 0.0044 17.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CDK97328.1 - 0.0033 17.3 0.0 0.0054 16.7 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 CDK97328.1 - 0.004 17.3 0.0 0.0063 16.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CDK97328.1 - 0.011 15.4 0.1 0.03 13.9 0.0 1.7 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDK97328.1 - 0.012 15.8 0.4 0.14 12.3 0.1 2.4 2 1 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 CDK97328.1 - 0.015 15.6 0.0 0.044 14.0 0.0 1.8 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Rad17 PF03215.15 CDK97328.1 - 0.049 13.5 0.1 0.13 12.1 0.1 1.7 2 0 0 2 2 2 0 Rad17 P-loop domain Zeta_toxin PF06414.12 CDK97328.1 - 0.06 12.6 0.0 0.099 11.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 CDK97328.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 CDK97328.1 - 0.077 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 CDK97328.1 - 0.097 12.7 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 CDK97328.1 - 0.11 12.1 0.0 0.57 9.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CDK97328.1 - 0.13 11.8 0.1 0.3 10.7 0.0 1.5 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 CDK97328.1 - 0.18 11.5 0.0 1.8 8.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CDK97328.1 - 0.19 11.4 0.0 1.5 8.5 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 CDK97328.1 - 0.19 11.8 0.0 0.4 10.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CDK97328.1 - 0.19 10.9 0.0 0.48 9.6 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain MMR_HSR1 PF01926.23 CDK97328.1 - 0.24 11.5 0.0 0.81 9.8 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.19 CDK97328.1 - 0.24 10.8 0.0 6.2 6.2 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDK97328.1 - 0.25 11.8 0.0 0.36 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain BPD_transp_1 PF00528.22 CDK97329.1 - 3.9e-18 65.8 16.8 3.9e-18 65.8 16.8 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component NMT1 PF09084.11 CDK97330.1 - 3.6e-10 40.1 4.3 5.9e-10 39.5 1.5 2.0 1 1 1 2 2 2 1 NMT1/THI5 like SBP_bac_3 PF00497.20 CDK97330.1 - 5.1e-05 22.8 2.4 0.00022 20.7 2.4 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Carboxyl_trans PF01039.22 CDK97331.1 - 3.1e-176 586.9 0.6 3.5e-176 586.7 0.6 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 CDK97331.1 - 0.011 15.2 1.6 0.027 14.0 0.0 2.1 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) Acetyltransf_5 PF13444.6 CDK97332.1 - 0.19 12.4 0.0 0.24 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain OAD_gamma PF04277.13 CDK97332.1 - 2.3 8.9 10.3 5.2 7.7 10.2 1.5 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Biotin_lipoyl PF00364.22 CDK97333.1 - 1.3e-16 60.1 2.3 1.3e-16 60.1 2.3 1.8 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDK97333.1 - 2.2e-13 49.8 1.3 9.2e-06 25.4 0.0 2.8 2 1 1 3 3 3 2 Biotin-lipoyl like HlyD_D23 PF16576.5 CDK97333.1 - 8.9e-07 28.3 2.0 0.0014 17.8 0.3 2.1 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CDK97333.1 - 5.7e-06 27.0 0.5 0.061 14.0 0.1 2.4 2 0 0 2 2 2 2 HlyD family secretion protein RnfC_N PF13375.6 CDK97333.1 - 1.3e-05 25.0 0.8 2.1e-05 24.4 0.8 1.4 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Peptidase_M23 PF01551.22 CDK97333.1 - 0.00019 21.5 1.2 0.084 13.1 0.1 2.7 1 1 1 2 2 2 2 Peptidase family M23 GCV_H PF01597.19 CDK97333.1 - 0.00043 20.2 0.4 0.00071 19.5 0.4 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein DUF2118 PF09891.9 CDK97333.1 - 0.0046 16.9 0.6 0.0085 16.1 0.2 1.7 2 1 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2118) PYNP_C PF07831.13 CDK97333.1 - 0.0081 15.8 0.6 0.65 9.7 0.2 2.2 1 1 1 2 2 2 1 Pyrimidine nucleoside phosphorylase C-terminal domain PhnA PF03831.14 CDK97333.1 - 0.018 14.9 0.1 0.03 14.2 0.1 1.3 1 0 0 1 1 1 0 PhnA domain TRAM PF01938.20 CDK97333.1 - 0.044 13.8 0.2 0.12 12.4 0.1 1.8 2 1 0 2 2 2 0 TRAM domain OAD_beta PF03977.13 CDK97334.1 - 1.1e-101 340.4 33.8 1.2e-101 340.2 33.8 1.0 1 0 0 1 1 1 1 Na+-transporting oxaloacetate decarboxylase beta subunit SNARE_assoc PF09335.11 CDK97335.1 - 6.7e-12 46.0 7.5 6.7e-12 46.0 7.5 1.8 3 0 0 3 3 3 1 SNARE associated Golgi protein HATPase_c PF02518.26 CDK97336.1 - 3.4e-29 101.6 0.0 6.4e-29 100.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_7 PF12860.7 CDK97336.1 - 3.2e-23 82.1 0.0 6.3e-10 39.2 0.0 3.3 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.7 CDK97336.1 - 6.8e-16 57.9 0.4 3.9e-07 29.9 0.0 4.0 3 0 0 3 3 3 3 PAS domain HisKA PF00512.25 CDK97336.1 - 9.3e-13 48.0 1.1 2.6e-11 43.4 0.0 3.6 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CDK97336.1 - 7.9e-11 42.0 0.0 2.5e-05 24.2 0.0 3.6 3 0 0 3 3 3 2 PAS fold PAS_4 PF08448.10 CDK97336.1 - 9.3e-10 38.7 7.7 0.00038 20.7 1.0 4.0 4 0 0 4 4 4 3 PAS fold HATPase_c_2 PF13581.6 CDK97336.1 - 0.0027 17.7 1.9 0.0028 17.6 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain HPTransfase PF10090.9 CDK97336.1 - 0.012 15.5 1.1 0.027 14.3 0.0 2.3 2 0 0 2 2 2 0 Histidine phosphotransferase C-terminal domain Cyt_bd_oxida_II PF02322.15 CDK97336.1 - 0.14 11.5 1.5 0.23 10.8 1.5 1.2 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II PFK PF00365.20 CDK97337.1 - 1.4e-49 168.9 0.0 1.9e-49 168.5 0.0 1.2 1 0 0 1 1 1 1 Phosphofructokinase BclA_C PF18573.1 CDK97337.1 - 0.0026 17.6 0.0 0.011 15.6 0.0 1.9 2 0 0 2 2 2 1 BclA C-terminal domain pRN1_helical PF13010.6 CDK97337.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Primase helical domain DUF1289 PF06945.13 CDK97338.1 - 2.5e-15 56.0 0.7 2.7e-15 55.9 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1289) Cas_CXXC_CXXC PF09706.10 CDK97338.1 - 0.11 12.8 0.0 0.11 12.8 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_CXXC_CXXC) DUF924 PF06041.11 CDK97339.1 - 1.4e-60 204.5 0.0 1.6e-60 204.3 0.0 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) ABC_membrane PF00664.23 CDK97340.1 - 6e-48 163.9 2.5 7.6e-48 163.5 2.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDK97340.1 - 6.1e-34 117.5 0.0 1.3e-33 116.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDK97340.1 - 3.1e-09 36.6 0.1 4.7e-07 29.5 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDK97340.1 - 5e-05 23.3 0.0 0.00023 21.1 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CDK97340.1 - 0.00023 21.6 0.1 0.00056 20.3 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CDK97340.1 - 0.0012 19.3 0.0 0.17 12.3 0.0 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CDK97340.1 - 0.0013 18.4 0.1 0.0028 17.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDK97340.1 - 0.0046 17.2 0.0 0.029 14.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 CDK97340.1 - 0.0051 15.7 0.3 0.079 11.7 0.0 2.2 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_24 PF13479.6 CDK97340.1 - 0.0062 16.3 0.0 0.014 15.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CDK97340.1 - 0.0081 16.4 0.4 3.9 7.7 0.1 2.5 1 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDK97340.1 - 0.0084 16.2 0.0 0.022 14.8 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_21 PF13304.6 CDK97340.1 - 0.027 14.3 0.3 0.43 10.3 0.1 2.1 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CDK97340.1 - 0.034 13.9 0.1 0.1 12.3 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDK97340.1 - 0.042 14.4 0.0 0.65 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDK97340.1 - 0.043 13.1 0.2 0.15 11.3 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 CDK97340.1 - 0.066 13.7 0.1 0.13 12.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDK97340.1 - 0.089 12.4 0.2 0.31 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CDK97340.1 - 0.15 11.7 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain DUF374 PF04028.13 CDK97341.1 - 3.7e-27 93.7 0.7 5.5e-27 93.1 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF374) Acyltransferase PF01553.21 CDK97341.1 - 0.067 12.8 0.0 0.091 12.4 0.0 1.2 1 0 0 1 1 1 0 Acyltransferase Glycos_transf_N PF04413.16 CDK97342.1 - 4.8e-56 189.2 0.0 1.8e-55 187.3 0.0 1.9 2 0 0 2 2 2 1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) Glyco_trans_1_2 PF13524.6 CDK97342.1 - 0.063 13.7 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Msg2_C PF12373.8 CDK97342.1 - 0.079 12.4 0.2 0.15 11.5 0.2 1.5 1 0 0 1 1 1 0 Major surface glycoprotein 2 C terminal LpxK PF02606.14 CDK97343.1 - 1.9e-84 283.6 0.0 2.3e-84 283.3 0.0 1.0 1 0 0 1 1 1 1 Tetraacyldisaccharide-1-P 4'-kinase Thymidylate_kin PF02223.17 CDK97343.1 - 0.0036 17.0 0.0 0.0052 16.5 0.0 1.3 1 0 0 1 1 1 1 Thymidylate kinase Glyco_transf_4 PF13439.6 CDK97343.1 - 0.0058 16.6 1.0 0.091 12.7 0.1 2.3 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Lip_A_acyltrans PF03279.13 CDK97344.1 - 2.6e-51 174.5 0.0 3.1e-51 174.3 0.0 1.0 1 0 0 1 1 1 1 Bacterial lipid A biosynthesis acyltransferase MYEOV2 PF15004.6 CDK97344.1 - 0.17 12.4 0.0 0.32 11.4 0.0 1.4 1 0 0 1 1 1 0 Myeloma-overexpressed-like DUF4040 PF13244.6 CDK97344.1 - 1.7 8.9 4.5 0.32 11.2 0.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4040) Aminotran_3 PF00202.21 CDK97345.1 - 6.1e-51 173.3 0.0 9.1e-51 172.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III CTP_transf_3 PF02348.19 CDK97345.1 - 9.2e-27 94.4 0.0 1.3e-26 93.9 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 CDK97345.1 - 5.3e-08 33.4 7.8 3.1e-07 30.9 3.3 2.7 2 1 0 2 2 2 1 MobA-like NTP transferase domain Aminotran_1_2 PF00155.21 CDK97345.1 - 0.0045 16.2 0.0 0.011 15.0 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II DUF2064 PF09837.9 CDK97345.1 - 0.18 11.7 0.6 1.1 9.1 0.3 2.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2064) YAcAr PF10686.9 CDK97345.1 - 1.1 9.3 5.0 3.4 7.7 1.0 3.0 3 0 0 3 3 3 0 YspA, cpYpsA-related SLOG family GFO_IDH_MocA PF01408.22 CDK97346.1 - 2.4e-10 41.3 0.1 3.6e-10 40.7 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_2 PF03446.15 CDK97346.1 - 4.1e-05 23.8 0.0 7.5e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CDK97346.1 - 9.6e-05 21.8 0.0 0.00016 21.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CDK97346.1 - 0.0002 21.9 0.1 0.00035 21.1 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 CDK97346.1 - 0.019 15.3 0.3 0.16 12.2 0.1 2.4 1 1 0 1 1 1 0 TrkA-N domain GFO_IDH_MocA_C PF02894.17 CDK97346.1 - 0.045 13.7 0.1 0.078 13.0 0.1 1.4 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain AlaDh_PNT_C PF01262.21 CDK97346.1 - 0.11 11.8 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Polysacc_synt_2 PF02719.15 CDK97347.1 - 1.2e-101 339.7 0.0 1.4e-101 339.5 0.0 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CDK97347.1 - 2.4e-23 82.9 0.3 2e-22 79.8 0.3 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDK97347.1 - 8.3e-19 67.6 0.0 1.7e-16 60.1 0.0 2.1 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CDK97347.1 - 2.2e-13 50.3 0.0 8.1e-12 45.2 0.0 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CDK97347.1 - 6.1e-12 45.2 0.1 2.1e-10 40.2 0.1 2.2 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CDK97347.1 - 8.8e-10 38.2 1.3 7.1e-06 25.4 0.4 3.0 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CDK97347.1 - 4.2e-09 36.6 0.2 6e-09 36.1 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CDK97347.1 - 2.4e-07 30.9 0.0 4.2e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CDK97347.1 - 3.6e-07 29.8 0.1 5.3e-07 29.3 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Semialdhyde_dh PF01118.24 CDK97347.1 - 0.00077 19.9 0.1 0.0037 17.7 0.0 2.1 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 CDK97347.1 - 0.00091 18.9 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Shikimate_DH PF01488.20 CDK97347.1 - 0.00096 19.2 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DUF585 PF04522.12 CDK97347.1 - 0.018 14.7 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF585) adh_short_C2 PF13561.6 CDK97347.1 - 0.018 14.6 0.2 0.029 13.9 0.2 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase DUF2977 PF11192.8 CDK97347.1 - 0.025 14.7 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2977) DapB_N PF01113.20 CDK97347.1 - 0.1 12.8 0.1 0.36 11.0 0.0 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus HetR_C PF18460.1 CDK97347.1 - 0.12 12.3 0.0 0.35 10.8 0.0 1.7 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain DUF2189 PF09955.9 CDK97351.1 - 6.1e-35 120.2 7.8 6.1e-35 120.2 7.8 2.2 2 0 0 2 2 2 1 Predicted integral membrane protein (DUF2189) GTA_holin_3TM PF11351.8 CDK97351.1 - 0.0013 19.2 0.4 0.0013 19.2 0.4 2.0 1 1 0 2 2 2 1 Holin of 3TMs, for gene-transfer release PLDc_N PF13396.6 CDK97351.1 - 0.042 13.8 0.6 0.042 13.8 0.6 3.1 3 1 1 4 4 4 0 Phospholipase_D-nuclease N-terminal ECH_1 PF00378.20 CDK97352.1 - 2.8e-49 167.7 0.2 3.1e-49 167.6 0.2 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDK97352.1 - 4e-33 115.3 0.2 4.6e-33 115.1 0.2 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase CoA_transf_3 PF02515.17 CDK97353.1 - 6.2e-107 357.9 0.0 7.4e-107 357.6 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III Aminotran_1_2 PF00155.21 CDK97354.1 - 5.1e-25 88.4 0.0 1.8e-24 86.6 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 CDK97354.1 - 0.014 14.3 0.0 0.018 13.9 0.0 1.1 1 0 0 1 1 1 0 Allinase Hydrolase PF00702.26 CDK97355.1 - 5.1e-08 33.5 0.1 1e-07 32.4 0.1 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDK97355.1 - 7.9e-06 26.1 0.0 1.5e-05 25.1 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 CDK97355.1 - 0.0025 18.3 0.2 0.0049 17.3 0.2 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDK97355.1 - 0.0091 16.0 0.0 0.064 13.3 0.0 2.3 2 1 1 3 3 3 1 HAD-hyrolase-like PsbY PF06298.11 CDK97355.1 - 0.41 10.6 1.6 0.78 9.7 1.6 1.4 1 0 0 1 1 1 0 Photosystem II protein Y (PsbY) DUF839 PF05787.13 CDK97357.1 - 3.7e-184 613.8 0.0 4.3e-184 613.5 0.0 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF839) Reg_prop PF07494.11 CDK97357.1 - 0.14 12.5 0.0 1.4 9.4 0.0 2.6 2 0 0 2 2 2 0 Two component regulator propeller Abhydrolase_6 PF12697.7 CDK97358.1 - 6.2e-20 72.8 18.6 7.3e-20 72.5 18.6 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDK97358.1 - 9e-20 70.9 0.4 1.2e-19 70.6 0.4 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDK97358.1 - 2.9e-13 50.1 3.2 1.7e-11 44.3 3.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 CDK97358.1 - 6.6e-08 32.6 0.7 0.0085 16.0 0.1 2.2 2 0 0 2 2 2 2 Serine hydrolase Thioesterase PF00975.20 CDK97358.1 - 1.3e-05 25.4 0.2 1.7e-05 25.1 0.2 1.4 1 1 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 CDK97358.1 - 0.00011 22.0 0.1 0.00085 19.1 0.1 2.1 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_5 PF12695.7 CDK97358.1 - 0.001 18.8 0.0 0.004 17.0 0.1 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family UPF0227 PF05728.12 CDK97358.1 - 0.0021 18.0 0.0 0.32 10.9 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) Aminotran_1_2 PF00155.21 CDK97359.1 - 7.8e-52 176.6 0.0 9e-52 176.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CDK97359.1 - 4e-07 28.9 0.0 5.7e-07 28.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CDK97359.1 - 5.4e-07 28.9 0.0 8e-07 28.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CDK97359.1 - 0.00012 21.6 0.0 0.00016 21.1 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family P-II PF00543.22 CDK97360.1 - 5.2e-43 145.8 0.5 5.9e-43 145.6 0.5 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF3240 PF11582.8 CDK97360.1 - 0.033 14.3 0.0 0.038 14.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3240) VbhA PF18495.1 CDK97360.1 - 0.037 13.9 0.2 0.3 11.0 0.0 2.2 2 0 0 2 2 2 0 Antitoxin VbhA VapB_antitoxin PF09957.9 CDK97360.1 - 0.35 10.8 2.0 0.78 9.7 0.2 2.4 3 0 0 3 3 3 0 Bacterial antitoxin of type II TA system, VapB Gln-synt_C PF00120.24 CDK97361.1 - 2.9e-137 457.3 0.0 3.5e-137 457.0 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CDK97361.1 - 2.6e-29 100.8 0.8 4.8e-29 99.9 0.8 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain UPF0016 PF01169.19 CDK97362.1 - 1.1e-38 131.4 23.8 8.2e-21 74.1 9.2 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 PEPcase PF00311.17 CDK97363.1 - 3.4e-266 885.3 0.0 4.1e-266 885.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.6 CDK97363.1 - 0.11 10.9 0.0 0.19 10.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Laminin_G_3 PF13385.6 CDK97364.1 - 7.8e-299 977.4 202.9 8.7e-30 103.9 7.9 18.9 17 0 0 17 17 16 14 Concanavalin A-like lectin/glucanases superfamily Big_9 PF17963.1 CDK97364.1 - 3.7e-78 258.4 163.5 1.2e-19 70.9 16.3 46.7 46 8 6 52 52 31 16 Bacterial Ig domain Cadherin_5 PF17892.1 CDK97364.1 - 1.9e-75 249.0 168.7 3.8e-14 52.5 3.3 24.6 23 4 1 24 24 24 14 Cadherin-like domain Laminin_G_2 PF02210.24 CDK97364.1 - 1.4e-42 145.2 17.4 1.4e-05 25.7 0.0 12.8 12 0 0 12 12 12 9 Laminin G domain Pentaxin PF00354.17 CDK97364.1 - 1.1e-36 126.3 24.8 2e-12 47.2 0.0 12.6 12 0 0 12 12 12 8 Pentaxin family Cadherin_4 PF17803.1 CDK97364.1 - 1.1e-22 80.4 84.1 1.2e-10 41.8 14.7 43.0 41 8 4 45 45 25 16 Bacterial cadherin-like domain Laminin_G_1 PF00054.23 CDK97364.1 - 6.7e-21 74.9 18.5 0.00061 20.0 0.0 10.9 12 0 0 12 12 12 6 Laminin G domain FecR PF04773.13 CDK97364.1 - 4.2e-10 40.1 0.6 1.3e-07 32.1 0.1 5.6 2 0 0 2 2 2 1 FecR protein Cadherin_3 PF16184.5 CDK97364.1 - 2.2e-06 27.6 7.5 0.41 10.7 0.3 7.8 9 0 0 9 9 9 2 Cadherin-like HemolysinCabind PF00353.19 CDK97364.1 - 5.9e-06 26.2 70.8 5.1e-05 23.2 12.7 9.4 7 1 0 7 7 7 4 RTX calcium-binding nonapeptide repeat (4 copies) Peptidase_M10 PF00413.24 CDK97364.1 - 1.2e-05 25.2 2.1 3.4e-05 23.7 0.0 2.9 2 0 0 2 2 2 1 Matrixin DUF4983 PF16356.5 CDK97364.1 - 0.0001 23.0 0.3 1.2 10.0 0.0 5.7 5 0 0 5 5 4 1 Domain of unknown function (DUF4983) DUF1080 PF06439.11 CDK97364.1 - 0.0013 18.9 14.9 3.1 7.8 0.1 8.2 8 0 0 8 8 8 2 Domain of Unknown Function (DUF1080) DUF411 PF04214.13 CDK97365.1 - 4.1e-26 90.7 0.7 4.8e-26 90.5 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF MCPsignal PF00015.21 CDK97367.1 - 2.4e-38 131.6 42.1 1.3e-36 126.1 19.8 3.0 2 1 0 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_3 PF14827.6 CDK97367.1 - 1e-34 120.2 0.0 4.2e-34 118.2 0.0 2.0 1 0 0 1 1 1 1 Double sensory domain of two-component sensor kinase HAMP PF00672.25 CDK97367.1 - 4.3e-12 46.2 0.2 4.3e-12 46.2 0.2 5.0 5 0 0 5 5 5 1 HAMP domain CZB PF13682.6 CDK97367.1 - 1.7e-09 37.9 0.1 5e-09 36.5 0.1 1.9 1 0 0 1 1 1 1 Chemoreceptor zinc-binding domain DUF1664 PF07889.12 CDK97367.1 - 0.01 15.9 16.6 4.5 7.3 0.2 6.0 4 2 2 6 6 6 0 Protein of unknown function (DUF1664) Vip3A_N PF12495.8 CDK97367.1 - 0.022 14.6 3.4 0.13 12.1 0.1 3.0 3 0 0 3 3 3 0 Vegetative insecticide protein 3A N terminal CHIP_TPR_N PF18391.1 CDK97367.1 - 0.4 11.5 2.3 0.85 10.4 1.0 2.3 2 0 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain HTH_15 PF12324.8 CDK97367.1 - 0.49 10.4 6.0 29 4.7 0.1 4.4 4 0 0 4 4 4 0 Helix-turn-helix domain of alkylmercury lyase BLOC1_2 PF10046.9 CDK97367.1 - 0.61 10.4 17.5 3.8 7.9 0.1 5.4 4 2 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 CDK97367.1 - 0.66 10.5 14.3 9.5 6.8 0.1 5.1 5 0 0 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 CDK97367.1 - 2.2 8.6 27.2 0.061 13.6 0.8 5.8 3 2 1 5 5 5 0 Bacterial protein of unknown function (DUF948) NPA PF16469.5 CDK97367.1 - 3.1 8.4 5.9 42 4.8 2.5 3.5 3 1 0 3 3 3 0 Nematode polyprotein allergen ABA-1 MFS_1 PF07690.16 CDK97368.1 - 4.4e-31 108.1 64.4 2.6e-29 102.2 45.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CDK97368.1 - 2.4e-05 23.8 46.0 7.5e-05 22.2 46.0 2.6 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 CDK97368.1 - 0.063 11.5 6.6 0.88 7.8 0.1 3.2 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF2306 PF10067.9 CDK97368.1 - 5.8 7.1 20.7 0.051 13.8 4.5 3.5 2 1 0 3 3 3 0 Predicted membrane protein (DUF2306) Molybdopterin PF00384.22 CDK97369.1 - 9.3e-34 117.1 0.0 1.9e-31 109.5 0.0 3.1 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Molybdop_Fe4S4 PF04879.16 CDK97369.1 - 2.5e-16 59.4 2.6 4.4e-16 58.6 2.6 1.4 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Fe4S4 domain Molydop_binding PF01568.21 CDK97369.1 - 1e-11 44.9 0.0 2.3e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain HnRNP_M PF11532.8 CDK97369.1 - 3.2 8.0 4.6 1.8 8.8 0.1 2.3 2 0 0 2 2 2 0 Heterogeneous nuclear ribonucleoprotein M Fer4_11 PF13247.6 CDK97370.1 - 7.1e-23 80.6 9.0 7.1e-23 80.6 9.0 1.8 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDK97370.1 - 2.3e-14 53.7 24.3 5.1e-07 30.2 6.8 2.8 2 2 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK97370.1 - 3.2e-11 42.8 34.1 2.3e-06 27.4 1.6 5.0 5 0 0 5 5 5 3 4Fe-4S binding domain Fer4_9 PF13187.6 CDK97370.1 - 1.1e-10 41.4 22.3 1.5e-05 25.1 6.1 2.7 2 1 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK97370.1 - 1.2e-10 41.3 25.3 3.9e-05 23.7 12.1 3.8 2 1 2 4 4 4 3 4Fe-4S dicluster domain Fer4 PF00037.27 CDK97370.1 - 1.8e-10 40.2 38.1 1.6e-07 30.9 2.2 5.4 6 0 0 6 6 6 3 4Fe-4S binding domain Fer4_2 PF12797.7 CDK97370.1 - 1e-09 37.9 36.2 2.1e-05 24.3 1.4 4.8 4 1 0 4 4 4 3 4Fe-4S binding domain Fer4_3 PF12798.7 CDK97370.1 - 4.7e-08 33.4 32.8 0.029 15.3 6.3 4.6 4 1 0 4 4 4 4 4Fe-4S binding domain Fer4_21 PF14697.6 CDK97370.1 - 0.00017 21.7 25.3 0.0053 16.9 9.3 3.9 4 1 0 4 4 4 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 CDK97370.1 - 0.00017 21.8 34.3 0.03 14.8 0.9 4.9 4 1 0 4 4 4 3 4Fe-4S binding domain Fer4_8 PF13183.6 CDK97370.1 - 0.0036 17.7 26.2 0.2 12.1 8.4 4.1 2 2 0 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDK97370.1 - 0.014 15.9 27.8 0.17 12.5 2.2 4.3 1 1 4 5 5 5 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 CDK97370.1 - 0.023 15.3 1.1 0.023 15.3 1.1 3.9 5 1 0 5 5 4 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_16 PF13484.6 CDK97370.1 - 0.045 14.7 26.0 7.7 7.5 0.7 4.6 3 1 1 4 4 4 0 4Fe-4S double cluster binding domain Fer4_18 PF13746.6 CDK97370.1 - 0.54 10.5 20.5 1 9.6 2.4 4.0 3 1 1 4 4 4 0 4Fe-4S dicluster domain DmsC PF04976.12 CDK97371.1 - 3.5e-31 108.7 23.9 4.1e-31 108.5 23.9 1.1 1 0 0 1 1 1 1 DMSO reductase anchor subunit (DmsC) HTH_3 PF01381.22 CDK97372.1 - 1.7e-12 47.2 0.0 2.9e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CDK97372.1 - 1.1e-09 38.5 0.1 2.5e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CDK97372.1 - 2.2e-08 34.0 0.0 4.5e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 CDK97372.1 - 1e-05 25.9 0.0 1.8e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain YdaS_antitoxin PF15943.5 CDK97372.1 - 0.0068 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Reo_sigmaC PF04582.12 CDK97372.1 - 0.061 13.6 0.0 0.081 13.2 0.0 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein C-terminal domain Phage_coat PF09063.10 CDK97372.1 - 0.089 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Phage PP7 coat protein PseudoU_synth_2 PF00849.22 CDK97373.1 - 1.2e-32 113.2 0.0 1.5e-32 112.9 0.0 1.1 1 0 0 1 1 1 1 RNA pseudouridylate synthase SHOCT PF09851.9 CDK97374.1 - 0.14 12.0 0.1 0.14 12.0 0.1 1.9 2 0 0 2 2 2 0 Short C-terminal domain MarR PF01047.22 CDK97374.1 - 0.14 12.1 0.1 0.68 9.9 0.1 2.1 2 0 0 2 2 2 0 MarR family ALF PF03752.13 CDK97374.1 - 0.18 11.8 1.4 0.51 10.3 1.4 1.8 1 0 0 1 1 1 0 Short repeats of unknown function TylF PF05711.11 CDK97375.1 - 6.2e-10 38.8 0.2 4.6e-07 29.4 0.0 2.2 1 1 0 2 2 2 2 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 CDK97375.1 - 5.9e-09 36.9 0.4 1.9e-08 35.2 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain TPR_19 PF14559.6 CDK97375.1 - 1.5e-05 25.4 10.7 0.013 16.0 0.7 3.9 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDK97375.1 - 0.00014 22.4 19.2 0.0026 18.4 0.2 4.7 1 1 4 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDK97375.1 - 0.00068 18.9 2.8 0.00068 18.9 2.8 1.5 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDK97375.1 - 0.00076 19.4 11.7 0.012 15.6 0.1 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF2802 PF10975.8 CDK97375.1 - 0.032 14.3 1.6 0.049 13.8 0.1 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) TPR_1 PF00515.28 CDK97375.1 - 0.12 12.2 0.1 0.12 12.2 0.1 3.8 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDK97375.1 - 0.18 12.1 10.5 2 8.8 3.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDK97375.1 - 0.3 11.2 5.0 2.4 8.4 0.6 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDK97375.1 - 6.3 7.0 11.1 1.3 9.2 0.5 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF87 PF01935.17 CDK97376.1 - 8.7e-08 32.5 0.0 1.3e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_22 PF13401.6 CDK97376.1 - 5e-07 30.1 0.0 1.1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDK97376.1 - 9e-05 22.9 0.7 9e-05 22.9 0.7 2.4 2 1 1 3 3 3 1 AAA ATPase domain AAA_30 PF13604.6 CDK97376.1 - 0.00047 19.9 0.7 0.00092 19.0 0.7 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CDK97376.1 - 0.0006 19.8 0.0 0.0015 18.5 0.0 1.7 1 0 0 1 1 1 1 NACHT domain TrwB_AAD_bind PF10412.9 CDK97376.1 - 0.0024 16.8 0.1 0.15 10.9 0.0 2.1 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain FtsK_SpoIIIE PF01580.18 CDK97376.1 - 0.0036 16.7 0.2 0.019 14.3 0.0 1.9 1 1 0 2 2 2 1 FtsK/SpoIIIE family LexA_DNA_bind PF01726.16 CDK97376.1 - 0.012 15.3 0.3 0.039 13.7 0.0 2.0 2 0 0 2 2 2 0 LexA DNA binding domain AAA_19 PF13245.6 CDK97376.1 - 0.016 15.5 0.0 0.032 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDK97376.1 - 0.034 14.0 0.1 0.076 12.9 0.1 1.6 1 1 0 1 1 1 0 RsgA GTPase AAA_33 PF13671.6 CDK97376.1 - 0.036 14.2 1.8 0.17 12.0 0.4 2.6 2 1 0 2 2 2 0 AAA domain HTH_8 PF02954.19 CDK97376.1 - 0.069 13.0 0.0 0.27 11.1 0.0 2.1 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family DUF2075 PF09848.9 CDK97376.1 - 0.2 10.8 0.1 0.49 9.6 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Zot PF05707.12 CDK97376.1 - 0.21 11.2 0.0 0.62 9.7 0.0 1.8 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) tRNA_edit PF04073.15 CDK97377.1 - 4.4e-23 81.7 0.2 5.4e-23 81.4 0.2 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain DUF1842 PF08896.10 CDK97378.1 - 2.3e-39 134.2 0.5 2.7e-39 133.9 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1842) RF-1 PF00472.20 CDK97379.1 - 9.6e-27 93.2 0.2 1.2e-26 92.9 0.2 1.0 1 0 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.9 CDK97379.1 - 0.055 13.9 0.0 0.066 13.6 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit protein Flagellin_N PF00669.20 CDK97381.1 - 6e-14 52.3 2.6 7.9e-14 51.9 2.6 1.1 1 0 0 1 1 1 1 Bacterial flagellin N-terminal helical region DotD PF16816.5 CDK97381.1 - 0.097 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 DotD protein Flagellin_C PF00700.21 CDK97382.1 - 8.1e-07 29.3 1.4 1.2e-06 28.8 1.4 1.3 1 0 0 1 1 1 1 Bacterial flagellin C-terminal helical region GGDEF PF00990.21 CDK97383.1 - 9.9e-49 165.2 0.2 1.9e-48 164.3 0.2 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain HAMP PF00672.25 CDK97383.1 - 0.018 15.4 0.1 0.067 13.6 0.1 2.0 1 0 0 1 1 1 0 HAMP domain GGDEF_2 PF17853.1 CDK97383.1 - 0.027 14.7 0.2 0.083 13.2 0.1 2.0 2 0 0 2 2 2 0 GGDEF-like domain DUF948 PF06103.11 CDK97383.1 - 9.9 6.5 10.1 16 5.9 0.8 3.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) HD_5 PF13487.6 CDK97385.1 - 1.8e-18 66.6 0.1 4e-18 65.4 0.1 1.7 1 0 0 1 1 1 1 HD domain GAF PF01590.26 CDK97385.1 - 1.6e-09 38.5 0.0 3.6e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 GAF domain dCache_1 PF02743.18 CDK97385.1 - 2.8e-09 37.1 0.0 8.2e-09 35.6 0.0 1.9 1 1 0 1 1 1 1 Cache domain HD PF01966.22 CDK97385.1 - 3.6e-07 30.4 0.0 0.0052 17.0 0.0 2.4 2 0 0 2 2 2 2 HD domain GAF_2 PF13185.6 CDK97385.1 - 8.4e-07 29.4 0.0 4e-06 27.2 0.0 2.2 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 CDK97385.1 - 0.0013 19.0 0.3 1.1 9.6 0.0 3.7 3 1 1 4 4 4 1 GAF domain HAMP PF00672.25 CDK97385.1 - 0.0032 17.8 0.0 0.0083 16.5 0.0 1.8 1 0 0 1 1 1 1 HAMP domain Bact_transglu_N PF08379.10 CDK97386.1 - 1.5e-21 77.0 0.8 2.9e-21 76.1 0.8 1.5 1 0 0 1 1 1 1 Bacterial transglutaminase-like N-terminal region Transglut_core PF01841.19 CDK97386.1 - 9.6e-19 67.9 0.0 1.6e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 CDK97386.1 - 0.044 13.3 0.0 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase-like domain CP_ATPgrasp_2 PF14403.6 CDK97387.1 - 4.1e-150 499.9 0.0 7.1e-150 499.1 0.0 1.4 1 0 0 1 1 1 1 Circularly permuted ATP-grasp type 2 CP_ATPgrasp_1 PF04174.13 CDK97387.1 - 1e-108 363.3 0.0 1.6e-108 362.7 0.0 1.3 1 0 0 1 1 1 1 A circularly permuted ATPgrasp Alpha-E PF04168.12 CDK97387.1 - 3.3e-59 201.1 6.7 4.9e-59 200.5 6.7 1.3 1 0 0 1 1 1 1 A predicted alpha-helical domain with a conserved ER motif. DUF2126 PF09899.9 CDK97388.1 - 0 1303.6 0.0 0 1303.3 0.0 1.0 1 0 0 1 1 1 1 Putative amidoligase enzyme (DUF2126) Bact_transglu_N PF08379.10 CDK97388.1 - 4e-30 104.5 0.3 4e-30 104.5 0.3 2.4 2 0 0 2 2 2 1 Bacterial transglutaminase-like N-terminal region Transglut_core PF01841.19 CDK97388.1 - 3.9e-19 69.2 0.0 7.7e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 CDK97388.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Transglutaminase-like domain EAL PF00563.20 CDK97389.1 - 2.1e-74 250.1 0.1 3.1e-74 249.5 0.1 1.3 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK97389.1 - 1.2e-53 181.1 0.0 2.1e-53 180.4 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain SBP_bac_3 PF00497.20 CDK97389.1 - 1.7e-31 109.4 0.0 7.5e-31 107.3 0.0 2.0 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 PAS_8 PF13188.7 CDK97389.1 - 9.9e-09 35.0 0.2 7.1e-08 32.3 0.1 2.4 2 0 0 2 2 2 1 PAS domain PAS_9 PF13426.7 CDK97389.1 - 1.9e-06 28.1 0.0 6.1e-06 26.4 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDK97389.1 - 3.8e-06 27.1 3.1 5.7e-06 26.6 0.2 3.0 3 0 0 3 3 3 1 PAS fold PAS PF00989.25 CDK97389.1 - 0.0015 18.5 0.5 0.26 11.3 0.1 3.3 2 1 0 2 2 2 1 PAS fold PgaD PF13994.6 CDK97389.1 - 0.037 14.1 0.1 0.074 13.1 0.1 1.4 1 0 0 1 1 1 0 PgaD-like protein DUF4381 PF14316.6 CDK97389.1 - 0.057 13.7 1.4 2.7 8.3 1.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) PAS_7 PF12860.7 CDK97389.1 - 0.38 10.9 2.2 1.5 9.0 0.1 3.2 4 1 0 4 4 4 0 PAS fold Zn-ribbon_8 PF09723.10 CDK97390.1 - 2.5e-14 53.1 0.8 3.3e-14 52.7 0.8 1.2 1 0 0 1 1 1 1 Zinc ribbon domain HypA PF01155.19 CDK97390.1 - 0.00011 22.2 0.2 0.00015 21.7 0.2 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA NOB1_Zn_bind PF08772.11 CDK97390.1 - 0.0007 19.7 0.0 0.00091 19.3 0.0 1.2 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_9 PF14369.6 CDK97390.1 - 0.00094 19.4 1.2 0.0013 18.9 1.2 1.2 1 0 0 1 1 1 1 zinc-ribbon Zn_ribbon_SprT PF17283.2 CDK97390.1 - 0.0011 18.9 0.3 0.0017 18.2 0.3 1.3 1 0 0 1 1 1 1 SprT-like zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 CDK97390.1 - 0.0013 18.7 0.2 0.17 11.9 0.0 2.2 2 0 0 2 2 2 1 Transposase zinc-ribbon domain Zn_Tnp_IS91 PF14319.6 CDK97390.1 - 0.0074 16.3 0.1 0.01 15.8 0.1 1.2 1 0 0 1 1 1 1 Transposase zinc-binding domain DUF1451 PF07295.11 CDK97390.1 - 0.019 15.0 0.3 0.025 14.6 0.3 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain zf_UBZ PF18439.1 CDK97390.1 - 0.058 13.0 1.9 3.9 7.1 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Ogr_Delta PF04606.12 CDK97390.1 - 0.079 13.0 0.5 4.1 7.5 0.1 2.3 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger PhnA_Zn_Ribbon PF08274.12 CDK97390.1 - 0.082 12.9 2.6 2.3 8.3 0.2 2.2 2 0 0 2 2 2 0 PhnA Zinc-Ribbon Prok-RING_1 PF14446.6 CDK97390.1 - 0.092 12.7 0.4 0.14 12.1 0.4 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 MCM_OB PF17207.3 CDK97390.1 - 0.1 12.5 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 MCM OB domain RNA_POL_M_15KD PF02150.16 CDK97390.1 - 0.11 12.4 1.6 1.1 9.2 0.1 2.2 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit TF_Zn_Ribbon PF08271.12 CDK97390.1 - 0.25 10.9 1.9 1.3 8.6 2.2 1.8 1 1 1 2 2 2 0 TFIIB zinc-binding zf-C2H2_4 PF13894.6 CDK97390.1 - 0.46 11.5 2.1 8.3 7.5 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger DUF35_N PF12172.8 CDK97390.1 - 2 8.4 5.6 1.3 9.0 0.2 2.6 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc_ribbon_4 PF13717.6 CDK97390.1 - 3 7.8 5.4 9.8 6.2 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain CoA_trans PF01144.23 CDK97391.1 - 8.8e-79 263.9 0.5 1e-78 263.7 0.5 1.0 1 0 0 1 1 1 1 Coenzyme A transferase CoA_trans PF01144.23 CDK97392.1 - 7.2e-43 146.5 0.5 8e-43 146.4 0.5 1.0 1 0 0 1 1 1 1 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 CDK97392.1 - 0.009 15.9 0.1 0.012 15.5 0.1 1.2 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain QRPTase_C PF01729.19 CDK97393.1 - 2.9e-27 95.5 0.1 3.7e-27 95.2 0.1 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 CDK97393.1 - 1.8e-21 76.0 0.1 3.7e-21 75.0 0.1 1.6 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain Cyclin_C_2 PF16899.5 CDK97393.1 - 0.0094 16.3 0.0 0.025 15.0 0.0 1.7 1 0 0 1 1 1 1 Cyclin C-terminal domain GHMP_kinases_N PF00288.26 CDK97393.1 - 0.018 15.3 1.6 0.018 15.3 1.6 2.5 3 0 0 3 3 3 0 GHMP kinases N terminal domain DUF347 PF03988.12 CDK97393.1 - 0.36 11.0 0.1 0.36 11.0 0.1 2.1 2 0 0 2 2 2 0 Repeat of Unknown Function (DUF347) Molybdopterin PF00384.22 CDK97394.1 - 5.1e-68 230.0 0.0 6.2e-68 229.7 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 CDK97394.1 - 2.5e-28 98.3 0.0 5e-28 97.3 0.0 1.5 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Molybdop_Fe4S4 PF04879.16 CDK97394.1 - 8e-16 57.8 0.6 1.6e-15 56.8 0.6 1.5 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Fe4S4 domain Fer2_BFD PF04324.15 CDK97394.1 - 3.4e-13 49.7 0.3 2.1e-12 47.2 0.7 2.1 2 0 0 2 2 2 1 BFD-like [2Fe-2S] binding domain Rieske PF00355.26 CDK97395.1 - 1.3e-13 50.7 0.0 1.5e-13 50.5 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 CDK97395.1 - 2.8e-12 46.5 0.0 3.2e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Pyr_redox_2 PF07992.14 CDK97396.1 - 2.5e-54 184.5 0.2 2.5e-54 184.5 0.2 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 CDK97396.1 - 3.9e-29 100.8 6.8 3.4e-16 59.3 1.5 3.1 3 0 0 3 3 2 2 BFD-like [2Fe-2S] binding domain NIR_SIR PF01077.22 CDK97396.1 - 3.1e-25 88.5 0.0 5.8e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Rubredoxin_C PF18267.1 CDK97396.1 - 9.9e-19 67.0 0.1 2.6e-18 65.7 0.1 1.7 1 0 0 1 1 1 1 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox PF00070.27 CDK97396.1 - 5.2e-17 62.2 3.3 3.1e-14 53.3 0.0 4.0 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR_ferr PF03460.17 CDK97396.1 - 5.3e-15 55.0 0.0 1.1e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Pyr_redox_3 PF13738.6 CDK97396.1 - 1.8e-06 27.4 0.0 5.5e-06 25.8 0.0 1.8 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDK97396.1 - 1.2e-05 24.6 2.2 0.00017 20.8 0.1 2.6 2 1 0 3 3 3 1 Glucose inhibited division protein A DAO PF01266.24 CDK97396.1 - 1.8e-05 24.5 3.3 0.1 12.2 0.8 4.0 3 1 1 4 4 4 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CDK97396.1 - 0.00014 21.0 0.6 0.013 14.6 0.0 3.0 2 1 1 3 3 3 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CDK97396.1 - 0.0011 19.1 0.1 0.48 10.7 0.1 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CDK97396.1 - 0.0046 16.1 4.6 0.031 13.3 0.1 3.2 3 0 0 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.21 CDK97396.1 - 0.0052 16.1 1.0 0.25 10.6 0.1 2.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 CDK97396.1 - 0.007 16.4 6.0 1.6 8.7 0.0 3.8 4 0 0 4 4 4 2 FAD-NAD(P)-binding HI0933_like PF03486.14 CDK97396.1 - 0.0075 15.0 1.0 9.6 4.8 0.1 3.9 5 0 0 5 5 5 1 HI0933-like protein K_oxygenase PF13434.6 CDK97396.1 - 0.026 13.7 0.0 0.73 8.9 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) ABC_tran PF00005.27 CDK97397.1 - 3.6e-32 111.7 0.0 5.4e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK97397.1 - 2.4e-06 27.6 0.3 0.035 13.9 0.0 2.4 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CDK97397.1 - 0.00032 20.7 0.1 0.00074 19.5 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 CDK97397.1 - 0.00043 20.6 0.1 0.0017 18.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDK97397.1 - 0.00059 20.3 0.2 0.00099 19.5 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDK97397.1 - 0.00063 19.4 0.1 0.0013 18.5 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CDK97397.1 - 0.00065 19.5 0.0 0.00081 19.2 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CDK97397.1 - 0.0076 16.4 0.0 0.017 15.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CDK97397.1 - 0.0082 16.7 0.2 0.015 15.8 0.2 1.3 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDK97397.1 - 0.025 14.0 0.2 0.26 10.7 0.1 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA PF00004.29 CDK97397.1 - 0.026 15.0 0.1 0.18 12.2 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 CDK97397.1 - 0.027 13.3 1.2 0.11 11.3 0.0 2.3 2 1 1 3 3 3 0 Predicted ATPase of the ABC class Rad17 PF03215.15 CDK97397.1 - 0.034 14.0 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_25 PF13481.6 CDK97397.1 - 0.04 13.5 0.1 0.98 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CDK97397.1 - 0.09 12.9 0.5 0.25 11.4 0.4 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.22 CDK97397.1 - 0.15 11.2 0.4 0.34 10.1 0.1 1.6 2 0 0 2 2 2 0 NB-ARC domain NMT1_2 PF13379.6 CDK97398.1 - 8.1e-78 261.6 0.1 1.2e-77 261.0 0.1 1.1 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 CDK97398.1 - 3.8e-07 30.3 0.0 7.3e-05 22.8 0.0 2.2 2 0 0 2 2 2 2 NMT1/THI5 like BPD_transp_1 PF00528.22 CDK97399.1 - 1.6e-24 86.7 17.2 2.6e-24 86.0 17.2 1.3 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component NMT1_2 PF13379.6 CDK97400.1 - 3.4e-101 338.2 2.2 5e-101 337.6 2.2 1.3 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 CDK97400.1 - 1e-06 28.9 0.0 0.017 15.1 0.0 2.2 2 0 0 2 2 2 2 NMT1/THI5 like ANTAR PF03861.14 CDK97401.1 - 1.9e-19 69.2 1.6 1.9e-19 69.2 1.6 3.3 3 0 0 3 3 3 1 ANTAR domain Response_reg PF00072.24 CDK97401.1 - 2.2e-13 50.3 0.2 4e-13 49.5 0.2 1.4 1 0 0 1 1 1 1 Response regulator receiver domain NAD_binding_10 PF13460.6 CDK97401.1 - 0.68 9.8 4.4 6.1 6.7 4.4 2.3 1 1 0 1 1 1 0 NAD(P)H-binding DUF520 PF04461.13 CDK97402.1 - 5.6e-62 208.6 3.6 6.3e-62 208.5 3.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF520) DUF1948 PF09185.10 CDK97402.1 - 0.015 15.1 0.3 0.022 14.6 0.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1948) Mga PF05043.13 CDK97402.1 - 0.13 12.9 0.0 0.25 11.9 0.0 1.5 1 0 0 1 1 1 0 Mga helix-turn-helix domain DUF2218 PF09981.9 CDK97402.1 - 0.14 12.5 0.3 1.9 8.9 0.0 2.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2218) STAS PF01740.21 CDK97403.1 - 1.8e-21 76.0 0.1 4.1e-10 39.3 0.0 2.1 1 1 0 2 2 2 2 STAS domain STAS_2 PF13466.6 CDK97403.1 - 1.6e-20 73.2 0.1 6.5e-09 36.0 0.0 2.2 2 0 0 2 2 2 2 STAS domain HATPase_c PF02518.26 CDK97404.1 - 4.5e-23 81.9 0.0 1e-22 80.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK97404.1 - 1.7e-21 76.5 0.0 6.1e-21 74.7 0.0 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CDK97404.1 - 1.3e-19 70.0 1.7 1.4e-19 69.8 0.2 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 CDK97404.1 - 3.6e-14 52.9 0.0 1.6e-13 50.8 0.0 2.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CDK97404.1 - 5.5e-11 42.5 0.0 1.4e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 CDK97404.1 - 1.1e-10 41.6 0.0 2.4e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDK97404.1 - 1.2e-07 31.9 0.0 3e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 PAS fold dCache_1 PF02743.18 CDK97404.1 - 2.9e-06 27.3 0.0 1.3e-05 25.2 0.0 2.1 2 0 0 2 2 2 1 Cache domain PAS_8 PF13188.7 CDK97404.1 - 0.023 14.7 0.0 0.078 13.0 0.0 1.9 1 0 0 1 1 1 0 PAS domain HATPase_c_2 PF13581.6 CDK97404.1 - 0.035 14.1 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain DUF4381 PF14316.6 CDK97404.1 - 1.2 9.3 3.5 9 6.5 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) HATPase_c PF02518.26 CDK97405.1 - 9.8e-24 84.0 0.0 2.7e-23 82.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_7 PF12860.7 CDK97405.1 - 1.1e-18 67.5 0.3 1.6e-15 57.3 0.0 3.2 3 1 0 3 3 3 2 PAS fold HisKA PF00512.25 CDK97405.1 - 3.4e-14 52.6 3.2 1.3e-13 50.7 0.0 3.3 3 1 0 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 CDK97405.1 - 2.4e-08 34.2 0.0 2.7e-07 30.8 0.0 2.7 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 CDK97405.1 - 1.6e-07 31.3 0.0 0.00031 20.7 0.0 3.3 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.7 CDK97405.1 - 2e-06 27.7 0.1 0.013 15.5 0.0 3.0 2 0 0 2 2 2 2 PAS domain PilJ PF13675.6 CDK97405.1 - 0.0011 19.0 1.2 0.0044 17.0 0.1 2.5 2 0 0 2 2 2 1 Type IV pili methyl-accepting chemotaxis transducer N-term HATPase_c_2 PF13581.6 CDK97405.1 - 0.0072 16.3 0.1 0.041 13.8 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain PAS_4 PF08448.10 CDK97405.1 - 0.44 10.8 6.1 2 8.7 0.1 4.3 4 1 1 5 5 5 0 PAS fold 4HBT PF03061.22 CDK97406.1 - 1.4e-12 47.8 0.0 2.1e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 CDK97406.1 - 3e-08 33.9 0.1 3.7e-08 33.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) 4HBT_3 PF13622.6 CDK97406.1 - 0.0019 18.5 0.1 0.0028 17.9 0.1 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Usp PF00582.26 CDK97407.1 - 2.1e-15 57.4 2.5 4.3e-08 33.8 0.0 3.6 4 0 0 4 4 4 3 Universal stress protein family Acyl-CoA_dh_1 PF00441.24 CDK97408.1 - 7e-53 178.9 4.4 1.4e-52 177.9 4.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CDK97408.1 - 3.1e-37 127.7 0.4 8.5e-37 126.3 0.4 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CDK97408.1 - 6.9e-29 100.8 4.1 1.6e-28 99.6 4.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CDK97408.1 - 3.5e-26 91.2 0.0 9e-26 89.9 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain DUF743 PF05332.11 CDK97408.1 - 0.18 11.8 0.2 0.44 10.6 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF743) Thiolase_N PF00108.23 CDK97409.1 - 7.4e-81 271.3 2.2 1e-80 270.8 2.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDK97409.1 - 9.7e-42 141.5 0.8 1.6e-41 140.8 0.2 1.7 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CDK97409.1 - 0.19 11.3 5.3 0.19 11.2 0.7 2.9 2 1 1 3 3 3 0 Beta-ketoacyl synthase, N-terminal domain Aldedh PF00171.22 CDK97410.1 - 3e-156 520.5 2.2 3.4e-156 520.4 2.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CDK97410.1 - 3.9e-06 26.5 0.1 1e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) Wtap PF17098.5 CDK97410.1 - 0.013 15.5 0.0 0.059 13.3 0.1 1.9 2 0 0 2 2 2 0 WTAP/Mum2p family LuxC PF05893.14 CDK97410.1 - 0.066 12.2 0.5 0.16 11.0 0.5 1.5 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) AMP-binding PF00501.28 CDK97411.1 - 8.5e-09 34.5 0.0 1.3e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C_2 PF14535.6 CDK97411.1 - 0.0002 21.6 0.0 0.00039 20.7 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ABC_tran PF00005.27 CDK97412.1 - 8e-26 91.2 0.0 1.4e-25 90.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK97412.1 - 3.7e-12 46.7 0.1 1.2e-05 25.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDK97412.1 - 5.9e-05 23.7 0.0 0.0001 22.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDK97412.1 - 0.00021 21.0 0.2 0.00039 20.1 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CDK97412.1 - 0.00066 19.2 0.0 0.011 15.2 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_27 PF13514.6 CDK97412.1 - 0.0011 18.6 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDK97412.1 - 0.0013 18.5 0.2 0.0076 16.0 0.2 1.9 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CDK97412.1 - 0.0058 16.4 0.0 0.0091 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 CDK97412.1 - 0.0099 15.8 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 CDK97412.1 - 0.03 14.2 0.3 0.054 13.4 0.3 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 CDK97412.1 - 0.06 12.9 0.6 0.39 10.3 0.3 2.2 2 1 0 2 2 2 0 AAA domain MukB PF04310.12 CDK97412.1 - 0.071 12.9 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 MukB N-terminal NACHT PF05729.12 CDK97412.1 - 0.097 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ABC_ATPase PF09818.9 CDK97412.1 - 0.22 10.3 0.5 3.2 6.4 0.4 2.4 3 0 0 3 3 3 0 Predicted ATPase of the ABC class Peripla_BP_6 PF13458.6 CDK97413.1 - 1.8e-73 248.2 7.6 2.2e-73 247.9 7.6 1.0 1 0 0 1 1 1 1 Periplasmic binding protein Peripla_BP_5 PF13433.6 CDK97413.1 - 1.5e-06 27.5 0.0 4.3e-06 26.0 0.0 1.8 1 1 0 1 1 1 1 Periplasmic binding protein domain FancD2 PF14631.6 CDK97413.1 - 0.17 9.2 0.1 0.23 8.8 0.1 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease BPD_transp_2 PF02653.16 CDK97414.1 - 2.8e-38 131.6 37.2 3.6e-38 131.3 37.2 1.2 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component BPD_transp_2 PF02653.16 CDK97415.1 - 1.5e-36 126.0 40.0 1.8e-36 125.7 40.0 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component FecCD PF01032.18 CDK97415.1 - 0.0028 16.7 23.5 0.0028 16.7 23.5 2.1 1 1 0 1 1 1 1 FecCD transport family AMP-binding PF00501.28 CDK97416.1 - 1.6e-75 254.3 0.0 2.1e-75 253.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme CMAS PF02353.20 CDK97416.1 - 0.08 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase ABC_tran PF00005.27 CDK97417.1 - 5.3e-31 108.0 0.0 7e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter BCA_ABC_TP_C PF12399.8 CDK97417.1 - 1.9e-08 34.1 0.0 3.1e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_23 PF13476.6 CDK97417.1 - 2.2e-05 25.1 0.3 3.8e-05 24.3 0.3 1.3 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 CDK97417.1 - 0.00086 19.2 0.1 0.14 12.0 0.1 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK97417.1 - 0.0045 16.4 0.7 0.096 12.1 0.2 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 CDK97417.1 - 0.0067 16.9 0.3 0.2 12.1 0.3 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CDK97417.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDK97417.1 - 0.024 15.0 0.0 0.031 14.7 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CDK97417.1 - 0.028 14.3 0.1 0.09 12.7 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 CDK97417.1 - 0.034 13.9 0.0 0.064 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 CDK97417.1 - 0.034 13.7 0.0 0.055 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDK97417.1 - 0.068 12.7 0.2 5.5 6.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 CDK97417.1 - 0.086 13.2 0.1 0.1 12.9 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CDK97417.1 - 0.11 12.2 0.3 0.27 10.9 0.1 1.6 2 0 0 2 2 2 0 AAA ATPase domain NAD_binding_2 PF03446.15 CDK97418.1 - 1.3e-49 168.4 6.8 1.8e-49 168.0 6.8 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CDK97418.1 - 6.9e-42 142.5 1.4 8.8e-42 142.2 0.1 1.8 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 CDK97418.1 - 1.1e-09 38.8 0.1 3.1e-09 37.3 0.1 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CDK97418.1 - 7.6e-06 25.4 0.3 1.3e-05 24.6 0.3 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CDK97418.1 - 0.002 18.0 0.1 0.0053 16.7 0.3 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 CDK97418.1 - 0.0034 17.0 0.2 0.0095 15.5 0.1 1.7 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Sacchrp_dh_NADP PF03435.18 CDK97418.1 - 0.011 16.0 0.4 0.28 11.5 0.1 2.2 1 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_C PF03720.15 CDK97418.1 - 0.02 15.3 0.0 0.036 14.5 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain CoA_binding PF02629.19 CDK97418.1 - 0.024 15.3 0.1 8.9 7.1 0.2 2.7 2 0 0 2 2 2 0 CoA binding domain NAD_binding_10 PF13460.6 CDK97418.1 - 0.043 13.7 2.2 0.075 12.9 1.9 1.5 1 1 0 1 1 1 0 NAD(P)H-binding NmrA PF05368.13 CDK97418.1 - 0.044 13.3 0.3 0.075 12.6 0.3 1.4 1 0 0 1 1 1 0 NmrA-like family TrkA_N PF02254.18 CDK97418.1 - 0.065 13.5 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 CDK97418.1 - 0.11 12.0 0.1 0.63 9.6 0.1 2.0 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Acyl-CoA_dh_1 PF00441.24 CDK97419.1 - 6.6e-47 159.5 3.1 9.7e-47 158.9 3.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CDK97419.1 - 5.1e-33 114.1 0.1 1.2e-32 112.9 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CDK97419.1 - 2.6e-27 94.9 0.0 6.4e-27 93.6 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CDK97419.1 - 7.9e-25 87.7 1.9 1.6e-24 86.7 1.9 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain FCD PF07729.12 CDK97420.1 - 8.7e-30 103.7 6.3 8.7e-30 103.7 6.3 1.8 2 0 0 2 2 2 1 FCD domain GntR PF00392.21 CDK97420.1 - 8.1e-17 60.6 1.3 2.1e-16 59.3 0.4 2.1 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family AMP-binding PF00501.28 CDK97421.1 - 1.1e-99 334.0 0.0 1.3e-99 333.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDK97421.1 - 1.2e-14 55.0 0.0 2.6e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ECH_2 PF16113.5 CDK97422.1 - 2e-122 408.9 0.0 2.2e-122 408.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CDK97422.1 - 1.2e-29 103.4 0.0 1.6e-29 103.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase adh_short PF00106.25 CDK97423.1 - 1.5e-44 151.9 5.7 1.8e-44 151.5 5.7 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDK97423.1 - 4.4e-41 141.0 3.8 5.6e-41 140.6 3.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDK97423.1 - 9e-08 32.2 4.6 2.5e-07 30.8 4.6 1.7 1 1 0 1 1 1 1 KR domain NAD_binding_7 PF13241.6 CDK97423.1 - 0.0036 17.7 0.9 0.092 13.2 2.8 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 CDK97423.1 - 0.015 15.6 2.2 0.055 13.7 1.3 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 CDK97423.1 - 0.025 13.7 0.7 0.042 13.0 0.7 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein TrkA_N PF02254.18 CDK97423.1 - 0.029 14.6 0.9 0.055 13.7 0.9 1.5 1 0 0 1 1 1 0 TrkA-N domain HHH_5 PF14520.6 CDK97423.1 - 0.051 14.2 1.8 0.13 12.9 1.0 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix domain Epimerase PF01370.21 CDK97423.1 - 0.06 12.8 1.6 0.13 11.7 1.6 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family UDPG_MGDP_dh_N PF03721.14 CDK97423.1 - 0.09 12.3 0.2 0.15 11.6 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 CDK97423.1 - 0.19 11.6 2.3 0.29 11.0 2.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 CDK97424.1 - 1.2e-83 280.3 0.4 1.4e-83 280.1 0.4 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDK97424.1 - 1.5e-36 126.6 1.2 2.6e-36 125.8 1.2 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 CDK97424.1 - 0.022 14.7 0.4 0.26 11.3 0.0 2.1 2 0 0 2 2 2 0 Peptidase family S49 SDH_sah PF01972.16 CDK97424.1 - 0.086 11.8 0.0 0.15 11.0 0.0 1.3 1 1 0 1 1 1 0 Serine dehydrogenase proteinase Trypsin_2 PF13365.6 CDK97425.1 - 4.6e-19 69.8 0.2 8e-19 69.0 0.2 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDK97425.1 - 7.2e-08 32.5 0.4 5.7e-07 29.6 0.4 2.0 1 1 0 1 1 1 1 Trypsin DUF3138 PF11336.8 CDK97425.1 - 0.06 12.0 1.6 0.081 11.5 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Peptidase_S46 PF10459.9 CDK97425.1 - 0.86 8.2 2.7 0.68 8.5 0.6 1.9 2 1 1 3 3 3 0 Peptidase S46 AAA_23 PF13476.6 CDK97426.1 - 0.00013 22.5 5.9 0.00014 22.5 5.9 1.1 1 0 0 1 1 1 1 AAA domain DUF812 PF05667.11 CDK97426.1 - 0.0079 15.1 10.9 0.0098 14.8 10.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF4407 PF14362.6 CDK97426.1 - 0.011 15.1 20.7 0.014 14.7 20.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CALCOCO1 PF07888.11 CDK97426.1 - 0.012 14.5 17.4 0.015 14.2 17.4 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.11 CDK97426.1 - 0.027 13.3 15.4 0.043 12.7 15.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein YjzC PF14168.6 CDK97426.1 - 0.12 12.7 0.1 0.23 11.8 0.1 1.4 1 0 0 1 1 1 0 YjzC-like protein Golgin_A5 PF09787.9 CDK97426.1 - 0.19 11.2 14.0 0.24 10.8 14.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 CENP-F_leu_zip PF10473.9 CDK97426.1 - 0.26 11.3 15.9 0.061 13.3 9.7 2.3 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 CDK97426.1 - 0.74 9.6 22.4 0.14 11.9 2.2 3.4 2 1 1 3 3 3 0 Septum formation initiator DUF3573 PF12097.8 CDK97426.1 - 1.6 7.5 4.3 2.9 6.6 4.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) DUF3450 PF11932.8 CDK97426.1 - 1.7 7.9 20.4 1.8 7.8 14.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ABC_tran_CTD PF16326.5 CDK97426.1 - 1.8 8.9 19.0 1.7 8.9 8.6 3.2 1 1 1 2 2 2 0 ABC transporter C-terminal domain FAM76 PF16046.5 CDK97426.1 - 1.9 7.8 11.8 2.5 7.4 11.8 1.2 1 0 0 1 1 1 0 FAM76 protein UPF0242 PF06785.11 CDK97426.1 - 2.1 8.4 12.7 8.6 6.4 12.7 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Bap31_Bap29_C PF18035.1 CDK97426.1 - 2.6 8.1 9.3 3 7.9 2.6 3.2 2 1 1 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain NPV_P10 PF05531.12 CDK97426.1 - 4.9 7.7 7.9 0.71 10.4 2.3 2.1 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4200 PF13863.6 CDK97426.1 - 5 7.5 24.3 0.53 10.7 2.2 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) DUF724 PF05266.14 CDK97426.1 - 8.7 6.1 13.2 1.3 8.8 5.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF724) CENP-H PF05837.12 CDK97426.1 - 9.1 6.7 17.4 0.56 10.6 11.2 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DivIC PF04977.15 CDK97427.1 - 0.00012 21.7 9.7 0.0083 15.9 0.6 3.3 3 0 0 3 3 3 1 Septum formation initiator Spc7 PF08317.11 CDK97427.1 - 0.0015 17.5 11.5 0.0022 16.9 11.5 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein bZIP_2 PF07716.15 CDK97427.1 - 0.0075 16.3 8.2 0.075 13.1 2.3 3.0 2 1 1 3 3 3 1 Basic region leucine zipper APG6_N PF17675.1 CDK97427.1 - 0.019 15.5 11.6 0.32 11.5 6.4 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF3251 PF11622.8 CDK97427.1 - 0.024 14.3 0.1 0.07 12.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Lzipper-MIP1 PF14389.6 CDK97427.1 - 0.025 14.9 0.3 0.06 13.6 0.3 1.7 1 1 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 DUF2680 PF10925.8 CDK97427.1 - 0.031 14.3 6.5 0.2 11.7 0.8 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2680) MEDS PF14417.6 CDK97427.1 - 0.035 13.9 1.2 0.056 13.3 1.2 1.4 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Tim17 PF02466.19 CDK97427.1 - 0.04 14.3 5.5 0.39 11.1 5.9 2.2 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family Csm1_N PF18504.1 CDK97427.1 - 0.062 13.7 9.0 0.12 12.8 0.7 2.9 2 1 1 3 3 3 0 Csm1 N-terminal domain GAS PF13851.6 CDK97427.1 - 0.09 12.1 11.4 0.17 11.2 4.5 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF5082 PF16888.5 CDK97427.1 - 0.18 12.1 12.2 3.5 7.9 0.5 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) HIP1_clath_bdg PF16515.5 CDK97427.1 - 0.2 12.3 7.6 5.9 7.6 2.9 3.0 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FlaC_arch PF05377.11 CDK97427.1 - 0.2 12.1 5.1 25 5.3 0.5 3.2 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Allexi_40kDa PF05549.11 CDK97427.1 - 0.26 10.8 1.4 0.39 10.2 1.2 1.4 1 1 0 1 1 1 0 Allexivirus 40kDa protein GPS2_interact PF15784.5 CDK97427.1 - 0.28 11.7 4.0 6.2 7.3 2.3 2.6 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain End3 PF12761.7 CDK97427.1 - 0.34 11.1 6.0 0.7 10.0 6.0 1.6 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Bacteriocin_IIc PF10439.9 CDK97427.1 - 0.35 11.0 20.9 0.63 10.2 20.9 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide DUF4094 PF13334.6 CDK97427.1 - 0.38 11.2 6.2 0.48 10.9 0.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) FliJ PF02050.16 CDK97427.1 - 0.4 10.9 12.7 0.034 14.4 4.0 2.4 2 1 1 3 3 2 0 Flagellar FliJ protein TMF_TATA_bd PF12325.8 CDK97427.1 - 0.42 10.8 10.0 0.25 11.6 2.1 3.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding TSC22 PF01166.18 CDK97427.1 - 0.45 10.9 3.0 3.4 8.1 0.4 3.0 2 1 1 3 3 3 0 TSC-22/dip/bun family DUF2730 PF10805.8 CDK97427.1 - 0.5 10.5 3.6 18 5.5 0.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) DUF724 PF05266.14 CDK97427.1 - 0.51 10.1 11.6 1.1 9.1 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF1664 PF07889.12 CDK97427.1 - 0.55 10.3 8.2 2.1 8.4 1.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 CDK97427.1 - 0.61 8.7 10.1 0.83 8.2 10.1 1.1 1 0 0 1 1 1 0 AAA domain Gly-zipper_YMGG PF13441.6 CDK97427.1 - 0.66 9.8 27.2 1.6 8.5 27.2 1.6 1 0 0 1 1 1 0 YMGG-like Gly-zipper DUF4140 PF13600.6 CDK97427.1 - 0.68 10.4 15.1 0.1 13.0 2.3 3.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) ATG16 PF08614.11 CDK97427.1 - 0.77 10.0 14.6 28 4.9 15.0 2.2 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 CDK97427.1 - 0.84 8.9 16.0 0.84 8.9 9.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Gly-zipper_Omp PF13488.6 CDK97427.1 - 0.98 9.5 27.7 4 7.5 27.7 2.0 1 1 0 1 1 1 0 Glycine zipper PRKG1_interact PF15898.5 CDK97427.1 - 1 10.3 10.1 11 7.0 6.5 2.7 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain TMF_DNA_bd PF12329.8 CDK97427.1 - 1.2 9.2 11.3 1 9.4 2.9 3.0 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding YabA PF06156.13 CDK97427.1 - 1.8 9.3 7.2 8.1 7.1 0.1 3.1 2 1 2 4 4 3 0 Initiation control protein YabA MerR-DNA-bind PF09278.11 CDK97427.1 - 1.8 9.2 9.3 1.7 9.3 0.8 3.3 2 1 0 3 3 3 0 MerR, DNA binding DUF4407 PF14362.6 CDK97427.1 - 2.1 7.6 18.9 0.62 9.4 3.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) FAM76 PF16046.5 CDK97427.1 - 2.2 7.6 7.4 3.8 6.8 7.4 1.3 1 0 0 1 1 1 0 FAM76 protein ABC_tran_CTD PF16326.5 CDK97427.1 - 3.1 8.1 15.7 0.6 10.4 1.9 3.4 1 1 1 3 3 3 0 ABC transporter C-terminal domain Atg14 PF10186.9 CDK97427.1 - 3.3 6.7 10.9 12 4.9 10.9 1.8 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 GTP-bdg_M PF16360.5 CDK97427.1 - 3.4 8.3 7.8 2.2 8.9 2.7 2.6 1 1 2 3 3 3 0 GTP-binding GTPase Middle Region ZapB PF06005.12 CDK97427.1 - 5.5 7.5 10.8 46 4.5 5.5 3.2 2 1 0 2 2 2 0 Cell division protein ZapB K-box PF01486.17 CDK97427.1 - 6.1 7.1 7.0 3.6 7.8 1.7 2.6 1 1 1 2 2 2 0 K-box region Osmo_CC PF08946.10 CDK97427.1 - 7.2 6.9 9.6 2.7 8.3 0.6 3.4 4 0 0 4 4 3 0 Osmosensory transporter coiled coil SlyX PF04102.12 CDK97427.1 - 7.2 7.3 10.1 7.2 7.3 0.5 3.5 2 1 1 3 3 3 0 SlyX TraT PF05818.12 CDK97427.1 - 7.6 6.1 13.9 15 5.1 13.9 1.6 1 1 0 1 1 1 0 Enterobacterial TraT complement resistance protein DUF16 PF01519.16 CDK97427.1 - 9.5 6.8 10.3 2.7e+03 -1.1 10.5 2.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 FGE-sulfatase PF03781.16 CDK97428.1 - 8.5e-29 100.9 0.1 2.6e-28 99.3 0.1 1.7 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 FtsX PF02687.21 CDK97429.1 - 1.4e-06 28.7 1.2 1.4e-06 28.7 1.2 3.0 3 0 0 3 3 3 1 FtsX-like permease family Colicin_V PF02674.16 CDK97429.1 - 0.051 13.6 10.7 0.2 11.6 0.0 2.8 3 0 0 3 3 3 0 Colicin V production protein MlaE PF02405.16 CDK97429.1 - 0.91 9.2 11.8 0.017 14.8 4.6 1.8 2 1 0 2 2 2 0 Permease MlaE ABC_tran PF00005.27 CDK97430.1 - 2.6e-23 83.1 0.0 3.5e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 CDK97430.1 - 8e-08 31.9 0.1 1.6e-07 31.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CDK97430.1 - 2.3e-07 31.0 1.8 0.014 15.2 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK97430.1 - 2.1e-05 24.1 0.0 0.12 11.8 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDK97430.1 - 0.00038 20.9 0.8 0.00087 19.7 0.8 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CDK97430.1 - 0.0026 18.3 0.0 0.0036 17.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 CDK97430.1 - 0.0042 16.1 0.1 0.0059 15.6 0.1 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB PIF1 PF05970.14 CDK97430.1 - 0.014 14.6 0.0 0.019 14.1 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase AAA_30 PF13604.6 CDK97430.1 - 0.039 13.7 0.1 0.046 13.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 CDK97430.1 - 0.04 13.0 0.0 0.055 12.5 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.6 CDK97430.1 - 0.096 13.2 0.0 0.15 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDK97430.1 - 0.1 12.9 0.3 0.47 10.7 0.1 1.9 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CDK97430.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 NTPase RsgA_GTPase PF03193.16 CDK97430.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 2 0 0 2 2 2 0 RsgA GTPase VWA_2 PF13519.6 CDK97431.1 - 1.2e-05 25.9 0.2 6e-05 23.6 0.0 2.3 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA PF00092.28 CDK97431.1 - 0.00051 20.3 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain TssR PF17643.1 CDK97431.1 - 0.0011 17.1 0.0 0.0037 15.3 0.0 1.9 2 1 0 2 2 2 1 Type VI secretion system, TssR Sel1 PF08238.12 CDK97432.1 - 7.3e-05 23.3 2.1 0.43 11.3 0.9 3.2 2 1 0 2 2 2 2 Sel1 repeat Trypan_PARP PF05887.11 CDK97432.1 - 0.00058 19.8 1.6 0.00058 19.8 1.6 1.9 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) CwsA PF10814.8 CDK97432.1 - 0.016 15.4 0.9 0.036 14.3 0.2 1.8 1 1 0 1 1 1 0 Cell wall synthesis protein CwsA DUF4366 PF14283.6 CDK97432.1 - 0.028 14.5 0.0 0.093 12.8 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) Virul_Fac PF10139.9 CDK97433.1 - 0 1122.5 0.0 0 1122.3 0.0 1.0 1 0 0 1 1 1 1 Putative bacterial virulence factor Phasin_2 PF09361.10 CDK97433.1 - 0.01 16.1 0.5 0.83 9.9 0.1 2.6 2 0 0 2 2 2 0 Phasin protein SrfB PF07520.11 CDK97434.1 - 0 1383.7 0.0 0 1383.5 0.0 1.0 1 0 0 1 1 1 1 Virulence factor SrfB VWA_2 PF13519.6 CDK97436.1 - 1.3e-11 45.0 0.0 2.8e-10 40.8 0.0 2.3 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CDK97436.1 - 0.00049 20.4 0.0 0.011 16.0 0.0 2.2 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 CDK97436.1 - 0.0085 15.5 0.2 0.31 10.4 0.0 2.6 2 1 1 3 3 3 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 CDK97436.1 - 0.018 15.0 0.0 0.12 12.3 0.0 2.1 2 0 0 2 2 2 0 von Willebrand factor type A domain DUF2681 PF10883.8 CDK97436.1 - 0.022 15.2 0.0 0.04 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Phage_Gp19 PF09355.10 CDK97436.1 - 0.067 13.6 0.1 0.19 12.2 0.1 1.7 1 0 0 1 1 1 0 Phage protein Gp19/Gp15/Gp42 PRCC PF10253.9 CDK97436.1 - 0.41 11.4 7.3 0.77 10.5 7.3 1.4 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting LysR_substrate PF03466.20 CDK97437.1 - 3.7e-45 153.9 3.2 7.1e-45 152.9 3.2 1.4 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDK97437.1 - 6.5e-17 61.2 1.8 1.2e-16 60.3 0.4 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR_2 PF12802.7 CDK97437.1 - 0.00032 20.5 0.3 0.0011 18.8 0.1 2.0 2 0 0 2 2 2 1 MarR family HTH_28 PF13518.6 CDK97437.1 - 0.0017 18.4 0.1 0.0066 16.6 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 CDK97437.1 - 0.0027 17.1 0.0 0.0063 15.9 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_30 PF13556.6 CDK97437.1 - 0.0073 16.1 0.5 0.015 15.1 0.5 1.4 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_AsnC-type PF13404.6 CDK97437.1 - 0.0099 15.7 0.2 0.021 14.7 0.2 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_IclR PF09339.10 CDK97437.1 - 0.025 14.4 1.1 0.059 13.2 1.1 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_8 PF02954.19 CDK97437.1 - 0.041 13.7 1.4 0.057 13.2 0.1 1.8 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family HTH_24 PF13412.6 CDK97437.1 - 0.064 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 CDK97437.1 - 0.15 11.9 0.0 0.41 10.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family TauE PF01925.19 CDK97438.1 - 1.5e-43 149.2 34.4 1.8e-43 148.9 34.4 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE MerC PF03203.14 CDK97438.1 - 4.4 7.8 23.4 0.1 13.0 5.9 2.7 2 1 0 2 2 2 0 MerC mercury resistance protein LPAM_2 PF13627.6 CDK97439.1 - 0.03 14.2 1.3 0.056 13.3 1.3 1.5 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site IspA PF04279.15 CDK97440.1 - 1.6e-57 194.6 7.1 1.7e-57 194.4 7.1 1.0 1 0 0 1 1 1 1 Intracellular septation protein A DUF3561 PF12084.8 CDK97440.1 - 0.35 10.9 8.1 0.12 12.4 3.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3561) MerC PF03203.14 CDK97440.1 - 1 9.8 11.8 2 8.9 10.8 2.0 1 1 0 1 1 1 0 MerC mercury resistance protein FtsX PF02687.21 CDK97440.1 - 1.7 9.2 11.1 0.17 12.4 6.3 1.9 2 1 0 2 2 2 0 FtsX-like permease family GGDEF PF00990.21 CDK97441.1 - 2.8e-45 154.0 0.1 3.6e-45 153.6 0.1 1.1 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GGDEF_2 PF17853.1 CDK97441.1 - 0.00077 19.7 0.5 0.0015 18.8 0.5 1.5 1 0 0 1 1 1 1 GGDEF-like domain Cation_ATPase_C PF00689.21 CDK97441.1 - 0.049 13.3 2.8 0.051 13.3 1.5 1.6 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus Aminotran_5 PF00266.19 CDK97442.1 - 4.2e-31 108.2 0.0 5.4e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CDK97442.1 - 0.0068 15.0 0.0 0.0098 14.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Herpeto_peptide PF14409.6 CDK97442.1 - 0.12 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Herpetosiphon Ribonuclease_T2 PF00445.18 CDK97443.1 - 1.7e-18 67.5 0.0 2.7e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease T2 family Asp-Al_Ex PF06826.12 CDK97444.1 - 2.3e-81 271.5 47.8 2.4e-45 154.3 13.7 2.2 2 0 0 2 2 2 2 Predicted Permease Membrane Region TrkA_C PF02080.21 CDK97444.1 - 1e-19 70.1 1.7 3.1e-11 42.9 0.1 2.4 2 0 0 2 2 2 2 TrkA-C domain SnoaL_2 PF12680.7 CDK97444.1 - 0.089 13.4 0.7 0.68 10.6 0.5 2.3 2 0 0 2 2 2 0 SnoaL-like domain EAL PF00563.20 CDK97445.1 - 1.8e-72 243.7 0.0 3.6e-72 242.7 0.0 1.5 2 0 0 2 2 2 1 EAL domain GGDEF PF00990.21 CDK97445.1 - 9.2e-43 145.8 0.0 2.6e-42 144.3 0.0 1.8 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDK97445.1 - 1.1e-09 38.5 0.0 2.5e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDK97445.1 - 4.5e-08 33.3 0.6 2.5e-07 30.9 0.1 2.6 3 0 0 3 3 3 1 PAS fold PAS PF00989.25 CDK97445.1 - 0.00042 20.3 0.0 0.0012 18.8 0.0 1.8 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDK97445.1 - 0.0015 18.5 0.0 0.019 15.0 0.0 2.6 2 0 0 2 2 2 1 PAS domain PAS_3 PF08447.12 CDK97445.1 - 0.0046 17.2 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 PAS fold DUF5056 PF16479.5 CDK97445.1 - 0.15 12.3 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5056) Response_reg PF00072.24 CDK97446.1 - 8.8e-21 74.2 0.0 3.5e-20 72.2 0.0 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CDK97446.1 - 1.3e-16 60.4 3.3 3.2e-16 59.1 0.2 3.0 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain 7TMR-DISM_7TM PF07695.11 CDK97446.1 - 6.2e-15 55.6 18.8 9.4e-15 55.1 18.8 1.2 1 0 0 1 1 1 1 7TM diverse intracellular signalling Hpt PF01627.23 CDK97446.1 - 8.7e-05 22.7 2.3 8.7e-05 22.7 2.3 2.6 2 1 0 2 2 2 1 Hpt domain Myco_arth_vir_N PF09610.10 CDK97446.1 - 0.33 11.1 1.7 0.6 10.2 0.0 2.3 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Rrf2 PF02082.20 CDK97447.1 - 7.5e-23 80.7 0.2 1.1e-22 80.2 0.2 1.1 1 0 0 1 1 1 1 Transcriptional regulator MarR_2 PF12802.7 CDK97447.1 - 0.00021 21.1 0.0 0.00041 20.2 0.0 1.5 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 CDK97447.1 - 0.001 18.9 0.0 0.0013 18.6 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 CDK97447.1 - 0.016 15.7 0.1 0.034 14.7 0.1 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain Sigma70_r4 PF04545.16 CDK97447.1 - 0.046 13.2 0.4 0.27 10.8 0.7 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_42 PF06224.12 CDK97447.1 - 0.051 13.1 0.0 0.066 12.7 0.0 1.3 1 1 0 1 1 1 0 Winged helix DNA-binding domain HTH_23 PF13384.6 CDK97447.1 - 0.086 12.7 0.1 0.21 11.4 0.1 1.7 2 0 0 2 2 2 0 Homeodomain-like domain HTH_29 PF13551.6 CDK97447.1 - 0.11 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Crp_2 PF13545.6 CDK97447.1 - 0.12 12.4 0.2 0.2 11.6 0.2 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain RPA_C PF08784.11 CDK97447.1 - 0.2 12.3 0.0 0.29 11.8 0.0 1.2 1 0 0 1 1 1 0 Replication protein A C terminal tRNA-synt_2 PF00152.20 CDK97448.1 - 3.1e-43 148.0 0.0 4.1e-43 147.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 CDK97448.1 - 0.027 14.0 0.1 0.22 11.0 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) DUF440 PF04269.12 CDK97448.1 - 0.043 14.1 0.0 0.086 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF440 PS-DH PF14765.6 CDK97448.1 - 0.066 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Polyketide synthase dehydratase Radical_SAM PF04055.21 CDK97449.1 - 3.8e-10 40.4 0.0 2.5e-09 37.7 0.0 2.0 1 1 0 1 1 1 1 Radical SAM superfamily LAM_C PF12544.8 CDK97449.1 - 1e-06 29.0 0.1 1.8e-06 28.2 0.1 1.3 1 0 0 1 1 1 1 Lysine-2,3-aminomutase Fer4_12 PF13353.6 CDK97449.1 - 1.9e-06 28.2 0.0 2.7e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CDK97449.1 - 3.1e-06 27.3 0.0 4.8e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain HAD_SAK_2 PF18143.1 CDK97450.1 - 0.0036 17.6 0.4 0.014 15.7 0.4 1.9 1 1 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins TipAS PF07739.13 CDK97450.1 - 0.14 12.7 0.0 0.2 12.2 0.0 1.2 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain PAS PF00989.25 CDK97451.1 - 3.3e-10 40.0 0.0 4.7e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDK97451.1 - 4.3e-09 36.5 0.0 6.7e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 CDK97451.1 - 5.6e-09 36.2 0.0 8.9e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDK97451.1 - 0.00013 22.2 0.0 0.00022 21.5 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK97451.1 - 0.013 15.6 0.0 0.033 14.2 0.0 1.7 1 1 0 1 1 1 0 PAS domain MCPsignal PF00015.21 CDK97452.1 - 1.4e-36 125.9 20.9 1.4e-36 125.9 20.9 3.5 3 1 0 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain CZB PF13682.6 CDK97452.1 - 6e-13 49.0 0.0 1.1e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 Chemoreceptor zinc-binding domain HAMP PF00672.25 CDK97452.1 - 0.022 15.2 0.2 0.022 15.2 0.2 4.2 4 1 1 5 5 5 0 HAMP domain BLOC1_2 PF10046.9 CDK97452.1 - 0.058 13.7 1.0 1.3 9.4 0.0 3.4 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 CDK97452.1 - 0.079 13.0 4.7 5.3 7.1 0.2 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF1129 PF06570.11 CDK97452.1 - 0.1 12.1 0.2 0.18 11.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF4150 PF13665.6 CDK97452.1 - 0.56 10.4 1.9 0.74 10.0 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4150) Elong-fact-P_C PF09285.11 CDK97453.1 - 3e-24 84.5 0.2 1.2e-23 82.6 0.1 2.0 2 0 0 2 2 2 1 Elongation factor P, C-terminal EFP_N PF08207.12 CDK97453.1 - 2.3e-20 72.4 0.3 5.2e-20 71.2 0.3 1.6 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain EFP PF01132.20 CDK97453.1 - 4.7e-19 68.2 0.1 1.3e-18 66.7 0.1 1.7 2 0 0 2 2 2 1 Elongation factor P (EF-P) OB domain DUF4241 PF14025.6 CDK97453.1 - 0.002 18.4 0.1 0.0029 17.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4241) Inositol_P PF00459.25 CDK97454.1 - 2.2e-66 224.1 0.0 2.6e-66 223.9 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family DDE_Tnp_1_2 PF13586.6 CDK97456.1 - 2.9e-23 82.0 0.0 4.5e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1 PF01609.21 CDK97456.1 - 2.2e-18 66.7 0.4 2.1e-16 60.3 0.4 2.0 1 1 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_3 PF13612.6 CDK97456.1 - 8.4e-10 38.9 0.0 1.1e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 Transposase DDE domain DUF4096 PF13340.6 CDK97457.1 - 1.2e-23 83.1 2.5 1.2e-23 83.1 2.5 1.6 2 0 0 2 2 2 1 Putative transposase of IS4/5 family (DUF4096) OmpA PF00691.20 CDK97458.1 - 3.7e-09 36.8 0.1 4.8e-09 36.5 0.1 1.1 1 0 0 1 1 1 1 OmpA family Pilus_CpaD PF09476.10 CDK97458.1 - 0.00025 20.9 0.0 0.00032 20.5 0.0 1.1 1 0 0 1 1 1 1 Pilus biogenesis CpaD protein (pilus_cpaD) Phage_NinH PF06322.11 CDK97458.1 - 0.065 13.1 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Phage NinH protein Apolipoprotein PF01442.18 CDK97459.1 - 0.013 15.4 0.8 0.013 15.4 0.8 1.7 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain MotA_ExbB PF01618.16 CDK97459.1 - 0.15 11.8 9.3 0.022 14.5 2.1 3.0 2 1 0 2 2 2 0 MotA/TolQ/ExbB proton channel family OmpA PF00691.20 CDK97460.1 - 2.8e-16 59.7 0.8 1.5e-15 57.4 0.0 2.5 3 0 0 3 3 3 1 OmpA family Atg14 PF10186.9 CDK97460.1 - 0.0055 15.8 4.8 0.0064 15.6 4.8 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 HAUS6_N PF14661.6 CDK97460.1 - 0.0092 15.6 5.4 0.015 14.9 5.4 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus EzrA PF06160.12 CDK97460.1 - 0.016 13.4 4.8 0.023 12.9 4.8 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DLP_helical PF18709.1 CDK97460.1 - 0.02 14.1 1.5 0.02 14.1 1.5 1.9 1 1 1 2 2 2 0 Dynamin-like helical domain Fez1 PF06818.15 CDK97460.1 - 0.032 14.7 6.3 0.053 14.0 6.3 1.4 1 0 0 1 1 1 0 Fez1 DUF2304 PF10066.9 CDK97460.1 - 0.038 14.2 0.4 0.068 13.4 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) DUF4357 PF14267.6 CDK97460.1 - 0.13 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4357) AAA_13 PF13166.6 CDK97460.1 - 0.14 10.8 3.8 0.16 10.6 3.8 1.1 1 0 0 1 1 1 0 AAA domain DUF4404 PF14357.6 CDK97460.1 - 0.23 12.1 0.3 0.23 12.1 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) OmpH PF03938.14 CDK97460.1 - 0.26 11.6 14.7 0.2 12.0 5.2 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF4763 PF15960.5 CDK97460.1 - 0.4 10.0 8.3 0.71 9.1 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) DUF4201 PF13870.6 CDK97460.1 - 0.58 9.9 10.8 2.8 7.7 10.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) MMPL PF03176.15 CDK97460.1 - 0.63 8.9 5.8 0.066 12.1 1.1 1.6 2 0 0 2 2 2 0 MMPL family Spc7 PF08317.11 CDK97460.1 - 1.2 7.9 10.6 2.2 7.1 10.6 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein HIP1_clath_bdg PF16515.5 CDK97460.1 - 1.3 9.7 16.7 6.6 7.4 14.5 2.5 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 UPF0242 PF06785.11 CDK97460.1 - 1.4 9.0 12.3 15 5.6 12.3 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GAS PF13851.6 CDK97460.1 - 1.6 8.0 13.9 12 5.2 13.9 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Golgin_A5 PF09787.9 CDK97460.1 - 3.3 7.1 14.2 1.2 8.5 1.5 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF4200 PF13863.6 CDK97460.1 - 3.7 8.0 15.5 1.4 9.3 11.9 2.1 2 1 0 2 2 1 0 Domain of unknown function (DUF4200) COG2 PF06148.11 CDK97460.1 - 4.7 7.3 10.5 1 9.5 2.0 2.6 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 TolA_bind_tri PF16331.5 CDK97460.1 - 4.9 7.3 19.7 0.11 12.5 2.7 2.8 2 1 1 3 3 2 0 TolA binding protein trimerisation Baculo_PEP_C PF04513.12 CDK97460.1 - 9.1 6.3 10.5 8.6 6.4 6.2 2.6 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PCuAC PF04314.13 CDK97461.1 - 9.8e-40 134.7 0.0 1.2e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 Copper chaperone PCu(A)C DUF2946 PF11162.8 CDK97462.1 - 0.00021 21.9 9.9 0.00029 21.5 9.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2946) FtsX PF02687.21 CDK97465.1 - 3.7e-13 49.8 0.1 3.7e-13 49.8 0.1 2.9 4 0 0 4 4 4 1 FtsX-like permease family ABC_tran PF00005.27 CDK97466.1 - 4.3e-27 95.3 0.0 5.6e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK97466.1 - 1.1e-07 32.0 0.1 0.0024 17.8 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDK97466.1 - 0.0002 21.0 0.0 0.00053 19.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 CDK97466.1 - 0.0028 17.8 0.2 0.011 15.9 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CDK97466.1 - 0.0038 17.8 0.0 0.0065 17.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDK97466.1 - 0.0048 17.3 1.0 0.015 15.7 1.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 CDK97466.1 - 0.01 15.6 1.4 0.22 11.2 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDK97466.1 - 0.014 14.9 0.6 0.041 13.4 0.0 1.9 2 1 0 2 2 2 0 AAA domain SMC_N PF02463.19 CDK97466.1 - 0.016 14.6 0.0 1.2 8.5 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain cobW PF02492.19 CDK97466.1 - 0.062 12.9 0.2 0.1 12.1 0.2 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CDK97466.1 - 0.064 13.5 0.8 0.49 10.7 0.3 2.1 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CDK97466.1 - 0.067 13.1 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 CDK97466.1 - 0.17 11.8 0.1 0.35 10.8 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 CDK97466.1 - 0.18 11.9 0.2 17 5.4 0.2 2.2 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CDK97466.1 - 0.22 11.2 0.0 5.1 6.7 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AhpC-TSA PF00578.21 CDK97468.1 - 1.2e-24 86.6 0.0 1.5e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDK97468.1 - 2.8e-20 72.5 0.0 3.4e-20 72.3 0.0 1.0 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 CDK97468.1 - 3.2e-09 37.0 0.0 4.2e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 CDK97468.1 - 5.5e-07 30.0 0.0 2.6e-06 27.8 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.20 CDK97468.1 - 9.1e-07 28.8 0.0 6.5e-05 22.9 0.1 2.1 1 1 1 2 2 2 1 Thioredoxin DSBA PF01323.20 CDK97468.1 - 0.0049 16.7 0.0 0.0062 16.3 0.0 1.2 1 0 0 1 1 1 1 DSBA-like thioredoxin domain AhpC-TSA_2 PF13911.6 CDK97468.1 - 0.17 12.1 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme ATPase-cat_bd PF12156.8 CDK97469.1 - 4.7e-05 24.0 0.1 5.5e-05 23.8 0.1 1.1 1 0 0 1 1 1 1 Putative metal-binding domain of cation transport ATPase Mem_trans PF03547.18 CDK97470.1 - 0.013 14.0 0.4 0.014 13.8 0.4 1.0 1 0 0 1 1 1 0 Membrane transport protein DUF3185 PF11381.8 CDK97470.1 - 0.039 14.0 0.3 0.08 13.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) E1-E2_ATPase PF00122.20 CDK97472.1 - 4.2e-53 179.6 5.0 8.6e-53 178.5 5.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CDK97472.1 - 1.3e-39 136.6 6.0 1.3e-39 136.6 6.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CDK97472.1 - 5.9e-10 39.4 0.1 5.2e-09 36.4 0.0 2.5 2 0 0 2 2 2 1 Heavy-metal-associated domain HAD PF12710.7 CDK97472.1 - 9.9e-06 26.1 0.3 4.6e-05 23.9 0.2 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDK97472.1 - 0.024 14.4 1.0 0.14 11.9 0.5 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DsbD_2 PF13386.6 CDK97473.1 - 2.2e-40 138.7 27.2 2.6e-40 138.5 27.2 1.0 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DsbD PF02683.15 CDK97473.1 - 1.7e-06 28.1 12.7 2.1e-06 27.8 12.7 1.2 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region NosL PF05573.12 CDK97474.1 - 3.5e-06 27.4 0.0 6.3e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 NosL TAT_signal PF10518.9 CDK97474.1 - 0.00029 20.5 3.3 0.00029 20.5 3.3 2.3 2 0 0 2 2 2 1 TAT (twin-arginine translocation) pathway signal sequence NosL PF05573.12 CDK97475.1 - 3e-31 108.5 0.0 4.1e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 NosL YHS PF04945.13 CDK97475.1 - 0.00084 19.4 1.1 0.0022 18.0 0.5 2.0 2 1 0 2 2 2 1 YHS domain ATPgrasp_YheCD PF14398.6 CDK97476.1 - 0.00032 20.0 0.0 0.018 14.3 0.0 2.4 2 1 1 3 3 3 2 YheC/D like ATP-grasp TTL PF03133.15 CDK97476.1 - 0.024 13.8 0.0 0.95 8.5 0.0 2.1 2 0 0 2 2 2 0 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 CDK97476.1 - 0.057 12.7 0.0 0.21 10.8 0.0 1.7 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp TonB_C PF03544.14 CDK97477.1 - 1.6e-21 76.5 0.0 2.8e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 Gram-negative bacterial TonB protein C-terminal TonB_2 PF13103.6 CDK97477.1 - 0.016 15.5 0.0 0.016 15.5 0.0 2.0 2 0 0 2 2 2 0 TonB C terminal Hydrolase_4 PF12146.8 CDK97478.1 - 5.8e-09 35.6 0.2 0.00063 19.1 0.1 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDK97478.1 - 3.2e-08 33.5 0.1 0.00019 21.2 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Cutinase PF01083.22 CDK97478.1 - 0.00085 19.3 0.1 0.0012 18.9 0.1 1.2 1 0 0 1 1 1 1 Cutinase Lipase_3 PF01764.25 CDK97478.1 - 0.002 18.0 0.0 0.0035 17.2 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) FSH1 PF03959.13 CDK97478.1 - 0.0023 17.6 0.0 0.0054 16.4 0.0 1.6 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 CDK97478.1 - 0.0061 16.1 0.2 0.014 15.0 0.2 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 CDK97478.1 - 0.015 15.1 0.1 0.13 12.0 0.1 2.3 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 CDK97478.1 - 0.026 15.1 4.7 0.6 10.7 1.2 2.5 1 1 2 3 3 3 0 Alpha/beta hydrolase family DUF5029 PF16432.5 CDK97478.1 - 0.036 13.6 0.2 0.05 13.1 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5029) DUF2974 PF11187.8 CDK97478.1 - 0.046 13.3 0.1 0.065 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Chlorophyllase2 PF12740.7 CDK97478.1 - 0.16 10.9 0.0 6.2 5.7 0.0 2.1 2 0 0 2 2 2 0 Chlorophyllase enzyme Thioesterase PF00975.20 CDK97478.1 - 0.16 12.1 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain HTH_3 PF01381.22 CDK97479.1 - 3.7e-09 36.5 0.0 8.8e-09 35.3 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 CDK97479.1 - 6.1e-09 36.1 0.3 9e-09 35.6 0.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CDK97479.1 - 1.7e-06 27.9 0.0 3.8e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain YdaS_antitoxin PF15943.5 CDK97479.1 - 0.0038 17.1 0.0 0.0072 16.2 0.0 1.4 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT MarR PF01047.22 CDK97479.1 - 0.0055 16.6 0.0 0.045 13.7 0.0 2.1 2 0 0 2 2 2 1 MarR family HTH_23 PF13384.6 CDK97479.1 - 0.0061 16.3 0.1 0.013 15.3 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_26 PF13443.6 CDK97479.1 - 0.007 16.8 0.0 0.015 15.7 0.0 1.6 1 1 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain MqsA_antitoxin PF15731.5 CDK97479.1 - 0.009 16.1 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 Antitoxin component of bacterial toxin-antitoxin system, MqsA Phage_CII PF05269.11 CDK97479.1 - 0.015 15.5 0.0 0.028 14.6 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage CII protein HTH_37 PF13744.6 CDK97479.1 - 0.057 13.4 0.0 0.11 12.5 0.0 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.7 CDK97479.1 - 0.073 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_Crp_2 PF13545.6 CDK97479.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain PAS_9 PF13426.7 CDK97479.1 - 0.13 12.6 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 PAS domain DUF4447 PF14590.6 CDK97479.1 - 0.15 11.8 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4447) Sigma70_r4_2 PF08281.12 CDK97479.1 - 0.15 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 EamA PF00892.20 CDK97480.1 - 5.1e-19 68.8 38.4 1.8e-09 37.9 15.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 CDK97480.1 - 0.18 10.9 3.3 0.081 12.1 0.2 1.9 2 0 0 2 2 2 0 Nucleotide-sugar transporter UAA PF08449.11 CDK97480.1 - 1.2 8.2 8.9 1.5 8.0 1.9 2.2 2 0 0 2 2 2 0 UAA transporter family DUF4347 PF14252.6 CDK97481.1 - 1.8e-46 158.0 2.7 4.3e-46 156.7 2.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) He_PIG PF05345.12 CDK97481.1 - 3.4e-16 59.1 26.0 3.2e-09 36.8 8.6 5.3 4 0 0 4 4 4 2 Putative Ig domain HemolysinCabind PF00353.19 CDK97481.1 - 3.2e-08 33.4 15.4 3.2e-08 33.4 15.4 3.4 3 0 0 3 3 3 1 RTX calcium-binding nonapeptide repeat (4 copies) PKD PF00801.20 CDK97481.1 - 0.024 14.5 6.1 0.049 13.5 0.5 3.8 2 0 0 2 2 2 0 PKD domain HYR PF02494.16 CDK97481.1 - 0.13 12.6 2.3 2.7 8.4 0.0 3.9 4 0 0 4 4 4 0 HYR domain OEP PF02321.18 CDK97482.1 - 6.2e-24 84.8 28.8 1.3e-16 61.0 10.3 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein HAUS2 PF15003.6 CDK97482.1 - 0.015 15.0 0.5 0.039 13.7 0.5 1.7 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 TPR_7 PF13176.6 CDK97482.1 - 0.87 9.8 5.1 0.83 9.8 0.2 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat HlyD_3 PF13437.6 CDK97483.1 - 1.1e-15 58.2 0.3 2.4e-14 53.9 0.1 2.4 2 1 0 2 2 2 1 HlyD family secretion protein HlyD_D23 PF16576.5 CDK97483.1 - 2.2e-14 53.2 0.2 4e-14 52.3 0.2 1.4 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK97483.1 - 2.3e-09 36.9 0.1 0.0037 17.0 0.0 2.7 2 0 0 2 2 2 2 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK97483.1 - 0.023 14.5 0.0 2.3 8.1 0.0 2.8 3 0 0 3 3 3 0 Biotin-requiring enzyme RNA_pol_I_A49 PF06870.12 CDK97483.1 - 0.037 12.9 0.2 3 6.6 0.0 2.1 1 1 1 2 2 2 0 A49-like RNA polymerase I associated factor Asp_Glu_race PF01177.22 CDK97484.1 - 3e-27 95.9 0.0 3.8e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase FIST PF08495.10 CDK97484.1 - 0.022 14.8 0.2 0.047 13.7 0.1 1.6 2 1 0 2 2 2 0 FIST N domain cNMP_binding PF00027.29 CDK97485.1 - 2.2e-14 53.3 0.1 3.6e-14 52.6 0.1 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 CDK97485.1 - 6.7e-14 51.6 0.1 1.7e-13 50.3 0.0 1.7 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_36 PF13730.6 CDK97485.1 - 0.00078 19.4 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain RP-C PF03428.13 CDK97485.1 - 0.018 14.7 0.1 0.033 13.9 0.1 1.5 1 0 0 1 1 1 0 Replication protein C N-terminal domain MarR_2 PF12802.7 CDK97485.1 - 0.11 12.4 0.5 0.37 10.7 0.0 2.2 3 0 0 3 3 3 0 MarR family HTH_8 PF02954.19 CDK97485.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_Crp_2 PF13545.6 CDK97486.1 - 3.7e-18 65.3 1.7 6.6e-18 64.5 1.7 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain cNMP_binding PF00027.29 CDK97486.1 - 8.4e-14 51.4 0.0 1.5e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain MarR_2 PF12802.7 CDK97486.1 - 0.002 18.0 1.0 0.0048 16.7 1.0 1.8 1 1 0 1 1 1 1 MarR family Crp PF00325.20 CDK97486.1 - 0.0028 17.3 0.0 0.0075 15.9 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory proteins, crp family HTH_24 PF13412.6 CDK97486.1 - 0.0055 16.2 0.3 0.025 14.2 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 CDK97486.1 - 0.16 12.0 0.1 0.84 9.6 0.0 2.1 2 0 0 2 2 2 0 MarR family DUF2249 PF10006.9 CDK97487.1 - 5.5e-25 87.0 1.1 1.6e-12 47.1 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2249) TusA PF01206.17 CDK97487.1 - 0.046 13.6 0.0 0.1 12.4 0.0 1.7 2 0 0 2 2 2 0 Sulfurtransferase TusA NnrS PF05940.12 CDK97488.1 - 0.00044 19.8 44.7 0.00044 19.8 44.7 2.2 2 0 0 2 2 2 1 NnrS protein Hemerythrin PF01814.23 CDK97489.1 - 1.1e-15 58.4 15.0 3e-12 47.3 7.6 1.6 1 1 1 2 2 2 2 Hemerythrin HHE cation binding domain Formyl_trans_N PF00551.19 CDK97491.1 - 2.9e-37 128.2 0.1 3.7e-37 127.8 0.1 1.1 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.25 CDK97491.1 - 8e-06 25.5 0.0 3.3e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 ACT domain ACT_6 PF13740.6 CDK97491.1 - 0.0012 18.7 0.7 0.0032 17.4 0.1 2.0 2 0 0 2 2 2 1 ACT domain FecR PF04773.13 CDK97493.1 - 1.9e-16 60.5 0.0 2.8e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 FecR protein DUF423 PF04241.15 CDK97494.1 - 4.9e-19 68.3 6.7 7.4e-19 67.8 6.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Response_reg PF00072.24 CDK97495.1 - 6.2e-26 90.8 0.2 6.8e-26 90.6 0.2 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Ribosomal_L33 PF00471.20 CDK97496.1 - 2.1e-14 53.7 0.1 2.4e-14 53.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L33 GGDEF PF00990.21 CDK97497.1 - 4e-36 124.2 0.1 2.8e-35 121.5 0.1 2.0 1 1 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Peptidase_S41 PF03572.18 CDK97498.1 - 2e-39 134.9 0.0 2.7e-39 134.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S41 PDZ_6 PF17820.1 CDK97498.1 - 1.1e-14 54.0 0.2 4.3e-14 52.1 0.2 2.1 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 CDK97498.1 - 1.5e-10 41.2 0.1 3e-10 40.3 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDK97498.1 - 1.2e-08 35.1 0.1 2.6e-08 34.1 0.1 1.6 1 0 0 1 1 1 1 PDZ domain RNB PF00773.19 CDK97499.1 - 1.7e-92 310.2 0.0 2.4e-92 309.7 0.0 1.1 1 0 0 1 1 1 1 RNB domain S1 PF00575.23 CDK97499.1 - 1.4e-07 31.8 0.0 6.7e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 S1 RNA binding domain CSD2 PF17876.1 CDK97499.1 - 2.9e-07 30.5 0.0 4.8e-06 26.7 0.0 2.4 2 0 0 2 2 2 1 Cold shock domain RVP PF00077.20 CDK97499.1 - 0.032 14.5 0.0 0.13 12.6 0.0 1.9 2 0 0 2 2 2 0 Retroviral aspartyl protease Mem_trans PF03547.18 CDK97500.1 - 4.6e-09 35.2 15.2 4.6e-09 35.2 15.2 2.0 2 0 0 2 2 2 1 Membrane transport protein SBF PF01758.16 CDK97500.1 - 0.00066 19.4 7.5 0.00066 19.4 7.5 2.3 3 1 0 3 3 3 1 Sodium Bile acid symporter family HPP PF04982.13 CDK97501.1 - 2.3e-35 121.4 16.4 2.3e-35 121.4 16.4 1.6 2 0 0 2 2 2 1 HPP family ArAE_1 PF06081.11 CDK97501.1 - 0.3 11.2 6.1 0.44 10.7 6.1 1.3 1 1 0 1 1 1 0 Aromatic acid exporter family member 1 cNMP_binding PF00027.29 CDK97502.1 - 4.8e-20 71.4 0.1 6.7e-20 71.0 0.1 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Patatin PF01734.22 CDK97503.1 - 5.4e-13 49.6 7.0 1.6e-12 48.1 6.3 2.2 2 1 0 2 2 2 1 Patatin-like phospholipase AbiEi_4 PF13338.6 CDK97503.1 - 0.047 13.9 0.0 16 5.8 0.0 3.4 2 1 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin DNA_processg_A PF02481.15 CDK97504.1 - 2.5e-73 245.8 0.0 3.1e-73 245.5 0.0 1.1 1 0 0 1 1 1 1 DNA recombination-mediator protein A DprA_WH PF17782.1 CDK97504.1 - 8.2e-18 64.3 4.1 8.2e-18 64.3 4.1 2.3 2 0 0 2 2 2 1 DprA winged helix domain MarR_2 PF12802.7 CDK97504.1 - 0.0047 16.8 0.7 0.0047 16.8 0.7 2.7 3 0 0 3 3 3 1 MarR family LDcluster4 PF18306.1 CDK97504.1 - 0.55 9.8 2.9 1.4 8.5 2.9 1.6 1 1 0 1 1 1 0 SLOG cluster4 family Topoisom_bac PF01131.20 CDK97505.1 - 2.9e-123 411.9 0.0 3.9e-123 411.5 0.0 1.2 1 0 0 1 1 1 1 DNA topoisomerase Toprim_C_rpt PF13368.6 CDK97505.1 - 1.7e-49 165.6 5.7 7.1e-18 64.4 0.1 4.5 4 0 0 4 4 4 3 Topoisomerase C-terminal repeat Toprim PF01751.22 CDK97505.1 - 4.2e-25 88.0 0.1 9.8e-25 86.8 0.1 1.7 1 0 0 1 1 1 1 Toprim domain zf-C4_Topoisom PF01396.19 CDK97505.1 - 3.2e-14 52.4 0.6 1.2e-13 50.6 1.0 1.8 2 0 0 2 2 2 1 Topoisomerase DNA binding C4 zinc finger Response_reg PF00072.24 CDK97506.1 - 3.4e-07 30.4 0.0 6.4e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain OTCace_N PF02729.21 CDK97507.1 - 1.6e-41 141.8 0.2 2.1e-41 141.4 0.2 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 CDK97507.1 - 1.1e-22 80.8 0.0 2.7e-22 79.5 0.0 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Amidohydro_1 PF01979.20 CDK97508.1 - 1.8e-19 70.3 0.1 2.7e-19 69.7 0.1 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CDK97508.1 - 9.7e-10 38.5 2.1 3.6e-07 30.0 0.0 3.1 3 0 0 3 3 3 2 Amidohydrolase family DHOase PF12890.7 CDK97508.1 - 2.9e-05 24.0 0.0 5.4e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Dihydro-orotase-like Plasmid_stab_B PF10784.9 CDK97508.1 - 0.077 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Plasmid stability protein G3P_acyltransf PF02660.15 CDK97509.1 - 5.9e-47 159.8 15.1 6.9e-47 159.5 15.1 1.0 1 0 0 1 1 1 1 Glycerol-3-phosphate acyltransferase MFS_4 PF06779.14 CDK97510.1 - 1.5e-79 267.9 41.4 1.8e-79 267.7 41.4 1.0 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_1 PF07690.16 CDK97510.1 - 1.8e-22 79.8 56.5 1.4e-15 57.1 46.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CDK97510.1 - 0.00068 18.0 0.1 0.00068 18.0 0.1 2.9 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 CDK97510.1 - 0.0075 15.2 0.7 0.0075 15.2 0.7 3.1 2 1 1 3 3 3 2 Sugar (and other) transporter LysR_substrate PF03466.20 CDK97511.1 - 8.9e-43 146.1 3.0 8.9e-43 146.1 3.0 1.5 2 0 0 2 2 2 1 LysR substrate binding domain HTH_1 PF00126.27 CDK97511.1 - 2.4e-19 69.0 0.4 5.4e-19 67.9 0.4 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HD PF01966.22 CDK97512.1 - 2.1e-20 73.1 0.0 4.3e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 HD domain Response_reg PF00072.24 CDK97512.1 - 6.9e-17 61.6 0.0 1.3e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HD_5 PF13487.6 CDK97512.1 - 3.2e-14 52.9 0.0 1.1e-13 51.2 0.0 2.0 2 0 0 2 2 2 1 HD domain HDOD PF08668.12 CDK97512.1 - 0.0031 17.0 0.5 0.098 12.1 0.5 2.2 1 1 0 1 1 1 1 HDOD domain Antimicrobial12 PF08107.11 CDK97513.1 - 0.11 12.3 0.0 13 5.7 0.0 2.2 2 0 0 2 2 2 0 Pleurocidin family DUF5061 PF16587.5 CDK97513.1 - 0.15 12.2 0.1 0.18 11.9 0.1 1.4 1 1 0 1 1 1 0 17 kDa common-antigen outer membrane protein LPAM_2 PF13627.6 CDK97513.1 - 4.7 7.2 7.5 9.1 6.3 7.5 1.5 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Aminotran_1_2 PF00155.21 CDK97514.1 - 9.4e-81 271.8 0.0 1.1e-80 271.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CDK97514.1 - 8.9e-06 24.5 0.0 1.4e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CDK97514.1 - 0.00056 19.0 0.0 0.00089 18.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CDK97514.1 - 0.016 14.5 0.2 0.029 13.6 0.2 1.4 1 1 0 1 1 1 0 Beta-eliminating lyase Aminotran_3 PF00202.21 CDK97515.1 - 6.5e-93 311.6 0.0 8e-93 311.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III CBM39 PF15886.5 CDK97516.1 - 0.00091 19.1 0.1 0.00098 19.0 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate binding domain (family 32) Pox_LP_H2 PF03356.15 CDK97516.1 - 0.0091 15.9 0.1 0.01 15.7 0.1 1.1 1 0 0 1 1 1 1 Viral late protein H2 NHL PF01436.21 CDK97517.1 - 8.3e-24 82.4 0.4 0.00018 21.3 0.0 7.0 7 0 0 7 7 7 4 NHL repeat Thioredoxin_8 PF13905.6 CDK97517.1 - 7.2e-09 35.9 0.0 1.3e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CDK97517.1 - 1.2e-08 34.9 0.0 2e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDK97517.1 - 3.4e-05 23.6 0.0 6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Redoxin SGL PF08450.12 CDK97517.1 - 5.4e-05 22.9 0.0 1.2 8.6 0.0 3.4 1 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Thioredoxin PF00085.20 CDK97517.1 - 0.0062 16.5 0.0 0.15 12.1 0.1 2.2 2 0 0 2 2 2 1 Thioredoxin Phytase-like PF13449.6 CDK97517.1 - 0.023 14.6 0.1 14 5.5 0.0 3.1 2 1 1 3 3 3 0 Esterase-like activity of phytase DUF1145 PF06611.12 CDK97517.1 - 0.21 11.6 0.1 0.42 10.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1145) HATPase_c PF02518.26 CDK97518.1 - 2.1e-21 76.5 0.0 4.1e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 CDK97518.1 - 4.5e-15 55.6 0.0 1.2e-14 54.3 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDK97518.1 - 2.9e-12 46.8 0.4 2.9e-12 46.8 0.4 3.0 3 1 0 3 3 3 1 PAS fold PAS_9 PF13426.7 CDK97518.1 - 9.4e-11 41.9 0.0 2.1e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 PAS domain HisKA PF00512.25 CDK97518.1 - 5.7e-08 32.7 0.9 2.1e-06 27.7 0.0 3.3 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 CDK97518.1 - 5.8e-07 29.4 0.0 2.6e-06 27.3 0.0 2.2 1 0 0 1 1 1 1 PAS domain PAS_7 PF12860.7 CDK97518.1 - 9.6e-05 22.5 0.0 0.00055 20.1 0.0 2.4 2 1 0 2 2 2 1 PAS fold PAS_3 PF08447.12 CDK97518.1 - 0.039 14.3 0.0 0.13 12.6 0.0 2.0 1 0 0 1 1 1 0 PAS fold PVL_ORF50 PF07768.11 CDK97518.1 - 0.045 14.1 0.1 0.13 12.6 0.1 1.7 1 0 0 1 1 1 0 PVL ORF-50-like family Usp PF00582.26 CDK97519.1 - 2.7e-21 76.6 5.6 1.2e-11 45.3 2.1 3.0 2 1 0 2 2 2 2 Universal stress protein family LysE PF01810.18 CDK97520.1 - 2.9e-11 43.2 17.5 3.8e-11 42.8 17.5 1.1 1 0 0 1 1 1 1 LysE type translocator ACR_tran PF00873.19 CDK97520.1 - 0.014 13.1 3.4 0.018 12.7 3.4 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family DUF1345 PF07077.11 CDK97520.1 - 0.068 12.9 5.1 0.063 13.0 3.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1345) Oxidored_nitro PF00148.19 CDK97521.1 - 2.3e-109 365.8 0.2 2.6e-109 365.6 0.2 1.0 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase 2-Hacid_dh_C PF02826.19 CDK97521.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Oxidored_nitro PF00148.19 CDK97522.1 - 2.4e-115 385.5 0.0 2.7e-115 385.3 0.0 1.0 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase 3HCDH_RFF PF18321.1 CDK97522.1 - 0.081 13.4 0.0 4.5 7.8 0.0 2.5 2 0 0 2 2 2 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain DHO_dh PF01180.21 CDK97522.1 - 0.15 11.3 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Nitro_FeMo-Co PF02579.17 CDK97523.1 - 1.6e-17 63.6 0.1 2.1e-17 63.2 0.1 1.2 1 0 0 1 1 1 1 Dinitrogenase iron-molybdenum cofactor DUF269 PF03270.13 CDK97524.1 - 8.5e-44 148.5 0.0 9.8e-44 148.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF269 Fer4 PF00037.27 CDK97525.1 - 2.4e-11 42.9 11.7 7.8e-07 28.7 1.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 CDK97525.1 - 1.5e-10 40.7 10.6 4.1e-06 26.6 1.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 CDK97525.1 - 2.2e-08 34.5 9.1 4.2e-08 33.6 9.2 1.4 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDK97525.1 - 6.3e-08 32.3 10.8 0.00037 20.4 1.2 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 CDK97525.1 - 8e-08 32.3 20.5 4e-05 23.7 12.2 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDK97525.1 - 1.8e-07 31.1 11.3 7.4e-07 29.2 11.3 1.8 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK97525.1 - 1e-06 28.7 11.7 3.8e-06 26.9 11.7 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_22 PF17179.4 CDK97525.1 - 1.7e-06 28.8 7.4 0.00038 21.2 0.5 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDK97525.1 - 3e-06 27.7 5.3 0.0058 17.2 0.1 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDK97525.1 - 1.6e-05 25.3 8.5 2.9e-05 24.4 8.5 1.4 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDK97525.1 - 1.6e-05 25.7 8.9 4.5e-05 24.3 8.8 1.7 1 1 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_3 PF12798.7 CDK97525.1 - 0.00027 21.7 17.0 0.027 15.4 4.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CDK97525.1 - 0.00078 19.8 14.7 0.063 13.8 3.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 CDK97525.1 - 0.031 15.0 10.9 0.2 12.4 3.6 2.3 2 1 0 2 2 2 0 4Fe-4S single cluster domain Fer4_18 PF13746.6 CDK97525.1 - 0.26 11.5 12.1 1.6 8.9 2.9 2.1 1 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 CDK97525.1 - 0.27 11.8 11.4 0.45 11.1 1.5 2.3 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I NifQ PF04891.12 CDK97526.1 - 3.8e-57 193.1 0.1 4.6e-57 192.9 0.1 1.1 1 0 0 1 1 1 1 NifQ CIMR PF00878.18 CDK97526.1 - 0.041 13.9 0.0 0.061 13.4 0.0 1.2 1 0 0 1 1 1 0 Cation-independent mannose-6-phosphate receptor repeat Fe-S_biosyn PF01521.20 CDK97527.1 - 3.3e-19 69.1 0.0 3.6e-19 69.0 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis HMGL-like PF00682.19 CDK97528.1 - 2.4e-80 269.9 0.5 3e-80 269.6 0.5 1.1 1 0 0 1 1 1 1 HMGL-like FeoA PF04023.14 CDK97529.1 - 3e-16 59.4 0.1 3.3e-16 59.3 0.1 1.0 1 0 0 1 1 1 1 FeoA domain FeoB_N PF02421.18 CDK97530.1 - 2.8e-66 221.8 0.0 6.6e-66 220.7 0.0 1.6 2 0 0 2 2 2 1 Ferrous iron transport protein B Gate PF07670.14 CDK97530.1 - 1.4e-48 163.8 11.0 1.6e-33 115.3 0.6 2.8 2 0 0 2 2 2 2 Nucleoside recognition FeoB_C PF07664.12 CDK97530.1 - 2.1e-21 75.4 0.3 8.7e-21 73.4 0.3 2.2 1 0 0 1 1 1 1 Ferrous iron transport protein B C terminus MMR_HSR1 PF01926.23 CDK97530.1 - 2.7e-18 66.1 0.0 4.6e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_Cyto PF17910.1 CDK97530.1 - 4.6e-12 46.3 0.0 8.1e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 FeoB cytosolic helical domain SRPRB PF09439.10 CDK97530.1 - 0.0036 16.8 0.0 0.006 16.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 CDK97530.1 - 0.014 15.3 0.0 1.9 8.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 CDK97530.1 - 0.026 14.1 0.0 7.1 6.1 0.0 2.6 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CDK97530.1 - 0.042 13.9 0.0 0.27 11.3 0.0 2.0 2 0 0 2 2 2 0 Dynamin family ATP_bind_1 PF03029.17 CDK97530.1 - 0.043 13.6 0.2 0.87 9.3 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 CDK97530.1 - 0.1 13.1 0.1 0.18 12.3 0.1 1.4 1 0 0 1 1 1 0 ABC transporter Jiraiya PF15038.6 CDK97530.1 - 0.12 11.8 4.8 4.4 6.7 0.6 2.5 2 0 0 2 2 2 0 Jiraiya DUF3267 PF11667.8 CDK97530.1 - 4.2 7.7 15.3 1.4 9.2 1.5 3.3 3 0 0 3 3 3 0 Putative zincin peptidase FeoC PF09012.10 CDK97531.1 - 8.7e-23 80.2 0.1 9.7e-23 80.0 0.1 1.0 1 0 0 1 1 1 1 FeoC like transcriptional regulator Cupin_2 PF07883.11 CDK97532.1 - 2e-10 40.3 0.4 2.9e-10 39.7 0.4 1.3 1 0 0 1 1 1 1 Cupin domain Auxin_BP PF02041.16 CDK97532.1 - 0.005 16.5 0.0 0.006 16.3 0.0 1.2 1 0 0 1 1 1 1 Auxin binding protein MannoseP_isomer PF01050.18 CDK97532.1 - 0.014 15.3 0.0 0.017 15.0 0.0 1.1 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase HAD_2 PF13419.6 CDK97533.1 - 3e-29 102.4 0.0 3.5e-29 102.1 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDK97533.1 - 1.5e-20 74.4 0.0 9.7e-19 68.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDK97533.1 - 5e-08 32.9 0.0 1e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CDK97533.1 - 1.2e-05 25.8 0.2 1.5e-05 25.4 0.2 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NT5C PF06941.12 CDK97533.1 - 0.0092 15.9 0.0 0.5 10.2 0.0 2.6 2 1 1 3 3 3 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) NIF PF03031.18 CDK97533.1 - 0.021 14.6 0.0 0.16 11.7 0.0 1.9 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase FtsX PF02687.21 CDK97534.1 - 0.0047 17.4 3.6 0.038 14.5 1.0 2.0 2 0 0 2 2 2 1 FtsX-like permease family DUF202 PF02656.15 CDK97534.1 - 0.017 15.5 5.5 0.035 14.6 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF3087 PF11286.8 CDK97534.1 - 0.026 14.0 0.3 3.2 7.2 0.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3087) CcmH PF03918.14 CDK97534.1 - 0.031 13.6 1.0 0.093 12.0 0.1 2.0 2 0 0 2 2 2 0 Cytochrome C biogenesis protein Saf_2TM PF18303.1 CDK97534.1 - 0.069 12.7 0.2 0.13 11.8 0.2 1.5 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF4381 PF14316.6 CDK97534.1 - 1.2 9.3 4.0 18 5.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) DUF4131 PF13567.6 CDK97534.1 - 1.4 8.5 7.5 0.51 10.0 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF5316 PF17247.2 CDK97534.1 - 2.9 7.9 8.0 7.2 6.7 0.9 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5316) Col_cuticle_N PF01484.17 CDK97534.1 - 3.3 7.8 5.7 2 8.5 1.4 2.4 1 1 1 2 2 2 0 Nematode cuticle collagen N-terminal domain Phage_holin_3_6 PF07332.11 CDK97534.1 - 5.2 7.1 12.9 44 4.2 9.9 2.4 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Phage_integrase PF00589.22 CDK97535.1 - 2.3e-23 82.9 0.5 3.8e-23 82.1 0.5 1.4 1 0 0 1 1 1 1 Phage integrase family Sigma70_r4_2 PF08281.12 CDK97535.1 - 1.9 8.3 5.7 0.19 11.4 0.6 2.2 2 1 0 2 2 2 0 Sigma-70, region 4 HTH_3 PF01381.22 CDK97536.1 - 9e-16 57.7 0.3 1.1e-15 57.3 0.3 1.1 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CDK97536.1 - 3.8e-13 49.6 0.6 5.2e-13 49.1 0.6 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CDK97536.1 - 9.4e-12 44.8 0.1 1.2e-11 44.4 0.1 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 CDK97536.1 - 8.1e-08 32.6 0.0 9.5e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_25 PF13413.6 CDK97536.1 - 0.00033 20.5 1.8 0.00053 19.8 1.8 1.4 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 CDK97536.1 - 0.0018 18.2 0.2 0.002 18.0 0.2 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CDK97537.1 - 3e-16 59.5 0.3 4.5e-16 58.9 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDK97537.1 - 3.9e-06 26.5 0.0 6.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 CDK97537.1 - 0.0076 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 CDK97537.1 - 0.02 15.0 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 CDK97537.1 - 0.045 13.4 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.6 CDK97537.1 - 0.076 13.0 0.2 0.68 10.0 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn helix HTH_35 PF13693.6 CDK97537.1 - 0.13 12.3 0.0 1 9.4 0.0 2.0 1 1 1 2 2 2 0 Winged helix-turn-helix DNA-binding TnpB_IS66 PF05717.13 CDK97538.1 - 9.3e-38 128.2 0.0 1e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein DDE_Tnp_IS66 PF03050.14 CDK97539.1 - 3.3e-89 299.1 0.9 4.9e-89 298.6 0.0 1.7 2 0 0 2 2 2 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK97539.1 - 2.9e-18 65.8 0.0 1e-17 64.0 0.0 2.0 1 0 0 1 1 1 1 IS66 C-terminal element LZ_Tnp_IS66 PF13007.7 CDK97539.1 - 6.5e-17 62.1 4.4 6.5e-17 62.1 4.4 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDK97539.1 - 1.5e-15 57.3 4.6 2.9e-15 56.4 4.6 1.5 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDK97539.1 - 0.092 12.6 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 HTH_Tnp_IS630 PF01710.16 CDK97541.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK97541.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK97541.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK97541.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK97541.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK97541.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDK97542.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK97542.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain DDE_Tnp_1 PF01609.21 CDK97544.1 - 9.6e-12 45.0 0.2 1.3e-11 44.6 0.2 1.4 1 1 0 1 1 1 1 Transposase DDE domain DDE_Tnp_4 PF13359.6 CDK97544.1 - 0.01 15.5 0.1 0.017 14.8 0.1 1.4 1 1 0 1 1 1 0 DDE superfamily endonuclease DUF3818 PF12825.7 CDK97545.1 - 0.0064 15.5 0.3 0.047 12.7 0.2 1.9 1 1 1 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) Nucleoporin_C PF03177.14 CDK97545.1 - 0.025 13.3 0.1 0.03 13.1 0.1 1.1 1 0 0 1 1 1 0 Non-repetitive/WGA-negative nucleoporin C-terminal DASH_Dam1 PF08653.10 CDK97545.1 - 0.19 11.6 2.6 1.2 9.0 0.1 3.0 3 1 1 4 4 4 0 DASH complex subunit Dam1 DUF772 PF05598.11 CDK97547.1 - 1e-20 73.5 0.0 2.3e-20 72.4 0.0 1.6 1 0 0 1 1 1 1 Transposase domain (DUF772) DDE_Tnp_1 PF01609.21 CDK97547.1 - 6.6e-13 48.8 1.5 1.2e-12 47.9 1.5 1.4 1 1 0 1 1 1 1 Transposase DDE domain DDE_Tnp_4 PF13359.6 CDK97547.1 - 0.02 14.6 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_Tnp_1_6 PF13751.6 CDK97547.1 - 0.2 11.9 0.1 0.37 11.0 0.1 1.4 1 0 0 1 1 1 0 Transposase DDE domain dUTPase PF00692.19 CDK97551.1 - 1.3e-05 24.9 0.0 2.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 dUTPase Flagellar_put PF12611.8 CDK97551.1 - 0.014 15.2 0.3 0.023 14.4 0.3 1.3 1 0 0 1 1 1 0 Putative flagellar EPSP_synthase PF00275.20 CDK97552.1 - 5.1e-94 315.3 5.5 6.4e-94 315.0 5.5 1.1 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FGE-sulfatase PF03781.16 CDK97553.1 - 8.4e-50 169.8 4.5 1.4e-49 169.1 4.5 1.3 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 SBP_bac_5 PF00496.22 CDK97555.1 - 6e-60 203.2 0.0 7.6e-60 202.9 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle BPD_transp_1 PF00528.22 CDK97556.1 - 3.4e-42 144.3 8.8 3.4e-42 144.3 8.8 1.8 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3624 PF12292.8 CDK97556.1 - 0.22 11.9 1.5 1.7 9.1 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3624) DUF3021 PF11457.8 CDK97556.1 - 0.29 11.4 2.3 1.8 8.9 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) BPD_transp_1 PF00528.22 CDK97557.1 - 2.7e-31 108.7 11.5 2.7e-31 108.7 11.5 2.0 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 CDK97557.1 - 0.011 15.6 1.3 0.011 15.6 1.3 3.3 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C Oxidored_nitro PF00148.19 CDK97558.1 - 9.9e-117 390.0 0.0 1.2e-116 389.8 0.0 1.0 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase DUF3364 PF11844.8 CDK97558.1 - 1e-24 86.5 1.3 1.8e-24 85.7 1.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3364) Oxidored_nitro PF00148.19 CDK97559.1 - 8.4e-114 380.4 0.0 1e-113 380.1 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase Fer4_NifH PF00142.18 CDK97560.1 - 6.6e-132 438.9 1.4 7.5e-132 438.8 1.4 1.0 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_31 PF13614.6 CDK97560.1 - 8.9e-09 35.5 0.4 1.9e-08 34.4 0.2 1.6 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 CDK97560.1 - 2.2e-08 34.2 0.0 4.3e-08 33.3 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CDK97560.1 - 3.4e-07 29.8 0.0 6.5e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Anion-transporting ATPase ParA PF10609.9 CDK97560.1 - 1.3e-05 24.8 0.2 0.0012 18.4 0.1 2.2 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 CDK97560.1 - 0.0036 16.8 0.1 0.39 10.2 0.0 2.2 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ AAA_24 PF13479.6 CDK97560.1 - 0.039 13.7 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain MipZ PF09140.11 CDK97560.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 ATPase MipZ DUF1896 PF08989.10 CDK97560.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1896) DRAT PF07357.11 CDK97561.1 - 2e-110 368.0 0.0 2.3e-110 367.8 0.0 1.0 1 0 0 1 1 1 1 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) ADP_ribosyl_GH PF03747.14 CDK97562.1 - 7.1e-61 206.5 5.7 7.4e-60 203.1 5.7 1.9 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase Romo1 PF10247.9 CDK97562.1 - 0.31 11.4 2.9 1.7 9.0 0.1 2.5 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 ArsC PF03960.15 CDK97563.1 - 0.0013 18.7 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 ArsC family Heme_oxygenase PF01126.20 CDK97564.1 - 2.6e-09 37.1 0.1 3.2e-08 33.6 0.1 2.0 1 1 0 1 1 1 1 Heme oxygenase PHY PF00360.20 CDK97565.1 - 5.5e-37 126.8 0.0 9.1e-37 126.1 0.0 1.3 1 0 0 1 1 1 1 Phytochrome region HATPase_c PF02518.26 CDK97565.1 - 9.4e-27 93.7 0.0 1.8e-26 92.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK97565.1 - 8.4e-19 67.4 0.1 2.8e-18 65.7 0.1 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 CDK97565.1 - 1e-08 35.8 0.0 6.8e-08 33.2 0.0 2.4 2 0 0 2 2 2 1 GAF domain PAS_2 PF08446.11 CDK97565.1 - 6.1e-08 33.3 0.0 3.1e-07 31.0 0.0 2.3 3 0 0 3 3 3 1 PAS fold HATPase_c_2 PF13581.6 CDK97565.1 - 0.0022 17.9 0.0 0.006 16.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 CDK97565.1 - 0.049 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 GHKL domain HATPase_c_3 PF13589.6 CDK97565.1 - 0.094 12.5 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Fer2 PF00111.27 CDK97566.1 - 1.9e-12 47.0 0.4 4.7e-12 45.7 0.4 1.6 1 1 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF1150 PF06620.11 CDK97566.1 - 0.076 13.2 0.0 0.22 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1150) SIR2_2 PF13289.6 CDK97567.1 - 2.3e-20 73.2 0.0 3.1e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 SIR2-like domain Pep1_7 PF17232.2 CDK97567.1 - 0.24 11.9 0.0 0.37 11.3 0.0 1.3 1 0 0 1 1 1 0 Elicitor peptide 1-7 NifT PF06988.11 CDK97568.1 - 3.5e-26 90.8 0.3 4e-26 90.6 0.3 1.0 1 0 0 1 1 1 1 NifT/FixU protein NifZ PF04319.13 CDK97569.1 - 2.4e-28 97.7 0.0 2.8e-28 97.5 0.0 1.0 1 0 0 1 1 1 1 NifZ domain Fer4 PF00037.27 CDK97570.1 - 8.6e-06 25.4 2.2 8.6e-06 25.4 2.2 3.2 3 1 0 3 3 3 1 4Fe-4S binding domain Fer4_21 PF14697.6 CDK97570.1 - 1.3e-05 25.2 14.3 1.6e-05 24.9 14.3 1.1 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK97570.1 - 2.4e-05 24.4 14.4 3.3e-05 23.9 14.4 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDK97570.1 - 3.7e-05 24.2 12.9 8e-05 23.2 13.0 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK97570.1 - 0.00022 21.1 17.0 0.0025 17.8 2.0 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 CDK97570.1 - 0.00046 20.1 16.8 0.0058 16.7 3.0 2.4 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_9 PF13187.6 CDK97570.1 - 0.0013 18.8 14.9 0.002 18.3 14.9 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDK97570.1 - 0.005 17.7 7.1 0.005 17.7 7.1 2.1 1 1 1 2 2 2 1 4Fe-4S double cluster binding domain Fer4_17 PF13534.6 CDK97570.1 - 0.034 14.7 3.9 0.034 14.7 3.9 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 CDK97570.1 - 0.13 12.8 15.7 0.81 10.4 1.8 2.6 2 1 0 2 2 2 0 4Fe-4S binding domain Fer4_8 PF13183.6 CDK97570.1 - 0.26 11.8 14.6 0.3 11.5 4.1 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDK97570.1 - 0.3 12.1 14.0 0.38 11.8 1.5 2.7 2 1 0 2 2 2 0 4Fe-4S binding domain Radical_SAM PF04055.21 CDK97571.1 - 1.4e-25 90.6 0.0 2.4e-25 89.9 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Nitro_FeMo-Co PF02579.17 CDK97571.1 - 6.9e-20 71.2 0.0 1.7e-19 69.9 0.0 1.7 1 0 0 1 1 1 1 Dinitrogenase iron-molybdenum cofactor Calici_coat PF00915.20 CDK97571.1 - 0.012 14.6 0.0 0.03 13.2 0.0 1.6 2 0 0 2 2 2 0 Calicivirus coat protein Sigma54_activat PF00158.26 CDK97572.1 - 7.1e-73 243.8 0.6 1.3e-72 243.0 0.6 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CDK97572.1 - 1.8e-21 76.7 0.0 4.2e-21 75.5 0.0 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CDK97572.1 - 3.1e-14 52.5 0.2 8.2e-14 51.1 0.2 1.7 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CDK97572.1 - 2.9e-10 40.3 0.1 1.3e-08 34.9 0.1 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) GAF PF01590.26 CDK97572.1 - 3e-09 37.6 0.0 6.3e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 GAF domain Mg_chelatase PF01078.21 CDK97572.1 - 4.2e-07 29.6 0.9 1.1e-05 25.0 0.9 2.2 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 CDK97572.1 - 1.1e-06 29.1 0.2 3e-06 27.7 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) GAF_2 PF13185.6 CDK97572.1 - 6e-06 26.6 0.0 1.3e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 GAF domain AAA_2 PF07724.14 CDK97572.1 - 1.1e-05 25.7 0.0 5.4e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) HTH_28 PF13518.6 CDK97572.1 - 0.023 14.8 0.2 0.086 13.0 0.2 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain GAF_3 PF13492.6 CDK97572.1 - 0.03 14.6 0.0 0.089 13.1 0.0 1.9 1 0 0 1 1 1 0 GAF domain HTH_23 PF13384.6 CDK97572.1 - 0.032 14.0 0.1 0.081 12.7 0.1 1.7 1 0 0 1 1 1 0 Homeodomain-like domain AAA_3 PF07726.11 CDK97572.1 - 0.036 13.9 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 CDK97572.1 - 0.11 11.7 0.2 0.18 11.0 0.2 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_16 PF13191.6 CDK97572.1 - 0.13 12.6 0.1 0.62 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain TIP39 PF14980.6 CDK97572.1 - 0.15 12.0 0.1 0.32 10.9 0.1 1.5 1 0 0 1 1 1 0 TIP39 peptide AAA_7 PF12775.7 CDK97572.1 - 0.16 11.5 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NYD-SP28_assoc PF14775.6 CDK97572.1 - 0.23 11.6 0.2 0.74 10.0 0.2 1.8 1 0 0 1 1 1 0 Sperm tail C-terminal domain Rubrerythrin PF02915.17 CDK97573.1 - 2e-12 47.7 7.4 3e-12 47.1 7.4 1.3 1 1 0 1 1 1 1 Rubrerythrin Ferritin_2 PF13668.6 CDK97573.1 - 5.9e-07 29.7 5.9 1.8e-05 24.9 0.4 2.1 2 0 0 2 2 2 2 Ferritin-like domain Ferritin PF00210.24 CDK97573.1 - 1.9e-06 27.9 6.4 1.2e-05 25.3 6.1 1.9 1 1 0 1 1 1 1 Ferritin-like domain DUF2383 PF09537.10 CDK97573.1 - 0.0017 18.7 0.2 0.0017 18.7 0.2 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF2383) DUF4439 PF14530.6 CDK97573.1 - 0.011 16.4 2.0 0.39 11.4 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4439) COQ7 PF03232.13 CDK97573.1 - 0.11 12.3 3.8 0.11 12.3 0.2 2.1 2 0 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 V-ATPase_G_2 PF16999.5 CDK97573.1 - 1.1 9.7 10.6 5.6 7.4 2.0 2.4 2 1 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit ETF_QO PF05187.13 CDK97574.1 - 4.7e-07 29.9 1.8 6.4e-07 29.5 1.8 1.4 1 1 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_7 PF12838.7 CDK97574.1 - 0.0087 16.6 4.4 0.019 15.6 4.4 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDK97574.1 - 0.025 14.7 5.4 0.043 14.0 5.4 1.3 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDK97574.1 - 0.029 14.5 3.1 0.029 14.5 3.1 2.1 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_21 PF14697.6 CDK97574.1 - 0.03 14.5 1.2 0.03 14.5 1.2 1.8 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK97574.1 - 0.042 14.0 6.9 0.095 12.8 7.0 1.5 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 CDK97574.1 - 0.14 12.8 3.0 0.14 12.8 3.0 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4 PF00037.27 CDK97574.1 - 0.9 9.5 10.7 0.93 9.4 5.0 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.7 CDK97574.1 - 8.7 6.6 9.4 5.1 7.4 2.9 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain DAO PF01266.24 CDK97575.1 - 4.8e-10 39.5 0.6 0.00063 19.4 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CDK97575.1 - 1.9e-09 37.3 2.4 1.1e-08 34.7 2.4 2.0 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CDK97575.1 - 2e-07 30.5 0.6 0.0071 15.6 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDK97575.1 - 3.1e-06 26.5 1.0 0.013 14.6 0.3 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A HI0933_like PF03486.14 CDK97575.1 - 5.1e-06 25.4 1.0 0.00017 20.5 0.2 2.2 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 CDK97575.1 - 5.3e-06 26.6 0.3 0.00015 21.9 0.2 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CDK97575.1 - 1.1e-05 25.0 0.2 1.7e-05 24.4 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDK97575.1 - 1.7e-05 24.1 4.0 0.00011 21.4 0.5 2.5 1 1 2 3 3 3 1 FAD binding domain Thi4 PF01946.17 CDK97575.1 - 6.2e-05 22.3 0.9 0.00012 21.4 0.1 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 CDK97575.1 - 0.00025 21.5 0.3 1.1 9.9 0.1 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDK97575.1 - 0.00027 20.3 1.3 0.0011 18.3 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 CDK97575.1 - 0.0011 17.6 0.0 0.053 12.0 0.0 2.1 2 0 0 2 2 2 1 GDP dissociation inhibitor Lycopene_cycl PF05834.12 CDK97575.1 - 0.046 12.8 2.1 0.21 10.6 2.1 1.9 1 1 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.14 CDK97575.1 - 0.39 9.5 1.5 4.2 6.1 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase ETF PF01012.21 CDK97576.1 - 2.2e-41 141.7 0.1 3.9e-41 140.9 0.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 CDK97576.1 - 3.3e-35 120.0 4.4 3.7e-35 119.8 0.3 3.1 4 1 0 4 4 4 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.21 CDK97577.1 - 3.1e-47 160.8 0.1 3.1e-47 160.8 0.1 1.6 2 0 0 2 2 2 1 Electron transfer flavoprotein domain LDB19 PF13002.7 CDK97577.1 - 0.037 13.7 0.4 0.092 12.4 0.1 1.8 2 0 0 2 2 2 0 Arrestin_N terminal like NifW PF03206.14 CDK97578.1 - 1.1e-31 109.2 0.0 1.2e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 Nitrogen fixation protein NifW P-II PF00543.22 CDK97579.1 - 4.8e-41 139.5 2.5 5.4e-41 139.3 2.5 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF3240 PF11582.8 CDK97579.1 - 0.0081 16.3 0.1 0.0098 16.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3240) Cdc6_C PF09079.11 CDK97579.1 - 0.01 15.8 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain DUF2007 PF09413.10 CDK97579.1 - 0.08 13.1 0.5 0.37 11.0 0.5 2.0 1 1 0 1 1 1 0 Putative prokaryotic signal transducing protein CdAMP_rec PF06153.11 CDK97579.1 - 0.14 12.4 1.2 1.4 9.2 1.2 2.2 1 1 0 1 1 1 0 Cyclic-di-AMP receptor Ammonium_transp PF00909.21 CDK97580.1 - 8.9e-122 406.6 40.8 1.2e-121 406.2 40.8 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family RACo_linker PF17650.1 CDK97582.1 - 0.0029 17.4 0.7 0.0029 17.4 0.7 1.0 1 0 0 1 1 1 1 RACo linker region IL4 PF00727.18 CDK97582.1 - 0.06 13.6 0.1 0.061 13.6 0.1 1.1 1 0 0 1 1 1 0 Interleukin 4 Pkinase PF00069.25 CDK97582.1 - 0.17 11.2 0.1 0.17 11.2 0.1 1.0 1 0 0 1 1 1 0 Protein kinase domain HATPase_c PF02518.26 CDK97585.1 - 2.4e-20 73.1 0.0 4.4e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 CDK97585.1 - 5.9e-11 42.6 1.6 5.9e-11 42.6 1.6 2.0 2 0 0 2 2 2 1 HAMP domain HisKA PF00512.25 CDK97585.1 - 3.4e-10 39.8 1.8 4.4e-08 33.0 1.1 2.9 1 1 1 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CDK97585.1 - 0.0024 17.7 0.0 0.004 17.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CDK97585.1 - 0.004 17.1 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain MHYT PF03707.16 CDK97585.1 - 4.8 7.4 12.8 6.4 7.0 2.2 2.8 2 0 0 2 2 2 0 Bacterial signalling protein N terminal repeat Response_reg PF00072.24 CDK97586.1 - 2.4e-32 111.4 0.1 3.5e-32 110.9 0.1 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK97586.1 - 1.3e-23 82.8 0.0 3e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Glutaredoxin PF00462.24 CDK97586.1 - 0.13 12.5 0.0 12 6.1 0.0 2.4 2 0 0 2 2 2 0 Glutaredoxin EKR PF10371.9 CDK97587.1 - 0.0011 18.8 0.0 0.0019 18.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function Lipase_GDSL_2 PF13472.6 CDK97588.1 - 2.4e-16 60.6 0.7 2.4e-15 57.4 0.7 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CDK97588.1 - 0.025 14.6 0.0 0.13 12.2 0.0 2.1 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase HisG PF01634.18 CDK97589.1 - 3.4e-44 150.6 0.0 4.2e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 ATP phosphoribosyltransferase Histidinol_dh PF00815.20 CDK97590.1 - 2.7e-169 563.5 1.0 3.1e-169 563.3 1.0 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase UPF0262 PF06793.12 CDK97591.1 - 2.6e-72 241.9 0.1 3e-72 241.8 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0262) LMWPc PF01451.21 CDK97592.1 - 1.8e-17 64.0 0.0 2.2e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase eIF-1a PF01176.19 CDK97593.1 - 8.1e-28 96.0 0.0 9e-28 95.9 0.0 1.0 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 RsgA_N PF16745.5 CDK97593.1 - 0.00088 19.0 0.0 0.001 18.8 0.0 1.3 1 0 0 1 1 1 1 RsgA N-terminal domain S1 PF00575.23 CDK97593.1 - 0.018 15.4 0.0 0.022 15.1 0.0 1.2 1 0 0 1 1 1 0 S1 RNA binding domain RNase_II_C_S1 PF18614.1 CDK97593.1 - 0.052 13.5 0.0 0.09 12.7 0.0 1.5 1 0 0 1 1 1 0 RNase II-type exonuclease C-terminal S1 domain Maf PF02545.14 CDK97594.1 - 2.8e-47 160.7 0.0 3.1e-47 160.5 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein RNase_E_G PF10150.9 CDK97595.1 - 7.7e-49 166.5 0.0 1e-48 166.1 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease E/G family YacG PF03884.14 CDK97596.1 - 3.9e-11 42.5 3.1 6.7e-11 41.7 3.1 1.4 1 1 0 1 1 1 1 DNA gyrase inhibitor YacG C1_2 PF03107.16 CDK97596.1 - 0.0015 18.8 0.6 0.002 18.4 0.6 1.2 1 0 0 1 1 1 1 C1 domain AzlC PF03591.14 CDK97597.1 - 2.7e-38 131.5 11.8 2.7e-38 131.5 11.8 2.1 2 0 0 2 2 2 1 AzlC protein AzlD PF05437.12 CDK97598.1 - 2.3e-15 56.6 9.2 2.7e-15 56.3 9.2 1.1 1 0 0 1 1 1 1 Branched-chain amino acid transport protein (AzlD) Acetyltransf_1 PF00583.25 CDK97599.1 - 1.6e-08 34.7 0.0 2.4e-08 34.2 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDK97599.1 - 2e-07 31.0 0.0 2.9e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDK97599.1 - 3e-07 30.8 0.0 5.2e-07 30.0 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDK97599.1 - 0.0092 16.1 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDK97599.1 - 0.081 13.1 0.0 0.2 11.8 0.0 1.6 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase adh_short_C2 PF13561.6 CDK97600.1 - 4.7e-40 137.6 0.1 6.9e-40 137.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDK97600.1 - 2.8e-36 124.8 0.0 3.5e-36 124.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDK97600.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 KR domain PALP PF00291.25 CDK97600.1 - 0.0058 16.1 0.4 0.0058 16.1 0.4 1.4 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme ApbA PF02558.16 CDK97600.1 - 0.015 14.9 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Eno-Rase_NADH_b PF12242.8 CDK97600.1 - 0.017 14.8 1.7 0.22 11.3 0.5 2.4 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.6 CDK97600.1 - 0.019 14.8 0.1 0.028 14.3 0.1 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Pyr_redox PF00070.27 CDK97600.1 - 0.034 14.7 0.0 0.23 12.0 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDK97600.1 - 0.044 13.0 0.3 0.16 11.2 0.2 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MutL PF13941.6 CDK97600.1 - 0.049 12.2 1.0 0.069 11.7 1.0 1.1 1 0 0 1 1 1 0 MutL protein NAD_binding_8 PF13450.6 CDK97600.1 - 0.085 13.1 0.4 0.33 11.2 0.1 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DFP PF04127.15 CDK97600.1 - 0.15 11.9 1.0 5.1 6.9 0.1 2.3 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein AdoHcyase_NAD PF00670.21 CDK97600.1 - 0.15 12.1 0.6 0.29 11.2 0.6 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.18 CDK97600.1 - 0.16 11.8 0.1 0.27 11.1 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SAM_MT PF04445.13 CDK97600.1 - 0.16 11.4 1.2 0.23 10.9 1.2 1.2 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase Glyco_trans_4_4 PF13579.6 CDK97600.1 - 0.84 10.1 5.6 2.1 8.8 5.3 1.9 1 1 1 2 2 2 0 Glycosyl transferase 4-like domain Bac_DnaA PF00308.18 CDK97601.1 - 2.9e-09 37.1 0.0 6.9e-05 22.8 0.0 2.1 2 0 0 2 2 2 2 Bacterial dnaA protein AAA_22 PF13401.6 CDK97601.1 - 2.1e-05 24.8 0.1 0.058 13.7 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA PF00004.29 CDK97601.1 - 0.0027 18.1 0.0 0.0076 16.7 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CDK97601.1 - 0.012 16.1 0.0 0.019 15.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter ATPase_2 PF01637.18 CDK97601.1 - 0.014 15.4 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 CDK97601.1 - 0.02 15.3 0.1 0.035 14.5 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 CDK97601.1 - 0.039 13.7 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.12 CDK97601.1 - 0.069 13.1 0.1 0.53 10.2 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AFG1_ATPase PF03969.16 CDK97601.1 - 0.093 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 AFG1-like ATPase AAA_14 PF13173.6 CDK97601.1 - 0.094 12.7 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 CDK97601.1 - 0.12 11.7 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Rad17 PF03215.15 CDK97601.1 - 0.16 11.9 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_5 PF07728.14 CDK97601.1 - 0.16 11.9 0.0 0.36 10.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AI-2E_transport PF01594.16 CDK97602.1 - 2.1e-60 204.6 20.0 2.7e-60 204.2 20.0 1.0 1 0 0 1 1 1 1 AI-2E family transporter DUF2066 PF09839.9 CDK97603.1 - 6.2e-37 127.2 0.7 6.2e-37 127.2 0.7 1.4 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2066) DUF3693 PF12472.8 CDK97603.1 - 0.4 10.4 10.1 2.1 8.1 0.1 3.5 4 0 0 4 4 4 0 Phage related protein VirB8 PF04335.13 CDK97603.1 - 0.42 10.4 4.9 3.4 7.4 3.3 2.4 1 1 1 2 2 2 0 VirB8 protein AIRS_C PF02769.22 CDK97604.1 - 1.7e-37 129.0 0.1 2.6e-37 128.3 0.1 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 CDK97604.1 - 3e-15 56.7 1.3 3e-15 56.7 1.3 1.8 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain Formyl_trans_N PF00551.19 CDK97605.1 - 5.8e-58 195.6 0.0 6.7e-58 195.4 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase Glyco_trans_4_4 PF13579.6 CDK97605.1 - 0.037 14.5 1.1 0.77 10.2 0.3 2.3 2 1 0 2 2 2 0 Glycosyl transferase 4-like domain S4 PF01479.25 CDK97605.1 - 0.039 13.7 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 S4 domain Glyco_transf_4 PF13439.6 CDK97605.1 - 0.11 12.5 0.1 1.4 8.9 0.1 2.1 2 0 0 2 2 2 0 Glycosyltransferase Family 4 MCPsignal PF00015.21 CDK97606.1 - 2.7e-32 111.9 29.3 2.7e-32 111.9 29.3 3.3 2 2 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK97606.1 - 1.3e-09 38.3 0.2 1.3e-09 38.3 0.2 5.0 4 2 1 5 5 5 1 HAMP domain 4HB_MCP_1 PF12729.7 CDK97606.1 - 0.00048 19.7 0.0 0.00048 19.7 0.0 4.4 4 1 0 5 5 5 1 Four helix bundle sensory module for signal transduction DUF1664 PF07889.12 CDK97606.1 - 0.0011 19.0 15.8 0.037 14.1 1.0 3.9 3 1 0 3 3 3 2 Protein of unknown function (DUF1664) Enkurin PF13864.6 CDK97606.1 - 0.13 12.7 4.3 2 8.9 0.1 3.2 3 0 0 3 3 3 0 Calmodulin-binding Laminin_II PF06009.12 CDK97606.1 - 0.39 10.7 29.2 1.7 8.7 1.9 5.3 2 2 3 5 5 5 0 Laminin Domain II FlaC_arch PF05377.11 CDK97606.1 - 0.76 10.2 4.9 31 5.1 0.0 4.3 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) Lactamase_B PF00753.27 CDK97607.1 - 3.1e-21 76.3 1.3 1.6e-20 74.0 1.3 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDK97607.1 - 3.8e-07 29.8 0.1 6.4e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CDK97607.1 - 0.00022 21.2 0.1 0.0006 19.7 0.1 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Cys_Met_Meta_PP PF01053.20 CDK97608.1 - 3e-131 437.5 0.0 3.6e-131 437.2 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme CoA_binding_2 PF13380.6 CDK97608.1 - 2.9e-41 140.6 0.4 2.1e-40 137.8 0.2 2.2 2 0 0 2 2 2 1 CoA binding domain DegT_DnrJ_EryC1 PF01041.17 CDK97608.1 - 3.4e-06 26.6 0.1 6.4e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CDK97608.1 - 8.3e-06 25.0 0.0 1.8e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Aminotransferase class-V CoA_binding PF02629.19 CDK97608.1 - 2.4e-05 24.9 0.8 0.00022 21.9 0.0 2.5 3 0 0 3 3 3 1 CoA binding domain Aminotran_1_2 PF00155.21 CDK97608.1 - 4e-05 22.9 0.0 6.5e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CDK97608.1 - 0.00014 21.3 0.3 0.00052 19.4 0.0 2.0 2 1 0 2 2 2 1 Beta-eliminating lyase GDC-P PF02347.16 CDK97608.1 - 0.0033 16.3 0.0 0.0049 15.8 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein ABC_membrane_2 PF06472.15 CDK97609.1 - 1.5e-48 165.6 0.6 1.9e-48 165.2 0.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 SbmA_BacA PF05992.12 CDK97609.1 - 6.8e-21 75.0 0.4 1e-20 74.4 0.4 1.1 1 0 0 1 1 1 1 SbmA/BacA-like family Silic_transp PF03842.13 CDK97609.1 - 0.066 11.5 0.2 0.11 10.8 0.2 1.2 1 0 0 1 1 1 0 Silicon transporter ABC_tran PF00005.27 CDK97609.1 - 0.14 12.7 0.0 0.94 10.0 0.0 2.2 1 1 0 1 1 1 0 ABC transporter ABC_membrane PF00664.23 CDK97609.1 - 0.2 11.3 5.9 0.41 10.2 0.5 2.4 2 1 0 2 2 2 0 ABC transporter transmembrane region TPR_14 PF13428.6 CDK97610.1 - 0.00057 20.5 0.9 0.00057 20.5 0.9 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDK97610.1 - 0.0031 18.1 3.0 0.0031 18.1 3.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDK97610.1 - 0.011 16.1 0.4 0.057 13.8 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDK97610.1 - 0.084 13.4 5.5 0.18 12.3 0.4 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat His_Phos_1 PF00300.22 CDK97611.1 - 5e-13 49.2 0.0 6.1e-13 48.9 0.0 1.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PP_kinase_C_1 PF17941.1 CDK97612.1 - 9e-75 249.8 0.1 2.1e-74 248.6 0.0 1.6 2 0 0 2 2 2 1 Polyphosphate kinase C-terminal domain 1 PP_kinase_C PF13090.6 CDK97612.1 - 1.8e-64 216.4 0.0 1.2e-62 210.4 0.0 2.2 2 0 0 2 2 2 1 Polyphosphate kinase C-terminal domain 2 PP_kinase PF02503.17 CDK97612.1 - 7e-54 182.5 0.3 1.1e-53 181.9 0.3 1.3 1 0 0 1 1 1 1 Polyphosphate kinase middle domain PP_kinase_N PF13089.6 CDK97612.1 - 1.8e-36 124.7 0.0 4e-36 123.6 0.0 1.6 1 0 0 1 1 1 1 Polyphosphate kinase N-terminal domain PLDc_2 PF13091.6 CDK97612.1 - 2.4e-10 40.4 0.0 0.00075 19.4 0.0 3.4 4 1 0 4 4 4 2 PLD-like domain MR_MLE_C PF13378.6 CDK97612.1 - 0.015 14.8 1.0 0.043 13.4 0.3 1.9 2 0 0 2 2 2 0 Enolase C-terminal domain-like Ppx-GppA PF02541.16 CDK97613.1 - 1.6e-41 142.6 0.0 2.3e-41 142.1 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family HHH_5 PF14520.6 CDK97613.1 - 0.09 13.4 0.1 0.28 11.8 0.1 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix domain HATPase_c PF02518.26 CDK97614.1 - 3.9e-23 82.1 0.0 6.2e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK97614.1 - 4.2e-12 45.9 0.3 4.2e-12 45.9 0.3 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain MASE1 PF05231.14 CDK97614.1 - 5.4e-07 29.1 40.0 8.1e-07 28.5 40.0 1.2 1 0 0 1 1 1 1 MASE1 HATPase_c_5 PF14501.6 CDK97614.1 - 0.014 15.3 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 GHKL domain DNA_pol_A_exo1 PF01612.20 CDK97615.1 - 3.4e-36 124.6 0.0 5e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 CDK97615.1 - 4e-20 71.6 1.6 9e-20 70.4 0.8 2.1 2 0 0 2 2 2 1 HRDC domain RXLR PF16810.5 CDK97615.1 - 0.13 12.7 0.0 11 6.4 0.0 2.2 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity T4SS PF07996.11 CDK97616.1 - 0.00038 20.9 1.2 0.00065 20.2 1.2 1.4 1 1 0 1 1 1 1 Type IV secretion system proteins tRNA-synt_2 PF00152.20 CDK97617.1 - 1.4e-90 303.5 0.0 1.7e-90 303.3 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) GAD PF02938.14 CDK97617.1 - 1.2e-16 60.8 0.1 2e-16 60.0 0.1 1.4 1 0 0 1 1 1 1 GAD domain tRNA_anti-codon PF01336.25 CDK97617.1 - 9.2e-16 57.6 0.0 3.2e-15 55.9 0.0 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDK97617.1 - 0.1 12.0 0.0 2.3 7.7 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) MCPsignal PF00015.21 CDK97619.1 - 3.3e-32 111.7 29.3 3.3e-32 111.7 29.3 4.0 2 1 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain 4HB_MCP_1 PF12729.7 CDK97619.1 - 1.8e-16 60.2 0.8 1.8e-16 60.2 0.8 4.0 3 2 0 3 3 3 1 Four helix bundle sensory module for signal transduction Hemerythrin PF01814.23 CDK97619.1 - 1.6e-11 45.0 1.8 1.6e-11 45.0 1.8 3.9 3 1 0 4 4 4 1 Hemerythrin HHE cation binding domain HAMP PF00672.25 CDK97619.1 - 2.5e-10 40.6 0.8 3.7e-09 36.8 0.0 3.6 3 1 1 4 4 4 1 HAMP domain DUF1664 PF07889.12 CDK97619.1 - 0.03 14.3 27.6 0.033 14.2 2.1 5.1 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) zf-C4H2 PF10146.9 CDK97619.1 - 0.25 11.6 9.5 1.1 9.5 3.8 2.8 1 1 1 2 2 2 0 Zinc finger-containing protein TACC_C PF05010.14 CDK97619.1 - 0.64 9.8 13.5 0.21 11.4 0.8 3.0 2 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Dor1 PF04124.12 CDK97619.1 - 1.7 7.3 7.4 0.31 9.7 1.5 2.6 2 1 0 2 2 2 0 Dor1-like family Spc7 PF08317.11 CDK97619.1 - 3 6.6 15.6 1.4 7.7 4.9 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein AIP3 PF03915.13 CDK97619.1 - 3.4 6.7 21.9 0.081 12.0 8.1 2.4 1 1 1 2 2 2 0 Actin interacting protein 3 CDC37_N PF03234.14 CDK97619.1 - 6.8 7.6 12.0 0.56 11.1 4.6 2.9 2 1 0 2 2 2 0 Cdc37 N terminal kinase binding SNARE PF05739.19 CDK97619.1 - 6.9 6.8 7.3 3.8 7.6 0.9 3.5 3 1 0 3 3 3 0 SNARE domain HMGL-like PF00682.19 CDK97620.1 - 5.2e-60 203.2 0.1 5.9e-60 203.1 0.1 1.0 1 0 0 1 1 1 1 HMGL-like CPSase_L_D2 PF02786.17 CDK97621.1 - 5.6e-77 258.0 0.1 1.2e-76 256.9 0.0 1.6 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CDK97621.1 - 2.1e-47 160.2 0.9 4e-47 159.3 0.3 1.9 2 0 0 2 2 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDK97621.1 - 4.6e-38 129.6 0.0 9.3e-38 128.6 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CDK97621.1 - 1.1e-18 66.8 3.4 2.6e-18 65.6 3.0 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme ATP-grasp PF02222.22 CDK97621.1 - 4.3e-10 39.4 0.1 8.7e-10 38.4 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CDK97621.1 - 1.1e-09 38.1 0.0 6.6e-09 35.6 0.0 2.0 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 CDK97621.1 - 2e-08 33.9 2.0 0.0002 21.1 0.3 2.8 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 CDK97621.1 - 4.2e-07 30.6 2.5 0.0089 16.7 0.1 3.4 3 0 0 3 3 3 2 HlyD family secretion protein ATP-grasp_3 PF02655.14 CDK97621.1 - 3.6e-05 23.9 0.0 7.8e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 CDK97621.1 - 0.00014 21.7 0.1 0.00036 20.4 0.0 1.8 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RnfC_N PF13375.6 CDK97621.1 - 0.00038 20.4 0.8 0.0011 18.8 0.4 2.0 2 0 0 2 2 2 1 RnfC Barrel sandwich hybrid domain HlyD_D23 PF16576.5 CDK97621.1 - 0.00056 19.2 1.4 0.099 11.8 0.3 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion RimK PF08443.11 CDK97621.1 - 0.003 17.2 0.0 0.048 13.3 0.0 2.2 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 CDK97621.1 - 0.015 14.7 0.0 0.031 13.7 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain GCV_H PF01597.19 CDK97621.1 - 0.016 15.1 0.3 0.037 13.9 0.3 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein NQRA PF05896.11 CDK97621.1 - 0.023 14.1 0.3 0.045 13.2 0.3 1.4 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) ATPgrasp_N PF18130.1 CDK97621.1 - 0.03 14.9 0.8 2.1 9.0 0.1 3.1 3 0 0 3 3 3 0 ATP-grasp N-terminal domain PTS_EIIA_1 PF00358.20 CDK97621.1 - 0.079 12.7 1.5 1.6 8.5 0.3 3.1 3 1 2 5 5 5 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 DUF2118 PF09891.9 CDK97621.1 - 0.16 11.9 0.5 0.36 10.8 0.5 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) ECH_1 PF00378.20 CDK97622.1 - 6.7e-56 189.4 0.1 8.1e-56 189.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDK97622.1 - 7.6e-29 101.2 0.3 2.5e-28 99.6 0.3 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 CDK97622.1 - 0.15 12.0 0.4 22 5.0 0.0 2.4 2 0 0 2 2 2 0 Peptidase family S49 Carboxyl_trans PF01039.22 CDK97623.1 - 1.9e-150 501.8 0.1 2.3e-150 501.5 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 CDK97623.1 - 0.025 14.1 0.2 0.89 9.0 0.0 2.3 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) Acyl-CoA_dh_1 PF00441.24 CDK97624.1 - 4.3e-40 137.4 3.0 8.5e-40 136.4 3.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CDK97624.1 - 5.3e-40 136.6 0.1 1.3e-39 135.3 0.1 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CDK97624.1 - 8.8e-27 93.2 0.1 1.8e-26 92.1 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CDK97624.1 - 4.6e-11 43.1 0.3 4.6e-11 43.1 0.3 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 CDK97624.1 - 0.2 12.2 0.0 0.34 11.5 0.0 1.5 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal DctP PF03480.13 CDK97625.1 - 6.7e-46 156.9 0.0 9e-46 156.5 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein, family 7 Guanylate_cyc PF00211.20 CDK97626.1 - 7.7e-29 100.6 0.0 2e-28 99.3 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 CDK97626.1 - 5.4e-22 78.8 0.0 2.4e-21 76.7 0.0 1.9 1 1 0 1 1 1 1 Cache domain Cache_3-Cache_2 PF17201.4 CDK97626.1 - 2.8e-05 23.5 0.0 6.1e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain HAMP PF00672.25 CDK97626.1 - 3e-05 24.3 0.1 0.00026 21.3 0.1 2.6 2 0 0 2 2 2 1 HAMP domain TPR_16 PF13432.6 CDK97626.1 - 0.00083 19.9 2.9 0.0025 18.4 2.9 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 CDK97626.1 - 0.0084 15.8 4.5 0.012 15.2 0.5 2.8 3 0 0 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) dCache_2 PF08269.11 CDK97626.1 - 0.099 11.8 0.0 0.23 10.6 0.0 1.6 1 0 0 1 1 1 0 Cache domain TetR_C_24 PF17932.1 CDK97627.1 - 2.1e-34 118.2 0.0 3.5e-34 117.5 0.0 1.4 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 CDK97627.1 - 4.7e-12 45.5 0.0 1e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_7 PF14246.6 CDK97627.1 - 0.0012 18.9 0.0 0.0027 17.7 0.0 1.6 1 0 0 1 1 1 1 AefR-like transcriptional repressor, C-terminal domain NleF_casp_inhib PF16809.5 CDK97627.1 - 0.0069 16.3 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 NleF caspase inhibitor TetR_C_5 PF08360.11 CDK97627.1 - 0.025 14.8 0.0 0.041 14.1 0.0 1.3 1 0 0 1 1 1 0 QacR-like protein, C-terminal region TetR_C_27 PF17935.1 CDK97627.1 - 0.025 14.6 0.0 0.085 12.9 0.0 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 CDK97627.1 - 0.033 14.3 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase TetR_C_6 PF13977.6 CDK97627.1 - 0.04 14.1 0.2 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 BetI-type transcriptional repressor, C-terminal Rho_N PF07498.12 CDK97627.1 - 0.078 12.9 0.0 0.33 10.9 0.0 2.1 1 1 0 1 1 1 0 Rho termination factor, N-terminal domain GGDEF PF00990.21 CDK97628.1 - 1.9e-47 161.0 0.0 2.4e-47 160.7 0.0 1.1 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GGDEF_2 PF17853.1 CDK97628.1 - 0.0022 18.2 0.2 0.0051 17.1 0.2 1.6 1 0 0 1 1 1 1 GGDEF-like domain UNC-50 PF05216.13 CDK97628.1 - 7.6 6.0 14.1 0.15 11.6 5.6 2.2 2 1 0 2 2 2 0 UNC-50 family Radical_SAM_N PF08497.10 CDK97629.1 - 5e-144 479.0 0.0 6.8e-144 478.6 0.0 1.2 1 0 0 1 1 1 1 Radical SAM N-terminal DUF3362 PF11842.8 CDK97629.1 - 2.9e-41 141.3 0.0 5.3e-41 140.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3362) Radical_SAM PF04055.21 CDK97629.1 - 9.8e-19 68.3 0.0 2.5e-18 67.0 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily B12-binding PF02310.19 CDK97629.1 - 0.0018 18.3 0.0 0.32 11.0 0.0 2.5 2 0 0 2 2 2 2 B12 binding domain Helitron_like_N PF14214.6 CDK97629.1 - 0.19 11.9 0.0 0.45 10.7 0.0 1.5 1 0 0 1 1 1 0 Helitron helicase-like domain at N-terminus OMP_b-brl PF13505.6 CDK97630.1 - 4.1e-28 98.7 11.2 5.6e-28 98.3 11.2 1.2 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CDK97630.1 - 6.4e-06 26.0 4.8 0.23 11.2 2.4 3.1 1 1 1 2 2 2 2 OmpA-like transmembrane domain KdgM PF06178.13 CDK97630.1 - 0.044 13.4 0.2 0.45 10.1 0.0 2.1 2 0 0 2 2 2 0 Oligogalacturonate-specific porin protein (KdgM) BRX_assoc PF16627.5 CDK97630.1 - 0.18 12.0 1.6 0.43 10.8 1.6 1.6 1 0 0 1 1 1 0 Unstructured region between BRX_N and BRX domain LysR_substrate PF03466.20 CDK97631.1 - 8.1e-35 120.1 0.8 1.1e-34 119.7 0.8 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDK97631.1 - 1.9e-17 63.0 0.1 6e-17 61.3 0.1 1.9 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_28 PF13518.6 CDK97631.1 - 2.8e-08 33.8 0.1 5.9e-08 32.7 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDK97631.1 - 3.6e-06 26.6 0.2 1.1e-05 25.1 0.2 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 CDK97631.1 - 1.1e-05 25.3 0.1 3e-05 24.0 0.1 1.8 1 0 0 1 1 1 1 Winged helix-turn helix HTH_30 PF13556.6 CDK97631.1 - 2.6e-05 23.9 0.3 8.1e-05 22.3 0.3 1.9 1 1 0 1 1 1 1 PucR C-terminal helix-turn-helix domain MarR_2 PF12802.7 CDK97631.1 - 0.00058 19.7 0.1 0.0015 18.4 0.1 1.7 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 CDK97631.1 - 0.0013 18.2 0.0 0.0028 17.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_8 PF02954.19 CDK97631.1 - 0.0049 16.6 0.2 0.0095 15.7 0.2 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family HTH_AsnC-type PF13404.6 CDK97631.1 - 0.018 14.8 0.1 0.045 13.6 0.1 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_10 PF04967.12 CDK97631.1 - 0.019 14.8 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain HTH_Tnp_ISL3 PF13542.6 CDK97631.1 - 0.023 14.1 0.0 0.073 12.5 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 DUF746 PF05344.11 CDK97631.1 - 0.043 13.7 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) HTH_IclR PF09339.10 CDK97631.1 - 0.069 13.0 0.0 0.27 11.0 0.0 2.0 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_38 PF13936.6 CDK97631.1 - 0.091 12.5 2.5 0.47 10.2 0.9 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain Peripla_BP_6 PF13458.6 CDK97632.1 - 6.6e-83 279.2 9.7 8.7e-83 278.8 9.7 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Peripla_BP_5 PF13433.6 CDK97632.1 - 1.9e-17 63.3 0.0 3.8e-17 62.3 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding protein domain ANF_receptor PF01094.28 CDK97632.1 - 6.2e-09 35.4 0.0 1.9e-08 33.8 0.0 1.7 1 1 0 1 1 1 1 Receptor family ligand binding region Glyoxalase PF00903.25 CDK97633.1 - 5.1e-17 62.3 0.0 6.6e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CDK97633.1 - 5.2e-05 24.0 0.0 9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 CDK97633.1 - 8.7e-05 22.8 0.0 0.00026 21.3 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MarR_2 PF12802.7 CDK97634.1 - 7.5e-15 54.6 0.0 1.6e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 CDK97634.1 - 1.1e-13 51.5 0.3 1.7e-12 47.6 0.0 2.1 2 0 0 2 2 2 1 Winged helix DNA-binding domain MarR PF01047.22 CDK97634.1 - 4e-10 39.5 0.0 7.6e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 MarR family RP-C PF03428.13 CDK97634.1 - 5.2e-07 29.5 0.3 6.8e-07 29.1 0.3 1.3 1 1 0 1 1 1 1 Replication protein C N-terminal domain TrmB PF01978.19 CDK97634.1 - 5.8e-07 29.3 0.0 7.8e-06 25.7 0.0 2.0 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB SMC_ScpB PF04079.16 CDK97634.1 - 0.023 14.3 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB HTH_24 PF13412.6 CDK97634.1 - 0.031 13.8 0.0 0.12 11.9 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 CDK97634.1 - 0.054 13.4 0.0 0.6 10.0 0.0 2.4 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family HemN_C PF06969.16 CDK97634.1 - 0.054 13.6 0.0 0.18 11.9 0.0 1.9 1 1 0 1 1 1 0 HemN C-terminal domain HTH_Crp_2 PF13545.6 CDK97634.1 - 0.072 13.1 0.4 0.38 10.8 0.1 2.2 1 1 0 2 2 2 0 Crp-like helix-turn-helix domain TFIIE_alpha PF02002.17 CDK97634.1 - 0.11 12.3 0.1 0.72 9.7 0.0 2.2 2 1 1 3 3 3 0 TFIIE alpha subunit Rrf2 PF02082.20 CDK97634.1 - 0.11 12.8 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator Penicillinase_R PF03965.16 CDK97634.1 - 0.12 12.8 0.1 0.76 10.1 0.0 2.0 1 1 0 1 1 1 0 Penicillinase repressor Rio2_N PF09202.11 CDK97634.1 - 0.14 12.4 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Rio2, N-terminal HTH_36 PF13730.6 CDK97634.1 - 0.14 12.2 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain TonB_C PF03544.14 CDK97635.1 - 4.1e-14 52.8 0.0 8.1e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Gram-negative bacterial TonB protein C-terminal TonB_2 PF13103.6 CDK97635.1 - 7.9e-11 42.1 0.0 2.7e-10 40.4 0.0 2.0 1 0 0 1 1 1 1 TonB C terminal ExbD PF02472.16 CDK97636.1 - 3.6e-28 98.3 0.2 4.5e-28 98.0 0.2 1.0 1 0 0 1 1 1 1 Biopolymer transport protein ExbD/TolR HTH_34 PF13601.6 CDK97636.1 - 0.064 13.4 0.0 0.11 12.6 0.0 1.4 1 1 0 1 1 1 0 Winged helix DNA-binding domain MIF PF01187.18 CDK97636.1 - 0.11 12.8 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Macrophage migration inhibitory factor (MIF) MotA_ExbB PF01618.16 CDK97637.1 - 2.8e-32 111.2 3.2 2.8e-32 111.2 3.2 1.6 2 0 0 2 2 2 1 MotA/TolQ/ExbB proton channel family LapA_dom PF06305.11 CDK97637.1 - 2.1 8.2 5.7 0.51 10.2 1.3 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF2218 PF09981.9 CDK97638.1 - 7e-34 116.1 0.0 7.8e-34 115.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2218) DUF520 PF04461.13 CDK97638.1 - 0.033 14.3 0.0 0.042 14.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF520) ABC_tran PF00005.27 CDK97639.1 - 1.2e-28 100.3 0.0 1.6e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK97639.1 - 9.1e-12 45.4 0.4 4e-05 23.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK97639.1 - 5e-05 22.8 0.1 0.13 11.6 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDK97639.1 - 0.00024 20.8 0.1 0.00043 20.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDK97639.1 - 0.004 17.4 0.0 0.006 16.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDK97639.1 - 0.004 17.6 2.5 0.019 15.4 2.5 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CDK97639.1 - 0.0047 17.5 0.0 0.0068 16.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDK97639.1 - 0.0058 16.8 0.0 0.018 15.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDK97639.1 - 0.024 14.4 1.7 0.12 12.1 1.7 1.9 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CDK97639.1 - 0.03 14.4 0.1 0.049 13.7 0.1 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRP54 PF00448.22 CDK97639.1 - 0.032 13.9 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 CDK97639.1 - 0.047 13.6 0.1 0.081 12.8 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_27 PF13514.6 CDK97639.1 - 0.049 13.2 0.1 0.084 12.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDK97639.1 - 0.058 13.6 0.1 0.1 12.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CDK97639.1 - 0.061 12.7 0.1 0.096 12.1 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MeaB PF03308.16 CDK97639.1 - 0.066 12.2 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 CDK97639.1 - 0.087 12.7 0.5 0.21 11.5 0.4 1.7 1 1 0 1 1 1 0 NACHT domain ABC_ATPase PF09818.9 CDK97639.1 - 0.11 11.3 0.1 6.9 5.3 0.2 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_14 PF13173.6 CDK97639.1 - 0.12 12.5 0.0 9.8 6.2 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CDK97639.1 - 0.19 12.2 0.0 0.31 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain FecCD PF01032.18 CDK97640.1 - 1.9e-78 263.6 40.1 2.3e-78 263.3 40.1 1.0 1 0 0 1 1 1 1 FecCD transport family Peripla_BP_2 PF01497.18 CDK97641.1 - 2.5e-15 56.7 0.0 3.7e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein TonB_dep_Rec PF00593.24 CDK97642.1 - 3.4e-36 126.1 28.5 3.4e-36 126.1 28.5 1.5 1 1 0 1 1 1 1 TonB dependent receptor Plug PF07715.15 CDK97642.1 - 8.5e-14 52.0 0.2 2.9e-13 50.3 0.1 2.0 2 0 0 2 2 2 1 TonB-dependent Receptor Plug Domain DUF2490 PF10677.9 CDK97642.1 - 0.022 14.7 0.5 0.044 13.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2490) HTH_18 PF12833.7 CDK97643.1 - 7.1e-22 77.5 2.7 7.1e-22 77.5 2.7 1.9 1 1 1 2 2 2 2 Helix-turn-helix domain HTH_AraC PF00165.23 CDK97643.1 - 5e-13 48.8 0.0 6.4e-08 32.5 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_31 PF13560.6 CDK97643.1 - 0.06 13.7 8.8 0.15 12.4 6.3 2.6 2 1 1 3 3 3 0 Helix-turn-helix domain Dimerisation2 PF16864.5 CDK97643.1 - 0.063 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain DUF1513 PF07433.11 CDK97644.1 - 5.4e-102 341.0 0.1 6.4e-102 340.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1513) NHL PF01436.21 CDK97644.1 - 0.066 13.3 2.7 49 4.2 0.0 4.6 5 0 0 5 5 5 0 NHL repeat PD40 PF07676.12 CDK97644.1 - 0.16 11.9 0.5 9.7 6.3 0.0 3.5 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Peptidase_M75 PF09375.10 CDK97645.1 - 1.1e-45 156.3 4.9 1.3e-45 156.1 4.9 1.0 1 0 0 1 1 1 1 Imelysin DUF3151 PF11349.8 CDK97645.1 - 0.0062 16.6 0.0 0.02 15.0 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3151) PaREP1 PF05942.11 CDK97645.1 - 0.0099 15.8 0.6 0.026 14.4 0.6 1.6 1 0 0 1 1 1 1 Archaeal PaREP1/PaREP8 family DHOR PF06537.11 CDK97646.1 - 5.5e-136 454.1 0.0 6.6e-136 453.8 0.0 1.0 1 0 0 1 1 1 1 Di-haem oxidoreductase, putative peroxidase Cytochrom_C PF00034.21 CDK97646.1 - 6e-09 36.9 0.0 3.1e-05 25.0 0.0 2.6 2 0 0 2 2 2 2 Cytochrome c Cytochrome_CBB3 PF13442.6 CDK97646.1 - 7.2e-05 23.0 1.9 0.11 12.8 0.5 3.2 2 1 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III CCP_MauG PF03150.14 CDK97646.1 - 0.0037 17.9 0.0 0.082 13.6 0.0 2.4 2 0 0 2 2 2 1 Di-haem cytochrome c peroxidase Cytochrome_C7 PF14522.6 CDK97646.1 - 0.0075 16.2 0.3 0.86 9.6 0.1 2.3 2 0 0 2 2 2 1 Cytochrome c7 and related cytochrome c Cytochrom_C550 PF14495.6 CDK97646.1 - 0.023 14.4 0.3 0.38 10.5 0.1 2.2 2 0 0 2 2 2 0 Cytochrome c-550 domain HalOD2 PF18547.1 CDK97646.1 - 0.096 12.6 0.7 16 5.5 0.1 2.8 2 0 0 2 2 2 0 Halobacterial output domain 2 Paired_CXXCH_1 PF09699.10 CDK97646.1 - 1.4 8.8 6.7 2.4 8.0 0.4 2.7 3 0 0 3 3 3 0 Doubled CXXCH motif (Paired_CXXCH_1) Peptidase_M75 PF09375.10 CDK97647.1 - 1.6e-94 316.6 1.7 1.9e-94 316.4 1.7 1.0 1 0 0 1 1 1 1 Imelysin FTSW_RODA_SPOVE PF01098.19 CDK97648.1 - 1.8e-100 336.4 27.6 2.5e-100 336.0 27.6 1.0 1 0 0 1 1 1 1 Cell cycle protein Vma12 PF11712.8 CDK97648.1 - 1.2 9.1 3.5 0.37 10.9 0.4 1.7 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Transpeptidase PF00905.22 CDK97649.1 - 7.4e-72 242.1 0.0 9.4e-72 241.8 0.0 1.1 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 CDK97649.1 - 2.5e-37 128.9 0.0 4.3e-37 128.2 0.0 1.3 1 0 0 1 1 1 1 Penicillin-binding Protein dimerisation domain MreD PF04093.12 CDK97650.1 - 5.8e-09 36.2 9.3 1e-08 35.4 9.3 1.5 1 1 0 1 1 1 1 rod shape-determining protein MreD MreC PF04085.14 CDK97651.1 - 3e-30 105.1 0.0 4.5e-30 104.5 0.0 1.3 1 0 0 1 1 1 1 rod shape-determining protein MreC PRKG1_interact PF15898.5 CDK97651.1 - 0.0036 18.2 1.1 0.0059 17.5 0.9 1.5 1 1 0 1 1 1 1 cGMP-dependent protein kinase interacting domain XRCC4 PF06632.12 CDK97651.1 - 0.017 14.0 0.1 0.024 13.5 0.1 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 ZapB PF06005.12 CDK97651.1 - 0.044 14.2 0.7 0.079 13.4 0.7 1.3 1 0 0 1 1 1 0 Cell division protein ZapB DUF5551 PF17705.1 CDK97651.1 - 0.077 12.6 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5551) Cep57_CLD_2 PF14197.6 CDK97651.1 - 0.1 12.7 2.9 0.33 11.1 0.7 2.2 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 MreB_Mbl PF06723.13 CDK97652.1 - 7.9e-153 508.0 7.3 9e-153 507.8 7.3 1.0 1 0 0 1 1 1 1 MreB/Mbl protein Actin PF00022.19 CDK97652.1 - 2.2e-13 49.6 0.0 2.4e-11 42.9 0.0 2.1 2 0 0 2 2 2 2 Actin HSP70 PF00012.20 CDK97652.1 - 5.3e-12 44.7 0.4 9.2e-12 43.9 0.1 1.8 2 1 0 2 2 2 1 Hsp70 protein FtsA PF14450.6 CDK97652.1 - 3.8e-11 43.3 2.3 5.5e-11 42.8 0.2 2.2 2 1 0 2 2 2 1 Cell division protein FtsA PilM_2 PF11104.8 CDK97652.1 - 3.2e-08 33.0 0.0 0.0029 16.7 0.0 3.0 3 0 0 3 3 3 2 Type IV pilus assembly protein PilM; EutA PF06277.11 CDK97652.1 - 0.0013 17.6 0.3 0.0013 17.6 0.3 1.8 3 0 0 3 3 3 1 Ethanolamine utilisation protein EutA U79_P34 PF03064.16 CDK97652.1 - 0.02 14.3 0.1 1.7 7.9 0.1 2.1 2 0 0 2 2 2 0 HSV U79 / HCMV P34 HMGL-like PF00682.19 CDK97653.1 - 3.2e-96 321.9 2.6 3.5e-96 321.8 1.8 1.5 2 0 0 2 2 2 1 HMGL-like LeuA_dimer PF08502.10 CDK97653.1 - 4.3e-38 130.2 0.0 9.6e-38 129.1 0.0 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain TRAPP PF04051.16 CDK97653.1 - 0.11 12.2 0.0 0.71 9.6 0.0 2.1 2 0 0 2 2 2 0 Transport protein particle (TRAPP) component HATPase_c PF02518.26 CDK97654.1 - 6.7e-22 78.1 0.0 1.3e-21 77.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 CDK97654.1 - 2.1e-12 47.1 0.1 1.6e-11 44.4 0.1 2.3 1 1 0 1 1 1 1 PAS fold HisKA PF00512.25 CDK97654.1 - 1.8e-11 43.9 0.1 5e-11 42.5 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 CDK97654.1 - 1.2e-08 35.1 0.1 4.8e-07 30.0 0.1 3.3 2 1 0 2 2 2 1 PAS fold PAS PF00989.25 CDK97654.1 - 4.7e-08 33.0 0.0 9.7e-07 28.8 0.0 2.8 1 1 0 1 1 1 1 PAS fold dCache_1 PF02743.18 CDK97654.1 - 1.6e-07 31.4 0.0 3.1e-06 27.2 0.0 2.3 2 0 0 2 2 2 1 Cache domain HATPase_c_5 PF14501.6 CDK97654.1 - 5.5e-06 26.2 0.0 1.2e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 GHKL domain PAS_9 PF13426.7 CDK97654.1 - 0.00013 22.2 0.0 0.0012 19.0 0.0 2.6 2 1 0 2 2 2 1 PAS domain PAS_8 PF13188.7 CDK97654.1 - 0.033 14.2 0.0 0.11 12.6 0.0 1.9 1 0 0 1 1 1 0 PAS domain MG2 PF01835.19 CDK97654.1 - 0.047 14.2 0.1 3.3 8.2 0.0 3.4 4 0 0 4 4 4 0 MG2 domain HATPase_c_3 PF13589.6 CDK97654.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDK97655.1 - 2e-23 83.0 0.0 3.7e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 CDK97655.1 - 4.3e-15 56.2 0.0 1e-14 54.9 0.0 1.6 2 0 0 2 2 2 1 Cache domain PAS_3 PF08447.12 CDK97655.1 - 1.6e-10 41.1 0.1 1.8e-09 37.8 0.1 2.6 2 0 0 2 2 2 1 PAS fold HisKA PF00512.25 CDK97655.1 - 4.8e-09 36.1 0.0 1.6e-08 34.5 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CDK97655.1 - 1.3e-05 25.1 0.0 2.3e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 GHKL domain PAS_4 PF08448.10 CDK97655.1 - 2.2e-05 24.6 2.0 0.0003 21.0 0.6 3.3 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.7 CDK97655.1 - 0.0001 22.5 0.0 0.0044 17.3 0.0 3.0 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 CDK97655.1 - 0.0027 17.7 0.0 0.012 15.6 0.0 2.2 1 1 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.6 CDK97655.1 - 0.0056 16.5 0.0 0.0099 15.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CDK97655.1 - 0.0068 16.4 0.0 0.044 13.7 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain Tad PF13400.6 CDK97655.1 - 0.14 12.5 4.5 0.22 11.8 0.2 3.1 3 0 0 3 3 3 0 Putative Flp pilus-assembly TadE/G-like DUF4381 PF14316.6 CDK97655.1 - 0.16 12.2 4.9 0.33 11.2 1.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) PAS_11 PF14598.6 CDK97655.1 - 0.16 12.1 0.0 0.47 10.6 0.0 1.7 1 0 0 1 1 1 0 PAS domain Herpes_glycop PF01528.16 CDK97655.1 - 0.29 9.9 0.9 0.51 9.1 0.9 1.4 1 0 0 1 1 1 0 Herpesvirus glycoprotein M IlvN PF07991.12 CDK97656.1 - 6e-72 240.6 0.7 7.8e-72 240.2 0.7 1.1 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 CDK97656.1 - 7e-68 227.4 0.1 9.3e-68 227.0 0.1 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain 2-Hacid_dh_C PF02826.19 CDK97656.1 - 8.7e-06 25.2 0.0 1.4e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CDK97656.1 - 0.00014 22.0 0.2 0.00025 21.3 0.2 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CDK97656.1 - 0.00024 21.6 0.1 0.00041 20.9 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 CDK97656.1 - 0.0003 20.9 0.1 0.00052 20.1 0.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Oxidored_nitro PF00148.19 CDK97656.1 - 0.00068 18.5 0.4 0.0014 17.4 0.2 1.5 2 0 0 2 2 2 1 Nitrogenase component 1 type Oxidoreductase DUF1103 PF06513.11 CDK97656.1 - 0.0052 16.4 0.0 0.0085 15.7 0.0 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) NAD_binding_7 PF13241.6 CDK97656.1 - 0.041 14.3 0.1 0.096 13.1 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 CDK97656.1 - 0.11 12.6 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GFO_IDH_MocA PF01408.22 CDK97656.1 - 0.15 12.9 0.0 0.28 12.0 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold ALS_ss_C PF10369.9 CDK97657.1 - 3.2e-26 91.3 1.8 3.5e-26 91.2 0.3 1.8 2 1 0 2 2 2 1 Small subunit of acetolactate synthase ACT_5 PF13710.6 CDK97657.1 - 4e-11 42.6 0.1 6.9e-11 41.8 0.1 1.4 1 0 0 1 1 1 1 ACT domain ACT PF01842.25 CDK97657.1 - 3.2e-10 39.6 2.2 3.3e-10 39.5 0.3 2.0 2 1 0 2 2 2 1 ACT domain ACT_4 PF13291.6 CDK97657.1 - 0.0017 18.9 0.7 0.0029 18.1 0.7 1.4 1 0 0 1 1 1 1 ACT domain Glycoprotein PF03409.15 CDK97657.1 - 0.046 12.6 0.1 0.059 12.2 0.1 1.1 1 0 0 1 1 1 0 Transmembrane glycoprotein TPP_enzyme_N PF02776.18 CDK97658.1 - 9.6e-58 194.6 0.1 4.3e-57 192.5 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CDK97658.1 - 9.9e-50 168.3 0.2 3.4e-48 163.3 0.2 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CDK97658.1 - 4.8e-46 155.9 0.1 9.5e-46 154.9 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 CDK97658.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg CO_dh PF02552.16 CDK97658.1 - 0.14 11.9 0.1 0.47 10.2 0.0 1.9 2 0 0 2 2 2 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit IPPT PF01715.17 CDK97659.1 - 3.7e-64 216.7 0.0 4.7e-64 216.3 0.0 1.0 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 CDK97659.1 - 4.8e-06 26.1 0.0 9.2e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Isopentenyl transferase AAA_33 PF13671.6 CDK97659.1 - 0.0094 16.1 0.1 0.031 14.5 0.0 1.8 2 1 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 CDK97659.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase Hydin_ADK PF17213.3 CDK97659.1 - 0.04 14.2 0.3 0.083 13.2 0.3 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain TIP49 PF06068.13 CDK97659.1 - 0.079 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_16 PF13191.6 CDK97659.1 - 0.1 13.0 0.3 0.33 11.3 0.3 2.1 1 1 0 1 1 1 0 AAA ATPase domain CobU PF02283.16 CDK97659.1 - 0.17 11.5 0.9 3 7.4 0.0 2.6 3 0 0 3 3 3 0 Cobinamide kinase / cobinamide phosphate guanyltransferase DUF1018 PF06252.12 CDK97659.1 - 0.7 10.9 4.6 6.9 7.7 0.0 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1018) HAD PF12710.7 CDK97660.1 - 1.3e-14 55.1 0.1 2.2e-14 54.3 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDK97660.1 - 1.1e-09 38.9 3.9 1.6e-09 38.4 3.0 1.7 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDK97660.1 - 4e-06 26.8 0.0 2.4e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2283 PF10049.9 CDK97661.1 - 0.095 13.0 0.0 0.36 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2283) PS_Dcarbxylase PF02666.15 CDK97662.1 - 2.1e-37 128.6 0.0 3e-37 128.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase PSDC PF12588.8 CDK97662.1 - 2.3e-34 118.4 0.0 3.6e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 Phophatidylserine decarboxylase Peptidase_M23 PF01551.22 CDK97662.1 - 0.032 14.4 0.8 0.12 12.6 0.1 2.4 3 1 0 3 3 3 0 Peptidase family M23 Peripla_BP_5 PF13433.6 CDK97664.1 - 5.8e-112 374.3 0.0 1.1e-111 373.4 0.0 1.4 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_6 PF13458.6 CDK97664.1 - 3.1e-47 161.9 0.2 3.1e-47 161.9 0.2 3.2 2 1 1 3 3 2 1 Periplasmic binding protein MCPsignal PF00015.21 CDK97664.1 - 3.6e-25 88.7 23.2 3.6e-25 88.7 23.2 2.5 1 1 1 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF948 PF06103.11 CDK97664.1 - 0.00048 20.3 13.0 0.26 11.6 1.0 4.3 3 1 1 4 4 4 3 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 CDK97664.1 - 0.0015 18.5 2.7 2.7 8.1 0.2 3.6 2 2 2 4 4 4 1 Protein of unknown function (DUF1664) HAMP PF00672.25 CDK97664.1 - 0.0016 18.8 0.9 0.0016 18.8 0.9 3.3 4 0 0 4 4 3 1 HAMP domain DAPDH_C PF16654.5 CDK97664.1 - 0.027 14.3 0.2 0.07 13.0 0.2 1.6 1 0 0 1 1 1 0 Diaminopimelic acid dehydrogenase C-terminal domain AAA_13 PF13166.6 CDK97664.1 - 0.047 12.3 0.7 0.087 11.5 0.6 1.5 1 1 0 1 1 1 0 AAA domain TACC_C PF05010.14 CDK97664.1 - 0.3 10.8 3.5 0.47 10.2 0.6 2.2 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Laminin_II PF06009.12 CDK97664.1 - 0.82 9.7 13.1 7.4 6.6 6.3 3.4 2 2 0 2 2 2 0 Laminin Domain II ApoLp-III PF07464.11 CDK97664.1 - 0.98 9.5 13.5 0.49 10.5 2.3 3.5 1 1 3 4 4 4 0 Apolipophorin-III precursor (apoLp-III) Fez1 PF06818.15 CDK97664.1 - 3.2 8.2 4.6 17 5.8 1.4 2.3 2 0 0 2 2 2 0 Fez1 Fer4_18 PF13746.6 CDK97665.1 - 1.4e-38 131.6 6.9 3.7e-38 130.2 6.9 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain FixG_C PF11614.8 CDK97665.1 - 3.3e-29 101.5 0.0 4.8e-29 101.0 0.0 1.2 1 0 0 1 1 1 1 IG-like fold at C-terminal of FixG, putative oxidoreductase Fer4_7 PF12838.7 CDK97665.1 - 3.2e-09 37.2 7.5 5e-05 23.8 3.3 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_5 PF12801.7 CDK97665.1 - 4.1e-08 33.0 4.1 4.1e-08 33.0 4.1 3.6 4 0 0 4 4 3 1 4Fe-4S binding domain Fer4_17 PF13534.6 CDK97665.1 - 1.4e-07 31.9 6.1 0.00028 21.3 1.9 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDK97665.1 - 1.7e-06 28.1 12.5 0.00024 21.2 2.7 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDK97665.1 - 2.4e-06 27.9 5.3 0.012 16.0 2.0 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 CDK97665.1 - 1.9e-05 24.3 23.0 0.0047 16.7 3.7 3.4 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_4 PF12800.7 CDK97665.1 - 0.0001 22.5 19.4 0.03 14.8 2.4 3.3 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_2 PF12797.7 CDK97665.1 - 0.00038 20.4 20.1 0.0082 16.2 2.9 3.3 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_10 PF13237.6 CDK97665.1 - 0.0018 18.3 15.4 0.065 13.4 14.0 2.8 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDK97665.1 - 0.021 15.0 15.9 0.82 9.8 2.4 2.9 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK97665.1 - 0.061 13.4 20.2 0.15 12.2 3.1 3.0 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_16 PF13484.6 CDK97665.1 - 0.075 14.0 17.3 0.14 13.1 5.4 2.7 1 1 3 4 4 3 0 4Fe-4S double cluster binding domain 7TM_GPCR_Srz PF10325.9 CDK97665.1 - 0.099 12.0 0.2 0.19 11.0 0.2 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srz DUF2157 PF09925.9 CDK97665.1 - 0.13 12.1 7.2 7.6 6.3 4.9 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Fer4_15 PF13459.6 CDK97665.1 - 0.21 12.4 7.4 0.72 10.6 0.3 2.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain Acetyltransf_3 PF13302.7 CDK97666.1 - 2.4e-29 102.8 0.0 2.8e-29 102.6 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDK97666.1 - 1.7e-06 28.2 0.0 2.1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 CDK97666.1 - 0.027 14.1 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF188 PF02639.14 CDK97667.1 - 1.2e-48 164.1 0.1 1.3e-48 163.9 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized BCR, YaiI/YqxD family COG1671 PIN_9 PF18477.1 CDK97667.1 - 0.0025 18.1 0.5 0.0072 16.6 0.3 2.0 1 1 1 2 2 2 1 PIN like domain cNMP_binding PF00027.29 CDK97668.1 - 6.8e-13 48.5 0.0 1.3e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 CDK97668.1 - 6.9e-07 29.1 0.3 1.6e-06 28.0 0.3 1.7 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Crp PF00325.20 CDK97668.1 - 0.088 12.5 0.4 0.21 11.3 0.4 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family TPR_2 PF07719.17 CDK97669.1 - 1.3e-10 40.5 0.7 0.00017 21.5 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDK97669.1 - 9.7e-09 35.3 10.6 1.7e-07 31.3 2.8 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDK97669.1 - 1.5e-08 34.1 0.1 0.00062 19.5 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDK97669.1 - 5.5e-06 26.9 9.4 0.00095 19.8 3.4 2.8 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDK97669.1 - 1.9e-05 25.0 0.5 0.088 13.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDK97669.1 - 3.1e-05 23.9 0.0 0.0079 16.3 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDK97669.1 - 7.3e-05 23.3 8.6 0.043 14.6 0.2 3.4 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDK97669.1 - 0.00011 22.3 0.4 0.13 12.7 0.3 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDK97669.1 - 0.00051 20.5 4.6 0.05 14.1 2.4 2.7 1 1 2 3 3 3 2 Tetratricopeptide repeat DUF4126 PF13548.6 CDK97669.1 - 0.0058 16.3 0.0 0.021 14.5 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4126) TPR_15 PF13429.6 CDK97669.1 - 0.0073 15.6 1.8 1.5 8.0 0.0 2.8 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDK97669.1 - 0.075 13.3 8.6 1.6 9.1 5.4 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDK97669.1 - 0.1 12.3 0.0 0.81 9.4 0.0 2.3 2 0 0 2 2 2 0 TPR repeat FGase PF05013.12 CDK97670.1 - 5.3e-39 134.7 0.0 6.8e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 N-formylglutamate amidohydrolase CbiG_N PF11760.8 CDK97670.1 - 0.07 13.1 0.9 0.32 11.0 0.4 2.2 2 1 1 3 3 3 0 Cobalamin synthesis G N-terminal Response_reg PF00072.24 CDK97671.1 - 5.5e-24 84.5 0.0 6.2e-24 84.3 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Response_reg PF00072.24 CDK97672.1 - 4.6e-26 91.2 0.1 5.3e-26 91.0 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain DUF2312 PF10073.9 CDK97673.1 - 1.4e-32 111.2 7.7 1.6e-32 111.0 7.7 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2312) CPSase_L_D3 PF02787.19 CDK97673.1 - 0.0094 16.3 0.6 0.011 16.1 0.6 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain YkyA PF10368.9 CDK97673.1 - 0.021 14.5 3.6 0.026 14.2 3.6 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Fungal_TACC PF12709.7 CDK97673.1 - 0.038 14.4 1.6 4.1 7.9 0.2 2.1 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins AAA_13 PF13166.6 CDK97673.1 - 0.053 12.2 2.0 0.054 12.1 2.0 1.0 1 0 0 1 1 1 0 AAA domain TnsD PF15978.5 CDK97673.1 - 0.054 12.5 0.4 0.061 12.3 0.4 1.0 1 0 0 1 1 1 0 Tn7-like transposition protein D SAM_Exu PF18609.1 CDK97673.1 - 0.089 12.9 1.7 0.34 11.0 1.7 1.8 1 1 0 1 1 1 0 Exuperantia SAM-like domain HATPase_c PF02518.26 CDK97674.1 - 1.5e-18 67.3 0.0 1e-17 64.6 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK97674.1 - 1.3e-10 41.2 0.1 1.3e-10 41.2 0.1 3.3 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 CDK97674.1 - 8e-08 32.5 0.0 3.3e-07 30.5 0.0 2.2 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDK97674.1 - 3.9e-05 23.8 0.0 9.2e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 CDK97674.1 - 0.00012 22.0 0.0 0.00041 20.3 0.0 1.9 1 0 0 1 1 1 1 PAS domain dCache_1 PF02743.18 CDK97674.1 - 0.00016 21.5 0.0 0.00059 19.7 0.0 1.9 2 0 0 2 2 2 1 Cache domain PAS PF00989.25 CDK97674.1 - 0.00099 19.1 0.0 0.0029 17.6 0.0 1.9 1 0 0 1 1 1 1 PAS fold Vir_act_alpha_C PF10400.9 CDK97674.1 - 0.017 15.8 2.3 0.85 10.3 0.2 3.6 4 0 0 4 4 4 0 Virulence activator alpha C-term DUF4993 PF16384.5 CDK97674.1 - 0.23 10.4 0.0 0.36 9.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function HIP1_clath_bdg PF16515.5 CDK97674.1 - 0.79 10.4 8.0 2.2 8.9 1.5 2.7 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FolB PF02152.18 CDK97675.1 - 4.1e-26 91.7 1.4 4.6e-26 91.5 1.4 1.0 1 0 0 1 1 1 1 Dihydroneopterin aldolase HPPK PF01288.20 CDK97676.1 - 2.1e-36 124.8 0.0 2.5e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Response_reg PF00072.24 CDK97677.1 - 1.2e-22 80.1 0.0 1.8e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 CDK97677.1 - 5e-20 70.8 0.7 9.1e-20 70.0 0.7 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDK97677.1 - 2.2e-05 24.0 0.2 3.9e-05 23.3 0.2 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 OKR_DC_1_N PF03709.15 CDK97677.1 - 0.041 14.2 0.0 0.071 13.4 0.0 1.4 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain Sigma70_r4 PF04545.16 CDK97677.1 - 0.044 13.3 0.6 0.081 12.5 0.6 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HATPase_c PF02518.26 CDK97678.1 - 4.4e-20 72.3 0.0 1.9e-19 70.2 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_2 PF13185.6 CDK97678.1 - 2.2e-19 70.1 0.8 6.1e-19 68.7 0.1 2.1 3 0 0 3 3 3 1 GAF domain Response_reg PF00072.24 CDK97678.1 - 7.6e-18 64.7 0.0 2.1e-17 63.3 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CDK97678.1 - 9.4e-11 41.6 0.1 9.4e-11 41.6 0.1 3.2 4 0 0 4 4 3 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 CDK97678.1 - 9.7e-11 42.4 0.0 1.1e-08 35.8 0.0 3.2 4 0 0 4 4 3 1 GAF domain PAS_8 PF13188.7 CDK97678.1 - 5.9e-09 35.8 0.0 1.7e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_9 PF13426.7 CDK97678.1 - 1.5e-08 34.9 0.0 3.6e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CDK97678.1 - 3.5e-08 33.4 0.0 8.1e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 PAS fold GAF_3 PF13492.6 CDK97678.1 - 0.0012 19.2 0.0 0.004 17.5 0.0 2.0 1 1 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 CDK97678.1 - 0.0044 16.8 0.0 0.0079 16.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CDK97678.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 GHKL domain PAS_4 PF08448.10 CDK97678.1 - 0.016 15.5 0.1 0.14 12.4 0.0 2.6 1 1 1 2 2 2 0 PAS fold HATPase_c_2 PF13581.6 CDK97678.1 - 0.017 15.1 0.0 0.05 13.6 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain YbgT_YccB PF08173.11 CDK97678.1 - 0.077 13.1 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 Membrane bound YbgT-like protein Peptidase_M15_2 PF05951.13 CDK97680.1 - 4.1e-53 179.2 0.0 4.9e-53 178.9 0.0 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF882) Peptidase_M15_3 PF08291.11 CDK97680.1 - 5.7e-12 45.7 0.1 8e-12 45.2 0.1 1.2 1 0 0 1 1 1 1 Peptidase M15 YkuD PF03734.14 CDK97681.1 - 2.2e-32 112.5 0.0 3.5e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 L,D-transpeptidase catalytic domain PG_binding_1 PF01471.18 CDK97681.1 - 6.8e-06 26.2 0.0 2.1e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Putative peptidoglycan binding domain PG_binding_3 PF09374.10 CDK97681.1 - 0.021 15.1 0.0 0.055 13.7 0.0 1.7 1 0 0 1 1 1 0 Predicted Peptidoglycan domain Rhodanese PF00581.20 CDK97682.1 - 8.3e-08 32.7 0.0 1.3e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain NIR_SIR PF01077.22 CDK97683.1 - 3.2e-43 147.0 0.0 4.4e-36 123.8 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 CDK97683.1 - 1.7e-32 111.0 0.7 3e-15 55.8 0.0 3.6 3 0 0 3 3 3 2 Nitrite/Sulfite reductase ferredoxin-like half domain GcpE PF04551.14 CDK97683.1 - 0.0021 17.2 0.4 0.011 14.9 0.1 1.9 2 0 0 2 2 2 1 GcpE protein TetR_C_20 PF17925.1 CDK97683.1 - 0.031 14.6 0.5 0.4 11.0 0.4 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain PAPS_reduct PF01507.19 CDK97684.1 - 3e-37 128.3 0.0 3.6e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family PAPS_reduct PF01507.19 CDK97685.1 - 5.9e-46 156.7 0.0 8.8e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family APS_kinase PF01583.20 CDK97686.1 - 4.1e-67 225.0 0.0 7.6e-67 224.1 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase GTP_EFTU PF00009.27 CDK97686.1 - 6.1e-43 146.6 0.0 9.7e-43 146.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDK97686.1 - 3.2e-08 33.6 0.0 2.6e-06 27.5 0.0 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CDK97686.1 - 7.9e-07 29.6 0.2 0.00065 20.1 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 CDK97686.1 - 1.8e-06 28.5 0.0 0.0014 19.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CDK97686.1 - 9e-06 25.9 0.1 0.0017 18.5 0.0 2.9 3 1 0 3 3 2 1 AAA domain GTP_EFTU_D2 PF03144.25 CDK97686.1 - 2.8e-05 24.4 0.5 0.00014 22.2 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 CDK97686.1 - 0.0001 22.3 0.1 1.1 9.2 0.0 3.5 2 1 1 3 3 3 1 RsgA GTPase AAA_29 PF13555.6 CDK97686.1 - 0.0011 18.7 1.1 0.21 11.4 0.3 3.4 4 0 0 4 4 3 1 P-loop containing region of AAA domain ABC_tran PF00005.27 CDK97686.1 - 0.0011 19.4 0.0 0.23 12.0 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 CDK97686.1 - 0.0015 18.8 0.1 0.4 10.9 0.0 2.7 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 CDK97686.1 - 0.0053 16.8 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.19 CDK97686.1 - 0.0081 15.8 0.3 2.3 7.8 0.0 3.3 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain MipZ PF09140.11 CDK97686.1 - 0.012 14.9 0.0 0.13 11.5 0.0 2.4 3 0 0 3 3 3 0 ATPase MipZ MeaB PF03308.16 CDK97686.1 - 0.015 14.3 0.7 0.051 12.5 0.0 2.2 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 CDK97686.1 - 0.018 15.5 0.0 0.63 10.5 0.0 2.5 2 0 0 2 2 2 0 RNA helicase NTPase_1 PF03266.15 CDK97686.1 - 0.018 14.9 0.0 0.47 10.3 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_28 PF13521.6 CDK97686.1 - 0.027 14.7 0.0 6.8 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 CDK97686.1 - 0.044 14.0 0.1 1.6 9.0 0.0 2.7 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 CDK97686.1 - 0.045 13.3 0.0 0.18 11.4 0.0 2.1 3 0 0 3 3 1 0 AAA domain ParA PF10609.9 CDK97686.1 - 0.05 13.1 0.0 0.21 11.0 0.0 1.9 3 0 0 3 3 3 0 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 CDK97686.1 - 0.057 13.0 0.0 1.2 8.7 0.0 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Dynamin_N PF00350.23 CDK97686.1 - 0.077 13.0 0.3 0.28 11.2 0.0 2.1 3 0 0 3 3 2 0 Dynamin family MobB PF03205.14 CDK97686.1 - 0.08 12.8 0.1 4.7 7.1 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B G-alpha PF00503.20 CDK97686.1 - 0.086 12.0 0.0 1 8.5 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit Zeta_toxin PF06414.12 CDK97686.1 - 0.087 12.1 0.0 0.25 10.6 0.0 1.7 2 0 0 2 2 1 0 Zeta toxin AAA_5 PF07728.14 CDK97686.1 - 0.096 12.7 0.1 0.64 10.0 0.0 2.3 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) FeoB_N PF02421.18 CDK97686.1 - 0.098 12.2 0.1 4.2 6.9 0.0 2.9 2 1 0 2 2 2 0 Ferrous iron transport protein B SRPRB PF09439.10 CDK97686.1 - 0.11 11.9 0.1 4.8 6.6 0.0 2.6 3 0 0 3 3 2 0 Signal recognition particle receptor beta subunit GTP_EFTU_D3 PF03143.17 CDK97686.1 - 0.12 12.6 0.0 0.57 10.5 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu C-terminal domain KTI12 PF08433.10 CDK97686.1 - 0.15 11.5 0.0 0.35 10.3 0.0 1.5 2 0 0 2 2 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 CDK97686.1 - 0.15 11.8 0.0 2.2 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain NAD_binding_8 PF13450.6 CDK97686.1 - 0.42 10.9 5.8 2 8.7 0.0 3.8 4 0 0 4 4 3 0 NAD(P)-binding Rossmann-like domain HATPase_c PF02518.26 CDK97687.1 - 6.4e-25 87.8 0.0 1e-24 87.2 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 CDK97687.1 - 2.9e-23 81.9 0.1 2.7e-22 78.9 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 CDK97687.1 - 2.8e-20 72.6 4.8 7.6e-13 48.7 0.3 3.1 3 0 0 3 3 3 2 PAS fold HisKA PF00512.25 CDK97687.1 - 9.9e-18 63.9 0.0 4.4e-17 61.9 0.0 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CDK97687.1 - 4.8e-12 45.9 0.1 5.1e-07 29.7 0.1 3.1 3 0 0 3 3 3 2 PAS fold PAS_9 PF13426.7 CDK97687.1 - 6.7e-09 35.9 0.0 0.00058 20.1 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.7 CDK97687.1 - 4.3e-07 29.8 0.1 3.2e-06 27.0 0.1 2.6 2 0 0 2 2 2 1 PAS domain PAS_7 PF12860.7 CDK97687.1 - 6.2e-07 29.6 0.1 4.5e-06 26.8 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_10 PF13596.6 CDK97687.1 - 7.6e-05 23.3 0.0 0.055 14.1 0.0 2.7 3 0 0 3 3 3 2 PAS domain HATPase_c_3 PF13589.6 CDK97687.1 - 0.06 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pox_A_type_inc PF04508.12 CDK97687.1 - 0.13 12.1 1.8 0.33 10.9 1.8 1.7 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Pyr_redox_2 PF07992.14 CDK97688.1 - 5.5e-66 222.8 3.6 6.9e-66 222.5 3.6 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDK97688.1 - 2.3e-33 114.7 1.8 2.6e-33 114.6 0.4 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDK97688.1 - 1.6e-20 73.4 4.8 2.4e-18 66.5 0.4 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDK97688.1 - 1.2e-15 57.5 0.5 2.3e-14 53.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDK97688.1 - 2.2e-05 23.4 2.2 0.25 10.0 0.0 3.1 3 0 0 3 3 3 2 HI0933-like protein K_oxygenase PF13434.6 CDK97688.1 - 6.2e-05 22.3 0.1 0.002 17.4 0.0 2.2 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 CDK97688.1 - 0.0006 19.3 2.9 0.001 18.5 2.9 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDK97688.1 - 0.0082 15.3 7.7 0.15 11.1 2.5 3.5 3 1 0 3 3 3 1 FAD binding domain GIDA PF01134.22 CDK97688.1 - 0.022 13.8 5.0 0.032 13.3 4.3 1.7 1 1 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.17 CDK97688.1 - 0.084 12.1 1.4 0.23 10.7 0.7 2.1 2 0 0 2 2 2 0 Thi4 family NAD_binding_9 PF13454.6 CDK97688.1 - 0.16 12.0 2.0 0.21 11.6 0.0 2.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 CDK97688.1 - 3.6 6.8 9.7 1.7 7.9 1.2 3.0 3 1 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain Polbeta PF18765.1 CDK97689.1 - 0.00079 19.5 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 CDK97689.1 - 0.01 16.1 0.1 0.23 11.8 0.1 2.0 1 1 0 1 1 1 0 Nucleotidyltransferase domain DUF86 PF01934.17 CDK97690.1 - 0.0053 16.6 0.0 0.0061 16.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF86 BAMBI PF06211.12 CDK97690.1 - 0.073 13.3 0.0 0.099 12.9 0.0 1.2 1 0 0 1 1 1 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain Radical_SAM PF04055.21 CDK97691.1 - 3.7e-10 40.4 0.0 6.6e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily CP_ATPgrasp_2 PF14403.6 CDK97692.1 - 1.8e-162 540.6 0.0 2.1e-162 540.3 0.0 1.0 1 0 0 1 1 1 1 Circularly permuted ATP-grasp type 2 CP_ATPgrasp_1 PF04174.13 CDK97692.1 - 3.4e-156 519.4 0.1 4.3e-156 519.0 0.1 1.1 1 0 0 1 1 1 1 A circularly permuted ATPgrasp Alpha-E PF04168.12 CDK97693.1 - 2.5e-90 303.2 1.2 2.8e-90 303.1 1.2 1.0 1 0 0 1 1 1 1 A predicted alpha-helical domain with a conserved ER motif. BRCT_3 PF18428.1 CDK97693.1 - 0.2 11.7 0.0 1.1 9.4 0.0 2.0 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Proteasome PF00227.26 CDK97694.1 - 1.9e-06 27.5 0.0 2.4e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 Proteasome subunit eIF-1a PF01176.19 CDK97694.1 - 0.079 12.8 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 ICEA PF05315.11 CDK97695.1 - 0.18 11.3 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 ICEA Protein SAF PF08666.12 CDK97696.1 - 6.4e-05 23.5 0.3 0.00015 22.3 0.3 1.7 1 0 0 1 1 1 1 SAF domain GFO_IDH_MocA PF01408.22 CDK97696.1 - 0.003 18.4 0.1 0.0074 17.1 0.1 1.7 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold TruB_C PF09142.11 CDK97696.1 - 0.46 10.3 4.8 12 5.7 0.0 3.5 3 0 0 3 3 3 0 tRNA Pseudouridine synthase II, C terminal AAA_PrkA PF08298.11 CDK97698.1 - 2.9e-176 585.7 0.0 3.7e-176 585.3 0.0 1.1 1 0 0 1 1 1 1 PrkA AAA domain PrkA PF06798.12 CDK97698.1 - 4.2e-74 249.4 3.0 5.7e-74 249.0 3.0 1.2 1 0 0 1 1 1 1 PrkA serine protein kinase C-terminal domain AAA_16 PF13191.6 CDK97698.1 - 0.00044 20.7 0.0 0.0012 19.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 CDK97698.1 - 0.0045 17.0 0.1 0.099 12.6 0.1 2.9 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDK97698.1 - 0.031 14.6 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF444 PF04285.12 CDK97699.1 - 4.8e-172 572.8 0.0 5.5e-172 572.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF444) VWA_CoxE PF05762.14 CDK97699.1 - 0.023 14.1 0.9 0.064 12.6 1.0 1.8 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein SpoVR PF04293.13 CDK97700.1 - 9.1e-164 545.1 0.2 1e-163 544.9 0.2 1.0 1 0 0 1 1 1 1 SpoVR like protein Acetyltransf_1 PF00583.25 CDK97701.1 - 2.7e-08 34.1 0.0 3.3e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CDK97701.1 - 2.5e-06 28.2 0.0 3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDK97701.1 - 0.00061 19.7 0.0 0.00082 19.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDK97701.1 - 0.05 13.7 0.0 1.3 9.1 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDK97701.1 - 0.16 12.4 0.0 0.24 11.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDK97701.1 - 0.18 12.0 0.0 6.8 6.9 0.0 2.2 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase SET PF00856.28 CDK97702.1 - 2.7e-13 50.7 0.2 5e-11 43.3 0.2 2.1 1 1 0 1 1 1 1 SET domain SET PF00856.28 CDK97703.1 - 8.4e-13 49.1 0.2 1.4e-10 41.8 0.2 2.1 1 1 0 1 1 1 1 SET domain cNMP_binding PF00027.29 CDK97704.1 - 3e-21 75.3 0.1 8.7e-21 73.8 0.1 1.9 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HEAT_2 PF13646.6 CDK97704.1 - 1.7e-14 54.0 29.0 5.6e-06 26.7 4.3 5.2 3 3 2 5 5 5 3 HEAT repeats MFS_1 PF07690.16 CDK97704.1 - 4.4e-07 29.1 27.6 4.4e-07 29.1 27.6 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily HEAT PF02985.22 CDK97704.1 - 0.00013 21.9 13.7 9 6.9 0.0 6.8 6 0 0 6 6 6 3 HEAT repeat MFS_1_like PF12832.7 CDK97704.1 - 0.01 14.8 3.8 0.027 13.4 3.7 1.7 1 1 0 1 1 1 1 MFS_1 like family tRNA-synt_1c PF00749.21 CDK97705.1 - 9.2e-68 228.4 0.0 1.1e-67 228.2 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1e PF01406.19 CDK97706.1 - 1.5e-118 395.5 0.0 1.8e-118 395.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DALR_2 PF09190.11 CDK97706.1 - 2.9e-14 53.3 0.1 6.9e-14 52.1 0.1 1.7 1 0 0 1 1 1 1 DALR domain tRNA-synt_1g PF09334.11 CDK97706.1 - 1.8e-07 30.2 0.0 0.00011 21.1 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1f PF01921.18 CDK97706.1 - 1.4e-06 27.5 0.0 0.00025 20.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (K) tRNA-synt_1 PF00133.22 CDK97706.1 - 4.2e-05 22.0 0.0 7.9e-05 21.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Terminase_5 PF06056.12 CDK97707.1 - 0.009 15.9 0.2 0.009 15.9 0.2 2.5 3 0 0 3 3 3 1 Putative ATPase subunit of terminase (gpP-like) Herpes_US9 PF06072.11 CDK97707.1 - 0.069 13.0 0.3 0.53 10.2 0.2 2.5 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 NicO PF03824.16 CDK97708.1 - 6.7e-26 91.3 22.4 5.4e-17 62.1 4.2 2.1 1 1 1 2 2 2 2 High-affinity nickel-transport protein DUF1007 PF06226.13 CDK97709.1 - 6.8e-38 130.8 0.0 1.1e-37 130.1 0.0 1.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1007) DUF2442 PF10387.9 CDK97709.1 - 0.0054 17.0 0.0 0.021 15.1 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF2442) EF-hand_5 PF13202.6 CDK97709.1 - 0.011 15.2 0.0 0.025 14.1 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.32 CDK97709.1 - 0.052 13.1 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 EF hand Cys_Met_Meta_PP PF01053.20 CDK97710.1 - 7.9e-93 311.0 0.0 9e-93 310.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CDK97710.1 - 2.2e-06 27.2 0.0 3.7e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CDK97710.1 - 0.0021 17.1 0.0 0.0032 16.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V AAA_31 PF13614.6 CDK97712.1 - 3.7e-41 141.0 0.0 6.2e-41 140.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CDK97712.1 - 2.2e-17 63.3 0.0 4.1e-17 62.4 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 CDK97712.1 - 1.1e-07 31.6 0.0 1.9e-07 30.8 0.0 1.6 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase MipZ PF09140.11 CDK97712.1 - 6.1e-06 25.7 0.1 0.0016 17.8 0.1 2.2 2 0 0 2 2 2 2 ATPase MipZ CBP_BcsQ PF06564.12 CDK97712.1 - 6.7e-06 25.7 0.0 1.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ SRP54 PF00448.22 CDK97712.1 - 0.0035 17.0 0.3 0.34 10.5 0.1 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_NifH PF00142.18 CDK97712.1 - 0.0066 15.9 0.1 0.014 14.9 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 CDK97712.1 - 0.02 14.1 0.2 0.033 13.4 0.2 1.3 1 0 0 1 1 1 0 Anion-transporting ATPase RadC PF04002.15 CDK97713.1 - 4.6e-43 146.0 0.0 7.7e-43 145.3 0.0 1.3 1 0 0 1 1 1 1 RadC-like JAB domain Prok-JAB PF14464.6 CDK97713.1 - 0.0001 22.1 0.0 0.00016 21.4 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain HHH_5 PF14520.6 CDK97713.1 - 0.0065 17.0 0.2 0.015 15.9 0.2 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain MCPsignal PF00015.21 CDK97714.1 - 1.5e-31 109.5 29.3 1.5e-31 109.5 29.3 4.1 1 1 2 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK97714.1 - 1.9e-10 40.9 0.2 1.9e-10 40.9 0.2 4.4 5 0 0 5 5 5 1 HAMP domain Hemerythrin PF01814.23 CDK97714.1 - 6.3e-06 26.8 6.9 6.3e-06 26.8 6.9 3.6 3 1 0 3 3 3 1 Hemerythrin HHE cation binding domain DUF948 PF06103.11 CDK97714.1 - 0.76 10.1 36.7 4.6 7.6 8.1 6.7 3 1 2 5 5 5 0 Bacterial protein of unknown function (DUF948) HTH_Tnp_IS630 PF01710.16 CDK97715.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK97715.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK97715.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK97715.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK97715.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK97715.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDK97716.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK97716.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain AphA_like PF14557.6 CDK97717.1 - 1.1e-87 292.3 3.1 1.2e-87 292.1 3.1 1.0 1 0 0 1 1 1 1 Putative AphA-like transcriptional regulator Vir_act_alpha_C PF10400.9 CDK97717.1 - 0.19 12.5 3.0 0.35 11.6 3.0 1.5 1 0 0 1 1 1 0 Virulence activator alpha C-term Amidohydro_1 PF01979.20 CDK97719.1 - 2e-21 76.7 0.0 1.1e-20 74.2 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CDK97719.1 - 2.6e-07 30.5 4.3 4.5e-05 23.1 1.0 3.2 2 1 0 2 2 2 2 Amidohydrolase family Urease_alpha PF00449.20 CDK97719.1 - 0.003 17.9 0.1 0.0092 16.3 0.1 1.9 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain PTH2 PF01981.16 CDK97719.1 - 0.14 12.5 0.5 0.39 11.0 0.0 2.0 2 1 0 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 Asn_synthase PF00733.21 CDK97720.1 - 9.7e-77 259.0 0.0 1.2e-76 258.7 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CDK97720.1 - 8.5e-36 122.6 0.0 2.2e-35 121.2 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDK97720.1 - 1.4e-27 96.5 0.0 1.3e-26 93.4 0.0 2.4 2 1 0 2 2 2 1 Glutamine amidotransferase domain NAD_synthase PF02540.17 CDK97720.1 - 0.013 14.6 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 NAD synthase QueC PF06508.13 CDK97720.1 - 0.19 11.2 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Glycos_transf_1 PF00534.20 CDK97721.1 - 2.7e-33 114.9 0.0 4e-33 114.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDK97721.1 - 1.6e-31 109.5 0.1 2.7e-31 108.8 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDK97721.1 - 1.1e-07 32.2 0.0 3.4e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDK97721.1 - 1.2e-07 32.3 2.8 8.1e-06 26.4 1.2 3.0 2 1 1 3 3 3 2 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CDK97721.1 - 3.2e-06 27.2 2.6 0.00037 20.5 1.5 3.0 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CDK97722.1 - 5.6e-09 36.5 0.0 1e-08 35.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDK97722.1 - 9.8e-07 29.1 0.0 1.8e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDK97722.1 - 2.6e-06 27.1 0.0 3.9e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDK97722.1 - 0.0025 17.8 0.0 0.005 16.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CDK97722.1 - 2.2 8.7 10.3 33 4.9 10.3 2.5 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain GCV_T PF01571.21 CDK97723.1 - 1e-10 41.4 0.0 2.1e-10 40.4 0.0 1.4 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain GGDEF PF00990.21 CDK97724.1 - 6.2e-52 175.6 0.0 1.2e-51 174.7 0.0 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDK97724.1 - 1.2e-19 70.5 0.0 5.1e-15 55.6 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 CDK97724.1 - 1.5e-18 66.9 0.1 1.3e-12 47.7 0.0 3.0 3 1 0 3 3 3 2 PAS fold PAS_8 PF13188.7 CDK97724.1 - 2.8e-16 59.1 0.9 1.2e-09 37.9 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 CDK97724.1 - 1.5e-13 50.9 0.1 2.7e-11 43.7 0.0 2.8 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 CDK97724.1 - 0.023 15.0 0.0 2.7 8.3 0.0 2.9 2 0 0 2 2 2 0 PAS fold PAS_7 PF12860.7 CDK97724.1 - 0.027 14.7 0.1 0.27 11.4 0.0 2.8 3 1 0 3 3 3 0 PAS fold MeaB PF03308.16 CDK97725.1 - 3.4e-73 245.9 2.3 4.2e-73 245.6 2.3 1.0 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 CDK97725.1 - 5.3e-08 32.9 0.1 0.00044 20.1 0.0 3.1 2 1 0 2 2 2 2 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 CDK97725.1 - 2.2e-06 27.7 0.0 0.0047 16.8 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 CDK97725.1 - 9.8e-06 25.4 0.1 2.7e-05 24.0 0.1 1.8 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CDK97725.1 - 2.9e-05 24.1 0.0 8.6e-05 22.6 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 CDK97725.1 - 5.6e-05 22.8 0.1 0.0011 18.6 0.1 2.5 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 CDK97725.1 - 0.0019 18.7 0.0 0.0053 17.3 0.0 1.7 2 0 0 2 2 1 1 ABC transporter NTPase_1 PF03266.15 CDK97725.1 - 0.0029 17.5 0.0 0.0059 16.5 0.0 1.5 1 0 0 1 1 1 1 NTPase AAA_18 PF13238.6 CDK97725.1 - 0.0036 17.8 0.1 0.013 16.1 0.0 2.1 4 0 0 4 4 1 1 AAA domain GTP_EFTU PF00009.27 CDK97725.1 - 0.0042 16.7 0.0 0.12 11.9 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_28 PF13521.6 CDK97725.1 - 0.0053 17.0 0.1 0.2 11.9 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CDK97725.1 - 0.01 16.2 0.2 0.045 14.1 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain NACHT PF05729.12 CDK97725.1 - 0.011 15.6 0.3 0.042 13.8 0.1 2.0 3 0 0 3 3 2 0 NACHT domain AAA PF00004.29 CDK97725.1 - 0.014 15.8 0.1 0.081 13.3 0.0 2.3 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 CDK97725.1 - 0.014 15.3 0.0 0.077 12.9 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.23 CDK97725.1 - 0.015 15.3 0.0 0.055 13.5 0.0 1.9 1 1 1 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_29 PF13555.6 CDK97725.1 - 0.016 14.9 0.0 0.038 13.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_26 PF13500.6 CDK97725.1 - 0.025 14.4 0.0 7.3 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 CDK97725.1 - 0.027 14.0 0.1 0.41 10.2 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.6 CDK97725.1 - 0.027 14.2 0.0 0.053 13.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDK97725.1 - 0.031 14.4 0.1 0.17 12.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 CDK97725.1 - 0.041 12.8 0.0 0.068 12.1 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_22 PF13401.6 CDK97725.1 - 0.055 13.8 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDK97725.1 - 0.079 13.4 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 CDK97725.1 - 0.085 12.6 0.1 0.27 10.9 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein CLP1_P PF16575.5 CDK97725.1 - 0.11 12.3 0.0 0.5 10.1 0.0 2.0 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NB-ARC PF00931.22 CDK97725.1 - 0.2 10.8 0.0 0.31 10.2 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain DsbB PF02600.16 CDK97726.1 - 2.9e-32 112.1 11.7 3.4e-32 111.9 11.7 1.0 1 0 0 1 1 1 1 Disulfide bond formation protein DsbB COQ7 PF03232.13 CDK97727.1 - 1e-68 230.4 0.2 1.2e-68 230.3 0.2 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 CDK97727.1 - 0.0018 18.7 0.0 0.0032 17.9 0.0 1.4 1 1 0 1 1 1 1 Rubrerythrin Ferritin_2 PF13668.6 CDK97727.1 - 0.046 13.9 2.4 0.74 10.0 0.9 2.4 1 1 1 2 2 2 0 Ferritin-like domain Peptidase_M48 PF01435.18 CDK97729.1 - 2.3e-27 96.1 0.2 4.7e-27 95.1 0.2 1.5 1 1 0 1 1 1 1 Peptidase family M48 DUF4157 PF13699.6 CDK97729.1 - 0.0096 16.1 2.1 0.062 13.5 0.3 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4157) DUF2201_N PF13203.6 CDK97729.1 - 0.013 15.1 0.1 0.027 14.1 0.1 1.5 1 0 0 1 1 1 0 Putative metallopeptidase domain BSP PF04450.12 CDK97729.1 - 0.083 12.7 0.2 0.22 11.3 0.2 1.7 1 1 1 2 2 2 0 Peptidase of plants and bacteria SprT-like PF10263.9 CDK97729.1 - 0.2 11.5 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 SprT-like family DUF883 PF05957.13 CDK97729.1 - 1.2 9.8 4.6 2.3 8.8 0.4 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF898 PF05987.13 CDK97730.1 - 9.8e-81 271.5 20.1 1.1e-80 271.3 20.1 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) EIID-AGA PF03613.14 CDK97730.1 - 0.015 14.5 2.2 0.024 13.8 2.2 1.3 1 0 0 1 1 1 0 PTS system mannose/fructose/sorbose family IID component DUF2208 PF09973.9 CDK97730.1 - 9.3 5.8 8.4 0.42 10.2 2.8 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) Oxidored_molyb PF00174.19 CDK97731.1 - 4.6e-30 104.5 0.0 6.6e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain TAT_signal PF10518.9 CDK97731.1 - 1.8 8.5 8.4 3.3 7.7 8.4 1.5 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence Ferric_reduct PF01794.19 CDK97732.1 - 2.2e-16 60.1 10.9 4.3e-16 59.2 10.9 1.6 1 1 0 1 1 1 1 Ferric reductase like transmembrane component YpmT PF17431.2 CDK97734.1 - 0.016 15.2 1.1 0.024 14.7 1.1 1.3 1 1 0 1 1 1 0 Uncharacterized YmpT-like CBM_48 PF02922.18 CDK97735.1 - 1.5e-26 92.5 0.0 2.4e-22 79.1 0.0 3.1 3 0 0 3 3 3 2 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C PF02806.18 CDK97735.1 - 1.9e-24 85.9 0.0 1.5e-23 83.1 0.0 2.2 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 CDK97735.1 - 1.5e-12 47.7 0.0 1.7e-06 27.9 0.0 2.8 1 1 0 2 2 2 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 CDK97736.1 - 2.1e-20 72.9 0.0 4.1e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 CDK97736.1 - 1.5e-18 67.5 0.1 9.1e-11 41.9 0.0 3.1 2 1 1 3 3 3 3 Alpha amylase, catalytic domain DUF3459 PF11941.8 CDK97736.1 - 0.078 13.3 0.1 0.21 11.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3459) Glyco_hydro_77 PF02446.17 CDK97737.1 - 2.4e-114 382.8 0.0 3.2e-114 382.4 0.0 1.1 1 0 0 1 1 1 1 4-alpha-glucanotransferase Phosphorylase PF00343.20 CDK97738.1 - 0 1091.7 0.0 0 1091.4 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Fringe PF02434.16 CDK97738.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Fringe-like HTH_Tnp_IS630 PF01710.16 CDK97739.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK97739.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK97739.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK97739.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK97739.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK97739.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDK97740.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK97740.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain TF_Zn_Ribbon PF08271.12 CDK97741.1 - 0.063 12.8 0.0 0.091 12.3 0.0 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding AhpC-TSA PF00578.21 CDK97743.1 - 1.7e-17 63.5 0.0 2.3e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDK97743.1 - 7.6e-11 41.9 0.0 1e-10 41.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 CDK97743.1 - 0.016 15.7 0.0 0.029 14.8 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain TPR_21 PF09976.9 CDK97744.1 - 1.5e-15 57.5 12.7 3.2e-15 56.3 9.9 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat-like domain TPR_19 PF14559.6 CDK97744.1 - 0.01 16.3 15.6 0.75 10.3 0.7 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat CcmD PF04995.14 CDK97744.1 - 0.031 14.3 0.8 0.095 12.8 0.8 1.8 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) TPR_14 PF13428.6 CDK97744.1 - 0.058 14.2 15.4 0.62 11.0 1.8 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDK97744.1 - 0.14 12.8 9.5 0.97 10.2 0.2 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDK97744.1 - 0.19 12.4 19.7 1.2 9.8 1.3 3.9 2 2 1 3 3 3 0 Tetratricopeptide repeat GspL_C PF12693.7 CDK97744.1 - 0.21 11.4 3.3 0.26 11.1 1.1 2.1 2 0 0 2 2 2 0 GspL periplasmic domain TPR_4 PF07721.14 CDK97744.1 - 6 7.8 17.1 1.7 9.5 1.5 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat PQQ_2 PF13360.6 CDK97745.1 - 2.9e-71 239.8 7.2 1.5e-65 221.1 5.0 3.0 2 1 1 3 3 3 3 PQQ-like domain PQQ_3 PF13570.6 CDK97745.1 - 4.7e-31 106.4 12.9 7.3e-05 23.1 0.0 8.5 8 0 0 8 8 8 8 PQQ-like domain PQQ PF01011.21 CDK97745.1 - 7.1e-25 85.7 7.2 0.00077 19.3 0.0 8.5 10 0 0 10 10 10 6 PQQ enzyme repeat Glu_cyclase_2 PF05096.12 CDK97745.1 - 0.011 15.2 0.1 0.044 13.2 0.0 2.0 2 0 0 2 2 2 0 Glutamine cyclotransferase Glyco_hydro_42C PF08533.10 CDK97745.1 - 0.014 15.1 0.0 0.03 14.0 0.0 1.5 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain DUF799 PF05643.11 CDK97745.1 - 0.015 14.9 0.5 24 4.4 0.0 3.7 4 0 0 4 4 4 0 Putative bacterial lipoprotein (DUF799) PepSY PF03413.19 CDK97745.1 - 0.21 12.2 0.2 53 4.5 0.0 3.1 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain MMR_HSR1 PF01926.23 CDK97746.1 - 4.1e-52 175.1 0.1 4.4e-28 97.7 0.0 2.2 2 0 0 2 2 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.6 CDK97746.1 - 9.5e-34 115.6 0.1 1.7e-33 114.8 0.1 1.4 1 0 0 1 1 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 CDK97746.1 - 3.9e-30 104.4 0.0 2.2e-14 53.3 0.1 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDK97746.1 - 5.8e-21 74.9 1.0 3.4e-10 39.8 0.5 5.2 3 2 1 4 4 4 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CDK97746.1 - 9.3e-14 51.8 0.7 0.0039 17.3 0.0 4.2 2 2 2 4 4 4 3 Dynamin family AIG1 PF04548.16 CDK97746.1 - 5.6e-13 48.7 0.0 4.1e-07 29.6 0.0 2.2 2 0 0 2 2 2 2 AIG1 family RsgA_GTPase PF03193.16 CDK97746.1 - 8.4e-10 38.8 0.0 0.018 15.0 0.0 3.8 3 0 0 3 3 3 3 RsgA GTPase Roc PF08477.13 CDK97746.1 - 1.3e-08 35.1 0.0 0.0032 17.7 0.0 3.1 3 1 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDK97746.1 - 3.9e-08 33.1 0.0 0.0048 16.5 0.0 2.9 2 1 0 2 2 2 2 Ras family MeaB PF03308.16 CDK97746.1 - 6.3e-08 31.9 0.3 0.12 11.3 0.2 4.1 4 0 0 4 4 4 3 Methylmalonyl Co-A mutase-associated GTPase MeaB Septin PF00735.18 CDK97746.1 - 7.3e-06 25.5 0.0 0.072 12.4 0.0 2.9 2 1 0 2 2 2 2 Septin TniB PF05621.11 CDK97746.1 - 1.9e-05 24.2 0.1 0.014 14.8 0.0 2.8 3 0 0 3 3 3 1 Bacterial TniB protein Arf PF00025.21 CDK97746.1 - 3.2e-05 23.4 0.1 0.21 11.1 0.0 3.4 3 0 0 3 3 3 1 ADP-ribosylation factor family ABC_tran PF00005.27 CDK97746.1 - 4.8e-05 23.9 0.0 0.46 11.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PduV-EutP PF10662.9 CDK97746.1 - 5.6e-05 22.9 0.0 0.26 11.0 0.0 3.8 4 0 0 4 4 4 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 CDK97746.1 - 5.6e-05 22.6 0.0 0.13 11.7 0.0 2.6 2 1 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 CDK97746.1 - 0.0001 22.6 0.1 0.25 11.6 0.0 3.1 2 2 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CDK97746.1 - 0.00014 22.4 0.0 0.93 10.0 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 CDK97746.1 - 0.0003 21.1 0.0 0.32 11.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 CDK97746.1 - 0.00037 20.3 0.0 0.57 9.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CDK97746.1 - 0.0013 19.1 0.0 2.8 8.4 0.0 2.8 3 0 0 3 3 2 2 RNA helicase NTPase_1 PF03266.15 CDK97746.1 - 0.002 18.1 0.0 2.3 8.1 0.0 2.5 2 0 0 2 2 2 2 NTPase AAA_16 PF13191.6 CDK97746.1 - 0.0022 18.4 0.4 0.65 10.4 0.2 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 CDK97746.1 - 0.0056 16.8 0.3 5.6 7.1 0.0 3.3 2 2 1 3 3 3 0 AAA domain cobW PF02492.19 CDK97746.1 - 0.0069 16.0 2.9 1.5 8.4 0.3 3.5 3 1 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 CDK97746.1 - 0.016 15.0 0.0 7.1 6.5 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 CDK97746.1 - 0.046 13.6 0.0 9 6.1 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea FtsK_SpoIIIE PF01580.18 CDK97746.1 - 0.054 12.8 0.0 2.2 7.6 0.0 2.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family NB-ARC PF00931.22 CDK97746.1 - 0.066 12.4 0.0 8.1 5.5 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain ATP_bind_1 PF03029.17 CDK97746.1 - 0.076 12.8 0.0 14 5.4 0.0 3.2 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 CDK97746.1 - 0.08 13.0 0.0 24 5.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain MobB PF03205.14 CDK97746.1 - 0.095 12.6 0.0 10 6.0 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF155 PF02582.14 CDK97747.1 - 8.3e-26 91.1 0.0 1.1e-25 90.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 HycA_repressor PF11046.8 CDK97747.1 - 0.0031 17.7 0.0 0.033 14.4 0.0 2.2 2 0 0 2 2 2 1 Transcriptional repressor of hyc and hyp operons Abhydrolase_3 PF07859.13 CDK97748.1 - 1.2e-59 201.8 0.1 1.6e-59 201.3 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CDK97748.1 - 2.5e-07 29.9 0.0 3.5e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 CDK97748.1 - 2.2e-06 26.8 0.0 0.04 12.8 0.2 2.3 2 0 0 2 2 2 2 Carboxylesterase family DLH PF01738.18 CDK97748.1 - 0.0021 17.6 0.0 0.0036 16.9 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CDK97748.1 - 0.016 14.7 0.2 5.1 6.5 0.1 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Apolipoprotein PF01442.18 CDK97749.1 - 2.6e-08 34.0 104.8 0.078 12.8 36.4 6.8 2 1 4 6 6 6 5 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 CDK97749.1 - 0.003 17.6 43.3 0.11 12.5 0.2 8.0 3 1 6 9 9 9 3 Protein of unknown function (DUF1664) ApoLp-III PF07464.11 CDK97749.1 - 0.0077 16.3 53.5 0.3 11.2 7.0 6.1 1 1 3 5 5 5 3 Apolipophorin-III precursor (apoLp-III) Tup_N PF08581.10 CDK97749.1 - 0.094 13.0 0.0 0.094 13.0 0.0 5.6 7 0 0 7 7 7 0 Tup N-terminal PspB PF06667.12 CDK97749.1 - 0.31 11.1 0.0 0.31 11.1 0.0 6.2 7 1 1 8 8 8 0 Phage shock protein B Utp12 PF04003.12 CDK97749.1 - 2.9 8.2 13.6 1.4 9.2 0.3 5.6 4 2 2 6 6 6 0 Dip2/Utp12 Family Response_reg PF00072.24 CDK97750.1 - 6.6e-46 155.1 6.6 4.9e-27 94.3 1.8 2.8 3 0 0 3 3 3 2 Response regulator receiver domain HATPase_c PF02518.26 CDK97750.1 - 5.7e-29 100.9 0.1 2.8e-28 98.7 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK97750.1 - 3e-21 75.2 1.2 1.8e-20 72.7 0.0 3.1 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 CDK97750.1 - 9.6e-18 64.3 0.0 1.1e-08 35.2 0.0 3.0 2 0 0 2 2 2 2 PAS fold Hpt PF01627.23 CDK97750.1 - 3e-12 46.6 3.2 3e-12 46.6 3.2 3.2 2 1 1 3 3 3 1 Hpt domain dCache_1 PF02743.18 CDK97750.1 - 4.9e-12 46.2 0.0 8.7e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Cache domain PAS_4 PF08448.10 CDK97750.1 - 4e-08 33.5 0.4 0.003 17.8 0.0 3.3 2 0 0 2 2 2 2 PAS fold HAMP PF00672.25 CDK97750.1 - 0.001 19.4 2.5 0.0037 17.6 2.5 2.1 1 0 0 1 1 1 1 HAMP domain PAS PF00989.25 CDK97750.1 - 0.0016 18.5 0.0 0.013 15.4 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDK97750.1 - 0.0025 17.8 0.1 0.27 11.3 0.0 3.1 2 0 0 2 2 2 1 PAS domain Response_reg PF00072.24 CDK97751.1 - 2.6e-27 95.2 0.0 5.3e-27 94.2 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HD PF01966.22 CDK97751.1 - 4.9e-17 62.3 1.6 8.8e-17 61.5 0.1 2.1 2 1 0 2 2 2 1 HD domain HD_5 PF13487.6 CDK97751.1 - 1.6e-16 60.3 0.0 5.3e-16 58.6 0.0 2.0 1 0 0 1 1 1 1 HD domain Response_reg PF00072.24 CDK97752.1 - 2.4e-23 82.5 0.2 7.8e-23 80.8 0.0 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HD_5 PF13487.6 CDK97752.1 - 4.4e-19 68.5 0.1 1.5e-18 66.8 0.1 2.0 1 0 0 1 1 1 1 HD domain HD PF01966.22 CDK97752.1 - 1.1e-17 64.4 0.4 4.2e-17 62.5 0.3 2.0 2 0 0 2 2 2 1 HD domain CPSase_L_D2 PF02786.17 CDK97753.1 - 4e-82 274.8 0.0 5.5e-82 274.4 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CDK97753.1 - 5.4e-47 158.9 0.1 1.5e-46 157.5 0.1 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDK97753.1 - 7.3e-40 135.4 0.0 1.5e-39 134.4 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 CDK97753.1 - 4.1e-10 39.5 0.0 1e-09 38.3 0.0 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CDK97753.1 - 7.2e-09 35.4 0.0 1.5e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 CDK97753.1 - 0.0003 20.9 0.0 0.0011 19.0 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 CDK97753.1 - 0.058 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.19 CDK97753.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 CDK97753.1 - 0.15 11.3 0.0 0.32 10.2 0.0 1.5 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Biotin_lipoyl PF00364.22 CDK97754.1 - 2.7e-16 59.1 0.0 4.2e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDK97754.1 - 2.6e-06 27.2 0.0 0.00023 20.9 0.0 2.3 1 1 1 2 2 2 2 Biotin-lipoyl like DHquinase_II PF01220.19 CDK97755.1 - 1.3e-61 206.3 0.2 1.4e-61 206.2 0.2 1.0 1 0 0 1 1 1 1 Dehydroquinase class II AurF PF11583.8 CDK97755.1 - 0.024 13.9 0.3 0.031 13.6 0.3 1.2 1 0 0 1 1 1 0 P-aminobenzoate N-oxygenase AurF Arabinose_Isome PF02610.15 CDK97755.1 - 0.14 11.4 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 L-arabinose isomerase AsmA PF05170.14 CDK97756.1 - 0.00087 18.2 0.0 0.0012 17.7 0.0 1.2 1 0 0 1 1 1 1 AsmA family LPAM_1 PF08139.12 CDK97756.1 - 0.26 11.9 2.2 1 10.0 2.2 2.1 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site ThiG PF05690.14 CDK97757.1 - 8.5e-110 365.9 0.6 1e-109 365.6 0.6 1.1 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG ThiS PF02597.20 CDK97757.1 - 1.6e-09 38.2 0.2 3.1e-09 37.3 0.2 1.5 1 0 0 1 1 1 1 ThiS family His_biosynth PF00977.21 CDK97757.1 - 0.0006 19.3 0.3 0.006 16.1 0.1 2.0 2 0 0 2 2 2 1 Histidine biosynthesis protein NanE PF04131.14 CDK97757.1 - 0.0064 15.7 1.4 6.6 5.9 0.0 3.1 2 1 1 3 3 3 2 Putative N-acetylmannosamine-6-phosphate epimerase FMN_dh PF01070.18 CDK97757.1 - 0.011 14.8 0.8 0.02 14.0 0.8 1.3 1 0 0 1 1 1 0 FMN-dependent dehydrogenase SOR_SNZ PF01680.17 CDK97757.1 - 0.096 12.5 0.8 0.23 11.2 0.8 1.7 1 0 0 1 1 1 0 SOR/SNZ family Dus PF01207.17 CDK97757.1 - 0.11 11.6 0.2 0.32 10.0 0.2 1.7 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) IMPDH PF00478.25 CDK97757.1 - 0.16 10.9 3.1 0.56 9.1 1.5 2.0 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain Orn_Arg_deC_N PF02784.16 CDK97758.1 - 4.9e-53 180.0 0.0 6.2e-53 179.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CDK97758.1 - 1.3e-09 38.1 0.0 1.4e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain CP12 PF02672.15 CDK97759.1 - 0.1 13.3 1.2 0.13 13.0 1.2 1.2 1 0 0 1 1 1 0 CP12 domain COX3 PF00510.18 CDK97762.1 - 1.2e-94 316.9 19.5 1.4e-94 316.8 19.5 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit III DUF202 PF02656.15 CDK97762.1 - 0.45 11.0 19.8 0.19 12.2 0.7 3.6 3 2 1 4 4 4 0 Domain of unknown function (DUF202) CtaG_Cox11 PF04442.14 CDK97763.1 - 2.5e-57 193.2 0.0 3e-57 192.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 COX1 PF00115.20 CDK97764.1 - 4.6e-158 526.6 66.7 5.9e-158 526.3 66.7 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I COX2 PF00116.20 CDK97765.1 - 2.1e-55 185.8 0.0 3.2e-55 185.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain COX2_TM PF02790.15 CDK97765.1 - 1.2e-24 86.2 0.8 1.9e-24 85.6 0.8 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain SUR7 PF06687.12 CDK97765.1 - 0.017 14.7 0.7 0.026 14.2 0.7 1.2 1 0 0 1 1 1 0 SUR7/PalI family DHHC PF01529.20 CDK97765.1 - 0.06 13.5 1.0 0.097 12.8 1.0 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase Cupredoxin_1 PF13473.6 CDK97765.1 - 0.061 13.4 0.0 0.15 12.2 0.0 1.7 1 1 0 1 1 1 0 Cupredoxin-like domain DUF2892 PF11127.8 CDK97765.1 - 2.5 8.2 8.9 2.7 8.1 6.6 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2892) Rhodanese PF00581.20 CDK97766.1 - 2.8e-13 50.3 0.0 4.7e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Y_phosphatase3 PF13350.6 CDK97766.1 - 0.038 14.0 0.6 6 6.8 0.4 2.0 1 1 1 2 2 2 0 Tyrosine phosphatase family Cytochrome_CBB3 PF13442.6 CDK97767.1 - 1.3e-06 28.6 0.5 1.9e-06 28.1 0.5 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDK97767.1 - 0.00032 21.8 1.9 0.00091 20.3 1.9 1.7 1 1 0 1 1 1 1 Cytochrome c DUF2059 PF09832.9 CDK97767.1 - 1.8 8.7 4.1 0.41 10.7 0.4 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2059) FCSD-flav_bind PF09242.11 CDK97768.1 - 1.8e-26 92.2 0.6 6.8e-26 90.4 0.2 2.1 2 0 0 2 2 2 1 Flavocytochrome c sulphide dehydrogenase, flavin-binding Pyr_redox_2 PF07992.14 CDK97768.1 - 7.6e-18 64.8 0.1 3.1e-13 49.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDK97768.1 - 3.1e-05 24.1 0.0 0.00016 21.8 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDK97768.1 - 6.9e-05 22.6 0.0 0.0021 17.7 0.0 2.2 2 1 0 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CDK97768.1 - 0.00072 18.5 0.0 0.0027 16.6 0.0 1.8 2 0 0 2 2 2 1 Tryptophan halogenase Lycopene_cycl PF05834.12 CDK97768.1 - 0.001 18.2 0.2 0.79 8.7 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox PF00070.27 CDK97768.1 - 0.0013 19.2 0.0 0.017 15.7 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CDK97768.1 - 0.0027 17.0 0.7 0.0081 15.5 0.2 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 CDK97768.1 - 0.0053 15.9 0.2 1.2 8.1 0.1 2.2 1 1 1 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 CDK97768.1 - 0.013 14.7 0.0 0.039 13.2 0.0 1.7 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 CDK97768.1 - 0.016 15.2 0.0 0.7 9.9 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Methyltransf_2 PF00891.18 CDK97768.1 - 0.17 11.2 0.2 3.8 6.7 0.0 2.2 2 0 0 2 2 2 0 O-methyltransferase domain Cytochrome_CBB3 PF13442.6 CDK97770.1 - 3.8e-10 39.9 2.7 0.00012 22.4 0.3 2.4 2 0 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDK97770.1 - 1.9e-06 28.9 7.6 0.062 14.5 1.1 4.0 2 2 1 3 3 3 2 Cytochrome c Cytochrome_C7 PF14522.6 CDK97770.1 - 0.059 13.4 0.0 12 5.9 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Rubredoxin_2 PF18073.1 CDK97770.1 - 4.4 7.1 9.1 0.13 12.0 2.9 1.6 2 0 0 2 2 2 0 Rubredoxin metal binding domain Cytochrom_NNT PF03264.14 CDK97771.1 - 8.4e-64 214.4 1.7 1e-63 214.2 1.7 1.0 1 0 0 1 1 1 1 NapC/NirT cytochrome c family, N-terminal region Cytochrome_C7 PF14522.6 CDK97771.1 - 2.8e-08 33.6 8.9 0.00098 19.1 2.2 2.4 2 0 0 2 2 2 2 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 CDK97771.1 - 8.6e-07 29.3 9.4 0.0027 18.1 0.9 2.3 2 0 0 2 2 2 2 Cytochrome c3 Cytochrom_CIII PF02085.16 CDK97771.1 - 8.7e-06 26.0 9.5 0.02 15.2 1.8 2.3 2 0 0 2 2 2 2 Class III cytochrome C family Paired_CXXCH_1 PF09699.10 CDK97771.1 - 0.00031 20.4 13.0 1.6 8.5 5.1 3.7 3 1 0 3 3 3 3 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_C554 PF13435.6 CDK97771.1 - 0.004 18.0 11.0 0.16 12.9 0.3 2.8 2 1 0 2 2 2 2 Cytochrome c554 and c-prime Cytochrome_CBB3 PF13442.6 CDK97771.1 - 0.0052 17.1 16.5 0.12 12.7 0.1 4.4 1 1 3 4 4 4 1 Cytochrome C oxidase, cbb3-type, subunit III NapB PF03892.14 CDK97771.1 - 0.045 13.8 12.0 0.34 10.9 2.8 3.4 1 1 2 3 3 3 0 Nitrate reductase cytochrome c-type subunit (NapB) Neuropep_like PF15161.6 CDK97771.1 - 0.12 12.1 0.2 0.12 12.1 0.2 3.7 3 1 1 4 4 4 0 Neuropeptide-like GF_recep_IV PF14843.6 CDK97771.1 - 0.13 12.0 5.2 3.3 7.5 0.2 2.3 2 0 0 2 2 2 0 Growth factor receptor domain IV DZR PF12773.7 CDK97771.1 - 0.37 10.8 10.3 1.2 9.2 0.5 2.8 2 1 0 2 2 2 0 Double zinc ribbon Cytochrom_C PF00034.21 CDK97771.1 - 1.8 9.7 17.5 8.7 7.6 2.4 4.2 1 1 2 3 3 3 0 Cytochrome c Cytochrom_C552 PF02335.15 CDK97771.1 - 4.9 6.0 14.2 4.5 6.1 2.5 2.5 2 1 0 2 2 2 0 Cytochrome c552 RQC PF09382.10 CDK97772.1 - 1.2e-34 118.4 0.0 2.6e-34 117.4 0.0 1.6 1 0 0 1 1 1 1 RQC domain HRDC PF00570.23 CDK97772.1 - 1.5e-22 79.4 0.0 3.6e-22 78.1 0.0 1.7 1 0 0 1 1 1 1 HRDC domain DEAD PF00270.29 CDK97772.1 - 2.2e-18 66.6 0.0 3.8e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 CDK97772.1 - 2.7e-17 63.2 2.2 7.1e-17 61.9 2.2 1.8 1 0 0 1 1 1 1 RecQ zinc-binding Helicase_C PF00271.31 CDK97772.1 - 1e-15 58.0 0.0 8.3e-15 55.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Bacillus_PapR PF05968.11 CDK97772.1 - 0.4 10.6 1.5 8.4 6.4 0.2 2.7 2 0 0 2 2 2 0 Bacillus PapR protein PBP_like_2 PF12849.7 CDK97773.1 - 3.9e-40 138.3 0.3 4.5e-40 138.1 0.3 1.0 1 0 0 1 1 1 1 PBP superfamily domain PBP_like PF12727.7 CDK97773.1 - 3.4e-07 29.6 0.0 5.5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 PBP superfamily domain DUF3708 PF12501.8 CDK97774.1 - 2.6e-37 128.2 8.6 2.6e-37 128.2 8.6 2.1 2 0 0 2 2 2 1 Phosphate ATP-binding cassette transporter BPD_transp_1 PF00528.22 CDK97774.1 - 2.2e-18 66.7 14.1 2.2e-18 66.7 14.1 3.1 2 1 2 4 4 4 1 Binding-protein-dependent transport system inner membrane component 2TM PF13239.6 CDK97774.1 - 1.9 8.8 3.4 1.3 9.4 0.3 2.3 2 0 0 2 2 2 0 2TM domain DUF3333 PF11812.8 CDK97775.1 - 2.2e-56 190.3 0.2 4.4e-56 189.3 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3333) BPD_transp_1 PF00528.22 CDK97775.1 - 1.9e-19 70.1 12.8 1.9e-19 70.1 12.8 2.5 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component NdhL PF10716.9 CDK97775.1 - 9.7 6.2 9.8 0.57 10.2 0.2 2.8 3 0 0 3 3 3 0 NADH dehydrogenase transmembrane subunit ABC_tran PF00005.27 CDK97776.1 - 9.7e-30 103.9 0.0 1.4e-29 103.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK97776.1 - 3.4e-12 46.8 0.0 3.3e-05 23.9 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK97776.1 - 4.1e-08 32.9 0.0 4.5e-07 29.5 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CDK97776.1 - 1.7e-05 24.7 0.0 4.7e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 CDK97776.1 - 0.00014 21.5 0.0 0.00026 20.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDK97776.1 - 0.00035 20.5 0.0 0.00075 19.4 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 CDK97776.1 - 0.00067 20.2 0.0 0.0014 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CDK97776.1 - 0.0018 17.9 0.0 0.11 12.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 CDK97776.1 - 0.0039 17.1 0.0 0.0076 16.2 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 CDK97776.1 - 0.0041 16.9 0.0 0.16 11.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDK97776.1 - 0.0069 16.8 0.1 0.018 15.4 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDK97776.1 - 0.008 16.5 0.0 0.023 15.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CDK97776.1 - 0.027 14.2 0.1 0.086 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain oligo_HPY PF08352.12 CDK97776.1 - 0.033 14.7 0.0 0.081 13.4 0.0 1.7 1 0 0 1 1 1 0 Oligopeptide/dipeptide transporter, C-terminal region AAA PF00004.29 CDK97776.1 - 0.063 13.7 0.1 1.6 9.2 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDK97776.1 - 0.065 13.8 0.0 0.2 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDK97776.1 - 0.067 13.3 0.0 0.13 12.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CDK97776.1 - 0.083 13.2 0.3 2.4 8.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 CDK97776.1 - 0.12 12.3 0.0 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PRK PF00485.18 CDK97776.1 - 0.15 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ATPase_2 PF01637.18 CDK97776.1 - 0.17 11.8 0.0 0.69 9.8 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea PhoU PF01895.19 CDK97777.1 - 7.2e-43 145.0 7.7 3.7e-21 75.4 0.5 2.1 2 0 0 2 2 2 2 PhoU domain PhoU_div PF01865.16 CDK97777.1 - 4.9e-05 22.7 1.5 0.055 12.8 0.2 2.2 2 0 0 2 2 2 2 Protein of unknown function DUF47 DUF489 PF04356.12 CDK97777.1 - 0.079 13.0 0.3 0.74 9.8 0.1 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF489) Asp_Glu_race PF01177.22 CDK97777.1 - 0.099 12.5 0.1 0.55 10.0 0.0 1.9 2 0 0 2 2 2 0 Asp/Glu/Hydantoin racemase Response_reg PF00072.24 CDK97778.1 - 3.3e-31 107.8 0.0 4.7e-31 107.3 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK97778.1 - 8.9e-28 96.2 0.0 3.4e-27 94.3 0.0 1.9 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal GerE PF00196.19 CDK97778.1 - 0.13 11.8 0.0 0.43 10.2 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Guanylate_kin PF00625.21 CDK97779.1 - 3e-07 30.3 0.0 3.8e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.6 CDK97779.1 - 3.7e-06 27.5 0.0 3.5e-05 24.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDK97779.1 - 0.00012 22.3 0.9 0.00094 19.4 0.9 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDK97779.1 - 0.06 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain SepF PF04472.12 CDK97779.1 - 0.11 12.8 0.1 0.68 10.3 0.0 2.1 1 1 1 2 2 2 0 Cell division protein SepF Zeta_toxin PF06414.12 CDK97779.1 - 0.11 11.7 0.5 9.6 5.4 0.1 2.1 2 0 0 2 2 2 0 Zeta toxin ParD_antitoxin PF03693.14 CDK97780.1 - 1.7e-08 34.7 0.0 2.2e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH aGPT-Pplase3 PF18746.1 CDK97780.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 14-3-3 PF00244.20 CDK97780.1 - 0.16 11.5 0.0 0.18 11.2 0.0 1.1 1 0 0 1 1 1 0 14-3-3 protein Response_reg PF00072.24 CDK97784.1 - 0.00013 22.1 0.0 0.00016 21.8 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain HTH_3 PF01381.22 CDK97787.1 - 8.6e-08 32.1 0.1 1.4e-07 31.5 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CDK97787.1 - 9.6e-08 32.3 2.3 1.6e-07 31.6 2.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDK97787.1 - 0.00027 20.6 0.2 0.00059 19.6 0.2 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_19 PF12844.7 CDK97787.1 - 0.0014 18.6 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 CDK97787.1 - 0.002 17.8 0.0 0.0036 16.9 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 CDK97787.1 - 0.0056 16.2 0.1 0.014 14.9 0.1 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 MarR PF01047.22 CDK97787.1 - 0.0091 15.9 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 1 MarR family TnsD PF15978.5 CDK97787.1 - 0.02 13.9 0.0 0.049 12.6 0.0 1.5 1 1 1 2 2 2 0 Tn7-like transposition protein D HTH_28 PF13518.6 CDK97787.1 - 0.049 13.8 0.1 0.12 12.6 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.7 CDK97787.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 CDK97787.1 - 0.12 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding EamA PF00892.20 CDK97788.1 - 6.7e-19 68.4 44.5 2.2e-10 40.9 16.7 2.0 2 0 0 2 2 2 2 EamA-like transporter family GerE PF00196.19 CDK97789.1 - 4.2e-18 64.6 0.6 4.8e-18 64.4 0.6 1.1 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDK97789.1 - 0.00023 20.8 0.0 0.00029 20.4 0.0 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_10 PF04967.12 CDK97789.1 - 0.00069 19.4 0.1 0.00069 19.4 0.1 1.7 2 0 0 2 2 2 1 HTH DNA binding domain HTH_40 PF14493.6 CDK97789.1 - 0.006 17.0 0.1 0.0064 16.9 0.1 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDK97789.1 - 0.011 15.5 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4 PF04545.16 CDK97789.1 - 0.012 15.2 0.0 0.018 14.6 0.0 1.4 1 1 0 1 1 1 0 Sigma-70, region 4 DUF134 PF02001.16 CDK97789.1 - 0.046 14.3 0.1 0.05 14.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF134 Myosin_N PF02736.19 CDK97789.1 - 0.058 13.2 0.0 0.081 12.8 0.0 1.2 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain Titin_Z PF09042.11 CDK97789.1 - 0.6 10.1 4.3 0.62 10.1 3.6 1.5 1 1 0 1 1 1 0 Titin Z DUF4915 PF16261.5 CDK97790.1 - 2.2e-118 395.1 0.0 2.7e-118 394.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4915) DUF4347 PF14252.6 CDK97791.1 - 3.1e-45 154.0 0.0 6.3e-45 153.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) Cadherin_3 PF16184.5 CDK97791.1 - 2e-15 56.8 11.0 1.6e-12 47.4 0.0 5.4 5 1 0 5 5 5 3 Cadherin-like He_PIG PF05345.12 CDK97791.1 - 5.1e-14 52.2 13.9 3.3e-10 40.0 10.0 11.8 10 3 1 11 11 11 2 Putative Ig domain Cadherin PF00028.17 CDK97791.1 - 3.1e-09 37.2 1.7 3.1e-09 37.2 1.7 6.3 6 0 0 6 6 6 1 Cadherin domain Cpn10 PF00166.21 CDK97791.1 - 8.2e-06 25.8 5.1 0.66 10.1 0.0 5.2 4 0 0 4 4 4 3 Chaperonin 10 Kd subunit Cadherin_5 PF17892.1 CDK97791.1 - 5.8e-05 23.0 3.5 5.8e-05 23.0 3.5 12.0 8 4 4 12 12 12 3 Cadherin-like domain Big_9 PF17963.1 CDK97791.1 - 0.055 14.2 240.0 0.045 14.5 12.9 14.5 13 2 0 13 13 13 0 Bacterial Ig domain OEP PF02321.18 CDK97792.1 - 5.3e-24 85.1 28.0 1.1e-16 61.2 9.6 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein HAUS2 PF15003.6 CDK97792.1 - 0.018 14.8 0.6 0.047 13.4 0.6 1.7 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 TPR_7 PF13176.6 CDK97792.1 - 1.1 9.5 5.3 0.83 9.8 0.2 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat HlyD_3 PF13437.6 CDK97793.1 - 9.5e-16 58.4 0.3 2.3e-14 54.0 0.1 2.4 2 1 0 2 2 2 1 HlyD family secretion protein HlyD_D23 PF16576.5 CDK97793.1 - 7.7e-14 51.4 0.2 1.5e-13 50.5 0.2 1.4 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK97793.1 - 1.1e-08 34.7 0.0 0.004 16.9 0.1 2.6 2 0 0 2 2 2 2 Biotin-lipoyl like RNA_pol_I_A49 PF06870.12 CDK97793.1 - 0.022 13.6 0.2 1.8 7.3 0.0 2.1 1 1 1 2 2 2 0 A49-like RNA polymerase I associated factor Biotin_lipoyl PF00364.22 CDK97793.1 - 0.054 13.3 0.0 2.3 8.1 0.0 2.7 3 0 0 3 3 3 0 Biotin-requiring enzyme rve PF00665.26 CDK97795.1 - 1.7e-10 41.1 0.0 2e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Integrase core domain Sigma70_r4 PF04545.16 CDK97796.1 - 1.4e-18 66.2 2.5 1.2e-17 63.1 2.5 2.3 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 CDK97796.1 - 1.7e-17 63.0 0.7 5.6e-16 58.1 0.0 2.7 3 0 0 3 3 3 1 Sigma-70 region 2 Sigma70_r1_2 PF00140.20 CDK97796.1 - 1.4e-08 34.6 3.9 1.6e-07 31.2 0.5 2.5 2 0 0 2 2 2 1 Sigma-70 factor, region 1.2 LysM PF01476.20 CDK97796.1 - 0.0011 19.0 0.0 0.1 12.7 0.0 2.6 2 0 0 2 2 2 1 LysM domain Sigma70_r3 PF04539.16 CDK97796.1 - 0.0012 18.9 1.3 0.038 14.1 0.2 2.4 2 0 0 2 2 2 1 Sigma-70 region 3 UCR_14kD PF02271.16 CDK97796.1 - 0.019 14.9 0.4 0.072 13.1 0.0 2.3 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex 14kD subunit HTH_23 PF13384.6 CDK97796.1 - 0.04 13.7 0.1 2.7 7.9 0.0 3.1 3 0 0 3 3 3 0 Homeodomain-like domain HTH_11 PF08279.12 CDK97796.1 - 0.055 13.4 0.7 0.15 12.0 0.5 1.9 2 0 0 2 2 2 0 HTH domain TrmB PF01978.19 CDK97796.1 - 0.092 12.6 0.1 19 5.2 0.0 2.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB PseudoU_synth_2 PF00849.22 CDK97797.1 - 2.8e-35 121.8 0.0 3.8e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CDK97797.1 - 3.5e-06 26.6 0.0 6.6e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 S4 domain Prok-JAB PF14464.6 CDK97799.1 - 1.2e-18 66.9 0.0 1.5e-18 66.7 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain JAB PF01398.21 CDK97799.1 - 1.3e-05 25.1 0.0 2.1e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease HTH_Tnp_1 PF01527.20 CDK97800.1 - 3.2e-23 81.8 0.5 4.1e-23 81.5 0.5 1.1 1 0 0 1 1 1 1 Transposase HTH_28 PF13518.6 CDK97800.1 - 6.8e-07 29.3 0.0 1.3e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDK97800.1 - 1e-05 25.1 0.9 5.2e-05 22.9 0.2 2.4 1 1 2 3 3 3 1 Homeodomain-like domain HTH_7 PF02796.15 CDK97800.1 - 6.8e-05 22.9 0.2 0.0011 19.0 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_Tnp_1_2 PF13022.6 CDK97800.1 - 0.00045 20.4 0.5 0.0024 18.0 0.3 1.8 1 1 1 2 2 2 1 Helix-turn-helix of insertion element transposase HTH_29 PF13551.6 CDK97800.1 - 0.00054 19.9 0.1 0.0017 18.3 0.0 2.1 1 1 1 2 2 2 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 CDK97800.1 - 0.12 11.8 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Transposase_mut PF00872.18 CDK97801.1 - 1.4e-122 409.3 0.1 1.6e-122 409.1 0.1 1.0 1 0 0 1 1 1 1 Transposase, Mutator family MULE PF10551.9 CDK97801.1 - 1.5e-07 31.7 0.0 2.7e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.17 CDK97801.1 - 0.023 14.4 0.0 0.69 9.6 0.0 2.1 1 1 1 2 2 2 0 Transposase Creatininase PF02633.14 CDK97801.1 - 0.025 14.0 0.0 0.045 13.2 0.0 1.4 1 0 0 1 1 1 0 Creatinine amidohydrolase Transposase_20 PF02371.16 CDK97802.1 - 1.4e-25 89.4 0.4 2.5e-25 88.6 0.4 1.4 1 0 0 1 1 1 1 Transposase IS116/IS110/IS902 family DUF3618 PF12277.8 CDK97802.1 - 0.00031 20.9 0.8 0.015 15.5 0.1 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3618) DUF1515 PF07439.11 CDK97802.1 - 0.019 15.0 0.1 0.076 13.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) Cep57_MT_bd PF06657.13 CDK97802.1 - 0.15 12.5 0.0 0.74 10.3 0.0 1.9 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Dicistro_VP4 PF11492.8 CDK97802.1 - 0.17 11.9 0.1 0.17 11.9 0.1 1.9 2 0 0 2 2 2 0 Cricket paralysis virus, VP4 DEDD_Tnp_IS110 PF01548.17 CDK97803.1 - 6.1e-16 58.7 0.0 8.4e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 Transposase Glyco_transf_4 PF13439.6 CDK97803.1 - 0.11 12.4 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 ATPgrasp_ST PF14397.6 CDK97805.1 - 1.5e-12 47.4 0.0 2.2e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 CDK97805.1 - 0.00087 19.4 0.0 0.49 10.4 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_YheCD PF14398.6 CDK97805.1 - 0.0039 16.5 0.0 0.006 15.9 0.0 1.2 1 0 0 1 1 1 1 YheC/D like ATP-grasp rve_3 PF13683.6 CDK97807.1 - 9.3e-15 54.2 0.3 1.3e-14 53.7 0.3 1.2 1 0 0 1 1 1 1 Integrase core domain rve PF00665.26 CDK97807.1 - 5.6e-05 23.3 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain B12-binding PF02310.19 CDK97808.1 - 3.6e-25 88.3 0.1 7.9e-25 87.2 0.1 1.6 1 0 0 1 1 1 1 B12 binding domain Radical_SAM PF04055.21 CDK97808.1 - 9.4e-14 52.1 0.1 4e-13 50.1 0.1 2.1 2 1 0 2 2 2 1 Radical SAM superfamily ABC_tran PF00005.27 CDK97810.1 - 1.4e-27 96.9 0.0 2.4e-27 96.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDK97810.1 - 1e-10 41.7 11.5 1.4e-10 41.3 11.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDK97810.1 - 5.1e-09 35.9 0.0 4e-06 26.4 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDK97810.1 - 1e-05 26.0 0.6 3.6e-05 24.2 0.6 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDK97810.1 - 2.1e-05 24.2 0.3 5.6e-05 22.8 0.3 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDK97810.1 - 0.002 18.4 1.3 0.46 10.8 0.1 2.5 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CDK97810.1 - 0.0051 16.7 1.4 0.0099 15.8 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase Pex26 PF07163.12 CDK97810.1 - 0.0099 15.2 0.2 0.016 14.5 0.2 1.2 1 0 0 1 1 1 1 Pex26 protein AAA_25 PF13481.6 CDK97810.1 - 0.01 15.4 1.4 0.017 14.7 0.4 1.9 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDK97810.1 - 0.018 15.4 0.0 0.038 14.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 CDK97810.1 - 0.019 14.7 1.8 0.028 14.2 0.0 2.2 2 2 0 2 2 2 0 AAA domain AAA_21 PF13304.6 CDK97810.1 - 0.087 12.6 2.6 0.66 9.7 0.1 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDK97810.1 - 0.095 13.2 0.1 0.16 12.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 CDK97810.1 - 0.11 12.2 0.0 0.29 10.9 0.0 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase SbcCD_C PF13558.6 CDK97810.1 - 0.17 12.1 0.1 1.6 9.0 0.1 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SLATT_1 PF18181.1 CDK97810.1 - 9.4 6.2 16.7 1.5 8.8 1.1 3.4 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 Metallophos PF00149.28 CDK97811.1 - 2.9e-12 47.5 0.0 6.1e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Poly_export PF02563.16 CDK97812.1 - 3e-15 56.2 0.5 1.1e-14 54.4 0.0 2.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis/export protein SLBB PF10531.9 CDK97812.1 - 6.5e-09 35.5 0.0 1.3e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 SLBB domain Epimerase PF01370.21 CDK97813.1 - 6.2e-43 147.0 0.0 9.7e-43 146.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDK97813.1 - 3.8e-36 125.2 0.0 9.9e-36 123.8 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CDK97813.1 - 1.3e-18 67.1 0.0 1.2e-17 64.0 0.0 2.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDK97813.1 - 3.2e-17 62.6 0.0 3.9e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CDK97813.1 - 5.5e-14 51.8 0.0 7.4e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CDK97813.1 - 2e-07 30.5 0.4 0.00064 19.0 0.0 2.7 2 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CDK97813.1 - 1.3e-05 25.2 0.0 1.9e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CDK97813.1 - 0.015 15.5 0.2 0.3 11.4 0.0 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 CDK97813.1 - 0.067 12.6 0.3 7.7 5.9 0.0 2.4 2 1 0 2 2 2 0 short chain dehydrogenase Semialdhyde_dh PF01118.24 CDK97813.1 - 0.16 12.4 0.3 1.2 9.6 0.2 2.1 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Pectate_lyase_3 PF12708.7 CDK97814.1 - 2e-15 57.2 3.9 2.6e-12 47.0 0.0 2.9 2 1 1 3 3 3 2 Pectate lyase superfamily protein Beta_helix PF13229.6 CDK97814.1 - 1.3e-14 54.4 8.5 2.8e-08 33.8 2.8 2.6 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.13 CDK97814.1 - 0.0017 17.7 5.3 0.033 13.4 5.7 2.4 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) Glyco_tran_WecB PF03808.13 CDK97815.1 - 8.7e-49 165.7 0.1 1.4e-48 165.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase WecB/TagA/CpsF family Methyltransf_23 PF13489.6 CDK97815.1 - 6.5e-13 48.8 0.0 1.3e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK97815.1 - 1.7e-05 25.5 0.0 4.6e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDK97815.1 - 8.1e-05 22.5 0.0 0.00022 21.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK97815.1 - 0.0001 22.9 0.0 0.0019 18.8 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK97815.1 - 0.023 15.4 0.0 0.12 13.0 0.0 2.3 3 0 0 3 3 3 0 Methyltransferase domain Bac_transf PF02397.16 CDK97816.1 - 4.8e-58 195.8 0.0 6.7e-58 195.3 0.0 1.2 1 0 0 1 1 1 1 Bacterial sugar transferase CoA_binding_3 PF13727.6 CDK97816.1 - 0.00014 22.0 0.7 0.00026 21.0 0.7 1.4 1 0 0 1 1 1 1 CoA-binding domain TylF PF05711.11 CDK97819.1 - 1.3e-16 60.6 0.0 2.4e-12 46.7 0.0 2.1 2 0 0 2 2 2 2 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 CDK97819.1 - 0.00017 22.6 0.0 0.00035 21.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDK97820.1 - 4.9e-13 49.2 0.0 6.8e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK97820.1 - 3.8e-07 30.8 0.1 1.9e-06 28.5 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK97820.1 - 5.3e-07 30.2 0.0 1.1e-06 29.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDK97820.1 - 0.00017 21.4 0.0 0.00024 20.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK97820.1 - 0.004 17.8 0.1 0.012 16.3 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain BBP2_2 PF10082.9 CDK97821.1 - 1.6e-86 290.6 7.1 1.8e-86 290.3 7.1 1.0 1 0 0 1 1 1 1 Putative beta-barrel porin 2 OMP_b-brl PF13505.6 CDK97821.1 - 0.00051 20.2 3.0 0.023 14.8 0.0 2.9 1 1 1 2 2 2 1 Outer membrane protein beta-barrel domain DUF481 PF04338.12 CDK97821.1 - 0.046 13.7 6.2 0.3 11.1 0.7 3.0 2 2 1 3 3 3 0 Protein of unknown function, DUF481 DUF560 PF04575.13 CDK97821.1 - 0.099 12.1 0.1 2.2 7.6 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF560) AAA_31 PF13614.6 CDK97822.1 - 4.5e-11 43.0 0.0 3.2e-10 40.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain GNVR PF13807.6 CDK97822.1 - 9.2e-10 38.3 0.2 5.1e-09 35.9 0.0 2.3 2 0 0 2 2 2 1 G-rich domain on putative tyrosine kinase Wzz PF02706.15 CDK97822.1 - 1.9e-06 28.1 0.5 6.1e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 Chain length determinant protein CbiA PF01656.23 CDK97822.1 - 3.2e-06 27.2 0.0 1.4e-05 25.1 0.0 2.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 CDK97822.1 - 0.00017 21.2 1.1 0.0029 17.1 1.1 2.3 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 CDK97822.1 - 0.00071 19.1 0.0 0.0016 18.0 0.0 1.5 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Goodbye PF17109.5 CDK97822.1 - 0.26 11.7 1.4 4.8 7.7 0.1 2.8 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain FapA PF03961.13 CDK97822.1 - 0.64 8.6 5.5 0.14 10.7 0.9 1.8 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF4404 PF14357.6 CDK97822.1 - 2.2 9.0 6.6 3.5 8.3 0.5 3.5 3 1 2 5 5 5 0 Domain of unknown function (DUF4404) Syntaxin-6_N PF09177.11 CDK97822.1 - 3.4 8.3 7.7 12 6.5 0.7 3.0 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Wzy_C PF04932.15 CDK97824.1 - 5.3e-13 48.9 1.0 5.3e-13 48.9 1.0 3.5 3 1 0 3 3 3 1 O-Antigen ligase Epimerase_2 PF02350.19 CDK97825.1 - 4.4e-103 344.8 0.1 5.1e-103 344.6 0.1 1.0 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase Glyco_trans_4_4 PF13579.6 CDK97825.1 - 8.3e-06 26.3 4.8 8.3e-06 26.3 4.8 2.1 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CDK97825.1 - 0.00032 20.8 2.5 0.0005 20.1 0.4 2.0 2 0 0 2 2 2 1 Glycosyltransferase Family 4 DUF5519 PF17648.1 CDK97825.1 - 0.043 13.7 1.0 0.095 12.6 1.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5519) Asn_synthase PF00733.21 CDK97826.1 - 4.5e-51 174.6 0.2 5.8e-51 174.2 0.2 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CDK97826.1 - 2.7e-38 130.7 0.0 4.1e-38 130.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDK97826.1 - 5.2e-30 104.4 0.0 9.3e-30 103.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain NTP_transf_5 PF14907.6 CDK97829.1 - 3.5e-47 161.2 4.8 3.5e-47 161.2 4.8 1.6 2 0 0 2 2 2 1 Uncharacterised nucleotidyltransferase Glycos_transf_1 PF00534.20 CDK97829.1 - 5.1e-19 68.5 0.0 8.4e-19 67.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDK97829.1 - 1.2e-16 61.2 7.4 1.4e-15 57.7 3.1 3.3 2 2 1 3 3 3 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CDK97829.1 - 3.2e-15 56.7 0.1 6.1e-15 55.8 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDK97829.1 - 1.6e-14 54.7 8.2 1.6e-14 54.7 8.2 4.7 3 3 0 3 3 3 1 Glycosyl transferase 4-like domain PIGA PF08288.12 CDK97829.1 - 0.0076 16.8 0.0 0.016 15.8 0.0 1.5 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_5 PF08323.11 CDK97829.1 - 0.0088 15.8 0.2 0.39 10.4 0.0 2.3 1 1 0 2 2 2 1 Starch synthase catalytic domain Asn_synthase PF00733.21 CDK97831.1 - 6.3e-28 98.4 0.0 9.7e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CDK97831.1 - 9.5e-20 70.7 0.0 1.5e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDK97831.1 - 1.1e-18 67.7 0.1 2.2e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain NAD_synthase PF02540.17 CDK97831.1 - 0.075 12.1 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 NAD synthase PqqD PF05402.12 CDK97832.1 - 1.1e-16 60.8 0.0 1.4e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) Lant_dehydr_N PF04738.13 CDK97832.1 - 0.0064 14.6 0.0 0.0079 14.3 0.0 1.1 1 0 0 1 1 1 1 Lantibiotic dehydratase, N terminus Hpr_kinase_C PF07475.12 CDK97833.1 - 8.2e-06 25.4 0.0 4.2e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 HPr Serine kinase C-terminal domain AAA_16 PF13191.6 CDK97833.1 - 0.00067 20.1 0.0 0.001 19.5 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain PEPCK_ATP PF01293.20 CDK97833.1 - 0.0011 17.8 0.1 0.0015 17.3 0.1 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase CoaE PF01121.20 CDK97833.1 - 0.003 17.3 0.0 0.0047 16.6 0.0 1.3 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 CDK97833.1 - 0.0033 17.6 0.0 0.0069 16.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDK97833.1 - 0.0041 17.4 0.0 0.0073 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDK97833.1 - 0.0056 16.4 0.1 0.011 15.5 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain IIGP PF05049.13 CDK97833.1 - 0.0076 15.4 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 CDK97833.1 - 0.015 15.8 0.0 0.024 15.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 CDK97833.1 - 0.023 14.9 0.0 0.038 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDK97833.1 - 0.028 13.8 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 KaiC IstB_IS21 PF01695.17 CDK97833.1 - 0.076 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RsgA_GTPase PF03193.16 CDK97833.1 - 0.093 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 CDK97833.1 - 0.18 10.9 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Sulfotransfer_1 PF00685.27 CDK97834.1 - 4.2e-23 82.2 0.0 4.7e-22 78.7 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CDK97834.1 - 2.6e-07 31.3 0.0 0.00025 21.5 0.0 2.6 2 1 0 2 2 2 2 Sulfotransferase family Hexapep_loop PF18776.1 CDK97835.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Hexapeptide repeat including loop Transglut_core3 PF13471.6 CDK97836.1 - 8.4e-23 80.5 1.8 1.1e-22 80.1 1.8 1.2 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_core PF01841.19 CDK97836.1 - 0.1 13.0 4.2 0.33 11.4 4.1 1.7 1 1 0 1 1 1 0 Transglutaminase-like superfamily 2OG-FeII_Oxy_3 PF13640.6 CDK97837.1 - 2.1e-15 57.3 0.0 3.4e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 CDK97837.1 - 1.7e-08 35.0 0.0 2.7e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 CDK97837.1 - 0.00083 19.7 0.0 0.0015 18.9 0.0 1.5 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase DDE_Tnp_1 PF01609.21 CDK97838.1 - 1e-10 41.7 1.6 5.7e-08 32.7 0.0 2.0 1 1 1 2 2 2 2 Transposase DDE domain DDE_Tnp_1_2 PF13586.6 CDK97838.1 - 8.2e-10 38.9 0.0 1.1e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_3 PF13612.6 CDK97838.1 - 2e-05 24.7 0.0 2.5e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_4 PF13359.6 CDK97838.1 - 0.14 11.8 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF4096 PF13340.6 CDK97839.1 - 4e-26 91.0 1.8 5.5e-26 90.6 1.8 1.2 1 0 0 1 1 1 1 Putative transposase of IS4/5 family (DUF4096) DUF4096 PF13340.6 CDK97840.1 - 1.2e-23 83.1 2.5 1.2e-23 83.1 2.5 1.6 2 0 0 2 2 2 1 Putative transposase of IS4/5 family (DUF4096) DDE_Tnp_1_2 PF13586.6 CDK97841.1 - 1.4e-23 83.1 0.0 1.7e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1 PF01609.21 CDK97841.1 - 2.6e-14 53.4 0.2 3.1e-12 46.6 0.2 2.0 1 1 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_3 PF13612.6 CDK97841.1 - 5.5e-06 26.5 0.0 7e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Transposase DDE domain IMS PF00817.20 CDK97843.1 - 7.7e-06 26.0 0.0 1.1e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 impB/mucB/samB family PemK_toxin PF02452.17 CDK97847.1 - 1.9e-07 31.4 0.0 2e-07 31.4 0.0 1.0 1 0 0 1 1 1 1 PemK-like, MazF-like toxin of type II toxin-antitoxin system Ion_trans PF00520.31 CDK97849.1 - 0.062 12.5 3.5 0.072 12.3 3.5 1.2 1 0 0 1 1 1 0 Ion transport protein DUF677 PF05055.12 CDK97849.1 - 0.3 9.9 0.4 0.4 9.5 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF677) HTH_31 PF13560.6 CDK97850.1 - 3.1e-16 59.4 0.0 3.8e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 CDK97850.1 - 4.6e-14 52.2 0.0 6e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 CDK97850.1 - 2.6e-08 33.7 0.0 3.5e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 CDK97850.1 - 3.4e-05 23.6 0.0 4.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 CDK97850.1 - 0.026 14.5 0.0 0.031 14.2 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_26 PF13443.6 CDK97850.1 - 0.03 14.7 0.0 0.045 14.2 0.0 1.2 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain MqsA_antitoxin PF15731.5 CDK97850.1 - 0.089 12.9 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_3 PF01381.22 CDK97851.1 - 7.1e-13 48.4 0.1 8.7e-13 48.1 0.1 1.1 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 CDK97851.1 - 2e-11 43.7 0.0 2.5e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 CDK97851.1 - 7.9e-11 42.1 0.8 9.5e-11 41.9 0.8 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 CDK97851.1 - 0.00021 21.6 0.0 0.00026 21.4 0.0 1.1 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_37 PF13744.6 CDK97851.1 - 0.0017 18.3 0.0 0.0021 18.0 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain KorB PF08535.10 CDK97851.1 - 0.0025 17.8 0.0 0.0055 16.7 0.0 1.6 1 1 1 2 2 2 1 KorB domain HTH_25 PF13413.6 CDK97851.1 - 0.0073 16.1 0.1 0.18 11.7 0.1 2.1 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 CDK97851.1 - 0.05 13.2 0.0 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding MtrG PF04210.13 CDK97851.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.6 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G MqsA_antitoxin PF15731.5 CDK97851.1 - 0.13 12.4 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA Pou PF00157.17 CDK97851.1 - 0.14 12.1 0.1 0.21 11.6 0.1 1.4 1 1 0 1 1 1 0 Pou domain - N-terminal to homeobox domain Relaxase PF03432.14 CDK97852.1 - 0.024 14.3 0.0 0.035 13.7 0.0 1.2 1 0 0 1 1 1 0 Relaxase/Mobilisation nuclease domain ParE_toxin PF05016.15 CDK97853.1 - 0.0048 17.5 0.0 0.0056 17.3 0.0 1.3 1 0 0 1 1 1 1 ParE toxin of type II toxin-antitoxin system, parDE 3-alpha PF03475.14 CDK97853.1 - 0.023 14.6 0.3 0.051 13.4 0.3 1.7 1 0 0 1 1 1 0 3-alpha domain GGDEF_2 PF17853.1 CDK97853.1 - 0.093 13.0 0.8 0.19 12.0 0.4 1.7 1 1 1 2 2 2 0 GGDEF-like domain Phage_integrase PF00589.22 CDK97854.1 - 3.2e-28 98.7 0.2 6.9e-27 94.3 0.0 2.2 2 0 0 2 2 2 1 Phage integrase family Phage_int_SAM_3 PF14659.6 CDK97854.1 - 4.4e-06 26.9 0.0 8.7e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_5 PF13102.6 CDK97854.1 - 0.042 14.2 0.0 0.1 12.9 0.0 1.6 1 1 0 1 1 1 0 Phage integrase SAM-like domain Phage_integr_3 PF16795.5 CDK97854.1 - 0.079 12.9 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Archaeal phage integrase Phage_integrase PF00589.22 CDK97855.1 - 1.7e-39 135.3 0.3 2.5e-39 134.8 0.3 1.2 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_4 PF13495.6 CDK97855.1 - 1.3e-15 57.6 0.0 3.8e-15 56.1 0.0 1.8 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 CDK97855.1 - 1.7e-10 41.0 0.3 8.6e-10 38.8 0.1 2.3 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_integr_3 PF16795.5 CDK97855.1 - 0.081 12.8 0.1 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 Archaeal phage integrase Y2_Tnp PF04986.13 CDK97856.1 - 1.2e-62 211.3 0.2 1.6e-62 210.9 0.2 1.2 1 0 0 1 1 1 1 Putative transposase Zn_Tnp_IS91 PF14319.6 CDK97856.1 - 1.9e-31 107.9 0.8 1.9e-31 107.9 0.8 2.1 2 0 0 2 2 2 1 Transposase zinc-binding domain zf-IS66 PF13005.7 CDK97856.1 - 0.083 13.3 9.2 1.9 9.0 0.6 4.3 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 Anti-TRAP PF15777.5 CDK97856.1 - 3.3 7.8 8.3 9.1 6.3 0.2 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Rep_1 PF01446.17 CDK97856.1 - 4.7 6.6 6.4 0.52 9.7 0.5 2.2 3 0 0 3 3 3 0 Replication protein OrfB_Zn_ribbon PF07282.11 CDK97856.1 - 5.8 6.9 8.4 37 4.4 0.1 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain HypA PF01155.19 CDK97856.1 - 9.4 6.3 6.4 5.6 7.0 2.1 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA cNMP_binding PF00027.29 CDK97857.1 - 2.7e-16 59.4 0.0 4e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain AraC_binding_2 PF14525.6 CDK97857.1 - 0.0044 16.7 0.1 0.0092 15.7 0.0 1.6 1 1 1 2 2 2 1 AraC-binding-like domain ABC_tran PF00005.27 CDK97858.1 - 4.3e-30 105.0 0.0 7.1e-30 104.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDK97858.1 - 1.1e-18 67.9 12.9 1.5e-18 67.4 12.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_22 PF13401.6 CDK97858.1 - 5.1e-07 30.0 0.0 1e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDK97858.1 - 3.8e-05 24.1 0.6 0.00013 22.4 0.1 2.1 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 CDK97858.1 - 7e-05 22.4 0.0 0.055 12.9 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDK97858.1 - 0.0036 17.2 0.0 0.0067 16.3 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 CDK97858.1 - 0.023 14.5 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CDK97858.1 - 0.036 14.0 0.1 0.068 13.1 0.1 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 CDK97858.1 - 0.074 12.8 0.5 0.18 11.5 0.5 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CDK97858.1 - 0.079 13.0 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.22 CDK97858.1 - 0.089 12.0 0.1 0.16 11.1 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_33 PF13671.6 CDK97858.1 - 0.11 12.6 2.2 0.19 11.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 CDK97858.1 - 0.13 12.8 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDK97858.1 - 0.18 12.2 0.0 0.31 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA helicase YtpI PF14007.6 CDK97858.1 - 2.9 8.1 10.8 0.32 11.2 1.9 2.6 2 1 0 2 2 2 0 YtpI-like protein Peptidase_C39 PF03412.15 CDK97859.1 - 1.8e-38 131.3 0.0 2.9e-38 130.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase C39 family ABC_tran PF00005.27 CDK97859.1 - 3.7e-29 102.0 0.0 6.1e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDK97859.1 - 7.2e-23 81.6 9.4 8.9e-23 81.3 9.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region Peptidase_C70 PF12385.8 CDK97859.1 - 0.00025 21.1 0.0 0.00085 19.3 0.0 1.8 1 1 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 Peptidase_C39_2 PF13529.6 CDK97859.1 - 0.0011 19.5 0.1 1.7 9.2 0.0 2.3 2 0 0 2 2 2 2 Peptidase_C39 like family SMC_N PF02463.19 CDK97859.1 - 0.0015 18.0 0.0 0.045 13.2 0.0 1.9 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDK97859.1 - 0.079 12.7 0.4 0.18 11.6 0.4 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 CDK97859.1 - 0.13 12.5 0.5 2.6 8.3 0.5 2.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDK97859.1 - 0.16 12.2 0.0 0.4 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDK97859.1 - 0.2 11.3 1.5 1.4 8.6 1.5 2.2 1 1 0 1 1 1 0 AAA domain HlyD_3 PF13437.6 CDK97860.1 - 2.9e-13 50.4 1.5 1.6e-08 35.2 0.0 2.5 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDK97860.1 - 6.8e-13 48.2 4.8 2.8e-09 36.7 0.3 3.1 3 0 0 3 3 3 2 Biotin-lipoyl like HlyD_D23 PF16576.5 CDK97860.1 - 6.7e-10 38.5 5.1 8.4e-06 25.2 0.0 2.3 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl PF00364.22 CDK97860.1 - 2.8e-05 23.9 4.4 0.048 13.5 0.1 3.8 5 0 0 5 5 5 2 Biotin-requiring enzyme Methyltransf_28 PF02636.17 CDK97860.1 - 0.12 12.0 0.8 0.22 11.1 0.8 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Invasin_D3 PF09134.10 CDK97861.1 - 0.26 11.6 0.7 1 9.7 0.7 1.8 1 1 0 1 1 1 0 Invasin, domain 3 DUF772 PF05598.11 CDK97862.1 - 1.6e-26 92.1 0.1 3.5e-26 91.0 0.1 1.6 1 0 0 1 1 1 1 Transposase domain (DUF772) DDE_Tnp_1_6 PF13751.6 CDK97862.1 - 1.5e-18 67.2 0.2 2.8e-18 66.4 0.2 1.4 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1 PF01609.21 CDK97862.1 - 2.6e-15 56.7 0.0 1.6e-14 54.1 0.0 2.0 1 1 0 1 1 1 1 Transposase DDE domain Resolvase PF00239.21 CDK97864.1 - 1e-38 132.7 0.0 1.8e-38 131.9 0.0 1.4 1 0 0 1 1 1 1 Resolvase, N terminal domain Recombinase PF07508.13 CDK97864.1 - 5.7e-13 49.2 0.0 1.2e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 Recombinase Zn_ribbon_recom PF13408.6 CDK97864.1 - 4.3e-05 23.9 0.0 0.00011 22.7 0.0 1.7 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain DUF2924 PF11149.8 CDK97865.1 - 5.2e-54 182.3 0.0 5.8e-54 182.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2924) RAMA PF18755.1 CDK97865.1 - 0.0064 16.9 0.1 0.012 16.0 0.0 1.5 2 0 0 2 2 2 1 Restriction Enzyme Adenine Methylase Associated CheR_N PF03705.15 CDK97865.1 - 0.089 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 CheR methyltransferase, all-alpha domain HTH_31 PF13560.6 CDK97867.1 - 0.00025 21.3 0.2 0.1 12.9 0.1 2.3 1 1 1 2 2 2 2 Helix-turn-helix domain HTH_3 PF01381.22 CDK97867.1 - 0.0057 16.7 0.0 0.25 11.4 0.0 2.6 1 1 0 2 2 2 1 Helix-turn-helix P22_Cro PF14549.6 CDK97867.1 - 0.015 15.1 0.1 0.027 14.3 0.1 1.4 1 0 0 1 1 1 0 DNA-binding transcriptional regulator Cro DUF1580 PF07618.11 CDK97867.1 - 0.023 14.3 0.3 0.2 11.3 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1580) YdaS_antitoxin PF15943.5 CDK97867.1 - 0.031 14.1 0.2 0.045 13.6 0.2 1.5 1 1 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_Tnp_ISL3 PF13542.6 CDK97867.1 - 0.08 12.4 0.2 0.15 11.5 0.2 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Peripla_BP_3 PF13377.6 CDK97867.1 - 0.089 13.1 0.1 0.096 13.0 0.1 1.1 1 0 0 1 1 1 0 Periplasmic binding protein-like domain Recombinase PF07508.13 CDK97868.1 - 4e-22 78.6 0.5 6.4e-22 77.9 0.1 1.6 2 0 0 2 2 2 1 Recombinase Resolvase PF00239.21 CDK97868.1 - 1.1e-20 74.3 0.7 2.7e-20 73.0 0.2 1.9 2 0 0 2 2 2 1 Resolvase, N terminal domain RepB PF07506.11 CDK97869.1 - 2.4e-15 57.1 0.2 3.4e-15 56.6 0.2 1.2 1 0 0 1 1 1 1 RepB plasmid partitioning protein ParBc PF02195.18 CDK97869.1 - 7e-14 51.9 0.2 2.6e-13 50.1 0.1 2.0 2 0 0 2 2 2 1 ParB-like nuclease domain MarR_2 PF12802.7 CDK97869.1 - 0.012 15.5 0.0 0.038 13.9 0.0 1.9 1 0 0 1 1 1 0 MarR family HTH_3 PF01381.22 CDK97869.1 - 0.041 13.9 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix RepB PF07506.11 CDK97870.1 - 1.9e-36 125.9 3.2 1.9e-36 125.9 3.2 1.4 2 0 0 2 2 2 1 RepB plasmid partitioning protein ParBc PF02195.18 CDK97870.1 - 1.1e-08 35.3 0.1 5.3e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 ParB-like nuclease domain DUF3131 PF11329.8 CDK97870.1 - 0.03 13.4 0.0 0.047 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3131) Hemagglutinin PF00509.18 CDK97870.1 - 0.23 9.8 0.0 0.33 9.3 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin Rep_fac-A_C PF08646.10 CDK97871.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Replication factor-A C terminal domain DUF3040 PF11239.8 CDK97871.1 - 0.56 10.5 6.4 8 6.8 5.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) Phage-tail_3 PF13550.6 CDK97873.1 - 2.3e-24 86.1 0.0 5.1e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 Putative phage tail protein Lambda_tail_I PF06805.12 CDK97873.1 - 5.4e-11 42.7 0.5 1.7e-10 41.1 0.5 1.9 1 0 0 1 1 1 1 Bacteriophage lambda tail assembly protein I NLPC_P60 PF00877.19 CDK97874.1 - 1.7e-06 28.0 0.0 2e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 NlpC/P60 family DUF1833 PF08875.11 CDK97875.1 - 2.7e-63 212.0 0.1 3.1e-63 211.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1833) DUF736 PF05284.12 CDK97875.1 - 0.016 15.1 0.0 0.3 11.0 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF736) DUF3379 PF11859.8 CDK97876.1 - 0.003 16.9 0.4 0.0034 16.7 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3379) YebO PF13974.6 CDK97876.1 - 0.0081 16.2 0.1 0.011 15.8 0.1 1.2 1 0 0 1 1 1 1 YebO-like protein DUF2570 PF10828.8 CDK97876.1 - 0.075 12.9 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) Radical_SAM PF04055.21 CDK97877.1 - 1.7e-06 28.6 0.0 3.6e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CDK97877.1 - 0.00018 21.8 0.0 0.00036 20.8 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CDK97877.1 - 0.00074 19.6 0.6 0.0019 18.3 0.0 2.0 2 1 0 2 2 2 1 4Fe-4S single cluster domain AbrB-like PF14250.6 CDK97878.1 - 0.032 14.3 0.0 0.08 13.0 0.0 1.6 2 0 0 2 2 2 0 AbrB-like transcriptional regulator Tape_meas_lam_C PF09718.10 CDK97881.1 - 1.2e-20 73.4 2.6 1.2e-20 73.4 2.6 3.1 3 0 0 3 3 3 1 Lambda phage tail tape-measure protein (Tape_meas_lam_C) SHOCT PF09851.9 CDK97881.1 - 0.0019 17.9 5.9 0.0056 16.4 3.8 3.0 2 0 0 2 2 2 1 Short C-terminal domain GvpG PF05120.12 CDK97881.1 - 0.83 9.7 7.7 0.25 11.4 1.1 3.3 3 0 0 3 3 3 0 Gas vesicle protein G LMBR1 PF04791.16 CDK97881.1 - 7.2 5.4 7.6 3.9 6.3 0.1 2.2 2 0 0 2 2 2 0 LMBR1-like membrane protein RelB PF04221.12 CDK97886.1 - 4.9e-16 58.5 0.0 5.1e-16 58.4 0.0 1.0 1 0 0 1 1 1 1 RelB antitoxin DUF99 PF01949.16 CDK97886.1 - 0.16 11.3 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF99 YafQ_toxin PF15738.5 CDK97887.1 - 4.9e-32 110.1 0.0 5.3e-32 110.0 0.0 1.0 1 0 0 1 1 1 1 Bacterial toxin of type II toxin-antitoxin system, YafQ TrkA_C PF02080.21 CDK97889.1 - 0.012 15.5 0.2 0.019 14.8 0.2 1.4 1 1 0 1 1 1 0 TrkA-C domain HicB-like_2 PF15970.5 CDK97889.1 - 0.14 12.3 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 HicB_like antitoxin of bacterial toxin-antitoxin system Phage_cap_E PF03864.15 CDK97890.1 - 8.2e-94 314.5 0.3 9.6e-94 314.3 0.3 1.0 1 0 0 1 1 1 1 Phage major capsid protein E HDPD PF02924.14 CDK97891.1 - 2.9e-30 104.7 1.9 3.3e-30 104.6 1.9 1.0 1 0 0 1 1 1 1 Bacteriophage lambda head decoration protein D Peptidase_S49 PF01343.18 CDK97892.1 - 3.4e-29 101.8 0.0 5.7e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S49 CLP_protease PF00574.23 CDK97892.1 - 0.1 12.5 0.1 0.55 10.1 0.0 2.0 2 0 0 2 2 2 0 Clp protease PhdYeFM_antitox PF02604.19 CDK97893.1 - 1.2e-15 57.0 0.0 1.5e-15 56.7 0.0 1.2 1 1 0 1 1 1 1 Antitoxin Phd_YefM, type II toxin-antitoxin system PHD_like PF12910.7 CDK97893.1 - 0.051 13.6 0.0 0.067 13.2 0.0 1.1 1 0 0 1 1 1 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system PIN PF01850.21 CDK97894.1 - 3.1e-15 56.8 0.0 3.7e-15 56.5 0.0 1.0 1 0 0 1 1 1 1 PIN domain DUF4411 PF14367.6 CDK97894.1 - 0.0015 18.4 0.0 0.0044 16.9 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4411) DUF5615 PF18480.1 CDK97894.1 - 0.12 12.2 0.0 0.41 10.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5615) Phage_portal_2 PF05136.13 CDK97895.1 - 1.5e-110 369.8 0.0 2.2e-110 369.3 0.0 1.3 1 0 0 1 1 1 1 Phage portal protein, lambda family DUF3847 PF12958.7 CDK97896.1 - 0.022 14.9 0.4 0.045 13.9 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) PspA_IM30 PF04012.12 CDK97896.1 - 0.038 13.6 0.1 0.041 13.5 0.1 1.0 1 0 0 1 1 1 0 PspA/IM30 family Terminase_GpA PF05876.12 CDK97897.1 - 6.8e-209 695.0 0.8 7.9e-209 694.8 0.8 1.0 1 0 0 1 1 1 1 Phage terminase large subunit (GpA) DUF3268 PF11672.8 CDK97897.1 - 0.0032 17.8 0.1 0.01 16.2 0.2 1.8 2 0 0 2 2 2 1 zinc-finger-containing domain Lar_restr_allev PF14354.6 CDK97897.1 - 0.024 15.0 0.7 0.049 14.0 0.7 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar Prim_Zn_Ribbon PF08273.12 CDK97897.1 - 0.047 14.0 1.4 0.12 12.7 1.4 1.7 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase DUF3489 PF11994.8 CDK97900.1 - 2.5e-33 113.9 1.2 3e-33 113.7 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3489) DpnD-PcfM PF14207.6 CDK97901.1 - 0.071 13.0 0.3 0.099 12.5 0.3 1.4 1 0 0 1 1 1 0 DpnD/PcfM-like protein AGTRAP PF06396.11 CDK97903.1 - 0.083 12.7 0.4 0.091 12.6 0.4 1.0 1 0 0 1 1 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) POTRA_TamA_1 PF17243.2 CDK97904.1 - 0.052 13.7 0.2 0.064 13.4 0.2 1.1 1 0 0 1 1 1 0 POTRA domain TamA domain 1 N6_N4_Mtase PF01555.18 CDK97906.1 - 4.1e-14 52.8 0.6 2.2e-12 47.2 0.6 2.6 1 1 0 1 1 1 1 DNA methylase ParBc PF02195.18 CDK97906.1 - 3.3e-11 43.3 0.0 9.9e-11 41.8 0.0 1.7 1 0 0 1 1 1 1 ParB-like nuclease domain Met_10 PF02475.16 CDK97906.1 - 0.14 11.9 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein DNA_methylase PF00145.17 CDK97907.1 - 1.8e-41 142.6 0.0 1.3e-22 80.6 0.0 2.9 3 0 0 3 3 3 3 C-5 cytosine-specific DNA methylase He_PIG PF05345.12 CDK97910.1 - 1.8e-07 31.2 0.3 1.8e-07 31.2 0.3 1.9 2 0 0 2 2 2 1 Putative Ig domain Big_9 PF17963.1 CDK97910.1 - 0.011 16.5 1.4 0.02 15.6 1.4 1.5 1 0 0 1 1 1 0 Bacterial Ig domain OEP PF02321.18 CDK97911.1 - 3.7e-28 98.6 28.8 1.1e-17 64.5 10.8 2.2 2 0 0 2 2 2 2 Outer membrane efflux protein Amidase PF01425.21 CDK97911.1 - 0.029 13.3 0.6 0.062 12.2 0.4 1.7 1 1 1 2 2 2 0 Amidase HAUS2 PF15003.6 CDK97911.1 - 0.046 13.5 1.7 0.077 12.7 0.5 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 DUF1542 PF07564.11 CDK97911.1 - 0.065 13.3 0.2 68 3.7 0.0 3.5 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1542) DDE_Tnp_1_4 PF13701.6 CDK97912.1 - 4.4e-12 45.0 0.4 5.3e-12 44.7 0.4 1.0 1 0 0 1 1 1 1 Transposase DDE domain group 1 DDE_Tnp_1 PF01609.21 CDK97912.1 - 0.0059 16.3 0.3 0.0072 16.0 0.3 1.1 1 0 0 1 1 1 1 Transposase DDE domain DUF4347 PF14252.6 CDK97913.1 - 7e-50 169.1 1.0 7e-50 169.1 1.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4347) SBBP PF06739.11 CDK97913.1 - 2e-20 72.5 61.2 2.3e-05 24.3 3.4 7.4 7 0 0 7 7 7 5 Beta-propeller repeat He_PIG PF05345.12 CDK97913.1 - 1.1e-06 28.7 0.2 1.1e-06 28.7 0.2 7.9 8 0 0 8 8 8 1 Putative Ig domain SCAB-Ig PF16709.5 CDK97913.1 - 0.057 13.5 0.1 0.16 12.0 0.1 1.8 1 0 0 1 1 1 0 Ig domain of plant-specific actin-binding protein RHS PF03527.14 CDK97913.1 - 1.2 9.0 12.3 14 5.6 0.0 6.0 6 0 0 6 6 6 0 RHS protein CAP_N PF01213.19 CDK97913.1 - 1.4 8.3 6.2 2.8 7.4 6.2 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DEC-1_N PF04625.13 CDK97913.1 - 8.3 5.3 18.1 15 4.4 18.1 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region OEP PF02321.18 CDK97914.1 - 1.2e-26 93.7 28.3 8.2e-17 61.6 10.3 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein HAUS2 PF15003.6 CDK97914.1 - 0.015 15.1 1.2 0.03 14.0 0.4 1.9 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 HlyD_3 PF13437.6 CDK97915.1 - 2.4e-15 57.1 1.3 1.9e-13 51.0 0.1 2.9 1 1 2 3 3 3 1 HlyD family secretion protein HlyD_D23 PF16576.5 CDK97915.1 - 6.6e-14 51.6 0.1 9.9e-14 51.1 0.1 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK97915.1 - 1.3e-11 44.1 0.1 6.2e-06 26.0 0.0 2.5 2 0 0 2 2 2 2 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK97915.1 - 0.012 15.4 0.0 4.9 7.0 0.0 2.5 2 0 0 2 2 2 0 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 CDK97915.1 - 0.1 12.4 0.1 5.1 6.9 0.0 2.5 2 1 1 3 3 3 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 HlyD_3 PF13437.6 CDK97917.1 - 9.4e-13 48.8 4.4 1.3e-08 35.5 0.3 2.4 1 1 1 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDK97917.1 - 4.2e-07 29.7 1.3 4.2e-07 29.7 1.3 2.6 3 1 0 3 3 3 1 Biotin-lipoyl like HlyD_D23 PF16576.5 CDK97917.1 - 8.7e-06 25.1 1.0 1.3e-05 24.5 1.0 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl PF00364.22 CDK97917.1 - 0.024 14.4 0.0 0.058 13.2 0.0 1.6 1 0 0 1 1 1 0 Biotin-requiring enzyme Phage_CI_repr PF07022.13 CDK97917.1 - 0.1 12.7 0.0 0.23 11.6 0.0 1.6 1 1 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain LOB PF03195.14 CDK97917.1 - 0.2 12.3 0.3 23 5.6 0.2 2.3 2 0 0 2 2 2 0 Lateral organ boundaries (LOB) domain Biotin_lipoyl_2 PF13533.6 CDK97918.1 - 6.6e-09 35.5 0.0 1.5e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Biotin-lipoyl like HlyD_3 PF13437.6 CDK97918.1 - 1.9e-06 28.5 0.1 0.00099 19.8 0.0 2.5 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl PF00364.22 CDK97918.1 - 0.019 14.8 0.0 0.05 13.4 0.0 1.7 2 0 0 2 2 2 0 Biotin-requiring enzyme Peptidase_M50 PF02163.22 CDK97918.1 - 0.25 10.6 12.1 8.2 5.6 12.1 2.7 1 1 0 1 1 1 0 Peptidase family M50 T2SSM PF04612.12 CDK97918.1 - 0.32 11.1 2.0 0.66 10.0 0.1 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M HipA_C PF07804.12 CDK97920.1 - 1.6e-18 67.2 0.0 2.1e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 HipA-like C-terminal domain CotH PF08757.11 CDK97920.1 - 0.071 12.6 0.1 0.11 12.0 0.0 1.2 1 1 0 1 1 1 0 CotH kinase protein RACo_C_ter PF14574.6 CDK97920.1 - 0.089 11.8 0.1 0.11 11.5 0.1 1.1 1 0 0 1 1 1 0 C-terminal domain of RACo the ASKHA domain Death PF00531.22 CDK97920.1 - 0.098 12.8 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Death domain PLDc_2 PF13091.6 CDK97921.1 - 3.3e-26 91.7 0.6 4.2e-26 91.4 0.6 1.1 1 0 0 1 1 1 1 PLD-like domain FAM83 PF07894.12 CDK97921.1 - 5.9e-07 29.3 0.1 4.1e-06 26.5 0.1 2.1 1 1 0 1 1 1 1 FAM83 A-H PLDc PF00614.22 CDK97921.1 - 0.0017 18.5 0.0 0.0051 16.9 0.0 1.9 1 0 0 1 1 1 1 Phospholipase D Active site motif Regulator_TrmB PF11495.8 CDK97921.1 - 0.0041 16.3 0.7 0.0051 16.0 0.7 1.2 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB F_bP_aldolase PF01116.20 CDK97921.1 - 0.22 11.0 2.0 0.28 10.6 2.0 1.1 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II DDE_3 PF13358.6 CDK97922.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK97922.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDK97923.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK97923.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK97923.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK97923.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK97923.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK97923.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DUF697 PF05128.12 CDK97924.1 - 2.2e-29 102.2 1.1 4.1e-29 101.4 1.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF697) DUF463 PF04317.12 CDK97925.1 - 1.3e-129 433.0 0.0 1.5e-129 432.8 0.0 1.0 1 0 0 1 1 1 1 YcjX-like family, DUF463 AAA_14 PF13173.6 CDK97925.1 - 0.0035 17.4 0.0 0.014 15.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 CDK97925.1 - 0.09 12.1 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family Peptidase_S24 PF00717.23 CDK97927.1 - 1.5e-05 24.9 0.1 2.7e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Peptidase S24-like HTH_17 PF12728.7 CDK97928.1 - 0.0002 21.4 0.3 0.00028 21.0 0.3 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDK97928.1 - 0.039 13.8 0.1 0.06 13.2 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Phage_connect_1 PF05135.13 CDK97930.1 - 7.9e-06 26.3 0.0 0.00024 21.6 0.0 2.2 2 0 0 2 2 2 1 Phage gp6-like head-tail connector protein Mem_trans PF03547.18 CDK97931.1 - 2.5e-11 42.6 15.3 1.9e-06 26.6 5.7 2.0 1 1 1 2 2 2 2 Membrane transport protein SBF PF01758.16 CDK97931.1 - 0.076 12.7 11.2 0.027 14.2 4.6 2.6 2 1 0 2 2 2 0 Sodium Bile acid symporter family DUF4147 PF13660.6 CDK97932.1 - 1.6e-76 256.9 0.5 2.8e-76 256.1 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.13 CDK97932.1 - 3.8e-37 126.8 3.3 8.5e-37 125.7 3.3 1.6 1 0 0 1 1 1 1 MOFRL family DHDPS PF00701.22 CDK97933.1 - 1.4e-38 132.2 0.0 1.7e-38 132.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family MFS_1 PF07690.16 CDK97934.1 - 7.3e-51 173.1 54.9 7.3e-51 173.1 54.9 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_3 PF05977.13 CDK97934.1 - 3.7e-10 38.8 15.3 3.7e-10 38.8 15.3 2.8 2 1 0 2 2 2 1 Transmembrane secretion effector MFS_1_like PF12832.7 CDK97934.1 - 5.1e-05 22.3 10.0 0.0026 16.7 7.2 2.4 2 1 0 2 2 2 2 MFS_1 like family OATP PF03137.20 CDK97934.1 - 0.0023 16.3 3.0 0.0023 16.3 3.0 2.7 2 2 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family Phage_holin_Dp1 PF16938.5 CDK97934.1 - 2.4 8.4 6.0 1.8 8.8 0.3 3.8 3 0 0 3 3 3 0 Putative phage holin Dp-1 Saf_2TM PF18303.1 CDK97934.1 - 3.7 7.1 5.5 0.43 10.2 0.2 2.2 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain LysR_substrate PF03466.20 CDK97935.1 - 4.4e-23 81.7 7.3 4.4e-23 81.7 7.3 1.6 1 1 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDK97935.1 - 5.3e-15 55.1 1.4 1.6e-14 53.6 1.4 1.9 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR_2 PF12802.7 CDK97935.1 - 0.00062 19.6 0.6 0.0034 17.2 0.3 2.4 2 0 0 2 2 2 1 MarR family HTH_30 PF13556.6 CDK97935.1 - 0.0021 17.8 0.3 0.0061 16.3 0.1 1.9 2 0 0 2 2 2 1 PucR C-terminal helix-turn-helix domain HTH_29 PF13551.6 CDK97935.1 - 0.028 14.5 2.2 0.13 12.3 0.2 2.7 2 1 1 3 3 3 0 Winged helix-turn helix HTH_28 PF13518.6 CDK97935.1 - 0.041 14.0 2.0 0.089 12.9 0.1 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_8 PF02954.19 CDK97935.1 - 0.16 11.8 1.3 0.33 10.8 0.3 2.0 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family Radical_SAM PF04055.21 CDK97936.1 - 6.2e-17 62.5 0.0 1.3e-16 61.4 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily SPASM PF13186.6 CDK97936.1 - 5e-11 42.9 1.6 1.3e-10 41.6 1.6 1.7 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain TPR_16 PF13432.6 CDK97936.1 - 2.5e-08 34.4 4.6 2.5e-08 34.4 4.6 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDK97936.1 - 1.2e-05 25.0 12.6 0.0092 16.0 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat Fer4_14 PF13394.6 CDK97936.1 - 2.6e-05 24.3 0.1 4.8e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain TPR_14 PF13428.6 CDK97936.1 - 3.9e-05 24.1 20.7 0.68 10.9 0.6 4.8 2 1 3 5 5 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDK97936.1 - 5.4e-05 23.6 15.0 0.00053 20.4 1.1 3.4 1 1 4 5 5 5 4 Tetratricopeptide repeat Fer4_12 PF13353.6 CDK97936.1 - 0.0003 21.1 0.1 0.00077 19.7 0.1 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain ANAPC3 PF12895.7 CDK97936.1 - 0.0097 16.1 1.1 0.21 11.8 0.1 2.7 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CDK97936.1 - 0.035 14.4 14.8 0.036 14.4 2.1 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat Smr PF01713.21 CDK97936.1 - 0.05 14.0 0.0 0.21 11.9 0.0 2.0 1 0 0 1 1 1 0 Smr domain Hydrolase PF00702.26 CDK97936.1 - 0.098 12.9 0.0 0.22 11.8 0.0 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase TPR_8 PF13181.6 CDK97936.1 - 0.94 9.9 3.9 12 6.4 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDK97936.1 - 1.8 8.8 5.5 0.67 10.1 0.9 2.3 2 1 1 3 3 3 0 Tetratricopeptide repeat YfdX PF10938.8 CDK97936.1 - 3.9 7.4 9.0 7.4 6.5 0.4 3.2 3 0 0 3 3 3 0 YfdX protein HATPase_c PF02518.26 CDK97937.1 - 9.1e-32 109.9 0.0 2.6e-31 108.4 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK97937.1 - 7.5e-31 106.6 0.0 5.7e-24 84.4 0.0 3.0 2 0 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 CDK97937.1 - 7.9e-22 77.1 5.1 6.7e-19 67.7 0.2 3.9 3 0 0 3 3 3 2 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 CDK97937.1 - 2.4e-08 34.2 0.0 6.9e-08 32.7 0.0 1.9 1 0 0 1 1 1 1 PAS domain HAMP PF00672.25 CDK97937.1 - 5.8e-08 33.0 0.1 5.8e-08 33.0 0.1 3.9 4 0 0 4 4 3 1 HAMP domain PAS_8 PF13188.7 CDK97937.1 - 4.7e-07 29.7 0.1 3.4e-06 26.9 0.0 2.5 2 0 0 2 2 2 1 PAS domain Hpt PF01627.23 CDK97937.1 - 8.4e-07 29.2 3.4 8.4e-07 29.2 3.4 3.6 3 0 0 3 3 3 1 Hpt domain PAS_3 PF08447.12 CDK97937.1 - 3.1e-06 27.4 0.0 6e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDK97937.1 - 0.00091 19.5 1.1 0.013 15.7 0.0 3.1 3 0 0 3 3 3 1 PAS fold 4HB_MCP_1 PF12729.7 CDK97937.1 - 0.022 14.3 0.0 0.37 10.3 0.0 2.3 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction PAS PF00989.25 CDK97937.1 - 0.046 13.7 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 PAS fold DUF2730 PF10805.8 CDK97937.1 - 1.1 9.4 3.7 0.6 10.2 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) Response_reg PF00072.24 CDK97939.1 - 4.7e-26 91.2 0.1 5.4e-26 91.0 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain POR PF01558.18 CDK97940.1 - 7.5e-40 136.9 0.1 8.9e-40 136.6 0.1 1.0 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase Arm-DNA-bind_1 PF09003.10 CDK97940.1 - 0.075 13.2 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 Bacteriophage lambda integrase, Arm DNA-binding domain TPP_enzyme_C PF02775.21 CDK97941.1 - 7e-27 94.1 0.0 1.6e-26 93.0 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain POR_N PF01855.19 CDK97941.1 - 1.9e-16 60.5 0.2 3e-16 59.9 0.2 1.3 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Fer4_7 PF12838.7 CDK97941.1 - 8.6e-05 23.0 9.4 0.00031 21.3 9.4 2.0 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDK97941.1 - 0.00017 21.7 8.1 0.00017 21.7 8.1 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain DXP_synthase_N PF13292.6 CDK97941.1 - 0.0007 18.9 0.1 0.0015 17.8 0.1 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Fer4 PF00037.27 CDK97941.1 - 0.0018 18.0 11.1 0.0029 17.3 2.8 2.9 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_10 PF13237.6 CDK97941.1 - 0.002 18.2 9.9 0.002 18.2 9.9 2.1 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDK97941.1 - 0.0044 17.1 10.5 0.29 11.3 1.4 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain TPP_enzyme_N PF02776.18 CDK97941.1 - 0.01 15.5 0.2 0.02 14.5 0.2 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Fer4_2 PF12797.7 CDK97941.1 - 0.017 15.2 23.5 0.031 14.4 2.8 3.1 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_8 PF13183.6 CDK97941.1 - 0.028 14.9 7.1 0.089 13.2 7.1 1.9 1 0 0 1 1 1 0 4Fe-4S dicluster domain AWPM-19 PF05512.11 CDK97941.1 - 0.11 12.7 0.4 0.2 11.8 0.4 1.3 1 0 0 1 1 1 0 AWPM-19-like family Fer4_16 PF13484.6 CDK97941.1 - 0.15 13.0 5.6 1.5 9.8 0.7 2.9 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain Fer4_6 PF12837.7 CDK97941.1 - 0.56 10.4 17.4 0.4 10.8 2.0 2.9 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_15 PF13459.6 CDK97941.1 - 8.6 7.2 7.2 2.3 9.0 0.7 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain AMP-binding_C_2 PF14535.6 CDK97943.1 - 9.9e-26 89.9 0.0 2e-25 88.9 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 CDK97943.1 - 6.8e-13 48.0 1.0 7.1e-13 47.9 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme GH3 PF03321.13 CDK97943.1 - 0.12 11.2 0.0 0.52 9.1 0.0 1.9 3 0 0 3 3 3 0 GH3 auxin-responsive promoter Autoind_bind PF03472.15 CDK97944.1 - 2.2e-36 124.6 0.9 3.3e-36 124.0 0.9 1.3 1 0 0 1 1 1 1 Autoinducer binding domain GerE PF00196.19 CDK97944.1 - 1.8e-07 30.6 0.0 3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Aldedh PF00171.22 CDK97945.1 - 3.2e-174 579.8 0.6 3.6e-174 579.6 0.6 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Abhydrolase_6 PF12697.7 CDK97946.1 - 8.6e-19 69.0 0.4 1.1e-18 68.7 0.4 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDK97946.1 - 7.8e-17 61.8 0.0 1.4e-16 61.0 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDK97946.1 - 2.6e-08 33.4 0.0 3.5e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 CheB_methylest PF01339.17 CDK97947.1 - 2.6e-56 190.0 0.1 5.6e-56 188.9 0.1 1.6 1 0 0 1 1 1 1 CheB methylesterase CheR PF01739.18 CDK97947.1 - 4.1e-54 183.1 0.0 7.8e-54 182.1 0.0 1.5 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain HATPase_c PF02518.26 CDK97947.1 - 1.9e-23 83.1 0.0 5e-23 81.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 CDK97947.1 - 2.1e-23 82.6 0.0 7.5e-18 64.7 0.0 3.6 4 0 0 4 4 2 2 PAS domain PAS_4 PF08448.10 CDK97947.1 - 4.3e-20 72.0 0.1 1.1e-07 32.1 0.0 4.3 4 0 0 4 4 3 3 PAS fold PAS_10 PF13596.6 CDK97947.1 - 7.1e-20 71.6 0.1 1.9e-18 67.0 0.0 3.1 3 0 0 3 3 2 1 PAS domain PAS PF00989.25 CDK97947.1 - 2.2e-12 47.0 0.1 4.9e-09 36.2 0.0 4.2 4 0 0 4 4 3 1 PAS fold CheR_N PF03705.15 CDK97947.1 - 6.5e-10 38.6 1.1 2.2e-09 36.9 0.1 2.2 2 0 0 2 2 2 1 CheR methyltransferase, all-alpha domain PAS_8 PF13188.7 CDK97947.1 - 7.3e-09 35.5 0.1 3.2e-07 30.2 0.0 3.6 4 1 0 4 4 2 1 PAS domain HisKA PF00512.25 CDK97947.1 - 2.2e-08 34.0 0.5 2.2e-08 34.0 0.5 2.7 4 0 0 4 4 1 1 His Kinase A (phospho-acceptor) domain PAS_7 PF12860.7 CDK97947.1 - 7.1e-08 32.6 0.0 0.022 14.9 0.0 4.5 3 1 0 3 3 3 2 PAS fold PAS_3 PF08447.12 CDK97947.1 - 2.6e-07 30.8 0.2 1.3e-06 28.6 0.2 2.4 2 0 0 2 2 1 1 PAS fold HATPase_c_5 PF14501.6 CDK97947.1 - 1.1e-05 25.3 0.0 3.1e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 GHKL domain CENP-F_leu_zip PF10473.9 CDK97947.1 - 2.8e-05 24.2 15.9 6.1e-05 23.1 15.9 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 CDK97947.1 - 0.00055 19.3 7.8 0.0014 17.9 7.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Snapin_Pallidin PF14712.6 CDK97947.1 - 0.0017 18.7 5.7 0.0072 16.7 5.7 2.2 1 0 0 1 1 1 1 Snapin/Pallidin NRBF2 PF08961.10 CDK97947.1 - 0.0092 15.6 3.8 0.017 14.7 3.8 1.3 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator UPF0449 PF15136.6 CDK97947.1 - 0.013 15.9 6.2 0.04 14.4 6.2 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 HAUS-augmin3 PF14932.6 CDK97947.1 - 0.014 15.0 5.4 0.026 14.1 5.4 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Methyltransf_12 PF08242.12 CDK97947.1 - 0.018 15.7 0.1 0.82 10.5 0.0 3.3 2 1 0 2 2 2 0 Methyltransferase domain OmpH PF03938.14 CDK97947.1 - 0.02 15.2 5.7 0.015 15.6 3.2 2.0 2 0 0 2 2 1 0 Outer membrane protein (OmpH-like) IFT57 PF10498.9 CDK97947.1 - 0.034 13.1 9.2 0.057 12.4 9.2 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Mod_r PF07200.13 CDK97947.1 - 0.037 14.1 10.2 0.097 12.8 10.2 1.6 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein KASH_CCD PF14662.6 CDK97947.1 - 0.073 12.9 11.8 0.16 11.8 11.8 1.5 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH TMF_TATA_bd PF12325.8 CDK97947.1 - 0.082 13.1 15.4 0.2 11.9 15.4 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding KxDL PF10241.9 CDK97947.1 - 0.1 12.9 9.1 0.079 13.2 6.1 2.4 2 0 0 2 2 1 0 Uncharacterized conserved protein Exonuc_VII_L PF02601.15 CDK97947.1 - 0.11 12.0 0.3 0.29 10.7 0.3 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.11 CDK97947.1 - 0.13 11.1 13.8 0.23 10.3 13.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF812 PF05667.11 CDK97947.1 - 0.14 11.0 5.2 0.25 10.2 3.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF812) UPF0242 PF06785.11 CDK97947.1 - 0.17 12.0 4.5 0.33 11.0 4.5 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Golgin_A5 PF09787.9 CDK97947.1 - 0.18 11.3 11.0 0.35 10.3 11.0 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 APG6_N PF17675.1 CDK97947.1 - 0.18 12.3 13.9 0.028 14.9 9.8 1.7 2 0 0 2 2 1 0 Apg6 coiled-coil region DUF4201 PF13870.6 CDK97947.1 - 0.21 11.3 7.9 0.29 10.9 7.1 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF4201) Med30 PF11315.8 CDK97947.1 - 0.24 11.6 6.2 0.48 10.6 6.2 1.5 1 0 0 1 1 1 0 Mediator complex subunit 30 DUF3584 PF12128.8 CDK97947.1 - 0.24 8.9 9.3 0.39 8.2 9.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) bZIP_1 PF00170.21 CDK97947.1 - 0.28 11.3 9.4 0.65 10.1 4.7 2.6 2 0 0 2 2 2 0 bZIP transcription factor DUF16 PF01519.16 CDK97947.1 - 0.59 10.7 7.5 1.8 9.1 7.5 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF16 EzrA PF06160.12 CDK97947.1 - 0.71 8.0 10.3 1.1 7.3 10.3 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA HMMR_N PF15905.5 CDK97947.1 - 0.86 9.0 17.0 0.19 11.2 12.3 1.9 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Mt_ATP-synt_B PF05405.14 CDK97947.1 - 1.3 8.6 10.1 3.1 7.4 10.1 1.5 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) TMPIT PF07851.13 CDK97947.1 - 1.6 7.9 4.1 2.7 7.2 4.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein KELK PF15796.5 CDK97947.1 - 1.7 9.2 13.0 0.23 11.9 8.9 1.8 2 0 0 2 2 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase HOOK PF05622.12 CDK97947.1 - 1.7 6.7 11.4 3 5.9 11.4 1.3 1 0 0 1 1 1 0 HOOK protein LXG PF04740.12 CDK97947.1 - 1.8 8.2 8.2 4.7 6.9 8.2 1.7 1 0 0 1 1 1 0 LXG domain of WXG superfamily DUF2203 PF09969.9 CDK97947.1 - 2.3 9.0 3.9 6.8 7.4 3.9 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF1664 PF07889.12 CDK97947.1 - 2.7 8.0 4.7 8.3 6.5 4.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 CDK97947.1 - 3.1 7.8 9.7 3.7 7.6 1.4 1.9 1 1 1 2 2 2 0 Laminin Domain II Jnk-SapK_ap_N PF09744.9 CDK97947.1 - 5.2 7.3 14.6 3.2 8.0 12.2 1.8 2 0 0 2 2 1 0 JNK_SAPK-associated protein-1 zf-C4H2 PF10146.9 CDK97947.1 - 5.4 7.3 9.0 11 6.3 9.0 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein FapA PF03961.13 CDK97947.1 - 6 5.4 6.6 9.2 4.7 6.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Med21 PF11221.8 CDK97947.1 - 6.1 7.1 13.5 14 5.9 1.8 2.6 1 1 1 2 2 2 0 Subunit 21 of Mediator complex JIP_LZII PF16471.5 CDK97947.1 - 8.1 6.7 16.6 9 6.6 5.2 2.8 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Seryl_tRNA_N PF02403.22 CDK97947.1 - 8.4 6.7 11.7 0.95 9.7 7.2 1.8 2 0 0 2 2 1 0 Seryl-tRNA synthetase N-terminal domain Guanylate_cyc PF00211.20 CDK97948.1 - 2e-12 47.1 0.0 4.1e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain TPR_19 PF14559.6 CDK97948.1 - 0.031 14.8 6.5 0.39 11.2 0.0 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDK97948.1 - 0.36 11.1 8.1 9 6.7 1.9 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDK97948.1 - 9.9 7.3 13.7 22 6.2 0.1 5.0 3 2 2 5 5 5 0 Tetratricopeptide repeat MCPsignal PF00015.21 CDK97949.1 - 7.2e-30 104.1 48.1 1.7e-28 99.5 35.2 3.8 2 1 2 4 4 4 1 Methyl-accepting chemotaxis protein (MCP) signalling domain 4HB_MCP_1 PF12729.7 CDK97949.1 - 2.2e-25 89.3 0.0 2.2e-25 89.3 0.0 3.3 3 1 0 3 3 3 1 Four helix bundle sensory module for signal transduction TarH PF02203.15 CDK97949.1 - 4.5e-11 43.0 6.3 4.5e-11 43.0 6.3 4.6 4 2 1 5 5 2 1 Tar ligand binding domain homologue HAMP PF00672.25 CDK97949.1 - 6.9e-07 29.6 0.4 6.9e-07 29.6 0.4 4.8 5 1 0 5 5 4 1 HAMP domain T7SS_ESX_EspC PF10824.8 CDK97949.1 - 0.013 16.0 9.2 0.013 16.0 9.2 5.8 5 2 2 7 7 6 0 Excreted virulence factor EspC, type VII ESX diderm DUF148 PF02520.17 CDK97949.1 - 0.022 14.9 2.5 0.022 14.9 2.5 3.9 3 2 1 4 4 4 0 Domain of unknown function DUF148 DUF1664 PF07889.12 CDK97949.1 - 0.089 12.8 12.4 2.2 8.3 0.3 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 CDK97949.1 - 0.43 10.8 4.8 4.3 7.5 0.0 3.1 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family Spore_III_AB PF09548.10 CDK97949.1 - 0.68 10.0 5.6 2.4 8.3 1.1 3.2 3 2 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) Syntaxin_2 PF14523.6 CDK97949.1 - 0.92 9.9 8.4 22 5.5 0.1 4.4 2 1 2 4 4 4 0 Syntaxin-like protein Laminin_II PF06009.12 CDK97949.1 - 1.2 9.1 23.5 2.2 8.3 5.4 4.2 3 1 1 4 4 4 0 Laminin Domain II LOH1CR12 PF10158.9 CDK97949.1 - 1.4 9.0 5.3 4.7 7.2 0.3 3.4 3 1 0 3 3 3 0 Tumour suppressor protein NPV_P10 PF05531.12 CDK97949.1 - 6.3 7.3 11.3 0.93 10.0 0.6 4.4 3 2 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 CDK97949.1 - 9.4 6.6 33.8 50 4.3 1.3 7.0 3 2 4 7 7 7 0 Bacterial protein of unknown function (DUF948) SpoU_methylase PF00588.19 CDK97950.1 - 1.5e-27 96.5 0.0 2.1e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family TPR_16 PF13432.6 CDK97951.1 - 0.021 15.4 2.0 0.047 14.3 2.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Nucleopor_Nup85 PF07575.13 CDK97951.1 - 0.058 12.0 0.0 0.073 11.6 0.0 1.1 1 0 0 1 1 1 0 Nup85 Nucleoporin TPR_14 PF13428.6 CDK97951.1 - 0.11 13.3 1.3 0.22 12.5 0.5 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat CAP_N PF01213.19 CDK97951.1 - 2 7.8 3.9 2.9 7.3 3.9 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal HMGL-like PF00682.19 CDK97952.1 - 6.5e-42 143.9 0.0 1.2e-41 143.1 0.0 1.4 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 CDK97952.1 - 3.2e-28 98.3 0.0 6e-28 97.4 0.0 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain DUF218 PF02698.17 CDK97953.1 - 2.4e-31 108.5 0.1 2.8e-31 108.3 0.1 1.1 1 0 0 1 1 1 1 DUF218 domain Methyltransf_11 PF08241.12 CDK97954.1 - 1.5e-23 83.2 0.1 3.6e-23 82.0 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK97954.1 - 1.9e-22 79.8 0.4 8.8e-22 77.6 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDK97954.1 - 1.1e-17 64.4 0.0 1.3e-17 64.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDK97954.1 - 6.1e-16 58.6 0.0 1e-15 57.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK97954.1 - 1.7e-15 57.5 0.1 5.9e-15 55.8 0.0 1.9 2 1 1 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDK97954.1 - 4.2e-10 39.4 0.0 7.2e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 CDK97954.1 - 4e-09 36.6 0.0 1.1e-08 35.2 0.0 1.6 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 CDK97954.1 - 2.2e-08 33.8 0.1 1e-07 31.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain CMAS PF02353.20 CDK97954.1 - 1.4e-07 31.1 0.0 2.8e-07 30.1 0.0 1.4 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 CDK97954.1 - 2.7e-06 27.4 0.0 4.9e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CDK97954.1 - 3.3e-06 26.3 0.0 3.3e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.12 CDK97954.1 - 5.7e-06 26.0 0.0 1e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW DUF938 PF06080.12 CDK97954.1 - 0.00032 20.5 0.0 0.0052 16.6 0.0 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF938) PrmA PF06325.13 CDK97954.1 - 0.00049 19.6 0.0 0.00077 18.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TPMT PF05724.11 CDK97954.1 - 0.005 16.5 0.4 0.016 14.9 0.1 1.9 3 0 0 3 3 2 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_4 PF02390.17 CDK97954.1 - 0.012 15.1 0.0 0.53 9.7 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_18 PF12847.7 CDK97954.1 - 0.029 14.3 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.13 CDK97954.1 - 0.034 14.5 0.0 0.056 13.8 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase FtsJ PF01728.19 CDK97954.1 - 0.039 14.1 0.0 0.14 12.3 0.0 1.8 1 1 0 1 1 1 0 FtsJ-like methyltransferase N6_N4_Mtase PF01555.18 CDK97954.1 - 0.058 13.1 0.0 1 9.0 0.0 2.1 2 0 0 2 2 2 0 DNA methylase TehB PF03848.14 CDK97954.1 - 0.078 12.4 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB RrnaAD PF00398.20 CDK97954.1 - 0.079 12.0 0.0 0.099 11.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PCMT PF01135.19 CDK97954.1 - 0.085 12.6 0.1 0.13 12.0 0.1 1.3 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MCPsignal PF00015.21 CDK97955.1 - 3.5e-31 108.3 51.6 6e-31 107.6 27.4 4.0 3 1 1 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK97955.1 - 7e-09 35.9 8.3 9.3e-09 35.5 0.1 5.1 4 1 0 4 4 4 1 HAMP domain DUF1722 PF08349.11 CDK97955.1 - 0.024 14.9 0.6 0.18 12.1 0.0 2.8 3 1 1 4 4 4 0 Protein of unknown function (DUF1722) RNA_Me_trans PF04252.13 CDK97955.1 - 0.11 12.1 1.9 0.36 10.4 0.0 2.4 2 0 0 2 2 2 0 Predicted SAM-dependent RNA methyltransferase BLOC1_2 PF10046.9 CDK97955.1 - 0.24 11.8 15.8 4 7.8 1.4 5.6 5 2 1 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SCO1-SenC PF02630.14 CDK97955.1 - 0.33 10.9 2.1 1.9 8.4 0.1 3.2 3 1 0 3 3 3 0 SCO1/SenC DUF948 PF06103.11 CDK97955.1 - 0.44 10.8 34.3 0.25 11.6 2.0 7.5 4 1 2 6 6 6 0 Bacterial protein of unknown function (DUF948) CENP-F_leu_zip PF10473.9 CDK97955.1 - 1.9 8.5 11.1 0.55 10.3 1.2 3.7 4 0 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Dynactin_p22 PF07426.11 CDK97955.1 - 2.9 7.7 8.0 1.4 8.8 0.3 3.2 3 1 0 3 3 3 0 Dynactin subunit p22 Laminin_II PF06009.12 CDK97955.1 - 4.2 7.4 24.4 0.78 9.8 6.0 4.6 3 2 1 5 5 5 0 Laminin Domain II TMPIT PF07851.13 CDK97955.1 - 8.2 5.6 5.7 13 4.9 1.1 2.8 3 0 0 3 3 3 0 TMPIT-like protein DUF1664 PF07889.12 CDK97955.1 - 9.2 6.3 23.8 4 7.5 2.7 5.0 4 2 1 5 5 5 0 Protein of unknown function (DUF1664) Lectin_N PF03954.14 CDK97955.1 - 9.5 6.0 7.4 2.1 8.1 0.4 3.1 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain DDE_3 PF13358.6 CDK97956.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK97956.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDK97957.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK97957.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK97957.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK97957.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK97957.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK97957.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain EpmC PF04315.12 CDK97959.1 - 0.0045 16.7 0.1 0.01 15.5 0.0 1.6 2 0 0 2 2 2 1 Elongation factor P hydroxylase Peptidase_M50 PF02163.22 CDK97959.1 - 0.12 11.6 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M50 DUF5343 PF17278.2 CDK97959.1 - 0.13 12.3 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5343) HycI PF01750.18 CDK97960.1 - 1.2e-08 34.8 0.0 1.3e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Hydrogenase maturation protease FecR PF04773.13 CDK97961.1 - 1.2e-08 35.5 0.2 2e-08 34.8 0.0 1.4 2 0 0 2 2 2 1 FecR protein OmpA PF00691.20 CDK97962.1 - 1.7e-18 66.8 0.0 4.1e-18 65.5 0.0 1.6 2 0 0 2 2 2 1 OmpA family HTH_3 PF01381.22 CDK97963.1 - 2.8e-12 46.5 0.1 1.5e-11 44.2 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 CDK97963.1 - 4.7e-10 39.7 0.9 9.6e-10 38.7 0.2 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 CDK97963.1 - 7e-06 26.0 0.0 1.4e-05 25.0 0.0 1.5 2 0 0 2 2 2 1 Helix-turn-helix domain Pou PF00157.17 CDK97963.1 - 0.077 13.0 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Pou domain - N-terminal to homeobox domain HTH_26 PF13443.6 CDK97963.1 - 0.12 12.8 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain SIL1 PF16782.5 CDK97963.1 - 0.17 11.1 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 YdaS_antitoxin PF15943.5 CDK97963.1 - 0.18 11.7 0.0 0.43 10.5 0.0 1.6 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_31 PF13560.6 CDK97964.1 - 1.2e-08 35.1 0.0 2.3e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 CDK97964.1 - 4.7e-08 33.0 0.0 1.2e-07 31.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_25 PF13413.6 CDK97964.1 - 0.00012 21.9 0.1 0.00033 20.5 0.2 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 CDK97964.1 - 0.003 17.5 0.0 0.0053 16.7 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Autoind_bind PF03472.15 CDK97965.1 - 1.8e-31 108.6 0.0 2.7e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 Autoinducer binding domain GerE PF00196.19 CDK97965.1 - 3.6e-18 64.8 0.1 5.3e-18 64.3 0.1 1.2 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDK97965.1 - 0.00011 21.8 0.0 0.00019 21.0 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_10 PF04967.12 CDK97965.1 - 0.0013 18.5 0.3 0.013 15.2 0.0 2.7 4 0 0 4 4 4 1 HTH DNA binding domain Sigma70_r4 PF04545.16 CDK97965.1 - 0.0025 17.3 0.0 0.0054 16.2 0.0 1.6 1 1 0 1 1 1 1 Sigma-70, region 4 Autoind_synth PF00765.17 CDK97966.1 - 8e-24 84.2 0.0 1e-23 83.8 0.0 1.1 1 0 0 1 1 1 1 Autoinducer synthase Acetyltransf_5 PF13444.6 CDK97966.1 - 0.00074 20.2 0.0 0.0012 19.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain HTH_IclR PF09339.10 CDK97967.1 - 0.019 14.7 1.4 0.57 10.0 1.4 2.1 1 1 0 1 1 1 0 IclR helix-turn-helix domain GvpL_GvpF PF06386.11 CDK97968.1 - 0.064 13.2 0.9 0.066 13.1 0.9 1.0 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF1722 PF08349.11 CDK97968.1 - 0.084 13.2 0.0 0.095 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) Radical_SAM PF04055.21 CDK97969.1 - 4.2e-13 50.0 0.0 1e-12 48.7 0.1 1.7 2 0 0 2 2 2 1 Radical SAM superfamily B12-binding PF02310.19 CDK97969.1 - 2.5e-12 46.9 0.0 1.3e-09 38.1 0.0 3.2 3 0 0 3 3 3 2 B12 binding domain SpdB PF05122.13 CDK97969.1 - 3.8 7.7 7.9 1.9 8.7 4.8 2.1 2 0 0 2 2 2 0 Mobile element transfer protein AhpC-TSA PF00578.21 CDK97971.1 - 1.9e-35 121.5 0.1 2.4e-35 121.1 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDK97971.1 - 6.7e-13 48.6 0.0 9.2e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CDK97971.1 - 1.2e-07 31.4 0.4 2.3e-07 30.6 0.1 1.7 2 0 0 2 2 2 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 CDK97971.1 - 1.5e-05 24.9 0.0 7.6e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 SCO1/SenC Pyr_redox_2 PF07992.14 CDK97972.1 - 3.4e-44 151.3 7.0 5.2e-44 150.6 7.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDK97972.1 - 1.6e-20 73.6 1.4 3.2e-17 62.7 1.4 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDK97972.1 - 9.3e-14 51.8 9.4 1.7e-12 47.7 0.4 3.3 3 1 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDK97972.1 - 6.5e-09 35.4 13.9 0.0017 17.5 0.5 3.6 3 1 1 4 4 4 3 Glucose inhibited division protein A Thioredoxin_3 PF13192.6 CDK97972.1 - 2.5e-08 33.8 0.1 1.9e-07 31.0 0.0 2.6 3 0 0 3 3 2 1 Thioredoxin domain FAD_binding_2 PF00890.24 CDK97972.1 - 1.5e-07 30.9 16.3 0.027 13.6 4.4 4.4 3 1 1 4 4 4 4 FAD binding domain HI0933_like PF03486.14 CDK97972.1 - 4.7e-06 25.6 9.3 0.11 11.2 0.4 3.4 3 0 0 3 3 3 3 HI0933-like protein NAD_binding_7 PF13241.6 CDK97972.1 - 9.6e-05 22.8 2.3 0.3 11.5 0.1 2.7 3 0 0 3 3 2 2 Putative NAD(P)-binding FAD_oxidored PF12831.7 CDK97972.1 - 0.00013 21.4 14.5 0.00065 19.2 5.3 2.9 2 1 1 3 3 3 2 FAD dependent oxidoreductase DAO PF01266.24 CDK97972.1 - 0.00017 21.3 12.7 0.12 12.0 3.3 3.5 4 0 0 4 4 4 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CDK97972.1 - 0.00099 18.4 5.3 0.0036 16.6 0.8 2.4 2 0 0 2 2 2 1 FAD binding domain K_oxygenase PF13434.6 CDK97972.1 - 0.002 17.3 1.7 0.0032 16.7 0.1 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Glutaredoxin PF00462.24 CDK97972.1 - 0.0075 16.5 5.0 0.018 15.2 0.0 3.7 5 0 0 5 5 4 1 Glutaredoxin AlaDh_PNT_C PF01262.21 CDK97972.1 - 0.015 14.6 11.7 0.16 11.3 1.4 2.7 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CDK97972.1 - 0.031 13.5 1.9 0.71 9.1 0.3 2.5 2 0 0 2 2 2 0 Thi4 family NAD_binding_8 PF13450.6 CDK97972.1 - 0.039 14.2 5.9 0.16 12.2 0.9 2.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 CDK97972.1 - 0.043 12.2 0.0 0.068 11.6 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Lycopene_cycl PF05834.12 CDK97972.1 - 0.16 11.0 5.4 14 4.6 0.0 3.1 3 0 0 3 3 3 0 Lycopene cyclase protein Trp_halogenase PF04820.14 CDK97972.1 - 1.5 7.6 6.8 3.3 6.5 0.3 2.4 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_9 PF13454.6 CDK97972.1 - 3.2 7.7 7.3 7.9 6.4 0.1 3.5 3 0 0 3 3 3 0 FAD-NAD(P)-binding ACPS PF01648.20 CDK97973.1 - 9.3e-16 58.0 0.0 2.5e-15 56.6 0.0 1.7 2 1 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily DUF2189 PF09955.9 CDK97974.1 - 2.4e-32 111.8 17.3 2.4e-32 111.8 17.3 2.5 3 0 0 3 3 3 1 Predicted integral membrane protein (DUF2189) Na_H_Exchanger PF00999.21 CDK97975.1 - 1.5e-41 142.5 49.5 2.1e-41 142.0 49.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family cNMP_binding PF00027.29 CDK97975.1 - 1.2e-17 63.8 0.0 3e-17 62.5 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 CDK97975.1 - 0.034 13.8 0.0 0.071 12.8 0.0 1.4 1 0 0 1 1 1 0 Cupin domain MarR PF01047.22 CDK97976.1 - 1.1e-15 57.2 0.0 2e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 CDK97976.1 - 8.8e-14 51.1 0.7 1.5e-13 50.4 0.7 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 CDK97976.1 - 3e-09 37.2 0.1 9e-09 35.7 0.1 1.8 1 1 1 2 2 2 1 Winged helix DNA-binding domain HTH_24 PF13412.6 CDK97976.1 - 7.8e-06 25.4 0.1 2.4e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.6 CDK97976.1 - 0.033 14.1 0.0 0.065 13.2 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain GPP34 PF05719.11 CDK97976.1 - 0.034 14.2 0.7 0.1 12.6 0.4 2.0 1 1 0 1 1 1 0 Golgi phosphoprotein 3 (GPP34) HTH_IclR PF09339.10 CDK97976.1 - 0.059 13.2 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_11 PF08279.12 CDK97976.1 - 0.087 12.8 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 HTH domain HTH_34 PF13601.6 CDK97976.1 - 0.089 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain Penicillinase_R PF03965.16 CDK97976.1 - 0.13 12.6 0.0 0.25 11.7 0.0 1.5 2 0 0 2 2 2 0 Penicillinase repressor HTH_AsnC-type PF13404.6 CDK97976.1 - 0.14 12.0 1.0 1.2 9.1 0.2 2.3 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain DUF1398 PF07166.11 CDK97977.1 - 5.8e-05 23.1 0.0 9.7e-05 22.4 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1398) Lysine_decarbox PF03641.14 CDK97978.1 - 3.5e-42 143.6 0.2 4.3e-42 143.3 0.2 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 CDK97978.1 - 3.5e-17 62.4 1.3 3.5e-17 62.4 1.3 1.4 2 0 0 2 2 2 1 SLOG cluster4 family TMP-TENI PF02581.17 CDK97979.1 - 5.9e-47 159.3 0.0 6.7e-47 159.2 0.0 1.0 1 0 0 1 1 1 1 Thiamine monophosphate synthase DRTGG PF07085.12 CDK97980.1 - 0.1 12.4 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 DRTGG domain DUF4164 PF13747.6 CDK97981.1 - 1.3e-06 28.6 4.1 0.001 19.3 1.0 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4164) OTCace_N PF02729.21 CDK97981.1 - 0.038 14.0 0.1 0.054 13.5 0.1 1.3 1 1 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain ZapA PF05164.13 CDK97982.1 - 3.1e-17 62.8 1.3 4.4e-17 62.3 1.3 1.2 1 0 0 1 1 1 1 Cell division protein ZapA XhlA PF10779.9 CDK97982.1 - 0.0012 19.0 1.4 0.0019 18.4 1.4 1.3 1 0 0 1 1 1 1 Haemolysin XhlA MscS_porin PF12795.7 CDK97982.1 - 0.0065 16.1 1.5 0.0084 15.7 1.5 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain Spc7 PF08317.11 CDK97982.1 - 0.015 14.2 0.2 0.016 14.1 0.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3422 PF11902.8 CDK97982.1 - 0.042 13.0 1.3 0.045 12.9 1.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3422) YjcZ PF13990.6 CDK97982.1 - 0.064 12.6 0.3 0.13 11.7 0.2 1.4 1 1 1 2 2 2 0 YjcZ-like protein Sec8_exocyst PF04048.14 CDK97982.1 - 0.08 12.8 0.2 0.13 12.1 0.2 1.3 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain DUF948 PF06103.11 CDK97982.1 - 0.1 12.9 0.2 0.39 11.0 0.1 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Prominin PF05478.11 CDK97982.1 - 0.13 10.2 0.3 0.15 10.0 0.3 1.0 1 0 0 1 1 1 0 Prominin 5-FTHF_cyc-lig PF01812.20 CDK97983.1 - 2.6e-28 99.1 0.0 3.1e-28 98.9 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family YmdB PF13277.6 CDK97984.1 - 1.5e-100 335.8 0.0 1.7e-100 335.6 0.0 1.0 1 0 0 1 1 1 1 YmdB-like protein PGA_cap PF09587.10 CDK97984.1 - 0.00032 20.2 0.2 0.079 12.4 0.0 2.2 2 0 0 2 2 2 2 Bacterial capsule synthesis protein PGA_cap Metallophos PF00149.28 CDK97984.1 - 0.044 14.3 0.3 0.17 12.3 0.3 1.8 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase NrsF PF06532.11 CDK97985.1 - 2.3e-32 112.4 30.1 2.6e-32 112.2 30.1 1.0 1 0 0 1 1 1 1 Negative regulator of sigma F EptA_B_N PF08019.12 CDK97985.1 - 0.13 12.2 0.1 0.13 12.2 0.1 2.2 2 1 0 2 2 2 0 Phosphoethanolamine transferase EptA/EptB Sigma70_r2 PF04542.14 CDK97986.1 - 2.2e-11 43.4 1.1 4.4e-11 42.4 1.1 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 CDK97986.1 - 5.3e-10 38.8 1.8 7.3e-10 38.4 0.4 2.0 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 CDK97986.1 - 2.3e-05 24.4 1.0 0.00012 22.0 1.0 1.8 1 1 0 1 1 1 1 ECF sigma factor Sigma70_r4 PF04545.16 CDK97986.1 - 0.00053 19.5 0.0 0.0012 18.3 0.0 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 PNPase PF03726.14 CDK97986.1 - 0.021 15.3 0.1 0.053 14.0 0.0 1.6 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Thioredoxin PF00085.20 CDK97987.1 - 2.8e-11 43.3 0.0 3.4e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 CDK97987.1 - 1.3e-05 25.2 0.1 2.5e-05 24.3 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 CDK97987.1 - 0.00039 20.8 0.1 0.0037 17.7 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.10 CDK97987.1 - 0.039 13.7 0.1 0.067 12.9 0.0 1.4 1 1 0 1 1 1 0 Redoxin Thioredoxin_8 PF13905.6 CDK97987.1 - 0.11 12.8 0.0 2.7 8.4 0.0 2.0 1 1 1 2 2 2 0 Thioredoxin-like DsbD PF02683.15 CDK97988.1 - 6e-18 65.5 25.1 4.4e-17 62.7 25.1 2.0 1 1 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DsbD_2 PF13386.6 CDK97988.1 - 2.1e-09 37.6 30.6 8.8e-09 35.6 30.5 1.8 1 1 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region Transcrip_reg PF01709.20 CDK97989.1 - 2.8e-92 308.5 0.0 3.2e-92 308.3 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator RuvC PF02075.17 CDK97990.1 - 3.5e-45 153.5 0.0 4e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 Crossover junction endodeoxyribonuclease RuvC RuvA_N PF01330.21 CDK97991.1 - 8e-20 70.7 0.1 3.9e-18 65.3 0.1 2.3 2 0 0 2 2 2 1 RuvA N terminal domain RuvA_C PF07499.13 CDK97991.1 - 1.4e-12 47.9 0.2 3.2e-12 46.7 0.2 1.7 1 0 0 1 1 1 1 RuvA, C-terminal domain HHH_5 PF14520.6 CDK97991.1 - 1.4e-12 48.0 1.4 2e-12 47.5 0.5 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH PF00633.23 CDK97991.1 - 0.00027 20.6 2.4 0.29 11.1 0.3 3.1 2 1 1 3 3 3 2 Helix-hairpin-helix motif Transposase_20 PF02371.16 CDK97991.1 - 0.087 13.2 1.4 4.3 7.7 0.2 2.3 2 0 0 2 2 2 0 Transposase IS116/IS110/IS902 family RuvB_N PF05496.12 CDK97992.1 - 6.7e-80 266.4 0.0 9.7e-80 265.9 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_4 PF17864.1 CDK97992.1 - 5e-30 103.1 0.6 9.6e-30 102.2 0.6 1.5 1 0 0 1 1 1 1 RuvB AAA lid domain RuvB_C PF05491.13 CDK97992.1 - 2.2e-28 97.9 0.0 3.7e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 RuvB C-terminal winged helix domain AAA PF00004.29 CDK97992.1 - 6.6e-17 62.2 0.0 1.1e-16 61.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDK97992.1 - 2e-06 27.9 0.1 0.029 14.4 0.0 2.4 1 1 1 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CDK97992.1 - 4.8e-05 22.7 0.2 0.00055 19.2 0.0 2.0 2 0 0 2 2 2 1 TIP49 P-loop domain Mg_chelatase PF01078.21 CDK97992.1 - 0.00012 21.5 0.1 0.022 14.1 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CDK97992.1 - 0.0004 20.7 0.3 0.14 12.4 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 CDK97992.1 - 0.0021 18.4 0.4 0.12 12.7 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_3 PF07726.11 CDK97992.1 - 0.0047 16.8 0.0 0.83 9.5 0.0 2.6 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CDK97992.1 - 0.0099 15.8 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain Sigma54_activat PF00158.26 CDK97992.1 - 0.01 15.6 0.0 1.6 8.4 0.0 2.2 1 1 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.6 CDK97992.1 - 0.013 16.1 0.0 0.035 14.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.6 CDK97992.1 - 0.015 15.4 0.0 0.042 14.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain PEPCK_ATP PF01293.20 CDK97992.1 - 0.069 11.8 0.0 0.098 11.3 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase NTPase_1 PF03266.15 CDK97992.1 - 0.076 12.9 0.2 0.76 9.7 0.0 2.1 1 1 0 2 2 2 0 NTPase TsaE PF02367.17 CDK97992.1 - 0.091 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 CDK97992.1 - 0.11 13.0 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CDK97992.1 - 0.16 12.0 0.0 0.47 10.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDK97992.1 - 0.2 12.1 0.0 0.3 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 CDK97992.1 - 0.23 10.6 0.0 1.1 8.4 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_24 PF13479.6 CDK97992.1 - 0.23 11.1 0.0 0.43 10.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Bac_DnaA PF00308.18 CDK97992.1 - 0.24 11.2 0.0 1.5 8.6 0.0 1.9 2 0 0 2 2 2 0 Bacterial dnaA protein 4HBT PF03061.22 CDK97993.1 - 1.4e-19 70.2 0.0 1.9e-19 69.8 0.0 1.1 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 CDK97993.1 - 5.7e-13 49.4 0.0 6.5e-13 49.2 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 CDK97993.1 - 0.0022 17.3 0.0 0.0026 17.1 0.0 1.1 1 0 0 1 1 1 1 Acyl-ACP thioesterase MotA_ExbB PF01618.16 CDK97994.1 - 7.1e-40 135.7 0.3 1.1e-39 135.1 0.3 1.3 1 0 0 1 1 1 1 MotA/TolQ/ExbB proton channel family DUF5305 PF17231.2 CDK97994.1 - 0.17 11.3 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) ExbD PF02472.16 CDK97995.1 - 9.7e-32 109.9 0.0 1.1e-31 109.7 0.0 1.0 1 0 0 1 1 1 1 Biopolymer transport protein ExbD/TolR TonB_2 PF13103.6 CDK97996.1 - 5.2e-05 23.4 0.2 5.2e-05 23.4 0.2 3.6 3 2 1 4 4 4 1 TonB C terminal TonB_C PF03544.14 CDK97996.1 - 0.062 13.7 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Gram-negative bacterial TonB protein C-terminal TolB_N PF04052.13 CDK97997.1 - 1.1e-34 118.7 0.0 1.8e-34 118.1 0.0 1.3 1 0 0 1 1 1 1 TolB amino-terminal domain PD40 PF07676.12 CDK97997.1 - 3.2e-22 77.9 15.8 8e-08 32.0 0.1 6.1 7 0 0 7 7 7 4 WD40-like Beta Propeller Repeat Pectate_lyase22 PF14583.6 CDK97997.1 - 6.3e-05 21.8 0.0 1.8 7.2 0.0 3.3 1 1 2 3 3 3 3 Oligogalacturonate lyase DPPIV_N PF00930.21 CDK97997.1 - 0.00031 19.6 0.0 0.14 10.9 0.0 3.6 2 1 2 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5050 PF16472.5 CDK97997.1 - 0.0038 16.5 0.0 0.12 11.5 0.0 2.4 1 1 2 3 3 3 2 Domain of unknown function (DUF5050) OmpA PF00691.20 CDK97998.1 - 3.8e-23 81.7 0.0 5.5e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 OmpA family Pilus_CpaD PF09476.10 CDK97998.1 - 0.026 14.3 0.2 0.055 13.2 0.2 1.5 1 1 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) TPR_16 PF13432.6 CDK97999.1 - 2.1e-09 37.8 0.1 9.9e-09 35.7 0.3 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat YfiO PF13525.6 CDK97999.1 - 3.5e-06 26.9 1.0 5.2e-06 26.3 1.0 1.3 1 0 0 1 1 1 1 Outer membrane lipoprotein TPR_6 PF13174.6 CDK97999.1 - 9.2e-05 22.8 0.7 1.1 10.1 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TolA_bind_tri PF16331.5 CDK97999.1 - 0.00018 21.5 10.0 0.0005 20.1 4.7 2.2 2 0 0 2 2 2 1 TolA binding protein trimerisation CLZ PF16526.5 CDK97999.1 - 0.00022 21.5 4.7 0.26 11.7 2.9 2.4 2 0 0 2 2 2 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TPR_2 PF07719.17 CDK97999.1 - 0.0023 17.9 3.0 3.9 7.8 0.5 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat Aida_N PF08910.10 CDK97999.1 - 0.0053 17.1 1.2 0.013 15.9 0.7 1.8 2 0 0 2 2 2 1 Aida N-terminus KLRAQ PF10205.9 CDK97999.1 - 0.018 15.3 0.5 0.018 15.3 0.5 2.0 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein SlyX PF04102.12 CDK97999.1 - 0.02 15.5 8.8 0.17 12.5 5.7 2.4 2 0 0 2 2 2 0 SlyX Apolipoprotein PF01442.18 CDK97999.1 - 0.044 13.6 5.0 0.071 13.0 5.0 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Sugarporin_N PF11471.8 CDK97999.1 - 0.061 13.3 0.1 0.061 13.3 0.1 1.9 2 0 0 2 2 1 0 Maltoporin periplasmic N-terminal extension COG6 PF06419.11 CDK97999.1 - 0.1 10.8 0.4 0.18 10.0 0.4 1.3 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 HSBP1 PF06825.12 CDK97999.1 - 0.13 12.2 2.0 2.8 7.8 1.1 2.5 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Cep57_MT_bd PF06657.13 CDK97999.1 - 0.69 10.4 4.0 2.3 8.7 1.6 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 ATP_bind_3 PF01171.20 CDK98000.1 - 3.7e-47 160.4 0.0 5.1e-47 160.0 0.0 1.1 1 0 0 1 1 1 1 PP-loop family TilS_C PF11734.8 CDK98000.1 - 0.037 13.5 0.2 0.088 12.2 0.2 1.6 1 0 0 1 1 1 0 TilS substrate C-terminal domain Phage_int_SAM_3 PF14659.6 CDK98000.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Tail_spike_N PF18668.1 CDK98000.1 - 0.14 12.1 0.5 0.26 11.2 0.5 1.4 1 0 0 1 1 1 0 Tail spike TSP1/Gp66 receptor binding N-terminal domain Peptidase_M41 PF01434.18 CDK98001.1 - 1.3e-71 240.4 1.0 3.5e-71 239.0 0.3 1.9 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 CDK98001.1 - 2e-46 157.7 0.0 1.2e-45 155.2 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDK98001.1 - 9.3e-11 41.4 0.0 1.8e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 CDK98001.1 - 1.8e-08 34.7 0.1 5.5e-08 33.1 0.0 1.8 2 0 0 2 2 2 1 FtsH Extracellular AAA_5 PF07728.14 CDK98001.1 - 1.2e-06 28.5 0.0 7.8e-06 25.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CDK98001.1 - 6.4e-05 22.3 0.0 0.00015 21.1 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 CDK98001.1 - 0.00021 21.7 0.1 0.0011 19.4 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CDK98001.1 - 0.00049 19.9 0.0 0.0022 17.8 0.0 2.2 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDK98001.1 - 0.0022 18.3 0.2 0.035 14.4 0.0 2.6 2 1 1 3 3 2 1 AAA domain IstB_IS21 PF01695.17 CDK98001.1 - 0.005 16.6 0.0 0.0088 15.8 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 CDK98001.1 - 0.0051 16.9 0.1 0.019 15.1 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CDK98001.1 - 0.022 14.9 0.0 0.044 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CDK98001.1 - 0.026 13.9 0.1 0.06 12.7 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CDK98001.1 - 0.034 14.4 0.1 0.31 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CDK98001.1 - 0.1 13.0 0.0 0.29 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CDK98001.1 - 0.14 12.3 0.1 13 5.9 0.0 3.2 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_7 PF12775.7 CDK98001.1 - 0.17 11.4 0.1 0.54 9.7 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 CDK98001.1 - 0.18 11.1 0.2 0.65 9.2 0.1 1.9 1 1 1 2 2 2 0 Zeta toxin ABC_tran PF00005.27 CDK98001.1 - 0.19 12.3 0.3 0.52 10.8 0.1 1.8 2 0 0 2 2 1 0 ABC transporter Pterin_bind PF00809.22 CDK98002.1 - 4.5e-78 262.3 0.0 5.6e-78 262.0 0.0 1.1 1 0 0 1 1 1 1 Pterin binding enzyme DUF4239 PF14023.6 CDK98003.1 - 5.5e-13 49.1 0.4 7.2e-13 48.8 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4239) Glucos_trans_II PF14264.6 CDK98003.1 - 0.0082 15.5 0.7 0.019 14.3 0.0 1.8 2 0 0 2 2 2 1 Glucosyl transferase GtrII DUF1428 PF07237.11 CDK98003.1 - 0.039 14.2 0.0 0.068 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1428) AraC_N PF06719.13 CDK98003.1 - 0.052 13.2 0.0 0.094 12.4 0.0 1.4 1 0 0 1 1 1 0 AraC-type transcriptional regulator N-terminus DUF2269 PF10027.9 CDK98003.1 - 1.8 8.6 9.1 0.3 11.1 1.0 2.9 4 1 0 4 4 4 0 Predicted integral membrane protein (DUF2269) LysE PF01810.18 CDK98004.1 - 1.9e-21 76.4 17.9 2.2e-21 76.2 17.9 1.0 1 0 0 1 1 1 1 LysE type translocator PGM_PMM_I PF02878.16 CDK98005.1 - 1.1e-41 141.7 0.0 2.3e-41 140.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CDK98005.1 - 4.4e-33 113.9 0.1 8.2e-33 113.0 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CDK98005.1 - 1.3e-17 64.3 0.0 4.5e-17 62.6 0.0 2.0 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CDK98005.1 - 2.9e-16 59.4 0.5 6.6e-16 58.2 0.5 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RNase_T PF00929.24 CDK98006.1 - 4.2e-37 128.2 0.0 8.4e-37 127.3 0.0 1.5 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 CDK98006.1 - 3.2e-06 27.0 0.0 0.00011 22.0 0.0 2.3 2 0 0 2 2 2 1 3'-5' exonuclease PAS PF00989.25 CDK98006.1 - 0.00054 19.9 0.0 0.00099 19.1 0.0 1.5 1 0 0 1 1 1 1 PAS fold DUF2384 PF09722.10 CDK98006.1 - 0.0037 17.3 0.6 0.024 14.7 0.0 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2384) PAS_10 PF13596.6 CDK98006.1 - 0.01 16.4 0.0 0.022 15.3 0.0 1.6 1 0 0 1 1 1 0 PAS domain PAS_8 PF13188.7 CDK98006.1 - 0.026 14.6 0.0 0.088 12.9 0.0 2.0 1 0 0 1 1 1 0 PAS domain PAS_9 PF13426.7 CDK98006.1 - 0.034 14.4 0.0 0.079 13.2 0.0 1.7 1 0 0 1 1 1 0 PAS domain H-kinase_dim PF02895.14 CDK98006.1 - 0.14 12.6 0.1 0.53 10.7 0.1 2.0 1 0 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain BLOC1_2 PF10046.9 CDK98006.1 - 0.14 12.4 0.3 1.5 9.1 0.1 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2148 PF09918.9 CDK98007.1 - 0.15 12.1 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a ferredoxin domain (DUF2148) SBP_bac_3 PF00497.20 CDK98008.1 - 6e-12 45.5 0.0 7.9e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Phosphonate-bd PF12974.7 CDK98008.1 - 9.1e-06 25.4 0.0 3.5e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein MCPsignal PF00015.21 CDK98009.1 - 2.2e-31 109.0 19.2 2.2e-31 109.0 19.2 4.4 3 1 2 5 5 5 1 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK98009.1 - 1.3e-09 38.3 0.1 1.3e-09 38.3 0.1 4.6 5 1 0 5 5 5 1 HAMP domain BLOC1_2 PF10046.9 CDK98009.1 - 0.0021 18.3 9.6 1.7 9.0 0.2 5.2 4 2 1 5 5 5 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_13 PF13166.6 CDK98009.1 - 0.003 16.3 6.5 0.003 16.3 6.5 1.9 2 0 0 2 2 2 1 AAA domain DUF1664 PF07889.12 CDK98009.1 - 0.0037 17.3 12.8 0.79 9.8 2.8 4.8 4 1 1 5 5 5 3 Protein of unknown function (DUF1664) DUF3450 PF11932.8 CDK98009.1 - 0.019 14.3 0.6 0.019 14.3 0.6 4.2 4 1 1 5 5 5 0 Protein of unknown function (DUF3450) DUF812 PF05667.11 CDK98009.1 - 0.032 13.1 10.6 0.03 13.2 5.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF3130 PF11328.8 CDK98009.1 - 0.066 13.5 2.1 1.4 9.2 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3130 Flagellar_rod PF05149.12 CDK98009.1 - 2.3 7.6 11.0 0.52 9.7 1.0 3.4 3 1 0 3 3 3 0 Paraflagellar rod protein DUF948 PF06103.11 CDK98009.1 - 9.8 6.5 28.6 1.2 9.5 1.7 6.3 5 1 1 6 6 6 0 Bacterial protein of unknown function (DUF948) MFS_1 PF07690.16 CDK98010.1 - 3.1e-38 131.6 81.5 3.2e-31 108.6 44.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDK98010.1 - 3.3e-08 32.8 6.5 3.3e-08 32.8 6.5 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter PTR2 PF00854.21 CDK98010.1 - 0.00011 21.1 0.8 0.00018 20.5 0.1 1.7 2 0 0 2 2 2 1 POT family MobB PF03205.14 CDK98011.1 - 1.8e-31 108.8 0.0 2.4e-31 108.4 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.6 CDK98011.1 - 0.0018 18.0 0.5 0.0032 17.2 0.5 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 CDK98011.1 - 0.0022 17.7 0.3 0.019 14.7 0.3 2.0 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 CDK98011.1 - 0.0026 17.5 0.1 0.0039 16.9 0.1 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family ABC_tran PF00005.27 CDK98011.1 - 0.0068 16.9 0.0 0.0068 16.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter cobW PF02492.19 CDK98011.1 - 0.009 15.6 0.2 0.019 14.5 0.2 1.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CDK98011.1 - 0.012 14.6 0.1 0.02 13.9 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 CDK98011.1 - 0.016 15.7 0.2 0.021 15.3 0.2 1.1 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDK98011.1 - 0.019 15.3 0.1 0.026 14.9 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain CbiA PF01656.23 CDK98011.1 - 0.02 14.9 0.3 0.03 14.4 0.3 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 CDK98011.1 - 0.054 13.3 0.1 0.078 12.7 0.1 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 CDK98011.1 - 0.062 13.2 0.3 0.19 11.6 0.1 1.8 2 0 0 2 2 2 0 NTPase RsgA_GTPase PF03193.16 CDK98011.1 - 0.076 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_33 PF13671.6 CDK98011.1 - 0.1 12.8 0.1 0.3 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF463 PF04317.12 CDK98011.1 - 0.11 11.4 0.2 0.15 11.0 0.2 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 T2SSE PF00437.20 CDK98011.1 - 0.16 11.0 0.3 0.27 10.2 0.3 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 CDK98011.1 - 0.22 11.1 2.2 1.5 8.4 0.2 2.5 2 1 0 3 3 3 0 AAA domain Response_reg PF00072.24 CDK98013.1 - 9.8e-22 77.2 0.0 1.5e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 CDK98013.1 - 6.5e-20 70.4 0.3 1.1e-19 69.7 0.3 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDK98013.1 - 1e-07 31.5 0.1 1.7e-07 30.8 0.1 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 CDK98013.1 - 0.00045 19.7 0.1 0.00097 18.6 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 CENP-B_N PF04218.13 CDK98013.1 - 0.00082 19.0 0.2 0.0026 17.4 0.1 1.8 1 1 1 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_40 PF14493.6 CDK98013.1 - 0.0014 19.0 0.0 0.0052 17.2 0.1 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDK98013.1 - 0.0021 17.8 0.1 0.0099 15.7 0.0 2.1 1 1 1 2 2 2 1 Homeodomain-like domain Glyco_hydro_3_C PF01915.22 CDK98013.1 - 0.022 14.7 0.1 0.048 13.6 0.0 1.5 1 1 1 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain HTH_38 PF13936.6 CDK98013.1 - 0.025 14.3 0.0 0.071 12.9 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_20 PF12840.7 CDK98013.1 - 0.025 14.6 0.4 0.072 13.2 0.3 1.9 1 1 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.7 CDK98013.1 - 0.031 14.2 1.0 0.14 12.1 0.0 2.6 3 1 0 3 3 3 0 MarR family HTH_7 PF02796.15 CDK98013.1 - 0.076 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase EcoEI_R_C PF08463.10 CDK98013.1 - 0.092 12.9 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 EcoEI R protein C-terminal DUF2089 PF09862.9 CDK98013.1 - 0.099 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) HTH_24 PF13412.6 CDK98013.1 - 0.11 12.0 0.7 0.52 9.9 0.1 2.1 1 1 1 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 CDK98013.1 - 0.12 12.5 0.1 1.7 8.8 0.0 2.8 2 1 1 3 3 3 0 Helix-turn-helix domain LexA_DNA_bind PF01726.16 CDK98013.1 - 0.14 12.0 0.3 1 9.2 0.3 2.3 1 1 0 1 1 1 0 LexA DNA binding domain DUF3071 PF11268.8 CDK98013.1 - 0.14 12.2 0.1 0.16 12.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) LPAM_1 PF08139.12 CDK98014.1 - 8.5e-05 22.8 0.4 0.00015 22.1 0.4 1.4 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site DUF3515 PF12028.8 CDK98014.1 - 0.097 12.4 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3515) RNase_E_G PF10150.9 CDK98015.1 - 1.6e-94 316.3 0.2 2.5e-94 315.7 0.2 1.3 1 0 0 1 1 1 1 Ribonuclease E/G family S1 PF00575.23 CDK98015.1 - 7.9e-06 26.1 0.3 0.00039 20.7 0.0 2.9 2 0 0 2 2 2 1 S1 RNA binding domain Amidase_3 PF01520.18 CDK98016.1 - 2.4e-48 164.5 0.0 3.8e-48 163.9 0.0 1.3 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase AMIN PF11741.8 CDK98016.1 - 1.6e-06 28.1 0.0 0.0011 19.0 0.0 3.5 2 1 1 3 3 3 2 AMIN domain Transgly PF00912.22 CDK98017.1 - 9.8e-58 194.5 0.0 1.4e-57 194.0 0.0 1.2 1 0 0 1 1 1 1 Transglycosylase Transpeptidase PF00905.22 CDK98017.1 - 1.1e-36 126.6 0.0 3.8e-36 124.8 0.0 1.9 1 1 0 1 1 1 1 Penicillin binding protein transpeptidase domain PCB_OB PF17092.5 CDK98017.1 - 1.4e-26 93.4 0.4 2.6e-26 92.6 0.4 1.4 1 0 0 1 1 1 1 Penicillin-binding protein OB-like domain PCRF PF03462.18 CDK98018.1 - 3.9e-59 199.8 1.2 5.3e-59 199.3 0.1 1.7 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 CDK98018.1 - 3.4e-42 143.0 1.4 6.8e-42 142.1 0.2 2.0 2 1 1 3 3 3 1 RF-1 domain ABC_tran_CTD PF16326.5 CDK98018.1 - 0.37 11.1 0.0 0.37 11.1 0.0 3.7 5 0 0 5 5 5 0 ABC transporter C-terminal domain Tim44 PF04280.15 CDK98019.1 - 1.6e-18 67.2 0.3 2.1e-18 66.9 0.3 1.1 1 0 0 1 1 1 1 Tim44-like domain TraT PF05818.12 CDK98020.1 - 3.3e-09 36.8 0.1 4.6e-09 36.3 0.1 1.3 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein Gly-zipper_YMGG PF13441.6 CDK98020.1 - 0.022 14.5 24.6 0.022 14.5 24.6 1.7 2 0 0 2 2 2 0 YMGG-like Gly-zipper Trypsin_2 PF13365.6 CDK98021.1 - 1.2e-24 88.0 0.1 4e-24 86.2 0.0 1.9 2 0 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDK98021.1 - 3e-14 53.4 0.0 8.8e-14 51.8 0.0 1.7 1 1 0 1 1 1 1 Trypsin Chlorosome_CsmC PF11098.8 CDK98022.1 - 0.043 13.8 3.7 0.14 12.1 3.7 1.8 1 1 0 1 1 1 0 Chlorosome envelope protein C Moricin PF06451.11 CDK98022.1 - 0.11 12.3 8.8 1.5 8.7 0.4 3.8 1 1 3 4 4 4 0 Moricin HTH_Tnp_1 PF01527.20 CDK98024.1 - 3e-16 59.5 0.3 4.5e-16 58.9 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDK98024.1 - 3.9e-06 26.5 0.0 6.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 CDK98024.1 - 0.0076 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 CDK98024.1 - 0.02 15.0 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 CDK98024.1 - 0.045 13.4 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.6 CDK98024.1 - 0.076 13.0 0.2 0.68 10.0 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn helix HTH_35 PF13693.6 CDK98024.1 - 0.13 12.3 0.0 1 9.4 0.0 2.0 1 1 1 2 2 2 0 Winged helix-turn-helix DNA-binding TnpB_IS66 PF05717.13 CDK98025.1 - 9.3e-38 128.2 0.0 1e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein DDE_Tnp_IS66 PF03050.14 CDK98026.1 - 2.9e-89 299.3 0.4 4.9e-89 298.6 0.0 1.6 2 0 0 2 2 2 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK98026.1 - 2.9e-18 65.8 0.0 1e-17 64.0 0.0 2.0 1 0 0 1 1 1 1 IS66 C-terminal element LZ_Tnp_IS66 PF13007.7 CDK98026.1 - 3e-16 59.9 4.3 3e-16 59.9 4.3 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDK98026.1 - 1.5e-15 57.3 4.6 2.9e-15 56.4 4.6 1.5 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDK98026.1 - 0.18 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.12 CDK98026.1 - 1.1 10.0 3.9 11 6.8 2.2 2.9 2 1 1 3 3 3 0 SlyX PsbQ PF05757.11 CDK98027.1 - 0.022 14.5 0.5 0.025 14.3 0.5 1.0 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) FAD-SLDH PF12318.8 CDK98027.1 - 0.15 12.1 0.2 0.19 11.8 0.2 1.1 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase Cupin_4 PF08007.12 CDK98028.1 - 8e-42 143.8 0.0 9.8e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 CDK98028.1 - 4.7e-06 26.5 0.0 0.0042 16.8 0.0 2.2 2 0 0 2 2 2 2 Cupin-like domain Cupin_2 PF07883.11 CDK98028.1 - 0.0014 18.3 0.0 0.05 13.3 0.0 2.4 2 0 0 2 2 2 1 Cupin domain AraC_binding PF02311.19 CDK98028.1 - 0.012 15.5 0.1 0.031 14.2 0.1 1.8 1 1 0 1 1 1 0 AraC-like ligand binding domain Cupin_1 PF00190.22 CDK98028.1 - 0.15 11.7 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 Cupin PRK PF00485.18 CDK98029.1 - 1.7e-75 253.1 0.0 2e-75 252.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family APS_kinase PF01583.20 CDK98029.1 - 0.003 17.5 0.0 0.0045 16.9 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase MeaB PF03308.16 CDK98029.1 - 0.0053 15.8 0.0 0.0088 15.1 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 CDK98029.1 - 0.17 11.2 0.1 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin RuBisCO_large PF00016.20 CDK98030.1 - 3.1e-117 391.1 0.1 1.1e-116 389.2 0.2 1.7 2 0 0 2 2 2 1 Ribulose bisphosphate carboxylase large chain, catalytic domain RuBisCO_large_N PF02788.16 CDK98030.1 - 3.3e-40 137.0 0.0 5.4e-40 136.3 0.0 1.3 1 0 0 1 1 1 1 Ribulose bisphosphate carboxylase large chain, N-terminal domain Radical_SAM PF04055.21 CDK98031.1 - 5e-20 72.5 0.0 8.9e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily HemN_C PF06969.16 CDK98031.1 - 1.2e-11 44.5 0.1 3.1e-11 43.2 0.1 1.8 1 0 0 1 1 1 1 HemN C-terminal domain RcnB PF11776.8 CDK98032.1 - 0.0051 16.8 0.0 0.031 14.3 0.0 2.1 2 0 0 2 2 2 1 Nickel/cobalt transporter regulator HATPase_c PF02518.26 CDK98033.1 - 3.1e-25 88.8 0.1 5.5e-25 88.0 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 CDK98033.1 - 1.5e-24 86.2 0.0 1.8e-21 76.4 0.0 3.2 2 1 0 2 2 2 1 PAS domain NIT PF08376.10 CDK98033.1 - 3.4e-24 86.6 13.1 3.4e-24 86.6 13.1 2.3 3 0 0 3 3 3 1 Nitrate and nitrite sensing PAS_4 PF08448.10 CDK98033.1 - 5.3e-20 71.7 0.0 1.1e-10 41.7 0.0 3.5 2 1 0 2 2 2 2 PAS fold PAS PF00989.25 CDK98033.1 - 1.2e-18 67.1 0.0 2e-15 56.7 0.0 3.3 3 0 0 3 3 3 2 PAS fold HisKA PF00512.25 CDK98033.1 - 1.6e-18 66.5 1.1 7.4e-18 64.4 0.1 2.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 CDK98033.1 - 6.2e-14 52.1 0.0 1.2e-12 47.9 0.0 3.0 3 0 0 3 3 3 1 PAS fold PAS_8 PF13188.7 CDK98033.1 - 5.3e-12 45.5 0.0 6.5e-06 26.1 0.0 3.0 2 0 0 2 2 2 2 PAS domain HATPase_c_2 PF13581.6 CDK98033.1 - 0.0016 18.4 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 CDK98033.1 - 0.0023 17.8 0.0 0.005 16.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Phasin_2 PF09361.10 CDK98033.1 - 0.02 15.1 2.2 0.053 13.8 0.5 2.6 2 0 0 2 2 2 0 Phasin protein HATPase_c PF02518.26 CDK98034.1 - 7.9e-28 97.2 0.0 1.7e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98034.1 - 6e-13 48.6 10.4 2.6e-12 46.6 0.2 4.4 4 1 0 4 4 4 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDK98034.1 - 0.00091 19.6 0.8 0.00091 19.6 0.8 3.8 4 0 0 4 4 4 1 HAMP domain DnaG_DnaB_bind PF08278.11 CDK98034.1 - 0.0065 17.1 3.4 0.0065 17.1 3.4 3.1 3 1 0 3 3 3 1 DNA primase DnaG DnaB-binding Synaptobrevin PF00957.21 CDK98034.1 - 0.019 14.8 1.3 0.67 9.8 0.1 2.8 2 0 0 2 2 2 0 Synaptobrevin COG4 PF08318.12 CDK98034.1 - 0.056 12.5 0.1 0.093 11.8 0.1 1.3 1 0 0 1 1 1 0 COG4 transport protein Med30 PF11315.8 CDK98034.1 - 0.066 13.4 3.1 0.28 11.4 0.0 2.7 2 1 0 2 2 2 0 Mediator complex subunit 30 TipAS PF07739.13 CDK98034.1 - 0.18 12.4 0.2 0.18 12.4 0.2 3.8 2 2 2 4 4 4 0 TipAS antibiotic-recognition domain 4HB_MCP_1 PF12729.7 CDK98034.1 - 0.19 11.3 2.0 0.27 10.7 0.1 2.3 2 1 0 2 2 2 0 Four helix bundle sensory module for signal transduction Rrf2 PF02082.20 CDK98035.1 - 1.5e-21 76.5 0.1 2.4e-21 75.9 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator HTH_20 PF12840.7 CDK98035.1 - 8.6e-06 25.7 0.1 2.9e-05 24.0 0.1 1.9 1 1 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 CDK98035.1 - 1e-05 25.4 0.0 2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 CDK98035.1 - 0.0023 17.8 0.0 0.0037 17.1 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 CDK98035.1 - 0.0023 17.9 0.1 0.0062 16.5 0.1 1.7 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain Rio2_N PF09202.11 CDK98035.1 - 0.0065 16.7 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 Rio2, N-terminal HTH_6 PF01418.17 CDK98035.1 - 0.011 15.7 0.0 0.1 12.6 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family MarR PF01047.22 CDK98035.1 - 0.021 14.8 0.0 0.053 13.5 0.0 1.7 2 0 0 2 2 2 0 MarR family HTH_27 PF13463.6 CDK98035.1 - 0.04 14.4 0.0 0.065 13.7 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain DUF1323 PF07037.11 CDK98035.1 - 0.1 13.0 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) HTH_IclR PF09339.10 CDK98035.1 - 0.11 12.3 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain Hpt PF01627.23 CDK98036.1 - 0.00027 21.1 0.2 0.00053 20.2 0.2 1.6 1 0 0 1 1 1 1 Hpt domain Response_reg PF00072.24 CDK98036.1 - 0.00065 19.8 0.0 0.0025 18.0 0.0 1.9 2 1 0 2 2 2 1 Response regulator receiver domain EspB_PE PF18625.1 CDK98036.1 - 0.1 13.1 0.5 0.27 11.7 0.2 1.9 2 0 0 2 2 2 0 ESX-1 secreted protein B PE domain HicB_lk_antitox PF15919.5 CDK98036.1 - 0.13 12.3 0.0 0.74 9.9 0.0 2.0 2 0 0 2 2 2 0 HicB_like antitoxin of bacterial toxin-antitoxin system PCDO_beta_N PF12391.8 CDK98036.1 - 0.16 11.6 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 Protocatechuate 3,4-dioxygenase beta subunit N terminal HlyD_3 PF13437.6 CDK98037.1 - 1.3e-17 64.4 1.6 2.1e-15 57.3 0.1 3.1 2 1 1 3 3 3 1 HlyD family secretion protein HlyD_D23 PF16576.5 CDK98037.1 - 9e-13 47.9 12.5 5.4e-10 38.8 0.9 2.9 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK98037.1 - 1.5e-05 24.7 5.0 0.00047 19.9 0.2 4.3 4 1 0 4 4 4 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK98037.1 - 2.8e-05 23.9 0.7 0.042 13.7 0.1 2.9 2 1 0 2 2 2 2 Biotin-requiring enzyme HlyD PF00529.20 CDK98037.1 - 9.7e-05 22.2 8.5 0.00027 20.8 8.5 2.0 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS PTS_EIIA_1 PF00358.20 CDK98037.1 - 0.024 14.4 0.0 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Presenilin PF01080.17 CDK98037.1 - 0.046 12.5 0.8 0.064 12.0 0.8 1.2 1 0 0 1 1 1 0 Presenilin putAbiC PF16872.5 CDK98037.1 - 0.17 12.6 0.4 0.32 11.7 0.4 1.4 1 0 0 1 1 1 0 Putative phage abortive infection protein TFIIA PF03153.13 CDK98037.1 - 2 8.3 11.8 2.8 7.8 11.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CEP19 PF14933.6 CDK98037.1 - 6.7 7.0 6.6 12 6.2 6.6 1.4 1 0 0 1 1 1 0 CEP19-like protein ABC_tran PF00005.27 CDK98038.1 - 4.4e-33 114.7 0.0 1e-32 113.5 0.0 1.6 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 CDK98038.1 - 3.5e-29 102.3 2.6 4.6e-29 101.9 2.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.6 CDK98038.1 - 7.9e-11 42.3 0.3 0.00026 20.9 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDK98038.1 - 5.9e-05 23.7 0.1 9.6e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDK98038.1 - 9.7e-05 21.9 0.1 0.12 11.8 0.1 2.5 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDK98038.1 - 0.00011 21.8 0.2 0.00031 20.4 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CDK98038.1 - 0.00035 20.4 0.0 0.024 14.4 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain DUF3584 PF12128.8 CDK98038.1 - 0.0038 14.8 0.0 0.0055 14.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_16 PF13191.6 CDK98038.1 - 0.0079 16.6 0.7 0.031 14.7 0.4 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDK98038.1 - 0.043 14.1 0.1 0.19 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CDK98038.1 - 0.087 12.7 0.7 0.22 11.4 0.7 1.6 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 CDK98038.1 - 0.095 12.4 1.9 0.31 10.7 0.0 2.4 3 0 0 3 3 3 0 AAA domain CbiA PF01656.23 CDK98038.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 CDK98038.1 - 0.2 11.8 0.7 0.87 9.7 0.7 2.1 1 1 0 1 1 1 0 AAA domain OEP PF02321.18 CDK98039.1 - 1.5e-47 161.8 18.4 6.5e-26 91.3 11.2 2.0 2 0 0 2 2 2 2 Outer membrane efflux protein GntR PF00392.21 CDK98040.1 - 2.3e-11 43.2 1.2 3.7e-11 42.5 1.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family FCD PF07729.12 CDK98040.1 - 0.012 16.0 1.4 0.71 10.3 0.6 2.3 2 0 0 2 2 2 0 FCD domain TrmB PF01978.19 CDK98040.1 - 0.035 14.0 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 CDK98040.1 - 0.088 12.8 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain TerC PF03741.16 CDK98041.1 - 3.7e-42 144.1 18.8 4.7e-42 143.7 18.8 1.1 1 0 0 1 1 1 1 Integral membrane protein TerC family DUF3318 PF11780.8 CDK98041.1 - 0.0093 15.9 2.5 0.0093 15.9 2.5 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF3318) UPF0542 PF15086.6 CDK98041.1 - 0.037 14.0 0.8 0.35 10.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 TMEM100 PF16311.5 CDK98041.1 - 0.15 11.7 9.2 0.087 12.4 2.3 2.4 1 1 1 2 2 2 0 Transmembrane protein 100 ENOD93 PF03386.14 CDK98041.1 - 0.84 9.6 13.2 1.7 8.6 4.0 2.9 2 2 0 2 2 2 0 Early nodulin 93 ENOD93 protein DUF2085 PF09858.9 CDK98041.1 - 4.2 7.9 11.7 5.1 7.6 2.0 2.6 1 1 0 2 2 2 0 Predicted membrane protein (DUF2085) Gate PF07670.14 CDK98042.1 - 1.3e-10 41.6 16.5 2.8e-08 34.0 0.8 3.4 3 2 0 3 3 3 2 Nucleoside recognition Ribosomal_L11_N PF03946.14 CDK98042.1 - 0.032 14.1 0.5 0.16 11.8 0.5 2.2 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain Atg14 PF10186.9 CDK98042.1 - 0.19 10.8 0.7 0.26 10.4 0.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_9 PF13371.6 CDK98043.1 - 0.024 14.8 1.6 0.054 13.6 1.6 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2155 PF09923.9 CDK98044.1 - 3.1e-35 120.3 0.0 3.7e-35 120.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2155) MlaD PF02470.20 CDK98045.1 - 1.8e-20 73.0 0.2 2.4e-20 72.6 0.2 1.1 1 0 0 1 1 1 1 MlaD protein MlaD PF02470.20 CDK98046.1 - 3e-18 65.9 0.1 4.1e-18 65.5 0.1 1.2 1 0 0 1 1 1 1 MlaD protein PsbX PF06596.11 CDK98046.1 - 0.29 11.2 2.5 0.46 10.5 2.5 1.3 1 0 0 1 1 1 0 Photosystem II reaction centre X protein (PsbX) NDUFA12 PF05071.16 CDK98047.1 - 3.4e-25 88.7 0.9 4e-25 88.5 0.9 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Ribonuc_red_lgC PF02867.15 CDK98048.1 - 1.3e-123 413.3 0.0 5.4e-105 351.9 0.0 2.3 2 0 0 2 2 2 2 Ribonucleotide reductase, barrel domain Ribonuc_red_2_N PF08471.10 CDK98048.1 - 1.8e-40 137.1 0.0 6.2e-40 135.4 0.0 2.0 1 0 0 1 1 1 1 Class II vitamin B12-dependent ribonucleotide reductase Transcrip_reg PF01709.20 CDK98048.1 - 0.02 14.3 0.2 0.039 13.4 0.2 1.4 1 0 0 1 1 1 0 Transcriptional regulator RNA_POL_M_15KD PF02150.16 CDK98048.1 - 2.7 7.9 5.0 6.6 6.7 5.0 1.6 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit UvrA_inter PF17760.1 CDK98049.1 - 0.012 15.7 1.3 0.02 15.0 1.3 1.3 1 0 0 1 1 1 0 UvrA interaction domain LCIB_C_CA PF18599.1 CDK98049.1 - 0.07 12.4 1.9 0.1 11.9 1.9 1.3 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases SAC3 PF12209.8 CDK98049.1 - 0.099 12.8 3.2 1.2 9.3 0.2 2.6 2 1 1 3 3 3 0 Leucine permease transcriptional regulator helical domain DUF2780 PF11075.8 CDK98049.1 - 0.25 11.5 0.4 0.25 11.5 0.4 2.3 2 1 1 3 3 3 0 Protein of unknown function VcgC/VcgE (DUF2780) YpjP PF14005.6 CDK98049.1 - 0.48 10.5 3.9 0.69 9.9 3.6 1.4 1 1 0 1 1 1 0 YpjP-like protein DUF4333 PF14230.6 CDK98049.1 - 0.58 10.4 2.8 13 6.1 0.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4333) ORF6C PF10552.9 CDK98049.1 - 0.59 10.2 7.6 0.2 11.7 1.6 2.0 1 1 1 2 2 2 0 ORF6C domain DUF445 PF04286.12 CDK98049.1 - 1.1 9.0 8.0 1.7 8.4 8.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF445) AvrM-A PF18241.1 CDK98049.1 - 1.2 9.6 8.6 1.6 9.2 8.6 1.2 1 0 0 1 1 1 0 Flax-rust effector AvrM-A PNPase PF03726.14 CDK98049.1 - 5.5 7.6 9.2 3.7 8.1 1.5 2.7 1 1 2 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Leu_Phe_trans PF03588.14 CDK98050.1 - 2.8e-66 222.2 0.0 3.2e-66 222.0 0.0 1.0 1 0 0 1 1 1 1 Leucyl/phenylalanyl-tRNA protein transferase Acetyltransf_6 PF13480.7 CDK98050.1 - 0.029 14.5 0.2 0.05 13.8 0.2 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF1476 PF07345.11 CDK98051.1 - 8.4e-10 38.9 0.3 9.8e-10 38.7 0.3 1.1 1 0 0 1 1 1 1 ATPase inhibitor subunit zeta LprI PF07007.12 CDK98052.1 - 1.2e-07 32.3 0.5 7.9e-07 29.7 0.0 2.5 2 0 0 2 2 2 1 Lysozyme inhibitor LprI Nitro_FeMo-Co PF02579.17 CDK98053.1 - 0.00024 21.4 0.1 0.00067 19.9 0.1 1.6 1 1 0 1 1 1 1 Dinitrogenase iron-molybdenum cofactor Response_reg PF00072.24 CDK98054.1 - 1.3e-27 96.2 0.5 2.2e-27 95.4 0.1 1.6 2 0 0 2 2 2 1 Response regulator receiver domain GerE PF00196.19 CDK98054.1 - 1.3e-22 79.1 0.9 2.2e-22 78.4 0.4 1.6 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDK98054.1 - 3.2e-06 26.7 0.2 7.7e-06 25.5 0.2 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 CDK98054.1 - 0.0081 15.9 0.2 0.024 14.4 0.2 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_40 PF14493.6 CDK98054.1 - 0.042 14.3 0.3 0.11 12.9 0.4 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4 PF04545.16 CDK98054.1 - 0.074 12.6 0.2 0.21 11.1 0.2 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 HisKA_2 PF07568.12 CDK98055.1 - 3.8e-09 36.5 0.0 9e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase HWE_HK PF07536.14 CDK98055.1 - 3e-08 34.2 0.5 1.9e-07 31.7 0.2 2.5 2 0 0 2 2 2 1 HWE histidine kinase DciA PF05258.12 CDK98055.1 - 0.023 15.1 0.2 0.13 12.6 0.1 2.3 2 0 0 2 2 2 0 Dna[CI] antecedent, DciA CBP PF12192.8 CDK98055.1 - 0.15 12.3 3.0 0.28 11.4 3.0 1.5 1 0 0 1 1 1 0 Fungal calcium binding protein Response_reg PF00072.24 CDK98056.1 - 8.1e-21 74.3 0.0 1.3e-20 73.7 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 CDK98056.1 - 5.9e-18 64.2 0.6 8.3e-18 63.7 0.1 1.5 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDK98056.1 - 0.0011 18.5 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 Response_reg PF00072.24 CDK98057.1 - 4.6e-23 81.5 0.0 6.9e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CDK98057.1 - 0.0049 16.9 0.2 0.013 15.5 0.1 1.7 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain IlvN PF07991.12 CDK98057.1 - 0.016 14.8 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Response_reg PF00072.24 CDK98058.1 - 4.8e-22 78.2 0.0 6.7e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 CDK98058.1 - 1.5e-20 72.4 0.1 3.9e-20 71.1 0.0 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDK98058.1 - 1.4e-08 34.3 0.0 2.3e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 CDK98058.1 - 1.7e-06 27.5 0.1 3e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 CDK98058.1 - 0.00026 20.7 0.1 0.0021 17.8 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.6 CDK98058.1 - 0.0011 18.7 0.0 0.0035 17.1 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_11 PF08279.12 CDK98058.1 - 0.019 14.9 0.0 0.047 13.6 0.0 1.8 1 0 0 1 1 1 0 HTH domain HTH_24 PF13412.6 CDK98058.1 - 0.026 14.1 0.0 0.059 12.9 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 CDK98058.1 - 0.052 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_40 PF14493.6 CDK98058.1 - 0.052 14.0 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 CDK98058.1 - 0.054 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_10 PF04967.12 CDK98058.1 - 0.18 11.6 0.0 0.77 9.6 0.0 1.9 2 0 0 2 2 2 0 HTH DNA binding domain HATPase_c PF02518.26 CDK98059.1 - 6.2e-28 97.6 0.0 5.2e-17 62.4 0.0 2.5 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 CDK98059.1 - 8.8e-27 93.2 0.0 9.9e-19 67.4 0.0 2.8 2 0 0 2 2 2 2 PAS fold PAS_7 PF12860.7 CDK98059.1 - 4.9e-23 81.5 0.1 4.3e-22 78.4 0.0 2.6 2 1 1 3 3 3 1 PAS fold PAS_4 PF08448.10 CDK98059.1 - 2e-18 66.6 3.6 3.9e-14 52.8 0.0 4.6 4 2 0 4 4 4 2 PAS fold Response_reg PF00072.24 CDK98059.1 - 7.3e-18 64.8 0.3 7.1e-16 58.4 0.1 2.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CDK98059.1 - 5.2e-15 55.2 4.9 1.1e-07 31.7 0.3 3.1 3 0 0 3 3 3 2 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CDK98059.1 - 1.5e-14 53.9 0.0 9.1e-12 45.0 0.0 2.9 3 0 0 3 3 3 2 PAS fold PAS_9 PF13426.7 CDK98059.1 - 1.4e-12 47.8 0.0 2.4e-08 34.2 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.7 CDK98059.1 - 9.1e-06 25.6 0.0 0.025 14.6 0.0 3.7 3 0 0 3 3 3 1 PAS domain HATPase_c_3 PF13589.6 CDK98059.1 - 1.9e-05 24.5 0.0 0.0094 15.8 0.0 2.3 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CDK98059.1 - 0.00024 21.0 0.0 0.0014 18.5 0.0 2.2 2 0 0 2 2 2 1 GHKL domain DUF4350 PF14258.6 CDK98059.1 - 0.081 13.4 0.3 5.6 7.5 0.1 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4350) DPBB_1 PF03330.18 CDK98059.1 - 0.1 12.9 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Lytic transglycolase HATPase_c PF02518.26 CDK98060.1 - 4.4e-19 69.0 0.0 8.5e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 CDK98060.1 - 8.5e-08 32.5 0.6 8.5e-08 32.5 0.6 3.3 2 1 1 3 3 3 1 HAMP domain HisKA PF00512.25 CDK98060.1 - 4.1e-07 29.9 1.5 4.1e-07 29.9 1.5 2.5 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 CDK98060.1 - 0.00029 20.8 0.0 0.00076 19.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HPTransfase PF10090.9 CDK98060.1 - 0.0041 16.9 0.0 0.015 15.1 0.0 1.9 1 0 0 1 1 1 1 Histidine phosphotransferase C-terminal domain DUF948 PF06103.11 CDK98060.1 - 0.0076 16.5 0.1 0.22 11.8 0.0 2.7 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF948) DUF4164 PF13747.6 CDK98060.1 - 0.02 15.2 2.6 2 8.8 0.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) DUF1640 PF07798.11 CDK98060.1 - 0.091 12.8 0.5 0.15 12.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF5063 PF16702.5 CDK98060.1 - 0.17 12.3 0.1 0.36 11.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5063) Prominin PF05478.11 CDK98060.1 - 0.21 9.5 0.0 0.27 9.1 0.0 1.1 1 0 0 1 1 1 0 Prominin Trans_reg_C PF00486.28 CDK98061.1 - 1.6e-28 98.6 1.2 1.9e-28 98.4 0.1 1.7 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 CDK98061.1 - 1.4e-24 86.4 0.0 3.9e-24 85.0 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain 4HBT PF03061.22 CDK98063.1 - 1.6e-17 63.6 1.1 2.2e-17 63.1 1.1 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 CDK98063.1 - 8.3e-05 22.9 0.1 9.5e-05 22.8 0.1 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily MaoC_dehydratas PF01575.19 CDK98063.1 - 0.0033 17.0 0.4 0.0055 16.3 0.3 1.5 1 1 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CDK98063.1 - 0.039 14.1 0.0 0.05 13.8 0.0 1.3 1 0 0 1 1 1 0 N-terminal half of MaoC dehydratase 4HBT_2 PF13279.6 CDK98063.1 - 0.043 14.3 0.0 0.049 14.1 0.0 1.1 1 0 0 1 1 1 0 Thioesterase-like superfamily DNA_gyraseB PF00204.25 CDK98064.1 - 1.3e-43 148.4 0.0 2.1e-43 147.8 0.0 1.3 1 0 0 1 1 1 1 DNA gyrase B DNA_gyraseB_C PF00986.21 CDK98064.1 - 7.6e-24 83.7 0.1 2e-23 82.3 0.1 1.8 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 CDK98064.1 - 2.1e-17 63.6 0.0 4.9e-17 62.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CDK98064.1 - 3e-17 62.7 0.0 6.3e-17 61.7 0.0 1.5 1 0 0 1 1 1 1 Toprim domain HATPase_c_3 PF13589.6 CDK98064.1 - 0.079 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TauE PF01925.19 CDK98065.1 - 1.8e-22 80.1 33.4 2.1e-22 79.9 33.4 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE BTP PF05232.12 CDK98065.1 - 1.2 9.3 11.6 1.6 8.8 0.2 3.3 3 1 0 3 3 3 0 Chlorhexidine efflux transporter FAM70 PF14967.6 CDK98065.1 - 7.1 6.0 6.3 2.5 7.5 3.2 1.7 2 0 0 2 2 2 0 FAM70 protein TauE PF01925.19 CDK98066.1 - 1e-05 25.3 3.9 1.1e-05 25.2 3.9 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE NTP_transferase PF00483.23 CDK98067.1 - 1.4e-64 218.1 0.0 1.7e-64 217.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CDK98067.1 - 6.1e-09 36.4 0.0 1.1e-08 35.6 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 CDK98067.1 - 0.087 11.7 0.3 0.2 10.6 0.0 1.6 2 0 0 2 2 2 0 L-fucokinase Hexapep PF00132.24 CDK98067.1 - 0.14 11.9 1.8 0.91 9.4 0.3 2.8 2 1 1 3 3 3 0 Bacterial transferase hexapeptide (six repeats) Glyco_transf_5 PF08323.11 CDK98068.1 - 1.2e-80 270.7 0.0 2.7e-80 269.6 0.0 1.5 2 0 0 2 2 2 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 CDK98068.1 - 5.3e-13 48.9 0.0 8e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDK98068.1 - 6.6e-13 49.4 2.7 1.8e-12 48.0 2.7 1.8 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 CDK98068.1 - 6.9e-12 46.0 0.0 1.2e-11 45.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDK98068.1 - 2.1e-09 37.6 1.0 3.9e-08 33.5 1.0 2.4 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glucokinase PF02685.16 CDK98069.1 - 1.1e-106 356.4 0.5 1.3e-106 356.1 0.5 1.0 1 0 0 1 1 1 1 Glucokinase cNMP_binding PF00027.29 CDK98071.1 - 4.8e-17 61.8 0.1 1.9e-10 40.7 0.0 2.9 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Hemerythrin PF01814.23 CDK98071.1 - 4.5e-11 43.5 3.5 8.3e-11 42.6 3.5 1.4 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Lactamase_B_2 PF12706.7 CDK98071.1 - 6.4e-10 38.9 0.2 2e-09 37.3 0.1 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDK98071.1 - 3.9e-08 33.5 0.8 1.2e-07 31.9 0.8 1.8 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF309 PF03745.14 CDK98071.1 - 0.026 14.2 0.2 0.06 13.0 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF309) HI0933_like PF03486.14 CDK98072.1 - 2.8e-101 339.2 0.0 3.4e-101 338.9 0.0 1.1 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 CDK98072.1 - 1.5e-07 31.0 0.3 2.2e-07 30.5 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CDK98072.1 - 3.3e-07 29.8 0.2 1.3e-05 24.6 0.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDK98072.1 - 1.4e-06 28.2 2.1 0.011 15.4 0.3 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 CDK98072.1 - 4.4e-06 26.1 0.0 6.8e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CDK98072.1 - 5.5e-06 25.7 1.1 3e-05 23.3 0.1 2.4 3 0 0 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.6 CDK98072.1 - 1.3e-05 25.3 0.9 5.4e-05 23.3 0.1 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CDK98072.1 - 0.0014 18.0 0.1 0.0041 16.5 0.0 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 CDK98072.1 - 0.0015 17.6 0.2 0.0028 16.8 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 CDK98072.1 - 0.0016 18.9 0.1 0.0039 17.7 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDK98072.1 - 0.0041 16.2 1.9 0.03 13.4 0.3 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 CDK98072.1 - 0.011 15.2 0.9 0.011 15.2 0.9 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CDK98072.1 - 0.042 12.7 0.1 0.065 12.1 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 CDK98072.1 - 0.042 13.1 0.2 0.063 12.5 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDK98072.1 - 0.043 13.8 0.8 0.23 11.4 0.8 2.2 1 1 0 1 1 1 0 FAD-NAD(P)-binding SLBB PF10531.9 CDK98072.1 - 0.11 12.3 0.0 2.7 7.9 0.0 2.5 2 0 0 2 2 2 0 SLBB domain Lactamase_B_3 PF13483.6 CDK98073.1 - 8.2e-12 45.3 0.0 1.1e-11 44.9 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CDK98073.1 - 3e-07 30.2 1.3 9.4e-07 28.5 1.3 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain ACR_tran PF00873.19 CDK98074.1 - 3.5e-147 491.8 2.9 4.6e-147 491.4 2.9 1.1 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family SecD_SecF PF02355.16 CDK98074.1 - 4.8e-08 32.6 23.7 6.4e-05 22.4 6.9 2.3 2 0 0 2 2 2 2 Protein export membrane protein HlyD_3 PF13437.6 CDK98075.1 - 1.4e-15 57.9 1.7 6.7e-10 39.6 0.2 3.0 2 1 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CDK98075.1 - 1.4e-15 57.1 1.0 2.1e-15 56.5 1.0 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK98075.1 - 1.1e-12 47.6 5.2 1e-05 25.3 0.0 3.5 4 0 0 4 4 4 2 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK98075.1 - 3e-07 30.2 2.5 0.018 14.8 0.1 3.6 3 0 0 3 3 3 2 Biotin-requiring enzyme Peptidase_M23 PF01551.22 CDK98075.1 - 3.1e-05 24.1 0.3 0.21 11.8 0.1 2.6 2 0 0 2 2 2 2 Peptidase family M23 QRPTase_N PF02749.16 CDK98075.1 - 0.015 15.4 1.6 0.51 10.4 0.2 2.8 2 1 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain PYNP_C PF07831.13 CDK98075.1 - 0.42 10.3 2.6 12 5.6 0.0 3.7 3 1 1 4 4 4 0 Pyrimidine nucleoside phosphorylase C-terminal domain DUF2892 PF11127.8 CDK98076.1 - 2.5e-14 53.0 2.6 3e-14 52.8 2.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2892) Peptidase_M48 PF01435.18 CDK98077.1 - 7.7e-34 117.2 0.0 1e-33 116.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M48 Reprolysin_3 PF13582.6 CDK98077.1 - 0.035 14.6 0.0 0.16 12.5 0.0 1.9 1 1 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 CDK98077.1 - 0.045 13.9 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M78 PF06114.13 CDK98077.1 - 0.059 13.3 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 IrrE N-terminal-like domain FAST_1 PF06743.15 CDK98077.1 - 0.063 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 Hemerythrin PF01814.23 CDK98079.1 - 2.1e-06 28.4 10.7 2.5e-06 28.2 10.7 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain SF-assemblin PF06705.11 CDK98079.1 - 0.01 15.2 0.1 0.021 14.2 0.1 1.5 2 0 0 2 2 2 0 SF-assemblin/beta giardin Peripla_BP_6 PF13458.6 CDK98080.1 - 1.1e-53 183.1 0.0 1.3e-53 182.9 0.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein Peripla_BP_5 PF13433.6 CDK98080.1 - 1e-18 67.5 0.0 3.3e-14 52.7 0.0 2.1 2 0 0 2 2 2 2 Periplasmic binding protein domain ANF_receptor PF01094.28 CDK98080.1 - 8.4e-15 54.7 0.0 2.3e-14 53.3 0.0 1.6 1 1 0 1 1 1 1 Receptor family ligand binding region polyprenyl_synt PF00348.17 CDK98081.1 - 1.1e-73 247.5 0.0 1.4e-73 247.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase MTS PF05175.14 CDK98082.1 - 3.2e-11 43.0 0.0 2.4e-10 40.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDK98082.1 - 5.4e-08 32.8 0.0 6.6e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK98082.1 - 2.1e-06 28.3 0.1 6.7e-06 26.7 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK98082.1 - 0.00012 22.7 0.1 0.00058 20.5 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 CDK98082.1 - 0.00019 20.8 0.0 0.00026 20.4 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_23 PF13489.6 CDK98082.1 - 0.001 19.0 0.0 0.007 16.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK98082.1 - 0.0025 18.5 0.1 0.027 15.2 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 CDK98082.1 - 0.0066 16.0 0.1 0.0096 15.5 0.1 1.1 1 0 0 1 1 1 1 Histone methylation protein DOT1 UPF0020 PF01170.18 CDK98082.1 - 0.011 15.4 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 PCMT PF01135.19 CDK98082.1 - 0.018 14.8 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 CDK98082.1 - 0.02 14.9 0.0 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 CDK98082.1 - 0.034 13.9 0.1 0.049 13.4 0.1 1.2 1 0 0 1 1 1 0 Lysine methyltransferase MetW PF07021.12 CDK98082.1 - 0.061 12.9 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Cons_hypoth95 PF03602.15 CDK98082.1 - 0.08 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PrmA PF06325.13 CDK98082.1 - 0.13 11.6 0.1 0.56 9.5 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) LexA_DNA_bind PF01726.16 CDK98084.1 - 3.1e-14 52.5 0.2 1.6e-12 47.0 0.1 2.3 2 0 0 2 2 2 1 LexA DNA binding domain Peptidase_S24 PF00717.23 CDK98084.1 - 2.6e-12 46.5 0.0 4.3e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like MarR_2 PF12802.7 CDK98084.1 - 0.0068 16.3 0.1 0.014 15.3 0.1 1.6 1 0 0 1 1 1 1 MarR family MarR PF01047.22 CDK98084.1 - 0.017 15.0 0.1 0.043 13.7 0.1 1.7 1 1 0 1 1 1 0 MarR family HTH_IclR PF09339.10 CDK98084.1 - 0.032 14.1 0.0 0.074 12.9 0.0 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF1967 PF09269.11 CDK98084.1 - 0.52 10.3 1.6 3.6 7.6 0.1 2.8 3 1 1 4 4 4 0 Domain of unknown function (DUF1967) MoaC PF01967.21 CDK98085.1 - 3.3e-58 195.6 3.7 3.7e-58 195.4 3.7 1.0 1 0 0 1 1 1 1 MoaC family IGPS PF00218.21 CDK98086.1 - 8.8e-93 310.1 0.0 9.9e-93 310.0 0.0 1.0 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase His_biosynth PF00977.21 CDK98086.1 - 0.0026 17.2 0.0 0.018 14.5 0.0 2.0 2 0 0 2 2 2 1 Histidine biosynthesis protein Glycos_transf_3 PF00591.21 CDK98087.1 - 2.7e-96 322.1 1.0 3.9e-96 321.5 1.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 CDK98087.1 - 2.9e-19 68.6 1.2 8.8e-19 67.1 1.2 1.9 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain GATase PF00117.28 CDK98088.1 - 8.7e-56 188.7 0.0 1e-55 188.4 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CDK98088.1 - 2.6e-14 53.5 0.0 6.1e-14 52.3 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 MCPsignal PF00015.21 CDK98089.1 - 7e-23 81.3 21.9 1.8e-22 79.9 13.4 2.3 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 CDK98089.1 - 0.0004 20.4 5.3 0.26 11.3 0.0 3.3 2 1 1 3 3 3 2 Protein of unknown function (DUF1664) DUF3829 PF12889.7 CDK98089.1 - 0.0068 15.9 0.3 0.051 13.0 0.1 2.3 2 1 1 3 3 3 1 Protein of unknown function (DUF3829) DUF948 PF06103.11 CDK98089.1 - 0.012 15.8 12.9 2 8.7 0.8 4.6 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Tropomyosin PF00261.20 CDK98089.1 - 0.053 12.9 0.0 0.14 11.5 0.0 1.6 1 1 0 1 1 1 0 Tropomyosin NPV_P10 PF05531.12 CDK98089.1 - 0.063 13.7 8.3 5.6 7.5 0.1 4.0 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Sec34 PF04136.15 CDK98089.1 - 0.09 12.7 1.2 5.8 6.8 0.2 3.3 1 1 1 3 3 3 0 Sec34-like family BRI3BP PF14965.6 CDK98089.1 - 0.22 11.0 0.8 1.6 8.3 0.3 2.2 1 1 1 2 2 2 0 Negative regulator of p53/TP53 DUF3798 PF12683.7 CDK98089.1 - 0.28 10.6 5.2 0.067 12.6 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3798) Laminin_II PF06009.12 CDK98089.1 - 0.41 10.7 9.0 2.3 8.2 0.6 3.8 1 1 3 4 4 4 0 Laminin Domain II DUF4164 PF13747.6 CDK98089.1 - 1.1 9.6 7.1 17 5.8 0.9 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4164) DASH_Dad2 PF08654.10 CDK98089.1 - 2.1 8.8 5.0 13 6.2 0.1 3.3 2 2 1 3 3 3 0 DASH complex subunit Dad2 E1-E2_ATPase PF00122.20 CDK98090.1 - 1.5e-61 207.1 2.6 1.5e-61 207.1 2.6 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CDK98090.1 - 2.2e-42 145.7 7.3 2.2e-42 145.7 7.3 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CDK98090.1 - 3.1e-27 94.8 0.8 7.3e-13 48.8 0.0 3.0 3 0 0 3 3 3 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CDK98090.1 - 2e-05 24.4 0.7 0.0012 18.6 0.6 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDK98090.1 - 0.0037 17.7 1.0 0.023 15.1 1.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase YscJ_FliF PF01514.17 CDK98090.1 - 0.0038 16.9 0.1 1.5 8.5 0.1 2.8 2 0 0 2 2 2 2 Secretory protein of YscJ/FliF family MerR-DNA-bind PF09278.11 CDK98091.1 - 1.2e-19 70.6 0.5 1.9e-19 70.0 0.5 1.3 1 0 0 1 1 1 1 MerR, DNA binding MerR PF00376.23 CDK98091.1 - 1.8e-17 62.8 0.3 3.4e-17 61.9 0.3 1.5 1 0 0 1 1 1 1 MerR family regulatory protein MerR_1 PF13411.6 CDK98091.1 - 3.3e-17 62.3 0.1 1.3e-16 60.4 0.0 1.8 2 0 0 2 2 2 1 MerR HTH family regulatory protein DUF5082 PF16888.5 CDK98091.1 - 0.15 12.3 0.1 0.23 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) zf-nanos PF05741.13 CDK98091.1 - 0.2 11.9 1.2 0.45 10.8 1.2 1.6 1 0 0 1 1 1 0 Nanos RNA binding domain Polysacc_deac_2 PF04748.13 CDK98092.1 - 6.7e-80 267.3 0.0 8.2e-80 267.0 0.0 1.1 1 0 0 1 1 1 1 Divergent polysaccharide deacetylase 7TMR-DISMED2 PF07696.11 CDK98093.1 - 4.1e-29 101.3 0.1 7.8e-29 100.4 0.1 1.4 1 0 0 1 1 1 1 7TMR-DISM extracellular 2 7TMR-DISM_7TM PF07695.11 CDK98093.1 - 1.4e-20 74.1 30.8 2.2e-20 73.5 30.8 1.3 1 0 0 1 1 1 1 7TM diverse intracellular signalling HATPase_c PF02518.26 CDK98093.1 - 3.3e-19 69.5 0.0 7e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98093.1 - 5.2e-08 32.8 2.2 7.3e-08 32.3 0.4 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 CDK98093.1 - 0.00059 19.8 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 CDK98093.1 - 0.0007 19.5 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 CDK98093.1 - 0.0039 17.0 0.0 0.0089 15.9 0.0 1.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HMA PF00403.26 CDK98094.1 - 5.1e-13 49.3 0.1 5.7e-13 49.1 0.1 1.0 1 0 0 1 1 1 1 Heavy-metal-associated domain Thioredoxin_4 PF13462.6 CDK98095.1 - 1.3e-20 74.2 0.5 6.8e-20 71.9 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin DSBA PF01323.20 CDK98095.1 - 1.1e-18 67.8 4.6 2e-18 66.9 1.1 2.4 2 1 0 2 2 2 1 DSBA-like thioredoxin domain ScsC_N PF18312.1 CDK98095.1 - 1.1e-14 53.9 0.6 3.1e-14 52.5 0.6 1.8 1 0 0 1 1 1 1 Copper resistance protein ScsC N-terminal domain Thioredoxin_2 PF13098.6 CDK98095.1 - 1.3e-09 38.5 0.4 7.9e-09 35.9 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin PF00085.20 CDK98095.1 - 0.00015 21.7 0.2 0.07 13.1 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.6 CDK98095.1 - 0.013 15.5 0.1 0.74 9.9 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin domain Thioredoxin_5 PF13743.6 CDK98095.1 - 0.013 15.2 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_8 PF13905.6 CDK98095.1 - 0.02 15.2 0.0 7.1 7.0 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin-like MHB PF16525.5 CDK98095.1 - 0.14 12.5 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 Haemophore, haem-binding Peptidase_M48 PF01435.18 CDK98096.1 - 2.7e-25 89.3 0.2 4.1e-25 88.7 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M48 TPR_14 PF13428.6 CDK98096.1 - 4.1e-09 36.5 7.1 0.00018 22.1 0.3 5.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDK98096.1 - 1.3e-08 35.3 4.1 3.2e-05 24.5 0.2 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDK98096.1 - 1.5e-08 35.0 10.9 1.3e-05 25.6 0.2 3.7 3 1 1 4 4 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDK98096.1 - 0.013 15.5 0.8 0.054 13.6 0.1 2.2 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 CDK98096.1 - 0.027 14.6 3.0 1.9 8.8 0.4 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF627 PF04781.12 CDK98096.1 - 0.047 13.7 0.0 0.14 12.2 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF627) TPR_6 PF13174.6 CDK98096.1 - 0.047 14.3 4.0 0.096 13.4 0.4 3.3 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDK98096.1 - 0.057 13.1 0.1 5.9 6.7 0.0 3.0 2 0 0 2 2 2 0 TPR repeat TPR_20 PF14561.6 CDK98096.1 - 0.062 13.6 5.5 10 6.5 0.1 4.1 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDK98096.1 - 0.16 12.4 0.6 31 5.2 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat G_glu_transpept PF01019.21 CDK98097.1 - 3.9e-68 230.5 6.3 6.3e-57 193.5 3.7 2.9 2 1 0 2 2 2 2 Gamma-glutamyltranspeptidase GGDEF PF00990.21 CDK98098.1 - 1.4e-43 148.4 0.2 2.2e-43 147.8 0.2 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain SBP_bac_3 PF00497.20 CDK98098.1 - 1.4e-27 96.6 0.0 2.1e-26 92.7 0.0 2.1 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 Sugarporin_N PF11471.8 CDK98098.1 - 0.061 13.3 0.7 3.2 7.8 0.5 2.7 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension GGDEF_2 PF17853.1 CDK98098.1 - 0.094 13.0 0.4 0.29 11.4 0.1 2.0 2 0 0 2 2 2 0 GGDEF-like domain Porin_4 PF13609.6 CDK98099.1 - 2.7e-34 119.4 10.1 3.3e-34 119.1 10.1 1.0 1 0 0 1 1 1 1 Gram-negative porin Aminotran_1_2 PF00155.21 CDK98100.1 - 5.6e-52 177.1 0.0 6.4e-52 176.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CDK98100.1 - 0.00045 19.1 0.0 0.001 17.9 0.0 1.5 2 0 0 2 2 2 1 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.17 CDK98100.1 - 0.0023 17.3 0.3 0.0033 16.8 0.3 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family DUF4065 PF13274.6 CDK98102.1 - 0.012 16.5 0.0 0.077 13.9 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4065) OMP_b-brl PF13505.6 CDK98103.1 - 3.8e-19 69.5 8.2 4.6e-19 69.2 8.2 1.1 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OMP_b-brl_2 PF13568.6 CDK98103.1 - 0.00025 21.1 1.2 0.0018 18.3 0.1 2.1 2 0 0 2 2 2 1 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CDK98103.1 - 0.0041 16.9 0.5 0.013 15.3 0.0 1.8 2 0 0 2 2 2 1 OmpA-like transmembrane domain DUF455 PF04305.14 CDK98104.1 - 6.7e-95 317.3 0.0 7.8e-95 317.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Phenol_Hydrox PF02332.18 CDK98104.1 - 0.033 13.7 0.0 0.061 12.8 0.0 1.5 1 0 0 1 1 1 0 Methane/Phenol/Toluene Hydroxylase AhpC-TSA PF00578.21 CDK98105.1 - 8.8e-37 125.8 0.0 1e-36 125.6 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDK98105.1 - 7e-19 68.0 0.0 7.7e-19 67.9 0.0 1.0 1 0 0 1 1 1 1 Redoxin DUF899 PF05988.12 CDK98105.1 - 0.00026 20.6 0.0 0.0003 20.4 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) AhpC-TSA_2 PF13911.6 CDK98105.1 - 0.00033 20.8 0.0 0.001 19.2 0.0 1.6 1 1 1 2 2 2 1 AhpC/TSA antioxidant enzyme GlnE PF03710.15 CDK98106.1 - 1.9e-126 420.6 5.1 6.3e-64 215.8 0.1 2.9 4 0 0 4 4 4 2 Glutamate-ammonia ligase adenylyltransferase GlnD_UR_UTase PF08335.11 CDK98106.1 - 4.4e-53 179.3 5.6 1.1e-41 142.3 0.6 3.0 3 0 0 3 3 3 2 GlnD PII-uridylyltransferase DUF294_C PF10335.9 CDK98106.1 - 1.8e-07 31.1 0.7 0.014 15.2 0.1 2.6 2 0 0 2 2 2 2 Putative nucleotidyltransferase substrate binding domain DUF294 PF03445.13 CDK98106.1 - 2.5e-07 30.6 0.0 2.3e-06 27.5 0.0 2.4 2 0 0 2 2 2 1 Putative nucleotidyltransferase DUF294 NTP_transf_2 PF01909.23 CDK98106.1 - 0.13 12.5 0.0 2 8.8 0.0 2.3 2 0 0 2 2 2 0 Nucleotidyltransferase domain Polbeta PF18765.1 CDK98106.1 - 0.13 12.3 0.1 1.3 9.2 0.0 2.5 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase AsmA_2 PF13502.6 CDK98107.1 - 1.2e-19 70.8 6.2 2.4e-19 69.8 1.2 3.7 3 1 1 4 4 4 1 AsmA-like C-terminal region DUF3971 PF13116.6 CDK98107.1 - 6.5e-14 52.2 0.0 2.5e-13 50.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function AsmA_1 PF13109.6 CDK98107.1 - 6.6e-07 29.0 0.0 1.2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 AsmA-like C-terminal region AsmA PF05170.14 CDK98107.1 - 0.044 12.6 0.0 0.17 10.7 0.0 2.0 2 0 0 2 2 2 0 AsmA family tRNA-synt_1b PF00579.25 CDK98108.1 - 8.4e-71 238.7 0.0 1.1e-70 238.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 CDK98108.1 - 0.016 14.9 0.0 0.039 13.7 0.0 1.6 1 0 0 1 1 1 0 S4 domain gpD PF02925.16 CDK98108.1 - 0.15 12.0 0.0 0.4 10.7 0.0 1.6 2 0 0 2 2 2 0 Bacteriophage scaffolding protein D AnmK PF03702.14 CDK98109.1 - 2.5e-94 316.4 2.8 3e-94 316.2 2.8 1.0 1 0 0 1 1 1 1 Anhydro-N-acetylmuramic acid kinase FGGY_C PF02782.16 CDK98109.1 - 0.0019 18.0 0.1 0.0035 17.1 0.1 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain PhoU PF01895.19 CDK98111.1 - 3.2e-41 139.7 14.9 1.2e-20 73.7 3.4 2.5 2 1 1 3 3 3 2 PhoU domain MutS_III PF05192.18 CDK98111.1 - 0.14 12.4 0.4 0.26 11.5 0.4 1.5 1 1 0 1 1 1 0 MutS domain III DUF5631 PF18645.1 CDK98111.1 - 0.43 11.0 3.1 2 8.8 0.3 2.8 1 1 2 3 3 3 0 Family of unknown function (DUF5631) ABC_tran PF00005.27 CDK98112.1 - 1.2e-29 103.5 0.0 1.8e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98112.1 - 3.2e-12 46.9 0.1 5.5e-05 23.1 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK98112.1 - 3.6e-07 29.8 0.0 0.0017 17.8 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDK98112.1 - 0.0001 22.8 0.0 0.0002 21.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CDK98112.1 - 0.00023 21.0 0.0 0.00094 19.0 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CDK98112.1 - 0.00023 21.1 0.0 0.0005 20.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CDK98112.1 - 0.00029 20.5 0.0 0.00059 19.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDK98112.1 - 0.0024 18.3 0.0 0.0058 17.0 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 CDK98112.1 - 0.0029 17.6 0.0 0.0061 16.5 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 CDK98112.1 - 0.003 17.8 0.1 0.0083 16.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CDK98112.1 - 0.013 15.2 0.2 0.41 10.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDK98112.1 - 0.015 14.9 0.0 0.14 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDK98112.1 - 0.026 14.7 0.0 0.053 13.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CDK98112.1 - 0.076 13.6 0.1 0.25 11.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CDK98112.1 - 0.077 12.7 0.1 0.36 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDK98112.1 - 0.12 12.6 0.1 0.43 10.8 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CDK98112.1 - 0.13 12.7 0.5 2.6 8.5 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CobN-Mg_chel PF02514.16 CDK98113.1 - 0 1296.2 0.0 0 1296.0 0.0 1.0 1 0 0 1 1 1 1 CobN/Magnesium Chelatase cobW PF02492.19 CDK98114.1 - 2e-57 193.6 0.0 2.6e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 CDK98114.1 - 1.8e-19 69.4 0.1 3.1e-19 68.7 0.1 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_22 PF13401.6 CDK98114.1 - 0.011 16.0 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDK98114.1 - 0.012 15.6 0.1 0.029 14.4 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CDK98114.1 - 0.012 16.1 0.0 0.026 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDK98114.1 - 0.013 15.4 0.0 0.54 10.1 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_28 PF13521.6 CDK98114.1 - 0.015 15.6 0.0 0.035 14.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain Arf PF00025.21 CDK98114.1 - 0.016 14.7 0.1 5.5 6.4 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDK98114.1 - 0.016 14.7 0.1 5.4 6.5 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CDK98114.1 - 0.018 15.4 0.7 0.052 13.9 0.0 2.1 2 1 1 3 3 3 0 AAA ATPase domain AAA_33 PF13671.6 CDK98114.1 - 0.024 14.8 0.0 0.05 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 CDK98114.1 - 0.044 13.5 0.0 0.065 13.0 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 CDK98114.1 - 0.047 12.7 0.2 0.67 8.9 0.1 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 CDK98114.1 - 0.075 12.9 0.1 0.33 10.9 0.0 1.9 2 0 0 2 2 2 0 NACHT domain MobB PF03205.14 CDK98114.1 - 0.14 12.1 0.0 0.34 10.8 0.0 1.7 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ATPase_2 PF01637.18 CDK98114.1 - 0.2 11.5 0.0 0.31 10.9 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 CDK98114.1 - 0.26 11.3 0.1 0.43 10.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain CobU PF02283.16 CDK98115.1 - 3.4e-57 192.7 0.0 3.8e-57 192.5 0.0 1.0 1 0 0 1 1 1 1 Cobinamide kinase / cobinamide phosphate guanyltransferase Fe-ADH PF00465.19 CDK98116.1 - 5.4e-90 301.8 0.8 6.7e-90 301.5 0.8 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CDK98116.1 - 3e-12 46.8 0.1 1.2e-06 28.4 0.0 2.4 2 1 0 2 2 2 2 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 CDK98116.1 - 0.007 15.6 0.4 0.19 10.8 0.0 2.8 3 0 0 3 3 3 1 3-dehydroquinate synthase HATPase_c PF02518.26 CDK98117.1 - 1.4e-24 86.7 0.0 2.9e-24 85.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 CDK98117.1 - 6.7e-11 42.4 0.0 1.9e-10 41.0 0.0 1.7 2 0 0 2 2 2 1 Cache domain HisKA PF00512.25 CDK98117.1 - 7.6e-10 38.7 0.3 2.5e-09 37.0 0.0 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CDK98117.1 - 0.00062 19.6 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 CDK98117.1 - 0.15 12.0 0.0 0.47 10.4 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain SBP_bac_3 PF00497.20 CDK98118.1 - 8.7e-35 120.2 0.0 1e-34 120.0 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 CDK98118.1 - 0.017 15.3 0.0 0.14 12.4 0.0 2.1 1 1 1 2 2 2 0 Ligated ion channel L-glutamate- and glycine-binding site Peptidase_M22 PF00814.25 CDK98119.1 - 2.9e-99 332.2 0.6 3.3e-99 332.0 0.6 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 CDK98119.1 - 0.16 11.6 0.0 0.73 9.4 0.0 2.0 1 1 0 2 2 2 0 Carbamoyltransferase N-terminus Porphobil_deam PF01379.20 CDK98120.1 - 3.3e-77 258.6 0.1 4.7e-77 258.1 0.1 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 CDK98120.1 - 2.3e-16 59.9 0.0 3.9e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain HEM4 PF02602.15 CDK98121.1 - 7.9e-34 117.0 1.7 9.2e-34 116.8 1.7 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Mitofilin PF09731.9 CDK98122.1 - 3.7e-17 62.4 14.8 6.4e-17 61.6 14.7 1.4 1 1 0 1 1 1 1 Mitochondrial inner membrane protein Seryl_tRNA_N PF02403.22 CDK98122.1 - 0.13 12.5 4.6 0.38 11.0 2.4 2.6 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DASH_Dad2 PF08654.10 CDK98122.1 - 0.17 12.3 2.1 0.65 10.5 0.7 2.4 2 0 0 2 2 2 0 DASH complex subunit Dad2 DUF1993 PF09351.10 CDK98122.1 - 0.46 10.6 3.9 0.31 11.1 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) HemY_N PF07219.13 CDK98123.1 - 1e-27 96.4 4.3 1e-27 96.4 4.3 4.9 4 2 1 5 5 5 1 HemY protein N-terminus TPR_19 PF14559.6 CDK98123.1 - 4.2e-06 27.2 30.6 0.0046 17.4 1.2 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat Rubredoxin_2 PF18073.1 CDK98123.1 - 0.013 15.2 3.5 0.024 14.3 3.5 1.4 1 0 0 1 1 1 0 Rubredoxin metal binding domain DZR PF12773.7 CDK98123.1 - 0.082 12.9 0.9 0.14 12.2 0.9 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 CDK98123.1 - 0.24 10.9 4.0 0.42 10.1 4.0 1.3 1 0 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 CDK98123.1 - 0.33 11.1 0.7 0.77 9.9 0.7 1.6 1 0 0 1 1 1 0 Zinc ribbon domain zf-NADH-PPase PF09297.11 CDK98123.1 - 7 6.4 9.1 9.3 6.0 1.0 2.4 1 1 1 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Frataxin_Cyay PF01491.16 CDK98124.1 - 1.6e-27 95.7 0.0 1.8e-27 95.6 0.0 1.0 1 0 0 1 1 1 1 Frataxin-like domain Response_reg PF00072.24 CDK98125.1 - 2.7e-08 33.9 0.0 0.0002 21.5 0.0 2.1 2 0 0 2 2 2 2 Response regulator receiver domain Ribosomal_L31 PF01197.18 CDK98126.1 - 4.1e-27 94.2 0.1 4.6e-27 94.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L31 Guanylate_cyc PF00211.20 CDK98127.1 - 5.4e-16 58.7 0.3 8.9e-16 58.0 0.3 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF1465 PF07323.12 CDK98128.1 - 2.6e-29 102.1 5.2 2.8e-29 102.0 5.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1465) DUF4044 PF13253.6 CDK98128.1 - 0.23 11.0 0.5 0.38 10.3 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) 4HBT_2 PF13279.6 CDK98130.1 - 8.8e-12 45.6 0.0 1.2e-11 45.1 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 CDK98130.1 - 7.2e-10 39.1 0.0 9.9e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 CDK98130.1 - 1.1e-06 28.1 0.0 7.7e-05 22.1 0.0 2.0 2 0 0 2 2 2 2 Acyl-ACP thioesterase adh_short_C2 PF13561.6 CDK98131.1 - 7e-56 189.4 1.6 1.2e-55 188.7 1.6 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDK98131.1 - 1.2e-50 171.7 1.1 1.2e-50 171.7 1.1 1.3 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CDK98131.1 - 1.6e-08 34.7 1.1 2.9e-08 33.8 1.1 1.4 1 0 0 1 1 1 1 KR domain DUF1192 PF06698.11 CDK98132.1 - 1.4e-21 76.3 1.8 1.6e-21 76.1 1.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) KASH_CCD PF14662.6 CDK98132.1 - 0.046 13.5 0.1 0.046 13.5 0.1 1.0 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH ADH_zinc_N PF00107.26 CDK98133.1 - 3.4e-31 107.9 0.8 5.2e-31 107.3 0.8 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDK98133.1 - 1.1e-29 104.2 0.1 2e-29 103.3 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDK98133.1 - 3.5e-09 36.5 0.1 7.9e-08 32.2 0.0 2.5 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 CDK98133.1 - 0.011 15.0 0.4 0.019 14.3 0.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 CDK98133.1 - 0.1 12.1 0.7 0.19 11.2 0.7 1.5 1 0 0 1 1 1 0 short chain dehydrogenase DUF1013 PF06242.11 CDK98134.1 - 7.8e-65 217.1 0.0 1.2e-64 216.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1013) HTH_Tnp_ISL3 PF13542.6 CDK98134.1 - 0.033 13.6 0.1 0.29 10.6 0.0 2.3 4 0 0 4 4 4 0 Helix-turn-helix domain of transposase family ISL3 ACR_tran PF00873.19 CDK98135.1 - 3.1e-266 885.9 25.8 3.5e-266 885.8 25.8 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 CDK98135.1 - 1.8e-13 50.2 37.2 4.9e-08 32.3 16.7 2.4 2 0 0 2 2 2 2 MMPL family SecD_SecF PF02355.16 CDK98135.1 - 0.0041 16.5 8.9 0.0041 16.5 8.9 2.7 3 0 0 3 3 3 2 Protein export membrane protein DUF1471 PF07338.13 CDK98135.1 - 0.14 12.2 0.0 0.45 10.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1471) HlyD_D23 PF16576.5 CDK98136.1 - 5.8e-27 94.3 2.1 1.2e-26 93.3 2.1 1.6 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CDK98136.1 - 2.9e-16 60.1 5.4 8.9e-13 48.9 0.1 3.2 3 1 0 3 3 3 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDK98136.1 - 6.7e-10 38.6 1.0 6.7e-10 38.6 1.0 3.2 3 0 0 3 3 3 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK98136.1 - 0.0032 17.3 6.6 0.031 14.1 0.1 3.7 5 0 0 5 5 5 2 Biotin-requiring enzyme HlyD PF00529.20 CDK98136.1 - 0.026 14.4 10.8 1.2 9.1 1.2 3.0 2 1 0 2 2 2 0 HlyD membrane-fusion protein of T1SS TetR_C_28 PF17937.1 CDK98137.1 - 9.5e-16 58.0 0.0 2e-15 57.0 0.0 1.6 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 CDK98137.1 - 5.8e-11 42.0 0.1 9e-11 41.4 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_31 PF17940.1 CDK98137.1 - 0.00079 19.6 0.1 0.037 14.2 0.0 2.3 1 1 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain ABC_tran PF00005.27 CDK98138.1 - 4.3e-29 101.8 0.0 5.8e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98138.1 - 2.8e-09 37.2 0.0 0.0019 18.1 0.4 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK98138.1 - 3.2e-07 30.0 0.0 0.0037 16.7 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDK98138.1 - 0.00027 21.3 1.6 0.00088 19.7 1.6 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDK98138.1 - 0.00051 19.7 0.1 0.00091 18.9 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CDK98138.1 - 0.0012 18.5 1.7 0.076 12.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CDK98138.1 - 0.0017 18.6 0.4 0.039 14.2 0.4 2.3 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 CDK98138.1 - 0.034 14.1 0.1 5.1 7.0 0.0 2.1 2 0 0 2 2 2 0 NTPase AAA_23 PF13476.6 CDK98138.1 - 0.05 14.1 0.0 0.076 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDK98138.1 - 0.06 13.1 0.1 0.16 11.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDK98138.1 - 0.072 13.0 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase IstB_IS21 PF01695.17 CDK98138.1 - 0.085 12.6 0.0 1 9.1 0.0 2.2 2 1 0 2 2 2 0 IstB-like ATP binding protein Cytidylate_kin PF02224.18 CDK98138.1 - 0.11 12.2 0.3 0.28 10.9 0.1 1.7 2 0 0 2 2 2 0 Cytidylate kinase AAA_18 PF13238.6 CDK98138.1 - 0.12 13.0 1.0 0.89 10.1 0.3 2.3 2 1 1 3 3 3 0 AAA domain AAA_15 PF13175.6 CDK98138.1 - 0.13 12.0 0.0 5.4 6.6 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 CDK98138.1 - 0.17 12.1 0.5 0.71 10.1 0.0 2.2 2 1 0 2 2 2 0 AAA domain RNA12 PF10443.9 CDK98138.1 - 0.19 10.4 0.0 0.27 9.9 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein MacB_PCD PF12704.7 CDK98139.1 - 2.1e-14 54.3 1.9 4.1e-14 53.4 1.9 1.5 1 0 0 1 1 1 1 MacB-like periplasmic core domain FtsX PF02687.21 CDK98139.1 - 1.6e-12 47.7 0.4 1.6e-12 47.7 0.4 3.3 3 1 0 3 3 3 1 FtsX-like permease family HlyD_D23 PF16576.5 CDK98140.1 - 1.1e-26 93.3 0.1 1.9e-26 92.6 0.1 1.3 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CDK98140.1 - 2.1e-19 70.2 0.1 1.7e-15 57.6 0.0 2.5 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDK98140.1 - 2.9e-09 36.6 0.0 1.2e-08 34.6 0.0 2.1 1 0 0 1 1 1 1 Biotin-lipoyl like HlyD PF00529.20 CDK98140.1 - 8.3e-07 28.8 1.7 1.3e-06 28.2 0.3 2.0 2 0 0 2 2 2 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl PF00364.22 CDK98140.1 - 0.011 15.6 0.0 0.047 13.5 0.0 2.2 1 0 0 1 1 1 0 Biotin-requiring enzyme RnfC_N PF13375.6 CDK98140.1 - 0.026 14.5 0.0 0.12 12.3 0.0 2.2 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Peptidase_M23 PF01551.22 CDK98140.1 - 0.061 13.5 0.4 2.4 8.4 0.1 3.2 3 1 0 3 3 3 0 Peptidase family M23 Aminotran_3 PF00202.21 CDK98142.1 - 2.2e-104 349.4 0.0 2.7e-104 349.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III AAA_26 PF13500.6 CDK98143.1 - 8.3e-58 195.5 0.0 9.9e-58 195.2 0.0 1.0 1 0 0 1 1 1 1 AAA domain Methyltransf_23 PF13489.6 CDK98144.1 - 6.7e-17 61.8 0.0 8.1e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK98144.1 - 6.1e-16 58.9 0.1 1.5e-15 57.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK98144.1 - 4.2e-15 56.2 0.0 7.5e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK98144.1 - 9.7e-12 45.5 0.0 2e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDK98144.1 - 1e-11 44.8 0.0 1.5e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 CDK98144.1 - 1.5e-07 31.3 0.0 2.3e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) PrmA PF06325.13 CDK98144.1 - 4.9e-06 26.1 0.0 6.7e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CDK98144.1 - 9.8e-05 22.0 0.0 0.00035 20.2 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase small domain PCMT PF01135.19 CDK98144.1 - 0.0089 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 CDK98144.1 - 0.15 11.3 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 CDK98144.1 - 0.24 11.4 0.0 0.35 10.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 CDK98144.1 - 0.25 10.4 0.0 0.33 10.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Abhydrolase_6 PF12697.7 CDK98145.1 - 5.1e-07 30.5 16.1 1.9e-05 25.4 16.1 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDK98145.1 - 4.7e-05 23.2 0.1 0.12 12.0 0.0 2.6 3 0 0 3 3 3 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDK98145.1 - 9.2e-05 21.8 0.0 0.00031 20.1 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 TFIID_30kDa PF03540.13 CDK98145.1 - 0.15 12.0 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit Aminotran_1_2 PF00155.21 CDK98146.1 - 5.4e-55 187.0 0.0 6.1e-55 186.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CDK98146.1 - 9.1e-06 24.4 0.0 1.2e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 CDK98146.1 - 0.00092 18.6 0.1 0.0014 18.0 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CDK98146.1 - 0.018 14.4 1.2 0.18 11.1 0.1 2.1 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family SHMT PF00464.19 CDK98146.1 - 0.049 12.2 0.0 0.077 11.6 0.0 1.3 1 0 0 1 1 1 0 Serine hydroxymethyltransferase ASFV_J13L PF05568.11 CDK98146.1 - 0.19 11.5 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein BATS PF06968.13 CDK98148.1 - 3.1e-18 65.7 0.0 6.8e-18 64.6 0.0 1.6 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 CDK98148.1 - 7e-16 59.0 0.1 1.2e-15 58.3 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily EAL PF00563.20 CDK98149.1 - 1.5e-67 227.6 0.0 2.6e-67 226.8 0.0 1.4 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK98149.1 - 1.4e-46 158.2 0.3 2.5e-46 157.4 0.3 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDK98149.1 - 2.4e-23 82.3 0.0 6.8e-14 52.0 0.0 3.1 2 1 0 2 2 2 2 PAS domain PAS PF00989.25 CDK98149.1 - 2.9e-22 78.8 0.0 2.1e-11 43.8 0.0 3.4 3 1 1 4 4 4 2 PAS fold PAS_8 PF13188.7 CDK98149.1 - 8.9e-20 70.3 0.0 1.1e-09 38.1 0.0 3.6 3 0 0 3 3 3 2 PAS domain PAS_4 PF08448.10 CDK98149.1 - 8.7e-18 64.6 0.1 5.1e-09 36.3 0.0 3.0 3 0 0 3 3 3 2 PAS fold PAS_3 PF08447.12 CDK98149.1 - 1e-13 51.3 0.0 9e-13 48.3 0.0 2.4 2 0 0 2 2 2 1 PAS fold Response_reg PF00072.24 CDK98149.1 - 2.5e-10 40.5 0.1 1.3e-09 38.2 0.0 2.3 2 0 0 2 2 2 1 Response regulator receiver domain MLTR_LBD PF17765.1 CDK98149.1 - 0.0023 18.1 0.0 0.69 10.0 0.1 2.8 2 0 0 2 2 2 1 MmyB-like transcription regulator ligand binding domain PAS_7 PF12860.7 CDK98149.1 - 0.013 15.6 0.0 9.8 6.4 0.0 3.5 4 0 0 4 4 4 0 PAS fold Phosphonate-bd PF12974.7 CDK98150.1 - 3.3e-47 161.1 0.1 4.1e-47 160.8 0.1 1.0 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein DUF1938 PF09153.10 CDK98150.1 - 0.0059 16.7 0.0 0.015 15.4 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1938) Lipoprotein_9 PF03180.14 CDK98150.1 - 0.13 11.3 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 NLPA lipoprotein Response_reg PF00072.24 CDK98151.1 - 2.4e-34 117.9 3.2 1.9e-26 92.4 1.2 3.0 3 0 0 3 3 3 2 Response regulator receiver domain HATPase_c PF02518.26 CDK98151.1 - 5.8e-29 100.9 0.0 1.3e-28 99.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98151.1 - 7.5e-20 70.7 0.3 3.9e-19 68.4 0.1 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain dCache_3 PF14827.6 CDK98151.1 - 9.2e-14 51.7 0.0 2.6e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Double sensory domain of two-component sensor kinase PAS_4 PF08448.10 CDK98151.1 - 2.8e-11 43.7 0.0 1.8e-10 41.1 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CDK98151.1 - 1.2e-10 41.6 0.0 3e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 PAS domain Hpt PF01627.23 CDK98151.1 - 1.5e-10 41.2 1.0 6.6e-10 39.1 1.0 2.2 1 0 0 1 1 1 1 Hpt domain PAS PF00989.25 CDK98151.1 - 3.1e-09 36.8 0.0 7.3e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK98151.1 - 3.4e-08 33.3 0.0 1.2e-07 31.5 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS_7 PF12860.7 CDK98151.1 - 3.5e-06 27.2 0.0 0.00014 22.0 0.0 2.7 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 CDK98151.1 - 0.0075 16.5 0.0 0.021 15.1 0.0 1.8 1 0 0 1 1 1 1 PAS fold MFS_1 PF07690.16 CDK98152.1 - 1.3e-30 106.5 53.6 1.3e-30 106.5 53.6 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily XAF1_C PF18608.1 CDK98153.1 - 0.066 12.8 1.5 1.1 8.9 0.1 2.1 1 1 1 2 2 2 0 XIAP-associated factor 1 C-terminal domain Hemerythrin PF01814.23 CDK98154.1 - 4.6e-16 59.6 6.1 5.2e-16 59.5 6.1 1.0 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Exonuc_X-T_C PF08411.10 CDK98154.1 - 0.013 14.7 0.7 0.014 14.5 0.7 1.1 1 0 0 1 1 1 0 Exonuclease C-terminal DUF326 PF03860.16 CDK98156.1 - 0.55 10.3 25.7 0.89 9.6 2.8 3.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF326) Peripla_BP_6 PF13458.6 CDK98158.1 - 4.1e-66 224.0 8.6 4.8e-66 223.8 8.6 1.0 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.28 CDK98158.1 - 1.8e-35 122.7 0.0 2.2e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_5 PF13433.6 CDK98158.1 - 1.6e-20 73.4 0.5 6.8e-20 71.4 0.5 1.9 1 1 0 1 1 1 1 Periplasmic binding protein domain Fe-ADH PF00465.19 CDK98158.1 - 0.021 13.7 0.1 0.049 12.4 0.0 1.6 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase Toprim_3 PF13362.6 CDK98158.1 - 0.032 14.6 0.9 1.2 9.5 0.0 3.1 3 0 0 3 3 3 0 Toprim domain Thi4 PF01946.17 CDK98158.1 - 0.08 12.2 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Thi4 family PGM_PMM_I PF02878.16 CDK98158.1 - 0.12 12.1 1.1 0.46 10.2 0.0 2.3 2 1 1 3 3 3 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Glyco_tran_WecB PF03808.13 CDK98158.1 - 0.17 11.8 0.1 0.76 9.7 0.1 2.1 1 1 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family ABC_tran PF00005.27 CDK98160.1 - 7.4e-29 101.0 0.0 9.8e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98160.1 - 8.3e-12 45.5 0.3 5.4e-06 26.4 0.1 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDK98160.1 - 0.00032 21.1 0.1 0.00072 20.0 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDK98160.1 - 0.0021 17.8 0.0 0.0055 16.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDK98160.1 - 0.0034 17.9 0.0 0.0053 17.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CDK98160.1 - 0.018 14.8 0.0 0.046 13.4 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain SMC_N PF02463.19 CDK98160.1 - 0.019 14.4 0.0 0.66 9.4 0.0 2.2 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDK98160.1 - 0.023 15.0 0.7 0.14 12.5 0.7 2.2 1 1 0 1 1 1 0 AAA domain VirC1 PF07015.11 CDK98160.1 - 0.024 13.9 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 VirC1 protein AAA_25 PF13481.6 CDK98160.1 - 0.027 14.0 0.4 0.049 13.2 0.4 1.8 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CDK98160.1 - 0.028 14.3 0.1 0.065 13.2 0.1 1.7 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 CDK98160.1 - 0.032 14.0 0.2 0.16 11.6 0.1 2.0 2 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CDK98160.1 - 0.045 13.7 0.0 0.084 12.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase cobW PF02492.19 CDK98160.1 - 0.051 13.2 0.1 0.078 12.6 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CDK98160.1 - 0.052 13.7 0.0 0.079 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain BON PF04972.17 CDK98160.1 - 0.058 13.7 0.7 1.8 8.9 0.1 2.8 3 0 0 3 3 3 0 BON domain DUF3584 PF12128.8 CDK98160.1 - 0.061 10.8 0.3 0.08 10.4 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DLIC PF05783.11 CDK98160.1 - 0.1 11.4 0.1 0.14 10.9 0.1 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) SbcCD_C PF13558.6 CDK98160.1 - 0.1 12.8 0.2 0.74 10.1 0.2 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 CDK98160.1 - 0.16 12.1 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 CDK98161.1 - 1.2e-26 93.9 0.0 1.5e-26 93.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter BCA_ABC_TP_C PF12399.8 CDK98161.1 - 7.3e-12 44.9 0.4 1.2e-11 44.2 0.4 1.4 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_21 PF13304.6 CDK98161.1 - 4.3e-07 30.0 0.2 3.7e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDK98161.1 - 4.7e-07 30.5 0.0 6.3e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDK98161.1 - 0.00012 22.0 0.0 0.0002 21.3 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_27 PF13514.6 CDK98161.1 - 0.00062 19.4 0.0 0.001 18.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDK98161.1 - 0.00065 19.4 0.0 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CDK98161.1 - 0.0021 17.6 0.0 0.0031 17.0 0.0 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDK98161.1 - 0.0023 18.2 0.0 0.011 15.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDK98161.1 - 0.0086 16.2 0.0 0.016 15.3 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 CDK98161.1 - 0.011 15.5 0.0 0.029 14.1 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_16 PF13191.6 CDK98161.1 - 0.023 15.1 0.0 0.049 14.0 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 CDK98161.1 - 0.027 14.2 0.0 0.044 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 CDK98161.1 - 0.048 13.2 0.0 0.099 12.2 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_13 PF13166.6 CDK98161.1 - 0.11 11.2 0.0 0.12 11.0 0.0 1.0 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 CDK98161.1 - 0.16 9.4 0.1 0.21 9.1 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ABC_ATPase PF09818.9 CDK98161.1 - 0.23 10.2 0.1 0.65 8.7 0.0 1.6 2 0 0 2 2 2 0 Predicted ATPase of the ABC class BPD_transp_2 PF02653.16 CDK98162.1 - 8.9e-48 162.8 28.4 8.9e-48 162.8 28.4 1.8 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component DUF3382 PF11862.8 CDK98162.1 - 2.8e-14 53.1 3.7 2.8e-14 53.1 3.7 3.1 4 0 0 4 4 4 1 Domain of unknown function (DUF3382) MLTD_N PF06474.12 CDK98162.1 - 0.065 13.4 0.2 0.065 13.4 0.2 3.2 3 0 0 3 3 3 0 MltD lipid attachment motif BPD_transp_2 PF02653.16 CDK98163.1 - 4.1e-50 170.4 41.4 5.1e-50 170.1 41.4 1.1 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component Phageshock_PspD PF09584.10 CDK98163.1 - 0.055 13.5 1.2 0.095 12.7 0.3 2.0 2 0 0 2 2 2 0 Phage shock protein PspD (Phageshock_PspD) Response_reg PF00072.24 CDK98165.1 - 2.3e-24 85.7 1.6 2.6e-24 85.5 1.6 1.0 1 0 0 1 1 1 1 Response regulator receiver domain FleQ PF06490.11 CDK98165.1 - 0.00066 20.0 0.0 0.00089 19.6 0.0 1.1 1 0 0 1 1 1 1 Flagellar regulatory protein FleQ DASH_Dad2 PF08654.10 CDK98165.1 - 0.12 12.8 0.1 0.2 12.1 0.1 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad2 HATPase_c PF02518.26 CDK98166.1 - 8.1e-23 81.1 0.2 1.5e-22 80.2 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_4 PF08448.10 CDK98166.1 - 1.1e-17 64.3 5.5 9e-07 29.1 0.0 4.3 3 1 1 4 4 4 3 PAS fold PAS_9 PF13426.7 CDK98166.1 - 8.2e-16 58.2 0.0 7e-09 35.9 0.0 3.4 3 0 0 3 3 3 3 PAS domain PAS PF00989.25 CDK98166.1 - 4.5e-15 55.6 0.1 2.8e-08 33.8 0.0 4.2 4 0 0 4 4 4 2 PAS fold PAS_8 PF13188.7 CDK98166.1 - 2.4e-13 49.8 0.0 1.2e-05 25.1 0.0 3.3 3 0 0 3 3 3 2 PAS domain PAS_3 PF08447.12 CDK98166.1 - 2.9e-13 49.9 0.0 1.3e-11 44.7 0.0 2.5 2 0 0 2 2 2 1 PAS fold HisKA PF00512.25 CDK98166.1 - 2.3e-06 27.5 0.0 6e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain MipZ PF09140.11 CDK98167.1 - 2.8e-96 321.8 0.0 3.2e-96 321.6 0.0 1.0 1 0 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.6 CDK98167.1 - 1.3e-15 57.7 0.1 6.7e-13 48.9 0.1 2.2 1 1 0 1 1 1 1 AAA domain ParA PF10609.9 CDK98167.1 - 8.5e-11 41.8 0.1 1.7e-10 40.8 0.1 1.6 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CDK98167.1 - 5.8e-08 32.8 0.0 1e-07 32.0 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain CBP_BcsQ PF06564.12 CDK98167.1 - 5.3e-05 22.8 0.1 0.17 11.3 0.0 2.2 2 0 0 2 2 2 2 Cellulose biosynthesis protein BcsQ LpxK PF02606.14 CDK98167.1 - 0.0021 17.2 0.9 0.0033 16.6 0.9 1.4 1 1 0 1 1 1 1 Tetraacyldisaccharide-1-P 4'-kinase CLP1_P PF16575.5 CDK98167.1 - 0.006 16.4 0.0 0.019 14.8 0.0 1.8 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop ArsA_ATPase PF02374.15 CDK98167.1 - 0.01 15.0 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 0 Anion-transporting ATPase MeaB PF03308.16 CDK98167.1 - 0.02 13.9 0.1 0.027 13.5 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_26 PF13500.6 CDK98167.1 - 0.023 14.5 0.0 0.063 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain MobB PF03205.14 CDK98167.1 - 0.037 13.9 0.7 0.5 10.3 0.2 2.9 2 2 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B VirC1 PF07015.11 CDK98167.1 - 0.064 12.5 0.0 0.092 12.0 0.0 1.4 1 0 0 1 1 1 0 VirC1 protein TetR_N PF00440.23 CDK98168.1 - 6.1e-13 48.3 0.1 2.7e-12 46.3 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family 2-Hacid_dh_C PF02826.19 CDK98169.1 - 2.6e-54 183.3 0.0 5.1e-54 182.3 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDK98169.1 - 1e-22 80.2 0.0 1.2e-22 80.0 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CDK98169.1 - 3.1e-05 24.2 0.0 7.1e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 CDK98169.1 - 0.024 15.1 0.6 0.14 12.6 0.0 2.3 2 1 0 2 2 2 0 XdhC Rossmann domain Sigma70_r4 PF04545.16 CDK98170.1 - 2.8e-20 71.6 2.7 5.6e-19 67.4 2.3 2.5 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r2 PF04542.14 CDK98170.1 - 4.9e-16 58.3 0.0 1e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r1_2 PF00140.20 CDK98170.1 - 1.4e-06 28.2 0.1 3.2e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 Sigma-70 factor, region 1.2 Sigma70_r3 PF04539.16 CDK98170.1 - 0.00022 21.2 1.4 0.0024 17.9 0.1 2.3 2 0 0 2 2 2 1 Sigma-70 region 3 UCR_14kD PF02271.16 CDK98170.1 - 0.00032 20.6 0.2 0.0085 16.0 0.0 2.5 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Sigma70_r4_2 PF08281.12 CDK98170.1 - 0.00039 20.0 1.0 0.028 14.1 0.3 2.7 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_AsnC-type PF13404.6 CDK98170.1 - 0.00054 19.7 0.2 0.84 9.5 0.1 2.6 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain HTH_3 PF01381.22 CDK98170.1 - 0.0033 17.5 0.0 0.29 11.2 0.0 2.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_11 PF08279.12 CDK98170.1 - 0.0038 17.2 0.2 0.5 10.4 0.1 2.5 2 0 0 2 2 2 1 HTH domain MarR_2 PF12802.7 CDK98170.1 - 0.0044 16.9 0.3 4.5 7.3 0.1 2.8 2 0 0 2 2 2 2 MarR family HTH_23 PF13384.6 CDK98170.1 - 0.0062 16.3 0.1 3.1 7.7 0.1 2.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_31 PF13560.6 CDK98170.1 - 0.013 15.9 0.9 0.42 11.0 0.1 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_10 PF04967.12 CDK98170.1 - 0.025 14.3 0.0 3.9 7.4 0.0 2.8 2 0 0 2 2 2 0 HTH DNA binding domain GntR PF00392.21 CDK98170.1 - 0.031 13.9 0.5 1.5 8.6 0.1 2.8 2 1 1 3 3 3 0 Bacterial regulatory proteins, gntR family KORA PF16509.5 CDK98170.1 - 0.042 14.1 0.0 17 5.8 0.0 2.5 2 1 0 2 2 2 0 TrfB plasmid transcriptional repressor DUF3431 PF11913.8 CDK98170.1 - 0.062 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3431) HTH_6 PF01418.17 CDK98170.1 - 0.064 13.2 0.0 0.22 11.5 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family HTH_20 PF12840.7 CDK98170.1 - 0.081 13.0 0.3 1.2 9.2 0.0 2.5 3 0 0 3 3 2 0 Helix-turn-helix domain HTH_28 PF13518.6 CDK98170.1 - 0.083 13.0 0.3 4.9 7.4 0.1 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_50 PF18024.1 CDK98170.1 - 0.092 12.4 1.1 0.29 10.8 0.0 2.4 3 0 0 3 3 2 0 Helix-turn-helix domain TrmB PF01978.19 CDK98170.1 - 0.11 12.4 0.0 4.8 7.1 0.0 2.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB PgaD PF13994.6 CDK98170.1 - 0.12 12.5 0.3 5.7 7.0 0.1 2.3 2 0 0 2 2 2 0 PgaD-like protein Chorismate_bind PF00425.18 CDK98171.1 - 1.3e-94 316.6 0.0 2.1e-94 315.9 0.0 1.4 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 CDK98171.1 - 4.9e-29 101.4 0.0 8.7e-28 97.3 0.0 2.4 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region SurA_N_3 PF13624.6 CDK98172.1 - 3.1e-38 131.1 2.4 4.9e-38 130.5 0.2 2.5 3 0 0 3 3 3 1 SurA N-terminal domain Rotamase_2 PF13145.6 CDK98172.1 - 1.3e-36 126.0 14.8 5.5e-22 78.9 0.5 4.9 5 1 0 5 5 5 4 PPIC-type PPIASE domain SurA_N_2 PF13623.6 CDK98172.1 - 2.3e-20 72.9 0.3 2.2e-19 69.8 0.0 2.7 4 0 0 4 4 4 1 SurA N-terminal domain Rotamase PF00639.21 CDK98172.1 - 2.4e-12 47.6 0.8 2e-05 25.4 0.0 3.6 2 1 0 2 2 2 2 PPIC-type PPIASE domain Rotamase_3 PF13616.6 CDK98172.1 - 2.6e-09 37.6 0.1 0.0016 19.0 0.0 2.9 2 0 0 2 2 2 2 PPIC-type PPIASE domain Band_7 PF01145.25 CDK98172.1 - 0.037 14.1 0.0 2.2 8.2 0.0 3.0 2 1 1 3 3 3 0 SPFH domain / Band 7 family TIM PF00121.18 CDK98173.1 - 1.8e-83 279.6 0.0 2e-83 279.5 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase SecG PF03840.14 CDK98174.1 - 3.1e-17 62.4 10.6 3.8e-17 62.1 10.6 1.1 1 0 0 1 1 1 1 Preprotein translocase SecG subunit CTP_synth_N PF06418.14 CDK98175.1 - 2.9e-120 400.5 0.0 4.1e-120 400.0 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 CDK98175.1 - 2.8e-53 180.5 0.0 4.1e-53 180.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CDK98175.1 - 3.7e-08 33.4 0.0 5.4e-07 29.6 0.0 2.7 3 1 0 3 3 3 1 Peptidase C26 CbiA PF01656.23 CDK98175.1 - 0.051 13.6 0.0 0.087 12.9 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DAHP_synth_1 PF00793.20 CDK98176.1 - 4.5e-66 222.5 0.0 5.6e-66 222.2 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Enolase_C PF00113.22 CDK98177.1 - 1.1e-128 428.7 0.1 1.3e-128 428.4 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 CDK98177.1 - 6.9e-62 207.4 0.1 1.7e-61 206.2 0.1 1.7 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 CDK98177.1 - 1.8e-08 34.2 0.0 3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CDK98177.1 - 0.00019 20.7 0.4 0.00038 19.7 0.1 1.6 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus DivIC PF04977.15 CDK98179.1 - 1.4e-14 53.6 0.0 1.9e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Septum formation initiator MCPsignal PF00015.21 CDK98180.1 - 6.6e-30 104.2 29.2 6.6e-30 104.2 29.2 3.6 3 1 1 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain 4HB_MCP_1 PF12729.7 CDK98180.1 - 0.00014 21.5 0.5 0.00014 21.5 0.5 3.4 2 1 3 5 5 5 1 Four helix bundle sensory module for signal transduction HAMP PF00672.25 CDK98180.1 - 0.002 18.4 1.1 0.002 18.4 1.1 4.7 4 1 0 4 4 4 1 HAMP domain Seryl_tRNA_N PF02403.22 CDK98180.1 - 1.5 9.1 21.1 0.29 11.4 0.6 4.4 4 2 1 5 5 5 0 Seryl-tRNA synthetase N-terminal domain Sec34 PF04136.15 CDK98180.1 - 1.9 8.4 10.4 0.91 9.4 0.2 3.9 4 1 0 4 4 4 0 Sec34-like family DUF1664 PF07889.12 CDK98180.1 - 2.8 8.0 20.6 2.9 8.0 4.1 4.7 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) DUF389 PF04087.14 CDK98180.1 - 9.8 6.2 12.7 0.16 12.0 0.4 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF389) E1_dh PF00676.20 CDK98181.1 - 3.7e-99 331.5 0.1 4.3e-99 331.2 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 CDK98181.1 - 0.00017 21.4 0.6 0.0008 19.2 0.6 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 CDK98181.1 - 0.00058 19.2 0.0 0.00088 18.6 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 CDK98182.1 - 5.8e-49 166.2 0.1 9.3e-49 165.5 0.1 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDK98182.1 - 2.3e-42 143.8 0.0 5.3e-42 142.6 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain Biotin_lipoyl PF00364.22 CDK98182.1 - 6.5e-18 64.3 1.3 1.7e-17 63.0 1.3 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDK98182.1 - 0.0001 22.0 0.0 0.00021 21.0 0.0 1.4 1 0 0 1 1 1 1 Biotin-lipoyl like PFOR_II PF17147.4 CDK98182.1 - 0.0086 16.4 0.0 0.029 14.7 0.0 1.8 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II 2-oxoacid_dh PF00198.23 CDK98183.1 - 3.3e-85 285.2 0.0 5.1e-85 284.6 0.0 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CDK98183.1 - 2.8e-19 68.7 0.3 5.4e-19 67.8 0.3 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CDK98183.1 - 2.6e-15 56.4 0.4 7.4e-15 55.0 0.4 1.9 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CDK98183.1 - 1.3e-05 24.9 0.0 3.8e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like QRPTase_N PF02749.16 CDK98183.1 - 0.069 13.2 0.1 0.3 11.2 0.0 2.1 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain DUF5488 PF17590.2 CDK98183.1 - 0.12 12.2 0.3 21 4.9 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5488) DUF3614 PF12267.8 CDK98183.1 - 0.14 12.7 0.1 0.44 11.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3614) SARG PF15385.6 CDK98183.1 - 0.31 10.2 0.8 0.48 9.6 0.8 1.2 1 0 0 1 1 1 0 Specifically androgen-regulated gene protein Ribosomal_60s PF00428.19 CDK98183.1 - 0.62 10.7 31.1 0.31 11.7 7.8 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein Pyr_redox_2 PF07992.14 CDK98186.1 - 6.8e-62 209.4 6.0 6.8e-62 209.4 6.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDK98186.1 - 1.2e-35 122.0 0.8 2.5e-35 121.0 0.8 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDK98186.1 - 2.9e-25 88.6 8.8 1e-22 80.4 0.8 3.1 4 0 0 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDK98186.1 - 2e-15 56.9 5.1 1.5e-14 54.0 5.1 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDK98186.1 - 9.9e-10 38.3 0.5 9.9e-10 38.3 0.5 2.0 2 1 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 CDK98186.1 - 2.3e-09 36.9 7.1 1.4e-08 34.3 4.2 2.6 2 1 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CDK98186.1 - 3.4e-08 33.0 9.0 4.6e-07 29.3 1.1 4.0 4 1 0 4 4 4 1 FAD binding domain NAD_binding_8 PF13450.6 CDK98186.1 - 1.2e-06 28.6 3.1 0.0036 17.5 0.3 3.2 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDK98186.1 - 6.4e-06 26.0 15.4 0.013 15.1 0.2 4.1 4 0 0 4 4 4 2 FAD dependent oxidoreductase HI0933_like PF03486.14 CDK98186.1 - 9.4e-06 24.6 14.2 0.00026 19.8 1.0 3.7 3 1 1 4 4 4 3 HI0933-like protein FAD_binding_3 PF01494.19 CDK98186.1 - 9.7e-05 21.8 3.3 0.015 14.5 0.4 2.5 2 1 0 2 2 2 2 FAD binding domain 2-Hacid_dh_C PF02826.19 CDK98186.1 - 0.00012 21.5 0.3 0.0082 15.5 0.0 2.7 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CDK98186.1 - 0.012 15.5 1.1 0.012 15.5 1.1 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 CDK98186.1 - 0.03 13.5 0.1 0.03 13.5 0.1 2.2 3 0 0 3 3 3 0 Thi4 family AlaDh_PNT_C PF01262.21 CDK98186.1 - 0.035 13.4 19.3 0.087 12.1 0.2 3.6 3 1 1 4 4 4 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 CDK98186.1 - 0.13 12.7 5.6 0.25 11.8 0.4 2.7 3 0 0 3 3 2 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 CDK98186.1 - 0.16 10.8 2.9 0.07 12.0 0.3 1.7 2 0 0 2 2 2 0 Tryptophan halogenase Amino_oxidase PF01593.24 CDK98186.1 - 0.23 10.7 1.2 0.33 10.2 0.4 1.6 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 CDK98186.1 - 2 7.4 6.9 1.5 7.8 0.9 2.7 2 1 1 3 3 3 0 Lycopene cyclase protein Radical_SAM PF04055.21 CDK98187.1 - 7.7e-14 52.4 0.1 3.4e-13 50.3 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily LIAS_N PF16881.5 CDK98187.1 - 1.1e-07 32.2 0.1 1.8e-07 31.5 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Polyketide_cyc PF03364.20 CDK98188.1 - 8.3e-31 106.9 0.0 9.5e-31 106.7 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 CDK98188.1 - 5e-07 30.1 0.0 6.6e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Methyltransf_25 PF13649.6 CDK98189.1 - 7.3e-06 26.6 0.1 1.2e-05 25.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK98189.1 - 0.0013 19.3 0.0 0.002 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK98189.1 - 0.015 16.0 0.0 0.033 14.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 CDK98189.1 - 0.024 14.3 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_31 PF13847.6 CDK98189.1 - 0.054 13.3 0.2 0.099 12.4 0.2 1.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CDK98189.1 - 0.081 12.8 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PmbA_TldD PF01523.16 CDK98190.1 - 5.1e-62 210.2 0.5 9.1e-62 209.4 0.1 1.6 2 0 0 2 2 2 1 Putative modulator of DNA gyrase DUF3422 PF11902.8 CDK98191.1 - 2.5e-166 554.0 6.0 2.8e-166 553.8 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3422) ABC_tran_CTD PF16326.5 CDK98191.1 - 0.23 11.8 3.5 0.15 12.3 0.5 2.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain MCPsignal PF00015.21 CDK98192.1 - 2.3e-28 99.1 29.2 2.3e-28 99.1 29.2 3.8 2 1 2 4 4 4 1 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK98192.1 - 8.6e-09 35.6 6.4 2.1e-08 34.4 0.1 4.5 4 0 0 4 4 4 1 HAMP domain DUF1843 PF08898.10 CDK98192.1 - 2.9 8.5 10.0 1.3 9.5 2.7 4.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) DUF1664 PF07889.12 CDK98192.1 - 4.7 7.3 20.0 1 9.4 1.5 4.7 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) EAL PF00563.20 CDK98193.1 - 2.2e-50 171.4 0.1 2.8e-50 171.1 0.1 1.0 1 0 0 1 1 1 1 EAL domain GvpK PF05121.12 CDK98194.1 - 0.068 13.2 1.8 0.16 12.0 1.8 1.6 1 0 0 1 1 1 0 Gas vesicle protein K Mating_N PF12731.7 CDK98194.1 - 0.069 13.2 2.6 0.39 10.8 0.2 2.6 2 1 1 3 3 3 0 Mating-type protein beta 1 FAA_hydro_N_2 PF18288.1 CDK98194.1 - 1.2 9.6 7.1 2.5 8.6 0.6 2.5 2 1 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 CheB_methylest PF01339.17 CDK98195.1 - 2.9e-60 202.9 0.8 5.8e-60 201.9 0.2 1.8 2 1 0 2 2 2 1 CheB methylesterase Response_reg PF00072.24 CDK98195.1 - 2.3e-24 85.7 0.1 1.2e-23 83.4 0.1 2.1 2 0 0 2 2 2 1 Response regulator receiver domain CheD PF03975.13 CDK98196.1 - 3.1e-29 101.3 0.0 5.3e-29 100.5 0.0 1.4 1 0 0 1 1 1 1 CheD chemotactic sensory transduction CheR PF01739.18 CDK98197.1 - 7.4e-62 208.3 0.0 9.2e-62 208.0 0.0 1.1 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.15 CDK98197.1 - 1.1e-15 57.1 0.0 2.7e-15 55.8 0.0 1.7 1 0 0 1 1 1 1 CheR methyltransferase, all-alpha domain Methyltransf_25 PF13649.6 CDK98197.1 - 0.026 15.2 0.2 0.46 11.2 0.0 2.7 1 1 1 2 2 2 0 Methyltransferase domain MCPsignal PF00015.21 CDK98198.1 - 7.7e-52 175.6 18.8 7.7e-52 175.6 18.8 5.0 4 1 0 5 5 5 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK98198.1 - 1.3e-14 54.3 19.0 1.3e-10 41.5 0.3 6.7 7 0 0 7 7 7 3 HAMP domain 4HB_MCP_1 PF12729.7 CDK98198.1 - 4.4e-06 26.4 0.1 4.4e-06 26.4 0.1 5.8 5 3 1 7 7 7 1 Four helix bundle sensory module for signal transduction LrgA PF03788.14 CDK98198.1 - 0.057 13.4 1.8 0.19 11.7 0.5 2.2 2 0 0 2 2 2 0 LrgA family Exo70 PF03081.15 CDK98198.1 - 0.38 9.8 8.7 0.92 8.5 0.1 3.4 4 0 0 4 4 4 0 Exo70 exocyst complex subunit Tweety PF04906.13 CDK98198.1 - 3.7 6.1 9.9 0.67 8.6 0.2 3.5 3 1 0 3 3 3 0 Tweety CheW PF01584.19 CDK98199.1 - 1.5e-36 125.1 0.3 1.8e-36 124.8 0.3 1.0 1 0 0 1 1 1 1 CheW-like domain CheW PF01584.19 CDK98200.1 - 2.6e-25 88.7 1.9 5.1e-25 87.7 1.9 1.5 1 0 0 1 1 1 1 CheW-like domain H-kinase_dim PF02895.14 CDK98200.1 - 4.1e-19 68.7 0.4 1.2e-18 67.3 0.4 1.9 1 0 0 1 1 1 1 Signal transducing histidine kinase, homodimeric domain HATPase_c PF02518.26 CDK98200.1 - 1.8e-17 63.9 0.1 4.1e-17 62.7 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Hpt PF01627.23 CDK98200.1 - 4.8e-14 52.4 1.0 4.8e-14 52.4 1.0 2.5 3 0 0 3 3 3 1 Hpt domain HATPase_c_3 PF13589.6 CDK98200.1 - 0.04 13.7 0.0 0.067 13.0 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SF3b1 PF08920.10 CDK98200.1 - 0.07 13.6 0.1 1.5 9.4 0.0 2.4 2 0 0 2 2 2 0 Splicing factor 3B subunit 1 Response_reg PF00072.24 CDK98201.1 - 8.3e-29 100.0 0.0 9.2e-29 99.9 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain LpxC PF03331.13 CDK98201.1 - 0.02 14.4 0.1 0.027 14.0 0.1 1.1 1 0 0 1 1 1 0 UDP-3-O-acyl N-acetylglycosamine deacetylase STAS_2 PF13466.6 CDK98202.1 - 2.2e-10 40.7 6.5 2.6e-10 40.5 6.5 1.1 1 0 0 1 1 1 1 STAS domain STAS PF01740.21 CDK98202.1 - 0.0026 17.4 0.0 0.0026 17.4 0.0 1.1 1 0 0 1 1 1 1 STAS domain PPK2 PF03976.14 CDK98204.1 - 1.3e-104 348.7 1.1 1.6e-104 348.4 1.1 1.1 1 0 0 1 1 1 1 Polyphosphate kinase 2 (PPK2) MeaB PF03308.16 CDK98204.1 - 0.14 11.1 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SpoU_methylase PF00588.19 CDK98205.1 - 2.9e-35 121.5 0.0 3.8e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 CDK98205.1 - 2.3e-07 31.0 0.0 3.6e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding Methyltrn_RNA_4 PF09936.9 CDK98205.1 - 0.1 12.4 0.0 0.29 11.0 0.0 1.8 2 0 0 2 2 2 0 SAM-dependent RNA methyltransferase PseudoU_synth_2 PF00849.22 CDK98206.1 - 1.2e-16 61.2 0.0 1e-14 55.0 0.0 2.1 1 1 0 1 1 1 1 RNA pseudouridylate synthase Flavodoxin_2 PF02525.17 CDK98207.1 - 2.6e-49 167.6 0.0 2.9e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 CDK98207.1 - 2.9e-10 40.1 0.0 3.6e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Bacillus_PapR PF05968.11 CDK98207.1 - 0.94 9.4 4.4 14 5.7 0.2 2.4 2 0 0 2 2 2 0 Bacillus PapR protein LysR_substrate PF03466.20 CDK98208.1 - 2.1e-20 73.0 1.2 2.1e-20 73.0 1.2 1.6 2 0 0 2 2 2 1 LysR substrate binding domain HTH_1 PF00126.27 CDK98208.1 - 1.1e-18 66.9 0.2 2.4e-18 65.8 0.2 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family DDE_3 PF13358.6 CDK98209.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK98209.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDK98210.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK98210.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK98210.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK98210.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK98210.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK98210.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain LysR_substrate PF03466.20 CDK98211.1 - 3.2e-15 56.1 0.8 3.4e-15 56.0 0.8 1.0 1 0 0 1 1 1 1 LysR substrate binding domain UvrA_DNA-bind PF17755.1 CDK98213.1 - 5.6e-41 139.3 0.0 3.4e-39 133.6 0.0 2.7 3 0 0 3 3 2 1 UvrA DNA-binding domain UvrA_inter PF17760.1 CDK98213.1 - 6.8e-39 132.3 0.0 1.3e-38 131.4 0.0 1.5 1 0 0 1 1 1 1 UvrA interaction domain ABC_tran PF00005.27 CDK98213.1 - 4.6e-21 75.8 0.0 3.7e-05 24.3 0.0 4.3 4 0 0 4 4 4 4 ABC transporter SMC_N PF02463.19 CDK98213.1 - 3e-09 36.6 0.0 0.05 13.0 0.0 4.1 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDK98213.1 - 4.1e-07 29.6 0.0 0.032 14.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CDK98213.1 - 1.2e-06 29.0 0.0 0.045 14.1 0.0 3.3 4 0 0 4 4 4 2 AAA ATPase domain AAA_21 PF13304.6 CDK98213.1 - 0.00014 21.8 4.7 0.0072 16.2 0.0 3.9 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CDK98213.1 - 0.00024 20.7 0.0 0.64 9.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CDK98213.1 - 0.00072 19.8 0.3 3.7 7.8 0.0 3.4 3 0 0 3 3 3 2 AAA domain DnaJ_CXXCXGXG PF00684.19 CDK98213.1 - 0.0014 19.0 4.0 0.033 14.6 0.4 3.3 3 0 0 3 3 3 1 DnaJ central domain RsgA_GTPase PF03193.16 CDK98213.1 - 0.0017 18.3 0.1 1.2 9.1 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase BCA_ABC_TP_C PF12399.8 CDK98213.1 - 0.0021 17.9 1.2 0.029 14.3 0.1 2.5 2 0 0 2 2 2 1 Branched-chain amino acid ATP-binding cassette transporter AAA_23 PF13476.6 CDK98213.1 - 0.0034 17.9 0.2 0.31 11.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 CDK98213.1 - 0.0046 16.3 0.0 3.5 6.9 0.0 2.5 2 0 0 2 2 2 2 KaiC APS_kinase PF01583.20 CDK98213.1 - 0.005 16.7 0.2 1.3 8.9 0.0 3.0 3 0 0 3 3 3 1 Adenylylsulphate kinase AAA_18 PF13238.6 CDK98213.1 - 0.0078 16.8 0.0 5.5 7.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 CDK98213.1 - 0.026 13.8 0.0 3.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 CDK98213.1 - 0.038 14.2 0.1 3.1 8.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CDK98213.1 - 0.041 13.9 0.0 5.6 7.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 CDK98213.1 - 0.052 13.5 0.0 12 5.7 0.0 2.5 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 CDK98213.1 - 0.095 12.3 0.5 10 5.7 0.2 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Anti-TRAP PF15777.5 CDK98213.1 - 1.9 8.5 4.8 7.7 6.6 0.2 3.1 3 0 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein SSB PF00436.25 CDK98216.1 - 1.7e-37 127.6 0.5 2.1e-37 127.3 0.5 1.0 1 0 0 1 1 1 1 Single-strand binding protein family tRNA_anti-codon PF01336.25 CDK98216.1 - 0.07 13.1 0.1 0.14 12.2 0.1 1.7 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain GRP PF07172.11 CDK98216.1 - 0.36 11.5 14.8 0.56 10.9 14.8 1.3 1 0 0 1 1 1 0 Glycine rich protein family DNA_topoisoIV PF00521.20 CDK98217.1 - 1.3e-150 502.0 0.0 1.7e-150 501.6 0.0 1.1 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 CDK98217.1 - 6.1e-68 224.1 17.8 4.7e-14 51.6 0.2 7.1 7 0 0 7 7 7 6 DNA gyrase C-terminal domain, beta-propeller CAP18_C PF12153.8 CDK98217.1 - 0.28 11.1 3.6 0.56 10.1 3.6 1.5 1 0 0 1 1 1 0 LPS binding domain of CAP18 (C terminal) CTP_transf_like PF01467.26 CDK98218.1 - 1.3e-15 57.9 0.0 1.5e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like Citrate_ly_lig PF08218.11 CDK98218.1 - 0.082 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Citrate lyase ligase C-terminal domain Pro_isomerase PF00160.21 CDK98219.1 - 3.3e-45 154.2 0.0 3.8e-45 154.0 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pro_isomerase PF00160.21 CDK98220.1 - 1.4e-44 152.1 0.0 1.7e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HNH_5 PF14279.6 CDK98223.1 - 1.4e-10 40.8 0.1 1.2e-09 37.9 0.1 2.0 1 1 1 2 2 2 1 HNH endonuclease HNH PF01844.23 CDK98223.1 - 1.9e-09 37.5 0.0 5.1e-09 36.2 0.0 1.7 1 1 0 1 1 1 1 HNH endonuclease HNH_4 PF13395.6 CDK98223.1 - 2.1e-07 30.8 0.0 7.5e-07 29.0 0.0 1.8 1 1 0 1 1 1 1 HNH endonuclease DZR PF12773.7 CDK98223.1 - 0.04 13.9 5.4 0.075 13.1 5.4 1.4 1 1 0 1 1 1 0 Double zinc ribbon Endonuclease_7 PF02945.15 CDK98223.1 - 0.21 11.5 3.4 1.3 8.9 3.4 2.0 1 1 0 1 1 1 0 Recombination endonuclease VII EAL PF00563.20 CDK98224.1 - 3.7e-71 239.4 0.0 7.3e-71 238.4 0.0 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK98224.1 - 3.3e-45 153.7 0.0 5.5e-45 153.0 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDK98224.1 - 8e-37 125.7 0.0 2.2e-14 53.6 0.0 3.4 3 0 0 3 3 3 3 PAS domain PAS_4 PF08448.10 CDK98224.1 - 8.7e-26 90.3 7.8 1e-12 48.3 0.3 4.0 4 0 0 4 4 4 3 PAS fold PAS PF00989.25 CDK98224.1 - 2.3e-25 88.8 0.0 2e-09 37.4 0.0 3.6 3 0 0 3 3 3 3 PAS fold PAS_3 PF08447.12 CDK98224.1 - 9.4e-22 77.1 0.5 3.7e-07 30.3 0.0 3.5 3 0 0 3 3 3 3 PAS fold PAS_8 PF13188.7 CDK98224.1 - 2.6e-19 68.8 2.5 3.1e-06 27.1 0.0 4.7 5 0 0 5 5 5 3 PAS domain PAS_10 PF13596.6 CDK98224.1 - 0.0053 17.3 0.0 0.039 14.5 0.0 2.3 2 0 0 2 2 2 1 PAS domain GGDEF_2 PF17853.1 CDK98224.1 - 0.046 14.0 2.5 1.4 9.2 0.0 3.7 4 1 0 4 4 4 0 GGDEF-like domain SAM_adeno_trans PF01887.16 CDK98225.1 - 3.5e-69 232.8 0.0 4e-69 232.6 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-l-methionine hydroxide adenosyltransferase Lactamase_B_2 PF12706.7 CDK98226.1 - 1.6e-27 96.4 0.4 2.1e-27 96.0 0.4 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDK98226.1 - 2.2e-05 24.5 4.2 0.00011 22.3 4.2 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily MotB_plug PF13677.6 CDK98227.1 - 1.1e-14 53.7 0.6 1.8e-14 53.0 0.6 1.3 1 0 0 1 1 1 1 Membrane MotB of proton-channel complex MotA/MotB OmpA PF00691.20 CDK98227.1 - 1.7e-13 50.8 0.0 3.5e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 OmpA family ExbD PF02472.16 CDK98227.1 - 0.013 15.7 0.9 0.019 15.2 0.9 1.5 1 1 0 1 1 1 0 Biopolymer transport protein ExbD/TolR MotA_ExbB PF01618.16 CDK98228.1 - 3.2e-20 72.2 0.4 3.2e-20 72.2 0.4 2.1 2 0 0 2 2 2 1 MotA/TolQ/ExbB proton channel family DUF4149 PF13664.6 CDK98228.1 - 0.2 12.0 4.9 0.28 11.5 0.9 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) DUF423 PF04241.15 CDK98228.1 - 2.7 8.2 5.5 0.9 9.8 1.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF423) DUF2207 PF09972.9 CDK98228.1 - 5.5 5.6 5.9 2.2 6.9 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Bax1-I PF01027.20 CDK98228.1 - 8.6 6.1 12.4 19 5.0 7.4 2.2 2 0 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 EAL PF00563.20 CDK98229.1 - 7.9e-79 264.5 0.0 1.2e-78 263.9 0.0 1.3 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK98229.1 - 1.9e-40 138.3 1.5 2.6e-40 137.8 0.0 1.9 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDK98229.1 - 7.3e-20 71.2 0.0 1.8e-19 69.9 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CDK98229.1 - 1.1e-15 57.6 0.1 2.7e-15 56.4 0.1 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDK98229.1 - 1.4e-14 54.3 1.4 1.4e-14 54.3 1.4 2.1 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 CDK98229.1 - 6.9e-09 35.9 0.2 1.6e-08 34.7 0.2 1.7 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK98229.1 - 4.6e-05 23.3 0.3 0.00016 21.6 0.0 2.1 2 0 0 2 2 2 1 PAS domain PAS_7 PF12860.7 CDK98229.1 - 0.013 15.6 0.4 0.052 13.7 0.3 2.1 1 1 0 1 1 1 0 PAS fold Trypsin PF00089.26 CDK98230.1 - 8.5e-09 35.5 0.5 0.00095 19.0 0.0 2.1 2 0 0 2 2 2 2 Trypsin Trypsin_2 PF13365.6 CDK98230.1 - 0.00016 22.6 0.0 0.00027 21.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain ATP-grasp_5 PF13549.6 CDK98231.1 - 2.9e-88 295.0 0.2 4.3e-88 294.5 0.2 1.3 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 CDK98231.1 - 8.4e-56 187.6 0.4 2.2e-55 186.2 0.4 1.8 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CDK98231.1 - 1.2e-17 64.5 0.2 7.2e-17 62.0 0.0 2.5 2 0 0 2 2 1 1 CoA binding domain Acetyltransf_1 PF00583.25 CDK98231.1 - 1.4e-09 38.2 0.0 2.7e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CDK98231.1 - 2e-07 31.8 0.0 4.6e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CoA_binding PF02629.19 CDK98231.1 - 1.7e-05 25.4 0.0 4.8e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 CoA binding domain Acetyltransf_10 PF13673.7 CDK98231.1 - 2.4e-05 24.3 0.0 4.8e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDK98231.1 - 0.0009 19.2 0.1 0.003 17.5 0.0 1.9 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_8 PF13523.6 CDK98231.1 - 0.001 18.8 0.0 0.0045 16.7 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDK98231.1 - 0.019 15.4 0.0 0.041 14.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ATP-grasp_2 PF08442.10 CDK98231.1 - 0.048 13.2 0.0 0.085 12.4 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain Acetyltransf_4 PF13420.7 CDK98231.1 - 0.069 13.3 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDK98231.1 - 0.19 11.9 0.0 0.51 10.5 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase SLAC1 PF03595.17 CDK98232.1 - 1.2e-54 185.8 45.5 1.4e-54 185.6 45.5 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel PTA_PTB PF01515.19 CDK98233.1 - 3.6e-49 167.8 2.7 3.2e-44 151.6 5.0 2.2 1 1 1 2 2 2 2 Phosphate acetyl/butaryl transferase MaoC_dehydratas PF01575.19 CDK98233.1 - 2.1e-12 46.7 0.0 4.2e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CDK98233.1 - 8e-06 26.0 0.0 1.5e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase Acetate_kinase PF00871.17 CDK98234.1 - 1.4e-108 363.1 0.0 1.6e-108 362.9 0.0 1.0 1 0 0 1 1 1 1 Acetokinase family Glucokinase PF02685.16 CDK98234.1 - 0.018 14.1 0.0 0.03 13.3 0.0 1.3 1 0 0 1 1 1 0 Glucokinase cNMP_binding PF00027.29 CDK98236.1 - 2.1e-20 72.6 0.0 3.2e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CinA PF02464.17 CDK98238.1 - 4.7e-52 175.7 3.4 5.5e-52 175.4 3.4 1.0 1 0 0 1 1 1 1 Competence-damaged protein PgpA PF04608.13 CDK98239.1 - 1.5e-47 161.2 7.6 1.8e-47 161.0 7.6 1.0 1 0 0 1 1 1 1 Phosphatidylglycerophosphatase A HATPase_c PF02518.26 CDK98240.1 - 5.5e-26 91.3 0.0 1.6e-25 89.7 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98240.1 - 5.7e-18 64.7 0.0 5.7e-18 64.7 0.0 3.6 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CDK98240.1 - 0.0029 17.4 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HPTransfase PF10090.9 CDK98240.1 - 0.014 15.2 0.0 0.044 13.6 0.0 1.8 1 0 0 1 1 1 0 Histidine phosphotransferase C-terminal domain PAS_4 PF08448.10 CDK98240.1 - 0.082 13.2 0.1 0.41 10.9 0.0 2.3 2 0 0 2 2 2 0 PAS fold DUF948 PF06103.11 CDK98240.1 - 0.29 11.4 1.6 0.4 11.0 0.4 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Oxidored_molyb PF00174.19 CDK98241.1 - 3.1e-39 134.4 0.0 4.2e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain SmpB PF01668.18 CDK98242.1 - 3.7e-55 185.8 0.1 4.2e-55 185.6 0.1 1.0 1 0 0 1 1 1 1 SmpB protein DHDPS PF00701.22 CDK98243.1 - 1.5e-96 322.5 0.0 1.7e-96 322.3 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PA PF02225.22 CDK98243.1 - 0.013 15.5 0.6 0.079 13.0 0.1 2.3 2 0 0 2 2 2 0 PA domain SLT PF01464.20 CDK98244.1 - 1.9e-26 92.0 0.0 5.9e-26 90.4 0.0 1.7 2 0 0 2 2 2 1 Transglycosylase SLT domain TPR_8 PF13181.6 CDK98244.1 - 0.079 13.2 0.2 4.6 7.7 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDK98244.1 - 0.83 10.4 6.3 28 5.6 0.0 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ILVD_EDD PF00920.21 CDK98245.1 - 1.2e-215 717.0 8.9 1.4e-215 716.9 8.9 1.0 1 0 0 1 1 1 1 Dehydratase family Response_reg PF00072.24 CDK98246.1 - 2.2e-21 76.1 0.1 4.6e-21 75.1 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Hemerythrin PF01814.23 CDK98246.1 - 3.7e-14 53.4 0.8 6.3e-14 52.7 0.8 1.4 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain BRCT_3 PF18428.1 CDK98246.1 - 0.00012 22.1 0.1 0.00026 21.0 0.1 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain FleQ PF06490.11 CDK98246.1 - 0.0064 16.9 0.1 0.013 15.9 0.1 1.5 1 0 0 1 1 1 1 Flagellar regulatory protein FleQ Haem_oxygenas_2 PF14518.6 CDK98247.1 - 2.2e-06 27.6 0.0 4.1e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Iron-containing redox enzyme DUF423 PF04241.15 CDK98247.1 - 0.013 15.7 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF423) NAD_binding_1 PF00175.21 CDK98248.1 - 7.3e-11 42.7 0.0 1.1e-10 42.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CDK98248.1 - 5.5e-08 33.1 0.0 1.1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Exo_endo_phos PF03372.23 CDK98249.1 - 1.1e-25 90.5 1.0 1.4e-25 90.2 1.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Fe-S_biosyn PF01521.20 CDK98251.1 - 2.5e-22 79.2 0.0 2.8e-22 79.0 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis HD_assoc PF13286.6 CDK98252.1 - 3e-29 101.4 0.0 7.8e-29 100.1 0.0 1.8 1 0 0 1 1 1 1 Phosphohydrolase-associated domain HD PF01966.22 CDK98252.1 - 1e-12 48.3 0.1 1.8e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 CDK98252.1 - 0.00044 19.8 0.0 0.00098 18.6 0.0 1.5 2 0 0 2 2 2 1 HDOD domain DALR_1 PF05746.15 CDK98253.1 - 4.9e-30 104.1 0.0 2.6e-29 101.8 0.0 2.1 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 CDK98253.1 - 1.5e-22 79.9 0.1 4.4e-22 78.5 0.0 1.8 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1d PF00750.19 CDK98253.1 - 2.5e-18 66.1 0.0 1.6e-11 43.8 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (R) tRNA-synt_1f PF01921.18 CDK98253.1 - 1.3e-07 30.9 0.0 0.00013 21.0 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (K) tRNA-synt_1e PF01406.19 CDK98253.1 - 1.8e-06 27.5 0.0 0.025 13.9 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CDK98253.1 - 0.00025 19.9 0.1 0.031 13.0 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CDK98253.1 - 0.00029 19.2 0.2 0.018 13.3 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) SPOR PF05036.13 CDK98254.1 - 3.5e-11 43.3 0.7 5.2e-11 42.8 0.1 1.6 2 0 0 2 2 2 1 Sporulation related domain Glyco_hydro_3 PF00933.21 CDK98255.1 - 3.4e-50 171.2 0.0 4.5e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Peptidase_M50 PF02163.22 CDK98256.1 - 4.8e-06 26.0 2.0 4.8e-06 26.0 2.0 3.4 3 1 1 4 4 4 3 Peptidase family M50 MRAP PF15183.6 CDK98256.1 - 0.019 14.9 0.1 0.033 14.1 0.1 1.4 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family SMC_ScpA PF02616.14 CDK98257.1 - 1.6e-13 51.1 0.3 9.6e-13 48.6 0.3 1.9 1 1 0 1 1 1 1 Segregation and condensation protein ScpA Rad21_Rec8 PF04824.16 CDK98257.1 - 0.017 14.4 0.0 0.035 13.4 0.0 1.5 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein SMC_ScpB PF04079.16 CDK98258.1 - 5.7e-46 156.1 0.0 7.1e-46 155.7 0.0 1.1 1 0 0 1 1 1 1 Segregation and condensation complex subunit ScpB MarR_2 PF12802.7 CDK98258.1 - 0.009 15.9 2.0 15 5.6 0.0 4.1 3 1 1 4 4 4 2 MarR family MttA_Hcf106 PF02416.16 CDK98259.1 - 1.5e-13 49.9 0.2 1.8e-13 49.6 0.2 1.2 1 0 0 1 1 1 1 mttA/Hcf106 family Ni_hydr_CYTB PF01292.20 CDK98259.1 - 0.029 13.9 0.1 0.035 13.7 0.1 1.2 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 DUF2206 PF09971.9 CDK98259.1 - 0.26 10.0 0.0 0.26 10.0 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) MttA_Hcf106 PF02416.16 CDK98260.1 - 3.1e-06 26.4 0.1 4.1e-06 26.0 0.1 1.3 1 1 0 1 1 1 1 mttA/Hcf106 family TatC PF00902.18 CDK98261.1 - 5.7e-68 228.8 16.1 5.7e-68 228.8 16.1 1.3 2 0 0 2 2 2 1 Sec-independent protein translocase protein (TatC) tRNA-synt_2b PF00587.25 CDK98262.1 - 3.9e-34 118.2 0.0 7.1e-34 117.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CDK98262.1 - 1.5e-30 105.6 0.2 2.5e-30 104.9 0.2 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF4201 PF13870.6 CDK98262.1 - 0.0045 16.7 0.0 0.0078 16.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) TMF_TATA_bd PF12325.8 CDK98262.1 - 0.039 14.2 1.5 0.13 12.5 1.5 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 CDK98262.1 - 1.9 8.3 4.2 5.5 6.8 0.1 2.3 1 1 1 2 2 2 0 Septum formation initiator SurE PF01975.17 CDK98263.1 - 5.3e-60 202.5 0.0 6.3e-60 202.3 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE PCMT PF01135.19 CDK98264.1 - 1.4e-60 204.7 0.0 1.6e-60 204.4 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 CDK98264.1 - 5.3e-06 27.1 0.0 9.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 CDK98264.1 - 5.3e-06 25.7 0.0 8.4e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.6 CDK98264.1 - 9e-06 25.6 0.0 1.4e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK98264.1 - 3.5e-05 24.4 0.0 6.2e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 CDK98264.1 - 3.6e-05 23.6 0.0 5e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_18 PF12847.7 CDK98264.1 - 0.0028 17.6 0.0 0.004 17.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDK98264.1 - 0.0077 15.8 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CDK98264.1 - 0.012 15.1 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase NodS PF05401.11 CDK98264.1 - 0.012 15.2 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) DUF938 PF06080.12 CDK98264.1 - 0.016 15.0 0.0 0.023 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_32 PF13679.6 CDK98264.1 - 0.018 15.0 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltr_RsmB-F PF01189.17 CDK98264.1 - 0.02 14.6 0.0 0.078 12.6 0.0 1.7 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F Enolase_like_N PF18374.1 CDK98264.1 - 0.06 12.7 0.0 0.15 11.4 0.0 1.7 1 0 0 1 1 1 0 Enolase N-terminal domain-like SAM_MT PF04445.13 CDK98264.1 - 0.065 12.6 0.0 0.087 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase Peptidase_M23 PF01551.22 CDK98265.1 - 2.8e-28 98.0 0.3 7.2e-28 96.6 0.3 1.8 1 0 0 1 1 1 1 Peptidase family M23 LysM PF01476.20 CDK98265.1 - 2.6e-25 88.2 0.0 4.5e-12 45.8 0.0 3.0 3 0 0 3 3 3 2 LysM domain HTH_38 PF13936.6 CDK98265.1 - 0.024 14.4 0.0 5.1 6.9 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain Biotin_lipoyl_2 PF13533.6 CDK98265.1 - 0.072 12.9 0.0 0.65 9.9 0.0 2.4 2 0 0 2 2 2 0 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK98265.1 - 0.091 12.6 0.1 0.34 10.8 0.0 2.0 2 0 0 2 2 2 0 Biotin-requiring enzyme RnfC_N PF13375.6 CDK98265.1 - 0.13 12.2 0.3 0.43 10.6 0.0 1.9 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain DUF815 PF05673.13 CDK98266.1 - 5.1e-104 346.9 0.0 5.8e-104 346.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 CDK98266.1 - 1.3e-09 38.6 0.3 2.3e-07 31.4 0.0 2.8 1 1 1 2 2 2 1 AAA ATPase domain AAA PF00004.29 CDK98266.1 - 0.00087 19.7 0.0 0.0025 18.3 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CDK98266.1 - 0.028 14.4 0.0 0.084 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CDK98266.1 - 0.036 13.8 0.0 0.076 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 CDK98266.1 - 0.036 13.8 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 CDK98266.1 - 0.12 11.9 0.0 1.1 8.7 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_PrkA PF08298.11 CDK98266.1 - 0.12 11.3 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 PrkA AAA domain YajC PF02699.15 CDK98267.1 - 4.8e-30 103.3 1.7 4.8e-30 103.3 1.7 1.3 1 1 0 1 1 1 1 Preprotein translocase subunit Orf78 PF06024.12 CDK98267.1 - 0.023 15.0 0.1 0.039 14.3 0.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) SecD_SecF PF02355.16 CDK98268.1 - 2.7e-16 59.5 11.4 4.6e-16 58.8 11.4 1.3 1 0 0 1 1 1 1 Protein export membrane protein Sec_GG PF07549.14 CDK98268.1 - 5.1e-05 22.6 0.1 0.00013 21.3 0.1 1.8 1 0 0 1 1 1 1 SecD/SecF GG Motif MMPL PF03176.15 CDK98268.1 - 0.00011 21.2 20.7 0.0002 20.4 20.7 1.3 1 0 0 1 1 1 1 MMPL family SecD-TM1 PF13721.6 CDK98268.1 - 0.067 13.7 0.3 0.067 13.7 0.3 3.1 3 1 1 4 4 4 0 SecD export protein N-terminal TM region ACR_tran PF00873.19 CDK98268.1 - 0.2 9.3 16.0 0.28 8.8 16.0 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family MaAIMP_sms PF16951.5 CDK98268.1 - 2.1 8.2 5.3 3.4 7.5 2.3 2.6 2 0 0 2 2 2 0 Putative methionine and alanine importer, small subunit SecD_SecF PF02355.16 CDK98269.1 - 5.2e-66 221.6 4.9 5.2e-66 221.6 4.9 1.3 2 0 0 2 2 2 1 Protein export membrane protein Sec_GG PF07549.14 CDK98269.1 - 3.6e-09 35.8 0.2 8.9e-09 34.6 0.2 1.7 1 0 0 1 1 1 1 SecD/SecF GG Motif ACR_tran PF00873.19 CDK98269.1 - 0.0001 20.1 0.4 0.00012 20.0 0.4 1.2 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family Bax1-I PF01027.20 CDK98269.1 - 7.4 6.3 23.8 11 5.8 17.3 2.5 2 1 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 DUF498 PF04430.14 CDK98270.1 - 6.6e-33 113.0 0.0 7.4e-33 112.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Mito_fiss_Elm1 PF06258.11 CDK98270.1 - 0.12 11.5 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial fission ELM1 NTP_transf_3 PF12804.7 CDK98271.1 - 5.5e-29 101.6 1.7 6.9e-29 101.3 1.7 1.0 1 0 0 1 1 1 1 MobA-like NTP transferase domain NiFe-hyd_HybE PF11939.8 CDK98272.1 - 1.9e-36 125.3 0.0 2.2e-36 125.1 0.0 1.0 1 0 0 1 1 1 1 [NiFe]-hydrogenase assembly, chaperone, HybE FBPase PF00316.20 CDK98273.1 - 9.2e-61 204.6 0.0 1.2e-60 204.3 0.0 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain CorA PF01544.18 CDK98274.1 - 3.1e-69 233.5 0.0 3.6e-69 233.3 0.0 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Na_Ca_ex PF01699.24 CDK98275.1 - 1.1e-50 171.5 34.1 4.2e-26 91.7 14.3 2.0 2 0 0 2 2 2 2 Sodium/calcium exchanger protein BatA PF07584.11 CDK98275.1 - 1.7 9.0 4.7 0.37 11.2 0.5 2.2 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal NnrS PF05940.12 CDK98276.1 - 1.2e-110 370.4 70.6 1.3e-110 370.2 70.6 1.0 1 0 0 1 1 1 1 NnrS protein DUF3938 PF13074.6 CDK98276.1 - 0.028 14.7 1.5 0.5 10.7 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3938) PEGA PF08308.11 CDK98277.1 - 0.0039 17.1 0.0 0.0061 16.4 0.0 1.3 1 0 0 1 1 1 1 PEGA domain ETF PF01012.21 CDK98278.1 - 4e-45 153.9 0.1 4e-45 153.9 0.1 1.4 2 0 0 2 2 2 1 Electron transfer flavoprotein domain LDB19 PF13002.7 CDK98278.1 - 0.09 12.5 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Arrestin_N terminal like ETF PF01012.21 CDK98279.1 - 5e-39 134.1 0.0 1e-38 133.0 0.0 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 CDK98279.1 - 1.8e-34 117.6 0.9 4.3e-34 116.4 0.9 1.7 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain FAD_binding_3 PF01494.19 CDK98280.1 - 1e-09 38.1 0.5 4.5e-09 36.0 0.1 2.1 3 1 0 3 3 3 1 FAD binding domain DAO PF01266.24 CDK98280.1 - 1.1e-09 38.4 0.1 0.00014 21.6 0.1 2.3 2 1 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 CDK98280.1 - 4.5e-07 28.9 1.8 0.00021 20.2 0.3 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 CDK98280.1 - 7.1e-07 28.8 3.1 0.0014 17.9 0.2 2.8 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDK98280.1 - 1.3e-06 28.0 0.1 1.8e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDK98280.1 - 2.1e-06 27.1 1.0 0.00049 19.3 0.5 2.3 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.22 CDK98280.1 - 2.8e-06 26.7 3.0 3.2e-05 23.2 3.0 2.1 1 1 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 CDK98280.1 - 2.7e-05 23.6 0.6 0.00042 19.6 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 CDK98280.1 - 0.00036 21.0 0.8 1.5 9.4 0.1 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDK98280.1 - 0.00038 20.6 0.1 0.001 19.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 CDK98280.1 - 0.0041 16.0 0.3 0.89 8.3 0.0 2.6 3 0 0 3 3 3 2 Tryptophan halogenase Pyr_redox_3 PF13738.6 CDK98280.1 - 0.017 14.4 0.4 0.034 13.4 0.2 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 CDK98280.1 - 0.033 12.7 0.0 0.14 10.7 0.0 1.8 2 0 0 2 2 2 0 GDP dissociation inhibitor Lycopene_cycl PF05834.12 CDK98280.1 - 0.13 11.3 1.0 0.57 9.2 1.0 1.8 1 1 0 1 1 1 0 Lycopene cyclase protein ETF_QO PF05187.13 CDK98281.1 - 4e-06 26.9 2.7 4.7e-06 26.7 2.7 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_2 PF12797.7 CDK98281.1 - 3.7 7.8 17.1 0.15 12.3 3.6 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Sel1 PF08238.12 CDK98282.1 - 1.1e-42 143.5 14.5 7.6e-07 29.6 0.1 6.6 6 0 0 6 6 6 6 Sel1 repeat Trypsin_2 PF13365.6 CDK98282.1 - 7.2e-23 82.1 1.8 1.3e-22 81.3 1.8 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDK98282.1 - 4.2e-07 30.0 0.8 1.2e-06 28.5 0.8 1.6 1 1 0 1 1 1 1 Trypsin Peptidase_S29 PF02907.15 CDK98282.1 - 0.026 14.3 0.1 0.05 13.4 0.1 1.4 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease DUF908 PF06012.12 CDK98282.1 - 0.047 13.1 0.4 0.067 12.6 0.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Peptidase_S46 PF10459.9 CDK98282.1 - 0.1 11.2 5.5 6.1 5.3 0.2 3.0 2 1 1 3 3 3 0 Peptidase S46 TPR_16 PF13432.6 CDK98282.1 - 3.2 8.5 21.4 0.3 11.8 1.4 4.6 3 1 2 5 5 5 0 Tetratricopeptide repeat Pyr_redox_2 PF07992.14 CDK98283.1 - 1.8e-23 83.2 0.0 2.5e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 CDK98283.1 - 1.8e-18 66.3 16.1 3.7e-17 62.1 0.0 2.8 2 1 1 3 3 2 2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox PF00070.27 CDK98283.1 - 1.3e-10 41.7 0.2 5.3e-06 26.9 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDK98283.1 - 3.3e-10 40.0 0.0 1e-09 38.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDK98283.1 - 3.1e-08 33.6 0.5 1.2e-07 31.6 0.5 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDK98283.1 - 5.7e-07 29.0 0.1 0.00022 20.4 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 CDK98283.1 - 7.5e-06 25.4 0.0 0.019 14.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4 PF00037.27 CDK98283.1 - 8.8e-06 25.3 3.8 8.8e-06 25.3 3.8 4.2 5 1 1 6 6 4 2 4Fe-4S binding domain Fer4_21 PF14697.6 CDK98283.1 - 1.2e-05 25.4 10.9 1.2e-05 25.4 10.9 2.2 2 1 0 2 2 1 1 4Fe-4S dicluster domain HI0933_like PF03486.14 CDK98283.1 - 2.9e-05 23.0 0.0 6e-05 21.9 0.0 1.5 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 CDK98283.1 - 9.7e-05 21.7 0.3 0.00023 20.5 0.0 1.6 2 0 0 2 2 2 1 Thi4 family Fer4_7 PF12838.7 CDK98283.1 - 0.00025 21.6 15.1 0.00025 21.6 15.1 3.5 2 2 2 4 4 3 1 4Fe-4S dicluster domain FAD_binding_3 PF01494.19 CDK98283.1 - 0.00029 20.2 0.8 0.0055 16.0 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Amino_oxidase PF01593.24 CDK98283.1 - 0.00046 19.6 0.1 0.02 14.2 0.0 2.5 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 CDK98283.1 - 0.00082 19.4 0.0 0.0044 17.0 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_oxidored PF12831.7 CDK98283.1 - 0.0027 17.1 0.0 0.0071 15.7 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 CDK98283.1 - 0.0036 16.5 0.0 0.0051 15.9 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Fer4_9 PF13187.6 CDK98283.1 - 0.0047 17.1 15.2 0.0047 17.1 15.2 3.5 2 2 1 3 3 3 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK98283.1 - 0.0052 16.8 2.9 0.0052 16.8 2.9 4.2 4 1 0 4 4 3 1 4Fe-4S binding domain NAD_binding_7 PF13241.6 CDK98283.1 - 0.0057 17.1 0.1 2.4 8.7 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding Fer4_2 PF12797.7 CDK98283.1 - 0.0081 16.2 0.9 0.0081 16.2 0.9 4.4 4 1 0 4 4 4 1 4Fe-4S binding domain Lycopene_cycl PF05834.12 CDK98283.1 - 0.017 14.2 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Shikimate_DH PF01488.20 CDK98283.1 - 0.033 14.3 0.1 2.4 8.2 0.0 2.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase PALP PF00291.25 CDK98283.1 - 0.062 12.7 0.1 1.6 8.0 0.1 3.1 3 1 0 3 3 3 0 Pyridoxal-phosphate dependent enzyme 2-Hacid_dh_C PF02826.19 CDK98283.1 - 0.1 11.9 0.0 0.35 10.2 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CDK98283.1 - 0.12 11.6 0.6 0.34 10.2 0.0 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 CDK98283.1 - 0.14 12.0 0.1 0.33 10.8 0.0 1.6 2 0 0 2 2 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain BpuJI_N PF11564.8 CDK98283.1 - 0.17 11.0 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal Fer4_10 PF13237.6 CDK98283.1 - 3 8.0 27.1 0.095 12.8 3.1 3.4 3 1 1 4 4 3 0 4Fe-4S dicluster domain TPP_enzyme_C PF02775.21 CDK98284.1 - 3e-25 88.8 0.0 4.2e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 CDK98284.1 - 0.006 15.8 0.0 0.0084 15.4 0.0 1.1 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase DUF3134 PF11332.8 CDK98284.1 - 0.011 16.1 0.2 0.024 15.0 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3134) POR_N PF01855.19 CDK98285.1 - 8e-71 238.4 0.1 1e-70 238.1 0.1 1.1 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg PFOR_II PF17147.4 CDK98285.1 - 9.5e-18 64.4 0.0 2e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Transketolase_C PF02780.20 CDK98285.1 - 9.5e-05 22.3 0.0 0.00017 21.4 0.0 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_N PF02776.18 CDK98285.1 - 0.0009 18.9 0.6 0.0018 17.9 0.6 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain POR PF01558.18 CDK98286.1 - 9.3e-37 126.8 0.0 1.1e-36 126.6 0.0 1.0 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PCMT PF01135.19 CDK98287.1 - 1.3e-35 123.1 0.0 1.6e-35 122.8 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CDK98287.1 - 0.00049 19.9 0.0 0.00074 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 CDK98287.1 - 0.00097 18.3 0.1 0.0018 17.4 0.0 1.4 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 CDK98287.1 - 0.0024 18.5 0.0 0.0059 17.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 CDK98287.1 - 0.032 13.9 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_PK PF05891.12 CDK98287.1 - 0.057 12.9 0.1 0.28 10.6 0.0 1.8 1 1 1 2 2 2 0 AdoMet dependent proline di-methyltransferase OEP PF02321.18 CDK98289.1 - 2e-52 177.8 21.6 5.6e-29 101.3 10.6 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein DUF2497 PF10691.9 CDK98290.1 - 1.3e-25 89.6 0.1 2.7e-25 88.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2497) Trypan_PARP PF05887.11 CDK98290.1 - 0.0018 18.3 33.3 0.0018 18.3 33.3 2.5 1 1 1 2 2 2 1 Procyclic acidic repetitive protein (PARP) tRNA-synt_1 PF00133.22 CDK98291.1 - 4.9e-217 722.0 1.6 6.2e-216 718.3 1.6 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDK98291.1 - 8e-39 133.0 0.0 1.5e-38 132.1 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDK98291.1 - 7e-21 74.4 4.2 1.1e-10 40.8 2.3 3.7 2 2 0 2 2 2 2 tRNA synthetases class I (M) Val_tRNA-synt_C PF10458.9 CDK98291.1 - 6.9e-19 67.9 7.3 1.6e-18 66.7 7.3 1.7 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1_2 PF13603.6 CDK98291.1 - 2.6e-08 33.6 0.1 3.2e-05 23.5 0.0 2.3 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 CDK98291.1 - 2.2e-05 24.0 0.0 0.0041 16.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 CDK98291.1 - 0.0016 17.5 0.0 0.0028 16.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (K) tRNA-synt_1b PF00579.25 CDK98291.1 - 0.014 14.7 1.0 0.92 8.8 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) ABC_tran_CTD PF16326.5 CDK98291.1 - 0.016 15.4 1.6 0.06 13.6 1.4 2.1 2 0 0 2 2 2 0 ABC transporter C-terminal domain GGDEF PF00990.21 CDK98292.1 - 4.2e-50 169.6 0.4 9.9e-50 168.4 0.0 1.8 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDK98292.1 - 2.6e-24 85.4 0.0 9e-13 48.4 0.0 2.8 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 CDK98292.1 - 2.9e-20 72.3 0.0 1e-09 38.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 CDK98292.1 - 3.6e-10 40.1 0.3 3.6e-05 24.0 0.0 3.0 3 0 0 3 3 3 2 PAS fold PAS_3 PF08447.12 CDK98292.1 - 1.8e-09 37.7 0.2 2.8e-07 30.7 0.2 2.9 3 0 0 3 3 3 1 PAS fold PAS_8 PF13188.7 CDK98292.1 - 3.5e-09 36.5 0.1 0.00047 20.1 0.0 3.5 3 0 0 3 3 3 2 PAS domain PilJ PF13675.6 CDK98292.1 - 1.8e-06 28.0 0.7 5.1e-06 26.5 0.2 2.1 2 0 0 2 2 2 1 Type IV pili methyl-accepting chemotaxis transducer N-term Hemerythrin PF01814.23 CDK98293.1 - 7e-11 42.9 2.6 7.8e-11 42.7 2.6 1.0 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain UDG PF03167.19 CDK98294.1 - 1.4e-25 90.1 0.0 1.7e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily DUF3054 PF11255.8 CDK98294.1 - 0.066 13.7 0.1 0.1 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3054) NYN PF01936.18 CDK98295.1 - 5.3e-40 137.3 0.0 6.5e-40 137.0 0.0 1.0 1 0 0 1 1 1 1 NYN domain RNA_pol_Rpb6 PF01192.22 CDK98296.1 - 1.2e-14 54.0 0.1 2.1e-14 53.2 0.1 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb6 HD_4 PF13328.6 CDK98297.1 - 5.3e-46 156.2 0.9 8.6e-46 155.5 0.2 1.7 2 0 0 2 2 2 1 HD domain RelA_SpoT PF04607.17 CDK98297.1 - 9.9e-37 125.8 0.0 2.2e-36 124.7 0.0 1.6 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins ACT_4 PF13291.6 CDK98297.1 - 7.1e-20 71.4 0.8 1.8e-19 70.1 0.8 1.7 1 0 0 1 1 1 1 ACT domain TGS PF02824.21 CDK98297.1 - 2e-19 69.4 0.0 6.6e-19 67.7 0.0 1.9 2 0 0 2 2 2 1 TGS domain HD PF01966.22 CDK98297.1 - 3.9e-08 33.5 0.4 9e-08 32.4 0.4 1.7 1 0 0 1 1 1 1 HD domain ACT PF01842.25 CDK98297.1 - 3e-05 23.7 0.4 0.0001 22.0 0.4 1.9 1 0 0 1 1 1 1 ACT domain PdxJ PF03740.13 CDK98298.1 - 8.8e-98 326.1 2.1 9.9e-98 325.9 2.1 1.0 1 0 0 1 1 1 1 Pyridoxal phosphate biosynthesis protein PdxJ PEP_mutase PF13714.6 CDK98298.1 - 0.003 17.0 0.5 0.0092 15.5 0.1 1.9 1 1 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Glyco_trans_4_4 PF13579.6 CDK98298.1 - 0.028 14.9 7.1 0.42 11.0 1.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain AP_endonuc_2 PF01261.24 CDK98298.1 - 0.058 12.8 2.9 0.63 9.4 2.9 2.6 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel DUF99 PF01949.16 CDK98298.1 - 0.096 12.1 0.9 1.1 8.7 0.1 2.8 2 1 2 4 4 4 0 Protein of unknown function DUF99 Peptidase_S24 PF00717.23 CDK98299.1 - 7.4e-16 57.9 0.0 4.9e-15 55.2 0.0 2.3 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 CDK98299.1 - 3.4e-09 36.6 0.3 0.0015 18.3 0.0 2.5 2 1 0 2 2 2 2 Signal peptidase, peptidase S26 PDZ_6 PF17820.1 CDK98299.1 - 0.11 12.3 0.1 0.79 9.6 0.0 2.1 2 0 0 2 2 2 0 PDZ domain PilN PF05137.13 CDK98299.1 - 0.14 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Fimbrial assembly protein (PilN) Ribonucleas_3_3 PF14622.6 CDK98300.1 - 2.2e-33 115.2 0.0 3e-33 114.7 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 CDK98300.1 - 8.8e-17 61.7 0.0 1.5e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 CDK98300.1 - 3.4e-16 59.7 0.0 8.8e-16 58.4 0.0 1.7 2 0 0 2 2 2 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 CDK98300.1 - 0.072 13.4 0.1 0.21 11.9 0.1 1.8 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 MMR_HSR1 PF01926.23 CDK98301.1 - 9.5e-23 80.5 0.0 1.9e-22 79.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase KH_2 PF07650.17 CDK98301.1 - 1.8e-18 66.1 0.2 3.1e-18 65.4 0.2 1.4 1 0 0 1 1 1 1 KH domain FeoB_N PF02421.18 CDK98301.1 - 1.1e-11 44.5 0.0 1.6e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDK98301.1 - 2.4e-11 43.5 0.8 4.2e-08 33.0 0.2 2.7 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CDK98301.1 - 3.4e-09 37.0 2.3 0.00043 20.4 0.7 2.5 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 CDK98301.1 - 4.8e-09 36.3 0.2 0.0026 17.7 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase PduV-EutP PF10662.9 CDK98301.1 - 1.2e-08 34.8 0.0 3.9e-08 33.1 0.0 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 CDK98301.1 - 0.00028 20.4 0.2 0.11 12.0 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family cobW PF02492.19 CDK98301.1 - 0.00081 19.0 1.0 0.0056 16.3 0.1 2.2 1 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AIG1 PF04548.16 CDK98301.1 - 0.0017 17.7 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 AIG1 family AAA_28 PF13521.6 CDK98301.1 - 0.0021 18.3 1.6 0.12 12.6 0.0 3.1 2 1 0 2 2 2 1 AAA domain MMR_HSR1_Xtn PF16897.5 CDK98301.1 - 0.011 15.7 0.1 0.02 14.9 0.1 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain FtsK_SpoIIIE PF01580.18 CDK98301.1 - 0.078 12.3 0.1 1.3 8.3 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_22 PF13401.6 CDK98301.1 - 0.11 12.8 0.0 0.26 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF3185 PF11381.8 CDK98302.1 - 0.019 14.9 3.7 3 7.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) LapA_dom PF06305.11 CDK98302.1 - 1.2 9.0 8.9 0.95 9.3 1.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF2065 PF09838.9 CDK98302.1 - 4.9 7.3 11.8 2.1 8.5 0.9 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2065) RecO_C PF02565.15 CDK98303.1 - 5e-26 91.4 1.3 5e-26 91.4 1.3 1.5 2 0 0 2 2 2 1 Recombination protein O C terminal RecO_N PF11967.8 CDK98303.1 - 2.3e-15 56.3 0.0 3.6e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Recombination protein O N terminal DNA_topoisoIV PF00521.20 CDK98304.1 - 1.1e-147 492.4 0.0 1.4e-147 492.0 0.0 1.0 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 CDK98304.1 - 5.4e-09 35.4 0.1 0.11 12.0 0.0 3.7 3 0 0 3 3 3 3 DNA gyrase C-terminal domain, beta-propeller DctP PF03480.13 CDK98305.1 - 6.3e-61 206.2 0.0 7.5e-61 206.0 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein, family 7 TAT_signal PF10518.9 CDK98305.1 - 0.003 17.3 1.2 0.0055 16.5 1.2 1.5 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence SBP_bac_8 PF13416.6 CDK98305.1 - 0.013 15.3 1.2 0.031 14.1 1.2 1.6 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein LysR_substrate PF03466.20 CDK98305.1 - 0.087 12.2 0.0 0.35 10.2 0.0 1.9 1 1 0 1 1 1 0 LysR substrate binding domain DDE_Tnp_IS66 PF03050.14 CDK98306.1 - 3.3e-89 299.1 0.9 4.9e-89 298.6 0.0 1.7 2 0 0 2 2 2 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK98306.1 - 2.9e-18 65.8 0.0 1e-17 64.0 0.0 2.0 1 0 0 1 1 1 1 IS66 C-terminal element LZ_Tnp_IS66 PF13007.7 CDK98306.1 - 6.5e-17 62.1 4.4 6.5e-17 62.1 4.4 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDK98306.1 - 1.5e-15 57.3 4.6 2.9e-15 56.4 4.6 1.5 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDK98306.1 - 0.092 12.6 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 TnpB_IS66 PF05717.13 CDK98307.1 - 9.3e-38 128.2 0.0 1e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein HTH_Tnp_1 PF01527.20 CDK98308.1 - 2.4e-16 59.8 0.3 3.3e-16 59.4 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDK98308.1 - 3.3e-06 26.7 0.0 5.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 CDK98308.1 - 0.0068 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 CDK98308.1 - 0.017 15.2 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 CDK98308.1 - 0.039 13.6 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_Tnp_IS630 PF01710.16 CDK98309.1 - 2.5e-08 34.0 0.0 3.2e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK98309.1 - 3e-05 23.6 0.0 6.3e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK98309.1 - 0.00035 20.6 0.1 0.00068 19.7 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK98309.1 - 0.00068 20.2 0.3 0.016 15.8 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK98309.1 - 0.0026 17.7 0.1 0.0045 17.0 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK98309.1 - 0.021 14.6 0.1 0.051 13.4 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDK98310.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK98310.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain DctM PF06808.12 CDK98311.1 - 4.1e-122 408.0 39.7 4.8e-122 407.8 39.7 1.0 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component DctQ PF04290.12 CDK98312.1 - 7.4e-24 84.1 8.9 9.7e-24 83.8 8.9 1.2 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporters, DctQ component DUF308 PF03729.13 CDK98312.1 - 5.3 7.4 14.0 0.44 10.9 3.5 2.9 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) ATE_C PF04377.15 CDK98313.1 - 8.4e-35 120.3 0.1 1.1e-34 120.0 0.1 1.1 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 CDK98313.1 - 1e-13 51.5 0.0 2.5e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.7 CDK98313.1 - 0.0029 17.8 0.4 0.0042 17.2 0.4 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RDD PF06271.12 CDK98314.1 - 4.2e-20 72.4 11.9 5.2e-20 72.1 11.9 1.0 1 0 0 1 1 1 1 RDD family Herpes_LMP1 PF05297.11 CDK98314.1 - 0.99 8.5 8.6 1.3 8.2 8.6 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) MotB_plug PF13677.6 CDK98315.1 - 1.8e-17 62.7 0.2 1.8e-17 62.7 0.2 1.8 2 0 0 2 2 2 1 Membrane MotB of proton-channel complex MotA/MotB OmpA PF00691.20 CDK98315.1 - 3.1e-12 46.7 0.0 5.9e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 OmpA family MotA_ExbB PF01618.16 CDK98316.1 - 3.1e-11 43.1 0.1 6.3e-11 42.1 0.1 1.5 1 0 0 1 1 1 1 MotA/TolQ/ExbB proton channel family DUF4229 PF14012.6 CDK98316.1 - 0.043 13.9 0.2 0.043 13.9 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) Flavin_Reduct PF01613.18 CDK98318.1 - 3.6e-40 137.5 0.0 4.2e-40 137.3 0.0 1.0 1 0 0 1 1 1 1 Flavin reductase like domain DUF447 PF04289.12 CDK98318.1 - 0.2 11.4 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF447) PALP PF00291.25 CDK98319.1 - 2.6e-78 263.4 5.4 6.9e-78 262.0 4.1 1.9 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme ACT PF01842.25 CDK98319.1 - 3.5e-07 29.9 0.1 8e-07 28.7 0.1 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 CDK98319.1 - 1.1e-05 26.0 0.0 4.3e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 ACT domain ACT_6 PF13740.6 CDK98319.1 - 0.078 13.0 0.1 0.4 10.7 0.0 2.2 2 1 0 2 2 2 0 ACT domain Penicil_amidase PF01804.18 CDK98320.1 - 4.7e-219 729.8 10.7 5.9e-219 729.4 10.7 1.0 1 0 0 1 1 1 1 Penicillin amidase Glyoxalase_4 PF13669.6 CDK98321.1 - 1.9e-23 82.8 0.0 2.2e-23 82.6 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 CDK98321.1 - 1.2e-12 48.1 0.0 1.3e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CDK98321.1 - 3.3e-07 30.6 0.0 3.9e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 CDK98321.1 - 0.00015 22.6 0.0 0.0002 22.1 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain DUF1338 PF07063.13 CDK98321.1 - 0.068 12.4 0.0 4.1 6.5 0.0 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF1338) Adenine_glyco PF03352.13 CDK98322.1 - 9.7e-41 139.5 0.0 3.4e-39 134.4 0.0 2.0 1 1 1 2 2 2 2 Methyladenine glycosylase UBA PF00627.31 CDK98323.1 - 0.089 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 UBA/TS-N domain Fer2_4 PF13510.6 CDK98324.1 - 0.089 12.8 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain tRNA-synt_2b PF00587.25 CDK98325.1 - 2e-35 122.4 0.0 2.9e-35 121.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CDK98325.1 - 4.9e-17 61.9 0.0 9.4e-17 61.0 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain MacB_PCD PF12704.7 CDK98326.1 - 2.3e-18 67.3 2.9 2.3e-18 67.3 2.9 1.8 3 0 0 3 3 3 1 MacB-like periplasmic core domain FtsX PF02687.21 CDK98326.1 - 2e-11 44.2 3.5 2e-11 44.2 3.5 3.2 3 0 0 3 3 3 1 FtsX-like permease family NPCC PF08058.11 CDK98326.1 - 0.051 13.6 0.4 0.11 12.6 0.4 1.5 1 0 0 1 1 1 0 Nuclear pore complex component Molydop_binding PF01568.21 CDK98326.1 - 0.072 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain ABC_tran PF00005.27 CDK98327.1 - 6.8e-32 110.8 0.0 8.7e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98327.1 - 6.6e-07 29.4 0.0 0.031 14.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDK98327.1 - 0.00012 21.7 0.0 0.00022 20.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDK98327.1 - 0.0012 19.1 0.1 0.15 12.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDK98327.1 - 0.0013 19.2 0.3 0.0028 18.1 0.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 CDK98327.1 - 0.002 17.6 0.0 0.36 10.2 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_33 PF13671.6 CDK98327.1 - 0.0029 17.8 0.1 0.16 12.1 0.1 2.2 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CDK98327.1 - 0.0033 17.3 0.0 0.0088 16.0 0.0 1.6 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 CDK98327.1 - 0.01 15.4 0.3 0.17 11.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CDK98327.1 - 0.023 14.4 0.0 0.057 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDK98327.1 - 0.051 14.1 0.0 0.075 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CDK98327.1 - 0.17 11.8 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 CDK98327.1 - 0.19 11.8 0.1 0.55 10.3 0.1 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase HATPase_c PF02518.26 CDK98328.1 - 5.6e-26 91.2 0.0 9.3e-26 90.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CHASE PF03924.13 CDK98328.1 - 1.7e-13 50.9 0.0 1.8e-12 47.6 0.0 2.1 1 1 1 2 2 2 1 CHASE domain HisKA PF00512.25 CDK98328.1 - 3.1e-08 33.5 0.6 6.5e-07 29.3 0.0 2.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CDK98328.1 - 4e-07 30.0 0.0 9.5e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 PAS fold HATPase_c_5 PF14501.6 CDK98328.1 - 0.00042 20.2 0.0 0.00081 19.3 0.0 1.4 1 0 0 1 1 1 1 GHKL domain PAS_4 PF08448.10 CDK98328.1 - 0.00064 19.9 0.7 0.012 15.9 0.2 2.9 3 1 0 3 3 3 1 PAS fold PAS_8 PF13188.7 CDK98328.1 - 0.0032 17.5 0.0 0.011 15.7 0.0 2.0 1 0 0 1 1 1 1 PAS domain CopD PF05425.13 CDK98328.1 - 0.011 16.1 4.6 0.05 14.0 0.1 2.9 3 0 0 3 3 3 0 Copper resistance protein D SLATT_1 PF18181.1 CDK98328.1 - 0.02 14.8 1.2 0.02 14.8 1.2 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 DUF4864 PF16156.5 CDK98328.1 - 0.075 13.7 0.0 0.17 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4864) DUF4381 PF14316.6 CDK98328.1 - 0.13 12.5 7.1 8.1 6.7 0.6 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) KxDL PF10241.9 CDK98328.1 - 0.23 11.7 1.7 3.6 7.9 0.5 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein GspL_C PF12693.7 CDK98328.1 - 3.2 7.6 7.4 1.1 9.1 0.4 2.7 3 0 0 3 3 3 0 GspL periplasmic domain DNA_pol3_alpha PF07733.12 CDK98329.1 - 1.8e-100 335.8 0.0 2.8e-100 335.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha NTPase domain DNA_pol3_finger PF17657.1 CDK98329.1 - 3e-64 215.3 0.0 5e-64 214.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha subunit finger domain PHP PF02811.19 CDK98329.1 - 2.3e-35 122.4 0.0 5.8e-35 121.0 0.0 1.8 1 0 0 1 1 1 1 PHP domain HHH_6 PF14579.6 CDK98329.1 - 4.3e-27 94.2 0.3 1.4e-26 92.6 0.1 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif SprA-related PF12118.8 CDK98330.1 - 4.8e-16 58.8 12.3 5.8e-16 58.6 12.3 1.1 1 0 0 1 1 1 1 SprA-related family Kinocilin PF15033.6 CDK98331.1 - 2.1 8.0 7.9 2.7 7.7 7.9 1.2 1 0 0 1 1 1 0 Kinocilin protein Glyco_hydro_17 PF00332.18 CDK98332.1 - 0.00017 21.3 0.7 0.00057 19.6 0.1 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 Lipase_GDSL_2 PF13472.6 CDK98332.1 - 0.0037 17.7 0.1 0.23 11.8 0.0 2.3 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Leader_Trp PF08255.11 CDK98332.1 - 0.48 10.5 4.1 2.3 8.4 4.1 2.2 1 0 0 1 1 1 0 Trp-operon Leader Peptide Pentapeptide PF00805.22 CDK98333.1 - 1.2e-21 76.0 12.5 6.1e-11 41.7 1.1 3.8 2 1 1 4 4 4 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 CDK98333.1 - 3.4e-19 68.8 0.0 3.6e-10 39.9 0.0 2.3 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 CDK98333.1 - 5.1e-08 33.0 0.0 0.00017 21.6 0.0 2.9 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) ALAD PF00490.21 CDK98334.1 - 8.5e-140 465.4 0.1 9.6e-140 465.2 0.1 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Cys_Met_Meta_PP PF01053.20 CDK98335.1 - 4.3e-126 420.5 0.0 4.9e-126 420.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CDK98335.1 - 0.0051 16.2 0.1 0.011 15.1 0.1 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CDK98335.1 - 0.014 14.7 0.1 0.29 10.4 0.1 2.2 1 1 0 1 1 1 0 Beta-eliminating lyase Pro_CA PF00484.19 CDK98339.1 - 3e-50 170.5 0.0 3.5e-50 170.3 0.0 1.0 1 0 0 1 1 1 1 Carbonic anhydrase Radical_SAM PF04055.21 CDK98339.1 - 0.13 12.6 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Radical SAM superfamily DUF218 PF02698.17 CDK98340.1 - 1.2e-25 90.0 0.0 1.5e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain DUF1772 PF08592.11 CDK98340.1 - 0.0022 18.3 0.9 0.0046 17.3 0.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) DUF4131 PF13567.6 CDK98340.1 - 0.0056 16.3 0.9 0.011 15.5 1.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4131) SLT_2 PF13406.6 CDK98341.1 - 5e-110 367.3 0.0 5.7e-110 367.1 0.0 1.0 1 0 0 1 1 1 1 Transglycosylase SLT domain Glucosaminidase PF01832.20 CDK98341.1 - 0.028 14.9 0.0 0.053 14.0 0.0 1.7 1 1 0 1 1 1 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase DPBB_1 PF03330.18 CDK98342.1 - 2e-23 82.4 0.0 4.1e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 Lytic transglycolase SPOR PF05036.13 CDK98342.1 - 1.8e-14 53.9 0.1 5.4e-14 52.3 0.1 1.9 1 0 0 1 1 1 1 Sporulation related domain Peptidase_S11 PF00768.20 CDK98343.1 - 1e-62 211.7 0.0 1.4e-62 211.3 0.0 1.1 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase PBP5_C PF07943.13 CDK98343.1 - 6.5e-13 48.7 0.0 1e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 Penicillin-binding protein 5, C-terminal domain Beta-lactamase2 PF13354.6 CDK98343.1 - 7.5e-11 42.0 0.0 9.3e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase enzyme family Peptidase_S13 PF02113.15 CDK98343.1 - 0.0024 16.7 0.0 0.0041 15.9 0.0 1.3 1 0 0 1 1 1 1 D-Ala-D-Ala carboxypeptidase 3 (S13) family DUF1381 PF07129.11 CDK98343.1 - 0.038 13.8 0.0 0.085 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1381) Beta-lactamase PF00144.24 CDK98343.1 - 0.1 11.8 0.1 2.5 7.3 0.0 2.1 2 0 0 2 2 2 0 Beta-lactamase Thymidylate_kin PF02223.17 CDK98344.1 - 2.9e-48 164.0 0.0 3.3e-48 163.8 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 CDK98344.1 - 6.9e-06 26.4 0.4 1.1e-05 25.7 0.4 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDK98344.1 - 0.0093 16.4 0.7 0.45 10.9 0.7 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDK98344.1 - 0.013 15.8 0.0 0.041 14.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CDK98344.1 - 0.078 12.7 0.1 0.1 12.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain Methyltransf_24 PF13578.6 CDK98344.1 - 0.099 13.7 0.3 1.8 9.6 0.1 2.5 2 1 1 3 3 3 0 Methyltransferase domain DNA_pol3_delta2 PF13177.6 CDK98345.1 - 2.4e-32 112.0 0.0 3.4e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 CDK98345.1 - 1.1e-07 32.3 0.0 3.3e-07 30.8 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CDK98345.1 - 0.00046 20.2 0.1 0.002 18.1 0.1 1.9 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CDK98345.1 - 0.0047 17.3 2.0 0.031 14.6 0.6 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 CDK98345.1 - 0.0051 16.4 0.8 0.018 14.7 0.8 1.9 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CDK98345.1 - 0.015 15.3 0.9 0.77 9.8 0.2 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CDK98345.1 - 0.028 14.2 0.1 0.094 12.4 0.0 1.9 2 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CDK98345.1 - 0.057 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 CDK98345.1 - 0.1 12.5 0.2 0.57 10.1 0.1 2.0 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 CDK98345.1 - 0.23 11.5 0.0 0.61 10.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain tRNA-synt_1g PF09334.11 CDK98346.1 - 3.2e-110 368.5 0.1 2.3e-108 362.4 0.1 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CDK98346.1 - 3.2e-31 108.3 0.4 5.9e-16 57.9 0.0 3.2 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 CDK98346.1 - 4.2e-17 62.4 0.0 2.7e-10 40.1 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 CDK98346.1 - 0.006 16.5 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA TatD_DNase PF01026.21 CDK98347.1 - 2.1e-82 276.3 0.0 2.6e-82 276.0 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 CDK98347.1 - 0.00041 20.2 0.3 0.0053 16.6 0.1 2.7 1 1 0 1 1 1 1 Amidohydrolase AP_endonuc_2 PF01261.24 CDK98347.1 - 0.09 12.2 0.1 2 7.8 0.0 2.5 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel Germane PF10646.9 CDK98347.1 - 0.12 13.1 0.0 0.27 12.0 0.0 1.5 1 0 0 1 1 1 0 Sporulation and spore germination Lactamase_B_2 PF12706.7 CDK98348.1 - 6.7e-30 104.1 1.6 8.7e-30 103.7 1.6 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDK98348.1 - 1e-07 32.1 7.7 4.1e-07 30.2 7.8 2.1 1 1 1 2 2 2 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 CDK98348.1 - 0.047 13.6 0.5 7.1 6.7 0.1 2.4 2 0 0 2 2 2 0 Zn-dependent metallo-hydrolase RNA specificity domain UPF0126 PF03458.13 CDK98349.1 - 6e-45 151.0 26.2 1.4e-23 82.6 4.7 2.4 3 0 0 3 3 3 2 UPF0126 domain Isochorismatase PF00857.20 CDK98350.1 - 2.7e-05 24.4 0.0 0.026 14.7 0.0 3.1 1 1 0 1 1 1 1 Isochorismatase family NUDIX PF00293.28 CDK98351.1 - 0.0001 22.3 0.0 0.00016 21.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NAPRTase PF04095.16 CDK98352.1 - 8.5e-52 176.1 0.0 1.2e-51 175.6 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 CDK98352.1 - 1.1e-24 87.2 0.1 1.6e-24 86.7 0.1 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain CobW_C PF07683.14 CDK98352.1 - 0.1 12.5 0.1 3.3 7.7 0.0 2.5 2 1 0 2 2 2 0 Cobalamin synthesis protein cobW C-terminal domain MazG PF03819.17 CDK98353.1 - 1.4e-40 137.3 1.4 3.5e-29 100.8 0.0 2.2 2 0 0 2 2 2 2 MazG nucleotide pyrophosphohydrolase domain PRA-PH PF01503.17 CDK98353.1 - 1.6e-10 41.3 1.7 0.00019 21.8 0.2 2.5 2 0 0 2 2 2 2 Phosphoribosyl-ATP pyrophosphohydrolase MazG-like PF12643.7 CDK98353.1 - 2.2e-05 24.6 0.3 0.014 15.7 0.1 2.8 2 1 0 2 2 2 2 MazG-like family DUF1353 PF07087.11 CDK98354.1 - 0.032 13.9 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1353) adh_short PF00106.25 CDK98355.1 - 4.8e-54 182.8 0.0 6.2e-54 182.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDK98355.1 - 4.7e-39 134.3 0.3 5.7e-39 134.0 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDK98355.1 - 3.3e-15 56.4 0.1 4.7e-15 56.0 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CDK98355.1 - 1.5e-05 24.6 0.1 4.3e-05 23.1 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CDK98355.1 - 0.0054 15.9 0.0 0.011 14.8 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Inositol_P PF00459.25 CDK98356.1 - 1.4e-38 132.9 0.1 3.6e-38 131.6 0.1 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family GTP-bdg_M PF16360.5 CDK98357.1 - 1.1e-30 106.1 5.0 1.9e-30 105.3 5.0 1.4 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region GTP-bdg_N PF13167.6 CDK98357.1 - 8.1e-25 87.3 0.1 1.9e-24 86.1 0.1 1.6 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal MMR_HSR1 PF01926.23 CDK98357.1 - 1.2e-19 70.5 0.0 3.6e-19 68.9 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDK98357.1 - 0.00042 19.9 0.1 0.0011 18.5 0.0 1.9 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CDK98357.1 - 0.002 18.2 0.0 0.0048 17.0 0.0 1.7 1 1 0 1 1 1 1 Dynamin family AAA_16 PF13191.6 CDK98357.1 - 0.0078 16.6 0.0 0.02 15.3 0.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain cobW PF02492.19 CDK98357.1 - 0.011 15.4 1.5 1.8 8.2 0.1 2.7 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 CDK98357.1 - 0.018 14.9 0.0 0.14 12.0 0.0 2.2 3 0 0 3 3 3 0 RsgA GTPase GTP_EFTU PF00009.27 CDK98357.1 - 0.029 13.9 0.0 7.3 6.1 0.0 2.5 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 CDK98357.1 - 0.039 14.5 0.0 0.1 13.1 0.0 1.7 1 0 0 1 1 1 0 ABC transporter SRPRB PF09439.10 CDK98357.1 - 0.088 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TraI_2B PF18340.1 CDK98357.1 - 0.09 12.9 0.0 1.1 9.4 0.0 2.5 2 1 1 3 3 3 0 DNA relaxase TraI 2B/2B-like domain Hfq PF17209.3 CDK98358.1 - 3.3e-33 113.1 0.2 3.9e-33 112.9 0.2 1.0 1 0 0 1 1 1 1 Hfq protein HAD_2 PF13419.6 CDK98359.1 - 7.8e-33 114.0 0.0 9.1e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 CDK98359.1 - 7.5e-10 39.5 0.2 1e-09 39.0 0.2 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDK98359.1 - 8.7e-07 29.4 0.0 8.1e-06 26.3 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDK98359.1 - 0.0032 17.5 0.0 0.0057 16.7 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 CDK98359.1 - 0.16 12.1 0.0 0.53 10.4 0.0 1.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Aminotran_4 PF01063.19 CDK98360.1 - 8e-50 169.8 0.0 9.4e-50 169.5 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV TrkA_N PF02254.18 CDK98361.1 - 5.2e-52 175.0 4.3 1.6e-26 92.8 0.1 2.5 2 0 0 2 2 2 2 TrkA-N domain TrkA_C PF02080.21 CDK98361.1 - 9.3e-28 95.9 1.2 2.1e-15 56.3 0.0 3.0 2 1 1 3 3 3 2 TrkA-C domain Pyr_redox_2 PF07992.14 CDK98361.1 - 1.4e-09 37.6 1.6 0.0003 20.1 0.3 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CDK98361.1 - 6.5e-09 36.2 7.7 0.00037 20.9 0.3 2.7 3 0 0 3 3 2 2 Putative NAD(P)-binding Pyr_redox PF00070.27 CDK98361.1 - 4.3e-08 33.6 2.0 0.00067 20.2 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CDK98361.1 - 4.7e-08 33.1 1.3 0.00042 20.2 0.1 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CDK98361.1 - 7.6e-08 32.5 0.5 0.0029 17.6 0.0 2.5 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 CDK98361.1 - 6.2e-07 29.9 3.5 0.026 15.1 0.0 3.2 3 1 0 3 3 2 2 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.21 CDK98361.1 - 9.5e-07 28.3 4.6 0.006 15.9 0.3 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 CDK98361.1 - 3e-06 26.2 0.3 0.0036 16.1 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein Sacchrp_dh_NADP PF03435.18 CDK98361.1 - 3.3e-06 27.4 3.7 0.048 13.9 0.4 2.6 2 1 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain XdhC_C PF13478.6 CDK98361.1 - 3.5e-06 27.5 0.8 0.0051 17.3 0.1 2.6 2 0 0 2 2 2 2 XdhC Rossmann domain NAD_binding_10 PF13460.6 CDK98361.1 - 5.7e-06 26.3 3.0 0.0031 17.4 0.2 2.3 2 0 0 2 2 2 2 NAD(P)H-binding ApbA PF02558.16 CDK98361.1 - 1.1e-05 25.1 2.0 0.0068 16.1 0.0 3.0 3 0 0 3 3 3 2 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 CDK98361.1 - 1.7e-05 24.5 1.0 0.0077 15.8 0.1 2.5 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DAO PF01266.24 CDK98361.1 - 5.7e-05 22.9 0.1 0.012 15.2 0.0 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase GFO_IDH_MocA PF01408.22 CDK98361.1 - 6.1e-05 23.8 0.7 0.0021 18.8 0.1 2.7 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold Ldh_1_N PF00056.23 CDK98361.1 - 8.8e-05 22.6 2.4 0.19 11.8 0.1 2.4 2 0 0 2 2 2 2 lactate/malate dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 CDK98361.1 - 0.00021 21.4 0.0 0.04 14.2 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CDK98361.1 - 0.00029 20.1 0.4 0.76 9.0 0.0 2.5 2 1 0 2 2 2 2 Thi4 family Shikimate_DH PF01488.20 CDK98361.1 - 0.00034 20.7 1.9 0.67 10.0 0.1 2.7 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase DUF1188 PF06690.11 CDK98361.1 - 0.00045 19.8 0.4 0.038 13.5 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1188) NAD_binding_2 PF03446.15 CDK98361.1 - 0.00047 20.4 1.0 0.039 14.1 0.1 2.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Lycopene_cycl PF05834.12 CDK98361.1 - 0.00096 18.3 0.1 0.42 9.6 0.1 2.4 2 0 0 2 2 2 2 Lycopene cyclase protein adh_short PF00106.25 CDK98361.1 - 0.0019 17.7 0.5 1.7 8.0 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase Epimerase PF01370.21 CDK98361.1 - 0.014 14.9 0.7 0.092 12.2 0.1 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDK98361.1 - 0.028 13.8 0.1 0.057 12.8 0.1 1.5 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase MTS PF05175.14 CDK98361.1 - 0.04 13.5 1.3 0.69 9.4 0.1 2.2 2 0 0 2 2 2 0 Methyltransferase small domain Glyco_transf_4 PF13439.6 CDK98361.1 - 0.046 13.7 0.7 37 4.3 0.3 3.7 2 1 0 2 2 2 0 Glycosyltransferase Family 4 Gp_dh_N PF00044.24 CDK98361.1 - 0.048 14.0 0.7 2.5 8.5 0.2 2.7 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CDK98361.1 - 0.059 12.6 0.1 0.83 8.8 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain 2-Hacid_dh_C PF02826.19 CDK98361.1 - 0.062 12.6 0.1 5 6.4 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.15 CDK98361.1 - 0.14 11.1 2.2 0.1 11.5 0.4 1.6 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family Sigma54_activat PF00158.26 CDK98362.1 - 5.9e-57 192.0 0.0 8e-57 191.6 0.0 1.2 1 0 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CDK98362.1 - 1.4e-26 92.9 0.1 2.5e-26 92.1 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Sigma54_activ_2 PF14532.6 CDK98362.1 - 2e-24 86.3 0.0 3.3e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CDK98362.1 - 2.6e-09 36.7 0.4 7.3e-09 35.3 0.4 1.8 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CDK98362.1 - 3.4e-06 27.1 0.0 6.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CDK98362.1 - 0.00023 21.6 0.0 0.00044 20.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CDK98362.1 - 0.005 16.3 0.1 3.7 6.9 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 CDK98362.1 - 0.007 16.8 0.1 0.018 15.4 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 CDK98362.1 - 0.076 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 CDK98362.1 - 0.097 12.4 0.1 0.19 11.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDK98362.1 - 0.85 9.9 2.7 4.9 7.5 0.3 2.9 2 1 0 2 2 2 0 AAA domain HATPase_c PF02518.26 CDK98363.1 - 4.1e-19 69.1 0.0 7.2e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 CDK98363.1 - 2e-15 56.9 0.8 7.6e-15 55.0 0.8 2.0 1 0 0 1 1 1 1 HAMP domain PAS_4 PF08448.10 CDK98363.1 - 2.1e-10 40.8 0.1 5e-10 39.6 0.1 1.7 1 0 0 1 1 1 1 PAS fold HisKA PF00512.25 CDK98363.1 - 5e-10 39.3 0.0 1.9e-09 37.4 0.0 2.1 2 0 0 2 2 1 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CDK98363.1 - 1.5e-08 34.6 0.0 3.4e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDK98363.1 - 5.3e-06 26.6 0.0 1.3e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 PAS domain HATPase_c_2 PF13581.6 CDK98363.1 - 9.9e-06 25.5 0.0 2.4e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 CDK98363.1 - 1.4e-05 24.9 0.0 2.7e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 GHKL domain PAS_7 PF12860.7 CDK98363.1 - 9.3e-05 22.6 0.0 0.00031 20.9 0.0 2.0 1 0 0 1 1 1 1 PAS fold dCache_3 PF14827.6 CDK98363.1 - 0.0013 18.4 0.2 0.011 15.4 0.1 2.3 2 0 0 2 2 2 1 Double sensory domain of two-component sensor kinase DUF4199 PF13858.6 CDK98363.1 - 0.014 15.8 1.4 0.59 10.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) HATPase_c_3 PF13589.6 CDK98363.1 - 0.052 13.4 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF456 PF04306.13 CDK98363.1 - 1.5 9.1 13.7 0.25 11.6 8.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF456) DUF2231 PF09990.9 CDK98363.1 - 2.6 8.5 9.2 0.69 10.4 1.4 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2231) Sigma54_activat PF00158.26 CDK98364.1 - 7.8e-71 237.2 0.0 1.2e-70 236.6 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CDK98364.1 - 1.9e-27 96.0 0.0 1.2e-26 93.5 0.0 2.2 2 1 0 2 2 2 1 Sigma-54 interaction domain Response_reg PF00072.24 CDK98364.1 - 8.4e-27 93.6 0.0 1.6e-26 92.7 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HTH_8 PF02954.19 CDK98364.1 - 8.2e-14 51.1 2.9 8.9e-14 51.0 1.4 1.9 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CDK98364.1 - 1.7e-08 34.5 0.0 3.7e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CDK98364.1 - 5.2e-06 26.9 0.0 1.3e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 CDK98364.1 - 1.5e-05 25.2 0.0 2.6e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDK98364.1 - 3.5e-05 24.2 0.2 0.00011 22.6 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain Phage_NinH PF06322.11 CDK98364.1 - 0.0063 16.4 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 Phage NinH protein Mg_chelatase PF01078.21 CDK98364.1 - 0.015 14.7 0.1 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDK98364.1 - 0.019 14.8 0.0 0.043 13.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PutA_N PF18083.1 CDK98364.1 - 0.049 13.7 0.0 0.28 11.2 0.0 2.3 2 0 0 2 2 2 0 Proline utilization A N-terminal domain HTH_30 PF13556.6 CDK98364.1 - 0.057 13.2 0.1 0.15 11.9 0.1 1.7 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_17 PF12728.7 CDK98364.1 - 0.069 13.3 0.0 0.79 10.0 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain HATPase_c PF02518.26 CDK98365.1 - 2.5e-18 66.6 0.0 4.5e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98365.1 - 1e-13 51.1 0.4 2.8e-13 49.7 0.1 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CDK98365.1 - 7.7e-11 42.0 0.0 1.5e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDK98365.1 - 6.6e-06 26.3 0.0 1.5e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDK98365.1 - 0.0001 22.5 0.0 0.0002 21.6 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 CDK98365.1 - 0.0035 17.3 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 PAS domain HATPase_c_5 PF14501.6 CDK98365.1 - 0.015 15.2 0.0 0.071 13.0 0.0 2.1 1 1 0 1 1 1 0 GHKL domain MEIOC PF15189.6 CDK98365.1 - 0.035 13.7 0.1 0.074 12.7 0.1 1.5 1 0 0 1 1 1 0 Meiosis-specific coiled-coil domain-containing protein MEIOC Dus PF01207.17 CDK98366.1 - 2.1e-110 368.6 0.4 2.6e-110 368.3 0.4 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 CDK98366.1 - 7.9e-05 22.0 0.1 0.055 12.7 0.0 2.3 1 1 1 2 2 2 2 Dihydroorotate dehydrogenase FMN_dh PF01070.18 CDK98366.1 - 0.00022 20.4 0.5 0.00022 20.4 0.5 1.7 1 1 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CDK98366.1 - 0.00042 19.4 2.6 0.0037 16.3 0.0 2.1 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NanE PF04131.14 CDK98366.1 - 0.00063 19.0 0.1 0.0023 17.2 0.1 1.8 1 1 1 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 CDK98366.1 - 0.00072 19.1 0.2 0.0013 18.2 0.2 1.6 1 1 0 1 1 1 1 Histidine biosynthesis protein NMO PF03060.15 CDK98366.1 - 0.0015 18.0 1.1 0.0028 17.1 0.2 1.9 2 0 0 2 2 2 1 Nitronate monooxygenase DeoC PF01791.9 CDK98366.1 - 0.0029 17.3 0.6 0.052 13.2 0.6 2.2 1 1 0 1 1 1 1 DeoC/LacD family aldolase PIN_10 PF18478.1 CDK98366.1 - 0.0072 16.5 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 PIN like domain PEP_mutase PF13714.6 CDK98366.1 - 0.01 15.3 2.5 0.093 12.2 0.4 2.8 2 1 0 2 2 2 0 Phosphoenolpyruvate phosphomutase TMP-TENI PF02581.17 CDK98366.1 - 0.018 14.4 0.6 0.059 12.7 0.1 2.2 2 1 1 3 3 3 0 Thiamine monophosphate synthase Cytochrom_C_asm PF01578.20 CDK98367.1 - 8.7e-19 68.1 10.4 1.2e-18 67.7 10.0 1.4 1 1 0 1 1 1 1 Cytochrome C assembly protein IspD PF01128.19 CDK98368.1 - 1.5e-63 214.5 0.7 2e-63 214.1 0.7 1.1 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YgbB PF02542.16 CDK98368.1 - 6.8e-60 201.8 0.0 2e-59 200.3 0.0 1.7 2 0 0 2 2 2 1 YgbB family NTP_transf_3 PF12804.7 CDK98368.1 - 4e-14 53.3 3.0 6.6e-14 52.6 3.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.19 CDK98368.1 - 0.15 11.9 0.0 0.22 11.4 0.0 1.1 1 0 0 1 1 1 0 Cytidylyltransferase CutA1 PF03091.15 CDK98369.1 - 4.3e-36 122.7 0.0 4.8e-36 122.6 0.0 1.0 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Glyco_tran_28_C PF04101.16 CDK98370.1 - 0.21 11.5 0.0 0.38 10.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain MerR_1 PF13411.6 CDK98371.1 - 1.2e-24 86.2 0.0 2e-24 85.4 0.0 1.4 1 0 0 1 1 1 1 MerR HTH family regulatory protein MerR PF00376.23 CDK98371.1 - 8e-08 31.9 0.0 1.8e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 MerR family regulatory protein HTH_Tnp_1 PF01527.20 CDK98371.1 - 0.0014 18.9 0.8 0.0058 16.9 0.0 2.2 2 0 0 2 2 2 1 Transposase Bac_DNA_binding PF00216.21 CDK98372.1 - 2.1e-27 95.2 0.0 2.3e-27 95.0 0.0 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 CDK98372.1 - 2.1e-08 34.3 0.0 2.4e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_euk_1 PF14908.6 CDK98372.1 - 0.0056 16.8 0.0 0.0065 16.6 0.0 1.2 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 1 HU-CCDC81_bac_2 PF18175.1 CDK98372.1 - 0.025 14.4 0.1 0.039 13.8 0.1 1.3 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 FolB PF02152.18 CDK98372.1 - 0.064 13.8 0.1 0.083 13.4 0.1 1.1 1 0 0 1 1 1 0 Dihydroneopterin aldolase DUF2267 PF10025.9 CDK98372.1 - 0.072 13.4 0.3 0.11 12.8 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) ACP_syn_III_C PF08541.10 CDK98373.1 - 1.9e-37 127.3 0.1 2.1e-36 124.0 0.1 2.3 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 CDK98373.1 - 4.6e-33 112.9 0.8 1e-32 111.8 0.3 1.9 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 CDK98373.1 - 2.1e-07 30.6 4.3 3.9e-07 29.7 0.4 2.3 2 1 1 3 3 3 1 Thiolase, N-terminal domain FAE1_CUT1_RppA PF08392.12 CDK98373.1 - 7.2e-05 22.2 0.0 0.00025 20.4 0.0 1.8 2 0 0 2 2 2 1 FAE1/Type III polyketide synthase-like protein FA_synthesis PF02504.15 CDK98374.1 - 3.8e-111 371.2 0.9 4.3e-111 371.0 0.9 1.0 1 0 0 1 1 1 1 Fatty acid synthesis protein Ribosomal_L32p PF01783.23 CDK98375.1 - 1e-29 102.5 5.4 1.2e-29 102.4 5.4 1.0 1 0 0 1 1 1 1 Ribosomal L32p protein family OrfB_Zn_ribbon PF07282.11 CDK98375.1 - 0.0045 16.9 2.3 0.0087 16.0 2.3 1.6 1 1 0 1 1 1 1 Putative transposase DNA-binding domain DZR PF12773.7 CDK98375.1 - 0.012 15.6 0.8 0.017 15.2 0.8 1.3 1 0 0 1 1 1 0 Double zinc ribbon Stc1 PF12898.7 CDK98375.1 - 0.045 14.3 0.4 0.05 14.2 0.4 1.1 1 0 0 1 1 1 0 Stc1 domain zf-ribbon_3 PF13248.6 CDK98375.1 - 0.053 12.9 7.9 0.24 10.8 7.9 1.9 1 1 0 1 1 1 0 zinc-ribbon domain Zn_Tnp_IS91 PF14319.6 CDK98375.1 - 0.065 13.3 1.3 0.079 13.0 1.3 1.3 1 1 0 1 1 1 0 Transposase zinc-binding domain DUF1610 PF07754.11 CDK98375.1 - 0.076 13.0 0.9 0.076 13.0 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zinc_ribbon_2 PF13240.6 CDK98375.1 - 0.11 12.2 4.0 0.55 10.0 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.13 CDK98375.1 - 0.16 11.7 2.0 1.9 8.2 0.0 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Zn-ribbon_8 PF09723.10 CDK98375.1 - 0.52 10.5 4.6 1.6 8.9 0.4 2.2 1 1 1 2 2 2 0 Zinc ribbon domain YhfH PF14149.6 CDK98375.1 - 0.71 9.9 5.3 3.5 7.7 0.2 2.4 1 1 1 2 2 2 0 YhfH-like protein zinc_ribbon_4 PF13717.6 CDK98375.1 - 0.75 9.8 5.1 1.1 9.2 0.0 2.7 3 0 0 3 3 3 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 CDK98375.1 - 3 7.4 8.1 35 4.0 8.1 2.1 1 1 0 1 1 1 0 TFIIB zinc-binding YceD PF02620.17 CDK98376.1 - 2.3e-17 63.2 0.3 4.1e-17 62.4 0.3 1.4 1 1 0 1 1 1 1 Large ribosomal RNA subunit accumulation protein YceD Ubiq_cyt_C_chap PF03981.12 CDK98377.1 - 2e-43 147.8 0.8 2.7e-43 147.4 0.8 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone SmpA_OmlA PF04355.13 CDK98378.1 - 2e-15 56.3 0.0 2.6e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 SmpA / OmlA family DUF4223 PF13978.6 CDK98378.1 - 0.00032 20.6 0.0 0.00059 19.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4223) H_PPase PF03030.16 CDK98379.1 - 1.4e-264 879.8 51.2 1.6e-264 879.5 51.2 1.0 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase DUF3149 PF11346.8 CDK98380.1 - 0.36 10.5 4.6 3.2 7.4 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) AIRS PF00586.24 CDK98381.1 - 2.9e-23 82.3 0.3 5.8e-23 81.4 0.3 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.22 CDK98381.1 - 2.5e-11 43.9 0.2 3.7e-11 43.4 0.2 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain NusB PF01029.18 CDK98382.1 - 1.5e-26 93.3 0.0 1.7e-26 93.1 0.0 1.0 1 0 0 1 1 1 1 NusB family DUF3849 PF12960.7 CDK98382.1 - 0.088 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3849) DMRL_synthase PF00885.19 CDK98383.1 - 7.6e-39 132.8 0.2 8.4e-39 132.6 0.2 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase DHBP_synthase PF00926.19 CDK98384.1 - 7.4e-81 270.3 0.4 1.2e-80 269.6 0.4 1.3 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase GTP_cyclohydro2 PF00925.20 CDK98384.1 - 5.6e-36 123.6 0.0 1.4e-35 122.3 0.0 1.6 1 1 0 1 1 1 1 GTP cyclohydrolase II Thymidylate_kin PF02223.17 CDK98384.1 - 0.0052 16.5 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 Thymidylate kinase Lum_binding PF00677.17 CDK98385.1 - 7.4e-48 160.5 0.7 9.6e-26 89.6 0.0 2.0 2 0 0 2 2 2 2 Lumazine binding domain RibD_C PF01872.17 CDK98386.1 - 2.2e-47 161.5 0.3 3.5e-47 160.8 0.3 1.2 1 0 0 1 1 1 1 RibD C-terminal domain dCMP_cyt_deam_1 PF00383.23 CDK98386.1 - 5.7e-16 58.2 0.0 1.2e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDK98386.1 - 3.1e-09 36.7 0.0 5.1e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase Inv-AAD PF18785.1 CDK98386.1 - 0.00093 19.1 0.0 0.0027 17.5 0.0 1.8 2 0 0 2 2 2 1 Invertebrate-AID/APOBEC-deaminase CutC PF03932.14 CDK98386.1 - 0.012 15.1 0.4 0.048 13.1 0.0 2.1 3 0 0 3 3 3 0 CutC family ATP-cone PF03477.16 CDK98387.1 - 2.1e-19 69.8 0.1 2.8e-19 69.5 0.1 1.2 1 0 0 1 1 1 1 ATP cone domain TF_Zn_Ribbon PF08271.12 CDK98387.1 - 4.8e-05 22.8 2.2 0.19 11.2 0.3 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding zf-ribbon_3 PF13248.6 CDK98387.1 - 0.0015 17.8 0.5 1.2 8.7 0.0 2.3 2 0 0 2 2 2 2 zinc-ribbon domain Lar_restr_allev PF14354.6 CDK98387.1 - 0.0016 18.7 1.2 0.005 17.2 1.3 1.7 1 1 0 1 1 1 1 Restriction alleviation protein Lar TFIIS_C PF01096.18 CDK98387.1 - 0.0024 17.7 1.1 0.047 13.6 0.1 2.2 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) zf-ISL3 PF14690.6 CDK98387.1 - 0.0046 17.6 2.1 1.4 9.6 0.1 2.5 2 0 0 2 2 2 2 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Ogr_Delta PF04606.12 CDK98387.1 - 0.011 15.7 0.3 2.4 8.2 0.0 2.3 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger UPF0547 PF10571.9 CDK98387.1 - 0.012 15.7 4.0 0.72 10.0 0.2 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 DUF3268 PF11672.8 CDK98387.1 - 0.081 13.3 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 zinc-finger-containing domain A2L_zn_ribbon PF08792.10 CDK98387.1 - 0.19 11.5 0.5 7.2 6.5 0.0 2.5 3 0 0 3 3 3 0 A2L zinc ribbon domain Cys_rich_CPXG PF14255.6 CDK98387.1 - 0.22 11.4 0.7 9.9 6.2 0.1 2.3 2 0 0 2 2 2 0 Cysteine-rich CPXCG Zn-ribbon_8 PF09723.10 CDK98387.1 - 0.32 11.2 4.9 1.6 8.9 4.8 2.2 1 1 0 1 1 1 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 CDK98387.1 - 0.33 11.0 6.0 3.8 7.6 0.7 2.2 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Nudix_N_2 PF14803.6 CDK98387.1 - 0.37 10.7 3.2 1.2 9.1 3.2 1.8 1 1 0 1 1 1 0 Nudix N-terminal zinc_ribbon_9 PF14369.6 CDK98387.1 - 0.4 11.0 0.1 0.4 11.0 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon DUF35_N PF12172.8 CDK98387.1 - 0.73 9.8 5.5 2.2 8.2 0.7 2.3 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc_ribbon_2 PF13240.6 CDK98387.1 - 1.2 9.0 4.8 12 5.7 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DNA_ligase_ZBD PF03119.16 CDK98387.1 - 5.6 7.1 8.0 2.5 8.2 0.2 2.9 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain SHMT PF00464.19 CDK98388.1 - 1.6e-178 593.3 0.0 1.9e-178 593.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 CDK98388.1 - 2.5e-06 26.9 0.0 3.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CDK98388.1 - 2.9e-06 26.8 0.1 4.9e-06 26.0 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CDK98388.1 - 8.4e-06 25.3 0.1 1.4e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family LacAB_rpiB PF02502.18 CDK98389.1 - 8e-52 174.9 0.0 9e-52 174.8 0.0 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase ACP_syn_III_C PF08541.10 CDK98389.1 - 0.087 13.0 0.2 0.6 10.3 0.1 2.0 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ROS_MUCR PF05443.11 CDK98390.1 - 1.2e-49 167.5 0.0 1.5e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 ROS/MUCR transcriptional regulator protein ACR_tran PF00873.19 CDK98392.1 - 2e-299 995.8 20.7 2.3e-299 995.6 20.7 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 CDK98392.1 - 3.4e-14 52.5 34.4 2.6e-09 36.5 17.1 2.5 2 0 0 2 2 2 2 MMPL family Gemini_mov PF01708.16 CDK98392.1 - 1 9.2 4.6 7.8 6.3 0.0 3.7 3 0 0 3 3 3 0 Geminivirus putative movement protein HlyD_D23 PF16576.5 CDK98393.1 - 3.1e-31 108.3 0.9 4e-31 107.9 0.9 1.1 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CDK98393.1 - 2.8e-16 60.1 5.0 5.9e-14 52.7 0.2 2.9 3 0 0 3 3 3 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDK98393.1 - 4.3e-11 42.5 7.0 1.1e-10 41.1 0.3 3.0 3 0 0 3 3 3 2 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK98393.1 - 0.00053 19.8 0.8 0.55 10.1 0.1 3.5 3 0 0 3 3 3 2 Biotin-requiring enzyme GGDEF PF00990.21 CDK98394.1 - 2.8e-18 66.2 0.0 4.1e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Response_reg PF00072.24 CDK98394.1 - 0.00078 19.6 0.0 0.11 12.7 0.0 2.9 3 0 0 3 3 3 2 Response regulator receiver domain DSBA PF01323.20 CDK98395.1 - 4.1e-35 121.3 0.0 4.6e-35 121.2 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 CDK98395.1 - 0.00036 20.5 0.0 0.049 13.7 0.0 2.9 3 1 1 4 4 4 1 Thioredoxin domain Thioredoxin_4 PF13462.6 CDK98395.1 - 0.019 15.1 0.0 0.087 13.0 0.0 1.9 2 1 0 2 2 2 0 Thioredoxin TRCF PF03461.15 CDK98396.1 - 1.4e-27 95.9 0.0 2.1e-26 92.1 0.0 2.4 2 0 0 2 2 2 1 TRCF domain CarD_CdnL_TRCF PF02559.16 CDK98396.1 - 2.2e-24 86.0 0.0 7.5e-24 84.3 0.0 2.0 1 0 0 1 1 1 1 CarD-like/TRCF domain UvrB_inter PF17757.1 CDK98396.1 - 2.4e-19 69.3 0.0 5.3e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 UvrB interaction domain Helicase_C PF00271.31 CDK98396.1 - 2.3e-18 66.5 0.0 1.2e-16 61.1 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDK98396.1 - 6.4e-18 65.1 0.0 2.3e-17 63.3 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CDK98396.1 - 6e-07 29.6 0.0 1.2e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 CDK98396.1 - 0.013 14.8 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 SecA DEAD-like domain UB2H PF14814.6 CDK98396.1 - 0.016 15.2 0.0 0.056 13.5 0.0 1.9 1 1 0 1 1 1 0 Bifunctional transglycosylase second domain AAA_22 PF13401.6 CDK98396.1 - 0.088 13.1 0.1 14 5.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain Sdh5 PF03937.16 CDK98397.1 - 1.5e-22 79.3 0.0 1.8e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase Helicase_C PF00271.31 CDK98398.1 - 4.3e-18 65.7 0.0 5.8e-14 52.4 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 CDK98398.1 - 1.2e-17 64.2 0.2 1.6e-16 60.5 0.2 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CDK98398.1 - 3.2e-07 30.5 0.0 4.8e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RecG_wedge PF17191.4 CDK98398.1 - 1.4e-05 24.7 0.0 2.5e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 RecG wedge domain tRNA_anti-codon PF01336.25 CDK98398.1 - 0.0003 20.7 0.0 0.00072 19.5 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain SNF2_N PF00176.23 CDK98398.1 - 0.00041 19.2 0.0 0.00069 18.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain SecA_DEAD PF07517.14 CDK98398.1 - 0.0025 17.1 0.0 0.0043 16.4 0.0 1.3 1 0 0 1 1 1 1 SecA DEAD-like domain Senescence_reg PF04520.13 CDK98398.1 - 0.073 13.9 0.0 0.18 12.6 0.0 1.6 1 0 0 1 1 1 0 Senescence regulator TsaE PF02367.17 CDK98398.1 - 0.16 12.0 0.0 0.38 10.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CDK98398.1 - 1.1 8.9 6.1 0.57 9.9 3.1 2.0 2 0 0 2 2 2 0 AAA domain DUF502 PF04367.13 CDK98399.1 - 2.3e-35 120.7 0.7 3.8e-35 120.0 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF502) N_methyl PF07963.12 CDK98399.1 - 0.13 11.9 4.6 0.27 10.9 4.6 1.6 1 0 0 1 1 1 0 Prokaryotic N-terminal methylation motif HlyD_3 PF13437.6 CDK98400.1 - 3.8e-17 62.9 0.2 1.3e-12 48.3 0.0 2.9 3 0 0 3 3 3 2 HlyD family secretion protein HlyD_D23 PF16576.5 CDK98400.1 - 8.2e-07 28.5 9.4 1.7e-06 27.4 0.9 2.6 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl PF00364.22 CDK98400.1 - 3e-05 23.8 4.1 0.0042 16.9 0.7 3.5 3 0 0 3 3 3 2 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDK98400.1 - 0.00011 21.9 0.1 0.00011 21.9 0.1 3.3 5 0 0 5 5 5 1 Biotin-lipoyl like FliJ PF02050.16 CDK98400.1 - 0.0073 16.5 1.4 0.0073 16.5 1.4 2.7 1 1 0 2 2 2 1 Flagellar FliJ protein HlyD PF00529.20 CDK98400.1 - 0.044 13.7 0.0 0.06 13.2 0.0 1.2 1 0 0 1 1 1 0 HlyD membrane-fusion protein of T1SS CSD2 PF17876.1 CDK98400.1 - 0.096 12.9 0.1 17 5.7 0.0 2.6 2 0 0 2 2 2 0 Cold shock domain DUF2730 PF10805.8 CDK98400.1 - 0.53 10.4 3.1 1 9.5 1.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) ABC_membrane PF00664.23 CDK98401.1 - 5.4e-26 91.9 11.8 7.1e-26 91.5 11.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDK98401.1 - 5.9e-24 85.1 0.0 1.2e-23 84.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98401.1 - 4.1e-07 30.1 0.0 0.034 14.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK98401.1 - 6.8e-06 25.7 0.0 0.095 12.1 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDK98401.1 - 0.00014 21.5 0.0 0.00028 20.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CDK98401.1 - 0.0042 16.4 0.0 0.0079 15.5 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_23 PF13476.6 CDK98401.1 - 0.015 15.8 0.0 0.025 15.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDK98401.1 - 0.079 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Peptidase_C39 PF03412.15 CDK98401.1 - 0.17 11.7 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase C39 family AAA_15 PF13175.6 CDK98401.1 - 0.25 11.0 0.0 0.37 10.4 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain ABC_membrane_3 PF13748.6 CDK98401.1 - 1.4 8.0 5.8 2.8 7.1 5.8 1.5 1 1 0 1 1 1 0 ABC transporter transmembrane region ABC_membrane PF00664.23 CDK98402.1 - 2.1e-29 103.0 7.3 2.9e-29 102.6 7.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDK98402.1 - 2e-27 96.4 0.0 3.3e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter Zeta_toxin PF06414.12 CDK98402.1 - 8.2e-05 22.0 0.0 0.00016 21.1 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 CDK98402.1 - 0.0015 18.9 0.0 0.0029 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDK98402.1 - 0.0017 18.1 0.1 0.0045 16.7 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CDK98402.1 - 0.0047 16.4 0.1 3.2 7.1 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDK98402.1 - 0.012 16.2 0.1 0.019 15.4 0.1 1.2 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDK98402.1 - 0.015 15.2 0.1 0.8 9.6 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_21 PF13304.6 CDK98402.1 - 0.015 15.1 0.0 0.048 13.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 CDK98402.1 - 0.033 13.2 0.0 0.057 12.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DLIC PF05783.11 CDK98402.1 - 0.044 12.6 0.0 0.068 12.0 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_28 PF13521.6 CDK98402.1 - 0.16 12.2 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain DNA_pol3_delta2 PF13177.6 CDK98402.1 - 0.21 11.3 0.0 0.42 10.4 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Keratin_assoc PF09775.9 CDK98402.1 - 0.53 9.9 3.6 0.15 11.7 0.3 1.8 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 Peptidase_M20 PF01546.28 CDK98403.1 - 5.7e-32 111.1 0.0 1.3e-31 109.9 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDK98403.1 - 1e-24 86.6 0.0 1.7e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CDK98403.1 - 0.0037 17.0 0.0 0.0092 15.7 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M42 PF05343.14 CDK98403.1 - 0.055 12.5 0.0 0.32 10.0 0.0 2.0 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase EamA PF00892.20 CDK98404.1 - 5.6e-28 97.8 35.2 2.5e-15 56.8 11.1 2.0 2 0 0 2 2 2 2 EamA-like transporter family Multi_Drug_Res PF00893.19 CDK98404.1 - 1.7 9.4 16.3 0.67 10.7 0.8 4.1 4 1 0 4 4 4 0 Small Multidrug Resistance protein BON PF04972.17 CDK98405.1 - 1.5e-06 28.4 3.9 0.00098 19.4 1.3 2.5 2 1 0 2 2 2 2 BON domain HTH_11 PF08279.12 CDK98406.1 - 9.1e-06 25.5 0.0 2.7e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 HTH domain Sugarporin_N PF11471.8 CDK98406.1 - 0.00023 21.1 2.6 0.0034 17.3 0.1 2.5 2 0 0 2 2 2 1 Maltoporin periplasmic N-terminal extension Sigma70_r4 PF04545.16 CDK98406.1 - 0.0016 17.9 0.2 0.011 15.2 0.0 2.4 3 0 0 3 3 3 1 Sigma-70, region 4 HTH_AsnC-type PF13404.6 CDK98406.1 - 0.0093 15.8 0.0 0.031 14.1 0.0 2.0 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_23 PF13384.6 CDK98406.1 - 0.015 15.1 0.1 0.061 13.1 0.1 2.1 2 0 0 2 2 2 0 Homeodomain-like domain HTH_10 PF04967.12 CDK98406.1 - 0.017 14.9 0.0 0.04 13.7 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain HTH_24 PF13412.6 CDK98406.1 - 0.026 14.1 0.0 0.057 13.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_WhiA PF02650.14 CDK98406.1 - 0.079 13.3 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 WhiA C-terminal HTH domain HTH_38 PF13936.6 CDK98406.1 - 0.14 11.9 0.2 1.4 8.8 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain Glyoxalase PF00903.25 CDK98407.1 - 9.8e-24 84.0 0.0 1.1e-23 83.8 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CDK98407.1 - 2.7e-13 50.2 0.0 8.9e-13 48.5 0.0 1.7 1 1 1 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CDK98407.1 - 6e-07 30.2 0.0 1e-06 29.5 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CDK98407.1 - 0.00017 21.8 0.0 0.0072 16.5 0.0 2.1 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CDK98407.1 - 0.022 14.7 0.0 0.069 13.1 0.0 1.7 1 1 0 1 1 1 0 Glyoxalase-like domain CppA_N PF14506.6 CDK98407.1 - 0.081 13.0 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 CppA N-terminal LpxB PF02684.15 CDK98408.1 - 2e-92 310.0 0.0 2.2e-92 309.8 0.0 1.0 1 0 0 1 1 1 1 Lipid-A-disaccharide synthetase LpxI_C PF06230.11 CDK98409.1 - 1.5e-48 164.0 0.1 2e-48 163.5 0.1 1.2 1 0 0 1 1 1 1 LpxI C-terminal domain LpxI_N PF17930.1 CDK98409.1 - 4.7e-37 126.8 0.0 7.4e-37 126.1 0.0 1.3 1 0 0 1 1 1 1 LpxI N-terminal domain Acetyltransf_11 PF13720.6 CDK98410.1 - 1.4e-25 89.5 0.0 2.3e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Hexapep PF00132.24 CDK98410.1 - 1.1e-23 82.0 8.1 2.7e-08 33.2 0.4 5.9 6 0 0 6 6 6 5 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDK98410.1 - 8.8e-07 28.6 6.7 0.047 13.4 0.2 4.4 5 0 0 5 5 5 3 Hexapeptide repeat of succinyl-transferase DUF2407_C PF13373.6 CDK98410.1 - 0.067 13.4 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain FabA PF07977.13 CDK98411.1 - 2e-35 121.4 0.1 2.5e-35 121.1 0.1 1.1 1 0 0 1 1 1 1 FabA-like domain 4HBT PF03061.22 CDK98411.1 - 0.00011 22.5 0.0 0.0006 20.1 0.0 2.1 1 1 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.19 CDK98411.1 - 0.027 14.0 0.0 0.043 13.4 0.0 1.5 1 1 0 1 1 1 0 MaoC like domain Hexapep PF00132.24 CDK98412.1 - 1.7e-29 100.4 44.6 9.1e-12 44.2 5.9 6.4 4 1 2 6 6 6 6 Bacterial transferase hexapeptide (six repeats) LpxD PF04613.14 CDK98412.1 - 2.8e-20 71.9 0.2 4.6e-20 71.2 0.2 1.4 1 0 0 1 1 1 1 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD Hexapep_2 PF14602.6 CDK98412.1 - 8.8e-10 38.2 39.1 1.1e-07 31.4 5.2 5.6 4 1 1 5 5 5 3 Hexapeptide repeat of succinyl-transferase OmpH PF03938.14 CDK98413.1 - 6.4e-20 71.9 4.1 7.6e-20 71.7 4.1 1.1 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) SHE3 PF17078.5 CDK98413.1 - 0.0001 22.1 0.4 0.00013 21.8 0.4 1.1 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Lant_dehydr_C PF14028.6 CDK98413.1 - 0.055 13.0 1.1 0.068 12.7 1.1 1.1 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term Bac_surface_Ag PF01103.23 CDK98414.1 - 1.6e-69 234.9 7.3 3e-69 234.0 7.3 1.5 1 0 0 1 1 1 1 Surface antigen POTRA PF07244.15 CDK98414.1 - 4.8e-67 222.5 17.8 3.6e-16 59.5 0.0 5.6 5 0 0 5 5 5 5 Surface antigen variable number repeat POTRA_1 PF08478.10 CDK98414.1 - 1.3e-06 28.6 1.1 0.29 11.5 0.0 4.4 4 0 0 4 4 4 2 POTRA domain, FtsQ-type POTRA_2 PF08479.11 CDK98414.1 - 0.00027 20.7 2.6 0.26 11.1 0.0 4.4 5 0 0 5 5 5 2 POTRA domain, ShlB-type Peptidase_M50 PF02163.22 CDK98415.1 - 7.4e-78 261.3 1.1 8.7e-78 261.0 1.1 1.0 1 0 0 1 1 1 1 Peptidase family M50 PDZ_6 PF17820.1 CDK98415.1 - 6.4e-12 45.1 0.4 1.3e-11 44.2 0.4 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDK98415.1 - 4.5e-07 30.1 0.0 1.2e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDK98415.1 - 1.9e-06 28.2 0.1 3.3e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Peptidase_M50B PF13398.6 CDK98415.1 - 0.065 12.9 0.2 0.065 12.9 0.2 2.8 3 1 0 4 4 4 0 Peptidase M50B-like GRASP55_65 PF04495.14 CDK98415.1 - 0.16 12.3 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain DXPR_C PF13288.6 CDK98416.1 - 2.3e-40 137.5 0.0 3.7e-40 136.8 0.0 1.4 1 0 0 1 1 1 1 DXP reductoisomerase C-terminal domain DXP_redisom_C PF08436.12 CDK98416.1 - 3e-40 136.3 0.1 7.5e-40 135.0 0.1 1.7 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain DXP_reductoisom PF02670.16 CDK98416.1 - 3.5e-37 128.0 0.4 8.1e-37 126.8 0.4 1.6 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DUF2537 PF10801.8 CDK98416.1 - 0.16 12.2 3.8 0.61 10.4 0.9 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2537) CTP_transf_1 PF01148.20 CDK98417.1 - 1.5e-52 179.0 16.5 2.1e-52 178.5 16.5 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family CarS-like PF01864.17 CDK98417.1 - 0.0086 16.1 0.8 0.02 14.9 0.8 1.8 1 1 0 1 1 1 1 CDP-archaeol synthase Prenyltransf PF01255.19 CDK98418.1 - 9.3e-83 277.2 0.0 1e-82 277.0 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase RRF PF01765.19 CDK98419.1 - 2.1e-61 206.6 1.3 2.5e-61 206.3 1.3 1.1 1 0 0 1 1 1 1 Ribosome recycling factor 14-3-3 PF00244.20 CDK98419.1 - 0.0073 15.8 1.6 0.01 15.3 1.6 1.2 1 0 0 1 1 1 1 14-3-3 protein DUF883 PF05957.13 CDK98419.1 - 0.14 12.7 2.7 0.4 11.3 1.9 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) HSCB_C PF07743.13 CDK98419.1 - 0.42 11.1 4.0 26 5.4 1.8 2.9 2 1 1 3 3 3 0 HSCB C-terminal oligomerisation domain YtxH PF12732.7 CDK98419.1 - 2.5 8.7 4.7 11 6.6 3.8 2.3 2 0 0 2 2 2 0 YtxH-like protein AA_kinase PF00696.28 CDK98420.1 - 1.3e-27 96.9 0.8 1.5e-27 96.7 0.8 1.0 1 0 0 1 1 1 1 Amino acid kinase family Radical_SAM PF04055.21 CDK98420.1 - 0.15 12.4 0.0 0.49 10.7 0.0 2.0 1 1 1 2 2 2 0 Radical SAM superfamily WSN PF02206.18 CDK98420.1 - 0.18 11.7 0.2 0.55 10.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function EF_TS PF00889.19 CDK98421.1 - 1.3e-67 227.4 0.9 1.8e-67 227.0 0.9 1.2 1 0 0 1 1 1 1 Elongation factor TS HOIP-UBA PF16678.5 CDK98421.1 - 0.0067 16.4 0.4 0.021 14.8 0.1 1.9 2 0 0 2 2 2 1 HOIP UBA domain pair UBA PF00627.31 CDK98421.1 - 0.063 13.2 0.0 0.19 11.7 0.0 1.9 1 0 0 1 1 1 0 UBA/TS-N domain T3SchapCesA PF11439.8 CDK98421.1 - 0.11 12.7 0.1 0.26 11.5 0.1 1.6 1 0 0 1 1 1 0 Type III secretion system filament chaperone CesA Ribosomal_S2 PF00318.20 CDK98422.1 - 3.4e-92 307.5 0.0 3.9e-92 307.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S2 Peptidase_M74 PF03411.13 CDK98423.1 - 6.4e-90 300.9 0.0 7.4e-90 300.7 0.0 1.0 1 0 0 1 1 1 1 Penicillin-insensitive murein endopeptidase HD PF01966.22 CDK98424.1 - 3e-18 66.2 0.1 5.1e-18 65.5 0.1 1.4 1 0 0 1 1 1 1 HD domain HD_5 PF13487.6 CDK98424.1 - 3.5e-14 52.8 0.0 8.7e-14 51.5 0.0 1.7 1 0 0 1 1 1 1 HD domain GAF_2 PF13185.6 CDK98424.1 - 3e-05 24.3 0.0 5.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 CDK98424.1 - 0.027 15.1 0.0 0.058 14.0 0.0 1.6 1 0 0 1 1 1 0 GAF domain DAGK_cat PF00781.24 CDK98425.1 - 5.5e-19 68.0 0.0 7.8e-19 67.5 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 CDK98425.1 - 0.0031 16.8 0.2 0.006 15.8 0.1 1.5 2 0 0 2 2 2 1 ATP-NAD kinase PS_pyruv_trans PF04230.13 CDK98425.1 - 0.017 15.0 0.0 0.035 14.0 0.0 1.4 2 0 0 2 2 2 0 Polysaccharide pyruvyl transferase PGK PF00162.19 CDK98425.1 - 0.11 11.4 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Phosphoglycerate kinase Metallophos PF00149.28 CDK98426.1 - 9.2e-15 55.7 7.2 1.3e-14 55.2 7.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDK98426.1 - 9.1e-11 42.2 7.0 3.6e-10 40.3 7.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 CDK98426.1 - 0.0041 16.5 0.1 0.3 10.4 0.1 2.7 1 1 1 2 2 2 2 Metallophosphoesterase, calcineurin superfamily TPP_enzyme_M PF00205.22 CDK98426.1 - 0.046 13.5 0.0 0.069 12.9 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Cytochrome_CBB3 PF13442.6 CDK98427.1 - 1.1e-12 48.1 0.1 1.6e-12 47.6 0.1 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDK98427.1 - 7.2e-09 36.7 0.0 1e-08 36.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrom_C1 PF02167.15 CDK98427.1 - 0.0056 16.4 0.2 0.0083 15.9 0.2 1.2 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrom_C550 PF14495.6 CDK98427.1 - 0.022 14.4 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c-550 domain DUF1641 PF07849.11 CDK98427.1 - 0.11 12.4 0.3 20 5.2 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1641) ACT PF01842.25 CDK98428.1 - 2.9e-16 58.9 0.3 1.5e-06 27.8 0.1 3.0 2 1 0 2 2 2 2 ACT domain ACT_6 PF13740.6 CDK98428.1 - 6.3e-13 48.5 0.1 2.4e-06 27.4 0.0 2.2 2 0 0 2 2 2 2 ACT domain ACT_4 PF13291.6 CDK98428.1 - 5e-08 33.4 0.0 0.00052 20.6 0.0 2.3 2 0 0 2 2 2 2 ACT domain Phytase-like PF13449.6 CDK98429.1 - 2.6e-30 106.4 0.0 3.7e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Esterase-like activity of phytase HTH_Crp_2 PF13545.6 CDK98430.1 - 7.8e-16 57.8 0.8 1e-15 57.5 0.1 1.6 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain cNMP_binding PF00027.29 CDK98430.1 - 7e-13 48.5 0.0 2.5e-12 46.7 0.0 1.8 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Crp PF00325.20 CDK98430.1 - 1.1e-05 24.9 0.0 2.3e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, crp family MarR_2 PF12802.7 CDK98430.1 - 0.02 14.8 0.1 0.046 13.6 0.1 1.6 1 0 0 1 1 1 0 MarR family Pirin_C_2 PF17954.1 CDK98430.1 - 0.027 14.6 0.0 10 6.3 0.0 2.3 2 0 0 2 2 2 0 Quercetinase C-terminal cupin domain MarR PF01047.22 CDK98430.1 - 0.068 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 MarR family RepL PF05732.11 CDK98430.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) DUF2892 PF11127.8 CDK98431.1 - 5.8e-25 87.1 3.4 6.3e-25 87.0 3.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2892) SQS_PSY PF00494.19 CDK98432.1 - 3.2e-46 158.0 5.4 3.7e-46 157.7 5.4 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase SQS_PSY PF00494.19 CDK98433.1 - 1.8e-48 165.3 6.6 2e-48 165.2 6.6 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase SQS_PSY PF00494.19 CDK98434.1 - 4.3e-56 190.3 3.1 4.9e-56 190.1 3.1 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase Amino_oxidase PF01593.24 CDK98435.1 - 3.3e-25 89.3 0.2 1.2e-10 41.3 0.1 3.1 2 1 0 3 3 3 3 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDK98435.1 - 4.1e-13 49.4 0.6 4.1e-13 49.4 0.6 2.0 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CDK98435.1 - 8.1e-06 25.2 1.6 1.2e-05 24.6 1.6 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 CDK98435.1 - 1e-05 25.1 0.7 1.6e-05 24.5 0.7 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 CDK98435.1 - 1.3e-05 24.9 4.3 0.00023 20.9 4.3 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDK98435.1 - 1.8e-05 24.1 0.2 0.0001 21.7 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDK98435.1 - 3.1e-05 23.3 3.1 5.1e-05 22.5 3.1 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CDK98435.1 - 0.00095 18.0 0.7 0.0017 17.2 0.7 1.4 1 0 0 1 1 1 1 HI0933-like protein 3HCDH_N PF02737.18 CDK98435.1 - 0.0033 17.3 0.1 0.005 16.8 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MCRA PF06100.11 CDK98435.1 - 0.018 13.9 0.0 0.024 13.4 0.0 1.1 1 0 0 1 1 1 0 MCRA family AlaDh_PNT_C PF01262.21 CDK98435.1 - 0.052 12.8 0.1 0.081 12.2 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CDK98435.1 - 0.074 13.6 0.1 0.14 12.8 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDK98435.1 - 0.11 11.5 0.3 0.18 10.8 0.3 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 CDK98435.1 - 0.25 10.5 0.4 0.4 9.9 0.0 1.5 2 0 0 2 2 2 0 Thi4 family FAD_binding_3 PF01494.19 CDK98435.1 - 0.36 10.0 2.4 0.22 10.7 0.6 1.5 2 0 0 2 2 2 0 FAD binding domain Sod_Fe_C PF02777.18 CDK98436.1 - 3.4e-37 126.7 3.1 3.4e-37 126.7 0.3 2.2 2 1 0 3 3 3 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CDK98436.1 - 2.7e-34 117.5 1.4 4.7e-34 116.7 1.4 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain OmpA PF00691.20 CDK98437.1 - 1.4e-20 73.4 0.1 2.1e-20 72.9 0.1 1.2 1 0 0 1 1 1 1 OmpA family LPAM_1 PF08139.12 CDK98437.1 - 0.0098 16.3 2.3 0.018 15.5 2.3 1.5 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site COX7a PF02238.15 CDK98437.1 - 0.17 12.3 0.2 0.5 10.8 0.0 1.8 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII Sulf_transp PF04143.14 CDK98438.1 - 0.0042 16.7 12.6 0.0042 16.7 12.6 2.5 2 1 0 2 2 2 1 Sulphur transport DUF3325 PF11804.8 CDK98438.1 - 0.025 14.7 3.5 0.025 14.7 3.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3325) IncD PF17628.2 CDK98438.1 - 9.1 6.1 7.2 3.7 7.3 1.5 2.1 1 1 1 2 2 2 0 Inclusion membrane protein D Sulf_transp PF04143.14 CDK98439.1 - 0.00062 19.4 25.8 0.0022 17.6 25.8 1.9 1 1 0 1 1 1 1 Sulphur transport DUF2964 PF11177.8 CDK98439.1 - 5.7 7.2 8.8 5.1 7.4 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2964) Radical_SAM PF04055.21 CDK98440.1 - 8.5e-30 104.3 0.0 5.5e-28 98.4 0.0 2.6 2 0 0 2 2 2 1 Radical SAM superfamily TRAM_2 PF18693.1 CDK98440.1 - 7.4e-22 77.3 2.1 1.7e-21 76.1 2.1 1.7 1 0 0 1 1 1 1 TRAM domain UPF0004 PF00919.20 CDK98440.1 - 4.3e-15 55.6 0.0 9.9e-15 54.4 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 CDK98440.1 - 0.021 14.8 0.0 0.11 12.5 0.1 2.2 2 1 0 2 2 2 0 TRAM domain Thioredoxin_6 PF13848.6 CDK98440.1 - 0.047 13.6 0.0 0.075 12.9 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain CLP1_P PF16575.5 CDK98440.1 - 0.049 13.4 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Response_reg PF00072.24 CDK98441.1 - 4e-20 72.1 0.0 4.5e-20 71.9 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain MASE3 PF17159.4 CDK98442.1 - 2.3e-62 210.6 7.9 3.9e-62 209.8 7.9 1.4 1 0 0 1 1 1 1 Membrane-associated sensor domain HATPase_c PF02518.26 CDK98442.1 - 1e-23 84.0 0.0 2.3e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK98442.1 - 1.2e-22 80.2 0.0 2.4e-22 79.2 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CDK98442.1 - 1.1e-19 70.2 0.2 1.1e-19 70.2 0.2 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CDK98442.1 - 0.082 12.8 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 GHKL domain MerC PF03203.14 CDK98442.1 - 1.5 9.3 22.3 1.1e+02 3.3 22.3 2.8 1 1 0 1 1 1 0 MerC mercury resistance protein MIG-14_Wnt-bd PF06664.12 CDK98442.1 - 1.6 7.9 5.3 0.33 10.1 1.6 1.6 2 0 0 2 2 2 0 Wnt-binding factor required for Wnt secretion Matrilin_ccoil PF10393.9 CDK98443.1 - 2e-08 33.9 5.8 2.6 8.0 0.0 7.4 8 0 0 8 8 7 2 Trimeric coiled-coil oligomerisation domain of matrilin Dynamitin PF04912.14 CDK98443.1 - 3.8e-05 23.2 4.0 0.32 10.3 3.1 3.6 1 1 0 2 2 2 2 Dynamitin DUF1664 PF07889.12 CDK98443.1 - 4.9e-05 23.4 3.4 0.034 14.2 0.4 3.6 3 1 0 3 3 3 1 Protein of unknown function (DUF1664) TBCC_N PF16752.5 CDK98443.1 - 0.00015 22.2 2.4 1.4 9.4 0.3 4.2 1 1 1 4 4 4 1 Tubulin-specific chaperone C N-terminal domain DUF2730 PF10805.8 CDK98443.1 - 0.00077 19.5 7.8 0.02 14.9 0.5 4.0 2 2 2 4 4 4 1 Protein of unknown function (DUF2730) Spc7 PF08317.11 CDK98443.1 - 0.0014 17.6 3.6 0.032 13.1 0.5 2.5 1 1 1 2 2 2 1 Spc7 kinetochore protein Fib_alpha PF08702.10 CDK98443.1 - 0.0019 18.4 1.5 0.95 9.6 0.2 3.1 1 1 2 3 3 3 2 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 CDK98443.1 - 0.002 18.5 9.1 1.1 9.8 1.7 5.0 3 2 2 5 5 4 1 Nucleopolyhedrovirus P10 protein LUC7 PF03194.15 CDK98443.1 - 0.0025 17.5 1.1 0.073 12.7 0.0 2.2 1 1 1 2 2 2 1 LUC7 N_terminus SKA2 PF16740.5 CDK98443.1 - 0.0033 17.2 4.3 0.47 10.3 0.4 4.4 2 2 3 5 5 5 1 Spindle and kinetochore-associated protein 2 Abi_C PF14355.6 CDK98443.1 - 0.0043 17.1 0.1 0.024 14.7 0.1 2.3 2 0 0 2 2 2 1 Abortive infection C-terminus DELLA PF12041.8 CDK98443.1 - 0.0047 16.8 6.0 2.4 8.1 0.1 4.5 4 2 1 5 5 4 1 Transcriptional regulator DELLA protein N terminal Nup54 PF13874.6 CDK98443.1 - 0.0074 16.4 1.7 0.28 11.3 0.0 3.1 1 1 1 3 3 3 1 Nucleoporin complex subunit 54 KxDL PF10241.9 CDK98443.1 - 0.0076 16.5 4.0 1.5 9.1 0.0 4.3 3 2 1 5 5 5 1 Uncharacterized conserved protein DUF16 PF01519.16 CDK98443.1 - 0.0089 16.5 4.3 0.16 12.4 0.3 3.9 2 2 3 5 5 3 1 Protein of unknown function DUF16 Collagen_mid PF15984.5 CDK98443.1 - 0.0096 15.7 0.0 0.26 11.0 0.0 2.4 1 1 1 2 2 2 1 Bacterial collagen, middle region Baculo_PEP_C PF04513.12 CDK98443.1 - 0.017 15.2 7.5 3.9 7.5 0.2 4.0 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0184 PF03670.13 CDK98443.1 - 0.028 14.8 3.2 20 5.7 0.1 4.0 2 2 2 4 4 4 0 Uncharacterised protein family (UPF0184) Cep3 PF16846.5 CDK98443.1 - 0.036 12.5 0.0 0.064 11.7 0.0 1.5 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B DUF3829 PF12889.7 CDK98443.1 - 0.043 13.3 0.3 2.1 7.8 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3829) Phage_GPO PF05929.11 CDK98443.1 - 0.083 12.5 3.8 0.58 9.7 0.1 2.8 2 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase PI3K_P85_iSH2 PF16454.5 CDK98443.1 - 0.086 12.4 0.3 1.4 8.5 0.1 2.6 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4088 PF13317.6 CDK98443.1 - 0.094 12.3 1.7 8.2 5.9 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4088) HMMR_N PF15905.5 CDK98443.1 - 0.15 11.5 2.9 1.6 8.1 0.4 2.8 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DUF2120 PF09893.9 CDK98443.1 - 0.15 12.2 1.3 0.56 10.3 0.4 2.3 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) Prominin PF05478.11 CDK98443.1 - 0.16 9.9 0.2 0.34 8.8 0.1 1.6 2 0 0 2 2 2 0 Prominin DUF677 PF05055.12 CDK98443.1 - 0.18 10.7 1.3 1.8 7.4 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF677) MerR-DNA-bind PF09278.11 CDK98443.1 - 0.19 12.3 8.2 5.7 7.6 0.0 4.5 3 2 1 4 4 4 0 MerR, DNA binding DUF4795 PF16043.5 CDK98443.1 - 0.2 11.2 4.7 0.4 10.3 0.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Laminin_II PF06009.12 CDK98443.1 - 0.21 11.6 7.2 0.37 10.8 1.7 3.2 3 1 0 3 3 3 0 Laminin Domain II SLS PF14611.6 CDK98443.1 - 0.22 11.3 2.6 0.25 11.2 0.6 2.0 2 1 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator Transcrip_act PF04949.13 CDK98443.1 - 0.32 10.9 3.6 0.36 10.7 1.1 2.3 3 0 0 3 3 2 0 Transcriptional activator BLOC1_2 PF10046.9 CDK98443.1 - 0.36 11.1 8.6 1.2 9.5 0.0 4.6 5 2 0 5 5 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin_1 PF12718.7 CDK98443.1 - 0.37 10.9 4.0 0.88 9.7 0.4 2.8 3 0 0 3 3 3 0 Tropomyosin like EzrA PF06160.12 CDK98443.1 - 0.47 8.6 4.2 3.2 5.8 4.4 2.2 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA XhlA PF10779.9 CDK98443.1 - 0.61 10.3 10.8 4.5 7.5 0.6 4.9 3 1 3 6 6 5 0 Haemolysin XhlA DUF5304 PF17230.2 CDK98443.1 - 0.89 9.8 6.6 1.4 9.2 0.1 3.4 3 1 0 3 3 3 0 Family of unknown function (DUF5304) HSBP1 PF06825.12 CDK98443.1 - 1.2 9.1 9.6 7.9 6.4 0.0 5.6 7 0 0 7 7 7 0 Heat shock factor binding protein 1 CorA PF01544.18 CDK98443.1 - 1.2 8.4 5.4 5.2 6.3 2.1 3.0 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein DNA_repr_REX1B PF14966.6 CDK98443.1 - 1.5 9.5 5.0 26 5.6 0.1 4.2 3 2 2 5 5 5 0 DNA repair REX1-B HrpB7 PF09486.10 CDK98443.1 - 3.5 8.0 15.9 2.4 8.5 0.5 4.3 3 1 1 4 4 4 0 Bacterial type III secretion protein (HrpB7) Response_reg PF00072.24 CDK98444.1 - 7.6e-33 113.0 0.1 1.7e-22 79.7 0.0 2.4 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 CDK98444.1 - 5.8e-30 104.1 0.0 1.6e-29 102.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98444.1 - 3e-18 65.6 2.0 5.8e-18 64.7 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain YukD PF08817.10 CDK98444.1 - 0.012 16.3 0.1 0.037 14.7 0.1 1.8 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD dCache_1 PF02743.18 CDK98444.1 - 0.014 15.2 0.9 0.017 14.9 0.1 1.5 2 0 0 2 2 2 0 Cache domain HATPase_c_3 PF13589.6 CDK98444.1 - 0.043 13.7 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cache_3-Cache_2 PF17201.4 CDK98444.1 - 0.12 11.6 0.0 0.27 10.5 0.0 1.5 1 0 0 1 1 1 0 Cache 3/Cache 2 fusion domain Response_reg PF00072.24 CDK98445.1 - 2.3e-25 88.9 0.7 3.6e-25 88.3 0.1 1.6 2 0 0 2 2 2 1 Response regulator receiver domain HD PF01966.22 CDK98445.1 - 1e-17 64.5 0.1 2.2e-17 63.4 0.1 1.6 1 0 0 1 1 1 1 HD domain HD_5 PF13487.6 CDK98445.1 - 1.3e-14 54.2 0.2 2.8e-14 53.1 0.2 1.6 1 0 0 1 1 1 1 HD domain Response_reg PF00072.24 CDK98446.1 - 4.5e-44 149.2 1.1 1.3e-26 92.9 0.3 2.6 2 0 0 2 2 2 2 Response regulator receiver domain PAS_3 PF08447.12 CDK98446.1 - 2.7e-40 136.5 0.2 1.5e-23 82.9 0.0 2.7 2 0 0 2 2 2 2 PAS fold HATPase_c PF02518.26 CDK98446.1 - 8.1e-30 103.6 0.4 1.7e-29 102.6 0.4 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 CDK98446.1 - 7.7e-24 83.9 0.0 2.3e-15 56.7 0.0 2.9 3 0 0 3 3 3 2 PAS domain HisKA PF00512.25 CDK98446.1 - 1.1e-18 67.0 0.1 5.8e-18 64.7 0.1 2.4 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CDK98446.1 - 1.2e-16 60.7 0.1 2.5e-10 40.3 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 CDK98446.1 - 1.6e-15 57.3 0.9 1.8e-08 34.6 0.0 3.2 3 0 0 3 3 3 2 PAS fold Hpt PF01627.23 CDK98446.1 - 3.8e-12 46.3 1.6 8.6e-12 45.2 0.2 2.5 2 0 0 2 2 2 1 Hpt domain PAS_8 PF13188.7 CDK98446.1 - 0.00014 21.8 0.0 0.002 18.1 0.0 2.7 2 0 0 2 2 2 1 PAS domain FIST PF08495.10 CDK98447.1 - 1.5e-34 119.5 1.9 3e-34 118.5 0.5 1.9 2 0 0 2 2 2 1 FIST N domain FIST_C PF10442.9 CDK98447.1 - 1.4e-33 115.6 0.1 3.5e-30 104.6 0.1 2.3 2 0 0 2 2 2 2 FIST C domain HATPase_c_2 PF13581.6 CDK98448.1 - 1.3e-12 47.7 0.0 2.5e-12 46.8 0.0 1.4 1 1 0 1 1 1 1 Histidine kinase-like ATPase domain STAS_2 PF13466.6 CDK98449.1 - 4e-26 91.2 0.6 3.5e-12 46.5 0.1 2.2 2 0 0 2 2 2 2 STAS domain STAS PF01740.21 CDK98449.1 - 2.8e-19 68.9 0.0 9.7e-10 38.1 0.0 2.1 2 0 0 2 2 2 2 STAS domain SpoIIE PF07228.12 CDK98450.1 - 6.7e-33 114.2 0.0 1e-32 113.6 0.0 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Response_reg PF00072.24 CDK98450.1 - 1.5e-17 63.8 0.1 2.4e-17 63.1 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain ThiG PF05690.14 CDK98450.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG Response_reg PF00072.24 CDK98451.1 - 1.7e-19 70.0 0.1 2e-19 69.8 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain DUF3088 PF11287.8 CDK98451.1 - 0.11 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3088) PAS_9 PF13426.7 CDK98452.1 - 4.1e-19 68.8 0.0 8.3e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 PAS domain HATPase_c PF02518.26 CDK98452.1 - 4.2e-18 65.9 0.1 1.2e-17 64.4 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 CDK98452.1 - 2.5e-09 37.2 0.0 4.8e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 CDK98452.1 - 2.6e-08 34.1 0.0 5.4e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDK98452.1 - 6.9e-07 29.5 0.6 3.6e-06 27.2 0.1 2.4 2 0 0 2 2 2 1 PAS fold dCache_1 PF02743.18 CDK98452.1 - 9.9e-07 28.8 0.0 3.9e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 Cache domain PAS_8 PF13188.7 CDK98452.1 - 5.4e-06 26.3 0.0 1.9e-05 24.6 0.0 2.0 1 0 0 1 1 1 1 PAS domain Wzy_C_2 PF11846.8 CDK98452.1 - 0.025 14.5 2.0 0.036 14.0 0.2 2.1 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal DUF4325 PF14213.6 CDK98452.1 - 0.032 13.9 0.3 0.059 13.1 0.3 1.4 1 0 0 1 1 1 0 STAS-like domain of unknown function (DUF4325) SBP_bac_3 PF00497.20 CDK98453.1 - 2e-44 151.7 0.0 2.4e-44 151.4 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 CDK98453.1 - 1.5e-05 25.2 0.0 0.00022 21.4 0.0 2.4 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site LigB PF02900.18 CDK98454.1 - 1.1e-38 132.8 0.0 1.4e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase DoxX PF07681.12 CDK98455.1 - 4e-17 62.6 11.3 7.3e-17 61.7 11.3 1.4 1 0 0 1 1 1 1 DoxX DoxD PF04173.13 CDK98455.1 - 0.0059 16.5 1.0 0.0082 16.1 1.0 1.2 1 0 0 1 1 1 1 TQO small subunit DoxD DoxX_2 PF13564.6 CDK98455.1 - 0.0081 16.2 12.0 0.015 15.4 12.0 1.5 1 0 0 1 1 1 1 DoxX-like family LysR_substrate PF03466.20 CDK98456.1 - 3.9e-49 166.9 2.5 5.4e-49 166.4 2.5 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDK98456.1 - 1.7e-17 63.1 4.9 3e-17 62.3 4.9 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR_2 PF12802.7 CDK98456.1 - 0.025 14.4 1.4 0.089 12.7 0.2 2.4 2 0 0 2 2 2 0 MarR family DUF4570 PF15134.6 CDK98456.1 - 0.31 11.1 1.1 0.48 10.5 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) YlqD PF11068.8 CDK98456.1 - 0.66 10.4 1.7 1 9.8 1.7 1.2 1 0 0 1 1 1 0 YlqD protein ketoacyl-synt PF00109.26 CDK98457.1 - 8.2e-38 130.4 3.0 3.1e-36 125.3 1.6 2.0 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CDK98457.1 - 6.6e-26 90.6 0.0 1.2e-25 89.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CDK98457.1 - 1.2e-05 24.8 0.2 3.3e-05 23.4 0.1 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CDK98457.1 - 0.13 12.2 0.8 15 5.5 0.1 3.1 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III adh_short_C2 PF13561.6 CDK98458.1 - 2.9e-54 184.1 3.9 3.3e-54 183.9 3.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDK98458.1 - 4.6e-50 169.8 0.4 5.4e-50 169.6 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDK98458.1 - 3.1e-19 69.6 0.4 5.2e-19 68.9 0.4 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CDK98458.1 - 0.00081 18.9 0.1 0.00095 18.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family FabA PF07977.13 CDK98459.1 - 0.00033 20.3 0.0 0.00076 19.1 0.0 1.6 1 1 0 1 1 1 1 FabA-like domain Ketoacyl-synt_C PF02801.22 CDK98460.1 - 9e-28 96.7 0.1 2.3e-27 95.4 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 CDK98460.1 - 7.8e-27 94.4 3.9 2.2e-26 93.0 1.5 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Thiolase_N PF00108.23 CDK98460.1 - 0.00019 20.9 1.1 0.022 14.1 0.3 2.2 2 0 0 2 2 2 2 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CDK98460.1 - 0.71 9.8 3.9 1.4 8.8 0.7 3.0 4 0 0 4 4 4 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF3261 PF11659.8 CDK98461.1 - 2.2e-28 98.8 0.0 2.7e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3261) LolB PF03550.14 CDK98461.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein LolB MMPL PF03176.15 CDK98462.1 - 0.0021 17.0 12.6 0.0021 17.0 12.6 3.5 2 1 0 2 2 2 1 MMPL family LolA PF03548.15 CDK98463.1 - 0.055 13.2 0.0 0.13 12.0 0.0 1.5 1 1 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA 4HBT_2 PF13279.6 CDK98464.1 - 6.9e-11 42.7 0.0 7.9e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 CDK98464.1 - 1.2e-10 41.6 0.0 3.5e-10 40.1 0.0 1.7 1 1 1 2 2 2 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 CDK98464.1 - 1.9e-05 24.1 0.0 2.8e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Acyl-ACP thioesterase Glycos_transf_2 PF00535.26 CDK98465.1 - 2.5e-15 56.7 0.0 5.8e-15 55.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Lip_A_acyltrans PF03279.13 CDK98465.1 - 2.3e-10 40.1 0.0 3.7e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial lipid A biosynthesis acyltransferase FabA PF07977.13 CDK98466.1 - 2.6e-06 27.1 0.0 4.7e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 FabA-like domain AMP-binding PF00501.28 CDK98467.1 - 1.5e-17 63.3 1.9 3.1e-11 42.5 0.0 3.1 2 1 1 3 3 3 3 AMP-binding enzyme AMP-binding_C PF13193.6 CDK98467.1 - 1.8e-07 32.1 0.0 6e-07 30.4 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Rubella_E1 PF05748.11 CDK98468.1 - 0.22 10.3 2.5 1.4 7.7 0.4 2.2 1 1 1 2 2 2 0 Rubella membrane glycoprotein E1 PP-binding PF00550.25 CDK98469.1 - 8.3e-11 42.1 0.1 9.5e-11 41.9 0.1 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CDK98469.1 - 0.015 15.5 0.2 0.017 15.3 0.2 1.1 1 0 0 1 1 1 0 Acyl-carrier DUF4224 PF13986.6 CDK98469.1 - 0.15 12.0 0.4 0.34 10.8 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4224) PP-binding PF00550.25 CDK98470.1 - 4.7e-10 39.7 0.5 6.5e-10 39.2 0.5 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site Acyltransferase PF01553.21 CDK98471.1 - 7.8e-12 45.0 0.0 1.3e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Ketoacyl-synt_2 PF13723.6 CDK98472.1 - 1.8e-56 191.3 0.0 2e-56 191.1 0.0 1.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Cytochrome_CBB3 PF13442.6 CDK98473.1 - 0.00012 22.3 0.0 0.00016 21.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDK98473.1 - 0.00048 21.2 0.1 0.0011 20.1 0.1 1.7 1 1 0 1 1 1 1 Cytochrome c FCSD-flav_bind PF09242.11 CDK98474.1 - 2.2e-31 108.0 1.1 3e-30 104.4 0.1 2.9 2 1 2 4 4 4 1 Flavocytochrome c sulphide dehydrogenase, flavin-binding Pyr_redox_2 PF07992.14 CDK98474.1 - 1.1e-14 54.4 1.2 2.3e-12 46.8 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDK98474.1 - 0.00029 20.5 0.2 0.00091 18.9 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDK98474.1 - 0.00058 19.9 0.1 0.71 9.9 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox PF00070.27 CDK98474.1 - 0.0006 20.3 0.1 0.0018 18.8 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDK98474.1 - 0.00082 19.6 0.1 0.0037 17.5 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Mqo PF06039.15 CDK98474.1 - 0.0099 14.5 0.0 0.016 13.8 0.0 1.3 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) Trp_halogenase PF04820.14 CDK98474.1 - 0.023 13.6 0.0 0.037 12.9 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 CDK98474.1 - 0.023 13.9 0.3 0.061 12.6 0.0 1.7 2 0 0 2 2 2 0 Thi4 family K_oxygenase PF13434.6 CDK98474.1 - 0.043 13.0 0.0 0.075 12.2 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 CDK98474.1 - 0.062 12.4 0.0 0.12 11.5 0.0 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A SBP_bac_11 PF13531.6 CDK98475.1 - 7.4e-45 153.5 1.6 1.1e-44 152.9 0.0 1.8 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CDK98475.1 - 7.8e-17 62.2 3.6 1.1e-16 61.8 3.6 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 CDK98475.1 - 1e-08 35.3 0.7 1.4e-08 34.9 0.7 1.3 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 CDK98475.1 - 1.2e-06 28.2 0.3 6.4e-06 25.8 0.1 1.8 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein PBP_like PF12727.7 CDK98475.1 - 0.00088 18.4 0.0 0.0022 17.1 0.0 1.6 1 0 0 1 1 1 1 PBP superfamily domain BPD_transp_1 PF00528.22 CDK98476.1 - 5.6e-24 84.9 17.4 5.6e-24 84.9 17.4 2.0 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 CDK98477.1 - 9.8e-11 41.7 10.5 9.8e-11 41.7 10.5 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2273 PF10031.9 CDK98477.1 - 0.064 13.3 0.2 0.064 13.3 0.2 3.1 3 0 0 3 3 3 0 Small integral membrane protein (DUF2273) ABC_tran PF00005.27 CDK98478.1 - 4.9e-35 121.0 0.0 7e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98478.1 - 1.7e-09 38.0 0.3 0.00026 20.9 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK98478.1 - 1.8e-08 34.1 0.0 4.3e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain CysA_C_terminal PF17850.1 CDK98478.1 - 6.3e-08 33.1 0.2 6.3e-08 33.1 0.2 2.5 3 0 0 3 3 2 1 CysA C-terminal regulatory domain TOBE_3 PF12857.7 CDK98478.1 - 3.2e-06 27.0 0.7 8.1e-06 25.7 0.7 1.7 1 0 0 1 1 1 1 TOBE-like domain TOBE PF03459.17 CDK98478.1 - 3.6e-05 24.0 1.2 9.6e-05 22.6 0.5 2.1 2 0 0 2 2 1 1 TOBE domain TOBE_2 PF08402.10 CDK98478.1 - 9.2e-05 22.5 2.8 0.00023 21.2 1.0 2.6 3 0 0 3 3 3 1 TOBE domain AAA_22 PF13401.6 CDK98478.1 - 0.00067 20.0 0.1 0.0032 17.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDK98478.1 - 0.0012 19.2 1.3 0.0027 18.1 0.9 1.8 1 1 1 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CDK98478.1 - 0.0014 18.4 0.0 0.003 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDK98478.1 - 0.003 17.5 0.0 0.0054 16.7 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CDK98478.1 - 0.0038 16.9 0.1 0.0091 15.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDK98478.1 - 0.0041 17.7 0.1 0.0067 16.9 0.1 1.2 1 0 0 1 1 1 1 AAA domain SbcCD_C PF13558.6 CDK98478.1 - 0.0057 16.9 0.1 0.039 14.2 0.1 2.1 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit NTPase_1 PF03266.15 CDK98478.1 - 0.0069 16.3 0.0 0.038 13.9 0.0 1.9 2 0 0 2 2 2 1 NTPase AAA_33 PF13671.6 CDK98478.1 - 0.0078 16.4 0.1 0.018 15.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 CDK98478.1 - 0.017 13.9 0.6 0.44 9.3 0.0 2.7 2 1 0 2 2 2 0 Predicted ATPase of the ABC class AAA PF00004.29 CDK98478.1 - 0.018 15.4 0.0 0.13 12.7 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDK98478.1 - 0.02 15.4 0.1 0.034 14.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDK98478.1 - 0.025 14.3 0.0 0.25 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDK98478.1 - 0.025 14.8 0.1 0.05 13.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDK98478.1 - 0.029 13.7 0.1 7 5.9 0.0 2.2 2 0 0 2 2 2 0 KaiC NACHT PF05729.12 CDK98478.1 - 0.034 14.1 1.1 0.057 13.3 0.2 1.7 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 CDK98478.1 - 0.041 13.4 0.4 0.29 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 CDK98478.1 - 0.055 13.4 0.0 0.085 12.8 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain DLIC PF05783.11 CDK98478.1 - 0.12 11.2 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_5 PF07728.14 CDK98478.1 - 0.13 12.3 0.2 0.52 10.3 0.1 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 CDK98478.1 - 0.14 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 CDK98478.1 - 0.15 11.5 0.1 4 6.8 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein cobW PF02492.19 CDK98478.1 - 0.16 11.6 0.2 0.27 10.8 0.2 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain HATPase_c PF02518.26 CDK98479.1 - 6.1e-30 104.0 0.0 1e-29 103.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK98479.1 - 3.8e-26 91.5 0.2 3.3e-25 88.4 0.0 2.5 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 CDK98479.1 - 6.8e-16 58.1 0.9 1.8e-15 56.7 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.23 CDK98479.1 - 4.2e-08 33.4 6.2 5.7e-08 32.9 4.2 2.3 2 0 0 2 2 2 1 Hpt domain HATPase_c_3 PF13589.6 CDK98479.1 - 0.067 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK98480.1 - 8.2e-22 77.5 0.0 1.2e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK98480.1 - 5.3e-20 71.3 0.1 1.5e-18 66.6 0.0 2.4 3 0 0 3 3 3 1 Transcriptional regulatory protein, C terminal LPAM_1 PF08139.12 CDK98481.1 - 0.055 14.0 4.9 0.055 14.0 4.9 1.5 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site LPAM_2 PF13627.6 CDK98481.1 - 8.7 6.3 7.7 15 5.6 7.7 1.4 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site TauE PF01925.19 CDK98482.1 - 6.4e-45 153.6 47.7 8e-45 153.3 47.7 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE SRAP PF02586.14 CDK98483.1 - 3.2e-19 69.3 0.0 4.1e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) DDE_3 PF13358.6 CDK98484.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK98484.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDK98485.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK98485.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK98485.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK98485.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK98485.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK98485.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain FtsJ PF01728.19 CDK98486.1 - 1.9e-25 90.0 0.0 2.4e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase S4 PF01479.25 CDK98486.1 - 4.7e-10 39.0 0.3 1.3e-09 37.6 0.3 1.8 1 0 0 1 1 1 1 S4 domain BRK PF07533.16 CDK98486.1 - 0.00039 20.0 0.0 0.53 10.0 0.0 2.4 2 0 0 2 2 2 2 BRK domain Methyltransf_11 PF08241.12 CDK98486.1 - 0.0038 17.9 0.0 0.0063 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK98486.1 - 0.0075 16.9 0.0 0.013 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain S4_2 PF13275.6 CDK98486.1 - 0.11 12.4 1.1 0.17 11.8 0.4 1.7 2 0 0 2 2 2 0 S4 domain Hist_deacetyl PF00850.19 CDK98487.1 - 1e-83 281.4 0.7 1.3e-83 281.1 0.7 1.1 1 0 0 1 1 1 1 Histone deacetylase domain ROK PF00480.20 CDK98488.1 - 2.2e-71 240.8 0.0 2.4e-71 240.6 0.0 1.0 1 0 0 1 1 1 1 ROK family Glucokinase PF02685.16 CDK98488.1 - 1.3e-06 27.7 0.3 4.4e-06 25.9 0.3 1.8 1 1 0 1 1 1 1 Glucokinase BcrAD_BadFG PF01869.20 CDK98488.1 - 0.0014 18.1 0.3 0.13 11.7 0.4 2.2 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family Hydant_A_N PF05378.13 CDK98488.1 - 0.014 15.1 0.2 0.021 14.6 0.2 1.2 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region Lactamase_B PF00753.27 CDK98489.1 - 1.4e-27 97.0 1.0 2.5e-27 96.2 1.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily CcmB PF03379.13 CDK98489.1 - 0.014 14.9 0.1 0.023 14.2 0.1 1.2 1 0 0 1 1 1 0 CcmB protein Lactamase_B_2 PF12706.7 CDK98489.1 - 0.035 13.6 0.1 0.073 12.6 0.1 1.8 1 1 0 1 1 1 0 Beta-lactamase superfamily domain BLACT_WH PF17778.1 CDK98489.1 - 0.048 13.7 0.0 0.19 11.7 0.0 1.9 2 0 0 2 2 2 0 Beta-lactamase associated winged helix domain Peripla_BP_4 PF13407.6 CDK98490.1 - 1.4e-47 162.4 1.0 1.7e-47 162.2 1.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 CDK98490.1 - 6e-14 52.1 0.2 1.3e-13 51.0 0.2 1.4 1 1 1 2 2 2 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 CDK98490.1 - 9.9e-07 29.2 0.9 0.00016 22.1 0.2 2.2 2 0 0 2 2 2 2 Periplasmic binding protein-like domain HATPase_c PF02518.26 CDK98491.1 - 2.2e-26 92.6 0.0 5e-26 91.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 CDK98491.1 - 1.1e-23 83.3 0.4 1.2e-22 80.0 0.1 2.6 2 0 0 2 2 2 1 PAS fold HisKA PF00512.25 CDK98491.1 - 2.3e-10 40.3 0.7 7e-10 38.8 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CDK98491.1 - 0.0018 18.2 0.0 0.0052 16.7 0.0 1.7 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 CDK98491.1 - 0.0021 17.9 0.0 0.0066 16.3 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 CDK98491.1 - 0.012 16.0 0.1 0.034 14.5 0.1 1.9 1 0 0 1 1 1 0 HAMP domain PAS PF00989.25 CDK98491.1 - 0.023 14.7 0.2 0.44 10.6 0.0 2.9 3 1 0 3 3 3 0 PAS fold PAS_11 PF14598.6 CDK98491.1 - 0.032 14.3 0.0 0.07 13.3 0.0 1.5 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 CDK98491.1 - 0.099 12.9 0.1 0.52 10.6 0.0 2.2 2 0 0 2 2 2 0 PAS fold HTH_5 PF01022.20 CDK98492.1 - 6.1e-14 51.6 2.1 9.9e-14 50.9 2.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 CDK98492.1 - 2.4e-10 40.3 1.9 3.5e-10 39.8 1.9 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HxlR PF01638.17 CDK98492.1 - 3.9e-07 29.8 0.2 5.7e-07 29.3 0.2 1.3 1 1 0 1 1 1 1 HxlR-like helix-turn-helix MarR_2 PF12802.7 CDK98492.1 - 5e-07 29.5 0.9 7.7e-07 28.9 0.9 1.4 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 CDK98492.1 - 0.0022 17.5 0.3 0.0038 16.7 0.3 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 CDK98492.1 - 0.0036 17.1 0.0 0.0057 16.5 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 CDK98492.1 - 0.0037 17.2 0.2 0.0068 16.3 0.2 1.5 1 0 0 1 1 1 1 MarR family TFIIE_alpha PF02002.17 CDK98492.1 - 0.0048 16.7 0.1 0.0069 16.2 0.1 1.3 1 1 0 1 1 1 1 TFIIE alpha subunit Rrf2 PF02082.20 CDK98492.1 - 0.005 17.1 0.3 0.0071 16.7 0.3 1.3 1 0 0 1 1 1 1 Transcriptional regulator PaaX PF07848.12 CDK98492.1 - 0.011 15.9 0.8 0.25 11.6 0.3 2.2 1 1 1 2 2 2 0 PaaX-like protein HTH_Crp_2 PF13545.6 CDK98492.1 - 0.013 15.4 1.4 0.021 14.8 1.4 1.5 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_28 PF13518.6 CDK98492.1 - 0.015 15.4 0.2 0.026 14.6 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_1 PF00126.27 CDK98492.1 - 0.018 15.0 0.1 0.038 13.9 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family TFA2_Winged_2 PF18121.1 CDK98492.1 - 0.15 11.7 0.1 0.2 11.3 0.1 1.4 1 1 0 1 1 1 0 TFA2 Winged helix domain 2 DXP_synthase_N PF13292.6 CDK98493.1 - 7e-117 389.5 0.0 1.2e-116 388.7 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.24 CDK98493.1 - 9.7e-37 126.4 0.0 1.8e-36 125.5 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDK98493.1 - 3.2e-30 104.5 0.0 7e-30 103.5 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 CDK98493.1 - 1.2e-05 24.5 0.0 2e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_N PF00456.21 CDK98493.1 - 7e-05 21.9 0.3 0.062 12.2 0.1 3.4 4 0 0 4 4 4 2 Transketolase, thiamine diphosphate binding domain TPP_enzyme_C PF02775.21 CDK98493.1 - 0.0007 19.4 0.1 0.0037 17.1 0.3 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF3523 PF12037.8 CDK98493.1 - 0.16 11.3 0.6 0.67 9.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3523) polyprenyl_synt PF00348.17 CDK98494.1 - 2e-53 181.1 0.3 2.5e-53 180.8 0.3 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase Exonuc_VII_S PF02609.16 CDK98495.1 - 8.1e-19 67.4 0.5 9.8e-19 67.2 0.5 1.1 1 0 0 1 1 1 1 Exonuclease VII small subunit Vps53_N PF04100.12 CDK98495.1 - 0.028 13.4 0.0 0.033 13.2 0.0 1.0 1 0 0 1 1 1 0 Vps53-like, N-terminal Ribosomal_S4 PF00163.19 CDK98496.1 - 6.3e-26 91.1 1.0 9.9e-26 90.5 1.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 CDK98496.1 - 1.6e-18 66.1 0.3 2.9e-18 65.3 0.3 1.5 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 CDK98496.1 - 0.0012 18.7 0.1 0.0024 17.6 0.1 1.5 1 0 0 1 1 1 1 S4 domain Response_reg PF00072.24 CDK98497.1 - 7.1e-12 45.5 0.3 9.6e-12 45.1 0.3 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Phage_integrase PF00589.22 CDK98498.1 - 3.7e-12 46.4 3.6 1.6e-10 41.0 0.1 2.8 2 1 1 3 3 3 2 Phage integrase family Phage_int_SAM_3 PF14659.6 CDK98498.1 - 0.00068 19.8 0.0 0.0028 17.9 0.0 2.0 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Zn_Tnp_IS91 PF14319.6 CDK98502.1 - 0.035 14.1 0.7 0.41 10.7 0.9 2.4 2 0 0 2 2 2 0 Transposase zinc-binding domain DUF4136 PF13590.6 CDK98502.1 - 0.068 13.7 0.1 0.17 12.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4136) Phasin_2 PF09361.10 CDK98505.1 - 3.8e-23 81.7 13.4 4.6e-23 81.4 13.4 1.1 1 0 0 1 1 1 1 Phasin protein PHB_acc_N PF07879.11 CDK98505.1 - 0.0083 16.2 0.0 0.022 14.9 0.0 1.7 2 0 0 2 2 2 1 PHB/PHA accumulation regulator DNA-binding domain DUF5344 PF17279.2 CDK98505.1 - 0.026 15.1 0.5 0.026 15.1 0.5 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5344) T3SS_needle_F PF09392.10 CDK98505.1 - 0.041 14.1 3.5 0.081 13.1 0.5 2.5 2 1 1 3 3 3 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF TACC_C PF05010.14 CDK98505.1 - 0.088 12.6 2.6 0.086 12.6 1.7 1.4 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal HlyD_D23 PF16576.5 CDK98506.1 - 1.6e-16 60.1 2.0 2.7e-16 59.4 2.0 1.4 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK98506.1 - 3.7e-13 49.1 0.4 3.7e-13 49.1 0.4 3.4 3 0 0 3 3 3 1 Biotin-lipoyl like HlyD_3 PF13437.6 CDK98506.1 - 4.6e-10 40.2 0.6 5.2e-05 23.9 0.0 2.8 2 0 0 2 2 2 2 HlyD family secretion protein PTS_EIIA_1 PF00358.20 CDK98506.1 - 0.021 14.6 0.0 0.049 13.4 0.0 1.6 1 0 0 1 1 1 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 She9_MDM33 PF05546.11 CDK98506.1 - 0.022 14.6 1.3 0.033 14.0 1.3 1.2 1 0 0 1 1 1 0 She9 / Mdm33 family DDE_Tnp_IS1595 PF12762.7 CDK98506.1 - 0.08 13.0 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 ISXO2-like transposase domain Biotin_lipoyl PF00364.22 CDK98506.1 - 0.098 12.5 0.0 0.28 11.0 0.0 1.8 1 0 0 1 1 1 0 Biotin-requiring enzyme DUF4330 PF14221.6 CDK98506.1 - 0.11 12.7 1.9 0.24 11.6 0.5 2.3 2 2 0 2 2 2 0 Domain of unknown function (DUF4330) OEP PF02321.18 CDK98506.1 - 0.82 9.5 14.5 0.42 10.4 12.2 1.7 2 0 0 2 2 2 0 Outer membrane efflux protein DUF4337 PF14235.6 CDK98506.1 - 1.6 8.8 8.0 2.5 8.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) ACR_tran PF00873.19 CDK98507.1 - 2.3e-301 1002.2 27.9 2.6e-301 1002.0 27.9 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family SecD_SecF PF02355.16 CDK98507.1 - 3e-10 39.8 25.3 7.5e-06 25.5 12.0 2.4 2 0 0 2 2 2 2 Protein export membrane protein MMPL PF03176.15 CDK98507.1 - 5.4e-10 38.7 28.8 5.1e-08 32.2 8.9 2.7 2 0 0 2 2 2 2 MMPL family Patched PF02460.18 CDK98507.1 - 0.0017 16.5 16.3 0.0017 16.5 16.3 2.1 2 0 0 2 2 2 1 Patched family Cys_rich_KTR PF14205.6 CDK98508.1 - 0.00011 21.9 1.4 0.00013 21.7 1.4 1.1 1 0 0 1 1 1 1 Cysteine-rich KTR ADD_ATRX PF17981.1 CDK98508.1 - 0.028 14.3 2.8 0.065 13.1 2.8 1.6 1 1 0 1 1 1 0 Cysteine Rich ADD domain zf-SNAP50_C PF12251.8 CDK98508.1 - 0.14 11.8 1.6 0.15 11.7 1.6 1.0 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal zf-DNL PF05180.12 CDK98508.1 - 0.19 11.7 4.3 0.36 10.8 4.3 1.5 1 1 0 1 1 1 0 DNL zinc finger DUF5368 PF17336.2 CDK98509.1 - 1.7e-42 144.0 7.6 1.9e-42 143.9 7.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5368) HisKA_7TM PF16927.5 CDK98509.1 - 0.025 14.6 2.9 0.03 14.4 2.9 1.1 1 0 0 1 1 1 0 N-terminal 7TM region of histidine kinase DUF5518 PF17647.1 CDK98509.1 - 9.8 6.4 21.1 54 4.0 21.1 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5518) Pyr_redox_2 PF07992.14 CDK98510.1 - 1.9e-17 63.5 0.8 1.3e-14 54.2 0.6 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDK98510.1 - 4.8e-07 29.9 0.6 0.002 18.1 0.1 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 CDK98510.1 - 1.3e-05 25.0 4.0 0.0055 16.3 1.5 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDK98510.1 - 7.2e-05 22.9 0.5 0.00016 21.9 0.5 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CDK98510.1 - 0.00015 20.9 0.3 0.00029 20.0 0.1 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 CDK98510.1 - 0.0056 15.4 0.6 0.063 12.0 0.5 2.3 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox_3 PF13738.6 CDK98510.1 - 0.0068 15.7 1.1 0.26 10.5 0.4 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CDK98510.1 - 0.0071 15.7 0.8 0.013 14.8 0.8 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 CDK98510.1 - 0.012 15.2 0.1 0.02 14.5 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 CDK98510.1 - 0.021 14.1 0.1 0.038 13.2 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Pribosyltran PF00156.27 CDK98510.1 - 0.042 13.4 0.0 0.097 12.2 0.0 1.6 1 0 0 1 1 1 0 Phosphoribosyl transferase domain FAD_binding_3 PF01494.19 CDK98510.1 - 0.044 13.0 0.3 0.064 12.5 0.3 1.2 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 CDK98510.1 - 0.065 12.1 0.4 0.11 11.3 0.2 1.4 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_7 PF13241.6 CDK98510.1 - 0.074 13.5 0.1 0.17 12.4 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.27 CDK98510.1 - 0.08 13.5 0.8 0.37 11.4 0.2 2.3 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDK98510.1 - 0.093 11.8 3.6 6.1 5.8 0.0 3.0 2 1 1 3 3 3 0 Glucose inhibited division protein A GST_N PF02798.20 CDK98511.1 - 1.1e-17 64.1 0.0 1.8e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CDK98511.1 - 2.2e-17 63.2 0.0 4e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDK98511.1 - 4.9e-17 62.0 0.0 7.7e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CDK98511.1 - 7.4e-06 25.9 0.0 1.7e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CDK98511.1 - 0.011 15.9 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CDK98511.1 - 0.065 14.0 0.0 0.32 11.7 0.0 2.2 2 1 0 2 2 2 0 Glutathione S-transferase N-terminal domain FAA_hydrolase PF01557.18 CDK98512.1 - 7.6e-41 140.2 0.0 9.8e-41 139.8 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydro_N_2 PF18288.1 CDK98512.1 - 2.7e-30 104.6 0.0 4.6e-30 103.9 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal domain 2 DUF2783 PF10932.8 CDK98513.1 - 1.6e-31 107.8 0.1 1.8e-31 107.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2783) FAD_binding_3 PF01494.19 CDK98514.1 - 2.9e-59 201.1 0.0 3.5e-59 200.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CDK98514.1 - 7e-10 38.6 0.1 8.6e-09 35.0 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDK98514.1 - 2.4e-06 27.4 0.8 1.1e-05 25.2 0.4 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDK98514.1 - 0.00015 22.0 0.1 0.00033 20.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CDK98514.1 - 0.00018 20.7 0.7 0.00027 20.2 0.7 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CDK98514.1 - 0.00022 20.1 0.4 0.00039 19.2 0.4 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 CDK98514.1 - 0.00031 20.1 0.1 0.00098 18.5 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDK98514.1 - 0.00054 19.4 1.1 0.00087 18.7 1.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CDK98514.1 - 0.00069 18.8 0.3 0.00098 18.3 0.3 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 CDK98514.1 - 0.0011 19.5 0.7 0.099 13.2 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CDK98514.1 - 0.0028 16.9 0.1 0.0046 16.2 0.1 1.2 1 0 0 1 1 1 1 Thi4 family ThiF PF00899.21 CDK98514.1 - 0.011 15.2 0.2 0.018 14.4 0.2 1.2 1 0 0 1 1 1 0 ThiF family Trp_halogenase PF04820.14 CDK98514.1 - 0.022 13.6 0.0 0.031 13.1 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase AlaDh_PNT_C PF01262.21 CDK98514.1 - 0.038 13.3 0.1 0.072 12.4 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 CDK98514.1 - 0.05 13.9 0.2 0.097 12.9 0.2 1.4 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 CDK98514.1 - 0.052 13.4 0.3 0.078 12.9 0.3 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CDK98514.1 - 0.065 12.8 1.3 0.1 12.1 1.3 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Lycopene_cycl PF05834.12 CDK98514.1 - 0.11 11.5 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein ApbA PF02558.16 CDK98514.1 - 0.17 11.5 0.1 0.34 10.6 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Lactamase_B PF00753.27 CDK98515.1 - 2.5e-13 50.5 0.9 2.9e-12 47.0 0.9 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Collar PF07484.12 CDK98516.1 - 9e-24 83.2 1.6 1e-23 83.1 0.4 1.7 2 0 0 2 2 2 1 Phage Tail Collar Domain Rrf2 PF02082.20 CDK98517.1 - 2.9e-21 75.6 0.1 5.7e-21 74.7 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulator GntR PF00392.21 CDK98517.1 - 3.1e-06 26.7 0.2 7.6e-06 25.5 0.1 1.6 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_20 PF12840.7 CDK98517.1 - 8.1e-06 25.8 0.3 3.7e-05 23.7 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_27 PF13463.6 CDK98517.1 - 6.5e-05 23.3 0.0 0.00019 21.9 0.0 1.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain TrmB PF01978.19 CDK98517.1 - 0.0015 18.4 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 CDK98517.1 - 0.0026 17.6 0.1 0.0051 16.7 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_10 PF04967.12 CDK98517.1 - 0.0079 16.0 0.1 0.021 14.6 0.0 1.7 2 0 0 2 2 1 1 HTH DNA binding domain HTH_Crp_2 PF13545.6 CDK98517.1 - 0.0082 16.1 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Ad_Cy_reg PF16701.5 CDK98517.1 - 0.011 15.5 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase regulatory domain HTH_11 PF08279.12 CDK98517.1 - 0.012 15.5 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 HTH domain HTH_psq PF05225.16 CDK98517.1 - 0.012 15.3 0.0 0.035 13.9 0.0 1.7 1 0 0 1 1 1 0 helix-turn-helix, Psq domain DUF4423 PF14394.6 CDK98517.1 - 0.014 15.1 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) HrcA_DNA-bdg PF03444.15 CDK98517.1 - 0.014 15.1 0.0 0.025 14.2 0.0 1.5 1 1 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HTH_CodY PF08222.11 CDK98517.1 - 0.025 14.1 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain HTH_23 PF13384.6 CDK98517.1 - 0.026 14.3 0.0 0.063 13.1 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain MarR PF01047.22 CDK98517.1 - 0.031 14.2 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_28 PF13518.6 CDK98517.1 - 0.042 14.0 0.0 0.66 10.2 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.6 CDK98517.1 - 0.083 12.5 0.1 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_47 PF16221.5 CDK98517.1 - 0.088 12.4 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 winged helix-turn-helix HTH_IclR PF09339.10 CDK98517.1 - 0.099 12.5 0.2 0.26 11.1 0.1 1.8 2 0 0 2 2 2 0 IclR helix-turn-helix domain Sigma70_r3 PF04539.16 CDK98517.1 - 0.15 12.2 0.0 0.45 10.7 0.0 1.8 2 0 0 2 2 2 0 Sigma-70 region 3 Acetyltransf_1 PF00583.25 CDK98518.1 - 4.4e-07 30.1 0.0 5.3e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CDK98518.1 - 0.032 14.2 0.0 0.049 13.6 0.0 1.2 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_10 PF13673.7 CDK98518.1 - 0.049 13.6 0.0 0.075 13.0 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDK98518.1 - 0.067 13.3 0.0 0.13 12.3 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CDK98518.1 - 0.082 13.0 0.0 0.097 12.8 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Radical_SAM PF04055.21 CDK98519.1 - 2.1e-14 54.3 0.1 3.3e-14 53.6 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily SPASM PF13186.6 CDK98519.1 - 9.9e-11 42.0 0.7 2.7e-10 40.6 0.7 1.8 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Fer4_22 PF17179.4 CDK98520.1 - 9.4e-36 122.6 14.0 2.8e-35 121.0 11.8 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDK98520.1 - 2.7e-09 37.4 6.8 0.00052 20.6 2.0 2.7 2 1 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK98520.1 - 1.1e-07 31.8 10.3 0.0013 18.8 0.4 2.6 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDK98520.1 - 5.6e-07 29.8 5.5 0.00079 19.6 0.1 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDK98520.1 - 7.6e-07 28.9 13.9 0.0036 17.3 2.3 2.8 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 CDK98520.1 - 1.5e-06 28.6 7.9 0.0013 19.2 1.4 2.8 2 1 1 3 3 3 3 4Fe-4S dicluster domain Fer4 PF00037.27 CDK98520.1 - 2.9e-05 23.7 15.7 0.0064 16.3 3.7 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 CDK98520.1 - 8.3e-05 22.5 14.5 0.011 15.8 1.6 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 CDK98520.1 - 0.00012 22.2 15.0 0.006 16.7 14.2 2.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDK98520.1 - 0.00029 21.2 12.6 0.00029 21.2 12.6 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDK98520.1 - 0.00033 20.7 14.7 0.0035 17.4 0.2 2.7 3 0 0 3 3 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDK98520.1 - 0.0054 17.6 16.6 0.11 13.5 1.1 2.8 2 1 1 3 3 3 3 4Fe-4S double cluster binding domain Fer4_3 PF12798.7 CDK98520.1 - 0.027 15.4 4.2 0.027 15.4 4.2 3.1 3 0 0 3 3 2 0 4Fe-4S binding domain GST_N_5 PF18485.1 CDK98520.1 - 0.037 14.4 0.1 0.07 13.5 0.1 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Fer4_4 PF12800.7 CDK98520.1 - 0.089 13.3 19.5 0.8 10.4 2.8 3.0 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_15 PF13459.6 CDK98520.1 - 0.37 11.6 11.9 0.86 10.4 0.8 3.0 2 0 0 2 2 2 0 4Fe-4S single cluster domain cNMP_binding PF00027.29 CDK98521.1 - 7.3e-12 45.2 0.0 9.8e-12 44.8 0.0 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain NAD_binding_1 PF00175.21 CDK98522.1 - 1.2e-16 61.3 0.0 1.8e-16 60.8 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DHODB_Fe-S_bind PF10418.9 CDK98522.1 - 1.7e-08 34.2 4.0 3.4e-08 33.2 4.0 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B FAD_binding_6 PF00970.24 CDK98522.1 - 0.0036 17.6 0.0 0.0075 16.6 0.0 1.6 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain Oxidored_q6 PF01058.22 CDK98523.1 - 4e-25 88.2 0.0 5.7e-25 87.6 0.0 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Transketolase_C PF02780.20 CDK98523.1 - 0.043 13.7 0.0 0.068 13.1 0.0 1.3 1 0 0 1 1 1 0 Transketolase, C-terminal domain ATP-grasp_6 PF18419.1 CDK98523.1 - 0.051 13.2 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp-like domain Zn_clus PF00172.18 CDK98523.1 - 0.49 10.6 3.7 3.1 8.0 0.5 2.5 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain NiFeSe_Hases PF00374.19 CDK98524.1 - 1.1e-29 103.7 2.3 1.7e-17 63.5 0.0 3.3 1 1 1 3 3 3 3 Nickel-dependent hydrogenase HTH_IclR PF09339.10 CDK98525.1 - 8.7e-17 60.7 0.1 3.7e-16 58.7 0.2 2.1 2 0 0 2 2 2 1 IclR helix-turn-helix domain IclR PF01614.18 CDK98525.1 - 1.5e-11 44.3 0.0 2.2e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial transcriptional regulator TrmB PF01978.19 CDK98525.1 - 0.00015 21.6 0.0 0.00033 20.5 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 CDK98525.1 - 0.0037 17.3 0.1 0.012 15.7 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 CDK98525.1 - 0.017 15.0 0.4 0.053 13.4 0.1 2.0 2 0 0 2 2 2 0 MarR family HTH_27 PF13463.6 CDK98525.1 - 0.021 15.3 0.1 0.067 13.7 0.0 1.8 2 0 0 2 2 2 0 Winged helix DNA-binding domain HTH_5 PF01022.20 CDK98525.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family AOX PF01786.17 CDK98525.1 - 0.16 11.5 0.1 0.25 10.9 0.1 1.2 1 0 0 1 1 1 0 Alternative oxidase Lactamase_B PF00753.27 CDK98526.1 - 1.1e-14 54.9 2.2 1.1e-14 54.9 2.2 2.0 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDK98526.1 - 4.1e-12 46.0 1.8 8.2e-11 41.8 0.3 3.0 3 0 0 3 3 3 1 Beta-lactamase superfamily domain RMMBL PF07521.12 CDK98526.1 - 2.3e-07 30.6 0.3 4.3e-06 26.6 0.0 2.6 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 CDK98526.1 - 0.01 15.7 0.2 2.9 7.8 0.1 3.6 3 1 0 4 4 4 0 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 CDK98526.1 - 0.066 12.6 0.0 1 8.7 0.0 2.1 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain Hydrolase PF00702.26 CDK98526.1 - 0.087 13.1 0.0 2 8.7 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Pan_kinase PF03309.14 CDK98527.1 - 4.9e-72 242.1 0.0 5.9e-72 241.9 0.0 1.1 1 0 0 1 1 1 1 Type III pantothenate kinase ROK PF00480.20 CDK98527.1 - 0.06 12.8 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 ROK family BPL_LplA_LipB PF03099.19 CDK98528.1 - 2.4e-10 40.5 0.0 3.2e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_LplA_LipB_2 PF16917.5 CDK98528.1 - 4.9e-10 39.2 0.6 1.1e-09 38.1 0.3 1.6 1 1 0 2 2 2 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 CDK98528.1 - 1e-06 28.5 0.5 1.8e-06 27.7 0.5 1.4 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain Proton_antipo_M PF00361.20 CDK98529.1 - 3.9e-85 285.6 18.5 3.9e-85 285.6 18.5 2.1 2 1 0 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_M PF00361.20 CDK98530.1 - 3e-88 295.8 26.8 3e-88 295.8 26.8 1.7 2 0 0 2 2 2 1 Proton-conducting membrane transporter Oxidored_q5_N PF01059.17 CDK98530.1 - 6.5e-05 23.0 1.7 6.5e-05 23.0 1.7 4.0 5 1 0 5 5 5 1 NADH-ubiquinone oxidoreductase chain 4, amino terminus Proton_antipo_M PF00361.20 CDK98531.1 - 5.9e-91 304.7 22.7 5.9e-91 304.7 22.7 1.7 2 0 0 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 CDK98531.1 - 6.1e-23 80.7 6.1 6.1e-23 80.7 6.1 3.5 3 0 0 3 3 3 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus NADH5_C PF06455.11 CDK98531.1 - 1.7e-10 40.8 15.2 2.5e-05 24.0 0.0 4.3 4 0 0 4 4 4 2 NADH dehydrogenase subunit 5 C-terminus Proton_antipo_C PF01010.19 CDK98531.1 - 5e-06 26.3 0.1 1.1e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus DUF3953 PF13129.6 CDK98531.1 - 0.57 10.0 0.0 0.57 10.0 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF3953) Oxidored_q2 PF00420.24 CDK98532.1 - 3.3e-25 87.7 12.0 4e-25 87.5 12.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Gram_pos_anchor PF00746.21 CDK98532.1 - 0.04 13.9 4.8 0.43 10.6 0.1 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif HTH_45 PF14947.6 CDK98532.1 - 0.094 12.7 0.3 0.15 12.1 0.3 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix Oxidored_q3 PF00499.20 CDK98533.1 - 7.5e-38 129.5 22.9 1.1e-37 129.0 22.9 1.2 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 YdjM PF04307.14 CDK98533.1 - 0.64 9.3 9.3 4.8 6.5 9.2 2.4 1 1 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase Fer4 PF00037.27 CDK98534.1 - 1.2e-14 53.4 15.8 6.4e-09 35.3 3.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 CDK98534.1 - 1.3e-13 51.3 9.4 2e-13 50.7 9.4 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDK98534.1 - 1.8e-11 44.8 5.2 1.1e-05 26.2 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 CDK98534.1 - 1.6e-09 37.7 9.4 2.7e-09 37.1 9.4 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK98534.1 - 3.3e-09 36.7 21.5 2.5e-06 27.5 12.8 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDK98534.1 - 4.3e-09 36.7 18.5 8.8e-06 26.1 11.0 2.0 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDK98534.1 - 1.4e-08 34.8 22.7 4e-06 26.9 12.8 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDK98534.1 - 1.2e-07 31.4 11.2 0.0014 18.6 1.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 CDK98534.1 - 2.5e-07 30.5 17.0 0.00017 21.5 4.9 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CDK98534.1 - 2.7e-06 27.5 10.9 0.00032 21.0 2.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 CDK98534.1 - 6.2e-05 23.5 12.2 0.0059 17.1 12.7 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_13 PF13370.6 CDK98534.1 - 0.0019 18.7 13.2 0.25 11.9 3.6 2.5 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 CDK98534.1 - 0.0039 18.0 16.5 0.0095 16.8 4.2 2.2 2 0 0 2 2 2 1 4Fe-4S binding domain c-SKI_SMAD_bind PF08782.10 CDK98534.1 - 0.004 17.3 4.8 0.31 11.3 0.5 2.2 1 1 1 2 2 2 2 c-SKI Smad4 binding domain Fer4_18 PF13746.6 CDK98534.1 - 0.0072 16.5 8.2 0.24 11.6 1.0 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain ETF_QO PF05187.13 CDK98534.1 - 0.2 11.8 5.0 0.67 10.1 0.6 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 CDK98534.1 - 0.26 12.2 11.1 2.1 9.3 1.7 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain NADHdh PF00146.21 CDK98535.1 - 1.9e-132 441.1 25.4 2.2e-132 440.9 25.4 1.0 1 0 0 1 1 1 1 NADH dehydrogenase Molybdopterin PF00384.22 CDK98536.1 - 5e-69 233.3 0.0 6.7e-68 229.6 0.0 2.0 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 CDK98536.1 - 8.7e-20 70.6 0.5 2e-19 69.4 0.5 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 CDK98536.1 - 1.5e-17 62.8 0.2 3.3e-17 61.7 0.2 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.11 CDK98536.1 - 2.7e-14 53.6 0.1 7.1e-14 52.2 0.1 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.27 CDK98536.1 - 6.1e-11 42.1 0.6 6.1e-11 42.1 0.6 2.3 1 1 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 CDK98536.1 - 0.005 16.6 2.2 0.025 14.3 0.4 2.7 2 1 1 3 3 3 1 Thiamine pyrophosphate enzyme, central domain PRD1_DD PF11087.8 CDK98536.1 - 1.4 8.7 4.3 4.6 7.0 0.1 3.0 3 0 0 3 3 3 0 PRD1 phage membrane DNA delivery Complex1_51K PF01512.17 CDK98537.1 - 8.5e-49 165.3 0.0 1.2e-48 164.8 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 CDK98537.1 - 1.2e-30 105.4 0.1 2e-30 104.7 0.1 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 CDK98537.1 - 3.5e-09 36.4 0.0 7.8e-09 35.3 0.0 1.6 1 0 0 1 1 1 1 SLBB domain GHMP_kinases_C PF08544.13 CDK98537.1 - 0.0057 17.0 0.1 5.1 7.5 0.1 2.7 2 0 0 2 2 2 2 GHMP kinases C terminal 2Fe-2S_thioredx PF01257.19 CDK98538.1 - 5.7e-62 207.9 0.4 6.6e-62 207.7 0.4 1.0 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Complex1_49kDa PF00346.19 CDK98539.1 - 1.9e-129 430.5 0.0 3.1e-129 429.8 0.0 1.3 2 0 0 2 2 2 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 CDK98539.1 - 0.0057 15.6 0.0 0.02 13.8 0.0 1.8 3 0 0 3 3 3 1 Nickel-dependent hydrogenase Complex1_30kDa PF00329.19 CDK98540.1 - 4.4e-47 159.7 0.0 5.6e-47 159.4 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit Oxidored_q6 PF01058.22 CDK98541.1 - 2.2e-22 79.3 0.2 2.9e-22 78.9 0.2 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Oxidored_q4 PF00507.19 CDK98542.1 - 7e-41 138.4 1.4 7e-41 138.4 1.4 1.4 1 1 1 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 DUF945 PF06097.11 CDK98542.1 - 0.53 9.3 1.3 0.67 9.0 1.3 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) Promethin PF16015.5 CDK98542.1 - 7.2 6.6 11.2 23 5.0 11.2 1.9 1 1 0 1 1 1 0 Promethin Bac_DNA_binding PF00216.21 CDK98543.1 - 1.8e-33 114.6 0.0 2e-33 114.5 0.0 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 CDK98543.1 - 5.5e-06 26.5 0.0 5.6e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_euk_2 PF18289.1 CDK98543.1 - 0.00023 21.3 0.0 0.00032 20.8 0.0 1.2 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 DUF2267 PF10025.9 CDK98543.1 - 0.045 14.0 0.0 0.064 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) HU-CCDC81_bac_2 PF18175.1 CDK98543.1 - 0.1 12.5 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 2C_adapt PF08793.10 CDK98543.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 2-cysteine adaptor domain Lon_C PF05362.13 CDK98544.1 - 7.8e-98 326.0 2.2 1.7e-97 324.9 1.7 1.8 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 CDK98544.1 - 1e-41 143.1 0.1 1e-41 143.1 0.1 1.7 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 CDK98544.1 - 1.3e-19 71.0 0.0 3.1e-19 69.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 CDK98544.1 - 2.6e-08 33.8 0.0 4.9e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 CDK98544.1 - 2.6e-08 33.9 0.0 6.7e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_PrkA PF08298.11 CDK98544.1 - 3.6e-06 26.2 0.0 6.7e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.12 CDK98544.1 - 0.002 17.9 0.0 0.0048 16.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 CDK98544.1 - 0.0022 17.7 0.0 0.0048 16.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 CDK98544.1 - 0.0052 17.1 0.3 0.086 13.1 0.1 2.8 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 CDK98544.1 - 0.0053 17.2 3.9 0.0079 16.6 0.1 3.0 3 1 0 3 3 3 1 AAA ATPase domain AAA_28 PF13521.6 CDK98544.1 - 0.0072 16.6 0.4 2.7 8.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CDK98544.1 - 0.01 15.9 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDK98544.1 - 0.011 15.9 1.4 0.015 15.4 0.1 1.9 2 0 0 2 2 1 0 AAA domain AAA_3 PF07726.11 CDK98544.1 - 0.016 15.0 0.0 0.039 13.8 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CDK98544.1 - 0.034 14.1 0.0 0.079 12.9 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ECH_2 PF16113.5 CDK98544.1 - 0.057 12.9 1.4 0.52 9.7 1.0 2.2 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase AAA_18 PF13238.6 CDK98544.1 - 0.061 13.9 1.5 0.11 13.0 0.1 2.2 2 1 1 3 3 2 0 AAA domain TsaE PF02367.17 CDK98544.1 - 0.12 12.4 0.0 0.34 10.9 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SKI PF01202.22 CDK98544.1 - 0.35 11.0 0.1 0.35 11.0 0.1 2.2 2 0 0 2 2 2 0 Shikimate kinase Laps PF10169.9 CDK98544.1 - 0.73 10.4 10.4 4.4 7.9 4.1 2.6 1 1 1 2 2 2 0 Learning-associated protein ABC_tran PF00005.27 CDK98544.1 - 0.87 10.1 3.9 1.9 9.0 0.1 2.8 2 1 0 2 2 2 0 ABC transporter AAA_2 PF07724.14 CDK98545.1 - 5.5e-50 169.8 0.0 1e-49 168.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) zf-C4_ClpX PF06689.13 CDK98545.1 - 2.5e-20 72.1 3.8 6.7e-20 70.7 3.8 1.8 1 0 0 1 1 1 1 ClpX C4-type zinc finger AAA PF00004.29 CDK98545.1 - 3.9e-17 62.9 0.0 1.1e-16 61.4 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CDK98545.1 - 1.1e-14 54.2 0.7 3.9e-14 52.5 0.2 2.1 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein Mg_chelatase PF01078.21 CDK98545.1 - 4.8e-07 29.4 0.6 0.00022 20.7 0.9 3.1 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDK98545.1 - 9.4e-07 28.9 0.0 1.1e-05 25.5 0.1 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDK98545.1 - 4.4e-06 26.5 0.2 1.4e-05 24.9 0.2 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDK98545.1 - 4.8e-06 26.9 0.2 8.3e-05 22.9 0.2 2.5 1 1 0 1 1 1 1 AAA domain MCM PF00493.23 CDK98545.1 - 1.6e-05 24.1 0.1 2.8e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain Sigma54_activat PF00158.26 CDK98545.1 - 0.00044 20.0 0.0 0.074 12.8 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 CDK98545.1 - 0.0006 20.2 0.1 0.0044 17.4 0.1 2.0 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 CDK98545.1 - 0.001 19.0 0.0 0.0029 17.6 0.0 1.7 2 0 0 2 2 1 1 Rad17 P-loop domain Sigma54_activ_2 PF14532.6 CDK98545.1 - 0.0015 18.7 0.0 0.0042 17.2 0.0 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_7 PF12775.7 CDK98545.1 - 0.0017 17.9 0.0 0.0056 16.2 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_14 PF13173.6 CDK98545.1 - 0.0028 17.7 0.0 0.0065 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CDK98545.1 - 0.0044 16.9 0.0 0.06 13.3 0.0 2.6 3 0 0 3 3 2 1 NACHT domain IstB_IS21 PF01695.17 CDK98545.1 - 0.0053 16.5 0.1 0.011 15.5 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein ABC_tran PF00005.27 CDK98545.1 - 0.0063 17.0 0.0 0.017 15.6 0.0 1.8 2 0 0 2 2 1 1 ABC transporter PduV-EutP PF10662.9 CDK98545.1 - 0.011 15.5 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 CDK98545.1 - 0.013 15.5 0.1 0.026 14.5 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 CDK98545.1 - 0.013 15.9 0.0 0.033 14.6 0.0 1.8 1 1 0 1 1 1 0 RNA helicase TIP49 PF06068.13 CDK98545.1 - 0.014 14.7 0.1 0.033 13.4 0.1 1.5 1 1 1 2 2 2 0 TIP49 P-loop domain AAA_25 PF13481.6 CDK98545.1 - 0.016 14.8 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CDK98545.1 - 0.02 13.9 0.0 0.083 11.9 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_18 PF13238.6 CDK98545.1 - 0.027 15.0 0.0 0.067 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CDK98545.1 - 0.039 13.8 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_3 PF07726.11 CDK98545.1 - 0.053 13.4 0.2 0.35 10.7 0.1 2.5 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDK98545.1 - 0.056 13.2 0.0 0.09 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDK98545.1 - 0.058 12.7 0.3 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 KaiC AAA_19 PF13245.6 CDK98545.1 - 0.063 13.6 0.4 2.9 8.2 0.2 2.6 2 1 1 3 3 2 0 AAA domain Flavodoxin_2 PF02525.17 CDK98545.1 - 0.067 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin-like fold AAA_28 PF13521.6 CDK98545.1 - 0.079 13.2 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 CDK98545.1 - 0.088 12.3 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_33 PF13671.6 CDK98545.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain CLP_protease PF00574.23 CDK98546.1 - 1.2e-85 286.0 0.1 1.5e-85 285.7 0.1 1.1 1 0 0 1 1 1 1 Clp protease DUF4055 PF13264.6 CDK98546.1 - 0.027 14.6 0.1 0.051 13.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4055) Trigger_C PF05698.14 CDK98547.1 - 3.1e-40 137.8 7.8 1.1e-39 136.1 0.2 3.3 3 0 0 3 3 3 1 Bacterial trigger factor protein (TF) C-terminus Trigger_N PF05697.13 CDK98547.1 - 4.1e-38 130.9 1.2 4.1e-38 130.9 1.2 2.9 3 1 0 3 3 3 1 Bacterial trigger factor protein (TF) FKBP_C PF00254.28 CDK98547.1 - 8.3e-15 54.9 0.2 4.9e-14 52.4 0.1 2.3 3 0 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase T4-gp15_tss PF16724.5 CDK98547.1 - 0.18 11.6 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 T4-like virus Myoviridae tail sheath stabiliser Protoglobin PF11563.8 CDK98549.1 - 1.9e-39 135.1 1.3 3.9e-39 134.1 0.2 2.0 2 0 0 2 2 2 1 Protoglobin MCPsignal PF00015.21 CDK98549.1 - 2.5e-32 112.0 53.5 2.6e-31 108.7 28.5 3.7 1 1 2 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 CDK98549.1 - 0.00081 19.4 11.8 0.077 13.0 0.7 3.3 2 2 1 3 3 3 2 Protein of unknown function (DUF1664) DUF948 PF06103.11 CDK98549.1 - 0.0063 16.7 26.6 0.52 10.6 1.7 4.8 1 1 2 4 4 4 4 Bacterial protein of unknown function (DUF948) LPP PF04728.13 CDK98549.1 - 0.021 15.2 1.9 0.021 15.2 1.9 6.0 5 3 1 6 6 5 0 Lipoprotein leucine-zipper Sec5 PF15469.6 CDK98549.1 - 0.054 13.3 0.3 0.15 11.8 0.2 1.8 1 1 0 1 1 1 0 Exocyst complex component Sec5 Syntaxin-6_N PF09177.11 CDK98549.1 - 0.099 13.2 12.1 1.8 9.2 0.3 3.3 2 2 0 2 2 2 0 Syntaxin 6, N-terminal TMPIT PF07851.13 CDK98549.1 - 0.11 11.7 5.9 0.78 8.9 2.6 2.2 2 0 0 2 2 2 0 TMPIT-like protein Rogdi_lz PF10259.9 CDK98549.1 - 0.53 9.7 3.5 1.6 8.1 3.5 1.8 1 1 0 1 1 1 0 Rogdi leucine zipper containing protein FlaC_arch PF05377.11 CDK98549.1 - 1.2 9.6 4.9 1 9.8 0.3 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Golgin_A5 PF09787.9 CDK98549.1 - 1.2 8.5 10.0 0.41 10.1 6.5 1.7 1 1 0 1 1 1 0 Golgin subfamily A member 5 Laminin_I PF06008.14 CDK98549.1 - 4.5 6.9 32.3 0.46 10.2 9.4 3.9 1 1 2 4 4 4 0 Laminin Domain I DUF3450 PF11932.8 CDK98549.1 - 4.6 6.5 26.6 0.084 12.2 3.9 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF3450) SKA1 PF07160.12 CDK98549.1 - 8 6.2 7.4 20 4.9 1.8 2.7 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 1 PIN_8 PF18476.1 CDK98549.1 - 9.9 5.9 10.0 3.7 7.4 4.0 2.4 1 1 2 3 3 3 0 PIN like domain CorA PF01544.18 CDK98550.1 - 1.4e-52 178.8 0.2 1.7e-52 178.5 0.2 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MCD PF05292.11 CDK98551.1 - 8.8e-112 372.8 0.0 1.2e-111 372.5 0.0 1.1 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase C-terminal domain MCD_N PF17408.2 CDK98551.1 - 2.2e-26 91.8 0.2 4.9e-26 90.7 0.2 1.6 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase N-terminal domain Carb_kinase PF01256.17 CDK98552.1 - 2.8e-48 164.5 2.7 2.8e-48 164.5 2.7 1.6 2 0 0 2 2 2 1 Carbohydrate kinase YjeF_N PF03853.15 CDK98552.1 - 2.2e-37 128.6 0.2 6.1e-37 127.1 0.2 1.8 1 0 0 1 1 1 1 YjeF-related protein N-terminus Gmad1 PF10647.9 CDK98552.1 - 0.014 15.2 0.2 0.028 14.2 0.2 1.5 1 0 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain Phos_pyr_kin PF08543.12 CDK98552.1 - 0.056 12.8 0.0 0.09 12.1 0.0 1.2 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase DAO PF01266.24 CDK98553.1 - 5.4e-75 253.2 3.9 6.2e-75 253.0 3.9 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDK98553.1 - 5.4e-11 42.3 0.0 5.1e-05 22.7 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CDK98553.1 - 6.4e-10 38.8 1.1 0.00044 19.6 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain FAD_binding_2 PF00890.24 CDK98553.1 - 6.5e-10 38.7 2.3 3e-05 23.3 0.7 2.2 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 CDK98553.1 - 8.2e-08 31.4 0.0 0.0059 15.4 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox PF00070.27 CDK98553.1 - 1.3e-07 32.1 0.2 0.00059 20.3 0.3 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDK98553.1 - 2.4e-07 30.9 0.2 5.7e-07 29.7 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CDK98553.1 - 3.9e-07 29.7 0.3 0.0024 17.2 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase ApbA PF02558.16 CDK98553.1 - 2.3e-06 27.4 0.0 3.9e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 CDK98553.1 - 8.9e-05 22.4 0.8 0.00017 21.5 0.8 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.14 CDK98553.1 - 0.00018 20.5 2.0 0.03 13.2 0.0 2.3 2 0 0 2 2 2 2 Tryptophan halogenase UDPG_MGDP_dh_N PF03721.14 CDK98553.1 - 0.00029 20.4 1.6 0.00046 19.8 1.6 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_oxidored PF12831.7 CDK98553.1 - 0.00056 19.4 0.1 0.014 14.8 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CDK98553.1 - 0.00072 18.9 0.0 0.26 10.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CDK98553.1 - 0.0036 17.3 0.0 0.0069 16.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 CDK98553.1 - 0.005 17.3 0.0 0.0082 16.6 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding GIDA PF01134.22 CDK98553.1 - 0.0054 15.9 0.2 0.12 11.5 0.5 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CDK98553.1 - 0.0067 15.8 0.1 0.011 15.0 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 CDK98553.1 - 0.0093 16.0 2.2 0.92 9.5 0.1 2.5 2 1 0 2 2 2 1 FAD-NAD(P)-binding TrkA_N PF02254.18 CDK98553.1 - 0.013 15.7 0.7 0.044 14.1 0.2 2.0 2 0 0 2 2 2 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 CDK98553.1 - 0.015 15.5 0.1 0.025 14.8 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Thi4 PF01946.17 CDK98553.1 - 0.019 14.3 0.5 0.031 13.5 0.1 1.5 2 0 0 2 2 1 0 Thi4 family NAD_binding_2 PF03446.15 CDK98553.1 - 0.033 14.4 0.0 0.056 13.6 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CDK98553.1 - 0.038 13.4 0.1 0.072 12.4 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CDK98553.1 - 0.052 13.5 0.2 0.084 12.8 0.2 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 CDK98553.1 - 0.054 14.1 0.1 0.14 12.8 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.25 CDK98553.1 - 0.077 12.4 0.6 0.14 11.6 0.6 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Glyco_transf_4 PF13439.6 CDK98553.1 - 0.091 12.7 0.2 0.39 10.7 0.1 2.0 1 1 0 1 1 1 0 Glycosyltransferase Family 4 GMC_oxred_N PF00732.19 CDK98553.1 - 0.13 11.6 0.0 17 4.7 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase ThiF PF00899.21 CDK98553.1 - 0.13 11.5 0.1 0.27 10.6 0.1 1.4 1 0 0 1 1 1 0 ThiF family DUF1188 PF06690.11 CDK98553.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) Epimerase PF01370.21 CDK98553.1 - 0.17 11.3 0.3 0.27 10.7 0.3 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Competence PF03772.16 CDK98554.1 - 1.1e-64 218.3 40.9 1.1e-64 218.3 40.9 2.1 2 0 0 2 2 2 1 Competence protein DUF4131 PF13567.6 CDK98554.1 - 3.8e-13 49.4 4.2 3.8e-13 49.4 4.2 4.4 3 1 0 4 4 4 2 Domain of unknown function (DUF4131) ABC_tran PF00005.27 CDK98556.1 - 4.1e-29 101.8 0.0 6.1e-29 101.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98556.1 - 5.4e-14 52.7 0.2 3.7e-06 27.0 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDK98556.1 - 1.3e-05 25.8 0.0 1.9e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDK98556.1 - 2.1e-05 24.1 0.0 0.12 11.8 0.0 2.4 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 CDK98556.1 - 0.00077 19.2 1.5 0.12 12.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CDK98556.1 - 0.0014 18.2 2.9 0.0039 16.8 0.1 2.6 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 CDK98556.1 - 0.0014 18.3 0.0 0.0029 17.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDK98556.1 - 0.0018 18.6 0.3 0.017 15.4 0.3 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDK98556.1 - 0.0021 18.4 0.8 0.0048 17.3 0.8 1.6 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CDK98556.1 - 0.004 17.1 0.0 0.0084 16.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_15 PF13175.6 CDK98556.1 - 0.0053 16.5 0.0 0.014 15.1 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 CDK98556.1 - 0.011 15.9 0.0 0.024 14.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CDK98556.1 - 0.016 15.1 0.5 0.27 11.1 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA PF00004.29 CDK98556.1 - 0.027 14.9 0.0 0.12 12.9 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 CDK98556.1 - 0.03 14.6 0.0 0.059 13.6 0.0 1.6 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit cobW PF02492.19 CDK98556.1 - 0.032 13.8 0.1 0.071 12.7 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DLIC PF05783.11 CDK98556.1 - 0.05 12.4 0.0 0.068 12.0 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_24 PF13479.6 CDK98556.1 - 0.052 13.3 0.0 0.38 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 CDK98556.1 - 0.058 13.0 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_27 PF13514.6 CDK98556.1 - 0.078 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDK98556.1 - 0.11 13.1 0.0 2.1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 CDK98556.1 - 0.11 11.1 0.0 0.15 10.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDK98556.1 - 0.14 12.2 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 CDK98556.1 - 0.15 12.3 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 CDK98556.1 - 0.16 9.5 0.1 0.22 9.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ATPase PF06745.13 CDK98556.1 - 0.23 10.8 0.0 3.9 6.8 0.0 2.1 2 0 0 2 2 2 0 KaiC tRNA-synt_1c PF00749.21 CDK98557.1 - 2.8e-93 312.2 0.0 3.5e-93 312.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Citrate_synt PF00285.21 CDK98558.1 - 5.1e-132 440.3 0.0 5.9e-132 440.1 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Rotamase_3 PF13616.6 CDK98561.1 - 2.7e-55 185.9 0.0 1.4e-27 96.5 0.0 2.0 1 1 1 2 2 2 2 PPIC-type PPIASE domain Rotamase PF00639.21 CDK98561.1 - 1.6e-54 182.9 0.0 6.8e-26 91.1 0.0 2.0 2 0 0 2 2 2 2 PPIC-type PPIASE domain Rotamase_2 PF13145.6 CDK98561.1 - 6.8e-17 62.4 0.0 4.5e-07 30.7 0.0 2.1 2 0 0 2 2 2 2 PPIC-type PPIASE domain KN_motif PF12075.8 CDK98561.1 - 0.0012 18.6 0.1 2.3 8.1 0.0 2.4 2 0 0 2 2 2 2 KN motif Yippee-Mis18 PF03226.14 CDK98562.1 - 9.8e-06 25.7 0.0 1.8e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Zn_ribbon_SprT PF17283.2 CDK98562.1 - 0.012 15.5 0.5 1.3 9.0 0.1 2.2 2 0 0 2 2 2 0 SprT-like zinc ribbon domain DZR PF12773.7 CDK98562.1 - 0.012 15.6 1.1 0.38 10.8 1.1 2.5 1 1 0 1 1 1 0 Double zinc ribbon Ribosomal_S27e PF01667.17 CDK98562.1 - 0.024 14.4 2.8 3.2 7.5 0.1 3.1 2 1 1 3 3 3 0 Ribosomal protein S27 Zn_ribbon_recom PF13408.6 CDK98562.1 - 0.029 14.9 4.8 2.2 8.9 0.1 2.6 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain DNA_RNApol_7kD PF03604.13 CDK98562.1 - 0.035 13.8 1.4 0.9 9.3 0.0 2.3 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf_UBZ PF18439.1 CDK98562.1 - 0.067 12.8 0.8 1 9.0 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Nudix_N_2 PF14803.6 CDK98562.1 - 1.7 8.6 8.1 4.7 7.2 0.1 2.7 3 0 0 3 3 3 0 Nudix N-terminal zinc_ribbon_2 PF13240.6 CDK98562.1 - 3.7 7.4 5.8 27 4.6 0.3 2.9 3 0 0 3 3 3 0 zinc-ribbon domain RNA_POL_M_15KD PF02150.16 CDK98562.1 - 7.5 6.5 6.3 17 5.4 0.1 3.0 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit 2Fe-2S_thioredx PF01257.19 CDK98563.1 - 7e-05 22.7 0.0 0.00013 21.9 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Suc_Fer-like PF06999.12 CDK98563.1 - 0.013 15.4 0.1 0.025 14.4 0.1 1.6 1 1 0 1 1 1 0 Sucrase/ferredoxin-like DUF1636 PF07845.11 CDK98563.1 - 0.031 14.7 0.0 0.04 14.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1636) DUF4170 PF13773.6 CDK98564.1 - 9.7e-16 57.7 0.2 2.2e-07 30.9 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4170) LPD28 PF18843.1 CDK98564.1 - 0.047 13.3 0.0 9.1 6.0 0.0 2.3 2 0 0 2 2 2 0 Large polyvalent protein associated domain 28 DUF977 PF06163.11 CDK98564.1 - 0.048 13.6 0.0 3.3 7.7 0.0 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF977) ACBP PF00887.19 CDK98564.1 - 0.12 12.5 0.0 16 5.8 0.0 2.2 2 0 0 2 2 2 0 Acyl CoA binding protein GIDA PF01134.22 CDK98566.1 - 5.6e-108 361.5 0.0 6.6e-108 361.3 0.0 1.0 1 0 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 CDK98566.1 - 5.7e-06 26.1 0.7 6.1e-05 22.8 0.1 2.4 2 1 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDK98566.1 - 4.7e-05 22.7 0.2 0.00029 20.0 0.0 2.1 2 1 1 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.6 CDK98566.1 - 0.00012 22.2 0.1 0.0003 21.0 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CDK98566.1 - 0.00023 20.5 0.0 0.00063 19.1 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDK98566.1 - 0.0012 19.3 0.0 0.0055 17.2 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CDK98566.1 - 0.0073 15.6 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 CDK98566.1 - 0.0076 15.6 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CDK98566.1 - 0.17 10.6 0.0 0.25 10.0 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 CDK98566.1 - 0.2 10.7 0.0 0.29 10.1 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NIT PF08376.10 CDK98567.1 - 2.1e-38 133.1 14.9 3e-38 132.6 14.9 1.2 1 0 0 1 1 1 1 Nitrate and nitrite sensing TIP39 PF14980.6 CDK98567.1 - 2 8.4 5.2 7 6.6 0.1 3.5 3 0 0 3 3 3 0 TIP39 peptide MCPsignal PF00015.21 CDK98568.1 - 6.3e-27 94.5 26.9 6.3e-27 94.5 26.9 2.3 1 1 1 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK98568.1 - 6e-07 29.7 0.1 6e-07 29.7 0.1 3.5 5 0 0 5 5 5 1 HAMP domain Baculo_PEP_C PF04513.12 CDK98568.1 - 0.012 15.7 3.8 0.012 15.7 3.8 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 CDK98568.1 - 0.096 12.7 11.5 0.25 11.4 2.3 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Porin_8 PF16966.5 CDK98568.1 - 0.098 11.6 0.1 0.13 11.2 0.1 1.1 1 0 0 1 1 1 0 Porin-like glycoporin RafY YjbH PF06082.11 CDK98568.1 - 0.85 8.3 7.1 1.1 8.0 7.1 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH DUF948 PF06103.11 CDK98568.1 - 1.1 9.6 25.7 0.58 10.4 0.6 5.0 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Vps53_N PF04100.12 CDK98568.1 - 2.7 6.9 8.8 0.78 8.6 1.0 2.5 3 0 0 3 3 3 0 Vps53-like, N-terminal STAS_2 PF13466.6 CDK98569.1 - 2.4e-14 53.4 1.2 2.7e-14 53.2 1.2 1.0 1 0 0 1 1 1 1 STAS domain STAS PF01740.21 CDK98569.1 - 6.4e-11 41.9 0.0 7.6e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 STAS domain DUF2478 PF10649.9 CDK98570.1 - 1.4e-50 171.1 0.2 1.5e-50 170.9 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2478) Glyco_trans_4_4 PF13579.6 CDK98570.1 - 2.8e-05 24.6 1.9 3.6e-05 24.2 1.9 1.1 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain NTPase_1 PF03266.15 CDK98570.1 - 4.2e-05 23.5 0.0 9.1e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 NTPase Glyco_transf_4 PF13439.6 CDK98570.1 - 0.0014 18.7 0.0 0.0019 18.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase Family 4 HATPase_c PF02518.26 CDK98571.1 - 1.9e-25 89.6 0.0 3.6e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK98571.1 - 9e-19 67.7 0.0 2.2e-18 66.5 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CDK98571.1 - 1.3e-15 57.1 0.1 1.3e-15 57.1 0.1 2.6 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 CDK98571.1 - 1.6e-14 54.1 0.8 3.4e-14 53.0 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CDK98571.1 - 4.4e-09 36.5 0.0 1.1e-08 35.3 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CDK98571.1 - 7.5e-09 35.6 0.0 2.7e-08 33.8 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDK98571.1 - 8.5e-07 28.9 0.6 1.5e-05 24.9 0.0 3.1 3 0 0 3 3 3 1 PAS domain HATPase_c_3 PF13589.6 CDK98571.1 - 0.0018 18.1 0.0 0.0034 17.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_10 PF13596.6 CDK98571.1 - 0.021 15.4 0.0 0.054 14.1 0.0 1.8 1 0 0 1 1 1 0 PAS domain HATPase_c_2 PF13581.6 CDK98571.1 - 0.029 14.3 0.6 0.12 12.4 0.0 2.3 3 0 0 3 3 3 0 Histidine kinase-like ATPase domain DUF1192 PF06698.11 CDK98571.1 - 0.6 10.2 6.7 2 8.6 6.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Response_reg PF00072.24 CDK98572.1 - 3.9e-48 162.3 0.5 5.6e-24 84.5 0.0 2.6 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 CDK98572.1 - 6.8e-24 84.5 0.1 1.5e-23 83.4 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98572.1 - 3.2e-10 39.9 0.0 3.2e-10 39.9 0.0 3.5 4 1 0 4 4 4 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CDK98572.1 - 8.2e-05 22.5 0.0 0.00018 21.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CDK98572.1 - 0.00035 20.4 0.0 0.0012 18.7 0.0 1.8 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 CDK98572.1 - 0.017 15.1 1.0 0.068 13.1 0.0 2.4 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain Methyltransf_25 PF13649.6 CDK98572.1 - 0.13 13.0 0.0 0.65 10.7 0.0 2.2 1 0 0 1 1 1 0 Methyltransferase domain Apolipoprotein PF01442.18 CDK98572.1 - 0.47 10.3 12.7 2 8.3 12.6 2.1 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain T2SSF PF00482.23 CDK98572.1 - 0.87 9.5 4.2 5.5 7.0 0.0 3.2 3 1 0 3 3 3 0 Type II secretion system (T2SS), protein F CheB_methylest PF01339.17 CDK98573.1 - 1.8e-51 174.2 0.1 4.1e-51 173.1 0.0 1.6 2 0 0 2 2 2 1 CheB methylesterase Response_reg PF00072.24 CDK98573.1 - 2.3e-20 72.8 0.3 4.2e-20 72.0 0.3 1.4 1 0 0 1 1 1 1 Response regulator receiver domain DAZAP2 PF11029.8 CDK98573.1 - 0.0099 16.8 0.2 0.019 15.9 0.2 1.5 1 0 0 1 1 1 1 DAZ associated protein 2 (DAZAP2) GFO_IDH_MocA PF01408.22 CDK98573.1 - 0.15 12.9 0.0 0.28 12.0 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Response_reg PF00072.24 CDK98574.1 - 1.5e-23 83.1 0.3 4.3e-23 81.6 0.2 1.9 2 0 0 2 2 2 1 Response regulator receiver domain CheW PF01584.19 CDK98574.1 - 4.3e-16 58.8 2.9 7e-16 58.1 0.6 2.2 2 0 0 2 2 2 1 CheW-like domain Hpt PF01627.23 CDK98574.1 - 3.5e-13 49.6 0.9 3.5e-13 49.6 0.9 2.6 2 0 0 2 2 2 1 Hpt domain HATPase_c PF02518.26 CDK98574.1 - 1.3e-12 48.2 0.0 5.8e-12 46.1 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MCPsignal PF00015.21 CDK98575.1 - 3.2e-29 101.9 27.4 3.2e-29 101.9 27.4 3.8 2 1 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK98575.1 - 2.2e-09 37.5 0.1 2.2e-09 37.5 0.1 4.5 5 0 0 5 5 5 1 HAMP domain PilJ PF13675.6 CDK98575.1 - 4e-08 33.3 3.7 4e-08 33.3 3.7 5.4 2 2 3 5 5 5 2 Type IV pili methyl-accepting chemotaxis transducer N-term CheW PF01584.19 CDK98576.1 - 1.2e-28 99.4 0.0 1.6e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 CheW-like domain CheR PF01739.18 CDK98577.1 - 4.2e-50 169.9 0.0 6.7e-50 169.3 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain TPR_1 PF00515.28 CDK98577.1 - 2.6e-08 33.3 0.1 0.038 13.8 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDK98577.1 - 8.6e-08 31.7 2.3 0.1 12.8 0.2 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDK98577.1 - 2e-05 24.4 0.0 0.0018 18.3 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Methyltransf_25 PF13649.6 CDK98577.1 - 0.00047 20.8 0.0 0.51 11.1 0.0 3.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK98577.1 - 0.00095 19.9 0.0 0.0076 17.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain TPR_11 PF13414.6 CDK98577.1 - 0.0012 18.5 0.0 1.5 8.6 0.0 2.5 2 0 0 2 2 2 2 TPR repeat TPR_4 PF07721.14 CDK98577.1 - 0.0019 18.6 6.1 3 8.7 0.1 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDK98577.1 - 0.0094 16.7 6.3 5.2 8.1 0.6 4.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDK98577.1 - 0.015 15.8 0.4 0.046 14.2 0.4 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDK98577.1 - 0.018 15.7 2.0 0.018 15.7 2.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat T6SS_VasJ PF16989.5 CDK98577.1 - 0.04 13.4 0.4 0.071 12.6 0.4 1.3 1 0 0 1 1 1 0 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ TPR_10 PF13374.6 CDK98577.1 - 0.082 12.8 3.4 4.4 7.3 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDK98577.1 - 0.2 12.1 0.9 2.6 8.6 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDK98577.1 - 0.3 11.3 12.3 0.15 12.2 3.1 2.7 2 1 1 3 3 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDK98577.1 - 0.32 11.3 4.3 11 6.4 0.5 2.9 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDK98577.1 - 1.6 9.5 6.4 49 4.9 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat CheW PF01584.19 CDK98578.1 - 2.7e-14 53.0 0.0 3.1e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 CheW-like domain AAA_31 PF13614.6 CDK98579.1 - 2.2e-48 164.5 0.3 2.9e-48 164.1 0.3 1.1 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CDK98579.1 - 1.1e-18 67.5 0.1 1.8e-18 66.8 0.1 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 CDK98579.1 - 4.2e-10 39.3 0.5 2.5e-05 23.7 0.2 2.1 2 0 0 2 2 2 2 ATPase MipZ Fer4_NifH PF00142.18 CDK98579.1 - 1.5e-09 37.7 0.2 2.6e-08 33.6 0.2 2.1 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 CDK98579.1 - 2.5e-09 37.0 3.3 1.6e-08 34.3 3.3 2.0 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 CDK98579.1 - 4e-09 36.3 0.0 1.6e-08 34.3 0.0 1.8 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ArsA_ATPase PF02374.15 CDK98579.1 - 0.00034 19.9 1.1 0.00072 18.8 0.5 1.7 2 0 0 2 2 2 1 Anion-transporting ATPase VirC1 PF07015.11 CDK98579.1 - 0.073 12.4 0.2 0.44 9.8 0.0 1.9 2 0 0 2 2 2 0 VirC1 protein SRP54 PF00448.22 CDK98579.1 - 0.16 11.6 1.0 0.39 10.3 0.1 2.0 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain sCache_2 PF17200.4 CDK98580.1 - 1e-11 45.0 0.1 1.2e-11 44.7 0.1 1.2 1 0 0 1 1 1 1 Single Cache domain 2 dCache_2 PF08269.11 CDK98580.1 - 2.3e-09 36.9 0.0 3.2e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Cache domain MCM PF00493.23 CDK98580.1 - 0.078 12.1 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain MCPsignal PF00015.21 CDK98581.1 - 6.3e-31 107.5 43.1 1.3e-30 106.5 21.9 4.5 1 1 2 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK98581.1 - 1.6e-07 31.6 0.3 1.6e-07 31.6 0.3 4.6 6 0 0 6 6 6 1 HAMP domain 4HB_MCP_1 PF12729.7 CDK98581.1 - 2.5e-06 27.2 1.0 2.5e-06 27.2 1.0 3.7 2 1 0 3 3 3 1 Four helix bundle sensory module for signal transduction Laminin_I PF06008.14 CDK98581.1 - 0.0018 18.1 5.7 0.0018 18.1 5.7 5.2 2 1 4 6 6 6 1 Laminin Domain I TelA PF05816.11 CDK98581.1 - 0.0019 17.4 14.9 0.0047 16.1 6.6 3.9 4 1 0 4 4 4 1 Toxic anion resistance protein (TelA) COG5 PF10392.9 CDK98581.1 - 0.0037 17.4 1.5 0.055 13.6 0.8 2.6 2 0 0 2 2 2 1 Golgi transport complex subunit 5 PIN_5 PF08745.11 CDK98581.1 - 0.044 13.2 3.7 0.093 12.1 3.7 1.5 1 0 0 1 1 1 0 PINc domain ribonuclease DUF1664 PF07889.12 CDK98581.1 - 0.068 13.2 12.5 2.5 8.2 3.2 4.3 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 CDK98581.1 - 0.1 12.8 29.2 0.18 12.1 0.6 6.0 2 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) PLDc_2 PF13091.6 CDK98581.1 - 0.33 10.8 1.6 0.62 9.9 0.3 2.0 2 0 0 2 2 2 0 PLD-like domain AAA_13 PF13166.6 CDK98581.1 - 2.4 6.7 8.8 0.88 8.1 5.5 1.6 1 1 0 1 1 1 0 AAA domain DUF812 PF05667.11 CDK98581.1 - 2.7 6.8 13.1 0.89 8.4 10.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Patatin PF01734.22 CDK98582.1 - 6.7e-30 104.8 0.0 9.4e-30 104.3 0.0 1.2 1 0 0 1 1 1 1 Patatin-like phospholipase COX4_pro PF03626.14 CDK98583.1 - 5.5e-10 39.5 6.8 6.9e-10 39.2 6.8 1.1 1 0 0 1 1 1 1 Prokaryotic Cytochrome C oxidase subunit IV DUF2976 PF11190.8 CDK98583.1 - 0.15 11.8 5.0 0.095 12.5 1.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2976) DUF1435 PF07256.12 CDK98583.1 - 0.54 10.4 5.8 1.7 8.8 5.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1435) DUF4212 PF13937.6 CDK98583.1 - 4.3 7.8 7.7 1.1e+02 3.3 7.7 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4212) Kinocilin PF15033.6 CDK98583.1 - 8.3 6.1 6.6 1.1 8.9 1.0 2.0 1 1 1 2 2 2 0 Kinocilin protein COX3 PF00510.18 CDK98584.1 - 3.4e-15 56.6 12.2 7.4e-15 55.5 12.2 1.5 1 1 0 1 1 1 1 Cytochrome c oxidase subunit III PMT_4TMC PF16192.5 CDK98584.1 - 0.21 11.2 5.6 0.65 9.6 0.2 2.1 2 0 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase Ldr_toxin PF13940.6 CDK98584.1 - 0.39 10.8 4.3 1.2 9.2 0.4 2.5 2 0 0 2 2 2 0 Toxin Ldr, type I toxin-antitoxin system Hpt PF01627.23 CDK98585.1 - 2.6e-07 30.8 1.4 1.7e-06 28.2 2.1 1.9 1 1 1 2 2 2 1 Hpt domain PMSR PF01625.21 CDK98586.1 - 1.2e-61 207.4 0.0 1.4e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase HATPase_c PF02518.26 CDK98587.1 - 3.9e-32 111.1 0.0 8e-32 110.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK98587.1 - 6.7e-25 87.4 0.1 2.1e-24 85.9 0.1 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CDK98587.1 - 1.4e-19 69.9 1.5 3.2e-17 62.3 0.1 3.8 3 1 0 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 CDK98587.1 - 1.1e-09 38.0 0.0 0.00045 20.2 0.0 3.3 2 0 0 2 2 2 2 PAS domain PAS_9 PF13426.7 CDK98587.1 - 6.2e-06 26.4 0.0 0.0016 18.6 0.0 3.7 3 1 1 4 4 4 1 PAS domain PAS PF00989.25 CDK98587.1 - 1.8e-05 24.7 0.0 0.014 15.4 0.0 3.0 3 0 0 3 3 3 2 PAS fold Hpt PF01627.23 CDK98587.1 - 2.1e-05 24.7 2.2 2.1e-05 24.7 2.2 2.3 2 0 0 2 2 2 1 Hpt domain PAS_3 PF08447.12 CDK98587.1 - 0.00012 22.3 0.0 0.19 12.0 0.0 2.9 2 0 0 2 2 2 2 PAS fold PAS_7 PF12860.7 CDK98587.1 - 0.00015 21.9 0.0 21 5.3 0.0 4.6 3 1 1 4 4 4 0 PAS fold PAS_4 PF08448.10 CDK98587.1 - 0.0095 16.2 2.6 7.9 6.8 0.0 4.3 3 2 1 4 4 4 1 PAS fold HATPase_c_3 PF13589.6 CDK98587.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PilZ PF07238.14 CDK98588.1 - 0.0001 22.5 0.2 0.00015 22.1 0.2 1.2 1 0 0 1 1 1 1 PilZ domain MCPsignal PF00015.21 CDK98591.1 - 2.2e-24 86.2 28.2 2.2e-24 86.2 28.2 3.4 2 1 1 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain 4HB_MCP_1 PF12729.7 CDK98591.1 - 1.3e-17 63.9 5.8 7.2e-17 61.5 0.1 3.3 2 2 1 3 3 3 1 Four helix bundle sensory module for signal transduction TarH PF02203.15 CDK98591.1 - 2.8e-15 56.7 2.7 2.8e-15 56.7 2.7 3.9 5 1 0 5 5 3 1 Tar ligand binding domain homologue PAS_3 PF08447.12 CDK98591.1 - 1.4e-12 47.7 0.0 4.9e-12 46.0 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CDK98591.1 - 4e-09 36.7 0.0 2.1e-08 34.4 0.0 2.1 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 CDK98591.1 - 1.8e-06 27.9 0.0 9.8e-06 25.5 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 CDK98591.1 - 5.4e-06 26.6 3.1 0.00019 21.6 0.0 4.1 4 0 0 4 4 4 1 PAS fold PAS_8 PF13188.7 CDK98591.1 - 0.00037 20.5 0.0 0.0021 18.0 0.0 2.3 2 0 0 2 2 2 1 PAS domain Laminin_I PF06008.14 CDK98591.1 - 0.032 13.9 18.5 0.47 10.1 7.1 3.3 1 1 2 3 3 3 0 Laminin Domain I DUF1664 PF07889.12 CDK98591.1 - 0.13 12.3 12.2 0.66 10.0 0.9 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 CDK98591.1 - 0.26 11.6 3.9 0.93 9.8 1.3 2.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Laminin_II PF06009.12 CDK98591.1 - 0.49 10.4 12.4 2.1 8.4 1.1 2.9 2 0 0 2 2 2 0 Laminin Domain II Atg14 PF10186.9 CDK98591.1 - 0.63 9.1 1.9 1.3 8.0 0.7 1.8 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HAMP PF00672.25 CDK98591.1 - 0.79 10.2 8.9 0.96 9.9 0.1 4.8 4 0 0 4 4 3 0 HAMP domain Snapin_Pallidin PF14712.6 CDK98591.1 - 0.91 10.0 8.0 0.47 10.9 0.2 3.7 3 1 1 4 4 4 0 Snapin/Pallidin Syntaxin-6_N PF09177.11 CDK98591.1 - 1.8 9.1 11.1 0.98 10.0 0.4 3.8 3 1 0 3 3 3 0 Syntaxin 6, N-terminal CAP_N PF01213.19 CDK98591.1 - 3.7 6.9 7.8 1 8.8 3.2 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal BLOC1_2 PF10046.9 CDK98591.1 - 8.2 6.8 9.2 18 5.7 0.4 4.2 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Rubrerythrin PF02915.17 CDK98592.1 - 7.8e-10 39.3 2.1 5.3e-09 36.6 2.1 1.9 1 1 0 1 1 1 1 Rubrerythrin Ferritin_2 PF13668.6 CDK98592.1 - 9.2e-08 32.4 0.6 1.3e-07 31.9 0.6 1.3 1 1 0 1 1 1 1 Ferritin-like domain Ferritin PF00210.24 CDK98592.1 - 0.0016 18.4 2.4 0.8 9.6 0.1 2.2 1 1 1 2 2 2 2 Ferritin-like domain DUF2383 PF09537.10 CDK98592.1 - 0.0017 18.7 0.7 0.052 13.9 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF2383) DUF4142 PF13628.6 CDK98592.1 - 0.047 13.9 0.5 7 6.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4142) tRNA_Me_trans PF03054.16 CDK98593.1 - 1.8e-111 372.4 0.0 2.1e-111 372.2 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.21 CDK98593.1 - 1e-05 25.4 0.0 1.2e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.17 CDK98593.1 - 5.9e-05 22.3 0.0 0.0001 21.5 0.0 1.3 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 CDK98593.1 - 0.0089 15.5 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.19 CDK98593.1 - 0.067 12.5 0.0 0.093 12.0 0.0 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase ThiI PF02568.14 CDK98593.1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.5 1 1 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.20 CDK98593.1 - 0.19 11.5 0.1 0.34 10.6 0.1 1.5 1 0 0 1 1 1 0 PP-loop family DUF599 PF04654.12 CDK98594.1 - 3.2e-61 206.4 12.2 3.7e-61 206.2 12.2 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF599 DUF3925 PF13063.6 CDK98594.1 - 0.044 14.0 1.8 0.044 14.0 1.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3925) Fe-S_assembly PF04384.13 CDK98595.1 - 5.3e-32 110.2 3.5 5.7e-32 110.1 3.5 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster assembly Fer2 PF00111.27 CDK98596.1 - 5.6e-15 55.1 0.1 7e-15 54.8 0.1 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain zf-RING_7 PF02591.15 CDK98596.1 - 0.017 15.3 0.0 0.04 14.1 0.0 1.7 1 0 0 1 1 1 0 C4-type zinc ribbon domain DUF2766 PF10964.8 CDK98596.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2766) HSP70 PF00012.20 CDK98597.1 - 5.6e-173 576.3 1.7 6.5e-173 576.1 1.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDK98597.1 - 1.1e-15 57.4 5.1 3e-14 52.6 2.6 2.5 2 0 0 2 2 2 2 MreB/Mbl protein Raco_middle PF17651.1 CDK98597.1 - 0.1 12.3 0.0 1.5 8.5 0.0 2.5 2 0 0 2 2 2 0 RACo middle region HSCB_C PF07743.13 CDK98598.1 - 9.3e-17 61.3 2.4 1.4e-16 60.7 0.5 2.0 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 CDK98598.1 - 3.7e-07 30.2 0.1 6.7e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain zf-ribbon_3 PF13248.6 CDK98598.1 - 0.0041 16.5 1.1 0.0041 16.5 1.1 1.8 2 0 0 2 2 2 1 zinc-ribbon domain DZR PF12773.7 CDK98598.1 - 0.022 14.8 1.6 0.028 14.4 0.6 1.7 2 0 0 2 2 2 0 Double zinc ribbon HscB_4_cys PF18256.1 CDK98598.1 - 0.12 12.2 3.9 0.35 10.7 3.9 1.9 1 1 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif Fe-S_biosyn PF01521.20 CDK98599.1 - 2e-23 82.7 0.0 2.3e-23 82.5 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis NifU_N PF01592.16 CDK98600.1 - 1e-56 190.6 0.2 1.1e-56 190.4 0.2 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Aminotran_5 PF00266.19 CDK98601.1 - 9.6e-87 291.3 0.0 1.1e-86 291.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CDK98601.1 - 5e-07 29.3 0.3 5.6e-07 29.1 0.3 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CDK98601.1 - 3.3e-06 26.7 2.4 5.1e-06 26.0 2.4 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CDK98602.1 - 1e-61 209.0 0.0 1.2e-61 208.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CDK98602.1 - 7.8e-06 25.4 1.4 2.8e-05 23.6 1.4 1.9 1 1 0 1 1 1 1 Beta-eliminating lyase Rrf2 PF02082.20 CDK98603.1 - 7.3e-28 96.7 0.1 1.1e-27 96.2 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator HrcA_DNA-bdg PF03444.15 CDK98603.1 - 0.00022 20.8 0.0 0.00034 20.2 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding MarR_2 PF12802.7 CDK98603.1 - 0.0042 17.0 0.1 0.012 15.4 0.0 1.8 2 0 0 2 2 2 1 MarR family HTH_47 PF16221.5 CDK98603.1 - 0.067 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 winged helix-turn-helix HTH_46 PF15977.5 CDK98603.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA binding Hexapep PF00132.24 CDK98604.1 - 3.1e-13 48.9 6.5 7.6e-07 28.6 0.3 3.1 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDK98604.1 - 5.8e-05 22.8 8.7 0.00073 19.2 0.7 3.0 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase SATase_N PF06426.14 CDK98604.1 - 6.5e-05 23.3 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 Serine acetyltransferase, N-terminal SlyX PF04102.12 CDK98604.1 - 0.04 14.5 0.3 0.071 13.7 0.3 1.3 1 0 0 1 1 1 0 SlyX Hydrolase_4 PF12146.8 CDK98605.1 - 2e-11 43.7 0.2 6e-08 32.2 0.1 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 CDK98605.1 - 1.3e-09 38.1 0.0 3.3e-09 36.8 0.0 1.3 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 CDK98605.1 - 1.9e-09 37.3 0.7 4.7e-05 23.0 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CDK98605.1 - 2.5e-08 33.9 0.2 1.5e-06 28.0 0.2 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDK98605.1 - 1.1e-06 29.4 0.2 0.00069 20.3 0.1 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family DLH PF01738.18 CDK98605.1 - 2e-05 24.2 0.0 2.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 CDK98605.1 - 0.019 14.8 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CDK98605.1 - 0.039 13.8 0.0 0.091 12.6 0.0 1.4 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Cytochrom_D1 PF02239.16 CDK98606.1 - 9.9e-101 336.9 0.0 4.6e-100 334.7 0.0 1.8 1 1 0 1 1 1 1 Cytochrome D1 heme domain Cytochrome_CBB3 PF13442.6 CDK98606.1 - 3.1e-12 46.6 0.0 1.3e-11 44.7 0.0 2.1 2 0 0 2 2 2 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDK98606.1 - 5.6e-05 24.2 1.0 0.00092 20.3 1.0 2.3 1 1 0 1 1 1 1 Cytochrome c Lactonase PF10282.9 CDK98606.1 - 0.0083 15.4 0.0 2 7.6 0.0 2.3 2 0 0 2 2 2 2 Lactonase, 7-bladed beta-propeller PQQ_3 PF13570.6 CDK98606.1 - 0.014 15.8 0.1 27 5.4 0.0 4.0 4 0 0 4 4 4 0 PQQ-like domain PD40 PF07676.12 CDK98606.1 - 0.036 14.0 0.2 0.18 11.8 0.2 2.2 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 CDK98606.1 - 0.051 13.9 0.0 16 5.9 0.0 3.1 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Radical_SAM PF04055.21 CDK98607.1 - 2.2e-20 73.7 0.0 3.3e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CDK98607.1 - 3.8e-09 36.9 0.0 6.1e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CDK98607.1 - 2.1e-05 24.7 0.0 3.3e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain AsnC_trans_reg2 PF17805.1 CDK98608.1 - 9.8e-23 80.1 0.0 1.5e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 AsnC-like ligand binding domain HTH_AsnC-type PF13404.6 CDK98608.1 - 8.8e-07 28.7 0.1 1.5e-06 27.9 0.1 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain AsnC_trans_reg2 PF17805.1 CDK98609.1 - 1.6e-25 89.0 0.1 2.2e-25 88.6 0.1 1.2 1 0 0 1 1 1 1 AsnC-like ligand binding domain HTH_AsnC-type PF13404.6 CDK98609.1 - 4.4e-11 42.4 0.0 8.6e-11 41.5 0.0 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 CDK98609.1 - 0.0066 16.0 0.3 0.033 13.8 0.3 2.0 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 CDK98609.1 - 0.097 12.7 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 Lrp/AsnC ligand binding domain AsnC_trans_reg2 PF17805.1 CDK98610.1 - 2.8e-24 85.1 0.0 3.9e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 AsnC-like ligand binding domain HTH_AsnC-type PF13404.6 CDK98610.1 - 0.0078 16.0 0.1 0.0078 16.0 0.1 2.2 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain AsnC_trans_reg2 PF17805.1 CDK98611.1 - 1.7e-19 69.7 0.0 2.7e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 AsnC-like ligand binding domain HTH_AsnC-type PF13404.6 CDK98611.1 - 4.6e-10 39.2 0.3 1.6e-09 37.4 0.1 2.0 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain DprA_WH PF17782.1 CDK98611.1 - 0.0092 16.1 0.7 2.9 8.1 0.1 2.3 2 0 0 2 2 2 2 DprA winged helix domain DAO_C PF16901.5 CDK98611.1 - 0.047 13.6 0.1 0.094 12.6 0.1 1.5 2 0 0 2 2 2 0 C-terminal domain of alpha-glycerophosphate oxidase Cytochrom_D1 PF02239.16 CDK98612.1 - 6.4e-107 357.3 0.0 7.4e-107 357.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome D1 heme domain Lactonase PF10282.9 CDK98612.1 - 1.1e-05 24.9 0.0 0.02 14.2 0.0 3.0 2 1 0 3 3 3 2 Lactonase, 7-bladed beta-propeller Cytochrome_CBB3 PF13442.6 CDK98613.1 - 2.5e-09 37.3 0.0 3.1e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDK98613.1 - 0.01 17.0 0.2 1.2 10.3 0.3 2.1 1 1 1 2 2 2 0 Cytochrome c TP_methylase PF00590.20 CDK98614.1 - 7.6e-51 173.1 1.6 8.7e-51 172.9 1.6 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases EB_dh PF09459.10 CDK98616.1 - 7e-51 173.6 0.1 5.4e-32 111.7 0.0 2.0 1 1 1 2 2 2 2 Ethylbenzene dehydrogenase Cytochrome_C7 PF14522.6 CDK98616.1 - 0.09 12.8 0.4 2.1 8.4 0.1 2.2 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c DUF1924 PF09086.11 CDK98616.1 - 0.24 11.8 1.4 0.59 10.5 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1924) Cytochrom_NNT PF03264.14 CDK98617.1 - 9.9e-76 253.3 8.7 1.2e-75 253.0 8.7 1.0 1 0 0 1 1 1 1 NapC/NirT cytochrome c family, N-terminal region Paired_CXXCH_1 PF09699.10 CDK98617.1 - 4.2e-05 23.2 11.6 0.039 13.7 3.4 3.6 3 1 0 3 3 3 3 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_C7 PF14522.6 CDK98617.1 - 5.3e-05 23.1 21.7 0.0035 17.3 9.8 3.2 1 1 2 3 3 3 3 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 CDK98617.1 - 0.00013 22.4 20.3 0.058 13.9 1.8 2.4 1 1 1 2 2 2 2 Cytochrome c3 Cytochrom_CIII PF02085.16 CDK98617.1 - 0.00026 21.3 20.1 0.08 13.3 9.7 2.5 1 1 0 2 2 2 2 Class III cytochrome C family PSCyt3 PF07627.11 CDK98617.1 - 0.72 10.2 19.7 1.4 9.2 2.7 3.7 1 1 3 4 4 4 0 Protein of unknown function (DUF1588) zf-C4pol PF14260.6 CDK98617.1 - 0.95 10.0 9.4 11 6.6 3.0 2.8 2 1 1 3 3 3 0 C4-type zinc-finger of DNA polymerase delta zf-CHY PF05495.12 CDK98617.1 - 2 9.0 17.1 0.32 11.5 4.2 2.8 2 1 1 3 3 3 0 CHY zinc finger Cytochrome_CBB3 PF13442.6 CDK98617.1 - 3.3 8.1 15.6 3.5 8.0 0.5 3.8 1 1 2 3 3 3 0 Cytochrome C oxidase, cbb3-type, subunit III DUF3795 PF12675.7 CDK98617.1 - 3.5 8.1 12.4 1.5 9.3 3.7 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3795) Fer4_18 PF13746.6 CDK98617.1 - 4.1 7.6 9.7 1.6 9.0 1.2 2.9 1 1 2 3 3 3 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDK98617.1 - 6.5 7.0 10.9 0.59 10.3 1.9 2.9 2 1 0 2 2 2 0 4Fe-4S dicluster domain Defensin_5 PF18251.1 CDK98617.1 - 9.1 6.5 9.8 72 3.6 0.1 3.9 4 0 0 4 4 4 0 Fungal defensin Copsin Cytochrom_D1 PF02239.16 CDK98618.1 - 6.4e-153 508.6 1.1 7.6e-153 508.4 1.1 1.0 1 0 0 1 1 1 1 Cytochrome D1 heme domain Cytochrome_CBB3 PF13442.6 CDK98618.1 - 8.5e-12 45.2 0.1 2.2e-11 43.9 0.1 1.8 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDK98618.1 - 0.00056 21.0 0.9 0.0089 17.2 0.9 2.4 1 1 0 1 1 1 1 Cytochrome c PQQ_3 PF13570.6 CDK98618.1 - 0.082 13.4 0.0 0.27 11.8 0.0 1.9 1 0 0 1 1 1 0 PQQ-like domain ANAPC4_WD40 PF12894.7 CDK98618.1 - 0.089 13.1 0.4 21 5.5 0.0 3.0 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2156 PF09924.9 CDK98618.1 - 0.1 11.6 0.0 0.17 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2156) DUF2683 PF10884.8 CDK98618.1 - 0.16 12.2 5.4 15 6.0 0.1 4.0 5 0 0 5 5 5 0 Protein of unknown function (DUF2683) cNMP_binding PF00027.29 CDK98619.1 - 3.6e-15 55.8 0.0 6.1e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 CDK98619.1 - 1.3e-13 50.7 1.5 4.9e-13 48.9 0.4 2.2 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain MarR_2 PF12802.7 CDK98619.1 - 0.046 13.6 0.8 0.52 10.3 0.0 2.8 2 1 1 3 3 3 0 MarR family HTH_24 PF13412.6 CDK98619.1 - 0.048 13.2 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding cNMP_binding PF00027.29 CDK98620.1 - 2.3e-16 59.6 0.0 3.7e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 CDK98620.1 - 1.1e-15 57.4 1.7 2e-15 56.5 1.7 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain COX2 PF00116.20 CDK98621.1 - 0.00053 19.9 0.0 0.00066 19.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain COX1 PF00115.20 CDK98622.1 - 2e-07 30.3 33.2 3.9e-07 29.3 33.2 1.5 1 1 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I ABC_tran PF00005.27 CDK98623.1 - 2.3e-25 89.7 0.0 3.1e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter BCA_ABC_TP_C PF12399.8 CDK98623.1 - 5.3e-09 35.8 0.1 1e-08 34.9 0.1 1.5 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_21 PF13304.6 CDK98623.1 - 4.9e-08 33.1 0.5 0.0052 16.6 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK98623.1 - 6.7e-05 22.4 0.1 0.00023 20.7 0.1 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDK98623.1 - 0.0014 19.2 0.2 0.0019 18.7 0.2 1.3 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CDK98623.1 - 0.0039 17.0 0.0 0.013 15.2 0.0 1.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_27 PF13514.6 CDK98623.1 - 0.004 16.8 0.0 0.011 15.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CDK98623.1 - 0.02 15.2 0.0 0.032 14.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDK98623.1 - 0.021 14.6 0.2 0.073 12.8 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDK98623.1 - 0.028 14.1 0.0 0.049 13.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 CDK98623.1 - 0.098 13.1 0.0 0.22 12.0 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CDK98624.1 - 8.1e-27 94.4 0.0 1.2e-26 93.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98624.1 - 6e-08 32.8 0.5 0.00033 20.6 0.1 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK98624.1 - 2.6e-05 23.8 0.1 0.089 12.2 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDK98624.1 - 0.0016 18.1 0.1 0.0032 17.2 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MukB PF04310.12 CDK98624.1 - 0.0028 17.5 0.1 0.0056 16.5 0.1 1.4 1 0 0 1 1 1 1 MukB N-terminal AAA_30 PF13604.6 CDK98624.1 - 0.0057 16.4 0.1 0.013 15.2 0.1 1.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDK98624.1 - 0.029 14.5 0.1 0.059 13.5 0.1 1.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDK98624.1 - 0.035 14.0 0.1 0.059 13.3 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase AIG1 PF04548.16 CDK98624.1 - 0.042 13.2 0.3 0.061 12.6 0.3 1.2 1 0 0 1 1 1 0 AIG1 family NTPase_1 PF03266.15 CDK98624.1 - 0.043 13.7 0.1 0.083 12.8 0.1 1.4 1 0 0 1 1 1 0 NTPase AAA_27 PF13514.6 CDK98624.1 - 0.044 13.4 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDK98624.1 - 0.061 13.2 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 CDK98624.1 - 0.069 12.3 0.5 0.2 10.8 0.5 1.8 1 1 0 1 1 1 0 NB-ARC domain NDK PF00334.19 CDK98624.1 - 0.095 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Nucleoside diphosphate kinase Zeta_toxin PF06414.12 CDK98624.1 - 0.1 11.8 0.2 0.37 10.0 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 CDK98624.1 - 0.12 12.9 0.0 0.17 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDK98624.1 - 0.13 12.6 0.1 0.23 11.8 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CDK98624.1 - 0.19 12.0 0.4 0.8 10.0 0.4 1.9 1 1 0 1 1 1 0 AAA domain Peripla_BP_6 PF13458.6 CDK98625.1 - 3e-89 300.0 12.0 3.9e-89 299.7 12.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Peripla_BP_5 PF13433.6 CDK98625.1 - 3.6e-17 62.4 1.8 3.8e-11 42.6 0.1 2.0 2 0 0 2 2 2 2 Periplasmic binding protein domain ANF_receptor PF01094.28 CDK98625.1 - 3.1e-07 29.8 0.4 4.9e-07 29.2 0.4 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region VasL PF12486.8 CDK98625.1 - 0.067 13.0 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 Type VI secretion system, EvfB, or VasL BPD_transp_2 PF02653.16 CDK98626.1 - 7.6e-38 130.2 46.2 9.1e-38 129.9 46.2 1.1 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component BPD_transp_2 PF02653.16 CDK98627.1 - 4.8e-35 121.0 30.2 4.8e-35 121.0 30.2 1.6 1 1 1 2 2 2 1 Branched-chain amino acid transport system / permease component Usp PF00582.26 CDK98628.1 - 1e-16 61.7 0.4 1.3e-07 32.2 0.1 2.9 2 1 0 2 2 2 2 Universal stress protein family MaoC_dehydratas PF01575.19 CDK98629.1 - 1.9e-12 46.8 0.0 2.3e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CDK98629.1 - 7.7e-09 35.8 0.0 1e-08 35.4 0.0 1.1 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase FabA PF07977.13 CDK98629.1 - 0.0036 16.9 0.0 0.0051 16.4 0.0 1.3 1 0 0 1 1 1 1 FabA-like domain DUF4197 PF13852.6 CDK98630.1 - 2.1e-67 226.7 0.1 2.5e-67 226.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4197) AsmA PF05170.14 CDK98631.1 - 5.4e-60 203.9 0.4 7.3e-30 104.3 0.0 2.1 1 1 0 2 2 2 2 AsmA family AsmA_2 PF13502.6 CDK98631.1 - 1.2e-25 90.5 10.5 7.6e-22 78.0 3.9 3.1 2 1 1 3 3 3 2 AsmA-like C-terminal region DUF748 PF05359.11 CDK98631.1 - 0.035 14.3 8.1 15 5.7 0.0 5.8 4 2 2 6 6 6 0 Domain of Unknown Function (DUF748) DHHA1 PF02272.19 CDK98631.1 - 2.1 8.8 6.5 0.56 10.6 0.3 2.7 2 0 0 2 2 2 0 DHHA1 domain OmpA PF00691.20 CDK98632.1 - 7.3e-14 51.9 0.2 1.4e-13 51.0 0.2 1.4 1 0 0 1 1 1 1 OmpA family SBF PF01758.16 CDK98633.1 - 4.4e-26 91.8 16.0 4.4e-26 91.8 16.0 1.6 2 0 0 2 2 2 1 Sodium Bile acid symporter family SBF_like PF13593.6 CDK98633.1 - 6.3e-19 68.4 22.3 7.9e-19 68.1 22.3 1.1 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Mem_trans PF03547.18 CDK98633.1 - 4.7e-05 21.9 15.0 4.7e-05 21.9 15.0 2.3 2 1 0 2 2 2 1 Membrane transport protein EMP70 PF02990.16 CDK98633.1 - 0.64 8.6 3.0 0.96 8.0 3.0 1.3 1 0 0 1 1 1 0 Endomembrane protein 70 UbiA PF01040.18 CDK98634.1 - 1.6e-29 103.0 33.7 2.2e-29 102.5 33.7 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF3099 PF11298.8 CDK98634.1 - 0.022 14.9 0.8 0.022 14.9 0.8 4.3 4 1 1 5 5 5 0 Protein of unknown function (DUF3099) DUF2198 PF09964.9 CDK98634.1 - 0.028 14.5 0.2 0.14 12.3 0.2 2.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2198) Ubie_methyltran PF01209.18 CDK98635.1 - 4.9e-68 228.9 0.0 5.9e-68 228.7 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CDK98635.1 - 3.8e-17 62.8 0.1 6.5e-17 62.0 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK98635.1 - 4.1e-16 59.4 0.0 6.3e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDK98635.1 - 2.1e-08 34.2 0.0 5.2e-08 32.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDK98635.1 - 1.1e-06 28.5 0.0 1.5e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK98635.1 - 2.7e-06 28.0 0.0 4.9e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 CDK98635.1 - 0.025 14.4 0.0 0.049 13.5 0.0 1.6 1 1 0 1 1 1 0 Hypothetical methyltransferase ABC2_membrane_2 PF12679.7 CDK98636.1 - 8.2e-17 61.4 17.3 1.4e-16 60.6 17.3 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_3 PF12698.7 CDK98636.1 - 1.6e-09 37.3 16.8 1.6e-09 37.3 16.8 1.9 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane PF01061.24 CDK98636.1 - 7.9e-08 32.0 20.8 7.9e-08 32.0 20.8 1.4 2 0 0 2 2 2 1 ABC-2 type transporter NosL PF05573.12 CDK98637.1 - 0.0049 17.2 0.0 0.0071 16.7 0.0 1.3 1 0 0 1 1 1 1 NosL ABC_tran PF00005.27 CDK98638.1 - 2.5e-23 83.1 0.0 4.2e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98638.1 - 1.2e-13 51.6 0.0 7.2e-08 32.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK98638.1 - 2.7e-07 30.3 0.1 0.00056 19.4 0.0 2.2 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 CDK98638.1 - 2e-05 24.4 0.1 0.011 15.5 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_15 PF13175.6 CDK98638.1 - 0.00073 19.3 0.0 0.29 10.8 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 CDK98638.1 - 0.0028 18.0 0.1 0.0079 16.6 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CDK98638.1 - 0.0044 17.0 0.0 0.0074 16.2 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 CDK98638.1 - 0.0049 17.4 0.0 0.0073 16.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDK98638.1 - 0.0083 15.8 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain TsaE PF02367.17 CDK98638.1 - 0.0096 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CDK98638.1 - 0.013 15.2 0.1 0.061 13.0 0.0 1.9 1 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 CDK98638.1 - 0.018 14.2 0.1 0.043 13.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MMR_HSR1 PF01926.23 CDK98638.1 - 0.021 14.9 0.0 0.047 13.8 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 CDK98638.1 - 0.021 14.1 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.6 CDK98638.1 - 0.028 14.0 0.0 0.065 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDK98638.1 - 0.035 14.4 0.1 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CDK98638.1 - 0.039 13.5 0.2 0.08 12.5 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CDK98638.1 - 0.056 13.6 0.0 0.19 11.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 CDK98638.1 - 0.084 11.8 0.1 0.24 10.4 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF3584 PF12128.8 CDK98638.1 - 0.096 10.2 0.1 0.13 9.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_28 PF13521.6 CDK98638.1 - 0.098 12.9 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 CDK98638.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain MobB PF03205.14 CDK98638.1 - 0.13 12.2 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.6 CDK98638.1 - 0.14 11.8 0.1 0.28 10.9 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CDK98638.1 - 0.23 11.0 0.0 0.35 10.4 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Fer4_5 PF12801.7 CDK98639.1 - 9.5e-14 51.1 18.3 1.3e-09 37.8 1.9 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_7 PF12838.7 CDK98639.1 - 3.7e-06 27.4 7.9 0.0011 19.5 0.5 3.5 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4 PF00037.27 CDK98639.1 - 7.3e-06 25.6 2.6 7.3e-06 25.6 2.6 3.7 4 0 0 4 4 4 1 4Fe-4S binding domain Fer4_16 PF13484.6 CDK98639.1 - 0.0012 19.8 0.5 0.0012 19.8 0.5 4.0 5 0 0 5 5 5 1 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 CDK98639.1 - 0.0013 18.8 10.6 0.007 16.5 8.0 2.8 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDK98639.1 - 0.002 18.3 8.9 0.0043 17.2 5.7 2.7 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK98639.1 - 0.0025 17.9 12.4 0.017 15.2 9.2 3.2 2 1 2 4 4 4 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDK98639.1 - 0.0028 17.6 4.4 0.0028 17.6 4.4 3.6 4 0 0 4 4 3 1 4Fe-4S binding domain Fer4_21 PF14697.6 CDK98639.1 - 0.0031 17.6 6.1 0.0031 17.6 6.1 2.9 2 1 0 3 3 3 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK98639.1 - 0.0048 16.9 3.2 0.0048 16.9 3.2 2.8 3 0 0 3 3 2 1 4Fe-4S binding domain Fer4_3 PF12798.7 CDK98639.1 - 0.0077 17.1 4.9 0.0077 17.1 4.9 4.2 4 0 0 4 4 4 1 4Fe-4S binding domain Fer4_4 PF12800.7 CDK98639.1 - 0.011 16.2 3.6 0.011 16.2 3.6 3.3 4 0 0 4 4 3 0 4Fe-4S binding domain Fer4_19 PF06902.11 CDK98639.1 - 0.042 13.9 1.5 0.087 12.9 1.5 1.5 1 0 0 1 1 1 0 Divergent 4Fe-4S mono-cluster Fer4_17 PF13534.6 CDK98639.1 - 0.41 11.2 15.4 1.9e+02 2.7 13.9 4.0 2 1 0 2 2 2 0 4Fe-4S dicluster domain DUF3493 PF11998.8 CDK98639.1 - 1.7 8.9 4.9 8 6.7 0.2 2.5 2 0 0 2 2 2 0 Low psii accumulation1 / Rep27 Fer4_8 PF13183.6 CDK98639.1 - 4.2 7.9 18.5 0.078 13.4 2.4 3.9 3 1 1 4 4 4 0 4Fe-4S dicluster domain Fer4 PF00037.27 CDK98640.1 - 1.8e-14 52.8 31.0 2.6e-06 27.0 6.0 4.5 4 0 0 4 4 4 4 4Fe-4S binding domain Fer4_16 PF13484.6 CDK98640.1 - 1e-13 52.0 15.7 0.00021 22.2 1.2 3.9 3 1 0 3 3 3 3 4Fe-4S double cluster binding domain Fer4_7 PF12838.7 CDK98640.1 - 4.6e-13 49.5 20.6 8.7e-08 32.6 6.6 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK98640.1 - 1.6e-11 43.7 36.4 0.00024 21.0 3.4 4.5 5 0 0 5 5 4 4 4Fe-4S binding domain Fer4_9 PF13187.6 CDK98640.1 - 3.2e-10 40.0 23.8 0.00011 22.3 1.9 3.3 2 1 1 3 3 3 3 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDK98640.1 - 1.8e-08 34.4 28.6 0.00012 22.2 1.4 4.0 3 1 1 4 4 4 3 4Fe-4S dicluster domain Fer4_4 PF12800.7 CDK98640.1 - 5.9e-08 32.6 29.9 0.003 17.9 3.8 4.4 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_10 PF13237.6 CDK98640.1 - 1.9e-06 27.9 26.5 0.0029 17.7 9.7 3.5 2 2 1 3 3 3 3 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDK98640.1 - 5.6e-06 26.9 38.5 0.0038 18.1 6.5 4.5 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_8 PF13183.6 CDK98640.1 - 8e-06 26.2 18.6 0.0023 18.3 0.0 3.7 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDK98640.1 - 2.7e-05 24.6 21.7 0.0089 16.6 0.4 3.6 3 1 0 3 3 3 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDK98640.1 - 0.00023 21.1 30.3 0.0041 17.1 1.9 4.6 5 0 0 5 5 4 2 4Fe-4S binding domain Fer4_22 PF17179.4 CDK98640.1 - 0.0003 21.6 14.8 0.043 14.7 1.0 3.5 3 1 0 3 3 3 2 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDK98640.1 - 0.00098 19.3 18.6 2 8.6 0.6 3.9 3 1 1 4 4 4 2 4Fe-4S dicluster domain Glyco_hydro_7 PF00840.20 CDK98640.1 - 0.081 11.6 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 7 NosD PF05048.13 CDK98641.1 - 9.9e-48 162.5 20.6 4e-45 154.0 13.9 2.1 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) Beta_helix PF13229.6 CDK98641.1 - 4.1e-32 111.2 28.5 1.2e-20 74.0 10.2 2.1 1 1 1 2 2 2 2 Right handed beta helix region DUF1565 PF07602.11 CDK98641.1 - 1.2e-07 31.4 11.9 3.7e-05 23.2 3.7 3.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1565) Pectate_lyase_3 PF12708.7 CDK98641.1 - 1.1e-05 25.3 8.7 1.1e-05 25.3 8.7 2.9 1 1 1 2 2 2 1 Pectate lyase superfamily protein Cytochrom_C PF00034.21 CDK98643.1 - 2e-17 64.1 2.4 2.9e-07 31.5 0.9 3.2 3 1 0 3 3 3 2 Cytochrome c Cytochrome_CBB3 PF13442.6 CDK98643.1 - 2e-16 60.0 1.1 1.8e-09 37.7 0.1 3.1 3 0 0 3 3 3 2 Cytochrome C oxidase, cbb3-type, subunit III Paired_CXXCH_1 PF09699.10 CDK98643.1 - 0.00079 19.1 1.6 0.4 10.5 0.2 2.4 2 0 0 2 2 2 2 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrom_C550 PF14495.6 CDK98643.1 - 0.0025 17.5 0.1 0.038 13.7 0.0 2.6 3 0 0 3 3 3 1 Cytochrome c-550 domain Cytochrom_C1 PF02167.15 CDK98643.1 - 0.11 12.2 0.2 12 5.5 0.1 2.3 2 0 0 2 2 2 0 Cytochrome C1 family Cytochrom_C PF00034.21 CDK98644.1 - 3.2e-20 73.1 3.5 4.5e-09 37.3 0.1 2.8 2 1 0 2 2 2 2 Cytochrome c Cytochrome_CBB3 PF13442.6 CDK98644.1 - 4.5e-16 58.9 0.8 1.6e-07 31.6 0.1 2.3 2 0 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III DUF3365 PF11845.8 CDK98644.1 - 4.7e-05 23.8 0.9 0.14 12.4 0.1 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3365) DHOR PF06537.11 CDK98644.1 - 0.0017 17.1 0.0 0.8 8.3 0.0 2.1 2 0 0 2 2 2 2 Di-haem oxidoreductase, putative peroxidase FixO PF02433.15 CDK98644.1 - 0.0045 16.5 0.7 9.4 5.6 0.1 3.5 2 2 2 4 4 4 2 Cytochrome C oxidase, mono-heme subunit/FixO Cytochrome_C7 PF14522.6 CDK98644.1 - 0.0047 16.9 0.0 3.8 7.6 0.0 2.2 2 0 0 2 2 2 2 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CDK98644.1 - 0.0053 16.5 0.7 2.2 8.1 0.0 2.3 2 0 0 2 2 2 2 Doubled CXXCH motif (Paired_CXXCH_1) DUF1924 PF09086.11 CDK98644.1 - 0.035 14.4 2.2 5.7 7.4 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1924) Cytochrom_c3_2 PF14537.6 CDK98644.1 - 0.044 14.2 0.1 13 6.3 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c3 Haem_bd PF14376.6 CDK98644.1 - 0.059 13.3 0.0 6.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Haem-binding domain PSCyt1 PF07635.11 CDK98644.1 - 0.11 13.1 2.7 7.1 7.3 0.1 2.7 2 0 0 2 2 2 0 Planctomycete cytochrome C nos_propeller PF18764.1 CDK98645.1 - 6.7e-34 115.6 0.3 2.7e-33 113.7 0.2 2.2 2 0 0 2 2 2 1 Nitrous oxide reductase propeller repeat Cupredoxin_1 PF13473.6 CDK98645.1 - 2.3e-08 34.1 0.0 5.6e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Cupredoxin-like domain COX2 PF00116.20 CDK98645.1 - 4.1e-05 23.5 0.0 8.5e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain Copper-bind PF00127.20 CDK98645.1 - 0.084 13.3 0.1 0.31 11.5 0.1 2.1 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family SCO1-SenC PF02630.14 CDK98646.1 - 3.8e-45 153.1 0.0 4.8e-45 152.8 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 CDK98646.1 - 0.0014 18.5 0.0 0.0021 18.0 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDK98647.1 - 5.8e-12 45.5 0.0 7.7e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CDK98647.1 - 1.9e-10 40.7 0.0 2.5e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 CDK98647.1 - 1.1e-05 25.7 0.0 1.5e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 CDK98647.1 - 3.1e-05 23.9 0.1 0.068 13.2 0.1 2.2 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 CDK98647.1 - 0.00052 20.4 0.0 0.0015 18.9 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDK98647.1 - 0.044 14.0 0.1 0.13 12.5 0.1 1.7 2 0 0 2 2 2 0 Thioredoxin-like PCuAC PF04314.13 CDK98648.1 - 2.6e-41 139.8 0.1 2.6e-41 139.8 0.1 1.8 2 0 0 2 2 2 1 Copper chaperone PCu(A)C PilZ PF07238.14 CDK98648.1 - 0.028 14.7 0.0 6.1 7.2 0.0 2.2 1 1 0 2 2 2 0 PilZ domain DUF2946 PF11162.8 CDK98649.1 - 0.0031 18.2 2.3 0.0039 17.9 2.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2946) Cytochrom_C PF00034.21 CDK98650.1 - 3.8e-08 34.4 0.0 6.9e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CDK98650.1 - 1.2e-07 31.9 1.3 1.2e-07 31.9 1.3 1.9 1 1 1 2 2 2 1 Cytochrome C oxidase, cbb3-type, subunit III ACR_tran PF00873.19 CDK98651.1 - 1.2e-258 860.8 19.2 1.3e-258 860.6 19.2 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family SecD_SecF PF02355.16 CDK98651.1 - 2.1e-05 24.0 23.0 0.00089 18.7 2.6 2.3 2 0 0 2 2 2 2 Protein export membrane protein CCB1 PF12046.8 CDK98651.1 - 3.4 7.0 8.1 0.13 11.6 1.3 2.1 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B HlyD_D23 PF16576.5 CDK98652.1 - 4.4e-09 35.9 0.0 8.8e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CDK98652.1 - 1.2e-07 32.4 4.1 1.3e-07 32.3 0.1 3.2 4 0 0 4 4 4 1 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDK98652.1 - 0.00024 20.9 4.1 0.66 9.9 0.1 3.9 4 0 0 4 4 4 2 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK98652.1 - 0.095 12.5 4.5 0.6 10.0 0.2 3.1 4 0 0 4 4 4 0 Biotin-requiring enzyme Arginase PF00491.21 CDK98654.1 - 2.7e-77 260.0 0.4 3.1e-77 259.8 0.4 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 CDK98654.1 - 0.19 12.0 0.1 0.29 11.3 0.1 1.2 1 0 0 1 1 1 0 UPF0489 domain Orn_Arg_deC_N PF02784.16 CDK98655.1 - 8.7e-36 123.5 0.0 1.1e-35 123.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CDK98655.1 - 3.2e-06 27.3 0.0 6.9e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ala_racemase_N PF01168.20 CDK98655.1 - 0.096 12.3 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain Sacchrp_dh_NADP PF03435.18 CDK98656.1 - 1.8e-31 109.1 0.0 4.9e-31 107.7 0.0 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Sacchrp_dh_C PF16653.5 CDK98656.1 - 8.2e-31 108.1 0.0 1.2e-30 107.6 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Hemerythrin PF01814.23 CDK98657.1 - 0.002 18.7 2.7 0.0027 18.3 2.7 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Fer4_2 PF12797.7 CDK98658.1 - 1.4e-07 31.1 13.9 0.00099 19.1 4.1 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4 PF00037.27 CDK98658.1 - 4.1e-07 29.5 20.0 2.9e-06 26.8 2.4 3.2 3 0 0 3 3 3 3 4Fe-4S binding domain Fer4_9 PF13187.6 CDK98658.1 - 3.7e-06 27.0 28.2 0.0009 19.4 16.8 2.0 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDK98658.1 - 1.2e-05 25.8 15.7 3.8e-05 24.2 15.8 1.8 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDK98658.1 - 7.9e-05 23.5 13.7 0.00037 21.4 6.1 2.2 1 1 1 2 2 2 1 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 CDK98658.1 - 8.2e-05 22.6 16.0 0.0021 18.1 14.4 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDK98658.1 - 0.0015 18.6 20.2 0.0018 18.4 4.8 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK98658.1 - 0.0016 18.5 18.2 0.0031 17.5 3.1 2.4 2 1 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CDK98658.1 - 0.0018 18.6 2.6 0.0018 18.6 2.6 2.8 2 1 0 2 2 2 1 4Fe-4S binding domain Fer4_3 PF12798.7 CDK98658.1 - 0.034 15.1 20.8 0.038 14.9 5.5 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain GF_recep_IV PF14843.6 CDK98658.1 - 0.075 12.8 11.9 0.14 11.9 11.9 1.5 1 1 0 1 1 1 0 Growth factor receptor domain IV Fer4_18 PF13746.6 CDK98658.1 - 0.098 12.9 13.9 0.47 10.7 13.9 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDK98658.1 - 0.11 13.0 4.9 0.11 13.0 4.9 2.4 1 1 2 3 3 2 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDK98658.1 - 0.13 12.9 3.9 0.13 12.9 3.9 2.5 1 1 2 3 3 3 0 4Fe-4S dicluster domain Peptidase_M61 PF05299.12 CDK98660.1 - 0.12 12.8 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 M61 glycyl aminopeptidase DUF4010 PF13194.6 CDK98661.1 - 6.4e-63 212.2 24.0 6.4e-63 212.2 24.0 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF4010) MgtC PF02308.16 CDK98661.1 - 2.5e-17 63.4 7.8 2.5e-17 63.4 7.8 3.8 2 1 1 3 3 3 1 MgtC family DUF3021 PF11457.8 CDK98661.1 - 0.68 10.3 0.0 0.68 10.3 0.0 4.5 2 1 1 4 4 4 0 Protein of unknown function (DUF3021) Rubrerythrin PF02915.17 CDK98662.1 - 1.2e-14 54.8 0.0 1.1e-07 32.3 0.0 2.0 2 0 0 2 2 2 2 Rubrerythrin Ferritin PF00210.24 CDK98662.1 - 7.1e-07 29.3 0.3 2.9e-06 27.3 0.3 1.8 1 1 0 1 1 1 1 Ferritin-like domain Ferritin_2 PF13668.6 CDK98662.1 - 0.00086 19.5 2.2 0.029 14.6 2.1 2.1 1 1 0 1 1 1 1 Ferritin-like domain HATPase_c PF02518.26 CDK98663.1 - 8.6e-16 58.4 0.0 2e-15 57.3 0.0 1.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_4 PF08448.10 CDK98663.1 - 1.6e-08 34.7 1.0 5.5e-08 33.0 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CDK98663.1 - 0.00011 22.4 0.0 0.00029 21.0 0.0 1.7 1 0 0 1 1 1 1 PAS domain HATPase_c_2 PF13581.6 CDK98663.1 - 0.00096 19.1 0.0 0.0026 17.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain PAS_8 PF13188.7 CDK98663.1 - 0.0037 17.3 0.0 0.01 15.8 0.0 1.7 1 0 0 1 1 1 1 PAS domain HATPase_c_5 PF14501.6 CDK98663.1 - 0.013 15.4 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 GHKL domain PAS PF00989.25 CDK98663.1 - 0.016 15.2 0.0 0.041 13.9 0.0 1.7 1 0 0 1 1 1 0 PAS fold PorA PF11271.8 CDK98663.1 - 0.17 11.2 1.1 0.3 10.4 0.0 1.9 2 1 1 3 3 3 0 Porin PorA BatD PF13584.6 CDK98663.1 - 0.36 9.6 0.5 4.7 5.9 0.3 2.0 2 0 0 2 2 2 0 Oxygen tolerance Response_reg PF00072.24 CDK98664.1 - 2e-23 82.7 0.1 2.4e-23 82.4 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain PQ-loop PF04193.14 CDK98665.1 - 7.3e-09 35.3 0.3 1.1e-08 34.7 0.3 1.3 1 0 0 1 1 1 1 PQ loop repeat MtN3_slv PF03083.16 CDK98665.1 - 1.4e-06 28.3 0.4 1.5e-06 28.2 0.4 1.1 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange Imp-YgjV PF10688.9 CDK98665.1 - 0.0023 17.8 5.1 0.003 17.4 5.1 1.3 1 1 0 1 1 1 1 Bacterial inner membrane protein LAB_N PF07578.11 CDK98665.1 - 0.0073 16.4 1.4 0.0086 16.1 1.4 1.1 1 0 0 1 1 1 1 Lipid A Biosynthesis N-terminal domain SLATT_1 PF18181.1 CDK98665.1 - 0.012 15.5 1.1 0.015 15.2 1.1 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 DUF2919 PF11143.8 CDK98665.1 - 0.015 15.6 1.3 0.018 15.4 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2919) DUF3040 PF11239.8 CDK98665.1 - 0.036 14.4 4.8 0.049 13.9 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF2244 PF10003.9 CDK98665.1 - 0.059 13.0 0.8 0.08 12.6 0.8 1.2 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) DUF4191 PF13829.6 CDK98665.1 - 0.078 12.3 1.4 0.092 12.1 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) MgtC PF02308.16 CDK98665.1 - 0.1 13.0 5.8 0.17 12.3 5.8 1.3 1 0 0 1 1 1 0 MgtC family LrgA PF03788.14 CDK98666.1 - 6.1e-29 99.8 7.0 7.9e-29 99.5 7.0 1.2 1 0 0 1 1 1 1 LrgA family LrgB PF04172.16 CDK98667.1 - 1.1e-81 273.4 16.9 1.3e-81 273.2 16.9 1.0 1 0 0 1 1 1 1 LrgB-like family CPP1-like PF11833.8 CDK98667.1 - 6.4 6.4 7.9 6.8 6.3 6.3 2.0 1 1 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Fumerase_C PF05683.12 CDK98668.1 - 2.2e-89 298.2 0.0 3.9e-89 297.4 0.0 1.4 1 0 0 1 1 1 1 Fumarase C-terminus Fumerase PF05681.14 CDK98668.1 - 1.5e-86 290.2 0.0 1.9e-86 289.9 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Colipase_C PF02740.14 CDK98668.1 - 0.12 12.6 0.9 0.19 11.9 0.1 1.7 2 0 0 2 2 2 0 Colipase, C-terminal domain SspB PF04386.13 CDK98669.1 - 1.1e-46 158.6 0.0 1.4e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Stringent starvation protein B LysR_substrate PF03466.20 CDK98670.1 - 5.8e-33 114.0 2.7 5.8e-33 114.0 2.7 1.5 2 0 0 2 2 2 1 LysR substrate binding domain HTH_1 PF00126.27 CDK98670.1 - 8.7e-19 67.2 1.5 2.1e-18 66.0 1.5 1.7 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_20 PF12840.7 CDK98670.1 - 0.013 15.5 0.0 0.043 13.9 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.6 CDK98670.1 - 0.029 13.9 0.2 0.08 12.5 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 CDK98670.1 - 0.057 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_30 PF13556.6 CDK98670.1 - 0.12 12.1 0.3 0.33 10.8 0.3 1.8 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Sbt_1 PF05982.12 CDK98672.1 - 1.6e-107 359.3 28.2 1.8e-107 359.2 28.2 1.0 1 0 0 1 1 1 1 Na+-dependent bicarbonate transporter superfamily ParA PF10609.9 CDK98674.1 - 3.4e-107 357.5 0.1 4.2e-107 357.2 0.1 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase FeS_assembly_P PF01883.19 CDK98674.1 - 8.1e-17 61.2 1.0 2.1e-16 59.8 1.0 1.7 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein CbiA PF01656.23 CDK98674.1 - 7.3e-16 58.4 0.0 1.3e-15 57.5 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDK98674.1 - 2.7e-10 40.4 0.4 3.2e-09 37.0 0.1 2.1 2 0 0 2 2 2 1 AAA domain Fer4_NifH PF00142.18 CDK98674.1 - 2.2e-09 37.2 0.0 0.00026 20.5 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 CDK98674.1 - 4.2e-08 32.8 0.0 7.7e-08 31.9 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 CDK98674.1 - 3.4e-06 26.5 1.9 0.00016 21.0 0.8 2.8 2 1 1 3 3 3 1 Anion-transporting ATPase VirC1 PF07015.11 CDK98674.1 - 0.00025 20.4 0.1 0.00048 19.5 0.1 1.4 1 0 0 1 1 1 1 VirC1 protein SRP54 PF00448.22 CDK98674.1 - 0.0022 17.6 0.1 0.0041 16.8 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_26 PF13500.6 CDK98674.1 - 0.008 16.0 1.0 0.86 9.4 0.3 2.6 2 1 0 3 3 3 1 AAA domain AAA_25 PF13481.6 CDK98674.1 - 0.0089 15.6 0.4 0.053 13.1 0.1 2.1 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 CDK98674.1 - 0.019 14.0 0.1 0.035 13.1 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CLP1_P PF16575.5 CDK98674.1 - 0.064 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop APS_kinase PF01583.20 CDK98674.1 - 0.094 12.6 0.0 0.28 11.1 0.0 1.7 2 0 0 2 2 2 0 Adenylylsulphate kinase A2L_zn_ribbon PF08792.10 CDK98674.1 - 0.16 11.7 0.1 0.3 10.9 0.1 1.4 1 0 0 1 1 1 0 A2L zinc ribbon domain Band_7 PF01145.25 CDK98676.1 - 9e-23 81.2 0.9 9e-23 81.2 0.9 1.5 2 0 0 2 2 2 1 SPFH domain / Band 7 family HflK_N PF12221.8 CDK98676.1 - 1e-08 35.0 35.0 5.8e-08 32.6 12.8 2.6 1 1 1 2 2 2 2 Bacterial membrane protein N terminal DUF349 PF03993.12 CDK98676.1 - 0.15 12.4 5.0 0.54 10.6 5.0 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF349) Flot PF15975.5 CDK98676.1 - 0.25 11.6 0.2 0.25 11.6 0.2 2.6 3 0 0 3 3 3 0 Flotillin DivIVA PF05103.13 CDK98676.1 - 0.29 11.2 6.2 0.095 12.8 0.8 2.1 1 1 1 2 2 2 0 DivIVA protein V-ATPase_G_2 PF16999.5 CDK98676.1 - 3.1 8.3 11.0 0.21 12.0 2.5 2.5 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit Band_7 PF01145.25 CDK98677.1 - 3.1e-28 99.0 0.6 3.1e-28 99.0 0.6 1.4 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 CDK98677.1 - 0.014 15.2 0.1 0.025 14.3 0.1 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family DUF4417 PF14386.6 CDK98677.1 - 0.074 12.6 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) DNMT1-RFD PF12047.8 CDK98677.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Cytosine specific DNA methyltransferase replication foci domain Flot PF15975.5 CDK98677.1 - 0.23 11.7 2.4 7 6.9 1.6 2.3 2 0 0 2 2 2 0 Flotillin DUF2065 PF09838.9 CDK98678.1 - 7.4e-18 64.3 6.2 8.4e-18 64.1 6.2 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2065) Trypsin_2 PF13365.6 CDK98679.1 - 2.8e-34 119.2 1.7 2.8e-34 119.2 1.7 2.1 2 1 0 2 2 2 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 CDK98679.1 - 5.3e-28 97.2 1.0 2.2e-17 63.1 0.0 2.8 3 0 0 3 3 3 2 PDZ domain PDZ PF00595.24 CDK98679.1 - 5.5e-22 77.9 0.0 3.7e-11 43.2 0.0 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 CDK98679.1 - 3.4e-19 68.4 3.4 1.4e-08 34.4 0.0 3.3 4 0 0 4 4 4 2 PDZ domain Trypsin PF00089.26 CDK98679.1 - 1.6e-16 60.8 0.0 2.9e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin Peptidase_S29 PF02907.15 CDK98679.1 - 0.003 17.3 0.0 0.033 13.9 0.0 2.4 2 1 1 3 3 3 1 Hepatitis C virus NS3 protease Peptidase_S46 PF10459.9 CDK98679.1 - 0.0033 16.1 0.2 0.043 12.5 0.3 2.0 2 0 0 2 2 2 1 Peptidase S46 Tricorn_PDZ PF14685.6 CDK98679.1 - 0.028 14.4 0.1 6.2 6.9 0.0 2.7 2 0 0 2 2 2 0 Tricorn protease PDZ domain Peptidase_S32 PF05579.13 CDK98679.1 - 0.23 10.6 1.5 8.6 5.4 0.0 2.2 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Peptidase_S7 PF00949.21 CDK98679.1 - 0.25 11.1 0.5 0.53 10.1 0.5 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease AMP-binding PF00501.28 CDK98680.1 - 2.5e-83 280.1 0.3 3.5e-83 279.5 0.3 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CDK98680.1 - 1.2e-24 86.0 3.1 1.2e-24 86.0 3.1 2.0 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 CDK98680.1 - 1.2e-22 80.6 0.9 1.2e-22 80.6 0.9 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Flavoprotein PF02441.19 CDK98682.1 - 6.2e-23 81.3 0.1 7.8e-23 81.0 0.1 1.1 1 0 0 1 1 1 1 Flavoprotein PNP_UDP_1 PF01048.20 CDK98682.1 - 0.041 13.1 0.1 0.065 12.5 0.1 1.3 1 0 0 1 1 1 0 Phosphorylase superfamily DUF3875 PF12991.7 CDK98682.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3875) PFK PF00365.20 CDK98683.1 - 1.7e-93 313.1 0.6 1.9e-93 312.9 0.6 1.0 1 0 0 1 1 1 1 Phosphofructokinase NAD_kinase PF01513.21 CDK98683.1 - 0.00016 21.0 0.0 0.00027 20.2 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 CDK98683.1 - 0.0034 17.0 0.2 0.015 14.9 0.1 2.1 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain DUF465 PF04325.13 CDK98684.1 - 4.2e-14 52.3 6.1 4.2e-14 52.3 6.1 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF465) WASH_WAHD PF11945.8 CDK98684.1 - 0.04 13.4 3.1 0.049 13.2 3.1 1.0 1 0 0 1 1 1 0 WAHD domain of WASH complex Syntaxin-6_N PF09177.11 CDK98684.1 - 0.059 13.9 1.8 0.063 13.8 1.8 1.1 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DivIC PF04977.15 CDK98684.1 - 0.11 12.3 9.0 1.6 8.5 3.6 2.0 1 1 1 2 2 2 0 Septum formation initiator Fib_alpha PF08702.10 CDK98684.1 - 0.18 12.0 2.8 0.29 11.3 2.8 1.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FapA PF03961.13 CDK98684.1 - 0.26 9.8 3.4 0.28 9.7 3.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prefoldin PF02996.17 CDK98684.1 - 0.34 10.8 4.8 0.78 9.7 0.2 2.0 1 1 0 2 2 2 0 Prefoldin subunit DUF1492 PF07374.11 CDK98684.1 - 0.66 10.2 3.3 7.8 6.7 0.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1492) Prefoldin_2 PF01920.20 CDK98684.1 - 0.78 9.7 9.4 6.6 6.7 5.3 2.0 2 0 0 2 2 2 0 Prefoldin subunit DUF4140 PF13600.6 CDK98684.1 - 1.1 9.8 6.1 7.1 7.1 1.3 2.0 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) SlyX PF04102.12 CDK98684.1 - 4 8.1 8.9 38 5.0 8.9 2.0 1 1 0 1 1 1 0 SlyX MFS_1 PF07690.16 CDK98685.1 - 5.5e-37 127.5 44.2 5.5e-37 127.5 44.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CDK98685.1 - 8e-05 21.7 6.5 8e-05 21.7 6.5 3.9 1 1 3 5 5 5 2 Sugar (and other) transporter MFS_4 PF06779.14 CDK98685.1 - 0.00024 20.5 1.4 0.00024 20.5 1.4 3.5 2 2 1 3 3 3 2 Uncharacterised MFS-type transporter YbfB Rick_17kDa_Anti PF05433.15 CDK98685.1 - 0.12 12.3 6.5 1.7 8.5 0.0 4.2 4 0 0 4 4 4 0 Glycine zipper 2TM domain GGDEF PF00990.21 CDK98686.1 - 3.9e-06 26.7 0.0 5.7e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain AIRC PF00731.20 CDK98687.1 - 6e-63 210.9 0.5 7e-63 210.6 0.5 1.0 1 0 0 1 1 1 1 AIR carboxylase Fes1 PF08609.10 CDK98687.1 - 0.074 13.9 0.0 0.23 12.4 0.0 1.7 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 ATP-grasp PF02222.22 CDK98688.1 - 3.4e-52 176.5 0.0 4.8e-52 176.0 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 CDK98688.1 - 1.1e-16 60.3 0.0 2.2e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 CDK98688.1 - 4.3e-05 23.1 0.0 0.00023 20.8 0.0 2.0 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus PALP PF00291.25 CDK98688.1 - 0.00021 20.8 0.6 0.00064 19.2 0.1 1.9 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme 2-Hacid_dh_C PF02826.19 CDK98688.1 - 0.00046 19.6 0.0 0.00099 18.5 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 CDK98688.1 - 0.0014 17.8 0.2 0.0019 17.4 0.2 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_2 PF03446.15 CDK98688.1 - 0.0029 17.8 0.0 0.0053 16.9 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CDK98688.1 - 0.01 15.7 0.1 0.017 15.0 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 CDK98688.1 - 0.01 15.1 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDK98688.1 - 0.013 16.1 0.1 0.054 14.1 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.17 CDK98688.1 - 0.018 15.6 0.1 0.038 14.6 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.21 CDK98688.1 - 0.027 13.8 0.1 0.051 12.9 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GARS_A PF01071.19 CDK98688.1 - 0.05 13.4 0.0 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain FAD_oxidored PF12831.7 CDK98688.1 - 0.062 12.6 0.5 0.099 12.0 0.5 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Glyco_transf_4 PF13439.6 CDK98688.1 - 0.094 12.7 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase Family 4 CBS PF00571.28 CDK98689.1 - 7.3e-22 77.6 0.6 1.5e-09 38.1 0.0 2.2 2 0 0 2 2 2 2 CBS domain GAF_2 PF13185.6 CDK98689.1 - 0.015 15.6 0.1 0.024 14.9 0.1 1.3 1 1 0 1 1 1 0 GAF domain SNARE_assoc PF09335.11 CDK98690.1 - 1.6e-12 48.0 6.2 1.6e-12 48.0 6.2 2.5 2 1 1 3 3 3 1 SNARE associated Golgi protein DUF4307 PF14155.6 CDK98690.1 - 0.29 11.0 2.4 3.7 7.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) SLT PF01464.20 CDK98691.1 - 5.4e-05 22.8 0.0 0.00015 21.4 0.0 1.8 1 1 0 1 1 1 1 Transglycosylase SLT domain DUF2188 PF09954.9 CDK98691.1 - 0.024 14.7 1.6 0.028 14.5 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) DUF3987 PF13148.6 CDK98691.1 - 0.11 11.5 4.1 0.15 11.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) DNA_gyraseA_C PF03989.13 CDK98691.1 - 0.21 11.1 0.1 0.47 10.0 0.1 1.6 1 0 0 1 1 1 0 DNA gyrase C-terminal domain, beta-propeller BLUF PF04940.12 CDK98692.1 - 9.3e-32 109.0 0.1 1.7e-31 108.2 0.1 1.4 1 0 0 1 1 1 1 Sensors of blue-light using FAD Flavodoxin_2 PF02525.17 CDK98692.1 - 0.11 12.3 0.1 0.66 9.6 0.0 1.9 2 0 0 2 2 2 0 Flavodoxin-like fold HTH_Tnp_IS630 PF01710.16 CDK98693.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK98693.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK98693.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK98693.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK98693.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK98693.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDK98694.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK98694.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain YceG PF02618.16 CDK98696.1 - 2.2e-79 266.9 0.0 2.5e-79 266.7 0.0 1.0 1 0 0 1 1 1 1 YceG-like family ketoacyl-synt PF00109.26 CDK98697.1 - 1.4e-63 214.8 1.0 1.4e-63 214.8 1.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CDK98697.1 - 2.4e-36 124.3 0.3 4.3e-36 123.5 0.3 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CDK98697.1 - 6.2e-07 29.0 0.9 2.3e-05 23.9 0.6 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDK98697.1 - 0.00019 21.1 1.4 0.00072 19.2 0.2 2.3 2 0 0 2 2 2 1 Thiolase, C-terminal domain KAsynt_C_assoc PF16197.5 CDK98697.1 - 0.0091 16.4 0.0 0.022 15.2 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 CDK98698.1 - 3.3e-13 49.8 0.3 3.6e-13 49.7 0.3 1.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CDK98698.1 - 0.00014 22.0 0.7 0.00015 21.9 0.7 1.2 1 0 0 1 1 1 1 Acyl-carrier Ribosomal_L12_N PF16320.5 CDK98698.1 - 0.022 14.5 1.6 0.065 13.0 0.3 2.4 2 1 1 3 3 3 0 Ribosomal protein L7/L12 dimerisation domain Ribosomal_L50 PF10501.9 CDK98698.1 - 0.062 13.4 0.0 0.085 13.0 0.0 1.5 1 1 0 1 1 1 0 Ribosomal subunit 39S DUF1493 PF07377.12 CDK98698.1 - 0.086 13.3 0.1 0.091 13.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) adh_short_C2 PF13561.6 CDK98699.1 - 8.9e-70 234.9 8.6 1e-69 234.7 8.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDK98699.1 - 8.6e-64 214.6 3.5 1.1e-63 214.3 3.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDK98699.1 - 5.6e-20 72.0 1.3 7.6e-20 71.6 1.3 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CDK98699.1 - 3.5e-07 30.3 2.8 4.5e-07 29.9 2.8 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CDK98699.1 - 9.6e-05 22.0 0.3 0.0002 20.9 0.3 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 CDK98699.1 - 0.0017 17.7 0.1 0.0053 16.1 0.0 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_Gly3P_dh_N PF01210.23 CDK98699.1 - 0.003 17.6 0.8 0.015 15.3 0.8 2.0 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 CDK98699.1 - 0.0081 16.7 3.0 1.8 9.2 1.0 2.7 2 1 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 CDK98699.1 - 0.02 14.4 1.1 0.049 13.2 0.3 1.8 2 0 0 2 2 2 0 NmrA-like family RmlD_sub_bind PF04321.17 CDK98699.1 - 0.031 13.4 2.2 0.06 12.4 0.2 2.1 2 1 0 2 2 2 0 RmlD substrate binding domain 3HCDH_N PF02737.18 CDK98699.1 - 0.059 13.3 3.5 0.15 11.9 0.3 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ParD_antitoxin PF03693.14 CDK98699.1 - 0.065 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH 2-Hacid_dh_C PF02826.19 CDK98699.1 - 0.085 12.2 0.7 0.22 10.8 0.7 1.8 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 CDK98699.1 - 0.1 12.7 0.3 0.1 12.7 0.3 2.2 2 1 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain DFP PF04127.15 CDK98699.1 - 0.62 9.9 4.3 0.36 10.6 0.3 2.3 2 1 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein Acyl_transf_1 PF00698.21 CDK98700.1 - 1.3e-38 133.3 7.9 1.6e-38 133.0 7.9 1.0 1 0 0 1 1 1 1 Acyl transferase domain EII-GUT PF03608.13 CDK98700.1 - 0.012 15.6 0.0 0.58 10.0 0.0 2.2 2 0 0 2 2 2 0 PTS system enzyme II sorbitol-specific factor LPD7 PF18821.1 CDK98700.1 - 0.052 13.7 0.3 0.13 12.4 0.3 1.7 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 7 Hemerythrin PF01814.23 CDK98701.1 - 4.4e-05 24.1 2.9 5.1e-05 23.9 2.9 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Ribosomal_S6 PF01250.17 CDK98702.1 - 1.2e-24 86.3 0.0 1.5e-24 86.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 Ribosomal_S18 PF01084.20 CDK98703.1 - 6e-26 90.4 0.1 7.6e-26 90.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S18 DUF2232 PF09991.9 CDK98704.1 - 4.1e-07 29.5 35.1 9.9e-06 24.9 35.1 2.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2232) LMBR1 PF04791.16 CDK98704.1 - 8.1 5.2 7.2 1.5 7.6 0.5 2.3 2 1 0 2 2 2 0 LMBR1-like membrane protein Ribosomal_L9_C PF03948.14 CDK98705.1 - 5.3e-26 90.9 0.0 5.3e-26 90.9 0.0 2.0 3 0 0 3 3 3 1 Ribosomal protein L9, C-terminal domain Ribosomal_L9_N PF01281.19 CDK98705.1 - 5e-22 77.2 0.3 9e-22 76.4 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Ribosomal_60s PF00428.19 CDK98705.1 - 5 7.8 20.4 62 4.3 20.4 2.2 1 1 0 1 1 1 0 60s Acidic ribosomal protein CMAS PF02353.20 CDK98706.1 - 3.2e-90 302.2 0.0 4.1e-90 301.8 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CDK98706.1 - 7.1e-18 65.1 0.0 1.6e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK98706.1 - 1.8e-13 50.9 0.1 3.6e-13 50.0 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDK98706.1 - 1.9e-13 50.5 0.0 3e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK98706.1 - 5.3e-12 46.4 0.0 1.3e-11 45.1 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDK98706.1 - 2.1e-11 43.9 0.0 3.3e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDK98706.1 - 2.4e-06 27.2 0.0 3.9e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CDK98706.1 - 4.2e-05 23.0 0.0 8.5e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 CDK98706.1 - 0.00044 19.7 0.1 0.00081 18.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 CDK98706.1 - 0.00052 20.0 0.0 0.00085 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDK98706.1 - 0.001 19.0 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDK98706.1 - 0.0034 17.2 0.0 0.0056 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 CDK98706.1 - 0.0058 15.6 0.0 0.01 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Met_10 PF02475.16 CDK98706.1 - 0.0067 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.18 CDK98706.1 - 0.0069 16.1 0.1 0.017 14.8 0.0 1.5 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_3 PF01596.17 CDK98706.1 - 0.019 14.1 0.0 0.03 13.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_4 PF02390.17 CDK98706.1 - 0.021 14.3 0.0 0.044 13.3 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_24 PF13578.6 CDK98706.1 - 0.028 15.5 0.1 0.099 13.7 0.1 2.0 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 CDK98706.1 - 0.039 13.5 0.1 0.063 12.9 0.1 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_15 PF09445.10 CDK98706.1 - 0.047 13.3 0.0 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase ADH_zinc_N PF00107.26 CDK98706.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase GCD14 PF08704.10 CDK98706.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_16 PF10294.9 CDK98706.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase EAL PF00563.20 CDK98707.1 - 0.011 15.2 0.0 0.063 12.8 0.0 2.2 2 1 0 2 2 2 0 EAL domain DnaB_C PF03796.15 CDK98708.1 - 4.9e-106 353.8 0.0 6.3e-106 353.4 0.0 1.1 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain DnaB PF00772.21 CDK98708.1 - 8.5e-30 102.9 0.0 1.6e-29 102.0 0.0 1.5 1 0 0 1 1 1 1 DnaB-like helicase N terminal domain AAA_25 PF13481.6 CDK98708.1 - 2e-13 50.4 0.2 3.4e-13 49.6 0.2 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CDK98708.1 - 0.0019 17.6 0.0 0.0035 16.7 0.0 1.7 1 1 0 1 1 1 1 KaiC AAA_16 PF13191.6 CDK98708.1 - 0.014 15.8 1.7 0.049 14.0 0.3 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 CDK98708.1 - 0.048 14.1 0.2 0.21 12.0 0.2 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDK98708.1 - 0.05 13.9 0.1 0.13 12.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain Ala_racemase_N PF01168.20 CDK98709.1 - 6e-59 199.3 0.0 7.4e-59 199.0 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ala_racemase_C PF00842.21 CDK98709.1 - 4e-33 113.9 0.1 7.5e-33 113.0 0.1 1.5 1 0 0 1 1 1 1 Alanine racemase, C-terminal domain MlaE PF02405.16 CDK98710.1 - 8.4e-81 270.7 20.1 1.1e-80 270.3 20.1 1.1 1 0 0 1 1 1 1 Permease MlaE ABC_tran PF00005.27 CDK98711.1 - 1.9e-29 102.9 0.0 2.4e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98711.1 - 2.4e-08 34.2 0.2 0.0003 20.7 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_19 PF13245.6 CDK98711.1 - 0.00032 21.1 0.0 0.00048 20.5 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDK98711.1 - 0.00036 20.2 0.3 0.00065 19.4 0.3 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDK98711.1 - 0.0015 18.9 0.2 0.0024 18.3 0.2 1.4 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 CDK98711.1 - 0.0019 17.6 0.3 0.02 14.3 0.1 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CDK98711.1 - 0.0067 16.0 0.1 0.011 15.3 0.1 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region ATP-synt_ab PF00006.25 CDK98711.1 - 0.0089 15.7 0.1 0.012 15.2 0.1 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain SMC_N PF02463.19 CDK98711.1 - 0.009 15.5 0.7 0.22 11.0 0.7 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 CDK98711.1 - 0.0091 15.7 0.2 0.014 15.1 0.2 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CDK98711.1 - 0.015 15.7 0.4 0.2 12.1 0.4 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDK98711.1 - 0.038 14.2 0.0 0.083 13.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 CDK98711.1 - 0.04 13.8 0.6 0.065 13.1 0.6 1.3 1 0 0 1 1 1 0 RsgA GTPase T2SSE PF00437.20 CDK98711.1 - 0.053 12.6 0.1 0.087 11.9 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.6 CDK98711.1 - 0.062 13.5 0.4 0.22 11.8 0.5 1.8 2 0 0 2 2 2 0 AAA domain PIF1 PF05970.14 CDK98711.1 - 0.12 11.6 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase FtsK_SpoIIIE PF01580.18 CDK98711.1 - 0.16 11.3 0.2 0.29 10.5 0.2 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family NACHT PF05729.12 CDK98711.1 - 0.17 11.8 0.2 0.36 10.7 0.2 1.5 1 0 0 1 1 1 0 NACHT domain Pox_A32 PF04665.12 CDK98711.1 - 0.22 11.0 0.1 0.34 10.3 0.1 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein DUF2075 PF09848.9 CDK98711.1 - 0.4 9.9 0.7 0.54 9.4 0.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SBP_bac_3 PF00497.20 CDK98712.1 - 4e-10 39.5 0.0 6.1e-10 38.9 0.0 1.3 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 RsdA_SigD_bd PF16751.5 CDK98712.1 - 0.016 15.4 0.8 0.71 10.2 0.1 2.4 2 0 0 2 2 2 0 Anti-sigma-D factor RsdA to sigma factor binding region HATPase_c PF02518.26 CDK98713.1 - 2.5e-16 60.2 0.0 4.4e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CHASE5 PF17149.4 CDK98713.1 - 4.7e-09 36.1 0.0 1.4e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Periplasmic sensor domain found in signal transduction proteins PAS_4 PF08448.10 CDK98713.1 - 6.2e-05 23.2 0.3 0.00016 21.9 0.3 1.7 1 0 0 1 1 1 1 PAS fold HAMP PF00672.25 CDK98713.1 - 8.4e-05 22.9 0.2 0.00026 21.3 0.2 1.9 1 0 0 1 1 1 1 HAMP domain HisKA PF00512.25 CDK98713.1 - 0.00026 21.0 0.6 0.0017 18.4 0.1 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 CDK98713.1 - 0.001 19.1 0.1 0.005 16.8 0.1 2.3 1 1 0 1 1 1 1 PAS domain PAS_9 PF13426.7 CDK98713.1 - 0.21 11.9 0.0 0.52 10.6 0.0 1.7 1 0 0 1 1 1 0 PAS domain ATPase PF06745.13 CDK98714.1 - 2.4e-15 56.5 0.1 5.4e-09 35.7 0.0 2.2 1 1 1 2 2 2 2 KaiC AAA_25 PF13481.6 CDK98714.1 - 3.2e-14 52.9 1.9 9.5e-14 51.4 1.9 1.7 1 1 0 1 1 1 1 AAA domain Rubredoxin_2 PF18073.1 CDK98714.1 - 4e-11 42.4 3.7 6.7e-11 41.7 3.7 1.4 1 0 0 1 1 1 1 Rubredoxin metal binding domain ChlI PF13541.6 CDK98714.1 - 4e-08 33.1 0.1 8.7e-08 32.0 0.1 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 CDK98714.1 - 4.7e-07 30.3 0.7 1.4e-06 28.8 0.7 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CDK98714.1 - 1.5e-05 25.4 0.0 2.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 CDK98714.1 - 4.3e-05 23.0 0.0 0.00084 18.7 0.0 2.1 1 1 1 2 2 2 1 DnaB-like helicase C terminal domain Lon_C PF05362.13 CDK98714.1 - 0.00017 21.2 0.2 0.00031 20.3 0.2 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain GvpD PF07088.11 CDK98714.1 - 0.00026 19.7 0.1 0.039 12.6 0.0 2.1 2 0 0 2 2 2 2 GvpD gas vesicle protein AAA_22 PF13401.6 CDK98714.1 - 0.00037 20.8 0.0 0.0013 19.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 CDK98714.1 - 0.0021 17.8 0.0 0.0076 16.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 CDK98714.1 - 0.0068 16.3 0.3 0.047 13.6 0.0 2.3 1 1 0 2 2 2 1 NTPase Zeta_toxin PF06414.12 CDK98714.1 - 0.018 14.3 0.1 0.036 13.3 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_5 PF07728.14 CDK98714.1 - 0.018 15.0 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Rad51 PF08423.11 CDK98714.1 - 0.022 14.0 0.1 0.077 12.2 0.1 2.0 1 1 0 1 1 1 0 Rad51 AAA_14 PF13173.6 CDK98714.1 - 0.027 14.5 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CDK98714.1 - 0.096 11.9 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MCM PF00493.23 CDK98714.1 - 0.14 11.2 0.0 0.26 10.3 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_30 PF13604.6 CDK98714.1 - 0.16 11.7 2.7 0.62 9.7 2.7 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CDK98714.1 - 0.17 11.8 0.1 0.27 11.1 0.1 1.4 1 1 0 1 1 1 0 NACHT domain DAP3 PF10236.9 CDK98714.1 - 0.35 10.0 0.6 0.68 9.1 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF1258 PF06869.12 CDK98714.1 - 0.76 9.2 1.8 3.3 7.1 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1258) Colicin_V PF02674.16 CDK98715.1 - 8.2e-31 106.9 11.7 1.1e-30 106.5 11.7 1.1 1 0 0 1 1 1 1 Colicin V production protein GATase_6 PF13522.6 CDK98716.1 - 2e-18 66.9 0.0 4.3e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CDK98716.1 - 2.1e-18 66.4 0.0 4.4e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 CDK98716.1 - 2.3e-09 36.9 0.2 4.5e-09 36.0 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 CDK98716.1 - 1.3e-05 24.3 0.0 2.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferases class-II PRTase_2 PF15609.6 CDK98716.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase EIF_2_alpha PF07541.12 CDK98716.1 - 0.21 11.7 0.0 0.37 10.9 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit adh_short PF00106.25 CDK98717.1 - 2.2e-47 161.0 0.1 2.6e-47 160.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDK98717.1 - 8.4e-38 130.2 1.8 1.1e-37 129.9 1.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDK98717.1 - 1.8e-08 34.5 0.2 2.5e-08 34.0 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CDK98717.1 - 3.9e-05 23.2 0.6 0.00026 20.6 0.6 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 CDK98717.1 - 0.01 15.2 0.2 0.022 14.1 0.2 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 CDK98717.1 - 0.017 15.0 0.1 0.036 13.9 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H-binding DUF1776 PF08643.10 CDK98717.1 - 0.09 12.1 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DD_K PF12121.8 CDK98717.1 - 0.18 11.9 2.7 1.8 8.7 0.1 2.9 2 0 0 2 2 2 0 Dermaseptin Trypsin PF00089.26 CDK98721.1 - 3.9e-16 59.5 0.0 4.8e-15 56.0 0.0 1.9 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDK98721.1 - 2.6e-09 38.2 0.0 4.2e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Mito_fiss_Elm1 PF06258.11 CDK98722.1 - 2.4e-88 296.2 0.0 2.7e-88 296.1 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial fission ELM1 ECH_1 PF00378.20 CDK98723.1 - 3.2e-49 167.5 0.0 3.6e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDK98723.1 - 1.5e-20 74.0 0.0 1.9e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Pribosyltran PF00156.27 CDK98724.1 - 1.9e-11 43.7 0.0 2.8e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Acetyltransf_4 PF13420.7 CDK98726.1 - 1.1e-27 97.1 0.0 1.3e-27 96.9 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDK98726.1 - 8.3e-17 61.5 0.0 1.1e-16 61.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDK98726.1 - 6.2e-09 36.2 0.0 9.4e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CDK98726.1 - 2.1e-08 34.9 0.0 2.7e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDK98726.1 - 1.2e-07 31.7 0.0 1.8e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDK98726.1 - 0.00021 21.2 0.0 0.00032 20.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CDK98726.1 - 0.0017 18.5 0.0 0.0041 17.2 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 CDK98726.1 - 0.014 15.6 0.1 0.02 15.0 0.1 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 CDK98726.1 - 0.052 13.1 0.0 0.074 12.6 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase Acetyltransf_CG PF14542.6 CDK98726.1 - 0.074 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Gly_kinase PF02595.15 CDK98726.1 - 0.12 11.3 0.5 0.18 10.8 0.5 1.1 1 0 0 1 1 1 0 Glycerate kinase family FGase PF05013.12 CDK98727.1 - 3.6e-72 243.1 0.1 4.3e-72 242.8 0.1 1.0 1 0 0 1 1 1 1 N-formylglutamate amidohydrolase Hexapep_2 PF14602.6 CDK98727.1 - 0.032 14.0 1.0 0.063 13.0 1.0 1.5 1 0 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase DDE_Tnp_IS66 PF03050.14 CDK98728.1 - 2.9e-89 299.3 0.4 4.9e-89 298.6 0.0 1.6 2 0 0 2 2 2 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK98728.1 - 2.9e-18 65.8 0.0 1e-17 64.0 0.0 2.0 1 0 0 1 1 1 1 IS66 C-terminal element LZ_Tnp_IS66 PF13007.7 CDK98728.1 - 3e-16 59.9 4.3 3e-16 59.9 4.3 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDK98728.1 - 1.5e-15 57.3 4.6 2.9e-15 56.4 4.6 1.5 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDK98728.1 - 0.18 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.12 CDK98728.1 - 1.1 10.0 3.9 11 6.8 2.2 2.9 2 1 1 3 3 3 0 SlyX TnpB_IS66 PF05717.13 CDK98729.1 - 9.3e-38 128.2 0.0 1e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein HTH_Tnp_1 PF01527.20 CDK98730.1 - 2.4e-16 59.8 0.3 3.3e-16 59.4 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDK98730.1 - 3.3e-06 26.7 0.0 5.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 CDK98730.1 - 0.0068 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 CDK98730.1 - 0.017 15.2 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 CDK98730.1 - 0.039 13.6 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HATPase_c PF02518.26 CDK98731.1 - 1.9e-24 86.3 0.0 3.7e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 CDK98731.1 - 1.1e-10 41.7 0.0 4.7e-10 39.7 0.0 1.9 2 0 0 2 2 2 1 Cache domain HisKA PF00512.25 CDK98731.1 - 5.3e-09 36.0 0.2 1.9e-08 34.2 0.1 2.1 1 1 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CDK98731.1 - 3.1e-05 23.8 0.0 5.5e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 CDK98731.1 - 0.0011 18.9 0.3 0.0058 16.6 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 CDK98731.1 - 0.014 15.3 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK98732.1 - 3.5e-26 91.6 0.4 9.1e-26 90.2 0.2 1.7 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK98732.1 - 3e-24 84.9 0.2 1.2e-22 79.8 0.1 2.4 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal MarR_2 PF12802.7 CDK98732.1 - 0.0016 18.3 1.4 0.0041 17.0 0.4 2.2 2 0 0 2 2 2 1 MarR family Response_reg PF00072.24 CDK98733.1 - 2e-42 143.9 0.3 4.6e-22 78.3 0.0 2.6 3 0 0 3 3 3 2 Response regulator receiver domain HATPase_c PF02518.26 CDK98733.1 - 1.7e-31 109.1 0.0 2.9e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98733.1 - 5.2e-18 64.8 0.1 2.8e-17 62.5 0.1 2.4 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.23 CDK98733.1 - 3.7e-08 33.5 4.3 9.2e-08 32.3 3.2 2.3 2 0 0 2 2 2 1 Hpt domain HATPase_c_3 PF13589.6 CDK98733.1 - 0.0021 17.9 0.0 0.0034 17.2 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK98734.1 - 1e-18 67.5 0.0 1.3e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 CDK98735.1 - 4.1e-23 82.0 0.0 1.4e-22 80.3 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 CDK98735.1 - 7.3e-15 55.0 0.1 3.4e-14 52.9 0.0 2.1 2 0 0 2 2 2 1 PAS fold HisKA PF00512.25 CDK98735.1 - 6.1e-13 48.6 2.5 1.5e-12 47.3 0.1 2.9 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDK98735.1 - 2.8e-06 27.6 0.8 9.3e-06 25.9 0.2 2.4 2 0 0 2 2 2 1 HAMP domain PAS_4 PF08448.10 CDK98735.1 - 7.5e-05 22.9 0.5 0.00026 21.2 0.5 2.0 1 0 0 1 1 1 1 PAS fold HATPase_c_5 PF14501.6 CDK98735.1 - 0.017 15.0 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 GHKL domain DUF4635 PF15466.6 CDK98735.1 - 0.018 14.6 0.1 0.056 13.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) PAS_9 PF13426.7 CDK98735.1 - 0.031 14.5 0.0 0.068 13.4 0.0 1.6 1 0 0 1 1 1 0 PAS domain PAS PF00989.25 CDK98735.1 - 0.074 13.0 0.2 0.25 11.4 0.1 2.0 3 0 0 3 3 3 0 PAS fold LapA_dom PF06305.11 CDK98735.1 - 4.2 7.3 5.9 9.7 6.1 0.7 2.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain NUDIX PF00293.28 CDK98736.1 - 2.3e-16 60.1 0.0 2.6e-16 59.9 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain EF-hand_5 PF13202.6 CDK98736.1 - 0.0038 16.6 1.7 0.0072 15.8 1.7 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CDK98736.1 - 0.047 13.6 0.5 0.13 12.3 0.3 1.8 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 CDK98736.1 - 0.095 12.3 0.8 0.17 11.5 0.8 1.4 1 0 0 1 1 1 0 EF hand HTH_10 PF04967.12 CDK98736.1 - 0.18 11.7 0.2 0.48 10.3 0.0 1.7 2 0 0 2 2 2 0 HTH DNA binding domain AAA_33 PF13671.6 CDK98737.1 - 9.8e-22 77.7 0.0 2.1e-21 76.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain APH PF01636.23 CDK98737.1 - 3.2e-07 30.5 4.1 3.2e-07 30.5 4.1 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Zeta_toxin PF06414.12 CDK98737.1 - 4.8e-07 29.2 0.0 8.1e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.6 CDK98737.1 - 0.00069 20.2 0.0 0.0017 18.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 CDK98737.1 - 0.027 14.3 0.0 0.074 12.9 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.6 CDK98737.1 - 0.082 13.3 0.3 0.2 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Usp PF00582.26 CDK98738.1 - 2e-19 70.5 14.5 3.8e-09 37.2 0.1 3.8 3 1 0 3 3 3 3 Universal stress protein family DotD PF16816.5 CDK98738.1 - 0.012 15.6 0.0 0.11 12.5 0.0 2.3 2 0 0 2 2 2 0 DotD protein Phosphonate-bd PF12974.7 CDK98739.1 - 7.6e-51 173.0 0.0 1.1e-50 172.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein HATPase_c PF02518.26 CDK98739.1 - 1.2e-22 80.5 0.0 2.3e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98739.1 - 2.1e-14 53.3 0.2 7.9e-14 51.4 0.2 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 CDK98739.1 - 9.9e-11 41.8 0.0 2.6e-10 40.5 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDK98739.1 - 1e-09 38.6 0.6 4.4e-09 36.6 0.1 2.3 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 CDK98739.1 - 5.5e-08 32.8 0.0 1.9e-07 31.1 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDK98739.1 - 4.8e-07 29.6 0.3 3.8e-06 26.8 0.0 2.7 3 0 0 3 3 3 1 PAS domain NMT1 PF09084.11 CDK98739.1 - 0.00094 19.2 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 NMT1/THI5 like SBP_bac_3 PF00497.20 CDK98739.1 - 0.0017 17.8 0.0 0.028 13.9 0.0 2.2 1 1 1 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 HATPase_c_5 PF14501.6 CDK98739.1 - 0.027 14.4 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 GHKL domain FliJ PF02050.16 CDK98739.1 - 0.17 12.1 2.9 2.4 8.4 1.4 2.6 2 0 0 2 2 2 0 Flagellar FliJ protein Nitro_FeMo-Co PF02579.17 CDK98740.1 - 1.9e-13 50.6 0.0 2.1e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Dinitrogenase iron-molybdenum cofactor ABC_tran PF00005.27 CDK98741.1 - 5.3e-28 98.2 0.0 8.9e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter TOBE PF03459.17 CDK98741.1 - 4e-14 52.6 0.9 1.6e-12 47.6 0.2 3.2 3 1 0 3 3 3 1 TOBE domain AAA_21 PF13304.6 CDK98741.1 - 9.1e-06 25.7 1.1 0.084 12.7 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK98741.1 - 0.0002 20.9 0.1 0.18 11.2 0.1 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDK98741.1 - 0.0031 17.8 0.2 0.0086 16.3 0.1 1.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDK98741.1 - 0.0034 17.8 0.1 0.0077 16.6 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CDK98741.1 - 0.004 17.7 0.1 0.0062 17.1 0.1 1.1 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDK98741.1 - 0.0044 16.9 0.0 0.0066 16.4 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CDK98741.1 - 0.008 15.9 0.1 0.018 14.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain TOBE_2 PF08402.10 CDK98741.1 - 0.02 15.0 0.0 0.97 9.6 0.0 2.6 1 1 1 2 2 2 0 TOBE domain AAA PF00004.29 CDK98741.1 - 0.048 14.1 0.0 0.38 11.2 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CDK98741.1 - 0.061 13.0 0.2 0.12 12.1 0.2 1.4 1 0 0 1 1 1 0 AAA domain BPD_transp_1 PF00528.22 CDK98742.1 - 8.5e-23 81.0 10.7 9.9e-23 80.8 10.7 1.1 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component YjgF_endoribonc PF14588.6 CDK98743.1 - 3.1e-42 144.2 0.1 3.3e-42 144.1 0.1 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.21 CDK98743.1 - 5.7e-22 78.0 0.0 8e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP EamA PF00892.20 CDK98744.1 - 5.2e-33 114.1 39.1 6.8e-21 74.9 14.2 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 CDK98744.1 - 0.00022 20.7 6.2 0.0011 18.4 3.2 3.0 1 1 0 2 2 2 1 Triose-phosphate Transporter family DUF2339 PF10101.9 CDK98744.1 - 3.6 6.0 47.7 4.9 5.6 47.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) LysR_substrate PF03466.20 CDK98745.1 - 1e-22 80.6 7.7 1.5e-22 80.0 7.7 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDK98745.1 - 7.3e-22 77.1 1.9 7.6e-22 77.0 0.3 1.9 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family GGDEF PF00990.21 CDK98746.1 - 5.6e-38 130.2 0.0 8.1e-38 129.7 0.0 1.2 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GGDEF_2 PF17853.1 CDK98746.1 - 0.0097 16.2 0.1 0.019 15.2 0.1 1.6 1 0 0 1 1 1 1 GGDEF-like domain GCH_III PF05165.12 CDK98746.1 - 0.071 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase III DUF4141 PF13605.6 CDK98746.1 - 0.12 11.7 1.4 0.26 10.6 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4141) AMP-binding_C_2 PF14535.6 CDK98747.1 - 2.7e-26 91.7 0.0 6.2e-26 90.5 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 CDK98747.1 - 2.5e-15 56.0 0.9 9.2e-15 54.1 0.9 1.7 1 1 0 1 1 1 1 AMP-binding enzyme COQ9 PF08511.11 CDK98748.1 - 6.4e-30 102.7 3.4 1e-29 102.1 3.4 1.3 1 0 0 1 1 1 1 COQ9 TetR_C_23 PF17931.1 CDK98748.1 - 0.055 13.6 0.7 0.083 13.0 0.7 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Ribosomal_S21 PF01165.20 CDK98750.1 - 4.6e-20 71.1 10.0 4.6e-20 71.1 10.0 1.7 1 1 1 2 2 2 1 Ribosomal protein S21 RF-1 PF00472.20 CDK98750.1 - 1 9.3 7.1 1.3 9.0 7.1 1.1 1 0 0 1 1 1 0 RF-1 domain DUF4337 PF14235.6 CDK98750.1 - 1.6 8.8 3.6 1.9 8.6 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) MCPsignal PF00015.21 CDK98751.1 - 1.1e-14 54.6 1.5 1.7e-14 54.0 1.0 1.5 1 1 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CDK98751.1 - 5.9e-11 42.6 0.0 1e-10 41.8 0.0 1.4 1 0 0 1 1 1 1 Cache domain PNTB PF02233.16 CDK98752.1 - 1.5e-192 640.6 24.6 1.7e-192 640.5 24.6 1.0 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit TPP_enzyme_M PF00205.22 CDK98752.1 - 0.029 14.1 0.1 0.11 12.2 0.1 2.0 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain PNTB_4TM PF12769.7 CDK98753.1 - 8.2e-37 125.5 8.6 8.2e-37 125.5 8.6 1.5 2 0 0 2 2 2 1 4TM region of pyridine nucleotide transhydrogenase, mitoch DUF3392 PF11872.8 CDK98753.1 - 0.0041 17.4 3.4 0.0041 17.4 3.4 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3392) AlaDh_PNT_C PF01262.21 CDK98754.1 - 1.2e-70 237.1 2.0 1.2e-70 237.1 2.0 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CDK98754.1 - 2.9e-45 153.9 2.3 5.8e-45 152.9 2.3 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain 2-Hacid_dh_C PF02826.19 CDK98754.1 - 2.8e-05 23.5 0.6 0.16 11.3 0.1 3.6 2 1 1 4 4 4 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 CDK98754.1 - 0.00077 18.8 0.2 0.0013 18.1 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CDK98754.1 - 0.14 12.2 1.5 0.57 10.3 0.0 2.6 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase DUF4956 PF16316.5 CDK98755.1 - 0.12 12.0 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4956) CHASE2 PF05226.11 CDK98756.1 - 6.9e-51 173.4 3.5 6.9e-51 173.4 3.5 1.5 2 0 0 2 2 2 1 CHASE2 domain Guanylate_cyc PF00211.20 CDK98756.1 - 6.6e-24 84.5 0.0 1.1e-23 83.9 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain OmpA PF00691.20 CDK98757.1 - 4.3e-17 62.3 0.0 6.4e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 OmpA family FecR PF04773.13 CDK98758.1 - 3.9e-09 37.0 1.0 4.7e-09 36.7 0.3 1.5 2 0 0 2 2 2 1 FecR protein cNMP_binding PF00027.29 CDK98759.1 - 3.2e-21 75.2 0.0 1.1e-20 73.5 0.0 2.0 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Peptidase_M3 PF01432.20 CDK98760.1 - 8.6e-32 111.0 0.0 7.8e-31 107.8 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M3 Peptidase_M3_N PF08439.10 CDK98760.1 - 2.8e-20 72.4 0.0 7.4e-20 71.0 0.0 1.8 1 0 0 1 1 1 1 Oligopeptidase F HEAT PF02985.22 CDK98760.1 - 0.012 15.8 0.0 0.11 12.9 0.0 2.6 2 0 0 2 2 2 0 HEAT repeat Peptidase_M78 PF06114.13 CDK98760.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 IrrE N-terminal-like domain AMP-binding PF00501.28 CDK98761.1 - 2.9e-94 316.1 0.0 4.2e-94 315.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDK98761.1 - 0.038 15.0 0.6 0.12 13.3 0.6 2.0 1 1 0 1 1 1 0 AMP-binding enzyme C-terminal domain SBP_bac_3 PF00497.20 CDK98762.1 - 1e-13 51.3 0.0 1.3e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 HATPase_c PF02518.26 CDK98763.1 - 3.2e-23 82.4 0.0 6.9e-23 81.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CHASE5 PF17149.4 CDK98763.1 - 3.8e-21 75.0 0.0 7.8e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 Periplasmic sensor domain found in signal transduction proteins HisKA PF00512.25 CDK98763.1 - 1.9e-12 47.1 0.7 8.6e-12 44.9 0.0 2.5 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CDK98763.1 - 0.00066 19.5 0.0 0.0018 18.1 0.0 1.7 1 0 0 1 1 1 1 GHKL domain HAMP PF00672.25 CDK98763.1 - 0.0082 16.5 0.0 0.035 14.5 0.0 2.2 2 0 0 2 2 2 1 HAMP domain KfrA_N PF11740.8 CDK98763.1 - 0.029 15.1 0.9 0.029 15.1 0.9 1.9 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Rab5-bind PF09311.11 CDK98763.1 - 0.034 13.5 0.7 0.065 12.6 0.4 1.5 1 1 0 1 1 1 0 Rabaptin-like protein KxDL PF10241.9 CDK98763.1 - 0.13 12.6 0.4 6.5 7.1 0.6 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein GDP_Man_Dehyd PF16363.5 CDK98764.1 - 2.5e-53 181.6 0.0 2.9e-53 181.4 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDK98764.1 - 5e-52 176.8 0.0 5.8e-52 176.5 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDK98764.1 - 1.2e-12 47.6 0.0 1.4e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CDK98764.1 - 5.4e-11 42.0 0.0 7.3e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CDK98764.1 - 9.1e-07 28.3 0.0 7.7e-06 25.2 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CDK98764.1 - 2.4e-06 27.2 0.0 2.1e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_4 PF07993.12 CDK98764.1 - 2.8e-05 23.4 0.4 0.00027 20.2 0.4 2.2 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 CDK98764.1 - 8.2e-05 22.6 0.1 0.00016 21.7 0.1 1.4 1 1 0 1 1 1 1 KR domain POR PF01558.18 CDK98765.1 - 1.3e-25 90.5 0.1 2.2e-25 89.7 0.1 1.3 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase TPP_enzyme_C PF02775.21 CDK98765.1 - 5.5e-06 26.2 0.4 1.5e-05 24.8 0.4 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF768 PF05589.11 CDK98765.1 - 0.17 11.9 0.3 0.54 10.3 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF768) TPR_19 PF14559.6 CDK98766.1 - 8.4e-22 77.5 39.2 4e-07 30.5 2.0 7.5 2 2 5 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 CDK98766.1 - 1.6e-18 65.2 32.3 0.0077 16.3 0.0 10.3 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_1 PF00515.28 CDK98766.1 - 2.2e-18 65.2 12.5 0.091 12.6 0.0 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDK98766.1 - 5.8e-18 65.3 71.5 8.2e-05 23.2 2.6 7.8 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 CDK98766.1 - 8.1e-17 60.0 5.0 0.09 13.0 0.1 9.2 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDK98766.1 - 2.6e-14 52.5 17.6 0.13 12.7 0.1 9.9 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDK98766.1 - 7.7e-14 51.1 17.6 0.0012 18.5 0.2 7.9 4 3 4 8 8 8 5 TPR repeat TPR_14 PF13428.6 CDK98766.1 - 5.3e-13 48.6 60.9 0.015 16.1 5.9 11.2 2 2 8 10 10 10 7 Tetratricopeptide repeat TPR_12 PF13424.6 CDK98766.1 - 5.5e-13 49.0 44.1 6.5e-05 23.2 3.3 7.7 3 3 3 6 6 6 5 Tetratricopeptide repeat Glyco_transf_9 PF01075.17 CDK98766.1 - 8.2e-08 31.8 5.4 0.00072 18.9 0.3 2.4 2 0 0 2 2 2 2 Glycosyltransferase family 9 (heptosyltransferase) TPR_9 PF13371.6 CDK98766.1 - 0.00057 20.0 48.7 0.0026 17.9 3.8 7.5 2 2 6 8 8 8 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CDK98766.1 - 0.0012 19.0 4.8 0.49 10.6 0.2 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 CDK98766.1 - 0.0035 17.6 19.0 0.31 11.4 6.6 5.6 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_5 PF12688.7 CDK98766.1 - 0.0089 16.3 16.0 0.057 13.7 0.8 4.1 3 1 0 3 3 3 2 Tetratrico peptide repeat TPR_7 PF13176.6 CDK98766.1 - 0.014 15.3 21.4 1.2 9.4 0.0 8.5 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDK98766.1 - 0.086 13.5 0.3 0.086 13.5 0.3 11.0 11 0 0 11 11 9 0 Tetratricopeptide repeat TPR_15 PF13429.6 CDK98766.1 - 0.17 11.1 21.4 2 7.5 1.2 4.1 2 2 3 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDK98766.1 - 0.64 10.8 28.9 2.1 9.2 0.0 8.1 9 0 0 9 9 7 0 Tetratricopeptide repeat ETF_QO PF05187.13 CDK98767.1 - 4.5e-48 161.7 0.1 7e-48 161.1 0.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 CDK98767.1 - 1.9e-09 37.6 0.6 0.0006 19.5 0.2 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDK98767.1 - 6.1e-09 35.4 0.1 2.9e-05 23.4 0.2 2.1 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 CDK98767.1 - 1e-07 31.5 0.0 3.1e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CDK98767.1 - 7.2e-07 29.4 0.0 4.7e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CDK98767.1 - 4.2e-05 22.4 0.1 6.2e-05 21.9 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 CDK98767.1 - 0.00036 19.9 0.1 0.00054 19.3 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDK98767.1 - 0.00042 20.8 0.0 0.93 10.1 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDK98767.1 - 0.00047 19.5 0.0 0.00067 19.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDK98767.1 - 0.00077 18.6 1.2 0.00099 18.3 0.1 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 CDK98767.1 - 0.0011 18.3 1.0 0.0065 15.8 0.1 2.3 2 1 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 CDK98767.1 - 0.017 14.0 0.1 0.75 8.6 0.1 2.3 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_9 PF13454.6 CDK98767.1 - 0.018 15.0 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 CDK98767.1 - 0.023 13.9 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 CDK98767.1 - 0.027 13.8 0.1 0.042 13.2 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Mqo PF06039.15 CDK98767.1 - 0.12 11.0 0.0 0.16 10.5 0.0 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Acyl-CoA_dh_1 PF00441.24 CDK98768.1 - 3.1e-26 92.4 4.4 3.1e-26 92.4 4.4 2.2 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_C PF12806.7 CDK98768.1 - 1.3e-25 90.0 7.8 3.5e-25 88.5 7.8 1.8 1 0 0 1 1 1 1 Acetyl-CoA dehydrogenase C-terminal like Acyl-CoA_dh_M PF02770.19 CDK98768.1 - 5.2e-15 55.4 0.0 2.5e-14 53.3 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CDK98768.1 - 2.3e-13 50.8 0.6 5.2e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain AcylCoA_DH_N PF12418.8 CDK98768.1 - 6.7e-08 32.4 0.0 1.3e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase N terminal Acyl-CoA_dh_2 PF08028.11 CDK98768.1 - 4.3e-06 27.0 1.6 4.3e-06 27.0 1.6 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain 3HCDH_N PF02737.18 CDK98769.1 - 2.4e-63 213.3 0.1 2.9e-63 213.0 0.1 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CDK98769.1 - 1.5e-34 118.5 0.0 4.3e-34 117.0 0.0 1.8 2 0 0 2 2 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CDK98769.1 - 8.3e-07 29.3 0.7 2e-06 28.1 0.7 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CDK98769.1 - 0.00051 20.6 0.3 0.00094 19.7 0.3 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent adh_short_C2 PF13561.6 CDK98769.1 - 0.00079 19.0 0.2 0.0011 18.6 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase UDPG_MGDP_dh_N PF03721.14 CDK98769.1 - 0.0023 17.6 0.1 0.0034 17.0 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CDK98769.1 - 0.0036 17.3 0.5 0.0097 15.9 0.2 2.0 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 CDK98769.1 - 0.0068 15.8 0.5 0.012 15.0 0.2 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CDK98769.1 - 0.0085 16.3 0.5 0.016 15.4 0.5 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CDK98769.1 - 0.024 14.7 0.6 0.059 13.4 0.4 1.9 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 CDK98769.1 - 0.03 13.6 0.0 0.042 13.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DFP PF04127.15 CDK98769.1 - 0.031 14.1 0.1 0.048 13.5 0.1 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein adh_short PF00106.25 CDK98769.1 - 0.048 13.1 0.3 0.068 12.6 0.3 1.3 1 0 0 1 1 1 0 short chain dehydrogenase TrkA_N PF02254.18 CDK98769.1 - 0.051 13.8 0.3 0.13 12.6 0.2 1.9 1 1 0 1 1 1 0 TrkA-N domain ApbA PF02558.16 CDK98769.1 - 0.052 13.2 0.6 0.15 11.7 0.3 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 CDK98769.1 - 0.11 13.0 0.2 0.2 12.2 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ETF PF01012.21 CDK98770.1 - 7.5e-37 127.0 14.6 1.1e-36 126.4 14.6 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 CDK98770.1 - 1.4e-36 124.4 0.4 1.4e-36 124.4 0.4 3.0 2 1 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.21 CDK98771.1 - 4.4e-49 166.8 2.4 5.9e-49 166.4 2.4 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain AMP-binding PF00501.28 CDK98772.1 - 1.5e-90 303.8 0.0 1.8e-90 303.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDK98772.1 - 4.5e-20 72.4 0.2 1.1e-19 71.2 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Response_reg PF00072.24 CDK98773.1 - 6.1e-24 84.3 0.0 9.5e-24 83.7 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK98773.1 - 6.3e-19 67.8 0.0 1.9e-18 66.3 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal FleQ PF06490.11 CDK98773.1 - 0.12 12.8 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ dCache_2 PF08269.11 CDK98774.1 - 1.3e-56 192.0 0.1 2.1e-56 191.3 0.1 1.3 1 0 0 1 1 1 1 Cache domain sCache_2 PF17200.4 CDK98774.1 - 3.5e-54 182.8 0.3 2.5e-31 108.6 0.0 2.5 2 1 1 3 3 2 2 Single Cache domain 2 Cache_3-Cache_2 PF17201.4 CDK98774.1 - 8.5e-23 81.0 0.0 6.8e-13 48.5 0.0 2.4 1 1 1 2 2 2 2 Cache 3/Cache 2 fusion domain PAS_4 PF08448.10 CDK98774.1 - 6.8e-17 61.7 0.6 2.6e-16 59.8 0.1 2.3 2 0 0 2 2 2 1 PAS fold HATPase_c PF02518.26 CDK98774.1 - 9.2e-16 58.4 0.0 2.2e-15 57.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK98774.1 - 1.5e-15 57.3 0.1 4.6e-15 55.8 0.1 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HAMP PF00672.25 CDK98774.1 - 7.9e-14 51.8 2.3 7.9e-14 51.8 2.3 2.7 2 0 0 2 2 2 1 HAMP domain dCache_1 PF02743.18 CDK98774.1 - 1.6e-09 37.9 1.3 2.6e-07 30.7 0.9 3.5 2 1 0 2 2 2 1 Cache domain HisKA PF00512.25 CDK98774.1 - 2.1e-09 37.3 1.1 1.2e-07 31.7 0.0 3.3 3 0 0 3 3 2 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CDK98774.1 - 6.6e-06 26.1 0.0 2.1e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDK98774.1 - 1.2e-05 25.1 0.1 3.8e-05 23.6 0.1 1.9 1 0 0 1 1 1 1 PAS domain HATPase_c_2 PF13581.6 CDK98774.1 - 0.00011 22.1 0.0 0.00028 20.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain sCache_3_2 PF17203.4 CDK98774.1 - 0.00036 20.7 1.0 0.28 11.3 0.0 3.1 3 0 0 3 3 3 2 Single cache domain 3 HPTransfase PF10090.9 CDK98774.1 - 0.024 14.4 0.1 0.16 11.8 0.0 2.3 2 0 0 2 2 2 0 Histidine phosphotransferase C-terminal domain PAS_9 PF13426.7 CDK98774.1 - 0.025 14.8 0.0 0.079 13.2 0.0 1.9 1 0 0 1 1 1 0 PAS domain PAS_10 PF13596.6 CDK98774.1 - 0.029 15.0 0.0 0.093 13.3 0.0 1.9 2 0 0 2 2 2 0 PAS domain PAS_7 PF12860.7 CDK98774.1 - 0.029 14.5 0.0 0.2 11.8 0.0 2.6 3 0 0 3 3 3 0 PAS fold RHH_4 PF13467.6 CDK98775.1 - 7.6e-24 83.4 0.0 8.5e-24 83.2 0.0 1.0 1 0 0 1 1 1 1 Ribbon-helix-helix domain EF-hand_5 PF13202.6 CDK98775.1 - 0.13 11.8 0.2 0.34 10.5 0.1 1.9 2 0 0 2 2 2 0 EF hand FlaF PF07309.11 CDK98776.1 - 6.3e-05 23.0 0.3 0.00023 21.1 0.3 1.8 1 1 0 1 1 1 1 Flagellar protein FlaF DUF2934 PF11154.8 CDK98776.1 - 0.0002 20.9 2.1 0.00046 19.8 2.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2934) DUF983 PF06170.12 CDK98777.1 - 5.1e-26 90.9 6.3 5.1e-26 90.9 6.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF983) DUF4044 PF13253.6 CDK98777.1 - 0.29 10.7 6.2 0.51 9.9 6.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) zf-dskA_traR PF01258.17 CDK98777.1 - 0.62 10.1 8.3 8.3 6.4 0.2 2.3 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger Glutaredoxin PF00462.24 CDK98778.1 - 9e-20 70.7 0.1 1.6e-19 69.9 0.0 1.4 2 0 0 2 2 2 1 Glutaredoxin BolA PF01722.18 CDK98779.1 - 6.2e-17 61.6 0.0 6.8e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein SnoaL PF07366.12 CDK98779.1 - 0.042 13.6 0.2 0.33 10.7 0.0 1.9 1 1 1 2 2 2 0 SnoaL-like polyketide cyclase EamA PF00892.20 CDK98780.1 - 1.7e-15 57.4 39.1 9.8e-12 45.2 13.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family zf_PR_Knuckle PF18445.1 CDK98780.1 - 0.037 13.8 0.8 0.094 12.5 0.3 1.9 2 0 0 2 2 2 0 PR zinc knuckle motif GGDEF PF00990.21 CDK98781.1 - 1.9e-45 154.5 0.8 2.7e-45 154.0 0.8 1.2 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GAF_2 PF13185.6 CDK98781.1 - 4.5e-16 59.4 0.2 1.1e-15 58.1 0.2 1.7 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 CDK98781.1 - 8.8e-10 39.3 0.1 1.8e-09 38.3 0.1 1.6 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 CDK98781.1 - 1.7e-09 38.1 0.2 8.9e-09 35.8 0.1 2.0 2 0 0 2 2 2 1 GAF domain AIRS_C PF02769.22 CDK98782.1 - 2.5e-58 196.7 6.4 1.2e-34 119.7 0.4 2.6 2 1 1 3 3 3 2 AIR synthase related protein, C-terminal domain AIRS PF00586.24 CDK98782.1 - 4e-50 168.4 4.4 3.7e-24 85.2 0.3 2.5 2 0 0 2 2 2 2 AIR synthase related protein, N-terminal domain FGAR-AT_linker PF18072.1 CDK98782.1 - 2e-13 50.6 0.0 4.1e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain GATase_5 PF13507.6 CDK98783.1 - 2.7e-42 144.7 0.0 3.3e-42 144.4 0.0 1.0 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase_3 PF07685.14 CDK98783.1 - 1.6e-07 31.1 0.0 2.9e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 CDK98783.1 - 4.9e-06 26.4 0.0 7.5e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 CDK98783.1 - 9.9e-05 22.2 0.0 0.00013 21.8 0.0 1.3 1 1 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 CDK98783.1 - 0.12 12.2 0.0 0.33 10.8 0.0 1.7 2 0 0 2 2 2 0 SNO glutamine amidotransferase family BPD_transp_1 PF00528.22 CDK98784.1 - 1e-13 51.4 33.9 1.6e-09 37.8 12.9 4.0 2 2 2 4 4 4 2 Binding-protein-dependent transport system inner membrane component DUF1422 PF07226.11 CDK98784.1 - 0.11 12.5 6.3 2.9 7.9 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1422) ABC_tran PF00005.27 CDK98785.1 - 4.6e-32 111.4 0.0 6.9e-32 110.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98785.1 - 1.3e-07 31.8 0.1 0.00031 20.6 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system TOBE_2 PF08402.10 CDK98785.1 - 4.9e-06 26.6 1.8 8.4e-06 25.9 0.5 2.1 2 0 0 2 2 2 1 TOBE domain Rad17 PF03215.15 CDK98785.1 - 0.00097 19.1 0.1 0.0015 18.5 0.1 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain SbcCD_C PF13558.6 CDK98785.1 - 0.0034 17.6 0.1 0.032 14.5 0.1 2.2 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 CDK98785.1 - 0.0093 16.1 0.0 0.033 14.4 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 CDK98785.1 - 0.015 15.8 0.1 0.04 14.4 0.1 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDK98785.1 - 0.038 14.4 0.2 0.069 13.5 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 CDK98785.1 - 0.076 13.0 0.1 0.17 11.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDK98785.1 - 0.14 12.5 0.2 0.32 11.3 0.2 1.5 1 0 0 1 1 1 0 AAA domain SBP_bac_6 PF13343.6 CDK98786.1 - 3.4e-22 79.1 0.3 5e-22 78.5 0.3 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 CDK98786.1 - 5.3e-21 75.7 2.0 7.4e-21 75.2 2.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CDK98786.1 - 2.7e-17 63.7 0.8 4.2e-17 63.1 0.8 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CDK98786.1 - 1.2e-15 57.9 4.2 2.3e-15 57.0 4.2 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein EAL PF00563.20 CDK98787.1 - 4.1e-70 236.0 0.0 7e-70 235.2 0.0 1.4 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK98787.1 - 1.9e-47 161.0 0.0 3.5e-47 160.1 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDK98787.1 - 8.6e-27 93.4 0.0 4.2e-12 46.2 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 CDK98787.1 - 1.4e-15 57.3 0.0 1.8e-06 27.9 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 CDK98787.1 - 5e-15 55.7 0.5 3.6e-06 27.2 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.12 CDK98787.1 - 1.9e-14 53.7 0.1 5.6e-10 39.4 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 CDK98787.1 - 3.8e-14 52.3 0.2 3.2e-05 23.8 0.0 3.6 3 0 0 3 3 3 2 PAS domain PAS_7 PF12860.7 CDK98787.1 - 0.0038 17.4 0.4 0.48 10.6 0.1 3.5 2 2 0 2 2 2 1 PAS fold AMP-binding PF00501.28 CDK98788.1 - 6.8e-93 311.6 0.0 1.2e-92 310.8 0.0 1.3 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDK98788.1 - 2.7e-17 63.5 0.1 1.4e-16 61.2 0.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain EamA PF00892.20 CDK98789.1 - 4.4e-39 133.8 42.2 5.9e-23 81.6 13.6 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 CDK98789.1 - 3.1e-05 23.5 8.0 0.044 13.1 3.4 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family SLC35F PF06027.12 CDK98789.1 - 0.013 15.0 7.8 0.017 14.7 7.8 1.1 1 0 0 1 1 1 0 Solute carrier family 35 Lipase_GDSL_2 PF13472.6 CDK98790.1 - 2.6e-08 34.5 0.2 9.1e-08 32.7 0.1 1.9 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family HIT PF01230.23 CDK98791.1 - 3.1e-15 56.7 0.0 3.8e-15 56.4 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CDK98791.1 - 0.061 13.8 0.0 0.099 13.1 0.0 1.3 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding FAD_binding_7 PF03441.14 CDK98793.1 - 7e-82 273.8 0.7 9.7e-82 273.3 0.7 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CDK98793.1 - 6.4e-35 120.6 0.0 1.1e-34 119.8 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase DUF454 PF04304.13 CDK98794.1 - 1.5e-39 134.6 9.9 1.7e-39 134.4 9.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF454) MFS_1 PF07690.16 CDK98795.1 - 2.1e-20 73.0 55.2 4.2e-18 65.4 33.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PadR PF03551.14 CDK98796.1 - 5.7e-20 71.1 0.0 7.8e-20 70.6 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.6 CDK98796.1 - 2.3e-07 30.9 0.0 3.9e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain Replic_Relax PF13814.6 CDK98796.1 - 0.0084 16.2 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Replication-relaxation RTP PF02334.16 CDK98796.1 - 0.029 15.0 0.0 0.04 14.5 0.0 1.1 1 0 0 1 1 1 0 Replication terminator protein AphA_like PF14557.6 CDK98796.1 - 0.064 13.0 0.0 0.092 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator TetR_N PF00440.23 CDK98797.1 - 8e-17 60.8 0.2 1.4e-16 60.0 0.2 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_24 PF17932.1 CDK98797.1 - 0.00015 22.0 0.0 0.0006 20.1 0.0 2.0 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_C_27 PF17935.1 CDK98797.1 - 0.002 18.1 0.0 0.008 16.2 0.0 1.9 1 1 1 2 2 2 1 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 CDK98797.1 - 0.029 14.5 0.0 0.045 13.9 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase AMP-binding PF00501.28 CDK98798.1 - 1e-63 215.4 0.0 1.6e-63 214.8 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Acyltransferase PF01553.21 CDK98798.1 - 2.5e-17 62.8 0.0 7.2e-17 61.3 0.0 1.8 2 0 0 2 2 2 1 Acyltransferase MFS_1 PF07690.16 CDK98798.1 - 3.3e-11 42.7 51.1 4.9e-09 35.6 32.7 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily AMP-binding_C PF13193.6 CDK98798.1 - 0.0027 18.6 0.1 0.0084 17.1 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain AAT PF03417.16 CDK98799.1 - 0.0002 21.1 0.0 0.00027 20.7 0.0 1.2 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase DUF2339 PF10101.9 CDK98800.1 - 2.5e-145 485.7 139.0 6.4e-144 481.1 139.0 2.1 1 1 0 1 1 1 1 Predicted membrane protein (DUF2339) LapA_dom PF06305.11 CDK98800.1 - 0.027 14.3 0.3 0.027 14.3 0.3 6.1 6 0 0 6 6 6 0 Lipopolysaccharide assembly protein A domain Mito_fiss_reg PF05308.11 CDK98800.1 - 3.9 7.5 7.0 5.9 6.9 7.0 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Response_reg PF00072.24 CDK98801.1 - 1.7e-23 82.9 0.0 2.7e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK98801.1 - 5.2e-18 64.9 0.0 4.3e-17 62.0 0.0 2.3 3 0 0 3 3 3 1 Transcriptional regulatory protein, C terminal EccE PF11203.8 CDK98801.1 - 0.1 12.9 0.1 0.34 11.2 0.1 1.8 1 0 0 1 1 1 0 Putative type VII ESX secretion system translocon, EccE SPAR_C PF11881.8 CDK98801.1 - 0.14 12.1 0.1 0.27 11.1 0.0 1.5 2 0 0 2 2 2 0 C-terminal domain of SPAR protein Reg_prop PF07494.11 CDK98802.1 - 3.9e-31 103.1 17.7 0.0067 16.5 0.0 12.6 13 0 0 13 13 13 8 Two component regulator propeller Response_reg PF00072.24 CDK98802.1 - 5.4e-24 84.5 0.8 5.5e-23 81.3 1.7 2.3 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 CDK98802.1 - 2e-21 76.6 0.2 1e-20 74.3 0.2 2.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98802.1 - 1.9e-14 53.4 0.3 5e-14 52.1 0.3 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Y_Y_Y PF07495.13 CDK98802.1 - 1.1e-10 41.3 0.0 2.2e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Y_Y_Y domain Hpt PF01627.23 CDK98802.1 - 8.5e-08 32.4 2.8 3.1e-07 30.5 2.8 2.0 1 0 0 1 1 1 1 Hpt domain SGL PF08450.12 CDK98802.1 - 9.6e-07 28.6 2.6 0.66 9.5 0.0 6.0 3 2 2 6 6 6 2 SMP-30/Gluconolactonase/LRE-like region Ion_trans PF00520.31 CDK98803.1 - 8.4e-43 146.4 11.6 9.8e-43 146.1 11.6 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 CDK98803.1 - 1.2e-06 27.5 9.2 1.3e-06 27.4 2.3 2.0 1 1 1 2 2 2 2 Polycystin cation channel DUF962 PF06127.11 CDK98803.1 - 0.00066 19.7 0.1 0.0033 17.5 0.0 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF962) YfdX PF10938.8 CDK98803.1 - 0.014 15.4 0.2 0.022 14.7 0.2 1.3 1 0 0 1 1 1 0 YfdX protein Beta-lactamase PF00144.24 CDK98804.1 - 3.4e-55 187.6 2.0 4.3e-55 187.2 2.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 CDK98804.1 - 5.5e-06 26.1 0.0 0.023 14.3 0.0 2.4 2 0 0 2 2 2 2 Beta-lactamase enzyme family TMEM43 PF07787.12 CDK98805.1 - 9.4e-81 270.9 0.1 2.9e-80 269.3 0.0 1.7 2 0 0 2 2 2 1 Transmembrane protein 43 DUF805 PF05656.14 CDK98806.1 - 4.6e-26 91.3 0.5 5e-26 91.1 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF805) 7TMR-DISM_7TM PF07695.11 CDK98806.1 - 0.011 15.7 1.7 0.013 15.4 1.7 1.1 1 0 0 1 1 1 0 7TM diverse intracellular signalling UPF0014 PF03649.13 CDK98806.1 - 0.04 13.3 0.2 0.044 13.1 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0014) DUF4231 PF14015.6 CDK98806.1 - 0.057 13.9 1.5 0.12 12.9 1.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4231) Neur_chan_LBD PF02931.23 CDK98808.1 - 2.9e-06 26.9 0.0 0.0013 18.2 0.0 2.1 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Ribosomal_60s PF00428.19 CDK98808.1 - 0.025 15.2 1.2 0.025 15.2 1.2 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein HSP70 PF00012.20 CDK98809.1 - 2.7e-20 72.1 0.0 2.7e-09 35.8 0.0 3.0 3 0 0 3 3 3 3 Hsp70 protein MreB_Mbl PF06723.13 CDK98809.1 - 5.2e-06 25.5 0.1 0.0034 16.3 0.0 2.6 3 0 0 3 3 3 2 MreB/Mbl protein PBP_like_2 PF12849.7 CDK98810.1 - 1.6e-08 34.5 0.0 2.8e-08 33.8 0.0 1.4 1 1 0 1 1 1 1 PBP superfamily domain SBP_bac_11 PF13531.6 CDK98810.1 - 1.4e-05 25.0 1.6 2.5e-05 24.1 1.6 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein LysR_substrate PF03466.20 CDK98810.1 - 0.00093 18.6 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 LysR substrate binding domain HATPase_c PF02518.26 CDK98811.1 - 0.00013 22.4 0.0 0.00024 21.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98811.1 - 0.00024 21.1 1.0 0.00039 20.4 0.0 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain SlyX PF04102.12 CDK98812.1 - 5.6e-21 74.9 2.2 6.2e-21 74.8 2.2 1.0 1 0 0 1 1 1 1 SlyX ATG16 PF08614.11 CDK98812.1 - 0.013 15.8 2.6 0.015 15.5 2.6 1.0 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF16 PF01519.16 CDK98812.1 - 0.014 15.9 0.2 0.016 15.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 TolA_bind_tri PF16331.5 CDK98812.1 - 0.064 13.3 4.5 0.079 13.0 4.5 1.2 1 0 0 1 1 1 0 TolA binding protein trimerisation Spc42p PF11544.8 CDK98812.1 - 0.11 12.5 0.1 0.18 11.8 0.1 1.4 1 1 0 1 1 1 0 Spindle pole body component Spc42p PBP_like_2 PF12849.7 CDK98813.1 - 1.1e-22 81.0 1.0 2.1e-22 80.1 1.0 1.4 1 1 0 1 1 1 1 PBP superfamily domain SBP_bac_11 PF13531.6 CDK98813.1 - 2.3e-05 24.2 7.1 0.00022 21.1 7.1 2.0 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein PBP_like PF12727.7 CDK98813.1 - 0.00017 20.8 0.2 0.00026 20.2 0.2 1.3 1 0 0 1 1 1 1 PBP superfamily domain LysR_substrate PF03466.20 CDK98813.1 - 0.019 14.4 0.1 0.23 10.8 0.0 2.2 2 0 0 2 2 2 0 LysR substrate binding domain PBP_like_2 PF12849.7 CDK98814.1 - 2e-28 99.8 0.0 1e-27 97.6 0.0 1.8 1 1 0 1 1 1 1 PBP superfamily domain PBP_like PF12727.7 CDK98814.1 - 8e-14 51.2 0.1 1.2e-13 50.7 0.1 1.3 1 0 0 1 1 1 1 PBP superfamily domain SBP_bac_11 PF13531.6 CDK98814.1 - 3.7e-07 30.1 0.4 7.7e-07 29.1 0.4 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein LysR_substrate PF03466.20 CDK98814.1 - 1.2e-05 24.8 0.2 2e-05 24.0 0.2 1.6 1 1 0 1 1 1 1 LysR substrate binding domain DUF1515 PF07439.11 CDK98814.1 - 0.09 12.8 0.3 0.25 11.4 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) NMT1_3 PF16868.5 CDK98815.1 - 6.9e-15 55.2 0.0 1.2e-13 51.1 0.0 2.1 1 1 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 CDK98815.1 - 2.7e-05 24.2 0.1 0.00013 22.0 0.1 2.0 1 1 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 CDK98815.1 - 0.00096 18.8 0.3 0.022 14.3 0.0 3.0 2 2 0 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 CDK98815.1 - 0.037 13.4 0.0 0.14 11.6 0.0 1.9 1 1 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Radical_SAM PF04055.21 CDK98815.1 - 0.076 13.4 0.0 0.82 10.0 0.0 2.5 2 1 0 2 2 2 0 Radical SAM superfamily cNMP_binding PF00027.29 CDK98816.1 - 3.2e-14 52.8 0.0 5e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 CDK98816.1 - 1.2e-12 47.6 0.2 8.6e-12 44.9 0.0 2.3 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain GntR PF00392.21 CDK98816.1 - 0.00022 20.8 0.0 0.00093 18.8 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Crp PF00325.20 CDK98816.1 - 0.0037 16.9 0.0 0.041 13.5 0.0 2.5 2 0 0 2 2 2 1 Bacterial regulatory proteins, crp family Rrf2 PF02082.20 CDK98816.1 - 0.022 15.1 0.0 0.058 13.8 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator T2SS-T3SS_pil_N PF13629.6 CDK98817.1 - 8.2e-20 70.3 1.5 1.4e-19 69.6 1.5 1.4 1 0 0 1 1 1 1 Pilus formation protein N terminal region TPR_2 PF07719.17 CDK98818.1 - 7.3e-14 50.7 19.5 0.0035 17.3 0.1 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDK98818.1 - 1.1e-09 37.8 15.0 5e-06 26.1 0.6 4.6 4 1 1 5 5 5 3 TPR repeat TPR_17 PF13431.6 CDK98818.1 - 5.6e-09 35.8 8.2 0.00019 21.6 0.3 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDK98818.1 - 1.3e-08 35.0 35.8 0.0035 18.0 1.3 6.1 1 1 5 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDK98818.1 - 5.1e-08 33.4 41.9 8.5e-05 23.1 5.2 4.1 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDK98818.1 - 2.1e-07 31.4 30.3 0.00063 20.2 5.2 4.1 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 CDK98818.1 - 6.7e-07 28.9 7.6 0.32 10.9 0.0 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDK98818.1 - 0.00091 19.5 28.5 1.1 9.6 7.1 4.9 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDK98818.1 - 0.0014 18.7 5.0 1.4 9.3 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDK98818.1 - 0.003 17.7 24.0 0.42 10.8 5.5 4.6 2 2 1 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 CDK98818.1 - 0.0032 18.0 7.2 0.012 16.2 3.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 CDK98818.1 - 0.035 14.4 15.4 3.2 8.2 0.3 4.2 1 1 2 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDK98818.1 - 0.1 13.3 16.2 1.8 9.3 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDK98818.1 - 3.4 7.9 6.0 15 5.9 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 CDK98818.1 - 5.8 6.8 12.6 2 8.3 0.3 3.8 2 2 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal T2SSF PF00482.23 CDK98819.1 - 1.9e-18 66.6 2.0 1.9e-18 66.6 2.0 2.4 2 1 1 3 3 3 1 Type II secretion system (T2SS), protein F Peptidase_M50 PF02163.22 CDK98819.1 - 2.4 7.4 4.2 7.3 5.8 2.7 2.2 1 1 0 1 1 1 0 Peptidase family M50 T2SSF PF00482.23 CDK98820.1 - 5.2e-20 71.7 1.0 5.2e-20 71.7 1.0 2.8 3 0 0 3 3 3 1 Type II secretion system (T2SS), protein F T2SSE PF00437.20 CDK98821.1 - 5.9e-81 271.5 0.1 8.5e-81 271.0 0.1 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 CDK98821.1 - 0.00021 21.7 0.1 0.00079 19.8 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 CDK98821.1 - 0.00043 19.7 0.0 0.001 18.5 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 CDK98821.1 - 0.0026 17.1 0.0 0.0047 16.2 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin ABC_tran PF00005.27 CDK98821.1 - 0.0031 18.0 0.0 0.012 16.2 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_28 PF13521.6 CDK98821.1 - 0.0082 16.4 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 CDK98821.1 - 0.0088 15.4 0.1 0.019 14.3 0.1 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_23 PF13476.6 CDK98821.1 - 0.012 16.2 0.6 0.02 15.4 0.6 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDK98821.1 - 0.017 15.4 0.0 0.04 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDK98821.1 - 0.018 14.8 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_2 PF07724.14 CDK98821.1 - 0.024 14.8 0.0 0.062 13.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDK98821.1 - 0.032 14.5 0.0 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CDK98821.1 - 0.036 13.7 0.0 0.08 12.5 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain FH2 PF02181.23 CDK98821.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Formin Homology 2 Domain CbiA PF01656.23 CDK98821.1 - 0.13 12.3 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Septin PF00735.18 CDK98821.1 - 0.17 11.1 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Septin CBP_BcsQ PF06564.12 CDK98822.1 - 8.8e-09 35.2 0.3 1.4e-08 34.6 0.3 1.2 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ AAA_31 PF13614.6 CDK98822.1 - 0.00049 20.1 0.0 0.0057 16.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain ParA PF10609.9 CDK98822.1 - 0.0021 17.6 0.0 0.004 16.7 0.0 1.4 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase Peptidase_S66 PF02016.15 CDK98822.1 - 0.023 14.8 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain CbiA PF01656.23 CDK98822.1 - 0.042 13.9 0.0 0.059 13.4 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Pilus_CpaD PF09476.10 CDK98823.1 - 2e-36 125.6 0.0 2.5e-36 125.3 0.0 1.1 1 0 0 1 1 1 1 Pilus biogenesis CpaD protein (pilus_cpaD) Secretin PF00263.21 CDK98824.1 - 1.6e-36 125.5 0.8 2.5e-36 124.9 0.8 1.3 1 0 0 1 1 1 1 Bacterial type II and III secretion system protein T2SS-T3SS_pil_N PF13629.6 CDK98824.1 - 3.4e-15 55.5 0.4 8.4e-15 54.3 0.4 1.7 1 0 0 1 1 1 1 Pilus formation protein N terminal region BON PF04972.17 CDK98824.1 - 0.0042 17.4 0.0 0.011 16.0 0.0 1.8 1 0 0 1 1 1 1 BON domain RcpC PF16976.5 CDK98825.1 - 1.8e-29 102.1 1.2 1.8e-29 102.1 1.2 2.0 2 0 0 2 2 2 1 Flp pilus assembly protein RcpC/CpaB SAF PF08666.12 CDK98825.1 - 1.1e-08 35.6 0.0 4.3e-08 33.7 0.0 2.0 2 0 0 2 2 2 1 SAF domain ChapFlgA PF13144.6 CDK98825.1 - 0.015 15.3 0.0 0.048 13.7 0.0 1.8 2 0 0 2 2 2 0 Chaperone for flagella basal body P-ring formation DUF4330 PF14221.6 CDK98825.1 - 0.1 12.8 0.9 0.18 12.0 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4330) Peptidase_A24 PF01478.18 CDK98826.1 - 4e-09 36.8 17.8 4e-09 36.8 17.8 1.8 2 0 0 2 2 2 1 Type IV leader peptidase family Flp_Fap PF04964.14 CDK98827.1 - 9.8e-19 66.9 4.5 1.1e-18 66.7 3.1 1.7 1 1 1 2 2 2 1 Flp/Fap pilin component Tad PF13400.6 CDK98828.1 - 4.8e-11 42.8 7.8 4.8e-11 42.8 7.8 2.1 2 0 0 2 2 2 1 Putative Flp pilus-assembly TadE/G-like VWA PF00092.28 CDK98828.1 - 1.7e-08 34.9 0.1 0.095 12.9 0.0 4.3 3 1 0 3 3 3 2 von Willebrand factor type A domain VWA_2 PF13519.6 CDK98828.1 - 2e-05 25.2 0.0 0.0037 17.9 0.0 3.3 4 0 0 4 4 4 1 von Willebrand factor type A domain TadE PF07811.12 CDK98829.1 - 8.3e-08 32.4 3.7 2e-07 31.2 3.7 1.7 1 0 0 1 1 1 1 TadE-like protein Flp_Fap PF04964.14 CDK98829.1 - 0.065 13.1 0.3 0.12 12.2 0.3 1.5 1 0 0 1 1 1 0 Flp/Fap pilin component TadE PF07811.12 CDK98830.1 - 7.6e-12 45.3 4.6 1.7e-11 44.2 4.6 1.6 1 0 0 1 1 1 1 TadE-like protein Tad PF13400.6 CDK98830.1 - 0.011 16.0 1.1 0.011 16.0 1.1 1.8 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like CoA_transf_3 PF02515.17 CDK98831.1 - 8e-138 459.5 0.3 9.1e-138 459.4 0.3 1.0 1 0 0 1 1 1 1 CoA-transferase family III DUF4010 PF13194.6 CDK98831.1 - 0.022 14.5 0.3 0.033 13.9 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) Acyl-CoA_dh_N PF02771.16 CDK98832.1 - 7.1e-35 120.1 0.1 1.1e-34 119.4 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 CDK98832.1 - 2.3e-27 96.1 1.3 3.6e-27 95.4 1.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CDK98832.1 - 6.6e-23 80.7 0.0 1.1e-22 80.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CDK98832.1 - 4e-07 30.4 0.8 6.9e-07 29.6 0.8 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Response_reg PF00072.24 CDK98833.1 - 1.1e-25 90.0 0.1 2.8e-25 88.7 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain SpoIIE PF07228.12 CDK98833.1 - 1.2e-19 71.0 0.2 2.2e-19 70.2 0.2 1.4 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Response_reg PF00072.24 CDK98834.1 - 3.3e-25 88.4 0.0 3.7e-25 88.3 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain B12-binding PF02310.19 CDK98834.1 - 0.029 14.4 0.1 0.038 14.0 0.1 1.1 1 0 0 1 1 1 0 B12 binding domain Hpt PF01627.23 CDK98835.1 - 2.4e-06 27.7 3.1 2.4e-06 27.7 3.1 1.6 2 0 0 2 2 2 1 Hpt domain GGDEF PF00990.21 CDK98836.1 - 2.4e-40 137.9 0.0 6.3e-40 136.6 0.0 1.7 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain Response_reg PF00072.24 CDK98836.1 - 8.4e-22 77.5 0.0 1.6e-21 76.6 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain SBP_bac_3 PF00497.20 CDK98837.1 - 2.5e-22 79.4 0.0 3.3e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1 PF09084.11 CDK98837.1 - 0.13 12.2 0.0 4.7 7.1 0.0 2.1 2 0 0 2 2 2 0 NMT1/THI5 like Response_reg PF00072.24 CDK98838.1 - 9.7e-45 151.3 3.2 5.6e-24 84.5 0.1 2.8 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.26 CDK98838.1 - 3.8e-31 107.9 0.0 8.2e-31 106.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98838.1 - 6.3e-18 64.6 2.9 1.3e-17 63.6 0.1 3.2 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.23 CDK98838.1 - 1.5e-10 41.2 1.5 1.5e-10 41.2 1.5 4.1 5 0 0 5 5 5 1 Hpt domain HAMP PF00672.25 CDK98838.1 - 0.00044 20.6 2.2 0.0035 17.7 0.0 3.4 3 0 0 3 3 3 1 HAMP domain TFR_dimer PF04253.15 CDK98838.1 - 0.039 14.1 0.1 0.13 12.3 0.1 2.0 1 0 0 1 1 1 0 Transferrin receptor-like dimerisation domain HATPase_c_2 PF13581.6 CDK98838.1 - 0.1 12.6 0.2 0.59 10.1 0.0 2.4 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 CDK98838.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Seryl_tRNA_N PF02403.22 CDK98838.1 - 2.1 8.6 5.3 0.96 9.7 1.9 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ABC_tran PF00005.27 CDK98839.1 - 1.8e-24 86.8 0.0 3.1e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98839.1 - 3.5e-05 23.8 2.2 0.17 11.7 0.1 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK98839.1 - 0.00028 20.4 0.2 0.51 9.7 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_membrane PF00664.23 CDK98839.1 - 0.00069 19.3 1.6 0.00069 19.3 1.6 1.9 2 0 0 2 2 2 1 ABC transporter transmembrane region AAA_29 PF13555.6 CDK98839.1 - 0.015 15.1 0.5 0.032 14.0 0.5 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 CDK98839.1 - 0.032 13.9 0.1 0.084 12.6 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDK98839.1 - 0.041 14.3 0.3 0.15 12.5 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 CDK98839.1 - 0.075 13.5 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CDK98839.1 - 0.19 11.4 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain DUF4191 PF13829.6 CDK98839.1 - 5.4 6.3 5.7 0.34 10.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) ABC_tran PF00005.27 CDK98840.1 - 1.5e-22 80.6 0.0 2.5e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98840.1 - 7e-06 26.1 2.2 0.041 13.7 0.4 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK98840.1 - 2.1e-05 24.1 0.0 0.036 13.5 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDK98840.1 - 0.00046 19.9 0.0 0.035 13.8 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_membrane PF00664.23 CDK98840.1 - 0.0012 18.6 1.6 0.0012 18.6 1.6 1.5 2 0 0 2 2 2 1 ABC transporter transmembrane region AAA_30 PF13604.6 CDK98840.1 - 0.019 14.7 0.1 0.039 13.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDK98840.1 - 0.022 15.2 0.1 0.062 13.7 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 CDK98840.1 - 0.063 12.6 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.6 CDK98840.1 - 0.069 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDK98840.1 - 0.12 12.9 0.1 0.19 12.2 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CDK98840.1 - 0.2 11.3 0.0 0.29 10.8 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Acyl_transf_1 PF00698.21 CDK98841.1 - 3.3e-36 125.4 0.3 4.9e-36 124.8 0.3 1.2 1 0 0 1 1 1 1 Acyl transferase domain NMO PF03060.15 CDK98841.1 - 1.3e-11 44.5 3.9 3.6e-11 43.0 3.9 1.6 1 1 0 1 1 1 1 Nitronate monooxygenase ketoacyl-synt PF00109.26 CDK98842.1 - 0 1551.8 18.3 1.8e-89 299.7 0.2 7.3 7 1 0 7 7 7 6 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CDK98842.1 - 3.4e-227 739.9 27.6 1.7e-41 140.9 0.5 6.6 6 0 0 6 6 6 6 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 CDK98842.1 - 3.8e-99 329.9 5.5 1.1e-48 165.6 0.0 3.5 4 0 0 4 4 4 2 KR domain PP-binding PF00550.25 CDK98842.1 - 1.3e-88 291.3 23.8 8.6e-14 51.7 0.1 8.0 8 0 0 8 8 7 7 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CDK98842.1 - 1.8e-86 286.0 0.0 4.7e-18 65.7 0.0 6.5 6 0 0 6 6 6 6 Ketoacyl-synthetase C-terminal extension PS-DH PF14765.6 CDK98842.1 - 9.6e-53 179.3 10.3 8.8e-49 166.3 1.3 3.7 3 1 0 3 3 3 3 Polyketide synthase dehydratase ECH_1 PF00378.20 CDK98842.1 - 4.3e-40 137.6 0.0 2.1e-39 135.3 0.0 2.1 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Thiolase_N PF00108.23 CDK98842.1 - 6.3e-31 107.7 18.5 4.9e-06 26.1 0.0 7.1 7 1 0 7 7 7 6 Thiolase, N-terminal domain adh_short PF00106.25 CDK98842.1 - 2.7e-23 82.5 0.6 1.3e-13 50.9 0.9 2.5 2 0 0 2 2 2 2 short chain dehydrogenase Methyltransf_12 PF08242.12 CDK98842.1 - 1.6e-15 57.6 0.0 7.8e-15 55.4 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 CDK98842.1 - 5.5e-14 52.3 1.3 9.1e-09 35.2 1.3 2.5 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase 3Beta_HSD PF01073.19 CDK98842.1 - 3.5e-08 32.8 0.0 0.0032 16.5 0.0 2.4 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_23 PF13489.6 CDK98842.1 - 4.1e-08 33.2 0.0 9.1e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 CDK98842.1 - 5.5e-07 29.3 0.7 0.015 14.8 0.4 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Methyltransf_25 PF13649.6 CDK98842.1 - 1.6e-06 28.7 0.0 7.6e-06 26.5 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain ECH_2 PF16113.5 CDK98842.1 - 7.4e-06 25.7 0.0 1.3e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Methyltransf_11 PF08241.12 CDK98842.1 - 3.3e-05 24.5 0.0 0.00014 22.4 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDK98842.1 - 0.00053 19.8 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain GDP_Man_Dehyd PF16363.5 CDK98842.1 - 0.0098 15.3 0.0 1.6 8.1 0.0 2.3 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CDK98842.1 - 0.06 12.5 0.4 0.24 10.5 0.4 1.9 1 1 0 1 1 1 0 Male sterility protein Polysacc_synt_2 PF02719.15 CDK98842.1 - 0.091 11.9 0.0 0.3 10.2 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein FMO-like PF00743.19 CDK98843.1 - 5.6e-48 163.7 0.0 7.1e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CDK98843.1 - 2.6e-20 72.9 0.0 6.3e-16 58.5 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDK98843.1 - 2e-12 47.0 0.0 1.5e-09 37.5 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CDK98843.1 - 2.7e-08 33.4 0.5 1.1e-06 28.0 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CDK98843.1 - 1.7e-05 24.6 5.3 0.035 13.7 0.0 3.1 2 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDK98843.1 - 4.8e-05 23.4 4.2 0.12 12.3 0.3 3.5 4 0 0 4 4 4 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CDK98843.1 - 0.00021 21.4 0.3 0.0045 17.2 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CDK98843.1 - 0.0045 17.5 3.7 0.07 13.7 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CDK98843.1 - 0.04 13.2 1.4 0.071 12.3 0.3 1.8 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.6 CDK98843.1 - 0.49 10.9 1.2 6.1 7.3 0.1 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding ketoacyl-synt PF00109.26 CDK98844.1 - 0 1366.9 5.6 2.9e-91 305.5 0.0 5.6 5 0 0 5 5 5 5 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CDK98844.1 - 1.7e-186 608.7 25.9 1e-40 138.4 0.8 5.7 5 0 0 5 5 5 5 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 CDK98844.1 - 2.4e-100 328.9 16.2 1.2e-16 60.8 0.2 7.9 7 0 0 7 7 7 7 Phosphopantetheine attachment site PS-DH PF14765.6 CDK98844.1 - 4.6e-96 321.6 4.2 2.4e-48 164.9 0.8 2.8 2 0 0 2 2 2 2 Polyketide synthase dehydratase KR PF08659.10 CDK98844.1 - 7.4e-94 312.7 4.9 2.7e-47 161.0 0.2 3.2 3 0 0 3 3 3 2 KR domain AMP-binding PF00501.28 CDK98844.1 - 2.8e-89 299.6 0.0 4.9e-89 298.8 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme KAsynt_C_assoc PF16197.5 CDK98844.1 - 5.3e-71 236.2 0.0 1.1e-15 58.1 0.0 5.7 5 0 0 5 5 5 5 Ketoacyl-synthetase C-terminal extension Condensation PF00668.20 CDK98844.1 - 6.8e-66 222.8 0.0 9.8e-66 222.3 0.0 1.2 1 0 0 1 1 1 1 Condensation domain Thioesterase PF00975.20 CDK98844.1 - 1.2e-32 113.9 0.0 2.7e-32 112.8 0.0 1.6 1 0 0 1 1 1 1 Thioesterase domain Thiolase_N PF00108.23 CDK98844.1 - 2.7e-30 105.6 11.7 1.1e-05 24.9 0.1 5.5 5 0 0 5 5 5 5 Thiolase, N-terminal domain adh_short PF00106.25 CDK98844.1 - 2.3e-23 82.7 0.4 4.2e-12 45.9 0.0 2.6 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDK98844.1 - 6.6e-15 55.3 0.1 1.4e-07 31.3 0.0 3.1 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CDK98844.1 - 5.5e-11 42.4 0.5 0.00036 20.1 0.0 2.6 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 CDK98844.1 - 8.5e-10 39.5 0.4 4.2e-09 37.3 0.4 2.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GDP_Man_Dehyd PF16363.5 CDK98844.1 - 0.0019 17.7 0.0 0.74 9.2 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CDK98844.1 - 0.069 12.3 0.0 3.7 6.6 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 CDK98844.1 - 0.21 10.6 0.0 3.3 6.6 0.0 2.1 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CDK98844.1 - 8.8 6.2 8.1 1.5 8.7 0.1 3.6 3 0 0 3 3 3 0 NAD(P)H-binding Band_7 PF01145.25 CDK98845.1 - 1.8e-20 73.7 0.0 2.5e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Ofd1_CTDD PF10637.9 CDK98845.1 - 0.053 12.9 0.0 0.089 12.1 0.0 1.4 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term Peripla_BP_6 PF13458.6 CDK98846.1 - 3.5e-34 119.0 5.7 5.5e-34 118.3 5.7 1.2 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.28 CDK98846.1 - 5.9e-21 75.0 0.0 8.1e-21 74.5 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_5 PF13433.6 CDK98846.1 - 1e-06 28.0 0.0 2.8e-06 26.6 0.0 1.7 1 1 0 1 1 1 1 Periplasmic binding protein domain LppC PF04348.13 CDK98846.1 - 0.0018 17.2 0.2 0.0026 16.6 0.2 1.2 1 0 0 1 1 1 1 LppC putative lipoprotein DUF1616 PF07760.11 CDK98846.1 - 0.15 11.4 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) DUF697 PF05128.12 CDK98848.1 - 2.5e-16 59.8 0.8 3.2e-16 59.4 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF697) EcsC PF12787.7 CDK98848.1 - 0.067 12.9 2.1 0.41 10.3 0.0 2.4 1 1 0 2 2 2 0 EcsC protein family Mso1_Sec1_bdg PF14475.6 CDK98848.1 - 0.087 12.4 0.6 12 5.5 0.0 2.2 2 0 0 2 2 2 0 Sec1-binding region of Mso1 Acyl_transf_1 PF00698.21 CDK98849.1 - 1.1e-34 120.4 0.0 1.4e-34 120.1 0.0 1.0 1 0 0 1 1 1 1 Acyl transferase domain SBP_bac_3 PF00497.20 CDK98850.1 - 8.2e-40 136.6 0.0 1.1e-39 136.2 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 CDK98850.1 - 0.0014 18.8 0.0 0.0039 17.4 0.0 1.8 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SDF PF00375.18 CDK98851.1 - 1e-71 242.0 36.5 1.3e-71 241.7 36.5 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family PP-binding PF00550.25 CDK98852.1 - 4.5e-06 26.9 0.1 6.1e-06 26.5 0.1 1.3 1 1 0 1 1 1 1 Phosphopantetheine attachment site HTH_33 PF13592.6 CDK98852.1 - 0.048 13.3 0.0 4.1 7.1 0.0 2.4 2 1 0 2 2 2 0 Winged helix-turn helix DUF1866 PF08952.11 CDK98852.1 - 0.05 13.5 0.1 0.071 12.9 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1866) Asn_synthase PF00733.21 CDK98853.1 - 5.7e-70 236.7 0.1 7.5e-70 236.4 0.1 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CDK98853.1 - 5.3e-47 158.8 0.0 1.8e-46 157.0 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDK98853.1 - 1.7e-40 138.3 0.0 7.3e-40 136.3 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CDK98853.1 - 0.0039 16.7 0.0 0.0066 15.9 0.0 1.2 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 CDK98853.1 - 0.0057 15.8 0.0 0.0087 15.2 0.0 1.2 1 0 0 1 1 1 1 NAD synthase ECH_1 PF00378.20 CDK98854.1 - 6.1e-46 156.8 0.0 6.9e-46 156.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDK98854.1 - 1.6e-17 64.1 0.0 1.7e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ketoacyl-synt PF00109.26 CDK98855.1 - 2e-26 93.1 1.1 2.8e-26 92.6 1.1 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CDK98855.1 - 2.9e-24 85.4 0.4 2.9e-24 85.4 0.4 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CDK98855.1 - 5.1e-05 22.8 0.8 5.1e-05 22.8 0.8 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain MreD PF04093.12 CDK98855.1 - 0.04 14.0 0.1 0.062 13.4 0.1 1.2 1 0 0 1 1 1 0 rod shape-determining protein MreD PP-binding PF00550.25 CDK98856.1 - 0.00027 21.2 0.4 0.00032 21.0 0.4 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site HMG_CoA_synt_C PF08540.10 CDK98857.1 - 2.5e-16 60.1 0.0 2e-10 40.7 0.0 2.1 1 1 1 2 2 2 2 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 CDK98857.1 - 1.3e-11 44.7 0.0 2.3e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Chal_sti_synt_N PF00195.19 CDK98857.1 - 0.0001 21.8 0.1 0.00017 21.1 0.1 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III PF08545.10 CDK98857.1 - 0.0002 21.1 0.2 0.00041 20.1 0.2 1.6 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 CDK98857.1 - 0.058 12.8 0.0 0.12 11.7 0.1 1.4 2 0 0 2 2 2 0 Thiolase, N-terminal domain ACP_syn_III_C PF08541.10 CDK98857.1 - 0.13 12.4 0.1 0.3 11.3 0.1 1.5 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal p450 PF00067.22 CDK98858.1 - 1.1e-27 96.9 0.0 3.7e-25 88.6 0.0 3.0 1 1 0 1 1 1 1 Cytochrome P450 Methyltransf_21 PF05050.12 CDK98859.1 - 5e-14 52.7 0.0 2.2e-13 50.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase FkbM domain V_cholerae_RfbT PF05575.11 CDK98859.1 - 0.00017 21.0 0.0 0.0044 16.4 0.0 2.1 2 0 0 2 2 2 1 Vibrio cholerae RfbT protein MTS PF05175.14 CDK98859.1 - 0.051 13.1 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 CDK98859.1 - 0.078 13.7 0.0 0.18 12.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CDK98859.1 - 0.083 12.7 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Metallophos PF00149.28 CDK98860.1 - 3.2e-14 53.9 0.0 6.9e-14 52.8 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDK98860.1 - 8e-08 32.6 0.0 4.3e-05 23.8 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain DUF2219 PF09982.9 CDK98861.1 - 7.5e-85 284.7 0.3 9.4e-85 284.3 0.3 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2219) PepSY_2 PF13670.6 CDK98862.1 - 1e-09 38.3 0.0 1.2e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain Lambda_tail_I PF06805.12 CDK98862.1 - 0.013 15.8 0.0 0.023 15.0 0.0 1.6 1 1 0 1 1 1 0 Bacteriophage lambda tail assembly protein I DUF3309 PF11752.8 CDK98865.1 - 7.5e-24 83.5 13.8 8.2e-24 83.4 13.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3309) DUF1772 PF08592.11 CDK98865.1 - 0.18 12.1 3.3 0.18 12.1 3.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) NEMP PF10225.9 CDK98865.1 - 2.1 7.9 6.0 2.3 7.8 6.0 1.1 1 0 0 1 1 1 0 NEMP family DUF2207 PF09972.9 CDK98865.1 - 8.2 5.1 8.8 8.3 5.0 8.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CsbD PF05532.12 CDK98866.1 - 5.8e-16 58.1 7.6 6.2e-16 58.0 7.6 1.0 1 0 0 1 1 1 1 CsbD-like Phasin PF05597.11 CDK98866.1 - 0.021 14.8 0.3 0.022 14.7 0.3 1.0 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) OmpA PF00691.20 CDK98867.1 - 1.1e-16 61.0 0.0 1.8e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 OmpA family Gly-zipper_YMGG PF13441.6 CDK98868.1 - 7.9e-08 31.9 17.0 1.1e-07 31.4 17.0 1.3 1 0 0 1 1 1 1 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 CDK98868.1 - 0.0002 21.3 41.8 0.0017 18.3 24.6 2.0 1 1 1 2 2 2 2 Glycine zipper TraT PF05818.12 CDK98868.1 - 0.024 14.3 7.1 0.027 14.1 7.1 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Gly-zipper_OmpA PF13436.6 CDK98868.1 - 0.036 13.9 28.5 0.036 13.9 26.3 1.9 1 1 1 2 2 2 0 Glycine-zipper domain Rick_17kDa_Anti PF05433.15 CDK98868.1 - 0.076 12.9 26.5 0.14 12.1 25.8 1.8 1 1 2 3 3 3 0 Glycine zipper 2TM domain Romo1 PF10247.9 CDK98868.1 - 0.082 13.3 9.2 1.2 9.5 0.5 2.2 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 YtxH PF12732.7 CDK98868.1 - 0.16 12.5 1.0 0.16 12.5 1.0 2.1 2 0 0 2 2 2 0 YtxH-like protein DUF3482 PF11981.8 CDK98868.1 - 0.94 8.8 15.0 1 8.7 15.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) DUF1269 PF06897.12 CDK98868.1 - 1.1 9.6 15.5 0.8 10.0 13.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1269) OmpA PF00691.20 CDK98869.1 - 7.6e-20 71.1 0.6 1.5e-19 70.1 0.6 1.4 2 0 0 2 2 2 1 OmpA family Pilus_CpaD PF09476.10 CDK98869.1 - 0.0021 17.8 1.4 0.003 17.3 1.4 1.2 1 0 0 1 1 1 1 Pilus biogenesis CpaD protein (pilus_cpaD) GcrA PF07750.11 CDK98869.1 - 0.2 12.1 1.9 0.29 11.5 1.9 1.3 1 0 0 1 1 1 0 GcrA cell cycle regulator HATPase_c PF02518.26 CDK98870.1 - 2.9e-25 89.0 0.0 6.4e-25 87.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98870.1 - 6.1e-08 32.6 0.1 6.1e-08 32.6 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CDK98870.1 - 0.00056 19.8 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 GHKL domain PAS_9 PF13426.7 CDK98870.1 - 0.003 17.8 0.0 0.007 16.6 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDK98870.1 - 0.057 13.7 0.1 0.17 12.2 0.1 1.8 1 0 0 1 1 1 0 PAS fold HATPase_c_3 PF13589.6 CDK98870.1 - 0.078 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Vir_act_alpha_C PF10400.9 CDK98870.1 - 1.9 9.2 9.4 2.8 8.7 0.3 2.9 2 1 0 2 2 2 0 Virulence activator alpha C-term CheB_methylest PF01339.17 CDK98871.1 - 1.3e-52 178.0 0.1 2.4e-52 177.1 0.1 1.5 1 0 0 1 1 1 1 CheB methylesterase CheR PF01739.18 CDK98871.1 - 2.2e-51 174.2 0.0 3.4e-51 173.5 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain PAS_10 PF13596.6 CDK98871.1 - 6.7e-28 97.4 0.0 2.5e-26 92.3 0.0 2.8 2 0 0 2 2 2 1 PAS domain CheR_N PF03705.15 CDK98871.1 - 8.2e-13 47.9 0.1 1.7e-12 46.9 0.1 1.5 1 0 0 1 1 1 1 CheR methyltransferase, all-alpha domain PAS PF00989.25 CDK98871.1 - 4.2e-06 26.7 0.0 2.3 8.2 0.0 3.7 3 0 0 3 3 3 1 PAS fold CENP-F_leu_zip PF10473.9 CDK98871.1 - 0.00011 22.3 14.4 0.0002 21.4 14.4 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PAS_4 PF08448.10 CDK98871.1 - 0.00012 22.3 0.2 1.3 9.3 0.1 3.6 3 0 0 3 3 3 1 PAS fold AIP3 PF03915.13 CDK98871.1 - 0.00027 20.2 1.6 0.00041 19.6 1.6 1.2 1 0 0 1 1 1 1 Actin interacting protein 3 Rootletin PF15035.6 CDK98871.1 - 0.00028 21.0 5.6 0.00047 20.2 5.6 1.3 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion ATG16 PF08614.11 CDK98871.1 - 0.00073 19.8 12.6 0.0013 19.0 12.6 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 CDK98871.1 - 0.0021 17.6 12.7 0.0038 16.8 12.7 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 5 Leu_zip PF15294.6 CDK98871.1 - 0.0031 17.1 7.6 0.0052 16.3 7.6 1.3 1 0 0 1 1 1 1 Leucine zipper Spc7 PF08317.11 CDK98871.1 - 0.0034 16.3 14.8 0.0055 15.6 14.8 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Snapin_Pallidin PF14712.6 CDK98871.1 - 0.0074 16.7 10.0 0.026 14.9 10.0 2.0 1 0 0 1 1 1 1 Snapin/Pallidin HMMR_N PF15905.5 CDK98871.1 - 0.0096 15.4 13.5 0.017 14.6 13.5 1.3 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Exonuc_VII_L PF02601.15 CDK98871.1 - 0.011 15.3 1.5 0.018 14.6 1.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3552 PF12072.8 CDK98871.1 - 0.021 14.3 15.5 0.037 13.4 15.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Med30 PF11315.8 CDK98871.1 - 0.023 14.9 7.4 0.031 14.5 5.6 2.0 2 0 0 2 2 2 0 Mediator complex subunit 30 DUF3584 PF12128.8 CDK98871.1 - 0.028 12.0 7.2 0.042 11.4 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) WEMBL PF05701.11 CDK98871.1 - 0.028 13.1 8.1 0.043 12.5 8.1 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Atg14 PF10186.9 CDK98871.1 - 0.029 13.5 4.5 0.041 13.0 4.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4795 PF16043.5 CDK98871.1 - 0.031 13.9 6.1 0.061 12.9 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) GAS PF13851.6 CDK98871.1 - 0.032 13.6 13.0 0.074 12.4 12.7 1.7 2 0 0 2 2 1 0 Growth-arrest specific micro-tubule binding KxDL PF10241.9 CDK98871.1 - 0.034 14.4 13.2 0.8 10.0 2.2 2.8 1 1 1 2 2 2 0 Uncharacterized conserved protein Methyltransf_12 PF08242.12 CDK98871.1 - 0.038 14.7 0.0 0.34 11.7 0.0 2.6 1 1 0 1 1 1 0 Methyltransferase domain HOOK PF05622.12 CDK98871.1 - 0.041 12.0 11.8 0.064 11.4 11.8 1.1 1 0 0 1 1 1 0 HOOK protein DUF4407 PF14362.6 CDK98871.1 - 0.046 13.1 1.4 0.073 12.4 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Methyltransf_25 PF13649.6 CDK98871.1 - 0.05 14.3 0.2 1.2 9.9 0.0 3.0 2 1 0 2 2 1 0 Methyltransferase domain Laminin_II PF06009.12 CDK98871.1 - 0.055 13.5 6.7 0.12 12.4 6.7 1.6 1 0 0 1 1 1 0 Laminin Domain II Seryl_tRNA_N PF02403.22 CDK98871.1 - 0.058 13.6 7.8 0.14 12.4 7.8 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain HIP1_clath_bdg PF16515.5 CDK98871.1 - 0.064 13.9 13.2 0.21 12.2 13.2 1.9 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Methyltransf_23 PF13489.6 CDK98871.1 - 0.072 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain IFT57 PF10498.9 CDK98871.1 - 0.11 11.4 10.3 0.17 10.8 10.3 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Baculo_gp64 PF03273.13 CDK98871.1 - 0.19 10.5 1.1 0.44 9.3 1.0 1.5 1 1 1 2 2 2 0 Baculovirus gp64 envelope glycoprotein family FapA PF03961.13 CDK98871.1 - 0.22 10.1 6.4 0.38 9.3 6.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_13 PF13166.6 CDK98871.1 - 0.22 10.1 6.2 0.31 9.6 6.2 1.1 1 0 0 1 1 1 0 AAA domain DUF812 PF05667.11 CDK98871.1 - 0.24 10.2 9.6 0.36 9.6 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) UPF0242 PF06785.11 CDK98871.1 - 0.29 11.2 12.4 0.54 10.3 12.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 CDK98871.1 - 0.37 10.0 12.7 0.81 8.9 12.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) NRBF2 PF08961.10 CDK98871.1 - 0.39 10.3 7.1 0.74 9.4 7.1 1.4 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator ADIP PF11559.8 CDK98871.1 - 0.39 10.8 14.8 0.72 9.9 14.8 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TerB_C PF15615.6 CDK98871.1 - 0.39 11.0 9.1 6.7 7.0 9.8 2.5 3 0 0 3 3 2 0 TerB-C domain Fusion_gly PF00523.18 CDK98871.1 - 0.47 8.6 2.8 0.78 7.9 2.8 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 LMBR1 PF04791.16 CDK98871.1 - 0.48 9.3 2.2 0.74 8.7 2.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein OmpH PF03938.14 CDK98871.1 - 0.54 10.6 11.2 1.1 9.6 11.2 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Fmp27_WPPW PF10359.9 CDK98871.1 - 0.54 9.0 7.0 0.84 8.4 7.0 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain ZapB PF06005.12 CDK98871.1 - 0.67 10.4 22.5 1.1e+02 3.4 22.5 2.5 1 1 0 1 1 1 0 Cell division protein ZapB XRCC4 PF06632.12 CDK98871.1 - 0.9 8.3 8.8 1.4 7.7 8.8 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 TMPIT PF07851.13 CDK98871.1 - 0.99 8.6 6.9 1.6 7.9 6.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein Sec20 PF03908.13 CDK98871.1 - 1.2 9.1 5.4 3 7.8 5.4 1.7 1 0 0 1 1 1 0 Sec20 V_ATPase_I PF01496.19 CDK98871.1 - 1.3 6.9 9.3 1.9 6.3 9.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1189 PF06691.11 CDK98871.1 - 1.3 8.5 2.5 2.1 7.8 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Mod_r PF07200.13 CDK98871.1 - 1.8 8.7 14.1 3.7 7.6 12.4 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF1664 PF07889.12 CDK98871.1 - 1.9 8.5 9.0 4.6 7.3 8.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 CDK98871.1 - 1.9 9.0 17.6 3.7 8.1 17.6 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Prominin PF05478.11 CDK98871.1 - 2.3 6.1 4.8 3.3 5.5 4.8 1.1 1 0 0 1 1 1 0 Prominin DivIC PF04977.15 CDK98871.1 - 2.3 8.0 15.6 2.5 7.9 7.5 2.6 1 1 1 2 2 2 0 Septum formation initiator DUF2203 PF09969.9 CDK98871.1 - 2.9 8.6 5.4 7.6 7.3 5.4 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) PilO PF04350.13 CDK98871.1 - 3.5 7.8 8.1 1 9.5 4.3 1.9 1 1 1 2 2 2 0 Pilus assembly protein, PilO DUF745 PF05335.13 CDK98871.1 - 4.6 6.9 11.1 9.8 5.8 11.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF4200 PF13863.6 CDK98871.1 - 5.6 7.4 14.7 13 6.2 14.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) UPF0449 PF15136.6 CDK98871.1 - 6.5 7.3 14.7 30 5.2 13.6 2.4 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 TMF_TATA_bd PF12325.8 CDK98871.1 - 7.1 6.9 18.1 14 5.9 18.1 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Syntaxin-6_N PF09177.11 CDK98871.1 - 8.1 7.1 11.3 46 4.7 11.3 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Cation_ATPase_C PF00689.21 CDK98872.1 - 7.6e-47 159.4 0.1 7.6e-47 159.4 0.1 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CDK98872.1 - 1.1e-43 148.8 2.8 1.1e-43 148.8 2.8 3.1 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CDK98872.1 - 3.9e-24 86.1 5.9 1e-23 84.7 5.9 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CDK98872.1 - 2.7e-16 59.0 0.0 5.2e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CDK98872.1 - 3.5e-09 36.8 0.4 1.6e-05 24.8 0.7 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDK98872.1 - 2.3e-08 34.0 0.0 2.7e-07 30.6 0.0 2.4 1 1 0 1 1 1 1 Cation transport ATPase (P-type) HAD PF12710.7 CDK98872.1 - 2.2e-05 24.9 0.1 5.8e-05 23.6 0.1 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_transf_36 PF06165.11 CDK98873.1 - 4.6e-156 517.6 0.0 1.9e-77 260.1 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase family 36 Glyco_hydro_36 PF17167.4 CDK98873.1 - 2.4e-115 385.6 0.0 3.2e-115 385.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain Glycoamylase PF10091.9 CDK98873.1 - 6.2e-13 48.8 0.0 1.5e-12 47.6 0.0 1.6 2 0 0 2 2 2 1 Putative glucoamylase DUF3131 PF11329.8 CDK98873.1 - 0.055 12.5 0.1 0.092 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3131) GDE_C PF06202.14 CDK98873.1 - 0.17 10.8 0.0 0.34 9.8 0.0 1.4 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase Glyco_trans_2_3 PF13632.6 CDK98873.1 - 0.55 10.1 6.5 13 5.6 5.2 3.3 2 1 0 2 2 2 0 Glycosyl transferase family group 2 DUF3096 PF11295.8 CDK98874.1 - 1.3e-17 63.1 13.9 1.6e-17 62.9 13.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3096) SLATT_6 PF18169.1 CDK98874.1 - 0.0063 16.1 2.1 0.0069 16.0 2.1 1.0 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain 6 DUF308 PF03729.13 CDK98874.1 - 0.01 16.2 9.7 0.025 14.9 9.7 1.6 1 1 0 1 1 1 0 Short repeat of unknown function (DUF308) Wzy_C PF04932.15 CDK98874.1 - 0.39 10.3 3.9 0.45 10.1 3.9 1.0 1 0 0 1 1 1 0 O-Antigen ligase Mac PF12464.8 CDK98876.1 - 0.0035 17.6 0.1 1.5 9.1 0.0 2.2 2 0 0 2 2 2 2 Maltose acetyltransferase Gp5_C PF06715.12 CDK98876.1 - 0.24 11.6 3.2 1.1 9.6 3.5 1.9 1 1 0 1 1 1 0 Gp5 C-terminal repeat (3 copies) BON PF04972.17 CDK98879.1 - 3.4e-18 65.7 0.9 3.4e-18 65.7 0.9 1.5 2 0 0 2 2 2 1 BON domain PRC PF05239.16 CDK98880.1 - 4.8e-12 45.8 0.3 6.1e-12 45.5 0.3 1.2 1 0 0 1 1 1 1 PRC-barrel domain Response_reg PF00072.24 CDK98881.1 - 7.3e-10 39.0 0.1 8.6e-10 38.8 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain FleQ PF06490.11 CDK98881.1 - 0.00061 20.1 0.0 0.00074 19.9 0.0 1.0 1 0 0 1 1 1 1 Flagellar regulatory protein FleQ Rossmann-like PF10727.9 CDK98881.1 - 0.04 13.8 0.6 0.049 13.5 0.6 1.1 1 0 0 1 1 1 0 Rossmann-like domain CheR PF01739.18 CDK98882.1 - 1.3e-54 184.7 0.0 2e-54 184.0 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheB_methylest PF01339.17 CDK98882.1 - 2.3e-52 177.1 0.1 4.6e-52 176.2 0.1 1.5 1 0 0 1 1 1 1 CheB methylesterase Response_reg PF00072.24 CDK98882.1 - 1.6e-44 150.7 0.0 2.3e-25 88.9 0.0 3.0 2 0 0 2 2 2 2 Response regulator receiver domain PAS_10 PF13596.6 CDK98882.1 - 2.2e-22 79.6 0.0 6.5e-22 78.1 0.0 1.9 1 0 0 1 1 1 1 PAS domain HATPase_c PF02518.26 CDK98882.1 - 1.1e-19 71.0 0.0 2.3e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GerE PF00196.19 CDK98882.1 - 6.8e-16 57.6 0.0 1.5e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family CheR_N PF03705.15 CDK98882.1 - 8.8e-10 38.2 0.5 2.9e-09 36.5 0.6 1.9 2 0 0 2 2 1 1 CheR methyltransferase, all-alpha domain Sigma70_r4_2 PF08281.12 CDK98882.1 - 1.4e-07 31.1 1.7 3.7e-07 29.7 0.0 2.7 4 0 0 4 4 2 1 Sigma-70, region 4 PAS_4 PF08448.10 CDK98882.1 - 4.8e-07 30.0 2.2 6.3e-06 26.4 0.3 3.3 3 0 0 3 3 3 1 PAS fold HisKA PF00512.25 CDK98882.1 - 2.2e-06 27.6 1.2 2.2e-06 27.6 1.2 3.3 2 1 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Sigma70_r4 PF04545.16 CDK98882.1 - 0.00051 19.5 0.0 0.0015 18.0 0.0 1.8 1 0 0 1 1 1 1 Sigma-70, region 4 PAS PF00989.25 CDK98882.1 - 0.00086 19.3 0.0 1.4 8.9 0.0 2.5 2 0 0 2 2 2 2 PAS fold HTH_23 PF13384.6 CDK98882.1 - 0.00088 19.0 0.0 0.0031 17.3 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain Fez1 PF06818.15 CDK98882.1 - 0.002 18.6 1.0 0.0042 17.6 1.0 1.5 1 0 0 1 1 1 1 Fez1 Sigma70_ECF PF07638.11 CDK98882.1 - 0.0062 16.5 0.0 0.0062 16.5 0.0 2.1 2 0 0 2 2 1 1 ECF sigma factor Methyltransf_25 PF13649.6 CDK98882.1 - 0.011 16.5 0.4 0.93 10.2 0.0 3.7 2 1 0 2 2 2 0 Methyltransferase domain HTH_28 PF13518.6 CDK98882.1 - 0.021 14.9 0.1 0.12 12.5 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Methyltransf_12 PF08242.12 CDK98882.1 - 0.05 14.4 0.0 0.42 11.4 0.0 2.7 2 1 0 2 2 1 0 Methyltransferase domain Mod_r PF07200.13 CDK98882.1 - 0.17 12.0 9.6 0.54 10.4 9.6 1.8 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein IFT57 PF10498.9 CDK98882.1 - 0.28 10.1 7.3 0.45 9.4 7.3 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Occludin_ELL PF07303.13 CDK98882.1 - 0.34 11.7 1.5 0.86 10.4 1.5 1.6 1 0 0 1 1 1 0 Occludin homology domain TolA_bind_tri PF16331.5 CDK98882.1 - 0.34 11.0 10.6 0.74 9.9 6.1 2.9 1 1 1 2 2 2 0 TolA binding protein trimerisation LMBR1 PF04791.16 CDK98882.1 - 0.57 9.0 2.6 0.83 8.5 2.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein HTH_20 PF12840.7 CDK98882.1 - 0.81 9.8 6.8 4.6 7.4 0.0 4.6 4 0 0 4 4 4 0 Helix-turn-helix domain TMPIT PF07851.13 CDK98882.1 - 0.84 8.8 2.3 1.3 8.2 2.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 CDK98882.1 - 1.2 9.2 2.8 3 7.9 2.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Golgin_A5 PF09787.9 CDK98882.1 - 1.3 8.4 11.1 2.2 7.7 11.1 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DegS PF05384.11 CDK98882.1 - 2 7.9 9.3 7 6.1 9.3 1.9 1 1 0 1 1 1 0 Sensor protein DegS UPF0242 PF06785.11 CDK98882.1 - 3.2 7.8 8.6 6.2 6.9 8.6 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 CDK98882.1 - 3.5 5.4 4.6 5 4.9 4.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 CDK98882.1 - 4 6.2 12.0 7.4 5.4 12.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3450 PF11932.8 CDK98882.1 - 4.6 6.5 9.3 10 5.3 9.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Seryl_tRNA_N PF02403.22 CDK98882.1 - 7.4 6.9 7.7 21 5.4 7.7 1.8 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Phage_TAC_8 PF10666.9 CDK98883.1 - 0.013 15.7 0.0 1.1 9.6 0.0 2.2 1 1 1 2 2 2 0 Phage tail assembly chaperone protein Gp14 ()A118 Vhr1 PF04001.13 CDK98883.1 - 0.035 14.4 0.0 0.048 13.9 0.0 1.2 1 0 0 1 1 1 0 Transcription factor Vhr1 DUF2244 PF10003.9 CDK98884.1 - 0.3 10.7 0.9 0.34 10.6 0.0 1.6 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) VIT PF08487.10 CDK98885.1 - 6.6e-09 36.0 0.0 1.3e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain DUF2135 PF09906.9 CDK98885.1 - 3.3e-06 27.3 0.0 7.7e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2135) TPR_14 PF13428.6 CDK98885.1 - 6.6e-06 26.5 6.2 0.84 10.6 0.2 4.6 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDK98885.1 - 2e-05 25.2 0.4 2e-05 25.2 0.4 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDK98885.1 - 7.2e-05 22.9 0.4 0.00028 21.0 0.4 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDK98885.1 - 0.0015 19.0 3.3 0.55 10.8 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat VIT_2 PF13757.6 CDK98885.1 - 0.16 11.9 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain TPR_15 PF13429.6 CDK98885.1 - 0.17 11.1 4.2 0.28 10.4 4.2 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDK98885.1 - 0.94 10.3 5.7 2.6 8.9 0.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Response_reg PF00072.24 CDK98886.1 - 5e-11 42.8 0.0 6.8e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 CDK98886.1 - 5.7e-09 35.4 0.0 1e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family FLYWCH_N PF15423.6 CDK98886.1 - 0.045 13.9 0.0 0.072 13.2 0.0 1.2 1 0 0 1 1 1 0 FLYWCH-type zinc finger-containing protein Sigma70_r4_2 PF08281.12 CDK98886.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 Snf7 PF03357.21 CDK98887.1 - 0.037 13.6 4.9 0.04 13.5 4.9 1.1 1 0 0 1 1 1 0 Snf7 Sec20 PF03908.13 CDK98887.1 - 0.17 11.9 0.3 0.25 11.3 0.3 1.3 1 0 0 1 1 1 0 Sec20 ISG65-75 PF11727.8 CDK98887.1 - 2.5 7.3 10.7 2.9 7.0 10.7 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Njmu-R1 PF15053.6 CDK98889.1 - 0.058 12.5 0.3 0.13 11.3 0.2 1.5 1 1 1 2 2 2 0 Mjmu-R1-like protein family RF3_C PF16658.5 CDK98889.1 - 0.064 13.1 0.1 0.12 12.2 0.1 1.4 1 1 0 1 1 1 0 Class II release factor RF3, C-terminal domain ATPase PF06745.13 CDK98890.1 - 5.5e-79 264.8 0.0 1.7e-43 148.7 0.0 2.5 3 0 0 3 3 3 2 KaiC AAA_25 PF13481.6 CDK98890.1 - 1e-17 64.3 7.9 3.2e-12 46.4 0.2 2.9 3 0 0 3 3 3 2 AAA domain DnaB_C PF03796.15 CDK98890.1 - 1.1e-11 44.5 0.0 5.5e-06 25.9 0.0 2.3 2 0 0 2 2 2 2 DnaB-like helicase C terminal domain RecA PF00154.21 CDK98890.1 - 6.1e-09 35.7 0.1 0.0038 16.7 0.0 2.7 2 0 0 2 2 2 2 recA bacterial DNA recombination protein Rad51 PF08423.11 CDK98890.1 - 1.9e-08 33.9 0.5 0.0004 19.7 0.0 3.2 3 0 0 3 3 3 2 Rad51 IstB_IS21 PF01695.17 CDK98890.1 - 2.4e-08 33.9 1.1 0.0017 18.1 0.0 3.0 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_16 PF13191.6 CDK98890.1 - 2.7e-07 31.1 6.7 0.0059 17.0 0.1 3.3 2 2 0 3 3 3 2 AAA ATPase domain DUF2075 PF09848.9 CDK98890.1 - 1.3e-06 27.9 0.0 0.0071 15.6 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 CDK98890.1 - 1.7e-06 28.5 0.3 0.0046 17.4 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDK98890.1 - 8.7e-05 22.8 1.3 0.22 11.8 0.0 3.2 3 1 0 3 3 3 2 AAA domain AAA_24 PF13479.6 CDK98890.1 - 0.00013 21.7 0.0 0.33 10.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 CDK98890.1 - 0.00026 20.9 4.8 0.096 12.6 2.1 3.3 2 2 0 2 2 2 1 NACHT domain PAXNEB PF05625.11 CDK98890.1 - 0.00041 19.6 2.1 0.13 11.3 0.0 3.0 3 0 0 3 3 3 2 PAXNEB protein AAA_30 PF13604.6 CDK98890.1 - 0.00047 19.9 0.5 0.2 11.3 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CDK98890.1 - 0.00065 20.1 0.3 0.71 10.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.9 CDK98890.1 - 0.00095 18.2 0.3 0.25 10.2 0.0 2.4 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_28 PF13521.6 CDK98890.1 - 0.0013 19.0 0.1 2.9 8.1 0.0 3.1 3 1 0 3 3 3 2 AAA domain GvpD PF07088.11 CDK98890.1 - 0.0013 17.4 0.1 1 7.9 0.0 2.3 2 0 0 2 2 2 2 GvpD gas vesicle protein AAA_5 PF07728.14 CDK98890.1 - 0.0014 18.6 0.0 2.8 7.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDK98890.1 - 0.0041 17.3 1.4 4.3 7.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain ATP-synt_ab PF00006.25 CDK98890.1 - 0.0046 16.6 0.4 1.2 8.8 0.1 2.9 2 1 0 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_7 PF12775.7 CDK98890.1 - 0.02 14.4 0.0 3.5 7.1 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_11 PF13086.6 CDK98890.1 - 0.022 14.6 0.0 2.8 7.6 0.1 2.4 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CDK98890.1 - 0.026 14.5 0.0 2.2 8.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain MEDS PF14417.6 CDK98890.1 - 0.027 14.3 1.0 1.5 8.6 0.1 3.1 3 0 0 3 3 3 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain RuvB_N PF05496.12 CDK98890.1 - 0.093 12.5 1.4 17 5.2 0.0 3.2 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_29 PF13555.6 CDK98890.1 - 0.1 12.4 0.5 12 5.7 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain cobW PF02492.19 CDK98890.1 - 0.12 12.0 0.1 12 5.4 0.0 3.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 CDK98890.1 - 0.12 11.7 2.9 0.43 9.9 0.1 2.9 3 0 0 3 3 3 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 CDK98890.1 - 0.16 11.3 0.4 7.8 5.7 0.0 2.6 3 0 0 3 3 3 0 Zeta toxin RNA_helicase PF00910.22 CDK98890.1 - 0.22 12.0 0.0 25 5.3 0.0 2.4 2 0 0 2 2 2 0 RNA helicase KaiB PF07689.12 CDK98891.1 - 6.7e-13 48.2 0.0 7.4e-13 48.0 0.0 1.0 1 0 0 1 1 1 1 KaiB domain HATPase_c PF02518.26 CDK98892.1 - 4.3e-25 88.4 0.0 6.8e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98892.1 - 3.5e-12 46.2 0.1 1e-11 44.7 0.0 1.8 1 1 1 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 CDK98892.1 - 2e-07 31.2 0.3 4.6e-07 30.1 0.3 1.6 1 0 0 1 1 1 1 PAS fold HATPase_c_5 PF14501.6 CDK98892.1 - 1.6e-05 24.8 0.0 3e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 CDK98892.1 - 6.2e-05 23.0 0.0 0.00026 20.9 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 CDK98892.1 - 0.093 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Phasin_2 PF09361.10 CDK98893.1 - 4.8e-20 71.7 5.0 6.8e-20 71.2 5.0 1.2 1 0 0 1 1 1 1 Phasin protein DUF2529 PF10740.9 CDK98893.1 - 0.079 12.6 0.3 0.091 12.4 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) Catalase PF00199.19 CDK98896.1 - 7.9e-175 581.5 0.0 1e-174 581.1 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CDK98896.1 - 2.2e-21 75.8 0.2 4.2e-21 74.9 0.2 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 CDK98896.1 - 2.3e-13 50.0 1.0 4.2e-13 49.2 1.0 1.4 1 0 0 1 1 1 1 C-terminal domain found in long catalases MctB PF11382.8 CDK98896.1 - 0.0029 17.4 0.1 0.0055 16.4 0.1 1.3 1 0 0 1 1 1 1 Copper transport outer membrane protein, MctB DJ-1_PfpI PF01965.24 CDK98896.1 - 0.011 15.5 0.2 0.018 14.9 0.2 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Chal_sti_synt_N PF00195.19 CDK98897.1 - 1.3e-22 80.4 0.9 1.8e-21 76.6 1.1 2.0 2 0 0 2 2 2 1 Chalcone and stilbene synthases, N-terminal domain FAE1_CUT1_RppA PF08392.12 CDK98897.1 - 1.4e-15 57.4 0.1 2.3e-15 56.7 0.1 1.2 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein Chal_sti_synt_C PF02797.15 CDK98897.1 - 3.3e-15 56.4 0.0 5.4e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain ACP_syn_III_C PF08541.10 CDK98897.1 - 8.5e-08 32.3 0.0 1.4e-06 28.4 0.0 2.6 2 1 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 CDK98897.1 - 4.6e-07 29.6 1.7 1.6e-06 27.9 2.1 1.7 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_C PF02803.18 CDK98897.1 - 0.015 14.9 0.0 5.1 6.8 0.0 2.6 2 0 0 2 2 2 0 Thiolase, C-terminal domain CbiC PF02570.15 CDK98897.1 - 0.052 13.2 0.0 0.084 12.5 0.0 1.3 1 0 0 1 1 1 0 Precorrin-8X methylmutase ICMT PF04140.14 CDK98898.1 - 1e-23 83.6 0.4 1e-23 83.6 0.4 1.5 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CDK98898.1 - 1.3e-05 25.6 1.4 2e-05 24.9 1.0 1.6 1 1 0 1 1 1 1 Phospholipid methyltransferase Lyase_1 PF00206.20 CDK98899.1 - 1.4e-109 366.3 0.0 1.9e-109 365.9 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 CDK98899.1 - 6.6e-24 84.1 0.0 6.6e-24 84.1 0.0 1.9 2 0 0 2 2 2 1 Fumarase C C-terminus Aconitase PF00330.20 CDK98900.1 - 2.4e-183 610.4 0.0 3e-183 610.0 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CDK98900.1 - 1.1e-44 151.9 0.0 1.7e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain TERF2_RBM PF16772.5 CDK98902.1 - 0.12 11.8 0.0 0.5 9.8 0.0 1.9 2 0 0 2 2 2 0 Telomeric repeat-binding factor 2 Rap1-binding motif Pkinase PF00069.25 CDK98903.1 - 3.6e-07 29.8 0.0 1.2e-06 28.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Adenylsucc_synt PF00709.21 CDK98904.1 - 3.3e-170 566.6 0.0 3.7e-170 566.4 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase YAcAr PF10686.9 CDK98904.1 - 0.031 14.2 0.2 7.5 6.6 0.1 2.8 2 0 0 2 2 2 0 YspA, cpYpsA-related SLOG family tRNA-synt_His PF13393.6 CDK98905.1 - 8.4e-85 284.7 0.2 9.9e-85 284.5 0.2 1.0 1 0 0 1 1 1 1 Histidyl-tRNA synthetase CobW_C PF07683.14 CDK98905.1 - 0.17 11.9 0.0 0.72 9.8 0.0 2.0 2 0 0 2 2 2 0 Cobalamin synthesis protein cobW C-terminal domain MCPsignal PF00015.21 CDK98906.1 - 6.3e-38 130.3 27.3 6.3e-38 130.3 27.3 3.3 1 1 2 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain CZB PF13682.6 CDK98906.1 - 1.1e-10 41.8 0.2 2.5e-10 40.6 0.2 1.6 1 0 0 1 1 1 1 Chemoreceptor zinc-binding domain Laminin_II PF06009.12 CDK98906.1 - 0.0026 17.8 20.1 0.0088 16.1 4.8 2.7 2 1 0 2 2 2 2 Laminin Domain II BLOC1_2 PF10046.9 CDK98906.1 - 0.012 15.9 6.6 4.1 7.8 0.3 4.0 2 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NRBF2_MIT PF17169.4 CDK98906.1 - 0.015 15.5 0.1 0.042 14.1 0.1 1.7 1 0 0 1 1 1 0 MIT domain of nuclear receptor-binding factor 2 NPV_P10 PF05531.12 CDK98906.1 - 0.039 14.4 10.6 2.4 8.7 0.3 3.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 CDK98906.1 - 0.067 13.2 15.2 0.84 9.7 1.7 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 CDK98906.1 - 2.5 8.4 21.2 2 8.7 1.4 4.8 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) GIT1_C PF12205.8 CDK98906.1 - 3.2 7.9 13.7 3.4 7.8 3.3 3.1 1 1 2 3 3 3 0 G protein-coupled receptor kinase-interacting protein 1 C term Syntaxin_2 PF14523.6 CDK98906.1 - 4.1 7.8 9.2 9 6.7 0.3 4.0 3 2 2 5 5 5 0 Syntaxin-like protein WXG100 PF06013.12 CDK98906.1 - 6 7.2 31.5 0.42 10.9 9.4 4.4 2 1 1 4 4 4 0 Proteins of 100 residues with WXG 2-Hacid_dh_C PF02826.19 CDK98907.1 - 1.4e-57 194.0 0.1 6.1e-57 191.8 0.0 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDK98907.1 - 2e-34 118.1 0.9 1.3e-33 115.5 0.2 2.5 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 CDK98907.1 - 1.9e-09 37.2 0.0 1.8e-08 34.0 0.0 2.3 2 0 0 2 2 2 1 ACT domain IlvN PF07991.12 CDK98907.1 - 0.012 15.2 0.0 0.14 11.7 0.0 2.3 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Phage_spike PF18715.1 CDK98907.1 - 0.13 12.3 0.1 0.58 10.3 0.0 2.1 2 0 0 2 2 2 0 Phage spike trimer Aminotran_5 PF00266.19 CDK98908.1 - 0.006 15.6 0.0 0.011 14.7 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V CitMHS PF03600.16 CDK98909.1 - 5.3e-40 137.5 37.9 2e-26 92.9 7.3 2.1 2 0 0 2 2 2 2 Citrate transporter TrkA_C PF02080.21 CDK98909.1 - 2.4e-18 65.7 0.1 2.6e-08 33.6 0.0 2.5 2 0 0 2 2 2 2 TrkA-C domain Castor_Poll_mid PF06241.12 CDK98909.1 - 0.00047 20.1 0.0 0.18 11.8 0.0 2.4 2 0 0 2 2 2 2 Castor and Pollux, part of voltage-gated ion channel DctM PF06808.12 CDK98909.1 - 0.001 18.0 19.0 0.001 18.0 19.0 2.8 2 2 0 2 2 2 1 Tripartite ATP-independent periplasmic transporter, DctM component CxxCxxCC PF03692.15 CDK98910.1 - 4.6e-07 30.4 1.0 7.7e-07 29.7 1.0 1.3 1 0 0 1 1 1 1 Putative zinc- or iron-chelating domain PhzC-PhzF PF02567.16 CDK98911.1 - 2.1e-55 188.2 0.0 1.6e-54 185.3 0.0 1.9 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein DUF4190 PF13828.6 CDK98911.1 - 0.067 13.0 0.5 0.17 11.7 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4190) Glyco_transf_25 PF01755.17 CDK98912.1 - 1.2e-08 35.1 0.0 5.3e-08 33.0 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Phos_pyr_kin PF08543.12 CDK98913.1 - 7.1e-91 304.0 0.1 8e-91 303.8 0.1 1.0 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CDK98913.1 - 4.1e-06 26.3 0.2 6.3e-06 25.7 0.2 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 CDK98913.1 - 0.089 12.2 5.4 0.31 10.5 5.4 2.0 1 1 0 1 1 1 0 Carbohydrate kinase DUF294 PF03445.13 CDK98914.1 - 1.2e-37 128.7 0.0 2e-37 128.1 0.0 1.3 1 0 0 1 1 1 1 Putative nucleotidyltransferase DUF294 DUF294_C PF10335.9 CDK98914.1 - 3.2e-25 88.6 0.1 1.1e-24 86.8 0.1 1.9 2 0 0 2 2 2 1 Putative nucleotidyltransferase substrate binding domain CBS PF00571.28 CDK98914.1 - 5.2e-21 74.9 1.1 2.5e-10 40.6 0.1 2.5 2 0 0 2 2 2 2 CBS domain DUF485 PF04341.12 CDK98916.1 - 4.4e-36 122.7 0.2 5e-36 122.5 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF485 PhoLip_ATPase_C PF16212.5 CDK98916.1 - 0.049 13.4 0.1 0.055 13.2 0.1 1.0 1 0 0 1 1 1 0 Phospholipid-translocating P-type ATPase C-terminal SSF PF00474.17 CDK98917.1 - 1.4e-106 356.8 38.9 2.5e-106 356.0 38.9 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family DUF2818 PF10993.8 CDK98917.1 - 0.13 12.8 6.4 0.15 12.7 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2818) HTH_Tnp_IS630 PF01710.16 CDK98918.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK98918.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK98918.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK98918.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK98918.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK98918.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDK98919.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK98919.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain Glyoxalase_3 PF13468.6 CDK98920.1 - 9.4e-41 139.8 0.1 1.2e-40 139.5 0.1 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Melittin PF01372.17 CDK98920.1 - 0.1 12.6 0.1 6.8 6.9 0.0 2.7 2 0 0 2 2 2 0 Melittin BacA PF02673.18 CDK98921.1 - 2.2e-78 263.5 14.4 2.5e-78 263.3 14.4 1.0 1 0 0 1 1 1 1 Bacitracin resistance protein BacA YfhO PF09586.10 CDK98921.1 - 0.0026 16.1 0.7 0.0026 16.1 0.7 1.4 1 1 0 1 1 1 1 Bacterial membrane protein YfhO DUF5058 PF16481.5 CDK98921.1 - 0.016 14.9 5.5 0.027 14.2 0.0 2.7 2 2 1 3 3 3 0 Domain of unknown function (DUF5058) Methyltransf_23 PF13489.6 CDK98922.1 - 2.2e-16 60.2 0.0 2.8e-16 59.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK98922.1 - 7.3e-10 39.4 0.0 1.3e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK98922.1 - 8.3e-07 29.6 0.0 1.3e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK98922.1 - 9.4e-07 29.5 0.0 5.5e-06 27.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.12 CDK98922.1 - 0.00096 18.8 0.0 0.0013 18.4 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_31 PF13847.6 CDK98922.1 - 0.0022 17.8 0.0 0.004 16.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain DUF3419 PF11899.8 CDK98922.1 - 0.032 13.4 0.0 0.076 12.2 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3419) FtsJ PF01728.19 CDK98922.1 - 0.033 14.3 0.0 0.044 13.9 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 CDK98922.1 - 0.038 13.7 0.0 0.054 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 CDK98922.1 - 0.078 12.4 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB GT87 PF09594.10 CDK98923.1 - 8.5e-05 22.4 29.7 8.5e-05 22.4 29.7 3.2 2 1 1 3 3 3 1 Glycosyltransferase family 87 CPP1-like PF11833.8 CDK98923.1 - 0.91 9.1 9.1 7.8 6.1 3.5 2.9 2 1 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like UPF0014 PF03649.13 CDK98923.1 - 3.6 6.9 17.6 1.8 7.9 7.1 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0014) AAA_31 PF13614.6 CDK98924.1 - 3.8e-20 72.5 0.9 3.4e-12 46.6 0.3 2.2 1 1 1 2 2 2 2 AAA domain MipZ PF09140.11 CDK98924.1 - 7.1e-15 55.0 1.1 1.4e-12 47.5 1.0 2.3 1 1 0 1 1 1 1 ATPase MipZ CbiA PF01656.23 CDK98924.1 - 3.6e-14 52.9 0.0 5.4e-14 52.3 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 CDK98924.1 - 4.6e-12 45.9 2.5 1.9e-10 40.6 0.3 2.3 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 CDK98924.1 - 3.5e-09 36.5 0.5 2.1e-05 24.2 0.1 2.1 1 1 1 2 2 2 2 Cellulose biosynthesis protein BcsQ VirC1 PF07015.11 CDK98924.1 - 1.5e-08 34.3 0.3 8.6e-08 31.8 0.3 1.9 1 1 0 1 1 1 1 VirC1 protein ArsA_ATPase PF02374.15 CDK98924.1 - 7e-06 25.4 0.6 1.7e-05 24.2 0.1 1.8 3 0 0 3 3 3 1 Anion-transporting ATPase MeaB PF03308.16 CDK98924.1 - 1.8e-05 23.9 0.2 4.1e-05 22.7 0.2 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_NifH PF00142.18 CDK98924.1 - 0.0068 15.9 0.1 0.017 14.6 0.0 1.6 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CLP1_P PF16575.5 CDK98924.1 - 0.025 14.4 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ATP_bind_1 PF03029.17 CDK98924.1 - 0.052 13.3 0.0 0.12 12.2 0.0 1.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein LpxK PF02606.14 CDK98924.1 - 0.16 11.1 1.5 0.32 10.0 0.3 2.0 2 0 0 2 2 2 0 Tetraacyldisaccharide-1-P 4'-kinase CopD PF05425.13 CDK98925.1 - 2.4e-07 31.1 2.8 2.4e-07 31.1 2.8 2.0 2 0 0 2 2 2 1 Copper resistance protein D NUDIX PF00293.28 CDK98926.1 - 1.2e-10 41.5 0.1 1.7e-10 41.0 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain PALP PF00291.25 CDK98927.1 - 1.1e-71 241.7 0.7 1.2e-71 241.6 0.7 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.20 CDK98928.1 - 1.1e-32 112.8 0.0 7.2e-18 65.1 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain VWA_2 PF13519.6 CDK98929.1 - 2.7e-08 34.4 0.0 6.2e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CDK98929.1 - 3.6e-08 33.9 0.0 7.6e-08 32.8 0.0 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 CDK98929.1 - 0.0036 17.3 0.0 0.014 15.3 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain DUF1194 PF06707.11 CDK98929.1 - 0.047 12.9 0.2 0.11 11.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1194) Rotamase PF00639.21 CDK98929.1 - 0.14 13.1 0.5 0.54 11.2 0.0 2.1 2 0 0 2 2 2 0 PPIC-type PPIASE domain AAA_5 PF07728.14 CDK98930.1 - 2.2e-36 124.9 0.0 3.2e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) CbbQ_C PF08406.10 CDK98930.1 - 4.9e-31 106.8 0.7 9.5e-31 105.9 0.3 1.7 2 0 0 2 2 2 1 CbbQ/NirQ/NorQ C-terminal Mg_chelatase PF01078.21 CDK98930.1 - 1.8e-06 27.5 0.0 0.0022 17.4 0.0 2.1 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDK98930.1 - 2e-05 24.5 0.0 3.4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDK98930.1 - 0.00047 19.7 0.0 0.00072 19.1 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region Sigma54_activat PF00158.26 CDK98930.1 - 0.0039 16.9 0.0 0.02 14.6 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 CDK98930.1 - 0.0043 17.5 0.0 0.0078 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CDK98930.1 - 0.0047 17.4 0.0 0.0073 16.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_6 PF12774.7 CDK98930.1 - 0.005 15.9 0.0 0.0085 15.1 0.0 1.3 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region RNA_helicase PF00910.22 CDK98930.1 - 0.0061 16.9 0.0 0.0095 16.3 0.0 1.3 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 CDK98930.1 - 0.009 16.0 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain MCM PF00493.23 CDK98930.1 - 0.009 15.1 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain TsaE PF02367.17 CDK98930.1 - 0.017 15.1 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 CDK98930.1 - 0.017 15.1 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDK98930.1 - 0.019 15.3 0.0 0.035 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDK98930.1 - 0.024 14.6 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain SRP54 PF00448.22 CDK98930.1 - 0.031 13.9 0.1 0.052 13.2 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Rad17 PF03215.15 CDK98930.1 - 0.039 13.9 0.0 0.059 13.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain RuvB_N PF05496.12 CDK98930.1 - 0.061 13.1 0.0 0.27 11.0 0.0 1.9 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDK98930.1 - 0.066 13.3 0.0 0.18 11.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_19 PF13245.6 CDK98930.1 - 0.074 13.4 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CDK98930.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 CDK98930.1 - 0.17 10.9 0.0 0.29 10.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_11 PF13086.6 CDK98930.1 - 0.22 11.3 0.0 0.33 10.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain COX1 PF00115.20 CDK98931.1 - 4.1e-81 273.1 66.8 5.1e-81 272.7 66.8 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I TMEM51 PF15345.6 CDK98931.1 - 0.066 13.0 0.1 0.095 12.5 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Cytochrom_C PF00034.21 CDK98932.1 - 1.4e-07 32.5 0.0 2.1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CDK98932.1 - 1e-05 25.8 0.1 1.7e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III FixO PF02433.15 CDK98932.1 - 0.0073 15.8 0.0 0.013 14.9 0.0 1.4 2 0 0 2 2 2 1 Cytochrome C oxidase, mono-heme subunit/FixO DUF3687 PF12459.8 CDK98932.1 - 0.15 11.6 0.3 0.26 10.8 0.3 1.3 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein ptaRNA1_toxin PF12703.7 CDK98934.1 - 0.075 13.1 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 Toxin of toxin-antitoxin type 1 system AphA_like PF14557.6 CDK98935.1 - 6.5e-24 84.6 0.0 8.2e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 Putative AphA-like transcriptional regulator FUR PF01475.19 CDK98936.1 - 5.1e-18 65.4 0.0 5.6e-18 65.2 0.0 1.0 1 0 0 1 1 1 1 Ferric uptake regulator family MarR_2 PF12802.7 CDK98936.1 - 0.0028 17.5 0.1 0.0047 16.8 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 CDK98936.1 - 0.01 15.9 0.1 0.017 15.1 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.6 CDK98936.1 - 0.037 14.1 0.0 0.1 12.7 0.0 1.8 1 1 0 1 1 1 0 Winged helix-turn helix DUF4734 PF15881.5 CDK98936.1 - 0.051 13.7 0.0 0.071 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4734) TrmB PF01978.19 CDK98936.1 - 0.14 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Cadherin_5 PF17892.1 CDK98937.1 - 5.4e-76 250.8 31.5 3.6e-27 94.2 3.9 5.2 5 0 0 5 5 5 3 Cadherin-like domain Big_9 PF17963.1 CDK98937.1 - 8e-37 125.9 40.4 4.9e-14 52.9 11.0 9.5 7 3 1 8 8 8 4 Bacterial Ig domain Cadherin_4 PF17803.1 CDK98937.1 - 2e-20 73.2 41.0 1.7e-09 38.2 6.1 9.9 8 3 2 10 10 10 4 Bacterial cadherin-like domain HemolysinCabind PF00353.19 CDK98937.1 - 7.3e-12 45.0 54.9 2.8e-08 33.6 8.5 6.1 6 0 0 6 6 6 4 RTX calcium-binding nonapeptide repeat (4 copies) FecR PF04773.13 CDK98937.1 - 2e-06 28.3 1.6 2.3e-05 24.9 0.1 3.5 2 1 0 2 2 2 1 FecR protein BNR PF02012.20 CDK98937.1 - 8 6.9 6.6 2.1 8.7 1.5 3.1 2 0 0 2 2 2 0 BNR/Asp-box repeat HlyD_3 PF13437.6 CDK98938.1 - 1e-17 64.8 1.0 1.1e-14 55.0 0.4 2.6 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CDK98938.1 - 2.5e-10 39.9 5.8 1.4e-08 34.2 0.1 2.4 1 1 0 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD PF00529.20 CDK98938.1 - 4.8e-08 32.8 0.0 6.7e-08 32.3 0.0 1.4 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl PF00364.22 CDK98938.1 - 0.0015 18.4 1.5 0.26 11.2 0.0 2.9 2 1 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDK98938.1 - 0.0041 16.9 8.3 0.0089 15.8 0.2 3.4 3 0 0 3 3 3 1 Biotin-lipoyl like Csm1_N PF18504.1 CDK98938.1 - 0.015 15.6 10.5 0.043 14.2 0.8 3.7 3 1 1 4 4 4 0 Csm1 N-terminal domain ABC_tran_CTD PF16326.5 CDK98938.1 - 0.41 10.9 15.6 0.19 12.0 2.5 3.1 2 1 1 3 3 3 0 ABC transporter C-terminal domain FAM76 PF16046.5 CDK98938.1 - 0.85 8.9 6.0 1.2 8.4 6.0 1.1 1 0 0 1 1 1 0 FAM76 protein TMF_DNA_bd PF12329.8 CDK98938.1 - 2.4 8.2 6.7 1.5 8.8 4.3 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 CDK98938.1 - 2.6 6.8 10.5 9.6 5.0 9.7 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein MscS_porin PF12795.7 CDK98938.1 - 5.6 6.4 11.3 5 6.6 3.7 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain ABC_tran PF00005.27 CDK98939.1 - 3e-29 102.3 0.0 6.4e-29 101.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDK98939.1 - 2.2e-18 66.9 1.4 3e-18 66.5 1.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDK98939.1 - 9.4e-09 35.0 0.0 8.6e-07 28.6 0.0 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDK98939.1 - 6.2e-05 22.9 0.1 0.094 12.5 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Mg_chelatase PF01078.21 CDK98939.1 - 0.0044 16.4 0.0 0.012 15.0 0.0 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CDK98939.1 - 0.026 14.7 1.5 0.92 9.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 CDK98939.1 - 0.13 12.0 0.1 0.28 11.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CDK98939.1 - 0.63 10.4 0.0 0.63 10.4 0.0 2.9 3 1 0 3 3 3 0 AAA ATPase domain OEP PF02321.18 CDK98940.1 - 6.3e-21 75.0 15.3 5.2e-11 42.7 4.9 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein DUF2721 PF11026.8 CDK98941.1 - 6.2 6.7 11.0 14 5.6 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) PGPGW PF09656.10 CDK98941.1 - 8.2 6.0 18.1 3.6 7.2 0.4 3.7 3 0 0 3 3 3 0 Putative transmembrane protein (PGPGW) DUF2116 PF09889.9 CDK98942.1 - 0.12 12.4 1.6 0.21 11.6 1.6 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Nuc_deoxyrib_tr PF05014.15 CDK98944.1 - 8.5e-48 161.7 0.0 1e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase Nuc_deoxyri_tr2 PF15891.5 CDK98944.1 - 0.0012 19.1 0.0 0.0017 18.6 0.0 1.2 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like Cation_efflux PF01545.21 CDK98945.1 - 5.1e-15 55.7 15.6 1.4e-13 51.1 15.6 2.0 1 1 0 1 1 1 1 Cation efflux family Ribosomal_L13 PF00572.18 CDK98946.1 - 7.9e-50 168.3 0.0 9.4e-50 168.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 DUF3659 PF12396.8 CDK98946.1 - 0.067 13.1 0.1 0.34 10.9 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3659) Ribosomal_S9 PF00380.19 CDK98947.1 - 1.1e-46 158.3 0.0 1.4e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 TPR_2 PF07719.17 CDK98949.1 - 8e-45 147.4 10.6 6.3e-07 29.0 0.2 9.9 10 0 0 10 10 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 CDK98949.1 - 1.8e-35 119.3 0.2 1e-07 31.4 0.1 8.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDK98949.1 - 2.5e-34 117.7 25.9 4.2e-09 36.9 3.1 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDK98949.1 - 3.6e-34 114.1 0.0 0.00016 21.6 0.0 7.6 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 CDK98949.1 - 2.6e-30 102.6 0.6 0.00042 20.5 0.0 9.2 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_19 PF14559.6 CDK98949.1 - 5.5e-28 97.3 15.9 7e-08 32.9 0.1 5.9 3 1 3 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.6 CDK98949.1 - 7.5e-28 94.8 42.1 1.3e-05 25.6 0.3 10.3 3 1 8 11 11 10 9 Tetratricopeptide repeat TPR_11 PF13414.6 CDK98949.1 - 5.2e-24 83.6 2.0 7.5e-05 22.3 0.0 8.8 2 2 7 9 9 9 6 TPR repeat TPR_12 PF13424.6 CDK98949.1 - 6.2e-22 77.7 26.8 1.7e-10 41.0 1.8 6.5 3 2 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDK98949.1 - 5.8e-17 60.4 17.9 0.0009 19.1 0.0 8.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDK98949.1 - 7.6e-17 60.8 9.3 1.5 9.6 0.0 9.5 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDK98949.1 - 2.6e-16 58.9 34.7 0.00018 21.3 0.2 8.4 9 0 0 9 9 8 4 Tetratricopeptide repeat Methyltransf_23 PF13489.6 CDK98949.1 - 3.6e-14 52.9 0.0 8.3e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TPR_9 PF13371.6 CDK98949.1 - 1.1e-10 41.5 40.8 1.9e-05 24.7 3.7 8.0 4 2 5 9 9 8 3 Tetratricopeptide repeat Methyltransf_12 PF08242.12 CDK98949.1 - 2.9e-10 40.8 0.0 8.9e-10 39.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK98949.1 - 1.9e-09 38.1 0.3 1.6e-08 35.2 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK98949.1 - 3.2e-09 37.3 0.0 8.5e-09 36.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ANAPC3 PF12895.7 CDK98949.1 - 4.2e-09 36.5 1.1 0.0012 19.0 0.0 4.0 1 1 5 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 CDK98949.1 - 8.7e-09 35.0 7.0 0.064 12.4 0.0 4.4 1 1 1 4 4 4 3 Tetratricopeptide repeat Methyltransf_31 PF13847.6 CDK98949.1 - 1.3e-07 31.5 0.0 2.8e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 CDK98949.1 - 5.2e-07 29.5 0.0 9.7e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Nodulation protein S (NodS) TPR_MalT PF17874.1 CDK98949.1 - 1.5e-06 27.8 21.6 0.00011 21.7 3.4 3.1 2 1 1 3 3 3 2 MalT-like TPR region TPR_4 PF07721.14 CDK98949.1 - 3.9e-05 23.9 50.1 0.19 12.4 2.7 9.6 9 0 0 9 9 9 3 Tetratricopeptide repeat PknG_TPR PF16918.5 CDK98949.1 - 0.00016 20.5 5.6 0.0064 15.3 1.6 2.3 2 0 0 2 2 2 2 Protein kinase G tetratricopeptide repeat TPR_21 PF09976.9 CDK98949.1 - 0.00099 18.9 9.4 0.029 14.1 0.8 3.3 3 1 0 3 3 3 2 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 CDK98949.1 - 0.0011 19.2 8.4 0.78 10.1 0.6 5.4 2 2 1 4 4 4 1 Tetratricopeptide repeat ChAPs PF09295.10 CDK98949.1 - 0.0035 16.4 0.0 2.9 6.8 0.0 2.9 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) NARP1 PF12569.8 CDK98949.1 - 0.0036 16.3 0.1 1.4 7.8 0.0 2.9 2 2 2 4 4 4 1 NMDA receptor-regulated protein 1 FAT PF02259.23 CDK98949.1 - 0.0055 16.0 0.0 3.2 6.9 0.0 2.8 1 1 0 2 2 2 1 FAT domain HrpB1_HrpK PF09613.10 CDK98949.1 - 0.0081 15.8 1.9 4.9 6.8 0.2 3.5 1 1 2 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) BDV_P24 PF06595.11 CDK98949.1 - 0.035 14.0 0.0 0.059 13.2 0.0 1.2 1 0 0 1 1 1 0 Borna disease virus P24 protein Alkyl_sulf_dimr PF14863.6 CDK98949.1 - 0.074 13.5 1.6 12 6.4 0.0 3.6 4 0 0 4 4 3 0 Alkyl sulfatase dimerisation Ubie_methyltran PF01209.18 CDK98949.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Wzy_C_2 PF11846.8 CDK98949.1 - 0.18 11.7 7.3 3 7.7 0.3 4.1 1 1 4 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal PrmA PF06325.13 CDK98949.1 - 0.21 10.9 0.0 0.33 10.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) EAL PF00563.20 CDK98950.1 - 9.7e-48 162.8 0.1 1.8e-47 161.9 0.1 1.4 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK98950.1 - 4.7e-10 39.4 0.0 9.4e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain CBS PF00571.28 CDK98950.1 - 6.7e-08 32.9 0.1 1.8e-05 25.0 0.0 2.6 2 0 0 2 2 2 2 CBS domain SpoIIE PF07228.12 CDK98951.1 - 1.6e-36 126.0 1.3 2.9e-36 125.2 1.3 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) HATPase_c_2 PF13581.6 CDK98951.1 - 5.7e-22 78.0 0.0 1.9e-21 76.3 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain GAF_2 PF13185.6 CDK98951.1 - 4.3e-14 53.0 0.1 1.4e-13 51.3 0.0 1.9 2 0 0 2 2 2 1 GAF domain GAF PF01590.26 CDK98951.1 - 3.4e-11 43.9 0.0 8.7e-11 42.6 0.0 1.7 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 CDK98951.1 - 6.7e-08 32.9 0.0 1.8e-07 31.6 0.0 1.8 2 0 0 2 2 2 1 GAF domain STAS PF01740.21 CDK98952.1 - 1.6e-16 60.0 0.0 1.8e-16 59.8 0.0 1.0 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 CDK98952.1 - 9.6e-14 51.5 0.3 1.2e-13 51.2 0.3 1.1 1 0 0 1 1 1 1 STAS domain MlaE PF02405.16 CDK98953.1 - 3.7e-65 219.6 22.3 4.5e-65 219.3 22.3 1.1 1 0 0 1 1 1 1 Permease MlaE AphA_like PF14557.6 CDK98953.1 - 0.019 14.7 0.4 0.031 14.0 0.4 1.3 1 0 0 1 1 1 0 Putative AphA-like transcriptional regulator ABC_tran PF00005.27 CDK98954.1 - 2.8e-29 102.4 0.0 4e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98954.1 - 3e-05 24.0 1.2 0.042 13.6 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 CDK98954.1 - 4.9e-05 22.3 0.5 0.2 10.4 0.3 2.2 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 CDK98954.1 - 0.00016 21.3 0.1 0.00032 20.4 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SSE PF00437.20 CDK98954.1 - 0.0002 20.5 0.1 0.00033 19.8 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 CDK98954.1 - 0.00022 21.2 0.1 0.00037 20.5 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDK98954.1 - 0.00052 20.4 0.2 0.0022 18.4 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 CDK98954.1 - 0.0017 18.1 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDK98954.1 - 0.002 18.4 0.0 0.0032 17.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 CDK98954.1 - 0.0023 17.5 0.1 0.0049 16.5 0.1 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 CDK98954.1 - 0.0038 17.5 0.4 0.013 15.8 0.2 2.0 2 0 0 2 2 2 1 AAA domain MobB PF03205.14 CDK98954.1 - 0.0054 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.6 CDK98954.1 - 0.006 17.1 0.5 0.0098 16.4 0.1 1.5 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 CDK98954.1 - 0.0085 16.4 0.3 0.018 15.3 0.1 1.9 1 1 1 2 2 2 1 AAA domain NACHT PF05729.12 CDK98954.1 - 0.021 14.8 1.0 0.056 13.4 0.1 1.9 2 0 0 2 2 2 0 NACHT domain AAA_5 PF07728.14 CDK98954.1 - 0.021 14.8 0.5 1 9.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Pox_A32 PF04665.12 CDK98954.1 - 0.033 13.6 0.2 0.055 12.9 0.2 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein ATPase_2 PF01637.18 CDK98954.1 - 0.034 14.1 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 CDK98954.1 - 0.038 13.4 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PIF1 PF05970.14 CDK98954.1 - 0.061 12.5 0.0 0.089 11.9 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase AAA_24 PF13479.6 CDK98954.1 - 0.063 13.0 0.2 0.22 11.3 0.1 1.8 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CDK98954.1 - 0.078 12.2 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MMR_HSR1 PF01926.23 CDK98954.1 - 0.079 13.0 0.1 0.3 11.2 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 CDK98954.1 - 0.1 11.9 0.3 0.23 10.8 0.1 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 CDK98954.1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DAP3 PF10236.9 CDK98954.1 - 0.13 11.4 0.2 0.48 9.5 0.2 1.7 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 TrwB_AAD_bind PF10412.9 CDK98954.1 - 0.15 11.0 0.1 0.24 10.3 0.1 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Adeno_IVa2 PF02456.15 CDK98954.1 - 0.16 10.7 0.0 1.2 7.9 0.0 1.9 2 0 0 2 2 2 0 Adenovirus IVa2 protein SMC_N PF02463.19 CDK98954.1 - 0.2 11.1 0.3 2.5 7.5 0.3 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain CbiA PF01656.23 CDK98954.1 - 0.2 11.7 0.2 0.46 10.5 0.2 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain PduV-EutP PF10662.9 CDK98954.1 - 0.23 11.2 0.3 1.7 8.4 0.2 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MlaD PF02470.20 CDK98955.1 - 6.1e-11 42.5 0.0 1.5e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 MlaD protein SseC PF04888.12 CDK98955.1 - 0.00077 19.2 2.3 0.0013 18.4 2.3 1.3 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family DUF1664 PF07889.12 CDK98955.1 - 0.016 15.3 2.5 0.077 13.0 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ApoLp-III PF07464.11 CDK98955.1 - 0.055 13.6 1.2 0.78 9.8 0.1 2.1 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Laminin_II PF06009.12 CDK98955.1 - 0.087 12.8 3.1 2.4 8.2 0.1 2.4 1 1 1 2 2 2 0 Laminin Domain II Vps53_N PF04100.12 CDK98955.1 - 0.11 11.4 0.8 0.16 10.9 0.8 1.3 1 0 0 1 1 1 0 Vps53-like, N-terminal V-ATPase_C PF03223.15 CDK98955.1 - 0.13 11.7 1.2 0.23 10.8 1.2 1.3 1 1 0 1 1 1 0 V-ATPase subunit C DUF2205 PF10224.9 CDK98955.1 - 0.23 11.5 1.2 0.42 10.6 0.1 2.0 2 1 0 2 2 2 0 Short coiled-coil protein Alpha_GJ PF03229.13 CDK98955.1 - 0.29 11.7 4.2 0.87 10.1 0.2 2.5 2 0 0 2 2 2 0 Alphavirus glycoprotein J Baculo_PEP_C PF04513.12 CDK98955.1 - 0.51 10.4 13.0 23 5.0 13.0 2.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prominin PF05478.11 CDK98955.1 - 1.8 6.4 3.9 0.51 8.2 1.1 1.5 2 0 0 2 2 2 0 Prominin DUF948 PF06103.11 CDK98955.1 - 7.5 6.9 14.7 0.6 10.4 0.2 4.1 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) ABC_trans_aux PF03886.13 CDK98956.1 - 1.2e-18 67.3 0.1 1.6e-18 66.8 0.1 1.2 1 0 0 1 1 1 1 ABC-type transport auxiliary lipoprotein component tRNA_U5-meth_tr PF05958.11 CDK98957.1 - 6.4e-16 58.3 0.0 1.4e-14 53.9 0.0 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_25 PF13649.6 CDK98957.1 - 0.00039 21.1 0.0 0.00087 20.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDK98957.1 - 0.0019 17.7 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CDK98957.1 - 0.0042 16.8 0.0 0.0068 16.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 TehB PF03848.14 CDK98957.1 - 0.086 12.2 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Pmp3 PF01679.17 CDK98958.1 - 5.4e-07 29.7 8.9 6.1e-07 29.6 8.9 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Imm_superinfect PF14373.6 CDK98958.1 - 0.019 14.9 3.1 0.019 14.9 3.1 1.7 2 0 0 2 2 2 0 Superinfection immunity protein OAD_gamma PF04277.13 CDK98958.1 - 0.17 12.5 0.0 0.21 12.2 0.0 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Mur_ligase_M PF08245.12 CDK98959.1 - 9e-10 38.9 0.0 1.2e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CDK98959.1 - 1e-05 25.7 0.0 2.6e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain Carboxyl_trans PF01039.22 CDK98960.1 - 1.1e-17 63.9 0.0 1.3e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain zf-ACC PF17848.1 CDK98960.1 - 3.5e-12 46.2 2.0 6.3e-11 42.1 1.9 2.3 2 0 0 2 2 2 1 Acetyl-coA carboxylase zinc finger domain zf-ribbon_3 PF13248.6 CDK98960.1 - 0.015 14.7 1.0 1.7 8.2 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 CDK98960.1 - 0.027 14.4 1.5 0.065 13.2 1.5 1.6 1 1 1 2 2 2 0 Putative transposase DNA-binding domain DUF1451 PF07295.11 CDK98960.1 - 0.083 12.9 1.4 10 6.2 0.3 2.3 2 0 0 2 2 2 0 Zinc-ribbon containing domain TF_Zn_Ribbon PF08271.12 CDK98960.1 - 0.1 12.2 0.2 0.22 11.1 0.2 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Cys_rich_CPCC PF14206.6 CDK98960.1 - 0.11 12.3 0.2 0.19 11.6 0.2 1.3 1 0 0 1 1 1 0 Cysteine-rich CPCC Zn_Tnp_IS1595 PF12760.7 CDK98960.1 - 0.15 12.0 0.9 0.3 11.1 0.9 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DZR PF12773.7 CDK98960.1 - 0.18 11.9 0.7 0.58 10.2 0.7 1.6 1 1 0 1 1 1 0 Double zinc ribbon Nudix_N_2 PF14803.6 CDK98960.1 - 0.25 11.3 1.9 7.3 6.6 0.1 2.5 2 0 0 2 2 2 0 Nudix N-terminal Zn-ribbon_8 PF09723.10 CDK98960.1 - 0.5 10.5 2.4 1.2 9.3 2.4 1.7 1 1 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_2 PF13240.6 CDK98960.1 - 0.7 9.7 4.6 8.7 6.2 0.4 2.4 2 0 0 2 2 2 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.13 CDK98960.1 - 2 8.2 3.9 21 4.9 0.4 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit UPF0547 PF10571.9 CDK98960.1 - 2.5 8.2 5.9 21 5.3 0.5 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 PriA_CRR PF18319.1 CDK98960.1 - 3.5 7.7 7.9 11 6.1 7.0 2.3 2 1 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain Rubredoxin_2 PF18073.1 CDK98960.1 - 4.3 7.1 6.5 21 4.9 0.6 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain YhfH PF14149.6 CDK98960.1 - 4.3 7.4 5.1 19 5.4 0.4 2.3 1 1 1 2 2 2 0 YhfH-like protein Trp_syntA PF00290.20 CDK98961.1 - 1.2e-93 312.8 0.0 1.3e-93 312.6 0.0 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain His_biosynth PF00977.21 CDK98961.1 - 3.9e-05 23.2 0.1 9.6e-05 21.9 0.1 1.6 2 0 0 2 2 2 1 Histidine biosynthesis protein PcrB PF01884.17 CDK98961.1 - 0.00081 18.9 0.2 0.004 16.6 0.3 2.0 2 0 0 2 2 2 1 PcrB family PALP PF00291.25 CDK98962.1 - 7.8e-49 166.7 0.1 9e-49 166.5 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PSCyt1 PF07635.11 CDK98963.1 - 8.9e-10 39.0 0.1 1.3e-09 38.5 0.1 1.2 1 0 0 1 1 1 1 Planctomycete cytochrome C Cytochrome_CBB3 PF13442.6 CDK98963.1 - 0.0016 18.7 0.2 0.0035 17.6 0.2 1.6 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDK98963.1 - 0.015 16.4 0.0 0.022 15.9 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c Haem_bd PF14376.6 CDK98963.1 - 0.046 13.7 0.0 8.3 6.4 0.0 2.1 2 0 0 2 2 2 0 Haem-binding domain CTI PF06934.11 CDK98963.1 - 0.16 10.4 0.0 0.2 10.2 0.0 1.1 1 0 0 1 1 1 0 Fatty acid cis/trans isomerase (CTI) COX4_pro_2 PF07835.12 CDK98963.1 - 0.37 10.9 0.1 0.37 10.9 0.1 1.7 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV Response_reg PF00072.24 CDK98964.1 - 5.4e-49 165.0 0.8 7.8e-27 93.7 0.8 3.4 3 0 0 3 3 3 2 Response regulator receiver domain HATPase_c PF02518.26 CDK98964.1 - 6.7e-30 103.9 0.0 1.3e-29 103.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK98964.1 - 7.4e-19 67.5 0.6 6.7e-18 64.5 0.2 2.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.23 CDK98964.1 - 2.7e-12 46.8 0.8 2.7e-12 46.8 0.8 2.9 2 0 0 2 2 2 1 Hpt domain SLATT_4 PF18186.1 CDK98964.1 - 0.032 13.9 0.2 0.058 13.0 0.2 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 Cadherin_C_2 PF16492.5 CDK98964.1 - 0.1 13.3 0.1 0.2 12.4 0.1 1.4 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal BLOC1_2 PF10046.9 CDK98964.1 - 0.11 12.8 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HSCB_C PF07743.13 CDK98964.1 - 3.1 8.3 5.2 53 4.4 0.4 3.7 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain SBP_bac_11 PF13531.6 CDK98965.1 - 1.2e-43 149.5 0.0 1.4e-43 149.3 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CDK98965.1 - 0.00081 19.4 0.5 0.024 14.6 0.5 2.3 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein PBP_like PF12727.7 CDK98965.1 - 0.025 13.7 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 PBP superfamily domain Helicase_C_2 PF13307.6 CDK98966.1 - 5.1e-15 56.1 0.0 8.4e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD PF00270.29 CDK98966.1 - 0.0046 16.7 0.0 0.026 14.3 0.0 2.2 2 1 1 3 3 3 1 DEAD/DEAH box helicase RNase_II_C_S1 PF18614.1 CDK98966.1 - 0.11 12.5 0.8 6.3 6.8 0.0 3.0 2 0 0 2 2 2 0 RNase II-type exonuclease C-terminal S1 domain MFS_1 PF07690.16 CDK98967.1 - 8.8e-41 140.0 60.2 2.5e-39 135.2 54.5 2.9 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 CDK98967.1 - 0.00063 18.4 7.0 0.00063 18.4 7.0 4.3 2 2 2 4 4 4 3 MFS/sugar transport protein FdhD-NarQ PF02634.15 CDK98968.1 - 2.5e-62 210.6 0.1 2.9e-62 210.4 0.1 1.0 1 0 0 1 1 1 1 FdhD/NarQ family Molybdopterin PF00384.22 CDK98969.1 - 1.4e-71 241.7 0.0 1.8e-71 241.4 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 CDK98969.1 - 1.3e-24 86.4 0.2 2.7e-24 85.3 0.2 1.6 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Fer2_4 PF13510.6 CDK98969.1 - 2.2e-22 78.9 1.1 5.9e-22 77.5 1.1 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 CDK98969.1 - 4.8e-17 61.2 0.1 4.8e-17 61.2 0.1 2.6 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Molybdop_Fe4S4 PF04879.16 CDK98969.1 - 1.1e-14 54.2 1.6 2.6e-14 52.9 1.6 1.7 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Fe4S4 domain Fer4_21 PF14697.6 CDK98969.1 - 4.3e-06 26.7 7.0 4.3e-06 26.7 7.0 2.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDK98969.1 - 6.5e-06 26.7 9.4 6.5e-06 26.7 9.4 3.7 3 1 0 3 3 3 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDK98969.1 - 1.9e-05 24.7 10.5 1.9e-05 24.7 10.5 3.4 2 1 2 4 4 3 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK98969.1 - 2.7e-05 24.2 10.9 2.7e-05 24.2 10.9 3.1 3 1 1 4 4 4 2 4Fe-4S dicluster domain Fer4 PF00037.27 CDK98969.1 - 4.9e-05 23.0 12.1 8.7e-05 22.2 2.3 3.4 4 0 0 4 4 3 2 4Fe-4S binding domain Fer4_6 PF12837.7 CDK98969.1 - 0.00076 19.4 1.8 0.00076 19.4 1.8 4.1 5 0 0 5 5 3 2 4Fe-4S binding domain Fer4_2 PF12797.7 CDK98969.1 - 0.005 16.9 3.9 0.005 16.9 3.9 4.2 6 0 0 6 6 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 CDK98969.1 - 0.0077 16.7 9.4 0.0077 16.7 9.4 3.2 3 1 1 4 4 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDK98969.1 - 0.024 14.9 12.1 0.25 11.5 2.3 3.0 3 0 0 3 3 2 0 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDK98969.1 - 0.03 15.2 4.2 0.03 15.2 4.2 3.3 3 1 0 3 3 2 0 4Fe-4S double cluster binding domain Fer4_15 PF13459.6 CDK98969.1 - 0.24 12.2 8.6 6.5 7.6 0.5 2.9 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_13 PF13370.6 CDK98969.1 - 2.1 8.9 14.0 1.6 9.3 3.4 2.9 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 CDK98969.1 - 3.3 8.6 15.2 7.1 7.5 0.5 3.3 3 1 0 3 3 3 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDK98969.1 - 6.6 7.4 21.5 2.5 8.7 12.7 3.7 3 1 1 4 4 3 0 4Fe-4S dicluster domain Complex1_51K PF01512.17 CDK98970.1 - 1.8e-44 151.3 0.0 2.7e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 CDK98970.1 - 1.1e-29 102.3 0.3 2.2e-29 101.4 0.3 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 CDK98970.1 - 0.00027 20.8 0.3 0.00081 19.2 0.3 1.9 1 0 0 1 1 1 1 SLBB domain 2Fe-2S_thioredx PF01257.19 CDK98971.1 - 4.7e-40 136.8 0.0 5.2e-40 136.6 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin LysR_substrate PF03466.20 CDK98972.1 - 5.4e-30 104.3 0.8 8.9e-30 103.6 0.8 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDK98972.1 - 2.4e-16 59.4 0.1 5.3e-16 58.3 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family ThiW PF09512.10 CDK98972.1 - 0.053 13.6 0.3 0.089 12.9 0.3 1.3 1 0 0 1 1 1 0 Thiamine-precursor transporter protein (ThiW) SPOUT_MTase PF02590.17 CDK98974.1 - 2.9e-43 147.5 0.0 3.2e-43 147.3 0.0 1.0 1 0 0 1 1 1 1 Predicted SPOUT methyltransferase Thymosin PF01290.20 CDK98974.1 - 0.24 11.2 0.1 0.41 10.4 0.1 1.3 1 0 0 1 1 1 0 Thymosin beta-4 family RsfS PF02410.15 CDK98975.1 - 1.3e-28 99.4 0.0 1.4e-28 99.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation DUF3097 PF11296.8 CDK98975.1 - 0.089 12.0 0.1 0.1 11.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3097) CTP_transf_like PF01467.26 CDK98976.1 - 1.5e-17 64.1 0.0 2.1e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Aldedh PF00171.22 CDK98977.1 - 7.9e-15 54.3 11.7 1.3e-12 47.0 7.2 2.3 1 1 1 2 2 2 2 Aldehyde dehydrogenase family AA_kinase PF00696.28 CDK98978.1 - 8.7e-43 146.6 0.4 1.3e-42 146.1 0.4 1.3 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 CDK98978.1 - 4e-21 74.8 1.5 9.3e-21 73.6 0.2 2.3 2 0 0 2 2 2 1 PUA domain UPF0113 PF03657.13 CDK98978.1 - 0.049 13.9 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 UPF0113 PUA domain PUA_3 PF17785.1 CDK98978.1 - 0.061 13.1 0.0 0.17 11.7 0.0 1.8 1 0 0 1 1 1 0 PUA-like domain GTP1_OBG PF01018.22 CDK98979.1 - 7e-57 191.4 2.8 1.2e-56 190.6 2.8 1.4 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 CDK98979.1 - 3.2e-24 85.2 0.0 4.9e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDK98979.1 - 5.3e-12 45.5 0.0 3.2e-11 43.0 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 CDK98979.1 - 0.059 12.8 0.0 0.24 10.8 0.0 1.9 1 1 0 1 1 1 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDK98979.1 - 0.085 12.4 0.0 0.59 9.6 0.0 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SDA1 PF05285.12 CDK98979.1 - 1.2 8.5 10.0 1.5 8.2 10.0 1.1 1 0 0 1 1 1 0 SDA1 Ribosomal_L27 PF01016.19 CDK98980.1 - 3.4e-38 129.5 2.3 3.7e-38 129.4 2.3 1.0 1 0 0 1 1 1 1 Ribosomal L27 protein Ribosomal_L21p PF00829.21 CDK98981.1 - 2.2e-38 130.6 1.6 2.4e-38 130.4 1.6 1.0 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein GAF_2 PF13185.6 CDK98982.1 - 4.7e-05 23.7 0.1 6.4e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 CDK98982.1 - 0.0082 16.8 0.1 0.01 16.5 0.1 1.2 1 0 0 1 1 1 1 GAF domain AdoHcyase PF05221.17 CDK98983.1 - 3.6e-145 482.7 0.0 4e-145 482.6 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 CDK98983.1 - 2.6e-82 274.7 1.0 3.8e-82 274.1 1.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDK98983.1 - 3e-06 26.7 0.0 5.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 CDK98983.1 - 0.00028 20.5 0.1 0.00062 19.4 0.1 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 CDK98983.1 - 0.0095 15.8 0.2 0.019 14.9 0.2 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CDK98983.1 - 0.02 15.3 0.2 0.062 13.7 0.2 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.18 CDK98983.1 - 0.027 14.7 0.0 0.076 13.3 0.0 1.8 1 0 0 1 1 1 0 TrkA-N domain SpoVAE PF14097.6 CDK98983.1 - 0.066 12.9 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Stage V sporulation protein AE1 F420_oxidored PF03807.17 CDK98983.1 - 0.12 12.9 0.1 1.4 9.6 0.1 2.5 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent PEPCK_GTP PF00821.18 CDK98984.1 - 1.9e-167 556.6 0.2 2.6e-167 556.1 0.2 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 CDK98984.1 - 6e-107 356.2 0.0 7.9e-107 355.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain Pyrid_oxidase_2 PF13883.6 CDK98985.1 - 1.8e-12 47.6 0.0 2.6e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 CDK98985.1 - 5.5e-09 36.1 0.0 1.2e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF2470 PF10615.9 CDK98985.1 - 0.091 13.4 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2470) Archease PF01951.16 CDK98986.1 - 0.1 12.8 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Archease protein family (MTH1598/TM1083) ABC_tran PF00005.27 CDK98987.1 - 9.1e-32 110.4 0.0 1.2e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK98987.1 - 1.2e-09 38.5 1.0 2.6e-05 24.2 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDK98987.1 - 0.0002 21.8 0.7 0.00042 20.7 0.7 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 CDK98987.1 - 0.0034 17.0 1.0 0.012 15.2 1.0 2.0 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDK98987.1 - 0.0037 16.7 0.0 0.37 10.2 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDK98987.1 - 0.0051 17.3 0.0 0.008 16.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 CDK98987.1 - 0.0066 16.2 0.1 0.083 12.6 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CDK98987.1 - 0.011 15.4 0.6 0.32 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CDK98987.1 - 0.023 14.4 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP-synt_ab PF00006.25 CDK98987.1 - 0.041 13.5 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain NACHT PF05729.12 CDK98987.1 - 0.044 13.7 0.1 0.094 12.6 0.1 1.5 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 CDK98987.1 - 0.065 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 CDK98987.1 - 0.084 13.2 0.1 0.33 11.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CDK98987.1 - 0.093 12.6 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 NTPase AAA_28 PF13521.6 CDK98987.1 - 0.13 12.5 0.1 0.31 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 CDK98987.1 - 0.13 11.7 0.2 0.48 9.8 0.0 1.8 2 0 0 2 2 2 0 ADP-ribosylation factor family DLIC PF05783.11 CDK98987.1 - 0.14 11.0 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) cobW PF02492.19 CDK98987.1 - 0.2 11.2 0.1 0.3 10.7 0.1 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain CbiQ PF02361.16 CDK98988.1 - 4.5e-43 147.4 9.8 5.4e-43 147.2 9.8 1.1 1 0 0 1 1 1 1 Cobalt transport protein CbiN PF02553.15 CDK98989.1 - 1.2e-25 89.3 0.3 1.4e-25 89.1 0.3 1.1 1 0 0 1 1 1 1 Cobalt transport protein component CbiN CbiM PF01891.16 CDK98990.1 - 2e-45 155.2 22.1 2.3e-45 155.0 22.1 1.0 1 0 0 1 1 1 1 Cobalt uptake substrate-specific transmembrane region Response_reg PF00072.24 CDK98991.1 - 1.1e-28 99.6 0.2 1.7e-28 99.1 0.2 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK98991.1 - 5.4e-22 77.7 1.2 5.5e-22 77.6 0.0 1.7 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal HTH_11 PF08279.12 CDK98991.1 - 0.064 13.2 0.1 0.23 11.4 0.1 2.0 1 0 0 1 1 1 0 HTH domain Peptidase_S74 PF13884.6 CDK98991.1 - 0.11 12.9 0.1 0.2 12.0 0.1 1.5 1 0 0 1 1 1 0 Chaperone of endosialidase Stimulus_sens_1 PF13756.6 CDK98992.1 - 8e-29 100.5 0.0 2.6e-28 98.8 0.0 1.9 1 0 0 1 1 1 1 Stimulus-sensing domain HATPase_c PF02518.26 CDK98992.1 - 1.2e-24 87.0 0.0 2.6e-24 85.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sensor_TM1 PF13755.6 CDK98992.1 - 7.6e-16 57.6 0.2 7.6e-16 57.6 0.2 1.8 2 0 0 2 2 2 1 Sensor N-terminal transmembrane domain HisKA PF00512.25 CDK98992.1 - 8.7e-16 57.7 2.1 8.8e-16 57.7 0.3 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDK98992.1 - 3.3e-11 43.4 0.4 3.3e-11 43.4 0.4 2.8 3 0 0 3 3 3 1 HAMP domain HATPase_c_2 PF13581.6 CDK98992.1 - 0.0048 16.8 0.0 0.014 15.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 CDK98992.1 - 0.013 15.3 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Phage_integrase PF00589.22 CDK98993.1 - 1.7e-39 135.3 0.3 2.5e-39 134.8 0.3 1.2 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_4 PF13495.6 CDK98993.1 - 1.3e-15 57.6 0.0 3.8e-15 56.1 0.0 1.8 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 CDK98993.1 - 1.7e-10 41.0 0.3 8.6e-10 38.8 0.1 2.3 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_integr_3 PF16795.5 CDK98993.1 - 0.081 12.8 0.1 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 Archaeal phage integrase Y2_Tnp PF04986.13 CDK98994.1 - 1.2e-62 211.3 0.2 1.6e-62 210.9 0.2 1.2 1 0 0 1 1 1 1 Putative transposase Zn_Tnp_IS91 PF14319.6 CDK98994.1 - 1.9e-31 107.9 0.8 1.9e-31 107.9 0.8 2.1 2 0 0 2 2 2 1 Transposase zinc-binding domain zf-IS66 PF13005.7 CDK98994.1 - 0.083 13.3 9.2 1.9 9.0 0.6 4.3 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 Anti-TRAP PF15777.5 CDK98994.1 - 3.3 7.8 8.3 9.1 6.3 0.2 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Rep_1 PF01446.17 CDK98994.1 - 4.7 6.6 6.4 0.52 9.7 0.5 2.2 3 0 0 3 3 3 0 Replication protein OrfB_Zn_ribbon PF07282.11 CDK98994.1 - 5.8 6.9 8.4 37 4.4 0.1 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain HypA PF01155.19 CDK98994.1 - 9.4 6.3 6.4 5.6 7.0 2.1 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA HNH_2 PF13391.6 CDK98995.1 - 6e-05 23.1 0.1 0.00012 22.1 0.1 1.5 1 0 0 1 1 1 1 HNH endonuclease HNH PF01844.23 CDK98995.1 - 0.0002 21.5 3.2 0.0013 18.8 3.2 2.2 1 1 0 1 1 1 1 HNH endonuclease DUF2990 PF11693.8 CDK98997.1 - 0.12 12.6 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2990) Glyco_hydro_67M PF07488.12 CDK98997.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 middle domain NTP_transf_2 PF01909.23 CDK98998.1 - 0.016 15.5 0.0 0.017 15.4 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyltransferase domain Hpr_kinase_C PF07475.12 CDK98999.1 - 4e-19 68.8 0.1 7.3e-19 67.9 0.1 1.4 1 1 0 1 1 1 1 HPr Serine kinase C-terminal domain Mg_chelatase PF01078.21 CDK98999.1 - 0.016 14.6 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATP_bind_2 PF03668.15 CDK99000.1 - 4.9e-84 282.0 0.0 5.8e-84 281.7 0.0 1.0 1 0 0 1 1 1 1 P-loop ATPase protein family AAA_33 PF13671.6 CDK99000.1 - 9.7e-05 22.6 0.8 2.6 8.2 0.0 3.2 2 1 1 3 3 3 2 AAA domain AAA_18 PF13238.6 CDK99000.1 - 0.00016 22.2 1.5 0.068 13.7 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CDK99000.1 - 0.0067 16.2 0.1 0.013 15.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CDK99000.1 - 0.027 15.0 0.0 0.057 13.9 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 CDK99000.1 - 0.042 14.2 0.4 0.074 13.4 0.4 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 CDK99000.1 - 0.081 13.3 1.3 11 6.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDK99000.1 - 0.16 11.2 0.0 0.92 8.7 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin EIIA-man PF03610.16 CDK99001.1 - 1.3e-29 102.8 0.2 1.5e-29 102.6 0.2 1.1 1 0 0 1 1 1 1 PTS system fructose IIA component Tubulin PF00091.25 CDK99001.1 - 0.013 15.7 0.0 0.015 15.5 0.0 1.1 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain PTS-HPr PF00381.19 CDK99002.1 - 1.7e-26 92.2 0.4 2e-26 92.0 0.4 1.0 1 0 0 1 1 1 1 PTS HPr component phosphorylation site PEP-utilizers_C PF02896.18 CDK99003.1 - 3.9e-99 331.5 0.0 6.5e-99 330.7 0.0 1.3 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PEP-utilisers_N PF05524.13 CDK99003.1 - 1.6e-25 89.6 3.5 2.4e-24 85.7 3.5 2.3 2 0 0 2 2 2 1 PEP-utilising enzyme, N-terminal PEP-utilizers PF00391.23 CDK99003.1 - 2.8e-21 75.0 0.8 6.6e-21 73.8 0.8 1.7 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain Na_H_Exchanger PF00999.21 CDK99004.1 - 2e-41 142.1 48.9 2.4e-41 141.8 48.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family CorC_HlyC PF03471.17 CDK99004.1 - 0.00077 19.4 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 Transporter associated domain Na_H_Exchanger PF00999.21 CDK99005.1 - 4.2e-63 213.4 54.1 5.6e-63 213.0 54.1 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.18 CDK99005.1 - 1.9e-19 70.0 0.0 3.8e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Response_reg PF00072.24 CDK99006.1 - 2.5e-09 37.3 0.0 2.9e-09 37.1 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain NadA PF02445.16 CDK99007.1 - 1.9e-115 385.1 0.0 2.2e-115 384.9 0.0 1.0 1 0 0 1 1 1 1 Quinolinate synthetase A protein QRPTase_C PF01729.19 CDK99008.1 - 2.5e-56 190.1 0.1 3.9e-56 189.5 0.1 1.3 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 CDK99008.1 - 1.1e-27 95.9 0.6 2.1e-27 95.0 0.1 1.7 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain TMP-TENI PF02581.17 CDK99008.1 - 0.0031 16.9 0.6 0.023 14.0 0.6 2.1 1 1 0 1 1 1 1 Thiamine monophosphate synthase Biotin_lipoyl_2 PF13533.6 CDK99008.1 - 0.019 14.8 0.0 0.053 13.4 0.0 1.7 1 0 0 1 1 1 0 Biotin-lipoyl like Ribul_P_3_epim PF00834.19 CDK99008.1 - 0.027 13.8 0.5 0.08 12.3 0.1 1.8 1 1 0 2 2 2 0 Ribulose-phosphate 3 epimerase family PHB_acc_N PF07879.11 CDK99008.1 - 0.16 12.1 0.1 12 6.1 0.0 2.4 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain Tenui_PVC2 PF06656.11 CDK99008.1 - 0.21 9.4 0.0 0.29 9.0 0.0 1.1 1 0 0 1 1 1 0 Tenuivirus PVC2 protein FAD_binding_2 PF00890.24 CDK99009.1 - 2.5e-104 349.7 2.7 2.6e-104 349.6 2.1 1.3 2 0 0 2 2 2 1 FAD binding domain Succ_DH_flav_C PF02910.20 CDK99009.1 - 6.8e-14 51.9 0.0 1.4e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term DAO PF01266.24 CDK99009.1 - 4.3e-09 36.4 4.0 3.3e-07 30.2 4.0 2.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDK99009.1 - 9e-08 31.7 0.1 0.0013 18.1 0.1 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDK99009.1 - 0.0001 21.5 0.1 0.00024 20.3 0.1 1.6 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 CDK99009.1 - 0.00011 21.1 1.4 0.67 8.6 0.3 3.2 3 0 0 3 3 3 2 HI0933-like protein Thi4 PF01946.17 CDK99009.1 - 0.017 14.3 1.7 0.11 11.8 0.3 2.7 2 1 1 3 3 3 0 Thi4 family NAD_binding_9 PF13454.6 CDK99009.1 - 0.044 13.8 0.4 0.38 10.7 0.4 2.2 1 1 0 1 1 1 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 CDK99009.1 - 0.25 10.4 0.1 1.9 7.5 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) cNMP_binding PF00027.29 CDK99010.1 - 1.3e-20 73.2 0.2 2.2e-20 72.5 0.1 1.4 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain GGDEF PF00990.21 CDK99013.1 - 1.2e-42 145.4 0.0 2e-42 144.7 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain CZB PF13682.6 CDK99013.1 - 1.6e-08 34.9 0.2 3.1e-08 33.9 0.2 1.4 1 0 0 1 1 1 1 Chemoreceptor zinc-binding domain GGDEF_2 PF17853.1 CDK99013.1 - 0.068 13.4 0.3 0.33 11.2 0.1 2.0 2 0 0 2 2 2 0 GGDEF-like domain Sel1 PF08238.12 CDK99014.1 - 6.8e-46 153.7 49.2 2.2e-08 34.5 1.3 9.3 9 1 0 9 9 9 8 Sel1 repeat PPR_long PF17177.4 CDK99014.1 - 0.13 11.7 0.1 11 5.4 0.0 2.3 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP Bac_DNA_binding PF00216.21 CDK99016.1 - 6.8e-34 116.0 0.0 7.4e-34 115.8 0.0 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 CDK99016.1 - 9.1e-07 29.0 0.0 9.9e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif DUF2267 PF10025.9 CDK99016.1 - 0.011 16.0 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) HU-CCDC81_euk_2 PF18289.1 CDK99016.1 - 0.06 13.5 0.0 0.084 13.0 0.0 1.2 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 LuxE PF04443.12 CDK99017.1 - 9.4e-42 143.4 0.0 1.1e-41 143.1 0.0 1.0 1 0 0 1 1 1 1 Acyl-protein synthetase, LuxE LuxC PF05893.14 CDK99018.1 - 3.6e-35 121.8 0.0 2.2e-34 119.2 0.0 1.8 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1127 PF06568.11 CDK99018.1 - 0.97 9.2 6.0 1.6 8.5 0.4 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1127) ABC_tran PF00005.27 CDK99019.1 - 1e-47 162.1 0.0 2.4e-23 83.1 0.0 2.8 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CDK99019.1 - 5.6e-27 93.6 9.8 1.7e-26 92.0 3.2 2.7 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 CDK99019.1 - 1.5e-13 51.3 0.9 0.0067 16.3 0.0 4.3 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK99019.1 - 2.6e-08 33.6 0.5 0.0053 16.2 0.0 4.0 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDK99019.1 - 6e-06 25.9 0.0 0.07 12.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CDK99019.1 - 2e-05 25.2 4.5 0.016 15.7 0.1 3.1 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 CDK99019.1 - 3e-05 23.8 1.7 0.22 11.2 0.2 2.8 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CDK99019.1 - 3.5e-05 23.8 0.2 0.22 11.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CDK99019.1 - 7.2e-05 22.8 0.1 0.03 14.4 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.29 CDK99019.1 - 0.00017 22.0 1.4 0.093 13.2 0.0 3.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 CDK99019.1 - 0.00026 20.7 0.4 0.047 13.3 0.0 2.8 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 CDK99019.1 - 0.00034 21.1 0.3 0.59 10.5 0.0 2.7 3 0 0 3 3 2 2 AAA ATPase domain AAA_24 PF13479.6 CDK99019.1 - 0.00097 18.9 0.1 0.75 9.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_13 PF13166.6 CDK99019.1 - 0.00098 17.9 0.6 0.43 9.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 CDK99019.1 - 0.00098 19.4 0.6 1.8 8.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 CDK99019.1 - 0.0019 18.5 0.2 1.5 9.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain Roc PF08477.13 CDK99019.1 - 0.0021 18.3 0.1 0.59 10.4 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.25 CDK99019.1 - 0.0023 17.6 0.0 0.99 9.0 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.6 CDK99019.1 - 0.0026 18.3 0.4 2.5 8.6 0.0 2.9 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 CDK99019.1 - 0.0037 17.2 0.1 3 7.7 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_27 PF13514.6 CDK99019.1 - 0.0051 16.4 0.1 1.5 8.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_8 PF12780.7 CDK99019.1 - 0.0088 15.4 0.1 4.2 6.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 DUF4440 PF14534.6 CDK99019.1 - 0.013 15.9 0.8 1.9 9.0 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4440) TsaE PF02367.17 CDK99019.1 - 0.013 15.5 0.1 0.36 10.8 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CDK99019.1 - 0.015 15.4 5.1 1.3 9.1 0.0 3.2 4 0 0 4 4 2 0 AAA domain Arf PF00025.21 CDK99019.1 - 0.018 14.5 0.0 7 6.1 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family IstB_IS21 PF01695.17 CDK99019.1 - 0.019 14.7 0.1 3.3 7.4 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein SbcCD_C PF13558.6 CDK99019.1 - 0.021 15.0 0.4 2.8 8.2 0.0 3.7 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 CDK99019.1 - 0.031 13.9 0.3 4.4 6.9 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ABC_tran_CTD PF16326.5 CDK99019.1 - 0.046 14.0 3.4 0.069 13.4 0.2 2.6 2 0 0 2 2 2 0 ABC transporter C-terminal domain NB-ARC PF00931.22 CDK99019.1 - 0.05 12.8 0.1 0.94 8.6 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_14 PF13173.6 CDK99019.1 - 0.066 13.3 0.1 8.3 6.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CDK99019.1 - 0.066 13.0 0.1 0.93 9.2 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.12 CDK99019.1 - 0.077 12.3 5.2 1.6 7.9 0.1 2.7 3 0 0 3 3 3 0 Zeta toxin SRPRB PF09439.10 CDK99019.1 - 0.081 12.4 0.0 0.3 10.5 0.0 1.9 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MeaB PF03308.16 CDK99019.1 - 0.086 11.8 0.1 6.5 5.7 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 CDK99019.1 - 0.098 12.3 3.1 9.9 5.8 0.1 3.3 4 0 0 4 4 3 0 AAA ATPase domain NTPase_1 PF03266.15 CDK99019.1 - 0.1 12.5 0.3 6.4 6.6 0.0 2.5 2 0 0 2 2 2 0 NTPase AAA_7 PF12775.7 CDK99019.1 - 0.1 12.1 0.1 3.4 7.1 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 CDK99019.1 - 0.12 11.9 0.1 2.9 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 CDK99019.1 - 0.15 11.8 0.0 0.82 9.4 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Ploopntkinase1 PF18748.1 CDK99019.1 - 0.16 11.4 0.0 4.1 6.9 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase1 DUF3584 PF12128.8 CDK99019.1 - 0.2 9.2 9.6 0.79 7.2 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) DLIC PF05783.11 CDK99019.1 - 0.55 9.0 4.3 2.8 6.7 0.0 2.5 3 0 0 3 3 3 0 Dynein light intermediate chain (DLIC) peroxidase PF00141.23 CDK99020.1 - 1.8e-90 302.7 0.0 1.9e-49 168.5 0.0 2.3 2 0 0 2 2 2 2 Peroxidase ORF6N PF10543.9 CDK99020.1 - 0.02 15.1 0.0 0.083 13.1 0.0 2.0 2 0 0 2 2 2 0 ORF6N domain Rop-like PF05082.13 CDK99021.1 - 6.3e-29 99.6 2.2 7.4e-29 99.4 2.2 1.0 1 0 0 1 1 1 1 Rop-like GAS PF13851.6 CDK99021.1 - 0.00014 21.3 0.2 0.00015 21.2 0.2 1.0 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DPM3 PF08285.11 CDK99021.1 - 0.0072 16.5 0.5 1.5 9.1 0.0 2.1 2 0 0 2 2 2 2 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LPP PF04728.13 CDK99021.1 - 0.013 15.9 0.7 0.2 12.1 0.5 2.0 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Spc7 PF08317.11 CDK99021.1 - 0.013 14.4 0.2 0.013 14.4 0.2 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein BRE1 PF08647.11 CDK99021.1 - 0.022 14.8 0.9 0.25 11.4 0.3 2.0 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase CENP-F_leu_zip PF10473.9 CDK99021.1 - 0.093 12.8 1.1 0.25 11.4 1.1 1.7 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fzo_mitofusin PF04799.13 CDK99021.1 - 0.096 12.2 0.2 0.11 12.0 0.2 1.0 1 0 0 1 1 1 0 fzo-like conserved region Seryl_tRNA_N PF02403.22 CDK99021.1 - 0.099 12.9 1.4 0.31 11.3 0.3 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain PRP1_N PF06424.12 CDK99021.1 - 0.15 12.5 0.2 0.19 12.1 0.1 1.3 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal BST2 PF16716.5 CDK99021.1 - 0.43 11.2 4.1 6.8 7.4 0.5 2.0 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Mem_trans PF03547.18 CDK99023.1 - 1.2e-30 106.2 21.7 4.8e-18 64.7 7.8 2.0 2 0 0 2 2 2 2 Membrane transport protein FAD-oxidase_C PF02913.19 CDK99024.1 - 2.1e-55 188.0 2.9 9.2e-55 186.0 1.3 2.3 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CDK99024.1 - 7.6e-32 110.0 1.5 1.5e-31 109.0 1.5 1.6 1 0 0 1 1 1 1 FAD binding domain Fer4_7 PF12838.7 CDK99024.1 - 3.4e-11 43.6 5.0 7.6e-11 42.4 5.0 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDK99024.1 - 4.4e-11 43.1 3.0 9.7e-11 42.0 3.0 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDK99024.1 - 1.1e-09 38.7 3.2 2.1e-09 37.8 3.2 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 CDK99024.1 - 3.7e-07 29.7 12.3 0.0025 17.6 3.5 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 CDK99024.1 - 1.3e-06 28.5 4.8 3.4e-06 27.1 4.8 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK99024.1 - 1.3e-06 28.4 8.0 0.0001 22.3 10.0 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain CCG PF02754.16 CDK99024.1 - 6.9e-06 26.2 8.3 0.01 16.0 0.0 3.8 4 0 0 4 4 4 2 Cysteine-rich domain Fer4_16 PF13484.6 CDK99024.1 - 1.1e-05 26.3 3.8 3.3e-05 24.7 3.8 1.9 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_2 PF12797.7 CDK99024.1 - 6.2e-05 22.9 12.6 0.0095 16.0 2.8 2.8 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CDK99024.1 - 0.00022 21.5 9.5 0.055 14.0 1.4 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 CDK99024.1 - 0.0012 18.9 12.9 0.16 12.1 3.9 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 CDK99024.1 - 0.0032 17.6 11.8 0.087 13.0 11.8 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDK99024.1 - 0.014 15.6 1.8 1.8 8.8 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_22 PF17179.4 CDK99024.1 - 0.11 13.3 5.7 2.5 9.0 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 CDK99024.1 - 1 10.0 15.4 2.7 8.6 2.7 3.0 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 CDK99024.1 - 3.6 8.8 18.2 11 7.2 4.1 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain LUD_dom PF02589.15 CDK99025.1 - 1.1e-27 97.0 0.0 2.2e-26 92.8 0.0 2.0 1 1 0 1 1 1 1 LUD domain LUD_dom PF02589.15 CDK99026.1 - 1.1e-54 185.1 0.1 1.5e-54 184.6 0.1 1.2 1 0 0 1 1 1 1 LUD domain DUF3390 PF11870.8 CDK99026.1 - 5.7e-24 84.3 0.6 9.9e-24 83.5 0.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3390) Fer4_8 PF13183.6 CDK99026.1 - 5e-09 36.5 4.7 1.3e-08 35.2 4.7 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 CDK99026.1 - 1.9e-08 33.8 11.5 1.3e-05 24.8 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 CDK99026.1 - 2.1e-07 31.0 7.5 2e-05 24.6 8.9 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK99026.1 - 5.9e-06 26.1 10.8 0.0046 17.0 3.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 CDK99026.1 - 8.5e-06 26.3 9.0 2.4e-05 24.8 9.0 1.8 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDK99026.1 - 0.00019 21.5 9.1 0.012 15.8 11.0 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDK99026.1 - 0.00034 20.5 13.0 0.0011 19.0 1.9 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.6 CDK99026.1 - 0.0008 19.6 2.7 0.24 11.6 0.3 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDK99026.1 - 0.0012 19.3 7.0 0.0058 17.1 7.0 2.1 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDK99026.1 - 0.0018 19.1 10.0 0.0098 16.8 10.1 2.1 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_3 PF12798.7 CDK99026.1 - 0.0019 19.0 15.7 0.055 14.4 2.1 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 CDK99026.1 - 0.0028 17.7 7.7 0.47 10.6 0.8 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 CDK99026.1 - 0.0066 16.9 11.4 0.014 15.9 2.1 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_20 PF14691.6 CDK99026.1 - 0.026 14.3 3.6 1 9.1 0.3 2.4 2 0 0 2 2 2 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_13 PF13370.6 CDK99026.1 - 1.8 9.1 8.9 30 5.2 8.9 2.5 1 1 0 1 1 1 0 4Fe-4S single cluster domain of Ferredoxin I CCG PF02754.16 CDK99027.1 - 1.1e-29 102.4 0.1 1.7e-14 53.8 0.1 2.1 2 0 0 2 2 2 2 Cysteine-rich domain TPR_14 PF13428.6 CDK99027.1 - 0.083 13.8 0.4 0.37 11.7 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat UPF0160 PF03690.13 CDK99028.1 - 9e-79 265.4 0.0 1e-78 265.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) SSF PF00474.17 CDK99029.1 - 1.1e-106 357.2 36.2 1.6e-106 356.6 36.2 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family DUF2818 PF10993.8 CDK99029.1 - 0.026 15.1 2.6 0.07 13.7 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2818) DUF485 PF04341.12 CDK99030.1 - 6.7e-29 99.7 0.2 7.6e-29 99.5 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF485 Yip1 PF04893.17 CDK99030.1 - 9.2e-05 22.2 1.3 0.00011 22.0 1.3 1.0 1 0 0 1 1 1 1 Yip1 domain Phage_holin_3_6 PF07332.11 CDK99030.1 - 0.32 11.1 3.9 0.38 10.8 3.9 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3095 PF11294.8 CDK99031.1 - 1.6e-89 300.7 0.0 1.8e-89 300.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3095) Redoxin PF08534.10 CDK99032.1 - 6.8e-28 97.2 0.0 8.3e-28 97.0 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CDK99032.1 - 1.7e-17 63.5 0.0 2e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family PGM_PMM_I PF02878.16 CDK99032.1 - 0.16 11.7 0.3 0.63 9.8 0.1 1.8 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I TonB_dep_Rec PF00593.24 CDK99033.1 - 8.7e-31 108.3 13.7 1.2e-30 107.9 13.7 1.1 1 0 0 1 1 1 1 TonB dependent receptor Plug PF07715.15 CDK99033.1 - 4e-10 40.2 0.2 3.2e-09 37.3 0.1 2.3 2 0 0 2 2 2 1 TonB-dependent Receptor Plug Domain DUF2946 PF11162.8 CDK99034.1 - 0.065 13.9 9.7 0.077 13.7 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) Peripla_BP_6 PF13458.6 CDK99035.1 - 6.2e-74 249.7 6.7 7.6e-74 249.4 6.7 1.0 1 0 0 1 1 1 1 Periplasmic binding protein Peripla_BP_5 PF13433.6 CDK99035.1 - 2.3e-24 86.1 0.0 2.9e-24 85.8 0.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain ANF_receptor PF01094.28 CDK99035.1 - 2.5e-15 56.5 0.0 3.2e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region BPD_transp_2 PF02653.16 CDK99036.1 - 1.2e-37 129.5 40.2 1.5e-37 129.2 40.2 1.1 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component DUF575 PF04746.12 CDK99036.1 - 0.071 13.4 0.5 0.18 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF575) BPD_transp_2 PF02653.16 CDK99037.1 - 5.3e-39 134.0 31.5 5.3e-39 134.0 31.5 1.3 1 1 0 1 1 1 1 Branched-chain amino acid transport system / permease component ABC_tran PF00005.27 CDK99038.1 - 4.2e-26 92.1 0.0 5.5e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter BCA_ABC_TP_C PF12399.8 CDK99038.1 - 1.3e-09 37.7 0.2 2.8e-09 36.7 0.2 1.6 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_21 PF13304.6 CDK99038.1 - 1.1e-06 28.7 0.5 0.00071 19.5 0.1 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDK99038.1 - 0.00016 21.3 0.1 0.00032 20.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDK99038.1 - 0.00049 20.1 0.1 0.00084 19.3 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_27 PF13514.6 CDK99038.1 - 0.0013 18.4 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDK99038.1 - 0.0072 16.1 0.5 0.013 15.2 0.5 1.7 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDK99038.1 - 0.0094 15.4 0.0 0.15 11.4 0.0 2.0 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDK99038.1 - 0.015 15.7 1.3 0.033 14.6 1.3 1.7 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 CDK99038.1 - 0.015 15.4 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.6 CDK99038.1 - 0.027 14.1 0.4 0.095 12.3 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CDK99038.1 - 0.03 14.8 0.0 0.045 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDK99038.1 - 0.064 12.5 0.0 0.09 12.0 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin DUF2813 PF11398.8 CDK99038.1 - 0.067 12.4 0.0 0.094 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) AAA_33 PF13671.6 CDK99038.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain SelB-wing_1 PF09105.10 CDK99038.1 - 0.22 11.5 2.1 2.2 8.3 0.9 2.4 1 1 1 2 2 2 0 Elongation factor SelB, winged helix AAA_15 PF13175.6 CDK99038.1 - 0.33 10.6 0.0 0.61 9.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 CDK99039.1 - 3.5e-30 105.3 0.0 5.1e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter MukB PF04310.12 CDK99039.1 - 0.00096 19.0 0.1 0.005 16.7 0.0 1.8 2 0 0 2 2 2 1 MukB N-terminal AAA_29 PF13555.6 CDK99039.1 - 0.0069 16.1 0.1 0.016 15.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CDK99039.1 - 0.017 14.6 0.0 1.1 8.6 0.1 2.1 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDK99039.1 - 0.023 14.5 0.0 4.9 6.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDK99039.1 - 0.037 14.4 0.2 0.058 13.8 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 CDK99039.1 - 0.051 13.3 0.1 0.1 12.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 CDK99039.1 - 0.11 12.1 0.4 0.24 11.0 0.4 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain SbcCD_C PF13558.6 CDK99039.1 - 0.14 12.4 0.1 4.2 7.7 0.1 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 CDK99039.1 - 0.21 12.1 0.1 0.27 11.7 0.1 1.1 1 0 0 1 1 1 0 AAA domain PhnA PF03831.14 CDK99040.1 - 1.2e-31 108.4 7.4 1.5e-31 108.1 7.4 1.1 1 0 0 1 1 1 1 PhnA domain PhnA_Zn_Ribbon PF08274.12 CDK99040.1 - 3.1e-14 52.6 5.1 5.2e-14 51.9 5.1 1.3 1 0 0 1 1 1 1 PhnA Zinc-Ribbon A2L_zn_ribbon PF08792.10 CDK99040.1 - 0.00012 21.7 0.7 0.00022 20.9 0.7 1.4 1 0 0 1 1 1 1 A2L zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 CDK99040.1 - 0.00037 20.4 1.3 0.00064 19.7 1.3 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 CDK99040.1 - 0.0022 17.9 0.9 0.0022 17.9 0.9 1.7 2 0 0 2 2 2 1 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 CDK99040.1 - 0.0027 17.2 1.6 0.0027 17.2 1.6 1.9 2 1 0 2 2 2 1 TFIIB zinc-binding Ribosomal_L37ae PF01780.19 CDK99040.1 - 0.0056 16.7 0.4 0.0077 16.3 0.4 1.2 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RRN7 PF11781.8 CDK99040.1 - 0.0092 15.6 0.7 0.028 14.1 0.2 2.1 2 0 0 2 2 2 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zinc_ribbon_2 PF13240.6 CDK99040.1 - 0.012 15.4 1.9 0.012 15.4 1.9 2.0 2 1 0 2 2 1 0 zinc-ribbon domain DUF4469 PF14734.6 CDK99040.1 - 0.037 14.2 0.4 0.044 13.9 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4469) with IG-like fold PADR1 PF08063.12 CDK99040.1 - 0.063 13.1 0.9 0.13 12.1 0.9 1.4 1 0 0 1 1 1 0 PADR1 (NUC008) domain TFIIS_C PF01096.18 CDK99040.1 - 0.089 12.7 5.0 1.2 9.0 0.4 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-C4_Topoisom PF01396.19 CDK99040.1 - 0.093 12.5 3.2 0.53 10.1 0.2 2.5 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-NADH-PPase PF09297.11 CDK99040.1 - 0.1 12.3 3.0 1.5 8.5 0.2 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Zn-ribbon_8 PF09723.10 CDK99040.1 - 0.13 12.4 4.2 0.98 9.6 4.3 2.1 1 1 0 1 1 1 0 Zinc ribbon domain HypA PF01155.19 CDK99040.1 - 0.14 12.2 1.0 0.29 11.2 1.0 1.6 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.14 CDK99040.1 - 0.42 10.6 3.1 1.8 8.6 0.2 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid UPF0547 PF10571.9 CDK99040.1 - 0.44 10.7 5.8 1.9 8.7 0.8 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-TFIIB PF13453.6 CDK99040.1 - 0.69 9.3 4.3 7.9 5.9 4.8 2.1 1 1 1 2 2 2 0 Transcription factor zinc-finger zf-ribbon_3 PF13248.6 CDK99040.1 - 0.81 9.2 8.9 8.1 6.0 6.3 3.1 2 1 1 3 3 3 0 zinc-ribbon domain DUF4379 PF14311.6 CDK99040.1 - 0.84 10.1 8.9 0.69 10.3 2.5 2.3 1 1 1 2 2 2 0 Probable Zinc-ribbon domain Zn_ribbon_SprT PF17283.2 CDK99040.1 - 1.1 9.2 3.7 28 4.7 0.1 2.7 3 0 0 3 3 3 0 SprT-like zinc ribbon domain zf-ISL3 PF14690.6 CDK99040.1 - 1.1 9.9 7.1 1.3 9.7 0.5 2.7 2 1 1 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn_Tnp_IS1 PF03811.13 CDK99040.1 - 1.6 8.5 4.5 0.76 9.6 0.3 2.3 1 1 1 2 2 2 0 InsA N-terminal domain DNA_ligase_ZBD PF03119.16 CDK99040.1 - 2.2 8.4 6.5 1.9 8.6 0.2 2.6 2 1 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Rubredoxin PF00301.20 CDK99040.1 - 4.3 7.4 7.5 13 5.9 1.7 2.4 1 1 1 2 2 2 0 Rubredoxin zf-ACC PF17848.1 CDK99040.1 - 5.6 7.1 9.8 1.2e+02 2.8 9.0 2.6 2 1 0 2 2 1 0 Acetyl-coA carboxylase zinc finger domain Response_reg PF00072.24 CDK99041.1 - 1.1e-25 89.9 0.1 2.8e-25 88.7 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK99041.1 - 5.7e-23 80.8 0.0 4.8e-22 77.8 0.0 2.1 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal FleQ PF06490.11 CDK99041.1 - 0.063 13.7 0.0 0.54 10.6 0.0 2.1 2 0 0 2 2 2 0 Flagellar regulatory protein FleQ KdpD PF02702.17 CDK99042.1 - 5.3e-97 323.4 0.0 8.1e-97 322.8 0.0 1.3 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain DUF4118 PF13493.6 CDK99042.1 - 6.4e-31 106.3 10.4 1.2e-30 105.4 10.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4118) HATPase_c PF02518.26 CDK99042.1 - 6.5e-25 87.8 0.0 1.3e-24 86.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK99042.1 - 6.3e-13 48.6 0.6 6.3e-13 48.6 0.6 3.3 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain GAF_3 PF13492.6 CDK99042.1 - 1.4e-11 44.8 0.0 3.2e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 GAF domain Usp PF00582.26 CDK99042.1 - 2.1e-09 38.0 3.7 5.7e-09 36.6 1.6 2.8 2 1 0 2 2 2 1 Universal stress protein family GAF_2 PF13185.6 CDK99042.1 - 2e-06 28.2 1.2 5.2e-06 26.8 0.1 2.5 3 0 0 3 3 3 1 GAF domain HATPase_c_2 PF13581.6 CDK99042.1 - 0.00019 21.4 0.0 0.00065 19.7 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain AP_endonuc_2 PF01261.24 CDK99042.1 - 0.068 12.6 1.0 0.15 11.5 0.1 2.0 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel DUF2779 PF11074.8 CDK99042.1 - 0.14 12.6 0.0 0.28 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function(DUF2779) DUF4126 PF13548.6 CDK99042.1 - 0.49 10.1 7.9 1.2 8.8 7.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4126) KdpC PF02669.15 CDK99043.1 - 8.3e-73 244.1 0.1 9.3e-73 243.9 0.1 1.0 1 0 0 1 1 1 1 K+-transporting ATPase, c chain Hydrolase PF00702.26 CDK99044.1 - 1.7e-33 116.7 1.3 2.8e-33 116.0 1.3 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CDK99044.1 - 2.2e-31 108.8 2.2 2.2e-31 108.8 2.2 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CDK99044.1 - 6.5e-05 22.8 0.3 0.0019 18.0 0.2 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDK99044.1 - 0.0003 21.3 0.1 0.0015 19.0 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase CBS PF00571.28 CDK99044.1 - 0.074 13.5 0.0 0.26 11.8 0.0 2.0 1 0 0 1 1 1 0 CBS domain KdpA PF03814.15 CDK99045.1 - 3.9e-238 791.1 39.4 4.7e-238 790.8 39.4 1.0 1 0 0 1 1 1 1 Potassium-transporting ATPase A subunit CcmE PF03100.15 CDK99045.1 - 0.21 11.6 2.1 8.9 6.3 0.1 3.5 3 1 0 3 3 3 0 CcmE Potass_KdpF PF09604.10 CDK99046.1 - 1.9e-09 37.3 5.3 2.1e-09 37.1 5.3 1.0 1 0 0 1 1 1 1 F subunit of K+-transporting ATPase (Potass_KdpF) Thioredoxin PF00085.20 CDK99048.1 - 1.1e-33 115.3 0.0 1.2e-33 115.2 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CDK99048.1 - 3.6e-08 33.6 0.0 3.9e-06 27.1 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 CDK99048.1 - 8.3e-08 32.7 0.0 1e-06 29.1 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 CDK99048.1 - 5.8e-06 26.2 0.0 6.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDK99048.1 - 0.00011 22.0 0.0 0.00017 21.4 0.0 1.4 1 1 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 CDK99048.1 - 0.00012 22.2 0.0 0.00014 21.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 CDK99048.1 - 0.00016 21.4 0.0 0.00018 21.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 CDK99048.1 - 0.00069 19.6 0.0 0.00086 19.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain TraF PF13728.6 CDK99048.1 - 0.0012 18.8 0.0 0.0014 18.5 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein DUF836 PF05768.14 CDK99048.1 - 0.0043 17.4 0.0 0.0053 17.1 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) OST3_OST6 PF04756.13 CDK99048.1 - 0.0094 15.3 0.0 0.011 15.1 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 CDK99048.1 - 0.048 13.6 0.0 0.05 13.5 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain DUF938 PF06080.12 CDK99049.1 - 4.6e-74 248.6 0.0 5.4e-74 248.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_25 PF13649.6 CDK99049.1 - 0.0014 19.3 0.0 0.003 18.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK99049.1 - 0.17 12.6 0.0 0.58 10.8 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain Rrf2 PF02082.20 CDK99050.1 - 1.2e-22 80.0 0.0 1.9e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator HrcA_DNA-bdg PF03444.15 CDK99050.1 - 0.00071 19.2 0.0 0.0013 18.3 0.0 1.5 2 0 0 2 2 2 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding GntR PF00392.21 CDK99050.1 - 0.0052 16.4 0.1 0.018 14.7 0.0 1.8 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_Crp_2 PF13545.6 CDK99050.1 - 0.0066 16.4 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain DUF1922 PF09082.10 CDK99050.1 - 0.084 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1922) FMN_red PF03358.15 CDK99051.1 - 4.3e-16 59.0 1.6 3.1e-15 56.3 1.6 2.2 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_5 PF12724.7 CDK99051.1 - 3.7e-10 40.2 0.1 5.2e-10 39.7 0.1 1.3 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_1 PF00258.25 CDK99051.1 - 3.3e-05 24.1 0.0 4.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_2 PF02525.17 CDK99051.1 - 0.00018 21.3 0.3 0.00039 20.2 0.3 1.8 1 1 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_3 PF12641.7 CDK99051.1 - 0.021 14.5 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin domain adh_short_C2 PF13561.6 CDK99052.1 - 2.9e-59 200.5 2.5 3.4e-59 200.2 2.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDK99052.1 - 1e-56 191.5 1.7 1.3e-56 191.2 1.7 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDK99052.1 - 1.2e-18 67.6 0.5 2.2e-18 66.8 0.5 1.3 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CDK99052.1 - 7.5e-06 26.0 0.1 1.1e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CDK99052.1 - 6.2e-05 22.6 0.4 0.0002 20.9 0.4 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Thiolase_N PF00108.23 CDK99053.1 - 4.7e-102 340.8 8.7 6.1e-102 340.4 8.7 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDK99053.1 - 2.3e-52 175.8 1.0 2.3e-52 175.8 1.0 2.1 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CDK99053.1 - 0.00031 20.4 3.8 0.00031 20.4 3.8 3.1 3 1 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CDK99053.1 - 0.37 10.7 2.7 16 5.4 0.3 2.9 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Abhydrolase_1 PF00561.20 CDK99054.1 - 1e-09 38.4 0.0 1.4e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDK99054.1 - 2.3e-06 27.0 0.0 0.00046 19.5 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 PhaC_N PF07167.13 CDK99054.1 - 2.8e-05 23.8 0.0 4.1e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus DLH PF01738.18 CDK99054.1 - 0.00098 18.7 0.0 0.038 13.6 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family Chlorophyllase PF07224.11 CDK99054.1 - 0.023 13.7 0.0 0.034 13.2 0.0 1.1 1 0 0 1 1 1 0 Chlorophyllase Chlorophyllase2 PF12740.7 CDK99054.1 - 0.078 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Esterase PF00756.20 CDK99054.1 - 0.083 12.5 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Abhydrolase_4 PF08386.10 CDK99054.1 - 0.18 11.9 0.0 0.38 10.9 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein PHB_acc_N PF07879.11 CDK99056.1 - 2e-31 107.9 0.9 3.2e-31 107.2 0.9 1.3 1 0 0 1 1 1 1 PHB/PHA accumulation regulator DNA-binding domain PHB_acc PF05233.13 CDK99056.1 - 7.4e-16 57.9 0.1 7.4e-16 57.9 0.1 3.1 3 0 0 3 3 3 1 PHB accumulation regulatory domain TrbI PF03743.14 CDK99057.1 - 0.063 13.1 2.1 0.072 12.9 2.1 1.1 1 0 0 1 1 1 0 Bacterial conjugation TrbI-like protein EAL PF00563.20 CDK99058.1 - 1.7e-58 198.0 0.0 2.4e-58 197.5 0.0 1.2 1 0 0 1 1 1 1 EAL domain PAS_4 PF08448.10 CDK99058.1 - 3.3e-07 30.5 0.2 1.9e-06 28.1 0.0 2.3 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 CDK99058.1 - 1.1e-05 25.4 0.0 2.3e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDK99058.1 - 0.0096 16.2 0.0 0.025 14.8 0.0 1.7 1 0 0 1 1 1 1 PAS domain HTH_3 PF01381.22 CDK99059.1 - 1.3e-15 57.2 0.3 2.8e-15 56.1 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_19 PF12844.7 CDK99059.1 - 2e-12 46.9 0.0 3e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 CDK99059.1 - 7.1e-11 42.3 0.1 7.5e-10 39.0 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_26 PF13443.6 CDK99059.1 - 0.00056 20.3 0.0 0.0011 19.4 0.0 1.5 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_Crp_2 PF13545.6 CDK99059.1 - 0.0036 17.2 0.1 0.012 15.5 0.0 2.0 3 0 0 3 3 3 1 Crp-like helix-turn-helix domain Sigma70_r4_2 PF08281.12 CDK99059.1 - 0.004 16.8 0.0 8.5 6.1 0.0 3.4 3 0 0 3 3 3 1 Sigma-70, region 4 MqsA_antitoxin PF15731.5 CDK99059.1 - 0.012 15.7 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_37 PF13744.6 CDK99059.1 - 0.018 15.0 1.0 0.066 13.2 0.0 2.1 2 1 0 2 2 2 0 Helix-turn-helix domain Sigma70_r4 PF04545.16 CDK99059.1 - 0.029 13.9 0.2 7.6 6.2 0.0 3.2 3 0 0 3 3 3 0 Sigma-70, region 4 Pou PF00157.17 CDK99059.1 - 0.029 14.3 0.2 0.063 13.2 0.1 1.6 2 0 0 2 2 2 0 Pou domain - N-terminal to homeobox domain YdaS_antitoxin PF15943.5 CDK99059.1 - 0.033 14.0 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DUF1730 PF08331.10 CDK99060.1 - 3.7e-21 74.8 0.0 6.3e-21 74.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1730) Fer4_16 PF13484.6 CDK99060.1 - 5e-19 69.0 4.0 7.8e-19 68.4 4.0 1.3 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_7 PF12838.7 CDK99060.1 - 1.5e-08 35.1 5.0 3.1e-08 34.1 5.0 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK99060.1 - 4.5e-07 29.9 5.1 0.0023 18.0 1.4 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDK99060.1 - 3.7e-06 27.0 2.8 0.0022 18.1 0.3 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 CDK99060.1 - 5.8e-06 25.9 11.8 3.8e-05 23.3 3.1 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 CDK99060.1 - 0.00011 22.5 1.9 0.032 14.7 0.7 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDK99060.1 - 0.00055 20.7 12.6 0.053 14.5 5.4 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 CDK99060.1 - 0.0026 17.8 15.1 0.046 13.8 3.5 2.5 2 1 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 CDK99060.1 - 0.0027 17.8 5.5 0.15 12.2 1.8 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 CDK99060.1 - 0.0076 16.7 9.2 0.88 10.2 4.2 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 CDK99060.1 - 0.014 15.4 14.4 0.018 15.1 5.2 2.8 3 0 0 3 3 3 0 4Fe-4S binding domain HEAT_2 PF13646.6 CDK99060.1 - 0.032 14.6 0.1 0.08 13.3 0.1 1.7 1 0 0 1 1 1 0 HEAT repeats Fer4_17 PF13534.6 CDK99060.1 - 0.066 13.8 7.8 0.31 11.6 8.2 1.9 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDK99060.1 - 0.089 13.0 3.6 0.74 10.0 0.9 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain QueF PF14489.6 CDK99061.1 - 1.8e-32 111.3 0.0 2.3e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 QueF-like protein QueF_N PF14819.6 CDK99061.1 - 0.00099 19.4 0.0 0.0014 18.9 0.0 1.2 1 0 0 1 1 1 1 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term PfkB PF00294.24 CDK99062.1 - 6.2e-38 130.8 3.3 8.4e-38 130.4 3.3 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase CTP_transf_like PF01467.26 CDK99062.1 - 1.6e-13 51.1 0.0 2.8e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like Phos_pyr_kin PF08543.12 CDK99062.1 - 6.7e-08 32.2 0.8 1.2e-07 31.4 0.1 1.7 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase Carb_kinase PF01256.17 CDK99062.1 - 0.00023 20.7 2.0 0.00069 19.2 0.5 2.1 2 0 0 2 2 2 1 Carbohydrate kinase Pantoate_ligase PF02569.15 CDK99062.1 - 0.0048 16.2 0.0 0.0086 15.3 0.0 1.3 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Tic110 PF16940.5 CDK99062.1 - 0.68 8.4 3.8 1.1 7.7 3.8 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter Metallophos PF00149.28 CDK99063.1 - 2.1e-13 51.2 0.1 3e-13 50.8 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FlaF PF07309.11 CDK99066.1 - 2.4e-12 46.9 2.1 2.6e-12 46.7 2.1 1.0 1 0 0 1 1 1 1 Flagellar protein FlaF GDP_Man_Dehyd PF16363.5 CDK99067.1 - 1.9e-83 280.6 0.0 2.2e-83 280.4 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDK99067.1 - 4.2e-69 232.7 0.0 5.5e-69 232.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDK99067.1 - 2.3e-18 66.3 0.0 3.6e-18 65.7 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CDK99067.1 - 1.4e-14 53.9 0.0 2.6e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CDK99067.1 - 6.5e-11 41.9 0.0 5.6e-08 32.3 0.0 2.3 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.25 CDK99067.1 - 1.5e-10 40.9 2.1 6.1e-07 29.1 0.4 2.4 2 1 0 2 2 2 2 short chain dehydrogenase 3Beta_HSD PF01073.19 CDK99067.1 - 2e-10 40.1 0.0 3.3e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 CDK99067.1 - 3.4e-05 23.8 0.7 6.8e-05 22.8 0.1 1.7 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 CDK99067.1 - 0.0001 22.3 0.2 0.0002 21.3 0.2 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CDK99067.1 - 0.004 17.4 0.1 0.0066 16.7 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 CDK99067.1 - 0.021 14.4 0.1 0.03 13.9 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family adh_short_C2 PF13561.6 CDK99067.1 - 0.041 13.4 0.7 1 8.9 0.1 2.2 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase AMP-binding PF00501.28 CDK99068.1 - 5.9e-36 124.0 0.0 7.4e-36 123.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDK99068.1 - 1e-05 26.4 2.0 1.2e-05 26.2 0.0 2.1 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain Glyco_hydro_114 PF03537.13 CDK99069.1 - 0.00027 20.3 0.1 0.0006 19.2 0.1 1.6 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 Response_reg PF00072.24 CDK99069.1 - 0.17 12.1 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 Response regulator receiver domain DAO PF01266.24 CDK99070.1 - 5.8e-58 197.2 7.0 6.5e-58 197.0 7.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDK99070.1 - 9.7e-08 32.1 2.9 9.7e-08 32.1 2.9 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CDK99070.1 - 3.4e-06 26.6 0.7 1e-05 25.1 1.0 1.6 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CDK99070.1 - 0.00018 21.0 3.2 0.00029 20.3 3.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CDK99070.1 - 0.00021 20.6 4.5 0.00046 19.5 4.2 1.8 1 1 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CDK99070.1 - 0.00086 18.5 3.7 0.0016 17.6 3.7 1.4 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 CDK99070.1 - 0.0066 15.8 0.8 0.0066 15.8 0.8 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 CDK99070.1 - 0.017 14.3 2.0 0.017 14.3 2.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CDK99070.1 - 0.028 13.7 2.0 0.053 12.8 2.0 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 CDK99070.1 - 0.042 12.5 5.3 0.085 11.5 4.1 1.9 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 CDK99070.1 - 0.059 13.9 1.6 0.14 12.7 1.6 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CDK99070.1 - 0.06 13.2 1.2 0.099 12.5 1.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CDK99070.1 - 0.079 12.5 0.6 0.12 11.9 0.6 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GIDA PF01134.22 CDK99070.1 - 0.13 11.3 2.7 0.19 10.8 2.7 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CDK99070.1 - 0.59 9.3 4.9 1.3 8.2 4.8 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Molybdopterin PF00384.22 CDK99071.1 - 1.2e-56 192.5 0.0 2e-56 191.8 0.0 1.3 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 CDK99071.1 - 1.3e-20 73.4 0.0 3.4e-20 72.1 0.0 1.7 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Molybdop_Fe4S4 PF04879.16 CDK99071.1 - 1.3e-05 25.1 0.5 2.1e-05 24.4 0.5 1.4 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Fe4S4 domain MipZ PF09140.11 CDK99072.1 - 3.3e-109 364.2 0.5 3.8e-109 364.0 0.5 1.0 1 0 0 1 1 1 1 ATPase MipZ CbiA PF01656.23 CDK99072.1 - 2.2e-09 37.4 0.0 3.8e-09 36.7 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDK99072.1 - 5.2e-09 36.3 0.1 2.6e-07 30.7 0.1 2.2 1 1 1 2 2 2 1 AAA domain ParA PF10609.9 CDK99072.1 - 2.2e-08 33.9 0.1 1e-07 31.7 0.1 1.9 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CLP1_P PF16575.5 CDK99072.1 - 0.0016 18.2 0.0 0.024 14.4 0.1 2.2 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop LpxK PF02606.14 CDK99072.1 - 0.0026 16.9 0.0 0.004 16.3 0.0 1.3 1 0 0 1 1 1 1 Tetraacyldisaccharide-1-P 4'-kinase AAA_26 PF13500.6 CDK99072.1 - 0.02 14.7 0.1 0.057 13.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 CDK99072.1 - 0.02 14.2 0.7 0.048 13.0 0.7 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family VirC1 PF07015.11 CDK99072.1 - 0.031 13.6 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 VirC1 protein MobB PF03205.14 CDK99072.1 - 0.1 12.5 0.1 0.27 11.1 0.1 1.8 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 CDK99072.1 - 0.13 11.2 0.1 0.34 9.8 0.2 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB EAL PF00563.20 CDK99073.1 - 4.1e-77 258.9 0.0 7.5e-77 258.1 0.0 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK99073.1 - 2.3e-55 186.7 0.0 5.4e-55 185.5 0.0 1.7 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain CBS PF00571.28 CDK99073.1 - 2.2e-37 127.3 4.1 3.3e-09 37.0 0.0 4.9 5 0 0 5 5 5 4 CBS domain PAS_9 PF13426.7 CDK99073.1 - 2.3e-18 66.3 0.0 5.3e-18 65.2 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CDK99073.1 - 6.4e-12 45.5 0.0 1.5e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK99073.1 - 1.2e-07 31.6 0.0 8.1e-07 28.9 0.0 2.5 3 0 0 3 3 3 1 PAS domain PAS_3 PF08447.12 CDK99073.1 - 4.1e-06 27.0 0.1 8.5e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDK99073.1 - 2.9e-05 24.3 0.0 0.00018 21.7 0.0 2.4 2 0 0 2 2 2 1 PAS fold Hpt PF01627.23 CDK99074.1 - 1.5e-09 38.0 0.5 2.6e-09 37.2 0.5 1.4 1 0 0 1 1 1 1 Hpt domain Response_reg PF00072.24 CDK99074.1 - 3e-06 27.4 0.0 6.2e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Spidroin_N PF16763.5 CDK99074.1 - 0.074 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term BPD_transp_1 PF00528.22 CDK99075.1 - 6.9e-16 58.5 15.6 6.9e-16 58.5 15.6 1.7 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 CDK99076.1 - 6.9e-17 61.8 12.3 6.9e-17 61.8 12.3 2.1 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component DUF4229 PF14012.6 CDK99076.1 - 0.23 11.6 0.2 0.23 11.6 0.2 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF4229) ABC_tran PF00005.27 CDK99077.1 - 2.9e-34 118.5 0.0 4.3e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter TOBE_2 PF08402.10 CDK99077.1 - 5.2e-19 68.2 0.5 5.2e-19 68.2 0.5 2.5 3 0 0 3 3 2 1 TOBE domain AAA_21 PF13304.6 CDK99077.1 - 3.6e-07 30.3 0.0 0.00064 19.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK99077.1 - 0.00014 21.4 0.1 0.0012 18.3 0.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_5 PF07728.14 CDK99077.1 - 0.0047 16.9 0.2 0.54 10.3 0.1 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDK99077.1 - 0.0081 16.4 0.1 0.026 14.8 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CDK99077.1 - 0.0083 16.5 0.4 0.2 12.1 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDK99077.1 - 0.0095 16.3 0.0 0.028 14.8 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 CDK99077.1 - 0.038 13.6 0.3 0.16 11.5 0.3 2.1 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDK99077.1 - 0.04 13.8 0.1 0.099 12.5 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 CDK99077.1 - 0.046 13.5 0.1 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 CDK99077.1 - 0.074 13.0 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_28 PF13521.6 CDK99077.1 - 0.11 12.8 0.2 0.29 11.4 0.2 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDK99077.1 - 0.12 12.9 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDK99077.1 - 0.21 12.0 0.0 1.5 9.3 0.0 2.3 2 1 0 2 2 2 0 RNA helicase CysA_C_terminal PF17850.1 CDK99077.1 - 0.22 12.1 3.8 0.27 11.8 0.0 3.2 4 0 0 4 4 3 0 CysA C-terminal regulatory domain SBP_bac_8 PF13416.6 CDK99078.1 - 6.1e-32 111.6 1.6 7.5e-32 111.3 1.6 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 CDK99078.1 - 7.1e-25 87.8 0.4 1.1e-24 87.2 0.4 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CDK99078.1 - 9.7e-18 65.2 3.7 2.1e-17 64.1 3.7 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CDK99078.1 - 1.2e-10 41.5 0.1 2.7e-10 40.4 0.1 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3584 PF12128.8 CDK99079.1 - 0.0035 15.0 3.2 0.0042 14.7 3.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Baculo_PEP_C PF04513.12 CDK99079.1 - 0.02 14.9 0.4 0.21 11.6 0.4 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Borrelia_REV PF03978.13 CDK99079.1 - 0.027 14.4 2.9 0.033 14.1 2.9 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein Transcrip_act PF04949.13 CDK99079.1 - 0.032 14.1 2.7 0.053 13.4 2.7 1.3 1 1 0 1 1 1 0 Transcriptional activator CDC37_N PF03234.14 CDK99079.1 - 0.045 14.7 2.0 6.2 7.8 2.0 2.3 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding Apolipoprotein PF01442.18 CDK99079.1 - 0.046 13.6 4.2 0.097 12.5 4.2 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain LapA_dom PF06305.11 CDK99079.1 - 0.062 13.1 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Bacillus_HBL PF05791.11 CDK99079.1 - 0.069 13.0 1.8 0.16 11.8 1.8 1.6 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Phasin PF05597.11 CDK99079.1 - 0.099 12.7 4.1 0.087 12.8 2.0 1.7 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) FUSC PF04632.12 CDK99079.1 - 0.1 11.1 2.2 0.15 10.6 2.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family NPA PF16469.5 CDK99079.1 - 0.11 13.1 2.6 0.18 12.4 2.6 1.4 1 0 0 1 1 1 0 Nematode polyprotein allergen ABA-1 OmpH PF03938.14 CDK99079.1 - 0.32 11.3 7.4 0.7 10.2 3.1 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 CDK99079.1 - 0.41 9.9 5.4 0.62 9.4 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Herpes_UL25 PF01499.16 CDK99079.1 - 0.45 9.0 2.6 0.53 8.7 2.6 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family XhlA PF10779.9 CDK99079.1 - 4.1 7.7 7.6 6.6 7.0 0.1 2.8 2 1 0 2 2 2 0 Haemolysin XhlA GDE_C PF06202.14 CDK99081.1 - 2.1e-123 412.0 0.0 2.8e-123 411.6 0.0 1.1 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase GDE_N PF12439.8 CDK99081.1 - 2.2e-43 148.2 0.0 3.7e-43 147.5 0.0 1.3 1 0 0 1 1 1 1 Glycogen debranching enzyme N terminal Bac_rhamnosid6H PF17389.2 CDK99081.1 - 0.0011 18.3 0.1 0.0019 17.5 0.1 1.4 1 1 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain MCPsignal PF00015.21 CDK99082.1 - 1.9e-29 102.7 15.6 1.1e-27 96.9 10.2 2.9 1 1 2 3 3 3 3 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF948 PF06103.11 CDK99082.1 - 1.2e-06 28.7 4.5 0.26 11.6 0.1 4.7 2 2 2 4 4 4 2 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 CDK99082.1 - 0.00031 20.8 3.2 0.49 10.4 0.2 3.4 2 1 0 2 2 2 2 Laminin Domain II DUF1664 PF07889.12 CDK99082.1 - 0.00034 20.6 2.2 1.5 8.8 0.1 3.8 2 2 2 4 4 4 2 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 CDK99082.1 - 0.00039 20.8 3.3 6.6 7.3 0.1 4.6 4 1 1 5 5 4 1 Nucleopolyhedrovirus P10 protein LXG PF04740.12 CDK99082.1 - 0.006 16.3 0.8 0.082 12.6 0.1 2.7 1 1 0 2 2 2 1 LXG domain of WXG superfamily BLOC1_2 PF10046.9 CDK99082.1 - 0.0073 16.6 0.6 14 6.1 0.0 4.1 3 1 2 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DHR10 PF18595.1 CDK99082.1 - 0.022 14.8 0.1 6.4 6.9 0.0 3.2 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain ThiD2 PF17792.1 CDK99082.1 - 0.032 14.7 0.0 0.091 13.2 0.0 1.7 1 0 0 1 1 1 0 ThiD2 family Vps53_N PF04100.12 CDK99082.1 - 0.034 13.1 2.8 0.19 10.7 0.2 2.3 2 0 0 2 2 2 0 Vps53-like, N-terminal Sec34 PF04136.15 CDK99082.1 - 0.056 13.3 0.1 8.8 6.2 0.1 3.0 3 1 0 3 3 3 0 Sec34-like family T7SS_ESX_EspC PF10824.8 CDK99082.1 - 0.17 12.4 7.7 6.4 7.3 0.2 3.7 1 1 3 4 4 4 0 Excreted virulence factor EspC, type VII ESX diderm Prominin PF05478.11 CDK99082.1 - 0.22 9.5 0.1 0.33 8.8 0.1 1.4 1 0 0 1 1 1 0 Prominin DivIVA PF05103.13 CDK99082.1 - 0.22 11.6 0.7 9.4 6.3 0.1 3.1 2 1 1 3 3 3 0 DivIVA protein ISG65-75 PF11727.8 CDK99082.1 - 0.26 10.5 1.0 0.78 8.9 0.1 2.1 1 1 2 3 3 3 0 Invariant surface glycoprotein Senescence PF06911.12 CDK99082.1 - 0.98 9.7 7.8 2.3 8.5 3.9 2.5 1 1 0 2 2 2 0 Senescence-associated protein FlaC_arch PF05377.11 CDK99082.1 - 1.3 9.4 4.7 53 4.3 0.1 4.1 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) MCPsignal PF00015.21 CDK99083.1 - 1.4e-30 106.3 30.2 1.3e-28 100.0 20.9 2.9 1 1 2 3 3 3 3 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CDK99083.1 - 5.5e-11 42.7 0.4 1.8e-07 31.2 0.0 3.8 4 1 0 4 4 4 2 Cache domain HAMP PF00672.25 CDK99083.1 - 2.2e-07 31.1 1.2 2.2e-07 31.1 1.2 4.1 3 0 0 3 3 3 1 HAMP domain CheZ PF04344.13 CDK99083.1 - 0.0014 18.6 5.0 0.029 14.3 0.0 3.4 2 1 1 3 3 3 1 Chemotaxis phosphatase, CheZ Flagellar_rod PF05149.12 CDK99083.1 - 0.06 12.8 4.2 5.3 6.4 0.0 2.5 2 0 0 2 2 2 0 Paraflagellar rod protein Laminin_II PF06009.12 CDK99083.1 - 1.4 9.0 7.3 0.65 10.0 0.7 3.2 1 1 0 3 3 3 0 Laminin Domain II DUF948 PF06103.11 CDK99083.1 - 2 8.7 24.6 0.38 11.0 0.5 5.7 4 1 2 6 6 6 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 CDK99083.1 - 5.6 7.0 8.2 8.1 6.5 0.2 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Acetyltransf_4 PF13420.7 CDK99084.1 - 8.6e-27 94.2 0.0 9.8e-27 94.0 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDK99084.1 - 1.7e-14 54.1 0.0 2.1e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CDK99084.1 - 1.1e-10 42.3 0.0 1.3e-10 42.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDK99084.1 - 1.8e-09 37.9 0.0 2.8e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDK99084.1 - 5.3e-08 32.9 0.0 7.2e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 CDK99084.1 - 0.0025 18.0 0.2 0.0039 17.4 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDK99084.1 - 0.067 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.6 CDK99084.1 - 0.12 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.6 CDK99084.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain OMP_b-brl PF13505.6 CDK99085.1 - 0.00071 19.7 6.7 0.011 15.9 6.7 2.0 1 1 0 1 1 1 1 Outer membrane protein beta-barrel domain Hemerythrin PF01814.23 CDK99086.1 - 7.1e-15 55.8 0.4 7.9e-15 55.6 0.4 1.0 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain PRT_C PF08372.10 CDK99086.1 - 0.0056 16.4 0.1 2.7 7.7 0.0 2.1 2 0 0 2 2 2 2 Plant phosphoribosyltransferase C-terminal ABATE PF07336.11 CDK99086.1 - 0.14 12.9 3.6 0.19 12.4 3.6 1.4 1 1 0 1 1 1 0 Putative stress-induced transcription regulator Peptidase_S11 PF00768.20 CDK99087.1 - 4.6e-59 199.8 0.0 6.1e-59 199.4 0.0 1.1 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 CDK99087.1 - 1.4e-11 44.4 0.4 2.4e-11 43.6 0.4 1.3 1 0 0 1 1 1 1 Beta-lactamase enzyme family Peptidase_S13 PF02113.15 CDK99087.1 - 0.00072 18.4 2.1 0.0057 15.4 0.2 2.1 1 1 1 2 2 2 2 D-Ala-D-Ala carboxypeptidase 3 (S13) family Beta-lactamase PF00144.24 CDK99087.1 - 0.02 14.2 1.4 2.9 7.0 0.4 2.4 2 0 0 2 2 2 0 Beta-lactamase DUF2721 PF11026.8 CDK99088.1 - 0.041 13.8 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) SBP_bac_3 PF00497.20 CDK99089.1 - 1.3e-35 122.8 0.0 1.5e-35 122.6 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 HATPase_c PF02518.26 CDK99090.1 - 5.7e-26 91.2 0.0 1.2e-25 90.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_4 PF08448.10 CDK99090.1 - 1.7e-18 66.9 2.8 2.2e-08 34.3 0.4 2.8 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 CDK99090.1 - 2.8e-14 53.2 0.0 5.3e-07 29.8 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.7 CDK99090.1 - 1.3e-13 50.6 0.1 6.1e-06 26.1 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 CDK99090.1 - 3.5e-13 49.5 0.0 4.5e-05 23.4 0.0 3.0 3 0 0 3 3 3 2 PAS fold HisKA PF00512.25 CDK99090.1 - 4.7e-12 45.8 0.2 1.9e-11 43.8 0.2 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 CDK99090.1 - 8e-09 35.7 0.1 3.7e-07 30.3 0.0 3.2 3 0 0 3 3 3 1 PAS fold HATPase_c_5 PF14501.6 CDK99090.1 - 0.0041 17.0 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 GHKL domain PAS_11 PF14598.6 CDK99090.1 - 0.1 12.7 0.0 0.28 11.3 0.0 1.8 1 0 0 1 1 1 0 PAS domain PAS_3 PF08447.12 CDK99091.1 - 1e-12 48.2 0.0 1.5e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CDK99091.1 - 8.1e-11 41.9 0.0 1.4e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDK99091.1 - 1.1e-10 41.6 0.0 2.2e-10 40.7 0.0 1.4 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 CDK99091.1 - 2.1e-08 34.4 0.0 3e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK99091.1 - 0.017 15.2 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 PAS domain DUF834 PF05754.14 CDK99091.1 - 0.071 13.1 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF834) MCPsignal PF00015.21 CDK99092.1 - 6.6e-31 107.4 28.2 6.6e-31 107.4 28.2 3.9 2 2 1 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK99092.1 - 3.9e-05 23.9 0.7 3.9e-05 23.9 0.7 5.5 6 0 0 6 6 6 1 HAMP domain Nitrate_red_gam PF02665.14 CDK99092.1 - 0.093 12.3 4.7 2.2 7.8 0.2 2.7 3 0 0 3 3 3 0 Nitrate reductase gamma subunit Fib_alpha PF08702.10 CDK99092.1 - 0.41 10.8 5.2 1.1 9.4 0.1 3.3 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 CDK99092.1 - 0.56 9.5 21.4 0.31 10.3 1.3 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 CDK99092.1 - 0.57 10.2 18.0 0.2 11.7 3.0 4.3 5 1 0 5 5 5 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 CDK99092.1 - 0.76 10.1 33.4 0.13 12.5 1.8 7.1 6 2 0 7 7 7 0 Bacterial protein of unknown function (DUF948) DUF4064 PF13273.6 CDK99092.1 - 2.9 8.2 9.8 0.45 10.8 0.2 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF4064) COG5 PF10392.9 CDK99092.1 - 4 7.6 6.1 37 4.5 0.2 4.0 4 0 0 4 4 4 0 Golgi transport complex subunit 5 STAS PF01740.21 CDK99093.1 - 4.5e-12 45.6 0.0 4.8e-12 45.5 0.0 1.0 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 CDK99093.1 - 1.8e-08 34.6 0.1 2e-08 34.4 0.1 1.1 1 0 0 1 1 1 1 STAS domain SpoIIE PF07228.12 CDK99094.1 - 1.8e-35 122.6 0.1 2.8e-35 122.0 0.1 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Response_reg PF00072.24 CDK99094.1 - 1.1e-25 89.9 0.1 2e-25 89.1 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c_2 PF13581.6 CDK99094.1 - 2.2e-12 47.0 0.0 4.6e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c PF02518.26 CDK99094.1 - 0.21 12.1 0.0 0.46 11.0 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase adh_short PF00106.25 CDK99095.1 - 7e-39 133.3 0.2 8.7e-39 133.0 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDK99095.1 - 9.5e-25 87.5 0.5 1.1e-24 87.3 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDK99095.1 - 2.5e-07 30.8 0.2 3.6e-07 30.3 0.2 1.1 1 0 0 1 1 1 1 KR domain DUF86 PF01934.17 CDK99096.1 - 1.4e-26 92.7 0.0 1.6e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF86 NTP_transf_2 PF01909.23 CDK99097.1 - 7.6e-12 45.4 0.0 1.2e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 CDK99097.1 - 1.5e-11 44.2 0.0 2.3e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase DUF4349 PF14257.6 CDK99097.1 - 0.12 11.8 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Response_reg PF00072.24 CDK99098.1 - 3.5e-07 30.4 0.0 6.2e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain YicC_N PF03755.13 CDK99099.1 - 3.9e-35 121.5 0.7 6.9e-35 120.7 0.0 1.7 2 0 0 2 2 2 1 YicC-like family, N-terminal region DUF1732 PF08340.11 CDK99099.1 - 1.6e-33 114.5 0.1 3.6e-33 113.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1732) Cluap1 PF10234.9 CDK99099.1 - 0.063 12.7 0.9 0.086 12.2 0.1 1.6 2 0 0 2 2 2 0 Clusterin-associated protein-1 DUF2158 PF09926.9 CDK99099.1 - 0.086 12.6 0.0 0.4 10.5 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized small protein (DUF2158) Guanylate_kin PF00625.21 CDK99100.1 - 1.5e-52 177.9 0.0 1.8e-52 177.7 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 CDK99100.1 - 4.4e-05 23.7 0.0 0.00016 21.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CDK99100.1 - 0.0043 17.1 0.0 0.01 15.9 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 CDK99100.1 - 0.015 15.9 0.0 0.043 14.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 CDK99100.1 - 0.086 12.6 0.0 0.096 12.4 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CDK99100.1 - 0.1 12.9 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CDK99100.1 - 0.11 12.4 0.0 0.47 10.4 0.0 2.1 3 0 0 3 3 3 0 Rad17 P-loop domain ABC_tran PF00005.27 CDK99100.1 - 0.13 12.8 0.0 0.16 12.5 0.0 1.5 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 CDK99100.1 - 0.18 11.7 0.0 0.44 10.4 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase CPT PF07931.12 CDK99100.1 - 0.2 11.5 1.0 0.7 9.7 0.2 2.3 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein Glyco_transf_9 PF01075.17 CDK99101.1 - 1.1e-19 70.8 0.0 1.5e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) Pribosyltran PF00156.27 CDK99102.1 - 1.6e-18 66.7 0.0 2e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CDK99102.1 - 0.0036 16.8 0.0 0.0042 16.6 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PAS_7 PF12860.7 CDK99103.1 - 9.2e-54 180.5 0.3 1.4e-32 112.3 0.0 4.7 4 0 0 4 4 4 3 PAS fold PAS_4 PF08448.10 CDK99103.1 - 8.3e-32 109.7 4.4 2.1e-10 40.8 0.0 4.9 4 2 0 4 4 4 4 PAS fold HATPase_c PF02518.26 CDK99103.1 - 1.1e-28 100.0 0.0 2.1e-28 99.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 CDK99103.1 - 4.4e-26 91.1 0.0 2.2e-15 56.6 0.0 4.0 3 0 0 3 3 3 3 PAS fold PAS_9 PF13426.7 CDK99103.1 - 2.3e-24 85.6 0.0 6.6e-15 55.2 0.0 4.2 4 1 0 4 4 4 2 PAS domain PAS_8 PF13188.7 CDK99103.1 - 1.2e-18 66.6 2.3 1.6e-05 24.8 0.0 4.9 4 0 0 4 4 4 4 PAS domain HisKA PF00512.25 CDK99103.1 - 1.8e-18 66.3 0.0 1.8e-18 66.3 0.0 3.8 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 CDK99103.1 - 8.3e-05 22.8 0.0 0.095 13.0 0.0 2.8 2 0 0 2 2 2 2 PAS fold HATPase_c_2 PF13581.6 CDK99103.1 - 0.00087 19.2 0.0 0.002 18.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain PAS_10 PF13596.6 CDK99103.1 - 0.0016 19.0 0.0 1.2 9.8 0.0 3.8 4 0 0 4 4 4 1 PAS domain HATPase_c_3 PF13589.6 CDK99103.1 - 0.012 15.5 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1771 PF08590.10 CDK99103.1 - 0.15 12.5 0.0 0.4 11.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) Glyco_hydro_1 PF00232.18 CDK99105.1 - 1.4e-145 485.2 0.0 1.7e-145 485.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_cc PF11790.8 CDK99105.1 - 0.0042 16.7 0.0 0.23 11.0 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase catalytic core DDE_3 PF13358.6 CDK99106.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK99106.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDK99107.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK99107.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK99107.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK99107.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK99107.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK99107.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain HTH_21 PF13276.6 CDK99109.1 - 1.8e-12 47.2 8.1 1.8e-12 47.2 8.1 2.1 1 1 1 2 2 2 1 HTH-like domain rve PF00665.26 CDK99110.1 - 0.011 15.9 0.2 0.014 15.6 0.2 1.3 1 1 0 1 1 1 0 Integrase core domain PhoU PF01895.19 CDK99111.1 - 0.033 14.7 0.2 0.7 10.4 0.0 2.1 2 0 0 2 2 2 0 PhoU domain DNA_methylase PF00145.17 CDK99113.1 - 3.2e-32 112.2 0.0 4.7e-21 75.5 0.0 2.1 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase DUF4010 PF13194.6 CDK99114.1 - 0.12 12.0 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) Zn_Tnp_IS1595 PF12760.7 CDK99115.1 - 1.5e-10 40.9 4.2 2.8e-10 40.0 4.2 1.5 1 0 0 1 1 1 1 Transposase zinc-ribbon domain DDE_Tnp_IS1595 PF12762.7 CDK99115.1 - 5.3e-10 39.5 0.0 7.9e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain A2L_zn_ribbon PF08792.10 CDK99115.1 - 0.049 13.4 5.1 0.22 11.3 0.8 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain Zn-ribbon_8 PF09723.10 CDK99115.1 - 0.37 10.9 7.4 2.9 8.1 0.7 2.5 1 1 1 2 2 2 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 CDK99115.1 - 1.4 8.4 7.9 0.72 9.4 3.0 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding PAS_9 PF13426.7 CDK99117.1 - 1.2e-35 121.9 0.0 1.8e-17 63.5 0.0 3.2 3 0 0 3 3 3 2 PAS domain PAS PF00989.25 CDK99117.1 - 8.3e-29 99.9 0.0 1.6e-14 53.9 0.0 3.6 3 0 0 3 3 3 3 PAS fold HATPase_c PF02518.26 CDK99117.1 - 1.1e-22 80.7 0.0 3.2e-22 79.1 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 CDK99117.1 - 9.8e-22 77.1 1.5 4.1e-10 39.8 0.1 3.9 4 0 0 4 4 4 2 PAS fold PAS_4 PF08448.10 CDK99117.1 - 2.1e-20 73.0 0.0 1.5e-10 41.2 0.0 3.5 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.7 CDK99117.1 - 1.5e-14 53.6 0.0 1.3e-06 28.3 0.0 2.9 2 0 0 2 2 2 2 PAS domain dCache_1 PF02743.18 CDK99117.1 - 1.4e-12 48.0 0.0 4.4e-12 46.3 0.0 1.8 2 0 0 2 2 2 1 Cache domain HisKA PF00512.25 CDK99117.1 - 3.5e-09 36.6 1.9 8.8e-09 35.3 0.2 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDK99117.1 - 6.8e-09 36.0 0.3 4e-08 33.5 0.3 2.3 2 0 0 2 2 2 1 HAMP domain PAS_7 PF12860.7 CDK99117.1 - 0.0088 16.2 0.1 2.9 8.1 0.0 3.6 3 1 0 3 3 3 1 PAS fold HATPase_c_5 PF14501.6 CDK99117.1 - 0.061 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 GHKL domain PAS_12 PF18095.1 CDK99117.1 - 0.11 12.1 0.0 3.8 7.1 0.0 2.3 2 0 0 2 2 2 0 UPF0242 C-terminal PAS-like domain Phage_portal_2 PF05136.13 CDK99118.1 - 0.0004 19.7 0.1 0.00045 19.5 0.1 1.1 1 0 0 1 1 1 1 Phage portal protein, lambda family CwsA PF10814.8 CDK99119.1 - 0.043 14.0 1.8 0.044 13.9 1.8 1.0 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA AAA_24 PF13479.6 CDK99121.1 - 1.2e-07 31.7 0.0 1.4e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain HTH_17 PF12728.7 CDK99122.1 - 3.2e-05 24.0 0.4 4.1e-05 23.7 0.4 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain MerR_1 PF13411.6 CDK99122.1 - 0.072 13.2 0.1 0.095 12.8 0.1 1.2 1 0 0 1 1 1 0 MerR HTH family regulatory protein SNase PF00565.17 CDK99130.1 - 1.1e-09 38.8 0.0 1.3e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Ribosomal_S20p PF01649.18 CDK99132.1 - 0.0043 17.7 0.7 0.1 13.2 1.2 2.0 1 1 1 2 2 2 1 Ribosomal protein S20 DUF1525 PF07511.11 CDK99132.1 - 0.037 14.2 3.7 0.043 13.9 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) KELK PF15796.5 CDK99132.1 - 0.049 14.1 0.2 0.061 13.8 0.2 1.3 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Cas_Cas1 PF01867.16 CDK99132.1 - 0.051 12.7 0.5 0.051 12.7 0.5 1.1 1 0 0 1 1 1 0 CRISPR associated protein Cas1 Vps5 PF09325.10 CDK99132.1 - 0.051 13.1 0.1 0.053 13.1 0.1 1.1 1 0 0 1 1 1 0 Vps5 C terminal like Zeta_toxin PF06414.12 CDK99138.1 - 5.5e-08 32.3 0.0 2.4e-07 30.2 0.0 1.9 1 1 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 CDK99138.1 - 8e-08 32.5 0.1 1.8e-07 31.4 0.0 1.6 1 1 1 2 2 2 1 AAA domain ABC_tran PF00005.27 CDK99138.1 - 0.002 18.7 0.1 0.0055 17.2 0.0 1.7 2 1 0 2 2 2 1 ABC transporter AAA_25 PF13481.6 CDK99138.1 - 0.0088 15.6 0.3 1.2 8.6 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 CDK99138.1 - 0.014 15.9 0.0 0.025 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDK99138.1 - 0.045 13.5 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 CDK99138.1 - 0.068 12.2 0.0 0.2 10.7 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_21 PF13304.6 CDK99138.1 - 0.07 12.9 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system cobW PF02492.19 CDK99138.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 CDK99138.1 - 0.13 12.2 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDK99138.1 - 0.15 12.0 0.2 0.35 10.8 0.1 1.7 2 0 0 2 2 2 0 NACHT domain SMC_N PF02463.19 CDK99138.1 - 0.2 11.1 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Resolvase PF00239.21 CDK99139.1 - 7.9e-22 77.9 0.6 1.8e-21 76.8 0.0 1.9 2 0 0 2 2 2 1 Resolvase, N terminal domain Recombinase PF07508.13 CDK99139.1 - 2.4e-18 66.4 0.0 4.7e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 Recombinase Zn_ribbon_recom PF13408.6 CDK99139.1 - 0.11 13.0 2.1 0.27 11.8 2.1 1.6 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Peptidase_S24 PF00717.23 CDK99140.1 - 9.7e-15 54.3 0.0 1.4e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase S24-like IMS PF00817.20 CDK99141.1 - 8.2e-35 120.0 0.0 2.3e-34 118.6 0.0 1.7 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 CDK99141.1 - 3.9e-06 27.6 0.0 9.9e-06 26.3 0.0 1.7 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CDK99141.1 - 0.013 15.8 0.0 0.03 14.6 0.0 1.6 1 0 0 1 1 1 0 IMS family HHH motif HlyD_3 PF13437.6 CDK99142.1 - 2.9e-09 37.6 0.0 1.5e-06 28.9 0.0 2.6 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDK99142.1 - 4.7e-08 32.7 0.0 1.3e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like HlyD_D23 PF16576.5 CDK99142.1 - 7.6e-07 28.6 0.0 1.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Peptidase_M50 PF02163.22 CDK99142.1 - 0.00013 21.3 4.4 0.0049 16.2 1.2 2.8 1 1 1 2 2 2 2 Peptidase family M50 HlyD_3 PF13437.6 CDK99144.1 - 4.5e-18 65.9 2.3 6.7e-12 46.1 0.0 2.4 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CDK99144.1 - 1.9e-06 27.2 0.2 3e-06 26.6 0.2 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK99144.1 - 2.2e-05 24.2 0.3 6.7e-05 22.6 0.3 1.9 1 0 0 1 1 1 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK99144.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 Biotin-requiring enzyme HlyD_3 PF13437.6 CDK99145.1 - 1.2e-15 58.1 0.6 7.3e-15 55.6 0.1 2.1 2 0 0 2 2 2 1 HlyD family secretion protein HlyD_D23 PF16576.5 CDK99145.1 - 6.6e-14 51.6 0.7 1.1e-13 51.0 0.7 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK99145.1 - 3.4e-08 33.2 0.6 0.012 15.4 0.0 2.9 3 0 0 3 3 3 2 Biotin-lipoyl like PTS_EIIA_1 PF00358.20 CDK99145.1 - 0.0065 16.2 0.0 1.3 8.8 0.0 2.5 2 0 0 2 2 2 2 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Biotin_lipoyl PF00364.22 CDK99145.1 - 0.0069 16.2 0.0 4.1 7.3 0.0 2.6 2 0 0 2 2 2 2 Biotin-requiring enzyme OEP PF02321.18 CDK99146.1 - 2.4e-28 99.2 20.7 1.3e-15 57.8 8.4 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein He_PIG PF05345.12 CDK99147.1 - 0.00015 21.9 0.0 0.00039 20.6 0.0 1.7 1 0 0 1 1 1 1 Putative Ig domain DUF4347 PF14252.6 CDK99148.1 - 3.3e-29 101.9 3.3 5e-29 101.2 3.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) PQQ PF01011.21 CDK99148.1 - 1.5e-07 31.0 15.7 3.4 7.7 0.1 7.8 7 0 0 7 7 7 4 PQQ enzyme repeat PQQ_3 PF13570.6 CDK99148.1 - 2.6e-07 30.9 25.2 3.6 8.2 0.1 9.2 8 1 1 9 9 9 5 PQQ-like domain HepII_C PF18675.1 CDK99148.1 - 0.00034 20.6 13.2 18 5.5 0.0 8.1 8 0 0 8 8 8 1 Heparinase II C-terminal domain A_amylase_inhib PF01356.19 CDK99148.1 - 0.079 13.0 0.6 7.9 6.6 0.0 3.5 3 0 0 3 3 3 0 Alpha amylase inhibitor BNR_4 PF15892.5 CDK99148.1 - 0.36 10.1 2.8 12 5.2 0.0 4.0 2 1 1 4 4 4 0 BNR repeat-containing family member 7TMR-DISMED2 PF07696.11 CDK99149.1 - 2.8e-30 105.1 0.0 7e-30 103.8 0.0 1.6 2 0 0 2 2 2 1 7TMR-DISM extracellular 2 7TMR-DISM_7TM PF07695.11 CDK99149.1 - 3.7e-26 92.3 23.1 6.4e-26 91.5 23.1 1.4 1 0 0 1 1 1 1 7TM diverse intracellular signalling HATPase_c PF02518.26 CDK99149.1 - 1.3e-15 57.8 0.0 2.2e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK99149.1 - 0.017 15.1 0.1 0.04 14.0 0.1 1.6 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 CDK99150.1 - 3.7e-21 75.4 0.0 5.4e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK99150.1 - 3.2e-17 62.4 0.1 3.9e-16 58.9 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal TonB_dep_Rec PF00593.24 CDK99151.1 - 3.6e-18 66.7 1.3 6.6e-18 65.8 1.4 1.3 1 1 0 1 1 1 1 TonB dependent receptor OMP_b-brl_3 PF14905.6 CDK99151.1 - 0.14 11.1 0.0 2 7.3 0.0 2.6 3 0 0 3 3 3 0 Outer membrane protein beta-barrel family Relaxase PF03432.14 CDK99153.1 - 7.4e-32 110.9 0.1 1.2e-31 110.2 0.1 1.3 1 0 0 1 1 1 1 Relaxase/Mobilisation nuclease domain CW_binding_2 PF04122.12 CDK99153.1 - 0.062 14.0 0.1 0.4 11.4 0.1 2.4 2 1 0 2 2 2 0 Putative cell wall binding repeat 2 MobL PF18555.1 CDK99153.1 - 2.5 7.3 4.7 3 7.0 2.4 1.8 1 1 1 2 2 2 0 MobL relaxases NNMT_PNMT_TEMT PF01234.17 CDK99154.1 - 0.021 14.0 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family DUF3618 PF12277.8 CDK99154.1 - 0.032 14.5 0.1 0.15 12.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3618) CopC PF04234.12 CDK99154.1 - 0.056 14.5 0.0 0.082 14.0 0.0 1.3 1 1 0 1 1 1 0 CopC domain WXG100 PF06013.12 CDK99154.1 - 0.069 13.4 0.2 5.1 7.4 0.1 2.4 2 0 0 2 2 2 0 Proteins of 100 residues with WXG TGT_C2 PF14810.6 CDK99154.1 - 0.09 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Patch-forming domain C2 of tRNA-guanine transglycosylase Tudor_4 PF18358.1 CDK99154.1 - 0.13 11.8 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain MPTase-PolyVal PF18818.1 CDK99155.1 - 1.1e-42 145.0 0.5 2.5e-42 143.9 0.2 1.7 2 0 0 2 2 2 1 Metallopeptidase superfamily domain DUF1738 PF08401.11 CDK99155.1 - 2.9e-29 101.8 0.2 5.7e-29 100.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1738) Toprim_3 PF13362.6 CDK99155.1 - 1e-11 45.0 0.1 1e-11 45.0 0.1 2.3 2 0 0 2 2 2 1 Toprim domain Toprim_4 PF13662.6 CDK99155.1 - 0.0021 18.5 0.1 0.0048 17.3 0.1 1.6 1 0 0 1 1 1 1 Toprim domain SSB PF00436.25 CDK99157.1 - 2.4e-40 136.8 0.1 4.4e-21 74.9 0.0 2.0 2 0 0 2 2 2 2 Single-strand binding protein family T4SS-DNA_transf PF02534.14 CDK99158.1 - 4.1e-103 345.7 0.0 5.2e-103 345.4 0.0 1.0 1 0 0 1 1 1 1 Type IV secretory system Conjugative DNA transfer TraG-D_C PF12696.7 CDK99158.1 - 1.2e-32 112.5 0.0 2.4e-32 111.6 0.0 1.5 1 0 0 1 1 1 1 TraM recognition site of TraD and TraG TrwB_AAD_bind PF10412.9 CDK99158.1 - 1.7e-20 73.3 0.0 1.4e-19 70.3 0.0 2.0 1 1 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 CDK99159.1 - 1.5e-28 99.6 0.0 1.8e-28 99.4 0.0 1.0 1 0 0 1 1 1 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 CDK99159.1 - 0.0026 17.2 0.0 0.0081 15.5 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_16 PF13191.6 CDK99159.1 - 0.0031 17.9 0.0 0.0058 17.0 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 CDK99159.1 - 0.0078 16.3 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 CDK99159.1 - 0.018 15.3 0.0 0.072 13.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CDK99159.1 - 0.036 13.6 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 CDK99159.1 - 0.047 13.4 0.0 3 7.7 0.0 2.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain SH3_4 PF06347.13 CDK99159.1 - 0.063 13.1 0.0 0.2 11.5 0.0 1.8 1 0 0 1 1 1 0 Bacterial SH3 domain AAA_24 PF13479.6 CDK99159.1 - 0.073 12.8 0.0 0.25 11.0 0.0 1.9 1 1 1 2 2 2 0 AAA domain Septin PF00735.18 CDK99159.1 - 0.1 11.9 0.0 0.2 10.9 0.0 1.4 2 0 0 2 2 2 0 Septin MobB PF03205.14 CDK99159.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Mg_chelatase PF01078.21 CDK99159.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TrbI PF03743.14 CDK99161.1 - 6.6e-37 127.2 3.1 9e-37 126.7 3.1 1.1 1 0 0 1 1 1 1 Bacterial conjugation TrbI-like protein DUF515 PF04415.12 CDK99161.1 - 4.6 5.5 4.6 6.3 5.1 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) CagX PF03524.15 CDK99162.1 - 5.7e-26 91.6 0.0 8e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 Conjugal transfer protein Totivirus_coat PF05518.11 CDK99162.1 - 4 5.4 7.5 6.3 4.7 7.5 1.2 1 0 0 1 1 1 0 Totivirus coat protein VirB8 PF04335.13 CDK99163.1 - 1.1e-14 54.8 0.2 1.4e-14 54.5 0.2 1.1 1 0 0 1 1 1 1 VirB8 protein TrbL PF04610.14 CDK99165.1 - 0.0024 17.7 24.8 0.0024 17.7 24.8 2.5 1 1 0 2 2 2 1 TrbL/VirB6 plasmid conjugal transfer protein Git3 PF11710.8 CDK99165.1 - 1.1 9.0 9.4 1.6 8.5 4.0 2.4 1 1 1 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 GYF PF02213.16 CDK99166.1 - 0.065 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 GYF domain TraF_2 PF13729.6 CDK99167.1 - 0.035 13.5 1.8 0.068 12.5 1.8 1.4 1 0 0 1 1 1 0 F plasmid transfer operon, TraF, protein T4SS PF07996.11 CDK99167.1 - 0.037 14.4 20.6 0.6 10.5 20.6 2.5 1 1 0 1 1 1 0 Type IV secretion system proteins DASH_Dam1 PF08653.10 CDK99167.1 - 0.17 11.7 1.0 4.6 7.1 0.2 2.6 2 0 0 2 2 2 0 DASH complex subunit Dam1 Calpain_inhib PF00748.19 CDK99167.1 - 0.21 12.1 2.2 0.37 11.3 2.2 1.4 1 0 0 1 1 1 0 Calpain inhibitor DUF3535 PF12054.8 CDK99167.1 - 0.25 10.6 7.9 0.072 12.3 5.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3535) NPV_P10 PF05531.12 CDK99167.1 - 1.5 9.3 9.3 2.2 8.8 0.5 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein BH3 PF15285.6 CDK99168.1 - 0.013 15.2 0.4 0.038 13.8 0.0 2.0 2 0 0 2 2 2 0 Beclin-1 BH3 domain, Bcl-2-interacting AAA_16 PF13191.6 CDK99168.1 - 0.052 13.9 0.1 0.45 10.9 0.2 2.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.6 CDK99168.1 - 0.067 13.5 0.5 0.84 10.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CDK99168.1 - 0.14 12.1 0.0 17 5.3 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea CoatB PF10389.9 CDK99169.1 - 6.2 6.7 11.8 30 4.6 11.8 2.0 1 1 1 2 2 2 0 Bacteriophage coat protein B TrbC PF04956.13 CDK99170.1 - 0.0001 22.4 7.4 0.00016 21.8 7.4 1.4 1 1 0 1 1 1 1 TrbC/VIRB2 family DUF4231 PF14015.6 CDK99170.1 - 0.0041 17.6 1.3 0.0052 17.2 1.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF4231) DUF2254 PF10011.9 CDK99170.1 - 1.3 7.7 3.9 0.71 8.6 2.2 1.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2254) Yip1 PF04893.17 CDK99170.1 - 6.4 6.5 15.1 15 5.3 15.2 1.6 1 1 0 1 1 1 0 Yip1 domain Activator-TraM PF11657.8 CDK99171.1 - 0.00011 22.1 1.5 0.0024 17.7 1.5 2.1 1 1 0 1 1 1 1 Transcriptional activator TraM HAD PF12710.7 CDK99171.1 - 0.006 17.0 0.1 0.0091 16.4 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Endotoxin_C2 PF18449.1 CDK99171.1 - 0.007 16.7 0.1 0.012 15.9 0.1 1.3 1 0 0 1 1 1 1 Delta endotoxin TSKS PF15358.6 CDK99171.1 - 0.0072 14.8 0.1 0.009 14.4 0.1 1.1 1 0 0 1 1 1 1 Testis-specific serine kinase substrate CbiA PF01656.23 CDK99172.1 - 1.9e-05 24.7 0.0 2.1e-05 24.6 0.0 1.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CDK99172.1 - 0.00011 21.5 0.0 0.00021 20.6 0.0 1.4 1 0 0 1 1 1 1 Anion-transporting ATPase ParA PF10609.9 CDK99172.1 - 0.00016 21.2 0.0 0.00021 20.9 0.0 1.2 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_31 PF13614.6 CDK99172.1 - 0.001 19.0 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain NTP_transf_2 PF01909.23 CDK99175.1 - 2.1e-08 34.3 0.0 3.3e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 CDK99175.1 - 3.5e-07 30.2 0.0 5.6e-07 29.6 0.0 1.4 1 1 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase ABM PF03992.16 CDK99175.1 - 0.079 13.1 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase HEPN PF05168.14 CDK99176.1 - 5.4e-15 55.6 0.0 6.3e-15 55.4 0.0 1.0 1 0 0 1 1 1 1 HEPN domain SNF2_N PF00176.23 CDK99177.1 - 9.6e-51 172.5 0.0 1.8e-50 171.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3670 PF12419.8 CDK99177.1 - 2.6e-30 105.1 0.8 8.9e-30 103.3 0.3 2.1 2 0 0 2 2 2 1 SNF2 Helicase protein Helicase_C PF00271.31 CDK99177.1 - 1e-15 58.0 0.0 3.3e-15 56.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDK99177.1 - 0.00047 20.0 0.0 0.0014 18.4 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CDK99177.1 - 0.071 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CDK99177.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase SWIM PF04434.17 CDK99178.1 - 0.0024 17.5 0.2 0.0051 16.4 0.2 1.5 1 0 0 1 1 1 1 SWIM zinc finger Phage_integrase PF00589.22 CDK99179.1 - 1.2e-18 67.5 0.0 2.3e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family Arm-DNA-bind_3 PF13356.6 CDK99179.1 - 3.1e-14 53.1 0.1 6.4e-14 52.1 0.1 1.6 1 0 0 1 1 1 1 Arm DNA-binding domain Phage_int_SAM_3 PF14659.6 CDK99179.1 - 0.00014 22.1 0.0 0.00024 21.3 0.0 1.4 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain HTH_17 PF12728.7 CDK99180.1 - 7.6e-17 61.2 0.0 9.8e-17 60.9 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDK99180.1 - 7.3e-05 22.5 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_22 PF13309.6 CDK99180.1 - 0.00044 20.3 0.0 0.00075 19.5 0.0 1.4 1 0 0 1 1 1 1 HTH domain HTH_28 PF13518.6 CDK99180.1 - 0.00054 20.0 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_36 PF13730.6 CDK99180.1 - 0.00075 19.4 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.12 CDK99180.1 - 0.00079 19.3 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 HTH domain HTH_29 PF13551.6 CDK99180.1 - 0.00082 19.4 0.1 0.0022 18.0 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix Phage_CI_repr PF07022.13 CDK99180.1 - 0.00097 19.2 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain YdaS_antitoxin PF15943.5 CDK99180.1 - 0.0016 18.3 0.0 0.0027 17.5 0.0 1.5 1 1 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Sigma70_r4_2 PF08281.12 CDK99180.1 - 0.0019 17.8 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 Terminase_5 PF06056.12 CDK99180.1 - 0.0025 17.7 0.0 0.0055 16.6 0.0 1.5 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) HTH_Tnp_1_2 PF13022.6 CDK99180.1 - 0.0039 17.3 0.0 0.0049 17.0 0.0 1.3 1 1 0 1 1 1 1 Helix-turn-helix of insertion element transposase DUF1323 PF07037.11 CDK99180.1 - 0.0046 17.3 0.1 0.0074 16.7 0.1 1.4 1 1 0 1 1 1 1 Putative transcription regulator (DUF1323) HTH_Tnp_ISL3 PF13542.6 CDK99180.1 - 0.0049 16.2 0.0 0.0076 15.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_DeoR PF08220.12 CDK99180.1 - 0.0063 16.2 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain TetR_N PF00440.23 CDK99180.1 - 0.0066 16.2 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_10 PF04967.12 CDK99180.1 - 0.0076 16.0 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 HTH DNA binding domain Phage_AlpA PF05930.12 CDK99180.1 - 0.017 14.9 0.1 0.035 13.9 0.1 1.6 1 1 0 1 1 1 0 Prophage CP4-57 regulatory protein (AlpA) HTH_Tnp_IS630 PF01710.16 CDK99180.1 - 0.018 15.1 0.1 0.021 14.9 0.1 1.1 1 0 0 1 1 1 0 Transposase P22_Cro PF14549.6 CDK99180.1 - 0.025 14.4 0.0 0.037 13.9 0.0 1.2 1 0 0 1 1 1 0 DNA-binding transcriptional regulator Cro HTH_3 PF01381.22 CDK99180.1 - 0.031 14.4 0.0 0.046 13.8 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix CENP-B_N PF04218.13 CDK99180.1 - 0.037 13.6 0.0 0.063 12.9 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Phage_terminase PF10668.9 CDK99180.1 - 0.039 14.0 3.3 0.061 13.3 0.1 2.2 1 1 1 2 2 2 0 Phage terminase small subunit HTH_Tnp_1 PF01527.20 CDK99180.1 - 0.04 14.2 0.2 0.09 13.1 0.2 1.8 1 1 0 1 1 1 0 Transposase HTH_40 PF14493.6 CDK99180.1 - 0.13 12.7 0.0 0.13 12.7 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.7 CDK99180.1 - 0.19 11.6 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 MarR family UPF0122 PF04297.14 CDK99180.1 - 0.2 11.9 0.0 0.26 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like DNA_methylase PF00145.17 CDK99181.1 - 1.7e-49 169.0 0.0 2.3e-49 168.5 0.0 1.2 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Methyltransf_15 PF09445.10 CDK99181.1 - 0.22 11.1 0.0 0.38 10.3 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DUF4143 PF13635.6 CDK99182.1 - 1.8e-19 70.1 0.0 3.3e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4143) SNF2_N PF00176.23 CDK99182.1 - 3e-10 39.4 0.0 1.1e-09 37.4 0.0 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 CDK99182.1 - 4.5e-06 26.8 0.0 9.6e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDK99182.1 - 0.0024 17.7 0.0 0.57 9.9 0.0 2.2 2 0 0 2 2 2 2 DEAD/DEAH box helicase AAA_22 PF13401.6 CDK99182.1 - 0.007 16.6 0.0 0.03 14.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain DUF3173 PF11372.8 CDK99182.1 - 0.059 13.2 0.0 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3173) AAA_34 PF13872.6 CDK99182.1 - 0.093 11.6 0.0 0.22 10.4 0.0 1.6 2 0 0 2 2 2 0 P-loop containing NTP hydrolase pore-1 EAL PF00563.20 CDK99183.1 - 2.9e-76 256.1 0.2 5.6e-76 255.2 0.2 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK99183.1 - 3.1e-53 179.8 0.1 5.8e-53 178.9 0.1 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDK99183.1 - 1.2e-18 67.2 0.0 4.3e-14 52.6 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 CDK99183.1 - 4.3e-14 52.7 0.1 2.2e-08 34.3 0.0 3.4 4 0 0 4 4 3 2 PAS fold PAS PF00989.25 CDK99183.1 - 4.9e-14 52.3 0.0 6.9e-13 48.6 0.0 2.8 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 CDK99183.1 - 9.1e-08 32.3 0.0 4.1e-06 27.0 0.0 2.8 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDK99183.1 - 2.9e-06 27.2 0.0 8.2e-05 22.5 0.0 2.9 2 0 0 2 2 2 1 PAS domain YpmT PF17431.2 CDK99183.1 - 0.0037 17.3 0.2 0.0083 16.1 0.2 1.5 1 0 0 1 1 1 1 Uncharacterized YmpT-like DUF948 PF06103.11 CDK99183.1 - 0.011 16.0 0.8 0.041 14.1 0.1 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4064 PF13273.6 CDK99183.1 - 0.031 14.5 0.1 2.8 8.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) PAS_12 PF18095.1 CDK99183.1 - 0.089 12.4 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain Baculo_11_kDa PF06143.11 CDK99183.1 - 0.15 11.7 1.5 0.5 10.0 0.6 2.3 2 0 0 2 2 2 0 Baculovirus 11 kDa family Orf78 PF06024.12 CDK99183.1 - 0.17 12.2 1.5 0.43 10.9 1.5 1.6 1 0 0 1 1 1 0 Orf78 (ac78) Phage_integrase PF00589.22 CDK99185.1 - 1.6e-20 73.6 0.0 3.6e-20 72.5 0.0 1.6 2 0 0 2 2 2 1 Phage integrase family Phage_int_SAM_5 PF13102.6 CDK99185.1 - 0.034 14.5 0.0 0.079 13.3 0.0 1.6 1 0 0 1 1 1 0 Phage integrase SAM-like domain Phage_int_SAM_1 PF02899.17 CDK99185.1 - 0.052 13.8 0.2 0.14 12.5 0.2 1.8 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Mg-por_mtran_C PF07109.11 CDK99185.1 - 0.12 12.8 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Magnesium-protoporphyrin IX methyltransferase C-terminus D5_N PF08706.11 CDK99188.1 - 1.4e-08 35.2 0.0 3.6e-08 33.8 0.0 1.8 1 1 0 1 1 1 1 D5 N terminal like Pox_D5 PF03288.16 CDK99188.1 - 0.00017 22.0 0.0 0.00047 20.6 0.0 1.7 2 0 0 2 2 2 1 Poxvirus D5 protein-like Parvo_NS1 PF01057.17 CDK99188.1 - 0.061 12.4 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 YmdB PF13277.6 CDK99188.1 - 0.13 11.6 0.1 0.23 10.8 0.1 1.3 1 0 0 1 1 1 0 YmdB-like protein MarR_2 PF12802.7 CDK99189.1 - 0.0042 16.9 0.2 2 8.4 0.0 2.4 2 0 0 2 2 2 2 MarR family KORA PF16509.5 CDK99189.1 - 0.017 15.4 0.0 0.073 13.4 0.0 2.0 2 0 0 2 2 2 0 TrfB plasmid transcriptional repressor Terminase_GpA PF05876.12 CDK99190.1 - 1.2e-195 651.3 0.0 1.6e-195 650.9 0.0 1.0 1 0 0 1 1 1 1 Phage terminase large subunit (GpA) KAAG1 PF15354.6 CDK99190.1 - 0.055 14.0 0.1 0.24 12.0 0.0 2.2 1 1 0 1 1 1 0 Kidney-associated antigen 1 SHR3_chaperone PF08229.11 CDK99190.1 - 0.1 11.6 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 ER membrane protein SH3 ShlB PF03865.13 CDK99192.1 - 4.1e-25 88.9 8.3 6.2e-25 88.3 8.3 1.3 1 0 0 1 1 1 1 Haemolysin secretion/activation protein ShlB/FhaC/HecB POTRA_2 PF08479.11 CDK99192.1 - 6.2e-19 67.6 0.0 1.1e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 POTRA domain, ShlB-type Haemagg_act PF05860.13 CDK99193.1 - 5.2e-23 81.2 5.9 5.2e-23 81.2 5.9 2.7 2 0 0 2 2 2 1 haemagglutination activity domain Peptidase_M26_N PF05342.14 CDK99193.1 - 2e-07 30.7 0.2 3.5e-07 29.9 0.2 1.3 1 0 0 1 1 1 1 M26 IgA1-specific Metallo-endopeptidase N-terminal region FliJ PF02050.16 CDK99193.1 - 0.072 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Flagellar FliJ protein Trypan_PARP PF05887.11 CDK99193.1 - 0.096 12.7 3.6 0.22 11.5 3.6 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Phage_portal_2 PF05136.13 CDK99194.1 - 9.6e-101 337.5 0.0 1.4e-100 337.0 0.0 1.2 1 0 0 1 1 1 1 Phage portal protein, lambda family DUF883 PF05957.13 CDK99194.1 - 5.6 7.7 6.4 3.2 8.4 0.8 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Mu-like_gpT PF10124.9 CDK99195.1 - 8.9e-14 51.5 0.0 3.4e-06 26.6 0.0 2.1 1 1 1 2 2 2 2 Mu-like prophage major head subunit gpT Peptidase_S78 PF04586.17 CDK99195.1 - 0.00032 20.9 0.0 0.00056 20.1 0.0 1.3 1 0 0 1 1 1 1 Caudovirus prohead serine protease STAS_2 PF13466.6 CDK99196.1 - 0.00083 19.6 0.8 0.001 19.4 0.8 1.1 1 0 0 1 1 1 1 STAS domain gpW PF02831.15 CDK99196.1 - 0.067 13.1 0.1 0.077 12.9 0.1 1.3 1 0 0 1 1 1 0 gpW DUF2190 PF09956.9 CDK99197.1 - 3.3e-21 75.7 5.6 3.9e-21 75.5 5.6 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2190) SPOR PF05036.13 CDK99201.1 - 2.8e-11 43.6 0.1 1.3e-10 41.5 0.0 2.2 2 0 0 2 2 2 1 Sporulation related domain TPR_16 PF13432.6 CDK99201.1 - 6.7e-08 33.1 0.4 6.7e-08 33.1 0.4 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat SHOCT PF09851.9 CDK99201.1 - 9e-07 28.4 1.2 1.6e-05 24.4 0.2 3.0 3 0 0 3 3 3 1 Short C-terminal domain TPR_2 PF07719.17 CDK99201.1 - 2.4e-06 27.2 2.0 0.1 12.7 0.6 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDK99201.1 - 0.00023 21.1 0.6 0.078 13.2 0.3 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDK99201.1 - 0.0004 20.1 1.4 0.23 11.3 1.4 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDK99201.1 - 0.00059 20.3 2.6 0.36 11.6 0.5 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDK99201.1 - 0.0083 16.2 0.4 0.034 14.3 0.4 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat HemY_N PF07219.13 CDK99201.1 - 0.016 15.4 0.6 0.064 13.5 0.2 2.3 2 0 0 2 2 1 0 HemY protein N-terminus CtsR_C PF17727.1 CDK99201.1 - 0.06 13.5 0.1 2 8.6 0.0 2.5 2 0 0 2 2 2 0 CtsR C-terminal dimerization domain TPR_12 PF13424.6 CDK99201.1 - 0.087 13.1 5.2 0.84 10.0 4.3 2.8 2 1 0 2 2 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDK99201.1 - 0.12 12.4 2.5 1.8 8.8 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDK99201.1 - 0.13 12.1 2.9 2.7 8.0 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDK99201.1 - 0.27 11.4 0.9 31 4.7 0.2 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat VbhA PF18495.1 CDK99201.1 - 2.4 8.1 6.3 48 3.9 0.1 3.9 4 0 0 4 4 4 0 Antitoxin VbhA CHAD PF05235.14 CDK99202.1 - 9.8e-58 195.8 3.7 1.7e-57 195.0 3.7 1.4 1 0 0 1 1 1 1 CHAD domain CYTH PF01928.21 CDK99202.1 - 1.4e-20 74.0 0.0 3e-20 72.9 0.0 1.6 2 0 0 2 2 2 1 CYTH domain Exotox-A_target PF09102.10 CDK99202.1 - 0.15 12.0 0.4 0.39 10.7 0.0 1.9 2 0 0 2 2 2 0 Exotoxin A, targeting DUF4169 PF13770.6 CDK99203.1 - 3.6e-21 75.2 15.4 4e-21 75.0 15.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4169) Ammonium_transp PF00909.21 CDK99205.1 - 1.2e-85 287.7 31.6 1.3e-85 287.5 31.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family HATPase_c PF02518.26 CDK99206.1 - 6.8e-25 87.7 0.0 1.5e-24 86.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK99206.1 - 2.6e-11 43.4 0.9 1.4e-10 41.1 0.1 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 CDK99206.1 - 1.5e-07 31.6 0.0 3.2e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDK99206.1 - 4.8e-05 23.6 0.0 0.00012 22.2 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CDK99206.1 - 0.0015 18.5 0.0 0.0051 16.8 0.0 2.0 1 1 0 1 1 1 1 PAS fold dCache_1 PF02743.18 CDK99206.1 - 0.0042 16.9 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Cache domain PAS_8 PF13188.7 CDK99206.1 - 0.0085 16.1 0.0 0.039 14.0 0.0 2.1 1 0 0 1 1 1 1 PAS domain HATPase_c_5 PF14501.6 CDK99206.1 - 0.017 15.0 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 GHKL domain HATPase_c_3 PF13589.6 CDK99206.1 - 0.045 13.6 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_12 PF18095.1 CDK99206.1 - 0.071 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain Abhydrolase_6 PF12697.7 CDK99207.1 - 4.3e-14 53.7 10.3 5.2e-14 53.4 10.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDK99207.1 - 1.7e-11 44.2 0.3 6.1e-07 29.3 0.2 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDK99207.1 - 4.1e-07 29.5 0.0 0.0061 15.9 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF1057 PF06342.12 CDK99207.1 - 0.00032 19.8 0.0 0.00041 19.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Ndr PF03096.14 CDK99207.1 - 0.0028 16.4 0.0 0.31 9.7 0.0 2.1 2 0 0 2 2 2 2 Ndr family Abhydrolase_3 PF07859.13 CDK99207.1 - 0.0069 16.3 0.0 0.0089 15.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CDK99207.1 - 0.035 13.9 0.0 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 CDK99207.1 - 0.15 11.5 0.0 4 6.8 0.0 2.1 1 1 0 1 1 1 0 Prolyl oligopeptidase family SNase PF00565.17 CDK99207.1 - 0.19 12.2 0.0 0.3 11.6 0.0 1.2 1 0 0 1 1 1 0 Staphylococcal nuclease homologue MarR_2 PF12802.7 CDK99208.1 - 7.6e-10 38.5 1.5 1.4e-09 37.7 1.5 1.5 1 0 0 1 1 1 1 MarR family MarR PF01047.22 CDK99208.1 - 2.6e-08 33.7 0.3 5.5e-08 32.6 0.1 1.7 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 CDK99208.1 - 6.8e-06 26.5 0.1 1.1e-05 25.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.19 CDK99208.1 - 0.00088 19.1 0.0 0.032 14.1 0.0 2.3 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 CDK99208.1 - 0.003 17.3 1.4 0.0056 16.4 0.7 1.8 2 0 0 2 2 2 1 IclR helix-turn-helix domain TFIIE_alpha PF02002.17 CDK99208.1 - 0.058 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 TFIIE alpha subunit FAA_hydrolase PF01557.18 CDK99209.1 - 1.5e-46 158.8 0.0 1.8e-46 158.6 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Herpes_UL36 PF03586.13 CDK99210.1 - 0.12 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL36 tegument protein DUF2997 PF11211.8 CDK99210.1 - 0.15 11.9 0.1 0.26 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) Abhydrolase_1 PF00561.20 CDK99211.1 - 5.6e-14 52.4 0.0 2.5e-07 30.6 0.0 2.7 2 1 1 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDK99211.1 - 2.4e-11 44.6 6.4 2.9e-11 44.4 6.4 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDK99211.1 - 1.1e-08 34.7 0.0 2.2e-07 30.4 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CDK99211.1 - 1.3e-07 32.0 0.0 3e-07 30.8 0.0 1.6 1 1 0 1 1 1 1 Thioesterase domain Ser_hydrolase PF06821.13 CDK99211.1 - 7.2e-06 26.0 0.0 0.007 16.2 0.0 2.2 1 1 1 2 2 2 2 Serine hydrolase Abhydrolase_4 PF08386.10 CDK99211.1 - 1.5e-05 25.0 0.0 2.7e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Esterase PF00756.20 CDK99211.1 - 4.6e-05 23.2 0.0 5.6e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.14 CDK99211.1 - 0.00075 18.3 0.0 0.00082 18.2 0.0 1.3 1 1 0 1 1 1 1 Ndr family Abhydrolase_5 PF12695.7 CDK99211.1 - 0.0063 16.3 0.0 0.14 12.0 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family FSH1 PF03959.13 CDK99211.1 - 0.0093 15.7 0.0 0.016 14.8 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) LIDHydrolase PF10230.9 CDK99211.1 - 0.015 14.9 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF2048 PF09752.9 CDK99211.1 - 0.027 13.6 0.0 1.6 7.8 0.0 2.1 2 0 0 2 2 2 0 Abhydrolase domain containing 18 UPF0227 PF05728.12 CDK99211.1 - 0.17 11.8 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Isochorismatase PF00857.20 CDK99212.1 - 2.4e-27 96.3 0.1 2.8e-27 96.0 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family DEAD PF00270.29 CDK99213.1 - 1.5e-52 177.9 0.0 2.4e-52 177.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDK99213.1 - 3.9e-29 101.2 0.1 2.2e-28 98.8 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDK99213.1 - 1.8e-07 31.3 0.0 3.7e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PRAI PF00697.22 CDK99213.1 - 0.087 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase AAA_22 PF13401.6 CDK99213.1 - 0.24 11.7 1.3 1.6 9.0 1.1 2.3 1 1 0 1 1 1 0 AAA domain AsnC_trans_reg PF01037.21 CDK99214.1 - 5.1e-14 52.0 0.1 5.7e-14 51.8 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain Cytochrom_NNT PF03264.14 CDK99215.1 - 9.1e-77 256.6 2.7 1.1e-76 256.4 2.7 1.1 1 0 0 1 1 1 1 NapC/NirT cytochrome c family, N-terminal region Cytochrome_C7 PF14522.6 CDK99215.1 - 7.8e-08 32.2 12.1 1.3e-05 25.0 2.0 2.8 2 1 1 3 3 3 3 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 CDK99215.1 - 3.3e-07 30.7 8.7 0.0014 19.0 3.4 2.3 2 0 0 2 2 2 2 Cytochrome c3 Cytochrom_CIII PF02085.16 CDK99215.1 - 4.9e-06 26.8 10.7 0.00072 19.9 2.1 2.5 2 1 0 2 2 2 2 Class III cytochrome C family Paired_CXXCH_1 PF09699.10 CDK99215.1 - 0.0048 16.6 13.7 0.22 11.3 2.9 3.5 2 2 0 2 2 2 2 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_C554 PF13435.6 CDK99215.1 - 0.035 15.0 14.6 1.5 9.8 9.6 3.1 1 1 3 4 4 4 0 Cytochrome c554 and c-prime zf-C4pol PF14260.6 CDK99215.1 - 0.037 14.5 5.3 2.9 8.4 1.0 2.7 2 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta zinc-ribbon_6 PF10005.9 CDK99215.1 - 0.39 11.4 6.4 4.2 8.1 0.2 3.1 2 1 1 3 3 3 0 zinc-ribbon domain Defensin_5 PF18251.1 CDK99215.1 - 0.8 9.8 8.9 34 4.6 0.0 4.0 4 0 0 4 4 4 0 Fungal defensin Copsin DHC PF09626.10 CDK99215.1 - 6.2 7.7 17.0 0.27 12.1 0.4 3.8 2 2 2 4 4 4 0 Dihaem cytochrome c Cytochrome_P460 PF16694.5 CDK99215.1 - 7.6 6.9 20.2 5.4 7.4 0.4 4.1 2 2 2 4 4 4 0 Cytochrome P460 NapB PF03892.14 CDK99216.1 - 1.5e-41 141.4 1.1 1.8e-41 141.1 1.1 1.0 1 0 0 1 1 1 1 Nitrate reductase cytochrome c-type subunit (NapB) Cytochrome_C7 PF14522.6 CDK99216.1 - 0.0033 17.4 0.6 0.0076 16.2 0.6 1.6 1 1 0 1 1 1 1 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 CDK99216.1 - 0.0065 16.9 0.3 0.012 16.0 0.3 1.5 1 0 0 1 1 1 1 Cytochrome c3 Paired_CXXCH_1 PF09699.10 CDK99216.1 - 0.0094 15.7 1.5 0.078 12.7 1.5 2.2 1 1 1 2 2 2 2 Doubled CXXCH motif (Paired_CXXCH_1) DUF3365 PF11845.8 CDK99216.1 - 0.01 16.1 0.8 0.13 12.6 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3365) Cytochrome_C554 PF13435.6 CDK99216.1 - 0.014 16.2 1.1 0.2 12.6 0.8 2.2 1 1 1 2 2 2 0 Cytochrome c554 and c-prime Cytochrom_NNT PF03264.14 CDK99216.1 - 0.02 14.6 0.7 0.02 14.6 0.7 1.9 2 1 1 3 3 3 0 NapC/NirT cytochrome c family, N-terminal region Cytochrome_CBB3 PF13442.6 CDK99216.1 - 0.064 13.6 0.2 13 6.2 0.0 2.5 1 1 1 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III Fer4_5 PF12801.7 CDK99217.1 - 3.6e-18 65.3 11.1 9.1e-14 51.2 2.6 3.5 4 0 0 4 4 4 2 4Fe-4S binding domain Fer4_9 PF13187.6 CDK99217.1 - 2.8e-07 30.6 9.3 0.00071 19.7 2.1 2.8 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK99217.1 - 1.3e-06 28.2 4.5 1.3e-06 28.2 4.5 3.6 4 0 0 4 4 4 2 4Fe-4S binding domain Fer4 PF00037.27 CDK99217.1 - 3.9e-06 26.5 22.8 0.026 14.3 3.0 4.2 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_7 PF12838.7 CDK99217.1 - 6.8e-06 26.6 14.7 0.00043 20.8 11.3 3.2 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDK99217.1 - 0.00017 22.5 11.7 0.17 12.9 0.4 3.8 4 0 0 4 4 4 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 CDK99217.1 - 0.00023 21.2 11.4 0.00023 21.2 11.4 2.5 3 1 0 3 3 3 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDK99217.1 - 0.00073 19.6 18.0 0.0012 19.0 10.2 3.1 2 1 0 3 3 3 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDK99217.1 - 0.0014 18.6 21.3 0.0093 16.0 4.3 3.2 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_8 PF13183.6 CDK99217.1 - 0.022 15.2 12.2 0.24 11.9 0.2 3.0 4 0 0 4 4 4 0 4Fe-4S dicluster domain Ni_hydr_CYTB PF01292.20 CDK99217.1 - 0.062 12.9 8.5 0.13 11.9 7.8 1.7 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Fer4_3 PF12798.7 CDK99217.1 - 0.33 12.0 28.3 0.49 11.4 4.3 4.2 4 0 0 4 4 4 0 4Fe-4S binding domain Fer4_7 PF12838.7 CDK99218.1 - 4e-13 49.7 24.3 6.9e-07 29.8 7.1 2.8 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK99218.1 - 6.4e-13 48.2 30.6 2.8e-05 24.0 2.0 4.4 4 0 0 4 4 4 4 4Fe-4S binding domain Fer4_10 PF13237.6 CDK99218.1 - 9.6e-12 44.8 16.3 0.0016 18.5 0.1 3.6 3 1 1 4 4 4 4 4Fe-4S dicluster domain Fer4 PF00037.27 CDK99218.1 - 4.5e-11 42.1 33.4 4.5e-05 23.1 3.2 4.9 5 0 0 5 5 5 4 4Fe-4S binding domain Fer4_2 PF12797.7 CDK99218.1 - 2.1e-08 33.7 34.1 0.00068 19.6 2.7 4.4 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_4 PF12800.7 CDK99218.1 - 2.6e-08 33.7 32.6 0.005 17.2 2.5 4.8 4 1 0 4 4 4 3 4Fe-4S binding domain Fer4_9 PF13187.6 CDK99218.1 - 3.4e-08 33.5 25.2 0.0018 18.4 9.5 3.5 1 1 3 4 4 4 4 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDK99218.1 - 4.6e-05 23.9 23.4 0.0044 17.5 0.2 3.8 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDK99218.1 - 5.8e-05 23.1 27.2 0.014 15.5 9.8 3.5 1 1 3 4 4 4 4 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDK99218.1 - 7.9e-05 23.5 28.4 0.16 12.9 0.7 4.1 2 1 1 3 3 3 3 4Fe-4S double cluster binding domain Fer4_3 PF12798.7 CDK99218.1 - 0.00019 22.1 40.4 0.069 14.1 5.3 4.5 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_8 PF13183.6 CDK99218.1 - 0.00041 20.7 26.5 0.032 14.7 8.6 3.6 2 2 2 4 4 4 3 4Fe-4S dicluster domain Fer4_22 PF17179.4 CDK99218.1 - 0.012 16.4 2.3 0.012 16.4 2.3 3.7 3 1 1 4 4 4 0 4Fe-4S dicluster domain Fer4_20 PF14691.6 CDK99218.1 - 8.5 6.2 19.1 2.3 8.0 4.5 3.2 2 1 1 3 3 3 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Molybdopterin PF00384.22 CDK99219.1 - 3.2e-89 299.8 0.2 4.3e-89 299.4 0.2 1.2 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 CDK99219.1 - 6.1e-25 87.4 0.0 1.5e-24 86.1 0.0 1.7 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain Molybdop_Fe4S4 PF04879.16 CDK99219.1 - 6.5e-19 67.7 0.9 1.6e-18 66.5 0.5 2.0 2 0 0 2 2 2 1 Molybdopterin oxidoreductase Fe4S4 domain TAT_signal PF10518.9 CDK99219.1 - 0.00025 20.7 3.1 0.00054 19.7 3.1 1.6 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence PSD3 PF07626.11 CDK99219.1 - 0.16 12.4 0.1 25 5.5 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1587) NapD PF03927.13 CDK99220.1 - 2e-26 91.8 0.1 2.4e-26 91.6 0.1 1.1 1 0 0 1 1 1 1 NapD protein GXWXG PF14231.6 CDK99220.1 - 0.15 12.1 0.0 0.56 10.3 0.0 1.9 1 1 1 2 2 2 0 GXWXG protein Fer4_6 PF12837.7 CDK99221.1 - 1.7e-07 31.0 3.0 1.7e-07 31.0 3.0 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_7 PF12838.7 CDK99221.1 - 2.2e-07 31.4 7.3 4e-07 30.5 7.4 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 CDK99221.1 - 7.6e-07 28.7 4.4 7.6e-07 28.7 4.4 2.4 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_9 PF13187.6 CDK99221.1 - 2.5e-06 27.6 5.7 2.5e-06 27.6 5.7 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDK99221.1 - 3e-06 27.3 7.0 4.4e-06 26.7 7.0 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDK99221.1 - 2.1e-05 24.4 3.6 2.1e-05 24.4 3.6 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_16 PF13484.6 CDK99221.1 - 3.5e-05 24.7 8.3 0.00032 21.6 2.3 2.2 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 CDK99221.1 - 9.7e-05 22.4 2.0 9.7e-05 22.4 2.0 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDK99221.1 - 0.00048 20.5 4.5 0.0029 18.0 0.6 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDK99221.1 - 0.0013 19.6 6.3 0.0013 19.6 6.3 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_4 PF12800.7 CDK99221.1 - 0.024 15.1 3.0 0.024 15.1 3.0 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 CDK99221.1 - 0.031 14.8 1.8 0.031 14.8 1.8 2.2 1 1 2 3 3 3 0 4Fe-4S dicluster domain Fer4_22 PF17179.4 CDK99221.1 - 0.073 13.9 1.4 0.073 13.9 1.4 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDK99221.1 - 1.5 9.0 11.1 0.52 10.5 2.7 2.1 1 1 0 2 2 2 0 4Fe-4S dicluster domain EAL PF00563.20 CDK99222.1 - 4.8e-71 239.0 0.0 8.5e-71 238.2 0.0 1.4 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK99222.1 - 1.5e-42 145.1 0.1 2.6e-42 144.3 0.1 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_4 PF08448.10 CDK99222.1 - 0.00027 21.2 0.3 0.17 12.1 0.0 3.0 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.7 CDK99222.1 - 0.00033 20.6 0.5 0.047 13.7 0.0 3.5 3 1 0 3 3 3 1 PAS domain PAS PF00989.25 CDK99222.1 - 0.0042 17.1 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 PAS fold NUDIX PF00293.28 CDK99223.1 - 1.4e-21 76.9 0.0 2.5e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 CDK99223.1 - 1.4e-12 48.2 0.6 2.3e-12 47.5 0.6 1.3 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 CDK99223.1 - 2.8e-09 36.5 6.3 5.3e-09 35.6 6.3 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Nudix_N_2 PF14803.6 CDK99223.1 - 4 7.4 5.0 10 6.1 5.0 1.7 1 1 0 1 1 1 0 Nudix N-terminal sCache_2 PF17200.4 CDK99224.1 - 8.6e-39 132.9 0.0 8.6e-39 132.9 0.0 2.7 2 1 0 2 2 2 1 Single Cache domain 2 dCache_2 PF08269.11 CDK99224.1 - 3.1e-38 131.6 3.7 6.9e-38 130.5 0.0 2.7 3 1 0 3 3 3 1 Cache domain MCPsignal PF00015.21 CDK99224.1 - 3.8e-32 111.5 45.1 1.3e-31 109.8 24.6 2.7 1 1 1 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Cache_3-Cache_2 PF17201.4 CDK99224.1 - 4.7e-10 39.2 0.1 4.7e-10 39.2 0.1 3.3 3 0 0 3 3 3 1 Cache 3/Cache 2 fusion domain DUF948 PF06103.11 CDK99224.1 - 2.5e-05 24.5 23.1 0.021 15.1 4.7 4.9 3 2 2 5 5 5 3 Bacterial protein of unknown function (DUF948) HAMP PF00672.25 CDK99224.1 - 0.00011 22.5 0.2 0.00011 22.5 0.2 4.8 4 2 0 4 4 4 1 HAMP domain DUF1664 PF07889.12 CDK99224.1 - 0.00039 20.4 9.2 0.75 9.8 1.2 3.8 2 2 2 4 4 4 4 Protein of unknown function (DUF1664) Laminin_I PF06008.14 CDK99224.1 - 0.011 15.5 6.4 0.011 15.5 6.4 2.9 1 1 0 2 2 2 0 Laminin Domain I HAP1_N PF04849.13 CDK99224.1 - 0.071 12.3 5.3 1.9 7.6 0.1 2.4 2 0 0 2 2 2 0 HAP1 N-terminal conserved region DUF3450 PF11932.8 CDK99224.1 - 0.079 12.3 20.6 0.14 11.4 2.7 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) FlgN PF05130.12 CDK99224.1 - 0.36 11.3 17.0 0.42 11.1 0.7 3.6 2 1 2 4 4 4 0 FlgN protein Syntaxin-6_N PF09177.11 CDK99224.1 - 0.38 11.3 9.3 2.1 8.9 1.5 3.5 2 2 1 3 3 3 0 Syntaxin 6, N-terminal HTH_Tnp_ISL3 PF13542.6 CDK99224.1 - 1 8.8 7.1 0.84 9.1 0.1 3.1 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 IFT57 PF10498.9 CDK99224.1 - 1.1 8.2 5.6 2.7 6.9 0.0 2.3 2 1 0 2 2 2 0 Intra-flagellar transport protein 57 Vps53_N PF04100.12 CDK99224.1 - 1.4 7.8 7.7 2.6 6.9 0.8 2.4 2 0 0 2 2 2 0 Vps53-like, N-terminal FlaC_arch PF05377.11 CDK99224.1 - 1.7 9.1 3.2 32 5.0 0.2 3.8 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Laminin_II PF06009.12 CDK99224.1 - 1.9 8.5 21.2 1.4 8.9 5.6 4.0 1 1 3 4 4 4 0 Laminin Domain II AAA_13 PF13166.6 CDK99224.1 - 2.1 6.9 12.4 0.78 8.3 8.6 1.9 1 1 1 2 2 2 0 AAA domain dCache_1 PF02743.18 CDK99224.1 - 7.4 6.3 7.7 8.8 6.0 0.0 3.4 2 1 0 3 3 3 0 Cache domain Fer4_20 PF14691.6 CDK99225.1 - 8.8e-25 86.7 0.2 1.4e-24 86.1 0.2 1.3 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 CDK99225.1 - 2.1e-24 86.3 8.2 6.7e-24 84.6 7.3 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDK99225.1 - 4.6e-10 39.6 0.2 4.6e-10 39.6 0.2 1.8 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CDK99225.1 - 7.7e-09 36.0 3.6 9.1e-05 22.9 0.9 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDK99225.1 - 1.2e-08 34.6 5.3 4.3e-05 22.9 0.3 4.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDK99225.1 - 1.2e-08 34.7 0.8 1.2e-08 34.7 0.8 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CDK99225.1 - 6.9e-07 28.3 4.7 7.5e-07 28.2 0.7 2.2 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_7 PF13241.6 CDK99225.1 - 1.2e-06 28.9 0.8 0.0021 18.5 0.3 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding Amino_oxidase PF01593.24 CDK99225.1 - 1.4e-06 27.9 1.6 2.4e-06 27.1 0.5 1.9 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase DAO PF01266.24 CDK99225.1 - 1.6e-05 24.7 0.5 1.6e-05 24.7 0.5 2.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDK99225.1 - 1.8e-05 24.0 2.9 1.8e-05 24.0 2.9 1.8 2 0 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 CDK99225.1 - 2.3e-05 23.8 0.8 2.3e-05 23.8 0.8 1.7 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 CDK99225.1 - 2.3e-05 23.7 0.1 2.3e-05 23.7 0.1 1.6 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 CDK99225.1 - 3.9e-05 23.1 5.2 0.0039 16.5 0.3 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 CDK99225.1 - 0.00015 21.0 2.2 0.00015 21.0 2.2 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A K_oxygenase PF13434.6 CDK99225.1 - 0.0013 17.9 0.2 0.51 9.4 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 CDK99225.1 - 0.0015 17.1 0.2 0.02 13.3 0.0 2.0 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like DJ-1_PfpI PF01965.24 CDK99225.1 - 0.0029 17.4 1.2 0.022 14.6 1.0 2.5 1 1 0 1 1 1 1 DJ-1/PfpI family AdoHcyase_NAD PF00670.21 CDK99225.1 - 0.0038 17.3 6.0 0.045 13.8 1.3 2.3 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.18 CDK99225.1 - 0.0048 16.8 0.3 0.0048 16.8 0.3 1.7 2 0 0 2 2 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 CDK99225.1 - 0.0086 16.1 1.0 0.035 14.1 0.4 2.4 2 1 0 2 2 2 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CDK99225.1 - 0.01 14.9 3.8 0.013 14.6 1.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 CDK99225.1 - 0.011 15.1 0.6 0.053 12.9 0.1 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CDK99225.1 - 0.017 15.7 2.6 0.21 12.2 0.3 3.0 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 CDK99225.1 - 0.037 14.0 0.0 0.075 13.0 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus YjeF_N PF03853.15 CDK99225.1 - 0.078 12.9 0.9 0.45 10.4 0.1 2.3 2 0 0 2 2 2 0 YjeF-related protein N-terminus TrkA_N PF02254.18 CDK99225.1 - 0.08 13.2 1.1 0.28 11.5 0.0 2.2 2 0 0 2 2 2 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 CDK99225.1 - 0.12 11.9 0.1 0.12 11.9 0.1 1.6 2 0 0 2 2 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Rossmann-like PF10727.9 CDK99225.1 - 0.17 11.7 1.9 0.35 10.7 0.7 2.2 2 1 0 2 2 1 0 Rossmann-like domain Trp_halogenase PF04820.14 CDK99225.1 - 0.31 9.8 4.9 0.087 11.7 0.7 1.9 2 0 0 2 2 2 0 Tryptophan halogenase IlvN PF07991.12 CDK99225.1 - 0.68 9.5 4.1 0.26 10.8 0.4 2.0 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Fer4_9 PF13187.6 CDK99225.1 - 1 9.6 5.1 0.43 10.8 1.1 1.9 1 1 2 3 3 3 0 4Fe-4S dicluster domain GATase_2 PF00310.21 CDK99226.1 - 1.4e-184 613.7 0.0 1.9e-184 613.3 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 CDK99226.1 - 2.7e-158 526.9 0.1 6.8e-155 515.7 0.0 2.3 2 0 0 2 2 2 2 Conserved region in glutamate synthase Glu_syn_central PF04898.14 CDK99226.1 - 2.6e-115 384.7 0.0 1.2e-114 382.6 0.0 1.9 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 CDK99226.1 - 1.7e-80 269.1 8.5 2.9e-80 268.4 8.5 1.4 1 0 0 1 1 1 1 GXGXG motif FMN_dh PF01070.18 CDK99226.1 - 0.047 12.7 0.4 0.13 11.3 0.4 1.6 2 0 0 2 2 2 0 FMN-dependent dehydrogenase MCPsignal PF00015.21 CDK99227.1 - 8.8e-26 90.7 37.7 7e-25 87.8 27.3 2.8 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain Protoglobin PF11563.8 CDK99227.1 - 1.7e-18 67.0 1.0 4.4e-18 65.7 1.0 1.7 1 0 0 1 1 1 1 Protoglobin Apolipoprotein PF01442.18 CDK99227.1 - 0.0041 17.0 7.3 0.0041 17.0 7.3 3.0 1 1 1 2 2 2 1 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 CDK99227.1 - 0.052 13.6 7.9 1.4 9.0 0.2 3.4 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 CDK99227.1 - 0.15 10.7 5.2 0.21 10.2 5.2 1.2 1 0 0 1 1 1 0 AAA domain DUF948 PF06103.11 CDK99227.1 - 1.7 8.9 20.8 7.1 7.0 1.9 4.7 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) AIP3 PF03915.13 CDK99227.1 - 2.3 7.2 7.3 2.1 7.4 1.4 2.1 1 1 0 2 2 2 0 Actin interacting protein 3 DUF725 PF05267.12 CDK99227.1 - 3.5 7.6 7.4 8.3 6.4 0.5 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF725) Flg_bbr_C PF06429.13 CDK99228.1 - 2.4e-16 59.6 0.6 1.3e-15 57.3 0.1 2.6 3 0 0 3 3 3 1 Flagellar basal body rod FlgEFG protein C-terminal FlaE PF07559.14 CDK99228.1 - 1.4e-13 51.5 17.1 5.9e-12 46.2 0.9 3.5 3 1 1 4 4 4 2 Flagellar basal body protein FlaE Flg_bb_rod PF00460.20 CDK99228.1 - 0.00017 21.4 2.1 0.00017 21.4 2.1 2.1 2 0 0 2 2 2 1 Flagella basal body rod protein Peripla_BP_5 PF13433.6 CDK99229.1 - 4.3e-165 549.1 0.0 5e-165 548.8 0.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_6 PF13458.6 CDK99229.1 - 2e-74 251.3 6.5 2.6e-74 250.9 6.5 1.1 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.28 CDK99229.1 - 0.00019 20.6 0.0 0.0004 19.6 0.0 1.7 1 1 0 1 1 1 1 Receptor family ligand binding region Glyco_tran_WecB PF03808.13 CDK99229.1 - 0.026 14.5 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family HATPase_c PF02518.26 CDK99230.1 - 1.5e-25 89.9 0.0 2.4e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK99230.1 - 1e-23 83.6 0.0 2.7e-23 82.3 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CDK99230.1 - 2.4e-18 65.9 0.5 8.7e-18 64.1 0.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDK99230.1 - 3.1e-13 49.9 2.4 5.4e-13 49.1 0.0 2.7 3 0 0 3 3 3 1 HAMP domain dCache_1 PF02743.18 CDK99230.1 - 1.8e-08 34.5 0.0 3.6e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Cache domain Hpt PF01627.23 CDK99230.1 - 1.7e-07 31.4 7.2 1.7e-07 31.4 7.2 2.8 2 0 0 2 2 2 1 Hpt domain dCache_3 PF14827.6 CDK99230.1 - 0.0056 16.4 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 Double sensory domain of two-component sensor kinase HATPase_c_3 PF13589.6 CDK99230.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK99231.1 - 1.9e-26 92.4 0.0 2.6e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK99231.1 - 1.2e-19 70.1 0.0 2.2e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Peripla_BP_5 PF13433.6 CDK99232.1 - 1.9e-173 576.6 1.8 2.1e-173 576.4 1.8 1.0 1 0 0 1 1 1 1 Periplasmic binding protein domain Peripla_BP_6 PF13458.6 CDK99232.1 - 3.3e-69 234.2 3.2 3.9e-69 233.9 3.2 1.0 1 0 0 1 1 1 1 Periplasmic binding protein ANF_receptor PF01094.28 CDK99232.1 - 0.0007 18.8 0.0 0.0045 16.1 0.0 1.9 2 0 0 2 2 2 1 Receptor family ligand binding region DUF2877 PF11392.8 CDK99232.1 - 0.15 12.8 0.2 3.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) BPD_transp_2 PF02653.16 CDK99233.1 - 1.8e-49 168.3 40.7 2.6e-49 167.8 40.7 1.2 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component HEAT_2 PF13646.6 CDK99233.1 - 6.6e-08 32.8 22.6 0.0032 17.8 0.2 3.4 3 0 0 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 CDK99233.1 - 0.37 11.6 14.0 2.1 9.3 4.0 5.0 3 1 1 4 4 4 0 PBS lyase HEAT-like repeat BPD_transp_2 PF02653.16 CDK99234.1 - 1.4e-43 149.0 36.0 2.1e-43 148.4 36.0 1.3 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component ABC_tran PF00005.27 CDK99235.1 - 1.7e-28 99.8 0.1 2.4e-28 99.3 0.1 1.2 1 0 0 1 1 1 1 ABC transporter BCA_ABC_TP_C PF12399.8 CDK99235.1 - 2.1e-06 27.5 0.1 3.5e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_21 PF13304.6 CDK99235.1 - 2.8e-06 27.3 0.2 0.0047 16.8 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK99235.1 - 1.9e-05 24.2 0.1 0.0032 16.9 0.0 2.0 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDK99235.1 - 0.00019 22.0 0.1 0.00034 21.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDK99235.1 - 0.0014 18.3 0.0 0.0029 17.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 CDK99235.1 - 0.0017 18.1 0.6 0.0092 15.7 0.6 2.1 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CDK99235.1 - 0.0021 17.8 0.0 0.0025 17.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain DUF2813 PF11398.8 CDK99235.1 - 0.052 12.8 0.0 0.073 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) AAA_27 PF13514.6 CDK99235.1 - 0.061 12.9 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDK99235.1 - 0.072 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 CDK99236.1 - 5.4e-30 104.7 0.0 7.3e-30 104.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK99236.1 - 1.8e-10 41.1 0.0 0.00029 20.8 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK99236.1 - 0.00082 18.9 0.0 0.0037 16.7 0.0 1.8 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDK99236.1 - 0.0011 18.9 0.1 0.0017 18.3 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDK99236.1 - 0.0026 18.2 0.1 0.0042 17.5 0.1 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CDK99236.1 - 0.0043 17.6 0.0 0.006 17.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CDK99236.1 - 0.0061 16.3 0.6 0.066 12.9 0.1 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein MMR_HSR1 PF01926.23 CDK99236.1 - 0.0067 16.5 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 CDK99236.1 - 0.011 15.7 0.1 0.022 14.6 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 CDK99236.1 - 0.019 15.4 0.0 0.045 14.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 CDK99236.1 - 0.024 14.3 0.0 0.039 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CDK99236.1 - 0.032 14.0 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 CDK99236.1 - 0.039 14.2 0.5 0.16 12.2 0.5 2.0 1 1 0 1 1 1 0 AAA domain Roc PF08477.13 CDK99236.1 - 0.047 13.9 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 CDK99236.1 - 0.061 13.0 0.2 0.18 11.5 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CDK99236.1 - 0.068 13.2 0.1 10 6.2 0.1 2.4 2 1 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 CDK99236.1 - 0.12 12.0 0.4 0.1 12.3 0.4 1.2 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.22 CDK99236.1 - 0.21 10.8 0.1 0.98 8.5 0.1 1.8 2 0 0 2 2 2 0 NB-ARC domain UreD PF01774.17 CDK99237.1 - 1.9e-42 145.6 3.1 2.3e-42 145.3 3.1 1.1 1 0 0 1 1 1 1 UreD urease accessory protein Urease_gamma PF00547.18 CDK99238.1 - 8.8e-47 157.5 0.2 9.7e-47 157.3 0.2 1.0 1 0 0 1 1 1 1 Urease, gamma subunit Herpes_UL36 PF03586.13 CDK99238.1 - 0.1 11.9 0.1 5.8 6.2 0.0 2.0 1 1 1 2 2 2 0 Herpesvirus UL36 tegument protein Rib PF08428.10 CDK99238.1 - 0.11 12.4 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Rib/alpha-like repeat Urease_beta PF00699.20 CDK99239.1 - 7.2e-46 154.2 0.0 8e-46 154.1 0.0 1.0 1 0 0 1 1 1 1 Urease beta subunit Amidohydro_1 PF01979.20 CDK99240.1 - 9.5e-79 265.2 2.5 1.3e-78 264.7 2.5 1.1 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 CDK99240.1 - 5.1e-58 194.7 2.2 1.1e-57 193.6 2.2 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Amidohydro_3 PF07969.11 CDK99240.1 - 2.4e-09 37.2 3.9 0.00022 20.8 0.3 3.3 1 1 1 2 2 2 2 Amidohydrolase family UreE_C PF05194.12 CDK99241.1 - 7.6e-19 68.0 0.0 1.1e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 UreE urease accessory protein, C-terminal domain UreE_N PF02814.15 CDK99241.1 - 1.4e-15 56.6 0.2 2.3e-15 55.9 0.2 1.3 1 0 0 1 1 1 1 UreE urease accessory protein, N-terminal domain UreF PF01730.16 CDK99242.1 - 1.3e-32 113.2 10.3 1.3e-32 113.2 10.3 1.6 2 0 0 2 2 2 1 UreF cobW PF02492.19 CDK99243.1 - 1.5e-33 115.8 0.0 1.8e-33 115.6 0.0 1.0 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CDK99243.1 - 0.0041 16.1 0.0 1 8.3 0.0 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB NAD_synthase PF02540.17 CDK99244.1 - 1.3e-70 237.3 0.0 1.9e-70 236.7 0.0 1.2 1 0 0 1 1 1 1 NAD synthase CN_hydrolase PF00795.22 CDK99244.1 - 5.9e-32 111.0 0.0 8.6e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase tRNA_Me_trans PF03054.16 CDK99244.1 - 0.068 11.9 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 tRNA methyl transferase AAA_31 PF13614.6 CDK99246.1 - 2.3e-45 154.7 0.0 3.2e-45 154.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CDK99246.1 - 6.5e-21 74.7 0.0 1.1e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 CDK99246.1 - 1.2e-11 44.5 0.4 8e-07 28.6 0.5 2.2 2 0 0 2 2 2 2 ATPase MipZ ParA PF10609.9 CDK99246.1 - 5.7e-11 42.3 2.1 1.5e-08 34.4 0.2 2.3 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 CDK99246.1 - 1.6e-10 40.9 0.1 1.3e-09 37.9 0.1 2.2 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 CDK99246.1 - 7.1e-09 35.5 0.1 3.3e-05 23.5 0.1 2.1 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 CDK99246.1 - 7.5e-06 25.3 0.4 1.3e-05 24.5 0.4 1.3 1 0 0 1 1 1 1 Anion-transporting ATPase VirC1 PF07015.11 CDK99246.1 - 0.0024 17.2 1.2 0.005 16.2 0.2 1.8 2 0 0 2 2 2 1 VirC1 protein AAA_25 PF13481.6 CDK99246.1 - 0.079 12.5 0.1 0.18 11.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 CDK99246.1 - 0.12 12.1 0.3 0.37 10.6 0.1 1.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SRP54 PF00448.22 CDK99246.1 - 0.18 11.4 0.2 0.3 10.7 0.2 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain HTH_27 PF13463.6 CDK99247.1 - 4.5e-16 59.1 0.3 8e-16 58.3 0.0 1.6 2 0 0 2 2 2 1 Winged helix DNA-binding domain MarR_2 PF12802.7 CDK99247.1 - 7.6e-07 28.9 0.0 1.5e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.6 CDK99247.1 - 0.00037 20.6 0.0 0.00055 20.1 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.22 CDK99247.1 - 0.0015 18.4 0.0 0.0038 17.1 0.0 1.7 2 0 0 2 2 2 1 MarR family HTH_20 PF12840.7 CDK99247.1 - 0.049 13.7 0.1 0.1 12.6 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Lyase_1 PF00206.20 CDK99248.1 - 1.7e-55 188.6 0.0 2.6e-55 188.0 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 CDK99248.1 - 2.9e-28 98.2 0.8 1.4e-27 96.0 0.3 2.2 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus ASL_C PF08328.11 CDK99248.1 - 0.023 14.8 0.0 0.084 13.0 0.0 1.9 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminal DUF1476 PF07345.11 CDK99249.1 - 6.4e-36 122.8 5.0 7.3e-36 122.6 5.0 1.0 1 0 0 1 1 1 1 ATPase inhibitor subunit zeta Peptidase_S13 PF02113.15 CDK99249.1 - 0.016 13.9 0.0 0.026 13.3 0.0 1.3 1 1 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family TANGO2 PF05742.12 CDK99250.1 - 1.3e-23 84.4 0.0 1.4e-23 84.3 0.0 1.2 1 0 0 1 1 1 1 Transport and Golgi organisation 2 MCPsignal PF00015.21 CDK99251.1 - 2.2e-27 95.9 61.5 1.7e-25 89.8 23.6 6.7 3 1 3 6 6 6 5 Methyl-accepting chemotaxis protein (MCP) signalling domain PilZ PF07238.14 CDK99251.1 - 0.00049 20.4 0.0 0.001 19.4 0.0 1.6 1 0 0 1 1 1 1 PilZ domain DUF948 PF06103.11 CDK99251.1 - 0.1 12.8 37.8 0.57 10.5 5.6 7.1 3 2 4 7 7 7 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 CDK99251.1 - 1.8 8.6 26.8 0.076 13.1 2.4 5.9 4 2 3 7 7 7 0 Protein of unknown function (DUF1664) HAMP PF00672.25 CDK99251.1 - 3.1 8.3 13.2 1.1 9.7 1.0 5.4 5 1 0 5 5 5 0 HAMP domain SAICAR_synt PF01259.18 CDK99252.1 - 6e-62 209.5 0.0 6.8e-62 209.3 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase PurS PF02700.14 CDK99253.1 - 1.2e-34 118.3 0.0 1.3e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoribosylformylglycinamidine (FGAM) synthase Na_sulph_symp PF00939.19 CDK99254.1 - 4.3e-27 95.3 28.7 5.5e-27 94.9 28.7 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 CDK99254.1 - 1.2e-05 24.6 39.9 1.2e-05 24.6 39.9 2.1 2 1 0 2 2 2 1 Citrate transporter Microcin PF03526.13 CDK99254.1 - 0.11 12.3 0.1 0.3 10.9 0.1 1.7 1 0 0 1 1 1 0 Colicin E1 (microcin) immunity protein PK PF00224.21 CDK99255.1 - 8.3e-113 376.8 0.0 1.1e-112 376.4 0.0 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CDK99255.1 - 2e-31 108.6 0.9 4.7e-31 107.4 0.9 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 CDK99255.1 - 0.0013 17.9 0.6 0.065 12.4 0.0 3.3 2 1 2 4 4 4 1 HpcH/HpaI aldolase/citrate lyase family FCD PF07729.12 CDK99256.1 - 5.6e-25 88.2 6.8 1.1e-24 87.2 6.8 1.5 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 CDK99256.1 - 1e-20 73.1 0.6 2.4e-20 72.0 0.6 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family FadR_C PF07840.12 CDK99256.1 - 3.4e-05 23.8 0.0 4.8e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 FadR C-terminal domain HTH_Crp_2 PF13545.6 CDK99256.1 - 0.00018 21.4 0.4 0.00056 19.8 0.2 1.9 1 1 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_11 PF08279.12 CDK99256.1 - 0.00031 20.6 0.0 0.00099 19.0 0.0 1.8 1 0 0 1 1 1 1 HTH domain Rrf2 PF02082.20 CDK99256.1 - 0.00063 20.0 0.1 0.002 18.4 0.1 2.0 1 1 0 1 1 1 1 Transcriptional regulator Fe_dep_repress PF01325.19 CDK99256.1 - 0.0061 16.7 0.1 0.017 15.3 0.0 1.8 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain PaaX PF07848.12 CDK99256.1 - 0.016 15.4 0.2 0.035 14.3 0.2 1.5 1 0 0 1 1 1 0 PaaX-like protein TrmB PF01978.19 CDK99256.1 - 0.038 13.9 0.1 0.16 11.8 0.0 2.1 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB HTH_DeoR PF08220.12 CDK99256.1 - 0.05 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_29 PF13551.6 CDK99256.1 - 0.056 13.5 0.4 0.94 9.6 0.2 2.6 1 1 1 2 2 2 0 Winged helix-turn helix HTH_41 PF14502.6 CDK99256.1 - 0.096 12.4 0.1 0.23 11.2 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_IclR PF09339.10 CDK99256.1 - 0.1 12.4 0.1 0.1 12.4 0.1 2.6 3 0 0 3 3 3 0 IclR helix-turn-helix domain EamA PF00892.20 CDK99257.1 - 1.3e-26 93.4 38.5 3e-15 56.6 17.3 2.0 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CDK99257.1 - 0.00062 19.1 3.7 0.00099 18.4 3.7 1.4 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 CDK99257.1 - 0.0038 16.6 14.2 0.19 11.1 7.2 2.5 2 1 1 3 3 3 2 Triose-phosphate Transporter family FAA_hydrolase PF01557.18 CDK99258.1 - 1e-65 221.4 0.0 1.2e-65 221.2 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family EAL PF00563.20 CDK99259.1 - 1.2e-70 237.7 0.2 3.3e-70 236.3 0.0 1.8 2 0 0 2 2 2 1 EAL domain GGDEF PF00990.21 CDK99259.1 - 5.8e-53 178.9 0.0 1.1e-52 178.0 0.0 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDK99259.1 - 1.9e-26 92.3 0.0 1.3e-12 47.9 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 CDK99259.1 - 6.2e-26 90.6 0.0 4.9e-13 49.1 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 CDK99259.1 - 1.2e-23 83.4 0.6 3.5e-11 43.3 0.1 3.6 3 0 0 3 3 3 2 PAS fold PAS_3 PF08447.12 CDK99259.1 - 2.3e-21 75.9 0.0 6.4e-10 39.2 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 CDK99259.1 - 2.7e-21 75.1 1.7 1e-08 35.0 0.0 3.8 3 0 0 3 3 3 3 PAS domain Response_reg PF00072.24 CDK99259.1 - 2.1e-18 66.5 0.0 5.4e-18 65.2 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain PAS_7 PF12860.7 CDK99259.1 - 1.3e-05 25.3 0.7 1.9 8.7 0.1 4.2 3 1 0 3 3 3 2 PAS fold TadZ_N PF16968.5 CDK99259.1 - 0.0061 16.3 0.3 0.016 14.9 0.3 1.7 1 0 0 1 1 1 1 Pilus assembly protein TadZ N-terminal PAS_12 PF18095.1 CDK99259.1 - 0.0093 15.6 0.0 0.046 13.4 0.0 2.0 2 0 0 2 2 2 1 UPF0242 C-terminal PAS-like domain Response_reg PF00072.24 CDK99260.1 - 2.8e-18 66.1 0.0 3.3e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain cNMP_binding PF00027.29 CDK99261.1 - 3e-15 56.1 0.0 4.9e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 CDK99261.1 - 1.1e-12 47.8 0.1 2.4e-12 46.6 0.1 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain MarR_2 PF12802.7 CDK99261.1 - 0.6 10.0 5.2 0.25 11.2 0.6 2.7 3 1 0 3 3 3 0 MarR family DsrC PF04358.13 CDK99262.1 - 6.5e-30 103.8 0.0 7.7e-30 103.6 0.0 1.0 1 0 0 1 1 1 1 DsrC like protein LexA_DNA_bind PF01726.16 CDK99262.1 - 0.01 15.6 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 LexA DNA binding domain FAD_binding_4 PF01565.23 CDK99263.1 - 2.6e-06 27.2 3.3 7.1e-05 22.6 3.3 2.8 1 1 0 1 1 1 1 FAD binding domain DUF445 PF04286.12 CDK99264.1 - 6.3e-66 223.7 0.0 9.3e-42 144.1 0.0 2.9 1 1 1 2 2 2 2 Protein of unknown function (DUF445) FemAB_like PF04339.12 CDK99265.1 - 2.4e-150 500.8 0.4 2.7e-150 500.6 0.4 1.0 1 0 0 1 1 1 1 Peptidogalycan biosysnthesis/recognition Acetyltransf_6 PF13480.7 CDK99265.1 - 8.2e-10 39.0 4.7 1e-09 38.6 1.3 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Response_reg PF00072.24 CDK99266.1 - 1.4e-09 38.1 0.0 1.8e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain MSP1a PF11670.8 CDK99267.1 - 0.00081 18.8 0.7 0.00092 18.6 0.7 1.1 1 0 0 1 1 1 1 Major surface protein 1a (MSP1a) ECM11 PF15463.6 CDK99267.1 - 0.0085 16.7 5.2 0.015 15.8 2.6 2.1 2 0 0 2 2 2 1 Extracellular mutant protein 11 PL48 PF15903.5 CDK99267.1 - 0.021 13.8 1.9 0.036 13.1 1.9 1.3 1 0 0 1 1 1 0 Filopodia upregulated, FAM65 Dynamitin PF04912.14 CDK99267.1 - 0.056 12.8 0.6 0.067 12.5 0.6 1.3 1 1 0 1 1 1 0 Dynamitin Sm_like PF16243.5 CDK99267.1 - 0.078 13.1 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Sm_like domain BST2 PF16716.5 CDK99267.1 - 0.12 13.0 1.7 1.9 9.1 0.5 2.2 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DUF2721 PF11026.8 CDK99267.1 - 1.6 8.7 5.4 0.49 10.3 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Response_reg PF00072.24 CDK99268.1 - 4.3e-29 100.9 0.1 4.8e-29 100.8 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain RNase_T PF00929.24 CDK99269.1 - 3.5e-25 89.5 0.0 5.2e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 CDK99269.1 - 6.3e-05 22.8 0.0 0.16 11.7 0.0 2.4 2 0 0 2 2 2 2 3'-5' exonuclease CAF1 PF04857.20 CDK99269.1 - 0.25 10.5 0.0 0.97 8.5 0.0 1.8 2 0 0 2 2 2 0 CAF1 family ribonuclease DUF3311 PF11755.8 CDK99270.1 - 0.054 13.4 4.1 0.085 12.8 4.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3311) HATPase_c PF02518.26 CDK99271.1 - 1.1e-26 93.6 0.0 2.1e-26 92.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK99271.1 - 7.9e-17 61.1 0.1 7.9e-17 61.1 0.1 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 CDK99271.1 - 0.0014 18.5 0.0 0.0032 17.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HI0933_like PF03486.14 CDK99272.1 - 4.8e-135 450.4 0.0 5.4e-135 450.2 0.0 1.0 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 CDK99272.1 - 3.8e-12 46.0 2.6 7e-10 38.5 0.1 3.1 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CDK99272.1 - 5.3e-09 35.7 0.2 9.1e-09 35.0 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDK99272.1 - 1.5e-07 31.0 3.2 0.0032 16.8 2.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDK99272.1 - 1.1e-06 28.8 2.0 2.8e-06 27.5 2.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CDK99272.1 - 5.5e-06 26.0 0.3 6.9e-06 25.7 0.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 CDK99272.1 - 2e-05 24.4 9.7 0.00079 19.1 2.1 2.6 2 1 1 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 CDK99272.1 - 0.00016 20.9 10.5 0.0073 15.4 2.6 2.4 3 0 0 3 3 3 2 Glucose inhibited division protein A Thi4 PF01946.17 CDK99272.1 - 0.00082 18.7 0.6 0.0015 17.9 0.6 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CDK99272.1 - 0.0012 18.0 1.2 0.0043 16.1 1.1 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 CDK99272.1 - 0.0017 17.7 0.3 0.0036 16.6 0.3 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 CDK99272.1 - 0.0036 16.6 0.3 0.0057 15.9 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CDK99272.1 - 0.0069 16.9 0.2 0.082 13.5 0.5 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DUF1120 PF06551.12 CDK99272.1 - 0.11 12.7 0.1 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1120) Amino_oxidase PF01593.24 CDK99272.1 - 0.2 10.9 1.4 40 3.3 0.0 3.0 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase TPR_10 PF13374.6 CDK99273.1 - 5.1e-06 26.2 0.4 5.1e-06 26.2 0.4 6.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDK99273.1 - 0.0037 17.5 21.5 2.9 8.3 2.9 6.0 4 2 1 5 5 5 2 Tetratricopeptide repeat DUF3856 PF12968.7 CDK99273.1 - 1.1 9.3 11.0 6.3 6.9 0.2 3.2 1 1 2 3 3 3 0 Domain of Unknown Function (DUF3856) ANAPC5 PF12862.7 CDK99273.1 - 1.3 9.1 6.6 12 6.1 3.1 3.2 2 2 0 2 2 2 0 Anaphase-promoting complex subunit 5 DUF1849 PF08904.11 CDK99274.1 - 5.7e-79 265.2 0.0 6.5e-79 265.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1849) bMG10 PF17973.1 CDK99277.1 - 0.0085 16.3 0.0 0.011 15.9 0.0 1.2 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain YrzK PF17449.2 CDK99277.1 - 0.089 13.1 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized YrzK-like PhaC_N PF07167.13 CDK99278.1 - 2.4e-61 206.4 0.1 4.4e-61 205.5 0.1 1.5 1 0 0 1 1 1 1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus PHBC_N PF12551.8 CDK99278.1 - 1.5e-18 66.2 0.1 1.5e-18 66.2 0.1 1.8 2 0 0 2 2 2 1 Poly-beta-hydroxybutyrate polymerase N terminal Abhydrolase_1 PF00561.20 CDK99278.1 - 1.5e-13 51.0 0.0 3.5e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF3141 PF11339.8 CDK99278.1 - 0.028 12.8 0.0 0.047 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) FliMN_C PF01052.20 CDK99279.1 - 1.2e-23 82.9 1.3 1.3e-23 82.7 1.3 1.0 1 0 0 1 1 1 1 Type III flagellar switch regulator (C-ring) FliN C-term Ribosomal_S21e PF01249.18 CDK99279.1 - 0.073 13.2 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein S21e TAL_FSA PF00923.19 CDK99280.1 - 2.5e-58 197.7 0.0 2.6e-56 191.1 0.0 2.4 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase CxxCxxCC PF03692.15 CDK99281.1 - 7.1e-10 39.4 0.1 1.7e-09 38.2 0.1 1.7 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain UPF0225 PF17775.1 CDK99282.1 - 2.2e-23 82.9 0.1 2.7e-23 82.7 0.1 1.1 1 0 0 1 1 1 1 UPF0225 domain SEC-C PF02810.15 CDK99282.1 - 3.2e-14 52.5 24.6 3.8e-10 39.5 12.2 2.2 2 0 0 2 2 2 2 SEC-C motif SnoaL_3 PF13474.6 CDK99282.1 - 0.0076 16.5 0.6 0.046 14.0 0.6 2.0 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 CDK99282.1 - 0.18 12.3 1.1 4.6 7.7 1.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) DUF3768 PF12599.8 CDK99282.1 - 0.18 11.8 0.2 0.33 11.0 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3768) tRNA-synt_1f PF01921.18 CDK99283.1 - 5.3e-129 430.2 0.0 6.4e-129 430.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (K) tRNA-synt_1b PF00579.25 CDK99283.1 - 0.0027 17.1 0.0 0.024 14.0 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (W and Y) tRNA-synt_1 PF00133.22 CDK99283.1 - 0.015 13.6 0.0 0.022 13.0 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CDK99283.1 - 0.019 13.7 0.0 0.032 13.0 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (M) Crust_neurohorm PF01147.17 CDK99283.1 - 0.065 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family tRNA-synt_1e PF01406.19 CDK99283.1 - 0.13 11.6 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain EAL PF00563.20 CDK99284.1 - 1.3e-68 231.1 0.0 3.2e-68 229.8 0.0 1.7 2 0 0 2 2 2 1 EAL domain GGDEF PF00990.21 CDK99284.1 - 2.9e-51 173.4 0.1 6.5e-51 172.3 0.1 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_4 PF08448.10 CDK99284.1 - 1.1e-26 93.2 0.0 3.5e-12 46.5 0.0 4.4 3 1 0 3 3 3 3 PAS fold PAS_9 PF13426.7 CDK99284.1 - 4e-19 68.8 0.0 1.7e-09 37.9 0.0 3.6 3 0 0 3 3 3 3 PAS domain PAS PF00989.25 CDK99284.1 - 8.3e-19 67.7 0.0 5.4e-06 26.4 0.0 3.9 3 0 0 3 3 3 3 PAS fold PAS_8 PF13188.7 CDK99284.1 - 5.8e-07 29.4 0.1 0.0015 18.5 0.0 4.2 4 0 0 4 4 4 1 PAS domain PAS_7 PF12860.7 CDK99284.1 - 0.0002 21.5 0.0 4.1 7.6 0.0 4.0 3 1 0 3 3 3 2 PAS fold DUF4287 PF14117.6 CDK99284.1 - 0.092 12.9 0.0 7.9 6.7 0.0 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4287) CheX PF13690.6 CDK99285.1 - 1.1e-16 60.7 0.0 3.8e-08 33.4 0.0 3.3 2 1 0 3 3 3 2 Chemotaxis phosphatase CheX CheC PF04509.12 CDK99285.1 - 2.9e-09 36.7 1.6 1.3e-06 28.2 0.0 2.6 3 0 0 3 3 3 2 CheC-like family Response_reg PF00072.24 CDK99286.1 - 1.9e-22 79.5 0.0 2.1e-22 79.4 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain TerB PF05099.13 CDK99287.1 - 0.00016 21.6 1.5 0.00077 19.4 1.5 2.3 1 1 0 1 1 1 1 Tellurite resistance protein TerB PAD PF03068.15 CDK99287.1 - 0.048 12.7 0.0 0.048 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) SSF PF00474.17 CDK99288.1 - 1.1e-51 176.0 35.7 6.1e-31 107.7 17.9 3.2 3 0 0 3 3 3 3 Sodium:solute symporter family DUF4407 PF14362.6 CDK99288.1 - 2.2e-05 24.0 1.4 2.2e-05 24.0 1.4 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4407) DUF4212 PF13937.6 CDK99289.1 - 4.7e-28 97.4 9.7 5.3e-28 97.2 9.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4212) DUF997 PF06196.12 CDK99289.1 - 0.049 13.6 8.9 0.061 13.3 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF997) Vma12 PF11712.8 CDK99289.1 - 0.082 13.0 1.7 0.09 12.8 1.7 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Synaptobrevin PF00957.21 CDK99289.1 - 0.62 9.9 3.4 0.4 10.5 0.3 1.9 2 0 0 2 2 2 0 Synaptobrevin TPR_1 PF00515.28 CDK99290.1 - 1.3e-19 69.1 0.7 0.00033 20.4 0.0 5.1 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 CDK99290.1 - 4.2e-18 63.9 2.3 0.00088 19.2 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDK99290.1 - 4.2e-17 60.9 0.1 0.0018 18.4 0.0 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 CDK99290.1 - 1.2e-15 57.8 5.7 1.5e-05 25.4 0.6 3.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDK99290.1 - 3.4e-15 55.4 13.9 0.00011 22.8 0.1 5.1 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDK99290.1 - 8.5e-15 54.2 0.6 0.00023 20.8 0.0 3.5 1 1 2 3 3 3 3 TPR repeat TPR_17 PF13431.6 CDK99290.1 - 1.5e-11 43.8 1.7 0.055 13.9 0.1 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDK99290.1 - 2.4e-11 44.1 12.9 1.5e-05 25.6 2.7 3.7 1 1 1 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CDK99290.1 - 3.6e-10 39.9 0.3 2.2e-06 27.8 0.0 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CDK99290.1 - 9.8e-10 37.8 2.7 0.02 14.9 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDK99290.1 - 3.4e-09 36.9 7.2 0.0017 18.6 0.1 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDK99290.1 - 1.1e-08 35.2 3.0 0.077 13.7 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDK99290.1 - 1.6e-06 28.2 10.9 0.00044 20.3 2.1 3.6 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_4 PF07721.14 CDK99290.1 - 4.1e-06 26.9 16.8 0.00088 19.7 0.5 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat BTAD PF03704.17 CDK99290.1 - 7e-05 23.3 3.1 0.00041 20.8 2.8 2.2 1 1 0 1 1 1 1 Bacterial transcriptional activator domain TPR_15 PF13429.6 CDK99290.1 - 0.00097 18.4 6.5 0.0043 16.3 1.8 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDK99290.1 - 0.0023 18.0 0.0 0.026 14.6 0.0 2.2 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_5 PF12688.7 CDK99290.1 - 0.0081 16.4 0.8 3.8 7.8 0.1 2.8 1 1 2 3 3 3 1 Tetratrico peptide repeat TPR_10 PF13374.6 CDK99290.1 - 0.012 15.5 9.1 2.4 8.1 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.6 CDK99290.1 - 0.013 15.8 5.3 6.1 7.2 0.3 3.6 1 1 3 4 4 4 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 CDK99290.1 - 0.026 14.1 0.5 0.8 9.4 0.1 2.3 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) DUF5588 PF17826.1 CDK99290.1 - 0.065 12.1 0.0 0.091 11.6 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5588) TPR_MalT PF17874.1 CDK99290.1 - 0.073 12.4 3.7 0.38 10.1 0.5 2.3 1 1 1 2 2 2 0 MalT-like TPR region SRP_TPR_like PF17004.5 CDK99290.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative TPR-like repeat ChAPs PF09295.10 CDK99290.1 - 0.22 10.5 0.0 0.52 9.3 0.0 1.6 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) YGGT PF02325.17 CDK99291.1 - 0.0096 16.3 1.9 0.019 15.4 1.9 1.6 1 1 0 1 1 1 1 YGGT family DUF294 PF03445.13 CDK99292.1 - 5.4e-37 126.7 0.4 8.9e-37 126.0 0.4 1.3 1 0 0 1 1 1 1 Putative nucleotidyltransferase DUF294 DUF294_C PF10335.9 CDK99292.1 - 4e-36 124.0 0.2 9.1e-36 122.8 0.2 1.7 1 0 0 1 1 1 1 Putative nucleotidyltransferase substrate binding domain CBS PF00571.28 CDK99292.1 - 1.9e-18 66.7 2.1 1.3e-12 47.9 0.2 2.4 2 0 0 2 2 2 2 CBS domain RNase_T PF00929.24 CDK99293.1 - 1.1e-25 91.1 0.0 1.6e-25 90.6 0.0 1.2 1 0 0 1 1 1 1 Exonuclease PAS PF00989.25 CDK99293.1 - 1.1e-05 25.4 0.0 2.2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold DUF5051 PF16473.5 CDK99293.1 - 0.0001 22.3 0.0 0.00025 21.1 0.0 1.6 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like PAS_8 PF13188.7 CDK99293.1 - 0.03 14.3 0.0 0.1 12.7 0.0 2.0 1 0 0 1 1 1 0 PAS domain PAS_9 PF13426.7 CDK99293.1 - 0.096 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 PAS domain DNA_pol_A_exo1 PF01612.20 CDK99293.1 - 0.21 11.3 0.0 17 5.1 0.0 2.5 3 0 0 3 3 3 0 3'-5' exonuclease TMEM192 PF14802.6 CDK99293.1 - 0.79 8.8 2.2 1.7 7.7 2.1 1.5 1 1 0 1 1 1 0 TMEM192 family STAS_2 PF13466.6 CDK99294.1 - 2.5e-11 43.7 0.4 2.8e-11 43.6 0.4 1.0 1 0 0 1 1 1 1 STAS domain STAS PF01740.21 CDK99294.1 - 2.7e-07 30.2 0.0 2.9e-07 30.1 0.0 1.0 1 0 0 1 1 1 1 STAS domain SpoIIE PF07228.12 CDK99295.1 - 1.7e-29 103.1 0.0 3e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Response_reg PF00072.24 CDK99295.1 - 2.5e-28 98.5 0.1 4.8e-28 97.6 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c_2 PF13581.6 CDK99295.1 - 5.1e-06 26.5 0.2 3.4e-05 23.8 0.0 2.2 1 1 1 2 2 2 1 Histidine kinase-like ATPase domain MCPsignal PF00015.21 CDK99296.1 - 5.8e-38 130.4 40.8 3.1e-36 124.8 20.8 3.7 2 1 2 4 4 4 3 Methyl-accepting chemotaxis protein (MCP) signalling domain CZB PF13682.6 CDK99296.1 - 3e-12 46.8 1.3 6e-12 45.8 1.3 1.5 1 0 0 1 1 1 1 Chemoreceptor zinc-binding domain DUF3739 PF12545.8 CDK99296.1 - 0.019 15.4 3.5 0.06 13.8 3.5 1.8 1 0 0 1 1 1 0 Filamentous haemagglutinin family outer membrane protein DUF948 PF06103.11 CDK99296.1 - 0.035 14.4 26.6 0.067 13.5 4.7 4.8 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF664 PF04978.12 CDK99296.1 - 0.053 13.9 4.1 0.13 12.7 0.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF664) Transcrip_act PF04949.13 CDK99296.1 - 0.14 12.0 2.6 0.77 9.6 0.0 2.9 2 1 1 3 3 3 0 Transcriptional activator Arfaptin PF06456.13 CDK99296.1 - 1.9 8.0 6.9 11 5.5 1.1 3.2 1 1 2 3 3 3 0 Arfaptin-like domain TMPIT PF07851.13 CDK99296.1 - 3.3 6.9 7.5 9.2 5.4 1.1 2.7 1 1 2 3 3 3 0 TMPIT-like protein Fib_alpha PF08702.10 CDK99296.1 - 3.5 7.8 14.2 4.3 7.5 1.5 3.5 2 2 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 CDK99296.1 - 7.3 6.6 21.3 5.5 7.1 0.4 4.3 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) HemolysinCabind PF00353.19 CDK99297.1 - 4.9e-38 128.7 300.8 5.3e-07 29.5 8.3 27.7 26 3 2 28 28 28 13 RTX calcium-binding nonapeptide repeat (4 copies) FecR PF04773.13 CDK99297.1 - 1.6e-10 41.5 0.2 1.7e-09 38.1 0.2 3.0 2 0 0 2 2 2 1 FecR protein Pirin_C_2 PF17954.1 CDK99297.1 - 0.088 13.0 3.7 4.4 7.5 0.1 4.7 5 0 0 5 5 5 0 Quercetinase C-terminal cupin domain Cytochrom_C PF00034.21 CDK99298.1 - 7.2e-08 33.5 0.0 1.1e-07 32.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CDK99298.1 - 0.0059 16.9 0.0 0.034 14.5 0.0 2.1 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III SoxY PF13501.6 CDK99299.1 - 3.8e-37 126.9 0.1 4.9e-37 126.6 0.1 1.2 1 0 0 1 1 1 1 Sulfur oxidation protein SoxY TAT_signal PF10518.9 CDK99299.1 - 0.0025 17.6 3.7 0.0062 16.3 3.7 1.7 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence Desulfoferrodox PF01880.18 CDK99299.1 - 0.043 14.4 0.0 0.067 13.8 0.0 1.3 1 0 0 1 1 1 0 Desulfoferrodoxin PP2C_2 PF13672.6 CDK99299.1 - 0.074 12.7 0.1 0.15 11.7 0.0 1.6 2 0 0 2 2 2 0 Protein phosphatase 2C SoxZ PF08770.11 CDK99300.1 - 8.3e-32 108.8 0.1 9.6e-32 108.6 0.1 1.0 1 0 0 1 1 1 1 Sulphur oxidation protein SoxZ SoxY PF13501.6 CDK99300.1 - 0.13 12.5 0.1 0.57 10.4 0.1 1.8 1 1 0 1 1 1 0 Sulfur oxidation protein SoxY Cytochrome_C7 PF14522.6 CDK99301.1 - 0.00059 19.8 0.4 0.36 10.8 0.1 2.3 2 0 0 2 2 2 2 Cytochrome c7 and related cytochrome c Cytochrome_CBB3 PF13442.6 CDK99301.1 - 0.0021 18.3 1.4 0.13 12.6 0.3 2.5 2 0 0 2 2 2 1 Cytochrome C oxidase, cbb3-type, subunit III CCP_MauG PF03150.14 CDK99301.1 - 0.0026 18.4 0.0 0.14 12.8 0.0 2.3 2 0 0 2 2 2 1 Di-haem cytochrome c peroxidase Cytochrom_c3_2 PF14537.6 CDK99301.1 - 0.0042 17.5 0.3 1.2 9.6 0.1 2.3 2 0 0 2 2 2 2 Cytochrome c3 DUF1924 PF09086.11 CDK99301.1 - 0.0048 17.2 0.1 0.56 10.6 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1924) Cytochrom_C PF00034.21 CDK99301.1 - 0.072 14.2 3.6 0.31 12.2 0.4 2.7 3 0 0 3 3 3 0 Cytochrome c DUF3365 PF11845.8 CDK99301.1 - 0.09 13.1 0.1 1 9.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) 5_nucleotid_C PF02872.18 CDK99302.1 - 2.4e-14 53.8 0.0 1.1e-13 51.7 0.0 2.0 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain TAT_signal PF10518.9 CDK99302.1 - 0.0028 17.4 4.5 0.0065 16.3 4.5 1.7 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.9 CDK99302.1 - 0.15 11.4 1.3 0.39 10.1 1.3 1.6 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DsbD PF02683.15 CDK99303.1 - 4e-60 203.4 15.2 4.6e-60 203.2 15.2 1.0 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DUF2162 PF09930.9 CDK99303.1 - 0.0057 16.1 13.6 0.24 10.8 4.2 2.3 1 1 1 2 2 2 2 Predicted transporter (DUF2162) LysE PF01810.18 CDK99303.1 - 0.0074 15.8 19.0 0.0079 15.7 5.1 2.8 2 2 0 2 2 2 2 LysE type translocator DUF3379 PF11859.8 CDK99303.1 - 0.87 8.9 2.5 0.81 9.0 0.8 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3379) SBP_bac_8 PF13416.6 CDK99304.1 - 9.6e-18 65.0 0.0 1.6e-17 64.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 CDK99304.1 - 1.9e-16 60.2 0.0 4.9e-16 58.9 0.0 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CDK99304.1 - 3e-12 46.8 0.1 9.9e-12 45.1 0.1 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CDK99304.1 - 1e-09 38.8 0.8 0.00025 21.1 0.2 2.1 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein Phosphonate-bd PF12974.7 CDK99304.1 - 0.023 14.3 0.6 0.13 11.8 0.1 2.0 2 0 0 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein Thioredoxin_2 PF13098.6 CDK99305.1 - 3.1e-15 56.5 0.0 6.5e-15 55.5 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDK99305.1 - 2.9e-05 24.1 0.0 5.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_4 PF13462.6 CDK99305.1 - 0.015 15.5 0.0 4.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin Ribosomal_L9_N PF01281.19 CDK99305.1 - 0.017 14.6 0.0 0.036 13.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L9, N-terminal domain DUF5338 PF17273.2 CDK99305.1 - 0.1 12.6 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5338) DrsE PF02635.15 CDK99306.1 - 3.2e-13 50.1 0.0 3.8e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 DsrE/DsrF-like family DrsE_2 PF13686.6 CDK99306.1 - 0.0024 17.8 0.0 0.0029 17.5 0.0 1.2 1 0 0 1 1 1 1 DsrE/DsrF/DrsH-like family Na_H_Exchanger PF00999.21 CDK99308.1 - 9.3e-63 212.3 44.1 1.1e-62 212.0 44.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family KdgT PF03812.13 CDK99308.1 - 0.00027 20.4 6.3 0.00027 20.4 6.3 3.3 1 1 0 3 3 3 3 2-keto-3-deoxygluconate permease RNase_HII PF01351.18 CDK99309.1 - 6.6e-46 156.6 0.0 7.6e-46 156.5 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease HII EAL PF00563.20 CDK99310.1 - 1.3e-67 227.8 0.0 2.2e-67 227.1 0.0 1.4 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK99310.1 - 6.6e-51 172.2 0.0 1.2e-50 171.5 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain DUF3365 PF11845.8 CDK99310.1 - 3.1e-21 76.3 0.0 7.7e-21 75.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3365) PAS PF00989.25 CDK99310.1 - 7.9e-13 48.4 0.0 2e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDK99310.1 - 9.7e-13 48.3 0.0 1.8e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 CDK99310.1 - 3.1e-10 40.2 0.0 6.5e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK99310.1 - 5.3e-05 23.1 0.0 0.00024 21.0 0.0 2.2 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDK99310.1 - 0.00011 22.4 0.0 0.00031 21.0 0.0 1.9 1 0 0 1 1 1 1 PAS fold N6_N4_Mtase PF01555.18 CDK99311.1 - 1.6e-56 191.6 0.0 2e-56 191.3 0.0 1.1 1 0 0 1 1 1 1 DNA methylase RAMA PF18755.1 CDK99311.1 - 2.7e-15 56.7 0.0 5.3e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Restriction Enzyme Adenine Methylase Associated UPF0020 PF01170.18 CDK99311.1 - 0.0009 19.0 0.0 0.67 9.6 0.1 3.1 3 1 1 4 4 4 2 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.15 CDK99311.1 - 0.0035 17.0 0.0 0.2 11.2 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical protein 95 MethyltransfD12 PF02086.15 CDK99311.1 - 0.007 16.1 0.0 1.7 8.3 0.0 2.2 2 0 0 2 2 2 2 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_25 PF13649.6 CDK99311.1 - 0.01 16.5 0.0 0.26 12.0 0.0 2.8 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_11 PF08241.12 CDK99311.1 - 0.043 14.5 0.0 21 5.9 0.0 3.2 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_31 PF13847.6 CDK99311.1 - 0.11 12.3 0.0 1 9.2 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 CDK99311.1 - 0.22 11.1 0.0 3 7.3 0.0 2.5 3 0 0 3 3 3 0 Methyltransferase small domain PAD_porph PF04371.15 CDK99312.1 - 4.3e-26 91.9 0.0 1e-24 87.5 0.0 2.1 1 1 0 1 1 1 1 Porphyromonas-type peptidyl-arginine deiminase DAHP_synth_2 PF01474.16 CDK99314.1 - 2.4e-206 685.4 0.0 2.8e-206 685.2 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Methyltransf_25 PF13649.6 CDK99315.1 - 1.5e-09 38.4 0.0 2.4e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK99315.1 - 2.1e-08 34.7 0.0 3.1e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDK99315.1 - 9.8e-06 25.5 0.0 6.1e-05 22.9 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK99315.1 - 0.00053 20.7 0.0 0.00091 19.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 CDK99315.1 - 0.059 12.9 0.0 0.086 12.3 0.0 1.1 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Ubie_methyltran PF01209.18 CDK99315.1 - 0.23 10.8 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Nitroreductase PF00881.24 CDK99316.1 - 4.6e-26 91.9 0.0 6.7e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 CDK99316.1 - 0.14 11.7 0.0 7.2 6.1 0.0 2.1 2 0 0 2 2 2 0 Putative TM nitroreductase ChaC PF04752.12 CDK99317.1 - 2.6e-51 174.2 0.0 3e-51 174.0 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein GGACT PF06094.12 CDK99317.1 - 9.3e-07 29.5 0.1 1.3e-06 29.0 0.1 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like SBP_bac_3 PF00497.20 CDK99318.1 - 1.3e-36 126.2 0.0 1.9e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 HATPase_c PF02518.26 CDK99318.1 - 5.5e-24 84.8 0.0 1.1e-23 83.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_4 PF08448.10 CDK99318.1 - 2.6e-15 56.6 0.1 1.4e-14 54.3 0.0 2.3 2 0 0 2 2 2 1 PAS fold HisKA PF00512.25 CDK99318.1 - 2e-12 47.0 2.4 2.2e-11 43.6 0.1 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 CDK99318.1 - 0.00031 21.0 0.0 0.0015 18.8 0.0 2.2 2 0 0 2 2 2 1 PAS domain HATPase_c_5 PF14501.6 CDK99318.1 - 0.0038 17.1 0.0 0.0071 16.2 0.0 1.4 1 0 0 1 1 1 1 GHKL domain PAS PF00989.25 CDK99318.1 - 0.0049 16.8 0.0 0.015 15.3 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK99318.1 - 0.012 15.6 0.0 0.043 13.8 0.0 2.0 1 0 0 1 1 1 0 PAS domain dCache_2 PF08269.11 CDK99319.1 - 1.2e-64 218.3 0.0 1.7e-64 217.9 0.0 1.1 1 0 0 1 1 1 1 Cache domain sCache_2 PF17200.4 CDK99319.1 - 8e-41 139.5 0.0 3.8e-26 91.8 0.0 2.4 1 1 1 2 2 2 2 Single Cache domain 2 HATPase_c PF02518.26 CDK99319.1 - 7e-19 68.4 0.0 1.2e-17 64.4 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cache_3-Cache_2 PF17201.4 CDK99319.1 - 6.1e-15 55.3 0.0 4.6e-08 32.7 0.0 2.4 1 1 1 2 2 2 2 Cache 3/Cache 2 fusion domain HisKA PF00512.25 CDK99319.1 - 8e-10 38.6 0.8 3.6e-09 36.5 0.1 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Myc_target_1 PF15179.6 CDK99319.1 - 0.016 15.1 1.2 4.4 7.2 0.2 2.6 3 0 0 3 3 3 0 Myc target protein 1 HATPase_c_2 PF13581.6 CDK99319.1 - 0.029 14.3 0.0 0.069 13.1 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 CDK99319.1 - 0.16 11.9 0.0 0.9 9.5 0.0 2.2 1 1 0 1 1 1 0 GHKL domain MFS_1 PF07690.16 CDK99320.1 - 5.2e-28 98.0 52.0 2.3e-16 59.7 28.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sigma70_r2 PF04542.14 CDK99321.1 - 1e-15 57.2 0.1 1e-14 54.0 0.0 2.2 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CDK99321.1 - 1.8e-13 49.7 1.6 1.8e-13 49.7 1.6 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r3 PF04539.16 CDK99321.1 - 5.5e-05 23.2 0.7 0.0035 17.4 0.2 2.3 2 0 0 2 2 2 1 Sigma-70 region 3 HTH_3 PF01381.22 CDK99321.1 - 0.0066 16.5 0.2 1.6 8.8 0.1 2.5 2 0 0 2 2 2 1 Helix-turn-helix HTH_25 PF13413.6 CDK99321.1 - 0.058 13.3 1.3 0.32 10.9 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain GntR PF00392.21 CDK99321.1 - 0.064 12.9 0.5 0.19 11.4 0.5 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 CDK99321.1 - 0.12 12.3 0.5 0.29 11.1 0.5 1.6 1 0 0 1 1 1 0 HTH domain DUF2999 PF11212.8 CDK99321.1 - 0.21 11.9 0.0 7.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2999) HTH_31 PF13560.6 CDK99321.1 - 2.7 8.4 8.5 1.9 8.9 2.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain LysR_substrate PF03466.20 CDK99322.1 - 8.2e-51 172.3 8.5 1.2e-50 171.8 8.5 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDK99322.1 - 2.2e-21 75.6 2.1 2.2e-21 75.6 2.1 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CDK99322.1 - 0.0082 15.9 0.5 0.023 14.5 0.5 1.7 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain MarR_2 PF12802.7 CDK99322.1 - 0.17 11.8 2.9 0.19 11.7 0.9 2.2 2 0 0 2 2 2 0 MarR family HTH_20 PF12840.7 CDK99322.1 - 1.9 8.6 6.3 0.48 10.5 1.4 2.5 1 1 2 3 3 3 0 Helix-turn-helix domain MCPsignal PF00015.21 CDK99323.1 - 1.6e-14 54.1 1.0 2.4e-14 53.5 1.0 1.3 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CDK99323.1 - 1.1e-09 38.5 1.3 4.7e-09 36.4 1.2 1.9 1 1 0 1 1 1 1 Cache domain zf-dskA_traR PF01258.17 CDK99324.1 - 1e-11 44.6 0.4 1.5e-11 44.0 0.4 1.3 1 0 0 1 1 1 1 Prokaryotic dksA/traR C4-type zinc finger BssS PF13991.6 CDK99324.1 - 0.0036 17.3 0.1 0.0078 16.3 0.1 1.7 1 1 0 1 1 1 1 BssS protein family DUF1003 PF06210.11 CDK99324.1 - 0.88 9.7 2.7 0.55 10.4 0.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) FliX PF10768.9 CDK99325.1 - 8.4e-42 142.9 3.0 9.4e-42 142.8 3.0 1.0 1 0 0 1 1 1 1 Class II flagellar assembly regulator DDE_Tnp_IS66 PF03050.14 CDK99325.1 - 0.0094 15.5 0.0 0.012 15.1 0.0 1.1 1 0 0 1 1 1 1 Transposase IS66 family HD_5 PF13487.6 CDK99325.1 - 0.077 13.3 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 HD domain FlgI PF02119.16 CDK99326.1 - 6.1e-136 452.9 9.3 6.9e-136 452.7 9.3 1.0 1 0 0 1 1 1 1 Flagellar P-ring protein Kinesin_assoc PF16183.5 CDK99326.1 - 0.12 12.5 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Kinesin-associated Rod-binding PF10135.9 CDK99327.1 - 1.6e-13 51.0 3.1 5.2e-13 49.4 0.0 2.2 1 1 1 2 2 2 1 Rod binding protein FlgN PF05130.12 CDK99328.1 - 7.1e-07 29.8 1.9 7.4e-05 23.3 1.9 2.1 1 1 0 1 1 1 1 FlgN protein Flg_bbr_C PF06429.13 CDK99329.1 - 1.2e-10 41.4 1.1 1.2e-10 41.4 1.1 3.2 3 0 0 3 3 3 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CDK99329.1 - 1.6e-05 24.7 3.1 1.6e-05 24.7 3.1 2.9 3 0 0 3 3 3 1 Flagella basal body rod protein Flagellin_C PF00700.21 CDK99330.1 - 8.1e-10 38.9 0.8 8.1e-10 38.9 0.8 2.3 2 0 0 2 2 2 1 Bacterial flagellin C-terminal helical region Flg_bbr_C PF06429.13 CDK99330.1 - 0.037 14.2 0.2 0.2 11.8 0.1 2.4 2 0 0 2 2 2 0 Flagellar basal body rod FlgEFG protein C-terminal BLUF PF04940.12 CDK99331.1 - 7.6e-29 99.7 0.1 9.6e-29 99.4 0.1 1.1 1 0 0 1 1 1 1 Sensors of blue-light using FAD dDENN PF03455.19 CDK99331.1 - 0.1 12.6 0.1 0.36 10.9 0.0 1.8 2 0 0 2 2 2 0 dDENN domain Hist_deacetyl PF00850.19 CDK99332.1 - 4.5e-82 276.0 0.1 5.6e-82 275.7 0.1 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Hemerythrin PF01814.23 CDK99333.1 - 6.2e-12 46.3 1.1 7.6e-12 46.0 1.1 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain HTH_5 PF01022.20 CDK99334.1 - 6e-17 61.3 0.2 9.1e-17 60.7 0.2 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 CDK99334.1 - 6.9e-12 45.2 0.1 1.6e-11 44.1 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 CDK99334.1 - 0.00019 21.2 0.0 0.00035 20.4 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DprA_WH PF17782.1 CDK99334.1 - 0.0022 18.0 0.1 0.0053 16.8 0.1 1.6 1 0 0 1 1 1 1 DprA winged helix domain HTH_24 PF13412.6 CDK99334.1 - 0.0026 17.3 0.0 0.0059 16.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding PaaX PF07848.12 CDK99334.1 - 0.0029 17.8 0.1 0.0059 16.8 0.1 1.6 1 0 0 1 1 1 1 PaaX-like protein HTH_Crp_2 PF13545.6 CDK99334.1 - 0.0037 17.2 0.0 0.008 16.1 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain DUF742 PF05331.11 CDK99334.1 - 0.0052 16.6 0.2 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF742) MarR_2 PF12802.7 CDK99334.1 - 0.0064 16.4 0.3 0.016 15.1 0.3 1.7 1 1 0 1 1 1 1 MarR family HTH_23 PF13384.6 CDK99334.1 - 0.015 15.1 0.1 0.028 14.2 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain MarR PF01047.22 CDK99334.1 - 0.017 15.0 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 MarR family Rrf2 PF02082.20 CDK99334.1 - 0.022 15.1 0.0 0.038 14.3 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator DUF188 PF02639.14 CDK99334.1 - 0.032 13.9 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized BCR, YaiI/YqxD family COG1671 HTH_29 PF13551.6 CDK99334.1 - 0.056 13.5 0.2 0.084 12.9 0.2 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_27 PF13463.6 CDK99334.1 - 0.078 13.5 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain Fe_dep_repress PF01325.19 CDK99334.1 - 0.1 12.8 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain LMWPc PF01451.21 CDK99335.1 - 1.8e-19 70.5 0.0 2.1e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase LMWPc PF01451.21 CDK99336.1 - 1.7e-16 60.9 0.0 2.1e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase SBF PF01758.16 CDK99337.1 - 1.6e-34 119.3 17.1 1.6e-34 119.3 17.1 2.7 1 1 2 3 3 3 1 Sodium Bile acid symporter family ArsD PF06953.11 CDK99338.1 - 6.8e-46 155.6 0.1 7.5e-46 155.5 0.1 1.0 1 0 0 1 1 1 1 Arsenical resistance operon trans-acting repressor ArsD Thioredoxin_3 PF13192.6 CDK99338.1 - 0.038 14.0 0.0 0.057 13.5 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin domain ArsA_ATPase PF02374.15 CDK99339.1 - 3.6e-87 292.4 0.0 1.1e-47 162.7 0.0 4.1 2 2 1 3 3 3 3 Anion-transporting ATPase CbiA PF01656.23 CDK99339.1 - 2.6e-20 72.8 0.0 1.5e-09 38.0 0.0 2.5 2 1 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDK99339.1 - 1.8e-17 63.8 0.0 3.1e-10 40.2 0.0 2.6 2 1 0 2 2 2 2 AAA domain ParA PF10609.9 CDK99339.1 - 1e-10 41.5 5.0 4.1e-05 23.2 0.7 3.2 3 0 0 3 3 3 2 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 CDK99339.1 - 4.5e-10 39.4 0.2 5.6e-05 22.7 0.1 2.4 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family IstB_IS21 PF01695.17 CDK99339.1 - 4.4e-08 33.1 3.0 0.0059 16.4 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein CBP_BcsQ PF06564.12 CDK99339.1 - 5.7e-07 29.3 3.7 0.0029 17.1 0.1 2.7 3 0 0 3 3 2 2 Cellulose biosynthesis protein BcsQ AAA_16 PF13191.6 CDK99339.1 - 7.4e-07 29.7 5.8 2.2e-05 24.9 0.4 2.8 2 1 1 3 3 2 1 AAA ATPase domain MeaB PF03308.16 CDK99339.1 - 2.3e-06 26.8 4.3 0.0013 17.8 0.1 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB PhoH PF02562.16 CDK99339.1 - 3.3e-06 26.7 3.5 0.0064 16.0 0.1 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_25 PF13481.6 CDK99339.1 - 0.00018 21.2 9.2 0.039 13.5 2.8 3.3 2 1 0 2 2 2 2 AAA domain SRP54 PF00448.22 CDK99339.1 - 0.00056 19.6 7.3 0.025 14.2 1.7 3.3 3 1 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 CDK99339.1 - 0.0018 18.0 8.2 0.041 13.6 3.0 2.8 3 0 0 3 3 2 1 AAA domain APS_kinase PF01583.20 CDK99339.1 - 0.0067 16.3 1.0 4 7.3 0.1 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase RsgA_GTPase PF03193.16 CDK99339.1 - 0.0076 16.2 0.4 3.5 7.5 0.1 2.7 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 CDK99339.1 - 0.0077 16.3 0.1 0.16 12.1 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.29 CDK99339.1 - 0.0086 16.5 2.8 0.19 12.2 0.6 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CDK99339.1 - 0.016 14.6 4.0 0.033 13.6 1.6 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CDK99339.1 - 0.016 14.9 0.0 4.9 6.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain MipZ PF09140.11 CDK99339.1 - 0.021 14.1 8.3 0.22 10.8 3.6 3.1 3 1 0 3 3 2 0 ATPase MipZ AAA_22 PF13401.6 CDK99339.1 - 0.024 14.9 0.2 0.58 10.4 0.0 2.7 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDK99339.1 - 0.027 13.7 1.3 0.45 9.6 0.1 2.1 2 0 0 2 2 2 0 NB-ARC domain VirC1 PF07015.11 CDK99339.1 - 0.041 13.2 3.1 2.8 7.2 0.1 2.5 2 0 0 2 2 2 0 VirC1 protein RuvB_N PF05496.12 CDK99339.1 - 0.054 13.2 0.4 3.4 7.4 0.1 2.6 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Glyco_transf_4 PF13439.6 CDK99339.1 - 0.067 13.2 0.2 1.6 8.7 0.1 2.8 3 0 0 3 3 2 0 Glycosyltransferase Family 4 AdoHcyase_NAD PF00670.21 CDK99339.1 - 0.067 13.2 3.4 1.9 8.5 0.1 2.3 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain adh_short_C2 PF13561.6 CDK99339.1 - 0.09 12.3 2.5 0.14 11.7 1.0 2.0 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase ATP_bind_1 PF03029.17 CDK99339.1 - 0.09 12.5 2.1 4.2 7.1 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 CDK99339.1 - 0.12 12.3 3.9 1.8 8.5 0.6 2.8 2 0 0 2 2 2 0 NACHT domain Parvo_NS1 PF01057.17 CDK99339.1 - 0.12 11.4 0.1 0.21 10.7 0.1 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Roc PF08477.13 CDK99339.1 - 0.12 12.5 0.5 4 7.7 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Arabino_trans_N PF17689.1 CDK99339.1 - 0.13 12.4 0.4 1.8 8.7 0.0 2.5 2 0 0 2 2 2 0 Arabinosyltransferase concanavalin like domain PIF1 PF05970.14 CDK99339.1 - 0.13 11.4 0.2 10 5.1 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase CTP_synth_N PF06418.14 CDK99339.1 - 0.19 11.0 0.4 9.2 5.5 0.1 2.2 2 0 0 2 2 2 0 CTP synthase N-terminus Zeta_toxin PF06414.12 CDK99339.1 - 0.25 10.6 1.9 0.9 8.8 0.4 2.3 2 0 0 2 2 2 0 Zeta toxin DUF815 PF05673.13 CDK99339.1 - 0.26 10.4 0.2 4.1 6.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 CDK99339.1 - 0.27 11.0 3.3 9.5 6.0 0.9 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CDK99339.1 - 0.28 11.7 3.6 7.6 7.0 0.6 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CDK99339.1 - 0.3 10.6 0.4 11 5.5 0.1 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region LpxK PF02606.14 CDK99339.1 - 0.36 9.9 2.9 7.5 5.6 0.3 2.2 2 0 0 2 2 2 0 Tetraacyldisaccharide-1-P 4'-kinase NTPase_1 PF03266.15 CDK99339.1 - 0.46 10.4 1.4 20 5.0 0.2 2.5 2 0 0 2 2 2 0 NTPase ResIII PF04851.15 CDK99339.1 - 0.59 10.1 1.4 19 5.2 0.6 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit TIP49 PF06068.13 CDK99339.1 - 5 6.2 5.4 1.2 8.3 1.1 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain Glyco_trans_4_4 PF13579.6 CDK99339.1 - 5.1 7.5 15.8 0.54 10.7 5.4 3.3 2 2 0 3 3 3 0 Glycosyl transferase 4-like domain Transgly PF00912.22 CDK99340.1 - 4e-46 156.7 0.0 5.4e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 Transglycosylase HlyD_D23 PF16576.5 CDK99342.1 - 2.4e-19 69.4 5.7 6.6e-18 64.7 5.7 2.0 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CDK99342.1 - 4.9e-17 62.6 0.9 1.4e-13 51.4 0.0 2.6 2 1 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDK99342.1 - 1.8e-11 43.6 1.9 1.6e-09 37.4 0.2 3.7 4 0 0 4 4 4 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK99342.1 - 0.041 13.7 0.0 0.19 11.6 0.0 2.1 3 0 0 3 3 3 0 Biotin-requiring enzyme Lum_binding PF00677.17 CDK99342.1 - 0.076 13.0 0.0 0.23 11.5 0.0 1.9 2 1 0 2 2 2 0 Lumazine binding domain MacB_PCD PF12704.7 CDK99343.1 - 1.2e-10 42.1 1.8 3.2e-10 40.7 1.8 1.7 1 0 0 1 1 1 1 MacB-like periplasmic core domain FtsX PF02687.21 CDK99343.1 - 1.2e-05 25.7 5.2 1.2e-05 25.7 5.2 3.4 3 1 0 3 3 3 1 FtsX-like permease family ABC_tran PF00005.27 CDK99344.1 - 8.8e-32 110.5 0.0 1.1e-31 110.2 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK99344.1 - 2.1e-07 31.1 0.0 0.0036 17.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK99344.1 - 6e-07 29.1 0.6 0.00015 21.3 0.1 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDK99344.1 - 0.00026 21.4 0.1 0.0005 20.5 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDK99344.1 - 0.0011 18.7 0.1 0.0019 17.9 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CDK99344.1 - 0.0025 17.4 1.4 0.22 11.1 1.4 2.4 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CDK99344.1 - 0.0069 16.1 0.0 1.4 8.6 0.0 2.0 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CDK99344.1 - 0.01 15.8 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 CDK99344.1 - 0.011 15.5 1.6 0.088 12.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 CDK99344.1 - 0.012 14.7 0.0 0.024 13.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.6 CDK99344.1 - 0.019 15.5 0.0 0.23 12.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDK99344.1 - 0.05 13.8 1.0 0.27 11.4 1.0 2.1 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 CDK99344.1 - 0.067 12.4 0.3 0.21 10.8 0.1 1.6 1 1 0 2 2 2 0 KAP family P-loop domain PRK PF00485.18 CDK99344.1 - 0.069 12.9 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_22 PF13401.6 CDK99344.1 - 0.072 13.4 0.6 0.35 11.1 0.6 2.1 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 CDK99344.1 - 0.11 13.0 0.1 15 6.0 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 CDK99344.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase SbcCD_C PF13558.6 CDK99344.1 - 0.16 12.2 0.2 0.79 10.0 0.2 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 CDK99344.1 - 0.17 12.3 0.0 0.28 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain TetR_N PF00440.23 CDK99345.1 - 3.2e-09 36.4 0.0 5.1e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.6 CDK99345.1 - 1.1e-06 28.9 1.4 1.1e-06 28.9 1.4 1.8 2 0 0 2 2 2 1 BetI-type transcriptional repressor, C-terminal TetR_C_33 PF13305.6 CDK99345.1 - 8.6e-05 23.2 1.5 0.00083 20.1 0.9 2.1 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_C_24 PF17932.1 CDK99345.1 - 0.00087 19.5 0.0 0.0017 18.6 0.0 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain HTH_10 PF04967.12 CDK99345.1 - 0.025 14.4 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain MarR_2 PF12802.7 CDK99345.1 - 0.036 14.0 0.3 0.27 11.2 0.0 2.3 2 0 0 2 2 2 0 MarR family HTH_23 PF13384.6 CDK99345.1 - 0.083 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain Peptidase_C27 PF05407.12 CDK99345.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Rubella virus endopeptidase HTH_24 PF13412.6 CDK99345.1 - 0.15 11.7 0.0 0.35 10.5 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding SIS PF01380.22 CDK99346.1 - 1.2e-54 183.7 0.1 3.7e-30 104.5 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 CDK99346.1 - 2.8e-21 76.1 0.0 6.9e-21 74.9 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CDK99346.1 - 2e-15 56.8 0.0 3.8e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 CDK99346.1 - 0.0017 18.4 0.0 0.0044 17.0 0.0 1.7 1 0 0 1 1 1 1 SIS domain GATase_4 PF13230.6 CDK99346.1 - 0.14 11.1 0.0 0.25 10.2 0.0 1.3 1 0 0 1 1 1 0 Glutamine amidotransferases class-II Hexapep PF00132.24 CDK99347.1 - 2e-24 84.3 14.8 4.2e-08 32.6 0.6 4.8 2 1 2 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CDK99347.1 - 5.9e-21 75.5 1.0 9.4e-21 74.8 1.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 CDK99347.1 - 1.2e-11 44.7 0.0 1.6e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase IspD PF01128.19 CDK99347.1 - 5.5e-11 42.6 1.7 5.6e-10 39.3 1.1 2.1 2 0 0 2 2 2 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Hexapep_2 PF14602.6 CDK99347.1 - 9.9e-08 31.6 11.3 6.7e-07 28.9 0.3 4.5 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase CTP_transf_3 PF02348.19 CDK99347.1 - 4.8e-05 23.4 0.0 8.1e-05 22.6 0.0 1.3 1 1 0 1 1 1 1 Cytidylyltransferase CofC PF01983.16 CDK99347.1 - 0.002 17.4 0.0 0.003 16.8 0.0 1.2 1 0 0 1 1 1 1 Guanylyl transferase CofC like DUF4954 PF16314.5 CDK99347.1 - 0.59 8.2 1.4 0.99 7.5 0.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) HAD_2 PF13419.6 CDK99348.1 - 2.3e-35 122.3 0.0 2.6e-35 122.1 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDK99348.1 - 8e-25 88.4 0.5 7.4e-24 85.2 0.5 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDK99348.1 - 2e-11 44.7 0.2 3.8e-11 43.7 0.2 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDK99348.1 - 7.2e-09 35.6 0.2 2.3e-08 34.0 0.1 1.9 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_3 PF08282.12 CDK99348.1 - 2.4e-08 34.0 0.6 0.017 14.9 0.0 3.1 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDK99348.1 - 1.6e-05 24.9 0.0 0.00032 20.8 0.0 2.6 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase NIF PF03031.18 CDK99348.1 - 0.082 12.7 0.0 0.49 10.1 0.0 2.1 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase PNK3P PF08645.11 CDK99348.1 - 0.18 11.5 0.0 3.9 7.1 0.0 2.6 2 1 0 2 2 2 0 Polynucleotide kinase 3 phosphatase ABC-3 PF00950.17 CDK99349.1 - 3.3e-66 223.4 22.7 4e-66 223.2 22.7 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 CDK99349.1 - 2.7e-11 43.1 25.1 3.8e-11 42.6 25.1 1.2 1 0 0 1 1 1 1 FecCD transport family ABC_tran PF00005.27 CDK99350.1 - 2.7e-24 86.2 0.0 6.2e-24 85.1 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK99350.1 - 3.5e-08 33.6 0.1 0.007 16.2 0.2 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDK99350.1 - 9.2e-05 22.1 0.5 0.00017 21.2 0.5 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDK99350.1 - 0.0025 18.2 0.1 0.0047 17.3 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDK99350.1 - 0.0029 17.9 0.0 0.0062 16.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDK99350.1 - 0.022 14.5 1.2 0.049 13.4 1.2 1.5 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.19 CDK99350.1 - 0.024 14.0 0.2 0.16 11.4 0.1 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDK99350.1 - 0.039 13.9 0.3 0.064 13.2 0.3 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_23 PF13476.6 CDK99350.1 - 0.04 14.4 0.1 0.055 14.0 0.1 1.1 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 CDK99350.1 - 0.05 13.2 0.0 0.13 11.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CDK99350.1 - 0.13 12.2 1.0 1.6 8.6 0.5 2.1 2 0 0 2 2 2 0 NTPase AAA_33 PF13671.6 CDK99350.1 - 0.18 12.0 0.2 0.39 10.9 0.2 1.6 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 CDK99350.1 - 0.18 12.1 0.0 2.3 8.5 0.0 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Rad17 PF03215.15 CDK99350.1 - 0.2 11.5 0.1 0.38 10.7 0.1 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 CDK99350.1 - 0.31 10.9 0.1 0.48 10.3 0.1 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_15 PF13175.6 CDK99350.1 - 0.34 10.6 0.2 0.59 9.8 0.2 1.3 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 CDK99350.1 - 0.37 9.9 0.5 1.6 7.9 0.3 1.8 2 0 0 2 2 2 0 NB-ARC domain FUR PF01475.19 CDK99351.1 - 2.5e-09 37.3 0.0 4.8e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Ferric uptake regulator family HTH_39 PF14090.6 CDK99351.1 - 0.19 11.5 1.1 27 4.6 0.8 3.0 3 1 0 3 3 3 0 Helix-turn-helix domain ZnuA PF01297.17 CDK99352.1 - 2.5e-57 194.2 0.0 2.8e-57 194.1 0.0 1.0 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic PRA-CH PF01502.18 CDK99353.1 - 5.6e-36 122.2 0.4 8.5e-36 121.6 0.4 1.3 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase cobW PF02492.19 CDK99354.1 - 2.8e-48 163.8 0.0 3.9e-48 163.4 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 CDK99354.1 - 8.6e-19 67.3 0.0 2e-18 66.1 0.0 1.7 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 CDK99354.1 - 0.00049 20.1 0.0 0.39 10.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 CDK99354.1 - 0.025 14.8 0.6 0.077 13.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDK99354.1 - 0.028 14.6 0.1 0.069 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CDK99354.1 - 0.044 14.0 0.0 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDK99354.1 - 0.07 13.5 0.2 0.12 12.7 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain DAP3 PF10236.9 CDK99354.1 - 0.14 11.3 0.1 0.25 10.4 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_18 PF13238.6 CDK99354.1 - 0.15 12.6 0.0 0.43 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDK99354.1 - 0.16 12.0 0.1 0.16 12.0 0.1 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 CDK99354.1 - 0.17 11.6 0.1 0.35 10.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SBP_bac_8 PF13416.6 CDK99355.1 - 1.4e-28 100.5 0.0 1.8e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CDK99355.1 - 1.1e-19 71.6 0.2 1.7e-19 70.9 0.2 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Abhydrolase_1 PF00561.20 CDK99356.1 - 4.1e-20 72.5 0.4 5e-18 65.7 0.4 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDK99356.1 - 2.5e-19 70.8 9.4 2.8e-19 70.6 9.4 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDK99356.1 - 3.6e-07 29.7 0.7 5.9e-07 29.0 0.7 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CDK99356.1 - 3.9e-07 30.0 0.1 0.0016 18.2 0.0 2.3 2 0 0 2 2 2 2 PGAP1-like protein Esterase PF00756.20 CDK99356.1 - 8.8e-06 25.5 0.1 2.2e-05 24.3 0.1 1.8 1 1 0 1 1 1 1 Putative esterase Thioesterase PF00975.20 CDK99356.1 - 0.001 19.2 0.2 0.0015 18.7 0.2 1.2 1 0 0 1 1 1 1 Thioesterase domain DUF676 PF05057.14 CDK99356.1 - 0.033 13.7 0.0 0.084 12.4 0.0 1.6 1 1 0 1 1 1 0 Putative serine esterase (DUF676) Ser_hydrolase PF06821.13 CDK99356.1 - 0.035 14.0 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Chlorophyllase PF07224.11 CDK99356.1 - 0.04 12.9 0.1 0.061 12.3 0.1 1.2 1 0 0 1 1 1 0 Chlorophyllase Chlorophyllase2 PF12740.7 CDK99356.1 - 0.042 12.8 0.0 0.069 12.1 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF3141 PF11339.8 CDK99356.1 - 0.15 10.5 0.1 0.19 10.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) ABC_tran PF00005.27 CDK99357.1 - 2.2e-36 125.4 0.0 2.8e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK99357.1 - 7.2e-10 39.2 0.0 1.4e-06 28.3 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK99357.1 - 2.8e-08 33.5 0.3 2.7e-05 23.7 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 CDK99357.1 - 5.5e-05 23.0 0.0 0.00011 22.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDK99357.1 - 0.00013 21.7 0.0 0.00021 21.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDK99357.1 - 0.00023 21.6 0.0 0.00038 20.9 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CDK99357.1 - 0.0008 19.8 0.0 0.81 10.1 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDK99357.1 - 0.0021 18.3 0.1 0.0065 16.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CDK99357.1 - 0.0051 16.7 0.1 0.0088 16.0 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_15 PF13175.6 CDK99357.1 - 0.0064 16.2 0.0 2.5 7.7 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 CDK99357.1 - 0.0099 16.0 0.1 0.024 14.8 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CDK99357.1 - 0.017 14.6 0.1 0.029 13.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SbcCD_C PF13558.6 CDK99357.1 - 0.019 15.2 0.4 0.35 11.1 0.4 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Rad17 PF03215.15 CDK99357.1 - 0.029 14.3 0.0 0.05 13.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 CDK99357.1 - 0.031 14.8 0.0 0.052 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain MctB PF11382.8 CDK99357.1 - 0.036 13.8 0.1 0.68 9.6 0.0 2.2 2 1 0 2 2 2 0 Copper transport outer membrane protein, MctB T2SSE PF00437.20 CDK99357.1 - 0.041 12.9 0.0 0.082 12.0 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 CDK99357.1 - 0.044 14.3 0.0 0.072 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDK99357.1 - 0.052 12.7 0.0 0.075 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) cobW PF02492.19 CDK99357.1 - 0.061 12.9 0.1 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.21 CDK99357.1 - 0.062 12.7 0.0 0.37 10.1 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CDK99357.1 - 0.072 12.8 0.0 0.18 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CDK99357.1 - 0.089 13.1 0.0 0.12 12.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 CDK99357.1 - 0.094 12.5 0.0 0.13 12.0 0.0 1.3 1 1 0 1 1 1 0 DEAD/DEAH box helicase IstB_IS21 PF01695.17 CDK99357.1 - 0.11 12.2 0.0 0.25 11.0 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein ATPase_2 PF01637.18 CDK99357.1 - 0.12 12.3 0.1 0.29 11.0 0.1 1.7 2 1 0 2 2 1 0 ATPase domain predominantly from Archaea ATP_bind_1 PF03029.17 CDK99357.1 - 0.12 12.1 0.1 0.23 11.2 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein ABC_ATPase PF09818.9 CDK99357.1 - 0.13 11.0 0.0 1.5 7.6 0.0 2.3 2 1 0 2 2 2 0 Predicted ATPase of the ABC class RNA_helicase PF00910.22 CDK99357.1 - 0.15 12.5 0.0 0.36 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 CDK99357.1 - 0.16 12.2 0.0 0.33 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Peptidase_C30 PF05409.13 CDK99357.1 - 0.17 11.2 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Coronavirus endopeptidase C30 G-alpha PF00503.20 CDK99357.1 - 0.27 10.4 0.0 0.38 9.9 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit BPD_transp_1 PF00528.22 CDK99358.1 - 3.6e-23 82.3 6.0 3.6e-23 82.3 6.0 2.9 2 1 1 3 3 3 2 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 CDK99359.1 - 2e-17 63.5 20.0 2e-14 53.7 19.7 2.7 1 1 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_3 PF00497.20 CDK99360.1 - 7.9e-30 104.0 0.0 1.1e-29 103.4 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1 PF09084.11 CDK99360.1 - 0.002 18.1 0.0 0.025 14.5 0.0 2.1 1 1 1 2 2 2 1 NMT1/THI5 like ETC_C1_NDUFA4 PF04800.12 CDK99363.1 - 1.9e-33 114.6 0.1 2.1e-33 114.4 0.1 1.0 1 0 0 1 1 1 1 ETC complex I subunit conserved region NAD_binding_11 PF14833.6 CDK99363.1 - 0.074 13.3 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF2188 PF09954.9 CDK99363.1 - 0.12 12.6 0.6 0.3 11.2 0.6 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2188) HATPase_c PF02518.26 CDK99364.1 - 4.9e-10 39.9 0.0 8.9e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 2CSK_N PF08521.10 CDK99364.1 - 2.5e-05 24.4 0.0 5.4e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Two-component sensor kinase N-terminal HATPase_c_2 PF13581.6 CDK99364.1 - 0.00038 20.4 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HAMP PF00672.25 CDK99364.1 - 0.013 15.8 0.2 0.063 13.7 0.2 2.2 1 0 0 1 1 1 0 HAMP domain HATPase_c_5 PF14501.6 CDK99364.1 - 0.06 13.3 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 GHKL domain Trans_reg_C PF00486.28 CDK99365.1 - 8.2e-28 96.3 0.1 1.1e-26 92.7 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 CDK99365.1 - 1.7e-25 89.4 0.0 2.6e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain GATase_6 PF13522.6 CDK99365.1 - 0.00099 19.3 0.0 0.0019 18.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain PepSY PF03413.19 CDK99366.1 - 4.5e-12 46.3 0.0 5.6e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain PepSY_2 PF13670.6 CDK99366.1 - 6.5e-09 35.7 0.0 9.2e-09 35.2 0.0 1.2 1 1 0 1 1 1 1 Peptidase propeptide and YPEB domain Ni_hydr_CYTB PF01292.20 CDK99367.1 - 0.0002 21.0 14.1 0.0018 17.9 14.1 2.2 1 1 0 1 1 1 1 Prokaryotic cytochrome b561 Phage_holin_3_6 PF07332.11 CDK99367.1 - 0.0038 17.2 2.9 0.0038 17.2 2.9 2.1 2 0 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III DUF1924 PF09086.11 CDK99368.1 - 8.7e-39 131.8 0.3 1.1e-38 131.5 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1924) DHC PF09626.10 CDK99369.1 - 3.3e-36 124.7 0.0 3.8e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 Dihaem cytochrome c GSu_C4xC__C2xCH PF09698.10 CDK99369.1 - 0.017 15.9 0.3 7.5 7.4 0.0 2.4 2 0 0 2 2 2 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) Cytochrome_C7 PF14522.6 CDK99369.1 - 0.041 13.9 0.0 8.6 6.4 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CDK99369.1 - 0.052 13.3 0.9 2 8.2 0.0 2.3 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_CBB3 PF13442.6 CDK99369.1 - 0.052 13.9 1.7 11 6.5 0.5 2.9 2 1 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_NNT PF03264.14 CDK99369.1 - 0.098 12.3 0.0 2.7 7.7 0.0 2.1 2 0 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region DUF192 PF02643.15 CDK99370.1 - 9.5e-31 105.8 0.0 1.2e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 DUF4138 PF13595.6 CDK99370.1 - 0.074 12.3 0.0 0.092 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4138) CitMHS PF03600.16 CDK99371.1 - 1.6e-55 188.5 38.7 1.6e-55 188.5 38.7 1.9 1 1 0 2 2 2 1 Citrate transporter ArsB PF02040.15 CDK99371.1 - 7.1e-15 55.3 27.8 9e-15 54.9 27.8 1.0 1 0 0 1 1 1 1 Arsenical pump membrane protein CBS PF00571.28 CDK99372.1 - 2.5e-18 66.3 0.1 2.5e-08 34.2 0.0 2.3 2 0 0 2 2 2 2 CBS domain Na_H_antiport_1 PF06965.12 CDK99373.1 - 1.6e-141 471.5 27.2 1.8e-141 471.3 27.2 1.0 1 0 0 1 1 1 1 Na+/H+ antiporter 1 Response_reg PF00072.24 CDK99374.1 - 5.6e-29 100.6 0.0 9.9e-29 99.8 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 CDK99374.1 - 5.1e-19 67.6 0.2 7.6e-19 67.0 0.2 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDK99374.1 - 0.00075 19.1 0.1 0.0015 18.1 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 FleQ PF06490.11 CDK99374.1 - 0.004 17.5 0.0 0.006 16.9 0.0 1.3 1 0 0 1 1 1 1 Flagellar regulatory protein FleQ HTH_23 PF13384.6 CDK99374.1 - 0.0069 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4 PF04545.16 CDK99374.1 - 0.083 12.4 0.1 0.24 10.9 0.1 1.8 1 1 0 1 1 1 0 Sigma-70, region 4 HATPase_c PF02518.26 CDK99375.1 - 4.3e-18 65.9 0.0 1.1e-17 64.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 CDK99375.1 - 3.1e-17 62.6 0.0 7.2e-17 61.4 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDK99375.1 - 1.8e-13 50.7 0.3 1.8e-12 47.5 0.1 2.4 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CDK99375.1 - 2.9e-12 46.7 0.0 8.1e-12 45.3 0.0 1.8 1 0 0 1 1 1 1 PAS domain HisKA PF00512.25 CDK99375.1 - 1.8e-10 40.7 0.0 6.5e-10 38.9 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 CDK99375.1 - 7.7e-08 32.5 0.0 2.1e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK99375.1 - 2.4e-06 27.4 0.0 9.7e-06 25.5 0.0 2.0 1 0 0 1 1 1 1 PAS domain HATPase_c_5 PF14501.6 CDK99375.1 - 1.2e-05 25.1 0.0 2.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 GHKL domain CHASE PF03924.13 CDK99375.1 - 0.00071 19.6 0.1 0.0029 17.6 0.0 2.1 1 1 0 1 1 1 1 CHASE domain dCache_1 PF02743.18 CDK99375.1 - 0.0041 17.0 0.0 0.0093 15.8 0.0 1.5 1 0 0 1 1 1 1 Cache domain PAS_7 PF12860.7 CDK99375.1 - 0.13 12.4 0.1 7.6 6.7 0.0 2.9 2 1 1 3 3 3 0 PAS fold DUF4381 PF14316.6 CDK99375.1 - 2.2 8.5 8.0 10 6.3 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) DctP PF03480.13 CDK99376.1 - 9.4e-110 366.4 0.9 1.1e-109 366.2 0.9 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein, family 7 DUF4831 PF16115.5 CDK99376.1 - 0.033 13.2 0.1 0.059 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4831) Protamine_like PF06382.11 CDK99376.1 - 0.16 12.2 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Protamine and protamine like DctQ PF04290.12 CDK99377.1 - 3.7e-20 72.2 14.3 4.6e-20 71.9 12.2 2.1 1 1 1 2 2 2 1 Tripartite ATP-independent periplasmic transporters, DctQ component DUF2798 PF11391.8 CDK99377.1 - 0.11 12.5 5.2 0.28 11.2 5.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2798) DUF3341 PF11821.8 CDK99377.1 - 0.55 9.8 6.1 0.5 10.0 4.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3341) DctM PF06808.12 CDK99378.1 - 4e-132 441.0 56.3 4.6e-132 440.8 56.3 1.0 1 0 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component CitMHS PF03600.16 CDK99378.1 - 6.4 5.9 65.5 13 4.9 31.6 2.5 1 1 1 2 2 2 0 Citrate transporter NMT1_3 PF16868.5 CDK99379.1 - 1.8e-96 323.0 1.7 2e-96 322.8 1.7 1.0 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 CDK99379.1 - 9.4e-09 35.5 0.2 9.6e-08 32.2 0.1 2.1 2 0 0 2 2 2 1 NMT1/THI5 like Phosphonate-bd PF12974.7 CDK99379.1 - 5.3e-07 29.5 0.1 1.1e-06 28.4 0.1 1.7 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 CDK99379.1 - 0.0035 16.8 0.1 0.012 15.1 0.1 1.7 1 1 1 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 DctM PF06808.12 CDK99380.1 - 4e-85 286.2 56.0 1.1e-82 278.1 56.0 2.3 1 1 0 1 1 1 1 Tripartite ATP-independent periplasmic transporter, DctM component YjbE PF11106.8 CDK99380.1 - 0.48 10.7 8.9 0.048 13.9 3.0 2.5 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE DUF1850 PF08905.11 CDK99381.1 - 2.3e-25 88.8 0.0 2.7e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1850) Cofac_haem_bdg PF04187.13 CDK99382.1 - 1.1e-47 162.8 2.7 1.4e-47 162.5 2.7 1.1 1 0 0 1 1 1 1 Haem-binding uptake, Tiki superfamily, ChaN DUF2336 PF10098.9 CDK99384.1 - 6.7e-84 281.4 21.4 5.2e-82 275.3 8.8 2.1 2 0 0 2 2 2 2 Uncharacterised protein conserved in bacteria (DUF2336) DUF2064 PF09837.9 CDK99384.1 - 0.012 15.4 0.4 0.043 13.6 0.3 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) GATase PF00117.28 CDK99385.1 - 8.4e-13 48.5 0.0 1.1e-12 48.1 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CDK99385.1 - 0.00078 19.2 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 STb_secrete PF09075.10 CDK99385.1 - 0.029 14.4 0.2 0.064 13.3 0.2 1.6 1 0 0 1 1 1 0 Heat-stable enterotoxin B, secretory DJ-1_PfpI PF01965.24 CDK99385.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family ABC_tran PF00005.27 CDK99386.1 - 3.1e-31 108.7 0.0 4e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDK99386.1 - 4e-18 66.3 0.2 3.5e-08 33.6 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDK99386.1 - 0.0002 22.0 0.0 0.00028 21.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDK99386.1 - 0.00029 21.3 0.1 0.00052 20.4 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 CDK99386.1 - 0.003 17.3 0.1 0.007 16.1 0.1 1.7 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDK99386.1 - 0.0038 16.7 0.1 1.1 8.7 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 CDK99386.1 - 0.0043 16.4 0.0 0.0071 15.6 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin RsgA_GTPase PF03193.16 CDK99386.1 - 0.0069 16.3 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CDK99386.1 - 0.0082 15.9 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CDK99386.1 - 0.016 14.8 0.1 0.054 13.1 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CDK99386.1 - 0.018 14.8 0.0 0.039 13.6 0.0 1.4 2 0 0 2 2 2 0 AAA ATPase domain DUF3584 PF12128.8 CDK99386.1 - 0.027 12.0 0.2 0.035 11.6 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_27 PF13514.6 CDK99386.1 - 0.038 13.6 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDK99386.1 - 0.039 14.2 0.3 0.096 12.9 0.3 1.6 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 CDK99386.1 - 0.04 13.6 0.0 0.063 12.9 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_22 PF13401.6 CDK99386.1 - 0.044 14.1 0.2 0.39 11.0 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDK99386.1 - 0.069 13.3 0.1 0.16 12.1 0.1 1.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CDK99386.1 - 0.071 13.0 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 CDK99386.1 - 0.079 13.0 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 CDK99386.1 - 0.081 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_ATPase PF09818.9 CDK99386.1 - 0.12 11.1 0.0 2.8 6.7 0.1 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class MCM PF00493.23 CDK99386.1 - 0.16 11.0 0.1 3.4 6.7 0.0 2.1 2 0 0 2 2 2 0 MCM P-loop domain AAA_13 PF13166.6 CDK99386.1 - 0.19 10.3 0.0 0.23 10.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDK99387.1 - 1.2e-28 100.4 0.0 1.6e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter BCA_ABC_TP_C PF12399.8 CDK99387.1 - 2.8e-11 43.0 0.3 5.2e-11 42.2 0.3 1.5 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_21 PF13304.6 CDK99387.1 - 2.6e-07 30.7 0.5 0.00085 19.2 0.2 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDK99387.1 - 5.7e-05 23.7 0.3 7.4e-05 23.3 0.3 1.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDK99387.1 - 0.0013 18.5 0.4 0.0095 15.7 0.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDK99387.1 - 0.0018 18.0 0.2 0.0018 18.0 0.2 1.9 2 1 0 2 2 2 1 P-loop containing region of AAA domain AAA_27 PF13514.6 CDK99387.1 - 0.0033 17.0 0.1 0.0056 16.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDK99387.1 - 0.0063 16.0 0.3 0.22 11.0 0.1 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CDK99387.1 - 0.011 15.8 0.0 0.05 13.7 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDK99387.1 - 0.015 15.2 0.1 0.038 13.9 0.1 1.6 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 CDK99387.1 - 0.059 13.7 0.4 0.78 10.0 0.1 2.3 2 1 0 2 2 2 0 AAA domain KdpD PF02702.17 CDK99387.1 - 0.096 12.2 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain AAA PF00004.29 CDK99387.1 - 0.13 12.6 0.0 0.74 10.3 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 CDK99387.1 - 0.17 11.6 0.0 0.58 9.8 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain BPD_transp_2 PF02653.16 CDK99388.1 - 7.1e-43 146.7 32.2 7.1e-43 146.7 32.2 1.4 1 1 1 2 2 2 1 Branched-chain amino acid transport system / permease component PDR_assoc PF08370.11 CDK99388.1 - 0.023 14.5 1.4 0.42 10.4 0.1 2.6 2 0 0 2 2 2 0 Plant PDR ABC transporter associated ATP19 PF11022.8 CDK99388.1 - 0.025 14.9 1.6 0.64 10.4 0.1 2.9 2 0 0 2 2 2 0 ATP synthase subunit K TNFR_16_TM PF18422.1 CDK99388.1 - 2.4 8.2 4.7 94 3.1 0.0 3.7 3 0 0 3 3 3 0 Tumor necrosis factor receptor member 16 trans-membrane domain BPD_transp_2 PF02653.16 CDK99389.1 - 2.1e-38 132.1 46.4 2.4e-38 131.9 46.4 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component Peripla_BP_6 PF13458.6 CDK99390.1 - 1.6e-67 228.7 5.8 1.9e-67 228.4 5.8 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Peripla_BP_5 PF13433.6 CDK99390.1 - 4e-20 72.1 0.2 4.1e-13 49.1 0.0 2.2 2 0 0 2 2 2 2 Periplasmic binding protein domain ANF_receptor PF01094.28 CDK99390.1 - 1.1e-17 64.2 0.0 1.4e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Ribosomal_S11 PF00411.19 CDK99390.1 - 0.05 14.0 0.3 0.36 11.2 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein S11 ABC_sub_bind PF04392.12 CDK99390.1 - 0.054 12.7 0.3 0.18 11.0 0.0 1.9 2 0 0 2 2 2 0 ABC transporter substrate binding protein IPT PF01745.16 CDK99390.1 - 0.14 11.5 0.1 0.24 10.8 0.1 1.3 1 0 0 1 1 1 0 Isopentenyl transferase MCPsignal PF00015.21 CDK99391.1 - 1.1e-31 109.9 25.6 1.1e-31 109.9 25.6 2.7 1 1 1 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 CDK99391.1 - 1.6e-24 87.1 0.0 1.6e-24 87.1 0.0 2.9 3 1 0 3 3 3 1 Cache domain HAMP PF00672.25 CDK99391.1 - 4.1e-06 27.1 0.0 4.1e-06 27.1 0.0 3.9 4 0 0 4 4 4 1 HAMP domain DUF948 PF06103.11 CDK99391.1 - 0.0057 16.9 21.5 1.2 9.5 2.1 4.9 1 1 3 4 4 4 3 Bacterial protein of unknown function (DUF948) sCache_3_3 PF17202.4 CDK99391.1 - 0.013 15.9 2.5 3.4 8.1 0.0 4.1 4 0 0 4 4 4 0 Single cache domain 3 DUF1664 PF07889.12 CDK99391.1 - 0.046 13.8 13.9 0.78 9.8 0.4 4.1 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Prominin PF05478.11 CDK99391.1 - 0.074 11.0 6.5 3.1 5.6 4.3 2.2 1 1 1 2 2 2 0 Prominin Cas_Cas1 PF01867.16 CDK99391.1 - 1.8 7.7 7.6 0.14 11.2 2.3 1.8 2 0 0 2 2 2 0 CRISPR associated protein Cas1 TACC_C PF05010.14 CDK99391.1 - 3.3 7.4 7.3 0.21 11.3 0.4 2.2 2 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Laminin_II PF06009.12 CDK99391.1 - 5.9 6.9 24.5 0.47 10.5 1.8 4.4 3 2 2 5 5 5 0 Laminin Domain II EAL PF00563.20 CDK99392.1 - 3.1e-59 200.4 0.0 4.7e-59 199.8 0.0 1.3 1 0 0 1 1 1 1 EAL domain PAS PF00989.25 CDK99392.1 - 0.00016 21.7 0.0 0.00033 20.6 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 CDK99392.1 - 0.013 15.8 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 PAS fold PAS_9 PF13426.7 CDK99392.1 - 0.017 15.4 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 CDK99392.1 - 0.14 12.5 0.0 0.37 11.1 0.0 1.7 1 0 0 1 1 1 0 PAS fold DNA_ligase_aden PF01653.18 CDK99393.1 - 1.4e-112 375.9 0.0 1.9e-112 375.5 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent DNA ligase adenylation domain DNA_ligase_OB PF03120.16 CDK99393.1 - 2.7e-33 113.7 3.7 6.1e-33 112.6 3.7 1.6 1 0 0 1 1 1 1 NAD-dependent DNA ligase OB-fold domain HHH_2 PF12826.7 CDK99393.1 - 1e-15 57.6 0.4 1.1e-14 54.3 0.4 2.4 1 1 0 1 1 1 1 Helix-hairpin-helix motif BRCT PF00533.26 CDK99393.1 - 4.2e-12 46.3 0.0 7.5e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DNA_ligase_ZBD PF03119.16 CDK99393.1 - 5.2e-11 42.4 3.7 1.1e-10 41.3 3.7 1.6 1 0 0 1 1 1 1 NAD-dependent DNA ligase C4 zinc finger domain HHH_5 PF14520.6 CDK99393.1 - 0.00027 21.5 0.0 0.22 12.1 0.0 3.5 2 1 1 3 3 3 2 Helix-hairpin-helix domain HHH PF00633.23 CDK99393.1 - 0.0037 17.0 0.0 0.044 13.7 0.0 2.8 3 0 0 3 3 3 1 Helix-hairpin-helix motif PTCB-BRCT PF12738.7 CDK99393.1 - 0.013 15.4 0.1 0.026 14.4 0.1 1.5 1 0 0 1 1 1 0 twin BRCT domain TPR_10 PF13374.6 CDK99394.1 - 5e-06 26.2 6.2 0.15 12.0 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDK99394.1 - 0.039 14.2 8.4 3.8 7.9 0.2 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat Phasin_2 PF09361.10 CDK99394.1 - 0.27 11.5 2.4 1.8 8.9 0.1 2.9 3 0 0 3 3 3 0 Phasin protein DEAD PF00270.29 CDK99395.1 - 3.6e-46 157.1 0.0 1.1e-45 155.6 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDK99395.1 - 8.6e-30 103.3 0.1 2.5e-29 101.9 0.1 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain NACHT PF05729.12 CDK99395.1 - 0.001 19.0 0.0 0.0037 17.2 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 CDK99395.1 - 0.0016 18.8 0.2 0.17 12.2 0.0 2.4 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 CDK99395.1 - 0.0042 17.1 0.0 0.0078 16.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HEM4 PF02602.15 CDK99395.1 - 0.017 14.5 0.2 0.03 13.7 0.2 1.3 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD ERCC3_RAD25_C PF16203.5 CDK99395.1 - 0.036 13.3 0.0 0.052 12.7 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase UTP25 PF06862.12 CDK99395.1 - 0.11 11.2 0.0 0.31 9.7 0.0 1.7 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Peripla_BP_6 PF13458.6 CDK99396.1 - 2.9e-46 158.7 1.9 3.6e-46 158.4 1.9 1.0 1 0 0 1 1 1 1 Periplasmic binding protein Peripla_BP_5 PF13433.6 CDK99396.1 - 1.6e-12 47.1 0.0 2.7e-12 46.4 0.0 1.3 1 1 0 1 1 1 1 Periplasmic binding protein domain ANF_receptor PF01094.28 CDK99396.1 - 0.0043 16.2 0.0 0.44 9.6 0.0 2.2 2 0 0 2 2 2 2 Receptor family ligand binding region LppC PF04348.13 CDK99396.1 - 0.061 12.1 0.1 0.082 11.7 0.1 1.1 1 0 0 1 1 1 0 LppC putative lipoprotein Tex_N PF09371.10 CDK99397.1 - 4.1e-73 244.9 0.8 6.2e-73 244.3 0.8 1.3 1 0 0 1 1 1 1 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 CDK99397.1 - 1.4e-51 174.2 0.0 2.8e-51 173.2 0.0 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain HHH_3 PF12836.7 CDK99397.1 - 4.9e-26 90.8 0.1 1.6e-25 89.1 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif S1 PF00575.23 CDK99397.1 - 1.3e-22 79.9 1.2 3e-22 78.7 1.2 1.7 1 0 0 1 1 1 1 S1 RNA binding domain HHH_9 PF17674.1 CDK99397.1 - 1.3e-22 80.4 0.0 5.1e-22 78.6 0.0 2.1 1 0 0 1 1 1 1 HHH domain HHH_7 PF14635.6 CDK99397.1 - 3.9e-07 30.4 0.0 8.3e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 CDK99397.1 - 9.8e-06 25.4 0.0 2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 T2SSK PF03934.13 CDK99397.1 - 0.0024 17.3 2.3 0.0077 15.7 0.1 2.6 3 0 0 3 3 3 1 Type II secretion system (T2SS), protein K HHH_6 PF14579.6 CDK99397.1 - 0.026 14.8 0.0 0.14 12.5 0.0 2.3 1 0 0 1 1 1 0 Helix-hairpin-helix motif PCB_OB PF17092.5 CDK99397.1 - 0.033 14.9 0.0 0.14 12.9 0.0 2.1 2 0 0 2 2 1 0 Penicillin-binding protein OB-like domain FAD_binding_4 PF01565.23 CDK99397.1 - 0.034 13.9 0.8 0.085 12.6 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain K_channel_TID PF07941.11 CDK99397.1 - 4.3 7.9 6.6 12 6.4 6.6 1.7 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Glyco_tranf_2_3 PF13641.6 CDK99398.1 - 6.6e-33 114.5 0.0 1.2e-32 113.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CDK99398.1 - 5.8e-28 97.8 0.0 1.1e-27 97.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 CDK99398.1 - 6.7e-21 75.1 3.5 6.7e-21 75.1 3.5 2.1 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 CDK99398.1 - 3.9e-09 36.2 0.0 7.6e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_hydro_17 PF00332.18 CDK99398.1 - 7.9e-09 35.5 0.0 3.6e-08 33.4 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 Cellulose_synt PF03552.14 CDK99398.1 - 0.005 15.4 0.9 0.005 15.4 0.9 1.9 2 0 0 2 2 2 1 Cellulose synthase Chitin_synth_2 PF03142.15 CDK99398.1 - 0.023 13.3 0.0 5.4 5.5 0.0 2.5 2 0 0 2 2 2 0 Chitin synthase Oxidored_q6 PF01058.22 CDK99399.1 - 7.1e-28 97.1 0.2 1.1e-27 96.4 0.2 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit NiFe_hyd_SSU_C PF14720.6 CDK99399.1 - 2.6e-19 69.4 5.1 2.6e-19 69.4 5.1 1.9 2 0 0 2 2 2 1 NiFe/NiFeSe hydrogenase small subunit C-terminal NiFeSe_Hases PF00374.19 CDK99400.1 - 6.6e-63 213.3 0.0 2.3e-41 142.3 0.0 3.2 2 1 0 2 2 2 2 Nickel-dependent hydrogenase FtsK_SpoIIIE PF01580.18 CDK99401.1 - 2.7e-60 203.8 0.5 5.7e-60 202.7 0.5 1.5 1 1 0 1 1 1 1 FtsK/SpoIIIE family FtsK_alpha PF17854.1 CDK99401.1 - 1.8e-26 92.2 0.1 3.8e-26 91.2 0.1 1.6 1 0 0 1 1 1 1 FtsK alpha domain FtsK_gamma PF09397.10 CDK99401.1 - 2.4e-25 88.1 0.1 5e-25 87.1 0.1 1.6 1 0 0 1 1 1 1 Ftsk gamma domain AAA_10 PF12846.7 CDK99401.1 - 1e-05 24.7 0.0 0.012 14.6 0.0 2.2 2 0 0 2 2 2 2 AAA-like domain DUF87 PF01935.17 CDK99401.1 - 0.00092 19.4 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 Helicase HerA, central domain TniB PF05621.11 CDK99401.1 - 0.0014 18.1 0.2 2.2 7.6 0.0 3.5 4 0 0 4 4 4 2 Bacterial TniB protein AAA_22 PF13401.6 CDK99401.1 - 0.0017 18.6 0.1 0.016 15.5 0.1 2.4 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 CDK99401.1 - 0.018 14.1 0.2 0.041 12.9 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 CDK99401.1 - 0.032 13.1 0.0 0.12 11.2 0.0 1.8 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RHSP PF07999.11 CDK99401.1 - 0.11 11.4 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Retrotransposon hot spot protein Spt5_N PF11942.8 CDK99401.1 - 2.1 9.4 10.9 0.23 12.5 5.1 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal PAS_5 PF07310.13 CDK99402.1 - 6.3e-12 45.4 0.0 7.7e-12 45.2 0.0 1.0 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDK99402.1 - 2.2e-05 24.7 0.0 3.3e-05 24.1 0.0 1.4 1 1 0 1 1 1 1 PAS fold DUF21 PF01595.20 CDK99403.1 - 9.4e-48 162.2 3.4 1.3e-47 161.7 3.4 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CorC_HlyC PF03471.17 CDK99403.1 - 1.7e-22 79.2 0.1 8.5e-22 77.0 0.0 2.2 1 1 1 2 2 2 1 Transporter associated domain CBS PF00571.28 CDK99403.1 - 4.4e-13 49.5 1.1 1.7e-07 31.6 0.2 2.8 2 0 0 2 2 2 2 CBS domain EF-hand_7 PF13499.6 CDK99404.1 - 0.0024 18.3 0.7 0.036 14.5 0.0 2.8 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 CDK99404.1 - 0.03 14.2 0.0 0.14 12.2 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain MctB PF11382.8 CDK99405.1 - 0.0067 16.2 0.1 0.0067 16.2 0.1 1.7 1 1 1 2 2 2 1 Copper transport outer membrane protein, MctB PepSY_2 PF13670.6 CDK99405.1 - 0.044 13.8 0.1 0.081 12.9 0.0 1.6 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain RR_TM4-6 PF06459.12 CDK99405.1 - 2 8.2 6.0 2.3 8.0 6.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM176 PF14851.6 CDK99405.1 - 4.7 6.9 14.4 0.061 13.0 0.6 1.9 1 1 1 2 2 2 0 FAM176 family Presenilin PF01080.17 CDK99405.1 - 5 5.8 9.4 5.7 5.6 9.4 1.1 1 0 0 1 1 1 0 Presenilin Oxidored_q6 PF01058.22 CDK99406.1 - 4.1e-35 120.5 0.5 7.4e-35 119.6 0.3 1.5 2 0 0 2 2 2 1 NADH ubiquinone oxidoreductase, 20 Kd subunit NiFe_hyd_SSU_C PF14720.6 CDK99406.1 - 7.6e-30 103.1 2.5 3.8e-29 100.9 1.3 2.2 2 0 0 2 2 2 1 NiFe/NiFeSe hydrogenase small subunit C-terminal TAT_signal PF10518.9 CDK99406.1 - 5.1e-05 22.9 1.3 5.1e-05 22.9 1.3 3.7 3 0 0 3 3 3 1 TAT (twin-arginine translocation) pathway signal sequence Fer4_11 PF13247.6 CDK99407.1 - 5.7e-24 84.1 11.3 5.7e-24 84.1 11.3 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDK99407.1 - 1.3e-17 64.1 34.0 3.8e-08 33.8 0.0 2.9 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDK99407.1 - 1e-11 44.8 24.3 6.5e-06 26.2 10.4 3.2 2 1 2 4 4 4 4 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDK99407.1 - 5.1e-10 39.0 33.0 4.4e-05 23.4 3.6 4.6 4 1 0 4 4 4 3 4Fe-4S binding domain Fer4_10 PF13237.6 CDK99407.1 - 6.3e-10 39.0 27.1 1.2e-05 25.3 12.2 3.4 2 1 1 3 3 3 3 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDK99407.1 - 2.4e-09 36.7 29.5 0.00015 21.7 2.2 4.4 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4 PF00037.27 CDK99407.1 - 6.5e-08 32.1 40.3 4.7e-05 23.0 3.8 5.1 6 0 0 6 6 6 4 4Fe-4S binding domain TAT_signal PF10518.9 CDK99407.1 - 1e-06 28.3 3.1 1e-06 28.3 3.1 2.0 2 0 0 2 2 2 1 TAT (twin-arginine translocation) pathway signal sequence Fer4_4 PF12800.7 CDK99407.1 - 2.5e-06 27.6 32.8 0.0033 17.8 2.6 4.5 4 1 0 4 4 4 3 4Fe-4S binding domain Fer4_3 PF12798.7 CDK99407.1 - 6.6e-05 23.6 43.0 0.085 13.8 3.6 4.3 4 0 0 4 4 4 3 4Fe-4S binding domain Fer4_16 PF13484.6 CDK99407.1 - 0.00029 21.7 30.1 0.55 11.2 1.7 4.7 1 1 2 4 4 4 3 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 CDK99407.1 - 0.0004 20.5 27.5 0.0057 16.7 12.5 3.7 4 1 1 5 5 4 3 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDK99407.1 - 0.0048 17.3 27.0 0.064 13.7 6.1 3.8 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDK99407.1 - 0.016 15.7 25.0 3.4 8.3 0.4 4.5 2 1 1 3 3 3 0 4Fe-4S dicluster domain UCR_Fe-S_N PF10399.9 CDK99407.1 - 0.051 12.9 3.1 0.12 11.7 3.1 1.6 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Fer4_15 PF13459.6 CDK99407.1 - 1.3 9.8 21.6 12 6.7 6.5 3.7 2 2 0 2 2 2 0 4Fe-4S single cluster domain Fer4_22 PF17179.4 CDK99407.1 - 1.4 9.8 19.0 2.6 8.9 0.3 4.1 3 1 1 4 4 4 0 4Fe-4S dicluster domain NrfD PF03916.14 CDK99408.1 - 1e-16 61.5 24.6 1e-16 61.5 24.6 1.6 2 0 0 2 2 2 1 Polysulphide reductase, NrfD NiFeSe_Hases PF00374.19 CDK99409.1 - 7.3e-210 698.1 0.0 8.3e-210 697.9 0.0 1.0 1 0 0 1 1 1 1 Nickel-dependent hydrogenase HycI PF01750.18 CDK99410.1 - 2.9e-28 98.3 0.0 3.4e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Hydrogenase maturation protease HupF_HypC PF01455.18 CDK99411.1 - 6.3e-19 67.9 0.3 7.1e-19 67.7 0.3 1.0 1 0 0 1 1 1 1 HupF/HypC family PipA PF07108.11 CDK99411.1 - 0.031 13.8 0.0 0.034 13.7 0.0 1.1 1 0 0 1 1 1 0 PipA protein NiFeSe_Hases PF00374.19 CDK99412.1 - 1.4e-17 63.8 0.0 2.7e-14 53.0 0.0 2.2 2 0 0 2 2 2 2 Nickel-dependent hydrogenase DUF4880 PF16220.5 CDK99412.1 - 0.045 13.6 0.1 0.16 11.9 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4880) HypA PF01155.19 CDK99413.1 - 2.7e-31 107.9 0.1 2.9e-31 107.8 0.1 1.0 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_9 PF14369.6 CDK99413.1 - 0.0051 17.0 0.3 0.011 15.9 0.3 1.6 1 0 0 1 1 1 1 zinc-ribbon zf-C3HC4_3 PF13920.6 CDK99413.1 - 0.011 15.6 0.2 0.018 14.9 0.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TetR_C_3 PF08362.11 CDK99413.1 - 0.18 11.7 0.0 0.21 11.5 0.0 1.1 1 0 0 1 1 1 0 YcdC-like protein, C-terminal region cobW PF02492.19 CDK99414.1 - 7.8e-38 129.8 0.0 1e-37 129.5 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 CDK99414.1 - 0.025 14.7 0.0 0.039 14.0 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 CDK99414.1 - 0.062 13.2 0.0 0.062 13.2 0.0 2.3 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Zip PF02535.22 CDK99414.1 - 0.091 12.0 1.6 0.11 11.7 1.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NACHT PF05729.12 CDK99414.1 - 0.092 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 CDK99414.1 - 0.18 12.2 0.0 0.3 11.5 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2796 PF10986.8 CDK99414.1 - 0.7 9.8 16.6 0.51 10.3 14.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) HypF_C PF17788.1 CDK99415.1 - 2.5e-26 92.3 1.6 4.7e-26 91.5 1.6 1.4 1 0 0 1 1 1 1 HypF Kae1-like domain Peptidase_M22 PF00814.25 CDK99415.1 - 2.5e-05 24.1 1.2 0.0023 17.7 0.6 2.1 2 0 0 2 2 2 2 Glycoprotease family AnmK PF03702.14 CDK99415.1 - 0.065 12.3 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Anhydro-N-acetylmuramic acid kinase HupF_HypC PF01455.18 CDK99416.1 - 6e-27 93.6 0.2 7e-27 93.4 0.2 1.1 1 0 0 1 1 1 1 HupF/HypC family HypD PF01924.16 CDK99417.1 - 2.3e-156 520.3 0.0 2.6e-156 520.1 0.0 1.0 1 0 0 1 1 1 1 Hydrogenase formation hypA family AIRS_C PF02769.22 CDK99418.1 - 2.1e-29 102.7 0.7 4e-29 101.8 0.7 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 CDK99418.1 - 2.5e-14 53.7 2.7 2.5e-14 53.7 2.7 2.4 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain ECH_1 PF00378.20 CDK99419.1 - 2.8e-15 56.3 0.0 4.5e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Formyl_trans_N PF00551.19 CDK99419.1 - 2.7e-08 33.8 0.0 4.4e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 CDK99419.1 - 3.6e-06 27.1 0.0 7.4e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Xol-1_GHMP-like PF09109.10 CDK99419.1 - 0.043 13.7 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 Switch protein XOL-1, GHMP-like HATPase_c PF02518.26 CDK99420.1 - 2.4e-21 76.3 0.0 5.3e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 CDK99420.1 - 5e-12 46.0 0.0 1.3e-11 44.7 0.0 1.8 1 0 0 1 1 1 1 PAS domain HisKA PF00512.25 CDK99420.1 - 3.8e-08 33.2 0.5 3.2e-07 30.3 0.0 2.8 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain 4HB_MCP_1 PF12729.7 CDK99420.1 - 1.7e-07 31.0 0.0 4e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Four helix bundle sensory module for signal transduction PAS PF00989.25 CDK99420.1 - 6.2e-07 29.4 0.2 3.7e-06 26.9 0.0 2.5 2 1 1 3 3 3 1 PAS fold HAMP PF00672.25 CDK99420.1 - 9.5e-07 29.1 0.1 3.3e-06 27.4 0.1 2.0 1 0 0 1 1 1 1 HAMP domain PAS_4 PF08448.10 CDK99420.1 - 6.1e-06 26.5 0.0 1.4e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK99420.1 - 0.00017 21.5 0.0 0.0015 18.5 0.0 2.6 2 0 0 2 2 2 1 PAS domain TarH PF02203.15 CDK99420.1 - 0.0014 18.5 1.3 0.0027 17.7 0.0 2.1 3 0 0 3 3 3 1 Tar ligand binding domain homologue PAS_3 PF08447.12 CDK99420.1 - 0.022 15.0 0.0 0.078 13.3 0.0 2.0 1 0 0 1 1 1 0 PAS fold DUF2000 PF09391.10 CDK99420.1 - 0.031 14.2 0.0 0.081 12.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) DDE_3 PF13358.6 CDK99421.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK99421.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDK99422.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK99422.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK99422.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK99422.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK99422.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK99422.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain MCPsignal PF00015.21 CDK99423.1 - 2.8e-30 105.4 27.8 2.8e-30 105.4 27.8 3.3 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK99423.1 - 5.9e-05 23.4 4.7 0.00014 22.2 0.0 4.1 4 0 0 4 4 4 1 HAMP domain DUF948 PF06103.11 CDK99423.1 - 0.0084 16.3 28.6 1.3 9.3 1.7 6.1 3 2 1 5 5 5 3 Bacterial protein of unknown function (DUF948) SNARE PF05739.19 CDK99423.1 - 0.17 11.9 2.9 12 6.0 0.2 3.5 2 0 0 2 2 2 0 SNARE domain DUF1664 PF07889.12 CDK99423.1 - 0.23 11.5 13.5 1.1 9.3 1.9 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 CDK99423.1 - 0.36 10.8 24.2 7.2 6.6 6.7 4.6 1 1 3 4 4 4 0 Laminin Domain II Fib_alpha PF08702.10 CDK99423.1 - 2.3 8.4 9.8 0.86 9.8 0.3 3.6 1 1 4 5 5 5 0 Fibrinogen alpha/beta chain family PilZ PF07238.14 CDK99424.1 - 0.028 14.8 0.3 0.054 13.8 0.3 1.6 1 1 0 1 1 1 0 PilZ domain Sigma54_activat PF00158.26 CDK99425.1 - 4e-67 225.1 0.0 6.6e-67 224.4 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CDK99425.1 - 1.4e-22 80.0 0.0 2.8e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Sigma54_activ_2 PF14532.6 CDK99425.1 - 1.5e-21 77.0 0.0 2e-20 73.3 0.0 2.6 2 1 0 2 2 2 1 Sigma-54 interaction domain HTH_8 PF02954.19 CDK99425.1 - 1.3e-11 44.1 0.6 1.3e-11 44.1 0.6 2.3 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CDK99425.1 - 2.6e-07 30.7 0.1 1.8e-06 28.0 0.0 2.4 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CDK99425.1 - 4.9e-05 23.8 0.0 0.00013 22.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CDK99425.1 - 0.006 16.0 0.0 2.5 7.4 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI HTH_50 PF18024.1 CDK99425.1 - 0.017 14.7 0.1 0.04 13.5 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain MCM PF00493.23 CDK99425.1 - 0.027 13.6 0.0 0.11 11.5 0.0 1.9 1 1 0 1 1 1 0 MCM P-loop domain AAA_2 PF07724.14 CDK99425.1 - 0.04 14.0 0.0 0.2 11.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) HTH_30 PF13556.6 CDK99425.1 - 0.1 12.4 0.2 0.4 10.5 0.2 2.0 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HATPase_c PF02518.26 CDK99426.1 - 2.6e-20 73.0 0.1 4.7e-20 72.2 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK99426.1 - 2.9e-19 68.8 1.2 2.1e-17 62.9 0.2 2.8 2 1 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 CDK99426.1 - 2.7e-09 37.3 0.0 6.4e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDK99426.1 - 1.7e-05 25.0 0.0 4.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 PAS domain HATPase_c_5 PF14501.6 CDK99426.1 - 8.7e-05 22.4 0.0 0.00021 21.1 0.0 1.6 1 0 0 1 1 1 1 GHKL domain PAS PF00989.25 CDK99426.1 - 0.0015 18.5 0.0 0.0049 16.9 0.0 1.9 1 1 0 1 1 1 1 PAS fold HATPase_c_2 PF13581.6 CDK99426.1 - 0.0026 17.7 0.0 0.0068 16.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain PAS_8 PF13188.7 CDK99426.1 - 0.008 16.2 0.0 0.019 15.0 0.0 1.7 1 0 0 1 1 1 1 PAS domain HATPase_c_3 PF13589.6 CDK99426.1 - 0.066 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S28e PF01200.18 CDK99426.1 - 0.085 12.9 0.3 6.5 6.8 0.0 3.3 3 0 0 3 3 3 0 Ribosomal protein S28e AFG1_ATPase PF03969.16 CDK99427.1 - 9.6e-119 396.5 0.0 1.3e-118 396.0 0.0 1.1 1 0 0 1 1 1 1 AFG1-like ATPase Bac_DnaA PF00308.18 CDK99427.1 - 0.0014 18.5 0.0 0.0083 16.0 0.0 1.9 2 0 0 2 2 2 1 Bacterial dnaA protein ABC_tran PF00005.27 CDK99427.1 - 0.05 14.1 0.0 2.6 8.5 0.0 2.2 1 1 1 2 2 2 0 ABC transporter AAA_16 PF13191.6 CDK99427.1 - 0.066 13.6 0.4 6.9 7.0 0.2 2.6 1 1 1 2 2 2 0 AAA ATPase domain IstB_IS21 PF01695.17 CDK99427.1 - 0.069 12.9 0.0 6.7 6.4 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_22 PF13401.6 CDK99427.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain DHH PF01368.20 CDK99428.1 - 0.061 13.6 1.6 0.17 12.1 1.5 2.0 1 1 0 1 1 1 0 DHH family DHHA1 PF02272.19 CDK99428.1 - 0.082 13.3 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 DHHA1 domain DUF2973 PF11189.8 CDK99429.1 - 0.088 12.9 0.0 0.27 11.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) Fer2_3 PF13085.6 CDK99430.1 - 1.5e-32 111.8 0.0 2.4e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.6 CDK99430.1 - 9.3e-10 38.8 23.6 6.8e-09 36.0 7.5 2.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDK99430.1 - 4e-09 36.9 3.9 4e-09 36.9 3.9 1.8 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDK99430.1 - 2.7e-06 27.4 18.8 6.3e-06 26.2 6.8 2.7 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer2 PF00111.27 CDK99430.1 - 0.0046 16.9 0.2 0.0046 16.9 0.2 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.6 CDK99430.1 - 0.03 14.5 7.6 0.03 14.5 7.6 2.7 2 1 1 3 3 3 0 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDK99430.1 - 0.97 10.4 9.9 3.3 8.7 1.6 3.0 3 0 0 3 3 3 0 4Fe-4S double cluster binding domain Fer4_7 PF12838.7 CDK99430.1 - 1.5 9.5 16.7 6.3 7.5 12.8 3.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain FAD_binding_2 PF00890.24 CDK99431.1 - 9.9e-126 420.2 4.5 1.3e-125 419.8 4.5 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CDK99431.1 - 3.3e-43 146.7 1.1 4.9e-43 146.2 1.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 CDK99431.1 - 0.0001 21.6 1.0 0.00066 19.0 1.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDK99431.1 - 0.0097 15.0 2.6 0.77 8.8 4.4 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 CDK99431.1 - 0.014 14.7 1.4 0.034 13.4 0.5 2.0 2 0 0 2 2 2 0 Thi4 family FAD_binding_3 PF01494.19 CDK99431.1 - 0.053 12.8 1.6 0.093 12.0 1.6 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 CDK99431.1 - 1.2 7.7 3.2 1.5 7.4 1.8 1.7 2 0 0 2 2 2 0 HI0933-like protein Sdh_cyt PF01127.22 CDK99432.1 - 2.2e-11 43.8 5.2 2.7e-11 43.6 5.2 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Sdh_cyt PF01127.22 CDK99433.1 - 2.4e-31 108.3 7.2 2.7e-31 108.1 7.2 1.0 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Fumarate_red_D PF02313.17 CDK99433.1 - 0.0032 17.5 2.8 0.0051 16.9 2.3 1.6 1 1 0 1 1 1 1 Fumarate reductase subunit D ABC2_membrane PF01061.24 CDK99434.1 - 0.0026 17.2 2.0 0.0034 16.8 2.0 1.1 1 0 0 1 1 1 1 ABC-2 type transporter DZR PF12773.7 CDK99435.1 - 0.0057 16.7 0.8 0.0093 16.0 0.8 1.4 1 0 0 1 1 1 1 Double zinc ribbon Nudix_N_2 PF14803.6 CDK99435.1 - 0.0058 16.5 2.9 0.019 14.9 2.9 1.8 1 1 0 1 1 1 1 Nudix N-terminal Auto_anti-p27 PF06677.12 CDK99435.1 - 0.023 14.8 1.0 0.042 14.0 0.4 1.7 1 1 1 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-dskA_traR PF01258.17 CDK99435.1 - 0.037 14.0 0.4 0.092 12.7 0.4 1.7 1 0 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger zf_Rg PF17915.1 CDK99435.1 - 0.049 13.0 0.4 0.079 12.4 0.4 1.3 1 0 0 1 1 1 0 Reverse gyrase zinc finger HypA PF01155.19 CDK99435.1 - 0.11 12.5 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA OrfB_Zn_ribbon PF07282.11 CDK99435.1 - 0.14 12.1 1.0 0.26 11.2 1.0 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF983 PF06170.12 CDK99435.1 - 0.39 11.2 1.9 0.76 10.2 1.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF983) Hemerythrin PF01814.23 CDK99436.1 - 3.8e-06 27.6 7.7 5.2e-06 27.1 7.7 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain AbiJ_NTD3 PF18860.1 CDK99436.1 - 0.024 14.1 1.7 0.032 13.8 1.7 1.1 1 0 0 1 1 1 0 AbiJ N-terminal domain 3 PXA PF02194.15 CDK99436.1 - 0.064 13.2 1.0 0.17 11.9 0.6 1.8 1 1 1 2 2 2 0 PXA domain MaoC_dehydratas PF01575.19 CDK99437.1 - 6e-14 51.7 0.1 6.5e-08 32.2 0.0 2.1 2 0 0 2 2 2 2 MaoC like domain MaoC_dehydrat_N PF13452.6 CDK99437.1 - 1.5e-05 25.2 0.0 2.6e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase HpcH_HpaI PF03328.14 CDK99438.1 - 1.7e-48 164.7 0.3 2.8e-48 164.0 0.0 1.5 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 CDK99438.1 - 1.6e-08 34.1 0.1 0.0057 15.9 0.1 2.7 2 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold PEP-utilizers_C PF02896.18 CDK99438.1 - 0.0038 16.4 0.1 0.006 15.7 0.1 1.3 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain Phos_pyr_kin PF08543.12 CDK99439.1 - 2.7e-11 43.3 0.0 3e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CDK99439.1 - 3.3e-07 29.9 0.2 6.7e-07 28.9 0.2 1.5 2 0 0 2 2 2 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 CDK99439.1 - 0.015 14.8 0.2 0.055 12.9 0.2 1.9 1 1 0 1 1 1 0 Carbohydrate kinase LysE PF01810.18 CDK99440.1 - 1.6e-25 89.7 12.0 1.9e-25 89.4 12.0 1.0 1 0 0 1 1 1 1 LysE type translocator MotA_ExbB PF01618.16 CDK99440.1 - 5.6 6.7 13.5 5.4 6.8 3.9 3.0 2 1 1 3 3 3 0 MotA/TolQ/ExbB proton channel family TraW_N PF12477.8 CDK99441.1 - 0.26 11.3 7.2 0.14 12.2 3.3 2.1 2 0 0 2 2 2 0 Sex factor F TraW protein N terminal QVR PF17064.5 CDK99442.1 - 0.074 13.3 0.2 0.1 12.8 0.2 1.3 1 1 0 1 1 1 0 Sleepless protein MCPsignal PF00015.21 CDK99443.1 - 1.1e-29 103.4 23.6 1.1e-29 103.4 23.6 3.3 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDK99443.1 - 1.6e-10 41.2 1.0 1.6e-10 41.2 1.0 5.0 4 1 0 4 4 4 1 HAMP domain GHL13 PF14883.6 CDK99443.1 - 0.087 11.9 2.6 0.2 10.7 2.6 1.6 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 GCN5L1 PF06320.13 CDK99443.1 - 0.13 12.4 14.1 0.64 10.2 5.3 3.5 2 2 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) GldM_N PF12081.8 CDK99443.1 - 0.17 11.9 9.0 20 5.2 0.0 3.5 1 1 0 3 3 3 0 GldM N-terminal domain DUF948 PF06103.11 CDK99443.1 - 0.53 10.6 24.0 1.4 9.2 0.4 5.8 2 1 3 5 5 5 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 CDK99443.1 - 1.6 7.6 10.4 2.3 7.0 5.5 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein Sec34 PF04136.15 CDK99443.1 - 4.3 7.2 6.2 3.6 7.5 0.0 3.6 3 2 1 4 4 4 0 Sec34-like family MaoC_dehydratas PF01575.19 CDK99444.1 - 8.3e-26 90.0 0.3 1e-25 89.7 0.3 1.1 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CDK99444.1 - 1.1e-06 28.8 0.0 1.6e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase 4HBT PF03061.22 CDK99444.1 - 0.011 16.1 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 0 Thioesterase superfamily Homoserine_dh PF00742.19 CDK99444.1 - 0.053 13.4 0.5 0.24 11.3 0.1 1.9 2 0 0 2 2 2 0 Homoserine dehydrogenase PolyA_pol PF01743.20 CDK99445.1 - 4.7e-29 101.4 0.1 8.2e-29 100.6 0.1 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CDK99445.1 - 1.1e-11 44.3 0.1 2.7e-11 43.1 0.1 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 CDK99445.1 - 0.027 14.5 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative DUF2415 PF10313.9 CDK99445.1 - 0.042 13.8 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) NUDIX PF00293.28 CDK99446.1 - 6.5e-15 55.3 0.0 1e-14 54.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain DUF1285 PF06938.11 CDK99447.1 - 5.6e-58 195.1 0.0 6.4e-58 194.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1285) AAA_3 PF07726.11 CDK99448.1 - 4.3e-58 194.8 0.0 7.4e-58 194.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 CDK99448.1 - 4.5e-12 45.6 3.0 1.2e-11 44.2 3.0 1.8 1 0 0 1 1 1 1 AAA lid domain AAA_5 PF07728.14 CDK99448.1 - 5.6e-12 45.8 0.0 9.9e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) MCM PF00493.23 CDK99448.1 - 8.9e-06 25.0 0.0 4.2e-05 22.7 0.0 1.8 1 1 0 1 1 1 1 MCM P-loop domain Mg_chelatase PF01078.21 CDK99448.1 - 0.00035 20.0 0.1 0.13 11.6 0.1 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDK99448.1 - 0.0027 17.4 0.0 0.0055 16.4 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain RuvB_N PF05496.12 CDK99448.1 - 0.0072 16.1 0.0 0.86 9.3 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 CDK99448.1 - 0.13 12.7 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF58 PF01882.18 CDK99449.1 - 6.3e-12 45.6 0.4 1.2e-11 44.7 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF58 DUF4159 PF13709.6 CDK99450.1 - 7.3e-47 159.4 0.0 1.2e-46 158.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4159) BatA PF07584.11 CDK99450.1 - 4e-16 59.1 11.4 4e-16 59.1 11.4 2.3 2 0 0 2 2 2 1 Aerotolerance regulator N-terminal GATase1_like PF07090.11 CDK99451.1 - 0.0033 16.9 0.0 0.0069 15.9 0.0 1.5 1 1 0 1 1 1 1 Putative glutamine amidotransferase DUF4131 PF13567.6 CDK99451.1 - 3.1 7.4 7.0 0.82 9.3 2.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Peptidase_M23 PF01551.22 CDK99452.1 - 1.1e-34 118.5 0.3 3e-34 117.1 0.3 1.8 1 0 0 1 1 1 1 Peptidase family M23 CLZ PF16526.5 CDK99452.1 - 0.66 10.4 7.4 0.68 10.3 1.7 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Bactofilin PF04519.13 CDK99453.1 - 7.7e-26 90.3 8.2 1.1e-25 89.7 8.2 1.2 1 0 0 1 1 1 1 Polymer-forming cytoskeletal Phage_spike PF18715.1 CDK99453.1 - 0.13 12.3 5.9 1.1 9.4 1.1 2.9 1 1 1 2 2 2 0 Phage spike trimer BRICHOS PF04089.14 CDK99454.1 - 0.12 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 BRICHOS domain TPR_1 PF00515.28 CDK99455.1 - 9.7e-12 44.2 0.4 3.1e-05 23.6 0.0 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDK99455.1 - 6.1e-10 38.8 1.3 5e-05 23.4 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDK99455.1 - 1.2e-09 38.2 21.6 8.8e-05 23.0 1.4 4.9 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDK99455.1 - 1.4e-09 37.3 8.4 0.0025 17.8 0.1 4.6 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDK99455.1 - 4.8e-09 36.7 25.8 7.5e-05 23.3 5.6 3.4 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDK99455.1 - 6.2e-09 35.4 0.7 0.00029 20.5 0.0 2.9 1 1 2 3 3 3 2 TPR repeat TPR_10 PF13374.6 CDK99455.1 - 5.9e-08 32.3 11.5 0.023 14.5 0.5 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDK99455.1 - 2.4e-07 30.9 14.8 2.4e-06 27.8 2.7 3.5 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDK99455.1 - 1.5e-06 27.9 0.0 1.8 9.0 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDK99455.1 - 1.1e-05 25.8 11.6 0.0031 18.0 4.0 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_4 PF07721.14 CDK99455.1 - 5e-05 23.5 24.6 0.0007 20.0 2.0 5.8 4 0 0 4 4 4 2 Tetratricopeptide repeat Glyco_transf_9 PF01075.17 CDK99455.1 - 9.8e-05 21.8 0.1 0.00021 20.7 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) TPR_7 PF13176.6 CDK99455.1 - 0.00096 19.0 10.8 0.0082 16.1 0.0 3.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDK99455.1 - 0.0034 17.5 1.4 0.0034 17.5 1.4 2.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_5 PF12688.7 CDK99455.1 - 0.0041 17.4 1.7 0.011 15.9 1.7 1.7 1 0 0 1 1 1 1 Tetratrico peptide repeat TPR_15 PF13429.6 CDK99455.1 - 0.0093 15.2 7.4 0.072 12.3 4.3 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDK99455.1 - 0.18 12.5 7.9 4 8.3 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat GTA_holin_3TM PF11351.8 CDK99456.1 - 8.2e-18 65.1 1.7 1e-17 64.8 1.7 1.2 1 0 0 1 1 1 1 Holin of 3TMs, for gene-transfer release YscO PF07321.12 CDK99456.1 - 0.0067 16.4 1.4 0.0089 16.0 1.4 1.2 1 0 0 1 1 1 1 Type III secretion protein YscO hnRNP_Q_AcD PF18360.1 CDK99456.1 - 0.086 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain Hydrolase_2 PF07486.12 CDK99457.1 - 9.5e-23 81.0 0.0 1.1e-22 80.8 0.0 1.1 1 0 0 1 1 1 1 Cell Wall Hydrolase DUF4381 PF14316.6 CDK99458.1 - 0.024 14.9 0.3 0.025 14.8 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) CENP-F_leu_zip PF10473.9 CDK99458.1 - 0.078 13.0 0.0 0.096 12.7 0.0 1.0 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PLDc_N PF13396.6 CDK99458.1 - 0.081 12.9 3.6 0.11 12.4 3.6 1.2 1 0 0 1 1 1 0 Phospholipase_D-nuclease N-terminal Apolipoprotein PF01442.18 CDK99458.1 - 0.11 12.3 0.8 0.15 11.9 0.8 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Helicase_RecD PF05127.14 CDK99459.1 - 0.035 14.0 0.0 0.058 13.2 0.0 1.3 1 0 0 1 1 1 0 Helicase DUF429 PF04250.13 CDK99459.1 - 0.06 13.1 2.5 1.9 8.2 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF429) Laminin_G_3 PF13385.6 CDK99461.1 - 3.6e-10 40.2 5.1 3.6e-10 40.2 5.1 3.5 3 0 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Caudal_act PF04731.12 CDK99461.1 - 0.049 14.0 0.2 0.19 12.1 0.2 2.0 1 0 0 1 1 1 0 Caudal like protein activation region DUF3107 PF11305.8 CDK99462.1 - 0.0088 16.3 0.2 0.083 13.1 0.0 2.5 2 1 1 3 3 3 1 Protein of unknown function (DUF3107) PIN_9 PF18477.1 CDK99462.1 - 0.098 13.0 0.3 0.22 11.8 0.2 1.7 1 1 0 1 1 1 0 PIN like domain Collar PF07484.12 CDK99463.1 - 5.7e-24 83.9 0.2 1.5e-23 82.5 0.2 1.8 1 0 0 1 1 1 1 Phage Tail Collar Domain Bactofilin PF04519.13 CDK99463.1 - 0.041 14.2 2.9 1 9.7 1.1 3.1 1 1 2 3 3 3 0 Polymer-forming cytoskeletal MEDS PF14417.6 CDK99463.1 - 0.05 13.4 0.9 0.77 9.6 0.1 2.3 1 1 1 2 2 2 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Tube PF17212.3 CDK99467.1 - 0.00026 21.1 0.0 0.00042 20.4 0.0 1.4 1 1 0 1 1 1 1 Tail tubular protein PGA_cap PF09587.10 CDK99468.1 - 0.017 14.6 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap MCPsignal PF00015.21 CDK99470.1 - 2.1e-11 43.9 7.0 4.9e-08 33.0 1.2 2.3 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF948 PF06103.11 CDK99470.1 - 2.3e-05 24.6 5.1 0.044 14.1 0.3 3.7 1 1 3 4 4 4 1 Bacterial protein of unknown function (DUF948) FliJ PF02050.16 CDK99470.1 - 4.8e-05 23.6 2.0 0.0018 18.5 1.3 2.4 2 0 0 2 2 2 1 Flagellar FliJ protein DASH_Dad2 PF08654.10 CDK99470.1 - 5.2e-05 23.6 5.8 0.041 14.3 1.0 3.9 2 1 2 4 4 3 1 DASH complex subunit Dad2 DUF4795 PF16043.5 CDK99470.1 - 0.00015 21.4 4.2 0.0014 18.3 4.2 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4795) Spc7 PF08317.11 CDK99470.1 - 0.00027 19.9 4.4 0.00037 19.5 3.6 1.5 1 1 0 1 1 1 1 Spc7 kinetochore protein HeLo PF14479.6 CDK99470.1 - 0.0003 20.7 2.5 0.00046 20.1 2.5 1.3 1 0 0 1 1 1 1 Prion-inhibition and propagation Baculo_PEP_C PF04513.12 CDK99470.1 - 0.00032 20.7 6.6 0.0076 16.3 2.2 2.8 2 1 1 3 3 3 1 Baculovirus polyhedron envelope protein, PEP, C terminus CdvA PF18822.1 CDK99470.1 - 0.00038 20.3 5.2 0.008 16.0 0.2 2.4 1 1 1 2 2 2 1 CdvA-like coiled-coil domain Apolipoprotein PF01442.18 CDK99470.1 - 0.00043 20.2 13.7 0.018 14.9 10.6 2.8 1 1 1 2 2 2 1 Apolipoprotein A1/A4/E domain Prominin PF05478.11 CDK99470.1 - 0.00053 18.1 0.6 0.00063 17.9 0.6 1.1 1 0 0 1 1 1 1 Prominin Jnk-SapK_ap_N PF09744.9 CDK99470.1 - 0.0008 19.7 6.1 0.099 12.9 0.1 2.2 1 1 1 2 2 2 2 JNK_SAPK-associated protein-1 Syntaxin_2 PF14523.6 CDK99470.1 - 0.00083 19.7 5.7 0.0056 17.0 2.9 3.2 2 1 1 3 3 2 1 Syntaxin-like protein ALIX_LYPXL_bnd PF13949.6 CDK99470.1 - 0.0022 17.4 4.5 0.0022 17.4 4.5 1.5 2 0 0 2 2 1 1 ALIX V-shaped domain binding to HIV BLOC1_2 PF10046.9 CDK99470.1 - 0.0024 18.1 2.8 2.9 8.2 0.4 3.3 4 0 0 4 4 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 CDK99470.1 - 0.0025 17.8 9.5 0.028 14.4 4.8 3.2 1 1 3 4 4 4 1 Laminin Domain II HisKA_3 PF07730.13 CDK99470.1 - 0.0032 17.9 15.2 3.5 8.2 0.4 4.4 2 1 1 3 3 3 0 Histidine kinase bZIP_1 PF00170.21 CDK99470.1 - 0.0034 17.4 2.0 0.063 13.4 1.0 2.7 2 0 0 2 2 2 1 bZIP transcription factor EzrA PF06160.12 CDK99470.1 - 0.0034 15.6 0.7 0.0054 15.0 0.7 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA HSBP1 PF06825.12 CDK99470.1 - 0.0044 16.9 7.6 0.097 12.5 0.1 3.6 3 0 0 3 3 3 1 Heat shock factor binding protein 1 WXG100 PF06013.12 CDK99470.1 - 0.0046 17.2 4.0 0.45 10.8 1.8 3.3 2 1 0 2 2 2 1 Proteins of 100 residues with WXG Dynamin_M PF01031.20 CDK99470.1 - 0.0046 16.2 0.4 0.0082 15.4 0.4 1.4 1 1 0 1 1 1 1 Dynamin central region Fib_alpha PF08702.10 CDK99470.1 - 0.0078 16.4 4.8 0.99 9.6 1.0 2.3 1 1 1 2 2 2 2 Fibrinogen alpha/beta chain family BLM10_mid PF16507.5 CDK99470.1 - 0.011 14.5 0.1 0.012 14.3 0.1 1.1 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, mid region CENP-F_leu_zip PF10473.9 CDK99470.1 - 0.016 15.2 7.1 0.086 12.9 6.2 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DASH_Dam1 PF08653.10 CDK99470.1 - 0.02 14.7 4.6 1 9.2 0.1 3.6 4 0 0 4 4 3 0 DASH complex subunit Dam1 Tropomyosin_1 PF12718.7 CDK99470.1 - 0.021 15.0 4.6 0.54 10.4 3.1 2.6 1 1 1 2 2 2 0 Tropomyosin like T3SSipB PF16535.5 CDK99470.1 - 0.022 15.3 4.9 15 6.1 0.0 3.1 1 1 2 3 3 3 0 Type III cell invasion protein SipB NPV_P10 PF05531.12 CDK99470.1 - 0.025 15.0 5.1 2 9.0 1.6 3.4 2 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein FapA PF03961.13 CDK99470.1 - 0.036 12.7 0.5 0.042 12.5 0.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A BORCS8 PF10167.9 CDK99470.1 - 0.04 13.8 0.4 0.14 12.1 0.2 2.0 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 8 COG2 PF06148.11 CDK99470.1 - 0.043 13.9 5.2 0.18 11.9 1.8 2.8 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 TolA_bind_tri PF16331.5 CDK99470.1 - 0.043 13.9 1.6 0.043 13.9 1.6 2.9 4 0 0 4 4 3 0 TolA binding protein trimerisation Vps51 PF08700.11 CDK99470.1 - 0.043 13.9 2.0 1.4 9.0 0.2 3.2 3 0 0 3 3 3 0 Vps51/Vps67 Allexi_40kDa PF05549.11 CDK99470.1 - 0.048 13.2 2.6 0.086 12.3 2.0 1.7 1 1 1 2 2 2 0 Allexivirus 40kDa protein Noelin-1 PF12308.8 CDK99470.1 - 0.054 13.5 5.7 1.8 8.6 1.5 2.9 1 1 2 3 3 2 0 Neurogenesis glycoprotein Cytochrom_B562 PF07361.11 CDK99470.1 - 0.055 14.1 3.1 1.4 9.6 0.6 2.9 2 1 0 3 3 2 0 Cytochrome b562 Sec34 PF04136.15 CDK99470.1 - 0.055 13.4 3.4 3.4 7.5 0.7 3.2 2 1 0 3 3 3 0 Sec34-like family Med10 PF09748.9 CDK99470.1 - 0.056 13.4 1.0 1.3 9.0 0.2 2.8 1 1 1 2 2 2 0 Transcription factor subunit Med10 of Mediator complex KASH_CCD PF14662.6 CDK99470.1 - 0.057 13.2 4.1 0.26 11.1 0.0 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH TBK1_CCD1 PF18394.1 CDK99470.1 - 0.066 12.8 2.9 2.5 7.6 0.4 2.8 1 1 2 3 3 3 0 TANK-binding kinase 1 coiled-coil domain 1 AAA_13 PF13166.6 CDK99470.1 - 0.071 11.7 4.0 0.12 11.0 3.8 1.3 1 1 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.12 CDK99470.1 - 0.081 13.0 5.0 0.19 11.8 3.4 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Rx_N PF18052.1 CDK99470.1 - 0.085 13.1 7.6 1 9.7 2.5 2.6 1 1 1 2 2 2 0 Rx N-terminal domain ZapB PF06005.12 CDK99470.1 - 0.088 13.3 4.6 0.11 12.9 3.0 2.1 2 1 0 2 2 1 0 Cell division protein ZapB DUF4407 PF14362.6 CDK99470.1 - 0.09 12.1 6.5 0.19 11.0 5.8 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF1043 PF06295.12 CDK99470.1 - 0.098 12.7 0.8 0.23 11.5 0.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Lectin_N PF03954.14 CDK99470.1 - 0.1 12.3 3.1 1.6 8.5 2.9 2.6 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Filament PF00038.21 CDK99470.1 - 0.11 12.0 7.3 0.38 10.3 7.0 1.8 1 1 0 1 1 1 0 Intermediate filament protein DUF3540 PF12059.8 CDK99470.1 - 0.12 12.2 5.9 1.9 8.3 0.7 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF3540) DUF1664 PF07889.12 CDK99470.1 - 0.12 12.4 5.2 7 6.7 0.4 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) FUSC PF04632.12 CDK99470.1 - 0.12 10.8 9.9 0.29 9.6 9.9 1.7 1 1 0 1 1 1 0 Fusaric acid resistance protein family DASH_Dad3 PF08656.10 CDK99470.1 - 0.14 12.3 6.2 1.1 9.4 1.4 3.1 3 1 0 3 3 2 0 DASH complex subunit Dad3 LPP PF04728.13 CDK99470.1 - 0.19 12.1 6.5 0.47 10.9 0.6 3.5 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Tweety PF04906.13 CDK99470.1 - 0.2 10.3 0.4 0.33 9.6 0.4 1.3 1 0 0 1 1 1 0 Tweety DUF1993 PF09351.10 CDK99470.1 - 0.2 11.8 2.3 1.1 9.3 0.3 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF1993) Occludin_ELL PF07303.13 CDK99470.1 - 0.21 12.3 1.2 7.7 7.3 0.5 2.7 1 1 2 3 3 2 0 Occludin homology domain DUF4061 PF13270.6 CDK99470.1 - 0.21 11.9 5.7 0.71 10.2 2.9 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4061) Seryl_tRNA_N PF02403.22 CDK99470.1 - 0.22 11.8 4.1 0.3 11.3 2.3 2.2 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DASH_Dad1 PF08649.10 CDK99470.1 - 0.22 11.7 2.5 15 5.9 0.3 3.2 2 1 1 3 3 3 0 DASH complex subunit Dad1 Fez1 PF06818.15 CDK99470.1 - 0.22 11.9 5.1 0.35 11.3 5.1 1.3 1 0 0 1 1 1 0 Fez1 Tropomyosin PF00261.20 CDK99470.1 - 0.24 10.8 10.3 0.3 10.4 3.5 2.6 1 1 1 2 2 2 0 Tropomyosin CorA PF01544.18 CDK99470.1 - 0.27 10.5 8.8 4.3 6.6 4.5 2.7 1 1 0 2 2 2 0 CorA-like Mg2+ transporter protein Atg14 PF10186.9 CDK99470.1 - 0.28 10.2 3.1 0.39 9.8 2.7 1.4 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2203 PF09969.9 CDK99470.1 - 0.28 11.9 5.2 0.83 10.4 1.8 2.7 1 1 2 3 3 2 0 Uncharacterized conserved protein (DUF2203) P4Ha_N PF08336.11 CDK99470.1 - 0.3 11.1 2.8 2.9 7.9 0.4 2.9 2 1 0 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF1690 PF07956.11 CDK99470.1 - 0.31 11.5 5.5 0.37 11.2 3.4 2.0 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) LMBR1 PF04791.16 CDK99470.1 - 0.39 9.6 0.3 0.46 9.3 0.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Nmad5 PF18757.1 CDK99470.1 - 0.4 10.8 4.6 13 6.0 0.5 2.6 1 1 0 2 2 2 0 Nucleotide modification associated domain 5 YabA PF06156.13 CDK99470.1 - 0.42 11.3 3.3 9 7.0 1.2 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Macoilin PF09726.9 CDK99470.1 - 0.42 9.1 4.0 0.27 9.8 2.5 1.3 1 1 0 1 1 1 0 Macoilin family phiKZ_IP PF12699.7 CDK99470.1 - 0.49 9.5 6.1 0.67 9.0 1.7 2.3 1 1 1 2 2 2 0 phiKZ-like phage internal head proteins Hemerythrin PF01814.23 CDK99470.1 - 0.51 11.0 7.2 66 4.1 6.0 3.5 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain CK2S PF15011.6 CDK99470.1 - 0.51 10.2 4.1 1.5 8.6 0.9 2.7 1 1 2 3 3 3 0 Casein Kinase 2 substrate Snapin_Pallidin PF14712.6 CDK99470.1 - 0.54 10.7 7.5 0.35 11.3 2.1 3.1 3 1 1 4 4 2 0 Snapin/Pallidin UPF0449 PF15136.6 CDK99470.1 - 0.69 10.4 4.2 9 6.8 0.7 2.9 3 1 0 3 3 2 0 Uncharacterised protein family UPF0449 Reovirus_cap PF00979.17 CDK99470.1 - 0.69 9.0 2.5 1.1 8.3 2.5 1.4 1 0 0 1 1 1 0 Reovirus outer capsid protein, Sigma 3 FlaC_arch PF05377.11 CDK99470.1 - 0.71 10.3 5.4 6.6 7.2 0.6 3.4 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 CDK99470.1 - 0.82 10.1 9.1 0.71 10.3 4.9 2.6 2 1 1 3 3 2 0 Centromere protein H (CENP-H) Mce4_CUP1 PF11887.8 CDK99470.1 - 0.89 9.0 2.9 3.7 6.9 0.2 2.1 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Alanine_zipper PF11839.8 CDK99470.1 - 0.99 9.8 4.9 22 5.5 0.0 3.6 3 0 0 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein XhlA PF10779.9 CDK99470.1 - 1.2 9.4 9.5 24 5.2 0.1 3.8 4 0 0 4 4 3 0 Haemolysin XhlA GIT1_C PF12205.8 CDK99470.1 - 1.3 9.2 4.6 2.2 8.4 0.2 2.6 2 1 0 3 3 2 0 G protein-coupled receptor kinase-interacting protein 1 C term Cep57_MT_bd PF06657.13 CDK99470.1 - 1.4 9.5 5.3 4 8.0 1.7 2.9 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 EMP24_GP25L PF01105.24 CDK99470.1 - 1.8 8.4 5.1 4.9 7.0 0.4 2.7 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD PspB PF06667.12 CDK99470.1 - 7.6 6.7 6.0 36 4.5 0.9 3.0 3 0 0 3 3 2 0 Phage shock protein B DUF2934 PF11154.8 CDK99471.1 - 9.5e-15 54.0 4.6 1.2e-14 53.7 4.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2934) vMSA PF00695.19 CDK99471.1 - 0.029 13.5 0.6 0.031 13.4 0.6 1.0 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus CBS PF00571.28 CDK99472.1 - 1.3e-23 83.2 1.0 2.4e-12 47.1 0.1 2.2 2 0 0 2 2 2 2 CBS domain GGDEF PF00990.21 CDK99473.1 - 8.4e-49 165.4 0.3 1.5e-48 164.6 0.3 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain dCache_1 PF02743.18 CDK99473.1 - 1.9e-08 34.4 0.0 3.4e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Cache domain GGDEF_2 PF17853.1 CDK99473.1 - 0.028 14.7 0.2 0.084 13.1 0.2 1.8 1 0 0 1 1 1 0 GGDEF-like domain AMIN PF11741.8 CDK99474.1 - 0.068 13.3 0.0 1.5 9.0 0.0 2.3 2 1 1 3 3 3 0 AMIN domain Asp1 PF16993.5 CDK99474.1 - 0.3 10.3 0.0 0.36 10.0 0.0 1.1 1 0 0 1 1 1 0 Accessory Sec system protein Asp1 DUF485 PF04341.12 CDK99475.1 - 6e-27 93.4 2.6 6.7e-27 93.3 2.6 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF485 TrbC PF04956.13 CDK99475.1 - 0.013 15.6 0.6 0.016 15.4 0.6 1.1 1 0 0 1 1 1 0 TrbC/VIRB2 family DUF2663 PF10864.8 CDK99475.1 - 0.038 14.4 0.0 0.044 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) DUF4407 PF14362.6 CDK99475.1 - 2.1 7.6 5.3 2.5 7.4 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SSF PF00474.17 CDK99476.1 - 6.1e-112 374.5 39.5 6.1e-112 374.5 39.5 1.8 2 0 0 2 2 2 1 Sodium:solute symporter family Fructosamin_kin PF03881.14 CDK99477.1 - 9.9e-48 162.8 0.0 1.1e-47 162.7 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 CDK99477.1 - 2.8e-14 53.7 2.2 3.7e-14 53.2 2.2 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDK99477.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase LMWPc PF01451.21 CDK99478.1 - 1.8e-45 154.8 0.0 2e-45 154.6 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase SIR2 PF02146.17 CDK99479.1 - 8.8e-47 159.3 0.0 1e-46 159.1 0.0 1.1 1 0 0 1 1 1 1 Sir2 family TraU PF06834.11 CDK99479.1 - 0.025 13.8 0.0 0.032 13.5 0.0 1.1 1 0 0 1 1 1 0 TraU protein Tmemb_55A PF09788.9 CDK99479.1 - 0.03 13.4 0.1 0.038 13.1 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 55A zf-LITAF-like PF10601.9 CDK99479.1 - 0.036 14.3 0.3 0.07 13.4 0.3 1.4 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain zinc_ribbon_5 PF13719.6 CDK99479.1 - 0.59 9.9 2.9 2.7 7.8 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain K_trans PF02705.16 CDK99480.1 - 2.2e-204 679.9 25.7 2.6e-204 679.7 25.7 1.0 1 0 0 1 1 1 1 K+ potassium transporter ATP-synt_B PF00430.18 CDK99482.1 - 1.5e-24 86.6 23.2 2.4e-24 85.9 23.2 1.3 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) Mt_ATP-synt_B PF05405.14 CDK99482.1 - 1.6e-11 44.1 0.9 1.9e-11 43.9 0.9 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) dCache_1 PF02743.18 CDK99482.1 - 0.2 11.4 2.0 0.31 10.8 2.0 1.4 1 0 0 1 1 1 0 Cache domain TMPIT PF07851.13 CDK99482.1 - 0.73 9.0 2.8 0.91 8.7 2.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein CREPT PF16566.5 CDK99482.1 - 0.75 10.0 11.1 0.18 11.9 5.5 2.1 1 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour MutS_IV PF05190.18 CDK99482.1 - 2.4 8.6 4.8 3.2 8.2 0.8 2.2 1 1 1 2 2 2 0 MutS family domain IV OmpH PF03938.14 CDK99482.1 - 3.5 8.0 20.7 5 7.5 20.7 1.3 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Folliculin PF11704.8 CDK99482.1 - 4.1 7.3 5.7 5.1 6.9 5.7 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Cytadhesin_P30 PF07271.11 CDK99482.1 - 7.1 6.1 6.7 2.4 7.7 1.2 1.9 1 1 1 2 2 2 0 Cytadhesin P30/P32 ATP-synt_B PF00430.18 CDK99483.1 - 1.5e-26 93.0 14.3 2.4e-26 92.4 14.3 1.3 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) YMF19 PF02326.15 CDK99483.1 - 2e-12 47.7 0.0 3.6e-12 46.9 0.0 1.6 1 1 0 1 1 1 1 Plant ATP synthase F0 Mt_ATP-synt_B PF05405.14 CDK99483.1 - 2.3e-08 33.8 0.9 2.6e-08 33.7 0.9 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) NACHT_N PF17100.5 CDK99483.1 - 0.0027 17.6 4.9 0.0033 17.3 4.9 1.1 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase Fun_ATP-synt_8 PF05933.13 CDK99483.1 - 0.0042 17.2 0.4 0.0059 16.7 0.4 1.2 1 0 0 1 1 1 1 Fungal ATP synthase protein 8 (A6L) DUF3037 PF11236.8 CDK99483.1 - 0.051 14.0 1.5 0.075 13.5 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3037) DUF948 PF06103.11 CDK99483.1 - 0.1 12.8 3.0 0.24 11.7 0.6 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Remorin_C PF03763.13 CDK99483.1 - 0.2 11.5 9.9 0.36 10.7 9.9 1.5 1 0 0 1 1 1 0 Remorin, C-terminal region ATP-synt_C PF00137.21 CDK99484.1 - 7.3e-13 48.6 11.0 9.1e-13 48.4 11.0 1.1 1 0 0 1 1 1 1 ATP synthase subunit C ATP-synt_A PF00119.20 CDK99485.1 - 9.1e-57 192.4 28.2 1.1e-56 192.2 28.2 1.0 1 0 0 1 1 1 1 ATP synthase A chain ATPase_gene1 PF09527.10 CDK99486.1 - 3e-16 59.3 8.2 4.3e-16 58.8 8.2 1.2 1 0 0 1 1 1 1 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter SMC_N PF02463.19 CDK99487.1 - 2.3e-57 193.9 0.0 3.2e-57 193.5 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDK99487.1 - 1.2e-13 52.0 0.0 1.2e-13 52.0 0.0 4.0 3 2 0 3 3 3 1 AAA domain AAA_21 PF13304.6 CDK99487.1 - 2.4e-10 40.7 0.0 5.4e-06 26.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDK99487.1 - 2.2e-05 24.4 0.0 3.8e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 CDK99487.1 - 2.6e-05 24.7 1.6 0.021 15.3 0.0 3.7 3 0 0 3 3 3 2 ABC transporter DUF1664 PF07889.12 CDK99487.1 - 0.011 15.8 0.1 0.011 15.8 0.1 6.8 4 1 3 8 8 8 0 Protein of unknown function (DUF1664) AAA_29 PF13555.6 CDK99487.1 - 0.012 15.3 0.0 0.029 14.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain LTXXQ PF07813.12 CDK99487.1 - 0.014 16.1 1.5 0.014 16.1 1.5 8.5 3 2 5 9 9 9 0 LTXXQ motif family protein SMC_hinge PF06470.13 CDK99487.1 - 5.4 7.3 9.3 18 5.7 0.1 4.0 4 1 1 5 5 5 0 SMC proteins Flexible Hinge Domain Thioredoxin_4 PF13462.6 CDK99488.1 - 1.5e-37 129.3 0.0 1.7e-37 129.1 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 CDK99488.1 - 1.2e-07 31.7 0.0 0.0015 18.4 0.0 2.1 2 0 0 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 CDK99488.1 - 0.0029 18.0 0.0 0.77 10.2 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_3 PF13192.6 CDK99488.1 - 0.0099 15.9 0.0 0.14 12.2 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin domain DciA PF05258.12 CDK99489.1 - 5.2e-18 65.2 0.0 7.6e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Dna[CI] antecedent, DciA DEC-1_N PF04625.13 CDK99489.1 - 0.075 12.0 0.7 0.089 11.8 0.7 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region NUDIX_4 PF14815.6 CDK99490.1 - 3.2e-22 78.6 0.3 6.7e-22 77.6 0.3 1.5 1 0 0 1 1 1 1 NUDIX domain HhH-GPD PF00730.25 CDK99490.1 - 6.2e-18 65.2 0.0 9.4e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CDK99490.1 - 2.5e-06 27.1 0.0 5.2e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 CDK99490.1 - 0.00041 20.6 5.1 0.001 19.3 5.1 1.7 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III DUF4436 PF14494.6 CDK99491.1 - 0.0039 16.5 0.2 0.59 9.4 0.0 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4436) GTP_EFTU PF00009.27 CDK99492.1 - 1e-47 162.2 0.0 1.6e-47 161.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RF3_C PF16658.5 CDK99492.1 - 8.2e-44 148.6 0.0 1.4e-43 147.9 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 CDK99492.1 - 4.4e-07 30.2 0.0 1.1e-06 29.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDK99492.1 - 3.7e-05 23.8 0.0 7e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDK99492.1 - 0.007 15.9 0.0 0.16 11.5 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B EFG_II PF14492.6 CDK99492.1 - 0.016 15.3 0.0 0.03 14.4 0.0 1.5 1 0 0 1 1 1 0 Elongation Factor G, domain II SRPRB PF09439.10 CDK99492.1 - 0.092 12.2 0.0 0.31 10.5 0.0 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit RHH_1 PF01402.21 CDK99493.1 - 0.082 12.9 0.3 0.14 12.2 0.3 1.4 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family Cadherin_4 PF17803.1 CDK99494.1 - 4.7e-05 23.9 5.8 4.7e-05 23.9 5.8 35.0 20 10 10 31 31 31 8 Bacterial cadherin-like domain Big_9 PF17963.1 CDK99494.1 - 5.4e-05 23.8 9.1 5.4e-05 23.8 9.1 33.6 16 8 8 27 27 27 7 Bacterial Ig domain Secretin_N PF03958.17 CDK99494.1 - 7.1 7.1 13.6 0.76 10.2 0.1 5.5 5 0 0 5 5 5 0 Bacterial type II/III secretion system short domain HlyD_3 PF13437.6 CDK99495.1 - 2.2e-15 57.3 0.3 2.1e-13 50.9 0.0 2.6 2 0 0 2 2 2 1 HlyD family secretion protein HlyD PF00529.20 CDK99495.1 - 5.2e-07 29.5 0.0 1.4e-06 28.1 0.0 1.8 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl_2 PF13533.6 CDK99495.1 - 9.7e-06 25.3 0.5 9.7e-06 25.3 0.5 2.6 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_D23 PF16576.5 CDK99495.1 - 5e-05 22.6 8.6 0.014 14.6 8.6 2.6 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl PF00364.22 CDK99495.1 - 0.0003 20.5 1.1 0.3 11.0 0.2 2.5 2 0 0 2 2 2 2 Biotin-requiring enzyme Nas2_N PF18265.1 CDK99495.1 - 0.073 13.0 0.5 0.17 11.8 0.5 1.7 1 0 0 1 1 1 0 Nas2 N_terminal domain FlaC_arch PF05377.11 CDK99495.1 - 0.093 13.1 8.7 0.28 11.6 0.0 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF724 PF05266.14 CDK99495.1 - 0.24 11.2 4.8 0.35 10.7 4.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Exonuc_VII_L PF02601.15 CDK99495.1 - 0.45 10.0 5.6 0.78 9.3 5.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit TBCC_N PF16752.5 CDK99495.1 - 0.8 10.2 6.4 11 6.5 7.1 2.5 2 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain zf-CpG_bind_C PF12269.8 CDK99495.1 - 1.3 8.7 7.7 2.9 7.6 3.3 2.4 1 1 0 2 2 2 0 CpG binding protein zinc finger C terminal domain FlxA PF14282.6 CDK99495.1 - 2.9 7.9 10.3 30 4.7 0.0 2.4 1 1 1 2 2 2 0 FlxA-like protein OEP PF02321.18 CDK99495.1 - 8.7 6.1 18.6 0.84 9.4 12.6 2.1 2 0 0 2 2 2 0 Outer membrane efflux protein ABC_tran PF00005.27 CDK99496.1 - 1e-23 84.4 0.0 2.5e-23 83.1 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDK99496.1 - 8.5e-13 48.6 4.5 1.2e-12 48.0 4.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.6 CDK99496.1 - 1.1e-10 41.8 0.0 4.8e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDK99496.1 - 7.6e-09 35.3 1.1 0.00012 21.6 0.0 2.5 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDK99496.1 - 0.00067 20.1 0.2 0.0019 18.6 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 CDK99496.1 - 0.0019 18.0 0.0 0.0034 17.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDK99496.1 - 0.0027 17.4 0.0 0.0061 16.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 CDK99496.1 - 0.0075 16.4 0.0 0.038 14.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 CDK99496.1 - 0.0091 16.1 0.0 2.3 8.3 0.0 2.3 2 0 0 2 2 2 1 Dynamin family Zeta_toxin PF06414.12 CDK99496.1 - 0.042 13.1 0.0 0.092 12.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 CDK99496.1 - 0.066 13.5 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDK99496.1 - 0.076 13.5 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDK99496.1 - 0.087 12.5 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDK99496.1 - 0.098 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase ABC_membrane PF00664.23 CDK99497.1 - 1.2e-23 84.1 2.4 1.5e-23 83.8 2.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDK99497.1 - 3.7e-23 82.6 0.0 6.9e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDK99497.1 - 1.3e-05 24.8 0.0 0.0039 16.7 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDK99497.1 - 0.00011 22.6 0.0 0.00024 21.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CDK99497.1 - 0.0016 18.4 0.0 0.16 11.9 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_29 PF13555.6 CDK99497.1 - 0.0087 15.8 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDK99497.1 - 0.019 15.5 0.0 0.034 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDK99497.1 - 0.036 13.6 0.0 0.16 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain HK_sensor PF16750.5 CDK99497.1 - 0.062 13.6 0.0 5.8 7.3 0.1 2.4 2 0 0 2 2 2 0 Sensor domain of 2-component histidine kinase Zeta_toxin PF06414.12 CDK99497.1 - 0.068 12.4 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_21 PF13304.6 CDK99497.1 - 0.15 11.8 0.1 0.3 10.8 0.0 1.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CDK99497.1 - 0.16 12.2 0.1 1.8 8.8 0.1 2.3 1 1 0 1 1 1 0 AAA domain Myc_target_1 PF15179.6 CDK99498.1 - 0.28 11.1 0.3 0.27 11.1 0.3 1.0 1 0 0 1 1 1 0 Myc target protein 1 MCPsignal PF00015.21 CDK99499.1 - 5.2e-20 72.0 18.0 1.4e-19 70.5 14.1 2.7 2 1 1 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain LXG PF04740.12 CDK99499.1 - 0.0011 18.7 2.0 0.0025 17.6 2.0 1.6 1 0 0 1 1 1 1 LXG domain of WXG superfamily P-mevalo_kinase PF04275.14 CDK99499.1 - 0.034 14.1 0.9 0.073 13.0 0.9 1.5 1 0 0 1 1 1 0 Phosphomevalonate kinase DUF2009 PF09418.10 CDK99499.1 - 0.038 13.1 0.2 0.058 12.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) DDE_Tnp_1_6 PF13751.6 CDK99499.1 - 0.21 11.8 0.7 0.43 10.8 0.7 1.5 1 0 0 1 1 1 0 Transposase DDE domain YkyA PF10368.9 CDK99499.1 - 0.31 10.7 4.8 0.52 10.0 4.8 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein DUF1664 PF07889.12 CDK99499.1 - 0.31 11.1 9.5 17 5.5 4.2 3.4 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 CDK99499.1 - 2.5 8.1 6.8 7.2 6.7 0.2 3.4 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cauli_DNA-bind PF03310.13 CDK99499.1 - 3.6 7.7 5.1 24 5.0 0.0 2.9 2 1 1 3 3 3 0 Caulimovirus DNA-binding protein DUF2203 PF09969.9 CDK99499.1 - 5 7.9 6.6 23 5.7 1.5 2.8 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) HTH_Tnp_IS630 PF01710.16 CDK99500.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK99500.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK99500.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK99500.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK99500.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK99500.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDK99501.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK99501.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain DUF4143 PF13635.6 CDK99502.1 - 8.2e-25 87.3 0.0 1.1e-24 86.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4143) AAA_14 PF13173.6 CDK99502.1 - 3.1e-24 85.5 0.0 4.3e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CDK99502.1 - 0.0067 16.0 0.1 0.047 13.3 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 CDK99502.1 - 0.027 14.9 0.6 0.97 9.8 0.0 2.7 2 1 1 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 CDK99502.1 - 0.035 14.4 0.1 10 6.4 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 CDK99502.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CDK99502.1 - 0.11 12.3 0.0 0.84 9.5 0.0 2.0 1 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 CDK99502.1 - 0.12 12.4 0.1 1 9.4 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2384 PF09722.10 CDK99503.1 - 4.9e-08 32.9 0.0 8.3e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2384) HTH_3 PF01381.22 CDK99504.1 - 1.8e-09 37.5 0.0 3.4e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 CDK99504.1 - 7.2e-09 35.5 0.0 3e-08 33.6 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_31 PF13560.6 CDK99504.1 - 8.4e-09 35.6 0.4 1.5e-08 34.9 0.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Peptidase_S24 PF00717.23 CDK99504.1 - 1.2e-06 28.3 0.0 2.1e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase S24-like HTH_26 PF13443.6 CDK99504.1 - 8.5e-05 22.9 0.0 0.00014 22.2 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_37 PF13744.6 CDK99504.1 - 0.051 13.5 0.0 0.077 13.0 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 CDK99504.1 - 0.076 12.8 0.0 0.25 11.2 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain RIFIN PF02009.16 CDK99507.1 - 0.47 10.3 3.4 0.51 10.2 3.4 1.1 1 0 0 1 1 1 0 Rifin DUF3684 PF12449.8 CDK99507.1 - 0.88 7.3 4.6 1.1 6.9 4.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3684) DUF1833 PF08875.11 CDK99511.1 - 1.3e-73 245.5 0.1 1.5e-73 245.3 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1833) DUF736 PF05284.12 CDK99511.1 - 0.019 14.8 0.0 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF736) PIN PF01850.21 CDK99512.1 - 3.5e-15 56.6 0.1 4e-15 56.4 0.1 1.0 1 0 0 1 1 1 1 PIN domain DUF5615 PF18480.1 CDK99512.1 - 0.019 14.7 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) DUF4411 PF14367.6 CDK99512.1 - 0.074 13.0 0.0 0.087 12.7 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4411) PhdYeFM_antitox PF02604.19 CDK99513.1 - 2.2e-16 59.4 0.0 2.4e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Antitoxin Phd_YefM, type II toxin-antitoxin system Dus PF01207.17 CDK99513.1 - 0.17 10.9 0.0 0.19 10.8 0.0 1.1 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) NLPC_P60 PF00877.19 CDK99514.1 - 8.7e-06 25.7 0.0 1.1e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 NlpC/P60 family Phage-tail_3 PF13550.6 CDK99515.1 - 5.9e-26 91.3 0.0 1.3e-25 90.1 0.0 1.6 1 0 0 1 1 1 1 Putative phage tail protein Lambda_tail_I PF06805.12 CDK99515.1 - 7e-25 87.2 0.7 2.2e-24 85.6 0.7 1.9 1 0 0 1 1 1 1 Bacteriophage lambda tail assembly protein I DUF3040 PF11239.8 CDK99517.1 - 0.016 15.5 2.9 1.1 9.6 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) RepB PF07506.11 CDK99518.1 - 7.2e-08 32.7 0.0 1.2e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 RepB plasmid partitioning protein MYO10_CC PF16735.5 CDK99518.1 - 0.003 17.6 0.2 0.27 11.4 0.0 2.2 2 0 0 2 2 2 2 Unconventional myosin-X coiled coil domain Miff PF05644.11 CDK99518.1 - 0.024 14.3 0.0 0.03 14.0 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Response_reg PF00072.24 CDK99519.1 - 1e-19 70.7 0.0 1.3e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain HEAT_2 PF13646.6 CDK99520.1 - 2.7e-10 40.5 11.4 3.4e-08 33.7 1.8 3.6 2 1 1 3 3 3 2 HEAT repeats HEAT_PBS PF03130.16 CDK99520.1 - 0.00026 21.3 0.6 0.00026 21.3 0.6 4.5 5 0 0 5 5 5 1 PBS lyase HEAT-like repeat TFIID_20kDa PF03847.13 CDK99520.1 - 0.0084 16.6 0.4 0.1 13.1 0.0 2.4 1 1 1 2 2 2 1 Transcription initiation factor TFIID subunit A MgtE_N PF03448.17 CDK99520.1 - 0.18 12.4 1.5 1.4 9.5 0.4 2.9 3 0 0 3 3 3 0 MgtE intracellular N domain HEAT_EZ PF13513.6 CDK99520.1 - 0.42 11.2 4.0 30 5.3 0.5 3.9 2 1 1 3 3 3 0 HEAT-like repeat CitG PF01874.16 CDK99521.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 ATP:dephospho-CoA triphosphoribosyl transferase Pkinase PF00069.25 CDK99522.1 - 8.2e-08 31.9 0.0 3.1e-07 30.0 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain SHOCT PF09851.9 CDK99522.1 - 1.3e-05 24.8 0.3 2.7e-05 23.8 0.3 1.6 1 0 0 1 1 1 1 Short C-terminal domain APH PF01636.23 CDK99522.1 - 9.1e-05 22.5 0.7 0.018 14.9 0.3 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family GvpG PF05120.12 CDK99522.1 - 0.15 12.1 0.1 0.48 10.5 0.0 1.8 2 0 0 2 2 2 0 Gas vesicle protein G VWA_2 PF13519.6 CDK99523.1 - 0.012 16.2 0.0 0.078 13.6 0.0 2.2 1 1 0 1 1 1 0 von Willebrand factor type A domain VapB_antitoxin PF09957.9 CDK99523.1 - 0.024 14.5 0.8 0.15 12.0 0.1 2.4 2 1 0 2 2 2 0 Bacterial antitoxin of type II TA system, VapB FeoB_N PF02421.18 CDK99527.1 - 2.6e-53 179.8 0.0 3.9e-53 179.2 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Gate PF07670.14 CDK99527.1 - 3.3e-43 146.5 14.6 1.1e-29 103.0 0.4 2.9 2 0 0 2 2 2 2 Nucleoside recognition FeoB_C PF07664.12 CDK99527.1 - 3.1e-18 65.2 0.6 3.1e-18 65.2 0.6 2.6 2 0 0 2 2 2 1 Ferrous iron transport protein B C terminus FeoB_Cyto PF17910.1 CDK99527.1 - 8.7e-17 61.5 0.9 1.9e-16 60.4 0.3 2.0 2 0 0 2 2 2 1 FeoB cytosolic helical domain MMR_HSR1 PF01926.23 CDK99527.1 - 1.3e-16 60.7 0.0 3.1e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CDK99527.1 - 3.3e-05 23.3 0.2 7e-05 22.3 0.1 1.6 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 CDK99527.1 - 0.0035 17.4 0.1 0.93 9.5 0.0 2.5 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.10 CDK99527.1 - 0.0043 16.5 0.0 0.0077 15.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit TALPID3 PF15324.6 CDK99527.1 - 0.24 9.0 0.2 0.33 8.6 0.2 1.1 1 0 0 1 1 1 0 Hedgehog signalling target FeoA PF04023.14 CDK99528.1 - 2e-13 50.4 0.1 2.3e-13 50.2 0.1 1.1 1 0 0 1 1 1 1 FeoA domain CZB PF13682.6 CDK99529.1 - 2.8e-21 75.7 3.9 1e-09 38.7 0.7 2.2 2 0 0 2 2 2 2 Chemoreceptor zinc-binding domain HTH_Tnp_1 PF01527.20 CDK99530.1 - 3e-16 59.5 0.3 4.5e-16 58.9 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDK99530.1 - 3.9e-06 26.5 0.0 6.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 CDK99530.1 - 0.0076 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 CDK99530.1 - 0.02 15.0 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 CDK99530.1 - 0.045 13.4 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.6 CDK99530.1 - 0.076 13.0 0.2 0.68 10.0 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn helix HTH_35 PF13693.6 CDK99530.1 - 0.13 12.3 0.0 1 9.4 0.0 2.0 1 1 1 2 2 2 0 Winged helix-turn-helix DNA-binding TnpB_IS66 PF05717.13 CDK99531.1 - 9.3e-38 128.2 0.0 1e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein DDE_Tnp_IS66 PF03050.14 CDK99532.1 - 2.9e-89 299.3 0.4 4.9e-89 298.6 0.0 1.6 2 0 0 2 2 2 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK99532.1 - 2.9e-18 65.8 0.0 1e-17 64.0 0.0 2.0 1 0 0 1 1 1 1 IS66 C-terminal element LZ_Tnp_IS66 PF13007.7 CDK99532.1 - 3e-16 59.9 4.3 3e-16 59.9 4.3 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDK99532.1 - 1.5e-15 57.3 4.6 2.9e-15 56.4 4.6 1.5 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDK99532.1 - 0.18 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.12 CDK99532.1 - 1.1 10.0 3.9 11 6.8 2.2 2.9 2 1 1 3 3 3 0 SlyX Pkinase PF00069.25 CDK99533.1 - 1.2e-09 38.0 0.0 2.6e-09 36.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 CDK99533.1 - 0.00017 21.6 1.5 0.001 19.0 0.4 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDK99533.1 - 0.027 14.1 0.0 0.058 13.0 0.0 1.5 2 0 0 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.22 CDK99533.1 - 0.03 13.9 0.0 0.31 10.6 0.0 2.0 2 0 0 2 2 2 0 RIO1 family Kinase-like PF14531.6 CDK99533.1 - 0.035 13.4 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 CDK99533.1 - 0.041 13.2 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PP2C_2 PF13672.6 CDK99534.1 - 0.0026 17.4 0.0 0.0077 15.9 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CDK99534.1 - 0.012 15.5 0.0 0.046 13.6 0.0 1.9 1 1 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) vWA-TerF-like PF10138.9 CDK99535.1 - 0.024 14.7 0.0 3.9 7.5 0.0 2.2 2 0 0 2 2 2 0 vWA found in TerF C terminus VWA_2 PF13519.6 CDK99535.1 - 0.072 13.7 0.0 3.3 8.4 0.0 2.4 2 0 0 2 2 2 0 von Willebrand factor type A domain Talin_middle PF09141.10 CDK99536.1 - 0.0048 16.9 8.3 0.082 12.9 2.0 2.5 1 1 1 2 2 2 2 Talin, middle domain DUF1512 PF07431.12 CDK99536.1 - 0.0075 15.3 0.3 0.61 9.0 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1512) Nipped-B_C PF12830.7 CDK99536.1 - 0.011 15.6 1.1 0.12 12.3 1.1 2.2 1 1 0 1 1 1 0 Sister chromatid cohesion C-terminus DUF4276 PF14103.6 CDK99536.1 - 0.026 14.8 0.3 12 6.1 0.1 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4276) SelB-wing_1 PF09105.10 CDK99536.1 - 0.038 14.0 1.7 6.9 6.7 0.3 2.8 2 0 0 2 2 2 0 Elongation factor SelB, winged helix CARD PF00619.21 CDK99536.1 - 0.07 13.2 0.1 0.23 11.5 0.1 2.0 1 0 0 1 1 1 0 Caspase recruitment domain DUF948 PF06103.11 CDK99536.1 - 0.18 12.1 12.8 0.17 12.2 2.7 3.8 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF3416 PF11896.8 CDK99536.1 - 0.71 10.2 4.4 1.9 8.8 4.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3416) MCR PF18509.1 CDK99537.1 - 5e-27 93.1 9.0 6.6e-14 51.2 2.1 2.5 2 0 0 2 2 2 2 Magnetochrome domain Nudix_N_2 PF14803.6 CDK99537.1 - 0.0014 18.5 2.0 0.49 10.4 0.1 2.3 2 0 0 2 2 2 2 Nudix N-terminal CCP_MauG PF03150.14 CDK99537.1 - 0.0088 16.7 0.6 0.55 10.9 0.0 2.2 1 1 1 2 2 2 1 Di-haem cytochrome c peroxidase DUF1924 PF09086.11 CDK99537.1 - 0.012 16.0 2.0 0.83 10.1 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1924) Cytochrome_C7 PF14522.6 CDK99537.1 - 0.041 13.9 0.9 0.12 12.4 0.9 1.7 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CDK99537.1 - 0.081 12.7 1.8 0.46 10.3 1.9 2.0 1 1 1 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_CBB3 PF13442.6 CDK99537.1 - 0.086 13.2 3.5 2.2 8.7 0.2 2.5 1 1 1 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_c3_2 PF14537.6 CDK99537.1 - 0.28 11.7 1.9 1.4 9.4 1.9 1.9 1 1 0 1 1 1 0 Cytochrome c3 Cytochrom_C PF00034.21 CDK99537.1 - 0.78 10.9 4.6 4 8.6 0.4 2.3 1 1 1 2 2 2 0 Cytochrome c MFS_1 PF07690.16 CDK99538.1 - 4.2e-21 75.3 58.5 1.6e-10 40.5 36.4 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Ferric_reduct PF01794.19 CDK99538.1 - 2.8e-16 59.8 3.6 2.8e-16 59.8 3.6 3.3 3 1 0 3 3 3 1 Ferric reductase like transmembrane component OATP PF03137.20 CDK99538.1 - 0.096 11.0 6.8 1 7.6 0.2 2.6 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Tubulin PF00091.25 CDK99539.1 - 4.9e-40 137.8 0.5 7.3e-40 137.3 0.5 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.8 CDK99539.1 - 8.3e-37 125.4 2.1 8.3e-37 125.4 2.1 2.2 2 0 0 2 2 2 1 FtsZ family, C-terminal domain Tubulin_2 PF13809.6 CDK99539.1 - 0.0019 17.4 8.0 0.0082 15.4 1.8 2.6 1 1 1 2 2 2 2 Tubulin like DDE_3 PF13358.6 CDK99541.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK99541.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDK99542.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK99542.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK99542.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK99542.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK99542.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK99542.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain HTH_Tnp_1 PF01527.20 CDK99543.1 - 3e-16 59.5 0.3 4.5e-16 58.9 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDK99543.1 - 3.9e-06 26.5 0.0 6.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 CDK99543.1 - 0.0076 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 CDK99543.1 - 0.02 15.0 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 CDK99543.1 - 0.045 13.4 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.6 CDK99543.1 - 0.076 13.0 0.2 0.68 10.0 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn helix HTH_35 PF13693.6 CDK99543.1 - 0.13 12.3 0.0 1 9.4 0.0 2.0 1 1 1 2 2 2 0 Winged helix-turn-helix DNA-binding TnpB_IS66 PF05717.13 CDK99544.1 - 9.3e-38 128.2 0.0 1e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein DDE_Tnp_IS66 PF03050.14 CDK99545.1 - 2.9e-89 299.3 0.4 4.9e-89 298.6 0.0 1.6 2 0 0 2 2 2 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK99545.1 - 2.9e-18 65.8 0.0 1e-17 64.0 0.0 2.0 1 0 0 1 1 1 1 IS66 C-terminal element LZ_Tnp_IS66 PF13007.7 CDK99545.1 - 3e-16 59.9 4.3 3e-16 59.9 4.3 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDK99545.1 - 1.5e-15 57.3 4.6 2.9e-15 56.4 4.6 1.5 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDK99545.1 - 0.18 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.12 CDK99545.1 - 1.1 10.0 3.9 11 6.8 2.2 2.9 2 1 1 3 3 3 0 SlyX DDE_Tnp_1 PF01609.21 CDK99546.1 - 1.9e-08 34.2 0.2 5.9e-07 29.4 0.2 2.1 1 1 0 1 1 1 1 Transposase DDE domain DUF772 PF05598.11 CDK99547.1 - 3e-11 43.2 0.0 4e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Transposase domain (DUF772) DUF772 PF05598.11 CDK99548.1 - 0.077 13.0 0.0 0.48 10.5 0.0 1.9 2 0 0 2 2 2 0 Transposase domain (DUF772) rve PF00665.26 CDK99550.1 - 1.3e-14 54.4 0.0 2.4e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain IstB_IS21 PF01695.17 CDK99551.1 - 3.6e-15 56.1 0.0 5.2e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein PhoH PF02562.16 CDK99551.1 - 0.017 14.6 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein DDE_Tnp_IS66 PF03050.14 CDK99552.1 - 2.4e-88 296.3 0.0 3e-88 296.0 0.0 1.1 1 0 0 1 1 1 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK99552.1 - 3.1e-11 43.3 0.0 7.2e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 IS66 C-terminal element NTase_sub_bind PF08780.11 CDK99552.1 - 0.19 11.7 0.1 0.32 11.0 0.1 1.3 1 0 0 1 1 1 0 Nucleotidyltransferase substrate binding protein like LZ_Tnp_IS66 PF13007.7 CDK99553.1 - 1.3e-16 61.2 4.5 1.3e-16 61.2 4.5 2.0 1 1 1 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDK99553.1 - 0.00016 22.0 0.9 0.00029 21.2 0.9 1.4 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDK99553.1 - 0.04 13.8 0.1 0.048 13.5 0.1 1.1 1 0 0 1 1 1 0 Spindle Pole Component 29 DUF2259 PF10016.9 CDK99553.1 - 0.042 13.8 2.2 0.056 13.4 1.5 1.4 1 1 1 2 2 2 0 Predicted secreted protein (DUF2259) SlyX PF04102.12 CDK99553.1 - 0.12 13.0 2.6 0.21 12.2 1.6 1.9 1 1 0 1 1 1 0 SlyX TnpB_IS66 PF05717.13 CDK99554.1 - 3.7e-17 62.1 0.0 4.1e-17 62.0 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein TruB_C PF09142.11 CDK99554.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal TnpB_IS66 PF05717.13 CDK99555.1 - 1.5e-13 50.5 0.0 1.6e-13 50.4 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein HTH_Tnp_1 PF01527.20 CDK99556.1 - 1.2e-16 60.7 0.1 1.7e-16 60.3 0.1 1.2 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDK99556.1 - 0.03 14.1 0.2 0.048 13.5 0.2 1.3 1 0 0 1 1 1 0 Homeodomain-like domain MerR_1 PF13411.6 CDK99556.1 - 0.17 12.0 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 MerR HTH family regulatory protein Response_reg PF00072.24 CDK99557.1 - 0.1 12.8 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Response regulator receiver domain DUF2798 PF11391.8 CDK99558.1 - 8.2e-22 77.0 5.6 9.6e-22 76.8 5.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2798) DUF1475 PF07343.11 CDK99558.1 - 0.0097 15.7 1.5 0.011 15.6 1.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1475) PufQ PF05398.11 CDK99558.1 - 0.23 11.6 0.2 0.23 11.6 0.2 2.0 1 1 0 2 2 2 0 PufQ cytochrome subunit Cation_efflux PF01545.21 CDK99559.1 - 5.8e-27 94.7 14.2 8.3e-27 94.2 14.2 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CDK99559.1 - 1.9e-10 40.7 0.0 3.4e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF4536 PF15055.6 CDK99559.1 - 0.15 12.3 0.1 0.15 12.3 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4536) Rhomboid PF01694.22 CDK99559.1 - 2.3 8.2 7.9 3.6 7.6 7.2 1.7 1 1 0 1 1 1 0 Rhomboid family CZB PF13682.6 CDK99560.1 - 2.9e-11 43.6 1.6 3.8e-11 43.2 1.6 1.2 1 0 0 1 1 1 1 Chemoreceptor zinc-binding domain HTH_17 PF12728.7 CDK99561.1 - 0.0006 19.9 0.0 0.00088 19.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain UPF0175 PF03683.13 CDK99561.1 - 0.052 13.3 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0175) Cation_efflux PF01545.21 CDK99562.1 - 2.3e-32 112.4 18.2 2.7e-32 112.1 18.2 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CDK99562.1 - 2.3e-22 78.9 0.4 2.3e-22 78.9 0.4 1.9 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter Doppel PF11466.8 CDK99562.1 - 0.39 10.4 4.1 7.1 6.4 0.3 2.7 2 0 0 2 2 2 0 Prion-like protein Doppel OEP PF02321.18 CDK99565.1 - 5.6e-06 26.3 0.1 5.6e-06 26.3 0.1 1.9 2 0 0 2 2 2 1 Outer membrane efflux protein FliMN_C PF01052.20 CDK99565.1 - 0.0083 16.1 0.0 0.027 14.5 0.1 1.8 2 0 0 2 2 2 1 Type III flagellar switch regulator (C-ring) FliN C-term LppA PF16708.5 CDK99565.1 - 0.18 11.8 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipoprotein confined to pathogenic Mycobacterium DDE_3 PF13358.6 CDK99566.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK99566.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDK99567.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK99567.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK99567.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK99567.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK99567.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK99567.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain PIN_3 PF13470.6 CDK99569.1 - 7.8e-24 84.7 0.0 9.2e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 PIN domain PIN PF01850.21 CDK99569.1 - 4.6e-06 27.2 0.1 2.5e-05 24.8 0.1 1.9 1 1 0 1 1 1 1 PIN domain Transposase_mut PF00872.18 CDK99571.1 - 2.2e-22 79.5 0.0 2.6e-22 79.2 0.0 1.0 1 0 0 1 1 1 1 Transposase, Mutator family SpoIIID PF12116.8 CDK99571.1 - 0.093 12.8 0.0 0.16 12.1 0.0 1.3 1 1 0 1 1 1 0 Stage III sporulation protein D Transposase_mut PF00872.18 CDK99572.1 - 2.6e-62 210.9 0.2 3e-62 210.7 0.2 1.0 1 0 0 1 1 1 1 Transposase, Mutator family MULE PF10551.9 CDK99572.1 - 6.3e-06 26.5 0.0 1.5e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain Creatininase PF02633.14 CDK99572.1 - 0.0018 17.8 0.1 0.0022 17.5 0.1 1.2 1 0 0 1 1 1 1 Creatinine amidohydrolase DDE_Tnp_ISL3 PF01610.17 CDK99572.1 - 0.043 13.5 0.1 2.7 7.6 0.0 2.1 1 1 1 2 2 2 0 Transposase DUF3102 PF11300.8 CDK99573.1 - 0.0036 17.6 0.2 0.017 15.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3102) CbiA PF01656.23 CDK99574.1 - 8.5e-11 42.0 0.0 1.1e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 CDK99574.1 - 2.8e-10 40.0 0.4 5.7e-08 32.4 0.4 2.1 1 1 0 1 1 1 1 ATPase MipZ ParA PF10609.9 CDK99574.1 - 5.4e-10 39.1 0.6 3.3e-06 26.7 0.1 2.1 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase AAA_31 PF13614.6 CDK99574.1 - 7.2e-10 39.1 0.4 3.9e-07 30.2 0.1 2.2 1 1 1 2 2 2 2 AAA domain ArsA_ATPase PF02374.15 CDK99574.1 - 0.0029 16.9 0.7 0.04 13.1 0.1 2.0 1 1 1 2 2 2 1 Anion-transporting ATPase VirC1 PF07015.11 CDK99574.1 - 0.0047 16.2 0.0 0.011 15.1 0.0 1.7 1 1 0 1 1 1 1 VirC1 protein CBP_BcsQ PF06564.12 CDK99574.1 - 0.031 13.8 0.3 0.31 10.5 0.1 2.0 1 1 1 2 2 2 0 Cellulose biosynthesis protein BcsQ CLP1_P PF16575.5 CDK99574.1 - 0.18 11.5 0.0 0.66 9.7 0.0 1.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DDE_Tnp_IS66 PF03050.14 CDK99577.1 - 3.6e-87 292.4 0.0 4.6e-87 292.1 0.0 1.1 1 0 0 1 1 1 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK99577.1 - 2.9e-11 43.4 0.0 6.6e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 IS66 C-terminal element NTase_sub_bind PF08780.11 CDK99577.1 - 0.17 11.9 0.1 0.29 11.1 0.1 1.3 1 0 0 1 1 1 0 Nucleotidyltransferase substrate binding protein like DDE_Tnp_IS66 PF03050.14 CDK99578.1 - 2.3e-53 181.5 0.1 3e-53 181.1 0.1 1.1 1 0 0 1 1 1 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK99578.1 - 9.5e-19 67.3 0.1 1.8e-18 66.5 0.1 1.5 1 0 0 1 1 1 1 IS66 C-terminal element Bombinin PF05298.11 CDK99578.1 - 0.13 11.9 0.0 0.27 10.9 0.0 1.4 1 1 0 1 1 1 0 Bombinin Fib_alpha PF08702.10 CDK99579.1 - 0.01 16.0 2.2 0.019 15.1 2.2 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family MAD PF05557.13 CDK99579.1 - 0.14 10.5 15.3 0.046 12.1 8.3 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein GAS PF13851.6 CDK99579.1 - 0.24 10.7 8.1 1.1 8.6 7.0 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Golgin_A5 PF09787.9 CDK99579.1 - 1.9 7.9 14.4 2.3 7.6 12.3 1.8 1 1 0 1 1 1 0 Golgin subfamily A member 5 DivIC PF04977.15 CDK99579.1 - 5.1 6.9 15.5 0.94 9.3 0.8 3.3 1 1 1 3 3 3 0 Septum formation initiator DAGK_cat PF00781.24 CDK99580.1 - 8.3e-13 48.1 0.2 1.1e-12 47.6 0.2 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain MCR PF18509.1 CDK99581.1 - 6.4e-15 54.4 23.9 1.8e-09 37.0 4.6 2.8 3 0 0 3 3 3 2 Magnetochrome domain Paired_CXXCH_1 PF09699.10 CDK99581.1 - 0.014 15.2 1.4 1.9 8.3 0.0 2.2 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Cation_efflux PF01545.21 CDK99583.1 - 4.8e-41 140.7 11.7 5.8e-41 140.4 11.7 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CDK99583.1 - 4.4e-09 36.3 0.1 6.8e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter HTH_17 PF12728.7 CDK99584.1 - 4.7e-07 29.9 0.0 8.7e-07 29.0 0.0 1.4 2 0 0 2 2 2 1 Helix-turn-helix domain UPF0175 PF03683.13 CDK99584.1 - 0.0053 16.4 0.0 0.0073 16.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0175) MerR_1 PF13411.6 CDK99584.1 - 0.095 12.8 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 MerR HTH family regulatory protein LemA PF04011.12 CDK99585.1 - 7.9e-24 84.2 0.0 2.7e-23 82.5 0.0 1.9 1 1 1 2 2 2 1 LemA family TPR_2 PF07719.17 CDK99586.1 - 5.6e-20 69.8 0.0 0.00016 21.5 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDK99586.1 - 5.1e-19 67.2 0.0 3.3e-06 26.7 0.0 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 CDK99586.1 - 1.4e-17 63.9 0.1 1.5e-07 31.8 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDK99586.1 - 1.9e-17 63.6 0.1 1.9e-08 34.8 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDK99586.1 - 8.9e-17 59.8 0.0 0.00052 20.0 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDK99586.1 - 6.4e-15 54.6 0.3 0.0052 17.5 0.0 4.8 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDK99586.1 - 4.3e-13 49.4 0.1 0.00011 22.5 0.0 4.1 3 2 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDK99586.1 - 3.6e-12 45.8 0.0 0.0057 16.3 0.0 4.4 2 1 2 4 4 4 4 TPR repeat TPR_7 PF13176.6 CDK99586.1 - 6.5e-12 44.6 0.0 0.0036 17.2 0.0 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 CDK99586.1 - 3.9e-09 36.1 1.5 1.5 8.8 0.1 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDK99586.1 - 8.2e-09 35.6 0.0 0.00012 22.2 0.0 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CDK99586.1 - 1e-08 35.0 0.0 0.0022 18.2 0.0 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDK99586.1 - 1.5e-08 34.8 0.0 0.51 11.1 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF3856 PF12968.7 CDK99586.1 - 3.5e-06 27.1 0.6 0.052 13.6 0.0 3.2 2 1 0 2 2 2 2 Domain of Unknown Function (DUF3856) TPR_20 PF14561.6 CDK99586.1 - 1.6e-05 25.2 0.0 0.24 11.7 0.0 3.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDK99586.1 - 2.8e-05 24.2 0.1 7.8 6.7 0.0 3.8 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 CDK99586.1 - 0.0003 21.1 0.0 7.5 7.5 0.0 4.2 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDK99586.1 - 0.0084 15.4 0.0 0.17 11.1 0.0 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 CDK99586.1 - 0.013 15.5 0.0 1.9 8.6 0.0 3.3 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 CDK99586.1 - 0.057 13.7 0.1 27 5.3 0.0 4.0 4 0 0 4 4 4 0 PPR repeat BTAD PF03704.17 CDK99586.1 - 0.09 13.2 0.0 0.33 11.4 0.0 1.8 2 0 0 2 2 2 0 Bacterial transcriptional activator domain MCR PF18509.1 CDK99587.1 - 7.8e-13 47.8 4.9 3.6e-09 36.0 1.1 2.4 2 0 0 2 2 2 2 Magnetochrome domain PDZ_2 PF13180.6 CDK99587.1 - 0.00011 22.4 0.0 0.00018 21.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDK99587.1 - 0.0011 18.7 0.0 0.0021 17.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_1 PF12812.7 CDK99587.1 - 0.0079 16.2 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 PDZ-like domain TauE PF01925.19 CDK99588.1 - 2.2e-34 119.1 33.4 2.2e-34 119.1 33.4 2.2 2 0 0 2 2 2 1 Sulfite exporter TauE/SafE Trypsin_2 PF13365.6 CDK99588.1 - 2e-15 58.0 0.9 2e-15 58.0 0.9 2.2 2 0 0 2 2 2 1 Trypsin-like peptidase domain ATP-synt_J PF04911.12 CDK99588.1 - 0.41 10.2 1.6 1.5 8.5 0.3 2.7 2 0 0 2 2 2 0 ATP synthase j chain CitMHS PF03600.16 CDK99589.1 - 1.8e-27 96.4 36.9 5.6e-27 94.7 36.8 1.8 1 1 0 1 1 1 1 Citrate transporter Cation_efflux PF01545.21 CDK99590.1 - 2.3e-40 138.5 12.3 2.8e-40 138.2 12.3 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CDK99590.1 - 6.5e-16 58.2 0.5 1e-15 57.6 0.5 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter LapA_dom PF06305.11 CDK99591.1 - 0.0013 18.5 1.0 0.0013 18.5 1.0 2.0 1 1 1 2 2 2 1 Lipopolysaccharide assembly protein A domain Gram_pos_anchor PF00746.21 CDK99591.1 - 5.3 7.1 6.8 3.9 7.5 0.2 2.5 2 0 0 2 2 2 0 LPXTG cell wall anchor motif MreB_Mbl PF06723.13 CDK99592.1 - 5.8e-23 81.2 0.0 7.1e-23 80.9 0.0 1.0 1 0 0 1 1 1 1 MreB/Mbl protein Actin PF00022.19 CDK99592.1 - 3.1e-10 39.2 0.0 2.3e-07 29.8 0.0 2.1 1 1 0 2 2 2 2 Actin FtsA PF14450.6 CDK99592.1 - 0.00046 20.6 0.1 0.018 15.4 0.0 2.5 2 0 0 2 2 2 1 Cell division protein FtsA HSP70 PF00012.20 CDK99592.1 - 0.0052 15.0 0.4 0.089 11.0 0.2 2.6 2 1 0 2 2 2 1 Hsp70 protein StbA PF06406.11 CDK99592.1 - 0.074 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 StbA protein ALP_N PF17989.1 CDK99592.1 - 0.18 12.0 0.0 0.48 10.6 0.0 1.8 1 1 0 1 1 1 0 Actin like proteins N terminal domain MCR PF18509.1 CDK99594.1 - 3.7e-47 157.5 23.6 5e-16 58.0 2.6 3.7 3 0 0 3 3 3 3 Magnetochrome domain Trypsin_2 PF13365.6 CDK99594.1 - 4.2e-29 102.4 1.9 1.4e-28 100.7 1.9 2.0 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_6 PF17820.1 CDK99594.1 - 4.5e-27 93.7 3.7 9.2e-15 54.2 0.1 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 CDK99594.1 - 3.9e-26 91.2 0.0 2.2e-14 53.5 0.0 2.8 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 CDK99594.1 - 2.5e-20 72.6 0.2 9.6e-09 35.5 0.1 2.7 2 0 0 2 2 2 2 PDZ domain Trypsin PF00089.26 CDK99594.1 - 1e-15 58.1 0.2 2.1e-15 57.2 0.2 1.4 1 0 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.6 CDK99594.1 - 6.6e-05 22.8 0.1 0.025 14.6 0.0 2.5 2 0 0 2 2 2 1 Tricorn protease PDZ domain Cytochrome_CBB3 PF13442.6 CDK99594.1 - 0.00025 21.3 7.9 0.88 9.9 0.4 3.6 1 1 2 3 3 3 2 Cytochrome C oxidase, cbb3-type, subunit III PDZ_1 PF12812.7 CDK99594.1 - 0.0014 18.6 0.0 0.0068 16.4 0.0 2.1 2 0 0 2 2 2 1 PDZ-like domain CCP_MauG PF03150.14 CDK99594.1 - 0.003 18.2 3.5 3.6 8.2 0.1 3.3 2 1 1 3 3 3 1 Di-haem cytochrome c peroxidase Peptidase_S46 PF10459.9 CDK99594.1 - 0.0058 15.3 0.4 2.1 6.9 0.2 2.1 2 0 0 2 2 2 2 Peptidase S46 Paired_CXXCH_1 PF09699.10 CDK99594.1 - 0.0082 15.9 5.3 1.6 8.5 1.8 3.1 2 1 1 3 3 3 2 Doubled CXXCH motif (Paired_CXXCH_1) Peptidase_S29 PF02907.15 CDK99594.1 - 0.0096 15.7 0.5 0.026 14.2 0.0 2.0 2 0 0 2 2 1 1 Hepatitis C virus NS3 protease Peptidase_S55 PF05580.12 CDK99594.1 - 0.054 13.4 0.3 0.11 12.5 0.3 1.4 1 0 0 1 1 1 0 SpoIVB peptidase S55 Cytochrome_C7 PF14522.6 CDK99594.1 - 0.13 12.3 8.2 3.1 7.9 8.6 2.6 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c C1_1 PF00130.22 CDK99594.1 - 0.16 11.9 0.9 7.8 6.5 0.2 2.7 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Cytochrom_c3_2 PF14537.6 CDK99594.1 - 0.22 12.0 9.6 2.5 8.6 2.4 2.6 1 1 0 1 1 1 0 Cytochrome c3 DUF1924 PF09086.11 CDK99594.1 - 0.4 11.1 1.8 93 3.5 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1924) PSCyt3 PF07627.11 CDK99594.1 - 0.46 10.8 11.7 0.64 10.3 0.3 3.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1588) Cytochrom_C PF00034.21 CDK99594.1 - 0.87 10.8 11.4 14 6.9 0.7 3.5 1 1 2 3 3 3 0 Cytochrome c DUF4131 PF13567.6 CDK99595.1 - 0.036 13.7 1.3 0.035 13.7 1.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Phage_holin_3_6 PF07332.11 CDK99595.1 - 0.14 12.2 5.3 0.16 12.0 5.3 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III SLATT_6 PF18169.1 CDK99595.1 - 0.17 11.5 0.6 0.19 11.3 0.6 1.0 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 Tetraspanin PF00335.20 CDK99595.1 - 0.22 11.2 0.4 0.22 11.2 0.4 1.0 1 0 0 1 1 1 0 Tetraspanin family PEP-CTERM PF07589.11 CDK99595.1 - 1.6 9.0 6.9 5.3 7.3 2.1 2.3 2 0 0 2 2 2 0 PEP-CTERM motif FixS PF03597.15 CDK99595.1 - 3.7 7.3 11.6 3.9 7.3 4.4 2.3 2 0 0 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type MFS_1 PF07690.16 CDK99596.1 - 3.4e-26 92.0 58.0 1.5e-13 50.4 21.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CDK99596.1 - 1.7e-11 43.3 29.9 2.6e-11 42.7 29.9 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein Sugar_tr PF00083.24 CDK99596.1 - 6.1e-05 22.1 7.1 6.1e-05 22.1 7.1 3.1 3 1 1 4 4 4 2 Sugar (and other) transporter OATP PF03137.20 CDK99596.1 - 0.83 7.9 4.5 0.86 7.8 1.3 2.4 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF445 PF04286.12 CDK99597.1 - 5.2e-85 286.5 0.0 5.9e-85 286.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF445) AurF PF11583.8 CDK99597.1 - 0.009 15.3 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 P-aminobenzoate N-oxygenase AurF DDE_Tnp_1 PF01609.21 CDK99598.1 - 3e-17 63.0 0.0 3.4e-17 62.8 0.0 1.0 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_2 PF13586.6 CDK99598.1 - 3.8e-17 62.4 0.1 5.3e-17 62.0 0.1 1.2 1 0 0 1 1 1 1 Transposase DDE domain DUF4096 PF13340.6 CDK99600.1 - 7.1e-26 90.2 0.1 9.4e-26 89.8 0.1 1.1 1 0 0 1 1 1 1 Putative transposase of IS4/5 family (DUF4096) DUF4096 PF13340.6 CDK99601.1 - 0.0055 16.9 0.1 0.0071 16.5 0.1 1.3 1 0 0 1 1 1 1 Putative transposase of IS4/5 family (DUF4096) Hemerythrin PF01814.23 CDK99602.1 - 1.3e-11 45.3 1.9 1.4e-11 45.1 1.9 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Hemerythrin PF01814.23 CDK99603.1 - 4.5e-11 43.5 0.0 1.1e-10 42.3 0.0 1.7 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Response_reg PF00072.24 CDK99603.1 - 0.0034 17.5 0.0 0.033 14.3 0.0 2.3 2 0 0 2 2 2 1 Response regulator receiver domain rve PF00665.26 CDK99604.1 - 8.8e-13 48.5 0.0 1.6e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain MerR-DNA-bind PF09278.11 CDK99604.1 - 1.9e-08 34.7 2.5 3.9e-08 33.7 2.5 1.5 1 0 0 1 1 1 1 MerR, DNA binding HTH_23 PF13384.6 CDK99604.1 - 0.0053 16.5 0.2 0.054 13.3 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 CDK99604.1 - 0.025 14.7 0.0 0.086 13.0 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 CDK99604.1 - 0.099 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 DDE_3 PF13358.6 CDK99605.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK99605.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDK99606.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK99606.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK99606.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK99606.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK99606.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK99606.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain SBP_bac_6 PF13343.6 CDK99607.1 - 1.4e-23 83.6 0.1 1.7e-23 83.3 0.1 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 CDK99607.1 - 8e-17 61.9 0.2 9.5e-17 61.7 0.2 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CDK99607.1 - 1.2e-14 55.0 0.1 1.7e-14 54.5 0.1 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CDK99607.1 - 2.2e-11 44.0 0.3 3e-11 43.5 0.3 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_3 PF00497.20 CDK99607.1 - 0.075 12.4 0.1 0.18 11.2 0.1 1.6 1 1 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 HMG-CoA_red PF00368.18 CDK99608.1 - 0.53 9.2 5.8 0.65 8.9 5.8 1.1 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A reductase DUF4870 PF09685.10 CDK99610.1 - 0.035 14.2 1.2 0.046 13.8 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) Mitofilin PF09731.9 CDK99613.1 - 0.07 12.0 0.1 0.07 12.0 0.1 1.5 2 0 0 2 2 2 0 Mitochondrial inner membrane protein HemY_N PF07219.13 CDK99614.1 - 5.5e-14 52.3 7.6 9.7e-14 51.5 0.7 3.3 3 0 0 3 3 3 1 HemY protein N-terminus TPR_19 PF14559.6 CDK99614.1 - 0.0015 19.0 3.8 1.6 9.3 0.1 3.3 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDK99614.1 - 0.01 15.9 3.9 0.024 14.8 2.9 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat LapA_dom PF06305.11 CDK99614.1 - 0.15 11.8 0.2 0.32 10.8 0.2 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain TPR_2 PF07719.17 CDK99614.1 - 0.17 12.1 0.6 1.3 9.3 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat HTH_28 PF13518.6 CDK99615.1 - 0.0011 19.1 0.0 0.0017 18.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_psq PF05225.16 CDK99615.1 - 0.0047 16.6 0.0 0.0058 16.3 0.0 1.2 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_Tnp_1_2 PF13022.6 CDK99615.1 - 0.008 16.3 0.0 0.0088 16.2 0.0 1.0 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase PsiA PF06952.11 CDK99615.1 - 0.069 12.4 0.0 0.081 12.2 0.0 1.1 1 0 0 1 1 1 0 PsiA protein HTH_Tnp_1 PF01527.20 CDK99615.1 - 0.12 12.8 0.0 0.12 12.7 0.0 1.1 1 0 0 1 1 1 0 Transposase HTH_23 PF13384.6 CDK99615.1 - 0.13 12.1 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Pentapeptide PF00805.22 CDK99616.1 - 1.6e-38 129.9 36.2 3.4e-11 42.6 5.5 5.6 1 1 2 5 5 5 5 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 CDK99616.1 - 6.5e-21 74.3 0.0 1.3e-07 31.7 0.0 2.9 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 CDK99616.1 - 2.1e-19 69.4 0.1 5.7e-07 29.6 0.7 4.4 2 2 2 4 4 4 4 Pentapeptide repeats (9 copies) ALF PF03752.13 CDK99618.1 - 0.24 11.4 2.6 4.8 7.2 0.1 3.0 3 0 0 3 3 3 0 Short repeats of unknown function Hemerythrin PF01814.23 CDK99619.1 - 6.5e-09 36.5 1.9 7.6e-09 36.3 1.9 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Response_reg PF00072.24 CDK99621.1 - 0.00014 22.0 0.3 0.0019 18.4 0.1 2.7 2 1 0 2 2 2 1 Response regulator receiver domain SesA PF17107.5 CDK99621.1 - 0.016 15.4 0.1 0.032 14.4 0.1 1.5 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases CorA PF01544.18 CDK99621.1 - 0.016 14.5 1.7 0.025 13.9 1.7 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DDE_5 PF13546.6 CDK99623.1 - 4.2e-97 324.8 6.1 5.6e-97 324.4 6.1 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1 PF01609.21 CDK99623.1 - 5.5e-15 55.6 0.0 8.8e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Transposase DDE domain DUF4096 PF13340.6 CDK99624.1 - 4.7e-26 90.8 2.1 6.5e-26 90.4 2.1 1.2 1 0 0 1 1 1 1 Putative transposase of IS4/5 family (DUF4096) DDE_Tnp_1_2 PF13586.6 CDK99625.1 - 6.6e-16 58.5 0.0 7.8e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1 PF01609.21 CDK99625.1 - 4.7e-12 46.0 0.5 4.9e-08 32.9 0.0 2.0 1 1 1 2 2 2 2 Transposase DDE domain DDE_Tnp_1_3 PF13612.6 CDK99625.1 - 5.4e-05 23.2 0.0 6.6e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Transposase DDE domain DDE_5 PF13546.6 CDK99625.1 - 0.017 14.5 0.0 0.022 14.1 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF2384 PF09722.10 CDK99627.1 - 2.5e-11 43.4 0.2 4.1e-11 42.7 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2384) SbsC_C PF18058.1 CDK99627.1 - 0.14 12.3 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 SbsC C-terminal domain DpnII-MboI PF18742.1 CDK99628.1 - 3.3e-41 140.4 0.0 8e-41 139.1 0.0 1.7 2 0 0 2 2 2 1 REase_DpnII-MboI MDMPI_N PF11716.8 CDK99630.1 - 0.073 13.8 4.6 3.2 8.4 0.1 2.8 3 0 0 3 3 3 0 Mycothiol maleylpyruvate isomerase N-terminal domain Arm-DNA-bind_3 PF13356.6 CDK99631.1 - 1.2e-13 51.2 0.1 3e-13 49.9 0.1 1.7 1 0 0 1 1 1 1 Arm DNA-binding domain Phage_integrase PF00589.22 CDK99631.1 - 1.2e-11 44.7 0.0 8.9e-11 41.9 0.0 2.2 1 1 0 1 1 1 1 Phage integrase family SNase PF00565.17 CDK99633.1 - 1e-08 35.6 0.0 1.1e-08 35.5 0.0 1.1 1 0 0 1 1 1 1 Staphylococcal nuclease homologue RITA PF17066.5 CDK99633.1 - 0.083 12.5 0.0 0.089 12.4 0.0 1.0 1 0 0 1 1 1 0 RBPJ-interacting and tubulin associated protein Ribosomal_S20p PF01649.18 CDK99635.1 - 0.0096 16.5 0.4 0.14 12.8 0.3 2.0 1 1 1 2 2 2 2 Ribosomal protein S20 Cas_Cas1 PF01867.16 CDK99635.1 - 0.1 11.8 0.8 0.1 11.7 0.8 1.1 1 0 0 1 1 1 0 CRISPR associated protein Cas1 Peptidase_M48 PF01435.18 CDK99638.1 - 7.7e-09 35.6 0.0 1.2e-08 34.9 0.0 1.3 1 1 0 1 1 1 1 Peptidase family M48 Peptidase_M78 PF06114.13 CDK99638.1 - 0.0023 17.9 1.9 0.018 15.0 1.9 2.1 1 1 0 1 1 1 1 IrrE N-terminal-like domain DUF45 PF01863.17 CDK99638.1 - 0.0029 17.7 0.0 0.0042 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF45 DUF2852 PF11014.8 CDK99638.1 - 0.064 13.4 0.2 0.099 12.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) BSP PF04450.12 CDK99638.1 - 0.086 12.6 0.1 0.16 11.7 0.0 1.5 2 0 0 2 2 2 0 Peptidase of plants and bacteria MqsR_toxin PF15723.5 CDK99639.1 - 5e-27 94.1 0.0 5.7e-27 93.9 0.0 1.0 1 0 0 1 1 1 1 Motility quorum-sensing regulator, toxin of MqsA MqsA_antitoxin PF15731.5 CDK99640.1 - 3.8e-31 107.9 0.0 4.7e-31 107.6 0.0 1.0 1 0 0 1 1 1 1 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_31 PF13560.6 CDK99640.1 - 0.00048 20.4 0.1 0.00081 19.7 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 CDK99640.1 - 0.016 15.3 0.1 0.024 14.7 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix Abhydrolase_5 PF12695.7 CDK99640.1 - 0.031 14.0 0.0 0.042 13.6 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family Resolvase PF00239.21 CDK99642.1 - 2.2e-22 79.7 1.1 2.9e-22 79.4 0.1 1.7 2 0 0 2 2 2 1 Resolvase, N terminal domain Recombinase PF07508.13 CDK99642.1 - 3.9e-20 72.2 0.0 7.8e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Recombinase Zn_ribbon_recom PF13408.6 CDK99642.1 - 0.1 13.2 1.9 0.22 12.0 1.9 1.6 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Peptidase_S24 PF00717.23 CDK99643.1 - 9.7e-15 54.3 0.0 1.4e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase S24-like IMS PF00817.20 CDK99644.1 - 1.3e-34 119.3 0.0 3.7e-34 117.9 0.0 1.7 2 0 0 2 2 2 1 impB/mucB/samB family DUF4113 PF13438.6 CDK99644.1 - 1.2e-18 66.9 0.0 2.5e-18 65.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4113) IMS_C PF11799.8 CDK99644.1 - 4.3e-10 40.3 0.0 1.1e-09 39.0 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CDK99644.1 - 0.017 15.4 0.0 0.04 14.2 0.0 1.6 1 0 0 1 1 1 0 IMS family HHH motif Phage_integrase PF00589.22 CDK99645.1 - 7.1e-40 136.6 0.3 9.9e-40 136.1 0.3 1.2 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_4 PF13495.6 CDK99645.1 - 2.3e-15 56.8 0.0 6.7e-15 55.3 0.0 1.8 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 CDK99645.1 - 4.2e-10 39.8 1.5 1.1e-09 38.5 0.1 2.4 3 1 0 3 3 3 1 Phage integrase, N-terminal SAM-like domain Phage_integr_3 PF16795.5 CDK99645.1 - 0.055 13.4 0.1 0.25 11.2 0.0 2.0 2 0 0 2 2 2 0 Archaeal phage integrase Y2_Tnp PF04986.13 CDK99646.1 - 1.9e-61 207.3 0.2 2.6e-61 206.9 0.2 1.1 1 0 0 1 1 1 1 Putative transposase Zn_Tnp_IS91 PF14319.6 CDK99646.1 - 1.1e-31 108.7 0.7 1.1e-31 108.7 0.7 2.0 2 0 0 2 2 2 1 Transposase zinc-binding domain zf-IS66 PF13005.7 CDK99646.1 - 0.34 11.3 11.1 3.4 8.1 1.0 4.3 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 Anti-TRAP PF15777.5 CDK99646.1 - 1 9.4 8.6 2.9 7.9 0.2 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein OrfB_Zn_ribbon PF07282.11 CDK99646.1 - 1.1 9.2 6.9 19 5.3 0.0 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Rep_1 PF01446.17 CDK99646.1 - 6 6.3 6.6 0.52 9.7 0.5 2.1 2 0 0 2 2 2 0 Replication protein HlyD_3 PF13437.6 CDK99648.1 - 2.9e-09 37.6 0.0 1.5e-06 28.9 0.0 2.6 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDK99648.1 - 4.7e-08 32.7 0.0 1.3e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like HlyD_D23 PF16576.5 CDK99648.1 - 7.6e-07 28.6 0.0 1.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Peptidase_M50 PF02163.22 CDK99648.1 - 0.00013 21.3 4.4 0.0049 16.2 1.2 2.8 1 1 1 2 2 2 2 Peptidase family M50 HlyD_3 PF13437.6 CDK99650.1 - 4.5e-18 65.9 2.3 6.7e-12 46.1 0.0 2.4 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CDK99650.1 - 1.9e-06 27.2 0.2 3e-06 26.6 0.2 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK99650.1 - 2.2e-05 24.2 0.3 6.7e-05 22.6 0.3 1.9 1 0 0 1 1 1 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK99650.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 Biotin-requiring enzyme HlyD_3 PF13437.6 CDK99651.1 - 1.2e-15 58.1 0.6 7.3e-15 55.6 0.1 2.1 2 0 0 2 2 2 1 HlyD family secretion protein HlyD_D23 PF16576.5 CDK99651.1 - 6.6e-14 51.6 0.7 1.1e-13 51.0 0.7 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK99651.1 - 3.4e-08 33.2 0.6 0.012 15.4 0.0 2.9 3 0 0 3 3 3 2 Biotin-lipoyl like PTS_EIIA_1 PF00358.20 CDK99651.1 - 0.0065 16.2 0.0 1.3 8.8 0.0 2.5 2 0 0 2 2 2 2 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 Biotin_lipoyl PF00364.22 CDK99651.1 - 0.0069 16.2 0.0 4.1 7.3 0.0 2.6 2 0 0 2 2 2 2 Biotin-requiring enzyme OEP PF02321.18 CDK99652.1 - 3.9e-27 95.3 19.2 1.2e-15 57.8 8.4 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein He_PIG PF05345.12 CDK99653.1 - 0.00014 21.9 0.0 0.00039 20.6 0.0 1.8 1 0 0 1 1 1 1 Putative Ig domain DUF4347 PF14252.6 CDK99654.1 - 2.2e-31 108.9 2.0 3.2e-31 108.4 2.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) PQQ_3 PF13570.6 CDK99654.1 - 2.5e-08 34.1 26.5 0.87 10.2 0.2 9.1 8 1 1 9 9 9 7 PQQ-like domain PQQ PF01011.21 CDK99654.1 - 4e-05 23.3 19.2 7.1 6.7 0.1 7.8 7 0 0 7 7 7 3 PQQ enzyme repeat BNR_4 PF15892.5 CDK99654.1 - 0.037 13.4 2.0 14 4.9 0.0 4.0 2 1 1 4 4 4 0 BNR repeat-containing family member 7TMR-DISMED2 PF07696.11 CDK99655.1 - 2.8e-30 105.1 0.0 7e-30 103.8 0.0 1.6 2 0 0 2 2 2 1 7TMR-DISM extracellular 2 7TMR-DISM_7TM PF07695.11 CDK99655.1 - 3.7e-26 92.3 23.1 6.4e-26 91.5 23.1 1.4 1 0 0 1 1 1 1 7TM diverse intracellular signalling HATPase_c PF02518.26 CDK99655.1 - 1.3e-15 57.8 0.0 2.2e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK99655.1 - 0.017 15.1 0.1 0.04 14.0 0.1 1.6 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 CDK99656.1 - 3.7e-21 75.4 0.0 5.4e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDK99656.1 - 3.2e-17 62.4 0.1 3.9e-16 58.9 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal TonB_dep_Rec PF00593.24 CDK99657.1 - 3.6e-18 66.7 1.3 6.6e-18 65.8 1.4 1.3 1 1 0 1 1 1 1 TonB dependent receptor OMP_b-brl_3 PF14905.6 CDK99657.1 - 0.14 11.1 0.0 2 7.3 0.0 2.6 3 0 0 3 3 3 0 Outer membrane protein beta-barrel family Relaxase PF03432.14 CDK99659.1 - 2.5e-32 112.4 0.1 4.1e-32 111.7 0.1 1.3 1 0 0 1 1 1 1 Relaxase/Mobilisation nuclease domain CW_binding_2 PF04122.12 CDK99659.1 - 0.062 14.0 0.1 0.4 11.4 0.1 2.4 2 1 0 2 2 2 0 Putative cell wall binding repeat 2 MobL PF18555.1 CDK99659.1 - 2.4 7.3 4.6 2.8 7.1 2.4 1.8 1 1 1 2 2 2 0 MobL relaxases DUF3618 PF12277.8 CDK99660.1 - 0.031 14.5 0.1 0.15 12.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3618) NNMT_PNMT_TEMT PF01234.17 CDK99660.1 - 0.049 12.8 0.0 0.079 12.1 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family TGT_C2 PF14810.6 CDK99660.1 - 0.096 12.8 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Patch-forming domain C2 of tRNA-guanine transglycosylase WXG100 PF06013.12 CDK99660.1 - 0.12 12.6 0.6 8.3 6.7 0.3 2.4 2 0 0 2 2 2 0 Proteins of 100 residues with WXG CopC PF04234.12 CDK99660.1 - 0.13 13.3 0.0 0.16 13.0 0.0 1.4 1 1 0 1 1 1 0 CopC domain MPTase-PolyVal PF18818.1 CDK99661.1 - 5.9e-45 152.4 0.1 1.2e-44 151.4 0.1 1.5 1 0 0 1 1 1 1 Metallopeptidase superfamily domain DUF1738 PF08401.11 CDK99661.1 - 1e-31 109.7 0.1 2.4e-31 108.5 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1738) Toprim_3 PF13362.6 CDK99661.1 - 3.1e-11 43.5 0.2 3.1e-11 43.5 0.2 2.3 3 0 0 3 3 3 1 Toprim domain Toprim_4 PF13662.6 CDK99661.1 - 0.00047 20.6 0.3 0.0041 17.6 0.1 2.4 2 0 0 2 2 2 1 Toprim domain DUF3373 PF11853.8 CDK99661.1 - 0.05 12.7 0.1 0.097 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) SSB PF00436.25 CDK99663.1 - 1e-39 134.7 0.0 2.9e-20 72.2 0.0 2.0 2 0 0 2 2 2 2 Single-strand binding protein family T4SS-DNA_transf PF02534.14 CDK99664.1 - 7.7e-110 367.9 0.0 9.7e-110 367.5 0.0 1.0 1 0 0 1 1 1 1 Type IV secretory system Conjugative DNA transfer TraG-D_C PF12696.7 CDK99664.1 - 1.1e-33 115.9 0.0 2.2e-33 114.9 0.0 1.5 1 0 0 1 1 1 1 TraM recognition site of TraD and TraG TrwB_AAD_bind PF10412.9 CDK99664.1 - 5e-21 75.1 0.0 2.8e-20 72.6 0.0 1.8 1 1 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 CDK99665.1 - 1.5e-28 99.6 0.0 1.8e-28 99.4 0.0 1.0 1 0 0 1 1 1 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 CDK99665.1 - 0.0025 17.2 0.0 0.0081 15.5 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_16 PF13191.6 CDK99665.1 - 0.0036 17.7 0.0 0.0066 16.8 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 CDK99665.1 - 0.0078 16.3 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 CDK99665.1 - 0.023 15.0 0.0 0.071 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CDK99665.1 - 0.036 13.6 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SH3_4 PF06347.13 CDK99665.1 - 0.062 13.1 0.0 0.2 11.5 0.0 1.8 1 0 0 1 1 1 0 Bacterial SH3 domain AAA_29 PF13555.6 CDK99665.1 - 0.075 12.8 0.1 3 7.7 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_24 PF13479.6 CDK99665.1 - 0.079 12.7 0.0 0.27 10.9 0.0 1.8 1 1 1 2 2 2 0 AAA domain Septin PF00735.18 CDK99665.1 - 0.094 12.0 0.0 0.2 10.9 0.0 1.5 2 0 0 2 2 2 0 Septin MobB PF03205.14 CDK99665.1 - 0.11 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Mg_chelatase PF01078.21 CDK99665.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI GvpD PF07088.11 CDK99665.1 - 0.23 10.1 0.0 1.4 7.5 0.0 2.0 2 0 0 2 2 2 0 GvpD gas vesicle protein TrbI PF03743.14 CDK99667.1 - 2.4e-30 105.8 0.7 3.2e-30 105.4 0.7 1.2 1 0 0 1 1 1 1 Bacterial conjugation TrbI-like protein CagX PF03524.15 CDK99668.1 - 6.7e-25 88.1 0.0 9.1e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Conjugal transfer protein Totivirus_coat PF05518.11 CDK99668.1 - 7.3 4.5 8.0 11 3.9 8.0 1.2 1 0 0 1 1 1 0 Totivirus coat protein VirB8 PF04335.13 CDK99669.1 - 1.1e-14 54.8 0.2 1.4e-14 54.5 0.2 1.1 1 0 0 1 1 1 1 VirB8 protein TrbL PF04610.14 CDK99671.1 - 0.68 9.6 37.4 0.011 15.5 24.6 2.6 1 1 1 2 2 2 0 TrbL/VirB6 plasmid conjugal transfer protein T4SS PF07996.11 CDK99673.1 - 0.021 15.2 20.3 0.4 11.0 20.3 2.4 1 1 0 1 1 1 0 Type IV secretion system proteins TraF_2 PF13729.6 CDK99673.1 - 0.029 13.7 1.8 0.056 12.8 1.8 1.4 1 0 0 1 1 1 0 F plasmid transfer operon, TraF, protein DUF3535 PF12054.8 CDK99673.1 - 0.099 11.9 8.0 0.03 13.6 5.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3535) DASH_Dam1 PF08653.10 CDK99673.1 - 0.12 12.2 1.1 2.7 7.9 0.2 2.5 2 0 0 2 2 2 0 DASH complex subunit Dam1 Calpain_inhib PF00748.19 CDK99673.1 - 0.16 12.5 1.5 0.27 11.7 1.5 1.4 1 0 0 1 1 1 0 Calpain inhibitor NPV_P10 PF05531.12 CDK99673.1 - 1 9.9 9.4 2.2 8.8 0.5 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein AAA_19 PF13245.6 CDK99674.1 - 0.068 13.5 0.5 0.84 10.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDK99674.1 - 0.078 13.3 1.2 0.45 10.9 0.2 2.7 2 1 0 2 2 2 0 AAA ATPase domain ATPase_2 PF01637.18 CDK99674.1 - 0.13 12.2 0.0 17 5.3 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MtrE PF04206.12 CDK99675.1 - 0.019 14.3 0.6 0.023 14.0 0.6 1.1 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E TrbC PF04956.13 CDK99676.1 - 3.8e-05 23.8 6.9 5.9e-05 23.2 6.9 1.4 1 1 0 1 1 1 1 TrbC/VIRB2 family DUF4231 PF14015.6 CDK99676.1 - 0.006 17.0 0.9 0.0075 16.7 0.7 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF4231) DUF2254 PF10011.9 CDK99676.1 - 1.1 8.1 3.2 0.55 9.0 1.4 1.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2254) Myco_arth_vir_N PF09610.10 CDK99676.1 - 1.5 9.0 4.8 11 6.2 1.2 2.7 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Activator-TraM PF11657.8 CDK99677.1 - 3.6e-05 23.6 0.6 0.0028 17.5 0.0 2.1 2 0 0 2 2 2 2 Transcriptional activator TraM HAD PF12710.7 CDK99677.1 - 0.0051 17.2 0.1 0.0078 16.6 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Endotoxin_C2 PF18449.1 CDK99677.1 - 0.059 13.7 0.1 0.096 13.0 0.1 1.3 1 0 0 1 1 1 0 Delta endotoxin TSKS PF15358.6 CDK99677.1 - 0.072 11.4 0.1 0.09 11.1 0.1 1.1 1 0 0 1 1 1 0 Testis-specific serine kinase substrate CbiA PF01656.23 CDK99678.1 - 1.9e-05 24.7 0.0 2.1e-05 24.6 0.0 1.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CDK99678.1 - 0.00011 21.5 0.0 0.00021 20.6 0.0 1.4 1 0 0 1 1 1 1 Anion-transporting ATPase ParA PF10609.9 CDK99678.1 - 0.00016 21.2 0.0 0.00021 20.9 0.0 1.2 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_31 PF13614.6 CDK99678.1 - 0.001 19.0 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain PALP PF00291.25 CDK99681.1 - 3.9e-44 151.2 0.8 4.8e-44 150.9 0.8 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Arg_decarbox_C PF17944.1 CDK99683.1 - 0.0088 16.6 0.1 1.2 9.7 0.1 2.5 2 0 0 2 2 2 2 Arginine decarboxylase C-terminal helical extension GvpK PF05121.12 CDK99683.1 - 0.2 11.7 2.3 0.54 10.3 0.0 2.4 3 0 0 3 3 3 0 Gas vesicle protein K Ribosomal_60s PF00428.19 CDK99683.1 - 3 8.5 12.5 2.8 8.6 9.1 2.3 1 1 1 2 2 2 0 60s Acidic ribosomal protein EF-hand_7 PF13499.6 CDK99684.1 - 1.7e-23 82.8 0.7 5.6e-10 39.5 0.0 4.1 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 CDK99684.1 - 1.9e-23 80.4 1.9 0.00061 19.5 0.1 5.7 6 0 0 6 6 6 4 EF-hand domain EF-hand_1 PF00036.32 CDK99684.1 - 9.3e-21 71.8 6.7 4.7e-05 22.6 0.1 5.1 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.6 CDK99684.1 - 2.7e-20 72.0 6.7 0.00033 20.4 0.1 5.7 3 2 3 6 6 6 4 EF-hand domain pair EF-hand_5 PF13202.6 CDK99684.1 - 3e-18 64.4 11.4 1.5e-05 24.3 0.2 4.5 4 0 0 4 4 4 4 EF hand Dockerin_1 PF00404.18 CDK99684.1 - 7e-05 22.9 0.6 4.7 7.5 0.1 3.6 3 0 0 3 3 3 2 Dockerin type I domain SPARC_Ca_bdg PF10591.9 CDK99684.1 - 0.00023 21.4 0.4 14 6.0 0.0 4.0 3 1 1 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region NADPH_Ox PF08414.10 CDK99684.1 - 0.0025 18.1 1.2 12 6.3 0.0 3.9 4 0 0 4 4 4 1 Respiratory burst NADPH oxidase p25-alpha PF05517.12 CDK99684.1 - 0.12 12.5 0.0 45 4.2 0.0 3.2 3 0 0 3 3 3 0 p25-alpha CAP_N PF01213.19 CDK99684.1 - 0.17 11.3 5.4 0.09 12.2 0.4 2.2 1 1 1 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Sigma70_r2 PF04542.14 CDK99685.1 - 4.9e-19 67.9 0.6 9.9e-19 66.9 0.6 1.6 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 CDK99685.1 - 5.3e-09 35.6 0.8 9.4e-09 34.8 0.8 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 TPR_4 PF07721.14 CDK99685.1 - 0.028 15.0 0.6 0.028 15.0 0.6 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Metal_resist PF13801.6 CDK99687.1 - 3.6e-22 78.9 8.9 4.3e-22 78.6 8.9 1.1 1 0 0 1 1 1 1 Heavy-metal resistance NADH_dh_m_C1 PF15088.6 CDK99688.1 - 0.055 13.1 0.1 0.092 12.4 0.1 1.3 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Cyt_c_ox_IV PF12270.8 CDK99688.1 - 0.091 12.9 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV MutL_C PF08676.11 CDK99689.1 - 2.6e-47 160.3 0.0 4.2e-47 159.6 0.0 1.3 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 CDK99689.1 - 2.5e-35 120.7 0.0 3.6e-35 120.2 0.0 1.2 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CDK99689.1 - 2.4e-10 40.4 0.0 4.2e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDK99689.1 - 2.1e-06 28.2 0.0 3.9e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FlbT PF07378.11 CDK99690.1 - 3e-40 137.2 0.1 3.5e-40 137.0 0.1 1.1 1 0 0 1 1 1 1 Flagellar protein FlbT PhaP_Bmeg PF09602.10 CDK99690.1 - 0.017 15.1 1.1 0.038 13.9 1.3 1.5 1 1 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Terminase_4 PF05119.12 CDK99690.1 - 0.021 15.2 0.2 0.089 13.2 0.0 1.9 2 0 0 2 2 2 0 Phage terminase, small subunit DSBA PF01323.20 CDK99691.1 - 1.1e-38 132.9 0.0 1.2e-38 132.8 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain adh_short PF00106.25 CDK99692.1 - 1.8e-31 109.2 0.1 2.1e-31 108.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDK99692.1 - 1.1e-26 93.9 0.4 1.3e-26 93.6 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase RmlD_sub_bind PF04321.17 CDK99692.1 - 6.6e-05 22.1 0.0 0.0001 21.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 CDK99692.1 - 0.0028 17.6 1.3 0.0055 16.6 1.3 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CDK99692.1 - 0.004 16.6 0.1 0.0057 16.1 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CDK99692.1 - 0.008 15.8 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family Methyltransf_11 PF08241.12 CDK99693.1 - 3.8e-18 65.9 0.2 9.2e-18 64.7 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK99693.1 - 5e-18 65.6 0.7 8.6e-18 64.9 0.3 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDK99693.1 - 5.4e-12 45.8 0.0 7.3e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK99693.1 - 7.3e-10 39.5 0.0 1.7e-09 38.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDK99693.1 - 1.6e-07 31.4 0.0 2.2e-07 30.8 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDK99693.1 - 2.4e-07 30.3 0.0 3.4e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CDK99693.1 - 8e-05 22.3 0.1 0.00012 21.6 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 CDK99693.1 - 0.0064 16.4 0.0 0.0086 16.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 CDK99693.1 - 0.055 13.5 0.0 0.082 12.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TPMT PF05724.11 CDK99693.1 - 0.07 12.8 0.0 0.14 11.8 0.0 1.5 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) 3HCDH_N PF02737.18 CDK99693.1 - 0.11 12.4 0.1 0.16 11.8 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MetW PF07021.12 CDK99693.1 - 0.21 11.2 0.0 0.47 10.0 0.0 1.6 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Pox_MCEL PF03291.16 CDK99693.1 - 0.25 10.4 0.0 0.35 9.9 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme Ribonuc_L-PSP PF01042.21 CDK99694.1 - 1.3e-26 93.0 0.4 1.5e-26 92.8 0.4 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF1491 PF07372.12 CDK99695.1 - 8.9e-29 99.9 0.0 1e-28 99.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1491) cNMP_binding PF00027.29 CDK99696.1 - 1.1e-21 76.7 0.1 2.4e-21 75.6 0.1 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 CDK99696.1 - 1.6e-14 53.6 3.5 5.9e-14 51.8 3.5 2.0 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 CDK99696.1 - 6.1e-13 48.6 6.3 8.4e-13 48.1 6.3 1.2 1 0 0 1 1 1 1 Ion transport protein DUF2721 PF11026.8 CDK99696.1 - 6.3 6.7 11.9 0.61 10.0 2.2 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF2721) Pirin PF02678.16 CDK99697.1 - 1e-32 112.3 2.6 1.3e-32 111.9 2.0 1.4 2 0 0 2 2 2 1 Pirin Pirin_C_2 PF17954.1 CDK99697.1 - 5.2e-15 55.4 0.0 1.1e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Quercetinase C-terminal cupin domain Cupin_2 PF07883.11 CDK99697.1 - 0.00074 19.2 0.5 0.0016 18.1 0.5 1.6 1 0 0 1 1 1 1 Cupin domain Hemerythrin PF01814.23 CDK99698.1 - 4.9e-18 66.0 2.8 5.5e-18 65.8 2.8 1.0 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain NIPSNAP PF07978.13 CDK99698.1 - 0.02 15.1 0.0 0.025 14.8 0.0 1.3 1 0 0 1 1 1 0 NIPSNAP Lambda_CIII PF02061.16 CDK99698.1 - 0.15 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Lambda Phage CIII Exo_endo_phos PF03372.23 CDK99700.1 - 2.4e-12 46.9 0.0 4e-12 46.2 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Hemerythrin PF01814.23 CDK99701.1 - 4e-11 43.6 3.1 4.6e-11 43.5 3.1 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Rhabdo_ncap_2 PF03216.13 CDK99701.1 - 0.055 12.9 0.0 0.066 12.7 0.0 1.0 1 0 0 1 1 1 0 Rhabdovirus nucleoprotein CheZ PF04344.13 CDK99702.1 - 6.3e-11 42.6 4.3 5.4e-09 36.3 0.1 2.8 1 1 2 3 3 3 2 Chemotaxis phosphatase, CheZ Filament PF00038.21 CDK99702.1 - 2.4e-07 30.6 2.2 4.3e-07 29.8 1.9 1.6 1 1 1 2 2 2 1 Intermediate filament protein DUF5446 PF17522.2 CDK99702.1 - 0.0021 18.2 1.7 0.0021 18.2 1.7 3.0 4 1 0 4 4 3 1 Family of unknown function (DUF5446) zf-C4H2 PF10146.9 CDK99702.1 - 0.0028 18.0 3.9 0.014 15.7 0.1 2.3 1 1 1 2 2 2 1 Zinc finger-containing protein DUF4618 PF15397.6 CDK99702.1 - 0.0078 15.7 1.7 0.021 14.2 1.7 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4618) GAS PF13851.6 CDK99702.1 - 0.029 13.7 1.0 1.1 8.6 1.4 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 CDK99702.1 - 0.043 14.3 1.6 0.063 13.7 1.1 1.6 1 1 0 1 1 1 0 Fez1 MAD PF05557.13 CDK99702.1 - 0.047 12.0 1.9 0.1 11.0 1.7 1.5 1 1 1 2 2 2 0 Mitotic checkpoint protein PspA_IM30 PF04012.12 CDK99702.1 - 0.058 13.0 7.0 0.03 13.9 3.8 1.9 1 1 1 2 2 2 0 PspA/IM30 family PriC PF07445.12 CDK99702.1 - 0.059 13.3 0.8 0.48 10.3 0.8 2.6 1 1 0 1 1 1 0 Primosomal replication protein priC TolA_bind_tri PF16331.5 CDK99702.1 - 0.061 13.4 1.0 0.39 10.8 0.4 2.6 3 1 0 3 3 2 0 TolA binding protein trimerisation TMF_TATA_bd PF12325.8 CDK99702.1 - 0.11 12.7 4.6 0.49 10.6 2.6 2.6 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding CorA PF01544.18 CDK99702.1 - 0.15 11.4 1.0 0.21 10.9 1.0 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein KASH_CCD PF14662.6 CDK99702.1 - 0.22 11.3 4.1 0.59 9.9 4.1 1.9 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Syntaxin-6_N PF09177.11 CDK99702.1 - 0.37 11.4 2.0 0.72 10.4 0.2 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF16 PF01519.16 CDK99702.1 - 0.41 11.1 4.5 15 6.1 0.4 3.3 1 1 2 3 3 3 0 Protein of unknown function DUF16 Spc7 PF08317.11 CDK99702.1 - 0.49 9.2 4.5 1.4 7.7 4.5 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 CDK99702.1 - 0.56 10.9 5.7 2.2 8.9 2.3 3.6 4 2 1 5 5 4 0 SlyX DivIC PF04977.15 CDK99702.1 - 1 9.2 6.9 4.3 7.2 0.3 3.3 4 0 0 4 4 4 0 Septum formation initiator DUF1192 PF06698.11 CDK99702.1 - 1.1 9.3 6.9 12 6.1 0.2 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) MraZ PF02381.18 CDK99703.1 - 7.2e-18 64.3 0.0 1.9e-11 43.8 0.0 2.2 2 0 0 2 2 2 2 MraZ protein, putative antitoxin-like MazE_antitoxin PF04014.18 CDK99703.1 - 0.046 13.7 0.0 0.4 10.7 0.0 2.1 2 0 0 2 2 2 0 Antidote-toxin recognition MazE, bacterial antitoxin SQS_PSY PF00494.19 CDK99703.1 - 0.056 12.9 0.0 0.082 12.4 0.0 1.2 1 0 0 1 1 1 0 Squalene/phytoene synthase Methyltransf_5 PF01795.19 CDK99704.1 - 7e-98 327.9 0.0 8e-98 327.7 0.0 1.0 1 0 0 1 1 1 1 MraW methylase family Methyltransf_25 PF13649.6 CDK99704.1 - 0.001 19.7 0.1 0.047 14.4 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDK99704.1 - 0.0012 18.7 0.0 0.26 11.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CDK99704.1 - 0.0023 18.7 0.0 0.28 11.9 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK99704.1 - 0.012 16.2 0.0 5.2 7.8 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain HHH_3 PF12836.7 CDK99704.1 - 0.18 12.1 0.1 0.44 10.8 0.1 1.6 1 1 0 1 1 1 0 Helix-hairpin-helix motif FtsL PF04999.13 CDK99705.1 - 4.8e-06 26.5 0.1 6e-06 26.2 0.1 1.1 1 0 0 1 1 1 1 Cell division protein FtsL DivIC PF04977.15 CDK99705.1 - 0.00098 18.9 0.2 0.0012 18.6 0.2 1.2 1 0 0 1 1 1 1 Septum formation initiator HemX PF04375.14 CDK99705.1 - 0.0077 15.6 0.7 0.012 14.9 0.7 1.3 1 1 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase Med9 PF07544.13 CDK99705.1 - 0.033 14.3 0.0 0.062 13.4 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 LapA_dom PF06305.11 CDK99705.1 - 0.058 13.2 0.2 0.091 12.6 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain SlyX PF04102.12 CDK99705.1 - 0.11 13.1 4.5 0.8 10.4 4.5 2.0 1 1 0 1 1 1 0 SlyX Transpeptidase PF00905.22 CDK99706.1 - 2.6e-56 191.1 0.0 3.4e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 CDK99706.1 - 4.3e-13 50.0 0.0 2.9e-12 47.3 0.0 2.0 1 1 0 1 1 1 1 Penicillin-binding Protein dimerisation domain Mur_ligase_M PF08245.12 CDK99707.1 - 1.6e-47 162.0 0.0 2.3e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CDK99707.1 - 4e-23 81.5 0.1 5.2e-22 77.9 0.0 2.5 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain Mur_ligase PF01225.25 CDK99707.1 - 2.2e-12 47.1 0.4 7.5e-12 45.4 0.0 2.1 2 0 0 2 2 2 1 Mur ligase family, catalytic domain LpxD PF04613.14 CDK99707.1 - 0.0033 17.2 0.1 0.0089 15.8 0.1 1.8 1 0 0 1 1 1 1 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD Smr PF01713.21 CDK99707.1 - 2 8.9 4.1 17 5.8 0.4 3.2 2 1 0 2 2 2 0 Smr domain Mur_ligase_M PF08245.12 CDK99708.1 - 5.6e-39 134.1 0.0 7.7e-39 133.7 0.0 1.2 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CDK99708.1 - 1.2e-12 47.9 0.1 8.2e-10 38.8 0.0 3.2 3 0 0 3 3 3 2 Mur ligase family, glutamate ligase domain Mur_ligase PF01225.25 CDK99708.1 - 3.9e-11 43.1 0.1 1.2e-10 41.6 0.1 1.9 1 0 0 1 1 1 1 Mur ligase family, catalytic domain Glycos_transf_4 PF00953.21 CDK99709.1 - 2.7e-38 131.5 14.0 2.7e-38 131.5 14.0 2.0 3 0 0 3 3 3 1 Glycosyl transferase family 4 MraY_sig1 PF10555.9 CDK99709.1 - 0.00041 19.7 2.6 0.0012 18.2 2.6 1.9 1 0 0 1 1 1 1 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 DUF3464 PF11947.8 CDK99709.1 - 3.3 7.5 8.2 0.13 12.0 0.6 2.4 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Mur_ligase_M PF08245.12 CDK99710.1 - 9.6e-28 97.5 0.0 1.5e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CDK99710.1 - 0.00018 21.7 0.1 0.00074 19.7 0.0 2.1 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain NAD_binding_2 PF03446.15 CDK99710.1 - 0.00055 20.1 0.1 0.018 15.2 0.0 2.4 3 0 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CDK99710.1 - 0.00057 19.3 0.0 0.0013 18.1 0.0 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 CDK99710.1 - 0.044 14.1 0.0 0.15 12.3 0.0 2.0 1 0 0 1 1 1 0 TrkA-N domain IlvN PF07991.12 CDK99710.1 - 0.046 13.3 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 CDK99710.1 - 0.067 13.6 0.0 0.22 12.0 0.0 1.9 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 CDK99710.1 - 0.17 11.9 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Peptidase_M17_N PF02789.17 CDK99710.1 - 0.2 11.6 2.4 0.68 9.8 0.1 2.9 3 0 0 3 3 3 0 Cytosol aminopeptidase family, N-terminal domain FTSW_RODA_SPOVE PF01098.19 CDK99711.1 - 2.1e-78 263.9 21.5 2.5e-78 263.6 21.5 1.0 1 0 0 1 1 1 1 Cell cycle protein Glyco_tran_28_C PF04101.16 CDK99712.1 - 3.3e-33 115.0 0.0 4.7e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_28 PF03033.20 CDK99712.1 - 3.7e-29 101.5 0.7 6.9e-29 100.7 0.7 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_trans_4_4 PF13579.6 CDK99712.1 - 6.4e-05 23.5 5.2 6.4e-05 23.5 5.2 2.4 2 2 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CDK99712.1 - 0.00013 22.0 0.3 0.00028 20.9 0.3 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_3 PF13528.6 CDK99712.1 - 0.00048 19.5 0.0 0.00078 18.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 1 SpoU_methylas_C PF12105.8 CDK99712.1 - 0.054 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 SpoU, rRNA methylase, C-terminal Mur_ligase PF01225.25 CDK99713.1 - 3.5e-30 104.2 0.5 8.9e-30 102.9 0.5 1.7 1 0 0 1 1 1 1 Mur ligase family, catalytic domain Mur_ligase_M PF08245.12 CDK99713.1 - 8.1e-27 94.5 0.0 1.2e-26 93.9 0.0 1.3 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CDK99713.1 - 3e-21 75.5 0.0 2e-20 72.9 0.0 2.5 3 0 0 3 3 3 1 Mur ligase family, glutamate ligase domain MurB_C PF02873.16 CDK99714.1 - 9.8e-28 96.6 0.0 2.3e-27 95.5 0.0 1.6 1 0 0 1 1 1 1 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain FAD_binding_4 PF01565.23 CDK99714.1 - 6.1e-17 61.7 2.4 1e-15 57.7 1.6 2.2 2 0 0 2 2 2 1 FAD binding domain Dala_Dala_lig_C PF07478.13 CDK99715.1 - 3.7e-39 134.4 0.0 5e-39 134.0 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Dala_Dala_lig_N PF01820.21 CDK99715.1 - 1.8e-19 70.1 0.1 1.2e-18 67.4 0.1 2.1 1 1 0 1 1 1 1 D-ala D-ala ligase N-terminus ATP-grasp_3 PF02655.14 CDK99715.1 - 2.2e-05 24.6 0.0 4.5e-05 23.6 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 CDK99715.1 - 0.00062 19.4 0.1 0.05 13.2 0.1 2.3 1 1 0 1 1 1 1 ATP-grasp domain B12-binding PF02310.19 CDK99715.1 - 0.00087 19.3 0.5 0.003 17.6 0.2 1.9 1 1 1 2 2 2 1 B12 binding domain Peripla_BP_6 PF13458.6 CDK99715.1 - 0.001 18.8 1.3 0.0013 18.5 0.5 1.5 2 0 0 2 2 2 1 Periplasmic binding protein GARS_A PF01071.19 CDK99715.1 - 0.0013 18.5 0.0 0.0032 17.3 0.0 1.6 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp PF02222.22 CDK99715.1 - 0.011 15.4 0.0 0.019 14.5 0.0 1.4 1 1 0 1 1 1 0 ATP-grasp domain NAD_binding_8 PF13450.6 CDK99715.1 - 0.039 14.2 0.0 0.18 12.1 0.1 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain RimK PF08443.11 CDK99715.1 - 0.076 12.6 0.0 0.69 9.5 0.0 2.1 1 1 0 1 1 1 0 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.6 CDK99715.1 - 0.093 12.0 0.0 1.6 7.9 0.0 2.5 3 0 0 3 3 3 0 Sugar-transfer associated ATP-grasp FtsQ PF03799.15 CDK99716.1 - 1.7e-19 70.8 0.3 1.9e-18 67.3 0.1 2.2 2 0 0 2 2 2 1 Cell division protein FtsQ POTRA_1 PF08478.10 CDK99716.1 - 1e-16 61.0 0.0 1.9e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 POTRA domain, FtsQ-type DUF2559 PF10832.8 CDK99716.1 - 0.096 12.8 0.1 19 5.5 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2559) FtsA PF14450.6 CDK99717.1 - 2.2e-33 114.7 0.1 9.8e-24 83.8 0.0 2.1 2 0 0 2 2 2 2 Cell division protein FtsA SHS2_FTSA PF02491.20 CDK99717.1 - 1.1e-22 80.2 0.4 6.4e-22 77.7 0.3 2.3 2 0 0 2 2 2 1 SHS2 domain inserted in FTSA MreB_Mbl PF06723.13 CDK99717.1 - 7.6e-12 44.7 0.6 1.1e-10 40.8 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein EutA PF06277.11 CDK99717.1 - 1.3e-06 27.6 0.1 2.2e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutA PilM_2 PF11104.8 CDK99717.1 - 2.5e-05 23.5 0.0 0.0084 15.2 0.0 3.1 3 0 0 3 3 3 1 Type IV pilus assembly protein PilM; HSP70 PF00012.20 CDK99717.1 - 0.00033 19.0 0.2 0.049 11.8 0.0 2.2 2 0 0 2 2 2 2 Hsp70 protein CBM60 PF16841.5 CDK99717.1 - 0.031 14.7 0.0 0.059 13.8 0.0 1.5 1 0 0 1 1 1 0 Ca-dependent carbohydrate-binding module xylan-binding Hydantoinase_A PF01968.18 CDK99717.1 - 0.045 13.0 0.2 0.36 10.0 0.1 2.2 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase Actin PF00022.19 CDK99717.1 - 0.065 11.8 0.1 0.82 8.2 0.0 2.4 3 0 0 3 3 3 0 Actin CT_C_D PF02682.16 CDK99717.1 - 0.096 12.4 0.3 12 5.6 0.0 2.3 2 0 0 2 2 2 0 Carboxyltransferase domain, subdomain C and D Tubulin PF00091.25 CDK99718.1 - 1.3e-41 142.9 1.6 2.7e-41 142.0 1.6 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.8 CDK99718.1 - 4.8e-40 135.8 2.3 4.8e-40 135.8 2.3 2.1 2 0 0 2 2 2 1 FtsZ family, C-terminal domain Tubulin_2 PF13809.6 CDK99718.1 - 0.0022 17.3 8.0 0.035 13.3 3.4 2.4 1 1 1 2 2 2 2 Tubulin like LpxC PF03331.13 CDK99719.1 - 1.2e-103 346.3 0.0 1.5e-103 346.0 0.0 1.0 1 0 0 1 1 1 1 UDP-3-O-acyl N-acetylglycosamine deacetylase YfiO PF13525.6 CDK99720.1 - 3.4e-57 193.4 11.5 4.5e-57 193.1 11.5 1.2 1 0 0 1 1 1 1 Outer membrane lipoprotein TPR_18 PF13512.6 CDK99720.1 - 5.1e-20 72.1 10.5 5.5e-20 72.0 7.3 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDK99720.1 - 2.1e-12 46.8 13.5 4.2e-05 23.9 0.3 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDK99720.1 - 8.2e-09 36.0 12.2 1.8e-06 28.5 0.2 4.4 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDK99720.1 - 5.6e-07 30.0 2.0 0.016 15.7 0.0 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDK99720.1 - 2.2e-05 24.2 14.2 0.21 11.8 0.1 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_21 PF09976.9 CDK99720.1 - 0.00084 19.1 6.9 0.041 13.6 0.2 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat-like domain TPR_14 PF13428.6 CDK99720.1 - 0.0053 17.5 10.8 7.1 7.7 0.1 5.0 5 1 1 6 6 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDK99720.1 - 0.0068 16.5 3.2 1.6 9.1 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDK99720.1 - 0.012 15.3 3.3 0.012 15.3 3.3 3.6 4 2 0 4 4 4 0 TPR repeat TPR_1 PF00515.28 CDK99720.1 - 0.016 15.0 16.1 3.1 7.8 0.1 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDK99720.1 - 0.024 14.9 6.8 0.68 10.3 0.3 4.4 2 2 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDK99720.1 - 0.033 14.3 0.5 1.2 9.4 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDK99720.1 - 0.12 12.8 2.2 1.5 9.3 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDK99720.1 - 0.62 10.3 8.8 0.33 11.2 0.3 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 SMC_N PF02463.19 CDK99721.1 - 1.5e-17 63.8 0.0 2.1e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDK99721.1 - 3.9e-07 30.8 0.2 1.6e-06 28.8 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 CDK99721.1 - 2.3e-06 27.7 0.0 0.0034 17.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDK99721.1 - 0.0011 18.6 0.5 0.0024 17.6 0.5 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDK99721.1 - 0.01 16.1 0.0 0.11 12.7 0.0 2.5 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 CDK99721.1 - 0.013 15.4 0.2 0.035 14.0 0.2 1.7 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 CDK99721.1 - 0.085 13.4 0.4 0.31 11.6 0.1 2.3 2 1 0 2 2 2 0 ABC transporter EAL PF00563.20 CDK99723.1 - 2.7e-12 46.8 0.0 3.9e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 EAL domain Hemerythrin PF01814.23 CDK99724.1 - 1.6e-10 41.7 4.8 1.8e-10 41.5 4.8 1.0 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Rop PF01815.16 CDK99724.1 - 0.23 11.3 2.4 0.49 10.3 1.3 2.1 2 0 0 2 2 2 0 Rop protein HycI PF01750.18 CDK99726.1 - 0.012 15.4 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase maturation protease RuvX PF03652.15 CDK99727.1 - 1e-38 132.8 0.0 1.1e-38 132.6 0.0 1.0 1 0 0 1 1 1 1 Holliday junction resolvase VARLMGL PF14383.6 CDK99727.1 - 0.49 10.0 2.2 0.89 9.1 2.2 1.4 1 0 0 1 1 1 0 DUF761-associated sequence motif CCP_MauG PF03150.14 CDK99728.1 - 1.7e-46 158.6 0.0 5.2e-42 144.0 0.0 2.1 2 0 0 2 2 2 2 Di-haem cytochrome c peroxidase Cytochrom_C PF00034.21 CDK99728.1 - 1.4e-08 35.8 0.0 0.00091 20.3 0.0 2.4 2 0 0 2 2 2 2 Cytochrome c Cytochrome_CBB3 PF13442.6 CDK99728.1 - 3.7e-05 24.0 2.2 0.012 15.9 0.5 3.2 2 1 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III DUF1924 PF09086.11 CDK99728.1 - 0.024 15.0 0.0 0.9 9.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1924) Paired_CXXCH_1 PF09699.10 CDK99728.1 - 0.039 13.7 0.5 5.9 6.7 0.1 2.3 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_C7 PF14522.6 CDK99728.1 - 0.051 13.6 0.1 3.5 7.7 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c DHOR PF06537.11 CDK99728.1 - 0.34 9.5 0.8 3.9 6.0 0.1 2.6 3 0 0 3 3 3 0 Di-haem oxidoreductase, putative peroxidase HATPase_c PF02518.26 CDK99729.1 - 3.5e-20 72.6 0.0 5.9e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 CDK99729.1 - 7.5e-18 64.7 0.0 6.4e-17 61.7 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 CDK99729.1 - 1.6e-14 54.1 0.2 4.8e-12 46.1 0.0 3.5 3 0 0 3 3 3 1 PAS fold PAS PF00989.25 CDK99729.1 - 8e-14 51.6 0.0 1.8e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_7 PF12860.7 CDK99729.1 - 1.4e-10 41.4 0.1 8.1e-09 35.7 0.0 3.3 3 1 0 3 3 3 1 PAS fold PAS_8 PF13188.7 CDK99729.1 - 1.4e-08 34.5 0.0 4.8e-08 32.8 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 CDK99729.1 - 3.3e-08 33.7 0.0 8.2e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 PAS fold HisKA PF00512.25 CDK99729.1 - 0.00015 21.8 0.0 0.00038 20.4 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 CDK99729.1 - 0.023 14.5 0.0 0.069 13.0 0.0 1.7 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CDK99729.1 - 0.081 12.8 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 GHKL domain HATPase_c_2 PF13581.6 CDK99729.1 - 0.12 12.3 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain LytTR PF04397.15 CDK99731.1 - 6.2e-15 55.2 0.0 9.1e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 LytTr DNA-binding domain PAS_4 PF08448.10 CDK99731.1 - 5.7e-05 23.3 0.1 0.00021 21.5 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDK99731.1 - 0.00095 19.1 0.0 0.0023 17.9 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_7 PF12860.7 CDK99731.1 - 0.0066 16.6 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CDK99731.1 - 0.027 14.4 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 PAS fold PAS_9 PF13426.7 CDK99731.1 - 0.15 12.3 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 PAS domain Glu-tRNAGln PF02686.15 CDK99732.1 - 3.2e-22 78.6 0.0 4e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit PLAC9 PF15205.6 CDK99732.1 - 0.058 13.8 0.1 0.084 13.3 0.1 1.2 1 0 0 1 1 1 0 Placenta-specific protein 9 Amidase PF01425.21 CDK99733.1 - 6.5e-150 500.0 0.1 7.4e-150 499.8 0.1 1.0 1 0 0 1 1 1 1 Amidase GatB_N PF02934.15 CDK99734.1 - 4e-112 374.1 0.0 5.4e-112 373.6 0.0 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 CDK99734.1 - 7.1e-50 168.7 0.2 1.2e-49 168.0 0.2 1.3 1 0 0 1 1 1 1 GatB domain NUDIX PF00293.28 CDK99736.1 - 7e-07 29.3 0.1 9.3e-07 29.0 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain PhoU_div PF01865.16 CDK99737.1 - 1.3e-29 103.1 1.4 1.5e-29 102.9 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 PHO4 PF01384.20 CDK99738.1 - 2.4e-93 312.9 36.9 6.7e-93 311.4 36.9 1.6 1 1 0 1 1 1 1 Phosphate transporter family HTH_IclR PF09339.10 CDK99738.1 - 0.13 12.1 0.1 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 IclR helix-turn-helix domain HMGL-like PF00682.19 CDK99739.1 - 2e-72 244.0 0.0 3.2e-72 243.3 0.0 1.3 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 CDK99739.1 - 2.4e-29 101.9 1.1 4.7e-29 101.0 1.1 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain GST_N_3 PF13417.6 CDK99740.1 - 3.6e-13 49.7 0.0 6.2e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDK99740.1 - 6.6e-13 48.8 0.0 1.1e-12 48.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDK99740.1 - 3.1e-11 43.4 0.0 9.4e-11 41.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDK99740.1 - 1e-10 41.6 0.0 1.4e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDK99740.1 - 1.6e-07 31.3 0.0 3.2e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CDK99740.1 - 9.3e-06 25.8 0.0 1.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Response_reg PF00072.24 CDK99742.1 - 3.3e-22 78.8 0.2 3.7e-22 78.6 0.2 1.0 1 0 0 1 1 1 1 Response regulator receiver domain GFO_IDH_MocA PF01408.22 CDK99742.1 - 0.0051 17.6 0.0 0.0068 17.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Response_reg PF00072.24 CDK99743.1 - 1.8e-27 95.7 0.0 3.4e-27 94.8 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HD PF01966.22 CDK99743.1 - 1e-18 67.7 1.2 1.3e-18 67.3 0.2 1.6 2 0 0 2 2 2 1 HD domain HD_5 PF13487.6 CDK99743.1 - 8.1e-17 61.2 0.1 2e-16 60.0 0.1 1.7 1 0 0 1 1 1 1 HD domain HATPase_c PF02518.26 CDK99744.1 - 5.5e-23 81.6 0.0 8.8e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDK99744.1 - 8.2e-23 80.7 0.0 2e-22 79.5 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CDK99744.1 - 1.4e-19 69.8 0.0 4e-19 68.4 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HPTransfase PF10090.9 CDK99744.1 - 0.076 12.8 0.1 0.25 11.2 0.0 1.9 2 0 0 2 2 2 0 Histidine phosphotransferase C-terminal domain HATPase_c_3 PF13589.6 CDK99744.1 - 0.16 11.8 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GGDEF PF00990.21 CDK99746.1 - 6.2e-33 113.8 0.0 8.9e-33 113.3 0.0 1.2 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain GRDA PF04723.14 CDK99746.1 - 0.19 11.5 0.0 0.37 10.6 0.0 1.4 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A DUF4212 PF13937.6 CDK99746.1 - 3.1 8.2 6.2 0.47 10.9 1.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4212) GGDEF PF00990.21 CDK99747.1 - 3.2e-52 176.5 0.0 3.8e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain EAL PF00563.20 CDK99748.1 - 6.7e-75 251.7 0.0 1.3e-74 250.7 0.0 1.5 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK99748.1 - 7.9e-41 139.5 0.0 1.5e-40 138.6 0.0 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_4 PF08448.10 CDK99748.1 - 2.8e-16 59.7 0.1 6.1e-10 39.3 0.0 3.2 2 1 0 2 2 2 2 PAS fold PAS_9 PF13426.7 CDK99748.1 - 1.5e-13 50.9 0.0 6.3e-10 39.2 0.0 3.2 2 1 0 2 2 2 2 PAS domain PAS PF00989.25 CDK99748.1 - 2e-12 47.1 0.1 8.6e-10 38.6 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 CDK99748.1 - 4.8e-10 39.2 0.0 4.9e-08 32.8 0.0 2.8 2 0 0 2 2 2 1 PAS domain PAS_7 PF12860.7 CDK99748.1 - 0.00066 19.8 0.1 0.053 13.7 0.0 2.9 3 0 0 3 3 3 1 PAS fold T6SS_HCP PF05638.12 CDK99748.1 - 0.063 13.7 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Type VI secretion system effector, Hcp Lac_bphage_repr PF06543.12 CDK99749.1 - 0.088 12.8 0.1 0.093 12.7 0.1 1.1 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor Terminase_GpA PF05876.12 CDK99753.1 - 1.2e-211 704.2 2.9 1.4e-211 704.0 2.9 1.0 1 0 0 1 1 1 1 Phage terminase large subunit (GpA) Lar_restr_allev PF14354.6 CDK99753.1 - 0.036 14.4 0.7 0.08 13.3 0.7 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar Zn_Tnp_IS1595 PF12760.7 CDK99753.1 - 0.038 14.0 1.3 0.26 11.3 2.2 2.0 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-HYPF PF07503.12 CDK99753.1 - 2.7 7.9 4.4 1.8 8.4 0.2 2.4 2 0 0 2 2 2 0 HypF finger PspA_IM30 PF04012.12 CDK99754.1 - 0.037 13.6 0.2 0.038 13.6 0.2 1.0 1 0 0 1 1 1 0 PspA/IM30 family Phage_portal_2 PF05136.13 CDK99755.1 - 1e-103 347.3 0.0 1.6e-103 346.7 0.0 1.3 1 0 0 1 1 1 1 Phage portal protein, lambda family Peptidase_S49 PF01343.18 CDK99756.1 - 1.1e-29 103.4 0.0 1.7e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S49 CLP_protease PF00574.23 CDK99756.1 - 0.092 12.6 0.1 2.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Clp protease HDPD PF02924.14 CDK99757.1 - 5.2e-29 100.7 3.5 5.9e-29 100.5 3.5 1.0 1 0 0 1 1 1 1 Bacteriophage lambda head decoration protein D TgMIC1 PF11476.8 CDK99757.1 - 0.028 14.2 0.2 0.042 13.6 0.2 1.3 1 0 0 1 1 1 0 Toxoplasma gondii micronemal protein 1 TgMIC1 Phage_cap_E PF03864.15 CDK99758.1 - 5.3e-93 311.8 0.3 6.3e-93 311.6 0.3 1.0 1 0 0 1 1 1 1 Phage major capsid protein E Phage_H_T_join PF05521.11 CDK99759.1 - 0.1 13.1 0.0 0.11 13.0 0.0 1.1 1 0 0 1 1 1 0 Phage head-tail joining protein Gifsy-2 PF13856.6 CDK99759.1 - 0.13 12.7 0.0 0.17 12.3 0.0 1.2 1 0 0 1 1 1 0 ATP-binding sugar transporter from pro-phage Tape_meas_lam_C PF09718.10 CDK99766.1 - 4.3e-20 71.6 1.1 4.3e-20 71.6 1.1 2.3 2 0 0 2 2 2 1 Lambda phage tail tape-measure protein (Tape_meas_lam_C) TMP_2 PF06791.13 CDK99766.1 - 1.2e-11 44.7 16.0 1.2e-11 44.7 16.0 4.4 3 2 1 4 4 4 1 Prophage tail length tape measure protein YafQ_toxin PF15738.5 CDK99767.1 - 3.2e-32 110.7 0.7 3.8e-32 110.5 0.7 1.0 1 0 0 1 1 1 1 Bacterial toxin of type II toxin-antitoxin system, YafQ ParE_toxin PF05016.15 CDK99767.1 - 9.5e-07 29.3 0.3 1.1e-06 29.2 0.3 1.1 1 0 0 1 1 1 1 ParE toxin of type II toxin-antitoxin system, parDE RelB PF04221.12 CDK99768.1 - 2e-20 72.5 0.1 2.3e-20 72.4 0.1 1.0 1 0 0 1 1 1 1 RelB antitoxin LPD7 PF18821.1 CDK99768.1 - 0.018 15.2 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 7 AAA_17 PF13207.6 CDK99770.1 - 0.066 13.6 4.1 0.76 10.2 0.4 2.4 2 0 0 2 2 2 0 AAA domain SF-assemblin PF06705.11 CDK99770.1 - 0.27 10.5 5.1 0.038 13.3 1.0 1.6 2 0 0 2 2 2 0 SF-assemblin/beta giardin ApoLp-III PF07464.11 CDK99770.1 - 0.92 9.6 6.8 3 7.9 1.2 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF4358 PF14270.6 CDK99770.1 - 1.7 9.0 6.0 0.21 11.9 1.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) RCC1 PF00415.18 CDK99772.1 - 7e-34 116.2 28.8 2.8e-12 47.1 0.5 7.7 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDK99772.1 - 3.3e-18 65.0 27.6 8.1e-06 25.5 0.1 7.5 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat DUF1833 PF08875.11 CDK99775.1 - 3.2e-69 231.2 0.0 3.6e-69 231.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1833) DUF736 PF05284.12 CDK99775.1 - 0.0048 16.8 0.0 0.056 13.3 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF736) NLPC_P60 PF00877.19 CDK99776.1 - 3.6e-06 27.0 0.0 4.3e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 NlpC/P60 family Phage-tail_3 PF13550.6 CDK99777.1 - 1.9e-25 89.6 0.0 4e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 Putative phage tail protein Lambda_tail_I PF06805.12 CDK99777.1 - 2.7e-20 72.5 0.4 8.8e-20 70.9 0.4 1.9 1 0 0 1 1 1 1 Bacteriophage lambda tail assembly protein I Glyco_hydro_19 PF00182.19 CDK99778.1 - 1.1e-10 41.8 0.1 2.8e-09 37.2 0.0 2.5 1 1 1 2 2 2 1 Chitinase class I Rep_fac-A_C PF08646.10 CDK99779.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Replication factor-A C terminal domain DUF3040 PF11239.8 CDK99779.1 - 0.25 11.6 5.9 2.1 8.7 2.2 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF3040) CitMHS PF03600.16 CDK99780.1 - 2.3e-51 174.8 29.3 3.7e-51 174.1 29.3 1.4 1 0 0 1 1 1 1 Citrate transporter E1-E2_ATPase PF00122.20 CDK99781.1 - 1.1e-48 165.1 2.0 1.1e-48 165.1 2.0 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDK99781.1 - 1.2e-38 132.6 3.7 1.2e-38 132.6 3.7 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CDK99781.1 - 5.6e-21 75.8 9.6 2.9e-20 73.5 9.6 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDK99781.1 - 8.6e-18 64.2 0.0 1.6e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CDK99781.1 - 1e-15 57.1 0.0 2.2e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CDK99781.1 - 1.4e-05 24.9 0.3 2.8e-05 24.0 0.3 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Gemini_mov PF01708.16 CDK99781.1 - 0.11 12.3 0.8 0.64 9.8 0.1 2.4 2 0 0 2 2 2 0 Geminivirus putative movement protein GGDEF PF00990.21 CDK99782.1 - 6e-45 152.9 0.1 7.6e-45 152.5 0.1 1.1 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Glyco_hydro_15 PF00723.21 CDK99783.1 - 1.4e-31 109.8 0.0 2.9e-26 92.3 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 Trehalase PF01204.18 CDK99783.1 - 0.13 11.0 0.0 1.7 7.4 0.0 2.0 2 0 0 2 2 2 0 Trehalase Trehalose_PPase PF02358.16 CDK99784.1 - 4.5e-35 120.9 0.0 6.2e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 Trehalose-phosphatase DUF4123 PF13503.6 CDK99784.1 - 0.00047 20.6 0.0 0.0047 17.4 0.0 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4123) Hydrolase_3 PF08282.12 CDK99784.1 - 0.00053 19.8 0.0 0.062 13.0 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDK99784.1 - 0.14 11.7 0.0 4 6.9 0.0 2.0 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Glyco_transf_20 PF00982.21 CDK99785.1 - 2.7e-117 392.4 0.0 3.3e-117 392.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 CdvA PF18822.1 CDK99786.1 - 0.064 13.1 0.0 0.086 12.7 0.0 1.1 1 0 0 1 1 1 0 CdvA-like coiled-coil domain PAS_3 PF08447.12 CDK99787.1 - 1.9e-49 165.9 0.2 2.9e-16 59.5 0.0 5.7 5 0 0 5 5 5 5 PAS fold CBS PF00571.28 CDK99787.1 - 2.5e-41 139.9 15.3 2.1e-11 44.1 0.2 5.8 6 0 0 6 6 6 4 CBS domain PAS PF00989.25 CDK99787.1 - 3.4e-36 123.7 0.2 1.4e-11 44.3 0.0 5.8 5 0 0 5 5 5 5 PAS fold PAS_9 PF13426.7 CDK99787.1 - 8.4e-30 103.1 0.0 3.9e-07 30.3 0.0 5.5 5 0 0 5 5 5 5 PAS domain PAS_4 PF08448.10 CDK99787.1 - 1.4e-27 96.1 13.3 3.3e-06 27.3 0.1 5.9 6 0 0 6 6 6 4 PAS fold HATPase_c PF02518.26 CDK99787.1 - 2.3e-22 79.6 0.0 7.4e-22 78.0 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_2 PF13185.6 CDK99787.1 - 3.4e-22 79.2 0.1 2.2e-21 76.6 0.1 2.5 1 0 0 1 1 1 1 GAF domain PAS_8 PF13188.7 CDK99787.1 - 5.1e-16 58.3 0.3 3.2e-09 36.6 0.0 4.1 3 0 0 3 3 3 2 PAS domain HisKA PF00512.25 CDK99787.1 - 4.1e-12 45.9 0.1 3e-11 43.2 0.1 2.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain NMT1_2 PF13379.6 CDK99790.1 - 1.7e-09 37.7 0.2 1.5e-08 34.7 0.2 2.3 1 1 1 2 2 2 1 NMT1-like family NMT1 PF09084.11 CDK99790.1 - 7.2e-08 32.6 0.0 1.2e-06 28.6 0.0 2.0 1 1 0 1 1 1 1 NMT1/THI5 like REPA_OB_2 PF16900.5 CDK99790.1 - 0.028 14.3 0.1 0.085 12.8 0.0 1.8 2 0 0 2 2 2 0 Replication protein A OB domain DUF5563 PF17718.1 CDK99790.1 - 0.098 12.2 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5563) EAL PF00563.20 CDK99791.1 - 1.1e-55 188.8 0.0 1.7e-55 188.2 0.0 1.3 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK99791.1 - 3.1e-27 95.3 0.0 7e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_4 PF08448.10 CDK99791.1 - 0.00059 20.1 0.1 0.15 12.3 0.1 3.1 2 1 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDK99791.1 - 0.0046 16.9 0.0 0.21 11.7 0.0 2.8 2 0 0 2 2 2 1 PAS domain sCache_like PF16736.5 CDK99791.1 - 0.0096 16.0 0.0 0.029 14.5 0.0 1.8 2 0 0 2 2 2 1 Single Cache-like PAS PF00989.25 CDK99791.1 - 0.032 14.2 0.0 0.34 10.9 0.0 2.4 1 1 1 2 2 2 0 PAS fold PAS_9 PF13426.7 CDK99791.1 - 0.079 13.2 0.0 3.2 8.1 0.0 3.2 2 1 0 2 2 2 0 PAS domain BORCS8 PF10167.9 CDK99793.1 - 0.0013 18.6 0.3 0.002 18.1 0.3 1.2 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 8 DZR PF12773.7 CDK99793.1 - 0.0061 16.6 0.5 0.0091 16.0 0.5 1.3 1 0 0 1 1 1 1 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 CDK99793.1 - 0.01 15.8 0.2 0.016 15.1 0.2 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.10 CDK99793.1 - 0.01 15.9 3.0 0.17 12.0 0.3 2.3 1 1 2 3 3 3 0 Zinc ribbon domain UL141 PF16758.5 CDK99793.1 - 0.011 15.4 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 0 Herpes-like virus membrane glycoprotein UL141 JAKMIP_CC3 PF16034.5 CDK99793.1 - 0.017 15.1 0.3 0.019 15.0 0.3 1.2 1 0 0 1 1 1 0 JAKMIP CC3 domain HypA PF01155.19 CDK99793.1 - 0.027 14.5 2.9 0.041 13.9 2.9 1.4 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FliG_N PF14842.6 CDK99793.1 - 0.032 14.8 1.1 0.051 14.1 1.1 1.3 1 0 0 1 1 1 0 FliG N-terminal domain Zn_Tnp_IS1595 PF12760.7 CDK99793.1 - 0.032 14.2 0.1 0.05 13.6 0.1 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain ADD_ATRX PF17981.1 CDK99793.1 - 0.033 14.1 2.3 0.32 10.9 2.1 2.1 1 1 1 2 2 2 0 Cysteine Rich ADD domain Nudix_N_2 PF14803.6 CDK99793.1 - 0.056 13.4 1.4 0.31 11.0 1.3 2.1 1 1 0 1 1 1 0 Nudix N-terminal SICA_alpha PF12887.7 CDK99793.1 - 0.06 13.2 0.1 0.071 13.0 0.1 1.1 1 0 0 1 1 1 0 SICA extracellular alpha domain ZapB PF06005.12 CDK99793.1 - 0.061 13.8 0.9 0.11 12.9 0.9 1.4 1 0 0 1 1 1 0 Cell division protein ZapB eIF-5_eIF-2B PF01873.17 CDK99793.1 - 0.064 13.1 0.1 0.089 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain found in IF2B/IF5 FUSC PF04632.12 CDK99793.1 - 0.081 11.5 0.7 0.087 11.3 0.7 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1451 PF07295.11 CDK99793.1 - 0.099 12.7 5.8 0.5 10.4 5.8 2.0 1 1 0 1 1 1 0 Zinc-ribbon containing domain PhnA_Zn_Ribbon PF08274.12 CDK99793.1 - 0.12 12.3 1.3 0.26 11.3 1.3 1.5 1 1 0 1 1 1 0 PhnA Zinc-Ribbon DUF678 PF05077.12 CDK99793.1 - 0.13 12.4 3.2 1 9.6 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF678) PHD PF00628.29 CDK99793.1 - 0.15 12.0 1.8 0.38 10.7 1.9 1.6 1 1 1 2 2 2 0 PHD-finger zf-ribbon_3 PF13248.6 CDK99793.1 - 0.41 10.1 2.7 2.7 7.5 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.13 CDK99793.1 - 0.48 10.1 2.4 1.7 8.4 2.7 1.8 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit TF_Zn_Ribbon PF08271.12 CDK99793.1 - 0.49 10.0 2.9 2.7 7.6 3.0 2.1 1 1 0 1 1 1 0 TFIIB zinc-binding zf-C4H2 PF10146.9 CDK99793.1 - 1.5 9.0 5.9 3.2 8.0 5.0 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein APG6_N PF17675.1 CDK99793.1 - 1.9 9.1 5.6 4.3 7.9 5.6 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region BLUF PF04940.12 CDK99794.1 - 6.5e-28 96.7 0.0 8.5e-28 96.3 0.0 1.2 1 0 0 1 1 1 1 Sensors of blue-light using FAD DUF1115 PF06544.12 CDK99794.1 - 0.08 13.0 0.0 5.8 7.0 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1115) HATPase_c PF02518.26 CDK99796.1 - 1.7e-24 86.4 0.0 4.6e-24 85.1 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 7TMR-DISMED2 PF07696.11 CDK99796.1 - 2.6e-17 63.1 0.0 4.5e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 7TMR-DISM extracellular 2 Response_reg PF00072.24 CDK99796.1 - 1e-15 57.9 0.0 1.9e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CDK99796.1 - 1.2e-14 54.0 1.4 9.2e-14 51.2 0.4 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain 7TMR-DISM_7TM PF07695.11 CDK99796.1 - 2.7e-11 43.7 19.1 3.9e-11 43.2 19.1 1.2 1 0 0 1 1 1 1 7TM diverse intracellular signalling HTH_18 PF12833.7 CDK99797.1 - 2.3e-23 82.2 1.3 3.8e-23 81.5 1.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Response_reg PF00072.24 CDK99797.1 - 1.4e-19 70.3 0.1 2e-19 69.8 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HTH_AraC PF00165.23 CDK99797.1 - 1.3e-13 50.7 0.0 1.5e-09 37.7 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family DUF354 PF04007.12 CDK99797.1 - 0.13 11.3 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF354) GGDEF PF00990.21 CDK99798.1 - 5e-45 153.2 0.0 9.3e-45 152.3 0.0 1.5 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain NMT1 PF09084.11 CDK99798.1 - 8e-38 130.5 0.0 1.1e-37 130.1 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like PAS_4 PF08448.10 CDK99798.1 - 4.8e-10 39.7 0.1 1.6e-09 37.9 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CDK99798.1 - 1.3e-08 35.0 0.0 3.8e-08 33.5 0.0 1.8 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 CDK99798.1 - 1.7e-08 34.4 0.0 3.1e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK99798.1 - 0.00019 21.4 0.0 0.00064 19.7 0.0 1.9 1 0 0 1 1 1 1 PAS domain NMT1_2 PF13379.6 CDK99798.1 - 0.15 11.7 0.0 12 5.5 0.0 2.1 2 0 0 2 2 2 0 NMT1-like family Lac_bphage_repr PF06543.12 CDK99800.1 - 0.097 12.7 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor SoPB_HTH PF18090.1 CDK99803.1 - 0.1 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Centromere-binding protein HTH domain Zn_ribbon_recom PF13408.6 CDK99804.1 - 2.4e-15 56.8 1.2 4e-15 56.1 1.2 1.4 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain Recombinase PF07508.13 CDK99804.1 - 5e-10 39.7 0.0 1e-09 38.7 0.0 1.6 1 0 0 1 1 1 1 Recombinase Ogr_Delta PF04606.12 CDK99804.1 - 0.18 11.8 2.5 0.4 10.7 2.5 1.6 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger Nudix_N_2 PF14803.6 CDK99806.1 - 2 8.4 5.2 13 5.8 0.0 3.0 3 0 0 3 3 3 0 Nudix N-terminal HTH_3 PF01381.22 CDK99807.1 - 0.007 16.4 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CDK99807.1 - 0.016 15.5 0.1 0.026 14.8 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Gp49 PF05973.14 CDK99808.1 - 1.9e-06 27.9 0.0 2.5e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Phage derived protein Gp49-like (DUF891) AAA_30 PF13604.6 CDK99809.1 - 2.3e-21 76.4 0.1 7.1e-21 74.8 0.1 1.7 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CDK99809.1 - 2.3e-19 69.0 0.1 5.1e-19 67.8 0.1 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CDK99809.1 - 6.1e-13 49.3 0.0 1.5e-12 48.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 CDK99809.1 - 7.1e-08 32.5 0.0 0.006 16.4 0.0 3.2 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CDK99809.1 - 0.00027 21.2 0.0 0.00053 20.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain PIF1 PF05970.14 CDK99809.1 - 0.00042 19.6 0.7 0.054 12.7 0.1 2.9 2 1 1 3 3 3 2 PIF1-like helicase AAA_16 PF13191.6 CDK99809.1 - 0.013 15.9 0.0 0.04 14.3 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain UvrD_C PF13361.6 CDK99809.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain VirE PF05272.11 CDK99810.1 - 5e-67 225.5 0.0 6.9e-67 225.0 0.0 1.2 1 0 0 1 1 1 1 Virulence-associated protein E Toprim_3 PF13362.6 CDK99810.1 - 1.4e-22 79.8 0.1 3.7e-22 78.5 0.1 1.7 1 0 0 1 1 1 1 Toprim domain Toprim_2 PF13155.6 CDK99810.1 - 0.026 15.0 0.0 0.069 13.6 0.0 1.7 1 0 0 1 1 1 0 Toprim-like zf-HC5HC2H_2 PF13832.6 CDK99815.1 - 0.13 12.4 0.3 0.19 11.9 0.3 1.2 1 0 0 1 1 1 0 PHD-zinc-finger like domain DNA_methylase PF00145.17 CDK99816.1 - 5.1e-21 75.4 0.0 6.8e-21 75.0 0.0 1.0 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase DNA_methylase PF00145.17 CDK99817.1 - 6.2e-11 42.2 0.0 6.6e-11 42.1 0.0 1.0 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase N6_N4_Mtase PF01555.18 CDK99818.1 - 5.8e-22 78.5 0.0 2e-20 73.5 0.0 2.2 1 1 0 1 1 1 1 DNA methylase ParBc PF02195.18 CDK99818.1 - 4.9e-11 42.8 0.0 1.5e-10 41.2 0.0 1.7 2 0 0 2 2 2 1 ParB-like nuclease domain UPF0020 PF01170.18 CDK99818.1 - 0.14 11.9 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DUF434 PF04256.12 CDK99819.1 - 0.092 12.4 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF434) Bac_DNA_binding PF00216.21 CDK99822.1 - 4.7e-25 87.6 0.3 5.1e-25 87.5 0.3 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein Ldh_2 PF02615.14 CDK99822.1 - 0.0021 17.2 0.0 0.0021 17.2 0.0 1.1 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Ribosomal_L12 PF00542.19 CDK99822.1 - 0.018 15.4 0.0 0.029 14.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain HU-HIG PF18291.1 CDK99822.1 - 0.043 13.9 0.0 0.047 13.8 0.0 1.1 1 0 0 1 1 1 0 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_bac_2 PF18175.1 CDK99822.1 - 0.049 13.5 0.0 0.074 12.9 0.0 1.3 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 Phe_hydrox_dim PF07976.12 CDK99822.1 - 0.054 13.5 0.0 0.054 13.5 0.0 1.1 1 0 0 1 1 1 0 Phenol hydroxylase, C-terminal dimerisation domain DUF3489 PF11994.8 CDK99823.1 - 3.7e-29 100.6 0.1 6.8e-29 99.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3489) DUF2742 PF10888.8 CDK99823.1 - 0.14 12.4 0.1 0.24 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2742) HTH_50 PF18024.1 CDK99826.1 - 0.048 13.3 0.2 0.13 11.9 0.2 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Terminase_GpA PF05876.12 CDK99827.1 - 3.5e-212 705.9 2.3 4e-212 705.7 2.3 1.0 1 0 0 1 1 1 1 Phage terminase large subunit (GpA) Lar_restr_allev PF14354.6 CDK99827.1 - 0.025 14.9 1.0 0.053 13.9 1.0 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar Zn_Tnp_IS1595 PF12760.7 CDK99827.1 - 0.048 13.7 1.5 0.33 10.9 2.4 2.0 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-HYPF PF07503.12 CDK99827.1 - 1.3 8.9 4.8 1.9 8.4 0.2 2.5 2 0 0 2 2 2 0 HypF finger PspA_IM30 PF04012.12 CDK99828.1 - 0.034 13.7 0.1 0.037 13.6 0.1 1.0 1 0 0 1 1 1 0 PspA/IM30 family Phage_portal_2 PF05136.13 CDK99829.1 - 6.2e-105 351.3 0.0 9.7e-105 350.7 0.0 1.3 1 0 0 1 1 1 1 Phage portal protein, lambda family Peptidase_S49 PF01343.18 CDK99830.1 - 1.6e-30 106.1 0.1 2.5e-30 105.5 0.1 1.2 1 0 0 1 1 1 1 Peptidase family S49 CLP_protease PF00574.23 CDK99830.1 - 0.16 11.8 0.3 2.2 8.1 0.1 2.2 1 1 1 2 2 2 0 Clp protease HDPD PF02924.14 CDK99831.1 - 2.8e-29 101.6 3.1 3.1e-29 101.4 3.1 1.0 1 0 0 1 1 1 1 Bacteriophage lambda head decoration protein D Phage_cap_E PF03864.15 CDK99832.1 - 1e-91 307.6 0.3 1.2e-91 307.4 0.3 1.0 1 0 0 1 1 1 1 Phage major capsid protein E Gifsy-2 PF13856.6 CDK99833.1 - 0.016 15.6 0.0 0.019 15.3 0.0 1.1 1 0 0 1 1 1 0 ATP-binding sugar transporter from pro-phage EAL PF00563.20 CDK99835.1 - 7.7e-68 228.6 0.0 1.6e-67 227.5 0.0 1.6 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDK99835.1 - 1.8e-37 128.6 0.0 3.8e-37 127.5 0.0 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDK99835.1 - 2.3e-16 59.9 0.0 5.4e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CDK99835.1 - 3.7e-14 52.7 0.0 9.3e-14 51.4 0.0 1.7 1 0 0 1 1 1 1 PAS fold dCache_1 PF02743.18 CDK99835.1 - 3.6e-11 43.3 0.0 1.1e-10 41.7 0.0 1.9 2 0 0 2 2 2 1 Cache domain PAS_3 PF08447.12 CDK99835.1 - 1.3e-08 35.0 0.4 1.9e-07 31.3 0.1 2.6 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDK99835.1 - 2.6e-06 27.3 0.1 2.2e-05 24.4 0.0 2.6 3 0 0 3 3 3 1 PAS domain HAMP PF00672.25 CDK99835.1 - 7.9e-05 23.0 0.6 7.9e-05 23.0 0.6 2.3 2 0 0 2 2 2 1 HAMP domain PAS_4 PF08448.10 CDK99835.1 - 0.00023 21.4 0.1 0.00094 19.4 0.1 2.2 1 0 0 1 1 1 1 PAS fold T2SSF PF00482.23 CDK99835.1 - 1 9.3 4.3 43 4.1 1.3 3.4 3 1 0 3 3 3 0 Type II secretion system (T2SS), protein F DUF3040 PF11239.8 CDK99839.1 - 0.06 13.6 3.1 0.82 10.0 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) HTH_18 PF12833.7 CDK99840.1 - 8.1e-25 86.9 0.8 1.5e-24 86.0 0.8 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CDK99840.1 - 2.3e-12 46.7 0.0 3.8e-05 23.7 0.0 2.4 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Sigma70_r3 PF04539.16 CDK99840.1 - 0.08 13.0 0.0 0.27 11.4 0.0 1.9 2 0 0 2 2 2 0 Sigma-70 region 3 HTH_28 PF13518.6 CDK99840.1 - 0.12 12.5 0.1 4.1 7.6 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_18 PF12833.7 CDK99841.1 - 8.9e-20 70.8 0.3 1.9e-19 69.7 0.3 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CDK99841.1 - 1.1e-09 38.1 0.0 0.0015 18.6 0.0 3.2 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_AsnC-type PF13404.6 CDK99841.1 - 0.15 11.9 0.9 12 5.8 0.0 2.9 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain OEP PF02321.18 CDK99843.1 - 3.7e-26 92.1 23.4 1.7e-16 60.6 11.2 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein Emaravirus_P4 PF16505.5 CDK99843.1 - 0.63 9.0 6.4 1.3 8.0 0.9 2.6 3 0 0 3 3 3 0 P4 movement protein of Emaravirus, and the 30K superfamily HlyD_3 PF13437.6 CDK99844.1 - 6.8e-15 55.7 1.6 2.3e-14 54.0 0.5 2.1 2 1 0 2 2 2 1 HlyD family secretion protein HlyD_D23 PF16576.5 CDK99844.1 - 1.4e-14 53.8 1.6 2e-14 53.3 1.6 1.1 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK99844.1 - 1.6e-05 24.7 0.9 0.012 15.4 0.0 2.9 3 0 0 3 3 3 2 Biotin-lipoyl like PTS_EIIA_1 PF00358.20 CDK99844.1 - 0.064 13.0 0.1 2 8.2 0.0 2.4 2 1 0 2 2 2 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 RbcS PF12338.8 CDK99844.1 - 0.29 11.4 1.9 20 5.5 0.2 2.9 2 0 0 2 2 2 0 Ribulose-1,5-bisphosphate carboxylase small subunit DUF4347 PF14252.6 CDK99845.1 - 1e-44 152.3 5.3 1e-44 152.3 5.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4347) BNR_4 PF15892.5 CDK99845.1 - 3.9e-06 26.4 0.1 0.15 11.4 0.0 4.1 3 1 0 3 3 3 3 BNR repeat-containing family member Rgp1 PF08737.10 CDK99845.1 - 0.053 12.7 0.1 8 5.5 0.0 2.2 2 0 0 2 2 2 0 Rgp1 NQRA_SLBB PF11973.8 CDK99845.1 - 0.1 13.3 2.6 23 5.7 0.2 3.3 2 0 0 2 2 2 0 NQRA C-terminal domain Orthopox_C10L PF07020.11 CDK99845.1 - 0.17 12.7 20.2 0.24 12.1 0.8 4.9 4 0 0 4 4 4 0 Orthopoxvirus C10L protein DUF4347 PF14252.6 CDK99846.1 - 5.6e-44 149.9 3.7 1.1e-43 148.9 3.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4347) SBBP PF06739.11 CDK99846.1 - 1.2e-20 73.2 80.7 1.1e-06 28.5 3.0 12.7 13 0 0 13 13 13 8 Beta-propeller repeat PCYCGC PF13798.6 CDK99846.1 - 0.0021 17.9 0.2 6.1 6.7 0.0 5.2 7 0 0 7 7 7 1 Protein of unknown function with PCYCGC motif DUF5122 PF17164.4 CDK99846.1 - 0.06 13.6 77.3 1.8 8.9 0.7 16.1 15 2 0 15 15 15 0 Domain of unknown function (DUF5122) beta-propeller HlyD_3 PF13437.6 CDK99847.1 - 2.3e-18 66.8 0.3 3.3e-12 47.0 0.0 2.2 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CDK99847.1 - 2.6e-09 36.6 0.1 4.1e-09 36.0 0.1 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDK99847.1 - 4.6e-09 36.0 0.0 1.3e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK99847.1 - 0.00084 19.1 0.2 0.0036 17.1 0.0 2.0 2 0 0 2 2 2 1 Biotin-requiring enzyme DUF1156 PF06634.12 CDK99847.1 - 0.083 13.0 0.4 0.21 11.7 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1156) HlyD_3 PF13437.6 CDK99848.1 - 8.1e-05 23.3 0.0 0.0018 18.9 0.0 2.4 2 1 0 2 2 2 1 HlyD family secretion protein Peptidase_M50 PF02163.22 CDK99848.1 - 0.00048 19.5 3.5 0.0078 15.5 0.5 2.9 1 1 0 2 2 2 1 Peptidase family M50 HlyD_D23 PF16576.5 CDK99848.1 - 0.011 15.0 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion KOW PF00467.29 CDK99848.1 - 0.19 11.7 0.0 0.39 10.7 0.0 1.6 1 0 0 1 1 1 0 KOW motif ATP-synt_DE PF00401.20 CDK99849.1 - 0.9 9.9 8.0 0.87 9.9 6.6 1.8 1 1 1 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain TraW_N PF12477.8 CDK99849.1 - 2.3 8.3 6.9 4.3 7.4 6.9 1.4 1 0 0 1 1 1 0 Sex factor F TraW protein N terminal Hemerythrin PF01814.23 CDK99850.1 - 2.5e-08 34.6 4.1 3.2e-08 34.3 4.1 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Utp13 PF08625.11 CDK99850.1 - 0.0046 16.9 0.2 0.0089 15.9 0.1 1.6 1 1 0 1 1 1 1 Utp13 specific WD40 associated domain SseB_C PF14581.6 CDK99850.1 - 0.034 14.2 0.5 0.061 13.4 0.2 1.5 2 0 0 2 2 2 0 SseB protein C-terminal domain NinB PF05772.12 CDK99850.1 - 0.22 11.4 1.6 6.7 6.5 0.1 2.9 2 1 1 3 3 3 0 NinB protein GGDEF PF00990.21 CDK99852.1 - 3.3e-43 147.2 0.0 4.8e-40 136.9 0.0 2.2 2 0 0 2 2 2 2 Diguanylate cyclase, GGDEF domain PAS_7 PF12860.7 CDK99852.1 - 3.3e-31 107.8 0.0 1.4e-30 105.8 0.0 2.1 2 0 0 2 2 2 1 PAS fold Hemerythrin PF01814.23 CDK99852.1 - 1.6e-08 35.2 0.8 1.6e-08 35.2 0.8 2.3 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain PAS_4 PF08448.10 CDK99852.1 - 0.057 13.7 0.1 0.53 10.6 0.1 2.5 1 1 0 1 1 1 0 PAS fold ATP-cone PF03477.16 CDK99854.1 - 6.7e-18 65.1 0.1 8.6e-18 64.7 0.1 1.1 1 0 0 1 1 1 1 ATP cone domain TF_Zn_Ribbon PF08271.12 CDK99854.1 - 0.003 17.0 1.2 0.25 10.9 0.3 2.4 2 0 0 2 2 2 1 TFIIB zinc-binding Lar_restr_allev PF14354.6 CDK99854.1 - 0.016 15.5 1.1 0.053 13.9 1.1 1.8 1 1 0 1 1 1 0 Restriction alleviation protein Lar TFIIS_C PF01096.18 CDK99854.1 - 0.026 14.4 1.7 0.4 10.6 0.1 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-ISL3 PF14690.6 CDK99854.1 - 0.028 15.1 1.8 9 7.1 0.2 2.6 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-ribbon_3 PF13248.6 CDK99854.1 - 0.05 13.0 0.6 2.8 7.5 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain PBC PF03792.13 CDK99854.1 - 0.07 12.9 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 PBC domain UXS1_N PF11803.8 CDK99854.1 - 0.12 12.8 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 UDP-glucuronate decarboxylase N-terminal zf-Di19 PF05605.12 CDK99854.1 - 0.22 11.8 2.4 0.95 9.8 2.4 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Nudix_N_2 PF14803.6 CDK99854.1 - 0.42 10.6 3.9 1.2 9.2 3.9 1.7 1 0 0 1 1 1 0 Nudix N-terminal UPF0547 PF10571.9 CDK99854.1 - 0.59 10.3 4.0 0.71 10.0 0.2 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Zn_Tnp_IS1595 PF12760.7 CDK99854.1 - 0.63 10.1 5.9 7.8 6.6 0.7 2.2 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_9 PF14369.6 CDK99854.1 - 1.1 9.6 3.3 2.1 8.7 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon Zn-ribbon_8 PF09723.10 CDK99854.1 - 2.1 8.5 4.5 8.8 6.5 4.4 2.1 1 1 0 1 1 1 0 Zinc ribbon domain SoPB_HTH PF18090.1 CDK99856.1 - 0.099 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Centromere-binding protein HTH domain DDE_Tnp_IS66 PF03050.14 CDK99859.1 - 2.1e-76 257.1 0.0 3.4e-76 256.4 0.0 1.3 1 0 0 1 1 1 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK99859.1 - 2.7e-18 65.9 0.0 5.7e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 IS66 C-terminal element PAS_9 PF13426.7 CDK99860.1 - 4.7e-10 39.7 0.0 6.5e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 CDK99860.1 - 1.9e-08 34.5 0.0 2.6e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CDK99860.1 - 3.8e-08 33.3 0.0 5.6e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDK99860.1 - 6.6e-05 23.1 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK99860.1 - 0.0065 16.5 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 PAS domain Vg_Tdu PF07545.14 CDK99861.1 - 0.0089 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Vestigial/Tondu family Protamine_like PF06382.11 CDK99861.1 - 0.13 12.4 0.0 20 5.3 0.0 2.3 2 0 0 2 2 2 0 Protamine and protamine like Response_reg PF00072.24 CDK99861.1 - 0.18 11.9 0.0 0.57 10.4 0.0 1.9 1 1 0 1 1 1 0 Response regulator receiver domain DDE_Tnp_1_4 PF13701.6 CDK99863.1 - 3.1e-42 144.3 0.1 3.8e-42 144.1 0.1 1.0 1 0 0 1 1 1 1 Transposase DDE domain group 1 DDE_Tnp_1 PF01609.21 CDK99863.1 - 7.2e-11 42.1 0.3 1.3e-10 41.3 0.3 1.4 1 1 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_4 PF13701.6 CDK99864.1 - 4.7e-51 173.4 0.0 5.5e-51 173.2 0.0 1.0 1 0 0 1 1 1 1 Transposase DDE domain group 1 DDE_Tnp_1 PF01609.21 CDK99866.1 - 9.3e-11 41.8 0.0 1.1e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 Transposase DDE domain rve PF00665.26 CDK99867.1 - 5.3e-26 91.2 0.0 7.4e-26 90.7 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain HTH_21 PF13276.6 CDK99867.1 - 1.4e-07 31.5 1.2 2.5e-07 30.7 1.2 1.4 1 0 0 1 1 1 1 HTH-like domain DDE_Tnp_IS240 PF13610.6 CDK99867.1 - 0.0025 18.1 0.1 0.0063 16.8 0.1 1.7 1 1 0 1 1 1 1 DDE domain rve_3 PF13683.6 CDK99867.1 - 0.019 14.7 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_1 PF01527.20 CDK99868.1 - 3e-16 59.5 0.3 4.5e-16 58.9 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDK99868.1 - 3.9e-06 26.5 0.0 6.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 CDK99868.1 - 0.0076 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 CDK99868.1 - 0.02 15.0 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 CDK99868.1 - 0.045 13.4 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.6 CDK99868.1 - 0.076 13.0 0.2 0.68 10.0 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn helix HTH_35 PF13693.6 CDK99868.1 - 0.13 12.3 0.0 1 9.4 0.0 2.0 1 1 1 2 2 2 0 Winged helix-turn-helix DNA-binding TnpB_IS66 PF05717.13 CDK99869.1 - 9.3e-38 128.2 0.0 1e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein DDE_Tnp_IS66 PF03050.14 CDK99870.1 - 2.9e-89 299.3 0.4 4.9e-89 298.6 0.0 1.6 2 0 0 2 2 2 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDK99870.1 - 2.9e-18 65.8 0.0 1e-17 64.0 0.0 2.0 1 0 0 1 1 1 1 IS66 C-terminal element LZ_Tnp_IS66 PF13007.7 CDK99870.1 - 3e-16 59.9 4.3 3e-16 59.9 4.3 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDK99870.1 - 1.5e-15 57.3 4.6 2.9e-15 56.4 4.6 1.5 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDK99870.1 - 0.18 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.12 CDK99870.1 - 1.1 10.0 3.9 11 6.8 2.2 2.9 2 1 1 3 3 3 0 SlyX MqsA_antitoxin PF15731.5 CDK99873.1 - 5.9e-06 26.4 0.2 6.4e-06 26.3 0.2 1.1 1 0 0 1 1 1 1 Antitoxin component of bacterial toxin-antitoxin system, MqsA OrfB_Zn_ribbon PF07282.11 CDK99873.1 - 0.014 15.3 0.3 0.19 11.7 0.1 2.1 2 0 0 2 2 2 0 Putative transposase DNA-binding domain HTH_20 PF12840.7 CDK99874.1 - 3.3e-05 23.9 1.4 5.9e-05 23.1 1.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 CDK99874.1 - 0.00014 21.6 0.4 0.00028 20.7 0.4 1.5 1 0 0 1 1 1 1 MarR family MarR PF01047.22 CDK99874.1 - 0.0002 21.2 0.0 0.00033 20.5 0.0 1.4 1 0 0 1 1 1 1 MarR family DUF4423 PF14394.6 CDK99874.1 - 0.018 14.8 0.1 0.029 14.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) TrmB PF01978.19 CDK99874.1 - 0.023 14.6 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF1917 PF08939.10 CDK99874.1 - 0.026 14.4 0.2 0.031 14.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) DUF2250 PF10007.9 CDK99874.1 - 0.041 14.0 0.1 0.064 13.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) HTH_AsnC-type PF13404.6 CDK99874.1 - 0.048 13.5 0.1 0.097 12.5 0.1 1.5 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_27 PF13463.6 CDK99874.1 - 0.05 14.1 0.3 0.071 13.6 0.3 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain B-block_TFIIIC PF04182.12 CDK99874.1 - 0.089 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC DUF5131 PF07505.11 CDK99876.1 - 1.8e-97 325.7 0.0 2e-97 325.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF5131) Ribosomal_S20p PF01649.18 CDK99879.1 - 0.0043 17.7 0.7 0.13 12.9 0.1 2.0 1 1 1 2 2 2 1 Ribosomal protein S20 DUF1525 PF07511.11 CDK99879.1 - 0.036 14.2 3.7 0.043 13.9 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) Cas_Cas1 PF01867.16 CDK99879.1 - 0.038 13.1 0.9 0.039 13.1 0.9 1.1 1 0 0 1 1 1 0 CRISPR associated protein Cas1 Vps5 PF09325.10 CDK99879.1 - 0.048 13.2 0.1 0.05 13.2 0.1 1.1 1 0 0 1 1 1 0 Vps5 C terminal like KELK PF15796.5 CDK99879.1 - 0.05 14.1 0.3 0.07 13.6 0.3 1.3 1 1 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase tRNA_synt_2f PF02092.17 CDK99881.1 - 0.22 10.4 0.0 0.31 9.9 0.0 1.2 1 0 0 1 1 1 0 Glycyl-tRNA synthetase beta subunit PilZ PF07238.14 CDK99882.1 - 0.016 15.5 0.0 0.023 15.0 0.0 1.3 1 0 0 1 1 1 0 PilZ domain MlaC PF05494.12 CDK99883.1 - 2.8e-36 124.8 0.0 3.4e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 MlaC protein MlaA PF04333.13 CDK99884.1 - 1.1e-69 234.0 0.0 1.3e-69 233.8 0.0 1.0 1 0 0 1 1 1 1 MlaA lipoprotein Methyltransf_11 PF08241.12 CDK99885.1 - 4.8e-24 84.8 0.1 1.1e-23 83.7 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDK99885.1 - 8e-21 74.4 0.0 1.1e-19 70.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK99885.1 - 4.2e-20 72.2 0.5 2.5e-19 69.8 0.1 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDK99885.1 - 2e-15 57.0 0.0 3.3e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK99885.1 - 9.2e-15 55.2 0.1 4.3e-14 53.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain HTH_5 PF01022.20 CDK99885.1 - 4.4e-12 45.7 1.0 9.4e-12 44.6 1.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family Ubie_methyltran PF01209.18 CDK99885.1 - 8.7e-11 41.6 0.0 1.3e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family HTH_20 PF12840.7 CDK99885.1 - 1.5e-08 34.5 1.5 1.5e-08 34.5 1.5 2.4 3 0 0 3 3 3 1 Helix-turn-helix domain MarR_2 PF12802.7 CDK99885.1 - 3.1e-08 33.4 1.1 1.8e-07 30.9 0.4 2.7 2 0 0 2 2 1 1 MarR family MTS PF05175.14 CDK99885.1 - 7.7e-07 28.8 0.1 1.4e-06 28.0 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain NodS PF05401.11 CDK99885.1 - 6.8e-06 25.8 0.1 1e-05 25.2 0.1 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_2 PF00891.18 CDK99885.1 - 1.2e-05 24.7 0.2 1.7e-05 24.2 0.2 1.1 1 0 0 1 1 1 1 O-methyltransferase domain HTH_24 PF13412.6 CDK99885.1 - 2.1e-05 24.0 0.1 5.5e-05 22.6 0.1 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Methyltransf_8 PF05148.15 CDK99885.1 - 6.4e-05 22.9 0.0 0.0001 22.3 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase PCMT PF01135.19 CDK99885.1 - 0.0012 18.6 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MarR PF01047.22 CDK99885.1 - 0.002 18.0 0.0 0.0039 17.1 0.0 1.4 1 0 0 1 1 1 1 MarR family MetW PF07021.12 CDK99885.1 - 0.004 16.8 0.0 0.0065 16.1 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TrmB PF01978.19 CDK99885.1 - 0.0063 16.4 0.0 0.017 15.0 0.0 1.7 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB CMAS PF02353.20 CDK99885.1 - 0.019 14.3 0.0 0.026 13.8 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase UPF0020 PF01170.18 CDK99885.1 - 0.027 14.2 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 HTH_37 PF13744.6 CDK99885.1 - 0.03 14.3 0.2 0.8 9.7 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_IclR PF09339.10 CDK99885.1 - 0.035 13.9 3.4 0.11 12.3 2.7 2.4 2 1 0 2 2 2 0 IclR helix-turn-helix domain DREV PF05219.12 CDK99885.1 - 0.057 12.5 0.0 0.088 11.9 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase AbiEi_4 PF13338.6 CDK99885.1 - 0.063 13.4 1.9 0.73 10.0 0.1 3.4 3 0 0 3 3 3 0 Transcriptional regulator, AbiEi antitoxin MTHFR PF02219.17 CDK99886.1 - 4e-97 325.0 0.0 4.9e-97 324.7 0.0 1.0 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase SLATT_2 PF18183.1 CDK99886.1 - 0.073 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 2 S-methyl_trans PF02574.16 CDK99887.1 - 4e-56 190.8 0.0 8.9e-56 189.6 0.0 1.6 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Met_synt_B12 PF02965.17 CDK99887.1 - 8.5e-47 159.9 0.0 1.2e-46 159.4 0.0 1.2 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain Pterin_bind PF00809.22 CDK99887.1 - 5.2e-42 144.2 0.0 1.2e-41 143.0 0.0 1.6 1 0 0 1 1 1 1 Pterin binding enzyme B12-binding_2 PF02607.17 CDK99887.1 - 2e-26 92.2 0.4 6.3e-26 90.6 0.3 2.0 2 0 0 2 2 2 1 B12 binding domain B12-binding PF02310.19 CDK99887.1 - 2.3e-20 72.8 1.0 1.4e-19 70.3 0.3 2.7 2 0 0 2 2 2 1 B12 binding domain CdhD PF03599.16 CDK99887.1 - 0.00067 18.5 0.0 0.0013 17.5 0.0 1.4 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit ImpA_N PF06812.12 CDK99887.1 - 0.063 13.4 0.2 2.4 8.3 0.0 2.7 3 0 0 3 3 3 0 ImpA, N-terminal, type VI secretion system RibD_C PF01872.17 CDK99887.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 RibD C-terminal domain MM_CoA_mutase PF01642.22 CDK99888.1 - 4.7e-128 427.9 0.0 6.1e-128 427.6 0.0 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 CDK99888.1 - 2e-16 60.1 0.4 4.2e-16 59.1 0.4 1.5 1 0 0 1 1 1 1 B12 binding domain ADH_zinc_N PF00107.26 CDK99889.1 - 3.1e-32 111.3 0.2 5.2e-32 110.5 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDK99889.1 - 9.3e-16 57.7 0.1 2.8e-15 56.2 0.1 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CDK99889.1 - 6e-05 24.1 0.0 0.00011 23.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Acyl-CoA_dh_1 PF00441.24 CDK99890.1 - 1.4e-39 135.7 8.1 1.2e-38 132.7 4.6 2.4 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CDK99890.1 - 9.8e-31 106.7 0.1 9.8e-31 106.7 0.1 2.2 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CDK99890.1 - 1.4e-16 60.5 0.0 2.6e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CDK99890.1 - 5.8e-11 42.8 1.1 5.8e-11 42.8 1.1 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Trypan_glycop PF00913.19 CDK99890.1 - 0.075 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Lectin_C PF00059.21 CDK99891.1 - 0.0028 18.3 5.3 0.018 15.8 5.3 2.0 1 1 0 1 1 1 1 Lectin C-type domain MCPsignal PF00015.21 CDK99892.1 - 3.6e-30 105.0 24.0 3.6e-30 105.0 24.0 5.8 2 2 3 5 5 5 2 Methyl-accepting chemotaxis protein (MCP) signalling domain 4HB_MCP_1 PF12729.7 CDK99892.1 - 5.5e-10 39.1 3.2 5.5e-10 39.1 3.2 3.3 2 1 1 3 3 3 1 Four helix bundle sensory module for signal transduction HAMP PF00672.25 CDK99892.1 - 4.5e-07 30.2 5.4 8.1e-07 29.3 0.2 3.8 2 1 0 2 2 2 1 HAMP domain DUF948 PF06103.11 CDK99892.1 - 0.00027 21.1 14.9 0.0027 17.9 3.9 6.7 2 2 2 6 6 6 3 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 CDK99892.1 - 0.11 12.5 21.0 0.059 13.4 4.2 5.4 3 3 3 6 6 6 0 Protein of unknown function (DUF1664) Sec34 PF04136.15 CDK99892.1 - 0.14 12.1 5.3 0.4 10.6 0.2 3.4 2 1 1 3 3 3 0 Sec34-like family WXG100 PF06013.12 CDK99892.1 - 0.18 12.1 29.3 1.9 8.8 1.4 5.9 5 2 0 5 5 5 0 Proteins of 100 residues with WXG CorA PF01544.18 CDK99892.1 - 0.93 8.7 13.2 1.7 7.9 2.0 2.8 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein FlaC_arch PF05377.11 CDK99892.1 - 1.9 9.0 8.9 5.3 7.5 0.2 5.0 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) DUF4995 PF16386.5 CDK99892.1 - 3.2 7.8 7.0 2.7 8.1 0.1 3.7 4 0 0 4 4 4 0 Domain of unknown function Goodbye PF17109.5 CDK99892.1 - 6.9 7.1 14.1 1.9 9.0 1.7 4.5 3 2 1 5 5 5 0 fungal STAND N-terminal Goodbye domain TMPIT PF07851.13 CDK99892.1 - 9.6 5.3 10.2 0.78 8.9 1.2 3.1 3 1 0 3 3 3 0 TMPIT-like protein ArsC PF03960.15 CDK99893.1 - 2.3e-12 46.8 0.0 3e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 ArsC family Glutaredoxin PF00462.24 CDK99893.1 - 0.012 15.8 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin MS_channel PF00924.18 CDK99894.1 - 2.6e-41 141.4 0.8 2.6e-41 141.4 0.8 1.4 2 0 0 2 2 2 1 Mechanosensitive ion channel DUF2171 PF09939.9 CDK99894.1 - 0.0017 18.6 0.0 0.0032 17.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2171) Na_Ala_symp PF01235.17 CDK99894.1 - 0.0069 15.7 0.2 0.013 14.8 0.2 1.5 1 1 0 1 1 1 1 Sodium:alanine symporter family ATP-synt_I PF03899.15 CDK99894.1 - 0.87 10.0 11.8 0.42 11.0 6.5 2.8 2 1 0 2 2 2 0 ATP synthase I chain RecX PF02631.16 CDK99895.1 - 6.7e-24 84.7 0.5 1.1e-23 84.0 0.5 1.3 1 0 0 1 1 1 1 RecX family ABC2_membrane PF01061.24 CDK99896.1 - 8.3e-32 110.3 18.2 1.1e-31 109.9 18.2 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CDK99896.1 - 1.2e-08 34.4 15.1 1.2e-08 34.4 15.1 1.6 2 0 0 2 2 2 1 ABC-2 family transporter protein DUF3938 PF13074.6 CDK99896.1 - 1.5 9.1 5.0 2.9 8.2 1.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3938) Oxidored_q6 PF01058.22 CDK99897.1 - 2.5e-28 98.5 0.5 3.2e-28 98.2 0.5 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Complex1_49kDa PF00346.19 CDK99898.1 - 2.5e-39 135.0 0.0 1.9e-31 109.2 0.0 2.1 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 CDK99898.1 - 5.8e-08 32.1 0.0 4.3e-07 29.2 0.0 2.1 3 0 0 3 3 3 1 Nickel-dependent hydrogenase Complex1_30kDa PF00329.19 CDK99898.1 - 0.00038 21.1 0.1 0.00072 20.2 0.1 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit Proton_antipo_M PF00361.20 CDK99899.1 - 1.6e-52 178.6 20.1 1.6e-52 178.6 20.1 1.7 2 0 0 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 CDK99899.1 - 0.0017 18.3 1.1 0.0093 16.0 1.1 2.3 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus NADHdh PF00146.21 CDK99901.1 - 8.7e-37 127.0 20.8 1.1e-36 126.7 20.8 1.0 1 0 0 1 1 1 1 NADH dehydrogenase Proton_antipo_M PF00361.20 CDK99902.1 - 8.8e-50 169.5 19.3 8.8e-50 169.5 19.3 2.6 2 1 0 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 CDK99902.1 - 0.015 15.3 0.0 0.015 15.3 0.0 3.4 4 0 0 4 4 4 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Toprim_4 PF13662.6 CDK99903.1 - 1.8e-20 73.2 0.0 2.6e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Toprim domain RecR PF02132.15 CDK99903.1 - 8.7e-16 57.2 0.3 1.6e-15 56.4 0.3 1.4 1 0 0 1 1 1 1 RecR protein Toprim PF01751.22 CDK99903.1 - 0.094 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Toprim domain HHH_5 PF14520.6 CDK99903.1 - 0.11 13.1 0.2 1.3 9.6 0.0 2.5 3 0 0 3 3 3 0 Helix-hairpin-helix domain HHH PF00633.23 CDK99903.1 - 0.14 12.1 1.1 5.7 7.0 0.0 3.1 3 0 0 3 3 3 0 Helix-hairpin-helix motif YbaB_DNA_bd PF02575.16 CDK99904.1 - 1e-33 115.4 11.0 1.2e-33 115.2 11.0 1.0 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family DNA_pol3_gamma3 PF12169.8 CDK99905.1 - 1.1e-53 180.9 4.7 2.6e-53 179.8 4.7 1.7 1 0 0 1 1 1 1 DNA polymerase III subunits gamma and tau domain III DUF3646 PF12362.8 CDK99905.1 - 4.2e-39 133.4 0.3 8e-39 132.5 0.3 1.5 1 0 0 1 1 1 1 DNA polymerase III gamma and tau subunits C terminal DNA_pol3_delta2 PF13177.6 CDK99905.1 - 4.8e-39 133.8 0.0 6.5e-39 133.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 CDK99905.1 - 1.3e-11 45.0 1.1 1.2e-10 41.9 1.1 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDK99905.1 - 5.2e-06 26.8 0.0 0.00028 21.2 0.0 2.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDK99905.1 - 9.6e-06 25.4 0.1 3.3e-05 23.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CDK99905.1 - 3.2e-05 23.7 0.2 0.00081 19.2 0.0 2.3 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDK99905.1 - 4.8e-05 23.4 0.2 0.41 10.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDK99905.1 - 9.4e-05 22.9 1.9 0.0007 20.0 0.2 2.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 CDK99905.1 - 0.00015 21.8 0.0 0.00078 19.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDK99905.1 - 0.0007 20.2 0.0 0.0027 18.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CDK99905.1 - 0.0025 17.6 0.0 0.0054 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 CDK99905.1 - 0.0065 15.7 0.0 0.039 13.1 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_19 PF13245.6 CDK99905.1 - 0.0097 16.2 0.8 0.29 11.5 0.8 2.5 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 CDK99905.1 - 0.012 14.9 0.2 1.7 7.8 0.0 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain ResIII PF04851.15 CDK99905.1 - 0.041 13.9 0.7 0.66 10.0 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 CDK99905.1 - 0.058 12.8 0.1 0.13 11.6 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_assoc_2 PF16193.5 CDK99905.1 - 0.081 13.3 0.1 0.18 12.1 0.1 1.6 1 0 0 1 1 1 0 AAA C-terminal domain TsaE PF02367.17 CDK99905.1 - 0.12 12.4 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 CDK99905.1 - 0.2 11.5 0.7 0.63 9.9 0.2 1.9 2 0 0 2 2 2 0 NTPase NMT1_3 PF16868.5 CDK99906.1 - 1.3e-69 234.8 0.0 1.7e-69 234.5 0.0 1.1 1 0 0 1 1 1 1 NMT1-like family Phosphonate-bd PF12974.7 CDK99906.1 - 4.3e-07 29.8 0.4 1.2e-06 28.3 0.3 1.7 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1 PF09084.11 CDK99906.1 - 6.1e-06 26.3 0.0 1.3e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 CDK99906.1 - 0.00062 19.5 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 NMT1-like family Cytochrom_C PF00034.21 CDK99908.1 - 1.5e-05 26.1 0.0 2e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CDK99908.1 - 0.002 18.4 0.0 0.0026 18.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cpn10 PF00166.21 CDK99909.1 - 3.3e-36 123.2 0.1 3.6e-36 123.1 0.1 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Cpn60_TCP1 PF00118.24 CDK99910.1 - 1.7e-102 343.6 16.0 2.7e-102 342.9 16.0 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pol_alpha_B_N PF08418.10 CDK99911.1 - 0.083 12.8 1.9 0.092 12.7 1.9 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Mu-like_Pro PF10123.9 CDK99911.1 - 0.086 12.4 4.1 0.097 12.2 4.1 1.0 1 0 0 1 1 1 0 Mu-like prophage I protein PriA_C PF18074.1 CDK99911.1 - 0.17 12.7 1.7 0.29 12.0 1.7 1.5 1 1 0 1 1 1 0 Primosomal protein N C-terminal domain TipAS PF07739.13 CDK99911.1 - 0.21 12.1 3.0 0.99 10.0 2.8 1.9 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain MeaB PF03308.16 CDK99912.1 - 9.8e-107 355.9 1.4 1.1e-106 355.7 1.4 1.0 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 CDK99912.1 - 2.3e-06 27.3 0.3 1.8e-05 24.4 0.3 2.4 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 CDK99912.1 - 0.00027 20.7 0.0 0.00043 20.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 CDK99912.1 - 0.001 18.9 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 CDK99912.1 - 0.0041 16.8 0.2 0.034 13.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF463 PF04317.12 CDK99912.1 - 0.012 14.6 0.0 0.022 13.7 0.0 1.4 1 0 0 1 1 1 0 YcjX-like family, DUF463 IstB_IS21 PF01695.17 CDK99912.1 - 0.015 15.0 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 CDK99912.1 - 0.017 15.5 0.4 0.84 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 CDK99912.1 - 0.026 15.0 0.1 0.059 13.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain PALP PF00291.25 CDK99912.1 - 0.031 13.7 0.6 0.45 9.9 0.2 2.3 1 1 1 2 2 2 0 Pyridoxal-phosphate dependent enzyme MMR_HSR1 PF01926.23 CDK99912.1 - 0.042 13.9 0.0 0.21 11.7 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 CDK99912.1 - 0.05 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase PF06745.13 CDK99912.1 - 0.059 12.7 0.0 0.089 12.1 0.0 1.3 1 0 0 1 1 1 0 KaiC ABC_tran PF00005.27 CDK99912.1 - 0.073 13.6 0.1 0.21 12.1 0.0 1.7 2 0 0 2 2 2 0 ABC transporter SRP54 PF00448.22 CDK99912.1 - 0.086 12.5 0.0 1.4 8.5 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ArsA_ATPase PF02374.15 CDK99912.1 - 0.087 12.0 0.1 0.2 10.8 0.1 1.6 2 0 0 2 2 2 0 Anion-transporting ATPase NTPase_1 PF03266.15 CDK99912.1 - 0.095 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 NTPase Viral_helicase1 PF01443.18 CDK99912.1 - 0.099 12.4 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CDK99912.1 - 0.15 12.4 0.0 0.42 10.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain CheZ PF04344.13 CDK99913.1 - 3.8e-12 46.6 2.8 1.1e-09 38.5 0.7 2.1 1 1 1 2 2 2 2 Chemotaxis phosphatase, CheZ CitT PF12431.8 CDK99913.1 - 0.031 14.7 3.2 1.2 9.6 0.5 3.0 2 1 1 3 3 3 0 Transcriptional regulator Ribosomal_L28 PF00830.19 CDK99914.1 - 3.1e-25 88.1 0.6 4.3e-25 87.7 0.6 1.2 1 0 0 1 1 1 1 Ribosomal L28 family Cytochrom_C PF00034.21 CDK99915.1 - 9.8e-17 61.9 0.3 9.5e-07 29.9 0.0 2.8 2 2 0 2 2 2 2 Cytochrome c Cytochrome_CBB3 PF13442.6 CDK99915.1 - 1.3e-13 51.0 0.2 7.2e-06 26.2 0.0 2.4 2 0 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 CDK99915.1 - 0.0083 15.8 0.1 0.048 13.4 0.0 2.2 3 0 0 3 3 3 1 Cytochrome c-550 domain Cytochrome_C7 PF14522.6 CDK99915.1 - 0.038 14.0 0.0 13 5.9 0.0 2.3 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c MoCF_biosynth PF00994.24 CDK99916.1 - 3.4e-31 107.8 0.0 4e-31 107.6 0.0 1.0 1 0 0 1 1 1 1 Probable molybdopterin binding domain GTP_EFTU PF00009.27 CDK99917.1 - 1.7e-53 181.1 0.2 2.6e-53 180.5 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 CDK99917.1 - 2.3e-50 169.3 0.3 4.3e-50 168.3 0.3 1.5 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CDK99917.1 - 2e-21 75.8 0.0 4.3e-21 74.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDK99917.1 - 1.5e-08 34.9 0.6 3.3e-08 33.8 0.6 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDK99917.1 - 7.3e-06 26.1 0.0 1.6e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CDK99917.1 - 3e-05 24.0 0.0 0.00013 22.0 0.0 2.0 1 1 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.22 CDK99917.1 - 0.0011 18.6 0.0 0.0021 17.7 0.0 1.3 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 CDK99917.1 - 0.0049 16.3 0.0 0.013 15.0 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 CDK99917.1 - 0.013 15.5 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 CDK99917.1 - 0.02 14.4 0.2 0.086 12.4 0.2 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B Roc PF08477.13 CDK99917.1 - 0.026 14.7 0.0 0.071 13.3 0.0 1.7 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RF3_C PF16658.5 CDK99917.1 - 0.078 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain ADH_zinc_N_2 PF13602.6 CDK99918.1 - 3.1e-16 60.6 0.3 6e-16 59.7 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CDK99918.1 - 5.2e-12 45.9 0.2 1.2e-11 44.7 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDK99918.1 - 4e-06 26.7 0.0 6.8e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain HxlR PF01638.17 CDK99919.1 - 1.6e-35 120.8 0.0 1.9e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_20 PF12840.7 CDK99919.1 - 0.0015 18.5 0.5 0.0029 17.6 0.4 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 CDK99919.1 - 0.0044 16.9 0.1 0.0072 16.2 0.1 1.3 1 0 0 1 1 1 1 MarR family PadR PF03551.14 CDK99919.1 - 0.038 14.0 0.0 0.061 13.3 0.0 1.4 1 1 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_12 PF08461.10 CDK99919.1 - 0.09 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain HTH_34 PF13601.6 CDK99919.1 - 0.095 12.9 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_45 PF14947.6 CDK99919.1 - 0.13 12.3 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DUF1476 PF07345.11 CDK99920.1 - 2.5e-15 56.7 0.1 2.8e-15 56.5 0.1 1.0 1 0 0 1 1 1 1 ATPase inhibitor subunit zeta HTH_5 PF01022.20 CDK99921.1 - 9.5e-11 41.4 2.0 1.6e-10 40.7 0.5 2.2 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 CDK99921.1 - 4.3e-08 33.1 6.5 1.8e-07 31.1 2.8 2.9 3 0 0 3 3 3 1 Helix-turn-helix domain MarR_2 PF12802.7 CDK99921.1 - 2.3e-07 30.6 2.6 2.3e-07 30.6 2.6 3.1 1 1 2 3 3 3 1 MarR family Rrf2 PF02082.20 CDK99921.1 - 0.0015 18.9 0.2 0.02 15.3 0.1 2.7 2 1 1 3 3 3 1 Transcriptional regulator HxlR PF01638.17 CDK99921.1 - 0.0038 17.1 0.0 0.0088 15.9 0.0 1.6 2 0 0 2 2 2 1 HxlR-like helix-turn-helix LexA_DNA_bind PF01726.16 CDK99921.1 - 0.004 16.9 0.2 0.014 15.2 0.2 1.9 1 0 0 1 1 1 1 LexA DNA binding domain HTH_28 PF13518.6 CDK99921.1 - 0.0043 17.1 0.5 0.012 15.7 0.5 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 CDK99921.1 - 0.018 14.9 0.4 0.087 12.7 0.1 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DprA_WH PF17782.1 CDK99921.1 - 0.05 13.7 1.0 0.05 13.7 1.0 2.1 2 1 0 2 2 2 0 DprA winged helix domain GHMP_kinases_C PF08544.13 CDK99921.1 - 0.092 13.1 1.5 0.33 11.4 0.4 2.4 1 1 2 3 3 3 0 GHMP kinases C terminal HTH_34 PF13601.6 CDK99921.1 - 0.11 12.7 0.0 0.97 9.7 0.0 2.0 2 0 0 2 2 2 0 Winged helix DNA-binding domain TFIIE_alpha PF02002.17 CDK99921.1 - 0.12 12.2 0.0 11 6.0 0.0 2.2 2 0 0 2 2 2 0 TFIIE alpha subunit MarR PF01047.22 CDK99921.1 - 0.13 12.2 0.1 0.5 10.3 0.1 2.0 2 0 0 2 2 2 0 MarR family HTH_Crp_2 PF13545.6 CDK99921.1 - 0.59 10.1 3.2 2.7 8.1 1.2 3.0 3 2 1 4 4 4 0 Crp-like helix-turn-helix domain Response_reg PF00072.24 CDK99922.1 - 1.1e-24 86.8 2.3 1.6e-24 86.2 2.3 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Hydrolase PF00702.26 CDK99922.1 - 0.0098 16.2 0.0 0.013 15.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase RE_TdeIII PF09520.10 CDK99922.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II restriction endonuclease, TdeIII GGDEF PF00990.21 CDK99923.1 - 5.5e-50 169.3 0.0 8.5e-50 168.6 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain sCache_2 PF17200.4 CDK99923.1 - 2.9e-34 118.2 0.0 1.1e-33 116.3 0.0 1.9 2 0 0 2 2 2 1 Single Cache domain 2 dCache_2 PF08269.11 CDK99923.1 - 6.7e-27 94.4 0.0 1.1e-26 93.7 0.0 1.2 1 0 0 1 1 1 1 Cache domain PAS_9 PF13426.7 CDK99923.1 - 2.5e-16 59.8 0.0 4.9e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CDK99923.1 - 2e-12 47.1 0.0 4.4e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDK99923.1 - 2.1e-11 43.5 0.0 6.5e-11 42.0 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDK99923.1 - 4.2e-11 43.1 0.1 3e-10 40.3 0.0 2.4 2 0 0 2 2 2 1 PAS fold Cache_3-Cache_2 PF17201.4 CDK99923.1 - 3.9e-09 36.2 0.0 6.6e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain HAMP PF00672.25 CDK99923.1 - 4.5e-08 33.3 0.2 4.5e-08 33.3 0.2 2.3 3 0 0 3 3 3 1 HAMP domain PAS_3 PF08447.12 CDK99923.1 - 1.9e-06 28.1 0.5 7e-06 26.2 0.0 2.3 3 0 0 3 3 3 1 PAS fold PAS_7 PF12860.7 CDK99923.1 - 9.8e-05 22.5 1.0 0.0012 19.0 0.1 2.8 2 1 0 2 2 2 1 PAS fold PAS_12 PF18095.1 CDK99923.1 - 0.025 14.2 0.0 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 UPF0242 C-terminal PAS-like domain TarH PF02203.15 CDK99923.1 - 0.034 14.1 0.7 0.081 12.8 0.7 1.6 1 0 0 1 1 1 0 Tar ligand binding domain homologue sCache_2 PF17200.4 CDK99925.1 - 7.2e-31 107.1 0.0 1.5e-30 106.1 0.0 1.5 1 0 0 1 1 1 1 Single Cache domain 2 GGDEF PF00990.21 CDK99925.1 - 9.2e-31 106.8 0.0 1.6e-30 106.0 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain dCache_2 PF08269.11 CDK99925.1 - 2.2e-23 82.9 0.0 3.5e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 Cache domain PAS PF00989.25 CDK99925.1 - 1.7e-14 53.8 0.0 4.3e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDK99925.1 - 1.5e-13 50.9 0.0 3.8e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 CDK99925.1 - 2.8e-11 43.6 0.0 6.1e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 PAS fold HAMP PF00672.25 CDK99925.1 - 4.5e-11 43.0 3.5 5.8e-10 39.4 0.3 2.7 2 0 0 2 2 2 1 HAMP domain PAS_4 PF08448.10 CDK99925.1 - 9.7e-09 35.5 1.6 5.5e-08 33.0 0.1 2.9 3 1 0 3 3 3 1 PAS fold Cache_3-Cache_2 PF17201.4 CDK99925.1 - 1.1e-07 31.4 0.0 2.2e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain PAS_8 PF13188.7 CDK99925.1 - 2.6e-06 27.3 0.3 8.5e-05 22.5 0.0 2.7 2 0 0 2 2 2 1 PAS domain MacB_PCD PF12704.7 CDK99925.1 - 0.016 15.6 0.6 0.016 15.6 0.6 2.1 2 2 1 3 3 3 0 MacB-like periplasmic core domain PTS_EIIA_1 PF00358.20 CDK99925.1 - 0.086 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 DUF5061 PF16587.5 CDK99926.1 - 0.0055 16.7 2.5 0.01 15.9 2.5 1.4 1 1 0 1 1 1 1 17 kDa common-antigen outer membrane protein PmbA_TldD PF01523.16 CDK99927.1 - 1.8e-57 195.3 0.1 2.2e-57 195.0 0.1 1.1 1 0 0 1 1 1 1 Putative modulator of DNA gyrase COX15-CtaA PF02628.15 CDK99928.1 - 1.4e-87 293.8 31.6 1.7e-87 293.6 31.6 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF3094 PF11293.8 CDK99928.1 - 0.09 12.5 0.1 0.09 12.5 0.1 3.3 5 0 0 5 5 5 0 Protein of unknown function (DUF3094) Peptidase_M23 PF01551.22 CDK99929.1 - 1e-27 96.2 0.7 1.2e-27 95.9 0.1 1.5 2 0 0 2 2 2 1 Peptidase family M23 Biotin_lipoyl_2 PF13533.6 CDK99929.1 - 0.0073 16.1 0.5 0.059 13.2 0.1 2.6 3 0 0 3 3 3 1 Biotin-lipoyl like Gram_pos_anchor PF00746.21 CDK99930.1 - 0.35 10.8 4.2 0.44 10.5 0.1 2.4 2 0 0 2 2 2 0 LPXTG cell wall anchor motif UPF0114 PF03350.16 CDK99931.1 - 2.3e-33 114.9 5.6 2.3e-33 114.9 5.6 1.5 2 0 0 2 2 2 1 Uncharacterized protein family, UPF0114 Tmemb_161AB PF10268.9 CDK99931.1 - 0.033 12.9 5.8 0.042 12.5 5.8 1.1 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB HemolysinCabind PF00353.19 CDK99932.1 - 3.2e-07 30.2 24.9 1e-06 28.6 14.4 7.2 5 1 2 7 7 7 2 RTX calcium-binding nonapeptide repeat (4 copies) FecR PF04773.13 CDK99932.1 - 3.3e-06 27.7 5.1 3.4e-06 27.6 0.0 3.5 4 0 0 4 4 4 1 FecR protein eIF3_subunit PF08597.10 CDK99932.1 - 0.026 14.5 7.3 0.041 13.8 7.3 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit SWI-SNF_Ssr4 PF08549.10 CDK99932.1 - 0.064 11.9 4.0 0.091 11.4 4.0 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) TFIIA PF03153.13 CDK99932.1 - 0.079 12.9 13.9 0.12 12.3 13.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PRP21_like_P PF12230.8 CDK99932.1 - 0.86 9.4 5.5 1.3 8.8 5.5 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein DUF737 PF05300.11 CDK99932.1 - 1.2 9.5 7.6 1.7 8.9 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) RR_TM4-6 PF06459.12 CDK99932.1 - 1.4 8.7 4.0 2.1 8.1 4.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 OEP PF02321.18 CDK99933.1 - 7.6e-48 162.8 32.0 1.6e-27 96.5 11.8 2.0 2 0 0 2 2 2 2 Outer membrane efflux protein Thioredoxin PF00085.20 CDK99933.1 - 0.034 14.1 0.0 0.21 11.6 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin T3SS_needle_reg PF09025.10 CDK99933.1 - 0.097 12.6 0.0 0.31 11.0 0.0 1.8 1 0 0 1 1 1 0 YopR, type III needle-polymerisation regulator Band_7 PF01145.25 CDK99933.1 - 0.31 11.0 5.5 0.053 13.5 0.8 2.2 2 0 0 2 2 2 0 SPFH domain / Band 7 family ABC_tran PF00005.27 CDK99934.1 - 5.4e-24 85.3 0.0 8.7e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter T2SSE PF00437.20 CDK99934.1 - 4.4e-05 22.7 0.0 7.7e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_membrane PF00664.23 CDK99934.1 - 0.0011 18.7 3.5 0.0021 17.8 3.5 1.4 1 1 0 1 1 1 1 ABC transporter transmembrane region AAA_33 PF13671.6 CDK99934.1 - 0.0025 18.0 0.0 0.026 14.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CDK99934.1 - 0.0089 15.6 2.2 0.013 15.1 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 CDK99934.1 - 0.009 16.3 0.0 0.026 14.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDK99934.1 - 0.02 15.3 0.3 0.02 15.3 0.3 2.9 2 1 1 3 3 3 0 AAA ATPase domain Zeta_toxin PF06414.12 CDK99934.1 - 0.022 14.0 0.2 0.078 12.2 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_18 PF13238.6 CDK99934.1 - 0.026 15.1 0.0 0.061 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CDK99934.1 - 0.038 13.8 0.0 2.2 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDK99934.1 - 0.076 12.8 0.0 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 CDK99934.1 - 0.077 13.0 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 CDK99934.1 - 0.13 12.7 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 CDK99934.1 - 0.16 12.4 0.0 0.26 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDK99934.1 - 0.2 11.4 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDK99934.1 - 0.25 10.7 0.0 0.43 9.9 0.0 1.3 1 0 0 1 1 1 0 KaiC HlyD_3 PF13437.6 CDK99935.1 - 4.2e-20 72.4 0.8 1.6e-16 60.9 0.1 2.6 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CDK99935.1 - 6.2e-10 38.7 5.7 1.7e-07 30.7 0.1 2.4 3 0 0 3 3 3 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD PF00529.20 CDK99935.1 - 1.5e-06 28.0 0.0 2.6e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl_2 PF13533.6 CDK99935.1 - 3.2e-05 23.7 6.5 0.00016 21.4 2.4 3.0 2 1 0 2 2 2 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 CDK99935.1 - 0.0011 18.8 0.5 0.09 12.6 0.0 2.5 2 0 0 2 2 2 1 Biotin-requiring enzyme Nup54 PF13874.6 CDK99935.1 - 0.13 12.4 11.1 0.12 12.5 5.3 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Mt_ATP_synt PF15704.5 CDK99935.1 - 0.13 12.1 1.6 2.2 8.1 0.1 2.1 1 1 1 2 2 2 0 Mitochondrial ATP synthase subunit Pam16 PF03656.13 CDK99935.1 - 0.28 11.2 3.1 0.25 11.4 1.3 1.7 1 1 0 1 1 1 0 Pam16 DUF349 PF03993.12 CDK99935.1 - 0.89 9.9 3.7 22 5.4 0.3 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) HD_5 PF13487.6 CDK99936.1 - 4.8e-22 78.0 0.2 1.2e-21 76.7 0.0 1.8 2 0 0 2 2 2 1 HD domain GAF PF01590.26 CDK99936.1 - 6.3e-12 46.3 0.0 1.8e-11 44.8 0.0 1.8 2 0 0 2 2 2 1 GAF domain HD PF01966.22 CDK99936.1 - 3.7e-09 36.8 0.0 0.00028 21.1 0.0 2.6 2 0 0 2 2 2 2 HD domain GAF_2 PF13185.6 CDK99936.1 - 3.1e-08 34.0 0.0 7e-08 32.9 0.0 1.6 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 CDK99936.1 - 1.2e-06 28.9 0.0 0.00031 21.1 0.0 2.8 3 0 0 3 3 3 1 GAF domain UbiD PF01977.16 CDK99937.1 - 3.1e-170 566.4 0.1 3.6e-170 566.2 0.1 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase PPK2 PF03976.14 CDK99938.1 - 9.6e-137 453.8 10.8 5.5e-86 287.8 3.6 2.0 2 0 0 2 2 2 2 Polyphosphate kinase 2 (PPK2) Thymidylate_kin PF02223.17 CDK99938.1 - 0.00025 20.8 0.0 0.89 9.2 0.0 3.4 3 0 0 3 3 3 2 Thymidylate kinase Zeta_toxin PF06414.12 CDK99938.1 - 0.0022 17.3 0.0 0.027 13.7 0.0 2.5 2 1 1 3 3 3 1 Zeta toxin SOAR PF16533.5 CDK99938.1 - 0.0092 15.9 0.8 0.0092 15.9 0.8 2.3 3 0 0 3 3 3 1 STIM1 Orai1-activating region AAA_18 PF13238.6 CDK99938.1 - 0.014 15.9 0.0 3.9 8.0 0.1 3.3 3 1 0 3 3 3 0 AAA domain DUF190 PF02641.15 CDK99938.1 - 0.13 12.6 0.0 5.7 7.3 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized ACR, COG1993 P2_N PF18628.1 CDK99938.1 - 0.17 11.6 0.0 0.33 10.7 0.0 1.5 1 0 0 1 1 1 0 Viral coat protein P2 N-terminal domain sCache_2 PF17200.4 CDK99939.1 - 2.4e-40 137.9 0.0 2.4e-40 137.9 0.0 2.5 3 0 0 3 3 3 1 Single Cache domain 2 dCache_2 PF08269.11 CDK99939.1 - 1.1e-33 116.7 0.0 1.1e-33 116.7 0.0 3.0 3 1 0 3 3 3 1 Cache domain MCPsignal PF00015.21 CDK99939.1 - 1.8e-28 99.5 30.6 1.8e-28 99.5 30.6 3.5 2 1 1 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Cache_3-Cache_2 PF17201.4 CDK99939.1 - 6.9e-11 41.9 0.0 6.9e-11 41.9 0.0 3.9 2 1 3 5 5 5 1 Cache 3/Cache 2 fusion domain HAMP PF00672.25 CDK99939.1 - 4.4e-06 27.0 4.0 1e-05 25.8 0.1 3.6 3 0 0 3 3 3 1 HAMP domain AAA_13 PF13166.6 CDK99939.1 - 0.0056 15.4 14.1 0.0075 15.0 14.1 1.1 1 0 0 1 1 1 1 AAA domain DUF1664 PF07889.12 CDK99939.1 - 2.2 8.3 16.1 10 6.1 4.8 3.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) TauE PF01925.19 CDK99941.1 - 4.5e-49 167.2 41.4 5.3e-49 167.0 41.4 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Semialdhyde_dh PF01118.24 CDK99942.1 - 2.9e-28 98.8 0.0 4.6e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 CDK99942.1 - 1.1e-21 77.7 0.0 2e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain NAD_binding_10 PF13460.6 CDK99942.1 - 0.0012 18.8 0.0 0.0023 17.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 CDK99942.1 - 0.0061 16.7 0.0 0.019 15.1 0.0 1.9 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 CDK99942.1 - 0.021 14.3 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CDK99942.1 - 0.028 14.7 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DXP_reductoisom PF02670.16 CDK99942.1 - 0.056 14.2 0.0 0.14 12.9 0.0 1.8 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase NmrA PF05368.13 CDK99942.1 - 0.082 12.5 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family Hexapep PF00132.24 CDK99943.1 - 2.4e-19 68.2 16.5 1.1e-08 34.5 1.6 4.0 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDK99943.1 - 4.4e-07 29.5 17.7 3.6e-05 23.4 0.9 4.0 3 1 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase AsmA_2 PF13502.6 CDK99946.1 - 2.6e-18 66.4 15.7 1.9e-17 63.6 3.1 3.9 3 2 1 4 4 4 2 AsmA-like C-terminal region AsmA PF05170.14 CDK99946.1 - 3.5e-17 62.4 0.0 2e-10 40.2 0.0 3.4 2 1 1 3 3 3 3 AsmA family DUF748 PF05359.11 CDK99946.1 - 7.3e-07 29.5 4.7 0.068 13.3 0.1 5.1 4 1 1 5 5 5 2 Domain of Unknown Function (DUF748) sCache_2 PF17200.4 CDK99947.1 - 1.9e-35 122.0 1.7 2e-35 121.9 0.1 1.9 2 0 0 2 2 1 1 Single Cache domain 2 MCPsignal PF00015.21 CDK99947.1 - 4.2e-32 111.3 42.6 9.5e-31 106.9 23.6 4.0 1 1 3 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_2 PF08269.11 CDK99947.1 - 1.5e-31 109.7 3.8 2.3e-31 109.1 0.0 2.5 3 0 0 3 3 3 1 Cache domain Cache_3-Cache_2 PF17201.4 CDK99947.1 - 1.6e-12 47.3 3.9 2.2e-12 46.9 0.0 2.9 2 1 0 2 2 2 1 Cache 3/Cache 2 fusion domain HAMP PF00672.25 CDK99947.1 - 3e-10 40.3 0.3 3e-10 40.3 0.3 4.4 5 0 0 5 5 4 1 HAMP domain DUF3450 PF11932.8 CDK99947.1 - 0.008 15.5 1.9 0.008 15.5 1.9 3.5 3 1 0 3 3 3 2 Protein of unknown function (DUF3450) BLOC1_2 PF10046.9 CDK99947.1 - 0.014 15.7 4.4 2.3 8.6 0.2 3.9 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GHL10 PF02638.15 CDK99947.1 - 0.033 13.3 0.0 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 IGF2_C PF08365.11 CDK99947.1 - 0.055 13.5 0.9 0.13 12.3 0.9 1.6 1 0 0 1 1 1 0 Insulin-like growth factor II E-peptide DUF1664 PF07889.12 CDK99947.1 - 0.09 12.8 14.8 0.34 10.9 0.7 3.7 3 1 1 4 4 3 0 Protein of unknown function (DUF1664) SKA1 PF07160.12 CDK99947.1 - 0.097 12.5 2.2 0.69 9.7 0.2 2.4 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF948 PF06103.11 CDK99947.1 - 0.11 12.8 24.1 0.39 11.0 1.2 5.0 3 1 3 6 6 6 0 Bacterial protein of unknown function (DUF948) AAA_13 PF13166.6 CDK99947.1 - 0.15 10.6 7.0 0.28 9.8 7.0 1.4 1 0 0 1 1 1 0 AAA domain DNA_pol3_alpha PF07733.12 CDK99947.1 - 0.16 11.5 5.8 0.059 13.0 1.3 2.3 2 0 0 2 2 2 0 Bacterial DNA polymerase III alpha NTPase domain Prominin PF05478.11 CDK99947.1 - 0.48 8.3 3.0 0.77 7.6 2.2 1.7 1 1 0 1 1 1 0 Prominin DUF3810 PF12725.7 CDK99947.1 - 0.58 9.5 2.1 3 7.1 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3810) FPP PF05911.11 CDK99947.1 - 0.58 8.3 9.4 1.8 6.7 9.4 1.7 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil APG17 PF04108.12 CDK99947.1 - 1.2 8.2 5.1 2.1 7.4 0.6 2.5 2 1 0 2 2 2 0 Autophagy protein Apg17 COG6 PF06419.11 CDK99947.1 - 2 6.5 5.0 1.7 6.8 0.3 2.4 2 1 1 3 3 3 0 Conserved oligomeric complex COG6 NPV_P10 PF05531.12 CDK99947.1 - 3.2 8.3 14.2 0.57 10.7 0.1 4.0 3 2 1 4 4 3 0 Nucleopolyhedrovirus P10 protein DUF724 PF05266.14 CDK99947.1 - 3.3 7.5 8.4 2.8 7.7 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF724) Laminin_II PF06009.12 CDK99947.1 - 3.7 7.6 22.0 2.5 8.1 5.2 4.1 2 1 0 3 3 3 0 Laminin Domain II DUF3150 PF11348.8 CDK99947.1 - 4.7 6.4 7.5 1.3 8.2 0.4 2.9 2 1 0 3 3 3 0 Protein of unknown function (DUF3150) sCache_2 PF17200.4 CDK99948.1 - 3.3e-38 131.0 0.1 8.3e-38 129.7 0.1 1.7 1 0 0 1 1 1 1 Single Cache domain 2 MCPsignal PF00015.21 CDK99948.1 - 4e-33 114.6 36.5 8.7e-30 103.8 24.5 3.3 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_2 PF08269.11 CDK99948.1 - 9.8e-30 103.7 0.2 5.4e-29 101.3 0.0 2.2 2 0 0 2 2 2 1 Cache domain HAMP PF00672.25 CDK99948.1 - 2.1e-10 40.8 1.5 5.8e-09 36.2 0.2 3.5 2 1 0 2 2 2 1 HAMP domain Cache_3-Cache_2 PF17201.4 CDK99948.1 - 5.7e-09 35.7 1.4 1.2e-08 34.6 0.0 2.3 2 1 1 3 3 3 1 Cache 3/Cache 2 fusion domain DUF1664 PF07889.12 CDK99948.1 - 0.029 14.4 7.6 2.6 8.1 0.3 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) SKA1 PF07160.12 CDK99948.1 - 0.08 12.8 1.5 0.45 10.3 0.3 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF3450 PF11932.8 CDK99948.1 - 0.12 11.7 12.6 0.054 12.8 0.6 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3450) S-AdoMet_synt_N PF00438.20 CDK99948.1 - 0.25 12.0 4.2 0.59 10.8 0.1 2.8 2 1 0 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain BLOC1_2 PF10046.9 CDK99948.1 - 0.67 10.3 8.2 11 6.4 0.2 4.3 3 2 1 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IGF2_C PF08365.11 CDK99948.1 - 0.68 10.0 3.1 1.5 8.9 2.4 2.0 1 1 1 2 2 2 0 Insulin-like growth factor II E-peptide NPV_P10 PF05531.12 CDK99948.1 - 0.68 10.4 7.6 1.1 9.8 0.3 3.6 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TMPIT PF07851.13 CDK99948.1 - 1.1 8.4 2.7 22 4.2 0.2 2.3 1 1 2 3 3 3 0 TMPIT-like protein MCLC PF05934.11 CDK99948.1 - 1.1 7.9 4.4 11 4.5 0.0 2.8 2 1 1 3 3 3 0 Mid-1-related chloride channel (MCLC) Laminin_II PF06009.12 CDK99948.1 - 3.2 7.8 20.8 0.66 10.0 5.1 3.3 2 1 2 4 4 3 0 Laminin Domain II DUF724 PF05266.14 CDK99948.1 - 4.7 7.0 7.5 9.7 6.0 0.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF724) AAA_13 PF13166.6 CDK99948.1 - 5.6 5.5 8.4 12 4.4 8.3 1.6 1 1 0 1 1 1 0 AAA domain DUF948 PF06103.11 CDK99948.1 - 6.4 7.1 25.4 1.3 9.4 0.9 5.2 3 1 3 6 6 6 0 Bacterial protein of unknown function (DUF948) AsnC_trans_reg PF01037.21 CDK99949.1 - 4.2e-20 71.5 0.0 6.7e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 CDK99949.1 - 3.3e-19 68.2 0.1 4.9e-19 67.6 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CDK99949.1 - 3.7e-16 58.7 4.1 5.5e-16 58.1 4.1 1.3 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_20 PF12840.7 CDK99949.1 - 6.1e-06 26.2 0.1 1.1e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 CDK99949.1 - 6.3e-05 22.8 0.1 8.5e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 MarR family MarR PF01047.22 CDK99949.1 - 0.00047 20.0 0.0 0.00071 19.4 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_IclR PF09339.10 CDK99949.1 - 0.0011 18.8 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_39 PF14090.6 CDK99949.1 - 0.0039 16.9 0.1 0.0068 16.1 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 CDK99949.1 - 0.034 14.0 0.0 0.058 13.3 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 CDK99949.1 - 0.036 14.0 0.0 0.079 12.9 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_47 PF16221.5 CDK99949.1 - 0.044 13.4 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 winged helix-turn-helix Rrf2 PF02082.20 CDK99949.1 - 0.12 12.7 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator AhpC-TSA PF00578.21 CDK99950.1 - 7.9e-30 103.3 0.0 1e-29 103.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDK99950.1 - 1e-13 51.3 0.0 1.3e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CDK99950.1 - 1.4e-12 47.3 0.1 2.5e-12 46.4 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin dCache_1 PF02743.18 CDK99951.1 - 1.7e-20 73.9 0.0 3.5e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 Cache domain HATPase_c PF02518.26 CDK99951.1 - 3.3e-19 69.4 0.0 7.3e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDK99951.1 - 2.7e-12 46.6 0.8 7.6e-10 38.7 0.0 3.0 3 1 0 3 3 3 2 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDK99951.1 - 1.7e-11 44.3 3.9 2.8e-11 43.6 0.1 3.1 3 0 0 3 3 3 1 HAMP domain HATPase_c_5 PF14501.6 CDK99951.1 - 0.00068 19.5 0.0 0.0015 18.4 0.0 1.5 1 0 0 1 1 1 1 GHKL domain DUF4200 PF13863.6 CDK99951.1 - 0.1 13.0 0.7 0.18 12.2 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Pyr_redox_2 PF07992.14 CDK99952.1 - 3.3e-50 171.0 3.7 3.7e-50 170.8 3.7 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDK99952.1 - 1.5e-20 73.7 0.9 2.7e-17 63.0 0.0 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDK99952.1 - 5.6e-19 68.5 0.9 3.5e-16 59.5 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDK99952.1 - 1.7e-06 27.4 8.4 0.0051 15.9 0.3 3.9 3 1 0 4 4 4 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 CDK99952.1 - 2.7e-06 27.0 3.2 0.00016 21.2 0.1 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDK99952.1 - 2.9e-05 23.3 12.3 0.00075 18.7 0.3 3.9 2 1 2 4 4 4 2 FAD binding domain DAO PF01266.24 CDK99952.1 - 0.00011 21.9 9.0 0.34 10.4 0.4 3.8 3 2 1 4 4 4 2 FAD dependent oxidoreductase Thi4 PF01946.17 CDK99952.1 - 0.00054 19.3 0.5 0.33 10.2 0.1 2.3 2 0 0 2 2 2 2 Thi4 family NAD_binding_7 PF13241.6 CDK99952.1 - 0.0011 19.4 0.1 0.034 14.6 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 CDK99952.1 - 0.0028 17.0 1.9 1.2 8.3 0.3 2.3 2 1 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 CDK99952.1 - 0.0036 16.2 2.0 4.4 6.0 0.2 3.0 3 0 0 3 3 3 1 Tryptophan halogenase HI0933_like PF03486.14 CDK99952.1 - 0.0037 16.0 1.7 0.26 10.0 0.2 2.9 4 0 0 4 4 4 1 HI0933-like protein Shikimate_DH PF01488.20 CDK99952.1 - 0.01 15.9 0.2 1.2 9.1 0.0 2.8 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FMO-like PF00743.19 CDK99952.1 - 0.011 14.2 0.0 0.016 13.6 0.0 1.3 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 CDK99952.1 - 0.011 14.9 0.1 0.23 10.6 0.1 2.2 1 1 1 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CDK99952.1 - 0.049 13.9 0.0 0.049 13.9 0.0 2.6 3 0 0 3 3 2 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CDK99952.1 - 0.054 13.5 3.6 0.35 10.9 0.0 3.2 4 0 0 4 4 4 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CDK99952.1 - 0.14 11.3 1.3 0.46 9.7 0.2 2.1 2 0 0 2 2 2 0 FAD binding domain DUF2190 PF09956.9 CDK99952.1 - 0.57 10.7 8.0 0.079 13.5 2.5 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2190) Attacin_N PF03768.15 CDK99952.1 - 1.3 9.2 5.6 2.6 8.3 3.3 2.5 1 1 1 2 2 2 0 Attacin, N-terminal region LysR_substrate PF03466.20 CDK99953.1 - 7.3e-38 130.0 0.0 9e-38 129.7 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDK99953.1 - 7.4e-23 80.3 0.3 1.2e-22 79.7 0.3 1.3 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_5 PF01022.20 CDK99953.1 - 0.049 13.5 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 CDK99953.1 - 0.11 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Redoxin PF08534.10 CDK99958.1 - 9.5e-21 74.1 0.0 1.2e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CDK99958.1 - 1.9e-20 73.0 0.0 2.4e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 CDK99958.1 - 8.6e-11 42.0 0.0 1.4e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 CDK99958.1 - 2.1e-07 30.8 0.0 2.7e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 CDK99958.1 - 1.9e-05 25.1 0.0 3.9e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain GSHPx PF00255.19 CDK99958.1 - 0.00081 18.9 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin_9 PF14595.6 CDK99958.1 - 0.014 15.2 0.0 0.11 12.3 0.0 2.2 2 1 1 3 3 3 0 Thioredoxin ABC_transp_aux PF09822.9 CDK99960.1 - 0.0012 18.4 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DUF4350 PF14258.6 CDK99960.1 - 0.0024 18.3 0.8 0.014 15.8 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4350) Prim-Pol PF09250.11 CDK99963.1 - 4e-20 72.8 1.5 8.9e-20 71.6 0.1 2.2 3 0 0 3 3 3 1 Bifunctional DNA primase/polymerase, N-terminal HTH_17 PF12728.7 CDK99964.1 - 2.3e-11 43.7 0.0 2.6e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain MerR_1 PF13411.6 CDK99964.1 - 0.056 13.6 0.0 0.067 13.3 0.0 1.2 1 0 0 1 1 1 0 MerR HTH family regulatory protein HTH_23 PF13384.6 CDK99964.1 - 0.058 13.2 0.0 0.082 12.7 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4_2 PF08281.12 CDK99964.1 - 0.072 12.8 0.0 0.26 11.0 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 RWP-RK PF02042.15 CDK99964.1 - 0.14 12.2 0.1 0.2 11.7 0.1 1.2 1 0 0 1 1 1 0 RWP-RK domain Phage_integrase PF00589.22 CDK99965.1 - 4.1e-17 62.5 0.0 8.6e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family Arm-DNA-bind_3 PF13356.6 CDK99965.1 - 2.2e-16 60.0 0.8 5e-16 58.8 0.8 1.6 1 0 0 1 1 1 1 Arm DNA-binding domain Phage_integr_3 PF16795.5 CDK99965.1 - 0.025 14.5 0.0 0.076 12.9 0.0 1.8 2 0 0 2 2 2 0 Archaeal phage integrase Phage_int_SAM_3 PF14659.6 CDK99965.1 - 0.028 14.7 0.0 0.11 12.7 0.0 2.1 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain YchF-GTPase_C PF06071.13 CDK99966.1 - 9.1e-42 141.2 0.1 2.1e-41 140.0 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CDK99966.1 - 1.9e-24 86.0 0.0 4.2e-24 84.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDK99966.1 - 3.4e-08 33.2 0.2 1.2e-07 31.4 0.0 2.1 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CDK99966.1 - 0.15 12.1 0.0 16 5.5 0.0 2.3 1 1 1 2 2 2 0 Dynamin family Pept_tRNA_hydro PF01195.19 CDK99967.1 - 2e-55 187.3 0.0 2.5e-55 187.0 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Ribosomal_TL5_C PF14693.6 CDK99968.1 - 3.4e-24 85.0 2.8 5.4e-24 84.4 2.8 1.3 1 0 0 1 1 1 1 Ribosomal protein TL5, C-terminal domain Ribosomal_L25p PF01386.19 CDK99968.1 - 1.5e-23 83.1 0.0 3.7e-23 81.8 0.0 1.7 2 0 0 2 2 2 1 Ribosomal L25p family SBP_bac_5 PF00496.22 CDK99969.1 - 9e-60 202.6 0.0 1.2e-59 202.2 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle Saf_2TM PF18303.1 CDK99970.1 - 0.12 11.9 2.5 0.16 11.6 2.5 1.0 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Phage_holin_3_6 PF07332.11 CDK99970.1 - 1.2 9.2 7.0 1.6 8.8 7.0 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Acetyltransf_1 PF00583.25 CDK99971.1 - 1.3e-15 57.6 0.0 2e-15 57.0 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDK99971.1 - 1.4e-11 44.5 0.0 1.6e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDK99971.1 - 4.7e-08 33.3 0.0 6.6e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDK99971.1 - 1.1e-05 25.5 0.0 2.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 CDK99971.1 - 0.0082 16.1 0.0 0.07 13.1 0.0 2.0 2 0 0 2 2 2 1 FR47-like protein Benyvirus_P25 PF05744.11 CDK99971.1 - 0.034 13.5 0.0 0.037 13.3 0.0 1.1 1 0 0 1 1 1 0 Benyvirus P25/P26 protein Acetyltransf_6 PF13480.7 CDK99971.1 - 0.079 13.1 3.3 0.12 12.5 3.1 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain TetR_C_11 PF16859.5 CDK99972.1 - 2.2e-15 56.9 4.7 2.2e-15 56.9 4.7 1.5 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_N PF00440.23 CDK99972.1 - 5.4e-14 51.7 0.0 1e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family HTH_Tnp_1_2 PF13022.6 CDK99972.1 - 0.00021 21.5 0.0 0.00033 20.8 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase TetR_C_6 PF13977.6 CDK99972.1 - 0.0011 19.1 2.9 0.0011 19.1 2.9 1.9 2 0 0 2 2 2 1 BetI-type transcriptional repressor, C-terminal TetR_C_7 PF14246.6 CDK99972.1 - 0.0077 16.3 0.3 0.015 15.3 0.3 1.5 1 0 0 1 1 1 1 AefR-like transcriptional repressor, C-terminal domain HTH_28 PF13518.6 CDK99972.1 - 0.009 16.1 0.5 0.025 14.7 0.5 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.15 CDK99972.1 - 0.031 14.4 0.0 0.061 13.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 CDK99972.1 - 0.034 13.9 0.5 0.081 12.7 0.5 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_17 PF12728.7 CDK99972.1 - 0.09 13.0 0.0 0.23 11.7 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_3 PF01381.22 CDK99972.1 - 0.17 12.0 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix ChaC PF04752.12 CDK99973.1 - 2.6e-18 66.7 0.0 2.9e-18 66.5 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein GGACT PF06094.12 CDK99973.1 - 0.00013 22.5 0.0 0.00018 22.1 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 CDK99973.1 - 0.01 16.2 0.0 0.013 15.9 0.0 1.2 1 0 0 1 1 1 0 AIG2-like family mTERF PF02536.14 CDK99973.1 - 0.25 10.3 0.0 0.3 10.0 0.0 1.1 1 0 0 1 1 1 0 mTERF DUF2125 PF09898.9 CDK99974.1 - 5.2e-61 207.1 21.3 6.1e-61 206.8 21.3 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2125) AsmA_2 PF13502.6 CDK99974.1 - 0.0051 16.4 0.0 1.9 7.9 0.0 2.7 3 0 0 3 3 3 2 AsmA-like C-terminal region FAD_syn PF06574.12 CDK99975.1 - 1.2e-48 165.0 0.0 1.6e-48 164.6 0.0 1.2 1 0 0 1 1 1 1 FAD synthetase Flavokinase PF01687.17 CDK99975.1 - 1.2e-38 131.8 0.0 1.9e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Riboflavin kinase CTP_transf_like PF01467.26 CDK99975.1 - 0.016 15.4 0.2 0.078 13.2 0.1 2.1 1 1 1 2 2 2 0 Cytidylyltransferase-like tRNA-synt_1 PF00133.22 CDK99976.1 - 5.6e-185 616.1 0.0 6.6e-185 615.8 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDK99976.1 - 2.6e-21 76.2 0.0 4.2e-21 75.5 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDK99976.1 - 6.7e-20 71.2 0.0 1.3e-10 40.6 0.0 3.5 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CDK99976.1 - 5.2e-08 32.6 0.0 0.00054 19.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 CDK99976.1 - 6.5e-06 25.3 0.0 8.1e-05 21.7 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (K) zf-FPG_IleRS PF06827.14 CDK99976.1 - 0.00015 21.6 2.9 0.00029 20.6 2.9 1.5 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS tRNA-synt_1_2 PF13603.6 CDK99976.1 - 0.0022 17.5 0.0 0.0041 16.7 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 Peptidase_A8 PF01252.18 CDK99977.1 - 1.3e-38 132.4 6.1 1.5e-38 132.2 6.1 1.0 1 0 0 1 1 1 1 Signal peptidase (SPase) II MurJ PF03023.14 CDK99977.1 - 0.079 11.5 2.3 0.11 11.1 2.3 1.2 1 0 0 1 1 1 0 Lipid II flippase MurJ DUF3017 PF11222.8 CDK99977.1 - 3.2 8.1 9.9 0.38 11.0 4.8 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3017) DUF3035 PF11233.8 CDK99978.1 - 6.4e-48 162.6 4.6 8e-48 162.3 4.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3035) DDE_3 PF13358.6 CDK99979.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDK99979.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDK99980.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDK99980.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDK99980.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDK99980.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDK99980.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDK99980.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain Peptidase_M16_C PF05193.21 CDK99982.1 - 5.9e-31 107.9 0.0 9.1e-31 107.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CDK99982.1 - 7.7e-25 87.6 0.0 1.3e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CDK99983.1 - 3.5e-31 108.6 0.0 5.9e-30 104.6 0.0 2.2 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CDK99983.1 - 0.00034 20.6 0.0 0.00058 19.9 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 CDK99983.1 - 0.17 11.0 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Peptidase M16C associated GSHPx PF00255.19 CDK99984.1 - 1.4e-29 101.8 0.0 1.9e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase DUF3429 PF11911.8 CDK99985.1 - 9.2e-36 123.3 15.7 1.2e-35 122.9 15.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) DUF3084 PF11283.8 CDK99985.1 - 0.22 11.5 0.1 0.22 11.5 0.1 1.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3084) DUF751 PF05421.11 CDK99985.1 - 3.2 8.5 7.4 0.72 10.6 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF751) GTP_cyclohydroI PF01227.22 CDK99986.1 - 1.6e-77 259.0 0.2 1.8e-77 258.8 0.2 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 CDK99986.1 - 0.00021 21.4 0.0 0.00036 20.6 0.0 1.4 1 0 0 1 1 1 1 QueF-like protein EIF_2_alpha PF07541.12 CDK99986.1 - 0.081 13.0 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Amino_oxidase PF01593.24 CDK99987.1 - 3.9e-17 62.7 0.2 2.7e-16 59.9 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CDK99987.1 - 4.6e-14 52.4 0.1 1e-13 51.2 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDK99987.1 - 0.00052 19.7 5.6 0.0016 18.1 1.2 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDK99987.1 - 0.022 14.0 0.1 0.044 13.0 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDK99987.1 - 0.029 14.4 0.6 3.5 7.6 0.1 2.5 2 1 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CDK99987.1 - 0.031 13.4 0.3 0.048 12.7 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 CDK99987.1 - 0.073 12.3 0.1 9.5 5.4 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDK99987.1 - 0.077 11.7 0.2 0.14 10.9 0.2 1.3 1 0 0 1 1 1 0 HI0933-like protein DUF1365 PF07103.11 CDK99988.1 - 5.3e-66 222.7 0.0 6.1e-66 222.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) CMAS PF02353.20 CDK99989.1 - 3.9e-86 288.7 0.0 4.7e-86 288.5 0.0 1.0 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CDK99989.1 - 1.9e-12 47.3 0.0 3.4e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDK99989.1 - 2.3e-12 47.4 0.0 5.4e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDK99989.1 - 2.3e-11 44.2 0.0 4.7e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDK99989.1 - 2.4e-07 31.4 0.0 4.8e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDK99989.1 - 0.0012 18.6 0.0 0.0019 18.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CDK99989.1 - 0.0015 18.3 0.0 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CDK99989.1 - 0.011 15.9 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase MTS PF05175.14 CDK99989.1 - 0.25 10.9 0.0 0.38 10.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain MFS_2 PF13347.6 CDK99990.1 - 1.2e-66 225.1 16.5 1.5e-66 224.8 16.5 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 CDK99990.1 - 8.7e-13 47.9 47.0 5.9e-07 28.7 23.4 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF2770 PF10968.8 CDK99990.1 - 1.7 8.7 4.3 14 5.8 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2770) DUF3833 PF12915.7 CDK99991.1 - 1.5e-68 229.6 0.8 1.7e-68 229.3 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3833) LPAM_1 PF08139.12 CDK99991.1 - 0.25 11.9 1.4 0.5 10.9 1.4 1.5 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site SnoaL_2 PF12680.7 CDK99992.1 - 9.1e-07 29.5 0.9 1.2e-06 29.0 0.9 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 CDK99992.1 - 0.016 15.0 0.1 0.046 13.5 0.1 1.6 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase adh_short PF00106.25 CDK99993.1 - 7e-48 162.7 0.0 8.5e-48 162.4 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDK99993.1 - 3.6e-33 115.1 0.2 4.3e-33 114.8 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDK99993.1 - 7.2e-13 48.8 0.2 9.6e-13 48.4 0.2 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CDK99993.1 - 8.5e-09 35.6 0.3 1.1e-08 35.2 0.3 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CDK99993.1 - 1.5e-07 31.2 0.0 7.9e-07 28.8 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 CDK99993.1 - 0.00021 21.8 0.0 0.0004 20.9 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 CDK99993.1 - 0.0022 18.3 0.0 0.0031 17.8 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 CDK99993.1 - 0.0024 17.0 0.0 0.0035 16.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain ApbA PF02558.16 CDK99993.1 - 0.037 13.7 0.1 0.063 12.9 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF4198 PF10670.9 CDK99994.1 - 0.04 14.3 0.0 0.058 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) LEA_2 PF03168.13 CDK99994.1 - 0.055 14.0 0.1 3 8.4 0.0 2.3 2 0 0 2 2 2 0 Late embryogenesis abundant protein Cupin_7 PF12973.7 CDK99995.1 - 1.7e-12 47.1 0.0 2.4e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 ChrR Cupin-like domain Cupin_2 PF07883.11 CDK99995.1 - 0.00026 20.6 0.1 0.00093 18.9 0.1 1.8 1 1 0 1 1 1 1 Cupin domain zf-HC2 PF13490.6 CDK99995.1 - 0.0079 16.4 0.6 0.0079 16.4 0.6 2.2 2 0 0 2 2 2 1 Putative zinc-finger Sigma70_r2 PF04542.14 CDK99996.1 - 6.7e-22 77.0 0.2 1.6e-21 75.8 0.3 1.6 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 CDK99996.1 - 4e-15 55.2 0.0 6.5e-15 54.5 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 CDK99996.1 - 9.8e-15 53.8 0.1 2e-14 52.9 0.0 1.6 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 CDK99996.1 - 9e-05 22.4 0.0 0.00052 19.9 0.0 2.0 1 1 0 1 1 1 1 ECF sigma factor HTH_24 PF13412.6 CDK99996.1 - 0.00082 18.9 0.0 0.0046 16.5 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding GerE PF00196.19 CDK99996.1 - 0.046 13.3 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family RPT PF13446.6 CDK99997.1 - 0.071 13.0 0.1 0.095 12.6 0.1 1.4 1 1 0 1 1 1 0 A repeated domain in UCH-protein ExoD PF06055.12 CDK99998.1 - 2.7e-34 118.1 15.1 3.1e-34 117.9 15.1 1.0 1 0 0 1 1 1 1 Exopolysaccharide synthesis, ExoD TerC PF03741.16 CDK99999.1 - 3.8e-55 186.4 8.9 3.8e-55 186.4 8.9 1.7 2 0 0 2 2 2 1 Integral membrane protein TerC family DUF1476 PF07345.11 CDL00000.1 - 9.9e-22 77.2 0.1 1.1e-21 77.1 0.1 1.0 1 0 0 1 1 1 1 ATPase inhibitor subunit zeta ABC_export PF16962.5 CDL00001.1 - 0.0047 15.4 0.6 0.0049 15.4 0.6 1.0 1 0 0 1 1 1 1 Putative ABC exporter Tetraspanin PF00335.20 CDL00001.1 - 0.067 12.9 0.3 0.075 12.7 0.3 1.0 1 0 0 1 1 1 0 Tetraspanin family Gram_pos_anchor PF00746.21 CDL00001.1 - 0.63 10.0 7.1 6.2 6.9 1.2 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF202 PF02656.15 CDL00001.1 - 0.69 10.4 4.6 8.9 6.8 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF3899 PF13038.6 CDL00001.1 - 2.1 8.9 5.1 30 5.2 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3899) DUF5516 PF17637.2 CDL00001.1 - 8.4 6.2 7.4 49 3.8 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5516) TGT_C1 PF14809.6 CDL00002.1 - 0.031 14.6 0.0 0.036 14.4 0.0 1.1 1 0 0 1 1 1 0 C1 domain of tRNA-guanine transglycosylase dimerisation PPK2 PF03976.14 CDL00003.1 - 1.8e-63 214.1 0.4 3.6e-63 213.1 0.4 1.4 1 1 0 1 1 1 1 Polyphosphate kinase 2 (PPK2) LTXXQ PF07813.12 CDL00004.1 - 8e-09 36.2 0.4 8e-09 36.2 0.4 2.1 2 1 0 2 2 2 1 LTXXQ motif family protein DUF5329 PF17263.2 CDL00006.1 - 5.5e-33 113.0 0.1 6.5e-33 112.8 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5329) Cys_Met_Meta_PP PF01053.20 CDL00007.1 - 1.1e-100 336.8 0.0 1.5e-100 336.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CDL00007.1 - 5.3e-05 22.3 0.0 8.2e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CDL00007.1 - 0.0001 21.6 0.0 0.00017 20.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CDL00007.1 - 0.097 11.9 0.2 0.73 9.1 0.2 2.1 1 1 0 1 1 1 0 Beta-eliminating lyase GDC-P PF02347.16 CDL00007.1 - 0.14 11.0 0.0 0.2 10.5 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein OsmC PF02566.19 CDL00008.1 - 7.5e-17 61.7 0.0 1.3e-16 60.9 0.0 1.4 2 0 0 2 2 2 1 OsmC-like protein AMP-binding PF00501.28 CDL00009.1 - 3.6e-92 309.1 0.0 4.3e-92 308.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDL00009.1 - 2.1e-23 83.1 0.3 4.6e-23 82.0 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 CDL00009.1 - 2.1e-18 65.9 0.2 2.1e-18 65.9 0.2 2.5 3 0 0 3 3 3 1 Acetyl-coenzyme A synthetase N-terminus ABC_tran PF00005.27 CDL00010.1 - 1.2e-34 119.7 0.0 1.6e-34 119.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDL00010.1 - 6.2e-05 23.0 0.2 0.087 12.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CDL00010.1 - 0.0052 16.7 0.1 0.0084 16.1 0.1 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 CDL00010.1 - 0.022 15.0 0.4 0.11 12.8 0.4 2.0 1 1 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 CDL00010.1 - 0.068 12.0 0.2 6.2 5.5 0.0 2.5 2 1 0 2 2 2 0 Predicted ATPase of the ABC class AAA_29 PF13555.6 CDL00010.1 - 0.072 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDL00010.1 - 0.11 12.4 0.3 0.17 11.8 0.3 1.2 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 CDL00010.1 - 0.14 11.9 0.2 0.18 11.5 0.2 1.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDL00010.1 - 0.21 11.9 1.2 0.35 11.2 1.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain BPD_transp_1 PF00528.22 CDL00011.1 - 7.3e-19 68.2 15.2 1.1e-18 67.6 15.2 1.3 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Romo1 PF10247.9 CDL00011.1 - 0.027 14.8 0.7 0.065 13.6 0.0 2.0 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 NMT1 PF09084.11 CDL00012.1 - 8.3e-27 94.5 0.0 1.4e-26 93.8 0.0 1.3 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 CDL00012.1 - 2.1e-11 44.0 0.1 1.9e-10 40.9 0.1 2.2 1 1 0 1 1 1 1 NMT1-like family SBP_bac_3 PF00497.20 CDL00012.1 - 7.6e-08 32.1 0.4 1.8e-07 30.9 0.0 1.9 1 1 1 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 Phosphonate-bd PF12974.7 CDL00012.1 - 2.1e-07 30.8 0.5 5.3e-07 29.5 0.1 1.8 1 1 1 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1_3 PF16868.5 CDL00012.1 - 3.5e-05 23.4 0.0 0.00011 21.7 0.0 1.8 1 1 0 1 1 1 1 NMT1-like family DUF2639 PF11121.8 CDL00012.1 - 0.097 12.7 0.4 0.25 11.4 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2639) CbiJ PF02571.14 CDL00013.1 - 3.4e-68 229.6 0.0 3.8e-68 229.5 0.0 1.0 1 0 0 1 1 1 1 Precorrin-6x reductase CbiJ/CobK GARS_N PF02844.15 CDL00013.1 - 0.015 16.1 0.0 0.033 14.9 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain ATPgrasp_N PF18130.1 CDL00013.1 - 0.024 15.2 0.0 0.094 13.3 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp N-terminal domain CbiD PF01888.17 CDL00014.1 - 4e-87 291.7 0.5 4e-87 291.7 0.5 1.4 2 0 0 2 2 2 1 CbiD LpxI_N PF17930.1 CDL00014.1 - 0.056 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 LpxI N-terminal domain 4HBT PF03061.22 CDL00015.1 - 1.8e-11 44.2 0.1 3.8e-11 43.2 0.1 1.5 2 0 0 2 2 2 1 Thioesterase superfamily DUF4442 PF14539.6 CDL00015.1 - 9.6e-07 29.0 0.7 1.1e-06 28.8 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) 4HBT_3 PF13622.6 CDL00015.1 - 0.0012 19.1 0.1 0.0015 18.8 0.1 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily ECH_1 PF00378.20 CDL00016.1 - 4.9e-56 189.8 1.1 5.5e-56 189.7 1.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDL00016.1 - 4e-37 128.5 0.9 1.2e-32 113.8 0.8 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase HTH_25 PF13413.6 CDL00017.1 - 2.2e-18 65.8 0.1 3.7e-18 65.1 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4115 PF13464.6 CDL00017.1 - 2.8e-18 65.9 0.2 6.9e-18 64.6 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4115) HTH_19 PF12844.7 CDL00017.1 - 2.7e-07 30.5 0.0 4.4e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 CDL00017.1 - 1.3e-05 25.4 0.8 3e-05 24.3 0.8 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain MoaE PF02391.17 CDL00018.1 - 1.3e-32 112.4 0.0 1.6e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 MoaE protein ThiS PF02597.20 CDL00019.1 - 1.6e-19 70.3 0.0 1.8e-19 70.1 0.0 1.0 1 0 0 1 1 1 1 ThiS family MoeA_N PF03453.17 CDL00020.1 - 6.6e-45 152.7 0.8 9.7e-45 152.1 0.8 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 CDL00020.1 - 5.2e-28 97.5 0.0 9.6e-28 96.7 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_C PF03454.15 CDL00020.1 - 7.2e-17 61.3 0.0 1.6e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Sugarporin_N PF11471.8 CDL00020.1 - 0.19 11.7 0.3 0.41 10.6 0.0 1.7 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension S_layer_C PF05124.12 CDL00020.1 - 0.25 11.3 0.4 0.35 10.8 0.4 1.1 1 0 0 1 1 1 0 S-layer like family, C-terminal region MobB PF03205.14 CDL00021.1 - 2.5e-50 169.8 0.0 3.1e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.23 CDL00021.1 - 0.00032 20.7 0.0 0.00032 20.7 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.19 CDL00021.1 - 0.0017 18.0 0.0 0.003 17.2 0.0 1.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CDL00021.1 - 0.0027 17.9 0.0 0.003 17.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 CDL00021.1 - 0.0034 17.2 0.0 0.0045 16.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.15 CDL00021.1 - 0.0053 16.7 0.0 0.0069 16.3 0.0 1.3 1 0 0 1 1 1 1 NTPase AAA_30 PF13604.6 CDL00021.1 - 0.022 14.5 0.4 0.025 14.3 0.4 1.3 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDL00021.1 - 0.023 14.4 0.4 0.041 13.6 0.4 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 CDL00021.1 - 0.037 13.9 0.3 0.064 13.2 0.3 1.3 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 CDL00021.1 - 0.043 14.3 0.2 0.045 14.3 0.2 1.3 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 CDL00021.1 - 0.053 13.4 0.3 0.084 12.8 0.3 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 CDL00021.1 - 0.068 13.7 0.0 0.1 13.1 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDL00021.1 - 0.072 13.5 0.0 0.085 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain KTI12 PF08433.10 CDL00021.1 - 0.098 12.1 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_26 PF13500.6 CDL00021.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CDL00021.1 - 0.13 11.2 0.3 0.18 10.8 0.3 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 CDL00021.1 - 0.16 11.8 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase ATP_bind_1 PF03029.17 CDL00021.1 - 0.18 11.5 0.2 0.3 10.8 0.2 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein SRP54 PF00448.22 CDL00021.1 - 0.21 11.2 0.6 0.35 10.5 0.6 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_23 PF13476.6 CDL00021.1 - 0.39 11.2 0.5 0.58 10.6 0.5 1.2 1 0 0 1 1 1 0 AAA domain CDP-OH_P_transf PF01066.21 CDL00022.1 - 3e-18 66.4 0.6 3e-18 66.4 0.6 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase UvrC_HhH_N PF08459.11 CDL00023.1 - 1.7e-52 177.4 0.0 3.5e-52 176.4 0.0 1.6 1 0 0 1 1 1 1 UvrC Helix-hairpin-helix N-terminal GIY-YIG PF01541.24 CDL00023.1 - 7.1e-10 39.0 0.0 1.8e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 GIY-YIG catalytic domain UVR PF02151.19 CDL00023.1 - 4.6e-07 29.4 4.8 9.5e-07 28.4 4.8 1.5 1 0 0 1 1 1 1 UvrB/uvrC motif HHH_5 PF14520.6 CDL00023.1 - 7.3e-07 29.7 0.2 2.7e-06 27.9 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_2 PF12826.7 CDL00023.1 - 4.8e-05 23.4 0.0 0.00011 22.2 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH PF00633.23 CDL00023.1 - 0.00089 19.0 0.2 0.0074 16.1 0.0 2.6 3 0 0 3 3 3 1 Helix-hairpin-helix motif HHH_3 PF12836.7 CDL00023.1 - 0.1 12.9 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF3828 PF12883.7 CDL00023.1 - 0.21 12.0 0.1 2.2 8.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3828) adh_short PF00106.25 CDL00025.1 - 4.2e-37 127.5 0.0 4.9e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDL00025.1 - 7.1e-35 120.7 1.2 8.1e-35 120.5 1.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDL00025.1 - 1e-09 38.5 0.3 1.6e-09 38.0 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CDL00025.1 - 0.036 13.5 0.1 0.048 13.1 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 CDL00025.1 - 0.077 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Pkinase PF00069.25 CDL00026.1 - 1.5e-26 93.3 0.0 2.7e-26 92.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDL00026.1 - 3.3e-17 62.6 0.0 4.5e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDL00026.1 - 0.042 13.8 0.0 0.67 9.8 0.0 2.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 CDL00026.1 - 0.075 12.3 0.0 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Pkinase PF00069.25 CDL00027.1 - 2.3e-31 109.1 0.0 3.2e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDL00027.1 - 6.3e-21 74.8 0.0 8.1e-21 74.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDL00027.1 - 6.7e-07 28.4 0.0 9.6e-07 27.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDL00027.1 - 0.00017 21.6 1.5 0.00029 20.8 0.3 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDL00027.1 - 0.0011 18.3 0.0 0.0054 16.1 0.0 2.0 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 CDL00027.1 - 0.0053 16.1 0.0 0.0089 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Cadherin_5 PF17892.1 CDL00028.1 - 0 992.4 291.0 1.7e-33 114.5 7.2 23.7 21 2 2 23 23 23 18 Cadherin-like domain Big_9 PF17963.1 CDL00028.1 - 2.2e-171 557.2 542.8 3.6e-19 69.3 12.6 32.2 28 6 1 30 30 24 20 Bacterial Ig domain Cadherin_4 PF17803.1 CDL00028.1 - 1.2e-71 237.3 537.7 2.6e-12 47.2 8.0 33.1 27 9 4 31 31 21 19 Bacterial cadherin-like domain HemolysinCabind PF00353.19 CDL00028.1 - 1.6e-65 216.5 332.4 2.4e-09 37.0 17.0 26.8 22 6 5 27 27 27 15 RTX calcium-binding nonapeptide repeat (4 copies) AFP_2 PF18815.1 CDL00028.1 - 2.2e-27 95.0 2.6 2.2e-27 95.0 2.6 21.6 22 5 6 28 28 27 1 Bacterial antifreeze protein repeat Leucyl-specific PF14795.6 CDL00028.1 - 6.6e-12 45.3 0.0 54 4.0 0.0 9.2 9 0 0 9 9 9 0 Leucine-tRNA synthetase-specific domain He_PIG PF05345.12 CDL00028.1 - 3.6e-06 27.1 0.6 3.6e-06 27.1 0.6 21.2 26 3 1 27 27 25 2 Putative Ig domain CBM26 PF16738.5 CDL00028.1 - 0.00041 20.6 4.2 3.9e+02 1.4 0.0 8.5 8 0 0 8 8 8 0 Starch-binding module 26 Cadherin_3 PF16184.5 CDL00028.1 - 0.0011 18.9 61.7 0.075 13.0 0.1 16.0 18 1 0 18 18 18 4 Cadherin-like HU-CCDC81_bac_2 PF18175.1 CDL00028.1 - 0.064 13.1 6.0 1.1e+02 2.8 0.0 6.8 8 0 0 8 8 8 0 CCDC81-like prokaryotic HU domain 2 DUF1416 PF07210.12 CDL00028.1 - 0.29 11.0 31.6 1.3 9.0 1.4 6.4 5 0 0 5 5 5 0 Protein of unknown function (DUF1416) GldM_C PF12080.8 CDL00028.1 - 7.4 6.8 19.4 3.1 8.0 0.1 7.4 7 0 0 7 7 6 0 GldM C-terminal domain UvrB_inter PF17757.1 CDL00029.1 - 1.9e-32 111.3 0.0 1.4e-31 108.5 0.0 2.3 2 0 0 2 2 2 1 UvrB interaction domain UvrB PF12344.8 CDL00029.1 - 5.1e-22 77.4 0.1 5.1e-22 77.4 0.1 1.8 2 0 0 2 2 2 1 Ultra-violet resistance protein B Helicase_C PF00271.31 CDL00029.1 - 5.5e-19 68.6 0.1 1.6e-18 67.1 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDL00029.1 - 8.7e-11 42.1 0.0 4.1e-10 39.9 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UVR PF02151.19 CDL00029.1 - 1.8e-07 30.6 9.2 6.3e-07 28.9 9.2 1.9 1 0 0 1 1 1 1 UvrB/uvrC motif AAA_30 PF13604.6 CDL00029.1 - 5.3e-05 23.0 0.1 0.0022 17.8 0.0 3.2 4 0 0 4 4 4 1 AAA domain DEAD PF00270.29 CDL00029.1 - 0.00045 20.0 0.0 0.0014 18.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase UB2H PF14814.6 CDL00029.1 - 0.0055 16.7 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 Bifunctional transglycosylase second domain AAA_19 PF13245.6 CDL00029.1 - 0.024 15.0 0.1 0.76 10.1 0.0 2.8 3 0 0 3 3 2 0 AAA domain eIF3_p135 PF12807.7 CDL00029.1 - 0.024 14.7 0.1 0.056 13.5 0.1 1.5 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 Microtub_bd PF16796.5 CDL00029.1 - 0.049 13.6 0.0 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 Microtubule binding Kinesin PF00225.23 CDL00029.1 - 0.09 11.7 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinesin motor domain P5CR_dimer PF14748.6 CDL00030.1 - 7.3e-31 106.5 6.0 1.4e-30 105.6 6.0 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CDL00030.1 - 4.7e-08 33.5 0.8 2.4e-07 31.3 0.2 2.4 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent YbjN PF10722.9 CDL00031.1 - 8.4e-36 122.8 0.0 1e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Putative bacterial sensory transduction regulator BMFP PF04380.13 CDL00032.1 - 4e-26 91.3 1.4 4.7e-26 91.1 1.4 1.0 1 0 0 1 1 1 1 Membrane fusogenic activity DUF3583 PF12126.8 CDL00032.1 - 3.6e-05 23.4 0.1 4.1e-05 23.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3583) DUF3052 PF11253.8 CDL00032.1 - 0.082 12.8 0.0 0.1 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) Epimerase PF01370.21 CDL00033.1 - 4.5e-38 131.1 0.0 6.8e-38 130.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDL00033.1 - 1.5e-15 57.5 0.0 2.3e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CDL00033.1 - 1e-09 37.9 0.0 1.7e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CDL00033.1 - 3e-08 33.0 0.0 2.9e-07 29.8 0.0 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CDL00033.1 - 3.4e-07 29.7 0.0 0.043 12.9 0.1 3.3 2 2 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CDL00033.1 - 0.00029 20.1 0.0 0.35 10.0 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein KR PF08659.10 CDL00033.1 - 0.055 13.4 0.1 0.15 12.0 0.1 1.8 1 1 0 1 1 1 0 KR domain NAD_binding_3 PF03447.16 CDL00033.1 - 0.079 13.6 0.0 0.14 12.8 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain LGT PF01790.18 CDL00034.1 - 2.8e-76 256.0 9.5 3.1e-76 255.8 9.5 1.0 1 0 0 1 1 1 1 Prolipoprotein diacylglyceryl transferase Methyltransf_28 PF02636.17 CDL00035.1 - 4e-65 220.1 0.0 1.3e-64 218.3 0.0 1.7 2 0 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Mur_ligase_C PF02875.21 CDL00035.1 - 0.045 14.0 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Cu-oxidase_4 PF02578.15 CDL00036.1 - 3.5e-68 229.7 0.0 4e-68 229.5 0.0 1.0 1 0 0 1 1 1 1 Multi-copper polyphenol oxidoreductase laccase Glyco_hydro_3_C PF01915.22 CDL00037.1 - 0.075 13.0 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain Pribosyltran_N PF13793.6 CDL00038.1 - 3.4e-49 165.6 1.5 2.4e-48 162.9 0.1 2.5 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CDL00038.1 - 1.1e-26 94.0 2.3 1.6e-25 90.2 0.4 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CDL00038.1 - 1.3e-18 67.0 2.4 3.5e-18 65.6 2.4 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain RibD_C PF01872.17 CDL00039.1 - 4e-17 62.7 0.0 2.2e-15 57.0 0.0 2.0 1 1 0 1 1 1 1 RibD C-terminal domain DHFR_1 PF00186.19 CDL00039.1 - 3.6e-06 26.8 0.0 4.2e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase Methyltransf_25 PF13649.6 CDL00040.1 - 4.5e-14 52.9 0.0 7.4e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00040.1 - 6.3e-13 49.3 0.0 9.7e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL00040.1 - 3.2e-10 40.5 0.0 5.2e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00040.1 - 1.6e-09 37.7 0.0 1.8e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL00040.1 - 4e-08 33.3 0.0 4.8e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDL00040.1 - 0.00053 19.4 0.0 0.00084 18.7 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family 3HCDH_N PF02737.18 CDL00040.1 - 0.0065 16.4 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_4 PF02390.17 CDL00040.1 - 0.057 12.9 0.1 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase NodS PF05401.11 CDL00040.1 - 0.09 12.4 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) MTS PF05175.14 CDL00040.1 - 0.091 12.3 0.1 0.15 11.6 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_9 PF08003.11 CDL00040.1 - 0.18 10.7 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) SpoU_methylase PF00588.19 CDL00041.1 - 3e-28 98.8 0.0 3.3e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 SpoU rRNA Methylase family Moricin PF06451.11 CDL00041.1 - 0.07 12.9 0.8 4.4 7.2 0.1 2.5 1 1 1 2 2 2 0 Moricin UCR_Fe-S_N PF10399.9 CDL00042.1 - 5.7e-18 64.0 0.5 9.8e-18 63.2 0.5 1.4 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Rieske PF00355.26 CDL00042.1 - 1.3e-10 41.0 0.1 2.4e-10 40.2 0.1 1.5 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain TAT_signal PF10518.9 CDL00042.1 - 0.011 15.6 0.2 0.011 15.6 0.2 1.7 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence DUF4386 PF14329.6 CDL00042.1 - 0.04 13.8 0.1 0.055 13.3 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4386) CytB6-F_Fe-S PF08802.10 CDL00042.1 - 0.13 12.3 0.1 0.24 11.5 0.1 1.4 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit Response_reg PF00072.24 CDL00045.1 - 8.5e-22 77.5 0.1 1.4e-21 76.7 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDL00045.1 - 4e-20 71.7 0.1 9.6e-18 64.0 0.1 2.6 2 0 0 2 2 2 2 Transcriptional regulatory protein, C terminal OKR_DC_1_N PF03709.15 CDL00045.1 - 0.014 15.6 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain N6_N4_Mtase PF01555.18 CDL00045.1 - 0.19 11.4 0.0 0.45 10.2 0.0 1.5 2 0 0 2 2 2 0 DNA methylase HATPase_c PF02518.26 CDL00046.1 - 3.9e-15 56.3 0.0 6e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDL00046.1 - 1.4e-08 34.7 1.0 2e-07 30.9 0.5 3.1 3 1 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Cytochrome_CBB3 PF13442.6 CDL00047.1 - 1.8e-10 41.0 1.3 9.5e-06 25.8 0.0 2.4 2 0 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDL00047.1 - 4.6e-06 27.7 9.9 0.0048 18.0 0.5 4.0 2 2 1 3 3 3 2 Cytochrome c PSCyt3 PF07627.11 CDL00047.1 - 0.019 15.2 0.3 0.25 11.6 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1588) Ima1_N PF09779.9 CDL00047.1 - 0.032 15.1 0.3 0.11 13.3 0.1 1.8 2 0 0 2 2 2 0 Ima1 N-terminal domain Cytochrome_C7 PF14522.6 CDL00047.1 - 0.039 13.9 0.2 12 6.0 0.1 2.3 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c DUF1924 PF09086.11 CDL00047.1 - 0.14 12.5 2.6 12 6.3 0.5 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF1924) Cytochrom_NNT PF03264.14 CDL00048.1 - 8.3e-70 234.0 3.5 1e-69 233.7 3.5 1.0 1 0 0 1 1 1 1 NapC/NirT cytochrome c family, N-terminal region Cytochrom_c3_2 PF14537.6 CDL00048.1 - 2e-07 31.4 12.8 0.0006 20.2 5.5 2.2 2 0 0 2 2 2 2 Cytochrome c3 Cytochrome_C7 PF14522.6 CDL00048.1 - 5e-07 29.6 14.2 4.8e-05 23.3 3.1 2.6 2 1 1 3 3 3 3 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CDL00048.1 - 1.2e-05 25.0 14.3 0.0033 17.1 4.1 3.1 2 1 1 3 3 3 3 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrom_CIII PF02085.16 CDL00048.1 - 0.0052 17.1 18.8 0.17 12.3 2.4 2.6 1 1 1 2 2 2 1 Class III cytochrome C family Cytochrome_C554 PF13435.6 CDL00048.1 - 0.063 14.2 19.8 7.7 7.5 12.7 3.2 1 1 1 2 2 2 0 Cytochrome c554 and c-prime Kelch_5 PF13854.6 CDL00048.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Kelch motif DYW_deaminase PF14432.6 CDL00048.1 - 0.78 9.6 10.5 6.6 6.6 3.7 3.0 1 1 1 2 2 2 0 DYW family of nucleic acid deaminases MCR PF18509.1 CDL00048.1 - 1.3 8.6 16.3 3.5 7.3 0.5 4.5 4 0 0 4 4 4 0 Magnetochrome domain Cytochrome_CBB3 PF13442.6 CDL00048.1 - 1.7 9.1 16.3 15 6.0 0.1 4.2 1 1 2 4 4 4 0 Cytochrome C oxidase, cbb3-type, subunit III zinc_ribbon_15 PF17032.5 CDL00048.1 - 2.2 9.1 10.8 0.4 11.4 1.4 2.5 2 1 0 2 2 2 0 zinc-ribbon family DUF3795 PF12675.7 CDL00048.1 - 5.8 7.4 13.6 0.7 10.4 3.8 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3795) DHC PF09626.10 CDL00048.1 - 6.8 7.6 18.8 0.15 13.0 0.9 3.7 1 1 4 5 5 5 0 Dihaem cytochrome c CCP_MauG PF03150.14 CDL00048.1 - 8.6 7.0 15.3 49 4.5 0.7 4.0 1 1 2 3 3 3 0 Di-haem cytochrome c peroxidase PNP_UDP_1 PF01048.20 CDL00049.1 - 2.6e-45 154.5 0.1 3e-45 154.3 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily NAD_binding_10 PF13460.6 CDL00049.1 - 0.045 13.6 0.0 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 NAD(P)H-binding IF-2B PF01008.17 CDL00051.1 - 3.3e-57 193.9 0.0 4e-57 193.6 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family HAP2-GCS1 PF10699.9 CDL00051.1 - 0.0013 18.7 0.1 0.0024 17.8 0.1 1.4 1 0 0 1 1 1 1 Male gamete fusion factor Aldolase_II PF00596.21 CDL00052.1 - 8.1e-50 169.3 0.2 9.4e-50 169.1 0.2 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain HATPase_c PF02518.26 CDL00053.1 - 1.6e-19 70.5 0.0 3e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 CDL00053.1 - 1.4e-08 35.0 1.4 1e-07 32.2 0.1 2.7 1 1 1 2 2 2 1 HAMP domain HisKA PF00512.25 CDL00053.1 - 2.9e-08 33.6 0.2 8.6e-08 32.1 0.2 1.9 1 1 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 CDL00053.1 - 0.092 12.7 0.0 0.59 10.1 0.0 2.3 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain TMF_TATA_bd PF12325.8 CDL00053.1 - 2.2 8.5 4.8 5.7 7.2 4.8 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Response_reg PF00072.24 CDL00054.1 - 8.1e-28 96.8 0.0 1.2e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDL00054.1 - 1.7e-21 76.1 0.1 5.6e-21 74.4 0.0 1.8 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal MarR_2 PF12802.7 CDL00055.1 - 7.7e-16 57.7 0.0 1.3e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR PF01047.22 CDL00055.1 - 1.7e-08 34.2 0.0 2.9e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 CDL00055.1 - 1.7e-07 31.6 0.0 3e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.6 CDL00055.1 - 5.6e-05 22.6 0.0 0.00013 21.4 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 CDL00055.1 - 0.00026 21.0 0.0 0.00059 19.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.6 CDL00055.1 - 0.0006 19.7 1.0 0.002 18.1 0.2 2.0 1 1 1 2 2 2 1 Crp-like helix-turn-helix domain HTH_5 PF01022.20 CDL00055.1 - 0.0027 17.6 0.0 0.0044 16.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_IclR PF09339.10 CDL00055.1 - 0.0038 17.0 0.0 0.0076 16.0 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_45 PF14947.6 CDL00055.1 - 0.0083 16.1 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix TrmB PF01978.19 CDL00055.1 - 0.012 15.5 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.6 CDL00055.1 - 0.016 15.3 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain MctB PF11382.8 CDL00055.1 - 0.028 14.1 0.0 0.037 13.7 0.0 1.1 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB HxlR PF01638.17 CDL00055.1 - 0.032 14.1 0.1 0.044 13.6 0.1 1.2 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Rrf2 PF02082.20 CDL00055.1 - 0.032 14.6 0.0 0.053 13.9 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator DUF977 PF06163.11 CDL00055.1 - 0.07 13.1 0.2 0.092 12.7 0.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) TFIIE_alpha PF02002.17 CDL00055.1 - 0.089 12.7 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 TFIIE alpha subunit Aminotran_4 PF01063.19 CDL00056.1 - 3.2e-51 174.3 0.0 3.7e-51 174.1 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV MCPsignal PF00015.21 CDL00057.1 - 5e-34 117.6 46.2 1.9e-32 112.4 23.5 2.8 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDL00057.1 - 3.2e-09 37.0 0.1 3.2e-09 37.0 0.1 3.8 5 0 0 5 5 2 1 HAMP domain TACC_C PF05010.14 CDL00057.1 - 0.00058 19.7 11.9 0.04 13.7 0.4 2.4 2 0 0 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF1664 PF07889.12 CDL00057.1 - 0.0011 19.0 17.3 0.08 13.0 1.0 3.9 2 2 2 4 4 4 3 Protein of unknown function (DUF1664) Piezo_RRas_bdg PF12166.8 CDL00057.1 - 0.0073 15.6 4.3 0.047 13.0 0.1 2.2 2 0 0 2 2 2 1 Piezo non-specific cation channel, R-Ras-binding domain Sensor PF13796.6 CDL00057.1 - 0.056 13.5 1.3 1.7 8.7 0.3 2.5 2 0 0 2 2 2 0 Putative sensor DUF948 PF06103.11 CDL00057.1 - 0.073 13.3 30.7 0.37 11.1 2.5 5.1 2 1 3 5 5 5 0 Bacterial protein of unknown function (DUF948) V_ATPase_I PF01496.19 CDL00057.1 - 0.09 10.7 11.0 0.14 10.0 11.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.12 CDL00057.1 - 0.1 12.6 27.5 0.4 10.7 2.5 4.3 1 1 5 6 6 6 0 Laminin Domain II BLOC1_2 PF10046.9 CDL00057.1 - 0.15 12.4 14.1 9.3 6.6 1.1 4.6 2 2 3 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMPIT PF07851.13 CDL00057.1 - 0.69 9.1 6.8 2.5 7.2 1.5 2.5 2 0 0 2 2 2 0 TMPIT-like protein Prominin PF05478.11 CDL00057.1 - 0.9 7.4 13.4 2.5 5.9 3.6 2.9 1 1 1 3 3 3 0 Prominin UPF0449 PF15136.6 CDL00057.1 - 1.4 9.4 6.1 12 6.5 0.2 2.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Sec34 PF04136.15 CDL00057.1 - 1.5 8.7 7.4 3.6 7.5 0.5 2.8 2 1 1 3 3 3 0 Sec34-like family SKA1 PF07160.12 CDL00057.1 - 1.5 8.6 10.3 2.4 8.0 0.7 2.4 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Fib_alpha PF08702.10 CDL00057.1 - 2.3 8.4 11.4 4.1 7.6 2.4 2.9 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family KASH_CCD PF14662.6 CDL00057.1 - 3 7.6 11.4 3.2 7.5 0.7 2.9 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH GldM_N PF12081.8 CDL00057.1 - 4.3 7.4 14.1 13 5.9 0.6 2.8 1 1 0 2 2 2 0 GldM N-terminal domain FlaC_arch PF05377.11 CDL00057.1 - 7.4 7.1 16.3 11 6.5 0.5 5.5 6 1 0 6 6 6 0 Flagella accessory protein C (FlaC) PepSY_2 PF13670.6 CDL00058.1 - 0.14 12.2 1.6 0.38 10.8 0.4 2.2 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain BPL_LplA_LipB PF03099.19 CDL00059.1 - 4.3e-09 36.4 0.0 5.9e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family PGI PF00342.19 CDL00060.1 - 2.4e-221 735.5 0.0 2.8e-221 735.3 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Phage_TAC_11 PF11836.8 CDL00060.1 - 0.063 13.4 0.4 3.2 7.9 0.2 2.7 2 0 0 2 2 2 0 Phage tail tube protein, GTA-gp10 DUF4198 PF10670.9 CDL00061.1 - 2.4e-50 171.8 0.3 3e-50 171.5 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4198) CarboxypepD_reg PF13620.6 CDL00061.1 - 0.18 12.1 0.0 3.1 8.1 0.0 2.6 3 0 0 3 3 3 0 Carboxypeptidase regulatory-like domain CbiM PF01891.16 CDL00062.1 - 4.2e-46 157.4 31.1 4.7e-46 157.2 31.1 1.0 1 0 0 1 1 1 1 Cobalt uptake substrate-specific transmembrane region EMP24_GP25L PF01105.24 CDL00063.1 - 0.00072 19.5 0.0 0.001 19.1 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD CarboxypepD_reg PF13620.6 CDL00063.1 - 0.024 14.9 0.1 0.05 13.9 0.1 1.5 1 1 1 2 2 2 0 Carboxypeptidase regulatory-like domain Chitin_bind_4 PF00379.23 CDL00063.1 - 0.2 12.2 0.1 1 10.0 0.0 2.2 3 0 0 3 3 3 0 Insect cuticle protein CbiQ PF02361.16 CDL00064.1 - 1.5e-26 93.3 9.5 2.1e-26 92.9 9.5 1.1 1 0 0 1 1 1 1 Cobalt transport protein ABC_tran PF00005.27 CDL00065.1 - 1.2e-30 106.8 0.0 1.5e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDL00065.1 - 3.2e-11 43.6 0.0 2.8e-05 24.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDL00065.1 - 1.9e-07 30.8 0.1 1.7e-05 24.4 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDL00065.1 - 0.00011 21.9 0.2 0.00019 21.1 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 CDL00065.1 - 0.00027 21.1 0.1 0.0048 17.1 0.1 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit DUF3584 PF12128.8 CDL00065.1 - 0.0022 15.6 0.0 0.003 15.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_33 PF13671.6 CDL00065.1 - 0.0037 17.4 0.4 0.11 12.7 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_23 PF13476.6 CDL00065.1 - 0.0039 17.7 0.0 0.0041 17.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDL00065.1 - 0.0087 16.5 0.9 0.013 15.9 0.9 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 CDL00065.1 - 0.014 15.1 0.0 0.017 14.8 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 CDL00065.1 - 0.014 14.7 0.1 0.029 13.7 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family NACHT PF05729.12 CDL00065.1 - 0.022 14.6 0.0 0.054 13.4 0.0 1.7 2 0 0 2 2 2 0 NACHT domain NTPase_1 PF03266.15 CDL00065.1 - 0.028 14.3 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 NTPase IstB_IS21 PF01695.17 CDL00065.1 - 0.053 13.2 0.1 1.6 8.4 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein MobB PF03205.14 CDL00065.1 - 0.066 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.6 CDL00065.1 - 0.074 12.6 1.8 0.097 12.2 0.3 2.0 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CDL00065.1 - 0.088 13.1 0.5 0.48 10.7 0.5 2.0 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CDL00065.1 - 0.1 11.9 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Glyco_trans_1_4 PF13692.6 CDL00067.1 - 1.9e-19 70.4 0.0 4e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDL00067.1 - 1.3e-18 67.5 0.6 3.9e-18 66.0 0.6 1.8 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 CDL00067.1 - 3.6e-18 65.7 0.0 9.3e-18 64.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDL00067.1 - 1.6e-07 31.9 5.0 1.6e-07 31.9 5.0 2.6 2 2 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 CDL00067.1 - 0.023 15.1 0.0 0.059 13.8 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 CDL00067.1 - 0.15 12.1 0.0 1.3 9.1 0.0 2.2 1 1 0 1 1 1 0 Glycosyl transferase 4-like Metallophos_2 PF12850.7 CDL00068.1 - 2.4e-12 47.3 1.2 3.2e-11 43.7 1.2 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CDL00068.1 - 1.8e-10 41.6 5.1 2.9e-10 41.0 5.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DAGK_cat PF00781.24 CDL00069.1 - 1e-28 99.4 0.5 1.6e-28 98.8 0.5 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 CDL00069.1 - 2e-05 24.0 0.2 2.8e-05 23.5 0.2 1.3 1 0 0 1 1 1 1 ATP-NAD kinase Fe-ADH_2 PF13685.6 CDL00069.1 - 0.0044 16.8 1.2 0.013 15.2 0.4 2.0 3 0 0 3 3 3 1 Iron-containing alcohol dehydrogenase Adenine_deam_C PF13382.6 CDL00069.1 - 0.0049 16.2 1.0 0.0077 15.6 1.0 1.3 1 0 0 1 1 1 1 Adenine deaminase C-terminal domain MoCF_biosynth PF00994.24 CDL00069.1 - 0.024 14.3 0.2 0.18 11.5 0.2 2.3 1 1 0 1 1 1 0 Probable molybdopterin binding domain CorA PF01544.18 CDL00070.1 - 1.6e-69 234.4 0.0 1.9e-69 234.2 0.0 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Sm_multidrug_ex PF06695.11 CDL00070.1 - 0.057 14.1 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 Putative small multi-drug export protein FixQ PF05545.11 CDL00070.1 - 0.29 11.1 3.0 2.4 8.2 0.8 2.5 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ GTA_holin_3TM PF11351.8 CDL00070.1 - 1.7 9.2 6.0 0.63 10.6 1.4 2.4 3 0 0 3 3 3 0 Holin of 3TMs, for gene-transfer release DJ-1_PfpI PF01965.24 CDL00072.1 - 6.6e-50 169.1 0.1 7.7e-50 168.9 0.1 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 CDL00072.1 - 0.0037 17.0 0.0 0.0095 15.6 0.0 1.9 1 1 1 2 2 2 1 ThiJ/PfpI family-like Catalase_C PF18011.1 CDL00072.1 - 0.0052 16.4 0.1 0.012 15.2 0.1 1.5 1 1 0 1 1 1 1 C-terminal domain found in long catalases Peptidase_C26 PF07722.13 CDL00072.1 - 0.0096 15.7 0.0 0.02 14.7 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 CDL00072.1 - 0.011 15.5 0.0 0.02 14.7 0.0 1.4 1 1 0 1 1 1 0 Glutamine amidotransferase class-I GATase_3 PF07685.14 CDL00072.1 - 0.068 12.8 0.0 0.097 12.3 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain RHH_4 PF13467.6 CDL00073.1 - 1.9e-22 78.9 0.0 2.3e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Ribbon-helix-helix domain Thr_synth_N PF14821.6 CDL00073.1 - 0.0098 16.1 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 1 Threonine synthase N terminus GMP_synt_C PF00958.22 CDL00075.1 - 1.6e-42 143.5 0.0 2.9e-42 142.6 0.0 1.4 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 CDL00075.1 - 1.7e-39 135.6 0.0 2.4e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 CDL00075.1 - 8.5e-11 41.4 0.2 1.3e-06 27.8 0.1 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 CDL00075.1 - 6.1e-08 32.7 0.1 3e-07 30.4 0.1 2.1 1 1 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 CDL00075.1 - 2.4e-05 23.3 0.3 0.00011 21.1 0.2 1.9 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 CDL00075.1 - 0.00092 18.8 0.0 0.29 10.6 0.0 2.3 2 0 0 2 2 2 2 Queuosine biosynthesis protein QueC ATP_bind_3 PF01171.20 CDL00075.1 - 0.00099 18.9 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 PP-loop family Asn_synthase PF00733.21 CDL00075.1 - 0.0012 18.6 0.1 0.0021 17.8 0.1 1.3 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 CDL00075.1 - 0.042 13.4 0.1 0.16 11.5 0.1 1.9 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) ATP-grasp PF02222.22 CDL00076.1 - 6.2e-56 188.6 0.0 9.1e-56 188.1 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CDL00076.1 - 9.2e-08 31.9 0.0 2.1e-07 30.7 0.0 1.5 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.17 CDL00076.1 - 7.2e-07 28.9 0.0 1.5e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.14 CDL00076.1 - 6e-05 23.1 0.0 0.0001 22.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain LAL_C2 PF18603.1 CDL00076.1 - 0.033 14.3 0.4 0.16 12.2 0.4 2.2 1 0 0 1 1 1 0 L-amino acid ligase C-terminal domain 2 2-Hacid_dh_C PF02826.19 CDL00076.1 - 0.049 13.0 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPK_catalytic PF04263.16 CDL00076.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain ArsC PF03960.15 CDL00077.1 - 6.4e-16 58.1 0.0 6.4e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 ArsC family Plus-3 PF03126.18 CDL00077.1 - 0.073 13.6 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 Plus-3 domain BES1_N PF05687.13 CDL00077.1 - 0.2 12.0 0.0 0.24 11.8 0.0 1.1 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal cNMP_binding PF00027.29 CDL00078.1 - 8.2e-21 73.9 0.1 1e-20 73.6 0.1 1.1 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF3842 PF12953.7 CDL00078.1 - 0.092 13.1 0.1 0.11 12.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) Metalloenzyme PF01676.18 CDL00079.1 - 8.8e-79 264.4 0.0 1e-78 264.2 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 CDL00079.1 - 7.7e-71 238.0 0.0 1.1e-70 237.5 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.22 CDL00079.1 - 0.0042 16.7 0.0 0.0062 16.2 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Methyltransf_31 PF13847.6 CDL00079.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_M23 PF01551.22 CDL00080.1 - 2.7e-23 82.0 0.1 5.3e-23 81.0 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M23 THRAP3_BCLAF1 PF15440.6 CDL00080.1 - 0.015 14.3 7.7 0.025 13.6 7.7 1.3 1 0 0 1 1 1 0 THRAP3/BCLAF1 family Fib_alpha PF08702.10 CDL00080.1 - 0.77 9.9 7.4 5.2 7.2 0.2 2.9 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 CDL00080.1 - 0.99 9.9 5.6 78 3.8 0.1 3.8 2 2 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 CDL00080.1 - 1.7 8.7 6.5 1.3 9.1 0.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) LapA_dom PF06305.11 CDL00080.1 - 4.7 7.1 5.6 1.1 9.2 0.2 2.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Med3 PF11593.8 CDL00080.1 - 9.2 5.3 12.7 15 4.6 12.7 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Peptidase_S41 PF03572.18 CDL00081.1 - 2.1e-57 193.3 0.2 2.9e-57 192.8 0.2 1.2 1 0 0 1 1 1 1 Peptidase family S41 PDZ_6 PF17820.1 CDL00081.1 - 1.5e-13 50.4 0.0 3.9e-13 49.0 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDL00081.1 - 2.2e-12 47.1 0.0 5.7e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDL00081.1 - 3.1e-07 30.6 0.0 6.7e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain TSP_NTD PF17804.1 CDL00081.1 - 0.0037 17.5 0.0 0.0066 16.7 0.0 1.4 1 0 0 1 1 1 1 Tail specific protease N-terminal domain DUF4179 PF13786.6 CDL00081.1 - 0.083 13.4 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) Polysacc_deac_2 PF04748.13 CDL00082.1 - 4e-39 134.0 0.0 5.1e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Divergent polysaccharide deacetylase NUDIX PF00293.28 CDL00083.1 - 2.2e-27 95.7 0.1 2.6e-27 95.4 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain Aminotran_5 PF00266.19 CDL00086.1 - 6.2e-11 41.9 0.0 9e-11 41.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CDL00086.1 - 0.028 13.7 0.1 0.041 13.2 0.1 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase GDC-P PF02347.16 CDL00087.1 - 4.4e-124 414.6 0.0 5.1e-124 414.4 0.0 1.0 1 0 0 1 1 1 1 Glycine cleavage system P-protein Aminotran_5 PF00266.19 CDL00087.1 - 6.2e-08 32.0 0.0 8.2e-08 31.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CDL00087.1 - 0.00011 20.8 0.1 0.0011 17.6 0.0 2.0 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme SLH PF00395.20 CDL00087.1 - 0.051 13.6 0.0 0.36 10.9 0.0 2.3 2 0 0 2 2 2 0 S-layer homology domain GCV_H PF01597.19 CDL00088.1 - 1.9e-40 137.5 0.1 2.3e-40 137.3 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 CDL00088.1 - 0.0027 17.5 1.7 0.0027 17.5 0.3 1.8 2 0 0 2 2 2 1 Biotin-requiring enzyme RnfC_N PF13375.6 CDL00088.1 - 0.065 13.2 0.3 0.093 12.7 0.3 1.3 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain GCV_T PF01571.21 CDL00089.1 - 1.8e-83 279.9 0.0 2.1e-83 279.6 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CDL00089.1 - 1.5e-14 53.6 0.2 3.3e-14 52.6 0.2 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain LYTB PF02401.18 CDL00091.1 - 4.4e-87 291.7 0.0 5.1e-87 291.5 0.0 1.0 1 0 0 1 1 1 1 LytB protein Acetyltransf_1 PF00583.25 CDL00092.1 - 6.6e-14 52.1 0.0 8e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDL00092.1 - 4.9e-09 36.2 0.0 6.5e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDL00092.1 - 9.3e-09 35.6 0.0 1.5e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDL00092.1 - 0.0001 22.2 0.0 0.0002 21.3 0.0 1.5 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 CDL00092.1 - 0.00041 20.5 0.0 0.00055 20.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDL00092.1 - 0.002 18.2 0.0 0.0028 17.8 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CDL00092.1 - 0.0022 18.1 0.0 0.0031 17.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 CDL00092.1 - 0.09 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_3 PF13302.7 CDL00092.1 - 0.11 13.1 0.0 0.18 12.5 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain APH PF01636.23 CDL00093.1 - 1.8e-37 129.6 0.0 2.3e-37 129.2 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDL00093.1 - 0.00043 19.9 0.0 0.00074 19.2 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 CDL00093.1 - 0.17 11.2 0.1 3.5 6.9 0.0 2.6 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family EcKinase PF02958.20 CDL00093.1 - 0.22 10.8 0.1 0.39 10.0 0.1 1.4 1 1 0 1 1 1 0 Ecdysteroid kinase RNase_H PF00075.24 CDL00094.1 - 4.5e-52 176.0 0.0 5e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 CDL00094.1 - 0.029 14.2 0.0 0.071 12.9 0.0 1.6 2 0 0 2 2 2 0 Reverse transcriptase-like Putative_PNPOx PF01243.20 CDL00095.1 - 2.8e-12 46.7 0.0 4e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Hemerythrin PF01814.23 CDL00096.1 - 1.9e-09 38.3 7.0 2.2e-09 38.0 7.0 1.0 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Formyl_trans_N PF00551.19 CDL00097.1 - 9.4e-43 146.0 0.0 1.1e-42 145.8 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 CDL00097.1 - 4.2e-27 94.3 0.0 7e-27 93.6 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Pep_deformylase PF01327.21 CDL00098.1 - 9.2e-51 171.6 0.0 1e-50 171.4 0.0 1.0 1 0 0 1 1 1 1 Polypeptide deformylase MCPsignal PF00015.21 CDL00099.1 - 3.6e-32 111.6 43.5 5.1e-30 104.5 28.5 2.6 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDL00099.1 - 3.7e-11 43.2 6.0 1.4e-10 41.4 0.1 4.5 4 1 0 4 4 4 1 HAMP domain DUF3450 PF11932.8 CDL00099.1 - 0.0056 16.0 2.6 0.0056 16.0 2.6 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF3450) DUF1664 PF07889.12 CDL00099.1 - 0.0085 16.1 15.2 1.3 9.1 0.6 4.5 3 2 2 5 5 5 4 Protein of unknown function (DUF1664) DUF948 PF06103.11 CDL00099.1 - 0.032 14.5 31.4 1.6 9.0 1.3 6.8 4 1 2 7 7 7 0 Bacterial protein of unknown function (DUF948) DUF4795 PF16043.5 CDL00099.1 - 0.096 12.3 0.2 0.096 12.3 0.2 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) FLgD_tudor PF13861.6 CDL00099.1 - 0.1 12.8 0.5 0.6 10.4 0.0 2.6 2 1 0 2 2 2 0 FlgD Tudor-like domain Abi_C PF14355.6 CDL00099.1 - 0.13 12.4 2.1 16 5.7 0.1 3.4 2 1 1 3 3 3 0 Abortive infection C-terminus KIP1 PF07765.12 CDL00099.1 - 0.16 12.1 0.1 34 4.6 0.0 3.6 4 0 0 4 4 4 0 KIP1-like protein CheZ PF04344.13 CDL00099.1 - 3.9 7.3 17.3 1.1 9.1 6.0 4.0 2 1 1 4 4 4 0 Chemotaxis phosphatase, CheZ DrsE_2 PF13686.6 CDL00100.1 - 2.1e-14 53.7 0.7 5.5e-07 29.6 0.0 2.0 1 1 1 2 2 2 2 DsrE/DsrF/DrsH-like family DrsE PF02635.15 CDL00100.1 - 5.7e-08 33.1 0.1 7.8e-08 32.7 0.1 1.2 1 0 0 1 1 1 1 DsrE/DsrF-like family ThiF PF00899.21 CDL00101.1 - 1.1e-61 208.3 0.0 1.4e-61 207.9 0.0 1.0 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 CDL00101.1 - 0.00031 21.0 1.7 0.0012 19.1 1.7 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain PglD_N PF17836.1 CDL00101.1 - 0.0013 19.3 0.9 0.0036 17.9 0.4 2.0 1 1 1 2 2 2 1 PglD N-terminal domain Shikimate_DH PF01488.20 CDL00101.1 - 0.003 17.6 0.1 0.0048 17.0 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 CDL00101.1 - 0.087 13.1 0.9 0.2 11.9 0.9 1.7 1 1 0 1 1 1 0 TrkA-N domain PALP PF00291.25 CDL00102.1 - 2.1e-68 230.9 4.1 2.4e-68 230.7 4.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF3798 PF12683.7 CDL00102.1 - 0.0054 16.2 0.0 0.0082 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3798) Rrf2 PF02082.20 CDL00103.1 - 4.2e-23 81.5 0.1 5.8e-23 81.1 0.1 1.2 1 0 0 1 1 1 1 Transcriptional regulator MarR_2 PF12802.7 CDL00103.1 - 0.0003 20.6 0.6 0.0053 16.6 0.1 2.4 2 0 0 2 2 2 1 MarR family HrcA_DNA-bdg PF03444.15 CDL00103.1 - 0.00081 19.0 0.1 0.0012 18.4 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HTH_20 PF12840.7 CDL00103.1 - 0.037 14.1 0.1 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain AbiEi_4 PF13338.6 CDL00103.1 - 0.062 13.5 0.2 0.062 13.5 0.2 1.8 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin TrmB PF01978.19 CDL00103.1 - 0.086 12.7 0.1 0.17 11.8 0.0 1.5 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Linker_histone PF00538.19 CDL00103.1 - 0.13 12.6 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 linker histone H1 and H5 family PanZ PF12568.8 CDL00103.1 - 0.15 11.7 0.5 0.28 10.9 0.5 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ dUTPase PF00692.19 CDL00104.1 - 1.7e-29 102.1 0.0 1.9e-29 101.9 0.0 1.0 1 0 0 1 1 1 1 dUTPase DFP PF04127.15 CDL00105.1 - 1e-66 224.3 0.0 6.6e-66 221.7 0.0 2.0 2 0 0 2 2 2 1 DNA / pantothenate metabolism flavoprotein Flavoprotein PF02441.19 CDL00105.1 - 6.5e-45 152.7 0.0 1.1e-44 151.9 0.0 1.4 1 0 0 1 1 1 1 Flavoprotein Glyco_trans_4_4 PF13579.6 CDL00105.1 - 0.00074 20.0 2.6 0.14 12.6 0.6 3.1 3 1 0 3 3 3 2 Glycosyl transferase 4-like domain YjeF_N PF03853.15 CDL00105.1 - 0.014 15.3 0.0 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 YjeF-related protein N-terminus ABC1 PF03109.16 CDL00106.1 - 8.3e-35 119.5 0.2 1.4e-34 118.8 0.2 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 CDL00106.1 - 0.0056 16.1 0.0 0.011 15.1 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 CDL00106.1 - 0.016 14.8 0.0 0.061 12.9 0.0 1.9 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 CDL00106.1 - 0.044 13.7 10.0 7 6.5 10.0 3.2 1 1 0 1 1 1 0 Phosphotransferase enzyme family Ubie_methyltran PF01209.18 CDL00107.1 - 1.1e-80 270.3 0.0 1.4e-80 270.0 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 CDL00107.1 - 1.8e-21 76.5 0.0 4.6e-21 75.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL00107.1 - 1.1e-19 70.9 0.0 3e-19 69.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00107.1 - 1.1e-09 38.9 0.0 1.9e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00107.1 - 1.3e-09 38.0 0.0 1.7e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL00107.1 - 8.3e-08 32.2 0.0 1.2e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 CDL00107.1 - 3.3e-05 23.8 0.0 0.0001 22.3 0.0 1.9 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 CDL00107.1 - 0.0054 16.3 0.0 0.036 13.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CDL00107.1 - 0.13 11.6 0.0 0.25 10.6 0.0 1.5 1 1 0 1 1 1 0 O-methyltransferase domain Fapy_DNA_glyco PF01149.24 CDL00108.1 - 4e-33 114.5 0.0 6.3e-33 113.8 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 CDL00108.1 - 6.7e-27 93.3 0.0 1.1e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain zf-FPG_IleRS PF06827.14 CDL00108.1 - 0.022 14.6 1.9 0.023 14.6 0.0 1.9 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS ECH_1 PF00378.20 CDL00110.1 - 1.6e-88 296.2 1.2 1.8e-88 296.1 1.2 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDL00110.1 - 6.6e-39 134.3 4.2 5.4e-38 131.3 4.4 1.8 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase HhH-GPD PF00730.25 CDL00111.1 - 1e-15 58.1 0.0 1.3e-15 57.8 0.0 1.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CDL00111.1 - 4.7e-07 29.3 0.0 1.1e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 CDL00111.1 - 0.0022 18.3 9.6 0.0043 17.4 9.6 1.5 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III DUF1848 PF08902.11 CDL00112.1 - 1.5e-80 270.8 0.0 1.7e-80 270.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1848) HSP70 PF00012.20 CDL00113.1 - 2.7e-276 917.6 9.7 3e-276 917.4 9.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDL00113.1 - 5.6e-17 61.6 5.9 1.2e-15 57.2 0.5 2.7 3 1 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.6 CDL00113.1 - 0.0011 19.4 4.7 0.23 11.9 0.0 3.8 3 1 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.16 CDL00113.1 - 0.0096 15.7 0.0 0.028 14.1 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DMRL_synthase PF00885.19 CDL00113.1 - 0.083 12.7 0.5 0.35 10.7 0.1 2.2 2 0 0 2 2 2 0 6,7-dimethyl-8-ribityllumazine synthase DnaJ_C PF01556.18 CDL00114.1 - 2.1e-39 134.9 0.0 2.7e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDL00114.1 - 4.8e-27 93.9 3.8 4.8e-27 93.9 3.8 2.1 2 0 0 2 2 2 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CDL00114.1 - 5.9e-13 49.0 18.5 1e-12 48.2 18.5 1.4 1 0 0 1 1 1 1 DnaJ central domain LTXXQ PF07813.12 CDL00114.1 - 0.00031 21.4 0.3 0.28 11.9 0.0 2.3 2 0 0 2 2 2 2 LTXXQ motif family protein UvsW PF11637.8 CDL00114.1 - 0.083 13.0 0.0 0.33 11.1 0.0 2.0 2 0 0 2 2 2 0 ATP-dependant DNA helicase UvsW Anti-TRAP PF15777.5 CDL00114.1 - 0.11 12.4 19.4 1.3 9.0 3.7 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CDL00114.1 - 2.2 8.4 8.6 1.5e+02 2.4 8.6 2.3 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CcdA PF07362.12 CDL00115.1 - 3.3e-30 104.3 1.2 3.6e-30 104.2 1.2 1.0 1 0 0 1 1 1 1 Post-segregation antitoxin CcdA CcdB PF01845.17 CDL00116.1 - 7e-31 106.4 0.0 7.7e-31 106.3 0.0 1.0 1 0 0 1 1 1 1 CcdB protein DapB_C PF05173.14 CDL00117.1 - 1.6e-44 150.8 0.0 2.6e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, C-terminus DapB_N PF01113.20 CDL00117.1 - 8.2e-36 122.9 0.3 1.3e-35 122.2 0.3 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus GSDH PF07995.11 CDL00118.1 - 1.2e-12 47.8 0.1 1.6e-10 40.9 0.0 3.0 2 1 0 2 2 2 1 Glucose / Sorbosone dehydrogenase NHL PF01436.21 CDL00118.1 - 4.3e-05 23.3 0.3 0.2 11.7 0.2 3.8 3 0 0 3 3 3 2 NHL repeat GrpE PF01025.19 CDL00119.1 - 1.4e-50 171.2 0.4 1.7e-50 171.0 0.4 1.0 1 0 0 1 1 1 1 GrpE FlaC_arch PF05377.11 CDL00119.1 - 0.097 13.1 0.2 0.22 11.9 0.2 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF1192 PF06698.11 CDL00119.1 - 0.22 11.6 2.4 0.57 10.3 2.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) HrcA PF01628.21 CDL00120.1 - 5.4e-55 186.7 0.0 6.9e-55 186.3 0.0 1.1 1 0 0 1 1 1 1 HrcA protein C terminal domain HTH_11 PF08279.12 CDL00120.1 - 0.0013 18.6 0.0 0.0029 17.5 0.0 1.5 1 0 0 1 1 1 1 HTH domain HrcA_DNA-bdg PF03444.15 CDL00120.1 - 0.0048 16.5 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding GntR PF00392.21 CDL00120.1 - 0.0059 16.2 0.1 0.017 14.8 0.1 1.8 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family LexA_DNA_bind PF01726.16 CDL00120.1 - 0.053 13.3 0.0 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 LexA DNA binding domain DUF2111 PF09884.9 CDL00120.1 - 0.064 13.3 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2111) KfrA_N PF11740.8 CDL00120.1 - 0.61 10.8 2.8 19 6.0 0.3 2.5 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term RNase_PH PF01138.21 CDL00121.1 - 1.8e-22 80.2 0.0 3.5e-22 79.3 0.0 1.4 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDL00121.1 - 2.6e-10 40.2 0.0 4.6e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Ham1p_like PF01725.16 CDL00122.1 - 6.9e-60 202.2 0.0 7.7e-60 202.0 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Radical_SAM PF04055.21 CDL00123.1 - 2.9e-18 66.8 0.0 4.5e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily HemN_C PF06969.16 CDL00123.1 - 2.9e-13 49.7 1.1 6.1e-13 48.6 0.6 1.9 2 0 0 2 2 2 1 HemN C-terminal domain Fer4_14 PF13394.6 CDL00123.1 - 0.0064 16.6 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 CDL00123.1 - 0.079 13.2 0.0 0.17 12.1 0.0 1.5 2 0 0 2 2 2 0 4Fe-4S single cluster domain Glyco_transf_9 PF01075.17 CDL00124.1 - 2.1e-24 86.2 0.0 4.9e-24 85.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) Glyco_transf_4 PF13439.6 CDL00125.1 - 3e-33 115.2 4.9 6e-31 107.7 3.8 2.4 2 1 0 2 2 2 2 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 CDL00125.1 - 7.2e-32 110.3 0.0 2e-31 108.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDL00125.1 - 1.7e-27 96.5 0.0 6.8e-27 94.5 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDL00125.1 - 4.5e-15 56.4 5.1 4.5e-15 56.4 5.1 2.7 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 CDL00125.1 - 1.2e-09 38.3 0.0 2.4e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 CDL00125.1 - 2.9e-08 34.0 0.1 1.3e-07 31.9 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Peripla_BP_4 PF13407.6 CDL00125.1 - 0.017 14.7 0.1 0.42 10.1 0.0 2.3 2 1 0 2 2 2 0 Periplasmic binding protein domain Oxidored_nitro PF00148.19 CDL00125.1 - 0.085 11.6 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase 7tm_6 PF02949.20 CDL00125.1 - 0.22 10.6 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 7tm Odorant receptor Hydrolase_4 PF12146.8 CDL00126.1 - 4.5e-15 55.6 0.0 5.1e-11 42.3 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDL00126.1 - 7.4e-13 49.6 0.6 1.1e-12 49.0 0.6 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDL00126.1 - 2.9e-10 40.2 0.1 7.8e-10 38.8 0.1 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.20 CDL00126.1 - 0.00015 21.5 0.0 0.00028 20.6 0.0 1.5 1 0 0 1 1 1 1 Putative esterase UPF0227 PF05728.12 CDL00126.1 - 0.00041 20.3 0.0 0.0018 18.3 0.0 1.9 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0227) Peptidase_S9 PF00326.21 CDL00126.1 - 0.0018 17.8 0.0 0.019 14.4 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDL00126.1 - 0.0042 16.7 0.0 0.018 14.6 0.0 1.9 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Patatin PF01734.22 CDL00126.1 - 0.069 13.3 0.0 0.098 12.8 0.0 1.3 1 0 0 1 1 1 0 Patatin-like phospholipase Methyltransf_21 PF05050.12 CDL00127.1 - 6e-15 55.7 0.0 8.3e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain NQRA PF05896.11 CDL00127.1 - 0.22 10.9 0.0 0.32 10.4 0.0 1.1 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) PC4 PF02229.16 CDL00128.1 - 0.16 11.7 0.0 0.44 10.2 0.0 1.7 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) HlyD_D23 PF16576.5 CDL00129.1 - 4.5e-23 81.6 7.2 5e-22 78.2 7.2 2.0 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 CDL00129.1 - 9.8e-22 77.7 3.0 2.7e-18 66.6 0.0 3.1 2 2 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDL00129.1 - 9.3e-15 54.2 0.2 9.3e-15 54.2 0.2 4.2 4 0 0 4 4 4 1 Biotin-lipoyl like HlyD PF00529.20 CDL00129.1 - 1.8e-07 31.0 0.4 3.8e-07 29.9 0.5 1.7 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl PF00364.22 CDL00129.1 - 0.0047 16.7 0.1 0.33 10.8 0.0 2.5 2 0 0 2 2 2 1 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 CDL00129.1 - 0.0071 16.1 0.0 0.033 13.9 0.0 2.2 2 1 0 2 2 2 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 MscS_porin PF12795.7 CDL00129.1 - 0.058 12.9 20.5 0.083 12.4 20.5 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain HlyD_2 PF12700.7 CDL00129.1 - 0.12 11.1 0.0 0.56 8.9 0.0 2.1 1 1 0 1 1 1 0 HlyD family secretion protein DUF4407 PF14362.6 CDL00129.1 - 0.33 10.3 16.0 0.081 12.3 6.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF945 PF06097.11 CDL00129.1 - 0.55 9.3 8.1 11 5.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF945) TPR_MLP1_2 PF07926.12 CDL00129.1 - 1.8 8.7 14.8 0.84 9.7 11.1 1.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 CDL00129.1 - 2.1 5.8 12.9 2.8 5.3 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MFS_1 PF07690.16 CDL00130.1 - 2.8e-48 164.7 45.4 2.8e-48 164.7 45.4 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily CbtB PF09489.10 CDL00130.1 - 0.056 13.6 0.1 0.64 10.2 0.1 2.9 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) UL42 PF17638.2 CDL00130.1 - 0.11 12.5 1.5 0.21 11.6 0.3 2.1 2 0 0 2 2 2 0 HCMV UL42 MFS_1_like PF12832.7 CDL00130.1 - 0.99 8.2 29.5 0.4 9.5 5.8 2.3 2 0 0 2 2 2 0 MFS_1 like family Sugar_tr PF00083.24 CDL00130.1 - 2.9 6.7 41.6 0.062 12.2 22.6 3.1 3 1 1 4 4 4 0 Sugar (and other) transporter Asn_synthase PF00733.21 CDL00131.1 - 7.8e-110 367.9 0.0 9.7e-110 367.6 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CDL00131.1 - 5.2e-41 139.4 0.0 8.3e-41 138.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDL00131.1 - 2.4e-37 128.1 0.0 5.7e-37 126.9 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CDL00131.1 - 0.00027 20.5 0.0 0.00049 19.6 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 CDL00131.1 - 0.0019 17.4 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 CDL00131.1 - 0.16 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC HPTransfase PF10090.9 CDL00132.1 - 1.3e-23 83.1 0.6 2.9e-23 82.0 0.2 1.7 1 1 1 2 2 2 1 Histidine phosphotransferase C-terminal domain CheW PF01584.19 CDL00133.1 - 1.2e-30 106.0 3.0 3.2e-22 78.7 0.7 2.5 2 0 0 2 2 2 2 CheW-like domain Response_reg PF00072.24 CDL00133.1 - 8e-21 74.3 0.0 1.7e-20 73.3 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Hpt PF01627.23 CDL00133.1 - 1.7e-17 63.5 0.1 2e-16 60.0 0.0 2.6 2 0 0 2 2 2 1 Hpt domain HATPase_c PF02518.26 CDL00133.1 - 8.2e-16 58.5 0.2 1.8e-15 57.4 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase H-kinase_dim PF02895.14 CDL00133.1 - 5.6e-15 55.5 2.4 1.4e-14 54.2 2.4 1.8 1 0 0 1 1 1 1 Signal transducing histidine kinase, homodimeric domain Musclin PF11037.8 CDL00133.1 - 0.092 12.7 0.0 0.27 11.2 0.0 1.8 1 0 0 1 1 1 0 Insulin-resistance promoting peptide in skeletal muscle DUF4680 PF15730.5 CDL00133.1 - 6.5 7.1 7.9 12 6.3 7.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4680) CheW PF01584.19 CDL00134.1 - 3e-27 94.9 0.2 3.7e-27 94.6 0.2 1.0 1 0 0 1 1 1 1 CheW-like domain Response_reg PF00072.24 CDL00135.1 - 5.4e-30 103.8 0.1 5.9e-30 103.7 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain CheB_methylest PF01339.17 CDL00136.1 - 8.7e-54 181.8 0.1 1.7e-53 180.8 0.1 1.5 1 0 0 1 1 1 1 CheB methylesterase Response_reg PF00072.24 CDL00136.1 - 5.7e-23 81.2 0.4 9.9e-23 80.4 0.4 1.4 1 0 0 1 1 1 1 Response regulator receiver domain CheR PF01739.18 CDL00137.1 - 4.8e-64 215.4 0.0 6.1e-64 215.1 0.0 1.1 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.15 CDL00137.1 - 4e-10 39.2 0.1 7.6e-10 38.4 0.1 1.4 1 0 0 1 1 1 1 CheR methyltransferase, all-alpha domain Methyltransf_12 PF08242.12 CDL00137.1 - 1.5e-07 32.0 0.0 4.7e-06 27.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL00137.1 - 3.4e-07 30.9 0.0 0.00012 22.7 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00137.1 - 1.3e-06 28.3 0.0 0.017 14.9 0.0 2.6 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 CDL00137.1 - 2.9e-05 24.6 0.1 0.00078 20.0 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL00137.1 - 6.3e-05 22.9 0.0 0.00012 21.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NAS PF03059.16 CDL00137.1 - 0.0037 16.6 0.0 0.0057 16.0 0.0 1.2 1 0 0 1 1 1 1 Nicotianamine synthase protein PEPCK_GTP PF00821.18 CDL00137.1 - 0.052 12.4 0.0 0.092 11.5 0.0 1.4 1 1 0 1 1 1 0 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain Epimerase PF01370.21 CDL00138.1 - 0.003 17.1 0.0 0.041 13.4 0.0 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDL00138.1 - 0.018 14.1 0.0 0.031 13.4 0.0 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain TPR_19 PF14559.6 CDL00139.1 - 9.6e-11 42.0 8.7 2e-05 25.0 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDL00139.1 - 1.1e-10 40.8 1.6 0.63 10.3 0.0 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDL00139.1 - 1.8e-10 41.3 5.9 6.8e-05 23.4 0.2 3.6 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDL00139.1 - 2.5e-09 37.1 15.6 0.00018 21.6 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDL00139.1 - 6.2e-08 32.2 3.0 0.003 17.2 0.1 4.7 5 1 0 5 5 5 2 TPR repeat TPR_17 PF13431.6 CDL00139.1 - 4.2e-07 29.9 0.7 0.0091 16.3 0.0 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDL00139.1 - 5.5e-07 29.1 0.0 0.055 13.3 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDL00139.1 - 0.00033 20.8 0.3 0.9 9.8 0.2 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 CDL00139.1 - 0.0025 18.1 9.0 0.04 14.2 0.1 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 CDL00139.1 - 0.004 16.8 0.8 0.64 9.7 0.0 2.4 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_6 PF13174.6 CDL00139.1 - 0.0047 17.5 1.4 12 6.8 0.0 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat Coatomer_E PF04733.14 CDL00139.1 - 0.012 15.1 0.5 1.5 8.2 0.1 3.0 1 1 2 3 3 3 0 Coatomer epsilon subunit TPR_14 PF13428.6 CDL00139.1 - 0.024 15.4 16.8 0.052 14.4 0.1 4.7 4 2 1 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDL00139.1 - 0.074 13.1 0.2 4.9 7.3 0.0 2.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat PhoH PF02562.16 CDL00141.1 - 8.1e-79 263.8 0.0 9.5e-79 263.6 0.0 1.1 1 0 0 1 1 1 1 PhoH-like protein AAA_30 PF13604.6 CDL00141.1 - 3e-11 43.4 0.0 5.5e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDL00141.1 - 1.1e-06 29.1 0.0 2.4e-05 24.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CDL00141.1 - 0.00063 19.5 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein UvrD-helicase PF00580.21 CDL00141.1 - 0.00092 18.8 0.1 0.33 10.4 0.0 2.1 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_25 PF13481.6 CDL00141.1 - 0.0013 18.3 0.0 0.0027 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDL00141.1 - 0.0014 18.9 0.0 0.0083 16.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CDL00141.1 - 0.0026 17.5 0.0 0.015 15.1 0.0 1.9 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 CDL00141.1 - 0.016 15.0 0.0 6 6.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CDL00141.1 - 0.12 11.6 0.1 0.35 10.1 0.1 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Zot PF05707.12 CDL00141.1 - 0.17 11.5 0.0 6.5 6.3 0.0 2.2 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) AAA PF00004.29 CDL00141.1 - 0.17 12.3 0.0 0.46 10.9 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) zf-dskA_traR PF01258.17 CDL00142.1 - 5.1e-10 39.1 6.6 5.1e-10 39.1 6.6 1.8 2 0 0 2 2 2 1 Prokaryotic dksA/traR C4-type zinc finger DZR PF12773.7 CDL00142.1 - 0.17 12.0 7.8 0.48 10.5 7.8 1.7 1 1 0 1 1 1 0 Double zinc ribbon SBP_bac_3 PF00497.20 CDL00143.1 - 6.8e-16 58.4 0.0 6.3e-15 55.2 0.0 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DEAD PF00270.29 CDL00145.1 - 0.0018 18.1 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Hemerythrin PF01814.23 CDL00147.1 - 5e-10 40.1 0.8 5.9e-10 39.9 0.8 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain PAS_3 PF08447.12 CDL00148.1 - 1.8e-14 53.8 0.0 2.7e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CDL00148.1 - 7.2e-09 35.6 0.0 1.1e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDL00148.1 - 1.8e-08 34.6 0.0 2.6e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 CDL00148.1 - 0.012 15.6 0.0 0.027 14.5 0.0 1.6 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 CDL00148.1 - 0.015 15.6 0.0 0.036 14.3 0.0 1.7 1 1 0 1 1 1 0 PAS fold MCPsignal PF00015.21 CDL00149.1 - 1.4e-37 129.2 32.4 6.8e-37 126.9 19.6 2.8 1 1 0 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain CZB PF13682.6 CDL00149.1 - 5.7e-11 42.7 0.0 1.2e-10 41.7 0.0 1.6 1 0 0 1 1 1 1 Chemoreceptor zinc-binding domain Syntaxin_2 PF14523.6 CDL00149.1 - 0.0019 18.6 2.0 1.1 9.7 0.1 3.4 3 2 0 3 3 3 2 Syntaxin-like protein DUF1664 PF07889.12 CDL00149.1 - 0.011 15.7 7.2 0.2 11.7 0.4 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 CDL00149.1 - 0.019 13.9 0.4 0.019 13.9 0.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein HAMP PF00672.25 CDL00149.1 - 0.056 13.8 0.6 0.056 13.8 0.6 3.6 3 1 0 3 3 3 0 HAMP domain BLOC1_2 PF10046.9 CDL00149.1 - 0.12 12.7 6.2 1.3 9.3 0.1 4.2 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF986 PF06173.12 CDL00149.1 - 0.14 12.2 0.2 0.25 11.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF986) Laminin_II PF06009.12 CDL00149.1 - 0.67 10.0 14.9 5.3 7.1 2.2 3.8 1 1 3 4 4 4 0 Laminin Domain II APG17 PF04108.12 CDL00149.1 - 0.83 8.7 6.1 15 4.5 0.2 3.1 1 1 2 3 3 3 0 Autophagy protein Apg17 Fib_alpha PF08702.10 CDL00149.1 - 3.6 7.8 4.2 17 5.6 0.6 2.6 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DHR10 PF18595.1 CDL00149.1 - 4.9 7.2 7.4 5.7 7.0 0.1 3.5 2 2 1 3 3 3 0 Designed helical repeat protein 10 domain Cauli_DNA-bind PF03310.13 CDL00149.1 - 7.9 6.6 5.7 1.5 8.9 0.3 2.6 3 0 0 3 3 3 0 Caulimovirus DNA-binding protein ATG16 PF08614.11 CDL00149.1 - 8 6.6 8.5 1.8 8.7 3.5 2.4 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) CheZ PF04344.13 CDL00150.1 - 7.4e-13 48.9 1.8 6.6e-09 36.0 0.0 2.4 3 0 0 3 3 3 2 Chemotaxis phosphatase, CheZ Bcl-2_3 PF15286.6 CDL00150.1 - 0.034 14.8 0.0 0.052 14.2 0.0 1.2 1 0 0 1 1 1 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like DUF3418 PF11898.8 CDL00150.1 - 0.039 12.6 0.2 0.044 12.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) DUF948 PF06103.11 CDL00150.1 - 0.083 13.2 2.5 0.84 9.9 0.2 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) SlyX PF04102.12 CDL00150.1 - 0.11 13.2 0.0 2.5 8.8 0.0 3.0 3 0 0 3 3 3 0 SlyX zf-C4H2 PF10146.9 CDL00150.1 - 0.11 12.8 0.7 0.21 11.9 0.1 1.6 2 0 0 2 2 2 0 Zinc finger-containing protein CHDCT2 PF08074.11 CDL00150.1 - 0.13 12.5 0.4 0.91 9.7 0.0 2.1 2 1 0 2 2 2 0 CHDCT2 (NUC038) domain SAMP PF05924.11 CDL00151.1 - 0.0096 15.2 0.2 0.016 14.5 0.2 1.4 1 0 0 1 1 1 1 SAMP Motif Phage_integrase PF00589.22 CDL00154.1 - 6e-10 39.2 0.0 7.1e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Phage integrase family DDE_3 PF13358.6 CDL00155.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL00155.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDL00156.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL00156.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL00156.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL00156.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL00156.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL00156.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain Xan_ur_permease PF00860.20 CDL00158.1 - 2.9e-54 184.2 45.0 2.9e-54 184.2 45.0 1.3 1 1 0 1 1 1 1 Permease family Pantoate_ligase PF02569.15 CDL00159.1 - 1.9e-96 322.4 0.0 2.2e-96 322.2 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Pantoate_transf PF02548.15 CDL00160.1 - 9.9e-106 352.9 0.9 1.1e-105 352.7 0.9 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase Cpn60_TCP1 PF00118.24 CDL00160.1 - 0.15 10.6 0.0 0.24 10.0 0.0 1.2 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family HTH_Crp_2 PF13545.6 CDL00161.1 - 3.4e-19 68.6 0.0 7e-19 67.6 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Crp PF00325.20 CDL00161.1 - 9.2e-18 63.6 0.5 2.2e-17 62.4 0.1 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, crp family cNMP_binding PF00027.29 CDL00161.1 - 1.2e-16 60.5 0.0 2.6e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_23 PF13384.6 CDL00161.1 - 0.0082 15.9 0.0 0.021 14.6 0.0 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.6 CDL00161.1 - 0.025 14.1 0.0 0.076 12.6 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 CDL00161.1 - 0.031 14.2 0.1 0.25 11.3 0.0 2.4 3 0 0 3 3 3 0 MarR family HTH_11 PF08279.12 CDL00161.1 - 0.09 12.7 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 HTH domain HTH_Tnp_ISL3 PF13542.6 CDL00161.1 - 0.093 12.2 0.0 0.24 10.9 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 MarR PF01047.22 CDL00161.1 - 0.13 12.2 0.0 0.47 10.4 0.0 1.9 2 0 0 2 2 2 0 MarR family FixS PF03597.15 CDL00162.1 - 2.6e-23 81.4 2.8 3.4e-23 81.1 2.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase maturation protein cbb3-type Promethin PF16015.5 CDL00162.1 - 0.69 9.9 2.9 0.83 9.6 2.9 1.1 1 0 0 1 1 1 0 Promethin E1-E2_ATPase PF00122.20 CDL00163.1 - 1.2e-44 152.0 3.2 1.2e-44 152.0 3.2 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CDL00163.1 - 8.5e-35 121.0 0.3 2.2e-34 119.6 0.1 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CDL00163.1 - 4.9e-08 33.3 0.0 1.6e-07 31.7 0.0 2.0 1 0 0 1 1 1 1 Heavy-metal-associated domain ATPase-cat_bd PF12156.8 CDL00163.1 - 5.8e-08 33.4 1.4 1.6e-07 32.0 1.4 1.7 1 1 0 1 1 1 1 Putative metal-binding domain of cation transport ATPase HAD PF12710.7 CDL00163.1 - 9.6e-06 26.1 0.1 0.00015 22.2 0.1 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDL00163.1 - 0.0035 17.1 0.0 0.0082 15.9 0.0 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase MarR_2 PF12802.7 CDL00163.1 - 0.06 13.2 0.1 0.26 11.2 0.1 2.1 1 0 0 1 1 1 0 MarR family FixH PF05751.11 CDL00164.1 - 6.3e-38 130.1 0.2 7.6e-38 129.9 0.2 1.0 1 0 0 1 1 1 1 FixH YtkA PF13115.6 CDL00164.1 - 0.0031 18.1 0.1 0.005 17.4 0.1 1.3 1 0 0 1 1 1 1 YtkA-like Fer4_18 PF13746.6 CDL00165.1 - 2.1e-41 140.7 7.0 5.4e-41 139.3 7.0 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain FixG_C PF11614.8 CDL00165.1 - 8.1e-27 93.8 0.1 1.1e-26 93.4 0.1 1.2 1 0 0 1 1 1 1 IG-like fold at C-terminal of FixG, putative oxidoreductase Fer4_7 PF12838.7 CDL00165.1 - 6.8e-11 42.6 3.4 2.2e-05 25.0 1.4 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDL00165.1 - 3.9e-09 36.5 5.9 8e-05 22.7 1.6 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDL00165.1 - 2.3e-08 34.3 5.0 0.00076 19.9 1.4 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_5 PF12801.7 CDL00165.1 - 3.3e-08 33.4 4.5 3.3e-08 33.4 4.5 3.7 5 0 0 5 5 4 1 4Fe-4S binding domain Fer4_17 PF13534.6 CDL00165.1 - 4.3e-07 30.4 6.7 0.00088 19.8 1.8 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 CDL00165.1 - 5.8e-06 25.9 23.5 0.00015 21.4 3.0 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_2 PF12797.7 CDL00165.1 - 8.7e-05 22.4 18.6 0.0033 17.4 2.5 2.9 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_6 PF12837.7 CDL00165.1 - 0.00013 21.9 17.2 0.027 14.5 4.2 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 CDL00165.1 - 0.00041 20.4 14.4 0.0029 17.7 13.3 2.4 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDL00165.1 - 0.00045 21.1 13.1 0.0043 18.0 2.4 2.6 1 1 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_4 PF12800.7 CDL00165.1 - 0.00065 20.0 17.9 0.022 15.2 2.0 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_13 PF13370.6 CDL00165.1 - 0.011 16.3 10.8 0.087 13.4 1.5 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_21 PF14697.6 CDL00165.1 - 0.055 13.6 19.6 0.85 9.8 3.9 2.8 1 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDL00165.1 - 0.06 14.3 24.9 0.32 12.0 4.7 3.4 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_15 PF13459.6 CDL00165.1 - 0.23 12.2 12.1 1.5 9.7 2.5 2.5 1 1 1 2 2 2 0 4Fe-4S single cluster domain Fer4_20 PF14691.6 CDL00165.1 - 2 8.2 5.9 5.7 6.7 5.9 1.7 1 1 0 1 1 1 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_22 PF17179.4 CDL00165.1 - 8.8 7.3 15.6 8.8 7.3 3.8 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain FixP_N PF14715.6 CDL00166.1 - 6.7e-24 83.4 8.3 6.7e-24 83.4 8.3 1.7 2 0 0 2 2 2 1 N-terminal domain of cytochrome oxidase-cbb3, FixP Cytochrome_CBB3 PF13442.6 CDL00166.1 - 3e-21 75.5 2.5 3e-10 40.3 0.1 2.7 3 0 0 3 3 3 2 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDL00166.1 - 5.8e-17 62.6 0.1 5.4e-07 30.7 0.0 2.7 2 0 0 2 2 2 2 Cytochrome c Cytochrom_C550 PF14495.6 CDL00166.1 - 0.00041 20.1 0.5 1.1 9.0 0.0 2.5 2 1 0 2 2 2 2 Cytochrome c-550 domain Paired_CXXCH_1 PF09699.10 CDL00166.1 - 0.022 14.5 0.4 4.4 7.1 0.0 2.3 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_C7 PF14522.6 CDL00166.1 - 0.038 14.0 0.0 8.7 6.4 0.0 2.4 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c GSu_C4xC__C2xCH PF09698.10 CDL00166.1 - 0.053 14.3 0.9 7.6 7.4 0.2 3.1 2 0 0 2 2 2 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) DnaJ_CXXCXGXG PF00684.19 CDL00166.1 - 0.064 13.6 1.1 9.7 6.6 0.3 2.3 2 0 0 2 2 2 0 DnaJ central domain FixQ PF05545.11 CDL00167.1 - 3.9e-20 71.6 0.1 4.3e-20 71.4 0.1 1.0 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ DUF2523 PF10734.9 CDL00167.1 - 0.1 13.2 0.5 0.12 12.9 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2523) FixO PF02433.15 CDL00168.1 - 1.2e-92 309.3 0.0 1.4e-92 309.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C oxidase, mono-heme subunit/FixO Cytochrom_C PF00034.21 CDL00168.1 - 4.1e-05 24.6 0.2 0.0029 18.7 0.0 2.3 1 1 0 2 2 2 1 Cytochrome c DUF3930 PF13067.6 CDL00168.1 - 0.096 12.9 0.0 0.3 11.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3930) COX1 PF00115.20 CDL00169.1 - 3.2e-119 398.6 63.8 3.2e-119 398.6 63.8 1.2 1 1 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Methyltrans_SAM PF10672.9 CDL00170.1 - 1.3e-19 70.5 0.0 1.7e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase PUA_3 PF17785.1 CDL00170.1 - 1.4e-18 66.4 0.0 3.2e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 PUA-like domain Methyltransf_31 PF13847.6 CDL00170.1 - 4.5e-06 26.5 0.0 7.5e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDL00170.1 - 5.3e-06 26.2 0.0 8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 CDL00170.1 - 3.7e-05 23.3 0.0 6.2e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_15 PF09445.10 CDL00170.1 - 0.00013 21.6 0.0 0.00019 21.1 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 CDL00170.1 - 0.00028 21.5 0.1 0.001 19.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 CDL00170.1 - 0.0027 17.1 0.2 0.004 16.6 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 CDL00170.1 - 0.009 15.7 0.0 0.055 13.1 0.0 2.3 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_24 PF13578.6 CDL00170.1 - 0.011 16.7 0.1 0.078 14.0 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain ADH_zinc_N PF00107.26 CDL00170.1 - 0.09 12.8 0.3 0.17 11.9 0.3 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase FIST_C PF10442.9 CDL00173.1 - 1.3e-14 54.3 0.2 2.9e-14 53.1 0.1 1.7 2 0 0 2 2 2 1 FIST C domain FIST PF08495.10 CDL00173.1 - 4.3e-13 49.6 0.0 1.1e-10 41.9 0.0 2.3 2 0 0 2 2 2 2 FIST N domain HATPase_c PF02518.26 CDL00174.1 - 2e-17 63.7 0.0 4e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDL00174.1 - 0.00018 21.4 3.0 0.00042 20.3 0.0 2.5 2 1 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Speriolin_N PF15058.6 CDL00174.1 - 0.0084 16.2 1.5 0.014 15.5 1.5 1.3 1 0 0 1 1 1 1 Speriolin N terminus Poxvirus_B22R_C PF13168.6 CDL00174.1 - 0.05 13.1 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal Arm-DNA-bind_5 PF17293.2 CDL00174.1 - 0.29 11.6 2.4 0.64 10.5 2.4 1.5 1 0 0 1 1 1 0 Arm DNA-binding domain Fzo_mitofusin PF04799.13 CDL00174.1 - 0.52 9.8 2.6 0.94 9.0 2.6 1.3 1 0 0 1 1 1 0 fzo-like conserved region DUF1987 PF09345.10 CDL00175.1 - 8.4e-43 144.9 0.1 9.3e-43 144.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1987) HATPase_c PF02518.26 CDL00177.1 - 2.4e-25 89.2 0.0 5.8e-25 88.0 0.0 1.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDL00177.1 - 1.1e-08 34.9 2.0 1.7e-08 34.4 0.2 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 CDL00177.1 - 2.6e-06 27.6 0.0 6.4e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c_2 PF13581.6 CDL00177.1 - 6e-06 26.2 0.0 1.7e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 CDL00177.1 - 0.019 14.9 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 GHKL domain SLATT_1 PF18181.1 CDL00177.1 - 0.024 14.6 1.7 0.052 13.5 1.7 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 YscO PF07321.12 CDL00177.1 - 0.042 13.8 7.4 0.11 12.4 7.4 1.8 1 1 0 1 1 1 0 Type III secretion protein YscO Pinin_SDK_memA PF04696.13 CDL00177.1 - 0.24 11.4 3.9 0.38 10.8 3.9 1.2 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region OEP PF02321.18 CDL00177.1 - 0.44 10.3 7.1 0.74 9.6 7.1 1.3 1 0 0 1 1 1 0 Outer membrane efflux protein Response_reg PF00072.24 CDL00178.1 - 1.2e-21 76.9 0.0 1.6e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDL00178.1 - 1.6e-13 50.5 0.0 4e-13 49.2 0.0 1.7 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal Bac_DnaA_C PF08299.11 CDL00179.1 - 3.4e-20 71.8 0.0 4.9e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Bacterial dnaA protein helix-turn-helix Abhydrolase_1 PF00561.20 CDL00180.1 - 8.2e-23 81.4 0.1 7e-21 75.0 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDL00180.1 - 8.8e-11 41.5 0.0 2.2e-08 33.7 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 CDL00180.1 - 1.8e-05 24.8 0.0 4.7e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 TAP-like protein Peptidase_S28 PF05577.12 CDL00180.1 - 0.0071 15.2 0.0 0.0099 14.7 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Ser_hydrolase PF06821.13 CDL00180.1 - 0.047 13.6 0.0 0.094 12.6 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Ndr PF03096.14 CDL00180.1 - 0.1 11.3 0.0 0.14 10.8 0.0 1.3 1 0 0 1 1 1 0 Ndr family Queuosine_synth PF02547.15 CDL00181.1 - 5.6e-127 423.3 0.0 6.3e-127 423.2 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein TGT PF01702.18 CDL00182.1 - 1e-141 472.2 0.0 1.3e-141 471.8 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Bac_globin PF01152.21 CDL00183.1 - 8.5e-08 32.4 0.0 1.1e-07 32.0 0.0 1.1 1 0 0 1 1 1 1 Bacterial-like globin TraH_2 PF06871.11 CDL00183.1 - 0.18 11.4 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 TraH_2 HSP33 PF01430.19 CDL00185.1 - 1.9e-73 247.2 0.0 2.2e-73 247.0 0.0 1.0 1 0 0 1 1 1 1 Hsp33 protein OTCace_N PF02729.21 CDL00186.1 - 5.1e-50 169.3 0.0 7.2e-50 168.9 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 CDL00186.1 - 6.1e-44 149.9 0.0 8.4e-44 149.4 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Aminotran_3 PF00202.21 CDL00187.1 - 6.8e-117 390.5 0.1 8.5e-117 390.2 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CDL00187.1 - 0.087 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Phasin_2 PF09361.10 CDL00188.1 - 1e-20 73.9 5.1 1.2e-20 73.6 5.1 1.1 1 0 0 1 1 1 1 Phasin protein PknG_TPR PF16918.5 CDL00188.1 - 0.001 17.9 1.0 0.0012 17.6 1.0 1.0 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat CBS PF00571.28 CDL00189.1 - 3.9e-24 84.9 2.9 3.1e-13 49.9 0.3 2.2 2 0 0 2 2 2 2 CBS domain HSP20 PF00011.21 CDL00190.1 - 1e-24 86.6 0.4 1.3e-24 86.3 0.4 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDL00190.1 - 3.3e-10 39.4 0.0 4.9e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Stealth_CR4 PF17103.5 CDL00190.1 - 0.11 12.4 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 Frataxin_Cyay PF01491.16 CDL00190.1 - 0.13 12.4 0.0 2 8.6 0.0 2.1 2 0 0 2 2 2 0 Frataxin-like domain FliP PF00813.20 CDL00191.1 - 6.6e-80 267.5 14.1 8e-80 267.2 14.1 1.1 1 0 0 1 1 1 1 FliP family FliO PF04347.13 CDL00192.1 - 6.6e-10 39.2 0.4 9.3e-10 38.7 0.4 1.2 1 0 0 1 1 1 1 Flagellar biosynthesis protein, FliO DUF3730 PF12530.8 CDL00193.1 - 0.087 12.4 0.0 0.098 12.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3730) Bac_export_2 PF01312.19 CDL00194.1 - 2.7e-19 69.6 6.5 3e-19 69.4 6.5 1.1 1 0 0 1 1 1 1 FlhB HrpN YscU SpaS Family LPD7 PF18821.1 CDL00194.1 - 0.017 15.3 1.1 0.038 14.1 0.6 1.8 1 1 1 2 2 2 0 Large polyvalent protein-associated domain 7 Flg_bb_rod PF00460.20 CDL00195.1 - 5.1e-06 26.3 0.4 1.1e-05 25.3 0.0 1.7 2 0 0 2 2 2 1 Flagella basal body rod protein Flg_bbr_C PF06429.13 CDL00196.1 - 1.8e-11 44.0 0.7 5.5e-11 42.5 0.7 1.8 1 1 0 1 1 1 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CDL00196.1 - 1.5e-06 27.9 0.1 1.5e-06 27.9 0.1 1.9 2 0 0 2 2 2 1 Flagella basal body rod protein FliE PF02049.18 CDL00197.1 - 1.4e-21 76.4 0.1 2e-21 75.9 0.1 1.2 1 0 0 1 1 1 1 Flagellar hook-basal body complex protein FliE Bac_export_3 PF01313.19 CDL00198.1 - 4.2e-27 93.9 6.2 4.7e-27 93.7 6.2 1.0 1 0 0 1 1 1 1 Bacterial export proteins, family 3 Tad PF13400.6 CDL00198.1 - 0.57 10.5 4.9 12 6.4 0.2 2.1 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like Bac_export_1 PF01311.20 CDL00199.1 - 3.4e-57 193.7 31.3 3.8e-57 193.5 31.3 1.0 1 0 0 1 1 1 1 Bacterial export proteins, family 1 Bac_export_2 PF01312.19 CDL00200.1 - 1.7e-123 412.0 3.7 1.9e-123 411.9 3.7 1.0 1 0 0 1 1 1 1 FlhB HrpN YscU SpaS Family PAS_4 PF08448.10 CDL00201.1 - 2.9e-26 91.9 4.9 2.3e-14 53.6 0.0 4.6 3 2 1 4 4 4 3 PAS fold Response_reg PF00072.24 CDL00201.1 - 1.4e-20 73.6 0.1 2.7e-20 72.6 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 CDL00201.1 - 1.3e-17 64.4 0.0 2.8e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 CDL00201.1 - 4.1e-14 52.7 0.0 4.5e-05 23.6 0.0 3.6 3 0 0 3 3 3 2 PAS domain PAS PF00989.25 CDL00201.1 - 5.3e-14 52.2 0.0 6.7e-05 22.9 0.0 4.6 3 2 0 3 3 3 2 PAS fold PAS_8 PF13188.7 CDL00201.1 - 1.5e-09 37.6 0.3 8.2e-05 22.5 0.1 3.3 2 0 0 2 2 2 2 PAS domain HisKA PF00512.25 CDL00201.1 - 6.1e-09 35.8 0.5 2.7e-08 33.7 0.1 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain DUF212 PF02681.14 CDL00201.1 - 0.14 12.3 1.5 28 4.9 0.8 2.8 3 0 0 3 3 3 0 Divergent PAP2 family RecA PF00154.21 CDL00202.1 - 4e-145 482.1 2.0 4.9e-145 481.9 2.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein Rad51 PF08423.11 CDL00202.1 - 2e-11 43.6 0.4 5.4e-11 42.2 0.4 1.6 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 CDL00202.1 - 4.9e-09 35.9 0.4 1.1e-07 31.5 0.4 2.6 1 1 0 1 1 1 1 KaiC ATPase_2 PF01637.18 CDL00202.1 - 1.9e-05 24.7 0.0 3.5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 CDL00202.1 - 6.8e-05 23.3 0.1 0.00013 22.4 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 CDL00202.1 - 0.00011 22.0 0.0 0.00018 21.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CDL00202.1 - 0.0017 18.0 0.3 0.022 14.4 0.3 2.3 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CDL00202.1 - 0.0019 18.7 0.0 0.0039 17.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_35 PF14516.6 CDL00202.1 - 0.01 14.7 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain CobU PF02283.16 CDL00202.1 - 0.017 14.7 0.0 0.043 13.4 0.0 1.6 1 1 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA_22 PF13401.6 CDL00202.1 - 0.023 15.0 0.0 0.04 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDL00202.1 - 0.036 14.6 0.0 0.07 13.6 0.0 1.7 1 1 0 1 1 1 0 ABC transporter CLP1_P PF16575.5 CDL00202.1 - 0.09 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MobB PF03205.14 CDL00202.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SecA_DEAD PF07517.14 CDL00203.1 - 3.4e-132 440.1 0.5 5.6e-132 439.4 0.5 1.3 1 0 0 1 1 1 1 SecA DEAD-like domain SecA_SW PF07516.13 CDL00203.1 - 8e-66 221.9 7.2 8e-66 221.9 7.2 1.9 2 1 0 2 2 2 1 SecA Wing and Scaffold domain SecA_PP_bind PF01043.20 CDL00203.1 - 2.2e-38 131.3 1.3 1.2e-37 128.9 0.8 2.5 2 0 0 2 2 2 1 SecA preprotein cross-linking domain SEC-C PF02810.15 CDL00203.1 - 2.3e-10 40.2 8.2 3.6e-10 39.6 8.2 1.3 1 0 0 1 1 1 1 SEC-C motif DEAD PF00270.29 CDL00203.1 - 3.9e-05 23.5 0.1 0.00024 20.9 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDL00203.1 - 0.0033 17.8 2.0 0.042 14.2 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HATPase_c PF02518.26 CDL00204.1 - 2.4e-20 73.1 0.0 4.3e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_8 PF13188.7 CDL00204.1 - 5.2e-08 32.7 0.0 1.4e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 PAS domain HisKA PF00512.25 CDL00204.1 - 4e-07 30.0 0.4 1.9e-06 27.8 0.1 2.3 2 1 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CDL00204.1 - 1.1e-06 28.7 0.0 2.1e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDL00204.1 - 2.9e-05 24.3 0.0 5.7e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDL00204.1 - 0.0018 18.5 0.1 0.0044 17.3 0.1 1.7 1 0 0 1 1 1 1 PAS fold NrsF PF06532.11 CDL00204.1 - 0.023 14.4 2.0 0.038 13.7 2.0 1.3 1 0 0 1 1 1 0 Negative regulator of sigma F Rotamase_3 PF13616.6 CDL00205.1 - 3.3e-25 88.9 0.9 7.8e-25 87.7 0.1 2.0 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase PF00639.21 CDL00205.1 - 3.8e-23 82.3 2.0 3.8e-23 82.2 0.4 1.9 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 CDL00205.1 - 1.1e-17 65.0 2.8 1.1e-17 65.0 2.8 2.4 3 0 0 3 3 3 1 PPIC-type PPIASE domain SurA_N_3 PF13624.6 CDL00205.1 - 0.0006 19.6 1.2 0.0021 17.9 0.5 2.3 2 1 0 2 2 2 1 SurA N-terminal domain SurA_N_2 PF13623.6 CDL00205.1 - 0.0029 17.5 0.7 0.018 14.9 0.7 2.2 1 1 0 1 1 1 1 SurA N-terminal domain ArgJ PF01960.18 CDL00206.1 - 9.4e-138 459.0 11.0 1.1e-137 458.8 11.0 1.0 1 0 0 1 1 1 1 ArgJ family Acetyltransf_3 PF13302.7 CDL00207.1 - 9e-32 110.6 0.0 2.6e-31 109.1 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain NUDIX PF00293.28 CDL00207.1 - 1.3e-17 64.1 0.0 2.3e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 CDL00207.1 - 7.4e-17 61.3 0.0 1.3e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Acetyltransf_1 PF00583.25 CDL00207.1 - 1e-09 38.6 0.0 1.7e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 CDL00207.1 - 1.1e-05 25.2 0.0 6.9e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDL00207.1 - 0.0055 16.6 0.0 0.02 14.9 0.0 1.9 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_4 PF13420.7 CDL00207.1 - 0.086 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Autoind_bind PF03472.15 CDL00208.1 - 0.07 12.6 0.2 0.43 10.1 0.0 1.9 1 1 1 2 2 2 0 Autoinducer binding domain CPBP PF02517.16 CDL00208.1 - 0.15 12.5 3.2 0.25 11.7 3.2 1.5 1 1 0 1 1 1 0 CPBP intramembrane metalloprotease COX7a PF02238.15 CDL00208.1 - 1.5 9.3 6.9 1.7 9.1 0.5 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII Flg_hook PF02120.16 CDL00209.1 - 2.9e-17 62.3 5.8 7.5e-17 61.0 0.2 2.7 2 0 0 2 2 2 2 Flagellar hook-length control protein FliK FlgD PF03963.14 CDL00210.1 - 8.6e-21 74.0 5.0 2e-20 72.9 5.0 1.6 1 0 0 1 1 1 1 Flagellar hook capping protein - N-terminal region FlgD_ig PF13860.6 CDL00210.1 - 1.7e-17 63.1 0.5 4.8e-17 61.6 0.5 1.8 1 0 0 1 1 1 1 FlgD Ig-like domain FLgD_tudor PF13861.6 CDL00210.1 - 8.8e-06 25.9 0.3 1.5e-05 25.2 0.3 1.4 1 0 0 1 1 1 1 FlgD Tudor-like domain DUF2271 PF10029.9 CDL00210.1 - 0.00086 18.9 0.5 0.0014 18.2 0.5 1.5 1 1 0 1 1 1 1 Predicted periplasmic protein (DUF2271) Big_6 PF17936.1 CDL00210.1 - 0.033 14.5 3.7 0.28 11.5 1.8 2.9 1 1 1 2 2 2 0 Bacterial Ig domain MG4 PF17789.1 CDL00210.1 - 0.091 12.9 0.9 0.57 10.4 0.1 2.5 1 1 1 2 2 2 0 Macroglobulin domain MG4 Flg_bbr_C PF06429.13 CDL00211.1 - 6.1e-19 67.9 0.2 6.1e-19 67.9 0.2 2.2 2 0 0 2 2 2 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CDL00211.1 - 1.8e-07 30.9 0.3 1.8e-07 30.9 0.3 3.2 2 0 0 2 2 2 1 Flagella basal body rod protein FlaE PF07559.14 CDL00211.1 - 0.04 14.5 16.1 4.9 7.8 16.1 3.3 1 1 0 1 1 1 0 Flagellar basal body protein FlaE DUF779 PF05610.11 CDL00212.1 - 6e-49 164.3 0.0 6.9e-49 164.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF779) Aldedh PF00171.22 CDL00213.1 - 5.4e-161 536.2 0.0 6.1e-161 536.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CDL00213.1 - 0.067 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Sigma54_activat PF00158.26 CDL00214.1 - 1.3e-61 207.2 0.0 2.1e-61 206.5 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CDL00214.1 - 2.2e-18 66.7 0.0 6.4e-18 65.2 0.0 1.8 1 1 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CDL00214.1 - 1.3e-12 47.2 0.4 1.3e-12 47.2 0.4 2.4 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family GAF PF01590.26 CDL00214.1 - 5.9e-09 36.7 0.2 1.6e-08 35.3 0.2 1.8 1 0 0 1 1 1 1 GAF domain HTH_30 PF13556.6 CDL00214.1 - 5.7e-07 29.2 0.1 3.8e-06 26.6 0.1 2.6 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain AAA_5 PF07728.14 CDL00214.1 - 3.9e-06 26.9 0.0 9.2e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CDL00214.1 - 6.6e-05 22.4 0.2 0.0099 15.3 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 CDL00214.1 - 0.00025 21.5 0.0 0.00043 20.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) HTH_23 PF13384.6 CDL00214.1 - 0.0017 18.1 0.0 0.0044 16.8 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 CDL00214.1 - 0.0033 17.5 0.1 0.014 15.5 0.1 2.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_22 PF13309.6 CDL00214.1 - 0.0047 17.0 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 HTH domain HTH_psq PF05225.16 CDL00214.1 - 0.0061 16.3 0.0 0.0061 16.3 0.0 2.2 3 0 0 3 3 1 1 helix-turn-helix, Psq domain HTH_7 PF02796.15 CDL00214.1 - 0.011 15.8 0.0 0.028 14.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase AAA_3 PF07726.11 CDL00214.1 - 0.012 15.4 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) HTH_29 PF13551.6 CDL00214.1 - 0.016 15.2 0.2 0.11 12.5 0.1 2.5 2 0 0 2 2 2 0 Winged helix-turn helix HTH_1 PF00126.27 CDL00214.1 - 0.02 14.8 0.3 0.18 11.8 0.0 2.7 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_17 PF12728.7 CDL00214.1 - 0.022 15.0 0.0 0.057 13.6 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain AAA_2 PF07724.14 CDL00214.1 - 0.04 14.0 0.0 0.11 12.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) HTH_3 PF01381.22 CDL00214.1 - 0.058 13.5 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix PAS PF00989.25 CDL00214.1 - 0.066 13.2 0.0 0.24 11.4 0.0 2.0 1 0 0 1 1 1 0 PAS fold Pyr_redox_2 PF07992.14 CDL00215.1 - 5.2e-29 101.4 0.1 6e-29 101.2 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDL00215.1 - 6.8e-21 74.8 0.0 6.1e-18 65.1 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDL00215.1 - 2.4e-10 40.8 1.8 2.6e-09 37.5 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDL00215.1 - 1.4e-08 33.9 0.2 0.00088 18.1 0.6 3.6 4 0 0 4 4 4 2 HI0933-like protein NAD_binding_8 PF13450.6 CDL00215.1 - 0.00042 20.5 0.0 0.0013 19.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CDL00215.1 - 0.0013 18.8 0.1 0.2 11.6 0.0 2.7 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_oxidored PF12831.7 CDL00215.1 - 0.0013 18.2 0.3 0.029 13.7 0.1 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 CDL00215.1 - 0.0014 19.0 0.8 0.0075 16.7 0.0 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding K_oxygenase PF13434.6 CDL00215.1 - 0.0024 17.0 0.1 0.012 14.8 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 CDL00215.1 - 0.0025 17.1 3.4 0.0028 16.9 0.2 2.3 3 0 0 3 3 3 1 Thi4 family FAD_binding_2 PF00890.24 CDL00215.1 - 0.0032 16.6 2.0 0.0032 16.6 2.0 2.8 2 1 0 3 3 3 1 FAD binding domain Lycopene_cycl PF05834.12 CDL00215.1 - 0.0058 15.7 2.5 1.6 7.7 1.2 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein Oxidored_nitro PF00148.19 CDL00215.1 - 0.017 13.9 0.0 0.024 13.4 0.0 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase FMO-like PF00743.19 CDL00215.1 - 0.018 13.5 0.5 0.035 12.5 0.0 1.6 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like AlaDh_PNT_C PF01262.21 CDL00215.1 - 0.021 14.1 0.4 3 7.1 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 CDL00215.1 - 0.034 13.4 0.2 0.12 11.7 0.1 1.8 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 CDL00215.1 - 0.076 12.6 3.4 7.9 5.9 0.0 2.7 1 1 2 3 3 3 0 FAD dependent oxidoreductase GIDA PF01134.22 CDL00215.1 - 0.19 10.8 7.0 7.5 5.5 1.3 3.4 2 1 1 4 4 4 0 Glucose inhibited division protein A Hydrolase_6 PF13344.6 CDL00216.1 - 6e-14 52.0 0.0 1.1e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDL00216.1 - 1.1e-13 51.0 0.2 2.3e-13 50.0 0.2 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 CDL00216.1 - 9e-10 39.2 0.8 5.5e-07 30.1 0.1 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDL00216.1 - 9e-09 35.7 0.0 4.8e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase GerPE PF10970.8 CDL00216.1 - 0.23 11.6 0.0 0.4 10.9 0.0 1.3 1 0 0 1 1 1 0 Spore germination protein GerPE DHO_dh PF01180.21 CDL00217.1 - 2.1e-93 312.7 0.0 2.5e-93 312.5 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 CDL00217.1 - 0.0013 18.1 1.6 0.002 17.6 1.6 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase CENP-R PF06729.12 CDL00217.1 - 0.23 11.4 0.0 0.38 10.7 0.0 1.2 1 0 0 1 1 1 0 Kinetochore component, CENP-R DUF952 PF06108.12 CDL00218.1 - 1.1e-30 105.5 0.0 1.2e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) NnrU PF07298.11 CDL00219.1 - 2.2e-53 180.9 14.0 2.5e-53 180.7 14.0 1.0 1 0 0 1 1 1 1 NnrU protein DUF1295 PF06966.12 CDL00219.1 - 0.034 13.7 0.7 0.053 13.0 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) Colicin_V PF02674.16 CDL00219.1 - 0.074 13.0 0.2 0.074 13.0 0.2 2.3 2 1 0 2 2 2 0 Colicin V production protein Tmemb_14 PF03647.13 CDL00219.1 - 0.75 10.6 5.2 19 6.0 2.6 2.6 2 1 0 2 2 2 0 Transmembrane proteins 14C THF_DHG_CYH_C PF02882.19 CDL00220.1 - 5.3e-65 217.6 0.7 7.9e-65 217.0 0.7 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 CDL00220.1 - 1.9e-40 137.8 0.0 2.8e-40 137.2 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain DUF167 PF02594.16 CDL00221.1 - 1.9e-24 85.6 0.1 2.2e-24 85.3 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 YGGT PF02325.17 CDL00222.1 - 4.3e-17 62.3 5.9 6.2e-17 61.8 5.9 1.2 1 0 0 1 1 1 1 YGGT family Hemerythrin PF01814.23 CDL00223.1 - 9.9e-06 26.2 2.2 1.2e-05 25.9 2.2 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain HEAT_2 PF13646.6 CDL00223.1 - 0.027 14.8 0.2 0.053 13.9 0.2 1.4 1 0 0 1 1 1 0 HEAT repeats DUF1566 PF07603.11 CDL00224.1 - 1.1e-42 145.1 0.0 4e-20 72.3 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1566) ADH_zinc_N PF00107.26 CDL00225.1 - 9.9e-31 106.4 0.4 9.9e-31 106.4 0.4 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDL00225.1 - 6.5e-23 82.3 0.1 1.5e-22 81.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDL00225.1 - 2.3e-14 53.2 0.1 5.1e-14 52.1 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CDL00225.1 - 0.11 11.9 2.7 0.22 11.0 2.7 1.5 1 0 0 1 1 1 0 short chain dehydrogenase DsrC PF04358.13 CDL00227.1 - 2.3e-37 127.8 0.0 2.6e-37 127.6 0.0 1.0 1 0 0 1 1 1 1 DsrC like protein SUKH-3 PF14433.6 CDL00227.1 - 0.043 14.3 0.1 0.051 14.0 0.1 1.1 1 0 0 1 1 1 0 SUKH-3 immunity protein SUIM_assoc PF16619.5 CDL00227.1 - 0.11 12.6 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 NUDIX PF00293.28 CDL00229.1 - 6.5e-11 42.4 0.6 8.5e-11 42.0 0.6 1.1 1 0 0 1 1 1 1 NUDIX domain Nudix_N_2 PF14803.6 CDL00229.1 - 2.9e-07 30.3 0.1 5.2e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Nudix N-terminal NapD PF03927.13 CDL00229.1 - 0.027 14.5 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 NapD protein Cys_rich_CPCC PF14206.6 CDL00229.1 - 0.14 12.0 0.6 0.26 11.1 0.6 1.4 1 0 0 1 1 1 0 Cysteine-rich CPCC PseudoU_synth_1 PF01416.20 CDL00230.1 - 1.1e-41 141.7 0.2 5.9e-29 100.7 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase Sigma70_ner PF04546.13 CDL00231.1 - 3.8e-50 170.6 0.1 3.8e-50 170.6 0.1 3.1 4 0 0 4 4 4 1 Sigma-70, non-essential region Sigma70_r3 PF04539.16 CDL00231.1 - 7.8e-30 102.8 2.1 1.6e-29 101.8 0.7 2.3 2 0 0 2 2 2 1 Sigma-70 region 3 Sigma70_r1_1 PF03979.14 CDL00231.1 - 4.1e-24 84.4 2.2 6.2e-24 83.9 0.5 2.2 2 0 0 2 2 2 1 Sigma-70 factor, region 1.1 Sigma70_r2 PF04542.14 CDL00231.1 - 8.1e-22 76.8 0.3 2.1e-21 75.4 0.3 1.8 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4 PF04545.16 CDL00231.1 - 1.5e-20 72.5 3.8 1.7e-18 65.8 1.1 2.6 2 0 0 2 2 2 2 Sigma-70, region 4 Sigma70_r1_2 PF00140.20 CDL00231.1 - 8e-14 51.4 3.6 1.3e-13 50.7 0.4 3.0 3 0 0 3 3 3 1 Sigma-70 factor, region 1.2 HTH_15 PF12324.8 CDL00231.1 - 0.011 15.6 0.5 2.2 8.3 0.0 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain of alkylmercury lyase EFhand_Ca_insen PF08726.10 CDL00231.1 - 0.039 14.0 0.0 0.14 12.2 0.0 1.9 1 0 0 1 1 1 0 Ca2+ insensitive EF hand BRE1 PF08647.11 CDL00231.1 - 0.076 13.1 3.9 0.12 12.4 0.9 2.6 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase HTH_25 PF13413.6 CDL00231.1 - 0.2 11.6 2.3 21 5.0 0.0 3.7 3 0 0 3 3 3 0 Helix-turn-helix domain Toprim_N PF08275.11 CDL00232.1 - 3.3e-38 130.6 0.0 1e-37 129.0 0.0 1.9 2 0 0 2 2 2 1 DNA primase catalytic core, N-terminal domain zf-CHC2 PF01807.20 CDL00232.1 - 8.1e-36 121.8 0.0 1.5e-35 120.9 0.0 1.4 1 0 0 1 1 1 1 CHC2 zinc finger Toprim_4 PF13662.6 CDL00232.1 - 9.7e-17 61.2 0.0 1.8e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Toprim domain Toprim_2 PF13155.6 CDL00232.1 - 8.3e-13 48.6 0.0 2.1e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 Toprim-like Toprim_3 PF13362.6 CDL00232.1 - 2.7e-05 24.5 0.0 5.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Toprim domain Toprim PF01751.22 CDL00232.1 - 5e-05 23.5 0.0 0.00011 22.4 0.0 1.6 1 0 0 1 1 1 1 Toprim domain YqeY PF09424.10 CDL00233.1 - 2.4e-45 154.1 3.8 2.7e-45 154.0 3.8 1.0 1 0 0 1 1 1 1 Yqey-like protein CPSase_sm_chain PF00988.22 CDL00234.1 - 1.5e-49 167.1 0.0 2.5e-49 166.4 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 CDL00234.1 - 3.3e-46 157.5 0.0 4.4e-46 157.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CDL00234.1 - 1.2e-10 41.5 0.7 3.9e-08 33.3 0.6 2.7 1 1 1 2 2 2 1 Peptidase C26 CPSase_L_D2 PF02786.17 CDL00235.1 - 2.4e-107 357.2 0.1 9.9e-66 221.2 0.0 2.4 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 CDL00235.1 - 3.9e-38 130.5 0.0 8.5e-38 129.4 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain MGS PF02142.22 CDL00235.1 - 4.2e-22 78.1 0.1 2.3e-21 75.8 0.0 2.4 3 0 0 3 3 3 1 MGS-like domain ATP-grasp PF02222.22 CDL00235.1 - 2.6e-13 49.9 0.0 3.7e-08 33.1 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 CDL00235.1 - 2.2e-11 43.6 0.0 6.2e-07 29.2 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 CDL00235.1 - 4.4e-09 36.6 0.1 7.1e-06 26.2 0.0 3.4 3 0 0 3 3 3 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CDL00235.1 - 5.6e-08 32.6 0.0 0.00029 20.5 0.0 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp_4 PF13535.6 CDL00235.1 - 1.3e-05 24.8 0.5 0.026 14.1 0.0 4.3 4 2 0 4 4 4 1 ATP-grasp domain ATP-grasp_5 PF13549.6 CDL00235.1 - 0.00032 20.2 0.0 0.0059 16.1 0.0 2.5 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_2 PF08442.10 CDL00235.1 - 0.019 14.6 0.0 11 5.5 0.0 3.0 2 1 0 2 2 2 0 ATP-grasp domain DUF433 PF04255.14 CDL00235.1 - 0.044 13.6 0.0 3.1 7.7 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF433) GreA_GreB_N PF03449.15 CDL00236.1 - 3.4e-31 107.2 1.1 4.6e-31 106.8 1.1 1.2 1 0 0 1 1 1 1 Transcription elongation factor, N-terminal GreA_GreB PF01272.19 CDL00236.1 - 2.1e-30 104.4 0.2 3.1e-30 103.9 0.2 1.2 1 0 0 1 1 1 1 Transcription elongation factor, GreA/GreB, C-term PapC_C PF13953.6 CDL00236.1 - 0.049 13.5 0.0 0.08 12.8 0.0 1.3 1 0 0 1 1 1 0 PapC C-terminal domain WD40_alt PF14077.6 CDL00236.1 - 0.14 12.0 0.0 2.9 7.8 0.0 2.3 2 0 0 2 2 2 0 Alternative WD40 repeat motif BACON PF13004.7 CDL00237.1 - 0.065 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative binding domain, N-terminal BON PF04972.17 CDL00238.1 - 9.2e-15 54.7 6.7 5.2e-10 39.5 0.3 2.2 2 0 0 2 2 2 2 BON domain SNARE_assoc PF09335.11 CDL00239.1 - 1.8e-19 70.4 13.0 5.2e-19 68.9 8.7 2.4 1 1 1 2 2 2 1 SNARE associated Golgi protein Phage_holin_3_6 PF07332.11 CDL00239.1 - 0.0054 16.8 1.5 0.0054 16.8 1.5 3.1 2 1 1 3 3 3 1 Putative Actinobacterial Holin-X, holin superfamily III PA28_alpha PF02251.18 CDL00239.1 - 0.14 12.2 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Proteasome activator pa28 alpha subunit MHYT PF03707.16 CDL00239.1 - 0.2 11.8 0.2 0.2 11.8 0.2 3.2 3 1 0 3 3 3 0 Bacterial signalling protein N terminal repeat DUF4381 PF14316.6 CDL00239.1 - 0.25 11.6 1.1 0.77 10.0 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) DUF4199 PF13858.6 CDL00239.1 - 4.8 7.6 9.5 23 5.4 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) Glycos_transf_2 PF00535.26 CDL00240.1 - 5.4e-23 81.6 0.0 9.4e-23 80.9 0.0 1.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDL00240.1 - 1.7e-10 41.2 0.2 4.3e-10 39.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CDL00240.1 - 0.018 15.5 0.0 0.037 14.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 CDL00240.1 - 0.085 12.3 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase like family 2 ACCA PF03255.14 CDL00241.1 - 6e-61 204.5 0.0 8.4e-61 204.1 0.0 1.2 1 0 0 1 1 1 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Carboxyl_trans PF01039.22 CDL00241.1 - 9.8e-21 73.9 0.2 1.3e-20 73.5 0.2 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain SLT PF01464.20 CDL00242.1 - 1.4e-26 92.4 0.1 2.9e-26 91.4 0.1 1.4 1 0 0 1 1 1 1 Transglycosylase SLT domain TPR_4 PF07721.14 CDL00242.1 - 0.0059 17.1 0.3 0.0059 17.1 0.3 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDL00242.1 - 0.033 14.8 2.0 0.033 14.8 2.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Bac_globin PF01152.21 CDL00242.1 - 0.047 13.8 0.0 14 5.9 0.0 2.3 2 0 0 2 2 2 0 Bacterial-like globin Phage_lysozyme2 PF18013.1 CDL00242.1 - 0.094 12.7 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 Phage tail lysozyme TPR_2 PF07719.17 CDL00242.1 - 0.13 12.4 1.8 0.6 10.4 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDL00242.1 - 0.43 11.3 3.1 1.9 9.3 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDL00242.1 - 7.5 7.7 7.1 6.1 7.9 0.0 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat UDG PF03167.19 CDL00243.1 - 3.3e-44 150.6 0.0 4.6e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily ETF_QO PF05187.13 CDL00244.1 - 4.4e-48 161.7 0.1 7e-48 161.1 0.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 CDL00244.1 - 1.3e-09 38.1 0.6 0.0006 19.5 0.2 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDL00244.1 - 6.1e-09 35.4 0.1 2.9e-05 23.4 0.2 2.1 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 CDL00244.1 - 1e-07 31.5 0.0 3.1e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CDL00244.1 - 7.2e-07 29.4 0.0 4.7e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CDL00244.1 - 4.2e-05 22.4 0.1 6.2e-05 21.9 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 CDL00244.1 - 0.00036 19.9 0.1 0.00054 19.3 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDL00244.1 - 0.00041 20.8 0.0 0.93 10.1 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDL00244.1 - 0.00047 19.5 0.0 0.00067 19.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDL00244.1 - 0.00077 18.6 1.2 0.00099 18.3 0.1 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 CDL00244.1 - 0.00088 18.6 0.8 0.0063 15.8 0.1 2.3 2 1 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 CDL00244.1 - 0.017 14.0 0.1 0.75 8.6 0.1 2.3 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_9 PF13454.6 CDL00244.1 - 0.018 15.0 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 CDL00244.1 - 0.022 13.9 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 CDL00244.1 - 0.027 13.8 0.1 0.042 13.2 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Mqo PF06039.15 CDL00244.1 - 0.11 11.0 0.0 0.16 10.5 0.0 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) TPR_2 PF07719.17 CDL00246.1 - 4.1e-27 92.1 30.0 6.7e-05 22.7 0.2 11.2 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_1 PF00515.28 CDL00246.1 - 2.1e-24 84.3 12.2 8.1e-06 25.4 0.0 9.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 CDL00246.1 - 3.8e-24 82.8 10.2 4.6e-05 23.3 0.1 10.5 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDL00246.1 - 2.3e-20 73.0 60.6 2.4e-06 28.1 0.6 8.8 6 3 3 9 9 9 7 Tetratricopeptide repeat TPR_19 PF14559.6 CDL00246.1 - 1.2e-19 70.5 37.9 0.00012 22.6 1.5 8.1 7 1 1 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.6 CDL00246.1 - 2e-16 59.2 52.1 0.0013 19.4 0.1 12.7 6 4 7 13 13 12 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDL00246.1 - 4.4e-14 51.9 18.8 2.4e-06 27.1 0.2 7.5 7 1 1 8 8 8 4 TPR repeat TPR_6 PF13174.6 CDL00246.1 - 1.3e-13 50.6 37.1 0.016 15.8 0.0 10.6 12 0 0 12 12 10 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDL00246.1 - 2.2e-13 50.3 35.1 0.0029 17.9 0.2 9.9 9 2 0 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDL00246.1 - 2.4e-11 42.8 22.8 0.0018 18.2 0.0 9.2 10 1 1 11 11 10 4 Tetratricopeptide repeat TPR_17 PF13431.6 CDL00246.1 - 3.6e-10 39.5 5.9 0.0043 17.3 0.0 7.7 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDL00246.1 - 1e-09 38.1 21.6 5.6e-08 32.3 1.5 4.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDL00246.1 - 7.2e-09 35.7 32.0 0.0023 18.0 0.2 7.9 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_21 PF09976.9 CDL00246.1 - 7.8e-08 32.3 21.8 0.00074 19.3 0.6 5.9 3 1 1 6 6 6 3 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 CDL00246.1 - 0.0002 21.1 42.5 0.0011 18.8 0.1 10.4 11 0 0 11 11 11 1 Tetratricopeptide repeat BTAD PF03704.17 CDL00246.1 - 0.00033 21.1 0.1 0.00033 21.1 0.1 4.2 4 3 1 5 5 5 1 Bacterial transcriptional activator domain ANAPC3 PF12895.7 CDL00246.1 - 0.0025 18.0 2.8 0.23 11.7 0.0 4.7 3 2 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 CDL00246.1 - 0.015 15.3 0.1 0.15 12.2 0.0 2.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 CDL00246.1 - 0.023 15.3 1.4 0.023 15.3 1.4 11.0 13 0 0 13 13 9 0 Tetratricopeptide repeat NARP1 PF12569.8 CDL00246.1 - 0.025 13.5 0.1 0.36 9.7 0.0 2.7 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 DUF3808 PF10300.9 CDL00246.1 - 0.22 10.2 0.0 0.45 9.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) GHMP_kinases_C PF08544.13 CDL00247.1 - 1.9e-09 37.7 0.4 5.5e-09 36.3 0.4 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 CDL00247.1 - 2.1e-08 34.2 0.3 2.1e-08 34.2 0.3 2.5 3 0 0 3 3 3 1 GHMP kinases N terminal domain 3-alpha PF03475.14 CDL00247.1 - 8.6 6.3 11.3 10 6.1 1.4 3.9 3 0 0 3 3 3 0 3-alpha domain Phage_int_SAM_1 PF02899.17 CDL00248.1 - 0.012 15.9 0.3 0.72 10.2 0.5 2.8 1 1 1 2 2 2 0 Phage integrase, N-terminal SAM-like domain MutS_III PF05192.18 CDL00248.1 - 0.029 14.6 0.3 0.36 11.0 0.0 2.3 2 1 0 2 2 2 0 MutS domain III Phage_int_SAM_4 PF13495.6 CDL00248.1 - 0.084 13.4 0.1 12 6.5 0.0 2.7 1 1 1 2 2 2 0 Phage integrase, N-terminal SAM-like domain LPD11 PF18824.1 CDL00248.1 - 0.11 12.6 0.0 0.49 10.5 0.0 2.1 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 11 DDE_Tnp_IS66 PF03050.14 CDL00249.1 - 2.9e-89 299.3 0.4 4.9e-89 298.6 0.0 1.6 2 0 0 2 2 2 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDL00249.1 - 2.9e-18 65.8 0.0 1e-17 64.0 0.0 2.0 1 0 0 1 1 1 1 IS66 C-terminal element LZ_Tnp_IS66 PF13007.7 CDL00249.1 - 3e-16 59.9 4.3 3e-16 59.9 4.3 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDL00249.1 - 1.5e-15 57.3 4.6 2.9e-15 56.4 4.6 1.5 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDL00249.1 - 0.18 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.12 CDL00249.1 - 1.1 10.0 3.9 11 6.8 2.2 2.9 2 1 1 3 3 3 0 SlyX TnpB_IS66 PF05717.13 CDL00250.1 - 9.3e-38 128.2 0.0 1e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein HTH_Tnp_1 PF01527.20 CDL00251.1 - 2.4e-16 59.8 0.3 3.3e-16 59.4 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDL00251.1 - 3.3e-06 26.7 0.0 5.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 CDL00251.1 - 0.0068 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 CDL00251.1 - 0.017 15.2 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 CDL00251.1 - 0.039 13.6 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Phage_integrase PF00589.22 CDL00252.1 - 2.6e-25 89.2 0.1 4.2e-25 88.5 0.1 1.3 1 1 0 1 1 1 1 Phage integrase family Methyltransf_23 PF13489.6 CDL00253.1 - 1.1e-11 44.8 0.0 1.4e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL00253.1 - 4.3e-10 40.1 0.0 6.2e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL00253.1 - 5.6e-10 39.8 0.0 8.6e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00253.1 - 7.4e-10 38.8 0.0 1e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00253.1 - 1.1e-07 32.4 0.0 1.9e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 CDL00253.1 - 7.5e-05 22.4 0.0 0.0001 22.0 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 CDL00253.1 - 0.00051 19.6 0.1 0.00069 19.2 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 CDL00253.1 - 0.0047 16.4 0.0 0.0062 16.0 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB CMAS PF02353.20 CDL00253.1 - 0.0047 16.3 0.0 0.0076 15.6 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 CDL00253.1 - 0.025 14.0 0.2 0.035 13.5 0.2 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Phage_integrase PF00589.22 CDL00255.1 - 1.6e-27 96.4 0.1 1.8e-27 96.2 0.1 1.0 1 0 0 1 1 1 1 Phage integrase family Hairy_orange PF07527.13 CDL00255.1 - 0.0012 19.0 0.0 1.9 8.8 0.0 2.7 3 0 0 3 3 3 2 Hairy Orange MethyltransfD12 PF02086.15 CDL00258.1 - 7.5e-13 48.8 0.0 7.9e-12 45.4 0.0 2.0 1 1 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase GHL6 PF14871.6 CDL00258.1 - 0.036 14.2 0.0 0.07 13.3 0.0 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 RsmJ PF04378.13 CDL00258.1 - 0.036 13.3 0.0 0.062 12.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA large subunit methyltransferase D, RlmJ DUF2294 PF10057.9 CDL00260.1 - 0.00045 20.3 0.0 0.0022 18.1 0.0 2.1 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2294) DUF4635 PF15466.6 CDL00260.1 - 0.021 14.4 0.1 0.032 13.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) Dynein_light PF01221.18 CDL00260.1 - 0.036 14.4 0.3 0.25 11.7 0.1 2.0 2 0 0 2 2 2 0 Dynein light chain type 1 N6_Mtase PF02384.16 CDL00261.1 - 2.1e-113 378.7 0.0 2.7e-113 378.4 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase HsdM_N PF12161.8 CDL00261.1 - 7e-26 91.5 0.1 1.6e-25 90.3 0.1 1.6 1 0 0 1 1 1 1 HsdM N-terminal domain MTS PF05175.14 CDL00261.1 - 0.0095 15.5 0.0 0.028 14.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain AviRa PF11599.8 CDL00261.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Methylase_S PF01420.19 CDL00262.1 - 1.5e-24 87.1 0.0 3.1e-18 66.6 0.0 2.1 2 0 0 2 2 2 2 Type I restriction modification DNA specificity domain DUF3387 PF11867.8 CDL00263.1 - 6e-121 403.9 8.6 9.6e-121 403.2 8.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3387) SWI2_SNF2 PF18766.1 CDL00263.1 - 3.4e-83 278.7 0.0 7.9e-83 277.5 0.0 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase HSDR_N PF04313.14 CDL00263.1 - 8.5e-42 143.3 0.0 2.8e-41 141.6 0.0 1.9 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) ResIII PF04851.15 CDL00263.1 - 9.3e-15 55.0 0.0 2.1e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Thr_synth_N PF14821.6 CDL00263.1 - 0.033 14.4 0.0 17 5.7 0.0 2.9 2 0 0 2 2 2 0 Threonine synthase N terminus eRF1_3 PF03465.15 CDL00263.1 - 0.04 14.4 0.1 0.35 11.4 0.0 2.4 2 0 0 2 2 2 0 eRF1 domain 3 DUF2075 PF09848.9 CDL00263.1 - 0.079 12.2 0.1 14 4.8 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Transposase_22 PF02994.14 CDL00264.1 - 0.021 15.0 0.1 0.066 13.4 0.0 1.8 2 0 0 2 2 2 0 L1 transposable element RBD-like domain Ribosomal_L2 PF00181.23 CDL00264.1 - 0.07 13.1 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Ribosomal Proteins L2, RNA binding domain Phage_CI_repr PF07022.13 CDL00267.1 - 0.0023 18.0 0.0 0.0033 17.5 0.0 1.2 1 0 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain DUF1663 PF07909.11 CDL00267.1 - 0.048 12.4 0.0 0.055 12.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1663) FPV060 PF17614.2 CDL00273.1 - 0.036 13.5 0.0 0.06 12.7 0.0 1.3 1 1 0 1 1 1 0 Viral CC-type chemokine DUF1566 PF07603.11 CDL00274.1 - 0.035 14.5 0.0 0.039 14.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1566) DDE_3 PF13358.6 CDL00275.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL00275.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDL00276.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL00276.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL00276.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL00276.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL00276.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL00276.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain PhdYeFM_antitox PF02604.19 CDL00281.1 - 8.6e-14 51.1 0.1 1e-13 50.8 0.1 1.1 1 0 0 1 1 1 1 Antitoxin Phd_YefM, type II toxin-antitoxin system ParE_toxin PF05016.15 CDL00282.1 - 6.2e-18 65.2 0.1 7.1e-18 65.0 0.1 1.0 1 0 0 1 1 1 1 ParE toxin of type II toxin-antitoxin system, parDE PDDEXK_5 PF11645.8 CDL00283.1 - 3e-09 37.0 0.0 4.2e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 PD-(D/E)XK endonuclease N6_N4_Mtase PF01555.18 CDL00284.1 - 2.2e-21 76.6 0.0 5e-20 72.2 0.0 2.1 1 1 0 1 1 1 1 DNA methylase ParBc PF02195.18 CDL00284.1 - 2e-10 40.8 0.0 4.7e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 ParB-like nuclease domain Cons_hypoth95 PF03602.15 CDL00284.1 - 0.12 12.0 0.0 0.34 10.5 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical protein 95 N6_N4_Mtase PF01555.18 CDL00285.1 - 4e-15 56.1 0.0 1e-14 54.9 0.0 1.6 1 1 0 1 1 1 1 DNA methylase ParBc PF02195.18 CDL00285.1 - 1.6e-13 50.7 0.0 3.9e-13 49.5 0.0 1.7 1 0 0 1 1 1 1 ParB-like nuclease domain DNA_methylase PF00145.17 CDL00286.1 - 1e-10 41.5 0.0 1.1e-10 41.4 0.0 1.0 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase DDE_3 PF13358.6 CDL00287.1 - 2.1e-37 128.1 0.0 2.4e-37 127.9 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL00287.1 - 0.085 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain DUF2924 PF11149.8 CDL00288.1 - 5.4e-53 179.0 0.0 6.1e-53 178.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2924) RAMA PF18755.1 CDL00288.1 - 0.089 13.2 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Restriction Enzyme Adenine Methylase Associated Resolvase PF00239.21 CDL00289.1 - 1.6e-37 128.8 0.0 2.9e-37 128.0 0.0 1.4 1 0 0 1 1 1 1 Resolvase, N terminal domain Zn_ribbon_recom PF13408.6 CDL00289.1 - 5.5e-15 55.6 1.0 1e-14 54.8 1.0 1.5 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain Recombinase PF07508.13 CDL00289.1 - 5.6e-12 46.0 0.0 1e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Recombinase Ogr_Delta PF04606.12 CDL00289.1 - 0.19 11.7 2.3 0.39 10.7 2.3 1.6 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger SoPB_HTH PF18090.1 CDL00290.1 - 0.038 14.1 0.0 0.054 13.6 0.0 1.2 1 0 0 1 1 1 0 Centromere-binding protein HTH domain Lac_bphage_repr PF06543.12 CDL00293.1 - 0.087 12.8 0.1 0.093 12.7 0.1 1.1 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor EAL PF00563.20 CDL00294.1 - 2e-72 243.6 0.0 4.9e-72 242.3 0.0 1.7 1 0 0 1 1 1 1 EAL domain CheB_methylest PF01339.17 CDL00294.1 - 1.2e-58 197.6 0.0 2.3e-58 196.6 0.0 1.5 1 0 0 1 1 1 1 CheB methylesterase GGDEF PF00990.21 CDL00294.1 - 1.3e-53 181.0 0.4 4.9e-53 179.2 0.4 2.1 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain CheR PF01739.18 CDL00294.1 - 5.7e-50 169.5 0.0 9.8e-50 168.8 0.0 1.4 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain PAS_9 PF13426.7 CDL00294.1 - 4.6e-27 94.3 0.2 7e-19 68.0 0.1 3.0 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 CDL00294.1 - 9e-25 87.1 0.1 2.6e-12 46.9 0.0 4.7 5 0 0 5 5 4 2 PAS fold PAS PF00989.25 CDL00294.1 - 1.8e-18 66.6 0.2 1.7e-11 44.1 0.0 3.6 3 0 0 3 3 3 2 PAS fold CheR_N PF03705.15 CDL00294.1 - 5.6e-14 51.6 0.2 1.8e-13 50.0 0.2 2.0 1 0 0 1 1 1 1 CheR methyltransferase, all-alpha domain PAS_8 PF13188.7 CDL00294.1 - 1.1e-11 44.5 0.1 5.1e-05 23.2 0.0 3.8 3 0 0 3 3 3 2 PAS domain PAS_3 PF08447.12 CDL00294.1 - 3.5e-11 43.2 0.5 3.9e-09 36.7 0.1 3.3 3 0 0 3 3 3 1 PAS fold Spc7 PF08317.11 CDL00294.1 - 4.5e-05 22.5 5.0 0.00011 21.2 5.0 1.6 1 0 0 1 1 1 1 Spc7 kinetochore protein PAS_7 PF12860.7 CDL00294.1 - 0.00063 19.9 1.1 7.2 6.8 0.0 4.9 4 1 0 4 4 4 0 PAS fold Fez1 PF06818.15 CDL00294.1 - 0.014 15.9 1.8 0.054 14.0 1.8 2.0 1 0 0 1 1 1 0 Fez1 Seryl_tRNA_N PF02403.22 CDL00294.1 - 0.047 13.9 6.3 0.15 12.3 6.3 1.9 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain OmpH PF03938.14 CDL00294.1 - 0.066 13.6 8.2 0.074 13.4 6.2 2.1 2 0 0 2 2 1 0 Outer membrane protein (OmpH-like) Tropomyosin PF00261.20 CDL00294.1 - 0.079 12.3 12.4 0.21 10.9 12.4 1.6 1 0 0 1 1 1 0 Tropomyosin DUF16 PF01519.16 CDL00294.1 - 0.12 12.9 3.6 0.39 11.2 3.6 1.9 1 0 0 1 1 1 0 Protein of unknown function DUF16 IFT57 PF10498.9 CDL00294.1 - 0.12 11.3 5.8 0.2 10.6 5.8 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF4855 PF16147.5 CDL00294.1 - 0.16 11.0 0.6 0.3 10.2 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4855) DUF2968 PF11180.8 CDL00294.1 - 0.36 10.4 8.3 0.77 9.4 8.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Rootletin PF15035.6 CDL00294.1 - 0.36 10.8 10.8 0.31 11.0 8.4 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion APG6_N PF17675.1 CDL00294.1 - 0.44 11.1 12.4 1.6 9.3 12.4 1.9 1 0 0 1 1 1 0 Apg6 coiled-coil region HMMR_N PF15905.5 CDL00294.1 - 0.49 9.8 8.5 1 8.7 8.5 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Atg14 PF10186.9 CDL00294.1 - 0.54 9.3 2.5 1.2 8.1 2.5 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF812 PF05667.11 CDL00294.1 - 0.59 8.9 8.3 1 8.2 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Fusion_gly PF00523.18 CDL00294.1 - 1.1 7.4 3.0 0.87 7.8 0.9 1.7 2 0 0 2 2 2 0 Fusion glycoprotein F0 Golgin_A5 PF09787.9 CDL00294.1 - 1.4 8.4 10.9 2.6 7.5 10.9 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 UPF0242 PF06785.11 CDL00294.1 - 1.4 8.9 7.6 3.4 7.7 7.6 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Sec20 PF03908.13 CDL00294.1 - 1.6 8.7 4.3 2.5 8.1 1.5 2.6 2 0 0 2 2 2 0 Sec20 DUF2203 PF09969.9 CDL00294.1 - 1.8 9.3 5.7 0.65 10.7 1.3 2.5 3 0 0 3 3 1 0 Uncharacterized conserved protein (DUF2203) UPF0449 PF15136.6 CDL00294.1 - 2.7 8.5 7.6 1 9.8 4.0 2.3 2 0 0 2 2 1 0 Uncharacterised protein family UPF0449 DUF1664 PF07889.12 CDL00294.1 - 4.2 7.4 6.0 1 9.4 1.3 2.5 4 0 0 4 4 1 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 CDL00294.1 - 8.5 5.6 8.3 2.2 7.6 4.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) PHY PF00360.20 CDL00295.1 - 6.3e-38 129.9 0.1 1e-37 129.2 0.1 1.3 1 0 0 1 1 1 1 Phytochrome region GAF PF01590.26 CDL00295.1 - 5.9e-16 59.3 0.0 1.4e-15 58.1 0.0 1.6 1 0 0 1 1 1 1 GAF domain PAS_2 PF08446.11 CDL00295.1 - 1.6e-10 41.6 0.0 3.3e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 PAS fold GAF_2 PF13185.6 CDL00295.1 - 0.039 14.2 0.0 0.13 12.6 0.0 1.9 2 0 0 2 2 2 0 GAF domain HATPase_c PF02518.26 CDL00299.1 - 5.3e-24 84.9 0.0 9.6e-24 84.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDL00299.1 - 1.8e-22 79.6 0.0 5.4e-22 78.1 0.0 1.8 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CDL00299.1 - 3.7e-20 71.7 0.1 1.4e-19 69.9 0.0 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 CDL00300.1 - 1.9e-27 95.7 0.0 3.3e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HD PF01966.22 CDL00300.1 - 1e-18 67.7 0.8 1.8e-18 66.9 0.1 1.7 2 0 0 2 2 2 1 HD domain HD_5 PF13487.6 CDL00300.1 - 4.4e-17 62.1 0.3 1.1e-16 60.8 0.3 1.7 1 0 0 1 1 1 1 HD domain Response_reg PF00072.24 CDL00301.1 - 4.5e-22 78.3 0.2 5.1e-22 78.2 0.2 1.0 1 0 0 1 1 1 1 Response regulator receiver domain GFO_IDH_MocA PF01408.22 CDL00301.1 - 0.0025 18.6 0.0 0.0033 18.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DUF3948 PF13134.6 CDL00302.1 - 0.13 11.9 0.5 0.13 11.9 0.5 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3948) CHASE PF03924.13 CDL00304.1 - 3.6e-36 124.9 0.0 7.2e-36 123.9 0.0 1.5 1 0 0 1 1 1 1 CHASE domain HATPase_c PF02518.26 CDL00304.1 - 1.7e-24 86.5 0.0 3e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_4 PF08448.10 CDL00304.1 - 6.2e-12 45.7 0.9 4e-05 23.8 0.3 2.9 2 0 0 2 2 2 2 PAS fold HisKA PF00512.25 CDL00304.1 - 7.7e-11 41.9 0.1 2.1e-10 40.4 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 CDL00304.1 - 5.5e-09 36.2 0.0 5.2e-07 29.9 0.0 2.7 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CDL00304.1 - 6e-08 32.9 0.0 6.3e-06 26.4 0.0 2.7 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 CDL00304.1 - 1.6e-06 28.1 0.0 0.0021 18.0 0.0 2.9 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 CDL00304.1 - 9.5e-05 22.3 0.0 0.054 13.5 0.0 2.8 2 0 0 2 2 2 2 PAS domain HATPase_c_5 PF14501.6 CDL00304.1 - 0.006 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 CDL00304.1 - 0.061 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_2 PF08269.11 CDL00305.1 - 2.1e-57 194.5 0.0 2.9e-57 194.1 0.0 1.0 1 0 0 1 1 1 1 Cache domain sCache_2 PF17200.4 CDL00305.1 - 4e-42 143.7 0.0 2.2e-31 108.8 0.0 2.1 1 1 1 2 2 2 2 Single Cache domain 2 Cache_3-Cache_2 PF17201.4 CDL00305.1 - 4.2e-12 46.0 0.0 3.7e-08 33.0 0.0 2.2 1 1 1 2 2 2 2 Cache 3/Cache 2 fusion domain PAS_7 PF12860.7 CDL00306.1 - 1.9e-25 89.3 0.0 2.5e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 PAS fold GerE PF00196.19 CDL00306.1 - 3.6e-17 61.7 0.0 5.5e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDL00306.1 - 6.8e-06 25.7 0.0 1.4e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_28 PF13518.6 CDL00306.1 - 0.0035 17.4 0.3 0.013 15.6 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDL00306.1 - 0.0039 16.9 0.9 0.0078 16.0 0.1 1.9 2 0 0 2 2 2 1 Homeodomain-like domain PAS_4 PF08448.10 CDL00306.1 - 0.0055 16.9 0.1 0.014 15.7 0.0 1.7 1 1 1 2 2 2 1 PAS fold HTH_10 PF04967.12 CDL00306.1 - 0.015 15.1 0.1 0.19 11.5 0.1 2.3 1 1 0 1 1 1 0 HTH DNA binding domain Sigma70_r4 PF04545.16 CDL00306.1 - 0.02 14.4 0.0 0.055 13.0 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 MLTR_LBD PF17765.1 CDL00306.1 - 0.11 12.7 0.6 0.23 11.6 0.2 1.8 2 1 0 2 2 2 0 MmyB-like transcription regulator ligand binding domain PAS_8 PF13188.7 CDL00306.1 - 0.15 12.2 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 PAS domain DJ-1_PfpI PF01965.24 CDL00307.1 - 1.7e-07 31.2 0.2 8e-07 29.0 0.2 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family Catalase_C PF18011.1 CDL00307.1 - 0.059 13.0 0.0 0.11 12.1 0.0 1.6 1 1 0 1 1 1 0 C-terminal domain found in long catalases Peptidase_M32 PF02074.15 CDL00308.1 - 1.3e-165 551.9 0.0 1.4e-165 551.7 0.0 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase Thr_synth_N PF14821.6 CDL00309.1 - 3.6e-28 97.6 0.0 1.1e-27 96.1 0.0 1.9 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 CDL00309.1 - 7.3e-21 74.8 0.0 3e-19 69.6 0.0 2.1 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M16 PF00675.20 CDL00310.1 - 1.2e-43 148.6 0.0 1.2e-42 145.4 0.0 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CDL00310.1 - 2.7e-41 141.6 0.0 4.9e-41 140.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain NUDIX PF00293.28 CDL00311.1 - 1.5e-19 70.3 0.0 2e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 CDL00311.1 - 0.00039 20.4 0.0 0.00054 19.9 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain HDV_ag PF01517.18 CDL00312.1 - 0.037 13.8 0.3 0.067 13.0 0.2 1.4 1 1 0 1 1 1 0 Hepatitis delta virus delta antigen DUF5631 PF18645.1 CDL00312.1 - 0.052 13.9 1.7 0.055 13.9 0.2 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5631) GAS PF13851.6 CDL00312.1 - 0.053 12.9 0.3 0.092 12.1 0.3 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding AIP3 PF03915.13 CDL00312.1 - 0.058 12.5 0.3 0.091 11.8 0.3 1.4 1 0 0 1 1 1 0 Actin interacting protein 3 Rep_fac-A_3 PF08661.11 CDL00312.1 - 0.13 12.6 1.2 0.23 11.8 0.3 1.8 2 1 0 2 2 2 0 Replication factor A protein 3 KELK PF15796.5 CDL00312.1 - 0.19 12.2 0.3 0.38 11.3 0.3 1.4 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase BLOC1_2 PF10046.9 CDL00312.1 - 0.24 11.7 3.2 0.18 12.1 1.2 1.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3584 PF12128.8 CDL00312.1 - 0.41 8.1 4.9 0.72 7.3 4.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF2564 PF10819.8 CDL00312.1 - 2.4 8.6 8.1 0.78 10.2 4.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) DEAD PF00270.29 CDL00314.1 - 2e-42 144.9 0.0 2.3e-41 141.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDL00314.1 - 1.1e-25 90.1 0.0 5.7e-25 87.8 0.0 2.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DbpA PF03880.15 CDL00314.1 - 6.6e-16 58.1 0.0 1.1e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 DbpA RNA binding domain ResIII PF04851.15 CDL00314.1 - 0.00074 19.6 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CDL00314.1 - 0.042 13.2 0.0 0.079 12.3 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 CDL00314.1 - 0.085 13.1 0.8 1.2 9.4 0.8 2.4 1 1 0 1 1 1 0 AAA domain IF3_C PF00707.22 CDL00315.1 - 9.9e-40 134.4 2.4 1.5e-39 133.8 2.4 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 CDL00315.1 - 1.2e-30 105.6 0.0 2.5e-30 104.6 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain Tubulin_3 PF14881.6 CDL00315.1 - 0.11 12.2 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain tRNA-synt_2b PF00587.25 CDL00316.1 - 1.3e-41 142.6 0.0 2e-41 141.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CDL00316.1 - 1.7e-20 73.0 0.7 4.2e-20 71.7 0.7 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 CDL00316.1 - 1.3e-13 50.8 0.0 2.4e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 CDL00316.1 - 9.4e-09 35.2 0.3 2.4e-08 33.9 0.1 1.9 2 0 0 2 2 2 1 TGS domain KIAA1328 PF15369.6 CDL00317.1 - 0.24 11.2 0.0 0.36 10.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 CreA PF05981.12 CDL00318.1 - 4.5e-57 191.7 0.1 5.6e-57 191.4 0.1 1.0 1 0 0 1 1 1 1 CreA protein DUF4254 PF14063.6 CDL00319.1 - 0.00059 19.7 0.1 0.19 11.6 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF4254) HAD_2 PF13419.6 CDL00319.1 - 0.11 12.5 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Glyco_transf_9 PF01075.17 CDL00320.1 - 9.5e-09 34.9 0.0 1.4e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) Glyco_transf_9 PF01075.17 CDL00321.1 - 3.3e-19 69.2 0.0 4.2e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) Fer4_3 PF12798.7 CDL00321.1 - 0.12 13.3 0.9 0.37 11.8 0.9 1.8 1 0 0 1 1 1 0 4Fe-4S binding domain Hydrolase_4 PF12146.8 CDL00324.1 - 4.6e-62 209.4 0.0 5.5e-62 209.1 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDL00324.1 - 6e-14 52.3 0.2 2.5e-10 40.4 0.6 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDL00324.1 - 5.2e-12 46.9 13.2 5.2e-12 46.9 13.2 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CDL00324.1 - 0.00014 22.0 0.6 0.00035 20.8 0.6 1.6 2 0 0 2 2 2 1 Thioesterase domain Esterase PF00756.20 CDL00324.1 - 0.00018 21.3 0.4 0.002 17.8 0.2 2.1 2 0 0 2 2 2 1 Putative esterase Lipase_3 PF01764.25 CDL00324.1 - 0.008 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Tannase PF07519.11 CDL00324.1 - 0.086 11.7 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Tannase and feruloyl esterase FSH1 PF03959.13 CDL00324.1 - 0.15 11.7 0.0 1.1 8.8 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase (FSH1) DLH PF01738.18 CDL00324.1 - 0.15 11.6 0.0 15 5.0 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CDL00324.1 - 0.19 11.2 0.2 15 5.0 0.1 3.0 3 1 0 3 3 3 0 Prolyl oligopeptidase family ABC_tran PF00005.27 CDL00325.1 - 1.9e-31 109.4 0.0 2.6e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDL00325.1 - 6.6e-13 49.1 0.9 6.7e-07 29.4 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDL00325.1 - 1.2e-05 24.9 0.0 0.058 12.8 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDL00325.1 - 0.0007 19.3 0.1 0.0014 18.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDL00325.1 - 0.0028 18.2 0.1 0.0042 17.6 0.1 1.2 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDL00325.1 - 0.0049 16.8 0.0 0.012 15.5 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase DUF4162 PF13732.6 CDL00325.1 - 0.01 16.5 0.0 0.023 15.4 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4162) AAA_25 PF13481.6 CDL00325.1 - 0.018 14.6 0.7 0.14 11.7 0.0 2.6 2 1 2 4 4 4 0 AAA domain AAA_22 PF13401.6 CDL00325.1 - 0.021 15.1 0.0 0.046 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CDL00325.1 - 0.027 14.5 0.1 0.099 12.7 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CDL00325.1 - 0.04 14.3 0.0 0.1 13.0 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_15 PF13175.6 CDL00325.1 - 0.042 13.6 0.0 0.48 10.1 0.1 2.0 1 1 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 CDL00325.1 - 0.079 12.7 0.4 3.8 7.2 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CDL00325.1 - 0.12 12.0 1.2 0.94 9.2 0.7 2.3 1 1 1 2 2 2 0 AAA domain zf-CHCC PF10276.9 CDL00326.1 - 2e-17 62.9 2.0 2.8e-17 62.5 2.0 1.2 1 0 0 1 1 1 1 Zinc-finger domain zf-C2HC_2 PF13913.6 CDL00326.1 - 0.11 12.4 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type DNA_pol_A PF00476.20 CDL00327.1 - 1.5e-141 471.8 0.0 2e-141 471.5 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family A 5_3_exonuc_N PF02739.16 CDL00327.1 - 4e-57 192.6 0.0 6.4e-57 191.9 0.0 1.3 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain DNA_pol_A_exo1 PF01612.20 CDL00327.1 - 2e-34 118.8 0.0 3.5e-34 118.0 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease 5_3_exonuc PF01367.20 CDL00327.1 - 2.4e-30 105.0 0.0 5.3e-30 103.9 0.0 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.7 CDL00327.1 - 0.093 12.8 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif NYN_YacP PF05991.11 CDL00327.1 - 0.25 11.3 1.0 0.32 10.9 0.1 1.6 2 0 0 2 2 2 0 YacP-like NYN domain Cep57_CLD_2 PF14197.6 CDL00329.1 - 0.082 13.0 3.8 0.25 11.5 3.6 1.9 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 Acetyltransf_1 PF00583.25 CDL00330.1 - 4.7e-12 46.2 0.0 5.3e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDL00330.1 - 1.4e-08 35.1 0.0 1.7e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDL00330.1 - 4.5e-07 29.8 0.0 4.5e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDL00330.1 - 6.8e-07 29.2 0.0 1.1e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CDL00330.1 - 0.1 12.7 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 CDL00330.1 - 0.13 12.4 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Peptidase_M22 PF00814.25 CDL00331.1 - 1.1e-18 67.9 0.4 1.8e-18 67.2 0.4 1.3 1 0 0 1 1 1 1 Glycoprotease family Peptidase_M15 PF01427.17 CDL00332.1 - 1.1e-36 126.5 0.1 2.2e-36 125.5 0.1 1.4 1 1 0 1 1 1 1 D-ala-D-ala dipeptidase VanY PF02557.17 CDL00332.1 - 0.00051 19.9 0.3 0.0019 18.0 0.3 1.9 1 1 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Peptidase_M15_4 PF13539.6 CDL00332.1 - 0.07 13.7 0.4 0.37 11.3 0.4 2.2 1 1 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase HTH_1 PF00126.27 CDL00334.1 - 5.7e-22 77.4 0.3 5.7e-22 77.4 0.3 1.8 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CDL00334.1 - 6.2e-18 64.9 1.5 5.7e-17 61.8 1.5 2.2 1 1 0 1 1 1 1 LysR substrate binding domain HTH_30 PF13556.6 CDL00334.1 - 0.0016 18.2 0.0 0.0034 17.2 0.0 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_20 PF12840.7 CDL00334.1 - 0.017 15.2 0.1 0.14 12.3 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.6 CDL00334.1 - 0.032 13.8 0.0 0.086 12.4 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 CDL00334.1 - 0.052 13.5 1.3 0.099 12.6 0.0 2.1 3 0 0 3 3 3 0 HTH domain HTH_AsnC-type PF13404.6 CDL00334.1 - 0.085 12.7 0.1 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Ribosomal_S30AE PF02482.19 CDL00335.1 - 1e-18 67.9 0.7 1.2e-18 67.7 0.7 1.0 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein HSP90 PF00183.18 CDL00336.1 - 4.7e-125 418.4 0.0 4.2e-122 408.7 0.0 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 CDL00336.1 - 6.2e-13 48.7 0.2 1.3e-12 47.7 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDL00336.1 - 2.4e-11 44.1 0.1 4.1e-11 43.4 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CarD_CdnL_TRCF PF02559.16 CDL00338.1 - 1.8e-19 70.3 0.0 2.6e-19 69.7 0.0 1.2 1 0 0 1 1 1 1 CarD-like/TRCF domain DUF3470 PF11953.8 CDL00339.1 - 8.9e-18 64.0 3.0 1.4e-17 63.4 3.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3470) Fer4 PF00037.27 CDL00339.1 - 4.1e-09 35.9 25.3 4e-07 29.6 7.5 3.1 2 1 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 CDL00339.1 - 6.2e-08 32.7 24.4 0.00012 22.1 15.4 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDL00339.1 - 9.5e-08 32.0 9.0 7e-05 22.9 0.3 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDL00339.1 - 5.7e-07 30.4 8.9 0.00022 22.1 0.6 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_2 PF12797.7 CDL00339.1 - 8.5e-07 28.7 14.2 0.0018 18.3 3.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 CDL00339.1 - 1.7e-06 27.8 19.6 0.0001 22.2 5.2 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 CDL00339.1 - 3.3e-06 27.1 12.1 0.0015 18.6 0.6 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDL00339.1 - 4.9e-06 27.0 15.9 3.7e-05 24.2 16.2 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDL00339.1 - 9.4e-05 22.8 7.5 0.0036 17.7 0.1 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_4 PF12800.7 CDL00339.1 - 0.00016 21.9 15.9 0.001 19.4 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 CDL00339.1 - 0.00098 19.6 13.2 0.0029 18.1 0.9 2.2 1 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_15 PF13459.6 CDL00339.1 - 0.0073 17.0 5.6 0.02 15.6 0.2 2.3 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_13 PF13370.6 CDL00339.1 - 0.017 15.6 12.1 0.032 14.8 1.5 2.4 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_11 PF13247.6 CDL00339.1 - 0.2 11.8 9.8 1.2 9.3 9.7 1.9 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDL00339.1 - 2.2 9.4 20.4 0.84 10.7 7.5 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_20 PF14691.6 CDL00339.1 - 2.8 7.8 14.2 0.24 11.2 3.9 2.1 1 1 1 2 2 2 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster ETF_QO PF05187.13 CDL00339.1 - 3.7 7.7 8.9 0.88 9.7 2.3 2.1 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S TerC PF03741.16 CDL00340.1 - 7.4e-45 152.8 11.7 9.7e-45 152.5 11.7 1.1 1 0 0 1 1 1 1 Integral membrane protein TerC family Methyltransf_4 PF02390.17 CDL00341.1 - 4.8e-34 117.3 0.0 5.8e-34 117.0 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase S-AdoMet_synt_C PF02773.16 CDL00342.1 - 2.1e-64 215.7 0.0 9e-64 213.6 0.0 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CDL00342.1 - 5.9e-38 129.8 0.0 1.8e-37 128.3 0.0 1.8 2 1 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CDL00342.1 - 4.4e-37 126.8 0.1 8.7e-37 125.8 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain HTH_3 PF01381.22 CDL00344.1 - 7.3e-12 45.2 0.2 1.5e-11 44.2 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 CDL00344.1 - 1.1e-09 38.5 0.3 2e-09 37.6 0.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CDL00344.1 - 9.1e-06 25.6 0.0 1.5e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Pou PF00157.17 CDL00344.1 - 0.07 13.1 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Pou domain - N-terminal to homeobox domain HTH_26 PF13443.6 CDL00344.1 - 0.12 12.9 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain CN_hydrolase PF00795.22 CDL00345.1 - 1.2e-25 90.3 0.0 1.7e-25 89.8 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF4131 PF13567.6 CDL00345.1 - 0.0095 15.6 2.1 0.0095 15.6 2.1 4.3 4 1 0 4 4 4 1 Domain of unknown function (DUF4131) CorC_HlyC PF03471.17 CDL00346.1 - 9.9e-17 60.7 1.9 1.1e-16 60.6 0.1 1.9 2 0 0 2 2 2 1 Transporter associated domain CBS PF00571.28 CDL00346.1 - 4.2e-07 30.3 15.2 0.0024 18.3 0.4 3.8 3 1 1 4 4 4 3 CBS domain UPF0054 PF02130.17 CDL00347.1 - 1e-33 115.9 0.0 1.2e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 TEX19 PF15553.6 CDL00347.1 - 0.046 13.7 0.1 10 6.1 0.0 2.2 2 0 0 2 2 2 0 Testis-expressed protein 19 PhoH PF02562.16 CDL00348.1 - 1.8e-90 301.9 0.0 2.2e-90 301.6 0.0 1.1 1 0 0 1 1 1 1 PhoH-like protein AAA_30 PF13604.6 CDL00348.1 - 2.7e-07 30.5 0.1 6.7e-07 29.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CDL00348.1 - 2.3e-06 28.0 0.0 7.9e-06 26.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 CDL00348.1 - 4.3e-05 23.2 0.0 0.072 12.6 0.0 2.2 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain IstB_IS21 PF01695.17 CDL00348.1 - 0.026 14.3 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 CDL00348.1 - 0.036 14.3 0.0 7.7 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDL00348.1 - 0.042 13.4 0.2 0.15 11.6 0.0 2.0 3 0 0 3 3 3 0 AAA domain Zot PF05707.12 CDL00348.1 - 0.045 13.4 0.0 8 6.1 0.0 2.5 3 0 0 3 3 3 0 Zonular occludens toxin (Zot) DEAD PF00270.29 CDL00348.1 - 0.056 13.2 0.0 4.4 7.0 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA PF00004.29 CDL00348.1 - 0.15 12.5 0.6 0.57 10.6 0.4 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) UPF0004 PF00919.20 CDL00349.1 - 9.1e-30 102.6 0.0 1.6e-29 101.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 CDL00349.1 - 4.2e-27 95.6 0.0 9.5e-27 94.4 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily TRAM PF01938.20 CDL00349.1 - 8.5e-07 28.9 0.0 1.5e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 TRAM domain TRAM_2 PF18693.1 CDL00349.1 - 0.011 15.9 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 0 TRAM domain Acyltransferase PF01553.21 CDL00350.1 - 5.5e-22 77.8 0.0 8.6e-22 77.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acetyltransf_5 PF13444.6 CDL00351.1 - 5e-33 113.8 0.0 7.5e-33 113.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FUR PF01475.19 CDL00352.1 - 1.1e-41 141.8 0.1 1.2e-41 141.6 0.1 1.0 1 0 0 1 1 1 1 Ferric uptake regulator family RepL PF05732.11 CDL00352.1 - 0.0052 16.2 0.0 0.019 14.4 0.0 1.7 2 0 0 2 2 2 1 Firmicute plasmid replication protein (RepL) HTH_29 PF13551.6 CDL00352.1 - 0.038 14.0 0.1 0.083 12.9 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn helix TPR_14 PF13428.6 CDL00352.1 - 0.073 13.9 0.1 0.32 11.9 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat HTH_28 PF13518.6 CDL00352.1 - 0.08 13.1 0.4 0.78 9.9 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 CDL00352.1 - 0.13 12.1 0.4 1.4 8.8 0.1 2.5 2 0 0 2 2 2 0 Homeodomain-like domain ROS_MUCR PF05443.11 CDL00353.1 - 9e-51 171.1 0.0 1e-50 171.0 0.0 1.0 1 0 0 1 1 1 1 ROS/MUCR transcriptional regulator protein TusA PF01206.17 CDL00354.1 - 5.5e-15 55.0 0.0 6.3e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 Sulfurtransferase TusA Response_reg PF00072.24 CDL00356.1 - 7.1e-06 26.2 0.0 8.3e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Ppx-GppA PF02541.16 CDL00356.1 - 0.037 13.5 0.0 0.052 13.0 0.0 1.1 1 0 0 1 1 1 0 Ppx/GppA phosphatase family Hpt PF01627.23 CDL00357.1 - 0.00015 22.0 0.0 0.00031 20.9 0.0 1.6 1 1 0 1 1 1 1 Hpt domain Trypsin_2 PF13365.6 CDL00358.1 - 7.3e-35 121.1 1.8 1.2e-34 120.3 1.8 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 CDL00358.1 - 8.1e-24 83.8 0.5 8.8e-14 51.6 0.0 3.1 3 1 1 4 4 4 2 PDZ domain PDZ PF00595.24 CDL00358.1 - 2.7e-17 62.9 1.2 1.7e-06 28.3 0.0 3.5 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 CDL00358.1 - 8.3e-17 60.8 3.0 9.6e-09 35.0 0.0 3.5 3 0 0 3 3 3 2 PDZ domain Trypsin PF00089.26 CDL00358.1 - 2.6e-16 60.1 0.1 5.8e-16 59.0 0.1 1.5 1 1 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.6 CDL00358.1 - 7.8e-05 22.6 0.0 0.4 10.7 0.0 2.9 2 0 0 2 2 2 2 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 CDL00358.1 - 0.00034 19.4 1.0 0.038 12.6 0.0 2.2 2 0 0 2 2 2 2 Peptidase S46 TrkA_C PF02080.21 CDL00358.1 - 0.0028 17.5 1.4 2.3 8.1 0.2 3.0 3 0 0 3 3 3 2 TrkA-C domain Peptidase_S32 PF05579.13 CDL00358.1 - 0.022 13.9 0.6 1.7 7.8 0.4 2.2 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 MgsA_C PF12002.8 CDL00359.1 - 9.1e-70 233.9 0.0 1.3e-69 233.4 0.0 1.2 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 CDL00359.1 - 8.9e-19 67.6 0.1 3.2e-18 65.8 0.0 2.0 2 0 0 2 2 1 1 AAA C-terminal domain AAA PF00004.29 CDL00359.1 - 3e-13 50.3 0.0 5.3e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDL00359.1 - 1.5e-10 41.1 0.0 3.1e-10 40.0 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 CDL00359.1 - 2.9e-06 27.1 0.0 0.0022 17.7 0.0 2.3 1 1 1 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.14 CDL00359.1 - 3e-06 27.3 0.0 0.00018 21.5 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDL00359.1 - 1e-05 26.0 0.9 0.0013 19.2 0.0 3.0 1 1 2 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CDL00359.1 - 5.9e-05 23.4 0.0 0.0029 17.9 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 CDL00359.1 - 7.8e-05 23.2 0.0 0.00017 22.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDL00359.1 - 0.00022 20.7 0.1 0.026 13.9 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 CDL00359.1 - 0.00037 20.6 0.0 0.00071 19.7 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_30 PF13604.6 CDL00359.1 - 0.0034 17.1 0.1 3.7 7.2 0.0 2.7 1 1 0 2 2 2 2 AAA domain AAA_14 PF13173.6 CDL00359.1 - 0.0041 17.1 0.0 0.0081 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDL00359.1 - 0.0069 16.6 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 CDL00359.1 - 0.017 15.5 0.0 0.032 14.6 0.0 1.4 1 0 0 1 1 1 0 RNA helicase SKI PF01202.22 CDL00359.1 - 0.018 15.2 0.0 0.098 12.8 0.0 2.1 3 0 0 3 3 2 0 Shikimate kinase AAA_3 PF07726.11 CDL00359.1 - 0.029 14.2 0.0 0.11 12.4 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CDL00359.1 - 0.035 14.3 0.0 0.091 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDL00359.1 - 0.044 13.4 0.1 0.15 11.6 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDL00359.1 - 0.047 13.4 0.0 0.078 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDL00359.1 - 0.058 13.9 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Zeta_toxin PF06414.12 CDL00359.1 - 0.075 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Viral_helicase1 PF01443.18 CDL00359.1 - 0.081 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 CDL00359.1 - 0.088 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ResIII PF04851.15 CDL00359.1 - 0.093 12.7 0.0 15 5.6 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CDL00359.1 - 0.11 12.9 0.0 4.2 7.7 0.1 2.3 1 1 1 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CDL00359.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TsaE PF02367.17 CDL00359.1 - 0.17 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CCP_MauG PF03150.14 CDL00360.1 - 6.4e-58 195.7 0.0 1.8e-52 178.0 0.0 2.1 2 0 0 2 2 2 2 Di-haem cytochrome c peroxidase Cytochrom_C PF00034.21 CDL00360.1 - 3.3e-13 50.6 0.0 1.7e-09 38.7 0.0 2.4 2 0 0 2 2 2 2 Cytochrome c Cytochrome_CBB3 PF13442.6 CDL00360.1 - 0.00091 19.5 2.6 0.6 10.5 1.0 2.9 2 1 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III Cytochrome_C7 PF14522.6 CDL00360.1 - 0.0049 16.8 0.0 1.2 9.1 0.0 2.3 2 0 0 2 2 2 2 Cytochrome c7 and related cytochrome c DHOR PF06537.11 CDL00360.1 - 0.0062 15.2 0.2 0.35 9.4 0.0 2.5 3 0 0 3 3 3 1 Di-haem oxidoreductase, putative peroxidase Paired_CXXCH_1 PF09699.10 CDL00360.1 - 0.0084 15.8 0.3 2.1 8.2 0.0 2.4 2 0 0 2 2 2 2 Doubled CXXCH motif (Paired_CXXCH_1) DUF1924 PF09086.11 CDL00360.1 - 0.1 13.0 0.0 4.1 7.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1924) Cytochrom_C550 PF14495.6 CDL00360.1 - 0.1 12.3 0.1 0.52 10.0 0.0 2.1 2 0 0 2 2 2 0 Cytochrome c-550 domain HTH_Tnp_IS630 PF01710.16 CDL00361.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL00361.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL00361.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL00361.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL00361.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL00361.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDL00362.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL00362.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain Cytochrom_NNT PF03264.14 CDL00363.1 - 1.8e-70 236.1 7.1 4.3e-70 234.9 5.3 1.9 2 0 0 2 2 2 1 NapC/NirT cytochrome c family, N-terminal region Cytochrome_C7 PF14522.6 CDL00363.1 - 4.4e-07 29.8 14.9 0.00046 20.1 3.2 3.6 3 1 1 4 4 4 2 Cytochrome c7 and related cytochrome c Cytochrom_CIII PF02085.16 CDL00363.1 - 7.1e-06 26.3 12.0 0.0085 16.4 4.3 3.3 3 0 0 3 3 3 2 Class III cytochrome C family Cytochrom_c3_2 PF14537.6 CDL00363.1 - 7.3e-06 26.4 14.7 0.08 13.4 0.4 3.2 3 0 0 3 3 3 2 Cytochrome c3 Paired_CXXCH_1 PF09699.10 CDL00363.1 - 0.0012 18.5 19.3 0.031 14.0 2.9 4.3 3 1 2 5 5 5 3 Doubled CXXCH motif (Paired_CXXCH_1) DHC PF09626.10 CDL00363.1 - 0.028 15.3 16.9 0.36 11.7 0.8 4.6 3 1 1 4 4 4 0 Dihaem cytochrome c zf-ZPR1 PF03367.13 CDL00363.1 - 0.2 11.5 1.2 0.52 10.2 0.0 2.3 3 0 0 3 3 3 0 ZPR1 zinc-finger domain GF_recep_IV PF14843.6 CDL00363.1 - 0.76 9.6 6.6 1.3 8.8 1.6 2.9 3 0 0 3 3 3 0 Growth factor receptor domain IV Cytochrome_P460 PF16694.5 CDL00363.1 - 0.8 10.1 19.5 5.4 7.4 1.0 5.0 3 2 2 5 5 5 0 Cytochrome P460 DUF3365 PF11845.8 CDL00363.1 - 3.1 8.1 13.7 28 5.0 0.0 4.0 2 1 2 4 4 4 0 Protein of unknown function (DUF3365) FUR PF01475.19 CDL00364.1 - 5.1e-19 68.6 0.0 6.4e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Ferric uptake regulator family HTH_20 PF12840.7 CDL00364.1 - 0.034 14.2 0.1 0.064 13.3 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Penicillinase_R PF03965.16 CDL00364.1 - 0.15 12.4 0.0 0.19 12.1 0.0 1.1 1 0 0 1 1 1 0 Penicillinase repressor DUF2061 PF09834.9 CDL00365.1 - 2.9e-18 66.1 1.2 3.2e-18 65.9 1.2 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2061) CPSase_L_D2 PF02786.17 CDL00366.1 - 1.2e-82 276.6 0.1 1.9e-82 275.9 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CDL00366.1 - 2.3e-44 150.5 0.0 7.2e-44 148.8 0.1 1.9 2 0 0 2 2 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDL00366.1 - 1.9e-39 134.1 0.0 6.9e-39 132.3 0.0 1.9 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain PCC_BT PF18140.1 CDL00366.1 - 5.6e-29 101.1 0.0 1.1e-28 100.1 0.0 1.5 1 0 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain Biotin_lipoyl PF00364.22 CDL00366.1 - 1.6e-16 59.9 0.4 4.8e-16 58.4 0.4 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CDL00366.1 - 4.9e-08 32.7 0.0 1.1e-07 31.6 0.0 1.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 CDL00366.1 - 6.8e-06 25.8 0.0 2e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like ATP-grasp PF02222.22 CDL00366.1 - 2.5e-05 23.9 0.1 7.8e-05 22.3 0.1 1.9 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 CDL00366.1 - 0.00062 19.3 0.0 0.0019 17.7 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 CDL00366.1 - 0.0017 18.0 0.0 0.0063 16.1 0.0 1.8 2 0 0 2 2 2 1 RimK-like ATP-grasp domain GARS_A PF01071.19 CDL00366.1 - 0.0017 18.1 0.1 0.0036 17.1 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.14 CDL00366.1 - 0.0037 17.3 0.0 0.011 15.8 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain AP_endonuc_2 PF01261.24 CDL00366.1 - 0.041 13.3 0.1 0.33 10.4 0.0 2.2 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel QRPTase_N PF02749.16 CDL00366.1 - 0.065 13.3 0.0 0.2 11.7 0.0 1.8 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, N-terminal domain Bactofilin PF04519.13 CDL00366.1 - 0.088 13.1 0.1 0.31 11.4 0.0 2.0 2 0 0 2 2 1 0 Polymer-forming cytoskeletal Sacchrp_dh_NADP PF03435.18 CDL00366.1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GCV_H PF01597.19 CDL00366.1 - 0.12 12.2 0.1 0.27 11.1 0.1 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein Carboxyl_trans PF01039.22 CDL00367.1 - 7e-201 668.1 0.2 8e-201 668.0 0.2 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 CDL00367.1 - 0.0021 17.6 0.6 0.017 14.6 0.0 2.4 2 1 1 3 3 3 1 Malonate decarboxylase gamma subunit (MdcE) NUC130_3NT PF08158.12 CDL00367.1 - 0.17 12.2 0.2 0.37 11.2 0.2 1.5 1 0 0 1 1 1 0 NUC130/3NT domain ATP12 PF07542.11 CDL00368.1 - 3.5e-37 127.3 0.0 5.1e-37 126.8 0.0 1.2 1 0 0 1 1 1 1 ATP12 chaperone protein AsmA PF05170.14 CDL00369.1 - 9.9e-34 117.1 0.2 3e-18 66.0 0.0 2.2 2 0 0 2 2 2 2 AsmA family AsmA_2 PF13502.6 CDL00369.1 - 2.5e-14 53.4 4.6 2.5e-14 53.4 4.6 3.9 3 2 1 4 4 4 1 AsmA-like C-terminal region AsmA_1 PF13109.6 CDL00369.1 - 0.22 11.0 0.0 0.41 10.1 0.0 1.4 1 0 0 1 1 1 0 AsmA-like C-terminal region HAD_2 PF13419.6 CDL00370.1 - 5.1e-29 101.6 0.0 6.8e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDL00370.1 - 1.9e-18 67.5 0.0 7.1e-16 59.1 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDL00370.1 - 9.8e-14 52.2 0.1 1.4e-13 51.7 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDL00370.1 - 8.9e-12 44.9 0.7 2.2e-11 43.7 0.3 1.9 1 1 1 2 2 2 1 HAD-hyrolase-like Hydrolase_3 PF08282.12 CDL00370.1 - 6.7e-08 32.6 0.0 0.21 11.3 0.0 3.1 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDL00370.1 - 0.0057 16.7 0.0 0.11 12.6 0.0 2.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF2608 PF11019.8 CDL00370.1 - 0.083 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) Put_Phosphatase PF06888.12 CDL00370.1 - 0.12 11.8 0.0 15 4.9 0.1 2.9 2 1 1 3 3 3 0 Putative Phosphatase S6PP PF05116.13 CDL00370.1 - 0.12 11.9 0.1 3.6 7.1 0.0 2.5 3 0 0 3 3 3 0 Sucrose-6F-phosphate phosphohydrolase PNK3P PF08645.11 CDL00370.1 - 0.12 12.1 0.0 1.7 8.4 0.0 2.0 2 0 0 2 2 2 0 Polynucleotide kinase 3 phosphatase GntR PF00392.21 CDL00370.1 - 0.14 11.8 0.0 0.44 10.2 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family NIF PF03031.18 CDL00370.1 - 0.19 11.5 0.0 1.5 8.5 0.0 2.0 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase PepSY_2 PF13670.6 CDL00371.1 - 1.1 9.3 5.7 0.71 9.9 1.6 2.5 2 1 0 2 2 2 0 Peptidase propeptide and YPEB domain PseudoU_synth_2 PF00849.22 CDL00372.1 - 5e-35 121.0 0.0 6.8e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CDL00372.1 - 0.00039 20.1 0.0 0.00094 18.8 0.0 1.6 1 0 0 1 1 1 1 S4 domain NfeD PF01957.18 CDL00372.1 - 0.092 13.1 0.1 0.4 11.1 0.0 2.0 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding CRCB PF02537.15 CDL00373.1 - 2.7e-24 85.3 10.2 3.4e-24 85.0 10.2 1.1 1 0 0 1 1 1 1 CrcB-like protein, Camphor Resistance (CrcB) Phage_holin_3_3 PF16083.5 CDL00373.1 - 0.0031 17.6 4.6 0.0031 17.6 4.6 2.3 1 1 1 2 2 2 1 LydA holin phage, holin superfamily III DPBB_1 PF03330.18 CDL00374.1 - 1.5e-20 73.3 0.0 1.9e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 Lytic transglycolase DUF4176 PF13780.6 CDL00374.1 - 0.006 16.6 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4176) LRV PF01816.17 CDL00374.1 - 0.17 12.4 1.1 0.32 11.5 0.1 2.0 2 0 0 2 2 2 0 Leucine rich repeat variant Acylphosphatase PF00708.18 CDL00375.1 - 1.5e-24 86.2 0.0 1.7e-24 86.0 0.0 1.0 1 0 0 1 1 1 1 Acylphosphatase DUF5450 PF17529.2 CDL00375.1 - 0.097 12.8 0.1 0.12 12.5 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5450) SprA_N PF14349.6 CDL00375.1 - 0.16 10.8 0.0 0.18 10.6 0.0 1.0 1 0 0 1 1 1 0 Motility related/secretion protein Glyco_hydro_1 PF00232.18 CDL00376.1 - 8.3e-140 466.2 0.0 1e-139 465.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 TAT_signal PF10518.9 CDL00376.1 - 0.012 15.4 1.4 0.026 14.4 1.4 1.6 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence Cellulase PF00150.18 CDL00376.1 - 0.051 13.0 0.0 0.082 12.3 0.0 1.3 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Ribonuc_red_lgC PF02867.15 CDL00377.1 - 2.4e-139 465.3 0.0 4.8e-139 464.3 0.0 1.5 1 1 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 CDL00377.1 - 1.3e-09 37.9 0.0 3.5e-09 36.6 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain IBR PF01485.21 CDL00377.1 - 0.1 12.9 3.1 0.25 11.6 3.1 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain FMN_red PF03358.15 CDL00378.1 - 1.1e-43 148.6 0.0 1.5e-43 148.2 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CDL00378.1 - 1.3e-10 41.4 0.0 2.7e-10 40.3 0.0 1.5 1 1 1 2 2 2 1 Flavodoxin-like fold Gly-zipper_Omp PF13488.6 CDL00379.1 - 0.0035 17.3 5.9 0.14 12.2 0.4 2.3 2 0 0 2 2 2 2 Glycine zipper Rick_17kDa_Anti PF05433.15 CDL00379.1 - 0.12 12.2 0.7 0.12 12.2 0.7 2.2 2 0 0 2 2 2 0 Glycine zipper 2TM domain DUF1269 PF06897.12 CDL00379.1 - 3.2 8.1 9.3 0.24 11.7 2.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1269) Gly-zipper_YMGG PF13441.6 CDL00379.1 - 8.6 6.2 16.5 0.65 9.8 2.6 2.1 1 1 1 2 2 2 0 YMGG-like Gly-zipper DDE_3 PF13358.6 CDL00380.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL00380.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDL00381.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL00381.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL00381.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL00381.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL00381.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL00381.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain Coat_F PF07875.12 CDL00382.1 - 0.00012 22.2 0.2 0.0003 20.9 0.2 1.7 1 1 1 2 2 2 1 Coat F domain TetR_C_31 PF17940.1 CDL00382.1 - 0.0047 17.1 1.4 0.0069 16.6 1.3 1.4 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain Rubrerythrin PF02915.17 CDL00382.1 - 0.019 15.4 0.1 0.023 15.1 0.1 1.1 1 0 0 1 1 1 0 Rubrerythrin COQ7 PF03232.13 CDL00382.1 - 0.03 14.1 0.5 0.037 13.8 0.5 1.2 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 Galanin PF01296.18 CDL00382.1 - 0.066 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Galanin CSD PF00313.22 CDL00384.1 - 8.6e-22 76.8 0.0 9.3e-22 76.7 0.0 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CDL00384.1 - 0.00042 19.9 0.1 0.00051 19.7 0.1 1.2 1 0 0 1 1 1 1 Ribonuclease B OB domain S4 PF01479.25 CDL00385.1 - 6.7e-14 51.3 0.0 1.1e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 S4 domain Hexapep PF00132.24 CDL00386.1 - 8.7e-13 47.4 12.3 1.5e-06 27.6 0.8 3.8 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDL00386.1 - 2.3e-06 27.3 7.5 0.0031 17.2 0.9 3.3 2 1 1 3 3 3 3 Hexapeptide repeat of succinyl-transferase Aldedh PF00171.22 CDL00387.1 - 1.7e-36 125.8 0.4 3e-36 125.0 0.4 1.3 1 1 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CDL00387.1 - 0.079 12.0 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) ECH_1 PF00378.20 CDL00388.1 - 2.6e-69 233.3 0.2 3.3e-69 233.0 0.2 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDL00388.1 - 1.1e-36 127.1 0.7 1.3e-31 110.4 0.3 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CDL00389.1 - 6.4e-65 218.9 0.0 7.1e-65 218.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDL00389.1 - 2.6e-31 109.3 0.1 2.4e-29 102.9 0.0 1.9 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase 3HCDH_N PF02737.18 CDL00390.1 - 1e-58 198.2 0.4 1e-58 198.2 0.4 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CDL00390.1 - 1.6e-47 160.1 2.7 8.1e-28 96.9 0.1 3.4 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_RFF PF18321.1 CDL00390.1 - 1.2e-24 86.6 3.1 6e-24 84.3 0.9 3.0 2 0 0 2 2 2 1 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain NAD_binding_2 PF03446.15 CDL00390.1 - 0.00033 20.8 0.0 0.00094 19.4 0.0 1.8 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DAO PF01266.24 CDL00390.1 - 0.00087 19.0 2.2 0.0019 17.9 2.2 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 CDL00390.1 - 0.0017 17.7 0.2 0.0034 16.8 0.2 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 CDL00390.1 - 0.0048 17.1 2.6 0.018 15.2 2.6 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain F420_oxidored PF03807.17 CDL00390.1 - 0.0061 17.1 1.3 0.019 15.5 1.3 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 CDL00390.1 - 0.018 15.1 0.3 0.068 13.1 0.0 2.1 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rossmann-like PF10727.9 CDL00390.1 - 0.032 14.1 1.6 1 9.2 0.5 2.6 2 0 0 2 2 2 0 Rossmann-like domain ApbA PF02558.16 CDL00390.1 - 0.033 13.8 0.5 0.072 12.7 0.5 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA SWIRM-assoc_1 PF16495.5 CDL00390.1 - 0.3 11.1 1.4 0.4 10.7 0.0 1.9 2 0 0 2 2 2 0 SWIRM-associated region 1 HTH_IclR PF09339.10 CDL00390.1 - 3.7 7.4 6.4 14 5.6 0.4 3.7 4 0 0 4 4 4 0 IclR helix-turn-helix domain 4HBT PF03061.22 CDL00391.1 - 1.8e-12 47.4 0.3 3.2e-12 46.6 0.3 1.4 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 CDL00391.1 - 7.1e-05 22.9 0.0 0.00011 22.4 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4442) Flagellin_D3 PF08884.11 CDL00391.1 - 0.047 14.1 0.0 0.078 13.4 0.0 1.3 1 0 0 1 1 1 0 Flagellin D3 domain PS-DH PF14765.6 CDL00391.1 - 0.077 12.2 0.0 0.082 12.1 0.0 1.2 1 0 0 1 1 1 0 Polyketide synthase dehydratase Thiolase_N PF00108.23 CDL00392.1 - 1.2e-79 267.3 0.0 1.6e-79 267.0 0.0 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDL00392.1 - 3.2e-44 149.5 0.7 6.3e-44 148.6 0.7 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CDL00392.1 - 0.0011 18.6 0.2 0.0024 17.5 0.2 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding_C_2 PF14535.6 CDL00393.1 - 2.5e-25 88.6 0.0 5.3e-25 87.6 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 CDL00393.1 - 2.8e-16 59.2 0.8 3.7e-16 58.7 0.0 1.5 2 0 0 2 2 2 1 AMP-binding enzyme LuxE PF04443.12 CDL00393.1 - 0.002 17.2 0.0 0.65 9.0 0.0 2.1 2 0 0 2 2 2 2 Acyl-protein synthetase, LuxE GH3 PF03321.13 CDL00393.1 - 0.085 11.7 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 GH3 auxin-responsive promoter Aconitase_2_N PF06434.13 CDL00394.1 - 4.9e-95 317.0 0.0 7.2e-95 316.4 0.0 1.3 1 0 0 1 1 1 1 Aconitate hydratase 2 N-terminus Aconitase_B_N PF11791.8 CDL00394.1 - 1.6e-60 203.6 0.0 2.8e-60 202.8 0.0 1.4 1 0 0 1 1 1 1 Aconitate B N-terminal domain Aconitase PF00330.20 CDL00394.1 - 3.3e-40 138.5 0.0 1.8e-38 132.7 0.0 2.3 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Ketoacyl-synt_C PF02801.22 CDL00394.1 - 0.096 12.7 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain ABC_tran PF00005.27 CDL00395.1 - 2e-24 86.7 0.0 2.5e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDL00395.1 - 3.3e-09 37.0 0.2 0.00016 21.6 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDL00395.1 - 3.5e-09 36.4 0.0 9.7e-05 21.9 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDL00395.1 - 3.9e-05 23.3 0.1 0.00022 20.9 0.1 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDL00395.1 - 0.0022 18.4 0.3 0.0035 17.7 0.2 1.5 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 CDL00395.1 - 0.0023 17.3 0.2 0.0032 16.9 0.2 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 CDL00395.1 - 0.015 15.0 0.1 0.026 14.3 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDL00395.1 - 0.038 14.5 0.0 0.052 14.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CDL00395.1 - 0.049 13.3 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 CDL00395.1 - 0.053 13.5 0.2 0.11 12.5 0.2 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 CDL00395.1 - 0.066 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_27 PF13514.6 CDL00395.1 - 0.081 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain CcmB PF03379.13 CDL00396.1 - 4.6e-78 261.6 27.1 5.3e-78 261.4 27.1 1.0 1 0 0 1 1 1 1 CcmB protein ABC2_membrane PF01061.24 CDL00396.1 - 0.00014 21.4 11.4 0.0002 20.9 11.4 1.1 1 0 0 1 1 1 1 ABC-2 type transporter NapE PF06796.11 CDL00396.1 - 0.053 13.0 3.8 3.1 7.4 0.5 2.8 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE ABC2_membrane_3 PF12698.7 CDL00396.1 - 0.14 11.3 16.1 0.0099 15.0 10.8 1.6 1 1 1 2 2 2 0 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 CDL00396.1 - 2 7.6 19.6 2.9 7.1 18.2 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein Multi_Drug_Res PF00893.19 CDL00397.1 - 1.4e-25 89.7 5.8 1.9e-25 89.3 5.8 1.2 1 0 0 1 1 1 1 Small Multidrug Resistance protein Ilm1 PF10311.9 CDL00397.1 - 0.032 13.9 0.0 0.044 13.4 0.0 1.4 1 1 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 DUF3367 PF11847.8 CDL00397.1 - 0.52 8.1 4.9 0.31 8.8 3.5 1.4 1 1 1 2 2 2 0 Alpha-(1->3)-arabinofuranosyltransferase DUF948 PF06103.11 CDL00398.1 - 0.34 11.2 6.2 0.89 9.8 0.6 2.8 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) CxxCxxCC PF03692.15 CDL00400.1 - 8.8e-08 32.7 1.0 1.6e-07 31.9 1.0 1.4 1 0 0 1 1 1 1 Putative zinc- or iron-chelating domain Cytochrom_C_asm PF01578.20 CDL00401.1 - 7.5e-33 114.1 16.4 7.5e-33 114.1 16.4 1.3 2 0 0 2 2 2 1 Cytochrome C assembly protein DUF2070 PF09843.9 CDL00401.1 - 3.1 6.0 5.4 4.1 5.6 5.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) CcmD PF04995.14 CDL00402.1 - 2e-13 50.2 1.5 2e-13 50.2 1.5 1.7 1 1 1 2 2 2 1 Heme exporter protein D (CcmD) LPG_synthase_TM PF03706.13 CDL00402.1 - 0.0065 16.0 0.0 0.0069 16.0 0.0 1.0 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region CcmE PF03100.15 CDL00403.1 - 6.3e-45 152.3 0.0 7.3e-45 152.1 0.0 1.0 1 0 0 1 1 1 1 CcmE CcmF_C PF16327.5 CDL00404.1 - 1.3e-120 402.6 8.0 1.3e-120 402.6 8.0 2.4 2 0 0 2 2 2 1 Cytochrome c-type biogenesis protein CcmF C-terminal Cytochrom_C_asm PF01578.20 CDL00404.1 - 1.4e-52 178.6 13.8 4.5e-52 176.9 13.8 1.9 1 0 0 1 1 1 1 Cytochrome C assembly protein Redoxin PF08534.10 CDL00405.1 - 8.2e-10 38.6 0.0 1.7e-09 37.5 0.0 1.4 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CDL00405.1 - 4.6e-08 33.0 0.0 6.6e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.20 CDL00405.1 - 0.085 12.9 0.0 0.64 10.0 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin CcmH PF03918.14 CDL00406.1 - 9.3e-53 177.4 0.0 1.1e-52 177.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C biogenesis protein IN_DBD_C PF00552.21 CDL00406.1 - 0.061 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Integrase DNA binding domain Trp_oprn_chp PF09534.10 CDL00406.1 - 0.67 9.7 3.7 4.1 7.2 0.8 2.1 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) TPR_2 PF07719.17 CDL00407.1 - 2.7e-09 36.4 0.0 1.5e-05 24.7 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDL00407.1 - 4.3e-06 27.3 0.4 0.011 16.4 0.0 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDL00407.1 - 7.7e-06 25.5 0.1 7.5e-05 22.4 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDL00407.1 - 1.5e-05 25.0 0.2 0.012 15.9 0.0 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDL00407.1 - 1.8e-05 24.3 0.0 0.0032 17.1 0.0 2.4 2 0 0 2 2 2 1 TPR repeat TPR_19 PF14559.6 CDL00407.1 - 1.8e-05 25.1 0.1 0.97 10.0 0.0 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDL00407.1 - 2.3e-05 24.7 0.4 0.075 13.7 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDL00407.1 - 0.00016 22.2 5.5 0.0019 18.9 0.1 4.0 3 3 2 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDL00407.1 - 0.00043 20.3 0.0 0.0017 18.4 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDL00407.1 - 0.0015 17.8 0.0 0.0025 17.1 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat BTAD PF03704.17 CDL00407.1 - 0.0067 16.9 0.8 0.017 15.6 0.0 2.0 3 0 0 3 3 3 1 Bacterial transcriptional activator domain TPR_7 PF13176.6 CDL00407.1 - 0.061 13.4 0.3 1.4 9.1 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDL00407.1 - 0.061 13.6 0.0 0.82 10.0 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DDE_3 PF13358.6 CDL00408.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL00408.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDL00409.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL00409.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL00409.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL00409.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL00409.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL00409.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain GTP_EFTU PF00009.27 CDL00410.1 - 3.8e-53 179.9 0.0 5.4e-53 179.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CDL00410.1 - 1.3e-19 70.1 0.0 2.6e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDL00410.1 - 5.1e-08 33.2 1.0 2.7e-07 30.9 0.5 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDL00410.1 - 2.2e-06 27.7 0.1 4.2e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 CDL00410.1 - 0.002 17.5 0.1 0.0033 16.7 0.1 1.2 1 0 0 1 1 1 1 Septin AIG1 PF04548.16 CDL00410.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 AIG1 family PfkB PF00294.24 CDL00411.1 - 8.9e-48 163.1 2.0 1.2e-47 162.7 2.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase EI24 PF07264.11 CDL00412.1 - 1.5e-21 77.4 20.4 2e-21 77.0 20.4 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) PM0188 PF11477.8 CDL00413.1 - 0.1 11.8 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Sialyltransferase PMO188 Glucosaminidase PF01832.20 CDL00414.1 - 1.7e-17 63.7 0.0 2.8e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase DUF2537 PF10801.8 CDL00414.1 - 0.017 15.4 0.2 0.036 14.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2537) MLTR_LBD PF17765.1 CDL00414.1 - 0.046 13.8 2.7 0.19 11.8 0.2 2.2 2 0 0 2 2 2 0 MmyB-like transcription regulator ligand binding domain NifU PF01106.17 CDL00415.1 - 1.3e-30 105.4 0.0 1.8e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 CDL00415.1 - 2.1e-30 104.6 0.0 4e-30 103.7 0.0 1.5 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal Usp PF00582.26 CDL00416.1 - 4.6e-12 46.6 0.0 5.1e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family DNA_photolyase PF00875.18 CDL00416.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.1 1 0 0 1 1 1 0 DNA photolyase DUF3088 PF11287.8 CDL00416.1 - 0.13 12.0 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3088) Alph_Pro_TM PF09608.10 CDL00417.1 - 3.2e-81 272.5 0.1 3.8e-81 272.2 0.1 1.1 1 0 0 1 1 1 1 Putative transmembrane protein (Alph_Pro_TM) TcfC PF16967.5 CDL00417.1 - 0.14 11.6 0.1 0.35 10.4 0.1 1.6 1 0 0 1 1 1 0 E-set like domain TauE PF01925.19 CDL00418.1 - 6.7e-50 169.9 41.9 8.2e-50 169.6 41.9 1.1 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE EMP70 PF02990.16 CDL00418.1 - 0.011 14.5 0.6 0.011 14.5 0.6 2.1 2 0 0 2 2 2 0 Endomembrane protein 70 DUF2076 PF09849.9 CDL00418.1 - 0.24 11.4 0.2 0.24 11.4 0.2 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF2333 PF10095.9 CDL00419.1 - 7.7e-11 41.6 0.4 1.1e-05 24.7 0.0 2.1 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2333) PCB_OB PF17092.5 CDL00419.1 - 0.059 14.1 0.0 9.2 7.1 0.0 2.3 2 0 0 2 2 2 0 Penicillin-binding protein OB-like domain GST_C_2 PF13410.6 CDL00419.1 - 1 9.4 4.9 9.1 6.4 1.0 3.3 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain tRNA-synt_1b PF00579.25 CDL00420.1 - 3.4e-76 256.4 0.0 4.2e-76 256.1 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) MurJ PF03023.14 CDL00421.1 - 4.1e-114 381.7 27.2 5e-114 381.4 27.2 1.0 1 0 0 1 1 1 1 Lipid II flippase MurJ Polysacc_synt_C PF14667.6 CDL00421.1 - 8.8e-13 48.5 12.5 8.8e-13 48.5 12.5 3.8 2 1 2 4 4 4 1 Polysaccharide biosynthesis C-terminal domain MatE PF01554.18 CDL00421.1 - 6e-08 32.5 9.5 6e-08 32.5 9.5 4.2 5 2 0 5 5 5 2 MatE GlnD_UR_UTase PF08335.11 CDL00422.1 - 9.6e-37 126.3 0.1 2.2e-36 125.2 0.1 1.6 1 0 0 1 1 1 1 GlnD PII-uridylyltransferase ACT_6 PF13740.6 CDL00422.1 - 9.9e-11 41.5 0.2 0.00043 20.2 0.1 2.7 2 0 0 2 2 2 2 ACT domain HD PF01966.22 CDL00422.1 - 1.5e-10 41.4 0.1 2.7e-09 37.3 0.1 3.0 2 2 0 2 2 2 1 HD domain ACT PF01842.25 CDL00422.1 - 9.8e-10 38.0 0.1 0.00019 21.1 0.0 3.2 3 0 0 3 3 3 2 ACT domain ACT_4 PF13291.6 CDL00422.1 - 5.5e-08 33.3 0.0 0.0081 16.7 0.0 3.0 2 0 0 2 2 2 2 ACT domain NTP_transf_2 PF01909.23 CDL00422.1 - 5.5e-05 23.4 0.0 0.00012 22.3 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain GlnE PF03710.15 CDL00422.1 - 0.0069 15.8 0.0 0.016 14.6 0.0 1.6 1 0 0 1 1 1 1 Glutamate-ammonia ligase adenylyltransferase Skp1_POZ PF03931.15 CDL00422.1 - 0.13 12.4 0.0 0.4 10.9 0.0 1.8 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain MutS_V PF00488.21 CDL00424.1 - 1.8e-83 279.2 0.0 2.8e-83 278.6 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 CDL00424.1 - 2.7e-40 137.1 0.0 5e-40 136.3 0.0 1.5 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 CDL00424.1 - 6.8e-40 137.3 0.7 1.4e-39 136.3 0.7 1.6 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 CDL00424.1 - 1e-22 80.3 0.1 1.8e-22 79.5 0.1 1.4 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 CDL00424.1 - 6.5e-17 62.1 0.0 1.5e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 MutS domain II AAA_29 PF13555.6 CDL00424.1 - 0.0074 16.0 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_27 PF13514.6 CDL00424.1 - 0.023 14.3 0.0 0.055 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDL00424.1 - 0.03 14.8 0.0 0.1 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain Hpt PF01627.23 CDL00424.1 - 0.034 14.4 2.3 0.12 12.7 1.1 2.6 2 0 0 2 2 2 0 Hpt domain YflT PF11181.8 CDL00425.1 - 0.0031 18.0 0.0 0.0071 16.8 0.0 1.6 2 0 0 2 2 2 1 Heat induced stress protein YflT DUF3341 PF11821.8 CDL00425.1 - 0.0046 16.6 0.0 2.7 7.6 0.0 2.2 2 1 0 2 2 2 2 Protein of unknown function (DUF3341) PTA_PTB PF01515.19 CDL00426.1 - 6.6e-87 291.8 0.0 1.2e-86 290.9 0.0 1.3 1 0 0 1 1 1 1 Phosphate acetyl/butaryl transferase malic PF00390.19 CDL00426.1 - 1.6e-29 103.0 0.0 1.6e-27 96.5 0.0 2.4 1 1 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.15 CDL00426.1 - 1.2e-22 80.5 3.0 3.9e-22 78.8 3.0 1.9 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain HATPase_c PF02518.26 CDL00427.1 - 3.4e-21 75.9 0.0 5.2e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDL00427.1 - 3.1e-17 62.4 2.0 7.3e-17 61.2 0.2 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 CDL00427.1 - 3.8e-05 23.6 0.1 0.00013 21.9 0.1 1.9 1 0 0 1 1 1 1 PAS domain HATPase_c_2 PF13581.6 CDL00427.1 - 0.0024 17.8 0.1 0.0045 16.9 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain PAS_4 PF08448.10 CDL00427.1 - 0.074 13.3 0.0 0.21 11.9 0.0 1.8 1 0 0 1 1 1 0 PAS fold PAS PF00989.25 CDL00427.1 - 0.13 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 PAS fold HATPase_c_5 PF14501.6 CDL00427.1 - 0.2 11.6 0.0 4.1 7.4 0.0 2.3 2 0 0 2 2 2 0 GHKL domain PAS_9 PF13426.7 CDL00427.1 - 0.21 11.8 0.0 0.68 10.2 0.0 1.8 2 0 0 2 2 2 0 PAS domain Zn_Tnp_IS1595 PF12760.7 CDL00428.1 - 0.12 12.4 2.0 0.27 11.2 2.0 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Zn_ribbon_recom PF13408.6 CDL00428.1 - 0.12 12.9 5.1 0.2 12.2 5.1 1.3 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Zn_ribbon_SprT PF17283.2 CDL00428.1 - 1.6 8.7 10.0 2.7 8.0 6.4 2.1 1 1 1 2 2 2 0 SprT-like zinc ribbon domain zf-RING_7 PF02591.15 CDL00428.1 - 7.9 6.8 10.8 27 5.1 0.1 3.5 3 1 0 3 3 3 0 C4-type zinc ribbon domain G_glu_transpept PF01019.21 CDL00429.1 - 1.7e-126 423.0 0.0 1.9e-126 422.8 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Pribosyltran PF00156.27 CDL00430.1 - 4.3e-15 55.6 0.2 6.6e-15 55.0 0.2 1.3 1 1 0 1 1 1 1 Phosphoribosyl transferase domain ATPgrasp_N PF18130.1 CDL00430.1 - 0.011 16.3 0.1 0.069 13.7 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp N-terminal domain RHH_5 PF07878.11 CDL00431.1 - 0.003 17.4 0.3 0.0053 16.6 0.2 1.5 2 0 0 2 2 2 1 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 DUF1263 PF06882.12 CDL00431.1 - 0.0086 16.1 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1263) RHH_1 PF01402.21 CDL00431.1 - 0.014 15.3 0.1 0.024 14.6 0.1 1.4 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family UBA_e1_thiolCys PF10585.9 CDL00431.1 - 0.11 12.4 0.0 0.11 12.4 0.0 1.0 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site Jag_N PF14804.6 CDL00431.1 - 0.15 12.4 1.0 0.24 11.7 0.0 1.7 2 0 0 2 2 2 0 Jag N-terminus Transgly PF00912.22 CDL00432.1 - 1.7e-60 203.5 0.0 2.7e-60 202.9 0.0 1.3 1 0 0 1 1 1 1 Transglycosylase Transpeptidase PF00905.22 CDL00432.1 - 1.4e-33 116.5 0.5 7.4e-33 114.0 0.5 1.9 1 1 0 1 1 1 1 Penicillin binding protein transpeptidase domain MFS_1 PF07690.16 CDL00434.1 - 2.3e-41 141.9 60.6 6.7e-39 133.8 26.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDL00434.1 - 9.7e-14 51.1 10.0 9.7e-14 51.1 10.0 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CDL00434.1 - 5.1e-07 28.5 1.5 8.3e-07 27.8 1.5 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 CDL00434.1 - 0.0026 16.2 28.0 0.0033 15.9 28.0 1.0 1 0 0 1 1 1 1 Transmembrane secretion effector DUF45 PF01863.17 CDL00435.1 - 1.3e-47 162.5 0.0 1.6e-47 162.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF45 Peptidase_M90 PF06167.12 CDL00435.1 - 0.092 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 CxxCxxCC PF03692.15 CDL00436.1 - 1.6e-08 35.1 7.6 2.7e-08 34.4 7.6 1.4 1 0 0 1 1 1 1 Putative zinc- or iron-chelating domain PHB_depo_C PF06850.11 CDL00437.1 - 1.6e-94 315.0 0.0 2.2e-94 314.6 0.0 1.2 1 0 0 1 1 1 1 PHB de-polymerase C-terminus DUF1072 PF06380.11 CDL00437.1 - 0.15 11.9 0.4 0.31 10.9 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1072) GATase_3 PF07685.14 CDL00438.1 - 5.8e-30 104.4 0.0 8.5e-30 103.8 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AAA_26 PF13500.6 CDL00438.1 - 6.4e-16 58.8 0.0 3.8e-09 36.6 0.0 2.9 3 0 0 3 3 3 2 AAA domain CbiA PF01656.23 CDL00438.1 - 5.6e-12 45.8 0.0 9.4e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 CDL00438.1 - 0.057 13.3 0.1 0.12 12.2 0.0 1.6 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B SCO1-SenC PF02630.14 CDL00439.1 - 1.7e-49 167.2 0.0 2e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 CDL00439.1 - 0.024 14.6 0.0 0.039 13.9 0.0 1.4 1 1 0 1 1 1 0 AhpC/TSA family DsbD_2 PF13386.6 CDL00440.1 - 2.4e-37 128.8 26.5 3.7e-37 128.2 26.5 1.2 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region SRTM1 PF15872.5 CDL00440.1 - 0.096 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 TP_methylase PF00590.20 CDL00441.1 - 1.6e-44 152.4 3.2 1.8e-44 152.2 3.2 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Radical_SAM PF04055.21 CDL00441.1 - 0.061 13.7 0.0 0.14 12.5 0.0 1.5 1 1 0 1 1 1 0 Radical SAM superfamily TP_methylase PF00590.20 CDL00442.1 - 2.7e-41 141.8 1.9 3.2e-41 141.6 1.9 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Radical_SAM PF04055.21 CDL00442.1 - 0.0086 16.5 0.0 0.012 16.0 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily TP_methylase PF00590.20 CDL00443.1 - 8.1e-33 114.2 1.2 8.1e-33 114.2 1.2 2.2 3 0 0 3 3 3 1 Tetrapyrrole (Corrin/Porphyrin) Methylases CbiG_C PF01890.16 CDL00443.1 - 3.6e-32 111.3 0.6 8.4e-32 110.2 0.6 1.7 1 0 0 1 1 1 1 Cobalamin synthesis G C-terminus CbiG_N PF11760.8 CDL00443.1 - 5.9e-28 96.7 1.8 1.6e-27 95.3 0.3 2.5 2 1 0 2 2 2 1 Cobalamin synthesis G N-terminal CbiG_mid PF11761.8 CDL00443.1 - 0.045 13.9 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 Cobalamin biosynthesis central region TP_methylase PF00590.20 CDL00444.1 - 2e-44 152.1 0.3 2.3e-44 151.9 0.3 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TP_methylase PF00590.20 CDL00445.1 - 5.4e-20 72.2 0.1 1.2e-19 71.1 0.1 1.6 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Methyltr_RsmB-F PF01189.17 CDL00445.1 - 0.0079 15.8 0.0 0.11 12.1 0.0 2.1 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 CDL00445.1 - 0.14 12.9 0.0 0.38 11.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CDL00445.1 - 0.18 11.6 0.0 0.39 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CbiC PF02570.15 CDL00446.1 - 1.4e-71 240.2 0.0 3.6e-71 238.9 0.4 1.5 2 0 0 2 2 2 1 Precorrin-8X methylmutase CbiX PF01903.17 CDL00447.1 - 7.3e-50 167.8 0.0 4.7e-25 88.0 0.0 2.2 2 0 0 2 2 2 2 CbiX Ferrochelatase PF00762.19 CDL00447.1 - 3.4e-08 32.9 0.0 0.0002 20.6 0.0 2.1 2 0 0 2 2 2 2 Ferrochelatase CbiK PF06180.11 CDL00447.1 - 2.2e-06 27.2 0.0 0.0021 17.4 0.0 2.4 2 1 1 3 3 3 3 Cobalt chelatase (CbiK) Zip PF02535.22 CDL00447.1 - 0.44 9.7 5.2 0.51 9.5 5.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.14 CDL00447.1 - 2.2 7.6 21.9 4.4 6.7 21.9 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CobD_Cbib PF03186.13 CDL00448.1 - 2e-103 345.4 3.1 2.3e-103 345.2 3.1 1.0 1 0 0 1 1 1 1 CobD/Cbib protein UAA PF08449.11 CDL00448.1 - 0.01 15.1 0.0 0.12 11.6 0.0 2.2 1 1 1 2 2 2 0 UAA transporter family FA_desaturase PF00487.24 CDL00448.1 - 0.014 15.2 0.9 0.014 15.2 0.9 2.5 1 1 1 2 2 2 0 Fatty acid desaturase AmpE PF17113.5 CDL00448.1 - 0.06 12.7 1.4 0.094 12.0 1.3 1.4 1 1 0 1 1 1 0 Regulatory signalling modulator protein AmpE GATase_3 PF07685.14 CDL00449.1 - 8e-57 192.0 0.0 1.1e-56 191.6 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AAA_26 PF13500.6 CDL00449.1 - 9.2e-19 68.0 0.0 2.8e-18 66.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 CDL00449.1 - 1.1e-16 61.1 0.0 2.2e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain GATase_5 PF13507.6 CDL00449.1 - 0.12 11.5 0.1 0.36 9.9 0.0 1.7 2 0 0 2 2 2 0 CobB/CobQ-like glutamine amidotransferase domain BPL_N PF09825.9 CDL00449.1 - 0.21 10.6 0.0 0.31 10.1 0.0 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Ysc84 PF04366.12 CDL00450.1 - 1.1e-26 93.0 1.3 1.2e-26 92.9 0.3 1.6 2 1 0 2 2 2 1 Las17-binding protein actin regulator CobA_CobO_BtuR PF02572.15 CDL00451.1 - 7.4e-61 205.4 0.0 9.5e-61 205.0 0.0 1.1 1 0 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Co_AT_N PF12557.8 CDL00451.1 - 0.0017 18.2 5.3 0.0037 17.1 5.3 1.5 1 0 0 1 1 1 1 Cob(I)alamin adenosyltransferase N terminal Tetraspanin PF00335.20 CDL00452.1 - 0.45 10.2 6.4 0.56 9.9 6.4 1.1 1 0 0 1 1 1 0 Tetraspanin family Gram_pos_anchor PF00746.21 CDL00452.1 - 4.9 7.2 6.5 1.8 8.5 1.3 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif tRNA-synt_1c PF00749.21 CDL00453.1 - 8.4e-47 159.6 0.0 1e-46 159.3 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Abhydrolase_2 PF02230.16 CDL00454.1 - 7.3e-36 124.0 0.0 8.1e-36 123.9 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 CDL00454.1 - 1.9e-05 24.2 0.0 0.00077 19.0 0.0 2.1 1 1 1 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 CDL00454.1 - 6.6e-05 22.6 0.0 9.5e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 CDL00454.1 - 0.00059 19.2 1.7 0.32 10.2 0.1 2.7 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDL00454.1 - 0.00092 18.9 0.6 0.014 15.0 0.0 2.3 2 1 1 3 3 3 1 alpha/beta hydrolase fold FSH1 PF03959.13 CDL00454.1 - 0.0011 18.7 0.4 0.0029 17.3 0.4 2.2 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 CDL00454.1 - 0.19 12.3 15.4 0.34 11.5 15.4 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Asp2 PF16929.5 CDL00454.1 - 0.23 10.4 0.0 0.28 10.1 0.0 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter HNH_5 PF14279.6 CDL00455.1 - 1e-20 73.3 0.0 1.4e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 HNH endonuclease HNH PF01844.23 CDL00455.1 - 1.9e-14 53.5 0.1 2.7e-14 53.1 0.1 1.2 1 0 0 1 1 1 1 HNH endonuclease HNH_4 PF13395.6 CDL00455.1 - 2.7e-05 24.0 0.0 4.2e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 HNH endonuclease MFS_1 PF07690.16 CDL00456.1 - 1.4e-15 57.1 84.9 1.3e-14 54.0 47.6 2.4 1 1 2 3 3 3 2 Major Facilitator Superfamily Acatn PF13000.7 CDL00456.1 - 5.5e-09 35.1 1.0 5.5e-09 35.1 1.0 2.7 2 1 1 3 3 3 2 Acetyl-coenzyme A transporter 1 AlaDh_PNT_C PF01262.21 CDL00457.1 - 6.6e-82 273.9 1.0 8.5e-82 273.6 1.0 1.1 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CDL00457.1 - 4.7e-47 159.7 0.0 8.6e-47 158.9 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain 2-Hacid_dh_C PF02826.19 CDL00457.1 - 5.3e-06 25.9 0.0 1.1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 CDL00457.1 - 4.9e-05 23.8 0.1 0.00012 22.6 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CDL00457.1 - 0.00016 21.7 0.0 0.0003 20.9 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 CDL00457.1 - 0.00037 19.8 0.2 0.0009 18.6 0.3 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 CDL00457.1 - 0.011 16.0 0.1 0.027 14.7 0.1 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CDL00457.1 - 0.015 15.8 0.1 0.029 14.8 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding DAO PF01266.24 CDL00457.1 - 0.019 14.6 2.8 0.031 13.9 2.1 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CDL00457.1 - 0.024 14.5 0.3 0.058 13.3 0.1 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 CDL00457.1 - 0.091 11.8 0.5 0.12 11.4 0.5 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_8 PF13450.6 CDL00457.1 - 0.53 10.6 4.0 0.4 10.9 0.3 2.8 4 0 0 4 4 3 0 NAD(P)-binding Rossmann-like domain Pyrophosphatase PF00719.19 CDL00458.1 - 8.4e-55 184.9 0.0 9.7e-55 184.7 0.0 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase Collar PF07484.12 CDL00459.1 - 3.9e-19 68.4 1.0 1.3e-18 66.7 0.3 2.2 2 0 0 2 2 2 1 Phage Tail Collar Domain Collar PF07484.12 CDL00460.1 - 3.7e-16 58.9 0.5 1.1e-15 57.3 0.5 1.8 1 0 0 1 1 1 1 Phage Tail Collar Domain DAGK_cat PF00781.24 CDL00460.1 - 0.046 13.3 0.1 0.1 12.2 0.1 1.5 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Big_2 PF02368.18 CDL00460.1 - 0.052 13.4 4.7 0.13 12.2 4.7 1.7 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 2) DUF4781 PF16013.5 CDL00460.1 - 1.1 8.0 4.5 1.5 7.5 4.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) Collar PF07484.12 CDL00461.1 - 1.3e-13 50.8 0.9 3e-13 49.5 0.9 1.7 1 0 0 1 1 1 1 Phage Tail Collar Domain Big_6 PF17936.1 CDL00463.1 - 9.7e-55 182.8 122.8 1.2e-11 44.7 8.6 11.3 9 6 0 9 9 9 8 Bacterial Ig domain DUF4347 PF14252.6 CDL00463.1 - 6.2e-47 159.5 3.7 6.2e-47 159.5 3.7 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4347) Big_3_3 PF13750.6 CDL00463.1 - 1.4e-19 70.3 27.8 4.7e-05 23.1 2.4 7.8 7 2 0 7 7 7 6 Bacterial Ig-like domain (group 3) Big_3_5 PF16640.5 CDL00463.1 - 5e-09 36.2 212.8 0.0021 18.2 15.0 11.5 9 1 3 12 12 12 7 Bacterial Ig-like domain (group 3) Y_Y_Y PF07495.13 CDL00463.1 - 1.9e-06 27.8 0.0 16 5.5 0.0 6.5 7 0 0 7 7 7 1 Y_Y_Y domain DUF4625 PF15418.6 CDL00463.1 - 0.00028 21.1 3.8 68 3.7 0.0 7.2 5 2 2 7 7 7 0 Domain of unknown function (DUF4625) Big_3_4 PF13754.6 CDL00463.1 - 0.00039 20.1 6.8 2.6 7.8 0.0 5.4 6 0 0 6 6 6 2 Domain of unknown function Big_7 PF17957.1 CDL00463.1 - 0.001 19.8 130.9 0.0098 16.6 6.5 10.6 9 1 0 9 9 9 4 Bacterial Ig domain HYR PF02494.16 CDL00463.1 - 1 9.7 33.7 2.5 8.5 0.3 8.5 6 4 0 7 7 7 0 HYR domain Big_6 PF17936.1 CDL00464.1 - 2.9e-26 91.6 47.7 8.8e-11 41.9 11.6 5.8 4 3 0 4 4 4 3 Bacterial Ig domain Big_3_5 PF16640.5 CDL00464.1 - 4.5e-10 39.6 67.6 0.0013 18.8 12.3 4.0 4 0 0 4 4 4 3 Bacterial Ig-like domain (group 3) He_PIG PF05345.12 CDL00464.1 - 7.3e-06 26.1 0.1 7.3e-06 26.1 0.1 6.8 5 2 0 5 5 4 1 Putative Ig domain bMG3 PF11974.8 CDL00464.1 - 0.00012 22.1 15.5 0.0074 16.3 1.2 4.4 3 1 0 3 3 3 2 Bacterial alpha-2-macroglobulin MG3 domain HYR PF02494.16 CDL00464.1 - 0.00036 20.8 3.8 0.43 10.9 0.0 4.0 4 0 0 4 4 4 2 HYR domain Cadherin_5 PF17892.1 CDL00464.1 - 0.0056 16.6 20.9 1.3 9.0 2.2 4.5 4 0 0 4 4 4 3 Cadherin-like domain Big_3_3 PF13750.6 CDL00464.1 - 0.0088 15.7 3.5 3.4 7.3 0.9 3.4 2 1 1 3 3 3 1 Bacterial Ig-like domain (group 3) Y_Y_Y PF07495.13 CDL00464.1 - 0.013 15.5 0.0 0.042 13.8 0.0 1.9 1 0 0 1 1 1 0 Y_Y_Y domain TcfC PF16967.5 CDL00464.1 - 0.035 13.6 0.0 23 4.6 0.0 3.4 3 0 0 3 3 3 0 E-set like domain Big_3_4 PF13754.6 CDL00464.1 - 0.078 12.7 0.1 12 5.7 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function DUF4625 PF15418.6 CDL00464.1 - 0.088 13.1 0.1 4.3 7.6 0.0 3.2 2 1 2 4 4 4 0 Domain of unknown function (DUF4625) CBM60 PF16841.5 CDL00464.1 - 1.7 9.1 11.6 12 6.5 0.4 4.0 2 1 0 3 3 3 0 Ca-dependent carbohydrate-binding module xylan-binding Big_9 PF17963.1 CDL00464.1 - 2.2 9.1 63.1 1.4 9.8 5.0 5.8 2 2 2 4 4 4 0 Bacterial Ig domain OEP PF02321.18 CDL00465.1 - 1.1e-23 84.1 27.5 1.1e-16 61.2 9.6 2.2 2 0 0 2 2 2 2 Outer membrane efflux protein HAUS2 PF15003.6 CDL00465.1 - 0.018 14.8 0.6 0.047 13.4 0.6 1.7 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 2 TPR_7 PF13176.6 CDL00465.1 - 1.1 9.5 5.3 0.83 9.8 0.2 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat HlyD_3 PF13437.6 CDL00466.1 - 9.5e-16 58.4 0.3 2.3e-14 54.0 0.1 2.4 2 1 0 2 2 2 1 HlyD family secretion protein HlyD_D23 PF16576.5 CDL00466.1 - 7.7e-14 51.4 0.2 1.5e-13 50.5 0.2 1.4 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDL00466.1 - 1.1e-08 34.7 0.0 0.004 16.9 0.1 2.6 2 0 0 2 2 2 2 Biotin-lipoyl like RNA_pol_I_A49 PF06870.12 CDL00466.1 - 0.022 13.6 0.2 1.8 7.3 0.0 2.1 1 1 1 2 2 2 0 A49-like RNA polymerase I associated factor Biotin_lipoyl PF00364.22 CDL00466.1 - 0.054 13.3 0.0 2.3 8.1 0.0 2.7 3 0 0 3 3 3 0 Biotin-requiring enzyme HlyD_3 PF13437.6 CDL00467.1 - 7.9e-14 52.3 1.6 1.8e-09 38.2 0.2 2.3 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CDL00467.1 - 5.6e-09 35.5 0.5 8.2e-09 35.0 0.5 1.1 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDL00467.1 - 9.6e-08 31.7 0.0 2.8e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like Phage_CI_repr PF07022.13 CDL00467.1 - 0.033 14.3 0.1 0.091 12.9 0.0 1.7 2 0 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain DUF2985 PF11204.8 CDL00467.1 - 0.078 13.1 0.0 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2985) HlyD_3 PF13437.6 CDL00468.1 - 7.1e-10 39.5 0.0 4.6e-07 30.5 0.0 2.4 2 0 0 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 CDL00468.1 - 4.4e-07 29.6 0.1 1.1e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 Biotin-lipoyl like HlyD_D23 PF16576.5 CDL00468.1 - 6.3e-05 22.3 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Peptidase_M50 PF02163.22 CDL00468.1 - 0.00014 21.2 2.4 0.0014 17.9 0.5 3.0 2 1 1 3 3 3 1 Peptidase family M50 Biotin_lipoyl PF00364.22 CDL00468.1 - 0.12 12.2 0.0 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 Biotin-requiring enzyme GDYXXLXY PF14345.6 CDL00468.1 - 0.13 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 GDYXXLXY protein Peptidase_M23 PF01551.22 CDL00468.1 - 0.21 11.8 0.0 0.95 9.7 0.0 1.9 2 0 0 2 2 2 0 Peptidase family M23 MM_CoA_mutase PF01642.22 CDL00470.1 - 2e-245 815.2 2.0 2.3e-245 815.0 2.0 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 CDL00470.1 - 6.8e-14 51.9 0.7 1.8e-13 50.6 0.7 1.8 1 0 0 1 1 1 1 B12 binding domain PhnI PF05861.12 CDL00470.1 - 0.049 12.5 0.6 0.22 10.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial phosphonate metabolism protein (PhnI) DUF4743 PF15916.5 CDL00471.1 - 6.8e-35 119.7 0.1 1.7e-34 118.4 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4743) HpcH_HpaI PF03328.14 CDL00472.1 - 1.3e-25 89.8 0.0 2.4e-25 89.0 0.0 1.5 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 CDL00472.1 - 0.0049 16.1 0.0 0.99 8.5 0.0 2.2 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold DUF1150 PF06620.11 CDL00474.1 - 5.5e-14 52.0 0.0 2.1e-11 43.7 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1150) Stonin2_N PF12016.8 CDL00474.1 - 0.0011 18.5 0.0 0.0012 18.3 0.0 1.0 1 0 0 1 1 1 1 Stonin 2 HSP20 PF00011.21 CDL00475.1 - 6.3e-16 58.4 0.0 9.4e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDL00475.1 - 0.054 13.1 0.0 0.12 11.9 0.0 1.6 1 1 0 1 1 1 0 HSP20-like domain found in ArsA MacB_PCD PF12704.7 CDL00476.1 - 9.7e-08 32.6 1.9 4e-06 27.3 0.1 3.3 3 0 0 3 3 3 2 MacB-like periplasmic core domain FtsX PF02687.21 CDL00476.1 - 6.6e-07 29.7 21.5 0.00011 22.6 7.5 6.0 4 2 1 5 5 5 2 FtsX-like permease family ABC_tran PF00005.27 CDL00477.1 - 1.2e-32 113.3 0.0 1.5e-32 112.9 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDL00477.1 - 1.9e-07 31.2 0.3 0.0083 16.0 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDL00477.1 - 0.0015 18.0 0.0 0.16 11.4 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDL00477.1 - 0.0048 16.8 0.2 0.0074 16.2 0.2 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CDL00477.1 - 0.0064 16.2 0.3 0.012 15.3 0.3 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDL00477.1 - 0.012 16.1 0.4 0.018 15.4 0.4 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 CDL00477.1 - 0.043 13.5 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDL00477.1 - 0.078 12.7 0.1 0.2 11.4 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 CDL00477.1 - 0.1 13.1 0.1 0.15 12.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CDL00477.1 - 0.17 12.0 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Lipase_GDSL_2 PF13472.6 CDL00478.1 - 1.1e-23 84.6 1.3 1.3e-23 84.3 1.3 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CDL00478.1 - 5.7e-10 39.5 0.0 7.8e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase OSK PF17182.4 CDL00478.1 - 0.14 11.4 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 OSK domain FIST_C PF10442.9 CDL00479.1 - 1.1e-24 86.9 0.1 3.6e-24 85.2 0.1 1.8 2 0 0 2 2 2 1 FIST C domain FIST PF08495.10 CDL00479.1 - 2.5e-21 76.4 2.9 1.5e-17 64.2 0.4 3.0 2 1 1 3 3 3 2 FIST N domain LigT_PEase PF02834.16 CDL00480.1 - 6.3e-28 96.8 0.3 8.4e-15 54.7 0.0 2.0 2 0 0 2 2 2 2 LigT like Phosphoesterase 2_5_RNA_ligase2 PF13563.6 CDL00480.1 - 5.9e-17 62.0 0.1 6.8e-17 61.8 0.1 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily AKAP7_NLS PF10469.9 CDL00480.1 - 0.00085 19.3 0.0 0.0013 18.6 0.0 1.3 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain HVSL PF09749.9 CDL00480.1 - 0.049 13.1 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein DUF5061 PF16587.5 CDL00481.1 - 0.017 15.2 0.1 3.5 7.7 0.0 2.2 2 0 0 2 2 2 0 17 kDa common-antigen outer membrane protein LPAM_2 PF13627.6 CDL00481.1 - 0.082 12.8 1.5 0.17 11.8 1.5 1.5 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site MFS_1 PF07690.16 CDL00482.1 - 3e-27 95.5 56.6 3.7e-17 62.3 35.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cytochrom_C PF00034.21 CDL00483.1 - 5.6e-05 24.2 0.1 0.0031 18.6 0.1 2.1 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CDL00483.1 - 6.3e-05 23.2 0.0 9.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Hemerythrin PF01814.23 CDL00484.1 - 1.5e-12 48.2 0.4 1.5e-12 48.2 0.4 1.4 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain YdjM PF04307.14 CDL00485.1 - 2.5e-34 118.1 11.3 3e-34 117.8 11.3 1.1 1 0 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase Zn_dep_PLPC PF00882.18 CDL00485.1 - 0.008 16.2 0.2 0.033 14.2 0.2 1.8 1 1 0 1 1 1 1 Zinc dependent phospholipase C DUF2583 PF10762.9 CDL00485.1 - 0.61 10.5 4.8 0.62 10.5 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2583) Nitroreductase PF00881.24 CDL00486.1 - 6.9e-10 39.2 0.0 2.4e-09 37.5 0.0 1.7 1 1 0 1 1 1 1 Nitroreductase family Polysacc_deac_1 PF01522.21 CDL00487.1 - 2.6e-27 95.2 0.0 3.7e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 CDL00487.1 - 4.1e-06 26.2 0.0 5.8e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 CMS1 PF14617.6 CDL00487.1 - 0.31 10.3 0.0 0.45 9.8 0.0 1.1 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DnaJ PF00226.31 CDL00488.1 - 2.5e-17 62.7 0.1 3.9e-17 62.1 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain SH3_3 PF08239.11 CDL00488.1 - 3e-07 30.6 0.0 6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.13 CDL00488.1 - 0.0089 15.8 0.2 0.058 13.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial SH3 domain GW PF13457.6 CDL00488.1 - 0.042 14.5 0.0 1 10.0 0.0 2.3 2 0 0 2 2 2 0 GW (Gly-Tryp) dipeptide domain HXXSHH PF07586.11 CDL00488.1 - 0.15 11.7 0.1 0.34 10.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1552) Cytochrome_C7 PF14522.6 CDL00489.1 - 0.019 14.9 0.0 7.2 6.7 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CDL00489.1 - 0.031 14.0 1.4 5.2 6.9 0.1 2.3 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) PDZ_1 PF12812.7 CDL00489.1 - 0.058 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 PDZ-like domain Cytochrome_CBB3 PF13442.6 CDL00489.1 - 0.7 10.3 11.6 0.21 11.9 2.3 2.4 1 1 1 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III Fer2_BFD PF04324.15 CDL00489.1 - 2.1 8.8 5.3 6.7 7.2 0.1 2.7 3 0 0 3 3 3 0 BFD-like [2Fe-2S] binding domain Cytochrom_C PF00034.21 CDL00489.1 - 7 7.9 6.4 4.8e+02 2.0 6.4 2.3 1 1 0 1 1 1 0 Cytochrome c Cytochrome_CBB3 PF13442.6 CDL00490.1 - 0.00016 21.9 0.1 0.00063 20.0 0.1 1.8 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 CDL00490.1 - 0.0003 20.5 0.0 0.00043 20.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c-550 domain Cytochrom_C PF00034.21 CDL00490.1 - 0.003 18.7 0.0 0.0069 17.5 0.0 1.6 1 1 0 1 1 1 1 Cytochrome c Haem_bd PF14376.6 CDL00490.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.5 1 1 0 1 1 1 0 Haem-binding domain CMD PF02627.20 CDL00491.1 - 1.8e-21 76.0 0.3 2.4e-21 75.6 0.3 1.2 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family HTH_39 PF14090.6 CDL00491.1 - 0.087 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain MafB19-deam PF14437.6 CDL00492.1 - 1.2e-29 102.8 0.0 1.3e-29 102.7 0.0 1.0 1 0 0 1 1 1 1 MafB19-like deaminase dCMP_cyt_deam_1 PF00383.23 CDL00492.1 - 3e-25 88.0 0.2 3.8e-25 87.7 0.2 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Bd3614-deam PF14439.6 CDL00492.1 - 0.00027 21.0 3.2 0.003 17.6 3.2 2.3 1 1 0 1 1 1 1 Bd3614-like deaminase SNAD4 PF18750.1 CDL00492.1 - 0.00054 20.1 0.0 0.00082 19.5 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 CDL00492.1 - 0.0017 18.4 0.0 0.0026 17.9 0.0 1.2 1 0 0 1 1 1 1 APOBEC3 APOBEC2 PF18772.1 CDL00492.1 - 0.0024 18.0 0.0 0.0032 17.5 0.0 1.2 1 0 0 1 1 1 1 APOBEC2 Orbi_VP7 PF00897.17 CDL00492.1 - 0.0026 16.8 0.6 0.0034 16.4 0.6 1.1 1 0 0 1 1 1 1 Orbivirus inner capsid protein VP7 APOBEC_N PF08210.11 CDL00492.1 - 0.0038 17.1 0.0 0.0048 16.8 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain NAD2 PF18782.1 CDL00492.1 - 0.024 14.7 0.0 0.032 14.3 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 NAD1 PF18778.1 CDL00492.1 - 0.031 14.4 0.0 0.042 13.9 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 Toxin-deaminase PF14424.6 CDL00492.1 - 0.071 13.2 0.0 0.096 12.8 0.0 1.1 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases Peptidase_C26 PF07722.13 CDL00493.1 - 2.3e-61 207.3 0.0 2.6e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Peptidase C26 GATase PF00117.28 CDL00493.1 - 4.7e-17 62.4 0.1 7.1e-17 61.8 0.1 1.4 1 1 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 CDL00493.1 - 0.0046 16.6 0.4 0.012 15.2 0.3 1.7 1 1 1 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase_5 PF13507.6 CDL00493.1 - 0.0094 15.1 0.0 0.013 14.6 0.0 1.1 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain PseudoU_synth_2 PF00849.22 CDL00494.1 - 1.6e-13 51.1 0.0 3.2e-12 46.8 0.0 2.1 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CDL00494.1 - 9e-13 47.7 0.1 2.4e-12 46.3 0.1 1.8 1 0 0 1 1 1 1 S4 domain Cons_hypoth95 PF03602.15 CDL00495.1 - 1.6e-44 151.7 0.0 1.8e-44 151.6 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 CDL00495.1 - 2.5e-05 23.9 0.0 3.2e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDL00495.1 - 7.7e-05 23.3 0.0 0.00012 22.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RsmJ PF04378.13 CDL00495.1 - 0.0089 15.3 0.0 0.011 15.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA large subunit methyltransferase D, RlmJ Met_10 PF02475.16 CDL00495.1 - 0.018 14.8 0.0 0.024 14.4 0.0 1.1 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_31 PF13847.6 CDL00495.1 - 0.069 12.9 0.0 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain N6_N4_Mtase PF01555.18 CDL00495.1 - 0.27 10.9 0.0 0.37 10.5 0.0 1.2 1 0 0 1 1 1 0 DNA methylase Bax1-I PF01027.20 CDL00496.1 - 3.9e-64 216.3 33.0 4.4e-64 216.1 33.0 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Peripla_BP_6 PF13458.6 CDL00497.1 - 5.7e-37 128.2 8.7 7.2e-37 127.8 8.7 1.1 1 0 0 1 1 1 1 Periplasmic binding protein LppC PF04348.13 CDL00497.1 - 2.3e-16 59.7 0.1 3.1e-16 59.3 0.1 1.1 1 0 0 1 1 1 1 LppC putative lipoprotein ANF_receptor PF01094.28 CDL00497.1 - 9.3e-11 41.4 0.0 1.4e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_4 PF13407.6 CDL00497.1 - 3.2e-05 23.7 0.0 5.7e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 Periplasmic binding protein domain TP_methylase PF00590.20 CDL00498.1 - 2.6e-28 99.4 2.7 2.6e-28 99.4 2.7 1.4 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases UPF0102 PF02021.17 CDL00499.1 - 1.5e-21 76.4 0.0 1.7e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0102 DUF1853 PF08907.11 CDL00499.1 - 0.0024 17.6 0.0 0.0044 16.8 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1853) NERD PF08378.11 CDL00499.1 - 0.0047 17.4 0.0 0.0055 17.2 0.0 1.2 1 0 0 1 1 1 1 Nuclease-related domain Hjc PF01870.18 CDL00499.1 - 0.031 14.2 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 Archaeal holliday junction resolvase (hjc) DUF234 PF03008.14 CDL00499.1 - 0.069 13.6 0.0 0.092 13.2 0.0 1.2 1 0 0 1 1 1 0 Archaea bacterial proteins of unknown function AHJR-like PF18743.1 CDL00499.1 - 0.25 10.9 0.0 0.33 10.5 0.0 1.4 1 1 0 1 1 1 0 REase_AHJR-like BON PF04972.17 CDL00500.1 - 1.1e-25 89.7 3.9 1.4e-13 50.9 0.4 2.4 2 1 0 2 2 2 2 BON domain Transglut_core2 PF13369.6 CDL00501.1 - 1.5e-22 79.8 0.1 2.2e-22 79.3 0.1 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily TPR_9 PF13371.6 CDL00501.1 - 1.1e-13 51.1 3.5 1.1e-13 51.1 3.5 2.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDL00501.1 - 0.024 15.3 2.2 0.024 15.3 2.2 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat GSH-S_ATP PF02955.16 CDL00502.1 - 2e-73 245.5 0.0 2.7e-73 245.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain GSH-S_N PF02951.14 CDL00502.1 - 1.2e-42 144.8 0.6 1.8e-42 144.2 0.6 1.3 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, N-terminal domain RimK PF08443.11 CDL00502.1 - 1.7e-17 63.6 0.0 2.4e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATPgrasp_YheCD PF14398.6 CDL00502.1 - 1.2e-05 24.7 0.1 0.00021 20.6 0.1 2.3 1 1 0 1 1 1 1 YheC/D like ATP-grasp GSP_synth PF03738.14 CDL00502.1 - 0.0012 18.0 0.0 0.0069 15.6 0.0 2.0 2 0 0 2 2 2 1 Glutathionylspermidine synthase preATP-grasp ATP-grasp_3 PF02655.14 CDL00502.1 - 0.0027 17.8 0.0 0.0048 17.0 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 CDL00502.1 - 0.092 12.0 0.0 0.36 10.0 0.0 2.0 1 1 0 1 1 1 0 Sugar-transfer associated ATP-grasp DUF3365 PF11845.8 CDL00503.1 - 9.8e-28 97.4 0.0 1.4e-26 93.7 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3365) HATPase_c PF02518.26 CDL00503.1 - 2.2e-23 82.9 0.0 4.6e-23 81.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDL00503.1 - 6.1e-10 39.0 0.0 2.4e-09 37.1 0.0 2.0 1 1 1 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CDL00503.1 - 0.0096 15.8 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 CDL00503.1 - 0.093 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mg_chelatase PF01078.21 CDL00504.1 - 4.2e-95 317.0 0.0 6.7e-95 316.3 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ChlI PF13541.6 CDL00504.1 - 4.4e-41 139.5 0.0 6.9e-41 138.9 0.0 1.3 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase Mg_chelatase_C PF13335.6 CDL00504.1 - 1.1e-28 99.6 2.1 2.7e-28 98.4 2.1 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI C-terminal AAA_5 PF07728.14 CDL00504.1 - 8.2e-09 35.6 0.0 2.1e-08 34.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) MCM PF00493.23 CDL00504.1 - 8.4e-09 34.9 0.0 5.2e-07 29.0 0.0 2.2 2 0 0 2 2 2 1 MCM P-loop domain Sigma54_activat PF00158.26 CDL00504.1 - 1.8e-06 27.7 0.0 0.0023 17.6 0.0 2.2 2 0 0 2 2 2 2 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CDL00504.1 - 0.0007 19.7 0.0 0.46 10.6 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_32 PF13654.6 CDL00504.1 - 0.00071 18.5 0.0 0.12 11.1 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CDL00504.1 - 0.0064 16.9 1.0 0.031 14.7 0.0 2.4 3 0 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 CDL00504.1 - 0.011 15.5 0.0 2.3 7.9 0.0 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CDL00504.1 - 0.012 15.8 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDL00504.1 - 0.017 15.4 0.0 0.076 13.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 CDL00504.1 - 0.018 15.4 0.0 0.2 12.1 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CDL00504.1 - 0.13 12.0 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CDL00504.1 - 0.14 12.7 0.0 0.34 11.4 0.0 1.6 1 0 0 1 1 1 0 ABC transporter IstB_IS21 PF01695.17 CDL00504.1 - 0.14 11.9 0.3 0.34 10.6 0.1 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_7 PF12775.7 CDL00504.1 - 0.16 11.5 0.0 0.81 9.2 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region DDE_3 PF13358.6 CDL00507.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL00507.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDL00508.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL00508.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL00508.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL00508.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL00508.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL00508.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain Exo_endo_phos PF03372.23 CDL00509.1 - 2.9e-22 79.3 0.7 3.4e-22 79.1 0.7 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LolA PF03548.15 CDL00510.1 - 3.7e-26 91.8 0.0 4.4e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Outer membrane lipoprotein carrier protein LolA DUF2236 PF09995.9 CDL00510.1 - 0.12 12.5 0.0 0.16 12.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2236) DUF5419 PF17441.2 CDL00510.1 - 0.19 11.8 0.0 0.37 10.9 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5419) FtsK_SpoIIIE PF01580.18 CDL00511.1 - 1.2e-65 221.3 1.0 2e-65 220.5 1.0 1.4 1 1 0 1 1 1 1 FtsK/SpoIIIE family FtsK_alpha PF17854.1 CDL00511.1 - 8.9e-30 102.8 0.0 1.6e-29 102.0 0.0 1.4 1 0 0 1 1 1 1 FtsK alpha domain FtsK_gamma PF09397.10 CDL00511.1 - 5.1e-27 93.5 0.1 1.2e-26 92.3 0.1 1.7 1 0 0 1 1 1 1 Ftsk gamma domain FtsK_4TM PF13491.6 CDL00511.1 - 3e-19 69.3 13.2 5.2e-19 68.6 13.2 1.4 1 0 0 1 1 1 1 4TM region of DNA translocase FtsK/SpoIIIE AAA_10 PF12846.7 CDL00511.1 - 4.2e-06 25.9 0.0 0.0032 16.4 0.0 2.2 2 0 0 2 2 2 2 AAA-like domain DUF87 PF01935.17 CDL00511.1 - 8.4e-06 26.0 0.0 1.5e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Helicase HerA, central domain TniB PF05621.11 CDL00511.1 - 0.0022 17.5 0.5 1 8.7 0.0 2.9 3 0 0 3 3 3 2 Bacterial TniB protein AAA_22 PF13401.6 CDL00511.1 - 0.0054 17.0 0.2 0.046 14.0 0.2 2.3 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 CDL00511.1 - 0.0055 15.8 0.0 0.013 14.6 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 CDL00511.1 - 0.015 14.2 0.0 0.037 13.0 0.0 1.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DEAD PF00270.29 CDL00511.1 - 0.071 12.9 0.2 0.32 10.7 0.2 1.9 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_29 PF13555.6 CDL00511.1 - 0.088 12.6 0.1 0.32 10.8 0.1 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain Aminotran_1_2 PF00155.21 CDL00512.1 - 9.3e-36 123.7 0.0 1.1e-35 123.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Ammonium_transp PF00909.21 CDL00513.1 - 9.1e-122 406.6 40.8 1.2e-121 406.2 40.8 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family P-II PF00543.22 CDL00514.1 - 1.8e-43 147.3 1.8 2e-43 147.1 1.8 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF3240 PF11582.8 CDL00514.1 - 0.0072 16.4 0.0 0.0091 16.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3240) SHS2_FTSA PF02491.20 CDL00514.1 - 0.01 16.2 0.2 3.9 7.9 0.2 2.2 2 0 0 2 2 2 0 SHS2 domain inserted in FTSA CdAMP_rec PF06153.11 CDL00514.1 - 0.039 14.1 0.9 2.7 8.3 0.9 2.8 1 1 0 1 1 1 0 Cyclic-di-AMP receptor Cdc6_C PF09079.11 CDL00514.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain FAD_binding_3 PF01494.19 CDL00515.1 - 6.2e-33 114.5 0.1 8.2e-33 114.1 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CDL00515.1 - 5.4e-08 32.3 2.0 0.0028 16.8 0.0 3.1 3 0 0 3 3 3 2 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CDL00515.1 - 5.4e-07 29.1 0.7 0.0059 15.9 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDL00515.1 - 1.6e-06 27.9 4.6 3.3e-05 23.7 1.3 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase SE PF08491.10 CDL00515.1 - 4.8e-05 22.5 0.2 7e-05 22.0 0.2 1.2 1 0 0 1 1 1 1 Squalene epoxidase NAD_binding_8 PF13450.6 CDL00515.1 - 0.00039 20.6 0.7 0.0011 19.1 0.7 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CDL00515.1 - 0.0008 19.9 0.1 0.27 11.8 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CDL00515.1 - 0.0018 17.7 0.8 0.018 14.3 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 CDL00515.1 - 0.002 17.1 0.5 0.016 14.1 0.3 2.3 3 0 0 3 3 3 1 Tryptophan halogenase FAD_oxidored PF12831.7 CDL00515.1 - 0.0075 15.7 5.2 0.087 12.1 4.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDL00515.1 - 0.011 14.9 5.6 0.02 14.0 2.1 2.2 2 0 0 2 2 2 0 FAD binding domain ApbA PF02558.16 CDL00515.1 - 0.025 14.3 0.3 0.041 13.5 0.3 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_9 PF13454.6 CDL00515.1 - 0.032 14.2 2.2 1.2 9.2 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 CDL00515.1 - 0.037 12.7 2.4 0.062 12.0 1.6 1.6 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 CDL00515.1 - 0.058 12.6 0.3 0.13 11.4 0.1 1.6 2 0 0 2 2 2 0 Thi4 family Pyr_redox_3 PF13738.6 CDL00515.1 - 0.25 10.6 0.3 0.75 9.0 0.7 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDL00515.1 - 0.67 9.0 3.3 0.32 10.0 1.3 1.3 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF1178 PF06676.11 CDL00516.1 - 9.2e-22 78.0 0.0 1.1e-21 77.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1178) Zn-ribbon_8 PF09723.10 CDL00516.1 - 0.00083 19.4 0.1 0.00083 19.4 0.1 2.3 2 2 0 2 2 2 1 Zinc ribbon domain Phage_integrase PF00589.22 CDL00517.1 - 1.6e-42 145.2 0.0 2e-42 144.9 0.0 1.1 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_1 PF02899.17 CDL00517.1 - 2.5e-15 56.5 0.1 1.7e-14 53.9 0.0 2.2 2 1 1 3 3 3 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 CDL00517.1 - 6.1e-06 26.6 0.0 1.5e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain GTF2I PF02946.14 CDL00517.1 - 0.076 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 GTF2I-like repeat DUF21 PF01595.20 CDL00522.1 - 9e-41 139.5 4.0 1.3e-40 138.9 4.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CorC_HlyC PF03471.17 CDL00522.1 - 3.6e-20 71.7 0.1 1.7e-19 69.6 0.0 2.2 2 0 0 2 2 2 1 Transporter associated domain CBS PF00571.28 CDL00522.1 - 6.6e-16 58.5 1.8 5.2e-07 30.0 0.0 3.7 4 0 0 4 4 4 2 CBS domain RNase_T PF00929.24 CDL00523.1 - 2.6e-34 119.2 0.0 3.4e-34 118.8 0.0 1.2 1 0 0 1 1 1 1 Exonuclease RNase_H_2 PF13482.6 CDL00523.1 - 1.3e-05 25.3 0.0 3.4e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_A_exo1 PF01612.20 CDL00523.1 - 0.01 15.6 0.0 0.041 13.6 0.0 1.9 1 1 0 1 1 1 0 3'-5' exonuclease Amidohydro_3 PF07969.11 CDL00523.1 - 0.013 15.0 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 Amidohydrolase family CoaE PF01121.20 CDL00524.1 - 1.7e-38 132.1 0.0 2e-38 131.8 0.0 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 CDL00524.1 - 0.076 13.6 0.6 0.71 10.4 0.1 2.5 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDL00524.1 - 0.1 12.8 0.1 0.36 11.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain Shikimate_dh_N PF08501.11 CDL00525.1 - 1.2e-25 89.6 0.0 2e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 CDL00525.1 - 2e-08 33.9 0.7 4e-08 32.9 0.7 1.5 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 CDL00525.1 - 8.9e-08 32.3 0.0 1.5e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CDL00525.1 - 0.00062 20.3 0.2 0.0018 18.8 0.1 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 CDL00525.1 - 0.0064 16.8 0.1 0.011 16.0 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Maf PF02545.14 CDL00526.1 - 7.2e-34 117.0 0.0 8e-34 116.9 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein T3SS_ATPase_C PF18269.1 CDL00526.1 - 0.069 13.0 0.1 0.32 10.9 0.0 2.0 2 0 0 2 2 2 0 T3SS EscN ATPase C-terminal domain Kinase-PPPase PF03618.14 CDL00527.1 - 2.7e-91 305.9 0.0 3.1e-91 305.7 0.0 1.0 1 0 0 1 1 1 1 Kinase/pyrophosphorylase URO-D PF01208.17 CDL00528.1 - 1.2e-118 396.3 0.0 1.3e-118 396.1 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Ferrochelatase PF00762.19 CDL00529.1 - 4.4e-108 361.1 0.0 5.4e-108 360.8 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 CDL00529.1 - 0.01 16.2 0.0 2 8.8 0.0 2.8 3 0 0 3 3 3 2 CbiX UPF0093 PF03653.13 CDL00530.1 - 3.4e-59 199.3 4.4 4e-59 199.1 4.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0093) CopD PF05425.13 CDL00530.1 - 0.0026 18.1 1.5 0.0026 18.1 1.5 1.8 1 1 1 2 2 2 1 Copper resistance protein D SirB PF04247.12 CDL00530.1 - 0.0027 17.8 10.5 0.11 12.6 10.7 2.4 1 1 0 1 1 1 1 Invasion gene expression up-regulator, SirB FA_desaturase PF00487.24 CDL00530.1 - 0.033 14.0 3.9 0.047 13.5 3.9 1.3 1 0 0 1 1 1 0 Fatty acid desaturase COX6C PF02937.15 CDL00530.1 - 1 9.5 3.2 1.3 9.2 0.1 2.4 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VIc Rho_RNA_bind PF07497.12 CDL00531.1 - 5.1e-33 112.8 0.0 9.1e-33 112.0 0.0 1.4 1 0 0 1 1 1 1 Rho termination factor, RNA-binding domain ATP-synt_ab PF00006.25 CDL00531.1 - 3.3e-23 82.5 0.1 4.5e-23 82.0 0.1 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Rho_N PF07498.12 CDL00531.1 - 1.6e-17 63.2 2.2 4.5e-17 61.7 2.2 1.9 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain OB_RNB PF08206.11 CDL00531.1 - 0.00024 20.7 0.0 0.00057 19.5 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease B OB domain AAA_25 PF13481.6 CDL00531.1 - 0.00042 19.9 0.2 0.0012 18.5 0.2 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDL00531.1 - 0.0016 18.7 0.1 0.0098 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CDL00531.1 - 0.013 15.5 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 CDL00531.1 - 0.042 14.3 0.0 0.11 12.9 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Terminase_GpA PF05876.12 CDL00531.1 - 0.049 12.2 0.1 3.3 6.2 0.0 2.1 2 0 0 2 2 2 0 Phage terminase large subunit (GpA) AAA_16 PF13191.6 CDL00531.1 - 0.15 12.4 0.0 0.44 10.9 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain DNA_binding_1 PF01035.20 CDL00533.1 - 4.7e-30 103.5 0.0 6e-30 103.2 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N PF02870.15 CDL00533.1 - 0.00025 21.8 0.0 0.0036 18.1 0.0 2.1 1 1 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Thioredox_DsbH PF03190.15 CDL00534.1 - 8.7e-74 246.9 0.0 1.5e-73 246.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 CDL00534.1 - 3.2e-09 36.8 0.0 7.2e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like GlcNAc_2-epim PF07221.11 CDL00534.1 - 8.6e-05 21.9 6.6 0.008 15.5 3.4 2.6 1 1 1 2 2 2 2 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Glyco_hydro_76 PF03663.14 CDL00534.1 - 0.00094 18.8 8.1 0.001 18.7 5.3 2.3 2 1 0 2 2 2 1 Glycosyl hydrolase family 76 Glyco_hydro_127 PF07944.12 CDL00534.1 - 0.11 11.0 0.4 0.26 9.7 0.4 1.6 1 1 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 DUF4568 PF15132.6 CDL00535.1 - 0.083 12.2 0.0 0.094 12.1 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4568) 2Fe-2S_thioredx PF01257.19 CDL00536.1 - 0.0019 18.1 0.0 0.0027 17.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Suc_Fer-like PF06999.12 CDL00536.1 - 0.037 13.9 0.2 0.076 12.9 0.2 1.5 1 1 0 1 1 1 0 Sucrase/ferredoxin-like MnmE_helical PF12631.7 CDL00537.1 - 1.1e-49 169.5 3.3 1.3e-49 169.1 3.3 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 CDL00537.1 - 6e-36 123.3 0.0 2.3e-34 118.2 0.0 3.0 2 1 1 3 3 3 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 CDL00537.1 - 1.4e-22 79.9 0.0 8e-22 77.5 0.0 2.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDL00537.1 - 4.2e-09 36.1 0.0 7.3e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CDL00537.1 - 4.4e-05 23.6 0.0 9.8e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 CDL00537.1 - 0.00016 21.9 0.6 0.00035 20.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AIG1 PF04548.16 CDL00537.1 - 0.00093 18.6 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 CDL00537.1 - 0.00099 19.1 0.0 0.014 15.3 0.0 2.6 1 1 1 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 CDL00537.1 - 0.0034 17.1 0.0 0.0059 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 CDL00537.1 - 0.013 15.1 0.3 0.19 11.3 0.1 2.3 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MCM PF00493.23 CDL00537.1 - 0.018 14.1 0.0 0.035 13.2 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain ABC_tran PF00005.27 CDL00537.1 - 0.11 13.1 0.0 0.22 12.0 0.0 1.6 1 0 0 1 1 1 0 ABC transporter DUF4148 PF13663.6 CDL00537.1 - 5.6 7.2 10.9 0.72 10.1 1.7 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4148) GIDA PF01134.22 CDL00538.1 - 4.4e-164 546.2 0.0 6e-164 545.8 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 CDL00538.1 - 1.2e-70 238.0 0.0 1.7e-70 237.5 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 CDL00538.1 - 3.7e-08 33.2 2.3 5.8e-08 32.5 2.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDL00538.1 - 6e-06 25.7 0.7 1.8e-05 24.1 0.7 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDL00538.1 - 6.7e-06 25.4 6.1 0.0068 15.5 3.4 2.4 2 0 0 2 2 2 2 FAD binding domain AlaDh_PNT_C PF01262.21 CDL00538.1 - 0.00074 18.9 0.8 0.0016 17.8 0.8 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 CDL00538.1 - 0.0064 16.1 4.1 0.92 9.0 0.1 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDL00538.1 - 0.016 15.2 0.2 0.016 15.2 0.2 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding Glyoxalase_3 PF13468.6 CDL00538.1 - 0.017 15.2 0.2 0.049 13.8 0.0 1.8 2 0 0 2 2 2 0 Glyoxalase-like domain Pyr_redox PF00070.27 CDL00538.1 - 0.039 14.5 0.4 0.097 13.2 0.4 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDL00538.1 - 0.12 11.4 2.1 3 6.8 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein YAcAr PF10686.9 CDL00538.1 - 0.16 12.0 1.1 2.7 8.0 0.0 2.6 2 0 0 2 2 2 0 YspA, cpYpsA-related SLOG family HI0933_like PF03486.14 CDL00538.1 - 0.47 9.1 4.8 1.3 7.7 1.7 2.8 3 0 0 3 3 3 0 HI0933-like protein Trp_halogenase PF04820.14 CDL00538.1 - 0.5 9.2 1.8 6.9 5.4 0.5 2.1 2 0 0 2 2 2 0 Tryptophan halogenase GidB PF02527.15 CDL00539.1 - 1.9e-43 147.9 0.0 2.3e-43 147.6 0.0 1.0 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G MTS PF05175.14 CDL00539.1 - 0.00058 19.5 0.0 0.0016 18.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDL00539.1 - 0.071 12.9 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 CDL00539.1 - 0.18 11.5 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase AAA_31 PF13614.6 CDL00540.1 - 2.2e-62 210.1 0.0 6.3e-62 208.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 CDL00540.1 - 3.3e-30 104.8 0.1 4.9e-30 104.2 0.1 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 CDL00540.1 - 2.5e-12 46.6 0.4 1.2e-10 41.2 0.4 2.1 1 1 0 1 1 1 1 ATPase MipZ ParA PF10609.9 CDL00540.1 - 1.9e-10 40.6 1.3 1.2e-08 34.8 0.2 2.5 2 1 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 CDL00540.1 - 2.5e-10 40.3 0.0 7.5e-10 38.7 0.0 1.8 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 CDL00540.1 - 3.4e-10 39.8 0.3 1.1e-05 25.0 0.1 2.1 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 CDL00540.1 - 6.6e-07 28.8 1.5 2.5e-06 26.9 0.3 2.1 2 1 0 2 2 2 1 Anion-transporting ATPase SRP54 PF00448.22 CDL00540.1 - 0.00029 20.5 0.6 0.077 12.6 0.6 2.3 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain VirC1 PF07015.11 CDL00540.1 - 0.0012 18.2 0.4 0.0023 17.3 0.2 1.5 2 0 0 2 2 2 1 VirC1 protein ATP_bind_1 PF03029.17 CDL00540.1 - 0.0027 17.5 0.0 0.16 11.8 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein FTHFS PF01268.19 CDL00540.1 - 0.044 12.0 0.6 0.07 11.3 0.6 1.2 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase CLP1_P PF16575.5 CDL00540.1 - 0.051 13.4 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_25 PF13481.6 CDL00540.1 - 0.051 13.1 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF1611 PF07755.11 CDL00540.1 - 0.089 12.1 0.6 0.24 10.7 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1611_C) P-loop domain DnaB_C PF03796.15 CDL00540.1 - 0.11 11.8 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain ParBc PF02195.18 CDL00541.1 - 3.7e-27 94.5 0.2 6.6e-27 93.6 0.2 1.4 1 0 0 1 1 1 1 ParB-like nuclease domain HTH_ParB PF17762.1 CDL00541.1 - 9.1e-15 54.2 0.1 3e-14 52.5 0.0 1.9 2 0 0 2 2 2 1 HTH domain found in ParB protein HTH_3 PF01381.22 CDL00541.1 - 0.0012 18.9 0.0 0.0036 17.3 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix TrmB PF01978.19 CDL00541.1 - 0.0017 18.2 0.0 0.0055 16.6 0.0 1.9 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB KorB PF08535.10 CDL00541.1 - 0.0021 18.0 0.1 0.33 11.0 0.0 2.6 1 1 1 2 2 2 1 KorB domain HTH_Crp_2 PF13545.6 CDL00541.1 - 0.019 15.0 0.3 0.061 13.3 0.1 2.1 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain UPF0225 PF17775.1 CDL00543.1 - 9.8e-27 93.7 0.0 1.2e-26 93.4 0.0 1.1 1 0 0 1 1 1 1 UPF0225 domain SEC-C PF02810.15 CDL00543.1 - 1e-13 50.9 26.1 3.8e-10 39.5 12.2 2.4 2 0 0 2 2 2 2 SEC-C motif Glycos_transf_2 PF00535.26 CDL00544.1 - 1.8e-23 83.2 0.0 3.5e-23 82.3 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDL00544.1 - 4.9e-09 36.4 0.0 6e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF4141 PF13605.6 CDL00544.1 - 0.02 14.1 0.0 0.038 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4141) HALZ PF02183.18 CDL00545.1 - 5.2e-05 23.4 1.3 9.5e-05 22.5 1.3 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper ZapB PF06005.12 CDL00545.1 - 0.00019 21.8 1.6 0.00028 21.3 1.6 1.3 1 0 0 1 1 1 1 Cell division protein ZapB DivIC PF04977.15 CDL00545.1 - 0.00019 21.1 3.0 0.00032 20.4 3.0 1.3 1 0 0 1 1 1 1 Septum formation initiator bZIP_1 PF00170.21 CDL00545.1 - 0.0087 16.1 2.3 0.015 15.4 2.3 1.3 1 0 0 1 1 1 1 bZIP transcription factor NRBF2 PF08961.10 CDL00545.1 - 0.017 14.7 3.7 0.026 14.2 3.4 1.3 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Shugoshin_N PF07558.11 CDL00545.1 - 0.026 14.4 1.5 0.046 13.6 1.5 1.3 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region TolA_bind_tri PF16331.5 CDL00545.1 - 0.035 14.2 1.4 0.062 13.4 1.4 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation bZIP_2 PF07716.15 CDL00545.1 - 0.036 14.2 5.3 0.066 13.3 5.3 1.5 1 0 0 1 1 1 0 Basic region leucine zipper XRCC4 PF06632.12 CDL00545.1 - 0.036 12.9 0.4 0.047 12.5 0.4 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 YabA PF06156.13 CDL00545.1 - 0.059 14.0 1.1 0.074 13.7 1.1 1.4 1 1 0 1 1 1 0 Initiation control protein YabA THOC7 PF05615.13 CDL00545.1 - 0.14 12.5 3.4 0.62 10.4 1.7 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 DUF2381 PF09544.10 CDL00545.1 - 0.14 11.6 2.8 0.19 11.2 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) Fungal_TACC PF12709.7 CDL00545.1 - 0.25 11.8 1.4 0.41 11.1 1.4 1.4 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins PikAIV_N PF18605.1 CDL00545.1 - 1.1 8.9 9.6 0.29 10.8 5.8 2.0 1 1 1 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain HATPase_c PF02518.26 CDL00546.1 - 1e-22 80.8 0.0 2e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CHASE PF03924.13 CDL00546.1 - 5.4e-12 46.0 0.7 1.1e-11 45.1 0.2 1.8 2 1 0 2 2 2 1 CHASE domain HisKA PF00512.25 CDL00546.1 - 6.5e-12 45.3 0.1 1.8e-11 43.9 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CDL00546.1 - 7.7e-06 25.8 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 GHKL domain PepSY_TM_like_2 PF16357.5 CDL00546.1 - 0.023 14.7 0.1 0.06 13.3 0.1 1.6 1 1 0 1 1 1 0 Putative PepSY_TM-like HATPase_c_3 PF13589.6 CDL00546.1 - 0.034 14.0 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Reductase_C PF14759.6 CDL00546.1 - 0.15 12.6 0.2 1.7 9.3 0.1 2.6 2 0 0 2 2 2 0 Reductase C-terminal BrnA_antitoxin PF14384.6 CDL00549.1 - 4.6e-22 78.3 0.1 6.1e-22 77.9 0.1 1.2 1 0 0 1 1 1 1 BrnA antitoxin of type II toxin-antitoxin system NTS_2 PF15448.6 CDL00549.1 - 0.15 12.5 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 N-terminal segments of P. falciparum erythrocyte membrane protein BrnT_toxin PF04365.13 CDL00550.1 - 5.1e-24 84.4 0.1 5.9e-24 84.2 0.1 1.0 1 0 0 1 1 1 1 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system Hemerythrin PF01814.23 CDL00551.1 - 5.9e-06 26.9 1.3 7.2e-06 26.7 1.3 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Utp13 PF08625.11 CDL00551.1 - 0.029 14.3 0.3 0.053 13.4 0.2 1.5 1 1 0 1 1 1 0 Utp13 specific WD40 associated domain DDE_Tnp_IS1595 PF12762.7 CDL00552.1 - 3.1e-24 85.7 0.0 6.1e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_Tnp_IS1595 PF12760.7 CDL00552.1 - 1e-10 41.4 1.0 2.3e-10 40.3 1.0 1.7 1 0 0 1 1 1 1 Transposase zinc-ribbon domain CpXC PF14353.6 CDL00552.1 - 0.013 15.6 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 CpXC protein Zn-ribbon_8 PF09723.10 CDL00552.1 - 0.17 12.0 0.7 2.6 8.2 0.0 2.8 3 0 0 3 3 3 0 Zinc ribbon domain Phage_CI_repr PF07022.13 CDL00555.1 - 0.00085 19.4 0.0 0.0012 18.9 0.0 1.2 1 0 0 1 1 1 1 Bacteriophage CI repressor helix-turn-helix domain DegQ PF08181.11 CDL00555.1 - 0.32 11.1 1.2 5.2 7.3 0.1 2.3 1 1 1 2 2 2 0 DegQ (SacQ) family DEAD PF00270.29 CDL00556.1 - 0.0002 21.2 0.0 0.00057 19.7 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 CDL00556.1 - 0.014 15.4 0.0 0.029 14.4 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain MethyltransfD12 PF02086.15 CDL00557.1 - 7.9e-16 58.5 0.0 2.5e-15 56.9 0.0 1.9 1 1 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Cons_hypoth95 PF03602.15 CDL00557.1 - 0.017 14.7 0.0 0.043 13.5 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DDE_Tnp_IS66 PF03050.14 CDL00558.1 - 2.9e-89 299.3 0.4 4.9e-89 298.6 0.0 1.6 2 0 0 2 2 2 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDL00558.1 - 2.9e-18 65.8 0.0 1e-17 64.0 0.0 2.0 1 0 0 1 1 1 1 IS66 C-terminal element LZ_Tnp_IS66 PF13007.7 CDL00558.1 - 3e-16 59.9 4.3 3e-16 59.9 4.3 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDL00558.1 - 1.5e-15 57.3 4.6 2.9e-15 56.4 4.6 1.5 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDL00558.1 - 0.18 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.12 CDL00558.1 - 1.1 10.0 3.9 11 6.8 2.2 2.9 2 1 1 3 3 3 0 SlyX TnpB_IS66 PF05717.13 CDL00559.1 - 9.3e-38 128.2 0.0 1e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein HTH_Tnp_1 PF01527.20 CDL00560.1 - 2.4e-16 59.8 0.3 3.3e-16 59.4 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDL00560.1 - 3.3e-06 26.7 0.0 5.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 CDL00560.1 - 0.0068 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 CDL00560.1 - 0.017 15.2 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 CDL00560.1 - 0.039 13.6 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain SpoVG PF04026.12 CDL00561.1 - 0.022 15.0 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 SpoVG HSDR_N_2 PF13588.6 CDL00562.1 - 5.5e-08 32.8 0.0 9.6e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) HSDR_N PF04313.14 CDL00562.1 - 1.1e-07 31.9 0.0 1.1e-05 25.5 0.0 2.1 1 1 1 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) ResIII PF04851.15 CDL00562.1 - 1.6e-06 28.3 0.0 2.8e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDL00562.1 - 0.045 13.5 0.0 0.075 12.8 0.0 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase Phage_integrase PF00589.22 CDL00563.1 - 1.1e-28 100.2 0.0 1.2e-28 100.0 0.0 1.0 1 0 0 1 1 1 1 Phage integrase family Hairy_orange PF07527.13 CDL00563.1 - 0.059 13.6 0.0 0.54 10.5 0.0 2.3 1 1 0 1 1 1 0 Hairy Orange LemA PF04011.12 CDL00564.1 - 2.4e-23 82.6 0.1 3.3e-23 82.2 0.1 1.1 1 0 0 1 1 1 1 LemA family Phage_integrase PF00589.22 CDL00567.1 - 2.4e-14 53.5 0.0 4e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Phage integrase family TPR_20 PF14561.6 CDL00568.1 - 6.7e-33 112.9 13.1 3.2e-31 107.5 4.3 2.6 3 0 0 3 3 2 2 Tetratricopeptide repeat Thioredoxin PF00085.20 CDL00568.1 - 1.4e-26 92.5 0.0 2.5e-26 91.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TPR_19 PF14559.6 CDL00568.1 - 1.6e-14 54.2 15.2 7.3e-13 48.8 0.2 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat Thioredoxin_2 PF13098.6 CDL00568.1 - 5.6e-09 36.4 0.0 2.9e-08 34.1 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain TPR_16 PF13432.6 CDL00568.1 - 2.3e-06 28.1 16.9 0.00091 19.8 0.0 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDL00568.1 - 9.2e-06 26.0 3.9 0.027 15.1 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat Thioredoxin_8 PF13905.6 CDL00568.1 - 1.7e-05 25.0 0.0 8.6e-05 22.8 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_7 PF13899.6 CDL00568.1 - 4.5e-05 23.6 0.0 0.00013 22.1 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CDL00568.1 - 6.1e-05 22.9 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family OST3_OST6 PF04756.13 CDL00568.1 - 7.3e-05 22.3 0.0 9.9e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family TPR_2 PF07719.17 CDL00568.1 - 0.00023 21.1 3.2 0.55 10.5 0.8 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat Thioredoxin_3 PF13192.6 CDL00568.1 - 0.00064 19.7 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin domain ANAPC3 PF12895.7 CDL00568.1 - 0.00066 19.9 0.6 1 9.7 0.7 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Alkyl_sulf_dimr PF14863.6 CDL00568.1 - 0.00073 20.0 2.2 0.0097 16.4 0.1 2.7 1 1 1 3 3 3 1 Alkyl sulfatase dimerisation TPR_8 PF13181.6 CDL00568.1 - 0.0011 18.9 0.4 2.1 8.8 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat PknG_TPR PF16918.5 CDL00568.1 - 0.0015 17.3 4.0 0.004 15.9 2.7 2.0 1 1 1 2 2 2 1 Protein kinase G tetratricopeptide repeat TPR_14 PF13428.6 CDL00568.1 - 0.002 18.8 17.0 0.038 14.8 0.2 4.4 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDL00568.1 - 0.0023 18.0 10.8 0.027 14.6 5.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDL00568.1 - 0.0036 16.5 6.6 0.0052 16.0 6.6 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat Thioredoxin_4 PF13462.6 CDL00568.1 - 0.006 16.8 0.2 1.9 8.6 0.0 2.9 2 2 1 3 3 3 2 Thioredoxin Redoxin PF08534.10 CDL00568.1 - 0.0085 15.8 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Redoxin Glutaredoxin PF00462.24 CDL00568.1 - 0.013 15.7 0.0 0.03 14.6 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin TraF PF13728.6 CDL00568.1 - 0.016 15.1 0.1 0.044 13.6 0.0 1.8 2 0 0 2 2 2 0 F plasmid transfer operon protein BTAD PF03704.17 CDL00568.1 - 0.021 15.3 0.2 0.021 15.3 0.2 2.4 1 1 1 2 2 2 0 Bacterial transcriptional activator domain TPR_17 PF13431.6 CDL00568.1 - 0.03 14.7 2.4 7.6 7.2 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDL00568.1 - 0.037 13.8 2.3 5.8 6.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DSBA PF01323.20 CDL00568.1 - 0.062 13.1 1.9 0.22 11.2 0.0 2.6 2 1 1 3 3 3 0 DSBA-like thioredoxin domain Thioredoxin_9 PF14595.6 CDL00568.1 - 0.068 12.9 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin DUF836 PF05768.14 CDL00568.1 - 0.091 13.2 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Alph_Pro_TM PF09608.10 CDL00568.1 - 0.11 12.3 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) TPR_7 PF13176.6 CDL00568.1 - 0.15 12.2 2.6 2.4 8.4 0.0 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat VWA_2 PF13519.6 CDL00568.1 - 0.26 12.0 1.5 6.8 7.4 0.2 2.4 2 0 0 2 2 2 0 von Willebrand factor type A domain TPR_4 PF07721.14 CDL00568.1 - 0.66 10.8 20.9 0.3 11.8 0.5 3.9 3 1 0 3 3 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDL00568.1 - 2.7 8.4 15.5 10 6.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TilS PF09179.11 CDL00568.1 - 7.9 7.1 8.9 9.4 6.8 3.5 2.9 2 2 0 2 2 2 0 TilS substrate binding domain LON_substr_bdg PF02190.16 CDL00569.1 - 1.7e-22 80.3 0.0 1.1e-21 77.7 0.0 1.8 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain Trm112p PF03966.16 CDL00570.1 - 5.8e-09 36.4 0.0 1.5e-08 35.1 0.0 1.6 1 1 0 1 1 1 1 Trm112p-like protein DUF971 PF06155.12 CDL00571.1 - 1.3e-27 96.2 0.0 1.7e-27 95.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF971) Glyco_tran_28_C PF04101.16 CDL00572.1 - 3.6e-05 23.8 0.0 6.8e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glycos_transf_1 PF00534.20 CDL00572.1 - 0.2 11.2 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 DegT_DnrJ_EryC1 PF01041.17 CDL00573.1 - 6e-114 381.1 0.0 7.3e-114 380.8 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 CDL00573.1 - 3.1e-06 26.7 0.5 4.1e-06 26.3 0.5 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CDL00573.1 - 0.00036 19.8 0.0 0.0006 19.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CDL00573.1 - 0.00068 18.7 0.3 0.00099 18.2 0.3 1.1 1 0 0 1 1 1 1 Aminotransferase class-V PALP PF00291.25 CDL00573.1 - 0.017 14.5 3.1 0.014 14.8 1.7 1.5 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme Cys_Met_Meta_PP PF01053.20 CDL00573.1 - 0.11 11.0 0.0 0.15 10.5 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Cupin_2 PF07883.11 CDL00574.1 - 6.8e-05 22.5 0.0 0.00019 21.0 0.0 1.8 1 1 0 1 1 1 1 Cupin domain DUF1971 PF09313.11 CDL00574.1 - 0.088 12.8 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1971) AbrB PF05145.12 CDL00575.1 - 1.2e-88 297.1 44.6 1.5e-88 296.8 44.6 1.1 1 0 0 1 1 1 1 Transition state regulatory protein AbrB DUF485 PF04341.12 CDL00575.1 - 0.05 13.6 0.6 0.05 13.6 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF485 NAD_kinase PF01513.21 CDL00576.1 - 2.2e-17 63.2 0.0 3.3e-17 62.6 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 CDL00576.1 - 0.0021 17.7 0.0 0.0037 16.9 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Mob_synth_C PF06463.13 CDL00577.1 - 9.2e-39 132.3 0.0 1.4e-38 131.7 0.0 1.3 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 CDL00577.1 - 2.5e-27 96.3 0.0 5.8e-27 95.1 0.0 1.6 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 CDL00577.1 - 2.2e-08 34.5 0.0 3.9e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CDL00577.1 - 2.1e-05 24.7 0.0 4.9e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain MRP-S26 PF14943.6 CDL00577.1 - 0.062 13.2 0.0 0.094 12.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Wzy_C PF04932.15 CDL00578.1 - 7.5e-09 35.4 9.8 7.5e-09 35.4 9.8 4.1 3 2 0 3 3 3 1 O-Antigen ligase Methyltr_RsmB-F PF01189.17 CDL00579.1 - 6e-41 140.3 0.0 1.1e-40 139.4 0.0 1.5 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F NusB PF01029.18 CDL00579.1 - 1.6e-24 86.6 0.0 2.3e-24 86.2 0.0 1.2 1 0 0 1 1 1 1 NusB family Methyltransf_25 PF13649.6 CDL00579.1 - 1.7e-06 28.6 0.1 3.7e-05 24.3 0.1 2.6 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDL00579.1 - 0.00017 21.2 0.0 0.0012 18.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CDL00579.1 - 0.0025 18.4 0.0 0.018 15.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDL00579.1 - 0.021 14.5 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 FtsJ PF01728.19 CDL00579.1 - 0.023 14.8 0.1 0.13 12.3 0.1 2.2 2 1 0 2 2 2 0 FtsJ-like methyltransferase PCMT PF01135.19 CDL00579.1 - 0.055 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) adh_short PF00106.25 CDL00579.1 - 0.097 12.1 0.1 0.56 9.6 0.0 2.1 2 0 0 2 2 2 0 short chain dehydrogenase Methyltransf_15 PF09445.10 CDL00579.1 - 0.099 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase TehB PF03848.14 CDL00579.1 - 0.27 10.6 0.0 0.51 9.7 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Peptidase_M48 PF01435.18 CDL00580.1 - 7.3e-37 127.0 0.3 1.7e-36 125.8 0.1 1.7 2 0 0 2 2 2 1 Peptidase family M48 Peptidase_M56 PF05569.11 CDL00580.1 - 0.00062 19.1 0.0 0.0014 17.9 0.0 1.5 1 0 0 1 1 1 1 BlaR1 peptidase M56 BSP PF04450.12 CDL00580.1 - 0.049 13.4 0.0 0.069 12.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase of plants and bacteria DUF2207 PF09972.9 CDL00580.1 - 0.93 8.2 5.0 0.84 8.3 0.1 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) ALGX PF16822.5 CDL00581.1 - 4.3e-06 26.6 0.0 1.4e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 SGNH hydrolase-like domain, acetyltransferase AlgX Lipase_GDSL_2 PF13472.6 CDL00581.1 - 0.0002 21.8 1.3 0.0056 17.1 1.3 2.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CDL00581.1 - 0.0041 17.1 0.0 0.13 12.2 0.0 2.2 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 CDL00582.1 - 7.4e-10 39.5 1.6 2.4e-08 34.6 1.6 2.2 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family ALGX PF16822.5 CDL00582.1 - 0.00021 21.1 0.0 0.00047 19.9 0.0 1.5 1 0 0 1 1 1 1 SGNH hydrolase-like domain, acetyltransferase AlgX Lipase_GDSL PF00657.22 CDL00582.1 - 0.12 12.3 0.1 2.1 8.2 0.1 2.4 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Glyco_transf_9 PF01075.17 CDL00583.1 - 1.5e-28 99.8 0.0 2.2e-28 99.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) Epimerase_2 PF02350.19 CDL00583.1 - 0.07 12.0 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase UDPG_MGDP_dh_N PF03721.14 CDL00584.1 - 1e-30 106.7 0.0 1.6e-30 106.1 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 CDL00584.1 - 6.6e-21 74.3 0.0 1.1e-20 73.6 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 CDL00584.1 - 9.6e-20 71.0 0.0 4.5e-19 68.8 0.0 2.0 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain ApbA PF02558.16 CDL00584.1 - 0.00057 19.6 0.0 0.002 17.8 0.0 1.8 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 CDL00584.1 - 0.0012 19.0 0.0 0.0055 16.9 0.0 2.1 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Glyco_transf_4 PF13439.6 CDL00584.1 - 0.078 13.0 0.0 0.51 10.3 0.0 2.3 3 0 0 3 3 3 0 Glycosyltransferase Family 4 Semialdhyde_dh PF01118.24 CDL00584.1 - 0.11 13.0 0.0 0.41 11.1 0.0 2.0 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Glyco_trans_1_4 PF13692.6 CDL00585.1 - 1.8e-24 86.7 0.0 4.2e-24 85.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDL00585.1 - 1e-23 83.7 0.0 1.5e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDL00585.1 - 1.5e-09 38.1 0.0 3.1e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDL00585.1 - 7.3e-08 32.6 0.5 1.5e-07 31.6 0.5 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CDL00585.1 - 0.00058 20.3 4.9 0.00058 20.3 4.9 2.3 3 0 0 3 3 3 1 Glycosyl transferase 4-like domain Glyco_tran_28_C PF04101.16 CDL00585.1 - 0.014 15.4 0.0 0.023 14.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.6 CDL00586.1 - 1.5e-05 25.1 2.6 0.00018 21.6 1.0 2.6 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CDL00586.1 - 0.067 13.6 21.4 0.024 15.1 13.7 2.6 1 1 1 2 2 2 0 Glycosyl transferase 4-like domain Asn_synthase PF00733.21 CDL00587.1 - 8.9e-74 249.3 0.0 1.1e-73 248.9 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CDL00587.1 - 2.4e-42 143.7 0.0 3.9e-42 143.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDL00587.1 - 2.9e-39 134.3 0.0 2.8e-38 131.1 0.0 2.2 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CDL00587.1 - 0.023 14.1 0.1 0.039 13.4 0.1 1.3 1 0 0 1 1 1 0 Aluminium induced protein NAD_synthase PF02540.17 CDL00587.1 - 0.16 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Glycos_transf_2 PF00535.26 CDL00588.1 - 6.9e-32 110.6 0.0 9.5e-32 110.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDL00588.1 - 1.9e-10 41.0 0.0 2.3e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CDL00588.1 - 2.7e-06 27.1 0.0 4.1e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CDL00588.1 - 0.00034 21.1 0.0 0.001 19.5 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CDL00588.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 Cupin_2 PF07883.11 CDL00589.1 - 1.4e-05 24.7 0.0 2.6e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CDL00589.1 - 0.023 14.4 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) 3-HAO PF06052.12 CDL00589.1 - 0.11 12.1 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase Methyltransf_14 PF08484.11 CDL00590.1 - 2.2e-54 183.6 0.0 3e-54 183.1 0.0 1.2 1 0 0 1 1 1 1 C-methyltransferase C-terminal domain Methyltransf_13 PF08421.11 CDL00590.1 - 3.8e-22 78.3 0.8 7.1e-22 77.4 0.8 1.5 1 0 0 1 1 1 1 Putative zinc binding domain Methyltransf_23 PF13489.6 CDL00590.1 - 2.8e-12 46.8 0.0 4.2e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL00590.1 - 4.5e-07 30.4 0.3 1.5e-06 28.8 0.2 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00590.1 - 8.1e-07 29.7 0.1 2e-06 28.5 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 CDL00590.1 - 0.00016 21.3 0.0 0.00028 20.5 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_25 PF13649.6 CDL00590.1 - 0.00038 21.1 1.1 0.00085 20.0 0.3 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00590.1 - 0.24 11.2 0.1 1.3 8.8 0.1 2.2 1 1 0 1 1 1 0 Methyltransferase domain Epimerase PF01370.21 CDL00591.1 - 1.5e-47 162.1 0.0 2e-47 161.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDL00591.1 - 1e-34 120.5 0.0 1.2e-34 120.2 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CDL00591.1 - 4.9e-17 61.8 0.0 9.4e-17 60.9 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CDL00591.1 - 4.5e-11 42.4 0.0 9e-09 34.9 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 CDL00591.1 - 1.2e-06 27.9 0.0 0.0069 15.6 0.0 2.3 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDL00591.1 - 6.9e-06 25.4 0.0 1.1e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain GFO_IDH_MocA PF01408.22 CDL00592.1 - 1e-16 61.8 0.0 1.5e-16 61.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CDL00592.1 - 5e-05 23.3 0.0 0.00037 20.5 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain AICARFT_IMPCHas PF01808.18 CDL00593.1 - 3.2e-117 391.2 1.2 4.2e-117 390.8 1.2 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 CDL00593.1 - 1e-26 92.9 0.0 2.2e-26 91.9 0.0 1.6 1 0 0 1 1 1 1 MGS-like domain CoA_binding_2 PF13380.6 CDL00593.1 - 0.85 10.1 4.0 10 6.6 0.1 3.6 4 0 0 4 4 4 0 CoA binding domain Glyco_trans_1_4 PF13692.6 CDL00594.1 - 2.7e-11 44.0 0.1 4.4e-11 43.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDL00594.1 - 2.9e-08 33.5 0.0 5.2e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDL00594.1 - 3e-07 30.6 0.3 6e-07 29.6 0.3 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CDL00594.1 - 0.00043 20.6 0.1 0.00081 19.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDL00594.1 - 0.002 18.6 0.5 0.002 18.6 0.5 2.1 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glycos_transf_2 PF00535.26 CDL00595.1 - 1e-10 41.7 0.0 1.6e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 CDL00595.1 - 2.1e-05 25.0 0.2 0.00012 22.5 0.2 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDL00595.1 - 0.009 15.9 0.0 0.018 15.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_1 PF00534.20 CDL00596.1 - 4.7e-32 110.9 0.0 6e-31 107.3 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDL00596.1 - 7.8e-28 97.6 0.2 1.8e-26 93.2 0.2 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDL00596.1 - 2.5e-13 50.4 2.2 6.5e-13 49.0 2.2 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CDL00596.1 - 2.5e-06 27.8 0.0 4.6e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDL00596.1 - 2.8e-05 24.6 8.0 2.8e-05 24.6 8.0 3.1 3 1 0 3 3 3 1 Glycosyl transferase 4-like domain Polysacc_deac_1 PF01522.21 CDL00597.1 - 2.3e-21 76.0 0.1 3.4e-21 75.4 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF1059 PF06348.11 CDL00597.1 - 0.9 9.8 3.5 13 6.1 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1059) Asn_synthase PF00733.21 CDL00598.1 - 8e-54 183.6 0.0 1.1e-53 183.1 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CDL00598.1 - 5e-43 145.9 0.0 8.1e-43 145.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDL00598.1 - 4.7e-40 136.9 0.1 1.7e-39 135.0 0.0 2.0 2 0 0 2 2 2 1 Glutamine amidotransferase domain NAD_synthase PF02540.17 CDL00598.1 - 0.0082 15.3 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 CDL00598.1 - 0.25 10.8 0.0 0.49 9.9 0.0 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC DUF3700 PF12481.8 CDL00598.1 - 0.25 10.7 0.0 0.58 9.6 0.0 1.5 1 1 0 1 1 1 0 Aluminium induced protein Lipase_GDSL_2 PF13472.6 CDL00600.1 - 4.4e-05 24.0 0.1 0.00042 20.8 0.0 2.5 3 1 0 3 3 3 1 GDSL-like Lipase/Acylhydrolase family ALGX PF16822.5 CDL00600.1 - 0.039 13.6 0.0 4 7.0 0.0 2.3 2 0 0 2 2 2 0 SGNH hydrolase-like domain, acetyltransferase AlgX Cyt_bd_oxida_II PF02322.15 CDL00600.1 - 0.1 12.0 9.6 0.13 11.6 9.6 1.1 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II 7TMR-DISM_7TM PF07695.11 CDL00600.1 - 0.13 12.1 3.9 0.21 11.5 3.9 1.2 1 0 0 1 1 1 0 7TM diverse intracellular signalling SIS_2 PF13580.6 CDL00601.1 - 1.4e-24 86.7 3.5 2.1e-24 86.1 3.5 1.2 1 0 0 1 1 1 1 SIS domain SIS PF01380.22 CDL00601.1 - 1.1e-10 41.4 0.1 1.1e-10 41.4 0.1 1.6 2 0 0 2 2 2 1 SIS domain Polysacc_deac_1 PF01522.21 CDL00602.1 - 6.1e-19 68.1 0.0 8.3e-19 67.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase FemAB PF02388.16 CDL00603.1 - 6.6e-11 41.7 0.0 4.3e-06 25.9 0.0 2.1 2 0 0 2 2 2 2 FemAB family Acetyltransf_6 PF13480.7 CDL00603.1 - 4.2e-10 39.9 2.7 4.2e-10 39.9 0.2 2.1 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain DegT_DnrJ_EryC1 PF01041.17 CDL00604.1 - 3.7e-05 23.2 0.0 9.3e-05 21.9 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family PALP PF00291.25 CDL00604.1 - 0.0039 16.6 0.0 0.0059 16.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Polysacc_synt_3 PF13440.6 CDL00605.1 - 6.1e-14 51.9 3.7 1.4e-13 50.7 3.7 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Polysacc_synt PF01943.17 CDL00605.1 - 1.1e-07 31.6 12.5 1.1e-07 31.6 12.5 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Glycos_transf_1 PF00534.20 CDL00606.1 - 1.8e-19 70.0 0.0 5.3e-19 68.4 0.0 1.8 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDL00606.1 - 2.3e-13 50.7 0.0 4.2e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDL00606.1 - 3.3e-12 46.6 0.0 9.6e-12 45.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDL00606.1 - 2.6e-07 31.2 1.5 2.6e-07 31.2 1.5 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CDL00606.1 - 1e-06 28.9 0.0 2.8e-06 27.4 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CDL00607.1 - 1.1e-13 51.3 0.0 7.9e-13 48.6 0.1 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDL00608.1 - 8.8e-29 100.2 0.0 1.3e-28 99.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDL00608.1 - 1.1e-24 87.4 0.8 1.5e-24 86.9 0.3 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDL00608.1 - 4.5e-07 30.4 2.3 4.5e-07 30.4 2.3 2.1 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 CDL00608.1 - 0.003 17.9 0.0 0.0081 16.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDL00609.1 - 2.3e-30 105.4 0.0 3.2e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDL00609.1 - 5e-28 98.2 0.0 8.4e-28 97.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDL00609.1 - 1.6e-11 44.4 0.0 4.5e-11 43.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDL00609.1 - 0.0001 22.4 0.3 0.0019 18.2 0.2 2.8 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CDL00609.1 - 2.6 8.5 23.7 0.045 14.2 12.2 3.0 2 2 1 3 3 3 0 Glycosyl transferase 4-like domain Glycos_transf_2 PF00535.26 CDL00610.1 - 3e-32 111.8 0.0 5.4e-32 110.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glycos_transf_1 PF00534.20 CDL00610.1 - 7.5e-32 110.2 0.0 1.4e-31 109.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDL00610.1 - 1.3e-26 93.6 0.0 6.5e-26 91.4 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_tranf_2_3 PF13641.6 CDL00610.1 - 6.7e-20 72.0 0.1 1.4e-19 70.9 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CDL00610.1 - 5.2e-15 55.7 0.0 3.5e-14 52.9 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_1_2 PF13524.6 CDL00610.1 - 2.5e-11 43.8 0.0 7.3e-11 42.3 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_2_3 PF13632.6 CDL00610.1 - 4.2e-09 36.6 1.6 6.1e-09 36.1 0.1 2.0 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 CDL00610.1 - 0.00017 21.1 0.1 0.0014 18.2 0.1 2.5 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_transf_4 PF13439.6 CDL00610.1 - 0.001 19.1 0.1 0.003 17.6 0.1 1.9 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_tranf_2_4 PF13704.6 CDL00610.1 - 0.02 15.4 2.4 0.07 13.7 2.4 1.9 1 1 0 1 1 1 0 Glycosyl transferase family 2 TPR_12 PF13424.6 CDL00610.1 - 0.028 14.7 0.1 0.11 12.8 0.1 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDL00610.1 - 1.9 9.5 5.3 1.3 10.0 0.1 3.6 3 1 0 3 3 2 0 Tetratricopeptide repeat Epimerase PF01370.21 CDL00611.1 - 1.1e-33 116.8 0.0 1.3e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDL00611.1 - 2.8e-20 73.0 0.0 4.1e-20 72.4 0.0 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CDL00611.1 - 3.3e-14 52.6 0.0 4.3e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CDL00611.1 - 5.3e-14 52.5 0.0 1.1e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CDL00611.1 - 2.6e-10 39.9 0.0 9.6e-10 38.0 0.0 1.7 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CDL00611.1 - 5.7e-07 29.0 0.0 0.00074 18.8 0.0 2.7 2 1 0 2 2 2 2 Male sterility protein NmrA PF05368.13 CDL00611.1 - 9.7e-06 25.3 0.0 1.7e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CDL00611.1 - 0.00026 20.2 0.0 0.0026 17.0 0.0 2.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DUF2336 PF10098.9 CDL00611.1 - 0.0086 15.6 3.5 0.011 15.3 0.1 2.2 2 1 0 2 2 2 1 Uncharacterised protein conserved in bacteria (DUF2336) KR PF08659.10 CDL00611.1 - 0.013 15.5 0.3 0.025 14.5 0.3 1.6 1 1 0 1 1 1 0 KR domain dTDP_sugar_isom PF00908.17 CDL00612.1 - 6.8e-11 42.1 0.0 7.9e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase GDP_Man_Dehyd PF16363.5 CDL00613.1 - 5.2e-36 124.7 0.0 1.7e-35 123.0 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDL00613.1 - 2e-31 109.3 0.0 2.5e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CDL00613.1 - 5.5e-16 58.5 0.0 6.3e-15 55.1 0.0 2.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDL00613.1 - 2e-08 33.7 0.0 3.2e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CDL00613.1 - 2.8e-07 29.8 0.0 3.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CDL00613.1 - 0.0017 17.6 0.0 0.0048 16.1 0.0 1.7 2 0 0 2 2 2 1 Male sterility protein adh_short PF00106.25 CDL00613.1 - 0.056 12.9 0.0 2 7.8 0.0 2.3 2 1 0 2 2 2 0 short chain dehydrogenase KR PF08659.10 CDL00613.1 - 0.14 12.1 0.0 0.29 11.0 0.0 1.5 1 1 0 1 1 1 0 KR domain NTP_transferase PF00483.23 CDL00614.1 - 3.6e-20 72.6 0.0 4.9e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CDL00614.1 - 8.3e-07 29.5 0.0 1.1e-06 29.0 0.0 1.4 1 1 0 1 1 1 1 MobA-like NTP transferase domain FTHFS PF01268.19 CDL00614.1 - 0.17 10.1 0.0 0.24 9.6 0.0 1.1 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase GFO_IDH_MocA PF01408.22 CDL00616.1 - 2.5e-30 105.8 0.1 3.8e-30 105.2 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 CDL00616.1 - 6.5e-05 23.4 0.0 0.00021 21.8 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 CDL00616.1 - 0.00025 21.2 0.1 0.0012 18.9 0.0 2.0 1 1 1 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 CDL00616.1 - 0.0035 17.6 0.6 0.38 11.0 0.0 3.1 2 1 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 CDL00616.1 - 0.022 15.0 0.0 0.054 13.7 0.0 1.7 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 CDL00616.1 - 0.046 13.8 0.0 0.27 11.3 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 CDL00617.1 - 2.2e-48 165.4 0.0 2.7e-48 165.1 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDL00617.1 - 8e-46 156.4 0.0 9.7e-46 156.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDL00617.1 - 1.8e-09 37.1 0.0 2.4e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CDL00617.1 - 8e-08 31.7 0.0 1.1e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CDL00617.1 - 1.8e-05 24.0 0.0 7.2e-05 22.1 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CDL00617.1 - 0.00048 19.4 0.0 0.014 14.6 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein adh_short PF00106.25 CDL00617.1 - 0.00076 19.0 0.5 0.0039 16.7 0.1 2.1 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 CDL00617.1 - 0.0022 17.9 0.0 0.0032 17.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CDL00617.1 - 0.0025 17.8 0.1 0.005 16.8 0.1 1.4 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CDL00617.1 - 0.019 15.3 0.1 0.034 14.4 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DegT_DnrJ_EryC1 PF01041.17 CDL00618.1 - 1.3e-105 353.6 0.0 1.6e-105 353.4 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CDL00618.1 - 1.1e-07 31.3 0.0 1.8e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CDL00618.1 - 0.00033 19.7 0.1 0.0005 19.1 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V PALP PF00291.25 CDL00618.1 - 0.0063 16.0 0.6 0.037 13.5 0.5 2.0 1 1 1 2 2 2 1 Pyridoxal-phosphate dependent enzyme Cys_Met_Meta_PP PF01053.20 CDL00618.1 - 0.014 13.9 0.1 0.021 13.4 0.1 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.20 CDL00618.1 - 0.053 12.2 0.0 0.08 11.7 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain HTH_24 PF13412.6 CDL00619.1 - 7.7e-09 35.0 0.3 1.4e-08 34.2 0.3 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 CDL00619.1 - 0.00037 20.3 0.1 0.00073 19.4 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 CDL00619.1 - 0.0015 18.4 0.2 0.0043 16.9 0.1 1.8 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.7 CDL00619.1 - 0.0031 17.4 0.2 0.0063 16.4 0.2 1.5 1 0 0 1 1 1 1 MarR family HTH_45 PF14947.6 CDL00619.1 - 0.02 14.8 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix EAP30 PF04157.16 CDL00619.1 - 0.022 14.0 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family Ribosomal_S25 PF03297.15 CDL00619.1 - 0.057 13.6 0.0 0.087 13.0 0.0 1.2 1 0 0 1 1 1 0 S25 ribosomal protein PEP-utilizers PF00391.23 CDL00620.1 - 1.3e-10 40.8 0.0 2.7e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain PPDK_N PF01326.19 CDL00620.1 - 1.3e-05 24.6 0.1 0.021 14.1 0.0 2.6 1 1 1 2 2 2 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain Epimerase PF01370.21 CDL00621.1 - 5e-29 101.5 0.0 6.7e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDL00621.1 - 6.4e-21 75.1 0.0 1.3e-20 74.1 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CDL00621.1 - 5.7e-10 38.7 0.0 7.8e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CDL00621.1 - 9.2e-08 32.2 0.0 2e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CDL00621.1 - 3.3e-07 29.7 0.0 5.2e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 CDL00621.1 - 2e-05 24.3 0.0 6e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 NmrA-like family Pyr_redox_2 PF07992.14 CDL00621.1 - 0.024 13.9 0.0 0.036 13.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_4 PF07993.12 CDL00621.1 - 0.062 12.5 0.3 3.4 6.8 0.0 2.5 2 1 0 2 2 2 0 Male sterility protein DegT_DnrJ_EryC1 PF01041.17 CDL00622.1 - 8.6e-91 304.9 0.0 1.8e-90 303.9 0.0 1.4 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CDL00622.1 - 0.0014 17.9 0.0 0.0022 17.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II PucR PF07905.11 CDL00622.1 - 0.022 15.0 0.0 0.054 13.8 0.0 1.6 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family Beta_elim_lyase PF01212.21 CDL00622.1 - 0.038 13.3 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Barstar PF01337.18 CDL00622.1 - 0.13 12.3 0.0 13 5.9 0.0 2.9 3 0 0 3 3 3 0 Barstar (barnase inhibitor) Epimerase_2 PF02350.19 CDL00623.1 - 1.9e-81 273.6 0.0 2.2e-81 273.4 0.0 1.0 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase NeuB PF03102.14 CDL00624.1 - 1.8e-94 315.7 0.0 2.1e-94 315.5 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.12 CDL00624.1 - 0.00026 21.6 0.0 0.00067 20.2 0.0 1.8 1 0 0 1 1 1 1 SAF domain Formyl_trans_N PF00551.19 CDL00625.1 - 1.3e-12 47.8 0.0 1.7e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 CDL00625.1 - 0.0049 17.1 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain N_formyltrans_C PF18216.1 CDL00625.1 - 0.077 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 N-formyltransferase dimerization C-terminal domain NTP_transferase PF00483.23 CDL00626.1 - 7.8e-40 137.0 0.0 9.9e-40 136.7 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CDL00626.1 - 7.4e-13 49.2 0.0 3.1e-12 47.1 0.0 1.9 2 0 0 2 2 2 1 MobA-like NTP transferase domain CBS PF00571.28 CDL00626.1 - 7.3e-08 32.7 0.6 0.0058 17.0 0.1 3.5 3 0 0 3 3 3 2 CBS domain IspD PF01128.19 CDL00626.1 - 0.008 15.9 0.0 0.15 11.7 0.0 2.2 2 0 0 2 2 2 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CheW PF01584.19 CDL00626.1 - 0.017 14.8 0.2 0.13 11.9 0.0 2.2 2 1 0 2 2 2 0 CheW-like domain GFO_IDH_MocA PF01408.22 CDL00627.1 - 6.3e-06 27.0 2.1 0.00046 21.0 0.4 3.1 2 1 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_7 PF13241.6 CDL00627.1 - 0.00029 21.2 0.1 0.00058 20.3 0.1 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding GFO_IDH_MocA_C PF02894.17 CDL00627.1 - 0.0016 18.5 0.3 0.0028 17.6 0.3 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain XdhC_C PF13478.6 CDL00627.1 - 0.0016 18.9 0.5 0.0033 17.9 0.5 1.5 1 0 0 1 1 1 1 XdhC Rossmann domain Shikimate_DH PF01488.20 CDL00627.1 - 0.0027 17.8 0.8 1.5 8.9 0.2 2.7 2 1 1 3 3 3 2 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CDL00627.1 - 0.0067 17.0 0.2 0.038 14.6 0.2 2.2 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.27 CDL00627.1 - 0.0073 16.8 0.1 0.016 15.7 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CDL00627.1 - 0.0079 15.6 0.1 0.014 14.7 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CDL00627.1 - 0.0086 16.0 0.5 0.017 15.0 0.1 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 CDL00627.1 - 0.012 15.9 3.3 0.14 12.5 0.2 2.6 2 1 0 2 2 2 0 TrkA-N domain ApbA PF02558.16 CDL00627.1 - 0.019 14.6 0.1 0.053 13.2 0.1 1.8 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 CDL00627.1 - 0.056 13.7 1.0 0.14 12.4 0.2 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain IlvN PF07991.12 CDL00627.1 - 0.084 12.4 0.2 0.2 11.2 0.2 1.8 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.14 CDL00627.1 - 0.099 12.2 0.3 0.17 11.4 0.3 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain CTP_transf_3 PF02348.19 CDL00628.1 - 4.3e-16 59.5 0.0 5.6e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 CDL00628.1 - 0.035 14.5 0.0 0.06 13.7 0.0 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain adh_short_C2 PF13561.6 CDL00629.1 - 6.4e-55 186.3 0.4 4.8e-53 180.1 0.4 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDL00629.1 - 7.8e-43 146.2 0.4 4.8e-41 140.4 0.4 2.2 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDL00629.1 - 1.1e-05 25.5 0.1 2e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 CDL00629.1 - 2.7e-05 23.3 0.6 0.00022 20.3 0.6 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CDL00629.1 - 0.0074 15.8 0.1 0.051 13.0 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family AlaDh_PNT_C PF01262.21 CDL00629.1 - 0.03 13.6 1.4 0.058 12.7 1.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain His_biosynth PF00977.21 CDL00631.1 - 4.8e-67 225.8 0.5 5.3e-67 225.6 0.5 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein DHO_dh PF01180.21 CDL00631.1 - 3.2e-11 43.0 0.3 3.4e-05 23.2 0.1 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase NMO PF03060.15 CDL00631.1 - 1e-10 41.6 2.5 5.5e-07 29.3 0.6 2.1 2 0 0 2 2 2 2 Nitronate monooxygenase Dus PF01207.17 CDL00631.1 - 1.3e-09 37.6 0.2 0.00055 19.1 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) ThiG PF05690.14 CDL00631.1 - 6.5e-09 35.5 0.5 0.00019 20.8 0.2 2.1 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 CDL00631.1 - 6.5e-08 32.1 2.4 0.00053 19.4 0.2 2.5 3 0 0 3 3 3 2 Thiamine monophosphate synthase IMPDH PF00478.25 CDL00631.1 - 1.3e-06 27.7 3.0 0.00013 21.1 0.5 2.1 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain G3P_antiterm PF04309.12 CDL00631.1 - 1.7e-06 27.6 1.0 0.024 14.1 0.1 2.2 2 0 0 2 2 2 2 Glycerol-3-phosphate responsive antiterminator FMN_dh PF01070.18 CDL00631.1 - 7.2e-06 25.3 5.7 0.00012 21.2 1.2 2.3 2 1 0 2 2 2 2 FMN-dependent dehydrogenase PcrB PF01884.17 CDL00631.1 - 8.9e-05 22.0 1.2 0.0017 17.8 0.1 2.1 2 0 0 2 2 2 1 PcrB family Glu_synthase PF01645.17 CDL00631.1 - 0.032 13.3 0.9 0.32 10.1 0.2 2.0 2 0 0 2 2 2 0 Conserved region in glutamate synthase Methyltransf_25 PF13649.6 CDL00632.1 - 1.4e-06 28.9 0.0 2.1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00632.1 - 1.3e-05 25.0 0.0 1.8e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL00632.1 - 3.6e-05 24.3 0.0 6.8e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDL00632.1 - 4.2e-05 23.0 0.0 5.7e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CDL00632.1 - 0.046 13.6 0.0 0.063 13.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 CDL00632.1 - 0.051 12.5 0.0 0.071 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) GATase PF00117.28 CDL00633.1 - 5e-19 68.8 0.0 5.7e-19 68.6 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 CDL00633.1 - 1.6e-07 31.2 0.0 2.1e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 CDL00633.1 - 5.6e-05 23.1 0.0 0.00048 20.0 0.0 2.0 2 0 0 2 2 2 1 SNO glutamine amidotransferase family Peptidase_C26 PF07722.13 CDL00633.1 - 0.046 13.5 0.0 1 9.1 0.0 2.2 2 0 0 2 2 2 0 Peptidase C26 DJ-1_PfpI PF01965.24 CDL00633.1 - 0.093 12.5 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Sulfotransfer_3 PF13469.6 CDL00634.1 - 3.8e-06 27.4 0.0 9.8e-05 22.8 0.0 2.2 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 CDL00634.1 - 0.00012 21.7 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Ribosomal_L25p PF01386.19 CDL00634.1 - 0.088 13.3 0.0 0.21 12.1 0.0 1.6 1 0 0 1 1 1 0 Ribosomal L25p family Glyco_trans_1_4 PF13692.6 CDL00635.1 - 0.043 14.3 0.0 0.081 13.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 B12-binding PF02310.19 CDL00636.1 - 8.8e-07 29.0 0.0 1.8e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 B12 binding domain Radical_SAM PF04055.21 CDL00636.1 - 1.8e-06 28.4 0.0 2.1e-05 24.9 0.0 2.8 2 1 0 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.6 CDL00636.1 - 0.018 15.2 0.0 0.18 11.9 0.0 2.6 3 0 0 3 3 3 0 4Fe-4S single cluster domain Methyltransf_25 PF13649.6 CDL00637.1 - 7.5e-18 65.0 0.1 4.4e-17 62.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL00637.1 - 6.8e-17 61.9 0.0 1.5e-16 60.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00637.1 - 3.9e-16 59.2 0.0 5.2e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL00637.1 - 9.1e-16 58.1 0.0 2.9e-15 56.5 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00637.1 - 1e-11 45.4 0.0 2.3e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 CDL00637.1 - 4.8e-05 23.4 0.0 0.00014 21.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 CDL00637.1 - 0.00012 21.4 0.0 0.00019 20.9 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CDL00637.1 - 0.00036 19.9 0.0 0.00062 19.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.6 CDL00637.1 - 0.00038 21.4 0.1 0.00093 20.2 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CDL00637.1 - 0.00049 19.7 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain TPMT PF05724.11 CDL00637.1 - 0.0033 17.1 0.0 0.0052 16.5 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) N2227 PF07942.12 CDL00637.1 - 0.049 12.8 0.0 0.093 11.9 0.0 1.4 1 0 0 1 1 1 0 N2227-like protein PCMT PF01135.19 CDL00637.1 - 0.22 11.3 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MAF_flag10 PF01973.18 CDL00639.1 - 1.6e-14 54.0 0.0 8.3e-10 38.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function DUF115 Radical_SAM PF04055.21 CDL00640.1 - 8.9e-15 55.5 0.0 4.6e-14 53.1 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily B12-binding PF02310.19 CDL00640.1 - 1.3e-12 47.8 0.0 2.2e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 B12 binding domain Methyltransf_25 PF13649.6 CDL00641.1 - 0.0019 18.9 0.0 0.0047 17.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ABC_tran PF00005.27 CDL00642.1 - 5.3e-32 111.2 0.0 7.9e-32 110.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDL00642.1 - 7.4e-12 45.5 9.0 1.1e-11 44.9 9.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDL00642.1 - 2.3e-07 30.5 2.1 1.7e-06 27.7 2.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDL00642.1 - 0.0016 18.2 0.1 0.0038 16.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDL00642.1 - 0.023 14.6 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase DUF87 PF01935.17 CDL00642.1 - 0.024 14.7 0.2 0.054 13.6 0.2 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain ABC_ATPase PF09818.9 CDL00642.1 - 0.049 12.4 1.3 0.3 9.8 0.1 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_21 PF13304.6 CDL00642.1 - 0.1 12.4 1.7 0.8 9.4 0.4 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDL00642.1 - 0.22 11.9 2.7 0.93 9.9 2.8 2.1 1 1 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 CDL00642.1 - 2.2 8.6 7.2 0.83 9.9 1.5 3.1 3 1 0 3 3 3 0 Putative exonuclease SbcCD, C subunit YbhQ PF11076.8 CDL00642.1 - 6.1 6.9 10.4 2.8 7.9 5.9 2.5 2 1 0 2 2 2 0 Putative inner membrane protein YbhQ Peptidase_C26 PF07722.13 CDL00643.1 - 1.6e-22 80.4 0.0 2.7e-21 76.3 0.0 2.3 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 CDL00643.1 - 7.3e-06 25.9 0.0 9e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 CDL00643.1 - 0.0077 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 CDL00643.1 - 0.043 13.6 0.0 0.058 13.2 0.0 1.1 1 0 0 1 1 1 0 DJ-1/PfpI family NTP_transf_3 PF12804.7 CDL00644.1 - 3.3e-16 60.1 0.0 3.5e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 CDL00644.1 - 1.1e-10 41.6 0.0 4.4e-10 39.5 0.0 1.9 2 1 0 2 2 2 1 Nucleotidyl transferase IspD PF01128.19 CDL00644.1 - 3.6e-05 23.6 0.0 5.7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Sulfatase PF00884.23 CDL00645.1 - 4.9e-36 124.7 0.0 1.3e-23 83.9 0.0 2.1 2 0 0 2 2 2 2 Sulfatase Phosphodiest PF01663.22 CDL00645.1 - 4.7e-08 33.0 0.1 0.0035 17.0 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 CDL00645.1 - 5.8e-05 22.6 0.0 0.00016 21.1 0.0 1.7 2 0 0 2 2 2 1 Metalloenzyme superfamily APS_kinase PF01583.20 CDL00646.1 - 4.2e-30 104.7 0.0 5.2e-30 104.4 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 CDL00646.1 - 1.8e-06 28.2 0.0 2.4e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CDL00646.1 - 6.5e-05 22.3 0.0 8.3e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.6 CDL00646.1 - 7.6e-05 23.3 0.1 0.00015 22.3 0.0 1.5 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 CDL00646.1 - 0.0035 17.0 0.0 0.0058 16.3 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 CDL00646.1 - 0.0099 16.3 0.1 0.013 15.9 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.6 CDL00646.1 - 0.011 16.2 0.0 0.017 15.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDL00646.1 - 0.011 15.7 0.1 0.023 14.6 0.1 1.5 1 1 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 CDL00646.1 - 0.011 16.0 0.0 0.017 15.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDL00646.1 - 0.011 15.5 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDL00646.1 - 0.022 14.5 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 CDL00646.1 - 0.041 13.6 0.0 0.055 13.2 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ABC_tran PF00005.27 CDL00646.1 - 0.064 13.8 0.0 0.076 13.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA PF00004.29 CDL00646.1 - 0.083 13.3 0.0 0.23 11.9 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SKI PF01202.22 CDL00646.1 - 0.1 12.7 0.1 0.31 11.1 0.1 1.9 1 1 0 1 1 1 0 Shikimate kinase Formyl_trans_N PF00551.19 CDL00648.1 - 2.6e-07 30.6 0.0 2.7e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase B12-binding PF02310.19 CDL00648.1 - 0.089 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 B12 binding domain Methyltransf_23 PF13489.6 CDL00649.1 - 5.8e-18 65.3 0.1 1.8e-17 63.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL00649.1 - 1.6e-09 38.2 0.6 7.6e-09 36.1 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00649.1 - 2e-09 37.4 0.1 5.4e-09 36.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00649.1 - 3.3e-07 31.0 0.0 8.8e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL00649.1 - 2e-06 28.4 1.0 4.2e-06 27.4 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase domain MetW PF07021.12 CDL00649.1 - 0.2 11.3 0.0 0.41 10.2 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW zf-TFIIB PF13453.6 CDL00649.1 - 0.85 9.0 5.6 1.9 7.9 5.6 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger ParD_like PF11903.8 CDL00650.1 - 0.01 15.9 0.0 0.036 14.1 0.0 2.0 2 0 0 2 2 2 1 ParD-like antitoxin of type II bacterial toxin-antitoxin system HpcH_HpaI PF03328.14 CDL00651.1 - 5.6e-35 120.5 0.0 9e-35 119.8 0.0 1.3 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family CTP_transf_3 PF02348.19 CDL00651.1 - 4.4e-31 108.5 0.0 7.5e-31 107.8 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 CDL00651.1 - 1.2e-10 42.0 0.3 1.2e-10 42.0 0.3 2.4 2 1 0 2 2 2 1 MobA-like NTP transferase domain GFO_IDH_MocA PF01408.22 CDL00652.1 - 4.8e-16 59.7 0.0 1.1e-15 58.5 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CDL00652.1 - 1.5e-05 25.0 0.1 2.6e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain ox_reductase_C PF08635.10 CDL00652.1 - 0.0014 18.3 0.0 0.0058 16.3 0.0 1.9 1 1 1 2 2 2 1 Putative oxidoreductase C terminal domain Semialdhyde_dh PF01118.24 CDL00652.1 - 0.021 15.3 0.0 0.047 14.1 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Lipase_GDSL_2 PF13472.6 CDL00653.1 - 0.0023 18.4 0.0 0.011 16.1 0.0 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family ALGX PF16822.5 CDL00653.1 - 0.007 16.1 0.0 0.17 11.6 0.0 2.3 2 0 0 2 2 2 1 SGNH hydrolase-like domain, acetyltransferase AlgX Lipase_GDSL PF00657.22 CDL00653.1 - 0.035 14.1 0.0 0.58 10.1 0.0 2.1 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase HAD_2 PF13419.6 CDL00654.1 - 1.9e-25 90.0 0.0 2.2e-25 89.8 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDL00654.1 - 3e-18 66.9 0.0 3.7e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDL00654.1 - 2.3e-15 57.5 0.1 3.1e-15 57.1 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDL00654.1 - 2.6e-07 30.6 0.1 6.7e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 CDL00654.1 - 0.052 13.7 0.0 0.71 10.0 0.0 2.3 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDL00654.1 - 0.11 12.3 0.0 12 5.5 0.0 2.8 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase 2-Hacid_dh_C PF02826.19 CDL00655.1 - 1.3e-52 177.8 0.0 1.7e-52 177.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDL00655.1 - 3.1e-15 56.0 0.0 3.9e-15 55.7 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.21 CDL00655.1 - 0.027 14.5 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Glycos_transf_2 PF00535.26 CDL00660.1 - 1.7e-24 86.5 0.0 2.4e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Phage_holin_3_6 PF07332.11 CDL00660.1 - 0.037 14.1 3.2 0.077 13.0 3.2 1.5 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2975 PF11188.8 CDL00660.1 - 0.064 13.1 1.3 0.14 12.1 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) Hexapep PF00132.24 CDL00661.1 - 3.2e-15 55.2 10.0 2.1e-09 36.7 2.0 3.1 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDL00661.1 - 6.2e-15 54.7 7.8 6.2e-08 32.3 1.0 2.5 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 CDL00662.1 - 1.1e-24 85.1 17.1 7.8e-11 41.3 3.0 4.1 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDL00662.1 - 2.5e-21 75.1 17.2 7.7e-09 35.2 4.0 4.1 4 1 0 4 4 4 3 Hexapeptide repeat of succinyl-transferase DegT_DnrJ_EryC1 PF01041.17 CDL00663.1 - 7.9e-103 344.5 0.0 8.9e-103 344.3 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CDL00663.1 - 2.4e-06 27.0 0.0 1.5e-05 24.4 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CDL00663.1 - 0.0001 21.7 0.0 0.00022 20.6 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase HTH_23 PF13384.6 CDL00664.1 - 0.00024 20.8 0.2 0.00037 20.2 0.2 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 CDL00664.1 - 0.0067 16.5 0.2 0.0093 16.1 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 CDL00664.1 - 0.027 13.9 0.0 0.046 13.1 0.0 1.4 1 1 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_29 PF13551.6 CDL00664.1 - 0.042 13.9 0.1 0.056 13.5 0.1 1.2 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_1 PF01527.20 CDL00664.1 - 0.1 12.9 0.2 0.17 12.3 0.2 1.3 1 0 0 1 1 1 0 Transposase HTH_32 PF13565.6 CDL00666.1 - 0.00019 22.0 0.3 0.00035 21.1 0.3 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_23 PF13384.6 CDL00666.1 - 0.022 14.5 0.2 0.043 13.6 0.2 1.6 1 1 0 1 1 1 0 Homeodomain-like domain DDE_3 PF13358.6 CDL00667.1 - 5.9e-31 107.2 0.0 8.2e-31 106.7 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease Cupin_5 PF06172.11 CDL00667.1 - 0.099 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily (DUF985) Transposase_mut PF00872.18 CDL00668.1 - 2.6e-108 362.3 0.1 3e-108 362.1 0.1 1.0 1 0 0 1 1 1 1 Transposase, Mutator family MULE PF10551.9 CDL00668.1 - 4.3e-08 33.5 0.0 8.7e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.17 CDL00668.1 - 0.0007 19.4 0.0 0.93 9.2 0.0 2.2 1 1 1 2 2 2 2 Transposase Creatininase PF02633.14 CDL00668.1 - 0.0019 17.7 0.0 0.003 17.1 0.0 1.3 1 0 0 1 1 1 1 Creatinine amidohydrolase DDE_Tnp_IS240 PF13610.6 CDL00668.1 - 0.16 12.2 1.2 7.8 6.7 0.6 2.8 1 1 0 1 1 1 0 DDE domain Wzy_C PF04932.15 CDL00671.1 - 2.5e-09 36.9 0.1 2.5e-09 36.9 0.1 4.5 3 2 1 4 4 4 2 O-Antigen ligase Epimerase_2 PF02350.19 CDL00672.1 - 5.3e-100 334.6 0.0 6.1e-100 334.4 0.0 1.0 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase Glyco_trans_4_4 PF13579.6 CDL00672.1 - 0.0094 16.4 1.2 0.24 11.8 0.1 2.8 2 2 0 3 3 3 1 Glycosyl transferase 4-like domain Pyr_redox PF00070.27 CDL00672.1 - 0.082 13.5 0.0 0.38 11.3 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GFO_IDH_MocA PF01408.22 CDL00673.1 - 6.7e-18 65.7 4.5 8.2e-18 65.4 0.1 3.1 4 1 0 4 4 4 1 Oxidoreductase family, NAD-binding Rossmann fold ADH_zinc_N PF00107.26 CDL00673.1 - 3.3e-15 56.2 0.4 1.1e-14 54.5 0.2 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase TrkA_N PF02254.18 CDL00673.1 - 8.4e-05 22.8 1.7 0.00031 21.0 0.7 2.4 2 0 0 2 2 2 1 TrkA-N domain 2-Hacid_dh_C PF02826.19 CDL00673.1 - 0.0002 20.8 0.2 0.039 13.3 0.1 2.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CDL00673.1 - 0.00035 20.5 0.7 0.0011 18.8 0.7 1.9 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 CDL00673.1 - 0.0012 19.5 1.0 0.0031 18.2 0.1 2.2 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CDL00673.1 - 0.0012 18.4 0.1 0.0024 17.5 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 CDL00673.1 - 0.0033 17.1 0.4 0.0082 15.8 0.4 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 CDL00673.1 - 0.0097 15.2 1.4 0.023 14.0 1.4 1.6 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 CDL00673.1 - 0.0099 15.2 2.8 0.0099 15.2 2.8 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain GFO_IDH_MocA_C PF02894.17 CDL00673.1 - 0.13 12.2 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain XdhC_C PF13478.6 CDL00673.1 - 0.14 12.6 1.5 0.43 11.1 0.2 2.3 2 0 0 2 2 2 0 XdhC Rossmann domain CbiA PF01656.23 CDL00673.1 - 0.16 12.1 0.0 0.57 10.3 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Glycos_transf_4 PF00953.21 CDL00674.1 - 1.6e-24 86.7 10.8 1.6e-24 86.7 10.8 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 4 DUF412 PF04217.13 CDL00674.1 - 0.32 10.9 1.1 0.63 9.9 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF412 Epimerase PF01370.21 CDL00675.1 - 4.2e-27 95.2 0.0 5.1e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDL00675.1 - 1.3e-18 67.1 0.0 1.6e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 CDL00675.1 - 2.4e-18 66.7 0.1 3.1e-18 66.3 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CDL00675.1 - 2.8e-17 62.7 0.0 1e-10 41.3 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 CDL00675.1 - 8.7e-17 61.0 0.0 1.3e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CDL00675.1 - 3.8e-13 49.5 0.0 1.7e-11 44.1 0.0 2.6 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CDL00675.1 - 1.7e-07 30.7 0.0 0.00049 19.3 0.0 3.2 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein NmrA PF05368.13 CDL00675.1 - 1.6e-05 24.6 0.1 0.00014 21.5 0.1 2.2 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CDL00675.1 - 0.15 11.5 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Hpr_kinase_C PF07475.12 CDL00675.1 - 0.24 10.9 0.2 0.42 10.1 0.2 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain NTP_transferase PF00483.23 CDL00676.1 - 1.2e-67 228.1 0.0 2.8e-67 226.9 0.0 1.6 2 0 0 2 2 2 1 Nucleotidyl transferase MannoseP_isomer PF01050.18 CDL00676.1 - 1.3e-66 223.2 0.3 3e-66 222.0 0.3 1.6 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.11 CDL00676.1 - 1.2e-11 44.2 0.1 2.7e-11 43.0 0.1 1.7 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CDL00676.1 - 4.7e-06 26.5 0.0 1.2e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 AraC-like ligand binding domain NTP_transf_3 PF12804.7 CDL00676.1 - 5.6e-06 26.8 6.7 1.8e-05 25.2 1.4 3.1 1 1 2 3 3 3 1 MobA-like NTP transferase domain Cupin_6 PF12852.7 CDL00676.1 - 0.0036 17.0 1.2 1.3 8.7 0.0 3.2 2 1 1 3 3 3 1 Cupin DUF218 PF02698.17 CDL00676.1 - 0.0096 15.9 0.1 0.033 14.2 0.1 2.1 1 1 0 1 1 1 1 DUF218 domain Radical_SAM PF04055.21 CDL00677.1 - 1.9e-18 67.4 0.0 3.7e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily B12-binding PF02310.19 CDL00677.1 - 3.9e-18 65.6 0.0 2.3e-17 63.2 0.0 2.0 2 0 0 2 2 2 1 B12 binding domain Asn_synthase PF00733.21 CDL00678.1 - 3.7e-81 273.5 0.1 5.1e-81 273.1 0.1 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CDL00678.1 - 3.3e-42 143.3 0.0 4.9e-42 142.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDL00678.1 - 3.8e-39 133.9 0.0 9.2e-39 132.7 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain QueC PF06508.13 CDL00678.1 - 0.0015 18.1 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC NAD_synthase PF02540.17 CDL00678.1 - 0.0018 17.4 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 NAD synthase DUF3700 PF12481.8 CDL00678.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 Aluminium induced protein tRNA_Me_trans PF03054.16 CDL00678.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Glycos_transf_2 PF00535.26 CDL00679.1 - 1.4e-27 96.5 0.0 2e-27 96.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDL00679.1 - 3.4e-07 30.4 0.0 4.2e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CDL00679.1 - 0.0095 15.4 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CDL00679.1 - 0.013 16.0 0.0 0.023 15.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 BssC_TutF PF08201.11 CDL00681.1 - 0.0088 16.0 0.2 0.01 15.9 0.2 1.1 1 0 0 1 1 1 1 BssC/TutF protein Carbam_trans_N PF02543.15 CDL00682.1 - 2.7e-106 356.1 0.0 3.3e-106 355.8 0.0 1.1 1 0 0 1 1 1 1 Carbamoyltransferase N-terminus Carbam_trans_C PF16861.5 CDL00682.1 - 1.4e-75 252.6 0.0 1.1e-74 249.6 0.0 2.1 2 0 0 2 2 2 1 Carbamoyltransferase C-terminus Peptidase_M22 PF00814.25 CDL00682.1 - 0.00019 21.2 0.0 0.0098 15.6 0.0 2.3 2 0 0 2 2 2 1 Glycoprotease family Sua5_yciO_yrdC PF01300.18 CDL00682.1 - 0.15 11.5 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 Telomere recombination Wzy_C PF04932.15 CDL00683.1 - 0.1 12.3 2.9 0.1 12.2 2.9 1.0 1 0 0 1 1 1 0 O-Antigen ligase SIS_2 PF13580.6 CDL00685.1 - 3.4e-27 95.1 0.5 4.1e-27 94.9 0.5 1.1 1 0 0 1 1 1 1 SIS domain SIS PF01380.22 CDL00685.1 - 6.3e-08 32.5 0.1 6e-06 26.1 0.0 2.4 2 0 0 2 2 2 2 SIS domain Bac_GDH PF05088.12 CDL00686.1 - 0 2078.5 0.0 0 2078.3 0.0 1.0 1 0 0 1 1 1 1 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog PF00208.21 CDL00686.1 - 9.3e-05 22.3 0.1 0.00059 19.6 0.0 2.0 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase DNA_pol3_delta PF06144.13 CDL00687.1 - 4.7e-10 39.5 0.0 6.9e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DNA_pol3_gamma3 PF12169.8 CDL00687.1 - 0.077 12.9 0.5 1.9 8.4 0.1 2.4 2 0 0 2 2 2 0 DNA polymerase III subunits gamma and tau domain III LptE PF04390.12 CDL00688.1 - 4.2e-08 33.8 0.4 5.8e-08 33.4 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide-assembly LPAM_2 PF13627.6 CDL00688.1 - 1.9 8.4 5.1 2.9 7.8 5.1 1.3 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site tRNA-synt_1_2 PF13603.6 CDL00689.1 - 6e-68 228.0 0.0 9e-68 227.4 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1 PF00133.22 CDL00689.1 - 1.9e-63 214.7 0.0 1.5e-24 86.3 0.3 6.0 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CDL00689.1 - 4.6e-31 107.9 0.0 2.3e-20 72.7 0.0 4.3 3 1 1 4 4 4 4 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CDL00689.1 - 1.2e-19 70.8 0.0 1.9e-18 66.9 0.0 2.2 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1f PF01921.18 CDL00689.1 - 5.3e-05 22.3 0.0 0.31 9.9 0.0 3.0 3 0 0 3 3 3 2 tRNA synthetases class I (K) tRNA-synt_1e PF01406.19 CDL00689.1 - 8.9e-05 22.0 0.0 0.28 10.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain DUF3576 PF12100.8 CDL00690.1 - 4.6e-45 151.9 0.0 5.6e-45 151.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3576) DUF5550 PF17704.1 CDL00690.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5550) Glyco_transf_8 PF01501.20 CDL00691.1 - 0.0016 18.1 0.2 0.0028 17.3 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 8 TPR_2 PF07719.17 CDL00692.1 - 6.5e-19 66.5 11.1 1.9e-06 27.6 0.0 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDL00692.1 - 1e-14 54.9 24.0 2.4e-11 44.1 1.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDL00692.1 - 1.3e-14 54.4 15.7 4.6e-09 36.7 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDL00692.1 - 1.8e-14 52.7 2.3 0.00023 21.2 0.0 5.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDL00692.1 - 2.7e-14 52.3 5.9 6e-05 22.7 0.0 4.8 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDL00692.1 - 1e-12 47.7 22.6 0.00014 22.4 0.7 5.2 3 1 2 5 5 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDL00692.1 - 1.8e-11 44.1 18.2 0.00052 20.3 0.0 5.6 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_10 PF13374.6 CDL00692.1 - 4.8e-09 35.8 21.7 0.0029 17.4 0.3 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDL00692.1 - 9.5e-09 34.8 2.5 0.11 12.2 0.1 4.5 2 1 2 4 4 4 3 TPR repeat ANAPC3 PF12895.7 CDL00692.1 - 7.4e-07 29.3 2.9 0.014 15.6 0.1 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CDL00692.1 - 1.4e-05 25.1 8.1 0.43 11.1 0.0 4.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDL00692.1 - 2.6e-05 23.9 10.0 0.073 13.1 0.0 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 CDL00692.1 - 0.00021 20.6 6.4 0.0017 17.6 4.0 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat Glyco_transf_9 PF01075.17 CDL00692.1 - 0.0011 18.3 0.0 0.0018 17.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) TPR_4 PF07721.14 CDL00692.1 - 0.026 15.1 2.7 0.026 15.1 2.7 7.2 8 0 0 8 8 7 0 Tetratricopeptide repeat NARP1 PF12569.8 CDL00692.1 - 0.072 12.0 0.1 0.17 10.7 0.1 1.4 1 1 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 CDL00692.1 - 0.12 12.5 19.0 0.051 13.7 1.6 3.8 2 1 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDL00692.1 - 0.13 12.3 0.3 1.2 9.3 0.1 2.7 3 0 0 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 CDL00692.1 - 0.46 11.2 6.2 37 5.2 0.6 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 CDL00692.1 - 0.65 9.9 3.7 1.6 8.6 1.9 2.3 1 1 1 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal Porin_4 PF13609.6 CDL00694.1 - 2e-53 182.2 43.8 2.7e-53 181.8 43.8 1.1 1 0 0 1 1 1 1 Gram-negative porin Porin_4 PF13609.6 CDL00695.1 - 1.5e-49 169.4 38.2 2.2e-49 168.9 38.2 1.2 1 0 0 1 1 1 1 Gram-negative porin TMP-TENI PF02581.17 CDL00696.1 - 2.1e-23 82.6 0.0 2.3e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Thiamine monophosphate synthase Ala_racemase_N PF01168.20 CDL00697.1 - 5e-21 75.3 0.0 6.1e-21 75.1 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain YkuD PF03734.14 CDL00698.1 - 4.1e-10 40.2 0.0 4.8e-10 40.0 0.0 1.0 1 0 0 1 1 1 1 L,D-transpeptidase catalytic domain TFIIA PF03153.13 CDL00699.1 - 0.58 10.1 3.4 0.61 10.0 3.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM70 PF14967.6 CDL00699.1 - 2.6 7.4 5.0 3.6 7.0 5.0 1.3 1 0 0 1 1 1 0 FAM70 protein GTP_cyclohydro2 PF00925.20 CDL00700.1 - 3.3e-58 195.9 0.0 5.4e-58 195.2 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II TusA PF01206.17 CDL00700.1 - 0.067 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Sulfurtransferase TusA DHBP_synthase PF00926.19 CDL00700.1 - 0.49 9.9 2.1 0.54 9.7 0.0 1.9 2 0 0 2 2 2 0 3,4-dihydroxy-2-butanone 4-phosphate synthase Trans_reg_C PF00486.28 CDL00701.1 - 7.1e-19 67.7 0.0 1.5e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 CDL00701.1 - 0.00072 19.7 0.1 0.0027 17.8 0.1 1.9 2 0 0 2 2 2 1 Response regulator receiver domain GerE PF00196.19 CDL00701.1 - 0.092 12.3 0.0 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Asn_synthase PF00733.21 CDL00702.1 - 1.7e-85 287.8 0.2 2.1e-85 287.5 0.2 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 CDL00702.1 - 2.4e-41 140.5 0.0 4.2e-41 139.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDL00702.1 - 3.7e-41 140.5 0.0 9.3e-41 139.2 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CDL00702.1 - 0.005 16.3 0.0 0.0083 15.6 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 CDL00702.1 - 0.014 14.5 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 NAD synthase tRNA_Me_trans PF03054.16 CDL00702.1 - 0.07 11.9 0.0 0.098 11.4 0.0 1.1 1 0 0 1 1 1 0 tRNA methyl transferase HIT PF01230.23 CDL00703.1 - 1.1e-26 93.4 0.0 1.3e-26 93.2 0.0 1.0 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CDL00703.1 - 1.6e-14 54.4 0.0 1.9e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding PRA-PH PF01503.17 CDL00704.1 - 7.8e-19 67.9 0.0 8.9e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 CDL00704.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain Methyltransf_23 PF13489.6 CDL00705.1 - 1.7e-07 31.2 0.0 2.3e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00705.1 - 0.00023 21.0 0.0 0.027 14.3 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 CDL00705.1 - 0.00033 21.3 0.0 0.3 11.8 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00705.1 - 0.0026 18.5 0.1 0.1 13.4 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 CDL00705.1 - 0.18 11.8 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain His_biosynth PF00977.21 CDL00706.1 - 1.7e-91 305.8 1.0 1.9e-91 305.6 1.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein NMO PF03060.15 CDL00706.1 - 1.5e-05 24.6 3.4 0.0061 16.0 1.4 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase ThiG PF05690.14 CDL00706.1 - 8.6e-05 22.0 3.0 0.01 15.1 0.7 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 CDL00706.1 - 0.00062 19.0 0.1 0.083 12.0 0.0 2.1 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) G3P_antiterm PF04309.12 CDL00706.1 - 0.0015 17.9 0.2 0.1 12.0 0.0 2.2 2 0 0 2 2 2 1 Glycerol-3-phosphate responsive antiterminator IMPDH PF00478.25 CDL00706.1 - 0.0022 17.1 2.8 0.48 9.4 0.1 2.2 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain DHO_dh PF01180.21 CDL00706.1 - 0.0026 17.0 0.2 1 8.5 0.1 2.2 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase TMP-TENI PF02581.17 CDL00706.1 - 0.0064 15.8 0.3 1.5 8.1 0.1 2.5 2 1 0 2 2 2 2 Thiamine monophosphate synthase FMN_dh PF01070.18 CDL00706.1 - 1.2 8.1 6.1 0.41 9.6 0.2 2.5 1 1 2 3 3 3 0 FMN-dependent dehydrogenase His_biosynth PF00977.21 CDL00707.1 - 1.1e-77 260.6 2.1 1.2e-77 260.5 2.1 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.17 CDL00707.1 - 2.9e-10 39.8 0.8 0.00042 19.5 0.1 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.15 CDL00707.1 - 0.0023 17.4 7.6 0.054 12.9 0.4 2.1 2 0 0 2 2 2 2 Nitronate monooxygenase DeoC PF01791.9 CDL00707.1 - 0.0093 15.6 0.2 0.02 14.5 0.2 1.6 1 0 0 1 1 1 1 DeoC/LacD family aldolase DUF561 PF04481.12 CDL00707.1 - 0.025 13.8 1.0 0.34 10.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF561) G3P_antiterm PF04309.12 CDL00707.1 - 0.03 13.8 0.5 4.3 6.7 0.0 2.2 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator TMP-TENI PF02581.17 CDL00707.1 - 0.031 13.6 3.4 0.54 9.6 0.3 2.3 2 0 0 2 2 2 0 Thiamine monophosphate synthase ThiG PF05690.14 CDL00707.1 - 0.81 8.9 7.7 0.87 8.8 0.9 2.2 1 1 2 3 3 3 0 Thiazole biosynthesis protein ThiG NeuB PF03102.14 CDL00708.1 - 3.4e-77 259.2 0.0 4e-77 258.9 0.0 1.1 1 0 0 1 1 1 1 NeuB family SAF PF08666.12 CDL00708.1 - 1e-05 26.0 1.1 7.9e-05 23.2 0.4 2.5 2 0 0 2 2 2 1 SAF domain DnaB_2 PF07261.11 CDL00708.1 - 0.15 11.8 0.0 5.4 6.8 0.0 2.5 2 0 0 2 2 2 0 Replication initiation and membrane attachment GATase PF00117.28 CDL00709.1 - 6.3e-18 65.2 0.0 7.3e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CDL00709.1 - 0.0002 21.2 0.2 0.0069 16.2 0.1 2.1 2 0 0 2 2 2 1 Peptidase C26 SNO PF01174.19 CDL00709.1 - 0.001 18.9 0.0 0.4 10.5 0.0 2.2 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 CDL00709.1 - 0.0045 16.6 0.0 0.009 15.6 0.0 1.5 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain UPRTase PF14681.6 CDL00709.1 - 0.062 12.7 0.0 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase GATase_5 PF13507.6 CDL00709.1 - 0.13 11.4 0.1 0.21 10.6 0.1 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 CDL00709.1 - 0.15 11.9 0.1 0.21 11.4 0.1 1.2 1 0 0 1 1 1 0 DJ-1/PfpI family IGPD PF00475.18 CDL00710.1 - 1.2e-67 226.7 0.5 1.7e-67 226.2 0.4 1.3 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase Proteasome PF00227.26 CDL00711.1 - 1.1e-20 74.0 1.6 3.3e-20 72.4 1.6 1.6 1 1 0 1 1 1 1 Proteasome subunit DUF4191 PF13829.6 CDL00711.1 - 0.0068 15.8 0.1 0.0095 15.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4191) AAA_2 PF07724.14 CDL00712.1 - 1e-44 152.7 0.0 4.9e-37 127.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 CDL00712.1 - 1.1e-13 51.7 0.0 3.2e-05 24.4 0.0 2.9 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDL00712.1 - 3.6e-07 30.3 0.1 1.9e-05 24.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDL00712.1 - 5.7e-06 26.8 2.4 0.00022 21.6 0.4 2.5 2 1 0 2 2 2 1 AAA ATPase domain ClpB_D2-small PF10431.9 CDL00712.1 - 2e-05 24.6 2.2 0.00017 21.6 0.2 2.7 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein RuvB_N PF05496.12 CDL00712.1 - 3.1e-05 23.8 0.2 0.0023 17.7 0.1 2.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDL00712.1 - 9.5e-05 21.9 0.0 0.0065 15.9 0.0 3.0 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CDL00712.1 - 0.00023 21.5 0.1 0.001 19.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain MCM PF00493.23 CDL00712.1 - 0.00024 20.3 0.0 0.0061 15.7 0.0 2.2 2 0 0 2 2 2 1 MCM P-loop domain Sigma54_activat PF00158.26 CDL00712.1 - 0.0016 18.2 0.0 0.067 12.9 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_18 PF13238.6 CDL00712.1 - 0.0058 17.2 0.0 0.013 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CDL00712.1 - 0.0061 16.5 0.1 2.9 7.8 0.0 2.9 3 0 0 3 3 3 1 NACHT domain AAA_28 PF13521.6 CDL00712.1 - 0.011 16.0 0.0 0.026 14.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDL00712.1 - 0.013 15.6 0.0 0.033 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 CDL00712.1 - 0.018 14.2 0.1 0.05 12.8 0.0 1.7 1 1 1 2 2 2 0 TIP49 P-loop domain AAA_3 PF07726.11 CDL00712.1 - 0.024 14.5 0.1 9.4 6.1 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CDL00712.1 - 0.036 13.4 0.1 0.074 12.3 0.1 1.5 1 1 0 1 1 1 0 Zeta toxin IstB_IS21 PF01695.17 CDL00712.1 - 0.045 13.5 0.0 0.097 12.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 CDL00712.1 - 0.046 13.4 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 CDL00712.1 - 0.052 13.0 0.0 0.13 11.6 0.0 1.8 1 1 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 CDL00712.1 - 0.11 13.1 0.0 0.23 12.0 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 CDL00712.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DEAD PF00270.29 CDL00712.1 - 0.16 11.7 0.1 0.73 9.6 0.0 2.1 2 1 0 2 2 2 0 DEAD/DEAH box helicase ATP-synt_ab PF00006.25 CDL00712.1 - 0.17 11.5 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain cNMP_binding PF00027.29 CDL00713.1 - 4.9e-13 49.0 0.0 9.2e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain HTH_Crp_2 PF13545.6 CDL00713.1 - 1.3e-05 25.1 0.2 4.6e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain TrmB PF01978.19 CDL00713.1 - 0.053 13.4 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 CDL00713.1 - 0.057 13.5 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain MarR PF01047.22 CDL00713.1 - 0.062 13.2 0.0 2 8.4 0.0 2.2 2 0 0 2 2 2 0 MarR family GntR PF00392.21 CDL00713.1 - 0.067 12.8 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family MarR_2 PF12802.7 CDL00713.1 - 0.069 13.0 3.2 0.42 10.5 0.1 2.6 3 0 0 3 3 3 0 MarR family HTH_31 PF13560.6 CDL00715.1 - 6e-09 36.1 0.0 1.1e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CDL00715.1 - 1.5e-07 31.3 0.0 3e-07 30.4 0.0 1.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 CDL00715.1 - 9.5e-06 25.6 0.0 1.9e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_25 PF13413.6 CDL00715.1 - 0.00028 20.7 0.0 0.00072 19.4 0.0 1.8 1 1 0 1 1 1 1 Helix-turn-helix domain Smr PF01713.21 CDL00716.1 - 1.6e-23 82.9 0.0 2.1e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Smr domain Glyco_hydro_38N PF01074.22 CDL00717.1 - 0.024 14.0 0.0 0.032 13.6 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 N-terminal domain DUF1676 PF07898.13 CDL00717.1 - 0.36 10.9 1.1 0.48 10.4 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) MltA PF03562.17 CDL00718.1 - 2.3e-68 230.4 0.0 2.8e-68 230.1 0.0 1.1 1 0 0 1 1 1 1 MltA specific insert domain 3D PF06725.11 CDL00718.1 - 8.3e-22 77.2 0.0 2.1e-21 75.9 0.0 1.7 1 0 0 1 1 1 1 3D domain Tim44 PF04280.15 CDL00719.1 - 1.4e-48 164.8 0.0 1.7e-48 164.4 0.0 1.1 1 0 0 1 1 1 1 Tim44-like domain FxsA PF04186.13 CDL00720.1 - 1.2e-31 109.1 10.8 1.5e-31 108.7 10.8 1.1 1 0 0 1 1 1 1 FxsA cytoplasmic membrane protein Holin_9 PF16936.5 CDL00720.1 - 0.37 11.0 8.6 0.77 10.0 8.6 1.5 1 0 0 1 1 1 0 Putative holin Trp_oprn_chp PF09534.10 CDL00720.1 - 4.4 7.1 8.7 6.4 6.5 8.7 1.4 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SecB PF02556.14 CDL00721.1 - 2.9e-52 176.4 0.0 3.3e-52 176.1 0.0 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit SecB VWA_CoxE PF05762.14 CDL00722.1 - 6e-10 38.9 0.1 3e-09 36.6 0.0 2.0 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein AAA_5 PF07728.14 CDL00723.1 - 5.3e-12 45.9 0.0 1.4e-11 44.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CDL00723.1 - 2.5e-11 44.1 0.0 6.3e-11 42.8 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDL00723.1 - 3e-06 27.5 0.0 1.3e-05 25.5 0.0 2.0 1 1 1 2 2 2 1 AAA domain Sigma54_activat PF00158.26 CDL00723.1 - 4.7e-06 26.4 0.0 0.0062 16.3 0.0 2.1 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 CDL00723.1 - 5.1e-06 27.0 1.2 0.00048 20.5 0.7 3.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 CDL00723.1 - 8.4e-05 22.7 0.0 0.00012 22.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) NACHT PF05729.12 CDL00723.1 - 0.00069 19.6 0.1 0.0021 18.0 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_7 PF12775.7 CDL00723.1 - 0.0029 17.1 0.0 0.005 16.4 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 CDL00723.1 - 0.0035 16.6 0.3 0.01 15.1 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain DUF2075 PF09848.9 CDL00723.1 - 0.0042 16.4 0.0 0.005 16.1 0.0 1.3 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 CDL00723.1 - 0.0042 17.1 0.0 0.0075 16.3 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 CDL00723.1 - 0.0047 17.3 0.0 0.029 14.8 0.0 2.4 2 1 0 2 2 2 1 RNA helicase Sigma54_activ_2 PF14532.6 CDL00723.1 - 0.0082 16.3 0.0 0.063 13.4 0.0 2.3 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_30 PF13604.6 CDL00723.1 - 0.012 15.4 0.0 0.021 14.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 CDL00723.1 - 0.012 15.4 0.0 0.54 10.1 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 CDL00723.1 - 0.015 15.6 0.5 0.08 13.3 0.5 2.0 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDL00723.1 - 0.017 15.7 0.0 0.026 15.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CDL00723.1 - 0.024 14.4 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDL00723.1 - 0.032 13.6 0.0 0.056 12.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CDL00723.1 - 0.032 14.4 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDL00723.1 - 0.033 13.5 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_11 PF13086.6 CDL00723.1 - 0.12 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDL00723.1 - 0.15 11.7 0.0 0.36 10.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CDL00723.1 - 0.18 10.9 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain MCPsignal PF00015.21 CDL00724.1 - 6.2e-34 117.3 46.4 5.6e-32 110.9 26.5 3.5 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 CDL00724.1 - 0.00039 20.4 16.3 0.25 11.4 3.5 3.7 2 1 1 3 3 3 3 Protein of unknown function (DUF1664) LXG PF04740.12 CDL00724.1 - 0.0026 17.5 15.5 2.9 7.5 0.6 3.8 2 2 1 3 3 3 1 LXG domain of WXG superfamily Laminin_I PF06008.14 CDL00724.1 - 0.0045 16.7 25.3 1.2 8.8 1.9 3.7 1 1 2 3 3 3 3 Laminin Domain I DUF812 PF05667.11 CDL00724.1 - 0.0052 15.7 11.9 0.011 14.7 11.2 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF812) ISG65-75 PF11727.8 CDL00724.1 - 0.012 14.8 19.5 0.22 10.7 10.5 2.5 2 0 0 2 2 2 0 Invariant surface glycoprotein COG5 PF10392.9 CDL00724.1 - 0.017 15.3 3.9 0.2 11.8 0.3 3.2 1 1 0 2 2 2 0 Golgi transport complex subunit 5 Laminin_II PF06009.12 CDL00724.1 - 0.051 13.6 23.3 0.084 12.9 7.4 3.9 1 1 3 4 4 4 0 Laminin Domain II TMF_TATA_bd PF12325.8 CDL00724.1 - 0.092 13.0 4.3 0.85 9.9 1.6 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Hormone_1 PF00103.20 CDL00724.1 - 0.11 12.2 3.3 0.16 11.7 0.4 2.5 2 2 1 3 3 3 0 Somatotropin hormone family zf-C4H2 PF10146.9 CDL00724.1 - 0.16 12.3 7.1 6.5 7.0 3.6 2.4 1 1 0 2 2 2 0 Zinc finger-containing protein AAA_13 PF13166.6 CDL00724.1 - 0.17 10.5 15.3 4.3 5.9 14.0 2.0 1 1 1 2 2 2 0 AAA domain Tropomyosin_1 PF12718.7 CDL00724.1 - 0.19 11.9 4.3 0.2 11.8 2.6 1.9 2 0 0 2 2 2 0 Tropomyosin like DUF2130 PF09903.9 CDL00724.1 - 0.19 11.0 4.6 0.42 9.8 1.6 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2130) IFT57 PF10498.9 CDL00724.1 - 0.21 10.5 8.1 1.4 7.8 1.6 2.7 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 BioT2 PF15368.6 CDL00724.1 - 0.27 11.2 5.2 0.82 9.6 1.9 2.6 2 1 0 2 2 2 0 Spermatogenesis family BioT2 HisKA_3 PF07730.13 CDL00724.1 - 0.37 11.4 0.1 0.37 11.4 0.1 4.9 3 2 0 3 3 2 0 Histidine kinase BLOC1_2 PF10046.9 CDL00724.1 - 0.4 11.0 11.5 11 6.5 0.1 3.6 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ING PF12998.7 CDL00724.1 - 0.41 11.3 2.0 1.3 9.6 0.5 2.3 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Fib_alpha PF08702.10 CDL00724.1 - 0.41 10.8 10.5 4.9 7.3 0.2 3.1 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Dor1 PF04124.12 CDL00724.1 - 0.46 9.1 4.1 0.92 8.1 4.1 1.5 1 0 0 1 1 1 0 Dor1-like family PHA_synth_III_E PF09712.10 CDL00724.1 - 0.54 9.3 9.2 0.54 9.3 4.8 2.2 1 1 0 2 2 2 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) Mce4_CUP1 PF11887.8 CDL00724.1 - 0.57 9.6 15.4 0.37 10.2 7.7 2.5 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF2935 PF11155.8 CDL00724.1 - 0.65 10.3 2.7 34 4.8 2.7 3.0 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) DUF4559 PF15112.6 CDL00724.1 - 0.66 9.6 5.2 0.49 10.0 0.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) TMPIT PF07851.13 CDL00724.1 - 0.85 8.8 8.0 9.4 5.4 4.8 2.8 1 1 1 2 2 2 0 TMPIT-like protein COG2 PF06148.11 CDL00724.1 - 1.2 9.3 14.0 2.6 8.1 1.0 4.2 1 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF148 PF02520.17 CDL00724.1 - 1.3 9.2 17.5 3.2 7.9 0.4 3.5 2 2 0 3 3 3 0 Domain of unknown function DUF148 SlyX PF04102.12 CDL00724.1 - 1.3 9.7 10.3 0.49 11.0 1.3 3.6 3 1 1 4 4 3 0 SlyX Spc7 PF08317.11 CDL00724.1 - 1.3 7.8 10.1 2.6 6.9 5.2 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF3584 PF12128.8 CDL00724.1 - 1.5 6.3 20.4 0.13 9.8 0.8 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF3584) DUF3450 PF11932.8 CDL00724.1 - 1.5 8.0 22.6 0.53 9.5 1.4 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Nup88 PF10168.9 CDL00724.1 - 2.8 5.7 8.3 5.7 4.6 5.1 2.4 2 1 0 2 2 2 0 Nuclear pore component Sec8_exocyst PF04048.14 CDL00724.1 - 2.9 7.8 7.6 35 4.3 4.6 2.8 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain Peptidase_S64 PF08192.11 CDL00724.1 - 3.7 5.9 11.4 5.1 5.5 11.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF1690 PF07956.11 CDL00724.1 - 5.2 7.5 8.7 31 5.0 4.5 2.4 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) PIN_8 PF18476.1 CDL00724.1 - 6.2 6.6 10.8 10 5.9 5.2 2.8 1 1 1 2 2 2 0 PIN like domain DUF2203 PF09969.9 CDL00724.1 - 6.4 7.5 13.4 28 5.5 0.3 3.8 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) PAS_9 PF13426.7 CDL00725.1 - 2.1e-13 50.4 0.0 3.3e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 CDL00725.1 - 6.3e-13 48.8 0.1 1.2e-12 48.0 0.0 1.5 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 CDL00725.1 - 5.5e-10 39.3 0.0 8.8e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 CDL00725.1 - 9.6e-07 29.0 0.0 1.7e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDL00725.1 - 0.00026 20.9 0.0 0.00051 20.0 0.0 1.5 1 0 0 1 1 1 1 PAS domain DUF3235 PF11574.8 CDL00725.1 - 0.012 16.4 0.2 0.019 15.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) RsmJ PF04378.13 CDL00726.1 - 3e-91 305.0 0.0 3.6e-91 304.7 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA large subunit methyltransferase D, RlmJ His_Phos_1 PF00300.22 CDL00727.1 - 3.5e-41 141.0 0.0 3.9e-41 140.9 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CobS PF02654.15 CDL00728.1 - 5.3e-49 167.2 26.7 6.1e-49 167.0 26.7 1.0 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase DBI_PRT PF02277.17 CDL00729.1 - 1.1e-109 366.7 11.1 1.2e-109 366.5 11.1 1.0 1 0 0 1 1 1 1 Phosphoribosyltransferase Peptidase_M48 PF01435.18 CDL00730.1 - 1.5e-32 113.0 0.0 2.1e-32 112.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 PBP1_TM PF14812.6 CDL00730.1 - 0.2 12.0 5.6 0.41 11.1 5.6 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Thy1 PF02511.15 CDL00731.1 - 4.6e-52 176.6 0.1 5.7e-52 176.3 0.1 1.1 1 0 0 1 1 1 1 Thymidylate synthase complementing protein Polyketide_cyc PF03364.20 CDL00732.1 - 5.7e-18 65.4 0.0 7.3e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 CDL00732.1 - 0.00012 22.4 0.0 0.00015 22.1 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport cNMP_binding PF00027.29 CDL00733.1 - 1.4e-21 76.4 0.0 1.6e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF2786 PF10979.8 CDL00734.1 - 0.004 17.0 0.7 0.0088 15.9 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2786) DUF4139 PF13598.6 CDL00735.1 - 4.4e-14 52.7 0.0 9.9e-14 51.5 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4139) DUF11 PF01345.18 CDL00735.1 - 0.047 14.0 0.9 15 5.9 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function DUF11 RmuC PF02646.16 CDL00736.1 - 2.1e-61 207.6 0.5 3.6e-61 206.8 0.1 1.5 1 1 0 1 1 1 1 RmuC family UPF0242 PF06785.11 CDL00736.1 - 0.022 14.9 2.5 0.075 13.1 0.7 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SYCE1 PF15233.6 CDL00736.1 - 0.03 14.4 2.5 0.035 14.2 1.1 1.8 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 Baculo_PEP_C PF04513.12 CDL00736.1 - 0.037 14.1 8.1 0.027 14.5 2.1 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4201 PF13870.6 CDL00736.1 - 0.038 13.7 6.1 1.6 8.4 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) COG6 PF06419.11 CDL00736.1 - 0.09 11.0 3.3 0.095 10.9 0.4 1.9 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 PRP9_N PF16958.5 CDL00736.1 - 0.094 12.7 1.8 0.12 12.3 0.0 1.9 2 0 0 2 2 2 0 Pre-mRNA-splicing factor PRP9 N-terminus Exonuc_VII_L PF02601.15 CDL00736.1 - 0.095 12.3 7.9 0.028 14.0 4.4 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit Vps5 PF09325.10 CDL00736.1 - 0.19 11.2 4.0 1.6 8.2 0.0 2.5 2 1 0 2 2 2 0 Vps5 C terminal like BLOC1_2 PF10046.9 CDL00736.1 - 0.26 11.6 6.2 7.6 6.9 2.2 3.0 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4618 PF15397.6 CDL00736.1 - 0.3 10.5 7.1 0.5 9.7 3.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Leu_zip PF15294.6 CDL00736.1 - 0.52 9.8 8.1 1.2 8.6 0.2 2.2 2 0 0 2 2 2 0 Leucine zipper Virulence_fact PF13769.6 CDL00736.1 - 0.53 10.5 3.8 0.42 10.9 0.2 2.5 2 0 0 2 2 2 0 Virulence factor KxDL PF10241.9 CDL00736.1 - 0.66 10.3 12.9 6.9 7.0 0.2 3.5 2 1 2 4 4 4 0 Uncharacterized conserved protein DUF4446 PF14584.6 CDL00736.1 - 0.72 9.8 3.0 6.6 6.7 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) XhlA PF10779.9 CDL00736.1 - 0.82 9.9 3.9 2.5 8.3 0.5 2.7 2 0 0 2 2 2 0 Haemolysin XhlA DUF1664 PF07889.12 CDL00736.1 - 1.1 9.3 12.1 19 5.3 0.4 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4200 PF13863.6 CDL00736.1 - 1.9 8.9 10.9 1.1 9.7 4.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) HWE_HK PF07536.14 CDL00736.1 - 2.3 9.0 10.4 3.2 8.5 0.8 3.3 1 1 2 3 3 3 0 HWE histidine kinase Fib_alpha PF08702.10 CDL00736.1 - 5 7.3 6.4 24 5.1 2.2 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Rx_N PF18052.1 CDL00736.1 - 7.9 6.8 9.7 2.2 8.6 0.3 2.9 2 1 0 2 2 2 0 Rx N-terminal domain NPV_P10 PF05531.12 CDL00736.1 - 9.4 6.8 15.9 2.8 8.5 1.2 3.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein CorA PF01544.18 CDL00737.1 - 0.33 10.2 0.0 0.33 10.2 0.0 3.8 2 1 3 5 5 5 0 CorA-like Mg2+ transporter protein Arginosuc_synth PF00764.19 CDL00738.1 - 1.1e-154 515.4 0.0 1.3e-154 515.2 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 CDL00738.1 - 0.0013 18.2 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 CDL00738.1 - 0.0023 17.6 0.0 0.0037 17.0 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase PepSY_2 PF13670.6 CDL00739.1 - 5.1e-15 55.3 1.2 1.5e-06 28.1 0.1 2.0 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain PepSY PF03413.19 CDL00739.1 - 0.037 14.6 0.4 5.6 7.6 0.1 2.4 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain CBM_48 PF02922.18 CDL00739.1 - 0.056 13.8 0.4 0.6 10.5 0.0 2.2 2 1 1 3 3 3 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) E1-E2_ATPase PF00122.20 CDL00741.1 - 1.3e-54 184.5 0.2 1.3e-54 184.5 0.2 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDL00741.1 - 1.9e-46 158.1 2.4 4.5e-46 156.9 2.4 1.7 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CDL00741.1 - 3.7e-18 66.6 11.3 5.8e-17 62.7 11.3 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDL00741.1 - 4e-17 62.1 0.0 7.6e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CDL00741.1 - 9.5e-17 60.5 0.0 1.8e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.7 CDL00741.1 - 2.1e-05 25.0 4.5 0.00023 21.6 3.5 2.8 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDL00741.1 - 0.00067 19.5 1.4 0.002 17.9 1.1 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase NiFe_hyd_3_EhaA PF17367.2 CDL00741.1 - 0.044 13.9 2.0 0.16 12.2 2.0 1.9 1 0 0 1 1 1 0 NiFe-hydrogenase-type-3 Eha complex subunit A PT-VENN PF04829.13 CDL00741.1 - 1.2 9.3 3.6 1 9.5 0.4 2.7 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif Response_reg PF00072.24 CDL00742.1 - 1.9e-19 69.9 0.0 2.9e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain GerE PF00196.19 CDL00742.1 - 2.6e-18 65.3 0.3 4.2e-18 64.6 0.3 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDL00742.1 - 1.3e-09 37.6 0.2 2.5e-09 36.6 0.2 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 CDL00742.1 - 1.9e-05 24.1 0.2 4.2e-05 23.0 0.2 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_40 PF14493.6 CDL00742.1 - 0.0017 18.7 0.1 0.0035 17.8 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 CDL00742.1 - 0.0092 15.7 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_20 PF12840.7 CDL00742.1 - 0.015 15.3 0.1 0.12 12.5 0.0 2.4 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_AsnC-type PF13404.6 CDL00742.1 - 0.03 14.1 0.1 3.3 7.6 0.0 2.6 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 CDL00742.1 - 0.045 13.3 0.1 0.31 10.6 0.0 2.3 1 1 1 2 2 2 0 Winged helix-turn-helix DNA-binding OKR_DC_1_N PF03709.15 CDL00742.1 - 0.083 13.2 0.0 0.43 10.9 0.0 2.0 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain Gp_dh_C PF02800.20 CDL00743.1 - 2.5e-65 218.9 0.0 3.6e-65 218.4 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CDL00743.1 - 7e-38 129.0 0.0 1.3e-37 128.2 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 CDL00743.1 - 0.0058 16.8 0.2 0.062 13.4 0.2 2.5 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_3 PF03447.16 CDL00743.1 - 0.051 14.2 0.1 0.27 11.9 0.1 2.0 1 1 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 CDL00743.1 - 0.07 14.0 0.0 0.32 11.8 0.0 2.0 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold 2-Hacid_dh_C PF02826.19 CDL00743.1 - 0.13 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PGK PF00162.19 CDL00744.1 - 1.1e-149 498.5 0.6 1.3e-149 498.3 0.6 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Mur_ligase_C PF02875.21 CDL00744.1 - 0.024 14.9 0.1 20 5.5 0.0 3.3 3 0 0 3 3 3 0 Mur ligase family, glutamate ligase domain DUF2514 PF10721.9 CDL00744.1 - 0.043 13.9 0.2 0.043 13.9 0.2 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2514) GHMP_kinases_C PF08544.13 CDL00744.1 - 0.24 11.8 1.7 0.49 10.8 0.4 2.2 2 0 0 2 2 2 0 GHMP kinases C terminal Fer2 PF00111.27 CDL00746.1 - 8.3e-16 57.7 0.3 1.7e-15 56.7 0.3 1.6 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NAD_binding_1 PF00175.21 CDL00746.1 - 4.1e-10 40.3 0.0 7.2e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CDL00746.1 - 4.8e-10 39.7 0.0 8.2e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Fer2_4 PF13510.6 CDL00746.1 - 5.4e-05 23.2 0.2 0.0017 18.4 0.0 2.7 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain AurF PF11583.8 CDL00747.1 - 1.5e-05 24.5 0.0 4.3e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 P-aminobenzoate N-oxygenase AurF Ribonuc_red_sm PF00268.21 CDL00747.1 - 6.7e-05 22.5 0.0 9e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Rubrerythrin PF02915.17 CDL00747.1 - 0.0013 19.1 0.0 1.7 9.0 0.0 2.3 2 0 0 2 2 2 2 Rubrerythrin ABC_tran PF00005.27 CDL00748.1 - 1.7e-31 109.6 0.0 2.5e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDL00748.1 - 2.4e-15 57.1 0.7 3.6e-07 30.3 0.1 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDL00748.1 - 0.00015 22.4 0.0 0.00022 21.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDL00748.1 - 0.00041 19.9 0.4 0.026 13.9 0.4 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDL00748.1 - 0.00085 19.0 0.1 0.0021 17.8 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CDL00748.1 - 0.0022 18.1 0.0 0.0025 17.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_30 PF13604.6 CDL00748.1 - 0.0028 17.4 0.2 0.025 14.3 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CDL00748.1 - 0.0031 17.3 0.0 0.0042 16.8 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 CDL00748.1 - 0.0042 17.4 0.2 0.0088 16.3 0.2 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDL00748.1 - 0.0053 17.2 0.3 0.0081 16.6 0.3 1.5 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CDL00748.1 - 0.0057 16.6 0.1 0.0094 15.9 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase DUF3584 PF12128.8 CDL00748.1 - 0.0069 14.0 0.1 0.0086 13.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_22 PF13401.6 CDL00748.1 - 0.0095 16.2 0.2 0.054 13.8 0.2 2.0 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.22 CDL00748.1 - 0.016 14.8 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_27 PF13514.6 CDL00748.1 - 0.019 14.6 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDL00748.1 - 0.019 14.5 0.9 0.076 12.6 0.3 2.1 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDL00748.1 - 0.023 14.9 0.1 0.034 14.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 CDL00748.1 - 0.028 13.2 0.2 0.18 10.5 0.2 1.9 2 0 0 2 2 2 0 Predicted ATPase of the ABC class TsaE PF02367.17 CDL00748.1 - 0.041 13.9 0.1 0.069 13.1 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CDL00748.1 - 0.042 13.8 0.1 0.075 12.9 0.1 1.4 1 0 0 1 1 1 0 NACHT domain Zeta_toxin PF06414.12 CDL00748.1 - 0.045 13.0 0.1 0.071 12.4 0.1 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_13 PF13166.6 CDL00748.1 - 0.087 11.5 0.0 0.11 11.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CDL00748.1 - 0.13 11.7 0.1 0.23 10.8 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 CDL00748.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) BCA_ABC_TP_C PF12399.8 CDL00748.1 - 0.13 12.2 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 Branched-chain amino acid ATP-binding cassette transporter AAA_18 PF13238.6 CDL00748.1 - 0.15 12.6 0.0 0.28 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 CDL00748.1 - 0.16 11.7 0.1 0.29 10.9 0.1 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF2813 PF11398.8 CDL00748.1 - 0.19 11.0 0.0 0.4 9.9 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) IL5 PF02025.15 CDL00748.1 - 0.19 12.0 0.0 1.7 8.9 0.0 2.1 2 0 0 2 2 2 0 Interleukin 5 cobW PF02492.19 CDL00748.1 - 0.2 11.2 0.2 0.34 10.5 0.2 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 CDL00749.1 - 2.3e-30 105.9 0.0 3e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter BCA_ABC_TP_C PF12399.8 CDL00749.1 - 1.5e-12 47.1 0.2 2.6e-12 46.4 0.2 1.4 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_21 PF13304.6 CDL00749.1 - 3.3e-06 27.1 0.4 0.0012 18.7 0.1 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDL00749.1 - 1.7e-05 24.5 0.1 3.5e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDL00749.1 - 4.3e-05 24.1 0.2 6.1e-05 23.6 0.2 1.2 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDL00749.1 - 0.00032 20.5 1.0 0.0048 16.6 1.0 2.1 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDL00749.1 - 0.00078 18.9 0.5 0.088 12.2 0.1 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CDL00749.1 - 0.0035 17.4 0.1 0.02 15.0 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDL00749.1 - 0.0058 16.5 0.2 0.02 14.8 0.1 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_27 PF13514.6 CDL00749.1 - 0.0065 16.1 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain KdpD PF02702.17 CDL00749.1 - 0.023 14.1 0.1 0.04 13.4 0.0 1.4 1 1 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain AAA_22 PF13401.6 CDL00749.1 - 0.027 14.8 0.4 0.89 9.8 0.0 2.6 2 1 1 3 3 3 0 AAA domain DAHP_snth_FXD PF18152.1 CDL00749.1 - 0.085 12.7 2.0 0.45 10.4 0.3 2.6 3 0 0 3 3 3 0 DAHP synthase ferredoxin-like domain AAA_15 PF13175.6 CDL00749.1 - 0.095 12.4 0.0 0.19 11.4 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.6 CDL00749.1 - 0.11 12.1 0.2 5.3 6.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CDL00749.1 - 0.12 11.7 0.1 0.21 11.0 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF2316 PF10078.9 CDL00749.1 - 0.15 12.3 0.0 0.46 10.8 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) AAA_13 PF13166.6 CDL00749.1 - 0.17 10.5 0.0 0.22 10.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 CDL00749.1 - 1.8 7.3 4.8 3.6 6.3 0.2 2.6 2 1 0 2 2 2 0 Predicted ATPase of the ABC class BPD_transp_2 PF02653.16 CDL00750.1 - 5.1e-38 130.8 38.3 7.8e-38 130.2 38.3 1.2 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component ATP19 PF11022.8 CDL00750.1 - 0.11 12.9 0.1 0.44 10.9 0.1 2.1 1 0 0 1 1 1 0 ATP synthase subunit K DUF5353 PF17304.2 CDL00750.1 - 1.3 8.9 6.8 6.4 6.6 6.7 2.4 1 1 0 1 1 1 0 Family of unknown function (DUF5353) BPD_transp_2 PF02653.16 CDL00751.1 - 3e-33 115.1 49.2 3.5e-33 114.9 49.2 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component Peripla_BP_6 PF13458.6 CDL00752.1 - 1.7e-66 225.2 5.0 2e-66 225.0 5.0 1.0 1 0 0 1 1 1 1 Periplasmic binding protein Peripla_BP_5 PF13433.6 CDL00752.1 - 1.6e-19 70.2 0.1 4.1e-13 49.0 0.0 2.1 2 0 0 2 2 2 2 Periplasmic binding protein domain ANF_receptor PF01094.28 CDL00752.1 - 9.9e-17 61.1 0.0 1.2e-16 60.7 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region ABC_sub_bind PF04392.12 CDL00752.1 - 0.062 12.5 0.0 0.18 11.0 0.0 1.7 1 0 0 1 1 1 0 ABC transporter substrate binding protein Ribosomal_S11 PF00411.19 CDL00752.1 - 0.12 12.8 0.2 0.37 11.2 0.0 1.9 2 0 0 2 2 2 0 Ribosomal protein S11 IPT PF01745.16 CDL00752.1 - 0.14 11.6 0.1 0.24 10.7 0.1 1.4 1 0 0 1 1 1 0 Isopentenyl transferase PaaX_C PF08223.11 CDL00753.1 - 2.5e-32 111.1 0.3 5.7e-32 109.9 0.1 1.7 2 0 0 2 2 2 1 PaaX-like protein C-terminal domain PaaX PF07848.12 CDL00753.1 - 4.2e-28 97.4 0.1 9e-28 96.3 0.1 1.6 1 0 0 1 1 1 1 PaaX-like protein PadR PF03551.14 CDL00753.1 - 0.01 15.8 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family bMG6 PF17962.1 CDL00754.1 - 8.1e-29 100.1 2.8 1.2e-28 99.5 1.6 2.1 2 0 0 2 2 2 1 Bacterial macroglobulin domain 6 bMG3 PF11974.8 CDL00754.1 - 1.6e-26 92.3 0.0 1.1e-25 89.7 0.0 2.5 2 0 0 2 2 2 1 Bacterial alpha-2-macroglobulin MG3 domain bMG5 PF17972.1 CDL00754.1 - 1.4e-21 77.1 0.0 6.1e-21 75.1 0.0 2.2 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG5 domain MG2 PF01835.19 CDL00754.1 - 1.2e-20 73.7 0.0 1.3e-18 67.2 0.0 4.1 4 1 0 4 4 4 1 MG2 domain A2M_BRD PF07703.14 CDL00754.1 - 2e-17 63.9 0.0 1.2e-15 58.1 0.0 3.0 2 0 0 2 2 2 1 Alpha-2-macroglobulin bait region domain bMG10 PF17973.1 CDL00754.1 - 1.6e-13 51.0 0.1 6.5e-07 29.6 0.0 2.8 2 0 0 2 2 2 2 Bacterial Alpha-2-macroglobulin MG10 domain A2M PF00207.22 CDL00754.1 - 5.2e-09 35.8 0.0 2.1e-08 33.9 0.0 2.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin family TED_complement PF07678.14 CDL00754.1 - 5.4e-07 28.9 0.0 8.3e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 A-macroglobulin TED domain Transgly PF00912.22 CDL00755.1 - 1.9e-38 131.7 0.0 3.1e-38 131.0 0.0 1.3 1 0 0 1 1 1 1 Transglycosylase BiPBP_C PF06832.12 CDL00755.1 - 1e-12 47.9 0.2 3.3e-12 46.3 0.2 1.9 1 0 0 1 1 1 1 Penicillin-Binding Protein C-terminus Family Transpeptidase PF00905.22 CDL00755.1 - 2.3e-11 43.4 0.0 1.4e-10 40.9 0.0 1.9 1 1 0 1 1 1 1 Penicillin binding protein transpeptidase domain Glyco_trans_4_4 PF13579.6 CDL00756.1 - 8.5e-19 68.6 2.3 8.5e-19 68.6 2.3 2.1 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CDL00756.1 - 1e-17 64.6 0.3 1.8e-17 63.8 0.3 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 CDL00756.1 - 3e-16 59.4 0.0 5.1e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDL00756.1 - 1.2e-14 54.9 0.2 3.3e-14 53.4 0.1 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDL00756.1 - 0.0012 19.2 0.1 0.0039 17.6 0.1 1.9 1 0 0 1 1 1 1 Glycosyl transferases group 1 Polysacc_synt_2 PF02719.15 CDL00757.1 - 2.7e-110 368.1 0.0 3.4e-110 367.8 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CDL00757.1 - 1.6e-20 73.6 0.0 1.1e-19 70.9 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDL00757.1 - 1.1e-18 67.4 0.0 1.9e-17 63.3 0.0 2.2 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CDL00757.1 - 8.2e-12 45.2 0.0 1.3e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CDL00757.1 - 2.7e-11 43.0 0.0 4.5e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family CoA_binding_3 PF13727.6 CDL00757.1 - 1.3e-09 38.3 0.3 2.8e-09 37.2 0.3 1.5 1 0 0 1 1 1 1 CoA-binding domain adh_short PF00106.25 CDL00757.1 - 0.0051 16.3 0.0 0.026 14.0 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 CDL00757.1 - 0.018 14.9 1.4 0.07 13.0 1.3 2.1 1 1 0 1 1 1 0 NAD(P)H-binding ThiF PF00899.21 CDL00757.1 - 0.076 12.4 0.1 0.16 11.3 0.1 1.5 1 0 0 1 1 1 0 ThiF family NAD_binding_4 PF07993.12 CDL00757.1 - 0.11 11.7 0.2 0.49 9.5 0.0 2.0 2 0 0 2 2 2 0 Male sterility protein Hepar_II_III_N PF16889.5 CDL00758.1 - 1.4e-24 87.0 0.1 2e-24 86.5 0.1 1.1 1 0 0 1 1 1 1 Heparinase II/III N-terminus Hepar_II_III PF07940.13 CDL00758.1 - 6.3e-16 58.7 0.3 1.1e-15 57.9 0.3 1.3 1 0 0 1 1 1 1 Heparinase II/III-like protein B12-binding PF02310.19 CDL00759.1 - 2.8e-13 49.9 0.0 1.3e-12 47.8 0.0 2.1 2 0 0 2 2 2 1 B12 binding domain Radical_SAM PF04055.21 CDL00759.1 - 1.4e-09 38.5 0.0 5.1e-09 36.7 0.0 1.8 2 0 0 2 2 2 1 Radical SAM superfamily Methyltransf_11 PF08241.12 CDL00760.1 - 5.9e-17 62.1 0.0 9e-17 61.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL00760.1 - 9.1e-15 55.2 0.0 1.5e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL00760.1 - 6.1e-14 52.2 0.2 2.1e-13 50.5 0.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00760.1 - 4.9e-11 42.6 0.0 8.4e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00760.1 - 5.3e-10 39.9 0.0 9.8e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CDL00760.1 - 2.4e-07 30.0 0.0 3.6e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Trm112p PF03966.16 CDL00760.1 - 1e-05 26.0 0.3 2.7e-05 24.6 0.3 1.8 1 1 0 1 1 1 1 Trm112p-like protein CMAS PF02353.20 CDL00760.1 - 0.0016 17.8 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CDL00760.1 - 0.0021 17.4 0.0 0.0034 16.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Zn_Tnp_IS1595 PF12760.7 CDL00760.1 - 0.018 15.0 0.1 0.061 13.3 0.1 2.0 1 1 0 1 1 1 0 Transposase zinc-ribbon domain FtsJ PF01728.19 CDL00760.1 - 0.021 14.9 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Terminase_GpA PF05876.12 CDL00760.1 - 0.046 12.3 0.1 0.065 11.8 0.1 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) MTS PF05175.14 CDL00760.1 - 0.11 12.1 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Lar_restr_allev PF14354.6 CDL00760.1 - 0.12 12.8 2.3 0.22 11.9 0.5 2.3 2 1 0 2 2 2 0 Restriction alleviation protein Lar Methyltransf_15 PF09445.10 CDL00760.1 - 0.13 11.9 0.0 0.66 9.5 0.0 1.9 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase PhnA_Zn_Ribbon PF08274.12 CDL00760.1 - 4.1 7.5 5.7 4 7.5 0.3 2.6 3 0 0 3 3 2 0 PhnA Zinc-Ribbon Hydrolase_like PF13242.6 CDL00761.1 - 6.5e-13 48.5 0.2 1e-12 47.9 0.2 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 CDL00761.1 - 6.4e-08 32.9 0.0 0.0004 20.5 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PNK3P PF08645.11 CDL00761.1 - 1.2e-06 28.3 0.0 1.4e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase Hydrolase_6 PF13344.6 CDL00761.1 - 0.00079 19.5 0.0 0.0019 18.3 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDL00761.1 - 0.0016 18.8 0.1 0.0033 17.8 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDL00761.1 - 0.0069 16.8 0.0 0.0095 16.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HHH PF00633.23 CDL00761.1 - 0.023 14.5 0.0 0.058 13.3 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif DnaJ PF00226.31 CDL00762.1 - 4.2e-05 23.6 0.0 8.8e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain EAL PF00563.20 CDL00763.1 - 4.6e-73 245.6 0.0 7.8e-73 244.9 0.0 1.4 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDL00763.1 - 3.3e-40 137.5 0.0 5.7e-40 136.7 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_3 PF08447.12 CDL00763.1 - 1.2e-21 76.8 0.0 1.5e-10 41.2 0.0 3.2 3 0 0 3 3 3 2 PAS fold PAS_9 PF13426.7 CDL00763.1 - 3.5e-18 65.7 0.0 9.2e-11 41.9 0.0 3.6 3 0 0 3 3 3 3 PAS domain PAS_4 PF08448.10 CDL00763.1 - 2.2e-13 50.4 1.3 1.9e-06 28.1 0.0 3.6 3 0 0 3 3 3 2 PAS fold PAS PF00989.25 CDL00763.1 - 3.1e-11 43.3 0.0 3.7e-09 36.6 0.0 3.2 3 0 0 3 3 3 1 PAS fold PAS_8 PF13188.7 CDL00763.1 - 3.4e-08 33.3 0.5 9.9e-05 22.3 0.2 2.8 2 0 0 2 2 2 2 PAS domain GDP_Man_Dehyd PF16363.5 CDL00764.1 - 2.7e-54 184.8 0.0 1.8e-53 182.1 0.0 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDL00764.1 - 9.1e-49 166.1 0.0 1.1e-48 165.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CDL00764.1 - 7.2e-11 41.7 0.0 1.4e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 CDL00764.1 - 4.2e-07 29.4 0.0 0.032 13.4 0.0 3.0 3 0 0 3 3 3 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDL00764.1 - 3.2e-06 26.5 0.0 8.2e-06 25.1 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CDL00764.1 - 8.6e-06 25.0 0.0 1.7e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 CDL00764.1 - 0.012 15.1 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase KR PF08659.10 CDL00764.1 - 0.22 11.4 0.0 0.45 10.4 0.0 1.4 1 0 0 1 1 1 0 KR domain SRP54 PF00448.22 CDL00765.1 - 4.2e-71 238.6 0.2 7.8e-71 237.8 0.2 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 CDL00765.1 - 4.6e-32 110.6 2.2 4.6e-32 110.6 2.2 1.9 2 0 0 2 2 2 1 Signal peptide binding domain SRP54_N PF02881.19 CDL00765.1 - 5.4e-21 74.6 2.6 9.9e-21 73.8 0.4 2.5 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 CDL00765.1 - 1.2e-07 31.9 0.2 1.2e-07 31.9 0.2 2.3 3 0 0 3 3 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain Zeta_toxin PF06414.12 CDL00765.1 - 3.4e-06 26.5 0.0 8.8e-06 25.1 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_31 PF13614.6 CDL00765.1 - 1.8e-05 24.7 0.7 0.0006 19.8 0.3 2.6 1 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CDL00765.1 - 0.00027 21.1 0.0 0.00071 19.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 CDL00765.1 - 0.00061 19.1 8.5 0.0012 18.1 0.6 3.3 2 2 1 3 3 3 1 Anion-transporting ATPase ParA PF10609.9 CDL00765.1 - 0.0057 16.1 0.2 0.014 14.9 0.1 1.7 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase APS_kinase PF01583.20 CDL00765.1 - 0.0095 15.8 0.1 0.038 13.9 0.0 2.0 2 0 0 2 2 2 1 Adenylylsulphate kinase TM1506 PF08973.10 CDL00765.1 - 0.04 13.6 2.0 0.18 11.5 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1893) KTI12 PF08433.10 CDL00765.1 - 0.042 13.3 0.0 0.091 12.2 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 6PF2K PF01591.18 CDL00765.1 - 0.062 12.6 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase VirC1 PF07015.11 CDL00765.1 - 0.064 12.5 0.0 0.16 11.2 0.0 1.7 1 0 0 1 1 1 0 VirC1 protein GTP_EFTU PF00009.27 CDL00765.1 - 0.086 12.4 0.7 0.33 10.5 0.1 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CDL00765.1 - 0.091 12.2 0.1 4.8 6.6 0.0 2.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 CDL00765.1 - 0.15 11.5 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF4175 PF13779.6 CDL00765.1 - 0.44 8.4 5.4 0.15 9.9 2.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4175) Ribosomal_S16 PF00886.19 CDL00766.1 - 3.8e-26 90.9 0.0 6.1e-26 90.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 RimM PF01782.18 CDL00767.1 - 2.9e-23 81.9 0.1 5.1e-23 81.1 0.1 1.4 1 0 0 1 1 1 1 RimM N-terminal domain PRC PF05239.16 CDL00767.1 - 2e-09 37.4 0.2 3.7e-09 36.5 0.2 1.4 1 0 0 1 1 1 1 PRC-barrel domain tRNA_m1G_MT PF01746.21 CDL00768.1 - 2.8e-53 180.5 0.0 3.2e-53 180.3 0.0 1.0 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Ribosomal_L19 PF01245.20 CDL00769.1 - 1.3e-49 166.7 2.4 1.7e-49 166.4 2.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L19 K_channel_TID PF07941.11 CDL00769.1 - 7.9 7.0 13.7 14 6.2 13.7 1.4 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Aconitase PF00330.20 CDL00770.1 - 9.2e-161 535.9 0.8 1e-160 535.7 0.8 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CDL00771.1 - 1.1e-37 129.3 0.0 1.4e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Aconitase C-terminal domain Chitin_synth_1N PF08407.11 CDL00771.1 - 0.022 14.7 0.0 0.076 13.0 0.0 1.8 2 0 0 2 2 2 0 Chitin synthase N-terminal Iso_dh PF00180.20 CDL00772.1 - 1.5e-131 438.7 0.0 1.7e-131 438.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase GTP_cyclohydroI PF01227.22 CDL00773.1 - 9.4e-76 253.2 0.0 1.1e-75 253.0 0.0 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 CDL00773.1 - 0.00017 21.7 0.0 0.00028 21.0 0.0 1.4 1 0 0 1 1 1 1 QueF-like protein EIF_2_alpha PF07541.12 CDL00773.1 - 0.046 13.8 0.1 0.066 13.3 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit DUF525 PF04379.14 CDL00774.1 - 1.7e-37 127.5 0.1 2e-37 127.3 0.1 1.1 1 0 0 1 1 1 1 ApaG domain DUF4354 PF14263.6 CDL00774.1 - 0.012 15.4 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4354) Cys_Met_Meta_PP PF01053.20 CDL00775.1 - 3.6e-129 430.6 0.0 4.1e-129 430.5 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CDL00775.1 - 9.4e-09 34.9 0.0 1.3e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CDL00775.1 - 3.7e-08 33.1 0.7 7.2e-08 32.1 0.3 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CDL00775.1 - 5.2e-06 25.7 0.0 9.8e-06 24.8 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V GDC-P PF02347.16 CDL00775.1 - 0.001 18.0 0.0 0.0015 17.5 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein Met_gamma_lyase PF06838.11 CDL00775.1 - 0.059 11.9 0.0 0.13 10.8 0.0 1.5 2 0 0 2 2 2 0 Methionine gamma-lyase adh_short_C2 PF13561.6 CDL00776.1 - 5.4e-82 274.8 0.0 6.2e-82 274.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDL00776.1 - 2.2e-20 73.0 0.0 2.8e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Enoyl_reductase PF12241.8 CDL00776.1 - 0.061 12.7 0.0 0.22 10.9 0.0 1.7 2 0 0 2 2 2 0 Trans-2-enoyl-CoA reductase catalytic region SBP_bac_3 PF00497.20 CDL00777.1 - 3.5e-07 29.9 0.0 1.1e-06 28.3 0.0 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF2336 PF10098.9 CDL00778.1 - 6.2e-59 199.6 36.0 4.9e-56 190.1 17.8 2.0 2 0 0 2 2 2 2 Uncharacterised protein conserved in bacteria (DUF2336) HEAT PF02985.22 CDL00778.1 - 0.0029 17.7 4.8 5 7.7 0.1 5.3 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 CDL00778.1 - 0.041 13.9 0.5 0.44 10.6 0.1 2.7 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 GGDEF PF00990.21 CDL00779.1 - 7e-40 136.4 0.0 1.3e-39 135.6 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_4 PF08448.10 CDL00779.1 - 4.9e-10 39.6 0.1 5e-08 33.2 0.0 3.2 2 1 1 3 3 3 1 PAS fold PAS_9 PF13426.7 CDL00779.1 - 7.8e-09 35.7 0.0 2.3e-08 34.2 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CDL00779.1 - 2.2e-05 24.4 0.0 0.00013 22.0 0.0 2.2 2 0 0 2 2 2 1 PAS fold GAF_3 PF13492.6 CDL00779.1 - 0.0024 18.2 0.0 0.27 11.6 0.0 2.6 1 1 0 1 1 1 1 GAF domain HAD_2 PF13419.6 CDL00780.1 - 7.5e-11 42.4 0.0 1.8e-10 41.2 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDL00780.1 - 6.1e-09 36.5 0.0 4.2e-07 30.5 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDL00780.1 - 0.00028 20.9 0.1 0.00057 19.9 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CDL00780.1 - 0.00029 21.3 0.9 0.00049 20.6 0.5 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NIF PF03031.18 CDL00780.1 - 0.04 13.7 0.0 2.8 7.7 0.0 2.4 2 1 0 2 2 2 0 NLI interacting factor-like phosphatase THDPS_N_2 PF14805.6 CDL00781.1 - 1.2e-24 86.3 1.4 1.9e-24 85.6 1.4 1.3 1 0 0 1 1 1 1 Tetrahydrodipicolinate N-succinyltransferase N-terminal Hexapep PF00132.24 CDL00781.1 - 1.3e-12 46.9 6.8 3.6e-05 23.3 0.2 3.4 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDL00781.1 - 8.5e-11 41.4 0.5 8.5e-11 41.4 0.5 3.4 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase Peptidase_M20 PF01546.28 CDL00782.1 - 3.2e-42 144.6 0.0 5.5e-42 143.8 0.0 1.4 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDL00782.1 - 3.1e-21 75.3 0.0 5.9e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Methyltransf_3 PF01596.17 CDL00784.1 - 6.1e-37 126.9 0.0 7.7e-37 126.5 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CDL00784.1 - 6e-19 69.0 0.0 1.1e-18 68.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDL00784.1 - 0.00035 20.4 0.0 0.00056 19.7 0.0 1.3 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CDL00784.1 - 0.011 15.6 0.0 0.016 15.0 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain T2SSF PF00482.23 CDL00785.1 - 0.14 12.1 0.7 11 6.0 0.0 2.8 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Peptidase_M24 PF00557.24 CDL00787.1 - 1.5e-52 178.3 0.0 1.7e-52 178.1 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 SfsA PF03749.13 CDL00788.1 - 2.4e-50 170.0 0.0 3.1e-50 169.7 0.0 1.1 1 0 0 1 1 1 1 Sugar fermentation stimulation protein RE domain SfsA_N PF17746.1 CDL00788.1 - 1.2e-22 79.9 0.0 2.4e-22 78.9 0.0 1.6 1 0 0 1 1 1 1 SfsA N-terminal OB domain Methyltransf_11 PF08241.12 CDL00789.1 - 1.8e-20 73.4 0.0 3.3e-20 72.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL00789.1 - 1.8e-15 57.4 0.0 3.6e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL00789.1 - 5.7e-15 55.5 0.0 9.7e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00789.1 - 6.7e-12 46.0 0.0 1.6e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00789.1 - 2.5e-07 30.6 0.0 4.8e-07 29.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDL00789.1 - 4.7e-07 29.4 0.0 9.2e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 CDL00789.1 - 8.6e-05 22.5 0.0 0.00014 21.8 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.16 CDL00789.1 - 0.1 11.1 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_7 PF03492.15 CDL00789.1 - 0.18 11.0 0.1 0.36 10.0 0.0 1.5 2 0 0 2 2 2 0 SAM dependent carboxyl methyltransferase Pribosyltran PF00156.27 CDL00790.1 - 2.1e-07 30.6 0.0 4.4e-07 29.5 0.0 1.5 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CDL00790.1 - 0.096 12.1 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Rad50_zn_hook PF04423.14 CDL00790.1 - 0.17 11.8 1.7 0.36 10.7 1.7 1.5 1 0 0 1 1 1 0 Rad50 zinc hook motif DZR PF12773.7 CDL00790.1 - 0.8 9.8 9.5 8.6 6.5 8.9 2.4 1 1 2 3 3 3 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 CDL00790.1 - 1 9.3 8.2 1.2 9.0 5.0 2.7 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zinc-ribbons_6 PF07191.12 CDL00790.1 - 1.6 8.8 5.5 3.2 7.8 5.5 1.5 1 0 0 1 1 1 0 zinc-ribbons zf-NADH-PPase PF09297.11 CDL00790.1 - 7.5 6.3 9.7 0.32 10.7 2.4 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain TF_Zn_Ribbon PF08271.12 CDL00790.1 - 9.5 5.8 9.3 0.11 12.0 1.5 1.9 2 0 0 2 2 2 0 TFIIB zinc-binding Glutaredoxin PF00462.24 CDL00791.1 - 1.2e-24 86.2 0.0 1.5e-24 86.0 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 CDL00791.1 - 5e-05 23.6 0.0 5.9e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 CDL00791.1 - 0.00084 19.7 0.0 0.0011 19.4 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) SH3BGR PF04908.15 CDL00791.1 - 0.0024 18.0 0.0 0.0032 17.6 0.0 1.2 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Thioredoxin_3 PF13192.6 CDL00791.1 - 0.0048 16.9 0.0 0.013 15.6 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin domain Thioredoxin_4 PF13462.6 CDL00791.1 - 0.021 15.0 0.2 4.6 7.4 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin GST_N_2 PF13409.6 CDL00791.1 - 0.036 14.4 0.0 0.044 14.1 0.0 1.1 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DUF1223 PF06764.11 CDL00791.1 - 0.06 13.4 0.0 0.25 11.4 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1223) CN_hydrolase PF00795.22 CDL00792.1 - 4.8e-47 160.5 0.2 5.4e-47 160.3 0.2 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Methyltransf_23 PF13489.6 CDL00793.1 - 0.00037 20.4 0.0 0.0017 18.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL00793.1 - 0.0082 16.8 0.0 0.017 15.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL00793.1 - 0.016 15.8 0.1 0.043 14.5 0.1 1.8 1 1 0 1 1 1 0 Methyltransferase domain NAD_binding_10 PF13460.6 CDL00793.1 - 0.054 13.4 0.0 0.086 12.7 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding TehB PF03848.14 CDL00793.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.1 1 0 0 1 1 1 0 Tellurite resistance protein TehB DUF1178 PF06676.11 CDL00794.1 - 1.6e-50 171.4 1.3 8.5e-50 169.0 1.3 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1178) Zn-ribbon_8 PF09723.10 CDL00794.1 - 0.017 15.3 0.1 0.04 14.0 0.1 1.7 1 1 0 1 1 1 0 Zinc ribbon domain YdjO PF14169.6 CDL00794.1 - 0.034 13.9 0.2 0.069 12.9 0.2 1.6 1 0 0 1 1 1 0 Cold-inducible protein YdjO ABC_membrane PF00664.23 CDL00795.1 - 8.9e-34 117.4 6.7 1.1e-33 117.1 6.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDL00795.1 - 9e-33 113.7 0.0 2.1e-32 112.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDL00795.1 - 2.3e-08 33.7 0.2 3.9e-06 26.5 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDL00795.1 - 0.0021 18.5 0.5 0.0071 16.7 0.5 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDL00795.1 - 0.0073 16.6 0.1 0.048 13.9 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CDL00795.1 - 0.02 14.6 0.1 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 CDL00795.1 - 0.022 14.6 0.4 0.13 12.1 0.1 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 CDL00795.1 - 0.043 13.1 0.1 0.11 11.7 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin Cytidylate_kin PF02224.18 CDL00795.1 - 0.045 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase AAA PF00004.29 CDL00795.1 - 0.057 13.8 0.2 1.6 9.1 0.2 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 CDL00795.1 - 0.063 13.4 0.1 0.15 12.1 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDL00795.1 - 0.066 13.1 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 CDL00795.1 - 0.071 12.7 0.0 0.23 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDL00795.1 - 0.091 13.3 0.3 0.27 11.8 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDL00795.1 - 0.11 12.6 0.1 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDL00795.1 - 0.12 12.6 1.0 2.8 8.2 0.1 3.0 2 1 1 3 3 3 0 AAA domain AAA_29 PF13555.6 CDL00795.1 - 0.16 11.7 3.5 0.074 12.8 0.6 2.0 2 0 0 2 2 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CDL00795.1 - 0.16 12.4 0.1 0.45 11.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain Pentapeptide PF00805.22 CDL00796.1 - 1.1e-40 136.8 32.3 2.7e-11 42.8 0.8 4.3 1 1 5 6 6 6 6 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 CDL00796.1 - 9.9e-14 51.2 0.0 3.9e-05 23.7 0.0 3.3 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.6 CDL00796.1 - 2.5e-11 43.6 0.0 8.7e-06 25.8 0.0 2.9 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Response_reg PF00072.24 CDL00796.1 - 0.00034 20.8 0.0 0.00067 19.8 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Adeno_E3_14_5 PF04834.12 CDL00796.1 - 0.65 10.6 4.3 1.6 9.3 4.3 1.7 1 0 0 1 1 1 0 Early E3 14.5 kDa protein HATPase_c PF02518.26 CDL00797.1 - 4.1e-24 85.3 0.0 9.9e-24 84.0 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDL00797.1 - 8e-12 45.0 0.8 3.6e-11 42.9 0.0 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain sCache_3_2 PF17203.4 CDL00797.1 - 0.16 12.1 3.6 0.11 12.7 0.9 2.3 2 1 0 2 2 2 0 Single cache domain 3 dCache_1 PF02743.18 CDL00797.1 - 0.18 11.5 0.0 0.44 10.3 0.0 1.6 1 1 0 1 1 1 0 Cache domain Peptidase_M24 PF00557.24 CDL00798.1 - 4.3e-48 163.8 0.0 6e-48 163.3 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 CDL00798.1 - 5.6e-34 117.6 0.0 4.9e-33 114.5 0.0 2.3 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Creatinase_N PF01321.18 CDL00798.1 - 7.1e-24 84.9 0.0 1.2e-19 71.3 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 CDL00798.1 - 1e-21 76.8 0.1 2.3e-21 75.6 0.1 1.7 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Autoind_bind PF03472.15 CDL00798.1 - 0.057 12.9 0.5 0.37 10.3 0.0 2.2 2 0 0 2 2 2 0 Autoinducer binding domain tRNA_edit PF04073.15 CDL00799.1 - 1.2e-26 93.1 0.0 1.5e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain sCache_2 PF17200.4 CDL00800.1 - 2.3e-41 141.2 1.4 3.9e-41 140.5 0.0 2.1 2 0 0 2 2 2 1 Single Cache domain 2 dCache_2 PF08269.11 CDL00800.1 - 2.4e-40 138.6 0.0 2.4e-40 138.6 0.0 2.2 3 0 0 3 3 3 1 Cache domain MCPsignal PF00015.21 CDL00800.1 - 9.8e-29 100.4 51.4 1.2e-27 96.9 25.7 3.8 2 1 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDL00800.1 - 8e-14 51.8 4.8 2e-11 44.1 0.1 4.5 3 1 1 4 4 4 1 HAMP domain Cache_3-Cache_2 PF17201.4 CDL00800.1 - 9.1e-12 44.8 0.0 9.1e-12 44.8 0.0 3.4 3 0 0 3 3 3 1 Cache 3/Cache 2 fusion domain DUF948 PF06103.11 CDL00800.1 - 0.00016 21.9 33.9 0.065 13.5 5.6 6.9 3 2 2 6 6 6 3 Bacterial protein of unknown function (DUF948) Synaphin PF05835.12 CDL00800.1 - 0.012 15.9 3.6 0.031 14.6 3.6 1.7 1 0 0 1 1 1 0 Synaphin protein GAPES1 PF17155.4 CDL00800.1 - 0.19 11.0 0.2 0.33 10.2 0.2 1.5 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain dCache_1 PF02743.18 CDL00800.1 - 0.22 11.3 0.0 0.22 11.3 0.0 3.0 3 0 0 3 3 3 0 Cache domain CorA PF01544.18 CDL00800.1 - 0.67 9.2 4.9 2.2 7.5 3.0 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein PIN_8 PF18476.1 CDL00800.1 - 1.9 8.3 8.6 0.58 10.0 2.6 2.4 1 1 1 2 2 2 0 PIN like domain DUF1664 PF07889.12 CDL00800.1 - 3.8 7.6 17.5 2.8 8.0 2.8 4.2 2 2 4 6 6 6 0 Protein of unknown function (DUF1664) Mur_ligase_C PF02875.21 CDL00800.1 - 4.6 7.6 6.2 19 5.6 0.1 4.0 5 0 0 5 5 5 0 Mur ligase family, glutamate ligase domain Hydantoinase_B PF02538.14 CDL00801.1 - 3.4e-206 685.7 3.4 4.9e-206 685.1 3.4 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 CDL00801.1 - 3.2e-113 377.8 0.7 6.4e-113 376.8 0.7 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 CDL00801.1 - 1e-61 207.7 0.0 1.9e-59 200.3 0.0 2.6 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region TPR_12 PF13424.6 CDL00802.1 - 9e-19 67.5 41.2 1.6e-11 44.3 5.5 4.8 1 1 2 5 5 5 4 Tetratricopeptide repeat SNAP PF14938.6 CDL00802.1 - 1.9e-11 43.9 10.3 5.6e-09 35.8 0.4 3.2 1 1 1 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 CDL00802.1 - 1.2e-10 40.6 31.7 0.024 14.7 0.5 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 CDL00802.1 - 9.4e-10 37.9 12.9 0.0011 18.7 0.0 6.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDL00802.1 - 1.5e-06 27.9 27.1 0.11 12.4 0.1 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDL00802.1 - 0.00067 19.3 1.8 2 8.1 0.0 4.8 6 0 0 6 6 5 1 TPR repeat SRP68 PF16969.5 CDL00802.1 - 0.00074 18.6 0.6 0.015 14.3 0.0 2.7 2 2 0 2 2 2 1 RNA-binding signal recognition particle 68 TPR_8 PF13181.6 CDL00802.1 - 0.00085 19.4 7.2 0.34 11.2 0.0 6.4 9 1 0 9 9 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CDL00802.1 - 0.0015 18.0 22.6 0.0048 16.3 15.6 2.3 1 1 1 2 2 2 2 MalT-like TPR region TPR_7 PF13176.6 CDL00802.1 - 0.0015 18.4 22.0 2.1 8.6 0.3 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDL00802.1 - 0.0058 17.2 16.4 9.2 7.2 0.0 6.9 7 1 0 7 7 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDL00802.1 - 0.019 15.4 3.0 0.019 15.4 3.0 6.0 2 2 4 6 6 6 0 Tetratricopeptide repeat Exo_endo_phos_2 PF14529.6 CDL00802.1 - 0.051 13.4 0.0 0.09 12.6 0.0 1.3 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase DUF2225 PF09986.9 CDL00802.1 - 0.091 12.5 0.0 0.54 10.0 0.0 2.1 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_14 PF13428.6 CDL00802.1 - 0.2 12.5 43.3 0.1 13.5 2.3 7.6 1 1 7 8 8 8 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 CDL00802.1 - 4.1 7.3 12.5 17 5.3 0.1 4.2 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal TPR_16 PF13432.6 CDL00802.1 - 5 7.9 50.8 0.12 13.0 8.9 6.0 3 2 2 6 6 6 0 Tetratricopeptide repeat Pentapeptide PF00805.22 CDL00803.1 - 1.3e-26 91.8 9.3 1.3e-11 43.9 0.5 3.6 1 1 2 4 4 4 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 CDL00803.1 - 5.6e-12 45.7 0.0 8.6e-06 25.8 0.0 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 CDL00803.1 - 5.6e-10 39.2 0.0 0.00034 20.7 0.0 3.5 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF4242 PF14026.6 CDL00803.1 - 0.2 11.8 0.0 0.87 9.8 0.0 2.0 2 2 0 2 2 2 0 Protein of unknown function (DUF4242) GGDEF PF00990.21 CDL00804.1 - 9.5e-46 155.5 0.7 2.7e-45 154.0 0.3 1.9 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain GGDEF_2 PF17853.1 CDL00804.1 - 0.096 12.9 0.1 1.2 9.4 0.0 2.5 2 0 0 2 2 2 0 GGDEF-like domain DUF1319 PF07028.11 CDL00804.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) Csm1_N PF18504.1 CDL00804.1 - 0.15 12.4 1.6 0.23 11.8 0.6 1.8 2 0 0 2 2 2 0 Csm1 N-terminal domain RNase_T PF00929.24 CDL00805.1 - 1e-17 65.2 0.0 1.2e-17 65.0 0.0 1.0 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 CDL00805.1 - 6.3e-05 23.0 0.0 0.00014 21.9 0.0 1.5 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like DUF2059 PF09832.9 CDL00806.1 - 4.3e-14 52.3 3.2 4.7e-14 52.2 0.1 2.5 2 1 1 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2059) CitMHS PF03600.16 CDL00807.1 - 2.2e-24 86.2 32.2 2.2e-24 86.2 32.2 1.4 1 1 0 1 1 1 1 Citrate transporter NhaB PF06450.12 CDL00807.1 - 0.082 11.7 0.2 0.082 11.7 0.2 3.0 3 0 0 3 3 3 0 Bacterial Na+/H+ antiporter B (NhaB) Fumarate_red_C PF02300.17 CDL00807.1 - 1.9 8.6 5.0 0.4 10.8 1.0 1.9 2 0 0 2 2 2 0 Fumarate reductase subunit C PetM PF08041.11 CDL00807.1 - 7.9 6.2 8.3 0.39 10.3 0.6 2.9 2 0 0 2 2 2 0 PetM family of cytochrome b6f complex subunit 7 Guanylate_cyc PF00211.20 CDL00809.1 - 7.4e-21 74.6 0.0 1.7e-20 73.5 0.0 1.5 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain CHASE8 PF17152.4 CDL00809.1 - 0.12 12.6 2.9 0.46 10.7 0.2 2.6 3 0 0 3 3 3 0 Periplasmic sensor domain PseudoU_synth_2 PF00849.22 CDL00810.1 - 1e-30 107.0 0.0 1.3e-30 106.6 0.0 1.1 1 0 0 1 1 1 1 RNA pseudouridylate synthase AAA_2 PF07724.14 CDL00811.1 - 2e-48 164.7 0.0 1.2e-46 159.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CDL00811.1 - 6.7e-28 96.7 2.3 1.4e-27 95.6 2.3 1.6 1 0 0 1 1 1 1 AAA lid domain ClpB_D2-small PF10431.9 CDL00811.1 - 2.2e-25 88.5 0.1 8e-25 86.7 0.1 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CDL00811.1 - 9.6e-25 87.5 0.0 1.7e-11 44.6 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDL00811.1 - 2.4e-18 66.5 0.0 2.1e-13 50.5 0.0 3.1 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDL00811.1 - 2.2e-11 44.4 5.5 0.00024 21.6 0.0 4.3 4 0 0 4 4 4 2 AAA ATPase domain Clp_N PF02861.20 CDL00811.1 - 4.9e-09 36.2 0.5 1.3e-08 34.9 0.5 1.8 1 0 0 1 1 1 1 Clp amino terminal domain, pathogenicity island component Sigma54_activat PF00158.26 CDL00811.1 - 8.7e-08 32.0 0.0 4e-05 23.4 0.0 2.6 2 1 0 2 2 2 1 Sigma-54 interaction domain RuvB_N PF05496.12 CDL00811.1 - 3.9e-07 29.9 1.3 0.018 14.8 0.0 4.2 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 CDL00811.1 - 3e-06 26.8 0.1 0.057 12.8 0.0 3.4 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CDL00811.1 - 1.6e-05 25.2 3.7 0.03 14.6 1.0 4.5 3 2 0 3 3 3 1 AAA domain AAA_3 PF07726.11 CDL00811.1 - 2.7e-05 24.0 0.0 0.0015 18.4 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDL00811.1 - 3.3e-05 24.4 0.0 0.043 14.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 CDL00811.1 - 0.00013 21.5 0.0 0.44 9.9 0.0 3.6 2 1 0 2 2 2 1 Bacterial TniB protein TIP49 PF06068.13 CDL00811.1 - 0.00015 21.1 0.0 0.66 9.1 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_7 PF12775.7 CDL00811.1 - 0.00026 20.6 0.0 1.2 8.6 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region RNA_helicase PF00910.22 CDL00811.1 - 0.00098 19.5 0.0 0.85 10.0 0.0 3.1 3 0 0 3 3 3 1 RNA helicase TsaE PF02367.17 CDL00811.1 - 0.001 19.1 0.0 0.12 12.4 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_6 PF12774.7 CDL00811.1 - 0.0013 17.8 0.0 0.003 16.6 0.0 1.5 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region IstB_IS21 PF01695.17 CDL00811.1 - 0.0016 18.2 0.0 0.66 9.7 0.0 2.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_25 PF13481.6 CDL00811.1 - 0.0024 17.5 0.3 0.38 10.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain Torsin PF06309.11 CDL00811.1 - 0.0025 17.9 0.0 0.0065 16.6 0.0 1.7 1 0 0 1 1 1 1 Torsin NACHT PF05729.12 CDL00811.1 - 0.0076 16.2 0.0 0.66 9.9 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 CDL00811.1 - 0.0077 16.4 0.2 1.7 8.8 0.0 3.0 3 0 0 3 3 2 1 AAA domain ResIII PF04851.15 CDL00811.1 - 0.014 15.4 0.1 0.27 11.2 0.0 2.7 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit TFIIB_C_1 PF18542.1 CDL00811.1 - 0.046 13.7 0.0 0.19 11.8 0.0 2.1 1 0 0 1 1 1 0 Transcription factor IIB C-terminal module 1 DNA_pol3_delta2 PF13177.6 CDL00811.1 - 0.051 13.4 0.0 0.62 9.8 0.0 2.7 4 0 0 4 4 3 0 DNA polymerase III, delta subunit AAA_28 PF13521.6 CDL00811.1 - 0.096 12.9 0.0 2.6 8.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain SPO22 PF08631.10 CDL00811.1 - 0.097 12.1 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like Sigma54_activ_2 PF14532.6 CDL00811.1 - 0.12 12.5 0.0 34 4.5 0.0 3.3 3 0 0 3 3 3 0 Sigma-54 interaction domain Rad17 PF03215.15 CDL00811.1 - 0.16 11.9 0.0 0.48 10.3 0.0 1.8 2 0 0 2 2 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 CDL00811.1 - 1.3 8.8 4.0 19 5.1 0.1 3.3 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea ClpS PF02617.17 CDL00812.1 - 4.9e-36 122.4 0.6 7.9e-36 121.7 0.6 1.3 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS Phasin_2 PF09361.10 CDL00813.1 - 2.8e-19 69.2 3.2 2.8e-19 69.2 3.2 2.3 2 1 1 3 3 3 1 Phasin protein OHCU_decarbox PF09349.10 CDL00813.1 - 0.14 12.6 3.4 0.8 10.2 3.4 2.0 1 1 0 1 1 1 0 OHCU decarboxylase Peptidase_S11 PF00768.20 CDL00815.1 - 2e-54 184.6 0.0 2.7e-54 184.1 0.0 1.2 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 CDL00815.1 - 1.2e-11 44.6 0.5 2.5e-11 43.6 0.1 1.7 2 0 0 2 2 2 1 Beta-lactamase enzyme family SPOR PF05036.13 CDL00815.1 - 1.7e-07 31.5 1.4 1.7e-07 31.5 1.4 2.2 3 0 0 3 3 3 1 Sporulation related domain Beta-lactamase PF00144.24 CDL00815.1 - 0.0079 15.5 2.7 0.056 12.7 0.0 2.4 2 1 0 2 2 2 1 Beta-lactamase Flavodoxin_1 PF00258.25 CDL00815.1 - 0.12 12.6 1.4 7.6 6.7 0.3 2.8 2 1 1 3 3 3 0 Flavodoxin Pyr_redox_2 PF07992.14 CDL00816.1 - 3.9e-73 246.3 12.9 5.1e-73 245.9 12.9 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDL00816.1 - 6.2e-38 129.4 0.1 6.2e-38 129.4 0.1 3.0 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDL00816.1 - 1e-21 77.3 13.1 2.6e-21 76.0 1.2 3.2 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDL00816.1 - 1.3e-12 47.7 10.3 9.3e-10 38.2 0.4 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDL00816.1 - 1e-08 35.0 9.0 1e-08 35.0 9.0 3.1 2 2 0 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 CDL00816.1 - 3.2e-07 29.8 15.3 6.3e-06 25.5 11.0 3.0 2 1 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 CDL00816.1 - 9e-07 27.9 15.1 8.6e-05 21.4 1.8 4.2 3 1 1 4 4 4 2 HI0933-like protein FAD_binding_2 PF00890.24 CDL00816.1 - 1.8e-06 27.3 19.4 2.7e-06 26.7 3.3 4.4 4 1 1 5 5 5 2 FAD binding domain NAD_binding_8 PF13450.6 CDL00816.1 - 6.8e-06 26.2 6.6 0.00015 21.9 1.8 2.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CDL00816.1 - 1.1e-05 24.8 12.1 0.012 14.9 1.4 3.3 2 1 1 3 3 3 3 FAD binding domain K_oxygenase PF13434.6 CDL00816.1 - 2.5e-05 23.6 2.3 0.062 12.4 0.1 2.6 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.21 CDL00816.1 - 9.2e-05 21.8 7.3 0.048 12.9 0.1 3.6 3 1 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CDL00816.1 - 0.0001 21.6 0.7 0.0001 21.6 0.7 2.6 2 1 0 2 2 2 1 Thi4 family Amino_oxidase PF01593.24 CDL00816.1 - 0.0021 17.4 2.2 0.1 11.9 0.1 2.5 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase DAO PF01266.24 CDL00816.1 - 0.0026 17.4 23.5 0.095 12.3 0.0 4.2 3 1 0 4 4 4 2 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CDL00816.1 - 0.0062 16.4 0.3 0.032 14.1 0.5 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 CDL00816.1 - 0.091 11.8 6.3 1.2 8.1 1.4 3.0 2 2 1 3 3 3 0 Lycopene cyclase protein Mqo PF06039.15 CDL00816.1 - 0.25 9.9 1.8 5.7 5.4 0.1 2.2 1 1 1 2 2 2 0 Malate:quinone oxidoreductase (Mqo) 2-oxoacid_dh PF00198.23 CDL00817.1 - 9e-82 274.0 0.0 1.1e-81 273.7 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CDL00817.1 - 2.2e-23 81.8 2.1 2.2e-23 81.8 2.1 2.0 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 CDL00817.1 - 5.1e-09 36.3 1.2 2e-08 34.4 1.2 2.1 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 CDL00817.1 - 0.012 15.4 2.1 8 6.4 0.0 3.4 2 1 1 3 3 3 0 Biotin-lipoyl like GCV_H PF01597.19 CDL00817.1 - 0.02 14.8 0.6 0.044 13.7 0.6 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein RnfC_N PF13375.6 CDL00817.1 - 0.074 13.0 1.8 2.5 8.1 0.4 2.6 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain HlyD_D23 PF16576.5 CDL00817.1 - 0.14 11.3 0.4 2.5 7.2 0.2 2.3 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion DUF4813 PF16072.5 CDL00817.1 - 0.38 10.4 36.0 0.66 9.6 36.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Transket_pyr PF02779.24 CDL00818.1 - 2e-65 219.8 0.0 3.5e-65 219.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 CDL00818.1 - 2.4e-60 204.0 0.5 3.8e-59 200.1 0.0 2.1 2 0 0 2 2 2 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 CDL00818.1 - 1.6e-53 180.5 0.0 2.8e-53 179.7 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 CDL00818.1 - 6.4e-16 57.7 0.0 1.5e-15 56.5 0.0 1.7 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus DUF501 PF04417.12 CDL00818.1 - 0.013 15.3 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF501) CoA_binding PF02629.19 CDL00819.1 - 2.6e-31 108.2 1.9 4e-31 107.6 0.4 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 CDL00819.1 - 3.1e-18 66.0 0.4 4.5e-18 65.5 0.4 1.2 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CDL00819.1 - 3.6e-10 39.8 0.1 5.9e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CDL00819.1 - 0.0066 16.9 0.1 0.028 14.9 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain Phage_GPO PF05929.11 CDL00819.1 - 0.049 13.2 0.0 0.075 12.6 0.0 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase ATP-grasp_2 PF08442.10 CDL00820.1 - 1.2e-79 266.6 3.1 1.2e-79 266.6 1.4 1.8 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 CDL00820.1 - 1e-27 96.9 0.8 1.9e-27 96.0 0.8 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 CDL00820.1 - 5.7e-12 45.6 1.6 5.7e-12 45.6 1.6 2.4 2 1 0 2 2 2 1 ATP-grasp domain Ldh_1_N PF00056.23 CDL00821.1 - 3.8e-41 140.5 1.2 6e-41 139.8 1.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CDL00821.1 - 2.5e-29 102.3 0.0 3.4e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 CDL00821.1 - 8.6e-05 22.2 0.3 0.002 17.7 0.1 2.2 1 1 1 2 2 2 1 Family 4 glycosyl hydrolase UDPG_MGDP_dh_N PF03721.14 CDL00821.1 - 0.005 16.4 1.2 0.02 14.5 1.2 1.8 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CDL00821.1 - 0.058 13.4 0.1 2.9 7.9 0.0 2.4 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 CDL00821.1 - 2.2 8.9 5.4 4.9 7.8 2.2 3.1 2 1 1 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent SRP54 PF00448.22 CDL00822.1 - 2.3e-71 239.5 1.5 3.1e-71 239.1 1.5 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 CDL00822.1 - 3.6e-09 36.7 1.0 9.2e-09 35.4 1.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_30 PF13604.6 CDL00822.1 - 1.8e-07 31.1 0.3 3.9e-07 30.0 0.3 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CDL00822.1 - 2.2e-06 27.1 0.1 4.4e-06 26.1 0.1 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 CDL00822.1 - 1.6e-05 25.4 0.8 3.2e-05 24.4 0.3 1.8 1 1 1 2 2 2 1 AAA ATPase domain AAA_17 PF13207.6 CDL00822.1 - 4.2e-05 24.0 0.2 0.00012 22.5 0.2 1.7 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 CDL00822.1 - 0.00011 21.3 3.2 0.00063 18.8 3.2 2.1 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 CDL00822.1 - 0.00014 21.5 1.5 0.00033 20.3 1.5 1.6 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CDL00822.1 - 0.00042 20.6 0.7 0.0016 18.7 0.2 2.2 2 2 0 2 2 2 1 AAA domain CbiA PF01656.23 CDL00822.1 - 0.00045 20.3 0.0 0.0015 18.6 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_19 PF13245.6 CDL00822.1 - 0.00048 20.5 0.1 0.00085 19.7 0.1 1.5 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 CDL00822.1 - 0.0014 18.6 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP_bind_1 PF03029.17 CDL00822.1 - 0.0014 18.5 1.3 0.0037 17.1 0.5 1.9 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 CDL00822.1 - 0.0032 17.6 0.1 0.0071 16.5 0.1 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CDL00822.1 - 0.0036 17.8 0.1 0.0073 16.8 0.1 1.6 1 1 0 1 1 1 1 ABC transporter Thymidylate_kin PF02223.17 CDL00822.1 - 0.014 15.1 0.2 0.026 14.2 0.2 1.4 1 0 0 1 1 1 0 Thymidylate kinase VirE PF05272.11 CDL00822.1 - 0.014 15.1 0.0 0.03 14.1 0.0 1.5 1 0 0 1 1 1 0 Virulence-associated protein E AAA PF00004.29 CDL00822.1 - 0.016 15.7 0.2 0.037 14.4 0.1 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 CDL00822.1 - 0.023 14.6 0.6 0.045 13.7 0.1 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF4185 PF13810.6 CDL00822.1 - 0.035 13.3 0.1 0.054 12.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4185) SIS_2 PF13580.6 CDL00822.1 - 0.042 13.9 0.2 2 8.5 0.0 2.5 2 0 0 2 2 2 0 SIS domain AAA_7 PF12775.7 CDL00822.1 - 0.049 13.1 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 CDL00822.1 - 0.08 12.9 0.9 0.31 10.9 0.3 2.1 2 0 0 2 2 2 0 NACHT domain NTPase_1 PF03266.15 CDL00822.1 - 0.097 12.6 1.3 0.48 10.3 0.3 2.3 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 CDL00822.1 - 0.12 12.4 0.1 0.29 11.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDL00822.1 - 0.13 12.5 0.1 0.26 11.5 0.1 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDL00822.1 - 0.13 11.5 0.1 2.8 7.2 0.0 2.2 2 0 0 2 2 2 0 KaiC KTI12 PF08433.10 CDL00822.1 - 0.16 11.4 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Radical_SAM PF04055.21 CDL00823.1 - 5.4e-25 88.7 0.1 1.5e-22 80.7 0.0 2.4 2 0 0 2 2 2 2 Radical SAM superfamily UPF0004 PF00919.20 CDL00823.1 - 9.4e-18 64.1 0.3 1.9e-17 63.1 0.3 1.5 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 B12-binding PF02310.19 CDL00823.1 - 0.037 14.1 0.1 0.13 12.3 0.1 2.0 2 0 0 2 2 2 0 B12 binding domain VWA_3 PF13768.6 CDL00823.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF356 PF04009.12 CDL00823.1 - 0.22 11.8 0.8 0.71 10.2 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF356) DAP_epimerase PF01678.19 CDL00824.1 - 3e-57 192.1 0.1 1.9e-27 95.8 0.0 2.0 2 0 0 2 2 2 2 Diaminopimelate epimerase NIT PF08376.10 CDL00825.1 - 1.6e-50 172.8 4.4 1.6e-50 172.8 4.4 4.4 4 1 1 5 5 4 1 Nitrate and nitrite sensing MCPsignal PF00015.21 CDL00825.1 - 1.6e-31 109.5 44.0 4.6e-30 104.7 29.2 2.9 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain Hemerythrin PF01814.23 CDL00825.1 - 1.2e-09 38.9 4.1 1.2e-09 38.9 4.1 3.7 3 2 0 3 3 3 1 Hemerythrin HHE cation binding domain HAMP PF00672.25 CDL00825.1 - 4.2e-06 27.0 0.2 4.2e-06 27.0 0.2 3.4 3 0 0 3 3 3 1 HAMP domain DUF3150 PF11348.8 CDL00825.1 - 0.02 14.1 7.3 0.61 9.3 1.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3150) Matrix PF00661.21 CDL00825.1 - 0.021 13.6 1.7 0.036 12.8 1.7 1.4 1 0 0 1 1 1 0 Viral matrix protein DUF3450 PF11932.8 CDL00825.1 - 0.085 12.2 24.2 0.1 11.9 5.9 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) KASH_CCD PF14662.6 CDL00825.1 - 1.1 9.1 14.0 2.1 8.2 1.2 3.9 4 0 0 4 4 4 0 Coiled-coil region of CCDC155 or KASH BLOC1_2 PF10046.9 CDL00825.1 - 1.1 9.6 9.4 21 5.5 0.5 3.9 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 CDL00825.1 - 1.1 9.2 25.3 0.19 11.8 6.8 3.4 2 1 0 2 2 2 0 Laminin Domain II DUF948 PF06103.11 CDL00825.1 - 7.3 6.9 33.9 0.79 10.0 1.0 6.1 3 1 3 6 6 6 0 Bacterial protein of unknown function (DUF948) Ferritin PF00210.24 CDL00825.1 - 9 6.2 8.6 0.51 10.3 0.5 2.9 3 0 0 3 3 3 0 Ferritin-like domain DUF2786 PF10979.8 CDL00826.1 - 2.7e-05 24.0 1.9 2.7e-05 24.0 1.9 2.4 2 0 0 2 2 1 1 Protein of unknown function (DUF2786) Cnn_1N PF07989.11 CDL00826.1 - 0.0092 16.1 0.4 0.32 11.2 0.1 2.6 2 1 0 2 2 2 1 Centrosomin N-terminal motif 1 betaPIX_CC PF16523.5 CDL00826.1 - 0.014 15.2 0.6 0.056 13.3 0.0 2.2 2 1 1 3 3 3 0 betaPIX coiled coil ATG16 PF08614.11 CDL00826.1 - 0.016 15.5 9.0 0.029 14.6 7.9 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) TSC22 PF01166.18 CDL00826.1 - 0.022 15.1 2.8 0.27 11.6 0.0 2.8 3 0 0 3 3 3 0 TSC-22/dip/bun family Fez1 PF06818.15 CDL00826.1 - 0.031 14.7 4.3 0.037 14.5 2.0 1.9 2 0 0 2 2 2 0 Fez1 bZIP_2 PF07716.15 CDL00826.1 - 0.039 14.0 9.5 2.3 8.4 0.3 3.3 3 0 0 3 3 3 0 Basic region leucine zipper LURAP PF14854.6 CDL00826.1 - 0.048 13.6 1.2 12 5.9 0.0 3.0 3 0 0 3 3 3 0 Leucine rich adaptor protein Spc7 PF08317.11 CDL00826.1 - 0.049 12.5 0.9 0.078 11.8 0.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein YabA PF06156.13 CDL00826.1 - 0.064 13.9 3.0 10 6.8 0.4 2.8 1 1 2 3 3 3 0 Initiation control protein YabA Seryl_tRNA_N PF02403.22 CDL00826.1 - 0.11 12.8 1.4 0.3 11.3 0.1 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 CDL00826.1 - 0.25 11.8 9.2 10 6.7 1.7 3.1 1 1 1 2 2 2 0 Cell division protein ZapB APG6_N PF17675.1 CDL00826.1 - 0.38 11.3 10.4 3.3 8.2 10.1 2.2 1 1 0 1 1 1 0 Apg6 coiled-coil region Shugoshin_N PF07558.11 CDL00826.1 - 0.45 10.4 0.1 0.45 10.4 0.1 2.7 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region NRBF2 PF08961.10 CDL00826.1 - 0.68 9.5 7.3 7 6.2 0.1 3.2 3 0 0 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator CENP-H PF05837.12 CDL00826.1 - 0.8 10.1 7.2 1.1 9.7 3.8 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Uso1_p115_C PF04871.13 CDL00826.1 - 1.1 9.7 5.1 7.2 7.0 2.1 2.6 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region HAP1_N PF04849.13 CDL00826.1 - 1.6 7.9 7.9 10 5.2 7.9 1.9 1 1 0 1 1 1 0 HAP1 N-terminal conserved region DUF4140 PF13600.6 CDL00826.1 - 2.5 8.6 9.1 3.9 8.0 2.3 3.2 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) Glyoxalase PF00903.25 CDL00827.1 - 1.3e-11 44.8 0.0 5.1e-11 42.9 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CDL00827.1 - 3.4e-06 27.3 1.0 0.0007 19.7 1.0 2.5 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CDL00827.1 - 3.3e-05 23.8 0.0 5.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 CDL00827.1 - 8.2e-05 22.8 0.1 0.00035 20.8 0.1 1.9 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CDL00827.1 - 0.024 15.4 0.0 0.032 15.0 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain Asp_decarbox PF02261.16 CDL00828.1 - 3.6e-36 123.6 0.0 4.8e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 Aspartate decarboxylase QueC PF06508.13 CDL00829.1 - 1.5e-76 256.6 0.0 1.7e-76 256.4 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 CDL00829.1 - 4.1e-06 26.7 0.2 5.6e-06 26.2 0.2 1.1 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 CDL00829.1 - 6.7e-06 25.8 0.0 0.02 14.5 0.0 2.1 2 0 0 2 2 2 2 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 CDL00829.1 - 0.013 14.3 0.0 0.018 13.9 0.0 1.1 1 0 0 1 1 1 0 tRNA methyl transferase NAD_synthase PF02540.17 CDL00829.1 - 0.1 11.7 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Abhydrolase_1 PF00561.20 CDL00830.1 - 9.6e-20 71.3 0.0 4.1e-17 62.7 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDL00830.1 - 8e-19 67.8 0.0 5.1e-18 65.2 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDL00830.1 - 1.8e-15 58.2 1.8 2.4e-15 57.8 1.8 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CDL00830.1 - 1.2e-07 31.5 0.0 0.013 15.0 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDL00830.1 - 2.2e-05 24.2 0.2 4.4e-05 23.2 0.2 1.5 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 CDL00830.1 - 0.001 18.7 0.0 0.003 17.1 0.0 1.7 2 0 0 2 2 2 1 Dienelactone hydrolase family FSH1 PF03959.13 CDL00830.1 - 0.0045 16.7 0.0 2.8 7.6 0.0 2.7 3 0 0 3 3 3 2 Serine hydrolase (FSH1) DUF3530 PF12048.8 CDL00830.1 - 0.015 14.7 0.0 0.048 13.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) Abhydrolase_4 PF08386.10 CDL00830.1 - 0.032 14.3 0.0 0.06 13.5 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein BAAT_C PF08840.11 CDL00830.1 - 0.044 13.7 0.0 0.088 12.7 0.0 1.5 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ndr PF03096.14 CDL00830.1 - 0.25 10.0 0.0 0.37 9.4 0.0 1.2 1 0 0 1 1 1 0 Ndr family PepSY_2 PF13670.6 CDL00831.1 - 0.067 13.2 1.3 0.12 12.4 1.3 1.4 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain SNase PF00565.17 CDL00834.1 - 2.9e-07 30.9 0.1 3.7e-07 30.6 0.1 1.1 1 0 0 1 1 1 1 Staphylococcal nuclease homologue NIR_SIR_ferr PF03460.17 CDL00834.1 - 0.082 12.8 0.3 5.5 6.9 0.0 2.9 1 1 2 3 3 3 0 Nitrite/Sulfite reductase ferredoxin-like half domain HTH_Tnp_IS630 PF01710.16 CDL00835.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL00835.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL00835.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL00835.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL00835.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL00835.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDL00836.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL00836.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain CbiA PF01656.23 CDL00838.1 - 1.1e-16 61.1 0.1 1.5e-16 60.7 0.1 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 CDL00838.1 - 6.7e-14 51.9 1.8 1.3e-09 37.9 0.3 2.2 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase AAA_31 PF13614.6 CDL00838.1 - 2.6e-11 43.8 0.0 6.2e-11 42.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain CBP_BcsQ PF06564.12 CDL00838.1 - 5.1e-11 42.5 0.0 1.1e-10 41.4 0.0 1.5 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ArsA_ATPase PF02374.15 CDL00838.1 - 2.4e-06 27.0 1.4 5.1e-05 22.6 0.3 2.3 2 1 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 CDL00838.1 - 0.0016 18.0 0.1 0.018 14.5 0.0 2.0 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family IstB_IS21 PF01695.17 CDL00838.1 - 0.0027 17.5 0.2 0.0047 16.7 0.2 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein CLP1_P PF16575.5 CDL00838.1 - 0.0045 16.8 0.1 0.21 11.3 0.0 2.2 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop VirC1 PF07015.11 CDL00838.1 - 0.0086 15.4 0.1 0.017 14.4 0.1 1.5 1 0 0 1 1 1 1 VirC1 protein MipZ PF09140.11 CDL00838.1 - 0.036 13.3 0.7 0.11 11.8 0.2 1.9 2 0 0 2 2 2 0 ATPase MipZ AAA_25 PF13481.6 CDL00838.1 - 0.1 12.1 0.2 0.1 12.1 0.2 2.1 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 CDL00838.1 - 0.17 11.6 0.1 0.27 10.9 0.1 1.5 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 CDL00839.1 - 2.5e-22 79.5 0.0 3.5e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain IstB_IS21 PF01695.17 CDL00839.1 - 1.6e-05 24.7 0.0 0.00051 19.8 0.0 2.4 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 CDL00839.1 - 0.0011 19.4 1.9 0.0065 16.9 0.2 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CDL00839.1 - 0.0054 16.7 0.0 0.022 14.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDL00839.1 - 0.0064 16.7 0.0 0.02 15.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CDL00839.1 - 0.008 16.5 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CDL00839.1 - 0.018 15.5 0.0 0.036 14.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDL00839.1 - 0.024 14.2 0.3 0.32 10.6 0.1 2.5 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.6 CDL00839.1 - 0.044 14.2 0.0 0.11 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CDL00839.1 - 0.045 13.1 0.0 0.15 11.4 0.0 1.8 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CDL00839.1 - 0.061 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 CDL00839.1 - 0.083 12.8 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 NACHT domain KTI12 PF08433.10 CDL00839.1 - 0.096 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 CDL00839.1 - 0.098 12.4 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDL00839.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain PhoH PF02562.16 CDL00839.1 - 0.12 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Zeta_toxin PF06414.12 CDL00839.1 - 0.12 11.6 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin APS_kinase PF01583.20 CDL00839.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase FHIPEP PF00771.20 CDL00840.1 - 5.8e-221 735.5 0.3 6.6e-221 735.3 0.3 1.0 1 0 0 1 1 1 1 FHIPEP family DFF-C PF09033.10 CDL00840.1 - 0.0093 15.9 0.3 0.018 15.0 0.3 1.4 1 0 0 1 1 1 1 DNA Fragmentation factor 45kDa, C terminal domain FHIPEP PF00771.20 CDL00841.1 - 9.6e-30 103.7 6.6 1.1e-29 103.4 6.6 1.0 1 0 0 1 1 1 1 FHIPEP family Competence PF03772.16 CDL00841.1 - 0.00099 18.5 5.5 0.0014 18.0 5.5 1.2 1 0 0 1 1 1 1 Competence protein SR-25 PF10500.9 CDL00841.1 - 5.5 6.5 11.6 7.1 6.2 11.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sigma54_activat PF00158.26 CDL00842.1 - 8.8e-69 230.5 0.1 1.3e-68 229.9 0.1 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CDL00842.1 - 4.2e-20 72.3 0.0 1.5e-19 70.5 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain HTH_8 PF02954.19 CDL00842.1 - 2.3e-15 56.1 0.0 7.7e-15 54.4 0.0 2.0 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CDL00842.1 - 7.3e-07 29.3 0.0 1.3e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Response_reg PF00072.24 CDL00842.1 - 5.5e-06 26.5 0.1 1.2e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain AAA PF00004.29 CDL00842.1 - 3.3e-05 24.3 0.0 8e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CDL00842.1 - 0.00052 19.5 0.2 0.41 10.0 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDL00842.1 - 0.001 19.0 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CDL00842.1 - 0.0011 18.7 2.3 0.003 17.3 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDL00842.1 - 0.0037 17.7 0.0 0.01 16.3 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain MCM PF00493.23 CDL00842.1 - 0.0051 15.9 0.0 0.012 14.7 0.0 1.5 1 1 0 1 1 1 1 MCM P-loop domain HTH_50 PF18024.1 CDL00842.1 - 0.0074 15.9 0.5 0.023 14.3 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 CDL00842.1 - 0.0079 15.6 0.0 0.017 14.5 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 ATPase PF06745.13 CDL00842.1 - 0.022 14.1 0.1 0.068 12.5 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_19 PF13245.6 CDL00842.1 - 0.024 15.0 0.0 0.66 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CDL00842.1 - 0.047 14.0 0.0 0.15 12.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain HTH_28 PF13518.6 CDL00842.1 - 0.051 13.7 0.0 0.23 11.6 0.0 2.1 2 0 0 2 2 1 0 Helix-turn-helix domain AAA_7 PF12775.7 CDL00842.1 - 0.056 12.9 0.0 0.094 12.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region HTH_23 PF13384.6 CDL00842.1 - 0.097 12.5 0.2 0.33 10.8 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain AAA_PrkA PF08298.11 CDL00842.1 - 0.099 11.5 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain AAA_25 PF13481.6 CDL00842.1 - 0.15 11.6 0.5 12 5.4 0.1 3.2 3 0 0 3 3 3 0 AAA domain HTH_30 PF13556.6 CDL00842.1 - 0.27 11.1 0.1 0.27 11.1 0.1 2.4 3 0 0 3 3 2 0 PucR C-terminal helix-turn-helix domain FliMN_C PF01052.20 CDL00843.1 - 3.5e-25 87.8 2.9 4.3e-25 87.5 2.9 1.1 1 0 0 1 1 1 1 Type III flagellar switch regulator (C-ring) FliN C-term DUF1839 PF08893.10 CDL00843.1 - 0.13 11.4 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1839) FliH PF02108.16 CDL00844.1 - 8.4e-10 38.8 0.4 1.2e-09 38.4 0.4 1.2 1 0 0 1 1 1 1 Flagellar assembly protein FliH MDMPI_N PF11716.8 CDL00844.1 - 8.7 7.0 17.4 0.05 14.3 2.8 2.5 1 1 1 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain FliG_C PF01706.16 CDL00845.1 - 2.1e-42 143.7 17.4 3.1e-40 136.7 4.3 4.6 2 1 3 5 5 5 2 FliG C-terminal domain FliG_N PF14842.6 CDL00845.1 - 4.1e-32 110.8 10.7 5.8e-25 87.8 0.0 3.6 2 1 1 3 3 3 2 FliG N-terminal domain FliG_M PF14841.6 CDL00845.1 - 1.4e-26 92.5 5.2 1.2e-23 83.1 0.5 3.1 4 0 0 4 4 4 2 FliG middle domain MgtE_N PF03448.17 CDL00845.1 - 7e-10 39.4 11.3 0.0029 18.2 0.2 5.2 2 1 3 5 5 5 3 MgtE intracellular N domain IFT81_CH PF18383.1 CDL00845.1 - 0.017 15.4 0.2 0.037 14.3 0.2 1.5 1 0 0 1 1 1 0 Intraflagellar transport 81 calponin homology domain STAS PF01740.21 CDL00845.1 - 0.022 14.4 0.0 0.044 13.4 0.0 1.5 1 0 0 1 1 1 0 STAS domain Importin_rep_3 PF18806.1 CDL00845.1 - 0.13 12.3 0.0 28 4.8 0.0 2.7 2 1 0 2 2 2 0 Importin 13 repeat UCH PF00443.29 CDL00845.1 - 0.15 11.5 0.1 0.21 11.1 0.1 1.3 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase YscJ_FliF PF01514.17 CDL00846.1 - 3.6e-63 212.7 0.3 3.6e-63 212.7 0.3 2.0 2 0 0 2 2 2 1 Secretory protein of YscJ/FliF family YscJ_FliF_C PF08345.11 CDL00846.1 - 4.8e-41 140.6 11.4 4.8e-41 140.6 11.4 2.2 2 0 0 2 2 2 1 Flagellar M-ring protein C-terminal SBP_bac_3 PF00497.20 CDL00847.1 - 1.4e-16 60.7 0.0 1.9e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 PapC_C PF13953.6 CDL00847.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 PapC C-terminal domain GGDEF PF00990.21 CDL00848.1 - 1.5e-45 154.8 0.0 3.5e-45 153.7 0.0 1.6 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain TFA2_Winged_2 PF18121.1 CDL00848.1 - 0.023 14.4 0.1 6.3 6.6 0.0 2.6 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 GGDEF_2 PF17853.1 CDL00848.1 - 2.2 8.6 9.3 0.19 12.0 2.5 2.9 2 2 0 2 2 2 0 GGDEF-like domain PTA_PTB PF01515.19 CDL00849.1 - 1.4e-87 294.0 0.0 2.2e-87 293.3 0.0 1.3 1 0 0 1 1 1 1 Phosphate acetyl/butaryl transferase malic PF00390.19 CDL00849.1 - 2.6e-28 99.1 0.5 1.3e-25 90.3 0.5 2.7 1 1 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.15 CDL00849.1 - 2.4e-22 79.4 0.6 6.2e-22 78.1 0.6 1.6 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain MgtE PF01769.16 CDL00850.1 - 9.1e-28 97.1 5.8 9.1e-28 97.1 5.8 1.7 2 0 0 2 2 2 1 Divalent cation transporter MgtE_N PF03448.17 CDL00850.1 - 1.1e-23 83.7 3.5 1.1e-23 83.7 3.5 2.7 3 0 0 3 3 3 1 MgtE intracellular N domain CBS PF00571.28 CDL00850.1 - 3.5e-12 46.6 1.8 1.5e-06 28.5 1.4 3.0 2 0 0 2 2 2 2 CBS domain FliG_M PF14841.6 CDL00850.1 - 0.11 12.8 4.9 6.8 7.0 0.3 4.0 3 1 1 4 4 4 0 FliG middle domain T4_baseplate PF12322.8 CDL00850.1 - 0.22 11.0 0.0 0.5 9.8 0.0 1.6 1 0 0 1 1 1 0 T4 bacteriophage base plate protein DUF3040 PF11239.8 CDL00850.1 - 0.75 10.1 0.1 0.75 10.1 0.1 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3040) Acetyltransf_3 PF13302.7 CDL00851.1 - 2.1e-13 51.2 0.0 2.3e-13 51.0 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDL00851.1 - 2.2e-08 34.3 0.0 3.3e-08 33.8 0.0 1.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 CDL00851.1 - 4.2e-06 27.0 0.0 5e-06 26.7 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDL00851.1 - 2.4e-05 24.2 0.0 4.3e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 CDL00851.1 - 2.5e-05 24.2 0.0 3.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDL00851.1 - 4e-05 23.9 0.0 5.8e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CDL00851.1 - 0.014 15.1 0.2 0.056 13.1 0.2 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDL00851.1 - 0.08 13.1 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF1674 PF07896.12 CDL00852.1 - 1.3e-14 54.3 5.3 1.5e-14 54.2 5.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1674) Exonuc_VII_L PF02601.15 CDL00853.1 - 2.7e-94 316.2 7.2 8e-78 262.1 0.2 2.1 1 1 1 2 2 2 2 Exonuclease VII, large subunit tRNA_anti_2 PF13742.6 CDL00853.1 - 8.5e-29 99.6 0.0 1.7e-28 98.6 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti-codon PF01336.25 CDL00853.1 - 1.4e-10 41.0 0.0 8.9e-10 38.4 0.0 2.2 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain RecJ_OB PF17768.1 CDL00853.1 - 0.0017 18.6 0.0 0.0029 17.8 0.0 1.3 1 0 0 1 1 1 1 RecJ OB domain GARS_A PF01071.19 CDL00854.1 - 4e-78 261.7 0.0 5.6e-78 261.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 CDL00854.1 - 3.9e-36 123.7 0.3 1.1e-35 122.2 0.1 1.9 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 CDL00854.1 - 1.2e-27 96.0 1.2 3.4e-27 94.5 1.2 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain CPSase_L_D2 PF02786.17 CDL00854.1 - 0.0053 16.3 0.0 0.0087 15.6 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.14 CDL00854.1 - 0.0087 16.1 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain LAL_C2 PF18603.1 CDL00854.1 - 0.01 16.0 3.3 0.075 13.2 1.3 2.6 2 0 0 2 2 2 0 L-amino acid ligase C-terminal domain 2 ATP-grasp PF02222.22 CDL00854.1 - 0.018 14.6 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_4 PF13535.6 CDL00854.1 - 0.22 11.1 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain DNA_alkylation PF08713.11 CDL00855.1 - 1.1e-06 28.5 0.2 2.9e-06 27.1 0.2 1.7 1 1 1 2 2 2 1 DNA alkylation repair enzyme HEAT_2 PF13646.6 CDL00855.1 - 5.4e-05 23.5 4.8 0.0018 18.6 1.6 2.7 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 CDL00855.1 - 0.00023 21.2 0.9 0.24 11.8 0.0 3.6 3 0 0 3 3 3 1 HEAT repeat TetR_C_25 PF17933.1 CDL00855.1 - 0.13 12.6 0.0 4.2 7.7 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain LysR_substrate PF03466.20 CDL00856.1 - 5.1e-37 127.3 2.1 8.5e-37 126.5 2.1 1.3 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDL00856.1 - 3.3e-19 68.6 1.8 8.7e-19 67.2 1.8 1.8 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR_2 PF12802.7 CDL00856.1 - 0.0088 15.9 0.1 0.023 14.6 0.1 1.7 1 0 0 1 1 1 1 MarR family EamA PF00892.20 CDL00857.1 - 2.6e-44 150.7 33.3 4.1e-26 91.8 14.4 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 CDL00857.1 - 6.5e-06 25.7 5.6 1.3e-05 24.7 4.0 2.0 1 1 1 2 2 2 1 Triose-phosphate Transporter family SLC35F PF06027.12 CDL00857.1 - 6.8e-06 25.8 3.1 8.8e-06 25.4 3.1 1.1 1 0 0 1 1 1 1 Solute carrier family 35 DUF3188 PF11384.8 CDL00857.1 - 0.044 13.5 1.1 0.044 13.5 1.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3188) PUNUT PF16913.5 CDL00857.1 - 5.7 6.1 13.2 0.24 10.6 4.5 2.7 2 1 0 2 2 2 0 Purine nucleobase transmembrane transport HlyIII PF03006.20 CDL00857.1 - 9.2 5.9 11.9 0.32 10.7 3.8 2.2 2 0 0 2 2 2 0 Haemolysin-III related EAL PF00563.20 CDL00858.1 - 9.9e-56 188.9 0.0 1.7e-55 188.1 0.0 1.4 1 0 0 1 1 1 1 EAL domain PAS PF00989.25 CDL00858.1 - 0.094 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 PAS fold PAS_4 PF08448.10 CDL00858.1 - 0.12 12.7 0.5 0.34 11.2 0.2 1.9 2 0 0 2 2 2 0 PAS fold HATPase_c PF02518.26 CDL00859.1 - 4.9e-28 97.9 0.1 9e-28 97.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDL00859.1 - 1.6e-21 76.1 0.1 7.8e-21 73.9 0.1 2.3 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDL00859.1 - 1e-11 45.0 0.3 3.6e-11 43.2 0.1 2.2 2 0 0 2 2 2 1 HAMP domain HATPase_c_2 PF13581.6 CDL00859.1 - 0.0067 16.4 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain GlutR_dimer PF00745.20 CDL00859.1 - 0.038 14.4 0.2 0.12 12.8 0.2 1.8 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain D5_N PF08706.11 CDL00859.1 - 0.098 12.9 0.1 1.2 9.3 0.0 2.3 2 0 0 2 2 2 0 D5 N terminal like GT87 PF09594.10 CDL00859.1 - 0.23 11.1 4.8 0.31 10.7 0.2 2.3 2 0 0 2 2 2 0 Glycosyltransferase family 87 DUF3486 PF11985.8 CDL00859.1 - 0.38 11.2 14.0 0.088 13.2 0.6 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3486) DUF4307 PF14155.6 CDL00859.1 - 0.87 9.4 6.0 3.9 7.4 0.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) Response_reg PF00072.24 CDL00860.1 - 1.7e-25 89.4 0.0 1.9e-25 89.2 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain sCache_2 PF17200.4 CDL00861.1 - 2.7e-17 63.1 0.0 3.1e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 Single Cache domain 2 dCache_2 PF08269.11 CDL00861.1 - 2.9e-17 62.8 0.0 3.2e-17 62.6 0.0 1.0 1 0 0 1 1 1 1 Cache domain Cache_3-Cache_2 PF17201.4 CDL00861.1 - 0.00084 18.7 0.0 0.001 18.4 0.0 1.1 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain Response_reg PF00072.24 CDL00862.1 - 9e-25 87.0 0.0 1.1e-24 86.8 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain TrkA_N PF02254.18 CDL00862.1 - 0.023 15.0 0.1 2.8 8.2 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain Hpt PF01627.23 CDL00863.1 - 3.5e-09 36.8 6.0 3.5e-09 36.8 6.0 1.5 2 0 0 2 2 2 1 Hpt domain DUF664 PF04978.12 CDL00863.1 - 0.011 16.1 1.2 0.014 15.8 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF664) HSCB_C PF07743.13 CDL00863.1 - 0.41 11.2 2.9 0.79 10.3 2.9 1.4 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain DUF150 PF02576.17 CDL00864.1 - 4.6e-24 84.6 0.0 8.7e-24 83.7 0.0 1.5 1 0 0 1 1 1 1 RimP N-terminal domain DUF150_C PF17384.2 CDL00864.1 - 3e-13 49.7 0.1 4.7e-13 49.1 0.1 1.3 1 0 0 1 1 1 1 RimP C-terminal SH3 domain NusA_N PF08529.11 CDL00865.1 - 6.5e-37 126.6 1.4 1.5e-36 125.4 1.4 1.7 1 0 0 1 1 1 1 NusA N-terminal domain KH_5 PF13184.6 CDL00865.1 - 3.7e-29 100.6 0.7 2.5e-27 94.8 0.1 2.8 3 0 0 3 3 3 1 NusA-like KH domain HHH_5 PF14520.6 CDL00865.1 - 3e-08 34.1 0.9 0.0017 18.9 0.3 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix domain S1 PF00575.23 CDL00865.1 - 4.6e-06 26.9 0.1 1.5e-05 25.2 0.1 2.0 1 0 0 1 1 1 1 S1 RNA binding domain KH_2 PF07650.17 CDL00865.1 - 3.2e-05 23.7 0.0 0.00037 20.2 0.0 2.6 2 0 0 2 2 2 1 KH domain KH_1 PF00013.29 CDL00865.1 - 0.00041 20.1 0.1 0.015 15.1 0.0 2.7 3 0 0 3 3 3 1 KH domain RlmM_FDX PF18125.1 CDL00865.1 - 0.096 13.2 0.2 2.3 8.8 0.1 2.4 2 0 0 2 2 2 0 RlmM ferredoxin-like domain DUF448 PF04296.13 CDL00866.1 - 5.9e-22 77.3 0.0 1.1e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF448) Ribosomal_L7Ae PF01248.26 CDL00866.1 - 0.00032 20.4 0.1 0.00054 19.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family IF-2 PF11987.8 CDL00867.1 - 3.6e-37 126.7 2.2 3.6e-37 126.7 0.1 2.2 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU PF00009.27 CDL00867.1 - 2.1e-32 112.3 8.6 4e-32 111.4 3.4 2.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF2_N PF04760.15 CDL00867.1 - 1.4e-14 53.6 0.0 3.5e-14 52.3 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region IF2_assoc PF08364.11 CDL00867.1 - 1.5e-14 53.9 3.8 4.1e-14 52.5 3.8 1.8 1 0 0 1 1 1 1 Bacterial translation initiation factor IF-2 associated region MMR_HSR1 PF01926.23 CDL00867.1 - 6.9e-11 42.2 0.1 2.2e-10 40.6 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CDL00867.1 - 4.3e-08 33.4 7.0 3.5e-07 30.5 0.7 4.0 3 1 0 3 3 3 1 Elongation factor Tu domain 2 SRPRB PF09439.10 CDL00867.1 - 1.5e-06 27.7 0.0 7.6e-06 25.5 0.0 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 CDL00867.1 - 2.3e-05 24.0 0.4 6.8e-05 22.5 0.4 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 CDL00867.1 - 7e-05 22.3 0.0 0.00018 21.0 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CDL00867.1 - 0.00033 20.6 2.1 0.065 13.1 0.1 2.7 1 1 1 2 2 2 2 RsgA GTPase Ras PF00071.22 CDL00867.1 - 0.0007 19.2 0.4 0.0015 18.1 0.0 1.8 2 0 0 2 2 2 1 Ras family Roc PF08477.13 CDL00867.1 - 0.0033 17.7 0.0 0.0074 16.5 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 CDL00867.1 - 0.01 15.9 0.0 2 8.5 0.0 2.8 1 1 1 2 2 2 0 Dynamin family PduV-EutP PF10662.9 CDL00867.1 - 0.011 15.5 0.1 0.033 13.9 0.1 1.8 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1_Xtn PF16897.5 CDL00867.1 - 0.014 15.4 0.2 0.079 13.0 0.0 2.3 2 1 1 3 3 3 0 C-terminal region of MMR_HSR1 domain RBFA PF02033.18 CDL00868.1 - 9.3e-29 100.0 0.0 1.2e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Ribosome-binding factor A TruB_N PF01509.18 CDL00869.1 - 1.5e-52 177.9 0.0 2.2e-52 177.4 0.0 1.3 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 CDL00869.1 - 2.3e-12 46.9 0.1 4.6e-12 45.9 0.1 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB-C_2 PF09157.11 CDL00869.1 - 0.0096 15.9 0.1 0.027 14.5 0.1 1.8 1 0 0 1 1 1 1 Pseudouridine synthase II TruB, C-terminal TruB_C PF09142.11 CDL00869.1 - 0.051 13.4 3.6 0.48 10.2 2.0 3.1 2 1 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal Ribosomal_S15 PF00312.22 CDL00870.1 - 1.5e-37 127.6 0.1 1.8e-37 127.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S15 FACT-Spt16_Nlob PF14826.6 CDL00870.1 - 0.0067 16.2 0.0 0.0084 15.9 0.0 1.2 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain RNase_PH PF01138.21 CDL00872.1 - 5.5e-50 169.3 0.0 6.3e-24 85.0 0.0 2.5 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDL00872.1 - 8.3e-19 67.4 1.4 3.3e-10 39.9 0.1 2.6 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 S1 PF00575.23 CDL00872.1 - 1.7e-18 66.7 3.6 5.9e-18 65.0 2.7 2.5 3 0 0 3 3 3 1 S1 RNA binding domain PNPase PF03726.14 CDL00872.1 - 2.3e-14 53.6 0.0 9e-14 51.7 0.0 2.0 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain KH_1 PF00013.29 CDL00872.1 - 8.1e-11 41.6 1.6 5.2e-10 39.0 1.7 2.4 2 0 0 2 2 2 1 KH domain KH_2 PF07650.17 CDL00872.1 - 0.02 14.7 0.5 0.052 13.4 0.5 1.7 1 0 0 1 1 1 0 KH domain Cauli_DNA-bind PF03310.13 CDL00872.1 - 0.095 12.8 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein GDPD PF03009.17 CDL00873.1 - 1.9e-42 145.8 0.0 2.3e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family TraK PF06586.11 CDL00873.1 - 0.071 12.8 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 TraK protein NMO PF03060.15 CDL00874.1 - 2.3e-09 37.1 0.0 6.9e-09 35.5 0.0 1.9 2 1 0 2 2 2 1 Nitronate monooxygenase FUR PF01475.19 CDL00875.1 - 6.4e-21 74.7 0.0 7.1e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 Ferric uptake regulator family HTH_Tnp_Tc3_2 PF01498.18 CDL00875.1 - 0.017 15.4 0.2 0.091 13.0 0.0 2.0 2 0 0 2 2 2 0 Transposase Redoxin PF08534.10 CDL00876.1 - 1.7e-19 70.0 0.0 1.7e-18 66.8 0.0 2.1 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CDL00876.1 - 7.6e-15 54.9 0.0 1.1e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 CDL00876.1 - 5.8e-10 39.4 0.0 3.7e-09 36.8 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like SCO1-SenC PF02630.14 CDL00876.1 - 2.3e-06 27.6 0.0 3.5e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin PF00085.20 CDL00876.1 - 0.00014 21.8 0.0 0.00022 21.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 CDL00876.1 - 0.0046 16.8 0.0 0.006 16.4 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein GSHPx PF00255.19 CDL00876.1 - 0.013 15.1 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 Glutathione peroxidase zf_C2H2_10 PF18414.1 CDL00876.1 - 0.018 14.6 0.4 0.029 13.9 0.4 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger Thioredoxin_7 PF13899.6 CDL00876.1 - 0.044 14.0 0.2 0.15 12.2 0.1 2.0 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_2 PF13098.6 CDL00876.1 - 0.16 12.4 0.0 0.26 11.8 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Lyase_1 PF00206.20 CDL00878.1 - 6.3e-81 272.2 0.0 1.1e-80 271.4 0.0 1.4 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 CDL00878.1 - 6.3e-21 74.9 0.1 1.5e-20 73.7 0.1 1.7 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Orn_Arg_deC_N PF02784.16 CDL00879.1 - 5e-64 216.0 0.0 7e-64 215.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CDL00879.1 - 1.1e-28 99.4 0.0 1.8e-28 98.6 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ala_racemase_N PF01168.20 CDL00879.1 - 6.7e-10 39.0 0.2 1.3e-09 38.1 0.2 1.4 1 1 0 1 1 1 1 Alanine racemase, N-terminal domain DUF4175 PF13779.6 CDL00880.1 - 5e-179 597.0 52.7 2.5e-147 492.1 23.9 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4175) 7TMR-HDED PF07697.11 CDL00880.1 - 0.036 14.2 3.0 3.6 7.6 3.0 2.3 1 1 0 1 1 1 0 7TM-HD extracellular FliS PF02561.14 CDL00880.1 - 0.27 11.5 1.4 2.8 8.3 0.1 2.9 3 0 0 3 3 3 0 Flagellar protein FliS LysE PF01810.18 CDL00880.1 - 0.33 10.4 5.3 0.6 9.5 5.3 1.3 1 0 0 1 1 1 0 LysE type translocator YtpI PF14007.6 CDL00880.1 - 0.48 10.6 1.2 0.91 9.7 1.2 1.4 1 0 0 1 1 1 0 YtpI-like protein YfdX PF10938.8 CDL00880.1 - 0.86 9.5 6.4 0.59 10.1 1.2 2.3 2 0 0 2 2 2 0 YfdX protein 4HBT PF03061.22 CDL00881.1 - 1.2e-11 44.8 0.7 1.9e-11 44.2 0.7 1.3 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 CDL00881.1 - 0.00076 19.6 0.0 0.00095 19.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) 4HBT_3 PF13622.6 CDL00881.1 - 0.0037 17.6 0.3 0.0048 17.2 0.3 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily PS-DH PF14765.6 CDL00881.1 - 0.048 12.9 0.0 0.054 12.7 0.0 1.1 1 0 0 1 1 1 0 Polyketide synthase dehydratase Peptidase_S24 PF00717.23 CDL00883.1 - 4.4e-18 65.0 0.0 8.9e-18 64.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase S24-like HTH_26 PF13443.6 CDL00883.1 - 0.00032 21.1 0.0 0.00082 19.8 0.0 1.7 2 0 0 2 2 2 1 Cro/C1-type HTH DNA-binding domain MarR_2 PF12802.7 CDL00883.1 - 0.0016 18.3 0.0 0.0041 17.0 0.0 1.7 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 CDL00883.1 - 0.016 14.8 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_31 PF13560.6 CDL00883.1 - 0.046 14.1 0.4 0.046 14.1 0.4 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_IclR PF09339.10 CDL00883.1 - 0.05 13.4 0.6 0.15 11.8 0.3 1.9 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_35 PF13693.6 CDL00883.1 - 0.072 13.1 0.1 0.15 12.1 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_Tnp_1 PF01527.20 CDL00883.1 - 0.12 12.7 0.1 0.32 11.3 0.0 1.7 2 0 0 2 2 2 0 Transposase DUF3987 PF13148.6 CDL00884.1 - 0.083 11.9 0.0 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) TBD PF12845.7 CDL00884.1 - 0.14 12.1 0.2 0.22 11.4 0.2 1.3 1 0 0 1 1 1 0 TBD domain Head-tail_con PF12236.8 CDL00887.1 - 7.4e-169 562.2 0.1 8.5e-169 562.0 0.1 1.0 1 0 0 1 1 1 1 Bacteriophage head to tail connecting protein CbiA PF01656.23 CDL00890.1 - 7.5e-13 48.7 0.0 9.1e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDL00890.1 - 3e-10 40.3 0.4 4e-07 30.1 0.1 2.1 1 1 1 2 2 2 2 AAA domain MipZ PF09140.11 CDL00890.1 - 3.2e-08 33.2 2.8 6.5e-07 28.9 0.0 2.5 1 1 1 2 2 2 1 ATPase MipZ TPP_enzyme_M PF00205.22 CDL00890.1 - 4.5e-05 23.2 0.3 8.5e-05 22.3 0.0 1.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain ParA PF10609.9 CDL00890.1 - 9.2e-05 22.0 1.4 0.00023 20.7 0.1 1.9 1 1 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 CDL00890.1 - 0.001 18.7 0.6 0.25 10.9 0.1 2.2 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 CDL00890.1 - 0.014 14.9 0.1 0.035 13.6 0.0 1.7 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ AAA_16 PF13191.6 CDL00890.1 - 0.028 14.8 0.1 0.045 14.1 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain VirC1 PF07015.11 CDL00890.1 - 0.043 13.1 0.2 0.3 10.4 0.1 1.9 2 0 0 2 2 2 0 VirC1 protein AAA_26 PF13500.6 CDL00890.1 - 0.045 13.6 2.4 0.1 12.4 0.1 2.0 2 0 0 2 2 2 0 AAA domain ArsA_ATPase PF02374.15 CDL00890.1 - 0.066 12.4 0.2 0.098 11.8 0.2 1.3 1 0 0 1 1 1 0 Anion-transporting ATPase LpxK PF02606.14 CDL00890.1 - 0.079 12.0 0.2 0.13 11.4 0.2 1.3 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase Fer4_NifH PF00142.18 CDL00890.1 - 0.14 11.6 0.1 0.79 9.1 0.1 1.9 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CLP1_P PF16575.5 CDL00890.1 - 0.14 11.9 0.1 0.32 10.8 0.0 1.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_25 PF13481.6 CDL00890.1 - 0.16 11.5 3.2 0.13 11.8 0.8 2.0 1 1 1 2 2 2 0 AAA domain HTH_Tnp_IS630 PF01710.16 CDL00891.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL00891.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL00891.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL00891.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL00891.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL00891.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 CDL00892.1 - 4.8e-37 126.9 0.0 5.6e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL00892.1 - 0.08 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain DLH PF01738.18 CDL00894.1 - 1.3e-69 234.0 0.0 1.6e-69 233.8 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 CDL00894.1 - 3.4e-05 23.6 0.0 0.00094 18.9 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold BAAT_C PF08840.11 CDL00894.1 - 5.6e-05 23.2 0.0 0.25 11.2 0.0 2.3 1 1 1 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 CDL00894.1 - 0.0018 17.8 0.2 0.88 9.0 0.0 2.2 1 1 0 2 2 2 2 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDL00894.1 - 0.0045 16.6 1.4 0.032 13.8 0.8 2.1 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 CDL00894.1 - 0.011 15.1 0.0 4 6.6 0.0 2.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Esterase_phd PF10503.9 CDL00894.1 - 0.026 14.0 0.1 0.055 13.0 0.1 1.5 1 0 0 1 1 1 0 Esterase PHB depolymerase Chlorophyllase PF07224.11 CDL00894.1 - 0.034 13.2 0.0 0.044 12.8 0.0 1.1 1 0 0 1 1 1 0 Chlorophyllase Abhydrolase_2 PF02230.16 CDL00894.1 - 0.043 13.6 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase TAT_signal PF10518.9 CDL00894.1 - 0.045 13.6 3.1 0.17 11.8 3.1 2.0 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence Abhydrolase_3 PF07859.13 CDL00894.1 - 0.077 12.8 2.0 1.2 8.9 0.2 2.3 1 1 1 2 2 2 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 CDL00894.1 - 0.086 11.7 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF829 PF05705.14 CDL00894.1 - 0.095 12.6 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) Abhydrolase_6 PF12697.7 CDL00894.1 - 5 7.7 8.8 3.2 8.3 6.9 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family MatE PF01554.18 CDL00895.1 - 6.6e-50 168.9 27.1 4.4e-27 94.7 6.0 3.3 4 0 0 4 4 4 2 MatE Polysacc_synt_C PF14667.6 CDL00895.1 - 0.083 12.9 46.8 0.19 11.8 6.7 4.3 2 2 2 4 4 4 0 Polysaccharide biosynthesis C-terminal domain DUF1775 PF07987.11 CDL00895.1 - 0.27 11.5 0.0 0.44 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unkown function (DUF1775) sCache_2 PF17200.4 CDL00896.1 - 4.8e-20 72.0 1.3 8.4e-20 71.2 1.3 1.5 1 1 0 1 1 1 1 Single Cache domain 2 dCache_2 PF08269.11 CDL00896.1 - 1.6e-16 60.4 0.1 1.8e-16 60.2 0.1 1.2 1 0 0 1 1 1 1 Cache domain Cache_3-Cache_2 PF17201.4 CDL00896.1 - 0.00019 20.8 0.1 0.00025 20.4 0.1 1.1 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain EAL PF00563.20 CDL00897.1 - 9.4e-52 175.9 0.0 1.3e-51 175.4 0.0 1.2 1 0 0 1 1 1 1 EAL domain PAS_4 PF08448.10 CDL00897.1 - 7e-07 29.5 0.1 1.8e-06 28.1 0.1 1.7 1 1 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDL00897.1 - 0.11 12.7 0.0 0.33 11.2 0.0 1.8 1 0 0 1 1 1 0 PAS domain Ribosomal_L35p PF01632.19 CDL00898.1 - 1.2e-20 73.7 5.7 1.4e-20 73.5 5.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L35 Ribosomal_L20 PF00453.18 CDL00899.1 - 7.7e-50 167.5 4.3 8.7e-50 167.3 4.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L20 VQ PF05678.14 CDL00899.1 - 0.021 14.3 0.2 0.87 9.1 0.0 2.3 2 0 0 2 2 2 0 VQ motif DDE_Tnp_IS66 PF03050.14 CDL00899.1 - 0.027 14.0 0.0 0.061 12.8 0.0 1.6 1 1 0 1 1 1 0 Transposase IS66 family tRNA-synt_2d PF01409.20 CDL00900.1 - 2.1e-101 338.5 0.0 2.5e-101 338.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) Phe_tRNA-synt_N PF02912.18 CDL00900.1 - 4.9e-20 71.2 2.4 4.9e-20 71.2 2.4 2.0 3 0 0 3 3 3 1 Aminoacyl tRNA synthetase class II, N-terminal domain B3_4 PF03483.17 CDL00901.1 - 9.1e-61 204.5 0.0 1.4e-60 203.9 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain tRNA_synthFbeta PF17759.1 CDL00901.1 - 8.8e-45 152.8 0.0 1.4e-44 152.1 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain FDX-ACB PF03147.14 CDL00901.1 - 8.7e-26 90.2 0.2 2.2e-25 88.9 0.1 1.8 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain tRNA_bind PF01588.20 CDL00901.1 - 5.4e-23 80.9 0.0 1.1e-22 80.0 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain B5 PF03484.15 CDL00901.1 - 2.1e-18 66.4 0.0 8.5e-17 61.2 0.0 2.7 2 1 0 2 2 2 1 tRNA synthetase B5 domain His_Phos_1 PF00300.22 CDL00902.1 - 1.4e-35 122.8 0.0 1.6e-35 122.5 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SBP_bac_3 PF00497.20 CDL00903.1 - 6.5e-08 32.3 0.0 1.6e-07 31.0 0.0 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 SBP_bac_11 PF13531.6 CDL00903.1 - 0.009 15.8 0.1 0.019 14.7 0.1 1.6 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein UbiA PF01040.18 CDL00904.1 - 4e-60 203.2 26.2 4.9e-60 202.9 26.2 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Bcl-2 PF00452.19 CDL00904.1 - 0.15 12.8 2.0 18 6.1 0.1 2.8 3 1 0 3 3 3 0 Apoptosis regulator proteins, Bcl-2 family PrmA PF06325.13 CDL00905.1 - 4e-10 39.6 3.6 6.3e-10 38.9 3.3 1.6 1 1 1 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CDL00905.1 - 1.7e-07 30.9 0.3 2.8e-07 30.2 0.3 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CDL00905.1 - 1.3e-05 24.9 0.0 1.7e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 CDL00905.1 - 2.5e-05 24.2 0.0 3.4e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL00905.1 - 7.6e-05 23.4 0.1 0.00013 22.5 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CDL00905.1 - 0.00015 21.6 0.1 0.00018 21.3 0.1 1.1 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_16 PF10294.9 CDL00905.1 - 0.00043 20.1 0.0 0.00093 19.0 0.0 1.5 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_11 PF08241.12 CDL00905.1 - 0.0042 17.7 0.1 0.0066 17.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL00905.1 - 0.036 13.9 0.0 0.048 13.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain HAGH_C PF16123.5 CDL00906.1 - 1.3e-20 73.7 0.0 1.9e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 CDL00906.1 - 2.8e-19 69.9 6.8 3.7e-18 66.3 6.8 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Raftlin PF15250.6 CDL00906.1 - 0.32 9.7 0.0 0.44 9.2 0.0 1.1 1 0 0 1 1 1 0 Raftlin GST_N_3 PF13417.6 CDL00907.1 - 2.7e-15 56.5 0.0 4.5e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDL00907.1 - 1.7e-13 50.7 0.0 3.2e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDL00907.1 - 1.1e-05 25.7 0.0 2e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CDL00907.1 - 0.00039 20.4 0.3 0.0013 18.7 0.3 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Cupin_5 PF06172.11 CDL00908.1 - 9.5e-46 155.5 0.0 1.1e-45 155.3 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily (DUF985) Glu_synthase PF01645.17 CDL00909.1 - 1.4e-154 514.7 0.1 6.9e-154 512.4 0.0 1.9 2 0 0 2 2 2 1 Conserved region in glutamate synthase GATase_2 PF00310.21 CDL00909.1 - 1.3e-153 511.7 0.0 1.7e-153 511.3 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.14 CDL00909.1 - 3.5e-101 338.4 0.0 1e-100 336.8 0.0 1.8 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 CDL00909.1 - 5.4e-76 254.4 7.3 1e-75 253.6 7.3 1.4 1 0 0 1 1 1 1 GXGXG motif FMN_dh PF01070.18 CDL00909.1 - 0.00029 20.0 0.4 0.002 17.2 0.5 2.2 2 0 0 2 2 2 1 FMN-dependent dehydrogenase GST_N PF02798.20 CDL00910.1 - 1.5e-15 57.2 0.0 2.8e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CDL00910.1 - 2e-12 47.4 0.0 3.9e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDL00910.1 - 2.5e-08 34.0 0.0 4.1e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDL00910.1 - 7.5e-08 32.3 0.4 1.3e-07 31.5 0.4 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CDL00910.1 - 9.2e-07 29.1 0.0 1.8e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CDL00910.1 - 2e-06 27.9 0.0 3.1e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Fer4_20 PF14691.6 CDL00911.1 - 1.9e-33 114.6 0.2 2.8e-33 114.1 0.2 1.2 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 CDL00911.1 - 3.9e-32 111.6 3.8 5.3e-32 111.2 3.8 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDL00911.1 - 3.8e-14 52.7 0.3 4.2e-08 32.8 0.0 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDL00911.1 - 3.3e-13 50.0 2.3 6.1e-06 26.7 0.1 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDL00911.1 - 8.3e-11 42.0 1.0 2.5e-10 40.4 0.3 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CDL00911.1 - 2.9e-05 23.0 1.1 0.00024 20.0 0.2 2.1 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 CDL00911.1 - 8e-05 22.0 3.3 0.00035 19.9 0.4 2.6 3 0 0 3 3 3 1 Thi4 family NAD_binding_7 PF13241.6 CDL00911.1 - 0.00014 22.3 3.4 0.022 15.2 0.7 2.8 2 1 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 CDL00911.1 - 0.00016 21.0 0.2 0.00035 19.9 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CDL00911.1 - 0.00017 21.1 6.3 0.00019 20.9 0.4 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDL00911.1 - 0.00018 20.7 2.0 0.0037 16.4 0.4 2.9 3 0 0 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.21 CDL00911.1 - 0.00035 19.9 0.1 0.29 10.4 0.0 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 CDL00911.1 - 0.0021 17.4 0.2 0.0067 15.8 0.1 1.8 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Transketolase_C PF02780.20 CDL00911.1 - 0.0047 16.8 0.1 7 6.6 0.0 3.8 4 0 0 4 4 4 1 Transketolase, C-terminal domain DAO PF01266.24 CDL00911.1 - 0.011 15.4 0.5 0.011 15.4 0.5 2.5 2 1 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 CDL00911.1 - 0.014 14.5 1.4 0.096 11.7 0.3 2.5 3 0 0 3 3 3 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 CDL00911.1 - 0.015 14.6 0.3 0.06 12.7 0.1 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CDL00911.1 - 0.021 15.0 0.3 0.069 13.3 0.0 2.0 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 CDL00911.1 - 0.021 14.9 0.0 8.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 CDL00911.1 - 0.032 14.2 0.3 0.085 12.8 0.3 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding F420_oxidored PF03807.17 CDL00911.1 - 0.044 14.3 0.3 2 9.1 0.1 2.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent K_oxygenase PF13434.6 CDL00911.1 - 0.045 12.9 0.0 0.21 10.7 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) XdhC_C PF13478.6 CDL00911.1 - 0.058 13.9 0.1 1.6 9.2 0.0 2.6 2 0 0 2 2 2 0 XdhC Rossmann domain NAD_Gly3P_dh_N PF01210.23 CDL00911.1 - 0.066 13.2 0.0 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus YjeF_N PF03853.15 CDL00911.1 - 0.12 12.2 0.3 0.69 9.8 0.0 2.1 2 0 0 2 2 2 0 YjeF-related protein N-terminus BacA PF02673.18 CDL00913.1 - 2.8e-44 151.8 16.4 3.3e-44 151.5 16.4 1.0 1 0 0 1 1 1 1 Bacitracin resistance protein BacA DUF872 PF05915.12 CDL00913.1 - 0.31 11.2 1.0 0.71 10.1 1.0 1.6 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) Extensin-like_C PF06904.12 CDL00914.1 - 1.6e-53 181.4 0.0 1.9e-53 181.1 0.0 1.1 1 0 0 1 1 1 1 Extensin-like protein C-terminus Peptidase_M15_4 PF13539.6 CDL00914.1 - 0.013 16.0 0.0 0.028 14.9 0.0 1.5 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Peptidase_M15_3 PF08291.11 CDL00914.1 - 0.11 12.6 0.1 0.22 11.6 0.1 1.6 1 0 0 1 1 1 0 Peptidase M15 Fer2_BFD PF04324.15 CDL00916.1 - 2.4e-11 43.8 0.8 2.4e-11 43.8 0.8 1.7 2 0 0 2 2 2 1 BFD-like [2Fe-2S] binding domain Ferritin PF00210.24 CDL00917.1 - 3.1e-33 114.7 0.9 3.6e-33 114.5 0.9 1.0 1 0 0 1 1 1 1 Ferritin-like domain Ferritin PF00210.24 CDL00918.1 - 3.9e-37 127.3 5.1 4.5e-37 127.1 5.1 1.0 1 0 0 1 1 1 1 Ferritin-like domain Phage_TAC_12 PF12363.8 CDL00918.1 - 0.073 13.5 0.6 0.13 12.7 0.2 1.7 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC UPF0193 PF05250.11 CDL00918.1 - 0.077 12.8 0.2 0.13 12.0 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0193) Peptidase_S41 PF03572.18 CDL00919.1 - 1.7e-45 154.6 0.1 2.3e-45 154.1 0.1 1.2 1 0 0 1 1 1 1 Peptidase family S41 PDZ_6 PF17820.1 CDL00919.1 - 4.9e-15 55.1 1.2 1.4e-14 53.7 1.2 1.8 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDL00919.1 - 6e-10 39.3 0.3 1.3e-09 38.2 0.3 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDL00919.1 - 2.1e-08 34.4 0.2 7.6e-08 32.6 0.2 2.0 1 0 0 1 1 1 1 PDZ domain DUF732 PF05305.14 CDL00919.1 - 0.0098 16.2 0.8 0.028 14.8 0.8 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF732) Tricorn_PDZ PF14685.6 CDL00919.1 - 0.044 13.7 0.1 0.13 12.2 0.1 1.8 1 0 0 1 1 1 0 Tricorn protease PDZ domain DUF3394 PF11874.8 CDL00919.1 - 0.058 13.1 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) TSP_NTD PF17804.1 CDL00919.1 - 0.077 13.2 0.1 0.13 12.5 0.0 1.3 1 1 0 1 1 1 0 Tail specific protease N-terminal domain MCPsignal PF00015.21 CDL00920.1 - 1.7e-51 174.5 18.8 1.7e-51 174.5 18.8 4.2 2 1 2 4 4 4 1 Methyl-accepting chemotaxis protein (MCP) signalling domain 4HB_MCP_1 PF12729.7 CDL00920.1 - 3.8e-43 147.1 0.1 3.8e-43 147.1 0.1 4.3 4 1 2 6 6 6 1 Four helix bundle sensory module for signal transduction TarH PF02203.15 CDL00920.1 - 5.7e-19 68.7 5.9 5.7e-19 68.7 5.9 5.9 6 1 1 7 7 7 1 Tar ligand binding domain homologue CZB PF13682.6 CDL00920.1 - 2.4e-11 43.9 0.3 4.9e-11 42.9 0.3 1.6 1 0 0 1 1 1 1 Chemoreceptor zinc-binding domain HAMP PF00672.25 CDL00920.1 - 3.2e-09 37.0 26.3 8.2e-08 32.5 0.5 7.0 6 3 2 8 8 8 3 HAMP domain Kre28 PF17097.5 CDL00920.1 - 0.037 13.0 2.1 0.07 12.1 0.1 2.3 2 0 0 2 2 2 0 Spindle pole body component UPF0242 PF06785.11 CDL00920.1 - 0.38 10.8 5.5 53 3.8 0.1 4.2 4 1 0 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 CDL00920.1 - 0.83 9.7 8.0 6.7 6.8 1.5 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) SKA1 PF07160.12 CDL00920.1 - 1.4 8.7 5.6 1 9.2 0.1 3.0 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 CLZ PF16526.5 CDL00920.1 - 7.5 7.0 18.2 1.3 9.5 0.4 5.0 4 1 1 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Spermine_synth PF01564.17 CDL00921.1 - 2.9e-52 176.8 0.0 5e-52 176.0 0.0 1.4 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 CDL00921.1 - 4.1e-12 45.8 0.0 6.9e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 CDL00921.1 - 5.5e-05 23.8 0.0 0.00012 22.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL00921.1 - 0.0092 16.6 0.0 0.029 15.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00921.1 - 0.011 16.4 0.0 0.036 14.8 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain DUF2243 PF10002.9 CDL00921.1 - 0.069 13.3 0.2 0.19 11.9 0.0 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2243) DUF4440 PF14534.6 CDL00921.1 - 0.097 13.1 0.0 0.3 11.5 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) Methyltransf_31 PF13847.6 CDL00921.1 - 0.13 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_PK PF05891.12 CDL00921.1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase AdoMet_dc PF02675.15 CDL00922.1 - 1.2e-33 115.6 0.0 1.5e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 S-adenosylmethionine decarboxylase TPR_16 PF13432.6 CDL00923.1 - 1.1e-05 26.0 24.2 0.42 11.3 5.6 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 CDL00923.1 - 0.16 12.2 9.6 12 6.3 0.0 5.1 6 1 1 7 7 7 0 Tetratricopeptide repeat FAM92 PF06730.11 CDL00923.1 - 0.21 11.0 0.0 0.38 10.1 0.0 1.3 1 0 0 1 1 1 0 FAM92 protein TPR_1 PF00515.28 CDL00923.1 - 0.25 11.2 0.8 3.5 7.6 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Paf67 PF10255.9 CDL00923.1 - 0.28 10.1 0.0 0.95 8.4 0.0 1.7 2 0 0 2 2 2 0 RNA polymerase I-associated factor PAF67 TPR_6 PF13174.6 CDL00923.1 - 1.3 9.9 10.3 8.4 7.3 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDL00923.1 - 1.4 9.5 21.7 13 6.4 0.1 5.2 3 2 1 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDL00923.1 - 2.6 9.1 29.9 5.3 8.1 0.2 7.4 7 1 0 7 7 7 0 Tetratricopeptide repeat CheZ PF04344.13 CDL00924.1 - 3.2e-16 59.8 0.9 2.4e-11 43.9 0.1 2.2 1 1 1 2 2 2 2 Chemotaxis phosphatase, CheZ SH3BP5 PF05276.14 CDL00924.1 - 0.033 14.0 0.1 0.045 13.5 0.1 1.2 1 0 0 1 1 1 0 SH3 domain-binding protein 5 (SH3BP5) Response_reg PF00072.24 CDL00925.1 - 5.8e-29 100.5 0.1 6.5e-29 100.4 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Secretin_N PF03958.17 CDL00925.1 - 0.059 13.8 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Bacterial type II/III secretion system short domain Ceramidase_alk PF04734.13 CDL00925.1 - 0.13 10.9 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Neutral/alkaline non-lysosomal ceramidase, N-terminal ApoB100_C PF12491.8 CDL00925.1 - 0.16 12.0 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein B100 C terminal MgtE_N PF03448.17 CDL00926.1 - 1.4e-06 28.9 0.7 1.4e-06 28.9 0.7 2.0 2 0 0 2 2 2 1 MgtE intracellular N domain FliG_M PF14841.6 CDL00926.1 - 0.0097 16.1 3.3 0.48 10.7 0.0 3.1 3 1 1 4 4 4 1 FliG middle domain Phage_min_cap2 PF06152.11 CDL00926.1 - 0.046 12.6 6.1 0.65 8.8 0.1 2.1 1 1 1 2 2 2 0 Phage minor capsid protein 2 Death PF00531.22 CDL00926.1 - 0.071 13.3 0.8 0.25 11.5 0.2 2.1 2 1 0 2 2 2 0 Death domain POX PF07526.11 CDL00926.1 - 0.079 13.5 0.7 0.12 12.9 0.7 1.3 1 0 0 1 1 1 0 Associated with HOX ECM11 PF15463.6 CDL00926.1 - 0.55 10.8 6.2 0.43 11.2 3.0 2.3 2 0 0 2 2 2 0 Extracellular mutant protein 11 DUF3584 PF12128.8 CDL00927.1 - 0.011 13.3 1.3 0.017 12.7 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Jnk-SapK_ap_N PF09744.9 CDL00927.1 - 0.018 15.3 2.2 0.025 14.8 0.2 1.8 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 FlgN PF05130.12 CDL00927.1 - 0.066 13.7 4.1 0.097 13.2 2.5 1.8 2 0 0 2 2 2 0 FlgN protein DegS PF05384.11 CDL00927.1 - 0.08 12.4 3.6 0.36 10.3 1.1 2.3 1 1 1 2 2 2 0 Sensor protein DegS DUF2570 PF10828.8 CDL00927.1 - 0.11 12.3 1.1 13 5.7 1.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2570) DUF4200 PF13863.6 CDL00927.1 - 0.8 10.1 6.7 0.058 13.8 1.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 CDL00927.1 - 0.89 10.1 6.0 0.29 11.6 1.1 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region Herpes_capsid PF06112.11 CDL00927.1 - 1.7 8.7 8.0 2.8 8.0 8.0 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein FliM PF02154.15 CDL00928.1 - 3.2e-66 222.9 0.0 4.3e-66 222.5 0.0 1.1 1 0 0 1 1 1 1 Flagellar motor switch protein FliM FliMN_C PF01052.20 CDL00928.1 - 1.5e-18 66.5 0.0 9.7e-18 63.9 0.0 2.1 2 0 0 2 2 2 1 Type III flagellar switch regulator (C-ring) FliN C-term FliL PF03748.14 CDL00929.1 - 1.5e-17 64.0 0.4 2.3e-17 63.5 0.4 1.3 1 0 0 1 1 1 1 Flagellar basal body-associated protein FliL Flg_bbr_C PF06429.13 CDL00930.1 - 1.3e-12 47.7 2.5 1.7e-12 47.3 1.3 1.8 2 0 0 2 2 2 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CDL00930.1 - 3.8e-09 36.3 0.1 7e-09 35.4 0.1 1.5 1 0 0 1 1 1 1 Flagella basal body rod protein Flg_bbr_C PF06429.13 CDL00931.1 - 2e-27 95.1 0.2 6.4e-27 93.5 0.2 1.9 1 0 0 1 1 1 1 Flagellar basal body rod FlgEFG protein C-terminal Flg_bb_rod PF00460.20 CDL00931.1 - 1.2e-09 37.9 8.6 3.3e-09 36.5 8.6 1.8 1 0 0 1 1 1 1 Flagella basal body rod protein Tobravirus_2B PF05271.11 CDL00931.1 - 0.029 14.3 0.0 5.3 7.0 0.0 2.5 2 1 1 3 3 3 0 Tobravirus 2B protein ChapFlgA PF13144.6 CDL00932.1 - 1.8e-32 112.0 1.9 3.4e-32 111.1 1.9 1.5 1 0 0 1 1 1 1 Chaperone for flagella basal body P-ring formation SAF PF08666.12 CDL00932.1 - 6.1e-11 42.8 2.1 1.5e-10 41.6 1.0 2.3 3 0 0 3 3 3 1 SAF domain BiPBP_C PF06832.12 CDL00932.1 - 0.055 13.5 0.3 0.37 10.9 0.1 2.3 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family FlgH PF02107.16 CDL00933.1 - 2.2e-51 173.8 0.2 2.6e-51 173.6 0.2 1.0 1 0 0 1 1 1 1 Flagellar L-ring protein Pam16 PF03656.13 CDL00934.1 - 8.3e-06 25.8 0.0 1e-05 25.6 0.0 1.1 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 CDL00934.1 - 3.6e-05 23.8 0.0 7.6e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain CcmF_C PF16327.5 CDL00934.1 - 0.038 13.3 0.7 0.042 13.1 0.7 1.1 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal NTP_transferase PF00483.23 CDL00935.1 - 6.8e-28 97.9 0.0 1.7e-27 96.6 0.0 1.4 1 1 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CDL00935.1 - 2.6e-09 37.6 0.1 3.8e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain UDPG_MGDP_dh_N PF03721.14 CDL00936.1 - 1.5e-68 230.1 0.2 2.3e-68 229.5 0.2 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 CDL00936.1 - 1.6e-38 130.8 0.0 7.3e-38 128.7 0.0 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 CDL00936.1 - 3.5e-38 130.2 0.7 6.5e-34 116.5 0.0 3.4 4 0 0 4 4 4 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain F420_oxidored PF03807.17 CDL00936.1 - 6.5e-06 26.7 0.1 0.17 12.5 0.0 4.0 4 0 0 4 4 4 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 CDL00936.1 - 0.00014 21.8 0.0 0.00049 20.0 0.0 1.9 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 CDL00936.1 - 0.0031 17.4 0.8 0.0089 15.9 0.8 1.8 1 1 0 1 1 1 1 NAD(P)H-binding OTCace PF00185.24 CDL00936.1 - 0.0035 17.4 0.1 2.4 8.2 0.0 3.3 3 0 0 3 3 3 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain GFO_IDH_MocA PF01408.22 CDL00936.1 - 0.011 16.6 0.1 12 6.8 0.1 3.7 2 1 0 3 3 3 0 Oxidoreductase family, NAD-binding Rossmann fold ADH_zinc_N PF00107.26 CDL00936.1 - 0.014 15.4 2.7 0.45 10.5 0.1 3.6 3 1 1 4 4 4 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CDL00936.1 - 0.036 13.4 0.1 0.46 9.8 0.0 2.6 3 1 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CDL00936.1 - 0.037 13.3 0.1 0.069 12.4 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain AnmK PF03702.14 CDL00936.1 - 0.039 13.0 0.0 0.073 12.2 0.0 1.4 1 0 0 1 1 1 0 Anhydro-N-acetylmuramic acid kinase NAD_Gly3P_dh_N PF01210.23 CDL00936.1 - 0.041 13.9 0.1 0.69 9.9 0.0 2.8 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 CDL00936.1 - 0.064 13.4 1.1 0.61 10.2 0.1 2.9 3 1 0 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase potato_inhibit PF00280.18 CDL00936.1 - 0.074 13.7 0.1 0.26 12.0 0.1 2.0 1 0 0 1 1 1 0 Potato inhibitor I family ApbA PF02558.16 CDL00936.1 - 0.17 11.5 0.0 0.37 10.4 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 CDL00936.1 - 0.28 11.4 2.8 12 6.2 0.3 4.1 3 1 0 4 4 4 0 TrkA-N domain CheW PF01584.19 CDL00938.1 - 4.9e-24 84.5 0.2 6.1e-24 84.2 0.2 1.1 1 0 0 1 1 1 1 CheW-like domain Oxidored_q6 PF01058.22 CDL00938.1 - 0.0074 16.1 0.1 0.02 14.7 0.0 1.7 1 1 1 2 2 2 1 NADH ubiquinone oxidoreductase, 20 Kd subunit GGDEF PF00990.21 CDL00939.1 - 2.4e-44 150.9 0.1 3.9e-44 150.3 0.1 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain Response_reg PF00072.24 CDL00939.1 - 1.9e-40 137.5 0.0 6.4e-23 81.1 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain Hpt PF01627.23 CDL00939.1 - 6.3e-08 32.8 0.5 1.8e-07 31.3 0.5 1.9 1 0 0 1 1 1 1 Hpt domain GGDEF_2 PF17853.1 CDL00939.1 - 0.0016 18.6 0.1 0.0094 16.2 0.0 2.3 2 0 0 2 2 2 1 GGDEF-like domain Response_reg PF00072.24 CDL00940.1 - 6.3e-18 65.0 0.3 7e-18 64.8 0.3 1.0 1 0 0 1 1 1 1 Response regulator receiver domain RimK PF08443.11 CDL00940.1 - 0.012 15.3 0.3 0.018 14.6 0.3 1.2 1 0 0 1 1 1 0 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 CDL00940.1 - 0.13 12.3 0.1 0.22 11.6 0.1 1.3 1 1 0 1 1 1 0 ATP-grasp domain FleQ PF06490.11 CDL00940.1 - 0.16 12.3 0.0 0.19 12.1 0.0 1.2 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ Response_reg PF00072.24 CDL00941.1 - 3.1e-25 88.5 0.3 7.3e-25 87.3 0.3 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Hpt PF01627.23 CDL00941.1 - 1.2e-20 73.6 2.4 1.9e-20 72.9 0.5 2.4 3 0 0 3 3 3 1 Hpt domain HATPase_c PF02518.26 CDL00941.1 - 1.2e-16 61.1 0.0 2.8e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CheW PF01584.19 CDL00941.1 - 6.6e-15 55.0 1.6 2.1e-14 53.4 1.6 1.9 1 0 0 1 1 1 1 CheW-like domain H-kinase_dim PF02895.14 CDL00941.1 - 6e-11 42.6 1.9 1.1e-10 41.8 0.9 1.9 2 0 0 2 2 2 1 Signal transducing histidine kinase, homodimeric domain CAP_N PF01213.19 CDL00941.1 - 0.021 14.4 1.1 0.033 13.7 1.1 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF2680 PF10925.8 CDL00941.1 - 0.14 12.1 0.0 0.38 10.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) PRIMA1 PF16101.5 CDL00941.1 - 0.2 11.7 3.8 0.37 10.8 3.8 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CheR PF01739.18 CDL00942.1 - 9.6e-49 165.5 0.0 1.5e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain TPR_19 PF14559.6 CDL00942.1 - 1.4e-09 38.3 7.4 0.00028 21.3 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDL00942.1 - 1.2e-07 31.9 17.2 0.014 16.1 0.3 5.4 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDL00942.1 - 2.1e-07 30.5 5.9 0.031 14.4 0.4 4.6 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDL00942.1 - 9.4e-07 29.4 13.6 0.0022 18.6 1.1 3.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDL00942.1 - 2.5e-06 27.7 14.6 0.0042 17.3 1.5 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CDL00942.1 - 4.3e-06 26.3 3.0 4.3e-06 26.3 3.0 2.1 2 0 0 2 2 2 1 MalT-like TPR region TPR_1 PF00515.28 CDL00942.1 - 5.2e-06 26.0 0.1 0.32 10.9 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat CheR_N PF03705.15 CDL00942.1 - 6.6e-06 25.8 0.0 2.3e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 CheR methyltransferase, all-alpha domain TPR_6 PF13174.6 CDL00942.1 - 0.0003 21.2 8.9 0.0011 19.4 0.5 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDL00942.1 - 0.0017 18.6 1.3 0.78 10.0 0.0 2.8 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CDL00942.1 - 0.011 16.1 0.1 11 6.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDL00942.1 - 0.027 15.1 0.6 0.027 15.1 0.6 6.2 5 1 0 5 5 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDL00942.1 - 0.036 14.1 9.0 18 5.7 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Methyltransf_25 PF13649.6 CDL00942.1 - 0.045 14.5 0.3 1.8 9.3 0.3 2.7 1 1 0 1 1 1 0 Methyltransferase domain HrpB1_HrpK PF09613.10 CDL00942.1 - 0.079 12.6 1.1 0.19 11.3 0.7 1.8 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_8 PF13181.6 CDL00942.1 - 0.11 12.8 0.1 9.2 6.8 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DEC-1_N PF04625.13 CDL00942.1 - 1.3 7.9 6.9 1.9 7.4 6.9 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region TPR_10 PF13374.6 CDL00942.1 - 1.9 8.5 13.5 4.8 7.2 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat CheB_methylest PF01339.17 CDL00943.1 - 1.9e-57 193.7 0.7 4.6e-57 192.4 0.1 1.8 2 0 0 2 2 2 1 CheB methylesterase Response_reg PF00072.24 CDL00943.1 - 3.4e-22 78.7 0.0 6.1e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Inositol_P PF00459.25 CDL00943.1 - 0.19 11.2 1.3 11 5.4 0.1 2.1 2 0 0 2 2 2 0 Inositol monophosphatase family dCache_3 PF14827.6 CDL00944.1 - 4e-36 124.9 0.0 4e-36 124.9 0.0 2.2 3 0 0 3 3 3 1 Double sensory domain of two-component sensor kinase MCPsignal PF00015.21 CDL00944.1 - 9.2e-31 107.0 40.7 9.6e-31 106.9 18.3 3.8 2 1 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDL00944.1 - 7.5e-10 39.0 5.2 4.4e-09 36.6 0.8 4.4 5 0 0 5 5 4 1 HAMP domain dCache_1 PF02743.18 CDL00944.1 - 0.0043 16.9 0.0 0.83 9.4 0.0 3.1 2 1 0 2 2 2 1 Cache domain DUF948 PF06103.11 CDL00944.1 - 0.46 10.8 23.1 0.28 11.5 0.2 5.5 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 CDL00944.1 - 0.5 9.2 11.5 0.18 10.7 5.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein V_ATPase_I PF01496.19 CDL00944.1 - 0.62 7.9 6.7 1.1 7.0 6.7 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.12 CDL00944.1 - 1.6 8.7 23.7 7.5 6.6 8.5 3.9 2 2 2 4 4 4 0 Laminin Domain II ISG65-75 PF11727.8 CDL00944.1 - 1.6 7.9 13.8 0.54 9.4 6.1 2.5 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF3275 PF11679.8 CDL00944.1 - 1.8 8.5 4.8 4.4 7.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) PLU-1 PF08429.11 CDL00944.1 - 1.8 7.6 5.2 5.1 6.2 0.2 2.3 2 0 0 2 2 2 0 PLU-1-like protein DUF3080 PF11279.8 CDL00944.1 - 1.9 7.7 7.5 0.13 11.5 0.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3080) DUF3597 PF12200.8 CDL00944.1 - 1.9 9.0 7.5 0.32 11.5 2.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) Pex19 PF04614.12 CDL00944.1 - 2.2 8.0 12.0 0.065 13.0 4.4 2.2 3 0 0 3 3 3 0 Pex19 protein family Fez1 PF06818.15 CDL00944.1 - 4 7.8 11.4 1.4 9.3 2.7 2.5 1 1 1 2 2 2 0 Fez1 BRE1 PF08647.11 CDL00944.1 - 4.2 7.5 8.1 0.6 10.2 2.0 2.8 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase Dor1 PF04124.12 CDL00944.1 - 5.1 5.7 9.5 0.61 8.7 1.4 2.5 2 1 1 3 3 3 0 Dor1-like family Mod_r PF07200.13 CDL00944.1 - 6.2 6.9 7.8 9.1 6.4 0.2 3.2 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Synuclein PF01387.17 CDL00945.1 - 0.085 13.1 1.7 0.24 11.6 1.7 1.7 1 0 0 1 1 1 0 Synuclein CHASE2 PF05226.11 CDL00946.1 - 4.8e-32 111.6 0.3 9.4e-32 110.7 0.3 1.4 1 0 0 1 1 1 1 CHASE2 domain Guanylate_cyc PF00211.20 CDL00946.1 - 1.6e-31 109.4 0.0 3e-31 108.5 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain TPR_2 PF07719.17 CDL00946.1 - 0.11 12.7 1.4 0.28 11.4 1.4 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat CHAT PF12770.7 CDL00947.1 - 1.1e-71 241.7 0.2 3.4e-71 240.0 0.0 2.0 2 1 0 2 2 2 1 CHAT domain TPR_12 PF13424.6 CDL00947.1 - 7e-69 228.1 43.7 1.6e-16 60.3 0.9 10.6 5 3 7 12 12 12 12 Tetratricopeptide repeat TPR_10 PF13374.6 CDL00947.1 - 3.1e-55 182.6 39.0 4.5e-08 32.7 0.1 13.8 14 0 0 14 14 14 8 Tetratricopeptide repeat TPR_7 PF13176.6 CDL00947.1 - 1.6e-22 77.8 22.0 5.8e-05 22.8 0.1 11.7 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_2 PF07719.17 CDL00947.1 - 2.1e-16 58.6 37.3 0.017 15.2 0.1 13.4 14 0 0 14 14 14 6 Tetratricopeptide repeat TPR_MalT PF17874.1 CDL00947.1 - 5.2e-14 52.4 38.9 1.6e-07 31.0 1.2 5.1 2 1 0 5 5 5 4 MalT-like TPR region TPR_1 PF00515.28 CDL00947.1 - 7.9e-14 50.8 31.3 0.00059 19.6 0.1 10.2 12 0 0 12 12 12 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDL00947.1 - 8.3e-11 41.2 24.9 0.36 11.2 0.1 10.9 12 0 0 12 12 11 3 Tetratricopeptide repeat TPR_4 PF07721.14 CDL00947.1 - 1.2e-09 37.8 60.1 0.26 12.0 3.9 14.3 15 0 0 15 15 14 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDL00947.1 - 1.7e-06 28.6 83.1 0.0021 18.7 1.0 12.7 8 5 4 12 12 12 7 Tetratricopeptide repeat TPR_19 PF14559.6 CDL00947.1 - 8.6e-06 26.2 62.2 0.025 15.1 4.5 10.7 7 3 5 12 12 12 4 Tetratricopeptide repeat TPR_14 PF13428.6 CDL00947.1 - 7.8e-05 23.2 66.5 0.27 12.2 0.3 14.5 11 4 4 15 15 15 3 Tetratricopeptide repeat TPR_17 PF13431.6 CDL00947.1 - 0.01 16.2 17.4 26 5.5 0.0 8.9 10 0 0 10 10 10 0 Tetratricopeptide repeat USP8_dimer PF08969.11 CDL00947.1 - 0.022 14.9 0.0 0.066 13.4 0.0 1.8 1 0 0 1 1 1 0 USP8 dimerisation domain cNMP_binding PF00027.29 CDL00948.1 - 4.2e-20 71.6 0.1 2.9e-10 40.1 0.0 3.8 4 0 0 4 4 4 2 Cyclic nucleotide-binding domain Hemerythrin PF01814.23 CDL00948.1 - 1.7e-13 51.3 1.0 3e-13 50.5 1.0 1.5 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Lactamase_B_2 PF12706.7 CDL00948.1 - 8e-10 38.6 0.2 1.6e-09 37.6 0.2 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDL00948.1 - 5.8e-07 29.7 1.0 1.4e-06 28.4 0.3 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily TP_methylase PF00590.20 CDL00950.1 - 1.2e-50 172.5 0.0 1.4e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases CbiX PF01903.17 CDL00951.1 - 4.9e-28 97.6 0.1 5.1e-13 49.3 0.1 2.1 2 0 0 2 2 2 2 CbiX CbiK PF06180.11 CDL00951.1 - 0.002 17.5 0.0 0.84 8.9 0.0 2.3 3 0 0 3 3 3 2 Cobalt chelatase (CbiK) GGACT PF06094.12 CDL00952.1 - 6.5e-16 59.0 0.0 8.3e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like PGM_PMM_I PF02878.16 CDL00953.1 - 3.8e-31 107.6 0.0 7.2e-31 106.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 CDL00953.1 - 7.8e-24 84.3 0.1 1.5e-23 83.3 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 CDL00953.1 - 4.9e-21 75.0 0.0 8.6e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 CDL00953.1 - 5.2e-12 45.8 0.2 1.3e-11 44.5 0.2 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DUF2218 PF09981.9 CDL00953.1 - 0.057 13.8 0.0 0.31 11.5 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2218) SBP_bac_3 PF00497.20 CDL00954.1 - 1.4e-17 63.9 0.0 2.6e-17 63.0 0.0 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 LysR_substrate PF03466.20 CDL00954.1 - 0.0015 18.0 0.0 0.0068 15.8 0.0 2.1 1 1 0 1 1 1 1 LysR substrate binding domain GcpE PF04551.14 CDL00955.1 - 1.5e-129 432.1 0.2 1.8e-129 431.9 0.2 1.0 1 0 0 1 1 1 1 GcpE protein MR_MLE_C PF13378.6 CDL00955.1 - 0.014 14.9 1.0 0.035 13.7 1.0 1.7 1 1 1 2 2 2 0 Enolase C-terminal domain-like AP_endonuc_2 PF01261.24 CDL00955.1 - 0.02 14.3 0.0 11 5.4 0.0 3.0 3 0 0 3 3 3 0 Xylose isomerase-like TIM barrel Methyltransf_25 PF13649.6 CDL00956.1 - 2.6e-10 40.9 0.0 8.6e-10 39.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CDL00956.1 - 1.6e-08 34.3 0.0 2e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDL00956.1 - 2.2e-08 34.0 0.0 3.3e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL00956.1 - 6.2e-07 30.1 0.0 1.3e-06 29.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL00956.1 - 1.9e-06 28.4 0.0 6.6e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL00956.1 - 0.00026 20.9 0.0 0.00039 20.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CDL00956.1 - 0.0014 18.0 0.0 0.0018 17.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain PrmA PF06325.13 CDL00956.1 - 0.0057 16.1 0.0 0.0074 15.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 CDL00956.1 - 0.07 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.20 CDL00956.1 - 0.11 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase tRNA-synt_His PF13393.6 CDL00958.1 - 1.4e-48 165.8 0.0 1.8e-48 165.4 0.0 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 CDL00958.1 - 3.1e-20 72.9 0.0 5.2e-20 72.2 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CDL00958.1 - 8.3e-14 51.5 0.0 2.1e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2d PF01409.20 CDL00958.1 - 2e-05 24.2 0.0 0.00073 19.1 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) GlutR_N PF05201.15 CDL00959.1 - 2.4e-37 127.9 0.0 4.7e-37 127.0 0.0 1.5 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.20 CDL00959.1 - 1e-25 90.4 0.1 1.6e-25 89.8 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.20 CDL00959.1 - 1e-08 35.5 0.1 1.6e-07 31.6 0.0 2.6 2 1 0 2 2 2 1 Glutamyl-tRNAGlu reductase, dimerisation domain F420_oxidored PF03807.17 CDL00959.1 - 0.00022 21.7 0.4 0.00083 19.9 0.4 2.0 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CDL00959.1 - 0.0045 16.4 0.1 0.008 15.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 CDL00959.1 - 0.0078 16.1 1.9 0.018 14.9 1.9 1.7 1 0 0 1 1 1 1 NAD(P)H-binding PCRF PF03462.18 CDL00960.1 - 6.1e-66 222.0 0.1 6.1e-66 222.0 0.1 1.7 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 CDL00960.1 - 1.1e-40 138.2 1.7 1.9e-40 137.4 1.7 1.4 1 0 0 1 1 1 1 RF-1 domain MIR PF02815.19 CDL00960.1 - 0.042 13.7 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 MIR domain PrmC_N PF17827.1 CDL00961.1 - 5e-18 65.4 1.4 1.1e-17 64.3 1.4 1.6 1 0 0 1 1 1 1 PrmC N-terminal domain Methyltransf_31 PF13847.6 CDL00961.1 - 7.3e-15 55.1 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDL00961.1 - 5.9e-13 48.7 0.0 9.3e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDL00961.1 - 2e-10 41.3 0.2 1.9e-09 38.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 CDL00961.1 - 6.3e-08 32.4 0.0 9.5e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 CDL00961.1 - 4.1e-06 27.4 0.3 4.8e-05 24.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 CDL00961.1 - 1.5e-05 24.8 0.0 2.5e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 CDL00961.1 - 0.00018 22.1 0.2 0.00075 20.1 0.0 2.1 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL00961.1 - 0.0022 17.9 0.1 0.0082 16.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 CDL00961.1 - 0.0059 16.6 0.0 0.0097 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_20 PF12147.8 CDL00961.1 - 0.014 14.6 0.0 0.031 13.4 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_18 PF12847.7 CDL00961.1 - 0.021 14.8 0.0 0.031 14.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PDDEXK_1 PF12705.7 CDL00961.1 - 0.085 12.8 0.0 0.1 12.5 0.0 1.1 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Cons_hypoth95 PF03602.15 CDL00961.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Eco57I PF07669.11 CDL00961.1 - 0.25 11.9 0.1 0.45 11.0 0.1 1.3 1 0 0 1 1 1 0 Eco57I restriction-modification methylase DUF4167 PF13763.6 CDL00962.1 - 7.5e-27 93.3 1.8 7.5e-27 93.3 1.8 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4167) CDC45 PF02724.14 CDL00962.1 - 1.1 7.4 10.1 1.4 7.1 10.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1771 PF08590.10 CDL00962.1 - 4.9 7.6 9.1 0.27 11.6 3.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1771) eIF-3_zeta PF05091.12 CDL00962.1 - 7.5 5.4 8.7 9.4 5.1 8.7 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AAA_2 PF07724.14 CDL00963.1 - 5.5e-58 195.9 0.0 3.6e-56 190.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CDL00963.1 - 1.9e-36 124.1 1.1 1.9e-36 124.1 1.1 3.5 3 0 0 3 3 3 1 AAA lid domain Clp_N PF02861.20 CDL00963.1 - 6.7e-25 87.0 7.4 4.8e-13 49.0 2.7 2.8 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component ClpB_D2-small PF10431.9 CDL00963.1 - 6.6e-24 83.8 0.0 2.5e-23 81.9 0.0 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CDL00963.1 - 3.4e-22 79.3 0.0 1.9e-11 44.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDL00963.1 - 3.1e-18 66.1 0.1 1.7e-13 50.8 0.0 3.5 2 1 1 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDL00963.1 - 1.2e-09 38.7 10.7 0.00025 21.4 0.1 5.2 4 3 1 5 5 5 2 AAA ATPase domain AAA_22 PF13401.6 CDL00963.1 - 9.9e-09 35.6 1.8 0.0078 16.5 0.0 4.8 3 2 0 3 3 3 2 AAA domain Sigma54_activat PF00158.26 CDL00963.1 - 3.2e-07 30.2 0.1 0.00015 21.5 0.0 2.9 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 CDL00963.1 - 2.2e-06 27.3 0.0 0.0098 15.4 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 CDL00963.1 - 4.2e-06 26.6 0.0 0.089 12.5 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein TniB PF05621.11 CDL00963.1 - 1.8e-05 24.2 0.0 0.011 15.2 0.0 3.3 2 1 0 2 2 2 1 Bacterial TniB protein AAA_18 PF13238.6 CDL00963.1 - 0.0001 22.8 0.1 0.35 11.4 0.0 3.3 3 0 0 3 3 2 1 AAA domain RuvB_N PF05496.12 CDL00963.1 - 0.00013 21.8 0.8 2.2 8.0 0.4 3.9 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 CDL00963.1 - 0.00018 21.8 1.4 0.93 9.7 0.0 4.0 3 2 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 CDL00963.1 - 0.00024 20.6 0.1 0.93 8.8 0.0 3.2 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 CDL00963.1 - 0.00028 20.9 0.9 4.3 7.2 0.2 3.9 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 CDL00963.1 - 0.00031 20.8 0.0 0.4 10.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CDL00963.1 - 0.00065 19.6 0.0 0.97 9.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 CDL00963.1 - 0.00076 20.0 6.1 1.4 9.3 0.0 3.2 2 1 0 2 2 2 1 AAA domain Roc PF08477.13 CDL00963.1 - 0.001 19.3 0.0 1.4 9.2 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 CDL00963.1 - 0.0017 18.1 0.0 1.6 8.4 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_3 PF07726.11 CDL00963.1 - 0.004 17.0 0.1 0.7 9.8 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CDL00963.1 - 0.0046 17.3 0.0 1.8 9.0 0.0 2.5 2 0 0 2 2 2 1 RNA helicase TsaE PF02367.17 CDL00963.1 - 0.0051 16.8 0.0 2.4 8.2 0.0 2.7 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 CDL00963.1 - 0.011 15.5 0.0 7 6.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain NACHT PF05729.12 CDL00963.1 - 0.016 15.1 0.0 1.3 8.9 0.0 2.7 2 0 0 2 2 2 0 NACHT domain ABC_tran PF00005.27 CDL00963.1 - 0.019 15.5 0.0 2.7 8.5 0.0 2.8 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.6 CDL00963.1 - 0.02 15.2 0.2 2.8 8.3 0.1 3.3 3 1 0 3 3 2 0 AAA domain DNA_pol3_delta2 PF13177.6 CDL00963.1 - 0.021 14.6 0.0 2.3 8.0 0.0 2.4 2 0 0 2 2 2 0 DNA polymerase III, delta subunit Bac_DnaA PF00308.18 CDL00963.1 - 0.026 14.4 0.0 6.9 6.4 0.0 3.1 3 0 0 3 3 3 0 Bacterial dnaA protein T2SSE PF00437.20 CDL00963.1 - 0.026 13.6 0.0 0.061 12.4 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF4472 PF14739.6 CDL00963.1 - 0.031 15.0 5.6 0.11 13.2 5.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) AAA_25 PF13481.6 CDL00963.1 - 0.034 13.7 0.0 1.3 8.5 0.0 3.0 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CDL00963.1 - 0.042 13.0 0.1 5.7 6.0 0.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 CDL00963.1 - 0.054 13.7 0.1 13 5.9 0.0 3.1 3 0 0 3 3 2 0 AAA domain AAA_assoc_2 PF16193.5 CDL00963.1 - 0.19 12.1 1.2 1.5 9.2 0.1 2.8 2 0 0 2 2 2 0 AAA C-terminal domain DUF1640 PF07798.11 CDL00963.1 - 0.8 9.7 3.8 1.6 8.7 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Peptidase_M23 PF01551.22 CDL00964.1 - 5.8e-31 106.6 3.5 7.7e-31 106.2 1.4 2.3 2 0 0 2 2 2 1 Peptidase family M23 Big_8 PF17961.1 CDL00964.1 - 0.023 14.8 0.1 0.095 12.9 0.1 2.0 2 0 0 2 2 2 0 Bacterial Ig domain HTH_Tnp_1 PF01527.20 CDL00967.1 - 5e-16 58.8 0.6 6.5e-16 58.4 0.6 1.2 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDL00967.1 - 0.0025 17.6 0.9 0.0052 16.5 0.9 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 CDL00967.1 - 0.0031 17.6 0.9 0.0071 16.4 0.9 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 CDL00967.1 - 0.07 12.9 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_17 PF12728.7 CDL00967.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain TnpB_IS66 PF05717.13 CDL00968.1 - 5.8e-36 122.4 0.0 6.6e-36 122.3 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein DDE_Tnp_IS66 PF03050.14 CDL00969.1 - 4.2e-89 298.8 1.0 2.1e-88 296.5 0.0 1.9 2 0 0 2 2 2 1 Transposase IS66 family LZ_Tnp_IS66 PF13007.7 CDL00969.1 - 1.2e-16 61.2 4.1 1.2e-16 61.2 4.1 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDL00969.1 - 4.2e-15 55.9 6.3 8.8e-15 54.8 6.3 1.6 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Rab5-bind PF09311.11 CDL00969.1 - 0.0051 16.2 0.4 0.009 15.4 0.4 1.4 1 0 0 1 1 1 1 Rabaptin-like protein BLOC1_2 PF10046.9 CDL00969.1 - 0.082 13.2 0.4 0.19 12.1 0.4 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TackOD1 PF18551.1 CDL00969.1 - 0.15 11.7 0.1 0.32 10.7 0.1 1.4 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 ABC_tran_Xtn PF12848.7 CDL00969.1 - 0.77 9.8 5.3 2.3 8.3 0.9 2.3 2 0 0 2 2 2 0 ABC transporter ZapB PF06005.12 CDL00969.1 - 1.6 9.2 5.3 1.3 9.5 2.9 1.9 2 0 0 2 2 2 0 Cell division protein ZapB DDE_Tnp_IS66_C PF13817.6 CDL00970.1 - 1.3e-19 70.1 0.2 1.7e-19 69.8 0.2 1.1 1 0 0 1 1 1 1 IS66 C-terminal element Bclx_interact PF08945.10 CDL00970.1 - 0.0057 16.4 0.1 0.0097 15.7 0.1 1.3 1 0 0 1 1 1 1 Bcl-x interacting, BH3 domain STAT2_C PF12188.8 CDL00971.1 - 0.071 13.0 0.1 0.081 12.9 0.1 1.2 1 1 0 1 1 1 0 Signal transducer and activator of transcription 2 C terminal Response_reg PF00072.24 CDL00973.1 - 1.9e-18 66.7 0.0 3.4e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Hemerythrin PF01814.23 CDL00973.1 - 1.3e-10 42.0 3.3 1.8e-10 41.5 3.3 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Glyco_tranf_2_3 PF13641.6 CDL00973.1 - 0.12 12.3 0.2 0.12 12.3 0.2 1.7 2 0 0 2 2 2 0 Glycosyltransferase like family 2 PAS_3 PF08447.12 CDL00975.1 - 2.9e-13 49.9 0.0 4.2e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CDL00975.1 - 9.2e-12 45.0 0.0 1.5e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDL00975.1 - 2.9e-11 43.6 0.0 4.2e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDL00975.1 - 1.6e-06 28.3 0.0 3.4e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDL00975.1 - 2.5e-06 27.3 0.0 5e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 PAS domain MCPsignal PF00015.21 CDL00976.1 - 1.1e-30 106.8 42.9 2.8e-30 105.4 26.9 2.8 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain CZB PF13682.6 CDL00976.1 - 1.9e-10 41.0 0.0 4.7e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Chemoreceptor zinc-binding domain PilZ PF07238.14 CDL00976.1 - 8.7e-09 35.6 0.0 3.7e-07 30.4 0.0 2.7 2 1 0 2 2 2 1 PilZ domain IFT57 PF10498.9 CDL00976.1 - 0.0058 15.6 8.7 0.053 12.5 0.0 2.6 3 0 0 3 3 3 2 Intra-flagellar transport protein 57 DUF1664 PF07889.12 CDL00976.1 - 0.021 14.9 15.4 1.6 8.7 1.0 4.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) HAMP PF00672.25 CDL00976.1 - 0.12 12.8 0.2 0.12 12.8 0.2 3.2 3 0 0 3 3 2 0 HAMP domain UPF0242 PF06785.11 CDL00976.1 - 0.12 12.4 3.1 0.75 9.9 0.1 2.9 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 CDL00976.1 - 0.16 12.1 11.3 0.87 9.8 0.1 3.6 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family EzrA PF06160.12 CDL00976.1 - 0.36 8.9 12.5 0.022 13.0 3.0 2.7 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA TMPIT PF07851.13 CDL00976.1 - 0.63 9.2 5.4 5.5 6.2 1.2 2.6 2 1 0 2 2 2 0 TMPIT-like protein SKA1 PF07160.12 CDL00976.1 - 0.71 9.7 7.2 0.94 9.3 1.2 3.0 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 DUF948 PF06103.11 CDL00976.1 - 1 9.7 30.2 1.8 8.9 3.6 6.1 3 1 3 6 6 6 0 Bacterial protein of unknown function (DUF948) LacI PF00356.21 CDL00976.1 - 1.3 8.9 6.7 0.52 10.1 0.8 3.4 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family Laminin_II PF06009.12 CDL00976.1 - 1.7 8.6 29.1 1.3 9.1 1.5 5.1 2 1 3 5 5 5 0 Laminin Domain II Glypican PF01153.19 CDL00976.1 - 2 7.1 10.5 0.77 8.5 4.1 2.1 2 0 0 2 2 2 0 Glypican AATF-Che1 PF13339.6 CDL00976.1 - 2.2 9.0 10.1 4.2 8.0 0.3 2.9 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor CorA PF01544.18 CDL00976.1 - 2.8 7.2 11.4 0.91 8.8 0.3 3.7 3 1 1 4 4 4 0 CorA-like Mg2+ transporter protein DUF745 PF05335.13 CDL00976.1 - 3.1 7.5 41.0 8.5 6.0 15.7 3.9 2 1 1 3 3 3 0 Protein of unknown function (DUF745) MIP-T3_C PF17749.1 CDL00976.1 - 4.1 7.4 11.5 17 5.3 5.5 3.6 1 1 2 3 3 3 0 Microtubule-binding protein MIP-T3 C-terminal region Syntaxin-6_N PF09177.11 CDL00976.1 - 5.3 7.7 14.7 19 5.9 4.4 4.5 3 1 1 4 4 3 0 Syntaxin 6, N-terminal V_ATPase_I PF01496.19 CDL00976.1 - 9 4.1 7.5 2.4 6.0 1.7 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Phage_integrase PF00589.22 CDL00977.1 - 7e-05 22.7 0.0 0.00012 21.9 0.0 1.4 1 1 0 1 1 1 1 Phage integrase family Arm-DNA-bind_3 PF13356.6 CDL00977.1 - 9.3e-05 22.7 0.0 0.00014 22.2 0.0 1.3 1 0 0 1 1 1 1 Arm DNA-binding domain ResIII PF04851.15 CDL00978.1 - 7.8e-17 61.8 0.0 1.3e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDL00978.1 - 5.3e-07 29.6 0.1 1.1e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDL00978.1 - 0.00046 20.5 0.0 0.00095 19.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEPN PF05168.14 CDL00979.1 - 5.4e-15 55.6 0.0 6.3e-15 55.4 0.0 1.0 1 0 0 1 1 1 1 HEPN domain NTP_transf_2 PF01909.23 CDL00980.1 - 3.1e-08 33.8 0.0 4.9e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 CDL00980.1 - 4.2e-07 30.0 0.0 6.8e-07 29.3 0.0 1.4 1 1 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase ABM PF03992.16 CDL00980.1 - 0.079 13.1 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase Zn-ribbon_8 PF09723.10 CDL00981.1 - 0.026 14.6 3.4 0.052 13.7 3.4 1.5 1 0 0 1 1 1 0 Zinc ribbon domain BAR_3_WASP_bdg PF10456.9 CDL00981.1 - 0.053 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 WASP-binding domain of Sorting nexin protein NADH_4Fe-4S PF10589.9 CDL00981.1 - 0.38 10.9 2.1 0.98 9.5 2.1 1.7 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region zf-Mss51 PF13824.6 CDL00981.1 - 2.5 8.3 6.8 4.4 7.5 2.0 2.6 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-ACC PF17848.1 CDL00981.1 - 5.5 7.2 6.4 2.5 8.2 0.3 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain YAcAr PF10686.9 CDL00982.1 - 0.02 14.8 0.2 0.042 13.8 0.2 1.5 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family Peptidase_M78 PF06114.13 CDL00983.1 - 5.6e-17 61.8 0.2 2.2e-16 59.9 0.1 2.0 2 1 0 2 2 2 1 IrrE N-terminal-like domain HTH_31 PF13560.6 CDL00983.1 - 2e-12 47.2 7.0 1.4e-11 44.5 1.7 3.5 4 0 0 4 4 4 1 Helix-turn-helix domain HTH_3 PF01381.22 CDL00983.1 - 2.3e-11 43.5 0.0 2.5e-09 37.1 0.0 3.1 3 0 0 3 3 3 1 Helix-turn-helix HTH_19 PF12844.7 CDL00983.1 - 3e-11 43.2 0.2 4.8e-09 36.1 0.0 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_25 PF13413.6 CDL00983.1 - 1.6e-06 27.8 0.2 6.4e-05 22.7 0.1 2.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_IclR PF09339.10 CDL00983.1 - 0.0011 18.7 0.7 0.4 10.5 0.2 2.9 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_37 PF13744.6 CDL00983.1 - 0.0012 18.7 0.5 0.021 14.7 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDL00983.1 - 0.0013 18.4 1.5 0.14 12.0 0.1 3.3 3 0 0 3 3 3 1 Homeodomain-like domain HTH_26 PF13443.6 CDL00983.1 - 0.0033 17.8 0.1 0.49 10.9 0.0 2.5 2 0 0 2 2 2 1 Cro/C1-type HTH DNA-binding domain MarR_2 PF12802.7 CDL00983.1 - 0.015 15.2 1.0 4.1 7.4 0.1 3.7 3 0 0 3 3 3 0 MarR family UPF0175 PF03683.13 CDL00983.1 - 0.033 13.9 0.1 0.12 12.1 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0175) IF2_N PF04760.15 CDL00983.1 - 0.038 13.8 0.0 8.1 6.4 0.0 3.0 3 0 0 3 3 3 0 Translation initiation factor IF-2, N-terminal region HTH_24 PF13412.6 CDL00983.1 - 0.059 12.9 0.2 0.86 9.2 0.0 2.6 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding DDE_3 PF13358.6 CDL00986.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL00986.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDL00987.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL00987.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL00987.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL00987.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL00987.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL00987.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain GntP_permease PF02447.16 CDL00988.1 - 1.2e-24 86.8 36.7 1.3e-23 83.4 36.7 2.3 1 1 0 1 1 1 1 GntP family permease Cellulase PF00150.18 CDL00989.1 - 4.2e-27 95.3 0.0 6.3e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) HTH_Tnp_1 PF01527.20 CDL00991.1 - 2.7e-23 82.1 0.3 3.9e-23 81.6 0.3 1.3 1 0 0 1 1 1 1 Transposase HTH_23 PF13384.6 CDL00991.1 - 4.3e-05 23.2 0.4 0.00017 21.3 0.0 2.2 1 1 2 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.6 CDL00991.1 - 6.5e-05 23.0 0.4 0.00017 21.7 0.0 1.9 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_1_2 PF13022.6 CDL00991.1 - 0.00035 20.7 0.8 0.0024 18.0 0.5 1.9 1 1 1 2 2 2 1 Helix-turn-helix of insertion element transposase HTH_7 PF02796.15 CDL00991.1 - 0.0072 16.4 0.4 0.066 13.3 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_29 PF13551.6 CDL00991.1 - 0.0077 16.2 0.1 0.015 15.3 0.1 1.7 1 1 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_IS630 PF01710.16 CDL00991.1 - 0.069 13.2 0.2 0.11 12.6 0.2 1.3 1 1 0 1 1 1 0 Transposase Diphthami_syn_2 PF01902.17 CDL00991.1 - 0.092 12.2 0.2 0.26 10.7 0.2 1.6 1 1 0 1 1 1 0 Diphthamide synthase rve_3 PF13683.6 CDL00992.1 - 7.1e-33 112.2 1.4 1.7e-32 111.0 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain rve PF00665.26 CDL00992.1 - 8.9e-25 87.2 0.0 1.6e-24 86.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain HTH_21 PF13276.6 CDL00992.1 - 2.1e-07 31.0 7.9 4.1e-07 30.0 7.9 1.5 1 0 0 1 1 1 1 HTH-like domain rve_2 PF13333.6 CDL00992.1 - 3.4e-06 27.1 0.0 9e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CDL00992.1 - 0.014 15.6 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 DDE domain T4SS-DNA_transf PF02534.14 CDL00995.1 - 2.9e-47 161.5 0.0 2.5e-44 151.9 0.0 2.0 1 1 1 2 2 2 2 Type IV secretory system Conjugative DNA transfer TraG-D_C PF12696.7 CDL00995.1 - 8.5e-14 51.6 0.0 1.4e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 TraM recognition site of TraD and TraG TrwB_AAD_bind PF10412.9 CDL00995.1 - 5.2e-12 45.4 0.0 9.9e-12 44.5 0.0 1.4 1 1 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain DEAD PF00270.29 CDL00995.1 - 0.02 14.6 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase NYN PF01936.18 CDL00996.1 - 2.1e-12 47.8 0.3 9.1e-12 45.7 0.3 1.9 1 1 0 1 1 1 1 NYN domain T4SS-DNA_transf PF02534.14 CDL00997.1 - 1.1e-52 179.4 0.0 8e-25 87.6 0.0 3.0 2 1 1 3 3 3 3 Type IV secretory system Conjugative DNA transfer TraG-D_C PF12696.7 CDL00997.1 - 1e-20 74.0 0.0 1.9e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 TraM recognition site of TraD and TraG TrwB_AAD_bind PF10412.9 CDL00997.1 - 5e-16 58.6 0.0 7.9e-11 41.5 0.0 2.5 2 1 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain AAA_10 PF12846.7 CDL00997.1 - 0.0023 16.9 0.0 0.012 14.5 0.0 1.9 2 0 0 2 2 2 1 AAA-like domain CARD PF00619.21 CDL00998.1 - 0.076 13.1 0.0 20 5.3 0.0 2.8 2 0 0 2 2 2 0 Caspase recruitment domain LepB_GAP_N PF18172.1 CDL00998.1 - 0.14 12.0 0.1 0.46 10.4 0.0 1.9 2 0 0 2 2 2 0 LepB GAP domain N-terminal subdomain APG17 PF04108.12 CDL00999.1 - 0.012 14.8 0.2 2.4 7.2 0.0 2.9 3 0 0 3 3 3 0 Autophagy protein Apg17 DUF2884 PF11101.8 CDL00999.1 - 0.048 13.2 0.4 0.56 9.7 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) DDE_Tnp_IS66 PF03050.14 CDL01001.1 - 2.9e-89 299.3 0.4 4.9e-89 298.6 0.0 1.6 2 0 0 2 2 2 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDL01001.1 - 2.9e-18 65.8 0.0 1e-17 64.0 0.0 2.0 1 0 0 1 1 1 1 IS66 C-terminal element LZ_Tnp_IS66 PF13007.7 CDL01001.1 - 3e-16 59.9 4.3 3e-16 59.9 4.3 2.2 2 0 0 2 2 2 1 Transposase C of IS166 homeodomain zf-IS66 PF13005.7 CDL01001.1 - 1.5e-15 57.3 4.6 2.9e-15 56.4 4.6 1.5 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 Spc29 PF17082.5 CDL01001.1 - 0.18 11.6 0.1 0.31 10.9 0.1 1.3 1 0 0 1 1 1 0 Spindle Pole Component 29 SlyX PF04102.12 CDL01001.1 - 1.1 10.0 3.9 11 6.8 2.2 2.9 2 1 1 3 3 3 0 SlyX TnpB_IS66 PF05717.13 CDL01002.1 - 9.3e-38 128.2 0.0 1e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 IS66 Orf2 like protein Phage_integrase PF00589.22 CDL01004.1 - 1.7e-39 135.3 0.3 2.5e-39 134.8 0.3 1.2 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_4 PF13495.6 CDL01004.1 - 1.3e-15 57.6 0.0 3.8e-15 56.1 0.0 1.8 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_1 PF02899.17 CDL01004.1 - 1.7e-10 41.0 0.3 8.6e-10 38.8 0.1 2.3 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_integr_3 PF16795.5 CDL01004.1 - 0.081 12.8 0.1 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 Archaeal phage integrase Phosphonate-bd PF12974.7 CDL01008.1 - 6.7e-44 150.3 0.0 7.7e-44 150.1 0.0 1.0 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein HATPase_c PF02518.26 CDL01009.1 - 2.2e-24 86.1 0.0 4.9e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 CDL01009.1 - 7e-22 77.6 0.0 4.9e-17 62.1 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 CDL01009.1 - 1.6e-20 73.2 0.0 7.8e-15 54.9 0.0 2.8 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 CDL01009.1 - 4.4e-16 59.1 0.0 6.7e-11 42.4 0.0 3.2 3 0 0 3 3 3 2 PAS fold PAS_3 PF08447.12 CDL01009.1 - 1.4e-13 50.9 0.1 1e-11 45.0 0.0 3.4 4 0 0 4 4 4 1 PAS fold HAMP PF00672.25 CDL01009.1 - 8.1e-12 45.3 1.0 5.2e-11 42.7 0.3 2.7 2 0 0 2 2 2 1 HAMP domain HisKA PF00512.25 CDL01009.1 - 2.4e-09 37.1 0.3 1.4e-08 34.7 0.0 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 CDL01009.1 - 7e-08 32.9 0.3 9.7e-07 29.2 0.1 3.0 4 0 0 4 4 4 1 GAF domain PAS_8 PF13188.7 CDL01009.1 - 5.7e-07 29.4 0.0 2e-05 24.5 0.0 2.7 2 0 0 2 2 2 1 PAS domain GAF PF01590.26 CDL01009.1 - 5.7e-07 30.2 0.0 1.2e-06 29.2 0.0 1.6 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 CDL01009.1 - 0.00018 21.8 0.0 0.00039 20.8 0.0 1.6 1 0 0 1 1 1 1 GAF domain HATPase_c_5 PF14501.6 CDL01009.1 - 0.0036 17.2 0.0 0.0086 16.0 0.0 1.6 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 CDL01009.1 - 0.06 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MlaD PF02470.20 CDL01009.1 - 0.12 12.7 0.1 7.5 6.9 0.0 3.1 3 1 0 3 3 3 0 MlaD protein Hemerythrin PF01814.23 CDL01010.1 - 5.1e-07 30.4 1.0 5.1e-07 30.4 1.0 2.3 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain DDE_Tnp_IS1595 PF12762.7 CDL01011.1 - 1.4e-24 86.8 0.0 2.5e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 ISXO2-like transposase domain HATPase_c PF02518.26 CDL01012.1 - 5.3e-22 78.4 0.0 7.6e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CDL01012.1 - 3.4e-06 26.9 0.0 5e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 CDL01012.1 - 0.00056 19.7 0.0 0.00085 19.2 0.0 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CDL01012.1 - 0.0059 16.6 0.0 0.0078 16.2 0.0 1.4 1 1 0 1 1 1 1 Histidine kinase-like ATPase domain VHL PF01847.16 CDL01013.1 - 5.1e-11 42.3 0.0 7.4e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 VHL beta domain TMEM43 PF07787.12 CDL01014.1 - 3.1e-71 239.7 0.0 4e-71 239.3 0.0 1.1 1 0 0 1 1 1 1 Transmembrane protein 43 DUF2530 PF10745.9 CDL01014.1 - 0.6 10.4 15.2 0.16 12.2 7.9 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2530) Phage_holin_2_4 PF16082.5 CDL01014.1 - 1 9.2 5.5 0.48 10.2 2.0 2.3 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like NEMP PF10225.9 CDL01014.1 - 5.8 6.5 8.2 0.38 10.4 0.6 2.1 1 1 1 2 2 2 0 NEMP family DUF3472 PF11958.8 CDL01015.1 - 0.00029 21.4 0.0 0.00039 20.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3472) sCache_2 PF17200.4 CDL01016.1 - 0.064 13.1 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Single Cache domain 2 PEP-utilizers_C PF02896.18 CDL01021.1 - 1.4e-85 287.0 0.0 2e-85 286.5 0.0 1.2 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PEP-utilisers_N PF05524.13 CDL01021.1 - 7.4e-23 80.9 0.0 1.7e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 PEP-utilising enzyme, N-terminal PEP-utilizers PF00391.23 CDL01021.1 - 7.1e-17 60.9 0.0 2e-16 59.5 0.0 1.8 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain GAF_2 PF13185.6 CDL01021.1 - 1.8e-15 57.5 0.4 7.6e-15 55.4 0.2 2.2 2 0 0 2 2 2 1 GAF domain GAF PF01590.26 CDL01021.1 - 8.7e-12 45.8 0.4 3.3e-11 43.9 0.1 2.1 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 CDL01021.1 - 0.0032 17.8 0.0 0.0093 16.3 0.0 1.9 1 0 0 1 1 1 1 GAF domain SpoVT_C PF15714.5 CDL01021.1 - 0.054 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor NMO PF03060.15 CDL01022.1 - 1.4e-50 172.6 5.9 1e-32 113.9 2.7 2.0 1 1 1 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.25 CDL01022.1 - 3e-08 33.0 0.2 2e-07 30.3 0.2 1.9 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 CDL01022.1 - 8.8e-07 28.5 3.9 1.4e-06 27.8 3.9 1.3 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG FMN_dh PF01070.18 CDL01022.1 - 4.9e-05 22.5 2.3 4.9e-05 22.5 2.3 2.2 1 1 1 2 2 2 1 FMN-dependent dehydrogenase DHO_dh PF01180.21 CDL01022.1 - 0.00055 19.2 0.5 0.00088 18.6 0.5 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 CDL01022.1 - 0.0006 19.3 0.3 0.02 14.3 0.1 2.2 1 1 1 2 2 2 1 Histidine biosynthesis protein Glu_synthase PF01645.17 CDL01022.1 - 0.31 10.1 3.8 5.5 6.0 3.8 2.3 1 1 0 1 1 1 0 Conserved region in glutamate synthase AA_kinase PF00696.28 CDL01023.1 - 3.7e-48 164.2 3.1 3.7e-48 164.2 3.1 1.5 2 0 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 CDL01023.1 - 1.1e-20 73.0 3.1 5.5e-14 51.6 0.2 3.1 4 0 0 4 4 4 2 ACT domain ACT_7 PF13840.6 CDL01023.1 - 2e-19 69.1 2.7 1.4e-14 53.6 0.8 2.6 2 0 0 2 2 2 2 ACT domain NAD_binding_7 PF13241.6 CDL01023.1 - 0.11 13.0 2.6 8.1 6.9 0.1 3.3 3 1 0 3 3 3 0 Putative NAD(P)-binding ACT_4 PF13291.6 CDL01023.1 - 0.12 13.0 1.7 3.5 8.3 0.1 2.7 2 0 0 2 2 2 0 ACT domain GTP_EFTU_D4 PF14578.6 CDL01023.1 - 0.63 10.0 5.6 0.1 12.5 0.7 2.3 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Methyltransf_11 PF08241.12 CDL01024.1 - 2.1e-20 73.2 0.0 4e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL01024.1 - 3.3e-19 69.3 0.0 6.3e-19 68.4 0.0 1.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL01024.1 - 2.6e-16 59.8 0.0 3.1e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL01024.1 - 5.8e-16 59.0 0.0 9.2e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL01024.1 - 2.6e-12 47.3 0.0 4e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDL01024.1 - 2.1e-08 33.8 0.0 2.5e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 CDL01024.1 - 0.0001 21.9 0.0 0.00018 21.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain NodS PF05401.11 CDL01024.1 - 0.00014 21.5 0.0 0.00021 21.0 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) PrmA PF06325.13 CDL01024.1 - 0.00019 21.0 0.0 0.00026 20.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 CDL01024.1 - 0.00034 20.6 0.0 0.00052 20.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CDL01024.1 - 0.0046 15.9 0.0 0.0074 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) TehB PF03848.14 CDL01024.1 - 0.013 15.0 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB MetW PF07021.12 CDL01024.1 - 0.098 12.2 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.13 CDL01024.1 - 0.12 12.8 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase DUF3365 PF11845.8 CDL01025.1 - 7.4e-31 107.6 0.0 1.9e-30 106.3 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3365) PAS PF00989.25 CDL01025.1 - 4.7e-13 49.1 0.0 2.7e-12 46.7 0.0 2.3 2 1 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CDL01025.1 - 9.9e-12 45.0 0.0 1.7e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDL01025.1 - 1.8e-08 34.6 0.0 7.8e-08 32.6 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDL01025.1 - 0.00045 20.2 0.0 0.0016 18.4 0.0 1.9 1 0 0 1 1 1 1 PAS domain HisKA PF00512.25 CDL01025.1 - 0.019 15.0 1.2 0.16 12.0 0.0 3.0 3 1 1 4 4 4 0 His Kinase A (phospho-acceptor) domain CwsA PF10814.8 CDL01025.1 - 0.078 13.1 0.2 0.2 11.8 0.0 1.8 2 0 0 2 2 2 0 Cell wall synthesis protein CwsA PAS_10 PF13596.6 CDL01025.1 - 0.14 12.8 0.0 1.6 9.4 0.0 2.6 2 1 0 2 2 2 0 PAS domain HATPase_c PF02518.26 CDL01026.1 - 1.9e-23 83.1 0.1 3e-23 82.5 0.1 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CDL01026.1 - 0.0075 16.2 0.2 0.05 13.5 0.2 2.1 1 1 0 1 1 1 1 GHKL domain HisKA PF00512.25 CDL01026.1 - 0.0099 15.9 0.0 0.036 14.1 0.0 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PGM_PMM_I PF02878.16 CDL01027.1 - 4e-34 117.3 0.0 6.9e-34 116.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CDL01027.1 - 4.5e-32 110.6 0.0 7.3e-32 109.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CDL01027.1 - 9.8e-14 51.8 0.2 1.5e-11 44.8 0.2 2.5 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CDL01027.1 - 7.7e-09 35.6 0.0 2.1e-08 34.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain SnoaL_2 PF12680.7 CDL01027.1 - 0.59 10.8 2.6 41 4.9 0.1 3.5 2 1 1 3 3 3 0 SnoaL-like domain MCPsignal PF00015.21 CDL01028.1 - 1.8e-32 112.5 43.6 5e-30 104.6 24.3 3.4 1 1 2 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain PAS_3 PF08447.12 CDL01028.1 - 3e-15 56.3 0.0 5.5e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CDL01028.1 - 1.2e-11 44.6 0.0 3.2e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDL01028.1 - 1.1e-10 41.6 0.0 2.9e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 CDL01028.1 - 2.2e-05 24.4 0.0 6e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDL01028.1 - 0.00059 20.1 0.0 0.003 17.8 0.0 2.2 2 0 0 2 2 2 1 PAS fold DUF1664 PF07889.12 CDL01028.1 - 0.01 15.9 13.1 0.4 10.7 1.5 4.0 2 1 1 3 3 3 2 Protein of unknown function (DUF1664) HAMP PF00672.25 CDL01028.1 - 0.031 14.7 2.2 0.25 11.8 0.0 3.4 3 0 0 3 3 2 0 HAMP domain IlvC PF01450.19 CDL01028.1 - 0.093 13.0 5.4 3.4 8.0 0.0 3.5 2 1 2 4 4 4 0 Acetohydroxy acid isomeroreductase, catalytic domain GP40 PF11025.8 CDL01028.1 - 0.17 11.6 8.8 3.7 7.3 2.7 3.0 2 1 0 3 3 3 0 Glycoprotein GP40 of Cryptosporidium TMPIT PF07851.13 CDL01028.1 - 0.32 10.2 1.2 5.9 6.0 0.1 2.2 2 0 0 2 2 2 0 TMPIT-like protein Laminin_II PF06009.12 CDL01028.1 - 0.41 10.7 20.5 0.16 12.0 1.7 3.9 3 1 1 4 4 4 0 Laminin Domain II DprA_WH PF17782.1 CDL01028.1 - 0.41 10.8 5.0 0.79 9.9 2.8 2.6 2 0 0 2 2 2 0 DprA winged helix domain COG2 PF06148.11 CDL01028.1 - 1.6 8.8 8.6 4.8 7.3 0.7 3.7 2 2 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF948 PF06103.11 CDL01028.1 - 2.2 8.6 31.3 0.52 10.6 0.9 5.6 3 3 2 5 5 5 0 Bacterial protein of unknown function (DUF948) Syntaxin-6_N PF09177.11 CDL01028.1 - 6.3 7.4 9.4 4.8 7.8 2.8 3.3 3 1 0 3 3 3 0 Syntaxin 6, N-terminal TOBE PF03459.17 CDL01029.1 - 1.3e-34 118.2 0.2 4.9e-16 58.8 0.1 2.4 2 0 0 2 2 2 2 TOBE domain HTH_1 PF00126.27 CDL01029.1 - 8.5e-14 51.3 0.0 1.8e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family TOBE_2 PF08402.10 CDL01029.1 - 0.011 15.9 0.2 1.3 9.3 0.0 2.5 1 1 1 2 2 2 0 TOBE domain HTH_29 PF13551.6 CDL01029.1 - 0.074 13.1 0.2 0.29 11.2 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix HTH_28 PF13518.6 CDL01029.1 - 0.097 12.8 0.3 0.27 11.4 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain TOBE PF03459.17 CDL01030.1 - 9.9e-14 51.4 1.0 1.1e-13 51.3 1.0 1.0 1 0 0 1 1 1 1 TOBE domain SBP_bac_11 PF13531.6 CDL01031.1 - 1.1e-41 143.1 6.1 1.3e-41 142.9 6.1 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CDL01031.1 - 4.7e-12 46.5 3.0 1e-10 42.1 3.0 2.0 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3479 PF11965.8 CDL01031.1 - 0.01 16.0 0.0 1.8 8.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3479) SBP_bac_6 PF13343.6 CDL01031.1 - 0.071 12.5 0.3 0.2 11.0 0.1 1.8 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein MAGE_N PF12440.8 CDL01031.1 - 0.15 12.8 0.1 0.27 11.9 0.1 1.4 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal Peptidase_M24 PF00557.24 CDL01032.1 - 3.5e-51 173.9 0.4 4e-51 173.7 0.4 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 Sulf_transp PF04143.14 CDL01033.1 - 4e-68 230.3 40.0 4e-68 230.3 40.0 1.7 2 0 0 2 2 2 1 Sulphur transport DrsE_2 PF13686.6 CDL01034.1 - 2.5e-54 183.4 3.0 2.8e-54 183.2 3.0 1.0 1 0 0 1 1 1 1 DsrE/DsrF/DrsH-like family DrsE PF02635.15 CDL01034.1 - 1.7e-11 44.5 0.1 1.1e-10 41.9 0.1 1.9 1 1 0 1 1 1 1 DsrE/DsrF-like family RHH_4 PF13467.6 CDL01035.1 - 3.1e-27 94.2 0.4 1.4e-26 92.1 0.3 1.8 2 0 0 2 2 2 1 Ribbon-helix-helix domain RHH_1 PF01402.21 CDL01035.1 - 0.049 13.6 0.1 0.074 13.0 0.1 1.3 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family TusA PF01206.17 CDL01036.1 - 2.6e-22 78.4 0.0 2.9e-22 78.3 0.0 1.0 1 0 0 1 1 1 1 Sulfurtransferase TusA Thioredoxin_2 PF13098.6 CDL01037.1 - 0.21 12.1 0.0 3.4 8.2 0.0 2.1 1 1 0 1 1 1 0 Thioredoxin-like domain Haem_degrading PF03928.14 CDL01038.1 - 1.8e-26 92.5 1.9 2.1e-26 92.3 1.9 1.1 1 0 0 1 1 1 1 Haem-degrading PepSY_2 PF13670.6 CDL01038.1 - 0.02 14.9 1.0 0.042 13.9 1.0 1.6 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain DUF572 PF04502.13 CDL01039.1 - 0.0099 15.5 13.6 0.012 15.3 13.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF4404 PF14357.6 CDL01039.1 - 0.019 15.6 12.0 0.4 11.4 0.6 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF4404) TBCC_N PF16752.5 CDL01039.1 - 0.11 12.9 13.6 0.18 12.3 2.9 2.2 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain GET2 PF08690.10 CDL01039.1 - 1.4 8.5 8.6 4 7.0 0.9 2.0 1 1 1 2 2 2 0 GET complex subunit GET2 FAM184 PF15665.5 CDL01039.1 - 1.9 8.2 16.8 2.6 7.8 16.8 1.1 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B ALMT PF11744.8 CDL01039.1 - 3.3 6.4 7.3 3.9 6.2 7.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FliD_N PF02465.18 CDL01039.1 - 5 7.9 12.7 0.66 10.7 5.0 2.8 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus DUF2452 PF10504.9 CDL01039.1 - 8 5.9 7.9 3.4 7.1 4.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2452) FYDLN_acid PF09538.10 CDL01040.1 - 4.7e-27 94.8 4.6 5.2e-27 94.6 4.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) DZR PF12773.7 CDL01040.1 - 0.002 18.1 2.4 0.0034 17.4 2.4 1.3 1 0 0 1 1 1 1 Double zinc ribbon Zn-ribbon_8 PF09723.10 CDL01040.1 - 0.01 15.9 3.8 0.022 14.9 3.8 1.5 1 0 0 1 1 1 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 CDL01040.1 - 0.011 15.1 5.1 0.033 13.6 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain CpXC PF14353.6 CDL01040.1 - 0.023 14.7 0.3 0.023 14.7 0.3 2.5 1 1 1 2 2 2 0 CpXC protein DUF2072 PF09845.9 CDL01040.1 - 0.034 14.4 0.4 0.046 14.0 0.4 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein DUF4645 PF15488.6 CDL01040.1 - 0.039 13.4 0.1 0.042 13.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4645) zinc_ribbon_2 PF13240.6 CDL01040.1 - 0.053 13.3 0.1 0.053 13.3 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 CDL01040.1 - 0.12 12.4 2.5 0.19 11.7 2.5 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn_Tnp_IS1595 PF12760.7 CDL01040.1 - 0.16 12.0 8.3 1.1 9.3 1.7 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-NADH-PPase PF09297.11 CDL01040.1 - 0.24 11.1 6.3 2.8 7.7 1.0 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zf-HYPF PF07503.12 CDL01040.1 - 0.29 10.9 7.0 2.3 8.1 0.4 2.2 2 0 0 2 2 2 0 HypF finger DNA_RNApol_7kD PF03604.13 CDL01040.1 - 0.33 10.7 4.8 0.85 9.4 4.8 1.6 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 CDL01040.1 - 0.34 10.9 2.2 0.61 10.1 2.2 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_UBZ PF18439.1 CDL01040.1 - 0.83 9.3 0.1 0.83 9.3 0.1 2.6 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger TF_Zn_Ribbon PF08271.12 CDL01040.1 - 1.7 8.2 8.4 19 4.8 8.5 2.6 1 1 0 1 1 1 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.6 CDL01040.1 - 3.9 7.5 7.7 3.2 7.7 0.3 2.7 3 0 0 3 3 3 0 zinc-ribbon domain EPSP_synthase PF00275.20 CDL01041.1 - 2.6e-107 359.1 0.0 2.9e-107 358.9 0.0 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Cytidylate_kin PF02224.18 CDL01042.1 - 9.1e-53 179.1 0.2 2.8e-52 177.5 0.2 1.6 1 1 0 1 1 1 1 Cytidylate kinase Cytidylate_kin2 PF13189.6 CDL01042.1 - 3.2e-05 24.2 0.3 0.00011 22.4 0.3 1.8 1 1 0 1 1 1 1 Cytidylate kinase-like family AAA_33 PF13671.6 CDL01042.1 - 4.7e-05 23.6 0.0 0.0028 17.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 CDL01042.1 - 0.0001 22.7 0.0 0.0018 18.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDL01042.1 - 0.00011 22.8 0.0 0.00017 22.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain ADK PF00406.22 CDL01042.1 - 0.0039 17.3 0.0 0.0078 16.3 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase SKI PF01202.22 CDL01042.1 - 0.014 15.6 0.0 0.22 11.6 0.0 2.1 2 0 0 2 2 2 0 Shikimate kinase dNK PF01712.19 CDL01042.1 - 0.08 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase SVIP PF15811.5 CDL01042.1 - 5.8 7.4 6.2 0.42 11.1 0.7 1.9 2 0 0 2 2 2 0 Small VCP/p97-interacting protein S1 PF00575.23 CDL01043.1 - 1.8e-97 319.7 26.7 1.1e-20 73.8 0.1 6.1 6 0 0 6 6 6 6 S1 RNA binding domain S1_2 PF13509.6 CDL01043.1 - 5e-10 39.3 4.7 0.043 13.9 0.1 6.0 5 1 0 5 5 5 2 S1 domain PCB_OB PF17092.5 CDL01043.1 - 5e-09 36.9 4.9 0.65 10.8 0.0 5.8 2 2 3 6 6 6 3 Penicillin-binding protein OB-like domain RNase_II_C_S1 PF18614.1 CDL01043.1 - 0.0026 17.7 8.0 22 5.1 0.2 5.6 6 0 0 6 6 6 0 RNase II-type exonuclease C-terminal S1 domain LytB_WW PF18342.1 CDL01043.1 - 0.022 14.8 0.0 0.055 13.6 0.0 1.6 1 0 0 1 1 1 0 Endo-beta-N-acetylglucosaminidase LytB WW domain PLD_C PF12357.8 CDL01043.1 - 0.032 14.2 0.1 16 5.5 0.0 2.8 3 0 0 3 3 3 0 Phospholipase D C terminal SH3_4 PF06347.13 CDL01043.1 - 0.094 12.6 0.0 0.49 10.3 0.0 2.2 2 0 0 2 2 2 0 Bacterial SH3 domain RuvA_N PF01330.21 CDL01043.1 - 0.9 9.7 3.0 8.6 6.5 0.0 3.2 3 0 0 3 3 3 0 RuvA N terminal domain BPL_C PF02237.17 CDL01043.1 - 2.4 8.1 9.3 8.8 6.3 0.0 5.0 6 0 0 6 6 6 0 Biotin protein ligase C terminal domain CsrA PF02599.16 CDL01043.1 - 4.5 7.3 9.0 3.6 7.6 0.0 4.2 5 0 0 5 5 5 0 Global regulator protein family SpoIIE PF07228.12 CDL01044.1 - 6.6e-30 104.5 0.3 3.5e-28 98.9 0.1 2.3 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) HAMP PF00672.25 CDL01044.1 - 0.0028 18.0 0.0 0.0028 18.0 0.0 3.4 4 1 1 5 5 5 1 HAMP domain ADIP PF11559.8 CDL01044.1 - 0.027 14.6 0.6 0.06 13.4 0.3 1.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF5455 PF17537.2 CDL01044.1 - 0.065 13.6 1.8 0.19 12.1 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5455) DUF948 PF06103.11 CDL01044.1 - 1.4 9.3 4.4 37 4.7 1.8 3.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) GGDEF PF00990.21 CDL01045.1 - 3.1e-46 157.1 0.0 4.8e-46 156.4 0.0 1.3 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_4 PF08448.10 CDL01045.1 - 5.8e-16 58.7 0.6 2.3e-15 56.8 0.0 2.3 3 0 0 3 3 3 1 PAS fold Response_reg PF00072.24 CDL01045.1 - 1.7e-08 34.6 0.1 3e-08 33.8 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain PAS_9 PF13426.7 CDL01045.1 - 6.3e-06 26.4 0.0 2.7e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 CDL01045.1 - 6.9e-06 26.0 0.0 2.9e-05 24.0 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDL01045.1 - 3.5e-05 23.7 0.0 0.00063 19.7 0.0 3.1 2 0 0 2 2 2 1 PAS domain GGDEF_2 PF17853.1 CDL01045.1 - 0.0061 16.8 1.1 0.052 13.8 0.3 2.6 2 0 0 2 2 2 1 GGDEF-like domain GGDEF PF00990.21 CDL01046.1 - 2.8e-43 147.4 0.1 6.4e-43 146.3 0.0 1.7 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain PAS PF00989.25 CDL01046.1 - 3.4e-15 56.0 0.1 0.0033 17.4 0.0 4.9 5 0 0 5 5 5 3 PAS fold PAS_9 PF13426.7 CDL01046.1 - 3.3e-14 53.0 0.0 6.9e-05 23.0 0.0 4.0 3 1 0 3 3 3 3 PAS domain PAS_8 PF13188.7 CDL01046.1 - 1e-13 51.0 0.1 0.0035 17.3 0.0 3.8 3 0 0 3 3 3 3 PAS domain PAS_4 PF08448.10 CDL01046.1 - 1.7e-13 50.8 0.7 0.0071 16.6 0.0 5.2 5 1 1 6 6 6 4 PAS fold DUF748 PF05359.11 CDL01047.1 - 2.4e-30 105.7 10.6 1.3e-22 80.6 0.3 6.2 3 1 5 8 8 8 2 Domain of Unknown Function (DUF748) AsmA PF05170.14 CDL01047.1 - 0.0023 16.8 0.0 0.031 13.1 0.0 2.3 2 0 0 2 2 2 1 AsmA family OmpA PF00691.20 CDL01047.1 - 0.04 14.3 0.0 0.46 10.9 0.0 2.3 1 1 0 1 1 1 0 OmpA family Sigma70_r3 PF04539.16 CDL01047.1 - 0.062 13.4 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-70 region 3 TrkH PF02386.16 CDL01048.1 - 4.3e-50 170.6 13.5 4.3e-49 167.3 13.5 1.9 1 1 0 1 1 1 1 Cation transport protein TrkH PF02386.16 CDL01049.1 - 3.9e-58 197.1 21.2 2.1e-57 194.7 21.2 1.8 1 1 0 1 1 1 1 Cation transport protein SH PF01445.17 CDL01049.1 - 0.036 14.0 3.0 3.4 7.7 0.7 3.0 2 0 0 2 2 2 0 Viral small hydrophobic protein TssN PF17555.2 CDL01049.1 - 0.082 12.3 0.1 0.082 12.3 0.1 3.2 2 1 0 3 3 3 0 Type VI secretion system, TssN Trns_repr_metal PF02583.17 CDL01050.1 - 1.2e-20 73.6 0.6 1.4e-20 73.4 0.6 1.0 1 0 0 1 1 1 1 Metal-sensitive transcriptional repressor Cation_efflux PF01545.21 CDL01051.1 - 5.8e-37 127.4 10.2 7.2e-37 127.0 10.2 1.1 1 0 0 1 1 1 1 Cation efflux family Claudin_2 PF13903.6 CDL01051.1 - 1.6 8.5 11.0 35 4.1 12.3 2.2 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF805 PF05656.14 CDL01051.1 - 8.9 6.8 10.8 18 5.8 5.9 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF805) Phosphonate-bd PF12974.7 CDL01052.1 - 3.4e-34 118.5 1.4 4e-34 118.3 1.4 1.0 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 CDL01052.1 - 4.7e-07 29.5 0.0 6.7e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1 PF09084.11 CDL01052.1 - 1.2e-06 28.7 0.0 1.8e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like PBP_like PF12727.7 CDL01052.1 - 0.0031 16.7 0.5 0.006 15.7 0.5 1.4 1 0 0 1 1 1 1 PBP superfamily domain PAS_9 PF13426.7 CDL01053.1 - 1e-26 93.2 0.0 1.6e-15 57.2 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 CDL01053.1 - 1.8e-24 85.9 0.0 7.5e-17 61.4 0.0 2.6 2 0 0 2 2 2 2 PAS fold HATPase_c PF02518.26 CDL01053.1 - 8.7e-24 84.2 0.0 1.7e-23 83.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 CDL01053.1 - 1.2e-21 76.8 0.7 7.5e-13 48.6 0.1 3.2 3 0 0 3 3 3 2 PAS fold PAS_4 PF08448.10 CDL01053.1 - 1.2e-20 73.8 0.2 1.4e-10 41.4 0.0 2.8 2 0 0 2 2 2 2 PAS fold HAMP PF00672.25 CDL01053.1 - 2.5e-15 56.6 0.3 1.2e-14 54.4 0.3 2.3 1 0 0 1 1 1 1 HAMP domain HisKA PF00512.25 CDL01053.1 - 2.7e-13 49.7 0.4 1e-12 47.9 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 CDL01053.1 - 4.7e-11 42.5 0.0 4.1e-07 29.9 0.0 3.2 2 0 0 2 2 2 2 PAS domain TadE PF07811.12 CDL01053.1 - 0.2 11.9 4.2 6.4 7.1 0.2 2.8 2 0 0 2 2 2 0 TadE-like protein Bac_DNA_binding PF00216.21 CDL01054.1 - 1e-31 109.0 0.0 1.1e-31 108.9 0.0 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein HU-HIG PF18291.1 CDL01054.1 - 5.4e-07 29.7 0.0 6.4e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif HU-CCDC81_euk_1 PF14908.6 CDL01054.1 - 0.00047 20.3 0.0 0.00058 20.0 0.0 1.1 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 1 HU-DNA_bdg PF14848.6 CDL01054.1 - 0.0021 18.0 0.0 0.0044 17.0 0.0 1.5 1 1 0 1 1 1 1 DNA-binding domain HU-CCDC81_euk_2 PF18289.1 CDL01054.1 - 0.015 15.4 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 HU-CCDC81_bac_2 PF18175.1 CDL01054.1 - 0.048 13.5 0.0 0.064 13.1 0.0 1.3 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 HU-CCDC81_bac_1 PF18174.1 CDL01054.1 - 0.094 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 1 LapA_dom PF06305.11 CDL01055.1 - 4.5e-12 45.6 2.3 7.3e-10 38.5 0.0 2.2 1 1 1 2 2 2 2 Lipopolysaccharide assembly protein A domain DUF3176 PF11374.8 CDL01055.1 - 0.035 14.3 0.2 0.055 13.7 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3176) DUF4231 PF14015.6 CDL01055.1 - 0.24 11.9 0.9 0.74 10.3 0.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4231) DPM2 PF07297.12 CDL01055.1 - 1.1 9.6 5.5 1.6 9.1 2.2 2.0 1 1 1 2 2 2 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) OMPdecase PF00215.24 CDL01056.1 - 7.6e-41 140.2 0.2 8.6e-41 140.0 0.2 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family PRAI PF00697.22 CDL01057.1 - 1.6e-45 155.3 0.0 1.8e-45 155.1 0.0 1.0 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Amidase_2 PF01510.25 CDL01058.1 - 7.2e-34 117.0 0.0 1.1e-33 116.4 0.0 1.2 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase EamA PF00892.20 CDL01059.1 - 1.7e-37 128.7 36.3 9.7e-20 71.1 12.2 2.1 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 CDL01059.1 - 0.00019 20.7 0.6 0.0019 17.4 0.0 2.2 2 0 0 2 2 2 1 Nucleotide-sugar transporter TPT PF03151.16 CDL01059.1 - 0.00093 18.6 8.3 0.0012 18.2 8.3 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family DUF3007 PF11460.8 CDL01059.1 - 0.26 11.6 7.3 0.34 11.2 3.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) DUF2339 PF10101.9 CDL01059.1 - 1.2 7.6 38.7 2.4 6.7 25.1 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2339) PUNUT PF16913.5 CDL01059.1 - 4.1 6.5 14.7 0.77 8.9 3.5 2.9 3 0 0 3 3 3 0 Purine nucleobase transmembrane transport ABC_tran PF00005.27 CDL01060.1 - 5.1e-47 159.8 0.0 3.8e-22 79.3 0.0 3.4 3 1 0 3 3 3 2 ABC transporter ABC_tran_CTD PF16326.5 CDL01060.1 - 7.7e-21 74.1 3.3 1.7e-20 73.0 3.3 1.6 1 0 0 1 1 1 1 ABC transporter C-terminal domain AAA_21 PF13304.6 CDL01060.1 - 6.5e-18 65.6 5.1 0.00029 20.8 0.2 4.3 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDL01060.1 - 3.4e-09 36.5 0.2 0.059 12.8 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDL01060.1 - 7.2e-09 36.3 3.2 0.0028 18.0 0.2 3.5 3 1 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 CDL01060.1 - 7.1e-08 32.1 1.4 0.0012 18.5 0.2 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CDL01060.1 - 1.8e-06 28.6 7.0 0.04 14.4 0.2 3.3 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.6 CDL01060.1 - 2.3e-06 27.6 1.1 0.0053 16.5 0.0 2.8 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 CDL01060.1 - 5.3e-06 26.5 0.0 0.03 14.4 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 CDL01060.1 - 9.8e-06 25.9 1.5 0.57 10.4 0.1 3.5 3 1 0 3 3 3 2 AAA domain NACHT PF05729.12 CDL01060.1 - 9.9e-06 25.6 0.0 0.28 11.1 0.0 3.0 3 0 0 3 3 3 2 NACHT domain RsgA_GTPase PF03193.16 CDL01060.1 - 1.2e-05 25.3 0.6 0.13 12.1 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase Roc PF08477.13 CDL01060.1 - 3.7e-05 23.9 0.0 0.16 12.2 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 CDL01060.1 - 0.00012 22.3 0.9 0.55 10.4 0.0 3.7 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 CDL01060.1 - 0.00021 21.7 0.0 1.2 9.6 0.0 3.2 3 0 0 3 3 3 1 RNA helicase AAA_30 PF13604.6 CDL01060.1 - 0.00021 21.1 4.9 0.087 12.5 0.0 3.1 4 0 0 4 4 3 2 AAA domain AAA_25 PF13481.6 CDL01060.1 - 0.00027 20.6 5.9 0.028 14.0 0.4 3.6 3 1 0 3 3 3 2 AAA domain AAA_24 PF13479.6 CDL01060.1 - 0.00068 19.4 0.2 0.51 10.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CDL01060.1 - 0.002 18.6 0.0 1.2 9.6 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CDL01060.1 - 0.0022 17.3 0.4 1.7 7.9 0.0 2.6 3 0 0 3 3 2 1 Zeta toxin cobW PF02492.19 CDL01060.1 - 0.0023 17.5 1.4 0.71 9.4 0.2 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CDL01060.1 - 0.0024 16.9 1.6 0.48 9.4 0.3 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 CDL01060.1 - 0.0032 17.7 1.1 0.77 10.0 0.2 2.9 3 0 0 3 3 2 1 AAA domain DUF1843 PF08898.10 CDL01060.1 - 0.0033 17.9 0.1 0.0094 16.4 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1843) PduV-EutP PF10662.9 CDL01060.1 - 0.004 16.9 0.4 2.2 8.0 0.1 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 CDL01060.1 - 0.0059 16.6 0.1 5.2 7.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CDL01060.1 - 0.0072 16.9 0.1 3.5 8.2 0.0 3.3 3 0 0 3 3 3 1 AAA domain TsaE PF02367.17 CDL01060.1 - 0.01 15.9 1.2 0.59 10.2 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 CDL01060.1 - 0.011 15.7 0.0 0.77 9.6 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ABC_tran_Xtn PF12848.7 CDL01060.1 - 0.016 15.2 0.3 0.4 10.7 0.0 2.6 2 0 0 2 2 2 0 ABC transporter AAA_13 PF13166.6 CDL01060.1 - 0.023 13.4 1.4 4.5 5.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_14 PF13173.6 CDL01060.1 - 0.027 14.5 0.0 16 5.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.25 CDL01060.1 - 0.027 14.1 0.1 1.9 8.1 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain RuvB_N PF05496.12 CDL01060.1 - 0.029 14.1 0.1 2.6 7.8 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain MobB PF03205.14 CDL01060.1 - 0.038 13.9 0.2 1.9 8.4 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DLIC PF05783.11 CDL01060.1 - 0.041 12.7 0.4 0.51 9.1 0.0 2.5 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) AAA_7 PF12775.7 CDL01060.1 - 0.05 13.1 0.8 9.8 5.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 CDL01060.1 - 0.059 13.1 2.4 3.8 7.2 0.0 3.1 4 0 0 4 4 3 0 IstB-like ATP binding protein NTPase_1 PF03266.15 CDL01060.1 - 0.074 13.0 0.6 6.7 6.6 0.1 2.5 2 0 0 2 2 2 0 NTPase MukB PF04310.12 CDL01060.1 - 0.081 12.7 0.1 10 5.9 0.0 2.5 2 0 0 2 2 2 0 MukB N-terminal Arf PF00025.21 CDL01060.1 - 0.091 12.2 0.4 6.7 6.1 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family Ras PF00071.22 CDL01060.1 - 0.13 11.9 0.1 2.7 7.6 0.1 2.2 2 0 0 2 2 2 0 Ras family SRP54 PF00448.22 CDL01060.1 - 0.15 11.7 0.7 9 5.9 0.2 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ATP_bind_1 PF03029.17 CDL01060.1 - 0.18 11.5 0.0 7.8 6.2 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Rad17 PF03215.15 CDL01060.1 - 0.19 11.7 0.0 4.7 7.1 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain Mg_chelatase PF01078.21 CDL01060.1 - 0.35 10.2 1.1 12 5.2 0.2 2.5 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 CDL01060.1 - 0.58 9.3 2.7 17 4.5 0.1 2.3 2 0 0 2 2 2 0 NB-ARC domain SPOR PF05036.13 CDL01061.1 - 0.007 16.7 0.1 0.013 15.8 0.1 1.5 1 0 0 1 1 1 1 Sporulation related domain DUF3242 PF11586.8 CDL01061.1 - 0.096 12.4 0.1 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3242) PrmA PF06325.13 CDL01062.1 - 8.6e-56 189.5 0.0 1e-55 189.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CDL01062.1 - 5.3e-09 36.7 0.0 1.8e-08 35.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CDL01062.1 - 7.3e-09 35.4 0.0 1.2e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDL01062.1 - 2.5e-06 27.4 0.0 4e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CDL01062.1 - 4.9e-05 23.2 0.0 6.8e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_11 PF08241.12 CDL01062.1 - 9.3e-05 23.0 0.0 0.00023 21.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_16 PF10294.9 CDL01062.1 - 9.6e-05 22.2 0.0 0.00018 21.3 0.0 1.4 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 CDL01062.1 - 0.00012 21.9 0.0 0.00022 21.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 CDL01062.1 - 0.00029 20.4 0.0 0.00042 19.9 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_12 PF08242.12 CDL01062.1 - 0.00064 20.4 0.0 0.0013 19.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDL01062.1 - 0.0012 18.5 0.0 0.0019 17.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_18 PF12847.7 CDL01062.1 - 0.014 15.3 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CDL01062.1 - 0.026 14.3 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TRM PF02005.16 CDL01062.1 - 0.057 12.6 0.0 0.073 12.2 0.0 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase UPF0020 PF01170.18 CDL01062.1 - 0.061 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 ParE_toxin PF05016.15 CDL01063.1 - 1.3e-10 41.7 0.0 1.5e-10 41.5 0.0 1.0 1 0 0 1 1 1 1 ParE toxin of type II toxin-antitoxin system, parDE AstE_AspA PF04952.14 CDL01063.1 - 0.014 14.4 0.0 0.46 9.5 0.0 2.0 1 1 1 2 2 2 0 Succinylglutamate desuccinylase / Aspartoacylase family ParD_antitoxin PF03693.14 CDL01064.1 - 6.8e-09 36.0 0.1 8.2e-09 35.8 0.1 1.2 1 0 0 1 1 1 1 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH RHH_8 PF17723.1 CDL01064.1 - 0.056 13.6 0.1 0.062 13.5 0.1 1.1 1 0 0 1 1 1 0 Ribbon-Helix-Helix transcriptional regulator family UvrD-helicase PF00580.21 CDL01065.1 - 7e-77 259.0 0.0 1.6e-76 257.8 0.0 1.6 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CDL01065.1 - 3.2e-61 207.7 0.0 1.7e-59 202.0 0.0 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CDL01065.1 - 2.3e-30 105.9 0.0 6.5e-30 104.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDL01065.1 - 3.6e-10 39.9 0.1 4.4e-05 23.3 0.5 2.5 1 1 0 2 2 2 2 AAA domain UvrD_C_2 PF13538.6 CDL01065.1 - 1.5e-09 37.5 0.0 6.1e-09 35.6 0.0 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 CDL01065.1 - 1.7e-05 24.6 0.1 1.3 8.7 0.0 3.6 3 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 CDL01065.1 - 0.0095 15.7 0.0 0.092 12.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDL01065.1 - 0.039 14.3 0.3 0.2 12.1 0.3 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_12 PF13087.6 CDL01065.1 - 0.058 13.0 0.0 1.3 8.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain DUF3553 PF12073.8 CDL01065.1 - 0.14 11.9 0.1 0.4 10.4 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3553) Radical_SAM PF04055.21 CDL01066.1 - 1.1e-13 51.9 0.0 3e-13 50.5 0.0 1.7 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 CDL01066.1 - 0.029 14.5 0.3 0.13 12.4 0.3 1.9 1 1 0 1 1 1 0 4Fe-4S single cluster domain AA_kinase PF00696.28 CDL01067.1 - 4.2e-44 151.0 2.5 5.2e-44 150.7 2.5 1.1 1 0 0 1 1 1 1 Amino acid kinase family DMRL_synthase PF00885.19 CDL01067.1 - 0.031 14.1 0.2 0.059 13.2 0.2 1.4 1 0 0 1 1 1 0 6,7-dimethyl-8-ribityllumazine synthase GatB_Yqey PF02637.18 CDL01067.1 - 0.057 13.3 0.0 0.74 9.7 0.0 2.4 2 1 0 2 2 2 0 GatB domain MMR_HSR1 PF01926.23 CDL01068.1 - 3.8e-22 78.5 0.0 5.9e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDL01068.1 - 1.9e-08 34.4 0.2 3.7e-05 23.7 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CDL01068.1 - 1.2e-07 31.4 0.0 2e-07 30.7 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDL01068.1 - 5.4e-06 26.1 0.0 6.8e-05 22.5 0.0 2.1 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CDL01068.1 - 2.7e-05 24.3 0.1 0.0069 16.5 0.1 2.3 1 1 1 2 2 2 2 Dynamin family Septin PF00735.18 CDL01068.1 - 0.00013 21.4 0.6 0.31 10.3 0.0 2.5 2 1 0 2 2 2 2 Septin cobW PF02492.19 CDL01068.1 - 0.016 14.8 0.5 0.044 13.4 0.2 1.7 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 CDL01068.1 - 0.035 14.3 0.1 0.12 12.6 0.0 1.9 1 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1_Xtn PF16897.5 CDL01068.1 - 0.042 13.9 0.0 0.073 13.1 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain SRPRB PF09439.10 CDL01068.1 - 0.082 12.3 0.0 0.14 11.6 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AIG1 PF04548.16 CDL01068.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 AIG1 family ABC_tran PF00005.27 CDL01068.1 - 0.14 12.7 0.0 0.27 11.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter YcgL PF05166.13 CDL01068.1 - 0.15 12.4 0.1 0.26 11.7 0.1 1.3 1 0 0 1 1 1 0 YcgL domain YidC_periplas PF14849.6 CDL01069.1 - 3.5e-85 286.3 0.0 4.4e-85 286.0 0.0 1.1 1 0 0 1 1 1 1 YidC periplasmic domain 60KD_IMP PF02096.20 CDL01069.1 - 4.1e-60 202.5 10.4 5.8e-60 202.0 10.4 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein YidD PF01809.18 CDL01070.1 - 5.8e-30 103.0 0.2 7.5e-30 102.6 0.2 1.1 1 0 0 1 1 1 1 Putative membrane protein insertion efficiency factor HTH_Tnp_ISL3 PF13542.6 CDL01070.1 - 0.07 12.6 0.0 0.2 11.1 0.0 1.8 1 1 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Ribonuclease_P PF00825.18 CDL01071.1 - 7.1e-23 80.8 0.0 8.7e-23 80.5 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease P Gag_p30 PF02093.16 CDL01071.1 - 0.05 13.1 0.0 0.058 12.9 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein Methyltransf_25 PF13649.6 CDL01072.1 - 1.1e-14 54.9 0.0 1.8e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL01072.1 - 1.8e-13 50.9 0.0 2.9e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL01072.1 - 3.1e-13 49.9 0.0 3.8e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL01072.1 - 1.3e-11 44.6 0.0 1.6e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL01072.1 - 1.5e-10 41.7 0.0 2.4e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDL01072.1 - 1.8e-05 24.3 0.0 2.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain DOT1 PF08123.13 CDL01072.1 - 0.00088 18.9 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 CDL01072.1 - 0.00089 19.3 0.0 0.0013 18.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDL01072.1 - 0.011 15.5 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 CDL01072.1 - 0.02 13.9 0.0 0.026 13.6 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase MetW PF07021.12 CDL01072.1 - 0.032 13.8 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_33 PF10017.9 CDL01072.1 - 0.045 12.9 0.0 0.055 12.6 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent FtsJ PF01728.19 CDL01072.1 - 0.063 13.4 0.0 0.083 13.0 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 CDL01072.1 - 0.13 11.5 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain DUF938 PF06080.12 CDL01072.1 - 0.14 11.9 0.0 0.47 10.2 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF938) Ubie_methyltran PF01209.18 CDL01072.1 - 0.14 11.4 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 CDL01072.1 - 0.24 10.8 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Cytochrome_cB PF11783.8 CDL01073.1 - 6.3e-67 224.8 0.1 6.3e-67 224.8 0.1 3.4 5 0 0 5 5 5 1 Cytochrome c bacterial Cytochrome_C7 PF14522.6 CDL01073.1 - 8e-10 38.6 28.4 0.0073 16.3 12.6 4.9 2 1 2 4 4 4 4 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 CDL01073.1 - 6.4e-06 26.6 29.7 0.0042 17.5 0.4 5.2 3 1 2 5 5 5 1 Cytochrome c3 Paired_CXXCH_1 PF09699.10 CDL01073.1 - 4.5e-05 23.1 39.1 0.52 10.1 0.1 6.8 5 1 0 6 6 6 5 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_C554 PF13435.6 CDL01073.1 - 0.0023 18.8 33.9 0.0093 16.9 5.7 6.0 3 2 3 6 6 6 2 Cytochrome c554 and c-prime Atu4866 PF11512.8 CDL01073.1 - 0.083 13.3 0.1 0.43 11.0 0.0 2.1 2 0 0 2 2 2 0 Agrobacterium tumefaciens protein Atu4866 Cytochrome_CBB3 PF13442.6 CDL01073.1 - 0.15 12.4 40.4 12 6.3 0.0 8.2 4 2 3 7 7 7 0 Cytochrome C oxidase, cbb3-type, subunit III DUF2180 PF09947.9 CDL01073.1 - 0.93 9.5 5.2 0.37 10.8 0.5 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2180) Cytochrom_NNT PF03264.14 CDL01073.1 - 1 9.0 25.7 0.26 11.0 3.2 5.4 4 2 1 5 5 5 0 NapC/NirT cytochrome c family, N-terminal region Cytochrom_CIII PF02085.16 CDL01073.1 - 10 6.6 35.5 20 5.6 8.0 5.2 3 2 3 6 6 6 0 Class III cytochrome C family Ni_hydr_CYTB PF01292.20 CDL01074.1 - 4.1e-24 85.2 20.4 4.7e-24 85.0 20.4 1.0 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 DUF4405 PF14358.6 CDL01074.1 - 0.012 16.1 7.7 0.012 16.1 7.7 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4405) DUF2157 PF09925.9 CDL01074.1 - 5.8 6.7 13.5 23 4.8 13.3 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) DUF2141 PF09912.9 CDL01075.1 - 4.1e-29 100.8 0.0 4.8e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2141) fn3_3 PF14686.6 CDL01075.1 - 0.043 13.6 0.1 9.1 6.2 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide lyase family 4, domain II Cytochrom_C_2 PF01322.20 CDL01077.1 - 0.0042 18.0 0.2 0.0054 17.6 0.2 1.3 1 0 0 1 1 1 1 Cytochrome C' Erythro_esteras PF05139.14 CDL01077.1 - 0.046 13.5 1.2 0.056 13.3 1.2 1.0 1 0 0 1 1 1 0 Erythromycin esterase TrbC PF04956.13 CDL01079.1 - 0.24 11.6 2.8 0.3 11.3 2.8 1.2 1 0 0 1 1 1 0 TrbC/VIRB2 family FancD2 PF14631.6 CDL01079.1 - 1.8 5.9 5.3 2 5.7 5.3 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease tRNA-synt_2c PF01411.19 CDL01080.1 - 3.1e-212 706.0 0.0 3.7e-212 705.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) DHHA1 PF02272.19 CDL01080.1 - 5.6e-22 78.7 4.7 1.4e-21 77.4 4.7 1.7 1 0 0 1 1 1 1 DHHA1 domain tRNA_SAD PF07973.14 CDL01080.1 - 8.5e-19 67.4 0.1 2.1e-18 66.2 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Defensin_propep PF00879.18 CDL01081.1 - 0.089 13.1 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Defensin propeptide ABC_tran PF00005.27 CDL01083.1 - 3.1e-57 192.9 0.0 3.4e-27 95.6 0.0 2.2 2 0 0 2 2 2 2 ABC transporter oligo_HPY PF08352.12 CDL01083.1 - 2.9e-14 53.3 0.0 2.5e-06 27.9 0.0 2.5 2 0 0 2 2 2 2 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 CDL01083.1 - 4.2e-14 53.1 7.8 1.5e-05 25.0 0.1 4.0 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDL01083.1 - 3.2e-10 39.8 1.3 0.0024 17.4 0.0 3.7 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDL01083.1 - 1.2e-07 32.1 4.8 0.0081 16.4 0.1 3.7 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDL01083.1 - 1.4e-05 25.6 5.0 0.04 14.3 1.3 2.8 2 2 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CDL01083.1 - 1.9e-05 24.3 1.5 0.19 11.5 0.4 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain Mg_chelatase PF01078.21 CDL01083.1 - 0.00048 19.6 2.0 0.73 9.2 0.0 3.0 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CDL01083.1 - 0.00081 18.9 0.4 0.28 10.7 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region Pox_A32 PF04665.12 CDL01083.1 - 0.00095 18.7 0.8 1.3 8.4 0.3 2.5 2 0 0 2 2 2 2 Poxvirus A32 protein RsgA_GTPase PF03193.16 CDL01083.1 - 0.00098 19.1 1.4 1.1 9.1 0.3 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_25 PF13481.6 CDL01083.1 - 0.0014 18.3 7.4 1.9 8.0 0.1 4.0 3 1 0 3 3 3 1 AAA domain NACHT PF05729.12 CDL01083.1 - 0.0018 18.2 0.7 2.5 8.0 0.5 2.6 2 0 0 2 2 2 2 NACHT domain AAA_33 PF13671.6 CDL01083.1 - 0.0022 18.2 0.1 2 8.6 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CDL01083.1 - 0.0036 17.1 2.4 0.36 10.5 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 CDL01083.1 - 0.0038 17.2 2.2 2.3 8.2 0.0 3.2 4 0 0 4 4 2 1 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 CDL01083.1 - 0.0044 16.3 0.2 2.1 7.4 0.2 2.8 2 1 0 2 2 2 1 NB-ARC domain ATP-synt_ab PF00006.25 CDL01083.1 - 0.0048 16.6 0.1 1.7 8.3 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain SbcCD_C PF13558.6 CDL01083.1 - 0.0098 16.1 0.4 2 8.7 0.0 3.5 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit FtsK_SpoIIIE PF01580.18 CDL01083.1 - 0.01 15.2 1.6 9.6 5.5 0.1 3.2 3 0 0 3 3 3 0 FtsK/SpoIIIE family DUF87 PF01935.17 CDL01083.1 - 0.011 15.9 2.6 0.75 9.9 0.0 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_24 PF13479.6 CDL01083.1 - 0.014 15.1 0.3 6.1 6.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 CDL01083.1 - 0.014 15.4 0.6 7.5 6.6 0.3 2.8 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2075 PF09848.9 CDL01083.1 - 0.019 14.3 0.1 3.6 6.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 CDL01083.1 - 0.027 14.9 0.4 19 5.7 0.0 3.6 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 CDL01083.1 - 0.047 13.6 1.4 0.34 10.8 0.3 2.6 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.17 CDL01083.1 - 0.05 13.3 5.3 1.8 8.3 0.0 3.5 4 0 0 4 4 4 0 IstB-like ATP binding protein ATPase PF06745.13 CDL01083.1 - 0.055 12.8 3.3 0.72 9.2 0.5 2.3 2 0 0 2 2 2 0 KaiC AAA_13 PF13166.6 CDL01083.1 - 0.062 11.9 0.1 1 7.9 0.0 2.5 3 0 0 3 3 3 0 AAA domain TIP49 PF06068.13 CDL01083.1 - 0.12 11.6 0.6 13 4.8 0.2 2.2 2 0 0 2 2 2 0 TIP49 P-loop domain Sigma54_activat PF00158.26 CDL01083.1 - 0.13 12.0 3.6 2.6 7.7 0.0 3.1 4 0 0 4 4 3 0 Sigma-54 interaction domain GvpD PF07088.11 CDL01083.1 - 0.13 10.8 3.0 10 4.6 0.0 3.4 5 0 0 5 5 5 0 GvpD gas vesicle protein ABC_ATPase PF09818.9 CDL01083.1 - 0.14 11.0 4.2 2.6 6.7 0.0 3.6 3 2 0 3 3 3 0 Predicted ATPase of the ABC class APS_kinase PF01583.20 CDL01083.1 - 0.15 12.0 0.4 9.5 6.1 0.1 2.3 2 0 0 2 2 2 0 Adenylylsulphate kinase TrwB_AAD_bind PF10412.9 CDL01083.1 - 0.19 10.6 1.2 3.7 6.3 0.2 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Cuticle_1 PF08140.11 CDL01083.1 - 0.2 11.7 4.2 5.5 7.1 0.4 3.5 3 0 0 3 3 3 0 Crustacean cuticle protein repeat PRK PF00485.18 CDL01083.1 - 0.27 10.9 0.5 8.7 6.0 0.2 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family TsaE PF02367.17 CDL01083.1 - 0.33 11.0 0.9 24 4.9 0.4 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AIG1 PF04548.16 CDL01083.1 - 0.43 9.9 1.4 0.57 9.5 0.0 1.8 2 0 0 2 2 2 0 AIG1 family BPD_transp_1 PF00528.22 CDL01084.1 - 1.2e-25 90.3 11.0 1.2e-25 90.3 11.0 1.6 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 CDL01084.1 - 0.00013 21.9 0.6 0.00013 21.9 0.6 3.7 3 1 0 3 3 3 1 N-terminal TM domain of oligopeptide transport permease C LRR19-TM PF15176.6 CDL01084.1 - 4.3 7.4 5.8 1.4 9.0 0.0 2.6 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain BPD_transp_1 PF00528.22 CDL01085.1 - 3.9e-37 127.8 9.7 3.9e-37 127.8 9.7 1.6 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_5 PF00496.22 CDL01086.1 - 2.6e-82 276.8 0.6 4e-82 276.2 0.6 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle Inositol_P PF00459.25 CDL01087.1 - 5.7e-49 167.1 0.0 7.2e-49 166.7 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family CTP_transf_3 PF02348.19 CDL01088.1 - 9.7e-37 127.0 0.0 1.3e-36 126.6 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 CDL01088.1 - 6.4e-12 46.1 1.1 8.6e-12 45.7 1.1 1.3 1 1 0 1 1 1 1 MobA-like NTP transferase domain DUF2064 PF09837.9 CDL01088.1 - 0.013 15.4 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) PDT PF00800.18 CDL01089.1 - 6.3e-52 176.0 0.0 7.8e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 CDL01089.1 - 0.0052 16.5 0.0 0.02 14.6 0.0 2.0 2 0 0 2 2 2 1 ACT domain KorB PF08535.10 CDL01089.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 KorB domain TetR_C_7 PF14246.6 CDL01090.1 - 2.8e-25 88.6 0.0 4.1e-25 88.1 0.0 1.2 1 0 0 1 1 1 1 AefR-like transcriptional repressor, C-terminal domain TetR_N PF00440.23 CDL01090.1 - 3.9e-18 65.0 0.4 6.2e-18 64.3 0.4 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_11 PF16859.5 CDL01090.1 - 3.2e-07 30.7 0.1 6e-07 29.8 0.1 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain HTH_22 PF13309.6 CDL01090.1 - 0.018 15.1 0.6 0.037 14.1 0.1 1.7 2 0 0 2 2 2 0 HTH domain LacI PF00356.21 CDL01090.1 - 0.06 13.1 0.6 0.11 12.3 0.6 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HTH_Tnp_1_2 PF13022.6 CDL01090.1 - 0.065 13.4 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase HTH_40 PF14493.6 CDL01090.1 - 0.076 13.5 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_17 PF12728.7 CDL01090.1 - 0.094 12.9 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 CDL01090.1 - 0.096 12.5 0.0 0.26 11.2 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain UvrD-helicase PF00580.21 CDL01091.1 - 1.9e-51 175.4 0.0 4.4e-51 174.3 0.0 1.6 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 CDL01091.1 - 1.1e-18 67.9 0.0 2.5e-17 63.6 0.0 2.6 1 1 0 1 1 1 1 AAA domain UvrD_C PF13361.6 CDL01091.1 - 3e-16 59.8 0.0 6.8e-12 45.4 0.0 2.2 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 CDL01091.1 - 2.3e-11 43.3 1.1 0.00011 22.0 1.4 2.7 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain PDDEXK_1 PF12705.7 CDL01091.1 - 6.1e-07 29.6 0.0 2.6e-06 27.5 0.0 2.1 2 0 0 2 2 2 1 PD-(D/E)XK nuclease superfamily AAA_30 PF13604.6 CDL01091.1 - 0.025 14.3 0.2 0.025 14.3 0.2 2.3 3 0 0 3 3 3 0 AAA domain UNC45-central PF11701.8 CDL01091.1 - 0.072 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central PDDEXK_3 PF13366.6 CDL01092.1 - 5.4e-38 130.0 0.1 6.2e-38 129.8 0.1 1.0 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily DUF3199 PF11436.8 CDL01092.1 - 0.084 12.9 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3199) PDDEXK_1 PF12705.7 CDL01093.1 - 4.5e-23 82.5 0.0 1.2e-22 81.1 0.0 1.7 2 0 0 2 2 2 1 PD-(D/E)XK nuclease superfamily NTP_transf_3 PF12804.7 CDL01094.1 - 1.9e-13 51.1 0.9 2.1e-13 50.9 0.9 1.3 1 1 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 CDL01094.1 - 5.2e-12 45.9 0.0 2.5e-11 43.7 0.0 1.8 2 0 0 2 2 2 1 Nucleotidyl transferase IspD PF01128.19 CDL01094.1 - 0.0038 17.0 0.0 0.0096 15.7 0.0 1.6 2 0 0 2 2 2 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase APH PF01636.23 CDL01095.1 - 7e-26 91.6 11.4 7e-26 91.6 11.4 1.6 1 1 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDL01095.1 - 0.00062 19.2 0.0 0.55 9.5 0.0 2.1 2 0 0 2 2 2 2 Ecdysteroid kinase APH_6_hur PF04655.14 CDL01095.1 - 0.0026 17.2 0.7 0.016 14.6 0.7 2.1 1 1 0 1 1 1 1 Aminoglycoside/hydroxyurea antibiotic resistance kinase TsaE PF02367.17 CDL01096.1 - 5.8e-35 120.0 0.0 6.7e-35 119.8 0.0 1.0 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CDL01096.1 - 0.0012 19.0 0.0 0.0018 18.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDL01096.1 - 0.0023 18.4 0.0 0.0023 18.3 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CDL01096.1 - 0.0027 17.6 0.0 0.004 17.1 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CDL01096.1 - 0.005 17.1 0.0 0.0053 17.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CDL01096.1 - 0.0061 17.1 0.0 0.0065 17.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter NB-ARC PF00931.22 CDL01096.1 - 0.008 15.4 0.0 0.0085 15.3 0.0 1.1 1 0 0 1 1 1 1 NB-ARC domain ATPase_2 PF01637.18 CDL01096.1 - 0.023 14.6 0.0 0.032 14.1 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA PF00004.29 CDL01096.1 - 0.029 14.8 0.0 0.044 14.2 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CDL01096.1 - 0.034 14.5 0.0 0.044 14.2 0.0 1.2 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 CDL01096.1 - 0.043 13.3 0.0 0.057 12.9 0.0 1.1 1 0 0 1 1 1 0 P-loop containing dynein motor region CPT PF07931.12 CDL01096.1 - 0.044 13.6 0.0 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein TniB PF05621.11 CDL01096.1 - 0.061 12.7 0.0 0.086 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein TIP39 PF14980.6 CDL01096.1 - 0.062 13.2 2.2 0.076 12.9 0.7 1.8 2 0 0 2 2 2 0 TIP39 peptide RsgA_GTPase PF03193.16 CDL01096.1 - 0.068 13.1 0.0 0.15 11.9 0.0 1.5 2 0 0 2 2 2 0 RsgA GTPase AAA_25 PF13481.6 CDL01096.1 - 0.11 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDL01096.1 - 0.13 11.4 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Phage_integrase PF00589.22 CDL01097.1 - 8.4e-31 107.1 0.0 1.2e-30 106.5 0.0 1.2 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_1 PF02899.17 CDL01097.1 - 2.9e-15 56.3 0.1 1.1e-14 54.5 0.0 2.0 2 0 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 CDL01097.1 - 0.00073 20.0 0.0 0.0013 19.2 0.0 1.4 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain PIN PF01850.21 CDL01098.1 - 4.1e-14 53.1 0.2 5.2e-14 52.8 0.2 1.1 1 0 0 1 1 1 1 PIN domain PIN_2 PF10130.9 CDL01098.1 - 2.2e-05 24.7 0.0 2.6e-05 24.5 0.0 1.0 1 0 0 1 1 1 1 PIN domain RPT PF13446.6 CDL01099.1 - 0.015 15.2 0.1 0.026 14.4 0.1 1.3 1 0 0 1 1 1 0 A repeated domain in UCH-protein HemN_C PF06969.16 CDL01099.1 - 0.081 13.0 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 HemN C-terminal domain DUF349 PF03993.12 CDL01099.1 - 0.14 12.5 1.9 1.2 9.5 1.9 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF349) DUF484 PF04340.12 CDL01100.1 - 1.4e-28 100.1 0.0 7.7e-28 97.7 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF484 PriA_C PF18074.1 CDL01101.1 - 4.6e-18 65.8 0.0 9.4e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Primosomal protein N C-terminal domain PriA_3primeBD PF17764.1 CDL01101.1 - 1.7e-16 59.9 0.0 3.3e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 3′ DNA-binding domain (3′BD) DEAD PF00270.29 CDL01101.1 - 1.6e-12 47.5 0.0 2.8e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDL01101.1 - 4.1e-09 36.7 0.0 6.9e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PriA_CRR PF18319.1 CDL01101.1 - 5.9e-09 35.8 10.2 5.9e-09 35.8 10.2 2.4 3 0 0 3 3 3 1 PriA DNA helicase Cys-rich region (CRR) domain Helicase_C PF00271.31 CDL01101.1 - 2.5e-07 31.0 0.0 0.0033 17.8 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 CDL01101.1 - 5.2e-05 23.0 0.2 0.0001 22.1 0.2 1.4 1 0 0 1 1 1 1 AAA domain zinc-ribbons_6 PF07191.12 CDL01101.1 - 0.038 14.0 10.8 0.15 12.0 10.8 1.9 1 1 0 1 1 1 0 zinc-ribbons zinc_ribbon_12 PF11331.8 CDL01101.1 - 0.64 9.9 8.1 0.091 12.6 3.3 2.1 1 1 1 2 2 2 0 Probable zinc-ribbon domain PolC_DP2 PF03833.13 CDL01101.1 - 0.67 7.8 2.3 0.94 7.3 2.3 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 CDL01101.1 - 0.91 9.6 15.4 2.4 8.3 10.0 2.3 1 1 1 2 2 2 0 Double zinc ribbon OSCP PF00213.18 CDL01103.1 - 1.5e-49 168.5 0.8 1.6e-49 168.3 0.8 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit DUF4351 PF14261.6 CDL01103.1 - 0.049 13.7 0.2 0.14 12.3 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4351) ATP-synt_ab PF00006.25 CDL01104.1 - 3.8e-74 248.9 0.1 5.8e-74 248.3 0.1 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CDL01104.1 - 1.4e-46 157.9 0.3 2.7e-46 157.0 0.3 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CDL01104.1 - 5e-18 65.4 3.4 1.4e-17 63.9 3.4 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 CDL01104.1 - 1.1e-05 25.5 0.5 3.4e-05 23.9 0.5 1.9 1 1 0 1 1 1 1 HAS barrel domain ATP-synt PF00231.19 CDL01105.1 - 1.1e-95 320.5 0.1 1.3e-95 320.3 0.1 1.0 1 0 0 1 1 1 1 ATP synthase DUF5403 PF17395.2 CDL01105.1 - 0.16 12.2 1.0 1.8 8.9 0.0 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5403) ATP-synt_ab PF00006.25 CDL01106.1 - 1.1e-61 208.3 0.0 1.6e-61 207.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CDL01106.1 - 3.9e-22 78.5 0.9 8.2e-22 77.5 0.9 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RsgA_GTPase PF03193.16 CDL01106.1 - 0.00026 21.0 0.1 0.00066 19.6 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase T3SS_ATPase_C PF18269.1 CDL01106.1 - 0.011 15.5 0.2 0.083 12.8 0.2 2.2 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain RnfC_N PF13375.6 CDL01106.1 - 0.022 14.7 0.2 0.17 11.8 0.0 2.4 3 0 0 3 3 3 0 RnfC Barrel sandwich hybrid domain AAA_19 PF13245.6 CDL01106.1 - 0.032 14.6 0.5 0.081 13.3 0.5 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDL01106.1 - 0.14 11.5 2.7 0.48 9.7 0.8 2.4 3 0 0 3 3 3 0 KaiC TrwB_AAD_bind PF10412.9 CDL01106.1 - 0.24 10.3 0.3 0.4 9.5 0.3 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain ATP-synt_DE_N PF02823.16 CDL01107.1 - 1.7e-25 88.7 0.4 2.2e-25 88.3 0.4 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain FA_desaturase_2 PF03405.14 CDL01108.1 - 7.7e-07 28.3 0.0 0.0043 15.9 0.0 2.3 2 0 0 2 2 2 2 Fatty acid desaturase Rubrerythrin PF02915.17 CDL01108.1 - 0.0003 21.2 0.0 0.001 19.5 0.0 1.9 2 0 0 2 2 2 1 Rubrerythrin COQ7 PF03232.13 CDL01108.1 - 0.0059 16.4 0.0 0.25 11.1 0.0 2.6 2 1 0 2 2 2 1 Ubiquinone biosynthesis protein COQ7 Ferritin_2 PF13668.6 CDL01108.1 - 0.033 14.4 0.0 0.062 13.5 0.0 1.5 1 0 0 1 1 1 0 Ferritin-like domain DUF72 PF01904.18 CDL01108.1 - 0.065 13.3 0.6 0.16 12.0 0.6 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF72 Acyltransferase PF01553.21 CDL01109.1 - 2.2e-15 56.5 0.0 3e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase DUF218 PF02698.17 CDL01110.1 - 4.6e-14 52.6 0.0 5.7e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain FtsX PF02687.21 CDL01111.1 - 0.0014 19.0 2.2 0.0014 19.0 2.2 3.0 3 0 0 3 3 3 1 FtsX-like permease family DUF296 PF03479.15 CDL01111.1 - 0.04 14.3 0.0 0.086 13.2 0.0 1.5 1 0 0 1 1 1 0 Plants and Prokaryotes Conserved (PCC) domain ABC_tran PF00005.27 CDL01112.1 - 3.2e-30 105.4 0.0 4.1e-30 105.1 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDL01112.1 - 5e-07 29.8 0.0 0.0042 16.9 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDL01112.1 - 0.0024 17.3 0.0 0.023 14.1 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDL01112.1 - 0.0025 17.5 0.1 0.0075 16.0 0.0 1.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDL01112.1 - 0.007 16.8 0.0 0.01 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain TrwB_AAD_bind PF10412.9 CDL01112.1 - 0.0086 15.0 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA_25 PF13481.6 CDL01112.1 - 0.014 15.0 0.7 0.029 14.0 0.1 1.8 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDL01112.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 CDL01112.1 - 0.023 14.6 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_10 PF12846.7 CDL01112.1 - 0.076 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_33 PF13671.6 CDL01112.1 - 0.12 12.5 0.0 0.31 11.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain PIF1 PF05970.14 CDL01112.1 - 0.17 11.0 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase DUF87 PF01935.17 CDL01112.1 - 0.17 11.9 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain DUF3426 PF11906.8 CDL01113.1 - 2.6e-19 69.8 0.0 5.2e-19 68.9 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3426) zinc_ribbon_4 PF13717.6 CDL01113.1 - 1.1e-13 50.9 0.7 1.7e-13 50.2 0.7 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_5 PF13719.6 CDL01113.1 - 2.7e-07 30.2 0.6 4.5e-07 29.5 0.6 1.3 1 0 0 1 1 1 1 zinc-ribbon domain Trypan_PARP PF05887.11 CDL01113.1 - 0.14 12.2 5.5 0.061 13.3 2.5 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) zf-ribbon_3 PF13248.6 CDL01113.1 - 0.33 10.4 1.7 2.2 7.8 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain TFIIS_C PF01096.18 CDL01113.1 - 0.57 10.1 2.5 0.44 10.4 0.3 1.8 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Neisseria_TspB PF05616.13 CDL01113.1 - 2.3 6.6 7.6 3 6.2 7.6 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein UPF0547 PF10571.9 CDL01113.1 - 6.3 7.0 6.6 2.5 8.3 0.3 2.7 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 GGDEF PF00990.21 CDL01115.1 - 3.3e-41 140.7 0.5 5.9e-41 139.9 0.1 1.6 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain Response_reg PF00072.24 CDL01115.1 - 1.3e-30 105.8 0.0 5.1e-22 78.2 0.0 2.5 2 1 0 2 2 2 2 Response regulator receiver domain CysG_dimeriser PF10414.9 CDL01115.1 - 0.041 13.6 0.1 0.19 11.5 0.1 2.1 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region DUF2204 PF09970.9 CDL01115.1 - 0.061 13.0 0.0 0.26 10.9 0.0 2.0 2 0 0 2 2 2 0 Nucleotidyl transferase of unknown function (DUF2204) NrfD PF03916.14 CDL01116.1 - 1.1e-49 169.7 28.8 2.1e-49 168.9 28.8 1.4 1 0 0 1 1 1 1 Polysulphide reductase, NrfD DUF543 PF04418.12 CDL01116.1 - 3.1 7.9 5.2 5 7.2 0.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF543) Fer4_11 PF13247.6 CDL01117.1 - 3e-17 62.6 21.7 1.1e-16 60.8 16.6 3.0 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDL01117.1 - 1.2e-12 48.2 29.2 2.2e-06 28.2 9.1 2.7 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDL01117.1 - 2.1e-09 37.1 40.1 5.1e-06 26.3 2.7 5.0 5 0 0 5 5 5 3 4Fe-4S binding domain Fer4_10 PF13237.6 CDL01117.1 - 9.5e-09 35.2 31.7 4.7e-06 26.6 12.1 2.8 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDL01117.1 - 2.6e-07 30.7 30.6 0.0039 17.3 12.7 3.4 2 2 1 3 3 3 3 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDL01117.1 - 3e-06 27.0 36.3 0.00043 20.2 1.5 4.8 4 1 0 4 4 3 3 4Fe-4S binding domain Fer4 PF00037.27 CDL01117.1 - 5.3e-06 26.0 1.4 5.3e-06 26.0 1.4 5.7 6 1 0 6 6 5 3 4Fe-4S binding domain Fer4_21 PF14697.6 CDL01117.1 - 9.8e-06 25.6 26.2 5.3e-05 23.3 5.4 3.9 3 1 0 3 3 3 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDL01117.1 - 8e-05 23.3 43.8 0.062 14.3 7.1 4.8 4 1 0 4 4 4 3 4Fe-4S binding domain TAT_signal PF10518.9 CDL01117.1 - 0.0019 17.9 1.3 0.0019 17.9 1.3 1.8 2 0 0 2 2 2 1 TAT (twin-arginine translocation) pathway signal sequence Fer4_8 PF13183.6 CDL01117.1 - 0.024 15.1 28.2 0.55 10.7 7.5 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 CDL01117.1 - 0.036 14.6 2.5 0.036 14.6 2.5 4.8 4 1 0 4 4 3 0 4Fe-4S binding domain Fer4_16 PF13484.6 CDL01117.1 - 0.043 14.8 31.1 1.3 10.1 2.6 4.5 3 1 0 3 3 3 0 4Fe-4S double cluster binding domain Fer4_15 PF13459.6 CDL01117.1 - 0.055 14.2 0.2 0.055 14.2 0.2 3.8 4 1 0 4 4 4 0 4Fe-4S single cluster domain Fer4_17 PF13534.6 CDL01117.1 - 0.1 13.2 27.6 0.7 10.5 6.4 3.6 2 2 2 4 4 4 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDL01117.1 - 9.9 6.4 26.5 1.1 9.5 8.9 3.4 1 1 2 3 3 3 0 4Fe-4S dicluster domain Paired_CXXCH_1 PF09699.10 CDL01118.1 - 0.0003 20.5 14.4 0.00032 20.4 4.3 2.5 2 1 1 3 3 3 2 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrom_c3_2 PF14537.6 CDL01118.1 - 0.02 15.4 12.3 0.024 15.1 6.0 2.2 1 1 1 2 2 2 0 Cytochrome c3 zf-CHY PF05495.12 CDL01118.1 - 0.22 12.1 6.8 0.19 12.2 6.0 1.4 1 1 0 1 1 1 0 CHY zinc finger Cytochrome_C7 PF14522.6 CDL01118.1 - 0.27 11.3 13.5 6.2 6.9 13.5 2.3 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c Cytochrome_CBB3 PF13442.6 CDL01118.1 - 0.49 10.8 15.1 3.3 8.1 1.2 3.3 1 1 2 3 3 3 0 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_CIII PF02085.16 CDL01118.1 - 0.82 10.0 12.8 17 5.8 12.8 2.3 1 1 0 1 1 1 0 Class III cytochrome C family MCR PF18509.1 CDL01118.1 - 3.5 7.3 15.1 2.7 7.6 0.1 3.7 4 0 0 4 4 4 0 Magnetochrome domain Cytochrome_P460 PF16694.5 CDL01118.1 - 3.8 7.9 13.3 1.9 8.9 0.6 3.1 1 1 2 3 3 3 0 Cytochrome P460 Pyr_redox_2 PF07992.14 CDL01119.1 - 1.1e-23 83.9 0.6 2.5e-23 82.7 0.6 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 CDL01119.1 - 2.4e-17 62.7 13.0 1.8e-13 50.2 0.0 3.0 2 1 0 2 2 2 2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 CDL01119.1 - 9.2e-10 38.6 1.1 1.5e-09 37.9 0.1 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CDL01119.1 - 6.9e-09 36.2 6.4 0.00058 20.4 0.2 3.6 3 1 1 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_21 PF14697.6 CDL01119.1 - 1.5e-08 34.6 14.3 1.2e-07 31.7 14.3 2.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 CDL01119.1 - 7.6e-08 31.9 2.9 7.6e-08 31.9 2.9 4.1 3 1 1 4 4 3 2 4Fe-4S binding domain DAO PF01266.24 CDL01119.1 - 9.2e-08 32.0 0.4 2e-07 30.9 0.4 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Fer4_7 PF12838.7 CDL01119.1 - 9.6e-07 29.3 17.5 9.6e-07 29.3 17.5 3.4 3 1 1 4 4 3 1 4Fe-4S dicluster domain HI0933_like PF03486.14 CDL01119.1 - 1.5e-06 27.2 0.2 2.4e-06 26.5 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein Fer4_9 PF13187.6 CDL01119.1 - 2.7e-06 27.5 14.3 2.7e-06 27.5 14.3 3.8 2 2 2 4 4 4 1 4Fe-4S dicluster domain Thi4 PF01946.17 CDL01119.1 - 5.5e-06 25.8 0.6 1.1e-05 24.8 0.1 1.7 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 CDL01119.1 - 1.2e-05 24.6 0.1 2.1e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CDL01119.1 - 1.3e-05 24.8 0.4 1.3e-05 24.8 0.4 1.6 2 0 0 2 2 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CDL01119.1 - 1.7e-05 24.2 1.2 0.0032 16.8 0.3 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CDL01119.1 - 3.7e-05 23.1 0.1 7.5e-05 22.1 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 CDL01119.1 - 4.4e-05 22.8 0.5 4.4e-05 22.8 0.5 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A Fer4_10 PF13237.6 CDL01119.1 - 4.4e-05 23.5 16.2 4.4e-05 23.5 16.2 3.4 3 1 0 3 3 2 1 4Fe-4S dicluster domain Amino_oxidase PF01593.24 CDL01119.1 - 6.9e-05 22.3 0.4 0.00021 20.7 0.0 1.9 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Fer4_2 PF12797.7 CDL01119.1 - 0.00035 20.5 3.1 0.00035 20.5 3.1 4.4 4 1 0 4 4 2 1 4Fe-4S binding domain Fer4_6 PF12837.7 CDL01119.1 - 0.00064 19.7 2.5 0.00064 19.7 2.5 4.0 3 1 0 3 3 1 1 4Fe-4S binding domain Lycopene_cycl PF05834.12 CDL01119.1 - 0.0013 17.9 0.2 0.0025 16.9 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Fer4_16 PF13484.6 CDL01119.1 - 0.01 16.7 20.0 0.024 15.6 3.0 3.6 2 1 2 4 4 3 0 4Fe-4S double cluster binding domain NAD_binding_7 PF13241.6 CDL01119.1 - 0.015 15.7 1.4 0.21 12.0 0.1 3.1 3 1 0 3 3 3 0 Putative NAD(P)-binding FMO-like PF00743.19 CDL01119.1 - 0.015 13.7 0.0 0.28 9.5 0.0 2.0 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like AlaDh_PNT_C PF01262.21 CDL01119.1 - 0.039 13.2 8.7 0.049 12.9 1.4 2.4 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Fer4_18 PF13746.6 CDL01119.1 - 0.047 13.9 14.5 0.085 13.1 1.4 3.2 2 1 1 3 3 3 0 4Fe-4S dicluster domain NAD_binding_9 PF13454.6 CDL01119.1 - 0.059 13.4 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Fer4_8 PF13183.6 CDL01119.1 - 0.071 13.6 20.3 0.032 14.7 15.1 2.8 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_15 PF13459.6 CDL01119.1 - 0.49 11.2 10.7 0.23 12.2 1.0 3.2 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_17 PF13534.6 CDL01119.1 - 0.72 10.4 23.2 0.031 14.8 14.4 3.2 3 1 1 4 4 3 0 4Fe-4S dicluster domain Trp_halogenase PF04820.14 CDL01119.1 - 1.5 7.5 2.9 0.78 8.5 0.3 1.8 2 0 0 2 2 2 0 Tryptophan halogenase Fer4_13 PF13370.6 CDL01119.1 - 3.8 8.1 16.6 0.19 12.3 2.0 3.1 2 1 1 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_17 PF13534.6 CDL01120.1 - 2e-09 37.9 1.0 7.8e-09 35.9 1.0 2.1 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDL01120.1 - 6.7e-09 36.1 1.4 6.7e-09 36.1 1.4 1.9 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDL01120.1 - 2.7e-06 27.4 1.4 0.029 14.5 0.1 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDL01120.1 - 2.4e-05 24.9 4.0 0.00032 21.2 4.4 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDL01120.1 - 0.00081 19.5 10.4 0.082 13.1 12.0 2.5 1 1 2 3 3 3 3 4Fe-4S dicluster domain CCG PF02754.16 CDL01120.1 - 0.0011 19.1 0.6 0.004 17.3 0.3 2.2 2 0 0 2 2 2 1 Cysteine-rich domain Fer4_2 PF12797.7 CDL01120.1 - 0.0013 18.7 9.0 0.25 11.5 1.5 2.7 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4 PF00037.27 CDL01120.1 - 0.0016 18.2 11.6 0.18 11.7 4.0 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 CDL01120.1 - 0.0021 18.1 10.6 0.26 11.5 1.5 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CDL01120.1 - 0.0098 16.3 11.5 0.52 11.0 1.9 2.7 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 CDL01120.1 - 0.016 16.1 8.4 0.42 11.6 0.2 2.9 3 0 0 3 3 3 0 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 CDL01120.1 - 0.046 13.8 4.8 3.9 7.7 0.3 2.6 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDL01120.1 - 0.24 11.6 6.1 1.8 8.8 0.1 2.9 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_22 PF17179.4 CDL01120.1 - 0.4 11.6 7.1 7.8 7.4 0.6 3.1 3 0 0 3 3 3 0 4Fe-4S dicluster domain Nitrate_red_gam PF02665.14 CDL01121.1 - 3.5e-14 52.9 12.5 3.5e-14 52.9 12.5 2.6 2 1 0 2 2 2 1 Nitrate reductase gamma subunit DsrC PF04358.13 CDL01122.1 - 4.2e-47 159.1 0.0 4.6e-47 159.0 0.0 1.0 1 0 0 1 1 1 1 DsrC like protein DsrH PF04077.12 CDL01123.1 - 3.9e-30 103.8 0.0 4.3e-30 103.7 0.0 1.0 1 0 0 1 1 1 1 DsrH like protein DrsE PF02635.15 CDL01123.1 - 0.0021 18.4 0.1 0.0028 18.0 0.1 1.3 1 0 0 1 1 1 1 DsrE/DsrF-like family DrsE PF02635.15 CDL01124.1 - 5.5e-26 91.2 0.0 6.1e-26 91.1 0.0 1.0 1 0 0 1 1 1 1 DsrE/DsrF-like family DrsE PF02635.15 CDL01125.1 - 3.9e-33 114.3 0.0 4.3e-33 114.2 0.0 1.0 1 0 0 1 1 1 1 DsrE/DsrF-like family NIR_SIR PF01077.22 CDL01126.1 - 1.5e-25 89.6 0.0 2e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 CDL01126.1 - 3.3e-11 42.8 0.0 1.5e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 Nitrite/Sulfite reductase ferredoxin-like half domain Fer4_9 PF13187.6 CDL01126.1 - 1.6 8.9 12.7 0.072 13.3 7.0 1.7 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDL01126.1 - 4.4 7.5 15.8 0.71 10.1 9.3 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4 PF00037.27 CDL01126.1 - 4.8 7.2 14.1 2.9 7.9 8.6 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_7 PF12838.7 CDL01126.1 - 7.4 7.2 13.9 21 5.8 13.9 1.9 1 1 0 1 1 1 0 4Fe-4S dicluster domain NIR_SIR PF01077.22 CDL01127.1 - 2.8e-34 117.9 0.0 3.9e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 CDL01127.1 - 8.2e-07 28.8 0.0 2e-06 27.5 0.0 1.7 2 0 0 2 2 2 1 Nitrite/Sulfite reductase ferredoxin-like half domain Fer4_7 PF12838.7 CDL01127.1 - 0.0044 17.6 2.1 0.0044 17.6 2.1 2.6 2 1 1 3 3 3 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDL01127.1 - 0.013 15.7 2.3 0.013 15.7 2.3 2.6 2 1 1 3 3 3 0 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDL01127.1 - 0.036 14.2 0.8 0.036 14.2 0.8 2.7 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDL01127.1 - 0.045 13.9 12.2 0.18 11.9 3.3 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 CDL01127.1 - 0.22 12.1 3.4 0.33 11.5 0.0 2.8 3 0 0 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 CDL01127.1 - 0.43 11.5 4.7 9.1 7.2 0.3 2.6 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDL01127.1 - 0.9 10.0 10.0 7.6 7.1 9.5 2.4 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDL01127.1 - 6.1 7.5 9.3 7.6 7.2 0.9 2.7 3 0 0 3 3 3 0 4Fe-4S dicluster domain TauD PF02668.16 CDL01128.1 - 4.5e-17 62.7 0.0 5e-17 62.6 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 CDL01128.1 - 0.15 11.2 0.0 0.32 10.1 0.0 1.5 2 0 0 2 2 2 0 CsiD DUF4698 PF15769.5 CDL01130.1 - 0.045 12.8 0.6 0.059 12.4 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) DUF2203 PF09969.9 CDL01130.1 - 0.97 10.2 4.2 4.3 8.1 1.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) CENP-H PF05837.12 CDL01130.1 - 1.6 9.1 6.2 0.52 10.7 1.3 2.2 1 1 0 2 2 2 0 Centromere protein H (CENP-H) HisKA_3 PF07730.13 CDL01130.1 - 3.1 8.4 15.4 24 5.5 8.3 3.3 2 1 0 2 2 2 0 Histidine kinase DUF948 PF06103.11 CDL01130.1 - 3.6 7.9 8.5 5.9 7.2 1.3 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Phasin_2 PF09361.10 CDL01130.1 - 4 7.8 20.9 0.49 10.7 9.7 2.4 1 1 2 3 3 3 0 Phasin protein Helicase_C PF00271.31 CDL01131.1 - 1.9e-08 34.6 0.0 4e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF5131 PF07505.11 CDL01131.1 - 0.0026 17.3 0.2 0.29 10.5 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF5131) IstB_IS21 PF01695.17 CDL01131.1 - 0.13 12.0 0.5 4.3 7.0 0.1 2.7 2 1 1 3 3 3 0 IstB-like ATP binding protein PTPS PF01242.19 CDL01132.1 - 1.6e-34 118.5 0.4 2.8e-33 114.5 0.4 2.0 1 1 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase Radical_SAM PF04055.21 CDL01133.1 - 0.00019 21.9 0.0 0.00026 21.4 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 CDL01133.1 - 0.01 16.0 0.3 0.057 13.5 0.3 2.2 1 1 0 1 1 1 0 4Fe-4S single cluster domain Fer4_12 PF13353.6 CDL01133.1 - 0.055 13.7 0.0 0.096 12.9 0.0 1.4 1 1 0 1 1 1 0 4Fe-4S single cluster domain Methyltrans_RNA PF04452.14 CDL01135.1 - 2.4e-56 190.6 0.0 2.7e-56 190.4 0.0 1.0 1 0 0 1 1 1 1 RNA methyltransferase NfeD PF01957.18 CDL01136.1 - 1.2e-14 54.4 0.0 1.8e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 NfeD-like C-terminal, partner-binding Band_7 PF01145.25 CDL01137.1 - 1.8e-32 112.8 1.7 1.8e-32 112.8 1.7 2.3 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 CDL01137.1 - 8.7e-05 22.5 3.5 0.00018 21.5 3.5 1.6 1 0 0 1 1 1 1 C-terminal region of band_7 DUF3382 PF11862.8 CDL01137.1 - 0.0023 18.2 0.5 0.0067 16.7 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3382) Band_7_1 PF13421.6 CDL01137.1 - 0.013 15.3 0.2 0.021 14.5 0.2 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family LON_substr_bdg PF02190.16 CDL01137.1 - 0.061 13.2 0.1 0.15 11.9 0.0 1.7 2 0 0 2 2 2 0 ATP-dependent protease La (LON) substrate-binding domain NAD_Gly3P_dh_N PF01210.23 CDL01138.1 - 7.1e-46 156.0 0.0 1.1e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 CDL01138.1 - 5e-45 153.3 0.5 7.4e-45 152.7 0.5 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus ApbA PF02558.16 CDL01138.1 - 3.7e-08 33.1 0.0 5.8e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 CDL01138.1 - 6.5e-07 29.9 0.0 1.5e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CDL01138.1 - 0.00018 21.7 0.0 0.00042 20.5 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Rossmann-like PF10727.9 CDL01138.1 - 0.00087 19.2 0.2 0.0027 17.6 0.2 1.9 1 0 0 1 1 1 1 Rossmann-like domain NAD_binding_8 PF13450.6 CDL01138.1 - 0.0023 18.1 0.0 0.0048 17.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ApbA_C PF08546.11 CDL01138.1 - 0.007 16.6 0.3 0.02 15.1 0.0 1.9 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal 2-Hacid_dh_C PF02826.19 CDL01138.1 - 0.011 15.2 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CDL01138.1 - 0.026 14.4 1.0 0.081 12.8 1.0 1.8 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 CDL01138.1 - 0.05 12.8 0.3 0.15 11.2 0.0 1.9 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CDL01138.1 - 0.051 13.8 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain GFO_IDH_MocA PF01408.22 CDL01138.1 - 0.087 13.6 0.0 0.16 12.8 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold GIDA PF01134.22 CDL01138.1 - 0.15 11.1 0.2 0.21 10.6 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A YCII PF03795.14 CDL01139.1 - 8.6e-18 64.5 0.0 1e-17 64.3 0.0 1.0 1 0 0 1 1 1 1 YCII-related domain EVE PF01878.18 CDL01140.1 - 1.2e-47 161.6 0.0 1.3e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 EVE domain 3HCDH_N PF02737.18 CDL01140.1 - 0.23 11.3 0.0 0.32 10.9 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Rieske PF00355.26 CDL01141.1 - 7.9e-11 41.8 0.0 8.3e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain AMP-binding PF00501.28 CDL01142.1 - 1.4e-94 317.1 0.1 1.8e-94 316.8 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDL01142.1 - 6.1e-26 91.2 0.3 2.6e-25 89.2 0.1 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 CDL01142.1 - 2.5e-20 72.1 0.8 6.1e-20 70.9 0.8 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Hydrolase_4 PF12146.8 CDL01143.1 - 7.5e-16 58.1 0.5 1e-09 38.0 0.2 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDL01143.1 - 5.6e-10 39.3 0.2 0.00061 19.5 0.3 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDL01143.1 - 9.9e-05 23.0 9.4 0.018 15.7 3.9 2.4 1 1 1 2 2 2 2 Alpha/beta hydrolase family AXE1 PF05448.12 CDL01143.1 - 0.0002 20.2 0.5 0.0019 16.9 0.1 2.1 1 1 1 2 2 2 1 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.18 CDL01143.1 - 0.00031 20.4 0.3 0.044 13.4 0.2 2.3 1 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 CDL01143.1 - 0.00067 19.5 0.0 0.1 12.4 0.0 2.8 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase BAAT_C PF08840.11 CDL01143.1 - 0.0014 18.6 0.0 0.76 9.7 0.0 2.2 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 CDL01143.1 - 0.0035 17.2 1.1 0.006 16.5 0.9 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 CDL01143.1 - 0.01 15.6 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family DLH PF01738.18 CDL01143.1 - 0.012 15.2 0.1 0.063 12.8 0.1 2.2 1 1 1 2 2 2 0 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CDL01143.1 - 0.019 14.5 1.3 0.21 11.1 0.0 2.5 2 1 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_4 PF08386.10 CDL01143.1 - 0.044 13.9 0.0 0.078 13.1 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein FSH1 PF03959.13 CDL01143.1 - 0.065 12.9 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) PAS_7 PF12860.7 CDL01144.1 - 5.2e-78 258.7 0.0 6.2e-37 126.3 0.0 4.8 4 1 1 5 5 5 3 PAS fold GGDEF PF00990.21 CDL01144.1 - 4.6e-46 156.5 0.6 1.2e-45 155.2 0.1 1.9 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain PAS PF00989.25 CDL01144.1 - 1.7e-23 82.8 0.1 6.2e-08 32.6 0.0 5.0 5 1 0 5 5 5 4 PAS fold PAS_8 PF13188.7 CDL01144.1 - 8e-18 64.0 0.1 7.8e-06 25.8 0.0 4.2 3 0 0 3 3 3 3 PAS domain PAS_9 PF13426.7 CDL01144.1 - 9.8e-14 51.5 0.0 0.00041 20.5 0.0 5.2 5 0 0 5 5 5 3 PAS domain PAS_4 PF08448.10 CDL01144.1 - 5e-13 49.3 2.4 0.00068 19.9 0.0 6.0 5 1 0 5 5 5 3 PAS fold MLTR_LBD PF17765.1 CDL01144.1 - 1.6e-05 25.1 2.6 0.0094 16.1 0.0 4.0 4 0 0 4 4 4 1 MmyB-like transcription regulator ligand binding domain Mg_chelatase_C PF13335.6 CDL01144.1 - 0.078 13.6 0.3 0.88 10.2 0.0 2.8 3 1 0 3 3 3 0 Magnesium chelatase, subunit ChlI C-terminal PAS_10 PF13596.6 CDL01144.1 - 0.16 12.6 0.0 27 5.4 0.0 3.8 4 0 0 4 4 4 0 PAS domain Aminotran_1_2 PF00155.21 CDL01145.1 - 6e-76 256.0 0.0 6.8e-76 255.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CDL01145.1 - 1.9e-06 27.5 0.0 2.7e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family LpxI_C PF06230.11 CDL01145.1 - 0.037 13.9 0.3 0.077 12.9 0.1 1.6 2 0 0 2 2 2 0 LpxI C-terminal domain Cys_Met_Meta_PP PF01053.20 CDL01145.1 - 0.071 11.6 0.0 0.12 10.9 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme ALF PF03752.13 CDL01145.1 - 0.26 11.3 2.2 21 5.2 0.1 2.8 2 0 0 2 2 2 0 Short repeats of unknown function Phasin_2 PF09361.10 CDL01147.1 - 4.9e-21 74.9 4.7 7.5e-21 74.3 4.7 1.3 1 0 0 1 1 1 1 Phasin protein FtsJ PF01728.19 CDL01147.1 - 0.016 15.3 0.1 0.019 15.1 0.1 1.1 1 0 0 1 1 1 0 FtsJ-like methyltransferase MIF4G_like_2 PF09090.11 CDL01147.1 - 0.056 12.9 3.1 0.064 12.7 3.1 1.2 1 0 0 1 1 1 0 MIF4G like Chlorosome_CsmC PF11098.8 CDL01147.1 - 0.079 12.9 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Chlorosome envelope protein C DUF2935 PF11155.8 CDL01147.1 - 0.085 13.2 2.9 0.11 12.8 2.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) AP_endonuc_2 PF01261.24 CDL01147.1 - 0.17 11.3 0.3 0.23 10.9 0.3 1.3 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel PPE PF00823.19 CDL01147.1 - 0.18 11.9 1.3 0.48 10.5 0.9 1.8 1 1 1 2 2 2 0 PPE family HisKA_3 PF07730.13 CDL01147.1 - 0.23 12.0 4.4 2.6 8.6 2.3 2.9 1 1 1 2 2 2 0 Histidine kinase DUF883 PF05957.13 CDL01147.1 - 0.76 10.4 4.5 1.1 9.9 0.5 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) ABC_tran PF00005.27 CDL01148.1 - 3.5e-30 105.3 0.0 6e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDL01148.1 - 2.6e-11 43.9 2.3 1.9e-05 24.6 0.0 2.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CDL01148.1 - 0.00011 21.9 0.2 0.0027 17.3 0.2 2.5 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 CDL01148.1 - 0.00031 20.2 0.1 0.13 11.7 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDL01148.1 - 0.00043 20.0 0.1 0.00081 19.1 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF4162 PF13732.6 CDL01148.1 - 0.0011 19.6 0.0 0.002 18.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_23 PF13476.6 CDL01148.1 - 0.002 18.6 0.0 0.0037 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDL01148.1 - 0.015 15.7 0.9 0.055 13.8 0.9 2.3 1 1 0 1 1 1 0 AAA ATPase domain NAC PF01849.18 CDL01148.1 - 0.017 15.1 0.1 0.065 13.2 0.0 2.0 2 0 0 2 2 2 0 NAC domain T2SSE PF00437.20 CDL01148.1 - 0.036 13.1 0.0 0.068 12.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Rad17 PF03215.15 CDL01148.1 - 0.078 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 CDL01148.1 - 0.078 12.9 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 CDL01148.1 - 0.086 12.5 0.0 0.43 10.2 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 CDL01148.1 - 0.11 12.7 0.1 0.4 10.8 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_27 PF13514.6 CDL01148.1 - 0.11 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 CDL01148.1 - 0.11 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA PF00004.29 CDL01148.1 - 0.12 12.8 0.0 0.5 10.8 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDL01148.1 - 0.15 12.4 0.2 1.2 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC2_membrane PF01061.24 CDL01149.1 - 2.8e-30 105.3 27.0 4.1e-30 104.8 27.0 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CDL01149.1 - 2.9e-16 59.5 31.1 3.8e-16 59.1 31.1 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 CDL01149.1 - 1.4e-08 34.4 22.9 2e-08 33.9 22.9 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 CDL01149.1 - 0.0076 16.2 16.7 0.055 13.4 16.7 2.0 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_5 PF13346.6 CDL01149.1 - 0.059 12.9 14.3 0.1 12.2 14.3 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein Titin_Ig-rpts PF06582.12 CDL01149.1 - 0.25 11.3 0.0 0.4 10.6 0.0 1.3 1 0 0 1 1 1 0 Titin repeat GreA_GreB PF01272.19 CDL01150.1 - 2e-24 85.3 0.2 4e-24 84.3 0.0 1.5 2 0 0 2 2 2 1 Transcription elongation factor, GreA/GreB, C-term GreA_GreB_N PF03449.15 CDL01150.1 - 3.1e-22 78.5 0.0 4.8e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 Transcription elongation factor, N-terminal Aminotran_4 PF01063.19 CDL01151.1 - 5e-54 183.5 0.0 6.2e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV Chorismate_bind PF00425.18 CDL01152.1 - 2.7e-95 318.8 0.0 3.2e-95 318.6 0.0 1.1 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 CDL01152.1 - 2.1e-17 63.7 0.0 4.7e-16 59.3 0.0 2.5 2 1 0 2 2 2 1 Anthranilate synthase component I, N terminal region 2-Hacid_dh_C PF02826.19 CDL01153.1 - 1.3e-59 200.6 0.1 3.2e-59 199.3 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDL01153.1 - 8.3e-31 106.4 0.0 9.4e-31 106.2 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CDL01153.1 - 1.1e-06 28.9 0.0 2e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CDL01153.1 - 0.00031 20.3 0.0 0.038 13.6 0.0 2.3 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 CDL01153.1 - 0.00052 20.6 0.0 0.0044 17.6 0.0 2.5 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 CDL01153.1 - 0.013 16.4 0.0 0.032 15.1 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold XdhC_C PF13478.6 CDL01153.1 - 0.11 13.1 0.2 0.43 11.1 0.0 2.0 2 1 0 2 2 2 0 XdhC Rossmann domain Shikimate_DH PF01488.20 CDL01153.1 - 0.13 12.4 0.0 0.4 10.7 0.0 1.8 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase SH3_4 PF06347.13 CDL01154.1 - 4e-25 87.4 1.7 6.1e-18 64.4 0.5 2.4 2 0 0 2 2 2 2 Bacterial SH3 domain SH3_3 PF08239.11 CDL01154.1 - 4e-06 27.0 0.1 0.0058 16.9 1.1 3.0 2 1 0 2 2 2 2 Bacterial SH3 domain PAP2 PF01569.21 CDL01155.1 - 1.1e-23 83.5 8.1 2.6e-23 82.3 8.1 1.6 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 CDL01155.1 - 3.7e-05 23.5 13.9 0.00013 21.7 13.9 2.0 1 1 0 1 1 1 1 PAP2 superfamily PMT_2 PF13231.6 CDL01156.1 - 1.6e-10 41.5 0.5 1.6e-10 41.5 0.5 4.8 4 1 2 6 6 6 2 Dolichyl-phosphate-mannose-protein mannosyltransferase ABC2_membrane_5 PF13346.6 CDL01156.1 - 1.6 8.3 5.5 0.99 8.9 2.6 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein 3HCDH_N PF02737.18 CDL01157.1 - 1.2e-63 214.2 0.1 1.5e-63 213.9 0.1 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CDL01157.1 - 1.4e-34 118.6 0.0 4.7e-34 116.9 0.0 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CDL01157.1 - 9.8e-06 25.8 0.5 2.1e-05 24.7 0.5 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CDL01157.1 - 0.00072 19.0 0.5 0.0017 17.8 0.4 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CDL01157.1 - 0.00078 19.1 0.1 0.0011 18.6 0.1 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain F420_oxidored PF03807.17 CDL01157.1 - 0.0051 17.4 1.8 0.0093 16.5 1.8 1.6 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 CDL01157.1 - 0.02 15.1 0.2 0.038 14.2 0.2 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_Gly3P_dh_N PF01210.23 CDL01157.1 - 0.025 14.6 0.0 0.071 13.1 0.0 1.8 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus adh_short_C2 PF13561.6 CDL01157.1 - 0.039 13.5 0.4 0.053 13.1 0.4 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase ApbA PF02558.16 CDL01157.1 - 0.069 12.8 0.2 0.25 11.0 0.1 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA XdhC_C PF13478.6 CDL01157.1 - 0.075 13.5 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 XdhC Rossmann domain AlaDh_PNT_C PF01262.21 CDL01157.1 - 0.077 12.3 0.7 0.24 10.7 0.5 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ETF PF01012.21 CDL01158.1 - 2.3e-36 125.4 13.4 3.8e-36 124.7 13.4 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 CDL01158.1 - 4.9e-36 122.6 0.3 4.9e-36 122.6 0.3 3.0 2 1 1 3 3 3 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.21 CDL01159.1 - 2.5e-47 161.1 1.5 3.1e-47 160.8 1.5 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Cob_adeno_trans PF01923.18 CDL01160.1 - 4.5e-61 205.8 0.0 5.1e-61 205.6 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase LptF_LptG PF03739.14 CDL01161.1 - 1.5e-59 201.6 8.8 1.8e-59 201.4 8.8 1.0 1 0 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG PMT_2 PF13231.6 CDL01162.1 - 8.1e-33 113.9 14.7 8.1e-33 113.9 14.7 2.9 3 0 0 3 3 3 2 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT PF02366.18 CDL01162.1 - 1.7e-07 31.1 12.3 1.7e-07 31.1 12.3 2.3 1 1 1 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PAP2 PF01569.21 CDL01163.1 - 1.5e-17 63.7 1.6 1.5e-17 63.7 1.6 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 CDL01163.1 - 2.1e-06 27.5 0.5 2.1e-06 27.5 0.5 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 CDL01163.1 - 0.14 12.7 0.3 0.14 12.7 0.3 1.9 2 0 0 2 2 2 0 PAP2 superfamily C-terminal CSD PF00313.22 CDL01164.1 - 1.4e-37 127.4 1.6 1.8e-20 72.5 0.8 2.1 2 0 0 2 2 2 2 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CDL01164.1 - 1.2e-09 37.7 0.6 0.00012 21.7 0.3 2.5 2 0 0 2 2 2 2 Ribonuclease B OB domain IalB PF06776.12 CDL01165.1 - 3.9e-05 23.7 0.0 6.2e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 Invasion associated locus B (IalB) protein OMP_b-brl PF13505.6 CDL01166.1 - 6.5e-20 72.0 13.9 8.1e-20 71.7 13.9 1.0 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain Surface_Ag_2 PF01617.17 CDL01166.1 - 2.7e-08 33.6 0.3 1.8e-05 24.3 0.0 2.3 1 1 0 2 2 2 2 Surface antigen OmpA_membrane PF01389.17 CDL01166.1 - 6.2e-08 32.6 5.5 7.8e-08 32.3 5.5 1.1 1 0 0 1 1 1 1 OmpA-like transmembrane domain Opacity PF02462.15 CDL01166.1 - 7.3e-08 32.6 1.1 2e-07 31.2 0.4 1.9 1 1 1 2 2 2 1 Opacity family porin protein PagL PF09411.10 CDL01166.1 - 2e-07 31.2 3.4 0.00024 21.3 0.5 2.2 1 1 1 2 2 2 2 Lipid A 3-O-deacylase (PagL) OmpW PF03922.14 CDL01166.1 - 0.00012 22.0 0.3 0.00017 21.5 0.3 1.3 1 0 0 1 1 1 1 OmpW family OMP_b-brl_2 PF13568.6 CDL01166.1 - 0.02 14.9 2.9 0.071 13.1 2.7 2.0 1 1 1 2 2 2 0 Outer membrane protein beta-barrel domain WD40 PF00400.32 CDL01169.1 - 4e-20 71.8 9.5 0.0064 17.3 0.0 8.3 9 0 0 9 9 9 6 WD domain, G-beta repeat Peptidase_C14 PF00656.22 CDL01169.1 - 2.6e-10 40.7 0.0 2.1e-09 37.7 0.0 2.1 2 0 0 2 2 2 1 Caspase domain ANAPC4_WD40 PF12894.7 CDL01169.1 - 1.1e-07 32.1 0.6 5.4 7.4 0.0 6.0 3 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Big_7 PF17957.1 CDL01169.1 - 0.00032 21.4 0.8 0.002 18.8 0.8 2.5 1 1 0 1 1 1 1 Bacterial Ig domain Nup160 PF11715.8 CDL01169.1 - 0.0035 16.0 0.1 0.37 9.4 0.0 2.5 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Cadherin-like PF12733.7 CDL01169.1 - 0.17 12.5 0.7 0.54 10.8 0.7 1.9 1 0 0 1 1 1 0 Cadherin-like beta sandwich domain Autotransporter PF03797.19 CDL01170.1 - 7.8e-28 97.8 13.5 1.3e-27 97.1 13.5 1.3 1 0 0 1 1 1 1 Autotransporter beta-domain OMP_b-brl PF13505.6 CDL01170.1 - 3.8e-05 23.9 16.0 0.016 15.4 0.8 2.5 1 1 1 2 2 2 2 Outer membrane protein beta-barrel domain CHASE2 PF05226.11 CDL01171.1 - 7.8e-31 107.7 1.0 6.6e-30 104.6 0.7 2.0 2 0 0 2 2 2 1 CHASE2 domain Guanylate_cyc PF00211.20 CDL01171.1 - 7.9e-28 97.3 0.0 1.3e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PQQ_2 PF13360.6 CDL01172.1 - 0.0012 18.5 0.1 0.0082 15.7 0.0 2.0 2 0 0 2 2 2 1 PQQ-like domain DUF454 PF04304.13 CDL01173.1 - 0.07 13.1 2.2 0.33 11.0 2.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF454) DUF3381 PF11861.8 CDL01173.1 - 0.13 12.1 0.0 0.16 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) MHYT PF03707.16 CDL01174.1 - 0.12 12.5 1.6 0.29 11.3 1.6 1.7 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat DDE_3 PF13358.6 CDL01175.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL01175.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDL01176.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL01176.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL01176.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL01176.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL01176.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL01176.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain UbiA PF01040.18 CDL01177.1 - 7.9e-48 162.9 31.7 1.1e-47 162.5 31.7 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF1440 PF07274.12 CDL01177.1 - 0.02 15.2 0.2 0.082 13.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1440) MtrE PF04206.12 CDL01177.1 - 1.9 7.7 6.8 0.51 9.6 0.1 2.6 1 1 2 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit E DUF420 PF04238.12 CDL01178.1 - 2e-37 128.4 10.7 2.3e-37 128.2 10.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF420) DUF2516 PF10724.9 CDL01178.1 - 0.042 14.1 0.9 0.042 14.1 0.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2516) PC_rep PF01851.22 CDL01178.1 - 0.073 13.5 0.2 0.16 12.4 0.2 1.7 1 1 0 1 1 1 0 Proteasome/cyclosome repeat MCPsignal PF00015.21 CDL01180.1 - 4.4e-30 104.8 25.7 4.4e-30 104.8 25.7 3.6 3 1 1 4 4 4 1 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDL01180.1 - 5.3e-06 26.7 0.0 5.3e-06 26.7 0.0 4.2 4 0 0 4 4 4 1 HAMP domain DUF948 PF06103.11 CDL01180.1 - 0.02 15.1 12.8 0.25 11.6 2.2 4.0 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Vps53_N PF04100.12 CDL01180.1 - 0.11 11.4 0.8 0.23 10.4 0.8 1.5 1 0 0 1 1 1 0 Vps53-like, N-terminal Lactamase_B PF00753.27 CDL01181.1 - 2.8e-24 86.2 3.0 3.4e-24 86.0 3.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDL01181.1 - 0.0037 16.8 0.0 0.0049 16.4 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lysine_decarbox PF03641.14 CDL01182.1 - 2.3e-33 115.1 0.1 4.3e-33 114.2 0.1 1.5 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 CDL01182.1 - 1.5e-08 34.3 0.0 2.8e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 SLOG cluster4 family DUF4824 PF16106.5 CDL01182.1 - 0.03 13.6 0.2 0.045 13.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4824) Cytidylate_kin2 PF13189.6 CDL01183.1 - 1e-37 130.0 0.0 1.2e-37 129.8 0.0 1.1 1 0 0 1 1 1 1 Cytidylate kinase-like family Calici_MSP PF05752.11 CDL01183.1 - 0.056 13.3 0.1 0.16 11.8 0.1 1.8 2 0 0 2 2 2 0 Calicivirus minor structural protein YbgT_YccB PF08173.11 CDL01185.1 - 1.1e-15 57.4 7.2 1.2e-15 57.3 7.2 1.0 1 0 0 1 1 1 1 Membrane bound YbgT-like protein Cyt_bd_oxida_II PF02322.15 CDL01186.1 - 1.8e-103 346.1 33.2 2.1e-103 345.8 33.2 1.0 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit II Cyt_bd_oxida_I PF01654.17 CDL01187.1 - 9.1e-177 587.9 22.4 1e-176 587.7 22.4 1.0 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit I DUF2946 PF11162.8 CDL01189.1 - 7.2e-07 29.9 2.8 9.3e-07 29.5 2.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2946) PocR PF10114.9 CDL01189.1 - 0.18 11.6 0.0 0.26 11.1 0.0 1.2 1 0 0 1 1 1 0 Sensory domain found in PocR HTH_20 PF12840.7 CDL01190.1 - 6.9e-16 58.1 0.5 1.1e-15 57.4 0.5 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 CDL01190.1 - 2.6e-07 30.4 0.0 4.9e-07 29.5 0.0 1.6 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 CDL01190.1 - 6.3e-06 26.0 0.2 1.3e-05 25.0 0.1 1.7 2 1 0 2 2 2 1 MarR family HTH_Crp_2 PF13545.6 CDL01190.1 - 0.00028 20.8 0.1 0.00062 19.7 0.1 1.6 1 1 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 CDL01190.1 - 0.00079 18.9 0.0 0.0017 17.9 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 CDL01190.1 - 0.0016 18.8 0.0 0.0026 18.1 0.0 1.4 1 1 0 1 1 1 1 Transcriptional regulator Penicillinase_R PF03965.16 CDL01190.1 - 0.0021 18.4 0.0 0.0023 18.3 0.0 1.2 1 0 0 1 1 1 1 Penicillinase repressor GerE PF00196.19 CDL01190.1 - 0.0026 17.3 0.0 0.0036 16.8 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Fe_dep_repress PF01325.19 CDL01190.1 - 0.0042 17.3 0.0 0.0093 16.1 0.0 1.5 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain HTH_11 PF08279.12 CDL01190.1 - 0.011 15.7 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 HTH domain HTH_23 PF13384.6 CDL01190.1 - 0.04 13.7 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain TrmB PF01978.19 CDL01190.1 - 0.041 13.8 0.0 0.059 13.3 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_10 PF04967.12 CDL01190.1 - 0.043 13.6 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain HTH_IclR PF09339.10 CDL01190.1 - 0.043 13.6 0.5 0.13 12.1 0.5 1.8 1 1 0 1 1 1 0 IclR helix-turn-helix domain GntR PF00392.21 CDL01190.1 - 0.048 13.3 0.5 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family RP-C PF03428.13 CDL01190.1 - 0.053 13.2 0.0 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Replication protein C N-terminal domain HTH_28 PF13518.6 CDL01190.1 - 0.071 13.2 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_40 PF14493.6 CDL01190.1 - 0.087 13.3 0.0 0.21 12.1 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_34 PF13601.6 CDL01190.1 - 0.16 12.2 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain TFIIE_alpha PF02002.17 CDL01190.1 - 0.2 11.5 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 TFIIE alpha subunit Methyltransf_31 PF13847.6 CDL01191.1 - 2.7e-34 118.2 0.0 4.1e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL01191.1 - 2e-21 76.5 0.1 5.4e-21 75.1 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL01191.1 - 3.9e-21 75.5 0.3 7.9e-21 74.5 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDL01191.1 - 5e-19 68.6 0.0 7.5e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 CDL01191.1 - 8.7e-10 38.7 0.0 1.6e-09 37.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL01191.1 - 3.4e-09 37.3 0.0 6.3e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDL01191.1 - 2.8e-08 33.8 0.1 5.3e-08 32.9 0.1 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 CDL01191.1 - 3.9e-05 23.7 0.0 6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CDL01191.1 - 9e-05 21.5 0.0 0.00016 20.7 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_8 PF05148.15 CDL01191.1 - 0.0001 22.2 0.4 0.00035 20.5 0.4 1.8 1 1 0 1 1 1 1 Hypothetical methyltransferase PrmA PF06325.13 CDL01191.1 - 0.0002 20.9 0.1 0.00028 20.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 CDL01191.1 - 0.00037 20.2 0.0 0.00058 19.6 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.14 CDL01191.1 - 0.00095 18.7 0.0 0.0017 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 CDL01191.1 - 0.0012 18.8 0.0 0.0043 17.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 CDL01191.1 - 0.019 14.3 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DOT1 PF08123.13 CDL01191.1 - 0.024 14.1 0.1 0.037 13.6 0.1 1.3 1 1 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_15 PF09445.10 CDL01191.1 - 0.065 12.8 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase FtsJ PF01728.19 CDL01191.1 - 0.12 12.5 0.1 0.2 11.7 0.1 1.3 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CDL01191.1 - 0.16 11.4 0.1 0.49 9.8 0.1 1.8 2 0 0 2 2 2 0 Putative methyltransferase DDE_3 PF13358.6 CDL01192.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL01192.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDL01193.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL01193.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL01193.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL01193.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL01193.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL01193.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain E1-E2_ATPase PF00122.20 CDL01194.1 - 1.5e-32 112.6 3.3 1.5e-32 112.6 3.3 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CDL01194.1 - 2.8e-29 102.9 1.7 2.8e-29 102.9 1.7 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDL01194.1 - 0.034 13.9 0.0 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDL01194.1 - 0.043 14.2 5.5 0.095 13.1 0.5 3.4 3 2 0 3 3 3 0 haloacid dehalogenase-like hydrolase DUF5132 PF17195.4 CDL01195.1 - 0.00098 19.2 0.4 0.0019 18.2 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF5132) HMA PF00403.26 CDL01198.1 - 1.5e-05 25.3 0.0 2.4e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Heavy-metal-associated domain DUF4405 PF14358.6 CDL01199.1 - 0.0042 17.6 0.7 0.0063 17.0 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4405) DUF3828 PF12883.7 CDL01200.1 - 0.036 14.4 0.0 0.051 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3828) RrnaAD PF00398.20 CDL01202.1 - 1.6e-49 168.4 0.0 1.8e-49 168.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 CDL01202.1 - 0.022 15.4 0.0 0.045 14.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_5 PF01795.19 CDL01202.1 - 0.094 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 MraW methylase family PdxA PF04166.12 CDL01203.1 - 2.5e-101 338.8 1.7 2.8e-101 338.6 1.7 1.0 1 0 0 1 1 1 1 Pyridoxal phosphate biosynthetic protein PdxA VPDSG-CTERM PF18205.1 CDL01203.1 - 0.078 12.8 0.3 0.23 11.3 0.3 1.9 1 0 0 1 1 1 0 VPDSG-CTERM motif Rotamase PF00639.21 CDL01204.1 - 3e-18 66.6 0.0 5.4e-15 56.1 0.0 2.6 2 0 0 2 2 2 2 PPIC-type PPIASE domain SurA_N PF09312.11 CDL01204.1 - 9.4e-17 61.2 6.8 2.6e-16 59.8 5.0 2.4 2 0 0 2 2 2 1 SurA N-terminal domain Rotamase_3 PF13616.6 CDL01204.1 - 1.6e-16 60.8 0.0 9.5e-16 58.4 0.0 2.1 2 1 0 2 2 2 1 PPIC-type PPIASE domain SurA_N_3 PF13624.6 CDL01204.1 - 2.3e-15 56.8 0.3 4.9e-15 55.7 0.3 1.5 1 0 0 1 1 1 1 SurA N-terminal domain SurA_N_2 PF13623.6 CDL01204.1 - 5e-10 39.4 0.1 1.2e-09 38.2 0.1 1.6 1 0 0 1 1 1 1 SurA N-terminal domain Rotamase_2 PF13145.6 CDL01204.1 - 6.6e-07 30.2 0.0 0.0013 19.6 0.0 2.6 2 1 0 2 2 2 2 PPIC-type PPIASE domain LptD PF04453.14 CDL01205.1 - 1.7e-42 146.0 2.4 2.5e-42 145.5 2.4 1.2 1 0 0 1 1 1 1 LPS transport system D OstA PF03968.14 CDL01205.1 - 0.004 17.3 0.1 0.028 14.6 0.1 2.5 3 0 0 3 3 3 1 OstA-like protein LEH PF07858.12 CDL01205.1 - 0.15 12.2 0.1 0.29 11.3 0.1 1.4 1 0 0 1 1 1 0 Limonene-1,2-epoxide hydrolase catalytic domain LptF_LptG PF03739.14 CDL01206.1 - 5.1e-61 206.5 7.4 5.7e-61 206.3 7.4 1.0 1 0 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG FtsX PF02687.21 CDL01206.1 - 0.27 11.7 0.1 0.27 11.7 0.1 3.8 3 1 0 3 3 3 0 FtsX-like permease family MCPsignal PF00015.21 CDL01207.1 - 1.3e-33 116.2 46.8 2.2e-33 115.5 24.3 3.2 1 1 2 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDL01207.1 - 1.3e-08 35.1 0.2 1.3e-08 35.1 0.2 3.9 4 0 0 4 4 4 1 HAMP domain 4HB_MCP_1 PF12729.7 CDL01207.1 - 9.9e-05 22.0 4.3 0.0008 19.0 0.0 3.7 2 1 0 3 3 3 1 Four helix bundle sensory module for signal transduction DUF948 PF06103.11 CDL01207.1 - 0.00026 21.2 28.1 0.0015 18.8 1.4 5.6 3 2 4 7 7 7 3 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 CDL01207.1 - 0.0037 17.3 14.5 0.051 13.6 3.2 4.1 3 2 2 5 5 5 2 Protein of unknown function (DUF1664) Laminin_I PF06008.14 CDL01207.1 - 0.0095 15.7 5.7 0.0095 15.7 5.7 3.2 2 1 0 3 3 3 2 Laminin Domain I PMC2NT PF08066.12 CDL01207.1 - 0.12 13.0 10.6 4.5 8.0 0.0 5.5 4 2 3 7 7 6 0 PMC2NT (NUC016) domain Renin_r PF07850.14 CDL01207.1 - 0.13 12.9 1.4 0.83 10.3 0.1 2.7 2 0 0 2 2 2 0 Renin receptor-like protein DUF2999 PF11212.8 CDL01207.1 - 0.14 12.5 1.9 16 5.8 0.0 3.2 4 0 0 4 4 3 0 Protein of unknown function (DUF2999) Lectin_N PF03954.14 CDL01207.1 - 0.33 10.7 5.5 4 7.2 0.0 3.8 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain Lipoprotein_7 PF01540.16 CDL01207.1 - 0.41 9.9 8.5 0.28 10.4 3.8 2.1 1 1 1 2 2 2 0 Adhesin lipoprotein K-cyclin_vir_C PF09080.10 CDL01207.1 - 2.5 8.6 10.3 3.2 8.2 1.1 4.1 3 1 1 4 4 4 0 K cyclin, C terminal CEP63 PF17045.5 CDL01207.1 - 3.5 7.5 10.8 5 7.0 6.9 2.8 2 1 0 2 2 2 0 Centrosomal protein of 63 kDa sCache_2 PF17200.4 CDL01208.1 - 3.1e-19 69.3 0.2 3.9e-19 69.0 0.2 1.1 1 0 0 1 1 1 1 Single Cache domain 2 dCache_2 PF08269.11 CDL01208.1 - 1.5e-17 63.7 0.1 1.9e-17 63.4 0.1 1.2 1 0 0 1 1 1 1 Cache domain Cache_3-Cache_2 PF17201.4 CDL01208.1 - 0.0052 16.1 0.0 0.0078 15.5 0.0 1.3 1 0 0 1 1 1 1 Cache 3/Cache 2 fusion domain Glyco_hydro_9 PF00759.19 CDL01208.1 - 0.18 11.2 3.4 0.24 10.8 3.4 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 FAD-oxidase_C PF02913.19 CDL01209.1 - 2.1e-56 191.3 0.1 3.5e-56 190.6 0.1 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CDL01209.1 - 1.6e-32 112.1 4.9 3.3e-32 111.1 4.9 1.5 1 0 0 1 1 1 1 FAD binding domain Herpes_capsid PF06112.11 CDL01209.1 - 0.19 11.8 0.0 0.35 10.9 0.0 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Sua5_yciO_yrdC PF01300.18 CDL01210.1 - 2.5e-55 186.7 0.0 3.3e-55 186.3 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 CDL01210.1 - 5.3e-23 82.1 1.2 2.2e-22 80.1 1.2 2.0 1 1 0 1 1 1 1 Putative GTP-binding controlling metal-binding Inositol_P PF00459.25 CDL01211.1 - 1.4e-48 165.7 0.0 1.8e-48 165.4 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Phage_holin_2_1 PF04971.12 CDL01214.1 - 0.95 9.5 4.5 0.2 11.7 0.5 1.9 2 0 0 2 2 2 0 Bacteriophage P21 holin S Memo PF01875.17 CDL01215.1 - 1.6e-50 171.8 0.0 2.1e-50 171.4 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein AMMECR1 PF01871.17 CDL01215.1 - 1.9e-45 154.5 0.0 2.6e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 AMMECR1 Radical_SAM PF04055.21 CDL01216.1 - 7.8e-14 52.4 0.1 1.6e-13 51.4 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CDL01216.1 - 0.019 15.2 0.0 0.037 14.3 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain zf-ribbon_3 PF13248.6 CDL01216.1 - 0.048 13.1 0.1 0.048 13.1 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 CDL01216.1 - 0.15 11.6 0.1 0.15 11.6 0.1 2.7 3 0 0 3 3 3 0 TFIIB zinc-binding DZR PF12773.7 CDL01216.1 - 0.28 11.3 0.2 0.28 11.3 0.2 3.2 3 1 0 3 3 3 0 Double zinc ribbon zf-RRN7 PF11781.8 CDL01216.1 - 6.3 6.6 11.3 0.52 10.0 0.2 3.7 4 0 0 4 4 4 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 LPG_synthase_TM PF03706.13 CDL01217.1 - 2.9e-44 151.8 46.5 3.5e-44 151.5 46.5 1.0 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region Peptidase_M17 PF00883.21 CDL01218.1 - 1.1e-124 415.8 2.4 1.4e-124 415.4 2.4 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CDL01218.1 - 5.1e-25 87.8 1.8 1.2e-24 86.5 1.8 1.7 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain Peptidase_M17 PF00883.21 CDL01219.1 - 2.9e-107 358.5 0.1 3.8e-107 358.2 0.1 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain DNA_pol3_chi PF04364.13 CDL01220.1 - 5.7e-37 126.9 0.0 6.5e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 DNA polymerase III chi subunit, HolC NAD_binding_1 PF00175.21 CDL01220.1 - 0.062 13.9 0.1 0.39 11.4 0.1 2.0 1 1 1 2 2 2 0 Oxidoreductase NAD-binding domain DUF4136 PF13590.6 CDL01221.1 - 1.4e-06 28.9 0.0 1.7e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4136) MarR PF01047.22 CDL01222.1 - 2.5e-13 49.7 0.1 3.4e-13 49.3 0.1 1.2 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 CDL01222.1 - 1.7e-12 47.0 0.5 2.7e-12 46.4 0.5 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 CDL01222.1 - 3.5e-08 33.8 0.2 5.7e-08 33.1 0.2 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain GntR PF00392.21 CDL01222.1 - 0.0003 20.4 0.0 0.00069 19.2 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family TrmB PF01978.19 CDL01222.1 - 0.00076 19.3 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 CDL01222.1 - 0.001 18.6 0.1 0.002 17.6 0.1 1.6 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 CDL01222.1 - 0.0011 18.8 0.1 0.0035 17.3 0.0 1.8 2 0 0 2 2 2 1 HTH domain HTH_5 PF01022.20 CDL01222.1 - 0.0045 16.8 0.0 0.0071 16.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family TBPIP PF07106.13 CDL01222.1 - 0.0056 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain DUF4423 PF14394.6 CDL01222.1 - 0.007 16.1 0.0 0.0079 15.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) Fe_dep_repress PF01325.19 CDL01222.1 - 0.0079 16.4 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_Crp_2 PF13545.6 CDL01222.1 - 0.012 15.5 0.1 0.02 14.9 0.1 1.4 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_IclR PF09339.10 CDL01222.1 - 0.05 13.4 0.2 0.083 12.7 0.2 1.5 1 1 0 1 1 1 0 IclR helix-turn-helix domain Dimerisation2 PF16864.5 CDL01222.1 - 0.058 13.4 0.0 0.081 12.9 0.0 1.3 1 0 0 1 1 1 0 Dimerisation domain DUF4194 PF13835.6 CDL01222.1 - 0.06 13.1 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4194) Peptidase_M17 PF00883.21 CDL01223.1 - 3.7e-105 351.7 0.1 4.4e-105 351.4 0.1 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CDL01223.1 - 0.017 14.9 0.6 0.77 9.6 0.0 3.2 2 1 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain GST_N_3 PF13417.6 CDL01224.1 - 5.2e-15 55.6 0.0 9.2e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDL01224.1 - 2.4e-12 47.0 0.1 3.8e-12 46.3 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDL01224.1 - 6.6e-12 45.6 0.0 1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CDL01224.1 - 1.6e-05 24.9 0.1 2.7e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CDL01224.1 - 0.00075 20.2 0.0 0.0012 19.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_4 PF14834.6 CDL01224.1 - 0.002 18.5 0.1 0.0033 17.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF4728 PF15860.5 CDL01224.1 - 0.065 13.9 0.0 0.099 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4728) Tom37 PF10568.9 CDL01224.1 - 0.18 12.1 0.0 0.26 11.6 0.0 1.3 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein CBS PF00571.28 CDL01225.1 - 1.1e-24 86.6 1.8 3.4e-13 49.8 0.6 2.1 2 0 0 2 2 2 2 CBS domain YhfC PF10086.9 CDL01226.1 - 1.4 8.3 4.7 0.27 10.6 0.7 1.6 1 1 1 2 2 2 0 YhfC intramembrane metalloprotease Methyltr_RsmB-F PF01189.17 CDL01227.1 - 9.6e-50 169.0 0.0 1.4e-49 168.5 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 CDL01227.1 - 1.1e-10 41.5 0.0 1.7e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL01227.1 - 8.5e-09 36.0 0.3 2.4e-06 28.1 0.2 3.3 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDL01227.1 - 4.2e-07 29.5 0.0 2.9e-05 23.5 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 CDL01227.1 - 3.5e-05 23.7 0.0 6.7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 CDL01227.1 - 4.6e-05 24.4 0.2 0.00019 22.4 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL01227.1 - 5.6e-05 23.7 0.3 0.0012 19.5 0.1 2.9 2 1 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.19 CDL01227.1 - 7.7e-05 22.9 0.0 0.00012 22.3 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmF_N PF17125.5 CDL01227.1 - 0.0013 19.1 0.0 0.0029 18.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF MTS PF05175.14 CDL01227.1 - 0.0024 17.4 0.1 0.013 15.1 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 CDL01227.1 - 0.0095 16.7 0.0 0.62 10.8 0.0 3.1 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_3 PF01596.17 CDL01227.1 - 0.069 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase GCD14 PF08704.10 CDL01227.1 - 0.091 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_4 PF02390.17 CDL01227.1 - 0.093 12.2 0.0 0.4 10.1 0.0 2.0 1 1 0 1 1 1 0 Putative methyltransferase PrmA PF06325.13 CDL01227.1 - 0.17 11.2 0.0 0.4 10.0 0.1 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) UPF0728 PF15092.6 CDL01228.1 - 0.01 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0728 IMPDH PF00478.25 CDL01229.1 - 4.9e-157 522.3 10.2 6.1e-157 522.0 10.2 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 CDL01229.1 - 1.1e-19 70.6 1.4 7.2e-12 45.6 0.1 2.7 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 CDL01229.1 - 7.9e-12 45.2 10.0 2.7e-08 33.6 5.4 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 CDL01229.1 - 2.5e-06 26.8 13.5 3.4e-06 26.3 12.0 2.0 2 1 0 2 2 2 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 CDL01229.1 - 2.7e-06 26.8 7.6 4.6e-06 26.0 7.6 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 CDL01229.1 - 7.8e-05 22.2 5.8 0.04 13.4 0.3 2.9 1 1 1 3 3 3 2 Histidine biosynthesis protein PcrB PF01884.17 CDL01229.1 - 0.00049 19.6 4.7 0.071 12.6 0.7 2.5 2 0 0 2 2 2 2 PcrB family NanE PF04131.14 CDL01229.1 - 0.00074 18.8 5.4 0.0049 16.1 5.4 2.6 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase B12-binding PF02310.19 CDL01229.1 - 0.013 15.6 4.3 0.013 15.5 0.6 2.3 2 0 0 2 2 2 0 B12 binding domain IGPS PF00218.21 CDL01229.1 - 0.023 13.9 1.7 2.2 7.4 0.0 2.9 3 0 0 3 3 3 0 Indole-3-glycerol phosphate synthase TMP-TENI PF02581.17 CDL01229.1 - 0.028 13.7 6.5 0.023 14.0 3.7 2.2 2 1 1 3 3 3 0 Thiamine monophosphate synthase G3P_antiterm PF04309.12 CDL01229.1 - 0.047 13.1 3.7 2.7 7.4 0.2 2.6 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator GP70 PF17429.2 CDL01229.1 - 0.052 13.4 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Gene product 70 Ribul_P_3_epim PF00834.19 CDL01229.1 - 0.092 12.1 3.7 0.49 9.8 3.7 2.3 1 1 0 1 1 1 0 Ribulose-phosphate 3 epimerase family DHO_dh PF01180.21 CDL01229.1 - 0.69 9.1 8.4 0.43 9.8 2.5 2.2 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase DeoC PF01791.9 CDL01229.1 - 1.1 8.8 8.8 1.5 8.4 5.2 2.2 1 1 1 2 2 2 0 DeoC/LacD family aldolase Host_attach PF10116.9 CDL01230.1 - 6e-18 65.8 0.0 5.7e-12 46.4 0.1 2.0 2 0 0 2 2 2 2 Protein required for attachment to host cells baeRF_family12 PF18856.1 CDL01230.1 - 2.6e-15 57.2 0.0 1.2e-10 42.1 0.0 2.0 2 0 0 2 2 2 2 Bacterial archaeo-eukaryotic release factor family 12 baeRF_family10 PF18854.1 CDL01230.1 - 2e-08 34.6 0.8 3.6e-08 33.8 0.5 1.5 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 baeRF_family5 PF18846.1 CDL01230.1 - 0.0067 16.6 0.0 0.0084 16.3 0.0 1.1 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 5 acVLRF1 PF18859.1 CDL01230.1 - 0.0075 16.6 0.3 0.01 16.1 0.3 1.2 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family2 PF18844.1 CDL01230.1 - 0.031 14.3 0.8 0.041 13.9 0.8 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 2 FtsJ PF01728.19 CDL01231.1 - 3.4e-56 190.1 0.0 4.5e-56 189.7 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 CDL01231.1 - 0.00051 19.9 0.0 0.023 14.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL01231.1 - 0.017 14.9 0.0 0.029 14.2 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CDL01231.1 - 0.038 13.8 0.0 0.089 12.5 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 CDL01231.1 - 0.094 13.4 0.4 0.33 11.7 0.1 2.0 2 1 0 2 2 2 0 Methyltransferase domain NSP16 PF06460.12 CDL01231.1 - 0.26 10.4 0.0 0.28 10.2 0.0 1.1 1 0 0 1 1 1 0 Coronavirus NSP16 Ppx-GppA PF02541.16 CDL01232.1 - 1.4e-50 172.4 0.1 1.6e-50 172.2 0.1 1.0 1 0 0 1 1 1 1 Ppx/GppA phosphatase family Peptidase_M50 PF02163.22 CDL01234.1 - 7e-05 22.2 2.1 0.00077 18.8 2.1 2.1 1 1 0 1 1 1 1 Peptidase family M50 OEP PF02321.18 CDL01235.1 - 1.1e-24 87.4 28.7 4e-16 59.4 11.4 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein HAUS2 PF15003.6 CDL01235.1 - 0.033 13.9 2.1 0.038 13.7 0.6 1.8 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 DUF4347 PF14252.6 CDL01236.1 - 1.1e-49 168.4 3.8 1.1e-49 168.4 3.8 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4347) eRF1_1 PF03463.15 CDL01236.1 - 0.0025 17.8 0.9 2.9 7.9 0.0 6.1 7 0 0 7 7 7 1 eRF1 domain 1 Multi_Drug_Res PF00893.19 CDL01236.1 - 0.52 11.0 7.4 13 6.5 0.1 4.3 4 0 0 4 4 4 0 Small Multidrug Resistance protein DUF4479 PF14794.6 CDL01236.1 - 3.3 7.6 20.4 22 5.0 0.0 9.4 10 0 0 10 10 10 0 Domain of unknown function (DUF4479) Autoind_bind PF03472.15 CDL01237.1 - 4.1e-28 97.7 0.2 6e-28 97.2 0.2 1.3 1 0 0 1 1 1 1 Autoinducer binding domain GerE PF00196.19 CDL01237.1 - 1.6e-18 66.0 0.1 2.5e-18 65.4 0.1 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4 PF04545.16 CDL01237.1 - 2.7e-05 23.6 0.0 5.6e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4_2 PF08281.12 CDL01237.1 - 0.00083 19.0 0.0 0.0063 16.2 0.0 2.3 3 0 0 3 3 3 1 Sigma-70, region 4 HTH_23 PF13384.6 CDL01237.1 - 0.0024 17.6 0.5 0.022 14.5 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_10 PF04967.12 CDL01237.1 - 0.0035 17.1 0.1 0.01 15.6 0.0 1.8 2 0 0 2 2 2 1 HTH DNA binding domain HTH_38 PF13936.6 CDL01237.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_28 PF13518.6 CDL01237.1 - 0.077 13.1 0.1 22 5.3 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain GerE PF00196.19 CDL01238.1 - 9.6e-15 53.9 0.0 1.5e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDL01238.1 - 0.00018 21.1 0.0 0.0039 16.8 0.0 2.4 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_7 PF02796.15 CDL01238.1 - 0.015 15.3 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 CDL01238.1 - 0.058 13.2 0.0 0.29 11.0 0.0 2.1 1 1 1 2 2 2 0 Homeodomain-like domain Response_reg PF00072.24 CDL01239.1 - 1.1e-19 70.6 0.0 1.3e-19 70.4 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Response_reg PF00072.24 CDL01240.1 - 0.00097 19.3 0.0 0.0013 18.9 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain GGDEF_2 PF17853.1 CDL01240.1 - 0.0041 17.4 0.1 0.0053 17.0 0.1 1.2 1 0 0 1 1 1 1 GGDEF-like domain NTP_transf_5 PF14907.6 CDL01241.1 - 0.18 11.4 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase Recombinase PF07508.13 CDL01242.1 - 2.3e-13 50.4 0.0 5.4e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 Recombinase Zn_ribbon_recom PF13408.6 CDL01242.1 - 7.4e-06 26.4 0.0 1.6e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain DNA_methylase PF00145.17 CDL01244.1 - 4.4e-14 52.6 0.0 5.7e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase HATPase_c_3 PF13589.6 CDL01244.1 - 6.2e-13 48.8 0.0 1.2e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HTH_31 PF13560.6 CDL01245.1 - 1.2e-08 35.2 0.2 1.6e-08 34.8 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 CDL01245.1 - 0.00044 20.0 0.0 0.0012 18.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 CDL01245.1 - 0.0035 17.4 0.0 0.0054 16.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_26 PF13443.6 CDL01245.1 - 0.14 12.6 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain HipA_C PF07804.12 CDL01246.1 - 1.2e-46 159.1 0.0 1.7e-46 158.6 0.0 1.2 1 0 0 1 1 1 1 HipA-like C-terminal domain Couple_hipA PF13657.6 CDL01246.1 - 0.00012 22.7 0.0 0.00034 21.2 0.0 1.7 1 0 0 1 1 1 1 HipA N-terminal domain CotH PF08757.11 CDL01246.1 - 0.031 13.8 0.0 0.047 13.2 0.0 1.3 1 0 0 1 1 1 0 CotH kinase protein Death PF00531.22 CDL01246.1 - 0.054 13.7 0.0 1 9.6 0.0 2.5 2 0 0 2 2 2 0 Death domain AAA_15 PF13175.6 CDL01248.1 - 2.4e-08 34.1 0.0 2.5e-08 34.1 0.0 1.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CDL01248.1 - 2.7e-08 34.6 0.0 3.4e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDL01248.1 - 1.8e-07 30.8 0.0 2.9e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CDL01248.1 - 4.7e-05 23.3 0.0 8.2e-05 22.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDL01248.1 - 0.00018 21.0 0.0 0.00023 20.7 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF2813 PF11398.8 CDL01248.1 - 0.0011 18.3 0.0 0.0013 18.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2813) AAA_25 PF13481.6 CDL01248.1 - 0.051 13.2 0.0 0.14 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 CDL01248.1 - 0.2 11.2 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 CDL01248.1 - 0.24 10.5 0.0 0.31 10.2 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit RecJ_OB PF17768.1 CDL01249.1 - 4e-23 81.7 0.0 6.2e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 RecJ OB domain DHHA1 PF02272.19 CDL01249.1 - 5e-19 69.1 0.4 5e-19 69.1 0.4 1.7 2 0 0 2 2 2 1 DHHA1 domain DHH PF01368.20 CDL01249.1 - 4e-08 33.4 0.0 7.6e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 DHH family FBPase_glpX PF03320.13 CDL01250.1 - 9.1e-121 402.4 7.6 1e-120 402.3 7.6 1.0 1 0 0 1 1 1 1 Bacterial fructose-1,6-bisphosphatase, glpX-encoded Homoserine_dh PF00742.19 CDL01251.1 - 2e-63 213.4 0.1 3e-63 212.9 0.1 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 CDL01251.1 - 3.4e-14 53.5 3.3 7.2e-14 52.4 3.3 1.6 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ACT PF01842.25 CDL01251.1 - 8.1e-07 28.7 0.0 3.2e-06 26.8 0.0 2.2 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 CDL01251.1 - 0.0029 18.1 0.0 0.0074 16.9 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT_7 PF13840.6 CDL01251.1 - 0.01 15.6 0.1 0.041 13.7 0.0 2.1 2 0 0 2 2 2 0 ACT domain Sacchrp_dh_NADP PF03435.18 CDL01251.1 - 0.024 14.9 2.9 0.063 13.5 2.9 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_Gly3P_dh_N PF01210.23 CDL01251.1 - 0.029 14.4 1.0 0.058 13.4 1.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF1611_N PF17396.2 CDL01251.1 - 0.064 13.5 1.1 0.24 11.7 1.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_N) Rossmann-like domain DUF2478 PF10649.9 CDL01251.1 - 0.086 12.4 1.9 3.3 7.3 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2478) adh_short PF00106.25 CDL01251.1 - 2 7.9 7.2 0.35 10.3 1.4 2.5 2 1 1 3 3 3 0 short chain dehydrogenase Aminotran_1_2 PF00155.21 CDL01252.1 - 1e-56 192.7 0.0 1.2e-56 192.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II 4HB_MCP_1 PF12729.7 CDL01253.1 - 1.4e-33 116.0 0.5 1.4e-33 116.0 0.5 3.9 4 1 0 4 4 4 1 Four helix bundle sensory module for signal transduction MCPsignal PF00015.21 CDL01253.1 - 1.6e-32 112.7 56.8 5.2e-32 111.0 31.0 3.4 2 2 2 4 4 4 2 Methyl-accepting chemotaxis protein (MCP) signalling domain TarH PF02203.15 CDL01253.1 - 4.3e-12 46.3 0.4 4.3e-12 46.3 0.4 4.9 4 2 0 4 4 4 1 Tar ligand binding domain homologue HAMP PF00672.25 CDL01253.1 - 2e-06 28.1 0.1 2e-06 28.1 0.1 3.5 3 1 0 3 3 3 1 HAMP domain DUF1664 PF07889.12 CDL01253.1 - 0.036 14.1 18.4 0.2 11.7 2.4 4.0 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 CDL01253.1 - 0.091 10.7 11.4 4 5.2 9.9 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Tup_N PF08581.10 CDL01253.1 - 0.41 11.0 2.9 1.8 8.9 0.1 3.1 3 0 0 3 3 3 0 Tup N-terminal Syntaxin-6_N PF09177.11 CDL01253.1 - 0.44 11.1 16.8 0.087 13.4 2.0 3.5 3 2 0 3 3 3 0 Syntaxin 6, N-terminal DUF2293 PF10056.9 CDL01254.1 - 1.2e-17 63.9 0.0 1.5e-17 63.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) OmpA PF00691.20 CDL01255.1 - 8.7e-07 29.2 0.0 2e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 OmpA family DUF5539 PF17693.1 CDL01255.1 - 0.66 9.6 16.6 0.51 9.9 14.6 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5539) PhaC_N PF07167.13 CDL01256.1 - 9.2e-81 269.6 0.0 1.6e-80 268.8 0.0 1.4 1 0 0 1 1 1 1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus Abhydrolase_1 PF00561.20 CDL01256.1 - 5.5e-10 39.3 0.0 2.8e-09 37.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 CDL01256.1 - 8.7e-05 22.2 0.1 0.017 14.7 0.1 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family DUF3141 PF11339.8 CDL01256.1 - 0.037 12.5 0.1 0.082 11.3 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3141) ABC_tran PF00005.27 CDL01257.1 - 8.8e-53 178.5 0.1 7.7e-25 88.0 0.0 2.9 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 CDL01257.1 - 1.3e-16 61.4 4.5 7.7e-05 22.6 0.0 4.3 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 CDL01257.1 - 5.1e-15 55.3 8.1 1.2e-13 50.9 2.1 2.8 3 0 0 3 3 3 1 ABC transporter SMC_N PF02463.19 CDL01257.1 - 5.9e-10 39.0 1.3 0.2 11.1 0.0 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDL01257.1 - 1.4e-05 25.4 0.6 0.026 14.8 0.0 3.5 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CDL01257.1 - 1.8e-05 24.4 1.0 0.049 13.4 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CDL01257.1 - 2.2e-05 24.5 0.3 0.043 13.9 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase NB-ARC PF00931.22 CDL01257.1 - 2.8e-05 23.4 0.0 0.0078 15.4 0.0 2.6 2 1 0 2 2 2 1 NB-ARC domain AAA_23 PF13476.6 CDL01257.1 - 0.0001 22.9 0.6 0.0001 22.9 0.6 3.6 4 0 0 4 4 4 1 AAA domain AAA_18 PF13238.6 CDL01257.1 - 0.00019 22.0 0.8 0.59 10.7 0.2 3.4 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDL01257.1 - 0.0003 21.2 6.3 0.095 13.1 0.0 3.8 2 1 1 3 3 3 1 AAA ATPase domain Dynamin_N PF00350.23 CDL01257.1 - 0.00057 20.0 0.0 0.61 10.1 0.0 2.7 3 0 0 3 3 2 1 Dynamin family RsgA_GTPase PF03193.16 CDL01257.1 - 0.0007 19.5 0.3 0.33 10.9 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 CDL01257.1 - 0.0018 18.0 1.8 1.2 8.8 0.0 2.8 3 0 0 3 3 2 2 AAA domain DLIC PF05783.11 CDL01257.1 - 0.0019 17.1 0.2 0.29 9.9 0.0 2.3 2 0 0 2 2 2 1 Dynein light intermediate chain (DLIC) AAA_28 PF13521.6 CDL01257.1 - 0.002 18.4 2.1 0.35 11.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain SbcCD_C PF13558.6 CDL01257.1 - 0.0028 17.8 1.2 6.8 7.0 0.0 4.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Roc PF08477.13 CDL01257.1 - 0.014 15.6 2.4 1.1 9.5 0.0 3.4 4 0 0 4 4 3 0 Ras of Complex, Roc, domain of DAPkinase Seryl_tRNA_N PF02403.22 CDL01257.1 - 0.015 15.5 0.2 0.015 15.5 0.2 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain AAA_13 PF13166.6 CDL01257.1 - 0.02 13.6 8.4 0.18 10.4 0.0 3.7 2 1 1 3 3 3 0 AAA domain AAA_14 PF13173.6 CDL01257.1 - 0.025 14.6 0.0 4.7 7.3 0.0 3.2 4 0 0 4 4 3 0 AAA domain NACHT PF05729.12 CDL01257.1 - 0.025 14.5 1.8 2.5 8.0 0.0 2.7 3 0 0 3 3 2 0 NACHT domain MeaB PF03308.16 CDL01257.1 - 0.027 13.5 0.7 0.29 10.1 0.1 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 CDL01257.1 - 0.035 13.8 3.3 4.9 6.8 0.2 2.7 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CDL01257.1 - 0.047 13.3 3.3 1.1 8.8 0.6 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 CDL01257.1 - 0.049 14.0 1.2 1.1 9.6 0.1 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CDL01257.1 - 0.059 13.5 5.8 0.62 10.2 0.1 3.2 3 1 0 3 3 3 0 AAA domain AAA_27 PF13514.6 CDL01257.1 - 0.11 12.0 4.1 1.2 8.7 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_15 PF13175.6 CDL01257.1 - 0.12 12.1 0.0 6.1 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain Arf PF00025.21 CDL01257.1 - 0.14 11.6 2.3 7.5 6.0 0.2 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family RecA PF00154.21 CDL01257.1 - 0.17 11.4 0.2 0.97 8.8 0.0 2.0 2 0 0 2 2 2 0 recA bacterial DNA recombination protein FeoB_N PF02421.18 CDL01257.1 - 0.33 10.5 3.0 1.4 8.4 0.1 2.6 3 0 0 3 3 2 0 Ferrous iron transport protein B AAA_25 PF13481.6 CDL01257.1 - 0.37 10.4 5.7 14 5.2 0.0 3.9 4 1 0 4 4 3 0 AAA domain AAA_17 PF13207.6 CDL01257.1 - 0.51 10.7 2.7 20 5.6 0.9 3.1 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CDL01257.1 - 0.52 10.0 1.8 3.1 7.5 0.1 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 CDL01257.1 - 0.57 10.2 2.8 2.2 8.3 0.0 2.7 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF3584 PF12128.8 CDL01257.1 - 0.72 7.3 8.7 0.37 8.3 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) EFG_IV PF03764.18 CDL01258.1 - 2.1e-42 143.7 0.0 3.5e-42 143.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU PF00009.27 CDL01258.1 - 2.6e-24 85.9 0.0 1.7e-23 83.2 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CDL01258.1 - 3.4e-19 68.7 0.0 7e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CDL01258.1 - 9.2e-18 64.1 0.0 1.8e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 CDL01258.1 - 0.0012 18.9 0.0 0.0029 17.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CDL01258.1 - 0.0025 17.9 0.0 0.0097 16.0 0.0 1.9 2 0 0 2 2 2 1 Dynamin family SRPRB PF09439.10 CDL01258.1 - 0.009 15.5 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_21 PF13304.6 CDL01258.1 - 0.04 13.7 0.0 0.09 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP_bind_1 PF03029.17 CDL01258.1 - 0.2 11.4 0.0 30 4.3 0.0 3.1 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein DUF853 PF05872.12 CDL01261.1 - 3.3e-220 731.9 0.0 3.9e-220 731.7 0.0 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) DUF87 PF01935.17 CDL01261.1 - 4.4e-09 36.8 0.0 6.5e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 CDL01261.1 - 3.1e-06 26.7 0.4 9e-05 21.9 0.1 2.7 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_10 PF12846.7 CDL01261.1 - 0.00013 21.0 0.0 0.17 10.8 0.0 2.1 2 0 0 2 2 2 2 AAA-like domain AAA_22 PF13401.6 CDL01261.1 - 0.0005 20.3 0.1 0.079 13.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.9 CDL01261.1 - 0.001 18.0 0.0 0.0043 16.0 0.0 1.8 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.6 CDL01261.1 - 0.0015 18.3 0.7 0.015 15.0 0.4 2.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CDL01261.1 - 0.0039 17.6 0.0 2 8.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 CDL01261.1 - 0.0043 17.1 0.0 0.25 11.3 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_16 PF13191.6 CDL01261.1 - 0.036 14.4 1.7 1.2 9.5 0.1 2.8 2 1 0 2 2 2 0 AAA ATPase domain DUF2075 PF09848.9 CDL01261.1 - 0.04 13.1 0.3 2.6 7.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 CDL01261.1 - 0.049 13.2 0.1 0.2 11.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain Zot PF05707.12 CDL01261.1 - 0.13 11.8 0.0 0.3 10.7 0.0 1.5 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) T2SSE PF00437.20 CDL01261.1 - 0.17 10.9 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Peptidase_C1 PF00112.23 CDL01262.1 - 2.3e-19 70.3 0.5 3.6e-19 69.7 0.5 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C39_2 PF13529.6 CDL01262.1 - 6.7e-05 23.5 0.0 0.00029 21.4 0.0 1.9 2 0 0 2 2 2 1 Peptidase_C39 like family HHH_5 PF14520.6 CDL01263.1 - 0.012 16.2 0.4 0.033 14.8 0.2 1.7 1 1 1 2 2 2 0 Helix-hairpin-helix domain HD PF01966.22 CDL01264.1 - 1.3e-26 93.2 4.9 1.5e-20 73.7 0.8 2.5 2 0 0 2 2 2 2 HD domain HD_5 PF13487.6 CDL01264.1 - 1.7e-13 50.6 0.2 6.8e-12 45.5 0.0 2.6 3 0 0 3 3 3 1 HD domain HDOD PF08668.12 CDL01264.1 - 4.7e-06 26.2 0.0 0.018 14.5 0.0 2.5 2 0 0 2 2 2 2 HDOD domain HD_6 PF18019.1 CDL01264.1 - 0.42 10.7 10.4 1.7 8.7 1.3 2.7 2 1 0 2 2 2 0 HD domain HATPase_c PF02518.26 CDL01265.1 - 2e-17 63.7 0.0 3.5e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 CDL01265.1 - 5.2e-13 49.4 0.0 8.5e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Cache domain HisKA PF00512.25 CDL01265.1 - 3.1e-11 43.2 1.4 6.5e-11 42.1 0.2 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain RskA PF10099.9 CDL01265.1 - 0.85 9.9 16.0 0.44 10.8 0.2 3.1 2 2 1 3 3 3 0 Anti-sigma-K factor rskA ABC_tran PF00005.27 CDL01266.1 - 8.5e-45 152.6 0.0 3.9e-23 82.5 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CDL01266.1 - 4.4e-24 84.3 3.7 1.1e-22 79.9 0.2 2.5 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CDL01266.1 - 3.7e-16 59.8 6.6 9.8e-06 25.6 0.0 4.2 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_CTD PF16326.5 CDL01266.1 - 1.3e-12 47.7 5.2 1.7e-11 44.2 1.6 2.7 2 0 0 2 2 2 1 ABC transporter C-terminal domain SMC_N PF02463.19 CDL01266.1 - 1.1e-09 38.0 0.3 0.0026 17.2 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDL01266.1 - 2e-07 30.6 0.1 0.021 14.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CDL01266.1 - 2.5e-06 27.6 0.1 0.0062 16.6 0.0 2.8 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 CDL01266.1 - 3.7e-05 24.3 0.1 0.0082 16.7 0.0 3.1 3 1 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 CDL01266.1 - 5.8e-05 23.0 0.6 0.22 11.4 0.0 2.7 3 0 0 3 3 2 2 RsgA GTPase AAA_16 PF13191.6 CDL01266.1 - 0.0023 18.3 2.8 1.9 8.8 0.0 3.1 2 1 0 2 2 2 2 AAA ATPase domain SbcCD_C PF13558.6 CDL01266.1 - 0.0053 17.0 0.1 0.6 10.4 0.1 3.4 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 CDL01266.1 - 0.0058 16.4 3.3 0.4 10.4 0.2 3.3 2 2 0 2 2 2 1 AAA domain AAA_15 PF13175.6 CDL01266.1 - 0.011 15.5 0.2 6 6.5 0.0 3.2 3 0 0 3 3 3 0 AAA ATPase domain DUF87 PF01935.17 CDL01266.1 - 0.014 15.5 5.9 1.9 8.5 0.1 3.3 4 0 0 4 4 4 0 Helicase HerA, central domain AAA_13 PF13166.6 CDL01266.1 - 0.016 13.9 4.2 2.3 6.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain MeaB PF03308.16 CDL01266.1 - 0.018 14.1 0.8 0.36 9.8 0.1 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 CDL01266.1 - 0.019 14.6 1.5 1.4 8.4 0.2 3.6 3 1 0 3 3 3 0 AAA domain NB-ARC PF00931.22 CDL01266.1 - 0.032 13.4 0.3 1.6 7.9 0.1 2.4 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 CDL01266.1 - 0.04 14.3 0.1 7.1 7.1 0.0 2.6 2 0 0 2 2 2 0 RNA helicase DUF815 PF05673.13 CDL01266.1 - 0.047 12.8 0.4 1.6 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NACHT PF05729.12 CDL01266.1 - 0.056 13.4 0.1 12 5.8 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 CDL01266.1 - 0.058 13.6 2.5 17 5.5 0.1 3.6 2 2 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDL01266.1 - 0.058 13.6 1.9 0.95 9.7 0.0 3.5 3 1 0 4 4 4 0 AAA domain AAA_23 PF13476.6 CDL01266.1 - 0.091 13.3 10.6 0.29 11.6 0.0 3.6 4 0 0 4 4 3 0 AAA domain AAA_24 PF13479.6 CDL01266.1 - 0.18 11.5 0.1 20 4.9 0.1 2.5 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CDL01266.1 - 0.24 11.1 1.6 8.6 6.1 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation PspA_IM30 PF04012.12 CDL01266.1 - 7.1 6.1 16.1 3 7.4 2.2 3.2 2 1 1 3 3 3 0 PspA/IM30 family NDK PF00334.19 CDL01267.1 - 1.4e-54 183.8 0.1 1.6e-54 183.6 0.1 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase HTH_3 PF01381.22 CDL01269.1 - 1.8e-12 47.1 0.2 4.6e-12 45.8 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 CDL01269.1 - 1.7e-08 34.7 0.3 1.7e-08 34.7 0.3 2.7 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_19 PF12844.7 CDL01269.1 - 8.6e-08 32.1 0.0 1.7e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 CDL01269.1 - 0.0077 16.7 0.0 0.013 15.9 0.0 1.4 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain Pou PF00157.17 CDL01269.1 - 0.066 13.2 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Pou domain - N-terminal to homeobox domain Cation_efflux PF01545.21 CDL01270.1 - 1e-34 120.0 17.7 1.2e-34 119.8 17.7 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CDL01270.1 - 3.2e-24 84.8 0.2 4.8e-24 84.3 0.2 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Putative_PNPOx PF01243.20 CDL01271.1 - 2e-24 85.6 0.0 3e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 CDL01271.1 - 2.1e-15 56.5 4.2 4.2e-15 55.5 4.2 1.5 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxase_2 PF12766.7 CDL01271.1 - 7e-07 29.8 0.0 1e-06 29.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 CDL01271.1 - 0.0061 16.2 0.0 0.0089 15.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like 17kDa_Anti_2 PF16998.5 CDL01272.1 - 6e-11 42.3 0.8 7.8e-11 41.9 0.8 1.1 1 0 0 1 1 1 1 17 kDa outer membrane surface antigen Rick_17kDa_Anti PF05433.15 CDL01272.1 - 2.4e-07 30.5 18.4 4.3e-07 29.7 18.4 1.4 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 CDL01272.1 - 3.9e-06 26.7 9.5 8e-06 25.8 9.5 1.5 1 0 0 1 1 1 1 Glycine zipper Gly-zipper_YMGG PF13441.6 CDL01272.1 - 0.0013 18.4 17.9 0.0039 16.9 17.9 1.8 1 1 1 2 2 2 2 YMGG-like Gly-zipper DUF456 PF04306.13 CDL01272.1 - 0.0043 17.3 3.9 0.0055 17.0 3.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF456) TraT PF05818.12 CDL01272.1 - 0.014 15.1 2.5 0.016 14.9 2.5 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Bacteriocin_IIc PF10439.9 CDL01272.1 - 0.017 15.2 14.2 0.029 14.5 14.2 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide DUF5061 PF16587.5 CDL01272.1 - 0.043 13.9 2.3 0.28 11.3 0.2 2.2 1 1 1 2 2 2 0 17 kDa common-antigen outer membrane protein LPAM_1 PF08139.12 CDL01272.1 - 0.091 13.3 0.6 0.2 12.2 0.6 1.6 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Gly-zipper_OmpA PF13436.6 CDL01272.1 - 2.1 8.2 16.4 19 5.2 16.4 2.2 1 1 0 1 1 1 0 Glycine-zipper domain DnaJ_C PF01556.18 CDL01273.1 - 1.2e-27 96.8 0.0 1.7e-27 96.3 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDL01273.1 - 3.5e-26 91.1 0.9 6.4e-26 90.3 0.9 1.5 1 0 0 1 1 1 1 DnaJ domain GATase_3 PF07685.14 CDL01274.1 - 1.5e-32 112.8 0.0 2.3e-32 112.2 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AAA_26 PF13500.6 CDL01274.1 - 2.3e-18 66.8 0.1 3.2e-12 46.7 0.0 2.3 1 1 1 2 2 2 2 AAA domain CbiA PF01656.23 CDL01274.1 - 3.6e-16 59.4 0.0 6.9e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 CDL01274.1 - 0.0081 16.1 0.0 0.068 13.1 0.0 2.4 2 1 1 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B SNO PF01174.19 CDL01274.1 - 0.016 15.0 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 SNO glutamine amidotransferase family Glycos_trans_3N PF02885.17 CDL01275.1 - 7e-12 45.0 4.6 2.2e-11 43.4 0.0 2.6 2 1 0 2 2 2 1 Glycosyl transferase family, helical bundle domain Glycos_transf_3 PF00591.21 CDL01275.1 - 5.5e-09 36.0 0.4 1.4e-08 34.6 0.4 1.7 1 1 0 1 1 1 1 Glycosyl transferase family, a/b domain Radical_SAM PF04055.21 CDL01276.1 - 3.2e-15 56.9 0.0 4.4e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily DUF4917 PF16263.5 CDL01276.1 - 0.06 12.7 0.0 0.082 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4917) DUF1848 PF08902.11 CDL01276.1 - 0.41 10.3 1.3 0.62 9.7 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) ABC_trans_aux PF03886.13 CDL01277.1 - 0.0055 16.3 0.3 0.0081 15.7 0.3 1.2 1 0 0 1 1 1 1 ABC-type transport auxiliary lipoprotein component DUF179 PF02622.15 CDL01278.1 - 7.4e-48 162.5 0.0 8.4e-48 162.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 FAD_binding_6 PF00970.24 CDL01278.1 - 0.035 14.5 0.0 0.053 13.9 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain DsbC PF11412.8 CDL01279.1 - 8.3e-21 74.3 0.0 1.5e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 Disulphide bond corrector protein DsbC Thioredoxin_7 PF13899.6 CDL01279.1 - 3.6e-13 49.5 0.0 6.5e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like DsbD PF02683.15 CDL01279.1 - 2.9e-07 30.6 16.0 4.8e-07 29.9 16.0 1.3 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region Thioredox_DsbH PF03190.15 CDL01279.1 - 0.018 15.0 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Thioredoxin PF00085.20 CDL01279.1 - 0.15 12.1 0.1 0.25 11.3 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin Response_reg PF00072.24 CDL01280.1 - 2.8e-24 85.4 0.1 7e-24 84.2 0.0 1.7 2 0 0 2 2 2 1 Response regulator receiver domain cNMP_binding PF00027.29 CDL01280.1 - 2.3e-21 75.6 0.0 3.8e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain SCP2 PF02036.17 CDL01281.1 - 4e-11 43.3 0.0 6.2e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 SCP-2 sterol transfer family WD40_alt PF14077.6 CDL01281.1 - 0.0071 16.2 0.1 0.016 15.1 0.1 1.5 1 0 0 1 1 1 1 Alternative WD40 repeat motif Alkyl_sulf_C PF14864.6 CDL01281.1 - 0.06 13.6 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal Peptidase_U32 PF01136.19 CDL01282.1 - 2.1e-61 207.0 0.0 2.7e-61 206.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family U32 DUF5619 PF18505.1 CDL01282.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5619) Peptidase_U32 PF01136.19 CDL01283.1 - 5.5e-18 65.0 0.0 6.3e-17 61.5 0.0 1.9 1 1 1 2 2 2 2 Peptidase family U32 Flagellar_rod PF05149.12 CDL01284.1 - 0.0073 15.8 2.6 0.02 14.3 2.5 1.7 1 1 0 1 1 1 1 Paraflagellar rod protein HMGL-like PF00682.19 CDL01284.1 - 0.06 12.9 0.2 0.13 11.8 0.1 1.4 1 1 0 1 1 1 0 HMGL-like Fib_alpha PF08702.10 CDL01284.1 - 0.077 13.2 1.1 0.15 12.2 1.1 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Ebp2 PF05890.12 CDL01284.1 - 0.13 11.8 0.4 0.18 11.3 0.4 1.3 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 ACCA PF03255.14 CDL01284.1 - 0.17 11.8 1.5 0.5 10.2 0.5 2.0 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DDE_3 PF13358.6 CDL01285.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL01285.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDL01286.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL01286.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL01286.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL01286.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL01286.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL01286.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain NTP_transferase PF00483.23 CDL01287.1 - 9.3e-29 100.7 0.0 1.2e-28 100.4 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CDL01287.1 - 1.3e-07 32.1 0.1 2.1e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 CDL01287.1 - 0.024 14.4 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase DUF4926 PF16277.5 CDL01288.1 - 0.089 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4926) CobT_C PF11775.8 CDL01289.1 - 4.2e-108 360.0 0.1 6.1e-108 359.5 0.1 1.2 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT VWA domain CobT PF06213.12 CDL01289.1 - 1.4e-85 287.0 9.6 2.4e-85 286.3 9.6 1.3 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT VWA PF00092.28 CDL01289.1 - 0.007 16.6 0.0 0.03 14.6 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CDL01289.1 - 0.016 15.8 0.0 1.3 9.7 0.0 2.9 2 0 0 2 2 2 0 von Willebrand factor type A domain CobS_N PF12556.8 CDL01290.1 - 3.9e-16 58.4 0.4 7.3e-16 57.6 0.4 1.5 1 0 0 1 1 1 1 Cobaltochelatase CobS subunit N terminal AAA_5 PF07728.14 CDL01290.1 - 3.2e-11 43.4 0.0 5.5e-11 42.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CDL01290.1 - 0.00024 21.6 0.0 0.00044 20.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CDL01290.1 - 0.003 17.7 0.0 0.0058 16.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain CbbQ_C PF08406.10 CDL01290.1 - 0.0076 16.5 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 CbbQ/NirQ/NorQ C-terminal AAA_3 PF07726.11 CDL01290.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDL01290.1 - 0.021 15.3 0.0 0.038 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDL01290.1 - 0.029 14.8 0.0 0.089 13.2 0.0 1.7 1 1 1 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 CDL01290.1 - 0.099 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF3512 PF12024.8 CDL01290.1 - 0.13 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3512) DnaJ PF00226.31 CDL01291.1 - 4.1e-14 52.4 0.9 2.7e-13 49.8 0.0 2.4 3 0 0 3 3 3 1 DnaJ domain sCache_2 PF17200.4 CDL01292.1 - 4.1e-43 146.9 0.1 1.4e-42 145.2 0.1 1.9 1 0 0 1 1 1 1 Single Cache domain 2 dCache_2 PF08269.11 CDL01292.1 - 5.3e-35 121.0 0.2 2.3e-34 118.9 0.0 2.0 2 0 0 2 2 2 1 Cache domain MCPsignal PF00015.21 CDL01292.1 - 1.1e-30 106.7 47.6 2.4e-29 102.3 25.6 3.1 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain Cache_3-Cache_2 PF17201.4 CDL01292.1 - 7.2e-11 41.9 0.0 7.2e-11 41.9 0.0 3.0 3 1 1 4 4 4 1 Cache 3/Cache 2 fusion domain HAMP PF00672.25 CDL01292.1 - 2.9e-09 37.1 0.7 2.9e-09 37.1 0.7 4.3 5 0 0 5 5 5 1 HAMP domain DUF948 PF06103.11 CDL01292.1 - 0.00035 20.8 24.2 0.95 9.8 3.2 6.2 4 2 2 6 6 6 3 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 CDL01292.1 - 0.0019 18.2 9.2 2 8.5 0.6 4.1 2 2 2 4 4 4 2 Protein of unknown function (DUF1664) HMMR_C PF15908.5 CDL01292.1 - 0.042 14.1 0.3 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal BLOC1_2 PF10046.9 CDL01292.1 - 0.24 11.7 6.4 14 6.1 0.2 4.1 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_13 PF13166.6 CDL01292.1 - 0.29 9.7 9.8 0.36 9.4 9.3 1.4 1 1 0 1 1 1 0 AAA domain TACC_C PF05010.14 CDL01292.1 - 1.3 8.8 4.3 1.5 8.6 0.1 2.6 2 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Laminin_II PF06009.12 CDL01292.1 - 2.5 8.1 23.2 1.6 8.7 4.8 3.9 3 2 1 4 4 4 0 Laminin Domain II SNARE PF05739.19 CDL01292.1 - 5.3 7.1 6.2 0.93 9.5 0.2 3.0 2 0 0 2 2 2 0 SNARE domain GldM_N PF12081.8 CDL01292.1 - 6.9 6.7 12.3 6.1 6.9 0.7 3.3 1 1 2 3 3 3 0 GldM N-terminal domain BolA PF01722.18 CDL01293.1 - 1.8e-33 114.7 0.8 2.1e-33 114.4 0.8 1.1 1 0 0 1 1 1 1 BolA-like protein Hemerythrin PF01814.23 CDL01294.1 - 8.9e-17 61.9 6.1 8.9e-17 61.9 6.1 1.4 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain DUF641 PF04859.12 CDL01294.1 - 0.09 13.1 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) APG6_N PF17675.1 CDL01294.1 - 0.15 12.6 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Oxidored_FMN PF00724.20 CDL01295.1 - 1.6e-77 261.1 0.0 1.9e-77 260.9 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family MCPsignal PF00015.21 CDL01296.1 - 2.2e-31 109.0 24.4 2.2e-31 109.0 24.4 3.0 2 2 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDL01296.1 - 1.1e-09 38.5 0.1 1.1e-09 38.5 0.1 4.3 4 1 0 4 4 3 1 HAMP domain 4HB_MCP_1 PF12729.7 CDL01296.1 - 0.00011 21.8 0.0 0.00011 21.8 0.0 3.5 4 0 0 4 4 4 1 Four helix bundle sensory module for signal transduction CHASE3 PF05227.13 CDL01296.1 - 0.0023 17.8 10.1 0.0023 17.8 10.1 4.2 2 1 3 5 5 5 1 CHASE3 domain DUF3450 PF11932.8 CDL01296.1 - 0.011 15.0 1.6 0.011 15.0 1.6 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 CDL01296.1 - 0.039 14.0 7.9 0.61 10.1 0.4 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) FGase PF05013.12 CDL01296.1 - 0.2 11.8 6.2 0.12 12.6 0.5 2.3 2 0 0 2 2 2 0 N-formylglutamate amidohydrolase PIN_8 PF18476.1 CDL01296.1 - 0.28 11.0 7.8 0.19 11.6 0.1 3.2 2 1 2 4 4 4 0 PIN like domain PilM PF07419.12 CDL01296.1 - 0.46 10.6 3.8 2.3 8.4 0.2 3.4 4 0 0 4 4 4 0 PilM DUF948 PF06103.11 CDL01296.1 - 1.5 9.2 25.0 0.46 10.8 3.0 5.2 4 2 2 6 6 6 0 Bacterial protein of unknown function (DUF948) SesA PF17107.5 CDL01296.1 - 3.6 7.8 13.7 0.43 10.8 1.3 3.5 2 1 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases CM_2 PF01817.21 CDL01297.1 - 3e-17 62.7 1.5 3.5e-17 62.5 1.5 1.1 1 0 0 1 1 1 1 Chorismate mutase type II GCS2 PF04107.13 CDL01298.1 - 2.6e-100 335.5 0.0 2.3e-99 332.4 0.0 1.9 2 0 0 2 2 2 1 Glutamate-cysteine ligase family 2(GCS2) EXS PF03124.14 CDL01298.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 EXS family Response_reg PF00072.24 CDL01299.1 - 4.4e-29 100.9 0.2 6.3e-29 100.4 0.2 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDL01299.1 - 4e-21 74.9 0.0 1.3e-20 73.2 0.0 1.9 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal ATP-synt_ab PF00006.25 CDL01300.1 - 5.6e-75 251.6 0.0 7.1e-75 251.3 0.0 1.1 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain T3SS_ATPase_C PF18269.1 CDL01300.1 - 8.2e-21 73.6 0.3 1.4e-20 72.9 0.3 1.4 1 0 0 1 1 1 1 T3SS EscN ATPase C-terminal domain ABC_tran PF00005.27 CDL01300.1 - 0.0048 17.4 0.0 0.011 16.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ATP-synt_ab_N PF02874.23 CDL01300.1 - 0.03 14.8 0.2 0.096 13.2 0.2 1.9 1 1 1 2 2 2 0 ATP synthase alpha/beta family, beta-barrel domain RsgA_GTPase PF03193.16 CDL01300.1 - 0.038 13.9 0.1 0.066 13.1 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase FliJ PF02050.16 CDL01301.1 - 2.5e-05 24.5 17.6 5.1e-05 23.5 17.2 1.8 1 1 1 2 2 2 1 Flagellar FliJ protein HAT_KAT11 PF08214.11 CDL01301.1 - 0.001 18.4 1.7 0.0013 18.1 1.7 1.1 1 0 0 1 1 1 1 Histone acetylation protein GAGA_bind PF06217.12 CDL01301.1 - 0.081 13.2 2.5 0.085 13.1 2.5 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family SAE2 PF08573.10 CDL01301.1 - 1.6 9.8 6.6 4.8 8.3 6.6 1.8 1 1 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Phage_holin_3_6 PF07332.11 CDL01301.1 - 1.8 8.6 3.8 8.5 6.5 0.1 2.5 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III SBP_bac_3 PF00497.20 CDL01302.1 - 3.3e-17 62.7 0.0 3.9e-17 62.4 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 FtsJ PF01728.19 CDL01303.1 - 1.7e-09 38.1 0.0 2.4e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 CDL01303.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F GAT PF03127.14 CDL01304.1 - 0.021 15.1 0.1 0.091 13.1 0.1 2.1 1 0 0 1 1 1 0 GAT domain Nucleos_tra2_C PF07662.13 CDL01305.1 - 1.8e-67 227.2 9.8 1.8e-67 227.2 9.8 1.9 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CDL01305.1 - 5e-21 75.1 5.7 5e-21 75.1 5.7 2.5 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 CDL01305.1 - 3.5e-05 24.0 6.9 3.5e-05 24.0 6.9 3.1 3 1 0 3 3 3 1 Nucleoside recognition PepSY_TM_like_2 PF16357.5 CDL01305.1 - 7.6 6.5 7.2 4.3 7.3 1.2 2.2 2 0 0 2 2 2 0 Putative PepSY_TM-like EAL PF00563.20 CDL01306.1 - 1.2e-76 257.4 0.1 2.7e-76 256.3 0.1 1.7 1 0 0 1 1 1 1 EAL domain GGDEF PF00990.21 CDL01306.1 - 1e-37 129.4 0.0 2.1e-37 128.3 0.0 1.6 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_4 PF08448.10 CDL01306.1 - 1.7e-31 108.7 3.4 1.8e-14 53.9 0.2 4.6 4 0 0 4 4 4 3 PAS fold PAS PF00989.25 CDL01306.1 - 8.5e-30 103.1 0.0 1.1e-13 51.2 0.0 3.8 3 0 0 3 3 3 3 PAS fold PAS_9 PF13426.7 CDL01306.1 - 4.9e-27 94.2 0.0 4.7e-13 49.3 0.0 3.5 3 0 0 3 3 3 3 PAS domain PAS_8 PF13188.7 CDL01306.1 - 5.5e-20 70.9 3.2 7.6e-08 32.2 0.0 5.0 4 1 0 4 4 4 3 PAS domain Response_reg PF00072.24 CDL01306.1 - 2.3e-10 40.6 0.5 2.4e-09 37.3 0.1 2.6 2 0 0 2 2 2 1 Response regulator receiver domain PAS_3 PF08447.12 CDL01306.1 - 5.4e-09 36.2 0.0 0.044 14.1 0.0 3.7 3 0 0 3 3 3 2 PAS fold HisKA PF00512.25 CDL01306.1 - 2.1e-07 30.9 5.3 2.4e-07 30.7 0.0 3.7 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 CDL01307.1 - 5e-22 78.2 0.1 5.6e-22 78.0 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain TrmE_N PF10396.9 CDL01307.1 - 0.19 12.1 0.0 0.66 10.3 0.0 1.8 1 1 1 2 2 2 0 GTP-binding protein TrmE N-terminus Sel1 PF08238.12 CDL01308.1 - 1.6e-25 88.9 24.9 9.9e-06 26.1 0.1 8.4 8 0 0 8 8 8 8 Sel1 repeat Pterin_4a PF01329.19 CDL01309.1 - 2.3e-29 101.4 0.0 2.6e-29 101.3 0.0 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Zincin_1 PF06262.11 CDL01310.1 - 6.4e-33 112.7 0.1 9.5e-33 112.2 0.1 1.2 1 0 0 1 1 1 1 Zincin-like metallopeptidase Peptidase_M57 PF12388.8 CDL01310.1 - 0.14 11.8 0.5 0.19 11.3 0.5 1.1 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_2 PF13574.6 CDL01310.1 - 0.27 11.1 0.3 0.37 10.6 0.3 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like AAA_32 PF13654.6 CDL01311.1 - 4.5e-200 665.8 0.0 5.4e-200 665.5 0.0 1.0 1 0 0 1 1 1 1 AAA domain Lon_C PF05362.13 CDL01311.1 - 2.3e-09 37.1 0.0 5.1e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain Mg_chelatase PF01078.21 CDL01311.1 - 0.064 12.6 0.0 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Paz_1 PF18349.1 CDL01311.1 - 0.2 11.7 0.2 0.98 9.4 0.0 2.2 3 0 0 3 3 3 0 PAZ domain Iso_dh PF00180.20 CDL01313.1 - 1.8e-76 257.6 0.0 2e-76 257.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phe_ZIP PF08916.11 CDL01313.1 - 0.038 14.7 0.1 0.12 13.1 0.0 1.9 2 0 0 2 2 2 0 Phenylalanine zipper Cytochrom_C_2 PF01322.20 CDL01314.1 - 6.7e-27 94.8 0.2 8.7e-27 94.4 0.2 1.2 1 0 0 1 1 1 1 Cytochrome C' Cytochrom_B562 PF07361.11 CDL01314.1 - 0.0044 17.7 0.0 0.0084 16.7 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b562 Abhydrolase_6 PF12697.7 CDL01315.1 - 5e-09 37.1 4.5 6.7e-09 36.7 4.5 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDL01315.1 - 1.8e-07 30.7 0.2 4.9e-07 29.3 0.2 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DLH PF01738.18 CDL01315.1 - 3.1e-07 30.2 0.5 6.6e-06 25.8 0.5 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family DUF3530 PF12048.8 CDL01315.1 - 0.00054 19.5 0.5 0.00098 18.6 0.4 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF3530) Abhydrolase_1 PF00561.20 CDL01315.1 - 0.0014 18.4 0.1 0.0022 17.7 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF1749 PF08538.10 CDL01315.1 - 0.0042 16.2 0.0 0.0085 15.2 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_5 PF12695.7 CDL01315.1 - 0.0047 16.7 0.0 0.0073 16.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 CDL01315.1 - 0.029 14.2 0.3 0.045 13.6 0.3 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CDL01315.1 - 0.21 11.4 0.0 0.78 9.5 0.0 1.7 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Ni_hydr_CYTB PF01292.20 CDL01316.1 - 5e-24 84.9 12.8 5e-24 84.9 12.8 1.8 2 1 0 2 2 2 1 Prokaryotic cytochrome b561 DUF4405 PF14358.6 CDL01316.1 - 0.045 14.3 4.6 0.045 14.3 4.6 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4405) Big_6 PF17936.1 CDL01317.1 - 8.9e-11 41.9 2.4 0.00018 21.7 0.3 2.8 2 1 0 2 2 2 2 Bacterial Ig domain LysM PF01476.20 CDL01317.1 - 5.1e-09 36.1 0.0 9.1e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 LysM domain CarboxypepD_reg PF13620.6 CDL01317.1 - 0.012 15.9 2.5 1.9 8.8 0.1 2.6 2 1 0 2 2 2 0 Carboxypeptidase regulatory-like domain Big_3_5 PF16640.5 CDL01317.1 - 0.013 15.7 4.8 1.6 9.0 0.4 2.9 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) PS_Dcarbxylase PF02666.15 CDL01319.1 - 6.8e-33 113.9 0.0 1.1e-27 96.9 0.0 2.0 2 0 0 2 2 2 2 Phosphatidylserine decarboxylase Biotin_lipoyl_2 PF13533.6 CDL01319.1 - 0.1 12.4 0.0 0.37 10.6 0.0 1.9 2 0 0 2 2 2 0 Biotin-lipoyl like DUF4131 PF13567.6 CDL01319.1 - 0.11 12.2 0.6 0.19 11.4 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) CDP-OH_P_transf PF01066.21 CDL01320.1 - 4.6e-13 49.7 0.3 4.6e-13 49.7 0.3 3.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase CDP-OH_P_tran_2 PF08009.11 CDL01320.1 - 4.5e-12 45.6 13.4 4.5e-12 45.6 13.4 3.2 3 0 0 3 3 3 1 CDP-alcohol phosphatidyltransferase 2 ABC2_membrane_5 PF13346.6 CDL01320.1 - 0.1 12.1 7.8 1.6 8.3 6.3 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein OMP_b-brl PF13505.6 CDL01321.1 - 1.1e-21 77.8 15.7 1.7e-21 77.2 15.7 1.2 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OmpA PF00691.20 CDL01321.1 - 9.2e-21 74.0 0.0 1.4e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 OmpA family Surface_Ag_2 PF01617.17 CDL01321.1 - 2.3e-12 46.9 0.6 9.7e-09 35.0 0.0 2.4 1 1 1 2 2 2 2 Surface antigen Opacity PF02462.15 CDL01321.1 - 2.5e-07 30.9 0.4 6e-07 29.6 0.4 1.7 1 0 0 1 1 1 1 Opacity family porin protein PagL PF09411.10 CDL01321.1 - 1.2e-06 28.7 2.5 3.5e-05 24.0 0.3 2.2 1 1 0 2 2 2 1 Lipid A 3-O-deacylase (PagL) OmpA_membrane PF01389.17 CDL01321.1 - 0.00072 19.3 1.1 0.00072 19.3 1.1 2.7 2 1 0 2 2 2 1 OmpA-like transmembrane domain OmpW PF03922.14 CDL01321.1 - 0.00086 19.2 0.2 0.003 17.5 0.3 1.8 2 0 0 2 2 2 1 OmpW family TonB_N PF16031.5 CDL01321.1 - 0.0013 19.3 4.6 0.0022 18.5 4.6 1.3 1 0 0 1 1 1 1 TonB polyproline region DEC-1_N PF04625.13 CDL01321.1 - 0.0021 17.2 2.0 0.0027 16.8 2.0 1.2 1 0 0 1 1 1 1 DEC-1 protein, N-terminal region PhageMin_Tail PF10145.9 CDL01321.1 - 0.049 13.5 0.1 0.083 12.7 0.1 1.3 1 0 0 1 1 1 0 Phage-related minor tail protein Lamprin PF06403.11 CDL01321.1 - 0.98 9.4 9.4 0.27 11.2 4.4 2.2 1 1 1 2 2 2 0 Lamprin FMN_bind_2 PF04299.12 CDL01322.1 - 4.4e-60 202.2 0.0 5.2e-60 202.0 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain PseudoU_synth_1 PF01416.20 CDL01322.1 - 0.17 12.4 0.0 1 9.9 0.0 2.0 1 1 1 2 2 2 0 tRNA pseudouridine synthase Lipase_GDSL_2 PF13472.6 CDL01323.1 - 3.5e-19 69.9 0.9 4e-19 69.7 0.9 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CDL01323.1 - 3.3e-08 33.7 0.0 2.8e-05 24.2 0.0 2.0 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase PepSY_2 PF13670.6 CDL01324.1 - 0.022 14.7 0.2 0.022 14.7 0.2 2.3 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Glyco_transf_4 PF13439.6 CDL01325.1 - 1.8e-17 63.9 3.0 7.2e-17 61.9 3.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CDL01325.1 - 2.6e-13 50.6 0.0 5.1e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDL01325.1 - 7.2e-13 48.4 0.0 9.8e-12 44.7 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDL01325.1 - 1e-08 35.8 11.3 4.4e-08 33.7 8.8 2.7 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Asp_Glu_race PF01177.22 CDL01326.1 - 5.4e-30 104.9 0.1 6.6e-30 104.6 0.1 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase PK_C PF02887.16 CDL01326.1 - 0.088 13.0 0.0 11 6.3 0.0 2.4 2 1 0 2 2 2 0 Pyruvate kinase, alpha/beta domain DUF2000 PF09391.10 CDL01326.1 - 0.15 12.0 0.7 0.46 10.4 0.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2000) MH2 PF03166.14 CDL01327.1 - 0.036 14.3 0.0 0.055 13.7 0.0 1.2 1 0 0 1 1 1 0 MH2 domain UBA_6 PF18039.1 CDL01327.1 - 0.15 12.0 0.1 1.2 9.1 0.1 2.2 2 0 0 2 2 2 0 UBA-like domain MFS_1 PF07690.16 CDL01328.1 - 1.3e-26 93.4 47.8 3.1e-22 79.0 40.3 2.4 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDL01328.1 - 5.9e-08 32.0 6.1 5.9e-08 32.0 6.1 3.8 4 1 1 5 5 5 1 Sugar (and other) transporter sCache_3_2 PF17203.4 CDL01328.1 - 7.6e-05 22.9 0.1 0.00022 21.3 0.1 1.8 1 0 0 1 1 1 1 Single cache domain 3 HAMP PF00672.25 CDL01328.1 - 0.0058 17.0 0.0 0.029 14.7 0.0 2.2 2 0 0 2 2 2 1 HAMP domain ABC_sub_bind PF04392.12 CDL01329.1 - 2.3e-28 99.3 0.0 3.1e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 ABC transporter substrate binding protein Formyl_trans_N PF00551.19 CDL01330.1 - 2e-15 57.0 0.0 3.7e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase SpoIIE PF07228.12 CDL01331.1 - 6.6e-50 169.7 0.2 1.3e-49 168.8 0.2 1.5 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) HATPase_c_2 PF13581.6 CDL01331.1 - 1.6e-20 73.3 0.0 3.4e-20 72.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HAMP PF00672.25 CDL01331.1 - 2.1e-09 37.6 5.0 2.8e-05 24.4 0.0 3.5 3 0 0 3 3 3 2 HAMP domain dCache_3 PF14827.6 CDL01331.1 - 1e-05 25.3 0.1 1e-05 25.3 0.1 2.4 2 1 0 2 2 2 1 Double sensory domain of two-component sensor kinase dCache_1 PF02743.18 CDL01331.1 - 6.9e-05 22.7 0.0 0.00034 20.5 0.0 2.1 2 1 0 2 2 2 1 Cache domain PAS_4 PF08448.10 CDL01331.1 - 0.033 14.5 1.5 0.27 11.5 0.0 3.3 4 0 0 4 4 4 0 PAS fold Golgin_A5 PF09787.9 CDL01331.1 - 0.52 9.7 8.6 0.83 9.1 8.6 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 STAS_2 PF13466.6 CDL01332.1 - 3.1e-10 40.3 0.0 4.1e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 STAS domain STAS PF01740.21 CDL01332.1 - 1.1e-09 37.9 0.0 1.2e-09 37.8 0.0 1.0 1 0 0 1 1 1 1 STAS domain Scm3 PF10384.9 CDL01333.1 - 0.13 12.0 1.2 1.6 8.6 0.1 2.2 1 1 1 2 2 2 0 Centromere protein Scm3 DDE_3 PF13358.6 CDL01334.1 - 1.1e-31 109.5 0.0 1.3e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CDL01334.1 - 0.085 13.1 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain HTH_Tnp_IS630 PF01710.16 CDL01335.1 - 1.1e-08 35.1 0.0 1.3e-08 34.9 0.0 1.1 1 0 0 1 1 1 1 Transposase HTH_33 PF13592.6 CDL01335.1 - 1.8e-05 24.3 0.0 3.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 CDL01335.1 - 0.0002 21.4 0.1 0.0004 20.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 CDL01335.1 - 0.00034 21.2 0.3 0.0087 16.7 0.3 2.1 1 1 1 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 CDL01335.1 - 0.0017 18.4 0.1 0.0025 17.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 CDL01335.1 - 0.011 15.5 0.1 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain CHASE PF03924.13 CDL01336.1 - 4.7e-49 166.9 0.7 1.2e-48 165.5 0.3 1.9 2 0 0 2 2 2 1 CHASE domain HATPase_c PF02518.26 CDL01336.1 - 1.5e-21 77.0 0.0 2.1e-19 70.1 0.0 2.3 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDL01336.1 - 1.9e-08 34.2 0.8 6.8e-08 32.4 0.0 2.3 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 CDL01336.1 - 0.032 14.1 0.0 0.088 12.7 0.0 1.6 2 0 0 2 2 2 0 GHKL domain SBP_bac_3 PF00497.20 CDL01337.1 - 8.4e-09 35.2 0.0 3.5e-08 33.2 0.0 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 SPOR PF05036.13 CDL01337.1 - 0.0051 17.2 0.1 0.012 15.9 0.0 1.6 2 0 0 2 2 2 1 Sporulation related domain PGM1_C PF18105.1 CDL01337.1 - 0.096 12.2 0.1 0.36 10.4 0.0 1.9 2 0 0 2 2 2 0 PGM1 C-terminal domain DDE_Tnp_IS66 PF03050.14 CDL01338.1 - 4e-35 121.7 0.1 4.9e-35 121.4 0.1 1.1 1 0 0 1 1 1 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDL01338.1 - 5.5e-19 68.1 0.1 1.1e-18 67.2 0.1 1.5 1 0 0 1 1 1 1 IS66 C-terminal element Bombinin PF05298.11 CDL01338.1 - 0.15 11.8 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Bombinin DUF3461 PF11944.8 CDL01339.1 - 0.029 14.5 0.6 0.14 12.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3461) RVT_1 PF00078.27 CDL01340.1 - 1.8e-24 86.5 0.0 2.3e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF772 PF05598.11 CDL01341.1 - 1.9e-20 72.6 0.0 4.1e-20 71.6 0.0 1.6 1 0 0 1 1 1 1 Transposase domain (DUF772) DDE_Tnp_1 PF01609.21 CDL01341.1 - 2.2e-12 47.1 1.7 3.9e-12 46.3 1.7 1.4 1 1 0 1 1 1 1 Transposase DDE domain DDE_Tnp_4 PF13359.6 CDL01341.1 - 0.011 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_Tnp_1_6 PF13751.6 CDL01341.1 - 0.18 12.0 0.1 0.37 11.0 0.1 1.5 1 0 0 1 1 1 0 Transposase DDE domain HTH_9 PF08221.11 CDL01342.1 - 0.014 15.5 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain DUF724 PF05266.14 CDL01344.1 - 0.062 13.1 0.6 0.067 13.0 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DivIC PF04977.15 CDL01344.1 - 0.21 11.4 1.9 2.8 7.8 0.3 2.0 1 1 1 2 2 2 0 Septum formation initiator IMS PF00817.20 CDL01345.1 - 2.8e-45 154.0 0.0 4.7e-45 153.2 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CDL01345.1 - 1.1e-21 77.7 0.1 9.3e-21 74.7 0.0 2.1 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain DNA_pol_lambd_f PF10391.9 CDL01345.1 - 0.00043 20.0 0.1 0.00089 19.0 0.1 1.4 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda IMS_HHH PF11798.8 CDL01345.1 - 0.0021 18.3 0.0 0.0058 16.9 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif DUF4332 PF14229.6 CDL01345.1 - 0.014 15.6 0.0 0.046 14.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) HHH_5 PF14520.6 CDL01345.1 - 0.087 13.5 0.1 0.27 11.9 0.1 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain YbjQ_1 PF01906.17 CDL01347.1 - 4.5e-38 130.1 2.2 4.9e-38 129.9 2.2 1.0 1 0 0 1 1 1 1 Putative heavy-metal-binding Fe-ADH PF00465.19 CDL01347.1 - 0.047 12.5 0.0 0.056 12.2 0.0 1.0 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase 3Beta_HSD PF01073.19 CDL01348.1 - 8.7e-19 67.6 0.0 1.7e-14 53.5 0.0 3.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CDL01348.1 - 1.3e-17 64.0 0.0 5.5e-17 62.0 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDL01348.1 - 3.5e-16 59.1 0.0 6.9e-14 51.6 0.0 3.0 2 1 0 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 CDL01348.1 - 5.5e-15 55.7 3.5 1e-14 54.9 3.5 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CDL01348.1 - 1.3e-14 54.3 0.8 4.3e-13 49.4 1.8 2.0 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 CDL01348.1 - 1e-06 28.3 0.5 1.7e-06 27.6 0.3 1.4 1 1 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 CDL01348.1 - 0.00059 19.1 0.0 0.0051 16.0 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 CDL01348.1 - 0.0037 17.5 0.2 0.0089 16.3 0.2 1.7 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short_C2 PF13561.6 CDL01348.1 - 0.0083 15.7 1.5 0.03 13.9 1.5 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase GDP_Man_Dehyd PF16363.5 CDL01348.1 - 0.074 12.4 0.1 0.15 11.4 0.0 1.6 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CDL01348.1 - 0.18 10.9 1.4 1.6 7.8 1.4 2.0 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein DNA_pol_A_exo1 PF01612.20 CDL01349.1 - 6e-38 130.3 0.0 7.2e-38 130.0 0.0 1.0 1 0 0 1 1 1 1 3'-5' exonuclease SIS PF01380.22 CDL01350.1 - 1.6e-26 92.7 0.2 2.7e-26 92.0 0.2 1.3 1 0 0 1 1 1 1 SIS domain CBS PF00571.28 CDL01350.1 - 2.3e-17 63.2 4.6 1.4e-10 41.4 0.1 3.4 4 1 0 4 4 4 2 CBS domain SIS_2 PF13580.6 CDL01350.1 - 0.062 13.3 0.0 0.17 11.9 0.0 1.7 1 1 1 2 2 2 0 SIS domain LptC PF06835.13 CDL01351.1 - 1.8e-12 47.2 0.0 2.3e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide-assembly, LptC-related RskA PF10099.9 CDL01351.1 - 0.022 15.0 0.3 0.031 14.6 0.2 1.3 1 1 0 1 1 1 0 Anti-sigma-K factor rskA OstA PF03968.14 CDL01352.1 - 3.8e-16 59.3 2.9 1e-08 35.4 0.1 2.2 1 1 1 2 2 2 2 OstA-like protein LptC PF06835.13 CDL01352.1 - 2.8e-05 23.7 0.4 0.0097 15.5 0.0 2.8 3 1 0 3 3 3 2 Lipopolysaccharide-assembly, LptC-related DUF2460 PF09343.10 CDL01352.1 - 0.077 12.5 0.2 4.4 6.8 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical protein 2217 (DUF2460) ABC_tran PF00005.27 CDL01353.1 - 6.9e-33 114.1 0.0 9.8e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDL01353.1 - 2.3e-07 31.0 0.4 0.019 14.8 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system BCA_ABC_TP_C PF12399.8 CDL01353.1 - 0.00012 21.9 0.1 0.00024 21.0 0.1 1.6 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_23 PF13476.6 CDL01353.1 - 0.013 16.0 0.0 0.02 15.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 CDL01353.1 - 0.042 13.3 0.0 7.3 6.0 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDL01353.1 - 0.06 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_DBD PF04552.13 CDL01354.1 - 1.8e-68 229.3 0.2 3.2e-68 228.4 0.2 1.4 1 0 0 1 1 1 1 Sigma-54, DNA binding domain Sigma54_CBD PF04963.13 CDL01354.1 - 1.4e-48 165.1 0.0 2.9e-48 164.1 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 factor, core binding domain Sigma54_AID PF00309.20 CDL01354.1 - 1.4e-19 69.7 10.8 3.8e-19 68.3 10.8 1.8 1 0 0 1 1 1 1 Sigma-54 factor, Activator interacting domain (AID) HTH_23 PF13384.6 CDL01354.1 - 0.0077 16.0 0.4 3 7.8 0.0 3.3 3 1 0 3 3 3 1 Homeodomain-like domain HTH_3 PF01381.22 CDL01354.1 - 0.013 15.6 0.4 14 5.9 0.0 3.6 3 0 0 3 3 3 0 Helix-turn-helix Sigma70_r4_2 PF08281.12 CDL01354.1 - 0.027 14.1 0.1 3.8 7.3 0.0 2.8 2 0 0 2 2 2 0 Sigma-70, region 4 YdaS_antitoxin PF15943.5 CDL01354.1 - 0.03 14.2 0.0 0.29 11.0 0.0 2.4 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_38 PF13936.6 CDL01354.1 - 0.031 14.0 0.6 0.31 10.8 0.0 2.9 4 0 0 4 4 3 0 Helix-turn-helix domain HTH_IclR PF09339.10 CDL01354.1 - 0.031 14.1 0.2 0.88 9.4 0.0 2.6 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_11 PF08279.12 CDL01354.1 - 0.036 14.0 0.1 0.32 11.0 0.0 2.6 2 0 0 2 2 2 0 HTH domain Arg_repressor PF01316.21 CDL01354.1 - 0.041 13.6 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain HTH_AsnC-type PF13404.6 CDL01354.1 - 0.068 13.0 1.9 13 5.8 0.1 3.4 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain LacI PF00356.21 CDL01354.1 - 0.072 12.9 2.5 1.7 8.5 0.1 3.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family Phage_CII PF05269.11 CDL01354.1 - 0.082 13.1 0.1 4.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Bacteriophage CII protein MarR PF01047.22 CDL01354.1 - 0.14 12.1 0.2 16 5.5 0.0 2.9 3 0 0 3 3 3 0 MarR family DprA_WH PF17782.1 CDL01354.1 - 0.29 11.3 2.9 2.1 8.5 0.1 3.3 3 0 0 3 3 3 0 DprA winged helix domain PTS_EIIA_2 PF00359.22 CDL01355.1 - 1.3e-34 119.2 0.0 1.4e-34 119.0 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Band_3_cyto PF07565.13 CDL01355.1 - 0.15 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain GST_N_3 PF13417.6 CDL01356.1 - 1.6e-20 73.2 0.0 2.8e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDL01356.1 - 3.9e-15 55.9 0.0 1e-14 54.6 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDL01356.1 - 7.7e-10 39.0 0.0 1.5e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDL01356.1 - 3.8e-05 23.8 0.1 0.00012 22.2 0.1 1.9 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDL01356.1 - 6.1e-05 23.0 2.7 8.7e-05 22.5 1.8 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 CDL01356.1 - 9.1e-05 22.6 0.0 0.0018 18.4 0.0 2.4 2 0 0 2 2 2 1 Glutaredoxin GST_C_3 PF14497.6 CDL01356.1 - 0.00015 21.9 0.0 0.00054 20.1 0.0 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 CDL01356.1 - 0.0033 17.7 0.0 0.024 15.0 0.0 2.0 1 1 1 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 CDL01356.1 - 0.025 15.3 0.0 0.052 14.3 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain Polysacc_deac_1 PF01522.21 CDL01357.1 - 1.4e-24 86.4 0.0 2.1e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase NAD_binding_10 PF13460.6 CDL01357.1 - 0.099 12.5 0.0 1.2 9.0 0.0 2.2 1 1 1 2 2 2 0 NAD(P)H-binding Acetyltransf_1 PF00583.25 CDL01358.1 - 3.5e-12 46.6 0.0 4.3e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDL01358.1 - 6.7e-11 42.5 0.0 1.1e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDL01358.1 - 5.4e-09 36.1 0.0 7.4e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDL01358.1 - 0.098 12.6 0.0 0.31 11.0 0.0 1.8 2 0 0 2 2 2 0 FR47-like protein Ribul_P_3_epim PF00834.19 CDL01359.1 - 5.2e-84 280.6 0.2 5.9e-84 280.4 0.2 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family His_biosynth PF00977.21 CDL01359.1 - 0.00017 21.2 0.4 0.0022 17.5 0.3 2.1 1 1 1 2 2 2 1 Histidine biosynthesis protein TMP-TENI PF02581.17 CDL01359.1 - 0.00091 18.6 0.3 0.0015 17.9 0.3 1.4 1 0 0 1 1 1 1 Thiamine monophosphate synthase DHO_dh PF01180.21 CDL01359.1 - 0.0023 17.2 0.6 0.004 16.4 0.6 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase ThiG PF05690.14 CDL01359.1 - 0.0092 15.3 0.5 0.015 14.6 0.5 1.5 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 CDL01359.1 - 0.022 13.8 3.0 0.29 10.1 0.6 2.4 2 1 1 3 3 3 0 IMP dehydrogenase / GMP reductase domain NanE PF04131.14 CDL01359.1 - 0.054 12.7 0.5 0.14 11.3 0.5 1.8 1 1 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase F_bP_aldolase PF01116.20 CDL01360.1 - 1.7e-94 316.5 0.1 1.9e-94 316.3 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Amidohydro_2 PF04909.14 CDL01360.1 - 0.086 12.6 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Amidohydrolase AP_endonuc_2 PF01261.24 CDL01360.1 - 0.13 11.7 0.0 0.61 9.5 0.0 2.1 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel Transketolase_N PF00456.21 CDL01361.1 - 2.9e-132 440.7 0.2 4.2e-132 440.2 0.2 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CDL01361.1 - 1.1e-46 158.8 0.0 2.8e-46 157.4 0.0 1.7 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDL01361.1 - 1.1e-15 57.5 0.1 2.6e-15 56.4 0.1 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CDL01361.1 - 2.4e-08 33.6 0.0 9.2e-06 25.1 0.1 2.3 1 1 0 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 CDL01361.1 - 2.7e-07 30.5 3.5 6.1e-06 26.1 2.6 3.3 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 CDL01361.1 - 3.1e-05 23.1 1.0 5.5e-05 22.2 1.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component PRK PF00485.18 CDL01362.1 - 1.6e-32 112.8 0.0 2.8e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.12 CDL01362.1 - 0.00087 18.6 0.0 0.002 17.4 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 CDL01362.1 - 0.017 15.5 0.0 0.032 14.6 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 CDL01362.1 - 0.019 15.2 0.2 0.058 13.6 0.2 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDL01362.1 - 0.097 13.2 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 ABC transporter FBPase_glpX PF03320.13 CDL01363.1 - 3.5e-84 282.3 0.0 7.4e-84 281.2 0.0 1.5 1 1 0 1 1 1 1 Bacterial fructose-1,6-bisphosphatase, glpX-encoded Ni_hydr_CYTB PF01292.20 CDL01364.1 - 7.2e-29 100.7 11.7 8.9e-29 100.4 11.7 1.1 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 Cytochrom_B561 PF03188.16 CDL01364.1 - 0.017 15.2 0.6 0.017 15.2 0.6 2.0 2 1 0 2 2 2 0 Eukaryotic cytochrome b561 DUF4079 PF13301.6 CDL01364.1 - 0.056 13.6 0.2 0.056 13.6 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) GerE PF00196.19 CDL01365.1 - 3.4e-19 68.1 0.0 5.4e-19 67.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Response_reg PF00072.24 CDL01365.1 - 4.9e-16 58.9 0.0 6.5e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Sigma70_r4_2 PF08281.12 CDL01365.1 - 9.9e-06 25.1 0.0 1.8e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_20 PF12840.7 CDL01365.1 - 6.4e-05 22.9 0.1 0.00026 21.0 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.6 CDL01365.1 - 0.00017 21.1 0.0 0.00031 20.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Sigma70_r4 PF04545.16 CDL01365.1 - 0.0018 17.8 0.0 0.0039 16.7 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_10 PF04967.12 CDL01365.1 - 0.018 14.8 0.1 0.12 12.1 0.1 2.2 1 1 0 1 1 1 0 HTH DNA binding domain Hit1_C PF18268.1 CDL01365.1 - 0.15 12.2 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Hit1 C-terminal DUF2089 PF09862.9 CDL01365.1 - 0.2 11.7 0.0 0.31 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) EAL PF00563.20 CDL01366.1 - 1.2e-68 231.2 0.0 2.4e-68 230.2 0.0 1.4 2 0 0 2 2 2 1 EAL domain GGDEF PF00990.21 CDL01366.1 - 5.4e-49 166.0 0.0 9.3e-49 165.3 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain PAS_9 PF13426.7 CDL01366.1 - 1.8e-06 28.2 0.0 1.2e-05 25.4 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 CDL01366.1 - 0.05 13.8 0.0 0.2 11.9 0.0 2.1 1 1 0 1 1 1 0 PAS fold PAS_8 PF13188.7 CDL01366.1 - 0.14 12.2 0.0 1.9 8.6 0.0 2.6 2 0 0 2 2 2 0 PAS domain CHAP PF05257.16 CDL01367.1 - 3.4e-10 40.4 0.2 7.2e-10 39.3 0.2 1.5 1 0 0 1 1 1 1 CHAP domain NMT1_3 PF16868.5 CDL01368.1 - 7.1e-59 199.6 0.0 8.1e-59 199.4 0.0 1.0 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 CDL01368.1 - 2.8e-09 37.2 0.0 9.1e-09 35.6 0.0 1.8 1 1 1 2 2 2 1 NMT1/THI5 like Phosphonate-bd PF12974.7 CDL01368.1 - 1.7e-06 27.8 0.4 2.4e-06 27.4 0.4 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1_2 PF13379.6 CDL01368.1 - 2.5e-05 24.1 0.5 6.4e-05 22.8 0.5 1.7 1 1 0 1 1 1 1 NMT1-like family PBP_like PF12727.7 CDL01368.1 - 0.03 13.4 0.0 0.05 12.7 0.0 1.4 1 0 0 1 1 1 0 PBP superfamily domain YhfZ_C PF14503.6 CDL01368.1 - 0.04 13.4 0.0 0.1 12.1 0.0 1.6 1 1 0 1 1 1 0 YhfZ C-terminal domain PBP_like_2 PF12849.7 CDL01368.1 - 0.076 12.7 0.2 0.35 10.5 0.1 1.9 2 0 0 2 2 2 0 PBP superfamily domain DUF4148 PF13663.6 CDL01368.1 - 7.5 6.8 8.8 17 5.7 0.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Cytochrom_C PF00034.21 CDL01370.1 - 9.6e-09 36.3 0.0 1.4e-08 35.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CDL01370.1 - 0.0013 19.0 4.3 0.011 16.1 4.3 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III CCP_MauG PF03150.14 CDL01370.1 - 0.12 13.0 0.0 0.14 12.8 0.0 1.1 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase LPAM_1 PF08139.12 CDL01370.1 - 1.9 9.1 5.0 4 8.1 5.0 1.5 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site HrpB_C PF08482.10 CDL01371.1 - 2.7e-54 183.2 0.1 5.1e-54 182.3 0.1 1.5 1 0 0 1 1 1 1 ATP-dependent helicase C-terminal HA2 PF04408.23 CDL01371.1 - 2.5e-12 47.0 0.0 5.8e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CDL01371.1 - 3.6e-12 46.6 0.0 6.5e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDL01371.1 - 1.8e-07 31.1 0.0 2.9e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 CDL01371.1 - 0.00012 22.0 0.0 0.0057 16.6 0.0 2.7 2 0 0 2 2 2 1 Flavivirus DEAD domain AAA_30 PF13604.6 CDL01371.1 - 0.051 13.3 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain SBP_bac_3 PF00497.20 CDL01372.1 - 6.3e-22 78.1 0.2 8.4e-22 77.7 0.2 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 MCPsignal PF00015.21 CDL01374.1 - 0.019 14.7 6.4 0.027 14.3 6.1 1.4 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TetR_C_15 PF17918.1 CDL01374.1 - 2.6 8.8 8.4 1.3 9.8 0.2 3.0 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain NnrS PF05940.12 CDL01375.1 - 0.58 9.5 55.3 6.2 6.1 55.1 2.3 1 1 0 1 1 1 0 NnrS protein DUF1129 PF06570.11 CDL01375.1 - 1.7 8.1 6.7 0.16 11.5 1.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) FeS_assembly_P PF01883.19 CDL01376.1 - 1.5e-13 50.7 0.2 4.7e-13 49.1 0.0 1.7 1 1 1 2 2 2 1 Iron-sulfur cluster assembly protein Abhydrolase_1 PF00561.20 CDL01377.1 - 1.1e-17 64.6 0.1 1.2e-17 64.5 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDL01377.1 - 3.2e-17 63.9 3.6 4.2e-17 63.5 3.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDL01377.1 - 1.4e-08 34.4 1.2 1.9e-08 33.9 1.2 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PEP-utilizers PF00391.23 CDL01377.1 - 0.025 14.3 0.1 0.051 13.3 0.1 1.5 1 0 0 1 1 1 0 PEP-utilising enzyme, mobile domain Glyoxalase_3 PF13468.6 CDL01378.1 - 7.2e-37 127.2 2.9 3.7e-36 124.9 1.5 2.0 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 CDL01378.1 - 1.1e-08 35.3 0.1 7.7e-06 26.1 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 CDL01378.1 - 0.042 14.0 0.2 0.61 10.3 0.0 2.5 2 1 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DUF3670 PF12419.8 CDL01378.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 SNF2 Helicase protein PDH PF02153.17 CDL01379.1 - 4.5e-77 258.6 0.0 5.1e-77 258.4 0.0 1.0 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.15 CDL01379.1 - 4.8e-05 23.6 0.3 0.00022 21.4 0.3 2.0 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CDL01379.1 - 0.0014 19.2 0.8 0.0029 18.2 0.8 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CDL01379.1 - 0.09 12.1 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Aminotran_1_2 PF00155.21 CDL01380.1 - 5.8e-51 173.8 0.0 7.1e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CDL01380.1 - 1.5e-05 24.5 0.0 2.2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CDL01380.1 - 0.00073 18.6 0.0 0.0011 17.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CDL01380.1 - 0.038 12.5 0.0 0.066 11.7 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Alliinase_C PF04864.13 CDL01380.1 - 0.14 11.0 0.0 0.25 10.2 0.0 1.4 1 0 0 1 1 1 0 Allinase CM_2 PF01817.21 CDL01381.1 - 9.3e-18 64.4 0.4 1.5e-17 63.7 0.4 1.3 1 0 0 1 1 1 1 Chorismate mutase type II Abhydrolase_1 PF00561.20 CDL01382.1 - 2.9e-31 109.1 0.3 3.9e-31 108.6 0.3 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDL01382.1 - 0.0055 16.0 0.0 0.0094 15.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 MetW PF07021.12 CDL01383.1 - 2e-82 275.5 0.0 2.2e-82 275.3 0.0 1.0 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_23 PF13489.6 CDL01383.1 - 1.5e-09 37.9 0.0 2.2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDL01383.1 - 3.9e-08 33.2 0.0 6.1e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDL01383.1 - 4.5e-08 33.6 0.1 9.1e-08 32.7 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL01383.1 - 5.6e-08 33.4 0.0 1.1e-07 32.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL01383.1 - 1.3e-06 29.0 0.0 2.8e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDL01383.1 - 0.0009 18.6 0.1 0.0012 18.2 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 CDL01383.1 - 0.0013 18.6 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDL01383.1 - 0.035 13.7 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TPMT PF05724.11 CDL01383.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) CoA_transf_3 PF02515.17 CDL01384.1 - 3.4e-52 177.8 1.0 9.4e-47 159.9 0.0 2.5 2 1 0 2 2 2 2 CoA-transferase family III PG_isomerase_N PF18353.1 CDL01384.1 - 0.095 13.1 0.4 0.31 11.5 0.1 1.9 2 0 0 2 2 2 0 Phosphoglucose isomerase N-terminal domain Methyltransf_11 PF08241.12 CDL01385.1 - 2.2e-09 37.8 0.0 5.1e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDL01385.1 - 1.7e-05 24.7 0.0 2.7e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL01385.1 - 5.4e-05 23.8 0.0 0.00013 22.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL01385.1 - 0.0025 18.5 0.0 0.0052 17.5 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDL01385.1 - 0.0035 16.7 0.0 0.005 16.2 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 CDL01385.1 - 0.01 15.7 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_31 PF13847.6 CDL01385.1 - 0.046 13.5 0.0 0.069 12.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 CDL01385.1 - 0.051 13.2 0.0 0.2 11.2 0.0 1.8 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Pox_MCEL PF03291.16 CDL01385.1 - 0.056 12.5 0.0 0.08 12.0 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme SOCS PF12610.8 CDL01385.1 - 0.096 13.1 0.1 0.2 12.0 0.1 1.5 1 0 0 1 1 1 0 Suppressor of cytokine signalling ABC2_membrane PF01061.24 CDL01386.1 - 1.2e-09 37.9 21.7 2.1e-09 37.1 21.7 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 CDL01386.1 - 0.00099 18.3 18.8 0.0012 18.1 18.8 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein CCB1 PF12046.8 CDL01386.1 - 0.0027 17.1 3.8 0.0047 16.3 3.8 1.3 1 0 0 1 1 1 1 Cofactor assembly of complex C subunit B ABC_tran PF00005.27 CDL01387.1 - 1.1e-28 100.5 0.0 1.5e-28 100.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDL01387.1 - 2.8e-10 40.5 1.8 3.8e-07 30.2 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system MukB PF04310.12 CDL01387.1 - 0.00028 20.8 0.6 0.00052 19.9 0.6 1.3 1 0 0 1 1 1 1 MukB N-terminal SMC_N PF02463.19 CDL01387.1 - 0.00033 20.1 0.0 0.079 12.4 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDL01387.1 - 0.012 15.4 1.3 0.022 14.5 1.3 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 CDL01387.1 - 0.024 14.8 0.1 0.12 12.6 0.1 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 CDL01387.1 - 0.027 14.1 0.1 0.047 13.3 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 CDL01387.1 - 0.049 12.9 0.0 0.18 11.0 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 CDL01387.1 - 0.056 13.9 0.0 0.084 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 CDL01387.1 - 0.077 12.6 0.2 0.15 11.7 0.3 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_19 PF13245.6 CDL01387.1 - 0.097 13.0 1.4 0.26 11.6 1.4 1.9 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDL01387.1 - 0.16 11.9 0.1 0.28 11.1 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_24 PF13479.6 CDL01387.1 - 0.17 11.6 0.0 1.9 8.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF4687 PF15747.5 CDL01388.1 - 0.052 14.0 0.1 0.12 12.9 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4687) TPR_2 PF07719.17 CDL01389.1 - 4.9e-19 66.8 11.0 0.0028 17.6 0.1 6.0 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 CDL01389.1 - 1.8e-15 56.0 1.5 0.015 15.1 0.0 5.9 6 0 0 6 6 6 5 Tetratricopeptide repeat ANAPC3 PF12895.7 CDL01389.1 - 2.3e-15 56.6 3.7 6.2e-06 26.3 0.0 3.3 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CDL01389.1 - 1.4e-13 51.1 10.7 0.00026 21.4 2.9 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDL01389.1 - 2.6e-13 49.6 26.2 0.018 15.8 0.0 6.0 2 2 4 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDL01389.1 - 2.1e-12 47.4 16.6 0.00097 19.7 0.8 4.1 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDL01389.1 - 4.3e-12 46.1 20.6 0.022 15.0 0.1 5.6 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 CDL01389.1 - 5e-11 41.9 0.1 0.0029 17.7 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDL01389.1 - 3.8e-07 30.1 24.1 0.00039 20.5 4.8 4.4 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDL01389.1 - 1.8e-05 25.1 9.7 0.43 11.3 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat NARP1 PF12569.8 CDL01389.1 - 2e-05 23.7 0.3 0.0046 15.9 0.1 2.7 1 1 2 3 3 3 1 NMDA receptor-regulated protein 1 TPR_7 PF13176.6 CDL01389.1 - 3.9e-05 23.4 4.9 3 8.1 0.0 4.7 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDL01389.1 - 4.5e-05 23.5 2.6 0.058 13.8 0.0 4.7 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDL01389.1 - 9e-05 21.8 10.8 0.0058 15.9 0.8 3.7 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDL01389.1 - 0.00015 21.5 18.8 0.028 14.3 0.2 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.14 CDL01389.1 - 0.0018 18.7 30.9 0.56 11.0 0.0 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat ChAPs PF09295.10 CDL01389.1 - 0.0066 15.5 0.2 0.0099 14.9 0.2 1.2 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) SRP_TPR_like PF17004.5 CDL01389.1 - 0.011 15.8 0.0 2.2 8.3 0.0 2.4 1 1 1 2 2 2 0 Putative TPR-like repeat HrpB1_HrpK PF09613.10 CDL01389.1 - 0.24 11.1 7.1 0.28 10.8 4.4 2.3 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) BTAD PF03704.17 CDL01389.1 - 2.1 8.8 16.4 3.5 8.1 7.4 2.7 1 1 2 3 3 3 0 Bacterial transcriptional activator domain Epimerase PF01370.21 CDL01390.1 - 2.5e-23 82.8 0.0 3.5e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDL01390.1 - 3.1e-15 56.4 0.0 4.7e-15 55.8 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CDL01390.1 - 1.6e-08 34.0 0.0 2.3e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 CDL01390.1 - 1.4e-07 31.3 0.0 2.6e-05 23.9 0.0 2.1 2 0 0 2 2 2 2 NmrA-like family 3Beta_HSD PF01073.19 CDL01390.1 - 2.1e-07 30.3 0.0 9e-07 28.2 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CDL01390.1 - 6.9e-06 25.4 0.0 4.6e-05 22.7 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CDL01390.1 - 7e-05 22.8 0.4 0.00017 21.5 0.1 1.8 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 CDL01390.1 - 0.023 13.8 0.2 0.093 11.9 0.3 1.9 2 0 0 2 2 2 0 Male sterility protein TrkA_N PF02254.18 CDL01390.1 - 0.026 14.8 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain GHMP_kinases_C PF08544.13 CDL01391.1 - 4.8e-09 36.5 0.1 1.4e-08 35.0 0.1 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 CDL01391.1 - 1.5e-08 34.8 1.1 2.6e-08 34.0 0.4 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain dTDP_sugar_isom PF00908.17 CDL01392.1 - 4e-51 173.0 0.0 4.5e-51 172.9 0.0 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase FdtA PF05523.11 CDL01392.1 - 0.027 14.2 0.0 0.066 12.9 0.0 1.5 1 1 0 1 1 1 0 WxcM-like, C-terminal Glycos_transf_2 PF00535.26 CDL01393.1 - 8.3e-14 51.8 0.0 1.2e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDL01393.1 - 1.2e-11 45.0 0.6 2.4e-11 44.0 0.5 1.6 1 1 1 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CDL01393.1 - 0.00015 21.4 0.0 0.00092 18.8 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Rhamno_transf PF11316.8 CDL01393.1 - 0.00075 18.9 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Putative rhamnosyl transferase Glyco_trans_2_3 PF13632.6 CDL01393.1 - 0.0046 16.9 0.1 0.0078 16.1 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 SIS_2 PF13580.6 CDL01393.1 - 0.06 13.4 0.0 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 SIS domain Glyco_transf_41 PF13844.6 CDL01394.1 - 3.1e-37 128.1 0.0 2.6e-22 78.9 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 41 TPR_19 PF14559.6 CDL01394.1 - 0.00051 20.5 23.7 0.072 13.6 0.8 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 CDL01394.1 - 0.024 14.3 0.1 0.081 12.6 0.1 1.9 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_20 PF14561.6 CDL01394.1 - 0.045 14.1 0.2 0.045 14.1 0.2 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Transketolase_N PF00456.21 CDL01395.1 - 5.9e-40 137.2 0.2 9.9e-40 136.5 0.2 1.3 1 1 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain DXP_synthase_N PF13292.6 CDL01395.1 - 9.2e-09 34.9 0.0 0.0022 17.3 0.0 3.1 2 1 1 3 3 3 3 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 CDL01395.1 - 5.3e-07 28.9 0.0 6.9e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 CDL01396.1 - 3.7e-25 88.6 0.1 6.1e-25 87.9 0.1 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDL01396.1 - 7e-20 71.2 0.2 1.3e-19 70.3 0.0 1.6 2 0 0 2 2 2 1 Transketolase, C-terminal domain PFOR_II PF17147.4 CDL01396.1 - 0.024 14.9 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II TPP_enzyme_N PF02776.18 CDL01396.1 - 0.042 13.5 0.6 0.18 11.4 0.6 2.1 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain DUF4072 PF13284.6 CDL01396.1 - 0.084 13.3 1.5 0.21 12.0 0.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4072) Radical_SAM PF04055.21 CDL01397.1 - 5e-09 36.8 0.0 1.1e-08 35.6 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily B12-binding PF02310.19 CDL01397.1 - 2.5e-08 34.0 0.0 5.2e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 B12 binding domain Epimerase PF01370.21 CDL01398.1 - 3.2e-46 157.7 0.0 4.3e-46 157.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDL01398.1 - 1.8e-16 60.5 0.0 2.3e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CDL01398.1 - 7.9e-07 28.4 0.0 8.8e-06 25.0 0.0 2.0 2 0 0 2 2 2 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CDL01398.1 - 4.9e-05 22.5 0.0 7.8e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CDL01398.1 - 0.0017 17.5 0.1 0.0033 16.6 0.1 1.4 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Aldo_ket_red PF00248.21 CDL01399.1 - 1.2e-62 211.8 0.0 1.3e-62 211.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TylF PF05711.11 CDL01400.1 - 2.1e-08 33.8 0.0 2.9e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.6 CDL01400.1 - 0.00022 22.2 0.0 0.00044 21.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL01401.1 - 0.083 13.6 0.0 0.15 12.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 CDL01401.1 - 0.14 12.8 0.1 0.46 11.2 0.1 1.9 1 1 1 2 2 2 0 Methyltransferase domain Carbam_trans_C PF16861.5 CDL01404.1 - 5.8e-56 188.7 0.0 1e-55 187.9 0.0 1.4 1 0 0 1 1 1 1 Carbamoyltransferase C-terminus Carbam_trans_N PF02543.15 CDL01404.1 - 8.2e-32 111.2 0.0 1.4e-31 110.4 0.0 1.3 1 1 0 1 1 1 1 Carbamoyltransferase N-terminus Peptidase_M22 PF00814.25 CDL01404.1 - 0.037 13.7 0.0 0.23 11.1 0.0 2.0 2 0 0 2 2 2 0 Glycoprotease family CTP_transf_3 PF02348.19 CDL01405.1 - 6.2e-18 65.5 0.0 8e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 CDL01405.1 - 3e-07 30.9 1.1 3e-07 30.9 1.1 2.2 2 1 0 2 2 2 1 MobA-like NTP transferase domain DUF2064 PF09837.9 CDL01405.1 - 0.0008 19.2 0.1 0.0033 17.2 0.1 2.1 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2064) EccE PF11203.8 CDL01406.1 - 0.41 11.0 3.9 0.17 12.2 0.8 2.0 2 1 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE NeuB PF03102.14 CDL01407.1 - 9.3e-64 215.2 0.0 1.1e-63 214.9 0.0 1.1 1 0 0 1 1 1 1 NeuB family DAHP_synth_1 PF00793.20 CDL01407.1 - 0.051 12.4 0.0 0.094 11.6 0.0 1.4 1 0 0 1 1 1 0 DAHP synthetase I family DUF4031 PF13223.6 CDL01407.1 - 0.056 13.7 0.1 11 6.4 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4031) DegT_DnrJ_EryC1 PF01041.17 CDL01408.1 - 3.4e-98 329.3 0.0 3.8e-98 329.1 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CDL01408.1 - 0.00028 20.2 0.0 0.00044 19.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CDL01408.1 - 0.0086 15.4 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 CDL01408.1 - 0.01 14.4 0.0 0.018 13.6 0.0 1.4 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Radical_SAM PF04055.21 CDL01409.1 - 1.6e-12 48.1 0.0 2.6e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily SPASM PF13186.6 CDL01409.1 - 0.0013 19.2 0.2 0.004 17.6 0.2 1.9 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Fer4_12 PF13353.6 CDL01409.1 - 0.002 18.4 0.0 0.0034 17.6 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CDL01409.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain WbqC PF08889.11 CDL01410.1 - 1.9e-70 237.2 0.0 2.1e-70 237.0 0.0 1.0 1 0 0 1 1 1 1 WbqC-like protein family Methyltransf_23 PF13489.6 CDL01411.1 - 9e-10 38.6 0.0 2.4e-09 37.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDL01411.1 - 2.8e-05 24.8 0.7 0.00023 21.8 0.7 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CDL01411.1 - 0.00025 20.1 0.0 0.00032 19.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_11 PF08241.12 CDL01411.1 - 0.00026 21.6 0.5 0.0012 19.4 0.5 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDL01411.1 - 0.0013 19.4 0.4 0.0075 17.0 0.4 2.1 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDL01411.1 - 0.0082 15.5 0.1 0.026 13.8 0.1 1.7 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.6 CDL01411.1 - 0.063 13.1 0.1 0.32 10.8 0.1 1.9 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.19 CDL01411.1 - 0.11 12.6 0.1 0.15 12.1 0.1 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 CDL01411.1 - 0.18 11.1 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain MTS PF05175.14 CDL01411.1 - 0.25 10.9 0.1 0.39 10.2 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Glycos_transf_2 PF00535.26 CDL01412.1 - 2.7e-12 46.8 0.0 3.8e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 CDL01412.1 - 0.0073 16.8 0.1 0.023 15.2 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 CDL01412.1 - 0.043 13.3 0.0 0.065 12.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 NTP_transferase PF00483.23 CDL01413.1 - 6.2e-26 91.5 0.0 7.7e-26 91.2 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CDL01413.1 - 1e-11 45.4 0.8 1.2e-11 45.2 0.8 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glyco_transf_41 PF13844.6 CDL01414.1 - 3.9e-35 121.2 0.0 3.3e-18 65.4 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 41 TPR_16 PF13432.6 CDL01414.1 - 2e-34 118.0 43.2 2e-09 37.9 1.5 7.4 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 CDL01414.1 - 5e-33 110.6 9.1 0.00095 19.1 0.0 10.0 9 1 1 10 10 10 7 Tetratricopeptide repeat TPR_1 PF00515.28 CDL01414.1 - 4.6e-32 108.5 0.2 0.00074 19.2 0.0 9.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 CDL01414.1 - 1.4e-29 99.8 0.0 0.0013 18.8 0.0 8.5 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 CDL01414.1 - 6.5e-27 91.9 0.2 0.00063 19.9 0.0 9.6 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDL01414.1 - 1.9e-25 88.2 0.0 2.5e-05 23.9 0.0 7.1 4 3 2 7 7 7 5 TPR repeat TPR_19 PF14559.6 CDL01414.1 - 5.1e-24 84.6 15.3 4.4e-08 33.5 0.1 6.6 3 2 2 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.6 CDL01414.1 - 5e-22 76.7 50.0 0.00022 21.8 0.4 11.0 3 1 9 12 12 11 8 Tetratricopeptide repeat TPR_7 PF13176.6 CDL01414.1 - 1.1e-21 75.1 15.6 0.0099 15.8 0.0 9.7 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 CDL01414.1 - 2.4e-16 59.8 26.0 2.2e-06 27.8 0.0 8.0 3 1 6 9 9 9 4 Tetratricopeptide repeat TPR_9 PF13371.6 CDL01414.1 - 3e-14 52.9 33.2 7.4e-07 29.2 0.8 6.9 3 1 2 6 6 6 4 Tetratricopeptide repeat TPR_15 PF13429.6 CDL01414.1 - 1e-12 47.9 5.4 0.00066 19.0 0.1 4.8 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_4 PF07721.14 CDL01414.1 - 1.9e-10 40.3 40.2 0.04 14.5 0.2 10.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_10 PF13374.6 CDL01414.1 - 4.3e-10 39.1 37.0 0.12 12.3 0.2 10.2 10 0 0 10 10 10 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CDL01414.1 - 8.7e-09 35.5 0.0 0.0006 20.0 0.0 4.9 4 1 2 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 CDL01414.1 - 1.4e-07 31.7 4.2 0.5 10.7 0.1 5.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDL01414.1 - 1.1e-05 25.8 14.2 9.3 7.1 0.0 8.2 9 0 0 9 9 8 0 Tetratricopeptide repeat PknG_TPR PF16918.5 CDL01414.1 - 0.0032 16.2 0.5 0.013 14.3 0.5 2.0 1 1 0 1 1 1 1 Protein kinase G tetratricopeptide repeat NARP1 PF12569.8 CDL01414.1 - 0.016 14.1 0.0 0.22 10.4 0.0 2.5 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 TPR_MalT PF17874.1 CDL01414.1 - 0.021 14.2 8.8 0.8 9.0 2.3 4.0 1 1 3 4 4 4 0 MalT-like TPR region HrpB1_HrpK PF09613.10 CDL01414.1 - 2 8.1 5.9 8.5 6.0 0.5 3.5 2 1 2 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) SPASM PF13186.6 CDL01415.1 - 4.2e-12 46.4 0.9 9.4e-12 45.3 0.9 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Radical_SAM PF04055.21 CDL01415.1 - 1.5e-11 44.9 0.1 3.2e-11 43.9 0.1 1.6 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CDL01415.1 - 0.053 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain Epimerase PF01370.21 CDL01416.1 - 2.4e-47 161.4 0.0 3.1e-47 161.1 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDL01416.1 - 1.4e-35 123.3 0.0 2.1e-35 122.7 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CDL01416.1 - 4.8e-10 38.9 0.0 6.3e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CDL01416.1 - 1.8e-06 27.3 0.0 2.7e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CDL01416.1 - 2.3e-06 27.0 0.0 7.8e-05 21.9 0.0 2.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CDL01416.1 - 0.0052 16.3 0.0 0.025 14.0 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CDL01416.1 - 0.015 15.2 0.0 0.097 12.6 0.0 2.0 2 0 0 2 2 2 0 KR domain ThiF PF00899.21 CDL01416.1 - 0.039 13.3 0.1 0.064 12.6 0.1 1.3 1 0 0 1 1 1 0 ThiF family UDPG_MGDP_dh_N PF03721.14 CDL01416.1 - 0.19 11.3 0.1 0.28 10.7 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Hydrolase_like PF13242.6 CDL01417.1 - 0.0068 16.4 0.1 0.015 15.3 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like 5_nucleotid PF05761.14 CDL01417.1 - 0.016 14.2 0.0 0.067 12.1 0.0 1.8 2 0 0 2 2 2 0 5' nucleotidase family HAD_2 PF13419.6 CDL01417.1 - 0.073 13.1 0.0 0.099 12.7 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DegT_DnrJ_EryC1 PF01041.17 CDL01420.1 - 7.2e-45 153.8 0.0 8.5e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family NTP_transferase PF00483.23 CDL01421.1 - 3.5e-50 170.9 0.0 4e-50 170.7 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CDL01421.1 - 6.5e-09 36.3 0.2 8.5e-09 36.0 0.2 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 CDL01421.1 - 0.067 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase adh_short_C2 PF13561.6 CDL01422.1 - 5.7e-57 193.0 8.7 1.1e-56 192.0 8.7 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDL01422.1 - 1.8e-46 158.0 8.0 7.7e-46 156.0 8.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDL01422.1 - 3.7e-11 43.3 4.5 3.3e-09 36.9 0.0 2.2 1 1 1 2 2 2 2 KR domain Hexapep PF00132.24 CDL01423.1 - 1.3e-13 50.0 6.2 9.1e-07 28.4 2.1 3.4 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) PglD_N PF17836.1 CDL01423.1 - 1.1e-06 29.2 0.0 1.7e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 PglD N-terminal domain Hexapep_2 PF14602.6 CDL01423.1 - 0.00044 19.9 5.9 0.46 10.3 0.9 3.7 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase TPR_11 PF13414.6 CDL01424.1 - 3.9e-37 125.7 8.0 1.6e-12 46.9 0.4 7.4 3 2 4 7 7 7 5 TPR repeat TPR_1 PF00515.28 CDL01424.1 - 3.4e-36 121.6 1.7 0.00011 21.9 0.3 7.8 8 0 0 8 8 7 7 Tetratricopeptide repeat TPR_2 PF07719.17 CDL01424.1 - 7.5e-34 113.1 9.8 2.1e-05 24.3 0.9 9.1 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 CDL01424.1 - 2.6e-29 98.9 0.0 0.00087 19.3 0.1 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDL01424.1 - 7.6e-27 93.7 24.0 2.4e-10 40.9 6.5 5.6 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_17 PF13431.6 CDL01424.1 - 1.8e-25 87.4 13.6 1.6e-05 24.9 0.2 7.9 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 CDL01424.1 - 6.3e-20 70.2 24.6 0.0001 22.8 1.0 8.4 3 3 5 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 CDL01424.1 - 6.1e-19 68.1 18.4 5.1e-05 23.5 2.9 6.6 2 2 5 7 7 7 7 Tetratricopeptide repeat TPR_19 PF14559.6 CDL01424.1 - 1.2e-16 60.9 17.0 9.7e-09 35.6 3.6 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 CDL01424.1 - 2.4e-16 59.0 29.9 0.0044 16.8 0.3 7.8 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_7 PF13176.6 CDL01424.1 - 9.9e-16 56.5 9.0 0.13 12.4 0.3 7.7 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_4 PF07721.14 CDL01424.1 - 1.3e-11 43.9 21.6 0.089 13.5 0.3 9.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_15 PF13429.6 CDL01424.1 - 1.2e-06 28.0 3.7 0.06 12.5 0.8 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat Glyco_transf_9 PF01075.17 CDL01424.1 - 1.1e-05 24.9 0.4 2.1e-05 24.0 0.4 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 9 (heptosyltransferase) TPR_6 PF13174.6 CDL01424.1 - 7.4e-05 23.1 15.5 3 8.7 0.2 7.7 8 1 1 9 9 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDL01424.1 - 0.0002 21.4 18.6 0.61 10.3 0.6 5.4 2 2 2 5 5 5 2 Tetratricopeptide repeat BTAD PF03704.17 CDL01424.1 - 0.0015 18.9 10.9 0.013 15.9 0.3 4.1 2 1 0 3 3 3 1 Bacterial transcriptional activator domain TPR_MalT PF17874.1 CDL01424.1 - 0.0026 17.2 2.2 0.78 9.0 0.6 2.7 1 1 1 2 2 2 2 MalT-like TPR region Fis1_TPR_C PF14853.6 CDL01424.1 - 0.0076 16.3 0.4 0.067 13.3 0.0 2.7 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 CDL01424.1 - 0.011 15.8 4.0 1.2 9.3 0.1 4.3 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 CDL01424.1 - 0.022 14.8 0.5 17 5.5 0.1 5.0 3 1 2 5 5 5 0 Domain of Unknown Function (DUF3856) TPR_5 PF12688.7 CDL01424.1 - 0.042 14.1 5.1 4.6 7.5 0.4 4.2 3 1 0 3 3 3 0 Tetratrico peptide repeat ANAPC3 PF12895.7 CDL01424.1 - 0.2 11.9 3.2 45 4.4 0.0 3.7 1 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 CDL01424.1 - 0.25 11.0 11.6 1 9.0 0.1 4.3 2 2 1 3 3 3 0 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 CDL01424.1 - 1.3 9.4 13.7 12 6.3 0.3 5.2 3 2 1 5 5 5 0 Tetratricopeptide repeat PP-binding PF00550.25 CDL01425.1 - 2.6e-05 24.5 0.4 4.6e-05 23.7 0.4 1.4 1 1 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CDL01425.1 - 0.05 13.8 0.0 0.054 13.7 0.0 1.1 1 0 0 1 1 1 0 Acyl-carrier AMP-binding PF00501.28 CDL01426.1 - 1.5e-43 149.0 0.0 4.9e-42 144.0 0.0 2.0 1 1 0 1 1 1 1 AMP-binding enzyme Hexapep PF00132.24 CDL01427.1 - 1.1e-09 37.7 11.3 6.1e-08 32.1 3.1 3.2 4 0 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDL01427.1 - 0.0042 16.8 6.9 0.0072 16.1 2.7 2.6 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Flagellin_N PF00669.20 CDL01428.1 - 3.5e-13 49.9 14.7 3.5e-13 49.9 14.7 3.1 1 1 3 4 4 4 1 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 CDL01428.1 - 6.6e-08 32.8 2.6 6.6e-08 32.8 2.6 3.9 2 1 1 4 4 4 1 Bacterial flagellin C-terminal helical region ATP-synt_D PF01813.17 CDL01428.1 - 0.00026 20.9 0.9 0.00049 20.0 0.9 1.4 1 0 0 1 1 1 1 ATP synthase subunit D FolB PF02152.18 CDL01428.1 - 0.011 16.3 0.2 0.03 14.9 0.1 1.8 2 0 0 2 2 2 0 Dihydroneopterin aldolase MG1 PF17790.1 CDL01428.1 - 0.018 15.4 2.0 0.04 14.3 2.0 1.5 1 0 0 1 1 1 0 Macroglobulin domain MG1 Fucose_iso_N1 PF07881.12 CDL01428.1 - 0.049 13.5 0.8 0.082 12.8 0.1 1.8 2 0 0 2 2 2 0 L-fucose isomerase, first N-terminal domain DUF724 PF05266.14 CDL01428.1 - 0.077 12.8 1.7 0.24 11.2 1.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF743 PF05332.11 CDL01428.1 - 0.18 11.8 3.3 0.5 10.4 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF743) LAMTOR5 PF16672.5 CDL01428.1 - 0.26 11.3 1.9 0.83 9.6 0.8 2.5 2 1 1 3 3 3 0 Ragulator complex protein LAMTOR5 Syntaxin-6_N PF09177.11 CDL01428.1 - 0.39 11.3 4.1 37 5.0 0.0 3.0 2 1 1 3 3 3 0 Syntaxin 6, N-terminal YtxH PF12732.7 CDL01428.1 - 3.1 8.4 9.4 0.98 10.0 0.3 3.3 4 0 0 4 4 4 0 YtxH-like protein Acetyltransf_6 PF13480.7 CDL01429.1 - 0.0035 17.5 3.3 0.0035 17.5 3.3 2.9 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain FlaF PF07309.11 CDL01430.1 - 8.3e-28 96.7 0.0 9.9e-28 96.4 0.0 1.1 1 0 0 1 1 1 1 Flagellar protein FlaF Glyco_transf_41 PF13844.6 CDL01431.1 - 5.3e-09 35.0 0.0 0.00044 18.8 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 41 ANAPC3 PF12895.7 CDL01431.1 - 2.7e-06 27.5 0.4 0.16 12.2 0.0 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 CDL01431.1 - 0.00038 20.9 8.9 0.49 10.9 0.0 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDL01431.1 - 0.00075 19.2 0.1 2.8 7.9 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDL01431.1 - 0.00077 19.7 9.8 0.17 12.2 0.0 4.7 3 2 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDL01431.1 - 0.036 14.9 22.1 6.7 7.8 0.6 6.2 3 2 3 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDL01431.1 - 6.2 7.1 13.4 5.6 7.2 1.4 3.9 5 1 0 5 5 5 0 Tetratricopeptide repeat MAF_flag10 PF01973.18 CDL01432.1 - 7.3e-44 149.5 0.0 1.3e-43 148.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF115 PP-binding PF00550.25 CDL01433.1 - 0.0015 18.8 0.0 0.0045 17.3 0.0 1.7 2 0 0 2 2 2 1 Phosphopantetheine attachment site Antibiotic_NAT PF02522.14 CDL01434.1 - 3.9e-27 95.5 0.0 5.4e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 Aminoglycoside 3-N-acetyltransferase DUF4910 PF16254.5 CDL01434.1 - 4.7e-10 38.8 0.0 6.6e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4910) DUF2172 PF09940.9 CDL01434.1 - 0.0009 19.6 0.0 0.0016 18.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2172) AMP-binding PF00501.28 CDL01435.1 - 8.6e-84 281.6 0.0 1e-83 281.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDL01435.1 - 2.9e-11 44.2 0.7 7.9e-11 42.8 0.0 2.2 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain Radical_SAM PF04055.21 CDL01436.1 - 8.5e-10 39.2 0.0 3e-09 37.5 0.0 2.0 1 1 0 1 1 1 1 Radical SAM superfamily Glycos_transf_2 PF00535.26 CDL01437.1 - 2.2e-29 102.5 0.0 3.2e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDL01437.1 - 5.8e-18 65.6 0.2 7.4e-18 65.3 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CDL01437.1 - 1.2e-13 51.2 0.0 1.8e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 CDL01437.1 - 4.2e-05 24.0 0.0 0.00046 20.7 0.0 2.4 1 1 1 2 2 2 1 Glycosyl transferase family 2 GFO_IDH_MocA PF01408.22 CDL01438.1 - 1.2e-15 58.4 0.0 1.8e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Peptidase_C39_2 PF13529.6 CDL01438.1 - 0.048 14.2 0.0 0.33 11.5 0.0 2.0 2 0 0 2 2 2 0 Peptidase_C39 like family ddrB-ParB PF18763.1 CDL01438.1 - 0.073 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 ddrB-like ParB superfamily domain DUF4910 PF16254.5 CDL01439.1 - 1.5e-109 364.6 0.0 1.8e-109 364.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4910) DUF2172 PF09940.9 CDL01439.1 - 3.7e-38 129.8 0.0 7.2e-38 128.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF2172) HTH_47 PF16221.5 CDL01439.1 - 1.5e-25 88.6 0.1 2.6e-25 87.8 0.1 1.4 1 0 0 1 1 1 1 winged helix-turn-helix MarR_2 PF12802.7 CDL01439.1 - 0.022 14.6 0.3 6.7 6.7 0.0 2.8 2 0 0 2 2 2 0 MarR family DoxX_2 PF13564.6 CDL01439.1 - 0.051 13.7 0.5 0.15 12.2 0.1 1.9 2 0 0 2 2 2 0 DoxX-like family Peptidase_M28 PF04389.17 CDL01439.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M28 tRNA-synt_2e PF02091.15 CDL01440.1 - 1e-151 503.9 0.0 1.2e-151 503.7 0.0 1.0 1 0 0 1 1 1 1 Glycyl-tRNA synthetase alpha subunit N-glycanase_C PF09113.10 CDL01440.1 - 0.002 17.9 0.1 0.0033 17.2 0.1 1.3 1 0 0 1 1 1 1 Peptide-N-glycosidase F, C terminal Lipase_C PF18067.1 CDL01440.1 - 0.17 12.5 0.0 0.44 11.1 0.0 1.6 1 0 0 1 1 1 0 Lipase C-terminal domain DUF1937 PF09152.10 CDL01440.1 - 0.17 12.7 0.0 0.3 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1937) tRNA_synt_2f PF02092.17 CDL01441.1 - 2e-204 680.4 0.0 2.5e-204 680.1 0.0 1.1 1 0 0 1 1 1 1 Glycyl-tRNA synthetase beta subunit DALR_1 PF05746.15 CDL01441.1 - 3.2e-09 37.0 0.4 1.3e-08 35.0 0.2 2.1 2 0 0 2 2 2 1 DALR anticodon binding domain Trp_DMAT PF11991.8 CDL01441.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Tryptophan dimethylallyltransferase PEP-utilizers_C PF02896.18 CDL01442.1 - 1.1e-96 323.4 0.0 4.6e-96 321.4 0.0 1.9 2 0 0 2 2 2 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.19 CDL01442.1 - 3.9e-69 233.4 0.0 2e-65 221.2 0.0 3.2 1 1 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.23 CDL01442.1 - 3.5e-27 93.9 2.7 1.2e-26 92.2 2.7 2.0 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain HalOD1 PF18545.1 CDL01442.1 - 0.0039 17.4 0.0 0.015 15.5 0.0 2.0 1 0 0 1 1 1 1 Halobacterial output domain 1 HigB-like_toxin PF05015.13 CDL01443.1 - 2.4e-16 59.9 0.0 2.7e-16 59.8 0.0 1.0 1 0 0 1 1 1 1 RelE-like toxin of type II toxin-antitoxin system HigB YafQ_toxin PF15738.5 CDL01443.1 - 0.00059 20.1 0.0 0.00067 19.9 0.0 1.1 1 0 0 1 1 1 1 Bacterial toxin of type II toxin-antitoxin system, YafQ HTH_3 PF01381.22 CDL01444.1 - 8.5e-09 35.4 0.0 1.5e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CDL01444.1 - 0.00053 20.3 0.0 0.0007 19.9 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 CDL01444.1 - 0.00074 19.9 0.0 0.001 19.5 0.0 1.2 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_19 PF12844.7 CDL01444.1 - 0.0059 16.6 0.0 0.0088 16.1 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain YdaS_antitoxin PF15943.5 CDL01444.1 - 0.0084 16.0 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_35 PF13693.6 CDL01444.1 - 0.013 15.5 0.0 0.02 14.9 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TonB_2 PF13103.6 CDL01445.1 - 0.077 13.2 3.8 8.5 6.7 0.0 3.0 3 1 1 4 4 4 0 TonB C terminal Response_reg PF00072.24 CDL01446.1 - 2.6e-19 69.4 0.0 3.3e-19 69.1 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Hemerythrin PF01814.23 CDL01447.1 - 1.9e-06 28.6 3.2 2.4e-06 28.2 3.2 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF1127 PF06568.11 CDL01448.1 - 2.2e-11 43.2 6.0 3.2e-11 42.8 6.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1127) CcmD PF04995.14 CDL01448.1 - 0.054 13.6 1.2 0.11 12.7 1.2 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) GntR PF00392.21 CDL01449.1 - 5.1e-11 42.1 0.1 5.1e-11 42.1 0.1 2.0 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family Aminotran_1_2 PF00155.21 CDL01449.1 - 2.2e-10 40.3 0.0 2.9e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II HTH_Crp_2 PF13545.6 CDL01449.1 - 0.003 17.5 0.0 0.0074 16.2 0.0 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Cys_Met_Meta_PP PF01053.20 CDL01449.1 - 0.019 13.5 0.0 0.025 13.1 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Chromate_transp PF02417.15 CDL01450.1 - 1.5e-67 226.6 37.3 2.1e-36 125.4 11.3 2.2 2 0 0 2 2 2 2 Chromate transporter MFS_1_like PF12832.7 CDL01451.1 - 1.5e-57 195.3 13.6 2.8e-57 194.3 13.6 1.4 1 1 0 1 1 1 1 MFS_1 like family LacY_symp PF01306.19 CDL01451.1 - 3e-21 75.7 5.8 1.1e-20 73.8 5.8 1.7 1 1 0 1 1 1 1 LacY proton/sugar symporter MFS_1 PF07690.16 CDL01451.1 - 2e-15 56.6 53.7 7.4e-14 51.4 30.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.16 CDL01451.1 - 1.7e-14 53.6 13.8 2.1e-14 53.4 13.8 1.0 1 0 0 1 1 1 1 Nucleoside H+ symporter Ecm33 PF12454.8 CDL01451.1 - 0.12 12.6 0.4 0.43 10.8 0.4 2.0 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein YdjC PF04794.12 CDL01452.1 - 7.4e-48 163.6 0.0 8.4e-48 163.4 0.0 1.0 1 0 0 1 1 1 1 YdjC-like protein CMD PF02627.20 CDL01452.1 - 0.046 13.8 1.1 0.093 12.8 0.1 1.9 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family Glycos_transf_2 PF00535.26 CDL01453.1 - 7.5e-31 107.2 0.1 9.7e-31 106.9 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDL01453.1 - 1.4e-10 41.5 0.2 1.7e-10 41.2 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CDL01453.1 - 7.2e-06 25.6 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 CDL01453.1 - 0.016 14.7 0.0 0.075 12.5 0.0 1.8 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Rrf2 PF02082.20 CDL01454.1 - 2e-25 88.9 0.1 3.1e-25 88.3 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator Hint_2 PF13403.6 CDL01454.1 - 0.17 12.2 0.0 0.93 9.8 0.0 2.0 2 1 0 2 2 2 0 Hint domain Virul_fac_BrkB PF03631.15 CDL01455.1 - 4.8e-55 187.0 30.4 6.6e-55 186.5 30.4 1.2 1 0 0 1 1 1 1 Virulence factor BrkB C166 PF17615.2 CDL01455.1 - 0.0023 18.1 2.1 0.0023 18.1 2.1 2.2 2 0 0 2 2 2 1 Family of unknown function adh_short_C2 PF13561.6 CDL01456.1 - 9e-87 290.5 0.0 1e-86 290.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDL01456.1 - 9.9e-20 70.8 0.0 1.3e-19 70.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDL01456.1 - 0.0031 17.4 0.0 0.0068 16.3 0.0 1.6 2 0 0 2 2 2 1 KR domain Chorismate_synt PF01264.21 CDL01457.1 - 9.1e-137 455.1 0.0 1e-136 455.0 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase dCache_1 PF02743.18 CDL01458.1 - 2.8e-22 79.7 0.0 2.3e-18 66.9 0.0 2.3 2 0 0 2 2 2 2 Cache domain HATPase_c PF02518.26 CDL01458.1 - 6.7e-12 45.9 0.0 1.7e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CDL01458.1 - 2e-05 24.5 0.0 6.6e-05 22.9 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain Flagellin_N PF00669.20 CDL01460.1 - 5.5e-11 42.7 14.9 5.5e-11 42.7 14.9 2.4 2 1 0 2 2 2 1 Bacterial flagellin N-terminal helical region Flagellin_C PF00700.21 CDL01460.1 - 0.0072 16.7 5.3 0.0072 16.7 5.3 3.1 3 1 0 3 3 3 1 Bacterial flagellin C-terminal helical region FlaF PF07309.11 CDL01461.1 - 2.3e-27 95.2 0.1 2.6e-27 95.1 0.1 1.0 1 0 0 1 1 1 1 Flagellar protein FlaF Fibrinogen_BP PF08017.11 CDL01461.1 - 0.01 14.3 0.1 0.012 14.1 0.1 1.0 1 0 0 1 1 1 0 Fibrinogen binding protein Rhodanese PF00581.20 CDL01462.1 - 8.9e-12 45.5 0.0 1.5e-11 44.8 0.0 1.4 1 1 0 1 1 1 1 Rhodanese-like domain DUF1697 PF08002.11 CDL01462.1 - 0.13 12.8 0.0 0.16 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1697) Peptidase_S49 PF01343.18 CDL01463.1 - 6.8e-70 234.0 0.0 1.7e-43 148.3 0.0 2.2 2 0 0 2 2 2 2 Peptidase family S49 CLP_protease PF00574.23 CDL01463.1 - 0.00022 21.2 0.1 0.0054 16.6 0.2 2.7 3 0 0 3 3 3 1 Clp protease ECH_1 PF00378.20 CDL01463.1 - 0.019 14.3 4.2 0.05 12.9 0.4 3.1 4 0 0 4 4 4 0 Enoyl-CoA hydratase/isomerase SDH_sah PF01972.16 CDL01463.1 - 0.048 12.6 0.4 0.084 11.9 0.4 1.3 1 0 0 1 1 1 0 Serine dehydrogenase proteinase Herpes_ICP4_N PF03584.15 CDL01463.1 - 0.094 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus ICP4-like protein N-terminal region MdcE PF06833.11 CDL01463.1 - 0.095 12.2 3.0 0.35 10.3 3.0 1.9 1 1 0 1 1 1 0 Malonate decarboxylase gamma subunit (MdcE) adh_short_C2 PF13561.6 CDL01464.1 - 8.9e-48 162.9 0.0 1e-47 162.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDL01464.1 - 1.7e-47 161.4 0.0 2.1e-47 161.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDL01464.1 - 9.9e-05 22.3 0.0 0.00025 21.0 0.0 1.8 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CDL01464.1 - 0.00019 21.0 0.0 0.00043 19.8 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Glyco_trans_4_4 PF13579.6 CDL01464.1 - 0.0032 17.9 1.7 1.1 9.7 0.1 2.4 3 0 0 3 3 3 2 Glycosyl transferase 4-like domain RmlD_sub_bind PF04321.17 CDL01464.1 - 0.19 10.8 0.0 0.3 10.1 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain LysR_substrate PF03466.20 CDL01465.1 - 1.1e-49 168.6 5.9 1.5e-49 168.2 5.9 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDL01465.1 - 6.6e-17 61.2 2.1 6.6e-17 61.2 2.1 1.9 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family Ferritin PF00210.24 CDL01466.1 - 7.7e-28 97.2 0.0 8.8e-28 97.0 0.0 1.0 1 0 0 1 1 1 1 Ferritin-like domain TFCD_C PF12612.8 CDL01466.1 - 0.15 11.9 0.0 0.51 10.1 0.0 1.8 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal Cu_amine_oxidN2 PF02727.16 CDL01467.1 - 0.07 13.4 0.0 20 5.5 0.0 2.5 2 0 0 2 2 2 0 Copper amine oxidase, N2 domain SpoIIE PF07228.12 CDL01468.1 - 4.4e-29 101.8 0.3 8.3e-29 100.9 0.3 1.5 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Response_reg PF00072.24 CDL01468.1 - 4.7e-26 91.1 0.0 8.3e-26 90.4 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c_2 PF13581.6 CDL01468.1 - 3.9e-12 46.2 0.0 1.2e-11 44.6 0.0 1.9 1 1 0 1 1 1 1 Histidine kinase-like ATPase domain DUF3370 PF11850.8 CDL01468.1 - 0.15 10.9 0.0 0.27 10.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3370) STAS_2 PF13466.6 CDL01469.1 - 3.5e-13 49.7 2.7 4.3e-13 49.4 2.7 1.0 1 0 0 1 1 1 1 STAS domain STAS PF01740.21 CDL01469.1 - 2.5e-11 43.3 0.0 2.8e-11 43.1 0.0 1.0 1 0 0 1 1 1 1 STAS domain BenE PF03594.13 CDL01469.1 - 0.047 12.5 0.0 0.055 12.2 0.0 1.0 1 0 0 1 1 1 0 Benzoate membrane transport protein MCPsignal PF00015.21 CDL01470.1 - 3e-29 102.0 40.8 6.5e-29 100.9 25.2 3.6 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 CDL01470.1 - 1.2e-09 38.4 3.7 1.5e-09 38.1 0.4 3.1 2 0 0 2 2 2 1 HAMP domain 4HB_MCP_1 PF12729.7 CDL01470.1 - 0.0012 18.4 0.2 0.0012 18.4 0.2 3.3 2 1 1 3 3 3 1 Four helix bundle sensory module for signal transduction CorA PF01544.18 CDL01470.1 - 0.055 12.8 6.1 0.69 9.2 0.2 3.7 3 1 1 4 4 4 0 CorA-like Mg2+ transporter protein DUF1664 PF07889.12 CDL01470.1 - 0.07 13.2 9.1 7.4 6.6 1.9 4.4 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 CDL01470.1 - 4.4 7.6 23.0 2.8 8.2 0.5 5.3 3 1 3 6 6 6 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.22 CDL01470.1 - 6.5 7.0 8.7 84 3.5 0.0 4.1 2 2 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain SoxY PF13501.6 CDL01471.1 - 3.8e-33 114.1 0.2 5.2e-33 113.6 0.2 1.2 1 0 0 1 1 1 1 Sulfur oxidation protein SoxY HRDC PF00570.23 CDL01471.1 - 0.048 13.6 0.0 0.087 12.8 0.0 1.4 1 0 0 1 1 1 0 HRDC domain SoxZ PF08770.11 CDL01472.1 - 1.1e-26 92.5 0.0 1.1e-26 92.4 0.0 1.0 1 0 0 1 1 1 1 Sulphur oxidation protein SoxZ Semialdhyde_dhC PF02774.18 CDL01473.1 - 2.3e-57 194.0 0.0 3.4e-57 193.5 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 CDL01473.1 - 8.5e-32 110.1 0.1 1.5e-31 109.3 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CDL01473.1 - 0.0011 19.1 0.3 0.0041 17.2 0.0 2.1 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.13 CDL01473.1 - 0.013 15.1 0.1 0.025 14.1 0.1 1.5 1 0 0 1 1 1 0 NmrA-like family RAP-1 PF03085.15 CDL01473.1 - 0.021 14.6 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Gp_dh_C PF02800.20 CDL01473.1 - 0.021 14.4 2.1 0.059 13.0 0.2 2.1 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain NAD_binding_10 PF13460.6 CDL01473.1 - 0.031 14.2 0.2 0.071 13.0 0.0 1.8 2 0 0 2 2 2 0 NAD(P)H-binding Ldh_1_N PF00056.23 CDL01473.1 - 0.037 14.1 0.0 0.088 12.9 0.0 1.7 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CDL01473.1 - 0.053 14.1 0.1 0.12 13.0 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Nuc_rec_co-act PF08815.10 CDL01474.1 - 0.028 14.2 0.2 0.074 12.9 0.0 1.8 2 0 0 2 2 2 0 Nuclear receptor coactivator DUF896 PF05979.12 CDL01474.1 - 0.2 11.5 0.8 0.35 10.8 0.8 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) TPR_2 PF07719.17 CDL01475.1 - 0.0012 18.8 1.0 0.0012 18.8 1.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDL01475.1 - 0.0032 17.7 3.9 0.012 15.9 0.4 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDL01475.1 - 0.0054 16.9 0.3 0.012 15.7 0.3 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_4 PF07721.14 CDL01475.1 - 0.022 15.4 2.4 0.16 12.7 2.4 2.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDL01475.1 - 0.028 14.9 2.8 0.22 12.0 0.2 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDL01475.1 - 0.031 14.9 0.8 0.031 14.9 0.8 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDL01475.1 - 3.6 8.6 7.3 0.66 10.9 1.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat Ribosomal_S20p PF01649.18 CDL01476.1 - 2e-26 92.4 7.5 2.2e-26 92.3 7.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S20 DUF2786 PF10979.8 CDL01476.1 - 0.0044 16.9 4.2 0.042 13.8 2.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2786) # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Magnetospirillum_gryphiswaldense_MSR-1_v2-MGMSRv2/GCA_000513295.1_MGMSRv2_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Magnetospirillum_gryphiswaldense_MSR-1_v2-MGMSRv2/GCA_000513295.1_MGMSRv2_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Magnetospirillum_gryphiswaldense_MSR-1_v2-MGMSRv2/GCA_000513295.1_MGMSRv2_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Bacteria/Magnetospirillum_gryphiswaldense_MSR-1_v2-MGMSRv2/GCA_000513295.1_MGMSRv2_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 03:01:37 2019 # [ok]