# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Copine PF07002.16 EKE36869.1 - 1.4e-55 188.1 0.0 1.7e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EKE36869.1 - 1.5e-11 44.8 0.0 2.1e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EKE36869.1 - 0.0077 16.5 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain HypD PF01924.16 EKE36869.1 - 0.053 12.6 0.1 0.078 12.0 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase formation hypA family VPS9 PF02204.18 EKE36870.1 - 6.7e-11 42.3 0.8 6.7e-11 42.3 0.8 1.7 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain DUF4830 PF16112.5 EKE36870.1 - 0.053 14.0 0.2 0.15 12.5 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4830) ThiJ_like PF17124.5 EKE36870.1 - 0.11 12.2 0.4 0.48 10.1 0.0 2.0 2 0 0 2 2 2 0 ThiJ/PfpI family-like CTP_transf_1 PF01148.20 EKE36871.1 - 0.00048 20.0 12.5 0.00069 19.5 12.5 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family DUF5056 PF16479.5 EKE36871.1 - 0.047 13.9 0.9 0.16 12.2 0.0 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5056) DUF202 PF02656.15 EKE36871.1 - 0.14 12.7 1.7 0.8 10.2 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Med14 PF08638.11 EKE36873.1 - 5.1e-06 26.0 0.1 1.1e-05 25.0 0.1 1.6 1 1 0 1 1 1 1 Mediator complex subunit MED14 RPW8 PF05659.11 EKE36873.1 - 8.6 6.0 8.9 6.5 6.4 0.1 3.1 2 2 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ANAPC4_WD40 PF12894.7 EKE36874.1 - 4.2e-06 27.0 0.0 1.5e-05 25.2 0.0 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EKE36874.1 - 3.4e-05 24.5 0.2 0.065 14.1 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat eIF2A PF08662.11 EKE36874.1 - 0.039 13.8 0.0 0.085 12.7 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Rap_GAP PF02145.15 EKE36875.1 - 0.0048 16.5 0.1 0.026 14.1 0.1 2.2 1 1 0 1 1 1 1 Rap/ran-GAP Metallophos PF00149.28 EKE36876.1 - 6.6e-09 36.6 1.1 1e-08 36.0 0.3 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pkinase PF00069.25 EKE36877.1 - 1.8e-62 211.1 5.5 2.9e-54 184.2 1.6 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EKE36877.1 - 5.7e-35 120.9 4.5 2.5e-31 108.9 0.5 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Trep_dent_lipo PF09710.10 EKE36877.1 - 4.6e-06 25.8 1.6 1.2e-05 24.5 1.6 1.7 1 0 0 1 1 1 1 Treponema clustered lipoprotein (Trep_dent_lipo) RIO1 PF01163.22 EKE36877.1 - 0.022 14.3 0.0 0.063 12.9 0.0 1.7 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EKE36877.1 - 0.032 13.0 0.0 0.058 12.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Sulfotransfer_3 PF13469.6 EKE36878.1 - 1e-21 78.3 0.0 1.7e-21 77.6 0.0 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EKE36878.1 - 3.4e-07 30.0 0.2 1.6e-06 27.8 0.2 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Spc7 PF08317.11 EKE36879.1 - 0.00079 18.4 15.8 0.00079 18.4 15.8 2.2 2 0 0 2 2 2 1 Spc7 kinetochore protein Caldesmon PF02029.15 EKE36879.1 - 0.55 8.9 51.8 0.81 8.4 51.8 1.1 1 0 0 1 1 1 0 Caldesmon Macoilin PF09726.9 EKE36879.1 - 2.2 6.7 37.6 3.1 6.3 37.6 1.1 1 0 0 1 1 1 0 Macoilin family OmpH PF03938.14 EKE36879.1 - 6.7 7.0 40.9 0.32 11.3 17.5 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) ATP12 PF07542.11 EKE36880.1 - 0.094 12.8 0.1 0.37 10.9 0.1 2.1 1 1 0 1 1 1 0 ATP12 chaperone protein DENN PF02141.21 EKE36881.1 - 1.5e-13 51.1 4.9 2.9e-13 50.2 4.9 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain Pkinase PF00069.25 EKE36883.1 - 1e-30 107.0 0.9 1.6e-30 106.3 0.9 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE36883.1 - 9.9e-29 100.4 0.2 1.8e-28 99.5 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase VSP PF03302.13 EKE36883.1 - 5.3e-05 22.2 66.5 0.00034 19.6 44.0 14.2 1 1 12 13 13 13 7 Giardia variant-specific surface protein Pkinase_fungal PF17667.1 EKE36883.1 - 0.0001 21.2 0.1 0.00016 20.6 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE36883.1 - 0.0021 17.4 0.0 0.0038 16.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Furin-like_2 PF15913.5 EKE36883.1 - 0.0061 16.7 9.5 0.0061 16.7 9.5 24.3 2 2 22 24 24 24 7 Furin-like repeat, cysteine-rich Pkinase_Tyr PF07714.17 EKE36884.1 - 6e-15 55.2 0.0 7.4e-15 54.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE36884.1 - 3.4e-12 46.3 0.0 4.1e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Myotub-related PF06602.14 EKE36885.1 - 5.6e-111 370.9 0.2 9.6e-111 370.1 0.2 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain TAP42 PF04177.12 EKE36885.1 - 0.012 14.8 1.4 0.021 14.0 0.9 1.6 1 1 1 2 2 2 0 TAP42-like family Y_phosphatase3 PF13350.6 EKE36885.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Herpes_UL56 PF04534.12 EKE36886.1 - 0.15 11.6 0.1 0.21 11.0 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL56 protein LRR_5 PF13306.6 EKE36887.1 - 4.2e-36 123.7 12.2 8.8e-24 83.9 4.8 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE36887.1 - 0.00072 19.3 0.0 1.6 8.5 0.0 3.4 2 1 1 3 3 3 3 Leucine rich repeat RhoGEF PF00621.20 EKE36888.1 - 2.1e-20 73.8 6.7 3.4e-20 73.0 6.7 1.4 1 0 0 1 1 1 1 RhoGEF domain TMEM144 PF07857.12 EKE36889.1 - 7.4e-84 281.6 11.4 1.6e-82 277.2 11.4 2.0 1 1 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 EKE36889.1 - 5.5e-10 39.0 12.9 3.2e-06 26.7 3.1 2.4 2 0 0 2 2 2 2 Sugar transport protein Ureide_permease PF07168.11 EKE36889.1 - 8.9e-09 34.6 3.9 0.0012 17.6 0.0 2.7 3 0 0 3 3 3 2 Ureide permease FAM176 PF14851.6 EKE36889.1 - 0.0049 16.5 0.9 0.011 15.4 0.9 1.6 1 0 0 1 1 1 1 FAM176 family V_ATPase_I PF01496.19 EKE36889.1 - 0.031 12.2 2.1 0.044 11.7 2.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2681 PF10883.8 EKE36889.1 - 0.047 14.1 0.2 0.12 12.8 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) MMM1 PF10296.9 EKE36889.1 - 0.1 11.6 1.4 0.15 11.1 1.4 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Ly49 PF08391.10 EKE36889.1 - 1.1 9.7 3.5 2.2 8.7 3.5 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Pox_Ag35 PF03286.14 EKE36889.1 - 1.4 8.7 8.9 2 8.2 8.9 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein MRNIP PF15749.5 EKE36890.1 - 2.8e-14 53.8 45.0 1.4e-08 35.4 45.0 3.5 1 1 0 1 1 1 1 MRN-interacting protein DNA_primase_S PF01896.19 EKE36891.1 - 2.6e-26 92.7 0.9 3.9e-26 92.2 0.9 1.2 1 0 0 1 1 1 1 DNA primase small subunit DpnII-MboI PF18742.1 EKE36891.1 - 0.00069 19.3 0.5 0.0015 18.2 0.5 1.6 1 0 0 1 1 1 1 REase_DpnII-MboI FMO-like PF00743.19 EKE36891.1 - 0.028 12.8 0.8 0.05 12.0 0.8 1.3 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like DNA_primase_S PF01896.19 EKE36892.1 - 1.1e-12 48.4 0.1 1.6e-12 47.8 0.1 1.3 1 0 0 1 1 1 1 DNA primase small subunit TLD PF07534.16 EKE36893.1 - 1.2e-06 28.7 3.6 1.7e-06 28.3 1.7 1.8 1 1 1 2 2 2 1 TLD SNAPc_SNAP43 PF09808.9 EKE36894.1 - 1.8e-17 63.9 3.6 3e-17 63.2 3.6 1.3 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 EF-hand_8 PF13833.6 EKE36894.1 - 0.096 12.5 0.1 0.24 11.3 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair Med3 PF11593.8 EKE36894.1 - 0.14 11.3 4.4 0.2 10.8 4.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Clathrin_propel PF01394.20 EKE36895.1 - 0.00019 21.6 0.8 0.029 14.7 0.2 3.1 2 0 0 2 2 2 1 Clathrin propeller repeat DUF4373 PF14297.6 EKE36895.1 - 0.014 16.1 1.3 0.062 14.1 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4373) Galactosyl_T PF01762.21 EKE36895.1 - 0.4 10.5 4.5 6.2 6.6 0.2 3.4 3 0 0 3 3 3 0 Galactosyltransferase G-patch PF01585.23 EKE36896.1 - 8.9e-08 31.9 1.7 1.9e-07 30.8 1.7 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EKE36896.1 - 0.061 13.4 0.9 0.061 13.4 0.9 2.2 2 0 0 2 2 2 0 G-patch domain MFS_2 PF13347.6 EKE36898.1 - 0.00039 19.1 23.7 0.0013 17.4 23.8 1.9 1 1 0 1 1 1 1 MFS/sugar transport protein DUF2371 PF10177.9 EKE36898.1 - 0.087 13.0 0.1 0.26 11.5 0.1 1.9 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) PGG PF13962.6 EKE36898.1 - 7.9 6.3 15.4 3.2 7.6 0.8 4.4 3 1 1 4 4 4 0 Domain of unknown function Peptidase_M24 PF00557.24 EKE36899.1 - 1.2e-51 175.4 0.0 1.6e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EKE36899.1 - 3.1e-21 75.4 0.0 9.4e-21 73.8 0.0 1.8 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain RRM_1 PF00076.22 EKE36900.1 - 2.9e-25 87.9 0.2 3.9e-25 87.5 0.2 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EKE36900.1 - 0.00051 20.1 0.0 0.0011 19.0 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.11 EKE36900.1 - 0.00067 19.7 0.2 0.001 19.1 0.2 1.4 1 0 0 1 1 1 1 RNA binding motif RRM_occluded PF16842.5 EKE36900.1 - 0.048 13.5 0.0 0.095 12.6 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.6 EKE36900.1 - 0.051 13.2 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 EKE36900.1 - 0.059 13.6 0.0 0.08 13.2 0.0 1.3 1 0 0 1 1 1 0 RRM-like domain Rap_GAP PF02145.15 EKE36901.1 - 4.8e-21 75.2 0.1 4.8e-21 75.2 0.1 2.3 2 1 0 2 2 2 1 Rap/ran-GAP Vta1 PF04652.16 EKE36902.1 - 7.2e-19 68.2 3.0 1.4e-18 67.2 3.0 1.5 1 0 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 EKE36902.1 - 1.4e-06 27.9 0.9 3.5e-06 26.6 0.9 1.6 1 0 0 1 1 1 1 Vta1 C-terminal domain FAM75 PF14650.6 EKE36902.1 - 0.00085 19.0 7.3 0.0016 18.1 7.3 1.4 1 0 0 1 1 1 1 FAM75 family EF-hand_1 PF00036.32 EKE36904.1 - 7.8e-28 93.9 5.2 1.3e-05 24.4 0.1 4.1 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 EKE36904.1 - 4.8e-27 92.2 6.1 1.4e-06 27.5 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EKE36904.1 - 1.8e-24 83.5 2.7 8.5e-05 22.2 0.1 4.1 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 EKE36904.1 - 4.2e-24 84.8 0.7 3.6e-12 46.6 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EKE36904.1 - 1.3e-19 69.7 7.0 4.1e-06 26.6 1.4 4.1 1 1 3 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EKE36904.1 - 1.1e-08 35.3 0.0 0.00079 19.7 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EKE36904.1 - 1.5e-05 24.7 0.5 0.55 10.1 0.0 3.6 4 0 0 4 4 4 2 EF hand EF-hand_4 PF12763.7 EKE36904.1 - 2.2e-05 24.4 1.8 0.083 12.9 0.1 2.9 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EKE36904.1 - 7.8e-05 22.8 2.5 10 6.4 0.0 4.0 3 1 1 4 4 4 1 Dockerin type I domain EF-hand_9 PF14658.6 EKE36904.1 - 0.031 14.6 0.2 0.21 11.9 0.0 2.3 3 0 0 3 3 3 0 EF-hand domain RelB_N PF18506.1 EKE36904.1 - 0.032 14.0 0.0 1.1 9.1 0.0 2.8 3 0 0 3 3 3 0 RelB Antitoxin alpha helical domain DUF5109 PF17134.4 EKE36904.1 - 0.058 13.3 0.2 4.3 7.3 0.0 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF5109) Bse634I PF07832.11 EKE36904.1 - 0.07 12.5 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Cfr10I/Bse634I restriction endonuclease Cro PF09048.10 EKE36904.1 - 0.11 12.5 0.1 3.8 7.6 0.0 2.6 2 0 0 2 2 2 0 Cro Nup54 PF13874.6 EKE36905.1 - 0.0039 17.3 4.0 0.004 17.3 0.5 2.1 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 SKA2 PF16740.5 EKE36905.1 - 0.022 14.5 9.0 0.051 13.4 2.0 2.6 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 COG5 PF10392.9 EKE36905.1 - 0.03 14.5 6.6 0.069 13.3 0.6 2.4 2 0 0 2 2 2 0 Golgi transport complex subunit 5 TTRAP PF14203.6 EKE36905.1 - 0.079 13.0 2.9 0.26 11.3 2.9 1.9 1 0 0 1 1 1 0 Putative tranposon-transfer assisting protein DpaA_N PF16924.5 EKE36905.1 - 0.14 12.3 0.8 1.5 8.9 0.2 2.4 2 0 0 2 2 2 0 Dipicolinate synthase subunit A N-terminal domain LPP PF04728.13 EKE36905.1 - 0.19 12.1 4.1 1.3 9.5 0.1 2.8 2 0 0 2 2 2 0 Lipoprotein leucine-zipper YtxH PF12732.7 EKE36905.1 - 0.2 12.2 0.8 1.5 9.4 0.8 2.3 1 1 0 1 1 1 0 YtxH-like protein RRP7 PF12923.7 EKE36905.1 - 0.21 11.7 3.1 4.8 7.3 0.1 2.5 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Pex24p PF06398.11 EKE36905.1 - 0.29 10.1 2.9 1.5 7.7 0.5 2.1 1 1 0 2 2 2 0 Integral peroxisomal membrane peroxin Nas2_N PF18265.1 EKE36905.1 - 0.82 9.6 4.5 4.6 7.2 0.2 3.4 3 1 0 3 3 3 0 Nas2 N_terminal domain DUF5320 PF17253.2 EKE36905.1 - 4.9 8.3 6.9 1.1 10.4 1.0 2.6 3 1 0 3 3 2 0 Family of unknown function (DUF5320) Nucleoporin_FG2 PF15967.5 EKE36905.1 - 5.2 5.5 13.3 11 4.5 13.3 1.4 1 0 0 1 1 1 0 Nucleoporin FG repeated region MRPL52 PF18699.1 EKE36905.1 - 5.7 7.2 9.0 11 6.3 0.6 2.6 2 0 0 2 2 2 0 Mitoribosomal protein mL52 bZIP_1 PF00170.21 EKE36905.1 - 6.7 6.9 7.8 18 5.6 1.5 2.7 2 0 0 2 2 2 0 bZIP transcription factor LRR_5 PF13306.6 EKE36906.1 - 8.8e-57 190.6 29.0 4.1e-33 114.1 10.0 2.5 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE36906.1 - 3.8e-14 52.2 3.0 0.00024 20.8 0.0 5.8 2 2 5 7 7 7 4 Leucine rich repeat PBD PF00786.28 EKE36907.1 - 7.5e-06 26.2 0.0 7.5e-06 26.2 0.0 4.0 5 0 0 5 5 5 1 P21-Rho-binding domain YxiJ PF14176.6 EKE36908.1 - 0.054 14.0 1.4 0.11 13.0 1.4 1.5 1 0 0 1 1 1 0 YxiJ-like protein DUF2465 PF10239.9 EKE36908.1 - 0.12 11.6 0.1 0.19 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2465) Beta_elim_lyase PF01212.21 EKE36908.1 - 0.18 11.0 0.0 0.23 10.7 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase RabGAP-TBC PF00566.18 EKE36909.1 - 4.5e-32 111.5 0.3 7.6e-32 110.7 0.3 1.4 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Ras PF00071.22 EKE36910.1 - 2.9e-40 137.5 2.2 3.3e-40 137.3 2.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE36910.1 - 4.1e-28 98.0 0.2 6.2e-28 97.4 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE36910.1 - 1.5e-14 53.8 0.5 1.9e-14 53.5 0.5 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE36910.1 - 1.4e-07 31.5 0.1 2.3e-07 30.9 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE36910.1 - 4.9e-06 26.1 0.1 6.6e-06 25.7 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE36910.1 - 6.1e-06 25.9 0.6 0.00081 19.0 0.6 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE36910.1 - 6.6e-05 22.4 0.5 7.8e-05 22.1 0.5 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE36910.1 - 0.00054 19.9 0.1 0.087 12.7 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 EKE36910.1 - 0.0006 19.9 0.1 0.0071 16.4 0.0 2.1 2 0 0 2 2 2 1 Dynamin family FeoB_N PF02421.18 EKE36910.1 - 0.014 14.9 0.5 0.043 13.4 0.4 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Septin PF00735.18 EKE36910.1 - 0.03 13.6 0.2 0.064 12.5 0.0 1.7 2 0 0 2 2 2 0 Septin PduV-EutP PF10662.9 EKE36910.1 - 0.067 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 EKE36910.1 - 0.12 12.8 0.1 0.53 10.7 0.1 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) WD40 PF00400.32 EKE36912.1 - 5.8e-34 115.6 18.0 0.00055 20.7 0.0 9.6 10 0 0 10 10 10 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE36912.1 - 7.5e-18 64.6 1.1 0.0067 16.7 0.0 7.9 3 2 6 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain Utp13 PF08625.11 EKE36912.1 - 7.3e-13 48.6 0.6 8e-12 45.3 0.6 2.3 1 1 0 1 1 1 1 Utp13 specific WD40 associated domain Ge1_WD40 PF16529.5 EKE36912.1 - 5.4e-06 25.6 2.8 0.23 10.4 0.0 4.9 3 2 2 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EKE36912.1 - 2.5e-05 23.1 3.2 0.38 9.3 0.0 4.7 3 1 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 EKE36912.1 - 2.6e-05 23.7 20.4 0.017 14.5 0.3 4.7 3 2 0 3 3 3 2 WD40-like domain ELYS-bb PF16687.5 EKE36912.1 - 0.0017 17.1 0.8 0.042 12.5 0.0 3.2 3 1 0 3 3 3 1 beta-propeller of ELYS nucleoporin Sulfotransfer_3 PF13469.6 EKE36913.1 - 2.5e-17 64.0 0.0 8.5e-17 62.3 0.0 1.9 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EKE36913.1 - 6e-06 25.9 0.0 1.4e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase domain BET PF17035.5 EKE36914.1 - 0.0039 17.3 0.9 0.011 15.9 0.9 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation ATG16 PF08614.11 EKE36915.1 - 1.5e-10 41.6 269.7 0.029 14.6 16.4 13.3 3 3 10 13 13 13 7 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EKE36915.1 - 8.8e-07 28.1 290.9 4.1e-05 22.6 26.4 11.9 1 1 10 12 12 12 7 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EKE36915.1 - 7.9e-05 22.7 275.1 0.0094 16.0 23.4 15.3 2 1 12 15 15 15 8 TPR/MLP1/MLP2-like protein HALZ PF02183.18 EKE36915.1 - 0.0001 22.5 18.5 0.00029 21.0 7.2 20.2 20 4 2 22 22 20 2 Homeobox associated leucine zipper DUF3584 PF12128.8 EKE36915.1 - 0.00092 16.9 22.8 0.00092 16.9 22.8 6.7 1 1 4 6 6 6 4 Protein of unknown function (DUF3584) HOOK PF05622.12 EKE36915.1 - 0.0018 16.5 18.7 0.0018 16.5 18.7 7.9 1 1 6 7 7 7 2 HOOK protein ADIP PF11559.8 EKE36915.1 - 0.0018 18.4 3.2 0.0018 18.4 3.2 17.1 1 1 15 17 17 17 6 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 EKE36915.1 - 0.0021 18.1 28.2 0.0021 18.1 28.2 15.0 1 1 14 16 16 15 5 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cnn_1N PF07989.11 EKE36915.1 - 0.0091 16.1 3.6 0.0091 16.1 3.6 21.1 5 3 13 18 18 14 4 Centrosomin N-terminal motif 1 DUF1664 PF07889.12 EKE36915.1 - 0.066 13.2 210.2 0.16 12.0 8.1 17.8 3 3 12 18 18 18 0 Protein of unknown function (DUF1664) Rad10 PF03834.14 EKE36915.1 - 0.12 12.3 3.0 0.19 11.8 0.5 2.8 2 0 0 2 2 2 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Fib_alpha PF08702.10 EKE36915.1 - 0.13 12.4 229.1 0.059 13.6 14.9 14.9 3 3 10 15 15 15 0 Fibrinogen alpha/beta chain family AAA_13 PF13166.6 EKE36915.1 - 0.23 10.1 246.2 0.041 12.6 21.8 10.6 1 1 10 11 11 11 0 AAA domain Fez1 PF06818.15 EKE36915.1 - 0.91 9.9 249.8 0.78 10.2 14.5 11.6 1 1 11 12 12 12 0 Fez1 ERM PF00769.19 EKE36915.1 - 0.98 9.2 267.2 0.02 14.7 11.7 11.8 1 1 11 12 12 12 0 Ezrin/radixin/moesin family Actin PF00022.19 EKE36916.1 - 9.5e-32 110.1 0.0 1.5e-17 63.4 0.0 2.9 1 1 1 2 2 2 2 Actin PAP2 PF01569.21 EKE36918.1 - 7.9e-18 64.5 5.0 7.9e-18 64.5 5.0 2.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EKE36918.1 - 7.1e-08 32.4 5.2 7.1e-08 32.4 5.2 2.3 2 1 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 EKE36918.1 - 3.1 8.4 16.7 0.055 14.0 2.7 3.3 3 0 0 3 3 3 0 PAP2 superfamily C-terminal DASH_Duo1 PF08651.10 EKE36919.1 - 0.011 15.5 4.0 0.13 12.0 0.2 3.4 3 0 0 3 3 3 0 DASH complex subunit Duo1 Anti-adapt_IraP PF10796.9 EKE36919.1 - 0.12 12.9 0.5 14 6.3 0.1 2.5 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein DUF5446 PF17522.2 EKE36919.1 - 0.52 10.5 2.2 17 5.7 0.2 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5446) MCM PF00493.23 EKE36920.1 - 1.3e-90 302.4 0.1 2.7e-90 301.4 0.0 1.5 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EKE36920.1 - 8.6e-27 93.5 3.0 1.7e-26 92.5 3.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EKE36920.1 - 1.4e-25 89.6 7.3 1.9e-25 89.1 1.4 2.7 3 0 0 3 3 2 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EKE36920.1 - 1.4e-09 37.7 1.4 4.2e-06 26.3 0.0 2.9 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EKE36920.1 - 4.1e-08 33.3 0.0 1.1e-07 32.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EKE36920.1 - 2.7e-06 27.2 0.0 1e-05 25.4 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 EKE36920.1 - 6.2e-06 26.7 0.5 0.00013 22.4 0.0 2.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EKE36920.1 - 0.0032 17.2 0.1 0.017 14.9 0.1 2.1 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EKE36920.1 - 0.0033 17.8 0.7 0.021 15.2 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain RNA_helicase PF00910.22 EKE36920.1 - 0.0035 17.7 0.2 6.9 7.1 0.0 3.3 2 1 0 2 2 2 1 RNA helicase AAA_30 PF13604.6 EKE36920.1 - 0.0073 16.0 0.1 0.03 14.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EKE36920.1 - 0.0085 16.4 0.5 0.19 12.0 0.0 3.3 3 1 0 3 3 2 1 AAA domain Sigma54_activat PF00158.26 EKE36920.1 - 0.016 14.9 0.0 0.11 12.2 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain NTPase_1 PF03266.15 EKE36920.1 - 0.026 14.4 0.4 0.84 9.5 0.0 2.6 1 1 0 2 2 2 0 NTPase AAA_29 PF13555.6 EKE36920.1 - 0.046 13.5 0.1 0.23 11.2 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain HypA PF01155.19 EKE36920.1 - 0.051 13.6 1.6 0.16 12.0 1.6 1.8 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FtsK_SpoIIIE PF01580.18 EKE36920.1 - 0.11 11.9 0.0 0.11 11.9 0.0 1.9 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_19 PF13245.6 EKE36920.1 - 0.16 12.3 1.0 5.9 7.2 0.0 3.4 3 1 0 4 4 4 0 AAA domain ABC_tran PF00005.27 EKE36920.1 - 0.25 11.9 1.8 1.4 9.4 0.0 2.8 3 1 0 3 3 3 0 ABC transporter T4_baseplate PF12322.8 EKE36920.1 - 7 6.1 9.5 9.5 5.6 0.7 3.4 3 1 0 3 3 3 0 T4 bacteriophage base plate protein Acetyltransf_1 PF00583.25 EKE36921.1 - 3.4e-11 43.4 0.0 6.9e-11 42.4 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EKE36921.1 - 2.1e-08 34.1 0.1 3.3e-08 33.5 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EKE36921.1 - 1.3e-05 25.5 0.1 2.2e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EKE36921.1 - 0.0012 18.8 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein TIP120 PF08623.10 EKE36922.1 - 6.1e-36 123.7 0.5 6.1e-36 123.7 0.5 4.5 5 0 0 5 5 5 1 TATA-binding protein interacting (TIP20) HEAT PF02985.22 EKE36922.1 - 5.1e-12 45.0 1.7 0.014 15.6 0.0 7.4 9 0 0 9 9 9 3 HEAT repeat HEAT_EZ PF13513.6 EKE36922.1 - 1.5e-08 34.9 0.4 0.32 11.5 0.0 6.5 6 1 1 7 7 7 2 HEAT-like repeat HEAT_2 PF13646.6 EKE36922.1 - 1.4e-06 28.6 0.0 0.38 11.2 0.0 4.5 4 0 0 4 4 4 2 HEAT repeats Arm PF00514.23 EKE36922.1 - 0.067 13.3 0.1 22 5.3 0.0 4.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat INTS5_N PF14837.6 EKE36922.1 - 1.1 8.8 6.7 1.9 8.0 2.1 3.4 3 1 0 3 3 3 0 Integrator complex subunit 5 N-terminus TLD PF07534.16 EKE36923.1 - 0.00013 22.2 1.0 0.00066 19.9 0.8 1.8 1 1 1 2 2 2 1 TLD FAM72 PF14976.6 EKE36923.1 - 0.0012 19.1 0.1 0.0015 18.7 0.1 1.2 1 0 0 1 1 1 1 FAM72 protein Ribosomal_L22 PF00237.19 EKE36924.1 - 1.5e-33 115.1 0.2 2e-33 114.7 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e CTP_transf_1 PF01148.20 EKE36925.1 - 9.8e-40 137.0 22.5 3.4e-39 135.2 22.5 1.7 1 1 0 1 1 1 1 Cytidylyltransferase family Ribosomal_S26e PF01283.19 EKE36926.1 - 8.4e-49 164.5 12.0 1.3e-48 163.9 12.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S26e SRP19 PF01922.17 EKE36926.1 - 0.0072 17.2 1.0 0.012 16.5 1.0 1.5 1 1 0 1 1 1 1 SRP19 protein Mu-like_Com PF10122.9 EKE36926.1 - 0.009 15.4 0.2 0.009 15.4 0.2 1.6 2 0 0 2 2 2 1 Mu-like prophage protein Com Fer4_7 PF12838.7 EKE36926.1 - 0.032 14.8 4.7 0.86 10.2 3.8 2.5 1 1 2 3 3 3 0 4Fe-4S dicluster domain Fer4 PF00037.27 EKE36926.1 - 0.21 11.5 5.0 1.2 9.0 1.0 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 EKE36926.1 - 0.28 11.8 4.3 0.19 12.3 2.3 1.8 2 1 0 2 2 2 0 4Fe-4S dicluster domain zf-ribbon_3 PF13248.6 EKE36926.1 - 0.44 10.0 4.5 1.1 8.7 1.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Fer4_2 PF12797.7 EKE36926.1 - 0.6 10.3 4.2 3.3 8.0 1.6 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_4 PF12800.7 EKE36926.1 - 1.4 9.6 5.5 3.2 8.5 2.2 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain PRMT5 PF05185.16 EKE36927.1 - 4.3e-56 189.5 0.1 7e-56 188.8 0.1 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EKE36927.1 - 3.3e-44 150.9 3.4 3.3e-44 150.9 3.4 1.8 2 0 0 2 2 2 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 EKE36927.1 - 5.4e-15 55.3 6.7 1.7e-14 53.7 6.6 1.7 1 1 0 1 1 1 1 PRMT5 TIM barrel domain TehB PF03848.14 EKE36927.1 - 0.0096 15.4 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_31 PF13847.6 EKE36927.1 - 0.016 15.0 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 EKE36927.1 - 0.055 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein S_layer_C PF05124.12 EKE36927.1 - 0.1 12.5 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 S-layer like family, C-terminal region WH2 PF02205.20 EKE36928.1 - 2e-14 52.9 7.2 1.6e-07 30.9 0.7 3.2 3 0 0 3 3 3 3 WH2 motif Thymosin PF01290.20 EKE36928.1 - 0.3 10.9 4.3 3.4 7.5 0.7 2.6 2 1 0 2 2 2 0 Thymosin beta-4 family UCH PF00443.29 EKE36929.1 - 4e-24 85.5 8.4 4e-24 85.5 8.4 3.5 3 2 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase Pkinase PF00069.25 EKE36930.1 - 5.6e-48 163.6 0.7 5.8e-47 160.3 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE36930.1 - 1.2e-18 67.3 0.0 2.5e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EKE36930.1 - 0.00064 19.7 0.0 0.0022 18.0 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EKE36930.1 - 0.0064 16.1 0.2 0.0064 16.1 0.2 2.1 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 EKE36930.1 - 0.066 12.8 2.6 0.15 11.6 0.2 2.6 2 1 1 3 3 3 0 Choline/ethanolamine kinase DUF4603 PF15376.6 EKE36930.1 - 0.087 10.2 0.2 0.14 9.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Y_phosphatase PF00102.27 EKE36931.1 - 0.0037 16.9 0.0 0.0084 15.7 0.0 1.6 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EKE36931.1 - 0.021 14.8 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family IpgD PF05925.12 EKE36931.1 - 0.058 12.0 0.4 0.22 10.1 0.1 1.9 1 1 0 2 2 2 0 Enterobacterial virulence protein IpgD Spc29 PF17082.5 EKE36932.1 - 0.0027 17.6 6.2 0.062 13.1 3.5 2.0 1 1 1 2 2 2 1 Spindle Pole Component 29 DUF5344 PF17279.2 EKE36932.1 - 0.0039 17.7 7.8 0.095 13.3 2.3 2.1 1 1 1 2 2 2 2 Family of unknown function (DUF5344) Cdh1_DBD_1 PF18196.1 EKE36932.1 - 0.0053 17.1 1.6 0.0064 16.8 1.6 1.1 1 0 0 1 1 1 1 Chromodomain helicase DNA-binding domain 1 Lebercilin PF15619.6 EKE36932.1 - 0.0061 16.2 5.3 0.0072 16.0 5.3 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Phasin_2 PF09361.10 EKE36932.1 - 0.012 15.8 2.0 1.1 9.5 0.2 2.0 1 1 1 2 2 2 0 Phasin protein DHR10 PF18595.1 EKE36932.1 - 0.012 15.6 2.8 0.017 15.2 2.8 1.3 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain Phage_HK97_TLTM PF06120.11 EKE36932.1 - 0.017 14.3 3.9 0.018 14.3 3.9 1.1 1 0 0 1 1 1 0 Tail length tape measure protein DUF3450 PF11932.8 EKE36932.1 - 0.018 14.3 3.7 0.02 14.2 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) CorA PF01544.18 EKE36932.1 - 0.019 14.3 0.8 0.019 14.3 0.8 1.0 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein BLOC1_2 PF10046.9 EKE36932.1 - 0.021 15.1 6.3 0.024 14.9 6.3 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Med9 PF07544.13 EKE36932.1 - 0.023 14.8 3.0 0.034 14.2 2.9 1.4 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 CLZ PF16526.5 EKE36932.1 - 0.023 15.0 2.9 0.027 14.8 1.3 1.7 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FliD_C PF07195.12 EKE36932.1 - 0.024 14.1 4.6 0.027 13.9 4.6 1.1 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus ABC_tran_Xtn PF12848.7 EKE36932.1 - 0.026 14.5 0.3 0.037 14.1 0.3 1.2 1 0 0 1 1 1 0 ABC transporter AAR2 PF05282.11 EKE36932.1 - 0.029 13.8 2.0 0.031 13.7 2.0 1.1 1 0 0 1 1 1 0 AAR2 protein DUF16 PF01519.16 EKE36932.1 - 0.054 14.0 5.5 0.063 13.8 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 Syntaxin-6_N PF09177.11 EKE36932.1 - 0.058 14.0 2.6 0.07 13.7 2.6 1.1 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Prefoldin PF02996.17 EKE36932.1 - 0.066 13.1 5.2 0.089 12.7 4.6 1.6 1 1 0 1 1 1 0 Prefoldin subunit DUF2120 PF09893.9 EKE36932.1 - 0.09 12.9 3.4 0.11 12.6 3.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) DUF1664 PF07889.12 EKE36932.1 - 0.09 12.8 2.2 0.11 12.6 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3782 PF12644.7 EKE36932.1 - 0.1 12.8 0.6 0.26 11.5 0.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3782) Fib_alpha PF08702.10 EKE36932.1 - 0.12 12.5 5.5 0.14 12.3 5.5 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.8 EKE36932.1 - 0.14 12.2 7.8 0.36 10.9 7.7 1.8 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF745 PF05335.13 EKE36932.1 - 0.16 11.7 1.6 0.18 11.5 1.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF745) zf-CCCH_6 PF18585.1 EKE36932.1 - 0.16 11.8 1.2 0.3 11.0 0.4 1.9 1 1 1 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 SseC PF04888.12 EKE36932.1 - 0.23 11.0 2.9 0.24 11.0 1.9 1.4 1 1 0 1 1 1 0 Secretion system effector C (SseC) like family LMBR1 PF04791.16 EKE36932.1 - 0.51 9.2 3.4 0.51 9.2 3.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein KIP1 PF07765.12 EKE36932.1 - 0.84 9.8 5.4 2.5 8.3 5.2 1.7 1 1 1 2 2 2 0 KIP1-like protein DASH_Dam1 PF08653.10 EKE36932.1 - 3.8 7.4 6.8 2.2 8.1 2.5 2.3 1 1 1 2 2 2 0 DASH complex subunit Dam1 RFC1 PF08519.12 EKE36933.1 - 4.8e-21 75.5 0.2 4.8e-21 75.5 0.2 2.3 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EKE36933.1 - 2.2e-15 56.8 0.6 3.4e-14 53.0 0.0 3.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EKE36933.1 - 6.9e-11 42.7 0.1 2.3e-10 41.0 0.1 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EKE36933.1 - 1.8e-09 37.8 0.1 1.6e-08 34.7 0.0 2.5 1 1 1 2 2 2 1 Rad17 P-loop domain PTCB-BRCT PF12738.7 EKE36933.1 - 3.7e-05 23.6 0.2 0.00032 20.6 0.0 2.4 2 0 0 2 2 2 1 twin BRCT domain RuvB_N PF05496.12 EKE36933.1 - 5.8e-05 22.9 0.0 0.00015 21.5 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EKE36933.1 - 6.3e-05 23.0 0.0 0.00029 20.9 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EKE36933.1 - 8e-05 23.2 0.1 0.00047 20.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain BRCT_2 PF16589.5 EKE36933.1 - 0.0031 17.9 0.1 0.017 15.6 0.1 2.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Zeta_toxin PF06414.12 EKE36933.1 - 0.0056 16.0 0.0 0.019 14.3 0.0 1.9 1 0 0 1 1 1 1 Zeta toxin AAA_assoc_2 PF16193.5 EKE36933.1 - 0.013 15.8 0.0 0.056 13.8 0.0 2.1 1 0 0 1 1 1 0 AAA C-terminal domain AAA_16 PF13191.6 EKE36933.1 - 0.023 15.1 0.0 0.054 13.9 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EKE36933.1 - 0.044 13.9 0.3 0.24 11.5 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 EKE36933.1 - 0.044 13.4 0.1 0.092 12.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EKE36933.1 - 0.046 14.1 1.2 3.2 8.1 0.2 3.2 3 1 0 3 3 3 0 AAA domain TsaE PF02367.17 EKE36933.1 - 0.061 13.3 0.2 0.3 11.1 0.0 2.2 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EKE36933.1 - 0.1 12.9 1.4 1.1 9.5 0.1 2.8 2 1 0 2 2 2 0 AAA domain OGFr_N PF04664.13 EKE36934.1 - 1.4e-27 96.6 4.5 1.4e-27 96.6 4.5 1.8 2 0 0 2 2 2 1 Opioid growth factor receptor (OGFr) conserved region Ribosomal_S8e PF01201.22 EKE36934.1 - 2.5 8.3 14.5 14 5.9 14.5 2.1 1 1 0 1 1 1 0 Ribosomal protein S8e YlzJ PF14035.6 EKE36934.1 - 3.7 7.8 8.5 0.66 10.2 2.7 2.4 2 0 0 2 2 2 0 YlzJ-like protein PP2C PF00481.21 EKE36935.1 - 5e-44 150.9 0.0 7.1e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 EKE36935.1 - 3.9e-42 141.5 105.3 7.9e-06 26.1 5.1 13.0 6 2 7 15 15 15 14 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE36935.1 - 1.1e-41 140.4 87.8 1.3e-07 31.2 2.8 13.1 4 1 7 14 14 14 13 Leucine rich repeat LRR_9 PF14580.6 EKE36935.1 - 2e-07 30.7 41.5 0.0034 16.9 1.3 6.0 1 1 4 6 6 6 5 Leucine-rich repeat PP2C_2 PF13672.6 EKE36935.1 - 0.031 13.9 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C LRR_6 PF13516.6 EKE36935.1 - 0.048 13.7 74.4 2.2 8.6 0.1 15.6 15 0 0 15 15 15 0 Leucine Rich repeat LRR_1 PF00560.33 EKE36935.1 - 0.084 13.5 89.1 5.4 8.0 0.2 19.2 15 3 2 17 17 17 0 Leucine Rich Repeat Rap_GAP PF02145.15 EKE36936.1 - 1.3e-47 161.7 0.0 4.1e-47 160.1 0.0 1.9 1 0 0 1 1 1 1 Rap/ran-GAP DcuA_DcuB PF03605.14 EKE36937.1 - 0.008 15.1 0.2 0.0097 14.8 0.2 1.1 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter COX2_TM PF02790.15 EKE36937.1 - 0.019 15.1 0.1 0.03 14.5 0.1 1.4 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain DUF1146 PF06612.11 EKE36937.1 - 0.04 14.0 0.4 0.04 14.0 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1146) Totivirus_coat PF05518.11 EKE36937.1 - 7.3 4.5 8.8 8.2 4.3 8.8 1.0 1 0 0 1 1 1 0 Totivirus coat protein Sulfotransfer_3 PF13469.6 EKE36939.1 - 8.8e-18 65.5 0.0 2.5e-17 64.0 0.0 1.8 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EKE36939.1 - 0.00013 21.6 1.0 0.00072 19.1 1.0 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Rap_GAP PF02145.15 EKE36940.1 - 1.2e-39 135.8 0.3 1.2e-39 135.8 0.3 2.3 2 0 0 2 2 2 1 Rap/ran-GAP UCH PF00443.29 EKE36940.1 - 0.0085 15.6 1.4 0.14 11.7 0.0 3.3 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DAPDH_C PF16654.5 EKE36940.1 - 0.21 11.4 4.1 0.24 11.2 2.0 2.2 2 0 0 2 2 2 0 Diaminopimelic acid dehydrogenase C-terminal domain ABC_tran PF00005.27 EKE36941.1 - 4.2e-50 169.8 0.3 7.4e-31 107.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EKE36941.1 - 1.2e-38 133.4 38.9 6.5e-24 85.0 16.6 2.8 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 EKE36941.1 - 1.2e-09 38.5 0.3 0.37 10.6 0.0 4.9 3 2 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EKE36941.1 - 9.7e-08 31.7 8.6 0.12 11.8 0.0 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EKE36941.1 - 1.3e-07 31.7 1.7 0.0014 18.5 0.4 3.1 2 1 0 2 2 2 2 RsgA GTPase T2SSE PF00437.20 EKE36941.1 - 6.9e-07 28.6 0.1 0.0022 17.1 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein Dynamin_N PF00350.23 EKE36941.1 - 7e-06 26.2 0.1 0.057 13.5 0.0 2.8 2 0 0 2 2 2 2 Dynamin family AAA_29 PF13555.6 EKE36941.1 - 4.1e-05 23.2 0.4 0.13 12.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EKE36941.1 - 4.7e-05 23.4 7.0 0.099 12.7 0.2 3.6 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_7 PF12775.7 EKE36941.1 - 5.1e-05 22.9 0.5 0.021 14.3 0.1 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_16 PF13191.6 EKE36941.1 - 0.00013 22.4 0.0 0.15 12.4 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain cobW PF02492.19 EKE36941.1 - 0.00024 20.7 0.4 0.075 12.6 0.1 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EKE36941.1 - 0.00034 19.9 1.7 0.076 12.2 0.0 2.9 3 0 0 3 3 3 1 NB-ARC domain AAA_22 PF13401.6 EKE36941.1 - 0.00042 20.6 7.3 0.12 12.7 0.3 3.7 3 2 0 3 3 2 2 AAA domain Zeta_toxin PF06414.12 EKE36941.1 - 0.0005 19.4 0.0 0.041 13.2 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.12 EKE36941.1 - 0.00056 19.9 0.4 0.14 12.1 0.0 2.9 2 0 0 2 2 2 1 NACHT domain KAP_NTPase PF07693.14 EKE36941.1 - 0.001 18.4 0.0 0.91 8.7 0.0 2.5 2 0 0 2 2 2 2 KAP family P-loop domain PduV-EutP PF10662.9 EKE36941.1 - 0.0011 18.8 1.7 0.03 14.1 0.1 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP-synt_ab PF00006.25 EKE36941.1 - 0.0022 17.7 0.4 1.4 8.6 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.6 EKE36941.1 - 0.0029 18.2 0.0 1.2 9.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain Septin PF00735.18 EKE36941.1 - 0.0034 16.7 0.7 0.26 10.5 0.1 2.4 2 0 0 2 2 2 1 Septin Roc PF08477.13 EKE36941.1 - 0.0036 17.5 0.4 1.7 8.9 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 EKE36941.1 - 0.0047 16.9 0.4 0.62 9.9 0.0 2.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea FtsK_SpoIIIE PF01580.18 EKE36941.1 - 0.0053 16.1 0.3 0.69 9.2 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family DUF87 PF01935.17 EKE36941.1 - 0.0056 16.8 0.9 0.03 14.4 0.2 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain AAA PF00004.29 EKE36941.1 - 0.0068 16.8 1.3 0.16 12.4 0.1 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 EKE36941.1 - 0.0083 16.7 10.3 0.036 14.6 1.1 3.5 3 1 0 3 3 2 1 AAA domain PIF1 PF05970.14 EKE36941.1 - 0.0093 15.2 0.3 0.56 9.3 0.1 2.4 2 0 0 2 2 2 1 PIF1-like helicase Sigma54_activat PF00158.26 EKE36941.1 - 0.011 15.4 0.1 2.3 7.9 0.1 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 EKE36941.1 - 0.021 14.5 1.0 5.6 6.6 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 EKE36941.1 - 0.024 15.0 0.1 10 6.6 0.0 2.9 2 0 0 2 2 2 0 RNA helicase TsaE PF02367.17 EKE36941.1 - 0.025 14.6 0.2 0.42 10.6 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EKE36941.1 - 0.044 12.9 0.1 5.3 6.1 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) GTP_EFTU PF00009.27 EKE36941.1 - 0.052 13.1 0.3 1.1 8.7 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EKE36941.1 - 0.059 13.5 0.2 4.5 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EKE36941.1 - 0.088 13.1 0.7 1.5 9.2 0.0 2.8 2 1 0 2 2 2 0 AAA domain DEAD PF00270.29 EKE36941.1 - 0.091 12.5 0.3 4.7 6.9 0.1 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase MobB PF03205.14 EKE36941.1 - 0.12 12.2 1.0 2.7 7.9 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.6 EKE36941.1 - 0.2 11.2 0.0 4.1 6.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain Transport_MerF PF11431.8 EKE36941.1 - 0.23 11.4 3.2 0.59 10.1 0.4 3.3 2 0 0 2 2 2 0 Membrane transport protein MerF AAA_30 PF13604.6 EKE36941.1 - 0.25 11.1 0.0 9.6 5.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EKE36941.1 - 0.36 10.6 2.7 10 5.8 0.1 3.0 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 EKE36941.1 - 0.58 10.0 7.1 0.48 10.3 0.1 3.3 4 0 0 4 4 3 0 NTPase Rad17 PF03215.15 EKE36941.1 - 1.8 8.5 8.6 1.5 8.7 0.1 4.1 4 0 0 4 4 4 0 Rad17 P-loop domain Ribosomal_S17_N PF16205.5 EKE36942.1 - 7.7e-27 93.5 0.4 7.7e-27 93.5 0.4 1.6 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EKE36942.1 - 1.8e-25 88.8 2.0 3.6e-25 87.8 2.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 Mo-nitro_C PF06967.11 EKE36942.1 - 0.074 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Mo-dependent nitrogenase C-terminus Pkinase_Tyr PF07714.17 EKE36943.1 - 1.3e-46 159.0 0.0 2.2e-46 158.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE36943.1 - 2.8e-40 138.4 0.0 4.4e-40 137.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EKE36944.1 - 9.2e-30 100.1 10.2 0.00019 21.4 0.0 11.7 12 0 0 12 12 12 6 HEAT repeat HEAT_2 PF13646.6 EKE36944.1 - 3.6e-15 56.1 0.0 0.00027 21.3 0.0 6.7 2 1 7 9 9 9 6 HEAT repeats Vac14_Fab1_bd PF12755.7 EKE36944.1 - 4.7e-08 33.5 5.3 0.22 12.1 0.0 5.8 3 1 2 5 5 5 3 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EKE36944.1 - 2.6e-07 29.6 10.2 0.00012 20.8 0.5 3.6 2 1 1 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.7 EKE36944.1 - 1.4e-06 28.4 6.9 0.0027 17.8 0.0 3.8 2 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EKE36944.1 - 0.0008 19.0 2.8 0.13 11.8 1.6 3.8 2 1 1 3 3 3 1 CLASP N terminal Condensin2nSMC PF12422.8 EKE36944.1 - 0.022 15.0 1.2 0.076 13.2 0.1 2.3 1 1 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit DNA_alkylation PF08713.11 EKE36944.1 - 0.028 14.2 0.0 0.32 10.7 0.0 2.5 2 1 1 3 3 3 0 DNA alkylation repair enzyme TFCD_C PF12612.8 EKE36944.1 - 0.048 13.5 0.3 22 4.8 0.0 3.8 3 1 0 3 3 3 0 Tubulin folding cofactor D C terminal HEAT_EZ PF13513.6 EKE36944.1 - 0.05 14.1 0.3 14 6.3 0.0 4.4 4 0 0 4 4 4 0 HEAT-like repeat Arm PF00514.23 EKE36944.1 - 0.13 12.3 1.0 47 4.2 0.0 4.5 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Pyrophosphatase PF00719.19 EKE36945.1 - 1.7e-44 151.4 0.5 2.3e-44 151.0 0.5 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase DUF4974 PF16344.5 EKE36945.1 - 0.14 12.2 0.5 0.37 10.8 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4974) Kinesin PF00225.23 EKE36946.1 - 3.3e-90 302.4 0.4 3.3e-90 302.4 0.4 3.7 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EKE36946.1 - 7.1e-31 107.1 0.6 7.1e-31 107.1 0.6 5.0 2 1 0 2 2 2 1 Microtubule binding DUF4172 PF13776.6 EKE36946.1 - 0.72 10.2 7.0 0.59 10.5 0.4 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4172) Arm PF00514.23 EKE36947.1 - 3.1e-05 23.8 0.0 0.25 11.4 0.0 4.6 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat DEK_C PF08766.11 EKE36947.1 - 0.26 11.3 0.1 0.26 11.3 0.1 2.5 3 0 0 3 3 3 0 DEK C terminal domain Pkinase PF00069.25 EKE36948.1 - 4.5e-08 32.8 0.2 4.5e-08 32.8 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE36948.1 - 0.00044 19.6 0.0 0.00044 19.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE36948.1 - 0.024 13.4 0.4 0.024 13.4 0.4 1.0 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EKE36948.1 - 0.053 12.5 0.4 0.053 12.5 0.4 1.0 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 EKE36948.1 - 0.067 13.1 0.1 0.067 13.1 0.1 1.0 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EKE36948.1 - 0.17 11.2 0.0 0.17 11.2 0.0 1.0 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EKE36949.1 - 1.6e-12 47.3 0.1 2.2e-12 46.9 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE36949.1 - 1.9e-11 43.7 0.2 2.2e-11 43.5 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase PAP2 PF01569.21 EKE36950.1 - 3e-07 30.3 0.4 3e-07 30.3 0.4 2.2 2 1 0 2 2 2 1 PAP2 superfamily NDUF_B4 PF07225.12 EKE36950.1 - 0.1 12.5 0.5 0.36 10.7 0.1 2.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Snf7 PF03357.21 EKE36951.1 - 2.3e-24 85.9 33.3 2.3e-24 85.9 33.3 1.3 1 1 0 1 1 1 1 Snf7 DUF1771 PF08590.10 EKE36951.1 - 0.055 13.9 3.9 0.16 12.4 3.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) TPR_21 PF09976.9 EKE36951.1 - 0.61 9.8 13.8 0.17 11.6 5.8 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain PspA_IM30 PF04012.12 EKE36951.1 - 3.8 7.0 30.4 18 4.8 18.0 3.0 1 1 1 2 2 2 0 PspA/IM30 family WGG PF10273.9 EKE36952.1 - 2.3e-17 63.4 0.0 5.1e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 BUD22 PF09073.10 EKE36952.1 - 0.13 11.5 17.5 0.13 11.5 17.5 1.1 1 0 0 1 1 1 0 BUD22 DUF913 PF06025.12 EKE36952.1 - 0.24 10.4 4.5 0.35 9.8 4.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 EKE36952.1 - 0.37 9.0 15.4 0.37 9.0 15.4 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EKE36952.1 - 2.6 7.4 27.0 3 7.2 27.0 1.2 1 0 0 1 1 1 0 SDA1 RRN3 PF05327.11 EKE36952.1 - 2.7 6.4 13.7 3.1 6.2 13.7 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CobT PF06213.12 EKE36952.1 - 5.1 6.4 20.9 6.5 6.1 20.9 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT YL1 PF05764.13 EKE36952.1 - 5.2 7.1 22.6 8 6.5 22.6 1.5 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 EKE36952.1 - 6.6 4.8 28.3 7.2 4.7 28.3 1.1 1 0 0 1 1 1 0 Nop14-like family UPF0047 PF01894.17 EKE36953.1 - 2.3e-38 130.9 0.0 2.7e-38 130.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 RabGAP-TBC PF00566.18 EKE36954.1 - 4.9e-21 75.4 9.5 4.9e-21 75.4 9.5 3.6 2 1 0 2 2 2 1 Rab-GTPase-TBC domain CK1gamma_C PF12605.8 EKE36954.1 - 0.54 11.5 3.9 1 10.5 3.9 1.4 1 0 0 1 1 1 0 Casein kinase 1 gamma C terminal CHD5 PF04420.14 EKE36954.1 - 0.57 10.0 5.4 1.5 8.6 0.0 2.4 2 0 0 2 2 2 0 CHD5-like protein Lactamase_B_2 PF12706.7 EKE36955.1 - 1.8e-15 57.0 0.0 2.3e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PDEase_II PF02112.15 EKE36955.1 - 1.2e-09 37.8 4.0 2.1e-06 27.1 4.0 2.2 1 1 0 1 1 1 1 cAMP phosphodiesterases class-II Lactamase_B PF00753.27 EKE36955.1 - 1.2e-08 35.2 0.0 4.1e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily VWA_2 PF13519.6 EKE36957.1 - 0.00038 21.1 0.0 0.0009 19.9 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Biliv-reduc_cat PF09166.10 EKE36957.1 - 0.049 13.9 0.3 0.1 12.9 0.3 1.4 1 0 0 1 1 1 0 Biliverdin reductase, catalytic dCMP_cyt_deam_1 PF00383.23 EKE36958.1 - 5.5e-25 87.2 5.0 7.7e-25 86.7 5.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EKE36958.1 - 1.2e-23 83.4 1.7 1.5e-23 83.1 1.7 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 EKE36958.1 - 0.00054 20.1 2.2 0.00056 20.0 1.1 1.5 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 EKE36958.1 - 0.0006 19.9 0.5 0.0012 18.9 0.5 1.5 1 0 0 1 1 1 1 APOBEC3 APOBEC2 PF18772.1 EKE36958.1 - 0.0096 16.0 0.6 0.016 15.2 0.6 1.3 1 0 0 1 1 1 1 APOBEC2 APOBEC4_like PF18774.1 EKE36958.1 - 0.018 15.0 2.4 0.018 14.9 1.5 1.6 1 1 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase NAD1 PF18778.1 EKE36958.1 - 0.018 15.2 1.1 0.018 15.2 1.1 1.5 2 0 0 2 2 2 0 Novel AID APOBEC clade 1 NAD2 PF18782.1 EKE36958.1 - 0.024 14.7 0.4 0.042 14.0 0.4 1.3 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 Inv-AAD PF18785.1 EKE36958.1 - 0.025 14.5 5.8 0.1 12.5 5.8 1.8 1 1 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase Bd3614-deam PF14439.6 EKE36958.1 - 0.47 10.5 5.0 6.6 6.8 2.9 2.1 1 1 1 2 2 2 0 Bd3614-like deaminase SUR7 PF06687.12 EKE36959.1 - 0.00013 21.7 11.1 0.00013 21.7 11.1 2.1 1 1 1 2 2 2 1 SUR7/PalI family DUF973 PF06157.11 EKE36959.1 - 0.4 9.7 14.5 1.1 8.3 13.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF973) 7tm_7 PF08395.12 EKE36959.1 - 4.5 6.4 14.6 0.1 11.8 7.8 1.8 2 1 0 2 2 2 0 7tm Chemosensory receptor DUF4064 PF13273.6 EKE36959.1 - 8.6 6.7 23.5 5.1 7.4 2.9 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF4064) RRM_1 PF00076.22 EKE36960.1 - 1.2e-15 57.1 0.0 1.7e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EKE36960.1 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EKE36960.1 - 0.017 15.1 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Glyco_transf_20 PF00982.21 EKE36960.1 - 0.05 12.3 0.1 0.068 11.8 0.1 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 20 GAPES2 PF17156.4 EKE36961.1 - 0.00054 19.8 0.3 0.00097 19.0 0.3 1.4 1 0 0 1 1 1 1 Gammaproteobacterial periplasmic sensor domain SPT6_acidic PF14632.6 EKE36961.1 - 0.15 12.7 5.6 0.26 11.9 5.6 1.3 1 0 0 1 1 1 0 Acidic N-terminal SPT6 DCB PF16213.5 EKE36963.1 - 3.9e-11 42.9 6.3 1.7e-10 40.9 3.6 3.2 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 FAD_SOX PF18371.1 EKE36963.1 - 0.034 14.5 0.1 0.24 11.8 0.1 2.6 1 0 0 1 1 1 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase UPF0184 PF03670.13 EKE36963.1 - 0.22 12.0 1.1 24 5.4 0.0 3.8 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0184) Lyase_8_N PF08124.11 EKE36964.1 - 0.048 12.6 1.1 0.09 11.7 1.1 1.5 1 1 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain DHHC PF01529.20 EKE36965.1 - 1.5e-29 102.8 21.8 1.5e-29 102.8 21.8 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase WWE PF02825.20 EKE36967.1 - 1.9e-19 70.0 6.2 4e-14 52.9 2.8 2.2 2 0 0 2 2 2 2 WWE domain Porin_O_P PF07396.11 EKE36967.1 - 0.00099 18.4 0.1 0.0021 17.3 0.1 1.5 1 1 0 1 1 1 1 Phosphate-selective porin O and P AhpC-TSA PF00578.21 EKE36967.1 - 0.08 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family NPL PF17800.1 EKE36968.1 - 8.2e-13 48.8 0.2 8.2e-13 48.8 0.2 1.6 2 0 0 2 2 2 1 Nucleoplasmin-like domain Ferric_reduct PF01794.19 EKE36969.1 - 4.9e-07 29.9 8.3 2e-06 28.0 8.3 2.0 1 1 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EKE36969.1 - 8.5e-05 22.6 0.2 0.0015 18.6 0.3 2.4 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_6 PF08030.12 EKE36969.1 - 0.00012 22.2 0.0 0.0031 17.6 0.0 2.3 1 1 1 2 2 2 1 Ferric reductase NAD binding domain Acetate_kinase PF00871.17 EKE36970.1 - 1.7e-93 313.4 0.4 1.9e-93 313.2 0.4 1.0 1 0 0 1 1 1 1 Acetokinase family Glyco_hydro_2_N PF02837.18 EKE36971.1 - 8.4e-06 25.8 1.1 2.7e-05 24.1 1.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 EKE36971.1 - 1.2e-05 25.9 0.0 2.8e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_C PF02836.17 EKE36971.1 - 0.00026 20.2 0.0 0.00044 19.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain WD40 PF00400.32 EKE36972.1 - 2.3e-11 44.0 7.8 9.7e-05 23.1 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat F-box PF00646.33 EKE36972.1 - 0.055 13.4 0.1 0.18 11.8 0.1 1.9 1 0 0 1 1 1 0 F-box domain Synaptobrevin PF00957.21 EKE36973.1 - 1.7e-28 98.2 0.1 2.8e-28 97.5 0.1 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EKE36973.1 - 2.7e-10 40.1 0.1 4.9e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain AAA_8 PF12780.7 EKE36973.1 - 0.0039 16.5 1.0 0.0055 16.1 1.0 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 CUE PF02845.16 EKE36974.1 - 1.2e-05 24.9 0.2 2.4e-05 23.9 0.2 1.5 1 0 0 1 1 1 1 CUE domain DUF4023 PF13215.6 EKE36974.1 - 1.4 9.0 6.9 0.81 9.7 4.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4023) Rad60-SLD PF11976.8 EKE36975.1 - 1e-20 73.3 0.1 1.3e-20 73.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EKE36975.1 - 1.6e-10 40.6 0.1 2e-10 40.3 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Vasohibin PF14822.6 EKE36975.1 - 0.032 13.5 0.2 0.037 13.2 0.2 1.1 1 0 0 1 1 1 0 Vasohibin TUG-UBL1 PF11470.8 EKE36975.1 - 0.079 13.2 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 TUG ubiquitin-like domain Methyltransf_28 PF02636.17 EKE36976.1 - 0.0061 16.2 0.7 0.008 15.8 0.7 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase CbiA PF01656.23 EKE36976.1 - 0.021 14.9 0.1 0.025 14.6 0.1 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain NigD_C PF17415.2 EKE36976.1 - 0.072 13.2 1.6 0.12 12.4 0.9 1.8 1 1 1 2 2 2 0 NigD-like C-terminal beta sandwich domain Lipase_GDSL_2 PF13472.6 EKE36977.1 - 4.1e-06 27.3 0.2 9.7e-06 26.1 0.2 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EKE36977.1 - 0.00084 19.4 3.8 0.0048 16.9 3.8 2.2 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase CE2_N PF17996.1 EKE36977.1 - 0.022 14.7 0.1 0.045 13.7 0.1 1.5 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal SAC3_GANP PF03399.16 EKE36978.1 - 3.1e-25 89.2 1.8 3.9e-25 88.8 1.8 1.1 1 0 0 1 1 1 1 SAC3/GANP family DNAJ_related PF12339.8 EKE36979.1 - 0.021 15.0 0.1 0.078 13.2 0.0 2.0 2 0 0 2 2 2 0 DNA-J related protein CheR PF01739.18 EKE36979.1 - 0.15 11.6 1.1 0.28 10.6 0.7 1.7 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain Sp38 PF07354.12 EKE36982.1 - 0.97 8.8 6.1 2.6 7.5 6.1 1.7 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Acetyltransf_1 PF00583.25 EKE36983.1 - 1.2e-15 57.8 0.0 1.6e-15 57.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EKE36983.1 - 3.9e-09 36.4 0.0 5.3e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EKE36983.1 - 1.4e-08 35.0 0.0 2.1e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EKE36983.1 - 1.8e-08 34.4 0.0 2e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EKE36983.1 - 2.9e-06 28.0 0.0 3.7e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EKE36983.1 - 0.0001 22.0 0.0 0.00016 21.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EKE36983.1 - 0.00022 20.9 0.0 0.00029 20.5 0.0 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_9 PF13527.7 EKE36983.1 - 0.0041 17.2 0.0 0.02 15.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EKE36983.1 - 0.017 15.3 0.3 0.019 15.1 0.3 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DAGK_prokar PF01219.19 EKE36983.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic diacylglycerol kinase DUF600 PF04634.12 EKE36984.1 - 0.025 14.6 2.6 1 9.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF600 UMP1 PF05348.11 EKE36986.1 - 1.3e-05 25.4 0.0 1.9e-05 24.8 0.0 1.3 1 1 0 1 1 1 1 Proteasome maturation factor UMP1 HECW_N PF16562.5 EKE36988.1 - 0.00013 21.7 0.1 0.00024 20.9 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 SKICH PF17751.1 EKE36988.1 - 0.0009 19.8 2.2 0.001 19.6 0.6 1.9 2 1 0 2 2 2 1 SKICH domain NUP214 PF16755.5 EKE36989.1 - 0.00028 20.3 3.7 0.00028 20.3 3.7 1.6 1 1 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 LRR_8 PF13855.6 EKE36989.1 - 0.028 14.2 0.6 3.4 7.5 0.5 3.0 2 0 0 2 2 2 0 Leucine rich repeat Pkinase PF00069.25 EKE36990.1 - 6.4e-56 189.6 0.4 5.6e-54 183.3 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE36990.1 - 1.6e-33 116.1 0.1 2.6e-32 112.1 0.0 2.4 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE36990.1 - 2e-07 30.2 0.0 3e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKE36990.1 - 0.042 13.8 0.0 0.076 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EKE36990.1 - 0.1 11.9 0.1 0.25 10.6 0.1 1.7 1 1 0 1 1 1 0 Kinase-like Phage_holin_3_6 PF07332.11 EKE36993.1 - 0.16 12.0 14.3 0.66 10.0 1.7 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF805 PF05656.14 EKE36993.1 - 3.4 8.1 14.1 0.32 11.4 3.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF805) DUF1461 PF07314.11 EKE36993.1 - 6.8 6.5 18.0 0.17 11.8 8.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1461) PRCC PF10253.9 EKE36994.1 - 1e-05 26.4 8.5 1.2e-05 26.2 8.5 1.1 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting Pkinase_Tyr PF07714.17 EKE36995.1 - 3.9e-60 203.3 0.0 5.6e-60 202.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE36995.1 - 9.5e-52 176.0 0.0 1.5e-51 175.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.24 EKE36995.1 - 3.7e-06 26.9 11.0 0.00045 20.2 1.6 3.4 4 0 0 4 4 4 2 IPT/TIG domain Haspin_kinase PF12330.8 EKE36995.1 - 3.3e-05 23.0 0.5 7.3e-05 21.9 0.5 1.5 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EKE36995.1 - 0.0011 19.0 0.0 0.75 9.7 0.0 2.1 1 1 0 2 2 2 2 Phosphotransferase enzyme family Shisa PF13908.6 EKE36995.1 - 0.031 14.5 0.3 0.055 13.7 0.3 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TIG_plexin PF17960.1 EKE36995.1 - 0.048 13.7 0.0 0.17 11.9 0.0 2.0 1 0 0 1 1 1 0 TIG domain DUF5527 PF17665.1 EKE36995.1 - 0.16 11.5 1.8 0.36 10.3 1.8 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Baculo_11_kDa PF06143.11 EKE36995.1 - 0.58 9.8 3.8 1.7 8.3 3.8 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family FeoB_associated PF12669.7 EKE36995.1 - 4 7.9 6.8 8.9 6.8 6.8 1.6 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Tweety PF04906.13 EKE36996.1 - 0.00059 18.6 16.0 0.0082 14.9 13.0 3.0 2 1 0 2 2 2 1 Tweety EI24 PF07264.11 EKE36996.1 - 0.0021 18.3 1.3 0.0021 18.3 1.3 2.2 2 1 1 3 3 3 1 Etoposide-induced protein 2.4 (EI24) CAMP_factor PF07373.11 EKE36996.1 - 0.0046 16.6 0.3 0.097 12.3 0.0 2.3 2 0 0 2 2 2 1 CAMP factor (Cfa) Wzy_C PF04932.15 EKE36996.1 - 0.074 12.7 1.1 0.5 10.0 0.2 2.4 2 0 0 2 2 2 0 O-Antigen ligase Inositol_P PF00459.25 EKE36997.1 - 4.6e-35 121.5 0.0 8.6e-35 120.6 0.0 1.4 1 1 0 1 1 1 1 Inositol monophosphatase family DUF3970 PF13113.6 EKE36997.1 - 0.11 12.8 0.1 1.5 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) PMM PF03332.13 EKE36998.1 - 1.4e-82 276.8 4.2 1.7e-82 276.5 4.2 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EKE36998.1 - 3.4e-09 36.8 1.0 1.4e-08 34.8 1.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKE36998.1 - 0.00015 21.4 0.0 0.052 13.1 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EKE36998.1 - 0.032 14.5 0.0 0.08 13.2 0.0 1.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase PNK3P PF08645.11 EKE36998.1 - 0.034 13.8 0.1 0.67 9.6 0.0 2.7 3 0 0 3 3 3 0 Polynucleotide kinase 3 phosphatase HAD_2 PF13419.6 EKE36998.1 - 0.038 14.1 0.7 0.27 11.3 0.1 2.4 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase RdRP PF05183.12 EKE36999.1 - 1.7e-06 27.0 0.0 5e-06 25.4 0.0 1.7 1 1 0 1 1 1 1 RNA dependent RNA polymerase MAF_flag10 PF01973.18 EKE36999.1 - 0.028 14.1 0.6 0.13 11.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF115 Acetyltransf_11 PF13720.6 EKE36999.1 - 0.22 12.0 3.1 1.4 9.4 0.0 3.2 3 0 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DPBB_1 PF03330.18 EKE37000.1 - 5.5e-05 23.4 0.2 0.00041 20.6 0.2 2.4 1 1 0 1 1 1 1 Lytic transglycolase DUF43 PF01861.16 EKE37000.1 - 0.11 11.7 0.4 0.19 10.9 0.4 1.3 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain DTW PF03942.15 EKE37003.1 - 1.3e-18 67.4 0.1 2e-18 66.8 0.1 1.3 1 0 0 1 1 1 1 DTW domain zf-B_box PF00643.24 EKE37003.1 - 0.055 13.6 2.2 0.14 12.4 2.2 1.7 1 0 0 1 1 1 0 B-box zinc finger CS PF04969.16 EKE37004.1 - 1.9e-15 57.7 1.9 3.2e-15 56.9 1.9 1.4 1 0 0 1 1 1 1 CS domain UQ_con PF00179.26 EKE37005.1 - 5e-49 165.6 0.0 5.6e-49 165.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKE37005.1 - 0.0023 17.6 0.0 0.003 17.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B ANAPC4_WD40 PF12894.7 EKE37006.1 - 6.3e-09 36.0 0.2 0.0014 18.9 0.0 4.3 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EKE37006.1 - 1.4e-06 28.9 3.1 0.24 12.3 0.0 5.9 6 0 0 6 6 6 2 WD domain, G-beta repeat Pkinase PF00069.25 EKE37007.1 - 6.1e-69 232.3 0.5 7.4e-69 232.0 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37007.1 - 4.6e-37 127.7 0.0 5.8e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE37007.1 - 4.9e-07 29.4 0.0 6.2e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FHA PF00498.26 EKE37007.1 - 0.0031 17.8 1.0 0.0074 16.6 0.3 2.1 2 0 0 2 2 2 1 FHA domain RIO1 PF01163.22 EKE37007.1 - 0.0044 16.7 1.1 0.0098 15.5 1.1 1.5 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EKE37007.1 - 0.051 12.9 0.2 0.083 12.2 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L38e PF01781.18 EKE37009.1 - 4.3e-23 81.2 2.9 5.2e-23 80.9 2.9 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family SNF2_N PF00176.23 EKE37010.1 - 1e-61 208.6 0.4 1.8e-61 207.8 0.4 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE37010.1 - 2.7e-19 69.6 0.0 2.2e-18 66.6 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EKE37010.1 - 0.00017 20.9 0.1 0.00017 20.9 0.1 2.1 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase HEAT_2 PF13646.6 EKE37010.1 - 0.00043 20.6 0.1 0.19 12.1 0.0 4.1 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 EKE37010.1 - 0.001 19.1 0.3 8.2 7.0 0.0 5.4 6 0 0 6 6 6 1 HEAT repeat XLF PF09302.11 EKE37010.1 - 0.055 13.6 1.1 2.4 8.3 0.2 3.4 3 0 0 3 3 3 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF4484 PF14831.6 EKE37010.1 - 0.61 10.1 2.0 0.65 10.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) TLD PF07534.16 EKE37011.1 - 0.00017 21.9 3.7 0.00034 20.8 3.7 1.6 1 1 0 1 1 1 1 TLD TLD PF07534.16 EKE37012.1 - 0.00042 20.5 0.7 0.0012 19.1 0.1 2.0 2 1 0 2 2 2 1 TLD MRP-S32 PF10210.9 EKE37012.1 - 0.14 12.7 0.8 0.35 11.4 0.1 2.0 2 1 0 2 2 2 0 Mitochondrial 28S ribosomal protein S32 EZH2_WD-Binding PF11616.8 EKE37012.1 - 5.9 7.1 6.5 5.6 7.1 2.5 2.3 2 0 0 2 2 2 0 WD repeat binding protein EZH2 DUF5074 PF16819.5 EKE37013.1 - 0.026 14.6 0.0 1.7 8.7 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5074) ANAPC4_WD40 PF12894.7 EKE37013.1 - 0.065 13.5 0.1 26 5.2 0.0 3.9 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Gtr1_RagA PF04670.12 EKE37014.1 - 3.8e-79 265.3 2.0 4.9e-79 265.0 2.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EKE37014.1 - 1.2e-09 37.8 0.1 1.8e-09 37.3 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EKE37014.1 - 1.4e-09 37.8 0.4 3.3e-09 36.5 0.4 1.7 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37014.1 - 7.9e-09 35.8 0.1 1.8e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EKE37014.1 - 5.5e-08 32.9 0.0 1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE37014.1 - 4.7e-05 22.9 0.1 7.7e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EKE37014.1 - 0.0079 15.9 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EKE37014.1 - 0.01 16.4 0.1 0.025 15.1 0.0 1.6 1 1 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.27 EKE37014.1 - 0.01 15.4 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF815 PF05673.13 EKE37014.1 - 0.02 14.1 0.9 0.34 10.0 0.9 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF815) FBA_3 PF08268.12 EKE37014.1 - 0.064 13.2 2.7 0.7 9.8 1.1 2.6 2 1 0 2 2 2 0 F-box associated domain G-alpha PF00503.20 EKE37014.1 - 0.14 11.3 10.8 0.46 9.6 4.0 3.0 1 1 1 2 2 2 0 G-protein alpha subunit RsgA_GTPase PF03193.16 EKE37014.1 - 0.19 11.6 0.2 1.6 8.6 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase FNIP PF05725.12 EKE37015.1 - 0.017 15.3 15.0 2.8 8.2 0.0 5.6 5 1 0 5 5 5 0 FNIP Repeat bZIP_Maf PF03131.17 EKE37016.1 - 7.4e-19 68.1 9.5 7.4e-19 68.1 9.5 2.4 3 0 0 3 3 3 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EKE37016.1 - 3.9e-05 23.7 13.4 3.9e-05 23.7 13.4 2.6 2 1 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EKE37016.1 - 0.0001 22.3 8.1 0.0001 22.3 8.1 2.6 3 1 0 4 4 3 1 Basic region leucine zipper Peptidase_M61 PF05299.12 EKE37016.1 - 0.093 13.1 0.6 14 6.1 0.0 2.2 1 1 1 2 2 2 0 M61 glycyl aminopeptidase DUF2810 PF10928.8 EKE37016.1 - 0.12 12.4 0.5 0.3 11.1 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2810) Topoisom_I_N PF02919.15 EKE37016.1 - 0.14 11.6 2.7 0.21 11.1 2.7 1.2 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment NPV_P10 PF05531.12 EKE37016.1 - 0.35 11.4 3.0 0.35 11.4 0.6 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Nrap_D6 PF17407.2 EKE37016.1 - 0.45 10.7 5.0 2 8.6 2.1 2.3 1 1 1 2 2 2 0 Nrap protein domain 6 Tsg PF04668.12 EKE37016.1 - 0.49 11.1 2.8 0.76 10.5 2.8 1.3 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region DIRP PF06584.13 EKE37016.1 - 0.66 10.2 11.8 1.8 8.8 0.6 2.4 1 1 1 2 2 2 0 DIRP V_ATPase_I PF01496.19 EKE37016.1 - 3.7 5.3 7.4 4.4 5.1 7.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Clat_adaptor_s PF01217.20 EKE37017.1 - 1.9e-48 164.0 2.8 2.1e-48 163.9 2.8 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TLD PF07534.16 EKE37018.1 - 0.0026 18.0 1.2 0.0026 18.0 1.2 2.0 2 0 0 2 2 2 1 TLD Allexi_40kDa PF05549.11 EKE37018.1 - 0.68 9.4 6.2 0.26 10.8 3.9 1.5 2 0 0 2 2 2 0 Allexivirus 40kDa protein TEX12 PF15219.6 EKE37018.1 - 0.94 9.8 8.5 1.3 9.4 0.4 3.1 2 1 0 3 3 3 0 Testis-expressed 12 Presenilin PF01080.17 EKE37018.1 - 5.4 5.7 5.4 7.1 5.3 5.4 1.1 1 0 0 1 1 1 0 Presenilin CNOT1_TTP_bind PF16417.5 EKE37019.1 - 6.5e-41 139.6 1.0 4.5e-40 136.8 0.0 2.9 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_CAF1_bind PF16415.5 EKE37019.1 - 7.4e-20 71.3 2.3 7.4e-20 71.3 2.3 3.5 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Not1 PF04054.15 EKE37019.1 - 1.2e-19 70.5 18.5 1.2e-16 60.6 7.0 3.2 3 0 0 3 3 3 2 CCR4-Not complex component, Not1 DUF3819 PF12842.7 EKE37019.1 - 1.2e-08 35.0 2.4 1.2e-08 35.0 2.4 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 EKE37019.1 - 3.2e-07 30.5 0.1 2.3e-06 27.7 0.1 2.6 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat NLRC4_HD PF17889.1 EKE37019.1 - 2 8.8 10.3 0.77 10.1 0.9 4.2 3 0 0 3 3 3 0 NLRC4 helical domain Ras PF00071.22 EKE37020.1 - 1.6e-51 174.1 1.3 1.9e-51 173.9 1.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37020.1 - 1.6e-27 96.1 1.0 1.8e-27 95.9 0.1 1.5 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37020.1 - 1.5e-11 44.1 0.1 1.8e-11 43.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE37020.1 - 3.5e-10 39.7 0.5 1.2e-08 34.8 0.5 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE37020.1 - 7e-07 29.3 0.0 1.2e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE37020.1 - 4.5e-06 26.7 0.4 0.039 13.9 0.1 3.0 1 1 2 3 3 3 2 RsgA GTPase AAA_28 PF13521.6 EKE37020.1 - 6e-05 23.3 0.0 0.00014 22.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EKE37020.1 - 9.7e-05 21.9 0.0 0.00022 20.7 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EKE37020.1 - 0.0015 18.9 0.0 0.027 14.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EKE37020.1 - 0.0021 17.9 0.7 0.023 14.5 0.1 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EKE37020.1 - 0.0068 16.2 0.0 0.24 11.2 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 EKE37020.1 - 0.0086 15.4 0.5 0.012 14.9 0.0 1.5 2 0 0 2 2 2 1 Septin ATPase_2 PF01637.18 EKE37020.1 - 0.02 14.8 0.1 0.031 14.2 0.0 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EKE37020.1 - 0.05 13.3 0.0 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EKE37020.1 - 0.053 13.6 0.0 0.098 12.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EKE37020.1 - 0.066 13.6 0.0 0.15 12.5 0.0 1.6 1 1 1 2 2 2 0 AAA ATPase domain FeoB_N PF02421.18 EKE37020.1 - 0.067 12.7 0.2 0.62 9.6 0.0 2.3 2 1 0 2 2 2 0 Ferrous iron transport protein B AAA_18 PF13238.6 EKE37020.1 - 0.08 13.5 0.2 0.12 12.9 0.2 1.4 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EKE37020.1 - 0.085 13.3 0.0 0.47 10.9 0.0 2.3 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EKE37020.1 - 0.086 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DnaB_C PF03796.15 EKE37020.1 - 0.091 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_33 PF13671.6 EKE37020.1 - 0.099 12.8 0.0 0.22 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain Glyco_transf_8 PF01501.20 EKE37021.1 - 0.031 13.8 0.4 0.031 13.8 0.4 1.6 2 0 0 2 2 2 0 Glycosyl transferase family 8 LRR_5 PF13306.6 EKE37022.1 - 1e-91 303.5 35.4 6.8e-31 106.9 6.4 4.3 3 1 1 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE37022.1 - 1.1e-20 73.1 0.0 0.00011 21.9 0.0 7.2 3 2 5 8 8 8 6 Leucine rich repeat FNIP PF05725.12 EKE37022.1 - 1.1 9.5 0.0 1.1 9.5 0.0 6.9 6 1 2 8 8 8 0 FNIP Repeat Stealth_CR2 PF11380.8 EKE37024.1 - 1.7e-40 137.5 0.9 3.2e-40 136.6 0.9 1.5 1 0 0 1 1 1 1 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 EKE37024.1 - 1.6e-13 50.3 0.0 2.8e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR4 PF17103.5 EKE37024.1 - 2.5e-09 36.9 0.1 6.6e-09 35.5 0.0 1.8 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 Stealth_CR1 PF17101.5 EKE37024.1 - 7.1e-09 35.2 0.9 1.2e-08 34.5 0.0 1.8 2 0 0 2 2 2 1 Stealth protein CR1, conserved region 1 Stealth_CR2 PF11380.8 EKE37025.1 - 1.8e-38 131.0 2.0 1.8e-38 131.0 2.0 1.8 2 0 0 2 2 2 1 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 EKE37025.1 - 4.6e-15 55.2 0.5 4.6e-15 55.2 0.5 1.7 2 0 0 2 2 2 1 Stealth protein CR3, conserved region 3 Stealth_CR4 PF17103.5 EKE37025.1 - 1.4e-08 34.4 0.8 1.4e-08 34.4 0.8 2.0 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 Stealth_CR1 PF17101.5 EKE37025.1 - 3.1e-07 30.0 0.1 1.1e-06 28.3 0.1 1.9 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 BRCT PF00533.26 EKE37025.1 - 0.067 13.6 0.0 5 7.6 0.0 2.6 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain APS_kinase PF01583.20 EKE37026.1 - 8.4e-60 201.2 0.0 1.3e-59 200.6 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 EKE37026.1 - 4.6e-18 65.4 0.0 9.3e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 EKE37026.1 - 5.5e-07 29.8 0.0 9e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EKE37026.1 - 0.016 14.4 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EKE37026.1 - 0.024 15.0 0.0 0.041 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EKE37026.1 - 0.041 13.6 0.0 0.093 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EKE37026.1 - 0.063 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 EKE37026.1 - 0.074 13.0 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ATPase_2 PF01637.18 EKE37026.1 - 0.082 12.8 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EKE37026.1 - 0.097 13.0 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 EKE37026.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 EKE37026.1 - 0.16 12.5 0.0 0.42 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EKE37026.1 - 0.18 10.8 0.1 0.37 9.8 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein DHR-2 PF06920.13 EKE37027.1 - 5.4e-17 61.6 25.8 3.1e-14 52.5 2.1 4.2 3 1 0 3 3 3 2 Dock homology region 2 EF-hand_7 PF13499.6 EKE37027.1 - 0.0052 17.2 5.4 0.38 11.2 0.2 3.7 2 0 0 2 2 2 2 EF-hand domain pair OS-D PF03392.13 EKE37027.1 - 0.065 13.3 2.5 0.4 10.8 2.5 2.4 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D DUF5388 PF17363.2 EKE37027.1 - 0.61 10.3 4.5 0.9 9.8 0.4 3.5 3 0 0 3 3 3 0 Family of unknown function (DUF5388) EF-hand_6 PF13405.6 EKE37027.1 - 0.99 9.5 9.4 0.98 9.5 0.5 3.5 3 0 0 3 3 3 0 EF-hand domain Syntaxin-18_N PF10496.9 EKE37028.1 - 1.2 9.5 9.0 0.11 12.8 3.4 1.8 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus DUF4337 PF14235.6 EKE37028.1 - 6.4 6.9 8.8 2.2 8.4 3.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Nrap_D4 PF17405.2 EKE37029.1 - 1.5e-21 76.8 0.0 2.5e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D3 PF17404.2 EKE37029.1 - 4.2e-16 59.4 0.0 6.7e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D5 PF17406.2 EKE37029.1 - 4.5e-09 36.3 0.1 1.9e-07 31.0 0.1 2.7 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D6 PF17407.2 EKE37029.1 - 1.9e-06 28.1 0.0 3.6e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 6 HTH_Tnp_1 PF01527.20 EKE37030.1 - 0.12 12.7 0.9 0.41 11.0 0.1 2.0 2 0 0 2 2 2 0 Transposase Flavodoxin_1 PF00258.25 EKE37031.1 - 6.8e-07 29.6 0.0 1e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin Lactamase_B PF00753.27 EKE37031.1 - 1.9e-06 28.0 0.1 3.4e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF1256 PF06866.11 EKE37031.1 - 0.015 14.7 2.9 0.42 10.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1256) Peripla_BP_5 PF13433.6 EKE37031.1 - 0.024 13.6 0.5 0.12 11.3 0.1 2.0 2 0 0 2 2 2 0 Periplasmic binding protein domain FMN_red PF03358.15 EKE37031.1 - 0.026 14.2 0.0 0.54 10.0 0.0 2.3 1 1 0 1 1 1 0 NADPH-dependent FMN reductase Lactamase_B_2 PF12706.7 EKE37031.1 - 0.031 13.8 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Sulfotransfer_3 PF13469.6 EKE37031.1 - 0.031 14.6 0.0 0.099 13.0 0.0 1.9 1 1 0 1 1 1 0 Sulfotransferase family Ribosomal_L23eN PF03939.13 EKE37032.1 - 0.27 11.5 2.1 0.8 10.0 2.1 1.8 1 0 0 1 1 1 0 Ribosomal protein L23, N-terminal domain Methyltransf_16 PF10294.9 EKE37033.1 - 3.8e-16 59.3 0.2 5.1e-16 58.9 0.2 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_31 PF13847.6 EKE37033.1 - 4.4e-05 23.3 0.2 6.7e-05 22.7 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EKE37033.1 - 5.5e-05 23.8 0.1 0.00012 22.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKE37033.1 - 0.00024 21.0 0.0 0.00034 20.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE37033.1 - 0.00076 20.1 0.0 0.0012 19.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKE37033.1 - 0.0021 18.6 0.0 0.0032 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EKE37033.1 - 0.0054 16.5 0.0 0.0074 16.1 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein NNMT_PNMT_TEMT PF01234.17 EKE37033.1 - 0.05 12.8 0.0 0.081 12.1 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family PCMT PF01135.19 EKE37033.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ssu72 PF04722.13 EKE37035.1 - 3.5e-53 180.0 0.7 3.9e-53 179.9 0.7 1.0 1 0 0 1 1 1 1 Ssu72-like protein AMP-binding PF00501.28 EKE37036.1 - 9.5e-87 291.3 0.0 1.2e-86 290.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme MIG-14_Wnt-bd PF06664.12 EKE37037.1 - 1.1e-65 221.8 42.1 4.8e-65 219.7 39.5 2.0 2 0 0 2 2 2 2 Wnt-binding factor required for Wnt secretion Prenyltrans PF00432.21 EKE37038.1 - 9.8e-65 214.0 10.2 9.6e-14 50.8 0.1 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EKE37038.1 - 0.00077 18.6 0.0 0.39 9.8 0.0 3.5 1 1 4 5 5 5 3 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 EKE37038.1 - 0.0073 15.4 0.0 0.094 11.8 0.0 2.3 1 1 2 3 3 3 1 Squalene-hopene cyclase C-terminal domain RhoGAP PF00620.27 EKE37039.1 - 2.4e-10 40.4 0.6 1e-09 38.4 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain NCD3G PF07562.14 EKE37040.1 - 0.0083 16.1 1.1 0.0083 16.1 1.1 6.2 4 1 3 7 7 7 4 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.13 EKE37040.1 - 0.044 13.6 44.5 0.13 12.0 2.9 6.0 1 1 3 4 4 4 0 Putative ephrin-receptor like ubiquitin PF00240.23 EKE37042.1 - 4.7e-11 42.3 0.1 8e-11 41.5 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKE37042.1 - 0.0018 18.1 0.0 0.0042 16.9 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Hfx_Cass5 PF18287.1 EKE37043.1 - 0.03 14.5 0.0 8.2 6.7 0.0 3.4 3 0 0 3 3 3 0 Integron Cassette Protein Hfx_Cass5 T4-Gluco-transf PF09198.10 EKE37043.1 - 0.19 11.4 3.5 2.1 8.0 0.1 3.7 3 1 0 3 3 3 0 Bacteriophage T4 beta-glucosyltransferase RasGAP PF00616.19 EKE37045.1 - 1.8e-07 31.1 5.3 0.00036 20.3 0.2 2.7 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase Smac_DIABLO PF09057.10 EKE37045.1 - 0.045 13.1 0.0 0.095 12.0 0.0 1.6 1 1 0 1 1 1 0 Second Mitochondria-derived Activator of Caspases bZIP_1 PF00170.21 EKE37045.1 - 0.066 13.3 1.0 0.2 11.8 1.0 1.8 1 0 0 1 1 1 0 bZIP transcription factor Shugoshin_N PF07558.11 EKE37045.1 - 0.088 12.7 5.0 0.24 11.3 5.0 1.8 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region HALZ PF02183.18 EKE37045.1 - 0.1 12.9 3.0 0.36 11.1 2.8 2.0 1 1 1 2 2 2 0 Homeobox associated leucine zipper RasGAP PF00616.19 EKE37046.1 - 6.6e-30 104.4 4.2 6.6e-30 104.4 4.2 3.4 4 1 0 4 4 4 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EKE37046.1 - 9.5e-20 71.1 7.9 9.5e-20 71.1 7.9 2.8 2 0 0 2 2 2 1 RasGAP C-terminus ZnuA PF01297.17 EKE37046.1 - 0.062 12.7 0.5 0.69 9.3 1.0 2.2 2 1 0 2 2 2 0 Zinc-uptake complex component A periplasmic ZapD PF07072.11 EKE37046.1 - 0.64 9.7 8.8 0.024 14.4 1.9 2.2 2 1 0 2 2 2 0 Cell division protein Prominin PF05478.11 EKE37047.1 - 0.0051 14.8 5.1 0.0072 14.4 5.1 1.3 1 0 0 1 1 1 1 Prominin Med3 PF11593.8 EKE37047.1 - 0.0058 15.9 0.7 0.053 12.7 0.3 2.1 2 0 0 2 2 2 1 Mediator complex subunit 3 fungal Topo_C_assoc PF14370.6 EKE37047.1 - 0.01 15.7 0.1 0.048 13.6 0.1 2.2 1 0 0 1 1 1 0 C-terminal topoisomerase domain CmlA_N PF18456.1 EKE37047.1 - 0.034 13.4 0.3 0.069 12.4 0.3 1.5 1 0 0 1 1 1 0 Diiron non-heme beta-hydroxylase N-terminal domain UCH_N PF16674.5 EKE37047.1 - 0.043 13.8 2.3 2.2 8.3 0.2 2.7 2 0 0 2 2 2 0 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 FtsX_ECD PF18075.1 EKE37047.1 - 0.093 13.4 5.9 0.51 11.0 3.1 2.7 2 2 0 2 2 2 0 FtsX extracellular domain FTCD_C PF04961.12 EKE37047.1 - 0.11 12.2 6.9 0.25 11.1 4.9 2.1 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase DUF3584 PF12128.8 EKE37047.1 - 0.13 9.8 10.7 0.22 9.0 9.8 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Sec34 PF04136.15 EKE37047.1 - 0.18 11.7 5.9 2 8.3 1.0 3.0 1 1 3 4 4 4 0 Sec34-like family Syntaxin-6_N PF09177.11 EKE37047.1 - 0.25 11.9 4.0 0.29 11.7 1.0 2.4 1 1 0 2 2 2 0 Syntaxin 6, N-terminal YtxH PF12732.7 EKE37047.1 - 0.79 10.3 15.0 1.5 9.4 3.1 4.1 1 1 1 2 2 2 0 YtxH-like protein DUF4407 PF14362.6 EKE37047.1 - 7.6 5.8 6.9 7.3 5.9 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) HORMA PF02301.18 EKE37048.1 - 0.018 14.7 2.0 0.02 14.5 1.5 1.3 1 1 0 1 1 1 0 HORMA domain RhoGEF PF00621.20 EKE37049.1 - 3.6e-35 121.9 8.2 3.6e-35 121.9 8.2 2.6 3 1 0 3 3 3 1 RhoGEF domain ArfGap PF01412.18 EKE37049.1 - 2.6e-12 46.8 0.2 1.1e-11 44.9 0.2 2.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 EKE37049.1 - 8e-11 42.4 0.4 3.1e-05 24.4 0.1 3.1 2 0 0 2 2 2 2 PH domain PH_6 PF15406.6 EKE37049.1 - 0.03 14.6 0.1 11 6.3 0.0 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain DUF3973 PF13119.6 EKE37049.1 - 0.51 10.5 4.0 1.5 8.9 2.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3973) LCAT PF02450.15 EKE37051.1 - 7.4e-38 130.7 1.6 1.6e-35 123.0 0.1 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 EKE37051.1 - 6.8e-06 26.0 0.0 5.6e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EKE37051.1 - 0.0014 19.3 0.0 0.0019 18.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EKE37051.1 - 0.0034 16.9 0.0 0.0057 16.2 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EKE37051.1 - 0.056 12.7 0.0 0.081 12.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF900 PF05990.12 EKE37051.1 - 0.16 11.5 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) HSP70 PF00012.20 EKE37053.1 - 1e-08 33.9 16.4 3.4e-06 25.6 0.5 3.5 3 1 1 4 4 4 3 Hsp70 protein TRAPP PF04051.16 EKE37053.1 - 0.01 15.6 0.6 0.65 9.7 0.1 2.6 2 1 0 2 2 2 0 Transport protein particle (TRAPP) component RuvC PF02075.17 EKE37053.1 - 0.026 14.4 0.1 0.33 10.8 0.1 2.4 2 0 0 2 2 2 0 Crossover junction endodeoxyribonuclease RuvC MoCF_biosynth PF00994.24 EKE37053.1 - 0.055 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Probable molybdopterin binding domain UPF0542 PF15086.6 EKE37053.1 - 0.52 10.3 3.6 1.4 8.9 0.6 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 SLS PF14611.6 EKE37054.1 - 0.0096 15.8 0.1 0.022 14.6 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator zf-Sec23_Sec24 PF04810.15 EKE37054.1 - 0.11 12.6 1.8 0.41 10.7 0.4 2.7 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger RPEL PF02755.15 EKE37054.1 - 0.15 11.8 0.1 0.4 10.4 0.1 1.8 1 0 0 1 1 1 0 RPEL repeat RhoGAP PF00620.27 EKE37055.1 - 1.8e-13 50.6 0.0 2.8e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain DHR-2 PF06920.13 EKE37056.1 - 1.4e-36 126.2 4.4 1.4e-36 126.2 4.4 3.3 2 2 0 2 2 2 1 Dock homology region 2 CCDC74_C PF14917.6 EKE37056.1 - 0.029 14.9 0.3 90 3.6 0.1 4.7 4 0 0 4 4 4 0 Coiled coil protein 74, C terminal SesA PF17107.5 EKE37056.1 - 0.15 12.2 4.4 0.19 11.9 0.2 3.4 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RhoGEF PF00621.20 EKE37057.1 - 4.9e-34 118.2 0.5 1e-33 117.1 0.5 1.6 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 EKE37057.1 - 1.3e-06 28.4 9.4 1.3e-06 28.4 9.4 2.2 2 0 0 2 2 2 1 FYVE zinc finger PH PF00169.29 EKE37057.1 - 0.057 13.9 0.3 0.057 13.9 0.3 2.8 2 1 0 2 2 2 0 PH domain PH_11 PF15413.6 EKE37057.1 - 0.1 13.1 0.5 0.45 11.0 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain FYVE_2 PF02318.16 EKE37057.1 - 2.5 8.4 10.3 0.21 11.8 4.8 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger UQ_con PF00179.26 EKE37059.1 - 2.5e-43 147.1 0.1 3.1e-43 146.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKE37059.1 - 0.0013 18.4 0.0 0.0027 17.4 0.0 1.7 1 1 0 1 1 1 1 Prokaryotic E2 family B VCBS PF13517.6 EKE37060.1 - 4.1e-07 30.5 0.3 0.06 13.9 0.0 4.7 4 0 0 4 4 4 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PQQ_2 PF13360.6 EKE37060.1 - 0.0063 16.1 0.0 4.9 6.7 0.0 3.3 2 1 1 3 3 3 2 PQQ-like domain FG-GAP PF01839.23 EKE37060.1 - 0.0093 16.1 0.2 0.0093 16.1 0.2 2.8 3 0 0 3 3 3 1 FG-GAP repeat TcdB_toxin_midN PF12256.8 EKE37060.1 - 0.12 11.7 0.1 5.1 6.4 0.0 2.2 2 0 0 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region Ras PF00071.22 EKE37061.1 - 2.5e-14 53.2 0.0 2.9e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37061.1 - 3.5e-10 40.1 0.0 4.8e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EKE37061.1 - 4.7e-07 29.9 0.0 0.0043 17.0 0.1 2.1 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 EKE37061.1 - 7.9e-06 25.4 0.0 1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE37061.1 - 0.00017 21.6 0.0 0.00045 20.3 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKE37061.1 - 0.011 15.3 0.0 0.046 13.3 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B ABC_tran PF00005.27 EKE37061.1 - 0.02 15.4 0.0 0.03 14.8 0.0 1.3 1 0 0 1 1 1 0 ABC transporter IIGP PF05049.13 EKE37061.1 - 0.029 13.4 0.0 0.042 12.9 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ATPase_2 PF01637.18 EKE37061.1 - 0.033 14.1 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF815 PF05673.13 EKE37061.1 - 0.056 12.6 0.0 0.069 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SMC_N PF02463.19 EKE37061.1 - 0.081 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.23 EKE37061.1 - 0.085 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Dynamin family Metallophos PF00149.28 EKE37062.1 - 1e-09 39.2 0.1 1.6e-09 38.6 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CCDC53 PF10152.9 EKE37062.1 - 0.087 13.2 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Pkinase_Tyr PF07714.17 EKE37063.1 - 5e-17 62.0 0.1 9.8e-17 61.1 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37063.1 - 6.2e-14 52.0 0.1 1.1e-13 51.2 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain VSP PF03302.13 EKE37063.1 - 0.0063 15.4 17.0 0.0063 15.4 17.0 7.8 1 1 4 5 5 5 3 Giardia variant-specific surface protein Motile_Sperm PF00635.26 EKE37063.1 - 0.07 13.0 0.3 0.15 11.9 0.3 1.5 1 0 0 1 1 1 0 MSP (Major sperm protein) domain DUF4330 PF14221.6 EKE37063.1 - 0.073 13.3 0.4 0.15 12.2 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) TMEM154 PF15102.6 EKE37063.1 - 0.098 12.6 0.6 0.28 11.1 0.2 1.9 2 0 0 2 2 2 0 TMEM154 protein family EphA2_TM PF14575.6 EKE37063.1 - 0.15 13.0 0.3 0.74 10.7 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Pkinase PF00069.25 EKE37065.1 - 3.3e-35 121.7 0.0 4.7e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37065.1 - 9.9e-19 67.6 0.0 1.5e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE37065.1 - 0.035 13.4 0.0 0.069 12.5 0.0 1.5 1 1 0 1 1 1 0 Kinase-like DUF4824 PF16106.5 EKE37066.1 - 0.035 13.4 2.0 0.044 13.0 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4824) THP2 PF09432.10 EKE37066.1 - 0.045 13.8 3.3 0.05 13.6 3.3 1.1 1 0 0 1 1 1 0 Tho complex subunit THP2 TPR_2 PF07719.17 EKE37067.1 - 1.7e-21 74.5 12.1 8.3e-05 22.4 0.1 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 EKE37067.1 - 4e-19 67.6 24.8 2.3e-05 24.0 0.0 7.8 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 EKE37067.1 - 1.2e-16 60.8 2.0 6.5e-07 29.6 0.0 5.2 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EKE37067.1 - 5.9e-10 38.5 0.7 0.0081 16.1 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKE37067.1 - 4.7e-09 35.7 15.3 0.032 14.4 0.0 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EKE37067.1 - 5.7e-08 33.3 0.0 5.2e-05 23.8 0.0 3.5 4 1 1 5 5 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EKE37067.1 - 1.7e-05 25.2 9.1 0.6 10.9 0.0 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EKE37067.1 - 1.7e-05 25.2 0.0 42 5.3 0.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EKE37067.1 - 2.1e-05 24.9 3.2 0.14 12.7 0.1 5.6 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 EKE37067.1 - 0.00045 19.8 6.6 0.7 9.6 0.1 5.8 6 0 0 6 6 6 1 TPR repeat TPR_10 PF13374.6 EKE37067.1 - 0.0043 16.9 0.6 8.9 6.3 0.0 5.5 7 0 0 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE37067.1 - 0.0095 16.1 14.6 0.92 9.8 2.9 5.1 4 2 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 EKE37067.1 - 0.012 15.0 0.1 0.044 13.2 0.0 1.9 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP Sel1 PF08238.12 EKE37067.1 - 0.034 14.9 0.1 1.5 9.6 0.0 2.6 2 0 0 2 2 2 0 Sel1 repeat TPR_3 PF07720.12 EKE37067.1 - 0.091 12.8 0.1 0.091 12.8 0.1 5.6 8 0 0 8 8 8 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EKE37067.1 - 0.15 11.6 5.4 4 7.0 0.0 3.9 4 0 0 4 4 4 0 SHNi-TPR MIT PF04212.18 EKE37067.1 - 0.45 10.6 10.8 12 6.1 0.0 5.3 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.12 EKE37068.1 - 2.2e-07 31.3 0.6 0.021 15.5 0.0 4.2 4 1 0 4 4 4 2 Sel1 repeat TPR_19 PF14559.6 EKE37068.1 - 0.0013 19.2 8.1 0.17 12.4 0.0 4.6 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKE37068.1 - 0.0025 17.9 13.9 0.037 14.2 0.1 5.7 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EKE37068.1 - 0.0033 17.4 0.7 23 5.4 0.0 4.7 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EKE37068.1 - 0.011 16.5 0.0 0.29 12.1 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EKE37068.1 - 0.011 16.3 1.8 0.21 12.3 0.1 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_15 PF13429.6 EKE37068.1 - 0.038 13.2 0.0 0.1 11.8 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Tai4 PF16695.5 EKE37068.1 - 0.038 14.5 0.3 0.15 12.6 0.1 2.2 2 0 0 2 2 2 0 Type VI secretion system (T6SS), amidase immunity protein TPR_1 PF00515.28 EKE37068.1 - 0.053 13.4 1.3 18 5.3 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Ferritin PF00210.24 EKE37068.1 - 0.058 13.3 0.3 0.058 13.3 0.3 2.1 2 0 0 2 2 2 0 Ferritin-like domain Cas9_a PF18470.1 EKE37068.1 - 0.15 11.6 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 Cas9 alpha-helical lobe domain Orf78 PF06024.12 EKE37069.1 - 0.001 19.4 0.3 0.0012 19.2 0.3 1.2 1 0 0 1 1 1 1 Orf78 (ac78) Stevor PF17410.2 EKE37069.1 - 0.01 15.4 0.1 0.01 15.4 0.1 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame TMEM154 PF15102.6 EKE37069.1 - 0.015 15.2 4.2 0.019 14.9 4.2 1.4 1 1 0 1 1 1 0 TMEM154 protein family DUF4736 PF15883.5 EKE37069.1 - 0.075 12.8 0.6 0.087 12.5 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) DUF1201 PF06716.11 EKE37069.1 - 0.91 9.6 7.7 1.5 8.9 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) Shisa PF13908.6 EKE37069.1 - 2.3 8.4 4.5 2.2 8.5 4.0 1.3 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF2897 PF11446.8 EKE37070.1 - 0.0012 18.6 0.2 0.003 17.4 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2897) Vma12 PF11712.8 EKE37070.1 - 0.013 15.6 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Zip PF02535.22 EKE37070.1 - 0.051 12.8 0.0 0.071 12.3 0.0 1.3 1 1 0 1 1 1 0 ZIP Zinc transporter Bacteriocin_IIc PF10439.9 EKE37070.1 - 8.5 6.6 10.5 11 6.2 10.5 1.2 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide MCM PF00493.23 EKE37071.1 - 3.1e-101 337.2 0.1 6.7e-101 336.1 0.1 1.6 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EKE37071.1 - 2.2e-33 114.8 3.7 2.6e-33 114.6 0.9 2.2 2 0 0 2 2 2 1 MCM OB domain MCM_lid PF17855.1 EKE37071.1 - 3.2e-28 98.0 0.5 8.8e-26 90.2 0.1 2.9 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 EKE37071.1 - 8.2e-13 48.8 0.0 3.9e-12 46.7 0.0 2.2 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EKE37071.1 - 2.1e-10 40.3 0.1 6.5e-08 32.2 0.0 2.7 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EKE37071.1 - 1.2e-07 31.9 0.0 2.5e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EKE37071.1 - 0.00013 21.8 0.0 0.015 15.2 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EKE37071.1 - 0.0014 18.4 0.0 0.0081 15.9 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 EKE37071.1 - 0.13 12.6 0.5 1.4 9.3 0.5 2.3 1 1 1 2 2 2 0 AAA ATPase domain Ras PF00071.22 EKE37072.1 - 3.8e-51 172.9 1.2 4.5e-51 172.7 1.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37072.1 - 1.8e-30 105.6 0.2 3.7e-30 104.6 0.2 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37072.1 - 4.6e-14 52.3 0.2 5.6e-14 52.0 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE37072.1 - 7.3e-07 28.9 2.4 0.00019 21.1 2.4 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE37072.1 - 4.4e-05 23.5 0.1 6.4e-05 23.0 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE37072.1 - 0.00019 20.9 0.2 0.00079 18.9 0.1 2.0 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE37072.1 - 0.00034 20.6 0.6 0.61 10.0 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EKE37072.1 - 0.004 17.4 0.1 0.34 11.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain Gtr1_RagA PF04670.12 EKE37072.1 - 0.0041 16.5 0.2 0.0052 16.2 0.2 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 EKE37072.1 - 0.026 14.3 1.8 0.1 12.3 1.8 2.1 1 1 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 EKE37072.1 - 0.034 13.8 0.4 0.087 12.5 0.4 1.8 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Torsin PF06309.11 EKE37072.1 - 0.048 13.8 0.0 0.094 12.8 0.0 1.5 1 0 0 1 1 1 0 Torsin AAA_16 PF13191.6 EKE37072.1 - 0.12 12.8 0.0 0.19 12.1 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain SF3A2 PF16835.5 EKE37074.1 - 2.1e-27 95.3 0.0 3.8e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EKE37074.1 - 1.3e-05 25.4 2.1 2.1e-05 24.8 1.3 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 EKE37074.1 - 0.033 14.1 0.0 0.055 13.4 0.0 1.4 1 1 0 1 1 1 0 Cactus-binding C-terminus of cactin protein Baculo_ODV-E27 PF05314.11 EKE37074.1 - 0.059 12.5 0.0 0.075 12.2 0.0 1.2 1 0 0 1 1 1 0 Baculovirus occlusion-derived virus envelope protein EC27 PH PF00169.29 EKE37076.1 - 3.4e-14 53.2 0.1 8.1e-14 52.0 0.1 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EKE37076.1 - 0.00014 22.0 0.1 0.00029 21.0 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EKE37076.1 - 0.004 17.5 4.0 0.031 14.7 4.0 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain HECT PF00632.25 EKE37076.1 - 0.12 11.8 0.1 0.36 10.3 0.0 1.7 2 0 0 2 2 2 0 HECT-domain (ubiquitin-transferase) FYVE PF01363.21 EKE37077.1 - 3.7e-18 65.4 9.2 6.5e-18 64.6 9.2 1.4 1 0 0 1 1 1 1 FYVE zinc finger Arrestin_C PF02752.22 EKE37077.1 - 2.8e-06 27.8 0.7 0.00088 19.7 0.1 2.7 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 EKE37077.1 - 0.0079 15.4 1.2 0.022 13.9 0.4 2.1 2 1 0 2 2 2 1 Rgp1 FYVE_2 PF02318.16 EKE37077.1 - 0.12 12.6 6.4 0.25 11.6 6.4 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger zf-RING_2 PF13639.6 EKE37077.1 - 5.8 7.3 11.3 17 5.8 11.3 1.8 1 1 0 1 1 1 0 Ring finger domain Smr PF01713.21 EKE37078.1 - 0.00084 19.7 0.3 0.00084 19.7 0.3 2.1 2 1 0 2 2 2 1 Smr domain Metal_resist PF13801.6 EKE37078.1 - 0.017 15.3 0.2 0.029 14.6 0.2 1.3 1 0 0 1 1 1 0 Heavy-metal resistance Taeniidae_ag PF05596.11 EKE37078.1 - 0.025 14.5 2.3 0.39 10.7 0.2 2.6 2 0 0 2 2 2 0 Taeniidae antigen TMEM210 PF15195.6 EKE37078.1 - 0.081 13.3 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 TMEM210 family DUF5024 PF16427.5 EKE37078.1 - 1.4 9.3 9.1 0.042 14.2 2.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF5024) Ras PF00071.22 EKE37079.1 - 6.3e-44 149.4 0.1 7.5e-44 149.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37079.1 - 1.4e-30 106.0 0.0 1.9e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37079.1 - 7.9e-17 61.2 0.0 1.1e-16 60.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.6 EKE37079.1 - 1.1e-05 25.7 0.0 2.3e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EKE37079.1 - 1.8e-05 24.3 0.0 2.6e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EKE37079.1 - 2.9e-05 24.1 0.0 4.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 EKE37079.1 - 5.5e-05 22.6 0.0 7.9e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Bacterial TniB protein Gtr1_RagA PF04670.12 EKE37079.1 - 5.6e-05 22.6 0.0 6.8e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE37079.1 - 0.00011 21.8 0.1 0.002 17.7 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE37079.1 - 0.0027 17.6 0.0 2.1 8.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Septin PF00735.18 EKE37079.1 - 0.0068 15.7 0.0 0.0095 15.2 0.0 1.2 1 0 0 1 1 1 1 Septin ATP_bind_1 PF03029.17 EKE37079.1 - 0.015 15.1 0.2 3.4 7.4 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 EKE37079.1 - 0.015 15.2 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EKE37079.1 - 0.019 14.7 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EKE37079.1 - 0.024 15.0 0.0 0.051 14.0 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EKE37079.1 - 0.035 13.6 0.0 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 EKE37079.1 - 0.057 13.2 0.1 0.4 10.4 0.0 2.1 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.26 EKE37079.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 EKE37079.1 - 0.12 12.4 0.1 0.19 11.8 0.1 1.4 1 1 0 1 1 1 0 AAA domain DUF2992 PF11208.8 EKE37080.1 - 0.37 11.0 27.3 0.47 10.7 27.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) V_ATPase_I PF01496.19 EKE37080.1 - 2.3 6.0 16.8 2.6 5.8 16.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CSTF2_hinge PF14327.6 EKE37080.1 - 2.3 8.7 8.2 0.55 10.7 2.9 2.1 1 1 1 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 RRF PF01765.19 EKE37080.1 - 2.4 8.1 35.5 0.076 13.0 25.9 2.0 1 1 1 2 2 2 0 Ribosome recycling factor Prominin PF05478.11 EKE37080.1 - 3.4 5.5 14.5 4 5.3 14.5 1.0 1 0 0 1 1 1 0 Prominin TMPIT PF07851.13 EKE37080.1 - 5.7 6.1 22.3 7.2 5.7 22.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein SecA_DEAD PF07517.14 EKE37080.1 - 6.8 5.9 14.4 11 5.2 14.3 1.4 1 1 0 1 1 1 0 SecA DEAD-like domain RRM_1 PF00076.22 EKE37081.1 - 2.9e-20 71.8 0.1 3.4e-20 71.6 0.1 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EKE37081.1 - 6.8e-05 22.9 0.1 0.00019 21.5 0.1 1.6 1 1 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 EKE37081.1 - 7.1e-05 22.6 0.0 0.00013 21.8 0.0 1.4 1 1 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.6 EKE37081.1 - 0.0004 20.0 0.0 0.00041 19.9 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE37081.1 - 0.004 17.1 0.0 0.0058 16.6 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 EKE37081.1 - 0.007 16.4 0.0 0.01 15.9 0.0 1.2 1 0 0 1 1 1 1 Limkain b1 SET_assoc PF11767.8 EKE37081.1 - 0.023 14.3 0.0 0.034 13.8 0.0 1.2 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated DOCK-C2 PF14429.6 EKE37082.1 - 8.6e-11 42.0 0.9 2.4e-10 40.6 0.2 2.1 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DHR-2 PF06920.13 EKE37082.1 - 9.7e-11 41.0 16.9 9.7e-11 41.0 16.9 3.8 3 1 0 3 3 3 1 Dock homology region 2 DUF2680 PF10925.8 EKE37082.1 - 0.1 12.6 1.5 0.51 10.4 1.5 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) CREPT PF16566.5 EKE37082.1 - 0.54 10.4 6.3 0.45 10.7 2.0 3.0 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF3837 PF12939.7 EKE37082.1 - 1.5 9.2 7.0 13 6.2 0.9 3.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3837) SLATT_5 PF18160.1 EKE37083.1 - 0.0089 15.4 0.2 0.014 14.7 0.2 1.3 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain family 5 LMBR1 PF04791.16 EKE37083.1 - 0.0091 15.0 0.7 0.0099 14.8 0.7 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF2203 PF09969.9 EKE37083.1 - 0.012 16.3 0.7 0.021 15.5 0.7 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF1415 PF07209.12 EKE37083.1 - 0.024 14.4 0.1 0.042 13.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1415) GIT_CC PF16559.5 EKE37083.1 - 0.31 10.9 0.2 0.31 10.9 0.2 2.4 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1664 PF07889.12 EKE37083.1 - 0.39 10.8 4.2 1 9.4 1.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) SH3_1 PF00018.28 EKE37084.1 - 7.1e-16 57.6 2.7 4.5e-06 26.2 0.0 5.0 5 0 0 5 5 5 4 SH3 domain SH3_9 PF14604.6 EKE37084.1 - 2.8e-14 52.7 0.7 0.005 16.7 0.0 4.3 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 EKE37084.1 - 1.1e-12 47.4 0.5 0.003 17.2 0.0 4.6 4 0 0 4 4 4 4 Variant SH3 domain SH3_3 PF08239.11 EKE37084.1 - 0.013 15.8 0.9 1.6 9.1 0.0 3.4 3 0 0 3 3 3 0 Bacterial SH3 domain SGS PF05002.15 EKE37086.1 - 3.9e-29 100.6 1.9 3.9e-29 100.6 1.9 2.2 2 0 0 2 2 2 1 SGS domain CS PF04969.16 EKE37086.1 - 1.6e-11 45.1 3.1 2.5e-11 44.4 3.1 1.3 1 0 0 1 1 1 1 CS domain Spermine_synth PF01564.17 EKE37086.1 - 0.021 14.2 0.3 0.034 13.6 0.2 1.4 2 0 0 2 2 2 0 Spermine/spermidine synthase domain NKWYS PF10364.9 EKE37086.1 - 0.059 13.5 2.8 0.16 12.1 0.7 2.2 1 1 1 2 2 2 0 Putative capsular polysaccharide synthesis protein Filamin PF00630.19 EKE37086.1 - 0.13 13.1 0.5 0.23 12.3 0.3 1.4 1 1 0 1 1 1 0 Filamin/ABP280 repeat CsgF PF10614.9 EKE37086.1 - 1.7 8.9 4.6 5 7.4 0.1 2.8 2 1 2 4 4 4 0 Type VIII secretion system (T8SS), CsgF protein DAGK_acc PF00609.19 EKE37088.1 - 3.4e-29 102.2 0.0 6.8e-29 101.3 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain C1_1 PF00130.22 EKE37088.1 - 3e-11 43.0 53.1 3.5e-06 26.8 12.0 3.5 3 0 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) DAGK_cat PF00781.24 EKE37088.1 - 5.1e-11 42.3 0.0 1.2e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DUF5600 PF18150.1 EKE37089.1 - 5.7e-37 126.6 0.2 1.2e-36 125.5 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EHD_N PF16880.5 EKE37089.1 - 1.6e-10 40.7 1.2 1.6e-10 40.7 1.2 2.0 2 0 0 2 2 2 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 EKE37089.1 - 0.0006 19.9 0.0 0.0015 18.6 0.0 1.7 1 0 0 1 1 1 1 Dynamin family EF-hand_4 PF12763.7 EKE37089.1 - 0.0016 18.3 0.0 0.0045 16.9 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Cpn60_TCP1 PF00118.24 EKE37090.1 - 5.1e-148 493.7 13.1 5.9e-148 493.5 13.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ras PF00071.22 EKE37092.1 - 2.6e-35 121.4 0.2 4.4e-35 120.7 0.2 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37092.1 - 2.5e-25 89.0 0.0 5.1e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37092.1 - 2.4e-11 43.4 0.2 4e-11 42.7 0.1 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE37092.1 - 0.00031 20.2 0.0 0.00075 18.9 0.0 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE37092.1 - 0.00094 19.2 0.0 0.0023 18.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EKE37092.1 - 0.0027 16.9 2.3 0.68 9.0 0.1 2.8 2 1 1 3 3 3 2 G-protein alpha subunit MMR_HSR1_Xtn PF16897.5 EKE37092.1 - 0.038 14.0 0.1 0.1 12.6 0.1 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 EKE37092.1 - 0.048 13.6 0.1 0.1 12.5 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 EKE37092.1 - 0.05 13.1 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region GTP_EFTU PF00009.27 EKE37092.1 - 0.095 12.2 0.5 0.26 10.8 0.1 1.9 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKE37092.1 - 0.17 11.3 3.4 0.17 11.3 0.1 2.5 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit Pkinase PF00069.25 EKE37094.1 - 1.9e-21 76.6 9.0 6.7e-17 61.7 0.0 3.7 3 1 1 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37094.1 - 5.7e-12 45.5 0.2 1.1e-08 34.6 0.0 3.9 2 2 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.14 EKE37094.1 - 0.00043 19.7 0.0 0.001 18.5 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF647 PF04884.14 EKE37096.1 - 5.6e-27 94.9 3.4 8.8e-27 94.3 3.4 1.3 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis Beach PF02138.18 EKE37098.1 - 8.7e-98 327.1 1.2 8.7e-98 327.1 1.2 2.6 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 EKE37098.1 - 8.9e-10 38.6 2.4 8.9e-10 38.6 2.4 2.3 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 EKE37098.1 - 0.00034 20.8 0.0 0.00065 19.9 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily ANAPC4_WD40 PF12894.7 EKE37098.1 - 0.037 14.3 0.0 0.11 12.8 0.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Apolipoprotein PF01442.18 EKE37098.1 - 0.083 12.8 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Thioredoxin PF00085.20 EKE37099.1 - 1.4e-08 34.6 0.0 1.8e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DUF1340 PF07067.11 EKE37099.1 - 0.029 13.7 0.1 0.038 13.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1340) Thioredoxin_2 PF13098.6 EKE37099.1 - 0.057 13.9 0.0 0.071 13.6 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Indigoidine_A PF04227.12 EKE37100.1 - 1.1e-114 382.7 3.8 1.7e-114 382.1 3.8 1.3 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 EKE37100.1 - 1.9e-36 126.0 0.1 4.4e-36 124.7 0.1 1.6 1 0 0 1 1 1 1 pfkB family carbohydrate kinase ArsD PF06953.11 EKE37100.1 - 0.0004 20.7 0.4 0.089 13.1 0.1 3.2 3 1 0 3 3 3 1 Arsenical resistance operon trans-acting repressor ArsD Phos_pyr_kin PF08543.12 EKE37100.1 - 0.034 13.5 0.0 0.093 12.1 0.0 1.7 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase Hydrolase_3 PF08282.12 EKE37101.1 - 1.3e-42 146.4 9.8 4.7e-42 144.5 9.8 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKE37101.1 - 1.2e-08 34.8 0.8 7e-08 32.3 0.8 1.9 1 1 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EKE37101.1 - 3.3e-07 30.8 0.2 6.4e-07 29.9 0.2 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EKE37101.1 - 9.1e-05 22.9 0.3 0.06 13.7 0.0 3.1 2 2 1 3 3 3 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EKE37101.1 - 0.0024 17.3 1.1 0.03 13.7 0.0 2.4 1 1 0 2 2 2 1 Putative Phosphatase DUF2277 PF10041.9 EKE37101.1 - 0.12 12.8 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2277) HAD_2 PF13419.6 EKE37101.1 - 0.33 11.0 7.6 2.2e+02 1.8 7.6 3.8 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase RabGAP-TBC PF00566.18 EKE37103.1 - 4.3e-29 101.7 1.1 1.1e-28 100.4 1.1 1.7 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ank_2 PF12796.7 EKE37103.1 - 2.8e-25 88.7 3.7 6.4e-09 36.3 0.0 3.8 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE37103.1 - 6e-19 68.2 0.5 1.9e-07 31.5 0.0 5.4 1 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE37103.1 - 1.8e-18 66.3 0.7 1.3e-08 34.9 0.1 5.0 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EKE37103.1 - 4.2e-15 55.4 1.3 0.0051 17.2 0.0 6.6 7 0 0 7 7 7 4 Ankyrin repeat Ank_3 PF13606.6 EKE37103.1 - 6.8e-15 53.7 0.0 0.01 16.3 0.0 6.9 7 0 0 7 7 7 4 Ankyrin repeat ADH_N PF08240.12 EKE37104.1 - 0.03 14.2 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain zf-UBR PF02207.20 EKE37107.1 - 1.6e-15 57.0 21.4 1.6e-15 57.0 21.4 3.7 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) TPR_MLP1_2 PF07926.12 EKE37109.1 - 0.015 15.4 5.4 0.023 14.7 5.4 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein HMMR_N PF15905.5 EKE37109.1 - 0.03 13.8 15.1 0.039 13.4 15.1 1.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF2524 PF10732.9 EKE37109.1 - 0.051 13.9 3.3 1.8 8.9 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) LemA PF04011.12 EKE37109.1 - 0.12 12.2 2.2 0.16 11.9 2.2 1.2 1 0 0 1 1 1 0 LemA family Golgin_A5 PF09787.9 EKE37109.1 - 0.18 11.3 12.9 0.21 11.0 12.9 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 APG6_N PF17675.1 EKE37109.1 - 0.51 10.9 8.8 0.59 10.7 8.1 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region VPS38 PF17649.1 EKE37109.1 - 0.6 8.9 10.4 0.7 8.7 10.4 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting 38 zf-C4H2 PF10146.9 EKE37109.1 - 1.1 9.5 14.5 1.3 9.3 14.5 1.0 1 0 0 1 1 1 0 Zinc finger-containing protein Nup88 PF10168.9 EKE37109.1 - 1.5 6.6 13.2 1.6 6.4 13.2 1.0 1 0 0 1 1 1 0 Nuclear pore component S-antigen PF05756.11 EKE37109.1 - 1.8 9.0 9.7 0.61 10.5 3.3 2.1 1 1 1 2 2 2 0 S-antigen protein Atg14 PF10186.9 EKE37109.1 - 2 7.4 9.1 3.1 6.8 9.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 LCAT PF02450.15 EKE37110.1 - 4.2e-35 121.7 0.0 5.1e-35 121.4 0.0 1.0 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 EKE37110.1 - 0.00029 20.6 0.0 0.0028 17.4 0.0 2.0 2 0 0 2 2 2 1 PGAP1-like protein DUF676 PF05057.14 EKE37110.1 - 0.001 18.6 0.0 0.0019 17.7 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF915 PF06028.11 EKE37110.1 - 0.022 14.1 0.6 0.051 12.9 0.6 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) zf_PR_Knuckle PF18445.1 EKE37110.1 - 0.031 14.1 0.8 0.1 12.5 0.0 2.2 2 0 0 2 2 2 0 PR zinc knuckle motif Abhydrolase_6 PF12697.7 EKE37110.1 - 0.036 14.7 0.0 0.049 14.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family POTRA PF07244.15 EKE37110.1 - 0.05 14.2 0.0 0.18 12.4 0.0 1.9 2 0 0 2 2 2 0 Surface antigen variable number repeat Hydrolase_4 PF12146.8 EKE37110.1 - 0.052 12.8 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 EKE37110.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase_Tyr PF07714.17 EKE37111.1 - 1.8e-30 106.1 0.0 4.2e-30 104.9 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37111.1 - 4.1e-26 91.9 0.0 1e-25 90.6 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain VSP PF03302.13 EKE37111.1 - 0.065 12.1 122.7 0.041 12.8 36.2 5.2 1 1 4 5 5 5 0 Giardia variant-specific surface protein Ribosomal_L36e PF01158.18 EKE37113.1 - 1e-27 96.2 3.9 1.2e-27 95.9 3.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e DUF531 PF04407.12 EKE37113.1 - 0.065 13.3 0.2 5.2 7.1 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF531) Mistic PF11458.8 EKE37113.1 - 0.18 11.8 0.0 0.59 10.1 0.0 1.8 2 0 0 2 2 2 0 Membrane-integrating protein Mistic TetR PF13972.6 EKE37114.1 - 0.053 13.2 0.1 5.6 6.7 0.0 2.5 2 0 0 2 2 2 0 Bacterial transcriptional repressor DOCK-C2 PF14429.6 EKE37115.1 - 9.9e-27 94.0 0.0 2.7e-26 92.6 0.0 1.8 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Endonuc-PvuII PF09225.10 EKE37115.1 - 0.018 14.8 3.5 0.066 13.0 1.2 2.6 2 0 0 2 2 2 0 Restriction endonuclease PvuII EF-hand_6 PF13405.6 EKE37115.1 - 0.031 14.2 1.4 0.73 9.9 0.2 3.7 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.6 EKE37115.1 - 0.72 10.3 4.6 0.84 10.1 0.6 3.1 3 0 0 3 3 3 0 EF-hand domain pair COPIIcoated_ERV PF07970.12 EKE37117.1 - 1.5e-58 198.2 0.9 1.5e-58 198.2 0.9 1.4 2 0 0 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EKE37117.1 - 1.3e-24 86.3 0.1 1.3e-24 86.3 0.1 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF4094 PF13334.6 EKE37118.1 - 0.0014 19.0 0.2 0.0014 19.0 0.2 2.4 3 1 0 3 3 3 1 Domain of unknown function (DUF4094) CARD PF00619.21 EKE37118.1 - 0.068 13.2 0.5 0.18 11.9 0.3 1.9 2 0 0 2 2 2 0 Caspase recruitment domain DUF2951 PF11166.8 EKE37118.1 - 0.11 12.7 6.4 0.28 11.4 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2951) GrpE PF01025.19 EKE37118.1 - 0.24 11.1 9.4 0.075 12.7 4.4 2.4 1 1 1 2 2 2 0 GrpE DUF948 PF06103.11 EKE37118.1 - 0.34 11.2 8.3 4.7 7.5 1.3 3.8 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) bZIP_1 PF00170.21 EKE37119.1 - 0.0048 17.0 9.8 0.0048 17.0 9.8 2.9 2 0 0 2 2 2 1 bZIP transcription factor TSC22 PF01166.18 EKE37119.1 - 0.0099 16.2 2.2 0.0099 16.2 2.2 2.8 2 0 0 2 2 2 1 TSC-22/dip/bun family PMC2NT PF08066.12 EKE37119.1 - 0.022 15.4 0.4 0.12 13.1 0.4 2.4 1 0 0 1 1 1 0 PMC2NT (NUC016) domain TSNAXIP1_N PF15739.5 EKE37119.1 - 0.19 12.1 13.3 0.075 13.4 9.9 2.2 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus DUF4407 PF14362.6 EKE37119.1 - 0.3 10.4 12.4 0.64 9.3 12.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FTCD_C PF04961.12 EKE37119.1 - 0.33 10.7 6.1 3.1 7.5 4.3 2.9 2 1 1 3 3 3 0 Formiminotransferase-cyclodeaminase COG5 PF10392.9 EKE37119.1 - 0.82 9.8 5.1 0.74 10.0 0.3 2.8 3 0 0 3 3 3 0 Golgi transport complex subunit 5 KfrA_N PF11740.8 EKE37119.1 - 1.3 9.7 5.5 46 4.7 5.5 2.3 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term Occludin_ELL PF07303.13 EKE37119.1 - 4.4 8.1 24.2 0.49 11.2 9.6 3.4 2 1 1 3 3 3 0 Occludin homology domain MnhB PF04039.13 EKE37120.1 - 0.014 15.7 7.6 0.014 15.7 7.6 2.1 2 0 0 2 2 2 0 Domain related to MnhB subunit of Na+/H+ antiporter CRPA PF05745.11 EKE37120.1 - 0.14 12.1 11.1 0.5 10.4 0.7 3.2 3 0 0 3 3 3 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Tetraspanin PF00335.20 EKE37120.1 - 0.28 10.8 20.6 0.8 9.4 20.6 1.7 1 1 0 1 1 1 0 Tetraspanin family Deltameth_res PF16020.5 EKE37120.1 - 4 7.4 5.5 1.2 9.1 0.3 2.7 2 0 0 2 2 2 0 Deltamethrin resistance Tmemb_55A PF09788.9 EKE37120.1 - 8.4 5.4 7.7 1 8.4 3.5 1.6 2 0 0 2 2 2 0 Transmembrane protein 55A Ribosomal_S13 PF00416.22 EKE37121.1 - 4.4e-49 166.1 0.6 5.1e-49 165.9 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Period_C PF12114.8 EKE37121.1 - 0.071 12.7 0.0 0.097 12.2 0.0 1.1 1 0 0 1 1 1 0 Period protein 2/3C-terminal region DUF2746 PF10874.8 EKE37121.1 - 0.097 13.1 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) Mlf1IP PF10248.9 EKE37122.1 - 0.0038 17.2 3.3 0.0057 16.7 3.3 1.2 1 0 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein PatG_D PF18047.1 EKE37122.1 - 0.1 13.0 0.4 0.22 11.9 0.1 1.6 2 0 0 2 2 2 0 PatG Domain DUF4038 PF13204.6 EKE37123.1 - 0.051 13.2 0.1 0.058 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) Helicase_C PF00271.31 EKE37124.1 - 1.7e-06 28.4 0.0 1.7e-06 28.4 0.0 4.4 3 2 1 4 4 4 1 Helicase conserved C-terminal domain Chromo PF00385.24 EKE37124.1 - 1.3e-05 25.0 9.4 7.1e-05 22.6 0.4 4.1 4 0 0 4 4 4 2 Chromo (CHRromatin Organisation MOdifier) domain GNAT_C PF18164.1 EKE37124.1 - 0.066 12.9 0.3 0.22 11.2 0.3 2.0 1 0 0 1 1 1 0 GNAT-like C-terminal domain FeoB_C PF07664.12 EKE37124.1 - 1 9.1 2.5 4.4 7.1 0.0 3.1 3 0 0 3 3 3 0 Ferrous iron transport protein B C terminus FAST_2 PF08368.12 EKE37124.1 - 1.2 9.9 4.9 36 5.2 0.2 3.7 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 2 LCAT PF02450.15 EKE37125.1 - 1.4e-41 143.0 2.2 2.4e-39 135.6 0.5 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 EKE37125.1 - 3.2e-07 30.3 0.0 6.3e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 EKE37125.1 - 9.7e-05 22.3 0.0 0.00018 21.5 0.0 1.5 1 1 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 EKE37125.1 - 0.00011 21.8 0.0 0.00023 20.7 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EKE37125.1 - 0.0002 20.7 0.0 0.00037 19.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF915 PF06028.11 EKE37125.1 - 0.00033 20.1 0.2 0.0085 15.4 0.0 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Chlorophyllase2 PF12740.7 EKE37125.1 - 0.00038 19.4 0.0 0.17 10.8 0.0 2.3 2 0 0 2 2 2 2 Chlorophyllase enzyme Abhydrolase_1 PF00561.20 EKE37125.1 - 0.00044 20.0 0.0 0.0007 19.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKE37125.1 - 0.00083 20.0 0.0 0.0027 18.3 0.0 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EKE37125.1 - 0.00094 19.1 0.0 0.021 14.7 0.0 2.2 2 0 0 2 2 2 1 Serine hydrolase LIDHydrolase PF10230.9 EKE37125.1 - 0.0086 15.7 0.0 0.021 14.4 0.0 1.6 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase baeRF_family5 PF18846.1 EKE37125.1 - 0.012 15.9 0.2 4.8 7.4 0.0 2.5 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 5 Abhydrolase_5 PF12695.7 EKE37125.1 - 0.017 14.9 0.0 0.4 10.4 0.0 2.8 3 0 0 3 3 3 0 Alpha/beta hydrolase family Esterase PF00756.20 EKE37125.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative esterase DUF900 PF05990.12 EKE37125.1 - 0.11 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_3 PF01764.25 EKE37125.1 - 0.14 12.1 0.0 0.44 10.4 0.0 1.9 2 0 0 2 2 2 0 Lipase (class 3) PhoLip_ATPase_C PF16212.5 EKE37126.1 - 1.2e-57 195.5 36.4 1.2e-57 195.5 36.4 3.1 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EKE37126.1 - 2.3e-22 78.4 4.4 2.3e-22 78.4 4.4 4.7 6 0 0 6 6 6 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EKE37126.1 - 2.1e-11 43.7 0.8 1.6e-10 40.9 0.7 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EKE37126.1 - 2.7e-11 44.2 0.1 2.1e-06 28.2 0.0 3.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EKE37126.1 - 2.6e-06 27.1 0.0 2.6e-06 27.1 0.0 3.0 3 0 0 3 3 3 1 E1-E2 ATPase ANAPC3 PF12895.7 EKE37127.1 - 0.044 14.0 0.8 0.17 12.1 0.8 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Myb_DNA-bind_7 PF15963.5 EKE37128.1 - 1.2e-22 79.6 0.8 1.2e-22 79.6 0.8 1.7 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EKE37128.1 - 2.3e-07 30.9 0.0 3.8e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE37128.1 - 5.7e-05 23.3 0.0 0.00014 22.0 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ribosomal_S17e PF00833.18 EKE37129.1 - 2e-56 189.2 1.1 2.1e-56 189.1 1.1 1.0 1 0 0 1 1 1 1 Ribosomal S17 PSS PF03034.15 EKE37130.1 - 7.9e-102 340.7 18.7 7.9e-102 340.7 18.7 1.5 2 0 0 2 2 2 1 Phosphatidyl serine synthase Competence PF03772.16 EKE37130.1 - 0.0017 17.7 0.2 0.0017 17.7 0.2 2.7 2 1 0 2 2 2 1 Competence protein 1-cysPrx_C PF10417.9 EKE37131.1 - 0.0086 15.9 0.1 0.021 14.7 0.1 1.7 1 1 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Ras PF00071.22 EKE37132.1 - 1.7e-20 73.2 0.1 2.1e-20 72.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37132.1 - 4.7e-17 62.3 0.0 7e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EKE37132.1 - 2e-05 24.1 0.1 2.6e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EKE37132.1 - 0.00021 20.8 0.0 0.00033 20.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_24 PF13479.6 EKE37132.1 - 0.0014 18.4 0.1 0.003 17.3 0.1 1.5 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EKE37132.1 - 0.0054 16.8 0.0 0.0082 16.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE37132.1 - 0.014 14.9 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE37132.1 - 0.029 13.9 0.0 0.24 10.9 0.0 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EKE37132.1 - 0.034 14.4 0.0 0.088 13.1 0.0 1.7 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 EKE37132.1 - 0.037 13.4 0.0 0.37 10.2 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_18 PF13238.6 EKE37132.1 - 0.07 13.7 0.1 0.11 13.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EKE37132.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MeaB PF03308.16 EKE37132.1 - 0.3 10.0 0.0 0.42 9.6 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB BLOC1_2 PF10046.9 EKE37133.1 - 0.0075 16.5 0.5 0.0075 16.5 0.5 2.1 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 EKE37133.1 - 2.9 7.7 10.2 0.27 11.0 1.0 3.4 4 0 0 4 4 4 0 Septum formation initiator DUF2240 PF09999.9 EKE37134.1 - 0.079 12.6 0.1 0.19 11.3 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2240) Far-17a_AIG1 PF04750.14 EKE37135.1 - 1.9e-10 40.4 13.6 2.6e-10 39.9 13.6 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein DUF2130 PF09903.9 EKE37135.1 - 0.095 11.9 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) IBR PF01485.21 EKE37136.1 - 1.7e-10 41.0 11.6 2e-10 40.8 11.6 1.1 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain zf-RING_4 PF14570.6 EKE37136.1 - 0.01 15.6 14.0 0.16 11.8 14.4 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 EKE37136.1 - 0.2 11.8 5.7 0.2 11.8 1.2 2.0 1 1 1 2 2 2 0 Zinc-binding RING-finger zf-C3HC4_3 PF13920.6 EKE37136.1 - 0.38 10.7 12.6 0.56 10.1 0.6 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE37136.1 - 1.6 8.7 14.0 5.8 6.9 13.6 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE37137.1 - 1.2e-07 31.6 6.7 2.2e-07 30.8 6.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EKE37137.1 - 8.6e-06 26.0 7.5 1.4e-05 25.3 7.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EKE37137.1 - 2.9e-05 23.9 4.6 6.1e-05 22.8 4.6 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EKE37137.1 - 0.00019 21.6 8.8 0.0017 18.4 9.1 2.1 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EKE37137.1 - 0.00069 19.5 8.0 0.00069 19.5 8.0 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EKE37137.1 - 0.0012 18.7 6.5 0.0013 18.6 5.6 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_5 PF17121.5 EKE37137.1 - 0.025 14.5 8.9 0.081 12.8 8.9 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EKE37137.1 - 0.042 13.6 4.5 0.091 12.6 4.5 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Transpos_assoc PF13963.6 EKE37137.1 - 0.058 13.7 3.4 0.72 10.2 1.2 2.2 2 0 0 2 2 2 0 Transposase-associated domain Ribosomal_L27A PF00828.19 EKE37137.1 - 0.19 12.4 0.0 1.4 9.6 0.0 1.9 2 0 0 2 2 2 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Prok-RING_4 PF14447.6 EKE37137.1 - 0.2 11.6 8.7 2.7 7.9 0.0 2.5 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 IBR PF01485.21 EKE37137.1 - 0.42 10.9 11.0 0.86 9.9 3.9 2.4 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-RAG1 PF10426.9 EKE37137.1 - 2.7 8.2 6.8 0.32 11.2 1.5 2.0 2 0 0 2 2 2 0 Recombination-activating protein 1 zinc-finger domain zf-RING_11 PF17123.5 EKE37137.1 - 6 6.7 9.9 0.58 9.9 5.4 1.7 2 0 0 2 2 2 0 RING-like zinc finger DUF4064 PF13273.6 EKE37139.1 - 0.0062 16.8 1.0 0.0062 16.8 1.0 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF4064) UPF0258 PF06789.12 EKE37139.1 - 0.014 15.6 2.3 0.031 14.4 2.3 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0258) DUF2207 PF09972.9 EKE37139.1 - 0.046 12.5 0.4 0.051 12.3 0.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1461 PF07314.11 EKE37139.1 - 0.057 13.3 4.1 0.089 12.7 4.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1461) TMIE PF16038.5 EKE37139.1 - 6.8 6.6 7.1 8.6 6.3 2.3 2.4 2 1 0 2 2 2 0 TMIE protein DpnII-MboI PF18742.1 EKE37141.1 - 0.1 12.2 2.1 0.26 10.9 0.4 2.0 1 1 1 2 2 2 0 REase_DpnII-MboI NHL PF01436.21 EKE37143.1 - 1.3e-12 47.1 12.2 1.1e-05 25.3 0.0 5.2 6 0 0 6 6 6 3 NHL repeat SGL PF08450.12 EKE37143.1 - 9.4e-05 22.1 0.1 0.043 13.4 0.0 2.5 1 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region MtrB PF05440.12 EKE37143.1 - 0.024 15.0 0.0 0.064 13.7 0.0 1.7 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase subunit B BAH PF01426.18 EKE37143.1 - 0.038 13.8 0.2 0.12 12.3 0.1 1.9 2 0 0 2 2 2 0 BAH domain NLRC4_HD2 PF17776.1 EKE37143.1 - 0.087 13.4 2.2 0.18 12.4 2.2 1.5 1 0 0 1 1 1 0 NLRC4 helical domain HD2 STAT_alpha PF01017.20 EKE37143.1 - 0.26 11.2 6.4 0.43 10.5 6.4 1.3 1 0 0 1 1 1 0 STAT protein, all-alpha domain Oxysterol_BP PF01237.18 EKE37144.1 - 2e-75 254.0 6.5 5.9e-69 232.7 0.1 2.1 1 1 1 2 2 2 2 Oxysterol-binding protein Duffy_binding PF05424.11 EKE37144.1 - 0.78 9.8 6.1 0.079 13.0 1.3 1.7 2 0 0 2 2 2 0 Duffy binding domain HUN PF08729.10 EKE37146.1 - 0.04 13.9 0.2 0.04 13.9 0.2 2.7 3 0 0 3 3 3 0 HPC2 and ubinuclein domain EF-hand_6 PF13405.6 EKE37147.1 - 2.2e-16 58.3 6.5 2.8e-06 26.8 0.8 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 EKE37147.1 - 8.5e-16 56.3 12.2 2.5e-05 23.5 1.4 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EKE37147.1 - 9.7e-16 58.0 6.0 6e-11 42.6 4.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EKE37147.1 - 1.1e-10 41.2 10.2 1.3e-05 24.9 1.3 3.9 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 EKE37147.1 - 6.1e-06 26.5 0.6 0.035 14.4 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EKE37147.1 - 0.00041 19.7 8.8 0.5 9.9 0.2 3.7 3 0 0 3 3 3 2 EF hand Caleosin PF05042.13 EKE37147.1 - 0.0024 17.8 0.9 6 6.8 0.1 3.0 1 1 2 3 3 3 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 EKE37147.1 - 0.0025 18.1 1.5 0.12 12.7 0.8 2.1 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF2666 PF10869.8 EKE37147.1 - 0.0063 16.7 2.2 0.86 9.8 0.1 2.2 1 1 0 2 2 2 2 Protein of unknown function (DUF2666) DUF1456 PF07308.13 EKE37147.1 - 0.0087 16.4 0.9 0.023 15.0 0.5 1.9 1 1 0 2 2 2 1 Protein of unknown function (DUF1456) Adenine_glyco PF03352.13 EKE37147.1 - 0.013 15.3 0.3 0.024 14.4 0.3 1.5 1 1 0 1 1 1 0 Methyladenine glycosylase EF-hand_14 PF17959.1 EKE37147.1 - 0.02 15.3 0.7 0.34 11.3 0.4 2.4 1 1 1 2 2 2 0 EF-hand domain p25-alpha PF05517.12 EKE37147.1 - 0.064 13.4 6.8 0.12 12.5 6.5 1.6 1 1 0 1 1 1 0 p25-alpha EF-hand_4 PF12763.7 EKE37147.1 - 0.092 12.7 1.3 0.2 11.6 0.7 1.8 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Aminotran_1_2 PF00155.21 EKE37148.1 - 3.5e-10 39.6 0.0 4.1e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Peptidase_C25 PF01364.18 EKE37148.1 - 0.095 11.9 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase family C25 Beta_elim_lyase PF01212.21 EKE37148.1 - 0.11 11.8 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase Cullin PF00888.22 EKE37149.1 - 7.2e-79 266.0 32.9 9.2e-79 265.7 32.9 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EKE37149.1 - 5.6e-20 71.1 5.8 5.6e-20 71.1 5.8 3.3 3 0 0 3 3 3 1 Cullin protein neddylation domain DUF2750 PF11042.8 EKE37149.1 - 0.038 14.0 0.0 0.29 11.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2750) Pkinase PF00069.25 EKE37150.1 - 4.8e-70 235.9 1.6 6.2e-70 235.6 1.6 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37150.1 - 3.2e-31 108.6 0.3 4.5e-31 108.1 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE37150.1 - 4.8e-07 29.4 0.0 7.6e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EKE37150.1 - 7.5e-05 22.4 0.2 0.00016 21.4 0.2 1.5 1 0 0 1 1 1 1 RIO1 family FHA PF00498.26 EKE37150.1 - 8.7e-05 22.8 0.0 0.0002 21.6 0.0 1.6 1 0 0 1 1 1 1 FHA domain FTA2 PF13095.6 EKE37150.1 - 0.00013 21.7 0.7 0.15 11.7 0.1 2.3 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EKE37150.1 - 0.00019 20.9 0.0 0.00036 19.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKE37150.1 - 0.0072 15.1 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 EKE37150.1 - 0.017 14.7 0.7 0.15 11.7 0.3 2.4 2 1 0 2 2 2 0 Choline/ethanolamine kinase APH PF01636.23 EKE37150.1 - 0.14 12.1 0.0 0.35 10.8 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF4661 PF15576.6 EKE37151.1 - 1.1 9.2 6.1 0.64 9.9 4.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4661) TMC PF07810.13 EKE37152.1 - 9.6e-05 22.9 0.6 9.6e-05 22.9 0.6 3.1 2 1 1 3 3 3 1 TMC domain Baculo_11_kDa PF06143.11 EKE37152.1 - 0.026 14.1 0.6 0.026 14.1 0.6 3.0 3 1 1 4 4 4 0 Baculovirus 11 kDa family TMCO5 PF14992.6 EKE37152.1 - 0.051 13.2 0.7 0.095 12.3 0.7 1.5 1 0 0 1 1 1 0 TMCO5 family RabGAP-TBC PF00566.18 EKE37153.1 - 5.9e-16 58.8 4.4 1e-15 58.0 4.4 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PHP PF02811.19 EKE37153.1 - 0.077 13.3 0.0 0.15 12.3 0.0 1.7 1 1 0 1 1 1 0 PHP domain zf-RING_5 PF14634.6 EKE37155.1 - 4.4e-07 29.7 7.2 1.3e-06 28.2 7.2 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EKE37155.1 - 4.9e-05 23.6 6.1 4.9e-05 23.6 6.1 2.2 2 0 0 2 2 2 1 Ring finger domain Zn_ribbon_17 PF17120.5 EKE37155.1 - 0.00023 20.7 5.2 0.00075 19.1 5.2 2.0 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EKE37155.1 - 0.0011 18.6 8.2 0.0011 18.6 8.2 2.6 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EKE37155.1 - 0.0052 16.6 2.2 0.0052 16.6 2.2 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EKE37155.1 - 0.0095 16.2 7.4 0.04 14.2 7.4 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EKE37155.1 - 0.012 15.6 2.1 0.012 15.6 2.1 2.2 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_6 PF14835.6 EKE37155.1 - 0.066 13.1 0.3 0.19 11.6 0.3 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 EKE37155.1 - 0.11 12.4 3.6 0.76 9.7 3.6 2.4 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Cys_rich_CPXG PF14255.6 EKE37155.1 - 0.57 10.1 5.2 3.2 7.7 0.1 3.2 3 0 0 3 3 3 0 Cysteine-rich CPXCG zf-C3HC4 PF00097.25 EKE37155.1 - 0.88 9.5 15.1 0.027 14.3 7.6 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H_2 PF13832.6 EKE37155.1 - 1.4 9.1 6.3 3.1 8.0 4.7 2.4 2 0 0 2 2 2 0 PHD-zinc-finger like domain Zf_RING PF16744.5 EKE37155.1 - 1.6 8.9 6.8 0.39 10.9 2.1 2.4 3 0 0 3 3 2 0 KIAA1045 RING finger zf-C3H2C3 PF17122.5 EKE37155.1 - 2 8.5 7.0 0.49 10.5 1.2 2.5 2 0 0 2 2 2 0 Zinc-finger AHD PF17793.1 EKE37155.1 - 2.2 8.1 6.8 10 6.0 0.1 3.8 4 0 0 4 4 4 0 ANC1 homology domain (AHD) Prok-RING_1 PF14446.6 EKE37155.1 - 6.2 6.8 6.5 4.2 7.4 2.1 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD PF00628.29 EKE37155.1 - 9.6 6.2 9.0 2.2 8.2 4.9 2.2 2 0 0 2 2 2 0 PHD-finger Taeniidae_ag PF05596.11 EKE37156.1 - 0.097 12.7 0.0 0.35 10.9 0.0 1.9 1 1 0 1 1 1 0 Taeniidae antigen WW PF00397.26 EKE37157.1 - 1.7e-07 31.2 0.9 3.1e-07 30.3 0.9 1.5 1 0 0 1 1 1 1 WW domain ATPgrasp_ST PF14397.6 EKE37157.1 - 0.018 14.3 0.1 0.047 12.9 0.1 1.6 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp YceD PF02620.17 EKE37157.1 - 0.1 12.7 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Large ribosomal RNA subunit accumulation protein YceD AAA PF00004.29 EKE37158.1 - 2.1e-46 157.6 0.0 1.6e-39 135.4 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKE37158.1 - 9.2e-10 38.2 0.1 1.1e-08 34.7 0.1 2.6 3 0 0 3 3 3 1 AAA+ lid domain AAA_16 PF13191.6 EKE37158.1 - 2.5e-07 31.2 0.0 0.007 16.8 0.0 3.6 2 2 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EKE37158.1 - 2.5e-07 31.0 1.0 0.026 14.8 0.0 3.8 2 2 1 3 3 3 2 AAA domain RuvB_N PF05496.12 EKE37158.1 - 6.3e-07 29.3 0.0 0.00061 19.6 0.0 3.2 2 1 1 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EKE37158.1 - 2.7e-05 24.2 0.0 0.4 10.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EKE37158.1 - 2.7e-05 24.4 0.0 0.05 13.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EKE37158.1 - 7.4e-05 22.8 0.0 0.049 13.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EKE37158.1 - 0.0001 22.7 0.0 0.2 12.1 0.0 3.0 3 0 0 3 3 2 2 RNA helicase AAA_7 PF12775.7 EKE37158.1 - 0.00012 21.6 0.0 0.15 11.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region NACHT PF05729.12 EKE37158.1 - 0.00032 20.7 0.7 2.7 7.9 0.0 3.5 2 1 1 3 3 3 1 NACHT domain IstB_IS21 PF01695.17 EKE37158.1 - 0.00034 20.4 0.0 0.52 10.0 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_2 PF07724.14 EKE37158.1 - 0.0015 18.6 0.0 0.34 11.0 0.0 2.7 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) Rad17 PF03215.15 EKE37158.1 - 0.0022 18.0 0.0 2.6 8.0 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain TIP49 PF06068.13 EKE37158.1 - 0.011 14.9 0.0 0.35 10.0 0.0 2.4 2 0 0 2 2 2 0 TIP49 P-loop domain Mg_chelatase PF01078.21 EKE37158.1 - 0.022 14.1 0.0 1.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 EKE37158.1 - 0.026 15.0 0.0 0.16 12.5 0.0 2.2 2 0 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 EKE37158.1 - 0.039 13.7 0.0 0.73 9.5 0.0 2.6 3 0 0 3 3 2 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EKE37158.1 - 0.042 14.0 0.0 8.9 6.4 0.0 2.8 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF815 PF05673.13 EKE37158.1 - 0.054 12.7 0.0 2.6 7.2 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 EKE37158.1 - 0.073 13.3 0.0 2.8 8.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EKE37158.1 - 0.075 13.6 0.0 0.72 10.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EKE37158.1 - 0.08 12.7 0.0 7.4 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 EKE37158.1 - 0.094 12.1 0.0 3.3 7.1 0.0 2.6 3 0 0 3 3 3 0 Bacterial TniB protein RsgA_GTPase PF03193.16 EKE37158.1 - 0.11 12.4 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase ATP-synt_ab PF00006.25 EKE37158.1 - 0.19 11.3 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain LRR_5 PF13306.6 EKE37160.1 - 7.5e-74 245.8 49.0 4.8e-33 113.8 9.9 4.0 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE37160.1 - 7.5e-12 44.8 1.5 0.003 17.3 0.0 6.0 1 1 8 9 9 9 8 Leucine rich repeat LAG1-DNAbind PF09271.11 EKE37162.1 - 0.076 13.6 0.2 0.076 13.6 0.2 2.7 2 1 0 2 2 2 0 LAG1, DNA binding Peptidase_U57 PF05582.12 EKE37162.1 - 0.12 11.6 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 YabG peptidase U57 CS PF04969.16 EKE37162.1 - 0.23 12.5 2.1 24 6.1 2.1 2.7 1 1 0 1 1 1 0 CS domain Dynamin_M PF01031.20 EKE37163.1 - 1.2e-82 277.3 1.3 1.2e-82 277.3 1.3 2.0 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EKE37163.1 - 3.5e-47 160.6 0.0 1.1e-46 158.9 0.0 1.9 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EKE37163.1 - 3.3e-26 91.3 3.9 3.3e-26 91.3 3.9 2.3 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EKE37163.1 - 3.9e-05 23.7 0.0 0.00017 21.6 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EKE37163.1 - 0.14 12.5 0.1 2.3 8.6 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain DpnD-PcfM PF14207.6 EKE37165.1 - 0.058 13.3 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 DpnD/PcfM-like protein Glyco_hydro_31 PF01055.26 EKE37166.1 - 5e-122 408.3 13.7 6.6e-122 407.8 13.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EKE37166.1 - 1.1e-05 25.6 0.2 1.1e-05 25.6 0.2 3.2 4 0 0 4 4 4 1 Galactose mutarotase-like DUF5110 PF17137.4 EKE37166.1 - 0.21 11.9 3.7 0.31 11.3 2.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5110) F_actin_bund_C PF18060.1 EKE37167.1 - 1.6e-17 63.4 19.8 1.6e-17 63.4 19.8 4.1 2 2 1 3 3 3 1 F actin bundling C terminal DUF572 PF04502.13 EKE37167.1 - 9.8 5.7 27.3 13 5.2 27.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Calpain_III PF01067.22 EKE37168.1 - 3.2e-36 124.7 0.1 1.5e-13 51.2 0.0 3.7 3 0 0 3 3 3 3 Calpain large subunit, domain III Pkinase PF00069.25 EKE37169.1 - 2e-57 194.6 0.0 3.9e-57 193.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Ras PF00071.22 EKE37169.1 - 3.3e-55 186.1 0.4 5.8e-55 185.3 0.4 1.4 1 0 0 1 1 1 1 Ras family Pkinase_Tyr PF07714.17 EKE37169.1 - 3.1e-42 144.7 0.0 5e-42 144.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Roc PF08477.13 EKE37169.1 - 1.9e-31 108.7 0.2 4.9e-31 107.4 0.1 1.8 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37169.1 - 3.4e-13 49.4 0.1 6.7e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Pkinase_fungal PF17667.1 EKE37169.1 - 0.00026 19.9 0.0 0.00061 18.7 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EKE37169.1 - 0.002 17.5 0.0 0.0041 16.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EKE37169.1 - 0.0035 16.4 0.0 0.0074 15.4 0.0 1.5 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 EKE37169.1 - 0.0082 16.1 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EKE37169.1 - 0.015 14.3 0.0 0.035 13.0 0.0 1.6 1 0 0 1 1 1 0 Haspin like kinase domain MMR_HSR1 PF01926.23 EKE37169.1 - 0.047 13.8 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 EKE37169.1 - 0.09 12.2 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Peptidase_M8 PF01457.16 EKE37170.1 - 1.5e-65 221.9 4.7 2.1e-65 221.4 4.7 1.1 1 0 0 1 1 1 1 Leishmanolysin TIG PF01833.24 EKE37170.1 - 0.00021 21.3 0.0 0.00065 19.7 0.0 1.9 1 0 0 1 1 1 1 IPT/TIG domain Topoisom_bac PF01131.20 EKE37171.1 - 6.5e-108 361.4 0.0 8.3e-108 361.0 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EKE37171.1 - 2e-14 53.6 0.0 6.6e-14 52.0 0.0 2.0 1 0 0 1 1 1 1 Toprim domain RalF_SCD PF18248.1 EKE37171.1 - 0.04 13.9 0.0 0.089 12.7 0.0 1.6 1 0 0 1 1 1 0 RalF C-terminal Sec-7 capping domain PRD PF00874.20 EKE37171.1 - 0.087 13.1 0.4 0.3 11.4 0.4 1.9 1 0 0 1 1 1 0 PRD domain LRR_4 PF12799.7 EKE37172.1 - 1.6e-13 50.6 25.3 0.015 15.7 0.2 10.6 8 4 3 11 11 11 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE37172.1 - 8.3e-10 38.3 14.9 0.23 11.3 0.0 7.8 7 1 0 7 7 7 4 Leucine rich repeat LRR_6 PF13516.6 EKE37172.1 - 1.6e-08 33.9 6.3 1.9 8.8 0.0 9.5 12 0 0 12 12 12 2 Leucine Rich repeat F-box PF00646.33 EKE37172.1 - 9.3e-08 31.8 0.1 3.7e-07 29.9 0.1 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EKE37172.1 - 2e-05 24.4 0.2 0.0001 22.1 0.0 2.3 2 0 0 2 2 2 1 F-box-like LRR_1 PF00560.33 EKE37172.1 - 0.17 12.5 15.3 11 7.0 0.4 8.6 9 1 0 9 9 9 0 Leucine Rich Repeat Post_transc_reg PF13797.6 EKE37172.1 - 0.18 11.7 2.2 3.6 7.5 0.2 3.0 3 0 0 3 3 3 0 Post-transcriptional regulator Thioredoxin PF00085.20 EKE37173.1 - 9.9e-31 105.8 0.0 1.3e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EKE37173.1 - 1.2e-08 35.4 0.0 2.5e-08 34.4 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EKE37173.1 - 1.2e-08 34.7 0.3 1.4e-08 34.4 0.3 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 EKE37173.1 - 2.1e-08 34.0 0.0 2.7e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EKE37173.1 - 1.6e-05 25.2 0.0 0.0024 18.1 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like Redoxin PF08534.10 EKE37173.1 - 0.0003 20.5 0.2 0.023 14.4 0.1 2.1 1 1 1 2 2 2 1 Redoxin Thioredoxin_7 PF13899.6 EKE37173.1 - 0.0013 18.8 0.0 0.0022 18.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 EKE37173.1 - 0.0023 17.8 0.0 0.0032 17.3 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein AhpC-TSA PF00578.21 EKE37173.1 - 0.0099 15.8 0.2 0.11 12.4 0.1 2.0 1 1 1 2 2 2 1 AhpC/TSA family HyaE PF07449.11 EKE37173.1 - 0.012 15.6 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 EKE37173.1 - 0.022 15.0 0.0 0.04 14.1 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin DSBA PF01323.20 EKE37173.1 - 0.2 11.4 0.1 7.6 6.3 0.0 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain ATP_bind_1 PF03029.17 EKE37174.1 - 1.3e-78 264.2 0.3 1.4e-78 264.0 0.3 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 EKE37174.1 - 3.2e-06 27.0 0.0 5.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.5 EKE37174.1 - 0.00029 20.7 0.0 0.0028 17.5 0.0 2.2 2 1 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop TRADD_N PF09034.10 EKE37174.1 - 0.0022 18.0 0.1 0.0045 17.0 0.1 1.6 1 0 0 1 1 1 1 TRADD, N-terminal domain AAA_18 PF13238.6 EKE37174.1 - 0.0078 16.8 0.0 0.017 15.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKE37174.1 - 0.0082 16.4 0.0 0.015 15.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EKE37174.1 - 0.01 15.7 0.0 3.9 7.3 0.0 2.8 3 0 0 3 3 3 0 RsgA GTPase AAA_31 PF13614.6 EKE37174.1 - 0.029 14.3 0.0 11 5.9 0.0 2.5 1 1 1 2 2 2 0 AAA domain RNA_helicase PF00910.22 EKE37174.1 - 0.036 14.5 0.0 0.094 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 EKE37174.1 - 0.05 13.3 0.0 0.073 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 EKE37174.1 - 0.052 12.9 0.5 9.8 5.4 0.1 2.9 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EKE37174.1 - 0.069 13.5 0.0 0.32 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_PrkA PF08298.11 EKE37174.1 - 0.094 11.6 0.0 0.27 10.1 0.0 1.7 2 0 0 2 2 2 0 PrkA AAA domain AAA_29 PF13555.6 EKE37174.1 - 0.098 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP54 PF00448.22 EKE37174.1 - 0.099 12.3 0.0 0.23 11.1 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ATPase_2 PF01637.18 EKE37174.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Cytidylate_kin PF02224.18 EKE37174.1 - 0.18 11.5 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase Ribosomal_60s PF00428.19 EKE37175.1 - 7.5e-14 52.1 11.5 9.1e-14 51.8 11.5 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF2798 PF11391.8 EKE37175.1 - 0.14 12.2 0.3 0.27 11.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2798) Cytomega_UL84 PF06284.11 EKE37175.1 - 1.1 7.7 3.3 1.4 7.3 3.3 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Ribosomal_60s PF00428.19 EKE37176.1 - 1.8e-19 70.1 8.5 2.3e-19 69.8 8.5 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cytomega_UL84 PF06284.11 EKE37176.1 - 0.025 13.1 0.9 0.026 13.0 0.9 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Bot1p PF12298.8 EKE37176.1 - 0.03 14.5 2.4 0.035 14.3 2.4 1.0 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein DUF3824 PF12868.7 EKE37176.1 - 0.036 14.7 2.0 0.053 14.2 2.0 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) TMEM214 PF10151.9 EKE37176.1 - 0.09 11.2 0.3 0.11 10.9 0.3 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator DUF2569 PF10754.9 EKE37177.1 - 0.011 16.2 16.8 0.013 16.0 2.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) ISK_Channel PF02060.15 EKE37177.1 - 0.14 11.9 1.9 5.7 6.7 0.1 2.4 2 0 0 2 2 2 0 Slow voltage-gated potassium channel Pex24p PF06398.11 EKE37177.1 - 0.28 10.1 5.6 0.07 12.1 1.7 1.7 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin SNARE_assoc PF09335.11 EKE37177.1 - 7.7 7.0 13.3 0.47 11.0 0.6 2.6 2 1 0 2 2 2 0 SNARE associated Golgi protein VSP PF03302.13 EKE37179.1 - 0.00051 19.0 67.3 0.056 12.3 31.4 3.3 1 1 0 2 2 2 2 Giardia variant-specific surface protein DUF2897 PF11446.8 EKE37181.1 - 0.16 11.9 1.2 1.1 9.2 1.2 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) PI3K_C2 PF00792.24 EKE37182.1 - 9.9e-11 41.7 0.1 1.8e-10 40.9 0.1 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 EKE37182.1 - 2.6e-10 40.4 0.0 7e-10 39.0 0.0 1.8 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3Ka PF00613.20 EKE37182.1 - 0.0041 16.6 0.0 0.0066 15.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Psb28 PF03912.14 EKE37183.1 - 0.12 12.6 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 Psb28 protein Sec7 PF01369.20 EKE37184.1 - 1.5e-30 106.3 7.2 3.1e-30 105.2 5.5 2.6 2 0 0 2 2 2 1 Sec7 domain Pkinase PF00069.25 EKE37185.1 - 1.2e-64 218.2 0.0 1.7e-64 217.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37185.1 - 1.9e-43 148.7 0.0 2.7e-43 148.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE37185.1 - 2.4e-17 63.4 0.3 8e-17 61.7 0.0 2.0 2 1 1 3 3 3 1 PH domain PBD PF00786.28 EKE37185.1 - 2.4e-09 37.4 0.0 5.7e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain PH_3 PF14593.6 EKE37185.1 - 2.2e-08 34.1 0.0 5.3e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 EKE37185.1 - 1.8e-05 23.7 0.0 3.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EKE37185.1 - 0.00017 20.6 2.2 0.0026 16.8 2.4 2.0 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EKE37185.1 - 0.016 14.5 0.3 0.69 9.2 0.0 2.4 1 1 0 2 2 2 0 Kinase-like PH_8 PF15409.6 EKE37185.1 - 0.03 14.6 0.0 0.078 13.3 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 EKE37185.1 - 0.039 14.4 0.7 0.78 10.2 0.7 2.6 1 1 0 1 1 1 0 Pleckstrin homology domain GatB_Yqey PF02637.18 EKE37187.1 - 0.05 13.5 0.2 0.079 12.8 0.2 1.5 1 1 0 1 1 1 0 GatB domain HA2 PF04408.23 EKE37189.1 - 5.6e-19 68.4 0.0 2.3e-18 66.5 0.0 2.0 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EKE37189.1 - 4.1e-17 62.3 0.0 8.8e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EKE37189.1 - 9e-12 45.3 0.0 2.8e-11 43.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EKE37189.1 - 4e-07 30.0 0.0 9.8e-07 28.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 EKE37189.1 - 3.1e-05 23.2 0.0 5.9e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EKE37189.1 - 4.6e-05 23.7 0.2 0.00029 21.1 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 EKE37189.1 - 0.0027 18.0 0.0 0.0071 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EKE37189.1 - 0.03 14.1 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EKE37189.1 - 0.03 13.8 0.0 0.09 12.2 0.0 1.8 1 0 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 EKE37189.1 - 0.039 13.3 0.6 0.13 11.6 0.1 2.1 1 1 1 2 2 2 0 KaiC AAA_23 PF13476.6 EKE37189.1 - 0.15 12.5 0.2 0.15 12.5 0.2 3.5 1 1 2 3 3 1 0 AAA domain cobW PF02492.19 EKE37189.1 - 0.16 11.5 0.2 5.2 6.6 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EKE37189.1 - 0.28 11.7 0.1 0.28 11.7 0.1 2.7 1 1 1 2 2 2 0 ABC transporter FtsK_SpoIIIE PF01580.18 EKE37189.1 - 0.35 10.2 1.4 1.6 8.1 0.0 2.5 3 0 0 3 3 3 0 FtsK/SpoIIIE family ORC4_C PF14629.6 EKE37190.1 - 0.013 14.9 0.1 0.023 14.1 0.1 1.3 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus DUF3899 PF13038.6 EKE37190.1 - 0.055 14.0 0.2 0.29 11.7 0.2 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) ETRAMP PF09716.10 EKE37190.1 - 0.14 12.2 2.4 3.8 7.6 0.1 2.9 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Peptidase_M48_N PF16491.5 EKE37190.1 - 0.24 11.2 4.9 0.7 9.8 4.9 1.7 1 1 0 1 1 1 0 CAAX prenyl protease N-terminal, five membrane helices XPG_N PF00752.17 EKE37191.1 - 3.1e-28 98.2 0.0 8.9e-28 96.7 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EKE37191.1 - 2e-27 95.4 0.2 6.6e-27 93.7 0.2 1.9 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EKE37191.1 - 2.1e-07 31.4 3.5 4.9e-07 30.3 0.0 2.8 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.16 EKE37191.1 - 3.5e-05 23.8 0.0 0.00011 22.2 0.0 1.8 1 1 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain HHH_2 PF12826.7 EKE37191.1 - 0.00081 19.4 0.2 0.037 14.1 0.0 3.1 3 0 0 3 3 3 1 Helix-hairpin-helix motif PAPA-1 PF04795.12 EKE37191.1 - 0.031 15.1 4.5 0.031 15.1 4.5 2.9 3 1 0 3 3 3 0 PAPA-1-like conserved region DUF892 PF05974.12 EKE37191.1 - 0.1 12.6 3.5 0.21 11.6 3.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF892) DUF2004 PF09406.10 EKE37191.1 - 0.12 12.7 1.5 0.33 11.3 0.4 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2004) HemY_N PF07219.13 EKE37191.1 - 0.24 11.6 1.6 0.51 10.6 1.6 1.5 1 0 0 1 1 1 0 HemY protein N-terminus DUF4878 PF12870.7 EKE37191.1 - 0.36 11.2 6.5 0.2 12.0 0.3 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4878) M16C_assoc PF08367.11 EKE37191.1 - 0.91 8.6 6.1 1.7 7.7 6.1 1.4 1 0 0 1 1 1 0 Peptidase M16C associated CSTF2_hinge PF14327.6 EKE37191.1 - 1.3 9.5 4.1 2.3 8.7 2.7 2.0 2 0 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 EMC3_TMCO1 PF01956.16 EKE37191.1 - 9.2 6.0 10.5 0.62 9.8 4.9 1.8 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF4363 PF14276.6 EKE37191.1 - 9.7 6.4 8.3 6.7 6.9 2.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) Sas10 PF09368.10 EKE37192.1 - 1e-05 25.9 9.0 1e-05 25.9 9.0 2.6 2 1 0 2 2 2 1 Sas10 C-terminal domain Ribosomal_S8e PF01201.22 EKE37193.1 - 1.1e-45 155.2 3.9 1.5e-45 154.7 3.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e CFAP91 PF14738.6 EKE37193.1 - 0.89 9.6 6.9 1.2 9.2 3.6 2.1 2 0 0 2 2 2 0 Cilia- and flagella-associated protein 91 Shisa PF13908.6 EKE37194.1 - 8 6.7 5.8 4.9 7.4 0.9 2.1 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator His_Phos_2 PF00328.22 EKE37197.1 - 0.028 13.8 0.6 0.032 13.6 0.6 1.1 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) Aldo_ket_red PF00248.21 EKE37197.1 - 0.046 12.9 0.4 0.067 12.4 0.3 1.3 1 1 0 1 1 1 0 Aldo/keto reductase family GramPos_pilinD3 PF16570.5 EKE37198.1 - 0.074 13.8 0.1 0.17 12.6 0.1 1.5 1 0 0 1 1 1 0 Gram-positive pilin backbone subunit 3, Cna-B-like domain DUF2575 PF10837.8 EKE37199.1 - 0.052 13.9 1.1 10 6.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2575) Kelch_1 PF01344.25 EKE37199.1 - 0.44 10.2 1.9 0.44 10.2 0.2 1.9 2 0 0 2 2 2 0 Kelch motif TPR_2 PF07719.17 EKE37200.1 - 2.7e-17 61.4 0.4 3.4e-05 23.6 0.0 3.8 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EKE37200.1 - 4.3e-17 61.1 6.0 5.7e-06 25.9 0.0 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EKE37200.1 - 3.7e-11 42.3 2.7 0.00014 21.8 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKE37200.1 - 2.6e-08 33.4 5.1 0.0046 16.6 0.9 3.3 2 1 1 3 3 3 2 TPR repeat TPR_12 PF13424.6 EKE37200.1 - 9.1e-07 29.1 0.1 0.11 12.8 0.0 3.2 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EKE37200.1 - 1.1e-06 28.5 0.3 0.016 15.5 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EKE37200.1 - 3.6e-06 27.3 0.0 0.013 16.3 0.0 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EKE37200.1 - 2.1e-05 24.9 0.0 0.00012 22.5 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EKE37200.1 - 3.7e-05 24.3 0.0 0.011 16.4 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EKE37200.1 - 0.00014 22.2 0.4 0.088 13.5 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EKE37200.1 - 0.00037 20.3 0.2 0.21 11.7 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EKE37200.1 - 0.0009 19.3 0.0 0.0016 18.6 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE37200.1 - 0.00095 19.3 0.2 0.0018 18.4 0.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EKE37200.1 - 0.016 15.1 0.1 2.3 8.2 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3949 PF13133.6 EKE37200.1 - 0.027 14.9 0.8 0.08 13.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3949) Fis1_TPR_C PF14853.6 EKE37200.1 - 0.03 14.4 0.8 19 5.4 0.0 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EKE37200.1 - 1.2 9.2 8.7 3.6 7.7 0.0 4.1 5 1 1 6 6 6 0 MIT (microtubule interacting and transport) domain ATP-synt_E_2 PF08112.11 EKE37200.1 - 5.2 7.4 12.9 4.6 7.6 3.8 3.3 1 1 2 3 3 3 0 ATP synthase epsilon subunit DSPc PF00782.20 EKE37201.1 - 8.3e-06 25.6 0.1 2.2e-05 24.3 0.0 1.7 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EKE37201.1 - 0.00062 19.4 0.0 0.00086 18.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EKE37201.1 - 0.063 13.4 0.0 0.11 12.6 0.0 1.5 1 1 0 1 1 1 0 Inositol hexakisphosphate Ribosomal_S30 PF04758.14 EKE37202.1 - 3.9e-23 81.4 4.0 4.4e-23 81.2 4.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 ERCC3_RAD25_C PF16203.5 EKE37204.1 - 8.8e-73 244.5 1.3 1.7e-72 243.6 1.3 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EKE37204.1 - 4.6e-23 81.7 0.0 9.7e-23 80.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE37204.1 - 1.2e-19 70.9 3.0 4.1e-19 69.2 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EKE37204.1 - 1.6e-17 63.8 4.5 1.8e-17 63.7 0.0 3.2 4 1 0 4 4 4 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EKE37204.1 - 3.3e-11 42.5 0.5 1.2e-09 37.4 0.3 2.4 1 1 1 2 2 2 1 SNF2 family N-terminal domain DEAD PF00270.29 EKE37204.1 - 1.8e-05 24.6 0.9 0.00011 22.0 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase AsnC_trans_reg2 PF17805.1 EKE37204.1 - 0.0054 16.9 0.0 0.024 14.8 0.0 2.2 2 0 0 2 2 2 1 AsnC-like ligand binding domain BOFC_N PF08977.10 EKE37204.1 - 0.049 13.6 0.1 0.22 11.5 0.0 2.2 2 0 0 2 2 2 0 Bypass of Forespore C, N terminal TraD_N PF12615.8 EKE37204.1 - 0.076 13.8 0.3 45 4.9 0.0 3.4 3 0 0 3 3 3 0 F sex factor protein N terminal Flu_B_M2 PF04772.12 EKE37204.1 - 0.11 12.8 0.1 0.61 10.4 0.0 2.3 2 1 0 2 2 2 0 Influenza B matrix protein 2 (BM2) CNP_C_terminal PF17839.1 EKE37204.1 - 1.5 9.6 6.0 2.8 8.7 4.9 2.2 1 1 0 1 1 1 0 C-terminal domain of cyclic nucleotide phosphodiesterase Pkinase PF00069.25 EKE37205.1 - 2.2e-50 171.5 0.1 2.6e-50 171.2 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37205.1 - 5.9e-50 170.0 0.0 6.9e-50 169.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37205.1 - 3.8e-06 25.9 0.0 4.8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE37205.1 - 0.0003 20.2 0.0 0.0004 19.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EKE37205.1 - 0.041 13.4 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 EKE37205.1 - 0.12 12.0 0.5 4.6 6.8 0.1 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Exo_endo_phos PF03372.23 EKE37206.1 - 9.9e-06 25.2 0.0 1.5e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Tox-GHH2 PF15635.6 EKE37206.1 - 0.0035 17.8 0.0 0.022 15.3 0.0 2.3 3 0 0 3 3 3 1 GHH signature containing HNH/Endo VII superfamily nuclease toxin 2 HAD_2 PF13419.6 EKE37207.1 - 4.7e-27 95.2 0.5 5.6e-27 95.0 0.5 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKE37207.1 - 4.9e-12 46.6 0.3 5.6e-11 43.1 0.3 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EKE37207.1 - 5.3e-05 23.3 0.1 0.0039 17.3 0.0 2.3 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EKE37207.1 - 0.00016 22.2 0.0 0.00023 21.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 EKE37207.1 - 0.0046 16.8 0.3 0.15 11.9 0.3 2.3 1 1 0 1 1 1 1 Acid Phosphatase Hydrolase_3 PF08282.12 EKE37207.1 - 0.04 13.7 1.0 0.33 10.7 0.1 2.2 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Acetyltransf_3 PF13302.7 EKE37208.1 - 4.2e-17 63.1 0.0 4.9e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EKE37208.1 - 1.6e-07 31.6 0.0 1.9e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EKE37208.1 - 1.1e-06 28.8 0.6 1.3e-06 28.6 0.6 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EKE37208.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 EKE37209.1 - 1.9e-67 227.4 0.1 2.2e-67 227.2 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37209.1 - 4.8e-34 117.8 0.2 6.4e-34 117.4 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE37209.1 - 5.6e-08 32.4 0.0 7.3e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKE37209.1 - 0.0015 17.9 0.1 0.002 17.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKE37209.1 - 0.013 14.4 0.0 0.022 13.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EKE37209.1 - 0.072 13.0 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sigma_reg_N PF13800.6 EKE37210.1 - 0.44 10.9 4.8 4.5 7.6 0.6 2.6 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Aldedh PF00171.22 EKE37211.1 - 7.3e-86 288.5 0.0 9e-86 288.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family tRNA-synt_1b PF00579.25 EKE37212.1 - 5.2e-50 170.4 0.3 1.7e-49 168.7 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (W and Y) Pyridoxal_deC PF00282.19 EKE37212.1 - 3.5e-26 91.8 0.0 2.1e-25 89.2 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain OKR_DC_1 PF01276.20 EKE37212.1 - 0.00069 18.5 0.0 0.0011 17.8 0.0 1.2 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Beta_elim_lyase PF01212.21 EKE37212.1 - 0.093 12.0 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase DUF5105 PF17118.5 EKE37212.1 - 2.2 8.1 7.5 16 5.2 1.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5105) SRI PF08236.11 EKE37212.1 - 3.9 7.7 7.3 39 4.5 0.1 4.1 3 0 0 3 3 3 0 SRI (Set2 Rpb1 interacting) domain Thioredoxin PF00085.20 EKE37213.1 - 0.014 15.4 0.3 0.15 12.1 0.0 2.9 4 0 0 4 4 4 0 Thioredoxin DUF5504 PF17608.2 EKE37213.1 - 0.12 12.5 0.2 0.24 11.5 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5504) SDA1 PF05285.12 EKE37214.1 - 0.031 13.7 13.9 0.042 13.3 13.9 1.1 1 0 0 1 1 1 0 SDA1 DUF1963 PF09234.10 EKE37214.1 - 0.05 14.1 1.7 0.077 13.5 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1963) CDC45 PF02724.14 EKE37214.1 - 6.3 5.0 10.1 8.6 4.5 10.1 1.1 1 0 0 1 1 1 0 CDC45-like protein RRM_1 PF00076.22 EKE37216.1 - 1.1e-07 31.6 0.0 2.7e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF3g PF12353.8 EKE37216.1 - 7.9e-06 26.3 0.7 2.9e-05 24.5 0.7 1.9 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G DUF4898 PF16239.5 EKE37216.1 - 0.0048 16.8 4.0 0.29 11.1 0.3 3.0 3 0 0 3 3 3 2 Domain of unknown function (DUF4898) zf-CCHC_3 PF13917.6 EKE37216.1 - 0.019 14.9 0.2 0.032 14.2 0.2 1.3 1 0 0 1 1 1 0 Zinc knuckle C1_2 PF03107.16 EKE37216.1 - 0.072 13.4 0.2 0.13 12.6 0.2 1.4 1 0 0 1 1 1 0 C1 domain zf-CCHC PF00098.23 EKE37216.1 - 0.12 12.5 2.6 0.21 11.7 2.6 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 EKE37216.1 - 0.2 11.5 3.8 0.37 10.7 3.8 1.4 1 0 0 1 1 1 0 Zinc knuckle DUF2106 PF09879.9 EKE37217.1 - 0.16 11.5 0.4 0.23 11.0 0.3 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2106) Nucleoside_tran PF01733.18 EKE37218.1 - 4.4e-09 36.2 16.3 4.4e-09 36.2 16.3 1.5 1 1 0 1 1 1 1 Nucleoside transporter Gaa1 PF04114.14 EKE37218.1 - 8.6e-05 21.7 9.6 8.6e-05 21.7 9.6 2.5 1 1 1 3 3 3 1 Gaa1-like, GPI transamidase component RasGAP PF00616.19 EKE37220.1 - 7.2e-06 25.8 8.2 0.0021 17.8 0.4 2.7 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase Metallophos PF00149.28 EKE37221.1 - 1.7e-29 103.8 0.2 2.6e-29 103.2 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_1 PF00515.28 EKE37221.1 - 2e-19 68.5 7.0 3.1e-06 26.8 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EKE37221.1 - 2.3e-16 58.5 4.8 4.9e-05 23.1 0.5 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EKE37221.1 - 7.3e-12 44.5 6.6 0.00013 21.9 0.5 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 EKE37221.1 - 2.5e-08 33.7 2.1 0.0016 18.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EKE37221.1 - 4.2e-08 33.2 0.1 5.7e-07 29.6 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EKE37221.1 - 5e-08 33.1 0.1 0.013 16.2 0.0 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EKE37221.1 - 6.7e-08 33.1 0.5 0.0078 16.8 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EKE37221.1 - 1.6e-07 31.8 0.8 0.0018 18.7 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EKE37221.1 - 1.7e-06 28.2 3.4 0.0024 18.1 0.2 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKE37221.1 - 4.4e-05 23.1 4.5 0.0071 16.0 0.1 3.5 1 1 2 3 3 3 1 TPR repeat PPP5 PF08321.12 EKE37221.1 - 7.9e-05 22.9 1.3 0.00027 21.2 1.3 2.0 1 0 0 1 1 1 1 PPP5 TPR repeat region NARP1 PF12569.8 EKE37221.1 - 8.1e-05 21.7 0.1 0.00018 20.6 0.1 1.5 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 EKE37221.1 - 0.00031 21.2 3.7 0.87 10.4 0.4 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EKE37221.1 - 0.00032 20.5 1.4 1 9.6 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EKE37221.1 - 0.018 14.5 0.1 4.9 6.4 0.0 2.2 2 0 0 2 2 2 0 MalT-like TPR region ANAPC3 PF12895.7 EKE37221.1 - 0.018 15.2 1.1 0.018 15.2 1.1 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 GDI PF00996.18 EKE37221.1 - 0.039 12.5 0.2 0.28 9.7 0.1 2.0 1 1 0 2 2 2 0 GDP dissociation inhibitor Fis1_TPR_C PF14853.6 EKE37221.1 - 0.053 13.6 0.3 13 6.0 0.0 2.7 2 1 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Meckelin PF09773.9 EKE37222.1 - 0.0024 16.1 0.5 0.0025 16.0 0.5 1.1 1 0 0 1 1 1 1 Meckelin (Transmembrane protein 67) DUF3583 PF12126.8 EKE37222.1 - 0.12 11.8 2.5 0.11 11.9 1.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3583) DUF2254 PF10011.9 EKE37222.1 - 5.7 5.7 7.3 7.4 5.3 7.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) DPM3 PF08285.11 EKE37223.1 - 8.4 6.7 6.4 1.4 9.1 1.3 2.2 2 1 1 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) CUB PF00431.20 EKE37224.1 - 0.2 12.0 2.1 8.5 6.8 0.9 2.3 2 0 0 2 2 2 0 CUB domain CK_II_beta PF01214.18 EKE37225.1 - 1.1e-58 198.0 2.5 1.3e-58 197.8 2.5 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit PP2C PF00481.21 EKE37226.1 - 8.6e-35 120.6 0.1 1.5e-34 119.8 0.1 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE37226.1 - 4.3e-05 23.3 0.5 7.5e-05 22.5 0.0 1.5 2 0 0 2 2 2 1 Protein phosphatase 2C YxiJ PF14176.6 EKE37226.1 - 0.097 13.2 1.2 0.28 11.7 1.2 1.7 1 0 0 1 1 1 0 YxiJ-like protein Peptidase_M48_N PF16491.5 EKE37227.1 - 3.2e-35 121.7 17.8 3.2e-35 121.7 17.8 1.8 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EKE37227.1 - 1.9e-32 112.6 0.9 2.2e-32 112.4 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M48 FokI_N PF02981.15 EKE37228.1 - 0.1 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Restriction endonuclease FokI, recognition domain Tetraspanin PF00335.20 EKE37230.1 - 8.3e-10 38.8 21.6 6.4e-09 35.9 21.6 2.0 1 1 0 1 1 1 1 Tetraspanin family Rhomboid PF01694.22 EKE37230.1 - 0.0018 18.3 7.6 0.0018 18.3 7.6 1.8 2 0 0 2 2 2 1 Rhomboid family TMEM132D_C PF15706.5 EKE37230.1 - 0.0018 18.0 1.0 0.017 14.9 0.1 2.3 2 0 0 2 2 2 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Fibrillin_U_N PF18193.1 EKE37230.1 - 0.12 12.5 0.4 0.21 11.7 0.4 1.3 1 0 0 1 1 1 0 Fibrillin 1 unique N-terminal domain COX4 PF02936.14 EKE37230.1 - 0.16 12.0 0.0 0.16 12.0 0.0 2.1 3 0 0 3 3 3 0 Cytochrome c oxidase subunit IV DUF373 PF04123.13 EKE37230.1 - 3.3 7.1 11.0 5.7 6.3 11.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF373) DUF4064 PF13273.6 EKE37230.1 - 4.8 7.5 18.9 0.15 12.3 9.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) CK_II_beta PF01214.18 EKE37231.1 - 1.4e-67 227.1 0.7 1.6e-67 226.9 0.7 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Gly_transf_sug PF04488.15 EKE37233.1 - 0.077 13.6 0.7 0.4 11.4 0.2 2.2 2 0 0 2 2 2 0 Glycosyltransferase sugar-binding region containing DXD motif Dopey_N PF04118.14 EKE37234.1 - 1.2e-45 155.9 0.1 1.6e-45 155.6 0.1 1.0 1 0 0 1 1 1 1 Dopey, N-terminal DUF5311 PF17238.2 EKE37234.1 - 0.032 14.1 0.7 0.21 11.5 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5311) RE_AlwI PF09491.10 EKE37234.1 - 0.033 13.0 4.9 0.02 13.7 1.7 1.8 2 0 0 2 2 2 0 AlwI restriction endonuclease BRCT_3 PF18428.1 EKE37236.1 - 0.0049 16.9 0.1 0.013 15.6 0.1 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain SoxY PF13501.6 EKE37236.1 - 0.076 13.2 0.2 0.15 12.3 0.2 1.5 1 0 0 1 1 1 0 Sulfur oxidation protein SoxY BRCT PF00533.26 EKE37236.1 - 0.14 12.6 2.7 0.21 12.0 0.6 2.5 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain ATPase-cat_bd PF12156.8 EKE37236.1 - 0.2 12.4 3.7 0.78 10.5 0.6 2.7 2 1 1 3 3 3 0 Putative metal-binding domain of cation transport ATPase Fe_hyd_lg_C PF02906.14 EKE37237.1 - 6.9e-70 235.5 1.7 9.3e-70 235.0 1.7 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fer4 PF00037.27 EKE37237.1 - 9.1e-12 44.3 8.0 1.7e-05 24.4 0.7 3.0 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EKE37237.1 - 1.1e-07 32.3 19.3 2.6e-06 27.9 10.2 3.4 3 2 1 4 4 4 2 4Fe-4S dicluster domain Fer4_15 PF13459.6 EKE37237.1 - 3e-07 31.1 3.4 0.017 15.9 0.1 3.2 3 0 0 3 3 2 2 4Fe-4S single cluster domain Fer4_6 PF12837.7 EKE37237.1 - 7.3e-07 29.0 5.4 0.0056 16.7 0.7 3.0 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 EKE37237.1 - 8.3e-07 29.1 6.7 8.3e-07 29.1 6.7 2.6 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fe_hyd_SSU PF02256.17 EKE37237.1 - 2.8e-06 27.3 0.1 5.7e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 Iron hydrogenase small subunit Fer4_8 PF13183.6 EKE37237.1 - 8.2e-06 26.2 5.6 5.5e-05 23.5 5.9 2.4 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 EKE37237.1 - 9.7e-06 26.0 6.4 5.1e-05 23.7 6.5 2.3 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 EKE37237.1 - 1.7e-05 24.8 9.8 0.0022 18.1 0.3 3.2 3 0 0 3 3 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EKE37237.1 - 3.1e-05 23.8 13.3 0.011 15.7 0.8 3.5 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 EKE37237.1 - 0.00013 22.0 7.9 0.00013 22.0 7.9 2.9 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 EKE37237.1 - 0.00064 20.6 6.5 0.00064 20.6 6.5 2.7 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain Fer4_22 PF17179.4 EKE37237.1 - 0.036 14.9 15.9 0.18 12.7 1.1 3.4 4 0 0 4 4 3 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 EKE37237.1 - 9.5 6.5 9.8 3.9 7.7 0.3 3.0 3 0 0 3 3 3 0 4Fe-4S dicluster domain Pro_CA PF00484.19 EKE37238.1 - 2.4e-32 112.4 0.9 3.4e-32 111.9 0.9 1.2 1 0 0 1 1 1 1 Carbonic anhydrase PAP2 PF01569.21 EKE37239.1 - 2.9e-25 88.6 2.3 2.9e-25 88.6 2.3 1.6 2 0 0 2 2 2 1 PAP2 superfamily NCE101 PF11654.8 EKE37239.1 - 0.098 12.4 0.1 0.36 10.6 0.0 2.0 2 0 0 2 2 2 0 Non-classical export protein 1 PAP2_3 PF14378.6 EKE37239.1 - 5.3 6.7 8.3 94 2.6 8.3 2.6 1 1 0 1 1 1 0 PAP2 superfamily YhhN PF07947.14 EKE37240.1 - 2.8e-22 79.2 22.7 3.6e-22 78.9 22.7 1.2 1 0 0 1 1 1 1 YhhN family Phage_holin_5_2 PF16079.5 EKE37240.1 - 4 7.8 14.7 5 7.5 1.7 3.9 2 2 2 4 4 4 0 Phage holin family Hol44, in holin superfamily V DUF962 PF06127.11 EKE37240.1 - 9.4 6.4 9.5 0.46 10.6 0.4 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF962) HAD_2 PF13419.6 EKE37241.1 - 2.1e-25 89.8 0.2 4e-25 88.9 0.1 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKE37241.1 - 1.1e-13 52.0 0.0 2.1e-13 51.0 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EKE37241.1 - 5e-05 23.3 0.0 7.9e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EKE37241.1 - 0.0011 19.4 0.0 0.0018 18.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase zf-C3HC4_3 PF13920.6 EKE37242.1 - 2.5e-10 40.0 8.8 6.8e-10 38.7 8.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE37242.1 - 9.9e-10 38.1 11.0 2.9e-09 36.6 11.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE37242.1 - 2.2e-09 37.5 10.8 2.2e-09 37.5 10.8 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EKE37242.1 - 4.4e-08 33.0 7.0 4.4e-08 33.0 7.0 2.3 2 1 1 3 3 3 1 RING-type zinc-finger zf-rbx1 PF12678.7 EKE37242.1 - 1.6e-07 31.5 5.7 1.6e-07 31.5 5.7 2.3 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EKE37242.1 - 3.7e-07 29.9 10.6 3.7e-07 29.9 10.6 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EKE37242.1 - 3e-06 27.3 7.1 3e-06 27.3 7.1 2.6 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EKE37242.1 - 1.4e-05 24.9 7.8 3.2e-05 23.7 7.8 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EKE37242.1 - 7.8e-05 22.6 7.9 0.00026 20.9 7.9 2.0 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EKE37242.1 - 0.067 12.8 5.5 0.15 11.7 5.5 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_10 PF16685.5 EKE37242.1 - 0.069 13.3 7.5 0.045 13.9 4.4 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-Nse PF11789.8 EKE37242.1 - 0.076 12.8 5.2 0.21 11.5 5.2 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 EKE37242.1 - 0.46 10.6 10.3 0.045 13.8 5.1 2.0 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Ank_2 PF12796.7 EKE37243.1 - 5.3e-13 49.4 0.8 5.4e-06 26.9 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Patatin PF01734.22 EKE37243.1 - 1.4e-10 41.7 0.0 4.2e-09 36.9 0.1 2.9 1 1 1 2 2 2 1 Patatin-like phospholipase Ank_4 PF13637.6 EKE37243.1 - 3e-10 40.4 1.3 0.0048 17.5 0.0 4.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE37243.1 - 5.9e-09 36.0 0.2 9.4e-06 25.8 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EKE37243.1 - 1.1e-07 32.0 2.9 0.0022 18.4 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EKE37243.1 - 2e-07 30.8 4.6 0.0098 16.3 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeat GAT PF03127.14 EKE37243.1 - 6.3 7.2 8.1 0.66 10.3 0.2 2.9 3 0 0 3 3 3 0 GAT domain GerPC PF10737.9 EKE37244.1 - 0.012 15.6 9.4 0.06 13.4 3.5 2.2 1 1 1 2 2 2 0 Spore germination protein GerPC EFG_IV PF03764.18 EKE37244.1 - 0.039 13.7 6.0 0.38 10.5 2.8 2.9 1 1 1 2 2 2 0 Elongation factor G, domain IV zf_CopZ PF18423.1 EKE37245.1 - 0.014 15.3 0.9 0.047 13.6 0.9 1.9 1 0 0 1 1 1 0 Zinc binding domain PFO_beta_C PF12367.8 EKE37245.1 - 0.077 13.1 0.8 0.26 11.5 0.1 2.3 2 0 0 2 2 2 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal DnaJ-X PF14308.6 EKE37245.1 - 0.23 10.9 6.6 0.43 10.0 6.6 1.4 1 0 0 1 1 1 0 X-domain of DnaJ-containing Suf PF05843.14 EKE37246.1 - 2.5e-07 31.0 32.2 0.015 15.3 3.1 5.8 6 1 1 7 7 7 4 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EKE37246.1 - 6.2e-05 23.4 0.0 0.014 15.9 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EKE37246.1 - 0.00042 20.9 0.0 19 6.4 0.0 5.4 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 EKE37246.1 - 0.099 11.8 1.3 5 6.2 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR_2 PF13041.6 EKE37246.1 - 0.14 12.3 0.2 0.14 12.3 0.2 4.3 5 0 0 5 5 5 0 PPR repeat family PPR PF01535.20 EKE37246.1 - 0.23 11.8 3.7 2.2 8.7 0.1 4.6 6 1 0 6 6 6 0 PPR repeat TPR_2 PF07719.17 EKE37246.1 - 0.3 11.3 1.7 45 4.5 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Imm6 PF14434.6 EKE37247.1 - 0.0022 17.9 6.0 0.0027 17.6 0.9 3.8 3 0 0 3 3 3 1 Immunity protein Imm6 ACP53EA PF06313.11 EKE37247.1 - 0.16 12.2 5.6 1.5 9.1 0.1 4.2 3 1 0 3 3 3 0 Drosophila ACP53EA protein DarA_C PF18789.1 EKE37249.1 - 0.1 12.9 0.3 0.79 10.1 0.0 2.2 2 0 0 2 2 2 0 Defence against restriction A C-terminal Ribosomal_60s PF00428.19 EKE37252.1 - 1e-19 70.9 8.5 1.3e-19 70.5 8.5 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein Pkinase PF00069.25 EKE37253.1 - 8.1e-52 176.2 0.3 1.2e-51 175.6 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37253.1 - 2.7e-18 66.2 0.0 3.6e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EKE37253.1 - 0.0066 16.1 0.0 0.015 14.9 0.0 1.5 1 1 0 1 1 1 1 RIO1 family Na_Ca_ex_C PF16494.5 EKE37253.1 - 0.15 12.5 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain Snapin_Pallidin PF14712.6 EKE37254.1 - 2.7e-13 50.1 1.8 2.7e-13 50.1 1.8 2.0 1 1 1 2 2 2 1 Snapin/Pallidin CLIP1_ZNF PF16641.5 EKE37255.1 - 5.9e-06 26.0 16.5 2.1e-05 24.2 8.6 2.5 2 0 0 2 2 2 2 CLIP1 zinc knuckle zf-CCHC_3 PF13917.6 EKE37255.1 - 0.00025 20.9 0.6 0.00025 20.9 0.6 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 EKE37255.1 - 0.0013 18.7 16.1 0.017 15.2 2.9 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 EKE37255.1 - 0.049 13.5 11.3 0.26 11.2 4.0 2.8 2 0 0 2 2 2 0 Zinc knuckle DNA_pol3_a_NI PF14480.6 EKE37255.1 - 0.076 13.0 3.1 0.078 13.0 1.7 1.8 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus I Myotub-related PF06602.14 EKE37257.1 - 1.2e-95 320.4 0.0 1.9e-95 319.8 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain RA PF00788.23 EKE37257.1 - 0.017 15.8 0.4 4.4 8.0 0.0 3.1 3 0 0 3 3 3 0 Ras association (RalGDS/AF-6) domain Y_phosphatase3 PF13350.6 EKE37257.1 - 0.03 14.3 0.0 0.053 13.5 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 EKE37257.1 - 0.037 13.6 0.0 0.072 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPc PF00782.20 EKE37257.1 - 0.054 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain RabGAP-TBC PF00566.18 EKE37259.1 - 3.8e-07 30.0 6.6 1.2e-06 28.3 4.1 2.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 EKE37259.1 - 0.00098 19.6 0.2 0.0043 17.6 0.2 1.9 1 1 0 1 1 1 1 Rhodanese-like domain Metallophos PF00149.28 EKE37260.1 - 5e-12 46.7 2.1 1.3e-11 45.4 2.1 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE37260.1 - 2e-07 31.4 0.0 3.1e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EKE37260.1 - 3.5e-05 23.3 0.0 0.00035 20.0 0.0 2.0 2 0 0 2 2 2 1 Metallophosphoesterase, calcineurin superfamily RhoGAP PF00620.27 EKE37261.1 - 3.7e-20 72.3 0.4 2.5e-19 69.6 0.0 2.4 3 0 0 3 3 3 1 RhoGAP domain DUF3614 PF12267.8 EKE37261.1 - 0.3 11.6 4.7 0.61 10.6 4.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3614) Mod_r PF07200.13 EKE37261.1 - 7.6 6.6 14.9 0.89 9.7 4.0 2.8 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Pkinase PF00069.25 EKE37262.1 - 1.1e-65 221.6 1.5 3.4e-65 220.1 0.1 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37262.1 - 7e-48 163.2 0.0 1.1e-47 162.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EKE37262.1 - 8.5e-06 24.9 3.4 1e-05 24.7 0.4 2.4 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EKE37262.1 - 0.00089 18.6 0.1 0.006 15.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EKE37262.1 - 0.0015 17.4 1.3 0.0035 16.2 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 EKE37262.1 - 0.17 11.7 0.0 12 5.7 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family LRRC37AB_C PF14914.6 EKE37262.1 - 0.56 10.1 4.5 0.81 9.6 0.1 2.5 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain TORC_N PF12884.7 EKE37262.1 - 2.3 9.0 12.2 0.12 13.1 3.7 2.8 3 0 0 3 3 3 0 Transducer of regulated CREB activity, N terminus PocR PF10114.9 EKE37262.1 - 8.1 6.2 8.0 2.4 7.9 0.0 3.0 3 0 0 3 3 3 0 Sensory domain found in PocR LMSTEN PF07988.12 EKE37263.1 - 0.13 11.8 0.4 0.26 10.8 0.0 1.7 2 0 0 2 2 2 0 LMSTEN motif UBA_4 PF14555.6 EKE37264.1 - 0.00026 20.7 0.0 0.00064 19.5 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain SLD5_C PF16922.5 EKE37265.1 - 3.8e-14 52.6 0.0 6.4e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Baculo_PEP_C PF04513.12 EKE37266.1 - 0.076 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Stap_Strp_tox_C PF02876.17 EKE37266.1 - 0.54 10.6 5.6 0.23 11.8 0.6 2.6 2 2 0 2 2 2 0 Staphylococcal/Streptococcal toxin, beta-grasp domain Endotoxin_C2 PF18449.1 EKE37266.1 - 5.7 7.4 7.6 4.8 7.6 1.7 2.9 3 0 0 3 3 3 0 Delta endotoxin ABC2_membrane_5 PF13346.6 EKE37267.1 - 0.0072 15.9 1.3 0.0097 15.5 1.3 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein Shisa PF13908.6 EKE37267.1 - 0.049 13.9 0.2 0.049 13.9 0.2 1.5 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator EbsA PF17255.2 EKE37267.1 - 0.062 13.6 0.7 0.083 13.2 0.2 1.5 2 0 0 2 2 2 0 EbsA-like protein RRM_1 PF00076.22 EKE37268.1 - 1.3e-11 44.1 0.0 2.4e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKE37268.1 - 0.039 13.5 0.0 0.049 13.2 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mto2_bdg PF12808.7 EKE37268.1 - 0.37 11.1 7.1 5.2 7.5 0.8 2.3 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Autophagy_act_C PF03987.15 EKE37269.1 - 6.6e-10 39.4 2.1 1.4e-09 38.4 0.2 2.4 3 0 0 3 3 3 1 Autophagocytosis associated protein, active-site domain DUF4258 PF14076.6 EKE37270.1 - 2.7 8.4 11.5 0.38 11.2 1.3 4.3 4 1 0 4 4 4 0 Domain of unknown function (DUF4258) Pkinase_Tyr PF07714.17 EKE37272.1 - 5.1e-49 166.9 0.0 7.9e-49 166.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37272.1 - 9.9e-39 133.3 0.0 1.7e-38 132.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Oxidored_nitro PF00148.19 EKE37272.1 - 0.058 12.1 0.0 0.089 11.5 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase Ribonuclease_3 PF00636.26 EKE37274.1 - 0.0041 17.7 0.2 0.13 12.8 0.2 3.0 1 1 0 1 1 1 1 Ribonuclease III domain V-ATPase_H_C PF11698.8 EKE37275.1 - 4.7e-36 123.4 0.0 1.6e-35 121.7 0.0 2.0 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 EKE37275.1 - 2.1e-20 73.3 11.5 2.9e-20 72.8 11.5 1.1 1 0 0 1 1 1 1 V-ATPase subunit H DUF2428 PF10350.9 EKE37275.1 - 0.054 12.7 0.1 0.24 10.6 0.0 2.0 2 0 0 2 2 2 0 Putative death-receptor fusion protein (DUF2428) Acetyltransf_1 PF00583.25 EKE37276.1 - 1.9e-13 50.6 0.1 2.3e-13 50.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EKE37276.1 - 6.3e-08 32.6 0.1 2.8e-07 30.5 0.1 1.7 1 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EKE37276.1 - 2e-06 28.2 1.1 3.1e-06 27.5 1.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EKE37276.1 - 0.089 12.9 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DENN PF02141.21 EKE37277.1 - 5e-18 65.7 7.5 1.4e-17 64.2 3.8 3.0 2 1 0 2 2 2 1 DENN (AEX-3) domain TLD PF07534.16 EKE37278.1 - 0.00012 22.3 2.6 0.001 19.3 0.0 3.0 3 0 0 3 3 3 1 TLD F_actin_bund_C PF18060.1 EKE37280.1 - 1.1e-21 76.7 10.5 2.6e-21 75.5 10.5 1.7 1 0 0 1 1 1 1 F actin bundling C terminal TraC PF07820.12 EKE37280.1 - 0.0012 19.2 1.1 0.0029 17.9 1.1 1.6 1 0 0 1 1 1 1 TraC-like protein DUF4349 PF14257.6 EKE37280.1 - 0.003 17.0 1.7 0.0042 16.6 1.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) AAA_13 PF13166.6 EKE37280.1 - 0.018 13.7 4.3 0.021 13.5 4.3 1.1 1 0 0 1 1 1 0 AAA domain ABC_tran_CTD PF16326.5 EKE37280.1 - 0.053 13.8 6.5 0.082 13.2 5.3 2.0 1 1 0 1 1 1 0 ABC transporter C-terminal domain GvpL_GvpF PF06386.11 EKE37280.1 - 0.19 11.6 1.3 0.57 10.1 1.1 1.7 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF 60KD_IMP PF02096.20 EKE37280.1 - 0.31 10.9 1.4 0.56 10.1 1.4 1.4 1 0 0 1 1 1 0 60Kd inner membrane protein SlyX PF04102.12 EKE37280.1 - 0.74 10.5 3.9 1.2 9.8 2.3 2.3 1 1 0 1 1 1 0 SlyX BST2 PF16716.5 EKE37280.1 - 0.98 10.0 7.4 0.55 10.8 3.5 2.2 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Ribosomal_L34e PF01199.18 EKE37281.1 - 2.6e-36 123.8 5.9 2.6e-36 123.8 5.9 1.8 2 0 0 2 2 2 1 Ribosomal protein L34e Lar_restr_allev PF14354.6 EKE37281.1 - 0.46 10.9 4.8 1.9 8.9 0.7 2.5 1 1 1 2 2 2 0 Restriction alleviation protein Lar TPR_1 PF00515.28 EKE37282.1 - 9.1e-13 47.4 4.9 0.001 18.8 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EKE37282.1 - 8.2e-10 38.0 1.1 0.078 13.1 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE37282.1 - 3.6e-06 27.1 2.6 9.8e-06 25.7 2.7 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EKE37282.1 - 1.2e-05 25.8 0.2 0.0039 17.7 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EKE37282.1 - 0.00019 21.6 2.5 0.007 16.7 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EKE37282.1 - 0.0059 16.6 0.6 0.078 13.1 0.3 2.5 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 EKE37282.1 - 0.0073 16.6 0.5 1.9 8.8 0.3 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EKE37282.1 - 0.59 10.5 3.5 12 6.4 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Arf PF00025.21 EKE37283.1 - 1.7e-67 226.2 0.0 1.9e-67 226.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE37283.1 - 8.1e-15 54.7 0.0 1e-14 54.4 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EKE37283.1 - 9.8e-14 51.3 0.6 1.5e-10 40.8 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EKE37283.1 - 1.6e-13 50.9 0.0 2.3e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EKE37283.1 - 3.1e-13 49.6 0.0 3.8e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EKE37283.1 - 1.3e-08 34.5 0.0 1.6e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE37283.1 - 0.0029 17.7 0.0 0.0044 17.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EKE37283.1 - 0.042 13.1 0.2 0.068 12.5 0.1 1.3 1 1 0 1 1 1 0 6-phosphofructo-2-kinase AA_permease_2 PF13520.6 EKE37284.1 - 6.1e-25 87.9 49.3 6.1e-25 87.9 49.3 1.5 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EKE37284.1 - 1.6e-09 36.9 48.3 1.7e-09 36.8 47.6 1.3 1 1 0 1 1 1 1 Amino acid permease Hum_adeno_E3A PF05393.11 EKE37284.1 - 0.14 12.1 4.8 0.67 10.0 1.4 2.8 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein FYVE_2 PF02318.16 EKE37285.1 - 0.066 13.4 2.2 0.12 12.6 2.2 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger Zip PF02535.22 EKE37285.1 - 0.15 11.2 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter YabA PF06156.13 EKE37285.1 - 5.8 7.6 12.5 48 4.7 12.5 2.2 1 1 0 1 1 1 0 Initiation control protein YabA FapA PF03961.13 EKE37286.1 - 0.081 11.5 6.2 0.084 11.5 6.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A GPHR_N PF12537.8 EKE37286.1 - 1.8 8.7 3.3 18 5.5 3.3 2.0 1 1 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal Ras PF00071.22 EKE37287.1 - 1.3e-53 180.9 0.3 1.6e-53 180.7 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37287.1 - 5.5e-30 104.1 0.1 9e-30 103.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37287.1 - 4.2e-09 36.1 0.0 4.9e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE37287.1 - 3.9e-08 33.4 0.0 6.6e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE37287.1 - 4.8e-07 29.5 0.0 4.6e-06 26.3 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE37287.1 - 0.0002 20.8 0.1 0.00023 20.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EKE37287.1 - 0.0037 17.0 0.0 0.013 15.3 0.0 1.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EKE37287.1 - 0.0046 16.9 0.0 0.023 14.6 0.0 2.0 2 1 0 2 2 2 1 RsgA GTPase Septin PF00735.18 EKE37287.1 - 0.043 13.1 0.0 0.074 12.3 0.0 1.4 1 0 0 1 1 1 0 Septin SRPRB PF09439.10 EKE37287.1 - 0.07 12.6 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EKE37287.1 - 0.081 13.3 0.0 0.098 13.0 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Ish1 PF10281.9 EKE37287.1 - 0.15 12.4 0.0 0.33 11.3 0.0 1.6 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Ribophorin_I PF04597.14 EKE37288.1 - 1.3e-19 70.7 9.2 2e-19 70.1 9.2 1.2 1 0 0 1 1 1 1 Ribophorin I DDE_1 PF03184.19 EKE37289.1 - 8.2e-09 35.4 1.1 1.5e-08 34.5 1.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease YbaJ PF10757.9 EKE37289.1 - 0.88 10.1 5.6 1.8 9.1 0.1 2.9 2 1 1 3 3 3 0 Biofilm formation regulator YbaJ Cullin PF00888.22 EKE37290.1 - 6.2e-46 157.2 36.4 7.9e-46 156.9 36.4 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EKE37290.1 - 9.6e-17 60.8 6.7 1.1e-15 57.4 1.0 3.9 3 0 0 3 3 3 1 Cullin protein neddylation domain Ribosomal_S25 PF03297.15 EKE37290.1 - 0.66 10.2 6.7 0.39 10.9 2.9 2.6 2 0 0 2 2 2 0 S25 ribosomal protein Lipase_3 PF01764.25 EKE37292.1 - 3.4e-10 39.9 0.0 6e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF2920 PF11144.8 EKE37292.1 - 0.0019 17.5 0.1 0.0041 16.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) Hydrolase_4 PF12146.8 EKE37292.1 - 0.0029 16.9 0.0 0.0041 16.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 EKE37292.1 - 0.0044 16.6 0.2 0.17 11.4 0.1 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF2974) Na_Ca_ex PF01699.24 EKE37292.1 - 0.023 14.7 0.3 0.039 13.9 0.3 1.3 1 0 0 1 1 1 0 Sodium/calcium exchanger protein Thioesterase PF00975.20 EKE37292.1 - 0.028 14.5 0.0 0.044 13.9 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain DUF3089 PF11288.8 EKE37292.1 - 0.03 13.9 0.0 0.67 9.5 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3089) Abhydrolase_3 PF07859.13 EKE37292.1 - 0.034 14.0 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EKE37292.1 - 0.036 13.8 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 EKE37292.1 - 0.058 13.1 0.1 0.17 11.6 0.0 1.7 2 0 0 2 2 2 0 PGAP1-like protein Abhydrolase_6 PF12697.7 EKE37292.1 - 0.085 13.4 0.0 0.11 13.0 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family Acetyltransf_1 PF00583.25 EKE37293.1 - 2.6e-11 43.8 0.0 3.4e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EKE37293.1 - 1.4e-08 35.0 0.0 2.3e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EKE37293.1 - 3.7e-08 33.4 0.1 5.1e-08 32.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EKE37293.1 - 4e-05 23.8 1.3 5.5e-05 23.4 1.3 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EKE37293.1 - 0.00071 20.3 0.0 0.00094 19.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EKE37293.1 - 0.016 15.1 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_18 PF18014.1 EKE37293.1 - 0.022 14.6 0.1 0.19 11.6 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 EKE37293.1 - 0.045 13.5 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ FR47 PF08445.10 EKE37293.1 - 0.06 13.3 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.6 EKE37293.1 - 0.064 13.4 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 EKE37293.1 - 0.17 11.3 4.0 0.33 10.4 1.8 2.1 1 1 1 2 2 2 0 Putative acetyl-transferase Baculo_11_kDa PF06143.11 EKE37294.1 - 0.0069 15.9 5.0 0.04 13.5 1.0 2.7 2 0 0 2 2 2 1 Baculovirus 11 kDa family TadF PF16964.5 EKE37294.1 - 0.045 13.5 0.5 0.045 13.5 0.5 2.0 2 0 0 2 2 2 0 Putative tight adherence pilin protein F MFS_1 PF07690.16 EKE37294.1 - 0.15 10.9 11.2 0.72 8.7 7.5 2.0 2 0 0 2 2 2 0 Major Facilitator Superfamily MRAP PF15183.6 EKE37294.1 - 0.2 11.6 0.3 0.2 11.6 0.3 2.0 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family Chi-conotoxin PF16981.5 EKE37294.1 - 0.4 10.9 0.0 0.4 10.9 0.0 2.7 3 1 0 3 3 3 0 chi-Conotoxin or t superfamily Cytochrom_C_asm PF01578.20 EKE37294.1 - 0.78 9.5 12.6 0.59 9.9 0.5 3.0 2 1 1 3 3 3 0 Cytochrome C assembly protein Ac76 PF05814.11 EKE37294.1 - 4.5 7.3 13.9 0.25 11.4 0.7 2.8 3 0 0 3 3 3 0 Orf76 (Ac76) Pkinase_Tyr PF07714.17 EKE37295.1 - 1e-51 175.7 0.0 1.7e-51 175.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37295.1 - 3.7e-43 147.8 0.0 7.8e-43 146.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE37295.1 - 3.5e-05 22.8 0.1 3.5e-05 22.8 0.1 2.1 2 1 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EKE37295.1 - 0.00066 19.1 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EKE37295.1 - 0.021 14.4 0.1 0.053 13.0 0.1 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF2116 PF09889.9 EKE37296.1 - 0.61 10.1 8.6 1.1 9.2 4.9 2.8 2 1 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) HSP70 PF00012.20 EKE37297.1 - 9.7e-108 360.9 12.1 1.2e-107 360.6 12.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE37297.1 - 1.2e-14 53.9 3.1 2.7e-11 42.9 0.5 3.4 3 0 0 3 3 3 3 MreB/Mbl protein Raco_middle PF17651.1 EKE37297.1 - 0.021 14.5 0.0 0.15 11.7 0.0 2.4 2 0 0 2 2 2 0 RACo middle region DUF5493 PF17597.2 EKE37297.1 - 0.032 14.5 0.0 0.072 13.4 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5493) CAF1A PF12253.8 EKE37298.1 - 1.4 9.1 12.4 0.7 10.1 7.2 2.7 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A PIG-L PF02585.17 EKE37298.1 - 2 9.0 4.6 3.1 8.5 0.1 2.7 1 1 0 2 2 2 0 GlcNAc-PI de-N-acetylase HSP70 PF00012.20 EKE37300.1 - 1.4e-36 125.9 6.0 9.7e-27 93.4 0.0 3.0 3 0 0 3 3 3 3 Hsp70 protein HSP70 PF00012.20 EKE37301.1 - 2.6e-19 68.9 0.0 3.1e-19 68.6 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Pkinase PF00069.25 EKE37302.1 - 2.9e-32 112.1 1.5 2.9e-32 112.1 1.5 2.7 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37302.1 - 1.6e-15 57.1 8.1 2.2e-15 56.7 1.0 3.1 3 1 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE37302.1 - 7.3e-06 25.5 0.9 6.6e-05 22.4 0.0 2.5 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 EKE37302.1 - 0.27 11.1 0.0 0.41 10.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EKE37303.1 - 2.3e-50 171.4 0.1 4.6e-50 170.4 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37303.1 - 3.5e-48 164.1 0.0 1.3e-47 162.2 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase VSP PF03302.13 EKE37303.1 - 3.7e-08 32.7 138.9 3.8e-06 26.0 66.4 4.6 1 1 3 4 4 4 3 Giardia variant-specific surface protein Pkinase_fungal PF17667.1 EKE37303.1 - 4.3e-08 32.3 0.0 6.6e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DKNYY PF13644.6 EKE37303.1 - 0.023 15.5 1.5 0.55 11.0 0.2 3.0 1 1 1 2 2 2 0 DKNYY family PspB PF06667.12 EKE37303.1 - 0.073 13.1 1.1 0.23 11.6 1.1 1.8 1 0 0 1 1 1 0 Phage shock protein B Kdo PF06293.14 EKE37303.1 - 0.2 11.0 0.0 0.39 10.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family bZIP_Maf PF03131.17 EKE37304.1 - 5.5e-18 65.3 8.9 5.5e-18 65.3 8.9 2.1 2 0 0 2 2 2 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EKE37304.1 - 5.1e-07 29.7 8.9 5.1e-07 29.7 8.9 2.8 3 1 1 4 4 4 1 bZIP transcription factor bZIP_2 PF07716.15 EKE37304.1 - 0.0014 18.6 11.2 0.0014 18.6 11.2 2.5 3 1 0 3 3 2 1 Basic region leucine zipper Cdc6_C PF09079.11 EKE37304.1 - 0.029 14.3 0.2 0.057 13.4 0.2 1.6 1 1 0 1 1 1 0 CDC6, C terminal winged helix domain DUF2250 PF10007.9 EKE37304.1 - 0.08 13.1 2.2 0.14 12.3 2.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) DUF2810 PF10928.8 EKE37304.1 - 0.15 12.1 0.2 0.31 11.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2810) DUF4948 PF16306.5 EKE37304.1 - 0.15 11.8 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4948) Topoisom_I_N PF02919.15 EKE37304.1 - 0.21 11.1 4.8 0.29 10.6 4.8 1.2 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Tsg PF04668.12 EKE37304.1 - 0.45 11.2 2.8 0.72 10.5 2.8 1.3 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region Nrap_D6 PF17407.2 EKE37304.1 - 1.1 9.4 6.2 4.1 7.6 2.6 2.1 1 1 1 2 2 2 0 Nrap protein domain 6 TMPIT PF07851.13 EKE37304.1 - 1.5 8.0 4.4 1.9 7.6 4.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein PARG_cat PF05028.14 EKE37305.1 - 2.1e-46 158.8 3.1 3e-46 158.3 3.1 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Ras PF00071.22 EKE37306.1 - 1.3e-42 145.2 0.0 1.7e-42 144.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37306.1 - 5.8e-28 97.5 0.9 1.2e-27 96.6 0.1 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37306.1 - 5.5e-11 42.2 0.0 7.3e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE37306.1 - 4e-05 23.7 0.2 0.00013 22.0 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE37306.1 - 0.00094 19.1 0.2 0.16 11.9 0.1 2.6 2 1 0 2 2 2 1 RsgA GTPase Septin PF00735.18 EKE37306.1 - 0.012 14.9 0.4 0.047 13.0 0.0 1.9 2 1 0 2 2 2 0 Septin AAA_24 PF13479.6 EKE37306.1 - 0.014 15.2 0.0 0.2 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EKE37306.1 - 0.027 14.2 0.7 0.048 13.4 0.1 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 EKE37306.1 - 0.036 14.0 0.3 0.045 13.7 0.3 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea TniB PF05621.11 EKE37306.1 - 0.07 12.5 0.1 0.15 11.5 0.0 1.5 2 0 0 2 2 2 0 Bacterial TniB protein Glyco_hydro_18 PF00704.28 EKE37307.1 - 8.1e-08 32.3 0.6 9.3e-08 32.1 0.6 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 NS3_envE PF02723.14 EKE37307.1 - 0.61 10.2 3.8 0.19 11.8 0.5 1.9 2 0 0 2 2 2 0 Non-structural protein NS3/Small envelope protein E PI3_PI4_kinase PF00454.27 EKE37308.1 - 1.2e-11 44.9 0.3 7.8e-06 25.9 0.1 2.6 2 0 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase TRL PF13146.6 EKE37309.1 - 0.67 10.3 2.8 0.79 10.0 0.0 2.6 3 0 0 3 3 3 0 TRL-like protein family Chorein_N PF12624.7 EKE37310.1 - 3.5e-17 62.6 7.6 8.1e-17 61.4 1.6 3.0 2 0 0 2 2 2 2 N-terminal region of Chorein or VPS13 CENP-H PF05837.12 EKE37310.1 - 5.8 7.4 7.6 2.1 8.8 3.5 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Amidohydro_1 PF01979.20 EKE37311.1 - 1.7e-69 234.7 0.0 2e-69 234.6 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EKE37311.1 - 1.9e-06 27.6 0.0 0.0005 19.6 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family RHH_1 PF01402.21 EKE37311.1 - 0.53 10.3 2.1 10 6.3 0.0 3.2 4 0 0 4 4 4 0 Ribbon-helix-helix protein, copG family T4_baseplate PF12322.8 EKE37312.1 - 0.0074 15.8 0.4 0.015 14.8 0.4 1.5 1 0 0 1 1 1 1 T4 bacteriophage base plate protein Peptidase_S41 PF03572.18 EKE37312.1 - 0.0087 15.6 0.0 0.022 14.4 0.0 1.7 1 1 0 1 1 1 1 Peptidase family S41 EutQ PF06249.12 EKE37312.1 - 0.09 12.5 0.1 0.68 9.7 0.0 2.1 1 1 1 2 2 2 0 Ethanolamine utilisation protein EutQ EF-hand_1 PF00036.32 EKE37313.1 - 5.1e-26 88.2 21.1 1.2e-07 30.7 0.3 4.1 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EKE37313.1 - 1e-25 87.4 16.0 2.2e-07 30.3 0.1 4.1 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 EKE37313.1 - 1.7e-25 89.3 10.2 2.9e-14 53.3 1.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EKE37313.1 - 5.4e-21 73.1 9.4 4.1e-05 22.9 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EKE37313.1 - 6.7e-13 48.3 21.5 0.00032 20.5 1.7 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 EKE37313.1 - 4.3e-07 29.8 11.7 0.037 14.0 1.8 3.6 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EKE37313.1 - 1.2e-06 28.8 5.2 0.0024 18.2 0.3 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EKE37313.1 - 3.6e-05 23.5 7.8 0.0047 16.8 0.7 4.0 2 1 2 4 4 4 2 EF hand SAS-6_N PF16531.5 EKE37313.1 - 0.0025 18.4 1.4 0.039 14.5 0.1 2.5 1 1 2 3 3 3 1 Centriolar protein SAS N-terminal DUF2141 PF09912.9 EKE37313.1 - 0.0084 16.0 1.1 0.19 11.7 0.0 2.9 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2141) EF-hand_9 PF14658.6 EKE37313.1 - 0.018 15.3 4.8 0.89 9.9 0.7 2.9 2 2 0 2 2 2 0 EF-hand domain Caleosin PF05042.13 EKE37313.1 - 0.16 11.9 1.9 2.4 8.0 0.1 3.1 1 1 3 4 4 4 0 Caleosin related protein PMBR PF09373.10 EKE37313.1 - 0.18 12.0 0.1 10 6.5 0.0 3.0 3 0 0 3 3 3 0 Pseudomurein-binding repeat Dockerin_1 PF00404.18 EKE37313.1 - 0.35 11.1 5.2 2.2 8.6 1.7 3.0 1 1 2 3 3 3 0 Dockerin type I domain VCBS PF13517.6 EKE37313.1 - 3.2 8.4 8.9 24 5.6 0.0 3.7 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella zf-CCCH PF00642.24 EKE37314.1 - 1.5e-15 56.7 30.8 1.8e-05 24.5 2.6 4.4 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EKE37314.1 - 3.6e-12 47.0 24.1 4.2e-07 30.6 0.1 4.0 1 1 3 4 4 4 3 Torus domain zf_CCCH_4 PF18345.1 EKE37314.1 - 1.1e-11 44.4 42.9 1.2e-06 28.4 3.6 5.0 4 1 0 4 4 4 4 Zinc finger domain zf-CCCH_4 PF18044.1 EKE37314.1 - 5.2e-08 32.5 12.5 1.4e-05 24.8 1.4 4.4 5 0 0 5 5 5 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EKE37314.1 - 0.0001 22.5 16.4 0.0023 18.1 4.9 2.8 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.6 EKE37314.1 - 0.086 13.3 3.3 0.086 13.3 3.3 4.5 4 0 0 4 4 4 0 RNA-binding, Nab2-type zinc finger A_deamin PF02137.18 EKE37315.1 - 1.5e-50 172.5 0.1 2e-50 172.1 0.1 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain DUF1837 PF08878.11 EKE37317.1 - 0.02 14.7 7.3 0.073 12.8 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1837) Gti1_Pac2 PF09729.9 EKE37317.1 - 7.8 6.5 12.2 0.18 11.9 3.0 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family TolA_bind_tri PF16331.5 EKE37318.1 - 0.0026 17.8 1.1 0.0085 16.1 1.1 1.8 1 0 0 1 1 1 1 TolA binding protein trimerisation MtrB PF05440.12 EKE37318.1 - 0.13 12.7 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase subunit B Snapin_Pallidin PF14712.6 EKE37318.1 - 0.34 11.4 10.0 0.28 11.6 3.4 2.6 2 2 0 2 2 2 0 Snapin/Pallidin RasGAP_C PF03836.15 EKE37318.1 - 0.37 10.9 17.2 0.033 14.3 9.0 2.1 2 0 0 2 2 2 0 RasGAP C-terminus Dna2 PF08696.11 EKE37318.1 - 0.72 9.6 13.9 0.084 12.7 8.5 1.8 1 1 0 2 2 2 0 DNA replication factor Dna2 Ribosomal_S7e PF01251.18 EKE37319.1 - 9e-24 84.2 0.9 9.9e-24 84.1 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Adaptin_N PF01602.20 EKE37320.1 - 3e-78 263.7 12.9 5.4e-78 262.8 12.9 1.3 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EKE37320.1 - 6.8e-26 91.2 2.7 2.1e-25 89.6 2.7 1.9 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EKE37320.1 - 1.5e-24 86.3 0.0 3.5e-24 85.2 0.0 1.7 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform Cnd1 PF12717.7 EKE37320.1 - 2e-08 34.4 9.3 0.0015 18.6 0.2 3.9 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKE37320.1 - 2.9e-06 27.6 0.0 0.049 14.0 0.0 4.7 3 2 0 3 3 3 1 HEAT repeats HEAT PF02985.22 EKE37320.1 - 0.00013 21.9 0.0 11 6.5 0.0 5.4 5 0 0 5 5 5 1 HEAT repeat DUF1963 PF09234.10 EKE37324.1 - 4.1e-58 197.4 1.6 4.8e-58 197.1 1.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1963) WD40 PF00400.32 EKE37325.1 - 6.4e-15 55.3 12.7 0.0017 19.2 0.2 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE37325.1 - 1.5e-07 31.6 2.3 0.044 14.1 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Lactonase PF10282.9 EKE37325.1 - 0.021 14.1 0.0 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller BBS2_Mid PF14783.6 EKE37325.1 - 1.1 9.3 3.9 27 4.8 0.2 3.4 2 2 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region C2 PF00168.30 EKE37326.1 - 0.052 13.8 0.1 0.062 13.6 0.1 1.3 1 0 0 1 1 1 0 C2 domain CEP76-C2 PF15627.6 EKE37326.1 - 0.082 12.5 0.1 0.082 12.5 0.1 1.2 1 0 0 1 1 1 0 CEP76 C2 domain LIM PF00412.22 EKE37327.1 - 2.1e-53 178.4 62.6 4.9e-13 49.1 5.9 5.2 5 0 0 5 5 5 5 LIM domain BppL_N PF18338.1 EKE37327.1 - 0.05 13.4 0.1 0.092 12.5 0.1 1.4 1 0 0 1 1 1 0 Lower baseplate protein N-terminal domain DUF35_N PF12172.8 EKE37327.1 - 0.086 12.7 0.2 0.086 12.7 0.2 4.6 5 0 0 5 5 5 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DctP PF03480.13 EKE37327.1 - 1.9 7.8 7.2 2.6 7.3 7.2 1.1 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein, family 7 NARP1 PF12569.8 EKE37327.1 - 4.1 6.2 17.8 5.3 5.8 17.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Peptidase_M3 PF01432.20 EKE37328.1 - 2e-117 393.3 3.9 3.6e-117 392.4 3.9 1.5 1 0 0 1 1 1 1 Peptidase family M3 DUF3783 PF12646.7 EKE37328.1 - 0.052 13.5 0.0 0.25 11.3 0.0 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3783) DUF3420 PF11900.8 EKE37328.1 - 0.07 13.3 0.0 0.23 11.6 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3420) Myb_DNA-binding PF00249.31 EKE37329.1 - 8.4e-10 38.7 0.3 1.6e-09 37.8 0.3 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE37329.1 - 1.4e-05 25.2 1.2 3.3e-05 24.1 0.7 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain SLIDE PF09111.10 EKE37329.1 - 0.0009 19.2 1.9 0.002 18.2 0.7 2.1 1 1 1 2 2 2 1 SLIDE Myb_DNA-bind_5 PF13873.6 EKE37329.1 - 0.027 14.5 3.4 0.46 10.6 0.4 2.6 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain XPC-binding PF09280.11 EKE37329.1 - 0.57 10.0 3.6 1.7 8.4 0.5 3.1 3 0 0 3 3 3 0 XPC-binding domain Peptidase_C50 PF03568.17 EKE37329.1 - 0.7 9.0 4.4 1.3 8.0 1.7 2.2 2 1 0 3 3 3 0 Peptidase family C50 Myb_DNA-binding PF00249.31 EKE37331.1 - 7.4e-10 38.9 0.4 1.8e-09 37.6 0.3 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE37331.1 - 7.5e-06 26.1 0.9 1.7e-05 24.9 0.4 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 EKE37331.1 - 0.022 14.8 4.3 0.27 11.4 0.7 2.7 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain AAA_18 PF13238.6 EKE37332.1 - 6.9e-26 91.3 0.0 9.3e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EKE37332.1 - 2.8e-07 31.0 0.0 5.3e-07 30.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EKE37332.1 - 0.00026 21.4 0.1 0.00057 20.3 0.1 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 EKE37332.1 - 0.0013 18.5 0.0 0.0017 18.1 0.0 1.1 1 0 0 1 1 1 1 Cytidylate kinase DUF2075 PF09848.9 EKE37332.1 - 0.0017 17.7 0.0 0.0028 17.0 0.0 1.4 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EKE37332.1 - 0.0021 18.4 0.0 0.0026 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EKE37332.1 - 0.0022 18.3 0.0 0.0031 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKE37332.1 - 0.0031 17.8 0.2 0.0076 16.5 0.0 1.6 1 1 1 2 2 2 1 AAA domain ADK PF00406.22 EKE37332.1 - 0.0039 17.3 0.1 0.065 13.3 0.1 2.3 1 1 0 1 1 1 1 Adenylate kinase Zeta_toxin PF06414.12 EKE37332.1 - 0.018 14.3 0.0 0.042 13.1 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin NTPase_1 PF03266.15 EKE37332.1 - 0.023 14.6 0.0 0.045 13.7 0.0 1.6 2 0 0 2 2 2 0 NTPase AAA_33 PF13671.6 EKE37332.1 - 0.035 14.3 0.0 0.73 10.0 0.0 2.1 1 1 1 2 2 2 0 AAA domain Ras_bdg_2 PF14847.6 EKE37332.1 - 0.043 14.1 0.3 0.082 13.3 0.3 1.6 1 1 0 1 1 1 0 Ras-binding domain of Byr2 AAA_5 PF07728.14 EKE37332.1 - 0.051 13.6 0.1 0.27 11.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EKE37332.1 - 0.055 13.8 0.3 0.12 12.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EKE37332.1 - 0.08 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 KaiC Sigma54_activat PF00158.26 EKE37332.1 - 0.1 12.3 0.1 0.23 11.2 0.0 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Thymidylate_kin PF02223.17 EKE37332.1 - 0.15 11.7 0.1 8.2 6.1 0.1 2.2 2 0 0 2 2 2 0 Thymidylate kinase FtsK_SpoIIIE PF01580.18 EKE37332.1 - 0.19 11.1 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family MFS_1 PF07690.16 EKE37334.1 - 1.3e-11 44.1 38.5 2.4e-09 36.6 28.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Alpha_kinase PF02816.18 EKE37335.1 - 0.0024 18.0 10.1 0.016 15.4 10.1 2.3 1 1 0 1 1 1 1 Alpha-kinase family Apyrase PF06079.11 EKE37336.1 - 7.4e-69 232.2 8.2 9.1e-69 231.9 8.2 1.1 1 0 0 1 1 1 1 Apyrase NCBP3 PF10309.9 EKE37336.1 - 3.1 7.7 6.5 1.2e+02 2.6 6.5 2.9 1 1 0 1 1 1 0 Nuclear cap-binding protein subunit 3 NYN PF01936.18 EKE37337.1 - 0.023 15.2 0.0 0.081 13.4 0.0 1.8 2 0 0 2 2 2 0 NYN domain DUF5374 PF17344.2 EKE37339.1 - 0.043 13.7 0.5 0.07 13.1 0.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5374) EF-hand_7 PF13499.6 EKE37340.1 - 1e-16 61.1 3.4 1.4e-14 54.3 0.5 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EKE37340.1 - 2.1e-15 55.0 4.8 1.1e-06 27.7 0.1 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EKE37340.1 - 4.2e-11 41.8 4.8 1.9e-05 24.2 0.1 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 EKE37340.1 - 5.4e-11 41.5 2.8 6e-05 22.4 0.1 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EKE37340.1 - 4e-07 29.8 2.6 0.0017 18.2 0.2 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 EKE37340.1 - 7.7e-05 22.6 1.2 0.062 13.3 0.2 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EKE37340.1 - 0.0002 21.6 0.2 0.00038 20.8 0.2 1.7 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1967 PF09269.11 EKE37340.1 - 0.02 14.8 0.2 0.071 13.1 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) Csm2_III-A PF03750.13 EKE37340.1 - 0.12 13.2 1.2 0.16 12.8 0.4 1.6 2 0 0 2 2 2 0 Csm2 Type III-A DIMCO_N PF16844.5 EKE37340.1 - 0.12 12.7 0.1 2.1 8.8 0.0 2.7 1 1 1 3 3 3 0 Dinitrogenase iron-molybdenum cofactor, N-terminal tRNA_m1G_MT PF01746.21 EKE37341.1 - 7.2e-22 78.0 0.9 1.2e-21 77.3 0.9 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Apis_Csd PF11671.8 EKE37341.1 - 0.11 12.5 3.5 0.23 11.5 3.5 1.7 1 0 0 1 1 1 0 Complementary sex determiner protein Peptidase_M18 PF02127.15 EKE37342.1 - 1.8e-105 353.2 0.1 2.2e-105 353.0 0.1 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EKE37342.1 - 0.00029 20.0 0.7 0.078 12.0 0.2 2.1 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase GDPD PF03009.17 EKE37343.1 - 1.6e-50 172.3 0.0 2.9e-50 171.4 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family M16C_assoc PF08367.11 EKE37344.1 - 2.4e-40 138.3 1.1 4.7e-40 137.3 1.1 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EKE37344.1 - 2.7e-20 73.2 6.7 1.6e-17 64.1 0.7 3.1 3 1 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EKE37344.1 - 0.00071 19.6 0.4 0.0084 16.1 0.0 3.0 4 0 0 4 4 4 1 Insulinase (Peptidase family M16) MIT PF04212.18 EKE37346.1 - 1e-07 31.9 7.2 2.1e-07 30.9 0.9 3.3 2 1 1 3 3 3 1 MIT (microtubule interacting and transport) domain DAPDH_C PF16654.5 EKE37346.1 - 0.055 13.3 1.4 0.077 12.8 0.2 1.9 2 1 0 2 2 2 0 Diaminopimelic acid dehydrogenase C-terminal domain Aida_N PF08910.10 EKE37346.1 - 0.083 13.3 8.8 1.5 9.3 0.0 4.0 2 2 2 4 4 4 0 Aida N-terminus FliJ PF02050.16 EKE37346.1 - 1.3 9.3 27.3 0.13 12.4 15.6 3.0 2 1 0 2 2 2 0 Flagellar FliJ protein NifW PF03206.14 EKE37346.1 - 6.4 7.4 7.8 9.2 6.8 1.4 3.3 3 1 1 4 4 4 0 Nitrogen fixation protein NifW LMBR1 PF04791.16 EKE37346.1 - 9.3 5.0 9.8 10 4.9 9.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Thioredoxin PF00085.20 EKE37347.1 - 1.7e-21 76.1 0.1 2e-21 75.9 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EKE37347.1 - 0.001 19.3 0.2 0.0029 17.9 0.1 1.7 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EKE37347.1 - 0.0022 18.4 0.5 0.0043 17.5 0.5 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_4 PF13462.6 EKE37347.1 - 0.019 15.2 0.2 0.031 14.4 0.2 1.3 1 0 0 1 1 1 0 Thioredoxin ERp29_N PF07912.13 EKE37347.1 - 0.032 14.4 0.1 0.047 13.8 0.1 1.3 1 1 0 1 1 1 0 ERp29, N-terminal domain Thioredoxin_7 PF13899.6 EKE37347.1 - 0.058 13.6 0.1 0.11 12.7 0.1 1.7 1 1 0 1 1 1 0 Thioredoxin-like DHR-2 PF06920.13 EKE37348.1 - 8.9e-43 146.7 0.7 8.9e-43 146.7 0.7 3.3 3 1 0 3 3 3 1 Dock homology region 2 Rx_N PF18052.1 EKE37348.1 - 0.028 14.7 0.3 0.028 14.7 0.3 3.7 4 0 0 4 4 4 0 Rx N-terminal domain Methyltransf_31 PF13847.6 EKE37348.1 - 0.13 12.1 1.6 1.1 9.0 0.3 2.7 2 0 0 2 2 2 0 Methyltransferase domain SesA PF17107.5 EKE37348.1 - 1.3 9.3 8.4 0.22 11.7 0.2 3.8 4 0 0 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Orthopox_F14 PF06076.12 EKE37348.1 - 2.4 8.5 5.0 2.8 8.3 0.2 2.9 2 0 0 2 2 2 0 Orthopoxvirus F14 protein DUF747 PF05346.11 EKE37350.1 - 5.8e-71 239.6 25.3 7.7e-71 239.2 25.3 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family Ribo_biogen_C PF04034.13 EKE37351.1 - 2.2e-45 153.5 0.0 2.8e-45 153.1 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EKE37351.1 - 3.3e-11 42.8 1.3 7.4e-11 41.7 1.3 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI MIR PF02815.19 EKE37353.1 - 0.0059 16.5 0.1 0.031 14.1 0.1 1.9 1 1 1 2 2 2 1 MIR domain DUF2175 PF09943.9 EKE37354.1 - 1 9.7 5.9 3.8 7.9 5.9 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) DUF2935 PF11155.8 EKE37355.1 - 0.041 14.2 0.7 0.041 14.2 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) Med26 PF08711.11 EKE37355.1 - 0.16 12.0 2.5 1.4 9.0 0.4 2.5 2 0 0 2 2 2 0 TFIIS helical bundle-like domain U62_UL91 PF17442.2 EKE37356.1 - 0.068 13.2 0.2 0.2 11.6 0.2 1.8 1 0 0 1 1 1 0 Functional domain of U62 and UL91 proteins DENN PF02141.21 EKE37357.1 - 5e-28 98.3 1.0 5e-28 98.3 1.0 1.9 2 0 0 2 2 2 1 DENN (AEX-3) domain dDENN PF03455.19 EKE37357.1 - 1.5e-07 31.3 0.7 3.6e-07 30.1 0.7 1.7 1 0 0 1 1 1 1 dDENN domain LIM PF00412.22 EKE37357.1 - 0.2 11.9 9.5 0.45 10.8 9.5 1.6 1 0 0 1 1 1 0 LIM domain Orn_Arg_deC_N PF02784.16 EKE37358.1 - 2.5e-59 200.6 0.0 3.5e-59 200.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EKE37358.1 - 5.7e-07 29.7 0.0 8.3e-07 29.2 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ala_racemase_N PF01168.20 EKE37358.1 - 9e-07 28.8 0.0 1.4e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain AP_endonuc_2 PF01261.24 EKE37358.1 - 0.0029 17.1 0.0 0.026 14.0 0.0 2.3 2 1 1 3 3 3 2 Xylose isomerase-like TIM barrel DSPc PF00782.20 EKE37359.1 - 9.2e-33 112.9 0.1 1.2e-32 112.5 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EKE37359.1 - 0.00063 19.4 0.0 0.00093 18.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EKE37359.1 - 0.0047 17.2 0.0 0.0097 16.2 0.0 1.5 1 1 0 1 1 1 1 Rit1 DUSP-like domain HBS1_N PF08938.10 EKE37359.1 - 0.16 12.3 0.0 0.37 11.1 0.0 1.6 1 0 0 1 1 1 0 HBS1 N-terminus NAPRTase PF04095.16 EKE37361.1 - 2.4e-53 181.2 0.0 3.8e-53 180.6 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 EKE37361.1 - 4.8e-28 98.0 0.5 1.2e-27 96.8 0.2 1.7 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain RasGEF PF00617.19 EKE37362.1 - 3.1e-41 141.5 0.1 8.6e-41 140.1 0.1 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE37362.1 - 8.5e-13 48.5 0.7 4.4e-12 46.2 0.1 2.6 2 0 0 2 2 2 1 RasGEF N-terminal motif FliJ PF02050.16 EKE37362.1 - 2.8 8.2 13.0 3 8.1 9.3 2.5 1 1 1 2 2 2 0 Flagellar FliJ protein Flp_N PF03930.14 EKE37362.1 - 3.4 7.7 7.1 7.5 6.6 0.1 3.9 3 0 0 3 3 3 0 Recombinase Flp protein N-terminus HTH_44 PF14641.6 EKE37363.1 - 0.045 14.2 0.6 0.11 12.9 0.2 1.8 2 0 0 2 2 2 0 Helix-turn-helix DNA-binding domain of SPT6 TPR_1 PF00515.28 EKE37365.1 - 6.2e-54 177.7 42.7 2.8e-09 36.4 0.9 9.3 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 EKE37365.1 - 3.6e-47 154.7 35.4 1.3e-06 28.0 0.4 9.3 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 EKE37365.1 - 4.1e-35 119.2 26.5 6.9e-10 38.4 0.2 8.3 6 2 3 9 9 9 5 TPR repeat STI1 PF17830.1 EKE37365.1 - 4.1e-32 109.9 3.6 1.8e-15 56.6 0.0 3.0 3 0 0 3 3 2 2 STI1 domain TPR_8 PF13181.6 EKE37365.1 - 2.6e-26 89.6 38.2 0.0002 21.3 0.5 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_16 PF13432.6 EKE37365.1 - 6.7e-21 74.7 0.0 0.00011 22.7 0.0 6.1 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 EKE37365.1 - 1.1e-20 73.9 5.6 0.0027 18.2 0.0 6.5 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 EKE37365.1 - 3.6e-19 68.8 12.8 3.3e-05 24.1 0.1 6.9 5 2 1 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EKE37365.1 - 6.3e-19 67.1 0.5 0.039 14.8 0.0 8.2 5 3 4 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 EKE37365.1 - 2.9e-18 64.9 17.4 7.5e-05 22.8 0.4 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 EKE37365.1 - 2.1e-14 52.4 10.6 0.042 13.9 0.0 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EKE37365.1 - 3e-12 46.4 17.8 0.0013 18.8 0.1 7.4 7 1 1 8 8 8 3 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 EKE37365.1 - 2e-10 40.6 0.0 0.0012 18.9 0.0 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE37365.1 - 2.3e-08 34.2 22.6 0.0034 17.6 0.3 5.0 3 3 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EKE37365.1 - 7.4e-08 32.0 12.0 0.54 10.2 0.0 7.5 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 EKE37365.1 - 1.6e-06 28.3 15.1 1.9 9.3 0.1 8.0 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_3 PF07720.12 EKE37365.1 - 1.7e-05 24.7 14.1 0.13 12.3 0.1 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_20 PF14561.6 EKE37365.1 - 5.5e-05 23.4 0.2 3.3 8.1 0.0 4.9 4 2 1 5 5 5 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EKE37365.1 - 0.00014 21.2 7.5 0.95 9.0 0.1 7.0 9 0 0 9 9 9 1 SHNi-TPR MIT PF04212.18 EKE37365.1 - 0.0014 18.7 29.8 1.4 9.1 0.0 7.7 8 0 0 8 8 7 3 MIT (microtubule interacting and transport) domain Alkyl_sulf_dimr PF14863.6 EKE37365.1 - 0.0021 18.5 11.8 0.23 11.9 0.0 4.6 4 1 1 5 5 5 1 Alkyl sulfatase dimerisation Rapsyn_N PF10579.9 EKE37365.1 - 0.12 12.5 1.7 0.37 10.9 0.5 2.6 2 0 0 2 2 2 0 Rapsyn N-terminal myristoylation and linker region Roughex PF06020.11 EKE37365.1 - 0.33 10.0 0.0 0.33 10.0 0.0 2.5 3 0 0 3 3 2 0 Drosophila roughex protein DUF3856 PF12968.7 EKE37365.1 - 0.45 10.6 11.2 3.8 7.6 1.7 5.1 4 2 1 5 5 5 0 Domain of Unknown Function (DUF3856) Clr2 PF10383.9 EKE37365.1 - 0.85 10.4 3.4 3 8.6 1.4 2.5 2 0 0 2 2 2 0 Transcription-silencing protein Clr2 SPOB_a PF14689.6 EKE37365.1 - 1.1 9.0 4.7 15 5.4 0.2 3.2 3 0 0 3 3 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain PPR PF01535.20 EKE37365.1 - 2.1 8.8 11.8 37 4.9 0.0 6.2 6 0 0 6 6 6 0 PPR repeat NRBF2_MIT PF17169.4 EKE37365.1 - 4.9 7.4 12.5 0.42 10.9 0.1 4.6 4 1 1 5 5 5 0 MIT domain of nuclear receptor-binding factor 2 IBR PF01485.21 EKE37366.1 - 2.5e-07 30.8 52.4 9.1e-06 25.8 8.9 4.0 4 0 0 4 4 4 3 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 EKE37366.1 - 1.2e-05 25.3 2.4 1.2e-05 25.3 2.4 3.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EKE37366.1 - 1.8e-05 24.5 3.0 1.8e-05 24.5 3.0 4.6 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) THP2 PF09432.10 EKE37366.1 - 0.41 10.7 4.8 0.63 10.1 1.4 2.5 2 1 0 2 2 2 0 Tho complex subunit THP2 Med27 PF11571.8 EKE37367.1 - 0.044 14.1 1.5 1.3 9.4 0.5 2.9 2 0 0 2 2 2 0 Mediator complex subunit 27 DUF948 PF06103.11 EKE37367.1 - 0.063 13.5 1.8 10 6.5 1.1 3.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 EKE37367.1 - 0.45 11.0 8.5 4.4 7.8 0.9 3.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein CTD_bind PF04818.13 EKE37367.1 - 3.2 8.7 6.7 18 6.3 2.2 4.0 2 1 0 2 2 2 0 RNA polymerase II-binding domain. DUF3450 PF11932.8 EKE37367.1 - 7.9 5.7 13.4 5 6.3 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) HATPase_c PF02518.26 EKE37368.1 - 0.0018 18.7 0.5 0.0062 17.0 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ANAPC4_WD40 PF12894.7 EKE37370.1 - 0.0064 16.8 2.3 2.5 8.4 0.3 3.8 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Rav1p_C PF12234.8 EKE37370.1 - 0.026 13.0 0.6 0.036 12.5 0.6 1.1 1 0 0 1 1 1 0 RAVE protein 1 C terminal Alpha-amylase PF00128.24 EKE37371.1 - 1.5e-09 37.9 4.8 1.6e-08 34.6 1.7 3.0 2 1 0 2 2 2 1 Alpha amylase, catalytic domain Gryzun-like PF12742.7 EKE37373.1 - 2.2e-05 24.4 0.2 0.00025 21.0 0.1 2.5 2 0 0 2 2 2 1 Gryzun, putative Golgi trafficking TPR_8 PF13181.6 EKE37373.1 - 0.0047 17.0 1.2 0.092 13.0 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EKE37373.1 - 0.0074 16.3 0.0 0.095 12.9 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EKE37373.1 - 0.019 15.0 0.0 1.8 8.8 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Orthoreo_P17 PF07272.11 EKE37373.1 - 0.025 14.6 0.7 0.43 10.6 0.1 2.6 2 0 0 2 2 2 0 Orthoreovirus P17 protein TRAPPC10 PF12584.8 EKE37373.1 - 0.1 12.3 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 TPR_1 PF00515.28 EKE37373.1 - 0.21 11.5 2.5 0.47 10.4 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DENN PF02141.21 EKE37374.1 - 1.4e-16 61.0 6.2 2.5e-15 56.9 6.1 2.4 2 0 0 2 2 2 1 DENN (AEX-3) domain Mycoplasma_p37 PF06646.11 EKE37374.1 - 0.0024 17.2 0.1 0.0045 16.3 0.1 1.4 1 0 0 1 1 1 1 High affinity transport system protein p37 uDENN PF03456.18 EKE37374.1 - 0.0027 18.4 0.2 0.01 16.6 0.2 2.1 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EKE37374.1 - 0.0064 16.5 1.0 0.023 14.7 0.1 2.4 3 0 0 3 3 3 1 dDENN domain Orthopox_A5L PF06193.11 EKE37374.1 - 0.03 13.8 0.5 0.059 12.8 0.5 1.4 1 0 0 1 1 1 0 Orthopoxvirus A5L protein-like REV PF00424.18 EKE37375.1 - 0.037 14.0 0.2 0.037 14.0 0.2 2.3 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Nsp1_C PF05064.13 EKE37375.1 - 0.039 13.8 8.2 0.14 12.0 4.8 2.4 2 0 0 2 2 2 0 Nsp1-like C-terminal region YqzE PF14038.6 EKE37375.1 - 0.67 10.0 0.0 0.67 10.0 0.0 4.5 5 1 0 5 5 5 0 YqzE-like protein Suppressor_APC PF11414.8 EKE37375.1 - 9.4 6.4 11.7 0.97 9.5 2.4 3.1 3 0 0 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein Cation_efflux PF01545.21 EKE37376.1 - 8.1e-25 87.7 13.9 9.6e-25 87.5 13.9 1.1 1 0 0 1 1 1 1 Cation efflux family DUF697 PF05128.12 EKE37376.1 - 0.16 11.7 0.9 0.26 11.0 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF697) DUF1129 PF06570.11 EKE37376.1 - 2.9 7.3 9.7 0.13 11.7 1.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) UL41A PF17591.2 EKE37376.1 - 3.5 7.8 12.2 0.5 10.5 3.8 3.0 2 1 1 3 3 3 0 Herpesvirus UL41A Proteasome PF00227.26 EKE37377.1 - 5.5e-35 120.6 0.0 6.9e-35 120.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF2121 PF09894.9 EKE37377.1 - 0.1 12.1 0.1 0.23 11.0 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2121) Peptidase_C25 PF01364.18 EKE37377.1 - 0.11 11.6 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Peptidase family C25 Read-through PF16814.5 EKE37378.1 - 0.2 11.5 0.0 0.36 10.6 0.0 1.3 1 0 0 1 1 1 0 Read-through domain RhoGEF PF00621.20 EKE37380.1 - 4.3e-39 134.6 0.4 4.3e-39 134.6 0.4 2.2 2 1 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 EKE37380.1 - 1.2e-12 47.7 15.5 3.1e-12 46.5 15.5 1.7 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EKE37380.1 - 3.6e-06 27.4 3.2 5.3e-06 26.9 0.2 2.5 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 EKE37380.1 - 0.016 15.0 3.1 4 7.2 0.1 3.0 1 1 1 2 2 2 0 Pleckstrin homology domain C1_2 PF03107.16 EKE37380.1 - 2 8.8 12.9 0.33 11.3 7.7 2.2 2 0 0 2 2 2 0 C1 domain DUF547 PF04784.14 EKE37381.1 - 9.4e-19 67.7 0.0 3.4e-18 65.8 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF547 PTEN_C2 PF10409.9 EKE37381.1 - 7.7e-15 54.8 0.4 1e-13 51.2 0.4 2.8 1 1 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein PTPlike_phytase PF14566.6 EKE37381.1 - 0.0034 17.5 0.1 0.013 15.6 0.0 2.0 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EKE37381.1 - 0.031 14.2 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Tyrosine phosphatase family DSPc PF00782.20 EKE37381.1 - 0.034 14.0 0.6 1.6 8.5 0.0 3.2 2 1 1 3 3 3 0 Dual specificity phosphatase, catalytic domain Peptidase_M16 PF00675.20 EKE37382.1 - 6.1e-14 52.2 0.0 9.9e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EKE37382.1 - 0.085 12.9 2.5 0.12 12.4 1.4 1.8 2 0 0 2 2 2 0 Peptidase M16 inactive domain TM1586_NiRdase PF14512.6 EKE37383.1 - 2.1e-26 92.9 0.0 3.3e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Putative TM nitroreductase Nitroreductase PF00881.24 EKE37383.1 - 1.5e-11 44.6 0.1 0.0014 18.7 0.0 3.3 3 0 0 3 3 3 3 Nitroreductase family RNA_helicase PF00910.22 EKE37386.1 - 0.0016 18.8 0.3 0.0047 17.3 0.2 1.9 1 1 1 2 2 2 1 RNA helicase Ploopntkinase1 PF18748.1 EKE37386.1 - 0.0028 17.2 0.1 0.0041 16.7 0.1 1.2 1 0 0 1 1 1 1 P-loop Nucleotide Kinase1 ATPase_2 PF01637.18 EKE37386.1 - 0.022 14.7 0.9 0.028 14.3 0.2 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea PSRP-3_Ycf65 PF04839.13 EKE37386.1 - 0.05 13.8 0.1 0.16 12.2 0.0 2.0 2 0 0 2 2 2 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) Hpr_kinase_C PF07475.12 EKE37386.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain TPR_2 PF07719.17 EKE37387.1 - 2.2e-26 89.8 0.7 0.0043 17.1 0.0 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 EKE37387.1 - 3.5e-23 80.4 3.0 0.00033 20.3 0.0 8.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 EKE37387.1 - 1.1e-14 53.6 0.1 0.076 13.4 0.0 7.6 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 EKE37387.1 - 2.6e-13 49.4 0.7 0.00019 21.0 0.0 5.6 4 1 2 6 6 6 3 TPR repeat TPR_19 PF14559.6 EKE37387.1 - 3.3e-13 50.0 0.1 0.0018 18.7 0.0 4.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKE37387.1 - 7e-13 47.7 1.2 2.3 8.7 0.1 7.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 EKE37387.1 - 3e-12 46.5 0.0 8.4e-05 22.6 0.0 5.4 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EKE37387.1 - 3.1e-12 46.9 0.0 0.2 12.3 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EKE37387.1 - 1.8e-10 40.7 0.0 2.7 9.0 0.0 6.5 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 EKE37387.1 - 1.8e-08 34.5 0.5 1.2 9.5 0.0 6.2 3 2 4 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EKE37387.1 - 0.00026 21.4 1.1 0.47 11.2 0.0 5.5 7 0 0 7 7 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE37387.1 - 0.00061 20.0 0.8 0.36 11.1 0.0 4.2 4 1 1 5 5 4 1 Anaphase-promoting complex, cyclosome, subunit 3 UBA_4 PF14555.6 EKE37387.1 - 0.0019 18.0 0.2 0.11 12.3 0.1 2.4 2 0 0 2 2 2 1 UBA-like domain TPR_7 PF13176.6 EKE37387.1 - 0.011 15.7 0.0 58 4.0 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EKE37387.1 - 0.022 14.6 0.1 83 3.2 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 EKE37387.1 - 0.027 14.8 0.1 2.4 8.5 0.0 2.7 1 1 0 2 2 2 0 Tetratricopeptide repeat SinI PF08671.10 EKE37387.1 - 0.052 13.3 0.1 0.22 11.4 0.0 2.2 2 0 0 2 2 2 0 Anti-repressor SinI LAGLIDADG_WhiA PF14527.6 EKE37387.1 - 0.088 12.9 0.1 4.5 7.4 0.0 2.7 2 0 0 2 2 2 0 WhiA LAGLIDADG-like domain HrpB1_HrpK PF09613.10 EKE37387.1 - 0.17 11.6 0.0 19 4.9 0.0 2.8 3 0 0 3 3 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Ras PF00071.22 EKE37388.1 - 1.4e-06 28.0 0.7 1.7e-06 27.7 0.7 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EKE37388.1 - 0.014 15.5 0.0 0.021 14.9 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Roc PF08477.13 EKE37388.1 - 0.044 14.0 0.0 0.071 13.3 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RabGAP-TBC PF00566.18 EKE37389.1 - 1.7e-33 116.1 9.9 2.4e-33 115.6 9.9 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain TIP49 PF06068.13 EKE37390.1 - 3.5e-141 470.5 4.6 4.9e-141 470.0 4.6 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EKE37390.1 - 6.7e-23 80.6 1.0 3.9e-22 78.1 1.0 2.3 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EKE37390.1 - 1e-09 38.9 0.8 3e-06 27.7 0.1 2.9 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EKE37390.1 - 8.5e-09 35.3 0.4 1.1e-05 25.2 0.1 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EKE37390.1 - 3.6e-08 34.0 0.6 1.2e-07 32.3 0.6 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EKE37390.1 - 6.7e-07 29.4 1.2 0.00074 19.5 0.0 2.9 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) DnaB_C PF03796.15 EKE37390.1 - 2e-05 24.1 0.2 5e-05 22.8 0.2 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 EKE37390.1 - 2.2e-05 24.7 0.1 0.17 12.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EKE37390.1 - 4.2e-05 23.0 0.5 0.0016 17.9 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EKE37390.1 - 0.00038 20.1 0.1 0.001 18.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EKE37390.1 - 0.00046 20.1 0.0 0.00079 19.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 EKE37390.1 - 0.0006 20.2 1.0 0.0006 20.2 1.0 2.5 3 1 0 3 3 1 1 AAA domain Sigma54_activat PF00158.26 EKE37390.1 - 0.0015 18.3 0.1 0.65 9.7 0.1 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.6 EKE37390.1 - 0.0015 18.7 0.0 0.0053 16.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 EKE37390.1 - 0.0044 16.3 0.1 0.009 15.3 0.0 1.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) TsaE PF02367.17 EKE37390.1 - 0.0049 16.9 0.1 0.0097 15.9 0.1 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EKE37390.1 - 0.0053 16.5 1.3 0.038 13.7 0.3 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EKE37390.1 - 0.0077 15.5 0.5 0.023 14.0 0.3 1.8 1 1 0 1 1 1 1 Zeta toxin AAA_18 PF13238.6 EKE37390.1 - 0.014 15.9 0.2 0.047 14.2 0.0 2.0 3 0 0 3 3 1 0 AAA domain AAA_7 PF12775.7 EKE37390.1 - 0.019 14.5 0.1 0.1 12.1 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EKE37390.1 - 0.029 14.7 0.0 0.064 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 EKE37390.1 - 0.046 13.4 0.1 0.098 12.4 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EKE37390.1 - 0.066 12.9 0.4 1 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EKE37390.1 - 0.067 13.4 0.3 0.17 12.1 0.3 1.7 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EKE37390.1 - 0.085 12.9 0.1 2 8.4 0.1 2.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit CbiA PF01656.23 EKE37390.1 - 0.091 12.8 0.2 0.3 11.1 0.2 1.9 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 EKE37391.1 - 2.7e-93 309.4 0.0 2.6e-45 154.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKE37391.1 - 1.3e-23 82.5 5.4 3.3e-11 42.8 0.3 3.2 2 1 1 3 3 3 2 AAA+ lid domain AAA_16 PF13191.6 EKE37391.1 - 3e-14 53.8 3.9 8.8e-06 26.2 1.1 4.3 2 2 2 4 4 4 2 AAA ATPase domain RuvB_N PF05496.12 EKE37391.1 - 5.5e-14 52.2 0.0 3.9e-06 26.7 0.0 3.0 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EKE37391.1 - 3e-12 46.7 0.1 1.8e-05 24.8 0.0 3.6 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EKE37391.1 - 5.9e-12 46.0 0.0 0.00013 22.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EKE37391.1 - 6.2e-12 46.0 5.0 0.0041 17.4 0.9 5.1 2 2 1 3 3 3 2 AAA domain AAA_33 PF13671.6 EKE37391.1 - 6.7e-10 39.3 0.0 0.00044 20.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EKE37391.1 - 6.4e-09 35.9 2.1 0.092 12.7 0.1 4.0 2 2 1 3 3 3 3 NACHT domain IstB_IS21 PF01695.17 EKE37391.1 - 8e-09 35.5 0.0 0.0051 16.6 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 EKE37391.1 - 1e-08 35.5 0.0 0.0016 18.8 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EKE37391.1 - 1.1e-08 35.2 0.0 0.0049 16.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EKE37391.1 - 4.7e-08 33.6 0.0 0.0075 16.8 0.0 2.7 2 1 0 2 2 2 2 AAA domain Rad17 PF03215.15 EKE37391.1 - 6.2e-07 29.5 0.0 0.042 13.8 0.0 2.7 2 0 0 2 2 2 2 Rad17 P-loop domain TIP49 PF06068.13 EKE37391.1 - 7.2e-07 28.7 0.0 0.0021 17.3 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_28 PF13521.6 EKE37391.1 - 1e-06 29.1 0.0 0.053 13.8 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EKE37391.1 - 1.3e-06 28.1 4.5 2.8 7.5 0.0 4.4 3 1 0 4 4 4 2 AAA domain Mg_chelatase PF01078.21 EKE37391.1 - 1.4e-06 27.8 1.2 0.024 14.0 0.2 3.1 3 1 1 4 4 2 2 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EKE37391.1 - 1.5e-06 28.2 0.0 0.087 12.8 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EKE37391.1 - 2.4e-06 27.0 0.3 0.024 13.9 0.0 2.9 3 0 0 3 3 3 2 Zeta toxin AAA_3 PF07726.11 EKE37391.1 - 2.7e-06 27.3 0.0 0.019 14.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EKE37391.1 - 5e-06 26.4 0.0 0.12 12.1 0.0 2.6 3 0 0 3 3 2 2 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 EKE37391.1 - 5.9e-06 26.8 0.0 0.017 15.7 0.0 3.0 2 0 0 2 2 2 1 ABC transporter AAA_24 PF13479.6 EKE37391.1 - 1.5e-05 24.9 0.1 0.039 13.7 0.0 2.6 2 1 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 EKE37391.1 - 2e-05 24.4 0.1 0.48 10.1 0.0 3.6 3 1 0 3 3 2 2 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EKE37391.1 - 3.8e-05 23.8 0.1 0.073 13.2 0.0 3.2 2 1 1 3 3 3 1 Sigma-54 interaction domain ATPase_2 PF01637.18 EKE37391.1 - 6e-05 23.1 1.5 1.6 8.6 0.0 4.4 3 2 1 4 4 3 2 ATPase domain predominantly from Archaea AAA_17 PF13207.6 EKE37391.1 - 7.5e-05 23.2 0.1 0.51 10.8 0.0 3.0 3 0 0 3 3 2 2 AAA domain ATPase PF06745.13 EKE37391.1 - 0.00018 20.9 2.0 0.27 10.5 0.0 3.9 4 1 1 5 5 4 1 KaiC Bac_DnaA PF00308.18 EKE37391.1 - 0.00024 21.0 0.0 1.2 8.9 0.0 3.2 2 2 0 2 2 2 2 Bacterial dnaA protein DUF815 PF05673.13 EKE37391.1 - 0.00031 20.0 0.0 0.23 10.6 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 EKE37391.1 - 0.00038 19.7 0.0 0.78 8.8 0.0 2.4 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Vps4_C PF09336.10 EKE37391.1 - 0.00044 20.2 0.1 0.37 10.8 0.0 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Cytidylate_kin2 PF13189.6 EKE37391.1 - 0.0005 20.3 0.2 0.095 12.8 0.0 2.9 3 0 0 3 3 3 1 Cytidylate kinase-like family AAA_7 PF12775.7 EKE37391.1 - 0.00061 19.4 0.0 0.55 9.7 0.0 2.9 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_11 PF13086.6 EKE37391.1 - 0.0019 18.0 0.3 2.5 7.8 0.0 2.8 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 EKE37391.1 - 0.0021 17.3 0.0 0.42 9.8 0.0 2.7 3 0 0 3 3 2 1 NB-ARC domain NTPase_1 PF03266.15 EKE37391.1 - 0.0025 17.8 0.1 3.6 7.5 0.0 3.6 3 1 0 3 3 3 0 NTPase SKI PF01202.22 EKE37391.1 - 0.0028 17.8 0.1 2.6 8.1 0.0 2.8 2 0 0 2 2 2 1 Shikimate kinase PhoH PF02562.16 EKE37391.1 - 0.006 16.1 0.5 4.6 6.6 0.0 2.7 3 0 0 3 3 2 0 PhoH-like protein AAA_19 PF13245.6 EKE37391.1 - 0.008 16.5 0.6 4.7 7.5 0.0 3.0 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 EKE37391.1 - 0.0083 15.5 0.0 32 3.8 0.0 3.7 3 1 0 3 3 3 0 Bacterial TniB protein DUF2075 PF09848.9 EKE37391.1 - 0.022 14.0 0.0 5.2 6.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Cytidylate_kin PF02224.18 EKE37391.1 - 0.023 14.5 0.5 4 7.1 0.0 3.0 3 0 0 3 3 3 0 Cytidylate kinase Zot PF05707.12 EKE37391.1 - 0.024 14.3 0.0 5.1 6.7 0.0 3.6 3 1 0 3 3 3 0 Zonular occludens toxin (Zot) CPT PF07931.12 EKE37391.1 - 0.033 14.0 0.0 3.7 7.3 0.0 2.7 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein PduV-EutP PF10662.9 EKE37391.1 - 0.034 13.9 0.0 4.9 6.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 EKE37391.1 - 0.035 13.8 0.0 11 5.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain Hydin_ADK PF17213.3 EKE37391.1 - 0.037 14.3 1.4 5 7.4 0.0 2.9 3 0 0 3 3 2 0 Hydin Adenylate kinase-like domain HD_assoc PF13286.6 EKE37391.1 - 0.098 13.2 0.1 5 7.7 0.0 2.8 2 0 0 2 2 2 0 Phosphohydrolase-associated domain ResIII PF04851.15 EKE37391.1 - 0.11 12.4 0.0 12 5.8 0.0 2.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Torsin PF06309.11 EKE37391.1 - 0.13 12.3 0.0 22 5.2 0.0 2.5 2 0 0 2 2 2 0 Torsin ADK PF00406.22 EKE37391.1 - 0.2 11.7 1.1 31 4.6 0.0 3.0 3 0 0 3 3 3 0 Adenylate kinase IBR PF01485.21 EKE37392.1 - 2.9e-10 40.2 11.6 2.9e-10 40.2 11.6 2.9 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain PARP PF00644.20 EKE37392.1 - 6.3e-08 32.4 0.3 1.2e-07 31.6 0.3 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Transpos_assoc PF13963.6 EKE37392.1 - 0.0013 19.0 1.9 0.0013 19.0 1.9 2.3 2 0 0 2 2 2 1 Transposase-associated domain NAD_synthase PF02540.17 EKE37393.1 - 5.6e-37 127.1 0.0 6.6e-37 126.9 0.0 1.0 1 0 0 1 1 1 1 NAD synthase tRNA_Me_trans PF03054.16 EKE37393.1 - 0.016 14.0 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase Init_tRNA_PT PF04179.12 EKE37393.1 - 0.12 12.6 0.1 0.27 11.6 0.1 1.6 1 0 0 1 1 1 0 Rit1 DUSP-like domain Arf PF00025.21 EKE37394.1 - 4.1e-32 111.0 0.0 1.8e-30 105.7 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EKE37394.1 - 1.5e-07 30.9 0.6 3.7e-05 23.0 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EKE37394.1 - 2.9e-07 30.7 0.1 6.3e-07 29.6 0.1 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EKE37394.1 - 4.8e-05 23.0 0.0 7.9e-05 22.3 0.0 1.4 1 1 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EKE37394.1 - 0.003 16.9 0.0 0.011 15.2 0.0 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_18 PF13238.6 EKE37394.1 - 0.067 13.7 0.4 0.34 11.5 0.4 2.2 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 EKE37394.1 - 0.19 11.2 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EKE37394.1 - 0.21 11.1 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Fe_hyd_lg_C PF02906.14 EKE37395.1 - 2.2e-67 227.3 3.9 3e-67 226.8 3.9 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fer4_15 PF13459.6 EKE37395.1 - 9.8e-10 39.0 0.4 0.0031 18.2 0.0 2.9 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4 PF00037.27 EKE37395.1 - 3.7e-09 36.0 11.0 3.4e-06 26.6 2.1 3.3 3 0 0 3 3 2 2 4Fe-4S binding domain Fe_hyd_SSU PF02256.17 EKE37395.1 - 1.6e-07 31.3 0.5 2.8e-07 30.5 0.5 1.3 1 0 0 1 1 1 1 Iron hydrogenase small subunit Fer4_7 PF12838.7 EKE37395.1 - 4.3e-07 30.4 20.3 1.7e-06 28.5 10.5 3.6 3 1 1 4 4 4 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EKE37395.1 - 8.2e-07 29.1 6.2 8.2e-07 29.1 6.2 3.4 3 1 0 3 3 3 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 EKE37395.1 - 3.8e-05 23.7 3.5 0.0012 18.9 0.3 3.1 3 0 0 3 3 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EKE37395.1 - 0.00013 22.0 2.8 0.0052 16.9 0.2 3.4 3 0 0 3 3 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EKE37395.1 - 0.00025 21.0 1.7 0.00025 21.0 1.7 3.4 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EKE37395.1 - 0.00025 21.5 21.7 0.00058 20.4 11.3 2.9 2 1 1 3 3 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 EKE37395.1 - 0.0035 18.3 17.1 0.024 15.5 9.7 3.5 3 2 2 5 5 3 3 4Fe-4S double cluster binding domain DUF4850 PF16142.5 EKE37395.1 - 0.0048 16.4 0.6 0.042 13.3 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4850) Fer4_2 PF12797.7 EKE37395.1 - 0.0051 16.8 2.1 0.0051 16.8 2.1 3.5 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_22 PF17179.4 EKE37395.1 - 0.019 15.8 13.4 0.065 14.1 0.5 2.9 3 0 0 3 3 2 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 EKE37395.1 - 0.062 13.8 0.5 0.062 13.8 0.5 3.7 3 1 1 4 4 4 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 EKE37395.1 - 8.3 7.0 13.6 8.7 7.0 3.2 3.0 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I CNOT1_TTP_bind PF16417.5 EKE37396.1 - 0.0029 16.8 4.3 0.0058 15.8 4.3 1.6 1 1 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain WTX PF09422.10 EKE37396.1 - 0.024 13.8 0.2 0.024 13.8 0.2 1.1 1 0 0 1 1 1 0 WTX protein TBCC_N PF16752.5 EKE37396.1 - 0.13 12.7 9.6 0.12 12.8 7.4 1.9 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain YccV-like PF08755.11 EKE37396.1 - 0.2 12.1 2.4 5.1 7.7 0.3 2.4 1 1 1 2 2 2 0 Hemimethylated DNA-binding protein YccV like Med26_C PF15693.5 EKE37396.1 - 0.86 9.7 7.3 1.2 9.3 6.8 1.5 1 1 0 1 1 1 0 Mediator complex subunit 26 C-terminal Snf7 PF03357.21 EKE37396.1 - 3.8 7.1 12.0 1 8.9 8.7 1.6 2 0 0 2 2 2 0 Snf7 DENN PF02141.21 EKE37397.1 - 1.5e-12 47.8 1.6 1.1e-11 45.0 1.0 2.3 2 0 0 2 2 2 1 DENN (AEX-3) domain dDENN PF03455.19 EKE37397.1 - 1e-09 38.3 2.4 1.6e-09 37.6 0.3 2.6 2 0 0 2 2 2 1 dDENN domain uDENN PF03456.18 EKE37397.1 - 3.2e-05 24.6 0.0 6.4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 uDENN domain DUF4852 PF16144.5 EKE37397.1 - 0.53 10.4 4.4 6.2 7.0 0.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4852) Thioredoxin_7 PF13899.6 EKE37398.1 - 0.046 13.9 0.0 0.091 12.9 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin-like Prefoldin_2 PF01920.20 EKE37399.1 - 2.9e-20 72.2 8.6 3.2e-20 72.1 8.6 1.0 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 EKE37399.1 - 6e-06 26.2 5.2 1.4e-05 25.0 0.3 2.1 1 1 0 2 2 2 1 Prefoldin subunit Med9 PF07544.13 EKE37399.1 - 0.0012 18.9 3.0 0.0035 17.4 0.2 2.3 2 1 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 Thioredoxin_14 PF18402.1 EKE37399.1 - 0.0014 18.6 1.7 0.0016 18.4 1.7 1.1 1 0 0 1 1 1 1 Thioredoxin-like domain CdvA PF18822.1 EKE37399.1 - 0.013 15.3 2.6 0.17 11.7 0.4 2.1 2 0 0 2 2 2 0 CdvA-like coiled-coil domain Phage_GP20 PF06810.11 EKE37399.1 - 0.026 14.3 3.9 0.58 9.9 0.2 2.1 2 0 0 2 2 2 0 Phage minor structural protein GP20 Gp-FAR-1 PF05823.12 EKE37399.1 - 0.027 14.9 3.9 0.079 13.3 3.9 1.7 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF948 PF06103.11 EKE37399.1 - 0.079 13.2 3.1 0.3 11.4 0.2 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) SKA1 PF07160.12 EKE37399.1 - 0.11 12.4 7.9 0.043 13.6 1.1 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 DASH_Spc19 PF08287.11 EKE37399.1 - 0.12 12.3 5.1 0.045 13.7 1.1 1.8 1 1 1 2 2 2 0 Spc19 KELK PF15796.5 EKE37399.1 - 0.14 12.6 4.2 2.2 8.8 0.4 2.2 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF4164 PF13747.6 EKE37399.1 - 0.17 12.2 2.1 2.6 8.4 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DASH_Dad3 PF08656.10 EKE37399.1 - 0.18 11.9 3.2 1.3 9.1 0.4 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad3 Snapin_Pallidin PF14712.6 EKE37399.1 - 0.28 11.6 8.5 2.2 8.8 2.2 2.1 1 1 1 2 2 2 0 Snapin/Pallidin FapA PF03961.13 EKE37399.1 - 0.46 9.0 5.3 0.55 8.8 5.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF16 PF01519.16 EKE37399.1 - 6.4 7.3 8.5 66 4.1 8.5 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF16 FNIP PF05725.12 EKE37402.1 - 0.037 14.2 0.7 0.037 14.2 0.7 7.3 7 2 1 8 8 8 0 FNIP Repeat Mitofilin PF09731.9 EKE37403.1 - 0.00038 19.4 38.4 0.00038 19.4 38.4 2.2 2 0 0 2 2 2 1 Mitochondrial inner membrane protein SH PF01445.17 EKE37404.1 - 0.051 13.5 1.9 0.057 13.4 0.1 1.8 1 1 1 2 2 2 0 Viral small hydrophobic protein Ribosomal_L26 PF16906.5 EKE37405.1 - 4.2e-31 107.2 2.0 9.5e-31 106.1 2.0 1.6 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal RhoGEF PF00621.20 EKE37406.1 - 3.5e-21 76.3 8.1 1e-20 74.8 8.1 1.8 1 0 0 1 1 1 1 RhoGEF domain DUF4174 PF13778.6 EKE37406.1 - 0.066 13.7 5.2 4.5 7.8 0.0 3.5 4 1 0 4 4 4 0 Domain of unknown function (DUF4174) GCR1_C PF12550.8 EKE37406.1 - 0.076 13.3 3.2 0.13 12.6 0.5 2.9 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes HALZ PF02183.18 EKE37406.1 - 1 9.6 4.5 5.1 7.4 0.8 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper Maelstrom PF13017.6 EKE37407.1 - 5.7e-38 130.8 2.7 5.7e-38 130.8 2.7 2.2 2 1 0 2 2 2 1 piRNA pathway germ-plasm component RNase_T PF00929.24 EKE37407.1 - 0.0021 18.6 0.5 0.0021 18.6 0.5 3.0 3 2 0 3 3 3 1 Exonuclease VPS28 PF03997.12 EKE37408.1 - 1.6e-05 24.7 0.5 2.7e-05 23.9 0.4 1.5 1 1 0 1 1 1 1 VPS28 protein DUF3991 PF13154.6 EKE37408.1 - 0.066 13.6 0.8 0.11 12.8 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3991) Porin_4 PF13609.6 EKE37409.1 - 7.2e-05 22.7 9.2 7.2e-05 22.7 9.2 4.5 1 1 4 5 5 5 3 Gram-negative porin BBP2 PF07642.11 EKE37409.1 - 0.0042 16.3 14.9 0.0042 16.3 14.9 5.7 1 1 2 3 3 3 2 Putative beta-barrel porin-2, OmpL-like. bbp2 Lipocalin_2 PF08212.12 EKE37409.1 - 1.5 8.7 13.0 3.5 7.5 0.6 3.9 3 1 1 4 4 4 0 Lipocalin-like domain LRR_5 PF13306.6 EKE37410.1 - 8.8e-21 74.2 24.1 8.9e-14 51.6 7.9 3.7 1 1 2 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE37410.1 - 0.023 14.5 4.7 3.4 7.5 0.2 4.0 2 1 4 6 6 6 0 Leucine rich repeat Glyco_hydro_14 PF01373.17 EKE37411.1 - 7.1e-108 361.1 7.7 8.2e-108 360.9 7.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 Glyco_hydro_42 PF02449.15 EKE37411.1 - 0.098 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Beta-galactosidase DUF3781 PF12636.7 EKE37413.1 - 0.17 11.8 0.3 0.17 11.8 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3781) E1-E2_ATPase PF00122.20 EKE37414.1 - 2.8e-20 72.6 0.7 2.8e-20 72.6 0.7 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 EKE37414.1 - 6.3e-15 54.6 0.0 1.5e-14 53.4 0.0 1.6 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus DUF5336 PF17270.2 EKE37414.1 - 0.077 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5336) DUF3537 PF12056.8 EKE37414.1 - 0.088 11.6 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) LRR_5 PF13306.6 EKE37415.1 - 1.1e-219 717.3 155.9 1.3e-33 115.7 19.1 9.6 4 4 4 9 9 9 9 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE37415.1 - 6.2e-40 134.8 15.4 0.00054 19.7 0.1 19.4 12 5 15 27 27 27 17 Leucine rich repeat PhrC_PhrF PF11131.8 EKE37415.1 - 0.26 10.9 1.1 0.78 9.4 1.1 1.9 1 0 0 1 1 1 0 Rap-phr extracellular signalling LRR_4 PF12799.7 EKE37415.1 - 0.98 9.9 50.4 0.51 10.8 1.1 14.3 12 4 2 14 14 14 0 Leucine Rich repeats (2 copies) PTCB-BRCT PF12738.7 EKE37416.1 - 1.2e-07 31.6 0.2 3e-07 30.3 0.1 1.8 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.26 EKE37416.1 - 0.0011 19.3 3.2 0.0073 16.7 0.3 3.1 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain TetR PF13972.6 EKE37416.1 - 0.0079 15.9 1.6 0.02 14.6 0.9 1.9 1 1 1 2 2 2 1 Bacterial transcriptional repressor TipAS PF07739.13 EKE37416.1 - 2 9.0 8.4 1 9.9 5.5 2.0 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain SPRY PF00622.28 EKE37417.1 - 6.7e-14 52.0 0.7 1e-13 51.4 0.7 1.3 1 0 0 1 1 1 1 SPRY domain DUF357 PF04010.13 EKE37418.1 - 0.62 10.2 1.9 0.98 9.5 0.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF357) Asp-B-Hydro_N PF05279.11 EKE37418.1 - 4.2 7.4 25.0 5.4 7.0 25.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Arm-DNA-bind_4 PF14657.6 EKE37418.1 - 6.7 6.6 11.0 12 5.7 2.6 3.0 3 0 0 3 3 3 0 Arm DNA-binding domain Pkinase PF00069.25 EKE37419.1 - 2.6e-25 89.3 0.1 3.2e-25 89.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37419.1 - 3.7e-15 55.9 0.0 4.7e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37419.1 - 8.2e-09 34.7 0.1 1.1e-08 34.3 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase ABC1 PF03109.16 EKE37419.1 - 0.012 15.7 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 ABC1 family APH PF01636.23 EKE37419.1 - 0.087 12.7 0.0 0.17 11.8 0.0 1.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ribosomal_L14e PF01929.17 EKE37420.1 - 2.3e-19 69.7 0.9 3.1e-19 69.2 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EKE37420.1 - 0.0033 17.3 0.0 0.0081 16.1 0.0 1.6 1 0 0 1 1 1 1 KOW motif RhoGEF PF00621.20 EKE37423.1 - 1.1e-26 94.2 8.4 1.1e-26 94.2 8.4 2.4 3 0 0 3 3 3 1 RhoGEF domain IQ PF00612.27 EKE37423.1 - 0.0098 15.6 0.1 0.024 14.4 0.1 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF4088 PF13317.6 EKE37424.1 - 0.093 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) DUF2087 PF09860.9 EKE37424.1 - 0.15 12.2 0.0 0.4 10.9 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) LRR_5 PF13306.6 EKE37425.1 - 1.2e-43 148.1 5.2 7.8e-29 100.2 7.7 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE37425.1 - 0.0006 19.5 0.0 0.49 10.2 0.1 3.9 1 1 4 5 5 5 3 Leucine rich repeat NUDIX PF00293.28 EKE37426.1 - 6.4e-21 74.8 0.0 7.9e-21 74.5 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain zinc_ribbon_13 PF09855.9 EKE37426.1 - 0.033 14.4 1.6 6 7.1 0.1 2.4 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Zn_Tnp_IS91 PF14319.6 EKE37426.1 - 0.058 13.4 0.3 0.092 12.8 0.3 1.2 1 0 0 1 1 1 0 Transposase zinc-binding domain zf-tcix PF14952.6 EKE37426.1 - 0.11 12.1 0.6 7.2 6.3 0.1 2.3 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding zf-ribbon_3 PF13248.6 EKE37426.1 - 0.12 11.9 2.5 0.16 11.5 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2_3 PF13878.6 EKE37426.1 - 0.15 11.9 1.5 0.89 9.4 0.1 2.3 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zinc_ribbon_2 PF13240.6 EKE37426.1 - 0.2 11.4 0.5 0.2 11.4 0.5 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF3797 PF12677.7 EKE37426.1 - 0.24 11.3 4.4 8 6.4 4.5 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) Ribosomal_L37e PF01907.19 EKE37426.1 - 0.35 11.1 2.8 0.73 10.0 2.8 1.5 1 0 0 1 1 1 0 Ribosomal protein L37e CBFB_NFYA PF02045.15 EKE37427.1 - 4.5e-21 75.2 8.0 6.7e-21 74.7 8.0 1.3 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B UCMA PF17085.5 EKE37427.1 - 0.048 13.7 2.9 0.074 13.1 2.9 1.3 1 0 0 1 1 1 0 Unique cartilage matrix associated protein VPS9 PF02204.18 EKE37428.1 - 0.0038 17.4 1.5 0.0096 16.1 0.4 2.2 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain DUF818 PF05677.12 EKE37429.1 - 0.00099 18.2 0.0 0.0017 17.4 0.0 1.3 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) SAM_2 PF07647.17 EKE37429.1 - 0.004 17.2 0.2 0.042 13.9 0.1 2.6 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) Ndr PF03096.14 EKE37429.1 - 0.02 13.6 0.0 0.034 12.9 0.0 1.3 1 0 0 1 1 1 0 Ndr family SAM_1 PF00536.30 EKE37429.1 - 0.073 13.5 0.3 0.17 12.4 0.1 1.8 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) SNARE PF05739.19 EKE37430.1 - 2e-08 34.1 0.1 3.6e-08 33.3 0.1 1.4 1 0 0 1 1 1 1 SNARE domain RIFIN PF02009.16 EKE37430.1 - 0.0069 16.3 1.5 0.0084 16.0 1.5 1.0 1 0 0 1 1 1 1 Rifin Maf PF02545.14 EKE37430.1 - 0.014 15.3 0.3 0.017 15.0 0.3 1.1 1 0 0 1 1 1 0 Maf-like protein Orf78 PF06024.12 EKE37430.1 - 0.15 12.4 5.2 0.46 10.8 5.2 1.8 1 1 0 1 1 1 0 Orf78 (ac78) Pkinase PF00069.25 EKE37432.1 - 1.6e-52 178.5 0.6 1.9e-52 178.2 0.6 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37432.1 - 1.4e-31 109.7 0.1 1.8e-31 109.3 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE37432.1 - 5.5e-05 22.6 0.0 0.00045 19.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EKE37432.1 - 0.003 17.5 0.0 0.0053 16.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EKE37432.1 - 0.0069 15.4 0.1 0.0069 15.4 0.1 2.1 3 0 0 3 3 3 1 Poxvirus serine/threonine protein kinase FTA2 PF13095.6 EKE37432.1 - 0.048 13.3 0.1 0.53 9.9 0.0 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EKE37432.1 - 0.13 11.8 0.1 0.25 10.9 0.1 1.5 1 1 0 1 1 1 0 RIO1 family Kdo PF06293.14 EKE37432.1 - 0.17 11.2 0.1 0.45 9.8 0.1 1.8 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PTPLA PF04387.14 EKE37434.1 - 4.4e-49 166.4 10.0 7.4e-49 165.6 10.0 1.4 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA HEAT_EZ PF13513.6 EKE37435.1 - 0.0064 17.0 0.4 0.6 10.7 0.1 3.8 3 0 0 3 3 3 1 HEAT-like repeat RIX1 PF08167.12 EKE37435.1 - 0.019 14.7 10.4 0.35 10.6 0.5 5.3 3 2 2 6 6 6 0 rRNA processing/ribosome biogenesis UNC45-central PF11701.8 EKE37435.1 - 0.7 9.8 6.1 4.8 7.1 0.4 4.2 3 2 1 5 5 5 0 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 EKE37435.1 - 0.71 9.4 5.7 0.87 9.1 0.5 3.2 3 1 0 3 3 3 0 CLASP N terminal LRR_5 PF13306.6 EKE37436.1 - 1.2e-134 442.4 112.5 1.1e-27 96.5 10.7 6.9 3 2 3 7 7 7 7 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE37436.1 - 6.9e-29 99.4 2.9 0.0014 18.3 0.0 11.1 5 4 8 13 13 13 12 Leucine rich repeat LRR_4 PF12799.7 EKE37436.1 - 0.085 13.3 32.0 4.2 7.9 0.0 10.0 5 4 2 8 8 8 0 Leucine Rich repeats (2 copies) Xpo1 PF08389.12 EKE37437.1 - 0.081 13.0 0.2 0.1 12.7 0.2 1.2 1 0 0 1 1 1 0 Exportin 1-like protein zf-C3HC4_3 PF13920.6 EKE37439.1 - 1.3e-15 56.9 17.1 1.3e-15 56.9 17.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE37439.1 - 9.3e-07 28.6 16.1 9.3e-07 28.6 16.1 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EKE37439.1 - 0.014 15.7 17.9 0.014 15.7 17.9 2.3 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 EKE37439.1 - 0.014 15.3 17.0 0.014 15.3 17.0 2.2 3 0 0 3 3 3 0 zinc-RING finger domain TerY_C PF15616.6 EKE37439.1 - 0.54 10.4 16.1 0.39 10.8 0.6 2.1 2 0 0 2 2 2 0 TerY-C metal binding domain EI24 PF07264.11 EKE37440.1 - 1.8e-05 25.1 8.6 1.8e-05 25.1 8.6 2.0 1 1 1 2 2 2 1 Etoposide-induced protein 2.4 (EI24) DDE_Tnp_IS66_C PF13817.6 EKE37440.1 - 0.049 13.9 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 IS66 C-terminal element A_deaminase PF00962.22 EKE37441.1 - 1.4e-149 497.9 0.1 4e-85 286.0 0.0 2.3 2 0 0 2 2 2 2 Adenosine/AMP deaminase zf-B_box PF00643.24 EKE37441.1 - 3.2e-05 24.0 7.7 9.1e-05 22.5 7.7 1.8 1 0 0 1 1 1 1 B-box zinc finger IBR PF01485.21 EKE37441.1 - 0.002 18.3 2.9 0.002 18.3 2.9 2.0 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain DUF1858 PF08984.11 EKE37441.1 - 0.058 13.6 0.1 31 4.8 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1858) GAGA_bind PF06217.12 EKE37442.1 - 0.57 10.4 9.2 0.63 10.3 9.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family BUD22 PF09073.10 EKE37442.1 - 1.9 7.7 31.9 2.2 7.5 31.9 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 EKE37442.1 - 3.5 5.7 37.5 3.9 5.6 37.5 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EKE37442.1 - 8.4 4.5 30.6 9.3 4.4 30.6 1.1 1 0 0 1 1 1 0 CDC45-like protein FHA PF00498.26 EKE37443.1 - 1.1e-13 51.3 0.1 1.8e-13 50.6 0.1 1.3 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EKE37443.1 - 3.4e-06 27.3 0.0 5.2e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Cu-oxidase_2 PF07731.14 EKE37443.1 - 0.046 13.5 0.7 0.057 13.2 0.1 1.5 1 1 0 1 1 1 0 Multicopper oxidase TLD PF07534.16 EKE37444.1 - 1.5e-05 25.2 0.8 2.7e-05 24.4 0.8 1.4 1 0 0 1 1 1 1 TLD ATG11 PF10377.9 EKE37444.1 - 0.24 11.4 5.7 0.062 13.4 2.1 1.9 1 1 1 2 2 2 0 Autophagy-related protein 11 DUF1492 PF07374.11 EKE37444.1 - 0.84 9.8 9.2 0.6 10.3 6.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1492) Vps4_C PF09336.10 EKE37445.1 - 0.013 15.5 0.1 1.6 8.8 0.0 2.5 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain CBS PF00571.28 EKE37445.1 - 0.077 13.4 0.3 23 5.6 0.0 2.9 3 0 0 3 3 3 0 CBS domain AMP-binding PF00501.28 EKE37446.1 - 2.7e-70 237.1 0.0 3.5e-70 236.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EKE37446.1 - 1.1e-05 26.3 0.0 2.4e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Peptidase_C32 PF05411.12 EKE37446.1 - 0.023 14.6 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 Equine arteritis virus putative proteinase Xpo1 PF08389.12 EKE37447.1 - 1.7e-12 47.6 2.0 1.7e-12 47.6 2.0 3.4 3 0 0 3 3 3 1 Exportin 1-like protein Herpes_VP19C PF03327.14 EKE37447.1 - 0.091 12.2 0.1 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Herpesvirus capsid shell protein VP19C CPSF_A PF03178.15 EKE37449.1 - 4.8e-35 121.4 2.5 2.1e-34 119.3 0.4 2.9 3 0 0 3 3 3 1 CPSF A subunit region DSRB PF10781.9 EKE37449.1 - 0.018 14.7 0.0 0.071 12.8 0.0 2.0 1 0 0 1 1 1 0 Dextransucrase DSRB PQQ_3 PF13570.6 EKE37449.1 - 0.089 13.3 0.0 22 5.7 0.1 3.4 4 0 0 4 4 4 0 PQQ-like domain RVT_thumb PF06817.14 EKE37449.1 - 0.11 12.3 0.3 0.63 9.9 0.2 2.3 2 0 0 2 2 2 0 Reverse transcriptase thumb domain PGBA_N PF15436.6 EKE37450.1 - 0.017 14.8 1.1 0.047 13.3 0.5 2.1 1 1 1 2 2 2 0 Plasminogen-binding protein pgbA N-terminal CspB_prodomain PF18425.1 EKE37450.1 - 0.034 14.1 0.2 0.11 12.5 0.2 1.8 1 0 0 1 1 1 0 Csp protease B prodomain C1_2 PF03107.16 EKE37450.1 - 0.38 11.1 13.2 0.94 9.8 13.2 1.7 1 0 0 1 1 1 0 C1 domain C1_1 PF00130.22 EKE37450.1 - 7.1 6.6 15.1 18 5.3 15.1 1.8 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RhoGAP PF00620.27 EKE37451.1 - 1.4e-17 64.0 0.3 4.7e-17 62.2 0.3 1.9 1 0 0 1 1 1 1 RhoGAP domain ANAPC4_WD40 PF12894.7 EKE37451.1 - 0.0011 19.2 0.5 0.029 14.6 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain C1_1 PF00130.22 EKE37451.1 - 0.015 15.2 16.2 0.036 13.9 16.2 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_13 PF18335.1 EKE37451.1 - 0.029 14.2 1.5 1.2 9.0 0.2 3.4 2 0 0 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain Zn_ribbon_17 PF17120.5 EKE37451.1 - 1.7 8.3 14.1 3.7 7.2 14.1 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DUF4234 PF14018.6 EKE37453.1 - 0.14 12.3 4.1 0.35 11.0 1.3 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4234) Myotub-related PF06602.14 EKE37454.1 - 1e-102 343.7 1.5 2e-102 342.8 1.5 1.4 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 EKE37454.1 - 0.0086 15.9 0.6 0.032 14.1 0.1 2.2 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PH PF00169.29 EKE37454.1 - 0.022 15.3 0.1 0.26 11.8 0.0 2.7 2 0 0 2 2 2 0 PH domain Y_phosphatase PF00102.27 EKE37454.1 - 0.031 13.9 0.0 0.089 12.3 0.0 1.7 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EKE37454.1 - 0.041 13.9 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family PH PF00169.29 EKE37456.1 - 3.2e-12 46.9 0.1 6.7e-12 45.8 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EKE37456.1 - 0.014 15.8 1.4 0.036 14.5 1.4 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain RRM_1 PF00076.22 EKE37457.1 - 3.9e-07 29.8 0.1 8.8e-07 28.7 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 EKE37457.1 - 0.00051 19.9 0.0 0.001 18.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Bac_A_amyl_C PF18612.1 EKE37457.1 - 0.075 12.8 0.4 1.7 8.5 0.0 2.6 3 0 0 3 3 3 0 Bacterial Alpha amylase C-terminal domain PQQ_2 PF13360.6 EKE37457.1 - 0.25 10.9 0.0 1.1 8.8 0.0 2.0 2 0 0 2 2 2 0 PQQ-like domain LSM PF01423.22 EKE37458.1 - 0.0016 18.1 0.0 0.0018 17.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain Ribophorin_II PF05817.14 EKE37459.1 - 1.3 7.5 13.0 1.4 7.4 13.0 1.1 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II MIG-14_Wnt-bd PF06664.12 EKE37460.1 - 4.8e-54 183.6 50.1 6.4e-54 183.1 50.1 1.2 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion DUF2976 PF11190.8 EKE37460.1 - 1.7 8.5 6.7 0.19 11.5 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) zf-C2H2_4 PF13894.6 EKE37461.1 - 6e-05 23.5 1.7 0.02 15.7 0.0 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EKE37461.1 - 0.00016 21.9 1.4 0.013 15.9 0.0 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-Di19 PF05605.12 EKE37461.1 - 0.00046 20.4 3.0 0.005 17.1 0.1 2.6 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 EKE37461.1 - 0.012 15.4 2.3 7.6 6.5 0.0 3.4 3 1 0 3 3 3 0 Rad50 zinc hook motif zf-BED PF02892.15 EKE37461.1 - 0.046 13.7 1.5 1.6 8.8 0.2 2.9 2 1 1 3 3 3 0 BED zinc finger PRP21_like_P PF12230.8 EKE37461.1 - 0.054 13.4 7.1 0.2 11.5 7.1 1.9 1 1 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein DUF1610 PF07754.11 EKE37461.1 - 0.056 13.4 1.2 0.11 12.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) YabA PF06156.13 EKE37461.1 - 0.081 13.6 6.8 0.12 13.0 6.8 1.4 1 0 0 1 1 1 0 Initiation control protein YabA OTT_1508_deam PF14441.6 EKE37461.1 - 0.15 12.1 0.7 22 5.2 0.0 2.7 2 1 0 2 2 2 0 OTT_1508-like deaminase Glyco_transf_41 PF13844.6 EKE37461.1 - 2.1 6.7 5.5 2.4 6.5 5.5 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 Proteasome PF00227.26 EKE37462.1 - 2e-44 151.4 0.0 2.2e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Lipase_3 PF01764.25 EKE37463.1 - 1.3e-05 25.1 0.1 2.5e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 Lipase (class 3) PH PF00169.29 EKE37464.1 - 0.00099 19.6 0.2 0.0023 18.4 0.2 1.7 1 0 0 1 1 1 1 PH domain Na_Ca_ex PF01699.24 EKE37464.1 - 0.23 11.4 41.9 0.02 14.8 14.8 2.5 2 0 0 2 2 2 0 Sodium/calcium exchanger protein DUF1218 PF06749.12 EKE37464.1 - 6.5 7.3 16.8 23 5.6 0.1 4.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1218) Pkinase PF00069.25 EKE37465.1 - 5.7e-54 183.2 0.0 9.6e-54 182.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37465.1 - 8e-54 182.6 0.0 1.1e-53 182.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37465.1 - 1.9e-06 26.9 0.0 3.7e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE37465.1 - 0.0031 16.9 0.0 0.0052 16.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family BSP_II PF05432.11 EKE37465.1 - 0.14 11.8 5.4 0.24 11.1 5.4 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) EB PF01683.18 EKE37465.1 - 1 9.7 4.5 0.48 10.8 2.0 1.7 2 0 0 2 2 2 0 EB module VHS PF00790.19 EKE37466.1 - 6.4e-07 29.3 0.9 2.6e-06 27.4 0.0 2.4 3 1 0 3 3 3 1 VHS domain Cyclin_C PF02984.19 EKE37466.1 - 0.033 14.3 0.3 0.11 12.6 0.3 1.8 1 0 0 1 1 1 0 Cyclin, C-terminal domain Peptidase_M57 PF12388.8 EKE37466.1 - 0.045 13.4 0.0 0.098 12.2 0.0 1.6 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase RNase_J_C PF17770.1 EKE37466.1 - 0.93 10.6 3.5 1.6 9.8 0.6 2.8 3 0 0 3 3 3 0 Ribonuclease J C-terminal domain Vps53_N PF04100.12 EKE37467.1 - 1.7e-42 145.7 17.9 1.5e-38 132.8 7.7 2.7 3 0 0 3 3 3 2 Vps53-like, N-terminal DUF2451 PF10474.9 EKE37467.1 - 2.7e-07 30.6 0.9 2.7e-07 30.6 0.9 3.1 3 0 0 3 3 3 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 EKE37467.1 - 0.002 17.5 8.7 0.002 17.5 8.7 2.0 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Mce4_CUP1 PF11887.8 EKE37467.1 - 0.01 15.3 0.9 0.021 14.3 0.2 1.8 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Interferon PF00143.19 EKE37467.1 - 0.029 14.6 9.0 0.97 9.6 1.3 3.4 2 1 1 3 3 3 0 Interferon alpha/beta domain DIL PF01843.19 EKE37467.1 - 0.089 13.1 0.3 0.55 10.5 0.1 2.6 2 0 0 2 2 2 0 DIL domain CBFD_NFYB_HMF PF00808.23 EKE37467.1 - 0.11 12.9 0.1 0.36 11.1 0.1 2.0 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Vps51 PF08700.11 EKE37467.1 - 1.1 9.3 8.3 0.15 12.1 1.2 3.3 3 0 0 3 3 3 0 Vps51/Vps67 Cas_Csy3 PF09615.10 EKE37467.1 - 3.4 6.9 7.0 6.9 5.9 0.9 2.9 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Csy3) RNase_PH PF01138.21 EKE37468.1 - 3.1e-21 76.3 0.0 5e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EKE37468.1 - 2.9e-08 33.6 0.2 6.9e-08 32.4 0.2 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Rotamase PF00639.21 EKE37469.1 - 5.8e-20 72.1 0.1 6.9e-20 71.8 0.1 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EKE37469.1 - 1.9e-12 47.7 0.0 2.2e-12 47.5 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EKE37469.1 - 0.00012 22.8 0.0 0.00016 22.5 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain TLD PF07534.16 EKE37470.1 - 0.0034 17.6 0.9 0.0091 16.2 0.9 1.7 1 0 0 1 1 1 1 TLD Myotub-related PF06602.14 EKE37471.1 - 1.4e-83 280.7 0.7 2.8e-83 279.8 0.7 1.4 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Phosphoesterase PF04185.14 EKE37472.1 - 0.17 11.0 0.0 0.72 9.0 0.0 1.8 2 0 0 2 2 2 0 Phosphoesterase family DUF1474 PF07342.11 EKE37472.1 - 0.43 11.1 2.6 2.9 8.5 0.4 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1474) RhoGEF PF00621.20 EKE37473.1 - 1.4e-06 28.7 13.6 1.4e-06 28.7 13.6 2.1 2 0 0 2 2 2 1 RhoGEF domain LSM PF01423.22 EKE37474.1 - 6.5e-18 64.2 1.8 7.7e-18 63.9 1.8 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EKE37474.1 - 0.00052 20.1 0.2 0.0006 19.9 0.2 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain Got1 PF04178.12 EKE37475.1 - 7.4e-26 90.8 19.3 1e-25 90.3 19.3 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family Myb_DNA-binding PF00249.31 EKE37476.1 - 7.7e-05 22.8 0.0 0.00031 20.9 0.0 1.9 1 1 0 1 1 1 1 Myb-like DNA-binding domain Tet_JBP PF12851.7 EKE37476.1 - 0.048 13.0 0.0 0.053 12.9 0.0 1.1 1 0 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily G6PD_N PF00479.22 EKE37477.1 - 0.024 15.3 0.1 0.031 14.9 0.1 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain PARP PF00644.20 EKE37478.1 - 9e-16 58.0 1.1 2.6e-13 50.0 0.2 2.3 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain zf-CCHH PF10283.9 EKE37478.1 - 3.4e-06 26.9 0.8 7.9e-06 25.8 0.8 1.7 1 0 0 1 1 1 1 PBZ domain Ribosomal_S27e PF01667.17 EKE37479.1 - 0.22 11.3 1.7 0.41 10.4 0.9 1.8 2 0 0 2 2 2 0 Ribosomal protein S27 RGS PF00615.19 EKE37480.1 - 9.7e-15 54.9 5.0 9.7e-15 54.9 5.0 3.8 3 1 0 3 3 3 1 Regulator of G protein signaling domain RGS-like PF09128.11 EKE37480.1 - 0.0022 17.7 0.6 0.01 15.5 0.3 2.3 2 0 0 2 2 2 1 Regulator of G protein signalling-like domain DUF155 PF02582.14 EKE37480.1 - 1.1 9.4 9.6 9 6.4 0.2 3.4 3 1 0 3 3 3 0 Uncharacterised ACR, YagE family COG1723 SWIM PF04434.17 EKE37481.1 - 1.8e-07 30.7 0.8 1.8e-07 30.7 0.8 2.3 2 0 0 2 2 2 1 SWIM zinc finger SEA PF01390.20 EKE37481.1 - 0.11 12.6 2.6 2.9 8.0 0.0 2.4 2 0 0 2 2 2 0 SEA domain HTH_33 PF13592.6 EKE37481.1 - 0.2 11.4 0.0 0.41 10.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix IPPT PF01715.17 EKE37482.1 - 2e-56 191.4 2.1 3.6e-56 190.5 2.1 1.4 1 0 0 1 1 1 1 IPP transferase zf-met PF12874.7 EKE37482.1 - 2.8e-07 30.7 0.1 6.2e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EKE37482.1 - 3.2e-07 30.4 0.6 9.4e-07 29.0 0.6 1.9 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding AAA_33 PF13671.6 EKE37482.1 - 3.3e-07 30.6 0.0 1.1e-05 25.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain IPT PF01745.16 EKE37482.1 - 6.4e-07 29.0 0.4 3.4e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 Isopentenyl transferase AAA_18 PF13238.6 EKE37482.1 - 0.00058 20.4 0.1 0.1 13.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain SKI PF01202.22 EKE37482.1 - 0.00068 19.8 2.0 3.7 7.6 0.0 3.4 3 0 0 3 3 3 1 Shikimate kinase KTI12 PF08433.10 EKE37482.1 - 0.0013 18.3 2.0 0.17 11.3 0.0 2.3 2 0 0 2 2 2 1 Chromatin associated protein KTI12 PRK PF00485.18 EKE37482.1 - 0.0017 18.1 0.9 0.026 14.3 0.0 2.8 3 0 0 3 3 3 1 Phosphoribulokinase / Uridine kinase family AAA_22 PF13401.6 EKE37482.1 - 0.0018 18.6 0.0 0.016 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EKE37482.1 - 0.0039 16.5 0.0 0.008 15.5 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 EKE37482.1 - 0.0079 16.6 0.0 0.037 14.4 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 EKE37482.1 - 0.01 14.9 0.1 0.038 13.0 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein RNA_pol_Rpb1_3 PF04983.18 EKE37482.1 - 0.011 15.7 0.7 0.024 14.6 0.7 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 3 Cytidylate_kin PF02224.18 EKE37482.1 - 0.012 15.3 0.1 0.048 13.4 0.0 2.1 2 1 1 3 3 3 0 Cytidylate kinase RNA_helicase PF00910.22 EKE37482.1 - 0.016 15.6 0.2 0.11 12.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase Fer4_16 PF13484.6 EKE37482.1 - 0.035 15.0 1.3 0.17 12.9 1.3 2.2 1 0 0 1 1 1 0 4Fe-4S double cluster binding domain AAA PF00004.29 EKE37482.1 - 0.04 14.4 0.1 0.31 11.5 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EKE37482.1 - 0.068 13.2 0.0 0.068 13.2 0.0 2.7 3 0 0 3 3 3 0 AAA domain zf-U1 PF06220.12 EKE37482.1 - 0.087 12.6 0.6 0.19 11.5 0.6 1.6 1 0 0 1 1 1 0 U1 zinc finger APS_kinase PF01583.20 EKE37482.1 - 0.14 12.1 0.1 0.43 10.5 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase MMR_HSR1 PF01926.23 EKE37482.1 - 0.15 12.2 2.1 0.39 10.8 0.1 2.6 3 1 0 3 3 3 0 50S ribosome-binding GTPase CoaE PF01121.20 EKE37482.1 - 0.16 11.6 1.9 0.22 11.2 0.1 2.0 2 0 0 2 2 2 0 Dephospho-CoA kinase ABC_tran PF00005.27 EKE37482.1 - 2.5 8.6 8.0 17 5.9 8.0 2.5 1 1 0 1 1 1 0 ABC transporter Dynamin_N PF00350.23 EKE37482.1 - 7.7 6.6 7.5 0.74 9.9 0.1 2.6 3 1 0 3 3 2 0 Dynamin family GTP_EFTU PF00009.27 EKE37484.1 - 2.6e-53 180.5 0.5 4.6e-53 179.7 0.5 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EKE37484.1 - 1.8e-17 63.2 0.0 4.7e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EKE37484.1 - 3e-08 33.6 0.0 7.5e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 EKE37484.1 - 3.8e-06 26.7 0.0 2.4e-05 24.1 0.0 2.3 2 0 0 2 2 2 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 EKE37484.1 - 9.5e-06 25.9 0.0 2.4e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EKE37484.1 - 0.0032 17.5 0.0 0.01 15.9 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase START PF01852.19 EKE37487.1 - 1.1e-24 87.0 0.3 1.5e-24 86.6 0.3 1.1 1 0 0 1 1 1 1 START domain TLD PF07534.16 EKE37492.1 - 1.2e-06 28.8 5.6 1.5e-06 28.5 5.6 1.0 1 0 0 1 1 1 1 TLD SUKH_6 PF14568.6 EKE37492.1 - 0.0021 18.5 0.8 0.0034 17.8 0.5 1.5 1 1 1 2 2 2 1 SMI1-KNR4 cell-wall Peptidase_C48 PF02902.19 EKE37493.1 - 1.5e-07 31.5 2.9 1.2e-06 28.5 2.9 2.0 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain SNF2_N PF00176.23 EKE37494.1 - 1.8e-57 194.7 0.4 1.8e-57 194.7 0.4 2.0 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE37494.1 - 1.6e-17 63.8 0.1 6e-17 62.0 0.1 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE37494.1 - 3.1e-12 46.8 1.0 3.5e-10 40.1 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EKE37494.1 - 1.3e-06 28.3 0.4 2.1e-05 24.3 0.0 2.5 2 0 0 2 2 2 1 SWI2/SNF2 ATPase AAA_34 PF13872.6 EKE37494.1 - 1.9e-05 23.7 0.0 0.00011 21.2 0.0 2.1 2 1 0 2 2 2 1 P-loop containing NTP hydrolase pore-1 DUF2439 PF10382.9 EKE37494.1 - 0.0013 19.0 0.0 0.0013 19.0 0.0 3.4 4 1 0 4 4 4 1 Protein of unknown function (DUF2439) N2227 PF07942.12 EKE37495.1 - 8.2e-43 146.5 0.7 1.2e-42 146.0 0.7 1.2 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 EKE37495.1 - 0.0016 19.0 0.0 0.063 13.9 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE37495.1 - 0.013 16.2 0.0 2.8 8.7 0.0 2.8 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 EKE37495.1 - 0.014 15.1 1.5 0.028 14.2 0.0 2.2 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_12 PF08242.12 EKE37495.1 - 0.031 15.0 0.0 0.072 13.8 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Ribosomal_L37ae PF01780.19 EKE37496.1 - 3.2e-39 132.9 8.2 3.6e-39 132.7 8.2 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 EKE37496.1 - 0.0034 17.3 7.1 0.0052 16.7 7.1 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-RING_13 PF17977.1 EKE37496.1 - 0.015 15.4 4.2 0.021 14.9 4.2 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain A2L_zn_ribbon PF08792.10 EKE37496.1 - 0.094 12.5 5.9 2.5 7.9 0.7 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-H2C2_2 PF13465.6 EKE37496.1 - 0.19 12.2 2.7 2 9.0 1.1 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zf-BED PF02892.15 EKE37496.1 - 0.32 11.0 7.5 0.49 10.4 0.9 2.2 1 1 1 2 2 2 0 BED zinc finger Arrestin_N PF00339.29 EKE37498.1 - 1.4e-14 54.3 0.1 3.9e-14 52.9 0.1 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain C2 PF00168.30 EKE37498.1 - 3.8e-11 43.2 0.1 1.1e-10 41.7 0.1 1.9 1 0 0 1 1 1 1 C2 domain WW PF00397.26 EKE37498.1 - 2.5e-09 37.1 4.6 2.3e-06 27.6 2.0 2.9 2 0 0 2 2 2 2 WW domain Arrestin_C PF02752.22 EKE37498.1 - 0.0039 17.6 1.7 0.065 13.7 0.3 2.5 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 EKE37498.1 - 0.018 14.8 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Arrestin_N terminal like Rgp1 PF08737.10 EKE37498.1 - 0.11 11.6 0.5 0.83 8.7 0.1 2.3 2 0 0 2 2 2 0 Rgp1 TLD PF07534.16 EKE37500.1 - 2.9e-07 30.8 0.4 4.9e-07 30.1 0.4 1.3 1 0 0 1 1 1 1 TLD FAM195 PF14799.6 EKE37500.1 - 0.016 15.6 2.5 0.016 15.6 2.5 1.6 2 0 0 2 2 2 0 FAM195 family BNIP3 PF06553.12 EKE37500.1 - 0.075 12.7 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 BNIP3 HTH_32 PF13565.6 EKE37501.1 - 1.5e-08 35.1 0.0 2.8e-07 31.0 0.0 2.5 2 1 1 3 3 3 1 Homeodomain-like domain HTH_23 PF13384.6 EKE37501.1 - 1.3e-06 28.0 0.1 5.8e-06 25.9 0.0 2.1 3 0 0 3 3 3 1 Homeodomain-like domain HTH_38 PF13936.6 EKE37501.1 - 5.3e-05 22.9 0.1 0.00035 20.3 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.6 EKE37501.1 - 0.00019 21.5 0.0 0.0033 17.5 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain Linker_histone PF00538.19 EKE37501.1 - 0.0003 21.1 1.3 1.5 9.2 0.0 3.2 3 0 0 3 3 3 2 linker histone H1 and H5 family CENP-B_N PF04218.13 EKE37501.1 - 0.00032 20.3 0.0 0.00068 19.2 0.0 1.5 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain DDE_3 PF13358.6 EKE37501.1 - 0.00067 19.4 0.1 0.0019 17.9 0.1 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_29 PF13551.6 EKE37501.1 - 0.003 17.6 0.0 0.0091 16.0 0.0 1.9 1 0 0 1 1 1 1 Winged helix-turn helix HTH_40 PF14493.6 EKE37501.1 - 0.019 15.4 0.1 0.059 13.8 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 EKE37501.1 - 0.021 15.1 0.0 0.058 13.7 0.0 1.7 1 0 0 1 1 1 0 Transposase HTH_11 PF08279.12 EKE37501.1 - 0.026 14.5 0.0 0.15 12.0 0.0 2.2 2 0 0 2 2 2 0 HTH domain HU-DNA_bdg PF14848.6 EKE37501.1 - 0.09 12.8 0.1 0.21 11.6 0.1 1.6 1 0 0 1 1 1 0 DNA-binding domain Sigma70_r4_2 PF08281.12 EKE37501.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 GerE PF00196.19 EKE37501.1 - 0.11 12.0 0.1 0.71 9.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family PTCB-BRCT PF12738.7 EKE37502.1 - 4.3e-19 68.2 0.0 5.3e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EKE37502.1 - 1.8e-11 44.3 0.0 2.1e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EKE37502.1 - 6.2e-06 26.5 0.0 7.3e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 EKE37502.1 - 0.016 15.3 0.0 0.017 15.2 0.0 1.2 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EKE37503.1 - 2.8e-14 52.8 0.0 3.6e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EKE37503.1 - 4.2e-13 49.5 0.0 5.7e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EKE37503.1 - 7.4e-09 35.9 0.0 9e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EKE37503.1 - 0.001 18.9 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EKE37503.1 - 0.0058 16.7 0.0 0.0063 16.6 0.0 1.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RRM_1 PF00076.22 EKE37504.1 - 9.2e-14 51.0 0.1 1.5e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKE37504.1 - 1.6e-05 24.5 0.0 2.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKE37504.1 - 0.0062 16.4 0.0 0.0097 15.7 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif HAD_2 PF13419.6 EKE37505.1 - 8.8e-22 78.0 3.5 1.1e-21 77.7 3.5 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKE37505.1 - 8.1e-07 29.5 0.0 1.3e-05 25.6 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NIF PF03031.18 EKE37505.1 - 3.5e-06 26.9 1.3 1.9e-05 24.5 1.3 2.0 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase UPF0302 PF08864.10 EKE37505.1 - 0.0075 16.3 1.2 0.015 15.4 0.4 2.0 2 0 0 2 2 2 1 UPF0302 domain Hydrolase_like PF13242.6 EKE37505.1 - 0.017 15.2 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like GIY-YIG PF01541.24 EKE37506.1 - 7.5e-13 48.6 0.3 2e-12 47.2 0.0 1.9 2 0 0 2 2 2 1 GIY-YIG catalytic domain Prok-RING_1 PF14446.6 EKE37506.1 - 0.0027 17.6 6.4 0.022 14.7 3.1 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 HD_3 PF13023.6 EKE37506.1 - 0.028 14.3 0.7 0.054 13.4 0.5 1.5 2 0 0 2 2 2 0 HD domain Cas_Cas6 PF01881.16 EKE37506.1 - 0.085 13.4 0.1 0.16 12.5 0.1 1.4 1 0 0 1 1 1 0 CRISPR associated protein Cas6 OrfB_Zn_ribbon PF07282.11 EKE37506.1 - 0.087 12.8 2.8 0.16 11.9 0.5 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain DiS_P_DiS PF06750.13 EKE37506.1 - 0.089 12.9 5.8 0.7 10.1 0.2 3.0 2 1 1 3 3 3 0 Bacterial Peptidase A24 N-terminal domain FANCL_C PF11793.8 EKE37506.1 - 0.36 11.0 7.6 1.5 9.1 7.6 2.1 1 0 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 EKE37506.1 - 1.2 9.1 9.5 3.2 7.7 9.5 1.8 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 EKE37506.1 - 1.8 8.4 8.7 4.7 7.1 8.7 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Metallophos PF00149.28 EKE37507.1 - 1.3e-30 107.4 1.7 2.2e-30 106.7 1.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EKE37507.1 - 0.0014 18.8 0.0 0.003 17.8 0.0 1.5 1 0 0 1 1 1 1 PPP5 TPR repeat region DUF2273 PF10031.9 EKE37507.1 - 2.6 8.1 7.3 4.7 7.3 1.7 2.5 2 0 0 2 2 2 0 Small integral membrane protein (DUF2273) DUF655 PF04919.12 EKE37508.1 - 0.01 15.8 0.4 0.014 15.4 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF655) Glyoxalase_2 PF12681.7 EKE37508.1 - 0.02 14.8 1.4 0.036 14.0 1.4 1.4 1 0 0 1 1 1 0 Glyoxalase-like domain Pkinase_Tyr PF07714.17 EKE37509.1 - 1.3e-16 60.7 0.0 1.5e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37509.1 - 1.4e-10 41.0 0.0 2e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37510.1 - 4.7e-28 98.2 0.1 7.8e-28 97.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37510.1 - 4.5e-27 95.1 0.1 7.2e-27 94.4 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain VSP PF03302.13 EKE37510.1 - 1.6e-06 27.3 39.4 1.6e-06 27.3 39.4 6.6 1 1 5 6 6 6 4 Giardia variant-specific surface protein TMEM154 PF15102.6 EKE37510.1 - 0.0013 18.7 2.0 0.003 17.5 2.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family Motile_Sperm PF00635.26 EKE37510.1 - 0.015 15.2 0.3 0.042 13.7 0.3 1.7 1 0 0 1 1 1 0 MSP (Major sperm protein) domain EphA2_TM PF14575.6 EKE37510.1 - 0.016 16.1 0.1 0.053 14.4 0.1 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Pkinase_fungal PF17667.1 EKE37510.1 - 0.085 11.6 0.3 0.15 10.8 0.3 1.3 1 0 0 1 1 1 0 Fungal protein kinase Orf78 PF06024.12 EKE37510.1 - 0.13 12.5 0.7 0.35 11.2 0.7 1.7 1 0 0 1 1 1 0 Orf78 (ac78) ODV-E18 PF10717.9 EKE37510.1 - 0.2 11.5 2.8 0.51 10.2 2.8 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF4446 PF14584.6 EKE37510.1 - 0.23 11.4 1.1 0.6 10.1 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF929 PF06053.11 EKE37510.1 - 0.38 10.0 4.6 0.64 9.3 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) Sigma_reg_N PF13800.6 EKE37510.1 - 1.7 9.0 7.0 3.7 7.9 7.0 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF4519 PF15012.6 EKE37510.1 - 2.1 8.5 4.4 5 7.4 4.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) ASFV_J13L PF05568.11 EKE37510.1 - 2.2 8.0 5.3 4.3 7.0 5.3 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF3827 PF12877.7 EKE37510.1 - 2.2 6.5 5.6 3.3 6.0 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Baculo_11_kDa PF06143.11 EKE37510.1 - 4.2 7.0 7.5 8.9 6.0 7.5 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF1223 PF06764.11 EKE37511.1 - 0.45 10.5 5.2 1 9.4 5.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) RhoGAP PF00620.27 EKE37512.1 - 6.6e-20 71.5 0.5 1.9e-19 70.0 0.5 1.8 1 0 0 1 1 1 1 RhoGAP domain RRM_1 PF00076.22 EKE37514.1 - 3.2e-37 126.2 12.2 2e-12 46.8 0.1 5.0 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EKE37514.1 - 2.6e-06 27.5 0.5 6.9e-06 26.2 0.5 1.7 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_3 PF08777.11 EKE37514.1 - 3.8e-05 23.7 8.5 0.12 12.5 0.3 4.3 4 0 0 4 4 4 2 RNA binding motif DUF1987 PF09345.10 EKE37514.1 - 0.00021 20.9 0.6 0.024 14.3 0.5 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1987) Nup35_RRM_2 PF14605.6 EKE37514.1 - 0.0013 18.7 3.7 2.9 8.0 0.5 3.9 3 1 0 3 3 3 2 Nup53/35/40-type RNA recognition motif PH PF00169.29 EKE37514.1 - 0.0083 16.6 0.2 0.032 14.8 0.2 2.0 1 1 0 1 1 1 1 PH domain Thioredoxin_8 PF13905.6 EKE37514.1 - 0.0098 16.2 10.6 0.84 10.0 0.0 4.7 2 1 1 4 4 4 1 Thioredoxin-like RRM_7 PF16367.5 EKE37514.1 - 0.012 15.7 2.0 7.9 6.7 0.1 4.3 3 1 1 4 4 4 0 RNA recognition motif Mer2 PF09074.10 EKE37514.1 - 0.046 13.5 0.3 0.046 13.5 0.3 3.3 3 0 0 3 3 3 0 Mer2 BRAP2 PF07576.12 EKE37514.1 - 0.05 13.8 0.1 0.9 9.8 0.1 2.7 2 0 0 2 2 2 0 BRCA1-associated protein 2 DUF1664 PF07889.12 EKE37514.1 - 0.81 9.7 4.2 0.4 10.7 0.3 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Ribosomal_S19e PF01090.19 EKE37515.1 - 7.2e-54 181.2 0.1 8.2e-54 181.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Pex19 PF04614.12 EKE37518.1 - 4.6e-23 82.3 3.4 5.6e-23 82.0 3.4 1.1 1 0 0 1 1 1 1 Pex19 protein family DUF2999 PF11212.8 EKE37518.1 - 0.08 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2999) DUF4922 PF16269.5 EKE37518.1 - 0.1 12.3 0.2 0.13 12.0 0.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4922) SHOCT PF09851.9 EKE37518.1 - 1.4 8.8 3.7 3.8 7.4 0.9 2.4 2 0 0 2 2 2 0 Short C-terminal domain RabGAP-TBC PF00566.18 EKE37519.1 - 1.7e-28 99.7 5.5 3.9e-28 98.6 5.5 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PDDEXK_10 PF07788.11 EKE37519.1 - 0.024 14.6 0.1 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 PD-(D/E)XK nuclease superfamily DUF853 PF05872.12 EKE37519.1 - 0.19 10.3 0.0 0.27 9.8 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Ribosomal_L28e PF01778.17 EKE37520.1 - 1.7e-30 106.1 0.2 4.6e-30 104.7 0.1 1.8 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EKE37520.1 - 4.4e-08 33.7 16.4 4.4e-08 33.7 16.4 2.1 2 1 0 2 2 2 1 Mak16 protein C-terminal region DUF4771 PF15995.5 EKE37520.1 - 0.27 11.5 8.0 0.13 12.6 3.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4771) Exonuc_VII_L PF02601.15 EKE37520.1 - 0.95 9.0 10.9 1.8 8.1 10.9 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit YlqD PF11068.8 EKE37520.1 - 1.1 9.6 15.0 0.046 14.1 6.0 2.2 1 1 1 2 2 2 0 YlqD protein U1snRNP70_N PF12220.8 EKE37520.1 - 4 8.2 12.8 9 7.0 3.4 2.5 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal CDC45 PF02724.14 EKE37521.1 - 0.09 11.1 18.0 0.1 10.9 18.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Endostatin PF06482.11 EKE37521.1 - 0.3 10.5 9.1 0.39 10.1 9.1 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF2052 PF09747.9 EKE37521.1 - 0.34 11.0 15.8 0.6 10.2 15.8 1.5 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF908 PF06012.12 EKE37521.1 - 0.65 9.3 7.7 3.5 6.9 8.6 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Hid1 PF12722.7 EKE37521.1 - 1.2 7.2 13.7 1.4 6.9 13.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RRN3 PF05327.11 EKE37521.1 - 1.5 7.3 9.9 1.8 7.0 9.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CobT PF06213.12 EKE37521.1 - 4.3 6.7 15.9 5.9 6.2 15.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Neur_chan_memb PF02932.16 EKE37521.1 - 5.7 6.9 11.0 8 6.4 11.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 EKE37521.1 - 6.9 4.9 5.8 8.5 4.6 5.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF913 PF06025.12 EKE37521.1 - 7.3 5.4 12.5 11 4.9 12.5 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ALMT PF11744.8 EKE37521.1 - 8 5.2 18.4 9.8 4.9 18.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Fer4 PF00037.27 EKE37522.1 - 2.2e-15 55.7 16.9 1.4e-09 37.3 5.2 2.1 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EKE37522.1 - 1.1e-10 41.9 12.3 8.1e-10 39.1 12.9 1.8 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 EKE37522.1 - 1.6e-10 40.9 23.8 8.7e-09 35.4 12.9 1.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EKE37522.1 - 2.2e-10 40.0 14.2 1.9e-06 27.6 3.5 2.1 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EKE37522.1 - 2.5e-09 37.6 7.1 0.0002 21.8 0.9 2.0 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EKE37522.1 - 3.4e-09 36.4 14.9 2.2e-06 27.5 3.9 2.1 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 EKE37522.1 - 5.9e-09 35.9 13.9 1.6e-08 34.5 14.1 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_4 PF12800.7 EKE37522.1 - 1.8e-08 34.2 15.3 1.5e-05 25.1 4.1 2.1 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 EKE37522.1 - 1e-07 32.8 11.2 0.00084 20.2 2.3 2.1 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 EKE37522.1 - 3e-07 30.5 14.1 4.2e-07 30.0 14.1 1.3 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EKE37522.1 - 1.6e-06 28.5 12.9 0.0031 17.9 1.9 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 EKE37522.1 - 2.6e-05 24.7 17.4 0.0073 16.8 4.0 2.1 1 1 1 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EKE37522.1 - 0.00013 22.1 12.9 0.0002 21.5 12.9 1.4 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 EKE37522.1 - 0.0002 22.1 19.8 0.00047 20.9 6.3 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 EKE37522.1 - 0.00034 21.3 13.4 0.046 14.5 3.9 2.1 1 1 1 2 2 2 2 4Fe-4S single cluster domain Fer4_22 PF17179.4 EKE37522.1 - 0.0022 18.8 13.7 0.01 16.7 1.9 2.0 1 1 2 3 3 3 3 4Fe-4S dicluster domain DUF678 PF05077.12 EKE37522.1 - 0.41 10.8 7.3 3.5 7.8 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF678) Fer4 PF00037.27 EKE37523.1 - 1.9e-15 55.9 17.1 1.2e-09 37.5 5.3 2.1 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EKE37523.1 - 9.3e-11 42.2 12.5 3e-10 40.5 12.7 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 EKE37523.1 - 1.6e-10 41.0 23.4 8.3e-09 35.5 12.5 1.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EKE37523.1 - 2.2e-10 40.0 14.2 1.9e-06 27.6 3.4 2.1 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 EKE37523.1 - 2.2e-09 37.0 14.8 1.4e-06 28.1 3.9 2.1 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EKE37523.1 - 2.4e-09 37.6 6.9 0.00022 21.7 0.8 2.0 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EKE37523.1 - 7.4e-09 35.6 13.9 2.3e-08 34.0 14.2 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 EKE37523.1 - 1.9e-08 34.3 12.9 2.5e-08 33.9 12.9 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_4 PF12800.7 EKE37523.1 - 3e-08 33.5 15.3 2.5e-05 24.4 4.1 2.1 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 EKE37523.1 - 7.7e-08 33.2 11.3 0.00062 20.6 2.3 2.1 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_8 PF13183.6 EKE37523.1 - 9.6e-07 29.2 12.5 0.0015 18.9 2.0 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 EKE37523.1 - 1.8e-05 25.2 16.7 0.0073 16.8 4.0 2.1 1 1 1 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EKE37523.1 - 9e-05 22.6 13.8 0.0008 19.6 3.2 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 EKE37523.1 - 0.00014 22.5 20.1 0.00034 21.3 6.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 EKE37523.1 - 0.00042 21.0 13.2 0.056 14.2 3.7 2.1 1 1 1 2 2 2 2 4Fe-4S single cluster domain Fer4_22 PF17179.4 EKE37523.1 - 0.0026 18.5 13.9 0.011 16.5 2.0 2.0 1 1 2 3 3 3 3 4Fe-4S dicluster domain DUF678 PF05077.12 EKE37523.1 - 0.43 10.8 7.3 3.6 7.8 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF678) SieB PF14163.6 EKE37524.1 - 0.028 13.9 4.7 0.032 13.7 2.8 2.2 2 1 0 2 2 2 0 Super-infection exclusion protein B Neur_chan_memb PF02932.16 EKE37524.1 - 0.49 10.4 5.1 0.61 10.1 5.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NAPRTase_C PF17956.1 EKE37524.1 - 2.1 8.8 10.6 0.64 10.5 1.1 3.1 1 1 2 3 3 3 0 Nicotinate phosphoribosyltransferase C-terminal domain Cyclin_N PF00134.23 EKE37525.1 - 3.3e-12 46.3 2.0 5.6e-12 45.5 2.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ndr PF03096.14 EKE37526.1 - 0.00016 20.5 0.3 0.00032 19.5 0.3 1.5 1 0 0 1 1 1 1 Ndr family Abhydrolase_3 PF07859.13 EKE37526.1 - 0.0023 17.8 0.0 0.0043 16.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold YchF-GTPase_C PF06071.13 EKE37527.1 - 9e-38 128.3 0.4 9e-38 128.3 0.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EKE37527.1 - 2e-22 79.4 0.0 6.9e-22 77.7 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKE37527.1 - 1.4e-08 34.4 0.0 4e-08 32.9 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 EKE37527.1 - 0.01 14.8 0.0 0.017 14.1 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Arteri_GP4 PF02497.15 EKE37527.1 - 0.044 13.9 0.0 0.078 13.1 0.0 1.3 1 0 0 1 1 1 0 Arterivirus glycoprotein Roc PF08477.13 EKE37527.1 - 0.055 13.7 0.0 0.18 12.0 0.0 1.9 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EKE37527.1 - 0.064 12.8 0.2 1.4 8.5 0.0 2.5 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_14 PF13173.6 EKE37527.1 - 0.069 13.2 0.1 0.93 9.5 0.0 2.5 3 0 0 3 3 3 0 AAA domain Arf PF00025.21 EKE37527.1 - 0.084 12.3 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 ADP-ribosylation factor family RNA_helicase PF00910.22 EKE37527.1 - 0.11 12.9 0.0 31 5.0 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Stealth_CR1 PF17101.5 EKE37527.1 - 0.17 11.6 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 Stealth protein CR1, conserved region 1 IPK PF03770.16 EKE37528.1 - 3 7.6 9.6 5 6.9 9.6 1.3 1 1 0 1 1 1 0 Inositol polyphosphate kinase EVC2_like PF12297.8 EKE37529.1 - 0.013 14.2 0.0 0.02 13.6 0.0 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein DUF2808 PF10989.8 EKE37529.1 - 0.056 13.4 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) Peptidase_M60 PF13402.6 EKE37530.1 - 9.1e-24 84.4 0.4 1.8e-23 83.5 0.4 1.4 1 0 0 1 1 1 1 Peptidase M60, enhancin and enhancin-like PqiA PF04403.13 EKE37531.1 - 5.4e-12 45.8 29.6 4.6e-07 29.8 9.0 3.2 3 0 0 3 3 3 2 Paraquat-inducible protein A Peptidase_S49_N PF08496.10 EKE37531.1 - 0.01 15.9 0.1 0.038 14.1 0.1 1.9 1 0 0 1 1 1 1 Peptidase family S49 N-terminal DUF1394 PF07159.12 EKE37532.1 - 3.2e-103 345.2 0.3 3.6e-103 345.0 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) dNK PF01712.19 EKE37533.1 - 1.3e-11 44.8 1.8 2.5e-07 30.8 0.2 2.3 1 1 0 2 2 2 2 Deoxynucleoside kinase AAA_18 PF13238.6 EKE37533.1 - 0.00017 22.2 0.3 0.01 16.4 0.3 2.4 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 EKE37533.1 - 0.0012 18.4 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 EKE37533.1 - 0.0035 16.6 0.0 0.014 14.7 0.0 1.9 3 0 0 3 3 3 1 Zeta toxin TrwB_AAD_bind PF10412.9 EKE37533.1 - 0.0044 16.0 0.1 0.0087 15.0 0.0 1.4 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 EKE37533.1 - 0.011 15.8 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 EKE37533.1 - 0.017 14.2 0.0 0.037 13.1 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 EKE37533.1 - 0.018 15.6 0.0 0.03 14.8 0.0 1.4 1 1 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 EKE37533.1 - 0.023 14.9 0.1 1.6 8.9 0.0 2.3 1 1 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 EKE37533.1 - 0.025 14.3 0.7 3.9 7.1 0.1 2.5 2 1 0 2 2 2 0 Thymidylate kinase NTPase_1 PF03266.15 EKE37533.1 - 0.027 14.4 0.1 0.053 13.4 0.1 1.5 1 0 0 1 1 1 0 NTPase RsgA_GTPase PF03193.16 EKE37533.1 - 0.042 13.8 0.0 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EKE37533.1 - 0.051 14.0 0.0 0.084 13.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 EKE37533.1 - 0.094 13.2 7.5 0.96 9.9 7.5 2.1 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EKE37533.1 - 0.1 13.1 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EKE37533.1 - 0.13 12.3 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Gemini_AL1 PF00799.20 EKE37537.1 - 0.018 15.4 1.2 0.052 13.9 0.0 2.4 3 0 0 3 3 3 0 Geminivirus Rep catalytic domain GramPos_pilinD3 PF16570.5 EKE37537.1 - 0.053 14.3 0.2 0.13 13.0 0.2 1.6 1 0 0 1 1 1 0 Gram-positive pilin backbone subunit 3, Cna-B-like domain Mucin PF01456.17 EKE37538.1 - 0.0061 16.6 15.4 0.0061 16.6 15.4 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF5128 PF17170.4 EKE37538.1 - 0.012 14.8 1.1 0.015 14.5 0.6 1.3 1 1 0 1 1 1 0 6-bladed beta-propeller Zip PF02535.22 EKE37538.1 - 0.048 12.9 0.5 0.068 12.4 0.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Kei1 PF08552.11 EKE37538.1 - 0.11 12.4 0.5 0.11 12.3 0.5 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Presenilin PF01080.17 EKE37538.1 - 0.13 11.0 1.8 0.14 10.9 1.8 1.2 1 0 0 1 1 1 0 Presenilin Med13_C PF06333.12 EKE37538.1 - 0.17 11.1 4.6 0.18 11.0 4.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain DUF5523 PF17661.1 EKE37538.1 - 0.17 11.5 3.5 0.21 11.2 3.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) FSA_C PF10479.9 EKE37538.1 - 0.22 9.6 9.4 0.22 9.6 9.4 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SSP160 PF06933.11 EKE37538.1 - 0.34 9.1 12.9 0.36 9.0 12.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 EKE37538.1 - 0.51 8.3 9.4 0.55 8.2 9.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein HSP70 PF00012.20 EKE37539.1 - 3.4e-15 55.3 10.3 3.8e-15 55.1 10.3 1.0 1 0 0 1 1 1 1 Hsp70 protein Pex19 PF04614.12 EKE37539.1 - 0.0054 16.5 4.4 0.0085 15.9 4.4 1.3 1 1 0 1 1 1 1 Pex19 protein family FeoB_Cyto PF17910.1 EKE37539.1 - 0.013 16.1 3.1 0.026 15.1 3.1 1.6 1 0 0 1 1 1 0 FeoB cytosolic helical domain Hat1_N PF10394.9 EKE37539.1 - 0.026 14.8 1.1 0.026 14.8 1.1 1.5 1 1 0 1 1 1 0 Histone acetyl transferase HAT1 N-terminus WD-3 PF09765.9 EKE37539.1 - 0.031 13.6 1.6 0.036 13.4 1.6 1.0 1 0 0 1 1 1 0 WD-repeat region DctP PF03480.13 EKE37539.1 - 0.032 13.6 3.1 0.034 13.5 2.5 1.3 1 1 0 1 1 1 0 Bacterial extracellular solute-binding protein, family 7 RAMPs PF03787.15 EKE37539.1 - 0.035 14.1 0.2 0.042 13.9 0.2 1.1 1 0 0 1 1 1 0 RAMP superfamily KMP11 PF03037.16 EKE37539.1 - 0.067 14.0 0.7 0.067 14.0 0.7 2.0 1 1 1 2 2 2 0 Kinetoplastid membrane protein 11 DUF1366 PF07104.11 EKE37539.1 - 0.36 10.5 8.3 0.18 11.5 4.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1366) DUF2408 PF10303.9 EKE37539.1 - 0.95 10.0 6.6 3.3 8.3 6.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) zf-ZPR1 PF03367.13 EKE37539.1 - 2.2 8.1 6.2 9.8 6.0 0.3 2.1 1 1 1 2 2 2 0 ZPR1 zinc-finger domain DUF4889 PF16230.5 EKE37539.1 - 6.8 7.0 9.3 15 5.9 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4889) Tho2 PF11262.8 EKE37540.1 - 2.6e-13 49.9 9.2 2.6e-13 49.9 9.2 1.8 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EKE37540.1 - 0.032 14.3 0.0 0.14 12.2 0.0 2.2 1 0 0 1 1 1 0 Transcription- and export-related complex subunit RhoGAP PF00620.27 EKE37541.1 - 1e-33 116.3 0.0 1.7e-33 115.6 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Syntaxin PF00804.25 EKE37542.1 - 4.1e-07 29.9 8.0 2.6e-06 27.2 0.6 2.5 1 1 0 2 2 2 2 Syntaxin DUF2209 PF09974.9 EKE37542.1 - 0.021 15.2 1.6 0.038 14.3 0.4 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2209) RNA_pol_Rpb5_C PF01191.19 EKE37542.1 - 0.024 14.5 1.7 0.024 14.5 1.7 2.3 1 1 1 2 2 2 0 RNA polymerase Rpb5, C-terminal domain NTP_transferase PF00483.23 EKE37544.1 - 2.1e-45 155.2 0.0 3.3e-45 154.6 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EKE37544.1 - 2.3e-05 24.8 0.0 3.4e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain MannoseP_isomer PF01050.18 EKE37544.1 - 0.00036 20.5 0.0 0.08 12.8 0.0 2.5 2 0 0 2 2 2 2 Mannose-6-phosphate isomerase DUF2812 PF11193.8 EKE37544.1 - 0.11 12.7 0.0 0.35 11.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2812) Pkinase PF00069.25 EKE37545.1 - 2.3e-63 214.0 0.6 5.4e-63 212.8 0.2 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37545.1 - 6.4e-47 160.0 0.0 1.1e-46 159.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37545.1 - 7e-05 21.8 0.0 7e-05 21.8 0.0 2.0 2 1 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EKE37545.1 - 0.0013 18.1 0.0 0.0048 16.2 0.0 2.0 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKE37545.1 - 0.017 14.5 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ORF6C PF10552.9 EKE37545.1 - 9.4 6.4 11.5 2.5 8.2 3.6 3.6 3 1 0 3 3 3 0 ORF6C domain Helicase_C PF00271.31 EKE37546.1 - 6.9e-26 90.8 0.3 2.2e-25 89.1 0.3 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EKE37546.1 - 8.9e-26 90.7 1.2 1.1e-24 87.2 0.1 2.5 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EKE37546.1 - 1.2e-07 31.9 0.6 1.2e-05 25.3 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Zea_mays_MuDR PF05928.11 EKE37546.1 - 0.051 13.2 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 Zea mays MURB-like protein (MuDR) DUF3875 PF12991.7 EKE37546.1 - 0.1 12.6 0.8 2.3 8.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function, B. Theta Gene description (DUF3875) Aa_trans PF01490.18 EKE37547.1 - 1.2e-17 63.7 38.2 2.6e-17 62.7 38.2 1.6 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EKE37547.1 - 0.017 14.2 39.2 0.0071 15.4 34.2 2.5 1 1 1 2 2 2 0 Tryptophan/tyrosine permease family KASH PF10541.9 EKE37547.1 - 0.23 11.8 0.0 0.23 11.8 0.0 3.0 3 0 0 3 3 3 0 Nuclear envelope localisation domain DUF2205 PF10224.9 EKE37548.1 - 0.00028 20.8 3.1 0.00067 19.6 3.1 1.6 1 0 0 1 1 1 1 Short coiled-coil protein YabA PF06156.13 EKE37548.1 - 0.0025 18.4 3.0 0.0025 18.4 3.0 1.8 2 0 0 2 2 2 1 Initiation control protein YabA bZIP_1 PF00170.21 EKE37548.1 - 0.019 15.1 2.5 0.047 13.8 2.5 1.7 1 0 0 1 1 1 0 bZIP transcription factor DUF4988 PF16378.5 EKE37548.1 - 0.036 13.7 3.4 0.061 13.0 3.4 1.4 1 0 0 1 1 1 0 Domain of unknown function TBCA PF02970.16 EKE37548.1 - 0.057 13.7 4.0 1.5 9.2 1.2 2.6 2 0 0 2 2 2 0 Tubulin binding cofactor A Pyr_redox PF00070.27 EKE37548.1 - 0.14 12.7 0.3 0.4 11.3 0.3 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TSC22 PF01166.18 EKE37548.1 - 0.42 11.0 6.6 0.38 11.1 4.0 2.2 2 0 0 2 2 2 0 TSC-22/dip/bun family ZapB PF06005.12 EKE37548.1 - 1.1 9.7 9.3 0.64 10.5 4.6 2.4 2 0 0 2 2 2 0 Cell division protein ZapB Chibby PF14645.6 EKE37548.1 - 1.4 9.3 6.4 1.5 9.2 5.1 1.7 1 1 1 2 2 2 0 Chibby family HSP70 PF00012.20 EKE37549.1 - 2.2e-07 29.5 0.4 2.2e-07 29.5 0.4 1.0 1 0 0 1 1 1 1 Hsp70 protein PolyA_pol PF01743.20 EKE37550.1 - 6.1e-32 110.7 0.6 1.3e-31 109.6 0.6 1.6 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EKE37550.1 - 0.00023 20.8 0.0 0.00094 18.9 0.0 2.1 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 EKE37550.1 - 0.0041 17.1 4.4 0.0097 15.9 0.2 2.8 3 0 0 3 3 3 1 tRNA nucleotidyltransferase domain 2 putative SH3_1 PF00018.28 EKE37551.1 - 2.5e-14 52.6 0.1 8.6e-14 50.9 0.1 2.0 2 0 0 2 2 2 1 SH3 domain Cofilin_ADF PF00241.20 EKE37551.1 - 1.2e-12 47.7 0.2 2.6e-12 46.6 0.2 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_9 PF14604.6 EKE37551.1 - 1.9e-11 43.6 0.1 4.1e-11 42.6 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EKE37551.1 - 4.9e-09 35.7 0.1 2.8e-08 33.3 0.0 2.3 2 1 0 2 2 2 1 Variant SH3 domain DUF5123 PF17161.4 EKE37551.1 - 2 9.5 6.7 2.2 9.4 3.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5123) RNB PF00773.19 EKE37552.1 - 1.5e-05 24.5 0.3 1.5e-05 24.5 0.3 1.9 2 1 1 3 3 3 1 RNB domain Pkinase PF00069.25 EKE37553.1 - 7.3e-72 241.9 0.0 8.5e-72 241.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37553.1 - 2.3e-35 122.1 0.1 7.2e-35 120.5 0.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE37553.1 - 3e-07 30.0 0.2 4.4e-06 26.2 0.0 2.3 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EKE37553.1 - 0.0003 19.7 0.1 0.0018 17.2 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EKE37553.1 - 0.0006 18.9 2.3 0.0015 17.5 2.3 1.6 1 1 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 EKE37553.1 - 0.0045 16.6 1.1 0.064 12.9 0.1 2.2 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EKE37553.1 - 0.0074 16.2 0.1 0.073 13.0 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EKE37553.1 - 0.075 12.4 0.9 0.15 11.4 0.9 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-G-binding_N PF07299.11 EKE37553.1 - 0.65 10.6 4.3 19 5.9 0.3 3.1 2 1 0 3 3 3 0 Elongation factor G-binding protein, N-terminal PH_6 PF15406.6 EKE37556.1 - 0.035 14.4 0.0 0.14 12.4 0.0 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain HAUS2 PF15003.6 EKE37556.1 - 1.6 8.4 7.8 0.14 11.9 1.8 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 2 PTPRCAP PF15713.5 EKE37556.1 - 8.5 6.6 9.0 17 5.7 9.0 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Sec3_C PF09763.9 EKE37557.1 - 6.5e-39 133.9 32.1 3.7e-20 71.9 21.2 2.3 1 1 1 2 2 2 2 Exocyst complex component Sec3 Carot_N PF09150.10 EKE37557.1 - 0.046 13.6 0.5 0.92 9.4 0.3 2.7 2 0 0 2 2 2 0 Orange carotenoid protein, N-terminal Choline_kinase PF01633.20 EKE37558.1 - 2.4e-52 177.6 0.7 3.7e-52 177.0 0.7 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKE37558.1 - 4.9e-12 46.3 0.0 7.5e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EKE37558.1 - 4e-05 23.1 1.0 5.9e-05 22.5 0.6 1.5 2 0 0 2 2 2 1 Ecdysteroid kinase DUF1679 PF07914.11 EKE37558.1 - 0.021 13.7 0.2 0.028 13.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Kdo PF06293.14 EKE37558.1 - 0.038 13.3 0.1 0.073 12.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LSM PF01423.22 EKE37559.1 - 7.2e-05 22.4 0.0 8.4e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 LSM domain BPL_C PF02237.17 EKE37559.1 - 0.00068 19.5 0.1 0.00086 19.2 0.1 1.3 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain DASH_Dam1 PF08653.10 EKE37560.1 - 3.1 7.7 7.3 16 5.4 1.0 3.4 2 1 1 3 3 3 0 DASH complex subunit Dam1 Mod_r PF07200.13 EKE37560.1 - 6.5 6.8 28.6 0.048 13.8 11.3 3.4 2 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Glyco_hydro_77 PF02446.17 EKE37561.1 - 1.2e-137 459.6 0.1 1.6e-137 459.2 0.1 1.1 1 0 0 1 1 1 1 4-alpha-glucanotransferase CBM_20 PF00686.19 EKE37561.1 - 1.6e-16 59.9 0.1 1.6e-12 47.1 0.0 2.7 2 0 0 2 2 2 2 Starch binding domain Pkinase_Tyr PF07714.17 EKE37562.1 - 7.2e-49 166.4 0.0 1.1e-48 165.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37562.1 - 2.7e-38 131.8 0.0 4.6e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SEP PF08059.13 EKE37563.1 - 1.3e-18 67.3 0.2 2.1e-17 63.4 0.0 2.6 3 0 0 3 3 3 1 SEP domain UBX PF00789.20 EKE37563.1 - 2.9e-06 27.4 0.1 7.1e-06 26.1 0.1 1.6 1 0 0 1 1 1 1 UBX domain ubiquitin PF00240.23 EKE37563.1 - 0.0072 16.1 0.1 0.02 14.6 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin family LRR_5 PF13306.6 EKE37564.1 - 3.1e-59 198.5 30.2 1.2e-19 70.6 3.4 4.1 3 1 0 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE37564.1 - 5.2e-11 42.1 0.0 0.018 14.8 0.0 5.6 3 3 3 6 6 6 5 Leucine rich repeat Mob1_phocein PF03637.17 EKE37565.1 - 4.5e-57 192.8 0.2 5.4e-57 192.5 0.2 1.1 1 0 0 1 1 1 1 Mob1/phocein family DUF3717 PF12512.8 EKE37565.1 - 0.082 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3717) DUF4131 PF13567.6 EKE37566.1 - 0.099 12.3 0.4 0.23 11.1 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) RasGEF PF00617.19 EKE37567.1 - 1.1e-45 156.1 0.3 6.8e-45 153.4 0.0 2.1 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EKE37567.1 - 4.1e-13 49.5 1.8 5.5e-13 49.1 0.2 2.1 2 1 1 3 3 3 1 RasGEF N-terminal motif DUF4404 PF14357.6 EKE37567.1 - 0.13 12.9 0.0 0.13 12.9 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) SAS-6_N PF16531.5 EKE37567.1 - 0.67 10.6 3.7 1.1 9.9 1.9 2.3 3 0 0 3 3 3 0 Centriolar protein SAS N-terminal SET PF00856.28 EKE37568.1 - 1.8e-07 31.7 0.0 1.8e-07 31.7 0.0 3.3 3 1 0 3 3 3 1 SET domain Rubis-subs-bind PF09273.11 EKE37568.1 - 0.00051 20.7 0.2 0.0012 19.6 0.2 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding ImmE5 PF11480.8 EKE37568.1 - 0.66 10.5 3.7 0.68 10.5 0.1 2.8 3 0 0 3 3 3 0 Colicin-E5 Imm protein WD40 PF00400.32 EKE37569.1 - 5.5e-06 27.0 2.7 0.0016 19.2 0.0 4.1 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE37569.1 - 1.2e-05 25.5 0.5 0.33 11.3 0.1 4.1 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EKE37569.1 - 2.4e-05 23.5 0.2 4.8e-05 22.5 0.2 1.5 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Glu_cyclase_2 PF05096.12 EKE37569.1 - 0.061 12.8 0.1 5.1 6.5 0.1 2.2 1 1 1 2 2 2 0 Glutamine cyclotransferase AsnA PF03590.15 EKE37570.1 - 1.1e-96 323.0 0.3 1.3e-96 322.7 0.3 1.1 1 0 0 1 1 1 1 Aspartate-ammonia ligase tRNA-synt_2 PF00152.20 EKE37570.1 - 0.00037 19.7 0.0 0.00066 18.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) LRR_5 PF13306.6 EKE37571.1 - 1.3e-57 193.3 30.9 3.9e-31 107.7 11.8 2.7 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE37571.1 - 3.6e-10 39.5 0.1 0.038 13.7 0.0 4.5 3 2 2 5 5 5 4 Leucine rich repeat FNIP PF05725.12 EKE37571.1 - 0.79 9.9 0.1 0.79 9.9 0.1 5.2 5 1 0 5 5 5 0 FNIP Repeat MICSWaP PF17018.5 EKE37573.1 - 0.058 12.9 0.4 0.064 12.8 0.4 1.1 1 0 0 1 1 1 0 Spore wall protein FERM_F2 PF18377.1 EKE37573.1 - 0.072 13.0 0.1 0.075 13.0 0.1 1.1 1 0 0 1 1 1 0 FERM F2 acyl-CoA binding protein-like domain Pkinase PF00069.25 EKE37574.1 - 4e-62 210.0 0.0 6.2e-62 209.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37574.1 - 6.6e-45 153.4 0.0 1.2e-44 152.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37574.1 - 0.00057 18.8 0.0 0.00087 18.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKE37574.1 - 0.0015 17.9 0.0 0.0035 16.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EKE37574.1 - 0.002 18.1 0.0 0.0036 17.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family ABC1 PF03109.16 EKE37574.1 - 0.0031 17.7 0.0 0.0066 16.6 0.0 1.5 1 0 0 1 1 1 1 ABC1 family Haspin_kinase PF12330.8 EKE37574.1 - 0.01 14.8 0.0 0.02 13.8 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EKE37574.1 - 0.072 12.7 0.1 0.34 10.5 0.0 2.0 2 0 0 2 2 2 0 RIO1 family PNK3P PF08645.11 EKE37575.1 - 5.1e-56 188.8 0.8 9.5e-56 188.0 0.8 1.5 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EKE37575.1 - 6.5e-12 45.8 0.0 7.9e-05 22.8 0.0 2.4 1 1 1 2 2 2 2 AAA domain NIF PF03031.18 EKE37575.1 - 0.059 13.1 0.4 0.44 10.3 0.1 2.3 2 1 0 2 2 2 0 NLI interacting factor-like phosphatase Hydrolase PF00702.26 EKE37575.1 - 0.19 12.0 0.4 5.2 7.3 0.6 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase RhoGAP PF00620.27 EKE37576.1 - 5.1e-12 45.9 3.4 7.2e-12 45.4 2.0 2.0 1 1 1 2 2 2 1 RhoGAP domain APS_kinase PF01583.20 EKE37576.1 - 0.093 12.6 0.0 1.9 8.3 0.0 2.6 3 0 0 3 3 3 0 Adenylylsulphate kinase PQ-loop PF04193.14 EKE37577.1 - 2.6e-32 110.4 17.8 4.6e-17 61.5 1.9 2.8 3 0 0 3 3 3 2 PQ loop repeat MtN3_slv PF03083.16 EKE37577.1 - 0.0048 16.9 0.7 0.0048 16.9 0.7 3.4 3 2 1 4 4 4 1 Sugar efflux transporter for intercellular exchange ER_lumen_recept PF00810.18 EKE37577.1 - 0.58 11.0 15.0 4.2 8.2 0.1 3.7 1 1 2 3 3 3 0 ER lumen protein retaining receptor NDUF_B6 PF09782.9 EKE37577.1 - 3.6 7.7 6.2 1.3 9.1 1.1 2.3 2 1 1 3 3 3 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Tyr-DNA_phospho PF06087.12 EKE37579.1 - 5.2e-61 206.8 0.8 6.6e-61 206.5 0.8 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EKE37579.1 - 0.055 13.4 0.2 0.35 10.7 0.0 2.2 2 1 0 2 2 2 0 PLD-like domain C2 PF00168.30 EKE37580.1 - 1e-11 45.0 0.2 1.8e-08 34.6 0.0 2.6 2 0 0 2 2 2 2 C2 domain DHHC PF01529.20 EKE37581.1 - 3.3e-31 108.2 16.5 3.3e-31 108.2 16.5 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase Thioredoxin_7 PF13899.6 EKE37582.1 - 3.6e-17 62.3 0.0 4.9e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredox_DsbH PF03190.15 EKE37582.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Spt4 PF06093.13 EKE37583.1 - 1.5e-15 57.0 1.0 2e-15 56.6 1.0 1.2 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger DNA_ligase_A_N PF04675.14 EKE37583.1 - 0.17 12.2 0.0 0.22 11.8 0.0 1.1 1 0 0 1 1 1 0 DNA ligase N terminus AMP-binding PF00501.28 EKE37584.1 - 1.4e-73 247.9 0.0 1.7e-73 247.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme PUF PF00806.19 EKE37585.1 - 2.6e-53 174.8 17.6 2.5e-09 36.3 0.1 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat HATPase_c_5 PF14501.6 EKE37585.1 - 0.2 11.6 5.5 0.16 11.9 3.3 2.0 2 0 0 2 2 2 0 GHKL domain DUF4556 PF15094.6 EKE37587.1 - 0.0066 15.7 0.0 0.014 14.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4556) Clat_adaptor_s PF01217.20 EKE37587.1 - 3.9 7.4 10.8 0.057 13.4 2.6 2.2 2 1 0 2 2 2 0 Clathrin adaptor complex small chain WYL_2 PF10902.8 EKE37589.1 - 0.13 12.6 0.3 1.1 9.6 0.0 2.6 3 0 0 3 3 3 0 WYL_2, Sm-like SH3 beta-barrel fold Sybindin PF04099.12 EKE37590.1 - 1.4e-33 115.9 0.5 1.5e-33 115.7 0.5 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EKE37590.1 - 1e-06 28.9 0.2 2.7e-06 27.5 0.1 1.5 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region A_thal_3526 PF09713.10 EKE37592.1 - 1.1e-15 57.6 1.0 1.8e-15 56.9 1.0 1.4 1 0 0 1 1 1 1 Plant protein 1589 of unknown function (A_thal_3526) Metallophos PF00149.28 EKE37593.1 - 1.8e-27 97.2 0.7 4.7e-27 95.8 0.1 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase tRNA-synt_2 PF00152.20 EKE37594.1 - 2e-94 316.2 0.0 2.4e-94 316.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EKE37594.1 - 1.4e-11 44.2 0.0 2.2e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EKE37594.1 - 0.053 13.0 0.0 0.77 9.2 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.6 EKE37594.1 - 0.1 12.8 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DUF3188 PF11384.8 EKE37597.1 - 1.1 9.0 5.3 0.83 9.4 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3188) Peptidase_M24 PF00557.24 EKE37598.1 - 3e-39 134.9 0.0 3.7e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Ribosomal_S21e PF01249.18 EKE37599.1 - 2.9e-27 94.6 0.0 3.6e-27 94.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e AIG1 PF04548.16 EKE37601.1 - 0.0067 15.8 1.6 0.0098 15.2 0.2 1.8 1 1 0 2 2 2 1 AIG1 family Sigma54_activat PF00158.26 EKE37601.1 - 0.014 15.1 0.2 0.051 13.3 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain MMR_HSR1 PF01926.23 EKE37601.1 - 0.018 15.1 1.1 0.028 14.5 1.1 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 EKE37601.1 - 0.031 14.5 0.0 0.041 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKE37601.1 - 0.076 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EKE37601.1 - 0.14 12.7 2.6 0.29 11.7 2.6 1.7 1 1 0 1 1 1 0 ABC transporter DNA_ligase_OB_2 PF14743.6 EKE37601.1 - 2.4 8.2 6.0 5.3 7.2 0.1 2.6 3 0 0 3 3 3 0 DNA ligase OB-like domain Phage_holin_3_6 PF07332.11 EKE37601.1 - 7.5 6.6 12.0 11 6.1 12.0 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DNA_topoisoIV PF00521.20 EKE37602.1 - 1.1e-124 416.7 0.2 1.1e-124 416.7 0.2 2.1 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EKE37602.1 - 1.9e-48 164.0 2.0 1.9e-48 164.0 2.0 3.7 3 0 0 3 3 3 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EKE37602.1 - 3.1e-24 85.4 0.9 6.3e-24 84.4 0.2 1.9 2 0 0 2 2 2 1 DNA gyrase B HATPase_c PF02518.26 EKE37602.1 - 4.1e-12 46.6 1.2 6.7e-12 45.9 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EKE37602.1 - 6.1e-06 26.4 0.1 3.9e-05 23.8 0.0 2.5 2 0 0 2 2 2 1 Toprim domain DHR-2 PF06920.13 EKE37603.1 - 2.1e-63 214.8 23.1 2.1e-63 214.8 23.1 3.8 4 0 0 4 4 4 1 Dock homology region 2 DOCK-C2 PF14429.6 EKE37603.1 - 5.3e-28 98.2 4.7 1.6e-27 96.6 4.7 1.9 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3658 PF12395.8 EKE37604.1 - 0.02 14.8 1.3 0.033 14.1 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function UPF0160 PF03690.13 EKE37605.1 - 7e-51 173.7 0.0 1.2e-50 173.0 0.0 1.3 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0160) Apolipoprotein PF01442.18 EKE37606.1 - 0.0002 21.3 2.6 0.0022 17.9 2.7 2.1 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF948 PF06103.11 EKE37606.1 - 0.00062 20.0 19.7 0.5 10.7 1.1 3.9 1 1 1 3 3 3 2 Bacterial protein of unknown function (DUF948) YkyA PF10368.9 EKE37606.1 - 0.0017 18.1 15.0 0.0038 16.9 9.1 2.3 1 1 1 2 2 2 1 Putative cell-wall binding lipoprotein V-SNARE_C PF12352.8 EKE37606.1 - 0.0021 18.3 0.3 0.32 11.3 0.0 3.7 3 1 1 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus MCPsignal PF00015.21 EKE37606.1 - 0.0057 16.5 12.6 0.055 13.3 0.5 3.1 1 1 2 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain ApoLp-III PF07464.11 EKE37606.1 - 0.0063 16.6 27.4 0.067 13.3 13.6 3.1 1 1 2 3 3 3 2 Apolipophorin-III precursor (apoLp-III) Laminin_II PF06009.12 EKE37606.1 - 0.0084 16.1 21.6 0.031 14.3 4.4 4.0 1 1 2 4 4 4 2 Laminin Domain II Senescence PF06911.12 EKE37606.1 - 0.0096 16.2 11.0 0.0096 16.2 11.0 3.2 1 1 2 3 3 3 1 Senescence-associated protein YtxH PF12732.7 EKE37606.1 - 0.011 16.3 34.9 1.8e+04 -14.1 34.9 5.1 1 1 0 1 1 0 0 YtxH-like protein Vps53_N PF04100.12 EKE37606.1 - 0.016 14.2 0.6 0.016 14.2 0.6 2.2 1 1 1 2 2 2 0 Vps53-like, N-terminal OmpH PF03938.14 EKE37606.1 - 0.018 15.4 23.0 0.092 13.1 11.9 2.7 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) DUF883 PF05957.13 EKE37606.1 - 0.021 15.4 4.6 0.74 10.5 1.1 3.4 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF883) Phage_Mu_Gam PF07352.12 EKE37606.1 - 0.023 14.6 13.7 0.079 12.9 0.6 2.6 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein Exonuc_VII_L PF02601.15 EKE37606.1 - 0.029 14.0 7.4 0.23 11.0 7.3 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit Syntaxin_2 PF14523.6 EKE37606.1 - 0.034 14.5 19.9 0.71 10.3 0.5 3.5 2 1 1 3 3 3 0 Syntaxin-like protein Baculo_PEP_C PF04513.12 EKE37606.1 - 0.036 14.1 6.5 2.3 8.2 1.9 2.4 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ISG65-75 PF11727.8 EKE37606.1 - 0.043 13.1 22.3 0.27 10.4 12.5 2.8 1 1 2 3 3 3 0 Invariant surface glycoprotein Streptin-Immun PF11083.8 EKE37606.1 - 0.046 14.1 7.1 3.8 8.0 0.3 3.5 2 1 1 3 3 3 0 Lantibiotic streptin immunity protein FliJ PF02050.16 EKE37606.1 - 0.051 13.8 4.8 1.8 8.8 0.1 3.1 2 1 1 3 3 3 0 Flagellar FliJ protein CLZ PF16526.5 EKE37606.1 - 0.068 13.5 4.2 1.2 9.5 1.7 3.3 2 2 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels IFT57 PF10498.9 EKE37606.1 - 0.091 11.7 11.8 0.38 9.7 4.6 2.7 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 Lebercilin PF15619.6 EKE37606.1 - 0.1 12.3 12.1 0.02 14.6 3.4 2.4 3 0 0 3 3 2 0 Ciliary protein causing Leber congenital amaurosis disease Muted PF14942.6 EKE37606.1 - 0.14 12.5 11.9 0.91 9.9 3.2 2.5 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein DUF4456 PF14644.6 EKE37606.1 - 0.14 11.8 4.1 0.24 11.1 1.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4456) DSX_dimer PF08828.10 EKE37606.1 - 0.21 11.3 1.1 2.6 7.8 0.1 2.5 2 0 0 2 2 2 0 Doublesex dimerisation domain V-ATPase_G_2 PF16999.5 EKE37606.1 - 0.24 11.8 3.5 2 8.9 2.9 2.3 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit DegS PF05384.11 EKE37606.1 - 0.29 10.6 6.6 0.97 8.9 2.2 2.4 2 0 0 2 2 2 0 Sensor protein DegS Dynamin_M PF01031.20 EKE37606.1 - 0.3 10.3 10.4 0.45 9.7 2.0 2.2 1 1 1 2 2 2 0 Dynamin central region Prominin PF05478.11 EKE37606.1 - 0.3 9.0 13.1 1.8 6.4 13.1 1.9 1 1 0 1 1 1 0 Prominin DUF1993 PF09351.10 EKE37606.1 - 0.33 11.1 3.9 0.72 10.0 3.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1993) T7SS_ESX_EspC PF10824.8 EKE37606.1 - 0.42 11.1 4.5 1.2 9.6 2.2 2.7 1 1 0 2 2 2 0 Excreted virulence factor EspC, type VII ESX diderm WXG100 PF06013.12 EKE37606.1 - 0.5 10.6 10.3 5.7 7.2 1.9 4.3 1 1 4 5 5 5 0 Proteins of 100 residues with WXG DUF3300 PF11737.8 EKE37606.1 - 0.55 9.7 6.0 0.63 9.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3300) Seryl_tRNA_N PF02403.22 EKE37606.1 - 0.74 10.1 16.8 0.67 10.2 5.3 3.0 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ALIX_LYPXL_bnd PF13949.6 EKE37606.1 - 0.78 9.0 13.5 2.7 7.2 3.1 2.4 1 1 1 2 2 2 0 ALIX V-shaped domain binding to HIV KxDL PF10241.9 EKE37606.1 - 0.93 9.8 15.8 0.5 10.7 4.4 3.4 1 1 0 3 3 3 0 Uncharacterized conserved protein ApoO PF09769.9 EKE37606.1 - 1 9.3 10.0 27 4.7 5.2 3.6 1 1 1 2 2 2 0 Apolipoprotein O HAUS-augmin3 PF14932.6 EKE37606.1 - 1.1 8.8 11.3 5 6.6 4.2 2.9 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 Taxilin PF09728.9 EKE37606.1 - 1.3 8.1 19.5 1.4 8.0 11.3 2.6 1 1 0 1 1 1 0 Myosin-like coiled-coil protein DUF16 PF01519.16 EKE37606.1 - 1.4 9.4 21.7 3.9 8.0 2.0 2.9 2 1 1 3 3 3 0 Protein of unknown function DUF16 Goodbye PF17109.5 EKE37606.1 - 1.6 9.2 14.1 58 4.2 8.8 3.4 1 1 1 2 2 2 0 fungal STAND N-terminal Goodbye domain Dna2 PF08696.11 EKE37606.1 - 1.7 8.4 11.4 2.9 7.7 0.4 2.8 1 1 3 4 4 3 0 DNA replication factor Dna2 DUF1664 PF07889.12 EKE37606.1 - 1.9 8.6 18.3 2.5 8.2 8.1 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) PRKCSH-like PF12999.7 EKE37606.1 - 2.9 7.7 14.0 1.4 8.7 5.2 2.6 1 1 0 2 2 2 0 Glucosidase II beta subunit-like DUF725 PF05267.12 EKE37606.1 - 3.1 7.8 7.7 6.1 6.8 1.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF725) ZYG-11_interact PF05884.12 EKE37606.1 - 3.3 7.1 9.3 3.3e+02 0.5 9.3 2.3 1 1 0 1 1 1 0 Interactor of ZYG-11 Spc7 PF08317.11 EKE37606.1 - 4.2 6.2 10.7 5.5 5.8 4.8 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Phage_holin_7_1 PF16081.5 EKE37606.1 - 4.3 7.5 8.3 1.3 9.2 4.3 2.1 1 1 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Snapin_Pallidin PF14712.6 EKE37606.1 - 4.6 7.7 12.1 3.3 8.2 0.1 3.4 3 1 0 3 3 2 0 Snapin/Pallidin Peptidase_C65 PF10275.9 EKE37606.1 - 6.1 6.2 9.9 1 8.7 0.2 2.5 2 1 1 3 3 3 0 Peptidase C65 Otubain PIN_8 PF18476.1 EKE37606.1 - 6.3 6.6 15.0 4.1 7.2 7.0 2.3 1 1 2 3 3 3 0 PIN like domain Phasin_2 PF09361.10 EKE37606.1 - 7.6 6.9 12.2 49 4.3 0.9 3.2 1 1 2 3 3 3 0 Phasin protein ParB PF08775.10 EKE37606.1 - 8.2 6.9 16.8 7.5 7.0 3.8 3.1 1 1 2 3 3 3 0 ParB family TMEM154 PF15102.6 EKE37607.1 - 0.00072 19.5 0.6 0.0015 18.4 0.6 1.5 1 0 0 1 1 1 1 TMEM154 protein family Peptidase_S41 PF03572.18 EKE37607.1 - 0.0045 16.6 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase family S41 UL45 PF05473.12 EKE37607.1 - 0.016 14.9 0.0 0.027 14.1 0.0 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Mid2 PF04478.12 EKE37607.1 - 0.037 13.8 0.1 0.1 12.5 0.1 1.7 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Herpes_gE PF02480.16 EKE37607.1 - 0.043 12.6 0.0 0.075 11.8 0.0 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E PRIMA1 PF16101.5 EKE37607.1 - 0.1 12.7 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF1533 PF07550.11 EKE37607.1 - 0.13 12.2 2.5 0.21 11.5 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1533) DUF4194 PF13835.6 EKE37607.1 - 0.14 11.9 0.0 1.7 8.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4194) DUF3586 PF12131.8 EKE37609.1 - 0.054 13.7 0.7 0.054 13.7 0.7 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3586) CH PF00307.31 EKE37610.1 - 8.6e-05 22.7 0.8 0.00051 20.2 0.0 2.7 2 0 0 2 2 2 1 Calponin homology (CH) domain TLD PF07534.16 EKE37610.1 - 0.0072 16.6 1.3 0.088 13.0 0.3 2.5 2 0 0 2 2 2 1 TLD Pkinase_Tyr PF07714.17 EKE37611.1 - 2.7e-37 128.5 0.1 8.8e-37 126.8 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37611.1 - 7.3e-35 120.6 0.0 7.3e-35 120.6 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Myotub-related PF06602.14 EKE37611.1 - 2.5e-21 76.0 5.3 6e-21 74.8 5.3 1.7 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain LRR_8 PF13855.6 EKE37611.1 - 2.4e-12 46.4 23.7 0.00012 21.7 0.8 4.8 3 1 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EKE37611.1 - 1.4e-11 44.4 29.3 1.3e-05 25.4 2.1 6.0 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EKE37611.1 - 0.075 13.6 24.5 15 6.6 0.2 8.1 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_6 PF13516.6 EKE37611.1 - 0.5 10.5 27.7 3.9 7.8 0.4 7.6 9 0 0 9 9 9 0 Leucine Rich repeat ING PF12998.7 EKE37613.1 - 0.034 14.7 4.4 0.034 14.7 4.4 2.2 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding RapA_C PF12137.8 EKE37613.1 - 0.11 11.5 9.3 0.012 14.6 4.6 1.7 2 0 0 2 2 2 0 RNA polymerase recycling family C-terminal Med21 PF11221.8 EKE37613.1 - 0.49 10.7 10.2 0.9 9.8 1.3 2.6 2 0 0 2 2 2 0 Subunit 21 of Mediator complex Raco_middle PF17651.1 EKE37613.1 - 0.81 9.4 3.7 0.88 9.2 2.0 1.9 1 1 1 2 2 2 0 RACo middle region Phasin PF05597.11 EKE37613.1 - 4.2 7.4 11.7 1.4 9.0 7.5 2.1 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) AAA PF00004.29 EKE37614.1 - 4.3e-43 146.9 0.0 8.9e-43 145.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKE37614.1 - 2e-10 40.3 0.1 4.1e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EKE37614.1 - 6.4e-07 29.2 0.0 1.3e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EKE37614.1 - 1.7e-06 28.3 0.0 4.1e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EKE37614.1 - 7.9e-06 26.2 0.1 0.0097 16.2 0.0 2.6 1 1 1 2 2 2 2 AAA domain RuvB_N PF05496.12 EKE37614.1 - 1.9e-05 24.5 0.0 4.3e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EKE37614.1 - 2.5e-05 24.7 0.2 0.001 19.5 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EKE37614.1 - 3.2e-05 23.2 0.0 6.5e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EKE37614.1 - 6.5e-05 22.9 0.1 0.00038 20.5 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EKE37614.1 - 0.0016 19.0 0.1 0.0054 17.3 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.6 EKE37614.1 - 0.0021 18.1 0.0 0.005 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EKE37614.1 - 0.0026 17.5 0.0 0.0063 16.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EKE37614.1 - 0.0028 17.5 0.1 0.089 12.7 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EKE37614.1 - 0.0029 16.9 0.0 0.0057 15.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EKE37614.1 - 0.0033 17.6 0.0 0.0073 16.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EKE37614.1 - 0.0065 15.7 0.0 0.4 9.8 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain RNA_helicase PF00910.22 EKE37614.1 - 0.0065 16.8 0.0 0.015 15.7 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 EKE37614.1 - 0.0069 15.8 0.2 0.023 14.1 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EKE37614.1 - 0.014 15.6 0.0 0.03 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EKE37614.1 - 0.026 14.0 0.1 0.1 12.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein ATPase PF06745.13 EKE37614.1 - 0.027 13.8 0.1 0.89 8.9 0.1 2.4 1 1 1 2 2 2 0 KaiC AAA_24 PF13479.6 EKE37614.1 - 0.038 13.7 2.0 0.068 12.9 0.2 2.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EKE37614.1 - 0.053 14.0 0.5 0.28 11.7 0.1 2.6 2 1 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 EKE37614.1 - 0.055 13.0 0.0 0.16 11.4 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 EKE37614.1 - 0.085 12.6 0.2 0.28 10.9 0.2 1.9 1 1 0 1 1 1 0 AAA domain DUF1128 PF06569.11 EKE37614.1 - 0.086 12.8 0.6 0.35 10.9 0.0 2.4 3 0 0 3 3 1 0 Protein of unknown function (DUF1128) ATPase_2 PF01637.18 EKE37614.1 - 0.092 12.6 1.2 1.5 8.7 0.0 2.9 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EKE37614.1 - 0.12 12.0 0.4 0.39 10.2 0.2 1.9 1 1 1 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EKE37614.1 - 0.13 11.3 0.0 0.26 10.4 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TsaE PF02367.17 EKE37614.1 - 0.14 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE XhlA PF10779.9 EKE37615.1 - 0.019 15.1 1.7 0.019 15.1 1.7 2.6 3 0 0 3 3 3 0 Haemolysin XhlA EMP24_GP25L PF01105.24 EKE37615.1 - 0.025 14.5 1.8 0.25 11.3 0.2 2.2 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Med18 PF09637.10 EKE37615.1 - 0.044 13.6 1.4 0.16 11.8 1.4 2.0 1 1 0 1 1 1 0 Med18 protein ABC2_membrane_3 PF12698.7 EKE37615.1 - 0.22 10.6 5.6 0.31 10.1 4.6 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein GP41 PF00517.17 EKE37615.1 - 0.31 10.9 6.3 0.79 9.6 1.7 2.3 2 0 0 2 2 2 0 Retroviral envelope protein LRRC37AB_C PF14914.6 EKE37615.1 - 1.1 9.2 5.4 2.1 8.2 0.7 2.3 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain ETRAMP PF09716.10 EKE37615.1 - 1.5 8.9 13.8 0.11 12.5 3.9 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF2315 PF10231.9 EKE37615.1 - 2.7 8.1 7.7 0.22 11.6 2.0 2.0 2 0 0 2 2 2 0 Apoptogenic protein 1 Alpha_kinase PF02816.18 EKE37616.1 - 7.6e-07 29.4 9.4 2.1e-06 28.0 9.4 1.7 1 0 0 1 1 1 1 Alpha-kinase family Pkinase PF00069.25 EKE37617.1 - 2.1e-49 168.2 0.9 3.9e-49 167.4 0.9 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37617.1 - 3.7e-49 167.3 0.3 5.8e-49 166.7 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37617.1 - 2.9e-07 29.6 0.0 5.1e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase VSP PF03302.13 EKE37617.1 - 1.4e-05 24.2 42.3 1.4e-05 24.2 42.3 10.2 1 1 5 8 8 8 4 Giardia variant-specific surface protein RasGEF PF00617.19 EKE37618.1 - 9.5e-17 61.8 6.7 9.5e-17 61.8 6.7 3.1 3 0 0 3 3 3 1 RasGEF domain DnaJ PF00226.31 EKE37619.1 - 3e-25 88.1 4.0 4.8e-25 87.5 4.0 1.3 1 0 0 1 1 1 1 DnaJ domain Peptidase_C1 PF00112.23 EKE37622.1 - 6.4e-33 114.7 0.0 1e-32 114.0 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE37622.1 - 0.0094 16.4 1.4 0.02 15.3 1.4 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) TAL_FSA PF00923.19 EKE37622.1 - 0.013 14.8 0.0 0.031 13.6 0.0 1.6 2 0 0 2 2 2 0 Transaldolase/Fructose-6-phosphate aldolase Mga PF05043.13 EKE37622.1 - 0.056 14.0 0.9 0.12 13.0 0.9 1.6 1 1 0 1 1 1 0 Mga helix-turn-helix domain 7tm_3 PF00003.22 EKE37623.1 - 0.0061 16.3 0.7 0.013 15.2 0.7 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Motile_Sperm PF00635.26 EKE37623.1 - 0.0095 15.8 0.1 0.021 14.6 0.1 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain EGF_2 PF07974.13 EKE37623.1 - 0.021 15.2 11.2 0.021 15.2 11.2 5.0 3 1 1 4 4 4 0 EGF-like domain LIM PF00412.22 EKE37624.1 - 3.4e-12 46.4 23.1 7.7e-09 35.7 8.8 3.8 3 1 1 4 4 4 2 LIM domain zinc_ribbon_2 PF13240.6 EKE37624.1 - 7.3e-10 38.2 5.5 7.3e-10 38.2 5.5 4.4 4 0 0 4 4 4 2 zinc-ribbon domain DZR PF12773.7 EKE37624.1 - 8e-09 35.4 18.4 3.7e-06 26.9 8.4 3.4 1 1 1 2 2 2 2 Double zinc ribbon zf-ribbon_3 PF13248.6 EKE37624.1 - 8.7e-07 28.1 3.5 8.7e-07 28.1 3.5 4.4 4 0 0 4 4 4 2 zinc-ribbon domain Nudix_N_2 PF14803.6 EKE37624.1 - 0.0014 18.5 18.7 0.1 12.5 0.1 5.3 5 0 0 5 5 5 2 Nudix N-terminal DUF4428 PF14471.6 EKE37624.1 - 0.014 15.3 17.2 0.11 12.4 5.0 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4428) zinc_ribbon_15 PF17032.5 EKE37624.1 - 0.015 16.1 2.3 0.015 16.1 2.3 3.5 2 1 0 2 2 1 0 zinc-ribbon family zf-C3HC4_3 PF13920.6 EKE37624.1 - 0.044 13.6 0.4 0.044 13.6 0.4 3.8 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf_C2H2_13 PF18508.1 EKE37624.1 - 0.054 13.1 0.1 0.054 13.1 0.1 4.1 5 0 0 5 5 5 0 Zinc finger domain YhfH PF14149.6 EKE37624.1 - 0.067 13.2 25.4 0.96 9.5 5.3 5.9 3 2 2 5 5 5 0 YhfH-like protein zf-NADH-PPase PF09297.11 EKE37624.1 - 0.17 11.6 0.1 0.17 11.6 0.1 5.8 7 0 0 7 7 6 0 NADH pyrophosphatase zinc ribbon domain DUF3268 PF11672.8 EKE37624.1 - 0.25 11.7 9.6 0.38 11.1 2.3 2.7 2 1 0 2 2 2 0 zinc-finger-containing domain Zn-ribbon_8 PF09723.10 EKE37624.1 - 0.38 10.9 23.9 3.4 7.9 0.4 4.9 2 2 1 3 3 3 0 Zinc ribbon domain Ogr_Delta PF04606.12 EKE37624.1 - 0.65 10.0 0.0 0.65 10.0 0.0 4.0 4 1 1 5 5 4 0 Ogr/Delta-like zinc finger zf-RRN7 PF11781.8 EKE37624.1 - 1.1 9.0 13.7 4 7.2 0.0 5.2 4 1 1 5 5 5 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 A2L_zn_ribbon PF08792.10 EKE37624.1 - 1.2 8.9 0.1 1.2 8.9 0.1 5.1 5 1 0 5 5 5 0 A2L zinc ribbon domain zf_UBZ PF18439.1 EKE37624.1 - 1.2 8.7 18.4 2.3 7.9 0.1 5.3 4 1 1 5 5 5 0 Ubiquitin-Binding Zinc Finger DUF2256 PF10013.9 EKE37624.1 - 1.4 9.1 0.1 1.4 9.1 0.1 4.5 4 1 1 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-TFIIB PF13453.6 EKE37624.1 - 2.4 7.5 12.8 4 6.9 0.0 4.8 5 0 0 5 5 5 0 Transcription factor zinc-finger TF_Zn_Ribbon PF08271.12 EKE37624.1 - 2.9 7.5 18.2 6.8 6.3 0.2 4.9 5 0 0 5 5 5 0 TFIIB zinc-binding zf-UDP PF14569.6 EKE37624.1 - 5.4 7.2 14.4 3.1 8.0 0.3 3.3 2 1 0 2 2 2 0 Zinc-binding RING-finger FYDLN_acid PF09538.10 EKE37624.1 - 7.6 7.3 10.3 0.17 12.6 2.8 2.1 2 1 0 2 2 1 0 Protein of unknown function (FYDLN_acid) TMEM154 PF15102.6 EKE37625.1 - 0.00032 20.6 2.8 0.00032 20.6 2.8 1.8 2 0 0 2 2 2 1 TMEM154 protein family Insulin_TMD PF17870.1 EKE37625.1 - 0.062 13.4 2.5 0.21 11.7 2.5 1.9 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Collectrin PF16959.5 EKE37625.1 - 0.063 13.0 1.7 0.32 10.7 1.7 2.2 1 0 0 1 1 1 0 Renal amino acid transporter AAA PF00004.29 EKE37626.1 - 2.3e-28 99.3 0.0 7.1e-28 97.7 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EKE37626.1 - 9.4e-05 21.7 0.0 0.00017 20.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EKE37626.1 - 0.00014 22.3 0.1 0.00042 20.7 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EKE37626.1 - 0.00021 20.9 0.3 0.36 10.4 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_22 PF13401.6 EKE37626.1 - 0.00088 19.6 0.6 0.047 14.0 0.1 2.4 1 1 1 2 2 2 1 AAA domain Rad17 PF03215.15 EKE37626.1 - 0.0011 19.0 0.0 0.0025 17.8 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain TniB PF05621.11 EKE37626.1 - 0.0011 18.4 0.0 0.0029 17.0 0.0 1.6 2 0 0 2 2 2 1 Bacterial TniB protein ATPase_2 PF01637.18 EKE37626.1 - 0.0029 17.5 0.2 0.013 15.4 0.0 2.1 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EKE37626.1 - 0.0032 17.4 0.0 0.31 10.9 0.0 2.4 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 EKE37626.1 - 0.0071 16.7 0.0 0.019 15.4 0.0 1.8 1 0 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 EKE37626.1 - 0.0072 16.8 0.0 0.022 15.2 0.0 1.8 2 0 0 2 2 1 1 ABC transporter AAA_24 PF13479.6 EKE37626.1 - 0.0077 16.0 0.0 0.045 13.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EKE37626.1 - 0.01 15.8 0.0 0.057 13.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EKE37626.1 - 0.021 14.6 0.0 0.049 13.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EKE37626.1 - 0.023 15.2 1.2 0.089 13.3 0.0 2.3 2 1 1 3 3 3 0 AAA domain AAA_18 PF13238.6 EKE37626.1 - 0.029 14.9 0.0 0.19 12.3 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_14 PF13173.6 EKE37626.1 - 0.029 14.4 0.0 0.081 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EKE37626.1 - 0.064 13.4 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ribosomal_S27e PF01667.17 EKE37628.1 - 1.9e-28 97.9 4.0 2.2e-28 97.7 4.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 EKE37628.1 - 9.6e-06 25.0 0.2 1.3e-05 24.6 0.2 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.6 EKE37628.1 - 0.001 18.4 5.6 0.046 13.2 5.6 2.3 1 1 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EKE37628.1 - 0.0011 18.6 3.0 0.4 10.4 0.5 2.3 2 0 0 2 2 2 2 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 EKE37628.1 - 0.0017 18.3 0.3 0.0023 17.8 0.3 1.3 1 0 0 1 1 1 1 Putative transposase DNA-binding domain DZR PF12773.7 EKE37628.1 - 0.0019 18.2 3.6 0.024 14.7 4.7 1.9 1 1 1 2 2 2 2 Double zinc ribbon Zn-ribbon_8 PF09723.10 EKE37628.1 - 0.0076 16.3 3.1 0.023 14.8 3.1 1.8 1 1 0 1 1 1 1 Zinc ribbon domain HypA PF01155.19 EKE37628.1 - 0.012 15.7 1.3 0.014 15.4 1.3 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1595 PF12760.7 EKE37628.1 - 0.014 15.3 2.0 0.02 14.8 2.0 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-FPG_IleRS PF06827.14 EKE37628.1 - 0.027 14.3 1.3 0.098 12.5 0.1 2.1 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf-ACC PF17848.1 EKE37628.1 - 0.028 14.5 4.5 0.16 12.1 0.6 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain PhnA_Zn_Ribbon PF08274.12 EKE37628.1 - 0.036 14.0 0.2 0.062 13.3 0.2 1.4 1 0 0 1 1 1 0 PhnA Zinc-Ribbon Mu-like_Com PF10122.9 EKE37628.1 - 0.047 13.2 0.3 0.047 13.2 0.3 2.1 1 1 1 2 2 2 0 Mu-like prophage protein Com zinc-ribbons_6 PF07191.12 EKE37628.1 - 0.05 13.6 3.7 0.11 12.5 3.7 1.6 1 1 0 1 1 1 0 zinc-ribbons A2L_zn_ribbon PF08792.10 EKE37628.1 - 0.057 13.1 1.6 2.1 8.2 0.1 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain Nop10p PF04135.12 EKE37628.1 - 0.058 13.5 1.3 0.4 10.7 0.1 2.2 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family HECT_2 PF09814.9 EKE37628.1 - 0.061 12.2 0.3 0.067 12.1 0.3 1.1 1 0 0 1 1 1 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding ADK_lid PF05191.14 EKE37628.1 - 0.077 13.0 3.2 0.39 10.7 3.2 2.0 1 1 0 1 1 1 0 Adenylate kinase, active site lid DUF2614 PF11023.8 EKE37628.1 - 0.083 13.0 0.1 0.091 12.9 0.1 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain Lar_restr_allev PF14354.6 EKE37628.1 - 0.085 13.2 1.6 0.14 12.5 1.6 1.5 1 1 0 1 1 1 0 Restriction alleviation protein Lar DUF2752 PF10825.8 EKE37628.1 - 0.087 12.9 0.4 0.087 12.9 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2752) zf-Mss51 PF13824.6 EKE37628.1 - 0.089 12.9 3.1 1.3 9.2 3.4 2.0 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-TFIIB PF13453.6 EKE37628.1 - 0.098 12.0 2.6 0.17 11.2 2.6 1.5 1 1 0 1 1 1 0 Transcription factor zinc-finger TFIIS_C PF01096.18 EKE37628.1 - 0.11 12.3 0.4 0.11 12.3 0.4 2.4 2 1 1 3 3 2 0 Transcription factor S-II (TFIIS) zinc_ribbon_6 PF14599.6 EKE37628.1 - 0.12 12.4 1.4 0.29 11.2 1.4 1.6 1 1 0 1 1 1 0 Zinc-ribbon Nudix_N_2 PF14803.6 EKE37628.1 - 0.18 11.8 4.4 4.6 7.2 0.4 2.4 2 0 0 2 2 2 0 Nudix N-terminal CpXC PF14353.6 EKE37628.1 - 0.24 11.4 4.2 0.43 10.6 0.2 2.1 1 1 1 2 2 2 0 CpXC protein zf-CCHC_3 PF13917.6 EKE37628.1 - 0.25 11.4 0.5 0.25 11.4 0.5 2.6 3 0 0 3 3 3 0 Zinc knuckle zf_UBZ PF18439.1 EKE37628.1 - 0.25 11.0 5.7 2.6 7.7 0.1 2.6 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf_C2H2_13 PF18508.1 EKE37628.1 - 0.43 10.2 3.3 0.67 9.6 0.1 2.5 3 0 0 3 3 3 0 Zinc finger domain Zn_ribbon_recom PF13408.6 EKE37628.1 - 0.49 11.0 4.4 30 5.2 4.4 2.1 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain Zn_ribbon_SprT PF17283.2 EKE37628.1 - 0.82 9.6 8.5 0.094 12.6 3.8 1.8 2 1 0 2 2 2 0 SprT-like zinc ribbon domain zinc_ribbon_4 PF13717.6 EKE37628.1 - 1.4 8.9 9.5 23 5.0 6.0 2.6 2 1 0 2 2 1 0 zinc-ribbon domain zf-C4_Topoisom PF01396.19 EKE37628.1 - 1.7 8.5 8.8 1.1 9.0 0.5 2.5 3 0 0 3 3 2 0 Topoisomerase DNA binding C4 zinc finger Rap_GAP PF02145.15 EKE37629.1 - 3.1e-52 176.8 1.9 5.6e-52 176.0 1.9 1.4 1 0 0 1 1 1 1 Rap/ran-GAP DUF4568 PF15132.6 EKE37629.1 - 0.031 13.7 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4568) DHHC PF01529.20 EKE37630.1 - 4.6e-35 120.6 18.5 4.6e-35 120.6 18.5 2.2 2 1 0 2 2 2 1 DHHC palmitoyltransferase Sdh_cyt PF01127.22 EKE37630.1 - 0.0038 17.3 0.6 0.0038 17.3 0.6 1.9 2 0 0 2 2 2 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF3341 PF11821.8 EKE37630.1 - 0.11 12.1 2.8 0.18 11.4 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) GTP_EFTU PF00009.27 EKE37631.1 - 1.6e-43 148.5 0.0 3.8e-43 147.3 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EKE37631.1 - 2.1e-26 92.4 1.0 2.9e-25 88.7 0.0 3.0 4 0 0 4 4 4 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EKE37631.1 - 4e-06 27.1 0.7 1.8e-05 25.0 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EKE37631.1 - 0.00094 19.2 0.1 0.0058 16.7 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF4464 PF14713.6 EKE37631.1 - 0.014 15.0 0.4 0.024 14.2 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4464) G-alpha PF00503.20 EKE37631.1 - 0.055 12.6 0.5 0.16 11.1 0.5 1.7 1 1 1 2 2 2 0 G-protein alpha subunit PerC PF06069.11 EKE37633.1 - 0.039 14.2 0.0 0.12 12.7 0.0 1.7 1 1 1 2 2 2 0 PerC transcriptional activator Pkinase PF00069.25 EKE37634.1 - 3e-91 305.5 1.6 1.2e-52 179.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37634.1 - 8.2e-59 199.0 0.2 1.5e-30 106.4 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EKE37634.1 - 6.2e-05 22.5 0.0 0.16 11.2 0.0 2.5 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EKE37634.1 - 0.17 11.8 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family AAA_11 PF13086.6 EKE37635.1 - 5.3e-75 252.6 6.0 5.3e-75 252.6 6.0 4.2 2 1 2 4 4 4 1 AAA domain AAA_12 PF13087.6 EKE37635.1 - 4.1e-61 206.1 0.0 4.1e-61 206.1 0.0 3.8 3 1 1 4 4 4 1 AAA domain AAA_30 PF13604.6 EKE37635.1 - 4e-08 33.2 0.0 0.00012 21.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EKE37635.1 - 9.7e-06 26.0 4.6 2.2e-05 24.8 1.2 2.8 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EKE37635.1 - 0.0015 19.1 15.5 0.0015 19.1 15.5 4.8 3 1 1 4 4 4 1 AAA domain AAA_25 PF13481.6 EKE37635.1 - 0.17 11.5 0.3 0.61 9.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF948 PF06103.11 EKE37635.1 - 5.3 7.4 7.8 2.9 8.2 4.3 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) RecR PF02132.15 EKE37636.1 - 0.26 10.9 4.0 0.088 12.4 0.6 1.9 2 0 0 2 2 2 0 RecR protein TRM PF02005.16 EKE37637.1 - 2.9e-110 369.0 0.0 3.6e-110 368.7 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase PhnA_Zn_Ribbon PF08274.12 EKE37637.1 - 0.027 14.4 0.1 0.074 13.0 0.1 1.8 1 0 0 1 1 1 0 PhnA Zinc-Ribbon Cons_hypoth95 PF03602.15 EKE37637.1 - 0.052 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 FAD_SOX PF18371.1 EKE37638.1 - 0.026 14.9 4.0 1.9 8.9 0.2 4.3 3 1 1 4 4 4 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Glycos_transf_2 PF00535.26 EKE37638.1 - 0.075 12.8 0.1 0.3 10.9 0.0 2.0 1 1 0 1 1 1 0 Glycosyl transferase family 2 GP3_package PF16677.5 EKE37638.1 - 0.39 10.9 4.6 0.34 11.1 1.0 2.8 2 0 0 2 2 2 0 DNA-packaging protein gp3 Vac14_Fab1_bd PF12755.7 EKE37638.1 - 1.4 9.6 12.0 3 8.5 0.9 5.3 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region OSCP PF00213.18 EKE37638.1 - 2.1 8.4 8.4 0.16 12.1 0.9 3.2 3 0 0 3 3 3 0 ATP synthase delta (OSCP) subunit DUF2009 PF09418.10 EKE37639.1 - 4.8e-198 658.8 1.1 4.8e-198 658.8 1.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2009) Gal_GalNac_35kD PF17337.2 EKE37640.1 - 1.3e-108 362.2 9.7 1.6e-108 361.9 9.7 1.1 1 0 0 1 1 1 1 Galactose-inhibitable lectin 35 kDa subunit Adaptin_N PF01602.20 EKE37641.1 - 5.6e-129 431.1 18.1 6.7e-129 430.8 18.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EKE37641.1 - 6.9e-52 175.8 3.5 6.9e-52 175.8 3.5 3.2 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKE37641.1 - 6.6e-18 64.9 2.2 2.7e-05 24.5 0.0 5.3 3 1 2 5 5 5 4 HEAT repeats Cnd3 PF12719.7 EKE37641.1 - 9.6e-09 34.8 5.6 3.6e-07 29.7 0.8 2.9 3 0 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 EKE37641.1 - 4.4e-08 32.7 11.7 0.00061 19.8 0.0 6.5 8 0 0 8 8 8 2 HEAT repeat HEAT_EZ PF13513.6 EKE37641.1 - 0.0062 17.0 3.7 20 5.8 0.0 5.5 7 0 0 7 7 7 0 HEAT-like repeat Arm PF00514.23 EKE37641.1 - 0.013 15.5 0.7 29 4.9 0.1 4.8 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EKE37641.1 - 0.015 15.4 4.4 0.77 10.0 0.0 4.5 2 2 3 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 RIG-I_C-RD PF11648.8 EKE37641.1 - 0.044 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 C-terminal domain of RIG-I DNA_alkylation PF08713.11 EKE37641.1 - 0.067 12.9 0.2 0.58 9.8 0.0 2.3 2 0 0 2 2 2 0 DNA alkylation repair enzyme CLASP_N PF12348.8 EKE37641.1 - 0.15 11.6 10.7 3.9 7.0 0.0 4.8 5 1 1 6 6 6 0 CLASP N terminal Pkinase PF00069.25 EKE37642.1 - 1.9e-64 217.6 0.0 2.9e-64 217.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37642.1 - 1.9e-45 155.1 0.0 3e-45 154.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Calpain_III PF01067.22 EKE37642.1 - 2.3e-27 96.0 0.2 9.6e-12 45.4 0.1 3.7 3 0 0 3 3 3 3 Calpain large subunit, domain III Pkinase_fungal PF17667.1 EKE37642.1 - 8.1e-06 24.9 0.1 1.5e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKE37642.1 - 4.4e-05 22.9 0.0 8.6e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pacs-1 PF10254.9 EKE37643.1 - 1e-10 41.2 0.1 1e-10 41.2 0.1 2.8 3 0 0 3 3 3 2 PACS-1 cytosolic sorting protein Glutaredoxin2_C PF04399.13 EKE37644.1 - 4.4 7.2 7.1 22 4.9 0.5 3.5 3 0 0 3 3 3 0 Glutaredoxin 2, C terminal domain PPC PF04151.15 EKE37645.1 - 6.9e-05 23.9 1.1 0.00025 22.1 0.3 2.5 2 0 0 2 2 2 1 Bacterial pre-peptidase C-terminal domain RRM_1 PF00076.22 EKE37647.1 - 1.7e-08 34.1 1.7 2.4e-08 33.7 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKE37647.1 - 4.6e-05 23.2 0.5 0.00012 21.9 0.5 1.6 1 0 0 1 1 1 1 Occluded RNA-recognition motif HAD_2 PF13419.6 EKE37647.1 - 0.069 13.2 10.6 0.42 10.7 0.5 2.5 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase SPRY PF00622.28 EKE37648.1 - 5.7e-14 52.3 0.2 7.9e-14 51.8 0.2 1.2 1 0 0 1 1 1 1 SPRY domain Sybindin PF04099.12 EKE37648.1 - 0.05 13.5 0.5 0.34 10.8 0.1 2.4 2 1 1 3 3 3 0 Sybindin-like family LAMTOR5 PF16672.5 EKE37648.1 - 0.099 12.6 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 TMF_DNA_bd PF12329.8 EKE37648.1 - 0.65 10.0 6.7 6 6.9 6.7 2.3 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding BBP1_N PF15271.6 EKE37649.1 - 0.0095 16.7 0.7 0.012 16.5 0.7 1.3 1 0 0 1 1 1 1 Spindle pole body component BBP1, Mps2-binding protein Myb_DNA-bind_6 PF13921.6 EKE37649.1 - 0.082 13.2 0.7 2.3 8.5 0.0 2.4 2 1 0 2 2 2 0 Myb-like DNA-binding domain EMP24_GP25L PF01105.24 EKE37650.1 - 4.9e-17 62.5 0.1 5.7e-17 62.3 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD LPP20 PF02169.16 EKE37650.1 - 0.15 12.4 0.1 0.24 11.7 0.1 1.3 1 0 0 1 1 1 0 LPP20 lipoprotein DDE_Tnp_IS1595 PF12762.7 EKE37651.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 ISXO2-like transposase domain Ribosomal_L38e PF01781.18 EKE37652.1 - 3.7e-23 81.4 2.9 4.4e-23 81.2 2.9 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Lipase_3 PF01764.25 EKE37653.1 - 2.8e-20 72.6 0.0 6.4e-20 71.5 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EKE37653.1 - 0.01 15.2 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 BAR_3_WASP_bdg PF10456.9 EKE37653.1 - 0.12 11.9 0.4 0.96 8.9 0.1 2.2 2 0 0 2 2 2 0 WASP-binding domain of Sorting nexin protein Sec10 PF07393.11 EKE37654.1 - 5.8e-53 180.4 21.4 2.1e-29 102.5 14.7 2.1 1 1 1 2 2 2 2 Exocyst complex component Sec10 COG5 PF10392.9 EKE37654.1 - 0.28 11.3 10.0 0.11 12.7 0.4 3.5 4 0 0 4 4 4 0 Golgi transport complex subunit 5 Baculo_PEP_C PF04513.12 EKE37654.1 - 0.62 10.1 11.6 0.2 11.7 0.2 3.8 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DSPc PF00782.20 EKE37655.1 - 1.9e-36 124.8 0.6 4.9e-36 123.5 0.2 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain LRR_4 PF12799.7 EKE37655.1 - 6.3e-12 45.5 22.2 2.3e-06 27.8 0.8 6.9 2 2 4 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE37655.1 - 5.2e-09 35.7 21.8 8.6e-05 22.2 3.3 5.5 4 2 0 4 4 4 2 Leucine rich repeat Y_phosphatase PF00102.27 EKE37655.1 - 0.0017 18.0 0.0 0.0034 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 EKE37655.1 - 0.0021 17.7 0.1 0.0056 16.3 0.1 1.7 1 0 0 1 1 1 1 Tyrosine phosphatase family LRR_9 PF14580.6 EKE37655.1 - 1.4 8.4 12.1 1.1 8.7 0.8 3.6 1 1 3 4 4 4 0 Leucine-rich repeat LRR_6 PF13516.6 EKE37655.1 - 1.8 8.8 27.7 8.1 6.8 0.0 8.1 8 1 2 10 10 10 0 Leucine Rich repeat PDCD2_C PF04194.13 EKE37656.1 - 2.1e-21 76.8 4.8 2.1e-21 76.8 4.8 2.0 2 1 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain RecR PF02132.15 EKE37656.1 - 0.27 10.8 4.5 3.2 7.4 0.5 2.6 2 0 0 2 2 2 0 RecR protein Desulfoferrod_N PF06397.12 EKE37656.1 - 0.28 10.8 0.2 0.28 10.8 0.2 3.9 4 0 0 4 4 4 0 Desulfoferrodoxin, N-terminal domain RRP7 PF12923.7 EKE37656.1 - 0.36 11.0 5.5 4.8 7.3 0.4 2.2 1 1 1 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DNA_pol3_delta2 PF13177.6 EKE37658.1 - 1.2e-17 64.1 0.1 6.9e-14 51.9 0.1 2.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EKE37658.1 - 1.7e-17 64.1 0.1 3.6e-17 63.0 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EKE37658.1 - 1.6e-11 44.4 0.5 1.2e-10 41.7 0.0 2.3 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_22 PF13401.6 EKE37658.1 - 2.2e-07 31.2 0.5 1.2e-05 25.6 0.5 2.3 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 EKE37658.1 - 5.5e-07 29.5 0.3 9.1e-07 28.8 0.3 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EKE37658.1 - 1.4e-06 28.3 0.0 2.7e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 EKE37658.1 - 4.2e-06 26.6 0.0 2e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EKE37658.1 - 8.5e-06 25.1 0.0 1.9e-05 24.0 0.0 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EKE37658.1 - 1.4e-05 25.6 0.0 4.1e-05 24.1 0.0 1.7 1 1 1 2 2 1 1 AAA domain AAA_16 PF13191.6 EKE37658.1 - 2.1e-05 25.0 0.0 0.00025 21.5 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_assoc_2 PF16193.5 EKE37658.1 - 3.4e-05 24.1 0.0 8.7e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain ResIII PF04851.15 EKE37658.1 - 3.5e-05 23.9 0.3 0.0018 18.3 0.3 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_14 PF13173.6 EKE37658.1 - 4.3e-05 23.6 0.0 8.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EKE37658.1 - 9.2e-05 22.3 0.4 0.00025 20.9 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 EKE37658.1 - 0.0001 22.1 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EKE37658.1 - 0.00037 20.5 0.1 0.0024 17.9 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EKE37658.1 - 0.00038 20.8 0.2 0.0016 18.8 0.1 2.0 2 1 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 EKE37658.1 - 0.00053 19.4 0.0 0.038 13.4 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 EKE37658.1 - 0.00064 19.0 0.0 0.062 12.5 0.0 2.1 1 1 1 2 2 2 1 NB-ARC domain AAA_7 PF12775.7 EKE37658.1 - 0.00073 19.1 0.0 0.0016 18.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 EKE37658.1 - 0.0011 18.8 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TniB PF05621.11 EKE37658.1 - 0.0016 17.9 0.0 0.0039 16.6 0.0 1.6 1 0 0 1 1 1 1 Bacterial TniB protein DEAD PF00270.29 EKE37658.1 - 0.0043 16.8 1.7 0.093 12.5 0.7 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.16 EKE37658.1 - 0.0045 16.5 0.3 0.64 9.4 0.0 2.3 1 1 1 2 2 2 1 PhoH-like protein AAA_33 PF13671.6 EKE37658.1 - 0.0053 16.9 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EKE37658.1 - 0.0062 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EKE37658.1 - 0.014 14.6 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase_2 PF01637.18 EKE37658.1 - 0.017 15.0 0.0 0.025 14.5 0.0 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EKE37658.1 - 0.025 14.9 0.0 0.044 14.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 EKE37658.1 - 0.027 14.3 0.0 0.084 12.7 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EKE37658.1 - 0.031 13.6 0.7 0.44 9.8 0.3 2.3 1 1 1 2 2 2 0 KaiC T2SSE PF00437.20 EKE37658.1 - 0.044 12.8 0.1 0.15 11.1 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein SNF2_N PF00176.23 EKE37658.1 - 0.068 11.9 0.5 1.7 7.3 0.0 2.6 2 1 1 3 3 3 0 SNF2 family N-terminal domain DUF87 PF01935.17 EKE37658.1 - 0.11 12.6 0.3 1.2 9.2 0.3 2.4 1 1 0 1 1 1 0 Helicase HerA, central domain AAA_25 PF13481.6 EKE37658.1 - 0.15 11.6 0.3 0.34 10.4 0.3 1.6 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EKE37658.1 - 0.32 11.4 1.4 0.47 10.9 0.2 2.0 2 1 0 2 2 2 0 AAA domain Fer4 PF00037.27 EKE37659.1 - 5e-11 41.9 14.0 7.7e-06 25.5 4.0 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EKE37659.1 - 1.1e-07 32.4 13.3 1.4e-06 28.8 13.6 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 EKE37659.1 - 2.1e-07 30.9 27.9 2.5e-05 24.3 16.6 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EKE37659.1 - 8.4e-07 29.1 13.8 1.4e-06 28.4 13.8 1.4 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EKE37659.1 - 8.5e-07 28.8 15.2 0.00016 21.6 4.2 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EKE37659.1 - 1.7e-06 27.7 15.0 0.00012 21.9 2.7 2.6 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_16 PF13484.6 EKE37659.1 - 3.6e-06 27.8 12.7 0.0071 17.3 2.4 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 EKE37659.1 - 9.7e-06 25.6 15.3 4e-05 23.7 15.8 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 EKE37659.1 - 2.8e-05 24.5 16.5 0.0099 16.3 5.4 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 EKE37659.1 - 3.6e-05 24.2 15.3 0.012 16.1 2.6 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_3 PF12798.7 EKE37659.1 - 0.00018 22.2 16.7 0.028 15.3 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EKE37659.1 - 0.00036 20.8 15.9 0.028 14.9 3.3 2.4 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_18 PF13746.6 EKE37659.1 - 0.0099 16.1 13.4 0.016 15.4 13.4 1.3 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_13 PF13370.6 EKE37659.1 - 0.61 10.7 15.4 0.61 10.7 2.8 2.7 2 1 1 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 EKE37659.1 - 0.65 10.9 12.0 0.25 12.2 1.8 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain zf-CXXC PF02008.20 EKE37659.1 - 1 9.5 14.8 3.4 7.8 3.8 2.1 1 1 1 2 2 2 0 CXXC zinc finger domain ABC_tran PF00005.27 EKE37660.1 - 2.1e-30 106.0 0.1 3.5e-30 105.3 0.1 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EKE37660.1 - 0.00043 19.8 1.6 0.0053 16.2 0.1 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EKE37660.1 - 0.0007 19.5 2.3 0.0059 16.5 0.1 2.4 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EKE37660.1 - 0.0018 18.4 0.1 0.056 13.7 0.1 2.5 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EKE37660.1 - 0.049 14.1 0.5 0.049 14.1 0.5 2.2 2 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EKE37660.1 - 0.066 13.1 0.2 0.066 13.1 0.2 2.1 2 1 1 3 3 3 0 RsgA GTPase AAA_29 PF13555.6 EKE37660.1 - 0.17 11.6 0.6 0.35 10.7 0.2 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EKE37660.1 - 0.78 10.0 2.8 4.6 7.5 2.8 2.2 1 1 0 1 1 1 0 AAA domain HNOB PF07700.15 EKE37661.1 - 0.071 13.1 3.1 5.3 7.0 0.1 2.2 2 0 0 2 2 2 0 Haem-NO-binding DNA_pol3_a_NII PF11490.8 EKE37661.1 - 0.084 12.8 4.4 0.19 11.7 4.4 1.5 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Peptidase_S74 PF13884.6 EKE37663.1 - 6.1e-12 45.7 0.2 1.6e-11 44.3 0.2 1.8 1 0 0 1 1 1 1 Chaperone of endosialidase DUF2207 PF09972.9 EKE37663.1 - 0.0094 14.8 1.1 0.0094 14.8 1.1 2.7 2 1 1 3 3 3 2 Predicted membrane protein (DUF2207) Smr PF01713.21 EKE37664.1 - 0.0027 18.0 0.3 0.011 16.1 0.0 2.0 3 0 0 3 3 3 1 Smr domain OmpH PF03938.14 EKE37664.1 - 0.13 12.6 2.4 0.2 12.0 1.2 1.8 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3955 PF13127.6 EKE37664.1 - 0.21 11.4 3.2 0.32 10.9 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3955) DUF1192 PF06698.11 EKE37664.1 - 0.23 11.6 1.1 0.34 11.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Ras PF00071.22 EKE37665.1 - 1.3e-55 187.4 0.3 1.5e-55 187.2 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37665.1 - 2e-33 115.2 0.1 3.1e-33 114.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37665.1 - 5.9e-14 51.9 0.0 7.4e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE37665.1 - 7.3e-06 26.1 0.0 1e-05 25.6 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE37665.1 - 6.6e-05 22.4 0.1 0.0001 21.8 0.1 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE37665.1 - 9.2e-05 22.1 0.0 0.0019 17.7 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE37665.1 - 0.00075 18.9 0.0 0.0011 18.4 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EKE37665.1 - 0.0042 16.6 0.1 0.33 10.5 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EKE37665.1 - 0.015 15.3 0.0 0.025 14.6 0.0 1.4 1 1 0 1 1 1 0 Dynamin family AAA_24 PF13479.6 EKE37665.1 - 0.023 14.4 0.1 0.19 11.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EKE37665.1 - 0.027 14.5 0.1 0.16 12.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 EKE37665.1 - 0.043 13.2 0.0 0.067 12.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein RsgA_GTPase PF03193.16 EKE37665.1 - 0.057 13.3 0.3 2.4 8.0 0.1 2.4 1 1 2 3 3 3 0 RsgA GTPase AAA_7 PF12775.7 EKE37665.1 - 0.085 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 EKE37665.1 - 0.12 12.7 0.1 0.31 11.3 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EKE37665.1 - 0.18 12.2 0.1 0.33 11.3 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain Rad51 PF08423.11 EKE37666.1 - 3.9e-29 101.7 0.2 4.5e-29 101.5 0.2 1.1 1 0 0 1 1 1 1 Rad51 ATPase PF06745.13 EKE37666.1 - 2.6e-09 36.8 0.2 8.5e-09 35.1 0.1 1.9 2 1 0 2 2 2 1 KaiC AAA_25 PF13481.6 EKE37666.1 - 0.00022 20.9 0.0 0.00062 19.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain RecA PF00154.21 EKE37666.1 - 0.00046 19.7 0.0 0.0036 16.8 0.0 2.0 2 0 0 2 2 2 1 recA bacterial DNA recombination protein ABC_tran PF00005.27 EKE37666.1 - 0.0033 18.0 0.0 0.0056 17.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_24 PF13479.6 EKE37666.1 - 0.0091 15.7 0.0 0.33 10.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EKE37666.1 - 0.01 15.8 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DnaB_C PF03796.15 EKE37666.1 - 0.012 15.0 0.2 0.1 11.9 0.2 2.1 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_22 PF13401.6 EKE37666.1 - 0.041 14.2 0.1 0.085 13.1 0.0 1.6 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EKE37666.1 - 0.041 14.4 0.1 0.18 12.3 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EKE37666.1 - 0.16 12.4 0.0 0.53 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain Clat_adaptor_s PF01217.20 EKE37667.1 - 7.7e-14 51.8 1.6 9.5e-14 51.5 1.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ectoine_synth PF06339.12 EKE37668.1 - 0.044 14.0 0.0 3.4 7.9 0.0 2.3 2 0 0 2 2 2 0 Ectoine synthase Utp11 PF03998.13 EKE37669.1 - 2.5e-16 60.3 24.2 1.3e-14 54.8 24.2 2.0 1 1 0 1 1 1 1 Utp11 protein LicD PF04991.13 EKE37669.1 - 0.32 11.1 11.0 0.44 10.7 11.0 1.2 1 0 0 1 1 1 0 LicD family Lipoprotein_20 PF13942.6 EKE37669.1 - 7.2 6.5 15.0 0.14 12.1 6.0 2.1 2 0 0 2 2 2 0 YfhG lipoprotein Sedlin_N PF04628.13 EKE37670.1 - 8.9e-30 103.5 2.1 1e-29 103.3 2.1 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EKE37670.1 - 5.4e-10 39.4 0.7 7.2e-10 38.9 0.7 1.3 1 1 0 1 1 1 1 Sybindin-like family zf-UBR PF02207.20 EKE37671.1 - 1.1e-06 28.7 12.3 3.2e-06 27.2 12.3 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) EF_TS PF00889.19 EKE37671.1 - 2.3 7.8 7.6 5.8 6.5 0.0 3.1 3 0 0 3 3 3 0 Elongation factor TS Gelsolin PF00626.22 EKE37672.1 - 2.4e-18 65.8 5.9 1.7e-05 24.6 0.3 4.7 5 0 0 5 5 5 3 Gelsolin repeat VHP PF02209.19 EKE37672.1 - 1.4e-13 50.6 0.4 1.4e-13 50.6 0.4 2.6 3 0 0 3 3 3 1 Villin headpiece domain PH PF00169.29 EKE37672.1 - 1.1e-09 38.7 17.6 4.6e-05 23.9 0.4 5.3 6 0 0 6 6 6 3 PH domain WD40 PF00400.32 EKE37672.1 - 1.7e-09 38.1 0.0 0.0009 20.0 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40_4 PF16300.5 EKE37672.1 - 3.2e-07 30.1 0.0 7.4e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 Type of WD40 repeat DUF1899 PF08953.11 EKE37672.1 - 1e-06 28.5 0.1 3e-06 27.0 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) ANAPC4_WD40 PF12894.7 EKE37672.1 - 0.0015 18.8 0.1 0.081 13.2 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain ANAPC4 PF12896.7 EKE37672.1 - 0.12 11.8 2.0 1.6 8.1 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 PH_6 PF15406.6 EKE37672.1 - 0.31 11.3 1.8 19 5.6 0.0 3.2 3 0 0 3 3 3 0 Pleckstrin homology domain HA2 PF04408.23 EKE37673.1 - 9.4e-24 83.8 4.9 2.3e-23 82.6 0.0 2.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EKE37673.1 - 8e-15 55.0 0.1 2.1e-14 53.7 0.1 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EKE37673.1 - 1.4e-14 54.4 0.3 1.4e-14 54.4 0.3 2.7 3 1 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EKE37673.1 - 1e-07 31.9 0.8 3e-07 30.4 0.8 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 EKE37673.1 - 4.3e-05 23.5 0.0 0.0001 22.3 0.0 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_22 PF13401.6 EKE37673.1 - 0.00031 21.0 0.3 0.0014 18.9 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EKE37673.1 - 0.00067 20.0 0.1 0.0018 18.7 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EKE37673.1 - 0.0046 16.7 3.1 0.011 15.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EKE37673.1 - 0.11 12.2 0.1 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_pol_N PF01194.17 EKE37674.1 - 2.2e-26 91.9 0.3 2.6e-26 91.7 0.3 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit DUF2951 PF11166.8 EKE37675.1 - 0.0033 17.6 2.6 0.0033 17.6 2.6 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF2951) DUF4665 PF15679.5 EKE37675.1 - 0.03 14.9 4.2 0.03 14.9 4.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4665) DUF16 PF01519.16 EKE37675.1 - 0.032 14.7 5.4 0.032 14.7 5.4 3.1 2 1 0 2 2 2 0 Protein of unknown function DUF16 Y_phosphatase3 PF13350.6 EKE37675.1 - 0.048 13.6 1.6 0.052 13.5 0.6 1.5 2 0 0 2 2 2 0 Tyrosine phosphatase family DUF4026 PF13218.6 EKE37675.1 - 0.061 12.3 4.1 0.053 12.5 2.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4026) ING PF12998.7 EKE37675.1 - 0.084 13.5 17.2 0.22 12.1 3.8 2.5 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Retrotrans_gag PF03732.17 EKE37675.1 - 0.11 12.8 0.6 0.31 11.3 0.1 1.9 2 0 0 2 2 2 0 Retrotransposon gag protein BLOC1_2 PF10046.9 EKE37675.1 - 0.2 12.0 19.7 6.2 7.2 4.4 3.9 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 COG5 PF10392.9 EKE37675.1 - 0.85 9.8 8.1 1.2 9.3 0.7 2.6 2 1 1 3 3 3 0 Golgi transport complex subunit 5 LCIB_C_CA PF18599.1 EKE37675.1 - 0.86 8.9 3.9 1.4 8.2 0.3 2.5 2 1 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases NPV_P10 PF05531.12 EKE37675.1 - 1.1 9.8 11.3 0.66 10.5 3.3 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Nsp1_C PF05064.13 EKE37675.1 - 1.6 8.6 11.1 0.06 13.1 1.9 2.6 2 2 0 2 2 2 0 Nsp1-like C-terminal region Laminin_II PF06009.12 EKE37675.1 - 1.7 8.7 13.6 1.9 8.5 4.8 2.2 2 0 0 2 2 2 0 Laminin Domain II CspB_prodomain PF18425.1 EKE37675.1 - 1.9 8.6 9.6 0.23 11.5 1.7 3.2 2 2 1 3 3 3 0 Csp protease B prodomain Baculo_PEP_C PF04513.12 EKE37675.1 - 2 8.4 6.5 1.2 9.2 2.4 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 EKE37675.1 - 2.3 8.4 17.1 1 9.6 5.1 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF948 PF06103.11 EKE37675.1 - 2.7 8.3 5.5 3.7 7.9 0.8 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Fzo_mitofusin PF04799.13 EKE37675.1 - 3.5 7.1 11.9 0.12 12.0 1.9 2.6 2 1 0 2 2 2 0 fzo-like conserved region DUF2203 PF09969.9 EKE37675.1 - 4.3 8.1 11.9 3.3 8.4 3.7 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) IBR PF01485.21 EKE37676.1 - 5.7e-13 48.9 24.1 5.4e-09 36.2 8.6 5.4 4 1 0 4 4 4 2 IBR domain, a half RING-finger domain UBA PF00627.31 EKE37676.1 - 7.9e-06 25.7 0.0 2.6e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 UBA/TS-N domain zf-RING_UBOX PF13445.6 EKE37676.1 - 0.00021 21.2 1.9 0.00021 21.2 1.9 5.1 4 1 0 4 4 4 1 RING-type zinc-finger C1_2 PF03107.16 EKE37676.1 - 0.00023 21.4 7.4 0.00023 21.4 7.4 5.4 4 2 2 6 6 6 1 C1 domain zf-C3HC4 PF00097.25 EKE37676.1 - 0.00046 20.0 4.3 0.00046 20.0 4.3 6.5 5 2 1 6 6 6 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE37676.1 - 0.00066 19.5 3.4 0.00066 19.5 3.4 6.1 5 2 0 6 6 6 2 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EKE37676.1 - 0.0018 18.4 3.5 0.0018 18.4 3.5 4.6 2 1 0 3 3 3 1 FYVE zinc finger zf-C3HC4_4 PF15227.6 EKE37676.1 - 0.012 15.8 4.6 0.012 15.8 4.6 5.5 4 2 0 4 4 4 0 zinc finger of C3HC4-type, RING CHD5 PF04420.14 EKE37676.1 - 1.3 8.9 4.6 1.1 9.1 0.7 2.4 2 0 0 2 2 2 0 CHD5-like protein DUF4598 PF15370.6 EKE37677.1 - 5.4e-10 39.7 4.5 7.9e-10 39.2 4.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4598) AP3D1 PF06375.11 EKE37677.1 - 0.019 15.2 4.4 0.021 15.1 4.4 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF1071 PF06378.11 EKE37677.1 - 0.07 12.7 0.0 0.11 12.0 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1071) Nop PF01798.18 EKE37678.1 - 1.2e-82 276.9 0.4 1.2e-82 276.9 0.4 1.8 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EKE37678.1 - 1.6e-18 66.8 0.7 1.6e-18 66.8 0.7 2.4 2 0 0 2 2 2 1 NOP5NT (NUC127) domain DUF1722 PF08349.11 EKE37678.1 - 0.02 15.2 1.5 0.18 12.1 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1722) PyrI PF01948.18 EKE37678.1 - 0.29 11.4 4.8 0.73 10.1 0.2 3.0 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, allosteric domain Ras PF00071.22 EKE37679.1 - 1.1e-52 177.9 1.0 1.4e-52 177.5 1.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37679.1 - 6.2e-33 113.6 0.2 1.2e-32 112.6 0.2 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37679.1 - 2.5e-22 79.1 0.2 3.4e-22 78.7 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE37679.1 - 4.3e-08 32.9 0.1 4.3e-07 29.7 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE37679.1 - 6.6e-06 26.1 0.1 0.045 13.7 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE37679.1 - 1.7e-05 24.8 0.0 2.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKE37679.1 - 0.00017 21.1 0.0 0.0006 19.4 0.0 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 EKE37679.1 - 0.0002 20.8 0.1 0.00033 20.1 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EKE37679.1 - 0.00025 20.8 0.7 0.034 13.9 0.7 2.4 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1_Xtn PF16897.5 EKE37679.1 - 0.00034 20.6 0.0 0.0006 19.8 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain SRPRB PF09439.10 EKE37679.1 - 0.00057 19.4 0.0 0.00091 18.7 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EKE37679.1 - 0.0024 18.2 0.1 0.0074 16.6 0.0 1.8 1 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EKE37679.1 - 0.003 17.1 0.1 0.0072 15.9 0.0 1.7 2 0 0 2 2 2 1 P-loop containing dynein motor region MeaB PF03308.16 EKE37679.1 - 0.0039 16.2 0.0 0.96 8.4 0.1 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 EKE37679.1 - 0.0039 17.6 0.2 0.015 15.7 0.0 1.9 1 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EKE37679.1 - 0.0045 17.4 0.0 0.0064 16.9 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 EKE37679.1 - 0.0047 16.4 0.0 0.021 14.2 0.0 1.9 2 0 0 2 2 2 1 Bacterial TniB protein AAA_5 PF07728.14 EKE37679.1 - 0.0053 16.7 0.0 0.013 15.5 0.0 1.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EKE37679.1 - 0.0083 15.9 0.4 0.076 12.7 0.0 2.4 2 1 1 3 3 3 1 AAA domain Septin PF00735.18 EKE37679.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 Septin NTPase_1 PF03266.15 EKE37679.1 - 0.014 15.3 0.2 0.031 14.2 0.1 1.5 1 1 0 1 1 1 0 NTPase Sigma54_activat PF00158.26 EKE37679.1 - 0.017 14.8 0.0 0.07 12.8 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain DBI_PRT PF02277.17 EKE37679.1 - 0.082 12.1 0.1 0.54 9.4 0.1 1.9 2 0 0 2 2 2 0 Phosphoribosyltransferase AAA_23 PF13476.6 EKE37679.1 - 0.091 13.3 3.3 0.14 12.6 3.3 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EKE37679.1 - 0.1 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RWD PF05773.22 EKE37680.1 - 8.6e-13 48.6 3.7 8.6e-13 48.6 3.7 1.8 2 1 0 2 2 2 1 RWD domain DFRP_C PF16543.5 EKE37680.1 - 0.0068 16.9 21.9 0.0068 16.9 21.9 2.4 2 1 0 2 2 2 1 DRG Family Regulatory Proteins, Tma46 UEV PF05743.13 EKE37680.1 - 0.095 12.6 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 UEV domain Adenylsucc_synt PF00709.21 EKE37680.1 - 1.8 7.4 8.0 1.6 7.5 6.8 1.5 1 1 1 2 2 2 0 Adenylosuccinate synthetase TPR_2 PF07719.17 EKE37681.1 - 6.1e-13 47.8 6.3 0.00015 21.6 0.1 5.0 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EKE37681.1 - 6e-11 41.7 7.4 0.00071 19.3 0.2 6.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EKE37681.1 - 2.1e-08 33.7 9.7 0.032 14.4 0.0 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EKE37681.1 - 8.7e-08 32.4 0.0 0.014 16.1 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EKE37681.1 - 8.8e-08 32.5 0.1 0.0062 17.0 0.0 3.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EKE37681.1 - 4.3e-06 27.3 0.0 0.0036 17.9 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EKE37681.1 - 3.7e-05 23.8 0.1 0.0051 17.1 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EKE37681.1 - 0.022 14.5 1.5 0.95 9.2 0.1 3.0 2 1 1 3 3 3 0 TPR repeat TPR_12 PF13424.6 EKE37681.1 - 0.027 14.8 1.0 12 6.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EKE37681.1 - 0.032 14.1 2.9 2.4 8.1 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.6 EKE37681.1 - 0.032 13.4 0.6 0.21 10.8 0.1 2.0 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EKE37681.1 - 0.079 13.0 0.1 35 4.7 0.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat KASH_CCD PF14662.6 EKE37681.1 - 0.28 11.0 7.9 0.66 9.8 7.9 1.6 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH IFT46_B_C PF12317.8 EKE37682.1 - 0.012 15.4 0.9 0.032 13.9 0.9 1.7 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal Q_salvage PF10343.9 EKE37684.1 - 7.6e-73 245.5 0.0 1.1e-72 245.0 0.0 1.2 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DUF1688 PF07958.11 EKE37684.1 - 0.051 12.3 0.1 3.3 6.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1688) DNA_ligase_aden PF01653.18 EKE37684.1 - 0.085 11.9 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent DNA ligase adenylation domain Glyco_hydro_14 PF01373.17 EKE37685.1 - 8.2e-102 341.2 3.2 1e-101 340.8 3.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 Glyco_hydro_35 PF01301.19 EKE37685.1 - 0.015 15.0 0.1 0.031 13.9 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 Allexi_40kDa PF05549.11 EKE37686.1 - 0.029 13.9 7.0 0.036 13.6 7.0 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein Usp PF00582.26 EKE37686.1 - 0.1 13.1 12.6 1.5 9.3 12.6 2.2 1 1 0 1 1 1 0 Universal stress protein family LMBR1 PF04791.16 EKE37686.1 - 3.2 6.6 15.0 3.8 6.3 15.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein SLC12 PF03522.15 EKE37686.1 - 7.2 5.5 22.1 9.1 5.2 22.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Cytomega_UL84 PF06284.11 EKE37687.1 - 0.0076 14.8 0.9 0.011 14.3 0.9 1.1 1 0 0 1 1 1 1 Cytomegalovirus UL84 protein PsaD PF02531.16 EKE37687.1 - 0.037 13.5 0.2 0.094 12.2 0.0 1.7 2 0 0 2 2 2 0 PsaD Atrophin-1 PF03154.15 EKE37687.1 - 1.9 6.7 8.6 2.5 6.3 8.6 1.1 1 0 0 1 1 1 0 Atrophin-1 family CDC45 PF02724.14 EKE37687.1 - 5.3 5.2 13.4 8.1 4.6 13.4 1.2 1 0 0 1 1 1 0 CDC45-like protein PTH2 PF01981.16 EKE37688.1 - 2.4e-44 150.3 0.2 3.3e-44 149.9 0.2 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Rsm22 PF09243.10 EKE37688.1 - 0.0026 17.1 0.0 0.003 16.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Rotavirus_VP1 PF12289.8 EKE37688.1 - 0.0064 15.6 0.1 0.008 15.3 0.1 1.1 1 0 0 1 1 1 1 Rotavirus VP1 C-terminal domain Phytochelatin PF05023.14 EKE37688.1 - 0.031 13.5 0.1 0.037 13.2 0.1 1.2 1 0 0 1 1 1 0 Phytochelatin synthase MukB_hinge PF16330.5 EKE37688.1 - 0.069 12.8 0.1 0.18 11.5 0.0 1.6 1 1 1 2 2 2 0 MukB hinge domain Pkinase_Tyr PF07714.17 EKE37689.1 - 4.8e-29 101.4 0.1 7.8e-29 100.7 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37689.1 - 3.8e-27 95.3 0.2 6.5e-27 94.5 0.2 1.5 1 1 0 1 1 1 1 Protein kinase domain FixG_C PF11614.8 EKE37689.1 - 0.0012 19.0 0.8 0.0024 18.1 0.8 1.5 1 0 0 1 1 1 1 IG-like fold at C-terminal of FixG, putative oxidoreductase NUDIX PF00293.28 EKE37690.1 - 1.3e-13 51.2 0.0 2.1e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain DCP2 PF05026.13 EKE37690.1 - 1.6e-08 34.7 2.4 2.2e-08 34.3 0.2 2.2 2 1 1 3 3 3 1 Dcp2, box A domain RhoGEF PF00621.20 EKE37691.1 - 4.7e-08 33.5 1.0 4.7e-08 33.5 1.0 4.2 4 0 0 4 4 4 1 RhoGEF domain DUF1298 PF06974.13 EKE37691.1 - 0.028 14.4 0.0 0.15 12.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1298) MbeD_MobD PF04899.12 EKE37691.1 - 0.85 9.8 7.2 0.43 10.7 0.7 3.6 3 0 0 3 3 3 0 MbeD/MobD like RhoGAP PF00620.27 EKE37692.1 - 3e-28 98.6 0.1 7.8e-28 97.2 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain IHABP4_N PF16174.5 EKE37692.1 - 0.053 14.1 2.5 0.088 13.4 2.5 1.3 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal 14-3-3 PF00244.20 EKE37693.1 - 3.5e-98 327.5 10.6 4e-98 327.4 10.6 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 EKE37693.1 - 0.049 13.6 0.1 0.21 11.6 0.0 2.1 2 0 0 2 2 2 0 Flagellar protein FlaF Hexokinase_1 PF00349.21 EKE37694.1 - 1.2e-09 38.4 0.1 1.2e-09 38.4 0.1 1.0 1 0 0 1 1 1 1 Hexokinase RhoGEF PF00621.20 EKE37695.1 - 1.7e-43 149.0 10.9 1.7e-43 149.0 10.9 2.4 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 EKE37695.1 - 0.0034 17.9 1.1 0.0087 16.6 1.1 1.7 1 0 0 1 1 1 1 PH domain PDZ_4 PF17816.1 EKE37695.1 - 0.075 13.4 1.9 0.1 13.0 0.2 2.1 2 1 0 2 2 2 0 PDZ domain ArgoMid PF16487.5 EKE37695.1 - 0.25 11.6 1.5 33 4.8 0.1 3.3 2 0 0 2 2 2 0 Mid domain of argonaute Ribosomal_S7 PF00177.21 EKE37695.1 - 1.1 8.9 8.5 0.4 10.3 0.5 3.4 2 2 1 3 3 3 0 Ribosomal protein S7p/S5e Med9 PF07544.13 EKE37697.1 - 0.06 13.4 0.6 0.06 13.4 0.6 2.4 3 1 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Bax1-I PF01027.20 EKE37698.1 - 4e-07 30.1 33.3 4.8e-07 29.8 33.3 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Ras PF00071.22 EKE37699.1 - 1.7e-47 161.0 0.3 2e-47 160.8 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37699.1 - 2.4e-30 105.2 0.5 3.9e-30 104.5 0.1 1.5 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37699.1 - 8.5e-11 41.6 0.1 1.1e-10 41.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE37699.1 - 1.6e-10 40.8 0.2 2.1e-09 37.2 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE37699.1 - 2.7e-09 37.1 0.0 4.8e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE37699.1 - 1.8e-07 30.8 0.1 2.2e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE37699.1 - 1.6e-06 28.1 0.2 0.00024 21.0 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 EKE37699.1 - 0.00078 19.2 0.4 0.0099 15.6 0.4 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EKE37699.1 - 0.0045 17.4 0.0 0.0095 16.3 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain DAP3 PF10236.9 EKE37699.1 - 0.0046 16.2 0.1 0.0091 15.2 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 Septin PF00735.18 EKE37699.1 - 0.0051 16.1 0.1 0.0076 15.6 0.1 1.3 1 0 0 1 1 1 1 Septin AAA_5 PF07728.14 EKE37699.1 - 0.0066 16.4 0.0 0.0093 16.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EKE37699.1 - 0.0089 16.3 0.0 0.014 15.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AIG1 PF04548.16 EKE37699.1 - 0.012 15.0 0.1 0.024 14.0 0.1 1.5 1 0 0 1 1 1 0 AIG1 family SRPRB PF09439.10 EKE37699.1 - 0.015 14.8 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EKE37699.1 - 0.018 14.8 0.2 0.55 10.0 0.2 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EKE37699.1 - 0.018 14.6 0.2 0.029 13.9 0.2 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 EKE37699.1 - 0.02 14.1 0.4 0.027 13.7 0.4 1.4 1 1 0 1 1 1 0 G-protein alpha subunit RNA_helicase PF00910.22 EKE37699.1 - 0.025 15.0 0.1 0.055 13.9 0.0 1.7 2 0 0 2 2 1 0 RNA helicase AAA_29 PF13555.6 EKE37699.1 - 0.028 14.2 0.0 0.07 12.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 EKE37699.1 - 0.03 13.8 0.1 0.78 9.2 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B MCM PF00493.23 EKE37699.1 - 0.034 13.2 0.0 0.048 12.7 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain NACHT PF05729.12 EKE37699.1 - 0.04 13.8 0.0 0.1 12.5 0.0 1.6 2 0 0 2 2 2 0 NACHT domain ATP_bind_1 PF03029.17 EKE37699.1 - 0.054 13.3 0.7 4.5 7.0 0.1 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 EKE37699.1 - 0.059 13.9 0.1 0.12 12.9 0.1 1.5 1 0 0 1 1 1 0 ABC transporter NTPase_1 PF03266.15 EKE37699.1 - 0.065 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 NTPase TniB PF05621.11 EKE37699.1 - 0.11 11.9 0.1 0.16 11.4 0.1 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Guanylate_kin PF00625.21 EKE37699.1 - 0.15 11.8 0.2 3 7.5 0.0 2.2 2 1 0 2 2 2 0 Guanylate kinase RasGEF PF00617.19 EKE37700.1 - 5.7e-23 82.0 1.8 1.4e-22 80.8 1.8 1.6 1 0 0 1 1 1 1 RasGEF domain Imm26 PF15428.6 EKE37701.1 - 0.26 11.5 5.4 0.3 11.3 2.0 2.6 1 1 2 3 3 3 0 Immunity protein 26 GA PF01468.17 EKE37701.1 - 1.9 8.8 9.7 24 5.3 0.2 3.6 3 1 0 3 3 3 0 GA module Beach PF02138.18 EKE37704.1 - 2.2e-113 378.3 0.0 5.6e-113 376.9 0.0 1.8 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EKE37704.1 - 5.3e-08 32.9 1.7 1.1e-07 31.9 0.0 2.4 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 EKE37704.1 - 1.8e-07 31.4 0.0 8e-07 29.3 0.0 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 EKE37704.1 - 0.00012 22.7 3.9 0.41 11.6 0.1 4.6 3 1 1 4 4 4 2 WD domain, G-beta repeat Vps16_C PF04840.12 EKE37704.1 - 0.00028 20.1 0.1 0.00074 18.7 0.1 1.7 1 0 0 1 1 1 1 Vps16, C-terminal region ANAPC4_WD40 PF12894.7 EKE37704.1 - 0.026 14.8 0.2 3.6 8.0 0.1 3.6 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain FAS_N PF17828.1 EKE37704.1 - 0.029 14.4 2.1 0.38 10.8 0.7 3.1 2 0 0 2 2 2 0 N-terminal domain in fatty acid synthase subunit beta DUF4800 PF16057.5 EKE37704.1 - 0.033 13.4 4.0 0.036 13.3 1.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4800) DUF573 PF04504.14 EKE37704.1 - 6.3 7.5 6.3 36 5.1 0.1 4.1 3 0 0 3 3 3 0 Protein of unknown function, DUF573 Histone PF00125.24 EKE37705.1 - 1e-40 139.1 4.1 1.4e-40 138.7 4.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EKE37705.1 - 3.1e-05 24.3 0.1 0.00015 22.0 0.0 1.9 2 0 0 2 2 2 1 CENP-S protein CENP-T_C PF15511.6 EKE37705.1 - 4.2e-05 23.6 0.7 7e-05 22.9 0.1 1.6 1 1 1 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EKE37705.1 - 0.016 15.5 0.1 0.032 14.5 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SKG6 PF08693.10 EKE37706.1 - 1.6e-05 24.2 6.0 1.6e-05 24.2 6.0 2.3 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Mid2 PF04478.12 EKE37706.1 - 0.00098 19.0 3.3 0.0022 17.9 3.3 1.6 1 1 0 1 1 1 1 Mid2 like cell wall stress sensor Rax2 PF12768.7 EKE37706.1 - 0.0013 18.2 0.1 0.0015 18.0 0.1 1.1 1 0 0 1 1 1 1 Cortical protein marker for cell polarity DUF2723 PF11028.8 EKE37706.1 - 0.0013 18.7 0.4 0.0018 18.2 0.4 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2723) Shisa PF13908.6 EKE37706.1 - 0.0014 18.9 0.2 0.0016 18.7 0.2 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 EKE37706.1 - 0.0024 18.7 1.3 1.3 9.9 1.2 2.1 1 1 1 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain OppC_N PF12911.7 EKE37706.1 - 0.0027 17.6 0.2 2.4 8.2 0.4 2.1 2 0 0 2 2 2 2 N-terminal TM domain of oligopeptide transport permease C DUF4064 PF13273.6 EKE37706.1 - 0.0049 17.1 1.5 0.0069 16.6 1.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) DUF997 PF06196.12 EKE37706.1 - 0.0069 16.4 0.9 0.12 12.3 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF997) Presenilin PF01080.17 EKE37706.1 - 0.014 14.1 1.3 0.016 14.0 1.3 1.0 1 0 0 1 1 1 0 Presenilin TMEM154 PF15102.6 EKE37706.1 - 0.028 14.3 0.9 0.035 14.0 0.2 1.5 1 1 1 2 2 2 0 TMEM154 protein family CYYR1 PF10873.8 EKE37706.1 - 0.04 14.4 0.6 0.047 14.2 0.6 1.1 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 OAD_gamma PF04277.13 EKE37706.1 - 0.047 14.3 0.8 0.71 10.5 0.9 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF2207 PF09972.9 EKE37706.1 - 0.055 12.2 0.1 0.067 12.0 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LRRC37AB_C PF14914.6 EKE37706.1 - 0.059 13.3 1.0 0.067 13.1 0.4 1.4 1 1 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF4514 PF14986.6 EKE37706.1 - 0.062 13.3 3.1 0.051 13.6 1.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4514) Orf78 PF06024.12 EKE37706.1 - 0.081 13.2 2.5 0.081 13.2 1.4 1.5 1 1 0 1 1 1 0 Orf78 (ac78) FeoB_associated PF12669.7 EKE37706.1 - 0.12 12.8 4.0 0.93 9.9 2.2 2.2 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Amnionless PF14828.6 EKE37706.1 - 0.14 10.9 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Amnionless GRP PF07172.11 EKE37706.1 - 0.16 12.6 0.1 10 6.9 0.0 2.0 2 0 0 2 2 2 0 Glycine rich protein family Sigma_reg_N PF13800.6 EKE37706.1 - 0.18 12.1 2.8 1.5 9.2 1.9 2.0 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Cytadhesin_P30 PF07271.11 EKE37706.1 - 0.28 10.7 0.0 0.28 10.7 0.0 1.0 1 0 0 1 1 1 0 Cytadhesin P30/P32 ODV-E18 PF10717.9 EKE37706.1 - 0.45 10.4 10.7 0.84 9.6 1.2 2.3 1 1 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DUF5385 PF17359.2 EKE37706.1 - 0.7 9.4 2.3 2.8 7.4 2.5 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5385) Pox_A14 PF05767.12 EKE37706.1 - 1.2 9.4 7.2 88 3.4 7.2 2.1 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 MLANA PF14991.6 EKE37706.1 - 1.4 9.2 4.8 6 7.2 2.4 2.1 1 1 1 2 2 2 0 Protein melan-A Synaptobrevin PF00957.21 EKE37706.1 - 1.9 8.3 5.0 0.51 10.2 1.3 2.0 1 1 1 2 2 2 0 Synaptobrevin DUF2613 PF11021.8 EKE37706.1 - 2.3 8.4 3.8 23 5.2 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2613) Orthoreo_P10 PF07204.11 EKE37706.1 - 2.7 8.0 6.3 0.46 10.5 0.5 2.0 1 1 1 2 2 2 0 Orthoreovirus membrane fusion protein p10 DUF347 PF03988.12 EKE37706.1 - 4.1 7.7 8.1 2 8.7 3.7 2.2 2 1 0 2 2 2 0 Repeat of Unknown Function (DUF347) Baculo_11_kDa PF06143.11 EKE37706.1 - 8.7 6.0 8.3 0.58 9.8 2.1 1.9 1 1 1 2 2 2 0 Baculovirus 11 kDa family Nucleoporin2 PF04096.14 EKE37707.1 - 1e-28 100.3 0.3 4.2e-28 98.3 0.3 2.0 1 1 0 1 1 1 1 Nucleoporin autopeptidase SUI1 PF01253.22 EKE37708.1 - 1.9e-17 63.5 0.0 2.5e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Mut7-C PF01927.16 EKE37708.1 - 0.033 14.3 0.0 0.038 14.1 0.0 1.1 1 0 0 1 1 1 0 Mut7-C RNAse domain Big_6 PF17936.1 EKE37708.1 - 0.08 13.2 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial Ig domain DUF2483 PF10656.9 EKE37709.1 - 0.0089 16.2 2.1 0.012 15.8 2.1 1.2 1 0 0 1 1 1 1 Hypothetical protein of unknown function (DUF2483) Shugoshin_N PF07558.11 EKE37710.1 - 0.0094 15.8 3.2 0.0094 15.8 3.2 2.2 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region HAUS5 PF14817.6 EKE37710.1 - 0.015 14.1 12.6 0.019 13.7 12.6 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 IML1 PF12257.8 EKE37710.1 - 2.2 7.3 11.4 0.05 12.7 0.8 2.1 1 1 1 2 2 2 0 Vacuolar membrane-associated protein Iml1 NAAA-beta PF15508.6 EKE37711.1 - 0.068 13.5 0.1 24 5.3 0.0 2.7 3 0 0 3 3 3 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase RNase_P_p30 PF01876.16 EKE37712.1 - 3.2e-32 111.8 0.4 3.5e-32 111.6 0.4 1.1 1 0 0 1 1 1 1 RNase P subunit p30 RE_MamI PF09567.10 EKE37712.1 - 0.038 13.6 0.0 0.094 12.3 0.0 1.6 2 0 0 2 2 2 0 MamI restriction endonuclease HMG_box PF00505.19 EKE37713.1 - 4.7e-20 71.8 7.7 4.7e-20 71.8 7.7 5.1 3 1 3 6 6 6 1 HMG (high mobility group) box LisH PF08513.11 EKE37713.1 - 7.3e-06 25.8 0.1 1.3e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 LisH zf-B_box PF00643.24 EKE37714.1 - 0.0072 16.5 4.4 0.0072 16.5 4.4 2.2 2 0 0 2 2 2 1 B-box zinc finger zf-UBR PF02207.20 EKE37714.1 - 0.15 12.2 17.2 0.13 12.4 14.8 2.3 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) KOG2701 PF09762.9 EKE37715.1 - 2.2e-39 135.5 0.0 2.2e-39 135.5 0.0 3.7 2 1 1 3 3 3 1 Coiled-coil domain-containing protein (DUF2037) CP12 PF02672.15 EKE37715.1 - 0.3 11.9 22.4 0.4 11.5 1.5 3.6 2 1 1 3 3 3 0 CP12 domain UPF0242 PF06785.11 EKE37715.1 - 2.4 8.2 61.4 0.21 11.6 31.9 3.0 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus RhoGEF PF00621.20 EKE37716.1 - 1.3e-31 110.2 14.4 1.3e-31 110.2 14.4 2.6 3 0 0 3 3 3 1 RhoGEF domain ArfGap PF01412.18 EKE37716.1 - 6.8e-14 51.9 0.0 2.6e-13 50.1 0.0 2.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf CH PF00307.31 EKE37716.1 - 6.2e-11 42.4 1.1 1.4e-10 41.3 0.1 2.3 2 0 0 2 2 2 1 Calponin homology (CH) domain PH PF00169.29 EKE37716.1 - 1.9e-08 34.8 0.1 0.00011 22.6 0.0 3.3 3 0 0 3 3 3 2 PH domain IQ PF00612.27 EKE37716.1 - 0.018 14.8 0.1 0.048 13.5 0.1 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif SMK-1 PF04802.15 EKE37718.1 - 0.018 14.9 3.8 0.83 9.5 0.2 2.2 2 0 0 2 2 2 0 Component of IIS longevity pathway SMK-1 SIL1 PF16782.5 EKE37718.1 - 0.027 13.7 1.0 0.038 13.2 0.2 1.6 2 0 0 2 2 2 0 Nucleotide exchange factor SIL1 Renin_r PF07850.14 EKE37718.1 - 0.048 14.3 0.7 0.087 13.4 0.7 1.5 1 0 0 1 1 1 0 Renin receptor-like protein BET PF17035.5 EKE37719.1 - 0.076 13.2 1.9 0.17 12.0 1.9 1.6 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation DUF4745 PF15923.5 EKE37719.1 - 0.082 12.9 0.0 0.67 9.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4745) PP2C PF00481.21 EKE37720.1 - 1.1e-35 123.5 0.6 1.1e-35 123.5 0.6 1.8 2 1 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE37720.1 - 6.3e-06 26.0 0.1 0.00045 19.9 0.1 2.8 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE37720.1 - 0.0014 18.6 0.1 0.028 14.3 0.1 2.4 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PHC2_SAM_assoc PF16616.5 EKE37720.1 - 0.043 14.6 0.2 0.09 13.6 0.2 1.6 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 MAGP PF05507.11 EKE37720.1 - 0.063 13.7 0.3 0.14 12.5 0.3 1.6 1 0 0 1 1 1 0 Microfibril-associated glycoprotein (MAGP) DHH PF01368.20 EKE37720.1 - 0.25 11.6 2.5 0.64 10.3 1.2 2.3 1 1 1 2 2 2 0 DHH family Prefoldin PF02996.17 EKE37721.1 - 1.4e-13 50.8 3.4 1.5e-13 50.7 2.3 1.6 1 1 1 2 2 2 1 Prefoldin subunit HTH_1 PF00126.27 EKE37721.1 - 0.014 15.3 0.2 0.024 14.6 0.2 1.3 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family ATP-synt_E PF05680.12 EKE37721.1 - 0.11 12.8 2.1 0.12 12.7 0.6 1.9 2 0 0 2 2 2 0 ATP synthase E chain DNA_pol3_beta_3 PF02768.15 EKE37721.1 - 0.14 12.0 1.3 0.18 11.6 0.1 1.7 2 0 0 2 2 2 0 DNA polymerase III beta subunit, C-terminal domain Gar1 PF04410.14 EKE37722.1 - 3.1e-18 66.0 5.5 5.9e-18 65.1 5.5 1.5 1 1 0 1 1 1 1 Gar1/Naf1 RNA binding region Peptidase_C98 PF15499.6 EKE37723.1 - 0.32 10.4 11.6 0.057 12.9 8.2 1.5 1 1 1 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase SPATA3 PF15662.5 EKE37723.1 - 4 8.0 8.1 5.5 7.6 8.1 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family TMEM144 PF07857.12 EKE37725.1 - 2.7e-93 312.6 10.8 2.6e-92 309.3 10.8 1.9 1 1 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 EKE37725.1 - 7.3e-10 38.6 22.0 1.8e-07 30.8 3.9 2.9 2 1 0 3 3 3 2 Sugar transport protein Ureide_permease PF07168.11 EKE37725.1 - 6.2e-06 25.2 0.0 0.00062 18.6 0.0 2.2 2 0 0 2 2 2 2 Ureide permease ALG3 PF05208.13 EKE37725.1 - 0.02 14.3 0.6 0.038 13.4 0.6 1.4 1 0 0 1 1 1 0 ALG3 protein Shisa PF13908.6 EKE37725.1 - 0.04 14.2 0.1 0.04 14.2 0.1 2.5 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator TRAP_alpha PF03896.16 EKE37725.1 - 0.12 11.5 1.4 0.19 10.9 1.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Tim54 PF11711.8 EKE37725.1 - 0.14 10.9 0.9 0.19 10.5 0.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FUSC-like PF12805.7 EKE37725.1 - 0.27 10.3 0.9 0.56 9.2 0.9 1.4 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS GET2 PF08690.10 EKE37725.1 - 2.7 7.6 5.5 0.88 9.2 2.5 1.6 2 0 0 2 2 2 0 GET complex subunit GET2 Pkinase_Tyr PF07714.17 EKE37727.1 - 1.4e-48 165.4 0.0 3.1e-48 164.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37727.1 - 2.1e-38 132.2 1.7 3e-38 131.7 0.0 2.1 3 0 0 3 3 3 1 Protein kinase domain COMM_domain PF07258.14 EKE37727.1 - 0.34 11.1 2.8 17 5.6 0.1 3.0 3 0 0 3 3 3 0 COMM domain Baculo_11_kDa PF06143.11 EKE37727.1 - 0.47 10.1 3.6 0.46 10.1 1.6 2.0 2 0 0 2 2 2 0 Baculovirus 11 kDa family PARG_cat PF05028.14 EKE37729.1 - 4.8e-73 246.4 0.0 5.9e-73 246.1 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) SUR7 PF06687.12 EKE37730.1 - 0.00016 21.4 1.1 0.00017 21.3 1.1 1.1 1 0 0 1 1 1 1 SUR7/PalI family Glycophorin_A PF01102.18 EKE37730.1 - 0.079 13.2 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Glycophorin A DUF2207 PF09972.9 EKE37730.1 - 0.088 11.6 0.2 0.098 11.4 0.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) zf-LITAF-like PF10601.9 EKE37730.1 - 0.72 10.2 2.8 0.75 10.1 0.1 2.1 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain CDV3 PF15359.6 EKE37732.1 - 0.089 13.3 0.8 0.16 12.4 0.8 1.3 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 Ribosomal_L30 PF00327.20 EKE37732.1 - 0.27 11.2 1.1 7.7 6.5 0.0 3.5 4 0 0 4 4 4 0 Ribosomal protein L30p/L7e SATase_N PF06426.14 EKE37733.1 - 0.38 11.2 1.5 1.6 9.1 1.5 2.1 1 0 0 1 1 1 0 Serine acetyltransferase, N-terminal HALZ PF02183.18 EKE37733.1 - 6 7.2 19.6 1.6 9.0 4.3 4.2 4 0 0 4 4 4 0 Homeobox associated leucine zipper Erythrovirus_X PF06795.11 EKE37734.1 - 0.035 14.4 1.6 2 8.8 0.1 2.8 2 1 0 3 3 3 0 Erythrovirus X protein GlcV_C_terminal PF17847.1 EKE37734.1 - 0.12 12.9 0.0 0.2 12.2 0.0 1.3 1 0 0 1 1 1 0 Glucose ABC transporter C-terminal domain Cob_adeno_trans PF01923.18 EKE37735.1 - 0.009 16.2 2.5 1.3 9.1 0.1 3.1 2 1 0 3 3 3 2 Cobalamin adenosyltransferase Pkinase_Tyr PF07714.17 EKE37736.1 - 1.1e-46 159.2 0.0 1.3e-46 158.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37736.1 - 2.5e-44 151.6 0.0 3.1e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE37736.1 - 3e-09 36.2 0.0 4.4e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE37736.1 - 0.0081 15.5 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ras PF00071.22 EKE37737.1 - 9e-47 158.7 2.3 1.3e-46 158.2 2.3 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37737.1 - 4.8e-30 104.2 0.8 8.7e-30 103.4 0.8 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37737.1 - 9.1e-12 44.8 0.1 1.4e-11 44.2 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE37737.1 - 4.5e-07 29.5 0.2 5.8e-07 29.1 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EKE37737.1 - 1.5e-06 27.7 0.2 1.5e-06 27.7 0.2 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EKE37737.1 - 1.1e-05 25.5 0.0 1.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE37737.1 - 0.00062 19.4 0.8 0.038 13.5 0.8 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 EKE37737.1 - 0.018 14.5 0.0 0.031 13.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein DUF1993 PF09351.10 EKE37737.1 - 0.11 12.7 0.1 2 8.6 0.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF1993) PqiA PF04403.13 EKE37738.1 - 2.3e-12 47.0 3.3 2.3e-12 47.0 3.3 1.7 2 0 0 2 2 2 1 Paraquat-inducible protein A V_ATPase_I PF01496.19 EKE37738.1 - 0.0021 16.1 1.6 0.0029 15.6 1.6 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF4834 PF16118.5 EKE37738.1 - 0.024 15.6 0.1 0.024 15.6 0.1 2.4 3 0 0 3 3 2 0 Domain of unknown function (DUF4834) MAP17 PF15807.5 EKE37738.1 - 0.035 14.4 3.9 0.054 13.7 3.9 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF1449 PF07290.11 EKE37738.1 - 0.043 13.5 3.5 0.44 10.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1449) Nucleoside_tran PF01733.18 EKE37738.1 - 0.044 13.2 3.9 0.31 10.4 0.2 2.3 2 0 0 2 2 2 0 Nucleoside transporter Prolamin_like PF05617.11 EKE37738.1 - 0.05 13.8 1.0 0.4 10.9 0.1 2.7 2 1 0 2 2 2 0 Prolamin-like Zip PF02535.22 EKE37738.1 - 1.6 7.9 7.7 0.026 13.8 0.9 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter DUF913 PF06025.12 EKE37738.1 - 1.6 7.6 6.5 2.2 7.2 6.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SID-1_RNA_chan PF13965.6 EKE37738.1 - 2 6.7 8.1 0.06 11.8 0.8 1.8 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF4820 PF16091.5 EKE37738.1 - 2.3 7.6 8.6 3.1 7.1 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RRN3 PF05327.11 EKE37738.1 - 4.9 5.6 8.6 6 5.3 8.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PqiA PF04403.13 EKE37739.1 - 8.2e-08 32.2 11.8 8.3e-08 32.2 7.7 2.3 2 0 0 2 2 2 1 Paraquat-inducible protein A Rer1 PF03248.13 EKE37739.1 - 0.005 16.6 0.0 0.014 15.1 0.0 1.8 1 0 0 1 1 1 1 Rer1 family CD20 PF04103.15 EKE37739.1 - 0.0079 16.3 0.0 0.025 14.6 0.0 1.9 1 0 0 1 1 1 1 CD20-like family DUF4834 PF16118.5 EKE37739.1 - 1.2 10.2 3.6 1.2 10.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PYC_OADA PF02436.18 EKE37740.1 - 4.9e-56 189.6 0.0 9.4e-56 188.7 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Carboxyl_trans PF01039.22 EKE37740.1 - 8.1e-28 97.3 0.8 2e-27 96.0 0.4 1.7 2 0 0 2 2 2 1 Carboxyl transferase domain HMGL-like PF00682.19 EKE37740.1 - 2.1e-25 89.8 0.0 3.4e-25 89.1 0.0 1.3 1 0 0 1 1 1 1 HMGL-like ACCA PF03255.14 EKE37740.1 - 4.4e-24 85.0 0.0 1e-23 83.8 0.0 1.6 1 0 0 1 1 1 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Biotin_lipoyl PF00364.22 EKE37740.1 - 7.4e-15 54.5 2.6 7.4e-15 54.5 2.6 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EKE37740.1 - 2.5e-05 24.0 0.2 0.061 13.2 0.0 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like RnfC_N PF13375.6 EKE37740.1 - 0.0059 16.5 0.3 0.014 15.4 0.3 1.6 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain HlyD_D23 PF16576.5 EKE37740.1 - 0.11 11.7 0.1 1.4 8.0 0.0 2.3 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 EKE37740.1 - 0.19 11.6 0.4 0.5 10.3 0.4 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein DUF3437 PF11919.8 EKE37741.1 - 1.3e-08 34.6 0.1 4.1e-08 33.0 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) AAA_lid_7 PF17867.1 EKE37741.1 - 0.0083 16.3 0.7 0.31 11.2 0.1 3.2 3 0 0 3 3 3 1 Midasin AAA lid domain VPS9 PF02204.18 EKE37742.1 - 3e-19 69.1 0.1 6.9e-19 68.0 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Rtt106 PF08512.12 EKE37743.1 - 6.3e-17 61.8 0.8 3.2e-16 59.5 0.3 2.2 2 0 0 2 2 2 1 Histone chaperone Rttp106-like SSrecog PF03531.14 EKE37743.1 - 5.4e-13 48.6 0.8 1.2e-11 44.3 0.0 3.2 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) NOA36 PF06524.12 EKE37743.1 - 6.5 6.0 10.3 0.11 11.8 3.7 1.5 2 0 0 2 2 2 0 NOA36 protein ExbD PF02472.16 EKE37744.1 - 0.012 15.8 4.2 0.018 15.2 4.2 1.3 1 1 0 1 1 1 0 Biopolymer transport protein ExbD/TolR O-antigen_lig PF13425.6 EKE37744.1 - 0.39 9.4 2.8 0.46 9.2 2.8 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein FOXP-CC PF16159.5 EKE37744.1 - 4 8.1 5.9 0.84 10.3 1.8 1.9 1 1 2 3 3 3 0 FOXP coiled-coil domain DUF2852 PF11014.8 EKE37745.1 - 0.12 12.5 0.2 0.17 12.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Bowman-Birk_leg PF00228.20 EKE37745.1 - 0.48 10.9 6.2 3.2 8.2 0.2 2.9 3 0 0 3 3 3 0 Bowman-Birk serine protease inhibitor family Pkinase PF00069.25 EKE37748.1 - 4.5e-48 163.9 0.0 1.5e-47 162.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37748.1 - 5e-17 62.0 0.0 1.1e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EKE37748.1 - 0.0048 16.5 0.0 0.013 15.1 0.0 1.7 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EKE37748.1 - 0.0086 16.0 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EKE37748.1 - 0.072 11.9 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase RhoGEF PF00621.20 EKE37749.1 - 3.8e-43 147.9 7.2 3.8e-43 147.9 7.2 3.0 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 EKE37749.1 - 0.00074 20.0 2.0 0.00091 19.7 0.3 2.1 2 0 0 2 2 2 1 PH domain Pkinase_Tyr PF07714.17 EKE37750.1 - 8.6e-53 179.3 0.0 1.3e-52 178.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37750.1 - 1.7e-44 152.2 0.2 3.9e-44 151.0 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE37750.1 - 9.5e-05 21.3 0.0 0.00018 20.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE37750.1 - 0.026 13.9 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ndc80_HEC PF03801.13 EKE37750.1 - 0.07 12.8 1.9 0.79 9.3 0.0 2.5 2 0 0 2 2 2 0 HEC/Ndc80p family FTA2 PF13095.6 EKE37750.1 - 0.091 12.4 0.0 5.4 6.6 0.0 2.4 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 ABC1 PF03109.16 EKE37750.1 - 0.095 12.9 0.0 0.43 10.7 0.0 2.0 1 1 0 1 1 1 0 ABC1 family RNA_pol_Rpb1_2 PF00623.20 EKE37750.1 - 0.11 12.8 0.3 1.1 9.5 0.0 2.5 3 0 0 3 3 3 0 RNA polymerase Rpb1, domain 2 mRNA_cap_enzyme PF01331.19 EKE37752.1 - 2.3e-24 86.3 2.0 2.3e-24 86.3 2.0 2.2 2 1 0 2 2 2 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EKE37752.1 - 1.1e-11 45.3 2.6 1.7e-11 44.7 0.2 2.5 2 1 0 2 2 2 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EKE37752.1 - 1e-08 35.1 0.4 0.0049 16.5 0.0 2.6 1 1 1 2 2 2 2 ATP dependent DNA ligase domain mRNA_triPase PF02940.15 EKE37752.1 - 6.8e-05 22.7 7.4 0.00039 20.2 7.4 2.2 1 1 0 1 1 1 1 mRNA capping enzyme, beta chain PAC4 PF16093.5 EKE37753.1 - 2.1e-12 47.1 0.1 2.6e-12 46.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 MCPVI PF02993.14 EKE37754.1 - 0.057 13.2 0.1 0.057 13.2 0.1 3.3 2 1 1 3 3 3 0 Minor capsid protein VI Goodbye PF17109.5 EKE37754.1 - 0.52 10.8 5.3 0.63 10.5 0.8 2.9 2 1 0 2 2 2 0 fungal STAND N-terminal Goodbye domain DASH_Dad2 PF08654.10 EKE37754.1 - 1.2 9.6 4.7 0.43 11.0 0.6 2.4 3 0 0 3 3 3 0 DASH complex subunit Dad2 DUF2277 PF10041.9 EKE37754.1 - 1.6 9.2 4.8 0.58 10.5 0.2 2.7 3 1 1 4 4 4 0 Uncharacterized conserved protein (DUF2277) DUF1722 PF08349.11 EKE37755.1 - 0.45 10.8 7.2 1.7 8.9 0.3 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1722) Alpha_L_fucos PF01120.17 EKE37755.1 - 1.6 8.1 6.5 0.21 11.0 1.1 2.0 2 0 0 2 2 2 0 Alpha-L-fucosidase DUF3837 PF12939.7 EKE37755.1 - 3.3 8.2 16.7 0.46 10.9 0.7 5.0 3 1 2 5 5 5 0 Domain of unknown function (DUF3837) Profilin PF00235.19 EKE37756.1 - 5.7e-30 104.2 1.1 6.4e-30 104.0 1.1 1.0 1 0 0 1 1 1 1 Profilin Glyco_hydro_18 PF00704.28 EKE37757.1 - 4.7e-89 299.2 13.2 5.6e-89 298.9 13.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF4614 PF15391.6 EKE37757.1 - 0.27 11.2 4.9 0.54 10.2 4.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Phenyl_P_gamma PF09662.10 EKE37758.1 - 0.11 12.7 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) TMEM174 PF15029.6 EKE37759.1 - 0.056 13.2 0.4 0.099 12.4 0.2 1.4 1 1 0 1 1 1 0 Transmembrane protein 174 DBR1 PF05011.13 EKE37759.1 - 0.072 13.5 6.9 0.14 12.6 3.1 2.0 1 1 1 2 2 2 0 Lariat debranching enzyme, C-terminal domain SPT16 PF08644.11 EKE37760.1 - 1.9e-28 99.6 0.5 1.9e-28 99.6 0.5 3.0 2 1 1 3 3 3 1 FACT complex subunit (SPT16/CDC68) Rtt106 PF08512.12 EKE37760.1 - 2e-15 57.0 1.3 3.7e-15 56.1 0.2 2.1 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Tox-REase-2 PF15646.6 EKE37760.1 - 0.039 14.1 1.9 0.73 10.0 0.4 3.0 1 1 1 2 2 2 0 Restriction endonuclease fold toxin 2 YL1 PF05764.13 EKE37760.1 - 0.15 12.1 30.6 2.5 8.2 16.2 3.2 3 0 0 3 3 3 0 YL1 nuclear protein Astro_capsid_p PF12226.8 EKE37760.1 - 1.4 8.0 14.9 12 4.9 0.1 2.6 2 0 0 2 2 2 0 Turkey astrovirus capsid protein HD PF01966.22 EKE37761.1 - 9.6e-09 35.5 0.0 1.3e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 HD domain Autophagy_act_C PF03987.15 EKE37761.1 - 0.0024 18.4 0.0 0.0049 17.4 0.0 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain DUF3447 PF11929.8 EKE37761.1 - 0.49 10.4 4.3 0.44 10.5 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) Ras PF00071.22 EKE37762.1 - 2.6e-21 75.9 0.0 3.3e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 EKE37762.1 - 0.028 14.3 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase PNTB PF02233.16 EKE37763.1 - 1.5e-66 225.3 4.3 1.6e-66 225.1 4.3 1.0 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit EHD_N PF16880.5 EKE37764.1 - 4.3e-11 42.5 0.7 7e-11 41.8 0.7 1.4 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 EKE37764.1 - 6.1e-08 32.9 0.0 6.9e-07 29.5 0.0 2.1 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EKE37764.1 - 0.00027 21.0 0.0 0.00088 19.3 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EKE37764.1 - 0.058 13.6 0.0 0.084 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EKE37764.1 - 0.24 10.4 0.0 0.31 10.1 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein Peptidase_S74 PF13884.6 EKE37765.1 - 1.8e-13 50.6 0.0 5.2e-13 49.1 0.0 1.9 2 0 0 2 2 2 1 Chaperone of endosialidase TFIIA PF03153.13 EKE37765.1 - 0.14 12.1 9.9 0.19 11.7 9.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Wzy_C PF04932.15 EKE37765.1 - 1.4 8.5 9.9 0.018 14.7 2.4 1.7 2 0 0 2 2 2 0 O-Antigen ligase RasGAP PF00616.19 EKE37766.1 - 1.6e-26 93.4 0.6 8.1e-26 91.0 0.6 2.1 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase SH3_1 PF00018.28 EKE37767.1 - 7.5e-14 51.1 0.1 1.4e-13 50.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EKE37767.1 - 3.1e-13 49.2 0.0 7.5e-13 47.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EKE37767.1 - 3.7e-11 42.7 0.0 6.4e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain PhoU_div PF01865.16 EKE37768.1 - 0.079 12.3 0.1 0.19 11.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF47 ARID PF01388.21 EKE37769.1 - 0.31 11.8 2.3 2.2 9.0 0.3 3.4 2 1 1 3 3 3 0 ARID/BRIGHT DNA binding domain Vps51 PF08700.11 EKE37769.1 - 0.83 9.8 9.4 0.26 11.4 1.2 3.7 4 0 0 4 4 4 0 Vps51/Vps67 DnaJ PF00226.31 EKE37770.1 - 7.6e-19 67.6 0.8 1.2e-18 67.0 0.8 1.3 1 0 0 1 1 1 1 DnaJ domain Metallophos PF00149.28 EKE37771.1 - 3.4e-11 44.0 0.2 5.7e-11 43.3 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Piwi PF02171.17 EKE37772.1 - 1.1e-51 175.9 3.3 1.7e-51 175.3 3.3 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 EKE37772.1 - 7.9e-23 80.8 1.3 1.8e-22 79.6 1.3 1.6 1 0 0 1 1 1 1 PAZ domain GPAT_N PF14829.6 EKE37774.1 - 0.0063 16.5 0.1 0.0099 15.8 0.1 1.3 1 0 0 1 1 1 1 Glycerol-3-phosphate acyltransferase N-terminal Bactofilin PF04519.13 EKE37775.1 - 0.046 14.0 0.0 0.06 13.6 0.0 1.2 1 0 0 1 1 1 0 Polymer-forming cytoskeletal Ndc80_HEC PF03801.13 EKE37776.1 - 1.3e-10 41.1 0.3 1.3e-10 41.1 0.3 2.7 2 1 0 2 2 2 1 HEC/Ndc80p family Myb_DNA-binding PF00249.31 EKE37777.1 - 1e-10 41.6 0.6 1.4e-10 41.2 0.6 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE37777.1 - 0.016 15.4 0.1 0.038 14.2 0.1 1.7 1 1 0 1 1 1 0 Myb-like DNA-binding domain RINT1_TIP1 PF04437.13 EKE37777.1 - 0.023 13.6 1.7 0.026 13.4 1.7 1.0 1 0 0 1 1 1 0 RINT-1 / TIP-1 family Myb_DNA-bind_7 PF15963.5 EKE37777.1 - 0.038 13.9 0.2 0.06 13.2 0.2 1.4 1 0 0 1 1 1 0 Myb DNA-binding like IPK PF03770.16 EKE37777.1 - 0.11 12.4 1.7 0.14 12.0 1.7 1.1 1 0 0 1 1 1 0 Inositol polyphosphate kinase RRM_1 PF00076.22 EKE37778.1 - 4.3e-13 48.9 0.0 5.1e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 EKE37778.1 - 0.00025 20.9 0.0 0.00028 20.8 0.0 1.2 1 0 0 1 1 1 1 RL domain RRM_occluded PF16842.5 EKE37778.1 - 0.0027 17.5 0.0 0.0039 17.0 0.0 1.2 1 0 0 1 1 1 1 Occluded RNA-recognition motif SET_assoc PF11767.8 EKE37778.1 - 0.0028 17.2 0.0 0.0049 16.5 0.0 1.4 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated RRM_3 PF08777.11 EKE37778.1 - 0.01 15.9 0.0 0.018 15.1 0.0 1.4 1 1 0 1 1 1 0 RNA binding motif Limkain-b1 PF11608.8 EKE37778.1 - 0.069 13.2 0.0 0.096 12.8 0.0 1.2 1 0 0 1 1 1 0 Limkain b1 Sua5_yciO_yrdC PF01300.18 EKE37778.1 - 0.13 11.7 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 Telomere recombination HBB PF06777.11 EKE37779.1 - 0.017 14.8 1.7 2.1 8.0 0.2 2.5 2 1 0 2 2 2 0 Helical and beta-bridge domain DUF1043 PF06295.12 EKE37779.1 - 0.6 10.1 4.9 1.7 8.7 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) ComC PF03047.14 EKE37779.1 - 9.7 6.1 7.0 0.66 9.8 1.2 2.2 2 0 0 2 2 2 0 COMC family RabGAP-TBC PF00566.18 EKE37780.1 - 6.8e-30 104.3 0.6 9.2e-30 103.9 0.6 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain FMN_red PF03358.15 EKE37781.1 - 4.1e-25 88.3 0.0 4.9e-25 88.1 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EKE37781.1 - 1.1e-06 28.5 0.0 1.6e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Pkinase PF00069.25 EKE37782.1 - 6.2e-33 114.3 0.4 1.2e-32 113.4 0.4 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37782.1 - 2.8e-30 105.5 0.1 4.2e-30 104.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37782.1 - 5.6e-06 25.4 0.0 1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase CEL_III_C PF18054.1 EKE37782.1 - 0.053 13.6 0.1 0.14 12.2 0.1 1.7 1 0 0 1 1 1 0 CEL-III C-terminal XH PF03469.14 EKE37782.1 - 0.15 12.0 0.1 0.34 10.8 0.1 1.5 1 0 0 1 1 1 0 XH domain FTA2 PF13095.6 EKE37782.1 - 0.21 11.2 0.8 18 4.9 0.1 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Insulin_TMD PF17870.1 EKE37782.1 - 1.2 9.3 4.7 2.9 8.1 4.7 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment CTC1 PF15489.6 EKE37784.1 - 0.12 9.8 0.1 0.15 9.6 0.1 1.0 1 0 0 1 1 1 0 CST, telomere maintenance, complex subunit CTC1 Pex14_N PF04695.13 EKE37784.1 - 1.5 9.5 7.0 1.8 9.2 7.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ANAPC4_WD40 PF12894.7 EKE37785.1 - 6.5e-06 26.4 1.3 0.68 10.3 0.1 3.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain DUF5074 PF16819.5 EKE37785.1 - 0.0078 16.2 0.4 0.089 12.8 0.0 2.7 2 1 0 3 3 3 1 Domain of unknown function (DUF5074) Sec1 PF00995.23 EKE37786.1 - 7.7e-44 150.9 8.0 9.5e-44 150.6 8.0 1.1 1 0 0 1 1 1 1 Sec1 family Oxysterol_BP PF01237.18 EKE37786.1 - 0.02 13.7 0.5 0.031 13.1 0.5 1.2 1 0 0 1 1 1 0 Oxysterol-binding protein PhoLip_ATPase_C PF16212.5 EKE37787.1 - 1.4e-52 179.0 25.4 1.4e-52 179.0 25.4 2.4 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EKE37787.1 - 1.6e-24 85.4 2.2 6.6e-24 83.4 2.2 2.1 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EKE37787.1 - 3.6e-12 46.2 0.0 3.6e-12 46.2 0.0 2.1 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EKE37787.1 - 2.2e-10 41.2 0.1 1.5e-09 38.5 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EKE37787.1 - 9.9e-09 35.2 0.3 4.8e-08 33.0 0.1 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_6 PF13344.6 EKE37787.1 - 0.017 15.2 0.1 0.076 13.1 0.1 2.1 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF2344 PF10105.9 EKE37788.1 - 0.015 15.2 0.0 0.02 14.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) RRM_1 PF00076.22 EKE37789.1 - 5.4e-12 45.4 0.0 1.3e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PDGF_N PF04692.13 EKE37789.1 - 1.5 9.6 15.8 0.81 10.5 1.8 4.4 3 1 2 5 5 5 0 Platelet-derived growth factor, N terminal region His_Phos_1 PF00300.22 EKE37791.1 - 1e-21 77.5 0.0 1.6e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) ZnuA PF01297.17 EKE37791.1 - 0.19 11.1 1.8 0.24 10.7 0.1 2.0 3 1 0 3 3 3 0 Zinc-uptake complex component A periplasmic BEX PF04538.12 EKE37791.1 - 1.2 9.7 4.3 0.25 11.9 0.4 1.8 2 0 0 2 2 2 0 Brain expressed X-linked like family ubiquitin PF00240.23 EKE37792.1 - 5.4e-33 112.6 0.4 6e-33 112.4 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKE37792.1 - 2.1e-17 62.7 0.4 2.3e-17 62.6 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EKE37792.1 - 2.5e-05 24.6 0.1 0.00011 22.6 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EKE37792.1 - 0.00046 20.5 0.1 0.00052 20.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EKE37792.1 - 0.0034 17.3 0.0 0.0037 17.2 0.0 1.2 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EKE37792.1 - 0.0034 17.5 0.1 0.0075 16.4 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EKE37792.1 - 0.0071 16.4 0.6 3.4 7.8 0.0 2.0 1 1 1 2 2 2 2 Ubiquitin-like domain DUF2870 PF11069.8 EKE37792.1 - 0.11 12.9 0.2 0.64 10.4 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2870) ALMT PF11744.8 EKE37793.1 - 0.032 13.1 10.9 0.066 12.0 10.9 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec23_trunk PF04811.15 EKE37794.1 - 6.4e-52 176.5 0.3 1.1e-51 175.8 0.3 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EKE37794.1 - 1.6e-20 72.8 0.1 4.1e-20 71.5 0.1 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EKE37794.1 - 1.3e-17 64.3 0.1 2.2e-16 60.4 0.0 2.6 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EKE37794.1 - 3e-06 27.0 0.0 7.7e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat zf-Sec23_Sec24 PF04810.15 EKE37794.1 - 0.00014 21.8 9.3 0.00044 20.2 9.3 1.9 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger DSPc PF00782.20 EKE37795.1 - 6.8e-30 103.6 0.1 9.5e-30 103.1 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EKE37795.1 - 0.00072 19.8 0.3 0.0021 18.4 0.0 1.9 3 0 0 3 3 3 1 Rit1 DUSP-like domain CDKN3 PF05706.12 EKE37795.1 - 0.0066 16.1 0.0 0.009 15.7 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 EKE37795.1 - 0.035 13.7 0.0 0.047 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EKE37795.1 - 0.038 13.9 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family CorA PF01544.18 EKE37796.1 - 1.3e-20 74.0 8.9 1.3e-20 74.0 8.9 2.5 2 1 1 3 3 3 1 CorA-like Mg2+ transporter protein Tox-HNH-HHH PF15637.6 EKE37796.1 - 0.018 15.2 0.5 0.057 13.6 0.5 1.9 1 0 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif DUF4768 PF15989.5 EKE37796.1 - 9 6.3 7.6 2.1 8.3 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4768) Hexokinase_2 PF03727.16 EKE37797.1 - 1.8e-44 152.0 0.0 3.2e-44 151.2 0.0 1.4 1 1 0 1 1 1 1 Hexokinase SOBP PF15279.6 EKE37798.1 - 0.57 10.7 15.0 0.81 10.2 15.0 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein zf-C3HC4_3 PF13920.6 EKE37801.1 - 8.1e-09 35.2 8.4 1.3e-08 34.5 8.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE37801.1 - 1.8e-08 34.1 11.1 1.8e-08 34.1 11.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE37801.1 - 2.3e-08 34.2 12.2 4.6e-08 33.3 12.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EKE37801.1 - 3.2e-08 33.5 5.9 3.2e-08 33.5 5.9 2.5 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EKE37801.1 - 7.4e-08 32.1 12.2 7.4e-08 32.1 12.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EKE37801.1 - 8.3e-06 25.9 9.7 1.5e-05 25.0 9.1 1.8 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EKE37801.1 - 4.3e-05 23.7 9.7 0.00011 22.4 9.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EKE37801.1 - 0.00072 19.5 15.5 0.0024 17.8 13.5 2.5 2 1 1 3 3 3 1 zinc-RING finger domain WW PF00397.26 EKE37801.1 - 0.0066 16.5 0.9 0.016 15.3 0.3 2.0 2 0 0 2 2 2 1 WW domain Prok-RING_4 PF14447.6 EKE37801.1 - 0.042 13.7 14.2 0.48 10.3 14.7 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-ribbon_3 PF13248.6 EKE37801.1 - 0.13 11.7 0.3 0.13 11.7 0.3 3.2 3 0 0 3 3 3 0 zinc-ribbon domain zf-ANAPC11 PF12861.7 EKE37801.1 - 0.15 12.1 8.4 0.58 10.2 8.0 2.1 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger RE_AspBHI_N PF18062.1 EKE37801.1 - 0.21 11.1 0.9 7.9 6.0 0.0 2.2 1 1 1 2 2 2 0 Restriction endonuclease AspBHI N-terminal zinc-ribbons_6 PF07191.12 EKE37801.1 - 0.8 9.7 7.0 1.7 8.7 7.0 1.5 1 0 0 1 1 1 0 zinc-ribbons zf-RING_4 PF14570.6 EKE37801.1 - 1.2 9.0 12.3 0.31 10.8 6.2 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DZR PF12773.7 EKE37801.1 - 2 8.5 8.3 5.5 7.1 8.3 1.8 1 1 0 1 1 1 0 Double zinc ribbon RecR PF02132.15 EKE37801.1 - 8.2 6.1 9.6 5.5 6.6 0.9 2.6 2 1 0 2 2 2 0 RecR protein Sulfotransfer_3 PF13469.6 EKE37803.1 - 7e-20 72.3 0.0 1.9e-19 71.0 0.0 1.7 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EKE37803.1 - 0.0015 18.1 0.4 0.02 14.4 0.0 2.6 2 1 0 2 2 2 1 Sulfotransferase domain Y_phosphatase3 PF13350.6 EKE37804.1 - 4.7e-32 111.8 0.0 6.4e-32 111.4 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Phage_int_SAM_5 PF13102.6 EKE37804.1 - 0.024 15.0 0.1 0.044 14.1 0.1 1.4 1 0 0 1 1 1 0 Phage integrase SAM-like domain BRO1 PF03097.18 EKE37806.1 - 2.4e-58 197.8 12.7 2.4e-58 197.8 12.7 2.4 3 0 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EKE37806.1 - 9.6e-25 87.5 14.1 3.6e-24 85.6 14.1 2.1 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV Bromodomain PF00439.25 EKE37806.1 - 0.29 11.3 4.4 1.9 8.6 0.1 3.3 3 0 0 3 3 3 0 Bromodomain DUF1635 PF07795.11 EKE37806.1 - 1 9.2 4.7 18 5.1 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1635) Peptidase_C1 PF00112.23 EKE37807.1 - 1.8e-30 106.6 0.6 4.3e-30 105.4 0.6 1.6 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE37807.1 - 2.9e-09 37.2 5.4 1.2e-08 35.3 5.4 2.1 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Ras PF00071.22 EKE37808.1 - 1.8e-49 167.4 0.7 2.1e-49 167.2 0.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37808.1 - 1.6e-35 121.9 0.4 2.2e-35 121.5 0.4 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37808.1 - 4.3e-17 62.1 0.4 6.3e-17 61.6 0.4 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE37808.1 - 2.1e-07 31.0 0.2 0.0094 15.9 0.1 2.1 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE37808.1 - 2.6e-07 30.7 0.1 9.1e-07 29.0 0.1 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE37808.1 - 5.6e-06 25.9 0.2 6.8e-06 25.6 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE37808.1 - 1.5e-05 24.7 0.3 9e-05 22.1 0.3 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKE37808.1 - 0.00012 21.6 0.2 0.00044 19.7 0.2 1.9 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EKE37808.1 - 0.0002 21.0 0.1 0.00062 19.3 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_22 PF13401.6 EKE37808.1 - 0.00086 19.6 0.0 0.0027 18.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EKE37808.1 - 0.0019 18.6 0.0 0.002 18.5 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EKE37808.1 - 0.0064 16.7 0.0 0.0087 16.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EKE37808.1 - 0.0093 15.7 0.4 0.067 12.9 0.4 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 EKE37808.1 - 0.01 15.0 1.7 2.5 7.2 0.3 2.6 1 1 1 2 2 2 0 G-protein alpha subunit MCM PF00493.23 EKE37808.1 - 0.013 14.6 0.0 0.04 13.0 0.0 1.7 2 0 0 2 2 2 0 MCM P-loop domain AAA_24 PF13479.6 EKE37808.1 - 0.014 15.1 0.0 0.031 14.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKE37808.1 - 0.015 14.9 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EKE37808.1 - 0.018 14.4 0.0 0.049 13.0 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein Septin PF00735.18 EKE37808.1 - 0.038 13.3 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 Septin TsaE PF02367.17 EKE37808.1 - 0.047 13.7 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 EKE37808.1 - 0.059 13.4 0.0 0.098 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EKE37808.1 - 0.065 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 EKE37808.1 - 0.071 12.7 0.1 1.9 8.0 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 EKE37808.1 - 0.1 13.0 0.0 0.17 12.3 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EKE37808.1 - 0.15 11.8 0.2 0.32 10.8 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ras PF00071.22 EKE37809.1 - 1.6e-15 57.1 0.2 1.8e-15 56.9 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37809.1 - 0.0032 17.7 0.1 0.0057 16.9 0.1 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EKE37809.1 - 0.0039 16.6 0.0 0.0056 16.1 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE37809.1 - 0.0093 15.5 0.1 0.48 9.9 0.0 2.1 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain KTI12 PF08433.10 EKE37809.1 - 0.027 13.9 0.0 0.039 13.4 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Septin PF00735.18 EKE37809.1 - 0.046 13.0 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 Septin MMR_HSR1 PF01926.23 EKE37809.1 - 0.055 13.5 0.0 0.09 12.9 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 EKE37809.1 - 0.073 13.4 0.0 0.39 11.0 0.0 2.1 1 1 0 1 1 1 0 AAA domain DUF2937 PF11157.8 EKE37809.1 - 0.081 12.6 0.0 0.24 11.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DEAD PF00270.29 EKE37810.1 - 1.1e-19 70.8 0.0 4.7e-19 68.8 0.0 2.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE37810.1 - 4.8e-19 68.7 0.0 7e-18 65.0 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EKE37810.1 - 2e-13 50.9 4.8 1.6e-12 48.0 4.2 2.9 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.15 EKE37810.1 - 8.5e-06 25.9 0.0 8.5e-06 25.9 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit COA2 PF17051.5 EKE37810.1 - 0.098 12.7 0.2 2.7 8.1 0.0 2.6 2 0 0 2 2 2 0 Cytochrome C oxidase assembly factor 2 Fer4_2 PF12797.7 EKE37810.1 - 0.5 10.6 3.3 2.2 8.6 2.0 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.7 EKE37810.1 - 5.4 7.3 10.3 0.15 12.2 1.7 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain DHHC PF01529.20 EKE37811.1 - 7.5e-35 120.0 16.2 7.5e-35 120.0 16.2 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF2207 PF09972.9 EKE37811.1 - 1.7 7.4 12.1 0.64 8.7 0.6 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4832 PF16116.5 EKE37812.1 - 2e-10 40.9 1.2 3.3e-10 40.2 1.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4832) DUF4874 PF16173.5 EKE37812.1 - 1.6e-05 24.7 0.0 4.5e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4874) Med12-LCEWAV PF12145.8 EKE37812.1 - 0.12 11.1 0.4 3.3 6.5 0.1 2.1 2 0 0 2 2 2 0 Eukaryotic Mediator 12 subunit domain Vps8 PF12816.7 EKE37813.1 - 0.037 13.5 0.3 0.063 12.8 0.3 1.3 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 Peptidase_A22B PF04258.13 EKE37814.1 - 9.7e-36 123.7 29.3 3e-35 122.1 29.3 1.7 1 1 0 1 1 1 1 Signal peptide peptidase Peptidase_S74 PF13884.6 EKE37815.1 - 1.5e-15 57.2 0.0 3.9e-15 55.9 0.0 1.8 1 0 0 1 1 1 1 Chaperone of endosialidase BAR PF03114.18 EKE37815.1 - 0.054 13.1 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 BAR domain WD40 PF00400.32 EKE37816.1 - 1.1e-16 60.9 9.7 2.4e-06 28.1 0.3 6.4 8 0 0 8 8 8 4 WD domain, G-beta repeat WD40_like PF17005.5 EKE37816.1 - 0.00029 20.2 4.0 0.0056 16.1 0.0 3.4 3 1 0 4 4 4 2 WD40-like domain PH PF00169.29 EKE37817.1 - 4e-11 43.4 0.6 4e-11 43.4 0.6 1.9 2 0 0 2 2 2 1 PH domain SH3_1 PF00018.28 EKE37817.1 - 3e-10 39.6 0.1 5.7e-10 38.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EKE37817.1 - 1.8e-09 37.1 0.0 4.6e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EKE37817.1 - 9.8e-06 25.3 0.4 2e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.11 EKE37817.1 - 0.00012 22.2 0.1 0.0003 21.0 0.1 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain PH_8 PF15409.6 EKE37817.1 - 0.00014 22.1 0.3 0.00036 20.7 0.3 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 EKE37817.1 - 0.00026 21.4 3.4 0.0015 18.9 3.5 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain SH3_10 PF17902.1 EKE37817.1 - 0.0047 17.0 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 SH3 domain PRP1_N PF06424.12 EKE37817.1 - 0.0054 17.1 2.4 0.0054 17.1 2.4 2.0 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal Astro_capsid_p PF12226.8 EKE37817.1 - 1 8.4 8.8 1.3 8.1 8.2 1.5 2 0 0 2 2 2 0 Turkey astrovirus capsid protein DNA_pol_phi PF04931.13 EKE37817.1 - 3.5 5.6 15.6 6.5 4.7 15.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi MIP PF00230.20 EKE37818.1 - 0.024 14.3 8.9 0.051 13.3 8.9 1.6 1 1 0 1 1 1 0 Major intrinsic protein MMPL PF03176.15 EKE37818.1 - 0.56 9.1 1.7 0.8 8.6 1.7 1.2 1 0 0 1 1 1 0 MMPL family COG5 PF10392.9 EKE37820.1 - 0.00098 19.3 2.6 0.033 14.4 0.8 3.0 2 0 0 2 2 2 1 Golgi transport complex subunit 5 SesA PF17107.5 EKE37820.1 - 0.032 14.4 2.4 0.092 12.9 0.9 2.5 2 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases YfdX PF10938.8 EKE37820.1 - 0.13 12.2 0.4 0.32 10.9 0.4 1.7 1 0 0 1 1 1 0 YfdX protein Com_YlbF PF06133.11 EKE37820.1 - 2.2 8.9 18.7 0.3 11.7 1.5 3.5 3 1 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA LRR_8 PF13855.6 EKE37821.1 - 5.8e-07 29.2 21.2 0.00034 20.3 6.3 4.7 4 1 1 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 EKE37821.1 - 4.8e-05 23.6 30.0 0.00043 20.6 5.9 4.9 2 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EKE37821.1 - 0.041 13.4 13.7 0.14 11.6 7.0 2.8 2 1 1 3 3 3 0 Leucine-rich repeat PELOTA_1 PF15608.6 EKE37821.1 - 0.22 11.5 0.6 1.4 8.9 0.3 2.3 1 1 1 2 2 2 0 PELOTA RNA binding domain HEPN_Apea PF18739.1 EKE37821.1 - 1.7 9.1 6.2 0.66 10.4 2.6 2.2 2 1 0 2 2 2 0 Apea-like HEPN LRR_1 PF00560.33 EKE37821.1 - 1.8 9.4 0.1 1.8 9.4 0.1 6.0 5 1 0 5 5 5 0 Leucine Rich Repeat zf-Nse PF11789.8 EKE37822.1 - 3.1e-18 65.4 1.5 3.5e-18 65.2 0.5 1.7 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EKE37822.1 - 1.2e-08 34.9 0.2 6.8e-07 29.2 0.3 2.5 2 0 0 2 2 2 1 RING-type zinc-finger Rtf2 PF04641.12 EKE37822.1 - 3.5e-06 26.6 0.5 3.5e-06 26.6 0.5 1.7 1 1 1 2 2 2 1 Rtf2 RING-finger zf-MIZ PF02891.20 EKE37822.1 - 0.0052 16.5 0.3 0.009 15.7 0.3 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.6 EKE37822.1 - 0.013 15.3 0.3 0.041 13.7 0.1 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Use1 PF09753.9 EKE37822.1 - 0.036 13.8 1.3 0.051 13.3 1.3 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 zf-RING_2 PF13639.6 EKE37822.1 - 0.041 14.2 0.4 0.13 12.6 0.1 2.0 1 1 1 2 2 2 0 Ring finger domain Dynactin PF12455.8 EKE37822.1 - 0.064 12.5 0.1 0.064 12.5 0.1 1.5 2 0 0 2 2 2 0 Dynein associated protein zf-Di19 PF05605.12 EKE37822.1 - 0.11 12.8 0.6 1.8 8.9 0.1 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Fib_alpha PF08702.10 EKE37822.1 - 0.14 12.3 2.5 0.12 12.5 0.7 1.8 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family zf-C3HC4 PF00097.25 EKE37822.1 - 0.18 11.7 0.7 0.59 10.0 0.0 2.2 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) RBD-FIP PF09457.10 EKE37822.1 - 0.45 10.5 2.4 0.36 10.8 0.3 1.9 3 0 0 3 3 3 0 FIP domain Radical_SAM PF04055.21 EKE37823.1 - 2.1e-10 41.3 0.0 4.5e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EKE37823.1 - 9.4e-10 38.9 0.1 5.6e-09 36.4 0.0 2.1 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EKE37823.1 - 0.004 17.3 1.3 0.009 16.1 0.0 2.1 2 1 0 2 2 2 1 4Fe-4S single cluster domain Pkinase PF00069.25 EKE37824.1 - 4.9e-43 147.4 0.7 5.6e-43 147.2 0.7 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37824.1 - 2.1e-42 145.2 0.4 2.4e-42 145.0 0.4 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37824.1 - 5.6e-09 35.3 0.1 9.3e-09 34.5 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EKE37824.1 - 0.00064 18.8 0.5 0.001 18.2 0.2 1.4 1 1 0 1 1 1 1 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EKE37824.1 - 0.0018 17.6 0.0 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SWIRM PF04433.17 EKE37824.1 - 0.022 15.1 0.3 0.13 12.6 0.1 2.2 2 0 0 2 2 2 0 SWIRM domain TLD PF07534.16 EKE37826.1 - 1.1e-05 25.6 0.1 1.3e-05 25.5 0.1 1.0 1 0 0 1 1 1 1 TLD Sec7 PF01369.20 EKE37828.1 - 8.7e-44 149.4 12.9 1.1e-43 149.0 3.8 3.4 3 0 0 3 3 3 2 Sec7 domain Sec7_N PF12783.7 EKE37828.1 - 1.9e-19 70.1 2.0 1.9e-19 70.1 2.0 4.7 5 0 0 5 5 5 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EKE37828.1 - 6.7e-08 32.3 3.0 0.00032 20.5 0.2 4.7 4 0 0 4 4 4 2 Domain of unknown function (DUF1981) zf-HIT PF04438.16 EKE37828.1 - 0.26 11.2 9.1 0.52 10.2 9.1 1.6 1 0 0 1 1 1 0 HIT zinc finger PhoU PF01895.19 EKE37828.1 - 0.3 11.6 4.4 4.9 7.7 2.1 3.7 2 0 0 2 2 2 0 PhoU domain zf_C2H2_6 PF18450.1 EKE37828.1 - 2.1 8.1 6.2 6.4 6.6 6.2 1.7 1 0 0 1 1 1 0 Zinc Finger domain zf-MYND PF01753.18 EKE37828.1 - 4.4 7.5 11.2 8.9 6.5 11.2 1.5 1 0 0 1 1 1 0 MYND finger Beach PF02138.18 EKE37829.1 - 1.8e-70 237.5 0.4 4.8e-70 236.1 0.4 1.8 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EKE37829.1 - 0.011 15.8 1.9 0.017 15.2 0.1 2.4 2 1 0 2 2 2 0 PH domain associated with Beige/BEACH Topoisom_bac PF01131.20 EKE37830.1 - 6.7e-114 381.1 0.1 1.3e-113 380.2 0.0 1.4 2 0 0 2 2 2 1 DNA topoisomerase Toprim PF01751.22 EKE37830.1 - 6.8e-15 55.2 0.0 2.4e-14 53.4 0.0 2.0 1 0 0 1 1 1 1 Toprim domain Gp-FAR-1 PF05823.12 EKE37830.1 - 0.0044 17.4 3.2 2.1 8.7 0.4 3.1 3 0 0 3 3 3 2 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF4848 PF16140.5 EKE37830.1 - 0.058 12.9 1.5 0.14 11.7 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4848) Toprim_4 PF13662.6 EKE37830.1 - 0.14 12.6 0.0 0.34 11.4 0.0 1.7 1 0 0 1 1 1 0 Toprim domain BRCT PF00533.26 EKE37832.1 - 1.9e-05 25.0 1.6 7e-05 23.1 1.6 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain WWE PF02825.20 EKE37832.1 - 0.00047 20.7 0.1 0.00047 20.7 0.1 2.6 3 0 0 3 3 3 1 WWE domain BRCT_2 PF16589.5 EKE37832.1 - 0.028 14.8 0.5 0.028 14.8 0.5 2.2 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain SRP14 PF02290.15 EKE37832.1 - 0.06 13.7 2.8 0.061 13.7 0.4 2.2 2 0 0 2 2 2 0 Signal recognition particle 14kD protein PTCB-BRCT PF12738.7 EKE37832.1 - 0.081 12.9 0.7 0.19 11.7 0.7 1.6 1 1 0 1 1 1 0 twin BRCT domain EF-hand_7 PF13499.6 EKE37834.1 - 9.9e-21 74.0 9.9 2.9e-06 27.6 0.3 4.7 3 1 2 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.6 EKE37834.1 - 4.2e-20 69.9 11.7 0.0058 16.5 0.1 6.4 6 0 0 6 6 6 5 EF-hand domain EF-hand_1 PF00036.32 EKE37834.1 - 3.3e-17 60.7 14.2 0.0002 20.7 0.1 6.4 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.6 EKE37834.1 - 2.1e-10 40.3 1.9 0.0055 16.5 0.0 5.5 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 EKE37834.1 - 7e-10 38.0 6.4 0.00042 19.7 0.1 4.9 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.9 EKE37834.1 - 0.00024 21.4 6.4 0.1 12.9 1.5 4.1 3 1 1 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EKE37834.1 - 0.0037 17.5 0.0 3 8.2 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_4 PF12763.7 EKE37834.1 - 0.0097 15.8 3.5 0.28 11.2 0.4 3.2 3 1 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 EKE37834.1 - 0.013 15.4 8.1 23 4.9 0.1 5.1 4 1 1 5 5 5 0 EF hand IL5 PF02025.15 EKE37834.1 - 0.013 15.7 0.2 1.1 9.5 0.1 2.5 2 1 0 2 2 2 0 Interleukin 5 Pan3_PK PF18101.1 EKE37834.1 - 0.04 13.9 0.2 12 5.8 0.0 2.9 2 1 1 3 3 3 0 Pan3 Pseudokinase domain Beta-lactamase2 PF13354.6 EKE37834.1 - 0.065 12.8 0.0 1.6 8.3 0.0 2.5 2 1 0 3 3 3 0 Beta-lactamase enzyme family OST-HTH PF12872.7 EKE37834.1 - 0.12 12.2 0.0 0.51 10.2 0.0 2.1 1 0 0 1 1 1 0 OST-HTH/LOTUS domain EF-hand_14 PF17959.1 EKE37834.1 - 0.4 11.1 2.3 28 5.2 0.0 3.6 4 1 0 5 5 5 0 EF-hand domain Caleosin PF05042.13 EKE37834.1 - 2.8 7.8 6.3 12 5.7 0.1 3.3 4 0 0 4 4 4 0 Caleosin related protein Ribosomal_S24e PF01282.19 EKE37835.1 - 7.4e-30 102.7 0.3 1.3e-29 101.9 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e DUF1251 PF06856.11 EKE37835.1 - 0.043 13.5 0.0 0.06 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1251) Fib_alpha PF08702.10 EKE37836.1 - 0.019 15.2 1.9 0.019 15.2 1.9 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family RhoGAP PF00620.27 EKE37837.1 - 1.6e-27 96.2 0.2 6.2e-27 94.3 0.0 2.0 2 1 0 2 2 2 1 RhoGAP domain DUF3829 PF12889.7 EKE37837.1 - 0.0021 17.6 0.6 0.0059 16.1 0.6 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3829) FlgN PF05130.12 EKE37837.1 - 0.018 15.6 3.9 0.035 14.6 3.9 1.5 1 0 0 1 1 1 0 FlgN protein eIF2_C PF09173.11 EKE37838.1 - 2.1e-31 108.0 0.2 6.6e-31 106.4 0.2 1.9 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EKE37838.1 - 7.8e-22 77.8 2.5 7e-21 74.7 2.5 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EKE37838.1 - 7.6e-09 35.8 0.0 8.6e-08 32.5 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EKE37838.1 - 0.0049 16.9 0.0 0.0094 16.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE37838.1 - 0.0055 16.6 0.4 0.11 12.4 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 EKE37838.1 - 0.068 12.3 0.4 0.36 9.9 0.0 1.9 2 0 0 2 2 2 0 G-protein alpha subunit dNK PF01712.19 EKE37838.1 - 0.12 12.2 1.7 0.55 10.0 0.1 2.0 2 0 0 2 2 2 0 Deoxynucleoside kinase Dynamin_N PF00350.23 EKE37838.1 - 0.15 12.1 0.7 0.71 9.9 0.7 2.2 1 1 0 1 1 1 0 Dynamin family DUF720 PF05302.11 EKE37840.1 - 0.018 14.9 4.5 1.5 8.7 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF720) DUF948 PF06103.11 EKE37842.1 - 9.6 6.5 11.6 16 5.8 0.3 3.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) PGK PF00162.19 EKE37843.1 - 5.5e-146 486.4 0.0 6.2e-146 486.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF3172 PF11371.8 EKE37843.1 - 0.099 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3172) Spore_YunB PF09560.10 EKE37844.1 - 0.03 14.3 0.6 2 8.5 0.1 3.1 3 0 0 3 3 3 0 Sporulation protein YunB (Spo_YunB) Beach PF02138.18 EKE37845.1 - 1.3e-09 37.8 4.2 1.2e-08 34.7 0.9 3.2 3 0 0 3 3 3 1 Beige/BEACH domain Laminin_G_2 PF02210.24 EKE37845.1 - 0.0029 18.2 0.1 0.017 15.7 0.0 2.3 3 0 0 3 3 3 1 Laminin G domain Laminin_G_3 PF13385.6 EKE37845.1 - 0.05 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily PhoLip_ATPase_C PF16212.5 EKE37846.1 - 2.7e-49 168.2 33.9 2.7e-49 168.2 33.9 1.7 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 EKE37846.1 - 2.4e-11 43.5 0.0 5.1e-10 39.3 0.0 2.8 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EKE37846.1 - 5.4e-11 43.2 0.0 0.00028 21.2 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EKE37846.1 - 3.2e-08 33.3 0.0 3.2e-08 33.3 0.0 2.5 2 1 1 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EKE37846.1 - 0.00045 20.0 0.9 0.0019 18.0 0.3 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Arrestin_N PF00339.29 EKE37847.1 - 1.3e-07 31.8 0.2 6.3e-07 29.6 0.1 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain WW PF00397.26 EKE37847.1 - 7.3e-05 22.8 3.9 0.0021 18.1 0.6 3.6 3 0 0 3 3 3 1 WW domain Rad52_Rad22 PF04098.15 EKE37848.1 - 5.1e-44 149.9 0.0 7.2e-44 149.4 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein FF PF01846.19 EKE37849.1 - 0.0009 19.4 8.7 0.086 13.0 0.3 3.4 3 0 0 3 3 3 2 FF domain PSDC PF12588.8 EKE37849.1 - 0.023 14.6 2.1 0.023 14.6 2.1 2.4 2 1 1 3 3 3 0 Phophatidylserine decarboxylase WW PF00397.26 EKE37849.1 - 0.085 13.0 3.8 5.8 7.1 0.0 3.1 3 0 0 3 3 3 0 WW domain RhoGAP-FF1 PF16512.5 EKE37849.1 - 0.27 11.9 8.5 0.99 10.1 0.4 3.9 1 1 2 3 3 3 0 p190-A and -B Rho GAPs FF domain MerR_2 PF13591.6 EKE37849.1 - 0.75 9.7 8.2 0.17 11.8 0.5 3.3 2 1 1 3 3 3 0 MerR HTH family regulatory protein OppC_N PF12911.7 EKE37850.1 - 0.0039 17.1 0.0 0.0039 17.1 0.0 2.3 4 0 0 4 4 4 1 N-terminal TM domain of oligopeptide transport permease C Phage_Gp23 PF10669.9 EKE37850.1 - 0.17 12.2 0.1 0.33 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) DUF1230 PF06799.11 EKE37850.1 - 0.37 10.9 1.7 6.1 6.9 1.5 2.1 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 DUF2569 PF10754.9 EKE37850.1 - 1.6 9.2 13.4 24 5.4 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2569) NT-C2 PF10358.9 EKE37851.1 - 0.088 12.5 11.8 0.3 10.8 11.8 1.9 1 0 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins DUF1043 PF06295.12 EKE37852.1 - 0.26 11.3 0.2 0.26 11.3 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) Presenilin PF01080.17 EKE37853.1 - 2.9e-100 335.8 36.4 3.4e-71 240.1 23.7 2.8 2 1 1 3 3 3 2 Presenilin DUF3377 PF11857.8 EKE37853.1 - 0.22 11.5 8.1 0.59 10.1 0.7 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) Use1 PF09753.9 EKE37853.1 - 4.3 7.0 8.6 0.17 11.6 1.2 2.2 2 0 0 2 2 2 0 Membrane fusion protein Use1 TMEM144 PF07857.12 EKE37854.1 - 1.8e-81 273.7 14.2 2.1e-81 273.5 14.2 1.0 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 EKE37854.1 - 5.7e-10 39.0 21.6 4.5e-07 29.5 5.6 3.2 2 1 0 2 2 2 2 Sugar transport protein Ureide_permease PF07168.11 EKE37854.1 - 7.7e-05 21.6 4.7 0.052 12.3 3.1 2.5 1 1 1 2 2 2 2 Ureide permease DUF3810 PF12725.7 EKE37854.1 - 0.063 12.6 0.1 0.76 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Multi_Drug_Res PF00893.19 EKE37854.1 - 6.9 7.4 12.0 0.23 12.2 3.3 2.8 3 0 0 3 3 3 0 Small Multidrug Resistance protein Orthopox_A36R PF05950.11 EKE37855.1 - 0.17 12.0 5.5 0.5 10.5 5.5 1.8 1 0 0 1 1 1 0 Orthopoxvirus A36R protein IL31 PF15209.6 EKE37856.1 - 0.028 14.2 3.4 0.068 12.9 0.3 3.3 3 0 0 3 3 3 0 Interleukin 31 Vps39_2 PF10367.9 EKE37856.1 - 0.04 14.4 0.8 0.23 11.9 0.1 2.6 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 CNOT1_HEAT PF16418.5 EKE37856.1 - 0.26 11.4 6.6 0.12 12.5 0.9 3.4 3 1 1 4 4 4 0 CCR4-NOT transcription complex subunit 1 HEAT repeat zf-BED PF02892.15 EKE37856.1 - 4.4 7.4 6.9 66 3.7 0.2 3.9 3 0 0 3 3 3 0 BED zinc finger WH2 PF02205.20 EKE37857.1 - 2.4e-05 24.0 0.2 7.5e-05 22.4 0.2 1.9 1 0 0 1 1 1 1 WH2 motif BAR_3 PF16746.5 EKE37857.1 - 0.065 12.9 7.0 0.057 13.1 5.7 1.4 1 1 0 1 1 1 0 BAR domain of APPL family Atg14 PF10186.9 EKE37857.1 - 0.22 10.5 4.7 0.4 9.7 4.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5123 PF17161.4 EKE37857.1 - 0.29 12.2 2.7 0.66 11.1 2.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5123) SesA PF17107.5 EKE37857.1 - 0.81 9.9 5.4 1.4 9.1 4.2 2.0 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TMPIT PF07851.13 EKE37857.1 - 3.7 6.7 6.6 4.7 6.4 5.9 1.5 1 1 0 1 1 1 0 TMPIT-like protein XisI PF08869.11 EKE37858.1 - 0.076 13.4 0.0 0.076 13.4 0.0 2.8 3 1 1 4 4 4 0 XisI protein Lipin_mid PF16876.5 EKE37858.1 - 0.084 13.0 0.3 0.32 11.1 0.0 2.2 3 0 0 3 3 3 0 Lipin/Ned1/Smp2 multi-domain protein middle domain PX PF00787.24 EKE37860.1 - 9.2e-18 64.3 0.7 1.7e-17 63.5 0.7 1.4 1 0 0 1 1 1 1 PX domain fn3_6 PF17766.1 EKE37860.1 - 0.0051 17.0 1.1 0.0098 16.1 1.1 1.4 1 0 0 1 1 1 1 Fibronectin type-III domain Gp_dh_N PF00044.24 EKE37860.1 - 0.012 15.9 1.2 0.059 13.7 0.3 2.1 1 1 1 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Occludin_ELL PF07303.13 EKE37860.1 - 0.29 11.9 7.1 0.97 10.2 0.2 2.5 2 0 0 2 2 2 0 Occludin homology domain Rhomboid PF01694.22 EKE37861.1 - 6.1e-14 52.3 10.1 6.1e-14 52.3 10.1 1.9 2 0 0 2 2 2 1 Rhomboid family DUF2231 PF09990.9 EKE37861.1 - 3.2 8.2 6.2 0.22 12.0 0.4 2.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2231) PALP PF00291.25 EKE37862.1 - 2.2e-61 207.9 0.3 2.5e-61 207.7 0.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PROCN PF08083.11 EKE37863.1 - 3e-221 734.3 10.5 4.6e-221 733.7 10.5 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EKE37863.1 - 1.9e-111 371.2 0.2 3.6e-111 370.4 0.2 1.5 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EKE37863.1 - 3.3e-87 290.4 2.1 3.3e-87 290.4 2.1 2.1 2 0 0 2 2 2 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EKE37863.1 - 3.1e-77 257.7 1.1 8.9e-77 256.2 1.1 1.8 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EKE37863.1 - 5.8e-71 236.8 0.2 1.2e-70 235.7 0.2 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EKE37863.1 - 1.8e-42 143.6 0.6 5.8e-42 142.0 0.6 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EKE37863.1 - 2.3e-30 105.0 0.1 1.5e-29 102.5 0.0 2.4 2 0 0 2 2 2 1 PROCT (NUC072) domain JAB PF01398.21 EKE37863.1 - 0.00082 19.3 0.4 0.0054 16.7 0.1 2.5 3 0 0 3 3 3 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF1127 PF06568.11 EKE37863.1 - 0.074 12.8 0.1 0.074 12.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1127) Forkhead PF00250.18 EKE37864.1 - 0.56 10.5 4.2 1.7 8.9 2.0 2.5 1 1 1 2 2 2 0 Forkhead domain Pkinase PF00069.25 EKE37865.1 - 1.2e-61 208.4 1.8 1.2e-61 208.4 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37865.1 - 5.6e-34 117.6 0.0 1.4e-33 116.3 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE37865.1 - 5.6e-09 36.5 1.6 1.1e-08 35.6 0.1 2.2 2 0 0 2 2 2 1 PH domain Kinase-like PF14531.6 EKE37865.1 - 1.6e-06 27.7 0.0 0.00023 20.6 0.0 2.5 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EKE37865.1 - 1.3e-05 25.3 0.0 0.011 15.7 0.1 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family PH_9 PF15410.6 EKE37865.1 - 0.0097 16.3 0.1 0.085 13.2 0.1 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain RIO1 PF01163.22 EKE37865.1 - 0.02 14.5 0.1 0.075 12.6 0.1 2.0 1 0 0 1 1 1 0 RIO1 family EMG1 PF03587.14 EKE37867.1 - 2.3e-71 239.5 0.0 2.7e-71 239.3 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Pkinase_Tyr PF07714.17 EKE37868.1 - 5.8e-56 189.6 0.3 1.4e-55 188.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37868.1 - 5.4e-53 180.0 0.0 8.6e-53 179.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE37868.1 - 9.6e-09 34.5 0.0 1.6e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Cadherin_C_2 PF16492.5 EKE37868.1 - 0.0015 19.2 0.1 0.0052 17.5 0.1 2.0 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Otopetrin PF03189.13 EKE37868.1 - 0.0073 15.2 0.0 0.012 14.4 0.0 1.4 1 0 0 1 1 1 1 Otopetrin TMEM154 PF15102.6 EKE37868.1 - 0.023 14.6 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 EKE37868.1 - 0.024 15.5 0.1 0.076 13.9 0.1 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF2207 PF09972.9 EKE37868.1 - 0.067 11.9 0.1 0.11 11.2 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) VSP PF03302.13 EKE37868.1 - 0.088 11.7 159.8 0.06 12.2 29.5 7.0 3 2 4 7 7 7 0 Giardia variant-specific surface protein YajC PF02699.15 EKE37868.1 - 0.14 12.1 0.2 0.32 10.9 0.2 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit Syndecan PF01034.20 EKE37868.1 - 2.8 7.9 5.8 7.2 6.6 5.8 1.7 1 0 0 1 1 1 0 Syndecan domain SKG6 PF08693.10 EKE37868.1 - 7.6 6.0 10.3 21 4.6 10.3 1.8 1 1 0 1 1 1 0 Transmembrane alpha-helix domain zf-rbx1 PF12678.7 EKE37870.1 - 1.6e-23 82.8 9.7 2.1e-23 82.3 9.7 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EKE37870.1 - 3.7e-18 65.4 7.5 4.3e-18 65.2 7.5 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EKE37870.1 - 2.3e-06 27.9 13.6 0.00013 22.2 13.6 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EKE37870.1 - 0.0003 20.6 10.6 0.0023 17.8 10.6 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE37870.1 - 0.00051 19.8 12.7 0.042 13.7 12.7 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H_2 PF13832.6 EKE37870.1 - 0.0017 18.5 3.5 0.0022 18.1 3.5 1.3 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-RING_UBOX PF13445.6 EKE37870.1 - 0.02 14.9 7.9 0.089 12.8 7.9 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-Nse PF11789.8 EKE37870.1 - 0.026 14.4 0.2 0.047 13.5 0.2 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 EKE37870.1 - 0.076 13.2 8.3 0.14 12.3 8.3 1.5 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 EKE37870.1 - 0.22 11.4 9.7 0.99 9.3 4.7 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EKE37870.1 - 0.24 11.4 10.8 1.8 8.6 10.9 2.1 1 1 1 2 2 2 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EKE37870.1 - 0.27 10.9 13.8 0.2 11.3 5.8 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EKE37870.1 - 0.31 10.8 13.6 21 5.0 13.6 2.6 1 1 0 1 1 1 0 RING-like zinc finger PHD PF00628.29 EKE37870.1 - 1.9 8.5 11.4 14 5.6 11.4 2.1 1 1 0 1 1 1 0 PHD-finger RINGv PF12906.7 EKE37870.1 - 6.4 7.0 16.7 3.2e+02 1.6 14.3 2.8 1 1 1 2 2 2 0 RING-variant domain zf-RING-like PF08746.11 EKE37870.1 - 9.3 6.7 12.4 90 3.5 12.4 2.2 1 1 0 1 1 1 0 RING-like domain Importin_rep_4 PF18808.1 EKE37871.1 - 1.6e-06 28.3 5.9 0.00045 20.5 0.0 3.7 3 0 0 3 3 3 2 Importin repeat HEAT PF02985.22 EKE37871.1 - 4.9e-06 26.4 5.7 23 5.6 0.0 7.7 8 0 0 8 8 8 1 HEAT repeat Vac14_Fab1_bd PF12755.7 EKE37871.1 - 0.015 15.9 0.7 18 6.0 0.0 4.0 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 EKE37871.1 - 0.057 13.6 2.4 13 6.0 0.1 3.6 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Herpes_ICP4_N PF03584.15 EKE37871.1 - 0.096 12.5 0.0 1.5 8.6 0.0 2.4 2 0 0 2 2 2 0 Herpesvirus ICP4-like protein N-terminal region PseudoU_synth_1 PF01416.20 EKE37872.1 - 2.3e-29 102.0 0.0 2.9e-28 98.5 0.0 2.2 2 0 0 2 2 2 1 tRNA pseudouridine synthase Pkinase_Tyr PF07714.17 EKE37874.1 - 3e-37 128.3 0.0 7.5e-37 127.0 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37874.1 - 3e-33 115.3 1.5 4.9e-32 111.3 0.0 2.8 2 0 0 2 2 2 1 Protein kinase domain Myotub-related PF06602.14 EKE37874.1 - 5.8e-12 45.2 5.5 5.8e-12 45.2 5.5 3.1 3 1 0 3 3 3 1 Myotubularin-like phosphatase domain LRR_8 PF13855.6 EKE37874.1 - 1.2e-09 37.8 28.5 0.00018 21.2 4.8 5.1 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EKE37874.1 - 0.001 19.4 39.8 0.073 13.5 7.9 7.3 4 1 4 8 8 8 5 Leucine Rich repeats (2 copies) BRAP2 PF07576.12 EKE37874.1 - 0.015 15.5 1.0 8.9 6.6 0.0 4.2 3 0 0 3 3 3 0 BRCA1-associated protein 2 DUF948 PF06103.11 EKE37875.1 - 0.29 11.4 5.2 7.6 6.9 0.6 4.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) PI_PP_I PF18363.1 EKE37875.1 - 0.82 9.9 4.4 1.6 9.0 0.3 3.4 3 1 0 3 3 3 0 Phosphoinositide phosphatase insertion domain APG6_N PF17675.1 EKE37875.1 - 4.9 7.7 9.2 0.39 11.2 2.4 2.6 2 1 1 3 3 3 0 Apg6 coiled-coil region WWE PF02825.20 EKE37876.1 - 1.5e-06 28.6 3.6 1.5e-06 28.6 3.6 2.2 2 1 0 2 2 2 1 WWE domain BRCT_2 PF16589.5 EKE37876.1 - 0.00042 20.7 0.2 0.0011 19.3 0.2 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Hexokinase_1 PF00349.21 EKE37876.1 - 0.036 14.0 0.1 0.081 12.8 0.1 1.6 1 1 0 1 1 1 0 Hexokinase RhoGAP PF00620.27 EKE37877.1 - 9.5e-15 54.7 1.3 6.3e-14 52.1 1.3 2.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EKE37877.1 - 0.026 15.0 0.8 1.1 9.8 0.1 3.3 2 0 0 2 2 2 0 PH domain Mvb12 PF09452.10 EKE37877.1 - 3.8 8.0 6.4 7.5 7.0 0.5 4.1 2 1 2 4 4 4 0 ESCRT-I subunit Mvb12 WXG100 PF06013.12 EKE37877.1 - 4.1 7.7 6.0 23 5.3 0.2 4.2 3 1 1 4 4 4 0 Proteins of 100 residues with WXG Sec1 PF00995.23 EKE37878.1 - 8.3e-88 296.1 14.0 1.4e-87 295.3 14.0 1.3 1 1 0 1 1 1 1 Sec1 family Imm3 PF14425.6 EKE37878.1 - 4.5 7.3 6.8 2.5 8.2 0.7 3.3 4 0 0 4 4 4 0 Immunity protein Imm3 Abhydrolase_1 PF00561.20 EKE37879.1 - 0.0081 15.8 0.0 0.017 14.8 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF5494 PF17598.2 EKE37879.1 - 0.059 13.5 0.0 0.17 12.0 0.0 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5494) Abhydrolase_6 PF12697.7 EKE37879.1 - 0.064 13.8 0.0 0.092 13.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.25 EKE37880.1 - 7.6e-75 251.7 1.7 9.6e-75 251.3 1.7 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37880.1 - 2.2e-42 145.1 0.8 2.9e-42 144.8 0.8 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EKE37880.1 - 2.9e-08 33.9 0.4 7.1e-08 32.7 0.4 1.6 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 EKE37880.1 - 1.1e-05 24.9 0.0 0.00012 21.6 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EKE37880.1 - 1.2e-05 24.4 0.7 1.6e-05 24.1 0.7 1.4 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EKE37880.1 - 0.0015 18.2 0.1 0.0023 17.5 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EKE37880.1 - 0.0032 16.9 0.2 0.005 16.2 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKE37880.1 - 0.014 14.2 6.0 0.0088 14.9 2.1 2.2 2 1 0 2 2 2 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EKE37880.1 - 0.019 14.5 0.6 0.039 13.5 0.6 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 EKE37880.1 - 0.027 14.4 0.0 3.3 7.6 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family TMEM154 PF15102.6 EKE37881.1 - 0.007 16.3 0.1 0.018 15.0 0.1 1.6 1 0 0 1 1 1 1 TMEM154 protein family Pkinase PF00069.25 EKE37883.1 - 6.1e-51 173.3 0.0 9.9e-51 172.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37883.1 - 3.8e-20 72.3 0.0 1.2e-19 70.6 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37883.1 - 0.0017 17.2 0.0 0.0023 16.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKE37883.1 - 0.011 15.1 0.1 0.18 11.1 0.1 2.6 2 1 0 2 2 2 0 Kinase-like APH PF01636.23 EKE37883.1 - 0.027 14.4 0.0 0.075 13.0 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EKE37883.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UvrD_C PF13361.6 EKE37883.1 - 0.16 11.3 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain UPF0184 PF03670.13 EKE37885.1 - 0.03 14.7 1.5 0.059 13.8 0.1 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) BRCA-2_OB3 PF09104.10 EKE37885.1 - 0.1 12.3 1.2 0.1 12.3 1.2 1.1 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 DUF1366 PF07104.11 EKE37885.1 - 0.18 11.5 3.9 0.2 11.3 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1366) DivIC PF04977.15 EKE37886.1 - 0.023 14.5 2.9 0.031 14.0 1.1 1.9 2 0 0 2 2 2 0 Septum formation initiator HicB-like_2 PF15970.5 EKE37886.1 - 0.33 11.1 2.7 0.38 10.9 2.0 1.5 1 1 1 2 2 2 0 HicB_like antitoxin of bacterial toxin-antitoxin system FlaC_arch PF05377.11 EKE37886.1 - 2.4 8.6 8.1 0.84 10.1 2.3 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Occludin_ELL PF07303.13 EKE37887.1 - 0.042 14.6 2.0 0.042 14.6 2.0 2.2 2 0 0 2 2 2 0 Occludin homology domain RNase_3_N PF18497.1 EKE37887.1 - 0.28 11.4 4.4 0.14 12.4 0.6 2.4 2 0 0 2 2 2 0 Ribonuclease III N-terminal domain YabA PF06156.13 EKE37887.1 - 0.4 11.3 6.9 0.59 10.8 2.5 2.6 2 0 0 2 2 2 0 Initiation control protein YabA HALZ PF02183.18 EKE37887.1 - 0.68 10.2 4.5 13 6.1 0.6 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper FlaC_arch PF05377.11 EKE37887.1 - 0.75 10.2 6.4 0.72 10.3 1.6 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF3800 PF12686.7 EKE37887.1 - 1.2 9.8 5.6 67 4.1 5.6 3.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) ZapB PF06005.12 EKE37887.1 - 1.2 9.6 14.3 6.9 7.2 7.7 2.6 2 0 0 2 2 2 0 Cell division protein ZapB DUF2205 PF10224.9 EKE37887.1 - 1.8 8.7 7.3 3.6 7.6 0.1 3.0 3 0 0 3 3 3 0 Short coiled-coil protein TSC22 PF01166.18 EKE37887.1 - 1.8 8.9 7.6 11 6.4 2.4 2.9 2 0 0 2 2 2 0 TSC-22/dip/bun family Med9 PF07544.13 EKE37887.1 - 2.7 8.1 9.5 0.32 11.1 4.6 2.0 2 0 0 2 2 1 0 RNA polymerase II transcription mediator complex subunit 9 BLOC1_2 PF10046.9 EKE37887.1 - 4.4 7.7 11.6 0.95 9.8 2.8 3.0 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 EKE37887.1 - 9.7 6.0 9.2 21 5.0 2.0 2.6 2 0 0 2 2 2 0 Septum formation initiator WD40 PF00400.32 EKE37888.1 - 2.8e-10 40.6 8.7 0.00013 22.7 0.1 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat F-box PF00646.33 EKE37888.1 - 0.026 14.4 0.0 0.078 12.9 0.0 1.9 1 0 0 1 1 1 0 F-box domain F-box_4 PF15966.5 EKE37888.1 - 0.059 13.3 0.0 0.26 11.2 0.0 2.1 1 0 0 1 1 1 0 F-box E1_DerP2_DerF2 PF02221.15 EKE37889.1 - 3.3e-17 63.2 1.7 4e-17 62.9 1.7 1.1 1 0 0 1 1 1 1 ML domain eIF-5a PF01287.20 EKE37890.1 - 5.1e-25 87.4 0.3 7.4e-25 86.8 0.3 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EKE37890.1 - 8.1e-05 22.6 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain IF4E PF01652.18 EKE37891.1 - 1.2e-16 60.9 0.3 1.7e-16 60.4 0.3 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E RhoGEF PF00621.20 EKE37892.1 - 3e-64 216.6 46.4 6.7e-26 91.6 2.2 6.1 6 0 0 6 6 6 5 RhoGEF domain OLF PF02191.16 EKE37892.1 - 0.00034 20.2 0.6 1.2 8.6 0.0 3.4 3 0 0 3 3 3 2 Olfactomedin-like domain NOG1_N PF17835.1 EKE37892.1 - 0.0004 20.4 12.2 0.13 12.2 0.8 4.9 4 0 0 4 4 4 2 NOG1 N-terminal helical domain IQ_SEC7_PH PF16453.5 EKE37892.1 - 0.013 15.5 7.3 0.8 9.7 0.1 4.0 4 0 0 4 4 4 0 PH domain SieB PF14163.6 EKE37892.1 - 0.59 9.6 7.5 1.2 8.7 0.0 3.6 4 0 0 4 4 4 0 Super-infection exclusion protein B RTT107_BRCT_5 PF16770.5 EKE37894.1 - 3.8e-09 36.3 0.0 3.8e-09 36.3 0.0 4.0 4 2 2 6 6 6 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 EKE37894.1 - 0.0019 18.6 5.2 0.01 16.2 0.3 3.5 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EKE37894.1 - 0.55 10.7 10.9 0.71 10.3 0.2 3.8 4 0 0 4 4 4 0 BRCT domain, a BRCA1 C-terminus domain DTW PF03942.15 EKE37895.1 - 9.1e-20 71.2 1.5 1.3e-19 70.7 1.5 1.2 1 0 0 1 1 1 1 DTW domain zf-B_box PF00643.24 EKE37895.1 - 1.5 9.0 12.4 0.093 12.9 6.8 1.9 2 0 0 2 2 2 0 B-box zinc finger zinc_ribbon_9 PF14369.6 EKE37895.1 - 4.2 7.7 10.9 1.2 9.4 0.2 3.2 3 0 0 3 3 3 0 zinc-ribbon Stealth_CR2 PF11380.8 EKE37896.1 - 6.6e-29 100.3 1.2 6.6e-29 100.3 1.2 3.0 3 0 0 3 3 3 1 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 EKE37896.1 - 6.7e-06 25.9 0.0 1.5e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR4 PF17103.5 EKE37896.1 - 0.0043 16.9 3.0 0.0051 16.7 0.3 2.6 3 0 0 3 3 3 1 Stealth protein CR4, conserved region 4 EF-hand_7 PF13499.6 EKE37898.1 - 1.7e-16 60.4 8.8 4.9e-08 33.3 0.6 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EKE37898.1 - 1.1e-15 55.9 12.5 0.00014 21.2 0.8 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EKE37898.1 - 7.3e-13 47.3 9.9 0.0097 15.8 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EKE37898.1 - 5.1e-12 44.7 9.5 0.0037 16.7 0.6 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EKE37898.1 - 2.4e-09 36.9 13.7 1.1e-05 25.2 1.5 3.9 2 1 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EKE37898.1 - 1.2e-05 25.6 0.1 0.13 12.5 0.0 2.9 2 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EKE37898.1 - 3e-05 24.2 0.5 0.23 11.8 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain Dockerin_1 PF00404.18 EKE37898.1 - 0.002 18.3 2.0 0.098 12.9 0.3 2.7 2 1 1 3 3 3 2 Dockerin type I domain DUF3024 PF11225.8 EKE37898.1 - 0.21 11.9 0.3 4.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3024) EF-hand_4 PF12763.7 EKE37898.1 - 0.3 11.1 8.0 1.4 8.9 0.3 3.2 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand SPRY PF00622.28 EKE37899.1 - 2e-12 47.3 0.3 3.9e-12 46.4 0.3 1.5 1 0 0 1 1 1 1 SPRY domain Sec63 PF02889.16 EKE37900.1 - 1.3e-10 40.8 2.4 2.5e-10 40.0 2.0 1.5 1 1 0 1 1 1 1 Sec63 Brl domain zf-3CxxC PF13695.6 EKE37900.1 - 0.022 15.2 0.2 0.092 13.2 0.2 2.1 1 0 0 1 1 1 0 Zinc-binding domain ASFV_J13L PF05568.11 EKE37900.1 - 0.37 10.5 3.5 4.9 6.9 0.8 2.4 2 0 0 2 2 2 0 African swine fever virus J13L protein NAD_kinase PF01513.21 EKE37901.1 - 1.9e-13 50.3 0.1 8.9e-13 48.1 0.1 1.8 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EKE37901.1 - 0.054 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Hydrolase_3 PF08282.12 EKE37902.1 - 2.4e-39 135.6 0.0 4.7e-39 134.7 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKE37902.1 - 0.0023 18.3 0.0 0.092 13.0 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Aldo_ket_red PF00248.21 EKE37902.1 - 0.098 11.8 0.1 0.73 9.0 0.1 2.0 2 0 0 2 2 2 0 Aldo/keto reductase family HAD PF12710.7 EKE37902.1 - 0.15 12.5 1.0 70 3.8 0.0 3.0 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase Aa_trans PF01490.18 EKE37903.1 - 1e-26 93.6 38.8 1.5e-26 93.1 38.8 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EKE37903.1 - 0.5 9.3 32.0 5.5 5.9 32.0 2.7 1 1 0 1 1 1 0 Tryptophan/tyrosine permease family NPCC PF08058.11 EKE37903.1 - 3 7.9 8.4 1.6 8.8 0.4 2.9 3 0 0 3 3 3 0 Nuclear pore complex component Pkinase PF00069.25 EKE37904.1 - 3.3e-22 79.1 0.2 5.1e-22 78.5 0.2 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37904.1 - 1.1e-13 51.0 0.0 1.3e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37904.1 - 3e-06 26.3 0.1 3.9e-06 25.9 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKE37904.1 - 0.017 15.1 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-RING_2 PF13639.6 EKE37905.1 - 2.5e-10 40.5 8.5 2.5e-10 40.5 8.5 1.9 2 0 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.7 EKE37905.1 - 5e-09 36.3 5.9 5e-09 36.3 5.9 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EKE37905.1 - 1.7e-07 30.9 10.5 2.5e-06 27.2 10.5 2.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EKE37905.1 - 1.5e-06 27.8 6.5 4.4e-06 26.3 6.5 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EKE37905.1 - 1.6e-05 24.7 5.6 6.8e-05 22.6 5.6 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE37905.1 - 3.9e-05 23.4 8.8 0.00011 22.0 8.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE37905.1 - 5.2e-05 23.0 4.2 0.00025 20.8 3.7 2.3 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EKE37905.1 - 6e-05 22.9 6.0 0.00013 21.8 6.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EKE37905.1 - 0.00022 21.2 8.3 0.00066 19.7 8.3 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EKE37905.1 - 0.00084 19.3 5.3 0.0025 17.8 4.5 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EKE37905.1 - 0.001 18.6 5.8 0.0032 17.0 5.8 1.8 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EKE37905.1 - 0.016 15.4 5.2 0.069 13.3 5.2 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Rtf2 PF04641.12 EKE37905.1 - 0.2 11.0 1.0 0.48 9.8 0.7 1.7 2 0 0 2 2 2 0 Rtf2 RING-finger RINGv PF12906.7 EKE37905.1 - 0.3 11.2 3.9 1 9.5 3.9 1.9 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 EKE37905.1 - 0.44 10.4 4.0 1.4 8.8 4.0 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EKE37905.1 - 1.1 9.6 4.0 3.1 8.2 4.0 1.9 1 1 0 1 1 1 0 RING-like domain TLD PF07534.16 EKE37906.1 - 0.00019 21.7 0.2 0.0004 20.6 0.2 1.7 1 0 0 1 1 1 1 TLD VPS9 PF02204.18 EKE37907.1 - 3.2e-16 59.4 2.7 7.4e-16 58.3 2.7 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain IKBKB_SDD PF18397.1 EKE37907.1 - 0.024 14.0 0.7 0.024 14.0 0.7 1.8 1 1 0 2 2 2 0 IQBAL scaffold dimerization domain EF-hand_2 PF09068.11 EKE37907.1 - 0.12 12.6 6.5 0.61 10.2 1.3 2.4 1 1 1 2 2 2 0 EF hand LepA_C PF06421.12 EKE37907.1 - 0.16 12.1 1.7 0.44 10.7 0.2 2.1 2 0 0 2 2 2 0 GTP-binding protein LepA C-terminus FANCI_S2 PF14676.6 EKE37907.1 - 1.2 9.4 5.5 0.93 9.8 0.1 2.5 3 0 0 3 3 3 0 FANCI solenoid 2 RRM_1 PF00076.22 EKE37908.1 - 4.3e-14 52.1 0.0 9.2e-14 51.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EKE37908.1 - 7e-09 35.4 2.4 1.3e-08 34.5 2.4 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EKE37908.1 - 0.0081 16.0 1.2 0.015 15.1 1.2 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-ribbon_3 PF13248.6 EKE37908.1 - 0.16 11.4 1.1 0.31 10.5 1.1 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Lectin_leg-like PF03388.13 EKE37909.1 - 3e-21 75.8 0.0 3e-21 75.8 0.0 1.7 2 0 0 2 2 2 1 Legume-like lectin family Bact_lectin PF18483.1 EKE37909.1 - 1.3e-08 35.1 1.9 4.8e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 Bacterial lectin Radical_SAM_C PF16199.5 EKE37910.1 - 2.1e-30 104.5 0.1 4.4e-30 103.5 0.1 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EKE37910.1 - 4.5e-19 69.4 1.4 6.7e-19 68.9 0.4 1.7 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EKE37910.1 - 1.3e-09 38.3 0.0 2.5e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EKE37910.1 - 0.002 18.1 0.1 0.0043 17.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RhoGEF PF00621.20 EKE37911.1 - 4.6e-21 75.9 10.0 4.6e-21 75.9 10.0 3.4 4 2 0 4 4 4 1 RhoGEF domain IQ PF00612.27 EKE37911.1 - 0.0053 16.4 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif TFIIA_gamma_N PF02268.16 EKE37911.1 - 0.092 12.8 0.1 1.7 8.8 0.0 3.1 3 0 0 3 3 3 0 Transcription initiation factor IIA, gamma subunit, helical domain BORG_CEP PF14957.6 EKE37911.1 - 0.37 11.9 4.6 1 10.5 4.6 1.8 1 0 0 1 1 1 0 Cdc42 effector CH_2 PF06294.11 EKE37913.1 - 3.3 7.9 7.3 6.5 6.9 0.0 3.0 4 0 0 4 4 4 0 CH-like domain in sperm protein Haspin_kinase PF12330.8 EKE37914.1 - 8e-10 38.2 2.0 1e-09 37.8 1.3 1.5 1 1 1 2 2 2 1 Haspin like kinase domain Choline_kinase PF01633.20 EKE37914.1 - 0.0039 16.8 0.5 0.0071 15.9 0.3 1.4 1 1 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EKE37914.1 - 0.0086 15.7 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 EKE37914.1 - 0.024 13.9 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase APH PF01636.23 EKE37914.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF846 PF05832.12 EKE37915.1 - 3e-41 140.7 16.4 3.6e-41 140.4 16.4 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Promethin PF16015.5 EKE37915.1 - 0.0049 16.8 0.2 0.0049 16.8 0.2 2.2 2 0 0 2 2 2 1 Promethin zf-HIT PF04438.16 EKE37916.1 - 1.1e-05 25.2 7.9 2e-05 24.4 7.9 1.3 1 0 0 1 1 1 1 HIT zinc finger zf-Mss51 PF13824.6 EKE37916.1 - 0.21 11.7 3.7 0.44 10.7 3.7 1.5 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Proteasome PF00227.26 EKE37917.1 - 2e-37 128.6 0.2 2.3e-37 128.3 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit SH3_1 PF00018.28 EKE37918.1 - 3.1e-15 55.5 0.0 5.8e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EKE37918.1 - 6.9e-13 48.2 0.0 1.1e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EKE37918.1 - 2.9e-11 42.9 0.0 6.3e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain FCH PF00611.23 EKE37918.1 - 3e-07 30.6 1.8 6.2e-07 29.6 0.1 2.4 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_10 PF17902.1 EKE37918.1 - 0.0077 16.3 0.0 0.019 15.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain Fib_alpha PF08702.10 EKE37918.1 - 0.013 15.6 1.1 0.013 15.6 1.1 3.0 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family TIR-like PF10137.9 EKE37918.1 - 0.029 14.3 1.8 6.4 6.8 0.0 2.8 2 1 1 3 3 3 0 Predicted nucleotide-binding protein containing TIR-like domain IFT57 PF10498.9 EKE37918.1 - 0.077 11.9 14.1 0.015 14.3 8.7 2.3 1 1 2 3 3 3 0 Intra-flagellar transport protein 57 Spc7 PF08317.11 EKE37918.1 - 0.18 10.7 15.5 0.013 14.4 10.6 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein RabGAP-TBC PF00566.18 EKE37918.1 - 0.24 11.0 2.2 0.33 10.6 0.3 2.1 1 1 0 2 2 2 0 Rab-GTPase-TBC domain Spectrin PF00435.21 EKE37918.1 - 0.29 11.6 7.0 0.18 12.3 3.0 2.7 1 1 1 2 2 2 0 Spectrin repeat ERM PF00769.19 EKE37918.1 - 0.61 9.9 16.6 1.1 9.1 16.5 1.6 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF4482 PF14818.6 EKE37918.1 - 0.77 10.6 9.1 0.24 12.3 5.9 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4482) HAUS-augmin3 PF14932.6 EKE37918.1 - 3.4 7.2 16.7 6.3 6.3 16.7 1.5 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 BRE1 PF08647.11 EKE37918.1 - 3.5 7.8 28.8 0.69 10.0 0.8 4.3 5 1 0 5 5 4 0 BRE1 E3 ubiquitin ligase IPK PF03770.16 EKE37920.1 - 2.7e-38 131.8 0.9 3.6e-38 131.4 0.9 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase CPSF_A PF03178.15 EKE37921.1 - 3.4e-36 125.2 1.3 4.1e-36 124.9 0.3 1.6 2 0 0 2 2 2 1 CPSF A subunit region UBA PF00627.31 EKE37922.1 - 4.7e-17 61.5 0.3 6.8e-09 35.5 0.1 3.3 3 0 0 3 3 3 2 UBA/TS-N domain ubiquitin PF00240.23 EKE37922.1 - 1.1e-12 47.6 0.3 2.2e-12 46.6 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKE37922.1 - 0.00018 21.2 0.3 0.0004 20.1 0.3 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like XPC-binding PF09280.11 EKE37922.1 - 0.0066 16.2 0.7 0.018 14.7 0.7 1.7 1 0 0 1 1 1 1 XPC-binding domain UBA_2 PF08587.11 EKE37922.1 - 0.0099 16.0 0.9 0.0099 16.0 0.9 2.7 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) UBA_3 PF09288.10 EKE37922.1 - 0.018 14.9 0.2 0.093 12.6 0.1 2.3 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain RecX PF02631.16 EKE37922.1 - 0.021 15.3 0.9 2.4 8.6 0.0 2.9 3 0 0 3 3 3 0 RecX family Ubiquitin_4 PF18036.1 EKE37922.1 - 0.024 14.7 0.1 11 6.1 0.0 2.6 2 0 0 2 2 2 0 Ubiquitin-like domain HOIP-UBA PF16678.5 EKE37922.1 - 0.082 12.9 2.4 0.18 11.8 0.0 2.5 3 1 0 3 3 3 0 HOIP UBA domain pair eIF-5_eIF-2B PF01873.17 EKE37922.1 - 0.096 12.6 0.0 0.3 11.0 0.0 1.9 1 0 0 1 1 1 0 Domain found in IF2B/IF5 Imm1 PF14430.6 EKE37922.1 - 0.32 11.6 2.0 0.65 10.7 0.4 2.1 1 1 0 2 2 2 0 Immunity protein Imm1 FumaraseC_C PF10415.9 EKE37922.1 - 0.85 10.1 2.5 12 6.4 0.1 3.4 3 0 0 3 3 3 0 Fumarase C C-terminus HBS1_N PF08938.10 EKE37922.1 - 1.2 9.5 0.0 1.2 9.5 0.0 4.4 3 1 0 3 3 2 0 HBS1 N-terminus Pex14_N PF04695.13 EKE37922.1 - 1.8 9.2 15.6 2.6 8.7 7.6 3.0 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Alpha-amylase_C PF02806.18 EKE37923.1 - 4.8e-21 75.0 0.0 1.3e-20 73.7 0.0 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 EKE37923.1 - 1.1e-15 58.0 2.8 5.3e-14 52.5 0.1 2.5 2 1 1 3 3 3 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 EKE37923.1 - 2.2e-06 27.9 0.0 4.9e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) GHL6 PF14871.6 EKE37923.1 - 0.011 15.9 0.1 0.026 14.7 0.0 1.6 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase 6 PTCB-BRCT PF12738.7 EKE37924.1 - 0.00058 19.7 0.2 0.0014 18.5 0.2 1.7 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EKE37924.1 - 0.0012 19.2 0.4 0.0012 19.2 0.4 3.0 4 0 0 4 4 3 1 BRCA1 C Terminus (BRCT) domain Cep57_CLD_2 PF14197.6 EKE37924.1 - 0.01 15.9 2.8 0.01 15.9 2.8 3.3 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 FUSC PF04632.12 EKE37924.1 - 0.22 10.0 1.6 0.29 9.6 1.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1664 PF07889.12 EKE37924.1 - 0.32 11.0 28.3 0.54 10.3 3.5 3.3 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EKE37924.1 - 0.33 9.8 38.9 0.2 10.5 14.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Methyltransf_15 PF09445.10 EKE37924.1 - 1.2 8.7 5.1 1.1 8.8 0.8 2.3 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase CENP-F_leu_zip PF10473.9 EKE37924.1 - 2.3 8.2 38.1 5.6 7.0 13.8 2.7 1 1 2 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4618 PF15397.6 EKE37924.1 - 3 7.2 39.2 10 5.4 28.3 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4618) THOC7 PF05615.13 EKE37924.1 - 3.4 7.9 28.4 21 5.4 1.8 3.5 1 1 2 3 3 3 0 Tho complex subunit 7 COG2 PF06148.11 EKE37924.1 - 3.8 7.6 21.7 29 4.7 7.2 3.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Fez1 PF06818.15 EKE37924.1 - 7.4 7.0 31.8 2.5 8.5 16.7 2.4 1 1 1 2 2 2 0 Fez1 zf-C4H2 PF10146.9 EKE37924.1 - 9.1 6.5 32.5 26 5.0 32.1 2.1 1 1 0 1 1 1 0 Zinc finger-containing protein CDP-OH_P_transf PF01066.21 EKE37926.1 - 2e-16 60.5 0.1 2e-16 60.5 0.1 4.0 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Cpta_toxin PF07254.12 EKE37926.1 - 0.32 11.0 6.5 0.68 9.9 5.6 2.1 1 1 0 1 1 1 0 Membrane-bound toxin component of toxin-antitoxin system Ras PF00071.22 EKE37927.1 - 1.3e-50 171.1 1.3 1.6e-50 170.9 1.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37927.1 - 4.3e-32 110.9 0.4 6.7e-32 110.2 0.4 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37927.1 - 4.5e-13 49.0 0.5 5.5e-13 48.7 0.5 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE37927.1 - 7.5e-09 35.4 1.4 1.2e-06 28.3 1.4 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE37927.1 - 3.5e-06 27.1 0.1 5.2e-06 26.5 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE37927.1 - 0.00035 20.1 0.1 0.00047 19.6 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EKE37927.1 - 0.00035 20.0 0.6 0.0005 19.5 0.4 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 EKE37927.1 - 0.0053 16.8 0.1 0.0081 16.2 0.1 1.6 1 1 0 1 1 1 1 Dynamin family FeoB_N PF02421.18 EKE37927.1 - 0.011 15.3 0.2 2.7 7.5 0.2 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP-synt_ab PF00006.25 EKE37927.1 - 0.084 12.5 0.0 0.1 12.2 0.0 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.6 EKE37927.1 - 0.23 11.2 2.6 0.45 10.2 2.6 1.8 1 1 0 1 1 1 0 AAA domain adh_short PF00106.25 EKE37928.1 - 1.2e-26 93.4 0.1 7.1e-26 90.9 0.1 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EKE37928.1 - 1.6e-13 50.8 0.0 1.1e-12 48.0 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EKE37928.1 - 1.6e-07 31.1 0.0 2.1e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EKE37928.1 - 4.9e-07 29.8 0.0 7.6e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EKE37928.1 - 1.7e-05 24.1 0.1 2.2e-05 23.7 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EKE37928.1 - 6.1e-05 22.3 0.0 0.00029 20.1 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EKE37928.1 - 0.0083 15.6 0.1 0.011 15.2 0.1 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EKE37928.1 - 0.014 15.3 0.0 0.023 14.6 0.0 1.4 1 1 0 1 1 1 0 NAD(P)H-binding NmrA PF05368.13 EKE37928.1 - 0.055 13.0 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family NAD_binding_2 PF03446.15 EKE37928.1 - 0.082 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase THF_DHG_CYH_C PF02882.19 EKE37928.1 - 0.13 11.6 0.2 0.34 10.2 0.1 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain SBP_bac_3 PF00497.20 EKE37928.1 - 0.19 11.2 0.0 0.33 10.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Pkinase_Tyr PF07714.17 EKE37929.1 - 1.4e-49 168.7 0.0 2.3e-49 168.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE37929.1 - 5.7e-39 134.1 0.0 8.7e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TMEM131_like PF12371.8 EKE37929.1 - 1.8 8.9 4.9 1 9.7 0.3 2.5 2 0 0 2 2 2 0 Transmembrane protein 131-like D123 PF07065.14 EKE37930.1 - 7.6e-28 97.5 6.7 9.9e-28 97.2 6.7 1.1 1 0 0 1 1 1 1 D123 R2K_2 PF18299.1 EKE37930.1 - 8.8e-06 25.6 0.0 1.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 EKE37930.1 - 0.0016 18.5 0.0 0.0025 17.8 0.0 1.3 1 1 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 Intein_splicing PF14890.6 EKE37930.1 - 4.9 7.1 7.3 16 5.5 0.3 2.9 2 1 1 3 3 3 0 Intein splicing domain PCNA_N PF00705.18 EKE37931.1 - 1.6e-33 115.1 2.8 1.6e-33 115.1 2.8 2.0 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EKE37931.1 - 5.9e-27 94.4 2.0 3.4e-26 91.9 0.1 2.2 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain DUF555 PF04475.12 EKE37931.1 - 0.022 15.1 0.1 0.066 13.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF555) Hus1 PF04005.12 EKE37931.1 - 0.031 13.4 0.1 0.067 12.3 0.1 1.5 1 1 0 1 1 1 0 Hus1-like protein Rad9 PF04139.13 EKE37931.1 - 0.041 13.3 2.1 0.07 12.6 2.1 1.4 1 1 0 1 1 1 0 Rad9 Oxysterol_BP PF01237.18 EKE37932.1 - 9.4e-71 238.6 4.9 1.3e-69 234.9 0.0 3.1 2 1 0 2 2 2 1 Oxysterol-binding protein UBD PF16455.5 EKE37932.1 - 0.06 13.6 0.0 0.16 12.2 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-binding domain HAD_2 PF13419.6 EKE37933.1 - 1.6e-11 44.6 0.0 2.2e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EKE37933.1 - 0.0035 17.8 0.0 0.0044 17.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EKE37933.1 - 0.0038 17.2 0.0 0.0054 16.8 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Mem_trans PF03547.18 EKE37934.1 - 6.8 5.0 7.0 13 4.0 7.0 1.6 1 1 0 1 1 1 0 Membrane transport protein AAA_11 PF13086.6 EKE37934.1 - 7.9 6.2 11.9 18 5.0 11.9 1.7 1 0 0 1 1 1 0 AAA domain Myb_DNA-bind_4 PF13837.6 EKE37935.1 - 1.2e-05 25.6 0.9 1.9e-05 24.9 0.9 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF608 PF04685.13 EKE37935.1 - 0.0047 16.2 0.1 0.0056 15.9 0.1 1.2 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region Myb_DNA-bind_3 PF12776.7 EKE37935.1 - 0.0074 17.2 2.8 0.017 16.1 2.9 1.7 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 EKE37935.1 - 0.018 15.3 0.5 0.033 14.5 0.3 1.6 1 1 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF573 PF04504.14 EKE37935.1 - 0.023 15.4 1.4 0.044 14.4 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF573 NPL PF17800.1 EKE37936.1 - 7.1e-08 33.0 0.1 7.8e-08 32.8 0.1 1.1 1 0 0 1 1 1 1 Nucleoplasmin-like domain ArnB_C PF18677.1 EKE37938.1 - 0.018 15.1 0.2 0.027 14.6 0.2 1.3 1 0 0 1 1 1 0 Archaellum regulatory network B, C-terminal domain BLYB PF05289.11 EKE37938.1 - 0.019 15.2 1.7 0.031 14.5 1.5 1.4 1 1 0 1 1 1 0 Borrelia hemolysin accessory protein Jnk-SapK_ap_N PF09744.9 EKE37938.1 - 0.021 15.0 4.2 0.14 12.3 1.3 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 SLATT_6 PF18169.1 EKE37938.1 - 0.078 12.6 0.6 0.088 12.4 0.6 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 DUF5074 PF16819.5 EKE37939.1 - 1.8 8.6 9.4 30 4.7 0.1 4.4 3 1 1 4 4 4 0 Domain of unknown function (DUF5074) RasGEF PF00617.19 EKE37940.1 - 1.9e-45 155.2 0.3 5.8e-45 153.7 0.3 1.9 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE37940.1 - 8.8e-10 38.8 0.3 3.3e-09 36.9 0.3 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif zf-RING_4 PF14570.6 EKE37940.1 - 0.0028 17.4 6.8 0.0073 16.1 6.8 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.6 EKE37940.1 - 0.11 12.9 10.2 0.4 11.1 10.2 2.0 1 0 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.6 EKE37940.1 - 0.13 12.1 11.5 0.71 9.8 11.5 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EKE37940.1 - 0.14 12.0 7.7 0.55 10.1 7.7 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 EKE37940.1 - 0.17 11.6 5.6 0.55 9.9 5.6 1.9 1 0 0 1 1 1 0 P-11 zinc finger zf-C3HC4_3 PF13920.6 EKE37940.1 - 6.4 6.7 13.6 2.1 8.3 10.3 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.14 EKE37940.1 - 8.9 6.2 11.3 0.87 9.5 0.1 3.8 4 0 0 4 4 4 0 Rad50 zinc hook motif NRBF2_MIT PF17169.4 EKE37941.1 - 0.11 12.7 0.9 0.16 12.2 0.3 1.6 2 0 0 2 2 2 0 MIT domain of nuclear receptor-binding factor 2 CRAL_TRIO_N PF03765.15 EKE37941.1 - 0.17 12.1 0.3 0.17 12.1 0.3 2.3 2 1 0 2 2 2 0 CRAL/TRIO, N-terminal domain HBD PF18534.1 EKE37941.1 - 0.2 11.8 2.6 0.78 9.9 0.2 2.4 2 1 1 3 3 3 0 Helical bundle domain Stealth_CR2 PF11380.8 EKE37943.1 - 3.2e-39 133.4 1.2 1.1e-38 131.7 1.2 2.0 1 0 0 1 1 1 1 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 EKE37943.1 - 1.5e-16 60.0 0.1 1.5e-16 60.0 0.1 2.1 3 0 0 3 3 3 1 Stealth protein CR3, conserved region 3 Stealth_CR1 PF17101.5 EKE37943.1 - 1.5e-10 40.6 0.1 3.2e-10 39.6 0.1 1.6 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Stealth_CR4 PF17103.5 EKE37943.1 - 3.5e-10 39.6 0.4 1.1e-09 38.0 0.1 2.0 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 C2 PF00168.30 EKE37944.1 - 8.5e-19 67.8 3.1 3.3e-16 59.5 0.1 3.4 3 0 0 3 3 3 2 C2 domain EF-hand_7 PF13499.6 EKE37944.1 - 3.6e-11 43.3 14.4 5.5e-06 26.7 0.6 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EKE37944.1 - 4.5e-11 41.7 5.4 0.00034 20.3 0.3 4.0 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 EKE37944.1 - 4.4e-10 38.4 6.9 0.00027 20.3 0.3 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EKE37944.1 - 2.3e-09 37.0 1.1 0.00019 21.2 0.0 3.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EKE37944.1 - 0.00088 18.7 0.6 0.15 11.6 0.2 3.0 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.6 EKE37944.1 - 0.0099 16.2 0.2 0.098 13.0 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 EKE37944.1 - 0.048 14.0 1.7 12 6.3 0.3 2.6 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region SusD-like_3 PF14322.6 EKE37944.1 - 2 8.7 6.2 5.8 7.2 0.2 3.0 3 0 0 3 3 3 0 Starch-binding associating with outer membrane MFS_1 PF07690.16 EKE37945.1 - 4.2e-27 95.0 8.5 2.6e-26 92.4 1.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Tom22 PF04281.13 EKE37945.1 - 0.2 11.5 3.1 0.39 10.5 3.1 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 DNA_pol_phi PF04931.13 EKE37945.1 - 1.8 6.6 11.3 2.3 6.2 11.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi AAA_12 PF13087.6 EKE37946.1 - 2.5e-43 148.0 0.2 8.1e-43 146.4 0.2 1.9 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EKE37946.1 - 2.9e-31 109.2 0.1 3.6e-17 63.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain UPF1_Zn_bind PF09416.10 EKE37946.1 - 8.4e-10 38.8 8.9 3.7e-09 36.7 8.9 2.2 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) AAA_19 PF13245.6 EKE37946.1 - 1.4e-08 35.2 0.0 3.4e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EKE37946.1 - 1.6e-08 34.5 0.0 6.1e-07 29.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EKE37946.1 - 1.5e-06 28.1 0.3 1.3 8.7 0.0 3.5 2 1 0 3 3 3 3 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 EKE37946.1 - 0.0002 21.1 0.0 0.00048 19.9 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_24 PF13479.6 EKE37946.1 - 0.00029 20.6 0.0 0.00058 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EKE37946.1 - 0.001 19.1 0.0 0.0066 16.4 0.0 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea DUF2075 PF09848.9 EKE37946.1 - 0.0011 18.3 0.7 0.41 9.8 0.0 3.6 4 0 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 EKE37946.1 - 0.0012 18.4 0.0 0.0036 16.9 0.0 1.9 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 EKE37946.1 - 0.0013 18.3 0.0 0.028 13.9 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 EKE37946.1 - 0.0025 18.1 0.0 0.0085 16.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain RsgA_GTPase PF03193.16 EKE37946.1 - 0.0036 17.2 0.0 0.014 15.4 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 EKE37946.1 - 0.0076 16.4 0.1 0.14 12.3 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA PF00004.29 EKE37946.1 - 0.0087 16.5 0.0 0.026 14.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 EKE37946.1 - 0.019 14.4 0.3 0.78 9.1 0.0 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Spuma_A9PTase PF03539.14 EKE37946.1 - 0.057 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RNA_helicase PF00910.22 EKE37946.1 - 0.076 13.4 0.1 0.74 10.2 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 EKE37946.1 - 0.12 12.9 0.0 0.52 10.9 0.0 2.1 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EKE37946.1 - 0.22 10.5 0.0 0.47 9.5 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 EKE37946.1 - 0.23 11.0 0.0 0.56 9.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain TMEM247 PF15444.6 EKE37950.1 - 2.8 7.9 8.8 3.8 7.5 7.7 1.7 1 1 1 2 2 2 0 Transmembrane protein 247 Ras PF00071.22 EKE37951.1 - 5.2e-52 175.7 0.0 6.2e-52 175.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37951.1 - 3.3e-24 85.4 0.0 4.8e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37951.1 - 5.1e-09 35.8 0.0 7.1e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE37951.1 - 0.00011 21.6 0.0 0.00023 20.6 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE37951.1 - 0.0058 16.2 0.0 0.026 14.1 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE37951.1 - 0.044 13.9 0.0 0.063 13.4 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase FRQ PF09421.10 EKE37951.1 - 0.15 10.1 0.0 0.18 9.8 0.0 1.0 1 0 0 1 1 1 0 Frequency clock protein Sec7 PF01369.20 EKE37952.1 - 5.8e-38 130.4 2.4 5.8e-38 130.4 2.4 2.6 2 1 0 2 2 2 1 Sec7 domain DUF1981 PF09324.10 EKE37952.1 - 1.3e-16 60.2 11.7 1.1e-15 57.2 1.2 5.6 5 0 0 5 5 5 1 Domain of unknown function (DUF1981) zf-MYND PF01753.18 EKE37952.1 - 0.00095 19.2 11.4 0.0021 18.1 11.4 1.6 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.6 EKE37952.1 - 0.0027 17.8 8.6 0.0071 16.4 6.3 2.5 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-RING_2 PF13639.6 EKE37952.1 - 6 7.3 11.5 25 5.3 11.5 2.2 1 0 0 1 1 1 0 Ring finger domain DENN PF02141.21 EKE37953.1 - 1.1e-19 71.2 2.4 1.1e-19 71.2 2.4 1.7 2 0 0 2 2 2 1 DENN (AEX-3) domain SPA PF08616.10 EKE37953.1 - 0.00028 20.8 0.1 0.00056 19.8 0.1 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Metallophos PF00149.28 EKE37954.1 - 2e-13 51.3 0.1 4.2e-13 50.3 0.1 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE37954.1 - 5.8e-08 33.1 0.1 7.9e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ubiquitin PF00240.23 EKE37955.1 - 0.0084 15.8 0.0 0.023 14.4 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKE37955.1 - 0.054 13.3 0.1 0.15 12.0 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EKE37955.1 - 0.38 11.3 4.1 4.2 8.0 4.1 2.8 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain DNA_pol_A_exo1 PF01612.20 EKE37956.1 - 1.8e-42 145.0 1.0 3.8e-42 144.0 1.0 1.6 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 EKE37956.1 - 1e-07 31.8 0.0 2.7e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 HRDC domain Repressor_Mnt PF11423.8 EKE37956.1 - 0.02 14.7 0.2 0.065 13.0 0.2 1.9 1 0 0 1 1 1 0 Regulatory protein Mnt DUF3456 PF11938.8 EKE37956.1 - 0.19 12.3 1.8 0.35 11.4 0.4 2.2 2 1 0 2 2 2 0 TLR4 regulator and MIR-interacting MSAP SNARE PF05739.19 EKE37957.1 - 3.1e-12 46.3 1.5 8.6e-12 44.9 1.5 1.9 1 0 0 1 1 1 1 SNARE domain DUF2207 PF09972.9 EKE37957.1 - 0.0083 14.9 4.0 0.02 13.7 0.1 2.0 1 1 1 2 2 2 1 Predicted membrane protein (DUF2207) DUF3040 PF11239.8 EKE37957.1 - 0.012 15.9 0.0 0.02 15.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF842 PF05811.13 EKE37957.1 - 0.025 14.3 0.4 0.055 13.2 0.4 1.7 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) Spc7 PF08317.11 EKE37957.1 - 0.033 13.1 8.2 0.12 11.2 1.6 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF2508 PF10704.9 EKE37957.1 - 0.049 13.8 1.1 0.049 13.8 1.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) Spectrin PF00435.21 EKE37957.1 - 0.066 13.7 2.7 4.6 7.8 0.2 2.4 2 0 0 2 2 2 0 Spectrin repeat BLOC1_2 PF10046.9 EKE37957.1 - 0.11 12.8 8.0 0.074 13.4 2.2 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3899 PF13038.6 EKE37957.1 - 0.16 12.5 0.3 0.44 11.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) Casc1_N PF15927.5 EKE37957.1 - 1.1 8.9 5.0 10 5.8 1.3 2.5 2 1 1 3 3 3 0 Cancer susceptibility candidate 1 N-terminus DUF2203 PF09969.9 EKE37957.1 - 5 7.9 6.4 17 6.1 0.6 2.4 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF2718 PF10918.8 EKE37958.1 - 0.048 14.2 1.2 0.072 13.6 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2718) BTB_2 PF02214.22 EKE37959.1 - 0.00043 20.6 6.5 0.00091 19.5 0.7 3.1 2 1 2 4 4 4 1 BTB/POZ domain SPRY PF00622.28 EKE37959.1 - 0.0031 17.6 0.2 0.0073 16.4 0.2 1.8 1 1 0 1 1 1 1 SPRY domain GIDA_assoc PF13932.6 EKE37959.1 - 0.073 13.2 7.0 0.11 12.6 7.0 1.2 1 0 0 1 1 1 0 GidA associated domain Nas2_N PF18265.1 EKE37959.1 - 4.5 7.3 7.2 0.32 11.0 0.2 2.6 3 0 0 3 3 3 0 Nas2 N_terminal domain DEAD PF00270.29 EKE37960.1 - 3.5e-45 153.9 0.1 1.1e-44 152.3 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE37960.1 - 1.5e-28 99.3 0.1 9.8e-28 96.7 0.2 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE37960.1 - 0.0037 17.3 0.0 0.011 15.8 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PRAI PF00697.22 EKE37960.1 - 0.11 12.3 0.1 0.26 11.0 0.0 1.5 1 1 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Ribosomal_S28e PF01200.18 EKE37961.1 - 7.7e-29 99.5 1.4 8.9e-29 99.3 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S28e Mic1 PF07035.12 EKE37963.1 - 4.8e-18 65.4 5.0 8.6e-18 64.5 5.0 1.4 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like Vps39_1 PF10366.9 EKE37963.1 - 0.006 16.8 2.1 0.014 15.6 2.1 1.7 1 1 0 1 1 1 1 Vacuolar sorting protein 39 domain 1 PIN_5 PF08745.11 EKE37963.1 - 0.1 12.0 1.2 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 PINc domain ribonuclease Prp18 PF02840.15 EKE37963.1 - 0.15 12.1 1.7 1.3 9.0 1.7 2.2 1 1 0 1 1 1 0 Prp18 domain Glycos_transf_4 PF00953.21 EKE37964.1 - 4.2e-27 95.1 18.4 4.2e-27 95.1 18.4 2.3 3 0 0 3 3 3 1 Glycosyl transferase family 4 DUF1129 PF06570.11 EKE37964.1 - 0.016 14.7 1.2 0.016 14.7 1.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) IRK PF01007.20 EKE37964.1 - 0.066 13.0 9.2 1.2 8.9 1.0 3.2 2 2 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain Cnd1 PF12717.7 EKE37965.1 - 0.038 14.0 0.1 0.038 14.0 0.1 3.3 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 LRR_5 PF13306.6 EKE37967.1 - 2.2e-75 250.7 41.0 1.8e-27 95.9 1.1 4.0 1 1 3 5 5 5 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE37967.1 - 3.4e-05 23.5 0.5 0.3 10.9 0.1 4.8 4 2 3 7 7 7 1 Leucine rich repeat LRR_4 PF12799.7 EKE37967.1 - 0.027 14.9 2.9 9.3 6.8 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) FNIP PF05725.12 EKE37967.1 - 0.28 11.4 21.5 5.9 7.1 0.1 5.9 5 0 0 5 5 5 0 FNIP Repeat RNA_pol_Rpb1_3 PF04983.18 EKE37967.1 - 0.45 10.4 4.2 0.71 9.8 1.7 2.5 2 1 0 2 2 2 0 RNA polymerase Rpb1, domain 3 DUF2105 PF09878.9 EKE37968.1 - 0.0012 18.6 0.2 0.0014 18.4 0.2 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2105) CENP-F_leu_zip PF10473.9 EKE37969.1 - 0.0019 18.2 5.3 0.0043 17.1 5.3 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cep57_CLD_2 PF14197.6 EKE37969.1 - 0.0022 18.0 9.1 0.012 15.7 5.5 3.0 2 1 0 2 2 2 1 Centrosome localisation domain of PPC89 APG6_N PF17675.1 EKE37969.1 - 0.0086 16.6 0.5 0.018 15.6 0.5 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region DivIC PF04977.15 EKE37969.1 - 0.012 15.4 3.0 0.072 12.9 0.2 2.9 2 1 1 3 3 3 0 Septum formation initiator Jnk-SapK_ap_N PF09744.9 EKE37969.1 - 0.019 15.2 2.3 0.055 13.7 2.3 1.7 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Cnn_1N PF07989.11 EKE37969.1 - 0.028 14.6 1.8 0.028 14.6 1.8 2.6 2 1 1 3 3 2 0 Centrosomin N-terminal motif 1 FlaC_arch PF05377.11 EKE37969.1 - 0.034 14.6 1.7 0.034 14.6 1.7 3.9 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) DUF1697 PF08002.11 EKE37969.1 - 0.047 14.1 1.4 0.92 10.0 0.1 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF1697) Tropomyosin_1 PF12718.7 EKE37969.1 - 0.21 11.7 3.8 0.42 10.8 3.8 1.4 1 0 0 1 1 1 0 Tropomyosin like DUF3450 PF11932.8 EKE37969.1 - 0.38 10.0 3.7 0.77 9.0 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) bZIP_2 PF07716.15 EKE37969.1 - 0.52 10.4 5.7 3.8 7.7 1.0 3.1 3 0 0 3 3 3 0 Basic region leucine zipper DivIVA PF05103.13 EKE37969.1 - 0.54 10.3 4.3 0.33 11.0 1.1 2.3 2 1 1 3 3 3 0 DivIVA protein DUF1664 PF07889.12 EKE37969.1 - 0.54 10.3 4.2 0.3 11.1 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) JIP_LZII PF16471.5 EKE37969.1 - 0.7 10.1 9.3 0.75 10.0 6.7 2.3 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II bZIP_1 PF00170.21 EKE37969.1 - 1.2 9.3 8.2 1.9 8.6 1.6 2.6 1 1 1 2 2 2 0 bZIP transcription factor ZapB PF06005.12 EKE37969.1 - 1.3 9.5 5.8 1.3 9.5 2.8 2.2 1 1 1 2 2 2 0 Cell division protein ZapB TMF_DNA_bd PF12329.8 EKE37969.1 - 1.4 9.0 13.5 0.39 10.7 2.9 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.10 EKE37969.1 - 6.7 6.9 13.3 0.16 12.1 4.8 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Shugoshin_N PF07558.11 EKE37969.1 - 7.6 6.5 9.7 19 5.2 0.6 3.0 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region DUF4806 PF16064.5 EKE37969.1 - 8.7 6.7 8.5 4.6 7.6 0.6 3.7 2 2 0 3 3 3 0 Domain of unknown function (DUF4806) TLD PF07534.16 EKE37971.1 - 2.9e-08 34.0 1.1 3.2e-08 33.9 1.1 1.2 1 0 0 1 1 1 1 TLD KID PF02524.14 EKE37971.1 - 0.45 10.8 3.3 0.59 10.5 0.2 2.5 2 0 0 2 2 2 0 KID repeat EF-hand_7 PF13499.6 EKE37972.1 - 1.3e-15 57.6 0.0 3.8e-06 27.3 0.0 2.6 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EKE37972.1 - 1.1e-11 43.4 2.0 0.00047 19.5 0.1 3.6 3 1 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EKE37972.1 - 1.6e-10 40.0 0.2 0.01 15.7 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 EKE37972.1 - 1.3e-08 34.6 1.6 0.0047 16.8 0.1 3.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EKE37972.1 - 1.7e-08 33.5 0.3 4.3e-05 22.8 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 EKE37972.1 - 1.2e-06 28.7 0.0 6.4e-06 26.4 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 EKE37972.1 - 0.029 14.5 0.0 8.3 6.7 0.0 2.4 2 0 0 2 2 2 0 Dockerin type I domain Peptidase_C50 PF03568.17 EKE37972.1 - 0.054 12.6 0.1 0.061 12.4 0.1 1.2 1 0 0 1 1 1 0 Peptidase family C50 ANAPC4_WD40 PF12894.7 EKE37973.1 - 2.7e-09 37.2 0.4 0.0032 17.8 0.1 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EKE37973.1 - 1.3e-08 35.3 9.4 0.00057 20.6 0.0 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat Pkinase PF00069.25 EKE37974.1 - 1.3e-51 175.6 0.0 1.9e-51 175.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37974.1 - 4.7e-51 173.6 0.0 6.6e-51 173.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37974.1 - 4.5e-06 25.7 0.0 7e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase VSP PF03302.13 EKE37974.1 - 0.0025 16.8 39.0 0.14 11.0 11.4 2.8 1 1 1 2 2 2 2 Giardia variant-specific surface protein MLANA PF14991.6 EKE37974.1 - 0.0059 16.9 0.3 0.014 15.7 0.3 1.6 1 0 0 1 1 1 1 Protein melan-A TssO PF17561.2 EKE37974.1 - 0.071 13.2 4.9 0.035 14.2 2.1 1.9 2 0 0 2 2 2 0 Type VI secretion system, TssO Insulin_TMD PF17870.1 EKE37974.1 - 0.074 13.1 5.6 0.19 11.8 5.6 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment OAD_gamma PF04277.13 EKE37974.1 - 0.14 12.7 1.8 0.28 11.8 1.8 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Vpu PF00558.19 EKE37974.1 - 2.5 7.9 4.6 5 7.0 4.6 1.4 1 0 0 1 1 1 0 Vpu protein Sigma_reg_N PF13800.6 EKE37974.1 - 3.5 8.0 7.3 1.5 9.1 3.8 2.1 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Mon1 PF03164.14 EKE37975.1 - 6.6e-49 167.1 10.3 2.1e-48 165.4 10.3 1.7 1 1 0 1 1 1 1 Trafficking protein Mon1 IBP39 PF11422.8 EKE37975.1 - 0.025 14.4 0.2 0.091 12.5 0.2 2.0 1 0 0 1 1 1 0 Initiator binding protein 39 kDa Zap1_zf2 PF18217.1 EKE37975.1 - 0.1 12.6 2.9 0.39 10.7 0.1 2.7 2 0 0 2 2 2 0 Zap1 zinc finger 2 TIG PF01833.24 EKE37976.1 - 2.3e-10 40.4 1.0 3.9e-10 39.7 1.0 1.4 1 0 0 1 1 1 1 IPT/TIG domain ubiquitin PF00240.23 EKE37976.1 - 0.032 14.0 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family tRNA-synt_1b PF00579.25 EKE37977.1 - 5.5e-09 35.8 1.7 9.8e-08 31.7 0.1 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (W and Y) SH3_1 PF00018.28 EKE37978.1 - 1.6e-12 46.8 0.0 2.8e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EKE37978.1 - 1.3e-10 41.0 0.0 2.1e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EKE37978.1 - 1.3e-07 31.2 0.0 4.4e-07 29.5 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain FCH PF00611.23 EKE37978.1 - 7.8e-05 22.9 0.4 7.8e-05 22.9 0.4 2.6 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain Fib_alpha PF08702.10 EKE37978.1 - 0.0021 18.2 18.0 0.0052 17.0 1.8 3.3 1 1 2 3 3 3 2 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 EKE37978.1 - 0.0053 16.8 4.4 0.0053 16.8 4.4 2.9 3 0 0 3 3 3 1 TPR/MLP1/MLP2-like protein DUF745 PF05335.13 EKE37978.1 - 0.06 13.1 8.3 2.1 8.0 5.6 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF745) FYRC PF05965.14 EKE37978.1 - 0.063 13.5 1.0 0.13 12.4 0.0 2.1 2 1 1 3 3 3 0 F/Y rich C-terminus HemX PF04375.14 EKE37978.1 - 0.25 10.6 6.0 0.45 9.7 0.1 2.4 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase TMPIT PF07851.13 EKE37978.1 - 1.6 7.9 19.7 0.65 9.2 14.7 2.2 1 1 1 2 2 2 0 TMPIT-like protein DUF1664 PF07889.12 EKE37978.1 - 4 7.5 15.2 2 8.5 1.5 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 EKE37978.1 - 4.3 7.7 8.8 4.4 7.6 2.4 3.3 2 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Fez1 PF06818.15 EKE37978.1 - 4.3 7.7 18.0 1.2 9.6 14.0 2.0 1 1 0 1 1 1 0 Fez1 ZYG-11_interact PF05884.12 EKE37978.1 - 7.3 5.9 5.8 2.1 7.7 1.5 2.1 1 1 1 2 2 2 0 Interactor of ZYG-11 Fip1 PF05182.13 EKE37980.1 - 7.9e-06 25.3 0.2 1.7e-05 24.3 0.2 1.6 1 0 0 1 1 1 1 Fip1 motif DUF3298 PF11738.8 EKE37980.1 - 0.3 12.2 2.5 0.35 11.9 1.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3298) RasGEF PF00617.19 EKE37983.1 - 3.8e-53 180.3 0.2 8.8e-52 175.9 0.0 2.6 2 1 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EKE37983.1 - 5.2e-09 36.3 0.1 1.6e-08 34.7 0.1 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif Ribosomal_L32e PF01655.18 EKE37984.1 - 4e-44 149.4 0.2 4.8e-44 149.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Ldh_2 PF02615.14 EKE37986.1 - 2.7e-116 388.4 0.0 3.1e-116 388.2 0.0 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase FdtA PF05523.11 EKE37986.1 - 0.17 11.6 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 WxcM-like, C-terminal VSP PF03302.13 EKE37987.1 - 0.00013 21.0 18.8 0.00013 21.0 18.8 2.2 1 1 1 2 2 2 1 Giardia variant-specific surface protein Marek_A PF02124.15 EKE37987.1 - 0.015 15.1 0.2 0.022 14.6 0.2 1.2 1 0 0 1 1 1 0 Marek's disease glycoprotein A Orf78 PF06024.12 EKE37987.1 - 0.018 15.3 0.1 0.032 14.5 0.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) Sigma_reg_N PF13800.6 EKE37987.1 - 0.02 15.2 1.6 0.035 14.4 1.6 1.4 1 0 0 1 1 1 0 Sigma factor regulator N-terminal TMEM154 PF15102.6 EKE37987.1 - 0.044 13.7 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Ephrin_rec_like PF07699.13 EKE37987.1 - 0.057 13.2 2.6 0.057 13.2 2.6 5.8 2 2 3 6 6 5 0 Putative ephrin-receptor like DUF2207 PF09972.9 EKE37987.1 - 0.073 11.8 0.4 0.096 11.4 0.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LapA_dom PF06305.11 EKE37987.1 - 0.11 12.3 0.4 0.17 11.7 0.4 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF5385 PF17359.2 EKE37987.1 - 0.16 11.5 1.9 0.22 11.0 1.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Podoplanin PF05808.11 EKE37987.1 - 0.2 11.8 0.3 0.29 11.3 0.3 1.2 1 0 0 1 1 1 0 Podoplanin Baculo_11_kDa PF06143.11 EKE37987.1 - 0.88 9.2 6.1 0.38 10.4 2.6 1.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family DUF3139 PF11337.8 EKE37987.1 - 5.7 7.7 6.5 6.1 7.6 4.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Ribosomal_L40e PF01020.17 EKE37988.1 - 1.2e-29 102.0 8.0 1.3e-29 101.8 8.0 1.0 1 0 0 1 1 1 1 Ribosomal L40e family NTP_transf_2 PF01909.23 EKE37989.1 - 6.7e-07 29.5 0.0 1.2e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 EKE37989.1 - 2.2e-05 24.3 0.0 4.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Nrap protein PAP/OAS-like domain PAP_central PF04928.17 EKE37989.1 - 0.00061 18.8 2.8 0.025 13.5 0.1 3.2 1 1 1 2 2 2 2 Poly(A) polymerase central domain DUF4269 PF14091.6 EKE37989.1 - 0.042 14.1 0.1 0.07 13.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4269) Sulfotransfer_3 PF13469.6 EKE37990.1 - 9e-16 58.9 1.7 1.7e-15 58.0 0.5 2.1 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EKE37990.1 - 0.00014 21.4 0.5 0.00074 19.1 0.5 2.1 1 1 0 1 1 1 1 Sulfotransferase domain dUTPase PF00692.19 EKE37990.1 - 0.082 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 dUTPase Chlamy_scaf PF09675.10 EKE37990.1 - 0.14 12.5 0.4 0.49 10.8 0.0 2.1 2 0 0 2 2 2 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) Thioredoxin_8 PF13905.6 EKE37991.1 - 0.049 13.9 1.0 0.065 13.6 0.9 1.3 1 1 0 1 1 1 0 Thioredoxin-like DUF3780 PF12635.7 EKE37991.1 - 0.082 12.7 0.2 0.091 12.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3780) Mistic PF11458.8 EKE37992.1 - 0.02 14.9 3.4 0.02 14.9 3.4 2.4 3 0 0 3 3 3 0 Membrane-integrating protein Mistic Phage_Gp19 PF09355.10 EKE37992.1 - 0.78 10.2 4.9 0.16 12.4 0.7 2.0 2 0 0 2 2 2 0 Phage protein Gp19/Gp15/Gp42 KxDL PF10241.9 EKE37992.1 - 7.8 6.8 19.5 0.5 10.7 1.0 3.7 3 1 1 4 4 4 0 Uncharacterized conserved protein Pkinase PF00069.25 EKE37993.1 - 4e-70 236.2 0.0 5.5e-70 235.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE37993.1 - 3e-55 187.3 0.0 4.1e-55 186.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE37993.1 - 2.8e-07 29.7 0.0 5.4e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKE37993.1 - 3.5e-05 23.3 0.0 0.0079 15.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like DUF1400 PF07176.11 EKE37993.1 - 0.017 15.4 0.1 1.6 9.0 0.1 2.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1400) Haspin_kinase PF12330.8 EKE37993.1 - 0.089 11.7 0.4 0.3 10.0 0.4 1.8 1 1 0 1 1 1 0 Haspin like kinase domain PBD PF00786.28 EKE37993.1 - 0.092 13.1 0.6 0.28 11.6 0.0 2.2 2 0 0 2 2 2 0 P21-Rho-binding domain Ras PF00071.22 EKE37995.1 - 1.2e-15 57.5 0.6 1.5e-15 57.2 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37995.1 - 1.9e-09 37.7 0.1 3.2e-09 37.0 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase CarD_CdnL_TRCF PF02559.16 EKE37995.1 - 0.022 15.4 0.2 0.037 14.7 0.2 1.5 1 1 0 1 1 1 0 CarD-like/TRCF domain Surp PF01805.20 EKE37996.1 - 0.23 11.5 2.8 0.35 10.9 0.4 2.5 2 1 0 2 2 2 0 Surp module HTH_7 PF02796.15 EKE37997.1 - 2.6e-06 27.4 1.7 7.7e-06 25.9 1.7 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_40 PF14493.6 EKE37997.1 - 9.6e-05 22.8 1.2 0.00018 21.9 0.2 2.0 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 EKE37997.1 - 0.0017 18.3 0.0 0.0038 17.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 EKE37997.1 - 0.004 16.9 0.1 0.017 14.9 0.0 2.0 2 1 1 3 3 3 1 Homeodomain-like domain Terminase_5 PF06056.12 EKE37997.1 - 0.0051 16.7 0.1 0.0094 15.8 0.1 1.4 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) Arg_repressor PF01316.21 EKE37997.1 - 0.0099 15.6 0.0 0.028 14.2 0.0 1.8 1 0 0 1 1 1 1 Arginine repressor, DNA binding domain KORA PF16509.5 EKE37997.1 - 0.011 15.9 0.2 0.027 14.7 0.0 1.7 2 0 0 2 2 2 0 TrfB plasmid transcriptional repressor Sigma70_r4_2 PF08281.12 EKE37997.1 - 0.014 15.1 0.2 0.033 13.9 0.2 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_11 PF08279.12 EKE37997.1 - 0.02 14.8 0.2 0.23 11.4 0.0 2.6 3 0 0 3 3 3 0 HTH domain Sigma70_ECF PF07638.11 EKE37997.1 - 0.038 13.9 0.1 0.075 12.9 0.1 1.5 1 0 0 1 1 1 0 ECF sigma factor HTH_28 PF13518.6 EKE37997.1 - 0.071 13.3 0.2 0.18 12.0 0.1 1.8 1 1 0 1 1 1 0 Helix-turn-helix domain Ras PF00071.22 EKE37998.1 - 4.7e-51 172.6 0.1 5.4e-51 172.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE37998.1 - 1.4e-17 64.0 0.1 2.9e-17 63.0 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE37998.1 - 7.5e-10 38.5 0.0 8.8e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE37998.1 - 8.2e-08 32.0 0.1 1.4e-07 31.2 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE37998.1 - 0.00017 21.6 1.1 0.0076 16.2 0.0 2.2 1 1 1 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EKE37998.1 - 0.0035 17.4 0.0 0.0061 16.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Forkhead PF00250.18 EKE37999.1 - 8e-05 22.8 0.4 0.00015 22.0 0.4 1.6 1 0 0 1 1 1 1 Forkhead domain DUF3914 PF13053.6 EKE38000.1 - 0.037 14.4 0.2 0.32 11.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3914) DUF4215 PF13948.6 EKE38001.1 - 0.0015 19.0 8.3 0.0015 19.0 8.3 2.5 2 1 1 3 3 3 1 Domain of unknown function (DUF4215) Furin-like_2 PF15913.5 EKE38001.1 - 0.012 15.7 1.3 0.026 14.7 1.3 1.6 1 0 0 1 1 1 0 Furin-like repeat, cysteine-rich TIL PF01826.17 EKE38001.1 - 0.18 12.0 4.0 0.36 11.1 4.0 1.5 1 1 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain WD40 PF00400.32 EKE38002.1 - 1.1e-36 124.2 26.4 3.2e-08 34.1 0.1 7.2 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE38002.1 - 3.2e-10 40.1 0.4 0.1 12.9 0.0 5.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EKE38002.1 - 0.0031 16.5 0.9 5.4 5.9 0.1 4.1 2 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 EKE38002.1 - 0.0062 14.9 0.1 0.17 10.1 0.1 2.8 1 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz PQ-loop PF04193.14 EKE38003.1 - 2e-16 59.5 10.7 1.3e-10 40.8 2.3 3.1 3 1 0 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.18 EKE38003.1 - 0.061 14.1 0.5 0.061 14.1 0.5 3.2 2 2 1 3 3 3 0 ER lumen protein retaining receptor Iron_permease PF04120.12 EKE38003.1 - 0.23 11.2 1.1 0.61 9.9 1.1 1.7 1 0 0 1 1 1 0 Low affinity iron permease MtN3_slv PF03083.16 EKE38003.1 - 3.9 7.6 18.6 0.047 13.7 2.7 2.8 3 1 0 3 3 3 0 Sugar efflux transporter for intercellular exchange DUF2207 PF09972.9 EKE38003.1 - 8.4 5.0 8.2 1 8.0 2.2 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Helicase_C_2 PF13307.6 EKE38006.1 - 2.1e-41 141.9 0.0 3.4e-41 141.3 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain HBB PF06777.11 EKE38006.1 - 5.8e-06 26.1 0.0 1.7e-05 24.6 0.0 1.8 1 1 0 1 1 1 1 Helical and beta-bridge domain DEAD_2 PF06733.15 EKE38007.1 - 0.0004 20.1 0.3 0.00049 19.8 0.3 1.1 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 EKE38008.1 - 0.0011 19.0 0.0 0.0014 18.7 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EKE38008.1 - 0.0075 16.6 0.1 0.014 15.7 0.1 1.4 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 EKE38008.1 - 0.039 13.5 0.6 0.052 13.1 0.3 1.3 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain DEAD_2 PF06733.15 EKE38008.1 - 0.041 13.5 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 DEAD_2 XRN_M PF17846.1 EKE38009.1 - 5.7e-109 365.0 13.5 9e-109 364.4 13.5 1.2 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EKE38009.1 - 7.5e-88 294.0 0.1 7.5e-88 294.0 0.1 1.9 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus zf-RING_2 PF13639.6 EKE38011.1 - 0.00013 22.2 21.8 0.0036 17.6 13.3 2.3 2 0 0 2 2 2 2 Ring finger domain Prok-RING_1 PF14446.6 EKE38011.1 - 0.00013 21.8 16.8 0.011 15.7 0.3 2.7 2 1 0 2 2 2 2 Prokaryotic RING finger family 1 zf-C3HC4_3 PF13920.6 EKE38011.1 - 0.00074 19.3 17.1 0.027 14.3 9.5 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) A2L_zn_ribbon PF08792.10 EKE38011.1 - 0.0039 16.9 4.4 0.0039 16.9 4.4 2.9 2 1 0 2 2 2 1 A2L zinc ribbon domain zf-RING_5 PF14634.6 EKE38011.1 - 0.0087 16.0 22.4 0.052 13.5 13.1 2.5 2 0 0 2 2 2 2 zinc-RING finger domain zinc-ribbons_6 PF07191.12 EKE38011.1 - 0.023 14.7 14.6 0.098 12.6 0.5 2.3 2 0 0 2 2 2 0 zinc-ribbons zf-C3HC4 PF00097.25 EKE38011.1 - 0.027 14.3 22.0 0.82 9.6 10.5 3.1 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_9 PF14369.6 EKE38011.1 - 0.071 13.4 3.7 0.071 13.4 3.7 3.3 3 2 0 3 3 2 0 zinc-ribbon PhnA_Zn_Ribbon PF08274.12 EKE38011.1 - 0.091 12.7 0.7 0.091 12.7 0.7 3.2 2 2 0 2 2 2 0 PhnA Zinc-Ribbon Prok-RING_4 PF14447.6 EKE38011.1 - 0.14 12.0 20.1 0.28 11.1 1.2 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EKE38011.1 - 0.36 10.7 21.8 0.42 10.5 12.5 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) HypA PF01155.19 EKE38011.1 - 1.4 9.0 10.6 0.15 12.1 0.7 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CBF PF03914.17 EKE38012.1 - 8.3e-24 84.5 0.0 8.3e-24 84.5 0.0 2.8 2 1 0 2 2 2 1 CBF/Mak21 family His_kinase PF06580.13 EKE38012.1 - 0.15 12.4 2.5 0.59 10.5 0.4 2.8 2 0 0 2 2 2 0 Histidine kinase Arm PF00514.23 EKE38013.1 - 0.021 14.9 0.0 11 6.2 0.0 3.0 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat XPG_I PF00867.18 EKE38014.1 - 0.062 13.7 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 XPG I-region Pkinase PF00069.25 EKE38015.1 - 7.8e-62 209.0 1.2 7.4e-56 189.4 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38015.1 - 6.1e-32 110.9 0.0 2.5e-31 108.9 0.0 2.0 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE38015.1 - 1.3e-05 24.2 0.0 2e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EKE38015.1 - 0.001 18.1 0.2 0.0017 17.4 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EKE38015.1 - 0.052 13.4 0.1 0.69 9.8 0.2 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 EKE38016.1 - 4.4e-47 160.6 0.2 1e-46 159.5 0.2 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38016.1 - 1.4e-40 139.2 0.3 2.3e-40 138.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE38016.1 - 9.1e-06 24.7 0.2 2.2e-05 23.4 0.2 1.6 1 0 0 1 1 1 1 Fungal protein kinase VSP PF03302.13 EKE38016.1 - 0.0025 16.7 114.4 0.018 13.9 35.5 4.7 1 1 2 3 3 3 2 Giardia variant-specific surface protein Kdo PF06293.14 EKE38016.1 - 0.073 12.4 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UPF0020 PF01170.18 EKE38018.1 - 4e-09 36.4 0.0 1.8e-08 34.3 0.0 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 EKE38018.1 - 0.00034 20.4 0.1 0.045 13.5 0.0 2.4 2 0 0 2 2 2 2 DNA methylase N6-adenineMlase PF10237.9 EKE38018.1 - 0.14 11.9 0.2 0.45 10.3 0.0 1.9 2 0 0 2 2 2 0 Probable N6-adenine methyltransferase Thioredoxin PF00085.20 EKE38019.1 - 1.2e-17 63.7 0.5 1.6e-10 40.9 0.1 2.2 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 EKE38019.1 - 7.5e-08 33.2 0.6 1.3e-06 29.3 0.1 2.7 2 1 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain SPRY PF00622.28 EKE38021.1 - 6.1e-07 29.6 0.1 1.1e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 SPRY domain BTB_2 PF02214.22 EKE38021.1 - 0.00026 21.3 0.3 0.0011 19.3 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain ASF1_hist_chap PF04729.13 EKE38021.1 - 0.048 13.6 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 ASF1 like histone chaperone LRR_4 PF12799.7 EKE38022.1 - 4.4 7.9 44.4 0.47 10.9 0.5 9.2 6 3 4 10 10 10 0 Leucine Rich repeats (2 copies) LIM PF00412.22 EKE38023.1 - 2.1e-06 27.8 9.8 4.3e-06 26.8 9.8 1.5 1 0 0 1 1 1 1 LIM domain Ribosomal_L11 PF00298.19 EKE38023.1 - 0.059 13.9 0.2 9.8 6.8 0.0 2.5 1 1 1 2 2 2 0 Ribosomal protein L11, RNA binding domain RRM_1 PF00076.22 EKE38024.1 - 2.5e-06 27.2 0.0 5.2e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AMP-binding PF00501.28 EKE38026.1 - 1.3e-29 103.1 0.0 1.9e-29 102.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Peptidase_C48 PF02902.19 EKE38027.1 - 1.2e-20 74.3 1.7 2.3e-20 73.4 1.7 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain PH_10 PF15411.6 EKE38027.1 - 0.32 11.2 5.3 8.9 6.6 0.1 3.1 3 0 0 3 3 3 0 Pleckstrin homology domain START PF01852.19 EKE38028.1 - 1.2e-25 90.1 1.0 1.7e-25 89.7 1.0 1.1 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 EKE38028.1 - 0.0064 16.5 0.7 0.037 14.0 0.7 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3074) IPI_T4 PF11634.8 EKE38028.1 - 0.082 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Nuclease inhibitor from bacteriophage T4 IPK PF03770.16 EKE38029.1 - 1.4e-35 123.0 1.0 1.8e-35 122.6 1.0 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase Plasmo_rep PF12135.8 EKE38030.1 - 0.18 11.4 1.1 11 5.6 0.1 2.8 2 0 0 2 2 2 0 Plasmodium repeat family DUF4386 PF14329.6 EKE38030.1 - 0.18 11.6 3.1 1.4 8.7 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4386) Oxidored_q5_N PF01059.17 EKE38030.1 - 4.3 7.5 10.9 0.36 10.9 4.7 2.4 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus 14-3-3 PF00244.20 EKE38032.1 - 2.4e-90 301.9 9.0 3e-90 301.6 9.0 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 EKE38032.1 - 0.0043 17.3 0.5 0.24 11.7 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat Arm PF00514.23 EKE38033.1 - 1.1e-07 31.6 0.5 0.38 10.9 0.0 6.5 6 1 1 7 7 7 2 Armadillo/beta-catenin-like repeat Mo25 PF08569.11 EKE38033.1 - 0.0016 17.9 2.0 0.0016 17.9 2.0 2.6 2 1 1 3 3 3 1 Mo25-like Arm_3 PF16186.5 EKE38033.1 - 0.13 11.9 1.2 0.88 9.2 0.0 2.4 2 0 0 2 2 2 0 Atypical Arm repeat SwrA PF17423.2 EKE38033.1 - 0.13 12.3 3.7 0.5 10.3 0.2 2.6 2 0 0 2 2 2 0 Swarming motility protein IBB PF01749.20 EKE38033.1 - 0.24 11.9 3.3 3.3 8.2 3.1 2.6 2 1 0 2 2 2 0 Importin beta binding domain DUF3361 PF11841.8 EKE38033.1 - 1.6 8.7 6.6 0.9 9.5 0.1 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF3361) SNARE PF05739.19 EKE38034.1 - 8.8e-07 28.8 0.3 8.8e-07 28.8 0.3 1.8 2 0 0 2 2 2 1 SNARE domain Prominin PF05478.11 EKE38034.1 - 0.0014 16.7 1.1 0.0015 16.6 1.1 1.1 1 0 0 1 1 1 1 Prominin UPF0122 PF04297.14 EKE38034.1 - 0.036 14.3 0.2 0.057 13.7 0.2 1.4 1 1 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like Sec20 PF03908.13 EKE38034.1 - 0.049 13.6 0.2 0.065 13.2 0.2 1.2 1 0 0 1 1 1 0 Sec20 CD225 PF04505.12 EKE38034.1 - 0.099 12.8 2.2 0.15 12.2 2.2 1.3 1 0 0 1 1 1 0 Interferon-induced transmembrane protein ANTH PF07651.16 EKE38035.1 - 7.7e-06 25.1 1.1 0.00012 21.2 0.1 2.6 1 1 1 2 2 2 1 ANTH domain ENTH PF01417.20 EKE38035.1 - 0.00084 19.4 2.2 0.0023 18.0 2.2 1.7 1 0 0 1 1 1 1 ENTH domain DUF4497 PF14924.6 EKE38035.1 - 0.033 14.7 0.1 0.14 12.6 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4497) PCNP PF15473.6 EKE38035.1 - 0.3 11.8 3.0 0.56 10.9 3.0 1.5 1 0 0 1 1 1 0 PEST, proteolytic signal-containing nuclear protein family DHHC PF01529.20 EKE38036.1 - 2.6e-24 85.8 18.6 2.6e-24 85.8 18.6 2.8 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF2318 PF10080.9 EKE38036.1 - 0.064 13.4 2.2 0.11 12.6 2.2 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) HAUS-augmin3 PF14932.6 EKE38037.1 - 0.0031 17.1 7.9 0.0031 17.1 7.9 3.1 2 1 1 3 3 2 1 HAUS augmin-like complex subunit 3 APG6_N PF17675.1 EKE38037.1 - 0.0037 17.8 13.0 0.0037 17.8 13.0 3.8 3 1 1 4 4 4 1 Apg6 coiled-coil region Mod_r PF07200.13 EKE38037.1 - 0.006 16.7 10.5 0.006 16.7 10.5 4.0 2 1 2 4 4 4 1 Modifier of rudimentary (Mod(r)) protein Laminin_II PF06009.12 EKE38037.1 - 0.044 13.8 26.1 0.37 10.8 0.0 4.6 2 1 2 4 4 4 0 Laminin Domain II MbeD_MobD PF04899.12 EKE38037.1 - 0.076 13.1 14.9 7.7 6.7 3.4 4.6 3 1 0 3 3 3 0 MbeD/MobD like Calc_CGRP_IAPP PF00214.19 EKE38037.1 - 0.19 12.1 0.1 0.19 12.1 0.1 2.3 2 1 1 3 3 3 0 Calcitonin / CGRP / IAPP family NPV_P10 PF05531.12 EKE38037.1 - 0.27 11.7 21.8 0.69 10.4 1.0 4.8 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein HsbA PF12296.8 EKE38037.1 - 0.4 11.1 4.6 5.2 7.5 1.4 2.7 2 1 0 2 2 2 0 Hydrophobic surface binding protein A Baculo_PEP_C PF04513.12 EKE38037.1 - 0.61 10.1 29.5 0.31 11.1 4.7 3.7 3 1 1 4 4 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 EKE38037.1 - 1.1 8.5 22.2 0.9 8.8 8.2 3.6 2 1 1 3 3 2 0 Domain of unknown function (DUF4407) FPP PF05911.11 EKE38037.1 - 1.4 7.0 34.4 0.12 10.5 26.6 2.3 2 1 0 2 2 2 0 Filament-like plant protein, long coiled-coil DUF948 PF06103.11 EKE38037.1 - 1.7 9.0 10.1 4.2 7.7 0.0 3.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF883 PF05957.13 EKE38037.1 - 1.9 9.2 8.2 0.13 12.8 1.4 2.7 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF883) CorA PF01544.18 EKE38037.1 - 3 7.1 16.0 4.1 6.6 12.9 2.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Tweety PF04906.13 EKE38037.1 - 4.8 5.7 11.2 3.1 6.4 7.0 2.3 2 0 0 2 2 2 0 Tweety YtxH PF12732.7 EKE38037.1 - 5.5 7.6 6.2 2.1e+02 2.5 4.9 4.0 3 2 0 3 3 3 0 YtxH-like protein DUF5082 PF16888.5 EKE38037.1 - 7.5 6.9 41.0 0.1 12.9 15.8 3.8 2 2 1 3 3 3 0 Domain of unknown function (DUF5082) Pkinase PF00069.25 EKE38038.1 - 6.5e-58 196.2 0.0 1.1e-57 195.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38038.1 - 1.3e-37 129.5 0.0 1.9e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EKE38038.1 - 0.0099 14.9 0.8 0.02 13.9 0.8 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EKE38038.1 - 0.02 14.2 0.0 0.12 11.7 0.0 2.2 3 0 0 3 3 3 0 Kinase-like APH PF01636.23 EKE38038.1 - 0.032 14.2 0.0 0.12 12.3 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 EKE38038.1 - 0.034 13.8 0.2 0.17 11.5 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EKE38038.1 - 0.066 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EKE38038.1 - 0.071 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Herpes_capsid PF06112.11 EKE38039.1 - 0.11 12.6 6.7 0.14 12.2 6.7 1.1 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein PRKCSH-like PF12999.7 EKE38040.1 - 1.1e-27 97.0 14.9 1.1e-27 97.0 14.9 2.9 1 1 1 3 3 3 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EKE38040.1 - 4.1e-11 42.8 6.8 4.1e-11 42.8 6.8 2.9 2 2 2 4 4 4 1 Glucosidase II beta subunit-like protein Ldl_recept_a PF00057.18 EKE38040.1 - 0.0036 17.5 17.9 0.053 13.8 1.8 2.7 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Fzo_mitofusin PF04799.13 EKE38040.1 - 6.4 6.3 24.0 3.6 7.1 11.0 3.0 1 1 1 3 3 3 0 fzo-like conserved region Fmp27_WPPW PF10359.9 EKE38040.1 - 6.7 5.4 34.8 0.052 12.4 14.8 2.2 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain PNP_UDP_1 PF01048.20 EKE38041.1 - 4.2e-07 29.4 0.0 5.1e-07 29.2 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily PNP_UDP_1 PF01048.20 EKE38042.1 - 1e-14 54.4 0.2 1.1e-14 54.2 0.2 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Piezo_RRas_bdg PF12166.8 EKE38043.1 - 4.9e-92 309.4 7.0 4.9e-92 309.4 7.0 3.4 4 0 0 4 4 4 1 Piezo non-specific cation channel, R-Ras-binding domain Cadherin_3 PF16184.5 EKE38043.1 - 0.12 12.4 0.8 0.29 11.2 0.8 1.6 1 0 0 1 1 1 0 Cadherin-like NLPC_P60 PF00877.19 EKE38043.1 - 0.17 11.9 0.5 0.49 10.4 0.1 2.0 2 0 0 2 2 2 0 NlpC/P60 family Nse4_C PF08743.10 EKE38045.1 - 1.5e-23 82.9 1.4 3e-23 81.9 1.4 1.6 1 0 0 1 1 1 1 Nse4 C-terminal AAA_5 PF07728.14 EKE38048.1 - 0.019 14.9 0.2 0.024 14.6 0.2 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) 23S_rRNA_IVP PF05635.11 EKE38048.1 - 0.046 14.0 3.9 0.049 13.9 2.7 1.6 1 1 0 1 1 1 0 23S rRNA-intervening sequence protein HSCB_C PF07743.13 EKE38048.1 - 0.13 12.8 1.4 0.68 10.5 1.4 2.1 1 1 0 1 1 1 0 HSCB C-terminal oligomerisation domain TLD PF07534.16 EKE38049.1 - 0.00072 19.8 1.4 0.0011 19.2 1.4 1.3 1 0 0 1 1 1 1 TLD Retrotran_gag_2 PF14223.6 EKE38049.1 - 0.023 14.3 1.2 0.041 13.5 1.2 1.3 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type ATG16 PF08614.11 EKE38049.1 - 0.033 14.4 4.2 0.047 13.9 4.2 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) USP8_interact PF08941.10 EKE38049.1 - 0.3 10.9 2.0 0.47 10.2 2.0 1.3 1 0 0 1 1 1 0 USP8 interacting DUF5517 PF17639.2 EKE38049.1 - 1.1 9.7 5.2 12 6.3 3.0 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5517) Atg14 PF10186.9 EKE38049.1 - 1.6 7.7 7.4 2.1 7.4 7.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NHL PF01436.21 EKE38052.1 - 3.2e-08 33.2 5.8 0.69 10.1 0.0 6.6 5 2 0 5 5 5 3 NHL repeat zf-B_box PF00643.24 EKE38052.1 - 5.6e-08 32.8 7.8 5.6e-08 32.8 7.8 4.6 3 1 1 4 4 4 2 B-box zinc finger zf-RING_UBOX PF13445.6 EKE38052.1 - 5.8e-05 23.0 5.8 5.8e-05 23.0 5.8 2.8 2 0 0 2 2 2 1 RING-type zinc-finger DUF5128 PF17170.4 EKE38052.1 - 0.0014 17.9 4.0 0.4 9.8 0.0 2.9 1 1 1 2 2 2 2 6-bladed beta-propeller TolB_like PF15869.5 EKE38052.1 - 0.002 17.4 0.1 0.0046 16.2 0.1 1.5 1 1 0 1 1 1 1 TolB-like 6-blade propeller-like zf-C3HC4 PF00097.25 EKE38052.1 - 0.0031 17.3 11.3 0.0031 17.3 11.3 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE38052.1 - 0.0084 16.4 12.1 0.0084 16.4 12.1 3.3 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 EKE38052.1 - 0.0087 16.0 11.0 0.0087 16.0 11.0 3.2 2 1 0 2 2 2 1 zinc-RING finger domain EcoEI_R_C PF08463.10 EKE38053.1 - 0.0047 17.1 3.2 0.0052 16.9 3.2 1.1 1 0 0 1 1 1 1 EcoEI R protein C-terminal DUF382 PF04037.13 EKE38053.1 - 0.067 13.3 3.6 0.09 12.9 3.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF382) MCPVI PF02993.14 EKE38053.1 - 0.22 11.3 2.0 0.27 11.0 2.0 1.0 1 0 0 1 1 1 0 Minor capsid protein VI PP2C PF00481.21 EKE38054.1 - 1.5e-27 96.9 0.2 2.8e-27 96.0 0.2 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE38054.1 - 1.4e-06 28.1 0.0 2.1e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C NAC PF01849.18 EKE38055.1 - 0.00083 19.3 0.2 0.0018 18.2 0.2 1.6 1 0 0 1 1 1 1 NAC domain FlxA PF14282.6 EKE38055.1 - 0.75 9.8 10.5 2.5 8.2 9.4 2.1 2 0 0 2 2 2 0 FlxA-like protein Ku_C PF03730.14 EKE38055.1 - 5 7.9 13.0 1.5 9.5 9.5 2.0 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm Methyltr_RsmB-F PF01189.17 EKE38056.1 - 7.8e-75 250.9 0.0 2e-74 249.6 0.0 1.7 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EKE38056.1 - 8.6e-11 42.2 0.6 2.9e-10 40.5 0.0 2.2 3 0 0 3 3 3 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltransf_25 PF13649.6 EKE38056.1 - 0.0038 17.9 0.0 0.011 16.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EKE38056.1 - 0.0071 16.5 0.1 0.0071 16.5 0.1 2.9 1 1 2 3 3 3 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 EKE38056.1 - 0.0072 16.1 1.0 0.017 14.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EKE38056.1 - 0.0081 15.5 0.0 0.023 14.0 0.0 1.7 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EKE38056.1 - 0.043 13.6 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) BP28CT PF08146.12 EKE38057.1 - 1.3e-15 57.6 4.3 2e-15 57.0 0.4 3.4 3 0 0 3 3 3 1 BP28CT (NUC211) domain HEAT_2 PF13646.6 EKE38057.1 - 0.085 13.3 0.0 0.34 11.3 0.0 2.1 1 0 0 1 1 1 0 HEAT repeats Fib_alpha PF08702.10 EKE38058.1 - 0.01 16.0 1.0 0.012 15.8 1.0 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FlgN PF05130.12 EKE38058.1 - 0.026 15.0 1.9 0.037 14.6 1.8 1.4 1 1 0 1 1 1 0 FlgN protein DUF3201 PF11447.8 EKE38058.1 - 0.032 13.7 0.3 0.041 13.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3201) Ntox11 PF15521.6 EKE38059.1 - 0.0093 15.6 1.0 1.6 8.3 0.1 3.0 3 0 0 3 3 3 2 Novel toxin 11 Gemini_AL1 PF00799.20 EKE38059.1 - 0.01 16.2 0.2 0.029 14.7 0.2 1.8 1 0 0 1 1 1 0 Geminivirus Rep catalytic domain zf-C3HC4_3 PF13920.6 EKE38061.1 - 1.7e-05 24.6 11.2 1.7e-05 24.6 11.2 3.8 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C2H2_4 PF13894.6 EKE38061.1 - 0.0021 18.7 4.7 0.02 15.7 0.2 7.5 8 2 0 8 8 8 2 C2H2-type zinc finger zf-RING_2 PF13639.6 EKE38061.1 - 0.021 15.1 11.2 0.021 15.1 11.2 3.6 3 0 0 3 3 3 0 Ring finger domain zf-C2H2 PF00096.26 EKE38061.1 - 0.022 15.2 32.2 0.66 10.5 0.3 7.1 6 1 0 6 6 6 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EKE38061.1 - 0.41 11.0 27.0 0.45 10.9 7.7 4.7 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) Rap_GAP PF02145.15 EKE38063.1 - 6.3e-46 156.3 1.3 1.4e-45 155.2 1.3 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Ank_4 PF13637.6 EKE38063.1 - 7.2e-23 80.7 0.4 1.8e-06 28.4 0.0 4.5 1 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKE38063.1 - 9.2e-23 80.6 4.5 1.8e-08 34.9 0.6 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKE38063.1 - 1.8e-20 70.8 0.5 0.021 15.3 0.0 6.0 5 0 0 5 5 5 5 Ankyrin repeat Ank PF00023.30 EKE38063.1 - 4.3e-20 71.2 0.1 0.0068 16.8 0.0 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 EKE38063.1 - 7.3e-15 54.9 1.9 0.00011 22.4 0.1 3.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) DUF4795 PF16043.5 EKE38063.1 - 0.28 10.8 6.9 0.51 9.9 0.1 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4795) Rho_Binding PF08912.11 EKE38063.1 - 2.7 8.9 7.6 13 6.6 0.5 3.0 3 0 0 3 3 3 0 Rho Binding Cluap1 PF10234.9 EKE38064.1 - 0.026 13.9 0.9 0.026 13.9 0.9 1.8 1 1 1 2 2 2 0 Clusterin-associated protein-1 DUF4134 PF13572.6 EKE38064.1 - 0.14 12.4 0.1 0.28 11.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4134) HTH_3 PF01381.22 EKE38065.1 - 0.085 12.9 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix Cir_N PF10197.9 EKE38067.1 - 0.00042 20.4 7.0 0.00042 20.4 7.0 3.3 2 1 1 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR Chordopox_A13L PF05961.11 EKE38067.1 - 0.06 13.6 1.7 0.06 13.6 1.7 2.2 2 1 0 2 2 2 0 Chordopoxvirus A13L protein GST_C PF00043.25 EKE38067.1 - 0.85 9.9 6.8 0.45 10.8 0.5 2.2 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain PRP1_N PF06424.12 EKE38067.1 - 2.6 8.4 12.8 0.91 9.9 4.5 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Rap_GAP PF02145.15 EKE38068.1 - 5.1e-55 185.9 1.2 5.1e-55 185.9 1.2 2.4 2 0 0 2 2 2 1 Rap/ran-GAP C2 PF00168.30 EKE38068.1 - 2.4e-05 24.6 1.2 0.0019 18.5 0.1 2.8 2 0 0 2 2 2 1 C2 domain FBA_3 PF08268.12 EKE38068.1 - 0.037 14.0 2.4 0.12 12.3 2.4 1.9 1 0 0 1 1 1 0 F-box associated domain ISP3_C PF18045.1 EKE38068.1 - 0.064 13.1 0.2 0.22 11.4 0.2 1.9 1 0 0 1 1 1 0 ISP3 C-terminal ATP_bind_3 PF01171.20 EKE38069.1 - 1.1e-17 64.4 0.0 1.9e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 EKE38069.1 - 2.8e-11 42.7 4.8 2.8e-11 42.7 4.8 3.0 4 0 0 4 4 4 1 Zinc-ribbon PAPS_reduct PF01507.19 EKE38069.1 - 0.022 14.8 0.0 0.063 13.3 0.0 1.8 1 1 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family NAD_synthase PF02540.17 EKE38069.1 - 0.062 12.4 0.0 0.1 11.7 0.0 1.5 1 1 0 1 1 1 0 NAD synthase zf-CHCC PF10276.9 EKE38069.1 - 8.5 6.5 8.1 6.2 7.0 0.1 3.8 4 0 0 4 4 4 0 Zinc-finger domain Apyrase PF06079.11 EKE38072.1 - 2.8e-92 309.0 7.2 3.3e-92 308.8 7.2 1.0 1 0 0 1 1 1 1 Apyrase DUF981 PF06168.11 EKE38073.1 - 3.5e-05 23.8 5.7 7.6e-05 22.7 5.7 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF981) TauE PF01925.19 EKE38073.1 - 0.00014 21.6 3.2 0.00036 20.2 3.5 1.5 1 1 1 2 2 2 1 Sulfite exporter TauE/SafE TssN PF17555.2 EKE38073.1 - 0.00022 20.7 9.1 0.00022 20.7 9.1 1.9 2 0 0 2 2 2 1 Type VI secretion system, TssN DUF2306 PF10067.9 EKE38073.1 - 0.00075 19.7 0.9 0.0014 18.8 0.9 1.4 1 0 0 1 1 1 1 Predicted membrane protein (DUF2306) Tetraspanin PF00335.20 EKE38073.1 - 0.0017 18.1 22.7 0.017 14.9 23.1 2.3 1 1 1 2 2 2 1 Tetraspanin family DUF5090 PF17009.5 EKE38073.1 - 0.12 12.3 18.5 0.45 10.5 11.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5090) CD20 PF04103.15 EKE38073.1 - 0.29 11.2 13.8 1.1 9.3 13.9 1.8 1 1 0 1 1 1 0 CD20-like family ETRAMP PF09716.10 EKE38073.1 - 1 9.5 7.5 0.28 11.2 0.5 2.9 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) DUF2070 PF09843.9 EKE38073.1 - 5.3 5.2 10.6 7.2 4.8 10.6 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) RasGEF PF00617.19 EKE38074.1 - 1.7e-19 70.7 0.1 4.7e-19 69.3 0.1 1.8 1 0 0 1 1 1 1 RasGEF domain UBA_3 PF09288.10 EKE38074.1 - 0.1 12.4 0.0 1.4 8.7 0.1 2.8 3 0 0 3 3 3 0 Fungal ubiquitin-associated domain Abhydrolase_1 PF00561.20 EKE38075.1 - 0.00029 20.6 0.0 0.00056 19.6 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF1057 PF06342.12 EKE38075.1 - 0.024 13.7 0.0 0.041 12.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_6 PF12697.7 EKE38075.1 - 0.051 14.2 0.0 0.079 13.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 EKE38075.1 - 0.14 12.2 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Myotub-related PF06602.14 EKE38076.1 - 1.2e-108 363.2 0.5 1.2e-108 363.2 0.5 1.8 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain PX PF00787.24 EKE38076.1 - 0.31 11.0 3.3 0.19 11.7 0.7 2.1 2 0 0 2 2 2 0 PX domain Ocular_alb PF02101.15 EKE38077.1 - 0.0039 16.2 6.7 0.0047 15.9 6.7 1.0 1 0 0 1 1 1 1 Ocular albinism type 1 protein DUF3488 PF11992.8 EKE38077.1 - 0.069 12.1 7.0 0.08 11.9 7.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) DUF2892 PF11127.8 EKE38077.1 - 0.094 12.8 0.2 0.094 12.8 0.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2892) PRA1 PF03208.19 EKE38077.1 - 4.2 7.0 16.5 0.82 9.3 11.4 1.9 2 0 0 2 2 2 0 PRA1 family protein DHHC PF01529.20 EKE38077.1 - 5.6 7.1 17.7 2.7 8.1 7.2 2.3 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF4064 PF13273.6 EKE38077.1 - 9.8 6.5 24.1 3.9 7.8 10.8 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) zf-C2HCIx2C PF10782.9 EKE38078.1 - 0.012 15.5 1.3 0.052 13.5 1.3 2.1 1 0 0 1 1 1 0 Zinc-finger XisI PF08869.11 EKE38078.1 - 6.9 7.1 7.6 2.2 8.6 0.7 3.0 3 1 0 3 3 3 0 XisI protein PUA PF01472.20 EKE38079.1 - 4.3e-14 52.2 0.3 6.1e-14 51.7 0.3 1.2 1 0 0 1 1 1 1 PUA domain Pre-PUA PF17832.1 EKE38079.1 - 3.4e-13 50.1 0.5 4.9e-13 49.6 0.5 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain DUF1947 PF09183.10 EKE38079.1 - 0.011 16.0 0.1 0.038 14.3 0.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1947) Cullin PF00888.22 EKE38080.1 - 2.8e-31 108.8 35.8 2.8e-31 108.8 35.8 1.4 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EKE38080.1 - 5.5e-16 58.4 3.8 5.5e-16 58.4 3.8 4.5 5 1 1 6 6 6 1 Cullin protein neddylation domain Uricase PF01014.18 EKE38080.1 - 0.022 15.0 0.0 0.63 10.3 0.0 3.0 3 1 0 3 3 3 0 Uricase zf-CHC2 PF01807.20 EKE38080.1 - 0.31 10.9 8.1 1.5 8.7 0.2 3.6 4 0 0 4 4 4 0 CHC2 zinc finger Cation_ATPase_C PF00689.21 EKE38081.1 - 6.2e-32 110.8 2.5 7.6e-32 110.5 2.5 1.1 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus DUF3531 PF12049.8 EKE38081.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3531) C2 PF00168.30 EKE38083.1 - 1.3e-21 76.8 0.1 8.4e-16 58.1 0.1 3.3 3 0 0 3 3 3 3 C2 domain B9-C2 PF07162.11 EKE38083.1 - 0.051 13.8 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Ciliary basal body-associated, B9 protein SGT1 PF07093.11 EKE38084.1 - 2.1e-11 43.0 0.4 2.1e-11 43.0 0.4 1.9 2 2 0 2 2 2 1 SGT1 protein Smg4_UPF3 PF03467.15 EKE38084.1 - 0.12 12.4 0.5 0.27 11.3 0.5 1.5 1 0 0 1 1 1 0 Smg-4/UPF3 family Peptidase_M50 PF02163.22 EKE38085.1 - 1.4 8.2 5.7 0.17 11.2 1.0 1.8 2 0 0 2 2 2 0 Peptidase family M50 Ribosomal_S25 PF03297.15 EKE38086.1 - 1.9e-35 121.1 4.7 1.9e-35 121.1 4.7 2.1 1 1 1 2 2 2 1 S25 ribosomal protein AIPR PF10592.9 EKE38086.1 - 0.021 14.5 0.4 0.024 14.3 0.4 1.1 1 0 0 1 1 1 0 AIPR protein ArfGap PF01412.18 EKE38087.1 - 1.7e-33 115.1 0.9 1.7e-33 115.1 0.9 1.6 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Phage_GP20 PF06810.11 EKE38088.1 - 0.0035 17.1 5.5 0.047 13.5 1.2 2.1 1 1 1 2 2 2 2 Phage minor structural protein GP20 NB-LRR PF12061.8 EKE38088.1 - 0.015 14.6 0.9 0.017 14.4 0.9 1.1 1 0 0 1 1 1 0 Late blight resistance protein R1 TPD52 PF04201.15 EKE38088.1 - 0.019 14.6 0.5 0.019 14.6 0.5 1.4 2 0 0 2 2 2 0 Tumour protein D52 family DUF4549 PF15082.6 EKE38088.1 - 0.02 14.7 1.7 0.021 14.6 1.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4549) Sec2p PF06428.11 EKE38088.1 - 0.022 14.7 2.4 0.022 14.7 2.4 1.5 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p CorA PF01544.18 EKE38088.1 - 0.05 12.9 2.3 0.33 10.2 0.6 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF1539 PF07560.11 EKE38088.1 - 0.28 11.3 3.7 2.5 8.2 0.0 2.2 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1539) Ank_2 PF12796.7 EKE38089.1 - 1e-18 67.7 9.9 1.4e-10 41.6 0.8 3.4 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) RabGAP-TBC PF00566.18 EKE38089.1 - 2.1e-14 53.7 3.2 8.3e-14 51.7 3.2 2.1 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Ank_5 PF13857.6 EKE38089.1 - 2.7e-13 49.9 0.1 2.2e-05 24.6 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EKE38089.1 - 9.7e-13 48.4 0.5 0.006 17.1 0.1 4.5 4 0 0 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE38089.1 - 2.4e-10 39.7 0.8 0.0083 16.6 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EKE38089.1 - 8.3e-10 38.7 0.1 0.00011 22.5 0.0 3.2 2 1 0 2 2 2 2 Ankyrin repeat RNA_pol_Rpb4 PF03874.16 EKE38089.1 - 0.065 13.6 2.0 0.34 11.2 0.1 2.9 3 0 0 3 3 3 0 RNA polymerase Rpb4 BRCT PF00533.26 EKE38090.1 - 3.9e-09 36.7 11.4 3.7e-05 24.0 0.2 3.7 4 0 0 4 4 4 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EKE38090.1 - 2.1e-08 34.5 9.3 1.9e-06 28.2 0.0 3.3 2 1 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EKE38090.1 - 1.3e-05 25.0 0.1 1.3e-05 25.0 0.1 4.3 3 2 1 4 4 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EKE38090.1 - 0.052 13.6 0.1 0.42 10.7 0.0 2.6 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Dapper PF15268.6 EKE38090.1 - 0.17 10.7 28.7 0.2 10.5 28.7 1.1 1 0 0 1 1 1 0 Dapper SOBP PF15279.6 EKE38090.1 - 0.23 12.1 18.9 0.39 11.3 18.9 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein CDC27 PF09507.10 EKE38090.1 - 0.9 8.9 56.6 1.3 8.3 56.6 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Borrelia_P83 PF05262.11 EKE38090.1 - 1.1 7.7 41.5 1.7 7.1 41.5 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein Mitofilin PF09731.9 EKE38090.1 - 1.2 7.9 38.8 1.5 7.5 38.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein LAP1C PF05609.12 EKE38090.1 - 1.7 7.7 27.3 2.2 7.3 27.3 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4551 PF15087.6 EKE38090.1 - 6.7 5.4 22.5 10 4.8 22.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF966 PF06136.13 EKE38090.1 - 6.9 6.3 33.5 6.2 6.4 32.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF966) Ndc1_Nup PF09531.10 EKE38090.1 - 8.5 4.9 17.0 11 4.6 17.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Metallophos PF00149.28 EKE38091.1 - 2.2e-29 103.4 0.0 4.1e-29 102.6 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ribosomal_L27e PF01777.18 EKE38093.1 - 1.4e-24 86.2 5.5 2.1e-24 85.7 5.5 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EKE38093.1 - 3.2e-06 26.9 2.9 4.5e-06 26.4 1.8 1.9 2 0 0 2 2 2 1 KOW motif DUF5033 PF16436.5 EKE38093.1 - 0.0081 16.1 0.1 0.0094 15.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5033) Mon1 PF03164.14 EKE38094.1 - 3.6e-77 260.1 4.6 4.5e-77 259.8 4.6 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 RhoGEF PF00621.20 EKE38095.1 - 7.5e-12 45.8 4.7 7.5e-12 45.8 4.7 2.4 2 0 0 2 2 2 1 RhoGEF domain RGS PF00615.19 EKE38095.1 - 1.4e-11 44.6 7.1 2.5e-11 43.9 4.4 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain Neur PF00064.18 EKE38095.1 - 0.1 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Neuraminidase Ras PF00071.22 EKE38096.1 - 5.3e-43 146.4 0.0 6.4e-43 146.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38096.1 - 2.7e-31 108.3 0.0 4.5e-31 107.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38096.1 - 1.1e-13 51.0 0.0 1.4e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE38096.1 - 1.6e-05 24.4 0.0 2.1e-05 24.0 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EKE38096.1 - 0.00031 20.2 0.3 0.00068 19.1 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE38096.1 - 0.00043 20.2 0.1 0.12 12.3 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EKE38096.1 - 0.00063 19.3 0.0 0.03 13.8 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EKE38096.1 - 0.00099 19.4 0.0 0.0015 18.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain G-alpha PF00503.20 EKE38096.1 - 0.0011 18.2 2.0 0.033 13.3 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit ATP_bind_1 PF03029.17 EKE38096.1 - 0.002 18.0 0.2 0.082 12.7 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 EKE38096.1 - 0.0022 18.0 0.2 0.31 11.1 0.0 2.2 1 1 1 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EKE38096.1 - 0.0031 17.6 0.0 0.0052 16.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 EKE38096.1 - 0.0075 15.7 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein AAA_16 PF13191.6 EKE38096.1 - 0.012 16.0 0.0 0.031 14.7 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EKE38096.1 - 0.014 14.9 0.1 0.022 14.3 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EKE38096.1 - 0.074 12.8 0.5 0.2 11.3 0.5 2.0 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EKE38096.1 - 0.13 12.0 0.1 0.58 9.9 0.1 2.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 EKE38096.1 - 0.27 11.7 3.5 0.9 10.0 3.5 1.9 1 1 0 1 1 1 0 AAA domain Ribosomal_L30 PF00327.20 EKE38097.1 - 6.2e-20 70.8 1.9 1.6e-19 69.5 1.9 1.8 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 EKE38097.1 - 0.033 14.4 1.8 0.079 13.2 1.8 1.7 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain AAA PF00004.29 EKE38098.1 - 1.8e-48 164.3 1.0 5.1e-42 143.4 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EKE38098.1 - 7.2e-09 35.6 0.0 4.1e-05 23.4 0.0 2.9 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EKE38098.1 - 7.5e-09 35.1 0.0 4.6e-07 29.3 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EKE38098.1 - 8e-09 35.6 0.0 0.00055 19.9 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EKE38098.1 - 2.8e-08 34.3 0.0 0.00042 20.7 0.0 3.0 2 1 1 3 3 3 2 AAA ATPase domain AAA_14 PF13173.6 EKE38098.1 - 2.4e-07 30.9 4.3 0.0036 17.3 0.0 3.5 3 1 1 4 4 4 2 AAA domain AAA_2 PF07724.14 EKE38098.1 - 2.4e-07 31.0 0.0 7.9e-05 22.8 0.0 3.0 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) ABC_tran PF00005.27 EKE38098.1 - 1.7e-06 28.6 0.0 0.098 13.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter IstB_IS21 PF01695.17 EKE38098.1 - 2.4e-06 27.4 0.0 0.0022 17.8 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein TIP49 PF06068.13 EKE38098.1 - 1.5e-05 24.4 0.0 0.00023 20.5 0.0 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain ATPase_2 PF01637.18 EKE38098.1 - 2.4e-05 24.3 2.7 0.027 14.4 0.1 4.0 2 2 0 3 3 3 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EKE38098.1 - 4.1e-05 22.9 0.2 0.023 13.9 0.0 3.3 3 0 0 3 3 3 1 NB-ARC domain AAA_24 PF13479.6 EKE38098.1 - 4.1e-05 23.4 0.0 0.046 13.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EKE38098.1 - 0.00011 21.6 0.0 0.00062 19.2 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EKE38098.1 - 0.00015 22.1 0.0 0.04 14.3 0.0 3.1 3 0 0 3 3 2 1 RNA helicase TsaE PF02367.17 EKE38098.1 - 0.00016 21.7 0.0 0.032 14.2 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EKE38098.1 - 0.00023 21.2 0.0 0.93 9.4 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_33 PF13671.6 EKE38098.1 - 0.00024 21.3 0.0 0.043 14.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EKE38098.1 - 0.00033 20.2 0.0 0.068 12.7 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 EKE38098.1 - 0.00034 20.9 0.1 0.0098 16.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EKE38098.1 - 0.00034 21.2 0.0 0.0072 16.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EKE38098.1 - 0.00067 19.4 0.0 0.025 14.3 0.0 2.6 2 1 1 3 3 2 1 Sigma-54 interaction domain NTPase_1 PF03266.15 EKE38098.1 - 0.0013 18.7 0.3 2.7 7.9 0.0 3.2 2 1 1 3 3 3 1 NTPase AAA_3 PF07726.11 EKE38098.1 - 0.0014 18.5 0.0 0.44 10.4 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EKE38098.1 - 0.0014 18.5 0.1 2.3 8.1 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_17 PF13207.6 EKE38098.1 - 0.0018 18.7 0.0 0.032 14.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain DNA_pol3_delta2 PF13177.6 EKE38098.1 - 0.0024 17.7 0.1 1.5 8.6 0.0 2.9 3 0 0 3 3 3 1 DNA polymerase III, delta subunit TniB PF05621.11 EKE38098.1 - 0.0042 16.5 0.0 2.8 7.3 0.0 2.6 3 0 0 3 3 3 1 Bacterial TniB protein PhoH PF02562.16 EKE38098.1 - 0.0051 16.3 0.0 0.051 13.0 0.0 2.1 2 0 0 2 2 2 1 PhoH-like protein Cytidylate_kin PF02224.18 EKE38098.1 - 0.006 16.3 0.0 3.3 7.4 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase AAA_11 PF13086.6 EKE38098.1 - 0.0098 15.7 0.0 0.22 11.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EKE38098.1 - 0.011 16.0 0.0 0.14 12.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EKE38098.1 - 0.012 15.2 0.1 0.28 10.7 0.1 2.3 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 EKE38098.1 - 0.017 14.5 0.1 0.75 9.1 0.0 2.7 1 1 1 2 2 2 0 KaiC AAA_29 PF13555.6 EKE38098.1 - 0.019 14.7 1.4 5.7 6.8 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain ResIII PF04851.15 EKE38098.1 - 0.025 14.6 1.9 0.15 12.1 0.0 3.0 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EKE38098.1 - 0.044 13.5 0.0 0.14 11.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 EKE38098.1 - 0.051 13.4 0.0 0.31 10.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_19 PF13245.6 EKE38098.1 - 0.076 13.3 0.0 2 8.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EKE38098.1 - 0.08 12.0 0.1 0.25 10.4 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF2533 PF10752.9 EKE38098.1 - 0.093 13.2 0.0 0.86 10.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2533) HEAT PF02985.22 EKE38099.1 - 8.3e-15 53.6 2.7 0.043 14.1 0.0 9.0 10 0 0 10 10 10 3 HEAT repeat HEAT_2 PF13646.6 EKE38099.1 - 2.9e-08 34.0 0.0 0.03 14.7 0.0 6.4 5 3 2 7 7 7 3 HEAT repeats Vac14_Fab1_bd PF12755.7 EKE38099.1 - 4.6e-06 27.2 5.3 0.0042 17.6 0.1 4.7 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EKE38099.1 - 0.0017 18.4 4.7 0.28 11.2 0.1 4.3 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Tti2 PF10521.9 EKE38099.1 - 0.0063 16.1 1.9 1 8.9 0.1 3.4 4 0 0 4 4 4 2 Tti2 family RTP1_C1 PF10363.9 EKE38099.1 - 0.018 15.2 0.2 1.2 9.3 0.0 3.7 4 1 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Cullin_binding PF03556.15 EKE38100.1 - 6.9e-17 62.0 1.0 1.3e-16 61.1 1.0 1.4 1 0 0 1 1 1 1 Cullin binding Ndc1_Nup PF09531.10 EKE38100.1 - 0.083 11.6 2.5 0.095 11.4 2.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EKE38100.1 - 4.6 5.9 6.2 5.2 5.7 6.2 1.1 1 0 0 1 1 1 0 Presenilin NERD PF08378.11 EKE38101.1 - 0.04 14.4 0.2 0.056 13.9 0.2 1.5 1 1 0 1 1 1 0 Nuclease-related domain PIG-H PF10181.9 EKE38102.1 - 0.00013 21.8 0.4 0.00022 21.0 0.4 1.5 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component zf-CCCH PF00642.24 EKE38103.1 - 2.1e-10 40.2 3.5 2.1e-10 40.2 3.5 2.1 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_5 PF14634.6 EKE38103.1 - 2.1e-06 27.6 11.9 5.5e-06 26.2 11.9 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf_CCCH_4 PF18345.1 EKE38103.1 - 2.4e-05 24.2 5.4 2.4e-05 24.2 5.4 2.5 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 EKE38103.1 - 5.5e-05 22.9 3.1 5.5e-05 22.9 3.1 2.7 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EKE38103.1 - 0.079 13.5 2.8 0.079 13.5 2.8 3.0 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-RING_UBOX PF13445.6 EKE38103.1 - 0.23 11.5 10.0 0.079 13.0 3.1 2.9 2 1 1 3 3 3 0 RING-type zinc-finger zf-RING_2 PF13639.6 EKE38103.1 - 0.48 10.8 16.1 0.26 11.6 11.9 2.3 2 0 0 2 2 2 0 Ring finger domain Prok-RING_4 PF14447.6 EKE38103.1 - 0.7 9.8 13.8 19 5.2 0.4 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Ribosomal_L27A PF00828.19 EKE38104.1 - 8.8e-23 81.4 0.0 1.1e-22 81.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ham1p_like PF01725.16 EKE38105.1 - 1.3e-41 142.5 0.0 1.5e-41 142.4 0.0 1.0 1 0 0 1 1 1 1 Ham1 family BRK PF07533.16 EKE38105.1 - 0.086 12.5 0.3 0.16 11.6 0.3 1.4 1 0 0 1 1 1 0 BRK domain RhoGEF PF00621.20 EKE38107.1 - 4.9e-37 127.9 6.6 1.2e-36 126.7 6.6 1.7 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 EKE38107.1 - 2.6e-16 59.5 10.5 7e-16 58.1 10.5 1.8 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EKE38107.1 - 4.3e-07 30.4 1.0 8.8e-07 29.4 0.1 2.0 2 0 0 2 2 2 1 PH domain FYVE_2 PF02318.16 EKE38107.1 - 0.0037 17.5 7.2 0.015 15.5 7.2 2.1 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.5 EKE38107.1 - 0.48 10.2 3.9 2.4 7.9 0.1 2.8 2 1 1 3 3 3 0 Pleckstrin homology domain Sulfotransfer_3 PF13469.6 EKE38108.1 - 3.9e-17 63.4 0.0 9.4e-17 62.1 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EKE38108.1 - 1e-07 31.7 1.3 5.7e-07 29.3 1.3 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Pkinase_Tyr PF07714.17 EKE38109.1 - 5.1e-14 52.2 0.1 9e-14 51.4 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38109.1 - 9.7e-07 28.4 0.6 1.7e-06 27.6 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain EGF_2 PF07974.13 EKE38109.1 - 0.0012 19.2 12.4 0.0012 19.2 12.4 5.1 5 0 0 5 5 5 1 EGF-like domain Syndecan PF01034.20 EKE38109.1 - 1.3 9.0 5.6 7.8 6.5 3.4 2.4 2 0 0 2 2 2 0 Syndecan domain Potass_KdpF PF09604.10 EKE38109.1 - 1.4 8.9 5.9 0.22 11.6 1.5 1.9 2 0 0 2 2 2 0 F subunit of K+-transporting ATPase (Potass_KdpF) VSP PF03302.13 EKE38110.1 - 6.8 5.4 82.1 9.1 5.0 22.5 3.2 1 1 2 3 3 3 0 Giardia variant-specific surface protein Hid1 PF12722.7 EKE38111.1 - 0.00044 18.5 5.5 0.00044 18.5 5.5 2.2 1 1 1 2 2 2 1 High-temperature-induced dauer-formation protein DENN PF02141.21 EKE38112.1 - 2.2e-07 31.0 0.6 5e-07 29.8 0.4 1.7 2 0 0 2 2 2 1 DENN (AEX-3) domain PAP2_C PF14360.6 EKE38113.1 - 1.8e-11 44.4 11.2 1.8e-11 44.4 11.2 3.2 3 2 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EKE38113.1 - 8.1e-06 25.6 7.5 8.1e-06 25.6 7.5 2.4 2 1 0 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.6 EKE38113.1 - 4.4 6.9 18.2 1.2 8.7 13.2 2.4 2 1 0 2 2 2 0 PAP2 superfamily NB PF04159.13 EKE38114.1 - 0.044 13.8 0.0 0.082 12.9 0.0 1.4 1 0 0 1 1 1 0 NB glycoprotein Rtt106_N PF18215.1 EKE38114.1 - 0.062 13.1 1.4 0.14 12.0 0.5 1.9 2 0 0 2 2 2 0 Histone chaperone Rtt106 N-terminal domain Cation_efflux PF01545.21 EKE38115.1 - 5e-27 94.9 10.9 5.9e-27 94.7 10.9 1.1 1 0 0 1 1 1 1 Cation efflux family HAP PF03866.13 EKE38115.1 - 0.0047 17.0 1.1 0.01 15.9 1.1 1.5 1 0 0 1 1 1 1 Hydrophobic abundant protein (HAP) VPS13_C PF16909.5 EKE38117.1 - 0.0028 17.5 1.9 0.0044 16.8 1.9 1.3 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal Pkinase PF00069.25 EKE38118.1 - 1.8e-75 253.8 2.9 9.4e-53 179.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38118.1 - 2.9e-52 177.5 1.0 2.4e-29 102.4 0.0 3.0 3 0 0 3 3 3 3 Protein tyrosine kinase Kinase-like PF14531.6 EKE38118.1 - 4.1e-06 26.3 0.0 0.22 10.8 0.0 3.2 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 EKE38118.1 - 0.0017 17.2 0.0 0.0039 16.0 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Myosin-VI_CBD PF16521.5 EKE38118.1 - 0.025 14.5 0.2 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 Myosin VI cargo binding domain RRM_1 PF00076.22 EKE38119.1 - 1.8e-25 88.6 4.9 4.4e-19 68.1 0.2 3.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKE38119.1 - 0.00024 20.9 0.0 1.1 9.2 0.0 3.6 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 EKE38119.1 - 0.0026 17.6 6.8 0.13 12.0 0.1 3.4 3 1 1 4 4 4 2 Rrp7 RRM-like N-terminal domain RRM_7 PF16367.5 EKE38119.1 - 0.01 16.0 0.2 0.55 10.4 0.0 2.9 3 0 0 3 3 3 1 RNA recognition motif SET_assoc PF11767.8 EKE38119.1 - 0.016 14.8 0.2 0.2 11.3 0.1 2.7 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated RL PF17797.1 EKE38119.1 - 0.027 14.4 0.1 0.81 9.7 0.0 2.4 2 0 0 2 2 2 0 RL domain Ras PF00071.22 EKE38120.1 - 3e-53 179.7 0.6 3.6e-53 179.5 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38120.1 - 6.8e-18 65.0 0.0 1.4e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38120.1 - 5.7e-11 42.2 0.1 7e-11 41.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE38120.1 - 9.2e-07 28.6 0.1 1.7e-06 27.8 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE38120.1 - 0.00064 19.7 3.1 0.0022 17.9 0.2 2.2 1 1 1 2 2 2 1 RsgA GTPase Syntaxin-18_N PF10496.9 EKE38120.1 - 0.0063 16.7 1.3 0.023 14.9 1.4 1.8 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus AlaDh_PNT_C PF01262.21 EKE38120.1 - 0.11 11.8 0.1 0.14 11.4 0.1 1.4 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Rap_GAP PF02145.15 EKE38121.1 - 2.1e-58 197.0 0.2 6.3e-58 195.4 0.0 1.8 1 1 1 2 2 2 1 Rap/ran-GAP IL3 PF02059.15 EKE38121.1 - 0.026 14.6 0.1 0.083 13.0 0.1 1.8 1 0 0 1 1 1 0 Interleukin-3 DUF4576 PF15144.6 EKE38121.1 - 0.13 12.2 1.5 1.1 9.2 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4576) RhoGEF PF00621.20 EKE38122.1 - 8.5e-28 97.8 6.4 8.5e-28 97.8 6.4 4.1 3 1 1 4 4 4 1 RhoGEF domain ArfGap PF01412.18 EKE38122.1 - 1.3e-09 38.1 2.1 1.3e-09 38.1 2.1 4.5 5 2 0 5 5 5 1 Putative GTPase activating protein for Arf CH PF00307.31 EKE38122.1 - 9.2e-07 29.0 0.5 2.5e-05 24.4 0.2 3.2 2 0 0 2 2 2 1 Calponin homology (CH) domain PH PF00169.29 EKE38122.1 - 0.0024 18.3 6.7 0.64 10.6 0.0 4.0 4 0 0 4 4 4 2 PH domain HSP70 PF00012.20 EKE38123.1 - 2.5e-23 82.1 0.0 2.8e-23 81.9 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein GBR_NSP5 PF17580.2 EKE38123.1 - 0.085 12.7 0.6 0.14 12.0 0.6 1.2 1 0 0 1 1 1 0 Group B Rotavirus Non-structural protein 5 Mfa_like_2 PF15415.6 EKE38124.1 - 0.011 14.6 0.0 0.024 13.5 0.0 1.5 1 0 0 1 1 1 0 Fimbrillin-like DENN PF02141.21 EKE38125.1 - 3.8e-10 40.0 0.3 4.2e-10 39.9 0.3 1.0 1 0 0 1 1 1 1 DENN (AEX-3) domain Ras PF00071.22 EKE38126.1 - 1.7e-47 161.1 3.4 2.3e-47 160.6 3.4 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38126.1 - 5.2e-27 94.4 0.7 1e-26 93.5 0.7 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38126.1 - 5.1e-17 61.9 0.5 6.3e-17 61.6 0.5 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE38126.1 - 0.0075 15.7 1.6 0.012 15.1 0.2 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EKE38126.1 - 0.077 13.3 0.1 1.4 9.2 0.0 2.2 1 1 0 2 2 2 0 AAA domain Pneumovirus_M2 PF06436.11 EKE38126.1 - 0.14 11.6 1.5 0.21 11.1 1.5 1.3 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) Vac14_Fab1_bd PF12755.7 EKE38127.1 - 0.068 13.8 3.8 8 7.1 0.1 3.5 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Arm PF00514.23 EKE38127.1 - 0.12 12.5 2.2 15 5.8 0.0 3.6 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat FANCI_S2 PF14676.6 EKE38127.1 - 0.45 10.8 5.9 0.53 10.6 1.3 2.7 2 0 0 2 2 2 0 FANCI solenoid 2 Synaptobrevin PF00957.21 EKE38128.1 - 2.9e-08 33.4 1.8 4.9e-08 32.7 1.8 1.3 1 0 0 1 1 1 1 Synaptobrevin RST PF12174.8 EKE38128.1 - 0.052 13.5 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain TINF2_N PF14973.6 EKE38128.1 - 0.059 13.7 1.2 0.088 13.2 1.2 1.2 1 0 0 1 1 1 0 TERF1-interacting nuclear factor 2 N-terminus XRN_N PF03159.18 EKE38129.1 - 4e-93 311.3 0.0 4e-93 311.3 0.0 1.7 2 1 1 3 3 3 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EKE38129.1 - 6.8e-82 275.8 4.0 6.8e-82 275.8 4.0 1.6 2 0 0 2 2 2 1 Xrn1 helical domain RE_HindIII PF09518.10 EKE38129.1 - 0.64 9.2 7.5 0.11 11.8 3.0 2.0 2 0 0 2 2 2 0 HindIII restriction endonuclease dNK PF01712.19 EKE38130.1 - 2.2e-08 34.2 6.4 2.4e-06 27.6 0.4 2.1 1 1 1 2 2 2 2 Deoxynucleoside kinase AAA_18 PF13238.6 EKE38130.1 - 7.4e-06 26.5 0.5 0.00024 21.7 0.5 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKE38130.1 - 0.00072 19.8 0.0 0.0011 19.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EKE38130.1 - 0.0047 17.3 1.0 0.011 16.1 0.2 2.1 2 0 0 2 2 2 1 RNA helicase DUF815 PF05673.13 EKE38130.1 - 0.0057 15.8 0.1 0.013 14.7 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EKE38130.1 - 0.0078 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) TrwB_AAD_bind PF10412.9 EKE38130.1 - 0.0078 15.2 0.1 0.013 14.4 0.0 1.4 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.15 EKE38130.1 - 0.012 15.6 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.22 EKE38130.1 - 0.017 14.4 0.1 0.087 12.0 0.1 1.9 2 0 0 2 2 2 0 NB-ARC domain Glyco_hydro_71 PF03659.14 EKE38130.1 - 0.019 13.8 0.1 0.03 13.1 0.1 1.3 1 1 0 1 1 1 0 Glycosyl hydrolase family 71 AAA PF00004.29 EKE38130.1 - 0.021 15.3 0.1 0.044 14.2 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EKE38130.1 - 0.026 14.1 0.0 0.054 13.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Guanylate_kin PF00625.21 EKE38130.1 - 0.031 14.0 0.5 1.9 8.2 0.0 2.9 2 1 1 3 3 3 0 Guanylate kinase AAA_14 PF13173.6 EKE38130.1 - 0.038 14.0 1.3 0.15 12.1 0.1 2.2 2 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EKE38130.1 - 0.038 13.9 0.0 0.086 12.7 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Thymidylate_kin PF02223.17 EKE38130.1 - 0.041 13.6 0.3 9.3 5.9 0.1 2.3 2 0 0 2 2 2 0 Thymidylate kinase TsaE PF02367.17 EKE38130.1 - 0.047 13.7 0.1 0.088 12.8 0.1 1.6 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 EKE38130.1 - 0.079 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI CbiA PF01656.23 EKE38130.1 - 0.17 11.9 0.0 0.25 11.4 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain NACHT PF05729.12 EKE38130.1 - 0.19 11.7 0.2 1.5 8.7 0.0 2.1 2 0 0 2 2 2 0 NACHT domain MMR_HSR1 PF01926.23 EKE38130.1 - 0.19 11.8 0.3 0.4 10.8 0.3 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EKE38130.1 - 0.33 10.7 0.9 0.97 9.2 0.9 1.8 1 1 0 1 1 1 0 P-loop containing region of AAA domain SNRNP27 PF08648.12 EKE38132.1 - 1.2e-06 28.5 0.0 2.5e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins Spem1 PF15670.5 EKE38132.1 - 0.11 12.0 2.7 0.12 11.9 2.7 1.1 1 0 0 1 1 1 0 Spermatid maturation protein 1 Pkinase PF00069.25 EKE38133.1 - 1.5e-57 195.0 0.0 1.5e-45 155.7 0.0 3.3 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38133.1 - 2.3e-34 118.9 0.0 5e-25 88.3 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EKE38133.1 - 0.0016 17.8 0.0 0.042 13.1 0.0 3.0 3 1 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 EKE38133.1 - 0.16 10.7 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase AAA_23 PF13476.6 EKE38134.1 - 2.4e-14 54.3 14.2 2.4e-14 54.3 14.2 6.0 2 2 1 3 3 1 1 AAA domain AAA_15 PF13175.6 EKE38134.1 - 4.4e-09 36.5 12.3 4.4e-09 36.5 12.3 3.9 2 2 1 3 3 2 1 AAA ATPase domain AAA_21 PF13304.6 EKE38134.1 - 4.8e-06 26.6 16.5 0.00014 21.8 0.3 3.8 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EKE38134.1 - 7.5e-06 25.5 59.6 0.00012 21.6 59.6 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_13 PF13166.6 EKE38134.1 - 6.5e-05 21.8 20.2 6.5e-05 21.8 20.2 5.7 3 1 1 5 5 4 3 AAA domain AAA_29 PF13555.6 EKE38134.1 - 0.0029 17.3 0.0 0.0071 16.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_27 PF13514.6 EKE38134.1 - 0.023 14.3 0.0 0.023 14.3 0.0 5.2 5 1 1 6 6 6 0 AAA domain Prion PF00377.18 EKE38134.1 - 0.026 14.4 0.1 0.026 14.4 0.1 2.8 2 1 1 3 3 3 0 Prion/Doppel alpha-helical domain AAA_25 PF13481.6 EKE38134.1 - 0.074 12.6 0.1 0.56 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain QIL1 PF15884.5 EKE38134.1 - 0.093 13.3 1.1 0.53 10.9 1.1 2.4 1 0 0 1 1 1 0 MICOS complex subunit MIC13, QIL1 Retrotrans_gag PF03732.17 EKE38134.1 - 0.27 11.6 7.4 2.5 8.5 0.8 4.1 3 0 0 3 3 3 0 Retrotransposon gag protein MscS_porin PF12795.7 EKE38134.1 - 1.3 8.5 67.7 0.062 12.8 22.8 5.1 2 2 3 5 5 5 0 Mechanosensitive ion channel porin domain SAB PF04382.13 EKE38134.1 - 7.7 6.7 10.1 7 6.8 0.1 4.1 3 1 0 3 3 3 0 SAB domain DHR-2 PF06920.13 EKE38136.1 - 1.4e-19 70.2 6.9 5.2e-16 58.4 5.2 5.1 4 1 1 6 6 6 2 Dock homology region 2 DOCK-C2 PF14429.6 EKE38136.1 - 7e-07 29.3 1.1 1.4e-06 28.3 0.1 2.1 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins Lung_7-TM_R PF06814.13 EKE38137.1 - 5.6e-12 45.5 25.2 1.2e-11 44.4 25.2 1.5 1 1 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 EKE38137.1 - 8.4e-09 35.2 14.9 8.4e-09 35.2 14.9 2.6 2 1 0 3 3 3 1 Rhodopsin-like GPCR transmembrane domain Cation_ATPase_N PF00690.26 EKE38137.1 - 0.16 11.7 0.9 0.35 10.6 0.3 1.9 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus BRE1 PF08647.11 EKE38138.1 - 0.017 15.2 5.9 0.029 14.4 5.9 1.4 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF745 PF05335.13 EKE38138.1 - 0.13 12.0 2.3 0.14 11.8 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) CE2_N PF17996.1 EKE38138.1 - 0.2 11.6 1.3 0.27 11.2 1.3 1.2 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal TMPIT PF07851.13 EKE38138.1 - 0.42 9.8 4.5 0.45 9.7 4.5 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF16 PF01519.16 EKE38138.1 - 1.1 9.8 12.7 1.8 9.1 12.7 1.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF4559 PF15112.6 EKE38138.1 - 1.2 8.7 10.4 1.3 8.6 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) Snapin_Pallidin PF14712.6 EKE38138.1 - 2.6 8.5 10.3 4.8 7.7 0.4 2.1 1 1 1 2 2 2 0 Snapin/Pallidin DUF1664 PF07889.12 EKE38138.1 - 6.7 6.8 8.9 18 5.4 8.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Laminin_G_3 PF13385.6 EKE38139.1 - 6.2e-05 23.2 0.0 0.00011 22.4 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Arm PF00514.23 EKE38139.1 - 0.057 13.5 0.0 14 5.9 0.0 4.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Coatamer_beta_C PF07718.12 EKE38140.1 - 0.017 15.0 0.0 0.048 13.6 0.0 1.7 1 0 0 1 1 1 0 Coatomer beta C-terminal region Secretogranin_V PF05281.11 EKE38140.1 - 0.13 11.8 2.2 0.14 11.8 0.1 1.9 2 0 0 2 2 2 0 Neuroendocrine protein 7B2 precursor (Secretogranin V) NAP PF00956.18 EKE38141.1 - 4.7e-44 150.6 2.3 4.7e-44 150.6 2.3 1.4 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) ABC_tran_Xtn PF12848.7 EKE38141.1 - 0.052 13.6 1.1 0.11 12.6 1.1 1.5 1 0 0 1 1 1 0 ABC transporter AvrM-A PF18241.1 EKE38141.1 - 0.22 11.9 1.2 0.89 10.0 0.2 2.2 2 0 0 2 2 2 0 Flax-rust effector AvrM-A Pes-10 PF07149.11 EKE38141.1 - 0.77 8.8 11.3 1.4 7.9 11.3 1.3 1 0 0 1 1 1 0 Pes-10 DUF2457 PF10446.9 EKE38141.1 - 3.6 6.6 17.5 5.9 5.9 17.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 EKE38141.1 - 5.8 5.1 6.4 8.6 4.5 6.4 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EKE38141.1 - 9.8 5.5 8.4 18 4.6 8.4 1.4 1 0 0 1 1 1 0 SDA1 RasGEF PF00617.19 EKE38142.1 - 2.2e-44 151.8 0.9 3.8e-44 151.0 0.1 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EKE38142.1 - 2.1e-11 44.0 0.1 6.1e-11 42.5 0.0 1.8 1 1 0 1 1 1 1 RasGEF N-terminal motif LcrV PF04792.12 EKE38142.1 - 0.014 14.7 1.5 0.02 14.2 0.5 1.7 2 0 0 2 2 2 0 V antigen (LcrV) protein DUF4404 PF14357.6 EKE38142.1 - 0.018 15.6 0.3 0.05 14.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Dynamin_N PF00350.23 EKE38143.1 - 6e-10 39.4 0.4 6e-10 39.4 0.4 4.4 5 0 0 5 5 5 1 Dynamin family MMR_HSR1 PF01926.23 EKE38143.1 - 1.4e-05 25.1 0.1 0.00012 22.1 0.1 2.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ribosomal_L27e PF01777.18 EKE38143.1 - 0.0032 17.8 2.4 0.0032 17.8 2.4 3.6 4 0 0 4 4 4 1 Ribosomal L27e protein family YjeF_N PF03853.15 EKE38143.1 - 0.014 15.3 0.1 0.034 14.0 0.1 1.6 1 0 0 1 1 1 0 YjeF-related protein N-terminus Imm-NTF2 PF15655.6 EKE38143.1 - 0.026 14.8 1.1 0.026 14.8 1.1 3.2 3 1 0 3 3 3 0 NTF2 fold immunity protein PilJ PF13675.6 EKE38143.1 - 0.55 10.3 4.6 5.6 7.0 2.9 3.0 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Nre_C PF04895.12 EKE38143.1 - 0.9 9.5 0.0 0.9 9.5 0.0 3.4 3 0 0 3 3 3 0 Archaeal Nre, C-terminal NPV_P10 PF05531.12 EKE38143.1 - 1.2 9.6 8.1 17 5.9 0.6 3.9 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein LRR_5 PF13306.6 EKE38144.1 - 1.8e-57 192.8 29.5 2.2e-25 89.1 3.2 5.8 3 1 2 6 6 6 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE38144.1 - 1.4e-07 31.2 0.1 2.5 7.9 0.0 5.8 3 3 2 5 5 5 3 Leucine rich repeat Crystall PF00030.19 EKE38144.1 - 0.24 11.6 2.1 11 6.3 0.1 3.4 3 0 0 3 3 3 0 Beta/Gamma crystallin RdRP PF05183.12 EKE38145.1 - 1.5e-90 304.5 0.0 2.2e-90 304.0 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF1699 PF08004.11 EKE38145.1 - 0.03 14.0 0.0 0.12 12.1 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1699) Caudo_bapla16 PF16792.5 EKE38147.1 - 0.061 12.3 0.0 0.074 12.0 0.0 1.3 1 0 0 1 1 1 0 Phage tail base-plate attachment protein of Caudovirales ORF16 WAC_Acf1_DNA_bd PF10537.9 EKE38147.1 - 0.092 13.3 0.0 0.22 12.0 0.0 1.8 1 1 0 1 1 1 0 ATP-utilising chromatin assembly and remodelling N-terminal LRR_5 PF13306.6 EKE38148.1 - 1.3e-84 280.5 45.0 2e-32 111.8 8.8 3.9 1 1 3 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE38148.1 - 1.4e-21 76.0 3.5 4.9e-05 23.0 1.0 7.6 2 2 6 8 8 8 7 Leucine rich repeat Tetraspanin PF00335.20 EKE38149.1 - 0.00016 21.5 14.3 0.00079 19.2 14.3 1.9 1 1 0 1 1 1 1 Tetraspanin family Trp_oprn_chp PF09534.10 EKE38149.1 - 0.07 12.9 0.1 0.19 11.5 0.1 1.6 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) InaF-motif PF15018.6 EKE38149.1 - 0.1 12.5 0.2 0.1 12.5 0.2 2.1 2 0 0 2 2 2 0 TRP-interacting helix Phage_holin_3_6 PF07332.11 EKE38149.1 - 1.8 8.6 8.6 8.5 6.5 4.6 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III SdpI PF13630.6 EKE38149.1 - 9.2 6.5 9.5 21 5.4 0.5 2.3 2 0 0 2 2 2 0 SdpI/YhfL protein family HMG_box PF00505.19 EKE38150.1 - 1.8e-12 47.5 12.9 6.7e-11 42.4 2.2 2.6 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EKE38150.1 - 1.8e-11 44.5 2.8 1.8e-11 44.5 2.8 2.1 2 0 0 2 2 2 1 HMG-box domain Vac_ImportDeg PF09783.9 EKE38150.1 - 0.12 12.2 4.6 7.8 6.3 0.1 2.7 1 1 1 2 2 2 0 Vacuolar import and degradation protein Acetyltransf_1 PF00583.25 EKE38151.1 - 5.8e-19 68.5 0.1 7.1e-19 68.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EKE38151.1 - 3.8e-14 52.7 0.2 5.2e-14 52.3 0.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EKE38151.1 - 9.9e-14 51.5 0.3 1.3e-13 51.1 0.3 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EKE38151.1 - 3.5e-10 39.7 0.0 6.9e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EKE38151.1 - 5.8e-07 29.8 0.6 7.6e-07 29.4 0.6 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EKE38151.1 - 2.5e-06 28.2 0.0 3.3e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EKE38151.1 - 0.00038 20.5 0.0 0.00067 19.7 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.6 EKE38151.1 - 0.001 18.7 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Nudix_hydro PF18290.1 EKE38151.1 - 0.02 14.9 0.1 0.034 14.1 0.1 1.4 1 0 0 1 1 1 0 Nudix hydrolase domain F_actin_bund_C PF18060.1 EKE38152.1 - 2.2e-20 72.6 22.4 2.2e-20 72.6 22.4 4.3 2 2 1 3 3 3 1 F actin bundling C terminal UCH PF00443.29 EKE38153.1 - 2.9e-50 171.1 1.3 5.5e-50 170.3 1.3 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE38153.1 - 3.5e-10 40.0 12.3 4.3e-07 29.8 0.1 4.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EKE38153.1 - 1.5e-05 25.6 0.6 0.0002 21.9 0.1 3.1 2 0 0 2 2 2 1 DUSP domain Ribosomal_L40e PF01020.17 EKE38154.1 - 1.2e-29 102.0 8.0 1.3e-29 101.8 8.0 1.0 1 0 0 1 1 1 1 Ribosomal L40e family Peptidase_S74 PF13884.6 EKE38155.1 - 4.1e-15 55.8 0.1 8.3e-15 54.9 0.1 1.6 1 0 0 1 1 1 1 Chaperone of endosialidase DUF2207 PF09972.9 EKE38155.1 - 0.01 14.7 0.2 0.01 14.7 0.2 3.9 3 1 0 4 4 4 2 Predicted membrane protein (DUF2207) MCPVI PF02993.14 EKE38155.1 - 1.5 8.6 5.2 1.1 9.1 3.2 1.7 2 0 0 2 2 2 0 Minor capsid protein VI PSI PF01437.25 EKE38155.1 - 3.3 8.3 15.9 7.3 7.2 15.9 1.6 1 0 0 1 1 1 0 Plexin repeat PRP38 PF03371.15 EKE38156.1 - 1.4e-34 119.5 0.3 1.9e-34 119.0 0.3 1.1 1 0 0 1 1 1 1 PRP38 family PDR_assoc PF08370.11 EKE38156.1 - 0.031 14.0 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Plant PDR ABC transporter associated DUF5305 PF17231.2 EKE38157.1 - 0.032 13.6 0.6 0.048 13.1 0.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF4792 PF16040.5 EKE38157.1 - 0.055 13.4 0.1 0.21 11.5 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4792) Mob1_phocein PF03637.17 EKE38158.1 - 3.1e-58 196.5 0.4 3.7e-58 196.3 0.4 1.1 1 0 0 1 1 1 1 Mob1/phocein family Rbsn PF11464.8 EKE38159.1 - 0.013 15.2 0.4 0.013 15.2 0.4 5.6 4 0 0 4 4 4 0 Rabenosyn Rab binding domain INTS5_N PF14837.6 EKE38159.1 - 0.39 10.3 10.6 0.078 12.6 1.0 4.5 3 0 0 3 3 3 0 Integrator complex subunit 5 N-terminus Arg_decarbox_C PF17944.1 EKE38159.1 - 0.42 11.2 7.3 0.32 11.6 0.2 5.0 3 0 0 3 3 3 0 Arginine decarboxylase C-terminal helical extension DUF5362 PF17319.2 EKE38159.1 - 0.72 9.7 5.0 1.8 8.4 0.7 4.2 3 0 0 3 3 3 0 Family of unknown function (DUF5362) TRAP_beta PF05753.14 EKE38161.1 - 5.7e-10 38.9 1.1 1.1e-09 37.9 1.1 1.4 1 1 0 1 1 1 1 Translocon-associated protein beta (TRAPB) DUF11 PF01345.18 EKE38161.1 - 8.4e-07 29.2 1.0 1.4e-06 28.5 1.0 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF11 DUF1899 PF08953.11 EKE38162.1 - 4.4e-27 93.7 0.4 8.6e-27 92.8 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.32 EKE38162.1 - 1.9e-14 53.8 6.6 0.00039 21.2 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE38162.1 - 9e-08 32.3 0.9 0.0022 18.2 0.1 3.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EKE38162.1 - 0.0042 16.1 0.0 0.019 13.9 0.0 1.7 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4394 PF14339.6 EKE38162.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4394) WD40_4 PF16300.5 EKE38163.1 - 3.5e-17 62.0 0.2 5.4e-17 61.4 0.2 1.3 1 0 0 1 1 1 1 Type of WD40 repeat PKcGMP_CC PF16808.5 EKE38163.1 - 0.0039 17.0 1.1 0.0054 16.5 0.3 1.6 1 1 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Prefoldin_2 PF01920.20 EKE38163.1 - 0.0099 15.8 0.2 0.013 15.4 0.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit DUF641 PF04859.12 EKE38163.1 - 0.056 13.8 0.2 0.075 13.4 0.2 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Syntaphilin PF15290.6 EKE38163.1 - 0.061 13.0 1.4 0.091 12.4 1.4 1.1 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp Seryl_tRNA_N PF02403.22 EKE38163.1 - 0.13 12.5 1.2 0.2 11.9 1.2 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 EKE38163.1 - 0.2 10.3 0.4 0.62 8.6 0.3 1.7 2 0 0 2 2 2 0 Flagellar Assembly Protein A IFP_35_N PF07334.13 EKE38163.1 - 0.2 11.7 1.6 0.38 10.9 1.6 1.5 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Pro_isomerase PF00160.21 EKE38164.1 - 1.7e-42 145.4 0.1 2e-42 145.2 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MCPsignal PF00015.21 EKE38165.1 - 0.00034 20.5 14.2 0.0066 16.3 0.6 3.1 2 1 1 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain RmuC PF02646.16 EKE38165.1 - 0.0032 16.6 3.4 0.013 14.6 0.5 2.7 3 0 0 3 3 3 1 RmuC family DUF1664 PF07889.12 EKE38165.1 - 0.017 15.2 0.9 1.6 8.8 0.3 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 EKE38165.1 - 0.018 15.3 6.0 0.13 12.6 0.2 3.6 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) V-SNARE_C PF12352.8 EKE38165.1 - 0.027 14.7 0.3 46 4.4 0.1 3.3 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Laminin_I PF06008.14 EKE38165.1 - 0.21 11.2 1.7 0.4 10.4 1.7 1.5 1 1 0 1 1 1 0 Laminin Domain I TMP_2 PF06791.13 EKE38165.1 - 0.33 10.6 18.2 0.37 10.4 4.2 2.7 1 1 0 2 2 2 0 Prophage tail length tape measure protein ATG_C PF09333.11 EKE38165.1 - 0.36 11.2 11.8 0.24 11.8 1.8 2.9 2 2 0 2 2 2 0 Autophagy-related protein C terminal domain SKA1 PF07160.12 EKE38165.1 - 8.8 6.1 14.2 1.2 8.9 7.5 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 QLQ PF08880.11 EKE38166.1 - 0.085 12.6 0.1 0.14 12.0 0.1 1.3 1 0 0 1 1 1 0 QLQ Rhodanese PF00581.20 EKE38167.1 - 4.3e-14 52.9 0.0 9.3e-14 51.9 0.0 1.6 2 0 0 2 2 2 1 Rhodanese-like domain Ribonuclease_T2 PF00445.18 EKE38168.1 - 4.2e-32 111.8 8.3 6.3e-32 111.3 8.3 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family DUF2492 PF10678.9 EKE38168.1 - 0.029 14.7 0.0 0.11 12.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2492) RNB PF00773.19 EKE38169.1 - 7.2e-98 327.9 0.1 7.2e-98 327.9 0.1 1.9 3 0 0 3 3 3 1 RNB domain OB_Dis3 PF17849.1 EKE38169.1 - 5.5e-19 68.0 0.0 1.5e-18 66.6 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_S1 PF17215.3 EKE38169.1 - 3.6e-07 30.0 1.6 1.1e-06 28.5 1.6 1.8 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 EKE38169.1 - 1.2e-06 28.3 0.0 3.3e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain CSD2 PF17876.1 EKE38169.1 - 5.6e-06 26.4 0.1 0.00019 21.5 0.0 3.1 3 0 0 3 3 3 1 Cold shock domain 7TM_GPCR_Sra PF02117.16 EKE38171.1 - 0.068 12.0 0.8 0.24 10.2 0.3 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sra DUF3708 PF12501.8 EKE38171.1 - 0.93 9.3 4.2 0.3 10.9 0.1 2.1 2 1 1 3 3 3 0 Phosphate ATP-binding cassette transporter Ribosomal_L22 PF00237.19 EKE38172.1 - 3.4e-33 114.0 0.2 3.4e-33 114.0 0.2 1.4 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e SPRY PF00622.28 EKE38173.1 - 1.8e-15 57.1 2.2 1.8e-15 57.1 2.2 2.2 2 1 1 3 3 3 1 SPRY domain CCDC106 PF15794.5 EKE38173.1 - 4.5 6.9 9.5 0.2 11.3 0.7 2.3 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 106 DUF4094 PF13334.6 EKE38173.1 - 8.7 6.8 8.1 0.62 10.5 2.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) DENN PF02141.21 EKE38174.1 - 4.9e-27 95.1 0.6 4.9e-27 95.1 0.6 1.9 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 EKE38174.1 - 7.2e-07 29.9 0.0 1.6e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 uDENN domain MFS_1 PF07690.16 EKE38175.1 - 5.6e-35 120.9 24.0 1e-26 93.7 0.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily FAM176 PF14851.6 EKE38175.1 - 0.00086 19.0 0.1 0.39 10.4 0.1 2.4 2 0 0 2 2 2 2 FAM176 family G0-G1_switch_2 PF15103.6 EKE38175.1 - 0.01 16.2 0.0 0.062 13.7 0.1 2.1 2 0 0 2 2 2 0 G0/G1 switch protein 2 ICA69 PF04629.14 EKE38175.1 - 0.086 13.1 3.5 0.14 12.5 3.5 1.3 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain RhoGAP PF00620.27 EKE38176.1 - 3.1e-26 92.0 0.0 1.5e-25 89.8 0.0 2.3 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EKE38176.1 - 9.1e-18 64.2 19.7 1.2e-11 44.6 4.0 2.7 2 0 0 2 2 2 2 LIM domain Peptidase_S46 PF10459.9 EKE38176.1 - 2.8 6.5 23.9 5.3 5.6 23.9 1.4 1 0 0 1 1 1 0 Peptidase S46 Ras PF00071.22 EKE38178.1 - 5.2e-54 182.2 0.2 6e-54 182.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38178.1 - 4.5e-34 117.2 0.1 6.8e-34 116.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38178.1 - 3.9e-13 49.2 0.0 5.5e-13 48.7 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE38178.1 - 4.8e-12 45.8 0.1 8.7e-11 41.7 0.0 2.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE38178.1 - 4.6e-07 29.9 0.0 6.7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE38178.1 - 6.8e-07 29.3 0.0 0.014 15.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EKE38178.1 - 2.7e-05 23.6 0.0 3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EKE38178.1 - 4.1e-05 23.1 0.0 6.9e-05 22.4 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EKE38178.1 - 0.00021 21.6 0.0 0.001 19.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EKE38178.1 - 0.00038 20.2 0.1 0.001 18.9 0.1 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EKE38178.1 - 0.0016 18.0 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 EKE38178.1 - 0.005 17.0 0.0 0.0068 16.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EKE38178.1 - 0.0083 15.9 0.1 0.23 11.2 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 EKE38178.1 - 0.012 16.0 0.0 0.024 15.0 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EKE38178.1 - 0.014 15.4 0.0 0.037 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EKE38178.1 - 0.019 14.7 0.1 0.033 13.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 EKE38178.1 - 0.034 13.4 0.0 0.052 12.8 0.0 1.3 1 0 0 1 1 1 0 Septin TniB PF05621.11 EKE38178.1 - 0.064 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.29 EKE38178.1 - 0.066 13.6 0.0 0.11 13.0 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EKE38178.1 - 0.068 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain HMGL-like PF00682.19 EKE38179.1 - 0.0061 16.2 2.2 0.0061 16.2 2.2 1.9 2 0 0 2 2 2 1 HMGL-like DUF3437 PF11919.8 EKE38179.1 - 0.09 12.7 0.1 0.3 11.1 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) DUF883 PF05957.13 EKE38179.1 - 1.7 9.3 11.1 2.9 8.5 1.1 3.8 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF883) Rap_GAP PF02145.15 EKE38180.1 - 2.1e-61 206.8 1.0 3.1e-61 206.2 0.4 1.6 2 0 0 2 2 2 1 Rap/ran-GAP RabGAP-TBC PF00566.18 EKE38181.1 - 2.9e-29 102.2 8.1 1.6e-26 93.3 5.0 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Peptidase_S74 PF13884.6 EKE38182.1 - 1.6e-12 47.5 0.2 5e-12 45.9 0.2 1.9 1 0 0 1 1 1 1 Chaperone of endosialidase Thioredoxin PF00085.20 EKE38183.1 - 1.8e-10 40.7 0.5 2.1e-10 40.5 0.5 1.1 1 0 0 1 1 1 1 Thioredoxin DUF2883 PF11097.8 EKE38183.1 - 0.074 13.2 1.4 0.63 10.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2883) Cullin_binding PF03556.15 EKE38184.1 - 0.0001 22.7 0.0 0.00022 21.7 0.0 1.5 1 0 0 1 1 1 1 Cullin binding Njmu-R1 PF15053.6 EKE38184.1 - 0.014 14.5 0.5 0.17 11.0 0.2 2.0 2 0 0 2 2 2 0 Mjmu-R1-like protein family DUF2740 PF10872.8 EKE38184.1 - 0.1 12.5 0.0 0.3 11.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2740) RasGEF PF00617.19 EKE38185.1 - 3.1e-58 196.9 0.1 8.6e-58 195.4 0.1 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE38185.1 - 2.5e-15 56.6 2.2 4.7e-15 55.7 0.4 2.5 1 1 1 2 2 2 1 RasGEF N-terminal motif Actin PF00022.19 EKE38185.1 - 0.03 12.9 1.2 0.051 12.2 1.2 1.4 1 0 0 1 1 1 0 Actin Ribosomal_L26 PF16906.5 EKE38186.1 - 1.2e-30 105.8 2.5 2.7e-30 104.7 2.5 1.6 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal Pkinase PF00069.25 EKE38189.1 - 1e-56 192.2 0.0 1.7e-56 191.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38189.1 - 8.8e-42 143.2 0.0 1.4e-41 142.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE38189.1 - 2e-06 27.3 0.0 3.6e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PBD PF00786.28 EKE38189.1 - 1e-05 25.8 0.2 3.8e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 EKE38189.1 - 3.8e-05 22.7 0.0 6.5e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKE38189.1 - 0.23 11.4 0.1 0.37 10.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-MIZ PF02891.20 EKE38190.1 - 3.4e-14 52.3 3.2 3.4e-14 52.3 3.2 1.9 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EKE38190.1 - 5.8e-07 29.2 1.0 2.4e-06 27.3 1.0 2.1 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-4CXXC_R1 PF10497.9 EKE38190.1 - 0.18 12.0 2.3 0.4 10.9 2.3 1.5 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 SidC_N PF18219.1 EKE38191.1 - 0.011 14.8 0.6 0.02 13.9 0.4 1.4 1 1 1 2 2 2 0 SidC N-terminal domain Peptidase_C3 PF00548.20 EKE38191.1 - 0.053 13.4 0.1 0.091 12.7 0.1 1.3 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) TRAP_alpha PF03896.16 EKE38193.1 - 0.096 11.9 3.8 0.11 11.7 3.8 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Astro_capsid_p PF12226.8 EKE38193.1 - 1 8.5 8.1 1.3 8.1 8.1 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DENN PF02141.21 EKE38194.1 - 2.7e-14 53.6 0.7 2.7e-14 53.6 0.7 2.3 3 0 0 3 3 3 1 DENN (AEX-3) domain dDENN PF03455.19 EKE38194.1 - 3.4e-07 30.1 3.9 3.4e-07 30.1 3.9 2.5 3 0 0 3 3 3 1 dDENN domain uDENN PF03456.18 EKE38194.1 - 5.8e-05 23.7 1.1 0.0002 22.0 0.9 2.1 2 0 0 2 2 2 1 uDENN domain Myosin_TH1 PF06017.13 EKE38195.1 - 0.026 14.2 1.7 0.29 10.8 0.1 2.6 3 0 0 3 3 3 0 Unconventional myosin tail, actin- and lipid-binding CNH PF00780.22 EKE38195.1 - 0.14 11.7 3.0 0.12 12.0 0.6 2.1 1 1 1 2 2 2 0 CNH domain PUNUT PF16913.5 EKE38196.1 - 1.1e-05 24.8 3.7 1.1e-05 24.8 3.7 3.7 3 1 1 4 4 4 1 Purine nucleobase transmembrane transport EamA PF00892.20 EKE38196.1 - 1.4e-05 25.3 1.1 1.4e-05 25.3 1.1 4.3 3 2 0 3 3 3 1 EamA-like transporter family DUF1418 PF07214.12 EKE38196.1 - 0.00084 19.1 0.3 1.3 8.9 0.1 3.6 2 1 0 2 2 2 2 Protein of unknown function (DUF1418) DUF2570 PF10828.8 EKE38196.1 - 0.035 13.9 0.3 0.1 12.5 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) DUF2157 PF09925.9 EKE38196.1 - 0.048 13.4 0.0 0.048 13.4 0.0 3.3 3 1 0 3 3 3 0 Predicted membrane protein (DUF2157) PrmA PF06325.13 EKE38197.1 - 6.4e-11 42.2 0.0 8.6e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EKE38197.1 - 2e-09 38.1 0.1 7.6e-09 36.2 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EKE38197.1 - 5e-09 36.1 0.0 1.1e-08 35.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKE38197.1 - 3.5e-08 33.4 0.0 7.7e-07 29.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKE38197.1 - 8.6e-08 32.7 0.0 4.3e-07 30.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 EKE38197.1 - 3.7e-07 30.2 0.1 7.4e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EKE38197.1 - 8.2e-06 25.5 0.0 1.4e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EKE38197.1 - 1.1e-05 24.9 0.1 1.5e-05 24.4 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PRMT5 PF05185.16 EKE38197.1 - 1.8e-05 24.6 0.1 4.5e-05 23.4 0.1 1.7 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase Met_10 PF02475.16 EKE38197.1 - 2.2e-05 24.3 0.1 3.3e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_9 PF08003.11 EKE38197.1 - 0.00033 19.7 0.0 0.00047 19.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) TehB PF03848.14 EKE38197.1 - 0.00054 19.4 0.2 0.002 17.6 0.0 1.9 2 0 0 2 2 2 1 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 EKE38197.1 - 0.00077 20.2 0.0 0.0015 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EKE38197.1 - 0.0037 18.3 0.0 0.0063 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EKE38197.1 - 0.0073 16.4 0.0 0.017 15.2 0.0 1.9 1 1 0 1 1 1 1 FtsJ-like methyltransferase NNMT_PNMT_TEMT PF01234.17 EKE38197.1 - 0.0075 15.5 0.0 0.027 13.7 0.0 1.8 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family PRMT5_C PF17286.2 EKE38197.1 - 0.01 15.7 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 0 PRMT5 oligomerisation domain Cons_hypoth95 PF03602.15 EKE38197.1 - 0.012 15.2 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_32 PF13679.6 EKE38197.1 - 0.026 14.5 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EKE38197.1 - 0.03 14.1 0.2 0.046 13.5 0.2 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EKE38197.1 - 0.12 11.8 0.1 0.18 11.2 0.1 1.2 1 0 0 1 1 1 0 Putative methyltransferase NDUF_B12 PF08122.12 EKE38198.1 - 0.88 9.7 6.0 17 5.5 2.2 2.6 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family DUF4149 PF13664.6 EKE38198.1 - 5.2 7.5 8.9 1 9.7 2.2 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4149) Ephrin_rec_like PF07699.13 EKE38199.1 - 1.1e-16 60.3 78.7 7.1e-07 28.9 7.4 8.8 2 2 5 9 9 9 8 Putative ephrin-receptor like Chordopox_G2 PF05796.12 EKE38199.1 - 0.0061 16.0 1.1 0.015 14.7 1.1 1.6 1 0 0 1 1 1 1 Chordopoxvirus protein G2 Bactofilin PF04519.13 EKE38199.1 - 2.1 8.7 15.4 2.3 8.6 6.2 4.2 3 0 0 3 3 3 0 Polymer-forming cytoskeletal Pkinase PF00069.25 EKE38200.1 - 3.5e-69 233.1 0.0 4e-69 232.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38200.1 - 1.2e-33 116.5 0.0 1.5e-33 116.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EKE38200.1 - 0.0001 21.4 0.2 0.00023 20.2 0.2 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EKE38200.1 - 0.0034 16.7 0.0 0.005 16.2 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKE38200.1 - 0.22 10.9 0.0 0.63 9.4 0.0 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EKE38201.1 - 3.8e-48 164.1 0.3 7e-48 163.3 0.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38201.1 - 2.9e-45 154.6 0.0 5.2e-45 153.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE38201.1 - 6.3e-09 35.1 0.1 1.1e-08 34.3 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase VSP PF03302.13 EKE38201.1 - 4e-05 22.7 32.2 4e-05 22.7 32.2 4.7 1 1 3 4 4 4 2 Giardia variant-specific surface protein Bactofilin PF04519.13 EKE38201.1 - 0.0065 16.7 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 Polymer-forming cytoskeletal Methyltransf_16 PF10294.9 EKE38203.1 - 1.5e-14 54.1 0.1 1.9e-14 53.8 0.1 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EKE38203.1 - 9.1e-08 32.1 0.0 2e-07 31.0 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE38203.1 - 3.5e-07 30.8 0.0 5.2e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EKE38203.1 - 1.8e-06 27.8 0.0 2.7e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EKE38203.1 - 8.5e-06 25.3 0.1 1.2e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.14 EKE38203.1 - 8.9e-06 25.4 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EKE38203.1 - 1.7e-05 25.5 0.0 2.6e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKE38203.1 - 8.3e-05 23.2 0.0 0.00012 22.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EKE38203.1 - 0.0031 17.3 0.1 0.0085 15.9 0.0 1.7 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 EKE38203.1 - 0.05 13.0 0.0 0.068 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) SeqA_N PF17206.3 EKE38203.1 - 0.21 10.9 0.1 0.21 10.9 0.1 2.4 3 0 0 3 3 3 0 SeqA protein N-terminal domain Pkinase PF00069.25 EKE38204.1 - 5.4e-48 163.6 0.7 5.4e-48 163.6 0.7 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38204.1 - 7.3e-31 107.4 0.7 1.7e-30 106.2 0.1 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Med21 PF11221.8 EKE38205.1 - 5.5e-10 39.7 0.4 7.9e-10 39.2 0.4 1.4 1 1 0 1 1 1 1 Subunit 21 of Mediator complex DUF3638 PF12340.8 EKE38205.1 - 0.066 12.5 0.1 0.091 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) BSMAP PF12280.8 EKE38206.1 - 0.29 11.3 4.9 1.2 9.3 3.5 2.2 1 1 1 2 2 2 0 Brain specific membrane anchored protein CK_II_beta PF01214.18 EKE38207.1 - 2.8e-67 226.1 0.0 3.2e-67 225.9 0.0 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit UPF0228 PF05727.11 EKE38207.1 - 0.07 13.0 0.0 0.57 10.0 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0228) Choline_kinase PF01633.20 EKE38208.1 - 2.3e-43 148.3 0.4 7e-43 146.7 0.1 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EKE38208.1 - 2.4e-05 24.4 0.0 3.5e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EKE38208.1 - 0.12 11.6 0.3 0.29 10.4 0.3 1.6 1 0 0 1 1 1 0 Ecdysteroid kinase Arginase PF00491.21 EKE38209.1 - 3.4e-57 194.1 0.0 3.9e-57 193.9 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EKE38209.1 - 0.14 12.4 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 UPF0489 domain Aminotran_4 PF01063.19 EKE38211.1 - 7.5e-29 101.2 0.2 1.8e-28 99.9 0.2 1.6 1 1 0 1 1 1 1 Amino-transferase class IV Aminotran_1_2 PF00155.21 EKE38213.1 - 1.8e-22 80.0 0.0 2.3e-22 79.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EKE38213.1 - 0.0083 14.7 0.1 0.031 12.8 0.0 1.8 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EKE38214.1 - 1.8e-16 60.2 0.0 2.2e-16 60.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4110 PF13422.6 EKE38216.1 - 0.028 14.5 0.9 0.15 12.1 0.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4110) Lipoprotein_10 PF03202.13 EKE38216.1 - 0.13 12.7 4.1 0.15 12.5 0.2 2.5 3 0 0 3 3 3 0 Putative mycoplasma lipoprotein, C-terminal region zf-LITAF-like PF10601.9 EKE38220.1 - 2.9e-18 65.9 17.3 4e-18 65.4 17.3 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain 5TM-5TMR_LYT PF07694.12 EKE38220.1 - 0.073 12.6 1.1 0.1 12.1 1.1 1.1 1 0 0 1 1 1 0 5TMR of 5TMR-LYT Abhydrolase_1 PF00561.20 EKE38222.1 - 2.3e-06 27.5 0.0 2.9e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EKE38222.1 - 3.8e-05 23.1 0.0 5.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EKE38222.1 - 0.00026 21.7 0.0 0.00053 20.7 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Cutinase PF01083.22 EKE38222.1 - 0.0026 17.7 0.0 0.0037 17.3 0.0 1.2 1 0 0 1 1 1 1 Cutinase Palm_thioest PF02089.15 EKE38222.1 - 0.016 15.0 0.0 0.02 14.8 0.0 1.1 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Thioesterase PF00975.20 EKE38222.1 - 0.019 15.1 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.13 EKE38222.1 - 0.045 13.5 0.0 0.076 12.7 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein VirJ PF06057.11 EKE38222.1 - 0.16 11.9 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Abhydrolase_3 PF07859.13 EKE38222.1 - 0.19 11.6 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold WD40 PF00400.32 EKE38223.1 - 0.081 13.8 0.1 3 8.9 0.0 3.1 3 0 0 3 3 3 0 WD domain, G-beta repeat PAP_central PF04928.17 EKE38225.1 - 1e-46 158.9 1.3 1.2e-46 158.8 0.1 1.7 2 0 0 2 2 2 1 Poly(A) polymerase central domain NTP_transf_2 PF01909.23 EKE38225.1 - 8e-08 32.5 0.0 3.2e-07 30.5 0.0 2.0 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EKE38225.1 - 0.0004 20.4 0.1 0.0016 18.5 0.1 2.1 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Nrap_D2 PF17403.2 EKE38225.1 - 0.0056 16.5 0.2 0.013 15.3 0.0 1.7 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain PAP_RNA-bind PF04926.15 EKE38225.1 - 0.026 14.2 0.2 9.1 5.9 0.0 3.3 1 1 2 3 3 3 0 Poly(A) polymerase predicted RNA binding domain UPF0160 PF03690.13 EKE38226.1 - 1.2e-90 304.4 0.0 1.3e-90 304.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Ist1 PF03398.14 EKE38226.1 - 0.044 13.7 0.1 0.41 10.6 0.0 2.1 2 0 0 2 2 2 0 Regulator of Vps4 activity in the MVB pathway SNARE PF05739.19 EKE38227.1 - 1.9e-06 27.8 1.6 1.9e-06 27.8 1.6 2.2 1 1 1 2 2 2 1 SNARE domain Use1 PF09753.9 EKE38227.1 - 4.5e-05 23.3 1.1 5.4e-05 23.0 1.1 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 CD225 PF04505.12 EKE38227.1 - 0.00012 22.1 0.9 0.00012 22.1 0.9 2.2 1 1 1 2 2 2 1 Interferon-induced transmembrane protein Prominin PF05478.11 EKE38227.1 - 0.0015 16.6 0.7 0.0017 16.4 0.7 1.0 1 0 0 1 1 1 1 Prominin DUF2407_C PF13373.6 EKE38227.1 - 0.0026 18.0 0.1 0.003 17.7 0.1 1.1 1 0 0 1 1 1 1 DUF2407 C-terminal domain RIFIN PF02009.16 EKE38227.1 - 0.0035 17.3 5.7 0.0038 17.2 5.7 1.0 1 0 0 1 1 1 1 Rifin GP41 PF00517.17 EKE38227.1 - 0.0036 17.2 1.0 0.0043 17.0 1.0 1.1 1 0 0 1 1 1 1 Retroviral envelope protein Collectrin PF16959.5 EKE38227.1 - 0.0068 16.2 0.4 0.0076 16.0 0.4 1.2 1 0 0 1 1 1 1 Renal amino acid transporter DUF2207 PF09972.9 EKE38227.1 - 0.0094 14.8 0.1 0.0096 14.7 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF3827 PF12877.7 EKE38227.1 - 0.01 14.2 8.0 0.011 14.1 8.0 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF3827) Amnionless PF14828.6 EKE38227.1 - 0.021 13.7 0.5 0.023 13.5 0.5 1.0 1 0 0 1 1 1 0 Amnionless Orf78 PF06024.12 EKE38227.1 - 0.031 14.6 3.7 0.047 14.0 3.7 1.5 1 1 0 1 1 1 0 Orf78 (ac78) Mid2 PF04478.12 EKE38227.1 - 0.038 13.8 3.4 0.039 13.8 2.0 1.6 1 1 1 2 2 2 0 Mid2 like cell wall stress sensor Shisa PF13908.6 EKE38227.1 - 0.049 13.9 0.4 0.065 13.5 0.4 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator CwsA PF10814.8 EKE38227.1 - 0.051 13.8 1.5 0.068 13.3 1.5 1.4 1 1 0 1 1 1 0 Cell wall synthesis protein CwsA LRRC37AB_C PF14914.6 EKE38227.1 - 0.057 13.3 1.0 0.068 13.1 1.0 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Sec62 PF03839.16 EKE38227.1 - 0.077 12.5 0.3 0.088 12.3 0.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 ATP-synt_S1 PF05827.12 EKE38227.1 - 0.1 12.4 1.9 0.16 11.8 1.9 1.4 1 1 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) Synaptobrevin PF00957.21 EKE38227.1 - 0.1 12.4 5.8 0.17 11.7 5.8 1.5 1 1 0 1 1 1 0 Synaptobrevin DUF5383 PF17355.2 EKE38227.1 - 0.2 12.0 1.9 0.28 11.6 1.9 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5383) Renin_r PF07850.14 EKE38227.1 - 0.38 11.4 2.4 0.53 10.9 2.4 1.3 1 1 0 1 1 1 0 Renin receptor-like protein NAM-associated PF14303.6 EKE38227.1 - 0.41 11.4 6.7 0.43 11.3 6.7 1.0 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Protocadherin PF08374.11 EKE38227.1 - 0.54 10.2 5.7 0.57 10.1 4.8 1.4 1 1 0 1 1 1 0 Protocadherin XhlA PF10779.9 EKE38227.1 - 1.5 9.0 17.1 0.29 11.3 12.4 2.1 2 1 0 2 2 1 0 Haemolysin XhlA TRIQK PF15168.6 EKE38227.1 - 3 7.8 5.7 7.6 6.5 5.7 1.7 1 1 0 1 1 1 0 Triple QxxK/R motif-containing protein family DUF724 PF05266.14 EKE38227.1 - 5.1 6.9 6.4 6.2 6.6 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) NPR1_interact PF15699.5 EKE38229.1 - 0.0082 16.8 0.6 0.02 15.5 0.6 1.6 1 0 0 1 1 1 1 NPR1 interacting RFX5_DNA_bdg PF14621.6 EKE38229.1 - 0.023 14.5 3.5 0.034 13.9 3.5 1.2 1 0 0 1 1 1 0 RFX5 DNA-binding domain RESP18 PF14948.6 EKE38229.1 - 0.27 11.5 1.5 6 7.2 0.2 2.4 2 0 0 2 2 2 0 RESP18 domain DUF919 PF06034.11 EKE38230.1 - 0.015 15.1 7.7 0.025 14.4 7.7 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) PACT_coil_coil PF10495.9 EKE38230.1 - 0.08 13.5 1.8 0.12 13.0 1.8 1.3 1 0 0 1 1 1 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein NPV_P10 PF05531.12 EKE38230.1 - 0.16 12.5 4.8 0.2 12.1 4.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein FPP PF05911.11 EKE38230.1 - 0.37 8.9 9.5 0.4 8.8 9.5 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Med4 PF10018.9 EKE38230.1 - 0.46 10.1 6.8 0.53 9.9 6.8 1.1 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 FapA PF03961.13 EKE38230.1 - 0.82 8.2 5.1 0.84 8.2 5.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A LRR_5 PF13306.6 EKE38231.1 - 7.5e-24 84.1 0.8 7.5e-24 84.1 0.8 2.2 2 0 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE38231.1 - 1.9e-05 24.3 0.2 0.00089 19.0 0.2 2.6 2 1 0 2 2 2 1 Leucine rich repeat Sec1 PF00995.23 EKE38232.1 - 3.7e-13 49.6 18.7 1.9e-11 43.9 16.4 2.3 1 1 1 2 2 2 2 Sec1 family EssA PF10661.9 EKE38233.1 - 0.011 15.6 1.2 0.013 15.4 1.2 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA Synaphin PF05835.12 EKE38233.1 - 0.044 14.1 1.3 0.052 13.8 1.3 1.1 1 0 0 1 1 1 0 Synaphin protein Metallophos PF00149.28 EKE38238.1 - 1.7e-11 45.0 0.6 3.1e-11 44.2 0.6 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase VWA_2 PF13519.6 EKE38239.1 - 0.00026 21.6 0.2 0.0025 18.4 0.0 2.6 2 1 0 3 3 3 1 von Willebrand factor type A domain VWA PF00092.28 EKE38239.1 - 0.00026 21.3 2.6 0.00038 20.7 0.5 2.4 2 1 0 2 2 2 1 von Willebrand factor type A domain Ku_N PF03731.15 EKE38239.1 - 0.00038 20.3 1.0 0.11 12.2 0.1 2.7 2 1 0 2 2 2 2 Ku70/Ku80 N-terminal alpha/beta domain Xpo1 PF08389.12 EKE38239.1 - 0.0084 16.2 0.3 0.055 13.5 0.1 2.4 2 1 0 2 2 2 1 Exportin 1-like protein Brix PF04427.18 EKE38241.1 - 2.7e-33 115.7 0.3 2.7e-33 115.7 0.3 1.4 2 0 0 2 2 2 1 Brix domain Presenilin PF01080.17 EKE38241.1 - 1.9 7.1 5.0 3.4 6.3 5.0 1.4 1 0 0 1 1 1 0 Presenilin MDM10 PF12519.8 EKE38241.1 - 3.8 6.3 8.3 0.69 8.7 4.8 1.5 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 DUF4407 PF14362.6 EKE38241.1 - 8.5 5.6 8.9 0.26 10.6 2.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HVSL PF09749.9 EKE38242.1 - 3.2e-26 92.3 1.5 5.3e-26 91.6 1.5 1.4 1 1 0 1 1 1 1 Uncharacterised conserved protein 2_5_RNA_ligase2 PF13563.6 EKE38242.1 - 0.0022 17.9 0.2 0.0047 16.9 0.0 1.6 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily Syntaxin-6_N PF09177.11 EKE38243.1 - 0.027 15.0 3.9 0.14 12.7 3.8 2.2 1 1 0 1 1 1 0 Syntaxin 6, N-terminal TLD PF07534.16 EKE38243.1 - 0.44 10.8 13.8 2.3 8.5 0.6 2.6 2 0 0 2 2 2 0 TLD TSC22 PF01166.18 EKE38243.1 - 9 6.7 10.4 5.8 7.3 3.7 3.0 1 1 1 2 2 2 0 TSC-22/dip/bun family Pkinase_Tyr PF07714.17 EKE38244.1 - 7e-49 166.4 0.0 1.1e-48 165.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38244.1 - 1.1e-35 123.3 0.1 2.3e-35 122.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain TMEM131_like PF12371.8 EKE38244.1 - 0.017 15.4 0.3 0.037 14.3 0.3 1.6 1 0 0 1 1 1 0 Transmembrane protein 131-like Syndecan PF01034.20 EKE38244.1 - 0.15 12.0 5.7 0.31 11.0 5.7 1.4 1 0 0 1 1 1 0 Syndecan domain FGGY_N PF00370.21 EKE38245.1 - 4.4e-49 167.3 0.0 6.3e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EKE38245.1 - 1.4e-08 34.7 0.0 1.9e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain CN_hydrolase PF00795.22 EKE38246.1 - 1.7e-23 83.3 0.1 1.9e-23 83.1 0.1 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Rhomboid PF01694.22 EKE38247.1 - 1.5e-17 64.0 16.5 7.8e-17 61.7 16.5 2.0 1 1 0 1 1 1 1 Rhomboid family SAC3 PF12209.8 EKE38247.1 - 0.018 15.2 0.1 0.082 13.1 0.0 2.0 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain Pkinase PF00069.25 EKE38249.1 - 1.7e-89 299.7 3.8 7.5e-53 179.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38249.1 - 1.5e-56 191.6 0.2 6.3e-32 110.9 0.0 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EKE38249.1 - 0.00053 19.4 0.0 0.25 10.6 0.0 2.5 2 1 0 2 2 2 2 Kinase-like APH PF01636.23 EKE38249.1 - 0.025 14.5 0.0 1.5 8.7 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Rrp15p PF07890.12 EKE38250.1 - 5.9e-15 55.8 8.1 5.9e-15 55.8 8.1 2.8 1 1 1 2 2 2 1 Rrp15p DUF913 PF06025.12 EKE38250.1 - 0.94 8.4 11.3 1.8 7.4 11.3 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Peptidase_C1 PF00112.23 EKE38251.1 - 1.9e-76 257.0 2.3 2.5e-76 256.6 2.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE38251.1 - 8.7e-07 29.3 4.6 1.6e-06 28.5 4.6 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EKE38251.1 - 0.00022 20.1 0.3 0.009 14.8 0.3 2.2 2 0 0 2 2 2 2 Peptidase C1-like family PhoLip_ATPase_C PF16212.5 EKE38253.1 - 5.4e-42 144.3 30.1 5.4e-42 144.3 30.1 2.9 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EKE38253.1 - 3.3e-16 58.7 9.3 1.1e-15 57.0 9.3 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EKE38253.1 - 5.2e-14 52.2 0.0 5.2e-14 52.2 0.0 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EKE38253.1 - 5.4e-14 52.0 0.3 7.9e-13 48.3 0.1 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EKE38253.1 - 4.8e-12 46.6 1.1 6.9e-06 26.5 0.7 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EKE38253.1 - 0.0048 16.7 1.9 0.027 14.2 1.2 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TetR_C_12 PF16914.5 EKE38253.1 - 0.1 12.7 0.4 1.3 9.2 0.0 2.7 2 1 1 3 3 3 0 Bacterial transcriptional repressor C-terminal SpoU_methylase PF00588.19 EKE38253.1 - 0.17 12.0 0.7 13 5.9 0.0 3.6 3 1 1 4 4 4 0 SpoU rRNA Methylase family ACPS PF01648.20 EKE38254.1 - 2.6e-10 40.4 0.0 4.3e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily DUF3810 PF12725.7 EKE38255.1 - 0.0071 15.7 2.3 0.0071 15.7 2.3 1.8 1 1 0 2 2 2 1 Protein of unknown function (DUF3810) Tetraspanin PF00335.20 EKE38255.1 - 0.43 10.2 24.9 26 4.4 25.3 2.7 1 1 0 1 1 1 0 Tetraspanin family Saf_2TM PF18303.1 EKE38255.1 - 3.5 7.2 9.7 3.9 7.0 0.1 2.6 2 1 0 2 2 2 0 SAVED-fused 2TM effector domain DUF4600 PF15372.6 EKE38256.1 - 0.0014 19.1 0.5 0.0022 18.4 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4600) DUF4006 PF13179.6 EKE38256.1 - 0.018 15.0 0.1 0.035 14.0 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF4006) MLANA PF14991.6 EKE38256.1 - 0.093 13.0 1.2 0.11 12.8 0.5 1.6 1 1 1 2 2 2 0 Protein melan-A Myb_DNA-binding PF00249.31 EKE38258.1 - 4.3e-30 103.7 6.9 2.2e-15 56.6 0.8 2.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE38258.1 - 1.2e-24 86.3 6.8 3.5e-14 52.8 2.1 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EKE38258.1 - 4.7e-11 42.4 2.2 1.3e-05 25.0 0.0 2.3 2 1 0 2 2 2 2 Myb DNA-binding like SLIDE PF09111.10 EKE38258.1 - 6.3e-08 32.6 1.3 0.0024 17.9 0.2 2.3 1 1 1 2 2 2 2 SLIDE SANT_DAMP1_like PF16282.5 EKE38258.1 - 2.4e-05 24.4 2.5 0.0068 16.6 0.2 2.4 1 1 1 2 2 2 2 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_2 PF08914.11 EKE38258.1 - 0.023 14.9 4.1 9.1 6.5 0.4 3.5 1 1 1 2 2 2 0 Rap1 Myb domain F1F0-ATPsyn_F PF10791.9 EKE38258.1 - 0.096 13.2 0.1 0.35 11.4 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi PRKCSH-like PF12999.7 EKE38259.1 - 3e-05 23.9 7.8 3e-05 23.9 7.8 2.5 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EKE38259.1 - 0.021 14.5 1.0 0.021 14.5 1.0 2.0 2 0 0 2 2 2 0 Glucosidase II beta subunit-like protein DUF5529 PF17669.1 EKE38259.1 - 0.17 11.9 0.4 2.2 8.3 0.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5529) DUF1512 PF07431.12 EKE38259.1 - 0.78 8.7 5.9 0.37 9.7 1.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1512) Plasmod_Pvs28 PF06247.11 EKE38259.1 - 7 7.1 8.8 23 5.4 2.3 2.9 2 0 0 2 2 2 0 Pvs28 EGF domain Cofilin_ADF PF00241.20 EKE38261.1 - 2.3e-21 75.8 0.0 2.9e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Gryzun-like PF12742.7 EKE38262.1 - 1.1e-07 31.7 0.0 3.2e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking DUF5588 PF17826.1 EKE38262.1 - 0.0018 17.3 0.6 0.0028 16.6 0.6 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5588) TRAPPC10 PF12584.8 EKE38262.1 - 0.015 15.0 0.1 0.047 13.4 0.0 1.9 2 0 0 2 2 2 0 Trafficking protein particle complex subunit 10, TRAPPC10 DUF4727 PF15856.5 EKE38262.1 - 0.058 13.0 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4727) DUF3211 PF11485.8 EKE38262.1 - 0.06 13.6 6.1 2.4 8.4 0.0 4.3 3 1 0 4 4 4 0 Protein of unknown function (DUF3211) Vps39_1 PF10366.9 EKE38262.1 - 0.1 12.9 2.5 0.22 11.8 0.1 2.7 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 RL10P_insert PF17777.1 EKE38263.1 - 0.044 13.8 0.1 0.19 11.7 0.1 2.1 1 1 0 1 1 1 0 Insertion domain in 60S ribosomal protein L10P WD40 PF00400.32 EKE38264.1 - 6.8e-24 83.7 22.5 7.1e-08 33.0 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE38264.1 - 3.2e-11 43.4 3.9 0.0064 16.8 0.0 6.3 3 3 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EKE38264.1 - 9.6e-05 21.2 7.0 0.14 10.8 0.1 4.5 2 1 3 5 5 5 3 Nucleoporin Nup120/160 ERM PF00769.19 EKE38264.1 - 0.0032 17.3 6.5 0.005 16.7 6.5 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family ATG16 PF08614.11 EKE38264.1 - 0.012 15.9 14.2 0.012 15.9 14.2 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SUKH_6 PF14568.6 EKE38264.1 - 0.032 14.7 0.0 1.6 9.2 0.0 2.9 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall DUF5122 PF17164.4 EKE38264.1 - 0.047 14.0 0.1 3.1 8.2 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller Ge1_WD40 PF16529.5 EKE38264.1 - 0.077 11.9 0.0 0.077 11.9 0.0 3.5 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein KRAP_IP3R_bind PF14722.6 EKE38264.1 - 0.11 12.2 2.8 0.086 12.6 0.9 1.7 1 1 1 2 2 2 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain HAUS-augmin3 PF14932.6 EKE38264.1 - 0.21 11.2 12.5 0.41 10.2 11.6 1.8 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 YqgF PF14639.6 EKE38264.1 - 0.22 11.3 8.8 4.1 7.2 7.5 2.4 2 0 0 2 2 2 0 Holliday-junction resolvase-like of SPT6 V_ATPase_I PF01496.19 EKE38264.1 - 0.43 8.4 7.6 0.6 8.0 7.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6_N PF17675.1 EKE38264.1 - 0.77 10.3 16.9 0.14 12.7 1.8 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region Fez1 PF06818.15 EKE38264.1 - 0.81 10.1 14.2 0.36 11.2 11.2 1.7 1 1 0 1 1 1 0 Fez1 Leu_zip PF15294.6 EKE38264.1 - 0.9 9.0 18.0 3.9 6.9 17.3 1.9 1 1 1 2 2 2 0 Leucine zipper zf-C4H2 PF10146.9 EKE38264.1 - 2.6 8.3 18.0 5.8 7.2 18.0 1.5 1 1 0 1 1 1 0 Zinc finger-containing protein LMBR1 PF04791.16 EKE38264.1 - 3.3 6.5 7.9 4.7 6.0 7.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Synaptobrevin PF00957.21 EKE38265.1 - 4.4e-10 39.2 0.4 1.5e-09 37.5 0.4 1.9 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EKE38265.1 - 3.4e-06 27.0 0.1 5.7e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF4849 PF16141.5 EKE38265.1 - 0.055 12.7 0.3 0.055 12.7 0.3 1.7 2 0 0 2 2 2 0 Putative glycoside hydrolase Family 18, chitinase_18 Seryl_tRNA_N PF02403.22 EKE38265.1 - 0.14 12.4 6.5 0.32 11.2 0.4 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain BLOC1_2 PF10046.9 EKE38265.1 - 0.42 10.9 4.1 0.31 11.4 0.6 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_DNA_bd PF12329.8 EKE38265.1 - 0.86 9.6 7.9 1.7 8.7 1.0 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Tmemb_9 PF05434.11 EKE38265.1 - 2.1 8.2 5.7 0.34 10.8 1.2 2.0 2 1 0 2 2 2 0 TMEM9 CSRNP_N PF16019.5 EKE38266.1 - 1.4e-06 28.4 19.0 0.00074 19.5 0.0 2.1 1 1 1 2 2 2 2 Cysteine/serine-rich nuclear protein N-terminus Ras PF00071.22 EKE38267.1 - 1.9e-44 151.1 0.5 2.2e-44 150.9 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38267.1 - 7.6e-29 100.4 0.2 1.1e-28 99.9 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38267.1 - 7.4e-14 51.6 0.0 9.9e-14 51.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE38267.1 - 4.4e-06 26.8 0.1 6e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE38267.1 - 0.00031 20.3 0.1 0.0023 17.5 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKE38267.1 - 0.0021 17.5 0.1 0.0033 16.9 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EKE38267.1 - 0.0096 15.3 0.1 0.012 14.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.11 EKE38267.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 EKE38267.1 - 0.019 14.7 0.1 0.035 13.9 0.1 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ADH_zinc_N PF00107.26 EKE38267.1 - 0.059 13.3 0.0 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 Zinc-binding dehydrogenase ATPase_2 PF01637.18 EKE38267.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF5441 PF17513.2 EKE38267.1 - 0.21 11.3 0.0 0.31 10.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5441) DIL PF01843.19 EKE38268.1 - 4.3e-09 36.6 2.4 1.7e-08 34.6 0.1 3.1 3 0 0 3 3 3 1 DIL domain Ribosomal_L29 PF00831.23 EKE38268.1 - 0.59 10.2 7.2 3.9 7.5 0.1 4.2 5 0 0 5 5 5 0 Ribosomal L29 protein Pkinase PF00069.25 EKE38269.1 - 4.2e-53 180.4 0.1 1e-52 179.2 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38269.1 - 8.6e-23 80.9 0.2 4.3e-22 78.7 0.2 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 EKE38269.1 - 2.3e-07 30.6 0.2 3.3e-06 26.8 0.0 2.7 3 0 0 3 3 3 1 RIO1 family FTA2 PF13095.6 EKE38269.1 - 0.0013 18.4 0.5 0.059 13.0 0.0 2.5 1 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EKE38269.1 - 0.0013 18.7 0.0 0.002 18.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family PIP49_C PF12260.8 EKE38269.1 - 0.0031 17.2 0.1 0.0074 15.9 0.1 1.6 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Choline_kinase PF01633.20 EKE38269.1 - 0.019 14.6 1.4 0.032 13.8 0.2 2.0 2 1 0 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.14 EKE38269.1 - 0.12 11.7 0.0 0.46 9.8 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family TMF_TATA_bd PF12325.8 EKE38270.1 - 0.026 14.7 11.1 0.045 14.0 11.1 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding YabA PF06156.13 EKE38270.1 - 0.049 14.3 14.0 0.051 14.2 12.5 1.8 1 1 1 2 2 2 0 Initiation control protein YabA OmpH PF03938.14 EKE38270.1 - 0.38 11.1 20.2 0.54 10.6 20.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3450 PF11932.8 EKE38270.1 - 1.1 8.5 13.9 1.6 8.0 13.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF1843 PF08898.10 EKE38270.1 - 1.1 9.7 5.1 1.4 9.5 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) TMPIT PF07851.13 EKE38270.1 - 5.8 6.1 15.0 7.2 5.7 15.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein Inhibitor_I42 PF09394.10 EKE38271.1 - 5.7e-20 71.5 0.0 7e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Chagasin family peptidase inhibitor I42 PrcB_C PF14343.6 EKE38271.1 - 0.017 15.3 0.0 2.8 8.1 0.0 2.3 2 0 0 2 2 2 0 PrcB C-terminal Inhibitor_I71 PF12628.7 EKE38271.1 - 0.028 14.3 0.1 0.14 12.0 0.0 1.8 1 1 1 2 2 2 0 Falstatin, cysteine peptidase inhibitor Peptidase_C1 PF00112.23 EKE38272.1 - 1.9e-70 237.3 3.5 3.3e-70 236.6 3.5 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE38272.1 - 6.3e-07 29.7 4.5 6.3e-07 29.7 4.5 1.9 2 1 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EKE38272.1 - 7.2e-06 25.0 0.7 0.0039 16.0 0.1 2.3 2 0 0 2 2 2 2 Peptidase C1-like family Peptidase_C39_2 PF13529.6 EKE38272.1 - 0.0088 16.6 0.1 0.015 15.8 0.1 1.6 1 1 0 1 1 1 1 Peptidase_C39 like family F_actin_bund_C PF18060.1 EKE38273.1 - 6.8e-19 67.8 23.9 6.8e-19 67.8 23.9 3.4 2 1 1 3 3 3 1 F actin bundling C terminal Borrelia_P83 PF05262.11 EKE38273.1 - 1.8 6.9 34.1 2.5 6.5 34.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Arm-DNA-bind_4 PF14657.6 EKE38273.1 - 5.6 6.8 8.4 2.7 7.8 1.4 3.4 2 1 0 2 2 2 0 Arm DNA-binding domain SAPS PF04499.15 EKE38273.1 - 5.8 5.6 12.8 8 5.1 12.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NMT PF01233.19 EKE38274.1 - 1.5e-59 200.4 1.3 2.2e-59 199.9 0.0 1.9 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 EKE38274.1 - 1.1e-55 188.4 3.5 2.5e-55 187.2 3.5 1.5 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 EKE38274.1 - 0.00023 21.2 0.0 0.00055 20.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EKE38274.1 - 0.0017 18.6 0.0 0.0053 17.0 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family VPS9 PF02204.18 EKE38275.1 - 0.21 11.8 2.1 1.5 9.1 0.3 2.8 2 1 0 2 2 2 0 Vacuolar sorting protein 9 (VPS9) domain DUF3810 PF12725.7 EKE38275.1 - 0.75 9.1 5.9 0.35 10.2 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3810) Stealth_CR2 PF11380.8 EKE38276.1 - 1.3e-31 109.0 1.2 1.3e-31 109.0 1.2 3.2 3 1 0 3 3 3 2 Stealth protein CR2, conserved region 2 Stealth_CR1 PF17101.5 EKE38276.1 - 5.9e-10 38.7 1.2 1.2e-09 37.7 1.2 1.5 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Stealth_CR3 PF17102.5 EKE38276.1 - 2.8e-09 36.7 0.4 5.3e-09 35.8 0.4 1.5 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR4 PF17103.5 EKE38276.1 - 0.012 15.5 0.6 0.051 13.5 0.0 2.4 3 0 0 3 3 3 0 Stealth protein CR4, conserved region 4 PNTB PF02233.16 EKE38277.1 - 7.8e-09 35.0 0.4 7.8e-09 35.0 0.4 1.0 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit BAG PF02179.16 EKE38278.1 - 0.0075 16.7 5.8 0.014 15.9 5.8 1.5 1 1 0 1 1 1 1 BAG domain MSA-2c PF12238.8 EKE38278.1 - 3.8 7.5 5.8 4.1 7.3 5.8 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c RasGAP PF00616.19 EKE38279.1 - 0.057 13.1 10.9 0.39 10.4 1.5 3.0 2 1 2 4 4 4 0 GTPase-activator protein for Ras-like GTPase DSPc PF00782.20 EKE38280.1 - 1.9e-29 102.2 0.3 5.8e-29 100.6 0.0 2.0 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 EKE38280.1 - 7.4e-21 73.7 16.2 7.6e-11 41.6 0.6 2.6 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EKE38280.1 - 3.2e-14 52.8 31.3 1.8e-07 31.4 8.4 3.9 1 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EKE38280.1 - 3.2e-05 23.5 5.2 5.9e-05 22.6 5.2 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.33 EKE38280.1 - 5.3e-05 23.2 18.9 0.061 13.9 0.8 5.9 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.6 EKE38280.1 - 0.00017 21.4 26.3 0.28 11.4 0.7 5.0 5 0 0 5 5 5 3 Leucine Rich repeat Y_phosphatase PF00102.27 EKE38280.1 - 0.003 17.2 0.0 0.0046 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_5 PF13306.6 EKE38280.1 - 0.031 14.2 3.4 0.087 12.8 3.4 1.9 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) HU-CCDC81_bac_2 PF18175.1 EKE38280.1 - 0.11 12.4 0.1 0.26 11.2 0.1 1.7 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 CDC45 PF02724.14 EKE38281.1 - 0.13 10.6 13.1 0.18 10.0 13.1 1.3 1 0 0 1 1 1 0 CDC45-like protein BRO1 PF03097.18 EKE38284.1 - 1e-50 172.7 2.7 2.1e-50 171.7 2.7 1.5 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EKE38284.1 - 4.2e-17 62.4 17.7 8.4e-17 61.4 17.7 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV NTP_transf_4 PF13562.6 EKE38284.1 - 0.021 15.0 1.2 0.078 13.2 1.2 2.0 1 0 0 1 1 1 0 Sugar nucleotidyl transferase Erv26 PF04148.13 EKE38284.1 - 0.028 14.3 1.0 0.05 13.4 0.1 1.9 2 0 0 2 2 2 0 Transmembrane adaptor Erv26 DUF489 PF04356.12 EKE38284.1 - 1.9 8.5 6.8 0.41 10.6 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF489) BST2 PF16716.5 EKE38285.1 - 0.0059 17.2 12.9 0.0059 17.2 12.9 2.8 2 1 1 3 3 3 1 Bone marrow stromal antigen 2 HrpJ PF07201.11 EKE38285.1 - 0.034 14.4 14.6 0.053 13.8 14.6 1.3 1 0 0 1 1 1 0 HrpJ-like domain hDGE_amylase PF14701.6 EKE38285.1 - 0.086 11.9 18.4 0.1 11.6 18.4 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain ERM PF00769.19 EKE38285.1 - 1.1 9.0 36.9 2.9 7.6 36.9 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family ACR_tran PF00873.19 EKE38285.1 - 2 6.0 13.9 2.3 5.8 13.9 1.2 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family DUF2252 PF10009.9 EKE38285.1 - 2.4 7.2 10.2 3.1 6.8 10.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) SlyX PF04102.12 EKE38285.1 - 2.6 8.7 19.8 0.15 12.7 6.4 3.4 2 1 1 3 3 3 0 SlyX Herpes_UL6 PF01763.16 EKE38285.1 - 4 5.8 22.4 0.28 9.6 15.5 1.8 1 1 1 2 2 2 0 Herpesvirus UL6 like DUF2087 PF09860.9 EKE38285.1 - 4.2 7.6 7.7 12 6.1 2.0 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2087) DUF883 PF05957.13 EKE38285.1 - 4.3 8.0 8.2 1.9 9.2 4.5 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF724 PF05266.14 EKE38285.1 - 4.3 7.1 32.8 1.1 9.1 28.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF3492 PF11997.8 EKE38285.1 - 4.4 6.9 11.7 11 5.7 11.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3492) Golgin_A5 PF09787.9 EKE38285.1 - 4.5 6.7 37.9 1.1 8.7 24.0 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF1664 PF07889.12 EKE38285.1 - 5.6 7.0 29.8 1.5 8.9 12.5 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EKE38285.1 - 7.1 5.4 37.4 0.39 9.6 23.1 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.9 EKE38285.1 - 9.8 6.4 32.9 6.3 7.0 6.1 2.3 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 EKE38285.1 - 9.8 6.2 39.8 2.1 8.4 28.0 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Pmp3 PF01679.17 EKE38286.1 - 1.7e-13 50.5 8.8 2.3e-13 50.1 8.8 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Mpv17_PMP22 PF04117.12 EKE38286.1 - 0.015 15.5 0.6 0.021 15.0 0.6 1.2 1 0 0 1 1 1 0 Mpv17 / PMP22 family Prominin PF05478.11 EKE38286.1 - 0.1 10.5 0.8 0.15 10.0 0.8 1.2 1 0 0 1 1 1 0 Prominin SdpI PF13630.6 EKE38286.1 - 0.25 11.5 2.3 0.34 11.1 2.3 1.2 1 0 0 1 1 1 0 SdpI/YhfL protein family EIF_2_alpha PF07541.12 EKE38287.1 - 1.1e-27 96.4 0.0 2.3e-27 95.4 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EKE38287.1 - 1.5e-06 28.5 0.0 2.6e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain UCH PF00443.29 EKE38288.1 - 1e-42 146.4 0.3 1.2e-42 146.2 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE38288.1 - 7.7e-12 45.4 5.7 5.2e-07 29.6 1.0 2.2 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_4 PF18036.1 EKE38288.1 - 0.002 18.1 1.1 0.037 14.1 0.1 2.9 2 0 0 2 2 2 1 Ubiquitin-like domain USP7_C2 PF14533.6 EKE38288.1 - 0.021 14.5 1.3 0.067 12.9 0.8 1.9 1 1 1 2 2 2 0 Ubiquitin-specific protease C-terminal CBS PF00571.28 EKE38288.1 - 0.12 12.9 0.0 0.45 11.0 0.0 2.0 2 0 0 2 2 2 0 CBS domain Cep57_CLD_2 PF14197.6 EKE38289.1 - 0.021 14.9 4.8 0.021 14.9 4.8 2.5 4 0 0 4 4 4 0 Centrosome localisation domain of PPC89 HALZ PF02183.18 EKE38289.1 - 0.028 14.6 11.7 0.87 9.9 2.1 3.3 2 1 1 3 3 3 0 Homeobox associated leucine zipper Herpes_BLRF2 PF05812.12 EKE38289.1 - 0.32 11.1 6.2 1.5 8.9 0.1 3.0 3 0 0 3 3 3 0 Herpesvirus BLRF2 protein bZIP_1 PF00170.21 EKE38289.1 - 1.6 8.9 13.9 1.1 9.4 0.9 3.2 2 1 1 3 3 3 0 bZIP transcription factor Synaptobrevin PF00957.21 EKE38290.1 - 1.5e-27 95.2 8.5 2.1e-27 94.7 8.5 1.2 1 0 0 1 1 1 1 Synaptobrevin LMBR1 PF04791.16 EKE38290.1 - 6.3e-05 22.1 2.2 6.9e-05 22.0 2.2 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein GP41 PF00517.17 EKE38290.1 - 0.00015 21.8 2.5 0.00017 21.6 2.5 1.2 1 0 0 1 1 1 1 Retroviral envelope protein Baculo_F PF12259.8 EKE38290.1 - 0.00033 19.3 1.7 0.00035 19.3 1.7 1.1 1 0 0 1 1 1 1 Baculovirus F protein RIFIN PF02009.16 EKE38290.1 - 0.00066 19.7 6.4 0.00081 19.4 6.4 1.1 1 0 0 1 1 1 1 Rifin LAP1C PF05609.12 EKE38290.1 - 0.00096 18.4 1.4 0.0011 18.2 1.4 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) DUF2207 PF09972.9 EKE38290.1 - 0.0026 16.6 0.8 0.003 16.4 0.8 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Fzo_mitofusin PF04799.13 EKE38290.1 - 0.0056 16.2 3.2 0.0092 15.5 3.2 1.4 1 0 0 1 1 1 1 fzo-like conserved region DUF4199 PF13858.6 EKE38290.1 - 0.011 16.2 0.8 0.011 16.2 0.8 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4199) EVI2A PF05399.11 EKE38290.1 - 0.012 15.3 0.3 0.013 15.1 0.3 1.1 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) V_ATPase_I PF01496.19 EKE38290.1 - 0.014 13.4 3.5 0.016 13.1 3.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ndc1_Nup PF09531.10 EKE38290.1 - 0.025 13.3 0.1 0.03 13.0 0.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4635 PF15466.6 EKE38290.1 - 0.026 14.1 1.5 0.038 13.5 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) DUF3999 PF13163.6 EKE38290.1 - 0.041 13.1 0.1 0.06 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3999) MCU PF04678.13 EKE38290.1 - 0.043 13.9 1.4 0.06 13.4 1.4 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Snapin_Pallidin PF14712.6 EKE38290.1 - 0.054 13.9 5.0 0.065 13.6 4.4 1.5 1 1 0 1 1 1 0 Snapin/Pallidin SKN1 PF03935.15 EKE38290.1 - 0.094 11.1 0.2 0.15 10.4 0.1 1.4 1 1 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) TPPK_C PF12555.8 EKE38290.1 - 0.12 12.4 3.0 0.17 12.0 3.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal SLATT_5 PF18160.1 EKE38290.1 - 0.32 10.3 2.9 0.46 9.8 2.9 1.3 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Orf78 PF06024.12 EKE38290.1 - 0.36 11.1 6.8 1.6 9.0 6.8 2.0 1 1 0 1 1 1 0 Orf78 (ac78) EMP24_GP25L PF01105.24 EKE38290.1 - 0.44 10.5 5.1 0.68 9.8 5.1 1.4 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF5345 PF17280.2 EKE38290.1 - 0.47 10.5 5.2 0.11 12.4 0.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5345) T2SSF PF00482.23 EKE38290.1 - 1.6 8.7 4.4 3.9 7.4 4.4 1.8 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF2951 PF11166.8 EKE38290.1 - 2.5 8.4 13.5 0.32 11.2 7.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) DUF1664 PF07889.12 EKE38290.1 - 3.4 7.7 9.0 0.35 10.9 4.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Methyltr_RsmB-F PF01189.17 EKE38291.1 - 1.9e-43 148.5 0.1 1.2e-42 145.9 0.1 2.0 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EKE38291.1 - 2.3e-06 27.8 0.0 4.1e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 EKE38291.1 - 0.01 15.6 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EKE38291.1 - 0.016 14.5 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EKE38291.1 - 0.06 14.1 0.0 0.16 12.7 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain DED PF01335.21 EKE38291.1 - 0.24 11.7 2.5 3.9 7.8 0.5 2.9 2 0 0 2 2 2 0 Death effector domain DUF3744 PF12558.8 EKE38293.1 - 0.21 12.4 2.9 1.1 10.0 0.3 3.3 3 0 0 3 3 3 0 ATP-binding cassette cobalt transporter RasGEF PF00617.19 EKE38294.1 - 1.4e-05 25.4 0.0 5.1e-05 23.6 0.0 2.0 1 0 0 1 1 1 1 RasGEF domain SBDS_C PF09377.10 EKE38294.1 - 0.061 13.3 1.6 1.2 9.2 0.1 2.3 2 0 0 2 2 2 0 SBDS protein C-terminal domain ubiquitin PF00240.23 EKE38298.1 - 2.9e-10 39.8 0.0 4.9e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EKE38298.1 - 7.5e-09 35.3 2.4 1.5e-08 34.3 0.9 2.3 2 0 0 2 2 2 1 UBA/TS-N domain DUF2407 PF10302.9 EKE38298.1 - 8e-06 26.4 0.0 1.7e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain STI1 PF17830.1 EKE38298.1 - 0.00026 20.9 15.7 0.00026 20.9 15.7 3.4 2 1 1 3 3 3 1 STI1 domain Rad60-SLD PF11976.8 EKE38298.1 - 0.0042 16.9 0.1 0.094 12.6 0.0 2.4 1 1 1 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.5 EKE38298.1 - 0.0089 16.0 0.2 0.03 14.3 0.0 1.8 2 0 0 2 2 2 1 HOIP UBA domain pair CUE PF02845.16 EKE38298.1 - 0.012 15.3 0.5 0.17 11.6 0.1 2.7 2 0 0 2 2 2 0 CUE domain Rad60-SLD_2 PF13881.6 EKE38298.1 - 0.037 14.1 0.0 0.086 13.0 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like UBA_4 PF14555.6 EKE38298.1 - 0.13 12.1 0.1 0.65 9.9 0.0 2.1 2 0 0 2 2 2 0 UBA-like domain Pox_A3L PF05288.11 EKE38298.1 - 0.18 11.8 4.1 1.2 9.2 1.0 3.3 3 1 1 4 4 4 0 Poxvirus A3L Protein TFIIA PF03153.13 EKE38298.1 - 5.6 6.9 22.9 7.2 6.5 22.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IF-2B PF01008.17 EKE38299.1 - 0.03 13.5 0.1 0.038 13.2 0.1 1.2 1 0 0 1 1 1 0 Initiation factor 2 subunit family LIM PF00412.22 EKE38300.1 - 4.4e-61 203.0 33.7 9.4e-16 57.8 0.7 4.2 4 0 0 4 4 4 4 LIM domain DUF3725 PF12523.8 EKE38300.1 - 0.012 15.9 4.0 7.3 7.0 0.3 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3725) zf_C2H2_13 PF18508.1 EKE38300.1 - 0.016 14.8 32.0 1.3 8.6 0.2 7.2 6 1 1 7 7 7 0 Zinc finger domain zf-dskA_traR PF01258.17 EKE38300.1 - 0.049 13.6 32.8 0.12 12.4 0.3 8.1 7 2 1 8 8 8 0 Prokaryotic dksA/traR C4-type zinc finger FUSC PF04632.12 EKE38300.1 - 0.08 11.5 0.0 0.72 8.3 0.0 1.9 2 0 0 2 2 2 0 Fusaric acid resistance protein family ROS_MUCR PF05443.11 EKE38300.1 - 0.43 10.6 3.0 8 6.5 2.5 2.8 1 1 1 2 2 2 0 ROS/MUCR transcriptional regulator protein Unstab_antitox PF09720.10 EKE38300.1 - 0.69 10.0 4.7 44 4.2 0.1 3.6 2 1 1 3 3 3 0 Putative addiction module component Zn_ribbon_recom PF13408.6 EKE38300.1 - 0.85 10.2 27.2 1.8 9.2 0.1 5.7 5 0 0 5 5 5 0 Recombinase zinc beta ribbon domain zf_UBZ PF18439.1 EKE38300.1 - 0.94 9.1 39.6 3.6 7.3 1.3 8.5 9 0 0 9 9 9 0 Ubiquitin-Binding Zinc Finger Sgf11 PF08209.11 EKE38300.1 - 0.96 9.1 0.0 0.96 9.1 0.0 6.7 8 0 0 8 8 8 0 Sgf11 (transcriptional regulation protein) zf-ribbon_3 PF13248.6 EKE38300.1 - 3.6 7.1 39.7 1.8 8.1 0.7 7.5 8 0 0 8 8 8 0 zinc-ribbon domain DnaJ_C PF01556.18 EKE38301.1 - 5.8e-30 104.3 0.5 1.1e-29 103.5 0.5 1.5 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EKE38301.1 - 2.2e-24 85.4 2.7 3.6e-24 84.7 2.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EKE38301.1 - 3.8e-13 49.6 19.5 6.3e-13 48.9 19.5 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EKE38301.1 - 0.0002 21.3 16.6 0.03 14.3 5.9 2.4 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein DUF3365 PF11845.8 EKE38301.1 - 0.032 14.6 1.0 8.9 6.6 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) zf_CopZ PF18423.1 EKE38301.1 - 0.13 12.3 12.2 5.3 7.1 0.1 3.8 2 1 1 3 3 3 0 Zinc binding domain Cytochrome_CBB3 PF13442.6 EKE38301.1 - 0.28 11.5 0.0 0.28 11.5 0.0 2.8 2 1 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III HypA PF01155.19 EKE38301.1 - 0.29 11.2 12.1 0.32 11.0 1.2 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 EKE38301.1 - 0.34 11.3 9.6 1.3 9.4 6.6 3.2 2 1 1 3 3 3 0 Restriction alleviation protein Lar TackOD1 PF18551.1 EKE38301.1 - 0.42 10.3 10.5 0.94 9.1 1.9 2.1 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 DZR PF12773.7 EKE38301.1 - 1.3 9.2 10.7 3.2 7.8 10.7 1.7 1 1 0 1 1 1 0 Double zinc ribbon Haem_bd PF14376.6 EKE38301.1 - 5.6 6.9 6.1 2.5 8.0 0.3 2.9 3 0 0 3 3 3 0 Haem-binding domain Cytochrom_c3_2 PF14537.6 EKE38301.1 - 5.8 7.5 14.0 16 6.0 13.8 1.7 1 1 0 1 1 1 0 Cytochrome c3 Zn-ribbon_8 PF09723.10 EKE38301.1 - 7 6.9 16.3 9.8 6.4 4.7 4.0 1 1 3 4 4 4 0 Zinc ribbon domain PWWP PF00855.17 EKE38302.1 - 1.7e-14 54.0 1.6 1.7e-14 54.0 1.6 2.6 2 1 1 3 3 3 1 PWWP domain CWC25 PF12542.8 EKE38302.1 - 0.41 11.6 6.2 0.076 13.9 1.4 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing factor Ras PF00071.22 EKE38303.1 - 9.2e-06 25.3 0.1 1.2e-05 25.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38303.1 - 0.0038 17.4 0.3 0.0038 17.4 0.3 2.0 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EKE38303.1 - 0.0045 16.9 0.1 2.2 8.2 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE38303.1 - 0.023 14.8 0.1 0.049 13.7 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase MlaC PF05494.12 EKE38303.1 - 0.026 14.3 0.1 0.058 13.1 0.1 1.6 1 1 0 1 1 1 0 MlaC protein YIF1 PF03878.15 EKE38305.1 - 1.3e-21 77.2 11.4 1.9e-21 76.7 11.4 1.2 1 0 0 1 1 1 1 YIF1 Methyltr_RsmB-F PF01189.17 EKE38306.1 - 1.5e-31 109.6 0.0 2.7e-31 108.8 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EKE38306.1 - 0.00064 19.9 0.0 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 EKE38306.1 - 0.0098 16.6 0.0 0.025 15.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Shikimate_DH PF01488.20 EKE38306.1 - 0.013 15.6 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Peptidase_C47 PF05543.13 EKE38306.1 - 0.058 13.0 1.0 0.11 12.0 0.2 1.9 2 0 0 2 2 2 0 Staphopain peptidase C47 Myotub-related PF06602.14 EKE38307.1 - 6.1e-56 189.9 5.7 5.3e-54 183.5 5.7 2.2 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain PP2C PF00481.21 EKE38308.1 - 1.2e-41 143.1 0.1 2.7e-27 96.1 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C LRR_4 PF12799.7 EKE38308.1 - 2.4e-26 91.3 103.2 7.5e-06 26.2 0.4 14.4 5 3 6 13 13 13 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE38308.1 - 2.7e-21 75.1 78.6 2.5e-07 30.4 1.7 10.8 5 3 6 11 11 11 9 Leucine rich repeat LRR_5 PF13306.6 EKE38308.1 - 4.1e-05 23.5 8.9 4.1e-05 23.5 8.9 5.4 2 2 3 5 5 5 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EKE38308.1 - 0.00056 19.5 36.7 0.097 12.2 0.1 5.9 1 1 3 6 6 6 4 Leucine-rich repeat PP2C_2 PF13672.6 EKE38308.1 - 0.017 14.8 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein phosphatase 2C APC_r PF05923.12 EKE38308.1 - 0.31 10.8 4.8 0.15 11.8 0.7 2.4 2 0 0 2 2 2 0 APC repeat Apis_Csd PF11671.8 EKE38308.1 - 2.6 8.0 4.3 2.1 8.3 0.1 2.6 2 0 0 2 2 2 0 Complementary sex determiner protein MFS_1 PF07690.16 EKE38309.1 - 6e-25 87.9 38.9 1.7e-23 83.2 36.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EKE38309.1 - 8.9e-12 44.6 6.7 8.9e-12 44.6 6.7 3.0 3 1 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EKE38309.1 - 4.9e-05 21.9 5.2 4.9e-05 21.9 5.2 1.9 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF3328 PF11807.8 EKE38309.1 - 0.043 13.6 1.4 0.062 13.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) T6SS-SciN PF12790.7 EKE38310.1 - 0.023 14.4 0.4 0.058 13.1 0.4 1.6 1 0 0 1 1 1 0 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 EOS1 PF12326.8 EKE38310.1 - 0.16 11.9 3.2 0.55 10.1 3.2 1.9 1 1 0 1 1 1 0 N-glycosylation protein DUF2244 PF10003.9 EKE38310.1 - 0.47 10.1 2.0 0.74 9.5 0.1 2.1 1 1 2 3 3 3 0 Integral membrane protein (DUF2244) DUF2070 PF09843.9 EKE38310.1 - 4.4 5.5 8.8 7.7 4.7 8.8 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Alpha_kinase PF02816.18 EKE38311.1 - 7.3e-45 153.3 8.0 7.3e-45 153.3 8.0 2.0 2 0 0 2 2 2 1 Alpha-kinase family N6-adenineMlase PF10237.9 EKE38312.1 - 3.9e-43 147.0 1.5 4.8e-43 146.7 1.5 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase DUF43 PF01861.16 EKE38312.1 - 0.1 11.8 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Cons_hypoth95 PF03602.15 EKE38312.1 - 0.17 11.5 0.1 0.26 10.9 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 AAA PF00004.29 EKE38313.1 - 1.5e-41 141.9 0.0 5.2e-39 133.7 0.0 3.5 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKE38313.1 - 5e-08 32.6 0.0 1.2e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EKE38313.1 - 3e-06 27.6 0.3 0.015 15.5 0.0 3.5 2 1 1 3 3 3 2 AAA domain RuvB_N PF05496.12 EKE38313.1 - 1.8e-05 24.5 0.0 4.8e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EKE38313.1 - 3.4e-05 23.4 0.1 0.00018 21.1 0.1 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 EKE38313.1 - 0.00017 22.0 0.2 0.024 15.0 0.0 3.1 2 1 1 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 EKE38313.1 - 0.00023 21.2 0.3 0.0013 18.7 0.1 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EKE38313.1 - 0.00025 21.2 0.0 0.0064 16.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 EKE38313.1 - 0.00035 20.5 0.3 0.0035 17.2 0.0 2.6 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_14 PF13173.6 EKE38313.1 - 0.00054 20.0 0.0 0.0013 18.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EKE38313.1 - 0.00062 19.5 0.0 0.0018 18.1 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_24 PF13479.6 EKE38313.1 - 0.0019 18.0 0.0 0.0061 16.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EKE38313.1 - 0.0029 17.7 0.5 0.017 15.3 0.0 2.6 3 1 0 3 3 2 1 AAA domain (Cdc48 subfamily) TniB PF05621.11 EKE38313.1 - 0.0048 16.3 1.1 1.6 8.1 0.0 3.0 2 1 1 3 3 3 2 Bacterial TniB protein Mg_chelatase PF01078.21 EKE38313.1 - 0.005 16.2 0.0 0.012 15.0 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EKE38313.1 - 0.0075 16.8 0.0 0.0075 16.8 0.0 2.9 4 0 0 4 4 2 1 AAA domain TIP49 PF06068.13 EKE38313.1 - 0.017 14.3 3.3 0.025 13.8 0.1 2.4 2 1 1 3 3 3 0 TIP49 P-loop domain SH3_15 PF18346.1 EKE38313.1 - 0.018 15.4 0.0 0.073 13.4 0.0 2.0 2 0 0 2 2 1 0 Mind bomb SH3 repeat domain Guanylate_kin PF00625.21 EKE38313.1 - 0.037 13.7 0.6 8 6.1 0.0 3.6 3 0 0 3 3 3 0 Guanylate kinase RNA_helicase PF00910.22 EKE38313.1 - 0.056 13.8 0.0 0.26 11.7 0.0 2.3 2 0 0 2 2 1 0 RNA helicase Sigma54_activat PF00158.26 EKE38313.1 - 0.082 12.6 0.0 0.22 11.2 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain TPR_MalT PF17874.1 EKE38313.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 MalT-like TPR region AAA_28 PF13521.6 EKE38313.1 - 0.11 12.8 0.1 0.35 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Latarcin PF10279.9 EKE38313.1 - 0.47 10.9 0.0 0.47 10.9 0.0 3.0 4 0 0 4 4 2 0 Latarcin precursor AAA_17 PF13207.6 EKE38313.1 - 1.6 9.2 5.3 1.8 9.0 0.0 3.4 4 0 0 4 4 3 0 AAA domain DUF2935 PF11155.8 EKE38313.1 - 6.7 7.1 7.2 5.9 7.2 0.2 3.3 4 0 0 4 4 3 0 Domain of unknown function (DUF2935) His_Phos_2 PF00328.22 EKE38315.1 - 6.9e-21 75.0 0.1 2e-19 70.2 0.1 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF4883 PF16224.5 EKE38315.1 - 0.031 14.5 0.6 2.1 8.6 0.1 2.7 2 0 0 2 2 2 0 DOmain of unknown function (DUF4883) SAM_1 PF00536.30 EKE38316.1 - 0.051 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EKE38316.1 - 0.068 13.3 0.1 0.21 11.7 0.1 1.8 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Abhydrolase_3 PF07859.13 EKE38316.1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EKE38316.1 - 0.23 10.7 0.1 1.3 8.2 0.1 1.9 1 1 1 2 2 2 0 Serine aminopeptidase, S33 zf-MIZ PF02891.20 EKE38317.1 - 1.9e-07 30.7 8.6 4.1e-07 29.6 8.6 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EKE38317.1 - 1.1e-05 25.2 1.0 1.1e-05 25.2 1.0 2.2 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EKE38317.1 - 0.044 13.8 1.9 0.12 12.4 1.9 1.8 1 1 0 1 1 1 0 RING-type zinc-finger Cnd1 PF12717.7 EKE38318.1 - 2.1e-42 144.9 11.8 9.6e-41 139.5 0.0 4.4 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKE38318.1 - 3.6e-07 30.5 0.2 0.00072 19.9 0.0 4.6 5 1 0 5 5 5 1 HEAT repeats HEAT PF02985.22 EKE38318.1 - 7.1e-07 29.0 0.8 0.79 10.1 0.0 5.4 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 EKE38318.1 - 0.0024 18.3 0.2 4.7 7.8 0.0 4.7 4 0 0 4 4 4 1 HEAT-like repeat DUF4209 PF13910.6 EKE38318.1 - 0.013 15.7 0.3 2.9 8.2 0.0 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4209) Cohesin_HEAT PF12765.7 EKE38318.1 - 0.081 13.2 1.5 4 7.8 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Ribos_L4_asso_C PF14374.6 EKE38318.1 - 0.11 12.5 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 60S ribosomal protein L4 C-terminal domain RTP1_C1 PF10363.9 EKE38318.1 - 0.15 12.3 0.9 7.4 6.8 0.1 3.9 2 2 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 DNA_alkylation PF08713.11 EKE38319.1 - 8.4e-54 182.5 0.0 1e-53 182.2 0.0 1.1 1 0 0 1 1 1 1 DNA alkylation repair enzyme NUC130_3NT PF08158.12 EKE38319.1 - 0.12 12.7 0.2 2.6 8.4 0.0 3.1 3 1 0 3 3 3 0 NUC130/3NT domain TPR_MalT PF17874.1 EKE38320.1 - 0.044 13.1 0.0 1.1 8.5 0.0 2.4 2 0 0 2 2 2 0 MalT-like TPR region SNF2_N PF00176.23 EKE38321.1 - 2.9e-25 88.8 0.3 2.9e-25 88.8 0.3 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE38321.1 - 7.2e-14 52.1 0.2 5.9e-13 49.1 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE38321.1 - 5.9e-07 29.6 0.0 5.9e-07 29.6 0.0 3.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_assoc PF14363.6 EKE38322.1 - 0.046 14.1 0.8 0.16 12.4 0.8 1.9 1 0 0 1 1 1 0 Domain associated at C-terminal with AAA GLYCAM-1 PF05242.11 EKE38322.1 - 0.13 12.4 15.4 0.37 10.9 15.2 1.9 1 1 0 1 1 1 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) malic PF00390.19 EKE38323.1 - 0.087 12.6 0.3 0.19 11.5 0.1 1.7 2 0 0 2 2 2 0 Malic enzyme, N-terminal domain SF3A3 PF16837.5 EKE38323.1 - 0.21 12.1 5.6 1.9 9.0 0.2 2.8 3 0 0 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 NAP PF00956.18 EKE38324.1 - 3e-19 69.3 1.5 2.2e-13 50.0 0.0 2.1 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) DUF3902 PF13042.6 EKE38324.1 - 0.021 14.4 0.1 1.4 8.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3902) DUF4130 PF13566.6 EKE38324.1 - 0.027 14.5 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4130 zf-RING_5 PF14634.6 EKE38325.1 - 0.032 14.2 11.2 0.032 14.2 11.2 4.0 3 1 0 3 3 3 0 zinc-RING finger domain C2 PF00168.30 EKE38326.1 - 2e-15 56.9 0.1 3.7e-15 56.1 0.1 1.4 1 0 0 1 1 1 1 C2 domain TLD PF07534.16 EKE38326.1 - 0.0093 16.2 1.3 0.019 15.2 1.3 1.5 1 0 0 1 1 1 1 TLD Beta_propel PF09826.9 EKE38326.1 - 0.12 11.2 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Beta propeller domain G_path_suppress PF15991.5 EKE38326.1 - 1.5 8.9 13.3 2.3 8.3 13.3 1.2 1 0 0 1 1 1 0 G-protein pathway suppressor RRM_1 PF00076.22 EKE38327.1 - 5.1e-17 61.5 2.1 7.6e-12 44.9 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EKE38327.1 - 4.9e-06 26.5 0.9 5.3e-05 23.2 0.2 2.1 2 0 0 2 2 2 1 RNA binding motif RRM_7 PF16367.5 EKE38327.1 - 0.00023 21.2 0.4 1.1 9.4 0.2 2.6 2 1 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 EKE38327.1 - 0.002 17.7 0.1 0.0031 17.1 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NKWYS PF10364.9 EKE38327.1 - 0.0072 16.5 2.3 0.0072 16.5 2.3 2.0 1 1 0 2 2 2 1 Putative capsular polysaccharide synthesis protein FTP PF07504.13 EKE38327.1 - 0.1 12.4 0.0 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 Fungalysin/Thermolysin Propeptide Motif LIM PF00412.22 EKE38328.1 - 5e-23 81.1 25.9 7.1e-12 45.4 4.5 3.5 3 1 0 3 3 3 2 LIM domain DZR PF12773.7 EKE38328.1 - 0.00016 21.7 30.7 0.034 14.2 9.0 4.7 1 1 2 3 3 3 1 Double zinc ribbon XPA_N PF01286.18 EKE38328.1 - 0.004 17.2 0.8 0.07 13.2 0.4 6.0 6 2 1 7 7 7 2 XPA protein N-terminal zinc_ribbon_2 PF13240.6 EKE38328.1 - 0.023 14.4 7.5 0.023 14.4 7.5 7.0 6 2 1 7 7 7 0 zinc-ribbon domain zf-C2H2 PF00096.26 EKE38328.1 - 0.12 12.9 0.1 0.12 12.9 0.1 6.1 8 0 0 8 8 8 0 Zinc finger, C2H2 type Nudix_N_2 PF14803.6 EKE38328.1 - 0.37 10.7 0.1 0.37 10.7 0.1 6.3 6 1 0 6 6 6 0 Nudix N-terminal ROS_MUCR PF05443.11 EKE38328.1 - 0.75 9.9 4.8 0.48 10.5 0.7 2.8 3 1 0 3 3 3 0 ROS/MUCR transcriptional regulator protein RNA_pol_N PF01194.17 EKE38328.1 - 3.3 8.1 0.0 3.3 8.1 0.0 4.2 5 0 0 5 5 5 0 RNA polymerases N / 8 kDa subunit zf-ribbon_3 PF13248.6 EKE38328.1 - 8 6.0 38.4 1.3 8.5 0.3 7.5 7 1 0 8 8 8 0 zinc-ribbon domain Cloacin_immun PF03513.14 EKE38329.1 - 0.014 15.7 0.4 0.052 13.9 0.4 2.0 1 0 0 1 1 1 0 Cloacin immunity protein Imm32 PF15566.6 EKE38329.1 - 0.2 11.5 1.9 2.3 8.1 0.1 2.6 2 0 0 2 2 2 0 Immunity protein 32 Calpain_III PF01067.22 EKE38329.1 - 0.46 10.7 10.0 0.15 12.3 3.4 2.4 1 1 1 2 2 2 0 Calpain large subunit, domain III RNA_pol_3_Rpc31 PF11705.8 EKE38329.1 - 3.1 8.0 6.7 0.24 11.6 0.2 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Ras PF00071.22 EKE38330.1 - 1.6e-15 57.1 0.0 2e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38330.1 - 1.6e-09 38.0 0.0 3e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EKE38330.1 - 0.0018 17.8 0.0 0.0077 15.8 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE38330.1 - 0.01 15.9 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 EKE38330.1 - 0.012 15.3 0.1 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EKE38330.1 - 0.02 14.8 0.0 3.1 7.7 0.0 2.4 1 1 1 2 2 2 0 RsgA GTPase ATP_bind_1 PF03029.17 EKE38330.1 - 0.022 14.6 0.0 3.3 7.4 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EKE38330.1 - 0.086 13.1 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EKE38330.1 - 0.11 12.2 0.0 11 5.8 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AROS PF15684.5 EKE38330.1 - 7.7 7.1 5.5 0.46 11.1 0.3 1.6 2 0 0 2 2 2 0 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 CorA PF01544.18 EKE38331.1 - 4.4e-46 157.5 6.1 4.4e-46 157.5 6.1 1.4 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 EKE38331.1 - 0.00045 19.1 3.8 0.00079 18.3 3.8 1.4 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Glyco_tranf_2_2 PF10111.9 EKE38331.1 - 0.01 15.3 0.6 0.54 9.7 0.1 2.3 1 1 1 2 2 2 0 Glycosyltransferase like family 2 Transposase_21 PF02992.14 EKE38331.1 - 0.11 11.8 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Transposase family tnp2 T2SSF PF00482.23 EKE38331.1 - 0.28 11.1 3.2 1.3 8.9 0.0 2.5 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F IZUMO PF15005.6 EKE38331.1 - 0.31 11.5 1.7 0.62 10.6 1.7 1.5 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated PP2C PF00481.21 EKE38332.1 - 7.1e-65 219.2 0.0 3.7e-64 216.8 0.0 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE38332.1 - 0.0066 16.1 0.0 0.012 15.2 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C DUF4298 PF14131.6 EKE38332.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) Pkinase_Tyr PF07714.17 EKE38333.1 - 1.3e-12 47.5 0.1 2.2e-12 46.8 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38333.1 - 2.3e-12 46.9 2.9 4.2e-12 46.0 1.1 2.1 2 0 0 2 2 2 1 Protein kinase domain Pox_polyA_pol_N PF12630.7 EKE38333.1 - 0.012 16.0 5.3 1.3 9.4 0.1 3.3 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain Kinase-like PF14531.6 EKE38333.1 - 0.024 14.0 0.0 0.055 12.8 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Ribosomal_L19e PF01280.20 EKE38334.1 - 9.4e-52 174.9 7.2 1.5e-51 174.3 7.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L19e Thioredoxin PF00085.20 EKE38335.1 - 7.4e-35 119.0 4.7 9.3e-28 96.2 0.1 3.4 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EKE38335.1 - 4.2e-23 82.2 18.4 1.9e-10 41.0 1.3 3.5 2 1 1 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 EKE38335.1 - 2e-05 24.1 0.5 0.0058 16.0 0.0 2.7 2 1 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EKE38335.1 - 0.0026 18.2 0.2 0.012 16.0 0.1 2.3 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EKE38335.1 - 0.0057 17.0 4.6 0.13 12.6 0.1 4.3 4 1 1 5 5 5 1 Thioredoxin-like Clavanin PF05452.11 EKE38335.1 - 0.03 14.5 0.2 0.49 10.6 0.1 2.7 2 0 0 2 2 2 0 Clavanin LPD34 PF18852.1 EKE38335.1 - 0.035 13.7 0.1 0.083 12.5 0.1 1.7 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 Thioredoxin_3 PF13192.6 EKE38335.1 - 0.078 13.0 0.1 0.24 11.5 0.1 1.9 1 0 0 1 1 1 0 Thioredoxin domain Glutaredoxin PF00462.24 EKE38335.1 - 0.28 11.4 3.2 0.33 11.2 0.2 2.4 2 0 0 2 2 2 0 Glutaredoxin TraF PF13728.6 EKE38335.1 - 0.86 9.4 6.6 5.2 6.8 0.0 3.8 3 1 0 4 4 4 0 F plasmid transfer operon protein RecG_wedge PF17191.4 EKE38336.1 - 0.0085 15.7 0.0 0.01 15.5 0.0 1.1 1 0 0 1 1 1 1 RecG wedge domain zf-CCCH PF00642.24 EKE38337.1 - 3.1e-16 58.8 16.7 4e-08 33.0 3.1 2.2 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EKE38337.1 - 8.6e-13 47.9 20.7 1.8e-06 27.8 6.3 2.3 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 EKE38337.1 - 2.7e-10 40.9 7.4 2.8e-05 24.8 0.6 2.2 1 1 1 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 EKE38337.1 - 1.7e-08 34.0 16.6 1e-06 28.4 4.6 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EKE38337.1 - 1e-05 25.7 10.7 0.016 15.4 1.8 2.2 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_2 PF14608.6 EKE38337.1 - 0.00026 21.3 17.6 0.045 14.3 4.6 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger EF1G PF00647.19 EKE38338.1 - 1.1e-36 125.1 0.4 1.1e-36 125.1 0.4 1.4 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain Not3 PF04065.15 EKE38339.1 - 1.4e-53 181.7 33.1 1.4e-53 181.7 33.1 2.7 1 1 2 3 3 3 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EKE38339.1 - 9.7e-21 74.2 11.6 9.7e-21 74.2 11.6 3.6 3 1 1 5 5 5 1 NOT2 / NOT3 / NOT5 family DUF2004 PF09406.10 EKE38339.1 - 3.1 8.2 12.4 1.6 9.1 4.7 3.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2004) DER1 PF04511.15 EKE38340.1 - 5.5e-32 111.3 17.8 6.8e-32 110.9 17.8 1.0 1 0 0 1 1 1 1 Der1-like family DUF1751 PF08551.10 EKE38340.1 - 0.022 15.3 1.4 0.022 15.3 1.4 2.6 2 1 1 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) UPF0242 PF06785.11 EKE38340.1 - 0.1 12.7 1.3 0.17 12.0 0.5 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Rhomboid PF01694.22 EKE38340.1 - 3.1 7.8 10.0 1 9.3 6.0 2.2 2 1 0 2 2 2 0 Rhomboid family Mod_r PF07200.13 EKE38341.1 - 0.0091 16.1 6.2 0.0091 16.1 6.2 1.9 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein Atg14 PF10186.9 EKE38341.1 - 0.051 12.7 6.4 0.07 12.2 6.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 G-gamma PF00631.22 EKE38341.1 - 0.41 10.7 2.4 1.3 9.1 2.4 1.8 2 0 0 2 2 2 0 GGL domain Alpha-amylase PF00128.24 EKE38342.1 - 6.8e-06 25.9 0.2 6.4e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 Alpha amylase, catalytic domain MIP-T3 PF10243.9 EKE38345.1 - 0.061 13.3 0.2 1 9.4 0.1 2.9 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 CH-like domain zf-ZPR1 PF03367.13 EKE38346.1 - 2.2e-98 326.6 1.0 3.5e-50 170.0 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Sigma_1_2 PF03084.14 EKE38346.1 - 0.1 11.8 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Reoviral Sigma1/Sigma2 family RNA_POL_M_15KD PF02150.16 EKE38346.1 - 0.85 9.5 4.3 2.4 8.1 0.9 3.2 2 1 0 2 2 2 0 RNA polymerases M/15 Kd subunit Rubredoxin_2 PF18073.1 EKE38346.1 - 4.6 7.1 9.6 9 6.1 0.5 3.3 3 0 0 3 3 3 0 Rubredoxin metal binding domain Ribosomal_L32p PF01783.23 EKE38346.1 - 8.5 6.7 6.7 2.1 8.7 0.2 2.8 2 2 1 3 3 3 0 Ribosomal L32p protein family Ribosomal_S7e PF01251.18 EKE38347.1 - 1.2e-33 116.4 5.0 1.5e-33 116.1 5.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7e CodY PF06018.14 EKE38347.1 - 0.023 14.2 0.2 0.035 13.6 0.2 1.3 1 0 0 1 1 1 0 CodY GAF-like domain PPP4R2 PF09184.11 EKE38348.1 - 4.1 6.9 16.8 4.4 6.8 16.8 1.1 1 0 0 1 1 1 0 PPP4R2 BUD22 PF09073.10 EKE38348.1 - 8.5 5.6 18.8 9.1 5.5 18.8 1.1 1 0 0 1 1 1 0 BUD22 Peptidase_C12 PF01088.21 EKE38350.1 - 1e-54 185.5 0.3 2e-54 184.5 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EKE38350.1 - 1.1e-08 34.8 3.2 3.3e-08 33.3 3.2 1.9 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Tam41_Mmp37 PF09139.11 EKE38350.1 - 1.1 8.6 5.8 0.41 10.0 3.3 1.5 2 0 0 2 2 2 0 Phosphatidate cytidylyltransferase, mitochondrial WD40 PF00400.32 EKE38351.1 - 2.5e-06 28.1 1.8 0.00071 20.3 0.5 3.7 3 1 0 3 3 3 2 WD domain, G-beta repeat DUF3150 PF11348.8 EKE38352.1 - 0.017 14.4 5.1 0.017 14.4 5.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3150) DUF4407 PF14362.6 EKE38352.1 - 0.32 10.3 12.5 0.4 10.0 12.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TraG-D_C PF12696.7 EKE38353.1 - 0.027 14.5 0.5 0.072 13.1 0.3 1.8 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG Stirrup PF09061.6 EKE38353.1 - 0.07 13.3 0.6 3.2 8.0 0.1 2.5 2 0 0 2 2 2 0 Stirrup Fes1 PF08609.10 EKE38354.1 - 9.2e-08 32.9 1.4 1.8e-07 31.9 1.4 1.6 1 0 0 1 1 1 1 Nucleotide exchange factor Fes1 DUF3232 PF11554.8 EKE38354.1 - 0.0054 17.1 2.1 0.0055 17.1 0.6 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3232) CTNNBL PF08216.11 EKE38354.1 - 0.015 15.4 1.6 0.073 13.2 0.7 2.2 2 0 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear Imm5 PF14423.6 EKE38354.1 - 0.39 10.9 5.0 0.11 12.7 1.2 2.0 2 1 0 2 2 2 0 Immunity protein Imm5 Colicin_immun PF09204.10 EKE38354.1 - 0.4 11.3 5.8 2.1 9.0 0.8 2.6 2 0 0 2 2 2 0 Bacterial self-protective colicin-like immunity Pkinase_Tyr PF07714.17 EKE38355.1 - 2e-51 174.8 0.0 5.6e-51 173.3 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38355.1 - 3.3e-49 167.6 0.0 6.7e-49 166.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain VSP PF03302.13 EKE38355.1 - 1.2e-07 31.0 587.8 0.015 14.2 39.4 18.1 2 2 14 16 16 16 12 Giardia variant-specific surface protein Pkinase_fungal PF17667.1 EKE38355.1 - 5.4e-06 25.4 0.0 9.4e-06 24.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase TMEM154 PF15102.6 EKE38355.1 - 0.28 11.1 0.9 0.61 10.0 0.9 1.5 1 0 0 1 1 1 0 TMEM154 protein family OAD_gamma PF04277.13 EKE38355.1 - 3.7 8.2 4.8 6.9 7.3 4.8 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Pkinase_Tyr PF07714.17 EKE38356.1 - 7e-17 61.6 0.2 1.3e-16 60.7 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38356.1 - 7e-14 51.8 0.2 1.2e-13 51.1 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain VSP PF03302.13 EKE38356.1 - 2.3e-06 26.7 172.0 3.9e-05 22.7 38.0 6.8 1 1 3 4 4 4 3 Giardia variant-specific surface protein TMEM154 PF15102.6 EKE38356.1 - 0.015 15.2 0.1 0.034 14.1 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 EKE38356.1 - 0.038 14.9 0.0 0.11 13.3 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 EKE38356.1 - 0.08 13.2 0.3 0.66 10.3 0.1 2.2 2 0 0 2 2 2 0 Orf78 (ac78) DUF4330 PF14221.6 EKE38356.1 - 0.1 12.8 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) LRR19-TM PF15176.6 EKE38356.1 - 0.15 12.1 2.5 0.49 10.4 2.5 1.9 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF2207 PF09972.9 EKE38356.1 - 0.18 10.5 1.4 0.3 9.8 1.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF5385 PF17359.2 EKE38356.1 - 0.69 9.4 3.9 1.5 8.4 3.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5385) ASFV_J13L PF05568.11 EKE38356.1 - 1.5 8.6 3.2 2.6 7.7 3.2 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Metallophos_2 PF12850.7 EKE38357.1 - 5e-23 82.1 0.0 5.9e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EKE38357.1 - 0.00053 20.5 0.9 0.091 13.3 0.9 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Leader_Erm PF08253.11 EKE38358.1 - 0.12 12.6 0.7 0.52 10.7 0.7 2.1 1 0 0 1 1 1 0 Erm Leader peptide Cation_efflux PF01545.21 EKE38359.1 - 7.2e-19 68.3 17.5 9e-19 68.0 17.5 1.1 1 0 0 1 1 1 1 Cation efflux family VSP PF03302.13 EKE38361.1 - 0.07 12.0 63.3 0.055 12.3 14.9 2.8 1 1 1 2 2 2 0 Giardia variant-specific surface protein CobS PF02654.15 EKE38364.1 - 0.012 15.9 2.9 0.022 15.0 1.8 1.8 2 0 0 2 2 2 0 Cobalamin-5-phosphate synthase DUF5455 PF17537.2 EKE38364.1 - 0.085 13.3 3.4 4.4 7.8 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5455) AlphaC_C PF17480.2 EKE38365.1 - 0.017 15.1 0.6 0.061 13.3 0.5 2.0 1 1 0 1 1 1 0 AlphaC C-terminal Cullin PF00888.22 EKE38366.1 - 1.8e-67 228.4 18.1 2.3e-67 228.0 18.1 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EKE38366.1 - 9.7e-14 51.2 1.2 9.7e-14 51.2 1.2 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain SpecificRecomb PF10136.9 EKE38367.1 - 0.0023 16.3 0.2 0.0027 16.1 0.2 1.1 1 0 0 1 1 1 1 Site-specific recombinase Mog1 PF04603.12 EKE38367.1 - 0.39 11.1 6.5 0.2 12.0 4.0 1.8 2 1 0 2 2 2 0 Ran-interacting Mog1 protein Csm1_N PF18504.1 EKE38367.1 - 5.4 7.4 11.8 7 7.1 5.2 2.7 2 0 0 2 2 2 0 Csm1 N-terminal domain Vps35 PF03635.17 EKE38368.1 - 9.6e-129 431.0 35.0 1.1e-128 430.8 35.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Hydrolase_6 PF13344.6 EKE38369.1 - 5.8e-19 68.1 0.0 1e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EKE38369.1 - 1.5e-09 37.7 0.0 3.8e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like HGTP_anticodon PF03129.20 EKE38370.1 - 2e-15 56.7 0.0 7.1e-15 54.9 0.0 2.0 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EKE38370.1 - 1.3e-11 44.8 0.0 7.8e-11 42.3 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Arf PF00025.21 EKE38372.1 - 1.1e-41 142.1 0.0 1.3e-41 141.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EKE38372.1 - 1.7e-11 44.0 0.0 2e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38372.1 - 2.1e-09 37.7 0.0 3.7e-09 36.8 0.0 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EKE38372.1 - 1.2e-07 31.2 1.2 2.3e-05 23.7 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EKE38372.1 - 0.0013 18.2 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE38372.1 - 0.002 18.0 0.0 0.56 10.1 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EKE38372.1 - 0.004 16.7 0.0 0.062 12.8 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EKE38372.1 - 0.025 14.9 0.0 0.048 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EKE38372.1 - 0.03 14.4 0.0 0.043 13.9 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE38372.1 - 0.033 13.5 0.0 0.048 13.0 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DLIC PF05783.11 EKE38372.1 - 0.053 12.3 0.1 0.078 11.8 0.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) ODC_AZ PF02100.17 EKE38372.1 - 0.091 12.7 0.0 0.42 10.6 0.0 1.9 1 1 1 2 2 2 0 Ornithine decarboxylase antizyme AAA_16 PF13191.6 EKE38372.1 - 0.16 12.3 0.0 4 7.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Ank_2 PF12796.7 EKE38373.1 - 2.6e-31 108.0 5.5 5.8e-09 36.4 0.4 4.9 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EKE38373.1 - 2.1e-29 101.2 3.4 5.1e-06 26.7 0.0 7.5 5 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EKE38373.1 - 2.9e-22 78.7 7.6 1.7e-07 31.7 0.1 6.7 3 3 5 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE38373.1 - 5.4e-21 72.4 8.6 0.0058 17.0 0.0 8.8 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EKE38373.1 - 3.5e-20 71.5 6.0 0.11 13.0 0.0 8.8 8 0 0 8 8 8 6 Ankyrin repeat Stirrup PF09061.6 EKE38373.1 - 0.034 14.4 0.1 8.4 6.7 0.0 2.8 2 0 0 2 2 2 0 Stirrup GED PF02212.18 EKE38373.1 - 0.069 13.3 5.5 1.7 8.9 0.2 3.9 3 0 0 3 3 3 0 Dynamin GTPase effector domain Stealth_CR4 PF17103.5 EKE38374.1 - 0.029 14.2 0.1 0.073 13.0 0.1 1.7 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 DASH_Dad3 PF08656.10 EKE38374.1 - 1.4 9.0 7.6 2.7 8.2 0.1 4.2 4 0 0 4 4 4 0 DASH complex subunit Dad3 PLDc PF00614.22 EKE38375.1 - 2.6e-19 68.5 1.8 5.8e-09 35.8 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EKE38375.1 - 8.5e-18 64.5 3.7 1.5e-10 41.1 0.7 3.0 2 1 0 2 2 2 2 PLD-like domain DUF4162 PF13732.6 EKE38376.1 - 0.0095 16.6 0.1 0.022 15.4 0.1 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4162) Phage_HK97_TLTM PF06120.11 EKE38376.1 - 0.052 12.7 2.0 0.22 10.7 2.1 1.7 1 1 1 2 2 2 0 Tail length tape measure protein DUF1359 PF07097.11 EKE38376.1 - 0.29 11.4 4.9 3.2 8.0 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1359) Ribosomal_L30 PF00327.20 EKE38377.1 - 5.5e-20 71.0 1.9 1.6e-19 69.5 1.9 1.9 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 EKE38377.1 - 0.015 15.5 1.6 0.037 14.3 1.6 1.7 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain Med7 PF05983.11 EKE38378.1 - 4.8e-21 75.7 4.5 1.5e-20 74.1 4.5 1.7 1 1 0 1 1 1 1 MED7 protein Sec66 PF09802.9 EKE38378.1 - 0.063 12.9 1.1 0.14 11.8 1.1 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 DUF4337 PF14235.6 EKE38378.1 - 0.14 12.3 2.5 0.15 12.2 2.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) RabGAP-TBC PF00566.18 EKE38379.1 - 9.4e-19 67.9 13.1 9.4e-19 67.9 13.1 3.0 2 1 0 2 2 2 1 Rab-GTPase-TBC domain DAPDH_C PF16654.5 EKE38379.1 - 4.3 7.2 5.8 2.9 7.7 1.2 2.4 2 0 0 2 2 2 0 Diaminopimelic acid dehydrogenase C-terminal domain Prefoldin PF02996.17 EKE38380.1 - 0.086 12.8 0.4 0.2 11.6 0.4 1.6 1 0 0 1 1 1 0 Prefoldin subunit YabA PF06156.13 EKE38380.1 - 1.4 9.6 4.6 2.1 9.0 1.1 2.6 1 1 0 2 2 2 0 Initiation control protein YabA Shugoshin_N PF07558.11 EKE38380.1 - 1.7 8.6 7.6 6.3 6.8 0.7 3.0 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region RIO1 PF01163.22 EKE38381.1 - 6.1e-47 159.7 0.0 9.8e-47 159.0 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 EKE38381.1 - 5.8e-33 113.0 0.5 1.8e-32 111.4 0.4 1.8 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 EKE38381.1 - 1.9e-08 34.5 0.6 0.0074 16.2 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EKE38381.1 - 0.0013 18.1 0.3 0.091 12.1 0.0 2.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EKE38381.1 - 0.019 14.5 0.1 0.061 12.9 0.1 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase Pkinase PF00069.25 EKE38381.1 - 0.11 11.8 1.0 0.73 9.1 1.0 2.2 1 1 0 1 1 1 0 Protein kinase domain Ribosomal_L40e PF01020.17 EKE38382.1 - 1.2e-29 102.0 8.0 1.3e-29 101.8 8.0 1.0 1 0 0 1 1 1 1 Ribosomal L40e family Ras PF00071.22 EKE38386.1 - 3.1e-48 163.4 0.5 3.7e-48 163.2 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38386.1 - 5.2e-36 123.5 0.3 1e-35 122.5 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38386.1 - 1.3e-15 57.2 0.1 1.8e-15 56.8 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE38386.1 - 3e-09 36.6 0.4 3.7e-09 36.3 0.4 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE38386.1 - 2.7e-06 27.4 0.1 7.6e-06 26.0 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE38386.1 - 5.5e-05 22.8 0.2 0.00021 20.9 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA PF00004.29 EKE38386.1 - 0.0052 17.2 0.8 0.29 11.6 0.8 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EKE38386.1 - 0.011 15.6 1.0 1.5 8.7 0.1 2.3 1 1 1 2 2 2 0 RsgA GTPase SRPRB PF09439.10 EKE38386.1 - 0.039 13.4 0.0 0.062 12.7 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 EKE38386.1 - 0.056 13.2 0.2 0.089 12.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKE38386.1 - 0.06 12.9 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EKE38386.1 - 0.065 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 EKE38386.1 - 0.07 12.9 0.3 0.44 10.3 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF1615 PF07759.12 EKE38386.1 - 0.081 12.1 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1615) G-alpha PF00503.20 EKE38386.1 - 0.1 11.7 4.1 5.1 6.2 0.2 2.8 1 1 2 3 3 3 0 G-protein alpha subunit DUF848 PF05852.11 EKE38386.1 - 0.15 12.2 0.7 0.64 10.1 0.4 1.9 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) AAA_33 PF13671.6 EKE38386.1 - 0.16 12.1 0.1 0.32 11.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain DUF900 PF05990.12 EKE38387.1 - 1.8e-24 86.5 0.0 2.9e-24 85.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_1 PF00561.20 EKE38387.1 - 0.023 14.3 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKE38387.1 - 0.074 13.7 0.0 0.11 13.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family UbiA PF01040.18 EKE38387.1 - 2.5 7.3 9.8 0.31 10.3 5.3 1.7 1 1 0 1 1 1 0 UbiA prenyltransferase family FHA PF00498.26 EKE38388.1 - 0.00013 22.2 0.1 0.00031 21.0 0.1 1.7 1 0 0 1 1 1 1 FHA domain Thioredoxin PF00085.20 EKE38389.1 - 2.8e-26 91.5 0.1 3.2e-26 91.3 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 EKE38389.1 - 5.2e-05 23.4 0.0 7.5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EKE38389.1 - 0.00024 21.5 0.2 0.0011 19.4 0.2 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_6 PF13848.6 EKE38389.1 - 0.0005 20.0 0.1 0.006 16.5 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EKE38389.1 - 0.0019 18.5 0.0 0.015 15.6 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 EKE38389.1 - 0.029 13.7 0.0 0.046 13.1 0.0 1.4 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family DUF1431 PF07248.12 EKE38389.1 - 0.12 12.6 0.1 0.17 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1431) PRA1 PF03208.19 EKE38390.1 - 0.00041 20.0 9.1 0.00061 19.4 9.1 1.2 1 0 0 1 1 1 1 PRA1 family protein FtsX PF02687.21 EKE38390.1 - 3.7 8.1 14.6 7.1 7.2 14.6 1.6 1 1 0 1 1 1 0 FtsX-like permease family DUF2207 PF09972.9 EKE38390.1 - 5.8 5.6 10.9 9.7 4.8 10.9 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DHHC PF01529.20 EKE38391.1 - 2.1e-26 92.6 16.0 2.1e-26 92.6 16.0 2.9 2 1 0 2 2 2 2 DHHC palmitoyltransferase CCB1 PF12046.8 EKE38392.1 - 0.052 12.9 0.1 0.097 12.0 0.1 1.4 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B ER_lumen_recept PF00810.18 EKE38394.1 - 5e-51 173.4 15.9 9.9e-51 172.4 15.9 1.5 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EKE38394.1 - 0.0012 18.5 17.6 0.0035 17.1 1.0 4.2 3 2 1 4 4 4 3 PQ loop repeat Chitin_synth_2 PF03142.15 EKE38395.1 - 5.7e-33 114.3 0.7 5.7e-33 114.3 0.7 2.8 2 1 1 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EKE38395.1 - 1e-12 48.4 11.7 8.7e-12 45.4 11.7 2.3 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EKE38395.1 - 8.7e-09 35.6 0.0 1.4e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 UCH PF00443.29 EKE38396.1 - 1.1e-39 136.5 1.2 3.3e-39 135.0 1.2 1.9 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE38396.1 - 1.1e-08 35.1 16.0 1.7e-08 34.4 0.5 3.6 2 1 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase GCP_N_terminal PF17681.1 EKE38397.1 - 4.3e-30 105.4 3.7 8.1e-30 104.5 3.7 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EKE38397.1 - 2.9e-18 66.4 4.7 2.9e-18 66.4 4.7 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal Get5_bdg PF16843.5 EKE38397.1 - 0.039 13.4 0.2 3.1 7.4 0.1 2.7 2 0 0 2 2 2 0 Binding domain to Get4 on Get5, Golgi to ER traffic protein Beach PF02138.18 EKE38398.1 - 6.1e-23 81.6 20.1 1.3e-21 77.2 20.1 3.1 1 1 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EKE38398.1 - 0.00044 20.3 0.5 0.0015 18.6 0.5 2.0 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH LRR_4 PF12799.7 EKE38399.1 - 1.1e-13 51.1 58.8 0.00038 20.8 1.1 8.1 4 1 5 9 9 9 7 Leucine Rich repeats (2 copies) DSPc PF00782.20 EKE38399.1 - 1.2e-13 51.0 0.0 2.3e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 EKE38399.1 - 4.9e-07 29.4 42.3 0.00026 20.7 2.6 7.2 2 2 7 9 9 9 7 Leucine rich repeat Init_tRNA_PT PF04179.12 EKE38399.1 - 0.019 15.3 0.0 0.035 14.4 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain LRR_1 PF00560.33 EKE38399.1 - 0.06 13.9 48.4 2.2 9.2 0.7 11.5 7 2 2 9 9 9 0 Leucine Rich Repeat LRR_6 PF13516.6 EKE38399.1 - 0.064 13.3 49.3 0.13 12.4 0.1 10.7 9 2 2 11 11 11 0 Leucine Rich repeat NOT2_3_5 PF04153.18 EKE38400.1 - 9.4e-12 45.1 0.3 9.4e-12 45.1 0.3 1.7 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Pkinase PF00069.25 EKE38401.1 - 2.3e-20 73.1 0.0 4.8e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 EKE38401.1 - 4.4e-10 40.0 15.6 0.00081 20.2 0.4 6.4 7 0 0 7 7 7 3 WD domain, G-beta repeat Pkinase_Tyr PF07714.17 EKE38401.1 - 4e-09 36.1 0.0 8e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE38401.1 - 0.0018 17.7 0.0 0.0032 16.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Hira PF07569.11 EKE38401.1 - 0.004 16.9 0.1 0.47 10.1 0.0 3.2 2 1 1 3 3 3 1 TUP1-like enhancer of split GRAM PF02893.20 EKE38402.1 - 7e-06 25.9 0.8 2.3e-05 24.2 0.5 2.1 2 0 0 2 2 2 1 GRAM domain MCPsignal PF00015.21 EKE38402.1 - 2.1 8.1 6.6 3.7 7.3 0.4 2.6 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Hydrolase_4 PF12146.8 EKE38403.1 - 6.1e-44 150.1 0.0 7.3e-44 149.8 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EKE38403.1 - 5.1e-16 59.1 0.0 2.4e-12 47.1 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKE38403.1 - 1.7e-12 48.4 0.0 2.4e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EKE38403.1 - 3.2e-06 26.8 0.2 0.0093 15.5 0.0 2.3 2 1 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_5 PF12695.7 EKE38403.1 - 0.00011 22.0 0.1 0.66 9.7 0.0 3.0 3 0 0 3 3 3 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EKE38403.1 - 0.00046 20.1 0.0 3.5 7.4 0.0 3.1 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase BAAT_C PF08840.11 EKE38403.1 - 0.00064 19.7 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EKE38403.1 - 0.00087 18.9 0.0 0.33 10.5 0.0 2.3 2 1 0 2 2 2 2 Dienelactone hydrolase family ABC2_membrane_3 PF12698.7 EKE38403.1 - 0.0068 15.6 0.8 0.0095 15.1 0.8 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein FSH1 PF03959.13 EKE38403.1 - 0.015 14.9 0.0 0.15 11.7 0.0 2.4 2 1 0 2 2 2 0 Serine hydrolase (FSH1) DUF4318 PF14201.6 EKE38403.1 - 0.048 14.1 0.0 0.2 12.2 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4318) Thioesterase PF00975.20 EKE38403.1 - 0.093 12.8 0.0 0.34 11.0 0.0 1.8 2 0 0 2 2 2 0 Thioesterase domain Hydantoinase_A PF01968.18 EKE38403.1 - 0.13 11.5 0.0 0.36 10.0 0.0 1.6 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase GTP_EFTU PF00009.27 EKE38405.1 - 5.1e-37 127.3 0.9 8.7e-37 126.5 0.9 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EKE38405.1 - 5.7e-06 26.6 0.0 1.9e-05 24.9 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EKE38405.1 - 0.00013 22.0 2.5 0.00099 19.2 0.6 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 EKE38405.1 - 0.001 18.7 0.2 0.0029 17.2 0.2 1.7 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EKE38405.1 - 0.0012 18.3 1.5 0.004 16.5 1.6 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region HBS1_N PF08938.10 EKE38405.1 - 0.0034 17.7 0.3 0.0084 16.4 0.3 1.6 1 0 0 1 1 1 1 HBS1 N-terminus SRPRB PF09439.10 EKE38405.1 - 0.0047 16.4 2.2 0.083 12.3 0.4 2.5 1 1 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU_D2 PF03144.25 EKE38405.1 - 0.0049 17.2 6.4 0.038 14.4 4.2 2.6 2 0 0 2 2 2 1 Elongation factor Tu domain 2 G-alpha PF00503.20 EKE38405.1 - 0.011 14.9 1.9 0.055 12.6 0.3 2.5 2 1 1 3 3 3 0 G-protein alpha subunit GTP_EFTU_D4 PF14578.6 EKE38405.1 - 0.073 13.0 3.1 0.22 11.4 3.1 1.8 1 0 0 1 1 1 0 Elongation factor Tu domain 4 AAA_33 PF13671.6 EKE38405.1 - 0.14 12.3 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EKE38405.1 - 0.56 9.7 5.4 0.15 11.6 0.4 2.5 3 1 0 3 3 3 0 Ferrous iron transport protein B Pkinase PF00069.25 EKE38408.1 - 3.5e-09 36.4 0.0 6.1e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EKE38408.1 - 2.1e-06 27.5 2.3 0.1 12.9 0.1 3.7 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 EKE38408.1 - 3.2e-05 24.0 0.4 0.37 10.8 0.0 2.9 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKE38408.1 - 8.1e-05 22.9 0.1 0.00025 21.4 0.1 1.9 1 1 0 1 1 1 1 HEAT repeats Cohesin_HEAT PF12765.7 EKE38408.1 - 0.0042 17.3 0.1 0.17 12.2 0.0 3.5 4 0 0 4 4 4 1 HEAT repeat associated with sister chromatid cohesion Adaptin_N PF01602.20 EKE38408.1 - 0.008 14.8 1.7 0.074 11.6 0.4 2.4 1 1 1 2 2 2 1 Adaptin N terminal region HEAT_EZ PF13513.6 EKE38408.1 - 0.059 13.9 0.2 10 6.8 0.0 2.7 2 0 0 2 2 2 0 HEAT-like repeat UPF0128 PF03673.13 EKE38408.1 - 0.075 12.5 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) Pkinase_Tyr PF07714.17 EKE38408.1 - 0.12 11.7 0.0 0.28 10.4 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase zf-MIZ PF02891.20 EKE38409.1 - 1.1e-16 60.3 0.2 1.8e-16 59.6 0.2 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EKE38409.1 - 1e-08 34.9 0.6 1e-08 34.9 0.6 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit PINIT PF14324.6 EKE38409.1 - 0.00038 20.8 2.2 0.00038 20.8 0.2 2.1 2 0 0 2 2 2 1 PINIT domain zf-C3HC4_2 PF13923.6 EKE38409.1 - 0.16 11.9 0.2 0.29 11.0 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) sCache_like PF16736.5 EKE38409.1 - 0.32 11.1 2.1 4.7 7.3 0.4 2.5 2 0 0 2 2 2 0 Single Cache-like Gemini_AL1 PF00799.20 EKE38410.1 - 0.002 18.5 0.5 0.012 15.9 0.1 2.4 2 0 0 2 2 2 1 Geminivirus Rep catalytic domain DUF2959 PF11172.8 EKE38410.1 - 0.011 15.9 3.3 0.011 15.9 3.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2959) dNK PF01712.19 EKE38412.1 - 4.9e-13 49.4 3.1 4.2e-09 36.6 0.0 2.1 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_18 PF13238.6 EKE38412.1 - 3.6e-09 37.3 0.0 1.7e-05 25.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 EKE38412.1 - 0.0012 18.0 0.0 0.0017 17.5 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 EKE38412.1 - 0.0066 16.9 0.0 0.01 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EKE38412.1 - 0.0089 16.3 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EKE38412.1 - 0.0098 15.6 0.1 0.018 14.7 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain NTPase_1 PF03266.15 EKE38412.1 - 0.023 14.6 0.1 0.052 13.5 0.1 1.6 1 1 0 1 1 1 0 NTPase AAA_17 PF13207.6 EKE38412.1 - 0.081 13.4 0.1 11 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF1981 PF09324.10 EKE38412.1 - 0.095 12.6 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1981) RsgA_GTPase PF03193.16 EKE38412.1 - 0.097 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 EKE38412.1 - 0.17 11.9 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EKE38412.1 - 0.18 11.5 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain HIN PF02760.15 EKE38414.1 - 0.017 14.8 0.2 0.025 14.3 0.2 1.3 1 0 0 1 1 1 0 HIN-200/IF120x domain Multi_ubiq PF14452.6 EKE38414.1 - 0.29 11.4 1.4 0.74 10.1 0.5 2.0 2 0 0 2 2 2 0 Multiubiquitin GDP_Man_Dehyd PF16363.5 EKE38415.1 - 1.4e-67 228.5 0.0 1.6e-67 228.2 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EKE38415.1 - 9.3e-58 195.5 0.0 1.2e-57 195.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EKE38415.1 - 1.4e-19 70.1 0.1 2.2e-18 66.3 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EKE38415.1 - 2.8e-19 69.4 0.4 4.8e-16 58.7 0.1 2.9 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EKE38415.1 - 2.8e-12 46.4 0.0 4.3e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EKE38415.1 - 6.9e-11 41.8 0.3 2.5e-10 39.9 0.3 1.9 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EKE38415.1 - 1.1e-07 32.0 0.0 3.3e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 EKE38415.1 - 3.5e-07 29.9 0.0 7.9e-07 28.7 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EKE38415.1 - 7.6e-05 22.7 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EKE38415.1 - 0.0023 17.5 0.6 1.3 8.6 0.0 2.4 2 1 0 2 2 2 2 NmrA-like family Glyco_trans_4_2 PF13477.6 EKE38415.1 - 0.039 14.0 0.3 0.1 12.6 0.2 1.7 2 0 0 2 2 2 0 Glycosyl transferase 4-like DUF2608 PF11019.8 EKE38415.1 - 0.048 13.1 0.9 0.091 12.2 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) DUF1132 PF06575.12 EKE38415.1 - 0.051 14.0 0.0 13 6.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1132) UDPG_MGDP_dh_N PF03721.14 EKE38415.1 - 0.055 13.0 0.2 0.14 11.7 0.1 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF445 PF04286.12 EKE38416.1 - 0.047 13.5 2.1 0.063 13.1 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) TRAPPC9-Trs120 PF08626.11 EKE38417.1 - 2.7e-12 45.0 10.0 1.3e-10 39.4 5.8 2.5 2 0 0 2 2 2 2 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit ANAPC5 PF12862.7 EKE38417.1 - 0.024 14.7 0.0 0.099 12.7 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 TPR_8 PF13181.6 EKE38417.1 - 0.69 10.3 5.7 7.8 7.0 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-C2H2_2 PF12756.7 EKE38419.1 - 0.043 14.1 0.1 0.15 12.4 0.1 1.9 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) GAGBD PF16828.5 EKE38420.1 - 0.04 14.0 0.1 0.067 13.3 0.1 1.3 1 0 0 1 1 1 0 GAG-binding domain on surface antigen FAE1_CUT1_RppA PF08392.12 EKE38421.1 - 1.5e-83 280.5 0.0 1.9e-83 280.1 0.0 1.1 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.10 EKE38421.1 - 8.5e-10 38.7 0.0 1.8e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Chal_sti_synt_C PF02797.15 EKE38421.1 - 9.8e-08 32.1 0.0 3.7e-07 30.2 0.0 2.0 3 0 0 3 3 3 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EKE38421.1 - 0.00098 18.6 0.0 0.0016 18.0 0.0 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III PF08545.10 EKE38421.1 - 0.0061 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Phage_holin_5_2 PF16079.5 EKE38421.1 - 0.02 15.2 0.3 0.058 13.7 0.1 1.8 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V Metallophos PF00149.28 EKE38422.1 - 2.1e-31 110.0 0.1 2.7e-31 109.7 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EKE38422.1 - 0.0014 19.0 1.2 0.012 16.1 0.7 2.2 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Rad52_Rad22 PF04098.15 EKE38424.1 - 7.6e-33 113.6 0.4 9.7e-33 113.3 0.4 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein DUF3400 PF11880.8 EKE38424.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) ESCRT-II PF05871.12 EKE38424.1 - 0.29 11.4 1.9 0.4 10.9 0.3 1.9 1 1 1 2 2 2 0 ESCRT-II complex subunit YL1 PF05764.13 EKE38425.1 - 6.5e-06 26.4 21.4 7.4e-06 26.2 21.4 1.2 1 0 0 1 1 1 1 YL1 nuclear protein LTV PF04180.14 EKE38425.1 - 0.024 14.4 18.3 0.024 14.4 18.3 1.1 1 0 0 1 1 1 0 Low temperature viability protein TGBp3 PF02495.17 EKE38425.1 - 0.11 12.2 0.3 0.17 11.6 0.3 1.3 1 0 0 1 1 1 0 Triple gene block 3 GAGA_bind PF06217.12 EKE38425.1 - 0.5 10.6 12.2 0.61 10.3 12.2 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family RRN3 PF05327.11 EKE38425.1 - 1.8 7.0 7.8 2 6.9 7.8 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 EKE38425.1 - 2.3 6.4 20.7 2.7 6.2 20.7 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 EKE38425.1 - 2.5 7.9 21.8 3.3 7.5 21.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 EKE38425.1 - 4.9 5.1 11.2 4.8 5.2 11.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TLD PF07534.16 EKE38426.1 - 2.4e-07 31.1 0.0 4.5e-07 30.2 0.0 1.7 1 1 0 1 1 1 1 TLD Fib_alpha PF08702.10 EKE38426.1 - 0.0024 18.1 2.3 0.0053 16.9 2.3 1.5 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family DUF3583 PF12126.8 EKE38426.1 - 0.031 13.7 5.6 0.036 13.5 3.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3583) DUF4600 PF15372.6 EKE38426.1 - 0.5 10.8 5.2 0.88 10.0 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) OmpH PF03938.14 EKE38426.1 - 4.4 7.6 7.6 7.1 7.0 7.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SlyX PF04102.12 EKE38426.1 - 7.5 7.3 7.6 6.1 7.5 0.4 2.4 1 1 0 2 2 2 0 SlyX JAB PF01398.21 EKE38428.1 - 1.4e-05 25.0 0.0 2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UPF0172 PF03665.13 EKE38428.1 - 0.039 14.0 0.0 0.043 13.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) Astro_capsid_p2 PF16580.5 EKE38428.1 - 0.14 11.6 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 C-terminal tail of astrovirus capsid projection or spike SabA_adhesion PF18304.1 EKE38429.1 - 0.17 11.1 0.9 2.6 7.2 0.1 2.2 2 0 0 2 2 2 0 SabA N-terminal extracellular adhesion domain Clathrin_H_link PF13838.6 EKE38430.1 - 0.021 14.7 0.3 0.12 12.3 0.3 1.9 1 1 0 1 1 1 0 Clathrin-H-link Collectrin PF16959.5 EKE38430.1 - 0.042 13.6 0.2 0.045 13.5 0.2 1.0 1 0 0 1 1 1 0 Renal amino acid transporter PolyA_pol_RNAbd PF12627.7 EKE38430.1 - 0.076 12.8 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A FliS PF02561.14 EKE38430.1 - 0.077 13.3 0.2 0.081 13.2 0.2 1.1 1 0 0 1 1 1 0 Flagellar protein FliS Peptidase_M3 PF01432.20 EKE38431.1 - 1.5e-121 406.9 8.1 1.5e-121 406.9 8.1 1.6 2 0 0 2 2 2 1 Peptidase family M3 HDV_ag PF01517.18 EKE38431.1 - 0.22 11.3 0.4 0.58 9.9 0.4 1.7 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen Peptidase_M48_N PF16491.5 EKE38431.1 - 2.5 8.0 5.8 0.83 9.5 1.0 2.5 2 1 0 2 2 2 0 CAAX prenyl protease N-terminal, five membrane helices Ras PF00071.22 EKE38433.1 - 3.8e-43 146.9 0.7 4.8e-43 146.6 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38433.1 - 1.5e-28 99.4 0.2 2.8e-28 98.5 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38433.1 - 3.3e-15 56.0 0.4 4.4e-15 55.6 0.4 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE38433.1 - 4.5e-07 29.5 0.4 1e-06 28.3 0.2 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE38433.1 - 1.8e-06 27.7 1.7 0.00022 20.8 1.7 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE38433.1 - 5.3e-05 22.7 0.2 7.9e-05 22.1 0.2 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE38433.1 - 5.6e-05 23.2 1.2 0.00014 21.9 0.3 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EKE38433.1 - 0.0029 17.9 0.5 0.31 11.3 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 EKE38433.1 - 0.0029 17.4 0.6 0.64 9.7 0.0 2.2 1 1 1 2 2 2 2 AAA domain AAA_7 PF12775.7 EKE38433.1 - 0.004 16.7 0.7 0.0077 15.8 0.2 1.7 2 0 0 2 2 2 1 P-loop containing dynein motor region PduV-EutP PF10662.9 EKE38433.1 - 0.0084 15.9 1.1 0.039 13.7 0.1 2.4 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EKE38433.1 - 0.012 15.5 0.2 0.79 9.6 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase CENP-M PF11111.8 EKE38433.1 - 0.017 14.4 0.1 0.033 13.4 0.1 1.5 1 0 0 1 1 1 0 Centromere protein M (CENP-M) Septin PF00735.18 EKE38433.1 - 0.017 14.4 0.1 0.017 14.4 0.1 1.8 2 1 0 2 2 2 0 Septin Dzip-like_N PF13815.6 EKE38433.1 - 0.044 13.8 1.1 0.07 13.1 1.1 1.3 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal TsaE PF02367.17 EKE38433.1 - 0.057 13.4 0.2 0.18 11.8 0.1 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 EKE38433.1 - 0.069 13.5 0.0 0.13 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EKE38433.1 - 0.14 12.7 1.5 0.47 11.0 0.2 2.3 2 1 0 2 2 2 0 AAA domain ubiquitin PF00240.23 EKE38434.1 - 8e-11 41.5 3.8 9.8e-06 25.2 0.1 2.8 3 0 0 3 3 3 2 Ubiquitin family Rad60-SLD PF11976.8 EKE38434.1 - 2.6e-07 30.3 4.1 0.00015 21.5 0.7 2.6 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Arc_C PF18162.1 EKE38434.1 - 0.0078 16.0 0.1 0.019 14.8 0.1 1.6 1 0 0 1 1 1 1 Arc C-lobe Ubiquitin_5 PF18037.1 EKE38434.1 - 0.027 14.8 0.8 0.65 10.4 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain DUF1801 PF08818.11 EKE38434.1 - 0.18 12.3 4.3 37 4.9 0.2 3.7 1 1 0 2 2 2 0 Domain of unknown function (DU1801) Cation_ATPase_C PF00689.21 EKE38435.1 - 2.8e-40 138.0 4.5 2.8e-40 138.0 4.5 3.0 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EKE38435.1 - 1.3e-39 135.6 5.2 2.5e-38 131.4 2.2 3.5 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EKE38435.1 - 3.7e-22 79.6 0.0 1.3e-21 77.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EKE38435.1 - 1.2e-12 47.8 0.0 3.1e-12 46.4 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EKE38435.1 - 1.1e-09 37.9 0.1 2e-09 37.0 0.1 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EKE38435.1 - 3.7e-06 26.9 0.3 3.7e-06 26.9 0.3 4.0 5 0 0 5 5 5 1 haloacid dehalogenase-like hydrolase DUF4271 PF14093.6 EKE38435.1 - 0.36 10.7 0.0 0.36 10.7 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4271) PP2C PF00481.21 EKE38437.1 - 7.2e-55 186.4 0.0 1e-54 185.9 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE38437.1 - 9.4e-07 28.7 0.0 1.7e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C G-alpha PF00503.20 EKE38437.1 - 0.00043 19.6 5.3 0.0011 18.2 2.0 2.4 2 1 0 2 2 2 1 G-protein alpha subunit adh_short_C2 PF13561.6 EKE38438.1 - 1.3e-51 175.5 0.0 3.6e-50 170.7 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EKE38438.1 - 9.4e-47 159.0 0.0 1.2e-46 158.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EKE38438.1 - 1.4e-12 47.9 0.0 1.8e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EKE38438.1 - 3.1e-06 26.8 0.2 6.1e-06 25.9 0.2 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EKE38438.1 - 0.00015 21.2 0.1 0.0021 17.5 0.1 2.0 1 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EKE38438.1 - 0.00046 19.4 0.1 0.00074 18.7 0.1 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein PCMT PF01135.19 EKE38438.1 - 0.061 13.1 0.1 0.14 11.9 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RmlD_sub_bind PF04321.17 EKE38438.1 - 0.061 12.4 0.0 0.093 11.8 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Peptidase_M20 PF01546.28 EKE38439.1 - 5e-10 39.4 0.0 1.3e-08 34.8 0.0 2.5 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EKE38439.1 - 0.00063 18.8 0.0 0.0011 18.0 0.0 1.4 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase DUF1682 PF07946.14 EKE38440.1 - 5.1e-54 183.7 9.1 6.2e-54 183.4 9.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF1664 PF07889.12 EKE38441.1 - 1.1 9.3 4.3 2.1 8.4 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Ssu72 PF04722.13 EKE38441.1 - 1.2 8.7 6.0 1.4 8.4 4.3 1.8 1 1 1 2 2 2 0 Ssu72-like protein CENP-F_leu_zip PF10473.9 EKE38441.1 - 2.8 8.0 14.6 5.9 6.9 14.6 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Rsa3 PF14615.6 EKE38442.1 - 0.016 14.7 0.1 0.062 12.9 0.1 2.0 1 0 0 1 1 1 0 Ribosome-assembly protein 3 DUF2070 PF09843.9 EKE38442.1 - 4.1 5.6 13.6 0.22 9.8 2.1 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) tRNA-synt_1 PF00133.22 EKE38443.1 - 1.5e-45 155.6 0.8 1.5e-30 106.1 0.0 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EKE38443.1 - 1.1e-22 80.3 0.1 5e-10 38.7 0.0 3.1 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EKE38443.1 - 1.2e-11 44.8 0.4 2.8e-11 43.6 0.4 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EKE38443.1 - 2.2e-06 27.2 0.0 8.7e-06 25.3 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain pXO2-72 PF17443.2 EKE38443.1 - 0.043 14.1 0.7 0.81 10.0 0.1 2.7 2 0 0 2 2 2 0 Uncharacterized protein pXO2-72 PRKCSH_1 PF13015.6 EKE38444.1 - 0.00015 21.5 0.9 0.00023 20.9 0.9 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 EKE38444.1 - 0.00073 19.5 1.5 0.0012 18.7 1.5 1.5 1 1 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EKE38444.1 - 0.0049 16.0 1.4 0.0075 15.4 1.4 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor BET PF17035.5 EKE38445.1 - 0.035 14.3 2.4 0.093 12.9 2.4 1.7 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation Cation_efflux PF01545.21 EKE38446.1 - 1e-55 188.6 6.8 1.4e-55 188.1 6.8 1.2 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.22 EKE38446.1 - 6.9e-05 22.2 11.3 6.9e-05 22.2 11.3 1.6 1 1 0 1 1 1 1 ZIP Zinc transporter TctB PF07331.11 EKE38446.1 - 0.003 17.9 0.0 0.11 12.8 0.0 2.6 1 1 1 2 2 2 1 Tripartite tricarboxylate transporter TctB family V_ATPase_I PF01496.19 EKE38446.1 - 0.0077 14.2 1.0 0.011 13.7 1.0 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1980 PF09323.10 EKE38446.1 - 0.05 13.5 1.5 0.17 11.8 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Jiraiya PF15038.6 EKE38446.1 - 0.35 10.3 6.4 0.088 12.2 2.1 2.1 2 0 0 2 2 2 0 Jiraiya MgtE PF01769.16 EKE38446.1 - 1.2 9.5 12.6 2.5 8.5 3.3 3.1 2 1 1 3 3 3 0 Divalent cation transporter MCM PF00493.23 EKE38447.1 - 1.5e-99 331.7 2.2 3.1e-99 330.6 0.3 2.0 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EKE38447.1 - 4.2e-30 104.2 2.8 8.6e-30 103.2 2.8 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EKE38447.1 - 1.9e-29 101.9 0.2 4.4e-29 100.7 0.2 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EKE38447.1 - 6.5e-13 49.2 0.4 1.7e-12 47.9 0.4 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EKE38447.1 - 5.2e-06 26.0 0.1 0.00096 18.6 0.0 2.7 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EKE38447.1 - 9e-05 22.5 0.0 0.0002 21.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EKE38447.1 - 0.0025 17.7 0.1 0.02 14.8 0.0 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Phage_int_SAM_5 PF13102.6 EKE38447.1 - 0.023 15.0 0.4 0.074 13.4 0.4 1.8 1 0 0 1 1 1 0 Phage integrase SAM-like domain Metallophos PF00149.28 EKE38448.1 - 3.5e-27 96.2 0.1 7.8e-27 95.1 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF755 PF05501.11 EKE38448.1 - 0.068 13.5 2.0 0.12 12.7 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Sld5 PF05916.11 EKE38449.1 - 2.2e-06 28.1 0.0 4.4e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 GINS complex protein TBCC_N PF16752.5 EKE38449.1 - 0.075 13.5 2.2 1 9.8 0.3 2.2 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain DUF948 PF06103.11 EKE38449.1 - 0.18 12.1 0.3 0.18 12.1 0.3 2.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) C2 PF00168.30 EKE38450.1 - 2.3e-15 56.7 0.2 2.3e-15 56.7 0.2 2.1 1 1 1 2 2 2 1 C2 domain TLD PF07534.16 EKE38450.1 - 3.9e-05 23.9 0.1 8.2e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 TLD NIF PF03031.18 EKE38454.1 - 5.9e-35 120.3 0.7 8.3e-35 119.9 0.7 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.6 EKE38454.1 - 0.00051 20.2 2.9 0.28 11.2 0.1 2.7 1 1 2 3 3 3 2 Haloacid dehalogenase-like hydrolase Yippee-Mis18 PF03226.14 EKE38454.1 - 0.012 15.8 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Hydrolase PF00702.26 EKE38454.1 - 0.02 15.2 0.2 4.1 7.6 0.2 2.3 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Sorb PF02208.16 EKE38454.1 - 0.068 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Sorbin homologous domain PNK3P PF08645.11 EKE38454.1 - 0.072 12.8 0.9 0.36 10.5 0.1 2.3 1 1 0 2 2 2 0 Polynucleotide kinase 3 phosphatase Peptidase_C97 PF05903.14 EKE38454.1 - 0.23 11.3 1.4 0.71 9.7 0.7 1.9 1 1 1 2 2 2 0 PPPDE putative peptidase domain RabGAP-TBC PF00566.18 EKE38455.1 - 1.1e-33 116.8 11.5 2.4e-33 115.6 11.5 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PIG-S PF10510.9 EKE38455.1 - 0.13 11.0 3.5 0.22 10.3 3.5 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein PrpR_N PF06506.11 EKE38455.1 - 0.16 11.5 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 Propionate catabolism activator WD40 PF00400.32 EKE38456.1 - 4.1e-15 55.9 17.0 5.2e-05 23.9 0.1 5.7 6 1 0 6 6 6 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 EKE38456.1 - 2.2e-10 40.6 0.3 1.2e-09 38.3 0.0 2.4 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 EKE38456.1 - 0.0006 20.1 0.9 0.012 15.9 0.3 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Spem1 PF15670.5 EKE38456.1 - 0.34 10.5 1.4 26 4.3 0.0 2.3 2 0 0 2 2 2 0 Spermatid maturation protein 1 Ras PF00071.22 EKE38457.1 - 6.1e-53 178.7 0.4 7e-53 178.6 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38457.1 - 2.9e-25 88.8 0.0 4.7e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38457.1 - 9.4e-14 51.2 0.1 1.1e-13 51.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE38457.1 - 1.4e-05 24.6 0.1 1.7e-05 24.3 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE38457.1 - 0.0005 19.7 0.7 0.0011 18.5 0.2 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Proteasome PF00227.26 EKE38458.1 - 2.7e-59 199.9 0.0 8.9e-59 198.2 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 EKE38458.1 - 1.6e-10 40.5 0.3 2.6e-09 36.6 0.0 2.3 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature PQ-loop PF04193.14 EKE38459.1 - 8.4e-16 57.5 14.0 1.5e-10 40.6 3.1 3.4 4 0 0 4 4 4 2 PQ loop repeat ER_lumen_recept PF00810.18 EKE38459.1 - 5.9e-05 23.9 1.0 5.9e-05 23.9 1.0 3.2 2 1 1 3 3 3 1 ER lumen protein retaining receptor NDUF_B12 PF08122.12 EKE38460.1 - 0.023 14.8 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B12 subunit family Peptidase_C101 PF16218.5 EKE38460.1 - 0.038 13.2 1.9 0.043 13.1 1.9 1.1 1 0 0 1 1 1 0 Peptidase family C101 CC190 PF15768.5 EKE38460.1 - 0.12 12.4 7.1 0.13 12.3 7.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 190 DUF2790 PF10976.8 EKE38460.1 - 0.13 12.3 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2790) ASFV_J13L PF05568.11 EKE38461.1 - 0.15 11.8 0.6 0.2 11.4 0.6 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein Phage_holin_5_2 PF16079.5 EKE38461.1 - 0.33 11.3 6.1 2 8.8 1.3 2.2 1 1 1 2 2 2 0 Phage holin family Hol44, in holin superfamily V TEX12 PF15219.6 EKE38462.1 - 0.01 16.2 0.6 0.4 11.0 0.1 3.3 3 0 0 3 3 3 0 Testis-expressed 12 C1_2 PF03107.16 EKE38462.1 - 0.48 10.8 17.6 0.13 12.6 13.3 2.5 2 0 0 2 2 2 0 C1 domain C1_1 PF00130.22 EKE38462.1 - 0.63 10.0 18.8 0.24 11.3 14.8 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HECT PF00632.25 EKE38463.1 - 4.2e-92 308.9 1.1 6.4e-92 308.3 1.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EKE38463.1 - 0.00056 20.1 0.1 0.0019 18.4 0.1 1.8 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A ASFV_L11L PF05293.11 EKE38463.1 - 0.11 12.9 1.6 0.28 11.5 0.4 2.3 2 0 0 2 2 2 0 African swine fever virus (ASFV) L11L protein Atg14 PF10186.9 EKE38464.1 - 1.5e-06 27.5 10.1 1.5e-06 27.5 10.1 2.0 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1366 PF07104.11 EKE38464.1 - 0.019 14.7 0.2 0.019 14.7 0.2 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1366) ZapB PF06005.12 EKE38464.1 - 0.02 15.3 4.8 0.02 15.3 4.8 3.4 3 2 0 3 3 3 0 Cell division protein ZapB Cob_adeno_trans PF01923.18 EKE38464.1 - 0.1 12.7 9.8 2.2 8.4 0.2 2.6 1 1 1 2 2 2 0 Cobalamin adenosyltransferase CENP-H PF05837.12 EKE38464.1 - 0.49 10.8 24.3 2.3 8.7 0.7 3.1 1 1 2 3 3 3 0 Centromere protein H (CENP-H) KASH_CCD PF14662.6 EKE38464.1 - 2 8.2 26.3 7.2 6.4 10.3 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Speriolin_N PF15058.6 EKE38464.1 - 2.5 8.2 3.8 5.5 7.0 3.5 1.6 1 1 0 1 1 1 0 Speriolin N terminus Mto2_bdg PF12808.7 EKE38464.1 - 3.9 7.8 9.4 5.7 7.3 1.7 3.2 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Adhesin_P1_N PF18652.1 EKE38464.1 - 4.8 7.3 8.0 1.8 8.6 2.1 2.7 2 0 0 2 2 2 0 Adhesin P1 N-terminal domain PIG-L PF02585.17 EKE38465.1 - 3.1e-20 73.1 0.0 6.6e-20 72.1 0.0 1.6 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Glucosamine_iso PF01182.20 EKE38465.1 - 3.8e-17 62.9 0.0 8.5e-17 61.8 0.0 1.5 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase LEM PF03020.15 EKE38465.1 - 0.077 12.6 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 LEM domain PHD PF00628.29 EKE38466.1 - 0.042 13.7 1.7 0.042 13.7 1.7 2.1 2 0 0 2 2 2 0 PHD-finger PHD_4 PF16866.5 EKE38466.1 - 0.16 12.1 5.3 0.047 13.8 2.0 1.9 2 0 0 2 2 2 0 PHD-finger Sybindin PF04099.12 EKE38467.1 - 4.2e-18 65.6 1.6 4.8e-18 65.5 1.6 1.0 1 0 0 1 1 1 1 Sybindin-like family ABC_tran PF00005.27 EKE38468.1 - 6.4e-27 94.7 0.0 1.4e-26 93.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EKE38468.1 - 1.5e-14 53.9 25.5 6.3e-14 51.8 25.5 1.8 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 EKE38468.1 - 2.1e-11 44.2 0.3 1.6e-08 34.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EKE38468.1 - 0.014 14.8 0.0 0.15 11.4 0.0 2.0 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EKE38468.1 - 0.059 13.1 4.4 1 9.0 0.0 2.8 3 1 0 3 3 3 0 AAA ATPase domain AAA_30 PF13604.6 EKE38468.1 - 0.077 12.7 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EKE38468.1 - 1 9.8 6.1 0.22 12.0 0.9 2.2 2 0 0 2 2 2 0 AAA domain Mem_trans PF03547.18 EKE38468.1 - 5.4 5.3 7.1 10 4.4 7.1 1.4 1 0 0 1 1 1 0 Membrane transport protein BPL_N PF09825.9 EKE38469.1 - 0.1 11.7 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Ribosomal_L7Ae PF01248.26 EKE38470.1 - 6.1e-28 96.4 0.3 8.1e-28 96.0 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EKE38470.1 - 7e-05 22.6 0.0 9.4e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 EKE38470.1 - 8e-05 22.7 0.0 9.7e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 TFIIS_C PF01096.18 EKE38471.1 - 3.5e-21 74.8 13.4 1.1e-20 73.2 2.3 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EKE38471.1 - 4.1e-07 29.8 3.6 4.1e-07 29.8 3.6 2.8 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 EKE38471.1 - 4.7e-06 26.5 4.0 0.0011 18.8 0.2 2.2 2 0 0 2 2 2 2 Transposase zinc-ribbon domain zf-DNA_Pol PF08996.10 EKE38471.1 - 0.004 16.9 4.5 0.012 15.4 0.8 2.1 1 1 1 2 2 2 1 DNA Polymerase alpha zinc finger zinc_ribbon_10 PF10058.9 EKE38471.1 - 0.0046 16.6 11.9 0.0076 16.0 0.6 3.2 2 2 1 3 3 3 1 Predicted integral membrane zinc-ribbon metal-binding protein Zn_ribbon_recom PF13408.6 EKE38471.1 - 0.0091 16.5 4.1 0.064 13.8 0.1 2.3 2 1 0 2 2 2 1 Recombinase zinc beta ribbon domain DNA_RNApol_7kD PF03604.13 EKE38471.1 - 0.019 14.7 8.1 1 9.1 0.0 3.5 3 1 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-CHY PF05495.12 EKE38471.1 - 0.022 15.2 2.2 0.022 15.2 2.2 2.2 1 1 1 2 2 2 0 CHY zinc finger zf-GRF PF06839.12 EKE38471.1 - 0.029 14.5 0.8 0.029 14.5 0.8 2.7 2 1 0 2 2 2 0 GRF zinc finger zf-C2HC5 PF06221.13 EKE38471.1 - 0.043 13.8 1.9 0.21 11.6 0.5 2.2 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type CpXC PF14353.6 EKE38471.1 - 0.055 13.5 6.6 0.79 9.8 0.1 2.8 1 1 2 3 3 3 0 CpXC protein TF_Zn_Ribbon PF08271.12 EKE38471.1 - 0.059 12.9 8.1 0.63 9.6 0.0 3.5 4 1 0 4 4 4 0 TFIIB zinc-binding FTH PF01827.27 EKE38471.1 - 0.065 13.0 0.7 0.097 12.5 0.7 1.4 1 1 0 1 1 1 0 FTH domain Ogr_Delta PF04606.12 EKE38471.1 - 0.089 12.8 14.4 1.1 9.3 0.2 3.6 2 2 2 4 4 4 0 Ogr/Delta-like zinc finger Baculo_LEF5_C PF11792.8 EKE38471.1 - 0.09 12.5 0.3 0.09 12.5 0.3 2.2 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain Tnp_zf-ribbon_2 PF13842.6 EKE38471.1 - 0.099 13.5 8.8 0.59 11.0 0.2 3.8 4 0 0 4 4 4 0 DDE_Tnp_1-like zinc-ribbon IBR PF01485.21 EKE38471.1 - 0.099 12.9 10.0 5 7.4 5.5 3.1 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain C1_1 PF00130.22 EKE38471.1 - 0.11 12.4 0.8 0.11 12.4 0.8 2.4 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 EKE38471.1 - 0.22 11.6 6.6 2.1 8.4 0.4 2.5 2 1 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 EKE38471.1 - 0.25 10.8 10.1 2 7.9 0.1 3.6 4 0 0 4 4 4 0 zinc-ribbon domain Ribosomal_L37e PF01907.19 EKE38471.1 - 0.28 11.4 0.1 0.28 11.4 0.1 3.2 4 0 0 4 4 4 0 Ribosomal protein L37e zf_UBZ PF18439.1 EKE38471.1 - 0.46 10.1 5.1 14 5.4 0.1 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_2 PF13240.6 EKE38471.1 - 0.96 9.3 0.1 0.96 9.3 0.1 3.6 4 0 0 4 4 4 0 zinc-ribbon domain Ribosomal_S27e PF01667.17 EKE38471.1 - 4.1 7.2 7.6 11 5.9 0.7 3.1 2 2 1 3 3 3 0 Ribosomal protein S27 PhnA_Zn_Ribbon PF08274.12 EKE38471.1 - 5.5 7.0 10.1 3.9 7.5 0.1 3.8 3 1 1 4 4 4 0 PhnA Zinc-Ribbon Lar_restr_allev PF14354.6 EKE38471.1 - 6.9 7.1 11.6 4.8 7.6 0.2 3.1 1 1 2 3 3 3 0 Restriction alleviation protein Lar zf-UBR PF02207.20 EKE38471.1 - 9.3 6.5 10.8 18 5.6 8.5 2.7 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) HIM1 PF08732.10 EKE38472.1 - 6.1e-05 22.6 0.8 9.7e-05 21.9 0.2 1.7 2 0 0 2 2 2 1 HIM1 Arrestin_N PF00339.29 EKE38472.1 - 0.0071 16.4 1.0 0.072 13.1 0.3 2.2 2 1 1 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EKE38472.1 - 0.019 15.5 0.3 1.2 9.5 0.4 2.2 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain DUF5371 PF17341.2 EKE38473.1 - 0.12 12.6 1.1 0.33 11.2 0.6 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5371) TPR_8 PF13181.6 EKE38473.1 - 0.17 12.2 2.2 0.19 12.0 0.5 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Sec7 PF01369.20 EKE38474.1 - 1.1e-12 48.1 0.1 3.9e-12 46.2 0.1 2.0 1 0 0 1 1 1 1 Sec7 domain RIG-I_C-RD PF11648.8 EKE38474.1 - 0.0059 16.8 0.7 0.029 14.6 0.7 2.3 1 0 0 1 1 1 1 C-terminal domain of RIG-I DUF1981 PF09324.10 EKE38474.1 - 0.22 11.4 0.0 0.22 11.4 0.0 5.2 6 0 0 6 6 6 0 Domain of unknown function (DUF1981) IMS PF00817.20 EKE38475.1 - 3.4e-38 131.0 0.0 6.8e-38 130.0 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family BRCT_2 PF16589.5 EKE38475.1 - 3e-12 46.8 0.1 2.4e-11 43.9 0.0 2.5 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain IMS_C PF11799.8 EKE38475.1 - 7.3e-09 36.3 0.0 2e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT PF00533.26 EKE38475.1 - 1.9e-08 34.5 0.1 1.4e-07 31.8 0.1 2.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EKE38475.1 - 2e-07 31.2 0.0 4.7e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain IMS_HHH PF11798.8 EKE38475.1 - 0.00019 21.6 0.1 0.005 17.1 0.0 2.7 2 0 0 2 2 2 1 IMS family HHH motif DUF1805 PF08827.11 EKE38475.1 - 0.013 15.8 0.0 0.03 14.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) PTCB-BRCT PF12738.7 EKE38475.1 - 0.016 15.2 0.0 0.038 13.9 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain Pkinase PF00069.25 EKE38476.1 - 2.7e-49 167.9 4.7 4.2e-49 167.3 4.7 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38476.1 - 4.9e-34 117.8 0.7 6.8e-34 117.3 0.7 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE38476.1 - 2.8e-07 30.2 0.0 1.6e-06 27.7 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EKE38476.1 - 3.9e-05 22.8 8.0 7.4e-05 21.9 8.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EKE38476.1 - 0.00075 18.4 0.0 0.0015 17.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Helicase_C PF00271.31 EKE38477.1 - 2.9e-14 53.3 0.9 1.7e-13 50.9 0.1 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 EKE38477.1 - 2.5e-09 37.4 0.0 2.5e-09 37.4 0.0 3.7 3 1 0 3 3 3 1 Helicase associated domain (HA2) DEAD PF00270.29 EKE38477.1 - 0.00011 22.0 0.3 0.00071 19.4 0.3 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 EKE38477.1 - 0.00074 19.8 0.6 0.0037 17.6 0.2 2.5 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE PF00437.20 EKE38477.1 - 0.0018 17.4 0.0 0.0043 16.2 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EKE38477.1 - 0.013 15.8 0.1 0.065 13.5 0.1 2.2 1 0 0 1 1 1 0 AAA domain dsRBD2 PF17842.1 EKE38477.1 - 0.042 14.0 0.1 0.042 14.0 0.1 4.1 2 1 1 3 3 3 0 Double-stranded RNA binding domain 2 AAA_14 PF13173.6 EKE38477.1 - 4.7 7.2 8.5 0.78 9.8 0.3 3.8 3 1 0 3 3 3 0 AAA domain Apyrase PF06079.11 EKE38478.1 - 1.6e-103 346.0 4.0 1.9e-103 345.7 4.0 1.0 1 0 0 1 1 1 1 Apyrase Rsd_AlgQ PF04353.13 EKE38479.1 - 0.033 14.1 0.0 0.038 13.9 0.0 1.1 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ NYD-SP28 PF14772.6 EKE38479.1 - 0.078 13.0 0.2 0.093 12.8 0.2 1.2 1 0 0 1 1 1 0 Sperm tail RhoGEF PF00621.20 EKE38480.1 - 1.5e-32 113.3 1.2 2.5e-32 112.6 1.2 1.3 1 0 0 1 1 1 1 RhoGEF domain ATP-grasp PF02222.22 EKE38480.1 - 0.13 11.9 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain DUF685 PF05085.12 EKE38481.1 - 0.018 14.4 0.9 1.1 8.5 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF685) PH_10 PF15411.6 EKE38481.1 - 0.08 13.2 2.1 0.3 11.3 1.2 2.3 2 1 0 2 2 2 0 Pleckstrin homology domain RhoGAP PF00620.27 EKE38482.1 - 2.9e-24 85.6 2.7 2.9e-24 85.6 2.7 2.9 4 0 0 4 4 4 1 RhoGAP domain PCO_ADO PF07847.12 EKE38482.1 - 0.0084 15.6 0.1 0.018 14.5 0.1 1.5 1 0 0 1 1 1 1 PCO_ADO Beta_elim_lyase PF01212.21 EKE38483.1 - 7.5e-70 235.5 0.0 9.4e-70 235.2 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 EKE38483.1 - 0.0055 15.4 0.0 0.0084 14.8 0.0 1.2 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Ras PF00071.22 EKE38485.1 - 5.6e-51 172.4 3.8 6.7e-51 172.1 3.8 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38485.1 - 1.4e-28 99.6 1.2 1.4e-28 99.6 1.2 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38485.1 - 8.2e-18 64.4 1.1 9.5e-18 64.2 1.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE38485.1 - 1.4e-08 34.8 0.5 2.1e-08 34.3 0.5 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE38485.1 - 3.4e-08 33.1 0.6 4.9e-08 32.6 0.6 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE38485.1 - 2.4e-07 30.5 1.6 1.1e-06 28.3 0.5 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE38485.1 - 1e-06 28.3 0.8 1.2e-06 28.0 0.8 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE38485.1 - 3.2e-06 27.2 3.6 0.0029 17.5 0.5 2.1 1 1 1 2 2 2 2 RsgA GTPase Septin PF00735.18 EKE38485.1 - 0.00037 19.9 0.4 0.00063 19.1 0.2 1.4 1 1 0 1 1 1 1 Septin PduV-EutP PF10662.9 EKE38485.1 - 0.0025 17.6 0.3 0.024 14.4 0.3 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 EKE38485.1 - 0.0053 16.0 3.9 0.018 14.2 0.8 2.4 1 1 1 2 2 2 1 G-protein alpha subunit FeoB_N PF02421.18 EKE38485.1 - 0.01 15.4 0.2 0.022 14.3 0.2 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_15 PF13175.6 EKE38485.1 - 0.028 14.1 1.6 0.033 13.9 1.6 1.1 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EKE38485.1 - 0.074 13.6 0.6 0.13 12.8 0.6 1.5 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EKE38485.1 - 0.14 12.5 0.1 0.63 10.4 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain Pkinase PF00069.25 EKE38486.1 - 6.7e-57 192.8 0.1 8e-57 192.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38486.1 - 3.4e-20 72.4 0.0 4.9e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EKE38486.1 - 5.5e-05 23.2 0.0 0.00015 21.8 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EKE38486.1 - 0.0014 18.0 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKE38486.1 - 0.086 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kin17_mid PF10357.9 EKE38487.1 - 7.3e-37 126.1 3.0 7.3e-37 126.1 3.0 1.8 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein VD10_N PF08476.10 EKE38487.1 - 0.04 13.6 0.2 0.11 12.2 0.2 1.7 1 0 0 1 1 1 0 Viral D10 N-terminal zf-C2H2_2 PF12756.7 EKE38487.1 - 0.04 14.2 7.6 0.051 13.9 4.0 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Cdc6_C PF09079.11 EKE38487.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain zf-met PF12874.7 EKE38487.1 - 0.13 12.7 6.5 0.32 11.5 6.5 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EKE38487.1 - 0.43 10.9 10.9 0.22 11.8 8.1 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding UpxZ PF06603.11 EKE38488.1 - 8 6.8 9.8 24 5.3 2.2 2.9 2 1 0 2 2 2 0 UpxZ family of transcription anti-terminator antagonists Myb_DNA-binding PF00249.31 EKE38489.1 - 4.1e-07 30.1 0.1 7.4e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain RabGAP-TBC PF00566.18 EKE38490.1 - 1.5e-15 57.5 1.0 3.3e-15 56.3 1.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ribosomal_S9 PF00380.19 EKE38491.1 - 3.3e-34 118.0 0.1 4.2e-34 117.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 VAPB_antitox PF02697.14 EKE38492.1 - 0.0061 17.3 1.7 0.0061 17.3 1.7 2.0 2 1 0 2 2 2 1 Putative antitoxin DUF3449 PF11931.8 EKE38493.1 - 1.3e-56 191.3 1.6 1.3e-56 191.3 1.6 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EKE38493.1 - 1e-16 61.2 0.0 2.2e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-met PF12874.7 EKE38493.1 - 1.8e-07 31.3 8.3 0.00029 21.1 2.8 2.8 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EKE38493.1 - 6.3e-07 29.7 12.6 1.2e-05 25.5 5.0 3.0 2 1 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EKE38493.1 - 1.9e-06 28.0 5.7 1.9e-06 28.0 5.7 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding PRP9_N PF16958.5 EKE38493.1 - 0.0047 17.0 1.5 0.0047 17.0 1.5 2.7 2 1 0 2 2 2 1 Pre-mRNA-splicing factor PRP9 N-terminus zf-C2H2 PF00096.26 EKE38493.1 - 1.2 9.8 10.9 2.5 8.7 0.7 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-U1 PF06220.12 EKE38493.1 - 1.9 8.4 8.9 0.69 9.7 4.2 2.4 2 0 0 2 2 2 0 U1 zinc finger zf-C2H2_4 PF13894.6 EKE38493.1 - 4 8.5 13.6 1.7 9.7 0.5 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger EMP24_GP25L PF01105.24 EKE38494.1 - 1.1e-36 126.4 1.4 1.3e-36 126.3 1.4 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Cluap1 PF10234.9 EKE38494.1 - 0.02 14.3 0.0 0.022 14.2 0.0 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 CSN8_PSD8_EIF3K PF10075.9 EKE38494.1 - 0.027 14.5 0.1 0.13 12.2 0.1 1.8 2 0 0 2 2 2 0 CSN8/PSMD8/EIF3K family Rx_N PF18052.1 EKE38494.1 - 0.031 14.6 0.2 0.058 13.7 0.2 1.4 1 0 0 1 1 1 0 Rx N-terminal domain Ribosomal_L5_C PF00673.21 EKE38495.1 - 3.1e-21 75.3 0.0 4.6e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EKE38495.1 - 6e-19 68.1 0.0 1.1e-18 67.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 RNA_pol_Rpb8 PF03870.15 EKE38496.1 - 7.9e-36 123.3 0.4 8.8e-36 123.2 0.4 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EKE38496.1 - 1.8e-05 24.8 0.6 0.0027 17.8 0.2 2.0 1 1 0 2 2 2 2 DNA-directed RNA polymerase, subunit G TbpB_A PF17484.2 EKE38496.1 - 0.077 13.7 0.0 0.093 13.5 0.0 1.1 1 0 0 1 1 1 0 N-Lobe handle Tf-binding protein B TLD PF07534.16 EKE38497.1 - 0.046 13.9 0.0 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 TLD Slx4 PF09494.10 EKE38498.1 - 8.4e-07 28.8 0.1 3.1e-06 27.0 0.1 1.9 1 0 0 1 1 1 1 Slx4 endonuclease NAD_binding_6 PF08030.12 EKE38498.1 - 0.4 10.8 4.6 0.09 12.9 0.8 1.9 2 0 0 2 2 2 0 Ferric reductase NAD binding domain DUF2039 PF10217.9 EKE38499.1 - 1e-25 89.9 17.6 1e-25 89.9 17.6 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2039) Cript PF10235.9 EKE38499.1 - 0.0002 21.9 8.9 0.0002 21.9 8.9 2.5 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT Tnp_zf-ribbon_2 PF13842.6 EKE38499.1 - 0.087 13.6 12.3 0.12 13.2 8.2 2.7 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon ADK_lid PF05191.14 EKE38499.1 - 0.95 9.5 13.0 2.4 8.2 0.3 3.5 3 1 0 3 3 3 0 Adenylate kinase, active site lid DZR PF12773.7 EKE38499.1 - 9.5 6.3 10.8 2.3e+02 1.9 10.8 2.7 1 1 0 1 1 1 0 Double zinc ribbon DHH PF01368.20 EKE38500.1 - 2.7e-07 30.8 0.2 4.8e-07 29.9 0.2 1.4 1 0 0 1 1 1 1 DHH family DHHA1 PF02272.19 EKE38500.1 - 0.00023 21.6 0.0 0.00069 20.0 0.0 1.8 1 0 0 1 1 1 1 DHHA1 domain Vps39_1 PF10366.9 EKE38500.1 - 0.021 15.1 1.2 3.5 8.0 0.0 2.7 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 InvH PF04741.12 EKE38500.1 - 0.045 13.7 0.4 0.12 12.3 0.2 1.6 1 1 0 1 1 1 0 InvH outer membrane lipoprotein START PF01852.19 EKE38501.1 - 1.6e-25 89.8 0.0 1.9e-25 89.5 0.0 1.0 1 0 0 1 1 1 1 START domain PCYCGC PF13798.6 EKE38502.1 - 0.0051 16.7 0.5 0.01 15.7 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function with PCYCGC motif bZIP_Maf PF03131.17 EKE38503.1 - 3.4e-09 37.1 7.9 4.8e-09 36.6 7.9 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EKE38503.1 - 3.9e-08 33.3 16.3 5.9e-08 32.7 16.3 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EKE38503.1 - 8.5e-07 29.0 13.1 1.6e-06 28.1 13.1 1.5 1 0 0 1 1 1 1 Basic region leucine zipper PEPcase PF00311.17 EKE38503.1 - 0.0077 14.4 2.2 0.0086 14.2 2.2 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase HAUS6_N PF14661.6 EKE38503.1 - 0.011 15.3 5.3 0.014 15.0 5.3 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Exonuc_VII_L PF02601.15 EKE38503.1 - 0.033 13.8 1.9 0.034 13.7 1.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 EKE38503.1 - 0.34 11.0 8.8 0.41 10.7 8.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FapA PF03961.13 EKE38503.1 - 0.63 8.6 8.6 0.78 8.3 8.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A ZapB PF06005.12 EKE38503.1 - 0.92 10.0 11.5 0.24 11.9 7.0 2.0 2 0 0 2 2 2 0 Cell division protein ZapB TSC22 PF01166.18 EKE38503.1 - 2.1 8.7 9.5 0.37 11.1 5.6 1.8 2 0 0 2 2 2 0 TSC-22/dip/bun family DivIC PF04977.15 EKE38503.1 - 7.8 6.3 8.0 1.9 8.3 4.5 1.7 2 0 0 2 2 2 0 Septum formation initiator TMF_DNA_bd PF12329.8 EKE38504.1 - 0.0013 18.7 15.1 0.0027 17.7 15.1 1.6 1 1 0 1 1 1 1 TATA element modulatory factor 1 DNA binding DUF4763 PF15960.5 EKE38504.1 - 0.0019 17.6 6.2 0.0022 17.4 6.2 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4763) DUF3450 PF11932.8 EKE38504.1 - 0.0039 16.5 8.7 0.0053 16.1 8.7 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3450) PKcGMP_CC PF16808.5 EKE38504.1 - 0.0076 16.1 6.9 0.0076 16.1 6.9 2.6 3 0 0 3 3 3 1 Coiled-coil N-terminus of cGMP-dependent protein kinase ATG16 PF08614.11 EKE38504.1 - 0.015 15.5 11.0 0.016 15.5 11.0 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.8 EKE38504.1 - 0.016 15.4 12.8 0.019 15.2 12.8 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding VGPC1_C PF16799.5 EKE38504.1 - 0.032 14.2 5.7 0.032 14.2 5.7 1.5 2 0 0 2 2 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 DUF1664 PF07889.12 EKE38504.1 - 0.044 13.8 6.4 0.057 13.5 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Bap31_Bap29_C PF18035.1 EKE38504.1 - 0.062 13.3 2.3 0.062 13.3 2.3 2.4 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Atg14 PF10186.9 EKE38504.1 - 0.1 11.6 10.4 0.11 11.6 10.4 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Bacillus_HBL PF05791.11 EKE38504.1 - 0.13 12.1 5.8 0.16 11.8 5.8 1.1 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Spc7 PF08317.11 EKE38504.1 - 0.19 10.6 12.4 0.2 10.5 12.4 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein YabA PF06156.13 EKE38504.1 - 0.2 12.3 10.0 0.25 12.0 10.0 1.2 1 0 0 1 1 1 0 Initiation control protein YabA NBP1 PF08537.10 EKE38504.1 - 0.21 11.0 9.9 0.23 10.8 9.9 1.0 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 GIT_CC PF16559.5 EKE38504.1 - 0.21 11.5 4.8 0.1 12.5 1.5 1.9 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Lipoprotein_20 PF13942.6 EKE38504.1 - 0.21 11.5 6.2 0.28 11.1 6.2 1.3 1 0 0 1 1 1 0 YfhG lipoprotein P_C10 PF14974.6 EKE38504.1 - 0.22 11.7 2.5 0.32 11.1 0.4 2.0 1 1 1 2 2 2 0 Protein C10 PilO PF04350.13 EKE38504.1 - 0.22 11.7 7.3 0.26 11.4 7.3 1.2 1 0 0 1 1 1 0 Pilus assembly protein, PilO DUF4279 PF14106.6 EKE38504.1 - 0.22 11.7 2.5 0.31 11.3 2.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4279) Tho2 PF11262.8 EKE38504.1 - 0.23 10.6 9.1 0.24 10.5 9.1 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Exonuc_VII_L PF02601.15 EKE38504.1 - 0.23 11.0 5.7 0.25 10.8 5.7 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Med9 PF07544.13 EKE38504.1 - 0.24 11.5 13.2 0.54 10.4 2.3 2.8 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF641 PF04859.12 EKE38504.1 - 0.31 11.4 9.0 0.58 10.5 9.0 1.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Prominin PF05478.11 EKE38504.1 - 0.31 8.9 4.5 0.33 8.9 4.5 1.0 1 0 0 1 1 1 0 Prominin IZUMO PF15005.6 EKE38504.1 - 0.32 11.5 5.6 2 8.9 2.9 1.9 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Csm1_N PF18504.1 EKE38504.1 - 0.34 11.3 11.9 0.32 11.3 2.0 2.7 1 1 1 2 2 2 0 Csm1 N-terminal domain HalX PF08663.10 EKE38504.1 - 0.43 10.9 8.8 1.1 9.7 9.0 1.6 1 1 0 1 1 1 0 HalX domain SlyX PF04102.12 EKE38504.1 - 0.59 10.8 9.7 0.39 11.4 3.9 2.3 1 1 1 2 2 2 0 SlyX GrpE PF01025.19 EKE38504.1 - 0.88 9.2 9.6 1 9.0 9.5 1.3 1 1 0 1 1 1 0 GrpE TMPIT PF07851.13 EKE38504.1 - 1.2 8.3 7.1 1.2 8.3 7.1 1.0 1 0 0 1 1 1 0 TMPIT-like protein FlaC_arch PF05377.11 EKE38504.1 - 1.2 9.5 8.3 8.5 6.9 4.9 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 EKE38504.1 - 2.9 7.7 15.4 6.7 6.5 2.7 2.9 1 1 1 2 2 2 0 Septum formation initiator Prefoldin PF02996.17 EKE38504.1 - 3.9 7.4 11.8 0.74 9.7 2.4 2.6 1 1 2 3 3 3 0 Prefoldin subunit FapA PF03961.13 EKE38504.1 - 7.9 5.0 11.4 8.2 4.9 11.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_23 PF13476.6 EKE38504.1 - 8.7 6.8 13.0 10 6.6 13.0 1.1 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 EKE38505.1 - 1.2e-42 146.1 0.0 2e-42 145.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38505.1 - 3.6e-21 75.6 0.0 5.7e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE38505.1 - 0.0018 17.7 0.1 0.081 12.2 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EKE38505.1 - 0.028 14.4 0.0 0.22 11.4 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EKE38505.1 - 0.037 13.4 0.0 0.062 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CH PF00307.31 EKE38506.1 - 1.5e-13 50.9 0.1 1.9e-13 50.6 0.1 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain RhoGEF PF00621.20 EKE38507.1 - 5.6e-37 127.7 2.9 9.5e-37 127.0 2.9 1.4 1 0 0 1 1 1 1 RhoGEF domain Yuri_gagarin PF15934.5 EKE38507.1 - 0.035 13.9 0.4 0.078 12.8 0.4 1.5 1 0 0 1 1 1 0 Yuri gagarin DUF3941 PF13081.6 EKE38507.1 - 0.077 13.4 2.1 0.26 11.7 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3941) Adaptin_binding PF10199.9 EKE38508.1 - 3.3e-05 24.5 5.9 0.00031 21.3 5.9 2.2 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Sacchrp_dh_NADP PF03435.18 EKE38508.1 - 0.054 13.8 0.1 0.18 12.1 0.0 1.9 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Pkinase_Tyr PF07714.17 EKE38509.1 - 3.5e-52 177.3 0.0 6.1e-52 176.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38509.1 - 5.8e-51 173.4 0.1 1.3e-50 172.2 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE38509.1 - 1.4e-08 34.0 0.0 2.4e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase VSP PF03302.13 EKE38509.1 - 4.2 6.1 132.5 0.01 14.7 28.4 4.9 1 1 2 4 4 4 0 Giardia variant-specific surface protein VPS9 PF02204.18 EKE38510.1 - 1.1e-13 51.2 1.9 1.5e-13 50.8 0.6 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Bcl-2 PF00452.19 EKE38511.1 - 0.059 14.1 0.1 0.13 12.9 0.0 1.6 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family RIFIN PF02009.16 EKE38512.1 - 0.27 11.1 1.0 0.68 9.8 0.2 1.9 2 0 0 2 2 2 0 Rifin Adaptin_N PF01602.20 EKE38513.1 - 6.4e-45 153.7 21.5 8e-45 153.4 21.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EKE38513.1 - 4.6e-12 46.2 2.0 4.6e-12 46.2 2.0 3.0 3 0 0 3 3 3 1 Adaptin C-terminal domain IFS PF16718.5 EKE38513.1 - 0.13 12.4 0.1 0.13 12.4 0.1 3.5 4 0 0 4 4 4 0 Immunity factor for SPN USP8_interact PF08941.10 EKE38514.1 - 0.03 14.1 2.1 0.05 13.4 1.0 1.9 2 0 0 2 2 2 0 USP8 interacting DASH_Dam1 PF08653.10 EKE38514.1 - 1.4 8.7 4.8 1.5 8.7 1.8 2.6 2 0 0 2 2 2 0 DASH complex subunit Dam1 DUF3037 PF11236.8 EKE38515.1 - 0.0035 17.8 0.7 0.0035 17.8 0.7 4.8 2 1 2 4 4 4 1 Protein of unknown function (DUF3037) ATG16 PF08614.11 EKE38515.1 - 0.17 12.1 100.2 0.15 12.3 16.1 5.4 1 1 4 5 5 5 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 EKE38515.1 - 0.25 11.4 126.9 0.063 13.3 19.1 5.7 1 1 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.19 EKE38515.1 - 0.27 11.0 102.5 0.055 13.3 38.3 3.8 1 1 2 3 3 3 0 Ezrin/radixin/moesin family CH PF00307.31 EKE38516.1 - 4.7e-14 52.5 0.8 5.9e-14 52.2 0.8 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EKE38516.1 - 0.0083 15.9 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain Glycos_transf_2 PF00535.26 EKE38516.1 - 0.016 15.1 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Ufd2P_core PF10408.9 EKE38517.1 - 4.7e-89 299.7 34.0 4.7e-89 299.7 34.0 2.1 2 1 0 2 2 2 1 Ubiquitin elongating factor core U-box PF04564.15 EKE38517.1 - 5.1e-21 74.6 1.5 8.3e-21 74.0 0.6 1.9 2 0 0 2 2 2 1 U-box domain Pox_polyA_pol PF03296.13 EKE38517.1 - 0.015 15.2 4.5 0.067 13.1 4.5 2.2 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase nucleotidyltransferase domain RasGEF PF00617.19 EKE38518.1 - 4.7e-17 62.7 2.9 4.7e-17 62.7 2.9 2.6 3 0 0 3 3 3 1 RasGEF domain Ndr PF03096.14 EKE38518.1 - 0.026 13.2 0.0 0.054 12.2 0.0 1.4 1 0 0 1 1 1 0 Ndr family DUF3615 PF12274.8 EKE38518.1 - 0.32 11.5 0.1 0.32 11.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3615) Peptidase_S9 PF00326.21 EKE38520.1 - 3.6e-23 82.2 0.0 6.2e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 EKE38520.1 - 1.2e-06 28.3 1.4 0.013 15.5 0.2 4.0 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Esterase PF00756.20 EKE38520.1 - 0.0066 16.1 0.2 1.1 8.8 0.0 2.2 2 0 0 2 2 2 2 Putative esterase Abhydrolase_1 PF00561.20 EKE38520.1 - 0.0092 15.7 0.2 0.022 14.4 0.2 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EKE38520.1 - 0.05 12.5 0.0 0.08 11.8 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme TCR PF03638.15 EKE38521.1 - 1.1e-06 28.8 24.3 1.7e-06 28.2 24.3 1.3 1 0 0 1 1 1 1 Tesmin/TSO1-like CXC domain, cysteine-rich domain YqzH PF14164.6 EKE38521.1 - 0.059 13.4 0.1 0.059 13.4 0.1 2.0 3 0 0 3 3 3 0 YqzH-like protein MSL2-CXC PF16682.5 EKE38521.1 - 0.35 11.0 19.0 0.54 10.4 19.0 1.3 1 0 0 1 1 1 0 CXC domain of E3 ubiquitin-protein ligase MSL2 Ribosomal_L7Ae PF01248.26 EKE38522.1 - 2.8e-21 75.1 3.4 3.4e-21 74.8 3.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family MIF4G PF02854.19 EKE38523.1 - 1.2e-11 44.7 7.1 2.2e-11 43.8 7.1 1.4 1 0 0 1 1 1 1 MIF4G domain RnlB_antitoxin PF15933.5 EKE38523.1 - 0.045 14.0 3.5 0.088 13.1 1.4 2.5 1 1 2 3 3 3 0 Antitoxin to bacterial toxin RNase LS or RnlA Pkinase PF00069.25 EKE38524.1 - 1.9e-45 155.3 0.1 2.4e-42 145.1 0.2 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38524.1 - 5.7e-26 91.4 0.1 2.6e-25 89.2 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase FTA2 PF13095.6 EKE38524.1 - 0.068 12.8 1.7 0.18 11.4 0.2 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EKE38524.1 - 0.072 11.8 0.1 0.11 11.2 0.1 1.2 1 0 0 1 1 1 0 Fungal protein kinase Lebercilin PF15619.6 EKE38525.1 - 0.0052 16.5 38.2 0.0052 16.5 38.2 3.7 2 2 1 3 3 3 1 Ciliary protein causing Leber congenital amaurosis disease CCD48 PF15799.5 EKE38525.1 - 0.096 11.0 10.6 0.14 10.4 10.3 1.5 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 48 T2SSG PF08334.11 EKE38525.1 - 0.23 11.5 4.0 0.17 12.0 0.3 2.6 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein G HAP1_N PF04849.13 EKE38525.1 - 1.8 7.7 63.6 0.023 13.9 14.8 3.2 1 1 2 3 3 3 0 HAP1 N-terminal conserved region Phage_sheath_1N PF17481.2 EKE38525.1 - 2.7 8.5 4.9 17 5.9 4.5 2.7 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain DUF641 PF04859.12 EKE38525.1 - 4.4 7.7 50.5 0.56 10.6 10.4 4.6 2 2 2 4 4 4 0 Plant protein of unknown function (DUF641) TMPIT PF07851.13 EKE38525.1 - 8.3 5.5 52.1 0.1 11.8 12.0 3.2 1 1 2 3 3 3 0 TMPIT-like protein MCC-bdg_PDZ PF10506.9 EKE38525.1 - 8.6 6.5 13.9 0.2 11.7 0.7 4.1 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Beta_helix PF13229.6 EKE38526.1 - 1.1e-25 90.3 15.0 3.9e-14 52.8 7.5 2.5 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.13 EKE38526.1 - 3.8e-20 72.2 0.8 1.6e-09 37.4 0.2 3.1 1 1 2 3 3 3 3 Periplasmic copper-binding protein (NosD) DUF4957 PF16318.5 EKE38526.1 - 4.7e-06 26.6 1.3 4.7e-06 26.6 1.3 3.8 3 2 1 4 4 4 1 Domain of unknown function (DUF4957) Pectate_lyase_3 PF12708.7 EKE38526.1 - 8e-05 22.6 9.9 0.00017 21.5 0.5 3.8 3 1 1 4 4 4 2 Pectate lyase superfamily protein DUF1565 PF07602.11 EKE38526.1 - 0.0033 16.8 11.7 0.0069 15.7 4.9 3.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1565) Pmp3 PF01679.17 EKE38527.1 - 1.3e-05 25.3 8.0 1.5e-05 25.0 8.0 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF1145 PF06611.12 EKE38527.1 - 0.12 12.3 0.8 0.2 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1145) Sas10_Utp3 PF04000.15 EKE38528.1 - 2.2e-08 34.6 0.9 2.2e-08 34.6 0.9 2.6 3 0 0 3 3 3 1 Sas10/Utp3/C1D family YgaB PF14182.6 EKE38528.1 - 0.0032 17.8 5.6 0.025 14.9 0.1 2.6 2 0 0 2 2 2 1 YgaB-like protein IL13 PF03487.13 EKE38528.1 - 0.01 15.6 0.7 0.048 13.4 0.0 2.0 2 0 0 2 2 2 0 Interleukin-13 TPR_MLP1_2 PF07926.12 EKE38528.1 - 0.021 14.9 5.6 0.89 9.6 1.8 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4709 PF15821.5 EKE38528.1 - 0.19 12.1 4.9 0.21 11.9 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4709) DivIC PF04977.15 EKE38528.1 - 7.8 6.3 11.1 1.8 8.4 2.4 3.0 3 0 0 3 3 3 0 Septum formation initiator RasGAP PF00616.19 EKE38529.1 - 3.6e-15 56.2 6.2 2.8e-14 53.3 0.2 3.0 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase SF3A3 PF16837.5 EKE38529.1 - 0.28 11.7 3.6 0.21 12.2 0.6 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 YIF1 PF03878.15 EKE38530.1 - 3.8e-55 187.0 14.8 4.7e-55 186.7 14.8 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 EKE38530.1 - 0.0015 18.2 9.6 0.0028 17.4 9.6 1.5 1 0 0 1 1 1 1 Yip1 domain zf-U1 PF06220.12 EKE38531.1 - 1.5e-09 37.5 6.1 2e-09 37.0 6.1 1.2 1 0 0 1 1 1 1 U1 zinc finger zf-BED PF02892.15 EKE38531.1 - 0.018 15.1 2.6 0.031 14.3 2.6 1.4 1 0 0 1 1 1 0 BED zinc finger zf-C2H2_jaz PF12171.8 EKE38531.1 - 0.04 14.2 9.9 0.73 10.2 2.4 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Adaptin_N PF01602.20 EKE38532.1 - 3.3e-70 237.1 8.9 4.1e-70 236.8 8.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EKE38532.1 - 9.3e-06 25.8 8.4 0.027 14.5 0.7 4.0 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Alpha_adaptinC2 PF02883.20 EKE38532.1 - 0.00044 20.5 1.4 0.0011 19.3 1.4 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Vac14_Fab1_bd PF12755.7 EKE38532.1 - 0.0039 17.8 0.4 1.6 9.4 0.0 3.1 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 EKE38532.1 - 0.0048 17.1 0.3 17 6.0 0.0 4.0 3 0 0 3 3 3 1 HEAT repeat DUF2547 PF10818.8 EKE38532.1 - 0.45 11.5 6.2 23 6.0 2.4 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2547) GpcrRhopsn4 PF10192.9 EKE38533.1 - 1.4e-06 27.9 18.4 1.4e-06 27.9 18.4 2.6 3 0 0 3 3 3 2 Rhodopsin-like GPCR transmembrane domain DUF2757 PF10955.8 EKE38534.1 - 0.097 12.9 1.5 0.9 9.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2757) zinc_ribbon_4 PF13717.6 EKE38534.1 - 0.18 11.7 4.5 2.8 7.9 0.8 2.7 2 0 0 2 2 2 0 zinc-ribbon domain Zn_ribbon_SprT PF17283.2 EKE38534.1 - 0.26 11.2 0.4 0.26 11.2 0.4 3.2 2 1 1 3 3 3 0 SprT-like zinc ribbon domain zinc_ribbon_10 PF10058.9 EKE38534.1 - 0.5 10.1 5.9 6.4 6.6 0.2 2.4 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-HIT PF04438.16 EKE38534.1 - 1.3 8.9 10.5 5.6 6.9 0.8 2.4 2 1 0 2 2 2 0 HIT zinc finger Zn_Tnp_IS1595 PF12760.7 EKE38534.1 - 2.1 8.4 8.8 1.9 8.5 1.9 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 EKE38534.1 - 2.2 8.9 6.6 4.2 8.0 0.5 3.1 3 0 0 3 3 3 0 Zinc-finger double domain Zn-ribbon_8 PF09723.10 EKE38534.1 - 7.6 6.7 7.7 21 5.4 1.1 2.7 3 1 0 3 3 3 0 Zinc ribbon domain zf_UBZ PF18439.1 EKE38534.1 - 7.8 6.2 8.3 8.8 6.0 0.4 3.3 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Peptidase_S74 PF13884.6 EKE38535.1 - 1.8e-13 50.6 0.0 4.4e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 Chaperone of endosialidase COPIIcoated_ERV PF07970.12 EKE38536.1 - 9.7e-34 117.1 0.9 1.7e-33 116.4 0.9 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EKE38536.1 - 7.6e-21 74.3 0.5 1.5e-20 73.3 0.5 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Proteasome PF00227.26 EKE38537.1 - 8e-43 146.1 0.1 1.1e-42 145.7 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EKE38537.1 - 3.5e-14 52.2 0.9 6.3e-14 51.3 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RNA_pol_A_bac PF01000.26 EKE38537.1 - 0.087 13.2 0.1 0.15 12.5 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb3/RpoA insert domain WD40 PF00400.32 EKE38538.1 - 0.031 15.2 0.4 27 5.8 0.0 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat RhoGEF PF00621.20 EKE38539.1 - 9.1e-23 81.4 10.5 2.4e-22 80.1 10.5 1.8 1 0 0 1 1 1 1 RhoGEF domain DUF547 PF04784.14 EKE38540.1 - 3e-17 62.8 0.0 1.2e-16 60.9 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function, DUF547 PTEN_C2 PF10409.9 EKE38540.1 - 4.6e-14 52.3 3.2 3.5e-13 49.5 3.2 2.2 1 1 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 EKE38540.1 - 5e-05 23.1 0.1 0.00018 21.3 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 EKE38540.1 - 0.00018 21.2 0.0 0.0004 20.1 0.0 1.6 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 EKE38540.1 - 0.00024 20.7 0.0 0.00052 19.6 0.0 1.6 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EKE38540.1 - 0.00052 20.0 0.2 0.0015 18.6 0.0 1.8 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EKE38540.1 - 0.0028 17.8 0.0 0.0068 16.5 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate HEPN_Toprim_N PF18871.1 EKE38540.1 - 0.1 12.5 0.2 0.27 11.2 0.0 1.7 2 0 0 2 2 2 0 HEPN/Toprim N-terminal domain 1 DUF1843 PF08898.10 EKE38542.1 - 0.16 12.5 3.0 0.93 10.0 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) YvrJ PF12841.7 EKE38542.1 - 7.8 6.1 6.4 2.5 7.7 0.2 3.1 3 0 0 3 3 3 0 YvrJ protein family Myb_DNA-bind_7 PF15963.5 EKE38543.1 - 1.2e-16 60.3 1.0 2.2e-16 59.5 0.3 1.8 1 1 1 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EKE38543.1 - 4.3e-06 26.8 0.0 1.1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain CAP59_mtransfer PF11735.8 EKE38544.1 - 0.02 14.6 0.5 4.1 7.0 0.2 2.5 3 0 0 3 3 3 0 Cryptococcal mannosyltransferase 1 IKBKB_SDD PF18397.1 EKE38544.1 - 0.036 13.4 0.2 0.089 12.1 0.1 1.6 1 1 0 1 1 1 0 IQBAL scaffold dimerization domain Ribosomal_L18 PF17135.4 EKE38545.1 - 0.038 13.4 0.0 0.041 13.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein 60S L18 and 50S L18e DUF676 PF05057.14 EKE38546.1 - 1.5e-24 86.7 0.0 2.5e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EKE38546.1 - 0.0073 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 EKE38546.1 - 0.072 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) SpvB PF03534.13 EKE38546.1 - 0.12 11.6 0.1 0.19 10.9 0.1 1.3 1 0 0 1 1 1 0 Salmonella virulence plasmid 65kDa B protein Nitroreductase PF00881.24 EKE38547.1 - 4.5e-17 62.6 0.0 5.7e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family Fer4_10 PF13237.6 EKE38547.1 - 7.1e-07 29.3 14.1 7.1e-07 29.3 14.1 1.8 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4 PF00037.27 EKE38547.1 - 6.6e-06 25.7 23.7 3.2e-05 23.6 5.4 2.8 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EKE38547.1 - 1.6e-05 24.7 16.1 0.00024 21.0 2.9 3.1 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_9 PF13187.6 EKE38547.1 - 2.4e-05 24.4 14.5 2.4e-05 24.4 14.5 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain TM1586_NiRdase PF14512.6 EKE38547.1 - 4.4e-05 23.1 0.8 0.041 13.4 0.3 3.0 1 1 1 2 2 2 1 Putative TM nitroreductase Fer4_21 PF14697.6 EKE38547.1 - 0.00017 21.7 12.9 0.00017 21.7 12.9 2.4 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EKE38547.1 - 0.0003 21.3 19.4 0.00068 20.2 16.4 2.8 2 1 2 4 4 4 3 4Fe-4S dicluster domain Fer4_16 PF13484.6 EKE38547.1 - 0.001 20.0 16.1 0.022 15.7 1.8 3.3 4 0 0 4 4 3 2 4Fe-4S double cluster binding domain Fer4_6 PF12837.7 EKE38547.1 - 0.0012 18.9 14.2 0.0021 18.0 4.7 3.3 5 0 0 5 5 3 2 4Fe-4S binding domain Fer4_15 PF13459.6 EKE38547.1 - 0.011 16.5 2.2 0.011 16.5 2.2 2.7 1 1 1 2 2 2 0 4Fe-4S single cluster domain Fer4_22 PF17179.4 EKE38547.1 - 0.22 12.4 16.3 0.74 10.7 0.5 2.7 3 0 0 3 3 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 EKE38547.1 - 1.3 9.7 22.3 0.088 13.4 3.7 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_8 PF13183.6 EKE38547.1 - 1.7 9.1 23.6 1.2 9.6 17.0 2.7 2 1 1 3 3 3 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 EKE38547.1 - 6.9 7.3 16.5 2.8 8.6 4.6 2.8 1 1 1 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I DXP_synthase_N PF13292.6 EKE38548.1 - 0.062 12.5 3.1 0.12 11.5 3.1 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase AP1AR PF15745.5 EKE38548.1 - 0.15 11.7 4.6 0.24 11.0 4.6 1.3 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein DUF3106 PF11304.8 EKE38548.1 - 0.35 11.4 3.2 0.81 10.2 3.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) BLOC1_2 PF10046.9 EKE38548.1 - 0.63 10.4 14.0 0.49 10.7 9.5 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Syntaxin-6_N PF09177.11 EKE38548.1 - 2.9 8.5 11.4 9.7 6.8 5.1 2.5 2 0 0 2 2 2 0 Syntaxin 6, N-terminal PRKCSH-like PF12999.7 EKE38548.1 - 6 6.6 13.4 0.48 10.2 7.9 2.0 2 1 0 2 2 2 0 Glucosidase II beta subunit-like SH2_2 PF14633.6 EKE38549.1 - 6.7e-14 51.8 0.1 7.8e-14 51.6 0.1 1.0 1 0 0 1 1 1 1 SH2 domain MutS_IV PF05190.18 EKE38549.1 - 0.049 14.0 0.4 0.16 12.3 0.0 1.8 2 0 0 2 2 2 0 MutS family domain IV Peptidase_C54 PF03416.19 EKE38550.1 - 5.3e-22 78.5 0.0 7.5e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 EKE38550.1 - 1e-05 25.1 0.1 0.00046 19.7 0.0 2.2 2 0 0 2 2 2 2 Peptidase family C78 Peptidase_C54 PF03416.19 EKE38551.1 - 2.2e-14 53.5 0.1 2.6e-14 53.3 0.1 1.1 1 0 0 1 1 1 1 Peptidase family C54 PRP38 PF03371.15 EKE38553.1 - 2.2e-45 154.6 3.2 2.7e-45 154.4 3.2 1.1 1 0 0 1 1 1 1 PRP38 family DSPc PF00782.20 EKE38554.1 - 1.2e-27 96.4 0.1 2.7e-27 95.2 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Gelsolin PF00626.22 EKE38554.1 - 0.00032 20.6 1.0 0.0012 18.7 0.0 2.4 3 0 0 3 3 3 1 Gelsolin repeat Y_phosphatase PF00102.27 EKE38554.1 - 0.00052 19.6 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EKE38554.1 - 0.088 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain PUF PF00806.19 EKE38557.1 - 3.3e-61 199.7 24.4 8.8e-10 37.7 0.1 9.1 8 1 0 9 9 9 8 Pumilio-family RNA binding repeat DUF445 PF04286.12 EKE38557.1 - 0.022 14.6 5.2 2.6 7.8 3.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF445) SapB_2 PF03489.17 EKE38557.1 - 3.9 7.7 7.6 7 6.9 0.2 4.3 5 0 0 5 5 5 0 Saposin-like type B, region 2 UDPGP PF01704.18 EKE38558.1 - 1.3e-155 518.2 4.9 1.5e-155 517.9 4.9 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase YcgL PF05166.13 EKE38558.1 - 0.057 13.8 0.0 0.2 12.0 0.0 1.9 1 0 0 1 1 1 0 YcgL domain SapB_1 PF05184.15 EKE38558.1 - 0.33 11.0 3.3 0.44 10.6 0.5 2.7 2 0 0 2 2 2 0 Saposin-like type B, region 1 ComC PF03047.14 EKE38558.1 - 0.45 10.4 3.4 31 4.5 0.2 3.6 3 0 0 3 3 3 0 COMC family Rap_GAP PF02145.15 EKE38559.1 - 1.1e-56 191.4 0.3 1.6e-56 190.8 0.3 1.3 1 0 0 1 1 1 1 Rap/ran-GAP Fe-ADH PF00465.19 EKE38561.1 - 1.3e-51 175.6 0.0 1.5e-51 175.4 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EKE38561.1 - 1e-06 28.7 0.3 4.2e-05 23.4 0.0 2.1 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase BPL_LplA_LipB PF03099.19 EKE38562.1 - 1.6e-14 54.0 0.1 2.6e-14 53.3 0.1 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DUF3242 PF11586.8 EKE38562.1 - 1.6 8.5 5.4 2 8.1 0.1 2.8 2 2 1 3 3 3 0 Protein of unknown function (DUF3242) Insulin_TMD PF17870.1 EKE38563.1 - 0.0054 16.8 7.5 0.014 15.4 7.5 1.7 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment Saf_2TM PF18303.1 EKE38563.1 - 0.041 13.5 4.1 0.053 13.1 1.9 1.9 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain CRIC_ras_sig PF10534.9 EKE38563.1 - 0.051 13.8 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Connector enhancer of kinase suppressor of ras DUF3377 PF11857.8 EKE38563.1 - 0.06 13.3 4.3 0.15 12.0 4.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Cortexin PF11057.8 EKE38563.1 - 0.07 13.0 2.1 0.13 12.1 2.1 1.5 1 0 0 1 1 1 0 Cortexin of kidney DUF2207 PF09972.9 EKE38563.1 - 0.3 9.8 1.9 0.36 9.6 1.9 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) TMEM154 PF15102.6 EKE38563.1 - 0.3 11.0 9.0 0.032 14.1 4.4 1.7 2 0 0 2 2 2 0 TMEM154 protein family OAD_gamma PF04277.13 EKE38563.1 - 0.32 11.6 6.4 0.33 11.6 3.2 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Orf78 PF06024.12 EKE38563.1 - 1.3 9.4 7.3 2.4 8.5 7.2 1.7 1 1 0 1 1 1 0 Orf78 (ac78) Baculo_11_kDa PF06143.11 EKE38563.1 - 1.3 8.6 8.1 0.33 10.6 3.6 2.0 2 0 0 2 2 2 0 Baculovirus 11 kDa family EVI2A PF05399.11 EKE38563.1 - 9.7 5.7 11.6 2.2 7.8 7.9 1.6 1 1 1 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) SH3_1 PF00018.28 EKE38564.1 - 2e-15 56.1 2.2 4.1e-15 55.1 0.1 2.6 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EKE38564.1 - 4.8e-15 55.2 0.7 1.1e-14 54.0 0.0 2.1 3 0 0 3 3 3 1 Variant SH3 domain SH3_2 PF07653.17 EKE38564.1 - 2.2e-11 43.2 0.0 7.5e-11 41.5 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain tRNA-synt_His PF13393.6 EKE38565.1 - 6e-45 153.8 0.0 9.9e-45 153.1 0.0 1.3 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EKE38565.1 - 9.4e-11 41.7 0.1 2.6e-10 40.3 0.1 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.20 EKE38565.1 - 1.3e-05 24.5 0.1 0.00014 21.1 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) HGTP_anticodon2 PF12745.7 EKE38565.1 - 0.0018 17.9 0.3 0.0018 17.9 0.3 1.6 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs tRNA-synt_2d PF01409.20 EKE38565.1 - 0.0068 15.9 0.1 0.03 13.8 0.0 2.0 2 1 0 2 2 2 1 tRNA synthetases class II core domain (F) IF4E PF01652.18 EKE38567.1 - 8e-46 155.7 1.9 9.6e-46 155.5 1.9 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E U79_P34 PF03064.16 EKE38568.1 - 0.00017 21.0 11.3 0.0003 20.2 11.3 1.4 1 1 0 1 1 1 1 HSV U79 / HCMV P34 GSH_synthase PF03199.15 EKE38568.1 - 0.12 12.9 3.4 0.32 11.5 3.4 1.8 1 1 0 1 1 1 0 Eukaryotic glutathione synthase HIP1_clath_bdg PF16515.5 EKE38568.1 - 0.2 12.3 7.7 0.52 10.9 7.1 1.9 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4337 PF14235.6 EKE38568.1 - 0.35 11.0 4.8 0.43 10.7 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) AP3D1 PF06375.11 EKE38568.1 - 0.63 10.3 10.7 0.79 9.9 10.7 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 ApoA-II PF04711.13 EKE38568.1 - 1.2 9.4 5.1 0.87 9.8 2.1 2.1 2 0 0 2 2 2 0 Apolipoprotein A-II (ApoA-II) Ribosomal_60s PF00428.19 EKE38569.1 - 1.2e-18 67.5 18.7 1.3e-18 67.3 18.7 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein PepSY_2 PF13670.6 EKE38569.1 - 0.01 15.8 5.1 1 9.4 1.2 2.2 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain DUF2992 PF11208.8 EKE38569.1 - 0.019 15.2 0.9 0.023 14.9 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Pro-MCH PF05824.12 EKE38569.1 - 0.073 13.0 0.2 0.097 12.6 0.2 1.3 1 0 0 1 1 1 0 Pro-melanin-concentrating hormone (Pro-MCH) Cytomega_UL84 PF06284.11 EKE38569.1 - 0.22 9.9 4.2 0.24 9.8 4.2 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF3824 PF12868.7 EKE38569.1 - 0.28 11.8 4.3 0.41 11.3 4.3 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) PCI PF01399.27 EKE38570.1 - 3e-23 82.3 0.4 3e-23 82.3 0.4 2.5 3 0 0 3 3 3 1 PCI domain Rpn3_C PF08375.11 EKE38570.1 - 3e-07 30.8 0.0 5.9e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal EOS1 PF12326.8 EKE38570.1 - 0.77 9.7 3.9 1.7 8.5 3.8 1.5 1 1 0 1 1 1 0 N-glycosylation protein TPR_2 PF07719.17 EKE38570.1 - 0.79 10.0 5.5 0.71 10.1 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Methyltransf_31 PF13847.6 EKE38571.1 - 6.9e-09 35.7 0.1 8.5e-09 35.4 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE38571.1 - 3.5e-08 34.0 0.0 4.7e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EKE38571.1 - 0.00011 21.7 0.0 0.00014 21.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 EKE38571.1 - 0.00017 21.4 0.0 0.00025 20.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EKE38571.1 - 0.00027 20.5 0.0 0.00039 19.9 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_11 PF08241.12 EKE38571.1 - 0.00031 21.4 0.0 0.00043 20.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EKE38571.1 - 0.00032 20.4 0.2 0.00042 20.0 0.2 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.12 EKE38571.1 - 0.00038 21.1 0.0 0.00053 20.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EKE38571.1 - 0.00049 19.5 0.0 0.00064 19.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 EKE38571.1 - 0.0011 18.9 0.1 0.0016 18.4 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EKE38571.1 - 0.0011 18.9 0.0 0.0016 18.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKE38571.1 - 0.0012 18.7 0.0 0.0014 18.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EKE38571.1 - 0.0013 18.3 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 MTS PF05175.14 EKE38571.1 - 0.013 15.1 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EKE38571.1 - 0.023 14.0 0.4 0.053 12.8 0.3 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family TehB PF03848.14 EKE38571.1 - 0.073 12.5 2.0 0.18 11.2 2.0 1.7 1 1 0 1 1 1 0 Tellurite resistance protein TehB UPF0146 PF03686.13 EKE38571.1 - 0.16 11.9 0.4 0.49 10.3 0.4 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0146) Cullin_Nedd8 PF10557.9 EKE38572.1 - 9.1e-05 22.4 1.7 9.1e-05 22.4 1.7 2.9 3 0 0 3 3 3 1 Cullin protein neddylation domain Arm PF00514.23 EKE38573.1 - 2.1e-06 27.6 0.7 5.1 7.3 0.0 6.5 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat AnkUBD PF18418.1 EKE38573.1 - 0.054 13.6 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 Ankyrin ubiquitin-binding domain BSMAP PF12280.8 EKE38573.1 - 0.086 13.0 1.0 0.32 11.2 0.1 2.3 2 1 1 3 3 3 0 Brain specific membrane anchored protein SKA2 PF16740.5 EKE38574.1 - 0.0004 20.1 2.3 0.0051 16.6 2.5 2.2 1 1 1 2 2 2 1 Spindle and kinetochore-associated protein 2 Suppressor_APC PF11414.8 EKE38574.1 - 0.0019 18.2 1.0 0.003 17.6 0.2 1.8 2 0 0 2 2 2 1 Adenomatous polyposis coli tumour suppressor protein Sec20 PF03908.13 EKE38574.1 - 0.0031 17.4 2.7 0.0033 17.3 0.2 2.1 2 1 0 2 2 2 1 Sec20 V-SNARE_C PF12352.8 EKE38574.1 - 0.0034 17.6 0.8 0.008 16.4 0.8 1.6 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus DUF4407 PF14362.6 EKE38574.1 - 0.042 13.2 0.4 0.054 12.8 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2730 PF10805.8 EKE38574.1 - 0.16 12.0 3.6 7.8 6.6 0.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF2730) APG6_N PF17675.1 EKE38574.1 - 0.42 11.1 5.3 0.53 10.8 4.2 1.9 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF3802 PF12290.8 EKE38574.1 - 1.1 9.8 7.5 1.7 9.2 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3802) UPF0242 PF06785.11 EKE38574.1 - 2.4 8.2 10.8 0.044 13.9 3.9 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus JIP_LZII PF16471.5 EKE38574.1 - 6.2 7.1 10.3 0.72 10.1 2.6 3.1 3 1 0 3 3 3 0 JNK-interacting protein leucine zipper II Dopey_N PF04118.14 EKE38575.1 - 8.1e-31 107.3 0.0 9.5e-31 107.0 0.0 1.0 1 0 0 1 1 1 1 Dopey, N-terminal PLA2_B PF01735.18 EKE38575.1 - 0.037 12.4 0.0 0.042 12.2 0.0 1.1 1 0 0 1 1 1 0 Lysophospholipase catalytic domain Dopey_N PF04118.14 EKE38576.1 - 1.7e-20 73.4 3.3 1.7e-20 73.4 3.3 2.8 2 2 0 2 2 2 2 Dopey, N-terminal Imm30 PF15565.6 EKE38576.1 - 0.3 11.2 6.9 0.1 12.7 3.0 2.3 2 0 0 2 2 2 0 Immunity protein 30 eIF2A PF08662.11 EKE38577.1 - 1.9e-09 37.7 3.7 5.7e-08 32.9 0.3 4.2 1 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EKE38577.1 - 0.0061 16.3 0.3 0.02 14.7 0.3 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 EKE38577.1 - 0.034 15.0 0.7 16 6.5 0.1 4.1 4 0 0 4 4 4 0 WD domain, G-beta repeat Fib_alpha PF08702.10 EKE38578.1 - 0.39 10.9 9.6 0.055 13.6 4.3 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ADIP PF11559.8 EKE38578.1 - 0.89 9.6 18.4 2.8 8.0 18.5 1.7 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF676 PF05057.14 EKE38578.1 - 1.7 8.1 4.8 2 7.8 4.8 1.0 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF4407 PF14362.6 EKE38578.1 - 2.6 7.3 11.5 2.9 7.2 11.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 EKE38578.1 - 5.2 7.8 17.8 5.6 7.7 17.8 1.0 1 0 0 1 1 1 0 Initiation control protein YabA HAUS6_N PF14661.6 EKE38578.1 - 5.2 6.6 17.0 5.7 6.5 17.0 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF16 PF01519.16 EKE38578.1 - 6 7.4 16.4 29 5.2 16.4 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 Gelsolin PF00626.22 EKE38579.1 - 1.7e-52 175.2 4.3 1.5e-10 40.8 0.0 7.7 7 0 0 7 7 7 7 Gelsolin repeat LRR_8 PF13855.6 EKE38579.1 - 2.4e-20 72.1 75.2 2.4e-08 33.6 2.4 4.8 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EKE38579.1 - 9.2e-16 57.7 57.9 5.5e-06 26.6 7.4 6.8 1 1 7 9 9 9 9 Leucine Rich repeats (2 copies) VHP PF02209.19 EKE38579.1 - 2.3e-14 53.2 2.2 7.9e-14 51.4 2.2 2.1 1 0 0 1 1 1 1 Villin headpiece domain LRR_9 PF14580.6 EKE38579.1 - 0.35 10.3 28.1 0.65 9.5 3.2 4.3 2 1 2 4 4 4 0 Leucine-rich repeat LIM PF00412.22 EKE38580.1 - 3.4e-15 56.0 26.2 8.4e-11 41.9 6.4 2.5 2 1 0 2 2 2 2 LIM domain NinD PF17466.2 EKE38580.1 - 0.035 14.2 7.1 3.4 7.8 0.8 3.5 3 0 0 3 3 3 0 Family of unknown function Ephrin_rec_like PF07699.13 EKE38580.1 - 5.7 6.8 22.9 0.12 12.2 2.5 3.5 4 0 0 4 4 4 0 Putative ephrin-receptor like LCAT PF02450.15 EKE38582.1 - 7e-44 150.6 2.2 7.9e-39 133.9 0.8 2.4 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EKE38582.1 - 0.0001 21.9 0.0 0.00019 21.0 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EKE38582.1 - 0.00013 21.8 0.0 0.00027 20.7 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 EKE38582.1 - 0.0023 17.8 0.0 0.0044 16.9 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_1 PF00561.20 EKE38582.1 - 0.0089 15.7 0.1 0.042 13.5 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Lipase_2 PF01674.18 EKE38582.1 - 0.021 14.3 0.0 0.037 13.5 0.0 1.4 1 1 0 1 1 1 0 Lipase (class 2) LIDHydrolase PF10230.9 EKE38582.1 - 0.035 13.7 0.0 0.072 12.6 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase CbiX PF01903.17 EKE38582.1 - 0.048 14.0 0.0 0.15 12.4 0.0 1.8 2 0 0 2 2 2 0 CbiX Ser_hydrolase PF06821.13 EKE38582.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase Pkinase_Tyr PF07714.17 EKE38583.1 - 8.2e-31 107.2 1.1 2e-30 106.0 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38583.1 - 2.9e-25 89.1 0.2 7.5e-25 87.8 0.2 1.6 1 0 0 1 1 1 1 Protein kinase domain Ago_N_1 PF18351.1 EKE38584.1 - 0.16 12.4 2.8 0.12 12.8 0.9 1.8 2 0 0 2 2 2 0 Fungal Argonaute N-terminal domain eIF3_N PF09440.10 EKE38586.1 - 0.061 13.8 0.5 0.34 11.3 0.2 2.1 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain YtxH PF12732.7 EKE38586.1 - 5 7.7 5.5 1.3e+02 3.2 5.5 2.4 1 1 0 1 1 1 0 YtxH-like protein Lipocalin_3 PF12702.7 EKE38587.1 - 0.025 14.7 0.7 0.072 13.2 0.1 2.0 3 0 0 3 3 3 0 Lipocalin-like S4_2 PF13275.6 EKE38587.1 - 0.06 13.2 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 S4 domain FAM177 PF14774.6 EKE38588.1 - 0.096 13.1 1.1 0.44 10.9 0.2 2.1 2 0 0 2 2 2 0 FAM177 family DNA_pol3_a_NII PF11490.8 EKE38588.1 - 6.1 6.8 13.1 1.7 8.5 0.2 3.4 4 0 0 4 4 4 0 DNA polymerase III polC-type N-terminus II HU-CCDC81_euk_1 PF14908.6 EKE38590.1 - 0.026 14.7 0.4 0.065 13.4 0.4 1.8 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 SMC_Nse1 PF07574.13 EKE38591.1 - 2.1e-07 31.1 1.3 2.9e-07 30.6 1.1 1.3 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex Cut8 PF08559.10 EKE38591.1 - 0.00012 21.8 0.9 0.0002 21.1 0.9 1.5 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein zf-RING-like PF08746.11 EKE38591.1 - 0.00017 21.9 6.2 0.00028 21.1 6.2 1.4 1 0 0 1 1 1 1 RING-like domain zf-HC5HC2H PF13771.6 EKE38591.1 - 0.00051 20.2 2.7 0.0012 19.0 2.7 1.8 1 0 0 1 1 1 1 PHD-like zinc-binding domain Orthopox_F7 PF05813.12 EKE38591.1 - 0.0063 16.6 0.2 0.013 15.6 0.2 1.6 1 0 0 1 1 1 1 Orthopoxvirus F7 protein zf-HC5HC2H_2 PF13832.6 EKE38591.1 - 0.021 15.0 2.3 0.041 14.1 2.3 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain COG2 PF06148.11 EKE38591.1 - 0.081 13.0 1.8 0.17 12.0 1.2 2.0 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 CitX PF03802.14 EKE38591.1 - 0.12 12.1 0.0 0.12 12.1 0.0 1.9 3 0 0 3 3 3 0 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase zf-LITAF-like PF10601.9 EKE38591.1 - 2.6 8.4 8.9 10 6.4 6.7 2.5 2 1 0 2 2 2 0 LITAF-like zinc ribbon domain zf-RING_2 PF13639.6 EKE38591.1 - 3.3 8.1 9.6 6 7.3 9.6 1.4 1 0 0 1 1 1 0 Ring finger domain Pkinase PF00069.25 EKE38592.1 - 6.4e-63 212.6 1.0 5.4e-62 209.5 1.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38592.1 - 7.6e-27 94.2 0.7 3.1e-19 69.3 0.3 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 EKE38592.1 - 3.8e-05 24.3 2.3 8.3e-05 23.2 2.3 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 EKE38592.1 - 0.002 17.5 0.8 0.019 14.3 0.0 2.6 1 1 2 3 3 3 1 Kinase-like APH PF01636.23 EKE38592.1 - 0.0024 17.8 0.4 0.044 13.7 0.5 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EKE38592.1 - 0.003 16.6 3.1 0.003 16.6 3.1 1.9 2 1 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EKE38592.1 - 0.0032 16.9 0.3 0.0063 15.9 0.3 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EKE38592.1 - 0.0093 15.1 0.1 0.016 14.3 0.1 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 Phage_CRI PF05144.14 EKE38592.1 - 0.62 9.3 4.3 1.1 8.6 4.3 1.3 1 0 0 1 1 1 0 Phage replication protein CRI AAA_14 PF13173.6 EKE38593.1 - 0.012 15.6 0.5 0.032 14.3 0.1 1.9 2 1 0 2 2 2 0 AAA domain Yip1 PF04893.17 EKE38594.1 - 5.1e-07 29.6 25.7 1.3e-06 28.2 25.6 1.7 1 1 0 1 1 1 1 Yip1 domain DDDD PF10161.9 EKE38594.1 - 0.23 11.2 1.1 0.46 10.3 0.5 1.8 1 1 0 1 1 1 0 Putative mitochondrial precursor protein Lebercilin PF15619.6 EKE38595.1 - 0.0032 17.2 1.6 0.0034 17.1 1.6 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Cut12 PF11500.8 EKE38595.1 - 0.016 15.1 0.4 0.021 14.8 0.4 1.2 1 0 0 1 1 1 0 Spindle pole body formation-associated protein Aminotran_1_2 PF00155.21 EKE38595.1 - 0.062 12.5 0.1 0.074 12.2 0.1 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II DivIVA PF05103.13 EKE38595.1 - 0.088 12.9 5.0 0.11 12.6 3.3 1.8 1 1 1 2 2 2 0 DivIVA protein DUF572 PF04502.13 EKE38596.1 - 8.3e-56 190.0 26.8 9.8e-56 189.8 26.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF2396 PF09654.10 EKE38596.1 - 0.0082 16.3 0.3 0.011 15.8 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2396) zinc_ribbon_4 PF13717.6 EKE38596.1 - 0.013 15.4 2.0 2.5 8.1 0.3 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zf-ACC PF17848.1 EKE38596.1 - 0.078 13.1 2.2 5.3 7.2 0.3 2.8 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain TF_Zn_Ribbon PF08271.12 EKE38596.1 - 3 7.5 9.8 0.17 11.4 1.3 2.9 3 0 0 3 3 3 0 TFIIB zinc-binding Pkinase_Tyr PF07714.17 EKE38597.1 - 1.8e-48 165.1 0.0 2.7e-48 164.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38597.1 - 3.1e-47 161.1 0.0 5e-47 160.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE38597.1 - 9e-07 28.0 0.1 1.6e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE38597.1 - 0.057 12.8 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VSP PF03302.13 EKE38597.1 - 8.8 5.1 198.1 0.036 12.9 39.4 8.0 1 1 4 5 5 5 0 Giardia variant-specific surface protein DUF1242 PF06842.12 EKE38599.1 - 3.6e-13 49.1 0.9 5.8e-13 48.4 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) LGT PF01790.18 EKE38599.1 - 0.037 13.3 0.8 0.043 13.0 0.8 1.0 1 0 0 1 1 1 0 Prolipoprotein diacylglyceryl transferase NIF PF03031.18 EKE38601.1 - 7.8e-31 106.9 3.5 1e-30 106.6 3.5 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.6 EKE38601.1 - 6.5e-07 29.6 5.6 4.9e-06 26.7 0.2 2.2 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase DUF2608 PF11019.8 EKE38601.1 - 8.5e-05 22.2 5.8 0.26 10.7 0.8 3.1 1 1 1 3 3 3 2 Protein of unknown function (DUF2608) Acid_PPase PF12689.7 EKE38601.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 Acid Phosphatase PNK3P PF08645.11 EKE38601.1 - 0.037 13.7 0.8 0.067 12.9 0.7 1.5 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase Hydrolase PF00702.26 EKE38601.1 - 0.038 14.3 0.4 6.5 7.0 0.5 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase DnaJ_C PF01556.18 EKE38602.1 - 6.8e-43 146.3 0.2 1e-42 145.7 0.2 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EKE38602.1 - 2.7e-27 94.7 3.1 4.1e-27 94.1 3.1 1.3 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 EKE38602.1 - 0.0042 17.0 0.1 0.04 13.9 0.1 2.2 2 0 0 2 2 2 1 A repeated domain in UCH-protein Pkinase PF00069.25 EKE38603.1 - 1.1e-53 182.3 0.0 1.9e-53 181.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38603.1 - 5.1e-52 176.7 0.0 9.3e-52 175.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE38603.1 - 5.5e-07 28.7 0.0 1.2e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase MLANA PF14991.6 EKE38603.1 - 0.019 15.3 0.6 0.079 13.2 0.6 2.1 1 0 0 1 1 1 0 Protein melan-A Syndecan PF01034.20 EKE38603.1 - 0.027 14.4 0.2 0.068 13.1 0.2 1.7 1 0 0 1 1 1 0 Syndecan domain Stevor PF17410.2 EKE38603.1 - 0.065 12.8 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame PPV_E2_N PF00508.17 EKE38603.1 - 0.081 12.2 0.0 0.22 10.9 0.0 1.6 1 0 0 1 1 1 0 E2 (early) protein, N terminal APH PF01636.23 EKE38603.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family OppC_N PF12911.7 EKE38603.1 - 0.51 10.3 2.6 0.53 10.3 0.2 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Mid2 PF04478.12 EKE38603.1 - 0.8 9.5 9.1 0.1 12.4 4.3 2.0 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor SKG6 PF08693.10 EKE38603.1 - 2 7.9 7.4 4.7 6.7 7.4 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Peptidase_S41 PF03572.18 EKE38604.1 - 0.025 14.2 0.0 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 Peptidase family S41 PriX PF18689.1 EKE38604.1 - 0.35 11.2 8.8 0.097 13.0 2.7 2.9 2 0 0 2 2 2 0 Primase X RhoGEF PF00621.20 EKE38606.1 - 2.1e-28 99.8 1.0 2.1e-28 99.8 1.0 2.0 2 0 0 2 2 2 1 RhoGEF domain PhaP_Bmeg PF09602.10 EKE38606.1 - 0.012 15.5 2.2 0.028 14.4 1.6 2.0 1 1 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) PBECR5 PF18814.1 EKE38606.1 - 0.018 15.0 4.8 0.04 13.8 4.8 1.5 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 SF3A3 PF16837.5 EKE38606.1 - 0.13 12.7 0.2 0.13 12.7 0.2 2.3 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 RIFIN PF02009.16 EKE38607.1 - 2.4 8.0 5.3 0.18 11.7 0.3 1.6 2 0 0 2 2 2 0 Rifin RhoGAP PF00620.27 EKE38608.1 - 2.1e-22 79.6 0.8 2.1e-22 79.6 0.8 2.3 2 0 0 2 2 2 1 RhoGAP domain DUF2207 PF09972.9 EKE38609.1 - 0.046 12.5 0.0 0.067 11.9 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CDC48_N PF02359.18 EKE38610.1 - 6e-14 52.0 0.1 7.5e-13 48.5 0.1 2.0 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain CDC48_2 PF02933.17 EKE38610.1 - 0.00016 21.4 0.0 0.00039 20.1 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 UFD1 PF03152.14 EKE38610.1 - 0.0053 16.2 0.0 0.014 14.9 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 SH3_9 PF14604.6 EKE38610.1 - 0.15 11.9 0.0 1.2 9.0 0.0 2.3 3 0 0 3 3 3 0 Variant SH3 domain zf_C2H2_13 PF18508.1 EKE38611.1 - 0.13 11.9 0.3 1.2 8.8 0.1 2.2 2 0 0 2 2 2 0 Zinc finger domain Adaptin_N PF01602.20 EKE38612.1 - 6.5e-64 216.4 42.6 8.2e-64 216.0 42.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region RIX1 PF08167.12 EKE38612.1 - 0.00021 21.1 4.7 0.012 15.4 1.1 3.5 2 2 0 2 2 2 2 rRNA processing/ribosome biogenesis DUF2547 PF10818.8 EKE38612.1 - 0.0017 19.3 6.1 0.9 10.5 1.1 3.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2547) CNOT1_TTP_bind PF16417.5 EKE38613.1 - 3.9e-51 172.9 1.8 3.9e-51 172.9 1.8 3.6 3 0 0 3 3 3 2 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_CAF1_bind PF16415.5 EKE38613.1 - 8.3e-18 64.6 5.1 8.3e-18 64.6 5.1 4.2 4 2 1 5 5 5 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Not1 PF04054.15 EKE38613.1 - 1.5e-16 60.3 24.2 1.7e-13 50.3 7.9 3.8 1 1 2 3 3 3 2 CCR4-Not complex component, Not1 DUF3819 PF12842.7 EKE38613.1 - 2.5e-07 30.7 3.8 2.5e-07 30.7 3.8 3.5 4 0 0 4 4 4 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 EKE38613.1 - 0.00014 21.9 0.0 0.00014 21.9 0.0 4.3 5 0 0 5 5 5 1 CCR4-NOT transcription complex subunit 1 HEAT repeat MazG-like PF12643.7 EKE38613.1 - 0.74 10.1 4.7 1.1 9.6 0.5 3.5 3 0 0 3 3 3 0 MazG-like family UCH PF00443.29 EKE38614.1 - 1.8e-41 142.3 2.6 1.8e-41 142.3 2.6 3.2 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE38614.1 - 5.9e-10 39.2 0.9 5.9e-10 39.2 0.9 2.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF3861 PF12977.7 EKE38614.1 - 0.051 13.7 2.2 7 6.9 0.0 4.3 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) Peptidase_M99_m PF17130.4 EKE38616.1 - 0.095 12.6 0.1 0.19 11.7 0.1 1.6 1 0 0 1 1 1 0 beta-barrel domain of carboxypeptidase M99 Ras PF00071.22 EKE38617.1 - 3.7e-55 186.0 0.0 4.3e-55 185.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38617.1 - 3.2e-23 82.2 0.0 5.1e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38617.1 - 3.7e-09 36.3 0.0 4.7e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE38617.1 - 0.046 13.1 0.0 0.13 11.5 0.0 1.8 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Peptidase_A22B PF04258.13 EKE38618.1 - 1.3e-20 74.1 32.6 3.8e-20 72.6 32.6 1.7 1 1 0 1 1 1 1 Signal peptide peptidase Piwi PF02171.17 EKE38619.1 - 3.4e-16 59.4 1.3 9.1e-16 58.0 1.3 1.7 1 1 0 1 1 1 1 Piwi domain PAZ PF02170.22 EKE38619.1 - 0.00064 19.5 2.3 0.0019 18.0 1.9 2.1 2 0 0 2 2 2 1 PAZ domain RRS1 PF04939.12 EKE38619.1 - 0.27 11.1 1.3 0.52 10.2 1.3 1.4 1 0 0 1 1 1 0 Ribosome biogenesis regulatory protein (RRS1) DASH_Duo1 PF08651.10 EKE38620.1 - 0.03 14.1 3.4 0.11 12.3 1.7 2.6 1 1 1 2 2 2 0 DASH complex subunit Duo1 SpecificRecomb PF10136.9 EKE38620.1 - 0.15 10.3 0.1 0.25 9.6 0.1 1.3 1 0 0 1 1 1 0 Site-specific recombinase HAGH_C PF16123.5 EKE38620.1 - 0.69 10.5 5.3 15 6.2 0.8 2.6 2 0 0 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus NPV_P10 PF05531.12 EKE38620.1 - 4 8.0 7.1 7 7.2 1.0 3.3 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Sas6_CC PF18594.1 EKE38620.1 - 4.1 7.3 6.6 0.58 10.0 0.7 2.6 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain Tn7_Tnp_TnsA_C PF08721.11 EKE38622.1 - 0.014 16.0 0.2 0.21 12.2 0.0 2.8 3 0 0 3 3 3 0 TnsA endonuclease C terminal Propeptide_C1 PF08127.13 EKE38622.1 - 0.042 13.7 0.0 0.095 12.6 0.0 1.6 1 0 0 1 1 1 0 Peptidase family C1 propeptide DSBA PF01323.20 EKE38622.1 - 0.097 12.4 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 DSBA-like thioredoxin domain RhoGEF PF00621.20 EKE38623.1 - 2.5e-10 40.9 3.2 2.5e-10 40.9 3.2 3.0 2 1 0 2 2 2 1 RhoGEF domain DUF406 PF04175.12 EKE38623.1 - 0.044 14.3 1.9 0.19 12.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF406) Rhodanese PF00581.20 EKE38624.1 - 9.8e-10 38.9 0.0 1.7e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain LBP_C PF17386.2 EKE38624.1 - 0.07 13.0 2.3 0.31 11.0 0.1 2.3 2 0 0 2 2 2 0 Lacto-N-biose phosphorylase C-terminal domain DUF1681 PF07933.14 EKE38625.1 - 4.5e-50 169.2 0.0 5.7e-50 168.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) MMR_HSR1 PF01926.23 EKE38626.1 - 5.8e-11 42.5 1.6 7.9e-11 42.1 0.1 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE38626.1 - 2e-09 37.6 1.9 2.2e-06 27.7 0.0 3.2 3 0 0 3 3 3 2 RsgA GTPase Septin PF00735.18 EKE38626.1 - 1.9e-08 34.0 2.2 0.00094 18.5 0.0 2.7 3 0 0 3 3 3 2 Septin AAA_16 PF13191.6 EKE38626.1 - 5.2e-05 23.7 0.1 0.00016 22.1 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 EKE38626.1 - 6.9e-05 23.4 0.1 0.00044 20.8 0.0 2.3 2 0 0 2 2 2 1 ABC transporter FeoB_N PF02421.18 EKE38626.1 - 0.00028 20.4 0.2 0.0012 18.4 0.2 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_23 PF13476.6 EKE38626.1 - 0.00034 21.2 6.9 0.0041 17.6 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EKE38626.1 - 0.0013 18.2 0.0 0.0041 16.6 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region Arf PF00025.21 EKE38626.1 - 0.0016 18.0 0.2 0.015 14.8 0.2 2.4 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EKE38626.1 - 0.0026 18.0 0.4 0.018 15.2 0.2 2.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EKE38626.1 - 0.0026 17.4 1.6 0.041 13.5 0.6 3.0 2 1 0 2 2 2 1 Ras family DUF815 PF05673.13 EKE38626.1 - 0.0027 16.9 0.0 0.0084 15.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) G-alpha PF00503.20 EKE38626.1 - 0.0034 16.6 3.0 0.28 10.3 0.1 2.8 2 1 0 3 3 3 1 G-protein alpha subunit RNA_helicase PF00910.22 EKE38626.1 - 0.0055 17.1 0.1 0.19 12.1 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 EKE38626.1 - 0.0058 16.9 0.0 0.015 15.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain IIGP PF05049.13 EKE38626.1 - 0.0058 15.7 1.8 0.046 12.8 0.0 2.5 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.6 EKE38626.1 - 0.0063 16.2 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AIG1 PF04548.16 EKE38626.1 - 0.01 15.2 3.1 0.015 14.6 0.1 2.5 3 0 0 3 3 3 0 AIG1 family zf-TFIIB PF13453.6 EKE38626.1 - 0.025 13.9 0.5 0.085 12.2 0.5 2.0 1 0 0 1 1 1 0 Transcription factor zinc-finger Gtr1_RagA PF04670.12 EKE38626.1 - 0.028 13.8 0.2 0.028 13.8 0.2 2.5 3 1 0 3 3 3 0 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 EKE38626.1 - 0.047 13.7 2.8 0.11 12.5 0.3 2.7 3 1 0 4 4 3 0 Dynamin family Sigma54_activat PF00158.26 EKE38626.1 - 0.083 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_19 PF13245.6 EKE38626.1 - 0.1 12.9 0.1 0.28 11.5 0.0 1.7 2 0 0 2 2 1 0 AAA domain DUF87 PF01935.17 EKE38626.1 - 0.62 10.1 5.3 0.44 10.6 0.2 2.7 2 1 1 3 3 3 0 Helicase HerA, central domain Zn_Tnp_IS1595 PF12760.7 EKE38626.1 - 5.1 7.2 9.0 1.3 9.0 4.4 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Pkinase PF00069.25 EKE38627.1 - 6e-24 84.8 0.4 9.4e-24 84.2 0.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38627.1 - 7.1e-22 77.9 0.1 1e-21 77.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TLD PF07534.16 EKE38627.1 - 0.028 14.6 0.1 0.062 13.5 0.1 1.6 1 0 0 1 1 1 0 TLD Noc2 PF03715.13 EKE38628.1 - 5.5e-44 150.6 10.7 7.6e-44 150.1 10.7 1.2 1 0 0 1 1 1 1 Noc2p family Nop14 PF04147.12 EKE38628.1 - 3.2e-05 22.4 0.4 3.2e-05 22.4 0.4 2.2 2 0 0 2 2 2 1 Nop14-like family ATPase PF06745.13 EKE38628.1 - 0.37 10.1 4.9 0.81 9.0 2.3 2.2 2 0 0 2 2 2 0 KaiC PrmA PF06325.13 EKE38629.1 - 1.2e-12 47.8 0.0 1.7e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 EKE38629.1 - 2.5e-09 37.6 0.0 8.3e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE38629.1 - 2.8e-09 37.5 0.0 6e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EKE38629.1 - 5.8e-09 35.9 0.0 1.4e-08 34.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKE38629.1 - 2.3e-06 27.6 0.0 4.7e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.16 EKE38629.1 - 3.4e-06 27.0 0.2 6.7e-06 26.0 0.1 1.5 1 1 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 EKE38629.1 - 3.7e-06 26.6 0.0 6.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EKE38629.1 - 5e-06 26.5 0.1 7.6e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain PRMT5_C PF17286.2 EKE38629.1 - 0.00012 22.0 0.0 0.00024 21.1 0.0 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain TehB PF03848.14 EKE38629.1 - 0.00022 20.7 0.7 0.00051 19.5 0.7 1.7 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 EKE38629.1 - 0.00026 21.7 0.0 0.00057 20.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EKE38629.1 - 0.00036 19.9 0.1 0.00048 19.5 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PRMT5 PF05185.16 EKE38629.1 - 0.00045 20.1 0.1 0.00066 19.6 0.1 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase FtsJ PF01728.19 EKE38629.1 - 0.00081 19.5 0.0 0.0016 18.6 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_24 PF13578.6 EKE38629.1 - 0.00087 20.3 0.0 0.0015 19.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EKE38629.1 - 0.012 14.5 0.0 0.016 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Cons_hypoth95 PF03602.15 EKE38629.1 - 0.019 14.6 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_16 PF10294.9 EKE38629.1 - 0.021 14.6 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_32 PF13679.6 EKE38629.1 - 0.021 14.8 0.1 0.037 14.0 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain Rep_fac-A_C PF08646.10 EKE38631.1 - 2.2e-31 108.6 3.0 2.2e-31 108.6 3.0 2.1 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EKE38631.1 - 2.4e-09 37.0 1.5 1.1e-07 31.7 0.2 3.4 3 0 0 3 3 3 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 EKE38631.1 - 1.6e-08 34.4 9.1 1.2e-05 25.2 0.2 4.4 4 0 0 4 4 4 1 OB-fold nucleic acid binding domain DZR PF12773.7 EKE38631.1 - 0.00059 19.8 0.2 0.0012 18.8 0.2 1.5 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 EKE38631.1 - 0.0033 17.1 5.1 0.0079 15.9 5.1 1.7 1 0 0 1 1 1 1 zinc-ribbon domain CDC24_OB3 PF17244.2 EKE38631.1 - 0.013 15.3 5.8 0.013 15.2 0.9 2.9 3 1 0 3 3 3 0 Cell division control protein 24, OB domain 3 zf-ribbon_3 PF13248.6 EKE38631.1 - 0.013 14.9 1.8 0.023 14.1 1.8 1.4 1 0 0 1 1 1 0 zinc-ribbon domain RecJ_OB PF17768.1 EKE38631.1 - 0.04 14.2 3.7 28 5.0 0.1 3.8 4 0 0 4 4 4 0 RecJ OB domain TFA2_Winged_2 PF18121.1 EKE38631.1 - 0.054 13.2 0.0 7.3 6.4 0.0 3.0 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 Med10 PF09748.9 EKE38631.1 - 0.11 12.5 0.4 0.3 11.0 0.4 1.7 1 0 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex zinc_ribbon_15 PF17032.5 EKE38631.1 - 0.19 12.5 4.7 0.21 12.4 3.0 2.0 2 0 0 2 2 1 0 zinc-ribbon family zf-C6H2 PF15801.5 EKE38631.1 - 0.32 11.3 4.2 0.71 10.2 4.2 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding tRNA-synt_1d PF00750.19 EKE38632.1 - 0.0014 17.6 2.2 0.0017 17.4 0.9 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (R) LRR_5 PF13306.6 EKE38633.1 - 2.5e-44 150.3 18.9 6.9e-26 90.7 7.2 3.0 2 2 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE38633.1 - 2.9e-07 30.2 0.1 0.11 12.2 0.0 4.1 3 0 0 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 EKE38635.1 - 2.2 9.1 8.8 1.3e+02 3.8 0.1 5.0 4 1 0 4 4 4 0 Leucine Rich Repeat LSM PF01423.22 EKE38638.1 - 0.009 15.7 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 LSM domain TMEM208_SND2 PF05620.11 EKE38639.1 - 3.6e-30 105.0 3.1 3.9e-30 104.8 3.1 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 7tm_1 PF00001.21 EKE38639.1 - 0.031 13.6 1.4 0.057 12.7 0.1 1.7 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF2981 PF11200.8 EKE38639.1 - 2.9 7.5 7.0 0.63 9.7 2.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2981) Lactamase_B PF00753.27 EKE38640.1 - 3.4e-24 85.9 0.1 4e-24 85.7 0.1 1.0 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EKE38640.1 - 0.0011 18.5 0.0 0.0015 18.0 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RNase_T PF00929.24 EKE38641.1 - 0.14 12.7 0.1 0.14 12.7 0.1 3.7 4 2 0 4 4 4 0 Exonuclease TRAPPC-Trs85 PF12739.7 EKE38642.1 - 1.4e-09 37.5 0.0 2.4e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_11 PF13414.6 EKE38642.1 - 0.00013 21.6 0.3 0.00026 20.6 0.3 1.5 1 0 0 1 1 1 1 TPR repeat TPR_8 PF13181.6 EKE38642.1 - 0.00017 21.5 0.2 0.00052 20.0 0.2 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EKE38642.1 - 0.003 17.3 0.1 0.0074 16.1 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 EKE38642.1 - 0.0086 16.1 0.1 0.023 14.8 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 EKE38642.1 - 0.027 14.5 0.0 0.068 13.2 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat RPN7 PF10602.9 EKE38642.1 - 0.061 13.0 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 26S proteasome subunit RPN7 DUF2645 PF10840.8 EKE38642.1 - 0.2 12.3 2.2 8.5 7.1 0.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2645) AMP-binding PF00501.28 EKE38644.1 - 9.2e-74 248.5 0.0 1.1e-73 248.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EKE38644.1 - 0.019 15.9 0.0 0.045 14.7 0.0 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Solute_trans_a PF03619.16 EKE38645.1 - 1.2e-33 116.8 25.2 1.4e-33 116.5 25.2 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha HAD_2 PF13419.6 EKE38646.1 - 1.6e-12 47.9 0.1 4.1e-12 46.5 0.0 1.6 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKE38646.1 - 1.9e-05 25.0 0.0 3.9e-05 24.0 0.0 1.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EKE38646.1 - 0.0084 16.2 0.1 0.017 15.2 0.0 1.5 2 0 0 2 2 2 1 HAD-hyrolase-like Crp PF00325.20 EKE38646.1 - 0.16 11.7 0.7 1.9 8.2 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family Mito_carr PF00153.27 EKE38647.1 - 0.0002 21.2 0.6 0.00049 20.0 0.3 1.8 2 0 0 2 2 2 1 Mitochondrial carrier protein PIP5K PF01504.18 EKE38648.1 - 1.2e-72 244.5 27.2 2.2e-68 230.4 27.2 3.2 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase GREB1 PF15782.5 EKE38648.1 - 0.00045 17.5 22.9 0.00059 17.1 22.9 1.0 1 0 0 1 1 1 1 Gene regulated by oestrogen in breast cancer LETM1 PF07766.13 EKE38648.1 - 0.055 12.8 0.0 0.055 12.8 0.0 2.7 2 1 0 2 2 2 0 LETM1-like protein Macoilin PF09726.9 EKE38648.1 - 0.11 11.0 21.5 0.15 10.6 21.5 1.1 1 0 0 1 1 1 0 Macoilin family BSP_II PF05432.11 EKE38648.1 - 0.19 11.4 28.0 0.29 10.8 28.0 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4718 PF15842.5 EKE38648.1 - 0.42 10.4 14.0 0.74 9.6 14.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) Ndc1_Nup PF09531.10 EKE38648.1 - 0.7 8.5 10.7 0.99 8.0 10.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDC45 PF02724.14 EKE38648.1 - 6.1 5.0 21.4 9.5 4.4 21.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Lactamase_B_2 PF12706.7 EKE38649.1 - 1.3e-14 54.2 0.6 1.7e-14 53.8 0.6 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EKE38649.1 - 4.3e-13 49.7 3.2 6.3e-13 49.2 3.2 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 EKE38649.1 - 0.01 15.5 0.0 0.025 14.2 0.0 1.6 1 0 0 1 1 1 0 tRNase Z endonuclease DUF5026 PF16429.5 EKE38649.1 - 0.093 12.8 0.1 8 6.6 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5026) PDEase_II PF02112.15 EKE38649.1 - 0.11 11.6 9.3 23 3.9 9.2 2.5 1 1 0 1 1 1 0 cAMP phosphodiesterases class-II zf-RING_2 PF13639.6 EKE38650.1 - 3e-11 43.5 16.1 5.7e-11 42.6 16.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EKE38650.1 - 4.7e-09 35.8 9.0 1.8e-08 34.0 9.0 2.1 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EKE38650.1 - 7.8e-07 29.3 12.5 1.8e-06 28.2 12.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EKE38650.1 - 2e-06 27.5 15.4 4.7e-06 26.3 15.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE38650.1 - 1.8e-05 24.5 16.0 3.6e-05 23.5 16.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE38650.1 - 7.8e-05 22.6 11.8 0.00032 20.7 9.5 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EKE38650.1 - 0.00031 20.7 6.2 0.0005 20.1 6.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EKE38650.1 - 0.00034 20.5 12.9 0.00066 19.6 12.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EKE38650.1 - 0.0034 17.2 12.5 0.0075 16.1 12.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn-C2H2_12 PF18112.1 EKE38650.1 - 0.011 16.2 6.5 0.83 10.2 0.5 2.7 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Rad50_zn_hook PF04423.14 EKE38650.1 - 0.08 12.8 1.2 1.1 9.1 0.1 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif Prok-RING_4 PF14447.6 EKE38650.1 - 0.59 10.0 16.8 4.4 7.2 10.8 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 UQ_con PF00179.26 EKE38651.1 - 1.1e-43 148.3 0.2 1.2e-43 148.1 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKE38651.1 - 0.00017 21.3 0.0 0.00019 21.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EKE38651.1 - 0.00029 21.1 0.1 0.00037 20.8 0.1 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 EKE38651.1 - 0.043 13.7 0.3 0.071 13.0 0.3 1.4 1 1 0 1 1 1 0 UEV domain Ras PF00071.22 EKE38653.1 - 1.5e-39 135.2 0.0 1.8e-39 135.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38653.1 - 2.4e-26 92.3 0.0 3.3e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38653.1 - 2.2e-13 50.1 0.0 2.6e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE38653.1 - 5.5e-05 22.6 0.0 7.5e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EKE38653.1 - 0.0011 18.7 0.0 0.029 14.1 0.0 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EKE38653.1 - 0.0036 17.4 0.0 0.0055 16.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE38653.1 - 0.0098 15.3 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 EKE38653.1 - 0.033 14.2 0.1 0.088 12.8 0.1 1.7 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 EKE38653.1 - 0.077 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase G-alpha PF00503.20 EKE38653.1 - 0.078 12.1 0.1 7.7 5.6 0.0 2.4 1 1 1 2 2 2 0 G-protein alpha subunit GTP_EFTU PF00009.27 EKE38653.1 - 0.08 12.5 0.1 0.24 10.9 0.0 1.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 EKE38653.1 - 0.084 12.6 0.0 2.7 7.7 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 EKE38653.1 - 0.094 12.2 0.1 0.31 10.5 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 EKE38653.1 - 0.1 12.1 0.0 2.3 7.8 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Mito_fiss_Elm1 PF06258.11 EKE38653.1 - 0.17 11.0 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial fission ELM1 RasGEF PF00617.19 EKE38654.1 - 1.7e-09 38.1 4.3 1.7e-09 38.1 4.3 1.8 2 0 0 2 2 2 1 RasGEF domain DUF4211 PF13926.6 EKE38654.1 - 0.0091 16.1 0.9 0.027 14.5 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) TAFH PF07531.14 EKE38654.1 - 0.015 15.4 1.7 0.067 13.3 0.1 2.7 3 0 0 3 3 3 0 NHR1 homology to TAF CCDC74_C PF14917.6 EKE38654.1 - 0.034 14.6 0.1 0.092 13.3 0.1 1.8 1 0 0 1 1 1 0 Coiled coil protein 74, C terminal C6_DPF PF10170.9 EKE38655.1 - 0.11 12.9 0.0 0.3 11.5 0.0 1.7 1 1 0 1 1 1 0 Cysteine-rich domain VPS9 PF02204.18 EKE38656.1 - 2e-09 37.6 0.4 1.5e-08 34.8 0.0 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Arf PF00025.21 EKE38656.1 - 2.4e-08 33.7 0.0 2.2e-06 27.2 0.0 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 EKE38656.1 - 0.0009 19.5 0.1 0.13 12.5 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EKE38656.1 - 0.001 19.5 0.0 0.009 16.4 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 EKE38656.1 - 0.0016 18.7 0.4 0.0055 17.0 0.2 2.0 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EKE38656.1 - 0.013 14.7 1.6 0.017 14.3 0.1 1.9 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.12 EKE38656.1 - 0.025 14.5 0.1 0.064 13.2 0.1 1.7 1 0 0 1 1 1 0 NACHT domain Septin PF00735.18 EKE38656.1 - 0.027 13.8 0.1 0.027 13.8 0.1 2.5 3 0 0 3 3 3 0 Septin RsgA_GTPase PF03193.16 EKE38656.1 - 0.038 13.9 6.1 0.094 12.6 0.0 3.3 3 0 0 3 3 3 0 RsgA GTPase AAA PF00004.29 EKE38656.1 - 0.039 14.4 0.8 0.83 10.1 0.0 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EKE38656.1 - 0.055 13.7 0.2 0.18 12.0 0.2 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EKE38656.1 - 0.076 13.6 2.4 1.2 9.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EKE38656.1 - 0.17 12.0 0.0 0.53 10.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EKE38656.1 - 0.22 12.0 0.0 0.22 12.0 0.0 2.4 2 1 0 2 2 1 0 ABC transporter PduV-EutP PF10662.9 EKE38656.1 - 0.32 10.7 3.5 0.21 11.3 0.2 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 EKE38656.1 - 0.94 9.3 0.0 0.94 9.3 0.0 3.8 5 0 0 5 5 5 0 ATPase domain predominantly from Archaea DUF948 PF06103.11 EKE38656.1 - 7.8 6.8 6.4 1.9 8.8 0.1 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Rap1_C PF11626.8 EKE38657.1 - 1.1e-07 31.9 0.0 1.6e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain PI_PP_C PF18365.1 EKE38657.1 - 0.096 12.7 0.0 3.2 7.7 0.0 2.1 2 0 0 2 2 2 0 Phosphoinositide phosphatase C-terminal domain UBA PF00627.31 EKE38657.1 - 0.097 12.6 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain Avl9 PF09794.9 EKE38658.1 - 4.9e-21 74.8 3.0 1.3e-12 47.2 0.5 2.1 1 1 1 2 2 2 2 Transport protein Avl9 SPA PF08616.10 EKE38658.1 - 0.0019 18.1 0.9 0.032 14.2 0.9 2.5 1 1 0 1 1 1 1 Stabilization of polarity axis RabGAP-TBC PF00566.18 EKE38659.1 - 7.7e-38 130.3 4.0 7.7e-38 130.3 4.0 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain IL34 PF15036.6 EKE38659.1 - 0.0018 18.3 0.1 0.34 10.9 0.0 2.3 1 1 1 2 2 2 2 Interleukin 34 IDO PF01231.18 EKE38659.1 - 0.04 12.7 0.3 0.12 11.1 0.3 1.8 1 1 0 1 1 1 0 Indoleamine 2,3-dioxygenase ADP_PFK_GK PF04587.15 EKE38659.1 - 0.068 11.7 0.0 0.14 10.7 0.0 1.5 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region Baculo_PEP_C PF04513.12 EKE38659.1 - 0.21 11.6 0.5 1.2 9.2 0.1 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2971 PF11185.8 EKE38659.1 - 1.2 10.4 6.2 2.2 9.5 1.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2971) PX PF00787.24 EKE38660.1 - 5.8e-10 39.2 0.1 1.1e-09 38.2 0.1 1.5 1 0 0 1 1 1 1 PX domain GATase_7 PF13537.6 EKE38661.1 - 0.0045 16.9 0.1 0.0062 16.5 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF1947 PF09183.10 EKE38661.1 - 0.041 14.2 0.6 2.5 8.5 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1947) HP0268 PF18618.1 EKE38661.1 - 0.066 13.6 2.8 0.085 13.3 2.2 1.5 1 1 0 1 1 1 0 HP0268 Cnn_1N PF07989.11 EKE38661.1 - 0.56 10.4 5.9 1.3 9.2 0.5 2.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 cEGF PF12662.7 EKE38662.1 - 2.2 8.3 41.5 0.59 10.1 1.8 6.3 6 0 0 6 6 6 0 Complement Clr-like EGF-like AIG1 PF04548.16 EKE38664.1 - 1.8e-11 43.8 0.3 1.9e-11 43.7 0.3 1.0 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 EKE38664.1 - 8.4e-07 29.1 0.2 8.9e-07 29.0 0.2 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE38664.1 - 0.00058 19.8 0.9 0.0013 18.7 0.9 1.5 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 EKE38664.1 - 0.0027 17.8 1.8 0.37 10.8 0.1 2.1 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 EKE38664.1 - 0.01 15.4 0.3 1.8 8.1 0.1 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EKE38664.1 - 0.035 13.7 0.2 0.039 13.5 0.2 1.0 1 0 0 1 1 1 0 Ferrous iron transport protein B SRPRB PF09439.10 EKE38664.1 - 0.11 11.9 0.1 0.12 11.8 0.1 1.0 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA PF00004.29 EKE38664.1 - 0.13 12.7 0.0 0.13 12.6 0.0 1.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AIG1 PF04548.16 EKE38665.1 - 1.7e-18 66.7 0.1 2.8e-18 66.0 0.1 1.3 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 EKE38665.1 - 3.9e-09 36.6 0.1 9.4e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EKE38665.1 - 4.6e-05 22.8 0.5 0.00011 21.6 0.5 1.6 1 0 0 1 1 1 1 Septin RsgA_GTPase PF03193.16 EKE38665.1 - 0.00023 21.1 1.1 0.00072 19.5 1.1 1.8 1 0 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 EKE38665.1 - 0.00041 20.4 7.2 0.25 11.4 1.5 2.9 3 0 0 3 3 3 2 Dynamin family AAA_22 PF13401.6 EKE38665.1 - 0.0062 16.8 0.1 0.016 15.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EKE38665.1 - 0.048 13.2 0.4 0.086 12.4 0.4 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B Ras PF00071.22 EKE38665.1 - 0.12 12.0 6.6 0.083 12.5 0.7 3.0 3 1 0 3 3 3 0 Ras family ABC_tran PF00005.27 EKE38665.1 - 0.37 11.3 4.5 0.14 12.7 1.1 2.0 2 1 0 2 2 2 0 ABC transporter Roc PF08477.13 EKE38665.1 - 0.77 10.0 4.9 0.27 11.4 0.4 2.6 2 2 1 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase TMEM164 PF14808.6 EKE38666.1 - 1.1e-17 64.3 20.1 1.6e-17 63.8 20.1 1.2 1 0 0 1 1 1 1 TMEM164 family Pmp3 PF01679.17 EKE38667.1 - 5.7e-09 36.0 11.7 6.3e-09 35.9 11.7 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF4131 PF13567.6 EKE38667.1 - 0.24 11.1 2.4 0.26 10.9 2.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) JMY PF15871.5 EKE38669.1 - 0.011 15.1 1.8 0.011 15.1 1.8 1.9 2 0 0 2 2 2 0 Junction-mediating and -regulatory protein DUF4065 PF13274.6 EKE38669.1 - 1.5 9.8 10.0 1.3 9.9 3.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4065) DUF5339 PF17274.2 EKE38669.1 - 4.1 8.3 11.3 3.3 8.6 5.8 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5339) Ras PF00071.22 EKE38670.1 - 4e-31 107.8 0.0 5e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38670.1 - 7e-12 45.6 0.0 1.4e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EKE38670.1 - 0.0014 18.3 0.1 0.079 12.7 0.0 2.3 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EKE38670.1 - 0.0041 17.2 0.0 0.0086 16.2 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EKE38670.1 - 0.011 15.2 0.0 0.023 14.1 0.0 1.6 1 1 0 1 1 1 0 ADP-ribosylation factor family SRPRB PF09439.10 EKE38670.1 - 0.015 14.7 0.0 0.037 13.5 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EKE38670.1 - 0.036 14.1 0.2 0.2 11.7 0.1 2.2 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 EKE38670.1 - 0.043 13.2 0.0 0.41 10.0 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein DUF3721 PF12518.8 EKE38670.1 - 0.055 13.3 0.4 0.1 12.4 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function FeoB_N PF02421.18 EKE38670.1 - 0.088 12.3 0.0 2.4 7.7 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B Guanylate_kin PF00625.21 EKE38671.1 - 1.3e-54 184.7 1.0 1.4e-54 184.5 1.0 1.0 1 0 0 1 1 1 1 Guanylate kinase ABC_tran PF00005.27 EKE38671.1 - 1.1e-05 25.9 0.0 1.7e-05 25.4 0.0 1.5 1 1 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 EKE38671.1 - 4.6e-05 24.0 0.2 0.00014 22.4 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EKE38671.1 - 0.00022 21.4 0.3 0.0023 18.1 0.3 2.2 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EKE38671.1 - 0.00032 20.7 0.2 0.00043 20.3 0.2 1.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EKE38671.1 - 0.00037 20.8 0.0 0.00067 20.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.6 EKE38671.1 - 0.00073 19.8 0.0 0.0015 18.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EKE38671.1 - 0.00082 19.3 0.1 0.0019 18.1 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 EKE38671.1 - 0.0016 18.5 0.1 0.0049 16.9 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EKE38671.1 - 0.0029 18.0 0.0 0.0032 17.9 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EKE38671.1 - 0.0034 17.8 0.5 0.049 14.1 0.1 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 EKE38671.1 - 0.0038 17.7 1.1 0.021 15.2 0.5 2.4 1 1 1 2 2 2 1 AAA domain AAA_7 PF12775.7 EKE38671.1 - 0.0043 16.6 0.1 0.028 13.9 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region CoaE PF01121.20 EKE38671.1 - 0.0063 16.2 0.6 0.032 13.9 0.7 1.9 2 0 0 2 2 2 1 Dephospho-CoA kinase Rad17 PF03215.15 EKE38671.1 - 0.0079 16.1 0.0 0.012 15.6 0.0 1.4 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_29 PF13555.6 EKE38671.1 - 0.012 15.4 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 EKE38671.1 - 0.017 15.0 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 NTPase AAA_28 PF13521.6 EKE38671.1 - 0.024 14.9 0.4 0.31 11.3 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA_23 PF13476.6 EKE38671.1 - 0.027 15.0 2.0 0.1 13.1 2.0 2.1 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 EKE38671.1 - 0.028 14.4 0.1 0.048 13.7 0.1 1.5 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EKE38671.1 - 0.032 14.3 0.0 0.062 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EKE38671.1 - 0.032 14.0 0.0 0.058 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EKE38671.1 - 0.034 13.9 0.2 0.1 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain Roc PF08477.13 EKE38671.1 - 0.043 14.0 0.1 0.15 12.3 0.0 2.0 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 EKE38671.1 - 0.061 12.9 0.1 0.23 11.1 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EKE38671.1 - 0.066 13.2 0.1 0.18 11.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EKE38671.1 - 0.07 13.0 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain KTI12 PF08433.10 EKE38671.1 - 0.092 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Methyltransf_12 PF08242.12 EKE38671.1 - 0.16 12.7 0.0 1.1 10.0 0.0 2.2 1 1 0 2 2 2 0 Methyltransferase domain AAA PF00004.29 EKE38672.1 - 1e-40 139.2 0.0 2.2e-40 138.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EKE38672.1 - 1.7e-25 88.7 0.0 6.2e-25 87.0 0.1 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EKE38672.1 - 1.3e-16 60.4 6.3 1.3e-16 60.4 6.3 2.1 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TIP49 PF06068.13 EKE38672.1 - 4.7e-06 26.1 0.4 0.00028 20.2 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 EKE38672.1 - 4.3e-05 23.3 0.0 7.7e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EKE38672.1 - 5.7e-05 23.4 0.0 0.0057 16.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EKE38672.1 - 9.4e-05 22.2 0.0 0.00019 21.2 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 EKE38672.1 - 0.00047 20.3 0.0 0.0012 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 EKE38672.1 - 0.00048 19.4 0.0 0.00083 18.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EKE38672.1 - 0.00056 20.3 0.0 0.0093 16.4 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_lid_3 PF17862.1 EKE38672.1 - 0.00064 19.5 0.0 0.0019 18.0 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EKE38672.1 - 0.0014 18.6 0.0 0.0088 16.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EKE38672.1 - 0.0024 18.3 0.0 0.0062 16.9 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 EKE38672.1 - 0.0034 17.4 0.0 0.009 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EKE38672.1 - 0.0041 17.3 0.0 0.0096 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EKE38672.1 - 0.0051 17.4 0.4 0.029 14.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain DUF5113 PF17140.4 EKE38672.1 - 0.0097 15.7 0.2 0.024 14.5 0.2 1.7 2 1 0 2 2 1 1 Domain of unknown function (DUF5113) AAA_17 PF13207.6 EKE38672.1 - 0.011 16.2 1.0 0.038 14.4 0.0 2.3 2 1 1 3 3 3 0 AAA domain AAA_24 PF13479.6 EKE38672.1 - 0.019 14.7 0.0 0.05 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKE38672.1 - 0.021 14.3 0.0 0.066 12.7 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EKE38672.1 - 0.023 14.1 0.1 0.067 12.6 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EKE38672.1 - 0.039 13.5 0.1 0.26 10.8 0.1 2.1 2 0 0 2 2 2 0 AAA domain TPR_1 PF00515.28 EKE38672.1 - 0.051 13.4 0.7 0.051 13.4 0.7 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Sigma54_activat PF00158.26 EKE38672.1 - 0.074 12.7 0.0 0.5 10.0 0.0 2.3 2 1 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EKE38672.1 - 0.088 12.9 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.16 EKE38672.1 - 0.1 12.1 0.0 0.26 10.7 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein TPR_2 PF07719.17 EKE38672.1 - 0.29 11.4 4.4 0.63 10.3 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EKE38672.1 - 2.6 8.5 9.2 0.28 11.5 1.3 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat STT3 PF02516.14 EKE38674.1 - 1.4e-114 383.8 44.6 5.8e-114 381.7 44.6 1.7 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.6 EKE38674.1 - 0.00015 22.1 15.9 0.00015 22.1 15.9 3.7 4 0 0 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MCM PF00493.23 EKE38675.1 - 1.4e-99 331.7 0.0 2.1e-99 331.2 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EKE38675.1 - 4.9e-34 116.9 0.2 9.6e-34 115.9 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EKE38675.1 - 2.2e-24 85.7 0.6 5.4e-24 84.4 0.6 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EKE38675.1 - 2.5e-12 47.3 1.5 8.4e-12 45.6 1.5 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EKE38675.1 - 3.1e-08 33.3 0.0 3.2e-06 26.7 0.0 2.5 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EKE38675.1 - 0.0011 18.8 0.0 0.0037 17.1 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EKE38675.1 - 0.0062 16.5 0.0 0.025 14.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EKE38675.1 - 0.01 15.6 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Methyltransf_20 PF12147.8 EKE38675.1 - 0.15 11.2 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Transp_cyt_pur PF02133.15 EKE38675.1 - 0.25 10.1 0.0 0.38 9.5 0.0 1.2 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin Methyltr_RsmB-F PF01189.17 EKE38676.1 - 3.1e-38 131.4 0.4 1.8e-37 128.9 0.0 2.1 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EKE38676.1 - 0.00045 20.4 0.1 0.0014 18.7 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_15 PF09445.10 EKE38676.1 - 0.0032 17.1 1.7 0.0036 16.9 0.1 1.9 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase Top6b_C PF18000.1 EKE38676.1 - 0.058 13.6 2.5 0.19 11.9 0.1 2.7 3 0 0 3 3 3 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain Rep-A_N PF04057.12 EKE38676.1 - 0.74 9.9 4.8 6.7 6.8 0.0 2.7 2 1 1 3 3 3 0 Replication factor-A protein 1, N-terminal domain TPR_8 PF13181.6 EKE38677.1 - 3e-05 23.9 0.5 0.00012 22.0 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EKE38677.1 - 7.6e-05 22.5 0.1 0.00033 20.5 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EKE38677.1 - 0.0033 17.2 0.3 0.0086 15.9 0.3 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 EKE38677.1 - 0.009 16.6 0.0 8.6 7.2 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF4919 PF16266.5 EKE38677.1 - 0.013 15.4 0.1 0.03 14.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4919) TPR_7 PF13176.6 EKE38677.1 - 0.1 12.7 0.3 0.79 9.9 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Fibrillarin PF01269.17 EKE38678.1 - 3.3e-99 330.6 0.0 3.9e-99 330.4 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EKE38678.1 - 0.0091 15.7 0.0 0.023 14.4 0.0 1.6 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EKE38678.1 - 0.03 14.1 0.1 0.05 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Phospholip_B PF04916.13 EKE38680.1 - 1.1e-123 413.6 15.3 1.3e-123 413.4 15.3 1.0 1 0 0 1 1 1 1 Phospholipase B Pkinase_Tyr PF07714.17 EKE38681.1 - 6.6e-48 163.2 0.0 1e-47 162.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38681.1 - 9e-38 130.1 0.0 1.4e-37 129.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Staphopain_pro PF14731.6 EKE38681.1 - 0.027 14.5 0.6 0.07 13.1 0.6 1.7 1 0 0 1 1 1 0 Staphopain proregion EphA2_TM PF14575.6 EKE38681.1 - 0.15 13.0 0.8 3.2 8.7 0.2 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 EKE38681.1 - 0.65 10.0 7.5 0.052 13.5 2.1 1.9 2 0 0 2 2 2 0 Syndecan domain Beta-TrCP_D PF12125.8 EKE38681.1 - 0.86 9.5 3.2 0.34 10.8 0.3 1.9 2 0 0 2 2 2 0 D domain of beta-TrCP DSPc PF00782.20 EKE38684.1 - 1.5e-29 102.5 4.2 1.8e-29 102.3 0.1 2.8 2 2 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EKE38684.1 - 0.0064 16.1 0.4 0.012 15.2 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EKE38684.1 - 0.0075 16.4 8.9 0.089 12.9 8.0 2.4 1 1 0 1 1 1 1 Inositol hexakisphosphate RR_TM4-6 PF06459.12 EKE38684.1 - 1.5 8.6 13.0 2.4 7.9 13.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ras PF00071.22 EKE38686.1 - 1.8e-06 27.7 0.7 2.1e-06 27.4 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38686.1 - 0.012 15.8 0.1 0.023 14.9 0.1 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase MFP2b PF12150.8 EKE38686.1 - 0.018 14.3 0.5 0.021 14.1 0.5 1.1 1 0 0 1 1 1 0 Cytosolic motility protein POLO_box PF00659.18 EKE38686.1 - 0.045 14.0 0.2 0.095 12.9 0.2 1.5 1 0 0 1 1 1 0 POLO box duplicated region DICT PF10069.9 EKE38686.1 - 0.054 13.3 0.3 0.069 12.9 0.3 1.2 1 0 0 1 1 1 0 Sensory domain in DIguanylate Cyclases and Two-component system RNA_pol PF00940.19 EKE38688.1 - 0.0035 16.3 1.0 0.01 14.7 1.0 2.0 1 1 0 1 1 1 1 DNA-dependent RNA polymerase MCM_OB PF17207.3 EKE38688.1 - 0.022 14.6 0.4 0.066 13.1 0.4 1.8 1 0 0 1 1 1 0 MCM OB domain Ras PF00071.22 EKE38689.1 - 2.1e-18 66.4 0.0 4.1e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38689.1 - 2.8e-08 34.0 0.1 1.4e-07 31.8 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Salp15 PF12115.8 EKE38689.1 - 0.79 10.2 5.8 0.69 10.4 3.8 1.8 1 1 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation Snf7 PF03357.21 EKE38690.1 - 9.8e-25 87.1 16.6 1.2e-24 86.9 16.6 1.0 1 0 0 1 1 1 1 Snf7 YodL PF14191.6 EKE38690.1 - 0.067 14.0 3.3 0.098 13.5 2.7 1.6 1 1 0 1 1 1 0 YodL-like MerR-DNA-bind PF09278.11 EKE38690.1 - 0.26 11.8 0.1 0.26 11.8 0.1 2.9 3 1 0 3 3 3 0 MerR, DNA binding COG5 PF10392.9 EKE38690.1 - 0.36 11.0 9.6 38 4.5 8.6 2.5 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Syntaxin-6_N PF09177.11 EKE38690.1 - 0.44 11.1 6.5 7.7 7.2 5.8 2.4 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Wbp11 PF09429.10 EKE38690.1 - 7.7 7.0 12.8 11 6.5 7.2 2.8 2 1 1 3 3 3 0 WW domain binding protein 11 Tn7_Tnp_TnsA_C PF08721.11 EKE38691.1 - 0.052 14.2 0.5 0.12 13.0 0.0 1.8 2 0 0 2 2 2 0 TnsA endonuclease C terminal Uso1_p115_C PF04871.13 EKE38692.1 - 0.033 14.5 1.1 0.047 14.1 1.1 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region TolA_bind_tri PF16331.5 EKE38692.1 - 0.046 13.8 0.9 0.086 12.9 0.9 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation LRRFIP PF09738.9 EKE38692.1 - 0.1 12.0 0.2 0.13 11.7 0.2 1.2 1 0 0 1 1 1 0 LRRFIP family DUF4795 PF16043.5 EKE38692.1 - 0.34 10.5 2.4 0.5 9.9 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) bZIP_1 PF00170.21 EKE38692.1 - 0.37 10.9 3.2 0.78 9.9 3.2 1.5 1 0 0 1 1 1 0 bZIP transcription factor Bacillus_HBL PF05791.11 EKE38692.1 - 0.37 10.6 5.0 0.6 9.9 5.0 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF4476 PF14771.6 EKE38693.1 - 0.22 11.9 7.3 4.9 7.5 0.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4476) SNARE_assoc PF09335.11 EKE38694.1 - 5.9e-05 23.5 2.5 8.6e-05 23.0 0.2 2.4 1 1 1 2 2 2 1 SNARE associated Golgi protein Pax7 PF12360.8 EKE38694.1 - 0.26 11.5 1.9 0.52 10.6 1.9 1.4 1 0 0 1 1 1 0 Paired box protein 7 DUF1257 PF06868.11 EKE38695.1 - 0.17 12.1 4.2 7.6 6.8 1.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1257) CAP_C PF08603.11 EKE38695.1 - 1.8 8.1 62.4 0.48 10.0 7.3 7.0 4 1 3 7 7 7 0 Adenylate cyclase associated (CAP) C terminal Peptidase_A22B PF04258.13 EKE38696.1 - 2.3e-74 250.5 17.5 2.8e-74 250.2 17.5 1.0 1 0 0 1 1 1 1 Signal peptide peptidase DUF3964 PF13107.6 EKE38696.1 - 0.067 13.6 0.3 0.16 12.4 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3964) Metallophos PF00149.28 EKE38697.1 - 1.6e-29 103.9 0.0 2.3e-29 103.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Peptidase_S74 PF13884.6 EKE38698.1 - 2.1e-14 53.6 0.0 4.3e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 Chaperone of endosialidase Fibrillarin PF01269.17 EKE38698.1 - 0.032 13.3 0.1 0.77 8.8 0.0 2.2 2 0 0 2 2 2 0 Fibrillarin DNTTIP1_dimer PF18192.1 EKE38699.1 - 0.23 11.8 3.0 1.7 9.1 0.3 3.0 2 1 1 3 3 3 0 DNTTIP1 dimerisation domain SapB_2 PF03489.17 EKE38700.1 - 1.3e-06 28.4 1.0 3.4e-06 27.1 1.0 1.8 1 0 0 1 1 1 1 Saposin-like type B, region 2 SapB_1 PF05184.15 EKE38700.1 - 0.00034 20.6 1.8 0.00034 20.6 1.8 3.1 3 2 0 3 3 3 1 Saposin-like type B, region 1 Antimicrobial19 PF08225.11 EKE38700.1 - 0.053 13.1 0.6 0.27 10.9 0.2 2.1 2 0 0 2 2 2 0 Pseudin antimicrobial peptide LIM PF00412.22 EKE38702.1 - 2.3e-09 37.3 9.9 2.3e-09 37.3 9.9 2.1 2 1 0 2 2 2 1 LIM domain Cytochrom_c3_2 PF14537.6 EKE38702.1 - 0.00014 22.2 6.5 0.001 19.5 1.5 3.0 3 0 0 3 3 3 1 Cytochrome c3 DZR PF12773.7 EKE38702.1 - 0.00017 21.5 16.7 0.0012 18.9 1.3 3.2 2 1 0 2 2 2 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 EKE38702.1 - 0.0031 17.2 25.0 0.081 12.7 9.8 5.0 4 1 0 4 4 4 1 zinc-ribbon domain zf-RRN7 PF11781.8 EKE38702.1 - 0.016 14.9 17.1 0.087 12.5 0.1 4.7 4 1 0 4 4 4 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Zn-ribbon_8 PF09723.10 EKE38702.1 - 0.034 14.3 22.8 0.78 9.9 5.0 4.2 4 0 0 4 4 4 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 EKE38702.1 - 0.046 13.2 7.3 0.046 13.2 7.3 3.9 4 1 0 4 4 3 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 EKE38702.1 - 0.079 12.9 13.5 1.3 9.0 0.4 2.9 2 1 0 2 2 2 0 zinc-ribbons Cytochrome_C7 PF14522.6 EKE38702.1 - 0.093 12.7 15.2 3.8 7.6 15.2 3.0 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c zf-dskA_traR PF01258.17 EKE38702.1 - 0.25 11.3 10.1 1 9.3 0.4 4.0 4 0 0 4 4 4 0 Prokaryotic dksA/traR C4-type zinc finger Paired_CXXCH_1 PF09699.10 EKE38702.1 - 0.65 9.8 18.4 0.15 11.8 5.9 3.7 3 2 0 3 3 3 0 Doubled CXXCH motif (Paired_CXXCH_1) YacG PF03884.14 EKE38702.1 - 0.89 9.3 12.9 2.3 8.0 0.0 3.5 3 1 0 3 3 3 0 DNA gyrase inhibitor YacG zinc_ribbon_15 PF17032.5 EKE38702.1 - 0.9 10.3 14.1 0.56 11.0 0.2 3.0 2 1 0 2 2 2 0 zinc-ribbon family Cytochrome_C554 PF13435.6 EKE38702.1 - 0.96 10.4 10.7 0.56 11.2 7.0 2.5 2 1 0 2 2 2 0 Cytochrome c554 and c-prime Cytochrom_CIII PF02085.16 EKE38702.1 - 0.99 9.8 12.5 1.4 9.3 8.1 2.7 2 1 0 2 2 2 0 Class III cytochrome C family zf-C3HC4_5 PF17121.5 EKE38702.1 - 1.5 8.8 9.4 0.07 13.0 2.0 2.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-CHY PF05495.12 EKE38702.1 - 2.3 8.8 15.8 2.3 8.7 4.2 3.2 2 1 1 3 3 3 0 CHY zinc finger zinc_ribbon_11 PF11682.8 EKE38702.1 - 2.5 8.1 7.3 3.7 7.6 0.0 3.3 2 1 2 4 4 4 0 Probable zinc-ribbon zf_UBZ PF18439.1 EKE38702.1 - 4.2 7.1 18.3 5.8 6.6 0.0 4.5 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger TP6A_N PF04406.14 EKE38703.1 - 1.5e-17 63.3 0.3 2.9e-17 62.4 0.3 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF2399 PF09664.10 EKE38703.1 - 6.1e-05 23.0 0.0 0.0001 22.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2399) Leu_Phe_trans PF03588.14 EKE38703.1 - 0.031 13.8 0.0 0.075 12.6 0.0 1.6 1 0 0 1 1 1 0 Leucyl/phenylalanyl-tRNA protein transferase DUF4422 PF14393.6 EKE38703.1 - 2.9 7.7 9.2 0.95 9.3 3.5 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4422) Arf PF00025.21 EKE38704.1 - 5.6e-44 149.6 0.0 6.3e-44 149.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EKE38704.1 - 1.7e-12 47.3 0.0 2e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38704.1 - 4.2e-10 39.9 0.0 6.8e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EKE38704.1 - 2.8e-06 26.8 4.3 0.00035 19.9 0.7 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EKE38704.1 - 7.1e-06 25.6 0.0 9.2e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE38704.1 - 0.0002 21.3 0.0 0.19 11.6 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EKE38704.1 - 0.00026 20.4 0.0 0.00037 19.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE38704.1 - 0.0059 16.7 0.0 0.0081 16.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EKE38704.1 - 0.015 15.6 0.0 0.023 15.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain ODC_AZ PF02100.17 EKE38704.1 - 0.03 14.3 0.0 0.066 13.2 0.0 1.5 1 0 0 1 1 1 0 Ornithine decarboxylase antizyme Pkinase PF00069.25 EKE38706.1 - 2.1e-51 174.8 0.0 3.6e-51 174.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38706.1 - 9.9e-51 172.5 0.0 1.5e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TMEM154 PF15102.6 EKE38706.1 - 5e-07 29.7 1.2 1.3e-06 28.3 1.2 1.7 1 0 0 1 1 1 1 TMEM154 protein family Pkinase_fungal PF17667.1 EKE38706.1 - 6.7e-07 28.4 0.0 1.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE38706.1 - 5.9e-05 22.5 0.0 9.7e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Orf78 PF06024.12 EKE38706.1 - 0.0012 19.1 2.8 0.0012 19.1 2.8 2.0 2 0 0 2 2 1 1 Orf78 (ac78) DUF2207 PF09972.9 EKE38706.1 - 0.0015 17.4 0.0 0.0033 16.3 0.0 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF5305 PF17231.2 EKE38706.1 - 0.0029 17.0 1.0 0.014 14.9 0.7 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5305) Shisa PF13908.6 EKE38706.1 - 0.0039 17.4 0.7 0.0089 16.3 0.7 1.6 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator SUR7 PF06687.12 EKE38706.1 - 0.0096 15.6 3.2 0.017 14.8 3.2 1.4 1 0 0 1 1 1 1 SUR7/PalI family DUF5383 PF17355.2 EKE38706.1 - 0.012 16.0 0.6 0.012 16.0 0.6 2.8 3 0 0 3 3 2 0 Family of unknown function (DUF5383) MRAP PF15183.6 EKE38706.1 - 0.039 13.9 0.2 0.14 12.2 0.2 2.0 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family DUF4577 PF15145.6 EKE38706.1 - 0.065 13.3 0.2 0.15 12.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) DUF2615 PF11027.8 EKE38706.1 - 0.079 13.1 0.1 0.21 11.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) Stevor PF17410.2 EKE38706.1 - 0.12 11.9 4.0 0.05 13.1 1.0 1.9 2 0 0 2 2 1 0 Subtelomeric Variable Open Reading frame EphA2_TM PF14575.6 EKE38706.1 - 0.12 13.2 0.1 0.38 11.7 0.1 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain EVI2A PF05399.11 EKE38706.1 - 0.15 11.7 3.5 0.3 10.7 3.5 1.4 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Tmemb_9 PF05434.11 EKE38706.1 - 0.33 10.9 9.4 2 8.3 9.4 2.2 1 1 0 1 1 1 0 TMEM9 DUF3377 PF11857.8 EKE38706.1 - 0.4 10.6 3.0 1 9.4 3.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) RIFIN PF02009.16 EKE38706.1 - 1 9.2 7.1 0.18 11.7 1.5 2.5 3 0 0 3 3 3 0 Rifin ASFV_J13L PF05568.11 EKE38706.1 - 5 6.8 5.6 2.2 8.0 2.7 1.8 2 0 0 2 2 2 0 African swine fever virus J13L protein Baculo_11_kDa PF06143.11 EKE38706.1 - 8.9 6.0 11.0 2.3 7.8 7.0 2.0 2 0 0 2 2 2 0 Baculovirus 11 kDa family VHS PF00790.19 EKE38707.1 - 0.00052 19.9 0.1 0.017 15.0 0.0 2.7 2 1 0 2 2 2 1 VHS domain Mito_fiss_reg PF05308.11 EKE38707.1 - 0.037 14.1 6.0 0.057 13.5 5.2 1.7 1 1 0 1 1 1 0 Mitochondrial fission regulator NRDE-2 PF08424.10 EKE38707.1 - 0.049 12.7 0.1 0.082 12.0 0.1 1.3 1 0 0 1 1 1 0 NRDE-2, necessary for RNA interference 4HB_MCP_1 PF12729.7 EKE38707.1 - 0.091 12.3 4.0 0.18 11.3 3.4 1.7 1 1 1 2 2 2 0 Four helix bundle sensory module for signal transduction Cyclin_C PF02984.19 EKE38707.1 - 0.095 12.8 0.1 0.39 10.8 0.1 2.0 1 1 1 2 2 2 0 Cyclin, C-terminal domain Mem_trans PF03547.18 EKE38708.1 - 8.7e-36 123.1 9.9 1e-35 122.9 9.9 1.0 1 0 0 1 1 1 1 Membrane transport protein DUF3810 PF12725.7 EKE38708.1 - 0.048 13.0 0.1 0.048 13.0 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3810) DUF4638 PF15472.6 EKE38708.1 - 0.09 12.5 2.8 0.13 12.0 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) TT_ORF1 PF02956.14 EKE38708.1 - 1.2 7.8 8.1 1.6 7.3 8.1 1.1 1 0 0 1 1 1 0 TT viral orf 1 Carb_kinase PF01256.17 EKE38709.1 - 1.5e-55 188.3 0.0 1.7e-55 188.1 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate kinase RRM_1 PF00076.22 EKE38710.1 - 1.6e-17 63.1 0.0 3.1e-17 62.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSD PF00313.22 EKE38710.1 - 0.03 14.2 0.1 8.3 6.4 0.0 2.4 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain Fer4 PF00037.27 EKE38711.1 - 4.2e-13 48.5 18.1 1.1e-06 28.2 2.0 2.6 2 1 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EKE38711.1 - 1.6e-08 35.0 14.5 5.1e-08 33.4 14.5 1.9 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EKE38711.1 - 2.4e-08 33.7 16.3 0.00041 20.3 3.8 2.6 2 1 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 EKE38711.1 - 1.3e-07 31.6 13.4 2.7e-07 30.6 13.4 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EKE38711.1 - 3.1e-07 31.2 12.9 0.0029 18.5 1.5 2.8 2 1 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 EKE38711.1 - 6e-07 29.5 13.6 1.7e-05 24.8 15.5 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EKE38711.1 - 9.1e-07 28.9 15.9 2.3e-06 27.6 15.5 1.9 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 EKE38711.1 - 1.1e-05 25.2 21.9 0.01 15.9 7.9 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EKE38711.1 - 3e-05 24.2 19.9 0.0066 16.9 3.1 2.8 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_8 PF13183.6 EKE38711.1 - 0.00018 21.9 14.9 0.007 16.8 3.2 2.5 1 1 3 4 4 3 3 4Fe-4S dicluster domain Fer4_17 PF13534.6 EKE38711.1 - 0.00039 20.9 14.7 0.079 13.5 4.5 2.6 1 1 1 3 3 3 3 4Fe-4S dicluster domain Fer4_18 PF13746.6 EKE38711.1 - 0.00064 19.9 13.3 0.09 13.0 3.2 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 EKE38711.1 - 0.028 15.3 26.8 0.075 14.0 4.2 2.9 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_13 PF13370.6 EKE38711.1 - 0.17 12.4 15.4 0.82 10.3 1.3 2.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 EKE38711.1 - 0.23 12.3 16.1 0.97 10.3 2.6 2.7 3 0 0 3 3 3 0 4Fe-4S dicluster domain Pkinase PF00069.25 EKE38712.1 - 1.5e-19 70.4 0.9 1.8e-19 70.2 0.9 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38712.1 - 2e-10 40.4 0.4 2.6e-10 40.0 0.4 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38713.1 - 1.4e-12 47.6 0.0 1.7e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain FMN_dh PF01070.18 EKE38714.1 - 4.9e-21 75.1 0.3 3.5e-17 62.5 0.3 2.2 2 0 0 2 2 2 2 FMN-dependent dehydrogenase IMPDH PF00478.25 EKE38714.1 - 0.00054 19.1 0.2 0.0043 16.1 0.0 2.2 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain DHO_dh PF01180.21 EKE38714.1 - 0.00058 19.2 0.1 0.0009 18.5 0.1 1.4 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 EKE38714.1 - 0.014 14.6 0.0 0.25 10.4 0.0 2.4 2 0 0 2 2 2 0 Conserved region in glutamate synthase NMO PF03060.15 EKE38714.1 - 0.026 13.9 0.0 0.085 12.2 0.0 1.8 2 0 0 2 2 2 0 Nitronate monooxygenase BRCC36_C PF18110.1 EKE38717.1 - 0.0081 16.3 0.1 0.022 14.9 0.1 1.7 1 0 0 1 1 1 1 BRCC36 C-terminal helical domain LRR_5 PF13306.6 EKE38719.1 - 8.2e-49 164.8 22.4 4e-26 91.5 9.1 2.1 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE38719.1 - 4.8e-09 35.8 0.0 0.0073 16.0 0.0 4.2 1 1 3 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EKE38719.1 - 0.31 11.5 9.5 3.8 8.1 0.5 4.2 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) IBR PF01485.21 EKE38722.1 - 6.2e-14 52.0 48.4 7.6e-12 45.3 7.9 4.5 2 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EKE38722.1 - 8e-05 22.4 9.3 8e-05 22.4 9.3 5.2 3 2 3 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE38722.1 - 0.00033 20.9 8.6 0.00033 20.9 8.6 4.8 3 2 2 5 5 5 2 Ring finger domain zf-C3HC4_2 PF13923.6 EKE38722.1 - 0.00095 19.0 6.3 0.00095 19.0 6.3 5.1 3 2 2 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-NADH-PPase PF09297.11 EKE38722.1 - 0.017 14.7 0.8 0.017 14.7 0.8 5.3 5 0 0 5 5 5 0 NADH pyrophosphatase zinc ribbon domain ApoLp-III PF07464.11 EKE38723.1 - 0.00057 20.0 3.0 0.0018 18.4 0.1 2.1 2 0 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) TMPIT PF07851.13 EKE38723.1 - 0.0032 16.7 0.1 0.0055 16.0 0.1 1.3 1 0 0 1 1 1 1 TMPIT-like protein DUF1241 PF06840.11 EKE38723.1 - 0.027 14.1 0.1 0.041 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) Yuri_gagarin PF15934.5 EKE38723.1 - 0.027 14.3 0.4 0.027 14.3 0.4 1.8 2 0 0 2 2 2 0 Yuri gagarin DUF1664 PF07889.12 EKE38723.1 - 0.092 12.8 3.6 0.21 11.7 0.3 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4298 PF14131.6 EKE38723.1 - 0.18 11.8 2.5 2.1 8.3 2.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4298) Fib_alpha PF08702.10 EKE38723.1 - 2.5 8.3 8.7 7.5 6.7 2.5 2.9 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family LRR_6 PF13516.6 EKE38724.1 - 7.1 7.0 9.0 2.7 8.3 0.1 4.0 3 0 0 3 3 3 0 Leucine Rich repeat AMP-binding PF00501.28 EKE38726.1 - 3e-88 296.3 0.0 8e-88 294.9 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 EKE38726.1 - 0.046 14.7 1.0 0.94 10.5 0.1 2.5 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain Pkinase PF00069.25 EKE38727.1 - 9.7e-49 166.1 0.0 1.7e-48 165.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38727.1 - 4.2e-47 160.6 0.0 8.6e-47 159.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE38727.1 - 5.7e-05 22.1 0.0 9.5e-05 21.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE38727.1 - 0.00077 18.9 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family VSP PF03302.13 EKE38727.1 - 0.0045 15.9 121.0 12 4.6 24.7 5.4 1 1 3 4 4 4 2 Giardia variant-specific surface protein HSP70 PF00012.20 EKE38728.1 - 3e-82 276.7 8.4 2.5e-81 273.7 8.4 1.9 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE38728.1 - 1.4e-10 40.5 2.5 6.5e-09 35.1 0.7 3.1 3 1 0 3 3 3 1 MreB/Mbl protein FtsA PF14450.6 EKE38728.1 - 0.19 12.2 2.4 4 7.9 1.3 3.0 2 1 0 2 2 2 0 Cell division protein FtsA AIG1 PF04548.16 EKE38729.1 - 8.7e-11 41.5 0.3 8.7e-11 41.5 0.3 2.2 2 0 0 2 2 2 1 AIG1 family Septin PF00735.18 EKE38729.1 - 5.7e-07 29.1 0.4 5.7e-07 29.1 0.4 2.2 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EKE38729.1 - 4.7e-06 26.7 0.1 2.1e-05 24.6 0.1 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE38729.1 - 1.5e-05 24.9 1.3 8.1e-05 22.6 0.0 2.6 2 1 0 2 2 2 1 RsgA GTPase T2SSE PF00437.20 EKE38729.1 - 7.1e-05 22.0 0.0 0.00014 21.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein Zeta_toxin PF06414.12 EKE38729.1 - 0.00024 20.4 0.0 0.00092 18.5 0.0 2.0 1 0 0 1 1 1 1 Zeta toxin cobW PF02492.19 EKE38729.1 - 0.00057 19.5 0.1 0.0016 18.1 0.1 1.7 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EKE38729.1 - 0.00082 19.1 0.0 0.002 17.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EKE38729.1 - 0.0012 18.3 0.0 0.0032 16.9 0.0 1.7 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_22 PF13401.6 EKE38729.1 - 0.0015 18.8 0.2 0.0097 16.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 EKE38729.1 - 0.0047 16.5 0.1 0.017 14.7 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_14 PF13173.6 EKE38729.1 - 0.0065 16.5 1.8 0.019 15.0 0.1 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EKE38729.1 - 0.007 16.3 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EKE38729.1 - 0.014 15.8 0.0 0.028 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 EKE38729.1 - 0.028 14.6 1.2 0.093 13.0 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 EKE38729.1 - 0.036 14.2 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKE38729.1 - 0.042 13.4 0.0 0.15 11.6 0.0 1.9 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EKE38729.1 - 0.057 13.9 0.0 0.057 13.9 0.0 2.8 3 2 0 3 3 3 0 ABC transporter RNA_helicase PF00910.22 EKE38729.1 - 0.069 13.6 0.2 0.56 10.6 0.0 2.6 3 0 0 3 3 3 0 RNA helicase DUF87 PF01935.17 EKE38729.1 - 0.08 13.0 0.0 0.08 13.0 0.0 3.7 4 1 0 4 4 4 0 Helicase HerA, central domain Microtub_bd PF16796.5 EKE38729.1 - 0.084 12.8 0.2 0.084 12.8 0.2 3.5 4 0 0 4 4 4 0 Microtubule binding AAA_21 PF13304.6 EKE38729.1 - 0.53 10.0 6.4 7.2 6.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system YtxH PF12732.7 EKE38730.1 - 5.3 7.7 7.0 18 6.0 0.4 2.8 2 1 0 2 2 2 0 YtxH-like protein AMP-binding PF00501.28 EKE38731.1 - 1.3e-74 251.3 0.0 1.6e-74 251.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Nucleo_LEF-12 PF06256.11 EKE38731.1 - 0.001 18.8 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 Nucleopolyhedrovirus LEF-12 protein UPF0128 PF03673.13 EKE38731.1 - 0.0091 15.5 0.9 0.017 14.7 0.9 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0128) DUF2046 PF09755.9 EKE38732.1 - 0.0021 17.3 1.2 0.21 10.8 0.3 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein H4 (DUF2046) MatP_C PF17414.2 EKE38732.1 - 2.1 8.6 7.0 8 6.7 0.8 3.7 4 0 0 4 4 4 0 MatP C-terminal ribbon-helix-helix domain TMEM135_C_rich PF15982.5 EKE38732.1 - 9.4 6.9 8.4 29 5.3 0.3 3.1 2 1 0 3 3 3 0 N-terminal cysteine-rich region of Transmembrane protein 135 CBM_20 PF00686.19 EKE38733.1 - 3.9e-16 58.7 0.8 3.9e-16 58.7 0.8 1.5 1 1 1 2 2 2 1 Starch binding domain tRNA-synt_1b PF00579.25 EKE38733.1 - 0.014 14.7 0.0 0.017 14.5 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) AMP-binding PF00501.28 EKE38734.1 - 8.1e-72 242.1 0.0 1e-71 241.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme SH3_1 PF00018.28 EKE38734.1 - 0.034 13.8 0.1 0.1 12.2 0.0 1.9 2 0 0 2 2 2 0 SH3 domain AMP-binding_C PF13193.6 EKE38734.1 - 0.058 14.4 0.0 0.17 12.9 0.0 1.7 1 1 0 1 1 1 0 AMP-binding enzyme C-terminal domain DUF643 PF04867.12 EKE38734.1 - 0.079 13.6 0.2 0.22 12.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF643) DUF4304 PF14137.6 EKE38735.1 - 3.9 7.6 11.4 0.72 10.0 0.6 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4304) RasGEF PF00617.19 EKE38736.1 - 9.3e-21 74.8 6.5 2e-20 73.7 6.5 1.6 1 0 0 1 1 1 1 RasGEF domain YlbD_coat PF14071.6 EKE38736.1 - 0.018 15.3 3.2 2.8 8.2 0.1 3.1 3 0 0 3 3 3 0 Putative coat protein DUF4355 PF14265.6 EKE38736.1 - 0.076 13.3 0.1 0.076 13.3 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) FcoT PF10862.8 EKE38736.1 - 0.098 12.2 1.8 0.18 11.4 1.8 1.4 1 0 0 1 1 1 0 FcoT-like thioesterase domain Glycos_transf_2 PF00535.26 EKE38737.1 - 2.7e-29 102.1 0.0 4.1e-29 101.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 GtrA PF04138.14 EKE38737.1 - 4.3e-23 81.8 8.1 4.3e-23 81.8 8.1 1.6 2 0 0 2 2 2 1 GtrA-like protein Glyco_tranf_2_3 PF13641.6 EKE38737.1 - 2.2e-07 31.0 0.1 3.3e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EKE38737.1 - 1.6e-05 24.5 0.0 2.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF2271 PF10029.9 EKE38737.1 - 0.19 11.4 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2271) Rhodanese PF00581.20 EKE38738.1 - 0.00031 21.2 2.1 0.00062 20.3 0.0 2.6 4 0 0 4 4 4 1 Rhodanese-like domain RabGAP-TBC PF00566.18 EKE38738.1 - 0.00041 20.1 2.4 0.00041 20.1 2.4 3.3 3 1 0 3 3 3 1 Rab-GTPase-TBC domain bPH_3 PF14470.6 EKE38738.1 - 0.0034 17.7 1.7 0.016 15.6 1.1 2.4 2 0 0 2 2 2 1 Bacterial PH domain Helicase_C_2 PF13307.6 EKE38739.1 - 7.4e-57 192.2 0.4 3.2e-56 190.2 0.1 2.2 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EKE38739.1 - 9.1e-25 87.3 0.5 2.4e-24 85.9 0.5 1.8 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 EKE38739.1 - 1.3e-05 25.1 1.6 0.00091 19.0 0.1 3.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 EKE38739.1 - 0.00019 21.5 8.5 0.0012 18.9 0.0 3.4 4 0 0 4 4 4 2 Type III restriction enzyme, res subunit T2SSE PF00437.20 EKE38739.1 - 0.11 11.6 0.0 0.23 10.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein RPN7 PF10602.9 EKE38740.1 - 1.4e-16 60.7 0.1 3.9e-16 59.3 0.0 1.7 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 EKE38740.1 - 1.4e-10 41.6 0.3 1.4e-10 41.6 0.3 1.7 2 0 0 2 2 2 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 EKE38740.1 - 0.0063 16.5 0.2 0.028 14.4 0.1 1.9 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family DNA_topoisoIV PF00521.20 EKE38740.1 - 0.013 14.4 0.9 0.022 13.7 0.9 1.4 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A DUF1269 PF06897.12 EKE38741.1 - 0.11 12.8 0.5 0.29 11.4 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) PP2C_2 PF13672.6 EKE38743.1 - 4e-09 36.4 0.0 6.1e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE38743.1 - 0.0092 15.9 0.0 0.025 14.5 0.0 1.7 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Hus1 PF04005.12 EKE38744.1 - 2.6e-27 95.7 0.7 3.2e-27 95.4 0.7 1.1 1 0 0 1 1 1 1 Hus1-like protein Ras PF00071.22 EKE38745.1 - 6.5e-13 48.6 0.1 1.3e-12 47.6 0.1 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EKE38745.1 - 7.6e-06 26.1 0.0 2e-05 24.8 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RNA_pol_L_2 PF13656.6 EKE38745.1 - 0.017 14.9 0.1 0.18 11.6 0.0 2.3 1 1 1 2 2 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Nucleoside_tran PF01733.18 EKE38746.1 - 3.5e-14 52.9 5.8 3.5e-14 52.9 5.8 3.1 1 1 1 2 2 2 1 Nucleoside transporter CAML PF14963.6 EKE38746.1 - 3.8 7.5 4.7 1.6 8.8 0.0 2.1 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand Peptidase_C54 PF03416.19 EKE38747.1 - 4.9e-39 134.4 0.5 2.4e-38 132.1 0.5 1.9 1 1 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 EKE38747.1 - 0.032 13.7 0.0 0.38 10.2 0.0 2.1 2 0 0 2 2 2 0 Peptidase family C78 Erv26 PF04148.13 EKE38749.1 - 2.1e-13 50.6 16.6 9.7e-13 48.4 16.6 1.8 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 TLD PF07534.16 EKE38750.1 - 4.4e-06 27.0 0.6 7.1e-06 26.3 0.6 1.4 1 0 0 1 1 1 1 TLD BRE1 PF08647.11 EKE38750.1 - 0.02 14.9 0.9 0.034 14.2 0.9 1.3 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase TPR_MLP1_2 PF07926.12 EKE38750.1 - 0.046 13.8 0.5 0.072 13.2 0.5 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein IL6 PF00489.17 EKE38750.1 - 0.17 11.5 2.3 0.23 11.0 2.3 1.3 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family DUF948 PF06103.11 EKE38750.1 - 0.17 12.2 0.4 0.3 11.3 0.4 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) SNF2_N PF00176.23 EKE38751.1 - 1.6e-60 204.7 1.4 3.2e-60 203.7 1.4 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE38751.1 - 8.3e-21 74.4 0.0 2.7e-20 72.8 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 EKE38751.1 - 2.9e-12 46.3 7.0 1.7e-06 27.8 1.5 3.8 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain Rad9 PF04139.13 EKE38752.1 - 4.4e-05 23.1 3.2 0.041 13.3 0.4 2.3 1 1 1 2 2 2 2 Rad9 PCNA_N PF00705.18 EKE38752.1 - 0.032 13.9 0.0 0.053 13.2 0.0 1.4 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, N-terminal domain LRR_5 PF13306.6 EKE38753.1 - 4.6e-67 223.8 53.6 2.5e-25 88.9 13.8 3.5 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE38753.1 - 2.6e-12 46.3 12.4 0.018 14.8 0.1 6.3 2 1 5 7 7 7 5 Leucine rich repeat DUF1484 PF07363.11 EKE38753.1 - 0.3 12.1 1.5 64 4.6 0.1 3.5 2 1 0 3 3 3 0 Protein of unknown function (DUF1484) FNIP PF05725.12 EKE38753.1 - 1.8 8.8 23.9 7.8 6.8 0.0 7.0 3 2 2 5 5 5 0 FNIP Repeat TBPIP PF07106.13 EKE38754.1 - 9.8e-19 67.1 0.7 9.8e-19 67.1 0.7 2.0 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain LZ3wCH PF18517.1 EKE38754.1 - 9e-07 28.9 1.1 9e-07 28.9 1.1 2.5 2 1 1 3 3 3 1 Leucine zipper with capping helix domain DUF1192 PF06698.11 EKE38754.1 - 0.025 14.6 0.7 0.025 14.6 0.7 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Osmo_CC PF08946.10 EKE38754.1 - 0.028 14.7 3.3 3.1 8.1 1.2 2.9 2 0 0 2 2 2 0 Osmosensory transporter coiled coil NAPRTase_C PF17956.1 EKE38754.1 - 0.066 13.6 3.5 0.087 13.3 0.4 2.3 1 1 1 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain Prominin PF05478.11 EKE38754.1 - 0.19 9.7 5.3 0.21 9.5 5.3 1.1 1 0 0 1 1 1 0 Prominin V_ATPase_I PF01496.19 EKE38754.1 - 0.34 8.8 9.1 0.41 8.5 9.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Swi5 PF07061.11 EKE38754.1 - 0.4 10.8 14.5 2.7 8.2 5.5 3.1 1 1 1 2 2 2 0 Swi5 TAP42 PF04177.12 EKE38755.1 - 1.9e-42 145.5 21.4 2.6e-42 145.1 21.4 1.1 1 0 0 1 1 1 1 TAP42-like family PFK PF00365.20 EKE38756.1 - 3.9e-39 134.7 0.2 2.1e-38 132.3 0.2 2.1 1 1 0 1 1 1 1 Phosphofructokinase Lipoprotein_9 PF03180.14 EKE38756.1 - 0.023 13.8 0.0 0.057 12.5 0.0 1.6 1 0 0 1 1 1 0 NLPA lipoprotein Peptidase_S10 PF00450.22 EKE38756.1 - 0.045 13.1 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase PNP_UDP_1 PF01048.20 EKE38757.1 - 3.5e-36 124.6 0.0 3.9e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily NUP PF06516.11 EKE38757.1 - 0.057 12.6 0.2 0.21 10.8 0.0 1.9 2 1 0 2 2 2 0 Purine nucleoside permease (NUP) SCP-1 PF05483.12 EKE38758.1 - 0.35 8.8 4.1 0.51 8.3 4.1 1.1 1 0 0 1 1 1 0 Synaptonemal complex protein 1 (SCP-1) RhoGAP PF00620.27 EKE38759.1 - 4.5e-28 98.0 0.0 1.1e-27 96.8 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain Phage_GPO PF05929.11 EKE38759.1 - 0.0076 15.9 0.0 0.015 14.9 0.0 1.4 1 1 0 1 1 1 1 Phage capsid scaffolding protein (GPO) serine peptidase Imm26 PF15428.6 EKE38759.1 - 0.034 14.4 0.0 0.14 12.4 0.0 2.1 1 0 0 1 1 1 0 Immunity protein 26 PI3Ka PF00613.20 EKE38760.1 - 0.0001 21.8 0.0 0.00012 21.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2538 PF10804.8 EKE38760.1 - 0.14 11.9 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2538) IPPT PF01715.17 EKE38761.1 - 0.033 14.0 0.0 0.053 13.3 0.0 1.2 1 0 0 1 1 1 0 IPP transferase HSP70 PF00012.20 EKE38762.1 - 1.2e-99 334.2 6.1 1.4e-99 334.0 6.1 1.0 1 0 0 1 1 1 1 Hsp70 protein CENP-X PF09415.10 EKE38762.1 - 0.047 14.0 1.9 0.12 12.7 1.9 1.7 1 0 0 1 1 1 0 CENP-S associating Centromere protein X HSP70 PF00012.20 EKE38763.1 - 1.5e-87 294.2 2.4 1.8e-87 293.9 2.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE38763.1 - 2.3e-07 30.0 0.8 0.0014 17.6 0.2 2.1 2 0 0 2 2 2 2 MreB/Mbl protein GPR15L PF15854.5 EKE38763.1 - 0.072 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 G-protein coupled receptor ligand 15 DUF722 PF05263.11 EKE38763.1 - 0.098 12.9 0.1 0.15 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF722) UPF0102 PF02021.17 EKE38763.1 - 0.12 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0102 SKIP_SNW PF02731.15 EKE38764.1 - 1.5e-56 190.5 9.9 1.5e-56 190.5 9.9 2.1 1 1 1 2 2 2 1 SKIP/SNW domain SAM_decarbox PF01536.16 EKE38764.1 - 0.37 9.7 3.6 0.57 9.1 3.6 1.3 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase Vfa1 PF08432.10 EKE38764.1 - 0.83 10.0 13.7 1.3 9.3 13.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1090 PF06476.12 EKE38764.1 - 2.7 8.1 22.4 2 8.6 19.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1090) UCH PF00443.29 EKE38765.1 - 5.9e-46 157.0 5.2 5.9e-46 157.0 5.2 1.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE38765.1 - 2.1e-18 67.0 4.0 2.1e-18 67.0 4.0 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF1493 PF07377.12 EKE38765.1 - 0.69 10.4 5.3 0.77 10.3 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1493) TruD PF01142.18 EKE38766.1 - 1.5e-67 228.3 0.8 7.4e-66 222.7 0.1 2.2 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) DHOase PF12890.7 EKE38766.1 - 0.018 14.9 0.0 0.31 10.9 0.0 2.3 1 1 1 2 2 2 0 Dihydro-orotase-like 40S_S4_C PF16121.5 EKE38766.1 - 0.098 12.3 0.0 0.57 9.9 0.0 2.3 1 0 0 1 1 1 0 40S ribosomal protein S4 C-terminus DUF1953 PF09196.10 EKE38766.1 - 0.13 12.1 0.7 0.47 10.3 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1953) DUF1318 PF07027.12 EKE38767.1 - 0.11 12.9 0.1 0.31 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1318) a_DG1_N2 PF18424.1 EKE38768.1 - 0.012 15.7 0.0 0.048 13.8 0.0 2.0 2 0 0 2 2 2 0 Alpha-Dystroglycan N-terminal domain 2 Rav1p_C PF12234.8 EKE38769.1 - 0.0057 15.1 0.4 0.0064 15.0 0.4 1.0 1 0 0 1 1 1 1 RAVE protein 1 C terminal Sigma70_ner PF04546.13 EKE38769.1 - 0.0067 16.3 3.7 0.008 16.1 3.7 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region DUF5089 PF17002.5 EKE38769.1 - 0.024 14.5 2.2 0.028 14.3 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) FAM176 PF14851.6 EKE38769.1 - 0.036 13.7 2.1 0.043 13.5 2.1 1.1 1 0 0 1 1 1 0 FAM176 family CpxA_peri PF16527.5 EKE38769.1 - 0.092 13.1 0.2 0.12 12.7 0.2 1.2 1 0 0 1 1 1 0 Two-component sensor protein CpxA, periplasmic domain Pox_RNA_Pol_19 PF05320.12 EKE38769.1 - 0.13 12.3 3.9 0.18 11.7 3.9 1.2 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit PRA1 PF03208.19 EKE38770.1 - 5.2e-07 29.4 2.4 7e-07 29.0 2.4 1.1 1 0 0 1 1 1 1 PRA1 family protein Phage_Gp23 PF10669.9 EKE38770.1 - 0.0019 18.5 0.3 0.0034 17.7 0.3 1.4 1 0 0 1 1 1 1 Protein gp23 (Bacteriophage A118) Flp1_like PF16982.5 EKE38770.1 - 0.011 15.1 0.1 0.22 11.0 0.0 2.4 2 0 0 2 2 2 0 Putative Flagellin, Flp1-like, domain AP3D1 PF06375.11 EKE38770.1 - 0.052 13.8 8.2 0.077 13.2 8.2 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4834 PF16118.5 EKE38770.1 - 0.055 14.4 0.1 0.055 14.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 EKE38770.1 - 0.062 13.0 0.4 0.094 12.4 0.4 1.3 1 0 0 1 1 1 0 FAM176 family DUF2500 PF10694.9 EKE38770.1 - 0.16 12.5 1.8 0.99 9.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) DUF755 PF05501.11 EKE38770.1 - 0.2 11.9 20.3 0.31 11.3 20.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Ctr PF04145.15 EKE38770.1 - 0.27 11.8 2.0 0.51 10.9 2.0 1.7 1 1 0 1 1 1 0 Ctr copper transporter family DUF2207 PF09972.9 EKE38770.1 - 4.9 5.8 9.0 6.9 5.3 6.4 2.1 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Profilin PF00235.19 EKE38771.1 - 1.6e-09 38.1 0.0 1.8e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 Profilin DUF3883 PF13020.6 EKE38772.1 - 2.3e-22 78.8 0.2 2.3e-22 78.8 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3883) PPTA PF01239.22 EKE38773.1 - 0.00035 20.2 9.3 0.2 11.4 0.4 4.0 4 0 0 4 4 4 2 Protein prenyltransferase alpha subunit repeat DUF1749 PF08538.10 EKE38774.1 - 2.3e-35 122.1 0.1 2.8e-35 121.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_1 PF00561.20 EKE38774.1 - 8.1e-06 25.7 0.0 2.4e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EKE38774.1 - 9.8e-06 25.0 0.0 2.9e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EKE38774.1 - 0.00046 20.9 0.0 0.00053 20.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.12 EKE38774.1 - 0.00051 19.6 0.1 0.00072 19.1 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Ser_hydrolase PF06821.13 EKE38774.1 - 0.00082 19.3 0.0 0.024 14.5 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase LIDHydrolase PF10230.9 EKE38774.1 - 0.0061 16.1 3.7 0.013 15.1 1.2 2.2 1 1 2 3 3 3 1 Lipid-droplet associated hydrolase Chlorophyllase2 PF12740.7 EKE38774.1 - 0.13 11.2 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF4347 PF14252.6 EKE38774.1 - 0.15 11.9 0.2 0.28 11.0 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4347) DUF1803 PF08820.10 EKE38774.1 - 0.45 10.6 5.3 0.7 10.0 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1803) Archease PF01951.16 EKE38775.1 - 8.3e-23 81.2 0.6 9.2e-23 81.0 0.6 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) PHZA_PHZB PF03284.13 EKE38775.1 - 0.13 11.9 0.7 0.31 10.7 0.7 1.6 1 1 0 1 1 1 0 Phenazine biosynthesis protein A/B DUF3219 PF11514.8 EKE38776.1 - 0.03 14.3 0.8 0.11 12.6 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3219) UspB PF10625.9 EKE38776.1 - 0.038 14.0 0.1 2.2 8.3 0.0 2.8 2 0 0 2 2 2 0 Universal stress protein B (UspB) LIM PF00412.22 EKE38776.1 - 6.1 7.2 9.2 0.099 12.9 1.4 2.2 2 0 0 2 2 2 0 LIM domain PIN_5 PF08745.11 EKE38779.1 - 0.06 12.8 5.2 0.53 9.7 0.0 2.8 3 0 0 3 3 3 0 PINc domain ribonuclease Inositol_P PF00459.25 EKE38780.1 - 3.5e-62 210.4 0.0 7.6e-62 209.3 0.0 1.4 1 1 1 2 2 2 1 Inositol monophosphatase family Galactosyl_T PF01762.21 EKE38782.1 - 2.4e-16 60.1 0.3 3.8e-16 59.5 0.3 1.2 1 0 0 1 1 1 1 Galactosyltransferase PP2C_2 PF13672.6 EKE38783.1 - 5.8e-11 42.4 0.0 9.1e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C TIP49 PF06068.13 EKE38783.1 - 0.036 13.3 0.1 5.7 6.0 0.0 2.1 2 0 0 2 2 2 0 TIP49 P-loop domain SpoIIE PF07228.12 EKE38783.1 - 0.048 13.6 0.0 0.09 12.7 0.0 1.5 1 1 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) Got1 PF04178.12 EKE38784.1 - 2.4e-15 56.9 29.6 3.5e-15 56.4 29.3 1.4 1 1 0 1 1 1 1 Got1/Sft2-like family WD40_like PF17005.5 EKE38785.1 - 0.02 14.2 9.0 0.032 13.6 1.8 2.6 2 1 1 3 3 3 0 WD40-like domain PQQ_3 PF13570.6 EKE38785.1 - 0.042 14.3 0.0 22 5.7 0.0 3.2 3 0 0 3 3 3 0 PQQ-like domain ATP_bind_3 PF01171.20 EKE38786.1 - 6.2e-18 65.2 0.0 7.9e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 PP-loop family NAD_synthase PF02540.17 EKE38786.1 - 0.00025 20.3 0.0 0.00034 19.8 0.0 1.1 1 0 0 1 1 1 1 NAD synthase Diphthami_syn_2 PF01902.17 EKE38786.1 - 0.0011 18.5 0.0 0.0021 17.6 0.0 1.4 1 0 0 1 1 1 1 Diphthamide synthase tRNA_Me_trans PF03054.16 EKE38786.1 - 0.013 14.3 0.0 0.045 12.5 0.0 1.7 1 1 0 1 1 1 0 tRNA methyl transferase QueH PF02677.14 EKE38786.1 - 0.028 14.5 0.3 1.9 8.5 0.0 2.2 1 1 1 2 2 2 0 Epoxyqueuosine reductase QueH ParA PF10609.9 EKE38787.1 - 4.1e-88 295.0 0.0 4.8e-88 294.8 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EKE38787.1 - 5.5e-11 42.6 0.2 1.9e-10 40.9 0.2 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EKE38787.1 - 1.6e-06 28.1 0.5 5e-06 26.6 0.2 1.9 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 EKE38787.1 - 6.6e-06 25.5 3.6 4.4e-05 22.8 0.8 2.3 2 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 EKE38787.1 - 3.3e-05 23.3 0.1 0.00013 21.3 0.1 1.9 1 1 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.6 EKE38787.1 - 0.00061 19.7 0.4 0.11 12.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EKE38787.1 - 0.0015 17.9 0.1 0.072 12.4 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin AAA_25 PF13481.6 EKE38787.1 - 0.0016 18.0 0.1 0.0031 17.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 EKE38787.1 - 0.0027 16.8 0.2 0.0041 16.1 0.2 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 EKE38787.1 - 0.004 17.0 0.1 0.0062 16.4 0.1 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase NB-ARC PF00931.22 EKE38787.1 - 0.0063 15.7 0.2 0.0099 15.1 0.2 1.2 1 0 0 1 1 1 1 NB-ARC domain CLP1_P PF16575.5 EKE38787.1 - 0.0072 16.1 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop IstB_IS21 PF01695.17 EKE38787.1 - 0.009 15.8 0.0 0.061 13.1 0.1 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein MMR_HSR1 PF01926.23 EKE38787.1 - 0.01 15.9 1.6 1.6 8.8 0.5 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EKE38787.1 - 0.014 15.8 0.7 0.21 12.0 0.1 2.5 3 0 0 3 3 2 0 RNA helicase RsgA_GTPase PF03193.16 EKE38787.1 - 0.016 15.1 0.3 0.04 13.8 0.3 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 EKE38787.1 - 0.017 15.7 0.1 0.034 14.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EKE38787.1 - 0.022 15.2 0.3 0.04 14.3 0.3 1.4 1 0 0 1 1 1 0 AAA ATPase domain CBP_BcsQ PF06564.12 EKE38787.1 - 0.042 13.3 0.2 0.079 12.4 0.2 1.4 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 EKE38787.1 - 0.058 12.8 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family DZR PF12773.7 EKE38787.1 - 0.069 13.2 0.2 0.14 12.2 0.2 1.4 1 0 0 1 1 1 0 Double zinc ribbon AAA PF00004.29 EKE38787.1 - 0.07 13.6 0.1 0.16 12.4 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zinc_ribbon_9 PF14369.6 EKE38787.1 - 0.12 12.7 0.8 0.26 11.6 0.8 1.5 1 0 0 1 1 1 0 zinc-ribbon SRP54 PF00448.22 EKE38787.1 - 0.12 12.0 0.9 0.31 10.6 0.3 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 EKE38787.1 - 0.18 12.3 0.1 0.26 11.8 0.1 1.4 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EKE38787.1 - 0.23 11.2 0.4 0.48 10.1 0.4 1.7 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.9 EKE38787.1 - 0.26 10.4 0.1 9 5.4 0.2 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 SMK-1 PF04802.15 EKE38788.1 - 2.8e-13 50.1 5.1 2.8e-13 50.1 5.1 3.0 3 0 0 3 3 3 2 Component of IIS longevity pathway SMK-1 Pkinase_Tyr PF07714.17 EKE38789.1 - 2.3e-32 112.3 0.0 2.8e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38789.1 - 5.6e-28 98.0 0.0 7.2e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Peptidase_M64 PF09471.10 EKE38789.1 - 0.02 14.4 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 IgA Peptidase M64 Metallophos PF00149.28 EKE38790.1 - 1.3e-21 78.1 0.1 1.9e-21 77.5 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_1 PF00515.28 EKE38790.1 - 5e-12 45.1 4.9 9e-06 25.3 0.4 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKE38790.1 - 2.3e-09 36.8 2.6 1.7e-05 24.4 0.6 3.2 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.17 EKE38790.1 - 4.9e-09 35.6 2.5 7.7e-06 25.6 0.2 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EKE38790.1 - 2.1e-07 30.6 1.0 0.014 15.6 0.2 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EKE38790.1 - 1.3e-05 25.2 9.4 0.0071 16.6 1.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EKE38790.1 - 7.9e-05 22.7 0.0 0.0012 18.9 0.0 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EKE38790.1 - 8.4e-05 23.1 0.3 0.072 13.8 0.0 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EKE38790.1 - 0.0069 17.1 0.0 1 10.3 0.0 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EKE38790.1 - 0.0083 16.4 1.1 0.028 14.7 0.5 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EKE38790.1 - 0.013 16.0 0.6 0.68 10.5 0.2 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat ChAPs PF09295.10 EKE38790.1 - 0.019 14.0 0.0 0.033 13.2 0.0 1.4 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) ANAPC3 PF12895.7 EKE38790.1 - 0.024 14.9 1.9 0.054 13.7 1.8 1.7 2 0 0 2 2 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EKE38790.1 - 0.061 13.4 0.8 0.22 11.6 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Metallophos_2 PF12850.7 EKE38790.1 - 0.1 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain SHNi-TPR PF10516.9 EKE38790.1 - 0.11 11.9 0.1 0.37 10.3 0.0 1.9 2 0 0 2 2 2 0 SHNi-TPR MIT PF04212.18 EKE38790.1 - 0.14 12.3 0.7 0.46 10.6 0.7 1.9 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 EKE38790.1 - 1.6 9.5 3.8 8.6 7.2 0.1 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF2663 PF10864.8 EKE38791.1 - 0.0087 16.5 4.9 0.012 16.0 4.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2663) DUF2723 PF11028.8 EKE38791.1 - 0.25 11.2 6.0 0.29 11.0 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2723) DUF2207 PF09972.9 EKE38791.1 - 0.28 9.9 4.2 0.31 9.8 4.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Sulfotransfer_3 PF13469.6 EKE38792.1 - 8.3e-18 65.6 0.0 3.1e-17 63.7 0.0 1.9 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EKE38792.1 - 1.5e-05 24.6 1.2 6.1e-05 22.6 1.2 1.9 1 1 0 1 1 1 1 Sulfotransferase domain Ras PF00071.22 EKE38794.1 - 8.6e-43 145.7 0.3 1.1e-42 145.5 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38794.1 - 1.4e-29 102.8 0.0 2.1e-29 102.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38794.1 - 2.9e-16 59.4 0.1 3.6e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE38794.1 - 3.4e-06 27.1 0.0 5e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE38794.1 - 8.1e-06 25.3 0.1 9.7e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EKE38794.1 - 0.0001 22.6 0.0 0.00034 20.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 EKE38794.1 - 0.00011 21.9 0.2 0.0013 18.3 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKE38794.1 - 0.00025 20.5 0.1 0.00033 20.1 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit TniB PF05621.11 EKE38794.1 - 0.0022 17.4 0.0 0.0051 16.2 0.0 1.6 1 0 0 1 1 1 1 Bacterial TniB protein RsgA_GTPase PF03193.16 EKE38794.1 - 0.0028 17.6 0.0 1.1 9.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 EKE38794.1 - 0.0042 16.8 0.2 0.006 16.3 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EKE38794.1 - 0.0085 15.6 0.1 0.015 14.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region NACHT PF05729.12 EKE38794.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 EKE38794.1 - 0.021 15.2 0.0 0.028 14.8 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain DUF4852 PF16144.5 EKE38794.1 - 0.024 14.8 0.1 0.053 13.6 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4852) PduV-EutP PF10662.9 EKE38794.1 - 0.03 14.1 0.3 0.39 10.5 0.1 2.4 1 1 2 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 EKE38794.1 - 0.04 13.2 0.1 0.061 12.6 0.1 1.3 1 0 0 1 1 1 0 Septin ATPase PF06745.13 EKE38794.1 - 0.048 13.0 0.0 0.087 12.2 0.0 1.5 1 1 0 1 1 1 0 KaiC Sigma54_activat PF00158.26 EKE38794.1 - 0.14 11.8 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DOCK-C2 PF14429.6 EKE38795.1 - 1.7e-22 80.2 2.1 4e-22 79.0 2.1 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DHR-2 PF06920.13 EKE38795.1 - 1.5e-14 53.6 10.3 2.5e-14 52.8 5.0 4.9 4 1 0 4 4 4 2 Dock homology region 2 DEC-1_N PF04625.13 EKE38795.1 - 0.022 13.8 1.3 0.038 13.0 1.3 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region EF-hand_7 PF13499.6 EKE38795.1 - 0.45 11.0 3.0 1.1 9.8 0.8 3.1 3 0 0 3 3 3 0 EF-hand domain pair Cad PF03596.13 EKE38796.1 - 0.055 13.4 0.2 0.21 11.5 0.1 1.9 1 1 0 2 2 2 0 Cadmium resistance transporter RhoGAP PF00620.27 EKE38797.1 - 1.3e-32 112.7 2.1 1e-31 109.8 0.1 2.1 2 0 0 2 2 2 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 EKE38797.1 - 9.2e-07 29.1 1.6 9.2e-07 29.1 1.6 1.8 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EKE38797.1 - 0.00037 20.2 1.8 0.001 18.8 1.8 1.7 1 0 0 1 1 1 1 CRAL/TRIO domain MitMem_reg PF13012.6 EKE38797.1 - 0.03 14.7 1.0 0.045 14.2 0.1 1.8 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function DUF572 PF04502.13 EKE38798.1 - 9.5e-38 130.6 0.8 1e-37 130.5 0.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) ubiquitin PF00240.23 EKE38799.1 - 4.1e-05 23.2 0.8 9.7e-05 22.1 0.8 1.6 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EKE38799.1 - 0.0012 18.7 0.9 0.0063 16.4 0.1 2.3 2 0 0 2 2 2 1 UBA/TS-N domain DUF2407 PF10302.9 EKE38799.1 - 0.0013 19.2 0.6 0.0044 17.5 0.3 2.0 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain STI1 PF17830.1 EKE38799.1 - 0.094 12.7 7.7 0.06 13.3 5.0 2.0 2 0 0 2 2 2 0 STI1 domain MMM1 PF10296.9 EKE38800.1 - 2e-07 30.4 0.5 3.3e-07 29.7 0.5 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Receptor_IA-2 PF11548.8 EKE38801.1 - 0.053 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase receptor IA-2 DnaJ_C PF01556.18 EKE38804.1 - 0.0097 16.0 0.1 0.071 13.2 0.1 2.2 2 0 0 2 2 2 1 DnaJ C terminal domain HAUS-augmin3 PF14932.6 EKE38805.1 - 0.0098 15.5 4.1 0.014 15.0 4.1 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 RGS PF00615.19 EKE38805.1 - 0.11 12.8 3.2 12 6.2 2.3 3.3 2 1 0 2 2 2 0 Regulator of G protein signaling domain Med9 PF07544.13 EKE38805.1 - 0.2 11.8 3.2 0.61 10.2 3.1 1.9 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 RhoGEF PF00621.20 EKE38807.1 - 8.4e-10 39.2 10.3 8.4e-10 39.2 10.3 2.6 2 0 0 2 2 2 1 RhoGEF domain FCH PF00611.23 EKE38808.1 - 9.2e-05 22.7 0.3 9.2e-05 22.7 0.3 3.2 3 1 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain PMEI PF04043.15 EKE38808.1 - 0.18 12.2 2.7 0.37 11.1 2.5 1.8 1 1 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor DUF4019 PF13211.6 EKE38808.1 - 0.19 12.1 2.4 3.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4019) SLATT_6 PF18169.1 EKE38808.1 - 1.5 8.4 8.8 0.93 9.1 5.4 2.1 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 Exonuc_VII_L PF02601.15 EKE38808.1 - 2.4 7.6 18.0 25 4.3 14.4 2.6 1 1 1 2 2 2 0 Exonuclease VII, large subunit Pkinase_Tyr PF07714.17 EKE38809.1 - 1.1e-58 198.6 0.0 1.6e-58 198.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE38809.1 - 2.9e-52 177.7 0.0 5.5e-52 176.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.24 EKE38809.1 - 5.8e-10 39.1 6.8 1e-07 31.9 0.9 3.3 3 0 0 3 3 3 2 IPT/TIG domain TIG_plexin PF17960.1 EKE38809.1 - 9.2e-05 22.4 0.1 0.0021 18.0 0.0 2.6 2 0 0 2 2 2 1 TIG domain Haspin_kinase PF12330.8 EKE38809.1 - 0.00014 21.0 1.1 0.006 15.6 1.1 2.5 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EKE38809.1 - 0.0089 14.8 0.0 0.019 13.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Anth_Ig PF05587.13 EKE38809.1 - 0.033 14.5 0.6 0.033 14.5 0.6 2.4 3 0 0 3 3 3 0 Anthrax receptor extracellular domain APH PF01636.23 EKE38809.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Rpn9_C PF18261.1 EKE38810.1 - 0.098 12.3 3.7 5.5 6.7 0.1 3.0 2 0 0 2 2 2 0 Rpn9 C-terminal helix TLD PF07534.16 EKE38811.1 - 5.2e-07 30.0 0.8 1.2e-06 28.8 0.8 1.7 1 1 0 1 1 1 1 TLD FAT PF02259.23 EKE38812.1 - 2e-65 221.3 18.6 6.7e-65 219.6 10.7 2.4 2 1 0 2 2 2 2 FAT domain FRB_dom PF08771.11 EKE38812.1 - 6.9e-32 109.8 0.2 6.9e-32 109.8 0.2 3.5 5 0 0 5 5 5 1 FKBP12-rapamycin binding domain TPR_19 PF14559.6 EKE38812.1 - 2.6e-06 27.8 0.5 0.024 15.2 0.0 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE38812.1 - 0.00024 21.3 2.1 3.2 8.1 0.1 4.8 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EKE38812.1 - 0.00085 19.2 4.0 0.0067 16.4 0.1 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EKE38812.1 - 0.024 15.2 1.7 24 5.8 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Flg_bbr_C PF06429.13 EKE38812.1 - 0.035 14.2 0.5 0.12 12.5 0.5 1.9 1 0 0 1 1 1 0 Flagellar basal body rod FlgEFG protein C-terminal Nipped-B_C PF12830.7 EKE38812.1 - 0.041 13.8 0.1 0.6 10.0 0.0 2.6 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus Docking PF08990.11 EKE38812.1 - 1.3 8.7 3.1 4 7.1 0.2 2.5 2 0 0 2 2 2 0 Erythronolide synthase docking C2 PF00168.30 EKE38813.1 - 7.6e-35 119.3 0.2 7.4e-19 68.0 0.0 3.1 3 1 0 3 3 3 2 C2 domain Pro-rich PF15240.6 EKE38813.1 - 0.02 15.2 49.2 0.037 14.3 49.2 1.4 1 0 0 1 1 1 0 Proline-rich LCAT PF02450.15 EKE38814.1 - 1.2e-32 113.5 2.4 1.5e-30 106.7 1.0 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 EKE38814.1 - 0.0058 16.4 0.0 0.5 10.0 0.0 2.2 2 0 0 2 2 2 2 PGAP1-like protein Flavodoxin_1 PF00258.25 EKE38815.1 - 5e-08 33.3 0.0 1.7e-07 31.5 0.0 1.9 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EKE38815.1 - 0.0022 18.3 0.0 0.0042 17.3 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin domain Lactamase_B PF00753.27 EKE38815.1 - 0.0024 17.9 0.0 0.0072 16.3 0.0 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily DUF1256 PF06866.11 EKE38815.1 - 0.0075 15.7 0.6 0.2 11.1 0.1 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1256) Lactamase_B_2 PF12706.7 EKE38815.1 - 0.0094 15.5 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain IPK PF03770.16 EKE38816.1 - 3.3e-35 121.7 3.3 8.1e-35 120.5 3.3 1.6 1 1 0 1 1 1 1 Inositol polyphosphate kinase Peptidase_S74 PF13884.6 EKE38817.1 - 3.4e-11 43.3 0.0 6.5e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Chaperone of endosialidase Flg_bbr_C PF06429.13 EKE38817.1 - 0.062 13.4 0.4 0.56 10.4 0.0 2.2 2 0 0 2 2 2 0 Flagellar basal body rod FlgEFG protein C-terminal Fusion_gly PF00523.18 EKE38817.1 - 0.12 10.6 0.8 0.19 9.9 0.8 1.3 1 0 0 1 1 1 0 Fusion glycoprotein F0 Peptidase_U4 PF03419.13 EKE38817.1 - 0.38 10.0 7.3 0.69 9.1 7.3 1.5 1 0 0 1 1 1 0 Sporulation factor SpoIIGA FucT_N PF18025.1 EKE38818.1 - 0.04 14.4 0.3 2 8.9 0.2 2.6 2 0 0 2 2 2 0 Alpha-(1,3)-fucosyltransferase FucT N-terminal domain PBP_dimer PF03717.15 EKE38820.1 - 0.093 13.1 1.4 0.15 12.4 1.4 1.3 1 0 0 1 1 1 0 Penicillin-binding Protein dimerisation domain RdRP PF05183.12 EKE38821.1 - 9.3e-06 24.6 0.1 1.8e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF5388 PF17363.2 EKE38821.1 - 0.026 14.7 0.0 0.093 12.9 0.0 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5388) RNase_P_p30 PF01876.16 EKE38822.1 - 7.4e-35 120.4 0.1 1.2e-34 119.7 0.1 1.4 1 0 0 1 1 1 1 RNase P subunit p30 Oxysterol_BP PF01237.18 EKE38822.1 - 1.1e-06 27.8 1.8 8.6e-05 21.5 1.8 2.2 1 1 0 1 1 1 1 Oxysterol-binding protein K-box PF01486.17 EKE38822.1 - 0.0032 17.6 0.8 0.0032 17.6 0.8 1.9 2 0 0 2 2 2 1 K-box region V-ATPase_G PF03179.15 EKE38823.1 - 1.6e-18 67.2 22.0 1.7e-18 67.1 22.0 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Apolipoprotein PF01442.18 EKE38823.1 - 0.015 15.2 13.7 0.016 15.1 13.7 1.0 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Cupin_8 PF13621.6 EKE38823.1 - 0.044 13.5 6.0 0.053 13.2 6.0 1.0 1 0 0 1 1 1 0 Cupin-like domain PIN_8 PF18476.1 EKE38823.1 - 0.14 12.0 9.8 0.17 11.7 9.8 1.2 1 0 0 1 1 1 0 PIN like domain FNIP_M PF14637.6 EKE38823.1 - 0.24 11.4 3.9 0.31 11.0 2.9 1.6 1 1 1 2 2 2 0 Folliculin-interacting protein middle domain PilJ PF13675.6 EKE38823.1 - 0.29 11.1 5.3 0.59 10.2 5.3 1.5 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term VitK2_biosynth PF02621.14 EKE38823.1 - 0.33 10.4 3.5 0.36 10.3 3.5 1.2 1 0 0 1 1 1 0 Menaquinone biosynthesis FAM60A PF15396.6 EKE38823.1 - 0.34 10.9 8.9 0.39 10.7 8.9 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Muted PF14942.6 EKE38823.1 - 0.43 10.9 17.0 0.58 10.5 17.0 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF1640 PF07798.11 EKE38823.1 - 0.49 10.4 14.3 0.54 10.3 14.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) TFIIE_alpha PF02002.17 EKE38823.1 - 0.51 10.2 7.8 1.2 9.1 7.4 1.8 1 1 0 1 1 1 0 TFIIE alpha subunit V-ATPase_G_2 PF16999.5 EKE38823.1 - 0.53 10.7 21.0 0.97 9.9 21.0 1.4 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Cytochrome_C554 PF13435.6 EKE38823.1 - 2.2 9.3 6.5 2.7 9.0 6.1 1.4 1 1 0 1 1 1 0 Cytochrome c554 and c-prime Zip PF02535.22 EKE38823.1 - 2.2 7.4 4.5 2.6 7.2 4.5 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF883 PF05957.13 EKE38823.1 - 5.3 7.7 11.4 5.5 7.7 5.3 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) WD40 PF00400.32 EKE38824.1 - 0.012 16.5 0.1 18 6.4 0.0 3.5 3 1 0 3 3 3 0 WD domain, G-beta repeat DUF3514 PF12027.8 EKE38824.1 - 0.067 12.9 0.2 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3514) Adap_comp_sub PF00928.21 EKE38825.1 - 0.0031 16.9 1.1 0.0061 16.0 1.1 1.6 1 1 0 1 1 1 1 Adaptor complexes medium subunit family DUF16 PF01519.16 EKE38826.1 - 0.00044 20.7 0.8 0.00055 20.4 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF16 GAS PF13851.6 EKE38826.1 - 0.003 16.9 0.3 0.004 16.5 0.3 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding ZapB PF06005.12 EKE38826.1 - 0.0037 17.7 0.9 0.005 17.3 0.9 1.1 1 0 0 1 1 1 1 Cell division protein ZapB AAA_13 PF13166.6 EKE38826.1 - 0.0041 15.9 0.5 0.0049 15.6 0.5 1.0 1 0 0 1 1 1 1 AAA domain GP41 PF00517.17 EKE38826.1 - 0.0042 17.0 0.2 0.0066 16.4 0.1 1.4 1 1 0 1 1 1 1 Retroviral envelope protein DUF724 PF05266.14 EKE38826.1 - 0.0048 16.8 0.7 0.0055 16.5 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF724) CENP-Q PF13094.6 EKE38826.1 - 0.0055 16.9 0.5 0.0086 16.3 0.5 1.3 1 1 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit COG2 PF06148.11 EKE38826.1 - 0.006 16.7 0.2 0.0077 16.3 0.2 1.1 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 BLOC1_2 PF10046.9 EKE38826.1 - 0.0088 16.3 2.1 0.012 15.9 2.1 1.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin_2 PF01920.20 EKE38826.1 - 0.0089 16.0 1.9 0.015 15.3 1.0 1.7 1 1 1 2 2 2 1 Prefoldin subunit HBM PF16591.5 EKE38826.1 - 0.011 15.1 0.2 0.013 14.9 0.2 1.0 1 0 0 1 1 1 0 Helical bimodular sensor domain Noelin-1 PF12308.8 EKE38826.1 - 0.013 15.5 0.7 0.016 15.2 0.7 1.1 1 0 0 1 1 1 0 Neurogenesis glycoprotein Snapin_Pallidin PF14712.6 EKE38826.1 - 0.016 15.6 0.8 0.021 15.3 0.8 1.1 1 0 0 1 1 1 0 Snapin/Pallidin ATG16 PF08614.11 EKE38826.1 - 0.021 15.0 1.9 0.028 14.7 1.9 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) TMEM191C PF15194.6 EKE38826.1 - 0.022 14.9 0.0 0.11 12.6 0.0 1.9 1 1 1 2 2 2 0 TMEM191C family DUF2207 PF09972.9 EKE38826.1 - 0.023 13.5 0.1 0.023 13.5 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CCCAP PF15964.5 EKE38826.1 - 0.025 12.9 0.0 0.029 12.7 0.0 1.0 1 0 0 1 1 1 0 Centrosomal colon cancer autoantigen protein family Use1 PF09753.9 EKE38826.1 - 0.026 14.3 0.1 0.028 14.2 0.1 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 COG6 PF06419.11 EKE38826.1 - 0.026 12.7 0.4 0.03 12.6 0.4 1.0 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 TTRAP PF14203.6 EKE38826.1 - 0.027 14.4 0.4 0.088 12.8 0.1 1.8 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein IL6 PF00489.17 EKE38826.1 - 0.034 13.7 0.2 0.04 13.5 0.2 1.1 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family YvrJ PF12841.7 EKE38826.1 - 0.035 13.6 0.5 2 8.0 0.1 2.4 2 0 0 2 2 2 0 YvrJ protein family CLZ PF16526.5 EKE38826.1 - 0.036 14.4 3.0 0.11 12.9 3.0 1.7 1 1 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Spc7 PF08317.11 EKE38826.1 - 0.044 12.7 1.0 0.05 12.5 1.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Laminin_II PF06009.12 EKE38826.1 - 0.049 13.6 1.0 0.061 13.3 1.0 1.1 1 0 0 1 1 1 0 Laminin Domain II SlyX PF04102.12 EKE38826.1 - 0.056 14.1 1.2 0.13 12.9 1.1 1.6 1 1 0 1 1 1 0 SlyX FmiP_Thoc5 PF09766.9 EKE38826.1 - 0.056 12.7 0.2 0.065 12.5 0.2 1.0 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 TMPIT PF07851.13 EKE38826.1 - 0.064 12.5 0.0 0.069 12.4 0.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein Lipoprotein_20 PF13942.6 EKE38826.1 - 0.065 13.1 0.7 0.084 12.8 0.7 1.2 1 0 0 1 1 1 0 YfhG lipoprotein NPV_P10 PF05531.12 EKE38826.1 - 0.07 13.6 1.2 0.21 12.1 1.1 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein TolA_bind_tri PF16331.5 EKE38826.1 - 0.074 13.1 1.5 0.093 12.8 1.5 1.1 1 0 0 1 1 1 0 TolA binding protein trimerisation DUF3450 PF11932.8 EKE38826.1 - 0.099 11.9 1.2 0.12 11.6 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Atg14 PF10186.9 EKE38826.1 - 0.13 11.4 0.2 0.15 11.1 0.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4349 PF14257.6 EKE38826.1 - 0.23 10.9 1.2 0.59 9.5 1.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4349) CorA PF01544.18 EKE38826.1 - 0.96 8.7 7.6 0.063 12.6 0.4 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Synaptobrevin PF00957.21 EKE38826.1 - 2.3 8.1 5.9 11 5.9 5.7 2.1 1 1 0 1 1 1 0 Synaptobrevin Lactamase_B PF00753.27 EKE38827.1 - 0.00038 20.5 0.0 0.0011 19.0 0.0 1.8 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.6 EKE38827.1 - 0.02 14.8 0.1 0.068 13.1 0.0 2.1 2 1 0 2 2 2 0 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EKE38827.1 - 0.042 13.4 0.0 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 Beta-lactamase superfamily domain MBOAT PF03062.19 EKE38828.1 - 1.9e-32 113.0 28.9 1.9e-32 113.0 28.9 2.2 1 1 2 3 3 3 1 MBOAT, membrane-bound O-acyltransferase family Pkinase PF00069.25 EKE38830.1 - 6e-15 55.3 0.6 7.6e-15 55.0 0.6 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38830.1 - 1.2e-13 51.0 0.1 1.2e-13 51.0 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EKE38830.1 - 0.015 14.6 0.0 0.017 14.5 0.0 1.0 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKE38830.1 - 0.087 11.6 0.2 0.092 11.5 0.2 1.1 1 0 0 1 1 1 0 Fungal protein kinase RasGEF PF00617.19 EKE38832.1 - 2.5e-35 122.3 3.7 6.3e-35 121.0 3.7 1.7 1 0 0 1 1 1 1 RasGEF domain RhoGAP PF00620.27 EKE38832.1 - 0.00091 19.1 0.2 0.0065 16.3 0.1 2.4 2 0 0 2 2 2 1 RhoGAP domain SelP_N PF04592.14 EKE38833.1 - 0.0038 16.7 4.6 0.0044 16.5 4.6 1.1 1 0 0 1 1 1 1 Selenoprotein P, N terminal region FRG1 PF06229.12 EKE38833.1 - 0.13 12.0 6.8 0.11 12.2 6.0 1.3 1 1 0 1 1 1 0 FRG1-like domain FancD2 PF14631.6 EKE38833.1 - 1.4 6.3 6.3 1.6 6.0 6.3 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Peptidase_S49_N PF08496.10 EKE38833.1 - 3 7.9 8.1 4.5 7.3 8.1 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF1764 PF08576.10 EKE38833.1 - 3.9 8.4 11.6 3.6 8.6 9.8 1.9 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Zip PF02535.22 EKE38833.1 - 8.4 5.5 6.8 9.9 5.3 6.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Connexin PF00029.19 EKE38833.1 - 9.1 6.0 5.8 11 5.6 5.8 1.2 1 0 0 1 1 1 0 Connexin HSP70 PF00012.20 EKE38834.1 - 0.05 11.8 0.0 0.055 11.7 0.0 1.0 1 0 0 1 1 1 0 Hsp70 protein HSP70 PF00012.20 EKE38835.1 - 2.1e-18 65.9 0.2 2.3e-18 65.7 0.2 1.0 1 0 0 1 1 1 1 Hsp70 protein StbA PF06406.11 EKE38835.1 - 0.0017 17.6 0.0 0.0017 17.6 0.0 1.1 1 0 0 1 1 1 1 StbA protein Vac_Fusion PF02346.16 EKE38837.1 - 1.6 8.4 13.5 3.4 7.4 2.7 3.9 3 2 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 DUF4487 PF14868.6 EKE38838.1 - 0.028 13.3 0.3 0.031 13.1 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) VPS9 PF02204.18 EKE38839.1 - 0.0016 18.6 1.0 0.0053 17.0 1.0 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain SepF PF04472.12 EKE38839.1 - 0.13 12.5 0.9 12 6.3 0.2 3.5 3 0 0 3 3 3 0 Cell division protein SepF Arm PF00514.23 EKE38841.1 - 0.11 12.6 0.0 0.11 12.6 0.0 3.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat MRP-S23 PF10484.9 EKE38843.1 - 0.17 12.2 2.4 0.24 11.7 0.8 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal protein S23 GTP_EFTU PF00009.27 EKE38844.1 - 2e-06 27.5 0.1 2.1e-06 27.4 0.1 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF5627 PF18620.1 EKE38844.1 - 0.17 11.7 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5627) MFS_1 PF07690.16 EKE38845.1 - 3.3e-27 95.3 22.1 2.4e-22 79.4 19.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Ninjurin PF04923.12 EKE38845.1 - 1.9 8.5 0.0 1.9 8.5 0.0 3.2 4 0 0 4 4 4 0 Ninjurin DUF4783 PF16022.5 EKE38846.1 - 0.037 14.2 1.8 0.15 12.2 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4783) SlyX PF04102.12 EKE38846.1 - 0.062 13.9 3.3 4.5 8.0 0.1 2.5 2 0 0 2 2 2 0 SlyX DUF2675 PF11247.8 EKE38846.1 - 0.076 13.2 0.4 0.4 10.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2675) Pyridox_ox_2 PF12900.7 EKE38848.1 - 2.3e-15 56.8 0.0 2.6e-15 56.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 EKE38848.1 - 0.00036 20.6 0.0 0.00055 20.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Spatacsin_C PF14649.6 EKE38849.1 - 1.6e-20 73.5 7.6 5.2e-20 71.8 2.1 2.6 2 0 0 2 2 2 2 Spatacsin C-terminus PP2C PF00481.21 EKE38849.1 - 0.082 12.5 0.0 0.26 10.9 0.0 1.8 1 0 0 1 1 1 0 Protein phosphatase 2C 5_3_exonuc PF01367.20 EKE38849.1 - 0.26 11.9 2.3 2.5 8.7 0.0 3.6 3 0 0 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold Mad3_BUB1_I PF08311.12 EKE38849.1 - 0.29 11.1 6.7 0.67 9.9 0.2 4.3 3 1 0 4 4 4 0 Mad3/BUB1 homology region 1 Dpoe2NT PF12213.8 EKE38849.1 - 1.6 9.1 4.6 16 5.9 0.2 3.4 3 0 0 3 3 3 0 DNA polymerases epsilon N terminal Syja_N PF02383.18 EKE38850.1 - 7.2e-80 268.7 6.0 1.1e-79 268.0 6.0 1.3 1 0 0 1 1 1 1 SacI homology domain Sigma70_ner PF04546.13 EKE38850.1 - 0.00054 19.9 2.6 0.0011 18.9 2.6 1.5 1 0 0 1 1 1 1 Sigma-70, non-essential region MULE PF10551.9 EKE38850.1 - 0.091 13.2 0.5 19 5.7 0.3 3.3 2 1 1 3 3 3 0 MULE transposase domain AMP-binding PF00501.28 EKE38851.1 - 1.4e-46 159.0 0.0 2.3e-46 158.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EKE38851.1 - 2.9e-29 102.0 0.0 4.5e-29 101.4 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EKE38851.1 - 6e-07 29.7 0.0 1.7e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EKE38851.1 - 5.2e-06 25.7 0.4 1e-05 24.7 0.4 1.5 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EKE38851.1 - 8.2e-06 25.5 0.0 1.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family BORCS7 PF16088.5 EKE38851.1 - 0.0065 16.7 2.0 0.035 14.4 2.0 2.3 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 7 RmlD_sub_bind PF04321.17 EKE38851.1 - 0.12 11.4 0.0 0.51 9.4 0.0 1.8 2 0 0 2 2 2 0 RmlD substrate binding domain MLD PF11647.8 EKE38851.1 - 0.14 12.5 0.6 18 5.7 0.0 2.8 2 0 0 2 2 2 0 Membrane Localization Domain Met_10 PF02475.16 EKE38852.1 - 0.021 14.5 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_25 PF13649.6 EKE38852.1 - 0.035 14.8 0.0 0.076 13.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EKE38852.1 - 0.08 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 EKE38852.1 - 0.13 11.2 0.1 0.19 10.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) RRM_1 PF00076.22 EKE38853.1 - 7.7e-30 102.5 0.7 1.9e-14 53.2 0.2 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKE38853.1 - 0.00077 19.1 1.0 0.34 10.5 0.2 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 EKE38853.1 - 0.0016 18.4 0.3 0.0034 17.3 0.3 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 EKE38853.1 - 0.007 16.4 0.1 3.5 7.7 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 EKE38853.1 - 0.13 12.4 0.4 2.9 8.0 0.1 2.3 2 0 0 2 2 2 0 Limkain b1 PHM7_cyt PF14703.6 EKE38853.1 - 0.14 12.4 0.0 1.4 9.1 0.0 2.1 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter SNF2_N PF00176.23 EKE38854.1 - 2e-28 99.2 0.1 4.1e-28 98.1 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE38854.1 - 6.1e-12 45.9 0.5 3.5e-10 40.2 0.1 3.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE38854.1 - 2e-11 44.2 5.6 2e-09 37.7 0.0 4.0 3 1 1 4 4 4 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EKE38854.1 - 0.0022 18.0 0.0 0.87 9.6 0.0 2.6 2 0 0 2 2 2 2 Flavivirus DEAD domain TIG_plexin PF17960.1 EKE38855.1 - 0.39 10.8 3.9 0.27 11.2 1.7 1.8 2 0 0 2 2 2 0 TIG domain DUF5566 PF17721.1 EKE38855.1 - 1.1 9.5 5.7 0.35 11.1 2.0 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5566) FYVE_2 PF02318.16 EKE38855.1 - 1.8 8.8 6.2 1.5 9.0 2.5 2.1 2 0 0 2 2 2 0 FYVE-type zinc finger T4-Gluco-transf PF09198.10 EKE38856.1 - 0.22 11.2 2.9 0.42 10.3 0.2 2.7 2 1 0 2 2 2 0 Bacteriophage T4 beta-glucosyltransferase RRM_1 PF00076.22 EKE38857.1 - 4.6e-36 122.5 0.4 1.7e-18 66.2 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EKE38857.1 - 0.011 15.8 0.0 0.087 13.0 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif RRM_8 PF11835.8 EKE38857.1 - 0.015 15.5 0.0 0.5 10.6 0.0 2.2 2 0 0 2 2 2 0 RRM-like domain Nup35_RRM_2 PF14605.6 EKE38857.1 - 0.036 14.0 0.6 5.3 7.1 0.1 2.6 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif MIG-14_Wnt-bd PF06664.12 EKE38858.1 - 2e-31 109.3 49.7 2e-31 109.3 49.7 1.8 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion DUF5392 PF17370.2 EKE38858.1 - 0.054 13.6 0.5 0.054 13.6 0.5 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5392) hNIFK_binding PF12196.8 EKE38858.1 - 0.44 10.1 2.1 1.1 8.8 0.9 2.1 2 0 0 2 2 2 0 FHA Ki67 binding domain of hNIFK SET PF00856.28 EKE38859.1 - 4.4e-11 43.4 7.1 8.8e-11 42.5 4.3 2.5 2 1 0 2 2 2 1 SET domain TPR_2 PF07719.17 EKE38859.1 - 7.6e-09 35.0 0.9 0.00086 19.2 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EKE38859.1 - 2.7e-08 33.3 2.7 0.0049 16.6 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKE38859.1 - 7.1e-07 29.0 2.0 0.027 14.7 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EKE38859.1 - 0.00046 20.4 0.0 0.0017 18.6 0.0 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 EKE38859.1 - 0.0063 17.0 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE38859.1 - 0.01 16.1 0.6 0.078 13.2 0.7 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EKE38859.1 - 0.019 15.0 0.0 1.7 8.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EKE38859.1 - 0.022 14.4 1.1 0.13 12.0 0.1 2.3 2 0 0 2 2 2 0 TPR repeat TPR_18 PF13512.6 EKE38859.1 - 0.024 14.7 0.7 0.049 13.8 0.7 1.5 1 1 0 1 1 1 0 Tetratricopeptide repeat YfiO PF13525.6 EKE38859.1 - 0.026 14.3 1.1 0.037 13.8 1.1 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein TPR_6 PF13174.6 EKE38859.1 - 0.026 15.1 0.0 15 6.4 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 EKE38859.1 - 0.12 12.5 5.2 11 6.1 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EKE38859.1 - 0.12 13.3 0.0 15 6.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.20 EKE38859.1 - 0.66 10.4 5.3 0.56 10.6 0.5 3.2 4 0 0 4 4 4 0 PPR repeat GM_CSF PF01109.17 EKE38860.1 - 0.027 14.6 0.5 0.064 13.4 0.5 1.6 1 0 0 1 1 1 0 Granulocyte-macrophage colony-stimulating factor ATP_bind_1 PF03029.17 EKE38861.1 - 8.9e-65 218.8 0.2 8.9e-65 218.8 0.2 1.4 2 0 0 2 2 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EKE38861.1 - 1.7e-06 28.1 0.1 4.5e-05 23.5 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE38861.1 - 2.5e-05 23.9 6.2 0.0003 20.4 0.0 2.7 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE38861.1 - 0.00011 22.2 0.9 0.49 10.3 0.0 3.1 2 2 0 2 2 2 2 RsgA GTPase AAA_33 PF13671.6 EKE38861.1 - 0.00016 21.9 0.1 0.00016 21.9 0.1 2.3 2 1 0 2 2 2 1 AAA domain AIG1 PF04548.16 EKE38861.1 - 0.00019 20.8 7.1 0.00064 19.1 0.1 3.0 3 0 0 3 3 3 1 AIG1 family AAA_18 PF13238.6 EKE38861.1 - 0.00083 19.9 0.8 0.0023 18.4 0.0 2.1 2 1 1 3 3 2 1 AAA domain FeoB_N PF02421.18 EKE38861.1 - 0.0011 18.5 0.4 0.27 10.8 0.1 2.5 2 0 0 2 2 2 1 Ferrous iron transport protein B NB-ARC PF00931.22 EKE38861.1 - 0.0033 16.7 0.4 0.0033 16.7 0.4 1.8 2 1 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 EKE38861.1 - 0.0044 17.4 0.0 0.033 14.6 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EKE38861.1 - 0.0055 17.1 0.2 0.047 14.1 0.0 2.4 2 1 1 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EKE38861.1 - 0.0075 16.0 0.2 0.026 14.3 0.1 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EKE38861.1 - 0.0076 16.0 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EKE38861.1 - 0.011 16.3 0.4 0.039 14.5 0.0 2.0 2 0 0 2 2 2 0 ABC transporter cobW PF02492.19 EKE38861.1 - 0.012 15.2 1.0 0.12 11.9 0.1 2.3 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Gtr1_RagA PF04670.12 EKE38861.1 - 0.013 14.8 0.7 0.013 14.8 0.7 2.2 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region SRP54 PF00448.22 EKE38861.1 - 0.013 15.1 0.1 0.099 12.3 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_22 PF13401.6 EKE38861.1 - 0.02 15.1 0.0 0.23 11.7 0.0 2.5 2 1 1 3 3 3 0 AAA domain PduV-EutP PF10662.9 EKE38861.1 - 0.021 14.6 1.4 0.25 11.1 0.1 2.8 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EKE38861.1 - 0.029 14.3 0.1 0.059 13.3 0.1 1.4 1 0 0 1 1 1 0 NACHT domain Thioredoxin_2 PF13098.6 EKE38861.1 - 0.05 14.0 1.4 0.41 11.1 0.0 2.8 3 0 0 3 3 3 0 Thioredoxin-like domain AAA_14 PF13173.6 EKE38861.1 - 0.06 13.4 0.4 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Thioredoxin_7 PF13899.6 EKE38861.1 - 0.062 13.5 0.5 0.13 12.4 0.0 1.8 2 0 0 2 2 1 0 Thioredoxin-like Arf PF00025.21 EKE38861.1 - 0.069 12.6 1.3 0.12 11.8 0.1 2.1 2 1 0 2 2 2 0 ADP-ribosylation factor family RNA_helicase PF00910.22 EKE38861.1 - 0.079 13.4 0.5 3.3 8.1 0.0 3.2 3 0 0 3 3 3 0 RNA helicase NTPase_1 PF03266.15 EKE38861.1 - 0.083 12.8 0.9 1.9 8.4 0.0 2.7 3 0 0 3 3 3 0 NTPase AAA_5 PF07728.14 EKE38861.1 - 0.084 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 EKE38861.1 - 0.1 13.0 1.1 0.62 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EKE38861.1 - 0.13 12.3 0.7 1.9 8.5 0.0 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_28 PF13521.6 EKE38861.1 - 0.15 12.3 0.9 0.44 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EKE38861.1 - 0.22 11.6 4.3 4.3 7.4 0.0 3.1 3 0 0 3 3 3 0 Dynamin family SRPRB PF09439.10 EKE38861.1 - 0.25 10.8 0.1 0.25 10.8 0.1 2.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Roc PF08477.13 EKE38861.1 - 0.43 10.8 4.5 2.3 8.5 0.0 2.9 3 1 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 EKE38861.1 - 1.4 8.1 5.8 0.26 10.5 0.2 2.5 2 1 0 2 2 2 0 Septin dNK PF01712.19 EKE38861.1 - 1.8 8.4 5.7 0.88 9.4 0.1 2.7 2 2 0 2 2 2 0 Deoxynucleoside kinase Clat_adaptor_s PF01217.20 EKE38862.1 - 8e-16 58.3 0.4 8.7e-16 58.1 0.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Myb_DNA-binding PF00249.31 EKE38863.1 - 2e-29 101.5 0.8 2.2e-17 62.9 0.2 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE38863.1 - 1.4e-24 86.1 0.4 4.7e-15 55.6 0.2 2.1 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EKE38863.1 - 2e-09 37.2 0.4 5.3e-06 26.2 0.4 2.1 1 1 1 2 2 2 2 Myb DNA-binding like SLIDE PF09111.10 EKE38863.1 - 1.6e-05 24.9 0.5 0.015 15.3 0.0 2.2 1 1 1 2 2 2 2 SLIDE TnsD PF15978.5 EKE38863.1 - 0.0007 18.7 3.0 0.15 11.0 0.0 2.1 2 0 0 2 2 2 2 Tn7-like transposition protein D Myb_DNA-bind_2 PF08914.11 EKE38863.1 - 0.0071 16.5 0.6 0.26 11.5 0.0 2.7 1 1 1 2 2 2 1 Rap1 Myb domain DUF4085 PF13315.6 EKE38863.1 - 0.012 15.2 0.3 0.022 14.4 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4085) IRK_N PF08466.10 EKE38863.1 - 0.044 13.9 0.0 0.089 13.0 0.0 1.6 1 0 0 1 1 1 0 Inward rectifier potassium channel N-terminal DUF3703 PF12487.8 EKE38863.1 - 0.054 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3703) DUF2508 PF10704.9 EKE38863.1 - 0.084 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) DUP PF00674.18 EKE38863.1 - 0.092 12.9 2.0 0.54 10.4 0.2 2.3 2 0 0 2 2 2 0 DUP family SANT_DAMP1_like PF16282.5 EKE38863.1 - 0.16 12.2 0.9 0.56 10.4 0.1 2.0 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 HHH_2 PF12826.7 EKE38864.1 - 0.018 15.1 1.5 0.22 11.6 0.0 2.9 3 0 0 3 3 3 0 Helix-hairpin-helix motif RabGAP-TBC PF00566.18 EKE38865.1 - 2.3e-35 122.2 5.9 3.6e-35 121.6 5.9 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4300 PF14133.6 EKE38865.1 - 0.024 14.4 0.2 0.035 13.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4300) OSR1_C PF12202.8 EKE38866.1 - 0.028 14.6 0.2 0.071 13.3 0.0 1.7 2 0 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain PI3_PI4_kinase PF00454.27 EKE38867.1 - 4.3e-41 141.4 0.0 6.5e-39 134.2 0.0 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EKE38867.1 - 1.1e-13 51.1 0.0 2.3e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EKE38867.1 - 6.1e-05 22.5 0.0 0.0001 21.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) PI3K_C2 PF00792.24 EKE38867.1 - 0.00013 21.9 0.0 0.00041 20.3 0.0 1.9 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 SHQ1 PF04925.15 EKE38868.1 - 4.1e-40 137.2 2.1 4.1e-40 137.2 2.1 1.9 2 0 0 2 2 2 1 SHQ1 protein Arm_3 PF16186.5 EKE38868.1 - 0.054 13.1 2.5 0.07 12.7 0.2 2.5 2 0 0 2 2 2 0 Atypical Arm repeat ubiquitin PF00240.23 EKE38869.1 - 0.02 14.6 0.1 0.16 11.8 0.1 2.4 1 1 0 1 1 1 0 Ubiquitin family Receptor_IA-2 PF11548.8 EKE38869.1 - 0.095 12.7 1.3 12 6.0 0.0 2.8 2 1 1 3 3 3 0 Protein-tyrosine phosphatase receptor IA-2 SPRY PF00622.28 EKE38871.1 - 5.9e-05 23.2 0.1 0.00012 22.1 0.1 1.5 1 0 0 1 1 1 1 SPRY domain BTB_2 PF02214.22 EKE38871.1 - 0.00017 21.9 0.6 0.00051 20.3 0.6 1.9 1 0 0 1 1 1 1 BTB/POZ domain NAPRTase_C PF17956.1 EKE38871.1 - 0.52 10.8 6.5 0.23 11.9 0.9 2.9 2 1 1 3 3 3 0 Nicotinate phosphoribosyltransferase C-terminal domain Lipase_3 PF01764.25 EKE38872.1 - 2.5e-08 33.9 0.0 5.3e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) RIFIN PF02009.16 EKE38872.1 - 8.6e-05 22.6 1.4 0.00027 21.0 1.4 1.8 1 0 0 1 1 1 1 Rifin DUF4731 PF15875.5 EKE38872.1 - 0.00044 20.4 0.7 0.57 10.4 0.0 3.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4731) Connexin PF00029.19 EKE38872.1 - 0.019 14.7 6.2 0.058 13.2 6.3 1.8 1 1 0 1 1 1 0 Connexin DUF2370 PF10176.9 EKE38872.1 - 0.032 13.9 0.3 0.068 12.8 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) LRRC37AB_C PF14914.6 EKE38872.1 - 0.032 14.1 7.1 0.078 12.9 7.1 1.6 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain LAP1C PF05609.12 EKE38872.1 - 0.032 13.3 2.6 0.051 12.7 2.6 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Hydrolase_4 PF12146.8 EKE38872.1 - 0.038 13.2 0.0 0.084 12.1 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 EOS1 PF12326.8 EKE38872.1 - 0.041 13.8 0.1 0.075 13.0 0.1 1.5 1 0 0 1 1 1 0 N-glycosylation protein DUF3464 PF11947.8 EKE38872.1 - 0.043 13.6 0.5 0.1 12.3 0.5 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PGAP1 PF07819.13 EKE38872.1 - 0.052 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Zip PF02535.22 EKE38872.1 - 0.057 12.6 0.4 0.15 11.2 0.0 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter DDHD PF02862.17 EKE38872.1 - 0.076 13.2 0.5 0.12 12.6 0.5 1.3 1 0 0 1 1 1 0 DDHD domain DUF4834 PF16118.5 EKE38872.1 - 0.12 13.3 13.2 0.92 10.5 0.6 3.1 3 0 0 3 3 2 0 Domain of unknown function (DUF4834) Peptidase_M56 PF05569.11 EKE38872.1 - 0.13 11.5 3.8 0.17 11.1 1.1 2.2 1 1 1 2 2 2 0 BlaR1 peptidase M56 MatE PF01554.18 EKE38872.1 - 1.5 8.5 19.4 0.61 9.7 0.9 3.8 3 1 1 4 4 4 0 MatE Ctr PF04145.15 EKE38872.1 - 3.1 8.4 5.8 8.2 7.0 5.8 1.9 1 1 0 1 1 1 0 Ctr copper transporter family CrgA PF06781.12 EKE38872.1 - 3.9 7.6 5.8 1.2 9.3 0.1 2.8 2 1 1 3 3 3 0 Cell division protein CrgA Met_10 PF02475.16 EKE38874.1 - 4.5e-54 183.2 4.0 6.1e-54 182.8 0.3 2.1 2 0 0 2 2 2 1 Met-10+ like-protein TRM PF02005.16 EKE38874.1 - 0.00051 19.3 0.0 0.0011 18.2 0.0 1.5 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase PrmA PF06325.13 EKE38874.1 - 0.014 14.8 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 EKE38874.1 - 0.048 13.2 0.0 0.17 11.5 0.0 1.9 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 EKE38874.1 - 0.078 13.7 0.0 0.25 12.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 EKE38874.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_11 PF08241.12 EKE38874.1 - 0.1 13.2 0.0 0.36 11.5 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain SYS1 PF09801.9 EKE38875.1 - 0.00013 22.2 0.2 0.00015 21.9 0.2 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network NQR2_RnfD_RnfE PF03116.15 EKE38875.1 - 0.027 13.9 0.1 0.027 13.9 0.1 1.0 1 0 0 1 1 1 0 NQR2, RnfD, RnfE family Pkinase PF00069.25 EKE38876.1 - 1.4e-58 198.3 0.1 1.7e-58 198.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38876.1 - 1e-37 129.9 0.0 1.2e-37 129.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE38876.1 - 1.5e-06 27.7 0.0 1.9e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EKE38876.1 - 0.00016 20.7 0.6 0.00031 19.8 0.6 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EKE38876.1 - 0.00025 20.7 0.3 0.00036 20.2 0.3 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EKE38876.1 - 0.0017 17.7 1.0 0.0026 17.2 1.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EKE38876.1 - 0.009 16.0 0.2 0.013 15.5 0.2 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EKE38876.1 - 0.016 14.0 0.8 0.2 10.4 0.6 2.1 1 1 1 2 2 2 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EKE38876.1 - 0.076 12.5 0.1 0.19 11.2 0.1 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Ras PF00071.22 EKE38877.1 - 1.6e-11 44.1 0.0 2.4e-11 43.5 0.0 1.3 1 1 0 1 1 1 1 Ras family Arf PF00025.21 EKE38877.1 - 7.3e-05 22.3 0.0 9.2e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EKE38877.1 - 0.00014 22.1 0.0 0.0014 18.8 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EKE38877.1 - 0.00035 19.9 0.1 0.27 10.4 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit RsgA_GTPase PF03193.16 EKE38877.1 - 0.0012 18.8 0.2 0.33 10.9 0.0 2.6 1 1 2 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE38877.1 - 0.0024 17.9 0.0 0.006 16.6 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKE38877.1 - 0.032 13.8 0.1 6.4 6.3 0.0 2.4 2 1 0 2 2 2 0 Ferrous iron transport protein B Peptidase_S24 PF00717.23 EKE38877.1 - 0.15 12.1 0.2 3.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Peptidase S24-like ALS_ss_C PF10369.9 EKE38878.1 - 0.067 13.4 0.1 1.1 9.5 0.0 2.9 2 0 0 2 2 2 0 Small subunit of acetolactate synthase Occludin_ELL PF07303.13 EKE38878.1 - 2.1 9.1 12.7 3.1 8.6 3.5 4.9 4 0 0 4 4 4 0 Occludin homology domain TPR_3 PF07720.12 EKE38878.1 - 2.7 8.1 4.9 1.6 8.8 1.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ATP_bind_3 PF01171.20 EKE38879.1 - 8.9e-18 64.7 0.0 1.3e-17 64.2 0.0 1.2 1 0 0 1 1 1 1 PP-loop family Diphthami_syn_2 PF01902.17 EKE38879.1 - 0.0051 16.3 0.0 0.0077 15.8 0.0 1.5 1 1 0 1 1 1 1 Diphthamide synthase NAD_synthase PF02540.17 EKE38879.1 - 0.0084 15.2 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 NAD synthase tRNA_Me_trans PF03054.16 EKE38879.1 - 0.015 14.1 0.0 0.025 13.4 0.0 1.3 1 1 0 1 1 1 0 tRNA methyl transferase QueH PF02677.14 EKE38879.1 - 0.02 15.0 0.3 0.74 9.9 0.0 2.2 1 1 1 2 2 2 0 Epoxyqueuosine reductase QueH Csm1_N PF18504.1 EKE38880.1 - 0.0029 17.9 0.6 0.028 14.8 0.1 2.5 1 1 1 2 2 2 1 Csm1 N-terminal domain IF2_N PF04760.15 EKE38880.1 - 0.0042 16.9 0.7 4.3 7.2 0.0 3.0 3 0 0 3 3 3 2 Translation initiation factor IF-2, N-terminal region DUF2508 PF10704.9 EKE38880.1 - 0.011 15.9 7.4 0.052 13.7 1.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2508) Fes1 PF08609.10 EKE38880.1 - 0.032 15.1 4.6 2.6 9.0 0.8 2.6 2 1 0 2 2 2 0 Nucleotide exchange factor Fes1 CNF1 PF05785.12 EKE38880.1 - 0.1 11.8 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Rho-activating domain of cytotoxic necrotizing factor RabGAP-TBC PF00566.18 EKE38883.1 - 8.4e-11 41.9 0.4 1.2e-10 41.5 0.4 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Glyco_hydro_92 PF07971.12 EKE38885.1 - 5.8e-119 398.0 6.5 7.6e-119 397.6 6.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EKE38885.1 - 3.5e-10 40.2 0.0 3e-09 37.1 0.0 2.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain BOP1NT PF08145.12 EKE38886.1 - 4.3e-38 131.7 11.9 2.6e-36 125.9 11.9 2.3 1 1 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EKE38886.1 - 3.6e-11 43.4 4.7 0.012 16.5 0.0 4.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE38886.1 - 0.021 15.1 0.0 2.3 8.6 0.0 3.2 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Ank_2 PF12796.7 EKE38887.1 - 0.00032 21.2 0.2 0.04 14.5 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE38887.1 - 0.0014 19.2 0.0 0.011 16.3 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE38887.1 - 0.067 13.8 0.0 0.68 10.7 0.0 2.8 1 0 0 1 1 1 0 Ankyrin repeat Ank PF00023.30 EKE38887.1 - 0.12 12.9 0.0 0.44 11.1 0.0 2.0 1 0 0 1 1 1 0 Ankyrin repeat LSM PF01423.22 EKE38889.1 - 2.8e-17 62.2 0.4 3.7e-17 61.8 0.4 1.2 1 0 0 1 1 1 1 LSM domain Kringle PF00051.18 EKE38889.1 - 0.049 13.9 0.2 0.12 12.7 0.1 1.7 1 1 1 2 2 2 0 Kringle domain SM-ATX PF14438.6 EKE38889.1 - 0.073 13.2 1.8 0.084 13.0 0.1 1.9 2 1 0 2 2 2 0 Ataxin 2 SM domain DnaJ_C PF01556.18 EKE38890.1 - 3.4e-30 105.1 0.5 4.8e-30 104.6 0.5 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EKE38890.1 - 1.9e-28 98.4 4.4 4e-28 97.3 4.4 1.6 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 EKE38890.1 - 0.099 12.6 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 A repeated domain in UCH-protein Rtt106 PF08512.12 EKE38890.1 - 0.27 11.7 2.7 6.9 7.2 0.2 2.6 2 1 0 2 2 2 0 Histone chaperone Rttp106-like YL1 PF05764.13 EKE38891.1 - 0.61 10.2 12.1 0.66 10.1 12.1 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Mpp10 PF04006.12 EKE38891.1 - 2.5 6.5 17.7 2.8 6.3 17.7 1.0 1 0 0 1 1 1 0 Mpp10 protein RNA_polI_A14 PF08203.11 EKE38892.1 - 0.84 10.4 4.5 2.5 8.9 4.5 1.8 1 1 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 HSP70 PF00012.20 EKE38893.1 - 1.9e-63 214.7 1.6 2.2e-63 214.4 1.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE38893.1 - 1.9e-16 59.8 0.1 6.3e-16 58.1 0.0 1.9 2 1 0 2 2 2 1 MreB/Mbl protein StbA PF06406.11 EKE38893.1 - 0.0022 17.3 0.0 0.2 10.8 0.0 2.5 2 0 0 2 2 2 1 StbA protein DMRL_synthase PF00885.19 EKE38893.1 - 0.025 14.4 0.1 5.7 6.8 0.0 3.1 2 1 0 2 2 2 0 6,7-dimethyl-8-ribityllumazine synthase SrfB PF07520.11 EKE38893.1 - 0.058 11.3 0.7 1.2 6.9 0.2 2.8 3 1 1 4 4 4 0 Virulence factor SrfB ALP_N PF17989.1 EKE38893.1 - 0.14 12.3 0.3 27 4.9 0.0 3.2 3 0 0 3 3 3 0 Actin like proteins N terminal domain FGGY_C PF02782.16 EKE38893.1 - 0.2 11.4 0.0 0.5 10.0 0.0 1.6 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain DUF5104 PF17117.5 EKE38893.1 - 2.1 8.8 11.8 0.12 12.8 0.7 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF5104) Pkinase PF00069.25 EKE38895.1 - 5.7e-53 180.0 0.6 9.9e-53 179.2 0.6 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38895.1 - 2.5e-51 174.5 0.2 4.9e-51 173.5 0.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase VSP PF03302.13 EKE38895.1 - 3.7e-15 55.7 492.6 0.00021 20.3 20.6 16.5 1 1 12 14 14 14 9 Giardia variant-specific surface protein Pkinase_fungal PF17667.1 EKE38895.1 - 2.2e-07 30.0 0.1 3.4e-07 29.4 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase TMEM154 PF15102.6 EKE38895.1 - 0.00053 19.9 0.1 0.0014 18.5 0.1 1.7 1 0 0 1 1 1 1 TMEM154 protein family Kdo PF06293.14 EKE38895.1 - 0.0015 17.9 0.1 0.0026 17.2 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EphA2_TM PF14575.6 EKE38895.1 - 0.09 13.7 0.1 0.35 11.8 0.1 2.0 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ECSCR PF15820.5 EKE38895.1 - 0.14 12.0 4.9 0.14 12.0 0.5 3.2 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Baculo_11_kDa PF06143.11 EKE38895.1 - 1.2 8.8 3.9 3.1 7.5 3.9 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF5385 PF17359.2 EKE38895.1 - 1.4 8.4 6.8 0.38 10.3 1.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5385) Motile_Sperm PF00635.26 EKE38896.1 - 0.00034 20.4 0.1 0.00096 19.0 0.1 1.8 1 0 0 1 1 1 1 MSP (Major sperm protein) domain EGF_2 PF07974.13 EKE38896.1 - 0.026 14.9 5.9 0.026 14.9 5.9 2.5 2 1 1 3 3 3 0 EGF-like domain CHDCT2 PF08074.11 EKE38896.1 - 0.062 13.5 0.0 0.32 11.2 0.0 2.1 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain hEGF PF12661.7 EKE38896.1 - 0.26 12.0 9.8 0.095 13.4 5.8 2.6 2 0 0 2 2 2 0 Human growth factor-like EGF cEGF PF12662.7 EKE38896.1 - 0.68 9.9 10.0 0.095 12.7 4.9 2.3 2 0 0 2 2 2 0 Complement Clr-like EGF-like HTH_Tnp_1 PF01527.20 EKE38897.1 - 0.033 14.5 0.2 0.15 12.4 0.2 1.9 1 1 0 1 1 1 0 Transposase Ribosomal_L37e PF01907.19 EKE38899.1 - 2.4e-25 88.4 12.3 3.9e-25 87.8 12.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 EKE38899.1 - 0.0042 17.1 3.7 0.0055 16.7 3.7 1.2 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 EKE38899.1 - 0.049 13.6 2.4 0.059 13.4 2.4 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF4543 PF15076.6 EKE38899.1 - 0.056 13.6 0.1 0.067 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4543) DUF2688 PF10892.8 EKE38899.1 - 0.1 12.1 2.6 9.7 5.7 1.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) zinc_ribbon_6 PF14599.6 EKE38899.1 - 0.23 11.5 4.4 0.37 10.8 4.4 1.3 1 0 0 1 1 1 0 Zinc-ribbon zf-C3HC4_2 PF13923.6 EKE38899.1 - 0.44 10.4 4.6 0.71 9.8 4.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SERTA PF06031.13 EKE38900.1 - 0.61 9.8 4.6 1.4 8.6 0.1 3.0 3 0 0 3 3 3 0 SERTA motif SIR4_SID PF16991.5 EKE38901.1 - 0.0025 17.9 4.1 0.0052 16.9 4.1 1.6 1 0 0 1 1 1 1 Sir4 SID domain DnaJ_C PF01556.18 EKE38901.1 - 0.0027 17.8 0.0 0.042 13.9 0.0 2.3 1 1 0 1 1 1 1 DnaJ C terminal domain MCR_beta_N PF02783.15 EKE38901.1 - 0.036 13.7 0.1 0.057 13.0 0.1 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, N-terminal domain PH PF00169.29 EKE38902.1 - 0.0018 18.8 0.9 0.0018 18.8 0.9 1.8 1 1 1 2 2 2 1 PH domain PH_12 PF16457.5 EKE38902.1 - 0.0024 18.4 0.8 0.0064 17.0 0.0 1.9 1 1 1 2 2 2 1 Pleckstrin homology domain DUF2373 PF10180.9 EKE38902.1 - 0.059 13.2 1.9 0.059 13.2 1.9 2.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2373) adh_short PF00106.25 EKE38903.1 - 4.3e-27 94.8 0.1 4.1e-26 91.7 0.1 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EKE38903.1 - 2.2e-13 50.3 0.0 3.1e-13 49.8 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EKE38903.1 - 6.5e-05 22.9 0.1 0.00017 21.6 0.1 1.6 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 EKE38903.1 - 0.00053 19.5 0.2 0.00073 19.1 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EKE38903.1 - 0.01 15.0 0.7 0.014 14.5 0.7 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Peptidase_M20 PF01546.28 EKE38904.1 - 2.7e-14 53.4 0.0 5.5e-14 52.4 0.0 1.4 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EKE38904.1 - 1.4e-07 30.9 0.0 2.4e-05 23.5 0.0 2.5 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase Peptidase_M28 PF04389.17 EKE38904.1 - 0.0099 15.6 0.0 0.64 9.7 0.0 3.0 3 1 1 4 4 4 1 Peptidase family M28 M20_dimer PF07687.14 EKE38904.1 - 0.055 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Peptidase dimerisation domain RasGEF PF00617.19 EKE38905.1 - 5e-42 144.1 3.6 5e-42 144.1 3.6 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EKE38905.1 - 2.6e-09 37.3 2.7 2.6e-09 37.3 2.7 2.6 3 1 0 3 3 3 1 RasGEF N-terminal motif Dynein_light PF01221.18 EKE38905.1 - 0.07 13.5 0.2 0.36 11.2 0.0 2.2 2 0 0 2 2 2 0 Dynein light chain type 1 DUF4230 PF14014.6 EKE38906.1 - 0.007 16.6 1.9 0.011 16.0 0.2 1.8 1 1 0 2 2 2 1 Protein of unknown function (DUF4230) Baculo_E66 PF04850.12 EKE38906.1 - 0.031 13.1 0.0 0.036 12.9 0.0 1.2 1 0 0 1 1 1 0 Baculovirus E66 occlusion-derived virus envelope protein cwf21 PF08312.12 EKE38906.1 - 0.27 11.4 3.6 1.2 9.4 0.6 2.5 2 1 0 2 2 2 0 cwf21 domain NTP_transferase PF00483.23 EKE38907.1 - 0.00022 20.9 0.0 0.0021 17.7 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EKE38907.1 - 0.0028 18.0 0.0 0.0048 17.3 0.0 1.4 1 1 0 1 1 1 1 MobA-like NTP transferase domain Fer4_14 PF13394.6 EKE38907.1 - 0.054 13.6 0.2 0.2 11.8 0.1 2.0 2 1 0 2 2 2 0 4Fe-4S single cluster domain MBOAT_2 PF13813.6 EKE38909.1 - 0.11 12.8 0.0 0.37 11.1 0.0 1.9 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family Trans_coact PF16805.5 EKE38909.1 - 0.14 12.3 1.3 10 6.3 0.0 2.9 3 0 0 3 3 3 0 Phage late-transcription coactivator DUF1286 PF06939.11 EKE38909.1 - 0.32 11.3 5.6 0.56 10.5 0.5 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF1286) Cornichon PF03311.14 EKE38910.1 - 2.2e-08 34.5 0.7 2.3e-08 34.4 0.7 1.0 1 0 0 1 1 1 1 Cornichon protein MGAT2 PF05060.14 EKE38911.1 - 0.049 12.7 1.1 0.086 11.9 0.9 1.5 1 1 0 1 1 1 0 N-acetylglucosaminyltransferase II (MGAT2) Ribosomal_L31e PF01198.19 EKE38912.1 - 2.4e-29 101.4 0.3 5e-29 100.4 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L31e Ras PF00071.22 EKE38913.1 - 3e-52 176.5 0.2 3.4e-52 176.3 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38913.1 - 2.4e-20 73.0 0.0 3.8e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38913.1 - 6.4e-08 32.2 0.1 7.1e-08 32.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE38913.1 - 2.5e-06 27.2 0.3 6.2e-06 25.9 0.2 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE38913.1 - 0.00097 19.2 0.1 0.0017 18.4 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE38913.1 - 0.0049 16.8 1.7 0.16 11.9 0.0 2.2 1 1 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 EKE38913.1 - 0.067 12.3 0.3 4.3 6.4 0.0 2.2 2 1 0 2 2 2 0 G-protein alpha subunit MMR_HSR1_Xtn PF16897.5 EKE38913.1 - 0.093 12.8 0.3 0.16 12.0 0.3 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain DUF3872 PF12988.7 EKE38914.1 - 0.087 12.6 0.1 0.19 11.6 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) CSTF2_hinge PF14327.6 EKE38915.1 - 1.1e-14 54.6 1.5 1.3e-14 54.4 1.5 1.1 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 DASH_Dam1 PF08653.10 EKE38916.1 - 0.81 9.5 12.8 0.91 9.4 0.1 5.1 5 0 0 5 5 5 0 DASH complex subunit Dam1 ApoO PF09769.9 EKE38916.1 - 5.5 7.0 15.6 4.1 7.4 0.4 4.5 2 2 1 4 4 4 0 Apolipoprotein O P_gingi_FimA PF06321.11 EKE38917.1 - 0.021 14.9 0.6 6.8 6.8 0.0 3.6 4 0 0 4 4 4 0 Major fimbrial subunit protein (FimA) UFD1 PF03152.14 EKE38918.1 - 1.8e-61 206.6 0.0 2.3e-61 206.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 EKE38918.1 - 0.01 15.6 0.0 0.023 14.5 0.0 1.5 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 CTP-dep_RFKase PF01982.16 EKE38918.1 - 0.13 12.4 0.0 2.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF120 Metallophos PF00149.28 EKE38919.1 - 3.6e-16 60.3 0.4 6.9e-16 59.4 0.4 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE38919.1 - 3.7e-13 50.0 0.0 2.2e-12 47.5 0.0 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Mre11_DNA_bind PF04152.14 EKE38919.1 - 8.8e-10 39.2 6.2 8.8e-10 39.2 6.2 3.1 2 1 0 2 2 2 1 Mre11 DNA-binding presumed domain DUF3819 PF12842.7 EKE38919.1 - 0.016 15.2 1.2 0.046 13.7 1.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) SAP130_C PF16014.5 EKE38919.1 - 0.87 8.6 6.1 1.4 7.9 6.1 1.3 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus EOS1 PF12326.8 EKE38919.1 - 0.99 9.3 2.5 2.1 8.3 2.5 1.5 1 0 0 1 1 1 0 N-glycosylation protein MRP-S26 PF14943.6 EKE38921.1 - 0.041 13.8 2.4 0.042 13.8 2.4 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Lactamase_B_2 PF12706.7 EKE38922.1 - 4.4e-14 52.5 0.0 5.5e-14 52.2 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EKE38922.1 - 2.6e-09 37.4 1.3 4.1e-09 36.7 1.3 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.6 EKE38922.1 - 0.0014 18.6 0.2 0.0057 16.6 0.2 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain GtrA PF04138.14 EKE38922.1 - 0.0059 16.8 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 GtrA-like protein Lactamase_B_6 PF16661.5 EKE38922.1 - 0.011 15.2 0.1 0.016 14.7 0.1 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain TauE PF01925.19 EKE38923.1 - 3.2e-21 76.1 33.8 1.1e-11 44.8 22.8 2.7 2 1 0 2 2 2 2 Sulfite exporter TauE/SafE SpoIIIAH PF12685.7 EKE38923.1 - 0.027 14.3 2.7 0.11 12.3 3.1 1.8 2 1 0 2 2 2 0 SpoIIIAH-like protein UPF0542 PF15086.6 EKE38923.1 - 0.049 13.6 0.3 5 7.1 0.0 2.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 DUF3169 PF11368.8 EKE38923.1 - 0.075 12.5 0.3 0.075 12.5 0.3 3.8 3 2 0 3 3 3 0 Protein of unknown function (DUF3169) SARAF PF06682.12 EKE38923.1 - 0.19 11.4 0.0 0.45 10.1 0.0 1.6 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Sigma_reg_N PF13800.6 EKE38923.1 - 0.21 11.9 10.1 12 6.2 2.3 3.8 3 0 0 3 3 3 0 Sigma factor regulator N-terminal CHD5 PF04420.14 EKE38923.1 - 0.48 10.3 3.4 0.31 10.9 0.6 2.1 2 0 0 2 2 2 0 CHD5-like protein Ctr PF04145.15 EKE38923.1 - 0.82 10.3 0.0 0.82 10.3 0.0 2.4 2 0 0 2 2 2 0 Ctr copper transporter family PepSY_TM PF03929.16 EKE38923.1 - 1.4 8.5 4.2 18 4.9 4.2 2.7 1 1 0 1 1 1 0 PepSY-associated TM region MIG-14_Wnt-bd PF06664.12 EKE38925.1 - 2.4e-60 204.3 41.7 3.5e-60 203.7 38.3 2.0 2 0 0 2 2 2 2 Wnt-binding factor required for Wnt secretion adh_short PF00106.25 EKE38926.1 - 3.2e-32 111.6 0.5 5e-31 107.7 0.5 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EKE38926.1 - 8.7e-20 71.3 0.0 8.9e-19 68.0 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EKE38926.1 - 4.2e-11 43.1 0.0 6.2e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EKE38926.1 - 6.8e-07 29.0 0.1 1e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EKE38926.1 - 8.3e-05 22.1 0.1 0.00011 21.7 0.1 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EKE38926.1 - 0.0019 17.4 0.4 0.0027 16.9 0.4 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 EKE38926.1 - 0.045 13.1 0.8 0.11 11.8 0.3 1.9 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_4 PF07993.12 EKE38926.1 - 0.047 12.9 0.2 0.16 11.1 0.2 1.8 1 1 0 1 1 1 0 Male sterility protein SBDS_C PF09377.10 EKE38927.1 - 8.1e-22 77.4 6.4 1.3e-21 76.8 6.4 1.3 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 EKE38927.1 - 1.3e-17 63.6 0.9 1.3e-17 63.6 0.9 1.9 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Peptidase_C50 PF03568.17 EKE38927.1 - 0.045 12.9 5.8 0.055 12.6 5.8 1.1 1 0 0 1 1 1 0 Peptidase family C50 SBDS PF01172.18 EKE38928.1 - 2e-07 31.0 0.1 3.7e-07 30.1 0.0 1.4 1 1 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein PARG_cat PF05028.14 EKE38929.1 - 1.2e-65 222.1 1.6 1.8e-65 221.5 1.6 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) DUF1810 PF08837.11 EKE38930.1 - 5.5e-47 159.0 0.0 6.5e-47 158.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1810) Auto_anti-p27 PF06677.12 EKE38931.1 - 3.2e-14 52.8 5.6 5.3e-14 52.1 5.6 1.4 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Cwf_Cwc_15 PF04889.12 EKE38931.1 - 0.091 12.5 7.8 0.12 12.0 7.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PurL_C PF16904.5 EKE38931.1 - 0.19 12.1 1.1 0.6 10.5 0.1 2.3 2 1 1 3 3 3 0 Phosphoribosylformylglycinamidine synthase II C-terminus HECW_N PF16562.5 EKE38932.1 - 0.01 15.6 2.8 0.33 10.8 0.1 2.3 2 0 0 2 2 2 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 DUF1796 PF08795.10 EKE38932.1 - 0.11 12.5 0.5 0.24 11.4 0.5 1.6 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) UBA_e1_thiolCys PF10585.9 EKE38932.1 - 5.5 6.8 16.1 0.97 9.3 1.6 3.1 1 1 2 3 3 3 0 Ubiquitin-activating enzyme active site Arm PF00514.23 EKE38933.1 - 6.5e-07 29.2 0.0 0.0017 18.4 0.0 3.1 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat IBB PF01749.20 EKE38933.1 - 0.062 13.7 1.5 0.14 12.6 1.5 1.6 1 0 0 1 1 1 0 Importin beta binding domain La PF05383.17 EKE38933.1 - 0.069 13.2 2.3 2.7 8.1 0.1 3.8 4 0 0 4 4 4 0 La domain HpuA PF16960.5 EKE38933.1 - 0.1 11.8 0.2 0.17 11.0 0.2 1.2 1 0 0 1 1 1 0 Haemoglobin-haptoglobin utilisation, porphyrin transporter 14-3-3 PF00244.20 EKE38934.1 - 1.3e-100 335.5 9.3 1.5e-100 335.3 9.3 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 EKE38934.1 - 0.0013 19.0 0.3 0.25 11.6 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKE38934.1 - 0.069 13.4 4.3 1.4 9.4 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1653 PF07866.11 EKE38934.1 - 0.18 12.1 2.5 1.7 9.1 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1653) Pkinase PF00069.25 EKE38935.1 - 3.8e-60 203.5 0.3 4.7e-60 203.2 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38935.1 - 3.2e-24 85.6 0.1 4.8e-24 85.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EKE38935.1 - 1.5e-06 28.4 0.0 3.6e-06 27.1 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EKE38935.1 - 0.0047 16.5 0.1 0.0085 15.7 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EKE38935.1 - 0.011 15.3 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EKE38935.1 - 0.028 13.8 0.0 0.048 13.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKE38935.1 - 0.046 12.5 0.0 0.06 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PPO1_DWL PF12142.8 EKE38935.1 - 0.07 12.9 1.4 0.2 11.4 0.2 2.2 2 0 0 2 2 2 0 Polyphenol oxidase middle domain DYW_deaminase PF14432.6 EKE38936.1 - 0.13 12.1 1.6 0.14 12.0 0.4 1.6 2 0 0 2 2 2 0 DYW family of nucleic acid deaminases RabGAP-TBC PF00566.18 EKE38937.1 - 1.7e-27 96.5 5.1 2.4e-27 96.0 5.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Methyltransf_32 PF13679.6 EKE38938.1 - 3.8e-26 92.0 1.3 6.7e-26 91.2 1.3 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKE38938.1 - 0.00057 19.8 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EKE38938.1 - 0.0021 17.7 0.1 0.0044 16.7 0.1 1.5 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_25 PF13649.6 EKE38938.1 - 0.0025 18.5 0.0 0.011 16.5 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain DUF2777 PF10949.8 EKE38938.1 - 0.0062 16.2 0.5 0.065 12.9 0.5 2.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2777) Methyltransf_31 PF13847.6 EKE38938.1 - 0.013 15.3 0.2 0.013 15.3 0.2 2.4 2 2 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EKE38938.1 - 0.014 16.0 0.0 0.038 14.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain IFNGR1 PF07140.11 EKE38938.1 - 0.094 12.8 7.6 0.89 9.7 0.0 3.4 3 1 0 3 3 3 0 Interferon gamma receptor (IFNGR1) Pkinase PF00069.25 EKE38940.1 - 2.7e-42 145.0 0.1 6.1e-42 143.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38940.1 - 2.9e-38 131.6 0.1 7.4e-38 130.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase SH2 PF00017.24 EKE38940.1 - 2.3e-07 30.8 0.1 4.7e-07 29.8 0.1 1.6 1 0 0 1 1 1 1 SH2 domain Kinase-like PF14531.6 EKE38940.1 - 0.13 11.6 0.2 0.41 9.9 0.1 2.0 2 1 0 2 2 2 0 Kinase-like RasGEF PF00617.19 EKE38941.1 - 5.4e-39 134.2 1.0 1.3e-38 132.9 1.0 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE38941.1 - 1.8e-05 24.9 0.5 0.0064 16.7 0.1 3.4 2 1 0 2 2 2 2 RasGEF N-terminal motif Pkinase PF00069.25 EKE38942.1 - 6.9e-51 173.1 0.0 9.4e-51 172.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE38942.1 - 2.4e-44 151.6 0.0 3.2e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE38942.1 - 2.3e-11 43.1 0.1 5.2e-11 42.0 0.0 1.4 1 1 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EKE38942.1 - 1.8e-05 24.3 0.9 3.4e-05 23.5 0.8 1.4 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.14 EKE38942.1 - 0.023 14.1 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-PolyVal PF18762.1 EKE38942.1 - 0.044 13.7 1.5 0.068 13.1 1.5 1.2 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins CheY-binding PF09078.11 EKE38942.1 - 0.077 13.1 0.3 0.68 10.1 0.1 2.2 2 0 0 2 2 2 0 CheY binding DnaJ_C PF01556.18 EKE38944.1 - 8.7e-38 129.7 2.8 1.2e-37 129.3 2.8 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EKE38944.1 - 6.8e-28 96.6 2.2 6.8e-28 96.6 2.2 2.0 2 0 0 2 2 2 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EKE38944.1 - 1.3e-14 54.3 19.9 1.3e-14 54.3 19.9 2.0 2 0 0 2 2 2 1 DnaJ central domain Anti-TRAP PF15777.5 EKE38944.1 - 0.015 15.2 21.1 0.05 13.6 3.6 3.0 3 1 1 4 4 4 0 Tryptophan RNA-binding attenuator protein inhibitory protein LprI PF07007.12 EKE38944.1 - 0.03 15.0 0.1 0.058 14.1 0.1 1.4 1 0 0 1 1 1 0 Lysozyme inhibitor LprI CxC3 PF18804.1 EKE38944.1 - 0.081 12.8 2.2 0.41 10.5 2.2 2.0 1 1 0 1 1 1 0 CxC3 like cysteine cluster associated with KDZ transposases HypA PF01155.19 EKE38944.1 - 1.7 8.7 11.2 2 8.4 1.7 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ank PF00023.30 EKE38945.1 - 3.4e-22 77.8 3.2 0.00017 21.9 0.0 5.5 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EKE38945.1 - 1.5e-20 73.2 6.1 1.6e-06 28.5 0.1 4.6 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKE38945.1 - 2.8e-20 72.7 7.6 3e-07 30.9 0.8 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKE38945.1 - 3.9e-19 66.7 2.6 0.0024 18.2 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EKE38945.1 - 7.9e-14 51.5 3.8 0.00015 22.0 0.1 4.2 4 0 0 4 4 4 3 Ankyrin repeats (many copies) H_lectin PF09458.10 EKE38945.1 - 0.00019 21.5 0.2 0.00052 20.1 0.2 1.8 1 0 0 1 1 1 1 H-type lectin domain Tup_N PF08581.10 EKE38945.1 - 0.051 13.9 1.5 0.45 10.8 0.4 2.6 2 0 0 2 2 2 0 Tup N-terminal Rap_GAP PF02145.15 EKE38946.1 - 3.6e-49 166.9 0.5 4.1e-49 166.7 0.5 1.0 1 0 0 1 1 1 1 Rap/ran-GAP DUF5024 PF16427.5 EKE38947.1 - 0.59 10.5 4.1 0.68 10.3 0.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5024) Cnd1 PF12717.7 EKE38947.1 - 7.2 6.6 17.8 0.25 11.4 2.9 4.5 4 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 TRAM_LAG1_CLN8 PF03798.16 EKE38948.1 - 2.4e-30 105.8 15.7 2.4e-30 105.8 15.7 1.6 2 0 0 2 2 2 1 TLC domain SIR2 PF02146.17 EKE38949.1 - 3.8e-50 170.2 0.0 7.6e-50 169.3 0.0 1.5 2 0 0 2 2 2 1 Sir2 family zf-UBP PF02148.19 EKE38949.1 - 1.9e-18 66.5 15.3 1.9e-18 66.5 15.3 1.9 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 EKE38949.1 - 0.012 15.3 2.0 0.012 15.3 2.0 2.2 2 1 0 2 2 2 0 Variant UBP zinc finger LSM PF01423.22 EKE38950.1 - 7.2e-19 67.2 0.1 8.2e-19 67.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 EKE38950.1 - 0.0088 16.2 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 RimP C-terminal SH3 domain Hfq PF17209.3 EKE38950.1 - 0.0097 15.5 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Hfq protein SlyX PF04102.12 EKE38951.1 - 1.3 9.7 8.2 0.81 10.3 1.2 3.8 4 1 0 4 4 4 0 SlyX LRR_5 PF13306.6 EKE38952.1 - 1.7e-188 616.4 127.1 1.3e-29 102.7 13.4 9.9 5 3 5 10 10 10 10 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE38952.1 - 6.8e-37 125.1 0.0 0.00081 19.1 0.0 13.0 7 3 7 14 14 14 9 Leucine rich repeat LRR_4 PF12799.7 EKE38952.1 - 3.9e-06 27.1 24.6 0.35 11.4 0.0 10.5 9 3 1 10 10 10 3 Leucine Rich repeats (2 copies) YhhN PF07947.14 EKE38953.1 - 3e-25 88.9 18.9 3e-25 88.9 18.9 1.3 2 0 0 2 2 2 1 YhhN family Churchill PF06573.11 EKE38954.1 - 0.11 12.8 1.2 0.25 11.7 1.2 1.6 1 0 0 1 1 1 0 Churchill protein PP2C PF00481.21 EKE38955.1 - 1.4e-44 152.7 0.1 2e-44 152.2 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EKE38955.1 - 1e-24 86.0 60.9 1.7e-10 40.5 11.3 8.1 5 3 2 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EKE38955.1 - 1.1e-19 70.2 80.9 5.7e-05 23.4 8.8 10.6 5 3 6 11 11 11 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EKE38955.1 - 2.6e-07 30.3 35.6 0.0076 15.8 5.8 5.6 1 1 6 7 7 7 4 Leucine-rich repeat LRR_1 PF00560.33 EKE38955.1 - 0.036 14.6 1.8 0.036 14.6 1.8 12.3 11 2 0 11 11 11 0 Leucine Rich Repeat PFK PF00365.20 EKE38956.1 - 7.7e-66 222.3 0.2 9e-66 222.1 0.2 1.0 1 0 0 1 1 1 1 Phosphofructokinase DAGK_cat PF00781.24 EKE38956.1 - 0.03 13.9 0.1 0.082 12.5 0.0 1.8 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain CLU PF13236.6 EKE38956.1 - 0.088 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Clustered mitochondria RasGEF PF00617.19 EKE38957.1 - 2.3e-06 27.9 5.9 2.3e-06 27.9 5.9 2.2 2 0 0 2 2 2 1 RasGEF domain PAP2 PF01569.21 EKE38958.1 - 6.9e-19 68.0 3.8 6.9e-19 68.0 3.8 2.6 3 0 0 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.6 EKE38958.1 - 7.1e-06 25.8 12.1 3.4e-05 23.6 12.1 2.2 1 1 0 1 1 1 1 PAP2 superfamily V-SNARE_C PF12352.8 EKE38959.1 - 2.4e-06 27.7 3.4 3e-06 27.4 3.4 1.2 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus DUF1640 PF07798.11 EKE38959.1 - 0.00096 19.2 0.6 0.0011 19.1 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Pex24p PF06398.11 EKE38959.1 - 0.098 11.6 0.7 0.1 11.6 0.7 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Metallophos PF00149.28 EKE38960.1 - 1.2e-07 32.4 0.2 2.2e-07 31.6 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TEX13 PF15186.6 EKE38961.1 - 0.01 15.5 2.6 0.01 15.5 2.6 3.6 2 1 1 3 3 3 0 Testis-expressed sequence 13 protein family DUF3584 PF12128.8 EKE38961.1 - 0.41 8.1 52.3 2.2 5.7 52.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Lipid_DES PF08557.10 EKE38962.1 - 1.6 8.3 5.6 15 5.2 0.2 2.9 3 0 0 3 3 3 0 Sphingolipid Delta4-desaturase (DES) Syja_N PF02383.18 EKE38965.1 - 2.7e-63 214.2 1.0 2.7e-63 214.2 1.0 2.3 2 0 0 2 2 2 1 SacI homology domain NAC PF01849.18 EKE38966.1 - 0.043 13.8 0.1 0.074 13.0 0.1 1.4 1 0 0 1 1 1 0 NAC domain DSPc PF00782.20 EKE38967.1 - 1e-34 119.2 0.5 1.5e-34 118.6 0.5 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EKE38967.1 - 2.3e-06 27.4 0.0 2.8e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 EKE38967.1 - 0.00016 21.3 0.3 0.00021 20.9 0.3 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Init_tRNA_PT PF04179.12 EKE38967.1 - 0.00041 20.6 0.1 0.0027 18.0 0.1 2.2 2 1 0 2 2 2 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EKE38967.1 - 0.0059 16.7 0.0 0.0083 16.3 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.12 EKE38967.1 - 0.057 13.1 0.0 0.089 12.4 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Bromo_MP PF01573.16 EKE38967.1 - 0.11 11.9 0.1 0.27 10.5 0.1 1.6 1 1 0 2 2 2 0 Bromovirus movement protein Sec5 PF15469.6 EKE38968.1 - 3.7e-36 124.7 5.4 3.7e-36 124.7 5.4 4.9 4 3 1 5 5 5 1 Exocyst complex component Sec5 Vps51 PF08700.11 EKE38968.1 - 9e-05 22.5 0.7 9e-05 22.5 0.7 4.5 4 1 0 4 4 4 1 Vps51/Vps67 SNRNP27 PF08648.12 EKE38968.1 - 0.1 12.7 2.6 2.5 8.2 0.4 3.4 3 0 0 3 3 3 0 U4/U6.U5 small nuclear ribonucleoproteins 23S_rRNA_IVP PF05635.11 EKE38968.1 - 0.53 10.6 0.0 0.53 10.6 0.0 4.2 5 1 0 5 5 5 0 23S rRNA-intervening sequence protein Ras PF00071.22 EKE38969.1 - 7.5e-60 201.2 0.1 8.9e-60 201.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE38969.1 - 2.7e-31 108.3 0.1 4.4e-31 107.6 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE38969.1 - 2.8e-14 53.0 0.1 3.4e-14 52.7 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE38969.1 - 6.7e-06 26.1 0.4 0.033 14.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EKE38969.1 - 4e-05 23.2 0.1 0.098 12.2 0.1 2.1 2 0 0 2 2 2 2 Ferrous iron transport protein B Gtr1_RagA PF04670.12 EKE38969.1 - 6e-05 22.5 0.1 7.1e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE38969.1 - 0.00014 21.9 0.0 0.00024 21.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE38969.1 - 0.00016 21.1 0.0 0.00037 20.0 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EKE38969.1 - 0.00031 21.1 0.0 0.00039 20.9 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 EKE38969.1 - 0.0015 18.3 0.2 0.0037 17.0 0.2 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EKE38969.1 - 0.0019 17.9 0.2 0.0031 17.3 0.2 1.8 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 EKE38969.1 - 0.0032 17.0 0.1 0.012 15.1 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EKE38969.1 - 0.0036 17.6 0.0 0.043 14.1 0.0 2.3 3 0 0 3 3 3 1 AAA domain G-alpha PF00503.20 EKE38969.1 - 0.0051 16.0 2.5 0.14 11.3 0.6 2.6 1 1 1 2 2 2 1 G-protein alpha subunit AAA_5 PF07728.14 EKE38969.1 - 0.022 14.8 0.1 0.056 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DAP3 PF10236.9 EKE38969.1 - 0.022 13.9 0.0 0.044 13.0 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Septin PF00735.18 EKE38969.1 - 0.025 13.9 0.1 0.052 12.8 0.1 1.5 1 0 0 1 1 1 0 Septin KH_10 PF17905.1 EKE38969.1 - 0.032 14.7 0.0 0.068 13.6 0.0 1.5 1 0 0 1 1 1 0 GLD-3 KH domain 5 AAA_7 PF12775.7 EKE38969.1 - 0.06 12.9 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EKE38969.1 - 0.078 13.5 0.9 0.16 12.5 0.9 1.8 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 EKE38969.1 - 0.099 12.0 0.0 0.29 10.5 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein NACHT PF05729.12 EKE38969.1 - 0.13 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Arf PF00025.21 EKE38970.1 - 4.7e-52 175.9 0.1 5.3e-52 175.8 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EKE38970.1 - 1.3e-09 38.3 0.1 1.9e-09 37.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EKE38970.1 - 1.8e-09 37.4 0.1 1.9e-09 37.3 0.1 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EKE38970.1 - 1.1e-07 31.4 0.1 2.1e-07 30.4 0.1 1.5 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EKE38970.1 - 2.8e-07 30.1 0.1 3.1e-07 30.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EKE38970.1 - 2e-05 24.1 0.0 2.6e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit TIR_2 PF13676.6 EKE38970.1 - 0.032 14.9 0.1 0.041 14.5 0.1 1.2 1 0 0 1 1 1 0 TIR domain SoPB_HTH PF18090.1 EKE38970.1 - 0.047 13.8 0.0 0.07 13.3 0.0 1.3 1 0 0 1 1 1 0 Centromere-binding protein HTH domain MMR_HSR1 PF01926.23 EKE38970.1 - 0.065 13.3 0.0 0.12 12.5 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Metallophos PF00149.28 EKE38971.1 - 3.2e-30 106.2 0.2 5.6e-30 105.4 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase NT-C2 PF10358.9 EKE38972.1 - 1.2e-11 44.5 3.1 1.2e-11 44.5 3.1 2.1 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 EKE38972.1 - 0.0011 19.2 0.1 0.0036 17.6 0.1 1.8 1 0 0 1 1 1 1 DIL domain DUF3073 PF11273.8 EKE38972.1 - 0.041 14.6 0.6 0.092 13.5 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3073) DUF2850 PF11012.8 EKE38972.1 - 0.072 13.4 0.0 2.9 8.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2850) HALZ PF02183.18 EKE38972.1 - 0.35 11.1 4.1 0.95 9.7 4.1 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper Aa_trans PF01490.18 EKE38973.1 - 1.1e-19 70.5 34.5 1.1e-19 70.5 34.5 1.5 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 EKE38973.1 - 3.2e-08 32.8 43.3 5.1e-08 32.2 40.6 2.1 2 0 0 2 2 2 1 Amino acid permease Ribosomal_L29e PF01779.17 EKE38975.1 - 1.4e-16 60.5 8.0 2.5e-16 59.7 8.0 1.4 1 0 0 1 1 1 1 Ribosomal L29e protein family Gtr1_RagA PF04670.12 EKE38976.1 - 3.2e-32 111.7 2.5 4.4e-32 111.3 2.5 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE38976.1 - 2.3e-07 30.9 0.1 1.5e-06 28.2 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Arf PF00025.21 EKE38976.1 - 0.00022 20.7 0.3 0.0004 19.9 0.2 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 EKE38976.1 - 0.0063 16.7 0.0 0.015 15.6 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 EKE38976.1 - 0.0079 15.7 0.1 0.021 14.4 0.1 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF3160 PF11369.8 EKE38977.1 - 0.11 10.9 0.2 0.16 10.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3160) DS PF01916.17 EKE38978.1 - 6.6e-104 347.2 0.0 7.6e-104 347.0 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase DUF3933 PF13069.6 EKE38979.1 - 0.03 14.2 0.1 0.044 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3933) PP1 PF07430.11 EKE38979.1 - 0.065 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Phloem filament protein PP1 cystatin-like domain Metallophos PF00149.28 EKE38980.1 - 2.2e-35 123.0 0.0 2.7e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WD40 PF00400.32 EKE38981.1 - 1.7e-20 72.9 13.6 0.0016 19.2 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE38981.1 - 2.1e-12 47.2 0.3 7.2e-06 26.2 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EKE38981.1 - 1.9e-09 37.3 5.5 1.2e-08 34.6 1.1 2.3 1 1 0 2 2 2 2 WD40-like domain PQQ_3 PF13570.6 EKE38981.1 - 0.009 16.5 0.0 21 5.7 0.0 4.6 4 1 1 5 5 5 1 PQQ-like domain Hira PF07569.11 EKE38981.1 - 0.016 14.9 1.0 17 5.0 0.0 3.9 2 1 3 5 5 5 0 TUP1-like enhancer of split Alba PF01918.21 EKE38982.1 - 3.1e-05 23.7 0.3 9.1e-05 22.2 0.1 2.0 2 0 0 2 2 2 1 Alba ERK-JNK_inhib PF15002.6 EKE38982.1 - 0.012 15.3 3.7 0.018 14.7 3.7 1.4 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor DUF1682 PF07946.14 EKE38982.1 - 0.14 11.4 4.1 0.18 11.0 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Aminotran_1_2 PF00155.21 EKE38983.1 - 2.5e-44 152.0 0.0 3.1e-44 151.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EKE38983.1 - 3.6e-06 26.2 0.0 5.7e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EKE38983.1 - 0.0016 17.0 0.0 0.0025 16.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme T-box PF00907.22 EKE38984.1 - 0.26 11.5 4.4 0.73 10.1 0.3 2.4 2 0 0 2 2 2 0 T-box ICMT PF04140.14 EKE38985.1 - 7.6e-27 93.6 0.6 7.6e-27 93.6 0.6 1.7 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EKE38985.1 - 1.6e-08 34.9 1.0 1.6e-08 34.9 1.0 2.4 2 1 1 3 3 3 1 Phospholipid methyltransferase FUN14 PF04930.15 EKE38985.1 - 0.062 13.7 3.7 0.12 12.8 3.7 1.4 1 0 0 1 1 1 0 FUN14 family DUF1295 PF06966.12 EKE38985.1 - 0.8 9.2 6.0 0.43 10.1 4.2 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1295) AI-2E_transport PF01594.16 EKE38986.1 - 1.6e-15 57.1 36.6 2.1e-15 56.7 36.6 1.1 1 0 0 1 1 1 1 AI-2E family transporter GTP_EFTU PF00009.27 EKE38987.1 - 0.076 12.6 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain PI3Ka PF00613.20 EKE38988.1 - 4.8e-51 172.8 0.1 9.5e-51 171.8 0.1 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EKE38988.1 - 1.7e-13 51.0 0.0 3.5e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_rbd PF00794.18 EKE38988.1 - 1.7e-09 37.8 0.0 6.4e-09 35.9 0.0 2.1 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 EKE38988.1 - 1.6e-06 28.1 0.2 3.7e-06 26.9 0.2 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 RhoGEF PF00621.20 EKE38990.1 - 1.9e-17 64.1 9.9 1.9e-17 64.1 9.9 1.8 2 0 0 2 2 2 1 RhoGEF domain IQ PF00612.27 EKE38990.1 - 0.004 16.8 0.2 0.0091 15.7 0.2 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif PAP_fibrillin PF04755.12 EKE38990.1 - 0.012 15.6 2.8 0.24 11.3 0.1 2.4 2 0 0 2 2 2 0 PAP_fibrillin DUF5400 PF17379.2 EKE38990.1 - 0.015 15.8 0.8 0.07 13.6 0.8 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF5400) Herpes_UL92 PF03048.14 EKE38991.1 - 0.0049 16.7 1.0 0.017 14.9 0.5 1.8 2 0 0 2 2 2 1 UL92 family SRP19 PF01922.17 EKE38992.1 - 6.4e-24 84.7 0.5 8.1e-24 84.4 0.5 1.1 1 0 0 1 1 1 1 SRP19 protein Flavi_glycoprot PF00869.20 EKE38992.1 - 0.051 12.8 0.0 0.061 12.5 0.0 1.0 1 0 0 1 1 1 0 Flavivirus glycoprotein, central and dimerisation domains eIF-6 PF01912.18 EKE38993.1 - 2.3e-75 252.3 0.1 2.9e-75 252.0 0.1 1.1 1 0 0 1 1 1 1 eIF-6 family DUF1272 PF06906.11 EKE38994.1 - 0.51 10.5 10.7 0.75 9.9 9.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1272) Prenyltrans PF00432.21 EKE38995.1 - 2.6e-43 145.4 4.5 1.3e-15 56.8 2.8 4.8 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EKE38995.1 - 0.0008 18.6 0.0 0.014 14.5 0.0 2.6 2 1 0 2 2 2 1 Squalene-hopene cyclase N-terminal domain TED_complement PF07678.14 EKE38995.1 - 0.011 14.8 0.0 11 5.0 0.0 3.3 3 1 1 4 4 4 0 A-macroglobulin TED domain Pep3_Vps18 PF05131.14 EKE38996.1 - 0.083 12.7 0.4 0.52 10.1 0.1 2.5 2 0 0 2 2 2 0 Pep3/Vps18/deep orange family zf-RING_11 PF17123.5 EKE38996.1 - 0.12 12.1 6.7 0.022 14.5 1.4 2.5 2 0 0 2 2 2 0 RING-like zinc finger DUF5497 PF17601.2 EKE38996.1 - 0.34 11.3 2.1 3.1 8.2 0.5 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5497) zf-RING_5 PF14634.6 EKE38996.1 - 2.2 8.3 10.2 9.2 6.3 10.2 2.1 1 1 0 1 1 1 0 zinc-RING finger domain UDG PF03167.19 EKE38997.1 - 1.5e-08 34.8 0.0 1.9e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Baculo_LEF-2 PF03041.14 EKE38997.1 - 0.041 13.5 0.3 0.1 12.3 0.2 1.6 1 1 1 2 2 2 0 lef-2 LRR_5 PF13306.6 EKE38998.1 - 3.6e-82 272.7 55.0 4e-30 104.4 11.4 3.9 1 1 4 5 5 5 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE38998.1 - 8.6e-11 41.4 0.0 0.0099 15.6 0.1 4.8 3 2 1 4 4 4 4 Leucine rich repeat Chromadorea_ALT PF05535.12 EKE38998.1 - 0.14 12.4 4.5 0.42 10.8 0.2 3.0 2 1 0 2 2 2 0 Chromadorea ALT protein CLASP_N PF12348.8 EKE38999.1 - 1e-05 25.3 0.6 0.00092 18.8 0.1 2.5 1 1 1 2 2 2 2 CLASP N terminal HEAT PF02985.22 EKE38999.1 - 0.0001 22.2 0.0 0.21 12.0 0.0 3.6 3 0 0 3 3 3 1 HEAT repeat Adaptin_N PF01602.20 EKE38999.1 - 0.00071 18.3 0.3 0.002 16.7 0.1 1.8 2 0 0 2 2 2 1 Adaptin N terminal region Pkinase_Tyr PF07714.17 EKE38999.1 - 0.0022 17.4 0.0 0.01 15.1 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Cnd1 PF12717.7 EKE38999.1 - 0.003 17.6 0.4 2.9 7.9 0.0 3.4 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Pkinase PF00069.25 EKE38999.1 - 0.033 13.6 1.9 0.035 13.5 0.1 1.9 2 0 0 2 2 2 0 Protein kinase domain SOTI PF17079.5 EKE38999.1 - 0.091 13.2 0.1 0.86 10.0 0.0 2.5 2 0 0 2 2 2 0 Male-specific protein scotti Ras PF00071.22 EKE39000.1 - 3e-61 205.8 1.0 3.4e-61 205.6 1.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39000.1 - 4.4e-34 117.3 0.1 7.8e-34 116.5 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39000.1 - 2.4e-16 59.7 0.3 2.9e-16 59.4 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE39000.1 - 8.3e-05 22.6 0.0 0.00015 21.8 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE39000.1 - 0.00016 21.1 0.5 0.0002 20.8 0.5 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE39000.1 - 0.0013 18.3 0.2 0.003 17.1 0.2 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE39000.1 - 0.0015 18.5 1.3 0.67 9.8 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EKE39000.1 - 0.0017 17.8 0.2 0.002 17.6 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 EKE39000.1 - 0.017 14.9 0.2 0.063 13.0 0.0 1.7 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein RhoGAP PF00620.27 EKE39001.1 - 1.5e-34 119.0 0.0 2.7e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain SlyX PF04102.12 EKE39001.1 - 0.038 14.6 0.6 0.038 14.6 0.6 2.4 2 0 0 2 2 2 0 SlyX HTH_39 PF14090.6 EKE39001.1 - 0.11 12.3 0.0 1 9.1 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain Tektin PF03148.14 EKE39001.1 - 0.17 10.6 1.1 0.26 10.0 1.1 1.2 1 0 0 1 1 1 0 Tektin family ATG16 PF08614.11 EKE39001.1 - 1 9.6 3.9 2.3 8.4 3.9 1.6 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) TLD PF07534.16 EKE39002.1 - 1.1e-05 25.7 3.1 0.00058 20.1 0.1 3.1 2 1 1 3 3 3 1 TLD Apolipoprotein PF01442.18 EKE39002.1 - 0.00092 19.1 0.7 0.00092 19.1 0.7 2.6 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain DUF2026 PF09641.10 EKE39002.1 - 0.06 13.0 0.2 0.06 13.0 0.2 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2026) LPP PF04728.13 EKE39002.1 - 0.22 11.9 0.1 0.22 11.9 0.1 5.1 6 1 1 7 7 7 0 Lipoprotein leucine-zipper DUF3846 PF12957.7 EKE39002.1 - 0.26 11.6 2.7 0.41 11.0 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3846) Serine_rich PF08824.10 EKE39002.1 - 0.7 9.9 15.9 0.059 13.4 2.4 3.3 2 1 1 3 3 3 0 Serine rich protein interaction domain YtxH PF12732.7 EKE39002.1 - 1.3 9.7 5.6 5.5e+02 1.2 5.6 3.9 1 1 0 1 1 1 0 YtxH-like protein DUF3533 PF12051.8 EKE39002.1 - 2.3 7.1 19.1 0.1 11.5 11.9 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3533) NPV_P10 PF05531.12 EKE39002.1 - 9.5 6.8 25.1 1.8e+04 -11.4 25.1 4.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Alpha_kinase PF02816.18 EKE39003.1 - 7.2e-46 156.6 0.1 1.1e-45 156.0 0.1 1.3 1 0 0 1 1 1 1 Alpha-kinase family SH3_2 PF07653.17 EKE39003.1 - 4.5e-17 61.5 0.0 4.5e-11 42.2 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 EKE39003.1 - 1.2e-13 50.7 0.0 1.9e-11 43.6 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EKE39003.1 - 2.8e-13 49.2 0.0 1.2e-10 40.8 0.0 2.5 2 0 0 2 2 2 2 SH3 domain Glycoprotein_G PF00802.19 EKE39004.1 - 3.2 7.0 14.7 0.091 12.1 3.9 2.2 1 1 1 2 2 2 0 Pneumovirus attachment glycoprotein G Ank_2 PF12796.7 EKE39005.1 - 3.6e-11 43.5 1.4 4.3e-06 27.2 0.3 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EKE39005.1 - 5.9e-11 42.4 0.3 2.7e-06 27.6 0.2 2.9 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EKE39005.1 - 1.3e-06 28.9 2.8 0.023 15.3 0.1 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EKE39005.1 - 2e-06 28.0 1.5 0.00012 22.3 0.1 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EKE39005.1 - 2e-05 24.6 2.3 0.0066 16.9 0.2 4.3 5 0 0 5 5 5 1 Ankyrin repeat Thioredoxin PF00085.20 EKE39006.1 - 2.6e-11 43.4 0.0 2.7e-11 43.4 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EKE39006.1 - 0.048 14.1 0.0 0.054 13.9 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain PIGA PF08288.12 EKE39007.1 - 2.1e-32 111.6 0.2 8.5e-32 109.6 0.2 2.1 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EKE39007.1 - 1.7e-25 90.0 0.0 2.4e-25 89.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EKE39007.1 - 3.9e-21 75.3 0.0 6.6e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EKE39007.1 - 6.7e-18 65.4 0.0 1.2e-17 64.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EKE39007.1 - 1.2e-11 45.4 0.0 1.5e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EKE39007.1 - 2.9e-05 24.1 0.1 6.1e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like EF-hand_7 PF13499.6 EKE39008.1 - 5.2e-13 49.2 1.2 1.9e-05 25.0 0.4 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EKE39008.1 - 9.4e-12 44.6 6.2 0.00017 21.4 0.4 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EKE39008.1 - 2.1e-11 42.5 4.0 2.7e-06 26.5 0.2 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EKE39008.1 - 3.4e-11 42.1 3.1 7.2e-06 25.5 0.4 3.2 2 1 1 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 EKE39008.1 - 9.9e-07 28.0 0.9 0.00065 19.1 0.3 2.4 2 0 0 2 2 2 2 EF hand CCD48 PF15799.5 EKE39008.1 - 0.12 10.6 0.0 0.14 10.5 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 APG6 PF04111.12 EKE39009.1 - 0.00056 19.9 2.4 0.00064 19.7 0.5 2.2 1 1 1 2 2 2 1 Apg6 BARA domain GPS2_interact PF15784.5 EKE39009.1 - 0.025 15.0 1.6 0.065 13.7 1.6 1.7 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain APG6_N PF17675.1 EKE39009.1 - 0.032 14.8 5.4 0.073 13.6 5.4 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF2959 PF11172.8 EKE39009.1 - 0.068 13.3 3.3 0.12 12.5 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) Cor1 PF04803.12 EKE39009.1 - 0.15 12.3 8.2 0.18 12.0 6.9 1.8 1 1 0 1 1 1 0 Cor1/Xlr/Xmr conserved region YabA PF06156.13 EKE39009.1 - 0.19 12.4 5.3 0.41 11.3 5.3 1.5 1 0 0 1 1 1 0 Initiation control protein YabA TFIID_NTD2 PF04494.15 EKE39009.1 - 0.33 11.2 6.5 0.11 12.8 2.5 2.1 2 0 0 2 2 2 0 WD40 associated region in TFIID subunit, NTD2 domain DUF5342 PF17277.2 EKE39009.1 - 1.1 9.7 4.3 11 6.5 0.4 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5342) START PF01852.19 EKE39010.1 - 3.5e-13 49.4 0.1 4.9e-13 49.0 0.1 1.1 1 0 0 1 1 1 1 START domain Cpn60_TCP1 PF00118.24 EKE39011.1 - 6.5e-71 239.4 14.3 1.1e-70 238.7 14.3 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Glycogen_syn PF05693.13 EKE39012.1 - 0.14 10.7 0.0 0.16 10.5 0.0 1.0 1 0 0 1 1 1 0 Glycogen synthase TLD PF07534.16 EKE39013.1 - 2e-06 28.1 0.5 2e-06 28.1 0.5 1.9 2 0 0 2 2 2 1 TLD MFS_1 PF07690.16 EKE39014.1 - 9.7e-24 83.9 4.7 9.7e-24 83.9 4.7 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Connexin PF00029.19 EKE39014.1 - 0.078 12.7 3.6 0.99 9.1 0.9 2.4 2 0 0 2 2 2 0 Connexin DUF4692 PF15763.5 EKE39014.1 - 0.17 12.4 0.0 0.17 12.4 0.0 2.4 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) TERB2 PF15101.6 EKE39014.1 - 3.3 7.7 7.4 0.14 12.2 0.6 1.9 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Peptidase_S49_N PF08496.10 EKE39014.1 - 6.3 6.9 9.9 20 5.2 0.1 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Roc PF08477.13 EKE39015.1 - 3.2e-05 24.1 0.0 3.4e-05 24.0 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EKE39015.1 - 0.00021 21.0 0.1 0.00021 20.9 0.1 1.0 1 0 0 1 1 1 1 Ras family FeoB_N PF02421.18 EKE39015.1 - 0.094 12.2 0.0 0.097 12.2 0.0 1.0 1 0 0 1 1 1 0 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EKE39015.1 - 0.1 12.7 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EKE39015.1 - 0.11 12.9 0.0 0.12 12.8 0.0 1.1 1 0 0 1 1 1 0 RNA helicase Arf PF00025.21 EKE39015.1 - 0.13 11.7 0.0 0.13 11.7 0.0 1.0 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_16 PF13191.6 EKE39015.1 - 0.18 12.2 0.0 0.18 12.2 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Ras PF00071.22 EKE39016.1 - 1.8e-13 50.4 0.0 2.6e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Isy1 PF06246.12 EKE39016.1 - 0.01 15.5 0.0 0.012 15.2 0.0 1.1 1 0 0 1 1 1 1 Isy1-like splicing family DUF4579 PF15158.6 EKE39016.1 - 0.029 14.1 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4579) RsgA_GTPase PF03193.16 EKE39016.1 - 0.094 12.6 0.0 0.14 12.0 0.0 1.4 1 1 0 1 1 1 0 RsgA GTPase RhoGAP PF00620.27 EKE39017.1 - 1.8e-12 47.3 0.0 2.6e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Mem_trans PF03547.18 EKE39018.1 - 1.8e-38 132.0 0.3 3e-37 127.9 0.3 2.0 1 1 0 1 1 1 1 Membrane transport protein LAP1C PF05609.12 EKE39018.1 - 0.13 11.4 12.0 0.18 10.8 12.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Ricin_B_lectin PF00652.22 EKE39021.1 - 2.2e-06 28.0 0.0 1e-05 25.8 0.0 1.8 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 EKE39021.1 - 1.8e-05 25.4 0.2 0.00028 21.6 0.0 2.5 1 1 2 3 3 3 1 Ricin-type beta-trefoil lectin domain-like SMI1_KNR4 PF09346.10 EKE39022.1 - 0.026 14.9 0.2 0.051 14.0 0.2 1.5 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) TPR_1 PF00515.28 EKE39023.1 - 1.3e-16 59.6 10.1 2.1e-06 27.3 0.6 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat STI1 PF17830.1 EKE39023.1 - 1.7e-15 56.7 0.3 1.2e-10 41.2 0.0 3.0 2 0 0 2 2 2 2 STI1 domain TPR_2 PF07719.17 EKE39023.1 - 4e-15 54.6 10.9 0.00016 21.5 0.1 5.7 6 0 0 6 6 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE39023.1 - 3.9e-10 39.8 2.9 2.2e-06 27.8 0.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EKE39023.1 - 5.8e-08 32.4 13.1 0.22 11.8 0.2 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EKE39023.1 - 7.1e-07 28.8 5.3 4.6e-06 26.2 0.1 3.5 4 1 1 5 5 4 1 TPR repeat TPR_12 PF13424.6 EKE39023.1 - 2.8e-06 27.5 1.2 6.4 7.1 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EKE39023.1 - 3.3e-05 24.4 0.0 0.3 11.8 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EKE39023.1 - 9.4e-05 22.9 1.1 4.8 7.8 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EKE39023.1 - 0.00015 21.5 0.7 6.2 7.1 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EKE39023.1 - 0.00058 20.1 0.1 0.00058 20.1 0.1 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EKE39023.1 - 0.00078 19.5 3.9 0.014 15.5 0.0 3.7 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EKE39023.1 - 0.0019 18.0 2.1 3.1 7.8 0.1 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EKE39023.1 - 0.033 14.2 11.3 0.4 10.7 0.1 4.0 2 2 2 4 4 4 0 Putative TPR-like repeat TPR_14 PF13428.6 EKE39023.1 - 0.047 14.5 0.0 17 6.6 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF384 PF04064.13 EKE39023.1 - 0.13 12.2 0.2 0.13 12.2 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF384) TPR_6 PF13174.6 EKE39023.1 - 0.16 12.7 12.6 24 5.8 0.1 5.9 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 EKE39023.1 - 0.91 9.6 8.1 2.1 8.4 0.1 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat Sterile PF03015.19 EKE39023.1 - 7.7 6.8 7.6 0.81 10.0 1.0 2.8 3 1 1 4 4 4 0 Male sterility protein LapA_dom PF06305.11 EKE39024.1 - 1.6 8.6 0.0 1.6 8.6 0.0 2.8 3 1 1 4 4 4 0 Lipopolysaccharide assembly protein A domain LIM PF00412.22 EKE39025.1 - 7.2e-09 35.7 6.1 1.4e-08 34.8 6.1 1.5 1 0 0 1 1 1 1 LIM domain CENP-Q PF13094.6 EKE39025.1 - 0.00077 19.7 0.3 0.0011 19.2 0.3 1.1 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit zf-met PF12874.7 EKE39025.1 - 0.051 14.0 0.5 0.051 14.0 0.5 3.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type C1_2 PF03107.16 EKE39025.1 - 0.086 13.2 4.8 0.25 11.7 1.5 2.6 2 0 0 2 2 2 0 C1 domain DNA_ligase_ZBD PF03119.16 EKE39025.1 - 0.13 12.3 1.8 0.43 10.6 1.8 2.1 1 1 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Zn_Tnp_IS1595 PF12760.7 EKE39025.1 - 0.15 12.0 4.8 0.2 11.6 3.1 2.0 1 1 1 2 2 2 0 Transposase zinc-ribbon domain SelR PF01641.18 EKE39025.1 - 0.38 10.8 6.6 0.12 12.4 1.7 2.2 1 1 1 2 2 2 0 SelR domain Sgf11 PF08209.11 EKE39025.1 - 0.51 9.9 5.0 1.1 8.8 1.3 2.3 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) LIM PF00412.22 EKE39026.1 - 1.6e-11 44.2 27.7 1.5e-07 31.5 14.2 3.7 3 1 0 3 3 3 2 LIM domain zf-ribbon_3 PF13248.6 EKE39026.1 - 9.9e-05 21.6 1.4 9.9e-05 21.6 1.4 4.1 4 0 0 4 4 4 1 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EKE39026.1 - 0.00021 20.9 4.6 0.00021 20.9 4.6 4.2 4 0 0 4 4 4 1 zinc-ribbon domain DZR PF12773.7 EKE39026.1 - 0.0026 17.8 2.8 0.0026 17.8 2.8 3.9 2 2 0 2 2 2 1 Double zinc ribbon zinc-ribbon_6 PF10005.9 EKE39026.1 - 0.038 14.7 0.7 0.038 14.7 0.7 4.0 3 1 1 4 4 4 0 zinc-ribbon domain DUF4407 PF14362.6 EKE39027.1 - 0.021 14.2 19.6 0.035 13.5 19.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DnaJ_C PF01556.18 EKE39027.1 - 0.026 14.6 0.0 0.026 14.6 0.0 3.1 2 2 1 3 3 3 0 DnaJ C terminal domain DUF812 PF05667.11 EKE39027.1 - 0.15 11.0 39.4 0.22 10.4 39.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Baculo_PEP_C PF04513.12 EKE39027.1 - 0.17 11.9 3.7 0.21 11.6 1.5 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 EKE39027.1 - 0.34 11.4 11.0 2.4 8.7 1.4 4.3 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF489 PF04356.12 EKE39027.1 - 4.2 7.3 7.5 2.2 8.3 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF489) CN_hydrolase PF00795.22 EKE39029.1 - 1.5e-25 90.0 0.0 1.8e-25 89.7 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase zf-4CXXC_R1 PF10497.9 EKE39030.1 - 0.29 11.4 24.7 8.8 6.6 24.7 2.3 1 1 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 YhhN PF07947.14 EKE39031.1 - 1.3e-19 70.6 19.7 1.7e-19 70.2 19.7 1.2 1 0 0 1 1 1 1 YhhN family Cortexin PF11057.8 EKE39031.1 - 0.018 14.9 0.1 0.07 13.0 0.1 2.1 1 1 0 1 1 1 0 Cortexin of kidney Ank_2 PF12796.7 EKE39032.1 - 2.1e-23 82.7 6.9 1.6e-08 35.0 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE39032.1 - 1e-21 77.0 7.3 7.3e-09 36.0 1.3 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE39032.1 - 1.4e-21 74.3 5.9 8.1e-05 22.7 0.1 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EKE39032.1 - 4.4e-21 74.7 9.4 7.2e-11 42.1 0.1 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EKE39032.1 - 4.9e-16 58.4 4.5 0.0029 18.0 0.2 4.8 5 0 0 5 5 5 4 Ankyrin repeat Metallophos PF00149.28 EKE39033.1 - 1.5e-09 38.7 4.4 3.9e-09 37.3 4.4 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE39033.1 - 1.3e-06 28.7 0.1 2.2e-06 28.0 0.1 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain F-box-like PF12937.7 EKE39034.1 - 3.5e-07 30.0 0.2 1.6e-06 27.9 0.2 2.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EKE39034.1 - 0.00078 19.3 0.7 0.0027 17.5 0.7 2.0 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 EKE39034.1 - 0.0078 15.6 4.8 0.069 12.5 4.8 2.4 1 1 0 1 1 1 1 WD40-like domain WD40 PF00400.32 EKE39034.1 - 0.01 16.6 0.1 6.6 7.8 0.0 3.8 3 0 0 3 3 3 0 WD domain, G-beta repeat PQQ_3 PF13570.6 EKE39034.1 - 0.028 14.9 0.5 0.34 11.5 0.0 2.9 3 0 0 3 3 3 0 PQQ-like domain RabGAP-TBC PF00566.18 EKE39035.1 - 1.4e-41 142.5 9.4 2.2e-41 141.9 9.4 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RhoGAP PF00620.27 EKE39036.1 - 3.5e-23 82.1 0.0 1e-22 80.6 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain UBA_4 PF14555.6 EKE39037.1 - 6.5e-11 41.9 0.0 1.2e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.6 EKE39037.1 - 0.00011 22.3 0.0 0.0002 21.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 EKE39037.1 - 0.011 15.9 0.0 0.03 14.5 0.0 1.8 1 0 0 1 1 1 0 UBX domain zf-C3HC4_3 PF13920.6 EKE39038.1 - 4.8e-09 35.9 8.2 7.5e-09 35.3 8.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE39038.1 - 1.2e-08 35.1 11.7 2.3e-08 34.3 11.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EKE39038.1 - 5.4e-07 29.5 11.3 5.4e-07 29.5 11.3 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EKE39038.1 - 1.1e-06 28.4 11.1 1.1e-06 28.4 11.1 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE39038.1 - 1.8e-06 27.7 11.2 3.4e-06 26.8 11.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE39038.1 - 2.6e-06 27.4 7.3 5.9e-06 26.2 7.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EKE39038.1 - 2.8e-06 27.1 10.1 2.8e-06 27.1 10.1 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EKE39038.1 - 5.5e-05 23.2 11.4 9.6e-05 22.5 11.4 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EKE39038.1 - 0.00014 21.6 3.8 0.00027 20.7 3.8 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 EKE39038.1 - 0.0055 16.6 5.3 0.011 15.6 5.3 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.5 EKE39038.1 - 0.082 12.6 7.5 0.16 11.6 7.5 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EKE39038.1 - 0.18 11.7 8.8 0.51 10.2 8.8 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 EKE39038.1 - 0.75 10.1 12.4 0.6 10.4 9.2 2.3 2 1 0 2 2 2 0 RING-H2 zinc finger domain Pkinase PF00069.25 EKE39039.1 - 1.2e-63 214.9 0.1 2.4e-43 148.4 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39039.1 - 7.2e-29 100.9 0.0 1e-28 100.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EKE39039.1 - 3.6e-10 40.0 0.0 1.1e-09 38.5 0.0 1.9 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 EKE39039.1 - 1.3e-06 28.0 0.0 1.9e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EKE39039.1 - 0.0011 19.0 0.0 0.0047 16.9 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EKE39039.1 - 0.011 15.1 0.2 0.02 14.2 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FHA_2 PF17913.1 EKE39039.1 - 0.038 14.2 0.0 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 FHA domain PyrI_C PF02748.15 EKE39040.1 - 0.0014 18.5 1.7 0.0055 16.6 1.7 2.1 1 1 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain Dynactin_p22 PF07426.11 EKE39040.1 - 0.0047 16.8 9.4 0.0047 16.8 9.4 1.9 1 1 1 2 2 2 1 Dynactin subunit p22 HSBP1 PF06825.12 EKE39040.1 - 0.019 14.8 5.6 0.045 13.6 1.2 2.6 2 1 1 3 3 3 0 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.12 EKE39040.1 - 0.02 14.9 4.3 0.028 14.5 4.3 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 EKE39040.1 - 0.064 13.3 10.1 0.18 11.9 10.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 EKE39040.1 - 0.097 12.8 13.2 0.1 12.7 13.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 EKE39040.1 - 0.14 11.3 15.6 0.19 10.8 15.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4200 PF13863.6 EKE39040.1 - 0.27 11.6 18.6 0.33 11.4 18.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF948 PF06103.11 EKE39040.1 - 0.55 10.5 3.7 7.3 6.9 0.6 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 EKE39040.1 - 0.73 10.0 16.0 0.99 9.6 16.0 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Cluap1 PF10234.9 EKE39040.1 - 0.99 8.7 14.3 1.7 8.0 14.3 1.4 1 1 0 1 1 1 0 Clusterin-associated protein-1 Tropomyosin_1 PF12718.7 EKE39040.1 - 2.5 8.2 16.0 0.66 10.1 6.3 2.1 1 1 1 2 2 2 0 Tropomyosin like DUF724 PF05266.14 EKE39040.1 - 5.5 6.8 13.8 4.1 7.2 3.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) NAP PF00956.18 EKE39041.1 - 1.1e-14 54.3 3.7 1.1e-14 54.3 3.7 2.1 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) RIIa PF02197.17 EKE39041.1 - 0.034 13.8 0.1 0.082 12.6 0.1 1.6 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit Peptidase_C1 PF00112.23 EKE39043.1 - 3.3e-72 243.1 4.8 4.9e-72 242.6 4.8 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EKE39043.1 - 6.7e-06 25.1 1.0 0.012 14.4 0.2 2.4 2 1 0 2 2 2 2 Peptidase C1-like family Inhibitor_I29 PF08246.12 EKE39043.1 - 1e-05 25.9 3.2 1.8e-05 25.1 3.2 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_S28 PF05577.12 EKE39045.1 - 2.7e-106 356.0 3.1 3.1e-106 355.8 3.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Hydrolase_4 PF12146.8 EKE39045.1 - 0.00013 21.3 0.0 0.00021 20.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EKE39045.1 - 0.00025 20.6 0.4 0.00045 19.8 0.1 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EKE39045.1 - 0.0018 18.0 0.2 0.077 12.6 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF2920 PF11144.8 EKE39045.1 - 0.0021 17.3 0.1 0.0029 16.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) PfkB PF00294.24 EKE39047.1 - 1e-39 136.7 0.1 1.2e-39 136.4 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EKE39047.1 - 0.036 13.4 0.0 0.056 12.8 0.0 1.2 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase DHHC PF01529.20 EKE39048.1 - 2.2e-26 92.5 13.5 3.6e-26 91.9 13.5 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF4870 PF09685.10 EKE39049.1 - 0.0038 17.3 16.2 0.0049 17.0 16.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4870) DUF1129 PF06570.11 EKE39049.1 - 4.6 6.7 9.4 5.7 6.4 9.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) FA_desaturase PF00487.24 EKE39050.1 - 0.09 12.6 6.0 0.16 11.8 6.0 1.5 1 0 0 1 1 1 0 Fatty acid desaturase CRPA PF05745.11 EKE39050.1 - 1.3 9.1 8.8 1.7 8.7 8.8 1.3 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) DUF2075 PF09848.9 EKE39051.1 - 0.022 14.0 0.4 0.037 13.3 0.3 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PI-PLC-X PF00388.19 EKE39051.1 - 0.034 13.7 0.4 0.042 13.4 0.4 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain DUF2252 PF10009.9 EKE39051.1 - 0.099 11.7 0.3 0.11 11.5 0.3 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) DSPc PF00782.20 EKE39052.1 - 2.4e-06 27.4 0.0 4.4e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EKE39052.1 - 0.00025 21.1 0.0 0.00043 20.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EKE39052.1 - 0.0004 20.0 0.0 0.00066 19.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Corona_S1 PF01600.16 EKE39052.1 - 0.038 12.8 0.5 0.05 12.4 0.5 1.1 1 0 0 1 1 1 0 Coronavirus S1 glycoprotein CDKN3 PF05706.12 EKE39052.1 - 0.057 13.1 0.1 0.12 12.1 0.1 1.6 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 EKE39052.1 - 0.062 12.9 0.1 0.13 11.8 0.1 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF5123 PF17161.4 EKE39052.1 - 0.074 14.1 0.2 0.18 12.9 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5123) PTPlike_phytase PF14566.6 EKE39052.1 - 0.096 12.8 0.1 0.26 11.4 0.0 1.7 2 0 0 2 2 2 0 Inositol hexakisphosphate V-SNARE_C PF12352.8 EKE39053.1 - 1e-07 32.1 5.0 1.3e-07 31.8 1.0 2.4 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus DUF4407 PF14362.6 EKE39053.1 - 0.00017 21.1 4.1 0.00024 20.6 4.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) V-SNARE PF05008.15 EKE39053.1 - 0.006 16.9 9.5 0.029 14.8 2.8 2.8 2 2 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus FlpD PF02662.16 EKE39053.1 - 0.012 15.6 0.6 0.21 11.6 0.1 2.3 1 1 1 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit Uds1 PF15456.6 EKE39053.1 - 0.019 15.1 1.1 0.019 15.1 1.1 2.2 1 1 1 2 2 2 0 Up-regulated During Septation DUF3584 PF12128.8 EKE39053.1 - 0.025 12.1 10.9 0.031 11.8 10.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF2564 PF10819.8 EKE39053.1 - 0.026 14.9 2.1 0.026 14.9 2.1 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2564) FliS PF02561.14 EKE39053.1 - 0.056 13.7 4.4 0.16 12.3 0.7 2.5 2 1 0 2 2 2 0 Flagellar protein FliS KapB PF08810.10 EKE39053.1 - 0.075 13.2 1.3 0.25 11.5 0.7 2.0 1 1 1 2 2 2 0 Kinase associated protein B Fusion_gly PF00523.18 EKE39053.1 - 0.1 10.8 8.4 0.012 13.9 3.3 1.9 2 1 0 2 2 2 0 Fusion glycoprotein F0 T3SS_needle_E PF08988.10 EKE39053.1 - 0.1 12.7 3.5 3 8.1 0.1 3.4 4 1 0 4 4 4 0 Type III secretion system, cytoplasmic E component of needle Snapin_Pallidin PF14712.6 EKE39053.1 - 0.25 11.8 11.8 0.28 11.6 0.9 3.0 2 1 1 3 3 3 0 Snapin/Pallidin DASH_Duo1 PF08651.10 EKE39053.1 - 0.3 10.9 6.0 0.59 10.0 0.3 3.2 3 0 0 3 3 3 0 DASH complex subunit Duo1 DUF1664 PF07889.12 EKE39053.1 - 2.4 8.2 8.4 1.7 8.7 0.9 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EKE39053.1 - 3.1 8.3 13.1 0.99 9.9 4.1 3.1 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein Cas_Cmr5 PF09701.10 EKE39054.1 - 0.2 12.0 1.3 0.32 11.3 0.4 1.7 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cmr5) APG6_N PF17675.1 EKE39054.1 - 0.92 10.0 8.9 0.25 11.9 4.3 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region BCIP PF13862.6 EKE39056.1 - 7.5e-27 94.4 2.2 1.2e-26 93.8 2.2 1.3 1 0 0 1 1 1 1 p21-C-terminal region-binding protein HSP70 PF00012.20 EKE39057.1 - 2.3e-15 55.8 0.4 2.3e-14 52.5 0.3 2.0 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EKE39057.1 - 2.7e-05 23.2 3.5 0.00028 19.8 2.0 2.5 2 1 0 2 2 2 1 MreB/Mbl protein CxxCxxCC PF03692.15 EKE39057.1 - 0.0037 17.9 2.6 0.0039 17.8 0.6 2.1 2 0 0 2 2 2 1 Putative zinc- or iron-chelating domain Fer4_15 PF13459.6 EKE39057.1 - 1.8 9.4 4.9 1.2 9.9 0.2 2.8 3 0 0 3 3 3 0 4Fe-4S single cluster domain DUF1216 PF06746.11 EKE39057.1 - 7.8 6.5 8.8 4.9 7.2 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1216) GCP_N_terminal PF17681.1 EKE39058.1 - 4.8e-32 111.8 1.8 4.8e-32 111.8 1.8 2.1 3 0 0 3 3 3 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EKE39058.1 - 6.7e-25 88.2 3.9 6.7e-25 88.2 3.9 2.0 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal RNA_pol_N PF01194.17 EKE39058.1 - 0.04 14.2 1.4 0.14 12.4 1.4 2.0 1 0 0 1 1 1 0 RNA polymerases N / 8 kDa subunit DUF5638 PF18688.1 EKE39058.1 - 0.46 10.8 6.8 21 5.5 0.0 3.8 3 0 0 3 3 3 0 Family of unknown function (DUF5638) DAD PF02109.16 EKE39059.1 - 1.2e-26 93.1 4.4 1.4e-26 92.9 4.4 1.1 1 0 0 1 1 1 1 DAD family DUF4181 PF13789.6 EKE39059.1 - 0.011 16.0 1.2 0.016 15.5 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) NTP_transf_2 PF01909.23 EKE39060.1 - 0.015 15.6 1.0 0.015 15.6 1.0 3.1 3 1 0 3 3 3 0 Nucleotidyltransferase domain TIG PF01833.24 EKE39061.1 - 8.5e-06 25.8 0.2 8.5e-06 25.8 0.2 2.2 2 1 0 2 2 2 1 IPT/TIG domain DUF3085 PF11284.8 EKE39061.1 - 0.15 12.4 0.2 1.1 9.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3085) FGGY_N PF00370.21 EKE39063.1 - 8.4e-71 238.4 0.5 1.2e-70 237.9 0.5 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EKE39063.1 - 1.8e-46 158.4 0.1 1.4e-45 155.5 0.1 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 EKE39063.1 - 0.0093 15.5 0.6 2.6 7.4 0.0 2.4 2 1 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family RasGEF PF00617.19 EKE39064.1 - 1.4e-28 100.3 0.4 2.5e-28 99.5 0.0 1.6 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EKE39064.1 - 2.7e-09 37.2 1.6 6.8e-09 35.9 0.6 2.2 2 1 0 2 2 2 1 RasGEF N-terminal motif DUF1981 PF09324.10 EKE39064.1 - 0.0054 16.5 1.3 0.012 15.5 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1981) Gag_p10 PF02337.17 EKE39064.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Retroviral GAG p10 protein zf-UBR PF02207.20 EKE39065.1 - 0.021 15.0 4.4 0.039 14.1 4.4 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) RnaseA PF00074.20 EKE39066.1 - 0.055 13.9 0.0 0.22 12.0 0.0 1.8 2 0 0 2 2 2 0 Pancreatic ribonuclease Aminotran_5 PF00266.19 EKE39067.1 - 1.5e-32 113.0 0.0 2.9e-32 112.0 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V Rad51 PF08423.11 EKE39068.1 - 0.0025 17.1 0.0 0.0033 16.7 0.0 1.2 1 0 0 1 1 1 1 Rad51 CobU PF02283.16 EKE39068.1 - 0.012 15.2 0.1 0.027 14.0 0.0 1.6 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase FSAP_sig_propep PF03032.15 EKE39069.1 - 0.049 13.7 0.0 0.049 13.7 0.0 2.1 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide RhoGEF PF00621.20 EKE39070.1 - 3.9e-28 98.9 7.7 3.9e-28 98.9 7.7 2.9 2 1 0 2 2 2 1 RhoGEF domain ArfGap PF01412.18 EKE39070.1 - 2.1e-10 40.7 0.1 2.1e-10 40.7 0.1 3.2 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf CH PF00307.31 EKE39070.1 - 5.4e-09 36.2 0.1 5.4e-09 36.2 0.1 3.0 3 1 0 3 3 3 1 Calponin homology (CH) domain PH PF00169.29 EKE39070.1 - 0.04 14.4 0.0 0.04 14.4 0.0 3.9 3 0 0 3 3 3 0 PH domain RNase_PH PF01138.21 EKE39071.1 - 1.6e-27 96.6 0.1 2.2e-27 96.2 0.1 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EKE39071.1 - 3.7e-05 23.7 0.6 0.00011 22.1 0.2 2.0 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Barwin PF00967.17 EKE39071.1 - 0.24 11.3 0.3 0.43 10.4 0.3 1.3 1 0 0 1 1 1 0 Barwin family Ras PF00071.22 EKE39073.1 - 4.6e-25 88.1 1.8 5.5e-25 87.8 1.8 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39073.1 - 1.1e-15 57.9 0.1 2.4e-15 56.8 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39073.1 - 2.3e-07 30.5 0.1 2.6e-07 30.2 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE39073.1 - 5.9e-06 26.3 0.0 1e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE39073.1 - 0.0005 19.5 0.2 0.0032 16.9 0.0 2.2 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EKE39073.1 - 0.0012 18.4 0.6 0.019 14.5 0.0 2.3 2 1 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 EKE39073.1 - 0.0012 18.6 0.3 0.14 11.8 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 EKE39073.1 - 0.0019 18.6 0.1 0.016 15.6 0.1 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EKE39073.1 - 0.0019 18.2 2.7 0.0055 16.7 0.2 2.1 1 1 1 2 2 2 1 AAA domain ATPase_2 PF01637.18 EKE39073.1 - 0.0047 16.9 0.2 0.0066 16.4 0.1 1.3 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EKE39073.1 - 0.007 16.9 0.3 0.012 16.1 0.3 1.4 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EKE39073.1 - 0.0073 16.2 0.0 0.024 14.5 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EKE39073.1 - 0.0079 16.5 0.0 0.036 14.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain CpxA_peri PF16527.5 EKE39073.1 - 0.012 16.0 0.1 0.024 15.0 0.1 1.5 1 0 0 1 1 1 0 Two-component sensor protein CpxA, periplasmic domain PduV-EutP PF10662.9 EKE39073.1 - 0.015 15.0 0.0 0.05 13.3 0.0 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 EKE39073.1 - 0.053 13.7 0.0 0.078 13.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EKE39073.1 - 0.057 12.8 0.2 0.23 10.9 0.1 1.8 2 0 0 2 2 2 0 Bacterial TniB protein cobW PF02492.19 EKE39073.1 - 0.062 12.9 0.0 0.089 12.4 0.0 1.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain LisH_TPL PF17814.1 EKE39073.1 - 0.14 11.8 1.7 1.8 8.3 0.2 3.0 3 0 0 3 3 3 0 LisH-like dimerisation domain VSP PF03302.13 EKE39075.1 - 5.5e-13 48.5 133.9 9.9e-06 24.7 20.2 5.8 1 1 5 6 6 6 6 Giardia variant-specific surface protein OCD_Mu_crystall PF02423.15 EKE39076.1 - 0.18 10.7 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Mem_trans PF03547.18 EKE39077.1 - 6.7e-28 97.2 11.4 1.2e-27 96.3 11.4 1.4 1 1 0 1 1 1 1 Membrane transport protein DUF2157 PF09925.9 EKE39077.1 - 0.25 11.1 4.3 0.99 9.2 0.3 2.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Pkinase PF00069.25 EKE39078.1 - 7.2e-20 71.5 0.5 1.1e-19 70.8 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39078.1 - 8.7e-14 51.4 0.2 1.2e-13 50.9 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SpoIIIAH PF12685.7 EKE39078.1 - 0.042 13.7 0.1 0.069 13.0 0.1 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Kdo PF06293.14 EKE39078.1 - 0.057 12.8 0.0 0.099 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CD20 PF04103.15 EKE39078.1 - 0.18 11.9 2.8 0.14 12.3 0.5 1.9 2 0 0 2 2 2 0 CD20-like family RasGEF PF00617.19 EKE39079.1 - 2.5e-23 83.2 1.1 7.1e-23 81.7 0.6 2.0 2 0 0 2 2 2 1 RasGEF domain XPG_I PF00867.18 EKE39080.1 - 0.018 15.4 0.0 0.042 14.2 0.0 1.6 1 0 0 1 1 1 0 XPG I-region ERAP1_C PF11838.8 EKE39080.1 - 0.03 13.9 0.0 0.047 13.2 0.0 1.2 1 0 0 1 1 1 0 ERAP1-like C-terminal domain SPOB_a PF14689.6 EKE39080.1 - 0.059 13.1 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Sensor_kinase_SpoOB-type, alpha-helical domain DUF489 PF04356.12 EKE39081.1 - 0.042 13.8 0.5 0.042 13.8 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF489) DUF3201 PF11447.8 EKE39081.1 - 0.5 9.9 5.5 0.14 11.7 2.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3201) Muted PF14942.6 EKE39081.1 - 1.2 9.5 10.4 0.13 12.6 3.2 2.5 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein TLD PF07534.16 EKE39082.1 - 2.7e-10 40.6 6.5 9.1e-08 32.4 1.4 2.3 2 0 0 2 2 2 2 TLD Methyltransf_31 PF13847.6 EKE39084.1 - 3.3e-17 62.7 0.1 4.7e-17 62.2 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE39084.1 - 1.6e-09 38.3 0.0 3.3e-09 37.3 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKE39084.1 - 1.9e-09 37.6 0.0 3.3e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKE39084.1 - 1.1e-08 35.6 0.0 1.9e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EKE39084.1 - 9.4e-08 32.7 0.0 2.1e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EKE39084.1 - 2.8e-06 27.0 0.0 3.7e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 EKE39084.1 - 3.6e-05 23.3 0.1 5.6e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 Tellurite resistance protein TehB PrmA PF06325.13 EKE39084.1 - 4.7e-05 22.9 0.0 6.9e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) AdoMet_MTase PF07757.13 EKE39084.1 - 0.00022 21.5 0.0 0.00039 20.7 0.0 1.5 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 EKE39084.1 - 0.00039 20.4 0.1 0.00059 19.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EKE39084.1 - 0.0004 19.8 0.3 0.00052 19.4 0.3 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MetW PF07021.12 EKE39084.1 - 0.001 18.7 0.1 0.0023 17.6 0.1 1.7 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.7 EKE39084.1 - 0.0014 18.6 0.0 0.0052 16.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EKE39084.1 - 0.0016 17.4 0.0 0.0028 16.6 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.19 EKE39084.1 - 0.0061 16.3 0.0 0.0099 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Pox_MCEL PF03291.16 EKE39084.1 - 0.013 14.6 0.0 0.051 12.7 0.0 1.9 1 1 0 1 1 1 0 mRNA capping enzyme AviRa PF11599.8 EKE39084.1 - 0.034 13.6 0.0 0.064 12.7 0.0 1.4 1 1 0 1 1 1 0 RRNA methyltransferase AviRa DUF4417 PF14386.6 EKE39084.1 - 0.12 12.0 0.1 0.19 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) Myosin_head PF00063.21 EKE39085.1 - 1.2e-245 816.9 5.9 1.2e-245 816.9 5.9 4.4 3 2 0 4 4 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EKE39085.1 - 3.1e-25 88.3 331.6 3.4e-17 61.7 161.2 4.0 1 1 3 4 4 4 4 Myosin tail Spc7 PF08317.11 EKE39085.1 - 1.2e-07 31.0 328.1 0.026 13.4 22.5 12.6 1 1 12 13 13 13 11 Spc7 kinetochore protein Filament PF00038.21 EKE39085.1 - 3.7e-06 26.7 298.8 0.0017 18.0 45.6 9.7 1 1 6 7 7 7 5 Intermediate filament protein SHE3 PF17078.5 EKE39085.1 - 5.5e-05 23.0 16.9 5.5e-05 23.0 16.9 11.6 1 1 9 12 12 12 2 SWI5-dependent HO expression protein 3 EzrA PF06160.12 EKE39085.1 - 0.00051 18.3 27.4 0.00051 18.3 27.4 9.8 2 2 7 9 9 7 3 Septation ring formation regulator, EzrA FPP PF05911.11 EKE39085.1 - 0.00059 18.2 25.9 0.00059 18.2 25.9 9.8 1 1 8 9 9 8 4 Filament-like plant protein, long coiled-coil ADIP PF11559.8 EKE39085.1 - 0.00064 19.8 10.6 0.00064 19.8 10.6 17.6 2 2 16 18 18 17 4 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 EKE39085.1 - 0.001 19.1 27.5 0.001 19.1 27.5 13.8 1 1 11 13 13 12 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PKcGMP_CC PF16808.5 EKE39085.1 - 0.0019 18.0 2.5 0.0019 18.0 2.5 17.1 21 1 1 22 22 16 2 Coiled-coil N-terminus of cGMP-dependent protein kinase Fib_alpha PF08702.10 EKE39085.1 - 0.0033 17.6 9.4 0.0033 17.6 9.4 13.5 4 4 9 13 13 12 5 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EKE39085.1 - 0.0083 16.6 21.2 0.0083 16.6 21.2 12.1 1 1 9 10 10 8 2 Fez1 AAA_22 PF13401.6 EKE39085.1 - 0.093 13.0 5.1 0.14 12.4 0.6 3.9 2 1 0 2 2 2 0 AAA domain APG6_N PF17675.1 EKE39085.1 - 0.37 11.3 369.7 0.68 10.5 17.9 16.8 1 1 12 15 15 15 0 Apg6 coiled-coil region AAA_16 PF13191.6 EKE39085.1 - 0.66 10.3 0.0 0.66 10.3 0.0 5.4 6 1 0 6 6 4 0 AAA ATPase domain ERM PF00769.19 EKE39085.1 - 0.9 9.3 331.4 0.23 11.2 32.0 11.2 1 1 9 11 11 11 0 Ezrin/radixin/moesin family ATG16 PF08614.11 EKE39085.1 - 1.5 9.0 317.6 0.089 13.0 34.7 13.0 1 1 11 12 12 12 0 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 EKE39085.1 - 4.3 6.7 284.7 0.054 13.0 26.4 9.5 1 1 8 9 9 9 0 Golgin subfamily A member 5 KASH_CCD PF14662.6 EKE39085.1 - 8.4 6.2 325.9 0.0076 16.1 39.4 11.5 1 1 8 11 11 11 0 Coiled-coil region of CCDC155 or KASH UCH PF00443.29 EKE39086.1 - 3.9e-41 141.2 14.3 3.9e-41 141.2 14.3 3.9 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE39086.1 - 5.8e-11 42.6 19.2 5.8e-11 42.6 19.2 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Dpoe2NT PF12213.8 EKE39086.1 - 3.7 7.9 14.2 0.89 9.9 0.3 4.8 4 1 1 5 5 5 0 DNA polymerases epsilon N terminal Fib_alpha PF08702.10 EKE39087.1 - 0.00027 21.1 12.6 0.00027 21.1 12.6 3.3 3 1 1 4 4 4 1 Fibrinogen alpha/beta chain family SAM_KSR1 PF13543.6 EKE39087.1 - 0.0014 18.8 2.4 0.0014 18.8 2.4 2.7 2 1 0 2 2 2 1 SAM like domain present in kinase suppressor RAS 1 CutA1 PF03091.15 EKE39087.1 - 0.05 13.5 1.1 0.17 11.8 0.9 2.0 1 1 0 1 1 1 0 CutA1 divalent ion tolerance protein NAPRTase_C PF17956.1 EKE39087.1 - 0.08 13.4 1.1 1 9.8 0.2 2.6 1 1 1 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain Cation_efflux PF01545.21 EKE39088.1 - 2.1e-45 154.9 1.5 3.4e-45 154.2 1.5 1.3 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EKE39088.1 - 0.0048 17.0 0.1 0.017 15.3 0.1 1.9 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Phage_holin_8 PF16931.5 EKE39088.1 - 0.14 12.2 1.1 0.9 9.5 0.1 2.3 1 1 1 2 2 2 0 Putative phage holin Proton_antipo_N PF00662.20 EKE39088.1 - 1.2 9.2 6.5 0.27 11.3 2.0 2.4 2 0 0 2 2 2 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus DSPc PF00782.20 EKE39089.1 - 3.8e-28 98.0 0.5 5.1e-28 97.5 0.1 1.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EKE39089.1 - 0.0033 17.0 0.0 0.0046 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EKE39089.1 - 0.039 14.1 0.1 0.063 13.4 0.1 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate RIC1 PF07064.13 EKE39091.1 - 5.8e-08 32.5 1.8 6.5e-08 32.3 0.1 2.0 2 0 0 2 2 2 1 RIC1 Corona_NS1 PF06145.11 EKE39091.1 - 0.0016 17.9 1.9 0.0045 16.5 1.9 1.8 1 0 0 1 1 1 1 Coronavirus nonstructural protein NS1 PGM_PMM_I PF02878.16 EKE39092.1 - 3.6e-34 117.4 0.2 6.6e-34 116.6 0.2 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EKE39092.1 - 8e-23 80.8 0.0 1.7e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EKE39092.1 - 1.6e-10 41.5 0.0 3.8e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EKE39092.1 - 7e-08 32.5 0.0 1.8e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain CRIM PF16978.5 EKE39094.1 - 5.6e-13 49.2 1.8 4.5e-06 26.9 0.1 3.3 3 0 0 3 3 3 3 SAPK-interacting protein 1 (Sin1), middle CRIM domain AAA_9 PF12781.7 EKE39094.1 - 5.3 6.1 9.7 28 3.8 7.6 2.4 2 0 0 2 2 2 0 ATP-binding dynein motor region DHHC PF01529.20 EKE39095.1 - 1.2e-35 122.5 4.1 1.2e-35 122.5 4.1 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Phage_Cox PF10743.9 EKE39096.1 - 0.08 13.0 0.1 0.14 12.3 0.1 1.5 1 1 0 1 1 1 0 Regulatory phage protein cox DUF2540 PF10802.8 EKE39096.1 - 0.98 9.5 6.2 6.2 7.0 0.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2540) FRG1 PF06229.12 EKE39100.1 - 0.39 10.4 5.2 0.67 9.6 5.2 1.4 1 0 0 1 1 1 0 FRG1-like domain CRA PF06589.11 EKE39100.1 - 9.9 6.3 13.8 28 4.8 13.8 1.8 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) TRAM_LAG1_CLN8 PF03798.16 EKE39101.1 - 1.2e-27 97.0 22.7 1.2e-27 97.0 22.7 1.5 2 0 0 2 2 2 1 TLC domain HSP20 PF00011.21 EKE39102.1 - 5.4e-14 52.2 0.0 7.7e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EKE39102.1 - 0.0001 21.8 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Sec7 PF01369.20 EKE39103.1 - 4.8e-13 49.2 2.4 4.8e-13 49.2 2.4 3.9 4 1 0 4 4 4 1 Sec7 domain DUF5427 PF10310.9 EKE39103.1 - 0.057 12.4 0.9 0.098 11.6 0.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Histone PF00125.24 EKE39105.1 - 3.1e-35 121.4 2.0 3.6e-35 121.2 2.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EKE39105.1 - 3.6e-05 23.8 0.1 6.9e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EKE39105.1 - 7.5e-05 23.0 0.0 0.00014 22.2 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EKE39105.1 - 0.016 15.5 0.1 0.028 14.7 0.1 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Inositol_P PF00459.25 EKE39106.1 - 8.3e-56 189.5 0.1 1.1e-55 189.1 0.1 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family MutS_V PF00488.21 EKE39107.1 - 2.9e-71 239.4 1.0 6.7e-71 238.2 1.0 1.6 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 EKE39107.1 - 5.7e-31 107.1 0.0 1.4e-30 105.8 0.0 1.8 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 EKE39107.1 - 2.4e-29 102.9 0.2 1.1e-28 100.8 0.1 2.1 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EKE39107.1 - 5.6e-06 26.7 0.0 1.6e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 MutS domain II LisH_TPL PF17814.1 EKE39107.1 - 0.051 13.2 0.8 1.4 8.6 0.1 2.6 2 0 0 2 2 2 0 LisH-like dimerisation domain AAA_28 PF13521.6 EKE39107.1 - 0.059 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EKE39107.1 - 0.15 11.9 3.2 0.47 10.3 0.9 2.7 2 1 0 2 2 2 0 NTPase AAA_23 PF13476.6 EKE39107.1 - 1.7 9.1 8.7 0.48 10.9 0.2 2.8 3 0 0 3 3 3 0 AAA domain MutS_IV PF05190.18 EKE39107.1 - 5.8 7.3 7.3 0.42 11.0 1.2 2.4 3 0 0 3 3 3 0 MutS family domain IV DUF3755 PF12579.8 EKE39108.1 - 0.2 11.4 2.6 0.2 11.3 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3755) DEAD PF00270.29 EKE39109.1 - 1.2e-34 119.6 0.1 3.4e-34 118.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE39109.1 - 4.9e-31 107.3 1.5 2.6e-29 101.8 0.2 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EKE39109.1 - 0.00016 21.7 0.1 0.00016 21.7 0.1 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit LRR_5 PF13306.6 EKE39110.1 - 1.4e-72 241.6 64.9 3.6e-29 101.3 16.4 4.8 3 1 2 5 5 5 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE39110.1 - 1.1e-16 60.4 1.9 0.00096 18.9 0.0 5.8 2 2 3 5 5 5 4 Leucine rich repeat VP40 PF07447.12 EKE39110.1 - 0.096 11.8 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Matrix protein VP40 HECT PF00632.25 EKE39111.1 - 8.2e-79 265.3 1.4 8.2e-79 265.3 1.4 3.1 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) PsbH PF00737.20 EKE39112.1 - 0.3 10.9 1.9 0.64 9.8 1.9 1.4 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein ArfGap PF01412.18 EKE39113.1 - 3.3e-33 114.2 0.2 1.1e-32 112.6 0.2 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ank_5 PF13857.6 EKE39113.1 - 2.5e-12 46.8 0.2 5.8e-12 45.6 0.2 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EKE39113.1 - 5.5e-11 42.4 1.1 3.7e-06 27.1 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EKE39113.1 - 2.1e-08 34.6 0.2 6.2e-08 33.1 0.2 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE39113.1 - 1.4e-06 28.7 0.1 9.3e-05 22.9 0.0 2.8 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE39113.1 - 1.8e-06 27.8 0.5 0.0017 18.6 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeat SF3A3 PF16837.5 EKE39113.1 - 0.055 14.0 0.1 0.19 12.2 0.1 1.9 1 0 0 1 1 1 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Metallophos PF00149.28 EKE39115.1 - 2.4e-25 90.2 0.0 4.8e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RRM_1 PF00076.22 EKE39116.1 - 2.4e-61 203.5 1.1 2.5e-22 78.5 0.2 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKE39116.1 - 1.3e-12 47.4 0.3 0.0053 16.3 0.0 3.1 1 1 2 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKE39116.1 - 2.2e-11 43.4 0.0 2.4e-09 36.9 0.0 2.6 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EKE39116.1 - 4e-09 36.5 1.1 0.00063 19.8 0.1 4.2 3 2 0 3 3 3 2 RNA recognition motif SET_assoc PF11767.8 EKE39116.1 - 8.7e-06 25.3 0.2 0.14 11.8 0.0 3.2 3 0 0 3 3 3 2 Histone lysine methyltransferase SET associated RRM_3 PF08777.11 EKE39116.1 - 9.2e-05 22.4 2.2 0.049 13.7 0.0 2.6 2 1 1 3 3 3 2 RNA binding motif Nup35_RRM PF05172.13 EKE39116.1 - 0.00022 21.2 4.7 0.031 14.2 1.7 3.0 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 EKE39116.1 - 0.00049 20.1 0.6 3.2 7.9 0.0 3.4 3 2 0 3 3 3 2 Limkain b1 PHM7_cyt PF14703.6 EKE39116.1 - 0.0016 18.7 0.4 12 6.1 0.0 3.7 2 2 1 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter RL PF17797.1 EKE39116.1 - 0.0023 17.8 0.4 0.041 13.8 0.0 2.4 2 0 0 2 2 2 1 RL domain DUF3078 PF11276.8 EKE39116.1 - 0.025 15.0 0.3 0.094 13.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3078) Nup35_RRM_2 PF14605.6 EKE39116.1 - 0.03 14.3 0.5 3.4 7.8 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif DUF1440 PF07274.12 EKE39116.1 - 0.035 14.5 0.0 0.066 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1440) BRAP2 PF07576.12 EKE39116.1 - 0.052 13.8 0.1 0.89 9.8 0.0 2.6 3 0 0 3 3 3 0 BRCA1-associated protein 2 DbpA PF03880.15 EKE39116.1 - 0.1 12.6 0.1 0.48 10.5 0.0 2.1 2 0 0 2 2 2 0 DbpA RNA binding domain TLD PF07534.16 EKE39117.1 - 1.2e-05 25.5 2.0 1.6e-05 25.2 2.0 1.3 1 1 0 1 1 1 1 TLD zf-Dof PF02701.15 EKE39118.1 - 0.01 15.9 5.8 0.01 15.9 5.8 2.5 3 0 0 3 3 3 0 Dof domain, zinc finger YozE_SAM_like PF06855.12 EKE39118.1 - 0.041 14.0 0.0 0.075 13.2 0.0 1.4 1 0 0 1 1 1 0 YozE SAM-like fold Lar_restr_allev PF14354.6 EKE39118.1 - 0.048 14.1 2.6 0.048 14.1 2.6 2.4 2 1 0 2 2 2 0 Restriction alleviation protein Lar zinc_ribbon_2 PF13240.6 EKE39118.1 - 0.34 10.7 0.2 0.34 10.7 0.2 4.7 6 0 0 6 6 6 0 zinc-ribbon domain DZR PF12773.7 EKE39118.1 - 0.48 10.5 15.9 0.21 11.6 3.3 3.2 2 2 0 2 2 2 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 EKE39118.1 - 0.77 9.9 15.8 1.1 9.4 0.1 4.3 4 0 0 4 4 4 0 Zinc ribbon domain zf_UBZ PF18439.1 EKE39118.1 - 0.8 9.3 7.8 5.9 6.6 0.2 3.4 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger TFIIS_C PF01096.18 EKE39118.1 - 1.3 8.9 11.9 2.4 8.1 0.3 4.2 4 0 0 4 4 4 0 Transcription factor S-II (TFIIS) NOB1_Zn_bind PF08772.11 EKE39118.1 - 1.3 9.2 8.2 6.7 6.9 0.2 2.9 2 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-ISL3 PF14690.6 EKE39118.1 - 1.4 9.7 0.1 1.4 9.7 0.1 3.3 3 1 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-FPG_IleRS PF06827.14 EKE39118.1 - 3.1 7.8 9.7 13 5.7 0.2 3.6 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS RNA_POL_M_15KD PF02150.16 EKE39118.1 - 9.4 6.2 17.5 0.3 11.0 2.4 3.7 2 1 0 2 2 2 0 RNA polymerases M/15 Kd subunit Pkinase PF00069.25 EKE39120.1 - 7.8e-67 225.4 0.0 9e-67 225.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39120.1 - 2.7e-37 128.4 0.0 3.6e-37 128.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE39120.1 - 1.1e-09 38.1 0.0 2.7e-09 36.8 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKE39120.1 - 2.3e-05 23.9 0.0 3.3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EKE39120.1 - 0.00013 22.0 0.0 0.035 14.0 0.0 2.1 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EKE39120.1 - 0.0068 15.4 0.1 0.011 14.7 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EKE39120.1 - 0.093 11.8 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 EKE39120.1 - 0.29 9.8 0.3 0.59 8.8 0.2 1.4 1 1 0 1 1 1 0 Fungal protein kinase DUF2116 PF09889.9 EKE39122.1 - 1.7 8.7 5.8 4.8 7.2 0.3 2.8 2 1 1 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF5102 PF17104.5 EKE39123.1 - 0.00044 20.4 0.0 0.0007 19.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) DCP2 PF05026.13 EKE39124.1 - 2.3e-17 63.1 4.6 2.3e-17 63.1 4.6 1.8 2 0 0 2 2 2 1 Dcp2, box A domain NUDIX PF00293.28 EKE39124.1 - 1.2e-08 35.0 0.0 2.1e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain WD40 PF00400.32 EKE39125.1 - 0.71 10.8 2.7 18 6.4 0.3 4.1 4 1 0 4 4 4 0 WD domain, G-beta repeat RPAP1_C PF08620.10 EKE39126.1 - 9.3e-15 54.5 0.0 2e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 RPAP1-like, C-terminal SPACA9 PF15120.6 EKE39127.1 - 0.0015 18.4 8.6 0.0054 16.5 8.5 2.1 1 1 0 1 1 1 1 Sperm acrosome-associated protein 9 Mce4_CUP1 PF11887.8 EKE39127.1 - 0.034 13.6 0.1 0.27 10.6 0.0 1.9 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Jnk-SapK_ap_N PF09744.9 EKE39127.1 - 0.23 11.7 46.5 1.9 8.7 21.2 2.9 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 FlaC_arch PF05377.11 EKE39127.1 - 8.9 6.8 28.8 1.6 9.2 4.3 4.2 3 2 0 3 3 3 0 Flagella accessory protein C (FlaC) AvrB_AvrC PF05394.11 EKE39127.1 - 9.2 5.4 11.2 1.6 7.9 5.9 1.9 1 1 0 2 2 2 0 Avirulence protein DUF3584 PF12128.8 EKE39127.1 - 9.6 3.6 35.8 1.2 6.5 16.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Pkinase PF00069.25 EKE39128.1 - 2.5e-51 174.6 0.1 3.7e-51 174.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39128.1 - 1.8e-49 168.3 0.0 2.4e-49 168.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE39128.1 - 5.6e-07 28.7 0.1 1.1e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase DUF4083 PF13314.6 EKE39128.1 - 0.2 11.6 4.1 0.51 10.3 4.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Ras PF00071.22 EKE39129.1 - 7.2e-48 162.3 0.1 1.1e-47 161.6 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39129.1 - 1.5e-17 63.9 0.1 6e-17 62.0 0.0 1.9 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39129.1 - 6e-09 35.6 0.1 8e-09 35.2 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE39129.1 - 0.00031 20.7 0.6 0.0051 16.7 0.1 2.4 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EKE39129.1 - 0.00049 19.7 0.1 0.001 18.6 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PPTA PF01239.22 EKE39130.1 - 4.1e-41 137.6 10.0 4.5e-10 38.9 0.5 5.6 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat Nas2_N PF18265.1 EKE39131.1 - 6.7e-21 74.0 0.6 1e-20 73.4 0.6 1.3 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_2 PF13180.6 EKE39131.1 - 2.3e-08 34.2 0.0 3.8e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 EKE39131.1 - 6.7e-07 29.1 0.0 1.3e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EKE39131.1 - 9.5e-05 22.7 0.1 0.00016 22.0 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Seryl_tRNA_N PF02403.22 EKE39131.1 - 0.023 14.9 0.4 0.038 14.2 0.4 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DNA_repr_REX1B PF14966.6 EKE39131.1 - 0.049 14.3 0.5 7.2 7.3 0.1 2.3 2 0 0 2 2 2 0 DNA repair REX1-B YvrJ PF12841.7 EKE39131.1 - 0.19 11.3 2.0 0.19 11.3 0.1 2.0 3 0 0 3 3 3 0 YvrJ protein family Pkinase PF00069.25 EKE39132.1 - 4.8e-60 203.1 0.0 5.7e-60 202.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39132.1 - 5.4e-25 88.1 0.0 1.3e-24 86.9 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE39132.1 - 1.9e-05 24.1 0.0 4.2e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EKE39132.1 - 0.0014 18.3 0.1 0.0023 17.6 0.1 1.4 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 EKE39132.1 - 0.0088 15.7 1.3 0.016 14.8 1.3 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKE39132.1 - 0.013 15.4 0.1 0.02 14.8 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EKE39132.1 - 0.022 14.1 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ACT_3 PF10000.9 EKE39132.1 - 0.15 12.0 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 ACT domain Yos1 PF08571.10 EKE39135.1 - 1.4e-19 70.1 0.3 1.6e-19 70.0 0.3 1.0 1 0 0 1 1 1 1 Yos1-like 14-3-3 PF00244.20 EKE39136.1 - 0.0044 16.5 1.2 0.0073 15.8 1.2 1.2 1 0 0 1 1 1 1 14-3-3 protein Fip1 PF05182.13 EKE39136.1 - 0.13 11.8 0.4 0.31 10.6 0.4 1.6 1 0 0 1 1 1 0 Fip1 motif HAD_2 PF13419.6 EKE39137.1 - 3.2e-25 89.2 0.5 3.9e-25 89.0 0.5 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKE39137.1 - 4.3e-10 40.2 1.1 2.2e-08 34.7 1.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EKE39137.1 - 9.5e-05 22.5 0.0 0.018 15.2 0.0 2.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EKE39137.1 - 0.00042 20.8 0.0 0.00077 19.9 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 EKE39137.1 - 0.0037 17.1 0.2 0.18 11.6 0.2 2.3 1 1 0 1 1 1 1 Acid Phosphatase Hydrolase_3 PF08282.12 EKE39137.1 - 0.006 16.3 0.1 0.2 11.3 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase 5_nucleotid_C PF02872.18 EKE39137.1 - 0.17 12.1 0.6 7.3 6.8 0.2 2.3 1 1 1 2 2 2 0 5'-nucleotidase, C-terminal domain Aldo_ket_red PF00248.21 EKE39138.1 - 4.6e-53 180.3 0.2 1.5e-52 178.6 0.2 1.7 1 1 0 1 1 1 1 Aldo/keto reductase family Metallophos PF00149.28 EKE39139.1 - 1.5e-33 117.1 0.4 2.1e-33 116.5 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ribosomal_L9_C PF03948.14 EKE39139.1 - 0.0049 17.3 1.1 0.0091 16.4 1.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L9, C-terminal domain EF-hand_1 PF00036.32 EKE39141.1 - 2.4e-27 92.4 7.4 4.1e-06 26.0 0.0 4.1 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 EKE39141.1 - 2.9e-24 83.4 8.6 3.8e-06 26.1 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EKE39141.1 - 1e-23 83.5 2.8 6.8e-12 45.7 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EKE39141.1 - 1.4e-23 80.7 7.4 4.3e-05 23.1 0.4 4.2 3 1 1 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EKE39141.1 - 4.7e-20 71.2 5.9 0.00044 20.0 0.2 4.1 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EKE39141.1 - 1.4e-08 35.1 0.1 0.00077 19.8 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EKE39141.1 - 1.7e-06 27.8 2.4 0.73 9.7 0.0 3.9 4 0 0 4 4 4 3 EF hand Dockerin_1 PF00404.18 EKE39141.1 - 3.2e-05 24.0 1.9 2.4 8.4 0.0 4.0 3 1 0 3 3 3 2 Dockerin type I domain EF-hand_4 PF12763.7 EKE39141.1 - 0.00075 19.4 2.7 0.67 9.9 0.2 3.2 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand DUF5109 PF17134.4 EKE39141.1 - 0.025 14.5 0.7 1.9 8.4 0.0 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF5109) Cro PF09048.10 EKE39141.1 - 0.025 14.6 0.3 4.2 7.5 0.0 2.9 3 0 0 3 3 3 0 Cro RelB_N PF18506.1 EKE39141.1 - 0.034 13.9 1.5 1.1 9.1 0.0 2.7 3 0 0 3 3 3 0 RelB Antitoxin alpha helical domain DUF1707 PF08044.11 EKE39141.1 - 0.13 12.3 0.1 21 5.3 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1707) DUF1456 PF07308.13 EKE39141.1 - 0.18 12.2 1.0 2.4 8.6 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1456) A_deaminase PF00962.22 EKE39142.1 - 3.1e-133 444.1 0.4 5.1e-71 239.7 0.1 2.4 2 0 0 2 2 2 2 Adenosine/AMP deaminase zf-B_box PF00643.24 EKE39142.1 - 0.0046 17.1 9.4 0.011 15.8 9.4 1.7 1 0 0 1 1 1 1 B-box zinc finger TCP PF03634.13 EKE39143.1 - 0.0081 16.7 0.6 0.018 15.6 0.6 1.7 1 1 0 1 1 1 1 TCP family transcription factor DENN PF02141.21 EKE39144.1 - 1.9e-14 54.1 3.9 3.8e-13 49.8 3.8 2.4 1 1 0 1 1 1 1 DENN (AEX-3) domain Methyltransf_4 PF02390.17 EKE39146.1 - 7.3e-21 74.4 0.0 6.6e-20 71.3 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase PPR PF01535.20 EKE39146.1 - 0.0016 18.5 0.1 16 6.0 0.1 4.6 4 0 0 4 4 4 1 PPR repeat FBA PF04300.13 EKE39146.1 - 0.0042 16.8 0.6 0.021 14.5 0.5 2.0 2 0 0 2 2 2 1 F-box associated region PPR_2 PF13041.6 EKE39146.1 - 0.007 16.5 0.2 0.59 10.4 0.0 3.6 1 1 3 4 4 4 2 PPR repeat family PPR_3 PF13812.6 EKE39146.1 - 0.05 13.7 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Pentatricopeptide repeat domain RPM2 PF08579.11 EKE39146.1 - 0.058 13.8 1.2 0.33 11.4 0.0 2.7 2 1 1 3 3 3 0 Mitochondrial ribonuclease P subunit (RPM2) AKAP7_NLS PF10469.9 EKE39147.1 - 8.1e-21 74.9 0.5 8.8e-21 74.7 0.5 1.0 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 EKE39147.1 - 0.00017 21.5 0.0 0.0002 21.3 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LuxT_C PF18285.1 EKE39147.1 - 0.015 15.8 0.1 0.045 14.3 0.1 1.7 2 0 0 2 2 2 0 Tetracycline repressor LuxT C-terminal domain Hydant_A_N PF05378.13 EKE39147.1 - 0.016 14.9 0.1 0.019 14.7 0.1 1.1 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region DUF4473 PF14747.6 EKE39147.1 - 0.019 15.5 0.2 0.041 14.4 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) Phage_RpbA PF10789.9 EKE39147.1 - 0.023 14.8 0.3 0.029 14.4 0.3 1.2 1 0 0 1 1 1 0 Phage RNA polymerase binding, RpbA DUF4888 PF16229.5 EKE39147.1 - 0.03 14.3 0.3 0.035 14.1 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4888) tRNA-Thr_ED PF08915.11 EKE39147.1 - 0.034 14.2 0.1 0.041 14.0 0.1 1.2 1 0 0 1 1 1 0 Archaea-specific editing domain of threonyl-tRNA synthetase Peptidase_M16_C PF05193.21 EKE39147.1 - 0.038 14.0 0.0 0.054 13.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase M16 inactive domain SPG48 PF14764.6 EKE39147.1 - 0.044 14.2 0.0 0.054 14.0 0.0 1.1 1 0 0 1 1 1 0 AP-5 complex subunit, vesicle trafficking DUF4358 PF14270.6 EKE39147.1 - 0.053 13.8 1.6 0.11 12.8 0.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4358) Csm1_B PF18211.1 EKE39147.1 - 0.092 12.6 0.6 0.19 11.5 0.6 1.6 1 0 0 1 1 1 0 Csm1 subunit domain B Ca_bind_SSO6904 PF18249.1 EKE39147.1 - 0.19 12.1 4.1 0.28 11.6 4.1 1.3 1 1 0 1 1 1 0 Calcium binding protein SSO6904 Dynein_light PF01221.18 EKE39149.1 - 1e-26 93.1 1.7 1.1e-26 92.9 1.7 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 DUF4752 PF15944.5 EKE39149.1 - 0.045 13.8 0.1 0.076 13.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) TLD PF07534.16 EKE39151.1 - 0.0023 18.2 1.9 0.0037 17.5 1.9 1.4 1 0 0 1 1 1 1 TLD Aminotran_1_2 PF00155.21 EKE39152.1 - 1.2e-10 41.1 0.0 1.4e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EKE39152.1 - 0.051 12.9 0.0 0.07 12.4 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase Pkinase_Tyr PF07714.17 EKE39153.1 - 3.3e-34 118.3 0.0 5.8e-34 117.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE39153.1 - 1.5e-27 96.6 0.1 2.7e-27 95.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EKE39153.1 - 7.3e-25 87.0 5.2 5.9e-07 29.9 0.0 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE39153.1 - 1.4e-22 79.4 4.7 9.3e-09 35.4 0.0 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKE39153.1 - 1.5e-21 76.7 4.8 3.3e-12 46.8 0.1 3.8 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 EKE39153.1 - 1.8e-21 75.6 4.4 0.00047 20.5 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 EKE39153.1 - 1.9e-19 67.7 9.5 0.00035 20.8 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat RtcB PF01139.17 EKE39154.1 - 5.3e-149 496.9 1.1 6.4e-149 496.6 1.1 1.1 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB UDPG_MGDP_dh_C PF03720.15 EKE39154.1 - 0.02 15.3 0.2 0.051 14.0 0.2 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Not1 PF04054.15 EKE39155.1 - 1.2e-44 152.8 19.9 2.1e-23 82.9 5.7 3.2 3 0 0 3 3 3 2 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EKE39155.1 - 2.6e-19 69.5 2.6 9.2e-19 67.7 2.6 2.0 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 EKE39155.1 - 7.7e-13 48.0 0.9 2.8e-12 46.2 0.0 2.4 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF1981 PF09324.10 EKE39155.1 - 0.037 13.9 0.9 5.6 6.9 0.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) DNTTIP1_dimer PF18192.1 EKE39155.1 - 0.26 11.7 3.4 6.2 7.2 0.1 3.4 3 0 0 3 3 3 0 DNTTIP1 dimerisation domain Nuc_sug_transp PF04142.15 EKE39156.1 - 6.6e-77 258.7 25.2 7.6e-77 258.6 25.2 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EKE39156.1 - 4.9e-11 43.0 33.6 1.6e-07 31.5 13.6 2.4 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EKE39156.1 - 0.00067 18.7 9.8 0.00067 18.7 9.8 2.4 2 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 EKE39156.1 - 0.0015 17.8 26.6 0.11 11.6 26.6 3.0 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.16 EKE39156.1 - 0.064 12.6 22.7 0.61 9.4 22.4 2.4 1 1 0 1 1 1 0 Triose-phosphate Transporter family PUNUT PF16913.5 EKE39156.1 - 0.23 10.7 26.3 0.52 9.5 26.3 1.6 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport DUF1129 PF06570.11 EKE39156.1 - 0.4 10.2 0.0 0.4 10.2 0.0 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF1129) DUF3742 PF12553.8 EKE39156.1 - 0.45 10.6 1.4 1 9.5 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) DUF1765 PF08578.10 EKE39157.1 - 5e-20 72.2 11.5 5e-20 72.2 11.5 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) IFP_35_N PF07334.13 EKE39157.1 - 0.0075 16.3 0.4 0.026 14.6 0.4 1.9 1 0 0 1 1 1 1 Interferon-induced 35 kDa protein (IFP 35) N-terminus YlbE PF14003.6 EKE39157.1 - 0.07 13.6 0.5 0.24 11.9 0.5 2.0 1 0 0 1 1 1 0 YlbE-like protein RNA_pol_A_bac PF01000.26 EKE39159.1 - 4e-26 91.6 0.1 5.3e-25 88.0 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EKE39159.1 - 2e-10 40.0 0.0 2.2e-10 39.8 0.0 1.3 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain TLD PF07534.16 EKE39160.1 - 0.00078 19.7 0.0 0.0012 19.1 0.0 1.3 1 0 0 1 1 1 1 TLD YkyA PF10368.9 EKE39160.1 - 0.018 14.7 0.5 0.022 14.4 0.5 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein RNA_pol_Rpb1_3 PF04983.18 EKE39160.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 3 RhoGAP PF00620.27 EKE39160.1 - 0.12 12.2 0.1 0.18 11.6 0.1 1.3 1 0 0 1 1 1 0 RhoGAP domain FliD_N PF02465.18 EKE39160.1 - 0.34 11.6 2.0 0.72 10.6 2.0 1.7 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus BtpA PF03437.15 EKE39161.1 - 2.9e-65 220.2 0.5 3.3e-65 220.0 0.5 1.0 1 0 0 1 1 1 1 BtpA family His_biosynth PF00977.21 EKE39161.1 - 0.0074 15.8 0.1 0.018 14.5 0.1 1.6 2 0 0 2 2 2 1 Histidine biosynthesis protein Trp_syntA PF00290.20 EKE39161.1 - 0.01 14.7 0.1 0.016 14.1 0.1 1.3 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PRAI PF00697.22 EKE39161.1 - 0.03 14.1 0.0 0.055 13.2 0.0 1.4 1 1 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase WD40 PF00400.32 EKE39162.1 - 4.2e-18 65.4 1.8 0.00038 21.2 0.2 7.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE39162.1 - 3.2e-06 27.3 0.2 3.8 7.9 0.0 6.9 5 3 4 9 9 9 1 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EKE39162.1 - 8.8e-06 26.0 1.5 1.7e-05 25.1 1.5 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family SBDS PF01172.18 EKE39163.1 - 8e-14 51.5 0.1 1.8e-13 50.4 0.1 1.6 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 EKE39163.1 - 5.3e-13 49.0 0.1 8.3e-13 48.4 0.1 1.3 1 0 0 1 1 1 1 SBDS protein C-terminal domain TPK_catalytic PF04263.16 EKE39163.1 - 0.038 14.0 0.3 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 Thiamin pyrophosphokinase, catalytic domain Dynein_attach_N PF15867.5 EKE39163.1 - 0.046 13.7 1.2 0.1 12.5 0.6 1.9 2 0 0 2 2 2 0 Dynein attachment factor N-terminus Sec20 PF03908.13 EKE39164.1 - 0.00018 21.3 1.2 0.00024 21.0 1.2 1.2 1 0 0 1 1 1 1 Sec20 Laminin_II PF06009.12 EKE39164.1 - 0.039 14.0 0.4 0.049 13.7 0.4 1.1 1 0 0 1 1 1 0 Laminin Domain II PIEZO PF15917.5 EKE39164.1 - 6.5 6.2 8.2 0.058 12.9 0.5 1.5 2 0 0 2 2 2 0 Piezo SPRY PF00622.28 EKE39165.1 - 7.9e-13 48.6 1.2 1.4e-12 47.8 1.2 1.5 1 0 0 1 1 1 1 SPRY domain Pentapeptide_4 PF13599.6 EKE39166.1 - 0.046 13.9 0.6 0.046 13.9 0.6 3.2 4 0 0 4 4 4 0 Pentapeptide repeats (9 copies) Metallophos PF00149.28 EKE39167.1 - 1.5e-07 32.2 1.7 1.5e-07 32.2 1.7 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pkinase PF00069.25 EKE39168.1 - 1.3e-49 169.0 0.7 2.1e-49 168.2 0.7 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39168.1 - 1.3e-47 162.3 0.1 2.2e-47 161.5 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE39168.1 - 6.8e-06 25.1 0.0 1.5e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Orf78 PF06024.12 EKE39168.1 - 1.5 9.2 4.5 4.9 7.5 4.5 1.9 1 0 0 1 1 1 0 Orf78 (ac78) AMP-binding PF00501.28 EKE39169.1 - 7.8e-68 229.0 0.0 1.2e-67 228.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EKE39169.1 - 2.9e-42 144.6 0.3 1.5e-41 142.3 0.3 1.9 1 1 0 1 1 1 1 Male sterility protein AMP-binding_C PF13193.6 EKE39169.1 - 8.6e-19 68.3 0.0 2.4e-18 66.9 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.19 EKE39169.1 - 8e-09 34.9 2.4 1.5e-08 34.0 2.4 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EKE39169.1 - 3.2e-06 26.8 0.1 6e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EKE39169.1 - 3.1e-05 24.0 0.1 6.5e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 KR domain PP-binding PF00550.25 EKE39169.1 - 0.00036 20.8 0.0 0.00078 19.7 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 EKE39169.1 - 0.00071 18.8 1.8 0.0012 18.0 1.8 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein HSP70 PF00012.20 EKE39170.1 - 5.2e-30 104.2 0.6 5.2e-30 104.2 0.6 2.1 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EKE39170.1 - 0.00024 20.0 0.6 0.00024 20.0 0.6 2.6 3 1 0 3 3 3 1 MreB/Mbl protein FtsA PF14450.6 EKE39170.1 - 0.037 14.5 2.5 0.18 12.2 0.1 2.8 3 0 0 3 3 3 0 Cell division protein FtsA Alpha_Helical PF18489.1 EKE39170.1 - 0.14 12.4 6.7 0.31 11.2 0.4 2.5 2 0 0 2 2 2 0 Alpha helical domain FGGY_C PF02782.16 EKE39170.1 - 0.23 11.1 0.2 1.1 9.0 0.1 2.0 2 1 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain RasGEF PF00617.19 EKE39172.1 - 1.7e-22 80.5 5.0 1.7e-22 80.5 5.0 2.2 3 1 1 4 4 4 1 RasGEF domain PUF PF00806.19 EKE39174.1 - 1.3e-32 109.6 12.0 2.6e-07 30.0 0.2 5.3 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat YbaJ PF10757.9 EKE39174.1 - 0.026 15.1 0.1 0.1 13.2 0.0 2.0 1 1 1 2 2 2 0 Biofilm formation regulator YbaJ CPL PF08144.11 EKE39174.1 - 0.048 14.0 1.2 24 5.3 0.0 3.8 1 1 3 4 4 4 0 CPL (NUC119) domain Cas_Cas4 PF01930.17 EKE39175.1 - 0.06 13.5 0.4 5 7.2 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function DUF83 DUF1126 PF06565.12 EKE39175.1 - 0.077 12.8 0.2 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 DUF1126 PH-like domain DUF2905 PF11146.8 EKE39176.1 - 0.16 12.1 0.0 3.7 7.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2905) Fer4_7 PF12838.7 EKE39177.1 - 5.7e-15 55.7 25.3 1.2e-09 38.6 15.7 1.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 EKE39177.1 - 2.4e-14 52.4 21.6 8.6e-10 38.0 5.3 2.1 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 EKE39177.1 - 2.7e-12 46.6 24.3 2.1e-08 34.2 15.1 1.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EKE39177.1 - 1.8e-11 44.0 27.8 6.3e-08 32.6 17.2 1.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EKE39177.1 - 8e-11 41.5 18.7 1.2e-08 34.6 2.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 EKE39177.1 - 7.4e-08 33.2 13.8 6.2e-05 23.9 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 EKE39177.1 - 9.9e-08 32.0 17.6 1.1e-05 25.4 18.4 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EKE39177.1 - 6.2e-07 29.1 17.1 2.8e-06 27.1 2.7 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EKE39177.1 - 7.3e-07 29.2 19.2 6.8e-06 26.2 3.0 2.1 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 EKE39177.1 - 1.3e-05 25.6 11.3 0.0019 18.6 1.8 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_17 PF13534.6 EKE39177.1 - 2.1e-05 25.0 7.5 0.0061 17.1 0.9 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_3 PF12798.7 EKE39177.1 - 0.00044 21.0 22.7 0.00047 20.9 5.1 2.2 2 0 0 2 2 2 1 4Fe-4S binding domain ETF_QO PF05187.13 EKE39177.1 - 0.0022 18.1 8.8 0.045 13.9 4.3 2.0 1 1 1 2 2 2 2 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_18 PF13746.6 EKE39177.1 - 0.0036 17.5 16.4 0.028 14.6 10.4 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_22 PF17179.4 EKE39177.1 - 0.0042 17.9 1.0 0.0042 17.9 1.0 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_15 PF13459.6 EKE39177.1 - 0.01 16.6 16.1 0.16 12.7 16.1 2.3 1 1 0 1 1 1 0 4Fe-4S single cluster domain Fer4_13 PF13370.6 EKE39177.1 - 0.18 12.3 21.6 45 4.7 21.6 2.7 1 1 0 1 1 1 0 4Fe-4S single cluster domain of Ferredoxin I LSM PF01423.22 EKE39178.1 - 3e-18 65.3 0.2 3.6e-18 65.0 0.2 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EKE39178.1 - 0.00016 21.8 0.0 0.00018 21.5 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EKE39178.1 - 0.067 13.3 0.0 0.079 13.1 0.0 1.3 1 0 0 1 1 1 0 Scd6-like Sm domain SH3_1 PF00018.28 EKE39179.1 - 4.8e-17 61.3 0.1 5.3e-06 25.9 0.0 4.6 4 0 0 4 4 4 4 SH3 domain SH3_2 PF07653.17 EKE39179.1 - 1.1e-15 57.1 0.3 0.00026 20.6 0.0 5.1 5 0 0 5 5 5 4 Variant SH3 domain SH3_9 PF14604.6 EKE39179.1 - 5.6e-14 51.7 0.1 1.1e-05 25.2 0.0 4.6 4 0 0 4 4 4 2 Variant SH3 domain SH3_3 PF08239.11 EKE39179.1 - 0.0016 18.7 0.2 1.2 9.5 0.0 2.6 2 0 0 2 2 2 2 Bacterial SH3 domain Neprosin PF03080.15 EKE39179.1 - 0.0023 17.3 0.1 0.091 12.1 0.1 2.2 2 0 0 2 2 2 1 Neprosin PC4 PF02229.16 EKE39180.1 - 9.5e-19 66.8 0.3 1.9e-18 65.8 0.3 1.5 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) PA26 PF04636.13 EKE39180.1 - 0.55 9.1 10.1 0.63 8.9 10.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) RP-C_C PF11800.8 EKE39180.1 - 0.55 10.3 5.1 0.53 10.3 5.1 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Neur_chan_memb PF02932.16 EKE39180.1 - 0.79 9.7 6.3 0.78 9.8 6.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3438 PF11920.8 EKE39180.1 - 1.2 8.3 8.4 1.7 7.8 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) Vfa1 PF08432.10 EKE39180.1 - 1.3 9.3 25.2 1.5 9.1 25.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4778 PF16008.5 EKE39180.1 - 1.5 8.8 8.8 1.6 8.7 8.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) DDHD PF02862.17 EKE39180.1 - 1.7 8.7 6.1 2 8.5 6.1 1.2 1 0 0 1 1 1 0 DDHD domain MCM_bind PF09739.9 EKE39180.1 - 3.2 6.1 12.3 3.3 6.1 12.3 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SLC12 PF03522.15 EKE39180.1 - 3.8 6.4 14.8 4.3 6.2 14.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 NPR3 PF03666.13 EKE39180.1 - 5.1 5.8 16.2 5.2 5.7 16.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NARP1 PF12569.8 EKE39180.1 - 6.2 5.6 25.6 8 5.2 25.6 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Dsh_C PF12316.8 EKE39180.1 - 6.2 7.2 8.3 7.3 6.9 8.3 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Sec62 PF03839.16 EKE39180.1 - 9.2 5.7 20.9 12 5.4 20.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Arrestin_C PF02752.22 EKE39182.1 - 1.4e-07 32.0 0.3 1.5e-06 28.7 0.3 2.6 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EKE39182.1 - 3e-05 24.1 0.1 9.4e-05 22.5 0.1 1.8 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EKE39182.1 - 0.0096 15.6 0.0 0.022 14.4 0.0 1.6 1 0 0 1 1 1 1 Arrestin_N terminal like Rgp1 PF08737.10 EKE39182.1 - 0.073 12.2 1.0 2.7 7.1 0.1 2.6 3 0 0 3 3 3 0 Rgp1 C2 PF00168.30 EKE39182.1 - 0.17 12.2 0.1 0.61 10.4 0.0 2.1 2 0 0 2 2 2 0 C2 domain AMP-binding PF00501.28 EKE39183.1 - 4.6e-71 239.6 0.0 5.6e-71 239.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EKE39183.1 - 0.00024 22.0 0.0 0.0005 21.0 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ribosomal_L44 PF00935.19 EKE39184.1 - 5.2e-34 116.6 17.5 6.9e-34 116.2 17.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 NOB1_Zn_bind PF08772.11 EKE39184.1 - 0.00077 19.6 0.8 0.00077 19.6 0.8 2.2 1 1 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like Ribosomal_L24e PF01246.20 EKE39185.1 - 1.1e-06 28.8 0.4 1.1e-06 28.8 0.4 2.5 2 1 0 2 2 2 1 Ribosomal protein L24e DUF4407 PF14362.6 EKE39185.1 - 2.7 7.3 9.6 3.2 7.0 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Seryl_tRNA_N PF02403.22 EKE39185.1 - 4.3 7.6 20.9 16 5.8 20.8 1.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TRAP-gamma PF07074.12 EKE39186.1 - 0.053 13.1 0.6 0.093 12.3 0.6 1.5 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) CSF-1 PF05337.11 EKE39186.1 - 0.063 13.4 1.4 0.13 12.4 1.4 1.6 1 1 0 1 1 1 0 Macrophage colony stimulating factor-1 (CSF-1) Cyclin_N PF00134.23 EKE39187.1 - 4.9e-25 87.7 0.6 4.9e-25 87.7 0.6 2.4 3 1 1 4 4 4 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EKE39187.1 - 8.2e-23 80.7 0.7 2.5e-22 79.2 0.7 1.8 1 0 0 1 1 1 1 Cyclin, C-terminal domain EF-hand_3 PF09069.11 EKE39188.1 - 0.049 14.1 0.3 0.95 9.9 0.0 2.4 2 0 0 2 2 2 0 EF-hand zf-CCHC PF00098.23 EKE39189.1 - 2e-19 68.7 22.5 8.5e-07 28.8 2.3 3.5 3 0 0 3 3 3 3 Zinc knuckle RRM_1 PF00076.22 EKE39189.1 - 1.4e-09 37.6 0.1 3e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-ribbon_3 PF13248.6 EKE39189.1 - 6.9e-05 22.1 8.5 0.13 11.7 0.6 3.6 3 0 0 3 3 3 3 zinc-ribbon domain zf-CCHC_4 PF14392.6 EKE39189.1 - 0.0015 18.2 11.2 0.39 10.5 0.3 3.4 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 EKE39189.1 - 0.08 12.9 15.7 0.39 10.7 1.2 3.6 2 1 1 3 3 3 0 Zinc knuckle DZR PF12773.7 EKE39189.1 - 0.42 10.7 11.9 1.4 9.0 2.1 2.2 1 1 1 2 2 2 0 Double zinc ribbon IBR PF01485.21 EKE39189.1 - 1.1 9.6 13.4 14 6.0 0.3 3.9 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain zinc_ribbon_2 PF13240.6 EKE39189.1 - 4.9 7.0 14.4 1.7 8.5 1.9 3.6 3 0 0 3 3 3 0 zinc-ribbon domain Dapper PF15268.6 EKE39189.1 - 8.2 5.1 37.8 12 4.6 37.8 1.3 1 0 0 1 1 1 0 Dapper Alpha-amylase PF00128.24 EKE39190.1 - 1.3e-45 156.4 0.7 2.2e-31 109.7 0.1 3.1 2 1 1 3 3 3 3 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 EKE39190.1 - 0.12 11.5 0.1 0.18 10.9 0.1 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Peptidase_C54 PF03416.19 EKE39191.1 - 2e-24 86.5 0.0 4.3e-22 78.8 0.0 2.1 1 1 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 EKE39191.1 - 1.2e-05 24.8 0.0 0.00018 21.1 0.0 2.2 2 0 0 2 2 2 1 Peptidase family C78 Flavin_Reduct PF01613.18 EKE39192.1 - 2.4e-12 47.1 0.0 3.2e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain TMEM144 PF07857.12 EKE39193.1 - 1.1e-90 304.0 13.1 1.8e-46 158.6 4.3 2.0 1 1 1 2 2 2 2 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 EKE39193.1 - 4.5e-13 49.2 14.8 1.1e-07 31.5 5.6 2.5 2 1 0 2 2 2 2 Sugar transport protein Ureide_permease PF07168.11 EKE39193.1 - 0.00012 21.0 9.2 0.12 11.1 1.8 3.6 2 2 1 3 3 3 2 Ureide permease TP53IP5 PF15331.6 EKE39193.1 - 0.11 12.6 4.4 0.16 12.1 4.4 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 TbpB_A PF17484.2 EKE39193.1 - 0.94 10.2 5.8 1.7 9.4 5.8 1.5 1 1 0 1 1 1 0 N-Lobe handle Tf-binding protein B RRP36 PF06102.12 EKE39193.1 - 1.7 8.6 11.6 2.5 8.1 11.6 1.1 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 DMT_YdcZ PF04657.13 EKE39193.1 - 2.7 8.3 16.8 0.035 14.4 6.9 2.5 2 1 0 2 2 2 0 Putative inner membrane exporter, YdcZ AlaDh_PNT_N PF05222.15 EKE39194.1 - 7.9e-07 29.4 0.0 1.5e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EKE39194.1 - 0.18 12.3 2.2 0.37 11.3 2.2 1.5 1 0 0 1 1 1 0 4TM region of pyridine nucleotide transhydrogenase, mitoch Flavodoxin_5 PF12724.7 EKE39195.1 - 2.5e-06 27.8 0.1 0.0017 18.6 0.0 2.2 1 1 1 2 2 2 2 Flavodoxin domain DUF3688 PF12461.8 EKE39195.1 - 0.0062 15.0 3.3 0.43 8.9 0.7 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3688) Flavodoxin_4 PF12682.7 EKE39195.1 - 0.026 14.2 0.6 0.062 13.0 0.5 1.6 1 1 0 1 1 1 0 Flavodoxin Flavodoxin_2 PF02525.17 EKE39195.1 - 0.026 14.2 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin-like fold FMN_red PF03358.15 EKE39195.1 - 0.033 13.9 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.25 EKE39195.1 - 0.045 13.9 0.1 8.8 6.5 0.0 2.8 2 1 1 3 3 3 0 Flavodoxin Actin PF00022.19 EKE39196.1 - 2.9e-10 39.3 0.1 1.3e-05 24.0 0.1 2.6 1 1 1 2 2 2 2 Actin DHHC PF01529.20 EKE39197.1 - 1.8e-35 121.9 23.7 4.9e-35 120.5 15.5 2.2 2 0 0 2 2 2 2 DHHC palmitoyltransferase Ig_4 PF16680.5 EKE39197.1 - 0.098 12.9 1.0 0.21 11.9 1.0 1.5 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain zf-UBR PF02207.20 EKE39197.1 - 0.23 11.7 7.3 0.46 10.7 7.3 1.4 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Imm17 PF15562.6 EKE39197.1 - 0.23 11.4 0.1 0.23 11.4 0.1 3.5 4 0 0 4 4 4 0 Immunity protein 17 Acetyltransf_1 PF00583.25 EKE39198.1 - 9.7e-11 41.9 0.0 1.1e-10 41.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EKE39198.1 - 1.8e-05 25.0 0.0 3e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EKE39198.1 - 8.6e-05 22.5 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain UTP15_C PF09384.10 EKE39199.1 - 1.1e-33 116.0 1.1 1.7e-33 115.3 1.1 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EKE39199.1 - 2.1e-19 69.5 9.9 0.00072 20.3 0.1 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE39199.1 - 8.4e-11 42.0 0.0 9.6e-05 22.6 0.0 4.1 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EKE39199.1 - 0.00025 21.0 1.4 0.0018 18.2 0.1 2.5 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A DUF4870 PF09685.10 EKE39200.1 - 0.18 11.9 7.6 0.24 11.5 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) Phage_holin_3_6 PF07332.11 EKE39200.1 - 0.62 10.1 6.1 1.1 9.3 6.1 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2070 PF09843.9 EKE39200.1 - 2.4 6.4 9.2 2.7 6.2 9.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF1764 PF08576.10 EKE39202.1 - 5.2e-17 62.6 20.6 3.8e-16 59.8 20.6 2.4 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) Nop14 PF04147.12 EKE39202.1 - 0.2 9.8 11.1 0.23 9.6 11.1 1.0 1 0 0 1 1 1 0 Nop14-like family XRN_M PF17846.1 EKE39202.1 - 0.96 8.3 5.9 1 8.3 5.9 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Sec62 PF03839.16 EKE39202.1 - 4.4 6.7 12.0 5.3 6.5 12.0 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4337 PF14235.6 EKE39202.1 - 6.9 6.8 9.5 8.1 6.5 9.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Ras PF00071.22 EKE39203.1 - 2e-29 102.2 0.2 2.4e-29 102.0 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39203.1 - 6e-08 32.9 0.0 1.6e-07 31.6 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EKE39203.1 - 0.004 17.1 0.4 0.4 10.6 0.1 2.2 1 1 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 EKE39203.1 - 0.012 14.9 0.1 0.016 14.5 0.1 1.3 1 1 0 1 1 1 0 AIG1 family Arf PF00025.21 EKE39203.1 - 0.055 12.9 0.1 0.085 12.3 0.1 1.4 1 1 0 1 1 1 0 ADP-ribosylation factor family ParA PF10609.9 EKE39203.1 - 0.079 12.4 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase AAA_24 PF13479.6 EKE39203.1 - 0.097 12.4 0.1 0.21 11.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EKE39203.1 - 0.1 12.3 0.0 0.28 10.9 0.0 1.6 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.14 EKE39203.1 - 0.18 11.8 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EKE39203.1 - 0.19 12.1 0.0 0.32 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain SprA-related PF12118.8 EKE39204.1 - 0.0062 15.7 9.3 0.008 15.4 9.3 1.1 1 0 0 1 1 1 1 SprA-related family RuvX PF03652.15 EKE39204.1 - 0.086 13.2 5.6 0.13 12.7 5.6 1.4 1 0 0 1 1 1 0 Holliday junction resolvase AAA_23 PF13476.6 EKE39204.1 - 0.25 11.8 16.9 0.38 11.2 16.9 1.3 1 0 0 1 1 1 0 AAA domain DUF3316 PF11777.8 EKE39204.1 - 0.33 11.0 4.3 0.89 9.6 4.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3316) zf-RING_9 PF13901.6 EKE39204.1 - 3 7.8 5.9 3.2 7.7 5.1 1.5 1 1 1 2 2 2 0 Putative zinc-RING and/or ribbon Vfa1 PF08432.10 EKE39204.1 - 7.4 6.9 20.4 9.9 6.4 20.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Glyco_transf_56 PF07429.11 EKE39205.1 - 0.15 11.2 0.0 0.26 10.4 0.0 1.4 1 1 0 1 1 1 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 Rap_GAP PF02145.15 EKE39206.1 - 9.5e-05 22.0 0.4 0.0021 17.6 0.0 2.8 3 0 0 3 3 3 1 Rap/ran-GAP DHR-2 PF06920.13 EKE39207.1 - 5e-39 134.3 27.1 5e-39 134.3 27.1 3.5 1 1 1 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 EKE39207.1 - 8.3e-17 61.6 1.6 2.3e-16 60.2 1.6 1.8 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins PAP2 PF01569.21 EKE39208.1 - 7.4e-05 22.5 3.7 7.4e-05 22.5 3.7 1.8 1 1 1 2 2 2 1 PAP2 superfamily Phage_holin_5_2 PF16079.5 EKE39208.1 - 0.019 15.3 5.1 0.074 13.4 0.4 2.4 2 1 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V Phage_holin_4_2 PF04020.13 EKE39208.1 - 0.28 11.9 9.1 0.36 11.5 9.1 1.2 1 0 0 1 1 1 0 Mycobacterial 4 TMS phage holin, superfamily IV FUSC PF04632.12 EKE39208.1 - 0.38 9.2 2.8 0.4 9.2 2.8 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Raftlin PF15250.6 EKE39209.1 - 1.8 7.2 15.0 2 7.1 15.0 1.0 1 0 0 1 1 1 0 Raftlin NPR3 PF03666.13 EKE39209.1 - 2 7.1 14.3 2 7.1 14.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 EKE39209.1 - 4.3 5.6 12.0 4.9 5.4 12.0 1.0 1 0 0 1 1 1 0 Menin ALMT PF11744.8 EKE39209.1 - 6.5 5.5 15.8 7.1 5.3 15.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Vfa1 PF08432.10 EKE39209.1 - 6.7 7.0 24.5 10 6.4 24.5 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SMYLE_N PF18615.1 EKE39209.1 - 8 5.9 15.1 9.4 5.7 15.1 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain FAM60A PF15396.6 EKE39209.1 - 9 6.2 14.2 10 6.0 14.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A HIP1_clath_bdg PF16515.5 EKE39210.1 - 0.012 16.2 9.0 0.012 16.2 9.0 3.8 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF641 PF04859.12 EKE39210.1 - 0.013 15.9 12.5 0.013 15.9 12.5 2.8 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) DUF1722 PF08349.11 EKE39210.1 - 0.017 15.4 5.3 0.017 15.4 5.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) C1_1 PF00130.22 EKE39210.1 - 0.19 11.7 6.9 0.47 10.4 6.9 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TPR_MLP1_2 PF07926.12 EKE39210.1 - 0.31 11.1 33.8 0.065 13.3 8.3 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 EKE39210.1 - 0.39 10.8 35.7 0.055 13.5 19.4 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 C1_2 PF03107.16 EKE39210.1 - 0.49 10.7 5.8 1.3 9.4 5.8 1.7 1 0 0 1 1 1 0 C1 domain zf-RING_2 PF13639.6 EKE39210.1 - 1.1 9.7 6.3 3.5 8.0 6.3 2.0 1 0 0 1 1 1 0 Ring finger domain DUF1664 PF07889.12 EKE39210.1 - 4.1 7.5 17.7 1.2 9.2 8.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) GFD1 PF17331.2 EKE39210.1 - 5.4 7.3 10.2 2.8 8.2 6.2 2.8 2 0 0 2 2 2 0 GFD1 mRNA transport factor DUF948 PF06103.11 EKE39210.1 - 5.8 7.2 10.6 20 5.5 3.8 3.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) ADIP PF11559.8 EKE39210.1 - 7.6 6.6 33.6 1.2 9.2 8.5 2.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding AFT PF08731.11 EKE39211.1 - 3.3e-07 30.7 2.4 7.4e-07 29.6 2.4 1.6 1 0 0 1 1 1 1 Transcription factor AFT FAR1 PF03101.15 EKE39211.1 - 6.2e-05 23.6 5.5 0.00025 21.7 5.5 2.0 1 1 0 1 1 1 1 FAR1 DNA-binding domain Ephrin_rec_like PF07699.13 EKE39212.1 - 1.9e-59 197.2 133.7 4.3e-10 39.2 5.1 12.8 3 2 11 14 14 14 12 Putative ephrin-receptor like VSP PF03302.13 EKE39212.1 - 2e-10 40.1 78.4 0.00011 21.2 20.1 4.8 1 1 3 4 4 4 4 Giardia variant-specific surface protein TNFR_c6 PF00020.18 EKE39212.1 - 2.1e-05 24.8 96.6 0.47 10.9 0.3 13.9 5 4 4 11 11 11 6 TNFR/NGFR cysteine-rich region Orf78 PF06024.12 EKE39212.1 - 0.012 16.0 0.8 0.035 14.4 0.7 1.8 2 0 0 2 2 2 0 Orf78 (ac78) OAD_gamma PF04277.13 EKE39212.1 - 1.6 9.4 3.2 2.3 8.9 2.2 1.6 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain 7TM_GPCR_Srh PF10318.9 EKE39212.1 - 1.9 7.5 9.2 0.04 12.9 1.3 2.0 3 0 0 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Srh Sigma_reg_N PF13800.6 EKE39212.1 - 6.8 7.0 7.6 5.4 7.4 5.3 1.9 2 0 0 2 2 2 0 Sigma factor regulator N-terminal zf-RING_5 PF14634.6 EKE39213.1 - 2.5e-06 27.4 9.6 4.6e-06 26.5 9.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EKE39213.1 - 2.6e-06 27.4 5.9 2.6e-06 27.4 5.9 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EKE39213.1 - 1.2e-05 25.1 9.3 2e-05 24.4 9.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE39213.1 - 5e-05 23.1 13.8 0.00011 22.0 12.8 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE39213.1 - 0.00012 22.3 13.1 0.00012 22.3 13.1 1.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EKE39213.1 - 0.00014 21.7 10.8 0.00027 20.7 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EKE39213.1 - 0.00069 19.7 11.7 0.00082 19.5 9.5 2.2 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EKE39213.1 - 0.02 14.8 11.1 0.054 13.4 10.9 1.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EKE39213.1 - 4.1 7.2 8.5 1.1 9.0 2.9 2.7 2 0 0 2 2 2 0 RING-like zinc finger Las1 PF04031.13 EKE39214.1 - 6.6e-28 97.8 0.1 1.1e-27 97.1 0.1 1.4 1 0 0 1 1 1 1 Las1-like DUF1198 PF06711.11 EKE39214.1 - 0.068 13.2 0.3 1.4 9.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1198) DUF2067 PF09840.9 EKE39214.1 - 8.3 5.9 9.7 4.4 6.8 0.2 2.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2067) Pkinase_Tyr PF07714.17 EKE39216.1 - 3.3e-23 82.3 0.0 1.4e-22 80.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE39216.1 - 5.5e-16 58.7 0.0 3.7e-15 56.0 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EKE39216.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.4 1 1 0 1 1 1 0 Kinase-like TMEM154 PF15102.6 EKE39217.1 - 8.1e-05 22.6 0.3 8.1e-05 22.6 0.3 2.8 3 0 0 3 3 3 2 TMEM154 protein family Syndecan PF01034.20 EKE39217.1 - 0.015 15.2 2.1 0.015 15.2 2.1 1.9 2 0 0 2 2 2 0 Syndecan domain RIFIN PF02009.16 EKE39217.1 - 0.046 13.6 0.6 0.087 12.7 0.6 1.4 1 0 0 1 1 1 0 Rifin DUF4064 PF13273.6 EKE39217.1 - 0.047 14.0 2.4 0.073 13.4 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) CD34_antigen PF06365.12 EKE39217.1 - 0.064 12.8 0.4 0.15 11.6 0.4 1.6 1 0 0 1 1 1 0 CD34/Podocalyxin family Glycophorin_A PF01102.18 EKE39217.1 - 7.5 6.8 8.0 0.51 10.6 0.9 2.5 3 0 0 3 3 3 0 Glycophorin A HLH PF00010.26 EKE39218.1 - 0.0072 16.3 0.1 0.082 12.9 0.0 2.4 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Metallophos PF00149.28 EKE39219.1 - 0.029 14.9 0.0 0.052 14.0 0.0 1.5 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase HD PF01966.22 EKE39221.1 - 1.7e-15 57.3 0.8 3.8e-15 56.2 0.8 1.6 1 0 0 1 1 1 1 HD domain PDEase_I PF00233.19 EKE39221.1 - 0.0059 16.4 0.2 0.012 15.4 0.2 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Pneumo_M2 PF07380.11 EKE39221.1 - 0.028 14.7 0.5 0.19 12.0 0.0 2.6 2 0 0 2 2 2 0 Pneumovirus M2 protein BORA_N PF15280.6 EKE39221.1 - 0.065 12.9 0.8 3.4 7.3 0.0 2.9 3 0 0 3 3 3 0 Protein aurora borealis N-terminus Pyr_redox_2 PF07992.14 EKE39222.1 - 1.2e-20 74.0 0.3 1.5e-20 73.7 0.3 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EKE39222.1 - 2.2e-09 37.7 0.2 4.3e-09 36.8 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EKE39222.1 - 0.0044 16.3 0.2 0.0051 16.1 0.2 1.4 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EKE39222.1 - 0.029 13.4 1.2 0.091 11.8 0.0 2.1 1 1 2 3 3 3 0 FAD binding domain Pyr_redox_3 PF13738.6 EKE39222.1 - 0.15 11.3 0.2 0.3 10.3 0.1 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase CofC PF01983.16 EKE39223.1 - 0.00063 19.0 0.6 0.00084 18.6 0.6 1.2 1 0 0 1 1 1 1 Guanylyl transferase CofC like Luteo_Vpg PF01659.16 EKE39223.1 - 0.098 13.0 0.1 0.15 12.4 0.1 1.3 1 0 0 1 1 1 0 Luteovirus putative VPg genome linked protein PI3_PI4_kinase PF00454.27 EKE39224.1 - 5.8e-19 68.9 2.5 1.5e-18 67.6 2.5 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase C1_1 PF00130.22 EKE39225.1 - 6.2e-12 45.2 54.3 8.4e-07 28.8 11.9 4.5 4 0 0 4 4 4 3 Phorbol esters/diacylglycerol binding domain (C1 domain) DAGK_acc PF00609.19 EKE39225.1 - 5.7e-07 30.0 0.9 1.9e-06 28.3 0.2 2.3 2 1 0 2 2 2 1 Diacylglycerol kinase accessory domain PHD PF00628.29 EKE39225.1 - 0.0025 17.7 7.8 0.0025 17.7 7.8 4.3 4 1 1 5 5 5 2 PHD-finger C1_2 PF03107.16 EKE39225.1 - 0.0072 16.6 8.3 0.0072 16.6 8.3 4.3 4 1 1 5 5 5 3 C1 domain Zf_RING PF16744.5 EKE39225.1 - 0.6 10.3 35.6 0.47 10.6 4.5 3.9 3 0 0 3 3 3 0 KIAA1045 RING finger LRR_5 PF13306.6 EKE39226.1 - 1.9e-36 124.9 17.0 4.6e-22 78.3 5.2 2.5 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE39226.1 - 5.3e-08 32.5 0.3 0.0065 16.2 0.0 3.8 2 1 2 4 4 4 4 Leucine rich repeat Scm3 PF10384.9 EKE39227.1 - 0.0089 15.8 2.0 0.023 14.5 2.0 1.7 1 0 0 1 1 1 1 Centromere protein Scm3 PGA_cap PF09587.10 EKE39227.1 - 0.054 12.9 0.1 0.092 12.2 0.1 1.3 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap LsmAD PF06741.13 EKE39227.1 - 2 9.0 7.0 1.6 9.3 4.5 2.1 1 1 1 2 2 2 0 LsmAD domain Presenilin PF01080.17 EKE39228.1 - 1.5 7.5 3.2 2.2 7.0 3.2 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EKE39228.1 - 1.8 7.7 2.9 2.3 7.3 2.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RasGEF PF00617.19 EKE39229.1 - 6.1e-41 140.5 4.4 6.1e-41 140.5 4.4 2.6 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EKE39229.1 - 1.6e-06 28.2 0.0 1e-05 25.7 0.0 2.5 1 0 0 1 1 1 1 RasGEF N-terminal motif FAP206 PF12018.8 EKE39230.1 - 0.0036 16.9 8.8 0.0036 16.9 8.8 1.8 2 1 0 2 2 2 1 Domain of unknown function RRM_1 PF00076.22 EKE39230.1 - 0.0075 16.1 1.2 0.028 14.3 0.0 2.6 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sulfatase_C PF14707.6 EKE39230.1 - 0.088 13.5 0.6 2.3 9.0 0.1 2.6 2 1 0 2 2 2 0 C-terminal region of aryl-sulfatase DUF4922 PF16269.5 EKE39230.1 - 0.22 11.2 3.6 0.59 9.9 3.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4922) CutA1 PF03091.15 EKE39230.1 - 1.3 8.9 6.6 6.7 6.6 0.1 3.4 3 0 0 3 3 3 0 CutA1 divalent ion tolerance protein DUF508 PF04370.12 EKE39231.1 - 0.92 9.2 4.0 1.4 8.7 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF508) Ribosomal_S14 PF00253.21 EKE39232.1 - 3.6e-14 52.2 4.0 4.1e-14 52.1 4.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DZR PF12773.7 EKE39232.1 - 0.019 14.9 0.2 0.023 14.7 0.2 1.2 1 0 0 1 1 1 0 Double zinc ribbon Pox_Ag35 PF03286.14 EKE39233.1 - 2.8 7.7 25.5 6.8 6.4 25.5 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein IF4E PF01652.18 EKE39234.1 - 8.2e-25 87.5 0.7 1e-24 87.2 0.7 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E PUFD PF16553.5 EKE39235.1 - 0.014 15.5 0.5 0.048 13.8 0.1 2.1 2 1 0 2 2 2 0 BCORL-PCGF1-binding domain ProRS-C_2 PF09181.10 EKE39235.1 - 0.42 10.8 5.9 0.1 12.7 1.7 2.3 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal TLD PF07534.16 EKE39236.1 - 4.2e-29 101.6 0.2 8.7e-29 100.5 0.2 1.6 1 0 0 1 1 1 1 TLD BSD PF03909.17 EKE39236.1 - 1.7e-05 24.7 0.0 3.8e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 BSD domain EF-hand_7 PF13499.6 EKE39237.1 - 2.2e-23 82.5 5.1 2.1e-11 44.1 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EKE39237.1 - 2.9e-23 79.6 10.2 5.2e-08 31.9 0.1 4.6 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 EKE39237.1 - 5.4e-22 75.8 8.5 4.5e-08 32.4 0.1 4.7 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 EKE39237.1 - 3.2e-12 45.3 6.4 5.3e-06 25.7 0.3 3.5 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EKE39237.1 - 6.3e-12 45.2 5.6 3.3e-05 23.6 0.2 3.8 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 EKE39237.1 - 5.5e-11 42.6 0.3 0.00032 21.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EKE39237.1 - 5.3e-05 23.1 2.5 0.001 19.0 0.3 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand PhetRS_B1 PF18262.1 EKE39237.1 - 0.00063 19.9 5.2 0.27 11.5 0.3 3.1 1 1 2 3 3 3 2 Phe-tRNA synthetase beta subunit B1 domain SPARC_Ca_bdg PF10591.9 EKE39237.1 - 0.0012 19.1 1.3 0.55 10.6 0.2 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.10 EKE39237.1 - 0.002 18.2 3.4 0.012 15.7 0.2 2.4 2 1 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.13 EKE39237.1 - 0.0051 16.8 0.0 1.9 8.5 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) Caleosin PF05042.13 EKE39237.1 - 0.0056 16.6 1.2 4.9 7.0 0.1 3.0 1 1 2 3 3 3 1 Caleosin related protein EF-hand_14 PF17959.1 EKE39237.1 - 0.0088 16.4 0.8 5.2 7.5 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain EF-hand_11 PF08976.11 EKE39237.1 - 0.017 16.0 0.1 0.041 14.7 0.0 1.7 1 1 1 2 2 2 0 EF-hand domain RNA_pol_Rpb5_C PF01191.19 EKE39237.1 - 0.057 13.3 1.3 0.34 10.8 0.1 2.5 2 1 1 3 3 3 0 RNA polymerase Rpb5, C-terminal domain DUF2267 PF10025.9 EKE39237.1 - 0.066 13.5 0.1 0.34 11.2 0.1 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) HTH_19 PF12844.7 EKE39237.1 - 0.067 13.2 0.2 1.8 8.7 0.1 2.4 1 1 1 2 2 2 0 Helix-turn-helix domain DUF3887 PF13026.6 EKE39237.1 - 0.078 13.8 5.6 2.5 9.0 3.5 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3887) EF-hand_10 PF14788.6 EKE39237.1 - 0.18 11.7 3.8 20 5.1 0.0 3.7 4 0 0 4 4 4 0 EF hand AA_permease_2 PF13520.6 EKE39238.1 - 7.7e-33 113.9 40.3 1.2e-32 113.3 40.3 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EKE39238.1 - 8.7e-17 60.9 36.2 1.3e-16 60.3 36.2 1.1 1 0 0 1 1 1 1 Amino acid permease Rap_GAP PF02145.15 EKE39239.1 - 8.5e-68 227.6 0.4 1.7e-67 226.6 0.1 1.7 2 0 0 2 2 2 1 Rap/ran-GAP DUF4288 PF14119.6 EKE39239.1 - 0.063 13.7 3.7 2.7 8.5 3.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4288) DUF2118 PF09891.9 EKE39239.1 - 4.2 7.3 7.9 11 5.9 7.9 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) Ins134_P3_kin PF05770.11 EKE39241.1 - 1.6e-31 109.4 0.1 7.8e-31 107.2 0.1 1.9 1 1 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain RimK PF08443.11 EKE39241.1 - 4e-07 29.8 0.3 0.0071 16.0 0.1 2.2 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ABC_tran PF00005.27 EKE39242.1 - 2.8e-51 173.6 0.2 1.2e-27 97.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EKE39242.1 - 4.6e-46 157.7 53.2 3.4e-26 92.5 18.0 4.2 4 1 0 4 4 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EKE39242.1 - 1.8e-08 34.1 4.6 0.029 13.8 0.6 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EKE39242.1 - 0.00019 21.5 0.3 0.18 11.9 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase ATP-synt_ab PF00006.25 EKE39242.1 - 0.00033 20.4 0.3 0.051 13.2 0.0 3.1 3 0 0 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_22 PF13401.6 EKE39242.1 - 0.00084 19.6 1.2 0.98 9.7 0.0 3.5 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 EKE39242.1 - 0.0027 18.3 0.3 3.3 8.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EKE39242.1 - 0.0036 17.7 0.1 4.9 7.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 EKE39242.1 - 0.0064 16.0 1.6 1.8 8.0 0.1 2.8 3 0 0 3 3 3 2 P-loop containing dynein motor region DUF87 PF01935.17 EKE39242.1 - 0.015 15.4 2.5 0.083 13.0 0.1 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 EKE39242.1 - 0.016 15.1 0.1 4.9 7.0 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 EKE39242.1 - 0.066 13.0 0.8 0.87 9.4 0.0 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EKE39242.1 - 0.1 12.3 0.3 1.4 8.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain Metallophos PF00149.28 EKE39243.1 - 1.9e-33 116.7 0.1 3.3e-33 115.9 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE39243.1 - 0.067 13.4 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Peptidase_U57 PF05582.12 EKE39243.1 - 0.32 10.2 2.1 18 4.4 2.7 2.2 2 0 0 2 2 2 0 YabG peptidase U57 DUF1892 PF08987.10 EKE39243.1 - 0.63 10.2 5.9 0.94 9.7 3.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1892) Glyco_hydro_25 PF01183.20 EKE39244.1 - 1.9e-10 41.2 2.7 2.3e-10 41.0 2.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 DUF1906 PF08924.11 EKE39244.1 - 0.035 14.3 3.3 0.087 13.0 2.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1906) RRM_1 PF00076.22 EKE39245.1 - 2.9e-05 23.8 0.0 8e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) bZIP_1 PF00170.21 EKE39246.1 - 4.8e-06 26.6 19.2 4.8e-06 26.6 19.2 3.4 3 1 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.15 EKE39246.1 - 0.00024 21.1 14.9 0.00024 21.1 14.9 3.5 2 2 0 2 2 2 1 Basic region leucine zipper PRK PF00485.18 EKE39246.1 - 0.016 14.9 1.2 0.021 14.5 0.4 1.5 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family bZIP_Maf PF03131.17 EKE39246.1 - 0.018 15.5 13.6 0.018 15.5 13.6 1.9 1 1 1 2 2 2 0 bZIP Maf transcription factor TolA_bind_tri PF16331.5 EKE39246.1 - 0.04 14.0 9.5 0.2 11.7 6.6 2.3 1 1 1 2 2 2 0 TolA binding protein trimerisation DegS PF05384.11 EKE39246.1 - 0.1 12.1 15.1 0.15 11.6 15.1 1.3 1 1 0 1 1 1 0 Sensor protein DegS Bestrophin PF01062.21 EKE39246.1 - 1 8.7 4.0 1.3 8.4 4.0 1.1 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel FapA PF03961.13 EKE39246.1 - 1.5 7.3 14.7 1.7 7.1 14.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_23 PF13476.6 EKE39246.1 - 1.9 9.0 16.1 2.4 8.6 16.1 1.1 1 0 0 1 1 1 0 AAA domain DUF5320 PF17253.2 EKE39246.1 - 2.3 9.3 11.2 0.43 11.7 2.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5320) FlaC_arch PF05377.11 EKE39246.1 - 3.8 8.0 11.6 0.4 11.1 1.0 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) E2_bind PF08825.10 EKE39246.1 - 4.8 7.4 8.8 0.27 11.4 1.1 2.3 2 1 0 2 2 2 0 E2 binding domain ALMT PF11744.8 EKE39246.1 - 6 5.6 8.9 8 5.2 8.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter adh_short PF00106.25 EKE39247.1 - 1.4e-29 102.9 0.0 1.8e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EKE39247.1 - 8.2e-14 51.7 0.0 1.1e-13 51.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EKE39247.1 - 9.4e-07 28.5 0.3 2.5e-06 27.1 0.3 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EKE39247.1 - 8e-06 25.9 0.0 1.1e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EKE39247.1 - 0.005 16.0 0.2 0.0064 15.7 0.2 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein ApbA PF02558.16 EKE39247.1 - 0.0086 15.7 1.2 1.9 8.1 0.0 2.3 1 1 1 2 2 2 2 Ketopantoate reductase PanE/ApbA DUF1863 PF08937.11 EKE39247.1 - 0.064 13.6 0.5 5.3 7.4 0.1 2.4 2 0 0 2 2 2 0 MTH538 TIR-like domain (DUF1863) DUF1776 PF08643.10 EKE39247.1 - 0.12 11.7 5.0 0.4 10.0 5.0 1.8 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 EKE39247.1 - 0.2 11.5 0.0 0.51 10.2 0.0 1.7 2 0 0 2 2 2 0 NAD(P)H-binding TFIID_20kDa PF03847.13 EKE39248.1 - 2.1e-08 34.5 0.5 3.3e-08 33.9 0.5 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Ribosomal_S20p PF01649.18 EKE39248.1 - 0.065 13.9 0.1 0.14 12.8 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein S20 SapB_1 PF05184.15 EKE39249.1 - 0.043 13.8 1.6 0.11 12.5 1.0 2.1 2 0 0 2 2 2 0 Saposin-like type B, region 1 Cullin PF00888.22 EKE39250.1 - 8.7e-68 229.4 23.5 8.7e-68 229.4 23.5 1.7 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EKE39250.1 - 8.4e-19 67.4 4.6 8.4e-19 67.4 4.6 3.1 4 0 0 4 4 4 1 Cullin protein neddylation domain PIN_12 PF16289.5 EKE39250.1 - 0.002 18.6 1.9 0.002 18.6 1.9 4.4 4 3 1 5 5 5 1 PIN domain Ribosomal_S25 PF03297.15 EKE39250.1 - 0.14 12.4 4.1 0.34 11.1 4.1 1.7 1 0 0 1 1 1 0 S25 ribosomal protein Tubulin PF00091.25 EKE39251.1 - 2.2e-10 41.1 0.2 2.2e-10 41.1 0.2 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Sigma_reg_N PF13800.6 EKE39252.1 - 0.73 10.2 3.8 1.4 9.3 0.2 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal YtxH PF12732.7 EKE39254.1 - 0.087 13.4 20.6 1.2 9.7 8.7 4.3 2 1 1 3 3 3 0 YtxH-like protein DUF883 PF05957.13 EKE39254.1 - 0.24 12.0 6.0 3.3 8.4 0.1 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Mem_trans PF03547.18 EKE39255.1 - 0.79 8.1 7.1 0.83 8.0 7.1 1.0 1 0 0 1 1 1 0 Membrane transport protein AKAP95 PF04988.12 EKE39255.1 - 1.8 8.8 14.3 2.7 8.2 14.2 1.4 1 1 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) CDC45 PF02724.14 EKE39255.1 - 8.9 4.5 17.0 9.7 4.3 17.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Coiled-coil_56 PF09813.9 EKE39255.1 - 9.3 6.4 13.8 7 6.8 12.3 1.7 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 56 I_LWEQ PF01608.17 EKE39256.1 - 1.6e-26 93.4 8.9 4.5e-26 91.9 8.9 1.8 1 0 0 1 1 1 1 I/LWEQ domain ANTH PF07651.16 EKE39256.1 - 1.4e-22 80.0 0.1 1.4e-22 80.0 0.1 3.6 4 1 0 4 4 4 1 ANTH domain ENTH PF01417.20 EKE39256.1 - 0.00015 21.8 7.5 0.42 10.7 0.0 4.5 4 1 0 4 4 4 2 ENTH domain SbsC_C PF18058.1 EKE39256.1 - 0.012 15.8 0.4 0.012 15.8 0.4 2.8 3 0 0 3 3 3 0 SbsC C-terminal domain DUF2935 PF11155.8 EKE39256.1 - 0.57 10.5 12.4 2.6 8.4 1.1 4.2 3 2 0 3 3 3 0 Domain of unknown function (DUF2935) DHR10 PF18595.1 EKE39256.1 - 6.8 6.8 20.2 2.7 8.1 13.9 2.8 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain Sec7 PF01369.20 EKE39257.1 - 1.6e-29 102.9 0.1 7.5e-29 100.7 0.1 2.2 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EKE39257.1 - 5.1e-09 36.2 1.6 5.1e-09 36.2 1.6 4.0 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EKE39257.1 - 7.3e-06 25.7 2.7 0.00014 21.7 0.1 4.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) zf-MYND PF01753.18 EKE39257.1 - 0.00096 19.2 11.6 0.0023 18.0 11.6 1.7 1 0 0 1 1 1 1 MYND finger BORCS6 PF10157.9 EKE39257.1 - 0.22 11.7 1.6 17 5.6 0.1 3.2 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 6 Cation_efflux PF01545.21 EKE39258.1 - 1.5e-50 171.7 9.2 1.5e-50 171.7 9.2 2.4 3 0 0 3 3 3 1 Cation efflux family DIL PF01843.19 EKE39259.1 - 1.2e-05 25.5 0.0 4.4e-05 23.7 0.0 2.0 2 0 0 2 2 2 1 DIL domain NT-C2 PF10358.9 EKE39259.1 - 0.00061 19.5 7.0 0.00061 19.5 7.0 1.9 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins Phage_min_cap2 PF06152.11 EKE39259.1 - 1.4 7.8 5.6 0.46 9.3 0.1 2.1 2 1 0 2 2 2 0 Phage minor capsid protein 2 Ribosomal_S10 PF00338.22 EKE39260.1 - 9.8e-26 89.9 0.4 1.2e-25 89.5 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Cyt_c_ox_IV PF12270.8 EKE39261.1 - 0.025 14.7 9.4 0.059 13.5 4.9 2.0 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV PRA1 PF03208.19 EKE39261.1 - 8.7 6.0 10.7 16 5.1 10.7 1.4 1 1 0 1 1 1 0 PRA1 family protein adh_short PF00106.25 EKE39262.1 - 5.7e-28 97.7 0.0 2.5e-27 95.6 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EKE39262.1 - 9.7e-16 58.0 0.0 3e-15 56.4 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EKE39262.1 - 6e-05 23.0 0.0 7.7e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EKE39262.1 - 0.02 14.4 0.0 0.03 13.8 0.0 1.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family UDPG_MGDP_dh_N PF03721.14 EKE39262.1 - 0.062 12.9 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain EF1_GNE PF00736.19 EKE39263.1 - 1.3e-27 95.8 0.6 2e-27 95.2 0.6 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain BAR_3_WASP_bdg PF10456.9 EKE39263.1 - 0.062 12.8 2.0 1.8 8.0 0.4 2.0 1 1 1 2 2 2 0 WASP-binding domain of Sorting nexin protein C2 PF00168.30 EKE39264.1 - 8.7e-40 135.2 6.2 8.8e-23 80.6 0.1 3.4 3 1 0 3 3 3 2 C2 domain DOCK-C2 PF14429.6 EKE39264.1 - 0.049 13.4 0.8 0.5 10.1 0.2 2.3 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins XYPPX PF02162.17 EKE39264.1 - 0.68 9.8 101.0 0.11 12.3 9.9 8.5 7 1 1 8 8 8 0 XYPPX repeat (two copies) GBP PF02263.19 EKE39265.1 - 1e-29 103.6 1.8 1e-29 103.6 1.8 2.2 3 0 0 3 3 3 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 EKE39265.1 - 8.1e-05 22.7 0.9 0.00038 20.5 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase OAM_alpha PF16552.5 EKE39265.1 - 0.024 14.5 1.0 0.64 9.9 0.1 2.7 2 0 0 2 2 2 0 D-ornithine 4,5-aminomutase alpha-subunit Bcl-2 PF00452.19 EKE39265.1 - 0.057 14.1 0.4 15 6.4 0.1 3.9 3 0 0 3 3 3 0 Apoptosis regulator proteins, Bcl-2 family GIT1_C PF12205.8 EKE39265.1 - 2.2 8.4 10.3 0.22 11.7 1.1 3.1 2 1 1 3 3 3 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF1411 PF07199.11 EKE39266.1 - 0.076 12.7 0.1 0.1 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) ALG11_N PF15924.5 EKE39267.1 - 2.5e-73 246.6 5.2 4.3e-73 245.8 5.2 1.4 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EKE39267.1 - 1.4e-26 93.1 0.6 2.2e-26 92.4 0.6 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EKE39267.1 - 1.4e-13 51.4 0.0 2.1e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EKE39267.1 - 6e-05 23.4 0.0 0.00016 22.0 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 PRP1_N PF06424.12 EKE39268.1 - 1.1e-22 81.0 13.6 1.9e-16 60.8 11.4 2.6 1 1 1 2 2 2 2 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EKE39268.1 - 3.3e-13 49.2 0.0 0.66 11.0 0.0 7.6 7 2 2 9 9 9 2 Tetratricopeptide repeat TPR_2 PF07719.17 EKE39268.1 - 2.2e-08 33.6 0.8 0.0092 16.0 0.0 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EKE39268.1 - 1.7e-07 31.7 0.0 3.8 8.1 0.0 6.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 EKE39268.1 - 1.4e-05 24.9 6.1 0.15 12.3 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EKE39268.1 - 2e-05 23.9 20.3 0.093 11.8 0.8 4.8 4 1 1 5 5 5 4 NRDE-2, necessary for RNA interference TPR_15 PF13429.6 EKE39268.1 - 7.3e-05 22.1 0.0 0.1 11.8 0.0 3.9 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EKE39268.1 - 8.9e-05 22.1 1.8 0.047 13.5 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EKE39268.1 - 0.001 19.3 0.3 83 3.9 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 EKE39268.1 - 0.018 14.7 3.3 12 5.7 0.0 4.5 4 0 0 4 4 4 0 TPR repeat Peptidase_C1 PF00112.23 EKE39269.1 - 1.2e-05 25.6 1.6 0.11 12.5 0.2 2.7 2 1 0 2 2 2 2 Papain family cysteine protease VSP PF03302.13 EKE39270.1 - 8e-14 51.3 134.8 8.4e-07 28.2 37.9 5.2 1 1 3 4 4 4 3 Giardia variant-specific surface protein Latrotoxin_C PF15658.6 EKE39270.1 - 1.4 8.7 5.5 0.2 11.4 0.6 2.1 2 0 0 2 2 2 0 Latrotoxin C-terminal domain zf-UBR PF02207.20 EKE39271.1 - 1.4e-17 63.6 15.2 1.4e-17 63.6 15.2 3.9 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) zf-RING_2 PF13639.6 EKE39271.1 - 0.00048 20.4 2.1 0.00048 20.4 2.1 4.7 4 0 0 4 4 4 1 Ring finger domain zf-rbx1 PF12678.7 EKE39271.1 - 0.0025 18.1 4.5 0.0025 18.1 4.5 3.6 3 2 1 4 4 4 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EKE39271.1 - 0.0054 16.7 1.6 0.0054 16.7 1.6 4.7 4 1 0 4 4 4 1 zinc-RING finger domain DUF4580 PF15162.6 EKE39271.1 - 0.031 13.9 1.6 0.11 12.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4580) DUF1623 PF07785.11 EKE39271.1 - 7.1 6.9 7.7 0.35 11.1 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1623) Aminotran_5 PF00266.19 EKE39272.1 - 2.4e-47 161.7 0.0 3.9e-47 161.0 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V zf-C2H2_jaz PF12171.8 EKE39273.1 - 0.00047 20.4 2.2 0.0017 18.6 2.2 2.0 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EKE39273.1 - 0.004 17.9 0.7 0.019 15.8 0.7 2.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EKE39273.1 - 0.018 15.5 1.0 0.018 15.5 1.0 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type G-patch PF01585.23 EKE39273.1 - 0.021 14.7 0.0 0.051 13.5 0.0 1.7 1 0 0 1 1 1 0 G-patch domain zf_C2H2_ZHX PF18387.1 EKE39273.1 - 0.026 14.2 5.5 0.091 12.4 0.1 3.1 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain G-patch_2 PF12656.7 EKE39273.1 - 0.03 14.4 0.1 0.2 11.8 0.0 2.5 2 0 0 2 2 2 0 G-patch domain zf-RING_2 PF13639.6 EKE39273.1 - 0.1 12.9 4.8 0.3 11.5 4.8 1.8 1 0 0 1 1 1 0 Ring finger domain Velvet PF11754.8 EKE39273.1 - 0.25 11.3 5.3 0.41 10.6 0.0 2.1 2 0 0 2 2 2 0 Velvet factor Ribosomal_L19e PF01280.20 EKE39274.1 - 1.1e-45 155.3 7.2 1.5e-45 154.8 7.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L19e CorA PF01544.18 EKE39275.1 - 4.5e-49 167.3 3.2 6e-49 166.9 3.2 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 EKE39275.1 - 0.0062 15.4 3.5 0.0081 15.0 3.5 1.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) SWIRM PF04433.17 EKE39276.1 - 6.9e-22 77.6 0.8 1.8e-21 76.2 0.8 1.7 1 0 0 1 1 1 1 SWIRM domain RasGEF PF00617.19 EKE39277.1 - 2.5e-40 138.6 0.1 2.5e-40 138.6 0.1 2.6 4 0 0 4 4 4 1 RasGEF domain RasGEF_N PF00618.20 EKE39277.1 - 2.3e-11 43.8 2.4 8.8e-11 42.0 0.2 3.1 3 0 0 3 3 3 1 RasGEF N-terminal motif Caudo_bapla16 PF16792.5 EKE39277.1 - 0.0012 17.9 1.3 0.0068 15.5 0.6 2.1 1 1 1 2 2 2 1 Phage tail base-plate attachment protein of Caudovirales ORF16 PsbJ PF01788.17 EKE39278.1 - 0.42 10.5 3.7 0.96 9.4 2.1 2.3 1 1 1 2 2 2 0 PsbJ DUF2070 PF09843.9 EKE39278.1 - 7.3 4.7 19.1 8.4 4.5 19.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TLD PF07534.16 EKE39280.1 - 7.9e-11 42.3 1.3 1.3e-10 41.6 1.3 1.3 1 0 0 1 1 1 1 TLD PAP2_C PF14360.6 EKE39281.1 - 8.6e-12 45.4 15.1 8.6e-12 45.4 15.1 3.7 3 1 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EKE39281.1 - 1.8e-05 24.5 10.1 1.8e-05 24.5 10.1 2.4 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EKE39281.1 - 5.1 6.7 15.5 1.5 8.4 4.6 2.4 2 0 0 2 2 2 0 PAP2 superfamily Toprim_Crpt PF13342.6 EKE39283.1 - 0.067 13.2 0.1 0.22 11.5 0.1 1.9 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase CRR7 PF12095.8 EKE39283.1 - 0.59 10.6 4.2 1 9.8 0.0 3.9 4 0 0 4 4 4 0 Protein CHLORORESPIRATORY REDUCTION 7 CTD_bind PF04818.13 EKE39283.1 - 1.3 10.0 10.0 0.29 12.0 0.1 5.2 5 0 0 5 5 5 0 RNA polymerase II-binding domain. Peptidase_S74 PF13884.6 EKE39284.1 - 7.7e-15 55.0 0.1 2.1e-14 53.6 0.1 1.8 1 0 0 1 1 1 1 Chaperone of endosialidase DUF2339 PF10101.9 EKE39284.1 - 0.0015 17.3 0.0 0.0019 16.9 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2339) TctB PF07331.11 EKE39284.1 - 0.22 11.8 7.0 0.38 11.0 7.0 1.3 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family YL1 PF05764.13 EKE39285.1 - 2.7e-05 24.4 15.3 3e-05 24.3 15.3 1.1 1 0 0 1 1 1 1 YL1 nuclear protein BNIP2 PF12496.8 EKE39285.1 - 0.00054 20.4 4.5 0.00074 20.0 4.5 1.3 1 0 0 1 1 1 1 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 eIF3_subunit PF08597.10 EKE39285.1 - 0.0015 18.5 21.3 0.0023 17.9 21.3 1.3 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit RR_TM4-6 PF06459.12 EKE39285.1 - 0.066 13.0 9.3 0.064 13.1 9.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GAGA_bind PF06217.12 EKE39285.1 - 0.068 13.4 7.0 0.067 13.5 7.0 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family CDC45 PF02724.14 EKE39285.1 - 0.1 10.9 13.0 0.11 10.7 13.0 1.0 1 0 0 1 1 1 0 CDC45-like protein SspB PF04386.13 EKE39285.1 - 1.8 8.5 11.6 2.6 7.9 11.6 1.3 1 0 0 1 1 1 0 Stringent starvation protein B WD40 PF00400.32 EKE39286.1 - 2.3e-13 50.4 11.7 0.02 15.8 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE39286.1 - 5e-12 46.0 1.0 9.4e-05 22.6 0.0 3.7 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EKE39286.1 - 0.0029 16.6 0.8 1.6 7.6 0.1 2.9 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EKE39286.1 - 0.0064 16.4 2.6 0.061 13.2 1.3 3.1 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A RabGAP-TBC PF00566.18 EKE39288.1 - 5e-23 81.9 9.5 5e-23 81.9 9.5 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Takusan PF04822.13 EKE39288.1 - 0.57 10.1 2.5 0.87 9.5 0.2 2.5 2 0 0 2 2 2 0 Takusan DUF1505 PF07403.11 EKE39289.1 - 0.057 13.6 1.8 0.14 12.3 1.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1505) Sybindin PF04099.12 EKE39290.1 - 0.044 13.7 0.1 0.065 13.2 0.1 1.3 1 0 0 1 1 1 0 Sybindin-like family DBD_HTH PF18430.1 EKE39290.1 - 0.067 13.0 0.1 6.5 6.6 0.0 2.3 2 0 0 2 2 2 0 Putative DNA-binding domain EF-hand_7 PF13499.6 EKE39291.1 - 2.7e-26 91.8 24.8 2.4e-08 34.3 0.1 7.5 6 3 1 7 7 7 4 EF-hand domain pair EF-hand_1 PF00036.32 EKE39291.1 - 5.5e-15 53.7 23.9 0.0049 16.3 0.0 8.0 8 0 0 8 8 8 5 EF hand EF-hand_6 PF13405.6 EKE39291.1 - 3.5e-11 42.1 30.3 0.017 15.0 0.0 9.4 9 1 1 10 10 10 4 EF-hand domain EF-hand_8 PF13833.6 EKE39291.1 - 4.1e-08 32.9 21.0 0.022 14.6 0.1 7.6 8 1 0 8 8 8 4 EF-hand domain pair EF-hand_5 PF13202.6 EKE39291.1 - 2.9e-07 29.7 10.3 0.22 11.1 0.0 5.5 5 0 0 5 5 5 4 EF hand SPARC_Ca_bdg PF10591.9 EKE39291.1 - 0.0008 19.7 8.6 0.39 11.1 0.2 4.3 4 1 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region Protein_K PF12283.8 EKE39291.1 - 0.0083 16.3 0.1 7.6 6.8 0.0 2.6 2 0 0 2 2 2 2 Bacteriophage protein K SPO22 PF08631.10 EKE39291.1 - 0.015 14.8 3.4 0.13 11.8 0.3 2.8 3 0 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like EF-hand_10 PF14788.6 EKE39291.1 - 0.019 14.8 0.6 33 4.4 0.0 3.9 3 0 0 3 3 3 0 EF hand DUF2789 PF10982.8 EKE39291.1 - 0.22 11.7 1.4 10 6.4 0.0 4.0 4 1 0 4 4 4 0 Protein of unknown function (DUF2789) WH2 PF02205.20 EKE39292.1 - 0.00065 19.4 0.1 0.0014 18.3 0.1 1.6 1 0 0 1 1 1 1 WH2 motif DUF148 PF02520.17 EKE39292.1 - 0.015 15.4 0.5 0.052 13.7 0.5 1.9 1 0 0 1 1 1 0 Domain of unknown function DUF148 DUF3584 PF12128.8 EKE39292.1 - 0.034 11.7 3.6 0.041 11.4 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TACC_C PF05010.14 EKE39292.1 - 0.35 10.6 11.7 3.9 7.2 5.1 2.7 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal zf-CCCH PF00642.24 EKE39293.1 - 1.4e-12 47.2 4.9 7.6e-06 25.7 0.1 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EKE39293.1 - 3e-06 27.1 8.5 0.014 15.4 2.5 2.7 2 0 0 2 2 2 2 Zinc finger domain RRM_1 PF00076.22 EKE39293.1 - 4.1e-05 23.3 0.1 0.00011 21.9 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 EKE39293.1 - 0.0011 19.6 14.7 0.061 14.0 0.6 3.5 3 1 0 3 3 3 2 Torus domain zf-CCCH_4 PF18044.1 EKE39293.1 - 0.17 11.7 6.0 2.2 8.2 0.2 2.8 2 0 0 2 2 2 0 CCCH-type zinc finger Na_Ca_ex PF01699.24 EKE39294.1 - 3.7e-39 134.1 45.6 6.5e-20 71.6 19.8 2.5 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Halogen_Hydrol PF10112.9 EKE39294.1 - 0.075 13.1 0.1 0.075 13.1 0.1 3.2 4 0 0 4 4 4 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein GSHPx PF00255.19 EKE39294.1 - 0.095 12.3 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione peroxidase ST7 PF04184.12 EKE39294.1 - 1 7.7 6.1 0.078 11.4 1.2 1.5 2 0 0 2 2 2 0 ST7 protein IBN_N PF03810.19 EKE39295.1 - 2.1e-05 24.4 0.7 8.7e-05 22.4 0.7 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain Telomere_reg-2 PF10193.9 EKE39295.1 - 0.0011 19.3 3.9 0.14 12.6 0.2 4.0 3 1 1 4 4 4 2 Telomere length regulation protein RIX1 PF08167.12 EKE39295.1 - 0.0057 16.4 0.3 0.0057 16.4 0.3 5.3 4 1 1 5 5 5 1 rRNA processing/ribosome biogenesis Ras PF00071.22 EKE39296.1 - 4.5e-63 211.7 0.1 5.3e-63 211.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39296.1 - 5.9e-36 123.3 0.1 8.8e-36 122.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39296.1 - 1.3e-15 57.3 0.2 1.5e-15 57.1 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE39296.1 - 4.7e-08 32.7 0.1 5.6e-08 32.4 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE39296.1 - 1.8e-06 28.0 0.1 0.023 14.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE39296.1 - 2.3e-05 24.4 0.1 3.4e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE39296.1 - 5e-05 22.9 0.1 0.00013 21.6 0.1 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKE39296.1 - 0.00022 20.7 0.0 0.00027 20.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EKE39296.1 - 0.00077 19.9 0.0 0.0013 19.2 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain ATP_bind_1 PF03029.17 EKE39296.1 - 0.0016 18.3 0.1 0.014 15.2 0.0 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 EKE39296.1 - 0.0074 15.8 0.1 0.71 9.4 0.1 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_24 PF13479.6 EKE39296.1 - 0.0085 15.8 0.1 0.016 14.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 EKE39296.1 - 0.011 15.5 0.4 0.013 15.2 0.4 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EKE39296.1 - 0.014 15.7 0.0 0.052 13.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EKE39296.1 - 0.021 14.6 0.1 0.045 13.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 EKE39296.1 - 0.027 14.5 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Septin PF00735.18 EKE39296.1 - 0.03 13.6 0.1 0.062 12.6 0.1 1.5 1 1 0 1 1 1 0 Septin G-alpha PF00503.20 EKE39296.1 - 0.032 13.4 4.1 1.2 8.3 0.3 2.6 1 1 1 2 2 2 0 G-protein alpha subunit MCM PF00493.23 EKE39296.1 - 0.043 12.9 0.0 0.073 12.2 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain PduV-EutP PF10662.9 EKE39296.1 - 0.053 13.3 0.0 1.4 8.6 0.0 2.2 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 EKE39296.1 - 0.08 13.4 0.0 2.3 8.6 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF4238 PF14022.6 EKE39296.1 - 0.088 12.3 0.1 0.11 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) ABC_tran PF00005.27 EKE39296.1 - 0.11 13.1 1.4 0.22 12.0 1.4 1.7 1 1 0 1 1 1 0 ABC transporter DAP3 PF10236.9 EKE39296.1 - 0.13 11.4 0.0 0.38 9.9 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 LRR_9 PF14580.6 EKE39299.1 - 0.0075 15.8 4.4 0.092 12.2 1.2 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EKE39299.1 - 0.11 12.3 3.2 0.78 9.5 3.5 2.3 1 1 1 2 2 2 0 Leucine rich repeat LRR_4 PF12799.7 EKE39299.1 - 0.45 11.0 6.8 0.42 11.1 2.0 3.5 2 1 3 5 5 5 0 Leucine Rich repeats (2 copies) Pkinase PF00069.25 EKE39300.1 - 4e-72 242.8 0.0 4.5e-72 242.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39300.1 - 5.4e-33 114.4 0.0 6.9e-33 114.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EKE39300.1 - 9e-08 31.4 0.1 1.2e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EKE39300.1 - 0.0037 16.6 0.0 0.0042 16.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EKE39300.1 - 0.0062 15.6 0.0 0.0092 15.1 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 EKE39300.1 - 0.022 14.1 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EKE39300.1 - 0.091 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Acetyltransf_10 PF13673.7 EKE39301.1 - 3e-25 88.6 2.0 3.8e-25 88.3 2.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EKE39301.1 - 4.5e-15 55.9 0.1 5.2e-15 55.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EKE39301.1 - 7.5e-12 45.5 0.9 1.3e-11 44.8 0.9 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EKE39301.1 - 1.1e-05 26.2 0.0 1.4e-05 25.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EKE39301.1 - 1.1e-05 25.3 0.0 1.8e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EKE39301.1 - 0.00041 20.4 0.0 0.00072 19.6 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase PanZ PF12568.8 EKE39301.1 - 0.00059 19.6 0.0 0.00072 19.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Tipalpha PF16753.5 EKE39301.1 - 0.28 11.0 2.6 0.17 11.7 0.5 1.7 2 0 0 2 2 2 0 TNF-alpha-Inducing protein of Helicobacter Skp1 PF01466.19 EKE39303.1 - 5e-22 77.8 0.6 1.2e-21 76.5 0.6 1.7 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EKE39303.1 - 1.5e-14 53.9 0.4 1.5e-14 53.9 0.4 2.0 3 0 0 3 3 3 1 Skp1 family, tetramerisation domain Phage_int_SAM_5 PF13102.6 EKE39303.1 - 0.0035 17.6 0.4 0.022 15.1 0.0 2.1 2 0 0 2 2 2 1 Phage integrase SAM-like domain DUF615 PF04751.14 EKE39303.1 - 0.032 14.2 0.4 0.86 9.6 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF615) EMC1_C PF07774.13 EKE39305.1 - 0.011 15.4 0.1 0.022 14.5 0.1 1.5 1 0 0 1 1 1 0 ER membrane protein complex subunit 1, C-terminal Fn3_assoc PF13287.6 EKE39305.1 - 0.079 13.1 4.2 0.24 11.6 4.0 1.9 1 1 0 1 1 1 0 Fn3 associated NAP PF00956.18 EKE39306.1 - 4.1e-07 29.5 7.8 9.8e-07 28.2 7.8 1.7 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) RhoGEF PF00621.20 EKE39307.1 - 6.4e-34 117.8 2.4 6.4e-34 117.8 2.4 2.3 3 0 0 3 3 3 1 RhoGEF domain PI3K_rbd PF00794.18 EKE39308.1 - 3e-13 49.8 1.9 1.4e-10 41.3 0.1 3.6 3 0 0 3 3 3 1 PI3-kinase family, ras-binding domain PI3Ka PF00613.20 EKE39308.1 - 1.1e-12 47.8 4.1 3.3e-07 29.9 0.1 2.4 1 1 1 2 2 2 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 EKE39308.1 - 6.1e-07 29.4 0.4 7.5e-06 25.9 0.4 2.5 1 1 0 1 1 1 1 Phosphoinositide 3-kinase C2 Clat_adaptor_s PF01217.20 EKE39308.1 - 0.0018 18.2 0.9 0.0066 16.4 0.1 2.2 2 0 0 2 2 2 1 Clathrin adaptor complex small chain ELYS PF13934.6 EKE39308.1 - 0.029 14.4 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore complex assembly RA PF00788.23 EKE39308.1 - 0.069 13.8 0.0 0.26 11.9 0.0 2.0 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain DbpA PF03880.15 EKE39309.1 - 0.048 13.7 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 DbpA RNA binding domain Polysacc_deac_1 PF01522.21 EKE39310.1 - 2.7e-16 59.6 0.0 3.7e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF722 PF05263.11 EKE39310.1 - 0.14 12.4 0.2 4.9 7.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF722) Ras PF00071.22 EKE39311.1 - 3.7e-48 163.2 0.0 4.3e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39311.1 - 1.4e-34 118.9 0.1 1.9e-34 118.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39311.1 - 3.8e-19 68.8 0.0 4.7e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE39311.1 - 2.1e-07 31.0 0.1 3.4e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE39311.1 - 9.8e-07 28.4 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE39311.1 - 3.4e-06 26.7 0.1 0.00035 20.2 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE39311.1 - 4.3e-06 26.2 0.0 5.3e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EKE39311.1 - 4.7e-05 23.2 0.1 0.0012 18.6 0.1 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EKE39311.1 - 9.2e-05 22.7 0.0 0.01 16.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EKE39311.1 - 0.00017 22.0 0.0 0.00046 20.6 0.0 1.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EKE39311.1 - 0.0002 21.3 0.0 0.2 11.6 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 EKE39311.1 - 0.0012 18.4 0.0 0.0017 17.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EKE39311.1 - 0.0021 18.4 0.3 0.0082 16.5 0.1 2.2 2 1 0 2 2 2 1 RNA helicase AAA_16 PF13191.6 EKE39311.1 - 0.0034 17.8 0.0 0.0044 17.4 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EKE39311.1 - 0.007 16.4 0.0 0.019 15.0 0.0 1.7 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) Septin PF00735.18 EKE39311.1 - 0.0075 15.6 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Septin NTPase_1 PF03266.15 EKE39311.1 - 0.0091 15.9 0.0 0.7 9.8 0.0 2.1 1 1 0 2 2 2 1 NTPase ATP-synt_ab PF00006.25 EKE39311.1 - 0.0097 15.6 0.0 0.012 15.3 0.0 1.2 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain MCM PF00493.23 EKE39311.1 - 0.011 14.9 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain NACHT PF05729.12 EKE39311.1 - 0.016 15.2 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EKE39311.1 - 0.017 14.9 0.0 0.042 13.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 EKE39311.1 - 0.033 13.7 0.2 0.1 12.1 0.2 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF3067 PF11267.8 EKE39311.1 - 0.041 14.5 0.0 0.067 13.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3067) DUF87 PF01935.17 EKE39311.1 - 0.042 13.9 0.0 1.3 9.0 0.0 2.2 2 1 0 2 2 2 0 Helicase HerA, central domain G-alpha PF00503.20 EKE39311.1 - 0.044 12.9 0.2 5.6 6.0 0.1 2.2 1 1 1 2 2 2 0 G-protein alpha subunit Sigma54_activat PF00158.26 EKE39311.1 - 0.044 13.5 0.0 0.071 12.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 EKE39311.1 - 0.068 13.7 0.3 0.083 13.4 0.3 1.4 1 1 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 EKE39311.1 - 0.091 11.9 0.1 0.16 11.1 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain ATPase_2 PF01637.18 EKE39311.1 - 0.092 12.6 0.2 0.2 11.6 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TniB PF05621.11 EKE39311.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein nsp9 PF08710.10 EKE39312.1 - 0.065 13.6 0.3 0.16 12.4 0.3 1.6 1 0 0 1 1 1 0 nsp9 replicase Adaptin_N PF01602.20 EKE39313.1 - 2.2e-59 201.4 14.3 3.1e-59 200.9 14.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EKE39313.1 - 2.9e-09 37.2 1.0 1e-08 35.5 1.0 2.0 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EKE39313.1 - 8.7e-07 29.1 6.8 0.031 14.3 0.2 4.0 2 1 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKE39313.1 - 0.001 19.4 0.0 9 6.8 0.0 4.1 3 1 1 4 4 4 1 HEAT repeats HEAT PF02985.22 EKE39313.1 - 0.0014 18.8 0.0 15 6.2 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 EKE39313.1 - 0.0054 17.2 0.0 4.7 7.8 0.0 4.2 4 0 0 4 4 4 1 HEAT-like repeat Peptidase_C47 PF05543.13 EKE39313.1 - 0.019 14.6 0.4 5.6 6.5 0.0 3.5 3 0 0 3 3 3 0 Staphopain peptidase C47 Arm PF00514.23 EKE39313.1 - 0.033 14.2 0.0 33 4.7 0.0 3.8 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat REF PF05755.12 EKE39313.1 - 0.11 12.3 2.0 0.45 10.3 0.0 2.7 3 0 0 3 3 3 0 Rubber elongation factor protein (REF) TPR_1 PF00515.28 EKE39314.1 - 4e-21 73.9 9.1 1.2e-05 24.9 0.0 7.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 EKE39314.1 - 4.4e-20 70.1 14.2 1.8e-05 24.5 0.0 8.3 9 0 0 9 9 9 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE39314.1 - 2.3e-16 59.8 21.4 4.4e-05 23.6 0.0 5.5 3 3 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EKE39314.1 - 2.3e-14 52.3 6.2 9.7e-05 22.3 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EKE39314.1 - 2e-13 50.7 2.1 0.022 15.3 0.1 5.1 4 1 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EKE39314.1 - 1.1e-10 41.4 0.0 0.044 14.6 0.0 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKE39314.1 - 1.6e-09 37.3 0.4 0.11 12.2 0.0 5.6 5 1 1 6 6 6 2 TPR repeat TPR_7 PF13176.6 EKE39314.1 - 3.8e-09 35.9 0.9 0.0021 18.0 0.1 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EKE39314.1 - 5.2e-09 36.6 0.0 0.024 15.3 0.0 5.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EKE39314.1 - 7.5e-09 35.8 9.8 0.0052 17.1 0.0 6.6 6 2 1 7 7 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EKE39314.1 - 4.3e-08 33.3 2.0 0.86 10.4 0.1 5.6 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 EKE39314.1 - 8.3e-05 22.3 1.4 0.38 10.7 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EKE39314.1 - 0.00054 20.2 7.4 9.1 6.9 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 EKE39314.1 - 0.0021 18.2 0.0 1.6 8.9 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EKE39314.1 - 0.0095 16.0 3.4 2.3 8.3 0.0 3.6 2 1 1 3 3 3 1 Putative TPR-like repeat MASE1 PF05231.14 EKE39314.1 - 0.048 12.8 0.0 0.072 12.2 0.0 1.2 1 0 0 1 1 1 0 MASE1 DUF2225 PF09986.9 EKE39314.1 - 0.095 12.4 4.3 0.29 10.8 0.0 3.3 3 2 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) REV1_C PF16727.5 EKE39314.1 - 0.16 12.4 0.0 2.4 8.6 0.0 2.3 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Fis1_TPR_C PF14853.6 EKE39314.1 - 0.48 10.5 4.9 59 3.8 0.0 4.5 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Yip1 PF04893.17 EKE39315.1 - 0.02 14.6 19.4 0.032 14.0 19.4 1.4 1 1 0 1 1 1 0 Yip1 domain Swi3 PF07962.12 EKE39316.1 - 1.2e-11 44.4 0.2 1.4e-11 44.2 0.2 1.2 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 Ras PF00071.22 EKE39317.1 - 1.5e-11 44.2 7.1 5.8e-05 22.8 0.7 3.7 4 0 0 4 4 4 3 Ras family Roc PF08477.13 EKE39317.1 - 2.1e-08 34.4 0.6 0.00033 20.9 0.0 3.9 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EKE39317.1 - 6.1e-07 29.5 4.5 1e-06 28.8 0.5 3.0 4 0 0 4 4 4 1 50S ribosome-binding GTPase Arf PF00025.21 EKE39317.1 - 7.3e-06 25.6 3.3 0.0075 15.7 0.1 4.0 4 0 0 4 4 4 2 ADP-ribosylation factor family PH PF00169.29 EKE39317.1 - 8e-05 23.1 0.1 0.0003 21.2 0.1 2.0 1 0 0 1 1 1 1 PH domain PduV-EutP PF10662.9 EKE39317.1 - 0.00045 20.0 0.1 0.0022 17.7 0.1 2.3 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EKE39317.1 - 0.00096 19.1 3.5 0.0022 17.9 0.2 2.7 2 1 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 EKE39317.1 - 0.0015 18.1 0.2 0.0033 17.0 0.2 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region SRPRB PF09439.10 EKE39317.1 - 0.0036 16.8 1.4 0.01 15.2 0.0 2.4 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit PH_11 PF15413.6 EKE39317.1 - 0.011 16.1 0.1 0.054 13.9 0.1 2.3 1 0 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.5 EKE39317.1 - 0.066 13.0 1.9 0.12 12.2 0.1 2.3 3 1 0 3 3 3 0 Pleckstrin homology domain WD40 PF00400.32 EKE39318.1 - 5.2e-10 39.8 3.1 0.00088 20.0 0.1 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 EKE39318.1 - 1.2e-08 35.1 0.5 4.2e-08 33.3 0.2 2.0 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ERCC4 PF02732.15 EKE39319.1 - 4.4e-14 53.0 0.6 4.4e-14 53.0 0.6 2.9 3 0 0 3 3 3 1 ERCC4 domain Cmyb_C PF09316.10 EKE39320.1 - 0.02 14.6 2.2 0.024 14.3 0.2 2.1 2 0 0 2 2 2 0 C-myb, C-terminal FlbD PF06289.11 EKE39320.1 - 0.078 12.6 4.0 0.083 12.5 1.7 2.2 2 0 0 2 2 2 0 Flagellar and Swarming motility proteins DUF3349 PF11829.8 EKE39320.1 - 0.57 11.0 3.7 2.9 8.7 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3349) DUF737 PF05300.11 EKE39320.1 - 1.3 9.3 11.6 2.3 8.5 11.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF737) TPK_catalytic PF04263.16 EKE39321.1 - 2.6e-24 85.5 0.2 3.5e-24 85.2 0.2 1.1 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EKE39321.1 - 4.7e-13 48.6 0.2 9.9e-13 47.6 0.2 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Pkinase PF00069.25 EKE39322.1 - 6.3e-67 225.7 0.0 8e-67 225.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39322.1 - 3.1e-46 157.7 0.0 4.5e-46 157.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EKE39322.1 - 1.5e-09 38.1 0.0 8.9e-09 35.6 0.0 2.2 2 0 0 2 2 2 1 P21-Rho-binding domain PH PF00169.29 EKE39322.1 - 1.3e-08 35.3 0.1 2.9e-08 34.2 0.1 1.6 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 EKE39322.1 - 3.2e-06 26.2 0.0 4.9e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKE39322.1 - 0.00029 20.2 0.0 0.00054 19.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EKE39322.1 - 0.18 11.7 0.2 0.33 10.8 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ank_2 PF12796.7 EKE39324.1 - 2.9e-12 47.0 4.4 1.7e-07 31.7 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EKE39324.1 - 9.4e-11 41.7 3.7 0.0048 17.3 0.1 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EKE39324.1 - 7.3e-10 38.2 1.9 0.16 12.6 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EKE39324.1 - 1.9e-08 34.7 0.4 0.68 10.6 0.0 4.1 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE39324.1 - 2e-07 31.1 0.7 0.0089 16.3 0.1 3.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) RasGEF PF00617.19 EKE39325.1 - 1.7e-45 155.4 1.0 4.1e-45 154.2 1.0 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE39325.1 - 2.2e-12 47.1 1.8 2.6e-11 43.7 0.0 3.1 2 1 1 3 3 3 1 RasGEF N-terminal motif zf-RING_4 PF14570.6 EKE39325.1 - 0.084 12.7 6.9 0.21 11.4 6.8 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.6 EKE39325.1 - 0.3 11.5 10.8 0.6 10.5 10.8 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_3 PF13920.6 EKE39325.1 - 0.31 10.9 9.7 1.1 9.2 9.7 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE39325.1 - 0.57 10.1 10.8 2.3 8.2 10.9 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EKE39325.1 - 0.74 9.7 11.9 1.7 8.5 11.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 EKE39325.1 - 0.88 9.3 5.3 2.1 8.1 5.3 1.6 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_5 PF14634.6 EKE39325.1 - 1.2 9.1 8.7 3.9 7.5 8.7 1.8 1 1 1 2 2 2 0 zinc-RING finger domain zf-UDP PF14569.6 EKE39325.1 - 1.7 8.8 5.9 4.1 7.6 5.9 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger SecA_DEAD PF07517.14 EKE39326.1 - 0.093 12.0 1.9 0.11 11.8 1.9 1.1 1 0 0 1 1 1 0 SecA DEAD-like domain Med9 PF07544.13 EKE39326.1 - 0.27 11.3 4.3 0.47 10.6 2.5 2.0 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 zf-C4H2 PF10146.9 EKE39326.1 - 3.7 7.8 8.1 4.1 7.7 8.1 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein DUF2120 PF09893.9 EKE39327.1 - 0.01 16.0 4.8 0.012 15.7 4.8 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) SRP_SPB PF02978.19 EKE39327.1 - 0.014 16.0 2.1 0.019 15.6 2.0 1.5 1 1 0 1 1 1 0 Signal peptide binding domain DUF4954 PF16314.5 EKE39327.1 - 0.055 11.6 3.5 0.063 11.4 3.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Ku PF02735.16 EKE39328.1 - 2.1e-10 40.7 0.0 2.7e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain AAA_23 PF13476.6 EKE39329.1 - 0.065 13.7 9.6 0.082 13.4 9.6 1.1 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 EKE39329.1 - 1.7 7.3 8.4 2 7.1 8.4 1.1 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 EKE39329.1 - 2 7.7 5.0 2.2 7.5 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_11 PF13086.6 EKE39329.1 - 5.8 6.6 11.1 6.7 6.4 11.1 1.1 1 0 0 1 1 1 0 AAA domain SKICH PF17751.1 EKE39330.1 - 0.00024 21.6 0.8 0.1 13.1 0.2 2.5 2 0 0 2 2 2 2 SKICH domain HECW_N PF16562.5 EKE39330.1 - 0.011 15.6 0.1 2.3 8.1 0.1 2.5 1 1 1 2 2 2 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 DUF3244 PF11589.8 EKE39330.1 - 0.014 15.5 7.5 0.7 10.0 1.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3244) CLIP_1 PF18322.1 EKE39330.1 - 0.56 10.3 2.6 0.73 9.9 0.6 2.2 2 0 0 2 2 2 0 Serine protease Clip domain PPAF-2 DUF2838 PF10998.8 EKE39331.1 - 1.3e-37 128.5 7.6 1.3e-37 128.5 7.6 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF2838) dCMP_cyt_deam_1 PF00383.23 EKE39332.1 - 0.016 15.1 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region RET_CLD4 PF17813.1 EKE39335.1 - 0.82 10.0 4.3 0.67 10.3 0.1 2.8 2 1 0 2 2 2 0 RET Cadherin like domain 4 TIG PF01833.24 EKE39336.1 - 0.021 14.9 0.4 0.047 13.8 0.4 1.6 1 0 0 1 1 1 0 IPT/TIG domain Chromo PF00385.24 EKE39337.1 - 4e-09 36.2 4.3 4.4e-06 26.5 0.2 3.8 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain CM1 PF03026.15 EKE39337.1 - 0.059 12.7 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Influenza C virus M1 protein CH PF00307.31 EKE39338.1 - 3.5e-20 72.2 0.0 8.3e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain LIM PF00412.22 EKE39338.1 - 1.3e-11 44.5 6.7 1.9e-11 44.0 5.3 2.0 2 0 0 2 2 2 1 LIM domain CAMSAP_CH PF11971.8 EKE39338.1 - 2.2e-07 30.6 0.0 4.9e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain DZR PF12773.7 EKE39338.1 - 0.04 14.0 4.0 0.6 10.2 3.9 2.6 1 1 0 1 1 1 0 Double zinc ribbon C1_1 PF00130.22 EKE39338.1 - 0.081 12.8 7.3 0.18 11.7 2.6 2.7 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_2 PF13240.6 EKE39338.1 - 0.15 11.8 4.9 14 5.5 0.0 3.5 3 0 0 3 3 3 0 zinc-ribbon domain DUF2706 PF10913.8 EKE39338.1 - 0.74 9.7 2.7 5.8 6.8 0.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2706) LMBR1 PF04791.16 EKE39338.1 - 5.1 5.9 10.6 0.37 9.6 5.0 1.9 2 0 0 2 2 2 0 LMBR1-like membrane protein GFA PF04828.14 EKE39338.1 - 5.4 7.4 7.8 9.3 6.7 0.0 3.4 1 1 2 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme Roc PF08477.13 EKE39339.1 - 1.5e-11 44.6 0.2 2.1e-11 44.1 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EKE39339.1 - 4.5e-11 42.6 0.8 5.4e-11 42.4 0.8 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EKE39339.1 - 2.1e-06 27.3 0.1 2.4e-06 27.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE39339.1 - 0.00019 21.5 0.1 0.00024 21.2 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.6 EKE39339.1 - 0.0039 17.2 1.4 0.025 14.6 0.0 2.2 1 1 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 EKE39339.1 - 0.019 14.7 0.1 0.033 13.9 0.1 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EKE39339.1 - 0.026 14.2 0.2 0.042 13.6 0.2 1.5 1 1 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 EKE39339.1 - 0.027 13.8 0.1 0.03 13.7 0.1 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Flocculin_t3 PF13928.6 EKE39339.1 - 0.06 13.9 1.8 4.4 7.9 0.3 2.6 2 1 0 2 2 2 0 Flocculin type 3 repeat AAA_18 PF13238.6 EKE39339.1 - 0.081 13.5 0.2 0.17 12.4 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EKE39339.1 - 0.14 12.6 0.1 0.32 11.4 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF4633 PF15464.6 EKE39340.1 - 0.11 12.7 5.9 0.12 12.5 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4633) Alveol-reg_P311 PF11092.8 EKE39340.1 - 0.15 12.2 1.5 4.6 7.5 0.1 2.6 2 0 0 2 2 2 0 Neuronal protein 3.1 (p311) SF1-HH PF16275.5 EKE39342.1 - 4.1e-23 81.9 1.6 9.8e-23 80.6 1.6 1.6 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 EKE39342.1 - 1.6e-10 40.7 0.0 2.9e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 KH domain Rad1 PF02144.16 EKE39343.1 - 2.5e-10 39.9 5.1 1.4e-08 34.2 5.1 2.1 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 DUF5113 PF17140.4 EKE39343.1 - 0.085 12.7 1.6 3.6 7.4 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) HAD_2 PF13419.6 EKE39344.1 - 1.2e-10 41.7 0.0 1.5e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EKE39344.1 - 0.00042 20.3 0.0 0.0008 19.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EKE39344.1 - 0.0078 16.6 0.0 0.009 16.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKE39344.1 - 0.02 15.2 0.0 0.41 10.9 0.0 2.1 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Acetyltransf_9 PF13527.7 EKE39345.1 - 0.04 14.0 0.1 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain LRR_5 PF13306.6 EKE39346.1 - 7.4e-47 158.5 23.8 2.8e-26 92.0 11.3 2.4 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE39346.1 - 1.5e-13 50.3 0.1 0.00015 21.5 0.0 3.9 1 1 2 4 4 4 4 Leucine rich repeat DEAD PF00270.29 EKE39347.1 - 1.5e-32 112.8 0.2 2.6e-32 112.0 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE39347.1 - 2e-28 98.9 0.4 3.3e-27 95.0 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE39347.1 - 1e-06 28.9 0.0 1.7e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EKE39347.1 - 6.5e-06 25.7 0.0 1.3e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Pyridoxal_deC PF00282.19 EKE39348.1 - 2.6e-19 69.2 0.0 3.6e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EKE39348.1 - 8.8e-13 47.9 0.0 4.2e-12 45.7 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EKE39348.1 - 1.7e-05 23.5 0.0 3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SepSecS PF05889.13 EKE39348.1 - 0.06 12.0 2.7 0.056 12.1 0.3 2.1 3 0 0 3 3 3 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 EKE39348.1 - 0.16 11.2 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase VHS PF00790.19 EKE39349.1 - 0.00034 20.5 2.0 0.00067 19.5 0.2 2.4 1 1 2 3 3 3 1 VHS domain GIT1_C PF12205.8 EKE39349.1 - 0.063 13.4 0.5 0.71 10.0 0.2 2.5 2 1 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term KMP11 PF03037.16 EKE39349.1 - 0.48 11.2 2.8 1.2 10.0 0.8 2.6 1 1 1 2 2 2 0 Kinetoplastid membrane protein 11 TLD PF07534.16 EKE39352.1 - 8.6e-08 32.5 1.2 1.7e-07 31.5 1.2 1.7 1 1 0 1 1 1 1 TLD Mt_ATP-synt_D PF05873.12 EKE39352.1 - 0.014 15.3 8.3 0.025 14.4 8.2 1.5 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Viral_Rep PF02407.16 EKE39352.1 - 0.015 15.5 0.0 0.043 14.1 0.0 1.7 1 0 0 1 1 1 0 Putative viral replication protein Occludin_ELL PF07303.13 EKE39352.1 - 0.83 10.4 11.4 0.13 13.0 2.4 2.3 1 1 1 2 2 2 0 Occludin homology domain KxDL PF10241.9 EKE39352.1 - 1.4 9.3 7.2 1.8 8.9 1.1 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF2524 PF10732.9 EKE39352.1 - 1.6 9.1 6.4 0.5 10.7 3.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) DUF641 PF04859.12 EKE39352.1 - 3.8 7.8 7.7 2.5 8.4 3.4 2.4 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) TF_Zn_Ribbon PF08271.12 EKE39353.1 - 8.8e-05 21.9 0.5 0.00021 20.7 0.5 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding TFIIB PF00382.19 EKE39353.1 - 0.00015 21.8 0.6 0.8 9.8 0.0 2.8 3 0 0 3 3 3 2 Transcription factor TFIIB repeat CaM-KIIN PF15170.6 EKE39353.1 - 0.034 14.3 0.1 0.66 10.2 0.1 2.4 2 0 0 2 2 2 0 Calcium/calmodulin-dependent protein kinase II inhibitor Retro_M PF02813.14 EKE39353.1 - 0.039 14.3 0.0 0.073 13.5 0.0 1.4 1 0 0 1 1 1 0 Retroviral M domain Utp12 PF04003.12 EKE39353.1 - 0.2 12.0 0.9 0.36 11.2 0.1 1.8 2 0 0 2 2 2 0 Dip2/Utp12 Family PyrI_C PF02748.15 EKE39353.1 - 0.38 10.7 9.2 0.18 11.8 1.3 2.9 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Zn_ribbon_SprT PF17283.2 EKE39353.1 - 8.2 6.4 8.8 0.93 9.5 1.2 2.6 2 0 0 2 2 2 0 SprT-like zinc ribbon domain PAP2 PF01569.21 EKE39354.1 - 2.6e-23 82.3 5.1 2.6e-23 82.3 5.1 1.8 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EKE39354.1 - 0.18 11.5 11.6 1.3 8.7 5.2 3.0 2 1 0 2 2 2 0 PAP2 superfamily Sigma_reg_N PF13800.6 EKE39354.1 - 0.49 10.7 2.9 4.1 7.8 0.6 3.1 2 1 1 3 3 3 0 Sigma factor regulator N-terminal Sld5 PF05916.11 EKE39355.1 - 0.052 14.0 0.3 0.11 12.9 0.3 1.5 1 0 0 1 1 1 0 GINS complex protein HSF_DNA-bind PF00447.17 EKE39356.1 - 1.5e-25 89.6 1.2 1.5e-25 89.6 1.2 2.4 2 1 0 2 2 2 1 HSF-type DNA-binding Smg4_UPF3 PF03467.15 EKE39357.1 - 1.2e-11 45.0 0.3 1.3e-11 44.8 0.3 1.1 1 0 0 1 1 1 1 Smg-4/UPF3 family Ras PF00071.22 EKE39358.1 - 2.6e-52 176.7 0.2 3.1e-52 176.4 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39358.1 - 1.9e-17 63.6 0.9 3.1e-17 62.9 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39358.1 - 4.8e-09 35.9 0.1 6.2e-09 35.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE39358.1 - 4.5e-07 29.6 0.0 2.2e-06 27.4 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE39358.1 - 0.00051 20.1 0.5 0.002 18.2 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE39358.1 - 0.0036 17.2 1.0 0.11 12.4 0.0 2.3 1 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EKE39358.1 - 0.014 15.0 0.3 0.13 11.8 0.3 2.3 1 1 0 1 1 1 0 Ferrous iron transport protein B DUF4485 PF14846.6 EKE39358.1 - 0.058 13.4 0.2 0.11 12.6 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) LpoB PF13036.6 EKE39358.1 - 0.1 12.5 2.7 0.23 11.4 2.7 1.5 1 0 0 1 1 1 0 Peptidoglycan-synthase activator LpoB ORC_WH_C PF18137.1 EKE39358.1 - 0.11 12.6 1.7 0.16 12.1 1.7 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal IBR PF01485.21 EKE39359.1 - 1.9e-09 37.6 50.7 2e-05 24.7 9.0 4.0 3 1 0 3 3 3 3 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 EKE39359.1 - 1.2e-06 28.5 2.6 1.2e-06 28.5 2.6 3.8 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EKE39359.1 - 1.1e-05 25.1 2.4 1.1e-05 25.1 2.4 4.2 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE39359.1 - 0.0034 17.7 9.8 0.0034 17.7 9.8 5.0 5 2 0 5 5 5 1 Ring finger domain zf-Nse PF11789.8 EKE39359.1 - 0.41 10.5 10.1 1.8 8.4 2.7 3.4 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit Rap_GAP PF02145.15 EKE39360.1 - 4.2e-60 202.5 0.7 7.4e-60 201.7 0.1 1.7 2 0 0 2 2 2 1 Rap/ran-GAP DSPc PF00782.20 EKE39361.1 - 1.3e-22 80.0 0.4 1.3e-22 80.0 0.4 2.6 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EKE39361.1 - 8.8e-07 29.2 6.8 8.8e-07 29.2 6.8 2.5 2 1 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EKE39361.1 - 0.0069 16.4 0.0 0.018 15.0 0.0 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family PRK PF00485.18 EKE39363.1 - 4.3e-45 153.9 0.1 5.7e-45 153.5 0.1 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EKE39363.1 - 1.3e-05 25.8 0.0 2.2e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EKE39363.1 - 0.00068 19.8 0.0 0.0014 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EKE39363.1 - 0.0063 15.8 0.0 0.013 14.8 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin CoaE PF01121.20 EKE39363.1 - 0.016 14.9 0.0 0.088 12.5 0.0 2.0 2 0 0 2 2 2 0 Dephospho-CoA kinase dNK PF01712.19 EKE39363.1 - 0.016 15.1 0.2 0.054 13.3 0.2 1.8 1 1 0 1 1 1 0 Deoxynucleoside kinase AAA_14 PF13173.6 EKE39363.1 - 0.041 13.9 0.1 3.2 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EKE39363.1 - 0.046 12.8 0.0 0.075 12.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 EKE39363.1 - 0.082 12.6 0.1 1.6 8.4 0.0 2.4 3 0 0 3 3 3 0 Cytidylate kinase RRM_1 PF00076.22 EKE39364.1 - 4.1e-28 97.0 0.4 9.5e-14 51.0 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EKE39364.1 - 1.5e-05 25.4 3.3 0.24 11.6 0.0 3.4 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter DAN PF03045.15 EKE39364.1 - 0.003 17.6 0.3 1.3 9.1 0.0 2.4 1 1 1 2 2 2 2 DAN domain Nup35_RRM_2 PF14605.6 EKE39364.1 - 0.0093 15.9 0.1 0.93 9.5 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif P3A PF08727.11 EKE39364.1 - 0.05 13.0 0.2 0.7 9.3 0.0 2.4 2 0 0 2 2 2 0 Poliovirus 3A protein like RL PF17797.1 EKE39364.1 - 0.053 13.5 0.1 5.9 6.9 0.0 2.9 3 0 0 3 3 3 0 RL domain RRM_Rrp7 PF17799.1 EKE39364.1 - 0.079 12.8 0.2 0.2 11.5 0.2 1.7 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain HALZ PF02183.18 EKE39365.1 - 0.2 11.9 0.2 0.2 11.9 0.2 4.8 6 1 0 6 6 6 0 Homeobox associated leucine zipper DUF5320 PF17253.2 EKE39365.1 - 0.41 11.8 0.1 0.41 11.8 0.1 4.9 4 2 1 5 5 5 0 Family of unknown function (DUF5320) DUF4828 PF16110.5 EKE39365.1 - 0.79 10.2 7.3 0.18 12.3 1.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4828) NAP PF00956.18 EKE39366.1 - 7.4e-16 58.1 2.8 7.4e-16 58.1 2.8 1.5 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) TLD PF07534.16 EKE39367.1 - 1.9e-08 34.6 2.7 3.3e-08 33.9 2.7 1.3 1 0 0 1 1 1 1 TLD R3H PF01424.22 EKE39368.1 - 0.066 13.2 0.2 0.34 10.9 0.1 2.2 2 0 0 2 2 2 0 R3H domain CCDC-167 PF15188.6 EKE39369.1 - 0.0012 19.2 2.1 0.0012 19.2 2.1 1.7 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 167 DUF4179 PF13786.6 EKE39369.1 - 0.0065 16.9 0.0 0.0088 16.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4179) M PF02370.16 EKE39369.1 - 1.4 9.8 5.9 26 5.8 0.3 2.6 2 0 0 2 2 2 0 M protein repeat PTPA PF03095.15 EKE39370.1 - 9.9e-106 353.6 0.2 1.1e-105 353.4 0.2 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Plus-3 PF03126.18 EKE39371.1 - 1.6e-06 28.6 0.1 1.6e-06 28.6 0.1 2.4 2 1 0 2 2 2 1 Plus-3 domain GST_C_3 PF14497.6 EKE39371.1 - 0.12 12.5 1.8 0.46 10.7 0.1 2.6 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain Aa_trans PF01490.18 EKE39372.1 - 7.6e-18 64.4 30.9 1.2e-17 63.7 30.9 1.3 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein LRR_5 PF13306.6 EKE39374.1 - 3.7e-62 208.0 52.9 1.2e-28 99.6 12.4 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE39374.1 - 1.5e-08 34.3 9.9 0.0032 17.2 0.1 6.4 2 2 6 8 8 8 4 Leucine rich repeat Ras PF00071.22 EKE39375.1 - 3.2e-52 176.4 0.8 3.8e-52 176.2 0.8 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39375.1 - 9.1e-33 113.0 0.3 1.4e-32 112.4 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39375.1 - 6.3e-21 74.6 0.1 8.7e-21 74.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE39375.1 - 4.2e-07 29.7 0.0 7.3e-06 25.6 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE39375.1 - 8.3e-07 29.1 0.0 1.4e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE39375.1 - 1e-05 25.0 0.2 1.4e-05 24.6 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE39375.1 - 3.5e-05 23.8 0.0 0.00022 21.2 0.0 2.0 1 1 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EKE39375.1 - 0.0014 18.1 0.0 0.0023 17.4 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EKE39375.1 - 0.01 15.3 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 EKE39375.1 - 0.013 15.0 0.0 0.072 12.6 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B TniB PF05621.11 EKE39375.1 - 0.014 14.8 0.0 0.027 13.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.29 EKE39375.1 - 0.05 14.0 0.0 0.16 12.4 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1_Xtn PF16897.5 EKE39375.1 - 0.056 13.5 0.0 0.17 11.9 0.0 1.8 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RhoGAP PF00620.27 EKE39376.1 - 2.2e-21 76.2 0.0 9.9e-21 74.2 0.0 2.2 1 0 0 1 1 1 1 RhoGAP domain DNAJ_related PF12339.8 EKE39376.1 - 0.06 13.6 1.3 0.13 12.5 0.1 2.2 2 0 0 2 2 2 0 DNA-J related protein LON_substr_bdg PF02190.16 EKE39376.1 - 0.57 10.0 5.7 1 9.2 1.0 2.7 2 1 0 2 2 2 0 ATP-dependent protease La (LON) substrate-binding domain adh_short PF00106.25 EKE39377.1 - 6.8e-39 133.3 0.0 9.6e-39 132.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EKE39377.1 - 3e-22 79.4 0.0 4e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EKE39377.1 - 0.00032 20.2 0.1 0.00073 19.1 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EKE39377.1 - 0.0008 19.7 0.0 0.0018 18.6 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EKE39377.1 - 0.0049 16.1 0.0 0.007 15.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EKE39377.1 - 0.0056 16.6 0.0 0.01 15.8 0.0 1.5 1 1 0 1 1 1 1 KR domain Ribosomal_L12_N PF16320.5 EKE39377.1 - 0.019 14.7 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain 3HCDH_N PF02737.18 EKE39377.1 - 0.04 13.8 0.1 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EKE39377.1 - 0.053 12.9 0.2 0.1 11.9 0.0 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 EKE39377.1 - 0.12 13.0 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EKE39377.1 - 0.15 11.4 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Aa_trans PF01490.18 EKE39379.1 - 1.4e-15 57.0 42.9 7.3e-15 54.6 42.9 2.1 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Arc_PepC_II PF06847.11 EKE39379.1 - 0.0099 16.4 0.0 0.023 15.2 0.0 1.6 1 0 0 1 1 1 1 Archaeal Peptidase A24 C-terminus Type II Nuc_recep-AF1 PF11825.8 EKE39379.1 - 0.69 10.0 4.2 5.5 7.1 0.0 2.7 3 0 0 3 3 3 0 Nuclear/hormone receptor activator site AF-1 Herpes_UL42 PF02282.16 EKE39380.1 - 0.043 13.7 0.1 0.42 10.5 0.0 2.2 3 0 0 3 3 3 0 DNA polymerase processivity factor (UL42) DEAD PF00270.29 EKE39381.1 - 3.7e-49 166.9 0.5 8.4e-49 165.7 0.5 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE39381.1 - 3.3e-24 85.4 0.5 4.2e-23 81.8 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EKE39381.1 - 9e-16 57.9 0.0 1.8e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EKE39381.1 - 8.9e-09 35.6 0.1 8.9e-09 35.6 0.1 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EKE39381.1 - 0.029 14.7 0.0 0.077 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.19 EKE39381.1 - 0.057 12.8 0.0 1.9 7.8 0.2 2.3 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain IBR PF01485.21 EKE39382.1 - 9e-13 48.3 50.5 4.8e-05 23.5 11.6 5.5 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 EKE39382.1 - 1.4e-07 31.3 4.7 1.4e-07 31.3 4.7 6.7 4 2 0 5 5 5 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EKE39382.1 - 1.1e-06 28.5 3.4 1.1e-06 28.5 3.4 4.3 3 1 0 3 3 3 1 RING-type zinc-finger RWD PF05773.22 EKE39382.1 - 8.6e-05 22.8 1.7 0.0003 21.1 1.7 1.9 1 0 0 1 1 1 1 RWD domain zf-C3HC4 PF00097.25 EKE39382.1 - 0.00012 21.9 1.4 0.00012 21.9 1.4 6.0 3 2 2 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE39382.1 - 0.00015 22.0 3.2 0.00015 22.0 3.2 5.5 4 2 1 5 5 5 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKE39382.1 - 0.0032 17.3 1.8 0.0032 17.3 1.8 6.4 5 2 2 7 7 7 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE39382.1 - 0.007 16.2 3.8 0.007 16.2 3.8 6.2 5 1 1 6 6 6 1 Prokaryotic RING finger family 4 DUF2971 PF11185.8 EKE39384.1 - 1.6 9.9 9.0 1.2 10.4 0.8 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF2971) V-SNARE_C PF12352.8 EKE39385.1 - 3.7e-09 36.7 3.6 1.2e-08 35.1 3.4 1.8 1 1 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EKE39385.1 - 6.2e-07 29.2 0.7 9.1e-07 28.7 0.7 1.3 1 0 0 1 1 1 1 Sec20 DUF5089 PF17002.5 EKE39385.1 - 8.8e-06 25.7 0.4 9.6e-06 25.6 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5089) GAS PF13851.6 EKE39385.1 - 0.0061 15.9 2.3 0.0076 15.6 2.3 1.0 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Use1 PF09753.9 EKE39385.1 - 0.0084 15.9 0.5 0.011 15.5 0.3 1.3 1 1 0 1 1 1 1 Membrane fusion protein Use1 DUF724 PF05266.14 EKE39385.1 - 0.04 13.7 2.2 0.047 13.5 2.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Fusion_gly PF00523.18 EKE39385.1 - 0.079 11.2 2.5 0.15 10.3 2.5 1.5 1 1 0 1 1 1 0 Fusion glycoprotein F0 ETRAMP PF09716.10 EKE39385.1 - 0.23 11.6 2.6 0.46 10.6 2.6 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) ASFV_J13L PF05568.11 EKE39385.1 - 0.58 9.9 6.4 5.8 6.6 3.4 2.0 2 0 0 2 2 2 0 African swine fever virus J13L protein Synaptobrevin PF00957.21 EKE39385.1 - 0.68 9.8 5.5 0.99 9.2 5.1 1.5 1 1 0 1 1 1 0 Synaptobrevin Insulin_TMD PF17870.1 EKE39385.1 - 0.7 10.0 8.2 1.1 9.4 8.2 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment UPF0767 PF15990.5 EKE39385.1 - 0.99 9.6 3.4 0.33 11.1 0.9 1.6 1 1 1 2 2 2 0 UPF0767 family MFS_1 PF07690.16 EKE39386.1 - 2.3e-36 125.5 59.1 2.8e-30 105.5 34.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EKE39386.1 - 1.2e-15 57.3 18.9 3.2e-13 49.3 17.3 2.8 1 1 1 2 2 2 2 Sugar (and other) transporter Zip PF02535.22 EKE39387.1 - 8e-33 114.1 21.6 1.2e-29 103.7 21.6 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter Dynamin_M PF01031.20 EKE39388.1 - 4.6e-82 275.4 7.5 4.6e-82 275.4 7.5 2.1 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 EKE39388.1 - 2.3e-52 177.4 0.2 2.3e-52 177.4 0.2 2.2 2 1 0 2 2 2 1 Dynamin family GED PF02212.18 EKE39388.1 - 4.4e-30 103.7 4.0 1.2e-29 102.3 4.0 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EKE39388.1 - 2.7e-06 27.5 0.1 2e-05 24.6 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EKE39388.1 - 0.011 15.0 1.6 0.8 9.0 0.0 2.9 3 0 0 3 3 3 0 AIG1 family FeoB_N PF02421.18 EKE39388.1 - 0.015 14.8 1.0 1.1 8.8 0.2 2.9 3 0 0 3 3 3 0 Ferrous iron transport protein B CNDH2_C PF16858.5 EKE39388.1 - 0.049 13.5 0.7 0.61 9.9 0.0 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DnaI_N PF07319.11 EKE39388.1 - 0.067 13.9 2.8 7.2 7.4 0.3 3.0 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus FAA_hydrolase_N PF09298.11 EKE39388.1 - 0.35 11.1 4.0 11 6.3 0.1 3.9 4 1 1 5 5 5 0 Fumarylacetoacetase N-terminal Fzo_mitofusin PF04799.13 EKE39388.1 - 1.1 8.8 4.3 18 4.8 0.4 2.6 2 0 0 2 2 2 0 fzo-like conserved region Pap_E4 PF02711.14 EKE39388.1 - 4.3 8.4 8.1 9.2 7.3 8.1 1.5 1 0 0 1 1 1 0 E4 protein LAGLIDADG_1 PF00961.19 EKE39388.1 - 6 7.9 7.7 0.38 11.8 0.3 2.9 3 1 1 4 4 4 0 LAGLIDADG endonuclease Myosin_head PF00063.21 EKE39390.1 - 2.3e-255 849.0 0.8 2.8e-255 848.7 0.8 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EKE39390.1 - 1.7e-40 138.7 1.3 3e-40 137.9 1.3 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EKE39390.1 - 4.2e-18 64.7 0.7 9.5e-18 63.6 0.7 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EKE39390.1 - 1.4e-16 60.1 0.2 4e-16 58.6 0.2 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EKE39390.1 - 6.5e-15 54.5 0.1 2.8e-14 52.5 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain DUF2075 PF09848.9 EKE39390.1 - 0.0025 17.1 0.1 0.0041 16.4 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SH3_3 PF08239.11 EKE39390.1 - 0.0054 17.0 1.2 0.013 15.7 1.2 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain RsgA_GTPase PF03193.16 EKE39390.1 - 0.0098 15.8 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_10 PF12846.7 EKE39390.1 - 0.01 14.8 0.1 0.019 13.9 0.1 1.4 1 0 0 1 1 1 0 AAA-like domain Sigma54_activat PF00158.26 EKE39390.1 - 0.016 15.0 0.1 0.16 11.7 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.6 EKE39390.1 - 0.016 15.6 0.0 0.035 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 EKE39390.1 - 0.027 14.8 1.3 0.19 12.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 EKE39390.1 - 0.03 14.2 0.0 0.08 12.9 0.0 1.7 1 0 0 1 1 1 0 NACHT domain IQ PF00612.27 EKE39390.1 - 0.046 13.5 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif AAA_22 PF13401.6 EKE39390.1 - 0.067 13.5 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 EKE39390.1 - 0.17 12.0 0.0 0.47 10.5 0.0 1.8 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain His_Phos_2 PF00328.22 EKE39391.1 - 5.5e-24 85.2 1.8 2.2e-23 83.2 1.8 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RhoGEF PF00621.20 EKE39392.1 - 1.9e-35 122.8 6.5 4.3e-35 121.6 6.5 1.6 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 EKE39392.1 - 4.9e-16 58.6 9.9 1.1e-15 57.5 9.9 1.6 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EKE39392.1 - 1.1e-14 54.8 0.2 3e-14 53.4 0.0 1.9 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EKE39392.1 - 0.02 15.3 0.1 0.16 12.4 0.0 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain PH_8 PF15409.6 EKE39392.1 - 0.032 14.5 0.1 0.11 12.8 0.1 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain Hydrolase_4 PF12146.8 EKE39393.1 - 1.9e-32 112.4 0.0 2.2e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EKE39393.1 - 8.2e-11 42.0 0.1 6.9e-10 39.0 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKE39393.1 - 2.5e-10 41.3 0.0 2.8e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 EKE39393.1 - 1.1e-05 25.7 0.0 1.8e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Peptidase_S9 PF00326.21 EKE39393.1 - 0.0031 17.0 0.0 3.6 7.0 0.0 2.8 3 0 0 3 3 3 2 Prolyl oligopeptidase family Palm_thioest PF02089.15 EKE39393.1 - 0.011 15.6 0.1 0.051 13.4 0.0 1.8 2 0 0 2 2 2 0 Palmitoyl protein thioesterase PGAP1 PF07819.13 EKE39393.1 - 0.037 13.7 0.1 0.094 12.4 0.0 1.7 2 0 0 2 2 2 0 PGAP1-like protein Acyl_transf_2 PF02273.15 EKE39393.1 - 0.043 13.1 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 Acyl transferase DUF676 PF05057.14 EKE39393.1 - 0.086 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) PfkB PF00294.24 EKE39394.1 - 8.8e-29 100.7 0.0 1.1e-28 100.4 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 EKE39394.1 - 0.03 13.8 0.0 0.048 13.1 0.0 1.4 1 1 0 1 1 1 0 Carbohydrate kinase HAUS-augmin3 PF14932.6 EKE39395.1 - 0.00023 20.8 3.6 0.00025 20.7 3.6 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 DUF16 PF01519.16 EKE39395.1 - 0.00053 20.5 2.8 0.00057 20.3 2.8 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF16 YhdB PF14148.6 EKE39395.1 - 0.0016 18.5 3.0 0.0077 16.3 3.0 2.1 1 1 0 1 1 1 1 YhdB-like protein APG17 PF04108.12 EKE39395.1 - 0.0053 15.9 5.7 0.0061 15.7 5.7 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 FlgN PF05130.12 EKE39395.1 - 0.015 15.8 4.8 0.017 15.6 4.8 1.1 1 0 0 1 1 1 0 FlgN protein EzrA PF06160.12 EKE39395.1 - 0.017 13.3 10.5 0.022 13.0 10.5 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA RecG_N PF17190.4 EKE39395.1 - 0.017 15.8 6.6 0.026 15.2 6.6 1.3 1 0 0 1 1 1 0 RecG N-terminal helical domain UCMA PF17085.5 EKE39395.1 - 0.027 14.5 3.4 0.027 14.5 3.4 2.0 1 1 1 2 2 2 0 Unique cartilage matrix associated protein TMPIT PF07851.13 EKE39395.1 - 0.15 11.3 3.3 0.16 11.2 3.3 1.0 1 0 0 1 1 1 0 TMPIT-like protein FapA PF03961.13 EKE39395.1 - 0.26 9.8 6.6 0.3 9.6 6.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 EKE39395.1 - 0.44 9.8 3.1 0.45 9.8 3.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prefoldin_2 PF01920.20 EKE39395.1 - 0.74 9.8 14.1 2.8 7.9 5.3 2.1 1 1 1 2 2 2 0 Prefoldin subunit PfkB PF00294.24 EKE39396.1 - 3.2e-58 197.4 0.1 3.6e-58 197.2 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Fer4_21 PF14697.6 EKE39398.1 - 2.8e-11 43.4 27.3 4.1e-07 30.0 15.2 1.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 EKE39398.1 - 7.2e-10 39.3 25.8 1.6e-05 25.4 14.7 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4 PF00037.27 EKE39398.1 - 2.1e-09 36.8 16.1 2.4e-07 30.3 4.6 2.3 2 1 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 EKE39398.1 - 1.3e-08 34.9 23.7 1.8e-05 24.8 12.5 1.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EKE39398.1 - 5e-08 32.9 13.2 1e-07 32.0 13.4 1.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EKE39398.1 - 1.1e-07 31.6 14.9 1.8e-06 27.8 4.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EKE39398.1 - 5.1e-06 26.3 15.7 1.5e-05 24.8 3.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 EKE39398.1 - 2.1e-05 25.1 8.8 0.00084 20.0 8.8 2.1 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_16 PF13484.6 EKE39398.1 - 9.8e-05 23.2 12.9 0.026 15.5 3.8 2.2 1 1 2 3 3 3 3 4Fe-4S double cluster binding domain Fer4_8 PF13183.6 EKE39398.1 - 0.0006 20.2 14.3 0.01 16.2 3.5 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 EKE39398.1 - 0.0019 18.7 14.5 0.012 16.1 14.5 2.1 1 1 0 1 1 1 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_17 PF13534.6 EKE39398.1 - 0.0022 18.5 13.1 0.039 14.5 3.4 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 EKE39398.1 - 0.0022 18.8 20.1 0.013 16.4 6.6 2.4 2 1 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.6 EKE39398.1 - 0.0024 18.0 15.0 0.0067 16.6 3.8 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 EKE39398.1 - 0.0036 17.7 15.4 0.012 16.0 3.8 2.5 2 1 0 2 2 2 1 4Fe-4S binding domain Fer4_22 PF17179.4 EKE39398.1 - 0.013 16.3 1.0 0.013 16.3 1.0 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 EKE39398.1 - 0.12 12.6 8.7 2.3 8.4 0.9 2.1 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_19 PF06902.11 EKE39398.1 - 1.2 9.3 9.9 2.2 8.4 9.9 1.5 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster Ras PF00071.22 EKE39399.1 - 1e-52 178.0 0.0 1.2e-52 177.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39399.1 - 2.9e-23 82.4 0.0 5.6e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39399.1 - 3.3e-05 23.4 0.0 9.1e-05 22.0 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family Glyco_hydro_15 PF00723.21 EKE39400.1 - 1.7e-07 30.4 2.3 0.0078 15.0 0.3 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 Pkinase PF00069.25 EKE39402.1 - 7.6e-45 153.3 0.2 1.9e-44 152.0 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39402.1 - 2.7e-19 69.5 0.1 6.3e-19 68.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EKE39402.1 - 0.004 16.8 0.4 0.012 15.2 0.3 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKE39402.1 - 0.06 13.3 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EKE39402.1 - 0.12 11.1 0.1 0.25 10.1 0.1 1.4 1 0 0 1 1 1 0 Fungal protein kinase Beach PF02138.18 EKE39403.1 - 2.6e-12 46.7 0.7 2.7e-06 27.0 0.2 2.5 1 1 0 2 2 2 2 Beige/BEACH domain Laminin_G_3 PF13385.6 EKE39403.1 - 4.8e-06 26.8 0.1 9e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1759 PF03564.15 EKE39403.1 - 0.062 13.2 0.3 3.9 7.4 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1759) PH PF00169.29 EKE39404.1 - 1.7e-09 38.1 0.1 4.9e-09 36.6 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EKE39404.1 - 0.00021 21.7 0.1 0.00064 20.1 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain SMC_hinge PF06470.13 EKE39404.1 - 0.015 15.6 0.0 0.23 11.8 0.0 2.1 2 0 0 2 2 2 0 SMC proteins Flexible Hinge Domain tRNA-synt_2b PF00587.25 EKE39405.1 - 2.5e-35 122.1 0.0 4.7e-35 121.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EKE39405.1 - 3.8e-22 78.2 0.6 9.2e-22 77.0 0.6 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 EKE39405.1 - 1e-08 35.2 0.0 2e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain HGTP_anticodon2 PF12745.7 EKE39405.1 - 0.015 14.8 0.2 0.023 14.2 0.2 1.3 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs TGS PF02824.21 EKE39405.1 - 0.041 13.9 0.0 0.19 11.8 0.0 2.0 2 0 0 2 2 2 0 TGS domain Lipase3_N PF03893.16 EKE39405.1 - 0.13 12.3 0.2 0.45 10.6 0.1 2.0 2 0 0 2 2 2 0 Lipase 3 N-terminal region DUF2072 PF09845.9 EKE39407.1 - 0.067 13.4 1.9 0.079 13.2 0.7 1.7 1 1 1 2 2 2 0 Zn-ribbon containing protein CH PF00307.31 EKE39409.1 - 2e-21 76.2 0.1 2e-21 76.2 0.1 2.9 2 0 0 2 2 2 1 Calponin homology (CH) domain LIM PF00412.22 EKE39409.1 - 6.7e-10 39.0 5.7 1.9e-09 37.6 5.7 1.8 1 0 0 1 1 1 1 LIM domain CAMSAP_CH PF11971.8 EKE39409.1 - 1.1e-06 28.4 0.0 3.1e-06 26.9 0.0 1.9 1 0 0 1 1 1 1 CAMSAP CH domain DZR PF12773.7 EKE39409.1 - 2.1 8.4 6.6 19 5.4 1.8 2.4 1 1 1 2 2 2 0 Double zinc ribbon Lactamase_B_2 PF12706.7 EKE39411.1 - 1.7e-15 57.0 0.0 2.6e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 EKE39411.1 - 1.1e-11 44.2 0.0 2.9e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B PF00753.27 EKE39411.1 - 1.8e-07 31.3 0.6 4.5e-06 26.8 0.5 2.6 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Aha1_N PF09229.11 EKE39412.1 - 8.1e-06 26.1 2.1 8.1e-06 26.1 2.1 1.7 2 1 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal IgG_binding_B PF01378.17 EKE39412.1 - 0.011 15.8 1.7 0.58 10.2 0.3 2.5 2 0 0 2 2 2 0 B domain Top6b_C PF18000.1 EKE39412.1 - 0.035 14.3 0.9 0.052 13.7 0.1 1.7 2 1 0 2 2 2 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain COPIIcoated_ERV PF07970.12 EKE39412.1 - 0.052 13.4 0.0 0.063 13.1 0.0 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum vesicle transporter EF-hand_14 PF17959.1 EKE39412.1 - 0.088 13.2 0.1 0.23 11.8 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain Sec6 PF06046.13 EKE39414.1 - 1.8e-57 195.0 13.1 1.8e-57 195.0 13.1 1.6 2 0 0 2 2 2 1 Exocyst complex component Sec6 Talin_middle PF09141.10 EKE39414.1 - 0.061 13.4 0.2 0.47 10.5 0.1 2.3 1 1 1 2 2 2 0 Talin, middle domain Zip PF02535.22 EKE39415.1 - 2.7 7.1 6.3 4.1 6.5 6.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.12 EKE39415.1 - 9.6 5.5 14.4 18 4.6 14.4 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Peptidase_S41 PF03572.18 EKE39416.1 - 0.013 15.1 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S41 Ribosomal_L7Ae PF01248.26 EKE39417.1 - 4.8e-22 77.5 0.1 5.7e-22 77.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Mob1_phocein PF03637.17 EKE39418.1 - 1.1e-56 191.5 1.7 1.3e-56 191.2 1.7 1.1 1 0 0 1 1 1 1 Mob1/phocein family DUF3717 PF12512.8 EKE39418.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3717) CCDC71L PF15374.6 EKE39419.1 - 0.12 11.6 0.6 0.18 11.0 0.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Cellulase PF00150.18 EKE39419.1 - 0.15 11.5 0.2 0.24 10.8 0.2 1.2 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) LRR_6 PF13516.6 EKE39419.1 - 1.6 9.0 4.9 18 5.7 0.1 4.6 4 0 0 4 4 4 0 Leucine Rich repeat HSP70 PF00012.20 EKE39420.1 - 2.2e-83 280.5 2.8 2.7e-83 280.2 2.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE39420.1 - 1.5e-09 37.1 1.5 1.4e-08 33.9 1.5 2.2 1 1 0 1 1 1 1 MreB/Mbl protein Fibrillarin PF01269.17 EKE39420.1 - 0.0018 17.4 0.1 0.045 12.9 0.0 2.3 2 0 0 2 2 2 1 Fibrillarin StbA PF06406.11 EKE39420.1 - 0.034 13.4 0.1 0.13 11.5 0.0 1.9 2 0 0 2 2 2 0 StbA protein Ras PF00071.22 EKE39422.1 - 1.2e-56 190.8 2.5 1.4e-56 190.5 2.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39422.1 - 5.6e-32 110.5 1.3 5.6e-32 110.5 1.3 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39422.1 - 2.8e-15 56.2 0.5 3.9e-15 55.7 0.5 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE39422.1 - 5e-06 26.2 0.4 2.7e-05 23.8 0.1 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EKE39422.1 - 5.2e-06 26.1 0.4 2.1e-05 24.1 0.4 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EKE39422.1 - 6.9e-06 26.1 0.7 1.4e-05 25.2 0.7 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE39422.1 - 2.3e-05 23.9 0.4 3.8e-05 23.2 0.4 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE39422.1 - 3.8e-05 23.6 0.7 0.32 10.9 0.2 2.6 1 1 2 3 3 3 2 RsgA GTPase Gtr1_RagA PF04670.12 EKE39422.1 - 0.0002 20.8 0.7 0.00027 20.4 0.6 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EKE39422.1 - 0.0015 18.9 0.0 0.0019 18.6 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 EKE39422.1 - 0.0031 17.0 0.1 0.017 14.5 0.0 2.0 2 0 0 2 2 2 1 Bacterial TniB protein PduV-EutP PF10662.9 EKE39422.1 - 0.0066 16.2 0.3 0.088 12.5 0.3 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 EKE39422.1 - 0.0076 15.6 0.3 0.015 14.6 0.1 1.6 2 0 0 2 2 2 1 Septin ATPase_2 PF01637.18 EKE39422.1 - 0.012 15.5 0.6 0.048 13.6 0.6 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EKE39422.1 - 0.05 13.3 2.1 0.73 9.5 2.1 2.5 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EKE39422.1 - 0.059 13.8 0.2 0.96 9.9 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EKE39422.1 - 0.14 12.4 0.2 0.59 10.4 0.0 2.2 2 1 0 2 2 2 0 AAA domain AHSA1 PF08327.11 EKE39423.1 - 2.6e-18 66.4 0.0 2.9e-18 66.3 0.0 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 EKE39423.1 - 0.025 14.8 0.0 0.037 14.3 0.0 1.3 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Radical_SAM PF04055.21 EKE39424.1 - 1.1e-22 81.2 0.2 1.6e-22 80.7 0.2 1.3 1 0 0 1 1 1 1 Radical SAM superfamily DZR PF12773.7 EKE39424.1 - 0.00051 20.0 2.8 0.00051 20.0 2.8 3.2 3 0 0 3 3 3 1 Double zinc ribbon Auto_anti-p27 PF06677.12 EKE39424.1 - 0.012 15.8 5.4 0.59 10.3 1.4 2.9 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) TF_Zn_Ribbon PF08271.12 EKE39424.1 - 0.023 14.2 0.1 0.023 14.2 0.1 2.8 3 0 0 3 3 3 0 TFIIB zinc-binding zf-ribbon_3 PF13248.6 EKE39424.1 - 0.033 13.6 0.4 0.033 13.6 0.4 2.9 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EKE39424.1 - 0.035 13.8 1.0 0.035 13.8 1.0 3.3 3 0 0 3 3 3 0 zinc-ribbon domain ADK_lid PF05191.14 EKE39424.1 - 0.055 13.5 0.2 0.055 13.5 0.2 2.3 3 0 0 3 3 3 0 Adenylate kinase, active site lid SUI1 PF01253.22 EKE39426.1 - 8.7e-13 48.6 5.4 1.6e-12 47.8 5.4 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 Afi1 PF07792.12 EKE39426.1 - 0.018 15.5 3.1 0.024 15.1 3.1 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Zip PF02535.22 EKE39426.1 - 0.036 13.3 0.6 0.046 12.9 0.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DDHD PF02862.17 EKE39426.1 - 0.052 13.7 0.8 0.056 13.6 0.8 1.2 1 0 0 1 1 1 0 DDHD domain TP53IP5 PF15331.6 EKE39426.1 - 0.13 12.4 7.3 0.16 12.1 7.3 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 GNAT_acetyltr_2 PF13718.6 EKE39426.1 - 0.14 11.5 1.9 0.19 11.1 1.9 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Neur_chan_memb PF02932.16 EKE39426.1 - 0.2 11.7 3.9 0.24 11.4 3.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 EKE39426.1 - 0.81 8.4 5.0 0.92 8.2 5.0 1.1 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 EKE39426.1 - 5.3 6.7 6.2 6.8 6.4 6.2 1.1 1 0 0 1 1 1 0 Connexin APG12 PF04110.13 EKE39427.1 - 0.00044 20.6 0.0 0.0005 20.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Rad60-SLD PF11976.8 EKE39427.1 - 0.018 14.8 0.1 0.049 13.5 0.1 1.7 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like UBX PF00789.20 EKE39427.1 - 0.093 12.9 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 UBX domain Vps39_2 PF10367.9 EKE39428.1 - 0.0019 18.6 1.9 0.092 13.2 0.6 3.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 DDE_Tnp_1_3 PF13612.6 EKE39428.1 - 0.0025 17.9 1.2 0.0063 16.5 1.2 1.6 1 0 0 1 1 1 1 Transposase DDE domain zf-RING_UBOX PF13445.6 EKE39428.1 - 0.0088 16.1 3.0 0.023 14.7 3.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_1 PF14446.6 EKE39428.1 - 0.033 14.1 2.6 0.093 12.7 2.6 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-rbx1 PF12678.7 EKE39428.1 - 0.067 13.5 2.2 0.21 11.9 2.2 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EKE39428.1 - 0.1 12.5 4.7 0.32 10.9 4.7 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Frag1 PF10277.9 EKE39428.1 - 0.11 12.0 0.6 0.21 11.1 0.3 1.6 2 0 0 2 2 1 0 Frag1/DRAM/Sfk1 family zf-RING_11 PF17123.5 EKE39428.1 - 0.24 11.2 5.7 0.72 9.7 5.7 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4 PF00097.25 EKE39428.1 - 0.31 10.9 5.8 0.9 9.5 5.8 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EKE39428.1 - 0.43 10.6 8.0 1.1 9.3 8.0 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 EKE39428.1 - 2 8.8 10.6 0.084 13.2 4.4 1.9 2 0 0 2 2 1 0 Ring finger domain PHD PF00628.29 EKE39428.1 - 9 6.3 8.2 1.7 8.6 3.7 2.1 2 0 0 2 2 2 0 PHD-finger RNA_pol_Rpc34 PF05158.12 EKE39429.1 - 3.8e-07 29.8 4.8 4.9e-06 26.1 1.5 2.5 1 1 1 2 2 2 2 RNA polymerase Rpc34 subunit FlxA PF14282.6 EKE39430.1 - 0.022 14.7 6.1 0.25 11.4 1.0 2.4 2 0 0 2 2 2 0 FlxA-like protein HetR_C PF18460.1 EKE39430.1 - 0.11 12.4 0.7 0.81 9.7 0.3 2.3 1 1 1 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain Rap_GAP PF02145.15 EKE39431.1 - 8.6e-40 136.3 0.1 2e-39 135.1 0.1 1.6 1 0 0 1 1 1 1 Rap/ran-GAP Ank_2 PF12796.7 EKE39431.1 - 8.7e-21 74.3 5.7 1.6e-10 41.4 0.2 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EKE39431.1 - 3e-13 49.5 5.6 0.00027 21.3 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EKE39431.1 - 7.7e-13 48.7 1.0 0.00011 22.6 0.1 4.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE39431.1 - 5.8e-12 45.6 5.3 6.7e-06 26.3 0.1 4.7 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE39431.1 - 1.7e-11 43.3 7.2 0.00077 19.7 0.1 5.6 5 0 0 5 5 5 4 Ankyrin repeat Fer2_3 PF13085.6 EKE39432.1 - 0.09 12.8 0.6 0.14 12.2 0.6 1.4 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain TbpB_B_D PF01298.18 EKE39432.1 - 0.16 12.4 2.6 0.25 11.8 1.4 1.7 1 1 1 2 2 2 0 C-lobe and N-lobe beta barrels of Tf-binding protein B UCH PF00443.29 EKE39435.1 - 1.9e-49 168.5 0.0 5.8e-49 166.9 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE39435.1 - 1.4e-12 47.9 6.6 2.6e-07 30.5 0.2 3.3 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase CpXC PF14353.6 EKE39435.1 - 0.1 12.7 0.9 0.42 10.7 0.0 2.4 3 0 0 3 3 3 0 CpXC protein dUTPase PF00692.19 EKE39436.1 - 2.4e-43 146.9 0.1 2.6e-43 146.8 0.1 1.0 1 0 0 1 1 1 1 dUTPase DUF1801 PF08818.11 EKE39438.1 - 0.0086 16.6 0.1 0.015 15.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DU1801) SNase PF00565.17 EKE39439.1 - 1.2e-24 86.8 20.7 5.8e-08 33.2 0.1 5.8 6 0 0 6 6 6 4 Staphylococcal nuclease homologue TUDOR PF00567.24 EKE39439.1 - 7.7e-07 29.2 0.1 7.7e-07 29.2 0.1 2.9 3 0 0 3 3 3 1 Tudor domain MFS_1 PF07690.16 EKE39441.1 - 1.9e-27 96.1 31.9 6.1e-21 74.7 30.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OSR1_C PF12202.8 EKE39441.1 - 0.2 11.9 0.2 0.4 10.9 0.2 1.5 1 0 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain PUF PF00806.19 EKE39443.1 - 6.9e-60 195.5 11.7 3.5e-08 32.7 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF223 PF02721.14 EKE39443.1 - 1.1 9.6 6.0 1 9.7 2.9 2.5 3 1 0 3 3 3 0 Domain of unknown function DUF223 Ras PF00071.22 EKE39444.1 - 3.2e-07 30.1 2.1 1.4e-06 28.0 2.1 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EKE39444.1 - 4e-05 23.8 0.1 0.00013 22.2 0.1 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39444.1 - 0.00026 20.5 0.2 0.00052 19.5 0.2 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE39444.1 - 0.02 15.0 0.5 0.056 13.5 0.1 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase TFIIS_C PF01096.18 EKE39445.1 - 3e-15 55.8 2.2 4.7e-15 55.2 2.2 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) TFIIS_M PF07500.14 EKE39445.1 - 4.7e-11 43.1 1.0 8.2e-11 42.4 1.0 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TF_Zn_Ribbon PF08271.12 EKE39445.1 - 0.025 14.1 2.2 0.14 11.7 1.8 2.3 1 1 1 2 2 2 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.6 EKE39445.1 - 0.16 11.7 0.6 0.16 11.7 0.6 2.9 4 0 0 4 4 4 0 zinc-ribbon domain Hydrolase_4 PF12146.8 EKE39447.1 - 1.9e-06 27.4 0.0 0.014 14.6 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EKE39447.1 - 0.00013 21.5 0.0 0.00029 20.4 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EKE39447.1 - 0.00021 21.3 0.0 0.36 10.7 0.0 2.2 1 1 1 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EKE39447.1 - 0.00097 18.7 0.0 0.0018 17.8 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EKE39447.1 - 0.0036 17.0 0.0 0.019 14.6 0.0 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EKE39447.1 - 0.098 12.5 0.0 1.3 8.8 0.0 2.1 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 EKE39447.1 - 0.23 11.6 0.0 0.35 11.0 0.0 1.2 1 0 0 1 1 1 0 TAP-like protein 7tm_1 PF00001.21 EKE39448.1 - 3.1 7.1 14.5 0.1 11.9 8.6 1.4 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) DELLA PF12041.8 EKE39449.1 - 0.073 13.0 1.1 0.19 11.6 0.2 2.1 2 1 0 2 2 2 0 Transcriptional regulator DELLA protein N terminal Matrilin_ccoil PF10393.9 EKE39449.1 - 0.11 12.4 1.1 0.11 12.4 1.1 1.9 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF4665 PF15679.5 EKE39449.1 - 0.41 11.3 8.4 0.52 11.0 7.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4665) Tox-ODYAM1 PF15642.6 EKE39449.1 - 0.86 8.5 7.5 1.1 8.2 7.5 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus DUF2013 PF09431.10 EKE39450.1 - 0.0013 18.9 4.8 0.0023 18.1 3.7 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF2013) PH PF00169.29 EKE39451.1 - 1.9e-13 50.8 0.5 3.6e-13 49.9 0.5 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EKE39451.1 - 0.0015 18.9 1.3 0.0025 18.2 0.3 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 EKE39451.1 - 0.016 15.3 0.1 0.038 14.1 0.1 1.6 1 0 0 1 1 1 0 PH domain PH_8 PF15409.6 EKE39451.1 - 0.021 15.1 0.0 0.051 13.9 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain DUF4712 PF15830.5 EKE39451.1 - 4.3 6.9 5.8 3.7 7.2 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4712) Ribosomal_L32e PF01655.18 EKE39452.1 - 4e-44 149.4 0.2 4.8e-44 149.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Pkinase PF00069.25 EKE39453.1 - 3e-67 226.8 0.0 3.6e-67 226.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39453.1 - 3.1e-34 118.4 0.0 4e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE39453.1 - 2.1e-05 24.0 0.0 3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EKE39453.1 - 0.015 14.1 0.0 0.023 13.5 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase C12orf66_like PF09404.10 EKE39453.1 - 0.22 10.3 0.6 0.36 9.6 0.6 1.2 1 0 0 1 1 1 0 KICSTOR complex C12orf66 like Exo70 PF03081.15 EKE39454.1 - 3.8e-84 282.9 18.1 4.1e-84 282.8 13.9 2.2 2 0 0 2 2 2 1 Exo70 exocyst complex subunit DUF3896 PF13035.6 EKE39454.1 - 0.029 14.5 0.1 0.14 12.4 0.1 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3896) GAS PF13851.6 EKE39454.1 - 0.91 8.8 9.0 0.27 10.6 2.1 2.9 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.15 EKE39454.1 - 1.6 8.2 4.8 9.8 5.6 0.2 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit KH_8 PF17903.1 EKE39456.1 - 1.5e-31 108.3 1.9 2e-31 107.9 0.0 2.1 2 0 0 2 2 2 1 Krr1 KH1 domain KH_1 PF00013.29 EKE39456.1 - 0.00045 20.0 1.2 0.0013 18.6 1.0 2.0 1 1 0 1 1 1 1 KH domain TCTP PF00838.17 EKE39456.1 - 0.0073 16.7 1.2 0.011 16.0 1.2 1.4 1 0 0 1 1 1 1 Translationally controlled tumour protein DUF1666 PF07891.12 EKE39456.1 - 0.06 13.0 5.6 0.11 12.2 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1666) TPR_1 PF00515.28 EKE39457.1 - 2e-33 112.8 4.8 1.3e-05 24.8 0.0 7.5 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_2 PF07719.17 EKE39457.1 - 3.1e-32 108.0 1.4 0.00021 21.1 0.0 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 EKE39457.1 - 4.4e-22 76.4 5.2 0.019 15.1 0.0 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EKE39457.1 - 1.1e-20 73.6 2.4 3.6e-05 24.0 0.1 4.9 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 EKE39457.1 - 1.5e-17 63.0 8.6 1.5e-05 24.5 0.1 6.5 1 1 6 7 7 7 6 TPR repeat TPR_16 PF13432.6 EKE39457.1 - 4.6e-17 62.4 0.0 8.3e-05 23.2 0.0 3.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EKE39457.1 - 1.6e-16 59.5 0.0 0.038 14.8 0.0 6.7 2 2 5 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EKE39457.1 - 1e-14 53.7 7.2 0.0019 18.5 0.1 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 EKE39457.1 - 1.4e-13 50.8 0.0 0.017 15.2 0.0 5.2 1 1 2 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 EKE39457.1 - 1.5e-12 47.9 0.7 0.0011 19.4 0.0 4.6 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EKE39457.1 - 1.8e-11 43.2 0.9 4.2 7.6 0.0 6.9 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 EKE39457.1 - 6.4e-06 25.6 0.1 0.0075 15.5 0.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EKE39457.1 - 8e-06 26.2 5.8 0.33 11.7 0.0 6.2 7 0 0 7 7 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE39457.1 - 9e-06 25.8 5.0 0.001 19.3 0.2 3.7 1 1 3 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EKE39457.1 - 7.1e-05 22.5 2.1 0.87 9.6 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat BTAD PF03704.17 EKE39457.1 - 0.0016 18.9 0.3 2.4 8.6 0.0 3.4 1 1 3 4 4 4 1 Bacterial transcriptional activator domain TPR_20 PF14561.6 EKE39457.1 - 0.011 16.1 3.2 1.1 9.7 0.0 3.9 3 1 1 5 5 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EKE39457.1 - 0.013 14.9 0.1 0.15 11.4 0.0 2.4 1 1 1 2 2 2 0 MalT-like TPR region DUF3856 PF12968.7 EKE39457.1 - 0.065 13.3 0.4 1.6 8.8 0.0 3.3 2 1 2 4 4 4 0 Domain of Unknown Function (DUF3856) NARP1 PF12569.8 EKE39457.1 - 0.63 8.9 0.0 0.63 8.9 0.0 5.2 1 1 1 5 5 3 0 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 EKE39457.1 - 2 9.3 4.2 3.9 8.4 0.0 3.6 6 0 0 6 6 3 0 Tetratricopeptide repeat PEP-utilizers_C PF02896.18 EKE39458.1 - 1e-110 369.5 0.1 1.5e-110 368.9 0.1 1.3 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.19 EKE39458.1 - 1.1e-54 185.9 0.0 3.4e-42 144.9 0.0 3.3 1 1 0 2 2 2 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.23 EKE39458.1 - 7.8e-25 86.4 0.5 1.8e-24 85.2 0.5 1.6 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain WD40 PF00400.32 EKE39460.1 - 7.3e-32 108.9 9.8 1.9e-08 34.8 0.4 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE39460.1 - 2.5e-12 46.9 3.4 0.0029 17.9 0.1 4.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Utp8 PF10395.9 EKE39460.1 - 2.1e-05 23.3 0.3 3.5e-05 22.5 0.3 1.3 1 0 0 1 1 1 1 Utp8 family BBS2_Mid PF14783.6 EKE39460.1 - 0.00015 21.8 1.5 0.19 11.8 0.1 2.8 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Lactonase PF10282.9 EKE39460.1 - 0.0013 18.1 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller DUF5046 PF16465.5 EKE39460.1 - 0.1 12.1 0.1 0.48 9.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5046) Ribosomal_L37e PF01907.19 EKE39461.1 - 2.4e-25 88.4 12.3 3.9e-25 87.8 12.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 EKE39461.1 - 0.0042 17.1 3.7 0.0055 16.7 3.7 1.2 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 EKE39461.1 - 0.049 13.6 2.4 0.059 13.4 2.4 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF4543 PF15076.6 EKE39461.1 - 0.056 13.6 0.1 0.067 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4543) DUF2688 PF10892.8 EKE39461.1 - 0.1 12.1 2.6 9.7 5.7 1.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) zinc_ribbon_6 PF14599.6 EKE39461.1 - 0.23 11.5 4.4 0.37 10.8 4.4 1.3 1 0 0 1 1 1 0 Zinc-ribbon zf-C3HC4_2 PF13923.6 EKE39461.1 - 0.44 10.4 4.6 0.71 9.8 4.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TLD PF07534.16 EKE39462.1 - 8.1e-06 26.1 1.1 8.1e-06 26.1 1.1 2.7 3 1 0 3 3 3 1 TLD GUCT PF08152.12 EKE39462.1 - 0.026 14.8 2.0 0.13 12.6 0.0 3.0 3 1 1 4 4 4 0 GUCT (NUC152) domain Pkinase PF00069.25 EKE39463.1 - 1.1e-62 211.8 0.0 1.3e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39463.1 - 2.2e-46 158.2 0.0 2.9e-46 157.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE39463.1 - 1.2e-07 30.9 0.4 2e-07 30.1 0.4 1.3 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EKE39463.1 - 0.017 14.7 0.7 0.037 13.6 0.3 1.8 1 1 0 2 2 2 0 RIO1 family Kdo PF06293.14 EKE39463.1 - 0.036 13.4 0.2 0.092 12.1 0.3 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EKE39463.1 - 0.069 12.4 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF4746 PF15928.5 EKE39463.1 - 0.074 12.5 4.1 0.11 11.9 4.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Haspin_kinase PF12330.8 EKE39463.1 - 0.26 10.2 0.4 1.7 7.5 0.4 1.9 1 1 0 1 1 1 0 Haspin like kinase domain BUD22 PF09073.10 EKE39463.1 - 0.45 9.8 11.9 0.64 9.3 11.9 1.2 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 EKE39463.1 - 0.56 9.5 23.8 0.93 8.8 23.8 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 EKE39463.1 - 0.72 8.1 14.6 1.1 7.5 14.6 1.2 1 0 0 1 1 1 0 CDC45-like protein SGT1 PF07093.11 EKE39463.1 - 1.4 7.2 7.8 2 6.8 7.8 1.1 1 0 0 1 1 1 0 SGT1 protein RNA_pol_3_Rpc31 PF11705.8 EKE39463.1 - 2.1 8.5 28.0 3.3 7.9 28.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Vfa1 PF08432.10 EKE39463.1 - 2.2 8.6 6.8 3.4 8.0 6.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Nop14 PF04147.12 EKE39463.1 - 2.3 6.3 22.3 3.2 5.9 22.3 1.1 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.13 EKE39463.1 - 2.8 7.8 18.0 4.5 7.1 18.0 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Cwf_Cwc_15 PF04889.12 EKE39463.1 - 3 7.5 20.2 5.4 6.7 20.2 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SspB PF04386.13 EKE39463.1 - 5.4 6.9 8.0 9.4 6.1 8.0 1.3 1 0 0 1 1 1 0 Stringent starvation protein B DUF2457 PF10446.9 EKE39463.1 - 5.4 6.0 30.7 7.8 5.5 30.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 EKE39463.1 - 9.1 4.2 31.4 12 3.8 31.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi ubiquitin PF00240.23 EKE39464.1 - 5.4e-33 112.6 0.4 6e-33 112.4 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKE39464.1 - 2.1e-17 62.7 0.4 2.3e-17 62.6 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EKE39464.1 - 2.5e-05 24.6 0.1 0.00011 22.6 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EKE39464.1 - 0.00046 20.5 0.1 0.00052 20.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EKE39464.1 - 0.0034 17.3 0.0 0.0037 17.2 0.0 1.2 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EKE39464.1 - 0.0034 17.5 0.1 0.0075 16.4 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EKE39464.1 - 0.0071 16.4 0.6 3.4 7.8 0.0 2.0 1 1 1 2 2 2 2 Ubiquitin-like domain DUF2870 PF11069.8 EKE39464.1 - 0.11 12.9 0.2 0.64 10.4 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2870) VHS PF00790.19 EKE39465.1 - 1.4e-07 31.4 0.9 1.4e-07 31.4 0.9 2.4 2 1 0 3 3 3 1 VHS domain DUF3496 PF12001.8 EKE39465.1 - 0.035 14.5 3.1 1.2 9.6 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) PSD2 PF07624.11 EKE39465.1 - 0.068 13.0 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1585) GAT PF03127.14 EKE39465.1 - 0.34 11.2 4.9 0.18 12.2 2.2 2.0 2 0 0 2 2 2 0 GAT domain DUF4355 PF14265.6 EKE39465.1 - 0.64 10.3 7.4 0.078 13.2 1.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Pkinase PF00069.25 EKE39466.1 - 1.9e-50 171.7 1.4 2.7e-50 171.2 1.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39466.1 - 1.9e-21 76.5 0.1 2.6e-21 76.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DivIC PF04977.15 EKE39466.1 - 0.05 13.4 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Septum formation initiator SelK_SelG PF10961.8 EKE39468.1 - 0.31 11.7 0.8 0.41 11.3 0.8 1.2 1 0 0 1 1 1 0 Selenoprotein SelK_SelG zf-C3HC4_3 PF13920.6 EKE39469.1 - 0.00054 19.8 15.2 0.0011 18.8 15.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Siva PF05458.12 EKE39469.1 - 0.036 13.8 10.5 0.075 12.7 10.5 1.5 1 0 0 1 1 1 0 Cd27 binding protein (Siva) zf-RING_5 PF14634.6 EKE39469.1 - 0.046 13.7 15.4 0.11 12.5 15.4 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EKE39469.1 - 0.22 11.4 16.3 0.53 10.2 16.3 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE39469.1 - 0.35 11.2 13.8 0.83 10.0 13.8 1.7 1 0 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.6 EKE39469.1 - 0.74 9.7 13.2 1.4 8.8 13.2 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EKE39469.1 - 1.7 8.7 8.2 5.1 7.2 8.2 1.8 1 1 0 1 1 1 0 RING-type zinc-finger DUF4618 PF15397.6 EKE39470.1 - 0.042 13.3 14.0 0.052 13.0 14.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Seadorna_VP6 PF07407.11 EKE39470.1 - 0.045 12.7 0.5 0.05 12.6 0.5 1.2 1 0 0 1 1 1 0 Seadornavirus VP6 protein Aminotran_1_2 PF00155.21 EKE39470.1 - 0.07 12.3 0.1 0.086 12.0 0.1 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II CtIP_N PF10482.9 EKE39470.1 - 0.1 12.7 15.7 0.94 9.5 15.7 2.0 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Phlebovirus_NSM PF07246.11 EKE39470.1 - 0.39 10.0 12.7 0.26 10.6 1.5 2.0 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M TMPIT PF07851.13 EKE39470.1 - 0.51 9.5 5.4 0.64 9.2 5.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein SlyX PF04102.12 EKE39470.1 - 0.67 10.6 11.6 1.4 9.6 6.7 2.4 2 0 0 2 2 2 0 SlyX Atg14 PF10186.9 EKE39470.1 - 1.8 7.6 11.4 2.7 7.0 11.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIC PF04977.15 EKE39470.1 - 1.9 8.3 20.1 2.4 8.0 2.3 3.3 1 1 2 3 3 3 0 Septum formation initiator Exonuc_VII_L PF02601.15 EKE39470.1 - 2 7.9 7.6 2.7 7.5 7.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit L27_2 PF09045.10 EKE39470.1 - 3.2 7.8 7.0 2.7 8.0 0.8 2.9 3 0 0 3 3 3 0 L27_2 bZIP_2 PF07716.15 EKE39470.1 - 3.7 7.7 16.6 0.36 11.0 1.6 2.3 2 0 0 2 2 2 0 Basic region leucine zipper HALZ PF02183.18 EKE39470.1 - 4 7.7 12.6 1.2 9.4 1.7 3.1 2 1 1 3 3 3 0 Homeobox associated leucine zipper DUF5320 PF17253.2 EKE39470.1 - 4.5 8.4 4.8 5.1 8.2 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DUF4407 PF14362.6 EKE39470.1 - 7.3 5.8 10.9 19 4.5 10.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Uso1_p115_C PF04871.13 EKE39470.1 - 8 6.9 16.3 0.75 10.2 3.4 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Cas_Cas1 PF01867.16 EKE39471.1 - 0.0051 16.0 0.3 0.0058 15.8 0.3 1.0 1 0 0 1 1 1 1 CRISPR associated protein Cas1 Prefoldin_2 PF01920.20 EKE39471.1 - 0.035 14.1 9.3 0.99 9.4 0.6 2.1 2 0 0 2 2 2 0 Prefoldin subunit zf-C4H2 PF10146.9 EKE39471.1 - 0.75 10.1 4.6 0.83 9.9 4.6 1.0 1 0 0 1 1 1 0 Zinc finger-containing protein Nodulin-like PF06813.13 EKE39472.1 - 0.044 13.3 8.2 0.014 14.8 4.4 1.8 1 1 1 2 2 2 0 Nodulin-like DUF3278 PF11683.8 EKE39472.1 - 0.05 13.7 8.6 0.033 14.3 7.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3278) PIRT PF15099.6 EKE39472.1 - 3.1 7.4 7.3 4.9 6.7 2.8 2.1 1 1 1 2 2 2 0 Phosphoinositide-interacting protein family DUF2258 PF10015.9 EKE39473.1 - 0.0017 18.4 4.7 5.5 7.2 0.3 3.3 3 0 0 3 3 3 2 Uncharacterized protein conserved in archaea (DUF2258) DUF4962 PF16332.5 EKE39473.1 - 0.029 12.9 1.5 0.043 12.3 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4962) DUF1192 PF06698.11 EKE39473.1 - 0.05 13.7 0.8 0.15 12.2 0.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) Rho_N PF07498.12 EKE39473.1 - 0.07 13.1 9.0 5.7 6.9 0.1 4.4 3 1 1 4 4 4 0 Rho termination factor, N-terminal domain BTHB PF18410.1 EKE39473.1 - 0.075 12.9 3.5 1.8 8.4 0.3 3.1 3 1 0 3 3 3 0 Basic tilted helix bundle domain Tegument_dsDNA PF12818.7 EKE39473.1 - 0.16 11.1 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 dsDNA viral tegument protein GDPD PF03009.17 EKE39475.1 - 2.2e-22 80.1 0.0 7.1e-22 78.4 0.0 1.8 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ninjurin PF04923.12 EKE39476.1 - 0.38 10.7 8.8 0.11 12.5 4.5 2.0 1 1 1 2 2 2 0 Ninjurin DHHC PF01529.20 EKE39476.1 - 6.2 6.9 14.5 31 4.7 12.6 2.2 1 1 1 2 2 2 0 DHHC palmitoyltransferase NopRA1 PF16201.5 EKE39477.1 - 0.00051 19.7 1.1 0.14 11.7 0.1 3.7 2 2 1 3 3 3 2 Nucleolar pre-ribosomal-associated protein 1 bact-PGI_C PF10432.9 EKE39477.1 - 0.02 15.0 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial phospho-glucose isomerase C-terminal SIS domain DUF3361 PF11841.8 EKE39477.1 - 0.088 12.7 6.9 0.22 11.5 0.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF3361) IBB PF01749.20 EKE39477.1 - 0.49 10.9 9.5 1.2 9.7 9.5 1.6 1 0 0 1 1 1 0 Importin beta binding domain RhoGEF PF00621.20 EKE39478.1 - 6.8e-38 130.7 8.2 6.8e-38 130.7 8.2 2.9 3 1 0 3 3 3 1 RhoGEF domain FYVE PF01363.21 EKE39478.1 - 2.7e-17 62.7 9.3 7.4e-17 61.2 9.3 1.8 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EKE39478.1 - 2.9e-08 34.1 1.1 2.9e-08 34.1 1.1 2.3 2 0 0 2 2 2 1 PH domain PH_16 PF17838.1 EKE39478.1 - 0.0011 18.8 6.9 0.0067 16.3 2.2 3.1 2 1 0 2 2 2 1 PH domain PH_13 PF16652.5 EKE39478.1 - 0.025 14.4 13.9 0.029 14.2 3.3 3.9 2 1 1 3 3 3 0 Pleckstrin homology domain 3-dmu-9_3-mt PF06983.13 EKE39478.1 - 0.87 10.1 5.4 4.2 7.9 0.1 3.5 3 1 0 3 3 3 0 3-demethylubiquinone-9 3-methyltransferase SpoVT_C PF15714.5 EKE39478.1 - 1.8 8.6 7.5 1.2 9.1 0.3 3.2 3 0 0 3 3 3 0 Stage V sporulation protein T C-terminal, transcription factor UEV PF05743.13 EKE39479.1 - 1.4e-17 63.7 0.5 3.5e-17 62.4 0.5 1.7 1 0 0 1 1 1 1 UEV domain Nif11 PF07862.11 EKE39479.1 - 0.17 12.2 0.1 0.17 12.2 0.1 1.6 2 0 0 2 2 2 0 Nif11 domain Maelstrom PF13017.6 EKE39480.1 - 9.6e-47 159.4 7.9 1.2e-46 159.1 7.9 1.0 1 0 0 1 1 1 1 piRNA pathway germ-plasm component UNC80 PF15778.5 EKE39480.1 - 0.0059 16.2 0.2 0.022 14.4 0.0 2.0 2 0 0 2 2 2 1 Cation channel complex component UNC80 SIP1 PF04938.12 EKE39481.1 - 1.5e-14 54.3 0.0 1.6e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) HicA_toxin PF07927.12 EKE39482.1 - 0.13 12.3 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, LRR_5 PF13306.6 EKE39483.1 - 6.7e-44 149.0 22.2 5.4e-27 94.3 10.1 3.6 2 2 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE39483.1 - 3.6e-14 52.2 0.1 3.5e-06 26.7 0.1 4.7 2 2 3 5 5 5 3 Leucine rich repeat TPR_1 PF00515.28 EKE39485.1 - 1.1e-10 40.8 9.6 7.8e-06 25.5 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EKE39485.1 - 1.8e-09 37.0 6.9 0.00011 22.0 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKE39485.1 - 7.2e-09 35.2 2.7 1.3e-08 34.4 0.3 2.7 2 1 1 3 3 3 1 TPR repeat TPR_12 PF13424.6 EKE39485.1 - 2.9e-07 30.7 5.8 1.6e-05 25.1 1.1 3.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EKE39485.1 - 3.3e-06 26.7 2.2 0.15 12.2 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKE39485.1 - 1.4e-05 24.9 6.9 0.0097 16.1 0.0 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EKE39485.1 - 9.5e-05 22.5 0.8 0.0033 17.7 0.2 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EKE39485.1 - 0.028 15.2 0.4 54 5.0 0.0 3.7 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EKE39485.1 - 0.028 14.9 1.8 1.2 9.7 0.1 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EKE39485.1 - 0.1 12.5 3.4 4 7.4 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 EKE39485.1 - 0.17 12.0 0.0 29 4.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat NT-C2 PF10358.9 EKE39486.1 - 4.5e-18 65.4 1.6 8.8e-18 64.4 1.6 1.5 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 EKE39486.1 - 1.8e-09 37.8 1.7 5.7e-09 36.2 0.3 2.4 3 0 0 3 3 3 1 DIL domain Phage_Cox PF10743.9 EKE39486.1 - 0.022 14.8 0.0 0.066 13.3 0.0 1.8 1 0 0 1 1 1 0 Regulatory phage protein cox PseudoU_synth_1 PF01416.20 EKE39487.1 - 9.6e-11 42.1 0.0 1.4e-09 38.4 0.0 2.3 2 0 0 2 2 2 1 tRNA pseudouridine synthase Phage_SSB PF16773.5 EKE39487.1 - 0.01 15.9 2.8 0.024 14.7 0.1 2.5 2 1 0 2 2 2 0 Lactococcus phage single-stranded DNA binding protein VSP PF03302.13 EKE39488.1 - 0.00014 20.9 46.7 0.0016 17.3 25.0 2.1 1 1 1 2 2 2 2 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EKE39488.1 - 0.14 12.4 45.8 2.1 8.6 7.6 3.5 1 1 2 3 3 3 0 Furin-like repeat, cysteine-rich Metallophos PF00149.28 EKE39489.1 - 2e-08 35.0 1.7 4.1e-08 34.0 1.7 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE39489.1 - 8.1e-05 22.9 0.5 0.00021 21.6 0.5 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EKE39489.1 - 0.0022 17.3 0.0 0.01 15.2 0.0 2.0 2 0 0 2 2 2 1 Metallophosphoesterase, calcineurin superfamily Collar PF07484.12 EKE39489.1 - 0.079 13.0 0.0 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 Phage Tail Collar Domain DIX PF00778.17 EKE39489.1 - 0.17 11.7 1.7 0.44 10.4 0.5 2.3 3 0 0 3 3 3 0 DIX domain zf-H2C2 PF09337.10 EKE39490.1 - 0.13 12.5 0.1 0.27 11.5 0.1 1.5 1 0 0 1 1 1 0 H2C2 zinc finger Rtt106 PF08512.12 EKE39490.1 - 0.43 11.0 2.9 1.7 9.1 0.3 2.8 2 1 1 3 3 3 0 Histone chaperone Rttp106-like TLD PF07534.16 EKE39491.1 - 1.9 8.7 7.5 0.62 10.3 0.2 3.2 2 2 1 4 4 4 0 TLD DUF1796 PF08795.10 EKE39491.1 - 2 8.3 7.2 0.53 10.2 1.8 2.4 2 1 1 3 3 3 0 Putative papain-like cysteine peptidase (DUF1796) Pribosyltran_N PF13793.6 EKE39492.1 - 3.6e-19 68.8 0.1 8.3e-17 61.2 0.0 2.8 2 1 1 3 3 3 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EKE39492.1 - 1.2e-12 48.3 2.9 1.2e-12 48.3 2.9 1.5 2 0 0 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EKE39492.1 - 7.5e-10 38.5 0.4 3e-09 36.6 0.2 1.9 2 0 0 2 2 2 1 Phosphoribosyl transferase domain HydF_dimer PF18128.1 EKE39492.1 - 0.13 12.3 1.1 0.25 11.4 0.4 1.8 2 0 0 2 2 2 0 Hydrogen maturase F dimerization domain TGT PF01702.18 EKE39493.1 - 4.9e-131 437.0 0.0 6.4e-131 436.7 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF1977 PF09320.11 EKE39494.1 - 0.067 13.5 1.0 0.096 12.9 1.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1977) Dermcidin PF15291.6 EKE39494.1 - 0.091 13.3 0.0 0.13 12.8 0.0 1.3 1 1 0 1 1 1 0 Dermcidin, antibiotic peptide CCDC-167 PF15188.6 EKE39494.1 - 0.11 12.9 4.0 0.21 12.0 4.0 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 CN_hydrolase PF00795.22 EKE39495.1 - 1.5e-33 116.2 0.0 1.9e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase PI3_PI4_kinase PF00454.27 EKE39496.1 - 0.00014 21.8 3.4 0.0005 20.0 0.2 2.8 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase QueF_N PF14819.6 EKE39496.1 - 0.5 10.7 5.1 0.23 11.8 0.2 2.8 3 0 0 3 3 3 0 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term Exo_endo_phos PF03372.23 EKE39497.1 - 5.9e-18 65.2 0.0 8.7e-18 64.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EKE39497.1 - 0.021 14.7 0.1 0.095 12.5 0.1 2.1 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase SWI2_SNF2 PF18766.1 EKE39498.1 - 2.7e-26 92.6 0.5 8.5e-26 91.0 0.1 2.0 2 0 0 2 2 2 1 SWI2/SNF2 ATPase ResIII PF04851.15 EKE39498.1 - 7.7e-18 65.1 0.6 3e-17 63.2 0.6 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EKE39498.1 - 5.2e-10 39.4 0.3 1.4e-09 37.9 0.3 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase MAP PF03642.13 EKE39498.1 - 0.022 15.0 0.1 0.083 13.2 0.1 1.9 1 0 0 1 1 1 0 MAP domain Ribosomal_S19 PF00203.21 EKE39499.1 - 5.2e-34 116.0 0.7 9.8e-34 115.1 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S19 Ubiquitin_2 PF14560.6 EKE39500.1 - 0.04 14.4 0.2 0.089 13.3 0.2 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain PI3_PI4_kinase PF00454.27 EKE39501.1 - 2.7e-07 30.7 0.4 1.6e-06 28.1 0.3 2.3 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase MCR PF18509.1 EKE39501.1 - 0.092 12.3 0.4 0.17 11.5 0.4 1.4 1 0 0 1 1 1 0 Magnetochrome domain UBA_4 PF14555.6 EKE39501.1 - 0.1 12.4 0.0 0.3 10.9 0.0 1.8 2 0 0 2 2 2 0 UBA-like domain Peptidase_M20 PF01546.28 EKE39502.1 - 2e-31 109.3 0.0 2.6e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EKE39502.1 - 1.1e-17 63.9 0.0 2e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EKE39502.1 - 6.2e-08 32.6 0.0 3e-07 30.3 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M28 ERF PF04404.12 EKE39502.1 - 0.036 13.9 0.5 0.065 13.1 0.5 1.4 1 0 0 1 1 1 0 ERF superfamily DUF2028 PF09667.10 EKE39503.1 - 4 7.4 6.2 2.6 7.9 0.4 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF2028) SH3_1 PF00018.28 EKE39504.1 - 4e-13 48.8 1.2 6.5e-13 48.1 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EKE39504.1 - 2.8e-11 42.9 0.2 5.2e-11 42.0 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EKE39504.1 - 1.5e-09 37.6 0.0 3e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR PF03114.18 EKE39504.1 - 4.5e-07 29.7 14.9 4.5e-07 29.7 14.9 2.4 2 1 0 2 2 2 1 BAR domain BRICHOS PF04089.14 EKE39504.1 - 0.045 14.0 0.4 0.045 14.0 0.4 2.7 3 2 0 3 3 3 0 BRICHOS domain PhoU PF01895.19 EKE39504.1 - 0.2 12.1 11.5 2.2 8.8 0.3 3.5 3 1 0 3 3 3 0 PhoU domain Fungal_trans_2 PF11951.8 EKE39504.1 - 0.44 9.3 2.1 1.1 7.9 0.1 2.1 2 1 0 2 2 2 0 Fungal specific transcription factor domain zf-C3HC4_3 PF13920.6 EKE39505.1 - 2.2e-13 49.9 7.0 3.1e-13 49.4 7.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE39505.1 - 3.8e-12 45.8 9.1 5.4e-12 45.4 9.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE39505.1 - 8.5e-12 45.2 9.8 1.2e-11 44.7 9.8 1.2 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EKE39505.1 - 2.9e-10 39.8 6.4 4.4e-10 39.3 6.4 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EKE39505.1 - 1.5e-09 37.6 8.4 2.3e-09 37.0 8.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE39505.1 - 6.3e-09 35.7 1.7 6.3e-09 35.7 1.7 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EKE39505.1 - 8e-09 35.3 7.6 1.5e-08 34.5 7.5 1.5 1 1 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EKE39505.1 - 1.8e-07 31.3 8.1 2.9e-07 30.7 8.1 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EKE39505.1 - 8.7e-06 25.8 6.8 1.6e-05 24.9 6.1 1.8 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 EKE39505.1 - 0.00013 21.5 3.5 0.00016 21.2 3.5 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-ANAPC11 PF12861.7 EKE39505.1 - 0.004 17.2 3.2 0.0061 16.6 3.2 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EKE39505.1 - 0.012 15.4 4.0 0.012 15.4 4.0 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_4 PF14570.6 EKE39505.1 - 0.013 15.2 7.7 0.029 14.2 7.6 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_14 PF17978.1 EKE39505.1 - 0.016 15.7 3.1 0.026 15.0 2.7 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 EKE39505.1 - 0.023 14.3 6.4 0.042 13.5 6.4 1.4 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_6 PF14835.6 EKE39505.1 - 0.035 14.0 2.9 0.11 12.4 2.9 1.7 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 EKE39505.1 - 0.099 12.8 4.9 0.17 12.0 4.9 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 Zn_ribbon_17 PF17120.5 EKE39505.1 - 0.1 12.2 7.5 0.16 11.6 7.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type TerY_C PF15616.6 EKE39505.1 - 0.14 12.3 3.5 0.2 11.8 3.5 1.2 1 0 0 1 1 1 0 TerY-C metal binding domain Baculo_IE-1 PF05290.11 EKE39505.1 - 0.19 11.7 4.4 0.35 10.8 4.4 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) IBR PF01485.21 EKE39505.1 - 0.21 11.9 9.5 0.19 12.0 7.3 2.0 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain DUF1272 PF06906.11 EKE39505.1 - 1.7 8.8 6.9 11 6.3 6.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1272) RecR PF02132.15 EKE39505.1 - 3.6 7.2 6.3 5.1 6.7 2.0 2.3 2 0 0 2 2 2 0 RecR protein FANCL_C PF11793.8 EKE39505.1 - 3.7 7.8 13.1 2.4e+02 2.0 13.1 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain C2 PF00168.30 EKE39506.1 - 3.9e-31 107.4 0.3 9.6e-15 54.7 0.1 2.6 3 0 0 3 3 3 2 C2 domain ThiF PF00899.21 EKE39507.1 - 8e-64 215.3 0.1 1.1e-63 214.8 0.1 1.1 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 EKE39507.1 - 5.6e-09 36.3 0.5 1e-06 28.9 0.0 2.4 1 1 0 2 2 2 1 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 EKE39507.1 - 4.1e-05 24.1 0.9 0.0001 22.8 0.9 1.7 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain NAD_binding_7 PF13241.6 EKE39507.1 - 0.00015 22.1 0.1 0.00075 19.9 0.1 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding DUF1128 PF06569.11 EKE39507.1 - 0.041 13.9 0.1 0.13 12.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) Shikimate_DH PF01488.20 EKE39507.1 - 0.049 13.7 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase C1_2 PF03107.16 EKE39507.1 - 0.096 13.0 1.9 0.11 12.9 0.2 2.0 2 0 0 2 2 2 0 C1 domain Sacchrp_dh_NADP PF03435.18 EKE39507.1 - 0.25 11.6 3.1 1.4 9.2 3.1 2.1 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AAA_12 PF13087.6 EKE39508.1 - 1.7e-54 184.5 0.2 6.2e-54 182.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EKE39508.1 - 4.4e-41 141.4 7.1 1.5e-20 74.1 0.6 3.0 2 1 1 3 3 3 2 AAA domain UPF1_Zn_bind PF09416.10 EKE39508.1 - 5.2e-36 123.9 10.5 5.2e-36 123.9 10.5 3.2 4 0 0 4 4 4 1 RNA helicase (UPF2 interacting domain) AAA_30 PF13604.6 EKE39508.1 - 1.9e-12 47.3 0.0 1.1e-11 44.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKE39508.1 - 6.5e-11 42.8 0.3 5.4e-10 39.8 0.0 2.6 3 1 0 3 3 2 1 AAA domain ResIII PF04851.15 EKE39508.1 - 1.5e-07 31.6 0.0 5.1e-07 29.8 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EKE39508.1 - 0.00042 19.7 0.0 0.0049 16.2 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.22 EKE39508.1 - 0.0041 16.8 0.0 0.0082 15.8 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain PhoH PF02562.16 EKE39508.1 - 0.0048 16.4 0.0 0.0094 15.4 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein DEAD PF00270.29 EKE39508.1 - 0.0072 16.1 3.0 0.15 11.8 3.0 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_RecD PF05127.14 EKE39508.1 - 0.0089 15.9 0.0 0.022 14.6 0.0 1.7 1 0 0 1 1 1 1 Helicase AAA_22 PF13401.6 EKE39508.1 - 0.14 12.4 0.0 0.4 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.7 EKE39508.1 - 0.23 10.4 3.2 0.096 11.6 0.2 1.8 2 0 0 2 2 2 0 AAA-like domain DDE_1 PF03184.19 EKE39509.1 - 0.0026 17.4 4.0 0.038 13.7 0.0 3.1 3 0 0 3 3 3 1 DDE superfamily endonuclease Phage_int_SAM_4 PF13495.6 EKE39509.1 - 0.024 15.1 2.5 0.48 10.9 0.1 3.5 3 0 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain Phg_2220_C PF09524.10 EKE39509.1 - 0.031 14.3 0.4 0.031 14.3 0.4 2.4 2 0 0 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) DUF1851 PF08906.11 EKE39509.1 - 0.13 12.3 3.1 16 5.6 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1851) Pkinase PF00069.25 EKE39510.1 - 9.6e-50 169.4 1.4 1.4e-49 168.9 0.5 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39510.1 - 1.4e-43 149.1 0.2 2.2e-43 148.4 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sel1 PF08238.12 EKE39510.1 - 3.5e-39 132.4 21.0 1.2e-07 32.2 0.1 9.5 9 0 0 9 9 9 6 Sel1 repeat Pkinase_fungal PF17667.1 EKE39510.1 - 2.5e-08 33.1 0.1 4.7e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase ANAPC3 PF12895.7 EKE39510.1 - 0.00092 19.4 9.8 0.014 15.6 0.6 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Kdo PF06293.14 EKE39510.1 - 0.027 13.9 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_12 PF13424.6 EKE39510.1 - 0.24 11.7 4.4 21 5.5 0.1 5.2 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 EKE39510.1 - 0.29 11.7 3.7 6.9 7.3 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EKE39510.1 - 0.52 10.6 28.5 0.09 12.9 0.6 7.4 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_7 PF13176.6 EKE39510.1 - 0.65 10.2 7.1 15 5.9 0.2 5.2 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EKE39510.1 - 3.1 8.2 24.0 6 7.3 0.1 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat DER1 PF04511.15 EKE39511.1 - 7.1e-24 84.8 18.8 8.8e-24 84.5 18.8 1.1 1 0 0 1 1 1 1 Der1-like family Skp1_POZ PF03931.15 EKE39513.1 - 2.5e-11 43.6 0.9 3.8e-11 43.0 0.9 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Skp1 PF01466.19 EKE39513.1 - 9.4e-11 41.7 0.2 1.5e-10 41.0 0.2 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain RasGAP PF00616.19 EKE39514.1 - 2.2e-18 66.8 5.0 1.2e-12 48.0 0.6 4.2 3 2 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase TLD PF07534.16 EKE39515.1 - 2.1e-08 34.5 1.0 4.4e-08 33.4 1.0 1.6 1 0 0 1 1 1 1 TLD Toprim PF01751.22 EKE39515.1 - 0.1 12.8 0.6 0.4 10.9 0.4 2.0 1 1 1 2 2 2 0 Toprim domain Ada3 PF10198.9 EKE39516.1 - 0.14 12.3 0.1 0.27 11.4 0.1 1.5 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 TPR_2 PF07719.17 EKE39517.1 - 2.8e-11 42.6 9.6 0.00085 19.3 0.5 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EKE39517.1 - 2.2e-08 33.6 12.3 1.2e-05 24.8 0.6 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EKE39517.1 - 0.00078 20.0 0.0 0.0042 17.7 0.0 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat RPAP3_C PF13877.6 EKE39517.1 - 0.0027 18.2 0.8 0.0049 17.4 0.2 1.8 2 0 0 2 2 2 1 Potential Monad-binding region of RPAP3 TPR_21 PF09976.9 EKE39517.1 - 0.0032 17.2 0.1 0.0063 16.2 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain TPR_8 PF13181.6 EKE39517.1 - 0.0032 17.5 11.5 0.65 10.4 0.5 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EKE39517.1 - 0.01 15.9 7.7 0.098 12.7 0.3 3.4 1 1 2 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 EKE39517.1 - 0.023 15.0 3.9 3 8.4 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat B PF02216.16 EKE39517.1 - 0.037 14.0 4.1 3.2 7.8 0.3 3.5 3 0 0 3 3 3 0 B domain TPR_12 PF13424.6 EKE39517.1 - 0.042 14.1 2.8 9.3 6.6 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EKE39517.1 - 0.076 12.7 3.3 0.15 11.7 0.5 2.4 2 0 0 2 2 2 0 TPR repeat TPR_19 PF14559.6 EKE39517.1 - 0.28 11.7 2.4 0.71 10.4 1.2 2.3 2 1 0 2 2 2 0 Tetratricopeptide repeat Ras PF00071.22 EKE39518.1 - 3e-19 69.2 0.0 3.4e-19 69.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39518.1 - 7.1e-10 39.1 0.0 9.7e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EKE39518.1 - 3.4e-05 23.4 0.0 3.8e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE39518.1 - 4.2e-05 23.2 0.4 0.0065 16.0 0.4 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Septin PF00735.18 EKE39518.1 - 0.0093 15.3 0.3 0.014 14.7 0.2 1.7 1 1 1 2 2 2 1 Septin AAA_22 PF13401.6 EKE39518.1 - 0.012 15.8 0.0 0.024 14.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EKE39518.1 - 0.1 13.0 0.2 15 6.0 0.1 2.2 2 0 0 2 2 2 0 RNA helicase Lin-8 PF03353.15 EKE39519.1 - 0.45 10.0 36.4 0.62 9.6 36.4 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist RRM_1 PF00076.22 EKE39520.1 - 1.9e-39 133.3 3.1 1.1e-19 70.0 0.6 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EKE39520.1 - 0.00011 22.2 0.7 0.017 15.3 0.1 3.1 2 2 0 2 2 2 1 RNA recognition motif Limkain-b1 PF11608.8 EKE39520.1 - 0.0014 18.7 0.3 1.6 8.9 0.1 2.9 2 1 0 2 2 2 2 Limkain b1 Nup35_RRM_2 PF14605.6 EKE39520.1 - 0.0069 16.4 0.1 0.017 15.1 0.1 1.7 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 EKE39520.1 - 0.02 14.6 0.4 7 6.4 0.0 2.7 2 0 0 2 2 2 0 Ribonuclease B OB domain RRM_occluded PF16842.5 EKE39520.1 - 0.044 13.6 0.0 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 Occluded RNA-recognition motif Ras PF00071.22 EKE39522.1 - 2e-26 92.5 0.2 2.3e-26 92.3 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39522.1 - 1.6e-10 41.2 0.1 3.1e-10 40.3 0.1 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39522.1 - 2.7e-05 23.7 0.1 3.4e-05 23.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.6 EKE39522.1 - 0.00016 22.0 0.1 0.00041 20.6 0.0 1.7 1 1 1 2 2 2 1 AAA domain Septin PF00735.18 EKE39522.1 - 0.00022 20.6 0.0 0.00033 20.0 0.0 1.2 1 0 0 1 1 1 1 Septin AAA_16 PF13191.6 EKE39522.1 - 0.00022 21.7 0.1 0.00043 20.7 0.0 1.5 2 0 0 2 2 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EKE39522.1 - 0.00066 19.6 0.4 0.0079 16.1 0.1 2.2 2 1 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 EKE39522.1 - 0.0008 19.9 0.0 0.0016 18.9 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA PF00004.29 EKE39522.1 - 0.00083 19.8 0.0 0.0022 18.4 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EKE39522.1 - 0.00089 18.7 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Bacterial TniB protein Bac_DnaA PF00308.18 EKE39522.1 - 0.0039 17.1 0.0 0.0049 16.7 0.0 1.1 1 0 0 1 1 1 1 Bacterial dnaA protein G-alpha PF00503.20 EKE39522.1 - 0.0055 15.9 1.4 0.01 15.0 0.7 1.7 1 1 1 2 2 2 1 G-protein alpha subunit Sigma54_activat PF00158.26 EKE39522.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 EKE39522.1 - 0.013 14.8 0.0 0.024 13.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 EKE39522.1 - 0.014 15.1 0.1 0.027 14.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EKE39522.1 - 0.016 15.0 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 EKE39522.1 - 0.037 13.6 0.1 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NB-ARC PF00931.22 EKE39522.1 - 0.048 12.8 0.1 0.085 12.0 0.1 1.3 1 1 0 1 1 1 0 NB-ARC domain Thymidylate_kin PF02223.17 EKE39522.1 - 0.049 13.3 0.1 3.7 7.2 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase AAA_18 PF13238.6 EKE39522.1 - 0.064 13.8 0.1 0.11 13.0 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKE39522.1 - 0.067 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EKE39522.1 - 0.068 13.3 0.0 0.13 12.4 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EKE39522.1 - 0.075 12.8 0.3 0.21 11.3 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AFG1_ATPase PF03969.16 EKE39522.1 - 0.088 11.7 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 AFG1-like ATPase PduV-EutP PF10662.9 EKE39522.1 - 0.11 12.3 0.3 0.14 11.9 0.3 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sec-ASP3 PF15432.6 EKE39522.1 - 0.11 12.6 0.3 0.42 10.8 0.1 1.8 2 0 0 2 2 2 0 Accessory Sec secretory system ASP3 AAA_23 PF13476.6 EKE39522.1 - 0.13 12.7 2.1 0.7 10.4 2.1 1.9 1 1 0 1 1 1 0 AAA domain Ras PF00071.22 EKE39523.1 - 8.9e-19 67.7 0.1 1.1e-18 67.4 0.1 1.0 1 0 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 EKE39523.1 - 0.0073 16.2 0.1 0.0093 15.9 0.1 1.1 1 0 0 1 1 1 1 RsgA GTPase Lipase_GDSL_2 PF13472.6 EKE39524.1 - 1.4e-06 28.8 0.0 1.7e-05 25.3 0.0 2.1 1 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EKE39524.1 - 0.00013 22.0 0.0 0.00039 20.4 0.0 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase RNF111_N PF15303.6 EKE39524.1 - 0.018 14.9 0.2 0.026 14.3 0.2 1.2 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase Arkadia N-terminus NPA PF16469.5 EKE39524.1 - 4.5 7.9 13.9 1.4 9.5 3.8 2.5 1 1 1 2 2 2 0 Nematode polyprotein allergen ABA-1 RhoGAP PF00620.27 EKE39525.1 - 2.5e-31 108.6 0.0 5.9e-31 107.4 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain DUF1764 PF08576.10 EKE39525.1 - 0.064 14.2 0.2 0.16 12.9 0.2 1.6 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF599 PF04654.12 EKE39526.1 - 0.0047 16.4 0.6 0.68 9.3 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function, DUF599 DUF1825 PF08855.10 EKE39526.1 - 0.094 12.6 0.4 0.14 12.1 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1825) DUF2721 PF11026.8 EKE39526.1 - 4.1 7.3 8.1 5.9 6.8 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) NT-C2 PF10358.9 EKE39527.1 - 4.8e-20 71.8 0.2 4.8e-20 71.8 0.2 4.6 3 1 1 4 4 4 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 EKE39527.1 - 1e-13 51.4 4.2 1.1e-13 51.4 0.3 3.1 3 0 0 3 3 3 1 DIL domain Biliv-reduc_cat PF09166.10 EKE39528.1 - 0.0043 17.3 0.4 0.01 16.1 0.4 1.5 1 0 0 1 1 1 1 Biliverdin reductase, catalytic SHNi-TPR PF10516.9 EKE39529.1 - 0.21 11.1 3.7 0.43 10.1 0.4 3.2 3 0 0 3 3 3 0 SHNi-TPR MtrB PF05440.12 EKE39529.1 - 0.42 11.1 2.3 6.2 7.3 0.2 3.7 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B DUF2428 PF10350.9 EKE39530.1 - 2.1e-09 37.1 0.1 9.2e-09 34.9 0.1 2.2 1 1 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) BCLP PF12304.8 EKE39530.1 - 2.8 7.5 7.1 2 8.0 0.2 2.5 2 0 0 2 2 2 0 Beta-casein like protein PAP2 PF01569.21 EKE39531.1 - 0.00053 19.8 3.5 0.00053 19.8 3.5 3.0 3 1 0 3 3 3 1 PAP2 superfamily Bestrophin PF01062.21 EKE39531.1 - 0.81 9.0 11.9 0.03 13.7 5.3 2.0 2 0 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel RRM_1 PF00076.22 EKE39532.1 - 4.1e-81 266.8 15.3 8.3e-19 67.2 0.1 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE39532.1 - 2e-09 37.3 1.6 0.61 10.1 0.0 5.5 5 0 0 5 5 5 3 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EKE39532.1 - 1.1e-08 34.7 3.4 0.0097 15.5 0.0 5.0 4 1 1 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKE39532.1 - 8.7e-07 28.7 3.6 0.19 11.6 0.0 5.5 5 1 0 5 5 5 2 Occluded RNA-recognition motif RRM_2 PF04059.12 EKE39532.1 - 0.00012 22.2 4.7 0.091 13.0 0.2 4.0 4 0 0 4 4 4 2 RNA recognition motif 2 RRM_7 PF16367.5 EKE39532.1 - 0.00058 19.9 1.9 2.1 8.5 0.0 4.8 5 0 0 5 5 5 1 RNA recognition motif DMRT-like PF15791.5 EKE39532.1 - 0.17 12.3 0.0 0.52 10.7 0.0 1.8 1 0 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 MGS PF02142.22 EKE39532.1 - 0.71 10.1 0.1 0.71 10.1 0.1 3.4 4 0 0 4 4 4 0 MGS-like domain Ribosomal_L35Ae PF01247.18 EKE39533.1 - 3.2e-37 126.6 0.3 3.6e-37 126.4 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EKE39533.1 - 0.028 14.6 0.0 0.4 10.9 0.0 2.1 2 0 0 2 2 2 0 RimM N-terminal domain Pkinase PF00069.25 EKE39534.1 - 8.4e-71 238.4 0.5 1.1e-70 238.0 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39534.1 - 3.6e-39 134.6 0.1 4.7e-39 134.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EKE39534.1 - 1.5e-12 47.7 1.2 3.5e-12 46.5 1.2 1.7 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 EKE39534.1 - 5.4e-08 32.5 0.0 9.1e-08 31.8 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Yop-YscD_cpl PF16697.5 EKE39534.1 - 0.00013 22.2 0.0 0.0003 21.0 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FTA2 PF13095.6 EKE39534.1 - 0.0039 16.8 0.2 2.2 7.9 0.1 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EKE39534.1 - 0.0089 15.4 0.4 0.019 14.3 0.4 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EKE39534.1 - 0.0095 15.6 0.2 0.026 14.1 0.2 1.6 1 1 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.9 EKE39534.1 - 0.041 13.4 0.9 0.24 10.9 0.0 2.4 2 2 0 2 2 2 0 PhoP regulatory network protein YrbL APH PF01636.23 EKE39534.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family DENN PF02141.21 EKE39535.1 - 9.2e-19 68.1 7.3 9.2e-19 68.1 7.3 1.7 2 0 0 2 2 2 1 DENN (AEX-3) domain rve PF00665.26 EKE39535.1 - 0.0011 19.1 0.1 0.0065 16.7 0.1 2.0 2 0 0 2 2 2 1 Integrase core domain SPA PF08616.10 EKE39535.1 - 0.018 15.0 1.1 0.043 13.8 1.1 1.7 1 0 0 1 1 1 0 Stabilization of polarity axis TGT_C1 PF14809.6 EKE39535.1 - 0.11 12.8 1.7 2 8.8 0.0 3.2 3 0 0 3 3 3 0 C1 domain of tRNA-guanine transglycosylase dimerisation ArAE_1 PF06081.11 EKE39535.1 - 0.33 11.1 3.2 0.21 11.7 1.4 1.7 2 0 0 2 2 2 0 Aromatic acid exporter family member 1 HA2 PF04408.23 EKE39536.1 - 2.5e-18 66.3 0.1 4.8e-18 65.4 0.1 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EKE39536.1 - 8.1e-15 55.0 0.1 2e-14 53.7 0.1 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EKE39536.1 - 2.1e-14 53.8 0.0 5.6e-14 52.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EKE39536.1 - 1.1e-08 35.1 0.2 2.2e-08 34.1 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EKE39536.1 - 0.00036 20.8 0.3 0.001 19.4 0.3 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EKE39536.1 - 0.0036 17.8 0.2 0.019 15.5 0.2 2.1 1 1 0 1 1 1 1 ABC transporter Flavi_DEAD PF07652.14 EKE39536.1 - 0.0067 16.4 0.1 0.015 15.3 0.1 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain ResIII PF04851.15 EKE39536.1 - 0.0088 16.1 0.6 0.63 10.0 0.1 3.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EKE39536.1 - 0.011 16.1 0.1 0.024 15.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EKE39536.1 - 0.015 14.4 0.0 0.034 13.2 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 EKE39536.1 - 0.051 12.9 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 EKE39536.1 - 0.098 12.6 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase IstB_IS21 PF01695.17 EKE39536.1 - 0.11 12.2 0.0 5.8 6.6 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein Vps39_2 PF10367.9 EKE39537.1 - 0.019 15.4 0.8 0.026 15.0 0.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 ParcG PF10274.9 EKE39537.1 - 0.021 14.9 0.1 0.028 14.5 0.1 1.1 1 0 0 1 1 1 0 Parkin co-regulated protein C1_2 PF03107.16 EKE39537.1 - 0.11 12.9 5.0 0.2 12.0 5.0 1.6 1 1 0 1 1 1 0 C1 domain Endonuclease_7 PF02945.15 EKE39537.1 - 0.33 10.9 4.4 0.83 9.6 4.4 1.8 1 1 0 1 1 1 0 Recombination endonuclease VII Med6 PF04934.14 EKE39539.1 - 2.4e-07 30.6 0.8 6.2e-07 29.3 0.8 1.6 1 1 0 1 1 1 1 MED6 mediator sub complex component DNA_pol_phi PF04931.13 EKE39540.1 - 9.8e-44 149.6 41.3 1e-31 109.9 11.5 3.5 1 1 2 3 3 3 3 DNA polymerase phi DUF913 PF06025.12 EKE39540.1 - 0.12 11.4 3.6 0.053 12.5 0.9 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Pkinase PF00069.25 EKE39542.1 - 2.6e-61 207.3 0.2 4.2e-61 206.6 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39542.1 - 2.1e-50 171.4 0.1 3.3e-50 170.8 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE39542.1 - 4.9e-28 97.7 16.6 9.3e-14 51.8 1.0 3.7 3 0 0 3 3 3 3 PH domain Pkinase_fungal PF17667.1 EKE39542.1 - 2.6e-08 33.1 0.1 1.1e-07 31.0 0.0 2.0 1 1 1 2 2 2 1 Fungal protein kinase PH_11 PF15413.6 EKE39542.1 - 1.8e-06 28.3 10.3 0.0007 20.0 3.1 3.9 3 1 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 EKE39542.1 - 2.6e-06 27.6 1.0 0.0033 17.7 0.1 3.0 2 0 0 2 2 2 2 Pleckstrin homology domain Kinase-like PF14531.6 EKE39542.1 - 1e-05 25.0 0.0 6.1e-05 22.5 0.0 2.1 2 1 0 2 2 2 1 Kinase-like PH_3 PF14593.6 EKE39542.1 - 7.5e-05 22.8 9.2 0.0024 18.0 1.0 3.7 2 1 1 3 3 3 1 PH domain Kdo PF06293.14 EKE39542.1 - 0.0089 15.4 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1356 PF07092.12 EKE39542.1 - 0.015 14.6 0.3 0.03 13.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) PH_4 PF15404.6 EKE39542.1 - 0.044 13.6 2.0 1 9.1 0.0 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain PBD PF00786.28 EKE39542.1 - 0.05 14.0 0.1 0.15 12.4 0.1 1.8 1 0 0 1 1 1 0 P21-Rho-binding domain Rad60-SLD PF11976.8 EKE39542.1 - 0.087 12.7 0.5 0.29 11.0 0.5 1.9 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like PH_2 PF08458.10 EKE39542.1 - 0.12 12.7 5.0 0.97 9.8 0.3 3.9 4 1 0 4 4 4 0 Plant pleckstrin homology-like region PEX-1N PF09262.11 EKE39543.1 - 0.16 12.4 0.4 2.1 8.9 0.0 3.0 3 1 0 3 3 3 0 Peroxisome biogenesis factor 1, N-terminal Alkyl_sulf_dimr PF14863.6 EKE39547.1 - 3.3e-56 189.6 0.6 5.7e-56 188.8 0.6 1.4 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Lactamase_B PF00753.27 EKE39547.1 - 1.4e-20 74.1 0.0 8.8e-19 68.3 0.0 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Alkyl_sulf_C PF14864.6 EKE39547.1 - 1.1e-19 71.0 0.1 2.1e-19 70.0 0.1 1.5 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Lactamase_B_2 PF12706.7 EKE39547.1 - 1.8e-05 24.3 0.0 3.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain ANAPC3 PF12895.7 EKE39547.1 - 0.0037 17.4 0.1 0.013 15.7 0.1 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 SCP2 PF02036.17 EKE39547.1 - 0.0065 16.9 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family Metallophos PF00149.28 EKE39548.1 - 3e-29 103.0 0.1 9.4e-29 101.4 0.1 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase ALMT PF11744.8 EKE39549.1 - 0.33 9.7 12.2 0.5 9.1 12.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter FAD_SOX PF18371.1 EKE39550.1 - 0.095 13.1 0.1 1.9 8.9 0.0 3.4 2 0 0 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase HTH_19 PF12844.7 EKE39551.1 - 0.01 15.8 0.3 0.033 14.2 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_3 PF01381.22 EKE39551.1 - 0.014 15.4 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix Pkinase PF00069.25 EKE39552.1 - 2.6e-35 122.0 1.7 6.6e-35 120.8 0.1 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39552.1 - 4.3e-22 78.6 0.0 8.8e-22 77.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EKE39552.1 - 0.13 12.1 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family PIN PF01850.21 EKE39552.1 - 0.32 11.5 2.0 4.5 7.8 0.0 2.7 3 0 0 3 3 3 0 PIN domain Ground-like PF04155.18 EKE39552.1 - 0.54 11.0 3.6 9 7.0 0.1 3.7 4 0 0 4 4 4 0 Ground-like domain DUF5582 PF17819.1 EKE39553.1 - 3.3 8.2 9.2 7 7.1 2.2 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5582) MgrB PF13998.6 EKE39554.1 - 0.02 14.8 0.2 2.5 8.1 0.0 2.6 2 0 0 2 2 2 0 MgrB protein DUF2672 PF10878.8 EKE39555.1 - 0.0091 15.9 0.1 0.022 14.7 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2672) EF-hand_7 PF13499.6 EKE39556.1 - 6.3e-16 58.6 7.6 2.8e-07 30.9 0.8 3.9 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 EKE39556.1 - 1.4e-13 49.3 8.7 0.00086 18.7 0.0 6.2 8 0 0 8 8 8 3 EF hand EF-hand_6 PF13405.6 EKE39556.1 - 2.7e-12 45.6 6.2 0.032 14.1 0.0 6.7 7 0 0 7 7 7 3 EF-hand domain EF-hand_5 PF13202.6 EKE39556.1 - 2.4e-08 33.1 1.4 0.065 12.8 0.1 4.0 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EKE39556.1 - 6.2e-06 26.0 8.7 0.25 11.2 0.4 5.5 5 1 1 6 6 6 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EKE39556.1 - 0.0053 17.1 3.4 0.4 11.0 0.2 3.2 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EKE39556.1 - 0.16 11.9 1.8 1.8 8.6 0.2 2.8 2 2 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand SinI PF08671.10 EKE39556.1 - 3.9 7.4 4.8 9.7 6.1 0.1 3.3 3 1 0 3 3 3 0 Anti-repressor SinI tRNA_m1G_MT PF01746.21 EKE39557.1 - 8.7e-17 61.5 0.1 8.7e-17 61.5 0.1 1.8 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase PIEZO PF15917.5 EKE39557.1 - 0.12 11.8 8.7 0.2 11.1 8.7 1.3 1 0 0 1 1 1 0 Piezo PglD_N PF17836.1 EKE39557.1 - 0.66 10.7 3.0 1.2 9.8 0.0 2.8 2 2 1 3 3 3 0 PglD N-terminal domain DUF1765 PF08578.10 EKE39558.1 - 9.1e-16 58.5 7.3 9.1e-16 58.5 7.3 3.7 4 1 0 4 4 4 2 Protein of unknown function (DUF1765) Trs65 PF12735.7 EKE39559.1 - 0.071 12.5 9.6 0.51 9.7 0.0 3.7 2 1 1 3 3 3 0 TRAPP trafficking subunit Trs65 STT3 PF02516.14 EKE39560.1 - 4.4e-108 362.3 39.5 4.8e-104 349.0 35.8 2.1 1 1 1 2 2 2 2 Oligosaccharyl transferase STT3 subunit DUF2207 PF09972.9 EKE39560.1 - 0.016 14.0 0.6 0.016 14.0 0.6 3.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Orf78 PF06024.12 EKE39560.1 - 0.024 14.9 0.9 0.024 14.9 0.9 2.9 3 0 0 3 3 3 0 Orf78 (ac78) TMCO5 PF14992.6 EKE39560.1 - 0.059 12.9 4.5 0.12 12.0 4.5 1.4 1 0 0 1 1 1 0 TMCO5 family DUF4711 PF15829.5 EKE39560.1 - 0.094 12.7 2.8 0.16 11.9 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) Pox_EPC_I2-L1 PF12575.8 EKE39560.1 - 0.29 11.4 11.6 0.95 9.7 0.4 4.5 4 0 0 4 4 4 0 Poxvirus entry protein complex L1 and I2 Calcyon PF06387.11 EKE39560.1 - 0.29 11.1 4.4 0.079 12.9 0.7 1.9 2 0 0 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) tRNA-synt_2d PF01409.20 EKE39561.1 - 5e-85 284.9 0.0 6.6e-85 284.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EKE39561.1 - 2.6e-10 40.4 0.0 6.7e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 PheRS DNA binding domain 3 tRNA-synt_2b PF00587.25 EKE39561.1 - 0.00011 22.3 0.0 0.00041 20.4 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_synthFbeta PF17759.1 EKE39561.1 - 0.00019 20.9 0.0 0.0012 18.3 0.0 2.0 2 0 0 2 2 2 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 EKE39561.1 - 0.0026 16.9 3.3 0.023 13.8 0.1 3.3 3 1 0 4 4 4 1 tRNA synthetases class II (D, K and N) PheRS_DBD1 PF18552.1 EKE39561.1 - 0.0048 16.6 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 PheRS DNA binding domain 1 Bac_surface_Ag PF01103.23 EKE39562.1 - 8.1e-09 35.4 0.1 1.3e-08 34.8 0.1 1.3 1 0 0 1 1 1 1 Surface antigen DUF4030 PF13222.6 EKE39562.1 - 0.16 12.1 2.2 6 7.0 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4030) PCI PF01399.27 EKE39563.1 - 6.4e-12 45.9 2.1 2.5e-11 44.0 0.5 2.2 2 1 0 2 2 2 1 PCI domain Pkinase PF00069.25 EKE39564.1 - 3.1e-64 216.9 0.7 8.5e-64 215.5 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39564.1 - 3.3e-33 115.1 0.0 7e-33 114.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE39564.1 - 5.5e-09 36.5 0.1 2.8e-08 34.2 0.1 2.3 1 0 0 1 1 1 1 PH domain APH PF01636.23 EKE39564.1 - 2.2e-06 27.8 0.0 0.019 14.9 0.3 2.2 1 1 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EKE39564.1 - 0.013 14.9 0.0 0.033 13.5 0.0 1.8 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 EKE39564.1 - 0.016 14.8 0.0 0.052 13.1 0.0 1.8 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 EKE39564.1 - 0.084 12.2 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PH_9 PF15410.6 EKE39564.1 - 0.15 12.4 1.0 3.7 7.9 1.0 2.8 1 1 0 1 1 1 0 Pleckstrin homology domain zinc_ribbon_10 PF10058.9 EKE39564.1 - 0.52 10.1 6.4 1.9 8.3 6.4 2.0 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein DUF1765 PF08578.10 EKE39565.1 - 5.3e-20 72.1 16.0 5.3e-20 72.1 16.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) Sld5 PF05916.11 EKE39565.1 - 0.003 18.0 0.1 0.023 15.1 0.1 2.5 2 1 0 2 2 2 1 GINS complex protein Pkinase_Tyr PF07714.17 EKE39568.1 - 9.5e-39 133.2 0.1 2e-38 132.2 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE39568.1 - 9.8e-35 120.2 0.6 4.9e-34 117.9 0.2 2.4 2 0 0 2 2 2 1 Protein kinase domain LRR_4 PF12799.7 EKE39568.1 - 1.3e-13 50.9 39.9 9e-05 22.8 8.7 7.4 5 1 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE39568.1 - 1.9e-12 46.7 30.0 3.5e-07 29.9 7.0 5.4 2 2 2 5 5 5 4 Leucine rich repeat Myotub-related PF06602.14 EKE39568.1 - 1.2e-07 31.0 2.7 3.9e-07 29.3 2.2 2.1 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain LRR_1 PF00560.33 EKE39568.1 - 1.5 9.7 33.4 17 6.5 0.7 9.9 9 1 0 9 9 9 0 Leucine Rich Repeat Pkinase_Tyr PF07714.17 EKE39569.1 - 1.7e-45 155.3 0.0 5e-45 153.8 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE39569.1 - 5.8e-40 137.3 0.0 1.4e-39 136.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EKE39569.1 - 7.6e-14 52.1 15.8 5.5e-05 23.7 0.7 3.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE39569.1 - 6.8e-13 48.9 1.5 0.0032 18.0 0.0 5.2 1 1 4 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE39569.1 - 5.7e-11 42.4 3.5 1.1e-05 25.5 0.7 4.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE39569.1 - 2.3e-08 33.6 2.2 0.05 14.2 0.1 5.9 6 0 0 6 6 6 2 Ankyrin repeat Ank PF00023.30 EKE39569.1 - 5.7e-07 29.7 2.2 0.5 10.9 0.1 4.9 3 1 0 3 3 3 2 Ankyrin repeat OSCP PF00213.18 EKE39569.1 - 0.059 13.5 1.6 0.32 11.1 0.1 2.4 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit CCDC84 PF14968.6 EKE39569.1 - 0.23 11.0 1.8 0.39 10.3 1.8 1.3 1 0 0 1 1 1 0 Coiled coil protein 84 P-II PF00543.22 EKE39569.1 - 0.48 11.1 2.3 0.85 10.3 0.6 2.2 2 0 0 2 2 2 0 Nitrogen regulatory protein P-II NAP PF00956.18 EKE39570.1 - 1.8e-22 79.8 18.8 3.3e-19 69.1 18.8 2.1 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) Metal_resist PF13801.6 EKE39570.1 - 0.089 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Heavy-metal resistance Sec7 PF01369.20 EKE39571.1 - 2e-44 151.5 5.8 2e-44 151.5 5.8 3.2 5 0 0 5 5 5 1 Sec7 domain Sec7_N PF12783.7 EKE39571.1 - 6.7e-13 48.8 1.1 6.7e-13 48.8 1.1 3.2 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EKE39571.1 - 3.3e-05 23.7 9.9 4.9e-05 23.1 0.2 4.3 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) zf-MYND PF01753.18 EKE39571.1 - 0.00069 19.6 10.1 0.0021 18.1 10.1 1.8 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 EKE39571.1 - 0.004 17.0 8.5 0.004 17.0 8.5 2.1 2 0 0 2 2 2 1 HIT zinc finger Vac14_Fab1_bd PF12755.7 EKE39571.1 - 0.052 14.1 0.1 0.42 11.2 0.1 2.8 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region PLATZ PF04640.14 EKE39571.1 - 0.37 11.5 6.8 0.71 10.5 3.3 3.1 2 0 0 2 2 2 0 PLATZ transcription factor Ras PF00071.22 EKE39573.1 - 8.5e-49 165.3 1.3 9.8e-49 165.1 1.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39573.1 - 2.1e-30 105.4 0.6 2.9e-30 104.9 0.6 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39573.1 - 4.7e-20 71.8 0.7 5.7e-20 71.5 0.7 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE39573.1 - 4.1e-07 29.6 0.2 4.9e-07 29.3 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EKE39573.1 - 8.2e-06 25.4 0.1 1.1e-05 24.9 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE39573.1 - 0.00014 21.5 1.2 0.0012 18.4 1.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE39573.1 - 0.0002 21.4 0.1 0.00029 20.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 EKE39573.1 - 0.00029 20.4 0.1 0.00065 19.3 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EKE39573.1 - 0.00057 19.8 2.0 0.079 12.9 0.6 2.2 1 1 0 2 2 2 2 RsgA GTPase ATPase_2 PF01637.18 EKE39573.1 - 0.0081 16.1 0.1 0.011 15.7 0.1 1.1 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EKE39573.1 - 0.03 14.9 0.3 0.045 14.3 0.3 1.3 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EKE39573.1 - 0.041 14.3 0.0 0.057 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EKE39573.1 - 0.09 13.0 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 EKE39573.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain PduV-EutP PF10662.9 EKE39573.1 - 0.16 11.7 1.1 0.5 10.1 1.1 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Rib_5-P_isom_A PF06026.14 EKE39574.1 - 0.057 13.0 0.1 0.066 12.8 0.1 1.2 1 0 0 1 1 1 0 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) CdvA PF18822.1 EKE39574.1 - 0.29 11.0 4.6 0.13 12.1 0.6 2.2 2 1 0 2 2 2 0 CdvA-like coiled-coil domain CorA PF01544.18 EKE39574.1 - 0.67 9.2 3.5 1 8.6 3.5 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Pkinase_Tyr PF07714.17 EKE39575.1 - 3.1e-34 118.4 0.2 6.3e-34 117.4 0.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE39575.1 - 4.1e-29 101.7 0.1 4.1e-29 101.7 0.1 2.3 2 1 0 2 2 2 1 Protein kinase domain LRR_8 PF13855.6 EKE39575.1 - 3.9e-15 55.3 27.2 1.6e-07 31.0 0.8 4.1 2 1 2 4 4 4 4 Leucine rich repeat Myotub-related PF06602.14 EKE39575.1 - 9.4e-15 54.4 4.2 3.5e-14 52.5 4.2 1.9 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain LRR_4 PF12799.7 EKE39575.1 - 3e-11 43.3 38.0 0.0002 21.6 4.7 6.4 2 2 4 6 6 6 4 Leucine Rich repeats (2 copies) RhoGAP PF00620.27 EKE39575.1 - 6.4e-05 22.8 0.1 0.00029 20.7 0.1 2.1 1 0 0 1 1 1 1 RhoGAP domain GRAM PF02893.20 EKE39575.1 - 0.00061 19.6 1.9 0.0047 16.8 0.3 3.5 2 0 0 2 2 2 1 GRAM domain Kdo PF06293.14 EKE39575.1 - 0.0043 16.4 0.0 0.0081 15.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_1 PF00560.33 EKE39575.1 - 0.016 15.7 26.6 3.6 8.5 0.1 8.8 8 0 0 8 8 8 0 Leucine Rich Repeat XRN_M PF17846.1 EKE39576.1 - 2.8e-08 33.2 5.2 1.6e-06 27.3 1.6 2.3 1 1 1 2 2 2 2 Xrn1 helical domain TetR_C_13 PF16925.5 EKE39576.1 - 0.006 16.5 0.5 0.014 15.3 0.5 1.6 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TLD PF07534.16 EKE39577.1 - 1.2e-06 28.8 0.2 1.8e-06 28.2 0.2 1.4 1 0 0 1 1 1 1 TLD YppF PF14178.6 EKE39577.1 - 0.043 13.7 3.4 0.091 12.6 3.4 1.6 1 0 0 1 1 1 0 YppF-like protein CCDC-167 PF15188.6 EKE39577.1 - 0.21 11.9 9.3 0.48 10.8 9.3 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 RRM_1 PF00076.22 EKE39578.1 - 1.7e-21 75.8 0.5 2.5e-21 75.2 0.5 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 EKE39578.1 - 0.0052 16.4 1.0 0.024 14.3 1.0 2.1 1 1 0 1 1 1 1 Ribonuclease B OB domain RRM_occluded PF16842.5 EKE39578.1 - 0.016 15.0 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif SET_assoc PF11767.8 EKE39578.1 - 0.017 14.8 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated Nup35_RRM_2 PF14605.6 EKE39578.1 - 0.044 13.8 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EKE39578.1 - 0.05 13.2 0.0 0.072 12.7 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EKE39578.1 - 0.068 13.2 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 RNA binding motif Macoilin PF09726.9 EKE39578.1 - 1.1 7.8 14.2 1.1 7.7 14.2 1.0 1 0 0 1 1 1 0 Macoilin family PP2C_2 PF13672.6 EKE39580.1 - 4.2e-07 29.8 0.0 1.1e-06 28.4 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE39580.1 - 0.015 15.2 0.0 0.028 14.4 0.0 1.4 1 1 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) SecE PF00584.20 EKE39582.1 - 1e-14 54.1 0.0 1.2e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex CPSF_A PF03178.15 EKE39583.1 - 8e-43 147.0 0.2 8e-42 143.7 0.0 2.7 2 1 0 3 3 3 1 CPSF A subunit region MMS1_N PF10433.9 EKE39583.1 - 2.8e-35 121.9 7.1 5.4e-35 121.0 7.1 1.5 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CAF1 PF04857.20 EKE39584.1 - 4.2e-22 78.7 3.3 8e-12 45.0 0.3 2.7 1 1 0 2 2 2 2 CAF1 family ribonuclease Mucin PF01456.17 EKE39585.1 - 0.0099 15.9 3.3 0.0099 15.9 3.3 1.7 1 1 1 2 2 2 1 Mucin-like glycoprotein Helicase_C_2 PF13307.6 EKE39586.1 - 3e-44 151.2 0.0 5.4e-44 150.4 0.0 1.4 1 0 0 1 1 1 1 Helicase C-terminal domain HBB PF06777.11 EKE39586.1 - 4e-08 33.2 0.3 0.00014 21.6 0.0 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain DEAD_2 PF06733.15 EKE39586.1 - 0.0045 16.6 0.1 0.02 14.6 0.1 2.2 2 0 0 2 2 2 1 DEAD_2 DEAD_2 PF06733.15 EKE39587.1 - 2.9e-16 59.6 0.9 3.5e-16 59.3 0.9 1.2 1 0 0 1 1 1 1 DEAD_2 AAA_19 PF13245.6 EKE39587.1 - 0.0066 16.8 0.0 0.0073 16.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EKE39587.1 - 0.028 14.4 0.0 0.028 14.4 0.0 1.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DEAD PF00270.29 EKE39587.1 - 0.041 13.6 0.0 0.052 13.3 0.0 1.1 1 0 0 1 1 1 0 DEAD/DEAH box helicase HSP70 PF00012.20 EKE39588.1 - 3e-126 422.0 15.2 2e-123 412.7 5.8 3.0 1 1 2 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.13 EKE39588.1 - 6.5e-09 35.0 5.3 2e-08 33.4 0.1 3.5 3 1 0 3 3 3 1 MreB/Mbl protein TPP_enzyme_N PF02776.18 EKE39588.1 - 0.061 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain EP400_N PF15790.5 EKE39588.1 - 1.9 7.2 4.9 3.1 6.5 4.9 1.2 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal TERB2 PF15101.6 EKE39588.1 - 2.7 8.0 15.7 4.8 7.2 2.3 2.4 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF2514 PF10721.9 EKE39588.1 - 7.7 6.5 9.8 21 5.1 9.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) TEX19 PF15553.6 EKE39588.1 - 9.2 6.2 7.3 1.6 8.7 0.2 2.3 2 0 0 2 2 2 0 Testis-expressed protein 19 Ank_2 PF12796.7 EKE39589.1 - 2.1e-48 162.8 13.3 3.2e-09 37.3 0.0 7.3 2 2 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE39589.1 - 1.7e-34 117.7 6.1 0.00018 22.0 0.0 10.1 7 2 3 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE39589.1 - 3.5e-31 103.7 9.7 0.0096 16.4 0.1 12.2 12 0 0 12 12 12 7 Ankyrin repeat Ank_5 PF13857.6 EKE39589.1 - 4.2e-29 100.2 2.6 3.9e-05 23.9 0.0 10.9 5 3 6 12 12 12 6 Ankyrin repeats (many copies) Ank PF00023.30 EKE39589.1 - 5.8e-26 89.8 10.3 0.0035 17.7 0.3 10.5 10 0 0 10 10 10 7 Ankyrin repeat zf-RING_2 PF13639.6 EKE39590.1 - 4.1e-09 36.6 11.9 5.7e-09 36.2 10.9 1.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 EKE39590.1 - 1.6e-08 34.1 7.9 1.6e-08 34.1 7.9 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 EKE39590.1 - 7.8e-06 25.8 10.2 7.8e-06 25.8 10.2 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EKE39590.1 - 0.0001 22.2 9.3 0.00028 20.8 6.9 2.5 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EKE39590.1 - 0.00048 20.0 10.8 0.00048 20.0 10.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE39590.1 - 0.004 17.0 10.7 0.004 17.0 10.7 2.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EKE39590.1 - 0.0043 17.1 3.8 0.009 16.0 3.8 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EKE39590.1 - 0.013 15.7 8.8 0.052 13.9 8.8 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EKE39590.1 - 0.015 15.2 9.9 0.034 14.0 9.9 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn-C2H2_12 PF18112.1 EKE39590.1 - 0.06 13.8 0.2 0.36 11.3 0.1 2.4 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain TP_methylase PF00590.20 EKE39591.1 - 1.1e-22 81.1 0.0 1.4e-22 80.7 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases UPF0113 PF03657.13 EKE39591.1 - 0.0029 17.8 0.3 0.039 14.2 0.1 2.7 2 1 0 2 2 2 1 UPF0113 PUA domain EMP24_GP25L PF01105.24 EKE39591.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD PH PF00169.29 EKE39592.1 - 5.3e-12 46.2 0.7 1.8e-11 44.4 0.1 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EKE39592.1 - 0.0022 18.4 0.1 0.0022 18.4 0.1 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EKE39592.1 - 0.0026 18.0 0.0 0.0053 17.0 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain DUF1493 PF07377.12 EKE39592.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) Tetraspanin PF00335.20 EKE39593.1 - 0.0039 16.9 11.2 0.0039 16.9 11.2 2.0 1 1 0 2 2 2 1 Tetraspanin family DUF2981 PF11200.8 EKE39593.1 - 0.27 10.9 2.2 0.35 10.6 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) CD20 PF04103.15 EKE39593.1 - 2.6 8.1 17.2 0.34 11.0 7.1 2.5 1 1 1 2 2 2 0 CD20-like family Peptidase_M20 PF01546.28 EKE39595.1 - 1e-13 51.5 0.0 1.7e-13 50.8 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EKE39595.1 - 5.8e-05 22.3 0.4 1.1 8.2 0.0 3.2 3 0 0 3 3 3 3 M42 glutamyl aminopeptidase ACTH_assoc PF16102.5 EKE39595.1 - 0.36 11.7 1.2 0.62 11.0 0.2 2.0 2 0 0 2 2 2 0 ACTH-associated domain Pkinase PF00069.25 EKE39596.1 - 5.3e-58 196.5 1.3 6.6e-58 196.1 1.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39596.1 - 1.5e-29 103.1 0.5 3.3e-29 102.0 0.4 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE39596.1 - 0.00032 20.1 0.0 0.0005 19.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKE39596.1 - 0.0019 17.6 0.3 0.0041 16.5 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKE39596.1 - 0.0074 15.1 0.3 0.012 14.4 0.2 1.3 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKE39596.1 - 0.01 15.8 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EKE39596.1 - 0.011 15.4 3.3 0.017 14.8 3.3 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase TLD PF07534.16 EKE39597.1 - 0.00015 22.0 0.1 0.00025 21.3 0.1 1.4 1 0 0 1 1 1 1 TLD M11L PF11099.8 EKE39597.1 - 0.053 13.8 1.9 0.069 13.4 0.3 1.8 2 0 0 2 2 2 0 Apoptosis regulator M11L like Desmo_N PF06771.11 EKE39597.1 - 0.2 12.1 0.8 6.1 7.3 0.1 2.3 2 0 0 2 2 2 0 Viral Desmoplakin N-terminus CheR_N PF03705.15 EKE39598.1 - 0.13 12.0 0.2 25 4.7 0.0 2.7 2 0 0 2 2 2 0 CheR methyltransferase, all-alpha domain Na_H_Exchanger PF00999.21 EKE39599.1 - 8.8e-53 179.5 48.8 1.1e-52 179.1 48.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Phage_holin_3_3 PF16083.5 EKE39599.1 - 0.069 13.3 0.2 0.069 13.3 0.2 3.9 3 1 1 4 4 4 0 LydA holin phage, holin superfamily III Metallophos PF00149.28 EKE39600.1 - 2.7e-37 129.3 0.1 3.3e-37 129.0 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EKE39600.1 - 4.9e-05 23.7 1.9 6.1e-05 23.4 0.5 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain LacAB_rpiB PF02502.18 EKE39602.1 - 7.1e-56 188.1 0.6 7.9e-56 187.9 0.6 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase Fer4_18 PF13746.6 EKE39602.1 - 0.06 13.6 0.5 0.072 13.3 0.5 1.2 1 0 0 1 1 1 0 4Fe-4S dicluster domain DUF2024 PF09630.10 EKE39602.1 - 0.072 13.0 0.2 4.9 7.1 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF2024) PTS_IIB PF02302.17 EKE39602.1 - 0.22 12.2 1.2 2.3 9.0 1.1 2.6 2 1 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIB subunit Profilin PF00235.19 EKE39603.1 - 6.5e-32 110.5 2.7 7.2e-32 110.3 2.7 1.0 1 0 0 1 1 1 1 Profilin Lyase_1 PF00206.20 EKE39604.1 - 8.3e-92 307.9 0.0 1e-91 307.6 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EKE39604.1 - 6.9e-21 74.4 0.2 2e-20 72.9 0.2 1.8 1 0 0 1 1 1 1 Fumarase C C-terminus SH3_17 PF18350.1 EKE39604.1 - 0.07 13.0 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 Restriction endonuclease SH3 domain bZIP_Maf PF03131.17 EKE39605.1 - 0.03 14.8 1.6 0.03 14.8 1.6 2.0 1 1 1 2 2 2 0 bZIP Maf transcription factor UAE_UbL PF14732.6 EKE39605.1 - 0.039 14.5 2.1 0.04 14.5 1.1 1.4 2 0 0 2 2 2 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain ORF6N PF10543.9 EKE39605.1 - 0.098 12.9 3.9 0.14 12.4 3.6 1.6 1 1 0 1 1 1 0 ORF6N domain CaM_bdg_C0 PF10562.9 EKE39605.1 - 0.14 12.2 1.6 0.14 12.2 1.6 1.8 2 0 0 2 2 2 0 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit Antimicrobial_7 PF08102.11 EKE39605.1 - 0.19 12.0 3.1 10 6.4 0.1 2.4 2 1 0 2 2 2 0 Scorpion antimicrobial peptide TFIIA PF03153.13 EKE39606.1 - 6.6 6.6 56.4 8.7 6.2 56.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase_Tyr PF07714.17 EKE39607.1 - 4.9e-36 124.3 0.1 6.3e-36 124.0 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE39607.1 - 2.4e-31 109.1 0.1 3.4e-31 108.6 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Insulin_TMD PF17870.1 EKE39607.1 - 0.049 13.7 0.5 0.1 12.7 0.5 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF4330 PF14221.6 EKE39607.1 - 0.085 13.1 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) Motile_Sperm PF00635.26 EKE39607.1 - 0.086 12.7 0.2 0.19 11.6 0.2 1.6 1 0 0 1 1 1 0 MSP (Major sperm protein) domain EphA2_TM PF14575.6 EKE39607.1 - 0.097 13.6 0.0 0.19 12.6 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RIFIN PF02009.16 EKE39607.1 - 0.96 9.3 5.9 1.2 9.0 3.1 2.2 2 0 0 2 2 2 0 Rifin FbpA PF05833.11 EKE39608.1 - 1.1e-35 123.3 26.6 1.1e-35 123.3 26.6 3.1 3 1 0 3 3 3 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 EKE39608.1 - 5.4e-30 104.2 2.2 6.8e-30 103.9 0.0 2.4 2 0 0 2 2 2 1 NFACT protein RNA binding domain NFACT-C PF11923.8 EKE39608.1 - 2.9e-17 62.5 0.1 2.9e-17 62.5 0.1 5.2 4 2 1 5 5 5 1 NFACT protein C-terminal domain zf-CCHC PF00098.23 EKE39608.1 - 9.9e-06 25.4 0.3 2.3e-05 24.3 0.3 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EKE39608.1 - 0.16 11.8 0.2 0.29 11.0 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle Auxin_canalis PF05703.11 EKE39608.1 - 4.5 7.1 7.0 16 5.3 7.0 1.9 1 0 0 1 1 1 0 Auxin canalisation LRR_9 PF14580.6 EKE39609.1 - 0.092 12.2 22.0 0.083 12.4 2.4 4.6 3 1 2 5 5 5 0 Leucine-rich repeat Metalloenzyme PF01676.18 EKE39610.1 - 5.7e-36 124.2 0.0 6.3e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Alk_phosphatase PF00245.20 EKE39610.1 - 0.00016 20.8 0.0 0.0002 20.5 0.0 1.3 1 1 0 1 1 1 1 Alkaline phosphatase Phosphodiest PF01663.22 EKE39610.1 - 0.0027 17.3 0.0 0.0027 17.3 0.0 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PglZ PF08665.12 EKE39610.1 - 0.09 12.9 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 PglZ domain Ras PF00071.22 EKE39611.1 - 4.4e-50 169.4 0.0 5.6e-50 169.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39611.1 - 4.5e-22 78.5 0.0 8.1e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39611.1 - 1.3e-09 37.7 0.0 1.9e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE39611.1 - 0.00027 20.5 0.4 0.021 14.4 0.0 2.3 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE39611.1 - 0.002 18.2 0.0 0.0043 17.1 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FH2 PF02181.23 EKE39612.1 - 5.2e-64 216.7 11.0 5.2e-64 216.7 11.0 2.1 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH1 PF06346.12 EKE39612.1 - 1.2 8.8 24.5 1.7 8.3 24.5 1.2 1 0 0 1 1 1 0 Formin Homology Region 1 GBP_C PF02841.14 EKE39612.1 - 1.8 7.9 28.8 0.96 8.8 26.0 1.9 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Nucleoporin2 PF04096.14 EKE39613.1 - 3.5e-20 72.7 0.1 3.5e-20 72.7 0.1 2.2 2 0 0 2 2 2 1 Nucleoporin autopeptidase ZirS_C PF16583.5 EKE39613.1 - 0.033 13.8 1.8 0.15 11.6 0.6 2.5 2 1 0 2 2 2 0 Zinc-regulated secreted antivirulence protein C-terminal domain Ras PF00071.22 EKE39614.1 - 2.2e-64 215.9 1.2 2.6e-64 215.7 1.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39614.1 - 4e-37 127.1 0.3 9.2e-37 125.9 0.3 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39614.1 - 5e-18 65.1 0.6 6.7e-18 64.8 0.6 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE39614.1 - 1e-08 34.8 0.4 1.2e-08 34.6 0.4 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE39614.1 - 4e-06 26.8 0.3 0.091 12.7 0.2 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EKE39614.1 - 8.4e-06 25.3 0.2 1.5e-05 24.5 0.2 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EKE39614.1 - 1.9e-05 24.7 0.1 2.8e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE39614.1 - 0.00011 21.9 0.5 0.00027 20.6 0.5 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EKE39614.1 - 0.0024 17.4 0.5 0.0053 16.3 0.5 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 EKE39614.1 - 0.0067 16.8 0.0 0.009 16.4 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain Septin PF00735.18 EKE39614.1 - 0.011 15.0 0.1 0.023 14.0 0.0 1.5 2 0 0 2 2 2 0 Septin TniB PF05621.11 EKE39614.1 - 0.023 14.1 0.1 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein AAA PF00004.29 EKE39614.1 - 0.025 15.0 0.2 0.35 11.3 0.2 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EKE39614.1 - 0.043 14.1 0.0 0.089 13.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EKE39614.1 - 0.052 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 EKE39614.1 - 0.053 13.5 0.1 0.12 12.4 0.1 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AEP1 PF17049.5 EKE39614.1 - 0.056 12.5 0.1 0.066 12.3 0.1 1.1 1 0 0 1 1 1 0 ATPase expression protein 1 ABC_tran PF00005.27 EKE39614.1 - 0.077 13.5 0.2 0.12 12.9 0.1 1.6 1 1 0 1 1 1 0 ABC transporter Apyrase PF06079.11 EKE39616.1 - 2.4e-10 40.1 0.0 1.4e-08 34.3 0.0 2.1 1 1 0 1 1 1 1 Apyrase CDC37_M PF08565.11 EKE39617.1 - 2.6e-09 37.0 0.0 3.8e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain LRR_8 PF13855.6 EKE39618.1 - 1.6 8.5 12.5 15 5.4 0.1 4.9 5 0 0 5 5 5 0 Leucine rich repeat LIM PF00412.22 EKE39619.1 - 1.5e-42 143.6 52.5 1.3e-13 51.0 9.3 4.1 4 0 0 4 4 4 4 LIM domain DUF2685 PF10886.8 EKE39619.1 - 0.026 14.7 0.8 0.026 14.7 0.8 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2685) Auto_anti-p27 PF06677.12 EKE39619.1 - 0.037 14.2 0.7 0.037 14.2 0.7 6.0 8 0 0 8 8 8 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 EKE39619.1 - 0.063 13.3 49.1 0.16 12.0 0.8 6.5 2 1 0 2 2 2 0 Double zinc ribbon PNTB PF02233.16 EKE39621.1 - 4.5e-61 207.2 0.5 4.9e-61 207.1 0.5 1.0 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit Tudor-knot PF11717.8 EKE39622.1 - 0.081 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Gcn1_N PF12074.8 EKE39623.1 - 0.0095 15.3 0.1 0.03 13.6 0.1 1.9 2 0 0 2 2 2 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Rhodanese PF00581.20 EKE39625.1 - 6.1e-12 46.0 0.1 9.5e-12 45.4 0.1 1.3 1 0 0 1 1 1 1 Rhodanese-like domain FAD_binding_8 PF08022.12 EKE39625.1 - 0.21 11.7 1.1 1.8 8.7 0.0 2.5 2 1 1 3 3 3 0 FAD-binding domain TMEM154 PF15102.6 EKE39626.1 - 9.9e-06 25.5 3.7 9.9e-06 25.5 3.7 2.2 2 1 0 2 2 2 1 TMEM154 protein family DUF4690 PF15756.5 EKE39626.1 - 1.1e-05 25.9 0.4 2.7e-05 24.7 0.4 1.6 1 0 0 1 1 1 1 Small Novel Rich in Cartilage Podoplanin PF05808.11 EKE39626.1 - 1.2e-05 25.5 3.1 1.9e-05 24.8 2.3 1.8 2 0 0 2 2 2 1 Podoplanin Renin_r PF07850.14 EKE39626.1 - 6.4e-05 23.5 0.8 0.00013 22.5 0.1 1.9 2 0 0 2 2 1 1 Renin receptor-like protein Shisa PF13908.6 EKE39626.1 - 0.00011 22.6 1.1 0.00038 20.8 0.3 2.2 2 1 0 2 2 2 1 Wnt and FGF inhibitory regulator Orf78 PF06024.12 EKE39626.1 - 0.00024 21.4 3.9 0.00024 21.4 3.9 2.4 2 1 0 2 2 2 1 Orf78 (ac78) RIFIN PF02009.16 EKE39626.1 - 0.00033 20.7 0.6 0.0013 18.7 0.0 1.7 1 1 0 2 2 2 1 Rifin DUF4711 PF15829.5 EKE39626.1 - 0.0022 18.0 0.4 0.0022 18.0 0.4 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4711) DUF4366 PF14283.6 EKE39626.1 - 0.0027 17.8 0.3 0.008 16.2 0.3 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4366) Glycophorin_A PF01102.18 EKE39626.1 - 0.0088 16.3 0.3 0.022 15.0 0.3 1.6 1 0 0 1 1 1 1 Glycophorin A DUF2023 PF09633.10 EKE39626.1 - 0.057 13.5 0.4 2.1 8.5 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2023) LRRC37AB_C PF14914.6 EKE39626.1 - 0.25 11.3 2.4 0.16 11.9 0.3 1.8 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain DUF5385 PF17359.2 EKE39626.1 - 0.4 10.2 3.1 0.84 9.1 3.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Insulin_TMD PF17870.1 EKE39626.1 - 0.67 10.1 6.5 2 8.5 6.5 1.8 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF5383 PF17355.2 EKE39626.1 - 4.8 7.6 9.0 1.9 8.8 5.3 2.3 2 1 0 2 2 1 0 Family of unknown function (DUF5383) Nop14 PF04147.12 EKE39626.1 - 7 4.7 11.8 9.2 4.3 11.8 1.1 1 0 0 1 1 1 0 Nop14-like family Macoilin PF09726.9 EKE39626.1 - 8.8 4.7 12.4 11 4.4 12.4 1.2 1 0 0 1 1 1 0 Macoilin family HSP70 PF00012.20 EKE39627.1 - 3.6e-69 233.5 1.0 9.2e-69 232.2 1.0 1.5 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE39627.1 - 1.1e-08 34.3 0.5 1.1e-08 34.3 0.5 3.0 3 1 0 3 3 3 1 MreB/Mbl protein RRM_1 PF00076.22 EKE39628.1 - 7e-08 32.2 0.0 1.3e-06 28.2 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 EKE39628.1 - 4.8e-05 24.0 5.4 0.051 14.3 0.2 2.7 3 0 0 3 3 3 2 Torus domain zf-CCCH PF00642.24 EKE39628.1 - 0.00099 19.0 4.0 0.062 13.2 0.2 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nucleocapsid-N PF11030.8 EKE39628.1 - 0.086 12.8 1.3 0.13 12.2 1.3 1.3 1 0 0 1 1 1 0 Nucleocapsid protein N zf_CCCH_4 PF18345.1 EKE39628.1 - 9.4 6.4 11.6 0.28 11.3 1.3 2.5 2 0 0 2 2 2 0 Zinc finger domain CDC45 PF02724.14 EKE39629.1 - 2 6.6 26.7 2.9 6.1 26.7 1.2 1 0 0 1 1 1 0 CDC45-like protein DcpS_C PF11969.8 EKE39630.1 - 2.2e-17 63.6 1.7 1.5e-16 60.8 0.0 2.5 2 1 1 3 3 3 1 Scavenger mRNA decapping enzyme C-term binding NCBP3 PF10309.9 EKE39630.1 - 0.034 14.0 0.5 2.1 8.3 0.1 2.4 2 0 0 2 2 2 0 Nuclear cap-binding protein subunit 3 Fe-ADH PF00465.19 EKE39631.1 - 4.2e-52 177.2 0.0 4.9e-52 176.9 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Drf_FH3 PF06367.16 EKE39632.1 - 1.2e-10 41.4 2.2 1.2e-10 41.4 2.2 2.2 2 0 0 2 2 2 1 Diaphanous FH3 Domain DRIM PF07539.12 EKE39632.1 - 2.8e-06 26.0 0.1 4.8e-06 25.2 0.1 1.3 1 0 0 1 1 1 1 Down-regulated in metastasis Arm PF00514.23 EKE39632.1 - 0.088 12.9 0.8 30 4.9 0.1 3.4 2 1 0 2 2 2 0 Armadillo/beta-catenin-like repeat DUF4284 PF14112.6 EKE39632.1 - 5.4 8.0 6.5 4 8.4 0.1 3.2 2 1 1 3 3 3 0 Immunity protein 22 DUF1729 PF08354.10 EKE39633.1 - 0.0012 17.8 0.0 0.0015 17.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) DUF3502 PF12010.8 EKE39633.1 - 0.035 14.8 0.9 0.062 14.0 0.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3502) SAM_Exu PF18609.1 EKE39633.1 - 0.25 11.4 0.7 0.47 10.6 0.2 1.7 2 0 0 2 2 2 0 Exuperantia SAM-like domain Dus PF01207.17 EKE39634.1 - 2.6e-67 227.1 0.5 3.1e-67 226.9 0.5 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 EKE39634.1 - 8.6e-07 28.5 0.0 2.2e-06 27.1 0.0 1.6 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase Arm PF00514.23 EKE39635.1 - 0.93 9.6 6.3 1e+02 3.2 0.0 5.3 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat HSF_DNA-bind PF00447.17 EKE39636.1 - 3.1e-26 91.8 4.4 3.4e-26 91.7 2.0 2.1 2 0 0 2 2 2 1 HSF-type DNA-binding YPEB PF14620.6 EKE39636.1 - 0.025 14.0 0.3 0.032 13.6 0.3 1.2 1 0 0 1 1 1 0 YpeB sporulation Flavodoxin_1 PF00258.25 EKE39637.1 - 2.1e-10 41.0 0.0 1.5e-09 38.2 0.0 2.1 1 1 0 1 1 1 1 Flavodoxin Lactamase_B PF00753.27 EKE39637.1 - 5.3e-07 29.8 0.0 1.2e-06 28.7 0.0 1.5 1 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Flavodoxin_5 PF12724.7 EKE39637.1 - 0.00057 20.1 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin domain DUF1256 PF06866.11 EKE39637.1 - 0.006 16.0 0.8 0.36 10.2 0.1 2.6 2 1 1 3 3 3 1 Protein of unknown function (DUF1256) Gal_GalNac_35kD PF17337.2 EKE39638.1 - 2.5e-35 122.5 16.5 4.6e-34 118.4 16.5 2.1 1 1 0 1 1 1 1 Galactose-inhibitable lectin 35 kDa subunit P34-Arc PF04045.14 EKE39638.1 - 0.021 14.5 0.5 0.79 9.4 0.0 2.0 1 1 1 2 2 2 0 Arp2/3 complex, 34 kD subunit p34-Arc Ras PF00071.22 EKE39639.1 - 9.4e-51 171.6 0.5 1.5e-50 171.0 0.5 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39639.1 - 2e-25 89.3 0.1 2e-25 89.3 0.1 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39639.1 - 1.2e-10 41.1 0.0 1.9e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE39639.1 - 1.9e-07 31.1 5.7 0.0026 17.7 0.2 3.5 1 1 3 4 4 4 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE39639.1 - 1.5e-05 25.0 0.3 2.9e-05 24.1 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE39639.1 - 2.1e-05 24.2 0.7 0.0021 17.7 0.1 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKE39639.1 - 8e-05 22.2 1.5 0.0001 21.8 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EKE39639.1 - 0.00064 19.1 0.2 0.00093 18.6 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF5062 PF16691.5 EKE39639.1 - 0.0032 17.6 0.0 0.0052 16.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5062) AAA_22 PF13401.6 EKE39639.1 - 0.0081 16.4 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Septin PF00735.18 EKE39639.1 - 0.01 15.1 0.0 0.01 15.1 0.0 1.8 2 0 0 2 2 2 0 Septin AAA PF00004.29 EKE39639.1 - 0.011 16.1 0.1 0.032 14.7 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CPT PF07931.12 EKE39639.1 - 0.012 15.5 0.1 0.025 14.4 0.1 1.7 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein NACHT PF05729.12 EKE39639.1 - 0.019 14.9 0.0 0.034 14.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 EKE39639.1 - 0.019 15.3 0.1 0.038 14.4 0.1 1.7 1 1 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 EKE39639.1 - 0.025 14.8 0.2 0.061 13.6 0.0 1.8 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EKE39639.1 - 0.036 13.8 0.5 0.083 12.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain Torsin PF06309.11 EKE39639.1 - 0.051 13.7 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Torsin PduV-EutP PF10662.9 EKE39639.1 - 0.069 12.9 0.7 0.44 10.3 0.0 2.3 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 EKE39639.1 - 0.077 13.5 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EKE39639.1 - 0.078 13.1 1.3 0.29 11.3 0.1 2.2 2 1 1 3 3 3 0 AAA domain Hpr_kinase_C PF07475.12 EKE39639.1 - 0.083 12.4 0.4 0.21 11.1 0.0 1.7 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_7 PF12775.7 EKE39639.1 - 0.11 12.1 1.8 0.11 12.0 0.1 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region RuvB_N PF05496.12 EKE39639.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EKE39639.1 - 0.13 12.6 0.0 0.22 11.9 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain IstB_IS21 PF01695.17 EKE39639.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AIG1 PF04548.16 EKE39639.1 - 0.17 11.2 5.0 0.29 10.4 0.3 2.4 2 1 0 2 2 2 0 AIG1 family Ank_2 PF12796.7 EKE39641.1 - 4.1e-66 219.6 12.2 1e-11 45.2 0.4 7.4 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE39641.1 - 2.2e-57 190.7 22.5 1.3e-08 35.2 0.1 12.1 4 3 7 12 12 12 12 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE39641.1 - 4.8e-57 189.3 12.2 9.9e-08 32.1 0.0 11.8 5 3 8 13 13 13 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE39641.1 - 8.4e-51 164.0 12.5 0.002 18.5 0.0 13.8 13 0 0 13 13 13 12 Ankyrin repeat Ank PF00023.30 EKE39641.1 - 1.5e-37 126.4 18.9 0.0032 17.9 0.0 14.2 15 0 0 15 15 15 8 Ankyrin repeat Hexapep PF00132.24 EKE39641.1 - 1.5e-13 49.9 17.1 8e-09 34.9 3.6 3.8 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EKE39641.1 - 2.3e-10 40.1 18.2 1.4e-05 24.7 2.5 3.6 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 EKE39641.1 - 0.008 16.4 0.0 0.022 15.0 0.0 1.8 1 0 0 1 1 1 1 Maltose acetyltransferase DUF3447 PF11929.8 EKE39641.1 - 0.11 12.5 0.0 0.11 12.5 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF3447) DHHC PF01529.20 EKE39642.1 - 3.1e-21 75.9 18.3 3.1e-21 75.9 18.3 2.7 1 1 1 2 2 2 1 DHHC palmitoyltransferase RRM_1 PF00076.22 EKE39643.1 - 0.039 13.8 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mod_r PF07200.13 EKE39644.1 - 0.054 13.6 3.5 0.087 12.9 3.5 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF4999 PF16390.5 EKE39644.1 - 0.066 13.5 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function OmpH PF03938.14 EKE39644.1 - 0.28 11.5 7.8 0.38 11.1 7.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) AAA_11 PF13086.6 EKE39644.1 - 7.9 6.2 6.3 9.1 6.0 6.3 1.2 1 0 0 1 1 1 0 AAA domain Lactamase_B_3 PF13483.6 EKE39646.1 - 1e-23 84.0 0.9 1.2e-23 83.8 0.9 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EKE39646.1 - 8.4e-13 48.3 1.0 2.2e-12 46.9 1.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF787 PF05619.11 EKE39646.1 - 0.0017 17.6 0.1 0.0021 17.2 0.1 1.1 1 0 0 1 1 1 1 Borrelia burgdorferi protein of unknown function (DUF787) Macro PF01661.21 EKE39647.1 - 2.7e-31 108.0 0.3 2.7e-31 108.0 0.3 1.6 2 0 0 2 2 2 1 Macro domain zf-RING_2 PF13639.6 EKE39649.1 - 1.5e-07 31.6 9.8 1.5e-07 31.6 9.8 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKE39649.1 - 1.5e-07 31.1 8.0 1.5e-07 31.1 8.0 2.3 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EKE39649.1 - 7.8e-07 29.3 8.8 1.9e-06 28.0 8.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EKE39649.1 - 1.4e-06 28.1 8.9 1.4e-06 28.1 8.9 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EKE39649.1 - 1.9e-06 27.6 6.8 1.9e-06 27.6 6.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE39649.1 - 1.7e-05 24.6 8.4 3.6e-05 23.5 8.4 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EKE39649.1 - 5e-05 23.2 2.7 5e-05 23.2 2.7 3.4 2 1 1 3 3 3 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EKE39649.1 - 0.00024 21.1 7.0 0.00094 19.2 7.1 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EKE39649.1 - 0.00062 19.7 8.7 0.00062 19.7 8.7 2.1 2 1 0 2 2 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 EKE39649.1 - 0.026 14.2 7.7 0.026 14.2 7.7 3.3 4 0 0 4 4 4 0 RING-like zinc finger DUF1003 PF06210.11 EKE39649.1 - 0.045 13.9 3.7 0.16 12.1 3.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) zf-Nse PF11789.8 EKE39649.1 - 9.8 6.1 9.3 2.3 8.1 5.6 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Prismane PF03063.20 EKE39650.1 - 4.3e-148 494.2 1.1 4.9e-148 494.0 1.1 1.0 1 0 0 1 1 1 1 Prismane/CO dehydrogenase family Ada_Zn_binding PF02805.16 EKE39650.1 - 0.02 14.9 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 Metal binding domain of Ada PRK PF00485.18 EKE39651.1 - 3.2e-16 59.7 0.2 1.8e-15 57.2 0.0 2.3 2 1 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 EKE39651.1 - 3.1e-05 24.2 0.0 6.3e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EKE39651.1 - 0.0023 18.4 0.0 0.0082 16.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EKE39651.1 - 0.038 14.4 0.0 0.12 12.8 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Cytidylate_kin PF02224.18 EKE39651.1 - 0.04 13.6 0.1 0.08 12.7 0.1 1.5 1 0 0 1 1 1 0 Cytidylate kinase AAA_24 PF13479.6 EKE39651.1 - 0.041 13.6 0.0 0.16 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EKE39651.1 - 0.044 13.4 0.5 0.37 10.4 0.0 2.3 1 1 1 2 2 2 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EKE39651.1 - 0.052 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DivIVA PF05103.13 EKE39651.1 - 0.081 13.0 1.5 0.2 11.8 1.5 1.6 1 0 0 1 1 1 0 DivIVA protein MobB PF03205.14 EKE39651.1 - 0.099 12.5 0.1 0.33 10.9 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Peptidase_S9 PF00326.21 EKE39652.1 - 1.9e-07 30.8 0.0 6.1e-07 29.1 0.0 1.7 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EKE39652.1 - 3e-07 29.9 0.0 0.012 14.9 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EKE39652.1 - 1.2e-05 25.1 0.1 0.073 12.7 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EKE39652.1 - 0.00029 20.7 0.6 0.048 13.5 0.9 3.2 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase DLH PF01738.18 EKE39652.1 - 0.0015 18.1 0.0 0.0054 16.3 0.0 1.7 2 0 0 2 2 2 1 Dienelactone hydrolase family FSH1 PF03959.13 EKE39652.1 - 0.0018 18.0 0.0 0.0021 17.8 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) LIP PF03583.14 EKE39652.1 - 0.0024 17.2 0.1 0.056 12.8 0.0 2.0 1 1 0 2 2 2 1 Secretory lipase DUF1749 PF08538.10 EKE39652.1 - 0.0067 15.6 0.0 0.014 14.5 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) DUF1057 PF06342.12 EKE39652.1 - 0.021 13.9 0.0 0.037 13.1 0.0 1.5 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_6 PF12697.7 EKE39652.1 - 0.22 12.1 0.0 2.5 8.6 0.0 1.9 1 1 0 2 2 2 0 Alpha/beta hydrolase family UPF0061 PF02696.14 EKE39653.1 - 0.053 12.3 0.1 0.067 12.0 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family DUF5301 PF17225.3 EKE39653.1 - 0.076 13.4 0.2 0.076 13.4 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF5300) AAA PF00004.29 EKE39654.1 - 6.4e-51 172.2 0.1 7.6e-40 136.4 0.0 3.2 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKE39654.1 - 2.3e-10 40.1 0.0 5.4e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_18 PF13238.6 EKE39654.1 - 1.2e-07 32.4 0.0 0.015 15.9 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EKE39654.1 - 7.3e-07 29.7 0.1 0.02 15.3 0.0 3.4 3 1 0 3 3 3 2 AAA ATPase domain RNA_helicase PF00910.22 EKE39654.1 - 1.1e-06 28.9 0.0 0.027 14.9 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_2 PF07724.14 EKE39654.1 - 5.2e-06 26.7 0.1 6.7e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EKE39654.1 - 1.3e-05 25.4 2.6 0.029 14.7 0.8 4.3 3 1 0 3 3 3 1 AAA domain TIP49 PF06068.13 EKE39654.1 - 2.2e-05 23.8 0.1 0.035 13.3 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_5 PF07728.14 EKE39654.1 - 3e-05 24.0 0.2 0.017 15.2 0.1 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EKE39654.1 - 3.1e-05 23.6 0.3 0.18 11.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region NB-ARC PF00931.22 EKE39654.1 - 3.9e-05 22.9 0.7 0.28 10.4 0.1 3.0 3 0 0 3 3 3 2 NB-ARC domain RuvB_N PF05496.12 EKE39654.1 - 5.6e-05 22.9 0.1 0.027 14.2 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EKE39654.1 - 9.9e-05 22.3 0.1 0.2 11.6 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EKE39654.1 - 0.0001 22.1 0.1 0.34 10.6 0.1 2.7 2 1 0 2 2 2 2 IstB-like ATP binding protein Sigma54_activat PF00158.26 EKE39654.1 - 0.00012 21.9 0.1 0.27 10.9 0.1 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain ATPase_2 PF01637.18 EKE39654.1 - 0.00021 21.3 1.9 1.3 8.9 0.0 4.0 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 EKE39654.1 - 0.00028 20.2 0.2 0.48 9.6 0.0 3.2 3 0 0 3 3 3 1 KAP family P-loop domain AAA_24 PF13479.6 EKE39654.1 - 0.00029 20.6 0.0 0.1 12.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EKE39654.1 - 0.00033 20.8 0.0 0.77 9.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 EKE39654.1 - 0.00036 19.9 0.4 0.018 14.4 0.2 2.7 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.6 EKE39654.1 - 0.00056 19.5 2.6 0.87 9.1 0.0 3.5 2 1 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EKE39654.1 - 0.00078 18.9 0.5 0.0056 16.1 0.1 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EKE39654.1 - 0.0011 19.0 0.0 1.4 9.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 EKE39654.1 - 0.0012 18.3 1.8 0.21 11.0 0.5 2.4 2 0 0 2 2 2 1 PhoH-like protein NACHT PF05729.12 EKE39654.1 - 0.0015 18.4 6.5 2.5 8.0 0.0 4.7 6 0 0 6 6 4 1 NACHT domain Zeta_toxin PF06414.12 EKE39654.1 - 0.0034 16.7 1.7 0.094 12.0 0.2 2.5 2 0 0 2 2 2 1 Zeta toxin ABC_tran PF00005.27 EKE39654.1 - 0.0085 16.6 1.4 0.22 12.1 0.1 2.8 2 1 0 2 2 2 1 ABC transporter CDC48_N PF02359.18 EKE39654.1 - 0.01 16.0 0.0 0.033 14.4 0.0 1.8 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain AAA_17 PF13207.6 EKE39654.1 - 0.016 15.7 0.1 9.1 6.7 0.0 3.0 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 EKE39654.1 - 0.051 13.4 0.5 8.9 6.1 0.2 3.1 2 1 0 2 2 2 0 Bacterial dnaA protein IPT PF01745.16 EKE39654.1 - 0.052 12.9 0.2 0.48 9.8 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase AAA_11 PF13086.6 EKE39654.1 - 0.052 13.3 0.3 3 7.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain DEAD PF00270.29 EKE39654.1 - 0.059 13.1 4.1 3.1 7.5 0.2 3.8 3 2 0 4 4 3 0 DEAD/DEAH box helicase Rad17 PF03215.15 EKE39654.1 - 0.074 13.0 1.7 1.5 8.7 0.2 3.5 2 2 1 3 3 3 0 Rad17 P-loop domain T2SSE PF00437.20 EKE39654.1 - 0.078 12.0 0.1 1.7 7.7 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein ResIII PF04851.15 EKE39654.1 - 0.57 10.2 3.5 10 6.1 0.0 3.1 3 1 0 3 3 2 0 Type III restriction enzyme, res subunit RasGEF PF00617.19 EKE39655.1 - 7.1e-38 130.6 5.3 2.2e-37 129.0 5.3 1.9 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE39655.1 - 5.1e-11 42.7 6.6 1.2e-10 41.5 0.0 3.3 3 0 0 3 3 3 1 RasGEF N-terminal motif Metallophos PF00149.28 EKE39656.1 - 1.8e-36 126.6 0.0 2.2e-36 126.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE39656.1 - 8.9e-05 22.7 0.0 0.00021 21.5 0.0 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 EKE39656.1 - 0.0037 17.7 0.6 0.0037 17.7 0.6 1.9 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Lactamase_B PF00753.27 EKE39657.1 - 0.68 9.9 4.7 1.2 9.2 2.7 2.2 2 1 0 2 2 2 0 Metallo-beta-lactamase superfamily CDP-OH_P_transf PF01066.21 EKE39658.1 - 3.1e-14 53.5 0.2 3.1e-14 53.5 0.2 3.7 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase TMEM108 PF15759.5 EKE39658.1 - 0.2 10.7 0.8 0.28 10.1 0.8 1.1 1 0 0 1 1 1 0 TMEM108 family Rep_fac-A_C PF08646.10 EKE39659.1 - 4.6e-12 45.9 4.9 4.6e-12 45.9 4.9 2.3 2 0 0 2 2 2 1 Replication factor-A C terminal domain tRNA_anti-codon PF01336.25 EKE39659.1 - 8.3e-08 32.1 4.0 0.0018 18.2 0.0 4.1 4 0 0 4 4 4 2 OB-fold nucleic acid binding domain REPA_OB_2 PF16900.5 EKE39659.1 - 0.00022 21.1 2.6 0.0011 18.8 0.3 2.9 3 0 0 3 3 3 1 Replication protein A OB domain FAM35_C PF15793.5 EKE39659.1 - 0.019 14.3 0.2 0.054 12.9 0.2 1.7 1 0 0 1 1 1 0 Protein family FAM35, C-terminal AMMECR1 PF01871.17 EKE39660.1 - 2.9e-38 131.1 0.0 3.5e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 Pepsin-I3 PF06394.13 EKE39660.1 - 0.05 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Pepsin inhibitor-3-like repeated domain Myb_DNA-binding PF00249.31 EKE39660.1 - 0.18 12.0 0.2 0.18 12.0 0.2 1.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain Rhodanese PF00581.20 EKE39661.1 - 4.4e-10 40.0 0.0 7.9e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain MFS_1 PF07690.16 EKE39662.1 - 6.2e-32 110.9 26.4 9.6e-21 74.1 5.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Myc_target_1 PF15179.6 EKE39662.1 - 0.0036 17.2 0.2 0.0065 16.4 0.2 1.4 1 0 0 1 1 1 1 Myc target protein 1 DUF2681 PF10883.8 EKE39662.1 - 0.068 13.6 0.0 3.2 8.2 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF2615 PF11027.8 EKE39662.1 - 0.76 9.9 2.8 13 6.0 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF2615) VPS13_C PF16909.5 EKE39663.1 - 6.7e-53 179.1 14.8 1.2e-51 175.0 1.7 4.3 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 EKE39663.1 - 2.9e-36 125.5 20.5 3.4e-36 125.2 3.2 4.3 5 0 0 5 5 5 2 Vacuolar sorting-associated protein 13, N-terminal SHR-BD PF06650.12 EKE39663.1 - 2.8e-16 59.7 24.6 3.2e-15 56.2 1.5 4.4 4 0 0 4 4 4 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 EKE39663.1 - 8.6e-15 54.8 6.5 8.6e-15 54.8 6.5 7.3 8 1 0 8 8 8 1 Repeating coiled region of VPS13 ATG_C PF09333.11 EKE39663.1 - 7.1e-07 29.5 0.0 2.2e-06 27.9 0.0 1.9 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain bPH_3 PF14470.6 EKE39663.1 - 0.0077 16.6 1.3 0.0077 16.6 1.3 4.5 6 0 0 6 6 6 1 Bacterial PH domain RNA_pol_Rpc4 PF05132.14 EKE39663.1 - 2.8 8.3 11.2 26 5.2 0.0 3.9 3 0 0 3 3 3 0 RNA polymerase III RPC4 ENTH PF01417.20 EKE39664.1 - 0.0068 16.4 0.2 0.015 15.3 0.2 1.6 1 0 0 1 1 1 1 ENTH domain CN_hydrolase PF00795.22 EKE39665.1 - 7.4e-28 97.6 0.0 8.6e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase SH2_2 PF14633.6 EKE39665.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 SH2 domain DnaJ PF00226.31 EKE39666.1 - 3.9e-25 87.8 5.4 3.9e-25 87.8 5.4 1.8 2 0 0 2 2 2 1 DnaJ domain LRR_8 PF13855.6 EKE39666.1 - 3.3e-20 71.6 14.1 2e-10 40.2 1.4 3.0 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EKE39666.1 - 6.2e-14 51.9 4.8 2.4e-05 24.6 0.0 3.3 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EKE39666.1 - 1.5e-06 27.8 2.6 2.9e-06 26.9 2.6 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_5 PF13306.6 EKE39666.1 - 7.5e-06 25.9 9.1 3.2e-05 23.9 8.9 1.9 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EKE39666.1 - 0.0049 17.2 6.9 19 6.3 0.1 5.1 4 1 1 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 EKE39666.1 - 0.027 14.5 10.8 3.9 7.8 0.1 4.6 5 0 0 5 5 5 0 Leucine Rich repeat CotJB PF12652.7 EKE39666.1 - 0.033 14.4 1.4 0.11 12.8 0.5 2.4 2 1 0 2 2 2 0 CotJB protein EFhand_Ca_insen PF08726.10 EKE39666.1 - 0.036 14.1 0.0 1.2 9.2 0.0 2.6 2 0 0 2 2 2 0 Ca2+ insensitive EF hand Gln-synt_C PF00120.24 EKE39666.1 - 0.046 12.7 0.3 0.071 12.1 0.3 1.3 1 0 0 1 1 1 0 Glutamine synthetase, catalytic domain DUF3557 PF12078.8 EKE39666.1 - 0.069 13.1 2.3 0.2 11.6 2.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3557) DNA_pol_B PF00136.21 EKE39667.1 - 1.2e-82 278.1 1.4 1.2e-82 278.1 1.4 2.3 2 0 0 2 2 2 1 DNA polymerase family B zf-C4pol PF14260.6 EKE39667.1 - 2.4e-05 24.7 15.6 2.7e-05 24.5 12.7 2.8 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta Popeye PF04831.13 EKE39668.1 - 5.7 7.1 9.4 3.1 8.0 7.5 1.6 1 1 1 2 2 2 0 Popeye protein conserved region zf-C2H2_2 PF12756.7 EKE39669.1 - 0.0017 18.6 0.3 0.0031 17.8 0.3 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 EKE39669.1 - 0.021 15.1 0.5 0.043 14.1 0.5 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Nop PF01798.18 EKE39669.1 - 0.038 13.5 5.4 0.069 12.6 5.4 1.5 1 1 0 1 1 1 0 snoRNA binding domain, fibrillarin DUF4729 PF15866.5 EKE39669.1 - 0.099 12.0 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4729) LPD15 PF18828.1 EKE39669.1 - 0.76 9.7 5.6 0.2 11.6 2.3 1.7 2 0 0 2 2 2 0 Large polyvalent-protein-associated domain 15 SKICH PF17751.1 EKE39670.1 - 1.7e-08 34.9 4.1 2.9e-05 24.5 0.0 3.2 2 2 1 3 3 3 2 SKICH domain Rad60-SLD PF11976.8 EKE39670.1 - 0.13 12.1 0.0 1 9.3 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like RhoGEF PF00621.20 EKE39671.1 - 2.9e-42 145.0 11.0 3.6e-42 144.7 9.0 2.2 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 EKE39671.1 - 1.9e-15 56.7 11.6 1.9e-15 56.7 11.6 1.9 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.16 EKE39671.1 - 0.00046 20.4 9.1 0.0013 18.9 9.1 1.8 1 0 0 1 1 1 1 FYVE-type zinc finger PH PF00169.29 EKE39671.1 - 0.00097 19.6 1.0 0.00097 19.6 1.0 2.9 3 0 0 3 3 3 1 PH domain PH_3 PF14593.6 EKE39671.1 - 0.013 15.6 0.5 0.049 13.7 0.5 2.0 1 0 0 1 1 1 0 PH domain Patatin PF01734.22 EKE39672.1 - 2.1e-19 70.5 0.0 6.9e-19 68.8 0.0 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase Ank_2 PF12796.7 EKE39672.1 - 2.9e-12 47.0 0.7 0.00015 22.2 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE39672.1 - 7.6e-08 32.8 0.0 0.13 12.9 0.0 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE39672.1 - 4.9e-06 26.5 0.0 3.7 8.4 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EKE39672.1 - 0.0012 19.1 0.0 1.7 9.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EKE39672.1 - 0.0013 19.1 0.0 0.63 10.6 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat BCNT PF07572.12 EKE39672.1 - 4.2 7.5 7.6 7.7 6.7 3.6 2.4 2 0 0 2 2 2 0 Bucentaur or craniofacial development Pkinase PF00069.25 EKE39673.1 - 9.2e-60 202.2 0.0 1.2e-59 201.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39673.1 - 1.8e-29 102.9 0.0 2.5e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE39673.1 - 0.00071 19.0 0.5 0.0053 16.1 0.1 2.3 2 1 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 EKE39673.1 - 0.12 11.2 0.1 0.18 10.6 0.1 1.2 1 0 0 1 1 1 0 Fungal protein kinase FERM_M PF00373.18 EKE39674.1 - 6.2e-09 36.3 0.3 1.7e-08 34.9 0.1 1.8 2 0 0 2 2 2 1 FERM central domain LRR_4 PF12799.7 EKE39674.1 - 0.00017 21.9 24.2 0.037 14.5 0.8 7.9 6 2 4 10 10 10 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EKE39674.1 - 0.0098 16.3 10.3 13 6.8 0.3 6.9 7 0 0 7 7 7 1 Leucine Rich Repeat DUF3802 PF12290.8 EKE39674.1 - 0.035 14.6 0.1 0.14 12.7 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) Rad60-SLD PF11976.8 EKE39674.1 - 0.11 12.4 1.8 0.88 9.5 0.1 2.9 3 0 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like FERM_N PF09379.10 EKE39674.1 - 0.15 12.0 0.2 0.49 10.4 0.2 1.9 1 0 0 1 1 1 0 FERM N-terminal domain LRR_6 PF13516.6 EKE39674.1 - 0.64 10.2 30.0 6.5 7.1 0.0 9.4 11 0 0 11 11 11 0 Leucine Rich repeat LRR_8 PF13855.6 EKE39674.1 - 2.4 8.0 18.6 0.66 9.8 0.4 5.8 6 1 0 6 6 6 0 Leucine rich repeat Ras PF00071.22 EKE39675.1 - 2.1e-09 37.2 0.2 2.7e-09 36.8 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39675.1 - 1.7e-07 31.5 0.1 2.8e-07 30.7 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39675.1 - 0.0004 19.9 0.1 0.00055 19.4 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_pol_A_bac PF01000.26 EKE39676.1 - 2.2e-20 73.1 0.1 1.5e-18 67.2 0.0 2.6 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EKE39676.1 - 2.2e-16 59.0 0.0 2.9e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_9 PF13187.6 EKE39676.1 - 0.0012 18.9 2.7 0.0029 17.7 2.7 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain ETF_QO PF05187.13 EKE39676.1 - 0.042 14.0 1.2 0.093 12.9 1.2 1.6 1 0 0 1 1 1 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S PP2C PF00481.21 EKE39677.1 - 3.1e-52 177.8 0.0 4e-52 177.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EKE39677.1 - 1.7e-30 104.5 69.7 5.8e-08 32.4 6.2 9.8 3 3 5 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 EKE39677.1 - 2.2e-28 97.8 84.1 2.3e-05 24.6 2.6 11.9 7 3 5 12 12 12 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EKE39677.1 - 0.0093 15.5 3.9 0.0093 15.5 3.9 5.5 1 1 5 6 6 6 3 Leucine-rich repeat LRR_1 PF00560.33 EKE39677.1 - 0.024 15.1 70.0 0.8 10.5 0.2 15.9 16 1 0 16 16 16 0 Leucine Rich Repeat Choline_transpo PF04515.12 EKE39679.1 - 3.8e-60 203.8 41.8 5.2e-60 203.4 33.9 2.3 2 1 0 2 2 2 2 Plasma-membrane choline transporter RasGAP PF00616.19 EKE39680.1 - 6.4e-32 111.0 9.3 7.8e-24 84.5 0.1 3.3 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 EKE39680.1 - 0.00039 20.6 0.4 0.0013 18.9 0.4 1.9 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain MAGE PF01454.19 EKE39680.1 - 0.045 13.4 0.4 0.15 11.7 0.4 1.8 1 1 0 1 1 1 0 MAGE family BLOC1_2 PF10046.9 EKE39680.1 - 2.1 8.7 5.7 5.3 7.4 1.4 2.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Pox_MCEL PF03291.16 EKE39681.1 - 3.2e-65 220.4 8.5 7.4e-64 215.9 8.5 2.0 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EKE39681.1 - 6.8e-10 39.5 0.0 1.1e-09 38.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKE39681.1 - 3.5e-06 27.6 0.0 6.7e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EKE39681.1 - 5.7e-06 27.0 0.0 9.5e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EKE39681.1 - 0.00074 18.8 0.0 0.0012 18.0 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Ubie_methyltran PF01209.18 EKE39681.1 - 0.0013 18.2 0.0 0.0022 17.3 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EKE39681.1 - 0.0038 17.1 0.0 0.0053 16.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EKE39681.1 - 0.0059 16.2 0.0 0.012 15.2 0.0 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase SF3A3 PF16837.5 EKE39681.1 - 2.2 8.9 6.8 1.6 9.3 0.6 3.0 4 0 0 4 4 4 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 RPN13_C PF16550.5 EKE39682.1 - 1.3e-07 31.8 0.0 2.2e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 UCH-binding domain Proteasom_Rpn13 PF04683.13 EKE39682.1 - 3.1e-05 24.4 0.7 8.1e-05 23.1 0.3 1.9 2 0 0 2 2 2 1 Proteasome complex subunit Rpn13 ubiquitin receptor DUF2073 PF09846.9 EKE39682.1 - 0.096 12.6 1.3 7.7 6.4 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2073) Peptidase_S10 PF00450.22 EKE39682.1 - 0.12 11.8 0.0 0.64 9.4 0.0 1.9 2 0 0 2 2 2 0 Serine carboxypeptidase Hexapep PF00132.24 EKE39684.1 - 2.3e-10 39.7 7.9 4.2e-07 29.4 1.9 2.5 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) SATase_N PF06426.14 EKE39684.1 - 0.0022 18.3 0.0 0.0043 17.4 0.0 1.5 1 0 0 1 1 1 1 Serine acetyltransferase, N-terminal Hexapep_2 PF14602.6 EKE39684.1 - 0.04 13.7 0.8 0.04 13.7 0.8 3.0 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase Thioredoxin PF00085.20 EKE39685.1 - 4.2e-31 107.0 0.0 4.8e-22 77.9 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_2 PF13098.6 EKE39685.1 - 2.8e-10 40.6 0.1 0.00047 20.6 0.0 3.6 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EKE39685.1 - 1.4e-06 28.5 0.2 3.3 8.1 0.0 4.3 3 1 1 4 4 4 3 Thioredoxin-like Thioredoxin_3 PF13192.6 EKE39685.1 - 2.1e-06 27.7 0.0 0.1 12.7 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin domain Thioredoxin_6 PF13848.6 EKE39685.1 - 2.5e-06 27.5 0.1 1.6 8.6 0.1 3.5 3 1 1 4 4 4 4 Thioredoxin-like domain OST3_OST6 PF04756.13 EKE39685.1 - 3.6e-05 23.3 0.0 8.5e-05 22.0 0.0 1.6 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family TraF PF13728.6 EKE39685.1 - 6.5e-05 22.9 0.0 0.15 11.8 0.0 2.4 2 0 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 EKE39685.1 - 9.8e-05 22.5 0.0 0.0006 19.9 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EKE39685.1 - 0.0044 16.8 0.0 0.014 15.2 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin AhpC-TSA PF00578.21 EKE39685.1 - 0.011 15.7 0.1 0.052 13.5 0.0 2.2 2 0 0 2 2 2 0 AhpC/TSA family Dmrt1 PF12374.8 EKE39686.1 - 0.079 13.4 0.8 0.11 12.9 0.8 1.2 1 0 0 1 1 1 0 Double-sex mab3 related transcription factor 1 ubiquitin PF00240.23 EKE39687.1 - 5.2e-15 54.9 5.1 1.5e-14 53.5 5.1 1.8 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKE39687.1 - 1.6e-05 24.6 2.6 1.6e-05 24.6 2.6 2.2 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EKE39687.1 - 3.2e-05 23.9 5.7 0.065 13.3 0.1 3.1 2 1 1 3 3 3 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EKE39687.1 - 0.00018 21.8 4.6 0.00018 21.8 4.6 2.6 2 1 1 3 3 3 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EKE39687.1 - 0.00024 21.2 2.4 0.00088 19.4 2.4 2.0 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EKE39687.1 - 0.0084 16.7 1.4 0.0084 16.7 1.4 2.0 2 2 0 2 2 2 1 DUF2407 ubiquitin-like domain Ubiquitin_2 PF14560.6 EKE39687.1 - 0.025 15.0 3.8 0.036 14.5 2.5 2.0 2 0 0 2 2 2 0 Ubiquitin-like domain XPC-binding PF09280.11 EKE39687.1 - 0.032 14.0 0.2 0.032 14.0 0.2 1.9 2 0 0 2 2 2 0 XPC-binding domain T3SS_basalb_I PF17001.5 EKE39687.1 - 0.039 14.5 0.4 0.24 12.0 0.0 2.4 2 1 0 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI PB1 PF00564.24 EKE39687.1 - 0.095 12.6 1.6 1.8 8.6 0.1 3.2 2 2 1 3 3 3 0 PB1 domain hSH3 PF14603.6 EKE39687.1 - 0.44 11.0 5.7 0.24 11.9 1.6 2.3 2 0 0 2 2 2 0 Helically-extended SH3 domain Sre PF03125.18 EKE39688.1 - 1.4 7.9 18.3 4.9 6.2 18.3 1.7 1 1 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor RhoGAP PF00620.27 EKE39689.1 - 4.5e-40 136.9 0.0 8.7e-40 136.0 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain Histone_HNS PF00816.21 EKE39689.1 - 0.13 13.1 0.0 0.35 11.7 0.0 1.7 1 0 0 1 1 1 0 H-NS histone family Phage_pRha PF09669.10 EKE39689.1 - 0.17 12.5 2.2 0.31 11.6 0.5 2.3 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) Avl9 PF09794.9 EKE39690.1 - 1.7e-11 43.5 6.5 1e-08 34.3 0.1 2.7 1 1 1 2 2 2 2 Transport protein Avl9 SPA PF08616.10 EKE39690.1 - 1.1e-06 28.5 0.1 4.2e-06 26.7 0.1 2.0 1 0 0 1 1 1 1 Stabilization of polarity axis DUF2347 PF09804.9 EKE39690.1 - 0.0043 16.7 0.4 0.0043 16.7 0.4 2.3 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) DUF4050 PF13259.6 EKE39690.1 - 0.033 14.5 3.1 0.056 13.8 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Zip PF02535.22 EKE39690.1 - 1.3 8.2 4.2 2.4 7.3 4.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter NRBF2 PF08961.10 EKE39691.1 - 0.0011 18.6 1.1 0.0011 18.6 1.1 1.6 2 0 0 2 2 2 1 Nuclear receptor-binding factor 2, autophagy regulator NUDE_C PF04880.13 EKE39691.1 - 0.002 18.6 12.1 0.0027 18.2 12.1 1.2 1 0 0 1 1 1 1 NUDE protein, C-terminal conserved region CAF-1_p150 PF11600.8 EKE39691.1 - 0.0028 17.4 11.9 0.0028 17.4 11.9 1.9 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF2381 PF09544.10 EKE39691.1 - 0.01 15.4 2.5 0.01 15.4 2.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2381) Borrelia_P83 PF05262.11 EKE39691.1 - 0.015 13.9 1.0 0.012 14.1 1.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein ZapB PF06005.12 EKE39691.1 - 0.019 15.4 12.9 0.044 14.2 12.9 1.5 1 0 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.15 EKE39691.1 - 0.032 14.0 9.0 0.032 14.0 9.0 1.9 2 1 0 2 2 2 0 Septum formation initiator UL42 PF17638.2 EKE39691.1 - 0.056 13.4 3.5 0.075 13.0 3.5 1.2 1 0 0 1 1 1 0 HCMV UL42 CAP_N PF01213.19 EKE39691.1 - 0.072 12.6 5.4 0.091 12.2 5.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 EKE39691.1 - 0.11 12.5 6.0 0.17 11.9 6.0 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-C4H2 PF10146.9 EKE39691.1 - 0.14 12.5 7.0 0.084 13.2 5.5 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein QWRF PF04484.12 EKE39691.1 - 0.18 11.5 4.0 0.23 11.2 4.0 1.1 1 0 0 1 1 1 0 QWRF family TLE_N PF03920.15 EKE39691.1 - 0.23 11.5 4.2 0.4 10.8 4.2 1.4 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain HALZ PF02183.18 EKE39691.1 - 0.28 11.4 8.8 0.36 11.1 1.3 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper Rrn6 PF10214.9 EKE39691.1 - 0.45 8.9 7.6 0.36 9.3 6.8 1.2 1 1 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor YabA PF06156.13 EKE39691.1 - 0.54 10.9 7.5 0.11 13.2 4.2 1.5 2 0 0 2 2 2 0 Initiation control protein YabA Ufd2P_core PF10408.9 EKE39691.1 - 0.77 8.3 2.4 1 7.9 2.4 1.1 1 0 0 1 1 1 0 Ubiquitin elongating factor core ERM PF00769.19 EKE39691.1 - 1.5 8.5 19.7 3.2 7.5 19.7 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family UPF0242 PF06785.11 EKE39691.1 - 2.6 8.1 12.4 0.39 10.8 8.3 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Radial_spoke_3 PF06098.11 EKE39691.1 - 2.8 7.1 13.2 1.2 8.4 10.9 1.5 2 0 0 2 2 2 0 Radial spoke protein 3 DUF3824 PF12868.7 EKE39691.1 - 3.2 8.4 9.5 2.6 8.7 7.8 1.7 1 1 1 2 2 2 0 Domain of unknwon function (DUF3824) MctB PF11382.8 EKE39691.1 - 5.8 6.5 6.9 1.5 8.5 3.9 1.5 2 0 0 2 2 2 0 Copper transport outer membrane protein, MctB Spc24 PF08286.11 EKE39691.1 - 6.4 7.1 10.3 1.7 8.9 6.1 1.9 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 G-gamma PF00631.22 EKE39691.1 - 7.1 6.7 12.1 4.5 7.4 4.2 2.5 1 1 1 2 2 2 0 GGL domain Ras PF00071.22 EKE39692.1 - 2.6e-53 179.9 0.6 3.2e-53 179.7 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39692.1 - 7.7e-18 64.9 0.0 1.3e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39692.1 - 3.6e-11 42.8 0.1 4.3e-11 42.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE39692.1 - 1.2e-06 28.2 0.1 1.7e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE39692.1 - 0.0023 17.9 3.1 0.0084 16.0 0.2 2.2 1 1 1 2 2 2 1 RsgA GTPase Syntaxin-18_N PF10496.9 EKE39692.1 - 0.02 15.2 0.5 0.062 13.6 0.6 1.7 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus AlaDh_PNT_C PF01262.21 EKE39692.1 - 0.12 11.6 0.2 0.14 11.4 0.1 1.3 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HECT PF00632.25 EKE39693.1 - 1e-67 228.8 2.1 2.5e-67 227.5 2.1 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 EKE39693.1 - 0.0044 16.7 0.1 0.012 15.4 0.1 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Nuc_sug_transp PF04142.15 EKE39695.1 - 1.2e-63 215.2 25.6 1.5e-63 214.8 25.6 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EKE39695.1 - 0.00012 22.3 34.0 0.022 15.0 12.2 2.5 2 1 0 2 2 2 2 EamA-like transporter family Rap_GAP PF02145.15 EKE39696.1 - 9.5e-59 198.1 0.0 2.1e-58 196.9 0.0 1.6 1 0 0 1 1 1 1 Rap/ran-GAP Sulfotransfer_3 PF13469.6 EKE39697.1 - 3.8e-22 79.7 0.1 1.1e-21 78.2 0.0 1.8 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EKE39697.1 - 0.00074 19.1 0.1 0.2 11.1 0.0 2.5 2 0 0 2 2 2 2 Sulfotransferase domain Methyltransf_11 PF08241.12 EKE39698.1 - 9.6e-12 45.4 0.0 3.7e-11 43.5 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE39698.1 - 1.7e-07 31.8 0.3 1.9e-06 28.5 0.0 2.7 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKE39698.1 - 5e-05 23.2 0.0 9.6e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF948 PF06103.11 EKE39698.1 - 5.8 7.2 10.8 30 5.0 6.0 3.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF745 PF05335.13 EKE39698.1 - 8.3 6.1 21.9 1.5 8.5 16.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) GPI2 PF06432.11 EKE39699.1 - 7.4e-56 189.7 16.9 9.2e-56 189.3 16.9 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Deltameth_res PF16020.5 EKE39699.1 - 0.028 14.3 5.6 3.2 7.7 0.1 3.5 3 0 0 3 3 3 0 Deltamethrin resistance PUF PF00806.19 EKE39700.1 - 1.2e-27 94.0 3.7 6.4e-08 31.9 0.0 4.6 5 0 0 5 5 5 4 Pumilio-family RNA binding repeat Smr PF01713.21 EKE39701.1 - 0.0038 17.6 1.2 0.0057 17.0 0.1 1.8 2 0 0 2 2 2 1 Smr domain Ndc1_Nup PF09531.10 EKE39701.1 - 1.7 7.2 3.7 1.6 7.3 3.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NLRC4_HD PF17889.1 EKE39702.1 - 0.0076 16.6 4.5 7.3 7.0 0.3 4.8 3 1 0 3 3 3 2 NLRC4 helical domain Symplekin_C PF12295.8 EKE39702.1 - 0.066 13.3 5.1 0.081 13.0 0.0 3.8 4 0 0 4 4 4 0 Symplekin tight junction protein C terminal Alkyl_sulf_dimr PF14863.6 EKE39703.1 - 6.3e-56 188.7 0.1 1.1e-55 187.9 0.1 1.4 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Alkyl_sulf_C PF14864.6 EKE39703.1 - 4.6e-28 98.0 0.0 1e-27 96.9 0.0 1.6 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Lactamase_B PF00753.27 EKE39703.1 - 3.6e-23 82.6 0.1 4.3e-21 75.8 0.1 2.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EKE39703.1 - 1.3e-06 28.0 0.0 2.4e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain ANAPC3 PF12895.7 EKE39703.1 - 0.0072 16.5 0.1 0.016 15.4 0.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 SCP2 PF02036.17 EKE39703.1 - 0.0072 16.8 0.0 0.017 15.6 0.0 1.6 1 0 0 1 1 1 1 SCP-2 sterol transfer family TPR_19 PF14559.6 EKE39703.1 - 0.061 13.8 0.1 0.12 12.9 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat NatB_MDM20 PF09797.9 EKE39703.1 - 0.1 11.5 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit CBM_20 PF00686.19 EKE39705.1 - 1.4e-09 37.7 0.0 3.3e-09 36.5 0.0 1.6 1 1 0 1 1 1 1 Starch binding domain AMPK1_CBM PF16561.5 EKE39705.1 - 0.045 14.0 0.1 0.078 13.2 0.1 1.4 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase NPV_P10 PF05531.12 EKE39706.1 - 2.5e-05 24.7 9.2 0.0026 18.2 4.5 3.4 2 2 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Tropomyosin PF00261.20 EKE39706.1 - 0.00016 21.1 2.4 0.00016 21.1 2.4 2.4 2 1 0 2 2 1 1 Tropomyosin SNARE PF05739.19 EKE39706.1 - 0.0011 18.9 1.5 0.004 17.1 1.5 2.1 1 1 0 1 1 1 1 SNARE domain Snapin_Pallidin PF14712.6 EKE39706.1 - 0.0023 18.3 0.4 0.0023 18.3 0.4 2.9 2 1 0 3 3 3 1 Snapin/Pallidin V-SNARE_C PF12352.8 EKE39706.1 - 0.032 14.5 0.0 0.11 12.8 0.0 2.0 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus DUF16 PF01519.16 EKE39706.1 - 0.032 14.7 1.6 0.032 14.7 1.6 2.8 2 1 0 2 2 2 0 Protein of unknown function DUF16 UPF0184 PF03670.13 EKE39706.1 - 0.041 14.3 1.0 0.17 12.3 0.3 2.2 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0184) Serine_rich PF08824.10 EKE39706.1 - 0.12 12.3 5.7 0.81 9.7 1.0 2.2 1 1 0 2 2 2 0 Serine rich protein interaction domain KH_5 PF13184.6 EKE39706.1 - 0.13 12.4 6.7 1 9.5 2.7 2.5 2 0 0 2 2 2 0 NusA-like KH domain DUF4559 PF15112.6 EKE39706.1 - 0.8 9.3 14.7 1.6 8.3 5.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) TMPIT PF07851.13 EKE39706.1 - 0.82 8.8 6.5 1.5 8.0 0.0 2.3 2 0 0 2 2 2 0 TMPIT-like protein HAUS-augmin3 PF14932.6 EKE39706.1 - 0.85 9.2 7.2 0.52 9.8 1.8 2.4 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 DUF1947 PF09183.10 EKE39706.1 - 1.1 9.6 6.3 11 6.4 1.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) Synaptobrevin PF00957.21 EKE39706.1 - 1.5 8.6 8.1 11 5.9 8.1 2.4 1 1 0 1 1 1 0 Synaptobrevin Syntaxin_2 PF14523.6 EKE39706.1 - 1.8 9.0 8.2 3.8 7.9 0.1 2.8 2 1 1 3 3 3 0 Syntaxin-like protein WASH-7_mid PF14744.6 EKE39707.1 - 5.4e-102 341.4 16.2 5.4e-102 341.4 16.2 2.1 2 0 0 2 2 2 1 WASH complex subunit 7 WASH-7_C PF14746.6 EKE39707.1 - 2.2e-40 138.2 4.2 2.2e-40 138.2 4.2 2.2 2 0 0 2 2 2 1 WASH complex subunit 7, C-terminal zf-LYAR PF08790.11 EKE39708.1 - 1.1e-09 38.1 6.3 1.1e-09 38.1 6.3 3.0 3 0 0 3 3 3 1 LYAR-type C2HC zinc finger zf_UBZ PF18439.1 EKE39708.1 - 3.8e-05 23.2 2.3 0.062 12.9 0.1 2.7 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 EKE39708.1 - 0.5 10.9 9.5 2.7 8.6 3.0 2.7 1 1 1 2 2 2 0 Zinc finger, C2H2 type SRP-alpha_N PF04086.13 EKE39708.1 - 1.3 8.9 58.4 1.9 8.3 58.4 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Aa_trans PF01490.18 EKE39709.1 - 9.4e-18 64.1 36.0 1.5e-17 63.5 36.0 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 EKE39709.1 - 2e-08 33.5 43.9 2e-08 33.5 43.9 2.1 2 0 0 2 2 2 2 Amino acid permease DUF3687 PF12459.8 EKE39709.1 - 0.054 13.0 4.6 0.93 9.1 0.3 2.6 2 0 0 2 2 2 0 D-Ala-teichoic acid biosynthesis protein Rcd1 PF04078.13 EKE39710.1 - 2.5e-76 256.4 4.6 2.9e-76 256.2 4.6 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Ly-6_related PF06579.12 EKE39710.1 - 0.049 13.9 0.0 0.097 12.9 0.0 1.4 1 0 0 1 1 1 0 Caenorhabditis elegans ly-6-related protein Ras PF00071.22 EKE39711.1 - 1.1e-48 164.9 0.1 1.4e-48 164.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39711.1 - 1.9e-21 76.5 0.0 3.1e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39711.1 - 9.1e-11 41.5 0.0 1.3e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE39711.1 - 0.0035 16.8 0.2 0.0089 15.5 0.0 1.7 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EKE39711.1 - 0.0036 17.4 0.0 0.0061 16.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE39711.1 - 0.0052 16.4 1.7 0.12 11.9 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EKE39711.1 - 0.026 14.3 0.7 6.8 6.4 0.0 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation LIDHydrolase PF10230.9 EKE39712.1 - 1.3e-31 110.2 0.6 1.5e-31 109.9 0.6 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EKE39712.1 - 0.015 14.6 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Proton_antipo_C PF01010.19 EKE39712.1 - 0.042 13.5 0.2 0.063 12.9 0.2 1.3 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus DUF5036 PF16439.5 EKE39712.1 - 0.18 11.5 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5036) Maf PF02545.14 EKE39713.1 - 2.5e-49 167.3 0.0 2.9e-49 167.1 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein Dynein_AAA_lid PF17852.1 EKE39714.1 - 0.041 14.0 3.8 0.055 13.6 0.2 2.5 2 0 0 2 2 2 0 Dynein heavy chain AAA lid domain Ribosomal_L36 PF00444.18 EKE39714.1 - 0.1 12.8 0.7 0.27 11.5 0.7 1.7 1 0 0 1 1 1 0 Ribosomal protein L36 CSTF2_hinge PF14327.6 EKE39714.1 - 0.22 12.0 3.5 0.4 11.2 0.6 2.8 2 1 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 Phosphorylase PF00343.20 EKE39715.1 - 7.4e-06 24.5 0.1 1.1e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Carbohydrate phosphorylase Utp14 PF04615.13 EKE39716.1 - 3.9e-96 323.4 95.7 5e-96 323.0 95.7 1.0 1 0 0 1 1 1 1 Utp14 protein RuBisCO_small PF00101.20 EKE39716.1 - 0.32 11.0 3.7 0.26 11.3 0.8 2.4 2 0 0 2 2 2 0 Ribulose bisphosphate carboxylase, small chain EXS PF03124.14 EKE39717.1 - 1.6e-67 228.2 27.1 2.3e-67 227.7 27.1 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EKE39717.1 - 2.7e-26 93.4 16.5 1.9e-15 57.7 14.1 2.2 1 1 1 2 2 2 2 SPX domain Rer1 PF03248.13 EKE39719.1 - 2.9e-53 180.1 14.4 3.8e-53 179.7 14.4 1.1 1 0 0 1 1 1 1 Rer1 family DUF2208 PF09973.9 EKE39719.1 - 0.015 14.9 11.7 0.017 14.7 1.2 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) Peptidase_M3 PF01432.20 EKE39719.1 - 0.18 11.0 1.1 0.23 10.7 1.1 1.1 1 0 0 1 1 1 0 Peptidase family M3 Oxidored_q3 PF00499.20 EKE39719.1 - 0.19 11.5 5.2 0.51 10.0 5.2 1.7 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 CbiQ PF02361.16 EKE39719.1 - 3.6 7.1 8.8 0.27 10.8 2.3 1.9 1 1 1 2 2 2 0 Cobalt transport protein AmiS_UreI PF02293.15 EKE39720.1 - 0.019 15.0 0.1 0.035 14.1 0.1 1.3 1 0 0 1 1 1 0 AmiS/UreI family transporter JAB PF01398.21 EKE39720.1 - 0.11 12.5 0.1 0.4 10.7 0.0 1.8 1 1 1 2 2 2 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Peptidase_C1 PF00112.23 EKE39721.1 - 1.2e-58 198.7 0.5 1.7e-58 198.3 0.5 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE39721.1 - 5e-13 49.3 1.0 1.4e-12 47.9 1.0 1.8 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) L_protein_N PF15518.6 EKE39721.1 - 0.021 14.6 0.3 0.06 13.2 0.3 1.7 1 0 0 1 1 1 0 L protein N-terminus YL1 PF05764.13 EKE39721.1 - 0.41 10.7 6.9 0.57 10.3 6.9 1.1 1 0 0 1 1 1 0 YL1 nuclear protein His_Phos_1 PF00300.22 EKE39723.1 - 2.3e-47 161.2 0.0 2.6e-47 161.1 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SpoU_methylas_C PF12105.8 EKE39723.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 SpoU, rRNA methylase, C-terminal PH PF00169.29 EKE39724.1 - 0.011 16.3 2.7 0.036 14.6 2.6 2.0 1 1 0 1 1 1 0 PH domain PH_11 PF15413.6 EKE39724.1 - 0.021 15.2 4.0 0.066 13.6 4.0 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain Ras PF00071.22 EKE39725.1 - 6.3e-51 172.2 1.3 7.2e-51 172.0 1.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39725.1 - 2.8e-22 79.2 0.2 4.9e-22 78.4 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39725.1 - 1.2e-13 50.9 0.1 1.5e-13 50.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE39725.1 - 9.6e-06 25.6 0.1 0.00064 19.7 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EKE39725.1 - 2.6e-05 23.9 0.3 6.5e-05 22.6 0.3 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EKE39725.1 - 9.1e-05 22.0 0.2 0.0078 15.7 0.1 2.0 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EKE39725.1 - 0.00028 21.0 0.3 0.00058 19.9 0.2 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKE39725.1 - 0.0042 16.6 0.4 0.014 15.0 0.4 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EKE39725.1 - 0.0056 16.7 0.1 0.009 16.0 0.1 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain PduV-EutP PF10662.9 EKE39725.1 - 0.025 14.3 0.5 0.21 11.4 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation VD10_N PF08476.10 EKE39726.1 - 0.075 12.7 0.3 0.18 11.5 0.3 1.7 1 0 0 1 1 1 0 Viral D10 N-terminal DUF4828 PF16110.5 EKE39726.1 - 0.088 13.3 0.1 3.4 8.2 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4828) PqqD PF05402.12 EKE39726.1 - 0.097 13.0 0.0 18 5.7 0.0 3.2 3 1 0 3 3 3 0 Coenzyme PQQ synthesis protein D (PqqD) Ribonuclease_T2 PF00445.18 EKE39727.1 - 4.4e-18 66.1 1.8 6.1e-18 65.7 1.8 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family Fucokinase PF07959.12 EKE39727.1 - 0.015 14.3 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 L-fucokinase DUF16 PF01519.16 EKE39728.1 - 0.018 15.5 3.0 0.018 15.5 3.0 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 SlyX PF04102.12 EKE39728.1 - 0.03 14.9 2.2 0.03 14.9 2.2 2.1 2 1 0 2 2 2 0 SlyX YvrJ PF12841.7 EKE39728.1 - 0.17 11.5 1.4 0.39 10.3 1.4 1.7 1 0 0 1 1 1 0 YvrJ protein family DUF4407 PF14362.6 EKE39728.1 - 0.35 10.2 14.6 4.8 6.4 14.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FAM76 PF16046.5 EKE39728.1 - 0.76 9.1 11.9 1.1 8.5 11.9 1.2 1 0 0 1 1 1 0 FAM76 protein Fib_alpha PF08702.10 EKE39728.1 - 3.1 8.0 15.6 13 5.9 15.6 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family LptF_LptG PF03739.14 EKE39728.1 - 4.5 6.0 6.3 79 1.9 6.3 2.0 1 1 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Peptidase_C1 PF00112.23 EKE39729.1 - 0.0071 16.5 1.2 0.016 15.3 0.8 1.8 2 0 0 2 2 2 1 Papain family cysteine protease AWS PF17907.1 EKE39729.1 - 0.038 14.0 0.1 0.088 12.9 0.1 1.7 1 0 0 1 1 1 0 AWS domain Sep15_SelM PF08806.11 EKE39730.1 - 0.0013 18.9 0.1 0.0021 18.2 0.1 1.4 1 0 0 1 1 1 1 Sep15/SelM redox domain Pkinase PF00069.25 EKE39731.1 - 3e-49 167.8 0.1 6e-49 166.8 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39731.1 - 6.2e-45 153.5 0.0 1.1e-44 152.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE39731.1 - 5.3e-07 28.7 0.1 9.5e-07 27.9 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase TLD PF07534.16 EKE39735.1 - 0.00021 21.5 1.3 0.00057 20.1 0.9 1.9 2 0 0 2 2 2 1 TLD VATC PF18716.1 EKE39735.1 - 0.024 14.5 1.1 7.7 6.5 0.1 2.6 3 0 0 3 3 3 0 Vms1-associating treble clef domain F-box-like PF12937.7 EKE39736.1 - 3.9e-11 42.7 1.5 9.1e-11 41.5 1.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EKE39736.1 - 1.3e-08 34.5 1.5 3.1e-08 33.3 1.5 1.6 1 0 0 1 1 1 1 F-box domain PNTB PF02233.16 EKE39737.1 - 1.1e-66 225.7 5.0 1.2e-66 225.6 5.0 1.0 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit TPP_enzyme_M PF00205.22 EKE39737.1 - 0.032 14.0 0.2 0.063 13.0 0.2 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain RhoGEF PF00621.20 EKE39739.1 - 3.3e-40 138.3 4.3 5.1e-40 137.6 3.5 1.7 1 1 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 EKE39739.1 - 4.8e-20 71.5 9.8 9.6e-20 70.5 9.8 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EKE39739.1 - 1.4e-08 35.1 0.8 2.5e-08 34.4 0.1 1.8 2 0 0 2 2 2 1 PH domain FYVE_2 PF02318.16 EKE39739.1 - 0.00057 20.1 4.7 0.00057 20.1 4.7 2.4 3 0 0 3 3 3 1 FYVE-type zinc finger PH_13 PF16652.5 EKE39739.1 - 0.00062 19.6 0.3 0.093 12.5 0.3 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Se-cys_synth_N PF12390.8 EKE39739.1 - 0.035 14.3 0.0 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 Selenocysteine synthase N terminal HMG_box_5 PF14887.6 EKE39739.1 - 0.045 13.7 1.2 1.9 8.5 0.1 2.4 2 0 0 2 2 2 0 HMG (high mobility group) box 5 IQ_SEC7_PH PF16453.5 EKE39739.1 - 0.061 13.3 0.6 0.16 11.9 0.6 1.7 1 0 0 1 1 1 0 PH domain DUF3106 PF11304.8 EKE39739.1 - 0.073 13.6 0.0 19 5.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) DZR PF12773.7 EKE39739.1 - 0.19 11.7 7.8 0.95 9.5 7.8 2.2 1 1 0 1 1 1 0 Double zinc ribbon Toxin-deaminase PF14424.6 EKE39739.1 - 0.42 10.7 5.2 0.39 10.8 0.2 2.4 2 0 0 2 2 2 0 The BURPS668_1122 family of deaminases DNA_RNApol_7kD PF03604.13 EKE39739.1 - 7.9 6.3 13.1 2.4 7.9 2.4 2.7 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Ras PF00071.22 EKE39741.1 - 5.6e-56 188.6 0.9 6.4e-56 188.4 0.9 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39741.1 - 3.7e-33 114.3 0.1 6.6e-33 113.5 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39741.1 - 5.5e-12 45.5 0.3 7.2e-12 45.1 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE39741.1 - 1.9e-07 30.8 0.4 1.9e-06 27.6 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE39741.1 - 7.6e-05 22.8 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE39741.1 - 0.00024 20.6 0.0 0.00044 19.7 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EKE39741.1 - 0.005 16.2 0.2 0.0072 15.7 0.2 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EKE39741.1 - 0.011 15.2 0.0 0.02 14.4 0.0 1.5 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 EKE39741.1 - 0.084 12.6 0.4 0.44 10.3 0.1 2.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TMIE PF16038.5 EKE39742.1 - 0.0039 17.0 1.6 0.0078 16.0 1.6 1.5 1 0 0 1 1 1 1 TMIE protein FERM_N PF09379.10 EKE39742.1 - 0.068 13.1 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 FERM N-terminal domain ETRAMP PF09716.10 EKE39742.1 - 0.33 11.0 5.3 0.66 10.1 5.3 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) RhoGAP PF00620.27 EKE39744.1 - 4.3e-23 81.8 0.4 9.5e-23 80.7 0.4 1.6 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EKE39744.1 - 0.0047 17.4 1.0 0.014 15.9 0.0 2.3 2 1 0 2 2 2 1 PH domain Sigma_reg_N PF13800.6 EKE39745.1 - 0.043 14.1 0.2 0.043 14.1 0.2 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Brix PF04427.18 EKE39746.1 - 6.1e-27 95.0 1.0 9e-27 94.4 1.0 1.3 1 0 0 1 1 1 1 Brix domain SWIRM PF04433.17 EKE39746.1 - 0.027 14.8 0.0 0.07 13.5 0.0 1.7 1 0 0 1 1 1 0 SWIRM domain LepB_GAP_N PF18172.1 EKE39747.1 - 0.018 14.9 1.6 0.17 11.8 0.2 2.5 2 0 0 2 2 2 0 LepB GAP domain N-terminal subdomain KH_8 PF17903.1 EKE39747.1 - 0.23 11.6 6.9 1.5 8.9 1.5 3.1 2 0 0 2 2 2 0 Krr1 KH1 domain Arm PF00514.23 EKE39747.1 - 6.6 6.9 5.6 4.6 7.4 0.1 3.4 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Rab5ip PF07019.12 EKE39748.1 - 1.3e-12 48.2 6.7 1.6e-12 47.8 6.7 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF2070 PF09843.9 EKE39748.1 - 0.019 13.3 1.4 0.019 13.2 1.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) RhoGAP PF00620.27 EKE39749.1 - 3.3e-16 59.4 0.0 8.7e-16 58.1 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain DUF725 PF05267.12 EKE39749.1 - 0.38 10.8 4.0 0.79 9.7 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF725) HEAT PF02985.22 EKE39750.1 - 2.1e-07 30.6 2.6 0.039 14.2 0.0 6.9 7 0 0 7 7 7 1 HEAT repeat HEAT_2 PF13646.6 EKE39750.1 - 6.2e-07 29.7 0.0 0.011 16.1 0.0 4.6 3 1 2 5 5 5 1 HEAT repeats HEAT_EZ PF13513.6 EKE39750.1 - 0.0072 16.8 2.1 9.1 6.9 0.0 4.8 5 0 0 5 5 5 1 HEAT-like repeat Cohesin_HEAT PF12765.7 EKE39750.1 - 0.013 15.8 1.5 0.076 13.3 0.0 2.9 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion RIX1 PF08167.12 EKE39750.1 - 0.26 11.0 0.0 0.26 11.0 0.0 5.4 6 1 0 6 6 6 0 rRNA processing/ribosome biogenesis Cnd1 PF12717.7 EKE39750.1 - 0.8 9.7 6.2 1.4 9.0 0.1 3.8 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Condensin2nSMC PF12422.8 EKE39750.1 - 0.99 9.6 7.2 4 7.6 0.1 4.5 5 0 0 5 5 5 0 Condensin II non structural maintenance of chromosomes subunit Spatacsin_C PF14649.6 EKE39751.1 - 1.7e-15 56.9 3.5 5.7e-15 55.2 3.5 1.9 1 0 0 1 1 1 1 Spatacsin C-terminus Terminase_2 PF03592.16 EKE39751.1 - 5.1 7.6 10.9 1.7 9.1 0.7 3.3 2 0 0 2 2 2 0 Terminase small subunit RabGAP-TBC PF00566.18 EKE39752.1 - 8.1e-43 146.6 8.7 1e-42 146.3 8.7 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF4796 PF16044.5 EKE39752.1 - 0.061 12.9 5.8 0.14 11.7 2.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4796) RhoGEF PF00621.20 EKE39753.1 - 5.3e-29 101.8 0.1 8.9e-29 101.0 0.1 1.4 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 EKE39753.1 - 3.9e-10 39.7 8.9 3.9e-10 39.7 8.9 2.5 2 1 0 2 2 2 1 FYVE zinc finger PH PF00169.29 EKE39753.1 - 6.3e-08 33.1 0.7 2.5e-07 31.1 0.0 2.1 2 0 0 2 2 2 1 PH domain FYVE_2 PF02318.16 EKE39753.1 - 0.0027 17.9 4.2 0.013 15.7 4.2 2.2 1 0 0 1 1 1 1 FYVE-type zinc finger C1_2 PF03107.16 EKE39753.1 - 0.0055 17.0 10.9 0.0055 17.0 10.9 2.6 3 0 0 3 3 3 1 C1 domain Thioredoxin PF00085.20 EKE39754.1 - 2.8e-28 97.9 0.1 3.2e-28 97.7 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EKE39754.1 - 1e-08 35.6 0.1 1.5e-08 35.1 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EKE39754.1 - 1.4e-07 31.2 0.1 2.2e-07 30.6 0.1 1.3 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EKE39754.1 - 9.5e-07 29.1 0.0 2e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_6 PF13848.6 EKE39754.1 - 3.3e-06 27.1 0.3 4.2e-05 23.5 0.3 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EKE39754.1 - 4.4e-05 23.4 0.1 6e-05 23.0 0.1 1.4 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 EKE39754.1 - 0.00011 22.3 0.0 0.00023 21.3 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 EKE39754.1 - 0.00021 21.0 0.1 0.0003 20.5 0.1 1.3 1 1 0 1 1 1 1 Redoxin Thioredoxin_3 PF13192.6 EKE39754.1 - 0.0011 18.9 0.1 0.002 18.1 0.1 1.5 1 1 1 2 2 2 1 Thioredoxin domain Thioredoxin_4 PF13462.6 EKE39754.1 - 0.0012 19.0 0.1 0.79 9.9 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_9 PF14595.6 EKE39754.1 - 0.016 15.0 0.0 0.02 14.7 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin Glutaredoxin PF00462.24 EKE39754.1 - 0.02 15.1 0.7 0.11 12.7 0.7 2.0 1 1 0 1 1 1 0 Glutaredoxin HyaE PF07449.11 EKE39754.1 - 0.075 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_5 PF13743.6 EKE39754.1 - 0.1 12.3 0.1 0.36 10.5 0.0 1.8 1 1 1 2 2 2 0 Thioredoxin PdxJ PF03740.13 EKE39755.1 - 0.011 14.9 2.4 0.014 14.6 2.4 1.1 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthesis protein PdxJ OmpH PF03938.14 EKE39755.1 - 0.024 15.0 12.4 0.03 14.6 12.4 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1978 PF09321.10 EKE39755.1 - 0.09 12.1 13.2 0.1 11.9 13.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) BBS1 PF14779.6 EKE39755.1 - 0.1 12.0 5.5 0.12 11.8 5.5 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 SWIRM-assoc_1 PF16495.5 EKE39755.1 - 0.3 11.1 10.1 0.2 11.6 8.3 1.6 1 1 0 1 1 1 0 SWIRM-associated region 1 FapA PF03961.13 EKE39755.1 - 0.93 8.0 12.8 1.1 7.8 12.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A FAM76 PF16046.5 EKE39755.1 - 7 5.9 11.9 7.4 5.8 11.9 1.1 1 0 0 1 1 1 0 FAM76 protein Syja_N PF02383.18 EKE39756.1 - 9e-59 199.4 0.4 1.4e-58 198.7 0.4 1.3 1 0 0 1 1 1 1 SacI homology domain v110 PF01639.17 EKE39756.1 - 0.079 12.9 0.4 0.41 10.6 0.1 2.4 2 0 0 2 2 2 0 Viral family 110 Yuri_gagarin PF15934.5 EKE39757.1 - 0.0067 16.3 1.5 0.0087 15.9 1.5 1.1 1 0 0 1 1 1 1 Yuri gagarin Ribosomal_S20p PF01649.18 EKE39757.1 - 0.2 12.3 5.7 0.34 11.6 2.6 2.3 2 1 0 2 2 2 0 Ribosomal protein S20 DUF3687 PF12459.8 EKE39757.1 - 0.29 10.7 3.8 0.55 9.8 3.8 1.5 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein UCH PF00443.29 EKE39758.1 - 5.6e-46 157.1 4.9 5.6e-46 157.1 4.9 3.4 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE39758.1 - 3.9e-23 82.6 10.2 1.9e-22 80.3 5.7 3.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Lactamase_B PF00753.27 EKE39761.1 - 1.7e-14 54.3 0.0 2.8e-12 47.1 0.0 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EKE39761.1 - 2.5e-11 43.5 0.0 7.3e-11 42.0 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 EKE39761.1 - 1.4e-10 40.9 0.0 6.5e-10 38.8 0.0 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 EKE39761.1 - 3.8e-06 27.2 0.0 9.2e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 EKE39761.1 - 6.3e-06 26.0 0.0 1.5e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 EKE39761.1 - 0.025 14.5 0.0 0.13 12.2 0.0 2.2 1 1 0 1 1 1 0 Beta-lactamase superfamily domain ArfGap PF01412.18 EKE39762.1 - 3.2e-32 111.0 0.5 3.2e-32 111.0 0.5 2.4 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Ank_5 PF13857.6 EKE39762.1 - 1.7e-11 44.1 0.3 9e-06 25.9 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKE39762.1 - 0.0001 22.8 1.7 0.00058 20.4 0.3 2.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE39762.1 - 0.022 15.3 0.0 0.072 13.7 0.0 2.0 1 1 0 1 1 1 0 Ankyrin repeats (many copies) DegQ PF08181.11 EKE39762.1 - 0.12 12.5 5.5 0.64 10.2 0.5 3.1 2 0 0 2 2 2 0 DegQ (SacQ) family A2L_zn_ribbon PF08792.10 EKE39762.1 - 0.19 11.5 2.6 6 6.7 0.0 2.6 2 0 0 2 2 2 0 A2L zinc ribbon domain LIN52 PF10044.9 EKE39762.1 - 0.37 11.5 2.9 1.8 9.3 2.3 2.4 2 0 0 2 2 2 0 Retinal tissue protein TackOD1 PF18551.1 EKE39762.1 - 0.41 10.3 5.4 0.092 12.4 0.2 2.4 2 1 0 2 2 2 0 Thaumarchaeal output domain 1 SH2 PF00017.24 EKE39764.1 - 1.2e-08 34.9 0.0 3.1e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 SH2 domain Pkinase_Tyr PF07714.17 EKE39764.1 - 0.0017 17.7 0.6 0.0049 16.2 0.5 1.7 1 1 1 2 2 2 1 Protein tyrosine kinase DUF2430 PF10353.9 EKE39764.1 - 0.0066 16.8 2.6 0.015 15.7 0.7 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF2430) Pkinase PF00069.25 EKE39764.1 - 0.0084 15.5 0.9 0.066 12.6 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain zf-C3HC4_3 PF13920.6 EKE39765.1 - 0.11 12.4 6.2 0.17 11.7 6.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn-C2H2_12 PF18112.1 EKE39765.1 - 0.2 12.2 0.8 0.2 12.2 0.8 2.5 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-RING_2 PF13639.6 EKE39765.1 - 0.44 10.9 6.2 2.4 8.6 6.9 1.8 1 1 1 2 2 2 0 Ring finger domain zf-H2C2_2 PF13465.6 EKE39765.1 - 7.1 7.2 6.7 43 4.8 6.7 2.2 1 1 0 1 1 1 0 Zinc-finger double domain Arm PF00514.23 EKE39766.1 - 4.2e-05 23.4 0.0 0.2 11.8 0.0 4.3 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat C2 PF00168.30 EKE39767.1 - 2.2e-21 76.1 0.0 4.1e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 EKE39767.1 - 0.013 15.1 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 CEP76 C2 domain WD40 PF00400.32 EKE39768.1 - 1.3e-36 123.9 20.9 1.6e-08 35.0 0.8 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE39768.1 - 1.3e-19 70.3 3.5 9.9e-06 25.8 0.0 5.9 2 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 EKE39768.1 - 7.5e-11 41.4 4.0 1.3e-10 40.7 4.0 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like eIF2A PF08662.11 EKE39768.1 - 3.9e-07 30.2 0.1 0.014 15.3 0.0 3.5 1 1 4 5 5 5 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EKE39768.1 - 0.00046 19.0 2.7 1.6 7.3 0.1 3.9 2 2 1 4 4 4 1 Nucleoporin Nup120/160 Frtz PF11768.8 EKE39768.1 - 0.0015 17.0 0.0 0.035 12.4 0.0 2.5 3 0 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 EKE39768.1 - 0.0042 16.5 0.0 0.66 9.2 0.0 3.1 1 1 2 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 EKE39768.1 - 0.011 14.7 0.2 6.3 5.7 0.0 3.3 1 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 EKE39768.1 - 0.024 14.2 0.1 3.2 7.3 0.0 2.2 1 1 0 2 2 2 0 PQQ-like domain Nucleoporin_N PF08801.11 EKE39768.1 - 0.063 12.0 0.4 8.6 5.0 0.0 3.3 2 2 1 3 3 3 0 Nup133 N terminal like PAC2 PF09754.9 EKE39769.1 - 6.7e-16 59.0 0.0 8e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 PAC2 family IF4E PF01652.18 EKE39770.1 - 3.1e-24 85.6 0.0 3.7e-24 85.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E CitT PF12431.8 EKE39770.1 - 0.15 12.4 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator Ras PF00071.22 EKE39771.1 - 1.5e-60 203.5 0.6 2.1e-60 203.0 0.6 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39771.1 - 7.3e-34 116.6 0.1 1.3e-33 115.7 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39771.1 - 5.7e-15 55.2 0.0 7.5e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE39771.1 - 1.3e-06 28.4 0.0 2.2e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE39771.1 - 6e-05 22.7 0.2 0.00022 20.9 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE39771.1 - 6.4e-05 22.9 0.4 0.11 12.4 0.1 2.5 1 1 1 3 3 3 2 RsgA GTPase AAA_22 PF13401.6 EKE39771.1 - 0.00022 21.5 0.0 0.00063 20.0 0.0 1.6 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 EKE39771.1 - 0.0048 16.6 0.4 0.0088 15.8 0.4 1.8 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EKE39771.1 - 0.013 16.0 0.2 0.024 15.2 0.2 1.8 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EKE39771.1 - 0.037 14.4 0.0 0.068 13.5 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 EKE39771.1 - 0.077 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_7 PF12775.7 EKE39771.1 - 0.087 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 EKE39771.1 - 0.17 11.9 0.1 0.87 9.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) TLD PF07534.16 EKE39772.1 - 3e-05 24.3 0.3 5.9e-05 23.3 0.3 1.5 1 0 0 1 1 1 1 TLD HHH_2 PF12826.7 EKE39772.1 - 0.0077 16.3 0.6 2.4 8.3 0.5 2.5 2 0 0 2 2 2 2 Helix-hairpin-helix motif DUF4460 PF14687.6 EKE39772.1 - 0.047 13.7 4.7 0.11 12.6 4.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4460) Mt_ATP-synt_D PF05873.12 EKE39772.1 - 0.055 13.3 5.9 0.091 12.6 4.8 1.9 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Phage_GPO PF05929.11 EKE39772.1 - 0.06 13.0 1.6 0.091 12.4 1.6 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase CAF1 PF04857.20 EKE39772.1 - 0.12 11.5 1.7 0.15 11.2 1.7 1.3 1 0 0 1 1 1 0 CAF1 family ribonuclease FlaG PF03646.15 EKE39772.1 - 1.2 9.3 11.7 0.75 10.0 8.5 2.3 2 1 0 2 2 2 0 FlaG protein AAA_23 PF13476.6 EKE39772.1 - 3.5 8.1 13.1 1.5 9.3 10.3 1.7 2 0 0 2 2 2 0 AAA domain Ras PF00071.22 EKE39773.1 - 3.3e-27 95.1 0.3 4e-27 94.8 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39773.1 - 1.2e-13 51.3 0.0 2e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EKE39773.1 - 6.2e-09 35.7 0.1 8.4e-09 35.2 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE39773.1 - 3.6e-05 23.8 0.0 5.6e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE39773.1 - 0.0008 18.8 1.2 0.0019 17.6 1.2 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE39773.1 - 0.002 18.0 1.8 0.56 10.1 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase MeaB PF03308.16 EKE39773.1 - 0.0049 15.9 0.5 0.2 10.6 0.1 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Ploopntkinase3 PF18751.1 EKE39773.1 - 0.097 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_28 PF13521.6 EKE39773.1 - 0.16 12.2 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Got1 PF04178.12 EKE39774.1 - 1.5e-12 47.9 26.4 3e-12 46.9 26.4 1.5 1 1 0 1 1 1 1 Got1/Sft2-like family Claudin_2 PF13903.6 EKE39774.1 - 0.0015 18.3 11.4 0.099 12.4 1.9 2.0 2 0 0 2 2 2 2 PMP-22/EMP/MP20/Claudin tight junction Pmp3 PF01679.17 EKE39775.1 - 4.3e-16 58.8 16.6 4.3e-16 58.8 16.6 1.6 1 1 1 2 2 2 1 Proteolipid membrane potential modulator PhoR PF11808.8 EKE39775.1 - 2.2 8.8 5.8 2.5 8.6 5.8 1.1 1 0 0 1 1 1 0 Phosphate regulon sensor protein PhoR Prefoldin PF02996.17 EKE39776.1 - 2.7e-23 82.1 1.6 3.1e-23 82.0 1.6 1.0 1 0 0 1 1 1 1 Prefoldin subunit K-box PF01486.17 EKE39776.1 - 0.082 13.1 0.2 0.082 13.1 0.2 1.8 2 0 0 2 2 2 0 K-box region DUF1798 PF08807.10 EKE39777.1 - 0.043 13.9 0.5 0.1 12.7 0.5 1.6 1 0 0 1 1 1 0 Bacterial domain of unknown function (DUF1798) POTRA_TamA_1 PF17243.2 EKE39777.1 - 0.067 13.3 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 POTRA domain TamA domain 1 Golgin_A5 PF09787.9 EKE39778.1 - 0.0013 18.3 14.5 0.0015 18.0 14.5 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF787 PF05619.11 EKE39778.1 - 0.0028 16.9 5.2 0.0032 16.7 5.2 1.0 1 0 0 1 1 1 1 Borrelia burgdorferi protein of unknown function (DUF787) Med29 PF11568.8 EKE39778.1 - 0.009 16.2 5.8 0.1 12.8 0.3 2.1 1 1 1 2 2 2 2 Mediator complex subunit 29 Lyase_8_N PF08124.11 EKE39778.1 - 0.027 13.4 2.0 0.031 13.2 2.0 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain Lectin_N PF03954.14 EKE39778.1 - 0.2 11.4 4.6 0.32 10.8 2.2 1.9 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain OmpH PF03938.14 EKE39778.1 - 0.21 11.9 15.6 0.28 11.5 15.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SpoU_sub_bind PF08032.12 EKE39778.1 - 0.27 11.5 5.4 0.68 10.3 2.2 2.5 1 1 1 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding TMF_TATA_bd PF12325.8 EKE39778.1 - 0.3 11.3 14.0 0.28 11.4 12.9 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Wax2_C PF12076.8 EKE39778.1 - 0.3 10.8 6.1 3.2 7.5 0.4 2.0 1 1 1 2 2 2 0 WAX2 C-terminal domain Cep57_MT_bd PF06657.13 EKE39778.1 - 0.49 10.9 12.9 2.9 8.4 2.5 2.8 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 FAP206 PF12018.8 EKE39778.1 - 0.51 9.8 10.8 0.32 10.5 8.9 1.5 1 1 1 2 2 2 0 Domain of unknown function HMMR_N PF15905.5 EKE39778.1 - 1.2 8.5 20.0 8.8 5.7 20.0 1.9 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal TMPIT PF07851.13 EKE39778.1 - 3.3 6.9 13.0 3.7 6.7 12.4 1.3 1 1 0 1 1 1 0 TMPIT-like protein DUF4404 PF14357.6 EKE39778.1 - 3.8 8.2 8.4 3.5 8.3 6.1 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4404) GrpE PF01025.19 EKE39778.1 - 4.9 6.8 16.2 80 2.8 16.3 2.0 1 1 0 1 1 1 0 GrpE AAA_23 PF13476.6 EKE39778.1 - 6.2 7.3 21.8 8.1 6.9 21.8 1.2 1 0 0 1 1 1 0 AAA domain CLASP_N PF12348.8 EKE39779.1 - 0.0074 15.9 10.5 3.5 7.1 0.1 4.4 3 1 1 4 4 4 3 CLASP N terminal Rogdi_lz PF10259.9 EKE39780.1 - 2.4e-27 96.1 0.1 2.8e-27 95.9 0.1 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein DSHCT PF08148.12 EKE39781.1 - 4.9e-39 133.6 0.4 2.2e-38 131.5 0.4 2.1 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EKE39781.1 - 1.1e-16 61.1 3.1 1.7e-16 60.5 0.2 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 EKE39781.1 - 2.8e-07 30.7 4.2 2.8e-07 30.7 4.2 3.5 3 1 1 4 4 4 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EKE39781.1 - 1.8e-05 25.0 0.3 0.00025 21.3 0.0 3.3 3 1 0 3 3 3 1 Helicase conserved C-terminal domain Mon1 PF03164.14 EKE39782.1 - 1.6e-24 86.8 1.7 2e-24 86.4 1.7 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 Lipoprotein_7 PF01540.16 EKE39783.1 - 0.042 13.1 13.9 0.16 11.2 2.4 2.4 1 1 1 2 2 2 0 Adhesin lipoprotein HCMV_UL139 PF12507.8 EKE39783.1 - 0.65 10.4 5.2 0.17 12.3 1.7 1.8 2 0 0 2 2 2 0 Human Cytomegalovirus UL139 protein MRP-L47 PF06984.13 EKE39783.1 - 7.1 6.8 7.9 1.3 9.2 0.8 2.7 2 1 0 3 3 3 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) UCH PF00443.29 EKE39784.1 - 8.4e-65 218.8 1.2 8.4e-65 218.8 1.2 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE39784.1 - 4.8e-15 56.0 14.6 1.3e-06 28.2 6.7 3.4 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EKE39784.1 - 0.022 15.4 0.3 0.022 15.4 0.3 4.7 3 1 1 4 4 4 0 DUSP domain Memo PF01875.17 EKE39785.1 - 1e-41 142.9 0.0 1.2e-41 142.7 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Herpes_U34 PF04541.13 EKE39786.1 - 0.1 11.9 0.3 0.16 11.2 0.3 1.3 1 0 0 1 1 1 0 Herpesvirus virion protein U34 CTP_transf_1 PF01148.20 EKE39787.1 - 0.00018 21.4 11.9 0.00027 20.8 11.9 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family DUF92 PF01940.16 EKE39787.1 - 3.4 7.0 6.7 6.7 6.1 6.7 1.6 1 1 0 1 1 1 0 Integral membrane protein DUF92 Proteasome PF00227.26 EKE39789.1 - 1.2e-38 132.5 2.0 1.4e-38 132.3 2.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Cnd3 PF12719.7 EKE39790.1 - 2.3e-09 36.9 3.4 8e-09 35.1 3.4 1.9 1 1 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 EKE39790.1 - 3.7e-06 26.7 0.0 1.2 9.6 0.0 5.5 6 0 0 6 6 6 1 HEAT repeat CLASP_N PF12348.8 EKE39790.1 - 0.00033 20.3 6.0 0.0086 15.7 0.3 3.0 2 1 0 3 3 3 2 CLASP N terminal HEAT_2 PF13646.6 EKE39790.1 - 0.00065 20.0 0.0 0.057 13.8 0.0 3.5 3 1 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 EKE39790.1 - 0.039 14.5 0.4 15 6.2 0.0 4.1 4 0 0 4 4 4 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EKE39790.1 - 0.11 13.1 2.2 27 5.5 0.1 4.3 3 1 0 4 4 4 0 Vacuolar 14 Fab1-binding region Peptidase_M3_N PF08439.10 EKE39790.1 - 0.17 12.2 1.2 0.43 10.9 0.2 2.3 2 0 0 2 2 2 0 Oligopeptidase F Cnd1 PF12717.7 EKE39790.1 - 0.27 11.3 15.9 2.1 8.4 0.4 5.9 3 1 3 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Y_phosphatase PF00102.27 EKE39791.1 - 5.4e-52 176.7 1.8 2.9e-46 158.0 0.5 2.1 2 0 0 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 EKE39791.1 - 0.0046 16.8 0.0 0.021 14.6 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EKE39791.1 - 0.02 14.9 0.1 0.041 13.8 0.1 1.7 1 1 0 1 1 1 0 Tyrosine phosphatase family TLD PF07534.16 EKE39792.1 - 1.1e-05 25.7 0.2 1.7e-05 25.0 0.2 1.4 1 0 0 1 1 1 1 TLD Phospholip_B PF04916.13 EKE39793.1 - 2.6e-130 435.5 12.7 3.2e-130 435.2 12.7 1.0 1 0 0 1 1 1 1 Phospholipase B MIB_HERC2 PF06701.13 EKE39793.1 - 0.14 12.4 0.2 0.48 10.7 0.2 1.9 1 0 0 1 1 1 0 Mib_herc2 Amidohydro_1 PF01979.20 EKE39794.1 - 3.1e-25 89.2 0.0 4.3e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EKE39794.1 - 5.5e-13 49.2 0.0 1.3e-06 28.1 0.0 2.4 3 0 0 3 3 3 2 Amidohydrolase family Usp PF00582.26 EKE39794.1 - 0.11 13.0 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 Universal stress protein family Urease_alpha PF00449.20 EKE39794.1 - 0.12 12.8 0.2 0.23 11.8 0.2 1.5 1 0 0 1 1 1 0 Urease alpha-subunit, N-terminal domain PAP2 PF01569.21 EKE39795.1 - 2e-22 79.4 2.7 2.2e-22 79.3 0.5 1.9 1 1 1 2 2 2 1 PAP2 superfamily PalH PF08733.10 EKE39795.1 - 0.00026 20.1 2.5 0.00031 19.9 2.5 1.3 1 1 0 1 1 1 1 PalH/RIM21 BPD_transp_2 PF02653.16 EKE39795.1 - 0.045 12.9 1.5 0.11 11.7 1.6 1.7 1 1 1 2 2 2 0 Branched-chain amino acid transport system / permease component PIRT PF15099.6 EKE39795.1 - 0.12 12.0 1.4 0.25 10.9 1.4 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Avl9 PF09794.9 EKE39797.1 - 9.5e-10 37.7 0.1 2.6e-08 33.0 0.0 2.0 1 1 1 2 2 2 2 Transport protein Avl9 PadR PF03551.14 EKE39797.1 - 0.12 12.4 0.0 13 5.8 0.0 2.2 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family DUF2347 PF09804.9 EKE39797.1 - 0.15 11.6 0.3 0.23 11.0 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Myotub-related PF06602.14 EKE39798.1 - 4.1e-88 295.7 3.1 4.1e-88 295.7 3.1 1.8 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain DSPc PF00782.20 EKE39798.1 - 1.7e-05 24.6 1.1 5.7e-05 22.9 0.0 2.4 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EKE39798.1 - 0.0091 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family LMF1 PF06762.14 EKE39799.1 - 0.064 12.4 4.9 0.023 13.8 2.5 1.4 1 1 0 1 1 1 0 Lipase maturation factor Phage_holin_3_6 PF07332.11 EKE39799.1 - 0.092 12.8 0.1 0.092 12.8 0.1 2.9 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Promethin PF16015.5 EKE39799.1 - 0.34 10.8 0.1 0.34 10.8 0.1 3.1 3 0 0 3 3 3 0 Promethin DUF4064 PF13273.6 EKE39799.1 - 0.57 10.5 25.7 0.77 10.1 16.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Claudin_2 PF13903.6 EKE39799.1 - 2.5 7.8 19.0 0.014 15.1 6.9 2.7 1 1 2 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction WD40_3 PF15911.5 EKE39800.1 - 0.13 12.2 0.1 1.2 9.2 0.0 2.1 2 0 0 2 2 2 0 WD domain, G-beta repeat VASt PF16016.5 EKE39801.1 - 1.4e-34 119.7 2.2 7.6e-24 84.9 0.1 2.5 2 0 0 2 2 2 2 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EKE39801.1 - 4.8e-05 23.2 0.5 0.00022 21.1 0.5 2.1 1 0 0 1 1 1 1 GRAM domain Aa_trans PF01490.18 EKE39802.1 - 2.2e-22 79.4 32.7 2.9e-22 79.0 32.7 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EKE39802.1 - 2.9e-05 23.3 11.3 2.9e-05 23.3 11.3 2.6 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family DnaJ_C PF01556.18 EKE39803.1 - 2.8e-09 37.2 0.7 2e-07 31.2 0.7 3.5 2 1 0 2 2 2 1 DnaJ C terminal domain Myb_DNA-binding PF00249.31 EKE39804.1 - 2.5e-26 91.6 15.0 1.3e-10 41.3 0.1 6.4 5 1 0 5 5 5 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE39804.1 - 1.2e-18 67.0 12.6 5.5e-08 32.9 0.2 6.1 3 1 2 5 5 5 4 Myb-like DNA-binding domain dCache_3 PF14827.6 EKE39804.1 - 0.00088 19.0 0.0 0.011 15.4 0.0 2.2 2 0 0 2 2 2 1 Double sensory domain of two-component sensor kinase SLIDE PF09111.10 EKE39804.1 - 0.012 15.6 0.2 0.012 15.6 0.2 5.4 5 2 0 6 6 6 0 SLIDE NT5C PF06941.12 EKE39804.1 - 0.24 11.2 3.3 3 7.7 0.1 3.7 4 1 1 5 5 5 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Cgr1 PF03879.14 EKE39804.1 - 1.1 9.7 7.3 7.2 7.0 7.3 2.5 1 0 0 1 1 1 0 Cgr1 family YjcQ PF09639.10 EKE39804.1 - 1.6 9.0 8.0 0.81 9.9 1.3 3.6 3 1 0 3 3 3 0 YjcQ protein PX PF00787.24 EKE39805.1 - 2.5e-20 72.5 0.2 3.2e-20 72.2 0.2 1.0 1 0 0 1 1 1 1 PX domain Potyvirid-P3 PF13608.6 EKE39805.1 - 0.037 13.1 0.8 0.046 12.8 0.8 1.1 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein Occludin_ELL PF07303.13 EKE39805.1 - 0.051 14.3 2.6 0.11 13.2 2.6 1.5 1 0 0 1 1 1 0 Occludin homology domain EF-hand_6 PF13405.6 EKE39806.1 - 0.0016 18.2 2.1 1 9.4 0.1 5.7 7 0 0 7 7 7 1 EF-hand domain EF-hand_9 PF14658.6 EKE39806.1 - 0.045 14.1 0.0 0.25 11.7 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain TFIIA_gamma_N PF02268.16 EKE39806.1 - 0.14 12.2 0.6 1.7 8.7 0.1 3.2 3 1 0 3 3 3 0 Transcription initiation factor IIA, gamma subunit, helical domain QSOX_Trx1 PF18108.1 EKE39806.1 - 0.16 12.2 1.1 1.4 9.2 0.1 2.8 2 0 0 2 2 2 0 QSOX Trx-like domain Ribosomal_S26e PF01283.19 EKE39807.1 - 8.7e-49 164.5 12.0 1.4e-48 163.8 12.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S26e SRP19 PF01922.17 EKE39807.1 - 0.0071 17.3 0.9 0.012 16.5 0.9 1.5 1 1 0 1 1 1 1 SRP19 protein Mu-like_Com PF10122.9 EKE39807.1 - 0.0092 15.4 0.2 0.0092 15.4 0.2 1.6 2 0 0 2 2 2 1 Mu-like prophage protein Com Fer4_7 PF12838.7 EKE39807.1 - 0.0096 16.5 3.3 0.41 11.3 0.7 2.5 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4 PF00037.27 EKE39807.1 - 0.22 11.4 5.0 1.2 9.0 1.0 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 EKE39807.1 - 0.32 11.6 4.6 0.21 12.2 2.3 1.8 2 1 1 3 3 3 0 4Fe-4S dicluster domain zf-ribbon_3 PF13248.6 EKE39807.1 - 0.45 10.0 4.5 1.2 8.7 1.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Fer4_2 PF12797.7 EKE39807.1 - 0.62 10.3 4.2 3.4 8.0 1.6 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_4 PF12800.7 EKE39807.1 - 1.4 9.6 5.5 3.3 8.5 2.2 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain CAF1 PF04857.20 EKE39808.1 - 1.3e-12 47.5 2.2 1.5e-07 30.9 0.6 3.4 1 1 2 3 3 3 3 CAF1 family ribonuclease SecE PF00584.20 EKE39809.1 - 1.5e-12 47.2 0.0 1.7e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex SPT_ssu-like PF11779.8 EKE39809.1 - 0.05 13.2 0.0 0.069 12.8 0.0 1.2 1 0 0 1 1 1 0 Small subunit of serine palmitoyltransferase-like Rax2 PF12768.7 EKE39809.1 - 0.14 11.5 0.0 0.16 11.4 0.0 1.0 1 0 0 1 1 1 0 Cortical protein marker for cell polarity TTL PF03133.15 EKE39810.1 - 8.5e-39 133.4 10.5 1.5e-38 132.7 10.5 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family MCM PF00493.23 EKE39811.1 - 2.2e-71 239.5 0.0 4.1e-71 238.7 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 EKE39811.1 - 3.3e-16 59.5 0.6 8.4e-16 58.2 0.6 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 EKE39811.1 - 9.8e-15 54.5 0.6 2.6e-14 53.2 0.6 1.6 1 0 0 1 1 1 1 MCM OB domain AAA_5 PF07728.14 EKE39811.1 - 1.3e-08 34.9 0.0 3.7e-08 33.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EKE39811.1 - 1.7e-07 30.9 3.6 0.00019 20.9 0.0 3.2 3 1 0 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EKE39811.1 - 0.0007 19.3 1.1 0.67 9.7 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Sigma54_activat PF00158.26 EKE39811.1 - 0.0078 15.9 0.1 2.8 7.6 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA PF00004.29 EKE39811.1 - 0.031 14.7 0.0 0.031 14.7 0.0 3.7 4 2 1 5 5 4 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EKE39811.1 - 0.048 14.1 0.2 0.17 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EKE39811.1 - 0.11 12.2 0.6 0.65 9.7 0.6 2.2 1 1 0 1 1 1 0 AAA domain Zn-ribbon_8 PF09723.10 EKE39811.1 - 0.16 12.1 1.0 0.44 10.7 1.0 1.8 1 0 0 1 1 1 0 Zinc ribbon domain RuvB_N PF05496.12 EKE39811.1 - 0.24 11.1 1.4 0.5 10.1 0.1 2.3 3 1 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EKE39811.1 - 1.1 9.8 6.0 1.8 9.1 0.1 4.1 3 2 0 3 3 3 0 AAA domain PAP_assoc PF03828.19 EKE39813.1 - 3.2e-08 33.7 0.2 1.1e-07 32.0 0.2 2.0 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EKE39813.1 - 1.6e-06 28.3 0.8 4e-06 27.0 0.2 2.1 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 EKE39813.1 - 0.00095 19.2 1.3 0.0033 17.5 0.3 2.6 2 1 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase PRKCSH PF07915.13 EKE39814.1 - 6.5e-05 23.9 1.9 6.5e-05 23.9 1.9 2.2 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein DUF21 PF01595.20 EKE39815.1 - 2.3 7.9 7.8 57 3.4 7.2 2.5 1 1 0 1 1 1 0 Cyclin M transmembrane N-terminal domain RabGAP-TBC PF00566.18 EKE39816.1 - 2.1e-30 106.0 14.0 5.1e-29 101.5 14.0 2.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Galactosyl_T PF01762.21 EKE39817.1 - 3.9e-15 56.2 0.3 6.4e-15 55.5 0.3 1.2 1 0 0 1 1 1 1 Galactosyltransferase FHA PF00498.26 EKE39818.1 - 4.9e-14 52.4 0.1 9.2e-14 51.6 0.1 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EKE39818.1 - 1.9e-09 37.7 0.0 4.7e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4_4 PF15227.6 EKE39818.1 - 8.6e-07 29.0 14.9 2.1e-06 27.7 14.9 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EKE39818.1 - 6.9e-06 25.8 8.6 1.4e-05 24.8 8.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE39818.1 - 7.1e-06 25.9 11.1 5.1e-05 23.2 7.0 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EKE39818.1 - 2e-05 24.4 9.3 2e-05 24.4 9.3 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE39818.1 - 0.0002 21.1 12.0 0.0002 21.1 12.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EKE39818.1 - 0.00086 19.2 13.6 0.013 15.5 14.0 2.4 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EKE39818.1 - 0.018 14.9 9.7 0.24 11.3 10.2 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 EKE39818.1 - 0.14 12.0 4.7 0.43 10.4 4.7 1.9 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 EKE39818.1 - 0.36 11.2 16.8 0.074 13.4 11.8 2.5 2 1 1 3 3 3 0 Ring finger domain LRR_4 PF12799.7 EKE39819.1 - 0.00011 22.4 25.4 0.38 11.3 0.0 7.4 6 3 1 7 7 7 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE39819.1 - 0.047 13.5 15.2 1.5 8.7 0.1 5.3 3 2 2 5 5 5 0 Leucine rich repeat LRR_6 PF13516.6 EKE39819.1 - 0.6 10.3 10.5 7.3 6.9 0.0 5.2 6 0 0 6 6 6 0 Leucine Rich repeat Pkinase PF00069.25 EKE39820.1 - 2.5e-65 220.5 0.0 3.3e-65 220.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39820.1 - 3.7e-34 118.2 0.0 5.3e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE39820.1 - 2e-08 33.9 0.1 7.1e-08 32.1 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EKE39820.1 - 1.3e-06 27.9 0.0 2.5e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EKE39820.1 - 0.00099 18.2 0.1 0.0014 17.6 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EKE39820.1 - 0.0032 17.4 0.0 0.013 15.4 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EKE39820.1 - 0.0036 16.2 0.1 0.015 14.1 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Prefoldin PF02996.17 EKE39821.1 - 1.5e-06 28.1 0.9 1.5e-06 28.1 0.9 2.3 1 1 0 2 2 2 1 Prefoldin subunit M11L PF11099.8 EKE39821.1 - 0.13 12.5 3.3 0.14 12.4 2.0 1.7 2 0 0 2 2 2 0 Apoptosis regulator M11L like DUF4242 PF14026.6 EKE39821.1 - 0.25 11.6 1.3 0.47 10.7 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4242) LMBR1 PF04791.16 EKE39821.1 - 6.5 5.5 7.4 7.5 5.3 7.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Nexin_C PF08628.12 EKE39822.1 - 0.32 11.6 2.1 0.9 10.1 0.2 2.4 2 0 0 2 2 2 0 Sorting nexin C terminal DUF3987 PF13148.6 EKE39824.1 - 0.24 10.4 4.1 0.47 9.4 4.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) RasGEF PF00617.19 EKE39825.1 - 4.8e-10 39.9 4.9 9.2e-10 39.0 1.4 2.5 2 0 0 2 2 2 1 RasGEF domain Rubrerythrin PF02915.17 EKE39826.1 - 6.4e-31 107.6 4.1 9.1e-31 107.1 4.1 1.2 1 0 0 1 1 1 1 Rubrerythrin Ferritin PF00210.24 EKE39826.1 - 4e-10 39.8 2.6 5.1e-10 39.5 2.6 1.1 1 0 0 1 1 1 1 Ferritin-like domain HypA PF01155.19 EKE39826.1 - 0.0011 18.9 0.1 0.0021 18.1 0.1 1.5 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.14 EKE39826.1 - 0.0027 17.7 1.0 0.0078 16.2 1.0 1.8 1 0 0 1 1 1 1 Adenylate kinase, active site lid RNA_POL_M_15KD PF02150.16 EKE39826.1 - 0.0032 17.3 0.0 0.0032 17.3 0.0 1.9 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn-ribbon_8 PF09723.10 EKE39826.1 - 0.0038 17.3 1.1 0.0038 17.3 1.1 1.7 2 0 0 2 2 1 1 Zinc ribbon domain FA_desaturase_2 PF03405.14 EKE39826.1 - 0.011 14.6 2.8 0.081 11.8 0.7 2.5 2 1 1 3 3 3 0 Fatty acid desaturase DUF4379 PF14311.6 EKE39826.1 - 0.011 16.0 0.7 0.022 15.1 0.7 1.5 1 0 0 1 1 1 0 Probable Zinc-ribbon domain F_bP_aldolase PF01116.20 EKE39826.1 - 0.047 13.2 0.1 0.067 12.7 0.1 1.3 1 1 0 1 1 1 0 Fructose-bisphosphate aldolase class-II MCM_OB PF17207.3 EKE39826.1 - 0.076 12.9 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 MCM OB domain A2L_zn_ribbon PF08792.10 EKE39826.1 - 0.081 12.7 0.4 3.3 7.5 0.1 2.4 2 0 0 2 2 2 0 A2L zinc ribbon domain T4_neck-protein PF11649.8 EKE39826.1 - 0.098 12.0 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Virus neck protein zf-C2HC5 PF06221.13 EKE39826.1 - 0.12 12.4 0.4 0.22 11.5 0.4 1.4 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type UPF0547 PF10571.9 EKE39826.1 - 0.16 12.1 7.2 0.29 11.3 0.7 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 YhfH PF14149.6 EKE39826.1 - 8.8 6.4 6.7 3.4 7.7 0.9 2.3 1 1 1 2 2 2 0 YhfH-like protein Ank_2 PF12796.7 EKE39827.1 - 2.4e-31 108.2 0.5 4.9e-13 49.5 0.0 3.4 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKE39827.1 - 2.5e-21 73.5 0.1 0.0015 18.8 0.0 5.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 EKE39827.1 - 1e-19 70.6 0.1 7.5e-09 36.0 0.0 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE39827.1 - 5.1e-17 61.7 0.0 1e-05 25.7 0.0 4.2 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EKE39827.1 - 1.2e-16 60.3 0.1 0.009 16.4 0.1 5.2 5 0 0 5 5 5 3 Ankyrin repeat DUF249 PF03158.13 EKE39827.1 - 0.0013 18.4 0.3 2.8 7.6 0.0 3.1 3 0 0 3 3 3 2 Multigene family 530 protein CoA_binding_2 PF13380.6 EKE39827.1 - 0.043 14.3 0.0 0.11 12.9 0.0 1.7 2 0 0 2 2 2 0 CoA binding domain IBR PF01485.21 EKE39828.1 - 1.4e-13 50.8 48.1 7.2e-09 35.7 11.1 4.4 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 EKE39828.1 - 0.00022 21.0 1.7 0.00022 21.0 1.7 4.0 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE39828.1 - 0.012 15.6 3.0 0.012 15.6 3.0 3.8 3 0 0 3 3 3 0 RING-type zinc-finger zf-RING_2 PF13639.6 EKE39828.1 - 0.024 15.0 5.2 0.024 15.0 5.2 4.5 3 2 0 3 3 3 0 Ring finger domain zf-C3HC4_4 PF15227.6 EKE39828.1 - 6 7.1 31.0 0.085 13.0 4.1 4.3 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING Seryl_tRNA_N PF02403.22 EKE39829.1 - 0.0013 19.0 21.0 0.0013 19.0 21.0 4.3 2 1 2 5 5 5 1 Seryl-tRNA synthetase N-terminal domain DUF948 PF06103.11 EKE39829.1 - 4.2 7.7 8.1 2.8 8.2 4.7 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DHHC PF01529.20 EKE39830.1 - 1.1e-22 80.6 25.6 3.9e-20 72.3 25.6 2.2 1 1 0 1 1 1 1 DHHC palmitoyltransferase Rhodanese PF00581.20 EKE39831.1 - 4.5e-11 43.2 0.0 1.1e-10 42.0 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase_Tyr PF07714.17 EKE39832.1 - 3.9e-56 190.2 0.0 7.4e-56 189.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE39832.1 - 1.1e-40 139.6 0.0 2.3e-40 138.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain FMN_red PF03358.15 EKE39833.1 - 6.4e-23 81.2 0.0 8.2e-23 80.9 0.0 1.2 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EKE39833.1 - 5.8e-15 55.5 0.0 7.3e-15 55.2 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold MFS_1 PF07690.16 EKE39834.1 - 8.8e-31 107.1 22.5 4.9e-20 71.8 9.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Connexin PF00029.19 EKE39834.1 - 0.056 13.2 3.6 4.8 6.9 0.1 2.7 2 0 0 2 2 2 0 Connexin Ctr PF04145.15 EKE39834.1 - 0.085 13.5 10.5 2.4 8.8 8.7 3.3 2 1 0 2 2 2 0 Ctr copper transporter family DUF2500 PF10694.9 EKE39834.1 - 0.17 12.4 3.8 9.6 6.8 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) WYL PF13280.6 EKE39834.1 - 0.19 11.7 0.7 0.39 10.8 0.7 1.4 1 0 0 1 1 1 0 WYL domain GRIM-19 PF06212.12 EKE39834.1 - 9.8 6.1 7.0 2.7e+02 1.5 5.0 3.3 2 1 0 2 2 2 0 GRIM-19 protein Ank_2 PF12796.7 EKE39835.1 - 2.2e-15 57.0 0.0 9.1e-12 45.4 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE39835.1 - 4.5e-14 52.6 0.0 2.2e-07 31.3 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE39835.1 - 2.5e-12 46.8 0.0 3.1e-08 33.7 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EKE39835.1 - 2.9e-10 40.1 0.0 0.00017 21.9 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EKE39835.1 - 5.1e-08 32.6 0.0 0.045 14.3 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Glyco_hydro_81 PF03639.13 EKE39836.1 - 0.063 12.4 0.1 0.089 11.9 0.1 1.2 1 1 0 1 1 1 0 Glycosyl hydrolase family 81 N-terminal domain CH PF00307.31 EKE39837.1 - 6.5e-06 26.3 2.9 6.6e-06 26.3 0.0 2.6 3 0 0 3 3 3 1 Calponin homology (CH) domain LRR_8 PF13855.6 EKE39839.1 - 2e-09 37.1 11.9 5.8e-06 26.0 0.2 3.6 3 1 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EKE39839.1 - 5.7e-06 26.6 0.4 5.7e-06 26.6 0.4 5.2 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EKE39839.1 - 0.0021 18.4 7.3 8.4 7.4 0.0 5.8 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_9 PF14580.6 EKE39839.1 - 0.0035 16.9 5.1 0.03 13.8 2.3 2.9 2 1 1 3 3 3 2 Leucine-rich repeat eRF1_2 PF03464.15 EKE39839.1 - 0.013 15.8 0.0 0.031 14.6 0.0 1.6 1 0 0 1 1 1 0 eRF1 domain 2 NYD-SP28_assoc PF14775.6 EKE39839.1 - 0.092 12.9 2.0 0.18 11.9 0.6 2.3 2 0 0 2 2 2 0 Sperm tail C-terminal domain LRR_6 PF13516.6 EKE39839.1 - 0.27 11.4 8.9 0.68 10.1 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich repeat partial_CstF PF15861.5 EKE39839.1 - 5.3 6.9 6.6 1.9 8.3 0.8 2.8 2 0 0 2 2 2 0 Partial cleavage stimulation factor domain TLD PF07534.16 EKE39841.1 - 4.8e-08 33.3 0.5 1.8e-07 31.4 0.1 2.1 2 0 0 2 2 2 1 TLD YabA PF06156.13 EKE39841.1 - 0.0017 18.9 8.9 0.0017 18.9 8.9 3.0 1 1 2 3 3 3 1 Initiation control protein YabA TSC22 PF01166.18 EKE39841.1 - 0.0022 18.3 5.5 0.0022 18.3 5.5 4.2 4 2 1 5 5 5 1 TSC-22/dip/bun family ApoO PF09769.9 EKE39841.1 - 0.27 11.2 2.1 0.71 9.8 2.1 1.7 1 1 0 1 1 1 0 Apolipoprotein O DUF3086 PF11285.8 EKE39841.1 - 0.53 9.3 13.8 1.2 8.1 13.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3086) PspB PF06667.12 EKE39841.1 - 0.71 10.0 5.5 3.1 7.9 2.4 2.5 1 1 1 2 2 2 0 Phage shock protein B Tweety PF04906.13 EKE39841.1 - 4.3 5.9 5.9 5.8 5.5 5.9 1.3 1 0 0 1 1 1 0 Tweety Fmp27_WPPW PF10359.9 EKE39841.1 - 6.5 5.5 27.4 0.35 9.7 20.8 1.8 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF1931 PF09123.11 EKE39842.1 - 0.034 14.2 1.4 0.054 13.6 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1931) NPV_P10 PF05531.12 EKE39842.1 - 1.3 9.6 5.9 1.3 9.6 0.1 3.4 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein RuvB_C PF05491.13 EKE39843.1 - 0.22 11.4 1.3 1.2 9.1 0.1 2.3 2 0 0 2 2 2 0 RuvB C-terminal winged helix domain WD40 PF00400.32 EKE39844.1 - 8.9e-35 118.1 19.9 2.2e-07 31.4 0.0 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EKE39844.1 - 1.8e-07 30.5 2.9 0.00027 20.0 0.1 3.9 2 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EKE39844.1 - 6.2e-06 26.4 2.1 0.036 14.3 0.0 4.1 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EKE39844.1 - 1.1e-05 24.3 7.8 0.65 8.6 0.1 4.1 3 1 1 4 4 4 4 Nucleoporin Nup120/160 PD40 PF07676.12 EKE39844.1 - 0.0091 15.9 1.0 0.21 11.6 0.1 3.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat RIH_assoc PF08454.11 EKE39845.1 - 0.06 13.2 0.4 0.19 11.6 0.4 1.9 1 0 0 1 1 1 0 RyR and IP3R Homology associated Ribosomal_L44 PF00935.19 EKE39846.1 - 5.2e-34 116.6 17.5 6.9e-34 116.2 17.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 NOB1_Zn_bind PF08772.11 EKE39846.1 - 0.00077 19.6 0.8 0.00077 19.6 0.8 2.2 1 1 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like Pkinase_Tyr PF07714.17 EKE39847.1 - 1.4e-35 122.9 0.0 2.2e-35 122.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE39847.1 - 2.8e-31 108.8 0.1 4.9e-31 108.1 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain TIG PF01833.24 EKE39847.1 - 9.2e-10 38.5 0.5 9.2e-10 38.5 0.5 2.9 3 0 0 3 3 3 1 IPT/TIG domain Saf_2TM PF18303.1 EKE39847.1 - 0.00011 21.8 4.9 0.0002 21.0 4.9 1.3 1 0 0 1 1 1 1 SAVED-fused 2TM effector domain DUF4389 PF14333.6 EKE39847.1 - 0.17 11.8 0.6 0.37 10.7 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) zf-UBP_var PF17807.1 EKE39847.1 - 0.2 11.4 2.6 8.8 6.2 0.1 2.7 2 0 0 2 2 2 0 Variant UBP zinc finger TMEM154 PF15102.6 EKE39847.1 - 0.47 10.3 4.4 0.95 9.4 4.4 1.4 1 0 0 1 1 1 0 TMEM154 protein family Endomucin PF07010.12 EKE39847.1 - 0.79 9.7 2.8 2 8.4 2.8 1.6 1 0 0 1 1 1 0 Endomucin DUF1604 PF07713.13 EKE39848.1 - 9.7e-06 25.3 2.7 1.2e-05 25.1 0.1 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF1604) zf-C2H2_9 PF16293.5 EKE39848.1 - 0.00037 20.3 1.5 0.0006 19.6 0.1 2.0 2 0 0 2 2 2 1 C2H2 type zinc-finger (1 copy) Prophage_tail PF06605.11 EKE39848.1 - 0.015 14.6 3.2 0.023 13.9 3.2 1.5 1 0 0 1 1 1 0 Prophage endopeptidase tail SMC_N PF02463.19 EKE39849.1 - 4.9e-19 68.7 26.7 2.3e-15 56.6 0.3 4.5 3 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EKE39849.1 - 3.4e-13 50.5 36.9 3.4e-13 50.5 36.9 6.6 1 1 3 4 4 4 1 AAA domain AAA_15 PF13175.6 EKE39849.1 - 3.2e-11 43.6 49.0 3.2e-11 43.6 49.0 4.2 1 1 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EKE39849.1 - 0.0016 18.3 0.0 0.0016 18.3 0.0 3.9 3 2 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKE39849.1 - 0.0021 17.8 0.0 0.0043 16.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EKE39849.1 - 0.1 13.1 0.0 0.1 13.1 0.0 6.3 3 2 1 4 4 4 0 ABC transporter SbcCD_C PF13558.6 EKE39849.1 - 0.13 12.5 0.0 0.81 10.0 0.0 2.2 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF3037 PF11236.8 EKE39849.1 - 0.15 12.5 0.2 0.15 12.5 0.2 5.4 5 2 3 8 8 8 0 Protein of unknown function (DUF3037) TLD PF07534.16 EKE39850.1 - 1.5e-07 31.7 0.4 2.2e-07 31.2 0.4 1.4 1 1 0 1 1 1 1 TLD Ras PF00071.22 EKE39851.1 - 3.3e-52 176.3 0.0 4e-52 176.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39851.1 - 1.2e-25 90.1 0.0 1.9e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39851.1 - 7.7e-12 45.0 0.0 1e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE39851.1 - 0.00011 21.7 0.0 0.00014 21.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE39851.1 - 0.005 16.4 0.0 0.022 14.3 0.0 1.8 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 EKE39851.1 - 0.026 14.0 0.1 0.066 12.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region TniB PF05621.11 EKE39851.1 - 0.067 12.6 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 EKE39851.1 - 0.1 12.3 0.2 1.4 8.7 0.2 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EKE39851.1 - 0.15 12.1 0.0 0.2 11.7 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Kri1_C PF12936.7 EKE39852.1 - 3.1e-20 72.1 2.2 3.1e-20 72.1 2.2 5.1 4 1 0 4 4 4 1 KRI1-like family C-terminal Kri1 PF05178.12 EKE39852.1 - 4.2e-08 33.7 33.5 4.2e-08 33.7 33.5 6.8 3 2 2 5 5 5 1 KRI1-like family DUF3333 PF11812.8 EKE39852.1 - 0.39 10.9 3.4 1.3 9.2 3.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3333) RNA_pol_Rpb4 PF03874.16 EKE39853.1 - 1.6e-06 28.5 1.9 2.1e-06 28.0 1.9 1.3 1 1 0 1 1 1 1 RNA polymerase Rpb4 Ribosomal_S28e PF01200.18 EKE39854.1 - 7.6e-29 99.5 1.4 8.9e-29 99.3 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S28e RhoGEF PF00621.20 EKE39855.1 - 4.3e-26 92.3 1.2 4.3e-26 92.3 1.2 3.0 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 EKE39855.1 - 0.039 14.5 2.1 0.24 11.9 0.7 2.6 2 0 0 2 2 2 0 PH domain HTH_7 PF02796.15 EKE39855.1 - 0.057 13.5 1.6 7.6 6.7 1.0 3.0 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase Aa_trans PF01490.18 EKE39856.1 - 1.4e-13 50.3 32.6 1.8e-13 50.0 32.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EKE39856.1 - 1.4e-05 24.4 18.3 1.4e-05 24.4 18.3 2.1 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family AA_permease_2 PF13520.6 EKE39856.1 - 0.0098 14.8 47.0 0.0024 16.8 35.4 2.7 1 1 1 2 2 2 1 Amino acid permease EVC2_like PF12297.8 EKE39856.1 - 0.23 10.1 0.5 1.2 7.8 0.0 2.0 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein Lipase_3 PF01764.25 EKE39857.1 - 5.5e-21 74.9 0.0 1.4e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EKE39857.1 - 2.8e-05 23.5 0.0 4.2e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 RPAP1_N PF08621.10 EKE39857.1 - 0.56 10.0 3.6 0.32 10.8 0.5 2.2 2 0 0 2 2 2 0 RPAP1-like, N-terminal FAM91_N PF14647.6 EKE39858.1 - 2.6e-26 92.6 6.6 3.1e-26 92.4 6.6 1.0 1 0 0 1 1 1 1 FAM91 N-terminus FAM91_C PF14648.6 EKE39859.1 - 6.1e-34 117.6 5.2 1.2e-30 106.7 2.0 2.1 1 1 1 2 2 2 2 FAM91 C-terminus TMEM154 PF15102.6 EKE39860.1 - 0.01 15.7 1.0 0.015 15.2 0.0 1.8 2 0 0 2 2 2 0 TMEM154 protein family Phage_Gp23 PF10669.9 EKE39860.1 - 0.026 14.9 1.9 4.7 7.6 0.2 2.4 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) LRRC37AB_C PF14914.6 EKE39860.1 - 0.028 14.3 1.0 0.13 12.2 0.3 2.2 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain FeoB_associated PF12669.7 EKE39860.1 - 0.78 10.2 0.1 0.78 10.2 0.1 2.1 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein RNA_pol_Rbc25 PF08292.12 EKE39862.1 - 3.8e-29 101.5 3.0 6.1e-21 75.0 0.2 2.3 1 1 1 2 2 2 2 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EKE39862.1 - 4.7e-06 26.9 0.0 9.5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DUF3464 PF11947.8 EKE39862.1 - 5.3 6.8 6.0 8.7 6.1 6.0 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 MIG-14_Wnt-bd PF06664.12 EKE39863.1 - 2.3e-13 50.0 48.2 2.3e-13 50.0 48.2 1.8 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion VMA21 PF09446.10 EKE39863.1 - 2.2 8.5 16.2 0.8 9.9 2.6 3.5 3 1 0 3 3 3 0 VMA21-like domain LIM PF00412.22 EKE39864.1 - 4.1e-12 46.1 36.9 4.7e-07 29.9 16.1 2.7 3 0 0 3 3 3 2 LIM domain LCAT PF02450.15 EKE39865.1 - 2.2e-35 122.6 3.0 1e-31 110.5 0.9 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 EKE39865.1 - 5.6e-05 23.0 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 EKE39865.1 - 0.00096 18.7 0.0 0.002 17.7 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EKE39865.1 - 0.0061 17.2 0.0 0.0083 16.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EKE39865.1 - 0.012 15.5 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase Lipase_3 PF01764.25 EKE39865.1 - 0.031 14.2 0.0 0.049 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF900 PF05990.12 EKE39865.1 - 0.031 13.8 0.0 0.069 12.6 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Glyco_hydro_77 PF02446.17 EKE39866.1 - 3e-50 171.4 0.0 3.5e-44 151.4 0.0 2.9 1 1 1 2 2 2 2 4-alpha-glucanotransferase CBM_20 PF00686.19 EKE39866.1 - 1.6e-11 43.9 0.2 5.8e-11 42.1 0.2 1.9 1 0 0 1 1 1 1 Starch binding domain Orf78 PF06024.12 EKE39867.1 - 0.037 14.3 0.0 0.075 13.3 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) TMEM154 PF15102.6 EKE39867.1 - 0.038 13.9 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family BatD PF13584.6 EKE39867.1 - 0.04 12.7 0.0 0.066 12.0 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance Ion_trans PF00520.31 EKE39867.1 - 0.068 12.4 0.5 0.2 10.9 0.5 1.7 1 0 0 1 1 1 0 Ion transport protein DUF3290 PF11694.8 EKE39867.1 - 0.55 10.2 4.0 0.2 11.6 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) Histone PF00125.24 EKE39868.1 - 1.4e-17 64.3 2.8 1.4e-17 64.3 2.8 2.3 1 1 1 2 2 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EKE39868.1 - 0.00083 19.5 1.3 0.0015 18.6 0.2 2.0 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EKE39868.1 - 0.045 14.1 0.3 0.045 14.1 0.3 2.1 2 0 0 2 2 2 0 CENP-S protein DUF948 PF06103.11 EKE39868.1 - 0.05 13.9 0.7 0.095 13.0 0.7 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) PA26 PF04636.13 EKE39868.1 - 0.17 10.8 2.7 0.22 10.4 2.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2730 PF10805.8 EKE39868.1 - 0.19 11.9 6.1 0.078 13.1 2.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) UPF0242 PF06785.11 EKE39868.1 - 1.1 9.4 10.6 1.5 8.9 10.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 EKE39868.1 - 2.3 8.7 7.2 5.2 7.6 7.2 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region TMPIT PF07851.13 EKE39868.1 - 5 6.3 7.0 6.1 6.0 7.0 1.2 1 0 0 1 1 1 0 TMPIT-like protein DivIC PF04977.15 EKE39868.1 - 6.9 6.5 8.0 0.5 10.2 0.6 2.3 2 0 0 2 2 2 0 Septum formation initiator Atg14 PF10186.9 EKE39868.1 - 9.6 5.2 11.9 12 4.8 11.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AA_kinase PF00696.28 EKE39869.1 - 1e-30 107.1 0.0 1.2e-30 107.0 0.0 1.0 1 0 0 1 1 1 1 Amino acid kinase family UQ_con PF00179.26 EKE39870.1 - 1.8e-38 131.3 0.1 2.1e-38 131.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EKE39870.1 - 0.01 15.7 0.1 0.018 14.9 0.1 1.4 1 1 0 1 1 1 0 UEV domain PTH2 PF01981.16 EKE39871.1 - 2.7e-21 76.0 0.2 3.6e-21 75.6 0.2 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 MMM1 PF10296.9 EKE39872.1 - 2.9e-07 29.8 0.1 5.1e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Peptidase_M4_C PF02868.15 EKE39872.1 - 0.036 13.9 0.0 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 Thermolysin metallopeptidase, alpha-helical domain eIF-1a PF01176.19 EKE39873.1 - 5.1e-19 67.9 0.2 7e-19 67.4 0.2 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Pkinase PF00069.25 EKE39874.1 - 2e-39 135.6 0.1 6.7e-39 133.8 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39874.1 - 1.3e-26 93.4 0.1 2.6e-26 92.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE39874.1 - 0.00074 18.9 0.0 0.0015 18.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EKE39874.1 - 0.063 13.2 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EKE39874.1 - 0.16 10.7 0.0 0.16 10.7 0.0 2.8 2 1 0 2 2 2 0 Fungal protein kinase YL1 PF05764.13 EKE39875.1 - 0.075 13.1 11.7 0.1 12.7 11.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DUF1848 PF08902.11 EKE39875.1 - 0.093 12.4 3.1 0.12 12.1 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) DUF763 PF05559.11 EKE39875.1 - 0.2 10.8 4.7 0.22 10.6 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF763) RPN6_C_helix PF18503.1 EKE39875.1 - 0.25 11.1 1.3 20 5.0 0.1 3.0 3 0 0 3 3 3 0 26S proteasome subunit RPN6 C-terminal helix domain HU-CCDC81_bac_2 PF18175.1 EKE39875.1 - 0.37 10.7 9.0 3.8 7.4 0.4 2.9 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 DUF5340 PF17275.2 EKE39875.1 - 4 7.7 8.0 1.8 8.8 4.4 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5340) LMBR1 PF04791.16 EKE39875.1 - 6.2 5.6 8.2 7.4 5.3 8.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PCYCGC PF13798.6 EKE39876.1 - 0.0023 17.8 0.1 0.0048 16.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function with PCYCGC motif zf-C3HC4_3 PF13920.6 EKE39877.1 - 8e-10 38.4 6.1 1.2e-09 37.9 6.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EKE39877.1 - 1.7e-08 34.3 9.0 2.6e-08 33.7 9.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EKE39877.1 - 6.4e-08 32.3 6.8 9.5e-08 31.8 6.8 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EKE39877.1 - 2.9e-07 30.4 5.7 2.9e-07 30.4 5.7 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EKE39877.1 - 1.2e-06 28.2 11.2 1.9e-06 27.6 11.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE39877.1 - 4.9e-06 26.3 10.6 9.2e-06 25.4 10.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE39877.1 - 5.9e-06 26.5 9.1 9.3e-06 25.9 9.1 1.3 1 0 0 1 1 1 1 Ring finger domain DUF997 PF06196.12 EKE39877.1 - 0.00025 21.0 0.6 0.00038 20.4 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF997) zf-C3HC4_4 PF15227.6 EKE39877.1 - 0.00045 20.3 8.1 0.002 18.3 8.3 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EKE39877.1 - 0.0051 16.7 4.5 0.0082 16.0 4.5 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 EKE39877.1 - 0.0086 16.2 3.1 0.013 15.6 3.1 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 TMEM117 PF15113.6 EKE39877.1 - 0.01 14.8 0.1 0.012 14.6 0.1 1.1 1 0 0 1 1 1 0 TMEM117 protein family zf-RING_11 PF17123.5 EKE39877.1 - 0.018 14.8 5.5 0.051 13.3 5.5 1.8 1 0 0 1 1 1 0 RING-like zinc finger Rtf2 PF04641.12 EKE39877.1 - 0.06 12.7 0.0 0.07 12.5 0.0 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger NOB1_Zn_bind PF08772.11 EKE39877.1 - 0.067 13.4 4.1 0.51 10.5 4.1 2.0 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like DUF1272 PF06906.11 EKE39877.1 - 0.13 12.3 6.8 0.22 11.6 6.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-rbx1 PF12678.7 EKE39877.1 - 0.13 12.5 6.9 0.28 11.5 6.9 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ribbon_3 PF13248.6 EKE39877.1 - 0.38 10.2 0.1 0.38 10.2 0.1 2.5 2 1 0 2 2 2 0 zinc-ribbon domain FANCL_C PF11793.8 EKE39877.1 - 7.5 6.8 10.3 2.5 8.4 1.1 2.8 1 1 1 2 2 2 0 FANCL C-terminal domain Pkinase_Tyr PF07714.17 EKE39878.1 - 3.4e-52 177.3 0.0 5.6e-52 176.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE39878.1 - 5.7e-42 143.9 0.0 9.7e-42 143.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EKE39878.1 - 0.017 14.5 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4987 PF16377.5 EKE39878.1 - 0.022 14.9 2.4 3.8 7.7 1.5 2.5 2 0 0 2 2 2 0 Domain of unknown function EOS1 PF12326.8 EKE39878.1 - 0.088 12.7 4.8 0.072 13.0 1.3 2.5 2 2 0 2 2 2 0 N-glycosylation protein XPC-binding PF09280.11 EKE39878.1 - 0.1 12.4 0.2 0.27 11.0 0.2 1.7 1 0 0 1 1 1 0 XPC-binding domain MTBP_C PF14920.6 EKE39878.1 - 0.55 9.9 9.0 1.2 8.8 9.0 1.5 1 0 0 1 1 1 0 MDM2-binding DUF1635 PF07795.11 EKE39878.1 - 2.8 7.7 7.5 9.5 6.0 7.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) TAFII55_N PF04658.13 EKE39883.1 - 1.7e-22 79.9 0.2 5.4e-22 78.2 0.2 1.7 1 1 0 1 1 1 1 TAFII55 protein conserved region DUF3599 PF12206.8 EKE39884.1 - 0.11 12.8 4.1 3.9 7.9 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3599) Copine PF07002.16 EKE39885.1 - 3.3e-62 209.8 0.1 6.5e-62 208.8 0.0 1.5 2 0 0 2 2 2 1 Copine vWA-TerF-like PF10138.9 EKE39885.1 - 4.8e-09 36.6 0.0 6.7e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EKE39885.1 - 0.029 14.6 0.1 0.059 13.6 0.0 1.6 2 0 0 2 2 2 0 von Willebrand factor type A domain DnaJ_C PF01556.18 EKE39886.1 - 1.4e-15 57.6 6.4 2.5e-15 56.9 6.4 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain Peptidase_M75 PF09375.10 EKE39886.1 - 0.18 11.2 0.1 0.3 10.5 0.1 1.2 1 0 0 1 1 1 0 Imelysin Syntaxin PF00804.25 EKE39887.1 - 0.0051 16.5 5.6 0.0085 15.8 5.6 1.4 1 0 0 1 1 1 1 Syntaxin Arena_ncap_C PF17290.2 EKE39887.1 - 0.0055 16.1 0.7 0.0093 15.3 0.7 1.5 1 1 0 1 1 1 1 Arenavirus nucleocapsid C-terminal domain Shugoshin_N PF07558.11 EKE39887.1 - 0.034 14.0 1.2 0.034 14.0 1.2 2.3 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region Paralemmin PF03285.15 EKE39887.1 - 0.075 12.6 9.3 0.11 12.1 9.3 1.2 1 0 0 1 1 1 0 Paralemmin DivIC PF04977.15 EKE39887.1 - 0.61 9.9 13.3 0.15 11.8 6.2 2.6 1 1 1 2 2 2 0 Septum formation initiator LRR_4 PF12799.7 EKE39888.1 - 0.29 11.6 3.4 3.7 8.1 0.0 3.7 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) RNA_pol_Rpb1_5 PF04998.17 EKE39890.1 - 2.8e-82 276.1 0.2 1e-81 274.3 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EKE39890.1 - 4.9e-69 231.8 0.1 1.4e-68 230.3 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 EKE39890.1 - 7.9e-69 232.4 8.2 1.8e-68 231.2 8.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_6 PF04992.14 EKE39890.1 - 1.8e-44 151.9 1.5 1.8e-44 151.9 1.5 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EKE39890.1 - 6.7e-37 126.8 0.1 2.3e-36 125.1 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EKE39890.1 - 1.6e-24 85.9 0.0 7e-24 83.9 0.0 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_7 PF04990.12 EKE39890.1 - 4.6e-14 52.6 1.8 1.1e-13 51.3 1.8 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 HMG_box PF00505.19 EKE39891.1 - 5e-06 26.8 0.8 5.9e-06 26.6 0.8 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EKE39891.1 - 1.2e-05 25.8 0.8 1.4e-05 25.5 0.8 1.2 1 0 0 1 1 1 1 HMG-box domain Perilipin PF03036.16 EKE39892.1 - 0.018 14.1 0.8 0.019 14.0 0.8 1.1 1 0 0 1 1 1 0 Perilipin family DUF4940 PF16298.5 EKE39892.1 - 0.033 13.9 1.0 0.053 13.2 0.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4940) Fucose_iso_N2 PF07882.12 EKE39892.1 - 0.099 12.2 3.4 0.12 12.0 3.4 1.1 1 0 0 1 1 1 0 L-fucose isomerase, second N-terminal domain HMG_box PF00505.19 EKE39892.1 - 0.13 12.7 7.1 0.8 10.2 1.9 3.0 2 2 1 3 3 3 0 HMG (high mobility group) box RRM_1 PF00076.22 EKE39893.1 - 1.2e-46 156.4 11.8 8.3e-16 57.6 1.3 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EKE39893.1 - 1.6e-06 28.1 1.1 0.056 13.6 0.0 2.9 3 1 0 3 3 3 2 RNA recognition motif Limkain-b1 PF11608.8 EKE39893.1 - 4.7e-06 26.6 7.4 0.04 14.0 0.3 4.6 4 1 0 4 4 4 2 Limkain b1 RRM_Rrp7 PF17799.1 EKE39893.1 - 1.4e-05 24.9 5.2 0.016 15.0 0.7 2.4 2 0 0 2 2 2 2 Rrp7 RRM-like N-terminal domain RRM_occluded PF16842.5 EKE39893.1 - 4.6e-05 23.2 2.3 0.26 11.2 0.0 3.5 3 1 0 3 3 3 2 Occluded RNA-recognition motif zinc_ribbon_11 PF11682.8 EKE39893.1 - 0.0013 18.7 0.3 0.36 10.9 0.1 2.5 2 0 0 2 2 2 1 Probable zinc-ribbon FAM91_C PF14648.6 EKE39893.1 - 0.0037 16.2 8.5 0.019 13.8 0.9 2.1 1 1 1 2 2 2 2 FAM91 C-terminus SET_assoc PF11767.8 EKE39893.1 - 0.0065 16.1 0.5 0.18 11.5 0.0 3.4 4 1 0 4 4 4 1 Histone lysine methyltransferase SET associated DUF4944 PF16302.5 EKE39893.1 - 0.0074 16.4 4.1 0.79 9.8 0.3 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF4944) DUF1811 PF08838.10 EKE39893.1 - 0.027 14.7 3.7 0.59 10.4 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) CBM_X2 PF03442.14 EKE39893.1 - 0.1 12.7 3.0 8.2 6.6 0.1 2.9 3 0 0 3 3 3 0 Carbohydrate binding domain X2 Lactamase_B_3 PF13483.6 EKE39893.1 - 0.2 11.6 0.6 17 5.3 0.0 2.5 1 1 1 2 2 2 0 Beta-lactamase superfamily domain DUF4358 PF14270.6 EKE39893.1 - 0.97 9.8 6.4 1.2 9.4 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4358) DbpA PF03880.15 EKE39893.1 - 1.5 8.9 6.4 7.9 6.6 0.3 3.5 4 0 0 4 4 4 0 DbpA RNA binding domain Metallophos PF00149.28 EKE39894.1 - 7.9e-11 42.8 0.2 1.2e-10 42.3 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE39894.1 - 5.7e-07 29.9 0.0 0.00018 21.7 0.0 3.0 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain DeoC PF01791.9 EKE39895.1 - 1.3e-18 67.5 5.8 1.5e-18 67.3 5.8 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase NanE PF04131.14 EKE39895.1 - 0.0068 15.6 3.0 0.011 14.9 3.0 1.4 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase DHO_dh PF01180.21 EKE39895.1 - 0.032 13.4 2.9 0.091 11.9 0.4 2.2 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase DUF1513 PF07433.11 EKE39895.1 - 0.038 13.1 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) TLD PF07534.16 EKE39896.1 - 1e-08 35.5 2.3 2e-08 34.5 2.3 1.5 1 0 0 1 1 1 1 TLD ABC_transp_aux PF09822.9 EKE39896.1 - 0.0016 17.9 5.8 0.0016 17.9 5.8 1.6 1 1 0 1 1 1 1 ABC-type uncharacterized transport system DUF763 PF05559.11 EKE39896.1 - 0.31 10.2 4.0 0.49 9.5 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF763) Exonuc_VII_L PF02601.15 EKE39896.1 - 2.2 7.7 9.5 3.5 7.1 9.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.12 EKE39896.1 - 9.2 6.3 9.4 7.2 6.6 2.5 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Beach PF02138.18 EKE39897.1 - 2.8e-73 246.7 1.9 5.2e-73 245.8 1.9 1.5 1 0 0 1 1 1 1 Beige/BEACH domain Acyl_transf_1 PF00698.21 EKE39899.1 - 0.0019 17.8 0.1 0.0031 17.1 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain DUF2913 PF11140.8 EKE39899.1 - 0.05 13.3 0.3 0.53 10.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2913) HHH_2 PF12826.7 EKE39899.1 - 0.11 12.6 0.0 3.2 7.9 0.0 2.8 2 0 0 2 2 2 0 Helix-hairpin-helix motif Glyco_hydro38C2 PF17677.1 EKE39899.1 - 0.17 12.0 2.8 0.48 10.6 2.8 1.8 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal beta sandwich domain CRS1_YhbY PF01985.21 EKE39899.1 - 0.28 11.4 5.5 6.8 6.9 0.0 2.7 2 1 1 3 3 3 0 CRS1 / YhbY (CRM) domain Pkinase_Tyr PF07714.17 EKE39900.1 - 6e-54 183.0 0.4 6.9e-54 182.8 0.4 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE39900.1 - 1.4e-51 175.4 0.7 1.8e-51 175.0 0.7 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE39900.1 - 2.1e-07 30.1 0.1 2.3e-07 29.9 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE39900.1 - 0.0013 18.2 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EKE39900.1 - 0.031 13.9 0.1 0.11 12.1 0.1 2.0 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Sec1 PF00995.23 EKE39901.1 - 1.3e-34 120.4 2.8 1.7e-34 120.0 2.8 1.1 1 0 0 1 1 1 1 Sec1 family HAD_2 PF13419.6 EKE39902.1 - 3.4e-25 89.2 0.5 4.3e-25 88.8 0.5 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKE39902.1 - 1.3e-11 45.2 0.0 1.1e-10 42.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EKE39902.1 - 1.5e-10 41.8 0.0 2e-10 41.4 0.0 1.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EKE39902.1 - 0.002 18.2 0.0 0.46 10.6 0.0 3.0 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EKE39902.1 - 0.018 14.4 1.0 0.071 12.5 1.0 1.8 1 1 0 1 1 1 0 Putative Phosphatase Hydrolase_like PF13242.6 EKE39902.1 - 0.031 14.3 0.0 0.052 13.6 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Acid_PPase PF12689.7 EKE39902.1 - 0.13 12.1 0.4 0.35 10.7 0.4 2.0 1 1 0 1 1 1 0 Acid Phosphatase Hydrolase_3 PF08282.12 EKE39902.1 - 0.21 11.3 2.2 0.84 9.3 0.0 2.5 1 1 2 3 3 3 0 haloacid dehalogenase-like hydrolase ORC2 PF04084.14 EKE39903.1 - 0.00045 19.2 0.2 0.00072 18.6 0.2 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 HTH_20 PF12840.7 EKE39903.1 - 0.039 14.0 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Ras PF00071.22 EKE39904.1 - 4.1e-54 182.6 0.7 4.9e-54 182.3 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39904.1 - 1.4e-26 93.0 0.0 2.4e-26 92.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39904.1 - 6.2e-10 38.8 0.0 8.1e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE39904.1 - 1.4e-06 28.4 0.8 0.058 13.3 0.2 3.0 1 1 1 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE39904.1 - 1.6e-06 28.2 0.0 2.9e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE39904.1 - 1.3e-05 24.9 0.1 0.0012 18.4 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE39904.1 - 8.4e-05 22.0 0.1 0.00011 21.7 0.1 1.2 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EKE39904.1 - 0.00022 20.7 1.5 0.00074 19.0 0.0 2.1 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EKE39904.1 - 0.00043 20.0 0.1 0.011 15.4 0.1 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 EKE39904.1 - 0.0026 18.0 0.1 0.018 15.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EKE39904.1 - 0.0078 16.6 0.1 0.017 15.5 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain 6PF2K PF01591.18 EKE39904.1 - 0.022 14.0 0.1 0.93 8.7 0.1 2.3 1 1 0 1 1 1 0 6-phosphofructo-2-kinase AAA_22 PF13401.6 EKE39904.1 - 0.033 14.5 0.0 0.57 10.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EKE39904.1 - 0.037 14.6 0.0 0.076 13.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EKE39904.1 - 0.038 13.7 0.0 0.47 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 EKE39904.1 - 0.041 13.2 0.1 0.041 13.2 0.1 1.5 2 0 0 2 2 2 0 Septin NB-ARC PF00931.22 EKE39904.1 - 0.05 12.8 0.1 1 8.5 0.1 2.1 1 1 0 1 1 1 0 NB-ARC domain AAA_33 PF13671.6 EKE39904.1 - 0.075 13.2 0.0 0.14 12.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKE39904.1 - 0.089 12.3 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region zf-ANAPC11 PF12861.7 EKE39905.1 - 0.24 11.5 7.4 0.43 10.6 7.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-4CXXC_R1 PF10497.9 EKE39905.1 - 5.5 7.3 20.4 13 6.1 20.4 1.6 1 1 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 GRAM PF02893.20 EKE39906.1 - 1.2e-07 31.6 0.5 4.3e-07 29.8 0.5 2.0 1 1 0 1 1 1 1 GRAM domain PRKG1_interact PF15898.5 EKE39907.1 - 0.01 16.7 6.5 0.01 16.7 6.5 4.1 3 2 2 5 5 5 0 cGMP-dependent protein kinase interacting domain DUF3906 PF13046.6 EKE39907.1 - 0.13 12.4 1.2 1.2 9.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3906) MbeD_MobD PF04899.12 EKE39907.1 - 0.46 10.6 4.2 0.81 9.9 0.2 2.8 3 0 0 3 3 3 0 MbeD/MobD like IMUP PF15761.5 EKE39907.1 - 1 10.1 4.3 1.5 9.5 1.7 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein zf-C2HC5 PF06221.13 EKE39908.1 - 4.2e-10 39.4 4.6 6.3e-10 38.9 4.6 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type DUF4833 PF16117.5 EKE39908.1 - 0.067 13.2 0.1 0.091 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4833) zf-ACC PF17848.1 EKE39909.1 - 0.017 15.2 2.6 5 7.3 0.1 3.2 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain Yippee-Mis18 PF03226.14 EKE39909.1 - 0.029 14.6 1.6 0.072 13.3 1.6 1.6 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HECT_2 PF09814.9 EKE39909.1 - 0.091 11.6 2.2 0.56 9.0 0.1 2.0 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding SelR PF01641.18 EKE39909.1 - 0.11 12.6 0.2 0.42 10.7 0.2 1.8 1 1 0 1 1 1 0 SelR domain zinc_ribbon_4 PF13717.6 EKE39909.1 - 0.75 9.8 4.5 7.5 6.6 0.0 2.6 3 0 0 3 3 3 0 zinc-ribbon domain zf-LSD1 PF06943.12 EKE39909.1 - 1.6 8.7 4.1 9.3 6.2 0.4 2.3 2 0 0 2 2 2 0 LSD1 zinc finger Phosducin PF02114.16 EKE39910.1 - 8.8e-17 60.9 0.4 1e-16 60.7 0.4 1.2 1 0 0 1 1 1 1 Phosducin Adaptin_binding PF10199.9 EKE39910.1 - 0.0046 17.5 0.0 0.0091 16.6 0.0 1.4 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 EF-1_beta_acid PF10587.9 EKE39910.1 - 0.017 15.5 6.1 0.017 15.5 6.1 2.5 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region SelB-wing_1 PF09105.10 EKE39910.1 - 0.12 12.4 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Elongation factor SelB, winged helix DUF445 PF04286.12 EKE39910.1 - 0.33 10.7 4.0 0.43 10.3 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) TMEM154 PF15102.6 EKE39911.1 - 4.1e-05 23.5 8.7 0.00013 21.9 8.7 1.8 1 1 0 1 1 1 1 TMEM154 protein family SAPS PF04499.15 EKE39911.1 - 0.0059 15.5 0.8 0.0089 14.9 0.8 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Podoplanin PF05808.11 EKE39911.1 - 0.0064 16.6 0.2 0.012 15.7 0.2 1.4 1 0 0 1 1 1 1 Podoplanin ABC2_membrane_3 PF12698.7 EKE39911.1 - 0.0086 15.2 4.4 0.012 14.8 4.4 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF2207 PF09972.9 EKE39911.1 - 0.012 14.4 0.0 0.017 14.0 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SDA1 PF05285.12 EKE39911.1 - 0.014 14.9 8.2 0.02 14.3 8.2 1.1 1 0 0 1 1 1 0 SDA1 DUF1180 PF06679.12 EKE39911.1 - 0.015 15.7 0.9 0.027 14.9 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) BatD PF13584.6 EKE39911.1 - 0.019 13.8 0.0 0.025 13.4 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance DUF2970 PF11174.8 EKE39911.1 - 0.021 14.6 0.3 0.034 14.0 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) DUF5305 PF17231.2 EKE39911.1 - 0.033 13.6 0.1 0.048 13.0 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF5385 PF17359.2 EKE39911.1 - 0.037 13.6 1.3 0.068 12.7 1.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Orf78 PF06024.12 EKE39911.1 - 0.076 13.3 12.0 2.9 8.2 12.0 2.4 1 1 0 1 1 1 0 Orf78 (ac78) Raftlin PF15250.6 EKE39911.1 - 0.12 11.1 3.3 0.21 10.3 3.3 1.3 1 0 0 1 1 1 0 Raftlin AIF_C PF14721.6 EKE39911.1 - 0.12 12.7 4.2 0.24 11.8 3.1 1.9 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Kei1 PF08552.11 EKE39911.1 - 0.26 11.1 0.7 0.51 10.2 0.7 1.5 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF5383 PF17355.2 EKE39911.1 - 0.3 11.5 1.1 0.55 10.6 0.4 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5383) Pilin_N PF07790.11 EKE39911.1 - 0.81 10.7 2.3 2.6 9.0 2.3 1.8 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal Menin PF05053.13 EKE39911.1 - 1.2 7.4 9.2 1.8 6.9 9.2 1.1 1 0 0 1 1 1 0 Menin Neur_chan_memb PF02932.16 EKE39911.1 - 1.5 8.8 3.9 6.7 6.7 4.3 1.7 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 EKE39911.1 - 3.3 6.6 5.9 4.8 6.1 5.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PNISR PF15996.5 EKE39911.1 - 3.7 7.8 8.4 5.8 7.1 8.4 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Apt1 PF10351.9 EKE39911.1 - 4 6.2 24.8 5.7 5.7 24.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CDC45 PF02724.14 EKE39911.1 - 5.4 5.2 11.9 7.9 4.6 11.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EKE39911.1 - 7.6 4.6 16.9 10 4.2 16.9 1.0 1 0 0 1 1 1 0 Nop14-like family Syndecan PF01034.20 EKE39911.1 - 7.9 6.5 7.2 1.2 9.1 2.6 2.0 2 0 0 2 2 1 0 Syndecan domain zf-UBR PF02207.20 EKE39912.1 - 2.2e-15 56.6 19.5 2.2e-15 56.6 19.5 3.3 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) zf-RING_5 PF14634.6 EKE39912.1 - 7.4e-06 25.8 2.2 7.4e-06 25.8 2.2 4.2 4 0 0 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.6 EKE39912.1 - 2.9e-05 24.3 2.8 2.9e-05 24.3 2.8 4.7 5 1 0 5 5 5 1 Ring finger domain zf-rbx1 PF12678.7 EKE39912.1 - 0.00041 20.6 1.1 0.00041 20.6 1.1 3.2 4 0 0 4 4 4 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EKE39912.1 - 0.00097 19.0 1.0 0.00097 19.0 1.0 5.3 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE39912.1 - 0.001 18.9 3.9 0.001 18.9 3.9 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Polyoma_coat2 PF00761.20 EKE39912.1 - 0.0027 17.5 0.0 0.0047 16.7 0.0 1.3 1 0 0 1 1 1 1 Polyomavirus coat protein CDC50 PF03381.15 EKE39913.1 - 3.1e-74 250.0 2.7 3.6e-74 249.8 2.0 1.5 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family UPF0060 PF02694.15 EKE39913.1 - 0.038 14.2 0.6 0.1 12.9 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family CUB_2 PF02408.20 EKE39913.1 - 0.11 12.2 3.8 0.075 12.8 1.8 2.0 2 1 0 2 2 2 0 CUB-like domain DUF3185 PF11381.8 EKE39913.1 - 1.2 9.2 5.8 0.7 9.9 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) CAP_C PF08603.11 EKE39914.1 - 0.77 9.4 4.7 0.4 10.3 0.4 2.3 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) C terminal RNB PF00773.19 EKE39915.1 - 2.7e-16 59.8 1.1 1.6e-14 54.0 0.9 2.6 2 1 0 2 2 2 2 RNB domain HSP90 PF00183.18 EKE39916.1 - 6e-144 480.8 27.2 8e-144 480.4 27.2 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.6 EKE39916.1 - 9.3e-12 44.9 0.1 9.3e-12 44.9 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EKE39916.1 - 2.3e-09 37.8 0.1 5e-09 36.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Polyketide_cyc PF03364.20 EKE39916.1 - 0.16 12.2 0.8 0.42 10.8 0.8 1.7 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Fcf1 PF04900.12 EKE39917.1 - 2.2e-05 24.8 1.4 0.00012 22.4 1.4 2.2 1 1 0 1 1 1 1 Fcf1 DUF4107 PF13389.6 EKE39917.1 - 0.025 14.7 0.7 0.085 13.0 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4107) DUF5624 PF18538.1 EKE39918.1 - 0.11 12.7 0.2 2.9 8.0 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5624) TrbM PF07424.11 EKE39918.1 - 0.49 10.3 2.4 3.7 7.5 0.3 2.1 1 1 1 2 2 2 0 TrbM Fib_alpha PF08702.10 EKE39918.1 - 0.55 10.4 14.6 0.22 11.7 6.2 2.1 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family CENP-H PF05837.12 EKE39918.1 - 2 8.9 17.1 5.8 7.4 7.0 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF4446 PF14584.6 EKE39918.1 - 2 8.4 15.2 3.3 7.7 2.6 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) CENP-Q PF13094.6 EKE39918.1 - 3 8.0 9.1 13 5.9 9.1 2.2 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit MCPsignal PF00015.21 EKE39918.1 - 7.3 6.4 9.9 7.6 6.3 4.5 2.4 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Pkinase PF00069.25 EKE39919.1 - 4.7e-48 163.8 0.0 8.9e-48 162.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.12 EKE39919.1 - 6.2e-33 113.7 0.2 1.4e-32 112.5 0.2 1.6 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 EKE39919.1 - 1.7e-30 106.1 0.0 2.7e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE39919.1 - 2e-05 24.1 0.0 4.5e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EKE39919.1 - 0.00089 18.3 0.2 0.0017 17.3 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EKE39919.1 - 0.0022 17.9 0.1 0.005 16.8 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EKE39919.1 - 0.0066 15.8 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKE39919.1 - 0.065 12.0 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase PQQ_2 PF13360.6 EKE39919.1 - 0.073 12.6 0.0 3.7 7.1 0.0 2.3 2 0 0 2 2 2 0 PQQ-like domain adh_short PF00106.25 EKE39921.1 - 1.9e-20 73.2 0.5 2.5e-19 69.5 0.5 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EKE39921.1 - 2.5e-08 33.8 0.1 5.3e-08 32.7 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EKE39921.1 - 1.1e-07 31.5 0.0 1.8e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EKE39921.1 - 0.003 17.5 0.0 0.0045 16.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EKE39921.1 - 0.03 14.3 1.7 0.18 11.7 1.7 2.1 1 1 0 1 1 1 0 KR domain Nodulin_late PF07127.11 EKE39921.1 - 0.1 13.0 0.4 0.1 13.0 0.4 2.3 2 0 0 2 2 2 0 Late nodulin protein RmlD_sub_bind PF04321.17 EKE39921.1 - 0.15 11.1 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain JAB PF01398.21 EKE39922.1 - 1.3e-32 112.3 0.1 2.8e-32 111.2 0.1 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EKE39922.1 - 9.2e-09 35.1 0.0 3e-08 33.5 0.0 1.8 1 1 1 2 2 2 1 Prokaryotic homologs of the JAB domain MitMem_reg PF13012.6 EKE39922.1 - 1.9e-08 34.7 0.3 5.1e-08 33.3 0.3 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 EKE39922.1 - 0.0027 17.8 0.3 0.0074 16.3 0.3 1.9 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0172) CH PF00307.31 EKE39923.1 - 2e-15 56.9 0.2 3.2e-06 27.3 0.0 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain PH PF00169.29 EKE39923.1 - 0.0035 17.8 0.2 0.0095 16.4 0.2 1.8 1 0 0 1 1 1 1 PH domain Ndc1_Nup PF09531.10 EKE39923.1 - 0.014 14.1 1.2 0.02 13.6 1.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PH_11 PF15413.6 EKE39923.1 - 0.2 12.1 0.9 0.77 10.2 0.2 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain DnaJ PF00226.31 EKE39924.1 - 3.4e-24 84.7 0.8 9.6e-24 83.3 0.8 1.9 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 EKE39924.1 - 2.1e-09 37.4 8.4 5.1e-09 36.2 8.4 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EKE39924.1 - 4.1e-09 36.5 6.1 7.8e-09 35.6 6.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EKE39924.1 - 0.00031 21.0 6.4 0.00067 20.0 5.4 2.2 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EKE39924.1 - 0.011 16.5 1.5 0.03 15.2 1.5 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger RPT PF13446.6 EKE39924.1 - 0.02 14.8 0.4 0.46 10.4 0.0 2.6 2 0 0 2 2 2 0 A repeated domain in UCH-protein zf-C2H2 PF00096.26 EKE39924.1 - 0.047 14.2 2.2 0.096 13.2 2.2 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EKE39924.1 - 1.4 9.0 3.7 3.6 7.7 3.7 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger Spore_III_AB PF09548.10 EKE39924.1 - 2.4 8.3 11.0 0.6 10.2 6.7 2.1 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Atg14 PF10186.9 EKE39924.1 - 3.8 6.5 16.6 6.3 5.8 16.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nitroreductase PF00881.24 EKE39925.1 - 5.2e-30 104.7 0.0 6.2e-30 104.5 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 EKE39925.1 - 3.1e-09 36.7 0.3 0.0023 17.5 0.0 2.9 1 1 1 2 2 2 2 Putative TM nitroreductase partial_CstF PF15861.5 EKE39925.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain UPF0203 PF05254.12 EKE39926.1 - 0.1 12.8 0.2 0.24 11.7 0.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0203) vATP-synt_AC39 PF01992.16 EKE39927.1 - 4.7e-102 341.9 3.1 5.3e-102 341.8 3.1 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit DUF4226 PF10774.9 EKE39927.1 - 0.022 15.0 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4226) Ras PF00071.22 EKE39928.1 - 1.5e-46 158.0 1.2 1.7e-46 157.8 1.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39928.1 - 2e-28 99.0 1.0 2.6e-28 98.6 1.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39928.1 - 4.2e-11 42.6 0.1 5.2e-11 42.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE39928.1 - 2.5e-06 27.1 0.2 3.3e-06 26.6 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE39928.1 - 4.9e-06 26.5 0.2 0.071 13.0 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EKE39928.1 - 9.5e-05 21.9 0.2 0.0001 21.7 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE39928.1 - 0.00018 21.1 0.7 0.006 16.1 0.7 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 EKE39928.1 - 0.00025 20.5 0.0 0.0015 18.0 0.0 2.0 2 0 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 EKE39928.1 - 0.00079 19.7 0.0 0.003 17.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EKE39928.1 - 0.00085 19.2 0.7 0.014 15.1 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EKE39928.1 - 0.00089 19.3 0.4 0.0015 18.6 0.4 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EKE39928.1 - 0.0011 18.3 0.1 0.002 17.5 0.1 1.4 1 0 0 1 1 1 1 Septin SRP54 PF00448.22 EKE39928.1 - 0.0029 17.2 0.4 0.58 9.7 0.1 2.4 1 1 1 2 2 2 2 SRP54-type protein, GTPase domain IIGP PF05049.13 EKE39928.1 - 0.0033 16.5 0.1 0.0046 16.1 0.1 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_7 PF12775.7 EKE39928.1 - 0.0036 16.8 0.1 0.0075 15.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 EKE39928.1 - 0.0066 16.8 0.0 0.0094 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain G-alpha PF00503.20 EKE39928.1 - 0.012 14.9 0.8 0.17 11.0 0.0 2.4 1 1 1 2 2 2 0 G-protein alpha subunit Zeta_toxin PF06414.12 EKE39928.1 - 0.016 14.5 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 EKE39928.1 - 0.019 14.7 0.6 0.036 13.8 0.6 1.6 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EKE39928.1 - 0.036 13.4 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 KaiC NTPase_1 PF03266.15 EKE39928.1 - 0.058 13.3 0.2 0.096 12.6 0.2 1.4 1 0 0 1 1 1 0 NTPase DLIC PF05783.11 EKE39928.1 - 0.12 11.2 0.5 2.3 7.0 0.2 2.1 1 1 0 2 2 2 0 Dynein light intermediate chain (DLIC) GalKase_gal_bdg PF10509.9 EKE39929.1 - 3.6e-20 71.3 0.1 6.6e-20 70.4 0.1 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 EKE39929.1 - 3.7e-12 46.4 0.0 6.7e-11 42.4 0.0 2.4 2 0 0 2 2 2 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 EKE39929.1 - 9.6e-10 38.6 0.2 2e-09 37.6 0.2 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain CsgA PF17334.2 EKE39929.1 - 0.00061 20.5 0.3 0.0017 19.0 0.3 1.7 1 0 0 1 1 1 1 Minor curli fiber component A Matrix PF00661.21 EKE39929.1 - 0.021 13.5 0.0 0.034 12.9 0.0 1.2 1 0 0 1 1 1 0 Viral matrix protein DUF2408 PF10303.9 EKE39929.1 - 0.097 13.2 0.6 0.28 11.8 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) Aldose_epim PF01263.20 EKE39930.1 - 3.5e-79 266.2 1.0 3.9e-79 266.1 1.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase LRR_5 PF13306.6 EKE39931.1 - 1.6e-55 186.5 50.4 8.3e-30 103.4 8.3 6.4 3 3 3 6 6 6 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE39931.1 - 2.6e-06 27.1 0.1 0.27 11.0 0.0 3.9 2 1 1 3 3 3 3 Leucine rich repeat CH PF00307.31 EKE39932.1 - 2.5e-21 75.9 8.5 9.7e-11 41.8 0.0 3.6 3 0 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EKE39932.1 - 3.9e-07 29.8 0.0 0.03 14.2 0.0 3.0 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 EKE39932.1 - 0.0011 19.0 4.7 0.0014 18.7 0.1 3.6 4 0 0 4 4 4 1 CH-like domain in sperm protein HEAT PF02985.22 EKE39933.1 - 1.1e-10 40.8 5.0 0.0073 16.5 0.0 9.1 10 0 0 10 10 10 1 HEAT repeat HEAT_2 PF13646.6 EKE39933.1 - 2.3e-07 31.1 0.0 3.7 8.0 0.0 6.7 6 1 1 7 7 7 1 HEAT repeats IBN_N PF03810.19 EKE39933.1 - 4e-07 29.8 5.0 1.7e-06 27.8 0.3 4.2 4 0 0 4 4 3 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EKE39933.1 - 0.00011 22.7 6.9 28 5.4 0.2 6.4 4 2 2 6 6 6 0 Vacuolar 14 Fab1-binding region Nipped-B_C PF12830.7 EKE39933.1 - 0.00043 20.3 0.6 3.1 7.7 0.0 4.4 3 1 1 4 4 4 1 Sister chromatid cohesion C-terminus HEAT_EZ PF13513.6 EKE39933.1 - 0.0012 19.3 5.5 57 4.4 0.0 7.5 8 1 1 9 9 9 0 HEAT-like repeat Condensin2nSMC PF12422.8 EKE39933.1 - 0.0054 16.9 2.5 15 5.7 0.2 5.0 4 2 0 4 4 4 0 Condensin II non structural maintenance of chromosomes subunit IFRD PF05004.13 EKE39933.1 - 0.012 14.7 7.5 0.12 11.5 0.8 3.5 2 2 1 3 3 3 0 Interferon-related developmental regulator (IFRD) DUF3437 PF11919.8 EKE39933.1 - 0.038 13.9 0.3 9.1 6.3 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF3437) Arm PF00514.23 EKE39933.1 - 0.088 12.9 14.1 6.8 6.9 0.0 7.0 8 0 0 8 8 7 0 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EKE39933.1 - 0.12 12.4 0.1 0.12 12.4 0.1 5.4 4 1 2 6 6 6 0 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EKE39933.1 - 1.4 9.1 5.4 12 6.1 0.2 4.7 4 2 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 SPAM PF02090.15 EKE39934.1 - 0.01 15.6 3.5 0.01 15.6 3.5 1.4 2 0 0 2 2 2 0 Salmonella surface presentation of antigen gene type M protein FAD_binding_5 PF00941.21 EKE39934.1 - 0.026 14.2 0.0 0.034 13.9 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain in molybdopterin dehydrogenase Bacillus_HBL PF05791.11 EKE39934.1 - 0.27 11.0 7.6 2.7 7.8 7.6 1.9 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF3185 PF11381.8 EKE39935.1 - 0.032 14.2 1.3 1.3 9.1 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) Ig_4 PF16680.5 EKE39935.1 - 1.6 9.0 6.5 0.19 12.0 0.4 2.7 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain XRN_M PF17846.1 EKE39936.1 - 1.6e-15 57.0 0.0 1.7e-15 56.9 0.0 1.0 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EKE39937.1 - 6.6e-94 313.9 0.0 6.6e-94 313.9 0.0 1.9 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EKE39937.1 - 1.4e-34 119.9 2.4 2.4e-34 119.1 2.4 1.3 1 0 0 1 1 1 1 Xrn1 helical domain BBS2_Mid PF14783.6 EKE39938.1 - 0.034 14.2 0.0 0.1 12.6 0.0 1.9 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region SGL PF08450.12 EKE39938.1 - 0.037 13.6 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region STAT_alpha PF01017.20 EKE39938.1 - 0.052 13.4 5.4 0.087 12.7 5.4 1.3 1 0 0 1 1 1 0 STAT protein, all-alpha domain EVC2_like PF12297.8 EKE39938.1 - 0.06 12.0 3.0 0.086 11.5 3.0 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein DASH_Duo1 PF08651.10 EKE39938.1 - 9.1 6.1 9.9 0.73 9.6 1.4 3.1 3 0 0 3 3 3 0 DASH complex subunit Duo1 MBR1 PF17058.5 EKE39939.1 - 0.0019 18.6 6.8 0.0024 18.2 6.8 1.2 1 0 0 1 1 1 1 Mitochondrial biogenesis regulation protein 1 DUF4783 PF16022.5 EKE39939.1 - 0.16 12.1 0.9 0.25 11.5 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4783) Ras PF00071.22 EKE39941.1 - 3.5e-61 205.5 0.6 4.1e-61 205.3 0.6 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39941.1 - 1.8e-35 121.8 0.1 3e-35 121.0 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39941.1 - 7.5e-15 54.8 0.1 9.5e-15 54.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE39941.1 - 9.5e-06 25.6 0.0 0.1 12.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE39941.1 - 4.4e-05 23.5 0.0 7.1e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE39941.1 - 0.00023 20.6 0.1 0.00037 19.9 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE39941.1 - 0.00064 19.3 0.2 0.0019 17.8 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DLIC PF05783.11 EKE39941.1 - 0.00073 18.5 0.1 0.0029 16.5 0.1 1.7 1 1 1 2 2 2 1 Dynein light intermediate chain (DLIC) ABC_tran PF00005.27 EKE39941.1 - 0.0045 17.5 0.0 0.028 14.9 0.0 1.9 1 1 1 2 2 2 1 ABC transporter AAA_24 PF13479.6 EKE39941.1 - 0.0085 15.8 0.0 0.026 14.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EKE39941.1 - 0.01 15.3 0.0 0.018 14.5 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EKE39941.1 - 0.019 14.5 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 EKE39941.1 - 0.071 13.5 0.0 0.099 13.0 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EKE39941.1 - 0.077 13.3 0.0 0.18 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EKE39941.1 - 0.087 12.3 0.0 4.6 6.7 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B Ank_2 PF12796.7 EKE39943.1 - 2.7e-21 76.0 14.5 1.9e-08 34.8 0.9 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EKE39943.1 - 4.3e-15 55.6 8.4 8.5e-07 29.1 0.5 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE39943.1 - 2.1e-13 49.1 12.2 0.0012 19.2 0.3 5.6 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 EKE39943.1 - 7.9e-12 45.5 9.4 6.4e-05 23.4 0.1 4.2 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EKE39943.1 - 2.9e-11 43.3 8.8 0.0085 16.5 0.1 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ribosomal_S17e PF00833.18 EKE39944.1 - 5.8e-37 126.3 3.5 7.2e-37 126.0 3.5 1.1 1 0 0 1 1 1 1 Ribosomal S17 Pkinase PF00069.25 EKE39945.1 - 4.5e-52 177.0 0.0 7.9e-52 176.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39945.1 - 1.4e-50 172.1 0.0 2.2e-50 171.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE39945.1 - 3.5e-06 26.0 1.3 5.9e-06 25.3 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase EphA2_TM PF14575.6 EKE39945.1 - 0.015 16.2 0.0 0.047 14.6 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain stn_TNFRSF12A PF12191.8 EKE39945.1 - 0.056 13.7 0.1 0.21 11.8 0.1 2.0 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF4010 PF13194.6 EKE39945.1 - 0.063 13.0 0.0 0.089 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) DUF5385 PF17359.2 EKE39945.1 - 0.08 12.5 1.7 0.15 11.6 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5385) DUF4381 PF14316.6 EKE39945.1 - 0.084 13.1 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Motile_Sperm PF00635.26 EKE39945.1 - 0.094 12.6 0.4 0.24 11.3 0.4 1.6 1 0 0 1 1 1 0 MSP (Major sperm protein) domain Kdo PF06293.14 EKE39945.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VSP PF03302.13 EKE39945.1 - 1.2 7.9 175.9 0.055 12.3 28.2 7.9 1 1 4 7 7 6 0 Giardia variant-specific surface protein SKG6 PF08693.10 EKE39945.1 - 5.3 6.5 9.9 9.7 5.7 9.9 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DZR PF12773.7 EKE39947.1 - 4.1e-05 23.5 3.4 0.00036 20.5 0.5 2.3 2 0 0 2 2 2 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 EKE39947.1 - 4.1e-05 23.1 8.0 0.0003 20.4 3.3 2.7 2 0 0 2 2 2 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 EKE39947.1 - 6.4e-05 22.2 1.9 6.4e-05 22.2 1.9 2.3 2 0 0 2 2 2 1 zinc-ribbon domain LIM PF00412.22 EKE39947.1 - 0.013 15.7 1.1 0.013 15.7 1.1 2.2 2 1 0 2 2 2 0 LIM domain zf-NADH-PPase PF09297.11 EKE39947.1 - 0.019 14.6 0.3 0.059 13.0 0.1 2.1 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_15 PF17032.5 EKE39947.1 - 0.02 15.7 11.2 0.12 13.1 11.2 2.2 1 1 0 1 1 1 0 zinc-ribbon family LuxS PF02664.15 EKE39947.1 - 0.043 13.5 0.4 0.074 12.7 0.4 1.4 1 0 0 1 1 1 0 S-Ribosylhomocysteinase (LuxS) DUF2333 PF10095.9 EKE39947.1 - 0.14 11.2 0.3 0.16 10.9 0.3 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) zf-RING_2 PF13639.6 EKE39947.1 - 0.44 10.9 5.2 0.78 10.1 0.1 2.4 2 1 0 2 2 2 0 Ring finger domain YdjO PF14169.6 EKE39947.1 - 7.9 6.3 9.5 29 4.5 0.2 3.1 2 1 0 2 2 2 0 Cold-inducible protein YdjO CDC45 PF02724.14 EKE39948.1 - 0.064 11.6 14.5 0.066 11.5 14.5 1.1 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 EKE39948.1 - 8.6 5.1 16.4 17 4.1 16.4 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Ras PF00071.22 EKE39949.1 - 3.4e-22 78.8 0.5 5e-22 78.2 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39949.1 - 8.2e-11 42.2 0.0 1.4e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39949.1 - 6.9e-10 38.7 0.8 1.1e-09 38.0 0.8 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE39949.1 - 4e-05 23.1 0.9 5.7e-05 22.6 0.5 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE39949.1 - 0.003 17.1 0.2 0.012 15.1 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE39949.1 - 0.004 17.2 0.0 0.0072 16.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF5409 PF17421.2 EKE39949.1 - 0.013 16.2 4.2 0.016 15.9 0.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5409) TniB PF05621.11 EKE39949.1 - 0.049 13.0 0.0 0.082 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein SPRY PF00622.28 EKE39950.1 - 3.3e-08 33.7 0.7 8.6e-08 32.3 0.7 1.7 1 0 0 1 1 1 1 SPRY domain GidB PF02527.15 EKE39950.1 - 0.05 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Inhibitor_I42 PF09394.10 EKE39951.1 - 7.4e-19 68.0 0.0 9.6e-19 67.6 0.0 1.1 1 0 0 1 1 1 1 Chagasin family peptidase inhibitor I42 Ras PF00071.22 EKE39952.1 - 9.8e-48 161.8 0.3 1.2e-47 161.5 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE39952.1 - 8e-28 97.1 0.1 1.2e-27 96.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE39952.1 - 4.5e-11 42.5 0.0 6e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE39952.1 - 1.5e-05 24.5 0.2 1.8e-05 24.2 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EKE39952.1 - 4.3e-05 23.0 0.5 6.1e-05 22.5 0.0 1.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE39952.1 - 5.1e-05 22.9 0.0 8.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain NOG1 PF06858.14 EKE39952.1 - 0.00031 20.5 0.1 0.00062 19.5 0.1 1.5 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) G-alpha PF00503.20 EKE39952.1 - 0.0022 17.2 4.5 0.0033 16.6 4.1 1.4 1 1 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EKE39952.1 - 0.0026 17.9 0.0 0.005 16.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EKE39952.1 - 0.022 14.8 0.2 0.035 14.1 0.2 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain TMEM154 PF15102.6 EKE39953.1 - 0.028 14.3 0.8 0.089 12.7 0.0 2.0 2 0 0 2 2 2 0 TMEM154 protein family Orf78 PF06024.12 EKE39953.1 - 0.029 14.7 0.0 0.064 13.6 0.0 1.5 1 0 0 1 1 1 0 Orf78 (ac78) DUF2970 PF11174.8 EKE39953.1 - 0.043 13.7 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) DUF2846 PF11008.8 EKE39953.1 - 0.33 11.0 3.9 20 5.3 0.3 4.5 6 1 0 6 6 6 0 Protein of unknown function (DUF2846) SNase PF00565.17 EKE39954.1 - 7.3e-26 90.8 26.9 1.5e-08 35.1 0.8 5.7 6 0 0 6 6 6 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EKE39954.1 - 9.2e-06 25.7 0.5 8.9e-05 22.5 0.0 2.6 1 1 1 2 2 2 1 Tudor domain EstA_Ig_like PF18435.1 EKE39954.1 - 0.016 15.4 2.7 0.052 13.7 0.6 2.8 2 0 0 2 2 2 0 Esterase Ig-like N-terminal domain START PF01852.19 EKE39955.1 - 6.5e-25 87.8 0.0 8.4e-25 87.4 0.0 1.1 1 0 0 1 1 1 1 START domain DUF2838 PF10998.8 EKE39956.1 - 1.1e-34 119.0 12.0 1.1e-34 119.0 12.0 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF2838) Pkinase PF00069.25 EKE39957.1 - 4.5e-44 150.8 13.1 2.9e-37 128.5 0.4 3.6 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE39957.1 - 2.2e-25 89.4 8.3 1e-19 70.9 0.0 4.0 4 0 0 4 4 4 2 Protein tyrosine kinase VPS28 PF03997.12 EKE39958.1 - 3.9e-07 29.9 2.7 4.6e-07 29.7 2.7 1.1 1 0 0 1 1 1 1 VPS28 protein Pox_C7_F8A PF03287.14 EKE39958.1 - 0.054 13.5 3.5 0.11 12.4 0.4 2.2 1 1 0 2 2 2 0 Poxvirus C7/F8A protein PH PF00169.29 EKE39959.1 - 0.0031 18.0 0.9 0.0031 18.0 0.9 2.0 1 1 1 2 2 2 1 PH domain Nop PF01798.18 EKE39959.1 - 0.077 12.5 1.2 1.4 8.3 0.5 2.2 2 0 0 2 2 2 0 snoRNA binding domain, fibrillarin Herpes_BLLF1 PF05109.13 EKE39961.1 - 0.086 10.8 1.8 0.11 10.5 1.8 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) PRC2_HTH_1 PF18118.1 EKE39961.1 - 0.77 10.6 8.1 0.17 12.7 3.6 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain XRN_N PF03159.18 EKE39962.1 - 7e-71 238.5 7.7 3.9e-36 124.7 0.2 2.9 2 1 1 3 3 3 2 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EKE39962.1 - 1.3e-65 222.1 5.8 4e-49 167.8 1.2 2.9 2 1 1 3 3 3 2 Xrn1 helical domain RHD3 PF05879.12 EKE39963.1 - 6.4e-140 467.7 19.8 8.3e-140 467.3 19.8 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 EKE39963.1 - 4.6e-06 26.7 0.0 1.8e-05 24.8 0.0 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EKE39963.1 - 0.0022 18.0 1.2 0.043 13.9 0.0 3.2 2 1 0 2 2 2 1 Dynamin family AAA_22 PF13401.6 EKE39963.1 - 0.17 12.1 0.1 4 7.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain NOG1_N PF17835.1 EKE39964.1 - 3.5e-50 170.1 0.1 1.2e-49 168.3 0.1 2.0 1 0 0 1 1 1 1 NOG1 N-terminal helical domain NOG1 PF06858.14 EKE39964.1 - 8.1e-26 89.6 0.0 3.1e-25 87.7 0.1 2.1 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EKE39964.1 - 1e-18 67.5 0.0 3.4e-18 65.8 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase NOGCT PF08155.11 EKE39964.1 - 3.7e-15 55.6 4.0 8.2e-15 54.5 4.0 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain FeoB_N PF02421.18 EKE39964.1 - 2.9e-10 39.9 0.1 8.8e-10 38.3 0.1 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EKE39964.1 - 0.00013 21.9 0.2 0.23 11.3 0.0 3.0 2 1 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 EKE39964.1 - 0.006 15.9 0.7 0.017 14.5 0.0 2.1 2 0 0 2 2 2 1 AIG1 family ATP_bind_1 PF03029.17 EKE39964.1 - 0.039 13.7 0.9 0.12 12.1 0.0 2.2 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Roc PF08477.13 EKE39964.1 - 0.075 13.3 0.0 6 7.1 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EKE39964.1 - 0.088 13.2 0.0 0.7 10.2 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain VIT1 PF01988.19 EKE39964.1 - 9.4 6.0 8.9 33 4.3 8.8 2.0 1 1 0 1 1 1 0 VIT family TFIIF_beta PF02270.15 EKE39965.1 - 4.5e-13 49.1 2.3 7.8e-13 48.4 0.6 2.2 3 0 0 3 3 3 1 TFIIF, beta subunit HTH domain Ribosomal_L24e PF01246.20 EKE39966.1 - 8.4e-33 112.4 6.8 2e-32 111.2 6.8 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e DUF2175 PF09943.9 EKE39966.1 - 0.036 14.3 0.9 0.036 14.3 0.9 2.6 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) Arc_trans_TRASH PF08394.10 EKE39966.1 - 0.05 14.0 0.9 0.11 12.9 0.9 1.6 1 0 0 1 1 1 0 Archaeal TRASH domain UPF1_Zn_bind PF09416.10 EKE39966.1 - 0.069 13.1 0.5 0.13 12.2 0.3 1.7 1 1 0 1 1 1 0 RNA helicase (UPF2 interacting domain) NosL PF05573.12 EKE39966.1 - 0.092 13.1 0.2 0.14 12.5 0.2 1.4 1 0 0 1 1 1 0 NosL MFS_1 PF07690.16 EKE39968.1 - 3.1e-27 95.4 66.9 8.5e-26 90.7 39.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EKE39968.1 - 4.9e-10 38.9 24.2 1.2e-07 31.0 21.0 2.9 1 1 1 2 2 2 2 Sugar (and other) transporter CLN3 PF02487.17 EKE39968.1 - 0.00035 19.7 6.7 0.018 14.1 0.5 2.5 2 0 0 2 2 2 2 CLN3 protein DUF3341 PF11821.8 EKE39968.1 - 0.011 15.4 0.3 0.039 13.6 0.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) FAM176 PF14851.6 EKE39968.1 - 0.046 13.4 0.0 0.096 12.3 0.0 1.5 1 0 0 1 1 1 0 FAM176 family GLF PF03275.13 EKE39968.1 - 0.1 12.3 1.4 0.17 11.6 1.4 1.2 1 0 0 1 1 1 0 UDP-galactopyranose mutase DUF2523 PF10734.9 EKE39968.1 - 3.5 8.3 10.8 1.3 9.6 1.2 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2523) Acetyltransf_1 PF00583.25 EKE39969.1 - 2.2e-12 47.2 0.0 2.3e-12 47.2 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EKE39969.1 - 1e-06 28.6 0.1 1.3e-06 28.3 0.1 1.1 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EKE39969.1 - 3e-06 27.6 0.0 3.4e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EKE39969.1 - 0.0001 22.3 0.0 0.00012 22.0 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EKE39969.1 - 0.0012 18.7 0.1 0.0014 18.6 0.1 1.3 1 1 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_9 PF13527.7 EKE39969.1 - 0.0045 17.0 0.0 0.0048 17.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EKE39969.1 - 0.063 13.0 0.0 0.063 13.0 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PX PF00787.24 EKE39970.1 - 1.7e-10 40.9 0.8 1.7e-10 40.9 0.8 2.0 2 0 0 2 2 2 1 PX domain SpoOE-like PF09388.10 EKE39970.1 - 0.033 14.1 0.0 0.093 12.6 0.0 1.8 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein DUF5622 PF18533.1 EKE39970.1 - 0.073 13.2 2.3 1.2 9.4 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF5622) Methyltransf_19 PF04672.12 EKE39970.1 - 0.083 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl methyltransferase F-box-like_2 PF13013.6 EKE39970.1 - 0.17 11.9 0.5 1.6 8.8 0.1 2.3 2 0 0 2 2 2 0 F-box-like domain DUF2791 PF10923.8 EKE39971.1 - 0.035 12.9 0.8 0.048 12.5 0.6 1.4 1 1 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) PBECR5 PF18814.1 EKE39971.1 - 0.069 13.1 8.0 0.089 12.7 8.0 1.2 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 Syntaxin-6_N PF09177.11 EKE39971.1 - 0.079 13.5 6.8 0.27 11.8 0.1 2.6 1 1 2 3 3 3 0 Syntaxin 6, N-terminal TetR_C_37 PF18665.1 EKE39971.1 - 0.09 13.4 0.5 0.09 13.4 0.5 2.7 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain P4Ha_N PF08336.11 EKE39971.1 - 0.14 12.1 11.2 0.054 13.5 3.2 2.2 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF4864 PF16156.5 EKE39971.1 - 0.15 12.8 4.0 0.22 12.2 1.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4864) PhaP_Bmeg PF09602.10 EKE39971.1 - 0.16 11.8 14.6 0.073 13.0 7.0 2.2 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) CobN-Mg_chel PF02514.16 EKE39971.1 - 0.18 9.5 4.9 0.2 9.4 4.9 1.0 1 0 0 1 1 1 0 CobN/Magnesium Chelatase EF-G-binding_N PF07299.11 EKE39971.1 - 0.19 12.3 14.9 0.092 13.3 4.3 3.5 1 1 3 4 4 4 0 Elongation factor G-binding protein, N-terminal FTO_CTD PF12934.7 EKE39971.1 - 0.34 10.6 5.2 0.3 10.8 0.7 2.7 2 1 1 3 3 3 0 FTO C-terminal domain Jnk-SapK_ap_N PF09744.9 EKE39971.1 - 1 9.6 11.5 26 5.0 11.3 2.2 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 TMPIT PF07851.13 EKE39971.1 - 1.4 8.1 9.6 0.2 10.9 2.7 2.0 2 0 0 2 2 2 0 TMPIT-like protein Sec34 PF04136.15 EKE39971.1 - 1.5 8.7 17.5 0.22 11.4 4.4 3.2 2 1 1 3 3 3 0 Sec34-like family Exonuc_VII_L PF02601.15 EKE39971.1 - 1.6 8.2 8.5 2.2 7.8 8.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FidL_like PF15941.5 EKE39971.1 - 1.7 9.1 6.7 0.25 11.8 1.8 2.2 2 0 0 2 2 2 0 FidL-like putative membrane protein GrpE PF01025.19 EKE39971.1 - 2 8.1 19.1 0.21 11.3 9.5 2.9 2 2 0 2 2 2 0 GrpE BLOC1_2 PF10046.9 EKE39971.1 - 6.5 7.1 16.1 0.84 10.0 2.8 3.4 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Nsp1_C PF05064.13 EKE39971.1 - 8.3 6.3 14.5 0.21 11.4 5.8 2.6 2 2 2 4 4 4 0 Nsp1-like C-terminal region APG6_N PF17675.1 EKE39971.1 - 9.2 6.8 16.9 5.2 7.6 4.2 2.5 2 1 0 2 2 2 0 Apg6 coiled-coil region LSM PF01423.22 EKE39972.1 - 7.5e-17 60.8 0.3 9.3e-17 60.5 0.3 1.1 1 0 0 1 1 1 1 LSM domain DUF1953 PF09196.10 EKE39972.1 - 0.073 12.9 0.4 0.34 10.7 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1953) ATP_bind_1 PF03029.17 EKE39973.1 - 1.4e-57 195.2 0.0 1.7e-57 195.0 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 EKE39973.1 - 0.0012 17.9 0.0 0.0018 17.3 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EKE39973.1 - 0.01 15.5 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EKE39973.1 - 0.013 15.3 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EKE39973.1 - 0.014 15.7 0.1 0.034 14.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EKE39973.1 - 0.014 15.2 0.0 0.034 13.9 0.0 1.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NTPase_1 PF03266.15 EKE39973.1 - 0.028 14.3 0.1 0.052 13.5 0.1 1.3 1 0 0 1 1 1 0 NTPase AAA_29 PF13555.6 EKE39973.1 - 0.042 13.6 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 EKE39973.1 - 0.05 13.2 0.3 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_10 PF12846.7 EKE39973.1 - 0.052 12.5 0.0 0.083 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_30 PF13604.6 EKE39973.1 - 0.06 13.1 0.0 0.093 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain KAR9 PF08580.10 EKE39973.1 - 0.096 11.2 0.1 0.12 10.9 0.1 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 AAA_33 PF13671.6 EKE39973.1 - 0.11 12.6 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EKE39973.1 - 0.12 12.6 0.3 0.2 11.9 0.3 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EKE39973.1 - 0.16 12.2 0.0 0.54 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EKE39973.1 - 0.17 12.4 0.5 0.41 11.2 0.5 1.6 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 EKE39973.1 - 0.17 11.3 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NACHT PF05729.12 EKE39973.1 - 0.19 11.6 0.3 0.51 10.2 0.3 1.6 1 0 0 1 1 1 0 NACHT domain RhoGAP PF00620.27 EKE39974.1 - 9.1e-06 25.6 0.4 2.1e-05 24.4 0.4 1.6 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 EKE39974.1 - 0.0013 18.3 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SHS2_Rpb7-N PF03876.17 EKE39974.1 - 0.092 13.1 0.0 0.29 11.5 0.0 1.8 1 0 0 1 1 1 0 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 PhoLip_ATPase_C PF16212.5 EKE39975.1 - 5.1e-59 200.0 21.9 5.1e-59 200.0 21.9 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EKE39975.1 - 1.3e-21 76.0 3.0 1.3e-21 76.0 3.0 2.5 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EKE39975.1 - 3.7e-11 43.7 0.3 1.5e-06 28.7 0.1 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EKE39975.1 - 2.1e-08 33.9 0.0 2.1e-08 33.9 0.0 3.4 3 1 1 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 EKE39975.1 - 1.4e-07 31.5 0.1 8.3e-07 29.0 0.0 2.3 3 0 0 3 3 3 1 Cation transport ATPase (P-type) TLD PF07534.16 EKE39976.1 - 2.2e-07 31.2 0.1 5.8e-07 29.8 0.1 1.7 1 0 0 1 1 1 1 TLD ATG16 PF08614.11 EKE39976.1 - 0.13 12.5 13.4 0.19 11.9 13.4 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Nipped-B_C PF12830.7 EKE39977.1 - 1.7e-18 67.3 4.4 1.7e-18 67.3 4.4 3.7 3 1 0 3 3 3 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EKE39977.1 - 1.6e-06 28.3 7.8 2.4e-06 27.7 1.4 3.7 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 EKE39977.1 - 0.00051 20.1 2.2 3.5 8.1 0.1 4.6 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 EKE39977.1 - 0.0076 16.6 1.7 28 5.2 0.3 4.5 4 1 1 5 5 5 0 HEAT repeats SPO22 PF08631.10 EKE39977.1 - 0.018 14.5 4.0 0.089 12.3 4.0 2.2 1 1 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like Cnd1 PF12717.7 EKE39977.1 - 0.055 13.5 0.2 0.055 13.5 0.2 6.3 4 2 2 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Phage_holin_3_3 PF16083.5 EKE39977.1 - 0.068 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 LydA holin phage, holin superfamily III GlutR_dimer PF00745.20 EKE39977.1 - 0.1 13.1 5.5 0.08 13.4 0.9 3.1 3 0 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain TLD PF07534.16 EKE39978.1 - 0.00013 22.2 0.0 0.00026 21.2 0.0 1.5 1 0 0 1 1 1 1 TLD MetOD2 PF18548.1 EKE39978.1 - 0.36 11.0 3.7 6.5 6.9 0.2 2.4 2 0 0 2 2 2 0 Metanogen output domain 2 Syntaxin-6_N PF09177.11 EKE39978.1 - 0.66 10.6 7.3 1 10.0 1.6 2.5 1 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF3552 PF12072.8 EKE39978.1 - 2.7 7.4 9.6 5.5 6.4 9.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) Acetyltransf_13 PF13880.6 EKE39979.1 - 1.6e-17 63.2 0.0 3.3e-17 62.2 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EKE39979.1 - 5.3e-12 45.4 2.4 9.9e-12 44.5 2.4 1.5 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.25 EKE39979.1 - 0.00045 20.4 0.0 0.0013 18.9 0.0 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EKE39979.1 - 0.011 16.1 0.1 0.025 15.0 0.1 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain PHF5 PF03660.14 EKE39980.1 - 1.4e-50 169.9 10.7 1.6e-50 169.7 10.7 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EKE39980.1 - 0.11 10.3 4.3 0.12 10.2 4.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 EKE39980.1 - 0.34 11.0 10.8 3.7 7.6 1.0 2.3 1 1 1 2 2 2 0 Double zinc ribbon Prok-RING_4 PF14447.6 EKE39980.1 - 1.7 8.5 14.3 5.2 7.0 1.0 3.4 1 1 2 3 3 3 0 Prokaryotic RING finger family 4 CEBP_ZZ PF16366.5 EKE39980.1 - 2 8.7 8.3 0.34 11.2 4.0 2.0 1 1 1 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain RecR PF02132.15 EKE39980.1 - 2.2 7.9 13.8 0.41 10.2 1.4 3.1 3 0 0 3 3 3 0 RecR protein zf-C6H2 PF15801.5 EKE39980.1 - 2.3 8.6 8.1 1.6 9.1 1.8 2.6 2 1 1 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding C1_2 PF03107.16 EKE39980.1 - 2.8 8.4 16.3 0.67 10.3 3.1 2.4 1 1 1 2 2 2 0 C1 domain DUF2039 PF10217.9 EKE39980.1 - 8.7 6.8 12.6 6.1 7.3 5.6 2.5 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) RICTOR_V PF14668.6 EKE39981.1 - 6e-05 23.2 0.1 0.00027 21.1 0.1 2.3 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, domain 5 RICTOR_M PF14666.6 EKE39981.1 - 0.0013 18.5 0.4 0.0013 18.5 0.4 4.5 5 1 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.6 EKE39981.1 - 0.0025 18.2 3.9 0.015 15.7 1.5 3.5 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain TAF4 PF05236.14 EKE39981.1 - 0.12 12.1 11.5 0.12 12.1 8.3 2.3 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family Connexin PF00029.19 EKE39981.1 - 0.27 11.0 4.1 0.8 9.4 4.1 1.8 1 0 0 1 1 1 0 Connexin NPAT_C PF15712.5 EKE39981.1 - 0.37 9.4 6.2 0.77 8.3 6.2 1.4 1 0 0 1 1 1 0 NPAT C terminus RPA43_OB PF17875.1 EKE39981.1 - 0.88 10.2 5.1 2.5 8.8 5.1 1.7 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I CPSF100_C PF13299.6 EKE39981.1 - 1.1 9.5 8.8 33 4.6 6.1 2.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal U79_P34 PF03064.16 EKE39981.1 - 2 7.7 17.7 5 6.4 17.7 1.7 1 0 0 1 1 1 0 HSV U79 / HCMV P34 FAM176 PF14851.6 EKE39981.1 - 2.4 7.8 6.2 6.6 6.4 6.2 1.7 1 0 0 1 1 1 0 FAM176 family CobT PF06213.12 EKE39981.1 - 3.5 6.9 9.6 6.9 6.0 9.6 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAM_LAG1_CLN8 PF03798.16 EKE39983.1 - 1.8e-29 102.9 20.2 2.6e-29 102.4 20.2 1.2 1 0 0 1 1 1 1 TLC domain CRM1_C PF08767.11 EKE39985.1 - 2.3e-16 59.9 10.3 2.3e-16 59.9 10.3 4.1 4 1 0 4 4 4 1 CRM1 C terminal Xpo1 PF08389.12 EKE39985.1 - 6e-07 29.6 1.6 6e-07 29.6 1.6 3.9 3 2 0 3 3 3 1 Exportin 1-like protein BP28CT PF08146.12 EKE39985.1 - 0.17 11.7 1.6 0.54 10.1 0.2 2.7 2 1 0 2 2 2 0 BP28CT (NUC211) domain AAA_assoc_C PF09821.9 EKE39985.1 - 0.86 10.2 8.7 0.18 12.3 0.4 3.5 3 0 0 3 3 3 0 C-terminal AAA-associated domain INTS5_N PF14837.6 EKE39985.1 - 3.7 7.1 9.7 0.24 11.0 0.9 3.3 3 1 0 3 3 3 0 Integrator complex subunit 5 N-terminus RhoGAP PF00620.27 EKE39986.1 - 3.7e-27 95.0 1.3 1.3e-25 90.1 0.2 3.0 2 1 0 2 2 2 1 RhoGAP domain IQ PF00612.27 EKE39986.1 - 0.086 12.7 0.1 0.2 11.5 0.1 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Sld7_C PF18596.1 EKE39986.1 - 0.13 12.5 0.6 0.41 10.8 0.1 2.2 2 0 0 2 2 2 0 Sld7 C-terminal domain LOH1CR12 PF10158.9 EKE39986.1 - 0.54 10.3 3.6 0.64 10.0 0.7 2.6 3 0 0 3 3 3 0 Tumour suppressor protein UBX PF00789.20 EKE39989.1 - 0.098 12.9 0.3 3 8.1 0.0 2.9 3 0 0 3 3 3 0 UBX domain zf-MIZ PF02891.20 EKE39990.1 - 1.3e-13 50.5 9.0 1.3e-13 50.5 9.0 2.5 3 0 0 3 3 3 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EKE39990.1 - 0.0056 16.5 4.4 0.0056 16.5 4.4 2.5 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 EKE39990.1 - 0.74 9.7 9.1 2.9 7.8 9.1 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 EKE39991.1 - 3e-45 151.9 2.6 2.1e-11 43.5 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 EKE39991.1 - 2.4e-07 30.7 2.2 0.13 12.3 0.0 4.5 4 0 0 4 4 4 3 RNA binding domain RRM_7 PF16367.5 EKE39991.1 - 2.4e-05 24.4 0.8 0.0046 17.0 0.1 3.7 3 0 0 3 3 3 1 RNA recognition motif BRAP2 PF07576.12 EKE39991.1 - 0.033 14.4 0.1 16 5.8 0.1 2.7 2 0 0 2 2 2 0 BRCA1-associated protein 2 Ish1 PF10281.9 EKE39991.1 - 0.062 13.6 0.4 4.3 7.7 0.0 3.4 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein Turandot PF07240.11 EKE39991.1 - 0.082 12.9 0.6 0.63 10.0 0.2 2.8 3 0 0 3 3 3 0 Stress-inducible humoral factor Turandot PARG_cat PF05028.14 EKE39992.1 - 3.7e-48 164.5 7.0 3.7e-48 164.5 7.0 1.4 1 1 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) U3_assoc_6 PF08640.11 EKE39993.1 - 4e-10 39.6 9.0 4e-10 39.6 9.0 3.7 4 2 1 5 5 5 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 EKE39993.1 - 0.006 17.3 0.0 26 6.0 0.0 4.3 4 1 1 5 5 5 1 Tetratricopeptide repeat CLZ PF16526.5 EKE39993.1 - 0.041 14.2 1.7 0.041 14.2 1.7 3.9 3 2 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Adaptin_N PF01602.20 EKE39994.1 - 3.8e-77 260.0 21.1 4.7e-77 259.7 21.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EKE39994.1 - 4.4e-32 111.4 5.7 4.3e-31 108.2 0.1 3.2 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKE39994.1 - 3.1e-10 40.3 0.4 3.4e-05 24.1 0.0 4.1 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 EKE39994.1 - 1e-07 31.5 1.8 0.053 13.8 0.0 5.9 6 0 0 6 6 6 2 HEAT repeat VWA PF00092.28 EKE39994.1 - 0.00067 20.0 0.1 1.4 9.2 0.0 2.7 2 0 0 2 2 2 2 von Willebrand factor type A domain RTP1_C1 PF10363.9 EKE39994.1 - 0.002 18.3 5.2 0.0079 16.4 0.1 3.5 2 2 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 VWA_2 PF13519.6 EKE39994.1 - 0.007 17.0 0.0 0.4 11.4 0.0 2.6 2 0 0 2 2 2 1 von Willebrand factor type A domain HEAT_EZ PF13513.6 EKE39994.1 - 0.038 14.5 0.3 1.7 9.3 0.1 3.5 3 1 1 4 4 4 0 HEAT-like repeat Gpi1 PF05024.15 EKE39995.1 - 7.2e-39 133.8 19.6 7.2e-39 133.8 19.6 1.9 2 1 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) DNA_methylase PF00145.17 EKE39997.1 - 2e-30 106.3 1.2 2.1e-28 99.6 1.2 2.0 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase RabGAP-TBC PF00566.18 EKE39998.1 - 0.001 18.8 22.4 0.0012 18.6 7.3 3.1 2 1 1 3 3 3 2 Rab-GTPase-TBC domain IATP PF04568.12 EKE39998.1 - 0.037 14.4 0.1 0.077 13.4 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP YppF PF14178.6 EKE39998.1 - 0.085 12.7 0.0 0.23 11.3 0.0 1.8 1 0 0 1 1 1 0 YppF-like protein MRP-S25 PF13741.6 EKE39998.1 - 0.098 12.2 2.1 0.15 11.6 2.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S25 DUF2129 PF09902.9 EKE39998.1 - 1 9.5 5.1 4.8 7.3 0.1 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2129) VPS9 PF02204.18 EKE39999.1 - 5.9e-16 58.6 2.9 1.8e-15 57.0 0.5 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain RhoGAP PF00620.27 EKE40000.1 - 1.8e-18 66.9 0.6 6e-18 65.1 0.0 2.2 3 1 0 3 3 3 1 RhoGAP domain SH3_1 PF00018.28 EKE40001.1 - 3e-23 81.1 7.1 4.3e-05 23.0 0.0 6.3 6 0 0 6 6 6 5 SH3 domain SH3_2 PF07653.17 EKE40001.1 - 9.1e-19 66.9 5.9 1.4e-07 31.1 0.1 5.5 6 0 0 6 6 6 3 Variant SH3 domain SH3_9 PF14604.6 EKE40001.1 - 1.7e-16 59.8 8.7 4.4e-06 26.5 0.6 5.1 5 0 0 5 5 5 4 Variant SH3 domain SH3_3 PF08239.11 EKE40001.1 - 0.0033 17.7 4.4 0.056 13.7 0.1 3.5 3 0 0 3 3 3 1 Bacterial SH3 domain TFIID_30kDa PF03540.13 EKE40002.1 - 5.7e-14 51.8 0.1 1.2e-13 50.8 0.1 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit PASTA PF03793.19 EKE40002.1 - 0.048 13.5 0.0 0.097 12.5 0.0 1.6 1 0 0 1 1 1 0 PASTA domain DUF2569 PF10754.9 EKE40003.1 - 0.31 11.5 9.9 0.08 13.4 5.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) DUF3290 PF11694.8 EKE40003.1 - 0.34 10.9 10.0 1.5 8.8 0.5 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3290) Pkinase PF00069.25 EKE40004.1 - 7.3e-70 235.3 0.0 8.4e-70 235.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40004.1 - 1.8e-31 109.4 0.0 3e-31 108.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EKE40004.1 - 0.00033 20.4 0.2 0.22 11.1 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EKE40004.1 - 0.0004 19.8 0.1 0.00081 18.8 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EKE40004.1 - 0.0016 17.5 0.1 0.0024 16.9 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EKE40004.1 - 0.002 17.5 0.0 0.0031 16.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EKE40004.1 - 0.011 14.8 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EKE40004.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DHHC PF01529.20 EKE40005.1 - 3.2e-19 69.3 15.1 3.2e-19 69.3 15.1 2.1 1 1 1 2 2 2 1 DHHC palmitoyltransferase zf-ribbon_3 PF13248.6 EKE40005.1 - 0.084 12.3 3.2 0.16 11.4 3.2 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Peptidase_S74 PF13884.6 EKE40006.1 - 7.6e-16 58.2 0.1 1.9e-15 56.9 0.1 1.7 1 0 0 1 1 1 1 Chaperone of endosialidase PSI PF01437.25 EKE40006.1 - 2.6 8.7 15.3 5.8 7.5 15.3 1.6 1 0 0 1 1 1 0 Plexin repeat WD40_4 PF16300.5 EKE40007.1 - 1.8e-16 59.7 0.2 2.5e-16 59.3 0.2 1.2 1 0 0 1 1 1 1 Type of WD40 repeat Angiomotin_C PF12240.8 EKE40007.1 - 0.086 12.4 0.3 0.11 12.0 0.3 1.1 1 0 0 1 1 1 0 Angiomotin C terminal IFP_35_N PF07334.13 EKE40007.1 - 0.11 12.6 1.6 0.19 11.8 1.6 1.4 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Sec2p PF06428.11 EKE40007.1 - 0.23 11.5 1.2 0.33 11.0 1.2 1.2 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p WD40 PF00400.32 EKE40008.1 - 3.6e-05 24.4 0.4 12 7.0 0.0 4.9 4 0 0 4 4 4 1 WD domain, G-beta repeat WD40_like PF17005.5 EKE40008.1 - 0.00032 20.1 4.8 0.029 13.7 2.5 2.4 2 0 0 2 2 2 2 WD40-like domain RAB3GAP2_N PF14655.6 EKE40008.1 - 0.16 11.2 0.6 0.29 10.3 0.2 1.6 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Synapsin_C PF02750.14 EKE40010.1 - 1.4e-52 178.2 0.1 3e-52 177.1 0.1 1.6 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 EKE40010.1 - 1.8e-31 108.4 0.0 6.5e-31 106.6 0.0 2.0 2 0 0 2 2 2 1 Synapsin, N-terminal domain AMP-binding PF00501.28 EKE40011.1 - 1.8e-22 79.6 0.0 2.7e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme 2-Hacid_dh PF00389.30 EKE40011.1 - 0.074 12.7 0.2 0.26 11.0 0.0 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain RasGAP PF00616.19 EKE40012.1 - 5.6e-13 49.1 8.3 4.5e-10 39.6 0.6 3.2 3 1 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase PIN_8 PF18476.1 EKE40012.1 - 0.026 14.4 0.5 0.079 12.8 0.1 1.9 2 0 0 2 2 2 0 PIN like domain LRR_4 PF12799.7 EKE40013.1 - 7.1e-05 23.1 48.0 0.001 19.4 0.1 11.3 5 3 5 12 12 12 7 Leucine Rich repeats (2 copies) WD40 PF00400.32 EKE40015.1 - 8.8e-19 67.5 0.8 1.1e-06 29.2 0.6 5.9 5 0 0 5 5 5 4 WD domain, G-beta repeat Bromodomain PF00439.25 EKE40015.1 - 9.3e-15 54.5 0.4 3.5e-14 52.6 0.4 2.0 1 0 0 1 1 1 1 Bromodomain ANAPC4_WD40 PF12894.7 EKE40015.1 - 5.2e-06 26.7 0.0 0.064 13.6 0.0 4.3 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 EKE40015.1 - 0.0086 15.4 0.2 0.054 12.8 0.1 2.2 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Fungal_trans_2 PF11951.8 EKE40015.1 - 4.7 5.9 5.0 7.9 5.2 5.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain ATG22 PF11700.8 EKE40016.1 - 3.2e-06 26.1 1.3 6.3e-06 25.1 0.1 1.8 2 0 0 2 2 2 1 Vacuole effluxer Atg22 like Connexin PF00029.19 EKE40016.1 - 3e-05 23.9 1.0 3e-05 23.9 1.0 1.9 2 0 0 2 2 2 1 Connexin PRA1 PF03208.19 EKE40016.1 - 3.1e-05 23.6 6.7 4e-05 23.3 6.7 1.1 1 0 0 1 1 1 1 PRA1 family protein V_ATPase_I PF01496.19 EKE40016.1 - 0.0001 20.4 0.4 0.00014 20.0 0.4 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Folate_carrier PF01770.18 EKE40016.1 - 0.00017 20.5 0.6 0.00017 20.5 0.6 1.6 2 0 0 2 2 2 1 Reduced folate carrier TMEM51 PF15345.6 EKE40016.1 - 0.005 16.7 2.1 0.0066 16.3 2.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 51 FPN1 PF06963.12 EKE40016.1 - 0.0068 15.0 0.2 0.011 14.3 0.2 1.3 1 0 0 1 1 1 1 Ferroportin1 (FPN1) CDC45 PF02724.14 EKE40016.1 - 0.054 11.8 5.3 0.062 11.6 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 EKE40016.1 - 0.067 12.8 7.8 0.11 12.2 7.8 1.3 1 0 0 1 1 1 0 FAM176 family YwiC PF14256.6 EKE40016.1 - 0.095 13.0 0.6 0.095 13.0 0.6 1.7 2 0 0 2 2 2 0 YwiC-like protein EOS1 PF12326.8 EKE40016.1 - 0.096 12.6 0.8 0.18 11.7 0.8 1.5 1 0 0 1 1 1 0 N-glycosylation protein CobT PF06213.12 EKE40016.1 - 0.11 11.9 12.6 0.14 11.6 12.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SUR7 PF06687.12 EKE40016.1 - 0.3 10.7 10.7 4.8 6.8 10.7 2.1 1 1 0 1 1 1 0 SUR7/PalI family EIIBC-GUT_N PF03612.14 EKE40016.1 - 0.54 10.0 4.1 0.77 9.5 4.1 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CLN3 PF02487.17 EKE40016.1 - 0.63 9.0 6.0 0.12 11.4 1.3 1.9 2 0 0 2 2 2 0 CLN3 protein DUF4746 PF15928.5 EKE40016.1 - 0.7 9.3 11.3 1 8.7 11.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CPSF100_C PF13299.6 EKE40016.1 - 0.7 10.1 7.9 0.87 9.7 7.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4530 PF15039.6 EKE40016.1 - 0.77 9.9 6.6 1.8 8.7 6.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) Shisa PF13908.6 EKE40016.1 - 1.5 9.0 4.8 2.8 8.2 0.6 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Mem_trans PF03547.18 EKE40016.1 - 3.6 5.9 10.1 4.4 5.6 10.1 1.3 1 1 0 1 1 1 0 Membrane transport protein Tyr_Deacylase PF02580.16 EKE40017.1 - 2.6e-41 141.5 0.0 3.6e-41 141.0 0.0 1.2 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Motile_Sperm PF00635.26 EKE40019.1 - 0.0002 21.2 0.3 0.0005 19.9 0.3 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain RasGEF PF00617.19 EKE40020.1 - 4.5e-30 105.1 0.1 5.6e-30 104.8 0.1 1.1 1 0 0 1 1 1 1 RasGEF domain VSP PF03302.13 EKE40021.1 - 8.2e-08 31.5 26.9 0.00026 20.0 13.6 2.0 1 1 1 2 2 2 2 Giardia variant-specific surface protein C_GCAxxG_C_C PF09719.10 EKE40022.1 - 1e-07 32.2 10.3 1.5e-06 28.5 10.3 2.0 1 1 0 1 1 1 1 Putative redox-active protein (C_GCAxxG_C_C) Ribophorin_I PF04597.14 EKE40023.1 - 9.5e-13 48.1 8.4 2.6e-12 46.7 8.4 1.8 1 1 0 1 1 1 1 Ribophorin I Cys_Met_Meta_PP PF01053.20 EKE40026.1 - 1.6e-140 468.0 0.0 1.8e-140 467.9 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EKE40026.1 - 1.1e-07 31.3 0.0 1.7e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EKE40026.1 - 1.4e-07 30.8 0.2 2.6e-05 23.4 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EKE40026.1 - 0.00017 21.0 0.2 0.00087 18.7 0.1 1.9 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Met_gamma_lyase PF06838.11 EKE40026.1 - 0.002 16.7 0.1 0.0033 16.0 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Beta_elim_lyase PF01212.21 EKE40026.1 - 0.013 14.8 0.1 0.073 12.3 0.1 2.0 1 1 0 1 1 1 0 Beta-eliminating lyase SepSecS PF05889.13 EKE40026.1 - 0.054 12.2 0.0 0.084 11.5 0.0 1.3 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Redoxin PF08534.10 EKE40026.1 - 0.063 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Redoxin Aph-1 PF06105.12 EKE40027.1 - 2.7e-05 23.7 26.3 0.00027 20.4 26.3 1.9 1 1 0 1 1 1 1 Aph-1 protein DUF2244 PF10003.9 EKE40027.1 - 5.1 6.8 7.3 3.1 7.5 0.6 2.3 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) RhoGEF PF00621.20 EKE40030.1 - 8.5e-30 104.3 1.7 1.4e-29 103.6 0.4 2.2 2 0 0 2 2 2 1 RhoGEF domain Epimerase PF01370.21 EKE40031.1 - 2.2e-26 92.8 0.0 2.9e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EKE40031.1 - 9.3e-16 58.1 0.0 1.2e-15 57.8 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EKE40031.1 - 1.9e-15 56.6 0.2 3.8e-15 55.6 0.2 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EKE40031.1 - 4.9e-14 52.6 0.0 1e-13 51.6 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EKE40031.1 - 3.4e-08 33.0 0.3 3.3e-07 29.7 0.3 2.6 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EKE40031.1 - 2.4e-07 30.2 0.0 4.9e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EKE40031.1 - 0.0006 19.0 0.0 0.001 18.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EKE40031.1 - 0.0042 16.7 0.2 0.1 12.1 0.0 2.2 2 0 0 2 2 2 1 NmrA-like family Semialdhyde_dh PF01118.24 EKE40031.1 - 0.11 12.9 0.2 0.46 10.9 0.1 2.2 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain HMG_box PF00505.19 EKE40032.1 - 9.9e-07 29.1 0.1 9.9e-07 29.1 0.1 3.1 2 1 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EKE40032.1 - 1.1e-05 25.9 0.4 1.1e-05 25.9 0.4 2.6 2 1 0 2 2 2 1 HMG-box domain Apyrase PF06079.11 EKE40033.1 - 8.2e-84 281.3 5.3 1e-83 281.0 5.3 1.0 1 0 0 1 1 1 1 Apyrase Zip PF02535.22 EKE40034.1 - 7.3e-19 68.2 0.7 7.3e-19 68.2 0.7 1.5 2 0 0 2 2 2 1 ZIP Zinc transporter DUF1514 PF07438.11 EKE40035.1 - 0.0022 17.8 5.2 0.0054 16.6 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1514) SIT PF15330.6 EKE40035.1 - 0.081 13.4 0.1 26 5.3 0.0 2.6 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT DHHC PF01529.20 EKE40035.1 - 0.13 12.3 2.9 2.2 8.4 0.4 2.4 2 0 0 2 2 2 0 DHHC palmitoyltransferase Claudin_2 PF13903.6 EKE40035.1 - 0.25 11.1 2.2 2.9 7.6 0.4 2.4 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction TMEM154 PF15102.6 EKE40035.1 - 0.34 10.8 2.1 2.1 8.2 0.1 2.4 2 0 0 2 2 2 0 TMEM154 protein family Ninjurin PF04923.12 EKE40035.1 - 0.35 10.8 6.1 0.27 11.2 0.4 2.6 2 1 0 2 2 2 0 Ninjurin Sigma_reg_N PF13800.6 EKE40035.1 - 0.78 10.1 8.2 8.4 6.8 1.0 3.0 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Orf78 PF06024.12 EKE40035.1 - 1.1 9.5 8.1 3 8.2 2.2 2.5 2 0 0 2 2 2 0 Orf78 (ac78) SNF2_N PF00176.23 EKE40036.1 - 3.2e-43 147.8 0.3 1.3e-41 142.5 0.1 2.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE40036.1 - 4.2e-13 49.6 2.4 8.2e-13 48.7 0.0 2.8 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE40036.1 - 1.4e-08 34.9 0.0 1.4e-08 34.9 0.0 3.0 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EKE40036.1 - 9.8e-05 21.4 0.1 0.00022 20.2 0.1 1.6 1 1 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DEAD PF00270.29 EKE40036.1 - 0.00045 20.0 0.0 0.0021 17.9 0.0 2.1 1 1 1 2 2 2 1 DEAD/DEAH box helicase MIT PF04212.18 EKE40036.1 - 0.045 13.8 0.3 0.14 12.2 0.3 1.9 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain His_Phos_1 PF00300.22 EKE40037.1 - 1.4e-32 112.9 0.0 1.7e-32 112.7 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Pkinase_Tyr PF07714.17 EKE40038.1 - 2e-46 158.4 0.0 3.2e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40038.1 - 1.2e-37 129.7 0.0 2e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain EphA2_TM PF14575.6 EKE40038.1 - 0.043 14.7 0.0 0.69 10.8 0.0 2.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 EKE40038.1 - 0.05 13.5 0.9 0.14 12.1 0.9 1.7 1 0 0 1 1 1 0 Syndecan domain Protocadherin PF08374.11 EKE40038.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Protocadherin SKG6 PF08693.10 EKE40038.1 - 0.63 9.5 3.5 1.2 8.6 3.5 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain CLP1_P PF16575.5 EKE40039.1 - 3.5e-38 131.3 0.2 6e-38 130.5 0.1 1.4 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EKE40039.1 - 2.3e-11 43.7 0.1 5.4e-11 42.6 0.1 1.7 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 EKE40039.1 - 2.6e-06 27.8 0.2 6.3e-06 26.6 0.2 1.6 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 ATPase_2 PF01637.18 EKE40039.1 - 0.00021 21.3 0.0 0.00042 20.3 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EKE40039.1 - 0.0042 16.8 0.0 0.0088 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EKE40039.1 - 0.0056 16.1 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 KaiC CobU PF02283.16 EKE40039.1 - 0.023 14.3 0.0 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase AAA_14 PF13173.6 EKE40039.1 - 0.052 13.6 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain RecA PF00154.21 EKE40039.1 - 0.073 12.5 0.0 0.38 10.2 0.0 1.9 2 0 0 2 2 2 0 recA bacterial DNA recombination protein T2SSE PF00437.20 EKE40039.1 - 0.11 11.6 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 EKE40039.1 - 0.13 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 EKE40040.1 - 8.8e-21 74.2 26.1 1.1e-19 70.6 19.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EKE40040.1 - 0.018 13.4 6.6 0.0092 14.4 0.9 2.3 2 1 0 2 2 2 0 Transmembrane secretion effector SHR3_chaperone PF08229.11 EKE40040.1 - 0.2 10.6 4.7 0.62 9.0 0.1 2.8 2 1 1 3 3 3 0 ER membrane protein SH3 ASC PF00858.24 EKE40040.1 - 6.9 5.5 6.0 4.4 6.1 0.5 2.3 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel Orf78 PF06024.12 EKE40041.1 - 0.011 16.0 0.0 0.026 14.8 0.0 1.7 1 0 0 1 1 1 0 Orf78 (ac78) DNA_ligase_IV PF11411.8 EKE40041.1 - 0.062 13.4 0.2 0.14 12.3 0.2 1.6 1 0 0 1 1 1 0 DNA ligase IV Chordopox_A13L PF05961.11 EKE40041.1 - 0.07 13.4 0.1 0.19 12.0 0.1 1.7 1 0 0 1 1 1 0 Chordopoxvirus A13L protein FeoB_associated PF12669.7 EKE40041.1 - 0.11 12.9 1.0 0.34 11.4 1.0 1.8 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein RicinB_lectin_2 PF14200.6 EKE40042.1 - 2.7e-12 47.2 0.1 4e-08 33.9 0.0 2.8 2 1 2 4 4 4 3 Ricin-type beta-trefoil lectin domain-like Med29 PF11568.8 EKE40042.1 - 0.067 13.4 1.9 0.077 13.2 0.6 1.7 2 0 0 2 2 2 0 Mediator complex subunit 29 DUF2935 PF11155.8 EKE40043.1 - 0.065 13.6 0.3 0.17 12.2 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Sec1 PF00995.23 EKE40044.1 - 3.3e-67 228.1 32.2 3.8e-67 227.8 32.2 1.0 1 0 0 1 1 1 1 Sec1 family DUF3876 PF12992.7 EKE40044.1 - 0.023 14.8 1.4 0.76 9.9 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function, B. Theta Gene description (DUF3876) DUF3287 PF11690.8 EKE40044.1 - 0.084 12.6 0.5 0.35 10.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) FAST_1 PF06743.15 EKE40044.1 - 0.2 11.6 2.0 0.73 9.8 0.0 3.0 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 FRP PF18032.1 EKE40044.1 - 0.87 10.2 7.4 12 6.6 0.0 4.4 4 1 1 5 5 5 0 Photoprotection regulator fluorescence recovery protein Mic1 PF07035.12 EKE40045.1 - 1.7e-20 73.3 2.1 4.2e-20 72.0 2.1 1.7 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like HSP70 PF00012.20 EKE40046.1 - 1.6e-11 43.2 6.9 2.5e-11 42.5 6.9 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE40046.1 - 2.2e-08 33.3 1.0 2.7e-07 29.7 1.0 2.1 1 1 0 1 1 1 1 MreB/Mbl protein DEDD_Tnp_IS110 PF01548.17 EKE40046.1 - 0.034 14.0 0.6 12 5.7 0.0 3.6 4 0 0 4 4 4 0 Transposase Raco_middle PF17651.1 EKE40046.1 - 0.042 13.5 0.1 0.11 12.1 0.1 1.7 1 0 0 1 1 1 0 RACo middle region Proteasom_Rpn13 PF04683.13 EKE40046.1 - 0.051 14.1 2.0 0.45 11.1 0.2 2.9 3 0 0 3 3 3 0 Proteasome complex subunit Rpn13 ubiquitin receptor COMM_domain PF07258.14 EKE40046.1 - 0.085 13.0 5.4 2.1 8.5 0.6 4.3 5 0 0 5 5 5 0 COMM domain Ras PF00071.22 EKE40047.1 - 1.5e-51 174.2 0.2 1.8e-51 174.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40047.1 - 8.1e-18 64.8 0.0 1.4e-17 64.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40047.1 - 4.7e-08 32.7 0.0 5.5e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE40047.1 - 1.3e-05 25.2 0.0 2.1e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE40047.1 - 6.1e-05 22.6 0.1 0.0002 21.0 0.1 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EKE40047.1 - 0.023 14.2 0.1 1.2 8.6 0.0 2.2 2 1 0 2 2 2 0 Ferrous iron transport protein B Gtr1_RagA PF04670.12 EKE40047.1 - 0.13 11.6 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PARP PF00644.20 EKE40049.1 - 4.1e-08 33.1 0.1 4.1e-08 33.1 0.1 1.8 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain RWD PF05773.22 EKE40049.1 - 0.0013 19.0 0.1 0.0086 16.4 0.1 2.5 1 1 0 1 1 1 1 RWD domain PTS_2-RNA PF01885.16 EKE40049.1 - 0.007 16.4 0.2 0.24 11.4 0.3 2.8 2 1 0 2 2 2 1 RNA 2'-phosphotransferase, Tpt1 / KptA family PhnA_Zn_Ribbon PF08274.12 EKE40049.1 - 0.048 13.6 5.0 0.24 11.4 5.0 2.3 1 0 0 1 1 1 0 PhnA Zinc-Ribbon PP2C PF00481.21 EKE40050.1 - 1.9e-49 168.7 0.0 2.5e-49 168.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EKE40050.1 - 3.7e-39 132.3 58.2 9.8e-10 38.1 3.6 9.6 3 3 6 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 EKE40050.1 - 5.7e-36 121.9 72.1 9.2e-05 22.7 4.4 11.6 9 2 1 11 11 11 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EKE40050.1 - 3e-09 36.6 33.8 0.028 13.9 1.0 6.3 2 2 5 7 7 7 7 Leucine-rich repeat LRR_1 PF00560.33 EKE40050.1 - 0.00044 20.4 61.0 0.55 11.0 0.8 15.0 16 2 0 16 16 16 4 Leucine Rich Repeat PP2C_2 PF13672.6 EKE40050.1 - 0.0012 18.6 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Asparaginase PF00710.20 EKE40051.1 - 1.1e-60 204.5 0.0 1.6e-60 203.9 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EKE40051.1 - 1.4e-30 105.8 0.5 3e-30 104.8 0.5 1.6 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain PP2C PF00481.21 EKE40052.1 - 2.6e-59 201.0 0.0 3.5e-59 200.5 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EKE40052.1 - 5e-36 122.3 109.9 8.3e-07 28.7 10.0 11.5 5 2 8 14 14 14 12 Leucine rich repeat LRR_4 PF12799.7 EKE40052.1 - 8.2e-30 102.4 130.5 0.00089 19.6 7.2 14.4 4 4 10 17 17 17 17 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EKE40052.1 - 0.00025 20.6 57.1 0.00056 19.5 2.5 7.0 1 1 5 7 7 7 4 Leucine-rich repeat LRR_12 PF18837.1 EKE40052.1 - 0.46 10.2 3.0 0.53 10.0 0.1 2.7 2 0 0 2 2 2 0 Leucine-rich repeat NUDIX PF00293.28 EKE40053.1 - 1.5e-12 47.7 0.1 2.5e-12 46.9 0.1 1.3 1 0 0 1 1 1 1 NUDIX domain DZR PF12773.7 EKE40053.1 - 0.0018 18.3 1.3 0.0048 16.9 1.3 1.7 1 0 0 1 1 1 1 Double zinc ribbon zf-NADH-PPase PF09297.11 EKE40053.1 - 0.025 14.3 3.2 0.054 13.2 3.2 1.6 1 1 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain RecR PF02132.15 EKE40053.1 - 0.026 14.1 0.9 0.097 12.3 0.0 2.2 2 0 0 2 2 2 0 RecR protein DUF3797 PF12677.7 EKE40053.1 - 0.89 9.5 6.1 0.27 11.2 0.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) RNA_POL_M_15KD PF02150.16 EKE40053.1 - 2.1 8.3 5.5 12 5.9 0.2 2.5 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit MIG-14_Wnt-bd PF06664.12 EKE40054.1 - 5.7e-14 52.0 39.0 5.7e-14 52.0 39.0 1.7 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion ChlI PF13541.6 EKE40054.1 - 0.0033 17.3 0.1 0.0062 16.4 0.1 1.3 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase RRM_1 PF00076.22 EKE40055.1 - 4.3e-21 74.5 0.5 3.8e-09 36.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKE40055.1 - 5.7e-07 29.2 0.4 2.8e-06 26.9 0.0 2.1 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EKE40055.1 - 2.9e-05 24.0 2.3 0.087 12.9 0.1 2.6 2 1 1 3 3 3 2 RNA binding motif RRM_occluded PF16842.5 EKE40055.1 - 0.0039 17.0 0.0 0.22 11.4 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif SMC_N PF02463.19 EKE40056.1 - 5.4e-47 160.0 58.3 5.1e-27 94.7 14.6 5.1 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EKE40056.1 - 1.2e-16 61.1 0.2 4.6e-16 59.2 0.2 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EKE40056.1 - 1.2e-13 52.0 32.6 1.2e-13 52.0 32.6 8.5 2 2 2 4 4 4 1 AAA domain AAA_21 PF13304.6 EKE40056.1 - 1.9e-11 44.4 2.8 6.2e-07 29.5 0.0 4.5 4 2 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EKE40056.1 - 5.7e-09 36.1 23.8 5.7e-09 36.1 23.8 5.0 1 1 4 5 5 5 1 AAA ATPase domain AAA_29 PF13555.6 EKE40056.1 - 6.5e-06 25.8 0.0 1.3e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain T3SS_ATPase_C PF18269.1 EKE40056.1 - 0.00026 20.8 3.0 0.00026 20.8 3.0 3.1 2 0 0 2 2 2 1 T3SS EscN ATPase C-terminal domain SbcCD_C PF13558.6 EKE40056.1 - 0.03 14.6 0.0 0.1 12.8 0.0 2.0 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 EKE40056.1 - 0.12 12.9 0.0 0.12 12.9 0.0 7.3 3 2 1 4 4 4 0 ABC transporter Glyco_transf_28 PF03033.20 EKE40056.1 - 7.2 6.7 7.0 1.2 9.1 1.1 2.8 3 0 0 3 3 3 0 Glycosyltransferase family 28 N-terminal domain Fungal_TACC PF12709.7 EKE40057.1 - 0.03 14.7 4.5 0.03 14.7 4.5 2.2 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins RRM_1 PF00076.22 EKE40058.1 - 7.6e-08 32.1 0.3 2e-07 30.7 0.1 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4982 PF16355.5 EKE40058.1 - 0.088 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4982) TagA PF12561.8 EKE40058.1 - 1.1 9.7 4.0 5.8 7.4 0.2 2.6 3 0 0 3 3 3 0 ToxR activated gene A lipoprotein domain Pkinase_Tyr PF07714.17 EKE40059.1 - 9.5e-28 97.2 0.2 2e-27 96.1 0.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40059.1 - 1.3e-25 90.3 0.4 2.1e-25 89.6 0.4 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EKE40059.1 - 7.9e-15 55.0 0.0 5.5e-05 23.6 0.0 3.8 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE40059.1 - 3e-11 43.3 0.0 0.0006 20.1 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKE40059.1 - 2.2e-10 41.0 0.0 0.0014 19.1 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKE40059.1 - 4.6e-05 23.5 0.0 0.62 10.8 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EKE40059.1 - 0.01 16.3 0.2 0.88 10.1 0.0 3.6 3 0 0 3 3 3 0 Ankyrin repeat UNC45-central PF11701.8 EKE40059.1 - 0.029 14.3 0.5 5.1 7.0 0.1 2.7 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central Kinase-like PF14531.6 EKE40059.1 - 0.091 12.1 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Kinase-like MAR_sialic_bdg PF10564.9 EKE40059.1 - 0.18 11.9 0.3 0.36 10.9 0.3 1.5 1 0 0 1 1 1 0 Sialic-acid binding micronemal adhesive repeat DUF900 PF05990.12 EKE40060.1 - 7.7e-18 64.9 0.0 1.3e-17 64.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DC_STAMP PF07782.13 EKE40060.1 - 0.051 13.4 7.1 0.1 12.4 7.1 1.4 1 0 0 1 1 1 0 DC-STAMP-like protein SRTM1 PF15872.5 EKE40060.1 - 1 9.5 4.9 1.3 9.2 0.9 2.6 2 0 0 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 DUF2207 PF09972.9 EKE40060.1 - 3.6 6.2 6.7 0.5 9.1 1.7 2.0 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Pkinase_Tyr PF07714.17 EKE40061.1 - 8.2e-39 133.4 0.1 1.4e-38 132.6 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40061.1 - 8.3e-39 133.5 0.3 1.5e-38 132.7 0.3 1.4 1 0 0 1 1 1 1 Protein kinase domain VSP PF03302.13 EKE40061.1 - 0.0049 15.8 240.6 0.055 12.3 42.4 9.2 2 1 7 9 9 9 6 Giardia variant-specific surface protein Kdo PF06293.14 EKE40061.1 - 0.0054 16.1 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKE40061.1 - 0.069 11.9 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase BatA PF07584.11 EKE40061.1 - 0.13 12.7 0.3 0.24 11.8 0.3 1.3 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal Pox_EPC_I2-L1 PF12575.8 EKE40063.1 - 0.035 14.3 0.4 0.064 13.5 0.4 1.4 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 KleE PF17394.2 EKE40063.1 - 0.044 14.0 0.0 0.056 13.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized KleE stable inheritance protein Orf78 PF06024.12 EKE40063.1 - 0.047 14.0 0.3 0.058 13.7 0.3 1.4 1 1 0 1 1 1 0 Orf78 (ac78) V_ATPase_I PF01496.19 EKE40067.1 - 1.1e-53 182.4 10.0 1.2e-53 182.2 10.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family THDPS_N PF14790.6 EKE40067.1 - 0.0089 15.9 0.1 0.012 15.4 0.1 1.1 1 0 0 1 1 1 1 Tetrahydrodipicolinate N-succinyltransferase N-terminal LRR_8 PF13855.6 EKE40068.1 - 5e-59 195.9 108.1 2.9e-09 36.5 5.5 11.0 3 2 12 15 15 15 13 Leucine rich repeat PP2C PF00481.21 EKE40068.1 - 9.5e-55 186.0 0.1 1.3e-54 185.6 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 EKE40068.1 - 8.2e-42 140.5 81.9 8.4e-06 26.1 1.3 13.5 6 4 7 15 15 15 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EKE40068.1 - 3.5e-07 29.9 40.9 0.0016 18.0 3.0 6.3 1 1 3 6 6 6 6 Leucine-rich repeat LRR_1 PF00560.33 EKE40068.1 - 7.1e-06 25.9 47.8 1.5 9.6 0.5 14.3 13 2 0 13 13 13 3 Leucine Rich Repeat PP2C_2 PF13672.6 EKE40068.1 - 3.4e-05 23.6 0.0 6.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Phage_int_SAM_5 PF13102.6 EKE40068.1 - 0.12 12.7 0.2 13 6.2 0.0 2.8 2 0 0 2 2 2 0 Phage integrase SAM-like domain Importin_rep_2 PF18786.1 EKE40068.1 - 0.18 11.7 1.9 0.47 10.3 0.2 2.8 2 1 0 2 2 2 0 Importin 13 repeat LRR_6 PF13516.6 EKE40068.1 - 4.8 7.5 67.4 0.81 9.9 0.4 14.3 16 0 0 16 16 16 0 Leucine Rich repeat CH PF00307.31 EKE40069.1 - 3.6e-52 175.1 0.2 3.3e-26 91.6 0.0 2.8 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EKE40069.1 - 2.2e-10 40.2 0.0 1.7e-06 27.8 0.0 2.6 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.6 EKE40069.1 - 2.1e-05 24.1 0.8 0.0001 21.9 0.4 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EKE40069.1 - 8.5e-05 21.8 0.3 0.00033 20.0 0.3 2.1 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 EKE40069.1 - 0.00011 21.5 0.3 0.00035 19.9 0.3 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EKE40069.1 - 0.00025 21.4 0.6 0.002 18.5 0.6 2.6 1 1 1 2 2 2 1 EF-hand domain pair EFhand_Ca_insen PF08726.10 EKE40069.1 - 0.00025 21.1 0.1 0.0016 18.5 0.0 2.5 2 0 0 2 2 2 1 Ca2+ insensitive EF hand Spectrin PF00435.21 EKE40069.1 - 0.004 17.6 5.9 0.03 14.8 0.7 3.2 2 1 1 3 3 3 1 Spectrin repeat DUF3450 PF11932.8 EKE40069.1 - 0.017 14.4 1.7 8 5.7 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) EF-hand_8 PF13833.6 EKE40069.1 - 0.27 11.1 2.0 5.1 7.0 0.2 3.2 2 1 1 3 3 3 0 EF-hand domain pair Muted PF14942.6 EKE40069.1 - 0.28 11.5 8.3 0.45 10.8 0.3 3.1 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein DUF3298 PF11738.8 EKE40069.1 - 3.8 8.6 6.8 0.61 11.2 0.4 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3298) DUF5082 PF16888.5 EKE40069.1 - 8.9 6.6 9.0 88 3.4 0.1 3.9 2 2 0 2 2 2 0 Domain of unknown function (DUF5082) CitMHS PF03600.16 EKE40070.1 - 2.8e-24 85.8 52.8 3.3e-23 82.3 26.1 2.3 1 1 1 2 2 2 2 Citrate transporter Metallophos PF00149.28 EKE40071.1 - 1.9e-33 116.7 0.5 2.6e-33 116.3 0.5 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EKE40071.1 - 0.00013 22.4 3.1 0.00024 21.5 3.1 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 EKE40071.1 - 0.076 13.2 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Ras PF00071.22 EKE40072.1 - 1.4e-47 161.3 1.3 1.6e-47 161.1 1.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40072.1 - 1.3e-16 60.9 0.0 2.6e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40072.1 - 1.6e-08 34.2 0.2 2.1e-08 33.8 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE40072.1 - 0.00021 20.9 0.0 0.0004 20.0 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE40072.1 - 0.0015 18.5 1.4 0.027 14.4 0.2 2.3 2 1 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 EKE40072.1 - 0.012 15.3 1.2 0.064 13.0 0.1 2.0 1 1 1 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EKE40072.1 - 0.023 14.8 0.3 0.054 13.6 0.3 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF1922 PF09082.10 EKE40072.1 - 0.053 13.8 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1922) DHHC PF01529.20 EKE40073.1 - 1.3e-24 86.8 20.3 1.3e-24 86.8 20.3 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase ABC_tran PF00005.27 EKE40074.1 - 3.3e-45 154.0 2.0 2.9e-24 86.1 0.0 3.2 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EKE40074.1 - 3.9e-15 56.5 7.5 0.0011 18.8 0.1 4.4 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EKE40074.1 - 1.2e-07 31.4 10.2 0.006 16.0 0.0 4.6 4 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EKE40074.1 - 2.5e-05 24.6 1.8 0.0097 16.2 0.0 3.7 3 1 1 4 4 4 1 AAA domain RsgA_GTPase PF03193.16 EKE40074.1 - 0.00012 22.0 0.1 0.028 14.3 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EKE40074.1 - 0.00015 21.4 1.7 0.13 12.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EKE40074.1 - 0.00028 21.0 0.3 0.24 11.5 0.0 3.1 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA PF00004.29 EKE40074.1 - 0.00069 20.0 0.0 0.066 13.6 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EKE40074.1 - 0.0009 19.8 0.5 0.051 14.1 0.0 3.3 3 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EKE40074.1 - 0.0011 19.3 0.0 0.062 13.7 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EKE40074.1 - 0.0012 18.8 0.0 2 8.3 0.0 2.7 2 0 0 2 2 2 2 NACHT domain AAA_25 PF13481.6 EKE40074.1 - 0.0021 17.6 0.0 0.49 10.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EKE40074.1 - 0.0029 17.8 0.4 0.25 11.6 0.1 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.22 EKE40074.1 - 0.0042 17.5 0.3 0.45 10.9 0.0 2.6 2 0 0 2 2 2 1 RNA helicase NB-ARC PF00931.22 EKE40074.1 - 0.005 16.0 0.9 0.6 9.3 0.0 2.7 2 0 0 2 2 2 1 NB-ARC domain AAA_30 PF13604.6 EKE40074.1 - 0.017 14.8 0.1 0.11 12.3 0.0 2.3 3 1 0 3 3 3 0 AAA domain DUF815 PF05673.13 EKE40074.1 - 0.025 13.7 0.0 0.44 9.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_15 PF13175.6 EKE40074.1 - 0.026 14.2 0.2 0.026 14.2 0.2 5.2 2 2 1 3 3 3 0 AAA ATPase domain IstB_IS21 PF01695.17 EKE40074.1 - 0.058 13.1 0.5 18 5.0 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein CPSase_L_D3 PF02787.19 EKE40074.1 - 0.076 13.4 3.1 2.4 8.5 1.6 2.6 2 0 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain AAA_7 PF12775.7 EKE40074.1 - 0.081 12.4 0.8 1.6 8.2 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 EKE40074.1 - 0.15 11.8 0.0 0.15 11.8 0.0 3.8 4 0 0 4 4 4 0 AAA domain AAA_5 PF07728.14 EKE40074.1 - 0.18 11.8 0.4 2.2 8.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 EKE40074.1 - 5.6 7.0 7.4 5.5 7.0 0.0 3.3 3 0 0 3 3 3 0 Helicase HerA, central domain PUF PF00806.19 EKE40075.1 - 8.4e-32 107.1 19.3 4.5e-06 26.0 0.5 8.5 8 0 0 8 8 8 7 Pumilio-family RNA binding repeat DUF5071 PF16804.5 EKE40075.1 - 0.016 15.5 0.4 4.4 7.6 0.1 3.1 2 1 0 3 3 3 0 Domain of unknown function (DUF5071) Dpoe2NT PF12213.8 EKE40075.1 - 0.036 14.3 0.3 0.73 10.2 0.0 3.1 2 1 1 3 3 3 0 DNA polymerases epsilon N terminal DUF87 PF01935.17 EKE40075.1 - 8.1 6.5 8.3 0.43 10.6 0.3 2.3 2 1 0 2 2 2 0 Helicase HerA, central domain Macro PF01661.21 EKE40076.1 - 3.3e-25 88.4 0.6 6.6e-25 87.5 0.0 1.8 2 0 0 2 2 2 1 Macro domain ZapB PF06005.12 EKE40077.1 - 4.7e-05 23.8 2.3 9.6e-05 22.8 2.3 1.5 1 0 0 1 1 1 1 Cell division protein ZapB JIP_LZII PF16471.5 EKE40077.1 - 0.0019 18.3 1.2 0.0019 18.3 1.2 1.7 2 0 0 2 2 2 1 JNK-interacting protein leucine zipper II TLD PF07534.16 EKE40077.1 - 0.0033 17.7 4.5 0.0058 16.9 4.5 1.4 1 0 0 1 1 1 1 TLD Cnn_1N PF07989.11 EKE40077.1 - 0.019 15.1 6.5 0.038 14.1 6.5 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 Rhamno_transf PF11316.8 EKE40077.1 - 0.073 12.4 0.1 0.33 10.3 0.1 1.8 1 1 1 2 2 2 0 Putative rhamnosyl transferase FANCAA PF15146.6 EKE40077.1 - 0.098 11.7 1.8 0.14 11.2 1.8 1.1 1 0 0 1 1 1 0 Fanconi anemia-associated YabA PF06156.13 EKE40077.1 - 0.099 13.3 4.7 0.16 12.6 4.7 1.4 1 0 0 1 1 1 0 Initiation control protein YabA DUF2205 PF10224.9 EKE40077.1 - 0.11 12.5 5.9 0.24 11.4 5.9 1.5 1 0 0 1 1 1 0 Short coiled-coil protein DivIC PF04977.15 EKE40077.1 - 0.19 11.5 4.2 0.51 10.2 4.2 1.7 1 0 0 1 1 1 0 Septum formation initiator HALZ PF02183.18 EKE40077.1 - 0.2 11.9 7.4 0.12 12.6 4.8 2.1 2 0 0 2 2 1 0 Homeobox associated leucine zipper bZIP_1 PF00170.21 EKE40077.1 - 0.2 11.8 8.6 0.13 12.3 6.1 2.0 1 1 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 EKE40077.1 - 0.22 11.7 7.0 0.49 10.5 7.0 1.6 1 0 0 1 1 1 0 Basic region leucine zipper CENP-H PF05837.12 EKE40077.1 - 0.43 11.0 4.6 0.65 10.4 4.6 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) VPS11_C PF12451.8 EKE40077.1 - 0.5 10.6 4.7 0.15 12.3 0.8 2.3 3 0 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal NYD-SP28_assoc PF14775.6 EKE40077.1 - 2.3 8.4 6.1 11 6.2 6.1 2.1 1 1 0 1 1 1 0 Sperm tail C-terminal domain Ribosomal_L6e PF01159.19 EKE40077.1 - 2.8 8.5 8.7 10 6.7 5.1 2.2 2 0 0 2 2 2 0 Ribosomal protein L6e PikAIV_N PF18605.1 EKE40077.1 - 5.6 6.6 6.5 5.9 6.6 5.2 1.8 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain MIG-14_Wnt-bd PF06664.12 EKE40078.1 - 0.00032 20.0 2.9 0.00035 19.9 2.9 1.0 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion ESSS PF10183.9 EKE40078.1 - 0.18 12.1 1.0 0.3 11.3 0.0 1.8 1 1 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) BCCT PF02028.17 EKE40078.1 - 0.52 8.7 6.9 0.64 8.4 6.9 1.0 1 0 0 1 1 1 0 BCCT, betaine/carnitine/choline family transporter Frag1 PF10277.9 EKE40078.1 - 1.3 8.6 11.9 1.8 8.1 11.9 1.2 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family ISK_Channel PF02060.15 EKE40078.1 - 6.3 6.5 5.6 16 5.2 2.6 2.1 1 1 1 2 2 2 0 Slow voltage-gated potassium channel AMP-binding PF00501.28 EKE40079.1 - 3.7e-71 239.9 0.0 5e-71 239.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EKE40079.1 - 2.4e-39 135.0 0.1 1.8e-38 132.2 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein AMP-binding_C PF13193.6 EKE40079.1 - 2.4e-15 57.3 0.0 6.8e-15 55.8 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Epimerase PF01370.21 EKE40079.1 - 1.7e-07 30.9 0.0 3.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EKE40079.1 - 0.00053 20.3 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 EKE40079.1 - 0.0024 17.8 0.0 0.0044 17.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Glu_dehyd_C PF16912.5 EKE40079.1 - 0.015 14.7 0.0 0.066 12.7 0.0 1.9 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus 3Beta_HSD PF01073.19 EKE40079.1 - 0.022 13.8 1.6 0.028 13.5 0.2 1.9 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EKE40079.1 - 0.045 13.2 0.0 0.15 11.4 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DUF2418 PF10332.9 EKE40079.1 - 0.06 13.9 0.0 0.21 12.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) zf-C3HC4_3 PF13920.6 EKE40080.1 - 3.2e-05 23.7 13.5 0.00019 21.2 10.5 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE40080.1 - 0.0028 17.5 11.4 0.0028 17.5 11.4 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE40080.1 - 0.0094 15.8 11.0 0.0094 15.8 11.0 3.1 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 DUF771 PF05595.11 EKE40080.1 - 0.018 15.0 0.1 0.087 12.8 0.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF771) B-block_TFIIIC PF04182.12 EKE40080.1 - 2 8.6 6.5 12 6.2 1.2 3.1 2 1 0 2 2 2 0 B-block binding subunit of TFIIIC zf-rbx1 PF12678.7 EKE40080.1 - 8.2 6.8 14.1 1.6 9.1 8.9 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain FRG1 PF06229.12 EKE40081.1 - 0.058 13.1 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 FRG1-like domain RabGAP-TBC PF00566.18 EKE40082.1 - 3.9e-26 92.0 16.9 6e-26 91.4 16.0 1.9 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.25 EKE40083.1 - 1.2e-45 155.9 0.1 2.7e-45 154.8 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40083.1 - 1.9e-29 102.7 1.0 6.6e-29 101.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Ribonuc_2-5A PF06479.12 EKE40083.1 - 1.9e-28 99.1 1.2 6.4e-28 97.5 1.2 1.9 1 0 0 1 1 1 1 Ribonuclease 2-5A Kinase-like PF14531.6 EKE40083.1 - 0.00077 18.9 0.0 0.002 17.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EKE40083.1 - 0.0051 15.6 0.9 0.02 13.7 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 EKE40083.1 - 0.078 12.9 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family TMEM154 PF15102.6 EKE40083.1 - 0.2 11.6 2.7 0.43 10.5 2.7 1.4 1 0 0 1 1 1 0 TMEM154 protein family Orf78 PF06024.12 EKE40083.1 - 1.5 9.2 7.7 0.13 12.6 2.4 2.0 2 0 0 2 2 2 0 Orf78 (ac78) CortBP2 PF09727.9 EKE40083.1 - 7.6 6.4 8.5 10 6.0 0.7 2.3 2 0 0 2 2 2 0 Cortactin-binding protein-2 WW PF00397.26 EKE40084.1 - 0.0015 18.5 0.9 0.0033 17.5 0.9 1.6 1 0 0 1 1 1 1 WW domain Arrestin_N PF00339.29 EKE40084.1 - 0.0021 18.1 0.0 0.0056 16.7 0.0 1.7 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EKE40084.1 - 0.01 15.5 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Arrestin_N terminal like C2 PF00168.30 EKE40084.1 - 0.043 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 C2 domain Mannosyl_trans2 PF04188.13 EKE40085.1 - 5.4e-66 223.7 40.9 6.9e-66 223.4 40.9 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) GDPD PF03009.17 EKE40086.1 - 1.3e-28 100.5 0.0 4.8e-24 85.5 0.0 2.1 2 0 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 EKE40086.1 - 0.0061 17.0 0.0 0.014 15.9 0.0 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family SIT PF15330.6 EKE40086.1 - 0.14 12.7 0.3 0.14 12.7 0.3 1.7 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT RhoGAP PF00620.27 EKE40087.1 - 4.6e-08 33.0 0.2 1e-07 31.9 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain DUF3657 PF12394.8 EKE40087.1 - 0.05 14.2 2.7 0.57 10.8 0.1 2.6 2 0 0 2 2 2 0 Protein FAM135 POR_N PF01855.19 EKE40087.1 - 0.2 11.4 0.0 0.65 9.7 0.0 1.7 1 1 1 2 2 2 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg RhoGAP PF00620.27 EKE40088.1 - 2.4e-10 40.4 0.0 1.4e-09 37.9 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain C1_1 PF00130.22 EKE40091.1 - 4.3e-05 23.3 6.8 4.3e-05 23.3 6.8 3.3 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 EKE40091.1 - 0.0023 17.8 14.9 0.0023 17.8 14.9 2.7 2 0 0 2 2 2 1 PHD-finger zf-RING-like PF08746.11 EKE40091.1 - 4.6 7.6 19.7 1.3 9.4 15.9 2.1 2 0 0 2 2 2 0 RING-like domain RINGv PF12906.7 EKE40091.1 - 8.6 6.6 13.0 8.9 6.5 11.2 2.0 2 0 0 2 2 2 0 RING-variant domain Metallophos PF00149.28 EKE40093.1 - 5.2e-38 131.6 0.3 1.4e-37 130.2 0.2 1.7 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE40093.1 - 0.0033 17.6 0.0 0.0047 17.1 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Alpha-amylase PF00128.24 EKE40094.1 - 0.0049 16.5 0.1 0.078 12.5 0.0 2.3 1 1 1 2 2 2 1 Alpha amylase, catalytic domain UQ_con PF00179.26 EKE40095.1 - 1.1e-49 167.6 0.0 1.3e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKE40095.1 - 0.00082 19.1 0.0 0.0014 18.3 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B Adeno_E3_14_5 PF04834.12 EKE40095.1 - 0.0034 17.9 0.2 0.0049 17.4 0.2 1.2 1 0 0 1 1 1 1 Early E3 14.5 kDa protein Ribosomal_S30 PF04758.14 EKE40096.1 - 2.2e-22 79.0 8.6 2.5e-22 78.8 8.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Metallophos PF00149.28 EKE40097.1 - 0.015 15.8 0.0 0.023 15.2 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase DUF5305 PF17231.2 EKE40100.1 - 0.052 12.9 1.3 0.08 12.3 0.1 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5305) DUF3112 PF11309.8 EKE40100.1 - 0.32 10.4 4.8 1.6 8.2 2.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3112) zf-LITAF-like PF10601.9 EKE40100.1 - 0.37 11.1 1.1 0.64 10.3 0.1 1.8 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain DUF2207 PF09972.9 EKE40100.1 - 1.4 7.6 5.7 7.5 5.2 6.0 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Orf78 PF06024.12 EKE40100.1 - 2.1 8.7 4.4 2.8 8.3 0.0 2.1 1 1 1 2 2 2 0 Orf78 (ac78) Foamy_BEL PF03274.14 EKE40101.1 - 0.038 13.3 0.4 0.094 12.0 0.1 1.8 2 1 0 2 2 2 0 Foamy virus BEL 1/2 protein Pkinase PF00069.25 EKE40102.1 - 2.8e-63 213.7 0.0 4.7e-63 213.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40102.1 - 1.7e-42 145.5 0.0 2.6e-42 144.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE40102.1 - 1.7e-17 63.8 1.3 3.5e-17 62.8 1.3 1.6 1 0 0 1 1 1 1 PH domain PBD PF00786.28 EKE40102.1 - 9.9e-11 41.8 0.0 2.3e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain PH_3 PF14593.6 EKE40102.1 - 3.8e-09 36.6 0.1 1e-08 35.2 0.1 1.7 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 EKE40102.1 - 1.5e-05 23.9 0.1 2.6e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKE40102.1 - 8.9e-05 21.9 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EKE40102.1 - 0.0033 16.4 3.4 0.048 12.6 3.4 2.0 1 1 0 1 1 1 1 Haspin like kinase domain PH_11 PF15413.6 EKE40102.1 - 0.0057 17.1 7.7 0.021 15.2 4.4 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EKE40102.1 - 0.011 16.0 0.1 0.03 14.6 0.1 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain Kdo PF06293.14 EKE40102.1 - 0.093 12.1 0.2 0.15 11.4 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RhoGEF PF00621.20 EKE40103.1 - 3.8e-33 115.3 7.5 3.8e-33 115.3 7.5 2.0 2 0 0 2 2 2 1 RhoGEF domain Laminin_II PF06009.12 EKE40103.1 - 0.063 13.3 0.9 0.59 10.1 0.2 2.4 2 0 0 2 2 2 0 Laminin Domain II zf-CCHC PF00098.23 EKE40104.1 - 2.1e-21 75.0 34.1 2.3e-06 27.4 1.6 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_4 PF14392.6 EKE40104.1 - 0.036 13.8 27.2 2 8.2 2.0 4.2 4 0 0 4 4 4 0 Zinc knuckle zf-CCHC_2 PF13696.6 EKE40104.1 - 0.18 11.7 37.2 0.44 10.4 2.5 4.4 4 0 0 4 4 4 0 Zinc knuckle TRAF6_Z2 PF18048.1 EKE40104.1 - 0.61 10.2 15.4 4.5 7.5 0.4 4.3 4 0 0 4 4 4 0 TNF receptor-associated factor 6 zinc finger 2 SNF2_N PF00176.23 EKE40105.1 - 5.6e-66 222.6 2.7 1.2e-65 221.5 2.7 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE40105.1 - 1.3e-21 77.0 0.0 6.4e-21 74.8 0.0 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 EKE40105.1 - 2.2e-16 59.5 17.6 6.7e-12 45.1 3.4 3.6 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 EKE40105.1 - 4.1e-10 39.9 0.2 4.1e-10 39.9 0.2 3.8 3 2 0 3 3 3 1 Type III restriction enzyme, res subunit DUF4208 PF13907.6 EKE40105.1 - 4.8e-07 30.1 7.2 4.8e-07 30.1 7.2 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4208) DEAD PF00270.29 EKE40105.1 - 1.6e-05 24.7 0.1 7.1e-05 22.6 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase LSM PF01423.22 EKE40106.1 - 7.1e-15 54.5 0.3 8.5e-15 54.2 0.3 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EKE40106.1 - 0.00084 18.9 0.1 0.0013 18.4 0.1 1.5 1 1 0 1 1 1 1 Hfq protein FNIP PF05725.12 EKE40107.1 - 0.13 12.4 6.4 0.99 9.6 0.5 4.1 2 1 1 3 3 3 0 FNIP Repeat LRR_8 PF13855.6 EKE40107.1 - 0.19 11.5 16.6 1.1 9.1 1.2 5.3 3 1 1 4 4 4 0 Leucine rich repeat Pkinase PF00069.25 EKE40108.1 - 1.8e-44 152.1 0.2 4.5e-44 150.8 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40108.1 - 1.3e-41 142.7 0.2 2.4e-40 138.5 0.2 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase SH2 PF00017.24 EKE40108.1 - 2.7e-08 33.8 0.1 7.9e-08 32.3 0.1 1.8 1 0 0 1 1 1 1 SH2 domain Haspin_kinase PF12330.8 EKE40108.1 - 0.021 13.8 2.0 0.24 10.3 0.0 2.9 3 0 0 3 3 3 0 Haspin like kinase domain Cbl_N2 PF02761.14 EKE40108.1 - 0.087 13.5 0.2 0.087 13.5 0.2 2.6 3 0 0 3 3 3 0 CBL proto-oncogene N-terminus, EF hand-like domain APH PF01636.23 EKE40108.1 - 0.19 11.6 0.1 0.45 10.4 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family MA3 PF02847.17 EKE40109.1 - 0.83 9.7 6.1 0.61 10.1 0.3 3.9 4 0 0 4 4 4 0 MA3 domain RhoGAP PF00620.27 EKE40110.1 - 2.4e-14 53.4 2.6 3.1e-14 53.1 0.2 2.4 2 1 0 2 2 2 1 RhoGAP domain bZIP_1 PF00170.21 EKE40110.1 - 0.12 12.5 5.5 2.1 8.5 0.5 3.4 3 0 0 3 3 3 0 bZIP transcription factor Antigen_Bd37 PF11641.8 EKE40110.1 - 5.7 6.4 10.4 8.3 5.8 1.7 3.3 3 1 0 3 3 3 0 Glycosylphosphatidylinositol-anchored merozoite surface protein DEAD PF00270.29 EKE40111.1 - 6.1e-19 68.5 0.0 1.2e-18 67.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EKE40111.1 - 5.1e-05 23.3 0.0 0.00012 22.1 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 EKE40111.1 - 0.012 15.5 0.0 0.037 14.0 0.0 1.8 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EKE40111.1 - 0.024 15.0 0.0 0.055 13.8 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_26 PF13500.6 EKE40111.1 - 0.071 12.9 0.4 2.6 7.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EKE40111.1 - 0.15 12.4 0.1 1.4 9.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain MSP7_C PF12948.7 EKE40111.1 - 5.7 7.6 6.7 3.1 8.5 0.8 2.8 3 0 0 3 3 3 0 MSP7-like protein C-terminal domain Sec63 PF02889.16 EKE40113.1 - 2.8e-15 56.2 3.7 1.2e-14 54.1 3.2 1.9 2 0 0 2 2 2 1 Sec63 Brl domain Ricin_B_lectin PF00652.22 EKE40114.1 - 4e-10 40.0 0.0 5.1e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 EKE40114.1 - 5.5e-10 39.8 0.1 1.9e-05 25.3 0.0 2.3 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like VPS9 PF02204.18 EKE40115.1 - 2e-08 34.4 1.0 2e-08 34.4 1.0 2.6 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Nmad5 PF18757.1 EKE40115.1 - 0.023 14.9 3.0 0.026 14.7 0.3 2.1 1 1 1 2 2 2 0 Nucleotide modification associated domain 5 HTH_Tnp_1_2 PF13022.6 EKE40115.1 - 0.041 14.0 0.2 0.041 14.0 0.2 3.3 3 1 0 3 3 3 0 Helix-turn-helix of insertion element transposase DUF4165 PF13752.6 EKE40116.1 - 0.066 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4165) RhoGEF PF00621.20 EKE40117.1 - 2.7e-25 89.7 7.7 2.7e-25 89.7 7.7 2.6 3 0 0 3 3 3 1 RhoGEF domain SPG48 PF14764.6 EKE40117.1 - 0.0036 17.8 5.4 0.42 11.1 0.1 3.4 4 0 0 4 4 4 2 AP-5 complex subunit, vesicle trafficking Lectin_C_term PF18022.1 EKE40117.1 - 0.096 13.2 0.1 0.33 11.4 0.0 2.0 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin C-terminal domain MSP7_C PF12948.7 EKE40117.1 - 0.7 10.6 9.3 11 6.8 0.2 4.4 3 0 0 3 3 3 0 MSP7-like protein C-terminal domain FAST_1 PF06743.15 EKE40117.1 - 3.8 7.5 7.2 1.3 9.0 0.2 3.6 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 1 SF3A3 PF16837.5 EKE40117.1 - 8.6 7.0 10.3 2.2 8.9 3.6 3.2 3 1 0 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 NUC153 PF08159.12 EKE40118.1 - 3e-11 42.9 0.9 3e-11 42.9 0.9 4.5 6 0 0 6 6 6 2 NUC153 domain Metallophos PF00149.28 EKE40119.1 - 2.9e-36 125.9 0.4 3.7e-36 125.5 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EKE40119.1 - 9.4e-06 26.0 0.1 1.8e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain DUF4837 PF16125.5 EKE40120.1 - 0.038 13.0 0.7 0.077 12.0 0.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4837) Ribosomal_L33 PF00471.20 EKE40120.1 - 0.039 14.4 1.3 0.061 13.8 0.1 2.0 2 0 0 2 2 2 0 Ribosomal protein L33 tRNA-synt_1c_C PF03950.18 EKE40121.1 - 0.0021 17.9 0.2 0.0041 17.0 0.2 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain DUF5412 PF17428.2 EKE40121.1 - 0.0093 15.8 0.1 0.025 14.4 0.1 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF5412) Peptidase_C48 PF02902.19 EKE40122.1 - 1.8e-22 80.3 8.7 1.8e-22 80.3 8.7 2.3 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain NUDIX PF00293.28 EKE40123.1 - 5.7e-10 39.3 0.0 8.8e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain S4_2 PF13275.6 EKE40124.1 - 0.013 15.3 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 S4 domain BLOC1_2 PF10046.9 EKE40125.1 - 1.6e-20 73.2 6.8 2.1e-20 72.8 6.8 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 EKE40125.1 - 0.0085 16.5 3.3 0.034 14.6 0.5 2.4 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein Mannitol_dh PF01232.23 EKE40125.1 - 0.01 16.0 2.4 0.013 15.7 2.4 1.2 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain BORCS7 PF16088.5 EKE40125.1 - 0.01 16.1 3.7 0.083 13.2 0.8 2.1 1 1 0 2 2 2 0 BLOC-1-related complex sub-unit 7 Laminin_II PF06009.12 EKE40125.1 - 0.01 15.8 2.9 0.01 15.8 2.9 1.9 1 1 1 2 2 2 0 Laminin Domain II Rrn6 PF10214.9 EKE40125.1 - 0.013 14.0 2.3 0.013 14.0 2.3 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1664 PF07889.12 EKE40125.1 - 0.016 15.2 3.3 0.039 14.0 2.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) MCPsignal PF00015.21 EKE40125.1 - 0.017 14.9 2.5 0.027 14.3 2.2 1.5 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Syntaxin-6_N PF09177.11 EKE40125.1 - 0.018 15.6 2.1 0.018 15.6 2.1 1.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF3232 PF11554.8 EKE40125.1 - 0.027 14.8 3.3 0.052 13.9 3.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3232) PMC2NT PF08066.12 EKE40125.1 - 0.036 14.7 1.9 0.091 13.5 0.7 2.1 1 1 1 2 2 2 0 PMC2NT (NUC016) domain APG6_N PF17675.1 EKE40125.1 - 0.054 14.0 5.7 0.038 14.5 4.6 1.3 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF3450 PF11932.8 EKE40125.1 - 0.096 12.0 7.4 0.022 14.1 3.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) S-AdoMet_synt_M PF02772.16 EKE40125.1 - 0.1 12.8 1.1 0.12 12.6 1.1 1.3 1 1 0 1 1 1 0 S-adenosylmethionine synthetase, central domain Prefoldin_2 PF01920.20 EKE40125.1 - 0.12 12.4 0.5 0.12 12.4 0.5 2.8 1 1 1 2 2 2 0 Prefoldin subunit Fib_alpha PF08702.10 EKE40125.1 - 0.13 12.5 8.7 0.2 11.9 7.1 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family KxDL PF10241.9 EKE40125.1 - 0.19 12.0 6.4 1 9.7 1.8 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein Seryl_tRNA_N PF02403.22 EKE40125.1 - 0.4 10.9 7.7 0.35 11.1 3.4 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Phasin_2 PF09361.10 EKE40125.1 - 0.48 10.7 5.8 0.48 10.7 2.3 2.6 2 1 0 2 2 2 0 Phasin protein FlaC_arch PF05377.11 EKE40125.1 - 1.3 9.5 10.0 3.5 8.1 0.6 3.4 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) zf-C4H2 PF10146.9 EKE40125.1 - 1.9 8.7 7.0 2.8 8.2 1.0 2.1 1 1 1 2 2 2 0 Zinc finger-containing protein PPC PF04151.15 EKE40126.1 - 0.0019 19.3 14.4 0.13 13.4 0.1 4.7 4 0 0 4 4 4 2 Bacterial pre-peptidase C-terminal domain DUF2244 PF10003.9 EKE40126.1 - 0.26 11.0 0.6 1.7 8.3 1.6 1.8 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) RhoGAP PF00620.27 EKE40127.1 - 2.6e-21 76.0 3.7 3.4e-21 75.7 0.6 2.4 2 0 0 2 2 2 1 RhoGAP domain Retrotrans_gag PF03732.17 EKE40127.1 - 0.53 10.6 2.2 7.6 6.9 0.2 2.7 2 0 0 2 2 2 0 Retrotransposon gag protein Antigen_Bd37 PF11641.8 EKE40128.1 - 0.031 13.8 5.5 0.083 12.4 5.5 1.7 1 1 0 1 1 1 0 Glycosylphosphatidylinositol-anchored merozoite surface protein RasGEF PF00617.19 EKE40129.1 - 1.2e-08 35.4 6.0 2.1e-08 34.6 5.6 1.7 1 1 0 1 1 1 1 RasGEF domain Pkinase_Tyr PF07714.17 EKE40130.1 - 1.3e-36 126.3 0.0 2.3e-36 125.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40130.1 - 1e-27 97.2 0.0 2.9e-27 95.7 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain LRR_8 PF13855.6 EKE40130.1 - 4.4e-16 58.4 18.4 6.8e-07 29.0 2.8 4.4 3 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EKE40130.1 - 1.2e-08 35.1 38.4 1e-06 28.9 2.0 6.4 4 2 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EKE40130.1 - 2.4e-06 27.3 15.2 1.4 9.7 0.4 8.5 7 2 1 8 8 8 2 Leucine Rich Repeat Myotub-related PF06602.14 EKE40130.1 - 4.1e-05 22.7 8.4 0.00028 20.0 2.9 2.8 2 1 0 2 2 2 1 Myotubularin-like phosphatase domain RhoGAP PF00620.27 EKE40130.1 - 0.014 15.2 1.2 0.18 11.6 0.1 3.0 3 0 0 3 3 3 0 RhoGAP domain Kdo PF06293.14 EKE40130.1 - 0.017 14.5 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_6 PF13516.6 EKE40130.1 - 0.062 13.4 25.5 4.9 7.5 0.5 7.9 8 0 0 8 8 8 0 Leucine Rich repeat SAM_2 PF07647.17 EKE40130.1 - 0.14 12.3 0.7 0.5 10.5 0.7 2.1 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF3819 PF12842.7 EKE40131.1 - 0.13 12.2 0.1 0.32 10.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) DUF4100 PF13352.6 EKE40131.1 - 0.16 11.7 0.1 0.37 10.5 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4100) HMG_box PF00505.19 EKE40132.1 - 1.3e-23 83.2 2.5 1.6e-23 82.9 2.5 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EKE40132.1 - 1e-11 45.2 2.0 1.4e-11 44.8 2.0 1.2 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 EKE40132.1 - 8.1e-06 25.7 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 CHDNT (NUC034) domain Rax2 PF12768.7 EKE40132.1 - 0.022 14.2 0.2 0.024 14.1 0.2 1.0 1 0 0 1 1 1 0 Cortical protein marker for cell polarity FH2 PF02181.23 EKE40134.1 - 2.9e-15 56.3 9.4 7e-15 55.0 4.7 4.1 3 2 0 3 3 3 2 Formin Homology 2 Domain DUF2250 PF10007.9 EKE40134.1 - 0.015 15.4 2.5 0.019 15.1 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) Cep57_CLD_2 PF14197.6 EKE40134.1 - 0.021 14.9 0.8 0.021 14.9 0.8 2.8 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 CALCOCO1 PF07888.11 EKE40134.1 - 2.5 6.9 24.0 1.2 7.9 0.3 3.2 2 1 1 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4140 PF13600.6 EKE40134.1 - 4.5 7.8 5.4 4 7.9 0.5 2.8 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Myb_DNA-bind_3 PF12776.7 EKE40134.1 - 5.6 8.0 8.3 15 6.7 0.3 3.3 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain DUF4407 PF14362.6 EKE40134.1 - 6.4 6.0 8.3 13 5.0 8.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) E1_UFD PF09358.10 EKE40134.1 - 7.3 7.4 9.1 2.5 8.8 1.7 3.1 1 1 0 2 2 2 0 Ubiquitin fold domain Ribosomal_L29 PF00831.23 EKE40134.1 - 8.4 6.5 10.8 2.6 8.1 0.7 4.5 4 0 0 4 4 4 0 Ribosomal L29 protein Tup_N PF08581.10 EKE40135.1 - 2.6e-05 24.4 11.9 3.9e-05 23.9 11.9 1.3 1 0 0 1 1 1 1 Tup N-terminal BLOC1_2 PF10046.9 EKE40135.1 - 0.00019 21.7 8.4 0.00024 21.3 8.4 1.3 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 EzrA PF06160.12 EKE40135.1 - 0.00026 19.3 9.8 0.0003 19.1 9.8 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF3450 PF11932.8 EKE40135.1 - 0.00036 19.9 9.7 0.00048 19.5 9.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) TACC_C PF05010.14 EKE40135.1 - 0.00084 19.2 8.7 0.0012 18.7 8.7 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TPR_MLP1_2 PF07926.12 EKE40135.1 - 0.0017 18.4 11.0 0.002 18.2 11.0 1.1 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein ZapB PF06005.12 EKE40135.1 - 0.002 18.6 7.8 0.002 18.6 7.8 2.1 1 1 1 2 2 2 1 Cell division protein ZapB DUF812 PF05667.11 EKE40135.1 - 0.0024 16.8 8.6 0.0034 16.4 8.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Fib_alpha PF08702.10 EKE40135.1 - 0.0031 17.7 10.4 0.0062 16.7 10.4 1.5 1 1 0 1 1 1 1 Fibrinogen alpha/beta chain family IFT57 PF10498.9 EKE40135.1 - 0.0038 16.3 10.5 0.0044 16.0 10.5 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 TMF_DNA_bd PF12329.8 EKE40135.1 - 0.0055 16.7 11.4 0.0069 16.4 3.6 2.0 1 1 1 2 2 2 1 TATA element modulatory factor 1 DNA binding Fez1 PF06818.15 EKE40135.1 - 0.0065 17.0 7.6 0.0074 16.8 7.6 1.1 1 0 0 1 1 1 1 Fez1 DHR10 PF18595.1 EKE40135.1 - 0.0069 16.4 12.0 0.012 15.7 12.0 1.4 1 1 0 1 1 1 1 Designed helical repeat protein 10 domain Jnk-SapK_ap_N PF09744.9 EKE40135.1 - 0.01 16.1 10.4 0.012 15.9 10.4 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 APG6_N PF17675.1 EKE40135.1 - 0.01 16.3 12.7 0.016 15.8 12.7 1.3 1 1 0 1 1 1 0 Apg6 coiled-coil region ERM PF00769.19 EKE40135.1 - 0.012 15.5 11.9 0.013 15.4 11.9 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family SLATT_1 PF18181.1 EKE40135.1 - 0.012 15.6 2.2 0.015 15.2 2.2 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 PI3K_P85_iSH2 PF16454.5 EKE40135.1 - 0.014 15.0 10.2 0.028 14.0 10.2 1.5 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Cluap1 PF10234.9 EKE40135.1 - 0.014 14.8 9.8 0.017 14.5 9.8 1.0 1 0 0 1 1 1 0 Clusterin-associated protein-1 FliD_N PF02465.18 EKE40135.1 - 0.015 15.9 2.2 0.015 15.9 2.2 1.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF1664 PF07889.12 EKE40135.1 - 0.018 15.1 6.0 0.023 14.7 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EKE40135.1 - 0.018 14.0 11.2 0.02 13.8 11.2 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF724 PF05266.14 EKE40135.1 - 0.019 14.8 7.6 0.023 14.5 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Bap31_Bap29_C PF18035.1 EKE40135.1 - 0.021 14.8 6.8 0.032 14.2 6.5 1.5 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain ECH_1 PF00378.20 EKE40135.1 - 0.022 14.1 0.9 0.027 13.8 0.9 1.3 1 1 0 1 1 1 0 Enoyl-CoA hydratase/isomerase FIVAR PF07554.13 EKE40135.1 - 0.024 15.4 5.4 0.043 14.6 5.4 1.4 1 1 0 1 1 1 0 FIVAR domain Noelin-1 PF12308.8 EKE40135.1 - 0.028 14.4 2.6 0.043 13.8 2.4 1.4 1 1 0 1 1 1 0 Neurogenesis glycoprotein APG17 PF04108.12 EKE40135.1 - 0.028 13.5 6.8 0.033 13.3 6.8 1.0 1 0 0 1 1 1 0 Autophagy protein Apg17 AAA_13 PF13166.6 EKE40135.1 - 0.03 13.0 10.8 0.032 12.9 10.8 1.0 1 0 0 1 1 1 0 AAA domain CLZ PF16526.5 EKE40135.1 - 0.031 14.6 6.5 0.89 10.0 0.7 2.5 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Laminin_II PF06009.12 EKE40135.1 - 0.033 14.2 5.7 0.056 13.5 5.7 1.4 1 1 0 1 1 1 0 Laminin Domain II ABC_tran_Xtn PF12848.7 EKE40135.1 - 0.034 14.2 8.5 0.033 14.2 7.4 1.6 1 1 0 1 1 1 0 ABC transporter DUF4618 PF15397.6 EKE40135.1 - 0.034 13.6 9.2 0.52 9.7 3.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) MerR-DNA-bind PF09278.11 EKE40135.1 - 0.037 14.6 5.9 0.04 14.5 0.8 2.2 1 1 1 2 2 2 0 MerR, DNA binding 4HB_MCP_1 PF12729.7 EKE40135.1 - 0.037 13.6 5.2 0.021 14.4 2.2 1.8 1 1 1 2 2 2 0 Four helix bundle sensory module for signal transduction BRE1 PF08647.11 EKE40135.1 - 0.039 14.0 10.3 0.12 12.4 10.3 1.7 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase SAS4 PF15460.6 EKE40135.1 - 0.041 14.0 7.2 0.055 13.6 7.2 1.2 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 CENP-F_leu_zip PF10473.9 EKE40135.1 - 0.042 13.9 10.6 0.062 13.3 10.6 1.3 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 PF09787.9 EKE40135.1 - 0.045 13.2 12.8 0.045 13.2 12.8 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 ADIP PF11559.8 EKE40135.1 - 0.045 13.8 11.5 0.08 13.0 9.0 1.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Tektin PF03148.14 EKE40135.1 - 0.059 12.1 12.5 0.33 9.6 12.5 1.8 1 1 0 1 1 1 0 Tektin family Sec34 PF04136.15 EKE40135.1 - 0.059 13.2 6.7 0.15 12.0 3.7 1.9 1 1 1 2 2 2 0 Sec34-like family Snf7 PF03357.21 EKE40135.1 - 0.067 12.8 11.9 0.067 12.8 2.5 2.0 2 0 0 2 2 2 0 Snf7 Muted PF14942.6 EKE40135.1 - 0.074 13.4 11.5 0.082 13.2 11.5 1.0 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein THP2 PF09432.10 EKE40135.1 - 0.078 13.0 4.3 0.09 12.8 4.3 1.1 1 0 0 1 1 1 0 Tho complex subunit THP2 DUF745 PF05335.13 EKE40135.1 - 0.084 12.6 7.4 0.1 12.3 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF948 PF06103.11 EKE40135.1 - 0.086 13.1 1.6 0.22 11.8 1.4 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Syntaxin_2 PF14523.6 EKE40135.1 - 0.096 13.1 8.9 0.16 12.3 7.7 1.8 1 1 1 2 2 2 0 Syntaxin-like protein HIP1_clath_bdg PF16515.5 EKE40135.1 - 0.096 13.3 9.4 0.17 12.5 9.4 1.4 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 GrpE PF01025.19 EKE40135.1 - 0.12 12.0 12.3 0.37 10.4 4.9 2.0 1 1 1 2 2 2 0 GrpE TRAF_BIRC3_bd PF16673.5 EKE40135.1 - 0.13 12.1 8.1 0.083 12.7 2.9 2.1 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DUF4709 PF15821.5 EKE40135.1 - 0.13 12.5 7.1 0.2 11.9 7.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4709) HAUS6_N PF14661.6 EKE40135.1 - 0.14 11.7 9.4 0.47 10.0 9.4 1.7 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF4404 PF14357.6 EKE40135.1 - 0.14 12.8 4.5 0.26 11.9 4.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) Baculo_PEP_C PF04513.12 EKE40135.1 - 0.15 12.1 3.5 0.33 11.0 3.5 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus WXG100 PF06013.12 EKE40135.1 - 0.16 12.2 5.4 0.56 10.5 0.5 2.3 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Prefoldin_2 PF01920.20 EKE40135.1 - 0.16 11.9 12.4 0.65 10.0 0.5 2.4 1 1 2 3 3 3 0 Prefoldin subunit CENP-H PF05837.12 EKE40135.1 - 0.17 12.3 8.4 0.066 13.6 4.5 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) V-ATPase_C PF03223.15 EKE40135.1 - 0.17 11.3 5.5 0.16 11.3 2.8 1.8 1 1 1 2 2 2 0 V-ATPase subunit C DUF2203 PF09969.9 EKE40135.1 - 0.18 12.6 4.4 0.24 12.1 4.4 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) EZH2_WD-Binding PF11616.8 EKE40135.1 - 0.18 11.9 0.5 0.18 11.9 0.5 2.1 2 0 0 2 2 2 0 WD repeat binding protein EZH2 TMPIT PF07851.13 EKE40135.1 - 0.2 10.9 9.2 0.22 10.7 9.2 1.0 1 0 0 1 1 1 0 TMPIT-like protein LOH1CR12 PF10158.9 EKE40135.1 - 0.21 11.6 5.3 0.5 10.4 4.1 1.8 1 1 1 2 2 2 0 Tumour suppressor protein Phage_GPO PF05929.11 EKE40135.1 - 0.24 11.0 6.2 0.26 10.9 6.2 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4298 PF14131.6 EKE40135.1 - 0.25 11.3 9.1 1.3 9.0 7.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4298) V_ATPase_I PF01496.19 EKE40135.1 - 0.28 9.0 6.4 0.29 9.0 6.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FUSC PF04632.12 EKE40135.1 - 0.3 9.6 0.8 0.36 9.3 0.8 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family XhlA PF10779.9 EKE40135.1 - 0.3 11.3 7.2 0.18 12.0 1.7 2.2 1 1 1 2 2 2 0 Haemolysin XhlA Atg14 PF10186.9 EKE40135.1 - 0.31 10.1 9.1 0.34 9.9 9.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PEP-utilisers_N PF05524.13 EKE40135.1 - 0.31 11.2 6.7 0.63 10.2 2.6 2.0 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal THOC7 PF05615.13 EKE40135.1 - 0.31 11.3 12.6 9.6 6.5 12.6 2.0 1 1 0 1 1 1 0 Tho complex subunit 7 Trimer_CC PF08954.11 EKE40135.1 - 0.33 10.5 6.7 2.5 7.7 1.3 2.7 2 1 0 2 2 2 0 Trimerisation motif CREPT PF16566.5 EKE40135.1 - 0.38 10.9 7.3 0.43 10.8 7.3 1.1 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Myb_DNA-bind_4 PF13837.6 EKE40135.1 - 0.38 11.2 4.4 0.47 10.9 4.4 1.3 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF4407 PF14362.6 EKE40135.1 - 0.4 10.0 8.2 0.51 9.6 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YlqD PF11068.8 EKE40135.1 - 0.41 11.0 13.1 2.5 8.5 13.1 1.9 1 1 0 1 1 1 0 YlqD protein Macoilin PF09726.9 EKE40135.1 - 0.44 9.1 8.5 0.48 8.9 8.5 1.0 1 0 0 1 1 1 0 Macoilin family OmpH PF03938.14 EKE40135.1 - 0.46 10.8 13.5 0.91 9.9 13.3 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 EKE40135.1 - 0.57 9.7 7.6 0.61 9.6 7.6 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit 5_nucleotid PF05761.14 EKE40135.1 - 0.6 8.9 7.5 0.65 8.8 7.5 1.0 1 0 0 1 1 1 0 5' nucleotidase family ABC_tran_CTD PF16326.5 EKE40135.1 - 0.69 10.2 11.8 0.66 10.3 4.2 2.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain FlaC_arch PF05377.11 EKE40135.1 - 0.73 10.3 7.4 15 6.1 0.3 3.0 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DUF5082 PF16888.5 EKE40135.1 - 0.79 10.0 13.7 6.9 7.0 7.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) DivIC PF04977.15 EKE40135.1 - 0.91 9.3 15.9 0.98 9.2 3.6 2.6 1 1 2 3 3 3 0 Septum formation initiator DUF16 PF01519.16 EKE40135.1 - 0.98 9.9 10.2 8.8 6.9 10.0 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 HALZ PF02183.18 EKE40135.1 - 1 9.6 8.3 5 7.4 0.8 2.7 2 1 1 3 3 2 0 Homeobox associated leucine zipper eIF-4B PF06273.11 EKE40135.1 - 1 8.3 6.6 1.1 8.2 6.6 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B DUF1192 PF06698.11 EKE40135.1 - 1.2 9.3 9.2 19 5.4 0.4 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1192) FapA PF03961.13 EKE40135.1 - 1.5 7.4 9.6 1.6 7.2 9.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-C4H2 PF10146.9 EKE40135.1 - 1.5 9.1 10.2 1.8 8.8 10.2 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein IFP_35_N PF07334.13 EKE40135.1 - 1.7 8.7 9.9 14 5.8 0.1 2.6 2 1 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Rho_Binding PF08912.11 EKE40135.1 - 1.9 9.4 13.1 1.5 9.7 6.8 2.1 1 1 1 2 2 2 0 Rho Binding UPF0242 PF06785.11 EKE40135.1 - 2 8.5 13.5 2.4 8.2 13.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DASH_Spc34 PF08657.10 EKE40135.1 - 2 8.2 11.4 3.2 7.5 11.4 1.4 1 1 0 1 1 1 0 DASH complex subunit Spc34 DUF4140 PF13600.6 EKE40135.1 - 2.9 8.4 8.6 13 6.3 8.6 1.9 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Spc24 PF08286.11 EKE40135.1 - 3.3 8.0 10.6 5 7.4 4.1 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 LPP PF04728.13 EKE40135.1 - 7.2 7.1 10.5 16 6.0 2.8 2.3 1 1 1 2 2 2 0 Lipoprotein leucine-zipper Osmo_CC PF08946.10 EKE40135.1 - 9 6.6 12.8 1.7 8.9 0.5 3.1 1 1 2 3 3 3 0 Osmosensory transporter coiled coil PH_11 PF15413.6 EKE40136.1 - 8.5 6.9 8.5 2 8.9 0.8 3.5 3 0 0 3 3 3 0 Pleckstrin homology domain EC042_2821 PF18740.1 EKE40138.1 - 0.0086 16.0 0.1 0.017 15.0 0.1 1.4 1 0 0 1 1 1 1 EC042_2821-lke REase Sec16_C PF12931.7 EKE40139.1 - 4.6e-10 39.6 3.2 1.5e-08 34.6 1.8 2.9 1 1 1 2 2 2 2 Sec23-binding domain of Sec16 ANAPC4_WD40 PF12894.7 EKE40139.1 - 5.7e-09 36.2 3.9 0.087 13.1 0.0 5.7 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EKE40139.1 - 2e-05 25.3 0.3 0.28 12.1 0.0 4.5 5 0 0 5 5 5 1 WD domain, G-beta repeat A_thal_3526 PF09713.10 EKE40140.1 - 0.034 14.4 0.1 0.075 13.3 0.1 1.5 1 0 0 1 1 1 0 Plant protein 1589 of unknown function (A_thal_3526) DUF2207 PF09972.9 EKE40140.1 - 0.084 11.6 0.0 0.084 11.6 0.0 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) zf-RING_5 PF14634.6 EKE40141.1 - 0.012 15.5 15.2 0.034 14.1 15.3 1.7 1 1 0 1 1 1 0 zinc-RING finger domain XRN_N PF03159.18 EKE40141.1 - 0.027 13.9 0.8 0.035 13.5 0.8 1.2 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus zf-Mss51 PF13824.6 EKE40141.1 - 0.04 14.0 2.5 0.092 12.9 2.5 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Prok-RING_4 PF14447.6 EKE40141.1 - 0.051 13.4 10.1 0.098 12.5 10.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Herpes_UL25 PF01499.16 EKE40141.1 - 0.07 11.6 0.2 0.093 11.2 0.2 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family zf_UBZ PF18439.1 EKE40141.1 - 0.32 10.6 0.2 0.32 10.6 0.2 2.6 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger DUF573 PF04504.14 EKE40141.1 - 0.82 10.4 6.6 7.5 7.3 0.1 2.6 1 1 1 2 2 2 0 Protein of unknown function, DUF573 Prok-RING_2 PF14445.6 EKE40141.1 - 0.98 9.6 6.8 2.3 8.5 6.7 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 2 zf-RING_2 PF13639.6 EKE40141.1 - 1.7 9.0 13.1 3 8.3 13.1 1.4 1 0 0 1 1 1 0 Ring finger domain DZR PF12773.7 EKE40141.1 - 2.7 8.1 10.2 7.6 6.6 10.2 1.7 1 1 0 1 1 1 0 Double zinc ribbon RNA_pol_Rpb5_N PF03871.14 EKE40142.1 - 0.44 11.1 3.1 0.26 11.9 0.5 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb5, N-terminal domain BORCS6 PF10157.9 EKE40143.1 - 0.00059 20.1 0.3 0.00081 19.6 0.3 1.3 1 1 0 1 1 1 1 BLOC-1-related complex sub-unit 6 HECT PF00632.25 EKE40147.1 - 7.2e-75 252.3 3.8 3e-74 250.3 3.8 2.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) FemAB_like PF04339.12 EKE40147.1 - 0.02 14.0 0.2 0.059 12.5 0.1 1.8 2 0 0 2 2 2 0 Peptidogalycan biosysnthesis/recognition Vps26 PF03643.15 EKE40148.1 - 2e-44 151.7 0.8 2.5e-44 151.3 0.8 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EKE40148.1 - 0.035 14.2 0.1 0.15 12.1 0.1 2.1 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.10 EKE40148.1 - 1.1 8.4 5.7 1.4 8.0 0.1 2.8 3 1 0 3 3 3 0 Rgp1 RasGAP PF00616.19 EKE40149.1 - 4e-10 39.7 0.5 4e-10 39.7 0.5 3.3 2 2 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase MGC-24 PF05283.11 EKE40150.1 - 0.00019 21.9 0.4 0.00097 19.6 0.1 2.1 2 0 0 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin TMEM154 PF15102.6 EKE40150.1 - 0.00097 19.1 0.7 0.0026 17.6 0.7 1.7 1 0 0 1 1 1 1 TMEM154 protein family Mid2 PF04478.12 EKE40150.1 - 0.0048 16.8 0.8 0.025 14.4 0.2 2.3 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor Podoplanin PF05808.11 EKE40150.1 - 0.0051 16.9 0.2 0.012 15.8 0.2 1.6 1 0 0 1 1 1 1 Podoplanin Pox_A14 PF05767.12 EKE40150.1 - 0.016 15.3 0.1 0.034 14.3 0.1 1.5 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 Plasmodium_Vir PF05795.11 EKE40150.1 - 0.035 13.5 0.3 0.055 12.9 0.3 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Syndecan PF01034.20 EKE40150.1 - 0.051 13.5 3.4 0.14 12.1 3.4 1.7 1 0 0 1 1 1 0 Syndecan domain NusG_II PF07009.11 EKE40150.1 - 0.064 13.5 0.2 0.064 13.5 0.2 2.4 2 0 0 2 2 2 0 NusG domain II EVI2A PF05399.11 EKE40150.1 - 0.073 12.7 0.8 0.14 11.8 0.8 1.4 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) EphA2_TM PF14575.6 EKE40150.1 - 0.078 13.9 1.0 0.2 12.6 1.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 EKE40150.1 - 0.11 12.9 0.0 0.24 11.7 0.0 1.7 1 0 0 1 1 1 0 Orf78 (ac78) DUF1180 PF06679.12 EKE40150.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Adeno_E3_CR2 PF02439.15 EKE40150.1 - 0.31 10.8 5.4 0.6 9.9 5.4 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Insulin_TMD PF17870.1 EKE40150.1 - 0.38 10.9 5.7 0.34 11.0 3.8 1.9 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment PhoLip_ATPase_C PF16212.5 EKE40151.1 - 8.4e-31 107.6 16.7 8.4e-31 107.6 16.7 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal E1-E2_ATPase PF00122.20 EKE40151.1 - 5.5e-16 58.6 1.0 1.7e-15 57.1 1.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase PhoLip_ATPase_N PF16209.5 EKE40151.1 - 8.4e-15 54.2 5.0 8.4e-15 54.2 5.0 3.1 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EKE40151.1 - 6e-13 48.7 0.1 6e-12 45.5 0.1 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EKE40151.1 - 2e-11 44.6 0.1 6.8e-09 36.3 0.1 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4392 PF14336.6 EKE40151.1 - 0.013 15.0 0.2 0.029 13.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) PAP2 PF01569.21 EKE40152.1 - 2.2e-23 82.5 5.6 2.2e-23 82.5 5.6 1.9 1 1 1 2 2 2 1 PAP2 superfamily DUF4293 PF14126.6 EKE40152.1 - 0.057 13.7 1.8 0.92 9.8 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) Ndc1_Nup PF09531.10 EKE40152.1 - 0.25 10.0 4.2 0.3 9.7 4.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4131 PF13567.6 EKE40152.1 - 0.68 9.6 2.3 1.2 8.8 1.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF1980 PF09323.10 EKE40152.1 - 4.7 7.1 7.3 0.97 9.3 1.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1980) PDR_CDR PF06422.12 EKE40152.1 - 5.6 6.9 5.9 1.1 9.2 0.1 2.5 3 0 0 3 3 3 0 CDR ABC transporter DUF3671 PF12420.8 EKE40152.1 - 7.7 6.6 10.3 0.89 9.6 3.6 2.3 2 1 0 2 2 2 0 Protein of unknown function RabGAP-TBC PF00566.18 EKE40153.1 - 1.4e-32 113.1 9.3 1.4e-32 113.1 9.3 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF4116 PF13475.6 EKE40153.1 - 0.0029 17.3 1.2 0.029 14.1 0.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4116) ALIX_LYPXL_bnd PF13949.6 EKE40154.1 - 2.8e-34 118.8 27.0 3.8e-34 118.3 24.5 2.3 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV OmpH PF03938.14 EKE40154.1 - 0.1 12.9 33.0 0.082 13.2 5.5 3.7 4 0 0 4 4 4 0 Outer membrane protein (OmpH-like) DUF2353 PF09789.9 EKE40154.1 - 0.17 11.2 31.9 0.024 14.0 8.4 2.5 1 1 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) EzrA PF06160.12 EKE40154.1 - 0.59 8.2 52.3 0.016 13.4 29.3 2.8 2 1 0 3 3 3 0 Septation ring formation regulator, EzrA YabA PF06156.13 EKE40154.1 - 1.3 9.7 30.0 0.71 10.5 5.2 4.0 3 0 0 3 3 3 0 Initiation control protein YabA CPT PF07931.12 EKE40155.1 - 0.062 13.1 0.0 0.08 12.8 0.0 1.2 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein START PF01852.19 EKE40156.1 - 3.7e-16 59.2 0.0 4.5e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 START domain TLD PF07534.16 EKE40157.1 - 1.3e-07 31.9 2.2 2e-07 31.3 2.2 1.2 1 0 0 1 1 1 1 TLD FlaC_arch PF05377.11 EKE40157.1 - 0.032 14.6 1.3 0.066 13.6 1.3 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Rxt3 PF08642.10 EKE40157.1 - 0.041 14.6 0.0 0.16 12.8 0.0 1.8 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 XhlA PF10779.9 EKE40157.1 - 0.073 13.3 1.7 0.37 11.0 1.5 2.2 2 1 0 2 2 2 0 Haemolysin XhlA Dynamin_N PF00350.23 EKE40158.1 - 9.2e-35 120.2 0.0 9.2e-35 120.2 0.0 3.4 4 1 0 4 4 4 1 Dynamin family MMR_HSR1 PF01926.23 EKE40158.1 - 9.5e-07 28.9 0.0 7.4e-06 26.0 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase TipAS PF07739.13 EKE40158.1 - 0.24 12.0 4.5 0.56 10.8 3.2 2.4 1 1 0 1 1 1 0 TipAS antibiotic-recognition domain DUF3523 PF12037.8 EKE40159.1 - 0.0085 15.5 3.1 0.011 15.1 3.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) SET PF00856.28 EKE40161.1 - 1.2e-12 48.5 0.1 3.2e-12 47.2 0.0 1.7 2 0 0 2 2 2 1 SET domain DUF1679 PF07914.11 EKE40161.1 - 0.071 12.0 0.8 0.12 11.2 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DUF3137 PF11335.8 EKE40162.1 - 0.053 13.5 0.2 1.8 8.5 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3137) LIM PF00412.22 EKE40163.1 - 4.4e-20 71.7 20.4 2e-11 43.9 4.2 2.5 2 1 0 2 2 2 2 LIM domain Zn_Tnp_IS1595 PF12760.7 EKE40163.1 - 0.025 14.6 4.0 0.025 14.6 4.0 3.6 2 1 2 4 4 4 0 Transposase zinc-ribbon domain Rad50_zn_hook PF04423.14 EKE40163.1 - 0.035 13.9 0.1 0.035 13.9 0.1 3.0 4 0 0 4 4 4 0 Rad50 zinc hook motif zf-ACC PF17848.1 EKE40163.1 - 0.18 11.9 0.1 0.18 11.9 0.1 4.9 5 1 0 5 5 5 0 Acetyl-coA carboxylase zinc finger domain DZR PF12773.7 EKE40163.1 - 0.27 11.3 23.2 30 4.8 8.0 3.8 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 EKE40163.1 - 0.35 10.7 21.0 1.4 8.8 1.7 5.1 3 2 0 3 3 3 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 EKE40163.1 - 0.46 10.0 0.2 0.46 10.0 0.2 5.4 6 1 0 6 6 6 0 zinc-ribbon domain zf-dskA_traR PF01258.17 EKE40163.1 - 0.54 10.3 28.8 1.2 9.2 4.8 5.2 5 1 0 5 5 5 0 Prokaryotic dksA/traR C4-type zinc finger RecO_C PF02565.15 EKE40163.1 - 0.71 9.6 8.6 0.26 11.1 0.5 2.3 2 0 0 2 2 2 0 Recombination protein O C terminal DUF3797 PF12677.7 EKE40163.1 - 3.6 7.6 19.2 1.8 8.5 6.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF3797) Desulfoferrod_N PF06397.12 EKE40163.1 - 5.4 6.7 17.6 0.82 9.3 0.6 4.0 3 1 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain zf_UBZ PF18439.1 EKE40163.1 - 7.5 6.2 22.7 1.2 8.8 0.7 4.4 4 1 0 4 4 4 0 Ubiquitin-Binding Zinc Finger DUF4455 PF14643.6 EKE40164.1 - 0.0042 15.8 2.3 0.0068 15.1 0.5 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4455) FliJ PF02050.16 EKE40164.1 - 0.026 14.8 0.7 0.096 12.9 0.1 2.0 2 0 0 2 2 2 0 Flagellar FliJ protein SAT PF16073.5 EKE40164.1 - 0.14 11.9 0.2 0.24 11.1 0.0 1.4 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis ARL2_Bind_BART PF11527.8 EKE40164.1 - 0.16 12.1 2.8 0.49 10.5 2.8 1.9 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART Swi5 PF07061.11 EKE40164.1 - 0.3 11.2 3.2 2.3 8.4 3.2 2.2 1 1 0 1 1 1 0 Swi5 DUF5595 PF18077.1 EKE40164.1 - 2.4 8.3 6.9 3.2 7.9 3.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5595) UCH PF00443.29 EKE40165.1 - 4e-27 95.3 9.9 2.5e-26 92.7 9.9 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE40165.1 - 9.4e-08 32.0 23.0 0.00011 22.0 10.9 4.0 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase DSPc PF00782.20 EKE40166.1 - 8.6e-29 100.0 0.2 1.2e-28 99.6 0.2 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EKE40166.1 - 0.00075 19.1 0.0 0.00097 18.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 EKE40166.1 - 0.033 13.8 0.1 0.058 13.0 0.1 1.7 1 1 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EKE40166.1 - 0.047 13.8 0.0 0.096 12.8 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate Peptidase_M15_4 PF13539.6 EKE40166.1 - 0.097 13.2 0.1 0.24 11.9 0.1 1.8 1 1 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase MitoNEET_N PF10660.9 EKE40166.1 - 0.2 11.7 0.5 5.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus DUF2846 PF11008.8 EKE40167.1 - 0.13 12.3 0.3 2.1 8.4 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2846) Glyco_hydro_2 PF00703.21 EKE40167.1 - 0.16 12.7 0.0 0.55 10.9 0.0 1.9 1 0 0 1 1 1 0 Glycosyl hydrolases family 2 ATP-synt_C PF00137.21 EKE40168.1 - 6.3e-30 103.3 30.8 4.7e-20 71.7 11.8 2.2 2 0 0 2 2 2 2 ATP synthase subunit C DOT1 PF08123.13 EKE40168.1 - 0.12 11.9 0.2 0.15 11.5 0.2 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 NapE PF06796.11 EKE40168.1 - 0.32 10.5 5.5 1.2 8.7 2.9 2.4 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE Pkinase PF00069.25 EKE40169.1 - 1.6e-79 267.0 0.0 2.3e-79 266.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40169.1 - 2.9e-35 121.8 0.0 4.7e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EKE40169.1 - 5.8e-11 42.6 0.2 1.6e-10 41.1 0.2 1.8 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 EKE40169.1 - 3.1e-05 23.4 0.0 5.9e-05 22.5 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKE40169.1 - 0.0003 20.2 0.2 0.00095 18.6 0.1 1.7 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EKE40169.1 - 0.0017 17.4 0.7 0.0027 16.7 0.7 1.2 1 0 0 1 1 1 1 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 EKE40169.1 - 0.03 13.8 0.1 0.053 13.0 0.1 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 EKE40169.1 - 0.084 12.5 0.1 2.7 7.6 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 WD40 PF00400.32 EKE40170.1 - 1.4e-12 47.9 6.3 0.052 14.4 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE40170.1 - 1.3e-06 28.6 0.1 2.4 8.5 0.0 4.9 2 1 3 6 6 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EKE40170.1 - 6.5e-06 25.7 1.0 1.4e-05 24.6 0.8 1.6 1 1 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 EKE40170.1 - 0.025 13.5 0.9 0.62 9.0 0.1 3.0 2 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 EKE40170.1 - 0.048 13.7 0.1 0.13 12.3 0.1 1.8 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region ELYS-bb PF16687.5 EKE40170.1 - 0.089 11.4 0.1 1 7.9 0.0 2.2 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin HECT PF00632.25 EKE40171.1 - 5.4e-88 295.4 0.9 9.6e-88 294.6 0.9 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EKE40171.1 - 1.9e-05 24.8 2.5 4e-05 23.8 2.5 1.5 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A DUF996 PF06195.13 EKE40173.1 - 0.087 13.1 2.9 0.14 12.4 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF996) DUF1516 PF07457.11 EKE40173.1 - 0.095 12.9 1.7 0.15 12.2 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1516) RIC1 PF07064.13 EKE40174.1 - 2.1e-09 37.2 0.1 3.8e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 RIC1 MutS_III PF05192.18 EKE40175.1 - 0.017 15.4 2.9 0.023 14.9 2.9 1.2 1 0 0 1 1 1 0 MutS domain III FliJ PF02050.16 EKE40175.1 - 0.032 14.5 1.5 0.067 13.4 1.5 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein DNA_repr_REX1B PF14966.6 EKE40175.1 - 0.035 14.8 4.6 0.078 13.6 4.6 1.6 1 0 0 1 1 1 0 DNA repair REX1-B FUSC-like PF12805.7 EKE40175.1 - 0.089 11.9 0.3 0.13 11.3 0.3 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS MyTH4 PF00784.17 EKE40175.1 - 0.099 13.1 2.2 0.18 12.3 0.1 2.3 2 1 0 2 2 2 0 MyTH4 domain AvrM-A PF18241.1 EKE40175.1 - 0.15 12.5 0.3 0.15 12.5 0.3 2.5 2 0 0 2 2 2 0 Flax-rust effector AvrM-A ETC_C1_NDUFA5 PF04716.14 EKE40175.1 - 0.72 9.7 4.1 0.88 9.4 1.7 2.4 2 0 0 2 2 2 0 ETC complex I subunit conserved region DUF3368 PF11848.8 EKE40176.1 - 0.15 11.9 0.4 2.1 8.2 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3368) Rad51 PF08423.11 EKE40177.1 - 2.4e-126 420.2 0.3 2.9e-126 419.9 0.3 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EKE40177.1 - 1.2e-11 44.6 0.0 1.9e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 EKE40177.1 - 3.2e-11 43.2 0.1 4.6e-11 42.7 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 EKE40177.1 - 4.9e-07 29.3 0.2 1.2e-06 28.1 0.2 1.8 1 1 0 1 1 1 1 KaiC HHH_5 PF14520.6 EKE40177.1 - 6.4e-07 29.9 1.1 1.8e-06 28.4 1.1 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA_22 PF13401.6 EKE40177.1 - 0.00024 21.4 0.1 0.00052 20.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EKE40177.1 - 0.00067 19.1 0.2 0.019 14.3 0.2 2.2 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 EKE40177.1 - 0.016 15.0 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain GvpD PF07088.11 EKE40177.1 - 0.016 13.9 0.0 0.025 13.2 0.0 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein Histone_HNS PF00816.21 EKE40177.1 - 0.15 12.9 2.2 7.4 7.5 1.0 2.7 2 0 0 2 2 2 0 H-NS histone family ssDNA_TraI_N PF18272.1 EKE40177.1 - 0.18 11.8 0.8 0.4 10.7 0.8 1.5 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain PAXNEB PF05625.11 EKE40177.1 - 1.3 8.1 0.0 1.3 8.1 0.0 2.4 3 0 0 3 3 2 0 PAXNEB protein GWT1 PF06423.12 EKE40178.1 - 5.7e-16 59.0 4.4 5.7e-16 59.0 4.4 4.2 3 1 1 4 4 4 1 GWT1 KH_1 PF00013.29 EKE40179.1 - 3.6e-05 23.5 1.1 0.0001 22.0 0.6 1.9 2 0 0 2 2 2 1 KH domain KH_8 PF17903.1 EKE40179.1 - 6.8e-05 22.9 0.1 0.00019 21.4 0.0 1.7 2 0 0 2 2 2 1 Krr1 KH1 domain RNB PF00773.19 EKE40180.1 - 0.21 10.9 5.0 4.9 6.4 0.7 2.6 2 1 0 2 2 2 0 RNB domain DUF592 PF04574.13 EKE40181.1 - 0.027 14.2 3.9 0.03 14.1 0.9 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF592) CHASE6_C PF17150.4 EKE40181.1 - 0.13 13.0 2.4 3.7 8.3 0.1 3.8 3 1 0 3 3 3 0 C-terminal domain of two-partite extracellular sensor domain CLASP_N PF12348.8 EKE40181.1 - 0.13 11.8 11.4 2.2 7.8 4.6 3.1 1 1 0 2 2 2 0 CLASP N terminal V-ATPase_H_C PF11698.8 EKE40181.1 - 0.47 10.6 15.2 0.11 12.6 0.9 4.4 3 2 2 5 5 5 0 V-ATPase subunit H Lyase_aromatic PF00221.19 EKE40182.1 - 9.2e-18 64.1 0.0 2e-17 63.1 0.0 1.3 1 1 0 1 1 1 1 Aromatic amino acid lyase DUF5332 PF17266.2 EKE40183.1 - 0.18 11.5 3.2 0.079 12.6 0.9 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5332) SMK-1 PF04802.15 EKE40183.1 - 0.56 10.0 4.9 1.5 8.7 0.4 2.1 2 0 0 2 2 2 0 Component of IIS longevity pathway SMK-1 DUF2070 PF09843.9 EKE40184.1 - 0.012 13.9 8.4 0.015 13.7 8.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) EamA PF00892.20 EKE40184.1 - 0.067 13.4 8.9 0.047 13.9 2.1 2.2 1 1 2 3 3 3 0 EamA-like transporter family DUF5316 PF17247.2 EKE40184.1 - 0.38 10.8 0.0 0.38 10.8 0.0 2.8 4 0 0 4 4 4 0 Family of unknown function (DUF5316) PIG-F PF06699.11 EKE40184.1 - 0.41 10.8 4.3 0.55 10.4 3.8 1.6 1 1 0 1 1 1 0 GPI biosynthesis protein family Pig-F GtrA PF04138.14 EKE40184.1 - 0.73 10.1 10.3 0.06 13.6 1.4 2.8 2 2 1 3 3 3 0 GtrA-like protein DUF3021 PF11457.8 EKE40184.1 - 1.3 9.3 12.3 2.2 8.6 10.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3021) TssN PF17555.2 EKE40184.1 - 6.3 6.1 18.6 0.86 8.9 12.1 1.8 1 1 1 2 2 2 0 Type VI secretion system, TssN CTP_transf_like PF01467.26 EKE40185.1 - 3.4e-06 27.3 0.0 1.4e-05 25.3 0.0 1.9 1 1 0 1 1 1 1 Cytidylyltransferase-like SARA PF11409.8 EKE40185.1 - 0.12 12.5 1.8 5.3 7.3 0.1 2.4 2 0 0 2 2 2 0 Smad anchor for receptor activation (SARA) MgsA_C PF12002.8 EKE40186.1 - 4.2e-49 166.7 0.5 7.8e-49 165.8 0.0 1.7 2 0 0 2 2 1 1 MgsA AAA+ ATPase C terminal AAA PF00004.29 EKE40186.1 - 9.6e-17 61.6 0.1 2.5e-16 60.3 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EKE40186.1 - 1.6e-14 53.9 0.0 3.4e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 EKE40186.1 - 8.2e-13 48.5 0.5 3.7e-06 27.2 0.0 2.9 2 0 0 2 2 2 2 AAA C-terminal domain Sigma54_activat PF00158.26 EKE40186.1 - 3.8e-06 26.7 0.1 0.00013 21.7 0.1 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 EKE40186.1 - 1.2e-05 25.3 0.0 3e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EKE40186.1 - 2e-05 24.6 5.8 3.5e-05 23.8 0.0 2.9 2 1 0 3 3 3 1 AAA domain Sigma54_activ_2 PF14532.6 EKE40186.1 - 0.00048 20.3 0.0 0.001 19.2 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_22 PF13401.6 EKE40186.1 - 0.00085 19.6 1.4 0.041 14.2 0.3 2.5 1 1 1 2 2 2 1 AAA domain Rad17 PF03215.15 EKE40186.1 - 0.0011 18.9 0.3 0.0046 16.9 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 EKE40186.1 - 0.0022 18.4 0.2 0.057 13.8 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 EKE40186.1 - 0.0023 17.4 0.2 0.68 9.3 0.1 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EKE40186.1 - 0.0032 17.0 0.1 0.045 13.3 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region ATP-synt_ab PF00006.25 EKE40186.1 - 0.0036 17.0 0.0 0.008 15.9 0.0 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.22 EKE40186.1 - 0.0072 15.5 0.2 0.073 12.2 0.0 2.3 1 1 1 2 2 2 1 NB-ARC domain Viral_helicase1 PF01443.18 EKE40186.1 - 0.0074 16.1 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 EKE40186.1 - 0.017 15.7 0.2 0.099 13.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EKE40186.1 - 0.035 14.5 2.8 0.11 12.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 EKE40186.1 - 0.049 14.0 0.1 0.29 11.5 0.0 2.4 2 0 0 2 2 1 0 RNA helicase AAA_30 PF13604.6 EKE40186.1 - 0.092 12.5 0.1 1.3 8.7 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EKE40186.1 - 0.16 12.3 4.0 9 6.6 0.3 2.9 2 1 1 3 3 3 0 AAA domain AAA_25 PF13481.6 EKE40186.1 - 0.17 11.5 0.0 0.37 10.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EKE40186.1 - 0.17 12.4 0.0 0.17 12.4 0.0 2.7 2 1 0 2 2 1 0 ABC transporter AAA_11 PF13086.6 EKE40186.1 - 0.4 10.4 0.0 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain Steroid_dh PF02544.16 EKE40188.1 - 2.1e-29 102.5 6.7 2.1e-29 102.5 6.7 1.9 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF778 PF05608.12 EKE40190.1 - 2.8e-23 83.3 1.5 2.5e-11 44.3 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF778) DUF4796 PF16044.5 EKE40190.1 - 0.0026 17.4 0.3 0.0038 16.8 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4796) F_bP_aldolase PF01116.20 EKE40191.1 - 1.1e-97 326.9 0.0 1.3e-97 326.6 0.0 1.1 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II OST-HTH PF12872.7 EKE40191.1 - 0.012 15.4 0.0 0.028 14.2 0.0 1.6 1 0 0 1 1 1 0 OST-HTH/LOTUS domain Peptidase_M8 PF01457.16 EKE40192.1 - 1.1e-67 228.9 1.5 1.4e-67 228.6 1.5 1.1 1 0 0 1 1 1 1 Leishmanolysin TIG PF01833.24 EKE40192.1 - 0.014 15.4 0.1 0.059 13.5 0.1 2.2 1 0 0 1 1 1 0 IPT/TIG domain DUF21 PF01595.20 EKE40192.1 - 0.044 13.5 0.7 0.091 12.5 0.7 1.5 1 0 0 1 1 1 0 Cyclin M transmembrane N-terminal domain CSN8_PSD8_EIF3K PF10075.9 EKE40193.1 - 4.3e-16 59.2 1.6 5.1e-16 59.0 1.6 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EKE40193.1 - 0.00014 21.3 0.4 0.00018 21.0 0.4 1.1 1 0 0 1 1 1 1 SAC3/GANP family Bromodomain PF00439.25 EKE40194.1 - 5e-17 61.8 1.9 3e-16 59.3 0.8 2.7 2 0 0 2 2 2 1 Bromodomain DUF5377 PF17347.2 EKE40194.1 - 0.041 14.2 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5377) CBM_20 PF00686.19 EKE40195.1 - 0.00068 19.5 0.2 0.002 18.0 0.2 1.8 1 1 0 1 1 1 1 Starch binding domain START PF01852.19 EKE40196.1 - 5.6e-20 71.7 0.0 6.8e-20 71.4 0.0 1.0 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 EKE40196.1 - 0.00019 21.5 1.2 0.0018 18.3 1.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3074) Pkinase_Tyr PF07714.17 EKE40197.1 - 4.3e-32 111.4 0.0 5.8e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40197.1 - 1.5e-31 109.7 0.2 2.6e-31 109.0 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EKE40197.1 - 0.0028 17.0 0.0 0.005 16.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EKE40197.1 - 0.051 12.4 0.0 0.081 11.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PcfJ PF14284.6 EKE40197.1 - 0.096 12.6 0.4 0.26 11.2 0.1 1.8 2 0 0 2 2 2 0 PcfJ-like protein Poxvirus PF06227.12 EKE40197.1 - 1.3 8.8 9.1 0.82 9.4 2.1 2.9 3 0 0 3 3 3 0 dsDNA Poxvirus Rhodanese PF00581.20 EKE40198.1 - 1.3e-09 38.5 0.0 1.8e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain CitMHS PF03600.16 EKE40199.1 - 3.7e-35 121.6 20.7 9.6e-33 113.7 0.6 2.0 1 1 1 2 2 2 2 Citrate transporter TrkA_C PF02080.21 EKE40199.1 - 0.0018 18.1 0.0 0.0033 17.2 0.0 1.5 1 0 0 1 1 1 1 TrkA-C domain Tho2 PF11262.8 EKE40200.1 - 1.7e-27 96.4 10.5 3e-27 95.6 4.4 4.9 4 3 2 6 6 6 2 Transcription factor/nuclear export subunit protein 2 DUF3482 PF11981.8 EKE40200.1 - 0.93 8.8 5.3 2 7.8 5.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Slu7 PF11708.8 EKE40202.1 - 1.2 8.8 7.1 2.2 8.0 7.1 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor FRB_dom PF08771.11 EKE40202.1 - 1.2 9.5 7.2 0.42 11.1 0.1 4.3 5 0 0 5 5 5 0 FKBP12-rapamycin binding domain Patched PF02460.18 EKE40203.1 - 6.2e-76 256.1 30.2 6.2e-76 256.1 30.2 2.7 2 1 0 2 2 2 1 Patched family Sterol-sensing PF12349.8 EKE40203.1 - 2.1e-48 164.0 3.8 2.1e-48 164.0 3.8 2.9 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation NPC1_N PF16414.5 EKE40203.1 - 1.1e-18 67.7 9.6 2e-18 66.8 9.6 1.4 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus RB_B PF01857.20 EKE40204.1 - 0.0077 16.3 0.7 0.018 15.1 0.1 2.1 2 1 0 2 2 2 1 Retinoblastoma-associated protein B domain TFIIB PF00382.19 EKE40204.1 - 0.026 14.6 0.0 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EKE40204.1 - 0.11 12.1 0.1 0.21 11.1 0.1 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding DUF2120 PF09893.9 EKE40204.1 - 0.39 10.8 4.5 1.2 9.2 1.2 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) DUF2703 PF10865.8 EKE40204.1 - 0.58 10.3 4.1 1.1 9.5 0.3 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF2703) SET PF00856.28 EKE40205.1 - 9.8e-13 48.8 0.2 1.9e-12 47.9 0.2 1.5 1 0 0 1 1 1 1 SET domain SAF PF08666.12 EKE40205.1 - 0.023 15.3 0.0 11 6.8 0.0 2.3 2 0 0 2 2 2 0 SAF domain HMG_box_2 PF09011.10 EKE40206.1 - 0.0027 18.3 1.0 0.45 11.1 0.1 2.5 2 0 0 2 2 2 2 HMG-box domain DUF632 PF04782.12 EKE40206.1 - 0.01 15.2 1.4 0.012 14.9 0.3 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF632) START PF01852.19 EKE40207.1 - 1.4e-10 41.0 0.0 1.7e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 START domain DUF3074 PF11274.8 EKE40207.1 - 0.067 13.2 0.3 0.41 10.6 0.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) Peptidase_U49 PF10463.9 EKE40207.1 - 0.1 12.4 1.1 0.14 11.9 1.1 1.2 1 0 0 1 1 1 0 Peptidase U49 XRN_N PF03159.18 EKE40208.1 - 8.3e-62 208.8 7.6 5.4e-31 107.9 0.1 3.2 3 1 1 4 4 4 2 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EKE40208.1 - 2e-41 142.4 6.2 2.7e-31 109.0 1.0 2.9 3 0 0 3 3 3 2 Xrn1 helical domain BRO1 PF03097.18 EKE40208.1 - 0.025 13.4 0.0 0.039 12.8 0.0 1.2 1 0 0 1 1 1 0 BRO1-like domain Acetyltransf_1 PF00583.25 EKE40209.1 - 9.3e-12 45.2 0.1 1.1e-11 45.0 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EKE40209.1 - 5.1e-07 30.0 0.2 8.4e-07 29.3 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EKE40209.1 - 4e-06 26.8 0.0 5.1e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EKE40209.1 - 0.1 12.6 0.0 0.15 12.2 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA_30 PF13604.6 EKE40209.1 - 0.16 11.6 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain UPF0547 PF10571.9 EKE40210.1 - 1.7e-06 28.0 4.3 1.7e-06 28.0 4.3 2.1 2 0 0 2 2 2 1 Uncharacterised protein family UPF0547 zinc_ribbon_2 PF13240.6 EKE40210.1 - 9.5e-06 25.2 4.9 9.5e-06 25.2 4.9 2.2 2 0 0 2 2 2 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 EKE40210.1 - 3.1e-05 23.2 1.9 3.1e-05 23.2 1.9 2.2 2 0 0 2 2 2 1 zinc-ribbon domain DZR PF12773.7 EKE40210.1 - 6.4e-05 22.9 6.7 0.00019 21.3 6.7 1.8 1 1 0 1 1 1 1 Double zinc ribbon LIM PF00412.22 EKE40210.1 - 0.00045 20.4 1.0 0.00045 20.4 1.0 2.5 2 1 0 2 2 2 1 LIM domain zinc_ribbon_15 PF17032.5 EKE40210.1 - 0.0007 20.3 8.9 0.0023 18.6 8.9 1.8 1 1 0 1 1 1 1 zinc-ribbon family Cript PF10235.9 EKE40210.1 - 0.0016 19.0 8.6 0.0027 18.2 3.1 2.2 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT zf-RING-like PF08746.11 EKE40210.1 - 0.013 15.8 0.5 0.013 15.8 0.5 2.8 2 2 0 2 2 2 0 RING-like domain Cytochrom_c3_2 PF14537.6 EKE40210.1 - 0.021 15.3 2.3 0.025 15.0 2.3 1.1 1 0 0 1 1 1 0 Cytochrome c3 GHL6 PF14871.6 EKE40210.1 - 0.088 13.0 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 zf-RRN7 PF11781.8 EKE40210.1 - 0.12 12.0 7.7 0.32 10.7 4.6 2.5 2 1 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Zn-ribbon_8 PF09723.10 EKE40210.1 - 0.15 12.2 9.3 0.89 9.7 0.2 3.1 3 0 0 3 3 3 0 Zinc ribbon domain zf-ACC PF17848.1 EKE40210.1 - 0.82 9.8 9.6 7.2 6.8 0.1 3.3 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain zinc-ribbon_6 PF10005.9 EKE40210.1 - 1.1 10.0 7.1 7.1 7.4 0.3 2.3 2 1 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 EKE40210.1 - 1.7 8.3 9.8 0.46 10.0 5.5 2.2 2 1 0 2 2 2 0 TFIIB zinc-binding IBR PF01485.21 EKE40210.1 - 1.8 8.8 10.6 0.5 10.6 6.5 2.3 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain YhfH PF14149.6 EKE40210.1 - 2.2 8.3 9.3 41 4.3 1.9 3.2 2 1 1 3 3 3 0 YhfH-like protein C1_1 PF00130.22 EKE40210.1 - 2.3 8.2 9.3 10 6.1 0.8 3.0 2 2 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ribosomal_L32p PF01783.23 EKE40210.1 - 3 8.2 6.3 4.7 7.6 0.4 2.5 3 0 0 3 3 2 0 Ribosomal L32p protein family DUF2175 PF09943.9 EKE40210.1 - 7.4 6.9 10.8 0.62 10.4 2.0 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) RasGEF PF00617.19 EKE40211.1 - 0.00048 20.4 0.1 0.0017 18.6 0.1 2.0 1 0 0 1 1 1 1 RasGEF domain PA26 PF04636.13 EKE40211.1 - 0.03 13.3 5.7 0.054 12.4 5.7 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) COMPASS-Shg1 PF05205.12 EKE40211.1 - 0.25 12.1 6.2 0.47 11.2 4.4 2.5 2 1 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 Goodbye PF17109.5 EKE40211.1 - 0.39 11.2 4.2 7.5 7.0 2.2 3.0 2 1 0 2 2 2 0 fungal STAND N-terminal Goodbye domain HHH_6 PF14579.6 EKE40212.1 - 0.16 12.3 1.7 2.5 8.4 0.3 2.5 1 1 0 2 2 2 0 Helix-hairpin-helix motif TfuA PF07812.12 EKE40212.1 - 1.9 8.2 6.6 1.5 8.5 0.0 2.8 2 1 0 3 3 3 0 TfuA-like protein NUFIP1 PF10453.9 EKE40213.1 - 1.8e-05 24.5 21.3 1.8e-05 24.5 21.3 3.7 1 1 1 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) DUF5355 PF17306.2 EKE40213.1 - 0.001 18.2 5.9 0.001 18.2 5.9 1.9 1 1 1 2 2 2 1 Family of unknown function (DUF5355) PEX11 PF05648.14 EKE40213.1 - 0.033 13.6 1.4 0.033 13.6 1.4 1.9 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Sec62 PF03839.16 EKE40213.1 - 2.5 7.5 21.4 3.4 7.1 21.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Borrelia_P83 PF05262.11 EKE40213.1 - 3.8 5.9 22.4 4 5.8 22.4 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein CLN3 PF02487.17 EKE40213.1 - 4.1 6.3 5.2 4.6 6.2 5.2 1.2 1 0 0 1 1 1 0 CLN3 protein Rotamase_2 PF13145.6 EKE40213.1 - 8.2 7.3 17.1 1.7e+02 3.0 17.1 2.1 1 1 0 1 1 1 0 PPIC-type PPIASE domain GAGA_bind PF06217.12 EKE40213.1 - 9.1 6.5 16.5 11 6.2 16.5 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family CDC27 PF09507.10 EKE40213.1 - 9.4 5.5 31.6 11 5.3 31.6 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 YaaC PF14175.6 EKE40217.1 - 0.018 14.3 0.3 0.027 13.7 0.3 1.2 1 0 0 1 1 1 0 YaaC-like Protein C1_2 PF03107.16 EKE40218.1 - 1.7e-10 41.0 50.6 2.1e-07 31.2 9.7 3.2 3 0 0 3 3 3 3 C1 domain zf-B_box PF00643.24 EKE40218.1 - 8.1e-05 22.7 44.3 0.004 17.3 10.1 3.6 3 0 0 3 3 3 3 B-box zinc finger zf-UBR PF02207.20 EKE40218.1 - 0.0063 16.6 41.8 0.031 14.4 19.4 3.5 2 1 1 3 3 3 2 Putative zinc finger in N-recognin (UBR box) IBR PF01485.21 EKE40218.1 - 0.029 14.6 5.2 0.029 14.6 5.2 3.4 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain C1_1 PF00130.22 EKE40218.1 - 0.68 9.9 49.2 0.47 10.4 11.0 4.3 3 2 1 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE PF01363.21 EKE40218.1 - 2.4 8.3 38.8 0.19 11.9 6.1 3.3 2 1 1 3 3 3 0 FYVE zinc finger IF-2B PF01008.17 EKE40220.1 - 2.7e-46 158.0 0.9 2.5e-45 154.9 0.9 2.0 1 1 0 1 1 1 1 Initiation factor 2 subunit family SpoU_sub_bind PF08032.12 EKE40220.1 - 0.018 15.3 0.1 0.05 13.9 0.1 1.8 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding MIP-T3_C PF17749.1 EKE40220.1 - 0.23 11.4 1.5 0.28 11.1 0.4 1.6 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region La PF05383.17 EKE40222.1 - 7.6e-16 57.9 2.1 1.2e-15 57.3 0.1 2.4 3 0 0 3 3 3 1 La domain RRM_1 PF00076.22 EKE40222.1 - 5.9e-07 29.2 4.3 6.3e-05 22.7 0.4 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Neur_chan_memb PF02932.16 EKE40222.1 - 0.18 11.9 7.2 0.32 11.0 7.2 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 EKE40222.1 - 0.35 9.7 13.3 0.6 8.9 13.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter AXH PF08517.12 EKE40222.1 - 3.5 8.2 6.2 2 9.0 3.5 2.1 2 0 0 2 2 2 0 Ataxin-1 and HBP1 module (AXH) DUF5338 PF17273.2 EKE40222.1 - 8.7 6.5 9.9 0.83 9.8 1.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5338) Thioredoxin PF00085.20 EKE40223.1 - 2.1e-25 88.7 0.1 2.4e-25 88.5 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EKE40223.1 - 0.0028 17.9 0.1 0.0037 17.6 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like IBD PF10416.9 EKE40223.1 - 0.012 15.6 0.1 0.024 14.6 0.1 1.5 2 0 0 2 2 2 0 Transcription-initiator DNA-binding domain IBD Phosducin PF02114.16 EKE40223.1 - 0.017 14.1 0.0 0.017 14.1 0.0 1.1 1 0 0 1 1 1 0 Phosducin Thioredoxin_9 PF14595.6 EKE40223.1 - 0.029 14.1 0.1 0.031 14.0 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_2 PF13098.6 EKE40223.1 - 0.11 12.9 0.2 1 9.8 0.2 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain MKLP1_Arf_bdg PF16540.5 EKE40224.1 - 8.6 6.5 17.1 0.11 12.5 0.4 4.0 4 0 0 4 4 4 0 Arf6-interacting domain of mitotic kinesin-like protein 1 ASF1_hist_chap PF04729.13 EKE40226.1 - 9.3e-47 158.8 0.3 1.4e-46 158.3 0.0 1.4 2 0 0 2 2 2 1 ASF1 like histone chaperone DNA_pol_phi PF04931.13 EKE40226.1 - 2.1 6.3 8.1 2.6 6.0 8.1 1.0 1 0 0 1 1 1 0 DNA polymerase phi GTP_EFTU PF00009.27 EKE40228.1 - 1.5e-32 112.7 0.0 1.5e-32 112.7 0.0 3.7 4 2 0 4 4 4 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EKE40228.1 - 4.8e-19 68.4 0.6 4.8e-19 68.4 0.6 2.3 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EKE40228.1 - 1.6e-12 47.6 2.8 3.7e-09 36.9 0.2 3.8 2 0 0 2 2 2 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EKE40228.1 - 1.9e-12 46.9 0.0 8.9e-12 44.8 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EKE40228.1 - 1.8e-05 24.8 0.1 1.8e-05 24.8 0.1 3.9 3 1 1 5 5 5 1 50S ribosome-binding GTPase Roc PF08477.13 EKE40228.1 - 0.00013 22.1 0.0 0.0005 20.3 0.0 2.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EKE40228.1 - 0.012 15.4 0.1 0.012 15.4 0.1 3.6 2 1 2 5 5 5 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EKE40228.1 - 3.2 8.0 5.7 1.4 9.2 0.1 3.1 2 1 0 2 2 2 0 AAA domain Ribosomal_L22 PF00237.19 EKE40229.1 - 2.6e-33 114.3 0.2 3.5e-33 113.9 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e ProQ PF04352.13 EKE40230.1 - 0.066 13.1 0.1 0.09 12.7 0.1 1.2 1 0 0 1 1 1 0 ProQ/FINO family RRM_1 PF00076.22 EKE40231.1 - 2.8e-14 52.7 0.1 4.7e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKE40231.1 - 0.0035 16.9 0.0 0.0076 15.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKE40231.1 - 0.037 13.9 0.0 0.083 12.8 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif IncFII_repA PF02387.15 EKE40234.1 - 0.02 14.2 0.1 0.022 14.0 0.1 1.1 1 0 0 1 1 1 0 IncFII RepA protein family DUF4860 PF16152.5 EKE40235.1 - 0.32 10.9 1.7 24 4.9 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4860) Erf4 PF10256.9 EKE40236.1 - 0.0018 18.4 0.1 0.002 18.2 0.1 1.3 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Ribosomal_L34e PF01199.18 EKE40237.1 - 5.1e-36 122.9 5.3 5.1e-36 122.9 5.3 1.9 2 0 0 2 2 2 1 Ribosomal protein L34e DUF1062 PF06353.12 EKE40237.1 - 0.039 14.8 0.8 0.039 14.8 0.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1062) zinc_ribbon_12 PF11331.8 EKE40237.1 - 0.29 11.0 3.5 1.1 9.1 0.8 2.5 2 0 0 2 2 2 0 Probable zinc-ribbon domain Ribosomal_S14 PF00253.21 EKE40238.1 - 3.6e-14 52.2 4.0 4.1e-14 52.1 4.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DZR PF12773.7 EKE40238.1 - 0.019 14.9 0.2 0.023 14.7 0.2 1.2 1 0 0 1 1 1 0 Double zinc ribbon SNARE_assoc PF09335.11 EKE40239.1 - 1.5e-20 73.9 7.5 1.5e-20 73.9 7.5 1.9 2 0 0 2 2 2 1 SNARE associated Golgi protein Med21 PF11221.8 EKE40240.1 - 0.19 12.0 13.1 1.9 8.8 3.6 3.2 3 0 0 3 3 3 0 Subunit 21 of Mediator complex Mod_r PF07200.13 EKE40240.1 - 0.6 10.2 11.3 0.15 12.2 7.4 2.0 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DMPK_coil PF08826.10 EKE40240.1 - 5.1 7.3 10.5 0.54 10.4 4.7 2.3 2 1 0 2 2 2 0 DMPK coiled coil domain like FlaC_arch PF05377.11 EKE40240.1 - 6.9 7.2 7.8 21 5.6 0.5 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Rad9 PF04139.13 EKE40241.1 - 3.8e-14 52.8 4.9 4.5e-14 52.5 4.9 1.1 1 0 0 1 1 1 1 Rad9 RSS_P20 PF11757.8 EKE40241.1 - 0.018 15.5 1.4 5 7.6 0.0 2.7 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain Tubulin PF00091.25 EKE40242.1 - 1.9e-68 230.6 0.3 5.2e-68 229.1 0.1 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EKE40242.1 - 1.2e-35 122.4 0.0 1.8e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EKE40242.1 - 7.5e-06 26.2 0.0 1.5e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EKE40242.1 - 0.037 13.7 0.0 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 Tubulin domain Tubulin_2 PF13809.6 EKE40242.1 - 0.11 11.7 0.1 0.29 10.3 0.0 1.7 2 0 0 2 2 2 0 Tubulin like DUF3507 PF12015.8 EKE40242.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) Ank_2 PF12796.7 EKE40243.1 - 4.1e-18 65.8 0.1 1.1e-07 32.3 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE40243.1 - 2.7e-13 50.1 0.1 3.8e-06 27.3 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE40243.1 - 2.9e-13 49.8 0.2 5.2e-05 23.5 0.4 2.8 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE40243.1 - 2.9e-12 45.6 2.3 0.0093 16.4 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Patatin PF01734.22 EKE40243.1 - 2.4e-10 40.9 0.0 1.1e-09 38.8 0.0 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase Ank PF00023.30 EKE40243.1 - 3.4e-10 39.9 1.7 0.056 13.9 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat RhoGEF PF00621.20 EKE40244.1 - 7.8e-11 42.5 5.4 7.8e-11 42.5 5.4 3.3 3 1 1 4 4 4 1 RhoGEF domain 4HPAD_g_N PF18671.1 EKE40245.1 - 0.0034 17.1 1.0 0.0087 15.8 1.0 1.7 1 0 0 1 1 1 1 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal CTU2 PF10288.9 EKE40245.1 - 0.0047 17.2 0.4 0.0047 17.2 0.4 2.1 2 0 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 zf-RING_10 PF16685.5 EKE40245.1 - 6.3 7.0 14.5 0.35 11.0 1.6 3.1 3 1 0 3 3 3 0 zinc RING finger of MSL2 Exonuc_VII_L PF02601.15 EKE40246.1 - 0.018 14.6 2.2 0.025 14.1 2.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Osmo_CC PF08946.10 EKE40246.1 - 0.3 11.4 3.9 0.21 11.9 0.7 2.6 2 1 0 2 2 2 0 Osmosensory transporter coiled coil PSI_integrin PF17205.3 EKE40247.1 - 1.6 8.6 11.0 25 4.7 11.0 2.5 1 1 0 1 1 1 0 Integrin plexin domain Sec23_trunk PF04811.15 EKE40250.1 - 4.3e-24 85.4 0.5 9.5e-24 84.3 0.5 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EKE40250.1 - 3.4e-12 46.9 0.3 3.4e-11 43.7 0.1 2.5 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EKE40250.1 - 0.01 15.8 2.8 0.01 15.8 2.8 2.0 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 EKE40250.1 - 0.037 13.9 2.8 0.064 13.1 1.4 2.1 2 1 0 2 2 2 0 Sec23/Sec24 helical domain Thioredoxin PF00085.20 EKE40252.1 - 7.7e-28 96.5 0.1 8.6e-28 96.4 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EKE40252.1 - 3.1e-08 33.8 0.2 2e-07 31.2 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EKE40252.1 - 1.5e-06 28.0 0.0 1.5e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 EKE40252.1 - 2.6e-06 27.2 0.1 0.00012 21.8 0.0 2.0 1 1 1 2 2 2 1 Redoxin AhpC-TSA PF00578.21 EKE40252.1 - 3.2e-05 23.9 0.1 4.4e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 EKE40252.1 - 3.4e-05 24.3 0.1 0.00014 22.3 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EKE40252.1 - 0.00023 20.6 0.0 0.00023 20.6 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EKE40252.1 - 0.012 15.7 0.1 0.028 14.6 0.1 1.5 1 1 0 1 1 1 0 Thioredoxin-like TraF PF13728.6 EKE40252.1 - 0.06 13.2 0.0 0.082 12.7 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Glutaredoxin PF00462.24 EKE40252.1 - 0.098 12.9 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 Glutaredoxin bZIP_Maf PF03131.17 EKE40253.1 - 1.9e-05 25.1 6.9 2.7e-05 24.6 6.9 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EKE40253.1 - 0.00065 19.7 8.8 0.00065 19.7 8.8 1.8 1 1 1 2 2 2 1 bZIP transcription factor Alpha-2-MRAP_C PF06401.11 EKE40253.1 - 0.0075 16.3 8.8 0.0095 15.9 8.8 1.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin RAP, C-terminal domain bZIP_2 PF07716.15 EKE40253.1 - 0.012 15.7 7.3 0.012 15.7 7.3 2.1 1 1 0 2 2 2 0 Basic region leucine zipper Nefa_Nip30_N PF10187.9 EKE40253.1 - 0.14 12.5 8.1 0.043 14.2 4.9 1.7 1 1 0 1 1 1 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF3987 PF13148.6 EKE40253.1 - 0.17 10.8 2.0 0.2 10.6 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) SOGA PF11365.8 EKE40253.1 - 0.19 12.8 8.8 0.81 10.8 1.4 2.2 1 1 1 2 2 2 0 Protein SOGA Tox-ODYAM1 PF15642.6 EKE40253.1 - 0.26 10.2 7.9 0.29 10.1 7.9 1.0 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus CHD5 PF04420.14 EKE40253.1 - 0.5 10.2 0.1 0.5 10.2 0.1 2.0 2 1 0 2 2 2 0 CHD5-like protein AAA_23 PF13476.6 EKE40253.1 - 0.9 10.0 14.0 1.1 9.7 14.0 1.1 1 0 0 1 1 1 0 AAA domain DUF724 PF05266.14 EKE40253.1 - 0.96 9.2 11.2 1.2 8.9 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TMPIT PF07851.13 EKE40253.1 - 1.9 7.7 8.7 2.6 7.2 8.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein Pkinase PF00069.25 EKE40254.1 - 4.9e-64 216.2 0.9 5.9e-63 212.7 0.9 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40254.1 - 2.4e-32 112.3 0.2 2.7e-31 108.8 0.2 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE40254.1 - 1.1e-08 34.7 0.1 2.4e-06 27.1 0.0 2.9 1 1 0 2 2 2 1 Kinase-like FHA PF00498.26 EKE40254.1 - 3.3e-06 27.3 0.4 7.5e-06 26.2 0.4 1.6 1 0 0 1 1 1 1 FHA domain PIP49_C PF12260.8 EKE40254.1 - 0.011 15.4 0.0 0.026 14.2 0.0 1.6 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 APH PF01636.23 EKE40254.1 - 0.051 13.5 0.0 0.22 11.4 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EKE40254.1 - 0.053 12.3 0.0 0.12 11.1 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Kdo PF06293.14 EKE40254.1 - 0.099 12.0 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EKE40254.1 - 0.1 12.1 7.3 0.5 9.9 0.1 2.7 2 1 0 3 3 3 0 PhoP regulatory network protein YrbL tRNA-synt_1g PF09334.11 EKE40255.1 - 1.6e-147 491.3 1.6 2.1e-147 491.0 1.6 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EKE40255.1 - 3.7e-12 45.3 2.4 2.7e-05 22.6 0.1 3.3 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EKE40255.1 - 0.00063 19.2 2.0 0.0064 15.9 0.0 3.0 3 1 1 4 4 4 1 tRNA synthetases class I (C) catalytic domain FliG_C PF01706.16 EKE40255.1 - 0.023 14.9 0.2 0.73 10.1 0.1 2.4 2 0 0 2 2 2 0 FliG C-terminal domain DUF2540 PF10802.8 EKE40255.1 - 0.12 12.5 1.0 0.27 11.3 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) Laminin_EGF PF00053.24 EKE40255.1 - 0.16 12.1 7.7 0.64 10.2 7.7 2.1 1 0 0 1 1 1 0 Laminin EGF domain zinc-ribbons_6 PF07191.12 EKE40255.1 - 0.61 10.1 8.0 4.6 7.3 8.0 2.4 1 1 0 1 1 1 0 zinc-ribbons C1_1 PF00130.22 EKE40255.1 - 1 9.3 7.6 0.87 9.5 0.8 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-CHY PF05495.12 EKE40255.1 - 1.4 9.4 6.5 7.1 7.2 6.5 2.3 1 1 0 1 1 1 0 CHY zinc finger PI_PP_I PF18363.1 EKE40256.1 - 0.00033 20.8 11.5 0.042 14.0 2.4 2.2 1 1 1 2 2 2 2 Phosphoinositide phosphatase insertion domain MAP65_ASE1 PF03999.12 EKE40256.1 - 0.0059 15.4 19.5 0.0079 14.9 19.5 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Filament PF00038.21 EKE40256.1 - 0.027 14.1 20.7 0.027 14.1 18.7 1.8 1 1 0 1 1 1 0 Intermediate filament protein GAS PF13851.6 EKE40256.1 - 0.029 13.7 27.4 0.032 13.6 15.7 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4472 PF14739.6 EKE40256.1 - 0.042 14.6 23.2 0.14 12.9 10.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4472) DUF3584 PF12128.8 EKE40256.1 - 0.3 8.6 20.6 0.37 8.3 20.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 EKE40256.1 - 0.38 9.6 22.7 0.87 8.4 22.6 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein XLF PF09302.11 EKE40256.1 - 0.41 10.8 12.4 0.49 10.5 12.4 1.2 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component HAUS-augmin3 PF14932.6 EKE40256.1 - 0.51 9.9 20.0 0.8 9.2 18.7 1.8 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 SKA2 PF16740.5 EKE40256.1 - 0.56 10.0 17.8 2.2 8.1 12.6 3.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Cep57_MT_bd PF06657.13 EKE40256.1 - 0.78 10.2 14.0 0.14 12.7 5.8 2.8 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Rotamase PF00639.21 EKE40256.1 - 1.1 10.3 8.3 6.7 7.8 1.2 2.5 1 1 1 2 2 2 0 PPIC-type PPIASE domain Syntaxin-6_N PF09177.11 EKE40256.1 - 1.2 9.7 10.8 1.6 9.3 7.1 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF4407 PF14362.6 EKE40256.1 - 1.4 8.2 18.8 9.8 5.4 18.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2203 PF09969.9 EKE40256.1 - 1.6 9.5 11.0 5.7 7.7 4.7 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Exonuc_VII_L PF02601.15 EKE40256.1 - 1.7 8.1 14.5 2.4 7.6 14.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6_N PF17675.1 EKE40256.1 - 1.9 9.0 25.5 4.1 7.9 15.4 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region BLOC1_2 PF10046.9 EKE40256.1 - 2 8.8 23.7 0.12 12.6 8.4 2.7 2 1 1 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CALCOCO1 PF07888.11 EKE40256.1 - 2.4 6.9 20.1 8.1 5.2 20.1 1.7 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like PRKG1_interact PF15898.5 EKE40256.1 - 2.4 9.1 19.9 0.44 11.5 12.1 2.5 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain TPD52 PF04201.15 EKE40256.1 - 4.3 6.9 15.4 12 5.4 11.0 2.9 1 1 1 2 2 2 0 Tumour protein D52 family LMBR1 PF04791.16 EKE40256.1 - 4.5 6.1 14.1 5.1 5.9 14.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Nup88 PF10168.9 EKE40256.1 - 6.5 4.4 22.8 7.5 4.2 22.8 1.0 1 0 0 1 1 1 0 Nuclear pore component ADIP PF11559.8 EKE40256.1 - 8 6.5 27.8 0.57 10.3 15.3 2.7 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding THOC7 PF05615.13 EKE40256.1 - 8.4 6.7 21.3 0.7 10.2 5.5 2.8 1 1 1 2 2 2 0 Tho complex subunit 7 Osmo_CC PF08946.10 EKE40256.1 - 9.2 6.6 13.8 4.8 7.5 3.8 3.4 2 1 1 3 3 3 0 Osmosensory transporter coiled coil PP2C_2 PF13672.6 EKE40257.1 - 0.00036 20.2 0.0 0.00051 19.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C DnaJ_C PF01556.18 EKE40259.1 - 2.9e-36 124.8 0.9 4e-36 124.3 0.9 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EKE40259.1 - 7.6e-28 96.4 3.8 8e-28 96.4 1.7 2.2 2 0 0 2 2 2 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EKE40259.1 - 1.3e-12 47.9 19.4 2.3e-12 47.1 19.4 1.5 1 0 0 1 1 1 1 DnaJ central domain FYVE_2 PF02318.16 EKE40259.1 - 0.37 11.0 10.1 1.3 9.2 9.9 1.8 1 1 1 2 2 2 0 FYVE-type zinc finger Anti-TRAP PF15777.5 EKE40259.1 - 3.2 7.8 15.4 1.3 9.1 0.3 3.1 1 1 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Cytochrome_C7 PF14522.6 EKE40259.1 - 3.3 7.8 8.0 14 5.7 1.7 2.5 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c zf-RING_10 PF16685.5 EKE40259.1 - 5.9 7.1 8.1 8.5 6.6 1.3 2.5 2 0 0 2 2 2 0 zinc RING finger of MSL2 DZR PF12773.7 EKE40259.1 - 6.2 6.9 9.9 23 5.1 10.2 1.8 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 EKE40259.1 - 6.5 6.8 10.6 2.6 8.1 1.6 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Mitochondr_Som1 PF11093.8 EKE40260.1 - 0.00049 20.0 3.1 0.0016 18.4 3.1 2.0 1 0 0 1 1 1 1 Mitochondrial export protein Som1 DUF4119 PF13494.6 EKE40260.1 - 0.0078 16.3 0.7 0.026 14.6 0.7 1.9 1 0 0 1 1 1 1 Domain of unknown function, B. Theta Gene description (DUF4119) Rap_GAP PF02145.15 EKE40261.1 - 4.2e-10 39.5 2.1 1.8e-09 37.4 2.1 2.1 1 1 0 1 1 1 1 Rap/ran-GAP POTRA_2 PF08479.11 EKE40261.1 - 0.068 13.0 0.1 0.42 10.5 0.0 2.5 2 0 0 2 2 2 0 POTRA domain, ShlB-type Suf PF05843.14 EKE40262.1 - 2.9e-13 50.5 2.3 7e-11 42.6 0.6 2.1 1 1 0 2 2 2 2 Suppressor of forked protein (Suf) GCR1_C PF12550.8 EKE40262.1 - 0.081 13.2 1.1 0.77 10.1 0.2 2.3 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes Myb_DNA-bind_4 PF13837.6 EKE40263.1 - 0.024 15.0 0.6 0.04 14.3 0.3 1.6 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain TetR_C_4 PF08359.11 EKE40263.1 - 0.065 13.4 0.1 0.63 10.2 0.0 2.2 2 0 0 2 2 2 0 YsiA-like protein, C-terminal region Wzy_C PF04932.15 EKE40264.1 - 0.023 14.3 7.2 0.068 12.8 1.8 2.0 2 0 0 2 2 2 0 O-Antigen ligase Cytochrom_B_C PF00032.17 EKE40264.1 - 0.1 12.9 4.1 0.062 13.6 2.5 1.5 1 1 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD Tetraspanin PF00335.20 EKE40264.1 - 0.3 10.8 9.6 0.33 10.6 9.6 1.1 1 0 0 1 1 1 0 Tetraspanin family SieB PF14163.6 EKE40264.1 - 0.35 10.3 8.5 0.077 12.5 2.3 2.3 2 0 0 2 2 2 0 Super-infection exclusion protein B VirB3 PF05101.13 EKE40264.1 - 0.52 10.6 6.1 0.3 11.3 0.3 2.2 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein DUF4131 PF13567.6 EKE40264.1 - 0.67 9.6 7.8 0.084 12.5 2.3 1.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4131) DHO_dh PF01180.21 EKE40265.1 - 2.2e-28 99.4 0.1 5e-28 98.2 0.1 1.6 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase Fer4_20 PF14691.6 EKE40265.1 - 3e-24 85.0 12.8 2.3e-23 82.1 7.7 3.1 3 0 0 3 3 2 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_21 PF14697.6 EKE40265.1 - 2.5e-16 59.5 10.7 2.5e-16 59.5 10.7 3.1 2 1 0 2 2 1 1 4Fe-4S dicluster domain Pyr_redox_2 PF07992.14 EKE40265.1 - 1.5e-15 57.3 0.1 2.9e-15 56.3 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4 PF00037.27 EKE40265.1 - 2e-09 36.9 19.0 5.2e-08 32.4 3.7 3.3 3 0 0 3 3 2 2 4Fe-4S binding domain Pyr_redox_3 PF13738.6 EKE40265.1 - 6.4e-08 32.2 0.0 0.0004 19.7 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EKE40265.1 - 2.9e-07 30.9 0.2 0.015 15.8 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_7 PF12838.7 EKE40265.1 - 3.4e-07 30.8 10.3 3.4e-07 30.8 10.3 3.1 3 0 0 3 3 2 2 4Fe-4S dicluster domain NAD_binding_8 PF13450.6 EKE40265.1 - 2.3e-06 27.8 0.0 9.2e-06 25.8 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Fer4_6 PF12837.7 EKE40265.1 - 4.4e-06 26.5 26.1 6.2e-05 22.9 4.0 4.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_9 PF13187.6 EKE40265.1 - 1.5e-05 25.0 9.4 1.5e-05 25.0 9.4 3.4 2 2 1 3 3 2 1 4Fe-4S dicluster domain Thi4 PF01946.17 EKE40265.1 - 5.9e-05 22.4 0.0 0.00018 20.8 0.0 1.8 1 0 0 1 1 1 1 Thi4 family Shikimate_DH PF01488.20 EKE40265.1 - 9.5e-05 22.5 4.2 0.018 15.1 0.0 3.4 4 0 0 4 4 3 1 Shikimate / quinate 5-dehydrogenase Fer4_10 PF13237.6 EKE40265.1 - 0.00012 22.1 22.7 0.00028 20.9 1.5 3.8 2 1 2 4 4 4 2 4Fe-4S dicluster domain NAD_binding_7 PF13241.6 EKE40265.1 - 0.0012 19.3 0.3 0.47 10.9 0.1 2.9 2 0 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_2 PF00890.24 EKE40265.1 - 0.0017 17.5 0.2 0.0068 15.5 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain Fer4_2 PF12797.7 EKE40265.1 - 0.0018 18.3 2.8 0.0018 18.3 2.8 4.0 3 0 0 3 3 2 2 4Fe-4S binding domain AlaDh_PNT_C PF01262.21 EKE40265.1 - 0.0022 17.3 1.0 0.051 12.9 0.0 2.6 2 1 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.21 EKE40265.1 - 0.0044 16.8 0.0 0.097 12.4 0.0 2.4 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 EKE40265.1 - 0.0054 16.1 0.1 1.5 8.2 0.0 2.4 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Fer4_15 PF13459.6 EKE40265.1 - 0.0062 17.3 5.1 0.3 11.8 0.3 2.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_16 PF13484.6 EKE40265.1 - 0.0084 17.0 23.0 0.015 16.2 1.9 3.9 2 1 2 4 4 4 1 4Fe-4S double cluster binding domain FlpD PF02662.16 EKE40265.1 - 0.014 15.4 3.8 0.13 12.2 0.2 3.1 2 1 1 3 3 2 0 Methyl-viologen-reducing hydrogenase, delta subunit HI0933_like PF03486.14 EKE40265.1 - 0.015 14.1 0.1 0.024 13.3 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein FAD_oxidored PF12831.7 EKE40265.1 - 0.02 14.2 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EKE40265.1 - 0.022 14.0 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain F420_oxidored PF03807.17 EKE40265.1 - 0.023 15.3 2.1 11 6.7 0.0 3.5 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent DAO PF01266.24 EKE40265.1 - 0.045 13.3 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase ThiF PF00899.21 EKE40265.1 - 0.065 12.6 0.0 7.7 5.8 0.0 2.5 2 0 0 2 2 2 0 ThiF family NAD_binding_9 PF13454.6 EKE40265.1 - 0.069 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding GIDA PF01134.22 EKE40265.1 - 0.1 11.6 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A XdhC_C PF13478.6 EKE40265.1 - 0.12 12.8 0.0 12 6.4 0.0 2.7 2 0 0 2 2 2 0 XdhC Rossmann domain Fer4_22 PF17179.4 EKE40265.1 - 0.78 10.6 16.5 1.7 9.6 0.8 4.3 4 0 0 4 4 3 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 EKE40265.1 - 4.7 7.8 26.7 0.21 12.1 0.2 3.9 3 1 1 4 4 3 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 EKE40265.1 - 7 7.2 34.4 0.31 11.5 2.6 3.8 2 1 2 4 4 3 0 4Fe-4S dicluster domain Ku PF02735.16 EKE40266.1 - 8e-13 48.6 0.0 1.4e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain DUF4518 PF15008.6 EKE40266.1 - 0.062 12.5 2.5 0.06 12.5 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) PP2C PF00481.21 EKE40268.1 - 1.6e-27 96.8 0.0 2.5e-27 96.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE40268.1 - 1.1e-05 25.2 0.0 2.4e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C Peptidase_M42 PF05343.14 EKE40268.1 - 0.037 13.0 0.5 0.4 9.7 0.1 1.9 1 1 1 2 2 2 0 M42 glutamyl aminopeptidase EMC3_TMCO1 PF01956.16 EKE40269.1 - 1.1e-32 113.1 1.2 1.8e-32 112.4 1.2 1.3 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Myosin_TH1 PF06017.13 EKE40269.1 - 0.021 14.5 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding Cnd1 PF12717.7 EKE40270.1 - 0.13 12.3 5.7 0.76 9.8 1.2 2.9 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF2852 PF11014.8 EKE40270.1 - 0.2 11.8 0.7 0.42 10.8 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) CUTL PF16557.5 EKE40270.1 - 1.7 8.9 8.4 17 5.7 0.1 4.5 4 0 0 4 4 4 0 CUT1-like DNA-binding domain of SATB IBB PF01749.20 EKE40270.1 - 2.3 8.7 5.5 2.2 8.8 3.3 2.1 2 1 0 2 2 2 0 Importin beta binding domain His_kinase PF06580.13 EKE40270.1 - 3.9 7.9 6.4 2.1 8.8 0.2 3.6 4 1 0 4 4 4 0 Histidine kinase TFCD_C PF12612.8 EKE40270.1 - 6.4 6.6 7.7 6.8 6.5 0.1 3.8 4 1 1 5 5 5 0 Tubulin folding cofactor D C terminal Maelstrom PF13017.6 EKE40271.1 - 1.6e-18 67.2 0.2 2.2e-18 66.7 0.2 1.1 1 0 0 1 1 1 1 piRNA pathway germ-plasm component BRO1 PF03097.18 EKE40272.1 - 1.4e-06 27.4 0.4 1.4e-06 27.4 0.4 1.8 2 0 0 2 2 2 1 BRO1-like domain TPR_12 PF13424.6 EKE40272.1 - 0.00012 22.3 0.0 0.00031 21.0 0.0 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EKE40272.1 - 0.0026 17.5 0.0 0.012 15.4 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EKE40272.1 - 0.02 14.9 0.0 0.072 13.1 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EKE40272.1 - 0.049 13.9 0.0 0.16 12.2 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EKE40272.1 - 0.11 12.7 0.0 0.48 10.7 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Med9 PF07544.13 EKE40272.1 - 3.4 7.8 12.0 0.13 12.3 0.4 3.5 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Actin PF00022.19 EKE40273.1 - 1.3e-45 155.8 0.0 2e-22 79.4 0.0 2.1 1 1 1 2 2 2 2 Actin Telomere_reg-2 PF10193.9 EKE40274.1 - 6.7e-08 32.9 0.1 3.1e-06 27.6 0.0 3.1 2 1 0 2 2 2 1 Telomere length regulation protein Med12-LCEWAV PF12145.8 EKE40274.1 - 4 6.2 9.1 0.081 11.8 0.3 2.3 3 0 0 3 3 3 0 Eukaryotic Mediator 12 subunit domain Yippee-Mis18 PF03226.14 EKE40275.1 - 1.2e-06 28.6 3.1 1.2e-06 28.6 3.1 2.2 1 1 1 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly LON_substr_bdg PF02190.16 EKE40275.1 - 8.7e-05 22.5 0.8 0.00017 21.5 0.7 1.6 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain DHR-2 PF06920.13 EKE40276.1 - 1.3e-44 152.7 10.9 1.3e-44 152.7 10.9 2.8 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 EKE40276.1 - 9.7e-14 51.6 4.8 3.1e-13 50.0 0.8 2.9 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins STPPase_N PF16891.5 EKE40276.1 - 0.45 11.0 3.8 7.6 7.1 0.2 3.6 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain Spc42p PF11544.8 EKE40276.1 - 0.85 9.7 8.6 0.31 11.1 1.9 3.5 2 0 0 2 2 2 0 Spindle pole body component Spc42p Vps26 PF03643.15 EKE40277.1 - 3.8e-30 104.8 8.7 5.8e-30 104.2 8.7 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EKE40277.1 - 1.3e-06 28.6 3.5 0.00034 20.7 0.1 3.4 2 2 1 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EKE40277.1 - 0.43 11.0 8.3 0.068 13.6 4.1 1.9 2 1 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Pkinase_Tyr PF07714.17 EKE40278.1 - 1.6e-57 194.8 0.2 2.7e-57 194.0 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40278.1 - 1.1e-53 182.3 0.6 2.3e-53 181.3 0.6 1.5 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EKE40278.1 - 9e-23 80.3 4.8 7.2e-08 32.8 0.1 5.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE40278.1 - 1.3e-19 69.9 3.3 1.7e-07 31.3 0.2 5.3 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKE40278.1 - 2.4e-18 66.5 6.4 1.5e-07 31.9 0.2 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EKE40278.1 - 1.4e-14 53.8 2.8 0.036 14.5 0.3 6.5 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 EKE40278.1 - 1.7e-13 49.4 8.7 0.0017 18.7 0.0 7.1 7 0 0 7 7 7 3 Ankyrin repeat FTA2 PF13095.6 EKE40278.1 - 0.0099 15.5 0.8 0.096 12.3 0.1 2.4 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 UQ_con PF00179.26 EKE40279.1 - 5e-42 142.9 0.0 5.8e-42 142.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKE40279.1 - 0.0049 16.6 0.0 0.0055 16.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B Nop PF01798.18 EKE40281.1 - 6.8e-65 218.7 0.3 6.8e-65 218.7 0.3 1.6 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EKE40281.1 - 7.7e-18 65.6 2.6 5e-17 62.9 3.0 2.1 2 0 0 2 2 2 1 Prp31 C terminal domain LPD39 PF18858.1 EKE40281.1 - 0.037 14.1 0.6 0.078 13.1 0.6 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 39 Rubrerythrin PF02915.17 EKE40281.1 - 0.13 12.7 1.6 3.8 7.9 1.0 2.3 2 0 0 2 2 2 0 Rubrerythrin HEPN_Swt1 PF18731.1 EKE40281.1 - 0.22 11.9 0.9 0.47 10.8 0.2 1.9 2 0 0 2 2 2 0 Swt1-like HEPN Metallophos PF00149.28 EKE40282.1 - 4e-23 83.0 0.0 5e-23 82.7 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CitMHS PF03600.16 EKE40283.1 - 7.7e-22 77.9 46.5 2e-15 56.8 17.8 2.5 2 1 0 2 2 2 2 Citrate transporter TrkA_C PF02080.21 EKE40283.1 - 0.0014 18.4 0.1 0.0024 17.6 0.1 1.4 1 0 0 1 1 1 1 TrkA-C domain DUF4014 PF13198.6 EKE40283.1 - 0.57 10.6 2.8 0.45 10.9 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4014) CD20 PF04103.15 EKE40284.1 - 0.42 10.7 16.2 0.76 9.8 16.2 1.4 1 0 0 1 1 1 0 CD20-like family ECSCR PF15820.5 EKE40284.1 - 4.9 7.0 6.4 0.81 9.5 0.1 2.5 3 0 0 3 3 3 0 Endothelial cell-specific chemotaxis regulator DNA_primase_lrg PF04104.14 EKE40285.1 - 3.6e-41 141.3 1.7 6.9e-41 140.4 1.7 1.5 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit N_BRCA1_IG PF16158.5 EKE40287.1 - 4.2e-17 62.7 0.8 7.3e-17 62.0 0.8 1.4 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene v110 PF01639.17 EKE40287.1 - 0.064 13.1 1.8 0.17 11.8 1.5 1.9 1 1 0 1 1 1 0 Viral family 110 KxDL PF10241.9 EKE40288.1 - 0.56 10.5 11.8 0.034 14.4 5.8 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein RNase_PH PF01138.21 EKE40289.1 - 4.3e-12 46.7 0.0 8.7e-12 45.7 0.0 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 Alkyl_sulf_dimr PF14863.6 EKE40290.1 - 2.9e-51 173.6 0.3 4.3e-51 173.0 0.3 1.3 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Alkyl_sulf_C PF14864.6 EKE40290.1 - 6.6e-17 62.0 0.0 1.2e-16 61.1 0.0 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Lactamase_B PF00753.27 EKE40290.1 - 1.6e-11 44.6 0.0 1.2e-10 41.7 0.0 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EKE40290.1 - 0.00036 20.1 0.0 0.00063 19.3 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain SCP2 PF02036.17 EKE40290.1 - 0.057 13.9 0.1 2.4 8.7 0.0 2.4 2 0 0 2 2 2 0 SCP-2 sterol transfer family AAA PF00004.29 EKE40291.1 - 4.8e-15 56.1 0.0 8.4e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EKE40291.1 - 1.8e-13 50.6 0.8 3.1e-11 43.3 0.4 2.3 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 EKE40291.1 - 2.5e-09 37.5 0.2 0.00012 22.4 0.0 2.6 1 1 2 3 3 2 2 AAA domain Rad17 PF03215.15 EKE40291.1 - 4e-06 26.9 0.1 2.5e-05 24.3 0.0 1.8 1 1 1 2 2 2 1 Rad17 P-loop domain DNA_pol3_delta PF06144.13 EKE40291.1 - 6.3e-06 26.1 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 EKE40291.1 - 1.1e-05 25.5 0.1 5.2e-05 23.3 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EKE40291.1 - 1.4e-05 25.5 0.1 0.0005 20.5 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EKE40291.1 - 5.3e-05 23.0 0.0 0.00011 22.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 EKE40291.1 - 0.0001 22.6 0.1 0.00027 21.2 0.1 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_7 PF12775.7 EKE40291.1 - 0.00014 21.4 0.1 0.0032 17.0 0.0 2.5 3 0 0 3 3 3 1 P-loop containing dynein motor region DUF815 PF05673.13 EKE40291.1 - 0.00027 20.2 0.0 0.0011 18.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Rep_fac_C PF08542.11 EKE40291.1 - 0.00041 20.7 0.4 0.0014 19.0 0.1 2.1 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA_5 PF07728.14 EKE40291.1 - 0.00097 19.2 0.0 0.0022 18.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EKE40291.1 - 0.0062 16.3 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EKE40291.1 - 0.0097 15.3 0.0 0.16 11.3 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 EKE40291.1 - 0.012 15.5 0.2 0.11 12.4 0.0 2.5 2 1 1 3 3 3 0 NTPase AAA_3 PF07726.11 EKE40291.1 - 0.013 15.4 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 EKE40291.1 - 0.013 15.2 0.0 0.031 13.9 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain TniB PF05621.11 EKE40291.1 - 0.016 14.6 0.0 0.61 9.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_19 PF13245.6 EKE40291.1 - 0.019 15.3 0.1 0.05 13.9 0.1 1.8 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 EKE40291.1 - 0.023 14.2 0.1 0.035 13.5 0.1 1.5 1 1 0 1 1 1 0 Chromatin associated protein KTI12 MeaB PF03308.16 EKE40291.1 - 0.028 13.4 0.0 0.12 11.3 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 EKE40291.1 - 0.03 14.7 0.0 0.078 13.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DEAD PF00270.29 EKE40291.1 - 0.032 14.0 0.5 1.2 8.8 0.0 2.8 2 1 1 3 3 3 0 DEAD/DEAH box helicase FtsK_SpoIIIE PF01580.18 EKE40291.1 - 0.033 13.5 0.0 0.093 12.1 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_30 PF13604.6 EKE40291.1 - 0.036 13.8 0.0 0.13 11.9 0.0 1.9 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 EKE40291.1 - 0.045 13.7 0.0 0.092 12.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_11 PF13086.6 EKE40291.1 - 0.046 13.5 0.2 0.11 12.3 0.2 1.7 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EKE40291.1 - 0.054 13.2 0.0 0.084 12.6 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RsgA_GTPase PF03193.16 EKE40291.1 - 0.068 13.1 0.0 0.16 11.8 0.0 1.7 1 1 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 EKE40291.1 - 0.084 12.4 0.0 0.22 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EKE40291.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin SAP PF02037.27 EKE40292.1 - 0.00028 20.6 2.1 0.00046 19.9 2.1 1.3 1 0 0 1 1 1 1 SAP domain DUF1765 PF08578.10 EKE40294.1 - 1.5e-17 64.2 6.6 1.5e-17 64.2 6.6 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1765) DUF2120 PF09893.9 EKE40294.1 - 0.24 11.5 4.3 0.23 11.5 0.8 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) Vps35 PF03635.17 EKE40295.1 - 1.7e-118 397.2 49.3 6.2e-118 395.3 49.3 1.7 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Complex1_LYR_2 PF13233.6 EKE40295.1 - 0.26 12.1 1.3 6.3 7.6 0.1 3.3 3 0 0 3 3 3 0 Complex1_LYR-like F_actin_bund_C PF18060.1 EKE40296.1 - 3.1e-18 65.7 24.7 3.1e-18 65.7 24.7 5.3 3 2 2 5 5 5 1 F actin bundling C terminal Alanine_zipper PF11839.8 EKE40296.1 - 0.42 11.0 108.7 0.064 13.6 36.0 5.2 2 2 3 5 5 5 0 Alanine-zipper, major outer membrane lipoprotein HhH-GPD PF00730.25 EKE40297.1 - 1.1e-13 51.6 0.0 1.9e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EKE40297.1 - 1.8e-09 36.9 0.0 5.1e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.7 EKE40297.1 - 0.018 15.1 0.0 0.34 11.0 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif HHH_5 PF14520.6 EKE40297.1 - 0.027 15.1 0.0 0.69 10.6 0.0 2.8 3 0 0 3 3 3 0 Helix-hairpin-helix domain FlaC_arch PF05377.11 EKE40297.1 - 4.2 7.8 7.6 0.48 10.8 2.1 2.3 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) RabGAP-TBC PF00566.18 EKE40298.1 - 4.4e-42 144.2 5.3 9.3e-42 143.1 5.3 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ank_2 PF12796.7 EKE40298.1 - 2.2e-21 76.2 5.8 7.8e-10 39.2 0.4 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE40298.1 - 2.1e-14 53.7 4.4 0.0035 17.9 0.2 5.9 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EKE40298.1 - 5.4e-14 51.9 1.7 3.1e-05 24.2 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EKE40298.1 - 5.5e-14 50.9 4.5 0.01 16.3 0.1 5.7 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 EKE40298.1 - 4.5e-12 46.0 2.2 1.6e-05 25.1 0.2 4.1 2 1 2 4 4 4 4 Ankyrin repeats (many copies) TFIIB PF00382.19 EKE40298.1 - 0.059 13.4 1.2 1.7 8.7 0.1 3.1 1 1 1 2 2 2 0 Transcription factor TFIIB repeat Death_2 PF14786.6 EKE40298.1 - 0.13 12.2 0.1 0.34 10.8 0.1 1.7 1 0 0 1 1 1 0 Tube Death domain PK_C PF02887.16 EKE40299.1 - 0.0052 17.0 0.2 0.24 11.6 0.0 2.5 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain DUF3122 PF11320.8 EKE40299.1 - 0.066 13.3 0.2 0.17 12.0 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3122) HicB_lk_antitox PF15919.5 EKE40301.1 - 0.021 14.9 0.1 0.049 13.7 0.1 1.6 1 0 0 1 1 1 0 HicB_like antitoxin of bacterial toxin-antitoxin system Cauli_DNA-bind PF03310.13 EKE40301.1 - 0.039 14.0 0.2 0.087 12.9 0.2 1.6 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein PP2C_2 PF13672.6 EKE40301.1 - 0.043 13.4 0.0 0.27 10.8 0.0 2.0 1 1 0 1 1 1 0 Protein phosphatase 2C SPRY PF00622.28 EKE40302.1 - 1.2e-09 38.3 0.4 3.2e-09 36.9 0.4 1.7 1 0 0 1 1 1 1 SPRY domain MerR-DNA-bind PF09278.11 EKE40303.1 - 0.0031 18.0 4.0 0.03 14.8 1.5 2.3 1 1 1 2 2 2 1 MerR, DNA binding Osmo_CC PF08946.10 EKE40303.1 - 0.0081 16.4 0.9 0.17 12.2 1.6 2.3 2 0 0 2 2 2 1 Osmosensory transporter coiled coil Baculo_PEP_C PF04513.12 EKE40303.1 - 0.0089 16.1 0.2 0.012 15.6 0.2 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus PNPase PF03726.14 EKE40303.1 - 0.011 16.2 1.3 0.018 15.5 1.3 1.4 1 0 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Apolipoprotein PF01442.18 EKE40303.1 - 0.013 15.4 0.2 0.016 15.1 0.2 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Prominin PF05478.11 EKE40303.1 - 0.032 12.2 0.1 0.033 12.1 0.1 1.0 1 0 0 1 1 1 0 Prominin Methyltransf_5 PF01795.19 EKE40303.1 - 0.035 13.6 0.2 0.039 13.5 0.2 1.1 1 0 0 1 1 1 0 MraW methylase family CdvA PF18822.1 EKE40303.1 - 0.3 10.9 4.4 0.41 10.5 0.7 2.0 1 1 1 2 2 2 0 CdvA-like coiled-coil domain DUF1664 PF07889.12 EKE40303.1 - 0.34 10.9 2.7 1.1 9.3 0.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2680 PF10925.8 EKE40303.1 - 2.8 8.0 5.2 22 5.2 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2680) Ribosomal_L37ae PF01780.19 EKE40304.1 - 4.6e-39 132.4 7.9 5.2e-39 132.2 7.9 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-FPG_IleRS PF06827.14 EKE40304.1 - 0.0011 18.8 0.3 0.0029 17.4 0.3 1.8 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS Zn_Tnp_IS1595 PF12760.7 EKE40304.1 - 0.0072 16.3 6.8 0.011 15.7 6.8 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-RING_13 PF17977.1 EKE40304.1 - 0.023 14.8 3.8 0.033 14.3 3.8 1.2 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain A2L_zn_ribbon PF08792.10 EKE40304.1 - 0.3 10.9 6.1 4 7.3 0.5 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-BED PF02892.15 EKE40304.1 - 0.69 10.0 7.9 0.5 10.4 0.9 2.2 1 1 1 2 2 2 0 BED zinc finger Pkinase PF00069.25 EKE40305.1 - 4.4e-65 219.7 0.0 5.6e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40305.1 - 8.6e-31 107.2 0.0 1.6e-29 103.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EKE40305.1 - 0.00086 18.7 0.1 0.0015 18.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EKE40305.1 - 0.0028 17.0 0.0 0.007 15.7 0.0 1.6 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 EKE40305.1 - 0.0086 16.0 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EKE40305.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 EKE40305.1 - 0.038 12.9 0.0 0.077 11.9 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain MIG-14_Wnt-bd PF06664.12 EKE40306.1 - 2.5e-13 49.9 30.0 2.5e-13 49.9 30.0 2.0 2 0 0 2 2 2 2 Wnt-binding factor required for Wnt secretion Pkinase PF00069.25 EKE40307.1 - 4.5e-60 203.2 0.0 9.5e-60 202.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40307.1 - 1.3e-37 129.5 0.2 3e-37 128.3 0.1 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE40307.1 - 4.4e-05 22.9 0.0 0.00012 21.5 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EKE40307.1 - 0.00029 19.7 0.0 0.00039 19.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EKE40307.1 - 0.0011 18.0 0.2 0.0021 17.1 0.2 1.4 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase APH PF01636.23 EKE40307.1 - 0.0015 18.5 0.0 0.0031 17.5 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family ABC1 PF03109.16 EKE40307.1 - 0.1 12.8 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 ABC1 family Ras PF00071.22 EKE40308.1 - 3.1e-52 176.4 0.0 3.7e-52 176.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40308.1 - 2.2e-32 111.8 0.1 5.2e-32 110.6 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40308.1 - 2e-13 50.1 0.0 2.8e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE40308.1 - 8.3e-05 22.6 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE40308.1 - 0.00072 19.1 1.2 0.0055 16.3 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain G-alpha PF00503.20 EKE40308.1 - 0.0032 16.7 1.4 0.65 9.1 0.1 2.5 2 1 1 3 3 3 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EKE40308.1 - 0.0033 16.8 0.0 0.0046 16.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RNA_helicase PF00910.22 EKE40308.1 - 0.013 15.9 0.4 0.082 13.3 0.4 2.1 1 1 0 1 1 1 0 RNA helicase ATP_bind_1 PF03029.17 EKE40308.1 - 0.025 14.4 0.1 3.5 7.4 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Pox_A32 PF04665.12 EKE40308.1 - 0.026 14.0 0.1 0.046 13.2 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_24 PF13479.6 EKE40308.1 - 0.035 13.8 0.3 0.052 13.3 0.2 1.4 1 1 0 1 1 1 0 AAA domain ArgoMid PF16487.5 EKE40308.1 - 0.035 14.3 0.1 0.062 13.6 0.1 1.4 1 0 0 1 1 1 0 Mid domain of argonaute RsgA_GTPase PF03193.16 EKE40308.1 - 0.049 13.5 0.1 9.2 6.1 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 EKE40308.1 - 0.055 13.0 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Septin PF00735.18 EKE40308.1 - 0.071 12.4 0.1 0.14 11.4 0.0 1.5 2 0 0 2 2 2 0 Septin AAA_33 PF13671.6 EKE40308.1 - 0.11 12.6 0.3 0.16 12.1 0.3 1.5 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EKE40308.1 - 0.15 11.4 0.1 0.27 10.6 0.0 1.4 2 0 0 2 2 2 0 KaiC AAA_22 PF13401.6 EKE40308.1 - 0.18 12.1 0.2 0.52 10.6 0.1 1.9 1 1 1 2 2 2 0 AAA domain WD40 PF00400.32 EKE40310.1 - 1.2e-05 25.9 0.1 0.52 11.3 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat Cullin PF00888.22 EKE40311.1 - 2.3e-73 247.9 15.2 3.7e-73 247.2 15.2 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EKE40311.1 - 6.9e-18 64.5 2.9 6.9e-18 64.5 2.9 2.9 2 0 0 2 2 2 1 Cullin protein neddylation domain DUF3658 PF12395.8 EKE40311.1 - 0.028 14.3 0.4 0.068 13.1 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function Tugs PF17840.1 EKE40311.1 - 0.16 12.2 0.2 0.51 10.6 0.0 1.9 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain Myb_DNA-binding PF00249.31 EKE40313.1 - 1.1e-09 38.4 0.6 2.9e-09 37.0 0.2 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE40313.1 - 2.1e-05 24.7 0.4 6.8e-05 23.0 0.4 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain SLIDE PF09111.10 EKE40313.1 - 0.003 17.6 6.8 0.0081 16.2 5.7 2.4 1 1 1 2 2 2 1 SLIDE Med19 PF10278.9 EKE40313.1 - 0.0046 16.9 3.4 0.0046 16.9 3.4 1.9 2 0 0 2 2 2 1 Mediator of RNA pol II transcription subunit 19 Myb_DNA-bind_5 PF13873.6 EKE40313.1 - 0.034 14.2 3.5 1.1 9.3 0.5 3.1 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain RR_TM4-6 PF06459.12 EKE40313.1 - 0.67 9.7 8.8 1.3 8.8 8.8 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2992 PF11208.8 EKE40313.1 - 3.2 8.0 15.2 0.64 10.3 11.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) Alpha_kinase PF02816.18 EKE40314.1 - 1.4e-30 106.8 2.7 1.4e-30 106.8 2.7 3.3 3 1 0 3 3 3 1 Alpha-kinase family Citrate_ly_lig PF08218.11 EKE40314.1 - 0.013 15.2 4.1 0.77 9.4 0.5 3.3 2 1 0 2 2 2 0 Citrate lyase ligase C-terminal domain MIF4G PF02854.19 EKE40315.1 - 9.7e-10 38.4 8.4 9.7e-10 38.4 8.4 2.2 3 0 0 3 3 3 1 MIF4G domain DUF3289 PF11692.8 EKE40315.1 - 0.0011 18.6 0.7 0.003 17.2 0.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3289) Erp_C PF06780.11 EKE40315.1 - 8.8 6.3 10.6 0.63 10.1 0.3 3.5 4 0 0 4 4 4 0 Erp protein C-terminus PP2C PF00481.21 EKE40316.1 - 3.3e-37 128.5 0.0 5.5e-37 127.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 EKE40316.1 - 1.7e-34 117.3 115.1 1.7e-05 25.1 2.9 12.9 8 2 5 13 13 13 13 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE40316.1 - 4e-31 106.6 95.9 4.1e-07 29.7 2.9 10.6 6 2 7 13 13 13 12 Leucine rich repeat LRR_1 PF00560.33 EKE40316.1 - 0.00028 21.0 86.5 0.23 12.1 0.3 17.8 16 5 2 18 18 18 6 Leucine Rich Repeat LRR_9 PF14580.6 EKE40316.1 - 0.0035 16.9 34.3 0.17 11.4 0.5 5.9 1 1 4 6 6 6 4 Leucine-rich repeat Kelch_4 PF13418.6 EKE40316.1 - 4.2 7.5 5.1 10 6.2 0.0 3.8 4 0 0 4 4 4 0 Galactose oxidase, central domain CDP-OH_P_transf PF01066.21 EKE40317.1 - 2.5e-14 53.8 0.4 2.5e-14 53.8 0.4 3.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Ras PF00071.22 EKE40318.1 - 0.0043 16.7 0.1 0.0089 15.6 0.1 1.5 1 0 0 1 1 1 1 Ras family Cyclin_C_2 PF16899.5 EKE40318.1 - 0.0094 16.3 0.2 0.035 14.5 0.1 2.1 2 0 0 2 2 2 1 Cyclin C-terminal domain UPF0160 PF03690.13 EKE40320.1 - 4.1e-53 181.1 0.0 5.6e-53 180.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) LRR_9 PF14580.6 EKE40321.1 - 3.9e-05 23.2 1.9 3.9e-05 23.2 1.9 2.6 2 1 1 3 3 3 1 Leucine-rich repeat NTF2 PF02136.20 EKE40321.1 - 0.00026 21.6 0.0 0.0026 18.3 0.0 2.6 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_9 PF18444.1 EKE40321.1 - 0.0092 15.8 0.4 0.023 14.5 0.4 1.7 1 0 0 1 1 1 1 RNA recognition motif DUF5051 PF16473.5 EKE40321.1 - 0.063 13.3 0.1 0.41 10.6 0.1 2.2 1 1 0 1 1 1 0 3' exoribonuclease, RNase T-like LRR_4 PF12799.7 EKE40321.1 - 0.21 12.0 13.7 0.29 11.6 2.2 4.3 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE40321.1 - 0.57 10.0 6.7 1.6 8.5 5.4 2.7 2 1 0 2 2 2 0 Leucine rich repeat Pkinase PF00069.25 EKE40322.1 - 1.9e-38 132.4 0.0 2.3e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40322.1 - 7.4e-14 51.6 0.0 1.1e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EKE40322.1 - 0.0035 17.3 0.0 1.5 8.7 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EKE40322.1 - 0.11 12.0 0.3 0.27 10.8 0.1 1.7 2 0 0 2 2 2 0 RIO1 family Sec23_BS PF08033.12 EKE40324.1 - 2.5e-08 34.6 0.1 2.3e-07 31.5 0.0 2.3 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Clathrin_bdg PF15045.6 EKE40324.1 - 0.0087 16.0 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 Clathrin-binding box of Aftiphilin, vesicle trafficking CH_2 PF06294.11 EKE40324.1 - 0.089 12.9 0.5 0.38 10.9 0.2 2.2 2 0 0 2 2 2 0 CH-like domain in sperm protein zf-Sec23_Sec24 PF04810.15 EKE40324.1 - 0.21 11.6 7.7 0.6 10.2 7.7 1.8 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Adaptin_N PF01602.20 EKE40325.1 - 3e-93 313.2 13.6 3.7e-93 312.9 13.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EKE40325.1 - 2.7e-23 82.3 0.0 9.8e-23 80.5 0.0 2.1 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Cnd1 PF12717.7 EKE40325.1 - 2.1e-11 44.1 8.6 1.9e-08 34.5 0.1 3.7 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 EKE40325.1 - 0.00057 19.9 0.0 0.0016 18.5 0.0 1.8 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain IFRD PF05004.13 EKE40325.1 - 0.082 12.0 0.1 0.19 10.8 0.1 1.6 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) Humanin PF15040.6 EKE40325.1 - 0.089 12.2 0.5 0.18 11.3 0.5 1.5 1 0 0 1 1 1 0 Humanin family Pkinase PF00069.25 EKE40328.1 - 0.00079 18.9 0.0 0.0016 17.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Toxin_YhaV PF11663.8 EKE40328.1 - 0.054 13.6 0.3 9.6 6.3 0.0 2.7 2 1 1 3 3 3 0 Toxin with endonuclease activity, of toxin-antitoxin system MotY_N PF18393.1 EKE40328.1 - 0.093 12.9 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 MotY N-terminal domain PhoLip_ATPase_C PF16212.5 EKE40329.1 - 3.3e-53 181.0 26.9 3.3e-53 181.0 26.9 2.9 3 0 0 3 3 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EKE40329.1 - 1.1e-17 63.5 12.5 6.5e-17 61.0 7.1 3.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EKE40329.1 - 4.1e-15 56.6 2.1 2e-11 44.6 2.1 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EKE40329.1 - 1.3e-10 41.1 1.1 4.1e-10 39.5 0.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EKE40329.1 - 1.5e-07 31.4 0.2 7.3e-07 29.2 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EKE40329.1 - 7.7e-07 29.1 1.4 0.00045 20.0 0.0 2.4 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EKE40329.1 - 0.0074 16.4 0.5 0.5 10.4 0.1 2.9 1 1 1 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EKE40329.1 - 0.031 14.7 0.0 2.2 8.7 0.0 2.8 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase THP2 PF09432.10 EKE40329.1 - 0.052 13.6 0.1 0.052 13.6 0.1 2.1 2 0 0 2 2 2 0 Tho complex subunit THP2 Glyco_tran_WecB PF03808.13 EKE40329.1 - 0.14 12.1 0.2 0.43 10.5 0.2 1.9 1 1 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family Methyltransf_5 PF01795.19 EKE40329.1 - 0.14 11.6 0.5 0.25 10.8 0.5 1.3 1 0 0 1 1 1 0 MraW methylase family NPBW PF15180.6 EKE40329.1 - 0.16 11.8 0.0 0.45 10.4 0.0 1.7 1 0 0 1 1 1 0 Neuropeptides B and W Attractin PF08037.11 EKE40329.1 - 2.5 8.2 6.5 1.8 8.6 0.9 2.4 1 1 0 2 2 2 0 Attractin family Spc7 PF08317.11 EKE40330.1 - 0.0007 18.6 23.6 0.0007 18.6 23.6 2.3 1 1 1 2 2 2 1 Spc7 kinetochore protein Rhodanese PF00581.20 EKE40332.1 - 2e-07 31.5 0.6 1e-06 29.2 0.0 2.5 2 0 0 2 2 2 1 Rhodanese-like domain RabGAP-TBC PF00566.18 EKE40332.1 - 3.1e-05 23.8 7.1 3.1e-05 23.8 7.1 2.9 3 0 0 3 3 3 1 Rab-GTPase-TBC domain DDHD PF02862.17 EKE40332.1 - 0.083 13.0 9.0 0.16 12.1 9.0 1.5 1 0 0 1 1 1 0 DDHD domain Methyltransf_32 PF13679.6 EKE40332.1 - 2.9 7.9 7.2 6.2 6.8 7.2 1.5 1 0 0 1 1 1 0 Methyltransferase domain CDC27 PF09507.10 EKE40332.1 - 5.3 6.3 40.0 25 4.1 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 DUF4661 PF15576.6 EKE40332.1 - 8.7 6.2 8.0 12 5.7 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) zf-C2H2_2 PF12756.7 EKE40333.1 - 1.2e-26 92.9 31.9 5.7e-24 84.4 10.7 3.0 2 1 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EKE40333.1 - 1e-09 38.4 18.8 2.9e-08 33.8 7.2 3.0 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EKE40333.1 - 1.1e-08 35.2 15.2 3.7e-07 30.3 4.5 3.1 2 0 0 2 2 2 2 Zinc-finger of C2H2 type AKAP95 PF04988.12 EKE40333.1 - 0.072 13.3 0.6 0.072 13.3 0.6 3.6 4 0 0 4 4 4 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_4 PF13894.6 EKE40333.1 - 0.094 13.6 0.7 0.094 13.6 0.7 5.2 5 0 0 5 5 5 0 C2H2-type zinc finger Clr5 PF14420.6 EKE40333.1 - 0.28 11.4 3.8 5.8 7.2 0.2 3.1 3 0 0 3 3 3 0 Clr5 domain Exonuc_VII_L PF02601.15 EKE40335.1 - 0.081 12.5 3.5 0.081 12.5 3.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF948 PF06103.11 EKE40335.1 - 0.094 13.0 1.9 0.14 12.4 1.9 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Apo-VLDL-II PF05418.11 EKE40335.1 - 0.12 12.9 0.8 0.18 12.4 0.8 1.2 1 0 0 1 1 1 0 Apovitellenin I (Apo-VLDL-II) DUF1043 PF06295.12 EKE40335.1 - 1.5 8.8 8.0 2.7 8.0 8.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) mRNA_cap_enzyme PF01331.19 EKE40336.1 - 6.5e-19 68.5 2.4 1.7e-18 67.2 2.4 1.7 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EKE40336.1 - 0.00096 19.8 0.3 0.00096 19.8 0.3 2.6 2 0 0 2 2 2 1 mRNA capping enzyme, C-terminal domain Cofilin_ADF PF00241.20 EKE40338.1 - 2.2e-10 40.4 0.0 2.5e-10 40.2 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Shugoshin_N PF07558.11 EKE40339.1 - 0.0049 16.7 1.6 0.0049 16.7 1.6 3.3 3 0 0 3 3 3 1 Shugoshin N-terminal coiled-coil region DUF1664 PF07889.12 EKE40339.1 - 0.64 10.1 6.1 1.7 8.7 6.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 EKE40339.1 - 0.71 8.7 14.5 0.93 8.3 14.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2284 PF10050.9 EKE40339.1 - 7.6 6.2 9.0 0.96 9.2 0.0 2.9 2 1 1 3 3 3 0 Predicted metal-binding protein (DUF2284) CRA PF06589.11 EKE40340.1 - 0.044 13.9 4.7 0.083 13.0 4.7 1.5 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) HEAT_2 PF13646.6 EKE40341.1 - 3e-05 24.3 0.0 0.25 11.7 0.0 3.3 3 1 0 3 3 3 2 HEAT repeats Telomere_reg-2 PF10193.9 EKE40341.1 - 0.043 14.3 0.0 0.16 12.4 0.0 2.0 1 0 0 1 1 1 0 Telomere length regulation protein Glyco_hydro_65m PF03632.15 EKE40342.1 - 0.091 11.6 1.8 0.11 11.4 1.8 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65 central catalytic domain DUF2680 PF10925.8 EKE40342.1 - 2.4 8.2 12.8 0.1 12.6 1.6 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2680) H_lectin PF09458.10 EKE40343.1 - 2.6e-07 30.7 11.7 2.5e-06 27.6 1.5 3.7 3 0 0 3 3 3 2 H-type lectin domain zf-C3HC4_3 PF13920.6 EKE40343.1 - 0.00055 19.8 18.3 0.0015 18.4 18.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF4781 PF16013.5 EKE40343.1 - 0.016 14.0 3.2 0.025 13.4 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) MRP-S34 PF16053.5 EKE40343.1 - 0.088 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S34 Mu-like_Com PF10122.9 EKE40343.1 - 0.78 9.2 9.8 2 8.0 8.6 2.0 2 0 0 2 2 2 0 Mu-like prophage protein Com CK_II_beta PF01214.18 EKE40344.1 - 5.2e-63 212.1 0.0 6.1e-63 211.9 0.0 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit TLD PF07534.16 EKE40345.1 - 2.2e-06 27.9 0.5 4.6e-06 26.9 0.4 1.6 1 1 0 1 1 1 1 TLD DUF3837 PF12939.7 EKE40345.1 - 0.091 13.2 1.6 0.21 12.0 1.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3837) LANC_like PF05147.13 EKE40345.1 - 0.3 9.6 3.2 0.3 9.6 0.4 1.9 2 0 0 2 2 2 0 Lanthionine synthetase C-like protein Adaptin_N PF01602.20 EKE40346.1 - 1.5e-129 433.0 15.1 1.5e-129 433.0 15.1 1.4 2 0 0 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.7 EKE40346.1 - 3e-55 186.7 5.8 7.7e-55 185.4 0.1 3.2 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKE40346.1 - 7.3e-14 51.9 0.1 3.8e-06 27.2 0.0 5.8 3 2 3 6 6 6 3 HEAT repeats HEAT PF02985.22 EKE40346.1 - 1.9e-08 33.8 4.5 0.093 13.0 0.0 6.3 7 0 0 7 7 7 2 HEAT repeat Arm PF00514.23 EKE40346.1 - 7e-05 22.7 0.4 22 5.2 0.0 5.6 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat B2-adapt-app_C PF09066.10 EKE40346.1 - 0.00067 19.7 0.3 0.0018 18.4 0.3 1.8 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain Alpha_adaptinC2 PF02883.20 EKE40346.1 - 0.0009 19.5 0.1 0.0024 18.2 0.1 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_EZ PF13513.6 EKE40346.1 - 0.0017 18.8 0.1 1.4 9.5 0.0 5.1 5 1 1 6 6 6 1 HEAT-like repeat CLASP_N PF12348.8 EKE40346.1 - 0.015 14.9 0.1 1.5 8.4 0.0 2.8 2 0 0 2 2 2 0 CLASP N terminal GUN4_N PF16416.5 EKE40346.1 - 0.12 12.3 0.0 8.8 6.4 0.0 2.8 2 0 0 2 2 2 0 ARM-like repeat domain, GUN4-N terminal PBP1_TM PF14812.6 EKE40347.1 - 0.025 14.9 15.3 0.11 12.9 3.1 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal KIAA1430 PF13879.6 EKE40347.1 - 0.028 15.2 10.3 0.028 15.2 10.3 2.4 2 1 0 2 2 2 0 KIAA1430 homologue Fam20C PF06702.12 EKE40347.1 - 0.066 13.0 4.6 0.13 12.1 0.3 2.2 2 0 0 2 2 2 0 Golgi casein kinase, C-terminal, Fam20 Ras PF00071.22 EKE40348.1 - 1.4e-41 141.8 1.0 1.9e-41 141.4 1.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40348.1 - 3.3e-18 66.0 0.4 3.3e-18 66.0 0.4 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40348.1 - 1.5e-10 40.8 0.3 2.1e-10 40.4 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE40348.1 - 8.6e-06 25.8 0.1 0.038 13.9 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE40348.1 - 0.0044 17.1 0.0 0.011 15.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EKE40348.1 - 0.0099 15.2 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 1 Septin SRPRB PF09439.10 EKE40348.1 - 0.014 14.8 0.0 0.018 14.4 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EKE40348.1 - 0.028 13.9 0.0 0.052 13.0 0.0 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 EKE40348.1 - 0.076 12.5 0.4 9.7 5.7 0.0 2.4 2 1 0 2 2 2 0 Ferrous iron transport protein B HTH_Tnp_1 PF01527.20 EKE40349.1 - 0.032 14.5 0.1 0.13 12.6 0.1 2.0 1 1 0 1 1 1 0 Transposase DUF775 PF05603.12 EKE40349.1 - 0.091 12.3 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) DnaT PF17948.1 EKE40349.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 DnaT DNA-binding domain Mid2 PF04478.12 EKE40350.1 - 1.3 8.8 4.7 11 5.8 1.2 2.6 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Y_phosphatase PF00102.27 EKE40351.1 - 4e-53 180.4 0.5 4.8e-52 176.9 0.5 2.0 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EKE40351.1 - 3.3e-05 23.7 1.1 0.0011 18.8 0.0 2.6 1 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain T3SchapCesA PF11439.8 EKE40351.1 - 0.009 16.1 0.7 0.019 15.1 0.7 1.5 1 0 0 1 1 1 1 Type III secretion system filament chaperone CesA Coatomer_WDAD PF04053.14 EKE40352.1 - 1.4e-101 340.8 0.1 5.2e-101 338.9 0.0 1.8 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EKE40352.1 - 5.3e-43 144.2 15.5 1.9e-08 34.8 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE40352.1 - 1.5e-10 41.2 1.1 0.00023 21.4 0.1 5.6 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 EKE40352.1 - 0.01 14.9 0.0 0.11 11.5 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1513) Nup160 PF11715.8 EKE40352.1 - 0.08 11.6 9.1 4.6 5.8 0.2 4.7 5 1 1 6 6 6 0 Nucleoporin Nup120/160 U3_assoc_6 PF08640.11 EKE40353.1 - 0.0012 18.8 2.6 0.0014 18.7 2.6 1.2 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 6 B3_4 PF03483.17 EKE40353.1 - 0.0015 18.2 0.1 0.0018 18.0 0.1 1.0 1 0 0 1 1 1 1 B3/4 domain TLD PF07534.16 EKE40354.1 - 0.00084 19.6 2.9 0.0011 19.1 0.6 2.2 1 1 1 2 2 2 1 TLD Beta_protein PF14350.6 EKE40354.1 - 0.18 11.2 2.6 0.27 10.6 2.2 1.4 1 1 0 1 1 1 0 Beta protein AAA_11 PF13086.6 EKE40354.1 - 0.29 10.9 5.2 0.4 10.4 5.2 1.1 1 0 0 1 1 1 0 AAA domain MAP17 PF15807.5 EKE40354.1 - 0.45 10.8 6.1 39 4.5 0.0 2.3 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DEAD PF00270.29 EKE40355.1 - 2.3e-35 121.9 0.2 3.7e-34 118.0 0.2 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE40355.1 - 6.4e-28 97.3 0.9 9.3e-26 90.4 0.1 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE40355.1 - 4.9e-08 33.2 0.0 9.1e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EKE40355.1 - 0.0067 15.8 0.7 0.015 14.6 0.0 1.8 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit DNA_pol_D_N PF18018.1 EKE40355.1 - 0.071 13.2 0.4 7.6 6.6 0.0 3.4 3 1 0 3 3 3 0 DNA polymerase delta subunit OB-fold domain AAA PF00004.29 EKE40356.1 - 5.6e-38 130.4 0.0 2e-37 128.6 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EKE40356.1 - 1.1e-10 41.3 0.1 8.5e-10 38.5 0.0 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EKE40356.1 - 1.6e-06 27.8 0.0 5.3e-06 26.1 0.0 2.0 1 1 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EKE40356.1 - 6.3e-06 26.2 0.1 4.1e-05 23.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EKE40356.1 - 2e-05 24.4 0.0 4.7e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 EKE40356.1 - 0.00013 22.0 0.2 0.027 14.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_2 PF07724.14 EKE40356.1 - 0.00015 22.0 0.0 0.00058 20.0 0.0 2.1 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EKE40356.1 - 0.00018 21.8 0.5 0.027 14.8 0.0 2.7 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 EKE40356.1 - 0.0016 17.7 0.0 0.0035 16.6 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 EKE40356.1 - 0.0031 17.9 0.4 0.04 14.3 0.4 2.5 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 EKE40356.1 - 0.014 14.8 0.3 0.032 13.6 0.3 1.6 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EKE40356.1 - 0.02 15.5 0.1 0.085 13.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EKE40356.1 - 0.02 14.6 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain TniB PF05621.11 EKE40356.1 - 0.021 14.2 0.4 2.8 7.3 0.0 2.7 2 1 0 3 3 3 0 Bacterial TniB protein AAA_19 PF13245.6 EKE40356.1 - 0.024 15.0 0.0 0.077 13.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EKE40356.1 - 0.045 13.5 0.0 0.095 12.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 EKE40356.1 - 0.053 13.0 0.0 0.19 11.2 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Cytidylate_kin PF02224.18 EKE40356.1 - 0.089 12.5 0.2 1.6 8.4 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase aGPT-Pplase3 PF18746.1 EKE40356.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 AAA_30 PF13604.6 EKE40356.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RhoGAP PF00620.27 EKE40357.1 - 8.4e-33 113.3 0.0 1.3e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Exo84_C PF16528.5 EKE40359.1 - 1.3e-11 44.7 5.3 1.3e-11 44.7 5.3 2.2 2 1 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EKE40359.1 - 1.2e-07 31.7 2.1 1.2e-07 31.7 2.1 3.5 2 1 1 3 3 3 1 Vps51/Vps67 Dor1 PF04124.12 EKE40359.1 - 9.5e-07 27.8 11.4 1.9e-06 26.8 11.4 1.5 1 0 0 1 1 1 1 Dor1-like family FUSC PF04632.12 EKE40359.1 - 0.0011 17.6 0.0 0.0014 17.3 0.0 1.1 1 0 0 1 1 1 1 Fusaric acid resistance protein family COG2 PF06148.11 EKE40359.1 - 0.0015 18.6 2.3 0.0015 18.6 2.3 3.0 2 2 1 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Myb_DNA-bind_7 PF15963.5 EKE40359.1 - 0.014 15.3 1.1 0.074 13.0 1.1 2.2 1 0 0 1 1 1 0 Myb DNA-binding like DUF3583 PF12126.8 EKE40359.1 - 0.026 14.0 2.8 0.056 12.9 2.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3583) KMP11 PF03037.16 EKE40359.1 - 0.14 13.0 5.2 9.3 7.1 0.5 3.5 2 1 1 3 3 3 0 Kinetoplastid membrane protein 11 SKA2 PF16740.5 EKE40359.1 - 0.17 11.6 9.7 0.11 12.3 1.6 3.2 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 2 AAA_18 PF13238.6 EKE40359.1 - 0.3 11.6 5.6 0.062 13.9 1.2 2.1 2 1 0 2 2 2 0 AAA domain ABC_tran_CTD PF16326.5 EKE40359.1 - 0.48 10.7 5.3 2.2 8.6 0.4 3.7 3 1 1 4 4 3 0 ABC transporter C-terminal domain Baculo_PEP_C PF04513.12 EKE40359.1 - 0.5 10.4 14.7 0.021 14.9 4.0 3.3 2 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 EKE40359.1 - 1.1 9.4 12.8 0.25 11.4 0.5 4.4 3 1 1 5 5 5 0 Protein of unknown function (DUF1664) Cep57_CLD_2 PF14197.6 EKE40359.1 - 1.1 9.4 7.1 0.13 12.4 0.4 3.0 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 bZIP_1 PF00170.21 EKE40359.1 - 1.7 8.8 7.7 2.1 8.5 0.1 4.3 4 0 0 4 4 4 0 bZIP transcription factor UPF0449 PF15136.6 EKE40359.1 - 2.9 8.4 11.4 13 6.3 0.1 3.7 2 1 2 4 4 4 0 Uncharacterised protein family UPF0449 Fib_alpha PF08702.10 EKE40359.1 - 3 8.0 26.3 0.15 12.3 0.9 4.2 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family COG5 PF10392.9 EKE40359.1 - 4 7.6 17.4 0.43 10.8 1.5 3.5 2 1 1 3 3 3 0 Golgi transport complex subunit 5 Methyltransf_PK PF05891.12 EKE40360.1 - 6e-46 156.7 1.2 6.9e-46 156.5 1.2 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EKE40360.1 - 2.9e-09 37.5 0.0 4.7e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKE40360.1 - 7.2e-09 36.2 0.0 1.1e-08 35.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EKE40360.1 - 2.1e-08 34.8 0.1 4e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EKE40360.1 - 2.1e-07 30.5 0.0 2.7e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 EKE40360.1 - 2.5e-07 30.7 0.1 3.2e-07 30.3 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EKE40360.1 - 6.2e-06 25.7 0.2 1e-05 25.1 0.2 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB NodS PF05401.11 EKE40360.1 - 0.00031 20.4 0.0 0.00043 19.9 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 EKE40360.1 - 0.0039 16.8 0.0 0.0078 15.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain DOT1 PF08123.13 EKE40360.1 - 0.011 15.3 0.1 0.6 9.6 0.1 2.1 1 1 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_31 PF13847.6 EKE40360.1 - 0.012 15.4 0.1 0.021 14.6 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain Bin3 PF06859.12 EKE40360.1 - 0.022 15.4 0.3 0.11 13.1 0.1 2.2 2 1 0 2 2 2 0 Bicoid-interacting protein 3 (Bin3) DUF3052 PF11253.8 EKE40360.1 - 0.076 12.9 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) Coat_F PF07875.12 EKE40360.1 - 0.12 12.6 2.7 0.89 9.8 0.1 3.1 2 1 1 3 3 3 0 Coat F domain Methyltransf_24 PF13578.6 EKE40360.1 - 0.15 13.1 0.0 0.22 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AlphaC_C PF17480.2 EKE40361.1 - 0.00055 19.9 0.1 0.0016 18.4 0.1 1.8 1 0 0 1 1 1 1 AlphaC C-terminal TUDOR PF00567.24 EKE40361.1 - 0.052 13.6 0.1 0.19 11.8 0.0 1.9 1 1 1 2 2 2 0 Tudor domain TMEM215 PF15746.5 EKE40361.1 - 0.058 12.9 0.7 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 TMEM215 family PilJ_C PF18223.1 EKE40361.1 - 0.11 13.0 0.8 0.11 13.0 0.8 3.0 2 1 0 2 2 2 0 Pili PilJ C-terminal domain Viral_env_E26 PF11050.8 EKE40362.1 - 0.018 14.4 2.7 0.028 13.8 2.7 1.2 1 0 0 1 1 1 0 Virus envelope protein E26 DUF1759 PF03564.15 EKE40362.1 - 0.031 14.2 1.3 0.048 13.6 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) DUF1216 PF06746.11 EKE40362.1 - 0.052 13.6 8.9 0.083 12.9 8.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1216) Alkyl_sulf_dimr PF14863.6 EKE40363.1 - 6.1e-49 166.0 0.0 9.2e-49 165.5 0.0 1.3 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Lactamase_B PF00753.27 EKE40363.1 - 6.3e-14 52.4 0.1 2.3e-12 47.4 0.1 2.8 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Alkyl_sulf_C PF14864.6 EKE40363.1 - 8e-14 52.0 0.0 1.7e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Lactamase_B_2 PF12706.7 EKE40363.1 - 6.7e-08 32.3 0.0 1.1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain ANAPC3 PF12895.7 EKE40363.1 - 0.00071 19.7 0.1 0.0015 18.7 0.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Form_Nir_trans PF01226.17 EKE40364.1 - 2.8e-63 213.4 22.7 3.5e-63 213.1 22.7 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter CoA_binding_3 PF13727.6 EKE40364.1 - 7.3 6.6 7.8 0.4 10.7 1.0 2.1 2 0 0 2 2 2 0 CoA-binding domain Helicase_C PF00271.31 EKE40365.1 - 3.5e-22 78.9 0.1 5.1e-19 68.7 0.0 3.2 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.29 EKE40365.1 - 3.1e-19 69.4 0.3 1.5e-18 67.1 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EKE40365.1 - 4.1e-05 24.2 4.8 4.1e-05 24.2 4.8 2.2 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.15 EKE40365.1 - 0.0002 21.4 2.9 0.00024 21.1 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Response_reg PF00072.24 EKE40365.1 - 0.095 12.9 0.1 7.5 6.8 0.0 3.5 4 0 0 4 4 4 0 Response regulator receiver domain MMR_HSR1 PF01926.23 EKE40366.1 - 2.2e-13 50.3 0.0 3.6e-12 46.4 0.0 2.8 3 0 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE40366.1 - 5.8e-07 29.6 1.0 0.013 15.4 0.1 2.7 2 1 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EKE40366.1 - 9e-06 25.3 0.3 0.00031 20.3 0.0 2.6 3 0 0 3 3 3 1 Ferrous iron transport protein B MeaB PF03308.16 EKE40366.1 - 0.39 9.6 2.8 0.41 9.6 0.0 2.4 2 2 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB GRDP-like PF07173.12 EKE40366.1 - 3.5 8.3 8.9 0.35 11.5 2.6 2.3 2 1 0 2 2 2 0 Glycine-rich domain-containing protein-like HHH PF00633.23 EKE40367.1 - 1.9e-07 30.6 0.0 5.4e-07 29.2 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif HhH-GPD PF00730.25 EKE40367.1 - 0.0002 21.7 0.0 0.00039 20.9 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Cdd1 PF11731.8 EKE40367.1 - 0.00074 19.7 0.0 0.0025 18.0 0.0 1.9 2 0 0 2 2 2 1 Pathogenicity locus HHH_5 PF14520.6 EKE40367.1 - 0.0019 18.8 0.0 0.0085 16.7 0.0 2.1 1 0 0 1 1 1 1 Helix-hairpin-helix domain IMS_HHH PF11798.8 EKE40367.1 - 0.011 16.0 0.2 0.1 13.0 0.1 2.4 2 0 0 2 2 2 0 IMS family HHH motif HHH_3 PF12836.7 EKE40367.1 - 0.12 12.7 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif WD40 PF00400.32 EKE40369.1 - 2.6e-09 37.5 3.0 0.0047 17.7 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat WD40_like PF17005.5 EKE40369.1 - 3.7e-05 23.2 1.8 0.00058 19.3 1.1 2.9 1 1 1 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 EKE40369.1 - 0.0015 18.8 0.1 7 7.0 0.0 3.6 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ADAM_CR PF08516.12 EKE40370.1 - 0.016 15.6 0.1 0.016 15.6 0.1 3.1 3 0 0 3 3 3 0 ADAM cysteine-rich PH_10 PF15411.6 EKE40370.1 - 0.11 12.8 0.5 0.49 10.7 0.0 2.3 3 0 0 3 3 3 0 Pleckstrin homology domain Cofilin_ADF PF00241.20 EKE40373.1 - 3.9e-09 36.4 0.0 4.6e-09 36.1 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Crystall PF00030.19 EKE40373.1 - 0.073 13.3 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Beta/Gamma crystallin Wzy_C PF04932.15 EKE40375.1 - 0.003 17.2 2.2 0.0045 16.6 2.2 1.3 1 0 0 1 1 1 1 O-Antigen ligase DUF4750 PF15938.5 EKE40375.1 - 0.13 11.9 3.1 0.21 11.2 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) WD40 PF00400.32 EKE40376.1 - 3.6e-16 59.3 2.1 9.6e-05 23.1 0.1 5.2 6 0 0 6 6 6 2 WD domain, G-beta repeat PQQ_3 PF13570.6 EKE40376.1 - 0.00059 20.2 0.2 0.035 14.6 0.0 2.7 2 0 0 2 2 2 1 PQQ-like domain WD40_like PF17005.5 EKE40376.1 - 0.0025 17.2 0.1 0.54 9.5 0.0 3.0 3 0 0 3 3 3 1 WD40-like domain ANAPC4_WD40 PF12894.7 EKE40376.1 - 0.005 17.1 0.0 5.4 7.4 0.0 3.4 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EKE40376.1 - 0.046 13.7 0.0 0.31 11.1 0.0 2.3 2 0 0 2 2 2 0 PQQ enzyme repeat Cytochrom_D1 PF02239.16 EKE40376.1 - 0.18 10.3 0.0 1.9 6.9 0.0 2.4 2 2 1 3 3 3 0 Cytochrome D1 heme domain DUF1282 PF06930.12 EKE40377.1 - 0.011 15.5 9.9 0.019 14.8 9.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) DUF2070 PF09843.9 EKE40377.1 - 5.5 5.2 18.0 6.9 4.8 18.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) WD40 PF00400.32 EKE40378.1 - 1.4e-06 28.9 2.2 5e-05 24.0 0.1 3.9 4 0 0 4 4 4 1 WD domain, G-beta repeat F-box-like PF12937.7 EKE40378.1 - 0.0088 15.9 0.1 0.018 14.9 0.1 1.5 1 0 0 1 1 1 1 F-box-like BBS2_Mid PF14783.6 EKE40378.1 - 0.019 15.0 0.1 7 6.7 0.0 3.6 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Thioredoxin_2 PF13098.6 EKE40378.1 - 0.096 13.1 0.0 0.83 10.1 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin-like domain WD40 PF00400.32 EKE40379.1 - 0.01 16.7 2.4 0.36 11.8 0.3 4.1 4 0 0 4 4 4 0 WD domain, G-beta repeat Skp1 PF01466.19 EKE40380.1 - 4e-29 100.5 0.3 6.7e-29 99.7 0.3 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EKE40380.1 - 1.3e-18 66.9 0.1 3.3e-18 65.6 0.0 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain PanZ PF12568.8 EKE40380.1 - 0.027 14.2 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ BTB PF00651.31 EKE40380.1 - 0.081 13.2 0.2 0.53 10.5 0.2 2.0 1 1 0 1 1 1 0 BTB/POZ domain VPS9 PF02204.18 EKE40381.1 - 4.9e-05 23.5 0.1 0.00013 22.2 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain SIT PF15330.6 EKE40381.1 - 3.4 8.1 8.2 0.15 12.5 1.7 2.1 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT CBFD_NFYB_HMF PF00808.23 EKE40383.1 - 1.4e-13 50.9 0.1 2.2e-13 50.3 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EKE40383.1 - 0.0099 16.2 3.6 0.22 11.9 0.1 2.1 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EKE40383.1 - 0.01 15.9 0.1 0.063 13.4 0.0 1.9 1 1 1 2 2 2 0 Centromere kinetochore component CENP-T histone fold CDC4_D PF16856.5 EKE40383.1 - 0.2 11.5 1.8 29 4.6 0.0 3.5 4 0 0 4 4 4 0 Cell division control protein 4 dimerisation domain RMI1_N PF08585.12 EKE40384.1 - 2.4e-28 99.4 2.2 5.2e-22 78.7 0.4 2.0 1 1 1 2 2 2 2 RecQ mediated genome instability protein CLASP_N PF12348.8 EKE40385.1 - 2e-06 27.6 13.3 2.1e-05 24.2 1.0 4.2 4 2 1 5 5 5 2 CLASP N terminal Vac14_Fab1_bd PF12755.7 EKE40385.1 - 8.3e-06 26.3 4.8 1.1 10.0 0.0 4.9 3 1 1 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 EKE40385.1 - 2.2e-05 24.3 0.5 11 6.6 0.0 6.0 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 EKE40385.1 - 8.3e-05 22.7 23.5 0.04 14.0 3.3 5.3 4 2 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 EKE40385.1 - 0.025 14.5 10.8 0.74 9.7 2.4 4.6 3 2 0 3 3 3 0 Domain of unknown function (DUF3385) DUF4523 PF15023.6 EKE40385.1 - 0.83 9.5 6.9 0.22 11.4 0.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4523) NUC173 PF08161.12 EKE40385.1 - 1 9.0 5.4 2.7 7.6 0.1 3.7 3 2 1 4 4 4 0 NUC173 domain DUF5354 PF17305.2 EKE40386.1 - 0.03 14.5 1.9 0.2 11.9 1.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5354) Pro_isomerase PF00160.21 EKE40389.1 - 6.7e-43 146.7 0.3 7.6e-43 146.5 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SKICH PF17751.1 EKE40390.1 - 9.7e-07 29.3 0.5 0.044 14.3 0.0 2.3 2 0 0 2 2 2 2 SKICH domain ATPgrasp_ST PF14397.6 EKE40390.1 - 0.0037 16.6 0.0 0.0064 15.8 0.0 1.3 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp fn3 PF00041.21 EKE40390.1 - 0.11 12.8 1.0 0.31 11.4 0.4 1.9 2 0 0 2 2 2 0 Fibronectin type III domain KH_1 PF00013.29 EKE40391.1 - 0.00081 19.2 0.0 0.0025 17.6 0.0 1.8 1 0 0 1 1 1 1 KH domain Lyase_8_C PF02884.17 EKE40391.1 - 0.04 14.4 0.0 0.16 12.5 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide lyase family 8, C-terminal beta-sandwich domain ArfGap PF01412.18 EKE40392.1 - 3.1e-30 104.6 0.0 3.1e-30 104.6 0.0 3.0 5 0 0 5 5 5 1 Putative GTPase activating protein for Arf PH PF00169.29 EKE40392.1 - 4.5e-10 40.0 2.3 5.1e-10 39.8 0.4 2.1 2 0 0 2 2 2 1 PH domain Ank_2 PF12796.7 EKE40392.1 - 5e-07 30.2 0.1 1.4e-06 28.8 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EKE40392.1 - 9.7e-06 25.8 0.2 2.4e-05 24.5 0.2 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EKE40392.1 - 1.6e-05 25.3 0.2 5.1e-05 23.7 0.2 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EKE40392.1 - 0.0011 19.4 0.4 0.0061 17.0 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat BAR_3 PF16746.5 EKE40392.1 - 0.01 15.5 12.0 0.014 15.1 9.6 2.4 1 1 1 2 2 2 0 BAR domain of APPL family PH_11 PF15413.6 EKE40392.1 - 0.014 15.8 5.5 0.015 15.7 1.5 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain Spore_III_AB PF09548.10 EKE40392.1 - 0.082 13.0 6.5 2.1 8.4 0.6 3.3 2 1 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) Tctex-1 PF03645.13 EKE40392.1 - 0.087 13.1 0.5 0.5 10.6 0.1 2.5 2 0 0 2 2 2 0 Tctex-1 family Ank_3 PF13606.6 EKE40392.1 - 0.12 13.0 0.1 0.58 10.9 0.1 2.3 1 0 0 1 1 1 0 Ankyrin repeat PH_13 PF16652.5 EKE40392.1 - 4.9 6.9 11.4 0.19 11.6 1.6 3.4 3 2 0 3 3 3 0 Pleckstrin homology domain Peptidase_C12 PF01088.21 EKE40393.1 - 2.9e-23 82.7 0.5 3.3e-23 82.5 0.5 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 FragX_IP PF05994.11 EKE40393.1 - 0.015 13.4 0.1 0.016 13.3 0.1 1.1 1 0 0 1 1 1 0 Cytoplasmic Fragile-X interacting family UCH PF00443.29 EKE40394.1 - 5e-23 81.9 2.3 8.4e-23 81.2 2.3 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EKE40394.1 - 3.9e-08 33.5 2.8 7.1e-08 32.7 2.8 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Tmemb_14 PF03647.13 EKE40395.1 - 0.0022 18.7 1.1 0.0043 17.8 0.2 2.0 2 0 0 2 2 2 1 Transmembrane proteins 14C 7tm_1 PF00001.21 EKE40395.1 - 0.0023 17.3 1.9 0.0023 17.3 1.9 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Peptidase_M56 PF05569.11 EKE40395.1 - 0.0062 15.8 0.4 0.0062 15.8 0.4 1.9 1 1 0 2 2 2 1 BlaR1 peptidase M56 Orf78 PF06024.12 EKE40395.1 - 0.0077 16.5 0.8 0.0077 16.5 0.8 2.2 2 2 0 2 2 2 1 Orf78 (ac78) RIFIN PF02009.16 EKE40395.1 - 0.034 14.0 0.8 0.052 13.4 0.8 1.2 1 0 0 1 1 1 0 Rifin TMEM208_SND2 PF05620.11 EKE40395.1 - 0.036 13.9 0.1 0.036 13.9 0.1 3.2 4 0 0 4 4 4 0 SRP-independent targeting protein 2/TMEM208 SARAF PF06682.12 EKE40395.1 - 0.057 13.1 0.0 0.13 11.8 0.0 1.6 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Rnf-Nqr PF02508.14 EKE40395.1 - 1.6 8.7 9.7 0.27 11.2 2.7 2.1 2 0 0 2 2 2 0 Rnf-Nqr subunit, membrane protein ATG27 PF09451.10 EKE40395.1 - 9.8 5.9 8.1 11 5.7 1.2 2.3 1 1 0 2 2 2 0 Autophagy-related protein 27 TLD PF07534.16 EKE40396.1 - 3.1e-07 30.7 1.6 3.9e-07 30.4 1.6 1.2 1 0 0 1 1 1 1 TLD DNA_primase_lrg PF04104.14 EKE40397.1 - 1.8e-26 93.2 3.2 2.5e-26 92.7 3.2 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit zf-TRAF_2 PF15965.5 EKE40397.1 - 0.85 10.1 3.3 25 5.4 0.1 2.7 3 0 0 3 3 3 0 TRAF-like zinc-finger tRNA_anti-codon PF01336.25 EKE40398.1 - 3.8e-05 23.6 0.3 0.00019 21.4 0.1 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EKE40398.1 - 0.035 13.8 4.6 0.078 12.7 4.6 1.6 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 zf-C3HC4_3 PF13920.6 EKE40398.1 - 1.9 8.4 13.3 0.22 11.4 8.1 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) JMY PF15871.5 EKE40399.1 - 0.011 15.0 0.3 0.015 14.6 0.3 1.2 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein POP1 PF06978.11 EKE40400.1 - 6.8e-23 81.7 19.6 1.9e-13 50.9 0.8 3.0 2 1 1 3 3 3 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EKE40400.1 - 1.3e-14 54.3 0.3 1.3e-14 54.3 0.3 2.2 2 0 0 2 2 2 1 POPLD (NUC188) domain Inhibitor_I9 PF05922.16 EKE40400.1 - 1.2 9.8 4.1 4.4 8.0 0.0 3.3 3 0 0 3 3 3 0 Peptidase inhibitor I9 Bac_RepA_C PF18008.1 EKE40400.1 - 5.3 7.5 8.2 0.96 9.8 1.0 3.1 3 0 0 3 3 3 0 Replication initiator protein A C-terminal domain MobC PF05713.11 EKE40401.1 - 0.016 15.7 0.5 0.037 14.5 0.5 1.7 1 0 0 1 1 1 0 Bacterial mobilisation protein (MobC) LRR_5 PF13306.6 EKE40402.1 - 3.7e-69 230.6 32.1 2.1e-26 92.4 5.5 3.5 2 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE40402.1 - 2.4e-17 62.5 0.4 0.0042 16.8 0.1 5.9 3 2 2 5 5 5 4 Leucine rich repeat Mucin PF01456.17 EKE40403.1 - 0.89 9.5 6.9 1.4 8.9 0.1 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein Laminin_II PF06009.12 EKE40405.1 - 0.015 15.4 8.4 0.02 14.9 8.4 1.2 1 0 0 1 1 1 0 Laminin Domain II DUF4200 PF13863.6 EKE40405.1 - 0.019 15.4 8.4 0.028 14.8 8.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) AAA_13 PF13166.6 EKE40405.1 - 0.059 12.0 10.5 0.059 12.0 10.5 1.0 1 0 0 1 1 1 0 AAA domain Lipoprotein_20 PF13942.6 EKE40405.1 - 0.083 12.8 6.3 0.12 12.2 6.1 1.5 1 1 0 1 1 1 0 YfhG lipoprotein SPATA24 PF15175.6 EKE40405.1 - 0.3 11.0 14.7 0.53 10.2 4.3 1.9 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 Exonuc_VII_L PF02601.15 EKE40405.1 - 0.38 10.3 6.3 0.39 10.2 6.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 EKE40405.1 - 5.8 5.7 9.4 6.2 5.6 9.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein PAP_assoc PF03828.19 EKE40406.1 - 0.11 12.8 0.5 0.54 10.5 0.0 2.2 2 0 0 2 2 2 0 Cid1 family poly A polymerase PPP1R35_C PF15503.6 EKE40406.1 - 0.11 12.3 0.1 0.27 11.0 0.1 1.6 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 35 C-terminus HATPase_c_4 PF13749.6 EKE40407.1 - 0.014 15.5 0.0 0.043 14.0 0.0 1.8 1 0 0 1 1 1 0 Putative ATP-dependent DNA helicase recG C-terminal Ribonuclease_T2 PF00445.18 EKE40408.1 - 1.3e-32 113.5 1.6 1.7e-32 113.2 1.6 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family zf-C3Hc3H PF13891.6 EKE40408.1 - 0.0012 19.2 0.3 0.0042 17.4 0.3 1.9 1 0 0 1 1 1 1 Potential DNA-binding domain Alpha_kinase PF02816.18 EKE40409.1 - 3.2e-47 161.0 3.8 5.7e-47 160.2 3.8 1.4 1 0 0 1 1 1 1 Alpha-kinase family Atu4866 PF11512.8 EKE40409.1 - 0.08 13.3 0.0 0.23 11.9 0.0 1.7 1 0 0 1 1 1 0 Agrobacterium tumefaciens protein Atu4866 Vps26 PF03643.15 EKE40410.1 - 2.6e-42 144.8 0.4 3e-42 144.5 0.4 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 EKE40410.1 - 0.011 16.2 1.1 1.9 8.9 0.7 2.5 2 1 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EKE40410.1 - 0.14 12.2 0.9 3.7 7.6 0.0 2.6 3 0 0 3 3 3 0 Arrestin (or S-antigen), N-terminal domain WD40 PF00400.32 EKE40411.1 - 3e-31 107.0 13.1 4.7e-07 30.4 0.6 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE40411.1 - 9.1e-08 32.3 0.9 0.0007 19.8 0.3 3.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 EKE40411.1 - 0.00067 19.4 1.7 0.13 11.9 0.1 3.5 3 1 0 3 3 3 1 TUP1-like enhancer of split WD40_like PF17005.5 EKE40411.1 - 0.00069 19.0 0.5 0.0051 16.2 0.5 2.1 1 1 0 1 1 1 1 WD40-like domain VID27 PF08553.10 EKE40411.1 - 0.016 14.3 0.1 0.11 11.6 0.0 2.2 2 1 1 3 3 3 0 VID27 C-terminal WD40-like domain Ge1_WD40 PF16529.5 EKE40411.1 - 0.021 13.8 0.2 0.9 8.4 0.1 3.3 2 2 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Homeobox_KN PF05920.11 EKE40413.1 - 0.16 11.9 2.9 2.3 8.2 0.6 3.4 2 0 0 2 2 2 0 Homeobox KN domain Ras PF00071.22 EKE40414.1 - 4.5e-50 169.4 0.5 5.6e-50 169.1 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40414.1 - 1.7e-32 112.1 0.2 2.3e-32 111.7 0.2 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40414.1 - 3.2e-13 49.5 0.2 4e-13 49.2 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE40414.1 - 1.7e-05 24.9 0.0 2.6e-05 24.2 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE40414.1 - 9.1e-05 22.0 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE40414.1 - 0.00013 21.6 0.3 0.034 13.7 0.1 2.6 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EKE40414.1 - 0.00021 21.1 0.1 0.00053 19.7 0.1 1.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EKE40414.1 - 0.006 16.0 0.1 0.0073 15.7 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Hexapep PF00132.24 EKE40414.1 - 0.072 12.8 0.1 0.18 11.6 0.1 1.7 1 0 0 1 1 1 0 Bacterial transferase hexapeptide (six repeats) Arf PF00025.21 EKE40415.1 - 2e-24 86.0 0.0 2.8e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EKE40415.1 - 5.1e-11 42.8 0.0 1.1e-10 41.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EKE40415.1 - 1.5e-09 37.6 0.4 1.9e-09 37.3 0.4 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EKE40415.1 - 6.4e-09 35.4 1.4 2e-08 33.8 0.9 1.9 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EKE40415.1 - 1.8e-07 30.8 0.1 2.2e-07 30.4 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE40415.1 - 2.8e-05 24.2 0.0 4.8e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE40415.1 - 0.022 14.2 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 EKE40415.1 - 0.1 11.9 1.5 4.7 6.4 0.3 2.1 1 1 1 2 2 2 0 Septin Prion_bPrPp PF11587.8 EKE40415.1 - 0.3 11.0 1.9 0.44 10.4 1.0 1.7 2 0 0 2 2 2 0 Major prion protein bPrPp - N terminal XPG_I PF00867.18 EKE40417.1 - 1.6e-20 73.2 0.0 6.2e-20 71.4 0.0 2.1 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EKE40417.1 - 5.5e-16 58.9 0.4 9.9e-15 54.9 0.1 2.5 2 0 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EKE40417.1 - 4.3e-05 24.0 0.3 0.00023 21.7 0.0 2.2 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.7 EKE40417.1 - 0.00026 20.6 0.0 0.00076 19.0 0.0 1.7 2 0 0 2 2 2 1 XPG domain containing Pox_G5 PF04599.12 EKE40417.1 - 0.042 12.8 2.2 0.12 11.4 2.2 1.7 1 1 0 1 1 1 0 Poxvirus G5 protein PPTA PF01239.22 EKE40418.1 - 1.8e-27 94.2 14.8 2e-08 33.7 0.4 4.5 4 0 0 4 4 4 4 Protein prenyltransferase alpha subunit repeat DUF4508 PF14969.6 EKE40419.1 - 0.055 13.7 0.0 0.21 11.9 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) XRN1_D2_D3 PF18334.1 EKE40420.1 - 0.54 10.5 4.5 0.27 11.5 0.7 2.5 2 0 0 2 2 2 0 Exoribonuclease Xrn1 D2/D3 domain DivIC PF04977.15 EKE40422.1 - 7.7 6.4 12.3 0.93 9.3 3.7 2.5 1 1 1 2 2 2 0 Septum formation initiator Sel1 PF08238.12 EKE40423.1 - 6.2e-37 125.2 0.9 1e-10 41.9 0.0 5.4 5 0 0 5 5 5 4 Sel1 repeat TPR_2 PF07719.17 EKE40423.1 - 0.0002 21.2 2.4 4.3 7.7 0.3 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EKE40423.1 - 0.0013 18.4 1.8 12 5.9 0.2 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE40423.1 - 0.0028 17.8 2.4 0.025 14.8 0.1 3.3 2 2 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EKE40423.1 - 0.0043 17.2 2.6 8.6 6.9 0.2 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EKE40423.1 - 0.0075 16.8 0.2 22 6.0 0.0 4.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 EKE40423.1 - 0.011 16.2 0.8 3.3 8.3 0.0 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EKE40423.1 - 0.022 15.1 1.2 21 5.5 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR PF01535.20 EKE40423.1 - 0.026 14.8 1.1 36 4.9 0.0 3.8 4 0 0 4 4 4 0 PPR repeat DUF2786 PF10979.8 EKE40423.1 - 0.074 13.0 0.3 0.19 11.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2786) PPR_2 PF13041.6 EKE40423.1 - 0.085 13.1 0.2 41 4.5 0.1 3.3 3 0 0 3 3 3 0 PPR repeat family zf-RING_2 PF13639.6 EKE40424.1 - 1.7e-05 25.1 11.0 1.7e-05 25.1 11.0 3.1 3 0 0 3 3 3 1 Ring finger domain FANCL_C PF11793.8 EKE40424.1 - 6.3e-05 23.1 7.6 0.0002 21.4 6.6 2.4 2 0 0 2 2 2 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 EKE40424.1 - 0.034 14.2 4.8 0.083 12.9 4.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EKE40424.1 - 0.075 13.3 12.7 0.43 10.9 12.7 2.2 1 1 1 2 2 2 0 RING-H2 zinc finger domain C1_1 PF00130.22 EKE40424.1 - 0.85 9.6 15.0 0.031 14.2 6.1 2.8 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 EKE40424.1 - 1.2 9.6 7.8 3.1 8.2 7.8 1.8 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_2 PF13923.6 EKE40424.1 - 1.5 8.7 14.0 1.6 8.6 10.7 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 EKE40424.1 - 3.7 7.8 11.7 0.77 9.9 7.6 2.1 2 0 0 2 2 2 0 RING-variant domain Ras PF00071.22 EKE40425.1 - 8.3e-54 181.6 0.0 9.5e-54 181.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40425.1 - 7.3e-23 81.1 0.0 1e-22 80.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40425.1 - 1.1e-09 37.9 0.0 1.4e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE40425.1 - 0.0016 17.8 0.0 0.0025 17.2 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE40425.1 - 0.0099 15.4 0.2 0.017 14.6 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SF3b10 PF07189.11 EKE40426.1 - 1.4e-35 121.3 0.1 1.6e-35 121.0 0.1 1.1 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) DUF1874 PF08960.10 EKE40426.1 - 0.052 13.7 0.1 0.09 12.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1874) Peptidase_M7 PF02031.16 EKE40426.1 - 0.13 12.3 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 Streptomyces extracellular neutral proteinase (M7) family Aa_trans PF01490.18 EKE40427.1 - 5.3e-22 78.1 35.8 8.5e-22 77.4 35.8 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 EKE40427.1 - 2.3e-09 36.6 45.2 2.7e-09 36.4 42.3 2.0 2 0 0 2 2 2 1 Amino acid permease NodZ PF05830.11 EKE40427.1 - 0.065 12.0 0.0 0.12 11.1 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein Z (NodZ) WHEP-TRS PF00458.20 EKE40427.1 - 0.14 12.4 4.2 0.31 11.2 4.2 1.5 1 0 0 1 1 1 0 WHEP-TRS domain F-box PF00646.33 EKE40430.1 - 0.00013 21.7 0.0 0.00044 20.0 0.0 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EKE40430.1 - 0.0015 18.4 0.1 0.012 15.4 0.0 2.3 2 0 0 2 2 2 1 F-box-like RhoGAP PF00620.27 EKE40431.1 - 7.8e-25 87.5 0.0 1.5e-24 86.6 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Sad1_UNC PF07738.13 EKE40432.1 - 8.4e-15 55.0 0.9 8.4e-15 55.0 0.9 1.8 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal F5_F8_type_C PF00754.25 EKE40432.1 - 0.00019 21.6 0.0 0.00039 20.5 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain Syntaxin_2 PF14523.6 EKE40432.1 - 0.25 11.7 16.4 0.046 14.1 10.4 2.7 3 0 0 3 3 3 0 Syntaxin-like protein RasGAP PF00616.19 EKE40433.1 - 1.7e-06 27.9 9.7 0.043 13.5 2.8 3.2 2 1 1 3 3 3 3 GTPase-activator protein for Ras-like GTPase UBA PF00627.31 EKE40434.1 - 6.1e-06 26.0 0.1 9.7e-06 25.4 0.1 1.3 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.6 EKE40434.1 - 0.00014 21.6 0.5 0.00037 20.2 0.5 1.7 1 0 0 1 1 1 1 UBA-like domain DUF1751 PF08551.10 EKE40434.1 - 0.00031 21.2 5.0 0.00031 21.2 5.0 2.3 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) AI-2E_transport PF01594.16 EKE40434.1 - 0.00036 19.8 0.2 0.00036 19.8 0.2 2.7 1 1 2 3 3 3 1 AI-2E family transporter HOIP-UBA PF16678.5 EKE40434.1 - 0.0028 17.7 0.0 0.0042 17.1 0.0 1.2 1 0 0 1 1 1 1 HOIP UBA domain pair Rhomboid PF01694.22 EKE40434.1 - 2.3 8.2 9.5 9.1 6.3 9.5 2.1 1 1 0 1 1 1 0 Rhomboid family SRF-TF PF00319.18 EKE40435.1 - 4.6e-22 77.3 0.5 7.8e-22 76.5 0.5 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Vps35 PF03635.17 EKE40436.1 - 2.6e-39 135.4 22.7 1.9e-38 132.5 22.7 2.3 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 RRF PF01765.19 EKE40436.1 - 0.059 13.3 0.1 0.2 11.6 0.0 1.9 1 1 0 1 1 1 0 Ribosome recycling factor Man-6-P_recep PF02157.15 EKE40437.1 - 1.5e-14 53.7 5.7 8.4e-13 48.0 0.1 2.2 2 0 0 2 2 2 2 Mannose-6-phosphate receptor ATG27 PF09451.10 EKE40437.1 - 2.8e-11 43.8 1.7 4.2e-11 43.2 1.1 1.4 1 1 0 2 2 2 1 Autophagy-related protein 27 CENP-B_dimeris PF09026.10 EKE40437.1 - 0.0005 20.4 0.2 0.00092 19.6 0.2 1.5 1 0 0 1 1 1 1 Centromere protein B dimerisation domain Spin-Ssty PF02513.17 EKE40437.1 - 0.06 13.1 0.4 0.16 11.7 0.4 1.6 1 0 0 1 1 1 0 Spin/Ssty Family Cwf_Cwc_15 PF04889.12 EKE40437.1 - 0.64 9.7 5.5 0.78 9.4 5.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein WD40 PF00400.32 EKE40438.1 - 2.3e-06 28.2 0.6 1.5e-05 25.6 0.2 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE40438.1 - 8.8e-05 22.7 0.0 0.024 14.9 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.22 EKE40439.1 - 9e-06 25.4 0.1 1.7e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PI3_PI4_kinase PF00454.27 EKE40440.1 - 1.6e-42 146.0 0.1 1.4e-29 103.7 0.0 2.4 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EKE40440.1 - 2e-33 115.4 0.2 3.7e-33 114.5 0.2 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 EKE40440.1 - 1.8e-13 50.6 0.0 3.8e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 NAM-associated PF14303.6 EKE40442.1 - 0.018 15.7 0.1 0.027 15.2 0.1 1.4 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain DNA_processg_A PF02481.15 EKE40442.1 - 0.1 11.8 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 DNA recombination-mediator protein A LRR_4 PF12799.7 EKE40444.1 - 5.2e-07 29.9 7.3 0.00026 21.3 0.8 4.6 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) ENTH PF01417.20 EKE40444.1 - 0.00018 21.5 0.3 0.00085 19.4 0.1 2.2 2 0 0 2 2 2 1 ENTH domain WD40 PF00400.32 EKE40444.1 - 0.0071 17.2 0.1 0.45 11.5 0.1 3.5 3 1 1 4 4 4 1 WD domain, G-beta repeat Recep_L_domain PF01030.24 EKE40444.1 - 0.021 14.9 0.1 1.8 8.7 0.0 3.0 2 0 0 2 2 2 0 Receptor L domain LRR_8 PF13855.6 EKE40444.1 - 0.84 9.4 5.8 6.3 6.6 1.5 3.7 1 1 2 3 3 3 0 Leucine rich repeat PhoLip_ATPase_C PF16212.5 EKE40446.1 - 8.8e-58 196.0 26.8 8.8e-58 196.0 26.8 2.6 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EKE40446.1 - 1.1e-22 79.5 5.3 1.1e-22 79.5 5.3 2.7 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EKE40446.1 - 3.1e-11 43.2 0.1 3.1e-10 40.0 0.0 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EKE40446.1 - 5e-11 43.3 5.3 5.6e-06 26.8 0.6 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EKE40446.1 - 6.9e-10 38.7 0.0 6.9e-10 38.7 0.0 3.1 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EKE40446.1 - 0.03 14.1 0.2 0.03 14.1 0.2 3.0 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase SlyX PF04102.12 EKE40447.1 - 0.0069 17.0 3.7 0.0069 17.0 3.7 5.5 3 1 2 5 5 5 1 SlyX DUF4200 PF13863.6 EKE40447.1 - 0.0078 16.6 11.5 0.0078 16.6 11.5 4.9 2 1 2 4 4 4 2 Domain of unknown function (DUF4200) Fis1_TPR_C PF14853.6 EKE40447.1 - 0.24 11.5 8.4 1.8 8.7 0.3 3.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Atg14 PF10186.9 EKE40447.1 - 1.8 7.5 56.1 0.57 9.2 25.6 3.4 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 HMMR_N PF15905.5 EKE40447.1 - 4.6 6.6 86.2 0.017 14.6 38.4 3.5 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor N-terminal EF-hand_6 PF13405.6 EKE40448.1 - 5.3e-21 72.7 3.8 0.0021 17.8 0.0 6.3 6 0 0 6 6 6 5 EF-hand domain EF-hand_1 PF00036.32 EKE40448.1 - 6.8e-19 66.0 3.5 0.0046 16.4 0.0 6.3 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.6 EKE40448.1 - 1.3e-15 57.6 3.0 0.0011 19.3 0.1 4.7 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EKE40448.1 - 1.6e-10 40.0 0.4 0.12 12.0 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EKE40448.1 - 3.4e-06 26.8 5.0 1.3 8.9 0.0 5.0 5 0 0 5 5 5 3 EF-hand domain pair EF-hand_10 PF14788.6 EKE40448.1 - 9.5e-06 25.4 1.8 0.45 10.4 0.3 4.2 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 EKE40448.1 - 5.5e-05 23.5 2.4 0.0046 17.3 0.4 3.3 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EKE40448.1 - 0.1 12.5 0.5 13 5.8 0.2 3.1 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Histone PF00125.24 EKE40449.1 - 2.2e-18 66.9 2.2 3.3e-18 66.3 2.2 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 FG-GAP_2 PF14312.6 EKE40450.1 - 3.5e-07 30.4 3.5 0.062 13.6 0.0 4.4 4 0 0 4 4 4 3 FG-GAP repeat VHS PF00790.19 EKE40451.1 - 3.2e-05 23.8 1.4 6.9e-05 22.7 0.4 2.0 1 1 0 2 2 2 1 VHS domain DUF1829 PF08862.10 EKE40451.1 - 0.064 13.7 0.5 0.34 11.4 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF1829 bZIP_2 PF07716.15 EKE40453.1 - 1.3e-06 28.4 6.1 1.3e-06 28.4 6.1 1.9 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 EKE40453.1 - 0.00039 20.4 11.8 0.00039 20.4 11.8 2.5 2 1 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 EKE40453.1 - 0.005 17.3 8.7 0.005 17.3 8.7 1.7 2 1 0 2 2 2 1 bZIP Maf transcription factor FapA PF03961.13 EKE40453.1 - 0.66 8.5 9.5 0.72 8.4 9.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A SatD PF16264.5 EKE40455.1 - 0.035 13.7 0.2 6.1 6.4 0.0 2.6 2 1 0 2 2 2 0 SatD family (SatD) DHHC PF01529.20 EKE40456.1 - 1.4e-31 109.3 7.8 1.4e-31 109.3 7.8 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2207 PF09972.9 EKE40456.1 - 0.028 13.2 4.0 0.25 10.0 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Synaptobrevin PF00957.21 EKE40457.1 - 4.1e-13 48.9 1.3 9.6e-13 47.7 1.3 1.6 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EKE40457.1 - 1.5e-06 28.1 0.1 2.5e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain COG2 PF06148.11 EKE40457.1 - 0.01 15.9 0.6 0.088 12.9 0.2 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RRM_1 PF00076.22 EKE40458.1 - 7.3e-21 73.8 0.1 1.3e-12 47.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Surp PF01805.20 EKE40458.1 - 9.6e-11 41.5 0.4 2e-10 40.5 0.4 1.6 1 0 0 1 1 1 1 Surp module RRM_5 PF13893.6 EKE40458.1 - 5e-07 29.4 0.0 0.00033 20.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE40458.1 - 5.5e-06 26.3 0.1 0.001 19.0 0.0 2.8 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EKE40458.1 - 0.0002 21.2 0.1 0.71 9.8 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_3 PF08777.11 EKE40458.1 - 0.00032 20.7 3.3 0.42 10.7 0.2 3.2 2 1 1 3 3 3 2 RNA binding motif DUF5319 PF17252.2 EKE40458.1 - 0.024 14.9 3.7 0.34 11.2 1.1 2.9 2 1 0 2 2 2 0 Family of unknown function (DUF5319) LSM PF01423.22 EKE40459.1 - 8.6e-17 60.6 3.0 1.1e-16 60.2 3.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EKE40459.1 - 0.0018 18.4 0.1 0.0027 17.8 0.1 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 EKE40459.1 - 0.019 14.6 0.1 0.032 13.9 0.1 1.4 1 0 0 1 1 1 0 Hfq protein BPL_C PF02237.17 EKE40459.1 - 0.17 11.8 0.2 0.32 10.9 0.2 1.4 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain His_Phos_2 PF00328.22 EKE40460.1 - 4.5e-27 95.4 4.4 6.2e-27 94.9 4.4 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) SRP54 PF00448.22 EKE40461.1 - 1.3e-77 259.9 1.2 2.7e-77 258.9 0.9 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EKE40461.1 - 1.5e-23 83.3 1.0 1.5e-23 83.3 1.0 3.1 3 1 1 4 4 3 1 Signal peptide binding domain SRP54_N PF02881.19 EKE40461.1 - 5e-14 52.3 1.8 1.9e-13 50.5 1.8 2.1 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 EKE40461.1 - 5.7e-08 32.5 0.1 2e-07 30.8 0.1 1.9 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EKE40461.1 - 6.6e-05 22.0 0.1 0.00029 19.9 0.1 2.0 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_17 PF13207.6 EKE40461.1 - 7.4e-05 23.2 0.4 0.00058 20.3 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EKE40461.1 - 9.3e-05 22.6 0.0 0.0003 21.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EKE40461.1 - 0.00031 20.8 0.4 0.0017 18.4 0.1 2.4 2 1 0 2 2 1 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EKE40461.1 - 0.00077 18.8 0.2 0.002 17.4 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin CbiA PF01656.23 EKE40461.1 - 0.0012 18.9 0.0 0.0046 17.0 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 EKE40461.1 - 0.0024 17.8 0.1 0.0089 15.9 0.1 2.1 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B SRPRB PF09439.10 EKE40461.1 - 0.004 16.6 1.5 1.3 8.5 0.1 3.2 4 0 0 4 4 4 1 Signal recognition particle receptor beta subunit AAA_30 PF13604.6 EKE40461.1 - 0.0057 16.4 0.1 0.018 14.7 0.1 1.9 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.18 EKE40461.1 - 0.008 15.5 0.0 0.018 14.4 0.0 1.6 1 0 0 1 1 1 1 6-phosphofructo-2-kinase APS_kinase PF01583.20 EKE40461.1 - 0.0081 16.1 0.0 0.02 14.8 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase CLP1_P PF16575.5 EKE40461.1 - 0.027 14.2 0.1 5.8 6.7 0.0 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ResIII PF04851.15 EKE40461.1 - 0.028 14.4 0.9 0.094 12.7 0.9 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Thymidylate_kin PF02223.17 EKE40461.1 - 0.029 14.1 1.7 0.23 11.1 0.1 2.7 3 0 0 3 3 2 0 Thymidylate kinase Arf PF00025.21 EKE40461.1 - 0.039 13.4 0.1 0.13 11.7 0.1 1.8 1 0 0 1 1 1 0 ADP-ribosylation factor family ATP_bind_1 PF03029.17 EKE40461.1 - 0.057 13.2 0.5 0.16 11.8 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EKE40461.1 - 0.058 13.7 0.1 0.49 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF373 PF04123.13 EKE40461.1 - 0.062 12.7 0.1 0.1 12.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) G-alpha PF00503.20 EKE40461.1 - 0.072 12.2 0.8 0.27 10.3 0.0 2.3 2 1 1 3 3 3 0 G-protein alpha subunit AAA_28 PF13521.6 EKE40461.1 - 0.083 13.1 0.2 0.21 11.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA PF00004.29 EKE40461.1 - 0.12 12.8 4.8 0.6 10.5 0.5 3.6 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) DUF2209 PF09974.9 EKE40461.1 - 0.13 12.6 0.0 0.33 11.3 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) DS PF01916.17 EKE40463.1 - 1e-98 330.2 0.3 1.1e-98 330.0 0.3 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase HEAT PF02985.22 EKE40464.1 - 0.00025 21.1 0.0 49 4.6 0.0 6.1 7 0 0 7 7 7 0 HEAT repeat Importin_rep_4 PF18808.1 EKE40464.1 - 0.00038 20.7 1.1 0.017 15.4 0.3 3.2 2 0 0 2 2 2 1 Importin repeat NopRA1 PF16201.5 EKE40464.1 - 0.025 14.1 7.7 0.1 12.2 0.4 4.1 3 1 0 3 3 3 0 Nucleolar pre-ribosomal-associated protein 1 Arm PF00514.23 EKE40464.1 - 0.12 12.5 1.0 26 5.1 0.0 4.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EKE40464.1 - 0.16 12.0 22.7 0.25 11.4 0.3 5.5 3 3 3 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EKE40464.1 - 0.35 11.5 20.8 1.2 9.7 0.3 7.3 7 2 0 7 7 7 0 Vacuolar 14 Fab1-binding region RhoGEF PF00621.20 EKE40465.1 - 3.6e-08 33.9 3.7 3.6e-08 33.9 3.7 3.3 3 1 1 4 4 4 2 RhoGEF domain SUIM_assoc PF16619.5 EKE40465.1 - 0.15 12.1 1.4 0.19 11.8 0.1 1.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-MIZ PF02891.20 EKE40466.1 - 3.2e-18 65.2 3.9 6.5e-18 64.2 3.9 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EKE40466.1 - 7e-06 25.8 3.3 1.8e-05 24.4 3.3 1.8 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-P11 PF03854.14 EKE40466.1 - 0.047 13.3 1.5 0.16 11.6 1.5 1.9 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_UBOX PF13445.6 EKE40466.1 - 0.073 13.1 5.9 0.52 10.4 0.3 2.6 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_5 PF14634.6 EKE40466.1 - 0.58 10.2 4.0 1.4 8.9 4.0 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C2H2_aberr PF17017.5 EKE40466.1 - 1 9.5 6.4 0.83 9.8 1.3 2.6 3 0 0 3 3 3 0 Aberrant zinc-finger zf-RING_2 PF13639.6 EKE40466.1 - 1.1 9.7 4.4 4.2 7.8 4.6 2.0 1 1 0 1 1 1 0 Ring finger domain MFAP1 PF06991.11 EKE40467.1 - 1.7e-40 139.2 23.9 2.2e-40 138.8 23.9 1.1 1 0 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing DUF2852 PF11014.8 EKE40467.1 - 0.025 14.7 3.9 0.025 14.7 3.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) DUF1198 PF06711.11 EKE40468.1 - 4.8 7.2 6.0 1.2 9.2 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1198) Peptidase_M49 PF03571.15 EKE40469.1 - 3.6e-178 593.4 0.1 4.4e-178 593.1 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M49 CitMHS PF03600.16 EKE40470.1 - 2.5e-22 79.4 9.8 2.5e-22 79.4 9.8 2.3 1 1 1 2 2 2 2 Citrate transporter TrkA_C PF02080.21 EKE40470.1 - 0.0008 19.2 0.0 0.0051 16.6 0.0 2.2 2 0 0 2 2 2 1 TrkA-C domain RabGAP-TBC PF00566.18 EKE40472.1 - 1.8e-22 80.1 9.4 3.2e-22 79.3 9.4 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain YidC_periplas PF14849.6 EKE40473.1 - 0.041 13.8 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 YidC periplasmic domain Acetyltransf_2 PF00797.17 EKE40473.1 - 0.093 12.5 1.4 10 5.8 0.1 2.8 2 1 1 3 3 3 0 N-acetyltransferase Thioredoxin PF00085.20 EKE40474.1 - 1.6e-14 53.7 0.1 1.8e-14 53.5 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EKE40474.1 - 3.1e-06 27.6 0.2 5.7e-06 26.7 0.2 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 EKE40474.1 - 6.6e-05 22.9 0.0 9.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_4 PF13462.6 EKE40474.1 - 0.00086 19.5 2.2 0.23 11.6 0.4 2.2 1 1 1 2 2 2 2 Thioredoxin PhnA_Zn_Ribbon PF08274.12 EKE40474.1 - 0.0052 16.7 0.9 0.008 16.1 0.9 1.2 1 0 0 1 1 1 1 PhnA Zinc-Ribbon OST3_OST6 PF04756.13 EKE40474.1 - 0.016 14.5 0.2 0.017 14.5 0.2 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family DUF836 PF05768.14 EKE40474.1 - 0.029 14.8 0.0 0.037 14.4 0.0 1.2 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) AhpC-TSA PF00578.21 EKE40474.1 - 0.039 13.9 0.1 0.039 13.9 0.1 1.2 1 1 0 1 1 1 0 AhpC/TSA family DUF2847 PF11009.8 EKE40474.1 - 0.055 13.4 0.1 0.075 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) Glutaredoxin PF00462.24 EKE40474.1 - 0.057 13.6 0.1 0.11 12.7 0.1 1.5 1 1 0 1 1 1 0 Glutaredoxin Thioredoxin_9 PF14595.6 EKE40474.1 - 0.073 12.8 0.0 0.092 12.5 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_8 PF13905.6 EKE40474.1 - 0.1 12.9 0.2 0.26 11.7 0.2 1.7 1 1 0 1 1 1 0 Thioredoxin-like DUF953 PF06110.11 EKE40474.1 - 0.13 11.9 0.0 0.19 11.4 0.0 1.5 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) ATP-synt_C PF00137.21 EKE40475.1 - 1.2e-21 76.8 27.8 1.3e-13 51.1 12.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Oxidored_q2 PF00420.24 EKE40475.1 - 0.16 11.6 5.2 0.16 11.6 2.1 2.5 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L G0-G1_switch_2 PF15103.6 EKE40475.1 - 6.8 7.2 5.2 2.9 8.4 2.3 1.8 2 0 0 2 2 2 0 G0/G1 switch protein 2 BLOC1_2 PF10046.9 EKE40476.1 - 0.0028 17.9 9.5 0.0028 17.9 9.5 2.6 1 1 2 3 3 3 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lebercilin PF15619.6 EKE40476.1 - 0.019 14.6 31.0 0.034 13.8 13.7 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease PRKG1_interact PF15898.5 EKE40476.1 - 0.03 15.2 28.4 0.13 13.2 7.1 2.8 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Exonuc_VII_L PF02601.15 EKE40476.1 - 0.073 12.6 15.7 0.1 12.2 15.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit HBM PF16591.5 EKE40476.1 - 0.078 12.4 11.8 0.21 11.0 11.8 1.7 1 1 0 1 1 1 0 Helical bimodular sensor domain Taxilin PF09728.9 EKE40476.1 - 0.15 11.2 37.4 0.28 10.3 35.8 1.9 1 1 0 1 1 1 0 Myosin-like coiled-coil protein CENP-F_leu_zip PF10473.9 EKE40476.1 - 0.19 11.7 35.1 1.3 9.0 17.9 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BRE1 PF08647.11 EKE40476.1 - 0.2 11.8 37.0 0.35 11.0 16.4 2.9 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Tropomyosin_1 PF12718.7 EKE40476.1 - 0.2 11.8 33.4 0.13 12.4 27.5 2.0 1 1 1 2 2 2 0 Tropomyosin like FlaC_arch PF05377.11 EKE40476.1 - 0.31 11.5 23.2 0.7 10.3 4.6 4.5 2 2 1 4 4 4 0 Flagella accessory protein C (FlaC) GIT1_C PF12205.8 EKE40476.1 - 0.32 11.1 12.3 0.18 11.9 2.9 2.5 1 1 1 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term LMBR1 PF04791.16 EKE40476.1 - 0.32 9.8 14.7 0.39 9.6 14.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF724 PF05266.14 EKE40476.1 - 0.43 10.4 22.0 0.6 9.9 22.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Filament PF00038.21 EKE40476.1 - 0.52 9.8 29.3 1.3 8.6 9.3 2.3 1 1 1 2 2 2 0 Intermediate filament protein DUF4407 PF14362.6 EKE40476.1 - 0.68 9.2 18.3 1.5 8.1 18.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) MscS_porin PF12795.7 EKE40476.1 - 0.85 9.1 24.9 9.3 5.7 24.9 2.1 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain APG6_N PF17675.1 EKE40476.1 - 1.2 9.7 36.2 1.8 9.1 24.8 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region SHE3 PF17078.5 EKE40476.1 - 1.6 8.4 30.2 3.2 7.4 15.0 2.3 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 TPR_MLP1_2 PF07926.12 EKE40476.1 - 2 8.5 31.3 1.1 9.3 25.2 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein HAUS6_N PF14661.6 EKE40476.1 - 2.5 7.6 24.9 1.3 8.6 8.8 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Spc7 PF08317.11 EKE40476.1 - 4.2 6.1 32.9 3.2 6.6 23.4 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein IFT57 PF10498.9 EKE40476.1 - 5.2 5.9 28.8 0.24 10.3 14.8 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 EKE40476.1 - 5.4 7.1 20.8 3.4 7.7 9.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) SYCE1 PF15233.6 EKE40476.1 - 5.8 7.0 32.6 0.82 9.7 6.0 2.6 1 1 2 3 3 3 0 Synaptonemal complex central element protein 1 SseC PF04888.12 EKE40476.1 - 6.7 6.2 14.7 0.83 9.2 1.0 2.3 1 1 0 2 2 2 0 Secretion system effector C (SseC) like family DUF4140 PF13600.6 EKE40476.1 - 7.3 7.1 21.1 1.8e+04 -5.4 21.1 3.6 1 1 0 1 1 0 0 N-terminal domain of unknown function (DUF4140) Tho2 PF11262.8 EKE40476.1 - 7.9 5.6 23.1 2.5 7.2 11.5 2.1 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 ADIP PF11559.8 EKE40476.1 - 8.2 6.5 34.0 5.5 7.1 20.1 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Fib_alpha PF08702.10 EKE40476.1 - 8.3 6.6 26.6 11 6.2 2.0 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 EKE40476.1 - 9.5 5.4 25.3 1.4 8.2 11.1 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DENN PF02141.21 EKE40477.1 - 7.6e-19 68.4 14.3 1.4e-17 64.3 8.6 3.3 2 1 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 EKE40477.1 - 1.3e-06 29.0 0.1 1.3e-06 29.0 0.1 3.0 3 0 0 3 3 3 1 uDENN domain DUF966 PF06136.13 EKE40477.1 - 1.6 8.3 8.7 2.7 7.6 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) FtsH_ext PF06480.15 EKE40477.1 - 2.2 8.6 6.1 3.1 8.2 2.6 3.0 2 1 0 2 2 2 0 FtsH Extracellular DUF4187 PF13821.6 EKE40478.1 - 5.8e-05 22.8 1.5 5.8e-05 22.8 1.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) zf-C2H2_2 PF12756.7 EKE40478.1 - 0.00019 21.7 3.1 0.0053 17.1 0.6 2.4 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EKE40478.1 - 0.021 15.6 8.8 1.1 10.3 3.9 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EKE40478.1 - 0.16 12.0 6.0 3.1 7.9 1.9 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EKE40478.1 - 0.52 10.1 3.3 3.3 7.6 0.2 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type DUF4679 PF15728.5 EKE40478.1 - 5.3 6.0 6.2 7.4 5.5 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) FAM76 PF16046.5 EKE40479.1 - 1 8.7 6.3 1.4 8.2 6.3 1.2 1 0 0 1 1 1 0 FAM76 protein FtsJ PF01728.19 EKE40480.1 - 1.6e-53 181.4 0.0 3e-53 180.5 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Spb1_C PF07780.12 EKE40480.1 - 2.5e-35 122.0 22.5 2.5e-35 122.0 22.5 3.5 2 2 0 3 3 3 1 Spb1 C-terminal domain DUF3381 PF11861.8 EKE40480.1 - 1.1e-21 77.3 21.8 1.1e-21 77.3 21.8 5.9 4 1 0 4 4 4 1 Domain of unknown function (DUF3381) PP2C PF00481.21 EKE40481.1 - 5.9e-35 121.1 0.0 7.6e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE40481.1 - 4.8e-05 23.1 0.0 8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE40481.1 - 0.0038 17.2 0.1 0.02 14.8 0.1 2.0 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) TatD_DNase PF01026.21 EKE40484.1 - 7.5e-40 136.9 0.0 8.8e-40 136.7 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Tau95_N PF17682.1 EKE40485.1 - 1.9e-05 24.8 0.1 0.00049 20.3 0.0 2.5 2 1 1 3 3 3 2 Tau95 Triple barrel domain LRR_5 PF13306.6 EKE40486.1 - 1e-154 507.2 94.0 7e-38 129.5 7.6 5.3 1 1 5 6 6 6 6 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE40486.1 - 7.3e-29 99.3 3.5 0.0022 17.7 0.0 10.0 3 2 9 12 12 12 9 Leucine rich repeat TcpE PF12648.7 EKE40486.1 - 0.068 13.7 1.3 4.5 7.9 0.0 3.6 4 0 0 4 4 4 0 TcpE family DUF1375 PF07119.12 EKE40486.1 - 2.9 8.4 3.9 25 5.3 0.0 4.0 5 0 0 5 5 5 0 Protein of unknown function (DUF1375) Sec7 PF01369.20 EKE40488.1 - 9.5e-29 100.4 9.5 9.5e-29 100.4 9.5 4.0 5 0 0 5 5 5 1 Sec7 domain Sec7_N PF12783.7 EKE40488.1 - 7.8e-07 29.1 3.8 7.8e-07 29.1 3.8 4.9 5 1 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal YtzH PF14165.6 EKE40488.1 - 2.2 8.8 12.9 3.3 8.2 0.0 4.7 5 0 0 5 5 5 0 YtzH-like protein Methyltr_RsmB-F PF01189.17 EKE40489.1 - 1.7e-39 135.6 0.0 6.8e-39 133.6 0.0 1.9 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EKE40489.1 - 0.00018 21.7 0.0 0.00032 20.9 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase SNF2_N PF00176.23 EKE40490.1 - 9.5e-56 189.0 0.0 2.4e-55 187.7 0.0 1.6 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE40490.1 - 5.1e-16 59.0 0.0 1.5e-15 57.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE40490.1 - 6.9e-13 49.0 0.0 2.2e-11 44.1 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EKE40490.1 - 0.00028 20.2 0.0 0.0019 17.4 0.0 2.2 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 EKE40490.1 - 0.001 18.4 0.0 0.0025 17.1 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_34 PF13872.6 EKE40490.1 - 0.064 12.1 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Rad54_N PF08658.10 EKE40490.1 - 0.065 13.4 0.2 0.26 11.4 0.1 2.1 1 1 0 1 1 1 0 Rad54 N terminal TLD PF07534.16 EKE40491.1 - 0.0002 21.6 0.3 0.00043 20.5 0.4 1.7 1 1 1 2 2 2 1 TLD DEAD PF00270.29 EKE40492.1 - 1.8e-49 167.9 0.4 3.8e-48 163.6 0.0 2.9 2 1 2 4 4 4 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE40492.1 - 1.3e-27 96.4 0.3 1.3e-27 96.4 0.3 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain CREPT PF16566.5 EKE40492.1 - 8.9 6.5 14.6 0.78 9.9 1.8 2.6 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Fcf1 PF04900.12 EKE40493.1 - 4.2e-34 116.9 1.3 4.2e-34 116.9 1.3 1.4 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 EKE40493.1 - 2.3e-11 44.0 0.0 3.3e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 PIN like domain GCV_T PF01571.21 EKE40493.1 - 0.16 11.3 0.0 0.23 10.8 0.0 1.1 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain RhoGAP PF00620.27 EKE40494.1 - 2.5e-30 105.3 0.0 7.1e-30 103.8 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain WD40 PF00400.32 EKE40495.1 - 9e-25 86.5 13.6 7.3e-07 29.8 0.1 7.1 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE40495.1 - 1.8e-11 44.2 0.2 0.00081 19.6 0.0 5.4 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EKE40495.1 - 0.00059 18.9 0.1 0.22 10.5 0.0 3.7 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DPBB_1 PF03330.18 EKE40496.1 - 8.4e-05 22.8 0.9 0.0055 17.0 0.1 3.4 2 1 0 2 2 2 1 Lytic transglycolase PP2C PF00481.21 EKE40497.1 - 3.7e-64 216.8 0.0 8.6e-64 215.6 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE40497.1 - 6.1e-06 26.0 0.0 1.4e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE40497.1 - 0.0034 17.3 0.0 0.37 10.7 0.0 2.1 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Lactamase_B PF00753.27 EKE40499.1 - 1.9e-20 73.7 0.2 3.1e-20 73.0 0.2 1.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EKE40499.1 - 2.9e-05 23.7 0.1 3.7e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TAF4 PF05236.14 EKE40500.1 - 7.9e-07 29.1 6.5 7.9e-07 29.1 6.5 2.1 2 1 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family VPS13_C PF16909.5 EKE40501.1 - 7.9e-48 162.6 11.6 5e-43 146.9 2.5 3.0 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EKE40501.1 - 2.6e-20 72.7 1.1 2.6e-20 72.7 1.1 4.1 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EKE40501.1 - 9.4e-13 48.5 16.6 1e-12 48.4 4.4 4.8 4 1 0 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 EKE40501.1 - 8.2e-09 35.2 2.0 4.9e-08 32.7 0.1 3.1 2 0 0 2 2 2 1 Repeating coiled region of VPS13 ATG_C PF09333.11 EKE40501.1 - 1e-05 25.8 0.1 6.4e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF669 PF05037.13 EKE40501.1 - 0.23 11.6 7.5 0.32 11.1 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF669) KTI12 PF08433.10 EKE40502.1 - 6.6e-70 235.7 0.2 7.4e-70 235.5 0.2 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EKE40502.1 - 4.5e-08 33.4 0.0 8.5e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EKE40502.1 - 1e-06 29.3 0.0 1.6e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EKE40502.1 - 0.0027 18.1 0.0 0.0041 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EKE40502.1 - 0.0029 17.6 0.0 0.0047 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.18 EKE40502.1 - 0.0031 16.9 0.3 0.033 13.5 0.3 2.0 1 1 0 1 1 1 1 6-phosphofructo-2-kinase T2SSE PF00437.20 EKE40502.1 - 0.0043 16.2 0.0 0.015 14.4 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein Endotoxin_C PF03944.14 EKE40502.1 - 0.0073 16.6 0.6 0.42 11.0 0.1 2.3 2 0 0 2 2 2 1 delta endotoxin AAA_28 PF13521.6 EKE40502.1 - 0.012 15.9 0.0 0.021 15.0 0.0 1.5 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.6 EKE40502.1 - 0.027 14.9 0.0 0.064 13.6 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 EKE40502.1 - 0.028 14.5 0.1 0.13 12.3 0.0 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_24 PF13479.6 EKE40502.1 - 0.052 13.3 0.0 0.082 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EKE40502.1 - 0.058 13.8 0.0 0.18 12.2 0.0 1.9 1 1 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EKE40502.1 - 0.061 12.5 0.0 0.092 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Transposase_22 PF02994.14 EKE40502.1 - 0.062 13.5 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 L1 transposable element RBD-like domain APS_kinase PF01583.20 EKE40502.1 - 0.074 12.9 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA PF00004.29 EKE40502.1 - 0.12 12.7 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TFIIE_alpha PF02002.17 EKE40503.1 - 0.045 13.6 6.2 0.044 13.6 3.9 2.2 1 1 1 2 2 2 0 TFIIE alpha subunit HGD-D PF06050.13 EKE40503.1 - 0.075 12.8 2.0 0.11 12.3 1.2 1.5 1 1 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Peptidase_S41 PF03572.18 EKE40505.1 - 2.3e-05 24.0 0.0 6.2e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Peptidase family S41 Mid2 PF04478.12 EKE40505.1 - 0.0021 17.9 2.6 0.0054 16.6 2.6 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Tweety PF04906.13 EKE40505.1 - 0.039 12.6 0.0 0.076 11.7 0.0 1.4 1 0 0 1 1 1 0 Tweety DUF5326 PF17260.2 EKE40505.1 - 0.81 9.9 4.4 1.7 8.8 4.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5326) Insulin_TMD PF17870.1 EKE40505.1 - 1.8 8.7 5.9 4.4 7.4 5.9 1.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment RhoGAP PF00620.27 EKE40506.1 - 4.9e-21 75.1 0.4 4.9e-21 75.1 0.4 2.4 3 0 0 3 3 3 1 RhoGAP domain PHD PF00628.29 EKE40506.1 - 0.014 15.3 6.6 0.041 13.8 6.6 1.8 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 EKE40506.1 - 0.018 15.1 5.5 0.055 13.6 5.5 1.9 1 0 0 1 1 1 0 KIAA1045 RING finger ANAPC4_WD40 PF12894.7 EKE40506.1 - 0.018 15.3 1.1 5.8 7.3 0.0 4.2 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain C1_1 PF00130.22 EKE40506.1 - 0.03 14.2 12.7 0.076 12.9 12.7 1.7 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PQQ PF01011.21 EKE40506.1 - 0.068 13.1 0.1 14 5.8 0.1 2.9 2 0 0 2 2 2 0 PQQ enzyme repeat C1_2 PF03107.16 EKE40506.1 - 0.09 13.1 7.3 0.3 11.4 7.3 1.9 1 0 0 1 1 1 0 C1 domain Prok-RING_1 PF14446.6 EKE40506.1 - 0.53 10.3 6.9 1.3 9.0 6.9 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 C1_2 PF03107.16 EKE40507.1 - 0.012 15.9 2.4 0.03 14.6 2.4 1.7 1 0 0 1 1 1 0 C1 domain C1_1 PF00130.22 EKE40507.1 - 0.79 9.7 9.5 0.13 12.2 5.2 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF5432 PF17497.2 EKE40507.1 - 2 8.6 11.0 2.5 8.3 0.4 4.4 4 0 0 4 4 4 0 Family of unknown function (DUF5432) TAP_C PF03943.13 EKE40508.1 - 0.083 12.5 2.9 7.6 6.3 0.1 2.8 1 1 1 2 2 2 0 TAP C-terminal domain HSP70 PF00012.20 EKE40509.1 - 8.4e-69 232.3 9.5 1.1e-68 232.0 9.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE40509.1 - 2.1e-08 33.4 0.2 1.3e-07 30.8 0.2 2.1 1 1 0 1 1 1 1 MreB/Mbl protein StbA PF06406.11 EKE40509.1 - 0.0018 17.6 1.0 0.024 13.9 0.1 2.6 1 1 0 2 2 2 1 StbA protein Dpoe2NT PF12213.8 EKE40509.1 - 0.0069 16.7 0.7 1.1 9.6 0.4 3.2 3 0 0 3 3 3 1 DNA polymerases epsilon N terminal BcrAD_BadFG PF01869.20 EKE40509.1 - 0.079 12.4 0.4 0.31 10.5 0.0 2.1 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family HSF_DNA-bind PF00447.17 EKE40510.1 - 2.3e-20 73.0 2.8 2.3e-20 73.0 2.8 1.8 2 0 0 2 2 2 1 HSF-type DNA-binding Nup54 PF13874.6 EKE40510.1 - 0.00042 20.4 3.6 0.0008 19.5 3.6 1.4 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 DUF4726 PF15855.5 EKE40510.1 - 0.039 14.2 2.0 0.6 10.4 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4726) LIN52 PF10044.9 EKE40510.1 - 0.17 12.6 5.1 0.35 11.6 5.1 1.4 1 0 0 1 1 1 0 Retinal tissue protein Fib_alpha PF08702.10 EKE40510.1 - 1.9 8.6 9.1 3.2 7.9 9.1 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family YabA PF06156.13 EKE40510.1 - 2.6 8.7 9.4 0.29 11.8 4.3 1.9 1 1 1 2 2 2 0 Initiation control protein YabA Med13_C PF06333.12 EKE40511.1 - 1.1e-05 24.9 0.1 0.12 11.6 0.0 2.2 2 0 0 2 2 2 2 Mediator complex subunit 13 C-terminal domain T3RM_EcoP15I_C PF18273.1 EKE40511.1 - 0.014 15.6 1.6 0.051 13.9 1.6 1.9 1 0 0 1 1 1 0 Type III R-M EcoP15I C-terminal domain UCH PF00443.29 EKE40512.1 - 3.8e-17 62.7 8.4 1e-14 54.7 8.4 3.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE40512.1 - 2.2e-05 24.2 13.1 0.0013 18.5 0.2 3.3 1 1 2 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase TORC_M PF12885.7 EKE40513.1 - 0.93 9.4 7.9 1.1 9.2 4.0 2.6 3 1 0 3 3 3 0 Transducer of regulated CREB activity middle domain C1_1 PF00130.22 EKE40514.1 - 0.00018 21.3 4.4 0.00038 20.3 4.4 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) MapZ_EC1 PF18041.1 EKE40514.1 - 0.0018 18.5 3.8 0.0018 18.5 3.8 3.9 3 0 0 3 3 3 1 MapZ extracellular domain 1 C1_2 PF03107.16 EKE40514.1 - 0.02 15.2 2.9 0.047 14.0 2.9 1.6 1 0 0 1 1 1 0 C1 domain Zn_ribbon_17 PF17120.5 EKE40514.1 - 0.06 13.0 5.8 0.11 12.2 5.8 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type YdjO PF14169.6 EKE40514.1 - 0.13 12.0 3.2 6.9 6.5 0.3 2.7 2 0 0 2 2 2 0 Cold-inducible protein YdjO PHD PF00628.29 EKE40514.1 - 0.24 11.3 7.0 0.52 10.3 7.0 1.6 1 0 0 1 1 1 0 PHD-finger DUF1664 PF07889.12 EKE40514.1 - 0.36 10.9 21.6 0.047 13.7 4.5 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Prot_inhib_II PF02428.15 EKE40514.1 - 1.1 9.7 4.7 2.7 8.5 4.7 1.6 1 0 0 1 1 1 0 Potato type II proteinase inhibitor family Prok-RING_1 PF14446.6 EKE40514.1 - 8.9 6.3 10.7 3.3 7.7 6.2 2.5 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 DNA_pol_A PF00476.20 EKE40515.1 - 2.6e-110 369.0 1.4 4.8e-110 368.1 1.4 1.4 1 0 0 1 1 1 1 DNA polymerase family A START PF01852.19 EKE40516.1 - 4e-11 42.7 0.1 4.8e-11 42.5 0.1 1.2 1 0 0 1 1 1 1 START domain DnaJ_C PF01556.18 EKE40517.1 - 1.8e-33 115.7 3.7 2.4e-33 115.3 3.7 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EKE40517.1 - 1.6e-23 82.6 3.5 3e-23 81.7 3.5 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EKE40517.1 - 2.9e-14 53.2 17.4 4.8e-14 52.5 17.4 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EKE40517.1 - 0.003 17.5 15.6 0.13 12.2 4.0 2.4 1 1 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EKE40517.1 - 0.022 14.8 6.1 0.85 9.7 0.2 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EKE40517.1 - 0.05 13.6 6.2 0.099 12.7 6.2 1.5 1 0 0 1 1 1 0 Double zinc ribbon TackOD1 PF18551.1 EKE40517.1 - 0.079 12.6 4.3 2.3 7.9 0.6 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Cytochrom_c3_2 PF14537.6 EKE40517.1 - 0.48 10.9 8.5 1.2 9.6 8.5 1.7 1 0 0 1 1 1 0 Cytochrome c3 Sar8_2 PF03058.14 EKE40517.1 - 1.7 9.2 5.7 4.7 7.8 3.6 2.5 3 0 0 3 3 3 0 Sar8.2 family Lar_restr_allev PF14354.6 EKE40517.1 - 3.1 8.3 10.5 0.45 10.9 5.2 2.4 2 1 1 3 3 2 0 Restriction alleviation protein Lar zf-C3HC4_3 PF13920.6 EKE40517.1 - 3.4 7.6 7.6 8.5 6.3 0.7 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Sep15_SelM PF08806.11 EKE40518.1 - 7.7e-07 29.2 0.0 1.4e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Sep15/SelM redox domain SH3_2 PF07653.17 EKE40520.1 - 1.4e-09 37.5 0.1 4.1e-09 36.0 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EKE40520.1 - 3.9e-09 36.0 0.1 1.2e-08 34.4 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EKE40520.1 - 1.5e-07 31.2 1.0 3.8e-07 29.9 0.0 2.1 3 0 0 3 3 3 1 Variant SH3 domain SH3_3 PF08239.11 EKE40520.1 - 1.9e-05 24.9 0.2 4.6e-05 23.6 0.2 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain PH PF00169.29 EKE40520.1 - 2.1e-05 25.0 0.6 3.3e-05 24.4 0.6 1.3 1 0 0 1 1 1 1 PH domain Tetraspanin PF00335.20 EKE40521.1 - 0.00031 20.5 14.8 0.0004 20.2 14.8 1.1 1 0 0 1 1 1 1 Tetraspanin family Claudin_2 PF13903.6 EKE40521.1 - 0.017 14.9 5.3 0.04 13.7 2.4 2.1 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Gaa1 PF04114.14 EKE40521.1 - 0.051 12.6 7.0 0.064 12.3 7.0 1.2 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component DUF3810 PF12725.7 EKE40521.1 - 0.18 11.1 7.3 0.4 10.0 7.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) DUF2207 PF09972.9 EKE40521.1 - 0.19 10.4 2.9 2 7.1 2.9 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Sm_multidrug_ex PF06695.11 EKE40521.1 - 0.27 11.9 5.6 1.4 9.6 3.4 2.8 2 1 0 2 2 2 0 Putative small multi-drug export protein MscS_TM PF12794.7 EKE40521.1 - 0.45 9.3 4.9 0.53 9.1 2.9 2.0 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 OAD_gamma PF04277.13 EKE40521.1 - 0.53 10.9 5.6 2.4 8.8 1.0 2.9 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DHHC PF01529.20 EKE40521.1 - 3.9 7.6 19.8 0.18 11.9 9.4 2.6 2 1 1 3 3 3 0 DHHC palmitoyltransferase DUF5465 PF17553.2 EKE40521.1 - 4.8 8.0 11.2 0.42 11.2 1.1 3.1 2 1 0 2 2 2 0 Family of unknown function (DUF5465) SRF-TF PF00319.18 EKE40522.1 - 2.1e-19 68.7 0.9 3.5e-19 68.0 0.9 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) UBX PF00789.20 EKE40523.1 - 3.1e-12 46.5 0.0 8.4e-12 45.1 0.0 1.7 1 0 0 1 1 1 1 UBX domain DUF740 PF05340.12 EKE40523.1 - 6.1 5.5 16.8 8.1 5.1 16.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Ndc1_Nup PF09531.10 EKE40523.1 - 6.3 5.4 9.8 7.3 5.2 9.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Asp-B-Hydro_N PF05279.11 EKE40523.1 - 9.2 6.2 26.7 15 5.6 26.7 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region UBX PF00789.20 EKE40524.1 - 0.00011 22.4 0.0 0.00043 20.4 0.0 2.1 1 0 0 1 1 1 1 UBX domain LMBR1 PF04791.16 EKE40524.1 - 3.2 6.6 16.2 4.6 6.0 16.2 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein RhoGAP PF00620.27 EKE40525.1 - 2e-15 56.9 0.1 2.8e-15 56.4 0.1 1.2 1 0 0 1 1 1 1 RhoGAP domain PP2C_2 PF13672.6 EKE40526.1 - 8.3e-08 32.1 0.0 4.5e-07 29.7 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE40526.1 - 0.00042 20.3 0.0 0.00098 19.1 0.0 1.5 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Med9 PF07544.13 EKE40527.1 - 0.043 13.9 1.1 0.064 13.4 1.1 1.3 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF1635 PF07795.11 EKE40529.1 - 0.14 11.9 6.0 0.22 11.4 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) FHIPEP PF00771.20 EKE40529.1 - 0.16 10.4 5.2 0.19 10.1 5.2 1.1 1 0 0 1 1 1 0 FHIPEP family DivIC PF04977.15 EKE40529.1 - 2.2 8.1 7.3 2.5 7.9 5.0 2.2 2 0 0 2 2 2 0 Septum formation initiator RhoGAP PF00620.27 EKE40531.1 - 1.2e-27 96.6 0.4 6e-27 94.3 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 EKE40531.1 - 0.049 14.2 1.7 0.098 13.2 0.1 2.4 2 1 0 2 2 2 0 PH domain LIN52 PF10044.9 EKE40531.1 - 0.2 12.4 2.1 0.59 10.9 0.7 2.4 2 0 0 2 2 2 0 Retinal tissue protein ABC_tran PF00005.27 EKE40533.1 - 1.3e-09 38.7 0.0 1.3e-09 38.7 0.0 2.6 2 1 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 EKE40533.1 - 0.0018 18.1 0.5 0.0083 16.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system PduV-EutP PF10662.9 EKE40533.1 - 0.0019 17.9 1.6 0.13 12.0 0.0 2.5 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EKE40533.1 - 0.0042 16.6 0.1 2.1 7.8 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_22 PF13401.6 EKE40533.1 - 0.016 15.5 0.0 0.054 13.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EKE40533.1 - 0.042 13.6 0.0 0.078 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP-synt_ab PF00006.25 EKE40533.1 - 0.051 13.2 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_16 PF13191.6 EKE40533.1 - 0.072 13.5 0.0 0.28 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.6 EKE40533.1 - 0.095 12.9 0.5 0.41 10.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EKE40533.1 - 0.095 12.8 0.1 0.095 12.8 0.1 3.0 2 2 0 2 2 2 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE40533.1 - 0.11 12.3 1.1 0.5 10.3 0.0 2.5 1 1 1 2 2 2 0 RsgA GTPase AAA_23 PF13476.6 EKE40533.1 - 0.21 12.1 0.0 0.21 12.1 0.0 4.1 3 1 0 3 3 2 0 AAA domain DUF87 PF01935.17 EKE40533.1 - 0.43 10.6 0.0 0.43 10.6 0.0 3.1 2 1 0 2 2 1 0 Helicase HerA, central domain AAA_15 PF13175.6 EKE40533.1 - 1.9 8.1 28.9 0.11 12.2 0.8 2.6 2 1 0 2 2 2 0 AAA ATPase domain Thioredoxin_4 PF13462.6 EKE40533.1 - 3.4 7.8 12.2 0.22 11.6 1.0 3.3 2 1 1 3 3 3 0 Thioredoxin NIF3 PF01784.18 EKE40534.1 - 6.1e-66 222.5 0.0 7.4e-66 222.3 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) SPA PF08616.10 EKE40535.1 - 1.5e-12 47.5 0.0 3.4e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EKE40535.1 - 3.2e-10 39.3 0.7 1.1e-07 30.9 0.4 2.9 2 1 0 2 2 2 2 Transport protein Avl9 Oscp1 PF10188.9 EKE40536.1 - 0.028 14.6 1.7 0.039 14.1 1.7 1.2 1 0 0 1 1 1 0 Organic solute transport protein 1 SPRY PF00622.28 EKE40537.1 - 5.3e-12 45.9 0.8 1.4e-11 44.5 0.8 1.8 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.6 EKE40537.1 - 1.2e-09 37.8 12.9 1.2e-09 37.8 12.9 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE40537.1 - 0.00031 20.6 18.2 0.00091 19.0 18.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE40537.1 - 0.0016 18.7 17.0 0.0016 18.7 17.0 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKE40537.1 - 0.0017 18.2 16.6 0.0046 16.8 16.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE40537.1 - 0.0034 17.2 14.1 0.0034 17.2 14.1 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EKE40537.1 - 0.02 15.0 9.1 0.067 13.3 9.1 1.9 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_5 PF14634.6 EKE40537.1 - 0.024 14.6 16.5 0.059 13.3 16.5 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EKE40537.1 - 3.6 7.8 13.5 13 6.1 13.5 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 EKE40537.1 - 8.8 6.2 12.1 78 3.2 0.0 2.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain TLD PF07534.16 EKE40538.1 - 4.1e-07 30.3 2.2 1e-06 29.0 2.2 1.7 1 1 0 1 1 1 1 TLD GpcrRhopsn4 PF10192.9 EKE40539.1 - 0.0032 16.9 37.1 0.0032 16.9 37.1 2.2 2 1 1 3 3 3 1 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.13 EKE40539.1 - 0.0061 15.8 33.6 0.015 14.5 33.6 1.7 1 1 0 1 1 1 1 Lung seven transmembrane receptor DUF1192 PF06698.11 EKE40539.1 - 0.046 13.8 0.1 0.081 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Dna2 PF08696.11 EKE40540.1 - 6.4e-36 124.1 0.3 1.8e-35 122.6 0.3 1.8 1 0 0 1 1 1 1 DNA replication factor Dna2 PDDEXK_1 PF12705.7 EKE40540.1 - 1.4e-08 35.0 0.0 2.5e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Cas_Cas4 PF01930.17 EKE40540.1 - 9.8e-05 22.5 0.1 0.00031 20.9 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function DUF83 DUF2200 PF09966.9 EKE40540.1 - 0.00025 21.2 0.6 0.0023 18.0 0.1 2.6 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2200) Csa1 PF06023.12 EKE40540.1 - 0.067 12.5 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated exonuclease Csa1 DUF2207 PF09972.9 EKE40541.1 - 0.73 8.5 4.1 6.3 5.4 4.2 2.1 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) LIM PF00412.22 EKE40542.1 - 7.4e-09 35.7 6.5 1.3e-08 34.9 6.5 1.4 1 0 0 1 1 1 1 LIM domain SelR PF01641.18 EKE40542.1 - 0.0055 16.8 2.2 0.0055 16.8 2.2 2.0 1 1 1 2 2 2 1 SelR domain DUF4428 PF14471.6 EKE40542.1 - 0.027 14.4 4.9 0.13 12.2 4.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) zf-met PF12874.7 EKE40542.1 - 0.15 12.5 0.2 0.15 12.5 0.2 2.9 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DNA_ligase_ZBD PF03119.16 EKE40542.1 - 0.22 11.6 2.2 0.79 9.8 2.2 2.2 1 1 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Zn_Tnp_IS1595 PF12760.7 EKE40542.1 - 0.23 11.4 5.6 0.29 11.2 3.6 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain C1_2 PF03107.16 EKE40542.1 - 0.31 11.4 3.7 0.84 10.0 1.0 2.3 2 0 0 2 2 2 0 C1 domain RhoGAP PF00620.27 EKE40543.1 - 2.1e-17 63.3 0.1 3.9e-17 62.5 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain MIP PF00230.20 EKE40544.1 - 7.9e-12 45.4 11.1 3.1e-07 30.3 5.3 2.1 1 1 1 2 2 2 2 Major intrinsic protein Vpu PF00558.19 EKE40544.1 - 0.14 11.9 0.0 0.49 10.2 0.0 1.9 1 0 0 1 1 1 0 Vpu protein MFS_1 PF07690.16 EKE40545.1 - 8.4e-35 120.3 17.5 1.4e-21 76.8 0.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EKE40545.1 - 0.0016 16.9 0.0 0.0016 16.9 0.0 2.7 2 1 1 3 3 3 1 Transmembrane secretion effector Zip PF02535.22 EKE40545.1 - 0.011 14.9 0.5 0.048 12.9 0.1 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Wzy_C PF04932.15 EKE40545.1 - 1.4 8.5 13.0 25 4.5 13.2 2.8 2 1 0 2 2 2 0 O-Antigen ligase LapA_dom PF06305.11 EKE40545.1 - 3.4 7.5 11.9 3.2 7.7 1.6 4.6 5 0 0 5 5 5 0 Lipopolysaccharide assembly protein A domain CH PF00307.31 EKE40547.1 - 9.1e-17 61.2 17.4 7.5e-12 45.4 0.7 4.7 4 0 0 4 4 4 2 Calponin homology (CH) domain UFD1 PF03152.14 EKE40548.1 - 2.1e-42 144.5 0.6 3.6e-42 143.8 0.6 1.3 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 zf-TRAF PF02176.18 EKE40548.1 - 1.9e-08 34.9 27.1 4.6e-08 33.6 5.4 3.6 2 1 1 3 3 3 2 TRAF-type zinc finger zf-C2H2_4 PF13894.6 EKE40548.1 - 4.6e-05 23.9 22.6 0.25 12.3 0.3 6.7 6 0 0 6 6 6 2 C2H2-type zinc finger zf_UBZ PF18439.1 EKE40548.1 - 0.017 14.7 26.5 0.88 9.2 0.1 6.4 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger Zn-C2H2_12 PF18112.1 EKE40548.1 - 0.022 15.2 0.2 0.022 15.2 0.2 4.6 5 0 0 5 5 3 0 Autophagy receptor zinc finger-C2H2 domain Lar_restr_allev PF14354.6 EKE40548.1 - 0.049 14.0 15.7 0.096 13.1 0.7 3.5 3 1 1 4 4 4 0 Restriction alleviation protein Lar zf-Di19 PF05605.12 EKE40548.1 - 1.6 9.1 31.4 0.21 11.9 4.0 4.8 3 2 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding PRP21_like_P PF12230.8 EKE40548.1 - 1.7 8.5 11.0 13 5.6 0.3 3.9 1 1 3 4 4 4 0 Pre-mRNA splicing factor PRP21 like protein zf_C2H2_13 PF18508.1 EKE40548.1 - 1.8 8.2 13.1 15 5.3 0.9 3.8 2 1 1 3 3 3 0 Zinc finger domain zf-C4_Topoisom PF01396.19 EKE40548.1 - 3.2 7.6 14.5 24 4.8 0.1 5.0 5 0 0 5 5 5 0 Topoisomerase DNA binding C4 zinc finger zf-C2H2_9 PF16293.5 EKE40548.1 - 5.6 6.9 8.6 4.6 7.2 1.2 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) UBZ_FAAP20 PF15750.5 EKE40548.1 - 5.9 6.9 14.6 0.15 12.0 2.8 3.1 4 0 0 4 4 3 0 Ubiquitin-binding zinc-finger zf-LYAR PF08790.11 EKE40548.1 - 6.1 6.8 8.5 32 4.5 0.0 3.7 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Cys_rich_KTR PF14205.6 EKE40548.1 - 7.8 6.4 8.4 23 4.9 2.6 3.1 3 0 0 3 3 3 0 Cysteine-rich KTR Clathrin PF00637.20 EKE40549.1 - 0.0072 16.2 11.7 0.2 11.5 0.5 4.3 3 1 1 4 4 4 2 Region in Clathrin and VPS zf-C2H2_11 PF16622.5 EKE40550.1 - 0.016 14.9 3.3 0.038 13.7 1.8 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type Pkinase_Tyr PF07714.17 EKE40551.1 - 3.2e-30 105.3 0.0 5.2e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40551.1 - 5.4e-30 104.7 0.0 8.1e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 EKE40551.1 - 8.3e-06 25.8 0.0 2e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 SH2 domain eRF1_1 PF03463.15 EKE40552.1 - 4.9e-22 78.3 1.3 6.7e-22 77.9 0.3 1.7 2 0 0 2 2 2 1 eRF1 domain 1 eRF1_3 PF03465.15 EKE40552.1 - 8.7e-14 52.0 0.5 2.3e-13 50.6 0.5 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 EKE40552.1 - 6.8e-08 32.9 0.0 1.4e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 2 baeRF_family10 PF18854.1 EKE40552.1 - 0.15 12.3 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 DUF382 PF04037.13 EKE40553.1 - 4.1e-47 159.5 0.8 7e-47 158.7 0.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 EKE40553.1 - 1.2e-11 44.3 0.7 2.8e-11 43.1 0.7 1.6 1 0 0 1 1 1 1 PSP Man-6-P_recep PF02157.15 EKE40554.1 - 4.2e-08 32.6 0.0 5.4e-08 32.2 0.0 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 EKE40554.1 - 6e-07 29.6 0.1 6.6e-06 26.2 0.1 1.9 1 1 1 2 2 2 1 Autophagy-related protein 27 PRKCSH_1 PF13015.6 EKE40554.1 - 0.00034 20.3 0.0 0.00046 19.9 0.0 1.1 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein MMPL PF03176.15 EKE40554.1 - 0.0069 15.4 0.0 0.0077 15.2 0.0 1.1 1 0 0 1 1 1 1 MMPL family PARM PF17061.5 EKE40554.1 - 0.056 13.6 0.9 0.076 13.1 0.9 1.1 1 0 0 1 1 1 0 PARM Epiglycanin_C PF14654.6 EKE40554.1 - 0.13 12.3 1.4 0.48 10.5 0.8 1.9 2 0 0 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region Insulin_TMD PF17870.1 EKE40554.1 - 0.45 10.6 5.0 1.3 9.2 4.4 2.1 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment DUF4083 PF13314.6 EKE40554.1 - 2.9 7.9 5.8 12 5.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) Methyltransf_23 PF13489.6 EKE40555.1 - 3.1e-13 49.9 0.0 4.4e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EKE40555.1 - 3e-12 47.1 0.0 4.6e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE40555.1 - 2.4e-11 44.2 0.0 3.7e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKE40555.1 - 6.2e-11 42.8 0.0 1.2e-10 41.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EKE40555.1 - 7.4e-09 35.6 0.0 8.5e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EKE40555.1 - 0.00044 19.7 0.1 0.0048 16.4 0.0 2.3 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_24 PF13578.6 EKE40555.1 - 0.00048 21.1 0.0 0.00076 20.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.12 EKE40555.1 - 0.015 15.1 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) MTS PF05175.14 EKE40555.1 - 0.027 14.0 0.0 0.043 13.4 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_8 PF05148.15 EKE40555.1 - 0.052 13.4 0.0 0.23 11.3 0.0 2.0 1 1 0 1 1 1 0 Hypothetical methyltransferase DUF1583 PF07622.11 EKE40555.1 - 0.1 11.4 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1583) TMEM144 PF07857.12 EKE40556.1 - 8.5e-94 314.3 14.1 4.3e-93 311.9 14.1 1.8 1 1 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 EKE40556.1 - 4.5e-09 36.1 21.3 7.6e-08 32.0 4.9 2.9 2 1 1 3 3 3 3 Sugar transport protein Ureide_permease PF07168.11 EKE40556.1 - 1.9e-05 23.6 0.5 0.0011 17.8 0.5 2.2 1 1 0 1 1 1 1 Ureide permease ALG3 PF05208.13 EKE40556.1 - 0.013 15.0 0.1 0.019 14.4 0.1 1.3 1 0 0 1 1 1 0 ALG3 protein DUF2407_C PF13373.6 EKE40556.1 - 5.9 7.1 6.8 4.3 7.5 0.0 3.0 3 0 0 3 3 3 0 DUF2407 C-terminal domain WWE PF02825.20 EKE40559.1 - 6.1e-06 26.7 7.6 6.1e-06 26.7 7.6 2.8 3 0 0 3 3 3 1 WWE domain FPL PF09758.9 EKE40560.1 - 1.4e-46 158.1 6.0 8.3e-46 155.7 4.2 2.7 2 0 0 2 2 2 1 Uncharacterised conserved protein CDP-OH_P_transf PF01066.21 EKE40561.1 - 5.8e-11 43.0 2.8 5.8e-11 43.0 2.8 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase RIBIOP_C PF04950.12 EKE40562.1 - 1.2e-75 254.6 3.1 1.2e-75 254.6 3.1 2.5 3 0 0 3 3 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EKE40562.1 - 3e-29 100.9 2.2 4.4e-29 100.4 0.0 2.5 3 0 0 3 3 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 EKE40562.1 - 1.8e-06 27.7 1.5 0.0001 21.9 0.0 3.2 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain Rad17 PF03215.15 EKE40562.1 - 2.5e-06 27.5 0.3 1.7e-05 24.8 0.0 2.2 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 EKE40562.1 - 7.1e-06 26.3 0.0 6.5e-05 23.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EKE40562.1 - 4.9e-05 23.8 0.0 0.00016 22.1 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EKE40562.1 - 0.00031 20.9 0.0 0.0014 18.8 0.0 2.3 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EKE40562.1 - 0.0012 18.6 0.0 0.0027 17.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 EKE40562.1 - 0.0013 19.1 0.0 0.0041 17.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EKE40562.1 - 0.0017 18.7 0.0 0.0043 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 EKE40562.1 - 0.0032 17.2 0.2 0.014 15.1 0.2 2.0 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 EKE40562.1 - 0.0033 18.0 0.1 0.0033 18.0 0.1 3.9 3 1 1 4 4 2 1 AAA domain NACHT PF05729.12 EKE40562.1 - 0.0035 17.3 0.0 0.0066 16.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Viral_helicase1 PF01443.18 EKE40562.1 - 0.0039 17.0 2.8 0.0047 16.7 0.1 2.5 3 0 0 3 3 2 1 Viral (Superfamily 1) RNA helicase PRK PF00485.18 EKE40562.1 - 0.0072 16.1 0.0 0.022 14.5 0.0 1.8 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family ABC_tran PF00005.27 EKE40562.1 - 0.0081 16.7 6.2 0.021 15.4 0.0 3.8 3 0 0 3 3 3 1 ABC transporter RNA_helicase PF00910.22 EKE40562.1 - 0.011 16.1 0.0 0.011 16.1 0.0 3.4 3 0 0 3 3 3 0 RNA helicase NTPase_1 PF03266.15 EKE40562.1 - 0.014 15.3 0.3 0.036 14.0 0.3 1.7 1 0 0 1 1 1 0 NTPase AAA_28 PF13521.6 EKE40562.1 - 0.015 15.5 0.0 0.053 13.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EKE40562.1 - 0.018 14.8 0.0 0.064 13.0 0.0 2.0 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 EKE40562.1 - 0.019 14.7 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EKE40562.1 - 0.023 14.4 0.1 0.064 12.9 0.1 1.8 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain T2SSE PF00437.20 EKE40562.1 - 0.026 13.6 0.0 0.058 12.4 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein RsgA_GTPase PF03193.16 EKE40562.1 - 0.027 14.4 0.0 0.095 12.6 0.0 2.0 1 0 0 1 1 1 0 RsgA GTPase cobW PF02492.19 EKE40562.1 - 0.029 14.0 0.1 0.091 12.3 0.1 1.8 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 EKE40562.1 - 0.063 13.3 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 EKE40562.1 - 0.094 12.8 1.8 0.27 11.3 0.0 2.8 2 1 0 2 2 1 0 50S ribosome-binding GTPase AAA_17 PF13207.6 EKE40562.1 - 0.27 11.6 0.1 0.27 11.6 0.1 4.6 4 1 1 6 6 2 0 AAA domain Gaa1 PF04114.14 EKE40563.1 - 5.6e-12 45.4 17.9 1e-10 41.2 17.9 2.2 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component DUF1072 PF06380.11 EKE40563.1 - 0.041 13.8 0.7 0.041 13.8 0.7 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1072) Kinesin PF00225.23 EKE40564.1 - 1.9e-75 253.9 1.1 1.9e-75 253.9 1.1 1.9 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EKE40564.1 - 3.7e-18 65.9 0.2 1.2e-17 64.2 0.2 1.9 1 0 0 1 1 1 1 Microtubule binding HALZ PF02183.18 EKE40564.1 - 0.036 14.3 5.8 0.036 14.3 5.8 2.5 2 1 0 2 2 2 0 Homeobox associated leucine zipper Phage_GP20 PF06810.11 EKE40564.1 - 0.71 9.7 10.8 0.095 12.5 4.4 2.4 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF87 PF01935.17 EKE40564.1 - 1.3 9.0 13.8 8 6.5 5.8 3.1 3 1 0 3 3 3 0 Helicase HerA, central domain NRBF2 PF08961.10 EKE40564.1 - 2.3 7.8 19.9 0.15 11.6 4.2 2.3 1 1 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator TMF_TATA_bd PF12325.8 EKE40564.1 - 3.7 7.8 19.8 1.6 9.0 9.0 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding YabA PF06156.13 EKE40564.1 - 4.4 8.0 17.0 1.8 9.2 3.1 3.0 3 0 0 3 3 3 0 Initiation control protein YabA bZIP_1 PF00170.21 EKE40564.1 - 5.4 7.2 19.6 0.061 13.4 4.8 3.2 2 1 0 2 2 2 0 bZIP transcription factor FF PF01846.19 EKE40565.1 - 0.092 12.9 0.4 1.6 9.0 0.0 3.1 3 0 0 3 3 3 0 FF domain fn1 PF00039.18 EKE40565.1 - 0.1 12.8 0.1 0.43 10.8 0.3 1.9 2 0 0 2 2 2 0 Fibronectin type I domain GCR1_C PF12550.8 EKE40565.1 - 0.11 12.9 0.5 4 7.8 0.0 3.1 3 0 0 3 3 3 0 Transcriptional activator of glycolytic enzymes TFIID-31kDa PF02291.15 EKE40565.1 - 0.2 11.8 6.2 3.9 7.6 0.0 4.0 4 0 0 4 4 4 0 Transcription initiation factor IID, 31kD subunit PEN-2 PF10251.9 EKE40567.1 - 0.00096 19.5 2.6 0.0015 18.9 2.6 1.3 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase WTF PF03303.13 EKE40567.1 - 0.062 13.0 2.1 0.07 12.9 2.1 1.1 1 0 0 1 1 1 0 WTF protein DUF2207 PF09972.9 EKE40567.1 - 0.25 10.1 2.3 0.29 9.9 2.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) UL45 PF05473.12 EKE40567.1 - 3.2 7.4 5.9 16 5.1 5.9 1.9 1 1 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like TRADD_N PF09034.10 EKE40569.1 - 0.034 14.2 0.1 0.051 13.6 0.1 1.3 1 0 0 1 1 1 0 TRADD, N-terminal domain bZIP_Maf PF03131.17 EKE40570.1 - 0.0007 20.1 7.4 0.00089 19.7 7.4 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor AAA_23 PF13476.6 EKE40570.1 - 0.01 16.3 10.7 0.014 15.9 10.7 1.2 1 0 0 1 1 1 0 AAA domain DUF16 PF01519.16 EKE40570.1 - 0.033 14.7 8.4 0.045 14.3 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 UPF0242 PF06785.11 EKE40570.1 - 0.049 13.7 8.8 0.062 13.4 8.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PRP1_N PF06424.12 EKE40570.1 - 0.24 11.8 3.3 0.3 11.5 3.3 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal bZIP_2 PF07716.15 EKE40570.1 - 7.2 6.8 14.3 0.32 11.1 7.3 2.3 1 1 2 3 3 3 0 Basic region leucine zipper Mlh1_C PF16413.5 EKE40571.1 - 5.1e-43 147.4 4.6 5.1e-43 147.4 4.6 3.6 3 1 0 3 3 3 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EKE40571.1 - 8.1e-21 73.9 1.6 2.3e-20 72.5 1.6 1.8 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EKE40571.1 - 1.2e-09 38.1 3.2 2e-09 37.4 0.0 2.6 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EKE40571.1 - 1.9e-08 34.8 0.9 5.6e-08 33.3 0.4 2.1 1 1 1 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TrmO PF01980.16 EKE40572.1 - 2.2e-36 124.7 0.0 4.3e-36 123.7 0.0 1.5 1 0 0 1 1 1 1 tRNA-methyltransferase O TrmO_C PF18389.1 EKE40572.1 - 2e-05 24.6 0.0 4.5e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 TrmO C-terminal domain HSP20 PF00011.21 EKE40573.1 - 2.5e-15 56.5 0.0 3.7e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EKE40573.1 - 7e-05 22.3 0.0 0.0001 21.8 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA DUF5460 PF17544.2 EKE40574.1 - 0.041 12.9 0.8 0.11 11.5 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5460) zf-CCCH PF00642.24 EKE40575.1 - 4.3e-18 64.7 15.3 9e-10 38.2 2.5 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EKE40575.1 - 4.9e-13 48.7 18.1 2.8e-07 30.4 4.3 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EKE40575.1 - 2.7e-10 39.8 14.8 1.3e-05 24.9 5.1 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 EKE40575.1 - 1.6e-07 32.0 8.8 0.0046 17.6 2.2 2.3 1 1 1 2 2 2 2 Torus domain zf-CCCH_2 PF14608.6 EKE40575.1 - 0.0002 21.7 16.5 0.02 15.4 3.7 2.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EKE40575.1 - 0.00028 21.1 11.7 0.011 16.0 2.5 2.3 1 1 1 2 2 2 2 Zinc-finger containing family DUF4789 PF16033.5 EKE40575.1 - 0.47 11.0 7.2 2 9.0 2.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4789) Pkinase PF00069.25 EKE40576.1 - 3.1e-61 207.1 0.1 7.2e-61 205.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40576.1 - 2.5e-32 112.2 0.0 4.4e-32 111.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EKE40576.1 - 1.7e-06 28.1 0.0 0.074 13.0 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family PH PF00169.29 EKE40576.1 - 0.00027 21.4 0.0 0.00095 19.7 0.0 2.0 1 0 0 1 1 1 1 PH domain Haspin_kinase PF12330.8 EKE40576.1 - 0.00081 18.4 1.1 0.0019 17.2 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EKE40576.1 - 0.001 18.4 0.0 0.0025 17.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EKE40576.1 - 0.0053 15.9 0.0 0.015 14.4 0.0 1.7 1 0 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.22 EKE40576.1 - 0.038 13.6 0.0 0.084 12.5 0.0 1.5 1 0 0 1 1 1 0 RIO1 family TIP49 PF06068.13 EKE40576.1 - 0.048 12.8 0.7 0.084 12.1 0.7 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain TPR_19 PF14559.6 EKE40577.1 - 0.13 12.7 0.3 1.2 9.7 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Cyclin_N PF00134.23 EKE40578.1 - 0.0054 16.5 0.2 0.011 15.4 0.2 1.6 1 1 0 1 1 1 1 Cyclin, N-terminal domain HSF_DNA-bind PF00447.17 EKE40579.1 - 2.3e-15 57.0 3.3 6.8e-15 55.5 3.3 1.8 1 0 0 1 1 1 1 HSF-type DNA-binding COG5 PF10392.9 EKE40579.1 - 0.014 15.6 0.7 0.014 15.6 0.7 2.9 3 1 0 3 3 3 0 Golgi transport complex subunit 5 zf-BED PF02892.15 EKE40580.1 - 0.012 15.6 1.4 0.032 14.3 1.4 1.8 1 1 0 1 1 1 0 BED zinc finger Ras PF00071.22 EKE40581.1 - 1.6e-25 89.6 1.8 1.9e-25 89.3 1.8 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40581.1 - 1.2e-11 44.8 0.3 2.8e-11 43.7 0.3 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40581.1 - 1.1e-07 31.5 1.4 1.3e-07 31.2 1.4 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE40581.1 - 0.00064 19.7 0.6 0.41 10.5 0.2 2.6 2 1 1 3 3 3 2 RsgA GTPase Septin PF00735.18 EKE40581.1 - 0.0041 16.4 0.0 0.0074 15.6 0.0 1.4 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EKE40581.1 - 0.01 15.9 0.1 0.018 15.1 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 EKE40581.1 - 0.018 14.6 0.3 0.11 12.1 0.1 2.1 1 1 1 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 EKE40581.1 - 0.037 13.2 0.8 0.075 12.2 0.8 1.9 1 1 0 1 1 1 0 NB-ARC domain DUF4894 PF16235.5 EKE40581.1 - 0.045 14.1 0.7 0.066 13.6 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4894) TsaE PF02367.17 EKE40581.1 - 0.05 13.6 0.1 0.097 12.7 0.1 1.5 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 EKE40581.1 - 0.086 12.6 1.9 6.6 6.5 1.9 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 EKE40581.1 - 0.086 13.0 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EKE40581.1 - 0.19 11.4 4.2 0.51 10.0 3.8 2.2 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 EKE40581.1 - 0.22 11.1 2.0 4.1 7.0 0.2 2.5 1 1 1 2 2 2 0 SRP54-type protein, GTPase domain F-box PF00646.33 EKE40582.1 - 0.00034 20.4 0.0 0.001 18.9 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EKE40582.1 - 0.016 15.1 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 F-box-like LIM PF00412.22 EKE40583.1 - 5.1e-10 39.4 4.4 7.8e-10 38.8 4.4 1.3 1 0 0 1 1 1 1 LIM domain zf-3CxxC_2 PF17180.4 EKE40583.1 - 0.34 11.7 5.3 1 10.1 0.6 2.8 1 1 2 3 3 3 0 Zinc-binding domain MRNIP PF15749.5 EKE40583.1 - 7.1 7.4 7.3 28 5.5 7.3 2.0 1 1 0 1 1 1 0 MRN-interacting protein DUF4870 PF09685.10 EKE40584.1 - 4.7e-07 29.9 13.5 5.3e-07 29.7 13.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4870) Cation_efflux PF01545.21 EKE40584.1 - 0.0095 15.7 8.0 0.012 15.3 8.0 1.1 1 0 0 1 1 1 1 Cation efflux family DUF3021 PF11457.8 EKE40584.1 - 0.01 16.1 12.9 0.014 15.7 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DUF2516 PF10724.9 EKE40584.1 - 0.15 12.3 7.3 0.24 11.7 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2516) Ndc1_Nup PF09531.10 EKE40584.1 - 0.38 9.4 4.1 0.55 8.9 4.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Phtf-FEM1B_bdg PF12129.8 EKE40584.1 - 0.4 10.5 5.2 0.51 10.2 5.2 1.3 1 0 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor Serinc PF03348.15 EKE40584.1 - 0.46 9.3 11.6 0.55 9.1 11.6 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF2070 PF09843.9 EKE40584.1 - 1.7 6.8 11.9 2 6.6 11.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) RL PF17797.1 EKE40584.1 - 2.4 8.2 4.6 5.4 7.0 4.6 1.5 1 0 0 1 1 1 0 RL domain Ac81 PF05820.11 EKE40584.1 - 6.2 6.4 11.4 7.8 6.0 11.4 1.2 1 0 0 1 1 1 0 Baculoviridae AC81 F-box-like PF12937.7 EKE40585.1 - 0.0035 17.2 1.6 0.02 14.8 0.1 2.6 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EKE40585.1 - 0.0044 16.9 0.1 0.058 13.3 0.0 2.5 2 0 0 2 2 2 1 F-box domain Gtr1_RagA PF04670.12 EKE40585.1 - 0.042 13.2 0.1 0.098 12.0 0.0 1.6 1 1 1 2 2 2 0 Gtr1/RagA G protein conserved region DEAD PF00270.29 EKE40586.1 - 8.7e-48 162.4 0.0 2.1e-47 161.2 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE40586.1 - 9.8e-33 112.8 0.3 4.2e-30 104.3 0.3 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EKE40586.1 - 5.2e-05 23.3 0.0 0.00013 22.0 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EKE40586.1 - 0.9 9.3 0.0 0.9 9.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain IF-2B PF01008.17 EKE40587.1 - 6.5e-50 169.9 0.5 3.7e-49 167.4 0.5 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family Met_gamma_lyase PF06838.11 EKE40587.1 - 0.049 12.2 0.0 0.066 11.7 0.0 1.2 1 0 0 1 1 1 0 Methionine gamma-lyase Lysozyme_like PF13702.6 EKE40587.1 - 0.089 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Lysozyme-like Rtt106_N PF18215.1 EKE40587.1 - 0.095 12.5 0.1 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 Histone chaperone Rtt106 N-terminal domain Importin_rep_3 PF18806.1 EKE40587.1 - 0.12 12.4 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Importin 13 repeat OST3_OST6 PF04756.13 EKE40588.1 - 8.3e-05 22.1 3.2 0.0001 21.8 3.2 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Pkinase_Tyr PF07714.17 EKE40590.1 - 4.2e-19 68.8 0.0 8.1e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40590.1 - 1.5e-17 63.8 0.0 3.5e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE40590.1 - 0.0019 17.1 0.0 0.0029 16.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Ras PF00071.22 EKE40591.1 - 1.2e-13 51.0 0.1 1.4e-13 50.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40591.1 - 6e-05 23.2 0.0 9.2e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Adeno_Penton_B PF01686.17 EKE40591.1 - 0.0061 15.1 0.1 0.0077 14.8 0.1 1.1 1 0 0 1 1 1 1 Adenovirus penton base protein DDE_Tnp_ISL3 PF01610.17 EKE40591.1 - 0.16 11.6 0.0 7.2 6.3 0.0 2.3 2 0 0 2 2 2 0 Transposase DUF1664 PF07889.12 EKE40592.1 - 0.018 15.1 10.4 0.018 15.1 10.4 4.3 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Thioredoxin PF00085.20 EKE40593.1 - 2.7e-28 98.0 0.0 3.3e-28 97.7 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EKE40593.1 - 3.5e-05 24.2 0.1 0.00038 20.9 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EKE40593.1 - 0.00016 21.4 0.0 0.00018 21.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EKE40593.1 - 0.00059 20.1 0.0 0.00097 19.4 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like Phosducin PF02114.16 EKE40593.1 - 0.00082 18.4 0.0 0.00088 18.3 0.0 1.0 1 0 0 1 1 1 1 Phosducin AhpC-TSA PF00578.21 EKE40593.1 - 0.001 19.0 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EKE40593.1 - 0.028 14.1 0.1 0.061 13.0 0.1 1.4 1 1 0 1 1 1 0 Redoxin Thioredoxin_7 PF13899.6 EKE40593.1 - 0.039 14.1 0.1 0.08 13.1 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin-like TraF PF13728.6 EKE40593.1 - 0.094 12.5 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein EMP24_GP25L PF01105.24 EKE40594.1 - 7.2e-33 114.1 2.9 9e-33 113.7 2.9 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Ras PF00071.22 EKE40595.1 - 2.9e-53 179.8 0.2 3.4e-53 179.5 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40595.1 - 1e-33 116.1 0.1 1.5e-33 115.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40595.1 - 8.1e-18 64.5 0.1 1e-17 64.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE40595.1 - 3.9e-08 32.9 0.2 4.6e-08 32.7 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE40595.1 - 8.6e-06 25.8 0.2 1.3e-05 25.2 0.2 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EKE40595.1 - 0.00016 21.4 0.6 0.0017 18.1 0.6 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EKE40595.1 - 0.00038 20.4 0.1 0.74 9.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EKE40595.1 - 0.00059 19.4 0.4 0.0028 17.2 0.1 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 EKE40595.1 - 0.0008 19.0 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region SRPRB PF09439.10 EKE40595.1 - 0.0027 17.2 0.0 0.0044 16.5 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit TniB PF05621.11 EKE40595.1 - 0.0033 16.9 0.0 0.012 15.0 0.0 1.9 2 0 0 2 2 2 1 Bacterial TniB protein FeoB_N PF02421.18 EKE40595.1 - 0.0042 16.6 1.6 0.029 13.9 1.6 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.18 EKE40595.1 - 0.0066 15.8 0.2 0.019 14.3 0.0 1.8 2 0 0 2 2 2 1 Septin MCM PF00493.23 EKE40595.1 - 0.0071 15.5 0.0 0.014 14.5 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain AAA_22 PF13401.6 EKE40595.1 - 0.0082 16.4 0.0 0.02 15.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EKE40595.1 - 0.015 15.7 0.0 0.024 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ATP-synt_ab PF00006.25 EKE40595.1 - 0.058 13.0 0.0 0.09 12.4 0.0 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 EKE40595.1 - 0.063 13.7 0.0 0.17 12.3 0.0 1.9 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EKE40595.1 - 0.073 13.1 0.0 0.16 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EKE40595.1 - 0.17 11.8 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain HA2 PF04408.23 EKE40596.1 - 1.8e-21 76.5 0.0 3.7e-21 75.4 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EKE40596.1 - 3.7e-15 56.2 0.2 1.4e-14 54.4 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EKE40596.1 - 8.1e-14 51.8 0.0 2e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EKE40596.1 - 7.5e-09 35.6 0.4 1.5e-07 31.4 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EKE40596.1 - 0.0014 18.7 0.0 0.99 9.4 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EKE40596.1 - 0.0031 17.8 0.0 0.0086 16.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKE40596.1 - 0.0076 16.5 0.1 0.021 15.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EKE40596.1 - 0.0077 16.0 0.0 0.021 14.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EKE40596.1 - 0.014 15.4 0.0 0.044 13.7 0.0 1.8 2 0 0 2 2 2 0 Flavivirus DEAD domain T2SSE PF00437.20 EKE40596.1 - 0.021 13.9 0.1 0.072 12.1 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_14 PF13173.6 EKE40596.1 - 0.022 14.8 1.1 0.6 10.1 0.3 2.9 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.22 EKE40596.1 - 0.026 14.2 0.0 0.1 12.2 0.0 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain EMC1_C PF07774.13 EKE40598.1 - 2.3e-25 89.6 2.9 4.6e-25 88.6 2.9 1.5 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal RasGAP PF00616.19 EKE40599.1 - 0.0049 16.6 11.2 0.007 16.1 0.3 3.1 2 1 0 3 3 3 2 GTPase-activator protein for Ras-like GTPase TPR_MLP1_2 PF07926.12 EKE40599.1 - 0.11 12.5 4.2 0.23 11.5 4.2 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Esterase PF00756.20 EKE40601.1 - 4e-21 75.8 0.0 1.1e-20 74.4 0.0 1.7 1 1 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 EKE40601.1 - 0.00022 20.6 0.0 0.00052 19.4 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EKE40601.1 - 0.0093 15.5 0.0 0.019 14.5 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 EKE40601.1 - 0.087 12.3 0.0 0.19 11.2 0.0 1.5 1 1 0 1 1 1 0 Esterase PHB depolymerase MYT1 PF08474.11 EKE40603.1 - 0.054 13.4 0.2 0.1 12.5 0.2 1.4 1 0 0 1 1 1 0 Myelin transcription factor 1 Man-6-P_recep PF02157.15 EKE40604.1 - 3.1e-16 59.2 0.7 6.4e-16 58.2 0.7 1.5 1 1 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 EKE40604.1 - 5.4e-09 36.3 1.2 2.5e-08 34.1 1.2 2.0 1 1 0 1 1 1 1 Autophagy-related protein 27 DUF2721 PF11026.8 EKE40604.1 - 0.31 10.9 2.3 0.78 9.6 2.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF3139 PF11337.8 EKE40604.1 - 7.2 7.3 9.7 11 6.7 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Polysacc_deac_1 PF01522.21 EKE40605.1 - 8.3e-24 83.9 0.0 1.3e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Hpr_kinase_N PF02603.16 EKE40605.1 - 0.065 13.3 0.0 0.19 11.7 0.0 1.7 2 0 0 2 2 2 0 HPr Serine kinase N terminus DUF4215 PF13948.6 EKE40605.1 - 3.1 8.3 5.1 0.59 10.6 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4215) Antimicrobial19 PF08225.11 EKE40607.1 - 0.67 9.6 4.9 7.9 6.2 0.5 3.6 2 0 0 2 2 2 0 Pseudin antimicrobial peptide MDH PF02315.16 EKE40609.1 - 0.036 14.1 0.2 0.036 14.1 0.2 5.4 7 0 0 7 7 7 0 Methanol dehydrogenase beta subunit TLD PF07534.16 EKE40612.1 - 4.2e-05 23.8 3.7 4.8e-05 23.6 1.4 2.2 2 1 0 3 3 3 1 TLD DUF5401 PF17380.2 EKE40612.1 - 2.1 6.3 15.7 2.8 5.9 15.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) DUF4337 PF14235.6 EKE40612.1 - 5.5 7.1 7.4 9.6 6.3 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) TLD PF07534.16 EKE40613.1 - 0.00013 22.2 0.2 0.00039 20.7 0.1 1.9 1 1 1 2 2 2 1 TLD Linker_histone PF00538.19 EKE40616.1 - 0.0077 16.6 0.7 0.0077 16.6 0.7 2.6 3 1 1 4 4 4 1 linker histone H1 and H5 family DUF1810 PF08837.11 EKE40616.1 - 0.023 14.5 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1810) LETM1 PF07766.13 EKE40616.1 - 0.05 12.9 3.0 0.088 12.1 3.0 1.4 1 0 0 1 1 1 0 LETM1-like protein T2SSK PF03934.13 EKE40616.1 - 0.091 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K ATG11 PF10377.9 EKE40616.1 - 0.54 10.3 4.4 0.13 12.3 0.7 1.8 2 1 0 2 2 2 0 Autophagy-related protein 11 DUF4840 PF16128.5 EKE40616.1 - 6 6.9 10.8 3.8 7.5 5.4 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4840) zf-4CXXC_R1 PF10497.9 EKE40617.1 - 0.34 11.2 7.4 0.54 10.5 7.4 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 DB PF01682.19 EKE40617.1 - 1.4 9.2 12.1 1.6 9.0 6.5 2.2 1 1 1 2 2 2 0 DB module Zip PF02535.22 EKE40618.1 - 0.1 11.8 0.4 0.1 11.8 0.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter FAM176 PF14851.6 EKE40618.1 - 0.17 11.5 5.9 0.23 11.1 5.9 1.1 1 0 0 1 1 1 0 FAM176 family CobT PF06213.12 EKE40618.1 - 3.1 7.1 7.0 3.8 6.8 7.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 EKE40618.1 - 7.2 4.8 6.8 8.7 4.5 6.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 EKE40618.1 - 9.8 4.8 9.5 12 4.5 9.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PH PF00169.29 EKE40619.1 - 1.3e-09 38.5 1.4 2.7e-09 37.5 0.3 2.0 2 0 0 2 2 2 1 PH domain SPARC_Ca_bdg PF10591.9 EKE40619.1 - 0.00042 20.6 0.5 0.028 14.7 0.1 2.7 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region PH_3 PF14593.6 EKE40619.1 - 0.0024 18.0 0.4 0.011 15.8 0.1 2.3 2 1 0 2 2 2 1 PH domain PH_11 PF15413.6 EKE40619.1 - 0.055 13.9 0.2 0.055 13.9 0.2 2.2 2 1 0 2 2 2 0 Pleckstrin homology domain PH_8 PF15409.6 EKE40619.1 - 0.073 13.4 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain ANAPC10 PF03256.16 EKE40620.1 - 1.4e-37 129.2 0.0 1.6e-37 129.0 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 EKE40620.1 - 0.0037 17.4 0.0 0.0048 17.0 0.0 1.3 1 1 0 1 1 1 1 F5/8 type C domain XRCC1_N PF01834.16 EKE40620.1 - 0.03 14.3 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 XRCC1 N terminal domain FAE1_CUT1_RppA PF08392.12 EKE40621.1 - 2.1e-94 316.1 0.0 3.3e-94 315.4 0.0 1.2 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.10 EKE40621.1 - 4.8e-11 42.7 0.0 7.1e-10 38.9 0.0 2.3 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Chal_sti_synt_C PF02797.15 EKE40621.1 - 2e-07 31.1 0.0 3.8e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EKE40621.1 - 0.00074 19.0 0.0 0.0012 18.3 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III PF08545.10 EKE40621.1 - 0.0055 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF573 PF04504.14 EKE40622.1 - 0.00017 22.2 7.2 0.0002 21.9 4.6 2.0 1 1 1 2 2 2 1 Protein of unknown function, DUF573 Myb_DNA-bind_4 PF13837.6 EKE40622.1 - 0.00066 20.0 2.1 0.00066 20.0 2.1 1.7 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain DUF608 PF04685.13 EKE40622.1 - 0.013 14.6 0.9 0.016 14.4 0.5 1.3 1 1 0 1 1 1 0 Glycosyl-hydrolase family 116, catalytic region OprF PF05736.11 EKE40622.1 - 0.024 14.4 0.0 0.029 14.1 0.0 1.1 1 0 0 1 1 1 0 OprF membrane domain NOD PF06816.13 EKE40622.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 NOTCH protein Glyco_hydro_25 PF01183.20 EKE40623.1 - 1.2e-05 25.6 0.6 1.4e-05 25.4 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 DUF1906 PF08924.11 EKE40623.1 - 0.0067 16.6 1.2 0.02 15.1 1.3 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1906) MMR_HSR1_Xtn PF16897.5 EKE40624.1 - 1.5e-35 121.4 0.2 3.4e-35 120.3 0.2 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EKE40624.1 - 7.5e-20 71.1 0.1 2e-19 69.7 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 EKE40624.1 - 8.7e-16 57.7 0.0 1.8e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EKE40624.1 - 1e-08 34.9 0.0 3.2e-08 33.3 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EKE40624.1 - 0.0083 16.2 0.1 0.42 10.7 0.0 2.3 1 1 1 2 2 2 1 Dynamin family MeaB PF03308.16 EKE40624.1 - 0.013 14.5 0.3 0.09 11.7 0.1 2.3 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 EKE40624.1 - 0.017 15.3 0.3 7.2 6.9 0.1 2.6 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EKE40624.1 - 0.019 14.9 0.1 6.3 6.7 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase NOG1 PF06858.14 EKE40624.1 - 0.042 13.6 0.7 7.2 6.5 0.1 3.4 3 0 0 3 3 3 0 Nucleolar GTP-binding protein 1 (NOG1) SET PF00856.28 EKE40626.1 - 5.4e-15 56.2 0.5 2.4e-14 54.1 0.2 2.2 2 1 0 2 2 2 1 SET domain Myb_DNA-binding PF00249.31 EKE40627.1 - 2e-29 101.5 1.2 1.2e-15 57.4 0.3 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE40627.1 - 3.4e-24 84.8 0.1 1.5e-13 50.8 0.0 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EKE40627.1 - 0.00046 20.2 0.0 0.064 13.3 0.0 2.4 1 1 1 2 2 2 2 SLIDE SANT_DAMP1_like PF16282.5 EKE40627.1 - 0.0012 19.0 0.0 1.3 9.3 0.0 2.2 1 1 1 2 2 2 2 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 EKE40627.1 - 0.0012 18.7 0.0 0.052 13.5 0.0 2.1 2 0 0 2 2 2 1 Myb DNA-binding like PP2C PF00481.21 EKE40628.1 - 1e-25 90.9 0.1 1.3e-25 90.5 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE40628.1 - 0.00017 21.3 0.0 0.00031 20.4 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C zf-CDGSH PF09360.10 EKE40628.1 - 0.14 12.4 0.1 2.4 8.4 0.0 2.8 3 0 0 3 3 3 0 Iron-binding zinc finger CDGSH type PTH2 PF01981.16 EKE40629.1 - 5.9e-36 123.3 0.0 6.4e-36 123.2 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DMP12 PF16779.5 EKE40629.1 - 0.019 14.9 0.1 0.022 14.8 0.1 1.2 1 0 0 1 1 1 0 DNA-mimic protein PRA1 PF03208.19 EKE40630.1 - 0.00025 20.7 4.3 0.00032 20.3 4.3 1.1 1 0 0 1 1 1 1 PRA1 family protein YwiC PF14256.6 EKE40630.1 - 0.063 13.6 2.8 0.13 12.6 2.8 1.4 1 1 0 1 1 1 0 YwiC-like protein RseC_MucC PF04246.12 EKE40630.1 - 0.092 12.7 0.4 0.092 12.7 0.4 2.1 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Nbas_N PF15492.6 EKE40630.1 - 0.12 11.7 0.4 0.14 11.4 0.4 1.2 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal DUF846 PF05832.12 EKE40630.1 - 0.43 10.6 7.8 0.47 10.5 0.8 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF846) DUF4870 PF09685.10 EKE40630.1 - 2.2 8.4 12.1 28 4.9 12.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4870) Drf_FH3 PF06367.16 EKE40631.1 - 0.0061 16.2 0.9 0.014 15.0 0.7 1.8 1 1 0 1 1 1 1 Diaphanous FH3 Domain HipN PF18253.1 EKE40631.1 - 0.12 12.1 0.2 0.43 10.3 0.1 2.0 2 0 0 2 2 2 0 Hsp70-interacting protein N N-terminal domain PP2C PF00481.21 EKE40632.1 - 1e-29 104.0 0.1 1.4e-29 103.5 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C UEV PF05743.13 EKE40633.1 - 1e-10 41.5 1.6 2e-10 40.5 0.1 2.3 2 1 0 2 2 2 1 UEV domain Vps23_core PF09454.10 EKE40633.1 - 0.0075 16.2 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 Vps23 core domain UPF0489 PF12640.7 EKE40633.1 - 2.5 8.3 8.7 0.43 10.8 3.1 2.3 1 1 1 2 2 2 0 UPF0489 domain Aa_trans PF01490.18 EKE40634.1 - 3.2e-19 69.0 29.1 1e-18 67.3 29.1 1.9 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Zip PF02535.22 EKE40634.1 - 2.4 7.3 7.7 0.27 10.4 1.5 2.5 2 0 0 2 2 2 0 ZIP Zinc transporter DNA_topoisoIV PF00521.20 EKE40635.1 - 0.024 13.6 3.8 0.033 13.1 3.8 1.2 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A DUF2448 PF10476.9 EKE40636.1 - 1.7 8.5 3.8 1 9.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2448) DUF4407 PF14362.6 EKE40636.1 - 4.6 6.5 11.1 9.7 5.4 11.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Metallophos PF00149.28 EKE40639.1 - 6.6e-13 49.6 2.0 6.6e-13 49.6 2.0 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase LPD28 PF18843.1 EKE40640.1 - 0.097 12.3 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 Large polyvalent protein associated domain 28 RTC_insert PF05189.13 EKE40642.1 - 1.1 9.8 8.0 26 5.4 0.2 3.7 2 1 0 2 2 2 0 RNA 3'-terminal phosphate cyclase (RTC), insert domain TIG PF01833.24 EKE40644.1 - 6.4e-09 35.8 2.7 3e-06 27.2 0.3 2.6 2 0 0 2 2 2 2 IPT/TIG domain Siva PF05458.12 EKE40644.1 - 0.28 10.8 8.2 0.054 13.2 4.4 1.7 2 0 0 2 2 2 0 Cd27 binding protein (Siva) FYVE PF01363.21 EKE40644.1 - 0.92 9.7 12.4 0.49 10.6 9.1 2.1 2 0 0 2 2 2 0 FYVE zinc finger Pam16 PF03656.13 EKE40644.1 - 4.9 7.2 8.2 0.29 11.2 1.2 2.4 2 0 0 2 2 2 0 Pam16 DUF4064 PF13273.6 EKE40645.1 - 0.05 13.9 0.3 0.05 13.9 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) SKA2 PF16740.5 EKE40645.1 - 0.14 11.9 0.2 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF2439 PF10382.9 EKE40646.1 - 5.9e-07 29.7 0.8 1.7e-06 28.2 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) DUF4276 PF14103.6 EKE40646.1 - 0.056 13.7 0.4 0.056 13.7 0.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4276) dNK PF01712.19 EKE40647.1 - 0.02 14.8 0.3 0.033 14.0 0.3 1.6 1 1 0 1 1 1 0 Deoxynucleoside kinase 2_5_RNA_ligase2 PF13563.6 EKE40647.1 - 0.2 11.6 0.0 0.43 10.5 0.0 1.4 1 1 0 1 1 1 0 2'-5' RNA ligase superfamily Cytokin_check_N PF10407.9 EKE40647.1 - 0.31 11.0 3.2 3.5 7.7 0.3 3.3 3 1 1 4 4 4 0 Cdc14 phosphatase binding protein N-terminus B-block_TFIIIC PF04182.12 EKE40648.1 - 6.8e-12 45.4 2.7 1.1e-11 44.7 0.1 2.8 3 0 0 3 3 3 1 B-block binding subunit of TFIIIC MarR PF01047.22 EKE40648.1 - 5.7e-05 23.0 0.2 0.0016 18.3 0.0 3.1 3 0 0 3 3 3 1 MarR family MarR_2 PF12802.7 EKE40648.1 - 0.0052 16.6 0.0 0.22 11.4 0.0 3.3 3 1 0 3 3 3 1 MarR family HTH_24 PF13412.6 EKE40648.1 - 0.019 14.5 2.8 0.025 14.1 0.1 2.9 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding Suv3_N PF18114.1 EKE40648.1 - 0.058 13.5 1.4 0.61 10.2 0.0 3.4 3 0 0 3 3 3 0 Suv3 helical N-terminal domain HTH_27 PF13463.6 EKE40648.1 - 0.14 12.7 0.1 1.4 9.5 0.0 2.6 3 0 0 3 3 3 0 Winged helix DNA-binding domain LRR_5 PF13306.6 EKE40649.1 - 8.2e-199 649.8 149.7 1.2e-29 102.9 17.8 9.6 5 3 4 9 9 9 9 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE40649.1 - 3.7e-35 119.5 0.3 0.00084 19.1 0.0 14.8 9 4 4 13 13 13 12 Leucine rich repeat EMC3_TMCO1 PF01956.16 EKE40650.1 - 3.1e-24 85.6 1.9 3.8e-24 85.3 1.9 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like EBA-175_VI PF11556.8 EKE40650.1 - 0.013 15.8 0.2 0.024 15.0 0.2 1.4 1 0 0 1 1 1 0 Erythrocyte binding antigen 175 FlxA PF14282.6 EKE40650.1 - 0.036 14.0 1.1 0.053 13.5 1.1 1.1 1 0 0 1 1 1 0 FlxA-like protein ATG11 PF10377.9 EKE40650.1 - 0.04 14.0 0.1 0.06 13.4 0.1 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 CVNH PF08881.10 EKE40651.1 - 0.013 16.2 0.0 0.3 11.8 0.0 3.0 1 1 1 2 2 2 0 CVNH domain COG4 PF08318.12 EKE40652.1 - 9.8e-16 57.7 13.3 4.6e-13 49.0 13.3 2.2 1 1 0 1 1 1 1 COG4 transport protein DUF3450 PF11932.8 EKE40652.1 - 0.86 8.9 4.5 2.6 7.3 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EKE40652.1 - 0.89 9.6 4.5 0.87 9.6 1.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) CitMHS PF03600.16 EKE40653.1 - 4.3e-22 78.7 19.4 4.3e-22 78.7 19.4 2.5 1 1 1 2 2 2 2 Citrate transporter TrkA_C PF02080.21 EKE40653.1 - 1.9e-05 24.4 0.0 0.27 11.1 0.0 2.5 2 0 0 2 2 2 2 TrkA-C domain RTC PF01137.21 EKE40654.1 - 5.5e-62 208.9 0.0 6.2e-62 208.7 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RRM_1 PF00076.22 EKE40655.1 - 8.9e-18 63.9 0.2 2.2e-09 37.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE40655.1 - 0.00054 19.9 0.2 0.013 15.5 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EKE40655.1 - 0.00068 19.2 0.1 0.0029 17.2 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.12 EKE40655.1 - 0.013 15.3 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Calcipressin RRM_occluded PF16842.5 EKE40655.1 - 0.04 13.8 0.0 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Occluded RNA-recognition motif Ras PF00071.22 EKE40656.1 - 1.4e-46 158.0 0.5 1.7e-46 157.8 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40656.1 - 6.2e-28 97.4 0.1 8.8e-28 96.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40656.1 - 8.7e-15 54.6 0.5 1.2e-14 54.2 0.5 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE40656.1 - 1e-10 41.4 0.2 1.6e-10 40.7 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EKE40656.1 - 1.7e-06 27.6 0.4 2e-06 27.3 0.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE40656.1 - 9.7e-06 25.6 0.1 2.1e-05 24.6 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE40656.1 - 0.00029 20.8 0.2 0.37 10.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EKE40656.1 - 0.0038 16.8 0.5 0.46 10.0 0.1 2.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EKE40656.1 - 0.019 14.7 0.3 0.062 13.0 0.3 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EKE40656.1 - 0.032 14.0 0.0 0.097 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EKE40656.1 - 0.047 13.2 0.1 0.17 11.4 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region G-alpha PF00503.20 EKE40656.1 - 0.052 12.7 2.7 0.15 11.2 0.5 2.5 1 1 1 2 2 2 0 G-protein alpha subunit AAA_22 PF13401.6 EKE40656.1 - 0.15 12.3 0.0 4.6 7.5 0.0 2.5 1 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EKE40656.1 - 0.2 12.0 0.0 0.23 11.9 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain TK PF00265.18 EKE40657.1 - 7.2e-62 208.4 0.1 8.5e-62 208.1 0.1 1.0 1 0 0 1 1 1 1 Thymidine kinase AAA_14 PF13173.6 EKE40657.1 - 0.011 15.8 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EKE40657.1 - 0.055 13.4 0.0 0.07 13.0 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Herpes_ori_bp PF02399.15 EKE40657.1 - 0.065 11.3 0.0 0.1 10.6 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein SPEG_u2 PF16650.5 EKE40657.1 - 0.19 11.9 0.1 0.79 10.0 0.1 1.9 2 0 0 2 2 2 0 Unstructured region on SPEG complex protein DUF676 PF05057.14 EKE40658.1 - 1.3e-20 73.8 0.0 3.4e-20 72.5 0.0 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EKE40658.1 - 2.1e-05 24.5 0.0 3.1e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 EKE40658.1 - 0.0011 18.8 0.0 0.0022 17.8 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 EKE40658.1 - 0.13 12.0 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_6 PF12697.7 EKE40658.1 - 0.14 12.8 0.0 0.19 12.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ras PF00071.22 EKE40659.1 - 4.7e-41 140.1 0.2 5.8e-41 139.8 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40659.1 - 4e-28 98.0 0.0 5.9e-28 97.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40659.1 - 2.6e-11 43.3 0.1 3.4e-11 42.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE40659.1 - 1.2e-05 25.3 0.0 1.9e-05 24.7 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EKE40659.1 - 0.00011 22.2 0.1 0.00019 21.4 0.1 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Gtr1_RagA PF04670.12 EKE40659.1 - 0.00014 21.3 0.1 0.00018 20.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF445 PF04286.12 EKE40659.1 - 0.023 14.5 0.1 0.026 14.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) SRPRB PF09439.10 EKE40659.1 - 0.036 13.5 0.0 0.053 12.9 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 EKE40659.1 - 0.047 13.0 0.1 5.1 6.3 0.1 2.2 2 0 0 2 2 2 0 Septin AAA_16 PF13191.6 EKE40659.1 - 0.072 13.5 0.0 0.13 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EKE40659.1 - 0.088 12.5 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EKE40659.1 - 0.11 12.4 0.1 0.96 9.3 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 EKE40659.1 - 0.16 12.3 0.1 0.5 10.6 0.0 1.8 2 1 1 3 3 3 0 AAA domain DEAD PF00270.29 EKE40660.1 - 8.7e-41 139.6 2.6 2.2e-40 138.3 0.2 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE40660.1 - 6.9e-25 87.6 0.0 6.9e-25 87.6 0.0 4.5 6 0 0 6 6 6 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE40660.1 - 1.6e-08 34.8 0.0 1.6e-08 34.8 0.0 3.4 3 1 0 4 4 4 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EKE40660.1 - 0.0006 20.1 0.2 0.0044 17.3 0.2 2.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKE40660.1 - 0.0032 17.8 0.1 0.012 16.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain IL31 PF15209.6 EKE40660.1 - 0.3 10.9 4.7 2.7 7.8 0.1 3.3 3 0 0 3 3 3 0 Interleukin 31 DSPc PF00782.20 EKE40661.1 - 6.5e-20 71.3 0.3 6.5e-20 71.3 0.3 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Myotub-related PF06602.14 EKE40661.1 - 0.0053 15.7 0.1 0.0097 14.9 0.0 1.5 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain LCAT PF02450.15 EKE40662.1 - 9.8e-42 143.5 0.8 4.3e-40 138.1 0.1 2.0 1 1 0 2 2 2 2 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EKE40662.1 - 6.6e-06 25.8 0.1 1.8e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EKE40662.1 - 1.1e-05 25.2 0.0 0.0001 22.1 0.0 2.1 2 0 0 2 2 2 1 PGAP1-like protein Hydrolase_4 PF12146.8 EKE40662.1 - 0.024 13.9 0.0 0.096 11.9 0.0 1.8 1 1 1 2 2 2 0 Serine aminopeptidase, S33 DUF915 PF06028.11 EKE40662.1 - 0.058 12.7 0.5 0.53 9.6 0.1 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 EKE40662.1 - 0.091 13.3 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family TBP PF00352.21 EKE40663.1 - 1.6e-58 194.6 0.7 1.1e-28 99.0 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EKE40663.1 - 3.1e-05 24.0 0.0 0.0078 16.3 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Kelch_5 PF13854.6 EKE40663.1 - 0.042 13.9 0.0 14 5.8 0.0 2.3 2 0 0 2 2 2 0 Kelch motif Peptidase_C71 PF12386.8 EKE40663.1 - 0.054 13.1 0.1 0.12 12.0 0.1 1.5 1 1 0 1 1 1 0 Pseudomurein endo-isopeptidase Pei Prenyltrans PF00432.21 EKE40664.1 - 6e-14 51.5 4.4 0.00026 20.6 0.0 6.0 6 0 0 6 6 6 4 Prenyltransferase and squalene oxidase repeat NUDIX_2 PF13869.6 EKE40665.1 - 2.3e-65 219.7 3.7 2.3e-65 219.7 3.7 1.4 2 0 0 2 2 2 1 Nucleotide hydrolase NapB PF03892.14 EKE40665.1 - 0.59 10.1 3.4 1.3 9.0 3.4 1.7 1 0 0 1 1 1 0 Nitrate reductase cytochrome c-type subunit (NapB) Mt_ATP-synt_B PF05405.14 EKE40666.1 - 0.0025 17.4 0.9 0.021 14.4 0.8 2.4 2 0 0 2 2 2 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Terminase_4 PF05119.12 EKE40666.1 - 0.025 15.0 0.3 2.7 8.5 0.0 2.8 2 1 0 2 2 2 0 Phage terminase, small subunit IL3 PF02059.15 EKE40666.1 - 0.052 13.6 5.9 0.38 10.8 0.2 2.9 2 1 0 2 2 2 0 Interleukin-3 Focal_AT PF03623.13 EKE40666.1 - 0.76 9.8 11.9 11 6.0 0.3 4.4 3 1 1 5 5 5 0 Focal adhesion targeting region DUF5446 PF17522.2 EKE40667.1 - 3.4 7.9 14.9 1.5 9.0 0.7 5.5 4 0 0 4 4 4 0 Family of unknown function (DUF5446) Hat1_N PF10394.9 EKE40668.1 - 1.4e-29 103.4 3.3 2.6e-29 102.5 3.3 1.5 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 EKE40668.1 - 0.052 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EKE40668.1 - 0.072 13.5 0.0 0.28 11.6 0.0 2.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pox_D5 PF03288.16 EKE40668.1 - 0.23 11.9 2.8 8 7.0 0.5 3.0 2 1 0 2 2 2 0 Poxvirus D5 protein-like LRR_4 PF12799.7 EKE40669.1 - 2.1e-12 47.0 28.6 0.00014 22.1 1.6 5.9 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE40669.1 - 2.4e-11 43.2 27.8 8.7e-05 22.2 0.0 5.8 4 2 2 6 6 6 4 Leucine rich repeat GILT PF03227.16 EKE40669.1 - 1.4e-07 31.8 0.0 3.2e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) LRRNT_2 PF08263.12 EKE40669.1 - 4.9e-06 26.7 0.3 1e-05 25.7 0.3 1.6 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain DUF1699 PF08004.11 EKE40669.1 - 0.00011 21.9 0.0 0.00036 20.2 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1699) LRR_6 PF13516.6 EKE40669.1 - 0.0044 17.0 12.5 0.45 10.7 0.3 5.6 5 0 0 5 5 5 2 Leucine Rich repeat LRR_9 PF14580.6 EKE40669.1 - 0.067 12.7 2.8 0.81 9.2 2.9 2.3 1 1 1 2 2 2 0 Leucine-rich repeat LRR_1 PF00560.33 EKE40669.1 - 0.31 11.7 25.6 2.4 9.0 0.3 7.5 7 1 1 8 8 8 0 Leucine Rich Repeat DHHC PF01529.20 EKE40670.1 - 9.2e-31 106.7 11.5 9.2e-31 106.7 11.5 3.0 3 0 0 3 3 3 1 DHHC palmitoyltransferase UPF0242 PF06785.11 EKE40670.1 - 0.0023 18.0 1.5 0.0031 17.6 1.5 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF4834 PF16118.5 EKE40670.1 - 0.012 16.5 1.7 0.012 16.5 1.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF5526 PF17664.1 EKE40670.1 - 0.44 10.1 5.9 0.64 9.6 5.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5526) Ribosomal_S8 PF00410.19 EKE40671.1 - 1.6e-11 44.3 0.1 1.8e-11 44.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S8 FlgI PF02119.16 EKE40671.1 - 0.07 12.1 0.3 0.078 11.9 0.3 1.1 1 0 0 1 1 1 0 Flagellar P-ring protein UNC-93 PF05978.16 EKE40672.1 - 4.6e-16 58.9 11.3 4.6e-16 58.9 11.3 4.1 2 1 1 5 5 5 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 EKE40672.1 - 4.2e-05 22.6 58.8 0.00075 18.5 33.6 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1689 PF07954.11 EKE40672.1 - 0.41 11.1 1.8 0.51 10.7 0.2 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1689) Vps53_N PF04100.12 EKE40673.1 - 2.3e-31 109.1 9.9 2.3e-31 109.1 9.9 1.9 2 0 0 2 2 2 1 Vps53-like, N-terminal CRISPR_Cas2 PF09827.9 EKE40673.1 - 0.098 12.9 1.5 0.31 11.2 0.3 2.5 2 0 0 2 2 2 0 CRISPR associated protein Cas2 DUF5012 PF16404.5 EKE40673.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5012) ATP-synt_F PF01990.17 EKE40675.1 - 0.093 13.1 0.5 0.17 12.2 0.5 1.4 1 0 0 1 1 1 0 ATP synthase (F/14-kDa) subunit tRNA-synt_2c PF01411.19 EKE40678.1 - 4.9e-57 193.7 0.2 1.6e-28 99.6 0.0 3.6 3 1 1 4 4 4 3 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EKE40678.1 - 3.8e-12 46.1 2.6 3.8e-12 46.1 2.6 2.4 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain TDRP PF15683.5 EKE40678.1 - 0.046 13.7 3.2 0.12 12.4 3.2 1.6 1 0 0 1 1 1 0 Testis development-related protein PcfK PF14058.6 EKE40678.1 - 1 9.6 6.5 0.41 10.9 2.6 2.2 2 0 0 2 2 2 0 PcfK-like protein CTP_transf_like PF01467.26 EKE40679.1 - 4.6e-11 43.1 0.2 7.3e-11 42.4 0.2 1.3 1 1 0 1 1 1 1 Cytidylyltransferase-like Pkinase PF00069.25 EKE40680.1 - 1.6e-15 57.2 0.1 1.8e-15 57.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EKE40680.1 - 3e-05 23.5 0.1 4.5e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 EKE40680.1 - 0.00041 19.7 0.0 0.00053 19.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE40680.1 - 0.00061 18.7 0.1 0.00091 18.1 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKE40680.1 - 0.0021 18.0 0.0 0.0039 17.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EKE40680.1 - 0.0051 16.4 0.3 0.014 15.0 0.1 1.8 2 0 0 2 2 2 1 RIO1 family PIP49_C PF12260.8 EKE40680.1 - 0.0094 15.6 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Kdo PF06293.14 EKE40680.1 - 0.2 11.0 0.1 0.3 10.4 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CYTL1 PF15153.6 EKE40682.1 - 0.017 15.1 0.7 6.7 6.7 0.2 2.7 2 0 0 2 2 2 0 Cytokine-like protein 1 HTH_Tnp_Tc3_2 PF01498.18 EKE40682.1 - 0.043 14.1 0.4 0.15 12.3 0.4 1.9 1 0 0 1 1 1 0 Transposase SNCAIP_SNCA_bd PF16700.5 EKE40682.1 - 5.1 6.9 9.7 0.42 10.4 3.9 2.2 2 0 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain DUF2157 PF09925.9 EKE40683.1 - 2.4 8.0 13.8 3.1 7.6 4.3 3.1 2 1 1 3 3 3 0 Predicted membrane protein (DUF2157) LRR_5 PF13306.6 EKE40684.1 - 8.9e-07 28.9 17.1 0.018 15.0 0.8 5.1 3 1 2 5 5 5 3 BspA type Leucine rich repeat region (6 copies) FNIP PF05725.12 EKE40684.1 - 0.1 12.8 20.4 4.1 7.7 0.1 7.1 7 1 0 7 7 7 0 FNIP Repeat Pkinase_Tyr PF07714.17 EKE40685.1 - 1.5e-55 188.2 0.0 2.3e-55 187.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40685.1 - 1.5e-37 129.4 0.0 7.1e-37 127.2 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Kelch_6 PF13964.6 EKE40685.1 - 1.8e-21 75.6 12.0 3e-05 24.1 0.2 6.7 7 0 0 7 7 7 4 Kelch motif Kelch_1 PF01344.25 EKE40685.1 - 7.3e-16 57.5 17.0 6.9e-06 25.5 0.9 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EKE40685.1 - 1.2e-14 53.6 7.0 0.0045 16.9 1.0 5.0 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 EKE40685.1 - 3.5e-14 52.5 7.1 0.035 14.1 0.0 5.6 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EKE40685.1 - 5.1e-12 45.5 16.9 0.017 15.1 0.7 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EKE40685.1 - 1.8e-10 40.9 0.8 0.043 14.1 0.0 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain PPDK_N PF01326.19 EKE40685.1 - 0.014 14.7 0.1 0.022 14.1 0.1 1.2 1 0 0 1 1 1 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain Pkinase_Tyr PF07714.17 EKE40686.1 - 1.1e-66 224.7 0.1 2.9e-60 203.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EKE40686.1 - 7.7e-38 130.4 0.0 1.6e-37 129.3 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Kelch_1 PF01344.25 EKE40686.1 - 5.2e-22 77.2 4.8 6e-05 22.5 0.4 5.7 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 EKE40686.1 - 4.1e-15 55.4 7.4 0.00064 19.9 0.1 6.0 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EKE40686.1 - 6.4e-15 54.9 4.1 3.2e-06 27.0 0.1 5.7 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EKE40686.1 - 5.9e-13 48.5 4.7 2.7e-05 24.0 0.4 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 EKE40686.1 - 1.4e-09 37.9 1.1 0.035 14.4 0.0 5.3 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EKE40686.1 - 0.008 16.1 8.4 15 5.7 0.0 5.6 6 0 0 6 6 6 2 Kelch motif Pkinase_fungal PF17667.1 EKE40686.1 - 0.087 11.6 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Dus PF01207.17 EKE40687.1 - 1.5e-46 158.9 1.0 1.8e-46 158.7 0.0 1.5 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) zf-CCCH PF00642.24 EKE40687.1 - 0.0003 20.6 14.1 0.00089 19.1 0.4 3.0 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DHO_dh PF01180.21 EKE40687.1 - 0.046 12.9 0.1 0.25 10.5 0.1 2.0 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase NanE PF04131.14 EKE40687.1 - 0.15 11.3 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase CCDC-167 PF15188.6 EKE40687.1 - 0.17 12.2 3.7 0.48 10.8 3.7 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Torus PF16131.5 EKE40687.1 - 0.37 11.5 8.2 0.54 11.0 1.8 2.5 1 1 1 2 2 2 0 Torus domain G-alpha PF00503.20 EKE40688.1 - 1e-95 320.9 0.1 2e-95 320.0 0.1 1.4 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EKE40688.1 - 6.6e-14 51.7 0.6 4e-11 42.7 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EKE40688.1 - 0.00016 21.8 1.0 0.66 10.2 0.0 2.6 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EKE40688.1 - 0.00027 20.4 1.3 0.031 13.6 0.2 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE40688.1 - 0.0059 16.2 0.4 0.13 11.8 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE40688.1 - 0.089 12.9 0.5 7.1 6.7 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase PC_rep PF01851.22 EKE40690.1 - 2.9e-25 87.3 30.1 1.7e-07 31.3 0.1 10.2 11 0 0 11 11 11 5 Proteasome/cyclosome repeat RPN2_C PF18004.1 EKE40690.1 - 9.8e-16 58.1 6.3 3.8e-15 56.2 0.9 2.8 2 1 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain HEAT_2 PF13646.6 EKE40690.1 - 1.6e-15 57.3 0.1 1.9e-12 47.4 0.0 2.7 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 EKE40690.1 - 9.7e-07 29.2 0.1 0.00022 21.6 0.0 3.2 2 0 0 2 2 2 1 HEAT-like repeat HEAT PF02985.22 EKE40690.1 - 0.00021 21.3 0.0 1.5 9.2 0.0 3.8 3 0 0 3 3 3 1 HEAT repeat DNA_alkylation PF08713.11 EKE40690.1 - 0.0012 18.6 0.0 0.0092 15.7 0.0 2.2 2 0 0 2 2 2 1 DNA alkylation repair enzyme DUF3052 PF11253.8 EKE40690.1 - 0.1 12.5 0.0 0.39 10.6 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) Cnd1 PF12717.7 EKE40690.1 - 0.11 12.6 6.7 0.32 11.0 0.0 3.6 2 2 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 TipAS PF07739.13 EKE40690.1 - 0.15 12.6 3.2 0.2 12.2 1.0 2.5 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain TPR_8 PF13181.6 EKE40690.1 - 0.33 11.3 4.1 2.6 8.5 1.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1878 PF08963.10 EKE40690.1 - 0.39 11.2 6.1 0.24 11.9 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1878) SAC3_GANP PF03399.16 EKE40691.1 - 1.3e-22 80.6 2.1 1.5e-21 77.0 2.1 2.1 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EKE40691.1 - 0.0014 18.6 0.1 0.0051 16.8 0.0 2.0 1 1 1 2 2 2 1 CSN8/PSMD8/EIF3K family OmpH PF03938.14 EKE40691.1 - 6.4 7.1 12.7 3.3e+02 1.5 12.8 2.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Peptidase_S9 PF00326.21 EKE40692.1 - 5.8e-53 179.5 0.5 5.8e-53 179.5 0.5 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 EKE40692.1 - 0.00013 20.9 0.2 0.003 16.5 0.0 2.6 3 0 0 3 3 3 1 Chlorophyllase enzyme Peptidase_S15 PF02129.18 EKE40692.1 - 0.00015 21.5 0.8 0.0027 17.3 0.4 2.5 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EKE40692.1 - 0.0055 16.4 0.0 1.3 8.6 0.0 2.3 2 0 0 2 2 2 2 Putative esterase PD40 PF07676.12 EKE40692.1 - 0.0063 16.4 0.1 1.5 8.9 0.1 2.7 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Abhydrolase_1 PF00561.20 EKE40692.1 - 0.015 14.9 1.1 0.056 13.1 0.6 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold PAF-AH_p_II PF03403.13 EKE40692.1 - 0.11 11.0 0.1 11 4.5 0.0 2.1 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II ArfGap PF01412.18 EKE40693.1 - 3.1e-30 104.7 1.3 5.6e-30 103.8 0.0 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 EKE40693.1 - 0.067 13.4 0.2 0.067 13.4 0.2 2.3 3 0 0 3 3 3 0 B-box zinc finger zf-Sec23_Sec24 PF04810.15 EKE40693.1 - 0.097 12.7 0.6 0.24 11.5 0.6 1.6 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger MCR_C PF04609.12 EKE40695.1 - 0.051 12.7 0.4 0.057 12.5 0.4 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C Cpn60_TCP1 PF00118.24 EKE40697.1 - 1.3e-153 512.1 15.3 1.5e-153 512.0 15.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TraH_2 PF06871.11 EKE40697.1 - 0.036 13.7 0.0 0.072 12.7 0.0 1.4 1 0 0 1 1 1 0 TraH_2 Phage_TAC_8 PF10666.9 EKE40697.1 - 0.2 11.9 2.3 6.1 7.1 0.1 3.1 3 0 0 3 3 3 0 Phage tail assembly chaperone protein Gp14 ()A118 WD40 PF00400.32 EKE40698.1 - 1.9e-31 107.6 14.4 1.3e-05 25.9 0.0 11.2 11 0 0 11 11 11 6 WD domain, G-beta repeat Utp12 PF04003.12 EKE40698.1 - 4.5e-13 49.4 1.2 8.8e-13 48.5 1.2 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EKE40698.1 - 1.9e-10 40.9 0.4 0.067 13.5 0.0 5.4 5 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EKE40698.1 - 8.8e-05 22.0 8.1 0.017 14.5 0.3 3.7 4 0 0 4 4 4 2 WD40-like domain Nup160 PF11715.8 EKE40698.1 - 9e-05 21.3 0.3 0.28 9.8 0.0 4.2 3 1 1 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EKE40698.1 - 0.021 14.7 0.1 0.69 9.8 0.0 3.3 5 1 0 5 5 5 0 Eukaryotic translation initiation factor eIF2A BLI1 PF17324.2 EKE40699.1 - 0.08 13.6 7.2 0.067 13.9 2.1 2.3 1 1 1 2 2 2 0 BLOC-1 interactor 1 Ras PF00071.22 EKE40700.1 - 5.5e-57 191.9 0.0 6.7e-57 191.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40700.1 - 2.3e-32 111.7 0.0 3.7e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40700.1 - 2.8e-12 46.4 0.0 3.5e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE40700.1 - 5.1e-05 22.9 0.0 0.00037 20.1 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE40700.1 - 0.00019 21.5 0.0 0.00035 20.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE40700.1 - 0.098 12.6 0.0 7.5 6.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Ldh_1_N PF00056.23 EKE40701.1 - 8e-35 120.0 0.2 1.1e-34 119.5 0.2 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EKE40701.1 - 2.3e-25 89.5 0.0 3.9e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain LRR_6 PF13516.6 EKE40702.1 - 4e-13 48.3 4.9 0.0057 16.6 0.1 7.8 8 0 0 8 8 8 3 Leucine Rich repeat RasGAP PF00616.19 EKE40702.1 - 0.054 13.2 5.1 0.059 13.1 1.8 2.4 1 1 1 2 2 2 0 GTPase-activator protein for Ras-like GTPase MRG PF05712.13 EKE40703.1 - 2.6e-22 79.1 4.9 8.8e-22 77.4 4.9 1.7 1 1 0 1 1 1 1 MRG zf_Hakai PF18408.1 EKE40703.1 - 0.14 11.9 2.9 0.31 10.8 2.9 1.6 1 0 0 1 1 1 0 C2H2 Hakai zinc finger domain zf-C2H2_4 PF13894.6 EKE40703.1 - 1.3 10.1 8.3 0.53 11.3 2.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger U1snRNP70_N PF12220.8 EKE40705.1 - 1.1e-11 45.2 0.1 1.4e-11 44.9 0.1 1.1 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal TPR_19 PF14559.6 EKE40706.1 - 7.7e-08 32.7 4.0 0.00095 19.6 0.3 3.0 2 1 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE40706.1 - 0.00033 20.8 0.1 0.0032 17.7 0.1 2.4 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 EKE40706.1 - 0.00044 19.9 0.3 0.046 13.4 0.0 2.2 1 1 1 2 2 2 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_8 PF13181.6 EKE40706.1 - 0.0006 19.8 2.8 1.7 9.1 0.2 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EKE40706.1 - 0.0013 19.3 0.2 1 10.4 0.1 3.2 1 1 3 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EKE40706.1 - 0.0014 18.6 0.9 2.6 8.4 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat R-HINP1I PF11463.8 EKE40706.1 - 0.0073 15.8 2.0 1.1 8.6 0.0 2.6 1 1 2 3 3 3 2 R.HinP1I restriction endonuclease TPR_21 PF09976.9 EKE40706.1 - 0.012 15.3 0.5 2.9 7.5 0.1 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 EKE40706.1 - 0.013 15.8 0.4 4 7.8 0.1 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EKE40706.1 - 0.023 15.3 3.6 16 6.4 0.1 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EKE40706.1 - 0.025 14.0 1.1 0.5 9.7 0.2 2.0 1 1 1 2 2 2 0 MalT-like TPR region Wzy_C_2 PF11846.8 EKE40706.1 - 0.042 13.8 0.2 0.14 12.1 0.1 1.9 1 1 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal TPR_12 PF13424.6 EKE40706.1 - 0.1 12.9 2.5 4.9 7.5 0.4 3.2 3 1 0 3 3 2 0 Tetratricopeptide repeat CbiG_C PF01890.16 EKE40706.1 - 0.11 13.1 0.3 13 6.4 0.3 2.5 2 1 0 2 2 2 0 Cobalamin synthesis G C-terminus zf-RING_2 PF13639.6 EKE40707.1 - 3.1e-08 33.8 14.9 3.1e-08 33.8 14.9 3.0 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKE40707.1 - 6.3e-08 32.3 15.6 6.3e-08 32.3 15.6 3.0 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EKE40707.1 - 2.5e-07 30.5 14.2 2.5e-07 30.5 14.2 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE40707.1 - 5.8e-06 26.1 17.3 5.8e-06 26.1 17.3 3.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE40707.1 - 1.7e-05 24.6 11.8 1.7e-05 24.6 11.8 2.8 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EKE40707.1 - 3.1e-05 23.8 16.0 3.1e-05 23.8 16.0 3.1 2 1 1 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EKE40707.1 - 0.00058 19.8 11.5 0.00058 19.8 11.5 2.5 2 0 0 2 2 2 1 RING-type zinc-finger PAD PF03068.15 EKE40707.1 - 0.059 12.4 0.2 0.069 12.1 0.2 1.2 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) Arm-DNA-bind_5 PF17293.2 EKE40707.1 - 0.093 13.2 2.5 0.22 12.0 0.3 2.1 2 0 0 2 2 2 0 Arm DNA-binding domain Metallophos PF00149.28 EKE40708.1 - 2.6e-33 116.2 0.1 4.3e-33 115.5 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EKE40708.1 - 0.00015 21.9 0.0 0.00032 20.9 0.0 1.5 1 0 0 1 1 1 1 PPP5 TPR repeat region Metallophos_2 PF12850.7 EKE40708.1 - 0.061 13.5 0.0 0.092 12.9 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain LRR_8 PF13855.6 EKE40709.1 - 7.7e-12 44.8 13.5 2.3e-07 30.5 0.0 4.3 4 1 1 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 EKE40709.1 - 8.4e-10 38.8 22.1 1.8e-05 25.0 0.1 5.4 5 1 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EKE40709.1 - 0.098 13.3 10.6 14 6.7 0.5 6.1 5 2 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.7 EKE40710.1 - 0.0054 17.1 7.9 0.053 14.0 0.4 4.6 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) HIT PF01230.23 EKE40711.1 - 7.7e-28 97.1 0.1 8.7e-28 96.9 0.1 1.0 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EKE40711.1 - 6.1e-25 87.9 0.0 7.1e-25 87.7 0.0 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EKE40711.1 - 0.0043 16.9 0.2 0.0046 16.8 0.2 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 GalP_UDP_tr_C PF02744.17 EKE40711.1 - 0.033 13.9 0.1 0.046 13.5 0.1 1.3 1 1 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain DEAD PF00270.29 EKE40712.1 - 4.7e-47 160.0 0.9 4.7e-47 160.0 0.9 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE40712.1 - 5.4e-29 100.8 1.8 1.4e-28 99.4 0.4 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE40712.1 - 4.8e-07 29.9 0.1 1.5e-06 28.3 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EKE40712.1 - 0.0005 20.4 0.1 0.001 19.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EKE40712.1 - 0.0033 17.2 0.1 0.0068 16.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKE40712.1 - 0.006 16.9 0.2 0.033 14.5 0.2 2.2 1 1 0 1 1 1 1 AAA domain CMS1 PF14617.6 EKE40712.1 - 0.01 15.2 0.0 0.01 15.2 0.0 1.6 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 EKE40712.1 - 0.038 13.8 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 Helicase WD40 PF00400.32 EKE40713.1 - 1.5e-06 28.8 0.0 2.3e-06 28.2 0.0 1.3 1 1 0 1 1 1 1 WD domain, G-beta repeat MFS_1 PF07690.16 EKE40714.1 - 2.1e-19 69.6 39.2 4.2e-14 52.2 9.7 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EKE40714.1 - 4.8e-14 52.5 10.8 4.8e-14 52.5 10.8 2.6 3 0 0 3 3 3 1 Nodulin-like TLD PF07534.16 EKE40715.1 - 0.0042 17.3 2.0 0.012 15.8 2.0 1.7 1 0 0 1 1 1 1 TLD Mem_trans PF03547.18 EKE40715.1 - 0.0042 15.5 1.9 0.0061 15.0 1.9 1.1 1 0 0 1 1 1 1 Membrane transport protein DUF1759 PF03564.15 EKE40715.1 - 0.0054 16.7 1.7 0.015 15.2 1.7 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) HMMR_N PF15905.5 EKE40715.1 - 0.0066 16.0 9.5 0.0066 16.0 9.5 2.0 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal ERM PF00769.19 EKE40715.1 - 0.0098 15.7 3.1 0.014 15.3 3.1 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family CENP-Q PF13094.6 EKE40715.1 - 0.038 14.2 3.5 0.061 13.5 3.5 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Flagellin_N PF00669.20 EKE40715.1 - 0.57 10.3 3.2 1.2 9.3 3.2 1.4 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region MCPsignal PF00015.21 EKE40715.1 - 4.3 7.1 7.4 0.74 9.6 3.5 1.7 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain zf-UBR PF02207.20 EKE40717.1 - 2.6e-18 65.9 14.7 2.6e-18 65.9 14.7 2.5 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) DUF4164 PF13747.6 EKE40720.1 - 0.035 14.4 2.9 0.038 14.3 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) bacHORMA_2 PF18173.1 EKE40720.1 - 0.084 12.7 0.2 5.2 6.9 0.1 2.3 2 0 0 2 2 2 0 Bacterial HORMA domain 2 LPP PF04728.13 EKE40720.1 - 0.16 12.4 4.8 5.7 7.4 1.2 3.2 2 1 1 3 3 3 0 Lipoprotein leucine-zipper AI-2E_transport PF01594.16 EKE40720.1 - 4.6 6.3 6.4 2.4 7.2 1.0 2.2 2 0 0 2 2 2 0 AI-2E family transporter JAB PF01398.21 EKE40721.1 - 1.3e-25 89.6 0.0 2.3e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EKE40721.1 - 2.6e-05 24.0 0.0 4.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EKE40721.1 - 0.00023 21.3 0.0 0.0005 20.2 0.0 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0172) DUF5344 PF17279.2 EKE40722.1 - 0.0077 16.8 6.2 3.7 8.2 0.7 4.7 4 0 0 4 4 4 2 Family of unknown function (DUF5344) vATP-synt_E PF01991.18 EKE40723.1 - 1.1e-39 135.9 16.0 1.5e-39 135.5 16.0 1.2 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF1749 PF08538.10 EKE40723.1 - 0.12 11.5 2.2 1.2 8.1 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) Phage_CI_repr PF07022.13 EKE40724.1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain Mu-like_Com PF10122.9 EKE40724.1 - 0.13 11.8 0.2 0.33 10.4 0.2 1.7 1 0 0 1 1 1 0 Mu-like prophage protein Com Ank_2 PF12796.7 EKE40725.1 - 5e-21 75.1 1.0 5.1e-14 52.6 0.1 2.6 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Bromodomain PF00439.25 EKE40725.1 - 6.8e-18 64.5 1.0 6.8e-18 64.5 1.0 2.5 3 0 0 3 3 3 1 Bromodomain Ank_3 PF13606.6 EKE40725.1 - 4.8e-17 60.3 0.8 0.0021 18.4 0.0 5.8 4 1 1 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EKE40725.1 - 2.1e-14 53.4 0.2 3.8e-08 33.4 0.2 4.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EKE40725.1 - 2.4e-11 43.9 1.1 0.00013 22.4 0.1 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EKE40725.1 - 2e-09 37.5 0.2 0.072 13.6 0.0 4.9 4 0 0 4 4 4 2 Ankyrin repeat BET PF17035.5 EKE40725.1 - 0.0024 18.0 0.1 0.0024 18.0 0.1 3.1 2 1 1 3 3 3 1 Bromodomain extra-terminal - transcription regulation DUF3447 PF11929.8 EKE40725.1 - 0.068 13.1 11.7 1.4 8.9 0.1 4.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3447) SH3_15 PF18346.1 EKE40725.1 - 0.13 12.6 0.1 3.4 8.0 0.0 2.5 2 0 0 2 2 2 0 Mind bomb SH3 repeat domain SIR2 PF02146.17 EKE40726.1 - 4.1e-51 173.4 0.0 6.3e-51 172.8 0.0 1.3 1 0 0 1 1 1 1 Sir2 family zf-RING_13 PF17977.1 EKE40726.1 - 0.12 12.5 0.0 0.12 12.5 0.0 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Synuclein PF01387.17 EKE40727.1 - 0.018 15.2 0.1 4.1 7.6 0.0 2.3 2 0 0 2 2 2 0 Synuclein RNA_pol_Rpb1_5 PF04998.17 EKE40727.1 - 0.13 11.7 3.8 0.22 10.9 3.8 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 DUF1230 PF06799.11 EKE40727.1 - 0.98 9.5 4.8 0.19 11.9 0.9 1.9 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 VHP PF02209.19 EKE40728.1 - 1.1e-11 44.6 2.9 1.1e-11 44.6 2.9 2.3 2 0 0 2 2 2 1 Villin headpiece domain Gelsolin PF00626.22 EKE40728.1 - 4.7e-05 23.2 0.0 4.7e-05 23.2 0.0 3.0 4 0 0 4 4 4 1 Gelsolin repeat MFS_1 PF07690.16 EKE40730.1 - 3e-33 115.2 12.4 1.6e-26 93.1 11.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EKE40730.1 - 0.00021 19.8 0.0 0.00021 19.8 0.0 1.4 2 0 0 2 2 2 1 Transmembrane secretion effector Bromodomain PF00439.25 EKE40731.1 - 5.1e-22 77.7 4.0 1.1e-21 76.6 0.2 2.9 2 1 1 3 3 3 1 Bromodomain BTB PF00651.31 EKE40731.1 - 6.1e-05 23.2 0.0 0.00021 21.5 0.0 2.0 1 0 0 1 1 1 1 BTB/POZ domain DnaJ_C PF01556.18 EKE40732.1 - 2.1e-09 37.7 3.8 2e-07 31.2 3.5 2.8 2 1 0 2 2 2 2 DnaJ C terminal domain ABM PF03992.16 EKE40733.1 - 5.2e-16 58.5 0.0 7e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase PAP_RNA-bind PF04926.15 EKE40733.1 - 0.018 14.7 0.2 0.018 14.7 0.2 1.1 1 0 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain DUF4188 PF13826.6 EKE40733.1 - 0.019 15.3 0.1 0.021 15.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4188) SHS2_Rpb7-N PF03876.17 EKE40735.1 - 1.7e-05 25.1 0.1 4.2e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.12 EKE40735.1 - 9.7e-05 22.6 0.0 0.00015 22.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 S1 PF00575.23 EKE40735.1 - 0.00026 21.3 2.2 0.00038 20.7 1.5 1.6 1 1 0 1 1 1 1 S1 RNA binding domain PX PF00787.24 EKE40736.1 - 4.9e-05 23.3 0.2 0.00028 20.8 0.2 2.4 1 0 0 1 1 1 1 PX domain CSTF_C PF14304.6 EKE40736.1 - 0.099 12.2 1.3 0.22 11.1 1.3 1.6 1 0 0 1 1 1 0 Transcription termination and cleavage factor C-terminal EamA PF00892.20 EKE40737.1 - 5.9e-06 26.5 12.8 5.9e-06 26.5 12.8 3.5 2 2 1 3 3 3 1 EamA-like transporter family PUNUT PF16913.5 EKE40737.1 - 1.1e-05 24.9 16.3 2.7e-05 23.6 16.1 2.1 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport TPT PF03151.16 EKE40737.1 - 0.0024 17.3 6.3 0.0024 17.3 6.3 2.4 2 0 0 2 2 2 1 Triose-phosphate Transporter family EAP30 PF04157.16 EKE40738.1 - 6.9e-35 120.4 0.1 8.3e-35 120.2 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family YkyA PF10368.9 EKE40739.1 - 0.014 15.1 3.1 0.023 14.4 3.1 1.4 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein HTH_45 PF14947.6 EKE40739.1 - 0.031 14.2 0.9 0.12 12.3 0.3 2.3 1 1 2 3 3 3 0 Winged helix-turn-helix Arm PF00514.23 EKE40740.1 - 7.9e-05 22.6 1.6 3.4 7.8 0.0 5.6 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat UCH PF00443.29 EKE40741.1 - 7.5e-41 140.3 5.5 8.9e-41 140.1 5.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE40741.1 - 9.6e-06 25.4 8.8 0.0035 17.0 8.8 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RRP7 PF12923.7 EKE40741.1 - 0.04 14.1 0.3 0.071 13.2 0.3 1.4 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Sec63 PF02889.16 EKE40742.1 - 4.7e-110 366.8 5.0 3.2e-55 187.1 1.7 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EKE40742.1 - 1.4e-52 178.0 3.3 7.4e-26 91.0 0.4 3.1 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 EKE40742.1 - 4.1e-28 98.5 0.6 1.4e-13 51.2 0.1 3.1 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EKE40742.1 - 1.3e-18 67.4 0.1 6.5e-08 32.9 0.1 3.8 2 2 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EKE40742.1 - 3.6e-09 37.0 0.5 0.00063 20.0 0.2 3.1 3 1 0 3 3 2 2 AAA domain AAA_30 PF13604.6 EKE40742.1 - 2.8e-07 30.5 0.1 0.0066 16.2 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 EKE40742.1 - 1.2e-06 28.9 2.6 0.00025 21.4 0.6 2.7 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 EKE40742.1 - 4.2e-05 23.1 0.0 0.22 11.0 0.0 2.7 2 0 0 2 2 2 2 PhoH-like protein T2SSE PF00437.20 EKE40742.1 - 0.00017 20.8 0.0 0.17 10.9 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein SNF2_N PF00176.23 EKE40742.1 - 0.00027 19.8 3.1 0.0059 15.4 0.6 2.3 2 0 0 2 2 2 1 SNF2 family N-terminal domain AAA PF00004.29 EKE40742.1 - 0.00085 19.8 3.8 0.55 10.7 0.5 3.7 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EKE40742.1 - 0.0051 16.3 1.3 1.8 8.0 0.1 3.2 3 0 0 3 3 3 1 P-loop containing dynein motor region DUF2075 PF09848.9 EKE40742.1 - 0.02 14.1 0.0 2.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 EKE40742.1 - 0.033 13.7 0.6 0.65 9.5 0.0 2.6 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain Terminase_6 PF03237.15 EKE40742.1 - 0.13 11.9 0.0 23 4.5 0.0 3.0 3 0 0 3 3 3 0 Terminase-like family DUF2632 PF10943.8 EKE40742.1 - 0.15 11.7 0.1 0.31 10.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2632) AAA_11 PF13086.6 EKE40742.1 - 0.19 11.5 0.7 1.9 8.2 0.0 2.9 2 2 2 4 4 4 0 AAA domain AAA_23 PF13476.6 EKE40742.1 - 6.4 7.2 5.6 1.8 9.0 0.1 3.0 4 0 0 4 4 2 0 AAA domain PTEN_C2 PF10409.9 EKE40743.1 - 3.7e-08 33.2 0.0 6.6e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Y_phosphatase PF00102.27 EKE40743.1 - 4.2e-07 29.8 0.0 8.5e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EKE40743.1 - 2.8e-05 23.9 0.0 5.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 EKE40743.1 - 0.0026 17.4 0.0 0.0049 16.5 0.0 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 EKE40743.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EKE40743.1 - 0.017 15.2 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate La PF05383.17 EKE40746.1 - 4.5e-18 65.0 0.9 1.1e-17 63.8 0.1 2.2 2 0 0 2 2 2 1 La domain RRM_1 PF00076.22 EKE40746.1 - 0.00048 19.9 0.5 0.0011 18.8 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Exog_C PF18026.1 EKE40746.1 - 0.8 9.8 6.0 0.31 11.1 0.4 2.9 3 0 0 3 3 3 0 Endo/exonuclease (EXOG) C-terminal domain Dopey_N PF04118.14 EKE40747.1 - 5.9e-24 84.7 14.7 1.1e-23 83.8 11.7 3.0 2 1 0 2 2 2 1 Dopey, N-terminal W2 PF02020.18 EKE40748.1 - 3.1e-12 46.5 1.1 3.1e-12 46.5 1.1 2.1 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.23 EKE40748.1 - 3.4e-07 30.1 0.6 1.3e-06 28.2 0.5 1.9 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 EKE40748.1 - 1.3e-06 27.9 12.1 0.0018 17.9 3.5 2.7 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EKE40748.1 - 0.033 13.1 4.2 0.029 13.3 1.9 2.0 2 0 0 2 2 2 0 L-fucokinase DUF4441 PF14536.6 EKE40748.1 - 0.14 12.4 5.7 0.063 13.5 0.8 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4441) DUF1394 PF07159.12 EKE40750.1 - 3.5e-93 312.2 1.8 4.1e-93 312.0 1.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) FEZ PF07763.13 EKE40750.1 - 0.021 14.6 0.3 0.034 13.9 0.3 1.3 1 0 0 1 1 1 0 FEZ-like protein DUF2779 PF11074.8 EKE40750.1 - 0.037 14.5 0.5 0.075 13.5 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function(DUF2779) DUF2552 PF10827.8 EKE40750.1 - 0.11 12.7 0.1 14 6.0 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2552) CS PF04969.16 EKE40751.1 - 1.6e-14 54.7 4.0 2.8e-14 53.9 4.0 1.4 1 0 0 1 1 1 1 CS domain Big_1 PF02369.16 EKE40751.1 - 0.095 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) MgsA_C PF12002.8 EKE40752.1 - 2.5e-36 125.1 0.0 5e-36 124.1 0.0 1.5 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EKE40752.1 - 1.1e-19 70.5 1.4 1.8e-18 66.6 0.2 2.8 2 1 0 2 2 1 1 AAA C-terminal domain AAA PF00004.29 EKE40752.1 - 2.4e-18 66.8 3.2 1.2e-15 58.1 0.3 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EKE40752.1 - 3e-13 49.8 0.0 5.4e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EKE40752.1 - 2e-06 27.8 0.1 4.4e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EKE40752.1 - 5.2e-06 26.3 0.1 0.00028 20.6 0.1 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EKE40752.1 - 1.4e-05 25.3 0.1 5.1e-05 23.4 0.0 2.0 2 0 0 2 2 1 1 Sigma-54 interaction domain AAA_22 PF13401.6 EKE40752.1 - 1.9e-05 25.0 3.2 0.0007 19.9 0.1 3.2 1 1 1 3 3 3 1 AAA domain AAA_14 PF13173.6 EKE40752.1 - 2.1e-05 24.6 0.2 2.1e-05 24.6 0.2 3.2 1 1 2 3 3 3 1 AAA domain AAA_17 PF13207.6 EKE40752.1 - 2.6e-05 24.7 2.7 0.11 12.9 0.2 3.1 1 1 2 3 3 3 2 AAA domain Zeta_toxin PF06414.12 EKE40752.1 - 4.9e-05 22.7 0.0 9.4e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_19 PF13245.6 EKE40752.1 - 0.00015 22.1 3.5 0.14 12.4 0.1 3.1 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 EKE40752.1 - 0.00024 20.9 0.1 0.015 15.0 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EKE40752.1 - 0.00025 21.6 0.8 0.00071 20.1 0.0 2.1 2 2 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EKE40752.1 - 0.00027 20.4 0.6 0.099 12.0 0.0 2.7 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EKE40752.1 - 0.00056 19.5 1.6 0.00066 19.2 0.4 1.7 2 0 0 2 2 1 1 P-loop containing dynein motor region ADK PF00406.22 EKE40752.1 - 0.0011 19.1 0.4 0.41 10.7 0.0 2.6 1 1 1 2 2 2 1 Adenylate kinase AAA_16 PF13191.6 EKE40752.1 - 0.0014 19.0 0.8 0.15 12.4 0.0 2.9 3 1 1 4 4 2 1 AAA ATPase domain ABC_tran PF00005.27 EKE40752.1 - 0.0018 18.8 0.6 0.006 17.1 0.1 2.1 2 0 0 2 2 2 1 ABC transporter NB-ARC PF00931.22 EKE40752.1 - 0.0022 17.2 0.5 0.032 13.4 0.5 2.3 1 1 1 2 2 2 1 NB-ARC domain AAA_24 PF13479.6 EKE40752.1 - 0.0022 17.7 0.4 0.0066 16.2 0.1 1.9 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EKE40752.1 - 0.0031 17.3 1.8 0.0057 16.4 0.1 2.3 3 1 0 3 3 2 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 EKE40752.1 - 0.0037 17.0 0.0 0.031 14.0 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein ATP-synt_ab PF00006.25 EKE40752.1 - 0.0071 16.0 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_33 PF13671.6 EKE40752.1 - 0.014 15.6 0.0 0.032 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain CdiA_C PF18451.1 EKE40752.1 - 0.037 14.2 13.6 0.069 13.4 0.2 3.9 2 1 1 3 3 3 0 Contact-dependent growth inhibition CdiA C-terminal domain DUF5461 PF17545.2 EKE40752.1 - 0.056 13.7 0.6 2.6 8.4 0.3 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5461) AAA_28 PF13521.6 EKE40752.1 - 0.057 13.7 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF1697 PF08002.11 EKE40752.1 - 0.11 13.0 1.0 1.4 9.3 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1697) CPT PF07931.12 EKE40752.1 - 0.16 11.8 0.0 0.37 10.6 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Zot PF05707.12 EKE40752.1 - 0.17 11.5 3.0 6.9 6.3 0.1 3.0 2 1 1 3 3 3 0 Zonular occludens toxin (Zot) ResIII PF04851.15 EKE40752.1 - 1.2 9.1 11.8 0.032 14.3 2.4 2.7 2 2 1 3 3 3 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 EKE40752.1 - 2.7 7.9 6.4 1.2 9.1 0.2 3.0 2 1 2 4 4 4 0 NTPase WD40_like PF17005.5 EKE40753.1 - 0.00012 21.5 0.1 0.54 9.5 0.0 3.0 3 1 0 3 3 3 2 WD40-like domain WD40 PF00400.32 EKE40753.1 - 0.013 16.4 14.3 0.25 12.3 0.1 5.3 7 0 0 7 7 7 0 WD domain, G-beta repeat DUF3591 PF12157.8 EKE40754.1 - 8.5e-88 294.9 1.5 8.5e-88 294.9 1.5 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF3591) Bromodomain PF00439.25 EKE40754.1 - 7.2e-16 58.0 1.4 2.2e-15 56.5 0.4 2.4 2 0 0 2 2 2 1 Bromodomain TFIIF_beta PF02270.15 EKE40754.1 - 0.033 14.3 0.0 0.21 11.7 0.0 2.5 2 0 0 2 2 2 0 TFIIF, beta subunit HTH domain DUF3365 PF11845.8 EKE40755.1 - 0.11 12.9 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) Pkr1 PF08636.10 EKE40756.1 - 2.9e-19 69.0 3.0 3.6e-19 68.7 3.0 1.1 1 0 0 1 1 1 1 ER protein Pkr1 DUF4199 PF13858.6 EKE40756.1 - 0.0032 17.9 0.2 0.024 15.0 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF4199) DUF4234 PF14018.6 EKE40756.1 - 0.12 12.5 1.4 0.4 10.8 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4234) B12D PF06522.11 EKE40756.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit DUF1414 PF07208.11 EKE40756.1 - 0.17 11.9 0.2 0.35 10.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1414) DUF167 PF02594.16 EKE40757.1 - 2.5e-25 88.4 0.1 4e-25 87.7 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 Cpn10 PF00166.21 EKE40758.1 - 5e-19 68.1 0.1 5.6e-19 68.0 0.1 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit DUF5305 PF17231.2 EKE40761.1 - 0.16 11.3 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) PAP2 PF01569.21 EKE40763.1 - 2.8e-22 78.9 2.8 2.8e-22 78.9 2.8 1.9 1 1 1 2 2 2 1 PAP2 superfamily 7TMR-DISM_7TM PF07695.11 EKE40763.1 - 0.014 15.3 15.6 0.017 15.0 5.7 2.3 2 0 0 2 2 2 0 7TM diverse intracellular signalling TPPK_C PF12555.8 EKE40763.1 - 0.094 12.8 0.3 6.2 6.9 0.1 2.6 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal MerC PF03203.14 EKE40763.1 - 1.3 9.5 6.6 0.44 11.0 0.5 2.5 3 0 0 3 3 3 0 MerC mercury resistance protein UPF0014 PF03649.13 EKE40763.1 - 4.7 6.5 10.7 0.084 12.2 0.4 2.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0014) RNB PF00773.19 EKE40764.1 - 1.1e-11 44.7 12.8 1.7e-09 37.5 1.7 3.9 2 1 0 3 3 3 2 RNB domain TACC_C PF05010.14 EKE40765.1 - 0.2 11.5 50.0 0.027 14.3 23.9 2.3 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal KRAB PF01352.27 EKE40765.1 - 0.23 11.2 8.1 0.81 9.4 0.0 3.3 4 0 0 4 4 4 0 KRAB box GAS PF13851.6 EKE40765.1 - 0.24 10.7 55.8 0.25 10.7 5.3 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding ERM PF00769.19 EKE40765.1 - 0.24 11.2 48.5 3.2 7.5 37.6 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DivIC PF04977.15 EKE40765.1 - 0.37 10.6 55.4 0.26 11.1 12.8 5.2 1 1 4 5 5 5 0 Septum formation initiator Cnn_1N PF07989.11 EKE40765.1 - 0.49 10.6 51.3 0.47 10.7 1.8 4.8 2 2 1 3 3 3 0 Centrosomin N-terminal motif 1 DUF4461 PF14688.6 EKE40765.1 - 0.56 10.0 14.6 0.71 9.6 1.7 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4461) TPR_MLP1_2 PF07926.12 EKE40765.1 - 0.77 9.8 45.4 0.099 12.7 25.0 3.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF484 PF04340.12 EKE40765.1 - 1.1 8.9 8.4 1.4 8.5 5.6 2.2 1 1 1 2 2 2 0 Protein of unknown function, DUF484 Fez1 PF06818.15 EKE40765.1 - 1.7 9.1 40.8 0.099 13.1 31.2 2.2 1 1 1 2 2 2 0 Fez1 ATG16 PF08614.11 EKE40765.1 - 1.9 8.7 41.9 0.97 9.6 13.9 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TMPIT PF07851.13 EKE40765.1 - 2.3 7.4 43.9 0.55 9.4 20.6 2.1 1 1 0 2 2 2 0 TMPIT-like protein CPG4 PF15481.6 EKE40765.1 - 8.2 7.1 8.2 0.69 10.6 1.9 2.4 3 0 0 3 3 3 0 Chondroitin proteoglycan 4 Pkinase_Tyr PF07714.17 EKE40766.1 - 6e-42 143.7 0.2 8.2e-42 143.3 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40766.1 - 1.8e-39 135.7 0.5 2.5e-39 135.2 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EKE40766.1 - 0.00011 21.7 0.0 0.00018 20.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EKE40766.1 - 0.035 13.7 0.1 0.5 9.9 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 AA_permease_2 PF13520.6 EKE40767.1 - 1.3e-25 90.2 55.9 4e-25 88.5 50.3 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 EKE40767.1 - 4.4e-10 38.8 48.5 9.1e-10 37.7 48.5 1.5 1 1 0 1 1 1 1 Amino acid permease Pilin_N PF07790.11 EKE40767.1 - 1.1 10.3 0.1 1.1 10.3 0.1 2.8 3 0 0 3 3 3 0 Archaeal Type IV pilin, N-terminal Neur_chan_memb PF02932.16 EKE40768.1 - 9.4e-06 25.8 7.3 1.6e-05 25.1 7.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Shisa PF13908.6 EKE40768.1 - 0.009 16.3 0.1 0.029 14.6 0.1 1.8 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 EKE40768.1 - 0.012 16.5 0.5 0.012 16.5 0.5 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Bac_transf PF02397.16 EKE40768.1 - 0.097 12.3 0.3 0.2 11.2 0.3 1.5 1 0 0 1 1 1 0 Bacterial sugar transferase HemY_N PF07219.13 EKE40768.1 - 0.19 11.9 7.9 0.22 11.7 0.1 2.3 2 0 0 2 2 2 0 HemY protein N-terminus Syndecan PF01034.20 EKE40768.1 - 0.61 10.0 2.8 1.8 8.5 2.8 1.7 1 0 0 1 1 1 0 Syndecan domain SieB PF14163.6 EKE40768.1 - 0.7 9.4 7.0 7.2 6.1 7.0 2.8 1 1 0 1 1 1 0 Super-infection exclusion protein B DUF4389 PF14333.6 EKE40768.1 - 0.88 9.5 3.1 1.7 8.6 3.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) Arm PF00514.23 EKE40769.1 - 0.0044 17.0 1.0 14 5.9 0.0 4.5 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Arm_vescicular PF18770.1 EKE40769.1 - 3.1 7.8 9.2 0.93 9.5 2.9 3.0 3 0 0 3 3 3 0 Armadillo tether-repeat of vescicular transport factor Period_C PF12114.8 EKE40770.1 - 0.035 13.7 1.5 0.061 12.9 1.5 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region GSIII_N PF12437.8 EKE40772.1 - 4e-61 205.4 0.0 7.4e-61 204.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase type III N terminal Gln-synt_C-ter PF18318.1 EKE40772.1 - 2.3e-28 98.4 1.9 4.6e-28 97.4 1.9 1.5 1 0 0 1 1 1 1 Glutamine synthetase C-terminal domain Gln-synt_C PF00120.24 EKE40772.1 - 1.2e-23 83.7 0.1 1.3e-22 80.3 0.0 2.3 3 0 0 3 3 3 1 Glutamine synthetase, catalytic domain DUF1048 PF06304.11 EKE40772.1 - 0.05 14.1 0.0 5.1 7.6 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1048) Pkinase PF00069.25 EKE40773.1 - 1.3e-71 241.1 1.2 1.8e-51 175.0 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40773.1 - 4.9e-43 147.3 0.0 7.4e-32 110.6 0.0 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EKE40773.1 - 0.00028 19.9 2.3 0.00045 19.3 2.3 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EKE40773.1 - 0.0031 16.9 0.1 1.7 7.9 0.0 3.0 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 EKE40773.1 - 0.0077 15.1 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Filamin PF00630.19 EKE40774.1 - 1.5e-90 298.8 38.7 7.5e-21 74.9 14.5 5.5 5 1 0 5 5 5 5 Filamin/ABP280 repeat CH PF00307.31 EKE40774.1 - 5.8e-40 135.9 1.3 2e-21 76.2 1.3 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain Invasin_D3 PF09134.10 EKE40774.1 - 5.2e-10 39.5 1.6 0.063 13.6 0.0 5.6 5 1 1 6 6 5 2 Invasin, domain 3 CAMSAP_CH PF11971.8 EKE40774.1 - 7.7e-07 28.9 0.0 0.035 14.0 0.0 2.3 2 0 0 2 2 2 2 CAMSAP CH domain Neurexophilin PF06312.12 EKE40774.1 - 9.7e-06 25.2 0.0 0.019 14.5 0.2 2.6 2 0 0 2 2 2 2 Neurexophilin YtkA PF13115.6 EKE40774.1 - 2.1e-05 25.0 21.4 0.046 14.3 0.5 5.5 5 0 0 5 5 5 2 YtkA-like CH_2 PF06294.11 EKE40774.1 - 7.5e-05 22.8 0.7 0.27 11.4 0.2 2.3 2 0 0 2 2 2 2 CH-like domain in sperm protein Y_Y_Y PF07495.13 EKE40774.1 - 0.005 16.8 0.9 1.8 8.6 0.2 4.1 3 1 1 4 4 4 1 Y_Y_Y domain DUF5060 PF16586.5 EKE40774.1 - 0.0076 16.6 0.1 16 5.9 0.0 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5060) Big_1 PF02369.16 EKE40774.1 - 0.015 15.3 0.6 14 5.7 0.0 4.1 5 0 0 5 5 3 0 Bacterial Ig-like domain (group 1) EMP24_GP25L PF01105.24 EKE40774.1 - 0.064 13.2 1.2 27 4.6 0.0 3.4 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD FixH PF05751.11 EKE40774.1 - 0.091 12.8 0.1 75 3.3 0.0 3.6 3 1 0 3 3 3 0 FixH SDA1 PF05285.12 EKE40774.1 - 0.16 11.4 32.0 0.29 10.5 32.0 1.3 1 0 0 1 1 1 0 SDA1 Flagellin_D3 PF08884.11 EKE40774.1 - 0.31 11.4 8.3 2.8 8.4 0.1 3.7 3 0 0 3 3 3 0 Flagellin D3 domain Presenilin PF01080.17 EKE40774.1 - 0.42 9.3 11.7 0.64 8.7 11.7 1.2 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 EKE40774.1 - 0.56 10.3 4.9 1.5 8.9 4.9 1.7 1 0 0 1 1 1 0 DDHD domain Nop14 PF04147.12 EKE40774.1 - 0.59 8.3 27.2 0.88 7.7 27.2 1.2 1 0 0 1 1 1 0 Nop14-like family Raftlin PF15250.6 EKE40774.1 - 0.66 8.7 12.4 1.1 8.0 12.4 1.2 1 0 0 1 1 1 0 Raftlin Nop53 PF07767.11 EKE40774.1 - 1.1 8.6 28.6 2.1 7.6 28.6 1.5 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Neur_chan_memb PF02932.16 EKE40774.1 - 1.5 8.9 3.4 2.9 7.9 3.4 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SURF2 PF05477.11 EKE40774.1 - 2.9 7.5 19.3 8.5 6.0 19.3 1.8 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) CDC45 PF02724.14 EKE40774.1 - 3.4 5.8 18.6 5.1 5.3 18.6 1.2 1 0 0 1 1 1 0 CDC45-like protein PRP3 PF08572.10 EKE40775.1 - 1e-29 103.9 18.9 1e-29 103.9 18.9 2.1 1 1 1 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EKE40775.1 - 8.5e-08 32.4 3.3 2.5e-05 24.4 0.4 3.8 2 1 2 4 4 4 2 Protein of unknown function (DUF1115) Spt5-NGN PF03439.13 EKE40775.1 - 0.016 15.1 0.8 1.6 8.7 0.1 3.0 2 0 0 2 2 2 0 Early transcription elongation factor of RNA pol II, NGN section DDR_swiveling PF18427.1 EKE40776.1 - 1.5 8.8 8.5 0.14 12.2 3.2 2.0 2 0 0 2 2 2 0 DD-reactivating factor swiveling domain Pox_A_type_inc PF04508.12 EKE40776.1 - 4.6 7.2 20.0 1.4 8.9 0.9 6.3 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat DDOST_48kD PF03345.14 EKE40777.1 - 6.6e-25 87.8 0.4 7e-17 61.4 0.1 2.4 1 1 1 2 2 2 2 Oligosaccharyltransferase 48 kDa subunit beta ABC_transp_aux PF09822.9 EKE40777.1 - 0.011 15.2 0.1 0.029 13.9 0.0 1.7 1 1 1 2 2 2 0 ABC-type uncharacterized transport system IF4E PF01652.18 EKE40779.1 - 2e-30 105.7 3.3 2.4e-30 105.5 3.3 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Peptidase_C1 PF00112.23 EKE40780.1 - 0.0056 16.8 1.4 1.2 9.1 0.4 2.7 1 1 0 2 2 2 2 Papain family cysteine protease Ras PF00071.22 EKE40781.1 - 1.8e-09 37.4 0.1 0.00075 19.1 0.0 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EKE40781.1 - 0.061 13.5 0.0 0.74 10.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RasGEF PF00617.19 EKE40782.1 - 9.9e-16 58.4 3.1 2.8e-15 57.0 3.1 1.8 1 0 0 1 1 1 1 RasGEF domain CMV_1a PF12467.8 EKE40782.1 - 0.0053 17.1 0.9 0.42 11.0 0.1 2.6 2 0 0 2 2 2 1 Cucumber mosaic virus 1a protein family Poxvirus_B22R PF04395.12 EKE40782.1 - 0.33 10.4 4.3 0.29 10.7 1.5 2.2 2 0 0 2 2 2 0 Poxvirus B22R protein zf-CRD PF17979.1 EKE40782.1 - 7.8 6.6 8.2 6.7 6.8 1.3 2.8 3 1 0 3 3 3 0 Cysteine rich domain with multizinc binding regions RRM_1 PF00076.22 EKE40784.1 - 6.6e-10 38.7 0.0 8e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE40784.1 - 0.013 15.5 0.1 0.022 14.8 0.1 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.22 EKE40785.1 - 5.1e-16 58.3 0.0 1e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Menin PF05053.13 EKE40785.1 - 0.78 8.0 9.3 0.93 7.8 9.3 1.0 1 0 0 1 1 1 0 Menin O-antigen_lig PF13425.6 EKE40785.1 - 2.7 6.7 5.4 3.2 6.5 5.4 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein GBP_C PF02841.14 EKE40785.1 - 2.8 7.3 23.1 3.5 7.0 23.1 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Neur_chan_memb PF02932.16 EKE40785.1 - 3.3 7.7 6.8 3.9 7.5 6.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 EKE40785.1 - 4.6 6.0 11.0 5.3 5.8 11.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Paramyxo_ncap PF00973.19 EKE40785.1 - 6 5.7 12.9 7.8 5.3 12.9 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Peptidase_U32 PF01136.19 EKE40786.1 - 0.069 12.3 0.0 0.091 11.9 0.0 1.1 1 0 0 1 1 1 0 Peptidase family U32 RasGEF PF00617.19 EKE40787.1 - 1e-35 123.6 0.0 2.1e-35 122.5 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE40787.1 - 0.0046 17.2 0.0 0.017 15.4 0.0 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif Pkinase_Tyr PF07714.17 EKE40788.1 - 1e-06 28.3 0.0 1.3e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase MCPsignal PF00015.21 EKE40789.1 - 0.044 13.6 1.2 0.87 9.4 0.0 2.5 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain EOS1 PF12326.8 EKE40789.1 - 1.9 8.4 4.8 16 5.4 4.8 2.3 1 1 0 1 1 1 0 N-glycosylation protein MT0933_antitox PF14013.6 EKE40789.1 - 2.4 8.6 29.3 0.38 11.1 0.9 5.6 3 2 0 4 4 4 0 MT0933-like antitoxin protein Pkinase PF00069.25 EKE40790.1 - 2.5e-47 161.5 0.1 4.9e-47 160.5 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40790.1 - 2.5e-33 115.4 0.0 4.7e-33 114.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase DUF1163 PF06651.11 EKE40790.1 - 0.018 15.1 0.1 0.04 14.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1163) Pkinase PF00069.25 EKE40791.1 - 1.8e-72 243.9 0.0 2.5e-72 243.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40791.1 - 1.9e-37 129.0 0.0 2.6e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE40791.1 - 4.7e-20 72.0 0.4 1.1e-19 70.9 0.4 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EKE40791.1 - 5e-07 29.3 0.0 5.5e-05 22.6 0.0 2.3 1 1 0 2 2 2 1 Kinase-like PH_3 PF14593.6 EKE40791.1 - 6.9e-07 29.3 0.1 1.7e-06 28.1 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EKE40791.1 - 1.2e-06 28.9 1.4 1.9e-05 25.0 1.4 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 EKE40791.1 - 7.4e-05 23.0 0.1 0.00017 21.8 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain APH PF01636.23 EKE40791.1 - 0.00053 20.0 0.0 0.00087 19.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EKE40791.1 - 0.00087 19.0 0.4 0.75 9.4 0.0 2.8 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EKE40791.1 - 0.0032 16.3 0.0 0.0087 14.9 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EKE40791.1 - 0.0048 16.3 0.0 0.036 13.4 0.0 2.3 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PH_2 PF08458.10 EKE40791.1 - 0.017 15.4 0.0 0.032 14.6 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_4 PF15404.6 EKE40791.1 - 0.027 14.3 0.1 0.66 9.8 0.1 2.5 1 1 1 2 2 2 0 Pleckstrin homology domain PH_15 PF17339.2 EKE40791.1 - 0.091 12.7 0.5 0.32 10.9 0.0 2.0 2 0 0 2 2 2 0 PH domain Peptidase_C48 PF02902.19 EKE40792.1 - 2.4e-22 79.9 4.8 3.9e-22 79.2 4.8 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain YjeF_N PF03853.15 EKE40792.1 - 0.0035 17.3 0.0 0.0076 16.1 0.0 1.5 1 0 0 1 1 1 1 YjeF-related protein N-terminus ANAPC4_WD40 PF12894.7 EKE40793.1 - 0.011 16.0 1.9 0.92 9.9 0.0 4.2 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 EKE40793.1 - 0.032 13.9 0.0 0.1 12.3 0.0 1.9 1 0 0 1 1 1 0 LisH-like dimerisation domain LisH PF08513.11 EKE40793.1 - 0.032 14.2 0.0 0.1 12.6 0.0 2.0 1 0 0 1 1 1 0 LisH Gryzun-like PF12742.7 EKE40793.1 - 0.043 13.8 0.0 0.23 11.5 0.1 2.3 2 0 0 2 2 2 0 Gryzun, putative Golgi trafficking DUF1664 PF07889.12 EKE40793.1 - 1.5 8.9 6.5 1.7 8.7 3.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) RicinB_lectin_2 PF14200.6 EKE40794.1 - 2.2e-16 60.3 0.0 1.1e-14 54.9 0.0 2.4 1 1 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like MAD PF05557.13 EKE40794.1 - 0.013 13.9 0.2 0.017 13.5 0.2 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF2730 PF10805.8 EKE40794.1 - 0.024 14.7 0.5 0.056 13.5 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Rap_GAP PF02145.15 EKE40795.1 - 3.5e-54 183.2 0.2 3.5e-54 183.2 0.2 1.8 2 0 0 2 2 2 1 Rap/ran-GAP DUF4284 PF14112.6 EKE40796.1 - 0.93 10.4 5.6 4.2 8.3 0.1 3.2 3 0 0 3 3 3 0 Immunity protein 22 FMN_red PF03358.15 EKE40797.1 - 1.8e-36 125.3 0.0 2.3e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EKE40797.1 - 1.5e-11 44.4 0.0 2.2e-11 43.9 0.0 1.4 1 1 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 EKE40797.1 - 0.026 14.8 0.0 0.097 12.9 0.0 1.9 2 0 0 2 2 2 0 Flavodoxin domain Tyrosinase PF00264.20 EKE40798.1 - 0.2 11.9 5.3 0.24 11.7 5.3 1.1 1 0 0 1 1 1 0 Common central domain of tyrosinase SLY PF12485.8 EKE40798.1 - 1.2 9.9 9.6 1.7 9.3 9.6 1.4 1 0 0 1 1 1 0 Lymphocyte signaling adaptor protein Ndc1_Nup PF09531.10 EKE40798.1 - 1.2 7.7 8.3 1.4 7.5 8.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_C1 PF00112.23 EKE40799.1 - 2.7e-05 24.4 15.2 0.0001 22.5 10.8 2.9 2 1 0 2 2 2 1 Papain family cysteine protease MAP1B_neuraxin PF00414.17 EKE40799.1 - 0.03 13.9 0.2 0.086 12.4 0.2 1.8 1 0 0 1 1 1 0 Neuraxin and MAP1B repeat GCV_H PF01597.19 EKE40800.1 - 2e-06 27.7 0.1 5.3e-06 26.3 0.1 1.8 1 1 0 1 1 1 1 Glycine cleavage H-protein WWE PF02825.20 EKE40801.1 - 1.9e-09 38.0 4.8 2.9e-09 37.4 3.0 2.3 2 0 0 2 2 2 1 WWE domain BRCT_3 PF18428.1 EKE40801.1 - 0.00035 20.6 0.2 0.0011 19.0 0.2 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EKE40801.1 - 0.011 16.1 1.1 0.033 14.6 0.2 2.3 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain DRY_EERY PF09750.9 EKE40801.1 - 0.032 14.5 4.2 2 8.7 1.1 2.4 2 0 0 2 2 2 0 Alternative splicing regulator LMWSLP_N PF12211.8 EKE40801.1 - 0.1 12.2 0.2 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 Low molecular weight S layer protein N terminal TLP-20 PF06088.11 EKE40801.1 - 0.32 10.9 8.1 0.72 9.7 8.1 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RasGEF PF00617.19 EKE40802.1 - 2.1e-19 70.4 4.1 2.1e-19 70.4 4.1 2.5 3 0 0 3 3 3 1 RasGEF domain Imm30 PF15565.6 EKE40802.1 - 0.026 14.6 0.1 0.16 12.1 0.1 2.4 1 0 0 1 1 1 0 Immunity protein 30 DALR_1 PF05746.15 EKE40802.1 - 0.21 11.8 1.3 1.8 8.8 0.1 2.8 2 1 0 2 2 2 0 DALR anticodon binding domain Glyco_transf_8 PF01501.20 EKE40805.1 - 0.036 13.6 0.4 0.038 13.6 0.4 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 8 RhoGEF PF00621.20 EKE40806.1 - 1.5e-35 123.0 0.3 1.5e-35 123.0 0.3 1.8 2 0 0 2 2 2 1 RhoGEF domain Yop-YscD_ppl PF16693.5 EKE40806.1 - 0.051 13.0 0.0 0.077 12.4 0.0 1.3 1 0 0 1 1 1 0 Inner membrane component of T3SS, periplasmic domain IQ PF00612.27 EKE40806.1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif CorA PF01544.18 EKE40807.1 - 2.7e-45 154.9 6.5 3.5e-45 154.5 6.5 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein IL17R_D_N PF16742.5 EKE40807.1 - 0.082 13.0 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D DKNYY PF13644.6 EKE40807.1 - 8.5 7.1 7.7 3.9 8.3 1.1 2.2 1 1 1 2 2 2 0 DKNYY family MALT1_Ig PF18703.1 EKE40808.1 - 0.032 14.3 0.2 0.056 13.5 0.2 1.5 1 1 0 1 1 1 0 MALT1 Ig-like domain TMPIT PF07851.13 EKE40808.1 - 0.35 10.1 4.0 0.48 9.6 4.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein Peptidase_C50 PF03568.17 EKE40810.1 - 1e-66 225.7 0.0 7.7e-66 222.8 0.0 1.9 1 1 0 1 1 1 1 Peptidase family C50 CHAT PF12770.7 EKE40810.1 - 2.7e-06 27.0 0.0 0.00052 19.5 0.0 2.1 1 1 1 2 2 2 2 CHAT domain NAP PF00956.18 EKE40811.1 - 6.1e-13 48.6 11.1 3.9e-12 45.9 11.1 1.9 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) DUF5415 PF17436.2 EKE40811.1 - 0.0072 16.4 0.0 0.027 14.5 0.0 1.9 1 0 0 1 1 1 1 Family of unknown function (DUF5415) Phage_Mu_Gam PF07352.12 EKE40811.1 - 0.19 11.6 10.3 0.32 10.9 4.0 2.3 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein RE_HindIII PF09518.10 EKE40812.1 - 0.37 10.0 9.1 0.4 9.9 9.1 1.1 1 0 0 1 1 1 0 HindIII restriction endonuclease DUF3391 PF11871.8 EKE40812.1 - 0.57 10.7 8.3 1.5 9.4 8.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) DUF3450 PF11932.8 EKE40812.1 - 0.72 9.1 14.1 0.45 9.8 12.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Trimer_CC PF08954.11 EKE40812.1 - 0.91 9.1 8.3 0.21 11.2 4.9 1.8 2 0 0 2 2 2 0 Trimerisation motif TMPIT PF07851.13 EKE40812.1 - 1.4 8.1 11.2 1.5 8.0 11.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein GBP_C PF02841.14 EKE40812.1 - 1.6 8.1 16.7 1.8 7.9 16.7 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain FapA PF03961.13 EKE40812.1 - 1.8 7.1 15.3 2 7.0 15.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A FAM76 PF16046.5 EKE40812.1 - 2.1 7.6 11.8 2.2 7.6 11.8 1.0 1 0 0 1 1 1 0 FAM76 protein Atg14 PF10186.9 EKE40812.1 - 2.3 7.2 12.5 2.7 7.0 12.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PCRF PF03462.18 EKE40812.1 - 3.6 7.4 10.2 4.2 7.2 10.2 1.1 1 0 0 1 1 1 0 PCRF domain HIP1_clath_bdg PF16515.5 EKE40812.1 - 4.9 7.8 17.4 1.4 9.5 13.0 1.9 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Glyco_transf_41 PF13844.6 EKE40812.1 - 4.9 5.5 8.0 5 5.5 8.0 1.0 1 0 0 1 1 1 0 Glycosyl transferase family 41 YlbD_coat PF14071.6 EKE40812.1 - 5.9 7.2 14.2 12 6.1 14.2 1.7 1 1 0 1 1 1 0 Putative coat protein DUF2570 PF10828.8 EKE40812.1 - 6.5 6.6 15.0 0.6 10.0 9.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) HAD_2 PF13419.6 EKE40814.1 - 1.9e-26 93.2 0.8 2.3e-26 92.9 0.8 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EKE40814.1 - 6.2e-16 59.3 1.0 3.6e-15 56.8 1.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EKE40814.1 - 3.3e-08 34.2 0.0 4.2e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EKE40814.1 - 0.00011 22.2 0.0 0.036 14.2 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase NT5C PF06941.12 EKE40814.1 - 0.0014 18.6 0.1 0.0031 17.4 0.1 1.7 1 1 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Acid_PPase PF12689.7 EKE40814.1 - 0.012 15.4 0.5 0.084 12.7 0.5 2.1 1 1 0 1 1 1 0 Acid Phosphatase Fer4_12 PF13353.6 EKE40814.1 - 0.06 13.6 0.1 0.13 12.5 0.1 1.5 1 1 0 1 1 1 0 4Fe-4S single cluster domain GDPD PF03009.17 EKE40814.1 - 0.063 13.0 0.5 0.11 12.2 0.5 1.4 1 1 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Hydrolase_3 PF08282.12 EKE40814.1 - 0.43 10.3 7.9 4.7 6.9 0.1 3.1 1 1 2 3 3 3 0 haloacid dehalogenase-like hydrolase DUF3377 PF11857.8 EKE40815.1 - 0.014 15.3 0.2 0.033 14.1 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TMEM154 PF15102.6 EKE40815.1 - 0.057 13.3 0.2 0.13 12.2 0.2 1.5 1 0 0 1 1 1 0 TMEM154 protein family Cauli_VI PF01693.16 EKE40815.1 - 0.12 12.7 0.2 0.68 10.3 0.0 2.4 2 0 0 2 2 2 0 Caulimovirus viroplasmin Myticin-prepro PF10690.9 EKE40815.1 - 1.8 8.9 4.4 6.2 7.1 4.4 1.9 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel ANTH PF07651.16 EKE40816.1 - 2.2e-09 36.7 2.7 2.5e-09 36.5 2.7 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 EKE40816.1 - 0.0011 19.0 2.2 0.0022 18.0 2.2 1.4 1 0 0 1 1 1 1 ENTH domain DUF3868 PF12984.7 EKE40817.1 - 0.041 13.7 0.1 0.16 11.8 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3868) EF-hand_1 PF00036.32 EKE40818.1 - 1.2e-23 80.8 12.5 4.1e-07 29.1 0.2 4.8 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 EKE40818.1 - 7.4e-22 77.6 7.8 2e-13 50.5 0.1 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EKE40818.1 - 1.3e-18 66.6 7.7 4.2e-08 32.9 0.9 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EKE40818.1 - 1.5e-18 65.1 11.5 3.5e-05 23.4 0.1 4.7 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EKE40818.1 - 6.6e-18 63.3 5.6 8.6e-06 25.0 0.7 4.3 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.9 EKE40818.1 - 0.00012 22.4 0.2 0.049 13.9 0.0 2.6 2 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EKE40818.1 - 0.00013 21.8 1.1 0.059 13.3 0.1 2.4 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EKE40818.1 - 0.0035 17.6 0.1 0.024 15.0 0.0 2.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_14 PF17959.1 EKE40818.1 - 0.029 14.7 0.7 4.4 7.7 0.1 2.8 2 2 0 2 2 2 0 EF-hand domain START PF01852.19 EKE40819.1 - 1.6e-14 53.8 0.0 2e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 START domain DUF5410 PF17422.2 EKE40819.1 - 0.017 14.4 0.1 0.029 13.6 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5410) DUF3074 PF11274.8 EKE40819.1 - 0.037 14.0 0.1 0.07 13.1 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) C2 PF00168.30 EKE40822.1 - 2.3e-12 47.1 0.1 3.2e-12 46.6 0.0 1.3 2 0 0 2 2 2 1 C2 domain Metallophos PF00149.28 EKE40824.1 - 6.7e-12 46.3 0.7 1.2e-11 45.5 0.7 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WD40_like PF17005.5 EKE40825.1 - 6.2e-05 22.5 8.9 0.00012 21.5 0.6 3.3 3 0 0 3 3 3 2 WD40-like domain F-box PF00646.33 EKE40825.1 - 0.0096 15.8 1.6 0.0096 15.8 1.6 2.4 3 0 0 3 3 3 1 F-box domain WD40 PF00400.32 EKE40825.1 - 0.041 14.8 6.4 32 5.6 0.0 4.8 4 0 0 4 4 4 0 WD domain, G-beta repeat Pkinase PF00069.25 EKE40827.1 - 7.8e-50 169.7 0.0 1.2e-49 169.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40827.1 - 1.3e-16 60.7 0.0 1.9e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EKE40827.1 - 4e-05 23.7 0.0 6.6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EKE40827.1 - 0.0001 22.0 0.4 0.002 17.8 0.0 2.2 1 1 1 2 2 2 1 RIO1 family Choline_kinase PF01633.20 EKE40827.1 - 0.0066 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase ABC1 PF03109.16 EKE40827.1 - 0.17 12.1 0.0 0.39 10.9 0.0 1.5 1 0 0 1 1 1 0 ABC1 family TMEM154 PF15102.6 EKE40828.1 - 9.2e-05 22.4 0.7 0.0002 21.3 0.7 1.5 1 0 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 EKE40828.1 - 0.004 17.4 0.1 0.011 16.0 0.1 1.7 1 0 0 1 1 1 1 Orf78 (ac78) Peptidase_S41 PF03572.18 EKE40828.1 - 0.0041 16.7 0.0 0.009 15.6 0.0 1.6 1 0 0 1 1 1 1 Peptidase family S41 Rax2 PF12768.7 EKE40828.1 - 0.012 15.1 0.1 0.022 14.2 0.1 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity CARDB PF07705.11 EKE40828.1 - 0.032 14.5 2.0 9.9 6.5 0.2 3.5 3 0 0 3 3 3 0 CARDB Podoplanin PF05808.11 EKE40828.1 - 0.052 13.6 0.2 0.1 12.7 0.2 1.4 1 0 0 1 1 1 0 Podoplanin TRP PF06011.12 EKE40828.1 - 0.059 12.1 0.1 0.091 11.5 0.1 1.2 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel PRIMA1 PF16101.5 EKE40828.1 - 0.064 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 HisKA_4TM PF16926.5 EKE40828.1 - 0.31 10.6 1.0 0.57 9.7 1.0 1.3 1 0 0 1 1 1 0 Archaeal 4TM region of histidine kinase HSL_N PF06350.12 EKE40829.1 - 0.017 14.1 0.5 0.081 11.9 0.1 2.0 2 0 0 2 2 2 0 Hormone-sensitive lipase (HSL) N-terminus PEPcase_2 PF14010.6 EKE40829.1 - 0.045 12.3 1.6 0.071 11.6 1.6 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase DUF2203 PF09969.9 EKE40829.1 - 0.045 14.5 1.9 4.2 8.1 1.2 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Kri1 PF05178.12 EKE40829.1 - 0.091 13.3 3.9 2.4 8.8 1.7 2.4 1 1 1 2 2 2 0 KRI1-like family TraF_2 PF13729.6 EKE40829.1 - 0.12 11.8 0.2 0.18 11.1 0.2 1.4 1 0 0 1 1 1 0 F plasmid transfer operon, TraF, protein FapA PF03961.13 EKE40829.1 - 0.13 10.8 7.0 0.25 9.9 7.0 1.5 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF5364 PF17322.2 EKE40829.1 - 0.13 12.5 6.1 0.21 11.9 6.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5364) zf-AD PF07776.15 EKE40829.1 - 1.1 9.5 4.6 4.8 7.5 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) Rx_N PF18052.1 EKE40829.1 - 1.3 9.4 8.3 0.63 10.3 1.5 2.5 2 0 0 2 2 2 0 Rx N-terminal domain Snapin_Pallidin PF14712.6 EKE40829.1 - 1.5 9.3 7.8 6.2 7.3 0.3 2.6 2 0 0 2 2 2 0 Snapin/Pallidin DUF1664 PF07889.12 EKE40829.1 - 3.8 7.6 9.4 8.9 6.4 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4200 PF13863.6 EKE40829.1 - 7.1 7.1 18.3 11 6.5 11.5 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Coatomer_WDAD PF04053.14 EKE40830.1 - 1.4e-44 152.9 8.7 3.2e-42 145.1 6.3 2.2 1 1 0 2 2 2 2 Coatomer WD associated region WD40 PF00400.32 EKE40830.1 - 1.1e-37 127.3 13.5 2e-09 37.9 0.4 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE40830.1 - 1.2e-05 25.5 0.1 0.73 10.2 0.0 4.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EKE40830.1 - 0.15 10.6 2.1 17 3.9 0.0 4.0 4 1 1 5 5 5 0 Nucleoporin Nup120/160 ThiF PF00899.21 EKE40831.1 - 4.5e-57 193.2 0.3 5.4e-57 192.9 0.3 1.0 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.19 EKE40831.1 - 0.00019 20.8 0.2 0.00019 20.8 0.2 2.4 2 2 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EKE40831.1 - 0.014 15.4 0.1 0.029 14.4 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EKE40831.1 - 0.065 13.5 3.0 0.29 11.4 1.2 2.6 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain WD40 PF00400.32 EKE40832.1 - 5.5e-27 93.5 19.0 1.2e-08 35.4 1.7 6.7 6 1 0 6 6 6 4 WD domain, G-beta repeat NLE PF08154.12 EKE40832.1 - 5.5e-18 65.2 0.6 1.1e-17 64.3 0.6 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 EKE40832.1 - 5.6e-15 55.4 2.9 0.00075 19.7 0.1 5.4 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EKE40832.1 - 3.8e-07 30.2 1.9 0.19 11.6 0.0 3.2 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EKE40832.1 - 0.0013 18.2 0.9 3.3 6.9 0.1 3.5 1 1 2 3 3 3 2 WD40-like domain Ras PF00071.22 EKE40833.1 - 3.2e-07 30.1 0.4 5.8e-07 29.2 0.4 1.5 1 1 0 1 1 1 1 Ras family TPM_phosphatase PF04536.14 EKE40833.1 - 0.017 15.3 0.6 2.1 8.6 0.1 2.4 1 1 1 2 2 2 0 TPM domain Roc PF08477.13 EKE40833.1 - 0.053 13.7 0.1 0.053 13.7 0.1 1.9 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EKE40833.1 - 0.057 13.2 0.3 0.69 9.7 0.3 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 EKE40833.1 - 0.064 13.0 0.1 0.096 12.5 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein IML1 PF12257.8 EKE40834.1 - 2.3e-24 86.0 0.0 3.9e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EKE40834.1 - 0.00088 19.3 0.0 0.0022 18.0 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) R3H PF01424.22 EKE40835.1 - 5.2e-09 36.0 0.0 9.3e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 R3H domain RicinB_lectin_2 PF14200.6 EKE40836.1 - 8.2e-12 45.7 0.0 9.9e-05 23.0 0.0 2.9 1 1 2 3 3 3 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 EKE40836.1 - 5.3e-07 29.9 0.0 9.9e-07 29.1 0.0 1.4 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RNase_P_Rpp14 PF01900.19 EKE40837.1 - 0.037 14.3 0.0 0.041 14.1 0.0 1.1 1 0 0 1 1 1 0 Rpp14/Pop5 family RF3_C PF16658.5 EKE40837.1 - 0.077 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain SAM_2 PF07647.17 EKE40838.1 - 2e-05 24.6 0.2 0.00056 20.0 0.0 3.3 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EKE40838.1 - 9.1e-05 22.8 0.0 0.00035 20.9 0.0 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF1863 PF08937.11 EKE40838.1 - 0.019 15.3 3.6 0.02 15.2 0.0 2.7 3 0 0 3 3 3 0 MTH538 TIR-like domain (DUF1863) Fer4_NifH PF00142.18 EKE40838.1 - 0.095 12.1 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Metallophos PF00149.28 EKE40839.1 - 2.3e-35 123.0 0.0 4.3e-35 122.1 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase V-ATPase_C PF03223.15 EKE40840.1 - 2.8e-77 260.6 8.2 3.4e-77 260.4 8.2 1.0 1 0 0 1 1 1 1 V-ATPase subunit C Speriolin_C PF15059.6 EKE40840.1 - 0.044 13.9 1.0 11 6.2 0.0 2.4 2 0 0 2 2 2 0 Speriolin C-terminus PI3K_P85_iSH2 PF16454.5 EKE40840.1 - 0.053 13.1 0.4 1.3 8.6 0.0 2.4 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain RecC_C PF17946.1 EKE40840.1 - 0.082 12.7 0.0 0.41 10.4 0.0 1.9 2 0 0 2 2 2 0 RecC C-terminal domain MS_channel PF00924.18 EKE40841.1 - 1 8.9 2.9 1.9 8.0 2.9 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel Methyltransf_19 PF04672.12 EKE40842.1 - 0.0043 16.6 0.0 0.0069 15.9 0.0 1.2 1 0 0 1 1 1 1 S-adenosyl methyltransferase PrmA PF06325.13 EKE40842.1 - 0.097 12.0 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) RRM_1 PF00076.22 EKE40843.1 - 2.1e-16 59.5 0.2 3e-16 59.0 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) tRNA-synt_2b PF00587.25 EKE40844.1 - 1.4e-37 129.4 0.0 2.3e-37 128.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EKE40844.1 - 1.5e-19 70.2 5.3 3.8e-19 68.9 5.3 1.7 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 EKE40844.1 - 0.0036 16.0 1.8 0.0051 15.5 1.8 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A FlaC_arch PF05377.11 EKE40844.1 - 0.42 11.1 2.7 22 5.6 0.1 2.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Ras PF00071.22 EKE40848.1 - 1.2e-56 190.8 0.0 1.4e-56 190.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40848.1 - 8.7e-24 84.0 0.0 1.6e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40848.1 - 7e-09 35.4 0.0 9.3e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE40848.1 - 0.0063 15.9 0.0 0.017 14.5 0.0 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RRM_1 PF00076.22 EKE40849.1 - 7.7e-14 51.3 0.1 8.7e-06 25.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE40849.1 - 0.00019 21.4 0.1 0.0019 18.1 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_9 PF18444.1 EKE40849.1 - 0.017 15.0 0.1 0.5 10.2 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif PRP38_assoc PF12871.7 EKE40849.1 - 2.7 8.6 33.1 0.068 13.8 26.3 1.8 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term baeRF_family5 PF18846.1 EKE40849.1 - 6.1 7.0 8.1 0.57 10.4 2.1 2.2 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 5 Peptidase_S41 PF03572.18 EKE40850.1 - 0.0038 16.8 0.0 0.0067 16.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S41 LRR_5 PF13306.6 EKE40851.1 - 2.9e-126 415.2 87.2 1.1e-35 122.4 8.1 7.6 6 1 0 7 7 7 7 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE40851.1 - 1.4e-20 72.8 26.2 7.9e-06 25.5 0.2 11.5 8 3 5 13 13 13 9 Leucine rich repeat LRR_4 PF12799.7 EKE40851.1 - 7e-07 29.5 42.0 0.0096 16.3 0.5 11.3 9 2 0 10 10 10 5 Leucine Rich repeats (2 copies) Ras PF00071.22 EKE40852.1 - 1.4e-20 73.6 1.6 1.7e-20 73.2 1.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40852.1 - 6e-08 32.9 0.1 1e-07 32.2 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40852.1 - 1.1e-05 25.0 0.5 4.5e-05 23.0 0.5 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE40852.1 - 0.018 15.0 0.2 0.48 10.3 0.1 2.2 2 1 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 EKE40852.1 - 0.046 13.3 0.1 0.59 9.7 0.1 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain TniB PF05621.11 EKE40852.1 - 0.056 12.8 0.3 0.47 9.8 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein MeaB PF03308.16 EKE40852.1 - 0.13 11.2 0.1 0.23 10.4 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TPR_12 PF13424.6 EKE40853.1 - 2.7e-09 37.2 0.1 0.12 12.6 0.0 5.2 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EKE40853.1 - 3.8e-08 32.8 14.3 1.1 9.5 0.1 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 EKE40853.1 - 6.5e-07 29.1 26.7 0.007 16.5 1.5 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 EKE40853.1 - 0.012 15.4 23.7 0.52 10.2 0.8 6.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 EKE40853.1 - 0.064 13.3 0.5 44 4.4 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Nrap_D2 PF17403.2 EKE40853.1 - 0.16 11.8 0.5 1 9.1 0.1 2.3 2 0 0 2 2 2 0 Nrap protein PAP/OAS-like domain SNAP PF14938.6 EKE40853.1 - 0.16 11.4 5.4 0.44 9.9 0.7 3.0 2 1 1 3 3 3 0 Soluble NSF attachment protein, SNAP TPR_10 PF13374.6 EKE40853.1 - 0.22 11.4 0.4 98 3.0 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EKE40853.1 - 2.1 9.2 4.5 42 5.1 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat IBR PF01485.21 EKE40854.1 - 5.6e-20 71.3 36.2 1.8e-11 44.1 11.7 4.2 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EKE40854.1 - 0.0086 16.4 12.0 0.0086 16.4 12.0 5.6 2 2 3 5 5 5 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKE40854.1 - 0.0097 15.7 8.8 0.0097 15.7 8.8 5.8 4 2 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE40854.1 - 0.017 15.1 8.4 0.017 15.1 8.4 4.2 4 1 0 4 4 4 0 RING-type zinc-finger DUF2098 PF09871.9 EKE40854.1 - 4.1 7.8 8.7 10 6.5 8.7 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) TLD PF07534.16 EKE40855.1 - 2.7e-22 79.5 0.7 4.9e-22 78.6 0.7 1.4 1 0 0 1 1 1 1 TLD RabGAP-TBC PF00566.18 EKE40855.1 - 0.00045 20.0 1.3 0.0011 18.7 0.5 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF4473 PF14747.6 EKE40856.1 - 0.035 14.6 0.1 0.14 12.7 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) Got1 PF04178.12 EKE40857.1 - 2.8e-26 92.2 21.4 3.9e-26 91.7 21.4 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family MMS19_N PF14500.6 EKE40859.1 - 7.7e-48 163.3 4.8 7.7e-48 163.3 4.8 2.5 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II Mistic PF11458.8 EKE40859.1 - 0.0076 16.2 0.3 0.4 10.7 0.1 3.2 2 0 0 2 2 2 1 Membrane-integrating protein Mistic A_thal_3526 PF09713.10 EKE40859.1 - 0.022 15.0 1.0 2.7 8.3 0.2 3.4 2 0 0 2 2 2 0 Plant protein 1589 of unknown function (A_thal_3526) DAGK_acc PF00609.19 EKE40860.1 - 7e-33 114.2 0.0 1.1e-32 113.6 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EKE40860.1 - 7.9e-19 67.5 0.0 1.3e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 EKE40860.1 - 3.8e-18 65.1 49.3 3.5e-13 49.2 5.9 3.7 3 0 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EKE40860.1 - 0.0021 18.3 8.2 0.0021 18.3 8.2 3.9 4 1 0 4 4 4 2 C1 domain Zf_RING PF16744.5 EKE40860.1 - 0.027 14.6 35.4 0.037 14.1 3.2 4.1 4 0 0 4 4 4 0 KIAA1045 RING finger Ras PF00071.22 EKE40861.1 - 7e-48 162.3 0.2 8.5e-48 162.0 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40861.1 - 2.4e-30 105.2 0.0 3.7e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40861.1 - 1.5e-14 53.8 0.1 1.9e-14 53.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE40861.1 - 1.8e-08 34.2 0.1 2.2e-08 33.9 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE40861.1 - 1.7e-07 30.8 0.1 2.3e-07 30.4 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE40861.1 - 2e-05 24.6 0.0 3.3e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE40861.1 - 0.0036 17.2 0.4 0.21 11.5 0.0 2.3 1 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EKE40861.1 - 0.044 13.3 0.2 4.4 6.8 0.0 2.5 2 1 0 2 2 2 0 Ferrous iron transport protein B FHA PF00498.26 EKE40862.1 - 2.4e-06 27.8 0.2 4.9e-06 26.8 0.2 1.6 1 0 0 1 1 1 1 FHA domain DPBB_1 PF03330.18 EKE40863.1 - 0.00061 20.0 0.8 0.0014 18.8 0.1 2.1 2 0 0 2 2 2 1 Lytic transglycolase Pollen_allerg_1 PF01357.21 EKE40863.1 - 0.014 15.4 0.1 0.28 11.3 0.1 2.6 2 0 0 2 2 2 0 Pollen allergen MxiM PF11441.8 EKE40863.1 - 1.3 9.4 5.5 32 4.9 0.6 3.6 2 1 1 3 3 3 0 Pilot protein MxiM RhoGAP PF00620.27 EKE40864.1 - 3.8e-18 65.7 0.0 3.8e-18 65.7 0.0 2.3 3 0 0 3 3 3 1 RhoGAP domain Helicase_C_4 PF13871.6 EKE40864.1 - 0.004 16.9 1.2 0.0085 15.8 1.2 1.5 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue Nmad5 PF18757.1 EKE40864.1 - 0.0091 16.2 3.7 0.057 13.6 3.7 2.0 1 1 0 1 1 1 1 Nucleotide modification associated domain 5 Sacchrp_dh_C PF16653.5 EKE40864.1 - 0.085 12.9 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase C-terminal domain Ribosomal_L30_N PF08079.12 EKE40864.1 - 1.9 8.8 7.3 0.63 10.3 0.8 2.3 2 0 0 2 2 2 0 Ribosomal L30 N-terminal domain DUF4570 PF15134.6 EKE40864.1 - 2.6 8.1 5.6 0.3 11.1 1.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) DUF2070 PF09843.9 EKE40865.1 - 1.3 7.2 12.5 1.5 7.0 12.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MBOAT PF03062.19 EKE40866.1 - 3.9e-23 82.4 21.1 3.9e-23 82.4 21.1 1.6 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DEAD PF00270.29 EKE40867.1 - 2.8e-46 157.5 0.0 4.9e-46 156.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE40867.1 - 6.5e-30 103.7 0.0 1.8e-29 102.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE40867.1 - 8e-05 22.7 0.0 0.00017 21.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit NST1 PF13945.6 EKE40867.1 - 0.028 14.5 1.0 0.048 13.8 1.0 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Peptidase_M24 PF00557.24 EKE40868.1 - 1.1e-17 64.4 0.3 1.4e-17 64.1 0.3 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 APG9 PF04109.16 EKE40869.1 - 1.7e-06 27.4 0.5 1.8e-06 27.2 0.5 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 DUF3038 PF11237.8 EKE40869.1 - 0.039 14.0 0.5 0.06 13.4 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3038) Rab5ip PF07019.12 EKE40869.1 - 0.29 11.7 3.0 0.2 12.3 1.0 1.8 2 1 0 2 2 2 0 Rab5-interacting protein (Rab5ip) APG9 PF04109.16 EKE40870.1 - 1.6e-05 24.2 8.5 1.8e-05 24.0 8.2 1.3 1 1 0 1 1 1 1 Autophagy protein Apg9 ASFV_J13L PF05568.11 EKE40870.1 - 1.8 8.3 3.3 2.3 8.0 0.2 2.1 2 0 0 2 2 2 0 African swine fever virus J13L protein Glu_cyclase_2 PF05096.12 EKE40871.1 - 5.2e-71 239.0 0.4 6.1e-71 238.8 0.4 1.0 1 0 0 1 1 1 1 Glutamine cyclotransferase Lgl_C PF08596.10 EKE40871.1 - 0.0089 14.8 0.0 0.012 14.3 0.0 1.1 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal RRM_1 PF00076.22 EKE40872.1 - 6.8e-09 35.4 0.0 1.3e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EKE40872.1 - 0.0032 17.6 0.1 0.0047 17.0 0.1 1.6 1 1 0 1 1 1 1 RNA recognition motif DUF4672 PF15716.5 EKE40874.1 - 0.2 11.3 1.7 0.2 11.3 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) LRR_5 PF13306.6 EKE40875.1 - 1.3e-64 216.0 29.3 2e-33 115.1 5.8 4.2 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE40875.1 - 3.4e-14 52.3 9.2 0.022 14.5 0.1 7.1 3 2 5 8 8 8 6 Leucine rich repeat SOCS_box PF07525.16 EKE40875.1 - 9.4 6.7 9.1 9 6.8 0.9 4.0 3 2 1 4 4 4 0 SOCS box Thioredoxin PF00085.20 EKE40876.1 - 1.2e-09 38.0 4.9 8.2e-07 29.0 0.2 3.2 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_2 PF13098.6 EKE40876.1 - 0.0059 17.0 0.5 0.0059 17.0 0.5 4.1 4 1 0 4 4 4 1 Thioredoxin-like domain HSP70 PF00012.20 EKE40877.1 - 2.5e-108 362.8 19.1 5.3e-97 325.4 7.0 2.2 1 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EKE40877.1 - 2.7e-19 69.1 7.5 8.3e-19 67.6 5.9 2.4 2 1 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EKE40877.1 - 5.8e-05 23.5 10.5 0.00037 20.9 1.5 3.6 2 2 1 3 3 3 2 Cell division protein FtsA BcrAD_BadFG PF01869.20 EKE40877.1 - 0.0025 17.3 0.1 0.078 12.5 0.0 2.6 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family TrwC PF08751.11 EKE40877.1 - 0.021 14.4 0.3 0.021 14.4 0.3 2.1 3 0 0 3 3 3 0 TrwC relaxase Hydantoinase_A PF01968.18 EKE40877.1 - 0.051 12.8 0.1 0.18 11.0 0.1 1.9 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Sec20 PF03908.13 EKE40877.1 - 0.084 12.8 1.9 0.39 10.6 1.9 2.1 1 0 0 1 1 1 0 Sec20 Mut7-C PF01927.16 EKE40877.1 - 0.99 9.5 3.2 0.63 10.1 0.3 2.1 2 0 0 2 2 2 0 Mut7-C RNAse domain PI3_PI4_kinase PF00454.27 EKE40878.1 - 1e-10 41.9 3.8 1.8e-09 37.8 0.8 3.1 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Fe-ADH PF00465.19 EKE40879.1 - 7.8e-77 258.5 0.0 9.5e-77 258.3 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EKE40879.1 - 1.7e-06 27.9 0.4 2e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 EKE40879.1 - 0.46 9.6 2.4 16 4.5 0.7 2.4 2 1 0 2 2 2 0 3-dehydroquinate synthase zf-C2H2 PF00096.26 EKE40880.1 - 1.9e-22 78.4 46.0 0.00018 21.8 1.1 7.4 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EKE40880.1 - 3.4e-16 58.6 47.2 0.003 18.3 0.6 7.5 7 0 0 7 7 7 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EKE40880.1 - 5.2e-10 39.3 52.1 0.00012 22.3 1.2 8.5 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2_3rep PF18868.1 EKE40880.1 - 3.3e-06 27.8 26.6 0.27 11.9 2.7 5.2 1 1 3 5 5 5 5 Zinc finger C2H2-type, 3 repeats zf-Di19 PF05605.12 EKE40880.1 - 8.8e-06 25.9 46.5 0.34 11.2 0.3 6.6 3 2 1 6 6 6 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 EKE40880.1 - 0.00031 21.0 23.9 0.017 15.4 7.1 3.3 1 1 2 3 3 3 2 C2H2-type zinc ribbon TF_Zn_Ribbon PF08271.12 EKE40880.1 - 0.013 15.0 11.1 0.023 14.2 1.0 4.1 3 1 0 3 3 3 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EKE40880.1 - 0.021 14.9 2.9 0.021 14.9 2.9 4.1 2 2 2 4 4 3 0 Zinc ribbon domain zf-ACC PF17848.1 EKE40880.1 - 0.044 13.9 0.0 0.044 13.9 0.0 4.4 4 0 0 4 4 3 0 Acetyl-coA carboxylase zinc finger domain zf_UBZ PF18439.1 EKE40880.1 - 0.051 13.2 13.0 0.83 9.3 0.1 4.4 4 0 0 4 4 3 0 Ubiquitin-Binding Zinc Finger zf-IS66 PF13005.7 EKE40880.1 - 0.16 12.4 6.1 3.5 8.1 0.1 3.8 3 0 0 3 3 3 0 zinc-finger binding domain of transposase IS66 ARS2 PF04959.13 EKE40880.1 - 0.17 12.2 0.4 0.17 12.2 0.4 4.4 1 1 3 4 4 4 0 Arsenite-resistance protein 2 zf-C2H2_11 PF16622.5 EKE40880.1 - 0.2 11.5 0.3 0.2 11.5 0.3 4.3 6 0 0 6 6 5 0 zinc-finger C2H2-type FOXP-CC PF16159.5 EKE40880.1 - 0.36 11.5 26.5 2.5 8.8 1.3 6.2 1 1 6 7 7 7 0 FOXP coiled-coil domain DUF1610 PF07754.11 EKE40880.1 - 0.39 10.7 0.1 0.39 10.7 0.1 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF1610) PhnJ PF06007.11 EKE40880.1 - 0.49 9.3 5.4 0.27 10.2 1.3 2.4 1 1 0 2 2 2 0 Phosphonate metabolism protein PhnJ DUF2197 PF09963.9 EKE40880.1 - 0.54 10.6 7.9 2.2 8.6 1.6 2.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-C2H2_aberr PF17017.5 EKE40880.1 - 0.58 10.3 31.1 0.51 10.5 8.0 4.1 2 2 2 4 4 4 0 Aberrant zinc-finger DUF733 PF05306.11 EKE40880.1 - 1.2 9.5 5.9 8.9 6.7 1.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF733) zf-C2H2_jaz PF12171.8 EKE40880.1 - 1.8 9.0 0.0 1.8 9.0 0.0 5.3 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EKE40880.1 - 2.9 7.7 25.1 0.62 9.9 1.1 6.0 5 1 0 5 5 5 0 C2H2-type zinc-finger domain zf-ribbon_3 PF13248.6 EKE40880.1 - 4.8 6.7 17.3 1.5 8.4 0.2 4.2 4 0 0 4 4 3 0 zinc-ribbon domain OTOS PF15182.6 EKE40881.1 - 0.083 12.8 1.0 0.8 9.7 0.3 2.5 2 0 0 2 2 2 0 Otospiralin TIP49 PF06068.13 EKE40882.1 - 2.5e-144 480.8 0.7 3.2e-144 480.5 0.7 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EKE40882.1 - 4.6e-18 65.1 0.2 1.1e-17 63.9 0.2 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EKE40882.1 - 1e-11 45.3 0.3 7.2e-08 32.9 0.1 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EKE40882.1 - 3.8e-11 43.0 0.1 1.6e-07 31.2 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EKE40882.1 - 1.8e-08 34.7 0.1 0.011 16.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EKE40882.1 - 2.5e-08 34.5 0.2 1e-06 29.2 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EKE40882.1 - 1.4e-06 28.3 0.1 0.0031 17.5 0.0 3.0 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EKE40882.1 - 3.1e-05 24.5 0.0 7.4e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EKE40882.1 - 3.6e-05 23.3 0.4 0.0034 16.8 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EKE40882.1 - 0.00019 21.7 0.0 0.00034 20.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKE40882.1 - 0.00021 21.7 0.1 0.25 11.7 0.1 2.5 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 EKE40882.1 - 0.00044 19.7 0.1 0.0008 18.8 0.1 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Sigma54_activat PF00158.26 EKE40882.1 - 0.00056 19.6 0.1 0.23 11.2 0.1 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 EKE40882.1 - 0.001 19.1 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EKE40882.1 - 0.0012 18.2 0.1 0.0021 17.4 0.1 1.3 1 0 0 1 1 1 1 Zeta toxin TsaE PF02367.17 EKE40882.1 - 0.0013 18.8 0.1 0.0078 16.2 0.1 2.1 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EKE40882.1 - 0.0018 18.2 0.0 0.0038 17.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 EKE40882.1 - 0.0021 17.7 0.1 0.004 16.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain PIF1 PF05970.14 EKE40882.1 - 0.0023 17.1 0.0 0.54 9.4 0.0 2.2 2 0 0 2 2 2 1 PIF1-like helicase AAA_33 PF13671.6 EKE40882.1 - 0.0034 17.5 0.0 0.011 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EKE40882.1 - 0.0052 17.2 0.3 0.033 14.6 0.0 2.4 3 0 0 3 3 3 1 AAA domain ResIII PF04851.15 EKE40882.1 - 0.0058 16.7 0.4 1.3 9.0 0.1 2.5 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 EKE40882.1 - 0.0075 16.6 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_3 PF07726.11 EKE40882.1 - 0.01 15.7 0.0 0.03 14.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EKE40882.1 - 0.012 15.1 0.0 0.05 13.1 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 EKE40882.1 - 0.018 14.7 0.3 0.44 10.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_32 PF13654.6 EKE40882.1 - 0.021 13.7 0.3 0.45 9.2 0.0 2.5 2 1 1 3 3 3 0 AAA domain IstB_IS21 PF01695.17 EKE40882.1 - 0.021 14.6 0.1 0.042 13.6 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EKE40882.1 - 0.023 14.1 0.0 0.087 12.2 0.0 2.0 2 0 0 2 2 2 0 KaiC DUF815 PF05673.13 EKE40882.1 - 0.024 13.8 0.1 0.049 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TniB PF05621.11 EKE40882.1 - 0.028 13.9 0.8 0.6 9.5 0.0 2.5 3 0 0 3 3 2 0 Bacterial TniB protein PduV-EutP PF10662.9 EKE40882.1 - 0.05 13.3 0.4 0.17 11.6 0.1 2.1 2 1 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation DUF853 PF05872.12 EKE40882.1 - 0.062 11.9 0.1 0.062 11.9 0.1 1.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) Rad17 PF03215.15 EKE40882.1 - 0.062 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain Parvo_NS1 PF01057.17 EKE40882.1 - 0.083 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF2075 PF09848.9 EKE40882.1 - 0.11 11.7 0.8 0.12 11.6 0.0 1.4 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 EKE40882.1 - 0.13 11.9 0.0 2.2 8.0 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Spy1 PF11357.8 EKE40884.1 - 0.071 13.4 1.0 0.088 13.1 1.0 1.2 1 0 0 1 1 1 0 Cell cycle regulatory protein LSM PF01423.22 EKE40885.1 - 5.6e-17 61.2 0.0 6.4e-17 61.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain IMS PF00817.20 EKE40887.1 - 0.0023 17.9 0.1 0.0025 17.8 0.1 1.1 1 0 0 1 1 1 1 impB/mucB/samB family DUF4596 PF15363.6 EKE40887.1 - 0.09 13.0 3.2 0.96 9.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4596) PIF1 PF05970.14 EKE40889.1 - 1.3e-53 182.5 7.0 4.9e-45 154.3 0.7 3.0 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EKE40889.1 - 1.3e-19 70.7 0.0 1.9e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKE40889.1 - 5.8e-09 36.4 0.0 1.2e-08 35.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKE40889.1 - 0.0041 17.4 0.1 0.019 15.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EKE40889.1 - 0.025 15.0 0.1 0.063 13.7 0.1 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EKE40889.1 - 0.032 14.6 0.2 0.17 12.2 0.2 2.4 1 1 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 EKE40889.1 - 0.035 14.1 0.3 0.21 11.6 0.3 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EKE40889.1 - 0.036 13.5 0.3 0.081 12.3 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 EKE40889.1 - 0.038 13.5 0.0 0.097 12.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EKE40889.1 - 0.07 13.0 0.1 0.22 11.4 0.1 1.8 1 0 0 1 1 1 0 NACHT domain ResIII PF04851.15 EKE40889.1 - 0.077 13.0 1.5 0.22 11.5 0.1 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit SH3_13 PF18335.1 EKE40889.1 - 0.087 12.7 0.0 0.41 10.5 0.0 2.2 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain PhoH PF02562.16 EKE40889.1 - 0.14 11.6 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Helicase_RecD PF05127.14 EKE40889.1 - 1.1 9.1 2.8 1.5 8.7 0.2 2.5 2 1 0 2 2 2 0 Helicase FliC_SP PF12613.8 EKE40889.1 - 6.2 7.4 7.3 0.2 12.2 0.6 2.0 2 0 0 2 2 1 0 Flagellin structural protein SK_channel PF03530.14 EKE40890.1 - 1.3 9.0 6.9 3 7.9 6.9 1.8 1 1 0 1 1 1 0 Calcium-activated SK potassium channel Ras PF00071.22 EKE40891.1 - 2.3e-51 173.6 0.1 2.8e-51 173.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40891.1 - 5.3e-30 104.1 0.0 9.2e-30 103.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40891.1 - 7.2e-11 41.8 0.0 8.4e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE40891.1 - 1.2e-06 28.5 0.0 2e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE40891.1 - 2e-06 27.4 0.0 2.7e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE40891.1 - 2.3e-06 27.3 0.0 0.00013 21.6 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE40891.1 - 1.2e-05 25.3 0.0 0.0025 17.7 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EKE40891.1 - 0.0008 19.8 0.0 0.0016 18.9 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 EKE40891.1 - 0.0015 18.0 0.0 0.002 17.6 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Septin PF00735.18 EKE40891.1 - 0.01 15.1 0.2 0.024 13.9 0.0 1.7 2 0 0 2 2 2 0 Septin ATPase_2 PF01637.18 EKE40891.1 - 0.014 15.4 0.1 0.048 13.6 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 EKE40891.1 - 0.014 15.4 0.0 0.046 13.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EKE40891.1 - 0.015 15.0 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 EKE40891.1 - 0.015 14.8 0.0 1 8.9 0.0 2.5 2 1 0 2 2 2 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EKE40891.1 - 0.022 14.6 0.1 5.2 6.8 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 EKE40891.1 - 0.022 14.7 0.1 0.045 13.7 0.0 1.5 2 0 0 2 2 1 0 NACHT domain AAA_22 PF13401.6 EKE40891.1 - 0.027 14.7 0.0 0.055 13.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EKE40891.1 - 0.046 13.2 0.1 0.082 12.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 EKE40891.1 - 0.063 13.0 0.1 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EKE40891.1 - 0.066 12.8 0.1 0.16 11.5 0.1 1.9 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EKE40891.1 - 0.075 13.5 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter TniB PF05621.11 EKE40891.1 - 0.083 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_28 PF13521.6 EKE40891.1 - 0.095 12.9 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 EKE40891.1 - 0.095 11.8 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 MCM P-loop domain RNA_helicase PF00910.22 EKE40891.1 - 0.099 13.0 0.0 0.2 12.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase PRK PF00485.18 EKE40891.1 - 0.1 12.3 0.1 0.66 9.7 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 EKE40891.1 - 0.11 11.7 0.2 0.17 11.1 0.1 1.4 2 0 0 2 2 2 0 NB-ARC domain AAA_14 PF13173.6 EKE40891.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ribosomal_L7Ae PF01248.26 EKE40892.1 - 4.3e-22 77.7 0.1 5.1e-22 77.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family zf-HIT PF04438.16 EKE40893.1 - 7.8e-11 41.6 13.4 1.5e-10 40.7 13.4 1.4 1 0 0 1 1 1 1 HIT zinc finger YL1_C PF08265.11 EKE40893.1 - 0.018 14.8 0.2 0.025 14.3 0.2 1.3 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain C1_2 PF03107.16 EKE40893.1 - 1.4 9.3 12.2 3.7 8.0 12.2 1.8 1 1 0 1 1 1 0 C1 domain ALMT PF11744.8 EKE40893.1 - 6.2 5.5 9.7 6.4 5.5 9.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA PF00004.29 EKE40895.1 - 5.8e-10 39.7 0.1 1.7e-09 38.2 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EKE40895.1 - 1.2e-08 35.5 0.1 1.3e-07 32.1 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EKE40895.1 - 1.7e-08 34.8 0.0 3.7e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EKE40895.1 - 3.6e-05 23.7 0.0 6.3e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Viral_helicase1 PF01443.18 EKE40895.1 - 0.00061 19.6 0.1 0.0015 18.3 0.0 1.6 1 1 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 EKE40895.1 - 0.00084 19.4 0.4 0.0021 18.1 0.3 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKE40895.1 - 0.00096 19.5 0.0 0.0028 18.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EKE40895.1 - 0.0015 17.8 0.0 0.0061 15.8 0.0 2.1 2 0 0 2 2 2 1 NB-ARC domain AFG1_ATPase PF03969.16 EKE40895.1 - 0.0026 16.7 0.0 0.0032 16.4 0.0 1.2 1 0 0 1 1 1 1 AFG1-like ATPase ATPase_2 PF01637.18 EKE40895.1 - 0.003 17.5 5.1 0.011 15.7 2.4 2.6 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_33 PF13671.6 EKE40895.1 - 0.006 16.8 0.0 0.011 15.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 EKE40895.1 - 0.0063 16.0 0.1 0.014 14.8 0.1 1.6 1 1 0 1 1 1 1 Bacterial TniB protein Sigma54_activat PF00158.26 EKE40895.1 - 0.0082 15.9 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_24 PF13479.6 EKE40895.1 - 0.012 15.4 0.1 0.038 13.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain DUF5016 PF16408.5 EKE40895.1 - 0.025 14.6 0.1 0.052 13.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5016) Rad17 PF03215.15 EKE40895.1 - 0.046 13.6 6.6 0.29 11.1 0.0 3.2 2 2 1 3 3 3 0 Rad17 P-loop domain AAA_18 PF13238.6 EKE40895.1 - 0.047 14.2 0.0 0.097 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EKE40895.1 - 0.049 13.5 1.6 1.3 8.9 1.5 2.8 1 1 0 1 1 1 0 NTPase Herpes_US9 PF06072.11 EKE40895.1 - 0.054 13.4 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 DUF1796 PF08795.10 EKE40895.1 - 0.069 13.1 0.5 0.38 10.7 0.1 2.1 2 0 0 2 2 2 0 Putative papain-like cysteine peptidase (DUF1796) TsaE PF02367.17 EKE40895.1 - 0.07 13.1 0.0 0.38 10.8 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EKE40895.1 - 0.093 13.1 0.1 0.75 10.2 0.0 2.6 2 0 0 2 2 2 0 RNA helicase SPATA24 PF15175.6 EKE40895.1 - 0.2 11.5 2.0 0.41 10.5 0.1 2.3 3 0 0 3 3 3 0 Spermatogenesis-associated protein 24 AAA_23 PF13476.6 EKE40895.1 - 4.3 7.8 8.8 30 5.0 8.5 2.7 1 1 0 1 1 1 0 AAA domain Copine PF07002.16 EKE40896.1 - 1.3e-62 211.1 0.0 1.6e-62 210.8 0.0 1.1 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EKE40896.1 - 9.1e-10 39.0 0.0 1.7e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EKE40896.1 - 0.0007 19.9 0.0 0.0011 19.2 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Asn_synthase PF00733.21 EKE40897.1 - 2e-16 60.6 0.0 5.4e-13 49.3 0.0 2.6 1 1 1 2 2 2 2 Asparagine synthase QueC PF06508.13 EKE40897.1 - 0.031 13.8 0.0 0.074 12.5 0.0 1.6 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC NT-C2 PF10358.9 EKE40898.1 - 2e-15 56.8 0.4 2e-15 56.8 0.4 2.7 3 1 0 3 3 3 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 EKE40898.1 - 0.00014 22.1 1.7 0.00019 21.7 0.3 2.0 2 0 0 2 2 2 1 DIL domain GFO_IDH_MocA PF01408.22 EKE40900.1 - 7.7e-15 55.8 0.0 1.4e-14 54.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.20 EKE40900.1 - 0.13 12.4 0.0 1.2 9.2 0.0 2.3 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Abhydrolase_1 PF00561.20 EKE40901.1 - 0.002 17.8 0.0 0.0052 16.5 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold HTH_22 PF13309.6 EKE40902.1 - 0.0042 17.1 0.1 0.0091 16.1 0.1 1.6 1 0 0 1 1 1 1 HTH domain Tyr_Deacylase PF02580.16 EKE40902.1 - 0.048 14.2 0.4 0.081 13.4 0.4 1.4 1 1 0 1 1 1 0 D-Tyr-tRNA(Tyr) deacylase PCI PF01399.27 EKE40903.1 - 0.0021 18.5 0.1 0.0033 17.9 0.0 1.4 2 0 0 2 2 2 1 PCI domain ThiF PF00899.21 EKE40905.1 - 4.4e-17 62.2 0.0 1.1e-16 60.9 0.0 1.6 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 EKE40905.1 - 3.5e-05 23.9 1.5 2.1 8.6 0.0 4.6 4 1 0 4 4 4 2 Ubiquitin-activating enzyme E1 four-helix bundle DUF956 PF06115.11 EKE40905.1 - 0.047 13.4 0.9 3.2 7.5 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF956) Ank_2 PF12796.7 EKE40906.1 - 5.2e-77 254.5 16.2 4.4e-12 46.4 0.3 7.8 1 1 9 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE40906.1 - 3.4e-57 190.1 5.8 9.1e-08 32.5 0.0 11.6 7 3 5 12 12 12 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE40906.1 - 2.9e-48 161.3 5.7 1.9e-10 40.8 0.1 11.0 9 3 4 13 13 13 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE40906.1 - 3.1e-48 156.1 0.9 0.008 16.6 0.0 15.3 15 0 0 15 15 15 11 Ankyrin repeat Ank PF00023.30 EKE40906.1 - 1.1e-43 145.8 2.3 0.0054 17.1 0.0 14.3 15 0 0 15 15 15 10 Ankyrin repeat SH3_9 PF14604.6 EKE40906.1 - 1.5e-05 24.8 0.0 3.4e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EKE40906.1 - 0.00025 20.6 0.1 0.00071 19.2 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EKE40906.1 - 0.0068 16.0 0.1 0.013 15.1 0.1 1.5 1 0 0 1 1 1 1 SH3 domain DUF1664 PF07889.12 EKE40907.1 - 0.013 15.6 9.4 0.013 15.6 9.4 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) FYVE PF01363.21 EKE40907.1 - 0.03 14.5 6.8 0.04 14.0 5.3 2.0 2 0 0 2 2 2 0 FYVE zinc finger Cnn_1N PF07989.11 EKE40907.1 - 0.38 11.0 30.9 0.62 10.3 8.7 3.7 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DZR PF12773.7 EKE40907.1 - 0.41 10.7 7.5 0.38 10.8 3.4 2.1 1 1 1 2 2 2 0 Double zinc ribbon NYD-SP28_assoc PF14775.6 EKE40907.1 - 0.6 10.3 4.9 2.2 8.5 3.8 2.6 2 0 0 2 2 2 0 Sperm tail C-terminal domain C1_1 PF00130.22 EKE40907.1 - 0.71 9.8 6.5 2.6 8.0 6.5 2.0 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ATG16 PF08614.11 EKE40907.1 - 3 8.0 34.0 0.25 11.5 19.4 2.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) zf-C2HC_2 PF13913.6 EKE40907.1 - 7.6 6.6 11.1 0.48 10.4 0.3 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Aminotran_5 PF00266.19 EKE40908.1 - 1.4e-76 257.8 0.0 1.8e-76 257.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EKE40908.1 - 7.2e-08 32.0 0.0 8.7e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EKE40908.1 - 4.2e-07 29.5 0.0 4.2e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EKE40908.1 - 0.00012 21.5 0.1 0.00032 20.1 0.1 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family GDC-P PF02347.16 EKE40908.1 - 0.019 13.8 0.1 0.028 13.3 0.1 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein DUF459 PF04311.13 EKE40908.1 - 0.022 13.8 0.0 0.034 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF459) ELM2 PF01448.24 EKE40909.1 - 0.092 13.5 0.1 0.37 11.6 0.1 1.9 1 1 0 1 1 1 0 ELM2 domain LCAT PF02450.15 EKE40910.1 - 1.5e-36 126.5 0.0 1.1e-34 120.3 0.0 2.0 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase Lipase_2 PF01674.18 EKE40910.1 - 0.00043 19.9 0.1 0.0014 18.1 0.1 1.9 2 1 1 3 3 3 1 Lipase (class 2) Hydrolase_4 PF12146.8 EKE40910.1 - 0.0025 17.1 0.0 0.0038 16.5 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EKE40910.1 - 0.0033 17.2 0.0 0.027 14.2 0.0 2.3 3 0 0 3 3 3 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EKE40910.1 - 0.0047 17.6 0.0 0.0067 17.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EKE40910.1 - 0.0082 15.7 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase DUF676 PF05057.14 EKE40910.1 - 0.017 14.6 0.0 0.043 13.3 0.0 1.7 1 1 0 1 1 1 0 Putative serine esterase (DUF676) DUF900 PF05990.12 EKE40910.1 - 0.02 14.4 0.0 0.028 13.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF4809 PF16067.5 EKE40911.1 - 0.26 11.5 6.7 0.44 10.7 0.4 2.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4809) Myb_DNA-binding PF00249.31 EKE40912.1 - 2.8e-11 43.4 0.2 3.9e-11 43.0 0.2 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE40912.1 - 0.0049 17.1 0.0 0.0075 16.5 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EKE40912.1 - 0.022 14.7 0.8 0.033 14.1 0.8 1.2 1 0 0 1 1 1 0 Myb DNA-binding like CH PF00307.31 EKE40914.1 - 2.8e-28 98.3 3.3 4.6e-15 55.7 0.1 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain Fez1 PF06818.15 EKE40914.1 - 0.00072 20.1 36.5 0.00072 20.1 36.5 3.4 1 1 1 3 3 3 1 Fez1 AAA_13 PF13166.6 EKE40914.1 - 0.00091 18.0 39.5 0.00091 18.0 39.5 2.2 1 1 1 2 2 2 2 AAA domain CAMSAP_CH PF11971.8 EKE40914.1 - 0.0036 17.1 0.4 5.7 6.9 0.1 3.2 3 0 0 3 3 3 2 CAMSAP CH domain DUF1664 PF07889.12 EKE40914.1 - 0.0049 16.9 31.7 0.2 11.7 1.3 4.2 1 1 4 5 5 5 3 Protein of unknown function (DUF1664) HBM PF16591.5 EKE40914.1 - 0.069 12.6 17.5 0.17 11.3 1.7 2.8 1 1 1 2 2 2 0 Helical bimodular sensor domain Laminin_II PF06009.12 EKE40914.1 - 0.08 13.0 34.2 0.87 9.6 13.0 3.2 1 1 2 3 3 3 0 Laminin Domain II DUF2968 PF11180.8 EKE40914.1 - 0.19 11.3 22.9 0.017 14.7 5.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) ATG16 PF08614.11 EKE40914.1 - 0.59 10.3 48.4 0.033 14.4 15.4 3.9 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 EKE40914.1 - 0.61 10.2 59.4 0.077 13.1 6.7 4.2 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 EKE40914.1 - 0.68 7.4 44.7 2.1 5.7 20.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) TolA_bind_tri PF16331.5 EKE40914.1 - 0.81 9.8 41.3 1.8 8.7 15.6 5.3 2 2 2 4 4 4 0 TolA binding protein trimerisation NPV_P10 PF05531.12 EKE40914.1 - 1.5 9.3 18.0 9.4 6.8 4.7 4.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein HemX PF04375.14 EKE40914.1 - 2 7.6 32.5 0.33 10.2 4.9 3.4 1 1 2 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF3450 PF11932.8 EKE40914.1 - 2.2 7.5 38.3 2 7.6 10.8 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Serine_rich PF08824.10 EKE40914.1 - 2.4 8.2 13.6 0.29 11.1 5.8 2.3 2 0 0 2 2 2 0 Serine rich protein interaction domain Spc7 PF08317.11 EKE40914.1 - 4 6.2 61.8 0.4 9.5 23.0 3.1 1 1 1 3 3 3 0 Spc7 kinetochore protein DUF4407 PF14362.6 EKE40914.1 - 4.5 6.5 31.5 3.5e+02 0.3 31.5 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Beta_helix PF13229.6 EKE40915.1 - 1e-30 106.7 29.5 1e-16 61.2 9.3 2.7 1 1 2 3 3 3 3 Right handed beta helix region NosD PF05048.13 EKE40915.1 - 1.4e-21 76.9 8.9 5.3e-12 45.5 1.4 3.0 1 1 2 3 3 3 3 Periplasmic copper-binding protein (NosD) Pectate_lyase_3 PF12708.7 EKE40915.1 - 4.4e-05 23.4 9.8 0.00044 20.2 0.4 3.8 2 2 1 3 3 3 2 Pectate lyase superfamily protein S1_2 PF13509.6 EKE40915.1 - 0.05 13.7 0.0 18 5.5 0.0 3.7 4 0 0 4 4 4 0 S1 domain NlpE_C PF17185.4 EKE40915.1 - 0.12 12.7 0.1 9.4 6.6 0.0 3.0 3 0 0 3 3 3 0 NlpE C-terminal OB domain DUF4957 PF16318.5 EKE40915.1 - 1.3 9.0 16.5 0.37 10.7 6.3 3.9 1 1 0 3 3 3 0 Domain of unknown function (DUF4957) Pkinase_Tyr PF07714.17 EKE40916.1 - 4.9e-54 183.3 0.0 8e-54 182.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40916.1 - 1.1e-45 156.1 0.0 2.4e-44 151.7 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE40916.1 - 0.0023 16.8 0.0 0.0046 15.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Motile_Sperm PF00635.26 EKE40916.1 - 0.0026 17.6 0.0 0.0072 16.2 0.0 1.8 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF996 PF06195.13 EKE40916.1 - 0.063 13.6 0.3 0.15 12.4 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF996) Kdo PF06293.14 EKE40916.1 - 0.089 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SieB PF14163.6 EKE40916.1 - 0.17 11.4 1.5 0.86 9.1 1.5 2.2 1 0 0 1 1 1 0 Super-infection exclusion protein B CoaE PF01121.20 EKE40917.1 - 3.4e-37 127.8 0.2 4.2e-37 127.5 0.2 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 EKE40917.1 - 1.4e-05 25.6 0.3 3.1e-05 24.5 0.3 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EKE40917.1 - 0.0044 17.2 0.0 0.0074 16.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EKE40917.1 - 0.008 16.4 0.1 0.015 15.5 0.1 1.7 1 1 0 1 1 1 1 AAA domain Tim44 PF04280.15 EKE40917.1 - 0.025 14.7 0.8 0.055 13.6 0.7 1.7 1 1 0 1 1 1 0 Tim44-like domain Pkinase PF00069.25 EKE40919.1 - 2.7e-69 233.5 0.0 3.3e-69 233.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE40919.1 - 6.2e-37 127.3 0.0 8.7e-37 126.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE40919.1 - 4.1e-06 26.3 0.0 7.1e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EKE40919.1 - 2e-05 23.7 0.4 3.7e-05 22.9 0.4 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EKE40919.1 - 0.013 15.4 0.4 0.38 10.6 0.2 2.5 2 1 0 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EKE40919.1 - 0.014 14.2 2.1 0.014 14.2 2.1 2.0 2 1 1 3 3 3 0 Fungal protein kinase R-HINP1I PF11463.8 EKE40919.1 - 0.025 14.0 0.0 0.053 13.0 0.0 1.5 1 0 0 1 1 1 0 R.HinP1I restriction endonuclease ABC1 PF03109.16 EKE40919.1 - 0.15 12.2 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 ABC1 family RAMP4 PF06624.12 EKE40920.1 - 0.17 11.9 0.5 0.61 10.2 0.5 1.8 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 DUF758 PF05527.11 EKE40921.1 - 1.5e-39 135.9 2.9 2.2e-39 135.3 2.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF758) PH PF00169.29 EKE40921.1 - 6.3e-09 36.3 0.2 1.4e-08 35.2 0.2 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EKE40921.1 - 0.0019 18.6 2.4 0.0024 18.3 0.8 2.0 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EKE40921.1 - 0.0069 16.6 0.0 0.018 15.3 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain DUF4290 PF14123.6 EKE40921.1 - 0.068 12.7 0.8 0.15 11.6 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4290) SRI PF08236.11 EKE40921.1 - 0.27 11.4 4.5 0.5 10.6 0.4 2.8 2 1 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain EAP30 PF04157.16 EKE40922.1 - 3.5e-21 75.6 0.1 4e-21 75.4 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family MarR PF01047.22 EKE40922.1 - 0.011 15.6 0.1 0.021 14.7 0.1 1.4 1 0 0 1 1 1 0 MarR family Rrf2 PF02082.20 EKE40922.1 - 0.033 14.5 0.0 0.071 13.5 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator Penicillinase_R PF03965.16 EKE40922.1 - 0.063 13.6 0.2 0.4 11.1 0.0 2.1 2 0 0 2 2 2 0 Penicillinase repressor DUF5598 PF18127.1 EKE40922.1 - 0.38 11.2 3.2 2 8.9 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5598) DDRGK PF09756.9 EKE40922.1 - 0.46 10.0 5.2 5.9 6.4 0.0 2.7 2 1 1 3 3 3 0 DDRGK domain Hydrolase_4 PF12146.8 EKE40923.1 - 3.3e-37 128.0 0.0 3.8e-37 127.8 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EKE40923.1 - 6.3e-13 49.0 0.2 5.1e-08 32.9 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKE40923.1 - 1.3e-11 45.6 0.0 1.5e-11 45.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EKE40923.1 - 6.7e-08 32.3 0.4 0.0035 16.8 0.2 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_5 PF12695.7 EKE40923.1 - 1.4e-06 28.2 0.2 0.0019 18.0 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family DUF676 PF05057.14 EKE40923.1 - 0.0012 18.4 0.1 0.0034 16.9 0.0 1.7 2 0 0 2 2 2 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EKE40923.1 - 0.0026 17.5 0.7 0.0046 16.7 0.1 1.7 2 0 0 2 2 2 1 PGAP1-like protein Thioesterase PF00975.20 EKE40923.1 - 0.0028 17.8 0.0 0.0052 16.9 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 EKE40923.1 - 0.0035 17.2 0.0 0.01 15.7 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) DLH PF01738.18 EKE40923.1 - 0.0038 16.8 0.1 1.5 8.3 0.0 2.4 2 0 0 2 2 2 2 Dienelactone hydrolase family BAAT_C PF08840.11 EKE40923.1 - 0.0091 15.9 0.0 0.018 15.0 0.0 1.4 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Chlorophyllase2 PF12740.7 EKE40923.1 - 0.024 13.6 0.0 0.036 13.0 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme YARHG PF13308.6 EKE40923.1 - 0.059 13.3 0.7 0.11 12.4 0.1 1.7 2 0 0 2 2 2 0 YARHG domain Abhydrolase_4 PF08386.10 EKE40923.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein DUF900 PF05990.12 EKE40923.1 - 0.17 11.4 0.0 3.8 6.9 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Esterase PF00756.20 EKE40923.1 - 0.18 11.4 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Putative esterase Pyr_redox_2 PF07992.14 EKE40924.1 - 3.4e-11 42.9 0.1 3.4e-11 42.9 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ATP-grasp_5 PF13549.6 EKE40925.1 - 7.2e-79 264.3 0.1 1e-78 263.8 0.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 EKE40925.1 - 4.7e-55 185.2 0.3 2.6e-54 182.8 0.1 2.0 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EKE40925.1 - 2.5e-19 69.9 0.5 2.5e-18 66.7 0.1 2.6 3 0 0 3 3 3 1 CoA binding domain CoA_binding PF02629.19 EKE40925.1 - 7.6e-12 45.8 0.3 7.6e-12 45.8 0.3 2.6 3 0 0 3 3 3 1 CoA binding domain ATP-grasp_2 PF08442.10 EKE40925.1 - 1.4e-05 24.7 0.6 3.1e-05 23.6 0.6 1.6 1 1 0 1 1 1 1 ATP-grasp domain OKR_DC_1_N PF03709.15 EKE40925.1 - 0.061 13.6 0.0 0.36 11.1 0.0 2.1 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain Got1 PF04178.12 EKE40926.1 - 7.6e-06 26.3 22.6 1.2e-05 25.7 21.8 1.6 1 1 0 1 1 1 1 Got1/Sft2-like family PTPS_related PF10131.9 EKE40926.1 - 0.53 8.5 7.8 0.63 8.3 7.8 1.1 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein Alpha-amylase PF00128.24 EKE40927.1 - 1.6e-119 399.4 8.0 2.4e-119 398.9 8.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 EKE40927.1 - 0.00012 22.1 0.0 0.00031 20.8 0.0 1.8 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain 7TMR-DISMED2 PF07696.11 EKE40927.1 - 0.18 11.9 4.1 3.9 7.5 0.1 2.9 3 0 0 3 3 3 0 7TMR-DISM extracellular 2 Enolase_C PF00113.22 EKE40928.1 - 4.6e-136 452.9 0.1 5.8e-136 452.5 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EKE40928.1 - 9.3e-61 203.8 0.0 1.6e-60 203.0 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EKE40928.1 - 1.9e-07 30.9 0.0 3.7e-07 29.9 0.0 1.5 1 1 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EKE40928.1 - 0.0015 17.7 0.2 0.003 16.8 0.2 1.4 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Pkinase_Tyr PF07714.17 EKE40929.1 - 1e-58 198.6 0.0 2.1e-58 197.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40929.1 - 7.4e-56 189.4 0.2 1.7e-55 188.3 0.2 1.5 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EKE40929.1 - 1.1e-21 76.8 2.7 0.00016 22.2 0.0 5.9 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKE40929.1 - 9.2e-18 64.6 20.3 1.1e-08 35.5 0.8 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EKE40929.1 - 4.5e-15 55.3 0.0 0.0035 17.7 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EKE40929.1 - 3.7e-13 49.4 1.4 3.4e-06 27.2 0.0 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE40929.1 - 1.4e-11 43.5 0.4 0.072 13.7 0.0 5.6 5 0 0 5 5 5 3 Ankyrin repeat Pkinase_fungal PF17667.1 EKE40929.1 - 0.0022 16.8 0.0 0.0049 15.7 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase SAM_2 PF07647.17 EKE40929.1 - 0.0022 18.0 0.4 0.0059 16.7 0.4 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kdo PF06293.14 EKE40929.1 - 0.014 14.8 0.1 0.034 13.5 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SAM_1 PF00536.30 EKE40929.1 - 0.019 15.4 0.3 0.068 13.6 0.3 1.9 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) AMP-binding PF00501.28 EKE40930.1 - 2.4e-73 247.2 0.0 3e-73 246.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EKE40930.1 - 0.00041 21.3 0.0 0.0013 19.7 0.0 1.8 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain SH3_1 PF00018.28 EKE40930.1 - 0.018 14.6 0.0 0.057 13.0 0.0 1.9 2 0 0 2 2 2 0 SH3 domain ELK PF03789.13 EKE40930.1 - 0.067 13.3 0.2 0.32 11.1 0.0 2.3 2 0 0 2 2 2 0 ELK domain CDC73_C PF05179.14 EKE40934.1 - 3.1e-11 43.2 0.2 1.1e-10 41.5 0.2 1.9 1 1 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal Lectin_leg-like PF03388.13 EKE40935.1 - 5.2e-38 130.7 0.5 8.5e-38 130.0 0.5 1.3 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.19 EKE40935.1 - 2.3e-09 37.2 0.2 4.4e-09 36.3 0.2 1.4 1 0 0 1 1 1 1 Legume lectin domain DUF5089 PF17002.5 EKE40935.1 - 0.074 12.9 5.4 0.13 12.1 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) DUF4064 PF13273.6 EKE40936.1 - 0.00018 21.7 0.2 0.0005 20.3 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) Orf78 PF06024.12 EKE40936.1 - 0.024 14.9 0.1 0.29 11.5 0.0 2.3 2 0 0 2 2 2 0 Orf78 (ac78) DUF3149 PF11346.8 EKE40936.1 - 9 6.0 9.8 24 4.6 9.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Methyltransf_31 PF13847.6 EKE40937.1 - 4.5e-11 42.8 0.0 5.5e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE40937.1 - 2.5e-10 40.9 0.0 3.8e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EKE40937.1 - 5.7e-08 32.8 0.0 8.4e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKE40937.1 - 3e-07 31.0 0.0 4.9e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EKE40937.1 - 1.2e-06 29.2 0.0 1.9e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKE40937.1 - 2.9e-06 27.2 0.0 5.2e-06 26.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EKE40937.1 - 3.8e-06 26.6 0.0 5.9e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 PrmA PF06325.13 EKE40937.1 - 4e-06 26.5 0.0 5.3e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EKE40937.1 - 1.6e-05 24.5 0.0 2.2e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EKE40937.1 - 0.0018 17.6 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MetW PF07021.12 EKE40937.1 - 0.0062 16.1 0.0 0.0093 15.6 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.17 EKE40937.1 - 0.0082 15.6 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_5 PF01795.19 EKE40937.1 - 0.01 15.3 0.0 0.013 15.0 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family PCMT PF01135.19 EKE40937.1 - 0.022 14.5 0.0 0.044 13.5 0.0 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.15 EKE40937.1 - 0.041 13.7 0.0 0.059 13.2 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase rRNA_methylase PF06962.12 EKE40937.1 - 0.066 13.2 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative rRNA methylase UPF0020 PF01170.18 EKE40937.1 - 0.067 12.9 0.0 0.62 9.7 0.0 2.0 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Met_10 PF02475.16 EKE40937.1 - 0.071 12.9 0.0 0.092 12.5 0.0 1.1 1 0 0 1 1 1 0 Met-10+ like-protein N6_N4_Mtase PF01555.18 EKE40937.1 - 0.097 12.4 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 DNA methylase AdoMet_MTase PF07757.13 EKE40937.1 - 0.12 12.7 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase TrmK PF04816.12 EKE40937.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase TLD PF07534.16 EKE40938.1 - 3.3e-08 33.8 3.0 4.8e-08 33.3 3.0 1.3 1 0 0 1 1 1 1 TLD SNAP PF14938.6 EKE40939.1 - 3.7e-15 56.1 5.5 6.3e-15 55.3 5.5 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NSF PF02071.20 EKE40939.1 - 9.9e-05 22.4 5.9 0.11 13.3 0.6 4.9 5 0 0 5 5 5 2 Aromatic-di-Alanine (AdAR) repeat CoA_transf_3 PF02515.17 EKE40939.1 - 0.022 13.9 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 CoA-transferase family III UPF1_Zn_bind PF09416.10 EKE40939.1 - 0.32 11.0 2.3 7.7 6.5 0.1 3.5 3 1 0 3 3 3 0 RNA helicase (UPF2 interacting domain) Metallophos_2 PF12850.7 EKE40940.1 - 4.6e-12 46.4 2.8 4.7e-11 43.2 2.8 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EKE40940.1 - 6.2e-11 43.2 2.3 9.1e-11 42.6 2.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_3 PF14582.6 EKE40940.1 - 1.1e-08 34.7 0.2 1e-07 31.5 0.2 2.3 1 1 0 1 1 1 1 Metallophosphoesterase, calcineurin superfamily DNA_pol_E_B PF04042.16 EKE40940.1 - 0.0047 16.3 0.0 0.0079 15.6 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Metallophos PF00149.28 EKE40941.1 - 5.1e-31 108.8 0.0 9.8e-31 107.8 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MapZ_EC1 PF18041.1 EKE40941.1 - 0.017 15.4 6.9 0.032 14.5 6.9 1.3 1 0 0 1 1 1 0 MapZ extracellular domain 1 DUF1411 PF07199.11 EKE40941.1 - 0.25 11.0 2.1 0.46 10.1 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) PCI PF01399.27 EKE40942.1 - 2.2e-14 53.8 0.9 2.2e-14 53.8 0.9 2.7 2 1 0 2 2 2 1 PCI domain RPN5_C PF18098.1 EKE40942.1 - 2.9e-08 33.7 0.9 9.4e-08 32.0 0.9 2.0 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain Suppressor_P21 PF11479.8 EKE40942.1 - 0.03 14.5 1.8 0.16 12.2 0.2 2.6 3 0 0 3 3 3 0 RNA silencing suppressor P21 C-terminal domain Beta-Casp PF10996.8 EKE40943.1 - 8.1e-27 93.7 0.0 3.7e-26 91.6 0.0 2.1 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_6 PF16661.5 EKE40943.1 - 3.7e-15 55.9 0.1 3.6e-14 52.6 0.0 2.7 3 2 1 4 4 4 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EKE40943.1 - 3.5e-13 50.0 0.0 6.2e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 EKE40943.1 - 4.7e-13 48.9 0.1 1.4e-12 47.3 0.1 1.9 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 EKE40943.1 - 2.1e-06 27.4 0.5 3e-06 26.9 0.0 1.5 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EKE40943.1 - 0.00023 21.1 0.0 0.00058 19.8 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain CPSF73-100_C PF11718.8 EKE40943.1 - 0.0004 20.0 5.2 0.0015 18.1 5.2 1.9 1 1 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term TPR_2 PF07719.17 EKE40944.1 - 0.0039 17.2 1.3 0.43 10.8 0.4 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat PCI PF01399.27 EKE40944.1 - 0.004 17.6 0.5 0.004 17.6 0.5 2.6 3 1 0 3 3 3 1 PCI domain Met_gamma_lyase PF06838.11 EKE40944.1 - 0.011 14.3 2.2 0.016 13.8 2.2 1.1 1 0 0 1 1 1 0 Methionine gamma-lyase DUF4470 PF14737.6 EKE40944.1 - 0.047 13.9 1.8 0.11 12.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4470) NB PF04159.13 EKE40944.1 - 0.59 10.2 5.2 0.28 11.2 0.2 2.4 2 0 0 2 2 2 0 NB glycoprotein zf-UBR PF02207.20 EKE40946.1 - 3.7 7.8 11.1 11 6.3 11.1 1.8 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) HMG_box_2 PF09011.10 EKE40947.1 - 1.5e-07 31.9 0.9 1.5e-07 31.9 0.9 2.4 2 0 0 2 2 2 1 HMG-box domain HMG_box PF00505.19 EKE40947.1 - 1e-06 29.0 0.6 1e-06 29.0 0.6 2.4 2 2 0 2 2 2 1 HMG (high mobility group) box Pkinase_Tyr PF07714.17 EKE40948.1 - 6.8e-38 130.4 0.0 1.7e-37 129.1 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40948.1 - 3.5e-27 95.4 0.1 1.2e-26 93.7 0.1 1.9 1 0 0 1 1 1 1 Protein kinase domain Myotub-related PF06602.14 EKE40948.1 - 3.2e-16 59.2 2.1 3.2e-16 59.2 2.1 2.0 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain LRR_4 PF12799.7 EKE40948.1 - 7.8e-15 54.8 42.5 0.00021 21.6 3.0 7.7 5 2 1 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE40948.1 - 1.8e-13 50.0 25.0 2.3e-07 30.5 4.0 5.4 3 1 2 6 6 6 5 Leucine rich repeat GRAM PF02893.20 EKE40948.1 - 0.0014 18.5 0.8 0.0096 15.8 0.1 2.8 2 0 0 2 2 2 1 GRAM domain LRR_1 PF00560.33 EKE40948.1 - 0.0042 17.4 29.6 22 6.1 1.1 9.1 9 0 0 9 9 9 2 Leucine Rich Repeat Ist1 PF03398.14 EKE40949.1 - 6.4e-14 52.2 2.0 9.8e-14 51.6 2.0 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway SART-1 PF03343.13 EKE40950.1 - 4.1e-10 38.9 0.0 1.4e-09 37.2 0.0 1.7 1 1 1 2 2 2 1 SART-1 family IL10 PF00726.17 EKE40950.1 - 0.072 12.6 0.1 0.085 12.4 0.1 1.2 1 0 0 1 1 1 0 Interleukin 10 WD40 PF00400.32 EKE40951.1 - 0.00047 20.9 2.0 7.3 7.6 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat PQQ_3 PF13570.6 EKE40951.1 - 0.0011 19.4 0.0 0.31 11.6 0.0 2.7 2 0 0 2 2 2 2 PQQ-like domain eIF2A PF08662.11 EKE40951.1 - 0.039 13.8 0.1 0.098 12.5 0.1 1.7 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A MIG-14_Wnt-bd PF06664.12 EKE40952.1 - 7.4e-20 71.3 14.3 8.8e-20 71.1 14.3 1.0 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion EcsB PF05975.12 EKE40952.1 - 0.0066 15.4 8.9 0.0082 15.0 8.9 1.0 1 0 0 1 1 1 1 Bacterial ABC transporter protein EcsB ECSCR PF15820.5 EKE40952.1 - 0.02 14.7 0.3 0.02 14.7 0.3 2.0 2 1 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator COX4_pro PF03626.14 EKE40952.1 - 0.081 13.4 7.9 0.15 12.5 0.1 2.5 2 1 0 2 2 2 0 Prokaryotic Cytochrome C oxidase subunit IV ER_lumen_recept PF00810.18 EKE40952.1 - 1.3 9.8 12.5 0.18 12.6 5.6 1.9 1 1 1 2 2 2 0 ER lumen protein retaining receptor Ribosomal_S17e PF00833.18 EKE40954.1 - 5.5e-56 187.8 1.1 5.9e-56 187.7 1.1 1.0 1 0 0 1 1 1 1 Ribosomal S17 RRM_1 PF00076.22 EKE40955.1 - 3.3e-21 74.9 2.9 8.3e-16 57.6 0.5 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKE40955.1 - 2.6e-06 27.2 0.4 7.4e-06 25.7 0.0 1.9 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_5 PF13893.6 EKE40955.1 - 6.4e-05 22.5 0.1 0.0037 16.9 0.0 2.3 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE40955.1 - 0.0039 17.2 1.8 0.57 10.2 0.1 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EKE40955.1 - 0.025 14.6 3.6 2.3 8.3 0.1 2.4 2 0 0 2 2 2 0 RNA binding motif Histone PF00125.24 EKE40956.1 - 1.4e-38 132.3 4.4 1.5e-38 132.1 4.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EKE40956.1 - 0.00012 22.4 0.1 0.0003 21.1 0.0 1.6 2 0 0 2 2 2 1 CENP-S protein CENP-T_C PF15511.6 EKE40956.1 - 0.00014 21.9 1.0 0.00037 20.6 0.1 1.9 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EKE40956.1 - 0.086 13.1 1.9 0.093 13.0 0.1 1.8 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EKE40956.1 - 0.098 12.7 0.4 0.68 10.0 0.0 1.9 1 1 1 2 2 2 0 Transcription initiation factor IID, 31kD subunit zf-ANAPC11 PF12861.7 EKE40958.1 - 9.9e-25 86.4 16.2 1.1e-24 86.3 16.2 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EKE40958.1 - 5.5e-18 65.0 21.7 7.6e-18 64.6 21.7 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EKE40958.1 - 4e-09 36.7 16.7 4e-09 36.7 16.7 2.2 1 1 1 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKE40958.1 - 0.00069 19.4 22.3 0.00069 19.4 22.3 2.4 1 1 1 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE40958.1 - 0.002 18.1 19.1 0.044 13.8 18.4 2.5 1 1 1 2 2 2 2 RING-type zinc-finger U-box PF04564.15 EKE40958.1 - 0.01 16.0 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 U-box domain zf-RING_5 PF14634.6 EKE40958.1 - 0.02 14.8 20.0 0.02 14.8 20.0 2.6 1 1 2 3 3 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EKE40958.1 - 0.19 11.6 25.7 6 6.8 25.7 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE40958.1 - 0.32 10.9 28.5 3.7 7.5 28.5 2.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE40958.1 - 0.62 10.0 24.7 0.29 11.0 16.9 2.4 1 1 1 2 2 1 0 Prokaryotic RING finger family 4 Rtf2 PF04641.12 EKE40958.1 - 3.5 6.9 8.1 3.8 6.8 8.1 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Rad50_zn_hook PF04423.14 EKE40958.1 - 4.1 7.3 0.0 4.1 7.3 0.0 3.0 2 1 1 3 3 2 0 Rad50 zinc hook motif Zn_ribbon_17 PF17120.5 EKE40958.1 - 4.7 6.9 24.1 66 3.2 24.1 2.3 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Steroid_dh PF02544.16 EKE40959.1 - 1.3e-08 34.9 6.2 2.6e-08 34.0 6.2 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.23 EKE40959.1 - 1.8e-07 30.8 0.1 2.7e-07 30.2 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKE40959.1 - 0.029 14.2 0.3 0.047 13.5 0.3 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF4519 PF15012.6 EKE40959.1 - 0.79 9.9 2.3 9.9 6.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) PNTB_4TM PF12769.7 EKE40959.1 - 2.5 8.6 5.6 1 9.9 0.4 2.7 3 0 0 3 3 3 0 4TM region of pyridine nucleotide transhydrogenase, mitoch DENN PF02141.21 EKE40960.1 - 6.4e-20 71.9 1.0 2.1e-19 70.2 1.0 2.0 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 EKE40960.1 - 0.00039 20.3 7.8 0.0015 18.5 7.8 2.0 1 0 0 1 1 1 1 dDENN domain LIM PF00412.22 EKE40960.1 - 0.037 14.2 4.8 0.12 12.7 4.8 2.0 1 0 0 1 1 1 0 LIM domain DUF3267 PF11667.8 EKE40960.1 - 0.24 11.7 1.6 0.51 10.7 1.6 1.5 1 0 0 1 1 1 0 Putative zincin peptidase DUF2605 PF10792.9 EKE40960.1 - 0.79 9.7 3.1 3.6 7.6 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) Peptidase_M20 PF01546.28 EKE40961.1 - 1.2e-17 64.3 1.2 4.1e-17 62.6 1.2 1.9 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 EKE40961.1 - 0.00036 20.3 0.0 0.00061 19.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 M20_dimer PF07687.14 EKE40961.1 - 0.0019 18.1 2.2 0.0023 17.8 1.2 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M42 PF05343.14 EKE40961.1 - 0.01 14.9 2.0 3.5 6.6 0.0 3.7 3 1 1 4 4 4 0 M42 glutamyl aminopeptidase TruD PF01142.18 EKE40961.1 - 0.094 11.5 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) tRNA_int_endo PF01974.17 EKE40962.1 - 4.9e-19 68.2 0.0 7.2e-19 67.6 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Terminase_3 PF04466.13 EKE40962.1 - 0.0033 17.0 0.2 0.0053 16.3 0.2 1.3 1 0 0 1 1 1 1 Phage terminase large subunit CPSase_L_D3 PF02787.19 EKE40962.1 - 0.071 13.5 0.3 0.11 12.8 0.3 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain RasGAP PF00616.19 EKE40963.1 - 2e-14 53.8 5.6 2.1e-06 27.6 1.2 3.2 3 0 0 3 3 3 2 GTPase-activator protein for Ras-like GTPase Cbl_N PF02262.16 EKE40963.1 - 0.015 15.3 1.1 0.066 13.2 0.2 2.4 1 1 2 3 3 3 0 CBL proto-oncogene N-terminal domain 1 bZIP_1 PF00170.21 EKE40963.1 - 0.048 13.8 0.5 0.15 12.2 0.1 2.1 2 0 0 2 2 2 0 bZIP transcription factor ANF_receptor PF01094.28 EKE40965.1 - 0.00064 18.9 0.0 0.00072 18.8 0.0 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 EKE40965.1 - 0.015 14.9 0.0 0.018 14.7 0.0 1.1 1 0 0 1 1 1 0 Periplasmic binding protein DUF1981 PF09324.10 EKE40966.1 - 0.043 13.7 0.4 0.55 10.1 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) DUF5319 PF17252.2 EKE40966.1 - 0.38 11.0 1.4 1.1 9.5 1.4 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5319) IFT46_B_C PF12317.8 EKE40966.1 - 1.1 8.9 10.6 4 7.1 0.3 3.1 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal zf-C4H2 PF10146.9 EKE40966.1 - 7.2 6.9 26.0 0.06 13.7 16.1 2.6 2 0 0 2 2 2 0 Zinc finger-containing protein Ras PF00071.22 EKE40967.1 - 4.9e-17 62.0 0.1 6.4e-17 61.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40967.1 - 0.0028 17.9 0.0 0.0044 17.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FH2 PF02181.23 EKE40969.1 - 6.7e-20 71.5 6.0 6.7e-20 71.5 6.0 2.7 2 1 0 2 2 2 1 Formin Homology 2 Domain APG6_N PF17675.1 EKE40969.1 - 0.32 11.5 12.4 0.2 12.2 7.9 2.8 2 0 0 2 2 2 0 Apg6 coiled-coil region Spectrin PF00435.21 EKE40969.1 - 2.5 8.7 10.0 9.5 6.8 7.5 2.7 2 0 0 2 2 2 0 Spectrin repeat Coatomer_WDAD PF04053.14 EKE40970.1 - 6.9e-139 463.7 3.1 6.9e-139 463.7 3.1 2.3 3 0 0 3 3 3 1 Coatomer WD associated region WD40 PF00400.32 EKE40970.1 - 1.3e-34 117.6 9.6 1.9e-05 25.3 0.0 9.1 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE40970.1 - 6.8e-07 29.5 0.8 1.2 9.4 0.0 6.3 4 3 4 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EKE40970.1 - 7e-06 26.0 0.8 1.2 9.2 0.0 4.8 3 2 0 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.11 EKE40970.1 - 0.00014 20.7 0.4 0.0016 17.2 0.1 2.5 1 1 0 3 3 3 1 Nup133 N terminal like Clathrin PF00637.20 EKE40970.1 - 0.012 15.4 4.3 0.15 11.9 0.3 2.6 1 1 2 3 3 3 0 Region in Clathrin and VPS Nup160 PF11715.8 EKE40970.1 - 0.033 12.8 0.3 2.9 6.4 0.0 3.0 1 1 2 3 3 3 0 Nucleoporin Nup120/160 DUF421 PF04239.12 EKE40970.1 - 0.16 11.8 0.2 1 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF421) Metallophos PF00149.28 EKE40972.1 - 4.8e-26 92.5 0.8 5.9e-26 92.2 0.8 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE40972.1 - 0.032 14.4 0.0 0.044 14.0 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Rhodanese PF00581.20 EKE40973.1 - 9.3e-10 39.0 0.0 2.5e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain RabGAP-TBC PF00566.18 EKE40973.1 - 9.9e-05 22.1 4.7 0.00034 20.3 4.6 1.9 1 1 0 2 2 2 1 Rab-GTPase-TBC domain DUF2408 PF10303.9 EKE40973.1 - 0.15 12.7 1.1 38 4.8 0.0 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF2408) AAA_lid_9 PF17871.1 EKE40973.1 - 1 9.3 4.0 0.93 9.5 1.5 2.1 2 0 0 2 2 2 0 AAA lid domain FlaC_arch PF05377.11 EKE40974.1 - 0.0023 18.3 5.2 0.28 11.6 0.0 4.4 3 0 0 3 3 3 2 Flagella accessory protein C (FlaC) 60KD_IMP PF02096.20 EKE40974.1 - 0.15 11.9 0.1 0.15 11.9 0.1 3.4 2 1 1 4 4 4 0 60Kd inner membrane protein AAA PF00004.29 EKE40975.1 - 2.1e-44 151.1 0.0 5e-44 149.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EKE40975.1 - 3.9e-12 45.9 0.5 2.7e-11 43.2 0.1 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EKE40975.1 - 2.7e-09 36.7 0.0 7.2e-09 35.3 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EKE40975.1 - 3.7e-08 33.5 0.1 1.4e-07 31.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EKE40975.1 - 3.8e-08 33.6 0.0 1.1e-07 32.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EKE40975.1 - 2.3e-06 28.1 0.4 0.00019 21.8 0.0 2.5 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EKE40975.1 - 3.2e-05 24.2 1.9 0.0066 16.7 0.9 3.0 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EKE40975.1 - 0.00014 22.4 0.0 0.00064 20.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EKE40975.1 - 0.00041 20.1 0.0 0.0013 18.5 0.0 1.9 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EKE40975.1 - 0.0006 19.1 0.0 0.0011 18.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 EKE40975.1 - 0.00084 19.6 0.0 0.0022 18.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EKE40975.1 - 0.0017 18.1 0.0 0.005 16.6 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EKE40975.1 - 0.0024 17.1 0.0 0.0042 16.3 0.0 1.4 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_30 PF13604.6 EKE40975.1 - 0.0025 17.6 0.0 0.0057 16.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EKE40975.1 - 0.0031 16.9 0.0 0.0071 15.8 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EKE40975.1 - 0.0035 17.3 0.1 0.098 12.6 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_14 PF13173.6 EKE40975.1 - 0.0036 17.3 0.0 0.0098 15.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EKE40975.1 - 0.0038 16.8 1.4 0.027 14.1 0.1 2.2 1 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EKE40975.1 - 0.0062 16.9 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_24 PF13479.6 EKE40975.1 - 0.0084 15.9 0.1 0.019 14.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EKE40975.1 - 0.0095 15.9 0.0 0.19 11.7 0.0 2.5 2 0 0 2 2 2 1 NTPase TniB PF05621.11 EKE40975.1 - 0.012 15.0 0.0 0.87 9.0 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein Sigma54_activat PF00158.26 EKE40975.1 - 0.015 15.0 0.0 0.25 11.0 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 EKE40975.1 - 0.022 14.3 0.0 0.077 12.5 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 EKE40975.1 - 0.024 14.6 0.0 0.068 13.2 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EKE40975.1 - 0.034 14.7 0.4 1 9.9 0.0 2.9 2 1 0 2 2 2 0 ABC transporter DegS PF05384.11 EKE40975.1 - 0.034 13.6 0.6 0.075 12.5 0.6 1.6 1 0 0 1 1 1 0 Sensor protein DegS AAA_33 PF13671.6 EKE40975.1 - 0.036 14.2 0.2 0.13 12.5 0.2 2.0 1 1 1 2 2 2 0 AAA domain AAA_3 PF07726.11 EKE40975.1 - 0.04 13.8 0.0 0.17 11.8 0.0 2.1 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 EKE40975.1 - 0.054 12.6 0.0 0.095 11.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 EKE40975.1 - 0.08 12.7 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Prot_ATP_OB_N PF17758.1 EKE40975.1 - 0.097 12.3 0.1 0.45 10.2 0.0 2.0 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain ATPase PF06745.13 EKE40975.1 - 0.11 11.8 1.8 1.2 8.5 0.0 2.5 2 1 1 3 3 3 0 KaiC AAA_21 PF13304.6 EKE40975.1 - 0.13 12.0 0.2 23 4.7 0.0 3.1 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system WH2 PF02205.20 EKE40976.1 - 3.9e-09 36.0 1.8 3.9e-09 36.0 1.8 1.9 2 0 0 2 2 1 1 WH2 motif DUF1664 PF07889.12 EKE40976.1 - 0.00022 21.3 16.4 0.057 13.5 8.2 2.2 1 1 0 2 2 2 2 Protein of unknown function (DUF1664) DUF4201 PF13870.6 EKE40976.1 - 0.0028 17.4 1.7 0.0028 17.4 1.7 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) CK2S PF15011.6 EKE40976.1 - 0.008 16.1 1.3 0.022 14.6 1.3 1.8 1 1 0 1 1 1 1 Casein Kinase 2 substrate Laminin_II PF06009.12 EKE40976.1 - 0.013 15.5 1.9 0.013 15.5 1.9 2.5 2 0 0 2 2 2 0 Laminin Domain II Spc7 PF08317.11 EKE40976.1 - 0.042 12.7 14.0 0.073 11.9 14.0 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.6 EKE40976.1 - 0.12 12.8 11.5 0.73 10.3 0.5 2.5 2 0 0 2 2 2 0 Snapin/Pallidin EzrA PF06160.12 EKE40976.1 - 0.14 10.3 17.6 0.39 8.8 1.8 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF2203 PF09969.9 EKE40976.1 - 0.15 12.8 5.7 0.85 10.3 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) APG17 PF04108.12 EKE40976.1 - 0.16 11.1 13.0 0.18 10.9 0.6 2.2 1 1 1 2 2 2 0 Autophagy protein Apg17 HAUS-augmin3 PF14932.6 EKE40976.1 - 0.19 11.3 8.2 0.17 11.5 5.7 1.8 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 ApoO PF09769.9 EKE40976.1 - 0.36 10.8 3.7 14 5.7 0.1 2.7 1 1 1 2 2 2 0 Apolipoprotein O DUF4446 PF14584.6 EKE40976.1 - 0.5 10.3 13.4 2.9 7.8 5.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF948 PF06103.11 EKE40976.1 - 0.52 10.6 9.8 1.4 9.2 1.0 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TPR_MLP1_2 PF07926.12 EKE40976.1 - 0.64 10.1 10.8 1.1 9.4 1.0 2.3 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein KxDL PF10241.9 EKE40976.1 - 0.73 10.2 9.1 0.38 11.0 0.5 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein BLOC1_2 PF10046.9 EKE40976.1 - 0.73 10.2 11.6 3.2 8.1 7.8 2.7 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Glyco_hydro_67N PF03648.14 EKE40976.1 - 0.93 9.8 4.0 11 6.3 1.3 2.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 67 N-terminus MCPsignal PF00015.21 EKE40976.1 - 0.99 9.2 13.8 1 9.1 10.0 2.3 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1643 PF07799.12 EKE40976.1 - 1.4 9.1 6.2 2.4 8.3 0.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1643) DUF745 PF05335.13 EKE40976.1 - 1.7 8.3 11.4 1.4 8.6 0.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF745) FliD_N PF02465.18 EKE40976.1 - 3 8.6 8.9 10 6.9 1.5 2.7 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF16 PF01519.16 EKE40976.1 - 3.8 8.1 16.8 1.7 9.2 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF16 GldM_N PF12081.8 EKE40976.1 - 3.8 7.5 14.7 0.17 12.0 1.9 2.7 1 1 2 3 3 3 0 GldM N-terminal domain LMBR1 PF04791.16 EKE40976.1 - 5 5.9 9.5 6.5 5.5 9.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 EKE40976.1 - 5.4 6.2 15.3 3.4 6.8 8.3 2.2 1 1 1 2 2 2 0 TMPIT-like protein eIF3_N PF09440.10 EKE40976.1 - 6.5 7.2 12.7 12 6.4 5.5 2.4 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain CAP_N PF01213.19 EKE40976.1 - 7.7 5.9 17.7 1.6e+02 1.6 17.3 2.5 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal RecG_N PF17190.4 EKE40976.1 - 8 7.3 11.7 20 6.0 1.1 2.5 2 0 0 2 2 2 0 RecG N-terminal helical domain Fib_alpha PF08702.10 EKE40976.1 - 8.6 6.5 20.9 7.3 6.8 3.6 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Pkinase_Tyr PF07714.17 EKE40977.1 - 1.5e-18 67.1 0.0 2.7e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40977.1 - 6.9e-18 65.0 0.0 2.7e-17 63.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Orf78 PF06024.12 EKE40977.1 - 0.067 13.5 0.5 0.28 11.5 0.2 2.2 2 0 0 2 2 2 0 Orf78 (ac78) TMIE PF16038.5 EKE40977.1 - 0.32 10.9 2.2 1.1 9.1 2.2 1.9 1 0 0 1 1 1 0 TMIE protein Orthoreo_P10 PF07204.11 EKE40977.1 - 2 8.4 6.1 0.2 11.6 1.2 1.9 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 FNIP PF05725.12 EKE40978.1 - 0.18 12.0 25.3 3.4 7.9 4.4 6.2 3 1 2 5 5 5 0 FNIP Repeat Seryl_tRNA_N PF02403.22 EKE40979.1 - 0.022 15.0 19.7 0.022 15.0 19.7 3.7 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain HALZ PF02183.18 EKE40979.1 - 0.023 14.9 4.5 0.023 14.9 4.5 5.7 7 0 0 7 7 7 0 Homeobox associated leucine zipper ERM PF00769.19 EKE40979.1 - 0.13 12.1 52.0 0.13 12.0 33.1 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family AAA_13 PF13166.6 EKE40979.1 - 0.33 9.5 41.1 0.031 13.0 24.8 2.0 1 1 1 2 2 2 0 AAA domain DUF3584 PF12128.8 EKE40979.1 - 0.37 8.3 40.3 0.53 7.7 40.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Jnk-SapK_ap_N PF09744.9 EKE40979.1 - 0.38 11.0 50.1 0.48 10.6 27.9 3.1 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Golgin_A5 PF09787.9 EKE40979.1 - 0.38 10.2 50.0 1.6 8.2 32.2 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 Spc7 PF08317.11 EKE40979.1 - 0.77 8.6 51.9 1.3 7.8 13.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein MAD PF05557.13 EKE40979.1 - 0.88 7.9 52.2 0.21 9.9 36.0 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF1192 PF06698.11 EKE40979.1 - 1.2 9.3 17.6 1.4 9.0 2.3 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) ADIP PF11559.8 EKE40979.1 - 1.5 8.9 51.4 3.9 7.5 28.7 2.8 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.12 EKE40979.1 - 2.5 8.2 51.6 0.53 10.4 26.1 2.9 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein UPF0449 PF15136.6 EKE40979.1 - 3 8.4 37.0 0.98 9.9 8.9 4.2 2 1 2 4 4 4 0 Uncharacterised protein family UPF0449 AIP3 PF03915.13 EKE40979.1 - 5.4 6.0 39.3 2.6 7.0 19.6 2.1 1 1 1 2 2 2 0 Actin interacting protein 3 HAUS-augmin3 PF14932.6 EKE40979.1 - 5.9 6.4 40.9 0.94 9.0 30.1 2.2 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 HD_2 PF12917.7 EKE40979.1 - 6.9 6.4 23.7 0.077 12.7 13.6 2.4 1 1 1 2 2 2 0 HD containing hydrolase-like enzyme zf-C4H2 PF10146.9 EKE40979.1 - 8 6.7 40.1 0.11 12.8 22.8 2.2 1 1 1 2 2 2 0 Zinc finger-containing protein HRDC PF00570.23 EKE40980.1 - 0.002 18.1 0.0 0.004 17.1 0.0 1.6 1 0 0 1 1 1 1 HRDC domain U3_assoc_6 PF08640.11 EKE40980.1 - 0.48 10.5 6.3 1.6 8.9 0.1 3.5 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 6 tRNA-synt_1c PF00749.21 EKE40981.1 - 6.8e-93 311.0 0.0 9.5e-93 310.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EKE40981.1 - 3.8e-39 134.3 0.1 8e-39 133.3 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain FeoB_associated PF12669.7 EKE40982.1 - 2.6 8.5 4.7 5.3 7.5 4.7 1.5 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Sigma70_ner PF04546.13 EKE40983.1 - 3.8 7.3 12.1 4.8 7.0 12.1 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region DNA_pol_phi PF04931.13 EKE40983.1 - 9.3 4.2 20.5 11 4.0 20.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi Ras PF00071.22 EKE40984.1 - 1e-42 145.5 0.3 1.2e-42 145.3 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE40984.1 - 7.9e-27 93.9 0.0 1e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE40984.1 - 2.7e-09 36.7 0.0 3e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE40984.1 - 3.8e-06 26.4 0.0 4.3e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE40984.1 - 7.1e-05 22.9 0.0 9.1e-05 22.5 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EKE40984.1 - 0.0085 16.4 0.6 0.21 11.9 0.6 2.2 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EKE40984.1 - 0.0099 15.3 0.0 0.011 15.1 0.0 1.2 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Fe-S_assembly PF04384.13 EKE40985.1 - 0.0079 16.8 0.1 0.12 13.0 0.1 2.8 2 0 0 2 2 2 1 Iron-sulphur cluster assembly DUF5446 PF17522.2 EKE40985.1 - 0.02 15.0 3.0 0.02 15.0 3.0 2.6 2 1 0 3 3 3 0 Family of unknown function (DUF5446) DUF812 PF05667.11 EKE40985.1 - 0.032 13.1 7.0 0.043 12.7 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF948 PF06103.11 EKE40985.1 - 0.065 13.5 8.0 1.6 9.1 2.4 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HSBP1 PF06825.12 EKE40985.1 - 0.14 12.1 1.2 0.61 10.0 0.3 2.6 2 0 0 2 2 2 0 Heat shock factor binding protein 1 LMBR1 PF04791.16 EKE40985.1 - 0.14 11.0 5.6 0.19 10.6 5.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DivIC PF04977.15 EKE40985.1 - 0.18 11.6 0.3 0.18 11.6 0.3 2.4 2 1 1 3 3 3 0 Septum formation initiator DUF1664 PF07889.12 EKE40985.1 - 2.2 8.3 10.6 6.3 6.9 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EKE40985.1 - 4.7 7.2 8.9 4.1 7.4 3.3 2.2 1 1 1 2 2 2 0 Laminin Domain II XhlA PF10779.9 EKE40985.1 - 7.2 6.9 8.2 2.3 8.5 1.0 2.7 2 1 1 3 3 3 0 Haemolysin XhlA Osmo_CC PF08946.10 EKE40985.1 - 8 6.8 7.0 74 3.7 4.0 3.3 2 1 0 2 2 2 0 Osmosensory transporter coiled coil DUF4215 PF13948.6 EKE40987.1 - 0.00044 20.6 19.8 0.00044 20.6 19.8 4.1 2 2 1 3 3 3 1 Domain of unknown function (DUF4215) Tox-HNH-HHH PF15637.6 EKE40987.1 - 0.14 12.3 0.1 12 6.2 0.0 2.5 2 0 0 2 2 2 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif TIG PF01833.24 EKE40988.1 - 1.6e-05 24.9 5.2 0.0019 18.2 0.0 2.6 2 0 0 2 2 2 2 IPT/TIG domain Siva PF05458.12 EKE40988.1 - 0.0078 15.9 3.0 0.0078 15.9 3.0 1.6 2 0 0 2 2 2 1 Cd27 binding protein (Siva) FYVE PF01363.21 EKE40988.1 - 0.032 14.4 8.7 0.093 12.9 8.7 1.7 1 0 0 1 1 1 0 FYVE zinc finger RVT_3 PF13456.6 EKE40989.1 - 0.048 13.5 1.1 6 6.7 0.2 2.7 2 0 0 2 2 2 0 Reverse transcriptase-like Prismane PF03063.20 EKE40989.1 - 2.5 6.7 10.5 0.15 10.8 3.6 1.8 1 1 1 2 2 2 0 Prismane/CO dehydrogenase family BPL_N PF09825.9 EKE40989.1 - 3 6.8 13.3 4.1 6.4 13.3 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Pkinase_Tyr PF07714.17 EKE40990.1 - 9.2e-33 113.6 0.0 1.7e-32 112.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE40990.1 - 6.3e-25 88.0 0.3 1.2e-24 87.2 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain VSP PF03302.13 EKE40990.1 - 0.001 18.0 35.6 0.001 18.0 35.6 5.4 1 1 3 4 4 4 2 Giardia variant-specific surface protein Insulin_TMD PF17870.1 EKE40990.1 - 0.035 14.2 2.8 0.081 13.0 2.8 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment CwfJ_C_1 PF04677.15 EKE40992.1 - 5.7e-22 77.9 2.4 8.9e-22 77.2 0.9 2.1 1 1 1 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EKE40992.1 - 8.2e-06 26.6 0.1 4.5e-05 24.3 0.0 2.2 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 SMI1_KNR4 PF09346.10 EKE40992.1 - 0.028 14.8 2.3 0.17 12.3 0.1 2.8 2 0 0 2 2 2 0 SMI1 / KNR4 family (SUKH-1) Nrf1_DNA-bind PF10491.9 EKE40992.1 - 0.21 11.3 2.8 0.53 9.9 2.8 1.7 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Flavodoxin_2 PF02525.17 EKE40993.1 - 4.5e-19 68.9 0.0 5.7e-19 68.6 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EKE40993.1 - 6.2e-18 65.0 0.0 7.7e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Toxin_35 PF10530.9 EKE40994.1 - 0.035 14.1 3.9 0.11 12.4 3.9 1.8 1 0 0 1 1 1 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold DUF3689 PF12463.8 EKE40995.1 - 6.2e-07 29.0 4.6 6.2e-07 29.0 4.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3689) MA3 PF02847.17 EKE40995.1 - 0.022 14.8 2.5 0.18 11.8 0.0 3.1 3 0 0 3 3 3 0 MA3 domain MIG-14_Wnt-bd PF06664.12 EKE40996.1 - 4.8e-60 203.3 51.5 4.8e-60 203.3 51.5 1.7 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion DUF3103 PF11301.8 EKE40996.1 - 0.12 11.2 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3103) UL45 PF05473.12 EKE40996.1 - 2.2 7.9 6.6 2.2 7.9 0.3 2.6 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like SH3_2 PF07653.17 EKE40997.1 - 3.5e-11 42.6 0.0 5.5e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EKE40997.1 - 3.7e-11 42.7 1.2 5.7e-11 42.1 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EKE40997.1 - 6.4e-10 38.5 0.1 1.5e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 SH3 domain BAR PF03114.18 EKE40997.1 - 5.1e-09 36.1 7.2 7.2e-09 35.6 7.2 1.2 1 0 0 1 1 1 1 BAR domain MIP-T3_C PF17749.1 EKE40997.1 - 0.0044 17.0 2.8 0.23 11.4 1.5 2.3 2 0 0 2 2 2 2 Microtubule-binding protein MIP-T3 C-terminal region TPR_2 PF07719.17 EKE40998.1 - 2.8e-35 117.6 21.4 3.2e-06 26.8 0.1 14.7 15 0 0 15 15 14 5 Tetratricopeptide repeat TPR_1 PF00515.28 EKE40998.1 - 1.7e-29 100.4 30.4 9.3e-07 28.4 0.1 13.4 14 0 0 14 14 14 7 Tetratricopeptide repeat TPR_19 PF14559.6 EKE40998.1 - 5.2e-26 90.9 10.6 4.8e-06 27.0 0.1 10.0 9 2 1 11 11 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 EKE40998.1 - 2.9e-22 78.8 13.1 7.4e-07 29.4 0.2 9.4 8 3 1 10 10 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 EKE40998.1 - 1.1e-15 57.0 0.1 1.6 9.7 0.0 9.9 6 2 4 10 10 10 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKE40998.1 - 8.4e-15 53.7 28.4 0.0053 16.9 0.1 12.8 14 1 0 14 14 13 3 Tetratricopeptide repeat TPR_6 PF13174.6 EKE40998.1 - 4.6e-14 52.0 8.5 0.41 11.4 0.0 10.8 13 0 0 13 13 10 3 Tetratricopeptide repeat TPR_17 PF13431.6 EKE40998.1 - 7.5e-13 47.9 17.7 0.23 11.9 0.1 11.8 13 0 0 13 13 12 2 Tetratricopeptide repeat TPR_16 PF13432.6 EKE40998.1 - 8e-13 48.8 0.0 0.0037 17.9 0.0 6.0 5 2 3 8 8 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE40998.1 - 3.3e-12 46.4 28.9 9.7e-06 25.7 0.2 7.5 7 1 1 8 8 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EKE40998.1 - 5.5e-12 45.2 10.3 0.0053 16.4 0.1 8.4 8 1 1 9 9 9 4 TPR repeat TPR_10 PF13374.6 EKE40998.1 - 4.9e-07 29.4 0.9 1.4 8.9 0.2 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 EKE40998.1 - 7.9e-07 28.7 6.0 2.4 8.4 0.0 8.3 11 0 0 11 11 8 2 Tetratricopeptide repeat Coatomer_E PF04733.14 EKE40998.1 - 9.4e-06 25.2 11.4 0.00093 18.7 1.6 5.0 4 2 0 4 4 4 2 Coatomer epsilon subunit DUF3808 PF10300.9 EKE40998.1 - 7.8e-05 21.6 7.1 7.8e-05 21.6 7.1 4.4 3 2 2 5 5 4 2 Protein of unknown function (DUF3808) BTAD PF03704.17 EKE40998.1 - 0.0014 19.1 0.5 0.13 12.7 0.6 3.0 3 0 0 3 3 2 1 Bacterial transcriptional activator domain PPR_1 PF12854.7 EKE40998.1 - 0.015 15.0 0.0 0.058 13.1 0.0 2.1 1 0 0 1 1 1 0 PPR repeat PPR PF01535.20 EKE40998.1 - 0.056 13.7 2.5 4 7.9 0.0 4.9 5 0 0 5 5 4 0 PPR repeat HrpB1_HrpK PF09613.10 EKE40998.1 - 0.068 12.8 0.3 0.62 9.7 0.0 2.8 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_9 PF13371.6 EKE40998.1 - 0.11 12.6 0.1 15 5.8 0.0 3.8 5 0 0 5 5 4 0 Tetratricopeptide repeat Dus PF01207.17 EKE40999.1 - 6.3e-36 124.0 0.0 8.8e-36 123.6 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Nsp1 PF11501.8 EKE40999.1 - 0.0051 16.8 0.1 1.5 8.9 0.0 2.9 4 0 0 4 4 4 2 Non structural protein Nsp1 CENP-T_C PF15511.6 EKE41000.1 - 4.1e-10 39.7 0.2 5.4e-10 39.4 0.2 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 EKE41000.1 - 2.2e-06 27.7 0.1 3.4e-06 27.1 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EKE41000.1 - 2.6e-05 24.6 1.3 5e-05 23.7 1.3 1.5 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EKE41000.1 - 6.2e-05 23.2 0.0 9e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EKE41000.1 - 0.00046 20.5 0.2 0.00064 20.1 0.2 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EKE41000.1 - 0.00054 20.0 0.0 0.00073 19.6 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EKE41000.1 - 0.012 15.6 0.0 0.017 15.2 0.0 1.3 1 1 0 1 1 1 0 Bromodomain associated Vps26 PF03643.15 EKE41001.1 - 6.5e-92 307.4 6.5 7.6e-92 307.2 6.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EKE41001.1 - 7e-06 26.2 1.1 0.0033 17.5 0.5 2.7 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EKE41001.1 - 0.00012 22.5 2.0 0.0014 19.1 1.4 2.7 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Synaptobrevin PF00957.21 EKE41002.1 - 8.1e-05 22.3 0.7 8.1e-05 22.3 0.7 1.1 1 0 0 1 1 1 1 Synaptobrevin Orf78 PF06024.12 EKE41002.1 - 0.05 13.9 0.1 0.053 13.8 0.1 1.0 1 0 0 1 1 1 0 Orf78 (ac78) Sad1_UNC PF07738.13 EKE41003.1 - 1.6e-07 31.4 2.6 3.3e-07 30.4 0.2 2.3 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal F5_F8_type_C PF00754.25 EKE41003.1 - 3.6e-05 23.9 0.3 0.0031 17.6 0.0 3.0 2 1 1 3 3 3 1 F5/8 type C domain DUF1765 PF08578.10 EKE41004.1 - 1e-10 42.1 9.4 2.2e-10 41.1 9.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) RasGAP PF00616.19 EKE41005.1 - 5.8e-24 85.0 9.9 7.1e-19 68.3 4.3 2.7 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase LRR_6 PF13516.6 EKE41005.1 - 1.3e-07 31.0 4.4 2 8.7 0.0 6.7 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 EKE41005.1 - 2.6e-05 24.5 6.5 5.9 7.5 0.0 6.7 4 2 2 6 6 6 2 Leucine Rich repeats (2 copies) DUF3627 PF12299.8 EKE41005.1 - 0.058 13.5 0.7 0.31 11.2 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3627) DSBA PF01323.20 EKE41006.1 - 9.2e-19 68.0 0.0 3.5e-18 66.1 0.0 1.7 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 EKE41006.1 - 7.8e-06 26.1 0.0 0.13 12.4 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EKE41006.1 - 0.0065 16.9 0.0 0.12 12.8 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Microtub_bd PF16796.5 EKE41006.1 - 0.012 15.5 0.5 0.061 13.3 0.0 2.3 2 1 0 2 2 2 0 Microtubule binding Thioredoxin_5 PF13743.6 EKE41006.1 - 0.059 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin tRNA_synthFbeta PF17759.1 EKE41007.1 - 6.8e-36 123.7 0.0 9.9e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EKE41007.1 - 2.2e-30 104.7 5.2 3.1e-27 94.6 0.6 3.2 4 0 0 4 4 4 2 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EKE41007.1 - 4.9e-20 71.9 0.0 7.9e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EKE41007.1 - 1.4e-15 57.3 0.0 2e-12 47.2 0.0 2.7 2 0 0 2 2 2 2 tRNA synthetase B5 domain Pkinase PF00069.25 EKE41008.1 - 3.8e-54 183.8 0.1 3.8e-54 183.8 0.1 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41008.1 - 2e-23 83.0 0.1 1.2e-20 73.9 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Choline_kinase PF01633.20 EKE41008.1 - 0.007 16.0 0.1 0.007 16.0 0.1 2.2 2 0 0 2 2 2 1 Choline/ethanolamine kinase PHM7_cyt PF14703.6 EKE41008.1 - 0.019 15.2 6.0 0.039 14.2 6.0 1.5 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter APH PF01636.23 EKE41008.1 - 0.023 14.7 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family MRP-S26 PF14943.6 EKE41008.1 - 0.046 13.6 14.0 1.1 9.1 13.6 2.5 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 AAA_11 PF13086.6 EKE41008.1 - 0.6 9.8 8.4 1 9.1 8.4 1.3 1 0 0 1 1 1 0 AAA domain Rota_VP2 PF05087.12 EKE41008.1 - 4.5 5.3 8.3 7.3 4.6 8.3 1.2 1 0 0 1 1 1 0 Rotavirus VP2 protein Presenilin PF01080.17 EKE41008.1 - 9.8 4.8 6.7 15 4.2 6.7 1.2 1 0 0 1 1 1 0 Presenilin Vps52 PF04129.12 EKE41009.1 - 1.4e-14 53.7 37.4 2.3e-14 53.0 37.4 1.3 1 0 0 1 1 1 1 Vps52 / Sac2 family 3H PF02829.14 EKE41009.1 - 0.017 15.4 4.7 0.77 10.1 0.4 3.5 3 0 0 3 3 3 0 3H domain Elf4 PF07011.11 EKE41009.1 - 0.044 13.7 3.6 0.096 12.6 0.5 3.1 3 0 0 3 3 3 0 Early Flowering 4 domain RNase_J_C PF17770.1 EKE41009.1 - 0.11 13.5 4.6 3.7 8.7 0.1 4.0 4 0 0 4 4 4 0 Ribonuclease J C-terminal domain DUF1465 PF07323.12 EKE41009.1 - 0.27 11.1 1.0 0.41 10.5 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) Ras PF00071.22 EKE41010.1 - 5.3e-09 35.9 0.2 0.00012 21.7 0.0 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EKE41010.1 - 0.0011 19.2 0.0 1.8 8.8 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase WD40 PF00400.32 EKE41011.1 - 2.1e-24 85.3 10.9 0.011 16.6 0.0 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE41011.1 - 8.4e-18 64.5 0.8 0.014 15.7 0.0 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EKE41011.1 - 1.7e-07 30.3 0.0 0.67 8.5 0.0 4.3 2 1 2 4 4 4 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EKE41011.1 - 0.0022 17.0 1.0 1 8.2 0.1 3.5 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EKE41011.1 - 0.0042 16.5 0.3 0.047 13.0 0.0 2.6 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 EKE41011.1 - 0.064 11.6 0.1 0.49 8.7 0.0 2.2 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF5122 PF17164.4 EKE41011.1 - 1.1 9.6 4.6 11 6.4 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF5122) beta-propeller EMP24_GP25L PF01105.24 EKE41012.1 - 1.3e-33 116.5 2.3 1.5e-33 116.3 2.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Thioredoxin PF00085.20 EKE41013.1 - 4.2e-08 33.1 0.2 5.6e-08 32.7 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EKE41013.1 - 0.0069 15.8 0.1 0.011 15.1 0.1 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Ribosomal_S2 PF00318.20 EKE41014.1 - 2.5e-23 82.5 0.2 2.9e-12 46.3 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Adaptin_N PF01602.20 EKE41015.1 - 1.5e-45 155.8 21.4 1.6e-45 155.6 21.4 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EKE41015.1 - 9.9e-15 54.9 1.7 9.9e-15 54.9 1.7 2.8 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKE41015.1 - 0.00021 21.6 0.0 0.05 14.0 0.0 2.3 1 1 2 3 3 3 3 HEAT repeats HEAT PF02985.22 EKE41015.1 - 0.0018 18.4 0.2 2.8 8.4 0.0 3.3 3 0 0 3 3 3 2 HEAT repeat WD40 PF00400.32 EKE41016.1 - 2.6e-09 37.5 7.9 8.1e-05 23.3 0.0 5.7 5 1 1 6 6 6 3 WD domain, G-beta repeat Cyanate_lyase PF02560.14 EKE41017.1 - 0.073 12.9 0.0 0.39 10.6 0.0 2.1 2 0 0 2 2 2 0 Cyanate lyase C-terminal domain TMEM131_like PF12371.8 EKE41017.1 - 0.082 13.2 0.2 0.17 12.1 0.2 1.5 1 0 0 1 1 1 0 Transmembrane protein 131-like MgtE PF01769.16 EKE41017.1 - 0.086 13.2 0.2 0.18 12.2 0.2 1.5 1 0 0 1 1 1 0 Divalent cation transporter TMIE PF16038.5 EKE41017.1 - 0.17 11.7 0.9 0.4 10.5 0.9 1.5 1 0 0 1 1 1 0 TMIE protein PEHE PF15275.6 EKE41018.1 - 0.00012 22.8 0.1 0.00012 22.8 0.1 2.3 2 0 0 2 2 2 1 PEHE domain YfhO PF09586.10 EKE41018.1 - 1.1 7.4 10.2 1.5 6.9 10.1 1.3 1 1 0 1 1 1 0 Bacterial membrane protein YfhO Pkinase_Tyr PF07714.17 EKE41019.1 - 2.7e-35 121.9 0.1 6.9e-35 120.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41019.1 - 1.4e-32 113.1 0.1 4.7e-32 111.4 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Myotub-related PF06602.14 EKE41019.1 - 3.4e-11 42.7 3.0 9.5e-11 41.2 3.0 1.8 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain LRR_4 PF12799.7 EKE41019.1 - 3.1e-08 33.8 36.5 0.0028 18.0 1.0 6.8 5 1 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE41019.1 - 2.9e-07 30.2 23.4 0.00016 21.3 1.6 4.8 3 1 0 4 4 4 3 Leucine rich repeat GRAM PF02893.20 EKE41019.1 - 0.016 15.1 3.0 0.036 13.9 0.4 2.9 2 0 0 2 2 2 0 GRAM domain RhoGAP PF00620.27 EKE41019.1 - 0.037 13.8 1.6 0.23 11.3 0.6 2.6 2 0 0 2 2 2 0 RhoGAP domain DUF4806 PF16064.5 EKE41019.1 - 0.5 10.7 6.8 5 7.5 0.0 4.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4806) MMPL PF03176.15 EKE41020.1 - 9.3e-68 228.6 8.1 6.9e-36 123.8 0.0 2.2 2 0 0 2 2 2 2 MMPL family DUF948 PF06103.11 EKE41020.1 - 0.12 12.7 3.9 3.4 8.0 1.9 3.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CRM1_repeat_2 PF18784.1 EKE41020.1 - 0.14 11.9 0.6 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 CRM1 / Exportin repeat 2 Sterol-sensing PF12349.8 EKE41020.1 - 0.54 10.1 27.2 0.52 10.1 2.8 4.3 4 2 1 5 5 5 0 Sterol-sensing domain of SREBP cleavage-activation NARP1 PF12569.8 EKE41021.1 - 3.8e-23 82.2 21.1 3.8e-23 82.2 21.1 2.2 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_19 PF14559.6 EKE41021.1 - 5.6e-14 52.4 9.1 0.031 14.8 0.2 6.5 5 2 1 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 EKE41021.1 - 4.5e-09 35.7 24.7 0.16 12.1 0.0 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE41021.1 - 6.7e-07 29.4 24.3 0.005 17.0 0.6 5.8 5 2 0 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EKE41021.1 - 2.1e-06 27.9 7.3 0.76 10.1 0.0 6.2 6 1 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 EKE41021.1 - 3.3e-06 26.7 25.9 0.082 12.8 1.1 7.9 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 EKE41021.1 - 3.4e-06 27.4 0.0 42 5.3 0.1 6.1 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EKE41021.1 - 4.7e-06 26.4 26.4 0.049 13.8 1.0 7.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 EKE41021.1 - 0.00073 20.1 0.0 39 5.0 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EKE41021.1 - 0.021 14.8 7.1 15 5.9 0.2 5.8 8 0 0 8 8 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EKE41021.1 - 0.067 13.9 13.3 3.2 8.6 0.2 6.6 8 0 0 8 8 7 0 Tetratricopeptide repeat ATP13 PF12921.7 EKE41021.1 - 0.069 13.0 13.5 0.62 9.9 0.2 6.1 6 1 2 8 8 8 0 Mitochondrial ATPase expression Fis1_TPR_C PF14853.6 EKE41021.1 - 0.097 12.8 19.3 0.4 10.8 0.7 5.5 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 EKE41021.1 - 0.6 9.8 8.8 20 5.0 0.3 5.5 6 1 1 7 7 7 0 TPR repeat TPR_17 PF13431.6 EKE41021.1 - 6 7.5 11.0 8.1 7.1 0.3 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Rap_GAP PF02145.15 EKE41022.1 - 4.6e-14 52.4 0.0 1.3e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 Rap/ran-GAP Cnd1 PF12717.7 EKE41022.1 - 0.088 12.9 1.8 5.7 7.0 0.0 3.9 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EKE41022.1 - 0.12 12.7 0.0 0.44 11.0 0.0 2.1 1 0 0 1 1 1 0 HEAT repeat CCDC-167 PF15188.6 EKE41022.1 - 0.58 10.5 3.1 1.2 9.5 0.5 2.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 TFIID-18kDa PF02269.16 EKE41023.1 - 3e-08 33.6 0.5 4.1e-08 33.2 0.5 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit DUF2653 PF10850.8 EKE41023.1 - 0.0036 17.5 0.2 0.92 9.8 0.0 2.3 2 1 0 2 2 2 2 Protein of unknown function (DUF2653) Ras PF00071.22 EKE41024.1 - 1.6e-35 122.1 0.0 2.4e-35 121.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41024.1 - 6.6e-12 45.7 0.0 1.1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41024.1 - 1.5e-05 24.5 0.0 2e-05 24.1 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family PIG-U PF06728.13 EKE41027.1 - 1.6e-14 53.8 29.0 1.6e-14 53.8 29.0 2.4 1 1 1 2 2 2 2 GPI transamidase subunit PIG-U RasGAP PF00616.19 EKE41028.1 - 2.1e-19 70.0 3.2 2e-12 47.2 0.1 5.0 3 2 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase Glycoprot_B_PH2 PF17417.2 EKE41028.1 - 0.0014 18.9 1.8 0.16 12.3 1.1 3.3 2 1 0 2 2 2 1 Herpesvirus Glycoprotein B PH-like domain Cwf_Cwc_15 PF04889.12 EKE41028.1 - 6.8 6.4 23.1 12 5.5 23.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein WD40 PF00400.32 EKE41029.1 - 4.6e-17 62.1 19.9 7e-05 23.5 0.2 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE41029.1 - 1.5e-11 44.4 0.1 0.0025 18.1 0.0 4.5 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EKE41029.1 - 0.044 12.4 0.0 0.074 11.7 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 PD40 PF07676.12 EKE41029.1 - 0.14 12.1 0.4 0.45 10.5 0.1 2.0 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat GSIII_N PF12437.8 EKE41030.1 - 3e-61 205.8 0.0 6.9e-61 204.6 0.0 1.7 1 0 0 1 1 1 1 Glutamine synthetase type III N terminal Gln-synt_C PF00120.24 EKE41030.1 - 6.1e-22 78.1 0.0 2.8e-20 72.6 0.0 2.4 3 0 0 3 3 3 2 Glutamine synthetase, catalytic domain Gln-synt_C-ter PF18318.1 EKE41030.1 - 8.5e-21 74.0 3.4 2e-20 72.8 3.4 1.7 1 0 0 1 1 1 1 Glutamine synthetase C-terminal domain Arg_repressor PF01316.21 EKE41031.1 - 0.00024 20.8 1.2 0.00045 19.9 0.3 1.9 2 0 0 2 2 2 1 Arginine repressor, DNA binding domain HTH_32 PF13565.6 EKE41031.1 - 0.034 14.7 0.0 0.54 10.9 0.0 2.2 1 1 1 2 2 2 0 Homeodomain-like domain MTP18 PF10558.9 EKE41031.1 - 0.092 12.7 0.3 0.45 10.5 0.1 1.9 1 1 0 2 2 2 0 Mitochondrial 18 KDa protein (MTP18) HTH_7 PF02796.15 EKE41031.1 - 1.1 9.4 5.6 0.46 10.6 1.0 2.5 2 1 0 2 2 2 0 Helix-turn-helix domain of resolvase PNP_UDP_1 PF01048.20 EKE41032.1 - 1.2e-31 109.8 0.2 1.4e-31 109.6 0.2 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily RRM_1 PF00076.22 EKE41033.1 - 2e-19 69.1 4.9 4.6e-09 36.0 0.4 4.1 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EKE41033.1 - 4.3e-05 23.8 0.9 0.95 9.7 0.3 3.4 3 0 0 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 EKE41033.1 - 0.00044 20.2 0.3 0.12 12.4 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EKE41033.1 - 0.0027 17.7 6.6 4.4 7.4 0.1 4.0 3 1 1 4 4 4 2 RNA binding motif RRM_5 PF13893.6 EKE41033.1 - 0.0028 17.2 0.3 0.0028 17.2 0.3 2.2 2 1 1 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G10 PF01125.17 EKE41033.1 - 0.058 13.2 0.8 0.14 11.9 0.8 1.7 1 0 0 1 1 1 0 G10 protein BRAP2 PF07576.12 EKE41033.1 - 0.087 13.0 0.2 0.34 11.2 0.1 2.0 3 0 0 3 3 3 0 BRCA1-associated protein 2 TOBE_3 PF12857.7 EKE41033.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 TOBE-like domain Arm PF00514.23 EKE41034.1 - 0.0016 18.4 0.0 0.93 9.6 0.0 4.1 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Ric8 PF10165.9 EKE41034.1 - 0.0042 16.2 4.8 0.059 12.4 1.1 2.7 2 1 0 2 2 2 2 Guanine nucleotide exchange factor synembryn DUF383 PF04063.14 EKE41034.1 - 0.11 12.1 7.4 0.06 13.0 2.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF383) FAE1_CUT1_RppA PF08392.12 EKE41035.1 - 2.6e-95 319.1 0.0 3.3e-95 318.7 0.0 1.1 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.10 EKE41035.1 - 2.7e-10 40.3 0.0 1.5e-09 37.9 0.0 2.2 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Chal_sti_synt_C PF02797.15 EKE41035.1 - 6.5e-09 35.9 0.0 2.1e-08 34.3 0.0 1.9 1 1 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EKE41035.1 - 0.0046 16.4 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III PF08545.10 EKE41035.1 - 0.02 14.7 0.0 0.065 13.1 0.0 1.8 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MMtag PF10159.9 EKE41036.1 - 0.11 12.7 9.5 1.7 9.0 9.5 2.2 1 1 0 1 1 1 0 Multiple myeloma tumor-associated DAP_B PF07930.12 EKE41036.1 - 0.16 11.9 0.7 0.19 11.7 0.7 1.1 1 0 0 1 1 1 0 D-aminopeptidase, domain B RhoGEF PF00621.20 EKE41037.1 - 1.9e-41 142.3 3.0 1.9e-41 142.3 3.0 2.0 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 EKE41037.1 - 1.3e-14 54.0 9.2 1.3e-14 54.0 9.2 2.0 2 0 0 2 2 2 1 FYVE zinc finger PH PF00169.29 EKE41037.1 - 2.5e-09 37.6 0.2 1.5e-08 35.1 0.1 2.4 3 0 0 3 3 3 1 PH domain FYVE_2 PF02318.16 EKE41037.1 - 3.5e-05 24.0 9.0 9.8e-05 22.6 9.0 1.8 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.5 EKE41037.1 - 0.0052 16.6 1.3 0.5 10.2 0.1 3.4 2 1 1 3 3 3 1 Pleckstrin homology domain DZR PF12773.7 EKE41037.1 - 0.35 10.9 11.2 6 7.0 1.6 2.6 1 1 1 2 2 2 0 Double zinc ribbon A_thal_3526 PF09713.10 EKE41038.1 - 2.1e-13 50.3 0.8 2.1e-13 50.3 0.8 1.8 2 0 0 2 2 2 1 Plant protein 1589 of unknown function (A_thal_3526) Nyv1_N PF09426.10 EKE41038.1 - 0.026 14.5 0.1 0.036 14.1 0.1 1.2 1 0 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal Pex24p PF06398.11 EKE41040.1 - 0.67 8.9 0.0 0.67 8.9 0.0 2.1 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin DUF2204 PF09970.9 EKE41042.1 - 0.011 15.4 0.1 0.056 13.1 0.0 2.2 2 0 0 2 2 2 0 Nucleotidyl transferase of unknown function (DUF2204) DUF1827 PF08860.10 EKE41042.1 - 0.031 14.5 0.2 0.12 12.7 0.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1827) Rap_GAP PF02145.15 EKE41043.1 - 7e-25 87.7 0.2 3.4e-24 85.4 0.0 2.2 2 0 0 2 2 2 1 Rap/ran-GAP Cnd3 PF12719.7 EKE41043.1 - 0.095 11.9 1.5 0.98 8.5 0.0 3.0 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain DUF4313 PF14190.6 EKE41044.1 - 0.63 10.1 3.2 3.7 7.6 1.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4313) NFACT-R_1 PF05670.13 EKE41045.1 - 4.9e-40 136.6 0.0 8.2e-40 135.8 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain Ank_2 PF12796.7 EKE41046.1 - 6.2e-12 45.9 0.3 2.1e-05 25.0 0.6 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE41046.1 - 1.5e-11 44.6 0.2 0.00013 22.4 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE41046.1 - 2.4e-10 40.4 0.0 4.2e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE41046.1 - 5.6e-10 38.6 0.1 0.00043 20.5 0.1 4.5 4 0 0 4 4 4 2 Ankyrin repeat Patatin PF01734.22 EKE41046.1 - 1.4e-09 38.4 0.0 2.6e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase Ank PF00023.30 EKE41046.1 - 2.4e-07 30.9 0.0 0.00055 20.3 0.3 4.0 4 0 0 4 4 4 1 Ankyrin repeat PH_10 PF15411.6 EKE41047.1 - 0.021 15.1 3.5 0.045 14.0 0.2 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain HTH_54 PF18607.1 EKE41047.1 - 0.061 13.4 0.4 1.1 9.3 0.0 2.5 2 0 0 2 2 2 0 ParA helix turn helix domain WWE PF02825.20 EKE41047.1 - 0.063 13.9 0.1 0.063 13.9 0.1 2.8 3 0 0 3 3 3 0 WWE domain BRCT_2 PF16589.5 EKE41047.1 - 1.5 9.2 7.4 0.11 12.9 0.7 2.5 3 0 0 3 3 3 0 BRCT domain, a BRCA1 C-terminus domain Mit_KHE1 PF10173.9 EKE41047.1 - 1.8 8.6 4.4 4.9 7.2 0.2 2.4 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related PGM_PMM_I PF02878.16 EKE41048.1 - 2.3e-29 101.9 0.0 9.6e-29 99.9 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EKE41048.1 - 6.9e-25 87.7 0.0 2.5e-24 85.8 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EKE41048.1 - 5.6e-21 74.9 0.0 1.1e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EKE41048.1 - 3.1e-09 36.9 0.1 1.8e-08 34.4 0.2 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Saccharop_dh_N PF04455.12 EKE41048.1 - 0.099 13.1 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region DUF384 PF04064.13 EKE41048.1 - 0.14 12.0 0.0 0.41 10.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF384) CK_II_beta PF01214.18 EKE41049.1 - 1e-28 100.4 1.0 1.4e-28 99.9 1.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit NAP PF00956.18 EKE41050.1 - 1.5e-15 57.1 2.9 8e-14 51.5 0.3 2.1 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Cofilin_ADF PF00241.20 EKE41051.1 - 8.3e-40 135.4 0.0 4.9e-22 78.0 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein KCNQ2_u3 PF16642.5 EKE41052.1 - 0.03 15.3 0.7 0.054 14.5 0.7 1.5 1 0 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 SCAI PF12070.8 EKE41053.1 - 2.6e-86 290.6 24.7 1.6e-51 175.8 7.0 3.5 1 1 2 3 3 3 3 Protein SCAI Seryl_tRNA_N PF02403.22 EKE41054.1 - 0.0073 16.5 12.2 0.0073 16.5 12.2 10.1 2 1 8 10 10 10 1 Seryl-tRNA synthetase N-terminal domain DUF2205 PF10224.9 EKE41054.1 - 0.013 15.4 3.3 0.013 15.4 3.3 6.9 6 2 0 7 7 7 0 Short coiled-coil protein DUF2087 PF09860.9 EKE41054.1 - 7 6.9 9.5 0.45 10.7 0.2 3.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2087) MFS_1 PF07690.16 EKE41055.1 - 8.5e-22 77.5 39.8 7.1e-19 67.9 31.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 EKE41055.1 - 1.1e-19 70.8 10.6 1.1e-19 70.8 10.6 3.3 2 2 0 2 2 2 1 Ion channel regulatory protein UNC-93 Pkinase PF00069.25 EKE41056.1 - 4.2e-70 236.1 0.0 7.2e-70 235.4 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41056.1 - 1.9e-29 102.7 0.0 3e-29 102.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE41056.1 - 3.3e-08 33.2 0.0 5.3e-08 32.5 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EKE41056.1 - 0.00086 18.2 0.0 0.0016 17.3 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Ribosomal_60s PF00428.19 EKE41057.1 - 4.9e-19 68.7 18.9 5.5e-19 68.5 18.9 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein PepSY_2 PF13670.6 EKE41057.1 - 0.0031 17.5 4.7 0.3 11.1 1.0 2.2 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain DUF3824 PF12868.7 EKE41057.1 - 0.048 14.3 5.1 0.067 13.8 5.1 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) MOZART2 PF12926.7 EKE41057.1 - 0.081 12.5 0.9 0.099 12.3 0.5 1.5 1 1 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated Cytomega_UL84 PF06284.11 EKE41057.1 - 0.17 10.3 2.4 0.19 10.1 2.4 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Cofilin_ADF PF00241.20 EKE41058.1 - 2.4e-12 46.7 0.0 2.9e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Piwi PF02171.17 EKE41059.1 - 1.8e-46 158.8 8.1 5.3e-46 157.2 8.1 1.8 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 EKE41059.1 - 5.3e-18 65.2 2.4 5.3e-18 65.2 2.4 2.5 2 0 0 2 2 2 1 PAZ domain DUF1854 PF08909.11 EKE41059.1 - 0.006 16.4 0.9 2.6 7.9 0.2 2.7 2 1 0 2 2 2 2 Domain of unknown function (DUF1854) ArgoL1 PF08699.10 EKE41059.1 - 0.0064 16.1 0.3 0.015 15.0 0.3 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain DPPIV_rep PF18811.1 EKE41059.1 - 0.22 11.5 3.5 25 5.0 1.5 3.7 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) low complexity region Voltage_CLC PF00654.20 EKE41060.1 - 4.5e-64 216.9 30.1 4.5e-64 216.9 30.1 2.0 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EKE41060.1 - 0.0014 19.1 0.1 0.2 12.2 0.1 2.5 2 0 0 2 2 2 2 CBS domain DnaJ_C PF01556.18 EKE41061.1 - 0.009 16.1 1.5 0.27 11.3 0.3 2.7 2 1 0 2 2 2 1 DnaJ C terminal domain PfUIS3 PF11567.8 EKE41061.1 - 0.02 15.3 1.2 0.048 14.0 0.7 1.9 2 0 0 2 2 2 0 Plasmodium falciparum UIS3 membrane protein DPPIV_rep PF18811.1 EKE41061.1 - 3.8 7.6 6.1 1.1 9.3 0.1 3.3 4 0 0 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) low complexity region TSGA13 PF14994.6 EKE41062.1 - 0.014 14.8 1.1 0.018 14.4 1.1 1.1 1 0 0 1 1 1 0 Testis-specific gene 13 protein DUF1647 PF07801.11 EKE41062.1 - 0.027 14.2 0.6 0.027 14.2 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) Ebp2 PF05890.12 EKE41064.1 - 6.2e-28 98.1 35.9 1.2e-27 97.2 35.9 1.4 1 1 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 DUF4315 PF14193.6 EKE41064.1 - 0.0066 16.4 6.2 0.0066 16.4 6.2 3.3 2 1 0 3 3 3 1 Domain of unknown function (DUF4315) CorA PF01544.18 EKE41064.1 - 2.2 7.5 5.1 3.2 7.0 5.1 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF4407 PF14362.6 EKE41064.1 - 3.8 6.8 9.6 4.4 6.6 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Muted PF14942.6 EKE41064.1 - 4.8 7.5 23.1 3.5 8.0 1.4 2.2 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Importin_rep_4 PF18808.1 EKE41064.1 - 5.7 7.3 6.6 2.7 8.3 0.9 2.3 2 0 0 2 2 2 0 Importin repeat VWA_3 PF13768.6 EKE41065.1 - 0.0015 18.5 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Nitro_FeMo-Co PF02579.17 EKE41065.1 - 0.13 12.6 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor Metallophos PF00149.28 EKE41066.1 - 7e-13 49.5 0.4 1e-12 49.0 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE41066.1 - 0.00046 20.4 0.0 0.0035 17.6 0.0 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain AMP-binding PF00501.28 EKE41067.1 - 3.3e-83 279.7 0.0 4.9e-83 279.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EKE41067.1 - 0.0086 17.0 0.2 0.028 15.4 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DUF987 PF06174.11 EKE41067.1 - 0.25 11.3 0.8 1.8 8.5 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF987) tRNA_anti-codon PF01336.25 EKE41068.1 - 1.4e-07 31.4 1.3 2.2e-07 30.8 1.3 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 EKE41068.1 - 4.9e-07 29.6 0.4 6.3e-07 29.3 0.4 1.1 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 BOF PF04076.13 EKE41068.1 - 0.072 13.2 0.5 0.072 13.2 0.5 1.7 2 0 0 2 2 2 0 Bacterial OB fold (BOF) protein MatB PF16449.5 EKE41068.1 - 0.081 12.7 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Fimbrillin MatB DUF4131 PF13567.6 EKE41068.1 - 0.16 11.6 0.0 0.32 10.6 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) Sulfotransfer_3 PF13469.6 EKE41069.1 - 2.2e-30 106.7 0.1 3.3e-30 106.1 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EKE41069.1 - 3.4e-07 30.0 0.6 8.4e-07 28.7 0.6 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_4 PF17784.1 EKE41069.1 - 0.0094 15.8 1.2 0.091 12.6 0.3 2.3 2 0 0 2 2 2 1 Sulfotransferase domain TPR_1 PF00515.28 EKE41070.1 - 2.7e-16 58.6 16.1 9.9e-06 25.2 1.6 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EKE41070.1 - 1.1e-14 53.2 12.5 8.8e-05 22.3 0.5 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EKE41070.1 - 6.3e-08 32.2 14.3 0.026 14.7 1.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EKE41070.1 - 9.2e-08 31.7 16.9 3.5e-05 23.4 1.8 3.4 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.6 EKE41070.1 - 1.1e-05 25.5 8.7 1.6e-05 24.9 0.7 4.2 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EKE41070.1 - 4.3e-05 23.9 1.9 4.3e-05 23.9 1.9 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EKE41070.1 - 0.0002 21.9 0.7 0.23 12.4 0.1 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EKE41070.1 - 0.002 18.7 3.7 0.31 11.7 0.4 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EKE41070.1 - 0.0032 17.7 6.6 0.047 14.0 3.5 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EKE41070.1 - 0.008 16.2 3.5 0.031 14.3 0.0 3.3 3 1 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EKE41070.1 - 0.056 13.3 5.3 1.1 9.2 0.2 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat MFS_1 PF07690.16 EKE41071.1 - 5.5e-30 104.5 6.9 2.5e-24 85.9 4.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 EKE41071.1 - 0.0012 17.2 1.1 0.0016 16.8 0.0 1.7 2 1 0 2 2 2 1 BT1 family DUF4047 PF13256.6 EKE41071.1 - 0.41 10.8 3.6 0.55 10.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) RhoGAP PF00620.27 EKE41072.1 - 6e-12 45.6 1.6 8.6e-12 45.1 1.2 1.5 1 1 1 2 2 2 1 RhoGAP domain RhoGAP PF00620.27 EKE41073.1 - 1.5e-12 47.6 0.0 2e-12 47.2 0.0 1.2 1 1 0 1 1 1 1 RhoGAP domain DKCLD PF08068.12 EKE41074.1 - 1.2e-30 105.4 0.1 1.8e-28 98.3 0.1 2.6 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EKE41074.1 - 9e-23 80.2 0.7 1.7e-22 79.3 0.7 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 EKE41074.1 - 9.2e-23 81.3 6.1 4.6e-21 75.8 0.2 3.9 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EKE41074.1 - 1.3e-19 69.9 1.2 2.9e-19 68.8 1.2 1.6 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EKE41074.1 - 0.00028 21.1 0.2 0.0017 18.6 0.1 2.3 2 0 0 2 2 2 1 UPF0113 PUA domain Macoilin PF09726.9 EKE41074.1 - 7.9 4.9 27.3 11 4.5 27.3 1.1 1 0 0 1 1 1 0 Macoilin family DUF4083 PF13314.6 EKE41075.1 - 1.1e-05 25.2 3.2 0.0002 21.3 0.3 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4083) Saf_2TM PF18303.1 EKE41075.1 - 4e-05 23.3 0.1 6.4e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 SAVED-fused 2TM effector domain Ninjurin PF04923.12 EKE41075.1 - 0.0071 16.3 0.1 0.012 15.5 0.1 1.5 1 0 0 1 1 1 1 Ninjurin Tetraspanin PF00335.20 EKE41075.1 - 0.0073 16.0 0.8 0.0073 16.0 0.8 1.9 1 1 0 2 2 2 1 Tetraspanin family LapA_dom PF06305.11 EKE41075.1 - 0.0079 16.0 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain S1FA PF04689.13 EKE41075.1 - 0.017 15.3 0.2 0.017 15.3 0.2 1.8 2 0 0 2 2 2 0 DNA binding protein S1FA DUF1673 PF07895.11 EKE41075.1 - 0.021 14.5 0.7 0.031 14.0 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Neur_chan_memb PF02932.16 EKE41075.1 - 0.024 14.7 0.1 0.042 13.9 0.0 1.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DiS_P_DiS PF06750.13 EKE41075.1 - 0.028 14.5 2.0 0.083 13.0 2.0 1.8 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain PspB PF06667.12 EKE41075.1 - 0.043 13.9 0.1 0.084 12.9 0.1 1.6 1 0 0 1 1 1 0 Phage shock protein B PepSY_TM_like_2 PF16357.5 EKE41075.1 - 0.045 13.7 0.0 0.057 13.4 0.0 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like GRIM-19 PF06212.12 EKE41075.1 - 0.057 13.4 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 GRIM-19 protein ArsP_1 PF03773.13 EKE41075.1 - 0.078 12.1 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Predicted permease EphA2_TM PF14575.6 EKE41075.1 - 0.08 13.8 0.1 0.19 12.6 0.0 1.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain RIFIN PF02009.16 EKE41075.1 - 0.14 12.0 10.5 0.049 13.5 6.7 2.1 1 1 0 1 1 1 0 Rifin SIT PF15330.6 EKE41075.1 - 0.16 12.4 1.3 0.22 12.0 0.1 1.8 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Tmemb_9 PF05434.11 EKE41075.1 - 2.3 8.1 8.0 1.2 9.0 6.1 1.6 1 1 0 1 1 1 0 TMEM9 Insulin_TMD PF17870.1 EKE41075.1 - 4.4 7.5 6.1 0.94 9.6 1.2 2.1 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Aa_trans PF01490.18 EKE41076.1 - 3.1e-47 161.2 43.0 3.9e-47 160.9 43.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EKE41076.1 - 9.4e-06 24.9 19.8 9.4e-06 24.9 19.8 2.3 1 1 0 2 2 2 1 Tryptophan/tyrosine permease family Casc1_N PF15927.5 EKE41077.1 - 0.017 14.8 5.1 0.079 12.6 0.4 3.0 2 1 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus ADAM_spacer1 PF05986.14 EKE41078.1 - 1.7 8.7 5.0 2 8.5 0.0 3.7 4 0 0 4 4 4 0 ADAM-TS Spacer 1 CryBP1 PF07029.11 EKE41078.1 - 5.5 7.1 11.4 0.15 12.2 1.7 3.4 3 1 0 3 3 3 0 CryBP1 protein SNF2_N PF00176.23 EKE41080.1 - 2.4e-63 214.0 1.6 3.6e-63 213.4 1.6 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE41080.1 - 9.8e-17 61.3 0.0 4.7e-16 59.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Chromo PF00385.24 EKE41080.1 - 1.9e-14 53.3 6.1 1.4e-11 44.1 1.7 3.6 4 0 0 4 4 4 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 EKE41080.1 - 1.6e-07 31.5 0.2 8.7e-07 29.1 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EKE41080.1 - 1.5e-06 27.6 4.0 5.6e-06 25.7 0.2 2.6 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 AAA_22 PF13401.6 EKE41080.1 - 0.00067 19.9 0.0 0.0026 18.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain SWI2_SNF2 PF18766.1 EKE41080.1 - 0.026 14.2 0.0 0.07 12.8 0.0 1.7 1 0 0 1 1 1 0 SWI2/SNF2 ATPase AAA_19 PF13245.6 EKE41080.1 - 0.11 12.9 0.0 0.3 11.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain Cornichon PF03311.14 EKE41081.1 - 2.7e-20 72.9 11.9 3.5e-20 72.6 11.9 1.1 1 0 0 1 1 1 1 Cornichon protein RTC PF01137.21 EKE41083.1 - 2.5e-51 174.0 0.1 2.8e-51 173.8 0.1 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EKE41083.1 - 4.3e-31 107.5 0.0 6.6e-31 106.9 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Peptidase_M24 PF00557.24 EKE41084.1 - 1.7e-42 145.5 0.0 2.4e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 EKE41084.1 - 4.8e-25 88.5 0.0 2.7e-24 86.1 0.0 2.2 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 EKE41084.1 - 3.8e-17 62.1 0.3 8.7e-17 60.9 0.3 1.6 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EKE41084.1 - 6.3e-09 36.6 0.0 1.6e-07 32.1 0.0 2.3 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain HAD_2 PF13419.6 EKE41085.1 - 5.6e-11 42.8 0.0 7.1e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EKE41085.1 - 0.0015 18.5 0.0 0.0025 17.8 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Imm68 PF15583.6 EKE41085.1 - 0.0022 18.2 0.1 0.0036 17.5 0.1 1.3 1 0 0 1 1 1 1 Immunity protein 68 Hydrolase PF00702.26 EKE41085.1 - 0.0032 17.8 0.0 0.0044 17.3 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3578 PF12102.8 EKE41086.1 - 0.57 9.7 4.1 2.2 7.8 4.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3578) Rap_GAP PF02145.15 EKE41089.1 - 1.1e-51 175.0 1.1 3.4e-51 173.5 1.1 1.9 1 0 0 1 1 1 1 Rap/ran-GAP Ank_2 PF12796.7 EKE41089.1 - 3.3e-35 120.5 23.8 7.3e-10 39.3 0.1 3.6 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKE41089.1 - 3.7e-20 69.9 2.5 0.0049 17.3 0.1 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 EKE41089.1 - 6.9e-18 64.5 0.1 7.7e-07 29.3 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EKE41089.1 - 1.8e-17 63.4 0.5 7.1e-06 26.5 0.1 4.6 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EKE41089.1 - 1.4e-14 53.8 2.6 0.011 16.2 0.4 5.1 4 1 0 4 4 4 3 Ankyrin repeat bZIP_2 PF07716.15 EKE41089.1 - 0.052 13.6 0.5 0.13 12.4 0.5 1.6 1 0 0 1 1 1 0 Basic region leucine zipper MscS_porin PF12795.7 EKE41089.1 - 0.054 13.0 1.2 0.099 12.2 1.2 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain SWIB PF02201.18 EKE41089.1 - 0.071 13.0 0.3 0.43 10.5 0.1 2.4 2 0 0 2 2 2 0 SWIB/MDM2 domain YabA PF06156.13 EKE41089.1 - 1.6 9.4 4.3 4.6 7.9 0.1 3.2 3 0 0 3 3 3 0 Initiation control protein YabA UCH PF00443.29 EKE41090.1 - 3.8e-46 157.7 9.9 4.8e-46 157.3 9.9 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE41090.1 - 8.2e-08 32.2 11.6 4.6e-07 29.7 11.6 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase TLD PF07534.16 EKE41091.1 - 0.0043 17.3 0.8 0.021 15.0 0.2 2.2 2 0 0 2 2 2 1 TLD AAA_14 PF13173.6 EKE41091.1 - 0.021 14.9 3.0 2.1 8.4 3.0 2.3 1 1 0 1 1 1 0 AAA domain PriX PF18689.1 EKE41091.1 - 0.21 11.9 3.3 1 9.7 0.0 2.4 2 0 0 2 2 2 0 Primase X COG2 PF06148.11 EKE41092.1 - 2e-10 40.9 5.8 4.6e-10 39.7 5.7 1.6 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 KdpD PF02702.17 EKE41092.1 - 0.018 14.5 2.0 0.03 13.8 1.8 1.4 1 1 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain DUF3835 PF12927.7 EKE41092.1 - 0.06 14.2 0.8 0.12 13.2 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3835) UvrD-helicase PF00580.21 EKE41092.1 - 0.074 12.6 5.3 0.089 12.3 5.3 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Pro_CA PF00484.19 EKE41092.1 - 0.18 12.1 2.4 0.23 11.7 2.0 1.4 1 1 0 1 1 1 0 Carbonic anhydrase DUF3349 PF11829.8 EKE41092.1 - 0.32 11.8 2.9 0.54 11.1 1.4 2.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) Actin PF00022.19 EKE41093.1 - 1.4e-98 330.2 0.0 3.8e-97 325.5 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EKE41093.1 - 3.6e-08 32.6 0.0 2.9e-07 29.6 0.0 2.2 1 1 0 1 1 1 1 MreB/Mbl protein Robl_LC7 PF03259.17 EKE41094.1 - 0.00032 20.4 0.0 0.0092 15.7 0.0 2.5 2 1 1 3 3 3 1 Roadblock/LC7 domain DUF4127 PF13552.6 EKE41094.1 - 0.13 10.8 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) DUF5409 PF17421.2 EKE41095.1 - 0.01 16.5 0.5 0.014 16.1 0.4 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5409) MIF4G_like_2 PF09090.11 EKE41096.1 - 0.00093 18.7 2.6 0.003 17.1 2.6 1.9 1 0 0 1 1 1 1 MIF4G like Dimer_Tnp_hAT PF05699.14 EKE41097.1 - 0.022 14.6 0.3 0.084 12.7 0.3 2.0 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region Ion_trans_2 PF07885.16 EKE41099.1 - 1.7e-13 50.3 5.2 1.7e-13 50.3 5.2 2.4 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.31 EKE41099.1 - 4.5e-09 35.9 25.9 4.5e-09 35.9 25.9 2.0 2 0 0 2 2 2 1 Ion transport protein TrkA_N PF02254.18 EKE41099.1 - 1.2e-08 35.1 0.0 0.00054 20.2 0.4 2.6 2 0 0 2 2 2 2 TrkA-N domain TrkA_C PF02080.21 EKE41099.1 - 0.0022 17.8 0.0 1.8 8.5 0.0 3.1 3 0 0 3 3 3 2 TrkA-C domain DUF2179 PF10035.9 EKE41099.1 - 0.06 13.1 0.9 0.31 10.8 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2179) A_deaminase PF00962.22 EKE41100.1 - 3.1e-74 250.3 0.2 3.4e-74 250.1 0.2 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 EKE41100.1 - 0.00054 19.4 0.2 0.00067 19.1 0.2 1.3 1 0 0 1 1 1 1 Amidohydrolase family TLD PF07534.16 EKE41101.1 - 0.0015 18.8 0.2 0.0015 18.8 0.2 2.1 2 1 0 2 2 2 1 TLD Mut7-C PF01927.16 EKE41102.1 - 5.7e-27 94.6 0.2 7.4e-27 94.3 0.2 1.1 1 0 0 1 1 1 1 Mut7-C RNAse domain DUF5615 PF18480.1 EKE41102.1 - 8.1e-05 22.3 0.0 0.00013 21.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5615) zf-UBP PF02148.19 EKE41102.1 - 0.0074 16.6 0.5 0.014 15.7 0.5 1.4 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein ADK_lid PF05191.14 EKE41102.1 - 0.054 13.5 0.6 5.9 7.0 0.1 2.4 2 0 0 2 2 2 0 Adenylate kinase, active site lid RT_RNaseH PF17917.1 EKE41102.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase zf-C2H2_2 PF12756.7 EKE41102.1 - 0.19 12.1 3.2 11 6.4 0.2 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-RanBP PF00641.18 EKE41102.1 - 3.4 7.1 8.2 0.44 9.9 0.4 2.3 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Pkinase PF00069.25 EKE41103.1 - 5.3e-35 121.1 0.6 1e-34 120.1 0.6 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41103.1 - 1.2e-29 103.4 1.3 1.5e-29 103.1 0.6 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase ASH PF15780.5 EKE41103.1 - 0.0082 16.3 0.4 0.023 14.9 0.2 1.8 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Pkinase_fungal PF17667.1 EKE41103.1 - 0.04 12.7 0.0 0.072 11.9 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase DUF4493 PF14900.6 EKE41103.1 - 0.052 13.4 0.7 0.11 12.4 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4493) Kdo PF06293.14 EKE41103.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Patatin PF01734.22 EKE41104.1 - 7.9e-12 45.8 0.1 1.6e-11 44.7 0.1 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase DUF4939 PF16297.5 EKE41104.1 - 0.12 12.3 0.1 0.37 10.7 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4939) MMR_HSR1_Xtn PF16897.5 EKE41105.1 - 8.1e-26 90.1 1.0 1.7e-25 89.1 1.0 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EKE41105.1 - 2.4e-10 40.3 0.0 4.8e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EKE41105.1 - 4.1e-08 33.3 0.2 9.6e-08 32.1 0.2 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE41105.1 - 3.9e-05 23.6 0.4 0.074 13.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EKE41105.1 - 0.00042 19.8 0.3 0.0025 17.3 0.0 2.1 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit NB-ARC PF00931.22 EKE41105.1 - 0.00068 18.9 0.0 0.0014 17.8 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 EKE41105.1 - 0.0011 19.5 0.7 0.0021 18.6 0.7 1.7 1 1 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 EKE41105.1 - 0.007 16.9 0.2 0.014 16.0 0.2 1.6 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EKE41105.1 - 0.015 14.8 0.8 0.037 13.6 0.1 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B GTP_EFTU PF00009.27 EKE41105.1 - 0.038 13.5 0.2 4.1 6.9 0.1 2.8 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Roc PF08477.13 EKE41105.1 - 0.039 14.2 0.1 0.19 12.0 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EKE41105.1 - 0.067 13.6 0.1 0.14 12.6 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 EKE41105.1 - 0.19 11.3 4.1 7.9 6.0 4.1 2.6 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Mob1_phocein PF03637.17 EKE41106.1 - 2.3e-67 226.2 0.3 2.8e-67 226.0 0.3 1.1 1 0 0 1 1 1 1 Mob1/phocein family Fe_hyd_lg_C PF02906.14 EKE41107.1 - 3.8e-44 151.2 4.4 5.4e-44 150.7 4.4 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain PDGF PF00341.17 EKE41107.1 - 0.34 11.2 4.5 0.23 11.8 0.5 2.5 2 0 0 2 2 2 0 PDGF/VEGF domain zf-C3HC4_3 PF13920.6 EKE41108.1 - 4.7e-06 26.4 9.6 4.7e-06 26.4 9.6 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EKE41108.1 - 9.9e-05 21.9 9.3 0.00018 21.0 9.3 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 EKE41108.1 - 0.00042 20.1 8.8 0.00042 20.1 8.8 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EKE41108.1 - 0.00088 19.1 10.5 0.00088 19.1 10.5 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EKE41108.1 - 0.0023 17.9 11.4 0.0023 17.9 11.4 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EKE41108.1 - 0.014 15.7 11.3 0.014 15.7 11.3 2.1 2 1 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 EKE41108.1 - 0.014 15.4 8.5 0.015 15.3 5.7 2.4 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EKE41108.1 - 0.062 13.5 14.9 0.41 10.8 12.7 2.8 1 1 2 3 3 3 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EKE41108.1 - 0.34 10.8 14.6 0.053 13.4 10.2 2.0 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 EKE41108.1 - 0.78 9.8 11.3 1.5 8.9 11.3 1.5 1 1 0 1 1 1 0 Double zinc ribbon Sep15_SelM PF08806.11 EKE41109.1 - 0.00052 20.1 0.1 0.00067 19.8 0.1 1.1 1 0 0 1 1 1 1 Sep15/SelM redox domain Pkinase PF00069.25 EKE41110.1 - 4.6e-31 108.1 0.1 5.6e-31 107.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41110.1 - 1.8e-16 60.2 0.0 2.2e-16 60.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE41110.1 - 7.6e-09 34.8 0.1 1.1e-08 34.3 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKE41110.1 - 2.3e-05 24.4 0.0 0.0022 17.9 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EKE41110.1 - 0.016 14.5 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 EKE41110.1 - 0.091 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 ABC1 family DnaJ_C PF01556.18 EKE41111.1 - 3e-26 92.3 0.8 3.8e-26 92.0 0.8 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EKE41111.1 - 1.4e-12 47.8 13.1 2.5e-12 46.9 13.1 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EKE41111.1 - 3.1e-06 27.0 17.3 0.00048 20.0 3.7 3.3 1 1 1 3 3 3 2 Tryptophan RNA-binding attenuator protein inhibitory protein zf-WRNIP1_ubi PF18279.1 EKE41111.1 - 0.067 13.9 2.4 1 10.1 0.3 2.7 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain TackOD1 PF18551.1 EKE41111.1 - 0.095 12.4 8.1 0.91 9.2 0.6 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zf-RVT PF13966.6 EKE41111.1 - 0.12 13.1 2.3 0.49 11.1 0.3 2.2 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase zf-RING_10 PF16685.5 EKE41111.1 - 0.31 11.2 4.2 2.9 8.1 0.2 2.3 1 1 1 2 2 2 0 zinc RING finger of MSL2 zf-H2C2_2 PF13465.6 EKE41111.1 - 1.1 9.8 6.4 38 4.9 0.0 4.0 4 0 0 4 4 4 0 Zinc-finger double domain DZR PF12773.7 EKE41111.1 - 1.2 9.2 8.0 5.5 7.1 8.0 2.0 1 1 0 1 1 1 0 Double zinc ribbon Lar_restr_allev PF14354.6 EKE41111.1 - 8.3 6.9 12.5 34 4.9 6.5 3.6 1 1 1 2 2 2 0 Restriction alleviation protein Lar DUF1356 PF07092.12 EKE41111.1 - 9.7 5.4 6.7 28 3.9 1.7 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1356) PMI_typeI PF01238.21 EKE41112.1 - 2.1e-41 142.3 2.6 2.8e-37 128.8 2.6 3.0 1 1 0 1 1 1 1 Phosphomannose isomerase type I DNA_alkylation PF08713.11 EKE41113.1 - 4.3e-25 88.7 0.0 5.4e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 DNA alkylation repair enzyme RTP1_C1 PF10363.9 EKE41113.1 - 0.14 12.3 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 Hexokinase_1 PF00349.21 EKE41114.1 - 4.2e-09 36.6 0.0 4.5e-09 36.5 0.0 1.0 1 0 0 1 1 1 1 Hexokinase ThiF PF00899.21 EKE41115.1 - 5e-64 216.0 0.0 1e-63 215.0 0.0 1.4 1 1 1 2 2 2 1 ThiF family E2_bind PF08825.10 EKE41115.1 - 3.1e-16 59.3 0.1 5e-16 58.6 0.1 1.3 1 0 0 1 1 1 1 E2 binding domain UAE_UbL PF14732.6 EKE41115.1 - 0.0021 18.6 0.0 0.0052 17.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Shikimate_DH PF01488.20 EKE41115.1 - 0.0048 17.0 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EKE41115.1 - 0.028 15.0 0.1 0.089 13.4 0.1 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1180 PF06679.12 EKE41116.1 - 0.031 14.7 0.8 0.049 14.1 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Stk19 PF10494.9 EKE41117.1 - 4.4e-08 33.1 0.3 9.1e-08 32.1 0.2 1.5 1 1 0 1 1 1 1 Serine-threonine protein kinase 19 DUF4870 PF09685.10 EKE41118.1 - 6.5e-06 26.2 8.9 7.6e-06 26.0 8.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4870) DUF2834 PF11196.8 EKE41118.1 - 0.02 15.2 2.6 0.02 15.2 2.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2834) DUF2721 PF11026.8 EKE41118.1 - 2.3 8.1 14.5 0.45 10.4 8.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) Cornichon PF03311.14 EKE41119.1 - 4.5e-29 101.3 8.6 6e-29 100.9 8.6 1.2 1 0 0 1 1 1 1 Cornichon protein PIG-Y PF15159.6 EKE41119.1 - 1.5 9.8 9.0 2 9.4 3.0 2.3 1 1 1 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y TLD PF07534.16 EKE41120.1 - 0.00011 22.4 2.0 0.00018 21.8 0.8 1.9 2 0 0 2 2 2 1 TLD Ras PF00071.22 EKE41121.1 - 5e-39 133.5 0.4 4e-37 127.3 0.4 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EKE41121.1 - 8e-17 61.6 0.0 1.3e-16 60.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41121.1 - 0.00037 20.0 0.1 0.00041 19.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE41121.1 - 0.0039 17.2 0.1 0.0058 16.7 0.1 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE41121.1 - 0.026 14.1 0.3 0.065 12.8 0.2 1.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain SNARE_assoc PF09335.11 EKE41123.1 - 7e-22 78.2 4.3 7e-22 78.2 4.3 2.3 3 1 0 3 3 3 1 SNARE associated Golgi protein DUF996 PF06195.13 EKE41123.1 - 0.0006 20.1 1.6 0.0006 20.1 1.6 3.1 2 1 0 2 2 2 1 Protein of unknown function (DUF996) Ephrin_rec_like PF07699.13 EKE41124.1 - 2e-07 30.6 7.1 2e-07 30.6 7.1 6.6 2 2 3 5 5 5 3 Putative ephrin-receptor like NCD3G PF07562.14 EKE41124.1 - 0.0041 17.1 55.2 0.092 12.7 2.9 6.8 2 2 7 9 9 9 8 Nine Cysteines Domain of family 3 GPCR Cadherin_C_2 PF16492.5 EKE41124.1 - 7.8 7.3 8.2 1.7 9.5 1.8 2.7 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal Phospholip_B PF04916.13 EKE41125.1 - 3.8e-138 461.4 6.7 4.6e-138 461.1 6.7 1.0 1 0 0 1 1 1 1 Phospholipase B Synaptobrevin PF00957.21 EKE41126.1 - 7.3e-23 80.2 6.7 8.1e-23 80.0 6.7 1.0 1 0 0 1 1 1 1 Synaptobrevin GP41 PF00517.17 EKE41126.1 - 1.2e-05 25.3 2.2 1.3e-05 25.2 2.2 1.0 1 0 0 1 1 1 1 Retroviral envelope protein Orf78 PF06024.12 EKE41126.1 - 0.0016 18.7 0.7 0.0019 18.5 0.7 1.1 1 0 0 1 1 1 1 Orf78 (ac78) Baculo_F PF12259.8 EKE41126.1 - 0.0043 15.6 2.1 0.0048 15.5 2.1 1.0 1 0 0 1 1 1 1 Baculovirus F protein DUF2207 PF09972.9 EKE41126.1 - 0.0064 15.3 0.3 0.0064 15.3 0.3 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF3671 PF12420.8 EKE41126.1 - 0.0071 16.4 1.5 0.0092 16.1 1.5 1.3 1 0 0 1 1 1 1 Protein of unknown function RIFIN PF02009.16 EKE41126.1 - 0.0084 16.0 2.8 0.009 15.9 2.8 1.0 1 0 0 1 1 1 1 Rifin LRRC37AB_C PF14914.6 EKE41126.1 - 0.0093 15.9 1.6 0.0099 15.8 1.6 1.1 1 0 0 1 1 1 1 LRRC37A/B like protein 1 C-terminal domain Collectrin PF16959.5 EKE41126.1 - 0.01 15.6 0.5 0.012 15.4 0.5 1.2 1 0 0 1 1 1 0 Renal amino acid transporter UL45 PF05473.12 EKE41126.1 - 0.012 15.3 0.0 0.012 15.3 0.0 1.0 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like SLATT_5 PF18160.1 EKE41126.1 - 0.016 14.5 0.2 0.02 14.2 0.2 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF4199 PF13858.6 EKE41126.1 - 0.021 15.2 0.4 0.025 15.0 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Shisa PF13908.6 EKE41126.1 - 0.022 15.0 0.3 0.023 14.9 0.3 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF5345 PF17280.2 EKE41126.1 - 0.04 13.9 0.4 0.049 13.6 0.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5345) EMP24_GP25L PF01105.24 EKE41126.1 - 0.04 13.8 1.3 0.053 13.5 1.3 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Pox_EPC_I2-L1 PF12575.8 EKE41126.1 - 0.049 13.9 0.3 0.063 13.5 0.3 1.3 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 YukC PF10140.9 EKE41126.1 - 0.051 12.4 0.8 0.057 12.3 0.8 1.0 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC DotU PF09850.9 EKE41126.1 - 0.2 11.3 0.0 0.23 11.1 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system protein DotU UPF0258 PF06789.12 EKE41126.1 - 0.65 10.1 6.0 0.65 10.1 5.1 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0258) DUF3827 PF12877.7 EKE41126.1 - 2.3 6.5 14.1 2.1 6.6 13.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3827) Sigma_reg_N PF13800.6 EKE41126.1 - 3.3 8.0 9.2 0.7 10.2 5.9 1.6 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF5383 PF17355.2 EKE41126.1 - 6.6 7.1 7.7 12 6.3 7.7 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5383) PH PF00169.29 EKE41127.1 - 1.2e-12 48.2 0.0 2.3e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EKE41127.1 - 0.012 15.9 0.1 0.026 14.8 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 EKE41127.1 - 0.016 15.6 2.1 0.047 14.1 2.1 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain UPF0180 PF03698.13 EKE41127.1 - 0.16 12.2 0.5 20 5.4 0.3 2.8 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0180) GFD1 PF17331.2 EKE41127.1 - 4.3 7.6 7.8 15 6.0 7.8 1.8 1 0 0 1 1 1 0 GFD1 mRNA transport factor Sld5 PF05916.11 EKE41129.1 - 1.7e-21 76.7 2.0 2.9e-21 76.0 0.0 2.1 3 0 0 3 3 3 1 GINS complex protein Acetyltransf_11 PF13720.6 EKE41129.1 - 0.085 13.3 0.1 0.29 11.6 0.1 1.8 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 FNIP PF05725.12 EKE41130.1 - 0.58 10.4 10.6 0.063 13.5 1.3 4.0 3 1 1 4 4 4 0 FNIP Repeat C2 PF00168.30 EKE41131.1 - 1e-18 67.5 0.0 1.2e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 C2 domain Aminotran_1_2 PF00155.21 EKE41132.1 - 6.4e-45 153.9 0.0 6.3e-29 101.3 0.0 2.0 2 0 0 2 2 2 2 Aminotransferase class I and II Endotoxin_N PF03945.14 EKE41133.1 - 0.032 13.9 4.1 0.078 12.7 4.1 1.6 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain CD45 PF12567.8 EKE41133.1 - 0.066 13.2 1.9 0.11 12.4 0.2 2.3 2 0 0 2 2 2 0 Leukocyte receptor CD45 Sec2p PF06428.11 EKE41133.1 - 2 8.4 9.5 1.4 8.9 6.8 2.2 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p TP53IP5 PF15331.6 EKE41133.1 - 2.4 8.3 7.0 4.2 7.4 7.0 1.4 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Spc24 PF08286.11 EKE41133.1 - 4.1 7.7 8.9 1.4 9.2 5.6 2.2 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 Rav1p_C PF12234.8 EKE41134.1 - 8.3e-48 163.2 4.0 8e-46 156.7 3.2 2.7 1 1 0 1 1 1 1 RAVE protein 1 C terminal SecA_PP_bind PF01043.20 EKE41134.1 - 0.00055 20.6 0.1 0.0038 17.9 0.0 2.5 2 0 0 2 2 2 1 SecA preprotein cross-linking domain WD40 PF00400.32 EKE41134.1 - 0.1 13.5 2.1 20 6.3 0.0 5.3 6 0 0 6 6 6 0 WD domain, G-beta repeat TLD PF07534.16 EKE41135.1 - 2e-08 34.5 0.3 3.9e-08 33.6 0.3 1.5 1 0 0 1 1 1 1 TLD Ceramidase_alk PF04734.13 EKE41135.1 - 0.024 13.3 0.2 0.035 12.8 0.2 1.2 1 0 0 1 1 1 0 Neutral/alkaline non-lysosomal ceramidase, N-terminal ALMT PF11744.8 EKE41135.1 - 3.9 6.2 8.1 6.5 5.5 8.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Pkinase PF00069.25 EKE41136.1 - 8.9e-76 254.7 0.2 1.6e-75 253.9 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41136.1 - 1.7e-47 161.9 0.0 2.4e-47 161.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 EKE41136.1 - 5.6e-13 49.1 0.2 1.2e-12 48.0 0.2 1.6 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 EKE41136.1 - 7.5e-05 22.2 0.1 0.00033 20.1 0.0 2.0 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EKE41136.1 - 0.0054 16.1 0.8 0.014 14.8 0.8 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EKE41136.1 - 0.015 15.2 0.1 0.17 11.8 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Cdd1 PF11731.8 EKE41136.1 - 0.041 14.1 0.1 0.15 12.3 0.0 1.9 2 0 0 2 2 2 0 Pathogenicity locus RNA_pol_Rpb1_5 PF04998.17 EKE41136.1 - 0.1 12.0 2.9 0.15 11.5 2.9 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Pkinase_Tyr PF07714.17 EKE41137.1 - 2.3e-32 112.3 0.1 3.5e-32 111.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41137.1 - 5e-25 88.4 0.7 1e-24 87.4 0.7 1.4 1 0 0 1 1 1 1 Protein kinase domain Metallophos PF00149.28 EKE41138.1 - 1.6e-08 35.3 0.5 3.3e-08 34.3 0.5 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase zf-C3HC4_2 PF13923.6 EKE41139.1 - 7.5e-10 38.5 10.3 1.7e-09 37.3 10.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE41139.1 - 1.1e-09 38.5 10.5 1.1e-09 38.5 10.5 2.1 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EKE41139.1 - 1.3e-07 31.8 9.4 2.9e-07 30.7 9.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EKE41139.1 - 1.3e-06 28.2 10.4 3e-06 27.0 10.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EKE41139.1 - 6.4e-06 25.9 7.3 1.3e-05 25.0 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EKE41139.1 - 0.00018 21.4 10.4 0.00039 20.3 10.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 EKE41139.1 - 0.0012 18.6 10.1 0.0019 17.9 6.8 2.8 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EKE41139.1 - 0.0012 18.8 3.9 0.0027 17.7 3.9 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3H2C3 PF17122.5 EKE41139.1 - 0.0014 18.6 11.6 0.0034 17.4 11.6 1.7 1 0 0 1 1 1 1 Zinc-finger CUE PF02845.16 EKE41139.1 - 0.0017 18.0 0.0 0.0033 17.1 0.0 1.4 1 0 0 1 1 1 1 CUE domain zf-RING_UBOX PF13445.6 EKE41139.1 - 0.012 15.7 5.5 0.012 15.7 5.5 2.3 1 1 1 2 2 2 0 RING-type zinc-finger RAG1_imp_bd PF12560.8 EKE41139.1 - 0.052 13.1 1.7 0.095 12.2 1.7 1.3 1 0 0 1 1 1 0 RAG1 importin binding Zn_ribbon_17 PF17120.5 EKE41139.1 - 0.057 13.1 7.7 0.13 11.9 7.7 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PheRS_DBD2 PF18554.1 EKE41139.1 - 0.075 13.0 1.1 0.19 11.8 1.1 1.6 1 0 0 1 1 1 0 PheRS DNA binding domain 2 FANCL_C PF11793.8 EKE41139.1 - 0.22 11.7 10.1 3.8 7.8 10.1 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_4 PF14447.6 EKE41139.1 - 1.6 8.7 9.7 3.6 7.5 9.7 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RhoGEF PF00621.20 EKE41142.1 - 4.4e-14 53.1 6.6 4.4e-14 53.1 6.6 2.6 2 1 0 3 3 3 1 RhoGEF domain ATP-synt_F6 PF05511.11 EKE41142.1 - 1.5 9.3 6.0 1.8 9.0 0.1 2.9 3 0 0 3 3 3 0 Mitochondrial ATP synthase coupling factor 6 DUF2175 PF09943.9 EKE41142.1 - 3.4 8.0 9.8 2.7 8.3 0.1 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) MCPVI PF02993.14 EKE41143.1 - 0.0014 18.5 0.1 0.0016 18.3 0.1 1.1 1 0 0 1 1 1 1 Minor capsid protein VI Gelsolin PF00626.22 EKE41144.1 - 1.8e-48 162.4 26.4 1e-09 38.2 0.0 9.2 10 0 0 10 10 10 7 Gelsolin repeat LRR_8 PF13855.6 EKE41144.1 - 2.8e-20 71.8 22.4 6.3e-07 29.1 7.6 4.6 2 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EKE41144.1 - 1.5e-17 63.4 27.8 5.9e-05 23.4 1.1 6.2 6 0 0 6 6 6 4 Leucine Rich repeats (2 copies) VHP PF02209.19 EKE41144.1 - 6.2e-14 51.8 5.0 3.1e-13 49.6 5.0 2.4 1 0 0 1 1 1 1 Villin headpiece domain LRR_6 PF13516.6 EKE41144.1 - 4.4 7.6 15.3 36 4.8 0.3 6.1 6 0 0 6 6 6 0 Leucine Rich repeat TPR_12 PF13424.6 EKE41145.1 - 0.21 11.9 1.6 0.86 9.9 0.3 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat Ras PF00071.22 EKE41146.1 - 6.4e-45 152.7 0.9 7.9e-45 152.4 0.9 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41146.1 - 3.8e-23 82.0 0.4 7.6e-23 81.0 0.1 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41146.1 - 2.1e-10 40.4 0.1 2.5e-10 40.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE41146.1 - 6.4e-07 29.0 0.0 9.2e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EKE41146.1 - 1.1e-06 28.8 0.0 1.5e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE41146.1 - 9.3e-06 25.3 0.4 0.0026 17.3 0.4 2.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE41146.1 - 0.00027 20.4 0.1 0.00032 20.1 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE41146.1 - 0.013 15.4 0.2 2 8.3 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase FeoB_N PF02421.18 EKE41146.1 - 0.031 13.8 0.1 0.074 12.6 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B PRK PF00485.18 EKE41146.1 - 0.08 12.7 0.5 0.15 11.8 0.1 1.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Propeptide_C1 PF08127.13 EKE41146.1 - 0.12 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C1 propeptide Pro_isomerase PF00160.21 EKE41147.1 - 4.3e-47 160.3 0.1 5.2e-47 160.0 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TLD PF07534.16 EKE41148.1 - 2e-07 31.3 2.5 5.3e-07 29.9 2.5 1.7 1 0 0 1 1 1 1 TLD DUF3552 PF12072.8 EKE41148.1 - 0.0033 16.9 3.7 0.0059 16.1 3.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) Pkinase_Tyr PF07714.17 EKE41150.1 - 2.9e-33 115.2 0.1 3.6e-33 114.9 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41150.1 - 9.5e-31 107.1 0.2 1.3e-30 106.7 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EKE41150.1 - 0.0033 16.8 0.0 0.005 16.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKE41150.1 - 0.056 12.2 0.3 0.098 11.4 0.1 1.4 2 0 0 2 2 2 0 Fungal protein kinase Lipase_3 PF01764.25 EKE41151.1 - 1.5e-05 24.8 0.0 3.2e-05 23.8 0.0 1.5 1 1 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EKE41151.1 - 0.12 11.6 0.1 0.26 10.5 0.0 1.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 ETRAMP PF09716.10 EKE41152.1 - 0.11 12.6 1.8 0.25 11.5 1.8 1.8 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF2116 PF09889.9 EKE41152.1 - 0.23 11.4 3.1 0.38 10.8 0.0 2.7 2 1 1 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Adeno_E3_CR2 PF02439.15 EKE41152.1 - 0.33 10.7 5.7 1.3 8.8 5.7 2.0 1 1 0 1 1 1 0 Adenovirus E3 region protein CR2 Synaptobrevin PF00957.21 EKE41152.1 - 5 7.0 5.3 0.6 9.9 0.5 2.0 2 0 0 2 2 2 0 Synaptobrevin DUF2061 PF09834.9 EKE41152.1 - 5.6 7.6 9.0 23 5.6 1.3 3.3 3 1 0 3 3 3 0 Predicted membrane protein (DUF2061) HSP70 PF00012.20 EKE41153.1 - 3.4e-80 269.9 11.3 3.9e-80 269.7 11.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE41153.1 - 3.7e-05 22.7 0.2 3.7e-05 22.7 0.2 2.2 3 1 0 3 3 3 1 MreB/Mbl protein Raco_middle PF17651.1 EKE41153.1 - 0.00013 21.7 3.8 0.3 10.8 0.0 4.0 4 0 0 4 4 4 2 RACo middle region DUF1376 PF07120.11 EKE41153.1 - 0.031 14.6 0.7 5.1 7.5 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1376) Snapin_Pallidin PF14712.6 EKE41153.1 - 0.054 13.9 1.3 0.22 12.0 1.1 2.1 1 1 0 1 1 1 0 Snapin/Pallidin FtsA PF14450.6 EKE41153.1 - 0.094 13.1 5.7 2.4 8.6 0.8 3.3 3 2 0 3 3 3 0 Cell division protein FtsA Rhamno_transf PF11316.8 EKE41153.1 - 0.21 10.9 0.8 0.43 9.9 0.8 1.4 1 0 0 1 1 1 0 Putative rhamnosyl transferase KxDL PF10241.9 EKE41153.1 - 0.22 11.8 4.2 0.17 12.1 0.9 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein Pkinase PF00069.25 EKE41154.1 - 4e-15 55.9 0.7 4.8e-15 55.6 0.7 1.1 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 EKE41154.1 - 1.5e-12 47.5 0.0 2e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 EKE41154.1 - 2.2e-11 43.6 0.2 2.5e-11 43.4 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EKE41154.1 - 4e-09 36.8 0.0 4.5e-05 23.5 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EKE41154.1 - 1.4e-07 31.1 0.0 3.6e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.11 EKE41154.1 - 6.5e-05 22.7 0.4 7.9e-05 22.4 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) DUF1679 PF07914.11 EKE41154.1 - 0.00057 18.9 0.5 0.041 12.8 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 EKE41154.1 - 0.0014 18.3 0.2 0.033 13.8 0.1 2.1 1 1 1 2 2 2 1 Choline/ethanolamine kinase EcKinase PF02958.20 EKE41154.1 - 0.0085 15.4 0.1 0.011 15.0 0.1 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase FtsX PF02687.21 EKE41156.1 - 2e-10 41.0 28.9 8.6e-08 32.6 10.8 6.1 6 1 1 7 7 7 2 FtsX-like permease family Vma12 PF11712.8 EKE41156.1 - 9.9 6.2 7.7 4.8 7.3 1.0 3.4 3 0 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Flavin_Reduct PF01613.18 EKE41157.1 - 8.5e-05 22.6 0.0 0.0001 22.4 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain UBA PF00627.31 EKE41158.1 - 1.7e-11 43.8 4.5 8e-09 35.2 0.2 3.2 2 1 0 2 2 2 2 UBA/TS-N domain LRR_8 PF13855.6 EKE41158.1 - 0.00025 20.8 3.7 0.00025 20.8 3.7 3.9 5 0 0 5 5 5 1 Leucine rich repeat NTF2 PF02136.20 EKE41158.1 - 0.0018 18.9 1.4 0.0062 17.1 1.4 2.0 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain UBA_4 PF14555.6 EKE41158.1 - 0.0043 16.8 0.2 2.7 7.9 0.0 3.7 3 0 0 3 3 3 1 UBA-like domain LRR_4 PF12799.7 EKE41158.1 - 1.1 9.8 23.4 0.69 10.4 5.5 5.1 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) SAGA-Tad1 PF12767.7 EKE41159.1 - 5.6e-08 32.8 0.0 6.2e-08 32.7 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit Ribosomal_L23 PF00276.20 EKE41160.1 - 3.7e-14 52.8 3.1 3.7e-14 52.8 3.1 2.2 2 1 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 EKE41160.1 - 0.0015 18.7 2.8 0.0015 18.7 2.8 2.1 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain IF-2B PF01008.17 EKE41160.1 - 0.0069 15.6 0.1 0.0071 15.6 0.1 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family zf-RING_2 PF13639.6 EKE41161.1 - 9.2e-10 38.7 8.9 1.8e-09 37.8 8.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKE41161.1 - 2e-08 33.9 6.6 3.8e-08 33.0 6.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EKE41161.1 - 1.4e-07 31.2 6.6 2.4e-07 30.5 6.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EKE41161.1 - 2.9e-07 30.7 7.9 1.1e-06 28.8 7.9 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EKE41161.1 - 1.6e-06 27.9 5.4 3.3e-06 26.9 5.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EKE41161.1 - 0.00011 22.3 3.0 0.00035 20.7 3.1 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EKE41161.1 - 0.00024 21.1 4.0 0.00025 21.0 0.9 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EKE41161.1 - 0.00086 19.3 2.5 0.0083 16.1 2.5 2.3 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EKE41161.1 - 0.00089 19.2 6.8 0.0019 18.1 6.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EKE41161.1 - 0.0014 18.5 7.0 0.0024 17.7 7.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EKE41161.1 - 0.0065 16.3 2.1 0.0065 16.3 2.1 1.7 2 0 0 2 2 1 1 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 EKE41161.1 - 0.011 15.4 10.1 0.023 14.4 5.5 2.5 2 0 0 2 2 2 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EKE41161.1 - 0.024 14.2 8.0 0.051 13.2 8.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Cys_rich_CPXG PF14255.6 EKE41161.1 - 0.029 14.3 5.7 0.35 10.8 1.6 2.7 2 1 0 2 2 2 0 Cysteine-rich CPXCG FANCL_C PF11793.8 EKE41161.1 - 0.072 13.3 8.4 1.5 9.0 8.4 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain TerY_C PF15616.6 EKE41161.1 - 0.11 12.6 2.3 0.19 11.8 2.3 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain TNFR_16_TM PF18422.1 EKE41161.1 - 0.17 11.8 0.1 0.17 11.8 0.1 3.7 4 0 0 4 4 3 0 Tumor necrosis factor receptor member 16 trans-membrane domain zf-RING-like PF08746.11 EKE41161.1 - 0.22 11.9 7.3 0.45 10.9 7.3 1.6 1 0 0 1 1 1 0 RING-like domain Prok-RING_1 PF14446.6 EKE41161.1 - 0.51 10.3 6.8 1.7 8.7 3.4 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.10 EKE41161.1 - 0.77 9.9 3.5 0.43 10.7 0.9 1.9 1 1 1 2 2 2 0 Zinc ribbon domain RINGv PF12906.7 EKE41161.1 - 2.1 8.6 7.2 5.1 7.3 7.2 1.7 1 1 0 1 1 1 0 RING-variant domain C1_1 PF00130.22 EKE41161.1 - 2.7 7.9 7.9 1.6 8.7 5.2 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4209 PF13910.6 EKE41162.1 - 1.3e-16 60.6 0.7 3.7e-13 49.5 0.4 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF4209) Beach PF02138.18 EKE41163.1 - 2.7e-57 194.3 0.5 3.5e-57 193.9 0.5 1.1 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 EKE41163.1 - 0.00055 20.7 8.6 0.073 14.0 0.9 4.1 5 0 0 5 5 5 2 WD domain, G-beta repeat TLD PF07534.16 EKE41164.1 - 8.7e-07 29.2 1.1 1.9e-06 28.2 1.1 1.7 1 0 0 1 1 1 1 TLD Fungal_lectin_2 PF18647.1 EKE41164.1 - 0.0014 19.0 1.7 0.005 17.3 1.7 2.0 1 0 0 1 1 1 1 Alpha-galactosyl-binding fungal lectin CLZ PF16526.5 EKE41164.1 - 0.064 13.6 3.0 0.19 12.1 0.2 2.6 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels XhlA PF10779.9 EKE41164.1 - 0.11 12.7 11.8 0.75 10.0 2.6 2.9 2 0 0 2 2 2 0 Haemolysin XhlA DUF1664 PF07889.12 EKE41164.1 - 0.31 11.1 9.9 0.11 12.6 3.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 EKE41164.1 - 0.78 9.8 6.1 4.5 7.3 6.0 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3496 PF12001.8 EKE41164.1 - 1.3 9.4 9.6 0.16 12.3 4.6 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3496) MtrG PF04210.13 EKE41164.1 - 2 8.3 5.3 0.84 9.5 0.2 2.8 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF4407 PF14362.6 EKE41164.1 - 5.7 6.2 9.1 7.9 5.7 9.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-ZPR1 PF03367.13 EKE41164.1 - 6.8 6.5 8.9 0.51 10.2 1.8 2.6 2 1 0 2 2 2 0 ZPR1 zinc-finger domain CH PF00307.31 EKE41165.1 - 2.2e-07 31.1 13.1 0.00072 19.7 0.0 4.6 4 1 0 4 4 4 2 Calponin homology (CH) domain Pkinase_Tyr PF07714.17 EKE41166.1 - 5.8e-53 179.8 0.3 9.3e-53 179.1 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41166.1 - 7.3e-53 179.6 1.3 1.1e-52 179.0 1.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Ephrin_rec_like PF07699.13 EKE41166.1 - 4.3e-12 45.6 72.8 1.7e-07 30.9 5.8 37.2 14 9 20 36 36 31 12 Putative ephrin-receptor like Pkinase_fungal PF17667.1 EKE41166.1 - 1.3e-07 30.8 0.1 2.2e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKE41166.1 - 0.00036 19.9 0.0 0.00056 19.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKE41166.1 - 0.0011 18.4 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Vpu PF00558.19 EKE41166.1 - 0.072 12.9 4.2 0.23 11.3 4.2 1.8 1 0 0 1 1 1 0 Vpu protein EphA2_TM PF14575.6 EKE41166.1 - 0.12 13.3 0.1 0.62 11.0 0.1 2.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EKE41166.1 - 0.26 11.2 1.5 0.66 9.9 1.5 1.6 1 0 0 1 1 1 0 TMEM154 protein family Sigma_reg_N PF13800.6 EKE41166.1 - 0.26 11.6 4.6 0.69 10.2 4.6 1.7 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Baculo_11_kDa PF06143.11 EKE41166.1 - 1.9 8.1 5.8 5.2 6.7 5.8 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF5385 PF17359.2 EKE41166.1 - 2.6 7.6 9.3 0.23 11.0 3.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5385) RhoGEF PF00621.20 EKE41167.1 - 4.4e-30 105.3 11.9 4.4e-30 105.3 11.9 2.5 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 EKE41167.1 - 0.0026 18.2 1.2 0.0049 17.3 0.2 2.0 2 0 0 2 2 2 1 PH domain DUF4404 PF14357.6 EKE41167.1 - 0.62 10.7 3.0 10 6.8 0.0 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) SAM_4 PF18017.1 EKE41167.1 - 1.2 9.2 3.3 1.7 8.6 0.0 2.7 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) ERM PF00769.19 EKE41168.1 - 5.6e-06 26.3 6.6 7.4e-06 26.0 6.6 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family zf-Di19 PF05605.12 EKE41168.1 - 1.8e-05 24.9 12.0 0.00017 21.8 0.1 3.4 2 1 1 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding MAD PF05557.13 EKE41168.1 - 0.00025 19.6 22.2 0.00034 19.2 22.2 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein zf-WRNIP1_ubi PF18279.1 EKE41168.1 - 0.00038 20.9 5.8 0.43 11.3 0.2 3.4 3 0 0 3 3 3 2 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-C2H2_4 PF13894.6 EKE41168.1 - 0.0013 19.4 8.5 0.098 13.5 0.2 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger V_ATPase_I PF01496.19 EKE41168.1 - 0.021 12.8 14.2 0.026 12.5 14.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HTH_27 PF13463.6 EKE41168.1 - 0.16 12.5 0.6 0.38 11.3 0.2 1.7 2 0 0 2 2 2 0 Winged helix DNA-binding domain zf-H2C2_2 PF13465.6 EKE41168.1 - 1.3 9.6 7.7 5.3 7.6 1.0 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.26 EKE41168.1 - 1.4 9.6 4.0 5.5 7.6 0.1 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type TolA_bind_tri PF16331.5 EKE41168.1 - 1.4 9.1 14.7 4.8 7.3 7.4 2.7 2 1 0 2 2 2 0 TolA binding protein trimerisation ADIP PF11559.8 EKE41168.1 - 3.2 7.8 25.9 0.26 11.4 11.8 3.0 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Zn-C2H2_12 PF18112.1 EKE41168.1 - 4.8 7.7 13.5 0.66 10.5 5.3 3.2 2 1 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain DUF3450 PF11932.8 EKE41168.1 - 9.1 5.5 23.3 0.76 9.0 15.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF4026 PF13218.6 EKE41169.1 - 0.0094 15.0 0.8 0.013 14.5 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4026) Stap_Strp_toxin PF01123.20 EKE41169.1 - 0.038 14.9 2.5 0.078 13.8 1.0 2.2 2 0 0 2 2 2 0 Staphylococcal/Streptococcal toxin, OB-fold domain Glycoprot_B_PH2 PF17417.2 EKE41169.1 - 0.16 12.3 3.4 0.35 11.2 3.4 1.5 1 0 0 1 1 1 0 Herpesvirus Glycoprotein B PH-like domain zf-C3HC4_3 PF13920.6 EKE41170.1 - 8.1e-11 41.6 6.9 1.1e-10 41.1 6.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE41170.1 - 1.4e-07 31.4 4.5 1.4e-07 31.4 4.5 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EKE41170.1 - 3.4e-07 30.1 8.4 7.2e-07 29.1 8.4 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EKE41170.1 - 5.2e-07 29.4 11.4 7.8e-07 28.8 10.4 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE41170.1 - 1.2e-06 28.3 12.5 2.1e-06 27.5 12.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE41170.1 - 4.2e-06 27.0 8.6 4.2e-06 27.0 8.6 1.6 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 EKE41170.1 - 6e-06 26.3 10.0 1.3e-05 25.2 10.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EKE41170.1 - 8.9e-05 22.3 11.1 0.00064 19.5 11.8 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EKE41170.1 - 0.0028 17.5 8.6 0.0098 15.8 6.2 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein TerY_C PF15616.6 EKE41170.1 - 0.029 14.5 4.5 0.053 13.6 4.5 1.5 1 1 0 1 1 1 0 TerY-C metal binding domain zf-Nse PF11789.8 EKE41170.1 - 0.038 13.8 5.0 0.12 12.3 5.0 1.9 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-Di19 PF05605.12 EKE41170.1 - 0.25 11.7 4.7 4.5 7.6 0.2 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding NOB1_Zn_bind PF08772.11 EKE41170.1 - 1.2 9.3 6.9 8.6 6.6 2.6 2.3 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Zn_ribbon_17 PF17120.5 EKE41170.1 - 1.3 8.7 7.1 0.83 9.3 4.8 1.8 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EKE41170.1 - 1.3 8.8 12.8 1.2 8.9 9.3 2.4 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EKE41170.1 - 2.2 8.1 9.6 1 9.1 1.7 2.7 2 1 0 2 2 2 0 RING-like zinc finger RecR PF02132.15 EKE41170.1 - 2.6 7.7 10.9 16 5.1 0.1 2.7 2 1 0 2 2 2 0 RecR protein zf-MIZ PF02891.20 EKE41170.1 - 8.8 6.2 10.9 42 4.0 10.9 2.2 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger Mei5 PF10376.9 EKE41171.1 - 5.8e-10 39.4 7.3 7.2e-10 39.1 7.3 1.1 1 0 0 1 1 1 1 Double-strand recombination repair protein Phage_rep_org_N PF09681.10 EKE41171.1 - 0.033 14.1 0.9 0.059 13.3 0.0 1.8 2 0 0 2 2 2 0 N-terminal phage replisome organiser (Phage_rep_org_N) Mu-like_Pro PF10123.9 EKE41171.1 - 0.037 13.6 2.1 0.24 10.9 0.0 2.1 1 1 1 2 2 2 0 Mu-like prophage I protein DUF5094 PF17015.5 EKE41171.1 - 0.16 12.1 4.8 0.5 10.4 2.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5094) Pkinase PF00069.25 EKE41172.1 - 6.9e-49 166.6 0.1 1.2e-48 165.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41172.1 - 3e-46 157.8 0.0 4.8e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase VSP PF03302.13 EKE41172.1 - 0.00083 18.3 117.8 0.015 14.2 17.9 4.9 1 1 2 3 3 3 3 Giardia variant-specific surface protein Pkinase_fungal PF17667.1 EKE41172.1 - 0.0015 17.4 0.0 0.0025 16.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE41172.1 - 0.012 15.0 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ras PF00071.22 EKE41173.1 - 2.9e-16 59.5 0.1 3.5e-16 59.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EKE41173.1 - 2.3e-07 30.5 0.1 2.9e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EKE41173.1 - 2.5e-07 30.9 0.0 4.8e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EKE41173.1 - 0.043 13.3 0.1 0.1 12.1 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EKE41173.1 - 0.072 13.6 4.4 1.5 9.3 4.4 2.1 1 1 0 1 1 1 0 ABC transporter AAA PF00004.29 EKE41173.1 - 0.079 13.4 0.5 2.2 8.7 0.5 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EKE41173.1 - 0.097 12.8 0.3 1.6 8.8 0.1 2.7 1 1 0 2 2 2 0 50S ribosome-binding GTPase Pkinase PF00069.25 EKE41174.1 - 1.2e-05 24.8 1.7 1.7e-05 24.3 1.7 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41174.1 - 4.7e-05 22.8 0.4 8e-05 22.0 0.4 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase LIM PF00412.22 EKE41175.1 - 1.3e-24 86.2 22.8 7.2e-13 48.6 4.0 3.6 3 1 1 4 4 4 2 LIM domain zinc_ribbon_2 PF13240.6 EKE41175.1 - 7.3e-09 35.1 34.5 0.0026 17.4 0.2 7.1 7 0 0 7 7 7 4 zinc-ribbon domain DZR PF12773.7 EKE41175.1 - 3.5e-07 30.1 33.4 6.1e-06 26.2 1.0 4.9 2 1 0 2 2 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 EKE41175.1 - 1.6e-05 24.1 32.6 0.00019 20.7 6.5 6.9 6 1 0 6 6 6 2 zinc-ribbon domain CDC27 PF09507.10 EKE41175.1 - 0.011 15.2 17.7 0.015 14.8 17.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 YhfH PF14149.6 EKE41175.1 - 0.015 15.3 27.2 0.45 10.5 0.6 6.6 5 1 1 6 6 6 0 YhfH-like protein zinc-ribbons_6 PF07191.12 EKE41175.1 - 0.032 14.2 0.2 0.032 14.2 0.2 4.7 2 1 0 2 2 1 0 zinc-ribbons ORC6 PF05460.13 EKE41175.1 - 0.043 13.1 13.3 0.06 12.6 13.3 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Presenilin PF01080.17 EKE41175.1 - 0.16 10.7 3.6 0.19 10.5 3.6 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EKE41175.1 - 0.21 10.2 2.2 0.26 9.9 2.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Nudix_N_2 PF14803.6 EKE41175.1 - 0.24 11.4 34.2 0.65 10.0 0.1 6.4 5 2 1 6 6 6 0 Nudix N-terminal zf_Rg PF17915.1 EKE41175.1 - 2.2 7.7 16.2 5.9 6.4 0.8 4.1 2 1 1 3 3 3 0 Reverse gyrase zinc finger XPA_N PF01286.18 EKE41175.1 - 2.4 8.3 0.0 2.4 8.3 0.0 5.4 5 1 1 6 6 6 0 XPA protein N-terminal Mitofilin PF09731.9 EKE41175.1 - 2.4 6.9 10.5 3.1 6.5 10.5 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Sec62 PF03839.16 EKE41175.1 - 3.5 7.1 5.3 5.8 6.3 5.3 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Gin PF10764.9 EKE41175.1 - 4.3 7.4 21.3 0.42 10.6 0.2 4.5 3 2 1 4 4 4 0 Inhibitor of sigma-G Gin Menin PF05053.13 EKE41175.1 - 4.6 5.5 7.0 5.8 5.1 7.0 1.2 1 0 0 1 1 1 0 Menin zf_UBZ PF18439.1 EKE41175.1 - 6.6 6.4 32.0 6.4 6.5 0.3 6.6 6 1 1 7 7 6 0 Ubiquitin-Binding Zinc Finger Coilin_N PF15862.5 EKE41175.1 - 9.8 6.0 13.0 13 5.6 10.3 2.0 2 0 0 2 2 2 0 Coilin N-terminus HMG_box PF00505.19 EKE41176.1 - 1.9e-10 41.0 3.1 1.9e-10 41.0 3.1 3.3 3 1 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EKE41176.1 - 3e-10 40.5 3.2 3e-10 40.5 3.2 3.0 2 1 0 3 3 3 1 HMG-box domain Protamine_like PF06382.11 EKE41176.1 - 0.037 14.2 7.8 0.46 10.7 1.0 2.1 1 1 1 2 2 2 0 Protamine and protamine like FAM195 PF14799.6 EKE41176.1 - 1.2 9.6 7.1 2.8 8.3 0.1 2.2 2 0 0 2 2 2 0 FAM195 family DUF5377 PF17347.2 EKE41177.1 - 0.0054 17.1 0.8 0.017 15.5 0.1 1.9 1 1 0 2 2 2 1 Family of unknown function (DUF5377) DUF2207 PF09972.9 EKE41178.1 - 3e-05 23.0 6.7 0.043 12.6 0.8 2.9 2 1 1 3 3 3 2 Predicted membrane protein (DUF2207) Neurensin PF14927.6 EKE41178.1 - 0.0033 17.1 0.3 0.59 9.8 0.0 3.3 3 0 0 3 3 3 1 Neurensin DUF2700 PF10912.8 EKE41178.1 - 0.013 15.5 4.0 0.051 13.6 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2700) Myc_target_1 PF15179.6 EKE41178.1 - 0.039 13.9 0.6 7.1 6.5 0.1 2.4 2 0 0 2 2 2 0 Myc target protein 1 Phage_holin_3_6 PF07332.11 EKE41178.1 - 0.053 13.6 5.3 1.8 8.6 0.1 3.1 3 1 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3034 PF11231.8 EKE41178.1 - 0.17 11.4 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3034) MCM PF00493.23 EKE41180.1 - 2.3e-93 311.4 0.0 4.1e-93 310.6 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EKE41180.1 - 2e-32 111.7 0.6 3.4e-32 110.9 0.6 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EKE41180.1 - 8.1e-21 74.3 0.0 1.8e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EKE41180.1 - 7.4e-09 35.3 0.1 2e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EKE41180.1 - 4.9e-06 26.6 0.1 3.7e-05 23.8 0.0 2.6 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) MCM_N PF14551.6 EKE41180.1 - 1.1e-05 26.0 0.9 3.2e-05 24.5 0.5 2.1 2 0 0 2 2 2 1 MCM N-terminal domain AAA_3 PF07726.11 EKE41180.1 - 4.1e-05 23.4 0.0 0.00012 22.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EKE41180.1 - 0.0036 17.0 0.0 0.047 13.4 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 EKE41180.1 - 0.0065 16.9 0.4 0.087 13.2 0.4 2.5 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase_C PF13335.6 EKE41180.1 - 0.019 15.6 0.0 0.091 13.4 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal AAA PF00004.29 EKE41180.1 - 0.033 14.6 0.0 0.11 12.9 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 EKE41180.1 - 0.15 12.0 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA lid domain Smr PF01713.21 EKE41181.1 - 1.3e-05 25.5 0.1 2.9e-05 24.3 0.1 1.6 1 0 0 1 1 1 1 Smr domain Thg1C PF14413.6 EKE41181.1 - 1.1 9.5 6.8 3.1 8.0 0.6 2.2 2 0 0 2 2 2 0 Thg1 C terminal domain RhoGAP PF00620.27 EKE41182.1 - 5.3e-33 114.0 0.0 1.2e-32 112.9 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 EKE41182.1 - 6.3e-05 23.1 2.7 6.3e-05 23.1 2.7 1.8 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain Rtt106_N PF18215.1 EKE41182.1 - 0.081 12.7 0.3 3.5 7.4 0.1 2.8 2 0 0 2 2 2 0 Histone chaperone Rtt106 N-terminal domain TMF_TATA_bd PF12325.8 EKE41182.1 - 0.47 10.7 4.9 1.1 9.4 4.9 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Pkinase PF00069.25 EKE41183.1 - 7.3e-42 143.5 0.1 1.2e-41 142.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41183.1 - 3.2e-23 82.4 0.0 4.6e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.22 EKE41185.1 - 1.4e-10 40.8 0.6 5.2e-06 26.2 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4358 PF14270.6 EKE41185.1 - 0.017 15.4 2.2 0.19 12.0 0.2 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4358) DUF5449 PF17528.2 EKE41185.1 - 0.022 14.6 1.6 0.023 14.5 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5449) TPR_1 PF00515.28 EKE41186.1 - 3.7e-14 51.8 2.0 5.7e-05 22.8 0.6 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat STI1 PF17830.1 EKE41186.1 - 1.2e-11 44.4 4.4 2.3e-11 43.4 2.9 2.3 2 0 0 2 2 2 1 STI1 domain HipN PF18253.1 EKE41186.1 - 7e-11 41.6 0.0 1.5e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Hsp70-interacting protein N N-terminal domain TPR_2 PF07719.17 EKE41186.1 - 1.2e-10 40.6 1.0 0.055 13.6 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 EKE41186.1 - 3.1e-09 36.6 0.5 4.1e-05 23.7 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKE41186.1 - 1.7e-06 27.6 0.4 0.021 14.5 0.3 2.7 1 1 1 2 2 2 2 TPR repeat TPR_16 PF13432.6 EKE41186.1 - 1.8e-06 28.5 0.0 0.018 15.7 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EKE41186.1 - 2.2e-06 27.4 2.0 0.55 10.6 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EKE41186.1 - 1.2e-05 25.7 0.0 0.038 14.8 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EKE41186.1 - 0.00013 21.3 0.0 0.0003 20.1 0.0 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat ChAPs PF09295.10 EKE41186.1 - 0.027 13.5 0.3 0.044 12.8 0.3 1.4 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) NARP1 PF12569.8 EKE41186.1 - 0.035 13.0 0.2 0.035 13.0 0.2 4.0 1 1 3 4 4 3 0 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 EKE41186.1 - 0.037 14.2 0.0 0.08 13.1 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 EKE41186.1 - 0.11 13.0 0.3 6 7.5 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat OAD_gamma PF04277.13 EKE41186.1 - 4.4 8.0 8.3 1.1e+02 3.5 0.0 2.9 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain IF4E PF01652.18 EKE41187.1 - 3.7e-30 104.8 1.3 4.3e-30 104.6 1.3 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E TFIIB PF00382.19 EKE41189.1 - 2e-25 88.6 0.0 6.9e-13 48.4 0.0 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EKE41189.1 - 2.7e-12 46.9 8.0 2.7e-12 46.9 8.0 2.9 4 0 0 4 4 4 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EKE41189.1 - 7.6e-07 28.6 1.8 2.1e-06 27.1 1.8 1.8 1 0 0 1 1 1 1 TFIIB zinc-binding DUF2318 PF10080.9 EKE41189.1 - 0.001 19.2 0.6 0.0045 17.1 0.5 2.1 2 0 0 2 2 2 1 Predicted membrane protein (DUF2318) A2L_zn_ribbon PF08792.10 EKE41189.1 - 0.0039 16.9 3.2 0.0084 15.8 3.2 1.6 1 0 0 1 1 1 1 A2L zinc ribbon domain Sigma70_r4 PF04545.16 EKE41189.1 - 0.021 14.4 0.5 0.49 10.0 0.2 2.8 2 0 0 2 2 2 0 Sigma-70, region 4 zf-RRN7 PF11781.8 EKE41189.1 - 0.036 13.8 1.3 0.036 13.8 1.3 2.0 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 OrfB_Zn_ribbon PF07282.11 EKE41189.1 - 0.055 13.4 1.1 0.16 11.9 1.1 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Ephrin_rec_like PF07699.13 EKE41189.1 - 0.083 12.7 1.7 0.17 11.6 1.7 1.4 1 0 0 1 1 1 0 Putative ephrin-receptor like LRR_9 PF14580.6 EKE41190.1 - 0.013 15.1 0.7 0.013 15.1 0.7 4.2 4 1 0 5 5 5 0 Leucine-rich repeat RhoGAP PF00620.27 EKE41191.1 - 5.3e-21 75.0 0.0 1.9e-20 73.2 0.0 2.0 1 0 0 1 1 1 1 RhoGAP domain UBX PF00789.20 EKE41192.1 - 6.5e-19 67.9 0.6 2.3e-18 66.2 0.1 2.2 2 0 0 2 2 2 1 UBX domain DUF1682 PF07946.14 EKE41192.1 - 0.0018 17.5 21.4 0.0018 17.5 21.4 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1682) Borrelia_P83 PF05262.11 EKE41192.1 - 0.077 11.5 21.3 0.11 11.0 21.3 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Merozoite_SPAM PF07133.11 EKE41192.1 - 0.092 12.7 29.4 0.18 11.8 29.4 1.5 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) HSP70 PF00012.20 EKE41192.1 - 0.16 10.1 10.3 0.2 9.8 10.3 1.2 1 0 0 1 1 1 0 Hsp70 protein SAE2 PF08573.10 EKE41192.1 - 0.87 10.7 11.1 2.8 9.1 11.1 1.9 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Asp-B-Hydro_N PF05279.11 EKE41192.1 - 1.7 8.7 22.0 2.4 8.2 22.0 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Presenilin PF01080.17 EKE41192.1 - 2.7 6.7 11.8 4 6.1 11.8 1.2 1 0 0 1 1 1 0 Presenilin DUF5401 PF17380.2 EKE41192.1 - 5.6 4.9 32.6 7.7 4.5 32.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) BPL_N PF09825.9 EKE41192.1 - 6 5.8 9.0 13 4.7 9.0 1.6 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal O-antigen_lig PF13425.6 EKE41192.1 - 9.6 4.9 11.4 20 3.8 11.4 1.7 1 0 0 1 1 1 0 O-antigen ligase like membrane protein APG5 PF04106.12 EKE41193.1 - 1.1e-33 116.7 1.0 1.1e-33 116.7 1.0 1.5 2 0 0 2 2 2 1 Autophagy protein Apg5 ABC_tran PF00005.27 EKE41194.1 - 3.2e-37 128.1 0.0 4.7e-17 62.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EKE41194.1 - 1.5e-12 47.4 7.2 1.3e-06 28.0 0.4 3.6 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EKE41194.1 - 1.3e-10 41.6 10.2 0.013 15.3 0.1 4.7 3 2 2 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EKE41194.1 - 7.4e-07 29.7 0.0 0.04 14.3 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain Fer4 PF00037.27 EKE41194.1 - 9.9e-07 28.3 2.9 9.9e-07 28.3 2.9 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_22 PF13401.6 EKE41194.1 - 3.9e-06 27.2 0.3 0.0027 18.0 0.0 2.6 2 1 0 2 2 2 1 AAA domain RLI PF04068.15 EKE41194.1 - 5.6e-06 26.1 4.0 5.6e-06 26.1 4.0 1.8 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA PF00004.29 EKE41194.1 - 6.6e-06 26.6 0.0 0.024 15.0 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EKE41194.1 - 2.4e-05 24.3 0.2 0.0039 17.1 0.0 2.7 2 1 1 3 3 3 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 EKE41194.1 - 7e-05 22.8 0.1 0.092 12.6 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EKE41194.1 - 7e-05 22.5 0.9 0.43 10.4 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EKE41194.1 - 0.00017 21.4 8.7 0.17 11.5 3.2 3.7 2 1 0 3 3 3 2 AAA ATPase domain Fer4_6 PF12837.7 EKE41194.1 - 0.00024 21.0 11.6 0.00038 20.4 2.1 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_10 PF13237.6 EKE41194.1 - 0.00024 21.2 11.6 0.00036 20.6 1.5 2.6 2 0 0 2 2 2 1 4Fe-4S dicluster domain SRP54 PF00448.22 EKE41194.1 - 0.00036 20.2 0.4 0.31 10.6 0.0 2.4 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain Fer4_21 PF14697.6 EKE41194.1 - 0.0004 20.4 11.0 0.0022 18.1 11.3 2.0 1 1 1 2 2 2 1 4Fe-4S dicluster domain AAA_18 PF13238.6 EKE41194.1 - 0.00061 20.3 1.2 2.2 8.8 0.0 3.4 4 0 0 4 4 3 2 AAA domain RNA_helicase PF00910.22 EKE41194.1 - 0.00069 20.0 0.0 2 8.8 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 EKE41194.1 - 0.0011 19.3 0.1 0.83 9.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EKE41194.1 - 0.0022 17.9 0.7 0.53 10.2 0.0 2.6 3 0 0 3 3 2 1 NACHT domain TsaE PF02367.17 EKE41194.1 - 0.0025 17.8 0.0 0.14 12.2 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EKE41194.1 - 0.0026 17.5 0.1 0.4 10.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EKE41194.1 - 0.0047 17.0 2.0 1.1 9.3 0.0 3.4 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EKE41194.1 - 0.0056 16.2 0.1 0.09 12.3 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 EKE41194.1 - 0.0071 16.4 0.3 1 9.3 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) SbcCD_C PF13558.6 EKE41194.1 - 0.009 16.2 0.0 3.3 8.0 0.0 2.9 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 EKE41194.1 - 0.0097 15.6 0.2 2.5 7.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain Septin PF00735.18 EKE41194.1 - 0.016 14.5 0.1 0.86 8.8 0.0 2.4 2 0 0 2 2 2 0 Septin NB-ARC PF00931.22 EKE41194.1 - 0.018 14.2 0.1 0.95 8.6 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Fer4_9 PF13187.6 EKE41194.1 - 0.029 14.5 9.8 0.068 13.3 9.6 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain VirE PF05272.11 EKE41194.1 - 0.029 14.1 0.1 3.9 7.2 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E Fer4_7 PF12838.7 EKE41194.1 - 0.032 14.8 11.1 0.032 14.8 2.1 2.2 1 1 2 3 3 3 0 4Fe-4S dicluster domain ATPase PF06745.13 EKE41194.1 - 0.033 13.5 0.2 0.095 12.0 0.2 1.8 1 0 0 1 1 1 0 KaiC G-alpha PF00503.20 EKE41194.1 - 0.054 12.6 0.2 0.82 8.8 0.0 2.5 1 1 1 2 2 2 0 G-protein alpha subunit Fer4_16 PF13484.6 EKE41194.1 - 0.078 13.9 0.8 0.078 13.9 0.8 3.5 3 0 0 3 3 2 0 4Fe-4S double cluster binding domain AAA_25 PF13481.6 EKE41194.1 - 0.091 12.3 0.0 2.9 7.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EKE41194.1 - 0.13 12.5 0.3 0.97 9.7 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 EKE41194.1 - 0.16 12.1 4.6 1 9.5 0.0 3.1 4 0 0 4 4 2 0 AAA domain AAA_13 PF13166.6 EKE41194.1 - 0.16 10.6 0.0 0.16 10.6 0.0 3.4 3 1 1 4 4 2 0 AAA domain MMR_HSR1 PF01926.23 EKE41194.1 - 0.18 11.9 2.6 4.1 7.5 0.1 2.8 2 2 0 2 2 2 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EKE41194.1 - 0.66 9.2 0.0 0.66 9.2 0.0 3.4 4 0 0 4 4 3 0 Zeta toxin Thymidylate_kin PF02223.17 EKE41194.1 - 1.6 8.4 6.4 9.9 5.8 0.0 3.7 4 0 0 4 4 3 0 Thymidylate kinase SLR1-BP PF07333.12 EKE41194.1 - 3.6 8.1 8.2 8.4 6.9 8.2 1.6 1 0 0 1 1 1 0 S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP) DUF1682 PF07946.14 EKE41194.1 - 6 6.0 9.3 12 5.0 9.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Fer4_2 PF12797.7 EKE41194.1 - 6.7 7.0 10.9 0.18 11.9 1.5 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Peptidase_C1 PF00112.23 EKE41195.1 - 6e-14 52.7 0.1 1.1e-13 51.7 0.0 1.5 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE41195.1 - 4.1e-05 23.9 2.4 6e-05 23.4 2.4 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) CBM_4_9 PF02018.17 EKE41196.1 - 1.1e-06 28.9 1.2 2.5e-06 27.8 1.2 1.7 1 0 0 1 1 1 1 Carbohydrate binding domain Helicase_IV_N PF12462.8 EKE41197.1 - 0.026 14.5 0.2 0.11 12.4 0.0 2.1 2 1 0 2 2 2 0 DNA helicase IV / RNA helicase N terminal DUF2203 PF09969.9 EKE41197.1 - 0.071 13.8 0.6 3.9 8.2 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF3231 PF11553.8 EKE41197.1 - 0.14 11.8 3.0 0.21 11.2 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3231) CttA_N PF18244.1 EKE41198.1 - 0.021 15.3 1.7 0.077 13.4 0.5 2.6 2 0 0 2 2 2 0 Cellulose-binding protein CttA N-terminal domain BsuBI_PstI_RE_N PF17728.1 EKE41198.1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease HTH domain Metallophos PF00149.28 EKE41199.1 - 3.2e-39 135.6 0.0 4.5e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Acetyltransf_9 PF13527.7 EKE41200.1 - 1.2e-13 51.2 0.0 1.5e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EKE41200.1 - 8.6e-12 45.3 0.0 1.2e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EKE41200.1 - 1.8e-09 37.9 0.0 2.5e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EKE41200.1 - 1.3e-07 31.6 0.2 2.1e-07 30.9 0.2 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EKE41200.1 - 0.0011 18.9 0.1 0.0023 17.9 0.1 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_16 PF05301.11 EKE41200.1 - 0.022 14.6 0.1 0.027 14.2 0.1 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 MOZ_SAS PF01853.18 EKE41200.1 - 0.054 13.1 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 MOZ/SAS family DUF3726 PF12525.8 EKE41200.1 - 0.13 12.4 0.0 4.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3726) DUF4600 PF15372.6 EKE41201.1 - 9.3 6.7 6.7 12 6.3 2.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) DNA_pol_B PF00136.21 EKE41203.1 - 1.6e-92 310.6 6.6 2.7e-71 240.7 5.0 2.3 1 1 1 2 2 2 2 DNA polymerase family B DUF1744 PF08490.12 EKE41203.1 - 0.00067 18.3 0.6 0.0019 16.8 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1744) Tmemb_55A PF09788.9 EKE41203.1 - 0.009 15.1 0.3 0.016 14.3 0.3 1.3 1 0 0 1 1 1 1 Transmembrane protein 55A zf-C2H2_6 PF13912.6 EKE41203.1 - 1.1 9.4 7.8 5.2 7.2 2.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger UPF0179 PF03684.13 EKE41203.1 - 1.7 8.5 8.8 0.5 10.2 0.5 3.3 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0179) HSP33 PF01430.19 EKE41203.1 - 1.7 8.0 5.1 4.3 6.7 5.1 1.6 1 0 0 1 1 1 0 Hsp33 protein zf-ribbon_3 PF13248.6 EKE41203.1 - 2.5 7.6 5.5 38 3.9 0.2 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Cytochrom_c3_2 PF14537.6 EKE41203.1 - 3.6 8.1 5.1 10 6.7 5.1 1.7 1 0 0 1 1 1 0 Cytochrome c3 UQ_con PF00179.26 EKE41205.1 - 2.7e-15 56.2 0.0 6.8e-15 54.9 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Peptidase_S64 PF08192.11 EKE41205.1 - 0.065 11.7 17.9 0.099 11.1 17.9 1.2 1 0 0 1 1 1 0 Peptidase family S64 Consortin_C PF15281.6 EKE41205.1 - 0.095 12.7 0.3 0.095 12.7 0.3 2.2 2 1 2 4 4 4 0 Consortin C-terminus DUF3797 PF12677.7 EKE41205.1 - 0.21 11.5 0.2 0.21 11.5 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) LMBR1 PF04791.16 EKE41205.1 - 0.28 10.0 12.7 0.37 9.6 12.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Renin_r PF07850.14 EKE41205.1 - 2.2 8.9 9.2 17 6.1 9.2 2.5 1 1 0 1 1 1 0 Renin receptor-like protein FAR1 PF03101.15 EKE41207.1 - 4.9e-07 30.3 3.3 8.4e-07 29.6 3.3 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain AFT PF08731.11 EKE41207.1 - 2.4e-05 24.7 4.4 3.9e-05 24.0 2.8 2.1 2 1 0 2 2 2 1 Transcription factor AFT Arrestin_C PF02752.22 EKE41208.1 - 0.0096 16.4 1.5 0.029 14.8 0.8 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EKE41208.1 - 0.022 14.8 0.0 0.053 13.6 0.0 1.6 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain Antibiotic_NAT PF02522.14 EKE41210.1 - 0.23 11.2 0.0 0.32 10.8 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside 3-N-acetyltransferase RGP PF03214.13 EKE41212.1 - 0.0082 15.3 0.1 0.015 14.5 0.1 1.3 1 0 0 1 1 1 1 Reversibly glycosylated polypeptide TTSSLRR PF12468.8 EKE41212.1 - 0.033 14.4 0.8 0.12 12.6 0.4 2.1 2 0 0 2 2 2 0 Type III secretion system leucine rich repeat protein Ank_5 PF13857.6 EKE41213.1 - 6.8e-09 35.8 0.0 1.3e-06 28.5 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKE41213.1 - 6.8e-06 26.6 0.3 0.044 14.4 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKE41213.1 - 0.0029 18.0 0.0 2.7 8.9 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat Pkinase PF00069.25 EKE41214.1 - 5.2e-68 229.3 0.0 7.7e-68 228.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41214.1 - 1.2e-48 165.7 0.0 1.7e-48 165.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EKE41214.1 - 9.2e-09 35.5 1.9 2.7e-08 34.0 0.3 2.5 2 0 0 2 2 2 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 EKE41214.1 - 8.3e-06 24.8 0.0 1.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKE41214.1 - 1.2e-05 24.8 0.0 2.1e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EKE41214.1 - 0.034 13.2 0.1 0.085 11.9 0.0 1.7 2 0 0 2 2 2 0 Seadornavirus VP7 DUF1356 PF07092.12 EKE41214.1 - 0.035 13.4 0.0 0.064 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) DUF4099 PF13351.6 EKE41214.1 - 0.1 12.9 0.2 0.3 11.4 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4099) APH PF01636.23 EKE41214.1 - 0.13 12.2 0.0 2.6 7.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF4885 PF16226.5 EKE41216.1 - 0.0017 17.5 0.3 0.002 17.2 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4885) Ras PF00071.22 EKE41218.1 - 1.8e-54 183.7 0.4 2.2e-54 183.4 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41218.1 - 2.8e-31 108.2 0.2 5.9e-31 107.2 0.1 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41218.1 - 7e-12 45.1 0.0 8.9e-12 44.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE41218.1 - 7.5e-05 22.4 0.5 0.01 15.4 0.5 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE41218.1 - 0.0019 17.6 0.0 0.0024 17.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE41218.1 - 0.0032 17.5 0.0 0.0056 16.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE41218.1 - 0.0053 16.2 0.1 0.011 15.2 0.0 1.6 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE41218.1 - 0.011 15.7 0.1 0.033 14.1 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase Polo_box_2 PF18531.1 EKE41218.1 - 0.11 12.7 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Polo box domain Ras PF00071.22 EKE41219.1 - 2.7e-54 183.2 0.0 3.1e-54 182.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41219.1 - 2.2e-22 79.5 0.0 3e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41219.1 - 1.1e-06 28.2 0.0 1.5e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE41219.1 - 0.082 12.2 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RRM_1 PF00076.22 EKE41220.1 - 2.8e-07 30.2 0.2 5e-07 29.5 0.1 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EKE41220.1 - 0.00011 22.2 3.9 0.00018 21.4 3.9 1.4 1 0 0 1 1 1 1 Zinc knuckle DAPDH_C PF16654.5 EKE41220.1 - 0.011 15.6 0.2 0.016 15.1 0.2 1.2 1 0 0 1 1 1 0 Diaminopimelic acid dehydrogenase C-terminal domain DUF3978 PF13123.6 EKE41220.1 - 0.016 15.0 0.5 0.022 14.5 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3978) RRM_3 PF08777.11 EKE41220.1 - 0.039 14.0 0.1 0.057 13.5 0.1 1.3 1 0 0 1 1 1 0 RNA binding motif RRM_5 PF13893.6 EKE41220.1 - 0.13 11.9 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF936 PF06075.12 EKE41220.1 - 8.8 5.1 23.7 11 4.7 23.7 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) eIF-5_eIF-2B PF01873.17 EKE41221.1 - 9.6e-39 131.9 0.8 2.3e-38 130.7 0.8 1.6 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EKE41221.1 - 3.3e-09 36.8 0.5 3.3e-09 36.8 0.5 2.3 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Rota_NS53 PF00981.17 EKE41221.1 - 0.01 14.7 0.0 0.018 14.0 0.0 1.3 1 0 0 1 1 1 0 Rotavirus RNA-binding Protein 53 (NS53) zinc_ribbon_12 PF11331.8 EKE41221.1 - 0.2 11.5 1.6 0.48 10.3 1.6 1.6 1 0 0 1 1 1 0 Probable zinc-ribbon domain YceD PF02620.17 EKE41221.1 - 3.2 7.9 10.9 0.13 12.4 2.4 2.4 2 1 0 2 2 2 0 Large ribosomal RNA subunit accumulation protein YceD PAP2_C PF14360.6 EKE41222.1 - 3e-08 34.1 12.5 3e-08 34.1 12.5 3.1 3 1 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EKE41222.1 - 3.9e-06 26.7 1.3 3.9e-06 26.7 1.3 2.2 2 1 0 3 3 3 1 PAP2 superfamily Myb_DNA-binding PF00249.31 EKE41223.1 - 1.2e-27 95.8 4.1 9.8e-15 54.5 0.5 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE41223.1 - 1.4e-24 86.1 1.0 1.3e-14 54.1 0.1 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EKE41223.1 - 2.5e-05 24.1 0.5 0.24 11.3 0.0 2.2 2 0 0 2 2 2 2 Myb DNA-binding like SLIDE PF09111.10 EKE41223.1 - 3.7e-05 23.7 0.2 0.26 11.3 0.1 2.2 1 1 1 2 2 2 2 SLIDE Rap1_C PF11626.8 EKE41223.1 - 0.022 14.8 1.3 0.52 10.4 0.2 2.1 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain PCI PF01399.27 EKE41224.1 - 0.0003 21.3 0.4 0.00089 19.7 0.1 1.9 2 0 0 2 2 2 1 PCI domain DUF5492 PF17596.2 EKE41224.1 - 0.015 15.6 0.4 0.068 13.5 0.2 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5492) CLP1_P PF16575.5 EKE41225.1 - 4e-20 72.4 0.1 6.3e-20 71.8 0.1 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop MeaB PF03308.16 EKE41225.1 - 7.5e-07 28.4 0.0 1e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB KAP_NTPase PF07693.14 EKE41225.1 - 0.013 14.7 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain IIGP PF05049.13 EKE41225.1 - 0.014 14.5 0.2 0.026 13.6 0.2 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) DUF87 PF01935.17 EKE41225.1 - 0.018 15.1 0.0 0.039 14.0 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain ABC_tran PF00005.27 EKE41225.1 - 0.019 15.5 0.1 0.035 14.6 0.1 1.4 1 0 0 1 1 1 0 ABC transporter ATP_bind_1 PF03029.17 EKE41225.1 - 0.036 13.9 0.1 0.063 13.0 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EKE41225.1 - 0.073 13.2 0.1 0.24 11.5 0.1 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 EKE41225.1 - 0.081 13.3 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 EKE41225.1 - 0.094 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.6 EKE41225.1 - 0.12 12.4 0.0 0.38 10.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EKE41225.1 - 0.15 12.0 0.1 0.49 10.3 0.1 1.8 1 0 0 1 1 1 0 RsgA GTPase A_thal_3526 PF09713.10 EKE41226.1 - 2.6e-11 43.6 1.0 5.7e-11 42.5 1.0 1.6 1 0 0 1 1 1 1 Plant protein 1589 of unknown function (A_thal_3526) NRIP1_repr_2 PF15688.5 EKE41226.1 - 0.058 13.3 3.2 0.11 12.4 3.2 1.3 1 0 0 1 1 1 0 Nuclear receptor-interacting protein 1 repression 2 zf-UBR PF02207.20 EKE41227.1 - 9.1e-17 61.0 17.1 9.1e-17 61.0 17.1 4.1 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) DUF1247 PF06851.11 EKE41227.1 - 0.045 13.7 2.2 3.2 7.7 0.1 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1247) Adaptin_N PF01602.20 EKE41228.1 - 4.9e-77 259.7 18.5 5.5e-77 259.5 18.5 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EKE41228.1 - 5e-07 29.9 7.4 0.00014 21.9 0.2 3.3 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.7 EKE41228.1 - 1.9e-05 24.0 2.2 0.022 14.0 0.1 2.6 1 1 1 2 2 2 2 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 EKE41228.1 - 2e-05 24.3 0.6 0.0063 16.1 0.0 3.1 2 1 1 3 3 3 1 CLASP N terminal HEAT PF02985.22 EKE41228.1 - 2.3e-05 24.3 3.0 0.66 10.4 0.0 5.1 5 0 0 5 5 5 2 HEAT repeat RTP1_C1 PF10363.9 EKE41228.1 - 2.6e-05 24.4 3.0 0.012 15.7 0.2 4.3 3 2 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 EKE41228.1 - 0.0002 21.7 0.0 1.2 9.6 0.0 3.0 2 0 0 2 2 2 2 HEAT repeats DNA_alkylation PF08713.11 EKE41228.1 - 0.00079 19.2 0.0 0.72 9.5 0.0 3.6 2 2 0 3 3 3 1 DNA alkylation repair enzyme Vac14_Fab1_bd PF12755.7 EKE41228.1 - 0.0018 18.8 0.4 8.3 7.1 0.0 4.3 2 2 3 5 5 5 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EKE41228.1 - 1.7 9.2 6.2 56 4.4 0.3 4.0 2 1 1 3 3 3 0 HEAT-like repeat Arf PF00025.21 EKE41229.1 - 5.9e-47 159.4 0.1 6.5e-47 159.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE41229.1 - 1.3e-09 37.8 0.6 3.6e-09 36.3 0.6 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EKE41229.1 - 7.2e-09 35.4 0.1 8.6e-09 35.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41229.1 - 2e-07 31.3 0.0 2.8e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EKE41229.1 - 1.6e-05 24.4 0.5 3.2e-05 23.4 0.5 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE41229.1 - 2.9e-05 24.0 0.1 0.002 18.1 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 EKE41229.1 - 0.00031 20.0 1.0 0.00031 20.0 1.0 2.0 1 1 1 2 2 2 1 G-protein alpha subunit cobW PF02492.19 EKE41229.1 - 0.0027 17.3 0.8 0.23 11.0 0.1 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 EKE41229.1 - 0.011 15.2 0.1 0.024 14.2 0.0 1.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 EKE41229.1 - 0.13 12.8 0.3 0.2 12.2 0.3 1.5 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EKE41229.1 - 0.13 12.3 0.4 1 9.5 0.0 2.0 1 1 1 2 2 2 0 50S ribosome-binding GTPase Pkinase PF00069.25 EKE41230.1 - 2.3e-65 220.6 8.6 2.3e-65 220.6 8.6 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41230.1 - 2.7e-34 118.7 4.1 3.6e-34 118.2 4.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EKE41230.1 - 1.1e-05 25.0 1.4 1.8e-05 24.2 1.4 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EKE41230.1 - 0.00068 18.5 2.6 0.0012 17.7 2.6 1.5 1 1 0 1 1 1 1 Fungal protein kinase FHA PF00498.26 EKE41230.1 - 0.0059 16.9 0.6 0.029 14.7 0.3 2.4 2 0 0 2 2 2 1 FHA domain VWA PF00092.28 EKE41231.1 - 1.5e-12 48.2 0.0 7.4e-11 42.6 0.0 2.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EKE41231.1 - 3e-08 34.3 0.0 8e-08 32.9 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain MHB PF16525.5 EKE41231.1 - 0.026 14.8 1.4 7.9 6.8 0.1 2.5 2 0 0 2 2 2 0 Haemophore, haem-binding Med25_VWA PF11265.8 EKE41231.1 - 0.026 14.3 0.0 0.06 13.2 0.0 1.7 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A NifU_N PF01592.16 EKE41231.1 - 0.05 13.7 0.1 0.1 12.7 0.1 1.4 1 0 0 1 1 1 0 NifU-like N terminal domain DUF272 PF03312.15 EKE41231.1 - 0.27 11.5 0.2 0.27 11.5 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF272) DUF3006 PF11213.8 EKE41231.1 - 0.45 10.8 4.9 0.26 11.5 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3006) FH2 PF02181.23 EKE41232.1 - 8e-13 48.3 16.6 8e-13 48.3 16.6 2.9 2 1 0 2 2 2 1 Formin Homology 2 Domain DUF3361 PF11841.8 EKE41232.1 - 9.3e-06 25.7 4.1 4e-05 23.6 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3361) Gal11_ABD1 PF18535.1 EKE41232.1 - 0.1 12.7 1.8 0.58 10.3 0.0 3.1 3 0 0 3 3 3 0 Gal11 activator-binding domain (ABD1) Lebercilin PF15619.6 EKE41232.1 - 0.14 11.8 26.5 0.45 10.2 0.1 3.1 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DiSB-ORF2_chro PF16506.5 EKE41232.1 - 0.22 11.6 0.8 3.1 7.9 0.1 3.0 3 0 0 3 3 3 0 Putative virion glycoprotein of insect viruses TSKS PF15358.6 EKE41232.1 - 0.25 9.7 7.6 0.39 9.0 7.6 1.2 1 0 0 1 1 1 0 Testis-specific serine kinase substrate DUF3450 PF11932.8 EKE41232.1 - 0.29 10.4 13.4 0.12 11.6 10.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Atg14 PF10186.9 EKE41232.1 - 0.35 9.9 11.0 0.74 8.8 11.0 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 KxDL PF10241.9 EKE41232.1 - 0.38 11.1 14.0 0.94 9.8 5.2 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein Chordopox_L2 PF05803.12 EKE41232.1 - 9.7 6.1 7.8 16 5.4 0.2 3.4 2 1 1 3 3 3 0 Chordopoxvirus L2 protein CinA PF02464.17 EKE41233.1 - 9.6e-47 158.4 0.2 1.2e-46 158.2 0.2 1.0 1 0 0 1 1 1 1 Competence-damaged protein FtsA PF14450.6 EKE41233.1 - 0.0087 16.5 0.2 0.013 15.9 0.2 1.2 1 0 0 1 1 1 1 Cell division protein FtsA PolC_DP2 PF03833.13 EKE41233.1 - 0.035 12.0 0.1 0.042 11.7 0.1 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 PTCB-BRCT PF12738.7 EKE41234.1 - 4.8e-18 64.9 0.0 6e-18 64.5 0.0 1.1 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EKE41234.1 - 4.2e-12 46.3 0.0 4.9e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EKE41234.1 - 2e-07 31.3 0.0 2.5e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 EKE41234.1 - 0.01 15.9 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EKE41234.1 - 0.046 14.0 0.0 0.051 13.9 0.0 1.1 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain DNA_alkylation PF08713.11 EKE41235.1 - 7.2e-24 84.7 0.0 9.8e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 DNA alkylation repair enzyme HMG_box PF00505.19 EKE41236.1 - 6.8e-14 52.0 1.7 1e-13 51.4 1.6 1.4 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EKE41236.1 - 4.7e-07 30.3 2.4 6.9e-07 29.8 2.4 1.3 1 0 0 1 1 1 1 HMG-box domain LRR_4 PF12799.7 EKE41237.1 - 7.5e-48 159.7 76.4 1e-07 32.1 1.6 11.9 10 2 2 12 12 12 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE41237.1 - 7.7e-40 134.5 62.4 2.7e-10 39.8 2.9 9.8 5 3 6 11 11 11 9 Leucine rich repeat PP2C PF00481.21 EKE41237.1 - 3.1e-16 59.8 0.0 4.9e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_9 PF14580.6 EKE41237.1 - 1.7e-09 37.4 38.4 0.013 15.0 1.5 6.3 2 1 4 7 7 7 6 Leucine-rich repeat LRR_6 PF13516.6 EKE41237.1 - 2.3e-08 33.4 50.1 1 9.6 0.2 13.1 13 0 0 13 13 13 6 Leucine Rich repeat LRR_1 PF00560.33 EKE41237.1 - 0.00012 22.2 55.4 4.8 8.1 0.2 16.1 15 3 1 16 16 16 2 Leucine Rich Repeat Suppressor_P21 PF11479.8 EKE41237.1 - 2.5 8.3 6.0 3.1 8.1 1.9 3.3 3 0 0 3 3 3 0 RNA silencing suppressor P21 C-terminal domain RNase_HII PF01351.18 EKE41240.1 - 2e-43 148.6 0.0 2.4e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII Zn_ribbon_17 PF17120.5 EKE41240.1 - 0.01 15.5 0.0 0.024 14.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Ret2_MD PF18528.1 EKE41240.1 - 0.088 13.2 0.1 0.3 11.5 0.0 1.8 2 0 0 2 2 2 0 RNA editing 3' terminal uridylyl transferase 2 middle domain Spc7 PF08317.11 EKE41241.1 - 0.00027 19.9 24.4 0.00027 19.9 24.4 5.3 1 1 4 5 5 5 4 Spc7 kinetochore protein bZIP_1 PF00170.21 EKE41241.1 - 0.0029 17.7 5.5 0.0029 17.7 5.5 10.6 7 3 4 11 11 11 4 bZIP transcription factor ZapB PF06005.12 EKE41241.1 - 0.018 15.5 7.7 0.018 15.5 7.7 10.0 3 1 3 6 6 6 0 Cell division protein ZapB Med31 PF05669.12 EKE41242.1 - 8.2e-33 112.3 10.7 1e-32 112.0 10.7 1.1 1 0 0 1 1 1 1 SOH1 Gemini_AL1 PF00799.20 EKE41245.1 - 0.051 14.0 2.8 0.06 13.7 1.0 2.1 2 0 0 2 2 2 0 Geminivirus Rep catalytic domain PP2C_C PF07830.13 EKE41245.1 - 0.12 12.9 3.9 5.4 7.5 0.4 3.4 3 0 0 3 3 3 0 Protein serine/threonine phosphatase 2C, C-terminal domain Gemini_AL1 PF00799.20 EKE41246.1 - 0.028 14.8 1.7 0.038 14.4 0.4 2.0 2 0 0 2 2 2 0 Geminivirus Rep catalytic domain Sec23_trunk PF04811.15 EKE41248.1 - 1.6e-34 119.6 0.1 2.5e-34 118.9 0.1 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 EKE41248.1 - 3.9e-12 46.0 1.6 9.4e-12 44.8 1.6 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 EKE41248.1 - 3.6e-11 42.8 0.0 7.9e-11 41.7 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EKE41248.1 - 1.3e-10 41.9 0.0 4.6e-10 40.1 0.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EKE41248.1 - 0.00085 19.2 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Lipase_3 PF01764.25 EKE41249.1 - 8.5e-23 80.8 0.0 2.1e-22 79.5 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EKE41249.1 - 0.033 13.5 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PGAP1 PF07819.13 EKE41249.1 - 0.046 13.4 1.8 0.082 12.6 0.0 2.1 2 1 0 2 2 2 0 PGAP1-like protein Abhydrolase_5 PF12695.7 EKE41249.1 - 0.067 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family PUF PF00806.19 EKE41250.1 - 5e-07 29.1 5.6 0.019 14.6 0.1 5.0 4 0 0 4 4 4 3 Pumilio-family RNA binding repeat CPL PF08144.11 EKE41250.1 - 1.4e-06 28.7 10.8 5.3e-05 23.6 0.4 4.8 3 2 0 3 3 3 2 CPL (NUC119) domain Porin_3 PF01459.22 EKE41251.1 - 6.6e-09 35.6 0.1 1.1e-08 34.9 0.1 1.3 1 1 0 1 1 1 1 Eukaryotic porin BRCT_2 PF16589.5 EKE41252.1 - 1.6e-07 31.6 0.5 0.0025 18.2 0.0 3.4 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EKE41252.1 - 2.2e-06 27.9 1.4 0.092 13.1 0.1 3.5 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain PQQ_3 PF13570.6 EKE41252.1 - 0.012 16.1 0.0 5.6 7.6 0.1 3.9 4 0 0 4 4 4 0 PQQ-like domain WD40 PF00400.32 EKE41252.1 - 0.021 15.7 0.3 24 6.0 0.0 3.3 3 0 0 3 3 3 0 WD domain, G-beta repeat RTT107_BRCT_5 PF16770.5 EKE41252.1 - 0.042 13.7 0.1 10 6.1 0.1 2.9 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain DUF1189 PF06691.11 EKE41252.1 - 0.065 12.8 7.0 0.6 9.6 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1189) PBP1_TM PF14812.6 EKE41252.1 - 2.2 8.7 9.5 0.46 10.9 2.9 2.5 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pkinase PF00069.25 EKE41253.1 - 9.5e-68 228.4 0.1 1.4e-67 227.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41253.1 - 3.5e-33 115.0 0.1 4.5e-33 114.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE41253.1 - 2.1e-15 57.1 1.5 2.6e-15 56.8 0.4 1.8 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EKE41253.1 - 2.5e-06 27.8 1.9 5.4e-05 23.6 1.9 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EKE41253.1 - 8.9e-06 25.9 0.2 1.8e-05 25.0 0.2 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Kinase-like PF14531.6 EKE41253.1 - 4.4e-05 22.9 0.1 0.0036 16.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like PH_3 PF14593.6 EKE41253.1 - 6.3e-05 23.0 0.1 0.00014 21.9 0.1 1.6 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 EKE41253.1 - 0.0009 18.1 0.0 0.0026 16.6 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase PH_9 PF15410.6 EKE41253.1 - 0.0088 16.4 0.6 0.044 14.2 0.1 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain FTA2 PF13095.6 EKE41253.1 - 0.032 13.9 0.6 1.9 8.1 0.2 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 HSP20 PF00011.21 EKE41254.1 - 4.9e-18 65.2 0.0 6.2e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EKE41254.1 - 8.2e-10 38.1 0.0 1.2e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA FKBP26_C PF18046.1 EKE41254.1 - 0.028 14.5 0.1 4.6 7.4 0.0 2.2 2 0 0 2 2 2 0 FKBP26_C-terminal Pro_isomerase PF00160.21 EKE41255.1 - 3.2e-52 177.0 0.3 3.5e-52 176.8 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 EKE41255.1 - 0.043 13.9 0.0 0.063 13.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Pkinase PF00069.25 EKE41256.1 - 1.9e-103 345.5 1.5 8.9e-56 189.2 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41256.1 - 8.7e-65 218.6 1.2 2.3e-35 122.2 0.0 2.4 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE41256.1 - 4.6e-11 42.1 0.1 3e-06 26.3 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase Kinase-like PF14531.6 EKE41256.1 - 1.7e-06 27.6 0.0 0.027 13.8 0.0 3.0 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 EKE41256.1 - 0.15 11.9 0.1 12 5.7 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Nicastrin PF05450.15 EKE41258.1 - 7.3e-07 28.9 0.4 1.3e-06 28.0 0.0 1.6 2 0 0 2 2 2 1 Nicastrin Peptidase_M28 PF04389.17 EKE41258.1 - 2.3e-05 24.2 0.0 4.2e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 Ncstrn_small PF18266.1 EKE41258.1 - 0.00052 20.1 0.4 0.007 16.4 0.4 2.3 1 1 0 1 1 1 1 Nicastrin small lobe ABC2_membrane_3 PF12698.7 EKE41258.1 - 0.031 13.4 0.1 0.031 13.4 0.1 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein PCI PF01399.27 EKE41259.1 - 0.0025 18.3 2.7 0.033 14.7 0.2 2.8 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 EKE41259.1 - 0.13 12.4 2.4 1.1 9.6 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat MarR_2 PF12802.7 EKE41259.1 - 0.21 11.5 0.0 0.41 10.6 0.0 1.4 1 0 0 1 1 1 0 MarR family Clat_adaptor_s PF01217.20 EKE41260.1 - 5.3e-38 130.1 4.3 6.5e-38 129.9 4.3 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AP-5_subunit_s1 PF15001.6 EKE41260.1 - 3.1e-05 24.0 0.5 4.9e-05 23.4 0.1 1.6 2 0 0 2 2 2 1 AP-5 complex subunit sigma-1 MFS_1 PF07690.16 EKE41261.1 - 1.2e-11 44.1 35.7 6.5e-11 41.7 29.5 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1878 PF08963.10 EKE41261.1 - 0.071 13.6 0.1 0.18 12.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1878) DNA_primase_S PF01896.19 EKE41262.1 - 1.2e-46 158.9 0.1 2.3e-46 158.0 0.1 1.4 1 0 0 1 1 1 1 DNA primase small subunit Adaptin_N PF01602.20 EKE41264.1 - 6.8e-54 183.3 16.9 6.8e-54 183.3 16.9 1.9 1 1 1 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EKE41264.1 - 1.2e-41 141.7 0.1 4.1e-41 139.9 0.1 2.0 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EKE41264.1 - 2.5e-40 137.6 0.7 7.6e-40 136.1 0.2 2.1 1 1 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 EKE41264.1 - 1.3e-06 28.6 0.0 6.2e-05 23.3 0.0 3.1 2 1 0 2 2 2 1 HEAT repeats Cnd1 PF12717.7 EKE41264.1 - 8e-06 26.0 0.2 8e-06 26.0 0.2 3.8 3 3 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EKE41264.1 - 0.00015 21.7 0.0 0.0085 16.3 0.0 3.2 2 0 0 2 2 2 1 HEAT repeat RPAP3_C PF13877.6 EKE41264.1 - 0.00029 21.3 0.2 1.4 9.6 0.0 4.1 3 0 0 3 3 3 1 Potential Monad-binding region of RPAP3 DNA_alkylation PF08713.11 EKE41264.1 - 0.009 15.7 0.0 0.029 14.1 0.0 1.8 2 0 0 2 2 2 1 DNA alkylation repair enzyme DUF2332 PF10094.9 EKE41264.1 - 0.058 12.8 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2332) MOR2-PAG1_C PF14225.6 EKE41264.1 - 0.1 12.4 2.7 0.21 11.4 0.2 2.7 3 0 0 3 3 3 0 Cell morphogenesis C-terminal T6SS-SciN PF12790.7 EKE41264.1 - 0.11 12.2 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 UPF0061 PF02696.14 EKE41264.1 - 0.31 9.8 2.1 0.54 9.0 2.1 1.4 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family FliL PF03748.14 EKE41264.1 - 1.4 9.5 5.9 3.4 8.3 3.1 3.2 2 0 0 2 2 2 0 Flagellar basal body-associated protein FliL RNA_pol_Rpb6 PF01192.22 EKE41265.1 - 1.2e-13 50.7 0.0 2.1e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 UQ_con PF00179.26 EKE41266.1 - 4.9e-52 175.3 0.0 5.5e-52 175.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKE41266.1 - 0.01 15.5 0.0 0.011 15.4 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 EKE41266.1 - 0.082 13.2 0.0 0.092 13.0 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 EKE41266.1 - 0.084 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 UEV domain dCache_1 PF02743.18 EKE41266.1 - 0.18 11.6 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Cache domain RasGEF PF00617.19 EKE41267.1 - 1.8e-18 67.4 0.3 4.8e-18 66.0 0.3 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE41267.1 - 1.7e-05 25.0 4.0 0.0045 17.2 4.0 3.0 1 1 0 1 1 1 1 RasGEF N-terminal motif LisH_TPL PF17814.1 EKE41267.1 - 0.014 15.1 0.2 0.034 13.8 0.2 1.6 1 0 0 1 1 1 0 LisH-like dimerisation domain Stap_Strp_toxin PF01123.20 EKE41267.1 - 0.077 13.8 1.2 1.3 9.9 0.3 3.0 2 0 0 2 2 2 0 Staphylococcal/Streptococcal toxin, OB-fold domain AMP-binding PF00501.28 EKE41268.1 - 1.7e-22 79.6 0.1 1.7e-22 79.6 0.1 2.1 2 1 0 2 2 2 1 AMP-binding enzyme Glyco_hydro_6 PF01341.17 EKE41268.1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 6 HTH_OrfB_IS605 PF12323.8 EKE41268.1 - 0.039 13.4 0.9 0.82 9.2 0.3 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain DUF1125 PF06563.11 EKE41268.1 - 0.048 13.6 0.1 0.14 12.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1125) DUF2992 PF11208.8 EKE41268.1 - 3.8 7.8 22.4 9.3 6.5 22.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) DUF2098 PF09871.9 EKE41268.1 - 4.1 7.8 11.1 15 6.0 11.1 2.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) ABC_membrane PF00664.23 EKE41269.1 - 2e-47 162.1 16.0 2.7e-47 161.7 16.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EKE41269.1 - 8.1e-14 52.3 0.1 1.5e-13 51.4 0.1 1.5 1 0 0 1 1 1 1 ABC transporter Zeta_toxin PF06414.12 EKE41269.1 - 0.00017 20.9 0.0 0.00029 20.2 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Rad17 PF03215.15 EKE41269.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 EKE41269.1 - 0.021 14.7 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 EKE41269.1 - 0.021 14.5 0.1 0.048 13.4 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EKE41269.1 - 0.022 15.1 0.1 0.043 14.2 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EKE41269.1 - 0.023 14.2 0.0 0.069 12.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 EKE41269.1 - 0.055 13.2 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 EKE41269.1 - 0.079 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_22 PF13401.6 EKE41269.1 - 0.099 12.9 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain SLATT_1 PF18181.1 EKE41269.1 - 0.12 12.3 0.5 7.6 6.5 0.2 2.5 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 AAA_25 PF13481.6 EKE41269.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain UPF0542 PF15086.6 EKE41269.1 - 0.13 12.2 0.2 0.32 11.0 0.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 ABC_membrane PF00664.23 EKE41270.1 - 0.18 11.4 0.0 0.22 11.2 0.0 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region UBA PF00627.31 EKE41271.1 - 2.1e-22 78.6 0.7 2.4e-12 46.5 0.1 2.6 3 0 0 3 3 3 2 UBA/TS-N domain ubiquitin PF00240.23 EKE41271.1 - 1.3e-11 44.0 0.4 2.9e-11 42.9 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin family XPC-binding PF09280.11 EKE41271.1 - 3.1e-07 30.0 0.4 8e-07 28.7 0.4 1.7 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.8 EKE41271.1 - 0.00016 21.4 0.4 0.00036 20.3 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 EKE41271.1 - 0.004 16.9 0.0 0.075 12.9 0.0 2.6 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain FeoA PF04023.14 EKE41271.1 - 0.093 13.0 0.0 8.2 6.8 0.0 2.4 2 0 0 2 2 2 0 FeoA domain DPBB_1 PF03330.18 EKE41272.1 - 0.013 15.7 0.7 16 5.8 0.2 3.6 3 1 0 3 3 3 0 Lytic transglycolase VCBS PF13517.6 EKE41273.1 - 3e-22 79.0 7.1 5.1e-13 49.4 0.1 4.9 2 1 3 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 EKE41273.1 - 0.0016 17.8 0.1 0.12 11.7 0.0 3.5 2 1 2 4 4 4 1 Insecticide toxin TcdB middle/N-terminal region FG-GAP PF01839.23 EKE41273.1 - 0.0074 16.4 6.4 12 6.1 0.2 4.6 4 0 0 4 4 4 2 FG-GAP repeat Ribosomal_L36e PF01158.18 EKE41273.1 - 0.034 14.4 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L36e DUF2439 PF10382.9 EKE41273.1 - 0.046 14.1 0.9 7.5 7.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2439) LapA_dom PF06305.11 EKE41273.1 - 0.23 11.3 1.1 1.6 8.6 0.4 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain CKS PF01111.19 EKE41274.1 - 7.1e-35 119.1 1.0 7.8e-35 119.0 1.0 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit GPR_Gpa2_C PF11970.8 EKE41275.1 - 4.7e-07 29.8 5.0 4.7e-07 29.8 5.0 3.7 3 2 0 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.21 EKE41275.1 - 0.23 10.8 25.5 0.39 10.0 24.8 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) SHP PF03579.13 EKE41275.1 - 8.8 6.4 13.7 0.39 10.7 6.1 2.6 2 0 0 2 2 2 0 Small hydrophobic protein zf-AN1 PF01428.16 EKE41276.1 - 2.4e-07 30.8 36.8 7.9e-06 25.9 9.9 4.0 4 0 0 4 4 4 2 AN1-like Zinc finger TUG-UBL1 PF11470.8 EKE41276.1 - 0.0017 18.5 0.5 1.7 9.0 0.0 2.5 2 0 0 2 2 2 2 TUG ubiquitin-like domain IBR PF01485.21 EKE41276.1 - 6.6 7.0 29.1 6.1 7.1 14.1 2.9 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Tic22 PF04278.12 EKE41277.1 - 0.03 13.7 0.1 0.039 13.3 0.1 1.1 1 0 0 1 1 1 0 Tic22-like family Arm PF00514.23 EKE41278.1 - 2e-12 46.7 0.1 0.0025 17.8 0.0 4.7 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EKE41278.1 - 0.00014 21.8 1.8 0.79 10.1 0.0 4.5 4 0 0 4 4 4 1 HEAT repeat RICTOR_V PF14668.6 EKE41278.1 - 0.00049 20.3 2.5 0.54 10.5 0.1 2.8 2 0 0 2 2 2 2 Rapamycin-insensitive companion of mTOR, domain 5 IBB PF01749.20 EKE41278.1 - 0.00098 19.5 0.5 0.0021 18.5 0.5 1.5 1 0 0 1 1 1 1 Importin beta binding domain HEAT_2 PF13646.6 EKE41278.1 - 0.037 14.4 0.0 8.6 6.8 0.0 2.7 2 1 1 3 3 3 0 HEAT repeats Orf78 PF06024.12 EKE41279.1 - 0.081 13.2 0.6 0.11 12.8 0.6 1.3 1 1 0 1 1 1 0 Orf78 (ac78) PrgI PF12666.7 EKE41279.1 - 0.084 13.6 0.1 0.11 13.2 0.1 1.3 1 0 0 1 1 1 0 PrgI family protein Synaptobrevin PF00957.21 EKE41279.1 - 2.9 7.8 14.4 1.3 8.8 0.6 3.0 1 1 2 3 3 3 0 Synaptobrevin ENTH PF01417.20 EKE41280.1 - 3.6e-27 94.9 0.0 8.6e-27 93.7 0.0 1.7 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EKE41280.1 - 9.8e-05 21.5 0.2 0.00015 20.9 0.2 1.3 1 0 0 1 1 1 1 ANTH domain cwf21 PF08312.12 EKE41280.1 - 0.11 12.7 2.9 1.4 9.1 0.3 2.4 2 0 0 2 2 2 0 cwf21 domain WD40 PF00400.32 EKE41281.1 - 0.013 16.3 8.6 0.22 12.4 0.0 4.9 6 0 0 6 6 6 0 WD domain, G-beta repeat Pkinase_Tyr PF07714.17 EKE41282.1 - 3.2e-53 180.7 0.0 6e-53 179.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41282.1 - 3.4e-45 154.5 0.0 5.3e-45 153.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HSP70 PF00012.20 EKE41284.1 - 5.7e-05 21.5 0.1 6.3e-05 21.4 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF4478 PF14793.6 EKE41284.1 - 0.12 12.2 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases Baculo_11_kDa PF06143.11 EKE41285.1 - 1.6 8.4 4.8 19 4.9 3.3 2.4 2 0 0 2 2 2 0 Baculovirus 11 kDa family Chromo PF00385.24 EKE41287.1 - 3.2e-07 30.2 0.2 0.0019 18.1 0.0 3.4 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain LRR_5 PF13306.6 EKE41288.1 - 1.5e-40 138.2 14.0 1.8e-40 137.9 14.0 1.1 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE41288.1 - 5.5e-10 38.9 0.0 0.0067 16.2 0.0 3.2 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EKE41288.1 - 0.011 16.1 0.9 4.7 7.8 0.1 3.2 1 1 0 2 2 2 0 Leucine Rich repeats (2 copies) zf-Tim10_DDP PF02953.15 EKE41288.1 - 0.19 11.4 15.7 2.2 8.0 2.3 4.7 2 1 3 5 5 5 0 Tim10/DDP family zinc finger APC_r PF05923.12 EKE41288.1 - 1.2 8.9 5.8 13 5.6 0.1 2.6 2 0 0 2 2 2 0 APC repeat Pkinase PF00069.25 EKE41289.1 - 3e-26 92.4 0.1 8.5e-26 90.9 0.1 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41289.1 - 7.8e-13 48.3 0.1 2.8e-12 46.5 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE41289.1 - 1e-11 45.2 1.7 1e-11 45.2 1.7 2.0 2 0 0 2 2 2 1 PH domain PH_3 PF14593.6 EKE41289.1 - 2.1e-06 27.8 1.5 2.1e-06 27.8 1.5 1.8 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EKE41289.1 - 4.4e-06 26.9 0.9 1.1e-05 25.6 0.9 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EKE41289.1 - 1.4e-05 25.4 6.4 6.4e-05 23.3 3.1 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_15 PF17339.2 EKE41289.1 - 0.13 12.2 3.0 0.23 11.3 0.4 2.3 2 0 0 2 2 2 0 PH domain Actin PF00022.19 EKE41291.1 - 2.2e-96 323.0 0.0 1e-95 320.8 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EKE41291.1 - 0.0013 17.6 0.2 0.019 13.8 0.2 2.2 1 1 0 1 1 1 1 MreB/Mbl protein LRR_8 PF13855.6 EKE41293.1 - 0.00036 20.2 8.8 0.029 14.1 2.7 3.3 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EKE41293.1 - 0.01 16.2 15.7 0.19 12.2 0.1 3.6 1 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EKE41293.1 - 0.025 14.6 0.0 0.025 14.6 0.0 4.0 5 0 0 5 5 5 0 Leucine Rich repeat LRR_9 PF14580.6 EKE41293.1 - 0.12 11.8 2.7 1.7 8.1 2.8 2.1 1 1 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 EKE41293.1 - 0.53 11.0 9.8 30 5.7 0.0 4.9 4 1 0 4 4 4 0 Leucine Rich Repeat Ras PF00071.22 EKE41294.1 - 4.7e-51 172.6 0.0 5.4e-51 172.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41294.1 - 1e-25 90.3 0.0 1.6e-25 89.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41294.1 - 4.7e-12 45.7 0.0 6.5e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE41294.1 - 1.9e-05 24.2 0.0 2.3e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 EKE41294.1 - 0.052 13.1 0.0 0.089 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region HTH_34 PF13601.6 EKE41294.1 - 0.061 13.5 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain MMR_HSR1 PF01926.23 EKE41294.1 - 0.068 13.3 0.0 0.11 12.6 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase TniB PF05621.11 EKE41294.1 - 0.079 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 EKE41294.1 - 0.14 11.9 0.3 1.6 8.5 0.3 2.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RhoGAP PF00620.27 EKE41295.1 - 5.1e-21 75.1 1.3 9e-21 74.3 0.2 2.0 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 EKE41295.1 - 0.013 16.0 0.0 0.034 14.6 0.0 1.7 1 0 0 1 1 1 0 PH domain SNARE PF05739.19 EKE41296.1 - 0.00054 19.9 1.4 0.00054 19.9 1.4 1.8 2 0 0 2 2 2 1 SNARE domain RIFIN PF02009.16 EKE41296.1 - 0.0037 17.2 3.3 0.0041 17.1 3.3 1.0 1 0 0 1 1 1 1 Rifin Ran-binding PF05508.11 EKE41296.1 - 0.0055 15.7 4.7 0.0063 15.6 4.7 1.0 1 0 0 1 1 1 1 RanGTP-binding protein DUF1664 PF07889.12 EKE41296.1 - 0.012 15.6 4.9 0.018 15.1 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Shisa PF13908.6 EKE41296.1 - 0.023 15.0 1.9 0.023 15.0 1.9 1.9 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator LMBR1 PF04791.16 EKE41296.1 - 0.036 13.0 0.5 0.04 12.8 0.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF16 PF01519.16 EKE41296.1 - 0.056 13.9 3.2 0.078 13.5 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 MCU PF04678.13 EKE41296.1 - 0.096 12.8 0.2 0.12 12.4 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter APC_15aa PF05972.11 EKE41296.1 - 0.12 12.7 2.9 0.14 12.5 0.1 2.2 2 0 0 2 2 2 0 APC 15 residue motif Amnionless PF14828.6 EKE41296.1 - 0.12 11.2 1.5 0.13 11.0 1.5 1.1 1 0 0 1 1 1 0 Amnionless TMPIT PF07851.13 EKE41296.1 - 0.22 10.7 1.6 0.24 10.6 1.6 1.2 1 0 0 1 1 1 0 TMPIT-like protein Med7 PF05983.11 EKE41296.1 - 0.39 10.8 4.2 0.11 12.6 1.4 1.5 2 0 0 2 2 2 0 MED7 protein Synaptobrevin PF00957.21 EKE41296.1 - 0.48 10.2 7.9 0.98 9.2 7.9 1.7 1 1 0 1 1 1 0 Synaptobrevin Orf78 PF06024.12 EKE41296.1 - 2.6 8.4 8.4 13 6.2 8.4 2.0 1 1 0 1 1 1 0 Orf78 (ac78) DUF1043 PF06295.12 EKE41296.1 - 8.1 6.5 9.0 4.8 7.2 1.9 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1043) DUF3677 PF12432.8 EKE41297.1 - 0.026 14.8 0.4 0.059 13.7 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3677) DUF996 PF06195.13 EKE41297.1 - 0.13 12.5 15.8 4.4 7.6 15.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF996) Shisa PF13908.6 EKE41297.1 - 0.59 10.4 0.1 0.59 10.4 0.1 1.9 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Peptidase_U4 PF03419.13 EKE41297.1 - 0.95 8.7 16.6 0.37 10.0 10.9 2.0 1 1 1 2 2 2 0 Sporulation factor SpoIIGA DUF2663 PF10864.8 EKE41297.1 - 2.9 8.3 10.9 8.1 6.9 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2663) CrgA PF06781.12 EKE41297.1 - 3.5 7.8 10.5 1.1 9.4 0.7 2.2 1 1 1 2 2 2 0 Cell division protein CrgA Presenilin PF01080.17 EKE41297.1 - 4.3 6.0 14.1 7.3 5.2 0.1 2.2 2 1 0 2 2 2 0 Presenilin MgtE PF01769.16 EKE41297.1 - 4.9 7.6 12.8 1.6 9.1 5.4 2.1 1 1 1 2 2 2 0 Divalent cation transporter SPC12 PF06645.13 EKE41297.1 - 6 7.0 14.1 0.62 10.2 5.3 2.5 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Lipase_3 PF01764.25 EKE41298.1 - 2.9e-18 66.1 0.0 5.7e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EKE41298.1 - 0.0074 15.6 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF676 PF05057.14 EKE41298.1 - 0.076 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) RHD3 PF05879.12 EKE41299.1 - 2.8e-150 501.9 12.6 3.6e-150 501.5 12.6 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 EKE41299.1 - 5.8e-06 26.4 0.0 1.7e-05 24.9 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EKE41299.1 - 0.0016 18.7 0.1 0.0046 17.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 EKE41299.1 - 0.0026 17.9 1.6 0.0045 17.1 0.0 2.4 2 1 0 2 2 2 1 Dynamin family CCDC84 PF14968.6 EKE41299.1 - 0.23 11.1 4.4 0.23 11.0 3.4 1.4 1 1 0 1 1 1 0 Coiled coil protein 84 DUF2004 PF09406.10 EKE41299.1 - 4.6 7.6 7.7 26 5.2 0.3 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2004) GNAT_acetyltr_2 PF13718.6 EKE41300.1 - 2.2e-87 292.2 1.5 1.5e-85 286.2 0.0 2.6 2 0 0 2 2 2 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 EKE41300.1 - 2.4e-60 203.4 0.0 2.4e-60 203.4 0.0 2.5 4 0 0 4 4 4 1 Helicase tRNA_bind_2 PF13725.6 EKE41300.1 - 6.4e-38 130.8 8.0 2e-37 129.2 8.0 1.9 1 1 0 1 1 1 1 Possible tRNA binding domain DUF1726 PF08351.11 EKE41300.1 - 2.5e-31 107.5 1.6 1e-30 105.5 0.1 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 EKE41300.1 - 0.0013 18.5 0.1 0.055 13.2 0.0 3.0 2 1 1 3 3 3 1 AAA domain DEAD PF00270.29 EKE41300.1 - 0.015 15.1 0.1 0.037 13.8 0.1 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_19 PF13245.6 EKE41300.1 - 0.032 14.5 0.0 0.12 12.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain Acetyltransf_7 PF13508.7 EKE41300.1 - 0.07 13.6 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CSRNP_N PF16019.5 EKE41300.1 - 0.34 10.8 2.4 0.82 9.6 2.4 1.6 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus VirE3 PF06661.11 EKE41301.1 - 0.1 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 VirE3 Flavodoxin_4 PF12682.7 EKE41301.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin TFIIA PF03153.13 EKE41302.1 - 4.2e-09 36.9 8.7 8.7e-06 26.0 0.2 2.1 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Metallophos PF00149.28 EKE41303.1 - 3.8e-12 47.1 0.7 6.8e-12 46.3 0.7 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF373 PF04123.13 EKE41304.1 - 0.0017 17.9 2.6 0.0018 17.8 2.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF373) DUF4577 PF15145.6 EKE41304.1 - 0.15 12.1 0.3 0.15 12.1 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) PRT_C PF08372.10 EKE41305.1 - 0.0036 17.1 0.1 0.0036 17.1 0.1 1.6 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal DEAD PF00270.29 EKE41307.1 - 1e-19 71.0 0.0 6.2e-19 68.4 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE41307.1 - 2.2e-18 66.6 0.0 2.5e-17 63.2 0.0 3.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EKE41307.1 - 1.7e-13 51.1 5.1 1.7e-13 51.1 5.1 4.2 3 1 0 3 3 3 1 RecQ zinc-binding ResIII PF04851.15 EKE41307.1 - 5.1e-09 36.4 0.0 5.1e-09 36.4 0.0 5.4 3 2 1 5 5 5 1 Type III restriction enzyme, res subunit HRDC PF00570.23 EKE41307.1 - 5.4e-05 23.1 2.6 0.00013 21.8 0.5 3.0 2 1 0 2 2 2 1 HRDC domain TetR_C_27 PF17935.1 EKE41307.1 - 0.14 12.2 0.7 6.8 6.8 0.6 2.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Thioredoxin PF00085.20 EKE41309.1 - 6.9e-13 48.5 0.0 1.1e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EKE41309.1 - 0.0024 18.3 1.1 0.005 17.3 1.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 EKE41309.1 - 0.0093 15.8 0.0 0.019 14.8 0.0 1.6 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 EKE41309.1 - 0.024 15.0 0.8 0.059 13.7 0.3 2.1 2 1 0 2 2 2 0 Thioredoxin-like Thioredoxin_7 PF13899.6 EKE41309.1 - 0.027 14.6 0.0 0.048 13.8 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like AhpC-TSA PF00578.21 EKE41309.1 - 0.035 14.0 0.2 0.09 12.7 0.1 1.6 1 1 0 1 1 1 0 AhpC/TSA family Glutaredoxin PF00462.24 EKE41309.1 - 0.056 13.7 0.1 0.25 11.6 0.1 2.0 2 0 0 2 2 2 0 Glutaredoxin D5_N PF08706.11 EKE41309.1 - 0.06 13.6 0.2 0.12 12.7 0.1 1.5 2 0 0 2 2 2 0 D5 N terminal like Thioredoxin_4 PF13462.6 EKE41309.1 - 0.14 12.3 1.3 0.29 11.3 0.5 1.9 1 1 1 2 2 2 0 Thioredoxin NADPH_Ox PF08414.10 EKE41310.1 - 0.0032 17.8 1.2 0.0051 17.1 0.9 1.6 1 1 0 1 1 1 1 Respiratory burst NADPH oxidase DUF4795 PF16043.5 EKE41310.1 - 0.0045 16.6 15.4 0.0066 16.1 15.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) DUF948 PF06103.11 EKE41310.1 - 0.015 15.6 2.8 0.015 15.6 2.8 2.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) GDPD PF03009.17 EKE41310.1 - 0.044 13.5 5.8 0.052 13.3 5.8 1.1 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Nod1 PF17114.5 EKE41310.1 - 0.068 13.3 4.2 0.041 14.1 2.4 1.7 1 1 1 2 2 2 0 Gef2-related medial cortical node protein Nod1 DUF3810 PF12725.7 EKE41310.1 - 0.63 9.3 8.5 0.048 13.0 0.8 2.4 1 1 1 3 3 3 0 Protein of unknown function (DUF3810) DUF2935 PF11155.8 EKE41310.1 - 0.71 10.2 7.1 0.24 11.7 3.8 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) Cas6b_C PF17262.2 EKE41310.1 - 1.1 9.3 7.8 3.4 7.8 1.3 2.3 1 1 1 2 2 2 0 Cas6b C-terminal domain DUF4570 PF15134.6 EKE41310.1 - 1.4 9.0 7.8 0.19 11.7 3.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) Tup_N PF08581.10 EKE41310.1 - 2.4 8.5 10.9 0.19 12.0 4.0 2.4 1 1 0 2 2 2 0 Tup N-terminal CorA PF01544.18 EKE41310.1 - 3.5 6.9 11.2 6.5 6.0 11.2 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein MRP-S23 PF10484.9 EKE41310.1 - 4.8 7.5 10.2 0.84 9.9 2.1 2.1 1 1 1 2 2 2 0 Mitochondrial ribosomal protein S23 Muted PF14942.6 EKE41310.1 - 5.7 7.3 17.6 1.6 9.1 10.1 2.2 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein YtxH PF12732.7 EKE41310.1 - 6.1 7.4 7.6 4.2e+02 1.6 7.6 2.8 1 1 0 1 1 1 0 YtxH-like protein RtcB PF01139.17 EKE41311.1 - 3.8e-147 490.8 0.5 4.4e-147 490.6 0.5 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB ArgoMid PF16487.5 EKE41311.1 - 0.084 13.1 0.5 9.7 6.5 0.1 2.7 1 1 1 2 2 2 0 Mid domain of argonaute UDPG_MGDP_dh_C PF03720.15 EKE41311.1 - 0.15 12.5 0.1 0.34 11.3 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_binding_9 PF13454.6 EKE41311.1 - 0.16 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Vps16_N PF04841.13 EKE41312.1 - 0.00029 19.7 3.7 0.00067 18.5 0.1 2.4 2 1 1 3 3 3 2 Vps16, N-terminal region Lgl_C PF08596.10 EKE41312.1 - 0.0061 15.3 6.7 0.039 12.7 3.1 2.9 1 1 2 3 3 3 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 EKE41313.1 - 0.012 15.9 0.0 33 4.9 0.0 4.6 5 1 0 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain DCB PF16213.5 EKE41314.1 - 0.015 15.0 5.0 0.026 14.2 5.0 1.4 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 Myb_DNA-binding PF00249.31 EKE41315.1 - 6e-22 77.6 4.0 3.4e-10 39.9 0.5 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE41315.1 - 1.2e-21 76.7 4.1 2e-13 50.4 0.7 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain SAM_KSR1 PF13543.6 EKE41315.1 - 0.019 15.1 0.0 0.047 13.8 0.0 1.5 1 1 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 SANT_DAMP1_like PF16282.5 EKE41315.1 - 0.12 12.6 0.2 0.41 10.9 0.1 2.0 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_4 PF13837.6 EKE41315.1 - 0.26 11.7 8.1 9.5 6.7 0.7 3.8 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain FTCD_C PF04961.12 EKE41315.1 - 0.54 10.0 2.2 0.83 9.4 2.2 1.3 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase zf-C2H2_jaz PF12171.8 EKE41316.1 - 7.5e-06 26.1 0.1 1.4e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EKE41316.1 - 0.00014 22.2 1.1 0.00023 21.4 1.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EKE41316.1 - 0.001 19.4 0.6 0.002 18.5 0.6 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EKE41316.1 - 0.0045 17.7 0.3 0.0089 16.8 0.3 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-BED PF02892.15 EKE41316.1 - 0.027 14.5 0.2 0.053 13.5 0.2 1.5 1 0 0 1 1 1 0 BED zinc finger zf-C2H2_2 PF12756.7 EKE41316.1 - 0.028 14.8 0.2 0.066 13.5 0.1 1.7 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.12 EKE41316.1 - 0.055 13.6 0.0 0.09 12.9 0.0 1.4 1 0 0 1 1 1 0 DBF zinc finger UNC-79 PF14776.6 EKE41316.1 - 0.35 9.6 2.3 0.44 9.3 2.3 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 CENP-U PF13097.6 EKE41317.1 - 0.0064 16.5 1.7 0.011 15.7 1.7 1.3 1 0 0 1 1 1 1 CENP-A nucleosome associated complex (NAC) subunit DUF2018 PF09442.10 EKE41317.1 - 0.052 14.5 1.8 0.12 13.4 1.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2018) DUF4988 PF16378.5 EKE41317.1 - 0.49 10.0 4.3 1.1 8.8 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function CdvA PF18822.1 EKE41317.1 - 0.75 9.6 9.1 0.2 11.5 2.9 2.2 2 0 0 2 2 2 0 CdvA-like coiled-coil domain RNase_PH_C PF03725.15 EKE41318.1 - 1.5e-12 47.4 0.1 2.5e-12 46.6 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 RNase_PH PF01138.21 EKE41318.1 - 2.6e-09 37.7 0.0 4.8e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Pkinase_Tyr PF07714.17 EKE41319.1 - 4.2e-53 180.3 0.2 8.4e-53 179.3 0.1 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41319.1 - 1e-46 159.5 0.2 1.8e-46 158.7 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EKE41319.1 - 0.00046 19.6 0.0 0.00083 18.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EKE41319.1 - 0.001 18.6 0.1 0.002 17.7 0.1 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL EGF_Tenascin PF18720.1 EKE41319.1 - 0.013 15.5 9.4 0.013 15.5 9.4 3.3 4 0 0 4 4 4 0 Tenascin EGF domain APH PF01636.23 EKE41319.1 - 0.081 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family ABC1 PF03109.16 EKE41319.1 - 0.12 12.5 0.0 1.8 8.7 0.0 2.5 1 1 1 2 2 2 0 ABC1 family RIO1 PF01163.22 EKE41319.1 - 6.1 6.4 9.8 1.9 8.1 0.7 2.8 2 1 1 3 3 3 0 RIO1 family TAFII28 PF04719.14 EKE41320.1 - 5.6e-09 36.0 0.0 9e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 hTAFII28-like protein conserved region CBFD_NFYB_HMF PF00808.23 EKE41320.1 - 0.054 13.8 0.1 0.094 13.0 0.1 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EKE41320.1 - 0.082 13.3 0.2 0.12 12.7 0.2 1.5 1 1 0 1 1 1 0 Core histone H2A/H2B/H3/H4 DUF3854 PF12965.7 EKE41320.1 - 0.11 12.5 0.2 0.19 11.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) S-AdoMet_synt_C PF02773.16 EKE41321.1 - 0.0077 16.2 0.0 0.021 14.8 0.0 1.7 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain SR-25 PF10500.9 EKE41322.1 - 0.0022 17.6 11.0 0.004 16.8 11.0 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TMEM119 PF15724.5 EKE41322.1 - 2.2 8.3 7.3 3.5 7.6 7.3 1.2 1 0 0 1 1 1 0 TMEM119 family Gelsolin PF00626.22 EKE41323.1 - 4e-36 122.8 0.2 1.4e-13 50.5 0.0 4.8 4 0 0 4 4 4 4 Gelsolin repeat VHP PF02209.19 EKE41323.1 - 1.9e-10 40.6 7.6 6e-10 39.0 7.6 1.9 1 0 0 1 1 1 1 Villin headpiece domain GOLD_2 PF13897.6 EKE41323.1 - 0.17 12.4 1.7 0.7 10.4 0.1 2.8 3 0 0 3 3 3 0 Golgi-dynamics membrane-trafficking PhoLip_ATPase_C PF16212.5 EKE41324.1 - 1.3e-56 192.1 31.8 1.3e-56 192.1 31.8 1.8 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EKE41324.1 - 4.1e-11 43.6 6.0 3.4e-05 24.2 2.6 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EKE41324.1 - 6.2e-10 38.9 0.1 6.2e-10 38.9 0.1 2.5 2 0 0 2 2 2 1 E1-E2 ATPase PhoLip_ATPase_N PF16209.5 EKE41324.1 - 6.6e-05 22.5 0.6 0.0022 17.6 0.0 3.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Sushi_2 PF09014.10 EKE41324.1 - 0.13 12.2 0.1 0.13 12.2 0.1 3.1 3 0 0 3 3 3 0 Beta-2-glycoprotein-1 fifth domain Hydrolase_3 PF08282.12 EKE41324.1 - 3.2 7.4 30.1 0.12 12.1 14.4 4.6 2 2 0 3 3 3 0 haloacid dehalogenase-like hydrolase RRM_1 PF00076.22 EKE41325.1 - 5.1e-15 55.1 0.0 9.2e-15 54.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKE41325.1 - 1.4e-05 24.7 0.0 1.8e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PDCD2_C PF04194.13 EKE41326.1 - 2e-34 119.2 1.2 5.8e-32 111.2 0.2 2.2 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain zf-HIT PF04438.16 EKE41326.1 - 0.002 18.0 10.9 0.002 18.0 10.9 4.1 4 0 0 4 4 4 1 HIT zinc finger CpXC PF14353.6 EKE41326.1 - 0.23 11.5 0.1 0.23 11.5 0.1 3.7 3 2 0 3 3 3 0 CpXC protein LRR_5 PF13306.6 EKE41327.1 - 7.2e-39 132.7 23.9 9.9e-25 87.0 12.7 2.6 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE41327.1 - 5.4e-09 35.7 1.1 0.00067 19.4 0.0 4.5 2 2 2 4 4 4 2 Leucine rich repeat Metallophos PF00149.28 EKE41329.1 - 7.4e-09 36.4 0.1 1.1e-08 35.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE41329.1 - 0.0098 16.1 0.0 4.1 7.6 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain STAG PF08514.11 EKE41331.1 - 0.045 13.7 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 STAG domain tRNA-synt_1c PF00749.21 EKE41332.1 - 7e-108 360.2 0.6 1.4e-107 359.2 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EKE41332.1 - 3.7e-49 166.9 0.2 3.1e-48 163.9 0.0 2.6 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R1 PF04558.15 EKE41332.1 - 2.7e-40 138.0 4.0 2.7e-40 138.0 4.0 2.0 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 DUF4460 PF14687.6 EKE41332.1 - 0.044 13.8 0.2 3.6 7.7 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4460) tRNA_synt_1c_R2 PF04557.15 EKE41332.1 - 0.27 12.2 9.9 0.93 10.5 9.9 2.0 1 1 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 GATA PF00320.27 EKE41333.1 - 1.1e-10 40.9 5.6 2.5e-10 39.8 5.6 1.6 1 0 0 1 1 1 1 GATA zinc finger Sulfotransfer_3 PF13469.6 EKE41334.1 - 8.7e-26 91.6 0.0 1.7e-25 90.7 0.0 1.5 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 EKE41334.1 - 2e-07 30.7 6.0 2.4e-06 27.2 6.0 2.3 1 1 0 1 1 1 1 Sulfotransferase domain SRPRB PF09439.10 EKE41334.1 - 0.06 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit UCH PF00443.29 EKE41335.1 - 4e-38 131.4 8.2 4e-38 131.4 8.2 3.9 4 1 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE41335.1 - 1.1e-05 25.2 11.1 1.1e-05 25.2 11.1 2.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF4485 PF14846.6 EKE41335.1 - 0.11 12.5 5.2 2.5 8.2 1.4 3.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4485) Pkinase PF00069.25 EKE41336.1 - 1.5e-27 96.6 0.0 3.3e-27 95.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41336.1 - 2.7e-14 53.1 0.0 4e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PTPlike_phytase PF14566.6 EKE41336.1 - 0.082 13.0 0.5 0.19 11.8 0.5 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate Rad17 PF03215.15 EKE41337.1 - 2.1e-11 44.1 0.5 7.4e-11 42.3 0.5 1.9 1 0 0 1 1 1 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 EKE41337.1 - 3.9e-05 23.6 0.1 8.1e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 EKE41337.1 - 7.7e-05 23.2 0.6 0.00017 22.1 0.6 1.7 1 1 0 1 1 1 1 ABC transporter AAA PF00004.29 EKE41337.1 - 0.00026 21.4 0.0 0.00071 20.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EKE41337.1 - 0.00031 20.8 0.1 0.0012 18.8 0.1 2.1 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EKE41337.1 - 0.00034 19.9 0.7 0.00077 18.7 0.1 1.9 2 0 0 2 2 2 1 NB-ARC domain T2SSE PF00437.20 EKE41337.1 - 0.00039 19.6 0.0 0.0007 18.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein ATPase_2 PF01637.18 EKE41337.1 - 0.00049 20.1 1.1 0.00096 19.1 0.2 1.9 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EKE41337.1 - 0.002 18.4 0.0 0.0096 16.2 0.0 2.2 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.6 EKE41337.1 - 0.004 17.7 0.1 0.086 13.4 0.1 2.6 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.19 EKE41337.1 - 0.0048 16.4 0.1 0.011 15.2 0.1 1.6 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 EKE41337.1 - 0.0055 17.0 0.0 0.01 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain RNA12 PF10443.9 EKE41337.1 - 0.0057 15.4 0.3 0.0057 15.4 0.3 1.6 2 0 0 2 2 2 1 RNA12 protein ASCH PF04266.14 EKE41337.1 - 0.0071 16.9 1.5 0.022 15.3 0.3 2.3 2 0 0 2 2 2 1 ASCH domain AAA_7 PF12775.7 EKE41337.1 - 0.0081 15.7 0.0 0.016 14.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region NACHT PF05729.12 EKE41337.1 - 0.011 15.7 0.0 0.031 14.2 0.1 1.8 2 0 0 2 2 1 0 NACHT domain AAA_23 PF13476.6 EKE41337.1 - 0.022 15.3 0.1 0.022 15.3 0.1 3.1 2 1 0 2 2 1 0 AAA domain Tfb5 PF06331.12 EKE41337.1 - 0.024 14.6 0.3 6.8 6.8 0.1 2.6 2 0 0 2 2 2 0 Transcription factor TFIIH complex subunit Tfb5 Viral_helicase1 PF01443.18 EKE41337.1 - 0.025 14.3 0.0 0.061 13.1 0.0 1.7 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 EKE41337.1 - 0.026 14.5 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 EKE41337.1 - 0.032 14.6 0.0 0.063 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 EKE41337.1 - 0.033 13.5 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin RNase_P_Rpp14 PF01900.19 EKE41337.1 - 0.04 14.2 0.0 0.1 12.9 0.0 1.7 1 0 0 1 1 1 0 Rpp14/Pop5 family AAA_21 PF13304.6 EKE41337.1 - 0.049 13.4 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system HTH_45 PF14947.6 EKE41337.1 - 0.062 13.3 0.9 2.4 8.2 0.2 2.7 2 1 0 2 2 2 0 Winged helix-turn-helix AAA_24 PF13479.6 EKE41337.1 - 0.064 13.0 1.3 1.1 9.0 0.5 2.9 3 1 0 3 3 3 0 AAA domain AAA_assoc_2 PF16193.5 EKE41337.1 - 0.067 13.5 0.0 0.23 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA C-terminal domain SKI PF01202.22 EKE41337.1 - 0.084 13.0 0.2 0.18 11.9 0.2 1.6 1 0 0 1 1 1 0 Shikimate kinase AAA_25 PF13481.6 EKE41337.1 - 0.17 11.4 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EKE41337.1 - 0.18 11.5 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain SBDS_C PF09377.10 EKE41337.1 - 0.19 11.7 3.2 0.97 9.5 3.2 2.5 1 1 0 1 1 1 0 SBDS protein C-terminal domain AAA_33 PF13671.6 EKE41337.1 - 0.2 11.8 0.0 0.41 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EKE41337.1 - 0.38 11.2 2.9 0.52 10.7 0.0 2.7 3 0 0 3 3 2 0 RNA helicase Fungal_lectin_2 PF18647.1 EKE41337.1 - 8.7 6.9 8.7 2 8.9 3.3 2.6 2 1 0 2 2 2 0 Alpha-galactosyl-binding fungal lectin LRR_5 PF13306.6 EKE41338.1 - 3.1e-52 175.9 47.7 2.3e-18 66.4 5.8 4.9 5 1 0 5 5 5 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE41338.1 - 1.4e-10 40.7 10.9 0.022 14.5 0.3 7.7 5 4 6 11 11 11 7 Leucine rich repeat LRR_4 PF12799.7 EKE41338.1 - 0.00013 22.2 19.0 4.4 7.9 4.2 6.7 4 3 2 6 6 6 5 Leucine Rich repeats (2 copies) DUF4216 PF13952.6 EKE41338.1 - 0.16 12.4 1.1 1.1 9.7 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4216) Macro PF01661.21 EKE41339.1 - 7.5e-32 109.9 0.1 2.3e-31 108.3 0.0 1.8 2 0 0 2 2 2 1 Macro domain SIR2 PF02146.17 EKE41339.1 - 5.3e-07 29.7 0.3 4.4e-05 23.5 0.0 2.7 2 0 0 2 2 2 1 Sir2 family Cnd1 PF12717.7 EKE41339.1 - 0.021 14.9 4.5 0.85 9.6 3.7 2.3 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Ras_bdg_2 PF14847.6 EKE41339.1 - 0.25 11.7 4.6 0.085 13.2 0.8 2.1 2 0 0 2 2 2 0 Ras-binding domain of Byr2 4HBT PF03061.22 EKE41341.1 - 0.015 15.6 0.2 0.023 15.0 0.2 1.4 1 1 0 1 1 1 0 Thioesterase superfamily ATP-synt_ab PF00006.25 EKE41341.1 - 0.14 11.8 0.1 0.17 11.5 0.1 1.1 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Exo_endo_phos PF03372.23 EKE41342.1 - 5.8e-08 32.5 0.0 9e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Tubulin PF00091.25 EKE41343.1 - 6e-11 42.9 0.2 6.3e-11 42.8 0.2 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain RabGAP-TBC PF00566.18 EKE41344.1 - 1.9e-38 132.3 1.9 2.4e-38 132.0 1.9 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1129 PF06570.11 EKE41345.1 - 0.0036 16.8 3.8 0.0036 16.8 3.8 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1129) DUF3754 PF12576.8 EKE41345.1 - 0.023 14.6 0.3 0.051 13.5 0.1 1.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3754) 7TMR-DISM_7TM PF07695.11 EKE41345.1 - 0.058 13.3 11.9 0.22 11.4 7.5 2.1 2 0 0 2 2 2 0 7TM diverse intracellular signalling DUF2207 PF09972.9 EKE41345.1 - 0.12 11.1 5.1 0.9 8.2 5.1 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Tetraspanin PF00335.20 EKE41345.1 - 0.18 11.5 20.2 3.1 7.5 20.2 2.8 1 1 0 1 1 1 0 Tetraspanin family DUF202 PF02656.15 EKE41345.1 - 0.22 12.0 0.3 0.22 12.0 0.3 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF202) Xan_ur_permease PF00860.20 EKE41345.1 - 0.3 9.7 7.0 0.082 11.6 4.4 1.4 1 1 0 1 1 1 0 Permease family ECF_trnsprt PF12822.7 EKE41345.1 - 2.3 8.3 15.2 7.5 6.6 15.2 1.8 1 1 0 1 1 1 0 ECF transporter, substrate-specific component DUF2569 PF10754.9 EKE41345.1 - 2.7 8.4 10.7 2.1 8.8 7.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) DUF3188 PF11384.8 EKE41345.1 - 9.3 6.1 9.2 18 5.1 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3188) YfzA PF14118.6 EKE41345.1 - 10 6.6 9.7 15 6.1 0.8 2.9 3 0 0 3 3 3 0 YfzA-like protein DENN PF02141.21 EKE41346.1 - 4.2e-17 62.7 5.4 1.3e-16 61.1 5.4 1.8 1 0 0 1 1 1 1 DENN (AEX-3) domain DSPc PF00782.20 EKE41348.1 - 2.2e-08 34.0 0.0 4.5e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EKE41348.1 - 2.1e-05 24.2 0.2 6.5e-05 22.6 0.1 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EKE41348.1 - 0.00026 21.0 0.0 0.00041 20.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EKE41348.1 - 0.012 15.2 0.1 0.022 14.3 0.1 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Myotub-related PF06602.14 EKE41348.1 - 0.031 13.2 0.0 0.048 12.6 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain PTPlike_phytase PF14566.6 EKE41348.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF4870 PF09685.10 EKE41349.1 - 0.0019 18.3 19.4 0.0024 17.9 19.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4870) DUF3902 PF13042.6 EKE41349.1 - 0.094 12.3 13.8 0.065 12.8 12.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3902) PSI PF01437.25 EKE41350.1 - 0.0023 18.4 32.2 0.06 13.9 11.1 2.3 2 0 0 2 2 2 2 Plexin repeat DUF3611 PF12263.8 EKE41350.1 - 0.01 15.7 0.2 0.017 15.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) DUF4366 PF14283.6 EKE41350.1 - 0.17 11.9 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF4672 PF15716.5 EKE41350.1 - 0.99 9.0 6.3 1.9 8.1 6.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) COMM_domain PF07258.14 EKE41353.1 - 1.1e-11 44.6 0.1 2.3e-11 43.7 0.1 1.5 1 0 0 1 1 1 1 COMM domain DUF4298 PF14131.6 EKE41353.1 - 0.02 14.8 1.3 8.7 6.4 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) Trp_repressor PF01371.19 EKE41353.1 - 0.1 12.8 1.4 3.3 7.9 0.1 2.6 2 0 0 2 2 2 0 Trp repressor protein Proteasome PF00227.26 EKE41354.1 - 1.9e-43 148.2 0.0 2.2e-43 148.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Mic1 PF07035.12 EKE41355.1 - 1.5e-13 50.8 0.3 4.5e-13 49.2 0.3 1.8 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like PP2C_2 PF13672.6 EKE41356.1 - 3.6e-08 33.3 0.0 7.6e-08 32.2 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE41356.1 - 0.00028 20.9 0.0 0.00058 19.8 0.0 1.5 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EKE41356.1 - 0.023 14.3 0.6 0.07 12.7 0.1 1.9 2 0 0 2 2 2 0 Protein phosphatase 2C DUF1057 PF06342.12 EKE41357.1 - 2.7e-07 29.9 0.0 3.7e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_2 PF02230.16 EKE41357.1 - 6.7e-05 22.8 0.0 0.03 14.1 0.0 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EKE41357.1 - 8.8e-05 22.1 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EKE41357.1 - 0.00029 20.2 0.0 0.24 10.6 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DUF829 PF05705.14 EKE41357.1 - 0.038 13.9 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) LIDHydrolase PF10230.9 EKE41357.1 - 0.089 12.3 0.1 1.4 8.4 0.0 2.2 1 1 1 2 2 2 0 Lipid-droplet associated hydrolase Abhydrolase_3 PF07859.13 EKE41357.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.11 EKE41357.1 - 0.14 12.1 0.4 11 5.8 0.0 2.2 1 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal PseudoU_synth_2 PF00849.22 EKE41358.1 - 7.7e-26 91.1 0.1 1.6e-25 90.1 0.1 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 EKE41358.1 - 0.019 14.7 0.2 0.019 14.7 0.2 2.2 3 0 0 3 3 3 0 S4 domain TruB_N PF01509.18 EKE41358.1 - 0.03 14.7 0.2 1.4 9.3 0.0 2.3 2 0 0 2 2 2 0 TruB family pseudouridylate synthase (N terminal domain) HSP70 PF00012.20 EKE41359.1 - 1.5e-29 102.7 4.9 8.9e-24 83.6 3.3 4.2 2 1 2 4 4 4 2 Hsp70 protein TPR_1 PF00515.28 EKE41359.1 - 1.9e-10 40.1 1.8 0.00062 19.5 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat MreB_Mbl PF06723.13 EKE41359.1 - 7.7e-09 34.8 2.2 1.3e-08 34.0 2.2 1.5 1 0 0 1 1 1 1 MreB/Mbl protein TPR_2 PF07719.17 EKE41359.1 - 7.4e-06 25.7 1.2 0.069 13.3 0.2 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE41359.1 - 0.00013 22.1 0.2 0.00037 20.7 0.2 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EKE41359.1 - 0.00052 20.3 0.6 0.016 15.5 0.6 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TssO PF17561.2 EKE41359.1 - 0.0014 18.8 7.6 0.0014 18.8 7.6 2.8 1 1 1 2 2 2 1 Type VI secretion system, TssO DUF1786 PF08735.10 EKE41359.1 - 0.003 16.9 0.4 0.0072 15.6 0.0 1.8 2 0 0 2 2 2 1 Putative pyruvate format-lyase activating enzyme (DUF1786) Gemini_AL1_M PF08283.11 EKE41359.1 - 0.014 15.5 0.5 0.035 14.2 0.5 1.7 1 0 0 1 1 1 0 Geminivirus rep protein central domain DUF4291 PF14124.6 EKE41359.1 - 0.11 12.4 3.3 0.17 11.8 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4291) TPR_6 PF13174.6 EKE41359.1 - 0.12 13.1 1.2 31 5.5 0.1 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EKE41359.1 - 0.15 12.3 0.1 0.15 12.3 0.1 4.2 5 0 0 5 5 3 0 Tetratricopeptide repeat SpoOE-like PF09388.10 EKE41359.1 - 1.8 8.6 16.2 1.2 9.1 0.1 3.8 4 0 0 4 4 4 0 Spo0E like sporulation regulatory protein Rap_GAP PF02145.15 EKE41360.1 - 8.5e-56 188.5 1.8 2e-55 187.2 1.8 1.7 1 0 0 1 1 1 1 Rap/ran-GAP RRM_1 PF00076.22 EKE41361.1 - 3.8e-26 90.7 2.6 1.5e-14 53.6 0.3 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKE41361.1 - 2.1e-10 40.3 0.2 2.1e-07 30.6 0.1 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKE41361.1 - 1.1e-09 38.0 0.6 6.9e-06 25.8 0.1 2.4 2 0 0 2 2 2 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EKE41361.1 - 1.1e-07 31.8 0.4 0.017 15.1 0.0 2.6 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif DUF4523 PF15023.6 EKE41361.1 - 0.00013 21.8 0.1 0.047 13.5 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF4523) RRM_3 PF08777.11 EKE41361.1 - 0.0024 17.9 1.3 0.039 14.0 0.1 2.4 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM PF05172.13 EKE41361.1 - 0.0098 15.8 1.2 0.031 14.2 0.6 2.1 1 1 1 2 2 2 1 Nup53/35/40-type RNA recognition motif RL PF17797.1 EKE41361.1 - 0.037 14.0 2.7 4.7 7.2 0.1 2.6 2 0 0 2 2 2 0 RL domain DTHCT PF08070.11 EKE41362.1 - 2 9.2 8.9 1.3 9.8 3.2 2.4 1 1 1 2 2 2 0 DTHCT (NUC029) region Sec10 PF07393.11 EKE41363.1 - 1.3e-42 146.1 39.8 1e-23 83.7 5.8 2.4 2 1 1 3 3 3 2 Exocyst complex component Sec10 ERp29_N PF07912.13 EKE41363.1 - 0.034 14.3 4.3 0.17 12.0 0.8 2.7 2 0 0 2 2 2 0 ERp29, N-terminal domain PBD PF00786.28 EKE41364.1 - 2.4e-05 24.6 0.2 8.3e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 P21-Rho-binding domain AAA_23 PF13476.6 EKE41365.1 - 9.5e-28 98.1 19.9 9.5e-28 98.1 19.9 9.8 1 1 4 5 5 5 1 AAA domain SMC_N PF02463.19 EKE41365.1 - 1.2e-07 31.4 0.0 1.2e-07 31.4 0.0 6.0 4 2 1 5 5 5 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EKE41365.1 - 4.6e-05 23.6 0.1 0.00021 21.5 0.0 2.2 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 EKE41365.1 - 8.4e-05 22.4 194.8 0.00025 20.9 46.5 5.4 1 1 3 4 4 4 2 AAA ATPase domain AAA_29 PF13555.6 EKE41365.1 - 0.00039 20.1 0.0 0.00083 19.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EKE41365.1 - 0.017 15.0 0.0 0.017 15.0 0.0 6.2 3 2 2 5 5 5 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 EKE41365.1 - 0.029 14.1 0.0 0.12 12.0 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EKE41365.1 - 0.14 12.6 0.0 0.14 12.6 0.0 3.4 3 1 0 3 3 3 0 AAA ATPase domain ABC_tran PF00005.27 EKE41365.1 - 0.22 12.1 0.0 0.22 12.1 0.0 9.1 2 1 1 4 4 4 0 ABC transporter AAA_22 PF13401.6 EKE41365.1 - 3.1 8.1 10.7 0.73 10.1 0.0 4.2 3 0 0 3 3 3 0 AAA domain LRR_5 PF13306.6 EKE41366.1 - 1e-53 180.7 32.2 2.5e-25 88.9 1.2 4.1 1 1 2 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE41366.1 - 5.8e-16 58.0 0.7 0.0041 16.8 0.0 6.3 3 1 4 7 7 7 6 Leucine rich repeat Swi5 PF07061.11 EKE41367.1 - 0.032 14.3 0.1 0.091 12.9 0.1 1.8 1 0 0 1 1 1 0 Swi5 HECT PF00632.25 EKE41370.1 - 5.1e-92 308.6 1.1 5.1e-92 308.6 1.1 2.7 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Cu PF17563.2 EKE41370.1 - 0.7 10.2 2.5 12 6.2 0.0 2.8 2 0 0 2 2 2 0 Cupiennin DUF3782 PF12644.7 EKE41370.1 - 1.2 9.3 0.0 1.2 9.3 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3782) DUF4283 PF14111.6 EKE41371.1 - 0.015 14.8 0.1 0.18 11.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4283) Telomere_reg-2 PF10193.9 EKE41371.1 - 0.024 15.1 1.1 0.024 15.1 1.1 2.4 2 0 0 2 2 2 0 Telomere length regulation protein SpoIIAA-like PF11964.8 EKE41371.1 - 1.4 10.0 6.0 0.68 11.0 0.8 2.5 2 1 1 3 3 3 0 SpoIIAA-like RL PF17797.1 EKE41371.1 - 1.7 8.7 5.6 0.95 9.5 0.1 3.0 3 0 0 3 3 3 0 RL domain Apyrase PF06079.11 EKE41372.1 - 3.9e-101 338.1 1.5 4.7e-101 337.8 1.5 1.0 1 0 0 1 1 1 1 Apyrase Ribosomal_L7Ae PF01248.26 EKE41373.1 - 2e-24 85.1 0.1 2.5e-24 84.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EKE41373.1 - 0.00014 21.6 0.0 0.0002 21.2 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 EKE41373.1 - 0.00016 21.8 0.0 0.00016 21.8 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 SprT-like PF10263.9 EKE41374.1 - 5.9e-22 77.7 0.8 9.6e-22 77.0 0.8 1.3 1 0 0 1 1 1 1 SprT-like family BolA PF01722.18 EKE41374.1 - 0.087 13.1 0.4 2.3 8.6 0.0 2.6 2 1 0 2 2 2 0 BolA-like protein Tox-HDC PF15656.6 EKE41374.1 - 0.14 12.4 3.2 0.23 11.7 0.2 2.6 2 1 1 3 3 3 0 Toxin with a H, D/N and C signature LRR_4 PF12799.7 EKE41375.1 - 1.7e-06 28.2 12.0 0.043 14.3 0.1 4.7 3 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EKE41375.1 - 5.8e-06 25.9 3.3 5.8e-06 25.9 3.3 2.6 2 1 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 EKE41375.1 - 4.1e-05 23.2 9.0 0.36 10.6 0.0 4.1 3 1 1 4 4 4 3 Leucine rich repeat MIG-14_Wnt-bd PF06664.12 EKE41376.1 - 1e-20 74.2 38.0 1.7e-20 73.4 38.0 1.3 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion PRIMA1 PF16101.5 EKE41376.1 - 0.48 10.5 4.1 0.25 11.4 0.4 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Orf78 PF06024.12 EKE41376.1 - 1.2 9.4 9.0 11 6.4 2.4 3.0 2 0 0 2 2 2 0 Orf78 (ac78) Vpu PF00558.19 EKE41376.1 - 3.2 7.6 7.4 0.23 11.3 0.8 2.4 2 0 0 2 2 2 0 Vpu protein ATP-synt_D PF01813.17 EKE41377.1 - 3.6e-65 219.5 6.2 5.1e-65 219.0 6.2 1.2 1 0 0 1 1 1 1 ATP synthase subunit D RRM_1 PF00076.22 EKE41378.1 - 6.5e-36 122.0 3.9 1.9e-17 62.8 0.2 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 EKE41378.1 - 1.3e-05 24.7 0.7 0.12 12.1 0.1 2.5 2 0 0 2 2 2 2 Ribonuclease B OB domain RRM_Rrp7 PF17799.1 EKE41378.1 - 0.0051 16.6 0.3 0.011 15.6 0.1 1.6 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain TLD PF07534.16 EKE41379.1 - 0.045 14.0 3.8 0.12 12.6 3.8 1.9 1 1 0 1 1 1 0 TLD DUF533 PF04391.12 EKE41379.1 - 0.22 11.0 0.3 0.37 10.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Beach PF02138.18 EKE41380.1 - 6.7e-106 353.7 1.4 1.2e-105 352.9 1.4 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EKE41380.1 - 4.7e-08 33.1 6.7 6.6e-06 26.1 1.5 3.7 2 2 0 2 2 2 2 PH domain associated with Beige/BEACH GRAM PF02893.20 EKE41380.1 - 0.0049 16.7 6.6 0.33 10.8 0.1 3.1 3 0 0 3 3 3 2 GRAM domain HEAT_2 PF13646.6 EKE41381.1 - 1.4e-09 38.2 0.2 3.6 8.1 0.0 7.4 6 1 2 8 8 8 2 HEAT repeats HEAT PF02985.22 EKE41381.1 - 5.6e-07 29.3 9.0 2.2 8.8 0.0 8.7 10 0 0 10 10 10 1 HEAT repeat HEAT_EZ PF13513.6 EKE41381.1 - 6.5e-05 23.3 0.0 3 8.4 0.0 5.8 5 0 0 5 5 5 1 HEAT-like repeat Cnd1 PF12717.7 EKE41381.1 - 0.00051 20.1 9.8 0.019 15.0 0.1 5.8 3 1 2 6 6 6 1 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 EKE41381.1 - 0.0019 18.1 6.4 2.8 7.8 0.0 5.7 5 1 0 6 6 6 1 Domain of unknown function (DUF3385) MMS19_C PF12460.8 EKE41381.1 - 0.007 15.5 3.0 4.8 6.2 0.7 4.1 3 1 0 3 3 3 2 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 EKE41381.1 - 0.011 16.4 10.9 15 6.3 0.1 6.6 7 0 0 7 7 7 0 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 EKE41381.1 - 0.045 13.5 2.7 6.4 6.5 0.2 2.8 2 1 0 2 2 2 0 rRNA processing/ribosome biogenesis GrpE PF01025.19 EKE41381.1 - 0.048 13.3 3.5 9 5.9 0.1 3.2 3 0 0 3 3 3 0 GrpE Dopey_N PF04118.14 EKE41381.1 - 5.2 6.1 8.6 19 4.2 0.2 4.1 2 1 2 5 5 5 0 Dopey, N-terminal Pup PF05639.11 EKE41383.1 - 0.00086 20.2 0.2 0.034 15.0 0.0 3.4 3 0 0 3 3 3 1 Pup-like protein TBCC_N PF16752.5 EKE41383.1 - 0.087 13.3 1.6 0.17 12.3 0.1 2.2 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain HSBP1 PF06825.12 EKE41383.1 - 1.4 8.8 6.2 2.9 7.8 0.3 2.8 3 0 0 3 3 3 0 Heat shock factor binding protein 1 Lipase_3 PF01764.25 EKE41385.1 - 1.7e-05 24.7 0.0 3.4e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) UPF0227 PF05728.12 EKE41385.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Abhydrolase_5 PF12695.7 EKE41385.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family WD40 PF00400.32 EKE41386.1 - 1.2e-31 108.2 18.8 9.2e-05 23.1 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE41386.1 - 1.8e-15 57.0 1.8 0.0022 18.2 0.2 5.6 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EKE41386.1 - 6.7e-12 45.7 1.4 1.9e-05 24.7 0.1 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 EKE41386.1 - 0.011 14.8 0.0 0.54 9.2 0.0 2.1 2 0 0 2 2 2 0 Coatomer WD associated region DnaJ PF00226.31 EKE41387.1 - 2.2e-16 59.7 2.8 2.2e-16 59.7 2.8 2.4 3 1 0 3 3 3 1 DnaJ domain RPT PF13446.6 EKE41387.1 - 0.0069 16.3 0.0 0.024 14.6 0.0 1.9 1 0 0 1 1 1 1 A repeated domain in UCH-protein DUF3349 PF11829.8 EKE41387.1 - 0.23 12.3 3.7 0.94 10.3 1.7 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3349) DsrC PF04358.13 EKE41387.1 - 0.25 11.8 5.0 0.17 12.4 1.6 2.3 2 1 0 2 2 2 0 DsrC like protein Pkinase_Tyr PF07714.17 EKE41388.1 - 1.6e-58 198.0 0.0 2.4e-58 197.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41388.1 - 4.9e-45 153.9 0.0 7.9e-45 153.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE41388.1 - 0.00013 20.9 0.0 0.00032 19.6 0.0 1.6 1 1 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE41388.1 - 0.0063 15.9 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family fn3_5 PF06280.12 EKE41388.1 - 0.13 13.0 1.3 0.27 11.9 0.7 1.8 1 1 1 2 2 2 0 Fn3-like domain APH PF01636.23 EKE41388.1 - 0.13 12.2 0.1 0.3 11.0 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF3244 PF11589.8 EKE41388.1 - 0.19 11.8 1.9 3.7 7.7 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3244) APH_6_hur PF04655.14 EKE41388.1 - 0.2 11.0 0.0 5.2 6.4 0.0 2.1 2 0 0 2 2 2 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase KASH_CCD PF14662.6 EKE41389.1 - 0.0045 16.8 16.9 0.032 14.1 12.4 2.0 1 1 1 2 2 2 1 Coiled-coil region of CCDC155 or KASH bZIP_1 PF00170.21 EKE41389.1 - 0.03 14.4 13.1 0.21 11.7 8.7 2.4 1 1 1 2 2 2 0 bZIP transcription factor LRRFIP PF09738.9 EKE41389.1 - 0.051 13.1 13.5 0.45 10.0 0.1 2.1 1 1 1 2 2 2 0 LRRFIP family Lectin_N PF03954.14 EKE41389.1 - 0.077 12.7 3.7 0.1 12.4 3.7 1.2 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Atg14 PF10186.9 EKE41389.1 - 0.16 11.0 6.2 0.2 10.7 6.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Retrotrans_gag PF03732.17 EKE41389.1 - 0.19 12.0 1.9 0.17 12.2 0.7 1.5 2 0 0 2 2 2 0 Retrotransposon gag protein Fungal_TACC PF12709.7 EKE41389.1 - 0.21 12.1 14.8 1.5 9.3 9.5 2.7 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins YabA PF06156.13 EKE41389.1 - 0.26 11.9 13.0 0.25 12.0 9.9 2.0 1 1 1 2 2 2 0 Initiation control protein YabA HIP1_clath_bdg PF16515.5 EKE41389.1 - 0.27 11.9 10.3 0.32 11.6 9.8 1.3 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DivIC PF04977.15 EKE41389.1 - 0.28 11.0 11.7 0.56 10.0 7.8 2.2 1 1 1 2 2 2 0 Septum formation initiator DUF3450 PF11932.8 EKE41389.1 - 0.31 10.3 7.6 0.59 9.4 5.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Ax_dynein_light PF10211.9 EKE41389.1 - 0.34 10.8 13.1 8 6.4 11.7 2.1 1 1 2 3 3 3 0 Axonemal dynein light chain zf-C4H2 PF10146.9 EKE41389.1 - 0.78 10.0 10.1 0.97 9.7 10.1 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein DUF1664 PF07889.12 EKE41389.1 - 1 9.4 6.9 3.4 7.7 6.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) GrpE PF01025.19 EKE41389.1 - 1.1 8.9 12.5 0.6 9.7 10.1 1.7 1 1 1 2 2 2 0 GrpE DUF4795 PF16043.5 EKE41389.1 - 2.2 7.9 14.5 5.1 6.6 10.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) TSC22 PF01166.18 EKE41389.1 - 2.6 8.4 11.2 27 5.2 7.9 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family tRNA-synt_1d PF00750.19 EKE41390.1 - 1.4e-95 320.2 2.6 1.9e-95 319.8 2.6 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EKE41390.1 - 2.7e-26 92.1 0.0 8.7e-26 90.4 0.0 1.9 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EKE41390.1 - 1.7e-13 51.0 0.5 6.4e-13 49.1 0.5 2.1 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain Peptidase_C1 PF00112.23 EKE41391.1 - 1.9e-08 34.7 2.7 7.1e-08 32.8 0.4 2.2 2 0 0 2 2 2 1 Papain family cysteine protease Phage_holin_6_1 PF09682.10 EKE41391.1 - 0.1 13.0 0.1 0.27 11.7 0.1 1.7 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Peptidase_C39_2 PF13529.6 EKE41391.1 - 0.5 10.9 3.3 0.74 10.4 1.1 2.5 2 1 0 2 2 2 0 Peptidase_C39 like family RasGEF PF00617.19 EKE41392.1 - 7.3e-30 104.5 0.5 2.1e-29 103.0 0.5 1.9 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE41392.1 - 0.00016 21.9 0.2 0.0012 19.1 0.0 2.7 2 0 0 2 2 2 1 RasGEF N-terminal motif HSBP1 PF06825.12 EKE41392.1 - 0.11 12.3 1.9 0.49 10.3 0.5 2.7 2 0 0 2 2 2 0 Heat shock factor binding protein 1 DUF948 PF06103.11 EKE41392.1 - 5.3 7.4 6.0 5.5 7.3 0.1 3.6 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) RasGEF PF00617.19 EKE41393.1 - 3.4e-13 50.2 3.6 8.1e-13 49.0 3.6 1.6 1 0 0 1 1 1 1 RasGEF domain DUF1765 PF08578.10 EKE41394.1 - 5.4e-11 43.0 0.9 5.4e-11 43.0 0.9 3.1 3 1 0 3 3 3 1 Protein of unknown function (DUF1765) Imm5 PF14423.6 EKE41395.1 - 0.11 12.7 3.7 0.12 12.6 0.7 2.0 2 0 0 2 2 2 0 Immunity protein Imm5 FYVE PF01363.21 EKE41396.1 - 0.00078 19.5 9.9 0.0025 17.9 9.9 1.9 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 EKE41396.1 - 0.021 15.0 7.6 0.21 11.8 7.6 2.8 1 0 0 1 1 1 0 FYVE-type zinc finger DUF969 PF06149.12 EKE41396.1 - 0.043 13.2 0.4 0.94 8.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF969) RPN6_N PF18055.1 EKE41396.1 - 0.082 13.3 1.3 0.41 11.0 0.9 2.4 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain Zn_Tnp_IS1595 PF12760.7 EKE41396.1 - 0.089 12.8 2.9 0.29 11.1 2.9 1.9 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Seryl_tRNA_N PF02403.22 EKE41398.1 - 1.3e-05 25.4 9.3 1.3e-05 25.4 9.3 5.5 2 1 3 5 5 5 3 Seryl-tRNA synthetase N-terminal domain DivIC PF04977.15 EKE41398.1 - 0.0035 17.1 1.6 0.0035 17.1 1.6 7.7 3 1 5 8 8 8 2 Septum formation initiator ADIP PF11559.8 EKE41398.1 - 0.0093 16.1 13.3 0.0093 16.1 13.3 5.5 2 1 3 5 5 5 1 Afadin- and alpha -actinin-Binding DUF2935 PF11155.8 EKE41398.1 - 8.4 6.8 17.5 29 5.0 0.7 4.0 2 2 0 2 2 2 0 Domain of unknown function (DUF2935) RNA_pol_L_2 PF13656.6 EKE41399.1 - 1.1e-23 82.8 0.4 1.3e-23 82.5 0.4 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EKE41399.1 - 8.5e-09 34.7 0.0 1.3e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Pkinase_Tyr PF07714.17 EKE41400.1 - 3.8e-37 128.0 0.0 4.7e-37 127.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41400.1 - 6.1e-33 114.3 0.0 8e-33 113.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EKE41400.1 - 0.0059 16.0 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EKE41400.1 - 0.11 12.1 1.6 2 8.0 0.1 2.6 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 DUF2312 PF10073.9 EKE41400.1 - 0.35 10.5 1.9 0.86 9.3 0.3 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) F-box PF00646.33 EKE41401.1 - 0.0041 17.0 2.4 0.017 15.0 0.3 3.1 3 0 0 3 3 3 1 F-box domain RRM_Rrp7 PF17799.1 EKE41401.1 - 0.92 9.3 5.5 0.23 11.2 1.0 2.1 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain SID PF11778.8 EKE41401.1 - 3.3 7.8 10.0 0.36 10.9 0.3 3.2 3 0 0 3 3 3 0 Septation initiation RasGEF PF00617.19 EKE41402.1 - 0.0011 19.1 0.3 0.0031 17.7 0.3 1.8 1 0 0 1 1 1 1 RasGEF domain DUF3979 PF13141.6 EKE41402.1 - 0.03 14.6 3.3 0.82 10.0 0.3 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3979) EF1_GNE PF00736.19 EKE41403.1 - 1.3e-27 95.8 0.6 2e-27 95.2 0.6 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain BAR_3_WASP_bdg PF10456.9 EKE41403.1 - 0.062 12.8 2.0 1.8 8.0 0.4 2.0 1 1 1 2 2 2 0 WASP-binding domain of Sorting nexin protein Ribosomal_L27e PF01777.18 EKE41405.1 - 9.9e-25 86.7 5.4 1.5e-24 86.1 5.4 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EKE41405.1 - 1.8e-06 27.7 1.8 4.5e-06 26.4 1.8 1.8 1 0 0 1 1 1 1 KOW motif DUF5033 PF16436.5 EKE41405.1 - 0.015 15.3 0.1 0.017 15.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5033) Invasin_D3 PF09134.10 EKE41408.1 - 7.6e-05 22.9 15.4 0.0011 19.2 0.5 6.0 6 1 1 7 7 7 2 Invasin, domain 3 Big_2 PF02368.18 EKE41408.1 - 0.0051 16.7 40.8 0.034 14.1 0.0 10.5 11 2 0 11 11 11 4 Bacterial Ig-like domain (group 2) AMP-binding PF00501.28 EKE41409.1 - 3.3e-24 85.2 0.3 3.3e-24 85.2 0.3 2.2 2 2 0 2 2 2 1 AMP-binding enzyme DUF2569 PF10754.9 EKE41410.1 - 0.044 14.2 0.1 0.095 13.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Coatomer_E PF04733.14 EKE41411.1 - 1.8e-09 37.5 0.4 2.1e-07 30.6 0.1 2.3 2 0 0 2 2 2 2 Coatomer epsilon subunit TPR_12 PF13424.6 EKE41411.1 - 2.7e-05 24.4 2.1 31 4.9 0.1 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EKE41411.1 - 4.3e-05 23.3 16.3 1.8 8.9 1.1 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EKE41411.1 - 0.00038 20.5 6.1 0.037 14.1 0.1 3.4 2 1 1 3 3 3 2 Putative TPR-like repeat TPR_19 PF14559.6 EKE41411.1 - 0.0061 17.0 1.6 1.2 9.7 0.0 4.8 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 EKE41411.1 - 0.036 14.7 1.7 7.7 7.2 0.0 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE41411.1 - 0.063 13.5 16.8 1.7 8.9 0.0 4.9 4 1 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 EKE41411.1 - 0.07 13.4 0.5 3.2 8.2 0.2 3.5 4 0 0 4 4 4 0 PPR repeat TPR_1 PF00515.28 EKE41411.1 - 3.1 7.8 18.1 5.8 6.9 0.1 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat CPBP PF02517.16 EKE41413.1 - 0.00023 21.5 19.9 0.002 18.5 19.9 2.4 1 1 0 1 1 1 1 CPBP intramembrane metalloprotease START PF01852.19 EKE41414.1 - 0.00022 20.7 0.1 0.00035 20.0 0.0 1.4 2 0 0 2 2 2 1 START domain DUF3074 PF11274.8 EKE41414.1 - 0.014 15.3 0.1 0.035 14.1 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) RhoGEF PF00621.20 EKE41415.1 - 1.1e-25 90.9 2.7 1.1e-25 90.9 2.7 2.0 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 EKE41415.1 - 0.0008 19.9 2.8 0.0008 19.9 0.5 2.3 2 0 0 2 2 2 1 PH domain PMC2NT PF08066.12 EKE41416.1 - 0.02 15.5 1.2 0.02 15.5 1.2 2.4 2 1 0 2 2 2 0 PMC2NT (NUC016) domain CdvA PF18822.1 EKE41416.1 - 0.1 12.4 15.7 0.053 13.4 9.9 2.5 1 1 1 2 2 2 0 CdvA-like coiled-coil domain Med9 PF07544.13 EKE41416.1 - 0.24 11.5 11.8 0.033 14.3 6.4 2.3 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF948 PF06103.11 EKE41416.1 - 0.34 11.2 11.9 0.96 9.8 4.3 3.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) TMPIT PF07851.13 EKE41416.1 - 0.45 9.7 16.4 8.7 5.5 16.4 2.1 1 1 0 1 1 1 0 TMPIT-like protein XhlA PF10779.9 EKE41416.1 - 0.71 10.1 10.6 0.23 11.7 4.7 2.7 2 0 0 2 2 2 0 Haemolysin XhlA Aconitase_C PF00694.19 EKE41416.1 - 1 9.7 8.2 0.21 11.9 4.6 1.7 2 0 0 2 2 2 0 Aconitase C-terminal domain AAA PF00004.29 EKE41418.1 - 7.9e-43 146.0 1.4 5e-36 124.1 0.0 3.0 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EKE41418.1 - 4.6e-10 39.6 0.2 0.00018 21.5 0.0 3.7 2 2 1 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EKE41418.1 - 4.2e-08 33.8 0.7 0.0017 18.8 0.0 3.6 2 2 1 3 3 3 2 AAA ATPase domain AAA_7 PF12775.7 EKE41418.1 - 1.1e-07 31.5 0.1 0.015 14.8 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 EKE41418.1 - 7.3e-07 29.4 0.0 5.9e-06 26.4 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_lid_3 PF17862.1 EKE41418.1 - 8.7e-07 28.7 0.0 2.1e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 EKE41418.1 - 1.9e-05 24.1 0.0 0.11 11.7 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain TsaE PF02367.17 EKE41418.1 - 7.4e-05 22.7 0.5 0.71 9.9 0.0 3.2 2 1 1 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EKE41418.1 - 7.6e-05 22.0 0.0 0.0017 17.5 0.0 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 EKE41418.1 - 0.00025 21.4 0.1 1.6 9.1 0.0 3.3 3 0 0 3 3 3 2 RNA helicase AAA_2 PF07724.14 EKE41418.1 - 0.00027 21.1 0.2 0.0022 18.1 0.0 2.6 3 1 1 4 4 4 1 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 EKE41418.1 - 0.00055 19.7 0.2 0.047 13.4 0.0 3.2 2 2 1 3 3 3 1 Sigma-54 interaction domain Rad17 PF03215.15 EKE41418.1 - 0.001 19.0 0.5 0.07 13.0 0.0 2.9 2 1 1 3 3 3 1 Rad17 P-loop domain Mg_chelatase PF01078.21 EKE41418.1 - 0.0012 18.3 0.0 1 8.7 0.0 2.8 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EKE41418.1 - 0.0024 17.6 0.1 0.99 9.2 0.0 2.9 3 0 0 3 3 3 1 P-loop containing region of AAA domain RuvB_N PF05496.12 EKE41418.1 - 0.0035 17.1 0.1 0.64 9.8 0.0 2.8 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 EKE41418.1 - 0.016 15.7 1.0 5.1 7.6 0.0 3.2 4 0 0 4 4 3 0 ABC transporter DEAD PF00270.29 EKE41418.1 - 0.032 14.0 1.0 9.3 6.0 0.4 2.5 1 1 0 2 2 2 0 DEAD/DEAH box helicase MCM PF00493.23 EKE41418.1 - 0.035 13.2 0.0 0.15 11.1 0.0 2.0 2 0 0 2 2 2 0 MCM P-loop domain NACHT PF05729.12 EKE41418.1 - 0.043 13.7 3.3 3.1 7.7 0.0 3.2 2 1 1 3 3 3 0 NACHT domain PhoH PF02562.16 EKE41418.1 - 0.12 11.8 0.3 1.3 8.5 0.0 2.7 3 1 1 4 4 4 0 PhoH-like protein AAA_22 PF13401.6 EKE41418.1 - 0.44 10.8 6.3 7.2 6.9 0.1 4.0 2 2 1 4 4 4 0 AAA domain Adaptin_N PF01602.20 EKE41419.1 - 7.5e-98 328.4 13.6 1.1e-97 327.7 13.6 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EKE41419.1 - 1.6e-21 77.0 7.8 3.2e-18 66.3 0.6 3.2 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKE41419.1 - 1.5e-09 38.1 0.1 0.0029 17.9 0.0 5.2 2 2 3 6 6 6 5 HEAT repeats HEAT PF02985.22 EKE41419.1 - 4.6e-08 32.7 0.1 0.081 13.2 0.0 5.4 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EKE41419.1 - 0.14 12.7 0.1 13 6.5 0.0 3.8 3 1 1 4 4 4 0 HEAT-like repeat Pkinase_Tyr PF07714.17 EKE41420.1 - 3e-52 177.5 0.0 5e-52 176.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41420.1 - 5.8e-47 160.3 0.0 1.6e-46 158.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Laminin_G_3 PF13385.6 EKE41420.1 - 5.3e-07 29.9 1.8 0.0015 18.7 0.1 2.7 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily TMEM154 PF15102.6 EKE41420.1 - 9.5e-05 22.3 0.1 9.5e-05 22.3 0.1 2.5 2 0 0 2 2 2 1 TMEM154 protein family Pkinase_fungal PF17667.1 EKE41420.1 - 0.00042 19.2 0.0 0.0007 18.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase DUF4064 PF13273.6 EKE41420.1 - 0.002 18.4 0.9 0.0073 16.6 0.9 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) Stevor PF17410.2 EKE41420.1 - 0.0021 17.7 0.1 0.0048 16.5 0.1 1.6 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame Tmemb_9 PF05434.11 EKE41420.1 - 0.0059 16.5 3.2 0.0059 16.5 3.2 2.0 2 0 0 2 2 2 1 TMEM9 RIFIN PF02009.16 EKE41420.1 - 0.0064 16.4 0.1 0.0064 16.4 0.1 2.2 3 0 0 3 3 3 1 Rifin EphA2_TM PF14575.6 EKE41420.1 - 0.0064 17.3 0.4 0.014 16.2 0.4 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain DUF1080 PF06439.11 EKE41420.1 - 0.0094 16.1 0.1 4.7 7.3 0.0 2.8 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1080) DUF5385 PF17359.2 EKE41420.1 - 0.03 13.9 1.5 0.066 12.8 1.5 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Protocadherin PF08374.11 EKE41420.1 - 0.054 13.5 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Protocadherin ECSCR PF15820.5 EKE41420.1 - 0.074 12.9 4.5 0.045 13.6 0.7 2.5 3 0 0 3 3 3 0 Endothelial cell-specific chemotaxis regulator PspB PF06667.12 EKE41420.1 - 0.092 12.8 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 Phage shock protein B ASFV_J13L PF05568.11 EKE41420.1 - 8.4 6.1 10.0 0.076 12.8 0.6 2.3 3 0 0 3 3 3 0 African swine fever virus J13L protein PEP-utilisers_N PF05524.13 EKE41421.1 - 0.23 11.6 0.5 0.48 10.6 0.5 1.4 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal HhH-GPD PF00730.25 EKE41422.1 - 7.1e-16 58.6 0.0 2.1e-15 57.1 0.0 1.7 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EKE41422.1 - 2.9e-08 33.2 0.0 2.2e-07 30.4 0.0 2.4 3 0 0 3 3 3 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EKE41422.1 - 0.00046 20.7 0.2 0.0023 18.5 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain Cdd1 PF11731.8 EKE41422.1 - 0.022 15.0 0.0 0.056 13.7 0.0 1.7 1 0 0 1 1 1 0 Pathogenicity locus DUF2400 PF09674.10 EKE41422.1 - 0.04 13.9 0.0 1 9.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) HHH_8 PF14716.6 EKE41422.1 - 0.12 12.8 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain UbiA PF01040.18 EKE41423.1 - 0.0033 16.8 7.4 0.0033 16.8 7.4 1.4 2 0 0 2 2 2 1 UbiA prenyltransferase family DUF981 PF06168.11 EKE41423.1 - 0.041 13.8 9.6 0.035 14.0 8.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF981) FA_desaturase PF00487.24 EKE41423.1 - 0.054 13.3 0.2 0.082 12.7 0.2 1.3 1 0 0 1 1 1 0 Fatty acid desaturase T_cell_tran_alt PF15128.6 EKE41423.1 - 0.099 12.5 0.5 0.31 10.9 0.1 2.0 2 0 0 2 2 2 0 T-cell leukemia translocation-altered SK_channel PF03530.14 EKE41423.1 - 0.45 10.5 5.4 0.26 11.3 2.6 2.0 2 1 0 2 2 2 0 Calcium-activated SK potassium channel Oxidored_q2 PF00420.24 EKE41423.1 - 1.9 8.1 8.6 0.072 12.7 0.9 2.2 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Sigma_reg_N PF13800.6 EKE41423.1 - 5 7.5 9.6 18 5.7 0.8 3.2 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Acyltransferase PF01553.21 EKE41424.1 - 1.5e-16 60.2 0.0 2.4e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EKE41424.1 - 1.6e-16 60.2 1.5 2.3e-16 59.6 0.1 2.0 2 0 0 2 2 2 1 Acyltransferase C-terminus Pkinase PF00069.25 EKE41425.1 - 2.7e-73 246.6 0.3 3.4e-73 246.3 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41425.1 - 5.1e-37 127.6 0.1 6.5e-37 127.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE41425.1 - 1.5e-21 76.9 1.3 2.8e-21 76.0 1.3 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EKE41425.1 - 2e-09 37.2 0.1 3.4e-07 29.9 0.0 2.2 1 1 1 2 2 2 2 Kinase-like PH_11 PF15413.6 EKE41425.1 - 5.7e-07 29.9 3.6 2.4e-05 24.7 3.6 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EKE41425.1 - 5.8e-07 29.7 0.1 1.5e-06 28.4 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EKE41425.1 - 1.2e-06 28.5 0.3 3.2e-06 27.2 0.3 1.8 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EKE41425.1 - 0.00049 20.5 0.9 0.003 17.9 0.1 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain Pkinase_fungal PF17667.1 EKE41425.1 - 0.0046 15.8 0.0 0.0077 15.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EKE41425.1 - 0.039 13.6 0.2 2.4 7.7 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Phospholip_B PF04916.13 EKE41426.1 - 1.1e-120 403.7 11.2 1.4e-120 403.5 11.2 1.0 1 0 0 1 1 1 1 Phospholipase B Pkinase_Tyr PF07714.17 EKE41427.1 - 2.9e-54 184.1 0.0 3.9e-54 183.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41427.1 - 2.2e-46 158.4 0.0 4.1e-46 157.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EKE41427.1 - 2.5e-06 27.6 0.0 0.036 14.0 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Ninjurin PF04923.12 EKE41427.1 - 0.028 14.4 0.3 0.38 10.7 0.0 2.3 2 0 0 2 2 2 0 Ninjurin Ras PF00071.22 EKE41428.1 - 2.2e-47 160.7 2.4 2.5e-47 160.5 2.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41428.1 - 2.5e-31 108.4 1.6 3.7e-31 107.8 1.6 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41428.1 - 1.4e-21 76.7 1.2 1.7e-21 76.5 1.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE41428.1 - 3.4e-06 26.6 0.1 6.2e-06 25.8 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EKE41428.1 - 6e-06 25.8 0.8 7.3e-06 25.5 0.8 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE41428.1 - 0.00054 20.0 0.2 0.00054 20.0 0.2 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE41428.1 - 0.00057 19.5 2.8 0.0045 16.6 2.8 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 EKE41428.1 - 0.0025 17.4 1.0 0.0092 15.5 0.1 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region Glyco_hydro_3_C PF01915.22 EKE41428.1 - 0.014 15.3 0.4 0.14 12.0 0.4 2.0 1 1 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain DUF211 PF02680.14 EKE41428.1 - 0.082 13.1 0.3 0.23 11.6 0.3 1.8 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 XPG_N PF00752.17 EKE41429.1 - 2.8e-20 72.7 0.0 8.3e-20 71.2 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 EKE41429.1 - 4.8e-19 68.5 0.1 6.1e-18 65.0 0.1 2.7 2 0 0 2 2 2 1 XPG I-region XPG_I_2 PF12813.7 EKE41429.1 - 0.00016 21.3 0.1 0.00028 20.4 0.1 1.4 1 0 0 1 1 1 1 XPG domain containing WD40_3 PF15911.5 EKE41429.1 - 0.037 14.0 0.1 0.094 12.7 0.1 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat E_raikovi_mat PF06360.11 EKE41429.1 - 0.22 12.0 3.7 6.7 7.2 0.2 2.5 2 0 0 2 2 2 0 Euplotes raikovi mating pheromone DUF5305 PF17231.2 EKE41430.1 - 0.053 12.9 3.0 0.075 12.4 2.1 1.6 1 1 1 2 2 2 0 Family of unknown function (DUF5305) Pkinase PF00069.25 EKE41431.1 - 7e-31 107.6 0.1 9e-31 107.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41431.1 - 2.4e-15 56.5 0.0 3.7e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EKE41431.1 - 0.00013 22.0 0.0 0.00022 21.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EKE41431.1 - 0.00024 20.5 1.1 0.00064 19.1 0.1 2.1 3 0 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 EKE41431.1 - 0.00062 18.7 0.1 0.0016 17.3 0.2 1.6 2 0 0 2 2 2 1 Fungal protein kinase PIP49_C PF12260.8 EKE41431.1 - 0.0011 18.7 0.1 0.0022 17.7 0.1 1.5 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 DUF948 PF06103.11 EKE41432.1 - 0.021 15.1 0.3 0.6 10.4 0.0 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Ras PF00071.22 EKE41433.1 - 2.5e-10 40.2 0.1 2.7e-10 40.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41433.1 - 3.4e-05 24.0 0.0 3.6e-05 24.0 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LapA_dom PF06305.11 EKE41434.1 - 0.049 13.4 0.0 0.049 13.4 0.0 1.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain RFX_DNA_binding PF02257.15 EKE41434.1 - 0.18 12.4 2.6 0.54 10.9 0.2 2.5 2 1 1 3 3 3 0 RFX DNA-binding domain PSI PF01437.25 EKE41434.1 - 3.3 8.3 11.9 24 5.5 11.9 2.1 1 1 0 1 1 1 0 Plexin repeat zf-C2H2_jaz PF12171.8 EKE41435.1 - 1.1e-07 31.9 2.9 2.7e-07 30.7 2.9 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EKE41435.1 - 0.0002 21.7 2.2 0.00038 20.7 2.2 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF629 PF04780.12 EKE41435.1 - 0.0089 14.6 0.1 0.011 14.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF629) LRR_5 PF13306.6 EKE41436.1 - 4.1e-86 285.4 46.6 9.3e-28 96.7 12.3 4.3 2 2 2 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE41436.1 - 1.6e-16 59.8 4.1 0.013 15.3 0.2 7.8 2 2 6 9 9 9 7 Leucine rich repeat AgrD PF05931.11 EKE41436.1 - 0.76 9.9 4.0 3.6 7.7 1.0 2.9 2 0 0 2 2 2 0 Staphylococcal AgrD protein zf-Tim10_DDP PF02953.15 EKE41436.1 - 2.1 8.0 7.4 0.72 9.5 1.0 3.2 2 1 0 3 3 3 0 Tim10/DDP family zinc finger BAG6 PF12057.8 EKE41437.1 - 0.0013 18.4 0.3 0.15 11.8 0.0 2.2 1 1 1 2 2 2 2 BCL2-associated athanogene 6 DUF1154 PF06631.11 EKE41437.1 - 9.6 6.3 8.3 1.7 8.7 0.5 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1154) DUF5442 PF17514.2 EKE41438.1 - 0.022 14.9 1.0 0.29 11.4 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5442) adh_short PF00106.25 EKE41439.1 - 1.1e-40 139.2 0.1 1.4e-40 138.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EKE41439.1 - 1.8e-24 86.6 0.0 2.3e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EKE41439.1 - 1.7e-07 31.4 0.0 2.9e-07 30.6 0.0 1.3 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EKE41439.1 - 2.6e-05 23.5 0.1 3.7e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EKE41439.1 - 8.2e-05 22.2 0.1 0.00056 19.4 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 EKE41439.1 - 0.0025 18.3 0.5 0.0044 17.6 0.5 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EKE41439.1 - 0.0049 17.1 0.1 0.011 16.0 0.1 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 EKE41439.1 - 0.012 15.1 0.2 0.024 14.0 0.0 1.6 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EKE41439.1 - 0.014 15.3 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding PepSY_TM PF03929.16 EKE41439.1 - 0.018 14.8 0.2 0.027 14.2 0.2 1.2 1 0 0 1 1 1 0 PepSY-associated TM region 3HCDH_N PF02737.18 EKE41439.1 - 0.018 14.9 0.1 0.028 14.3 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ResIII PF04851.15 EKE41439.1 - 0.038 14.0 0.1 0.066 13.2 0.1 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NmrA PF05368.13 EKE41439.1 - 0.053 13.1 0.0 0.081 12.5 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Adenylsucc_synt PF00709.21 EKE41439.1 - 0.17 10.8 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Adenylosuccinate synthetase Got1 PF04178.12 EKE41440.1 - 2.4e-07 31.2 16.2 4.4e-07 30.3 16.3 1.5 1 1 0 1 1 1 1 Got1/Sft2-like family Peptidase_M48_N PF16491.5 EKE41440.1 - 0.017 15.0 0.5 0.017 15.0 0.5 2.1 2 0 0 2 2 2 0 CAAX prenyl protease N-terminal, five membrane helices CbtA PF09490.10 EKE41440.1 - 0.033 13.9 0.4 0.048 13.4 0.4 1.2 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) DUF3021 PF11457.8 EKE41440.1 - 0.11 12.8 12.7 0.17 12.2 12.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DUF5409 PF17421.2 EKE41440.1 - 0.77 10.5 7.1 0.23 12.2 1.7 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5409) DUF2407_C PF13373.6 EKE41441.1 - 0.049 13.8 0.6 0.049 13.8 0.6 1.6 2 0 0 2 2 2 0 DUF2407 C-terminal domain DUF775 PF05603.12 EKE41441.1 - 0.064 12.8 5.5 0.028 13.9 2.6 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF775) DUF2207 PF09972.9 EKE41441.1 - 0.19 10.4 2.3 0.23 10.2 0.6 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3671 PF12420.8 EKE41441.1 - 1.3 9.1 5.7 18 5.5 0.0 3.3 2 1 1 3 3 3 0 Protein of unknown function DUF3888 PF13027.6 EKE41441.1 - 2.4 8.6 8.1 0.26 11.7 3.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3888) Vma12 PF11712.8 EKE41441.1 - 3.6 7.6 9.8 0.26 11.3 1.0 2.7 3 0 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2385 PF09539.10 EKE41441.1 - 4.4 7.9 6.4 32 5.1 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF2385) DUF4407 PF14362.6 EKE41441.1 - 5.5 6.3 12.7 9 5.5 12.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-3CxxC_2 PF17180.4 EKE41441.1 - 6.8 7.5 8.1 16 6.3 1.1 2.6 2 0 0 2 2 2 0 Zinc-binding domain PMC2NT PF08066.12 EKE41441.1 - 7.3 7.4 6.9 5 7.9 0.1 3.2 3 1 0 3 3 3 0 PMC2NT (NUC016) domain KH_6 PF15985.5 EKE41442.1 - 4.2e-08 33.4 0.1 8.5e-08 32.4 0.1 1.6 1 0 0 1 1 1 1 KH domain ECR1_N PF14382.6 EKE41442.1 - 1.1e-05 25.1 0.0 2.3e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region AnfG_VnfG PF03139.15 EKE41443.1 - 0.028 14.5 2.0 0.11 12.6 0.0 2.6 2 1 0 2 2 2 0 Vanadium/alternative nitrogenase delta subunit Ku_C PF03730.14 EKE41443.1 - 0.87 10.3 10.8 32 5.3 0.1 4.1 3 1 1 4 4 4 0 Ku70/Ku80 C-terminal arm DUF5137 PF17220.3 EKE41444.1 - 0.21 12.5 8.7 0.84 10.5 2.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF5137) DUF1041 PF06292.17 EKE41445.1 - 3.1 8.2 6.5 1.5 9.3 0.5 2.9 2 2 0 2 2 2 0 Domain of Unknown Function (DUF1041) Helicase_C PF00271.31 EKE41446.1 - 3e-14 53.3 2.7 2.3e-13 50.5 0.0 3.3 3 2 1 4 4 4 1 Helicase conserved C-terminal domain HA2 PF04408.23 EKE41446.1 - 6.6e-12 45.7 0.0 1.8e-11 44.2 0.0 1.9 1 1 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 EKE41446.1 - 4.1e-09 36.4 0.7 1.5e-08 34.6 0.2 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EKE41446.1 - 0.0011 19.2 0.2 0.0064 16.8 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EKE41446.1 - 0.0021 17.6 0.1 0.037 13.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EKE41446.1 - 0.004 17.1 0.0 0.013 15.4 0.0 1.9 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 EKE41446.1 - 0.0045 17.5 3.3 0.021 15.3 0.1 3.0 2 1 0 3 3 3 1 ABC transporter ATPase PF06745.13 EKE41446.1 - 0.0066 15.8 0.1 0.087 12.2 0.0 2.6 2 0 0 2 2 2 1 KaiC AAA_14 PF13173.6 EKE41446.1 - 0.0069 16.4 1.0 0.36 10.9 1.0 2.8 1 1 0 1 1 1 1 AAA domain OB_NTP_bind PF07717.16 EKE41446.1 - 0.015 15.6 0.1 0.061 13.7 0.0 2.1 2 0 0 2 2 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_23 PF13476.6 EKE41446.1 - 0.018 15.6 0.2 0.018 15.6 0.2 2.9 2 2 0 2 2 2 0 AAA domain DUF4933 PF16287.5 EKE41446.1 - 0.023 14.1 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4933) AAA_25 PF13481.6 EKE41446.1 - 0.024 14.2 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EKE41446.1 - 0.029 13.8 0.0 0.16 11.4 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein Helicase_RecD PF05127.14 EKE41446.1 - 0.067 13.0 0.0 0.25 11.2 0.0 2.1 2 0 0 2 2 1 0 Helicase Roc PF08477.13 EKE41446.1 - 0.073 13.3 0.0 0.39 11.0 0.0 2.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA PF00004.29 EKE41446.1 - 0.091 13.2 0.8 0.39 11.1 0.1 2.5 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EKE41446.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EKE41446.1 - 0.12 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EKE41446.1 - 0.13 12.2 0.1 0.69 9.8 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 EKE41446.1 - 0.17 12.2 0.0 0.53 10.6 0.0 1.8 2 0 0 2 2 1 0 AAA ATPase domain ResIII PF04851.15 EKE41446.1 - 0.51 10.3 14.5 0.086 12.8 0.7 3.7 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit Peptidase_C1 PF00112.23 EKE41447.1 - 2.4e-70 237.0 3.7 3e-70 236.7 3.7 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE41447.1 - 1e-05 25.9 2.3 2.1e-05 24.8 2.3 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EKE41447.1 - 0.00056 18.8 0.2 0.056 12.2 0.1 2.1 2 0 0 2 2 2 2 Peptidase C1-like family AAA_23 PF13476.6 EKE41448.1 - 4.6e-16 59.9 13.9 4.6e-16 59.9 13.9 6.4 1 1 3 4 4 4 1 AAA domain SMC_N PF02463.19 EKE41448.1 - 4.3e-14 52.5 0.3 4.3e-14 52.5 0.3 3.6 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EKE41448.1 - 2.9e-13 50.3 25.9 2.9e-13 50.3 25.9 4.2 1 1 2 3 3 3 1 AAA ATPase domain AAA_21 PF13304.6 EKE41448.1 - 0.00043 20.2 0.1 0.00043 20.2 0.1 4.3 3 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKE41448.1 - 0.00097 18.8 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF3467 PF11950.8 EKE41448.1 - 0.064 13.5 1.2 16 5.8 0.1 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3467) SbcCD_C PF13558.6 EKE41448.1 - 0.076 13.3 0.0 1.6 9.0 0.0 2.5 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 EKE41448.1 - 0.21 12.1 0.0 0.21 12.1 0.0 5.8 3 2 0 3 3 3 0 ABC transporter TLD PF07534.16 EKE41449.1 - 0.00039 20.6 1.0 0.0011 19.2 1.0 1.8 1 0 0 1 1 1 1 TLD Asp-B-Hydro_N PF05279.11 EKE41449.1 - 1.4 8.9 34.9 2.4 8.2 34.9 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region MMR1 PF08505.10 EKE41449.1 - 3.8 7.7 26.3 6.5 7.0 26.3 1.4 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein NPR3 PF03666.13 EKE41449.1 - 4.1 6.1 22.5 6.9 5.3 22.5 1.5 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 EKE41449.1 - 7.1 6.6 14.2 11 6.0 14.2 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 EKE41449.1 - 7.4 5.2 22.8 11 4.6 22.8 1.3 1 0 0 1 1 1 0 Presenilin tRNA-synt_1 PF00133.22 EKE41450.1 - 2.3e-209 696.6 1.5 2.3e-209 696.6 1.5 3.1 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EKE41450.1 - 1.9e-39 135.1 0.1 1.9e-39 135.1 0.1 2.4 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EKE41450.1 - 1.2e-16 60.5 4.4 3.4e-08 32.7 0.2 5.3 3 2 1 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EKE41450.1 - 2.3e-07 30.5 0.0 2.3e-07 30.5 0.0 2.9 2 1 1 3 3 3 1 Leucyl-tRNA synthetase, Domain 2 MRP-S35 PF10246.9 EKE41450.1 - 0.016 15.2 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein MRP-S35 CCDC24 PF15669.5 EKE41450.1 - 0.027 14.3 1.6 0.063 13.1 1.6 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family tRNA-synt_1e PF01406.19 EKE41450.1 - 0.4 10.0 0.0 0.4 10.0 0.0 3.3 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain TPR_2 PF07719.17 EKE41451.1 - 2.4e-11 42.8 25.2 0.14 12.4 0.0 10.3 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_12 PF13424.6 EKE41451.1 - 5.2e-08 33.1 8.1 0.063 13.6 0.0 6.4 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EKE41451.1 - 2.1e-06 27.3 36.0 0.025 14.4 0.5 9.2 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_17 PF13431.6 EKE41451.1 - 3.5e-06 27.0 4.5 5.2e-05 23.3 0.0 5.1 6 2 0 6 6 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EKE41451.1 - 3.2e-05 23.8 25.5 0.0012 18.9 0.0 9.2 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_19 PF14559.6 EKE41451.1 - 0.00013 22.4 10.6 12 6.4 0.0 7.9 7 2 2 10 10 10 0 Tetratricopeptide repeat TPR_9 PF13371.6 EKE41451.1 - 0.00046 20.3 0.0 1.2 9.4 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EKE41451.1 - 0.00081 20.0 0.0 6.7 7.5 0.0 3.7 3 1 2 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EKE41451.1 - 0.0028 17.6 5.2 0.51 10.5 0.0 5.5 5 1 0 5 5 5 1 Tetratricopeptide repeat DUF4011 PF13195.6 EKE41451.1 - 0.019 14.9 0.5 0.048 13.6 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) TPR_14 PF13428.6 EKE41451.1 - 0.031 15.1 0.9 2.8 9.0 0.1 4.5 5 2 1 6 6 4 0 Tetratricopeptide repeat MLANA PF14991.6 EKE41451.1 - 0.18 12.1 1.0 4 7.8 0.0 3.1 3 0 0 3 3 3 0 Protein melan-A TPR_10 PF13374.6 EKE41451.1 - 0.64 10.0 7.1 3 7.8 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_15 PF13429.6 EKE41451.1 - 1.1 8.4 3.8 9.7 5.3 0.3 3.5 3 2 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE41451.1 - 1.2 9.4 20.4 1.6 9.0 0.0 6.8 4 3 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EKE41451.1 - 2.8 8.8 13.0 7.9 7.4 0.0 6.7 9 0 0 9 9 7 0 Tetratricopeptide repeat Peptidase_C1 PF00112.23 EKE41452.1 - 1.1e-65 221.8 6.0 1.1e-65 221.8 6.0 1.5 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE41452.1 - 4.9e-09 36.5 0.4 1.2e-08 35.2 0.4 1.7 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EKE41452.1 - 5.1e-05 22.2 3.0 0.064 12.0 0.1 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Aminotran_1_2 PF00155.21 EKE41453.1 - 5.4e-42 144.3 0.0 7.1e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EKE41453.1 - 0.0084 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Hexapep_2 PF14602.6 EKE41455.1 - 8.4e-13 47.8 20.7 3.2e-08 33.2 1.1 3.1 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 EKE41455.1 - 3.5e-12 45.5 25.5 8.4e-10 38.0 2.7 4.3 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 EKE41455.1 - 0.0021 18.3 0.0 0.0031 17.7 0.0 1.2 1 0 0 1 1 1 1 Maltose acetyltransferase IBR PF01485.21 EKE41456.1 - 1.2e-15 57.5 24.6 1.4e-11 44.4 2.4 4.5 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 EKE41456.1 - 2.3e-05 24.2 0.9 2.3e-05 24.2 0.9 4.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EKE41456.1 - 2.5e-05 24.0 1.5 2.5e-05 24.0 1.5 4.8 4 1 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE41456.1 - 8.9e-05 22.4 1.0 8.9e-05 22.4 1.0 3.9 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 EKE41456.1 - 0.00029 20.7 1.4 0.00029 20.7 1.4 4.5 4 1 0 4 4 4 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EKE41456.1 - 0.00035 20.4 4.5 0.00035 20.4 4.5 4.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE41456.1 - 0.013 15.3 1.6 0.013 15.3 1.6 4.0 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 Copine PF07002.16 EKE41457.1 - 9.1e-56 188.7 0.0 1.1e-55 188.4 0.0 1.1 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EKE41457.1 - 3e-07 30.8 0.0 4.5e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EKE41457.1 - 0.026 14.8 0.1 0.058 13.6 0.0 1.6 2 0 0 2 2 2 0 von Willebrand factor type A domain RisS_PPD PF16524.5 EKE41458.1 - 0.98 9.7 4.7 16 5.8 0.1 2.4 1 1 1 2 2 2 0 Periplasmic domain of Sensor histidine kinase RisS VWA PF00092.28 EKE41459.1 - 1.6e-05 25.2 0.2 2.7e-05 24.5 0.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EKE41459.1 - 2.5e-05 23.8 0.0 5.9e-05 22.6 0.0 1.5 1 1 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 EKE41459.1 - 0.00014 21.8 0.0 0.00021 21.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF3876 PF12992.7 EKE41459.1 - 0.076 13.1 0.0 0.34 11.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3876) ACDC PF14733.6 EKE41460.1 - 0.0012 19.1 0.7 0.0015 18.8 0.7 1.2 1 0 0 1 1 1 1 AP2-coincident C-terminal ELFV_dehydrog PF00208.21 EKE41461.1 - 7.5e-35 120.8 0.2 1.7e-34 119.7 0.2 1.6 1 1 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EKE41461.1 - 9.7e-18 63.2 0.1 1.6e-11 42.5 0.0 3.2 3 0 0 3 3 3 3 Bacterial NAD-glutamate dehydrogenase DUF2935 PF11155.8 EKE41461.1 - 6.1 7.2 6.4 12 6.2 1.1 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) ETRAMP PF09716.10 EKE41461.1 - 7.1 6.8 6.3 0.95 9.6 0.3 2.6 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Pkinase PF00069.25 EKE41462.1 - 2.3e-38 132.1 1.4 3.5e-38 131.5 1.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41462.1 - 2.6e-24 85.9 0.1 3.7e-24 85.4 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EKE41462.1 - 1.7e-06 28.3 0.5 6.5e-06 26.4 0.2 2.1 2 0 0 2 2 2 1 FHA domain Kinase-like PF14531.6 EKE41462.1 - 1e-05 25.0 0.0 1.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like TEX12 PF15219.6 EKE41463.1 - 0.69 10.3 9.1 4.4 7.7 0.2 3.6 1 1 2 3 3 3 0 Testis-expressed 12 DUF1515 PF07439.11 EKE41463.1 - 1.5 8.9 3.8 1.6 8.8 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DUF1664 PF07889.12 EKE41463.1 - 7 6.7 17.4 8.6 6.4 6.4 3.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF603 PF04645.12 EKE41464.1 - 0.021 14.5 0.1 0.03 14.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF603 DUF3053 PF11254.8 EKE41464.1 - 0.089 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) Pkinase PF00069.25 EKE41465.1 - 3.5e-53 180.6 1.2 8.9e-53 179.3 1.2 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41465.1 - 9e-19 67.8 0.1 1.4e-18 67.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE41465.1 - 0.0022 17.4 0.0 0.0036 16.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PIP49_C PF12260.8 EKE41465.1 - 0.0066 16.1 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Choline_kinase PF01633.20 EKE41465.1 - 0.0086 15.7 0.3 0.025 14.2 0.3 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EKE41465.1 - 0.0097 15.5 1.0 0.017 14.8 0.0 1.9 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EKE41465.1 - 0.02 14.8 0.0 0.032 14.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Cadherin_C_2 PF16492.5 EKE41466.1 - 0.036 14.8 5.5 0.19 12.5 0.8 2.7 2 1 1 3 3 3 0 Cadherin cytoplasmic C-terminal DUF5325 PF17259.2 EKE41466.1 - 0.036 13.9 0.9 0.036 13.9 0.9 2.5 3 1 0 3 3 3 0 Family of unknown function (DUF5325) MARVEL PF01284.23 EKE41466.1 - 0.087 12.8 7.9 0.31 11.1 6.7 2.2 1 1 0 1 1 1 0 Membrane-associating domain DUF4220 PF13968.6 EKE41466.1 - 1.3 8.3 4.2 1.5 8.1 3.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4220) Wzy_C PF04932.15 EKE41466.1 - 1.5 8.4 6.6 1.4 8.5 4.3 2.0 2 1 0 2 2 2 0 O-Antigen ligase NPL PF17800.1 EKE41468.1 - 2.6e-16 60.1 0.1 2.6e-16 60.1 0.1 1.9 2 1 0 2 2 2 1 Nucleoplasmin-like domain Cas9_PI2 PF18070.1 EKE41468.1 - 1.3 9.8 3.5 61 4.5 5.0 2.9 3 1 0 3 3 3 0 CRISPR-Cas9 PI domain Rho_GDI PF02115.17 EKE41470.1 - 2.3e-36 125.4 0.2 2.6e-36 125.2 0.2 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor PH_18 PF18469.1 EKE41470.1 - 0.087 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain BRCT_2 PF16589.5 EKE41471.1 - 2.4e-16 59.9 1.8 4.7e-10 39.7 0.2 2.3 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EKE41471.1 - 8.3e-15 54.9 0.7 1.3e-07 31.9 0.1 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EKE41471.1 - 1.2e-12 47.9 0.1 3.7e-12 46.3 0.0 1.8 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 EKE41471.1 - 7.6e-08 32.2 0.0 0.00031 20.6 0.0 2.4 2 0 0 2 2 2 2 twin BRCT domain BRCT_3 PF18428.1 EKE41471.1 - 0.023 14.8 0.0 0.82 9.8 0.0 2.3 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain DUF3185 PF11381.8 EKE41471.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) NIBRIN_BRCT_II PF16508.5 EKE41471.1 - 0.14 12.5 0.0 0.31 11.4 0.0 1.6 1 0 0 1 1 1 0 Second BRCT domain on Nijmegen syndrome breakage protein Arm PF00514.23 EKE41472.1 - 0.0046 17.0 2.3 1.6 8.9 0.0 4.5 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat TAXi_C PF14541.6 EKE41472.1 - 0.1 12.4 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal HTH_Tnp_1 PF01527.20 EKE41473.1 - 0.03 14.6 0.0 8 6.9 0.0 2.2 2 0 0 2 2 2 0 Transposase FGFR3_TM PF18123.1 EKE41476.1 - 2.2 7.9 7.7 5.1 6.7 7.7 1.6 1 0 0 1 1 1 0 Fibroblast growth factor receptor 3 transmembrane domain SNF2_N PF00176.23 EKE41477.1 - 4.7e-59 199.9 0.3 1.5e-58 198.2 0.0 1.9 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE41477.1 - 1e-22 80.5 0.0 8.4e-22 77.6 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE41477.1 - 2.1e-05 24.6 0.0 2.1e-05 24.6 0.0 3.4 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit DNA_pol3_chi PF04364.13 EKE41477.1 - 0.076 13.2 0.0 0.23 11.6 0.0 1.8 1 0 0 1 1 1 0 DNA polymerase III chi subunit, HolC Clathrin PF00637.20 EKE41478.1 - 3.2e-145 477.7 66.5 6.1e-29 100.7 7.2 8.7 8 1 1 9 9 9 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EKE41478.1 - 1.4e-23 82.6 0.2 1.4e-23 82.6 0.2 3.0 3 0 0 3 3 3 1 Clathrin-H-link Clathrin_propel PF01394.20 EKE41478.1 - 1.8e-08 34.3 0.3 0.00016 21.8 0.0 4.1 3 0 0 3 3 3 2 Clathrin propeller repeat TPR_14 PF13428.6 EKE41478.1 - 9e-08 32.3 0.5 25 6.0 0.0 9.2 10 0 0 10 10 10 0 Tetratricopeptide repeat Clathrin-link PF09268.10 EKE41478.1 - 0.0038 16.5 0.0 0.0092 15.3 0.0 1.7 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Vps39_1 PF10366.9 EKE41478.1 - 0.015 15.6 32.4 0.85 9.9 1.2 9.1 7 2 0 9 9 9 0 Vacuolar sorting protein 39 domain 1 TPR_6 PF13174.6 EKE41478.1 - 0.027 15.1 3.3 42 5.1 0.1 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EKE41478.1 - 0.061 13.4 10.0 9.4 6.5 0.0 6.5 8 0 0 8 8 8 0 Tetratricopeptide repeat DUF5049 PF16468.5 EKE41478.1 - 0.23 11.4 1.7 5.8 6.9 0.0 4.0 5 0 0 5 5 5 0 Domain of unknown function (DUF5049) ANAPC3 PF12895.7 EKE41478.1 - 0.36 11.1 10.2 2.6 8.3 1.9 5.2 5 1 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Helicase_C PF00271.31 EKE41479.1 - 1.8e-17 63.6 0.3 1.2e-16 61.1 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HA2 PF04408.23 EKE41479.1 - 8.2e-14 51.8 0.0 8.2e-14 51.8 0.0 4.0 3 1 0 3 3 3 1 Helicase associated domain (HA2) DEAD PF00270.29 EKE41479.1 - 9.5e-12 45.0 0.1 3.3e-11 43.3 0.1 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 EKE41479.1 - 1.1e-09 38.5 0.0 2.8e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_19 PF13245.6 EKE41479.1 - 0.00018 21.9 0.0 0.00059 20.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EKE41479.1 - 0.00024 21.4 0.7 0.00024 21.4 0.7 3.2 3 1 0 3 3 3 1 AAA domain T2SSE PF00437.20 EKE41479.1 - 0.0068 15.5 0.2 0.019 14.0 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.6 EKE41479.1 - 0.0077 16.8 1.2 0.0077 16.8 1.2 5.5 2 1 2 4 4 4 1 AAA domain AAA_30 PF13604.6 EKE41479.1 - 0.02 14.6 0.0 0.05 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Peptidase_C1 PF00112.23 EKE41480.1 - 2.5e-34 119.3 5.5 5.4e-34 118.2 5.5 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE41480.1 - 2.3e-12 47.2 0.8 6.1e-12 45.8 0.8 1.8 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) RasGEF PF00617.19 EKE41481.1 - 1.3e-38 133.0 7.3 2.9e-38 131.8 7.3 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE41481.1 - 0.00026 21.2 0.2 0.00026 21.2 0.2 4.1 5 1 0 5 5 5 1 RasGEF N-terminal motif Brix PF04427.18 EKE41482.1 - 5e-30 105.0 0.4 6.4e-30 104.7 0.4 1.1 1 0 0 1 1 1 1 Brix domain Cnd2 PF05786.14 EKE41483.1 - 1.4e-18 67.0 7.6 1.8e-18 66.6 7.6 1.2 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EKE41483.1 - 0.0017 18.5 1.2 0.0017 18.5 1.2 2.1 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DUF2303 PF10065.9 EKE41483.1 - 0.029 13.5 0.0 0.063 12.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2303) zf-DBF PF07535.12 EKE41483.1 - 5.9 7.1 7.7 3.2 7.9 3.3 2.4 2 0 0 2 2 2 0 DBF zinc finger OCD_Mu_crystall PF02423.15 EKE41484.1 - 4.6e-33 114.5 0.0 5.7e-33 114.2 0.0 1.0 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Ycf70 PF17382.2 EKE41485.1 - 0.035 14.5 0.2 0.14 12.6 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized Ycf70-like TMEM154 PF15102.6 EKE41485.1 - 0.059 13.3 0.1 0.059 13.3 0.1 2.1 2 0 0 2 2 2 0 TMEM154 protein family DUF4366 PF14283.6 EKE41485.1 - 0.06 13.4 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Orf78 PF06024.12 EKE41485.1 - 0.086 13.1 1.1 0.17 12.2 0.3 2.0 2 0 0 2 2 2 0 Orf78 (ac78) DUF3290 PF11694.8 EKE41485.1 - 0.089 12.8 0.3 0.089 12.8 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) MSP7_C PF12948.7 EKE41486.1 - 0.036 14.7 1.7 0.062 14.0 0.2 2.1 2 0 0 2 2 2 0 MSP7-like protein C-terminal domain Glyco_hydro_3 PF00933.21 EKE41488.1 - 3.1e-40 138.5 0.0 9.4e-40 136.9 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EKE41488.1 - 2.7e-34 118.9 0.0 7.4e-34 117.5 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EKE41488.1 - 4.8e-16 58.6 0.0 1.2e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain TLD PF07534.16 EKE41489.1 - 9.4e-05 22.7 1.6 0.00011 22.4 1.6 1.1 1 0 0 1 1 1 1 TLD Laminin_II PF06009.12 EKE41490.1 - 0.017 15.1 0.1 0.027 14.5 0.1 1.3 1 0 0 1 1 1 0 Laminin Domain II DegQ PF08181.11 EKE41490.1 - 0.018 15.1 1.1 0.049 13.7 1.1 1.8 1 0 0 1 1 1 0 DegQ (SacQ) family OEP PF02321.18 EKE41490.1 - 0.023 14.5 0.6 0.026 14.3 0.6 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein HrcA PF01628.21 EKE41490.1 - 0.052 13.5 0.4 0.1 12.5 0.4 1.6 1 1 0 1 1 1 0 HrcA protein C terminal domain NDUF_B6 PF09782.9 EKE41490.1 - 0.11 12.7 0.6 0.15 12.2 0.5 1.3 1 1 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit TBCC PF07986.12 EKE41491.1 - 0.047 13.4 1.5 2.7 7.7 0.0 2.6 2 0 0 2 2 2 0 Tubulin binding cofactor C CoaE PF01121.20 EKE41492.1 - 1.6e-34 119.1 0.1 1.9e-34 118.9 0.1 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 EKE41492.1 - 0.004 17.7 2.4 0.017 15.7 2.3 2.1 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 EKE41492.1 - 0.025 14.7 0.1 0.045 13.9 0.1 1.5 1 1 0 1 1 1 0 Cytidylate kinase-like family ABC_tran PF00005.27 EKE41492.1 - 0.037 14.5 2.4 0.16 12.5 0.0 2.1 2 0 0 2 2 2 0 ABC transporter BORCS6 PF10157.9 EKE41492.1 - 0.056 13.7 0.4 0.11 12.8 0.4 1.4 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 MMR_HSR1 PF01926.23 EKE41492.1 - 0.062 13.4 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 EKE41492.1 - 0.068 13.3 0.1 0.21 11.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EKE41492.1 - 0.08 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Vps51 PF08700.11 EKE41493.1 - 0.00024 21.1 0.9 0.00024 21.1 0.9 3.6 5 0 0 5 5 5 1 Vps51/Vps67 DUF3052 PF11253.8 EKE41493.1 - 0.041 13.8 0.2 0.16 11.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3052) Cyanate_lyase PF02560.14 EKE41493.1 - 0.11 12.4 0.7 1.4 8.9 0.0 2.8 3 0 0 3 3 3 0 Cyanate lyase C-terminal domain Synaptonemal_3 PF15191.6 EKE41493.1 - 0.3 10.9 5.4 7.8 6.3 0.0 3.8 3 0 0 3 3 3 0 Synaptonemal complex central element protein 3 EI24 PF07264.11 EKE41494.1 - 0.0013 19.0 14.1 0.21 11.8 0.4 3.2 2 1 0 2 2 2 2 Etoposide-induced protein 2.4 (EI24) DUF5362 PF17319.2 EKE41494.1 - 0.24 11.3 0.0 0.24 11.3 0.0 3.6 4 0 0 4 4 4 0 Family of unknown function (DUF5362) DIL PF01843.19 EKE41495.1 - 2.3e-08 34.3 0.2 6.6e-08 32.8 0.2 1.8 1 0 0 1 1 1 1 DIL domain NT-C2 PF10358.9 EKE41495.1 - 4.3e-06 26.5 0.7 1.3e-05 25.0 0.7 1.9 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins DUF1712 PF08217.11 EKE41496.1 - 4.1e-09 35.5 2.8 8.1e-09 34.5 2.8 1.6 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) Acyltransf_C PF16076.5 EKE41498.1 - 1.5e-17 63.4 0.6 4.4e-17 61.9 0.6 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 EKE41498.1 - 3.2e-14 52.7 0.0 4.8e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase TLD PF07534.16 EKE41499.1 - 1.3e-05 25.4 0.2 2.5e-05 24.5 0.2 1.5 1 0 0 1 1 1 1 TLD PfUIS3 PF11567.8 EKE41499.1 - 0.027 14.8 2.6 0.031 14.6 1.0 1.9 2 0 0 2 2 2 0 Plasmodium falciparum UIS3 membrane protein DUF5487 PF17589.2 EKE41499.1 - 0.041 14.1 0.9 0.34 11.2 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5487) OmpH PF03938.14 EKE41499.1 - 0.086 13.2 3.7 0.27 11.6 2.4 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Rap_GAP PF02145.15 EKE41500.1 - 3.8e-49 166.8 0.0 1.6e-48 164.8 0.0 2.1 2 0 0 2 2 2 1 Rap/ran-GAP Herpes_UL92 PF03048.14 EKE41500.1 - 0.00091 19.1 6.8 0.15 11.9 0.1 3.4 3 0 0 3 3 3 2 UL92 family FidL_like PF15941.5 EKE41500.1 - 0.00094 19.6 0.2 0.2 12.1 0.2 3.2 2 0 0 2 2 2 1 FidL-like putative membrane protein DnaJ PF00226.31 EKE41501.1 - 0.00039 20.5 0.0 0.00098 19.2 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain PNP_UDP_1 PF01048.20 EKE41502.1 - 2.9e-39 134.7 0.1 3.2e-39 134.6 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily DUF3577 PF12101.8 EKE41502.1 - 0.035 13.9 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3577) SH3_14 PF18343.1 EKE41502.1 - 0.15 12.1 0.0 0.48 10.5 0.0 1.7 2 0 0 2 2 2 0 Dda helicase SH3 domain RRM_1 PF00076.22 EKE41504.1 - 1.6e-18 66.3 2.7 9.9e-11 41.3 0.2 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EKE41504.1 - 7.2e-09 35.3 0.0 0.00011 21.8 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EKE41504.1 - 4.5e-06 26.4 0.1 0.068 13.0 0.0 2.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif GNAT_acetyltran PF12746.7 EKE41504.1 - 0.021 14.4 0.1 0.041 13.4 0.1 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase RhoGEF PF00621.20 EKE41505.1 - 1.5e-17 64.4 17.1 3.3e-17 63.3 16.6 1.9 1 1 0 1 1 1 1 RhoGEF domain Neuroparsin PF07327.11 EKE41505.1 - 0.044 14.2 0.0 0.085 13.3 0.0 1.4 1 0 0 1 1 1 0 Neuroparsin DUF2533 PF10752.9 EKE41505.1 - 0.65 10.5 9.7 1.6 9.2 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2533) CTP_transf_like PF01467.26 EKE41506.1 - 4.9e-24 85.2 0.1 5.9e-24 84.9 0.1 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like STELLO PF03385.17 EKE41506.1 - 0.053 12.3 6.4 4.7 5.9 0.2 3.0 2 1 1 3 3 3 0 STELLO glycosyltransferases UCH PF00443.29 EKE41507.1 - 1.5e-24 86.9 5.8 1.5e-24 86.9 5.8 2.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE41507.1 - 0.00058 19.6 23.3 0.0012 18.5 8.1 3.4 2 1 1 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase CpXC PF14353.6 EKE41507.1 - 0.024 14.7 0.1 0.066 13.3 0.1 1.8 1 0 0 1 1 1 0 CpXC protein UPF0242 PF06785.11 EKE41508.1 - 0.00095 19.3 6.7 0.0012 19.0 6.7 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Geminin PF07412.12 EKE41508.1 - 0.002 17.9 6.2 0.0027 17.5 6.2 1.3 1 0 0 1 1 1 1 Geminin FGAR-AT_linker PF18072.1 EKE41508.1 - 0.0033 17.9 0.5 2.4 8.7 0.3 2.5 2 0 0 2 2 2 2 Formylglycinamide ribonucleotide amidotransferase linker domain DUF4201 PF13870.6 EKE41508.1 - 0.004 16.9 7.3 0.0052 16.5 7.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) CENP-F_leu_zip PF10473.9 EKE41508.1 - 0.013 15.5 9.7 0.021 14.8 9.7 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TLE_N PF03920.15 EKE41508.1 - 0.014 15.5 5.4 0.014 15.5 5.4 1.5 1 1 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain ZapB PF06005.12 EKE41508.1 - 0.023 15.1 8.0 0.039 14.4 8.0 1.4 1 0 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.15 EKE41508.1 - 0.028 14.2 2.8 0.048 13.4 2.8 1.5 1 0 0 1 1 1 0 Septum formation initiator Cep57_CLD_2 PF14197.6 EKE41508.1 - 0.031 14.4 3.4 0.048 13.8 3.4 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 GTP_EFTU PF00009.27 EKE41508.1 - 0.055 13.0 0.6 0.058 12.9 0.6 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Jacalin PF01419.17 EKE41508.1 - 0.059 13.3 0.5 0.085 12.8 0.3 1.5 1 1 0 1 1 1 0 Jacalin-like lectin domain DUF641 PF04859.12 EKE41508.1 - 0.091 13.1 5.0 0.13 12.6 5.0 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Ax_dynein_light PF10211.9 EKE41508.1 - 0.11 12.5 11.3 0.14 12.0 11.3 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain HIP1_clath_bdg PF16515.5 EKE41508.1 - 0.11 13.1 7.7 0.15 12.7 7.7 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ERp29 PF07749.12 EKE41508.1 - 0.16 12.9 5.1 0.11 13.4 3.3 1.7 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain OmpH PF03938.14 EKE41508.1 - 0.71 10.2 9.1 0.97 9.8 9.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) UPF0183 PF03676.14 EKE41509.1 - 1.8e-28 99.9 12.2 1.7e-18 67.1 7.4 2.6 1 1 0 2 2 2 2 Uncharacterised protein family (UPF0183) Pkinase PF00069.25 EKE41510.1 - 1.8e-62 211.1 0.0 3.5e-62 210.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41510.1 - 3.8e-34 118.2 0.0 7.7e-34 117.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PX PF00787.24 EKE41510.1 - 7.2e-17 61.4 0.3 2.6e-16 59.6 0.3 2.0 1 0 0 1 1 1 1 PX domain PH PF00169.29 EKE41510.1 - 1.1e-08 35.5 0.0 3.4e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 PH domain APH PF01636.23 EKE41510.1 - 1.1e-05 25.5 0.0 0.018 15.0 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EKE41510.1 - 0.00016 21.1 0.0 0.00029 20.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Glyco_hydr_30_2 PF14587.6 EKE41510.1 - 0.028 14.0 0.1 0.058 13.0 0.1 1.4 1 0 0 1 1 1 0 O-Glycosyl hydrolase family 30 DNApol3-delta_C PF09115.10 EKE41510.1 - 0.16 12.5 3.4 1.4 9.5 0.0 3.5 3 1 1 4 4 4 0 DNA polymerase III, delta subunit, C terminal HTH_3 PF01381.22 EKE41511.1 - 2.9e-17 62.5 0.7 4.4e-17 61.9 0.7 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EKE41511.1 - 1.1e-08 35.3 0.0 2.2e-08 34.3 0.0 1.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 EKE41511.1 - 3.2e-06 27.1 0.5 7.7e-06 25.8 0.3 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_38 PF13936.6 EKE41511.1 - 0.0055 16.4 0.1 0.013 15.3 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 EKE41511.1 - 0.012 16.0 0.0 0.021 15.3 0.0 1.4 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain HTH_37 PF13744.6 EKE41511.1 - 0.014 15.3 0.1 0.022 14.7 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MqsA_antitoxin PF15731.5 EKE41511.1 - 0.015 15.4 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA DUF1690 PF07956.11 EKE41511.1 - 0.13 12.7 4.2 0.28 11.6 3.9 1.6 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) TRAP-gamma PF07074.12 EKE41511.1 - 0.15 11.6 0.2 0.21 11.1 0.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) PHTB1_N PF14727.6 EKE41512.1 - 0.0011 18.4 0.5 0.54 9.5 0.2 2.3 2 0 0 2 2 2 2 PTHB1 N-terminus WD40 PF00400.32 EKE41512.1 - 0.019 15.8 0.0 5.4 8.1 0.0 3.6 3 1 0 3 3 3 0 WD domain, G-beta repeat BBS2_Mid PF14783.6 EKE41512.1 - 0.95 9.5 7.4 2.6 8.1 0.1 3.9 5 0 0 5 5 5 0 Ciliary BBSome complex subunit 2, middle region DctQ PF04290.12 EKE41513.1 - 8.6 6.3 9.0 1.6 8.6 5.2 1.7 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component HEAT PF02985.22 EKE41514.1 - 3.7e-08 32.9 1.8 0.0037 17.4 0.1 4.7 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 EKE41514.1 - 1.6e-07 31.5 0.5 0.00012 22.2 0.0 2.9 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 WD40 PF00400.32 EKE41514.1 - 2.8e-05 24.8 0.1 0.81 10.7 0.2 5.4 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE41514.1 - 0.00041 20.6 0.1 1.5 9.1 0.0 4.1 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain V-ATPase_H_C PF11698.8 EKE41514.1 - 0.0066 16.6 0.3 4.3 7.5 0.3 2.9 1 1 1 2 2 2 2 V-ATPase subunit H HEAT_2 PF13646.6 EKE41514.1 - 0.0081 16.5 0.0 0.059 13.8 0.0 2.5 2 1 1 3 3 3 1 HEAT repeats CLASP_N PF12348.8 EKE41514.1 - 0.081 12.5 1.6 0.32 10.5 0.1 2.4 2 1 0 2 2 2 0 CLASP N terminal DUF2755 PF10954.8 EKE41514.1 - 0.12 12.3 0.0 1.6 8.7 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2755) PAP2_C PF14360.6 EKE41515.1 - 2.8e-11 43.8 13.7 1.5e-09 38.3 13.7 2.2 1 1 0 1 1 1 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EKE41515.1 - 0.0013 18.5 5.5 0.0021 17.8 5.5 1.3 1 0 0 1 1 1 1 PAP2 superfamily Ras PF00071.22 EKE41516.1 - 9.1e-18 64.4 0.2 1.5e-17 63.6 0.2 1.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EKE41516.1 - 2.2e-11 44.0 0.0 8.4e-11 42.1 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EKE41516.1 - 1.1e-10 41.5 0.0 2.1e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE41516.1 - 1.6e-07 31.4 0.1 0.0022 17.9 0.1 2.7 2 1 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 EKE41516.1 - 2.8e-07 30.1 0.4 3.5e-06 26.5 0.0 2.5 1 1 2 3 3 3 1 AIG1 family Dynamin_N PF00350.23 EKE41516.1 - 3.1e-07 30.6 2.6 4.3e-06 26.9 2.6 2.7 1 1 0 1 1 1 1 Dynamin family SRPRB PF09439.10 EKE41516.1 - 7e-06 25.6 0.2 1.2e-05 24.8 0.2 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EKE41516.1 - 4.4e-05 23.1 0.0 0.073 12.6 0.0 3.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE41516.1 - 0.00016 21.1 0.7 0.00022 20.7 0.2 1.4 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EKE41516.1 - 0.00026 20.5 0.0 0.00036 20.0 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 EKE41516.1 - 0.00052 19.6 0.0 0.00083 18.9 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.18 EKE41516.1 - 0.00072 18.9 0.0 0.0025 17.2 0.0 1.9 2 0 0 2 2 2 1 Septin AAA_15 PF13175.6 EKE41516.1 - 0.0087 15.8 2.4 0.015 15.0 2.4 1.4 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 EKE41516.1 - 0.016 15.7 0.0 0.028 14.9 0.0 1.8 1 1 0 1 1 1 0 ABC transporter DUF5424 PF17462.2 EKE41516.1 - 0.022 14.7 0.3 0.022 14.7 0.3 1.5 2 0 0 2 2 1 0 Family of unknown function (DUF5424) cobW PF02492.19 EKE41516.1 - 0.029 13.9 0.1 0.17 11.5 0.0 2.1 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CPT PF07931.12 EKE41516.1 - 0.076 12.9 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_23 PF13476.6 EKE41516.1 - 0.091 13.2 3.0 1.5 9.3 3.0 2.7 1 1 0 1 1 1 0 AAA domain RhoGEF PF00621.20 EKE41519.1 - 9.3e-25 87.9 1.1 1.4e-24 87.4 1.1 1.2 1 0 0 1 1 1 1 RhoGEF domain IQ PF00612.27 EKE41519.1 - 0.00044 19.8 0.2 0.0012 18.4 0.2 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif PH PF00169.29 EKE41519.1 - 0.02 15.4 0.1 0.041 14.4 0.1 1.6 1 0 0 1 1 1 0 PH domain Brix PF04427.18 EKE41520.1 - 8.9e-17 61.8 0.6 1.4e-16 61.1 0.6 1.3 1 0 0 1 1 1 1 Brix domain Ndufs5 PF10200.9 EKE41520.1 - 0.082 13.2 1.9 4.6 7.6 1.5 2.6 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa RNR_N PF08343.10 EKE41520.1 - 0.77 9.8 6.3 16 5.6 6.3 2.7 1 1 0 1 1 1 0 Ribonucleotide reductase N-terminal Glyco_hydro_31 PF01055.26 EKE41521.1 - 1e-85 288.6 8.9 1e-85 288.6 8.9 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EKE41521.1 - 4e-09 36.7 2.7 9.3e-09 35.5 1.3 2.6 2 0 0 2 2 2 1 Galactose mutarotase-like EF-hand_7 PF13499.6 EKE41522.1 - 1.4e-06 28.6 1.7 4.3e-05 23.9 0.6 3.1 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EKE41522.1 - 4.2e-06 25.9 1.7 0.00025 20.4 0.1 3.2 2 1 1 3 3 3 1 EF hand EF-hand_8 PF13833.6 EKE41522.1 - 7.3e-05 22.5 1.6 0.013 15.3 0.2 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EKE41522.1 - 0.00013 21.6 1.3 0.0011 18.7 0.2 2.8 2 1 1 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 EKE41522.1 - 0.0004 19.7 0.7 0.003 17.0 0.1 2.4 2 0 0 2 2 2 1 EF hand MtrA PF04208.14 EKE41522.1 - 0.029 14.0 0.4 0.073 12.7 0.1 1.7 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit A RabGAP-TBC PF00566.18 EKE41523.1 - 1.1e-07 31.8 5.1 7.4e-07 29.0 4.2 2.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 EKE41523.1 - 3.3e-06 27.6 0.0 9e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Peptidase_S30 PF01577.16 EKE41523.1 - 0.25 10.9 3.5 0.47 10.0 3.5 1.3 1 0 0 1 1 1 0 Potyvirus P1 protease TF_Zn_Ribbon PF08271.12 EKE41524.1 - 0.0093 15.5 0.4 0.0093 15.5 0.4 2.1 2 0 0 2 2 2 1 TFIIB zinc-binding A2L_zn_ribbon PF08792.10 EKE41524.1 - 0.014 15.1 2.8 0.045 13.5 2.8 1.9 1 0 0 1 1 1 0 A2L zinc ribbon domain DUF2723 PF11028.8 EKE41524.1 - 0.13 12.2 0.1 0.23 11.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2723) Trypan_glycop PF00913.19 EKE41524.1 - 2.1 7.5 12.8 0.11 11.8 1.1 2.3 2 0 0 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) HD PF01966.22 EKE41525.1 - 0.002 18.4 0.9 0.0043 17.3 0.4 1.9 1 1 1 2 2 2 1 HD domain PXT1 PF15214.6 EKE41525.1 - 0.0073 16.6 0.1 0.032 14.6 0.1 1.9 2 0 0 2 2 2 1 Peroxisomal testis-specific protein 1 MbeB_N PF04837.12 EKE41525.1 - 0.039 14.2 0.1 0.072 13.4 0.1 1.4 1 0 0 1 1 1 0 MbeB-like, N-term conserved region Ras PF00071.22 EKE41526.1 - 1.6e-18 66.8 0.1 2.2e-18 66.4 0.1 1.3 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EKE41526.1 - 1.9e-09 37.2 0.2 2.6e-09 36.8 0.2 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EKE41526.1 - 9.6e-09 35.5 0.0 1.7e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gal-bind_lectin PF00337.22 EKE41526.1 - 0.043 13.4 0.2 0.057 12.9 0.2 1.2 1 0 0 1 1 1 0 Galactoside-binding lectin CENP-M PF11111.8 EKE41526.1 - 0.048 12.8 0.0 0.066 12.4 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) DHHC PF01529.20 EKE41527.1 - 7.6e-33 113.5 20.7 7.6e-33 113.5 20.7 3.1 1 1 0 2 2 2 1 DHHC palmitoyltransferase DNA_PPF PF02916.15 EKE41528.1 - 0.5 10.8 7.7 0.68 10.4 0.2 3.2 2 1 1 3 3 3 0 DNA polymerase processivity factor RasGEF PF00617.19 EKE41529.1 - 6e-35 121.0 3.3 1.3e-34 120.0 0.5 3.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EKE41529.1 - 8.4e-06 26.0 3.8 1.7e-05 25.0 1.4 2.9 2 0 0 2 2 2 1 RasGEF N-terminal motif Importin_rep_4 PF18808.1 EKE41530.1 - 7.3e-06 26.2 0.0 3.9e-05 23.9 0.0 2.3 1 0 0 1 1 1 1 Importin repeat HEAT PF02985.22 EKE41530.1 - 0.00013 21.9 1.9 63 4.2 0.1 6.9 6 0 0 6 6 6 0 HEAT repeat HEAT_2 PF13646.6 EKE41530.1 - 0.0005 20.4 0.0 20 5.7 0.0 5.7 6 1 0 6 6 6 0 HEAT repeats Arm PF00514.23 EKE41530.1 - 0.0028 17.6 1.7 33 4.7 0.0 5.5 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat NopRA1 PF16201.5 EKE41530.1 - 0.0047 16.5 8.6 0.77 9.3 0.0 6.1 6 1 1 7 7 7 1 Nucleolar pre-ribosomal-associated protein 1 HEAT_EZ PF13513.6 EKE41530.1 - 0.0099 16.4 0.4 21 5.8 0.0 5.4 5 1 0 5 5 5 0 HEAT-like repeat V-ATPase_H_C PF11698.8 EKE41530.1 - 0.028 14.5 9.1 19 5.4 0.1 6.0 7 1 1 8 8 8 0 V-ATPase subunit H RTP1_C1 PF10363.9 EKE41530.1 - 0.029 14.5 5.6 0.26 11.5 0.0 4.6 5 1 1 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EKE41530.1 - 0.04 13.5 9.5 0.045 13.3 0.2 4.9 5 2 0 5 5 5 0 CLASP N terminal Condensin2nSMC PF12422.8 EKE41530.1 - 0.05 13.8 0.6 20 5.3 0.0 4.1 4 0 0 4 4 4 0 Condensin II non structural maintenance of chromosomes subunit B56 PF01603.20 EKE41530.1 - 0.097 11.6 0.1 0.097 11.6 0.1 4.8 4 2 1 5 5 5 0 Protein phosphatase 2A regulatory B subunit (B56 family) IBN_N PF03810.19 EKE41530.1 - 0.22 11.5 0.1 0.22 11.5 0.1 4.3 6 0 0 6 6 6 0 Importin-beta N-terminal domain DUF3361 PF11841.8 EKE41530.1 - 6.7 6.6 10.0 1.7 8.5 0.2 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF3361) OTU PF02338.19 EKE41532.1 - 0.00046 20.7 0.1 0.0022 18.5 0.0 2.1 2 0 0 2 2 2 1 OTU-like cysteine protease ubiquitin PF00240.23 EKE41532.1 - 0.0045 16.7 0.1 0.0097 15.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family ThiF PF00899.21 EKE41533.1 - 3.8e-37 127.9 0.0 5e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 EKE41533.1 - 0.00056 19.5 0.1 0.00099 18.7 0.1 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 EKE41533.1 - 0.0012 19.0 0.4 0.0033 17.7 0.4 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ELFV_dehydrog PF00208.21 EKE41533.1 - 0.0042 16.8 0.0 0.0064 16.3 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Shikimate_DH PF01488.20 EKE41533.1 - 0.0055 16.8 0.0 0.0094 16.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EKE41533.1 - 0.0068 16.6 0.4 0.21 11.9 0.1 2.2 1 1 1 2 2 2 1 TrkA-N domain NAD_binding_7 PF13241.6 EKE41533.1 - 0.011 16.1 0.0 0.024 15.1 0.0 1.6 1 1 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 EKE41533.1 - 0.04 13.3 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 EKE41533.1 - 0.067 12.4 0.2 0.097 11.9 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 EKE41533.1 - 0.069 12.4 0.0 0.37 10.0 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EKE41533.1 - 0.16 11.6 0.8 0.33 10.6 0.5 1.6 1 1 1 2 2 2 0 Ketopantoate reductase PanE/ApbA FMN_red PF03358.15 EKE41534.1 - 8.8e-19 67.8 0.0 1.3e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EKE41534.1 - 2.4e-06 27.4 0.0 3.8e-06 26.8 0.0 1.3 1 1 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 EKE41534.1 - 0.0031 17.8 0.0 0.0084 16.4 0.0 1.7 1 1 1 2 2 2 1 Flavodoxin domain GTP_EFTU PF00009.27 EKE41535.1 - 2.3e-69 232.8 0.0 3.3e-69 232.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EKE41535.1 - 5.6e-34 116.5 0.0 3.1e-33 114.1 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EKE41535.1 - 9.4e-22 76.9 0.0 2e-21 75.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EKE41535.1 - 4.6e-13 49.4 0.0 1.5e-12 47.8 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EKE41535.1 - 9e-13 48.1 0.0 2.3e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EKE41535.1 - 0.00011 22.2 0.1 0.00022 21.3 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase PRK PF00485.18 EKE41536.1 - 2e-09 37.5 0.0 2.2e-08 34.1 0.0 2.5 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 EKE41536.1 - 0.00085 19.5 0.0 0.026 14.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EKE41536.1 - 0.0042 16.8 0.0 0.0073 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EKE41536.1 - 0.0057 17.2 0.0 0.019 15.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EKE41536.1 - 0.016 14.3 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 EKE41536.1 - 0.019 15.4 0.1 0.036 14.5 0.1 1.3 1 0 0 1 1 1 0 AAA ATPase domain KTI12 PF08433.10 EKE41536.1 - 0.063 12.7 0.0 0.2 11.1 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Rad17 PF03215.15 EKE41536.1 - 0.069 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain Aminoglyc_resit PF10706.9 EKE41536.1 - 0.081 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Aminoglycoside-2''-adenylyltransferase SRP54 PF00448.22 EKE41536.1 - 0.092 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain TsaE PF02367.17 EKE41536.1 - 0.13 12.2 0.1 1.1 9.2 0.0 2.2 1 1 1 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DENN PF02141.21 EKE41537.1 - 9.9e-10 38.7 0.3 9.9e-10 38.7 0.3 2.3 3 0 0 3 3 3 1 DENN (AEX-3) domain dDENN PF03455.19 EKE41537.1 - 6e-08 32.5 6.3 6.9e-08 32.4 4.5 2.1 2 0 0 2 2 2 1 dDENN domain uDENN PF03456.18 EKE41537.1 - 0.0033 18.1 0.0 0.013 16.2 0.0 2.1 1 0 0 1 1 1 1 uDENN domain LIM PF00412.22 EKE41537.1 - 0.075 13.3 16.1 0.17 12.1 16.1 1.7 1 0 0 1 1 1 0 LIM domain Sec66 PF09802.9 EKE41538.1 - 0.047 13.3 0.0 0.096 12.3 0.0 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 Ribonuc_L-PSP PF01042.21 EKE41539.1 - 2.6e-40 137.2 0.0 3.2e-40 136.9 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP pRN1_helical PF13010.6 EKE41539.1 - 0.066 13.2 0.5 3 7.8 0.1 2.0 1 1 1 2 2 2 0 Primase helical domain TnsE_C PF18623.1 EKE41540.1 - 0.019 14.9 0.6 0.049 13.6 0.6 1.8 1 0 0 1 1 1 0 TnsE C-terminal domain MutS_V PF00488.21 EKE41541.1 - 1.2e-59 201.5 0.0 2.3e-59 200.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EKE41541.1 - 7.7e-25 88.2 2.2 7.7e-25 88.2 2.2 1.9 2 1 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EKE41541.1 - 7e-06 26.4 1.5 2.2e-05 24.7 0.1 2.3 2 0 0 2 2 2 1 MutS domain II Serinc PF03348.15 EKE41543.1 - 4.8e-48 164.2 31.6 3.1e-47 161.5 31.6 1.8 1 1 0 1 1 1 1 Serine incorporator (Serinc) Pkinase PF00069.25 EKE41544.1 - 6.7e-74 248.6 0.0 3e-73 246.4 0.0 2.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41544.1 - 8e-57 192.5 0.2 2.6e-56 190.8 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE41544.1 - 0.00049 19.5 0.0 0.0023 17.3 0.0 2.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKE41544.1 - 0.0012 18.2 1.1 0.0022 17.4 0.3 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EKE41544.1 - 0.0045 16.6 2.2 0.0057 16.3 0.2 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EKE41544.1 - 0.0068 16.4 0.0 2.9 7.7 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family DUF1107 PF06526.12 EKE41544.1 - 0.0096 15.8 0.4 8.3 6.4 0.0 3.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1107) Keratin_assoc PF09775.9 EKE41544.1 - 0.22 11.2 4.7 0.2 11.3 2.6 2.0 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 LRR_5 PF13306.6 EKE41545.1 - 2.2e-39 134.3 8.4 1.7e-21 76.5 0.7 2.3 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE41545.1 - 7.9e-05 22.3 0.2 4 7.3 0.0 3.6 1 1 2 3 3 3 2 Leucine rich repeat zf-Tim10_DDP PF02953.15 EKE41545.1 - 0.61 9.8 9.9 32 4.3 1.6 4.0 3 1 1 4 4 3 0 Tim10/DDP family zinc finger Furin-like PF00757.20 EKE41545.1 - 2.4 8.0 8.1 4.8 7.0 2.4 2.2 1 1 1 2 2 2 0 Furin-like cysteine rich region RasGAP PF00616.19 EKE41546.1 - 3.5e-12 46.5 3.3 6.6e-06 26.0 0.7 2.7 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase T4-Gluco-transf PF09198.10 EKE41546.1 - 0.34 10.5 1.3 6.5 6.5 0.1 3.4 4 0 0 4 4 4 0 Bacteriophage T4 beta-glucosyltransferase CTP_transf_like PF01467.26 EKE41549.1 - 2.7e-38 131.4 0.2 2.6e-21 76.3 0.0 2.5 2 1 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EKE41549.1 - 9.1e-07 28.9 0.3 0.039 13.8 0.1 2.8 2 1 0 2 2 2 2 FAD synthetase Pantoate_ligase PF02569.15 EKE41549.1 - 0.031 13.5 0.0 0.27 10.4 0.0 2.1 2 0 0 2 2 2 0 Pantoate-beta-alanine ligase Sigma70_ner PF04546.13 EKE41550.1 - 0.35 10.7 55.4 0.036 14.0 31.6 2.5 2 0 0 2 2 2 0 Sigma-70, non-essential region SAP30_Sin3_bdg PF13867.6 EKE41551.1 - 0.083 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 TFIIA PF03153.13 EKE41552.1 - 0.66 9.9 47.3 0.8 9.6 47.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit EF-hand_7 PF13499.6 EKE41553.1 - 0.0053 17.2 8.8 0.024 15.1 0.3 3.7 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 EKE41553.1 - 0.0059 16.4 2.2 0.018 14.9 0.4 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EKE41553.1 - 0.0078 16.1 2.5 0.0078 16.1 2.5 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 EKE41553.1 - 0.018 14.6 4.5 0.033 13.7 1.3 2.8 2 0 0 2 2 2 0 EF hand EF-hand_5 PF13202.6 EKE41553.1 - 0.31 10.6 5.3 0.11 12.0 1.1 2.5 2 0 0 2 2 2 0 EF hand DUF5381 PF17353.2 EKE41554.1 - 0.025 14.3 0.2 0.053 13.3 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5381) TMF_TATA_bd PF12325.8 EKE41555.1 - 0.096 12.9 0.7 0.096 12.9 0.7 2.5 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Sugarporin_N PF11471.8 EKE41555.1 - 0.23 11.5 0.2 0.23 11.5 0.2 1.7 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension Noelin-1 PF12308.8 EKE41555.1 - 0.62 10.1 5.8 0.19 11.7 1.3 2.2 1 1 1 2 2 2 0 Neurogenesis glycoprotein CLZ PF16526.5 EKE41555.1 - 1 9.8 4.7 0.95 9.9 1.0 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels bZIP_1 PF00170.21 EKE41555.1 - 1.2 9.3 6.1 11 6.2 1.3 2.5 2 0 0 2 2 2 0 bZIP transcription factor bZIP_2 PF07716.15 EKE41555.1 - 6.3 7.0 10.1 6.5 6.9 1.9 2.5 2 0 0 2 2 2 0 Basic region leucine zipper Malic_M PF03949.15 EKE41556.1 - 3.3e-25 88.8 0.0 4.5e-24 85.1 0.0 2.2 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EKE41556.1 - 1.5e-17 64.0 1.1 4.1e-16 59.3 1.1 2.6 1 1 0 1 1 1 1 Malic enzyme, N-terminal domain DEAD PF00270.29 EKE41557.1 - 2.4e-42 144.7 0.0 5.6e-42 143.5 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE41557.1 - 4.4e-28 97.8 0.3 5.7e-27 94.3 0.1 2.7 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE41557.1 - 5e-07 29.9 0.0 1.6e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit GUCT PF08152.12 EKE41557.1 - 6.9e-06 26.3 0.0 4.2e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 GUCT (NUC152) domain ERCC3_RAD25_C PF16203.5 EKE41557.1 - 7.4e-05 22.1 0.1 0.00013 21.3 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 EKE41557.1 - 0.0015 17.9 0.0 0.0015 17.9 0.0 2.0 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit SWI2_SNF2 PF18766.1 EKE41557.1 - 0.025 14.2 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase AAA_22 PF13401.6 EKE41557.1 - 0.027 14.7 0.0 0.13 12.6 0.0 2.0 1 1 0 1 1 1 0 AAA domain FDX-ACB PF03147.14 EKE41557.1 - 0.037 14.5 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 Ferredoxin-fold anticodon binding domain CxC1 PF18802.1 EKE41557.1 - 2.6 8.3 4.0 2.1 8.5 0.3 2.4 3 0 0 3 3 3 0 CxC1 like cysteine cluster associated with KDZ transposases CppA_C PF14507.6 EKE41558.1 - 0.47 11.2 6.0 6.8 7.5 0.2 3.8 3 1 0 3 3 3 0 CppA C-terminal zf-UBR PF02207.20 EKE41559.1 - 1.8e-15 56.9 14.2 1.8e-15 56.9 14.2 3.9 3 1 1 4 4 4 1 Putative zinc finger in N-recognin (UBR box) LRR_8 PF13855.6 EKE41560.1 - 2.8e-16 59.0 22.5 1.7e-06 27.7 1.3 3.4 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EKE41560.1 - 1.7e-14 53.6 28.3 4.7e-06 26.8 1.7 4.9 3 2 2 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EKE41560.1 - 0.01 16.3 21.9 1.4 9.7 0.2 6.6 4 2 1 5 5 5 0 Leucine Rich Repeat Pox_L5 PF04872.13 EKE41560.1 - 0.055 13.4 0.1 0.23 11.4 0.1 2.1 1 0 0 1 1 1 0 Poxvirus L5 protein family UPF0061 PF02696.14 EKE41560.1 - 0.07 11.9 1.2 0.093 11.5 1.2 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family LRR_6 PF13516.6 EKE41560.1 - 0.27 11.4 15.2 7.5 6.9 0.4 5.3 5 0 0 5 5 5 0 Leucine Rich repeat LRR_5 PF13306.6 EKE41560.1 - 0.36 10.8 8.8 0.053 13.5 3.4 2.3 2 1 1 3 3 3 0 BspA type Leucine rich repeat region (6 copies) NT-C2 PF10358.9 EKE41562.1 - 8.7e-22 77.4 1.9 1.1e-21 77.1 0.8 1.7 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins HalX PF08663.10 EKE41562.1 - 2.1e-06 27.9 0.0 4.5e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 HalX domain Cortex-I_coil PF09304.10 EKE41562.1 - 0.016 15.4 0.1 0.041 14.1 0.1 1.7 1 0 0 1 1 1 0 Cortexillin I, coiled coil Flagellin_N PF00669.20 EKE41562.1 - 0.024 14.8 0.1 0.054 13.6 0.1 1.6 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region 5TM-5TMR_LYT PF07694.12 EKE41562.1 - 0.036 13.6 0.0 0.058 12.9 0.0 1.3 1 0 0 1 1 1 0 5TMR of 5TMR-LYT Filamin PF00630.19 EKE41563.1 - 6.6e-33 113.6 6.0 2e-22 80.0 0.5 3.2 3 0 0 3 3 3 3 Filamin/ABP280 repeat Invasin_D3 PF09134.10 EKE41563.1 - 2.8e-06 27.5 0.0 0.0086 16.4 0.0 2.6 3 0 0 3 3 3 2 Invasin, domain 3 YtkA PF13115.6 EKE41563.1 - 3.5e-06 27.5 0.8 0.075 13.7 0.0 3.3 3 0 0 3 3 3 2 YtkA-like Y_Y_Y PF07495.13 EKE41563.1 - 9e-05 22.3 0.7 0.0088 16.0 0.1 3.5 4 1 0 4 4 4 1 Y_Y_Y domain PapC_N PF13954.6 EKE41563.1 - 0.017 15.1 0.0 7.6 6.5 0.0 2.6 2 0 0 2 2 2 0 PapC N-terminal domain BsuPI PF12690.7 EKE41563.1 - 0.059 13.4 1.0 14 5.8 0.0 3.0 3 0 0 3 3 3 0 Intracellular proteinase inhibitor Cadherin_5 PF17892.1 EKE41563.1 - 0.088 12.8 0.1 21 5.2 0.0 2.6 2 0 0 2 2 2 0 Cadherin-like domain MBOAT PF03062.19 EKE41564.1 - 2.9e-26 92.6 25.4 2.9e-26 92.6 25.4 1.6 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family DUF3346 PF11826.8 EKE41564.1 - 0.11 12.2 0.8 0.21 11.3 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3346) PEX11 PF05648.14 EKE41565.1 - 4.2e-15 55.8 0.2 7.2e-10 38.7 0.1 2.0 1 1 1 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) TLD PF07534.16 EKE41566.1 - 0.00012 22.3 1.0 0.00065 19.9 1.1 2.1 1 1 1 2 2 2 1 TLD PI-PLC-X PF00388.19 EKE41567.1 - 0.0013 18.4 0.2 0.0022 17.6 0.2 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain FERM_f0 PF16511.5 EKE41568.1 - 0.00035 20.8 0.0 0.00047 20.4 0.0 1.2 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM START PF01852.19 EKE41569.1 - 2.1e-06 27.3 0.0 3.2e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 START domain DUF3581 PF12119.8 EKE41569.1 - 0.035 13.5 0.6 0.4 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3581) MmcB-like PF06319.12 EKE41570.1 - 0.14 11.8 0.1 0.51 10.0 0.0 1.9 2 1 0 2 2 2 0 DNA repair protein MmcB-like NOA36 PF06524.12 EKE41570.1 - 0.41 9.9 13.0 0.59 9.4 13.0 1.2 1 0 0 1 1 1 0 NOA36 protein TINF2_N PF14973.6 EKE41570.1 - 2.1 8.7 5.9 0.94 9.8 1.8 2.5 1 1 1 3 3 3 0 TERF1-interacting nuclear factor 2 N-terminus PBP1_TM PF14812.6 EKE41570.1 - 3.7 8.0 9.2 9.8 6.6 9.2 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.12 EKE41570.1 - 5.2 6.7 15.4 9.4 5.9 15.4 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pmp3 PF01679.17 EKE41571.1 - 2.7e-18 65.9 15.9 3.1e-18 65.7 15.9 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF872 PF05915.12 EKE41571.1 - 0.023 14.9 3.3 0.025 14.8 3.3 1.0 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) NapE PF06796.11 EKE41571.1 - 0.71 9.4 3.4 0.95 9.0 3.4 1.4 1 1 0 1 1 1 0 Periplasmic nitrate reductase protein NapE Ribosomal_L44 PF00935.19 EKE41572.1 - 5.2e-34 116.6 17.5 6.9e-34 116.2 17.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 NOB1_Zn_bind PF08772.11 EKE41572.1 - 0.00077 19.6 0.8 0.00077 19.6 0.8 2.2 1 1 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like PAC3 PF10178.9 EKE41573.1 - 0.00095 19.3 0.0 0.0018 18.4 0.0 1.6 1 1 0 1 1 1 1 Proteasome assembly chaperone 3 PFEMP PF03011.15 EKE41573.1 - 0.13 12.9 0.1 0.18 12.5 0.1 1.2 1 0 0 1 1 1 0 PFEMP DBL domain BRCT PF00533.26 EKE41574.1 - 0.078 13.4 1.7 0.13 12.7 0.1 2.2 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain Myb_DNA-binding PF00249.31 EKE41575.1 - 2e-11 43.9 0.7 3.1e-11 43.3 0.7 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE41575.1 - 0.00026 21.2 0.3 0.00059 20.0 0.3 1.7 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EKE41575.1 - 0.0079 16.1 0.6 0.013 15.3 0.6 1.5 1 1 0 1 1 1 1 Myb DNA-binding like WWE PF02825.20 EKE41575.1 - 0.016 15.8 0.8 0.034 14.7 0.2 1.8 2 0 0 2 2 2 0 WWE domain Phage_C PF12025.8 EKE41575.1 - 0.11 12.4 0.3 0.18 11.7 0.3 1.4 1 0 0 1 1 1 0 Phage protein C MscS_TM PF12794.7 EKE41576.1 - 0.058 12.3 1.2 0.072 11.9 1.2 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 bZIP_C PF12498.8 EKE41576.1 - 2.1 9.3 7.6 0.89 10.5 4.2 1.9 1 1 1 2 2 2 0 Basic leucine-zipper C terminal CLAMP PF14769.6 EKE41577.1 - 0.03 14.7 2.4 8.4 6.9 2.8 2.2 1 1 1 2 2 2 0 Flagellar C1a complex subunit C1a-32 Sec7_N PF12783.7 EKE41577.1 - 0.077 12.9 2.4 0.24 11.3 0.1 2.2 1 1 1 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal FAE1_CUT1_RppA PF08392.12 EKE41578.1 - 1.1e-105 353.1 0.0 1.4e-105 352.7 0.0 1.1 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.10 EKE41578.1 - 2e-10 40.7 0.0 4.8e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Chal_sti_synt_C PF02797.15 EKE41578.1 - 3.5e-10 40.1 0.0 6.8e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EKE41578.1 - 0.00043 19.8 0.0 0.00066 19.2 0.0 1.2 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ACP_syn_III PF08545.10 EKE41578.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MSC PF09402.10 EKE41579.1 - 0.15 11.5 0.1 0.23 10.9 0.1 1.2 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain FYVE PF01363.21 EKE41581.1 - 0.00032 20.8 11.5 0.0008 19.5 11.5 1.6 1 0 0 1 1 1 1 FYVE zinc finger UNC45-central PF11701.8 EKE41581.1 - 0.017 15.1 3.4 0.8 9.7 0.1 3.3 2 1 1 3 3 3 0 Myosin-binding striated muscle assembly central Sec20 PF03908.13 EKE41582.1 - 6.4 6.8 13.9 0.7 9.9 7.3 2.5 1 1 0 2 2 2 0 Sec20 NYD-SP28_assoc PF14775.6 EKE41583.1 - 0.028 14.5 10.2 0.028 14.5 10.2 2.9 2 1 1 3 3 3 0 Sperm tail C-terminal domain DUF3375 PF11855.8 EKE41583.1 - 0.042 12.8 6.7 0.12 11.2 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3375) Herpes_BLRF2 PF05812.12 EKE41583.1 - 0.059 13.5 16.4 0.16 12.1 5.0 3.2 3 1 0 3 3 3 0 Herpesvirus BLRF2 protein bZIP_2 PF07716.15 EKE41583.1 - 0.061 13.4 0.9 0.061 13.4 0.9 4.5 4 2 1 5 5 5 0 Basic region leucine zipper Mto2_bdg PF12808.7 EKE41583.1 - 0.079 13.3 9.5 0.87 9.9 0.4 3.0 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF1845 PF08900.11 EKE41583.1 - 0.1 12.3 2.9 0.21 11.3 2.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1845) SpecificRecomb PF10136.9 EKE41583.1 - 0.11 10.8 5.9 0.14 10.5 5.9 1.1 1 0 0 1 1 1 0 Site-specific recombinase DOG1 PF14144.6 EKE41583.1 - 0.52 10.6 4.6 7.7 6.8 0.3 2.7 3 0 0 3 3 3 0 Seed dormancy control TMPIT PF07851.13 EKE41583.1 - 1.7 7.8 26.3 2.5 7.3 10.6 2.2 1 1 1 2 2 2 0 TMPIT-like protein Phage_GP20 PF06810.11 EKE41583.1 - 2.7 7.8 32.0 0.14 12.0 8.3 3.1 1 1 2 3 3 3 0 Phage minor structural protein GP20 BLOC1_2 PF10046.9 EKE41583.1 - 3.7 7.9 31.5 0.57 10.5 11.4 3.8 1 1 4 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mt_ATP-synt_D PF05873.12 EKE41583.1 - 4 7.3 20.7 1.8 8.4 6.1 2.4 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Syntaxin-6_N PF09177.11 EKE41583.1 - 5.2 7.7 22.2 0.83 10.2 9.7 2.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal CENP-O PF09496.10 EKE41583.1 - 6 6.8 11.5 1 9.3 7.4 1.7 1 1 1 2 2 2 0 Cenp-O kinetochore centromere component ZapB PF06005.12 EKE41583.1 - 7.1 7.2 45.4 0.56 10.7 23.4 3.8 2 2 1 3 3 3 0 Cell division protein ZapB CAF1 PF04857.20 EKE41583.1 - 7.5 5.6 10.4 12 5.0 10.4 1.3 1 0 0 1 1 1 0 CAF1 family ribonuclease Spc7 PF08317.11 EKE41583.1 - 7.7 5.3 37.6 4.6 6.0 20.3 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4775 PF16001.5 EKE41583.1 - 9.2 5.6 10.7 13 5.0 10.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Pkinase PF00069.25 EKE41584.1 - 1.8e-54 184.9 0.2 3.2e-54 184.1 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41584.1 - 2.6e-50 171.1 0.1 7e-50 169.7 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE41584.1 - 6.2e-09 35.1 0.0 1e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase ASH PF15780.5 EKE41584.1 - 0.0015 18.7 0.1 0.0055 16.9 0.1 1.9 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Kdo PF06293.14 EKE41584.1 - 0.05 12.9 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VSP PF03302.13 EKE41584.1 - 0.057 12.3 147.3 0.088 11.7 13.6 6.4 2 1 3 6 6 6 0 Giardia variant-specific surface protein ABC1 PF03109.16 EKE41584.1 - 0.16 12.2 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 ABC1 family GramPos_pilinBB PF16569.5 EKE41584.1 - 0.49 11.2 0.0 0.49 11.2 0.0 3.9 3 0 0 3 3 3 0 Gram-positive pilin backbone subunit 2, Cna-B-like domain SUR7 PF06687.12 EKE41585.1 - 3.1 7.4 19.3 2.9 7.5 17.8 1.6 1 1 1 2 2 2 0 SUR7/PalI family ABM PF03992.16 EKE41586.1 - 2.9e-12 46.5 0.1 3.5e-12 46.3 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Host_attach PF10116.9 EKE41587.1 - 0.018 15.6 3.0 0.023 15.3 3.0 1.1 1 0 0 1 1 1 0 Protein required for attachment to host cells RRP7 PF12923.7 EKE41588.1 - 0.0084 16.2 0.9 0.0084 16.2 0.9 3.1 2 2 1 3 3 3 2 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF5093 PF17011.5 EKE41588.1 - 0.14 12.5 0.4 0.35 11.1 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5093) Ribosomal_L21e PF01157.18 EKE41589.1 - 0.16 11.8 4.7 0.45 10.4 1.2 3.1 2 1 0 2 2 2 0 Ribosomal protein L21e PI3_PI4_kinase PF00454.27 EKE41590.1 - 2.9e-46 158.3 1.0 1.8e-45 155.8 1.0 2.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EKE41590.1 - 1.1e-10 41.2 0.2 2.7e-10 39.9 0.2 1.7 1 0 0 1 1 1 1 FATC domain RhoGAP PF00620.27 EKE41592.1 - 1.8e-28 99.3 2.2 2e-27 95.9 0.2 2.9 3 0 0 3 3 3 1 RhoGAP domain Phos_pyr_kin PF08543.12 EKE41592.1 - 0.21 11.0 1.2 12 5.2 0.0 2.8 3 0 0 3 3 3 0 Phosphomethylpyrimidine kinase Cob_adeno_trans PF01923.18 EKE41593.1 - 0.03 14.5 0.2 0.036 14.2 0.2 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Anillin_N PF16018.5 EKE41593.1 - 0.043 14.4 0.0 0.075 13.6 0.0 1.5 1 1 0 1 1 1 0 Anillin N-terminus FAM76 PF16046.5 EKE41594.1 - 0.023 14.1 1.6 0.027 13.8 1.6 1.2 1 0 0 1 1 1 0 FAM76 protein Fib_alpha PF08702.10 EKE41594.1 - 6.5 6.9 6.9 1 9.6 2.0 2.3 4 0 0 4 4 4 0 Fibrinogen alpha/beta chain family Nitroreductase PF00881.24 EKE41595.1 - 1.7e-29 103.0 0.0 2.1e-29 102.7 0.0 1.0 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 EKE41595.1 - 1.7e-11 44.1 0.2 0.00013 21.6 0.0 2.6 1 1 1 2 2 2 2 Putative TM nitroreductase Peptidase_S74 PF13884.6 EKE41595.1 - 0.012 15.9 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 Chaperone of endosialidase CSG2 PF16965.5 EKE41595.1 - 0.11 11.4 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator DHR-2 PF06920.13 EKE41596.1 - 5.1e-51 173.9 14.4 5.1e-51 173.9 14.4 4.1 5 1 0 5 5 5 1 Dock homology region 2 DOCK-C2 PF14429.6 EKE41596.1 - 1.4e-24 87.0 1.3 4.4e-24 85.4 1.3 2.0 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins EF-hand_6 PF13405.6 EKE41596.1 - 0.017 15.0 0.7 4.6 7.4 0.0 3.9 3 0 0 3 3 3 0 EF-hand domain OGG_N PF07934.12 EKE41596.1 - 0.047 13.8 2.2 8.9 6.4 0.1 4.1 2 0 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain DCB PF16213.5 EKE41596.1 - 1.4 8.6 8.1 0.17 11.5 0.9 3.1 3 0 0 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 PIN_6 PF17146.4 EKE41599.1 - 9e-26 90.2 0.1 3.8e-25 88.2 0.1 2.2 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 EKE41599.1 - 1e-20 73.6 0.5 3e-20 72.1 0.5 1.9 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Ribosomal_L37e PF01907.19 EKE41599.1 - 0.0077 16.4 0.2 0.018 15.2 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L37e RRP7 PF12923.7 EKE41599.1 - 0.016 15.3 3.3 0.016 15.3 3.3 4.2 3 1 1 4 4 4 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DZR PF12773.7 EKE41599.1 - 0.028 14.5 0.3 0.047 13.7 0.3 1.4 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 EKE41599.1 - 0.044 13.5 1.2 0.14 12.0 1.2 1.9 1 0 0 1 1 1 0 zinc-ribbon domain Oxysterol_BP PF01237.18 EKE41600.1 - 1.7e-73 247.6 10.3 1.7e-73 247.6 10.3 2.8 2 1 0 2 2 2 1 Oxysterol-binding protein Actin PF00022.19 EKE41601.1 - 1.2e-42 146.0 0.1 3.5e-41 141.1 0.1 2.2 1 1 0 1 1 1 1 Actin Ist1 PF03398.14 EKE41601.1 - 9.1e-29 100.5 0.6 1.5e-28 99.7 0.6 1.3 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Filamin PF00630.19 EKE41601.1 - 1.8e-24 86.5 4.4 7.8e-14 52.3 0.3 3.0 2 1 1 3 3 3 2 Filamin/ABP280 repeat MreB_Mbl PF06723.13 EKE41601.1 - 0.018 13.9 3.3 0.051 12.4 3.3 1.7 1 1 0 1 1 1 0 MreB/Mbl protein Invasin_D3 PF09134.10 EKE41601.1 - 0.072 13.4 0.1 2.9 8.3 0.0 2.5 2 0 0 2 2 2 0 Invasin, domain 3 Mog1 PF04603.12 EKE41601.1 - 0.086 13.2 0.0 6.6 7.1 0.0 2.7 2 0 0 2 2 2 0 Ran-interacting Mog1 protein DUF325 PF03804.13 EKE41601.1 - 0.087 12.9 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 Viral proteins of unknown function zf-CCCH PF00642.24 EKE41602.1 - 3.6e-25 87.3 14.2 8e-13 48.0 2.2 2.6 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EKE41602.1 - 3.5e-14 52.3 16.6 1.6e-07 31.2 3.3 2.3 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EKE41602.1 - 9e-13 47.7 10.6 2e-07 30.6 1.5 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 EKE41602.1 - 3.4e-05 24.5 9.4 0.0022 18.7 1.1 2.3 1 1 1 2 2 2 2 Torus domain zf-CCCH_2 PF14608.6 EKE41602.1 - 0.00017 22.0 8.7 0.03 14.8 0.6 2.6 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCHH PF10283.9 EKE41602.1 - 3.4 7.7 10.0 5 7.2 1.5 2.8 2 0 0 2 2 2 0 PBZ domain MIF4G PF02854.19 EKE41603.1 - 8.7e-19 68.0 5.8 2.8e-18 66.3 5.8 1.9 1 0 0 1 1 1 1 MIF4G domain Bravo_FIGEY PF13882.6 EKE41603.1 - 0.25 12.7 0.2 0.25 12.7 0.2 2.3 3 0 0 3 3 3 0 Bravo-like intracellular region Pkinase_Tyr PF07714.17 EKE41604.1 - 1.5e-13 50.6 0.0 2.5e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41604.1 - 4e-09 36.2 0.0 7.3e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Sec23_trunk PF04811.15 EKE41607.1 - 2.3e-48 164.9 0.0 3.8e-48 164.2 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EKE41607.1 - 2.8e-23 81.7 0.1 6.4e-23 80.5 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EKE41607.1 - 1.6e-18 67.2 0.4 5.2e-18 65.6 0.4 1.9 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EKE41607.1 - 8.4e-13 48.1 9.5 2.3e-12 46.7 9.5 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EKE41607.1 - 5.1e-07 29.5 0.0 9.3e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.6 EKE41607.1 - 0.0039 17.8 0.0 3 8.5 0.0 2.9 1 1 1 2 2 2 2 von Willebrand factor type A domain Nup54 PF13874.6 EKE41608.1 - 0.00054 20.1 1.7 0.0011 19.1 1.7 1.5 1 1 0 1 1 1 1 Nucleoporin complex subunit 54 Snapin_Pallidin PF14712.6 EKE41608.1 - 0.018 15.5 4.8 0.037 14.5 4.8 1.6 1 0 0 1 1 1 0 Snapin/Pallidin SAB PF04382.13 EKE41608.1 - 0.042 13.9 3.6 0.059 13.5 1.8 2.2 2 0 0 2 2 2 0 SAB domain Pik1 PF11522.8 EKE41608.1 - 0.13 12.3 1.2 0.4 10.7 1.2 1.9 1 0 0 1 1 1 0 Yeast phosphatidylinositol-4-OH kinase Pik1 DUF4477 PF14780.6 EKE41608.1 - 0.26 10.9 2.2 0.41 10.2 1.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4477) DUF3492 PF11997.8 EKE41608.1 - 1.3 8.7 4.3 0.24 11.1 1.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3492) LMBR1 PF04791.16 EKE41608.1 - 4.6 6.0 7.2 5.2 5.8 7.2 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein YabA PF06156.13 EKE41608.1 - 5.9 7.6 13.6 9.6 6.9 0.5 2.9 1 1 2 3 3 3 0 Initiation control protein YabA V_ATPase_I PF01496.19 EKE41608.1 - 7.3 4.4 14.9 0.36 8.7 9.2 1.6 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family TPR_1 PF00515.28 EKE41609.1 - 1.9e-27 93.9 7.8 7.6e-05 22.4 0.0 7.8 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 EKE41609.1 - 4.5e-26 88.8 6.7 0.012 15.6 0.0 8.7 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 EKE41609.1 - 2.9e-19 67.6 5.9 0.0021 18.1 0.0 8.8 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 EKE41609.1 - 2e-16 60.3 0.0 2.5e-05 24.8 0.8 4.8 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EKE41609.1 - 2.6e-11 43.6 5.8 0.02 15.2 0.3 6.0 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EKE41609.1 - 6.1e-11 42.3 0.0 0.2 11.8 0.0 5.6 1 1 3 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EKE41609.1 - 1.6e-10 40.5 3.7 0.067 12.9 0.7 6.1 3 1 3 6 6 6 3 TPR repeat TPR_7 PF13176.6 EKE41609.1 - 1.9e-08 33.8 0.9 1.1 9.4 0.0 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 EKE41609.1 - 2.8e-08 33.6 1.4 0.75 10.3 0.1 6.9 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EKE41609.1 - 5.1e-08 33.3 0.6 0.00047 20.6 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EKE41609.1 - 2.5e-07 30.9 6.9 0.059 14.0 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EKE41609.1 - 9.6e-07 29.1 1.9 7.8 7.6 0.6 7.0 3 2 4 7 7 7 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EKE41609.1 - 0.032 13.7 2.7 1.2 8.6 0.0 3.9 4 0 0 4 4 4 0 SHNi-TPR AF-4 PF05110.13 EKE41609.1 - 0.31 9.1 22.8 0.44 8.6 22.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TPR_10 PF13374.6 EKE41609.1 - 1.1 9.2 8.8 37 4.4 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Sec1 PF00995.23 EKE41610.1 - 2.7e-97 327.4 9.8 3.2e-97 327.1 9.8 1.0 1 0 0 1 1 1 1 Sec1 family DUF4763 PF15960.5 EKE41610.1 - 0.054 12.8 1.7 0.24 10.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Metallophos PF00149.28 EKE41611.1 - 3.7e-31 109.2 0.1 7.1e-31 108.3 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF4375 PF14300.6 EKE41611.1 - 0.0033 17.7 1.6 0.054 13.8 0.2 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4375) Ras PF00071.22 EKE41612.1 - 1.8e-16 60.2 0.0 2.3e-16 59.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41612.1 - 5.5e-12 46.0 0.0 8.8e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 EKE41612.1 - 0.15 11.2 0.0 0.31 10.2 0.0 1.4 2 0 0 2 2 2 0 NB-ARC domain RsgA_GTPase PF03193.16 EKE41612.1 - 0.21 11.5 0.0 5.1 7.0 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Myotub-related PF06602.14 EKE41613.1 - 2.7e-95 319.3 0.0 4.6e-95 318.5 0.0 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 EKE41613.1 - 0.037 13.9 0.1 0.11 12.3 0.1 1.8 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EKE41613.1 - 0.068 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Vps36_ESCRT-II PF11605.8 EKE41613.1 - 0.085 13.1 0.0 3.9 7.7 0.0 2.5 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 Ribosomal_L10 PF00466.20 EKE41613.1 - 0.1 12.8 0.0 0.27 11.4 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L10 RNase_Zc3h12a PF11977.8 EKE41614.1 - 9.2e-21 74.2 1.0 1.7e-20 73.4 1.0 1.4 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain CPSase_sm_chain PF00988.22 EKE41614.1 - 0.11 12.4 0.3 0.71 9.7 0.1 2.1 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase small chain, CPSase domain Mtp PF03821.16 EKE41615.1 - 0.14 11.8 9.6 0.093 12.3 6.2 1.9 1 1 1 2 2 2 0 Golgi 4-transmembrane spanning transporter TMEM132D_C PF15706.5 EKE41615.1 - 0.21 11.4 1.8 0.35 10.7 0.3 2.1 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term CheR PF01739.18 EKE41616.1 - 0.02 14.4 0.0 0.042 13.3 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Rap_GAP PF02145.15 EKE41617.1 - 3.7e-54 183.1 0.1 1.1e-53 181.6 0.1 1.8 2 0 0 2 2 2 1 Rap/ran-GAP C2 PF00168.30 EKE41617.1 - 5.7e-32 110.1 3.7 3.4e-18 65.8 0.1 2.6 2 0 0 2 2 2 2 C2 domain EF-hand_7 PF13499.6 EKE41618.1 - 0.0057 17.1 0.0 0.0094 16.4 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair Peptidase_C97 PF05903.14 EKE41621.1 - 3.3e-27 95.2 0.2 5.3e-27 94.5 0.1 1.4 1 1 0 1 1 1 1 PPPDE putative peptidase domain BLI1 PF17324.2 EKE41623.1 - 3.6 8.3 5.8 14 6.4 0.8 3.7 4 0 0 4 4 4 0 BLOC-1 interactor 1 LRR_4 PF12799.7 EKE41623.1 - 8.1 7.0 15.2 1.1e+02 3.4 0.0 7.0 6 2 2 8 8 8 0 Leucine Rich repeats (2 copies) RWD PF05773.22 EKE41624.1 - 0.0011 19.3 0.0 0.0011 19.2 0.0 1.2 1 0 0 1 1 1 1 RWD domain F-box_5 PF18511.1 EKE41624.1 - 0.12 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 F-box PNK3P PF08645.11 EKE41625.1 - 0.16 11.7 5.9 0.28 10.9 1.4 3.0 2 2 0 2 2 2 0 Polynucleotide kinase 3 phosphatase PHD_2 PF13831.6 EKE41625.1 - 1.1 8.8 9.5 5 6.8 9.5 2.2 1 0 0 1 1 1 0 PHD-finger Bromodomain PF00439.25 EKE41627.1 - 4.7e-21 74.6 2.9 1.1e-20 73.5 0.1 2.7 2 1 1 3 3 3 1 Bromodomain BET PF17035.5 EKE41627.1 - 0.48 10.6 6.4 0.077 13.2 2.2 2.0 2 0 0 2 2 2 0 Bromodomain extra-terminal - transcription regulation WD40 PF00400.32 EKE41629.1 - 0.00079 20.2 0.2 1.1 10.2 0.0 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 EKE41629.1 - 0.14 12.2 0.0 5.1 7.2 0.0 2.6 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DUF4046 PF13255.6 EKE41630.1 - 0.077 13.6 2.7 0.26 11.9 1.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4046) AbLIM_anchor PF16182.5 EKE41631.1 - 1.6 8.5 8.6 1.8 8.3 7.1 1.6 1 1 1 2 2 2 0 Putative adherens-junction anchoring region of AbLIM DUF5439 PF17507.2 EKE41631.1 - 2.5 8.4 7.6 0.46 10.7 2.2 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5439) Exo_endo_phos PF03372.23 EKE41635.1 - 4.3e-08 32.9 0.0 7e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RGS PF00615.19 EKE41636.1 - 5.1e-15 55.8 1.7 5.1e-15 55.8 1.7 3.4 3 1 0 3 3 3 1 Regulator of G protein signaling domain SAM_2 PF07647.17 EKE41636.1 - 0.12 12.6 0.0 0.45 10.7 0.0 2.0 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) YicC_N PF03755.13 EKE41636.1 - 0.16 12.5 0.8 0.46 10.9 0.2 2.1 2 0 0 2 2 2 0 YicC-like family, N-terminal region DUF948 PF06103.11 EKE41636.1 - 1.3 9.4 5.0 6.2 7.2 0.1 3.3 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) FIVAR PF07554.13 EKE41636.1 - 6.5 7.6 9.8 0.47 11.3 1.1 3.3 3 0 0 3 3 3 0 FIVAR domain Arm PF00514.23 EKE41638.1 - 0.00027 20.9 1.1 0.77 9.9 0.2 4.2 3 1 0 3 3 3 2 Armadillo/beta-catenin-like repeat IBB PF01749.20 EKE41638.1 - 0.47 10.9 12.9 0.91 10.0 12.9 1.5 1 0 0 1 1 1 0 Importin beta binding domain Pkinase_Tyr PF07714.17 EKE41639.1 - 5.9e-57 192.9 0.0 9.3e-57 192.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41639.1 - 1.1e-45 156.1 0.0 2.1e-45 155.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE41639.1 - 0.00035 19.5 0.2 0.0009 18.1 0.2 1.6 1 1 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE41639.1 - 0.0025 17.2 0.0 0.0047 16.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Diphtheria_C PF02763.14 EKE41639.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Diphtheria toxin, C domain APH PF01636.23 EKE41639.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family NGP1NT PF08153.12 EKE41640.1 - 3.7e-39 133.8 3.1 3.7e-39 133.8 3.1 2.0 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EKE41640.1 - 4.7e-16 58.9 0.1 1.2e-12 47.9 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EKE41640.1 - 1.5e-05 24.6 0.1 0.00025 20.6 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EKE41640.1 - 0.0002 21.3 0.0 0.001 19.0 0.0 2.1 1 1 0 1 1 1 1 RsgA GTPase cobW PF02492.19 EKE41640.1 - 0.0067 16.0 0.1 0.14 11.7 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.21 EKE41640.1 - 0.01 15.3 0.1 1.6 8.2 0.0 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family Roc PF08477.13 EKE41640.1 - 0.075 13.2 0.3 5.8 7.2 0.1 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EKE41640.1 - 0.079 12.5 8.0 0.087 12.3 0.0 3.9 3 2 0 4 4 4 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EKE41640.1 - 0.41 10.7 0.1 0.41 10.7 0.1 4.9 4 2 1 5 5 5 0 Dynamin family DZR PF12773.7 EKE41641.1 - 7.5e-05 22.7 2.7 0.00014 21.8 2.7 1.4 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 EKE41641.1 - 0.0022 17.6 9.3 0.0069 16.1 9.3 1.9 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 EKE41641.1 - 0.007 15.7 6.7 0.014 14.8 6.7 1.6 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 EKE41641.1 - 0.0079 16.9 4.2 0.018 15.8 4.2 1.8 1 1 0 1 1 1 1 zinc-ribbon family Cript PF10235.9 EKE41641.1 - 0.052 14.1 0.6 0.13 12.8 0.6 1.7 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT UPF0547 PF10571.9 EKE41641.1 - 0.75 9.9 6.1 1.8 8.7 6.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-NADH-PPase PF09297.11 EKE41641.1 - 6.4 6.5 8.0 1.5 8.5 2.5 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zf-CCHC_3 PF13917.6 EKE41642.1 - 2e-08 34.1 1.3 5.8e-08 32.6 1.3 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 EKE41642.1 - 0.0088 16.1 1.4 0.014 15.5 1.4 1.3 1 0 0 1 1 1 1 Zinc knuckle FtsL PF04999.13 EKE41642.1 - 0.062 13.3 1.9 0.14 12.2 1.9 1.6 1 1 0 1 1 1 0 Cell division protein FtsL Mgr1 PF08602.10 EKE41642.1 - 0.14 11.0 6.3 0.21 10.4 6.3 1.2 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Rpr2 PF04032.16 EKE41642.1 - 0.69 10.2 7.2 0.13 12.5 1.8 2.5 1 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain A_deaminase PF00962.22 EKE41644.1 - 6.2e-27 94.8 0.1 7.4e-27 94.5 0.1 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 EKE41644.1 - 0.0024 17.3 1.4 0.0085 15.4 1.4 1.9 1 1 0 1 1 1 1 Amidohydrolase family DUF2508 PF10704.9 EKE41644.1 - 0.032 14.4 0.1 3.1 8.0 0.0 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2508) DUF4318 PF14201.6 EKE41644.1 - 0.18 12.3 2.8 4.3 7.9 0.1 3.1 3 2 0 3 3 3 0 Domain of unknown function (DUF4318) Pmp3 PF01679.17 EKE41645.1 - 1.4e-13 50.8 8.2 1.5e-13 50.7 8.2 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Fe_hyd_lg_C PF02906.14 EKE41647.1 - 1.6e-48 165.5 0.1 2.3e-48 165.0 0.1 1.3 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fer4 PF00037.27 EKE41647.1 - 7.8e-14 50.8 13.9 1.1e-08 34.5 2.4 5.6 7 0 0 7 7 6 2 4Fe-4S binding domain Fer4_6 PF12837.7 EKE41647.1 - 7.2e-11 41.7 12.6 2.8e-07 30.3 2.7 6.0 7 0 0 7 7 6 2 4Fe-4S binding domain Fer4_9 PF13187.6 EKE41647.1 - 3.3e-08 33.6 34.2 0.00011 22.3 13.8 3.4 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 EKE41647.1 - 8.2e-08 32.7 37.3 0.00019 21.9 8.0 3.5 3 0 0 3 3 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EKE41647.1 - 1e-07 31.9 33.1 0.00024 21.1 2.4 5.2 3 2 3 6 6 5 3 4Fe-4S dicluster domain Fer4_11 PF13247.6 EKE41647.1 - 5.6e-06 26.4 14.6 0.0014 18.7 6.8 2.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EKE41647.1 - 6.2e-06 26.0 10.3 0.00049 20.0 1.4 5.7 6 0 0 6 6 6 3 4Fe-4S binding domain Fer4_16 PF13484.6 EKE41647.1 - 2.2e-05 25.3 33.8 0.012 16.6 1.0 5.6 5 1 1 6 6 6 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 EKE41647.1 - 4e-05 23.7 27.4 0.00018 21.6 17.7 4.8 2 2 1 3 3 3 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 EKE41647.1 - 0.00018 21.7 15.1 0.0021 18.4 4.2 6.2 6 1 0 6 6 4 2 4Fe-4S binding domain Fer4_8 PF13183.6 EKE41647.1 - 0.003 18.0 0.5 0.003 18.0 0.5 4.5 4 1 0 4 4 4 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 EKE41647.1 - 0.038 14.9 16.4 0.049 14.6 2.9 5.7 6 0 0 6 6 4 0 4Fe-4S binding domain Fer4_13 PF13370.6 EKE41647.1 - 0.055 14.0 0.8 0.055 14.0 0.8 3.9 5 1 0 5 5 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EKE41647.1 - 0.082 13.1 14.3 0.65 10.2 1.5 2.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain Acetyltransf_1 PF00583.25 EKE41648.1 - 3.7e-16 59.4 0.0 4.6e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EKE41648.1 - 7.3e-11 42.1 0.0 8.6e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EKE41648.1 - 7.1e-08 32.8 0.0 9.9e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EKE41648.1 - 1.5e-07 31.2 0.0 2.2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EKE41648.1 - 0.00011 22.2 0.0 0.00019 21.5 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EKE41648.1 - 0.0013 19.4 0.0 0.005 17.5 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EKE41648.1 - 0.0015 18.5 0.0 0.0039 17.1 0.0 1.7 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 EKE41648.1 - 0.064 12.7 0.5 0.07 12.6 0.5 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase FAD_binding_3 PF01494.19 EKE41648.1 - 0.13 11.5 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain TLD PF07534.16 EKE41651.1 - 0.0096 16.1 0.3 0.022 15.0 0.3 1.6 1 0 0 1 1 1 1 TLD RhoGAP PF00620.27 EKE41652.1 - 1.3e-38 132.3 1.0 2.4e-38 131.3 1.0 1.4 1 0 0 1 1 1 1 RhoGAP domain DUF1708 PF08101.11 EKE41652.1 - 0.011 14.9 0.0 0.014 14.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) IBN_N PF03810.19 EKE41653.1 - 2.2e-07 30.7 2.7 2.5e-07 30.5 0.6 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT PF02985.22 EKE41653.1 - 0.00012 22.1 0.0 1.1 9.7 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.20 EKE41653.1 - 0.00069 18.3 2.8 0.0067 15.0 0.0 2.6 3 0 0 3 3 3 1 Adaptin N terminal region Cnd3 PF12719.7 EKE41653.1 - 0.0059 15.8 2.2 3.1 6.9 0.0 3.2 3 1 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain UPF0147 PF03685.13 EKE41653.1 - 0.063 13.3 0.1 0.26 11.4 0.1 2.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) HEAT_EZ PF13513.6 EKE41653.1 - 0.073 13.6 0.0 4 8.0 0.0 3.4 4 0 0 4 4 4 0 HEAT-like repeat V-ATPase_H_C PF11698.8 EKE41653.1 - 0.27 11.3 1.7 9.9 6.3 0.0 3.7 4 1 1 5 5 5 0 V-ATPase subunit H DUF1947 PF09183.10 EKE41655.1 - 0.0045 17.3 0.9 0.015 15.6 0.9 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1947) RhoGEF PF00621.20 EKE41656.1 - 5.3e-17 62.6 6.3 5.3e-17 62.6 6.3 4.3 4 1 0 5 5 5 1 RhoGEF domain ArfGap PF01412.18 EKE41656.1 - 1.6e-12 47.5 0.7 1.6e-12 47.5 0.7 2.4 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH_13 PF16652.5 EKE41656.1 - 6.6e-08 32.5 0.3 6.6e-08 32.5 0.3 3.3 3 0 0 3 3 3 1 Pleckstrin homology domain CH PF00307.31 EKE41656.1 - 7.5e-08 32.5 0.2 7.5e-08 32.5 0.2 4.1 6 0 0 6 6 6 1 Calponin homology (CH) domain PH PF00169.29 EKE41656.1 - 9.2e-08 32.6 10.1 6.7e-07 29.8 0.1 4.0 4 0 0 4 4 4 2 PH domain IQ PF00612.27 EKE41656.1 - 0.00056 19.5 0.0 0.048 13.5 0.0 3.0 2 0 0 2 2 2 1 IQ calmodulin-binding motif CH_2 PF06294.11 EKE41656.1 - 0.043 13.9 0.8 0.3 11.2 0.0 3.1 3 0 0 3 3 3 0 CH-like domain in sperm protein DUF4532 PF15046.6 EKE41656.1 - 0.08 12.1 0.4 0.16 11.1 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4532) DUF2341 PF10102.9 EKE41656.1 - 0.086 13.4 0.1 0.33 11.6 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2341) DUF2433 PF10360.9 EKE41656.1 - 2.8 8.1 7.1 2.9 8.0 1.4 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2433) F-box PF00646.33 EKE41657.1 - 9.2e-08 31.8 0.3 5.6e-07 29.3 0.2 2.5 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.6 EKE41657.1 - 6.9e-07 28.8 18.7 0.15 12.2 0.2 8.4 10 0 0 10 10 10 2 Leucine Rich repeat F-box-like PF12937.7 EKE41657.1 - 4.4e-06 26.5 0.1 1.6e-05 24.7 0.1 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EKE41657.1 - 0.001 19.4 43.7 0.063 13.7 1.5 8.0 3 3 5 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE41657.1 - 1.1 9.1 34.5 1.1 9.0 0.4 6.6 2 2 3 6 6 6 0 Leucine rich repeat PP2C PF00481.21 EKE41658.1 - 7.1e-32 111.0 0.0 7.1e-32 111.0 0.0 2.6 2 1 0 3 3 3 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE41658.1 - 1.1e-06 28.7 0.0 0.0021 18.0 0.0 2.8 3 0 0 3 3 3 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EKE41658.1 - 0.0044 16.7 0.0 0.016 14.8 0.0 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C RHH_5 PF07878.11 EKE41658.1 - 0.14 12.1 0.1 0.51 10.3 0.0 2.0 2 0 0 2 2 2 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 zf-SNAP50_C PF12251.8 EKE41659.1 - 2.5e-31 108.9 6.0 5.8e-31 107.7 6.0 1.5 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal C1_2 PF03107.16 EKE41659.1 - 0.13 12.6 3.1 0.61 10.4 3.1 2.2 1 1 0 1 1 1 0 C1 domain Lectin_leg-like PF03388.13 EKE41661.1 - 5e-31 107.8 0.4 7.3e-31 107.3 0.4 1.2 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EKE41661.1 - 1.1e-12 48.4 2.3 1.5e-12 47.9 2.3 1.2 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 EKE41661.1 - 6.6e-05 22.6 1.4 0.00077 19.1 0.1 2.3 1 1 0 2 2 2 1 Legume lectin domain NDK PF00334.19 EKE41662.1 - 1.6e-27 96.2 0.0 2.9e-27 95.3 0.0 1.4 1 1 0 1 1 1 1 Nucleoside diphosphate kinase ZinT PF09223.11 EKE41662.1 - 0.25 11.2 3.1 0.53 10.2 2.8 1.6 1 1 1 2 2 2 0 ZinT (YodA) periplasmic lipocalin-like zinc-recruitment ArfGap PF01412.18 EKE41664.1 - 2e-40 137.5 2.7 2e-40 137.5 2.7 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf DUF2353 PF09789.9 EKE41665.1 - 4.7e-06 26.2 10.6 4.7e-06 26.2 10.6 4.9 2 1 2 4 4 4 1 Uncharacterized coiled-coil protein (DUF2353) CENP-F_leu_zip PF10473.9 EKE41665.1 - 0.0098 15.9 26.6 0.0098 15.9 26.6 7.5 1 1 4 5 5 5 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ribosomal_S10 PF00338.22 EKE41667.1 - 3.6e-25 88.0 0.4 4.4e-25 87.8 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e NT-C2 PF10358.9 EKE41668.1 - 1.7e-22 79.7 4.7 5.1e-22 78.2 4.7 1.8 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 EKE41668.1 - 6.5e-10 39.2 0.7 1.3e-09 38.3 0.7 1.5 1 0 0 1 1 1 1 DIL domain NPF PF16601.5 EKE41668.1 - 0.0012 19.4 49.1 0.13 12.7 18.6 3.5 1 1 2 3 3 3 3 Rabosyn-5 repeating NPF sequence-motif Ras PF00071.22 EKE41669.1 - 1.9e-53 180.4 0.0 2.3e-53 180.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41669.1 - 7e-22 77.9 0.0 1.2e-21 77.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41669.1 - 2.7e-08 33.5 0.0 3.5e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF4889 PF16230.5 EKE41670.1 - 0.018 15.2 0.2 0.077 13.2 0.2 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4889) Peptidase_C1 PF00112.23 EKE41672.1 - 1e-29 104.2 2.1 1.9e-29 103.4 2.1 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE41672.1 - 2.4e-11 43.9 5.0 4.4e-11 43.0 5.0 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF1180 PF06679.12 EKE41672.1 - 0.002 18.6 0.2 0.0038 17.7 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) Kinesin PF00225.23 EKE41673.1 - 2.8e-91 305.9 3.0 2.8e-91 305.9 3.0 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EKE41673.1 - 8.8e-25 87.4 3.8 1.1e-24 87.1 0.9 2.6 2 0 0 2 2 2 1 Microtubule binding Bac_DnaA PF00308.18 EKE41673.1 - 0.0076 16.1 2.5 0.22 11.3 1.9 2.8 2 0 0 2 2 2 1 Bacterial dnaA protein GIT_CC PF16559.5 EKE41673.1 - 0.015 15.2 6.7 0.3 11.0 0.7 4.3 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor Thioredoxin_8 PF13905.6 EKE41673.1 - 0.3 11.4 4.5 1.2 9.5 0.1 3.3 3 0 0 3 3 3 0 Thioredoxin-like Fez1 PF06818.15 EKE41673.1 - 0.83 10.1 28.8 3.3 8.1 7.5 2.7 1 1 1 2 2 2 0 Fez1 DUF1572 PF07609.11 EKE41673.1 - 1 9.2 8.7 1.4 8.7 0.9 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1572) Spc7 PF08317.11 EKE41673.1 - 5.2 5.8 38.4 2.8 6.8 7.0 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein dUTPase PF00692.19 EKE41674.1 - 2e-10 40.5 0.0 5e-10 39.2 0.0 1.6 2 0 0 2 2 2 1 dUTPase DCD PF06559.11 EKE41674.1 - 0.0012 17.7 0.0 0.0017 17.2 0.0 1.2 1 0 0 1 1 1 1 2'-deoxycytidine 5'-triphosphate deaminase (DCD) Copine PF07002.16 EKE41676.1 - 1.4e-60 204.5 0.0 1.9e-60 204.0 0.0 1.2 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EKE41676.1 - 9e-11 42.3 0.0 1.6e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EKE41676.1 - 0.00018 21.8 0.0 0.00033 21.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EKE41676.1 - 0.097 13.3 0.0 0.25 12.0 0.0 1.7 2 0 0 2 2 2 0 von Willebrand factor type A domain GAD-like PF08887.11 EKE41676.1 - 0.1 12.4 0.0 1 9.2 0.0 2.2 2 0 0 2 2 2 0 GAD-like domain PARP_reg PF02877.14 EKE41677.1 - 0.027 14.6 2.6 0.047 13.8 2.6 1.5 1 1 0 1 1 1 0 Poly(ADP-ribose) polymerase, regulatory domain DnaJ PF00226.31 EKE41678.1 - 2.8e-12 46.6 0.1 8.8e-12 45.0 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain ThiD2 PF17792.1 EKE41678.1 - 0.0087 16.5 7.4 0.014 15.8 7.3 1.3 1 1 0 1 1 1 1 ThiD2 family Gin PF10764.9 EKE41678.1 - 0.044 13.8 0.5 0.13 12.3 0.5 1.9 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin APG6_N PF17675.1 EKE41678.1 - 0.14 12.6 20.4 0.21 12.1 20.4 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region E_Pc_C PF06752.12 EKE41678.1 - 1 9.4 6.2 1.6 8.8 6.2 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus zinc_ribbon_16 PF17034.5 EKE41678.1 - 3 8.1 7.0 0.59 10.3 0.3 2.5 1 1 1 2 2 2 0 Zinc-ribbon like family COX16 PF14138.6 EKE41678.1 - 4 8.0 15.5 18 5.9 15.5 2.2 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 Fumble PF03630.14 EKE41679.1 - 8.7e-101 337.4 0.0 1e-100 337.2 0.0 1.0 1 0 0 1 1 1 1 Fumble Pkinase PF00069.25 EKE41680.1 - 4.9e-64 216.2 0.0 9.7e-64 215.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41680.1 - 3.5e-36 124.8 0.0 6.4e-36 124.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Septin PF00735.18 EKE41680.1 - 2.4e-07 30.3 0.9 0.00049 19.5 0.3 2.4 1 1 1 2 2 2 2 Septin RsgA_GTPase PF03193.16 EKE41680.1 - 7.3e-07 29.2 0.2 0.009 15.9 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE41680.1 - 8.1e-07 29.1 0.0 2.9e-06 27.3 0.0 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EKE41680.1 - 0.00019 21.7 0.0 0.00089 19.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 EKE41680.1 - 0.00049 19.9 0.5 0.026 14.3 0.0 2.8 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation EF-hand_7 PF13499.6 EKE41680.1 - 0.0015 18.9 0.5 0.023 15.2 0.5 2.7 1 1 1 2 2 2 1 EF-hand domain pair Gtr1_RagA PF04670.12 EKE41680.1 - 0.0019 17.6 0.1 0.0061 15.9 0.1 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EKE41680.1 - 0.0031 17.9 0.0 0.0071 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 EKE41680.1 - 0.0062 16.7 0.1 0.024 14.9 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EKE41680.1 - 0.0063 16.0 0.0 0.015 14.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region Ras PF00071.22 EKE41680.1 - 0.0092 15.6 0.4 0.074 12.6 0.4 2.4 1 1 0 1 1 1 1 Ras family ATPase PF06745.13 EKE41680.1 - 0.013 14.8 0.5 0.11 11.9 0.0 2.5 2 0 0 2 2 2 0 KaiC Kinase-like PF14531.6 EKE41680.1 - 0.021 14.2 0.0 0.053 12.8 0.0 1.6 1 1 0 1 1 1 0 Kinase-like SRPRB PF09439.10 EKE41680.1 - 0.036 13.5 0.0 0.12 11.8 0.0 1.9 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Sigma54_activat PF00158.26 EKE41680.1 - 0.042 13.6 0.0 0.077 12.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.6 EKE41680.1 - 0.045 14.3 0.0 0.15 12.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain EF-hand_6 PF13405.6 EKE41680.1 - 0.055 13.4 1.7 0.25 11.3 0.7 2.6 2 0 0 2 2 2 0 EF-hand domain MMR_HSR1_Xtn PF16897.5 EKE41680.1 - 0.058 13.4 0.1 0.32 11.0 0.1 2.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_5 PF07728.14 EKE41680.1 - 0.066 13.2 0.0 0.26 11.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EKE41680.1 - 0.092 13.1 0.0 0.3 11.5 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA PF00004.29 EKE41680.1 - 0.095 13.1 0.0 0.33 11.4 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EKE41680.1 - 0.1 12.2 2.5 0.28 10.8 0.0 2.6 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain EF-hand_2 PF09068.11 EKE41680.1 - 0.11 12.6 0.6 1.2 9.3 0.0 2.6 2 0 0 2 2 2 0 EF hand NACHT PF05729.12 EKE41680.1 - 0.12 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 EKE41680.1 - 0.19 11.9 0.0 0.37 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EKE41680.1 - 0.21 11.1 3.2 0.15 11.6 0.1 2.3 4 0 0 4 4 2 0 Elongation factor Tu GTP binding domain A2L_zn_ribbon PF08792.10 EKE41680.1 - 5.3 6.9 12.1 3.3 7.5 8.5 2.5 2 0 0 2 2 2 0 A2L zinc ribbon domain Ras PF00071.22 EKE41681.1 - 9.9e-46 155.3 0.1 1.2e-45 155.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41681.1 - 2e-32 111.9 0.1 3.4e-32 111.2 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41681.1 - 5.8e-16 58.4 0.1 1e-15 57.6 0.1 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE41681.1 - 6.2e-07 29.0 0.1 2e-06 27.3 0.0 1.8 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE41681.1 - 1.1e-06 28.7 0.1 0.04 13.8 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE41681.1 - 1.1e-05 25.5 0.0 1.6e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EKE41681.1 - 1.3e-05 24.9 0.4 0.00011 21.9 0.4 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EKE41681.1 - 2.5e-05 23.7 0.0 3.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA PF00004.29 EKE41681.1 - 4.1e-05 24.0 0.0 5.5e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) GTP_EFTU PF00009.27 EKE41681.1 - 0.0012 18.5 0.3 0.038 13.5 0.3 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EKE41681.1 - 0.0027 18.0 0.1 0.0045 17.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EKE41681.1 - 0.0031 17.9 0.1 0.009 16.4 0.1 1.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 EKE41681.1 - 0.0051 16.3 0.2 0.016 14.7 0.1 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 EKE41681.1 - 0.0069 16.4 0.2 0.014 15.4 0.2 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) FeoB_N PF02421.18 EKE41681.1 - 0.0077 15.8 0.0 1.9 8.0 0.1 2.2 1 1 1 2 2 2 2 Ferrous iron transport protein B MCM PF00493.23 EKE41681.1 - 0.0077 15.4 0.1 0.014 14.5 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain NACHT PF05729.12 EKE41681.1 - 0.015 15.2 0.2 0.033 14.1 0.2 1.6 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EKE41681.1 - 0.016 14.9 0.5 0.028 14.2 0.2 1.7 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EKE41681.1 - 0.085 12.6 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain G-alpha PF00503.20 EKE41681.1 - 0.56 9.3 4.9 4.4 6.4 0.2 2.4 1 1 1 3 3 3 0 G-protein alpha subunit SMC_N PF02463.19 EKE41682.1 - 3.9e-51 173.6 71.7 3.2e-31 108.5 0.0 4.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EKE41682.1 - 1.5e-19 70.4 0.0 5.6e-19 68.6 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EKE41682.1 - 9.2e-13 48.6 22.4 9.2e-13 48.6 22.4 4.8 2 2 2 4 4 2 1 AAA ATPase domain AAA_21 PF13304.6 EKE41682.1 - 9.8e-11 42.0 0.5 1.5e-05 25.0 0.4 4.5 3 2 1 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKE41682.1 - 0.00082 19.1 0.0 0.0016 18.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain TPR_MLP1_2 PF07926.12 EKE41682.1 - 0.0083 16.2 15.8 0.0083 16.2 15.8 9.7 3 3 8 11 11 9 4 TPR/MLP1/MLP2-like protein Pepsin-I3 PF06394.13 EKE41682.1 - 0.046 13.9 1.9 0.6 10.3 0.3 3.4 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain ABC_tran PF00005.27 EKE41682.1 - 0.054 14.0 0.0 0.054 14.0 0.0 7.9 3 2 1 5 5 2 0 ABC transporter NIL PF09383.10 EKE41682.1 - 0.51 10.2 3.4 42 4.1 0.0 4.5 4 0 0 4 4 4 0 NIL domain Alkyl_sulf_C PF14864.6 EKE41682.1 - 0.59 10.4 4.2 20 5.5 0.1 3.9 2 1 1 3 3 3 0 Alkyl sulfatase C-terminal HATPase_c_4 PF13749.6 EKE41682.1 - 0.93 9.7 4.6 1.1 9.5 0.4 3.6 3 1 0 3 3 3 0 Putative ATP-dependent DNA helicase recG C-terminal Mic1 PF07035.12 EKE41683.1 - 9.5e-20 70.9 2.7 1.6e-19 70.1 2.7 1.4 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like TIM PF00121.18 EKE41686.1 - 1.8e-92 309.1 5.4 2.1e-92 308.9 5.4 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase DUF3212 PF11486.8 EKE41686.1 - 0.16 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3212) CNOT1_HEAT PF16418.5 EKE41687.1 - 0.0052 16.9 2.8 0.016 15.3 0.2 2.8 2 1 1 3 3 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat APC_rep PF18797.1 EKE41687.1 - 0.016 16.2 0.4 1.8 9.6 0.1 3.6 2 1 1 3 3 3 0 Adenomatous polyposis coli (APC) repeat Methyltransf_12 PF08242.12 EKE41687.1 - 0.56 11.0 2.7 5.9 7.7 0.1 3.0 2 1 0 2 2 2 0 Methyltransferase domain Glyco_transf_41 PF13844.6 EKE41687.1 - 1.3 7.4 8.4 0.11 10.9 2.3 1.9 2 0 0 2 2 2 0 Glycosyl transferase family 41 QLQ PF08880.11 EKE41688.1 - 0.17 11.6 1.5 0.46 10.3 1.5 1.7 1 0 0 1 1 1 0 QLQ DUF4349 PF14257.6 EKE41689.1 - 0.71 9.3 8.5 0.087 12.3 2.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4349) Golgin_A5 PF09787.9 EKE41689.1 - 1.8 8.0 48.4 8.3 5.8 13.0 2.6 1 1 1 2 2 2 0 Golgin subfamily A member 5 AAA_lid_3 PF17862.1 EKE41690.1 - 4.2e-15 55.3 1.1 1.4e-14 53.6 1.1 1.9 1 1 0 1 1 1 1 AAA+ lid domain AAA PF00004.29 EKE41690.1 - 1.9e-07 31.6 0.0 5.3e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EKE41690.1 - 7.2e-06 25.9 0.2 2.6e-05 24.1 0.1 1.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain zf-C2H2_4 PF13894.6 EKE41691.1 - 0.045 14.6 0.5 1.1 10.3 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zinc_ribbon_9 PF14369.6 EKE41691.1 - 0.066 13.5 0.4 0.31 11.3 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon CTD_bind PF04818.13 EKE41691.1 - 0.1 13.4 0.2 0.24 12.2 0.2 1.6 1 0 0 1 1 1 0 RNA polymerase II-binding domain. SLBP_RNA_bind PF15247.6 EKE41692.1 - 6.4e-26 90.3 4.7 6.4e-26 90.3 4.7 1.6 2 0 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain ProSAAS PF07259.12 EKE41692.1 - 0.094 12.7 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 ProSAAS precursor ICMT PF04140.14 EKE41693.1 - 1e-26 93.2 2.7 2.8e-26 91.8 2.7 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EKE41693.1 - 8.5e-09 35.8 3.5 8.5e-09 35.8 3.5 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 EKE41693.1 - 0.00031 20.3 3.1 0.00042 19.9 3.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) SHOCT PF09851.9 EKE41694.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Short C-terminal domain Sec63 PF02889.16 EKE41695.1 - 2.8e-72 243.0 0.2 2.8e-72 243.0 0.2 1.9 2 0 0 2 2 2 1 Sec63 Brl domain DEAD PF00270.29 EKE41695.1 - 1.1e-33 116.5 11.2 1.6e-24 86.6 0.2 4.1 4 0 0 4 4 3 3 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EKE41695.1 - 2.4e-16 59.9 0.7 2.4e-16 59.9 0.7 2.8 2 0 0 2 2 2 1 N-terminal helicase PWI domain ResIII PF04851.15 EKE41695.1 - 3.9e-14 53.0 6.1 8.1e-12 45.5 0.1 4.9 5 0 0 5 5 5 2 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EKE41695.1 - 1.2e-11 45.0 0.6 0.0001 22.6 0.1 3.0 2 0 0 2 2 2 2 AAA domain Helicase_C PF00271.31 EKE41695.1 - 2.8e-10 40.5 9.8 1.9e-09 37.8 0.1 5.1 4 1 0 4 4 4 1 Helicase conserved C-terminal domain PhoH PF02562.16 EKE41695.1 - 1.6e-06 27.7 3.0 0.0029 17.1 0.1 3.3 3 0 0 3 3 3 2 PhoH-like protein DUF2075 PF09848.9 EKE41695.1 - 6.5e-05 22.3 3.4 0.0042 16.4 0.1 3.0 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 EKE41695.1 - 0.001 18.8 0.0 0.036 13.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EKE41695.1 - 0.0013 19.1 0.2 2.1 8.7 0.0 3.5 2 2 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 EKE41695.1 - 0.0019 17.7 0.2 1.3 8.5 0.1 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_19 PF13245.6 EKE41695.1 - 0.002 18.5 0.9 0.26 11.6 0.3 3.3 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EKE41695.1 - 0.0046 16.1 0.0 0.17 10.9 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA PF00004.29 EKE41695.1 - 0.01 16.3 4.6 1.3 9.5 0.2 4.2 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EKE41695.1 - 0.051 13.1 0.0 1.5 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EKE41695.1 - 0.089 12.5 0.3 5.5 6.7 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF872 PF05915.12 EKE41696.1 - 0.014 15.5 0.1 0.02 15.0 0.1 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) DUF2207 PF09972.9 EKE41696.1 - 0.1 11.3 0.0 0.12 11.2 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2374 PF09574.10 EKE41696.1 - 0.16 11.8 1.3 0.26 11.1 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (Duf2374) DUF3484 PF11983.8 EKE41696.1 - 0.39 11.9 5.0 0.23 12.6 2.5 1.7 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch TM_helix PF05552.12 EKE41696.1 - 4.8 7.2 8.4 0.14 12.2 1.5 1.9 2 0 0 2 2 2 0 Conserved TM helix Clat_adaptor_s PF01217.20 EKE41697.1 - 2.4e-26 92.4 5.3 2.7e-26 92.2 5.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain ubiquitin PF00240.23 EKE41698.1 - 2.2e-06 27.3 0.2 5.4e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family TUG-UBL1 PF11470.8 EKE41698.1 - 0.00054 20.1 0.0 0.0023 18.1 0.0 2.2 2 0 0 2 2 2 1 TUG ubiquitin-like domain Cytidylate_kin PF02224.18 EKE41698.1 - 0.076 12.7 0.1 0.1 12.3 0.1 1.1 1 0 0 1 1 1 0 Cytidylate kinase RabGAP-TBC PF00566.18 EKE41699.1 - 3.9e-33 114.9 12.9 6.3e-33 114.2 7.2 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Minor_capsid_1 PF10665.9 EKE41699.1 - 0.12 12.6 1.5 0.26 11.5 0.3 2.2 2 0 0 2 2 2 0 Minor capsid protein SANT_DAMP1_like PF16282.5 EKE41700.1 - 4.1e-13 49.3 8.3 1e-12 48.0 4.2 2.4 2 0 0 2 2 2 1 SANT/Myb-like domain of DAMP1 Myb_DNA-binding PF00249.31 EKE41700.1 - 0.0044 17.2 0.2 0.02 15.1 0.1 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF1989 PF09347.10 EKE41700.1 - 0.034 13.8 0.0 0.053 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1989) MraZ PF02381.18 EKE41700.1 - 0.13 12.2 2.1 6.3 6.9 0.0 2.9 2 1 1 3 3 3 0 MraZ protein, putative antitoxin-like FF PF01846.19 EKE41701.1 - 0.08 13.1 1.0 3.6 7.8 0.1 2.5 2 0 0 2 2 2 0 FF domain DUF778 PF05608.12 EKE41702.1 - 5.3e-15 56.3 6.4 2.9e-09 37.6 1.1 2.1 1 1 0 2 2 2 2 Protein of unknown function (DUF778) Thioredoxin PF00085.20 EKE41703.1 - 7.9e-18 64.3 0.1 4.4e-11 42.7 0.1 2.7 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EKE41703.1 - 4.3e-07 30.3 0.2 0.00057 20.3 0.2 2.5 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EKE41703.1 - 0.00071 19.9 1.1 0.0046 17.3 0.4 2.6 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.6 EKE41703.1 - 0.014 15.6 0.1 0.034 14.3 0.1 1.6 1 0 0 1 1 1 0 Thioredoxin-like DIM1 PF02966.16 EKE41704.1 - 2.3e-59 198.9 0.8 2.6e-59 198.8 0.8 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EKE41704.1 - 0.00013 21.9 0.0 0.00016 21.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DUF3192 PF11399.8 EKE41704.1 - 0.0076 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3192) Thioredoxin_8 PF13905.6 EKE41704.1 - 0.018 15.3 0.1 0.03 14.6 0.1 1.4 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_7 PF13899.6 EKE41704.1 - 0.096 12.9 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like Ras PF00071.22 EKE41705.1 - 1.4e-15 57.3 0.5 2.5e-15 56.4 0.5 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EKE41705.1 - 0.00049 20.3 0.5 0.1 12.8 0.0 2.6 1 1 2 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EKE41705.1 - 0.0035 17.3 0.4 0.25 11.2 0.0 2.2 1 1 0 2 2 2 1 RsgA GTPase Ligase_CoA PF00549.19 EKE41705.1 - 0.0043 16.9 0.0 0.0063 16.3 0.0 1.2 1 0 0 1 1 1 1 CoA-ligase AAA_15 PF13175.6 EKE41705.1 - 0.01 15.6 3.4 0.56 9.9 3.4 2.1 1 1 0 1 1 1 0 AAA ATPase domain CENP-M PF11111.8 EKE41705.1 - 0.044 13.0 0.0 0.07 12.3 0.0 1.3 1 0 0 1 1 1 0 Centromere protein M (CENP-M) AAA_28 PF13521.6 EKE41705.1 - 0.078 13.2 0.0 0.16 12.2 0.0 1.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EKE41705.1 - 0.086 12.9 0.1 0.26 11.4 0.1 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase RRM_1 PF00076.22 EKE41706.1 - 6.7e-25 86.7 0.1 9.4e-13 47.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EKE41706.1 - 0.00026 21.3 0.7 0.1 12.8 0.0 3.5 3 1 1 4 4 4 2 Cytosolic domain of 10TM putative phosphate transporter RRM_5 PF13893.6 EKE41706.1 - 0.00069 19.2 0.0 0.0055 16.3 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE41706.1 - 0.0098 15.9 0.0 0.38 10.8 0.0 2.6 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Peptidase_C2 PF00648.21 EKE41707.1 - 3.6e-72 242.9 0.0 4.6e-72 242.6 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease LIM PF00412.22 EKE41707.1 - 2.7e-07 30.7 3.1 8.4e-07 29.1 3.1 1.9 1 0 0 1 1 1 1 LIM domain Rtt106_N PF18215.1 EKE41707.1 - 0.058 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain ADK_lid PF05191.14 EKE41707.1 - 0.32 11.0 2.8 8.8 6.4 0.1 2.8 2 0 0 2 2 2 0 Adenylate kinase, active site lid DZR PF12773.7 EKE41707.1 - 0.4 10.7 7.3 4.2 7.5 7.3 2.5 1 1 0 1 1 1 0 Double zinc ribbon C1_1 PF00130.22 EKE41707.1 - 0.88 9.5 8.9 0.94 9.4 2.9 3.4 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-ribbon_3 PF13248.6 EKE41707.1 - 3.4 7.2 7.7 12 5.4 0.1 3.3 4 0 0 4 4 4 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EKE41707.1 - 6.4 6.6 9.9 6.8 6.6 0.3 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Pkinase PF00069.25 EKE41708.1 - 1.1e-50 172.4 0.0 1.4e-50 172.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41708.1 - 3e-23 82.4 0.0 4.1e-23 82.0 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE41708.1 - 0.0036 16.7 0.0 0.0048 16.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EKE41708.1 - 0.0069 16.3 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family GUN4_N PF16416.5 EKE41708.1 - 0.074 13.0 0.0 1.9 8.5 0.0 2.2 2 0 0 2 2 2 0 ARM-like repeat domain, GUN4-N terminal Pkinase_fungal PF17667.1 EKE41708.1 - 0.21 10.3 0.1 0.28 9.9 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase RhoGAP PF00620.27 EKE41709.1 - 3.3e-25 88.7 0.8 3.3e-25 88.7 0.8 2.0 2 0 0 2 2 2 1 RhoGAP domain CortBP2 PF09727.9 EKE41709.1 - 0.13 12.1 1.3 17 5.2 0.1 2.6 2 0 0 2 2 2 0 Cortactin-binding protein-2 zf-C4H2 PF10146.9 EKE41709.1 - 2.5 8.4 10.6 3.2 8.0 0.1 3.3 3 0 0 3 3 3 0 Zinc finger-containing protein tRNA-synt_2c PF01411.19 EKE41710.1 - 5.4e-06 25.2 5.5 7.7e-06 24.7 5.5 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) PEN-2 PF10251.9 EKE41710.1 - 0.062 13.7 3.8 0.28 11.6 3.8 2.2 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase DUF957 PF06117.11 EKE41710.1 - 0.13 11.8 0.5 13 5.5 0.0 3.2 3 0 0 3 3 3 0 Enterobacterial protein of unknown function (DUF957) Arm PF00514.23 EKE41711.1 - 6.8e-07 29.1 5.3 0.00054 19.9 0.5 5.1 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat IBB PF01749.20 EKE41711.1 - 0.1 13.1 1.7 0.24 11.8 1.7 1.6 1 0 0 1 1 1 0 Importin beta binding domain DUF1765 PF08578.10 EKE41711.1 - 0.15 12.6 2.0 0.27 11.7 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1765) MatC_N PF07158.11 EKE41712.1 - 9.7 6.2 13.3 0.25 11.3 5.1 2.2 2 0 0 2 2 2 0 Dicarboxylate carrier protein MatC N-terminus DJ-1_PfpI PF01965.24 EKE41713.1 - 1.9e-44 151.3 0.1 2.2e-44 151.2 0.1 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 EKE41713.1 - 0.019 14.5 0.1 0.027 14.0 0.1 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain zf-ribbon_3 PF13248.6 EKE41714.1 - 0.00012 21.3 0.9 0.00012 21.3 0.9 2.3 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EKE41714.1 - 0.0002 21.0 1.9 0.0002 21.0 1.9 2.4 2 0 0 2 2 2 1 zinc-ribbon domain LIM PF00412.22 EKE41714.1 - 0.00039 20.6 1.2 0.00039 20.6 1.2 2.4 2 1 0 2 2 2 1 LIM domain DZR PF12773.7 EKE41714.1 - 0.00063 19.7 5.5 0.0016 18.4 5.5 1.7 1 1 0 1 1 1 1 Double zinc ribbon UPF0547 PF10571.9 EKE41714.1 - 0.013 15.6 12.6 0.11 12.6 1.2 3.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 zf-RING-like PF08746.11 EKE41714.1 - 0.04 14.2 1.0 0.04 14.2 1.0 2.6 3 1 0 3 3 2 0 RING-like domain GHL6 PF14871.6 EKE41714.1 - 0.063 13.4 0.1 0.079 13.1 0.1 1.3 1 1 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 Cytochrom_c3_2 PF14537.6 EKE41714.1 - 0.072 13.6 1.7 0.084 13.3 1.7 1.1 1 0 0 1 1 1 0 Cytochrome c3 NOB1_Zn_bind PF08772.11 EKE41714.1 - 0.078 13.2 0.8 0.078 13.2 0.8 2.0 2 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Cript PF10235.9 EKE41714.1 - 0.081 13.5 6.5 0.39 11.3 1.5 2.2 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT RNA_POL_M_15KD PF02150.16 EKE41714.1 - 0.083 12.8 1.1 0.083 12.8 1.1 2.2 2 1 0 2 2 2 0 RNA polymerases M/15 Kd subunit zinc_ribbon_15 PF17032.5 EKE41714.1 - 0.12 13.2 7.6 0.43 11.4 7.6 1.8 1 1 0 1 1 1 0 zinc-ribbon family DUF2175 PF09943.9 EKE41714.1 - 0.31 11.3 3.2 0.23 11.8 1.7 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) C1_1 PF00130.22 EKE41714.1 - 0.36 10.8 7.0 5.8 6.9 1.0 2.9 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-NADH-PPase PF09297.11 EKE41714.1 - 0.43 10.3 8.2 4.3 7.1 0.7 3.3 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain HypA PF01155.19 EKE41714.1 - 0.6 10.1 5.3 2.4 8.2 5.3 1.8 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ribosomal_L37e PF01907.19 EKE41714.1 - 1.7 8.8 8.1 3.1 8.0 1.0 2.6 2 1 0 2 2 2 0 Ribosomal protein L37e zf_UBZ PF18439.1 EKE41714.1 - 2.2 8.0 11.1 1.8 8.2 0.6 3.2 2 2 1 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-ACC PF17848.1 EKE41714.1 - 2.3 8.4 9.6 4.9 7.3 0.1 3.3 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain zf-Mss51 PF13824.6 EKE41714.1 - 2.6 8.2 8.5 2.8 8.1 0.5 2.7 1 1 2 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Ribosomal_L32p PF01783.23 EKE41714.1 - 3.2 8.1 7.2 3.4 8.0 2.1 2.6 1 1 1 2 2 2 0 Ribosomal L32p protein family Nudix_N_2 PF14803.6 EKE41714.1 - 5 7.1 8.5 18 5.4 0.1 3.1 3 0 0 3 3 3 0 Nudix N-terminal zf-C2H2 PF00096.26 EKE41714.1 - 6 7.5 8.3 48 4.7 0.1 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type YhfH PF14149.6 EKE41714.1 - 8.6 6.4 8.9 24 5.0 0.8 3.2 2 1 1 3 3 3 0 YhfH-like protein Zn_ribbon_recom PF13408.6 EKE41714.1 - 9.7 6.8 11.4 1.4 9.5 1.8 2.8 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Hist_deacetyl PF00850.19 EKE41715.1 - 6.1e-05 22.7 0.8 6.1e-05 22.7 0.8 2.4 2 1 0 2 2 2 1 Histone deacetylase domain Baculo_19 PF04798.12 EKE41715.1 - 0.2 11.3 2.2 0.51 10.1 2.2 1.6 1 0 0 1 1 1 0 Baculovirus 19 kDa protein conserved region SLC35F PF06027.12 EKE41716.1 - 9.2e-30 104.2 32.7 1.2e-29 103.8 32.7 1.1 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 EKE41716.1 - 1.1e-07 32.1 46.7 0.00012 22.3 22.5 2.2 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EKE41716.1 - 1.6e-06 27.3 15.3 1.6e-06 27.3 15.3 2.2 1 1 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 EKE41716.1 - 3.5e-05 23.3 26.6 4.6e-05 22.9 26.6 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family Ras PF00071.22 EKE41717.1 - 7.5e-37 126.4 0.7 9.3e-37 126.1 0.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41717.1 - 9e-29 100.1 0.1 1.3e-28 99.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41717.1 - 3.7e-11 42.8 0.2 4.3e-11 42.6 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE41717.1 - 1.8e-05 24.3 0.2 2.1e-05 24.0 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 EKE41717.1 - 0.0013 18.2 0.3 0.0043 16.6 0.1 1.9 2 1 0 2 2 2 1 P-loop containing dynein motor region G-alpha PF00503.20 EKE41717.1 - 0.0026 17.0 0.4 0.012 14.8 0.1 2.2 1 1 1 2 2 2 1 G-protein alpha subunit RsgA_GTPase PF03193.16 EKE41717.1 - 0.0074 16.2 0.2 1.2 9.0 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase NTPase_1 PF03266.15 EKE41717.1 - 0.0082 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 NTPase AAA_22 PF13401.6 EKE41717.1 - 0.022 15.1 0.0 0.13 12.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EKE41717.1 - 0.023 14.7 0.0 0.046 13.8 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase FeoB_N PF02421.18 EKE41717.1 - 0.046 13.2 0.0 0.61 9.6 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.9 EKE41717.1 - 0.052 13.3 0.3 0.13 12.0 0.3 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 EKE41717.1 - 0.1 12.4 0.7 4.9 6.9 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein zf-HC5HC2H_2 PF13832.6 EKE41717.1 - 0.11 12.7 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain NB-ARC PF00931.22 EKE41717.1 - 0.16 11.2 0.6 0.22 10.7 0.6 1.4 1 1 0 1 1 1 0 NB-ARC domain CNOT11 PF10155.9 EKE41718.1 - 9.4e-21 74.3 3.7 1.9e-20 73.3 3.7 1.5 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 Vip3A_N PF12495.8 EKE41718.1 - 4.7 7.1 8.5 4.8 7.0 0.6 2.4 2 1 0 2 2 2 0 Vegetative insecticide protein 3A N terminal SMK-1 PF04802.15 EKE41719.1 - 8.5e-15 55.1 5.9 2.1e-14 53.8 3.3 2.6 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 DUF2935 PF11155.8 EKE41719.1 - 0.048 14.0 0.9 0.76 10.1 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) RGS PF00615.19 EKE41719.1 - 0.43 10.9 8.5 0.08 13.2 0.9 3.7 3 1 0 3 3 3 0 Regulator of G protein signaling domain LRR_5 PF13306.6 EKE41721.1 - 7.9e-88 291.0 34.7 6.3e-36 123.2 10.0 3.7 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE41721.1 - 2.2e-20 72.2 0.0 0.0001 22.0 0.0 6.5 3 2 4 7 7 7 5 Leucine rich repeat DHHC PF01529.20 EKE41722.1 - 6.1e-32 110.5 8.7 6.1e-32 110.5 8.7 2.3 2 2 0 2 2 2 1 DHHC palmitoyltransferase PolC_DP2 PF03833.13 EKE41722.1 - 2.5 5.9 4.8 3.1 5.5 4.8 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Aminotran_5 PF00266.19 EKE41723.1 - 3e-34 118.6 0.0 4.4e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EKE41723.1 - 2.5e-10 40.1 0.2 8.4e-10 38.3 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class I and II E1-E2_ATPase PF00122.20 EKE41724.1 - 2e-42 144.7 5.4 2e-42 144.7 5.4 3.2 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EKE41724.1 - 1.4e-40 139.0 7.2 1.4e-40 139.0 7.2 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EKE41724.1 - 2e-24 87.0 1.0 1.9e-20 74.0 0.1 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EKE41724.1 - 7.5e-19 67.2 0.0 2e-18 65.8 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EKE41724.1 - 1.2e-18 67.0 0.1 2.5e-18 66.0 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EKE41724.1 - 3.8e-08 33.4 0.6 1.3e-05 25.1 0.3 3.0 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase COX1 PF00115.20 EKE41724.1 - 0.35 9.7 11.6 2.4 6.9 0.6 2.7 2 0 0 2 2 2 0 Cytochrome C and Quinol oxidase polypeptide I Adaptin_N PF01602.20 EKE41725.1 - 3.7e-58 197.4 34.8 5.9e-58 196.7 34.8 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EKE41725.1 - 6e-48 162.1 0.1 2.8e-47 159.9 0.1 2.3 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EKE41725.1 - 1.5e-27 96.3 0.4 4.2e-27 94.8 0.4 1.8 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 EKE41725.1 - 1.3e-06 28.6 0.1 0.095 13.1 0.1 4.6 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 EKE41725.1 - 0.00081 19.4 1.4 2.8 8.4 0.0 4.8 4 1 0 4 4 4 1 HEAT repeat Cnd1 PF12717.7 EKE41725.1 - 0.003 17.6 20.0 0.0033 17.5 2.8 3.8 1 1 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 DUF4992 PF16383.5 EKE41725.1 - 0.019 14.5 0.2 0.038 13.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function AP4E_app_platf PF14807.6 EKE41725.1 - 0.06 13.7 0.3 0.4 11.1 0.0 2.6 2 0 0 2 2 2 0 Adaptin AP4 complex epsilon appendage platform PriA_C PF18074.1 EKE41725.1 - 0.079 13.8 0.6 0.34 11.8 0.6 2.2 1 0 0 1 1 1 0 Primosomal protein N C-terminal domain DHR10 PF18595.1 EKE41725.1 - 0.079 13.0 5.4 0.19 11.8 0.1 2.7 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain GED PF02212.18 EKE41725.1 - 2.1 8.5 8.4 19 5.5 0.1 4.1 4 0 0 4 4 4 0 Dynamin GTPase effector domain BING4CT PF08149.11 EKE41726.1 - 3.1e-28 97.4 0.1 5.5e-27 93.4 0.0 2.7 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.32 EKE41726.1 - 1.7e-07 31.8 0.1 0.00087 20.1 0.0 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE41726.1 - 5.3e-05 23.4 0.0 0.21 11.9 0.0 4.0 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain CNH PF00780.22 EKE41726.1 - 0.044 13.4 0.0 0.097 12.3 0.0 1.5 1 0 0 1 1 1 0 CNH domain Syd PF07348.12 EKE41726.1 - 0.05 13.3 0.1 0.089 12.5 0.1 1.3 1 0 0 1 1 1 0 Syd protein (SUKH-2) TLD PF07534.16 EKE41728.1 - 7e-07 29.5 0.5 2.2e-06 27.9 0.3 2.0 1 1 1 2 2 2 1 TLD RRM_1 PF00076.22 EKE41728.1 - 0.024 14.4 0.1 0.063 13.1 0.1 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DEAD PF00270.29 EKE41729.1 - 3.4e-37 127.9 0.0 1.3e-36 126.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE41729.1 - 7.9e-28 97.0 1.0 1.6e-27 96.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE41729.1 - 9.4e-08 32.2 0.1 2.4e-07 30.9 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EKE41729.1 - 0.045 14.0 1.4 1.7 8.9 0.0 3.2 3 1 0 3 3 3 0 AAA domain OKR_DC_1 PF01276.20 EKE41730.1 - 1.5e-125 419.2 0.1 1.8e-80 270.7 0.3 2.4 2 0 0 2 2 2 2 Orn/Lys/Arg decarboxylase, major domain OKR_DC_1_C PF03711.15 EKE41730.1 - 1.5e-25 90.0 0.0 4.3e-25 88.5 0.0 1.8 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, C-terminal domain OKR_DC_1_N PF03709.15 EKE41730.1 - 3.7e-10 40.1 0.2 1.8e-06 28.2 0.1 3.3 3 0 0 3 3 3 2 Orn/Lys/Arg decarboxylase, N-terminal domain Beta_elim_lyase PF01212.21 EKE41730.1 - 0.092 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase NARP1 PF12569.8 EKE41731.1 - 1.1e-43 149.9 15.8 2.5e-42 145.5 14.8 2.5 2 1 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EKE41731.1 - 1.3e-14 53.0 13.4 0.00052 19.9 0.0 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 EKE41731.1 - 1.1e-09 38.8 2.1 8.2 7.2 0.0 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EKE41731.1 - 3.4e-09 36.7 4.1 0.74 10.8 0.0 6.8 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EKE41731.1 - 8.1e-09 34.9 10.6 0.038 13.8 0.5 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EKE41731.1 - 1.4e-08 35.1 10.5 0.36 11.4 0.0 6.2 6 1 0 6 6 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EKE41731.1 - 1.8e-06 27.7 12.8 0.0099 16.0 0.0 5.7 7 0 0 7 7 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE41731.1 - 1.1e-05 25.6 14.5 1.2 9.4 0.3 6.1 5 2 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EKE41731.1 - 6.7e-05 23.1 9.1 0.047 14.0 0.1 5.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKE41731.1 - 7.5e-05 22.3 11.8 0.0053 16.4 1.3 4.9 6 0 0 6 6 4 2 TPR repeat TPR_6 PF13174.6 EKE41731.1 - 8.8e-05 22.9 4.4 0.91 10.3 0.1 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EKE41731.1 - 0.00012 21.9 0.5 5.1 7.4 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EKE41731.1 - 0.008 15.4 1.4 0.22 10.7 0.1 2.9 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EKE41731.1 - 0.015 15.6 10.1 29 5.3 0.0 6.3 7 0 0 7 7 6 0 Tetratricopeptide repeat PPR PF01535.20 EKE41731.1 - 0.022 15.0 2.7 21 5.6 0.0 4.9 5 0 0 5 5 5 0 PPR repeat DUF915 PF06028.11 EKE41731.1 - 0.035 13.4 0.6 0.071 12.4 0.6 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF3922 PF13059.6 EKE41731.1 - 0.061 13.8 9.3 0.22 12.0 3.8 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3992) Fis1_TPR_C PF14853.6 EKE41731.1 - 0.2 11.7 4.2 0.42 10.7 0.0 3.5 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Vps39_1 PF10366.9 EKE41731.1 - 0.45 10.8 9.1 13 6.2 0.1 4.3 2 1 3 5 5 5 0 Vacuolar sorting protein 39 domain 1 5_3_exonuc PF01367.20 EKE41731.1 - 2.4 8.8 4.4 2.3 8.9 0.6 2.8 3 0 0 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold ParcG PF10274.9 EKE41732.1 - 0.0092 16.1 1.6 0.71 10.0 0.1 3.0 2 0 0 2 2 2 1 Parkin co-regulated protein CTK3 PF12243.8 EKE41732.1 - 0.019 14.9 5.1 0.95 9.5 0.1 4.2 3 0 0 3 3 3 0 CTD kinase subunit gamma CTK3 Trans_coact PF16805.5 EKE41732.1 - 0.028 14.5 0.1 0.13 12.4 0.1 2.2 1 0 0 1 1 1 0 Phage late-transcription coactivator Ipi1_N PF12333.8 EKE41732.1 - 0.029 15.0 0.1 22 5.7 0.0 4.1 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation UNC45-central PF11701.8 EKE41732.1 - 0.19 11.7 11.4 0.21 11.6 0.1 4.1 3 1 1 4 4 4 0 Myosin-binding striated muscle assembly central Importin_rep_4 PF18808.1 EKE41732.1 - 0.29 11.4 1.4 2.1 8.7 0.7 2.8 2 0 0 2 2 2 0 Importin repeat Arm PF00514.23 EKE41732.1 - 0.88 9.7 3.4 22 5.2 0.2 3.3 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EKE41732.1 - 1.5 8.8 14.8 0.29 11.2 0.2 4.8 4 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EKE41732.1 - 6 7.5 14.8 12 6.5 0.0 6.9 7 1 1 8 8 8 0 Vacuolar 14 Fab1-binding region Peptidase_S28 PF05577.12 EKE41733.1 - 1e-10 41.0 0.0 1.4e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase S28 PP2C_2 PF13672.6 EKE41734.1 - 3.6e-10 39.8 0.0 6.3e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE41734.1 - 0.071 13.0 0.0 0.21 11.5 0.0 1.7 1 1 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) RasGEF PF00617.19 EKE41735.1 - 1.8e-14 54.3 0.8 3.9e-14 53.3 0.8 1.6 1 0 0 1 1 1 1 RasGEF domain Ras PF00071.22 EKE41736.1 - 2.1e-52 177.0 2.1 2.5e-52 176.7 2.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41736.1 - 1.6e-19 70.2 0.1 3.1e-19 69.4 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41736.1 - 5.6e-11 42.2 1.2 7.2e-11 41.9 1.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE41736.1 - 5.6e-05 23.1 0.3 0.011 15.6 0.3 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EKE41736.1 - 0.00088 18.9 2.0 0.0017 17.9 1.1 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 EKE41736.1 - 0.019 15.0 0.2 0.042 13.9 0.2 1.7 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain NB-ARC PF00931.22 EKE41736.1 - 0.048 12.8 1.7 0.28 10.3 1.7 2.2 1 1 0 1 1 1 0 NB-ARC domain VSP PF03302.13 EKE41738.1 - 0.072 11.9 107.5 0.11 11.4 81.5 3.3 1 1 1 2 2 2 0 Giardia variant-specific surface protein BRCA-2_OB1 PF09103.10 EKE41739.1 - 1.8e-23 82.8 0.1 1.8e-23 82.8 0.1 2.5 3 0 0 3 3 3 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 DUF5617 PF18493.1 EKE41739.1 - 0.12 12.5 4.1 0.11 12.7 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5617) RabGAP-TBC PF00566.18 EKE41740.1 - 2e-42 145.3 7.1 5.3e-42 143.9 7.1 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF2461 PF09365.10 EKE41740.1 - 0.006 16.6 0.2 0.014 15.4 0.2 1.6 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) DUF3294 PF07957.11 EKE41740.1 - 0.017 14.9 2.2 0.028 14.2 1.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3294) Arf PF00025.21 EKE41741.1 - 6.2e-61 204.9 0.7 6.8e-61 204.7 0.7 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EKE41741.1 - 8.9e-16 58.0 0.5 6.1e-12 45.4 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EKE41741.1 - 5.1e-14 52.2 0.1 5.9e-14 52.0 0.1 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EKE41741.1 - 1.3e-12 47.5 0.2 1.6e-12 47.3 0.2 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EKE41741.1 - 5.8e-12 45.9 0.0 8.3e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EKE41741.1 - 2e-06 27.9 0.1 3.1e-06 27.2 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE41741.1 - 7.7e-06 25.4 0.1 9.2e-06 25.2 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EKE41741.1 - 0.0079 15.7 3.3 0.029 13.9 3.3 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF4367 PF14285.6 EKE41741.1 - 0.047 14.1 1.4 0.19 12.1 0.2 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4367) Pkinase PF00069.25 EKE41742.1 - 2e-57 194.5 0.0 2.5e-57 194.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41742.1 - 1e-27 97.1 0.0 3.4e-27 95.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE41742.1 - 0.0012 18.3 0.0 0.0025 17.2 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 EKE41742.1 - 0.0042 16.7 0.1 0.0083 15.7 0.1 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKE41742.1 - 0.014 15.4 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EKE41742.1 - 0.015 14.7 0.0 0.027 13.8 0.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1679 PF07914.11 EKE41742.1 - 0.019 13.8 0.5 0.42 9.4 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) GP44 PF17510.2 EKE41743.1 - 0.072 13.4 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Gene product 44 DUF932 PF06067.11 EKE41743.1 - 0.074 12.8 0.5 0.1 12.3 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF932) DUF3945 PF13101.6 EKE41743.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3945) Bin3 PF06859.12 EKE41743.1 - 0.29 11.8 1.8 0.5 11.0 1.8 1.4 1 0 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) DUF1659 PF07872.11 EKE41744.1 - 0.093 12.4 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1659) GFO_IDH_MocA PF01408.22 EKE41744.1 - 0.1 13.5 0.2 0.45 11.4 0.2 2.0 1 1 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Glyco_hydro_20 PF00728.22 EKE41745.1 - 2e-85 287.3 4.2 2.4e-85 287.0 4.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EKE41745.1 - 1.1e-14 55.3 0.0 2.6e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EKE41745.1 - 3e-05 24.8 0.0 6e-05 23.8 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Peptidase_M76 PF09768.9 EKE41748.1 - 0.03 14.1 0.3 0.036 13.8 0.3 1.2 1 0 0 1 1 1 0 Peptidase M76 family Baculo_ME53 PF06061.11 EKE41748.1 - 0.092 12.0 0.2 0.092 12.0 0.2 1.9 1 1 1 2 2 2 0 Baculoviridae ME53 Sec8_exocyst PF04048.14 EKE41749.1 - 0.0064 16.4 6.0 0.054 13.4 0.1 3.3 1 1 2 3 3 3 1 Sec8 exocyst complex component specific domain COX4 PF02936.14 EKE41749.1 - 0.045 13.8 1.0 0.12 12.4 0.4 2.0 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV DUF4200 PF13863.6 EKE41749.1 - 0.053 13.9 9.3 1.5 9.2 1.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) WH2 PF02205.20 EKE41749.1 - 0.11 12.4 0.1 0.11 12.4 0.1 2.8 3 0 0 3 3 3 0 WH2 motif FemAB_like PF04339.12 EKE41749.1 - 0.11 11.6 0.7 0.17 11.0 0.7 1.2 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition RIH_assoc PF08454.11 EKE41749.1 - 0.44 10.4 2.9 0.35 10.8 0.3 2.0 2 0 0 2 2 2 0 RyR and IP3R Homology associated Cgr1 PF03879.14 EKE41751.1 - 5.2e-07 30.0 19.9 5.2e-07 30.0 19.9 2.1 2 0 0 2 2 2 1 Cgr1 family DUF3619 PF12279.8 EKE41751.1 - 0.054 13.8 3.0 0.086 13.2 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) YniB PF14002.6 EKE41751.1 - 4.7 6.9 8.2 0.22 11.3 2.9 1.5 2 0 0 2 2 2 0 YniB-like protein HA2 PF04408.23 EKE41752.1 - 5e-27 94.3 0.0 5e-27 94.3 0.0 3.2 2 1 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EKE41752.1 - 1.1e-22 80.2 0.0 2.9e-22 78.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EKE41752.1 - 1e-12 48.4 0.0 5.4e-12 46.0 0.0 2.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EKE41752.1 - 2.5e-07 30.6 0.1 7.8e-07 29.0 0.1 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EKE41752.1 - 4.1e-06 27.1 0.1 1e-05 25.8 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EKE41752.1 - 0.00034 20.4 0.0 0.00065 19.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKE41752.1 - 0.0008 19.8 0.0 0.002 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EKE41752.1 - 0.0025 17.8 0.0 0.0051 16.8 0.0 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain T2SSE PF00437.20 EKE41752.1 - 0.0052 15.9 0.6 0.047 12.8 0.7 2.6 3 1 0 3 3 3 1 Type II/IV secretion system protein ABC_tran PF00005.27 EKE41752.1 - 0.0055 17.2 0.7 0.0055 17.2 0.7 3.5 1 1 1 2 2 1 1 ABC transporter AAA_14 PF13173.6 EKE41752.1 - 0.0067 16.5 4.5 0.024 14.7 0.6 3.5 3 1 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 EKE41752.1 - 0.067 13.1 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase SRP54 PF00448.22 EKE41752.1 - 0.12 12.0 0.0 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Pkinase_Tyr PF07714.17 EKE41753.1 - 1.1e-26 93.7 0.0 1.4e-26 93.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41753.1 - 1.9e-22 79.9 0.0 3.6e-22 79.0 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Tubulin PF00091.25 EKE41754.1 - 1.3e-68 231.1 0.1 1.1e-67 228.1 0.1 2.0 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EKE41754.1 - 1.6e-38 131.7 0.0 2.5e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EKE41754.1 - 2.8e-05 24.4 0.0 5.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EKE41754.1 - 0.011 15.4 0.0 0.029 14.1 0.0 1.7 2 0 0 2 2 2 0 Tubulin domain RecT PF03837.14 EKE41754.1 - 0.036 13.5 0.0 0.06 12.8 0.0 1.3 1 0 0 1 1 1 0 RecT family PALP PF00291.25 EKE41755.1 - 3.6e-69 233.4 0.5 4.3e-69 233.2 0.5 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT_4 PF13291.6 EKE41755.1 - 1.1e-06 29.1 0.8 1.3e-05 25.7 0.0 2.5 2 0 0 2 2 2 1 ACT domain Radical_SAM PF04055.21 EKE41755.1 - 0.031 14.7 0.0 1.1 9.6 0.0 2.5 2 1 1 3 3 3 0 Radical SAM superfamily CDC45 PF02724.14 EKE41756.1 - 6e-93 312.3 9.4 2.1e-69 234.5 5.6 3.0 1 1 1 2 2 2 2 CDC45-like protein DHHC PF01529.20 EKE41760.1 - 6.8e-25 87.7 13.6 6.8e-25 87.7 13.6 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase BSD PF03909.17 EKE41761.1 - 0.00012 22.0 0.9 0.00042 20.3 0.4 2.1 2 0 0 2 2 2 1 BSD domain TLD PF07534.16 EKE41762.1 - 4.2e-26 91.8 0.5 5e-26 91.6 0.5 1.1 1 0 0 1 1 1 1 TLD RabGAP-TBC PF00566.18 EKE41763.1 - 1.1e-27 97.2 6.8 1.1e-27 97.2 6.8 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Ph1570 PF09638.10 EKE41763.1 - 0.054 13.3 2.3 6.2 6.7 0.1 2.3 2 0 0 2 2 2 0 Ph1570 protein Pkinase PF00069.25 EKE41765.1 - 4.8e-73 245.8 0.0 6.6e-73 245.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41765.1 - 2.9e-35 121.8 0.0 4.2e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE41765.1 - 4.2e-15 56.1 0.5 9.5e-15 55.0 0.5 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EKE41765.1 - 5.2e-07 29.3 0.0 1.2e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like PH_3 PF14593.6 EKE41765.1 - 1e-06 28.8 0.5 2.7e-06 27.4 0.5 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EKE41765.1 - 5.4e-05 23.4 0.2 0.00014 22.1 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EKE41765.1 - 6.4e-05 23.3 1.3 0.00032 21.1 1.3 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain Pkinase_C PF00433.24 EKE41765.1 - 0.00077 20.1 2.4 0.0023 18.6 2.4 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.6 EKE41765.1 - 0.0021 17.7 0.3 1.3 8.6 0.2 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 PH_13 PF16652.5 EKE41765.1 - 0.044 13.6 0.5 0.088 12.6 0.5 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 EKE41765.1 - 0.14 12.5 0.2 1.1 9.7 0.1 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain Pet191_N PF10203.9 EKE41766.1 - 1.4 9.3 7.3 1.4 9.3 0.2 3.0 3 0 0 3 3 3 0 Cytochrome c oxidase assembly protein PET191 AAA PF00004.29 EKE41767.1 - 1.3e-42 145.4 0.0 3.2e-42 144.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EKE41767.1 - 1.8e-19 69.4 0.2 3.6e-19 68.5 0.2 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EKE41767.1 - 7.5e-12 44.9 0.2 1.6e-11 43.8 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EKE41767.1 - 3.2e-07 30.4 0.0 1.2e-06 28.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EKE41767.1 - 6.4e-06 26.6 0.5 0.00076 19.9 0.0 2.5 2 1 1 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 EKE41767.1 - 8.1e-06 26.1 0.4 2.5e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EKE41767.1 - 2.2e-05 24.2 0.0 5.5e-05 23.0 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EKE41767.1 - 3.4e-05 24.1 0.9 0.034 14.4 0.1 2.6 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.13 EKE41767.1 - 0.00091 18.5 0.0 0.013 14.7 0.0 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF815) PhoH PF02562.16 EKE41767.1 - 0.0016 17.9 0.2 0.017 14.6 0.1 2.3 2 0 0 2 2 2 1 PhoH-like protein Sigma54_activat PF00158.26 EKE41767.1 - 0.0032 17.2 0.3 0.065 12.9 0.0 2.6 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.6 EKE41767.1 - 0.0084 16.2 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EKE41767.1 - 0.012 15.4 0.2 0.029 14.1 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_11 PF13086.6 EKE41767.1 - 0.014 15.2 0.9 0.15 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EKE41767.1 - 0.015 14.8 0.1 0.03 13.9 0.1 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 EKE41767.1 - 0.017 14.8 0.0 0.047 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EKE41767.1 - 0.018 14.4 0.0 0.036 13.4 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EKE41767.1 - 0.027 13.8 4.7 0.04 13.3 0.1 2.7 2 1 0 3 3 3 0 KaiC AAA_3 PF07726.11 EKE41767.1 - 0.027 14.3 0.1 0.1 12.5 0.0 2.1 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EKE41767.1 - 0.03 14.5 0.3 0.097 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EKE41767.1 - 0.041 13.6 0.2 0.11 12.2 0.2 1.9 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 EKE41767.1 - 0.049 12.8 0.0 0.049 12.8 0.0 1.8 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_17 PF13207.6 EKE41767.1 - 0.067 13.6 0.8 20 5.6 0.6 2.7 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 EKE41767.1 - 0.068 13.3 0.0 0.26 11.4 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EKE41767.1 - 0.081 13.3 0.0 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase DUF724 PF05266.14 EKE41767.1 - 0.11 12.3 5.0 0.41 10.5 5.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TsaE PF02367.17 EKE41767.1 - 0.14 12.2 0.1 0.3 11.1 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EKE41767.1 - 0.2 11.2 0.3 0.6 9.7 0.1 1.8 1 1 1 2 2 2 0 AAA domain eIF2A PF08662.11 EKE41768.1 - 2.6e-33 115.5 4.5 2.6e-32 112.3 1.9 2.7 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Myb_DNA-binding PF00249.31 EKE41769.1 - 1.2e-22 79.8 0.6 6.3e-13 48.7 0.3 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE41769.1 - 6.2e-16 58.4 0.2 7.9e-10 38.8 0.0 2.1 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EKE41769.1 - 3.8e-06 26.9 0.4 0.00076 19.5 0.1 2.3 1 1 1 2 2 2 2 SLIDE Myb_DNA-bind_7 PF15963.5 EKE41769.1 - 0.00067 19.5 0.7 0.0038 17.1 0.2 2.0 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-bind_2 PF08914.11 EKE41769.1 - 0.0024 18.0 0.4 4.3 7.6 0.0 2.9 1 1 1 2 2 2 2 Rap1 Myb domain SANT_DAMP1_like PF16282.5 EKE41769.1 - 0.015 15.4 0.8 0.062 13.5 0.3 2.0 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 ADH_N PF08240.12 EKE41770.1 - 6.8e-28 96.7 4.1 6.8e-28 96.7 4.1 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EKE41770.1 - 1.1e-15 57.8 0.0 1.7e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EKE41770.1 - 0.00066 19.0 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_25 PF13649.6 EKE41770.1 - 0.00091 19.9 0.1 0.0076 16.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 EKE41770.1 - 0.0059 16.2 0.3 0.012 15.2 0.3 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glu_dehyd_C PF16912.5 EKE41770.1 - 0.056 12.9 0.0 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus Methyltransf_18 PF12847.7 EKE41770.1 - 0.088 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain FH2 PF02181.23 EKE41771.1 - 5.7e-68 229.7 10.2 5.7e-68 229.7 10.2 3.8 4 0 0 4 4 4 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 EKE41771.1 - 1.7e-34 119.1 10.7 1.7e-34 119.1 10.7 2.8 2 0 0 2 2 2 1 Diaphanous FH3 Domain Drf_FH1 PF06346.12 EKE41771.1 - 3.6e-15 56.0 124.1 7.4e-15 55.0 124.1 1.5 1 0 0 1 1 1 1 Formin Homology Region 1 Drf_GBD PF06371.13 EKE41771.1 - 9.1e-10 38.4 0.9 9.1e-10 38.4 0.9 2.9 2 0 0 2 2 1 1 Diaphanous GTPase-binding Domain Laminin_II PF06009.12 EKE41771.1 - 0.0001 22.4 8.7 0.0001 22.4 8.7 4.0 4 0 0 4 4 4 2 Laminin Domain II C1_1 PF00130.22 EKE41771.1 - 0.01 15.7 10.5 0.019 14.8 10.5 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RRPl_C4 PF17026.5 EKE41771.1 - 0.012 15.7 8.0 0.048 13.8 8.0 2.1 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type Phage_lysis PF03245.13 EKE41771.1 - 0.033 14.3 0.3 0.033 14.3 0.3 3.0 3 1 0 3 3 2 0 Bacteriophage Rz lysis protein Prok-RING_1 PF14446.6 EKE41771.1 - 0.041 13.8 7.7 0.092 12.7 7.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DUF3800 PF12686.7 EKE41771.1 - 0.047 14.3 0.0 7.7 7.2 0.0 4.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Zn_ribbon_17 PF17120.5 EKE41771.1 - 0.093 12.4 4.4 0.16 11.6 4.4 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type MCPsignal PF00015.21 EKE41771.1 - 6.7 6.5 17.4 2.7 7.8 8.4 3.6 4 0 0 4 4 4 0 Methyl-accepting chemotaxis protein (MCP) signalling domain APG17 PF04108.12 EKE41771.1 - 7 5.6 25.6 3.3 6.7 0.1 4.0 4 0 0 4 4 4 0 Autophagy protein Apg17 FidL_like PF15941.5 EKE41772.1 - 0.082 13.4 0.2 0.31 11.5 0.0 1.8 1 1 1 2 2 2 0 FidL-like putative membrane protein TP6A_N PF04406.14 EKE41773.1 - 4.2e-14 52.3 0.2 1.3e-13 50.7 0.2 2.0 1 0 0 1 1 1 1 Type IIB DNA topoisomerase TLD PF07534.16 EKE41774.1 - 0.00024 21.3 0.5 0.00032 20.9 0.5 1.3 1 0 0 1 1 1 1 TLD DUF4366 PF14283.6 EKE41774.1 - 0.03 14.4 0.5 0.05 13.7 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Mem_trans PF03547.18 EKE41775.1 - 0.0044 15.5 14.4 0.057 11.8 14.4 2.1 1 1 0 1 1 1 1 Membrane transport protein Opi1 PF08618.10 EKE41775.1 - 0.011 15.0 0.4 0.017 14.4 0.4 1.1 1 0 0 1 1 1 0 Transcription factor Opi1 RNA_pol_Rpb1_5 PF04998.17 EKE41776.1 - 4e-83 278.9 2.5 6.7e-83 278.2 2.5 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EKE41776.1 - 2.3e-80 270.3 0.5 2.3e-80 270.3 0.5 2.3 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EKE41776.1 - 5.7e-72 241.4 0.0 1.4e-71 240.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EKE41776.1 - 1.2e-30 106.5 0.1 2.9e-29 102.0 0.0 2.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EKE41776.1 - 1.1e-27 96.1 2.1 3.4e-27 94.5 0.1 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Pkinase PF00069.25 EKE41777.1 - 7.1e-12 45.2 1.9 1.4e-11 44.2 1.9 1.4 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 EKE41777.1 - 4e-10 39.2 0.3 5.8e-10 38.6 0.3 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_Tyr PF07714.17 EKE41777.1 - 8.2e-07 28.6 0.7 3e-05 23.4 0.2 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Choline_kinase PF01633.20 EKE41777.1 - 0.0014 18.3 1.8 0.0024 17.5 1.8 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKE41777.1 - 0.014 15.3 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_2 PF07719.17 EKE41781.1 - 1.5e-14 52.8 9.8 2.4e-06 27.2 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EKE41781.1 - 5.5e-09 35.5 12.4 4.3e-05 23.1 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EKE41781.1 - 3.2e-08 33.4 3.2 0.015 15.6 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EKE41781.1 - 1.7e-07 30.8 1.8 0.00065 19.3 0.2 3.2 1 1 2 3 3 3 3 TPR repeat Fis1_TPR_C PF14853.6 EKE41781.1 - 4.3e-05 23.5 0.3 0.00029 20.8 0.1 2.3 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 EKE41781.1 - 4.5e-05 23.3 12.9 5.9e-05 23.0 0.3 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EKE41781.1 - 0.00039 20.7 3.1 0.53 10.6 0.3 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EKE41781.1 - 0.0098 16.4 0.1 0.081 13.4 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EKE41781.1 - 0.015 15.1 0.5 0.72 9.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EKE41781.1 - 0.037 14.8 0.0 0.23 12.4 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat HTH_Tnp_Tc5 PF03221.16 EKE41781.1 - 0.15 12.1 0.8 8.4 6.5 0.1 2.7 2 1 0 2 2 2 0 Tc5 transposase DNA-binding domain TPR_16 PF13432.6 EKE41781.1 - 0.16 12.6 0.0 25 5.6 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat STI1 PF17830.1 EKE41781.1 - 0.17 11.8 24.5 1.1 9.3 20.1 2.7 1 1 2 3 3 3 0 STI1 domain GerD PF17898.1 EKE41781.1 - 0.35 10.8 20.4 0.78 9.7 12.2 3.3 1 1 2 3 3 3 0 Spore germination GerD central core domain DUF3492 PF11997.8 EKE41781.1 - 0.38 10.5 7.4 5 6.8 3.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3492) TPR_21 PF09976.9 EKE41781.1 - 1.2 8.9 6.5 1.7 8.3 0.2 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain RXLR_WY PF18634.1 EKE41781.1 - 2.6 8.1 8.3 9.7 6.2 1.0 3.3 1 1 2 3 3 3 0 RXLR phytopathogen effector protein WY-domain VPS9 PF02204.18 EKE41782.1 - 1.4e-10 41.3 5.7 1.4e-10 41.3 5.7 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain UBX PF00789.20 EKE41783.1 - 9.2e-06 25.8 0.0 2.7e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 UBX domain CLPTM1 PF05602.12 EKE41783.1 - 0.92 8.4 8.1 1.2 8.0 8.1 1.2 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) Latrophilin PF02354.16 EKE41783.1 - 4.7 6.2 10.8 5.7 5.9 10.8 1.2 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region Presenilin PF01080.17 EKE41783.1 - 5.2 5.7 14.5 6.2 5.5 14.5 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EKE41783.1 - 7.9 5.6 5.1 9.5 5.3 5.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter GP44 PF17510.2 EKE41784.1 - 0.044 14.0 0.1 0.26 11.6 0.0 2.0 2 0 0 2 2 2 0 Gene product 44 BURP PF03181.15 EKE41784.1 - 1.1 8.8 3.6 2.4 7.7 0.1 2.7 2 1 1 3 3 3 0 BURP domain DUF4522 PF15022.6 EKE41785.1 - 0.02 15.1 3.2 0.096 13.0 1.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4522) MitMem_reg PF13012.6 EKE41785.1 - 0.1 13.0 3.2 0.15 12.5 3.2 1.5 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function ATP-synt_G PF04718.15 EKE41785.1 - 0.4 11.5 6.3 0.82 10.5 3.7 2.2 1 1 1 2 2 2 0 Mitochondrial ATP synthase g subunit YqfQ PF14181.6 EKE41785.1 - 0.48 10.6 3.9 0.75 10.0 3.9 1.3 1 0 0 1 1 1 0 YqfQ-like protein 60KD_IMP PF02096.20 EKE41785.1 - 1.5 8.7 5.4 1.2 9.0 3.9 1.6 1 1 1 2 2 2 0 60Kd inner membrane protein WD40 PF00400.32 EKE41787.1 - 0.00051 20.8 1.8 1.1 10.3 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat PQQ_2 PF13360.6 EKE41787.1 - 0.0026 17.4 0.0 0.45 10.1 0.0 3.3 3 1 1 4 4 4 2 PQQ-like domain Torus PF16131.5 EKE41788.1 - 4.8e-26 91.6 0.8 4.8e-26 91.6 0.8 2.0 2 1 0 2 2 2 1 Torus domain RRM_1 PF00076.22 EKE41788.1 - 1.4e-06 28.1 0.0 4e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE41788.1 - 0.0032 17.5 0.0 0.0065 16.4 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Fib_alpha PF08702.10 EKE41788.1 - 2.4 8.3 8.1 4.2 7.6 8.1 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Rad10 PF03834.14 EKE41789.1 - 1.5e-20 73.4 4.6 3e-20 72.3 4.6 1.5 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_2 PF12826.7 EKE41789.1 - 0.00031 20.8 0.0 0.00077 19.5 0.0 1.7 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EKE41789.1 - 0.0022 18.6 0.0 0.0045 17.6 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain Peptidase_C1 PF00112.23 EKE41790.1 - 3e-40 138.6 1.5 4.1e-40 138.2 1.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C10 PF01640.17 EKE41790.1 - 0.0041 17.5 0.1 0.014 15.8 0.0 1.7 1 1 1 2 2 2 1 Peptidase C10 family Peptidase_C1_2 PF03051.15 EKE41790.1 - 0.05 12.4 0.0 0.11 11.2 0.0 1.5 1 0 0 1 1 1 0 Peptidase C1-like family Imm59 PF15597.6 EKE41791.1 - 0.17 12.4 2.5 0.2 12.2 1.0 1.8 2 0 0 2 2 2 0 Immunity protein 59 Pentapeptide_4 PF13599.6 EKE41792.1 - 0.51 10.5 2.7 5.6 7.2 0.0 3.7 4 0 0 4 4 4 0 Pentapeptide repeats (9 copies) Utp21 PF04192.12 EKE41793.1 - 2.2e-21 76.4 11.4 2.3e-21 76.4 9.0 2.1 2 1 0 2 2 2 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 EKE41793.1 - 2.9e-16 59.5 0.5 0.00094 19.4 0.1 5.5 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EKE41793.1 - 1.2e-06 29.1 11.7 8.3e-05 23.3 0.1 6.4 8 0 0 8 8 8 1 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EKE41793.1 - 1.5e-05 23.7 0.1 4e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 Cytochrome D1 heme domain Utp12 PF04003.12 EKE41793.1 - 0.00017 21.9 0.2 0.00033 20.9 0.2 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family BBS2_Mid PF14783.6 EKE41793.1 - 0.019 15.0 0.7 0.4 10.7 0.0 3.2 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region UTP15_C PF09384.10 EKE41793.1 - 0.04 13.6 1.2 0.063 13.0 0.5 1.6 2 0 0 2 2 2 0 UTP15 C terminal PQQ_2 PF13360.6 EKE41793.1 - 0.17 11.5 0.0 1.8 8.1 0.0 2.5 3 1 0 3 3 3 0 PQQ-like domain HSP70 PF00012.20 EKE41794.1 - 2.1e-233 775.9 11.1 2.7e-233 775.5 11.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE41794.1 - 7.1e-15 54.6 3.7 1.7e-13 50.1 0.0 2.6 3 0 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.6 EKE41794.1 - 0.012 16.0 2.7 2.3 8.7 0.0 3.3 3 2 0 3 3 3 0 Cell division protein FtsA FGGY_C PF02782.16 EKE41794.1 - 0.033 13.9 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 EKE41794.1 - 0.062 12.6 0.7 0.3 10.3 0.1 2.3 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase CENP-X PF09415.10 EKE41794.1 - 0.37 11.1 4.5 0.35 11.2 1.8 2.4 2 0 0 2 2 2 0 CENP-S associating Centromere protein X AAA_11 PF13086.6 EKE41794.1 - 0.82 9.4 4.6 1.8 8.3 3.5 2.0 2 0 0 2 2 2 0 AAA domain SspB PF04386.13 EKE41795.1 - 3 7.7 7.7 4.6 7.1 7.7 1.3 1 0 0 1 1 1 0 Stringent starvation protein B PNTB PF02233.16 EKE41797.1 - 1.1e-46 159.7 7.0 1.4e-46 159.4 7.0 1.0 1 0 0 1 1 1 1 NAD(P) transhydrogenase beta subunit Glyco_transf_7N PF13733.6 EKE41797.1 - 0.0085 15.7 0.8 0.49 10.0 0.4 2.3 2 0 0 2 2 2 2 N-terminal region of glycosyl transferase group 7 PP2C_2 PF13672.6 EKE41798.1 - 2.2e-06 27.5 0.0 4.3e-06 26.5 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C Pkinase PF00069.25 EKE41799.1 - 5.5e-09 35.8 0.0 9.4e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain HTH_54 PF18607.1 EKE41799.1 - 0.1 12.6 0.4 20 5.3 0.0 2.4 1 1 1 2 2 2 0 ParA helix turn helix domain Thioredoxin PF00085.20 EKE41800.1 - 2.8e-16 59.4 0.0 3.3e-16 59.1 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 EKE41800.1 - 0.0009 19.0 0.0 0.001 18.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EKE41800.1 - 0.0089 16.3 0.5 1.5 9.2 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like DIM1 PF02966.16 EKE41800.1 - 0.019 14.8 0.0 0.021 14.6 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 Thioredoxin_2 PF13098.6 EKE41800.1 - 0.022 15.2 0.4 0.15 12.5 0.4 1.9 1 1 0 1 1 1 0 Thioredoxin-like domain DUF953 PF06110.11 EKE41800.1 - 0.034 13.7 0.1 0.24 11.0 0.1 2.0 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) OST3_OST6 PF04756.13 EKE41800.1 - 0.05 12.9 0.0 0.058 12.7 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 EKE41800.1 - 0.056 13.5 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Glutaredoxin PF00462.24 EKE41800.1 - 0.086 13.1 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin AhpC-TSA PF00578.21 EKE41800.1 - 0.1 12.5 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family RhoGEF PF00621.20 EKE41801.1 - 6.6e-31 108.0 4.9 1.7e-30 106.6 4.9 1.7 1 0 0 1 1 1 1 RhoGEF domain FAM184 PF15665.5 EKE41802.1 - 0.0046 16.8 35.1 0.0046 16.8 35.1 2.1 1 1 1 2 2 2 1 Family with sequence similarity 184, A and B LPP PF04728.13 EKE41802.1 - 0.02 15.3 7.6 2.4 8.6 0.4 4.1 3 2 0 3 3 3 0 Lipoprotein leucine-zipper DUF4200 PF13863.6 EKE41802.1 - 0.021 15.2 30.6 0.021 15.2 30.6 3.9 1 1 2 4 4 3 0 Domain of unknown function (DUF4200) ApoO PF09769.9 EKE41802.1 - 0.074 13.0 4.7 0.11 12.5 0.1 2.9 2 2 1 3 3 3 0 Apolipoprotein O Baculo_PEP_C PF04513.12 EKE41802.1 - 0.17 11.9 6.4 0.088 12.9 0.6 2.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus MCC-bdg_PDZ PF10506.9 EKE41802.1 - 0.23 11.5 14.3 2.3 8.3 0.4 3.8 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF4618 PF15397.6 EKE41802.1 - 0.24 10.8 34.4 0.064 12.7 14.5 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4618) NPV_P10 PF05531.12 EKE41802.1 - 0.27 11.7 10.3 0.089 13.3 4.6 3.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Fungal_trans_2 PF11951.8 EKE41802.1 - 1 8.1 7.0 0.96 8.2 0.4 2.1 2 0 0 2 2 2 0 Fungal specific transcription factor domain DUF4795 PF16043.5 EKE41802.1 - 1.1 8.8 43.6 12 5.4 4.2 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) HMMR_N PF15905.5 EKE41802.1 - 1.1 8.6 46.4 0.23 10.9 25.6 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF4407 PF14362.6 EKE41802.1 - 1.3 8.3 23.9 2.5 7.4 11.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ERM PF00769.19 EKE41802.1 - 1.4 8.7 47.1 0.31 10.8 22.4 2.7 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF3153 PF11353.8 EKE41802.1 - 2.1 7.9 8.3 0.59 9.7 2.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3153) ADIP PF11559.8 EKE41802.1 - 2.7 8.1 40.6 0.45 10.6 0.9 3.6 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 EKE41802.1 - 3.2 6.5 44.3 2.3 7.0 8.6 2.7 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF3584 PF12128.8 EKE41802.1 - 3.9 4.9 37.1 33 1.8 37.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) FapA PF03961.13 EKE41802.1 - 4.5 5.8 36.5 1.2 7.7 11.7 2.2 1 1 1 2 2 2 0 Flagellar Assembly Protein A Atg14 PF10186.9 EKE41802.1 - 6.7 5.7 31.7 1.3 8.0 6.7 2.4 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Jnk-SapK_ap_N PF09744.9 EKE41802.1 - 8.7 6.6 48.9 15 5.8 2.3 3.3 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 GBP_C PF02841.14 EKE41802.1 - 9.6 5.5 36.4 0.4 10.0 8.8 2.3 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain DEAD PF00270.29 EKE41803.1 - 3.9e-48 163.5 0.0 3.9e-48 163.5 0.0 2.6 4 0 0 4 4 4 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE41803.1 - 1.4e-28 99.4 0.1 5.3e-27 94.4 0.0 3.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DNA_pol3_chi PF04364.13 EKE41803.1 - 0.031 14.4 0.3 0.15 12.3 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase III chi subunit, HolC Ras PF00071.22 EKE41804.1 - 1.2e-33 116.0 0.2 1.4e-33 115.7 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41804.1 - 3.4e-15 56.3 0.0 5.8e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41804.1 - 1.9e-11 43.8 0.0 2.2e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE41804.1 - 3.1e-08 33.4 0.0 3.8e-06 26.6 0.0 2.2 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE41804.1 - 4.8e-08 33.1 0.1 8.2e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE41804.1 - 5.9e-06 25.8 0.4 1e-05 25.1 0.2 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EKE41804.1 - 0.0018 17.8 0.9 0.0029 17.2 0.2 1.8 1 1 1 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EKE41804.1 - 0.012 15.6 0.4 3.9 7.3 0.0 2.4 1 1 1 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 EKE41804.1 - 0.031 14.0 0.3 0.13 12.0 0.2 2.3 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EKE41804.1 - 0.052 12.9 0.0 0.27 10.6 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein TRAPP PF04051.16 EKE41805.1 - 4.9e-22 78.2 0.1 5.9e-22 78.0 0.1 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Pkinase PF00069.25 EKE41806.1 - 9.4e-68 228.4 0.9 1.3e-67 227.9 0.9 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41806.1 - 7.1e-40 136.9 0.2 1e-39 136.4 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE41806.1 - 1.4e-05 24.6 0.0 2.7e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 EKE41806.1 - 0.0023 17.5 0.8 0.01 15.5 0.2 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.14 EKE41806.1 - 0.0027 17.1 0.1 0.0044 16.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EKE41806.1 - 0.0045 17.0 0.1 0.22 11.4 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Sec23_trunk PF04811.15 EKE41807.1 - 6.9e-17 61.8 4.8 8.1e-17 61.6 0.7 2.9 2 2 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EKE41807.1 - 2.3e-12 47.5 0.0 5.5e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EKE41807.1 - 2.3e-11 43.5 4.1 7.3e-11 41.9 4.1 1.9 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Csm1_N PF18504.1 EKE41808.1 - 0.0044 17.3 43.8 0.0045 17.3 12.2 5.6 1 1 5 6 6 6 2 Csm1 N-terminal domain DUF4201 PF13870.6 EKE41808.1 - 0.0058 16.4 20.9 0.0058 16.4 20.9 3.8 1 1 2 3 3 3 1 Domain of unknown function (DUF4201) bZIP_1 PF00170.21 EKE41808.1 - 0.0065 16.5 2.3 0.0065 16.5 2.3 5.4 4 1 1 5 5 5 2 bZIP transcription factor Golgin_A5 PF09787.9 EKE41808.1 - 0.0094 15.5 37.1 0.022 14.2 37.1 1.6 1 1 0 1 1 1 1 Golgin subfamily A member 5 DivIC PF04977.15 EKE41808.1 - 0.015 15.0 3.3 0.015 15.0 3.3 5.7 3 1 2 5 5 5 0 Septum formation initiator DUF2205 PF10224.9 EKE41808.1 - 0.015 15.2 7.2 0.015 15.2 7.2 4.0 2 1 2 4 4 4 0 Short coiled-coil protein TetR_C_4 PF08359.11 EKE41808.1 - 0.028 14.6 1.6 0.028 14.6 1.6 2.9 2 1 1 3 3 3 0 YsiA-like protein, C-terminal region TolA_bind_tri PF16331.5 EKE41808.1 - 0.035 14.2 0.9 0.035 14.2 0.9 4.1 3 1 0 3 3 2 0 TolA binding protein trimerisation Herpes_BLRF2 PF05812.12 EKE41808.1 - 0.045 13.9 1.1 0.045 13.9 1.1 3.9 2 2 3 5 5 5 0 Herpesvirus BLRF2 protein KLRAQ PF10205.9 EKE41808.1 - 0.31 11.3 33.4 0.24 11.7 10.4 3.7 1 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein Bacillus_HBL PF05791.11 EKE41808.1 - 1.6 8.6 28.5 0.03 14.1 7.9 3.2 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DUF641 PF04859.12 EKE41808.1 - 1.7 8.9 33.7 1.1 9.6 4.7 4.2 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) UPF0242 PF06785.11 EKE41808.1 - 2.3 8.3 42.7 1.1 9.3 26.6 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus NUDIX_2 PF13869.6 EKE41808.1 - 2.5 7.6 13.1 1.3 8.5 10.3 2.0 1 1 1 2 2 2 0 Nucleotide hydrolase HIP1_clath_bdg PF16515.5 EKE41808.1 - 3.3 8.4 34.9 7.3 7.3 10.3 3.7 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fez1 PF06818.15 EKE41808.1 - 3.4 8.1 34.9 29 5.0 23.2 2.9 1 1 1 2 2 2 0 Fez1 DUF4407 PF14362.6 EKE41808.1 - 3.6 6.9 22.7 19 4.5 22.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2968 PF11180.8 EKE41808.1 - 3.6 7.2 24.5 0.12 12.1 4.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) TACC_C PF05010.14 EKE41808.1 - 4.3 7.1 37.8 5 6.9 36.8 1.6 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal APG6_N PF17675.1 EKE41808.1 - 5.9 7.4 40.4 0.14 12.7 6.0 3.3 1 1 1 2 2 1 0 Apg6 coiled-coil region Exonuc_VII_L PF02601.15 EKE41808.1 - 8.3 5.9 21.0 16 4.9 21.0 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit ATG16 PF08614.11 EKE41808.1 - 9.1 6.4 34.8 0.27 11.4 7.5 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DSPc PF00782.20 EKE41809.1 - 3.6e-32 111.0 0.0 1.2e-31 109.3 0.0 1.9 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_4 PF12799.7 EKE41809.1 - 2.8e-10 40.3 14.3 1.7e-05 25.1 0.6 3.9 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE41809.1 - 5e-08 32.6 13.0 0.0002 21.0 3.8 3.8 3 1 0 3 3 3 2 Leucine rich repeat Suppressor_P21 PF11479.8 EKE41809.1 - 0.0021 18.2 4.1 1.4 9.1 0.1 3.5 3 1 1 4 4 4 2 RNA silencing suppressor P21 C-terminal domain LRR_1 PF00560.33 EKE41809.1 - 0.0027 18.0 7.6 27 5.8 0.0 5.4 4 1 0 4 4 4 0 Leucine Rich Repeat Y_phosphatase PF00102.27 EKE41809.1 - 0.031 13.8 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EKE41809.1 - 0.046 13.8 0.4 0.36 10.9 0.0 2.1 2 0 0 2 2 2 0 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 EKE41809.1 - 0.065 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain LRR_6 PF13516.6 EKE41809.1 - 0.079 13.1 9.2 5.3 7.4 0.1 4.6 5 0 0 5 5 5 0 Leucine Rich repeat Ras PF00071.22 EKE41810.1 - 1.5e-32 112.4 0.2 2.2e-32 111.9 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41810.1 - 1.2e-24 86.9 0.1 1.7e-24 86.3 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41810.1 - 3.5e-12 46.1 0.0 5e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 EKE41810.1 - 3e-06 27.0 0.1 5.7e-06 26.1 0.1 1.5 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 EKE41810.1 - 5.7e-06 26.0 0.1 0.00048 19.7 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EKE41810.1 - 6.2e-05 22.6 0.0 0.0022 17.5 0.0 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EKE41810.1 - 0.00022 21.3 0.0 0.00032 20.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE41810.1 - 0.00029 20.8 0.0 0.74 9.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EKE41810.1 - 0.0013 18.1 0.1 0.0016 17.8 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1_Xtn PF16897.5 EKE41810.1 - 0.0052 16.8 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TniB PF05621.11 EKE41810.1 - 0.01 15.3 0.0 0.09 12.2 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 EKE41810.1 - 0.017 15.5 0.0 0.053 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 EKE41810.1 - 0.049 13.1 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 EKE41810.1 - 0.05 13.0 0.0 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit TsaE PF02367.17 EKE41810.1 - 0.051 13.6 0.0 0.077 13.0 0.0 1.4 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EKE41810.1 - 0.066 12.4 0.0 0.086 12.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.6 EKE41810.1 - 0.074 13.3 0.0 0.12 12.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 EKE41810.1 - 0.14 11.4 0.2 0.29 10.4 0.2 1.4 1 0 0 1 1 1 0 KaiC DNA_pol_A_exo1 PF01612.20 EKE41811.1 - 9.5e-12 45.0 0.1 1.9e-11 44.0 0.0 1.5 2 0 0 2 2 2 1 3'-5' exonuclease Radial_spoke_3 PF06098.11 EKE41811.1 - 0.1 11.9 6.2 0.15 11.3 6.2 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 FtsX PF02687.21 EKE41812.1 - 7e-15 55.3 30.0 9e-11 42.1 11.6 6.6 6 1 1 7 7 7 3 FtsX-like permease family MotB_plug PF13677.6 EKE41812.1 - 0.055 13.1 1.8 0.19 11.4 1.8 1.9 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB TRIQK PF15168.6 EKE41812.1 - 6.5 6.7 10.5 0.087 12.7 0.9 2.9 3 0 0 3 3 3 0 Triple QxxK/R motif-containing protein family PI3_PI4_kinase PF00454.27 EKE41814.1 - 3.8e-39 135.0 0.5 2.4e-36 125.8 0.1 3.0 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EKE41814.1 - 1.3e-20 73.6 0.7 1.3e-20 73.6 0.7 3.4 4 0 0 4 4 4 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) TAN PF11640.8 EKE41814.1 - 0.0046 17.1 2.0 1.6 8.8 0.2 3.5 2 1 0 2 2 2 2 Telomere-length maintenance and DNA damage repair DUF4135 PF13575.6 EKE41814.1 - 0.025 13.9 0.0 0.052 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF3385 PF11865.8 EKE41814.1 - 2 8.3 14.9 0.03 14.2 0.7 4.1 4 2 1 5 5 5 0 Domain of unknown function (DUF3385) Telomerase_RBD PF12009.8 EKE41814.1 - 3.8 7.6 9.7 23 5.1 0.4 3.9 3 0 0 3 3 3 0 Telomerase ribonucleoprotein complex - RNA binding domain Polyhedrin PF00738.18 EKE41815.1 - 0.049 13.0 0.1 0.096 12.0 0.1 1.4 1 0 0 1 1 1 0 Polyhedrin FHA PF00498.26 EKE41816.1 - 4.9e-07 30.0 0.1 1e-06 29.0 0.1 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EKE41816.1 - 0.015 15.6 0.0 0.027 14.8 0.0 1.4 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain OTCace_N PF02729.21 EKE41816.1 - 0.048 13.7 1.2 0.078 13.0 0.3 1.7 1 1 1 2 2 2 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain FlgM PF04316.13 EKE41816.1 - 0.19 12.1 1.5 0.45 10.9 0.2 2.2 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM Peptidase_S49_N PF08496.10 EKE41816.1 - 2.8 8.0 5.9 4.9 7.2 5.9 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal ICL PF00463.21 EKE41817.1 - 0.068 11.7 0.0 0.09 11.2 0.0 1.1 1 0 0 1 1 1 0 Isocitrate lyase family SIR2 PF02146.17 EKE41820.1 - 6e-50 169.6 0.0 2.2e-49 167.8 0.0 1.8 2 0 0 2 2 2 1 Sir2 family TPP_enzyme_M PF00205.22 EKE41820.1 - 0.073 12.8 0.0 14 5.4 0.0 2.5 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain AsiA PF09010.10 EKE41820.1 - 0.087 13.0 0.4 0.44 10.7 0.0 2.2 2 0 0 2 2 2 0 Anti-Sigma Factor A DUF2293 PF10056.9 EKE41820.1 - 0.16 12.2 0.0 0.43 10.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2293) HSF_DNA-bind PF00447.17 EKE41821.1 - 1.5e-05 25.5 2.7 3.2e-05 24.5 2.7 1.8 1 1 0 1 1 1 1 HSF-type DNA-binding CsgF PF10614.9 EKE41821.1 - 0.13 12.5 3.5 0.22 11.8 3.5 1.3 1 0 0 1 1 1 0 Type VIII secretion system (T8SS), CsgF protein DUF3676 PF12429.8 EKE41821.1 - 0.22 11.4 4.7 0.3 10.9 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3676) Spore_II_R PF09551.10 EKE41821.1 - 1.2 9.6 9.0 0.093 13.2 3.0 2.1 2 0 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) RNA_pol_Rpb1_5 PF04998.17 EKE41821.1 - 4.8 6.5 7.7 6.9 6.0 7.7 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Rogdi_lz PF10259.9 EKE41822.1 - 5.7e-09 35.8 0.6 7.1e-09 35.5 0.6 1.2 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein SNF2_assoc PF08455.10 EKE41822.1 - 0.011 14.8 0.5 0.018 14.1 0.5 1.3 1 0 0 1 1 1 0 Bacterial SNF2 helicase associated PI3_PI4_kinase PF00454.27 EKE41824.1 - 1.9e-46 158.9 2.6 1.9e-46 158.9 2.6 3.1 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EKE41824.1 - 2.7e-35 121.5 0.4 5.9e-35 120.3 0.4 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 EKE41824.1 - 1.1e-15 57.8 0.4 4.6e-15 55.8 0.0 2.2 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 EKE41824.1 - 0.0023 17.3 0.0 0.0049 16.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) RHH_5 PF07878.11 EKE41824.1 - 0.14 12.1 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 RhoGAP-FF1 PF16512.5 EKE41825.1 - 0.088 13.5 0.2 2.2 9.0 0.1 2.3 2 0 0 2 2 2 0 p190-A and -B Rho GAPs FF domain Acetyltransf_1 PF00583.25 EKE41826.1 - 5.5e-09 36.3 0.9 1.2e-08 35.2 0.9 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EKE41826.1 - 2.7e-08 33.8 0.2 1.1e-06 28.6 0.1 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EKE41826.1 - 8.6e-08 32.5 1.4 3.2e-06 27.5 1.4 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EKE41826.1 - 0.00053 20.1 0.0 0.13 12.4 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 EKE41826.1 - 0.036 14.0 0.0 0.059 13.3 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_15 PF17013.5 EKE41826.1 - 0.19 11.1 12.6 0.31 10.5 12.6 1.5 1 1 0 1 1 1 0 Putative acetyl-transferase DUF3800 PF12686.7 EKE41826.1 - 1 10.0 6.5 2 9.0 6.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF5411 PF17424.2 EKE41827.1 - 0.051 13.5 1.9 1.3 9.0 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5411) ODV-E18 PF10717.9 EKE41827.1 - 0.055 13.3 0.2 0.11 12.3 0.0 1.6 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DUF2985 PF11204.8 EKE41827.1 - 0.066 13.4 3.3 1.2 9.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2985) Mon1 PF03164.14 EKE41828.1 - 4e-88 296.2 16.9 4.5e-88 296.0 16.9 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Peptidase_C39 PF03412.15 EKE41828.1 - 0.0063 16.3 0.5 0.0063 16.3 0.5 2.0 2 0 0 2 2 2 1 Peptidase C39 family LIDHydrolase PF10230.9 EKE41829.1 - 2.2e-36 125.8 3.2 5e-36 124.6 3.2 1.5 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EKE41829.1 - 0.00012 21.4 0.0 0.007 15.7 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 PLDc_2 PF13091.6 EKE41829.1 - 0.0015 18.4 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 PLD-like domain Cutinase PF01083.22 EKE41829.1 - 0.0035 17.3 0.0 0.064 13.2 0.0 2.3 2 0 0 2 2 2 1 Cutinase DUF900 PF05990.12 EKE41829.1 - 0.0075 15.8 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) PS_pyruv_trans PF04230.13 EKE41829.1 - 0.018 15.0 0.4 4 7.3 0.0 2.6 3 0 0 3 3 3 0 Polysaccharide pyruvyl transferase Abhydrolase_5 PF12695.7 EKE41829.1 - 0.038 13.8 0.0 0.087 12.6 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF676 PF05057.14 EKE41829.1 - 0.085 12.4 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Lipase_3 PF01764.25 EKE41829.1 - 0.091 12.6 0.0 0.24 11.3 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 3) Pkinase PF00069.25 EKE41830.1 - 4.2e-44 150.9 0.1 6.7e-43 146.9 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41830.1 - 2.3e-27 95.9 0.0 6.6e-27 94.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EKE41830.1 - 0.011 15.3 0.1 0.021 14.5 0.1 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EKE41830.1 - 0.071 11.9 0.0 0.094 11.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase DUF2838 PF10998.8 EKE41830.1 - 0.084 13.1 0.8 2.3 8.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2838) Mak10 PF04112.13 EKE41832.1 - 0.00015 21.3 2.1 0.00046 19.7 0.1 2.3 1 1 1 2 2 2 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase rRNA_processing PF08524.11 EKE41832.1 - 0.017 15.2 3.5 0.061 13.3 3.5 1.9 1 0 0 1 1 1 0 rRNA processing DUF1246 PF06849.12 EKE41832.1 - 0.42 10.6 3.8 0.95 9.4 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1246) Ras PF00071.22 EKE41833.1 - 1.2e-36 125.8 0.4 1.4e-36 125.6 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41833.1 - 4.3e-20 72.1 0.1 6.9e-20 71.5 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41833.1 - 1.6e-09 37.5 0.1 1.8e-09 37.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE41833.1 - 0.00084 19.3 0.0 0.0011 18.9 0.0 1.1 1 0 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 EKE41833.1 - 0.0027 17.3 0.0 0.0091 15.6 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 EKE41833.1 - 0.042 13.9 0.0 0.056 13.5 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Gtr1_RagA PF04670.12 EKE41833.1 - 0.046 13.1 0.1 0.062 12.6 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE41833.1 - 0.066 13.3 0.0 0.15 12.2 0.0 1.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Herpes_HEPA PF03324.14 EKE41833.1 - 0.11 13.0 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus DNA helicase/primase complex associated protein VSP PF03302.13 EKE41834.1 - 1e-05 24.6 112.3 2.8e-05 23.1 36.3 5.0 1 1 5 6 6 6 4 Giardia variant-specific surface protein MA3 PF02847.17 EKE41835.1 - 1.3e-15 57.4 4.7 4.3e-15 55.7 4.7 2.0 1 0 0 1 1 1 1 MA3 domain Ribonuclease_P PF00825.18 EKE41836.1 - 0.0012 18.9 2.4 0.0012 18.9 2.4 2.2 2 0 0 2 2 2 1 Ribonuclease P CHB_HEX_C PF03174.13 EKE41836.1 - 0.031 14.3 0.2 0.17 11.9 0.1 2.3 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain Baculo_PEP_C PF04513.12 EKE41837.1 - 0.052 13.6 13.1 1.5 8.8 0.3 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Flagellin_C PF00700.21 EKE41837.1 - 0.99 9.8 8.1 0.62 10.5 4.4 2.6 2 0 0 2 2 2 0 Bacterial flagellin C-terminal helical region Gly_radical PF01228.21 EKE41837.1 - 1.5 9.4 9.4 1.2 9.7 3.0 2.8 2 1 0 2 2 2 0 Glycine radical CHAD PF05235.14 EKE41837.1 - 2.2 8.2 11.0 1.3 9.0 8.9 1.6 1 1 0 1 1 1 0 CHAD domain Tweety PF04906.13 EKE41837.1 - 2.7 6.6 10.8 2.6 6.6 1.7 3.2 1 1 1 3 3 3 0 Tweety TetR_C_13 PF16925.5 EKE41837.1 - 2.8 7.9 6.9 3.3 7.7 1.9 2.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Complex1_LYR PF05347.15 EKE41837.1 - 3.2 7.9 6.8 0.89 9.7 0.3 2.7 1 1 1 2 2 2 0 Complex 1 protein (LYR family) AcylCoA_dehyd_C PF12186.8 EKE41837.1 - 9.6 6.4 12.7 2.5 8.2 2.7 3.1 2 1 0 3 3 3 0 Acyl-CoA dehydrogenase C terminal VPS9 PF02204.18 EKE41838.1 - 5.6e-09 36.2 1.7 1.4e-08 34.9 0.7 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain DUF3135 PF11333.8 EKE41838.1 - 0.89 9.8 3.1 51 4.2 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3135) ADK PF00406.22 EKE41839.1 - 1.8e-43 148.2 0.0 2.4e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EKE41839.1 - 2.9e-31 108.7 0.1 4.6e-31 108.1 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EKE41839.1 - 4.6e-07 30.4 0.0 7e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EKE41839.1 - 1.1e-05 25.6 0.0 1.6e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EKE41839.1 - 0.00087 19.0 0.5 0.061 13.0 0.0 2.5 1 1 2 3 3 3 1 Thymidylate kinase SRP54 PF00448.22 EKE41839.1 - 0.02 14.5 0.0 0.062 12.9 0.0 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain tRNA_edit PF04073.15 EKE41841.1 - 0.0011 19.1 0.0 0.0017 18.4 0.0 1.5 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain RhoGEF PF00621.20 EKE41842.1 - 6.8e-28 98.1 4.7 1.5e-27 97.0 4.7 1.6 1 0 0 1 1 1 1 RhoGEF domain Sharpin_PH PF16764.5 EKE41842.1 - 0.0047 16.7 0.0 0.0097 15.7 0.0 1.4 1 0 0 1 1 1 1 Sharpin PH domain SAM_DrpA PF18255.1 EKE41842.1 - 0.041 14.1 0.1 0.22 11.8 0.1 2.4 1 0 0 1 1 1 0 DNA processing protein A sterile alpha motif domain SnoaL_3 PF13474.6 EKE41842.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain Ribosomal_L32e PF01655.18 EKE41843.1 - 4e-44 149.4 0.2 4.8e-44 149.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Tma16 PF11176.8 EKE41844.1 - 1.6e-14 54.0 0.9 1.9e-14 53.8 0.9 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 Atg14 PF10186.9 EKE41845.1 - 1.7e-06 27.4 16.0 2.7e-06 26.7 16.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Thioredoxin_14 PF18402.1 EKE41845.1 - 0.0063 16.5 6.1 0.012 15.6 6.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain kleA_kleC PF17383.2 EKE41845.1 - 0.0067 16.7 1.1 0.0067 16.7 1.1 2.9 1 1 2 3 3 3 1 Uncharacterized KorC regulated protein A DUF1995 PF09353.10 EKE41845.1 - 0.1 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1995) OmpH PF03938.14 EKE41845.1 - 2.2 8.6 21.5 26 5.2 7.8 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) NYD-SP28_assoc PF14775.6 EKE41845.1 - 8.4 6.6 11.2 5.9 7.1 2.3 2.9 2 0 0 2 2 2 0 Sperm tail C-terminal domain PNP_UDP_1 PF01048.20 EKE41846.1 - 9.1e-30 103.6 0.0 1.2e-29 103.3 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily TcpE PF12648.7 EKE41847.1 - 0.52 10.9 9.5 0.68 10.5 6.8 2.2 1 1 1 2 2 2 0 TcpE family COX8 PF02285.15 EKE41847.1 - 0.99 9.3 3.6 5.6 6.9 0.0 3.3 3 0 0 3 3 3 0 Cytochrome oxidase c subunit VIII PARP PF00644.20 EKE41848.1 - 6.1e-53 179.3 0.0 1.9e-52 177.7 0.0 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EKE41848.1 - 5.7e-28 97.7 5.5 1.3e-27 96.6 5.5 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain PADR1 PF08063.12 EKE41848.1 - 4.9e-17 61.5 0.2 4.9e-17 61.5 0.2 2.4 2 0 0 2 2 2 1 PADR1 (NUC008) domain zf-PARP PF00645.18 EKE41848.1 - 2.9e-11 44.1 1.2 1.4e-10 41.8 1.2 2.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region WGR PF05406.15 EKE41848.1 - 1.1e-08 35.0 1.1 1.1e-08 35.0 1.1 2.6 3 0 0 3 3 3 1 WGR domain BRCT_2 PF16589.5 EKE41848.1 - 2.2e-05 24.7 0.0 8.2e-05 22.9 0.0 2.0 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EKE41848.1 - 0.018 15.4 0.5 0.12 12.7 0.0 2.7 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain RNA_ligase PF09414.10 EKE41848.1 - 0.019 15.3 0.0 0.065 13.5 0.0 2.0 1 0 0 1 1 1 0 RNA ligase APG9 PF04109.16 EKE41849.1 - 4.7e-12 45.7 10.5 1.2e-07 31.2 2.2 2.1 2 0 0 2 2 2 2 Autophagy protein Apg9 BOFC_N PF08977.10 EKE41849.1 - 0.044 13.8 0.7 0.23 11.5 0.2 2.4 2 0 0 2 2 2 0 Bypass of Forespore C, N terminal DUF2258 PF10015.9 EKE41849.1 - 0.093 12.9 0.3 0.34 11.1 0.3 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) TMEM208_SND2 PF05620.11 EKE41849.1 - 3.3 7.5 8.7 2.4 7.9 0.2 2.8 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 Rhodanese PF00581.20 EKE41850.1 - 2.3e-06 28.1 0.0 2.9e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain SMC_N PF02463.19 EKE41850.1 - 0.16 11.4 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain NAP PF00956.18 EKE41851.1 - 2.6e-21 76.0 0.2 2.6e-21 76.0 0.2 2.3 1 1 1 2 2 2 1 Nucleosome assembly protein (NAP) CBM64 PF18666.1 EKE41851.1 - 0.053 13.6 0.1 0.096 12.8 0.1 1.4 1 0 0 1 1 1 0 Carbohydrate-binding module 64 LRR_5 PF13306.6 EKE41852.1 - 1e-07 32.0 30.6 4.9e-07 29.8 10.1 4.4 1 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) CAP_C PF08603.11 EKE41852.1 - 0.079 12.6 10.7 0.38 10.4 0.1 3.8 3 1 1 4 4 4 0 Adenylate cyclase associated (CAP) C terminal LRR_6 PF13516.6 EKE41852.1 - 2.3 8.5 8.5 4.9 7.5 0.3 5.5 7 0 0 7 7 7 0 Leucine Rich repeat LRR_4 PF12799.7 EKE41852.1 - 3.3 8.3 43.5 0.16 12.4 2.5 8.1 6 3 1 8 8 8 0 Leucine Rich repeats (2 copies) RhoGEF PF00621.20 EKE41853.1 - 9.2e-40 136.8 5.5 1.3e-39 136.3 2.6 2.0 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 EKE41853.1 - 5.2e-16 58.6 8.2 1.1e-15 57.5 8.2 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EKE41853.1 - 3.8e-07 30.6 0.0 9.5e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 PH domain FYVE_2 PF02318.16 EKE41853.1 - 0.00053 20.2 3.1 0.0015 18.7 3.1 1.8 1 0 0 1 1 1 1 FYVE-type zinc finger PH_13 PF16652.5 EKE41853.1 - 0.0023 17.8 1.5 0.04 13.7 0.5 2.4 1 1 1 2 2 2 1 Pleckstrin homology domain PH_16 PF17838.1 EKE41853.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 PH domain zf-B_box PF00643.24 EKE41853.1 - 7.6 6.8 11.6 24 5.2 11.6 1.8 1 1 0 1 1 1 0 B-box zinc finger E1_DerP2_DerF2 PF02221.15 EKE41854.1 - 1e-10 42.2 0.0 1.1e-10 42.0 0.0 1.0 1 0 0 1 1 1 1 ML domain AdoHcyase PF05221.17 EKE41855.1 - 1e-140 468.1 0.0 1.2e-140 467.9 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EKE41855.1 - 6e-83 276.7 2.4 9.4e-83 276.1 2.4 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EKE41855.1 - 6.8e-07 28.8 0.1 1.2e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EKE41855.1 - 0.00021 20.9 0.1 0.00041 20.0 0.1 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EKE41855.1 - 0.00056 20.1 0.1 0.0016 18.7 0.1 1.9 1 1 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.20 EKE41855.1 - 0.00092 19.3 0.0 0.053 13.6 0.1 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EKE41855.1 - 0.0016 18.9 0.4 0.0036 17.7 0.4 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Ras PF00071.22 EKE41856.1 - 8.8e-41 139.2 0.1 8.8e-41 139.2 0.1 1.7 1 1 1 2 2 2 1 Ras family Roc PF08477.13 EKE41856.1 - 1.3e-20 73.8 0.4 4.8e-20 72.0 0.0 2.0 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41856.1 - 8.5e-10 38.4 0.5 3e-09 36.6 0.0 1.8 1 1 1 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE41856.1 - 0.0051 16.9 0.7 0.035 14.2 0.7 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE41856.1 - 0.0083 15.5 0.0 0.0083 15.5 0.0 1.8 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region SKA1 PF07160.12 EKE41856.1 - 0.22 11.4 14.1 0.098 12.5 11.6 1.6 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF1043 PF06295.12 EKE41856.1 - 5.8 6.9 10.5 11 6.1 10.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) O-antigen_lig PF13425.6 EKE41856.1 - 6.3 5.5 5.6 7.6 5.2 5.6 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein LMBR1 PF04791.16 EKE41856.1 - 6.6 5.5 6.3 7.1 5.4 6.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein zf-MIZ PF02891.20 EKE41858.1 - 8.8e-06 25.4 4.1 1.9e-05 24.3 4.1 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger Zap1_zf2 PF18217.1 EKE41858.1 - 0.055 13.5 0.4 0.13 12.3 0.4 1.6 1 0 0 1 1 1 0 Zap1 zinc finger 2 LRR_5 PF13306.6 EKE41859.1 - 6.4e-48 161.9 49.2 1.9e-29 102.2 17.5 7.2 5 3 2 7 7 7 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE41859.1 - 1.1e-12 47.5 14.8 2.2e-05 24.1 0.2 6.1 3 1 3 6 6 6 4 Leucine rich repeat MIG-14_Wnt-bd PF06664.12 EKE41860.1 - 6.7e-36 124.0 37.8 6.7e-36 124.0 37.8 1.7 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion MscS_TM PF12794.7 EKE41860.1 - 0.14 11.0 11.6 0.66 8.8 7.2 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Acetyltransf_1 PF00583.25 EKE41861.1 - 8.5e-11 42.1 0.4 1.1e-10 41.7 0.4 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EKE41861.1 - 1.2e-07 31.8 0.1 1.2e-07 31.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EKE41861.1 - 4.9e-07 29.6 0.0 7.4e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EKE41861.1 - 4.7e-05 23.7 0.1 6.7e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EKE41861.1 - 0.011 15.9 1.3 0.014 15.5 1.3 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Bclx_interact PF08945.10 EKE41861.1 - 0.19 11.6 0.5 0.5 10.2 0.5 1.7 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain Hexokinase_2 PF03727.16 EKE41862.1 - 2e-51 174.8 0.1 2.3e-51 174.5 0.1 1.0 1 0 0 1 1 1 1 Hexokinase adh_short_C2 PF13561.6 EKE41862.1 - 0.028 14.0 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase RRM_1 PF00076.22 EKE41863.1 - 1.2e-22 79.5 3.2 7.9e-07 28.8 0.0 5.1 5 1 0 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lipl32 PF12103.8 EKE41863.1 - 0.46 10.1 3.0 1.8 8.2 3.0 1.9 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order RabGAP-TBC PF00566.18 EKE41864.1 - 3.1e-20 72.7 3.9 3.8e-20 72.5 3.9 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain REV PF00424.18 EKE41866.1 - 0.28 11.2 5.1 0.057 13.4 1.1 1.9 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Frag1 PF10277.9 EKE41867.1 - 7.3e-08 32.2 28.2 9.7e-08 31.8 28.2 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Cation_ATPase_C PF00689.21 EKE41867.1 - 0.59 9.8 24.5 0.29 10.8 15.6 2.2 1 1 1 2 2 2 0 Cation transporting ATPase, C-terminus DUF2663 PF10864.8 EKE41867.1 - 7.1 7.1 11.3 0.58 10.6 0.7 3.0 2 1 2 4 4 4 0 Protein of unknown function (DUF2663) Phage_TAC_1 PF06222.11 EKE41870.1 - 0.078 12.7 0.0 0.69 9.7 0.0 2.0 2 0 0 2 2 2 0 Phage tail assembly chaperone PIG-P PF08510.12 EKE41871.1 - 6.7e-15 55.1 0.1 8.5e-15 54.7 0.1 1.1 1 0 0 1 1 1 1 PIG-P Wzy_C PF04932.15 EKE41871.1 - 0.012 15.3 0.1 0.014 15.0 0.1 1.1 1 0 0 1 1 1 0 O-Antigen ligase DUF2207 PF09972.9 EKE41871.1 - 0.075 11.8 0.0 0.089 11.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) NADH_oxidored PF08040.11 EKE41871.1 - 0.15 11.8 0.6 0.32 10.7 0.6 1.5 1 0 0 1 1 1 0 MNLL subunit MutL_C PF08676.11 EKE41872.1 - 1.9e-14 53.6 0.1 3.9e-14 52.7 0.1 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain PI_PP_C PF18365.1 EKE41874.1 - 0.026 14.5 2.5 0.06 13.3 1.9 2.0 1 1 0 1 1 1 0 Phosphoinositide phosphatase C-terminal domain Speriolin_C PF15059.6 EKE41874.1 - 0.12 12.5 1.4 0.43 10.7 1.4 2.0 1 0 0 1 1 1 0 Speriolin C-terminus MRP-S32 PF10210.9 EKE41875.1 - 0.0076 16.8 6.1 0.0076 16.8 6.1 6.5 3 2 3 7 7 7 2 Mitochondrial 28S ribosomal protein S32 Aminotran_1_2 PF00155.21 EKE41876.1 - 3.7e-37 128.3 0.0 4.8e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EKE41876.1 - 0.034 13.4 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase VSP PF03302.13 EKE41877.1 - 6.7e-07 28.5 41.8 6.7e-07 28.5 41.8 2.0 1 1 1 2 2 2 2 Giardia variant-specific surface protein Orf78 PF06024.12 EKE41877.1 - 0.067 13.5 0.3 0.14 12.5 0.3 1.4 1 0 0 1 1 1 0 Orf78 (ac78) stn_TNFRSF12A PF12191.8 EKE41877.1 - 0.14 12.3 0.5 0.43 10.8 0.0 1.9 2 0 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain IF4E PF01652.18 EKE41878.1 - 1e-26 93.6 0.2 1.1e-26 93.5 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E zf-C3HC4_3 PF13920.6 EKE41881.1 - 5.1e-11 42.2 13.6 6.7e-11 41.9 13.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EKE41881.1 - 3.3e-10 40.1 16.4 4.5e-10 39.7 16.4 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKE41881.1 - 5.6e-10 38.9 15.6 7.6e-10 38.5 15.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE41881.1 - 4.6e-08 32.8 16.0 7.4e-08 32.1 16.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EKE41881.1 - 5.9e-06 26.5 14.6 1.7e-05 25.0 14.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EKE41881.1 - 8.4e-06 25.7 12.8 8.9e-06 25.6 10.1 2.0 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EKE41881.1 - 1.4e-05 24.9 13.3 2e-05 24.3 13.3 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EKE41881.1 - 2.1e-05 24.4 13.9 3.3e-05 23.8 13.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Rtf2 PF04641.12 EKE41881.1 - 0.00061 19.2 1.3 0.00074 19.0 1.3 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 EKE41881.1 - 0.015 15.5 14.4 0.071 13.3 14.8 1.8 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EKE41881.1 - 0.15 11.9 16.3 0.089 12.5 12.2 2.3 2 1 0 2 2 2 0 RING-like zinc finger zf-ANAPC11 PF12861.7 EKE41881.1 - 0.22 11.6 8.2 0.34 11.0 8.2 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 EKE41881.1 - 0.56 10.4 11.3 0.72 10.0 10.9 1.4 1 1 0 1 1 1 0 zinc RING finger of MSL2 Stealth_CR1 PF17101.5 EKE41882.1 - 0.00024 20.8 4.9 0.00024 20.8 4.9 1.9 2 0 0 2 2 2 1 Stealth protein CR1, conserved region 1 PAP_assoc PF03828.19 EKE41883.1 - 1.7e-09 37.8 0.1 3.7e-09 36.7 0.1 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase PatG_D PF18047.1 EKE41883.1 - 0.048 14.1 0.0 0.088 13.2 0.0 1.4 1 0 0 1 1 1 0 PatG Domain MutS_V PF00488.21 EKE41884.1 - 1e-76 257.2 0.2 2.7e-76 255.8 0.2 1.7 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EKE41884.1 - 7.9e-27 94.7 9.8 7.1e-26 91.6 9.8 2.3 1 1 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 EKE41884.1 - 4.8e-09 36.4 6.7 4.8e-09 36.4 6.7 2.8 2 0 0 2 2 2 1 MutS family domain IV AAA_27 PF13514.6 EKE41884.1 - 0.002 17.7 0.1 0.0073 15.9 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EKE41884.1 - 0.04 14.4 0.1 0.04 14.4 0.1 3.9 3 1 1 4 4 4 0 AAA domain DUF4373 PF14297.6 EKE41884.1 - 0.5 11.2 7.1 0.8 10.5 0.1 4.1 4 1 1 5 5 5 0 Domain of unknown function (DUF4373) APC1_C PF18122.1 EKE41885.1 - 0.0069 16.4 0.3 0.013 15.4 0.3 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex sub unit 1 C-terminal domain F-box-like_2 PF13013.6 EKE41885.1 - 0.5 10.4 3.3 3.1 7.8 1.6 3.0 2 1 0 2 2 2 0 F-box-like domain DCP1 PF06058.13 EKE41886.1 - 0.00038 20.4 0.1 0.00059 19.8 0.1 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family DUF3826 PF12875.7 EKE41886.1 - 0.058 13.5 0.1 0.089 12.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) Ras PF00071.22 EKE41887.1 - 3.7e-55 186.0 0.2 4.3e-55 185.7 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41887.1 - 1.5e-34 118.8 0.1 2.1e-34 118.3 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41887.1 - 3.7e-21 75.3 0.0 4.6e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE41887.1 - 2.9e-07 30.1 0.0 3.7e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE41887.1 - 8.1e-07 29.1 0.1 0.0028 17.6 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EKE41887.1 - 1e-06 28.3 0.0 1.3e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EKE41887.1 - 1.2e-06 28.4 0.1 1.7e-05 24.6 0.1 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EKE41887.1 - 1.6e-06 28.2 0.0 1.1e-05 25.5 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE41887.1 - 4.3e-06 26.4 0.1 5.8e-05 22.7 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 EKE41887.1 - 0.00082 19.8 0.0 0.0029 18.0 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EKE41887.1 - 0.0011 19.3 0.0 0.0057 16.9 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EKE41887.1 - 0.0012 19.3 0.0 0.005 17.2 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain FeoB_N PF02421.18 EKE41887.1 - 0.0013 18.3 0.1 0.0052 16.3 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_7 PF12775.7 EKE41887.1 - 0.0043 16.6 0.0 0.0074 15.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region TniB PF05621.11 EKE41887.1 - 0.006 16.0 0.0 0.01 15.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein ATPase_2 PF01637.18 EKE41887.1 - 0.01 15.7 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EKE41887.1 - 0.01 15.5 0.2 0.021 14.6 0.1 1.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EKE41887.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MCM PF00493.23 EKE41887.1 - 0.016 14.3 0.0 0.03 13.4 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain Septin PF00735.18 EKE41887.1 - 0.026 13.8 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 Septin cobW PF02492.19 EKE41887.1 - 0.028 14.0 0.0 1.7 8.2 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EKE41887.1 - 0.028 14.3 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 NACHT domain G-alpha PF00503.20 EKE41887.1 - 0.029 13.5 0.1 9.7 5.2 0.0 2.7 1 1 1 2 2 2 0 G-protein alpha subunit ATP_bind_1 PF03029.17 EKE41887.1 - 0.04 13.7 0.1 6.8 6.4 0.0 2.6 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 EKE41887.1 - 0.049 14.0 0.1 0.1 13.0 0.1 1.8 1 1 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.25 EKE41887.1 - 0.12 12.1 0.0 0.18 11.4 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 EKE41887.1 - 0.14 12.2 0.0 0.22 11.5 0.0 1.5 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain C1_1 PF00130.22 EKE41888.1 - 6.4 6.8 19.1 0.15 12.0 4.6 2.3 1 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-BED PF02892.15 EKE41888.1 - 8.6 6.5 9.3 3.6 7.7 2.6 2.6 2 0 0 2 2 2 0 BED zinc finger PRELI PF04707.14 EKE41889.1 - 5e-11 42.7 0.1 1.2e-10 41.5 0.1 1.6 1 1 1 2 2 2 1 PRELI-like family DUF2294 PF10057.9 EKE41889.1 - 0.12 12.5 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) PfkB PF00294.24 EKE41891.1 - 5.5e-47 160.5 0.6 6.8e-47 160.2 0.6 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF89 PF01937.19 EKE41891.1 - 0.057 12.4 0.1 0.11 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF89 Methyltransf_11 PF08241.12 EKE41891.1 - 0.12 13.0 0.0 0.3 11.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PP2C PF00481.21 EKE41893.1 - 1.5e-52 178.8 0.0 2.5e-52 178.1 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE41893.1 - 0.00088 19.0 0.0 0.0016 18.1 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C Intein_splicing PF14890.6 EKE41893.1 - 0.00088 19.2 0.0 0.12 12.3 0.0 2.5 1 1 1 2 2 2 1 Intein splicing domain Tma16 PF11176.8 EKE41893.1 - 2.9 7.8 7.9 1.5 8.7 0.1 3.0 3 0 0 3 3 3 0 Translation machinery-associated protein 16 Pkinase PF00069.25 EKE41895.1 - 9.5e-68 228.4 0.0 1.2e-67 228.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41895.1 - 1.4e-33 116.3 0.0 1.7e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH_3 PF14593.6 EKE41895.1 - 1.2e-20 73.5 0.0 1e-19 70.5 0.0 2.3 2 0 0 2 2 2 1 PH domain Kdo PF06293.14 EKE41895.1 - 1.2e-05 24.7 0.0 2.1e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EKE41895.1 - 5.1e-05 22.7 0.0 0.0001 21.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EKE41895.1 - 0.00098 18.2 0.1 0.0015 17.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EKE41895.1 - 0.0061 16.5 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EKE41895.1 - 0.085 12.5 0.3 0.29 10.7 0.1 1.8 1 1 2 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EKE41895.1 - 0.13 11.0 0.0 0.22 10.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Brix PF04427.18 EKE41899.1 - 8e-32 110.9 0.0 1.1e-31 110.5 0.0 1.2 1 0 0 1 1 1 1 Brix domain GBP PF02263.19 EKE41900.1 - 5.7e-24 84.8 0.8 9.6e-24 84.0 0.8 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 EKE41900.1 - 0.0096 16.0 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.6 EKE41900.1 - 0.064 13.3 3.0 0.071 13.1 0.1 2.6 2 2 1 3 3 3 0 AAA domain RNA_helicase PF00910.22 EKE41900.1 - 0.26 11.7 2.7 8 6.9 0.0 3.8 4 1 0 4 4 4 0 RNA helicase HD_3 PF13023.6 EKE41901.1 - 1.4e-42 145.4 0.1 1.6e-42 145.2 0.1 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EKE41901.1 - 3.5e-15 56.2 0.1 4.6e-15 55.8 0.1 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EKE41901.1 - 0.00063 20.0 0.1 0.00093 19.4 0.1 1.4 1 1 0 1 1 1 1 HD domain Peptidase_C65 PF10275.9 EKE41902.1 - 0.24 10.8 10.8 2.1 7.7 4.0 2.8 1 1 2 3 3 3 0 Peptidase C65 Otubain LMBR1 PF04791.16 EKE41902.1 - 0.86 8.4 6.7 1 8.2 6.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein EnY2 PF10163.9 EKE41902.1 - 1.6 9.2 9.8 0.48 10.8 1.5 3.1 4 0 0 4 4 4 0 Transcription factor e(y)2 DUF445 PF04286.12 EKE41902.1 - 3.9 7.2 13.9 11 5.6 13.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF445) DUF760 PF05542.11 EKE41902.1 - 6.5 7.2 6.2 45 4.5 5.8 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF760) tRNA-synt_2 PF00152.20 EKE41903.1 - 5.1e-80 268.9 0.9 5.4e-80 268.8 0.1 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EKE41903.1 - 1.6e-06 28.0 0.8 3.1e-06 27.1 0.8 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EKE41903.1 - 6.8e-05 22.5 0.1 0.029 13.9 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) HMW1C_N PF18071.1 EKE41904.1 - 0.044 13.6 0.0 0.052 13.3 0.0 1.0 1 0 0 1 1 1 0 HMW1C N-terminal DUF4366 PF14283.6 EKE41905.1 - 0.0058 16.7 2.6 0.013 15.6 2.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) Prion PF00377.18 EKE41905.1 - 0.012 15.4 0.5 0.012 15.4 0.5 2.6 3 0 0 3 3 3 0 Prion/Doppel alpha-helical domain Glycophorin_A PF01102.18 EKE41905.1 - 0.041 14.1 3.8 0.083 13.1 3.4 1.7 1 1 0 1 1 1 0 Glycophorin A TMEM154 PF15102.6 EKE41905.1 - 0.065 13.1 7.5 0.025 14.5 4.6 1.8 1 1 0 1 1 1 0 TMEM154 protein family EssA PF10661.9 EKE41905.1 - 0.51 10.2 15.7 0.067 13.0 10.7 2.0 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA YjeF_N PF03853.15 EKE41906.1 - 1.8e-40 138.6 0.0 2.4e-40 138.2 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus UEV PF05743.13 EKE41907.1 - 0.012 15.5 0.2 0.027 14.3 0.2 1.6 1 0 0 1 1 1 0 UEV domain PQ-loop PF04193.14 EKE41908.1 - 1.1e-14 53.9 0.9 1.1e-14 53.9 0.9 3.1 4 0 0 4 4 4 2 PQ loop repeat OST3_OST6 PF04756.13 EKE41908.1 - 0.023 14.1 7.9 0.036 13.4 7.9 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family ER_lumen_recept PF00810.18 EKE41908.1 - 0.18 12.6 10.4 0.27 12.0 10.4 1.3 1 0 0 1 1 1 0 ER lumen protein retaining receptor CMS1 PF14617.6 EKE41908.1 - 0.21 10.9 0.1 0.3 10.4 0.1 1.2 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Rft-1 PF04506.13 EKE41909.1 - 1.4e-78 264.9 43.8 2e-78 264.4 43.8 1.1 1 0 0 1 1 1 1 Rft protein Polysacc_synt_3 PF13440.6 EKE41909.1 - 6.4e-05 22.3 13.3 6.4e-05 22.3 13.3 2.7 2 2 1 3 3 3 1 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.6 EKE41909.1 - 0.0014 18.7 11.6 0.0014 18.7 11.6 4.2 3 1 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain DUF4231 PF14015.6 EKE41909.1 - 7.1 7.2 7.5 7.1 7.2 0.4 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF4231) DHR-2 PF06920.13 EKE41910.1 - 1.9e-64 218.2 10.3 1.9e-64 218.2 10.3 4.2 3 1 2 5 5 5 1 Dock homology region 2 DOCK-C2 PF14429.6 EKE41910.1 - 7.3e-27 94.4 3.5 7.3e-27 94.4 3.5 3.0 2 1 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins EF-hand_7 PF13499.6 EKE41910.1 - 0.0062 17.0 0.6 0.0062 17.0 0.6 4.3 6 0 0 6 6 6 1 EF-hand domain pair Rotamase_3 PF13616.6 EKE41910.1 - 0.015 15.9 0.8 0.55 10.8 0.4 3.6 3 0 0 3 3 3 0 PPIC-type PPIASE domain EF-hand_6 PF13405.6 EKE41910.1 - 0.019 14.9 0.3 0.22 11.6 0.1 3.1 2 0 0 2 2 2 0 EF-hand domain Spore_III_AB PF09548.10 EKE41910.1 - 2.2 8.3 7.1 2.7 8.1 3.7 3.0 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) RTX PF02382.15 EKE41910.1 - 8.7 5.9 8.0 0.68 9.6 2.4 2.0 2 0 0 2 2 2 0 N-terminal domain in RTX protein Pkinase_Tyr PF07714.17 EKE41911.1 - 7.5e-46 156.5 0.0 2e-45 155.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41911.1 - 1.3e-39 136.2 0.0 5.3e-39 134.2 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain LRR_8 PF13855.6 EKE41911.1 - 7.1e-13 48.1 30.7 3.1e-07 30.1 1.0 5.1 2 2 1 4 4 4 3 Leucine rich repeat Myotub-related PF06602.14 EKE41911.1 - 1.6e-09 37.2 2.0 4.1e-09 35.8 2.0 1.8 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain LRR_4 PF12799.7 EKE41911.1 - 3.4e-07 30.5 51.6 0.0011 19.3 1.2 7.5 4 2 3 8 8 8 6 Leucine Rich repeats (2 copies) Kdo PF06293.14 EKE41911.1 - 0.012 15.0 0.0 0.028 13.8 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EKE41911.1 - 0.016 15.1 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Radical_SAM PF04055.21 EKE41912.1 - 1.4e-20 74.3 1.9 2.1e-20 73.8 1.9 1.3 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.20 EKE41912.1 - 1.2e-11 44.5 1.1 1.2e-11 44.5 1.1 1.9 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 EKE41912.1 - 0.098 12.7 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 TRAM domain EF-hand_8 PF13833.6 EKE41913.1 - 0.00031 20.5 0.0 0.00031 20.5 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EKE41913.1 - 0.0022 17.4 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EKE41913.1 - 0.062 13.8 0.0 0.062 13.8 0.0 1.1 1 0 0 1 1 1 0 EF-hand domain pair AAA PF00004.29 EKE41914.1 - 3.5e-42 144.0 0.0 6.2e-42 143.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EKE41914.1 - 7.6e-12 44.9 0.1 1.9e-11 43.6 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EKE41914.1 - 1.6e-08 34.3 0.1 3.1e-08 33.5 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EKE41914.1 - 1.2e-07 32.3 0.3 6.4e-05 23.4 0.1 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EKE41914.1 - 3.3e-07 30.4 0.2 9e-06 25.7 0.2 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EKE41914.1 - 4.3e-07 30.2 0.0 2.7e-06 27.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EKE41914.1 - 6.5e-06 26.0 0.0 2.1e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EKE41914.1 - 6.8e-06 26.4 0.7 0.0039 17.5 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.6 EKE41914.1 - 0.00014 22.4 0.0 0.0013 19.3 0.0 2.6 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 EKE41914.1 - 0.00041 20.7 0.0 0.0012 19.2 0.0 1.9 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 EKE41914.1 - 0.001 18.3 0.3 0.0036 16.6 0.0 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain DUF815 PF05673.13 EKE41914.1 - 0.0011 18.2 0.0 0.0021 17.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EKE41914.1 - 0.002 17.9 0.0 0.0039 16.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 EKE41914.1 - 0.0022 17.4 0.1 0.0063 15.9 0.1 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EKE41914.1 - 0.0039 17.5 0.0 0.0067 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EKE41914.1 - 0.0042 17.3 0.0 0.0077 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EKE41914.1 - 0.0048 16.9 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EKE41914.1 - 0.0048 16.4 0.0 0.015 14.8 0.0 1.9 1 1 0 1 1 1 1 P-loop containing dynein motor region TsaE PF02367.17 EKE41914.1 - 0.0082 16.1 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 EKE41914.1 - 0.0099 15.7 0.0 0.022 14.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EKE41914.1 - 0.012 15.3 0.0 0.025 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EKE41914.1 - 0.021 13.9 0.0 0.059 12.5 0.0 1.7 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 EKE41914.1 - 0.029 14.3 0.0 0.096 12.6 0.0 1.8 1 1 1 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 EKE41914.1 - 0.035 13.8 0.1 0.17 11.6 0.0 2.1 1 1 1 2 2 2 0 Sigma-54 interaction domain ATPase PF06745.13 EKE41914.1 - 0.041 13.2 0.8 0.34 10.2 0.0 2.6 3 0 0 3 3 3 0 KaiC ATPase_2 PF01637.18 EKE41914.1 - 0.051 13.5 0.5 0.88 9.4 0.0 2.5 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea Guanylate_kin PF00625.21 EKE41914.1 - 0.06 13.0 0.5 8.1 6.1 0.0 3.0 3 1 1 4 4 3 0 Guanylate kinase Sigma54_activ_2 PF14532.6 EKE41914.1 - 0.06 13.5 0.0 0.17 12.0 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 EKE41914.1 - 0.068 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EKE41914.1 - 0.07 12.6 0.1 0.18 11.2 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.6 EKE41914.1 - 0.079 12.7 0.2 0.19 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF1366 PF07104.11 EKE41914.1 - 0.094 12.4 1.7 0.24 11.1 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1366) Sec8_exocyst PF04048.14 EKE41914.1 - 0.1 12.5 2.0 0.27 11.1 2.0 1.6 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain ABC_tran PF00005.27 EKE41914.1 - 0.12 12.8 0.1 0.51 10.8 0.0 2.1 2 1 1 3 3 2 0 ABC transporter CPBP PF02517.16 EKE41915.1 - 2e-07 31.3 19.4 1e-05 25.8 19.4 2.6 1 1 0 1 1 1 1 CPBP intramembrane metalloprotease Ycf9 PF01737.17 EKE41915.1 - 0.16 11.9 0.2 0.16 11.9 0.2 2.8 2 1 1 3 3 3 0 YCF9 PerB PF06590.11 EKE41915.1 - 0.81 10.2 5.6 0.35 11.4 2.0 2.2 1 1 2 3 3 3 0 PerB protein SNARE PF05739.19 EKE41916.1 - 2.3e-14 53.1 0.6 7.3e-14 51.5 0.6 1.9 1 0 0 1 1 1 1 SNARE domain Tropomyosin_1 PF12718.7 EKE41916.1 - 0.0021 18.3 20.7 0.062 13.5 9.1 2.2 2 0 0 2 2 2 2 Tropomyosin like Fzo_mitofusin PF04799.13 EKE41916.1 - 0.0036 16.9 3.3 0.0036 16.9 3.3 2.3 2 0 0 2 2 2 1 fzo-like conserved region LMBR1 PF04791.16 EKE41916.1 - 0.025 13.5 9.1 0.033 13.1 9.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Orf78 PF06024.12 EKE41916.1 - 0.029 14.7 2.4 0.029 14.7 2.4 2.5 2 1 1 3 3 3 0 Orf78 (ac78) Tweety PF04906.13 EKE41916.1 - 0.067 11.9 10.3 0.16 10.6 2.2 2.0 2 0 0 2 2 2 0 Tweety DUF4191 PF13829.6 EKE41916.1 - 0.12 11.6 2.1 0.14 11.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) DUF4448 PF14610.6 EKE41916.1 - 0.33 10.7 3.1 0.44 10.3 3.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) DUF4199 PF13858.6 EKE41916.1 - 0.34 11.3 5.6 3.6 8.0 0.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) DASH_Dam1 PF08653.10 EKE41916.1 - 0.69 9.8 5.0 2 8.3 0.3 2.8 3 0 0 3 3 3 0 DASH complex subunit Dam1 Mvb12 PF09452.10 EKE41916.1 - 0.73 10.3 8.7 0.23 11.9 1.2 2.8 1 1 2 3 3 3 0 ESCRT-I subunit Mvb12 DUF1664 PF07889.12 EKE41916.1 - 0.93 9.5 12.7 2.9 8.0 1.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2207 PF09972.9 EKE41916.1 - 0.98 8.1 13.5 50 2.5 13.5 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Renin_r PF07850.14 EKE41916.1 - 2.4 8.8 8.6 0.15 12.6 1.8 2.3 2 2 0 2 2 2 0 Renin receptor-like protein DUF3450 PF11932.8 EKE41916.1 - 3 7.1 19.6 0.73 9.1 8.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) ETRAMP PF09716.10 EKE41916.1 - 3.8 7.7 13.4 25 5.0 13.4 2.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Laminin_II PF06009.12 EKE41916.1 - 4.3 7.4 13.1 4 7.4 2.3 2.3 2 1 0 2 2 2 0 Laminin Domain II DUF1899 PF08953.11 EKE41917.1 - 6e-31 106.1 4.7 3.5e-16 58.8 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EKE41917.1 - 4.4e-19 68.1 0.0 6.9e-12 45.1 0.0 2.4 2 0 0 2 2 2 2 Type of WD40 repeat ANAPC4_WD40 PF12894.7 EKE41917.1 - 2.4e-14 53.4 0.4 0.0014 18.8 0.0 4.7 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EKE41917.1 - 1.1e-12 48.3 14.9 0.13 13.2 0.1 8.1 8 0 0 8 8 8 4 WD domain, G-beta repeat Ras PF00071.22 EKE41918.1 - 7.6e-54 181.7 0.1 8.8e-54 181.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41918.1 - 6.7e-31 107.0 0.0 1e-30 106.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41918.1 - 2.2e-12 46.8 0.0 2.8e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE41918.1 - 3.5e-07 30.3 0.1 0.00052 20.0 0.0 2.5 3 0 0 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 EKE41918.1 - 7.1e-07 28.9 0.0 3.7e-06 26.6 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE41918.1 - 1.5e-06 28.3 0.0 2.4e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EKE41918.1 - 4.2e-05 23.3 0.0 0.0018 18.0 0.0 2.3 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EKE41918.1 - 5.9e-05 22.5 0.0 7.3e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EKE41918.1 - 0.0012 19.2 0.1 0.0059 16.9 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EKE41918.1 - 0.021 15.2 0.0 0.03 14.7 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EKE41918.1 - 0.025 14.1 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EKE41918.1 - 0.032 14.4 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EKE41918.1 - 0.038 13.6 0.1 0.32 10.6 0.1 2.1 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.10 EKE41918.1 - 0.045 13.2 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 EKE41918.1 - 0.063 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Septin TniB PF05621.11 EKE41918.1 - 0.072 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.29 EKE41918.1 - 0.082 13.3 0.0 0.61 10.5 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EKE41918.1 - 0.087 12.5 0.0 0.18 11.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EKE41918.1 - 0.099 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.13 EKE41918.1 - 0.15 11.2 0.0 0.92 8.6 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF815) DUF1840 PF08895.11 EKE41918.1 - 0.16 12.3 0.2 0.26 11.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) SLBP_RNA_bind PF15247.6 EKE41919.1 - 3.8e-29 100.6 0.6 8.1e-29 99.6 0.6 1.6 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain Ribosomal_S3Ae PF01015.18 EKE41919.1 - 0.015 14.9 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal S3Ae family TK PF00265.18 EKE41920.1 - 0.0053 16.6 0.4 0.0087 15.9 0.4 1.4 1 0 0 1 1 1 1 Thymidine kinase Pkinase_Tyr PF07714.17 EKE41921.1 - 6.6e-54 182.9 0.1 8.1e-54 182.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41921.1 - 1e-53 182.4 0.1 1.4e-53 181.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE41921.1 - 6.7e-09 35.0 0.1 7.8e-09 34.8 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE41921.1 - 0.00045 19.6 0.0 0.00076 18.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EKE41921.1 - 0.011 15.1 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 EKE41921.1 - 0.14 11.1 0.6 3.1 6.6 0.1 2.2 2 0 0 2 2 2 0 Haspin like kinase domain Myotub-related PF06602.14 EKE41922.1 - 1.4e-105 353.1 0.2 2.6e-105 352.2 0.0 1.5 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain GRAM PF02893.20 EKE41922.1 - 2.2e-06 27.5 0.3 5.4e-06 26.3 0.3 1.6 1 0 0 1 1 1 1 GRAM domain Y_phosphatase3 PF13350.6 EKE41922.1 - 0.01 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family BBL5 PF07289.11 EKE41922.1 - 0.037 13.1 0.1 0.077 12.0 0.1 1.4 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein DSPc PF00782.20 EKE41922.1 - 0.098 12.5 0.0 0.32 10.8 0.0 1.9 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain POR_N PF01855.19 EKE41923.1 - 8.6e-80 267.8 0.0 1.3e-79 267.2 0.0 1.3 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.18 EKE41923.1 - 1.7e-27 96.6 0.1 3e-27 95.8 0.1 1.4 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase EKR PF10371.9 EKE41923.1 - 2.4e-19 68.9 0.1 9.9e-19 66.9 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function PFOR_II PF17147.4 EKE41923.1 - 1.8e-12 47.5 0.0 4.4e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II TPP_enzyme_C PF02775.21 EKE41923.1 - 9.3e-09 35.2 0.1 3e-08 33.6 0.1 1.9 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Fer4_21 PF14697.6 EKE41923.1 - 2.7e-07 30.6 12.0 2.7e-07 30.6 12.0 2.7 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EKE41923.1 - 8.2e-07 29.5 28.7 1.6e-06 28.6 13.9 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 EKE41923.1 - 4.4e-06 26.3 20.6 0.00014 21.5 0.8 2.9 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 EKE41923.1 - 6.2e-06 27.1 10.7 6.2e-06 27.1 10.7 2.3 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_6 PF12837.7 EKE41923.1 - 7.4e-05 22.7 17.5 0.00018 21.5 1.6 2.8 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_10 PF13237.6 EKE41923.1 - 0.00015 21.8 23.6 0.00031 20.8 11.3 2.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EKE41923.1 - 0.00039 20.5 16.7 0.0018 18.4 15.1 2.6 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_8 PF13183.6 EKE41923.1 - 0.00071 20.0 12.6 0.00071 20.0 12.6 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 EKE41923.1 - 0.0092 16.5 15.9 0.041 14.4 14.6 2.6 1 1 2 3 3 3 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EKE41923.1 - 0.023 14.8 20.8 0.027 14.5 4.2 3.0 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_4 PF12800.7 EKE41923.1 - 0.27 11.8 16.5 0.76 10.4 5.4 3.0 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 EKE41923.1 - 0.57 10.4 7.3 2.3 8.5 1.1 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain LRR_5 PF13306.6 EKE41924.1 - 1.5e-95 315.9 52.4 1e-32 112.8 9.3 5.1 1 1 4 5 5 5 5 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE41924.1 - 2.9e-17 62.2 13.5 6.9e-05 22.5 0.0 8.7 5 3 5 11 11 11 8 Leucine rich repeat hDGE_amylase PF14701.6 EKE41925.1 - 3.3e-129 431.8 4.3 3.9e-129 431.6 2.7 2.0 2 1 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EKE41925.1 - 3.7e-102 342.1 0.1 6.4e-102 341.4 0.1 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EKE41925.1 - 2e-25 89.9 0.9 2e-25 89.9 0.9 2.1 2 1 0 2 2 2 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EKE41925.1 - 0.00023 21.2 2.0 0.00066 19.8 2.0 1.8 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Cnd2 PF05786.14 EKE41926.1 - 5.6e-24 84.9 2.2 5.6e-24 84.9 2.2 3.0 2 1 1 3 3 3 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EKE41926.1 - 2.7e-07 30.8 0.4 2.7e-07 30.8 0.4 2.2 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Sec3_C_2 PF15278.6 EKE41926.1 - 0.81 10.1 7.4 1.8 9.0 0.0 4.3 5 0 0 5 5 5 0 Sec3 exocyst complex subunit PTPRCAP PF15713.5 EKE41926.1 - 1.9 8.8 8.9 4 7.7 1.1 2.6 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated CYTH PF01928.21 EKE41927.1 - 1.8e-10 41.0 0.6 2.5e-10 40.6 0.6 1.2 1 0 0 1 1 1 1 CYTH domain CH PF00307.31 EKE41928.1 - 6e-11 42.5 0.0 1.3e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain LIM PF00412.22 EKE41928.1 - 4.3e-06 26.9 7.0 8e-06 26.0 7.0 1.5 1 0 0 1 1 1 1 LIM domain CDC27 PF09507.10 EKE41928.1 - 0.0071 15.8 24.6 0.0071 15.8 24.6 2.1 2 0 0 2 2 2 1 DNA polymerase subunit Cdc27 CAMSAP_CH PF11971.8 EKE41928.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 CAMSAP CH domain zf_C2H2_13 PF18508.1 EKE41928.1 - 0.03 13.9 3.4 2.2 7.9 0.1 2.8 2 1 1 3 3 3 0 Zinc finger domain NOB1_Zn_bind PF08772.11 EKE41928.1 - 1 9.6 8.1 0.68 10.1 2.4 2.5 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like C1_1 PF00130.22 EKE41928.1 - 1.4 8.8 5.5 37 4.3 3.7 2.7 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 EKE41928.1 - 3.7 7.7 9.0 57 3.9 9.0 2.5 1 1 0 1 1 1 0 Double zinc ribbon YPEB PF14620.6 EKE41928.1 - 4.1 6.7 13.8 0.33 10.3 0.2 2.2 2 0 0 2 2 2 0 YpeB sporulation YdjO PF14169.6 EKE41928.1 - 5 6.9 6.9 7.2 6.4 1.9 3.1 2 1 0 2 2 2 0 Cold-inducible protein YdjO DUF4407 PF14362.6 EKE41928.1 - 6.5 6.0 19.1 0.52 9.6 12.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) GPCR_chapero_1 PF11904.8 EKE41929.1 - 7.9e-16 58.4 0.9 7.8e-13 48.5 0.0 2.3 1 1 1 2 2 2 2 GPCR-chaperone Ank_4 PF13637.6 EKE41929.1 - 7.2e-08 32.8 0.0 1.3e-06 28.8 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE41929.1 - 1.3e-06 28.6 0.9 6.4e-05 23.2 0.1 3.1 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKE41929.1 - 2e-06 28.3 0.1 2.3e-05 24.9 0.1 2.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKE41929.1 - 2.6e-05 24.2 0.2 0.0057 17.1 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EKE41929.1 - 0.0012 19.2 0.1 0.12 12.9 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Sel1 PF08238.12 EKE41930.1 - 1.6e-54 181.1 19.5 1.4e-07 31.9 0.0 13.2 14 0 0 14 14 14 9 Sel1 repeat Pkinase PF00069.25 EKE41930.1 - 2.7e-42 145.0 0.8 7.4e-42 143.5 0.1 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41930.1 - 6.1e-30 104.4 0.0 1.3e-29 103.3 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_6 PF13174.6 EKE41930.1 - 5.4e-08 33.0 8.3 11 6.9 0.1 9.5 10 1 0 10 10 10 2 Tetratricopeptide repeat Pkinase_fungal PF17667.1 EKE41930.1 - 2.3e-06 26.7 0.0 4.7e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase TPR_16 PF13432.6 EKE41930.1 - 9.9e-05 22.9 0.2 8.4 7.1 0.0 5.8 3 2 4 7 7 7 1 Tetratricopeptide repeat FTA2 PF13095.6 EKE41930.1 - 0.22 11.1 2.5 3 7.4 0.0 2.8 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 TPR_17 PF13431.6 EKE41930.1 - 0.91 10.0 10.8 23 5.7 0.2 6.1 7 0 0 7 7 7 0 Tetratricopeptide repeat Med14 PF08638.11 EKE41931.1 - 6e-08 32.3 0.6 3.1e-07 30.0 0.1 2.2 2 0 0 2 2 2 1 Mediator complex subunit MED14 DUF2577 PF10844.8 EKE41931.1 - 0.02 15.1 0.3 0.099 12.9 0.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2577) EF-hand_1 PF00036.32 EKE41932.1 - 0.066 12.8 1.4 0.18 11.4 1.4 1.8 1 0 0 1 1 1 0 EF hand Casc1_N PF15927.5 EKE41932.1 - 0.39 10.4 8.8 2.2 7.9 1.2 2.1 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus Intron_maturas2 PF01348.21 EKE41934.1 - 0.0043 17.0 0.7 0.022 14.7 0.5 2.3 2 1 0 2 2 2 1 Type II intron maturase Smr PF01713.21 EKE41935.1 - 1.4e-08 34.9 0.0 2.7e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Smr domain CUE PF02845.16 EKE41935.1 - 0.00025 20.7 2.7 0.0051 16.5 0.2 2.7 2 0 0 2 2 2 2 CUE domain Pkinase PF00069.25 EKE41936.1 - 5.2e-48 163.7 0.7 9.8e-48 162.8 0.7 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41936.1 - 8.5e-48 162.9 0.1 1.4e-47 162.2 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE41936.1 - 2.6e-08 33.1 0.0 4.6e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase VSP PF03302.13 EKE41936.1 - 0.6 8.9 133.0 0.0045 15.9 20.2 5.2 1 1 4 5 5 5 0 Giardia variant-specific surface protein ubiquitin PF00240.23 EKE41937.1 - 2.7e-09 36.6 0.1 3.3e-09 36.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKE41937.1 - 1.5e-05 24.7 0.0 2.1e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TUG-UBL1 PF11470.8 EKE41937.1 - 0.0025 18.0 0.0 0.004 17.4 0.0 1.3 1 0 0 1 1 1 1 TUG ubiquitin-like domain FERM_N PF09379.10 EKE41937.1 - 0.14 12.1 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 FERM N-terminal domain PAP2_3 PF14378.6 EKE41938.1 - 7.8e-13 48.5 0.7 7.8e-13 48.5 0.7 2.9 3 0 0 3 3 3 2 PAP2 superfamily PAP2 PF01569.21 EKE41938.1 - 7.7e-09 35.4 5.0 7.7e-09 35.4 5.0 2.7 2 1 1 3 3 3 1 PAP2 superfamily PAP2_C PF14360.6 EKE41938.1 - 0.00085 19.8 3.9 0.00085 19.8 3.9 4.0 4 1 1 5 5 5 1 PAP2 superfamily C-terminal Pkinase_Tyr PF07714.17 EKE41939.1 - 3.4e-53 180.6 0.1 5.6e-53 179.9 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE41939.1 - 3e-50 171.1 0.1 6e-50 170.0 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE41939.1 - 6.1e-08 31.9 0.1 9.7e-08 31.2 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase DUF3149 PF11346.8 EKE41939.1 - 0.011 15.3 0.5 0.026 14.1 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Kdo PF06293.14 EKE41939.1 - 0.034 13.5 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4301 PF14134.6 EKE41939.1 - 0.049 12.4 0.0 0.074 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4301) Motile_Sperm PF00635.26 EKE41939.1 - 0.073 12.9 0.9 0.13 12.1 0.2 1.8 2 0 0 2 2 2 0 MSP (Major sperm protein) domain VSP PF03302.13 EKE41939.1 - 4.4 6.1 150.2 81 1.9 83.4 6.4 1 1 1 2 2 2 0 Giardia variant-specific surface protein Insulin_TMD PF17870.1 EKE41939.1 - 9.1 6.4 8.3 1.2 9.3 3.2 2.1 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment CytochromB561_N PF09786.9 EKE41940.1 - 0.05 12.6 0.5 0.057 12.4 0.5 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal IU_nuc_hydro PF01156.19 EKE41941.1 - 7e-47 160.5 0.3 4.5e-37 128.3 0.0 2.0 1 1 1 2 2 2 2 Inosine-uridine preferring nucleoside hydrolase MOZART2 PF12926.7 EKE41942.1 - 0.044 13.4 0.0 0.26 10.9 0.0 2.3 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated VanZ PF04892.12 EKE41942.1 - 0.11 13.2 3.0 0.55 10.9 0.0 3.3 2 1 1 3 3 3 0 VanZ like family Clathrin-link PF09268.10 EKE41942.1 - 0.15 11.4 0.5 0.54 9.7 0.5 1.9 1 0 0 1 1 1 0 Clathrin, heavy-chain linker Arm_vescicular PF18770.1 EKE41942.1 - 1.1 9.2 7.1 12 6.0 0.0 4.9 4 1 1 5 5 5 0 Armadillo tether-repeat of vescicular transport factor HEAT PF02985.22 EKE41943.1 - 2.5e-21 73.9 9.0 0.00065 19.8 0.0 11.8 10 0 0 10 10 10 3 HEAT repeat HEAT_EZ PF13513.6 EKE41943.1 - 1.3e-20 73.5 5.7 2.6e-06 27.8 0.0 9.2 8 1 1 9 9 8 3 HEAT-like repeat HEAT_2 PF13646.6 EKE41943.1 - 4.1e-16 59.2 0.9 0.00082 19.7 0.0 6.8 7 1 0 7 7 7 3 HEAT repeats Vac14_Fab1_bd PF12755.7 EKE41943.1 - 2.8e-10 40.6 0.6 0.0053 17.3 0.0 7.0 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EKE41943.1 - 5.4e-10 39.2 2.3 0.0015 18.2 0.1 6.4 4 2 1 5 5 5 2 CLASP N terminal Cnd1 PF12717.7 EKE41943.1 - 1.2e-08 35.1 35.7 0.012 15.6 0.0 10.5 8 5 3 13 13 12 4 non-SMC mitotic condensation complex subunit 1 DUF3535 PF12054.8 EKE41943.1 - 2.2e-05 23.9 0.2 0.41 9.8 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF3535) Arm PF00514.23 EKE41943.1 - 0.00075 19.5 4.2 1.3 9.2 0.1 5.9 6 0 0 6 6 5 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EKE41943.1 - 0.013 15.6 11.3 12 6.1 0.0 7.0 7 1 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 TFCD_C PF12612.8 EKE41943.1 - 0.013 15.3 1.5 0.61 9.9 0.1 4.1 3 0 0 3 3 3 0 Tubulin folding cofactor D C terminal Cohesin_HEAT PF12765.7 EKE41943.1 - 0.02 15.2 0.1 9.2 6.7 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Blo-t-5 PF11642.8 EKE41943.1 - 0.045 13.7 0.3 0.18 11.8 0.3 2.1 1 0 0 1 1 1 0 Mite allergen Blo t 5 Bac_RepA_C PF18008.1 EKE41943.1 - 3.2 8.2 8.2 6.7 7.1 0.0 5.2 4 1 1 5 5 3 0 Replication initiator protein A C-terminal domain Sda PF08970.10 EKE41943.1 - 8.2 6.3 7.6 0.35 10.7 0.1 2.6 3 0 0 3 3 3 0 Sporulation inhibitor A Vps26 PF03643.15 EKE41944.1 - 0.0006 18.9 0.0 0.00084 18.4 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 CagX PF03524.15 EKE41944.1 - 0.076 12.7 0.2 0.088 12.5 0.2 1.1 1 0 0 1 1 1 0 Conjugal transfer protein WD40 PF00400.32 EKE41945.1 - 4.7e-07 30.4 5.1 0.042 14.7 0.1 5.3 6 0 0 6 6 6 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 EKE41945.1 - 7.5e-05 22.7 0.2 0.027 14.5 0.0 3.1 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region HEAT_2 PF13646.6 EKE41945.1 - 0.063 13.7 0.0 0.29 11.5 0.0 2.0 1 1 1 2 2 2 0 HEAT repeats HEAT PF02985.22 EKE41945.1 - 0.074 13.3 0.0 30 5.2 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat PK PF00224.21 EKE41946.1 - 1.8e-11 43.6 0.2 2e-11 43.4 0.2 1.0 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain UBA_e1_thiolCys PF10585.9 EKE41947.1 - 1.8e-67 227.9 3.7 3.7e-67 226.9 3.7 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site ThiF PF00899.21 EKE41947.1 - 2.1e-66 223.7 0.0 3.1e-54 183.9 0.0 2.5 2 1 0 2 2 2 2 ThiF family E1_FCCH PF16190.5 EKE41947.1 - 3.9e-12 46.2 1.5 9.1e-12 45.0 0.3 2.2 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EKE41947.1 - 5.4e-11 42.5 0.1 1.9e-10 40.8 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle DUF4111 PF13427.6 EKE41947.1 - 0.13 12.5 0.1 34 4.7 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4111) Spatacsin_C PF14649.6 EKE41948.1 - 3.6e-15 55.9 0.8 3.6e-15 55.9 0.8 2.5 3 0 0 3 3 3 1 Spatacsin C-terminus DNA_pol3_gamma3 PF12169.8 EKE41948.1 - 0.015 15.2 1.3 1.5 8.7 0.0 3.2 2 0 0 2 2 2 0 DNA polymerase III subunits gamma and tau domain III DUF3283 PF11686.8 EKE41949.1 - 0.073 12.9 0.0 0.18 11.7 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3283) PepSY_TM PF03929.16 EKE41950.1 - 0.11 12.1 0.4 0.13 11.9 0.4 1.1 1 0 0 1 1 1 0 PepSY-associated TM region DNA_ligase_A_M PF01068.21 EKE41951.1 - 9.5e-60 201.7 0.5 2e-59 200.7 0.5 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EKE41951.1 - 1e-29 104.1 0.2 2.9e-29 102.6 0.0 1.9 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EKE41951.1 - 9.4e-26 90.3 0.0 5.8e-25 87.8 0.0 2.4 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EKE41951.1 - 0.00025 21.4 0.7 0.00056 20.3 0.7 1.6 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 EKE41951.1 - 0.0087 15.9 0.3 0.23 11.2 0.0 2.5 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain DNA_ligase_OB_2 PF14743.6 EKE41951.1 - 0.02 14.9 0.5 0.41 10.7 0.1 2.7 2 0 0 2 2 2 0 DNA ligase OB-like domain DUF4325 PF14213.6 EKE41951.1 - 0.053 13.2 0.0 0.2 11.4 0.0 2.0 1 0 0 1 1 1 0 STAS-like domain of unknown function (DUF4325) Actin PF00022.19 EKE41952.1 - 2.5e-105 352.4 0.0 2.3e-104 349.2 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EKE41952.1 - 0.00021 20.2 0.0 0.24 10.2 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein TMEM234 PF10639.9 EKE41953.1 - 5e-33 113.6 5.7 5e-33 113.6 5.7 1.4 2 0 0 2 2 2 1 Putative transmembrane family 234 EamA PF00892.20 EKE41953.1 - 0.04 14.1 15.1 0.27 11.4 8.5 2.7 1 1 2 3 3 3 0 EamA-like transporter family TssN PF17555.2 EKE41953.1 - 1.2 8.5 12.9 1.4 8.2 12.9 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN Pkinase PF00069.25 EKE41954.1 - 3.6e-15 56.0 0.6 1.1e-07 31.4 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41954.1 - 1e-05 25.0 0.0 3.3e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EKE41954.1 - 2.5e-05 24.7 0.5 5e-05 23.8 0.5 1.5 1 0 0 1 1 1 1 PH domain PI3K_P85_iSH2 PF16454.5 EKE41954.1 - 0.033 13.8 2.8 0.061 12.9 2.8 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Tropomyosin_1 PF12718.7 EKE41954.1 - 0.082 13.1 1.4 0.28 11.3 1.6 1.8 2 0 0 2 2 2 0 Tropomyosin like DUF5595 PF18077.1 EKE41954.1 - 0.17 12.0 5.9 0.046 13.8 1.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) DUF2730 PF10805.8 EKE41954.1 - 0.29 11.3 5.9 0.12 12.5 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) KIAA1430 PF13879.6 EKE41954.1 - 0.3 11.9 2.8 0.57 11.0 2.8 1.5 1 0 0 1 1 1 0 KIAA1430 homologue SlyX PF04102.12 EKE41954.1 - 0.61 10.7 2.0 1.2 9.8 2.0 1.5 1 0 0 1 1 1 0 SlyX RRP7 PF12923.7 EKE41955.1 - 1.7e-12 47.5 12.9 2e-12 47.3 12.9 1.1 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Y_phosphatase3 PF13350.6 EKE41956.1 - 7.8e-07 29.3 0.0 1.3e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EKE41956.1 - 1.6e-05 24.7 0.4 4.3e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EKE41956.1 - 7.3e-05 22.4 0.5 0.00013 21.6 0.0 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTEN_C2 PF10409.9 EKE41956.1 - 0.00014 21.6 0.1 0.00028 20.6 0.1 1.6 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein CDKN3 PF05706.12 EKE41956.1 - 0.025 14.3 0.0 0.07 12.8 0.0 1.8 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 EKE41956.1 - 0.029 14.5 0.3 0.064 13.4 0.0 1.7 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 EKE41956.1 - 0.061 12.9 1.4 0.077 12.6 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family UBX PF00789.20 EKE41957.1 - 4.5e-09 36.4 0.0 1.2e-08 35.1 0.0 1.7 1 0 0 1 1 1 1 UBX domain PIF1 PF05970.14 EKE41958.1 - 6.6e-56 190.0 6.6 9.3e-45 153.4 0.3 3.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EKE41958.1 - 5.6e-21 75.1 0.0 9e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKE41958.1 - 8.1e-10 39.2 0.0 3.8e-09 37.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain Herpes_Helicase PF02689.14 EKE41958.1 - 1.1e-08 33.6 0.3 0.00068 17.7 0.1 2.4 2 0 0 2 2 2 2 Helicase AAA_22 PF13401.6 EKE41958.1 - 1.4e-06 28.6 0.0 3.7e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EKE41958.1 - 4.6e-05 23.8 0.1 0.00011 22.7 0.1 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EKE41958.1 - 0.00016 21.5 0.4 0.017 14.9 0.3 3.7 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 EKE41958.1 - 0.0013 18.8 0.1 0.015 15.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EKE41958.1 - 0.0024 17.9 0.1 0.018 15.1 0.1 2.6 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EKE41958.1 - 0.0028 17.5 0.1 0.011 15.6 0.1 2.0 1 1 0 1 1 1 1 Helicase ATPase_2 PF01637.18 EKE41958.1 - 0.0032 17.4 0.6 0.029 14.3 0.6 2.5 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea DUF2075 PF09848.9 EKE41958.1 - 0.0048 16.2 0.1 0.016 14.5 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EKE41958.1 - 0.0099 15.0 0.1 0.027 13.5 0.1 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 EKE41958.1 - 0.015 14.8 0.2 0.19 11.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 EKE41958.1 - 0.022 15.1 0.1 0.046 14.1 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain Membr_traf_MHD PF10540.9 EKE41958.1 - 0.096 12.9 0.3 0.26 11.4 0.3 1.7 1 0 0 1 1 1 0 Munc13 (mammalian uncoordinated) homology domain AAA_17 PF13207.6 EKE41958.1 - 0.097 13.1 0.1 0.32 11.4 0.1 1.9 1 0 0 1 1 1 0 AAA domain UvrD_C_2 PF13538.6 EKE41958.1 - 0.11 12.3 0.0 0.32 10.9 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain ATP-synt_ab PF00006.25 EKE41958.1 - 0.13 11.8 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain RsgA_GTPase PF03193.16 EKE41958.1 - 0.2 11.6 1.3 0.37 10.7 0.1 2.0 2 0 0 2 2 2 0 RsgA GTPase Sec62 PF03839.16 EKE41959.1 - 8.6 5.8 8.9 16 4.9 8.9 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Mpp10 PF04006.12 EKE41960.1 - 7.4e-57 193.2 45.4 3.3e-52 177.8 34.5 2.0 1 1 1 2 2 2 2 Mpp10 protein DUF5357 PF17310.2 EKE41960.1 - 1.4 7.4 3.7 8.9 4.8 0.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5357) ALMT PF11744.8 EKE41960.1 - 1.6 7.5 7.6 3 6.6 7.6 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter RhoGEF PF00621.20 EKE41961.1 - 8.7e-33 114.1 13.5 8.7e-33 114.1 13.5 3.6 3 1 1 4 4 4 1 RhoGEF domain Vac14_Fab1_bd PF12755.7 EKE41961.1 - 0.39 11.3 4.3 14 6.3 0.2 3.5 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region FeS_assembly_P PF01883.19 EKE41963.1 - 2.4e-07 30.8 0.0 6.7e-07 29.4 0.0 1.7 1 1 1 2 2 2 1 Iron-sulfur cluster assembly protein Glyco_hydro_1 PF00232.18 EKE41963.1 - 0.21 9.9 0.1 0.2 10.1 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 PH_11 PF15413.6 EKE41964.1 - 0.46 10.9 3.2 18 5.8 0.1 3.4 2 2 0 2 2 2 0 Pleckstrin homology domain RhoGAP PF00620.27 EKE41965.1 - 1.8e-22 79.8 1.3 3.2e-22 79.0 0.3 1.9 2 0 0 2 2 2 1 RhoGAP domain SLATT_6 PF18169.1 EKE41965.1 - 0.0033 17.0 1.3 0.0081 15.8 0.9 1.8 1 1 1 2 2 2 1 SMODS and SLOG-associating 2TM effector domain 6 Seryl_tRNA_N PF02403.22 EKE41965.1 - 0.012 15.8 3.1 1.3 9.3 0.4 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Orf78 PF06024.12 EKE41966.1 - 0.024 14.9 0.8 0.024 14.9 0.8 2.0 2 0 0 2 2 2 0 Orf78 (ac78) DUF997 PF06196.12 EKE41966.1 - 0.025 14.6 1.1 0.033 14.2 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF997) Insulin_TMD PF17870.1 EKE41966.1 - 0.029 14.5 2.8 0.053 13.6 2.8 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF1700 PF08006.11 EKE41966.1 - 0.043 13.4 1.0 0.066 12.7 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF5345 PF17280.2 EKE41966.1 - 0.33 11.0 1.9 1 9.4 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Shisa PF13908.6 EKE41966.1 - 4.1 7.6 10.3 0.13 12.5 2.6 1.9 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator MPDZ_u10 PF16667.5 EKE41966.1 - 9.1 7.3 22.9 3.2 8.7 1.5 3.3 1 1 2 3 3 3 0 Unstructured region 10 on multiple PDZ protein FH2 PF02181.23 EKE41967.1 - 4.8e-80 269.4 5.9 4.8e-80 269.4 5.9 3.6 4 0 0 4 4 4 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 EKE41967.1 - 1.4e-09 37.9 5.8 5e-09 36.1 5.8 1.9 1 0 0 1 1 1 1 Diaphanous FH3 Domain Drf_FH1 PF06346.12 EKE41967.1 - 1.6e-05 24.7 45.6 2.9e-05 23.9 45.6 1.3 1 0 0 1 1 1 1 Formin Homology Region 1 Drf_GBD PF06371.13 EKE41967.1 - 5e-05 22.9 2.8 5e-05 22.9 2.8 2.9 4 0 0 4 4 4 1 Diaphanous GTPase-binding Domain Mito_fiss_reg PF05308.11 EKE41967.1 - 5.3e-05 23.4 9.0 0.00012 22.2 4.5 2.7 2 0 0 2 2 2 1 Mitochondrial fission regulator C1_1 PF00130.22 EKE41967.1 - 0.00025 20.8 2.3 0.00057 19.7 2.3 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 EKE41967.1 - 0.00093 19.1 4.6 0.0021 17.9 4.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 DNA_RNApol_7kD PF03604.13 EKE41967.1 - 0.029 14.1 2.7 0.074 12.7 2.7 1.6 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Phage_RpbA PF10789.9 EKE41967.1 - 0.04 14.0 0.2 0.04 14.0 0.2 2.5 2 0 0 2 2 2 0 Phage RNA polymerase binding, RpbA zf-RING_2 PF13639.6 EKE41967.1 - 0.64 10.4 4.7 1.7 9.0 4.7 1.8 1 0 0 1 1 1 0 Ring finger domain PHD PF00628.29 EKE41967.1 - 3.9 7.4 6.7 9.4 6.2 6.7 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING_9 PF13901.6 EKE41967.1 - 6.6 6.7 10.6 2.2 8.2 5.2 2.9 2 1 1 3 3 3 0 Putative zinc-RING and/or ribbon PP2C PF00481.21 EKE41968.1 - 6.6e-50 170.1 0.1 7.3e-50 170.0 0.1 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C RRM_1 PF00076.22 EKE41969.1 - 2.3e-25 88.2 1.0 8.2e-12 44.8 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Acetyltransf_11 PF13720.6 EKE41969.1 - 0.035 14.5 0.3 0.035 14.5 0.3 3.4 3 2 1 4 4 4 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 VASt PF16016.5 EKE41970.1 - 5.6e-14 52.8 1.4 5.6e-14 52.8 1.4 1.8 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EKE41970.1 - 3.7e-07 30.0 1.0 1.1e-06 28.5 0.3 2.1 1 1 1 2 2 2 1 GRAM domain DUF4752 PF15944.5 EKE41970.1 - 0.016 15.2 0.4 0.11 12.6 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4752) DUF3930 PF13067.6 EKE41970.1 - 0.039 14.2 0.5 5.7 7.3 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3930) DUF1948 PF09185.10 EKE41970.1 - 4.3 7.2 7.9 13 5.7 0.2 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF1948) DUF3899 PF13038.6 EKE41970.1 - 6.1 7.4 7.1 2.3 8.8 1.7 2.9 2 2 0 2 2 2 0 Domain of unknown function (DUF3899) ADH_zinc_N PF00107.26 EKE41971.1 - 3.9e-18 65.7 0.4 5.9e-18 65.1 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EKE41971.1 - 5.8e-14 51.9 0.5 4.1e-13 49.2 0.0 2.4 3 1 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EKE41971.1 - 2.2e-06 28.7 0.0 4e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EKE41971.1 - 0.067 12.7 0.2 0.15 11.5 0.2 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus FAE1_CUT1_RppA PF08392.12 EKE41972.1 - 3.7e-104 348.1 0.0 4.8e-104 347.7 0.0 1.1 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III_C PF08541.10 EKE41972.1 - 2.6e-10 40.3 0.0 6e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Chal_sti_synt_C PF02797.15 EKE41972.1 - 8.4e-09 35.6 0.0 2.4e-08 34.1 0.0 1.9 2 0 0 2 2 2 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EKE41972.1 - 0.014 14.9 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Chalcone and stilbene synthases, N-terminal domain DUF4013 PF13197.6 EKE41972.1 - 0.02 14.8 0.4 0.035 14.0 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4013) ACP_syn_III PF08545.10 EKE41972.1 - 0.15 11.9 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III FixS PF03597.15 EKE41972.1 - 0.45 10.3 3.3 0.85 9.4 0.5 2.6 3 0 0 3 3 3 0 Cytochrome oxidase maturation protein cbb3-type Cpn60_TCP1 PF00118.24 EKE41973.1 - 2.8e-161 537.5 8.2 3.2e-161 537.3 8.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SNAP PF14938.6 EKE41974.1 - 4.5e-61 206.8 21.3 5.1e-61 206.6 21.3 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 EKE41974.1 - 3.2e-05 24.3 4.2 2.7 8.8 0.2 4.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EKE41974.1 - 5.7e-05 23.3 9.2 0.014 15.7 1.7 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EKE41974.1 - 0.00027 20.6 12.9 0.012 15.4 1.3 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat DHR-2 PF06920.13 EKE41974.1 - 0.0027 16.4 6.9 0.039 12.6 3.2 2.8 2 2 0 2 2 2 1 Dock homology region 2 TPR_MalT PF17874.1 EKE41974.1 - 0.0031 17.0 0.7 0.5 9.7 0.1 3.0 1 1 2 3 3 3 1 MalT-like TPR region TPR_8 PF13181.6 EKE41974.1 - 0.0037 17.3 15.2 0.088 13.1 1.6 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat Nic96 PF04097.14 EKE41974.1 - 0.0056 15.2 1.0 0.0056 15.2 1.0 1.5 2 0 0 2 2 2 1 Nup93/Nic96 SPOB_a PF14689.6 EKE41974.1 - 0.0058 16.3 1.6 0.12 12.1 0.1 3.2 2 1 1 3 3 3 1 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_16 PF13432.6 EKE41974.1 - 0.0091 16.6 7.8 0.069 13.8 2.3 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EKE41974.1 - 0.019 15.8 3.5 4.1 8.5 0.7 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat Ribosomal_S3Ae PF01015.18 EKE41974.1 - 0.033 13.8 0.2 0.064 12.8 0.2 1.4 1 0 0 1 1 1 0 Ribosomal S3Ae family TPR_7 PF13176.6 EKE41974.1 - 0.04 14.0 3.4 5.7 7.2 0.1 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE41974.1 - 0.052 13.8 5.1 0.23 11.7 1.4 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 YlbD_coat PF14071.6 EKE41974.1 - 0.056 13.7 3.7 0.27 11.5 0.8 2.6 1 1 1 2 2 2 0 Putative coat protein Foie-gras_1 PF11817.8 EKE41974.1 - 0.067 12.8 2.6 0.14 11.7 2.6 1.5 1 0 0 1 1 1 0 Foie gras liver health family 1 TPR_2 PF07719.17 EKE41974.1 - 0.14 12.3 17.9 0.45 10.8 1.0 4.1 5 1 1 6 6 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EKE41974.1 - 0.51 10.1 7.8 6.2 6.6 1.1 3.0 2 0 0 2 2 2 0 TPR repeat Mad3_BUB1_I PF08311.12 EKE41974.1 - 0.66 10.0 6.5 2.5 8.1 0.3 2.4 2 0 0 2 2 2 0 Mad3/BUB1 homology region 1 RPN7 PF10602.9 EKE41974.1 - 0.78 9.4 9.8 0.38 10.4 0.5 2.7 3 0 0 3 3 3 0 26S proteasome subunit RPN7 Spore_YpjB PF09577.10 EKE41974.1 - 0.84 9.4 7.5 0.34 10.7 0.5 2.5 3 0 0 3 3 2 0 Sporulation protein YpjB (SpoYpjB) NSF PF02071.20 EKE41974.1 - 1.8 9.7 12.3 26 6.2 0.2 5.2 4 1 1 5 5 3 0 Aromatic-di-Alanine (AdAR) repeat DUF4363 PF14276.6 EKE41974.1 - 5.6 7.1 8.4 10 6.3 0.3 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4363) DUF2225 PF09986.9 EKE41974.1 - 9.8 5.8 10.3 7.5 6.2 1.2 2.5 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DNA_pol_B_2 PF03175.13 EKE41976.1 - 2.6e-13 49.7 5.2 2.6e-13 49.7 5.2 2.6 2 1 0 2 2 2 1 DNA polymerase type B, organellar and viral DapH_N PF08503.10 EKE41976.1 - 0.067 13.4 1.0 0.25 11.6 0.1 2.4 2 0 0 2 2 2 0 Tetrahydrodipicolinate succinyltransferase N-terminal Peptidase_C1 PF00112.23 EKE41977.1 - 3.4e-29 102.5 7.5 3.4e-29 102.5 7.5 1.6 1 1 1 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE41977.1 - 7.7e-12 45.5 2.2 7.7e-12 45.5 2.2 2.6 3 0 0 3 3 3 1 Cathepsin propeptide inhibitor domain (I29) Pkinase PF00069.25 EKE41978.1 - 6.5e-59 199.4 6.0 2e-58 197.9 2.3 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE41978.1 - 5.7e-28 97.9 0.1 1.8e-27 96.3 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EKE41978.1 - 2.1e-06 27.3 0.4 2.5e-05 23.7 0.1 2.1 1 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EKE41978.1 - 3.9e-05 23.3 0.4 8.9e-05 22.2 0.4 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EKE41978.1 - 0.00014 21.9 0.0 0.00025 21.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EKE41978.1 - 0.00025 20.0 0.1 0.00033 19.5 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKE41978.1 - 0.00069 19.0 0.0 0.0019 17.6 0.0 1.6 1 1 0 1 1 1 1 Kinase-like UPF0183 PF03676.14 EKE41979.1 - 6.8e-07 28.9 1.7 1.4e-06 27.9 1.3 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0183) WD40 PF00400.32 EKE41980.1 - 0.00013 22.7 1.2 0.084 13.8 0.0 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat WD40_like PF17005.5 EKE41980.1 - 0.0051 16.2 0.5 0.017 14.5 0.6 1.6 1 1 0 1 1 1 1 WD40-like domain BBS2_Mid PF14783.6 EKE41980.1 - 0.018 15.1 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 EKE41980.1 - 0.02 13.2 0.0 0.25 9.6 0.0 1.9 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz TLD PF07534.16 EKE41982.1 - 3.1e-07 30.7 5.8 8.4e-07 29.3 5.8 1.7 1 0 0 1 1 1 1 TLD MukF_M PF17192.4 EKE41982.1 - 1.9 8.2 9.8 13 5.5 6.5 2.4 2 1 0 2 2 2 0 MukF middle domain DUF4781 PF16013.5 EKE41982.1 - 3.8 6.2 9.8 5.2 5.8 5.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) LRR_5 PF13306.6 EKE41983.1 - 1.5e-08 34.6 86.5 0.03 14.3 8.5 10.6 2 2 8 11 11 11 9 BspA type Leucine rich repeat region (6 copies) NeuB PF03102.14 EKE41983.1 - 0.1 12.0 2.4 4.7 6.6 0.3 2.8 3 0 0 3 3 3 0 NeuB family DUF5432 PF17497.2 EKE41983.1 - 0.89 9.7 9.6 19 5.4 0.4 5.0 5 0 0 5 5 5 0 Family of unknown function (DUF5432) ADK PF00406.22 EKE41984.1 - 2.6e-42 144.5 0.1 3e-42 144.3 0.1 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EKE41984.1 - 3.7e-26 92.2 0.1 5.3e-26 91.7 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EKE41984.1 - 1.9e-09 38.1 0.1 3.7e-09 37.2 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EKE41984.1 - 3.9e-05 23.8 0.0 5.3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EKE41984.1 - 0.00083 19.1 0.1 0.14 11.8 0.0 2.1 1 1 1 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.12 EKE41984.1 - 0.0034 16.7 0.0 0.0046 16.3 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin NTPase_1 PF03266.15 EKE41984.1 - 0.05 13.5 0.7 0.098 12.6 0.2 1.7 2 1 0 2 2 2 0 NTPase Glyco_hydro_3_C PF01915.22 EKE41984.1 - 0.13 12.2 0.1 0.16 11.9 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain DUF1103 PF06513.11 EKE41984.1 - 0.15 11.6 4.5 0.43 10.2 3.4 2.0 1 1 0 1 1 1 0 Repeat of unknown function (DUF1103) UEV PF05743.13 EKE41985.1 - 2e-16 59.9 0.3 1e-15 57.6 0.0 2.3 3 0 0 3 3 3 1 UEV domain Vps23_core PF09454.10 EKE41985.1 - 0.077 13.0 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Vps23 core domain Ras PF00071.22 EKE41986.1 - 4e-53 179.3 0.1 4.7e-53 179.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE41986.1 - 4.2e-25 88.3 0.0 6.7e-25 87.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE41986.1 - 1.7e-09 37.4 0.1 2.5e-09 36.8 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE41986.1 - 0.0028 17.2 0.1 0.012 15.1 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE41986.1 - 0.003 17.0 0.1 0.0037 16.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ldh_1_N PF00056.23 EKE41986.1 - 0.036 14.2 0.0 3.2 7.8 0.0 2.4 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain MMR_HSR1 PF01926.23 EKE41986.1 - 0.043 13.9 0.0 0.067 13.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 EKE41986.1 - 0.053 13.0 0.7 0.091 12.2 0.0 1.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit RNase_P_Rpp14 PF01900.19 EKE41987.1 - 5.2e-14 52.3 0.0 6.1e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family CAP_N PF01213.19 EKE41988.1 - 2.9e-80 270.1 2.4 4.5e-80 269.5 2.4 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EKE41988.1 - 4.8e-47 159.5 9.6 7.3e-47 158.9 9.6 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EKE41988.1 - 0.0018 18.0 6.6 0.0035 17.1 6.6 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C PIP49_N PF14875.6 EKE41988.1 - 1.3 8.9 6.0 2.1 8.2 0.0 3.0 2 1 1 3 3 3 0 N-term cysteine-rich ER, FAM69 MgtE PF01769.16 EKE41990.1 - 0.03 14.7 17.3 0.84 10.0 0.8 2.7 2 1 0 2 2 2 0 Divalent cation transporter MCLC PF05934.11 EKE41991.1 - 0.0039 16.0 0.1 0.0068 15.2 0.1 1.4 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) DUF4602 PF15375.6 EKE41991.1 - 1.9 8.8 11.5 8 6.8 3.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4602) HSP70 PF00012.20 EKE41992.1 - 6.5e-41 140.2 7.1 6.5e-41 140.2 7.1 2.0 2 0 0 2 2 2 2 Hsp70 protein BcrAD_BadFG PF01869.20 EKE41992.1 - 0.00056 19.5 0.0 0.024 14.1 0.0 2.4 1 1 1 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family Picorna_P3A PF06363.11 EKE41992.1 - 0.012 15.4 0.0 6.1 6.8 0.0 2.7 2 0 0 2 2 2 0 Picornaviridae P3A protein MreB_Mbl PF06723.13 EKE41992.1 - 0.015 14.1 0.0 0.015 14.1 0.0 1.8 2 1 0 2 2 2 0 MreB/Mbl protein FtsA PF14450.6 EKE41992.1 - 2.1 8.8 4.0 1 9.8 1.7 2.0 1 1 0 1 1 1 0 Cell division protein FtsA HSP70 PF00012.20 EKE41993.1 - 1.3e-10 40.1 0.0 1.6e-10 39.9 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF5325 PF17259.2 EKE41993.1 - 0.019 14.8 0.8 0.03 14.2 0.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5325) Ribosomal_S27e PF01667.17 EKE41994.1 - 5.2e-28 96.5 4.6 5.9e-28 96.3 4.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 EKE41994.1 - 2.3e-06 27.0 0.2 3.1e-06 26.6 0.2 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 EKE41994.1 - 0.0004 20.2 0.4 0.00059 19.7 0.4 1.3 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 EKE41994.1 - 0.00044 19.5 5.7 0.02 14.3 5.7 2.3 1 1 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EKE41994.1 - 0.0018 17.9 3.5 0.4 10.4 0.5 2.3 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 EKE41994.1 - 0.002 18.1 4.0 0.024 14.7 5.0 1.9 1 1 1 2 2 2 2 Double zinc ribbon Zn-ribbon_8 PF09723.10 EKE41994.1 - 0.0049 17.0 3.5 0.015 15.4 3.5 1.8 1 1 0 1 1 1 1 Zinc ribbon domain HypA PF01155.19 EKE41994.1 - 0.0087 16.1 1.5 0.01 15.8 1.5 1.2 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1595 PF12760.7 EKE41994.1 - 0.012 15.6 2.2 0.018 15.0 2.2 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 EKE41994.1 - 0.013 15.4 0.2 0.022 14.7 0.2 1.4 1 0 0 1 1 1 0 PhnA Zinc-Ribbon A2L_zn_ribbon PF08792.10 EKE41994.1 - 0.014 15.1 1.8 2.1 8.2 0.1 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain Nop10p PF04135.12 EKE41994.1 - 0.029 14.4 1.5 0.4 10.7 0.1 2.2 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family zf-ACC PF17848.1 EKE41994.1 - 0.031 14.3 5.0 0.16 12.1 0.6 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain DUF2318 PF10080.9 EKE41994.1 - 0.035 14.2 1.0 0.041 14.0 1.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) zf-FPG_IleRS PF06827.14 EKE41994.1 - 0.044 13.7 2.8 0.93 9.4 3.4 2.2 1 1 1 2 2 2 0 Zinc finger found in FPG and IleRS Mu-like_Com PF10122.9 EKE41994.1 - 0.045 13.2 0.3 0.045 13.2 0.3 2.1 1 1 1 2 2 2 0 Mu-like prophage protein Com zf-RRN7 PF11781.8 EKE41994.1 - 0.045 13.4 1.3 2.1 8.1 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 ADK_lid PF05191.14 EKE41994.1 - 0.055 13.5 3.1 0.28 11.2 3.1 2.0 1 1 0 1 1 1 0 Adenylate kinase, active site lid zf-Mss51 PF13824.6 EKE41994.1 - 0.057 13.5 3.7 0.86 9.8 4.2 2.0 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-NADH-PPase PF09297.11 EKE41994.1 - 0.057 13.1 3.7 0.22 11.2 3.7 2.0 1 1 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain HECT_2 PF09814.9 EKE41994.1 - 0.06 12.2 0.3 0.066 12.1 0.3 1.1 1 0 0 1 1 1 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding zinc-ribbons_6 PF07191.12 EKE41994.1 - 0.06 13.3 3.7 0.1 12.6 3.7 1.5 1 1 0 1 1 1 0 zinc-ribbons Lar_restr_allev PF14354.6 EKE41994.1 - 0.066 13.6 2.4 0.11 12.9 2.4 1.5 1 1 0 1 1 1 0 Restriction alleviation protein Lar DUF2614 PF11023.8 EKE41994.1 - 0.074 13.1 0.2 0.082 13.0 0.2 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain DUF2752 PF10825.8 EKE41994.1 - 0.093 12.8 0.4 0.093 12.8 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2752) zf-C2H2 PF00096.26 EKE41994.1 - 0.1 13.1 2.3 2.6 8.7 0.3 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf_C2H2_13 PF18508.1 EKE41994.1 - 0.11 12.1 2.9 0.22 11.1 0.1 2.5 3 0 0 3 3 3 0 Zinc finger domain DUF2845 PF11006.8 EKE41994.1 - 0.11 12.6 0.8 0.14 12.3 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2845) TFIIS_C PF01096.18 EKE41994.1 - 0.11 12.3 0.4 0.11 12.3 0.4 2.4 2 1 1 3 3 2 0 Transcription factor S-II (TFIIS) zinc_ribbon_4 PF13717.6 EKE41994.1 - 0.12 12.3 5.7 0.86 9.6 0.1 2.6 3 0 0 3 3 2 0 zinc-ribbon domain CpXC PF14353.6 EKE41994.1 - 0.13 12.4 4.4 0.42 10.7 0.2 2.1 1 1 1 2 2 2 0 CpXC protein Nudix_N_2 PF14803.6 EKE41994.1 - 0.15 12.0 4.2 4.8 7.2 0.5 2.4 2 0 0 2 2 2 0 Nudix N-terminal zf-TFIIB PF13453.6 EKE41994.1 - 0.18 11.2 3.1 0.32 10.3 3.1 1.5 1 1 0 1 1 1 0 Transcription factor zinc-finger zf_UBZ PF18439.1 EKE41994.1 - 0.22 11.1 5.9 1.9 8.1 0.1 2.6 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Zn_ribbon_recom PF13408.6 EKE41994.1 - 0.23 12.0 4.9 3.4 8.3 0.5 2.1 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain zf-CCHC_3 PF13917.6 EKE41994.1 - 0.31 11.0 0.4 0.31 11.0 0.4 2.6 3 0 0 3 3 3 0 Zinc knuckle zinc_ribbon_10 PF10058.9 EKE41994.1 - 0.48 10.2 3.6 5.7 6.8 0.4 2.2 1 1 1 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Zn_ribbon_SprT PF17283.2 EKE41994.1 - 0.74 9.8 8.6 0.084 12.8 3.9 1.8 2 1 0 2 2 2 0 SprT-like zinc ribbon domain SR1P PF13790.6 EKE41994.1 - 1.4 9.1 5.8 2.5 8.3 0.4 2.4 3 0 0 3 3 2 0 SR1 protein zf-C4_Topoisom PF01396.19 EKE41994.1 - 1.8 8.4 8.6 1.1 9.0 0.5 2.5 3 0 0 3 3 2 0 Topoisomerase DNA binding C4 zinc finger DnaJ PF00226.31 EKE41996.1 - 7e-14 51.7 0.1 1.2e-13 51.0 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Lactamase_B PF00753.27 EKE41997.1 - 0.00056 20.0 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EKE41997.1 - 0.0053 16.3 0.2 0.021 14.3 0.1 1.9 2 1 1 3 3 3 1 Beta-lactamase superfamily domain DUF5383 PF17355.2 EKE41997.1 - 0.0091 16.4 0.4 0.023 15.1 0.4 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5383) Lactamase_B_3 PF13483.6 EKE41997.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Beta-lactamase superfamily domain RhoGAP PF00620.27 EKE41998.1 - 9.9e-08 31.9 0.4 1.2e-07 31.7 0.4 1.0 1 0 0 1 1 1 1 RhoGAP domain WD40 PF00400.32 EKE41999.1 - 1.7e-24 85.6 16.4 3.8e-09 37.0 0.3 6.9 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE41999.1 - 1e-13 51.3 2.4 1.8e-05 24.9 0.1 6.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EKE41999.1 - 6.6e-06 25.9 4.2 0.15 12.0 0.0 4.9 4 1 0 4 4 4 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EKE41999.1 - 1.9e-05 23.8 0.2 0.38 9.7 0.0 4.1 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EKE41999.1 - 0.0026 17.1 0.0 3.2 7.0 0.0 3.3 3 0 0 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Adaptin_N PF01602.20 EKE42002.1 - 7.8e-38 130.3 22.5 1.9e-37 129.0 22.5 1.6 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 EKE42002.1 - 0.00049 20.4 0.0 0.21 12.0 0.0 3.1 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 EKE42002.1 - 0.0029 17.7 0.0 0.5 10.8 0.0 3.6 3 0 0 3 3 3 1 HEAT repeat Cnd1 PF12717.7 EKE42002.1 - 0.028 14.5 0.1 0.028 14.5 0.1 3.9 4 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 EKE42002.1 - 5.6 7.1 15.2 13 5.9 0.1 5.5 6 0 0 6 6 6 0 V-ATPase subunit H PUNUT PF16913.5 EKE42003.1 - 3.2e-07 29.9 12.3 3.2e-07 29.9 12.3 2.0 2 1 0 2 2 2 1 Purine nucleobase transmembrane transport EamA PF00892.20 EKE42003.1 - 1.1e-05 25.6 11.4 1.1e-05 25.6 11.4 3.4 2 2 0 2 2 2 1 EamA-like transporter family Nuc_sug_transp PF04142.15 EKE42003.1 - 5.1e-05 22.6 5.7 5.1e-05 22.6 5.7 1.9 1 1 1 2 2 2 1 Nucleotide-sugar transporter Atthog PF18800.1 EKE42003.1 - 0.027 14.4 0.3 0.027 14.4 0.3 2.7 3 0 0 3 3 3 0 Attenuator of Hedgehog CRT-like PF08627.10 EKE42003.1 - 0.03 13.3 26.9 0.46 9.4 27.0 2.3 1 1 0 1 1 1 0 CRT-like, chloroquine-resistance transporter-like DUF998 PF06197.13 EKE42003.1 - 1.6 8.3 12.5 0.068 12.8 0.5 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF998) DNA_pol_D_N PF18018.1 EKE42004.1 - 2.3e-21 76.3 0.0 4.1e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 EKE42004.1 - 2.4e-21 76.1 2.1 3.7e-21 75.4 2.1 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Peptidase_C54 PF03416.19 EKE42005.1 - 6.3e-70 235.7 0.0 7.7e-70 235.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 EKE42005.1 - 0.0015 18.1 0.1 0.006 16.1 0.1 1.9 2 0 0 2 2 2 1 Peptidase family C78 MCM PF00493.23 EKE42006.1 - 2.1e-95 318.1 0.1 3.5e-95 317.4 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 EKE42006.1 - 5.4e-24 84.4 0.9 1.6e-23 82.9 0.9 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 EKE42006.1 - 6.5e-24 84.2 0.3 1.4e-23 83.1 0.0 1.7 2 0 0 2 2 2 1 MCM OB domain Mg_chelatase PF01078.21 EKE42006.1 - 2.7e-08 33.4 0.1 1.4e-06 27.9 0.0 2.3 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EKE42006.1 - 8e-05 22.5 0.1 0.00019 21.3 0.1 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EKE42006.1 - 0.00062 19.5 0.0 0.0019 17.9 0.0 1.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA PF00004.29 EKE42006.1 - 0.13 12.7 0.2 2.1 8.8 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Pkinase PF00069.25 EKE42007.1 - 3.5e-65 220.0 0.0 2e-64 217.5 0.0 2.0 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42007.1 - 4.6e-45 153.9 0.0 1.9e-44 151.9 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE42007.1 - 2.2e-06 27.2 0.0 4.4e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EKE42007.1 - 3.4e-05 22.8 0.1 7.6e-05 21.7 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EKE42007.1 - 0.0003 20.8 0.0 0.00044 20.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pepsin-I3 PF06394.13 EKE42007.1 - 0.0098 16.1 0.4 1.7 8.9 0.0 2.7 2 0 0 2 2 2 1 Pepsin inhibitor-3-like repeated domain Kdo PF06293.14 EKE42007.1 - 0.054 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EKE42007.1 - 0.12 11.4 0.1 0.29 10.1 0.0 1.5 2 0 0 2 2 2 0 Seadornavirus VP7 PIP49_C PF12260.8 EKE42007.1 - 0.16 11.6 0.0 0.16 11.6 0.0 2.4 2 1 0 2 2 2 0 Protein-kinase domain of FAM69 zf-C3HC4_3 PF13920.6 EKE42008.1 - 1.3e-06 28.2 13.2 1.3e-06 28.2 13.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE42008.1 - 0.00017 21.4 13.9 0.00037 20.3 13.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 H_lectin PF09458.10 EKE42008.1 - 0.00023 21.3 0.7 0.0016 18.6 0.0 2.7 3 0 0 3 3 3 1 H-type lectin domain zinc_ribbon_2 PF13240.6 EKE42008.1 - 0.029 14.1 2.3 0.071 12.9 2.3 1.6 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.7 EKE42008.1 - 1.6 8.8 9.5 4.2 7.5 8.0 2.2 2 0 0 2 2 2 0 Double zinc ribbon zf-RING_5 PF14634.6 EKE42008.1 - 1.7 8.6 17.2 0.56 10.2 13.5 2.1 2 0 0 2 2 2 0 zinc-RING finger domain TLD PF07534.16 EKE42010.1 - 3.3e-09 37.1 1.6 6e-09 36.3 1.6 1.4 1 0 0 1 1 1 1 TLD DUF1899 PF08953.11 EKE42011.1 - 5.5e-25 87.0 0.3 9.3e-25 86.3 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.32 EKE42011.1 - 3.8e-12 46.5 2.4 3.4e-05 24.5 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE42011.1 - 0.088 13.1 0.0 1.9 8.8 0.0 2.4 1 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ank_2 PF12796.7 EKE42012.1 - 1.1e-16 61.1 4.1 2.2e-09 37.8 0.5 3.0 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKE42012.1 - 1.2e-12 46.8 2.6 0.00041 20.6 0.1 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EKE42012.1 - 2.5e-11 43.9 1.7 0.00014 22.4 0.1 4.4 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE42012.1 - 2.1e-10 40.6 0.9 0.00039 20.7 0.1 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EKE42012.1 - 7e-08 32.6 1.3 0.00046 20.5 0.1 4.6 4 0 0 4 4 4 1 Ankyrin repeat DUF3447 PF11929.8 EKE42012.1 - 0.0039 17.1 0.5 0.0039 17.1 0.5 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3447) SAM_Exu PF18609.1 EKE42012.1 - 0.082 13.0 6.3 3.6 7.7 0.4 3.5 3 0 0 3 3 3 0 Exuperantia SAM-like domain PBECR1 PF18809.1 EKE42012.1 - 1.4 9.6 5.7 0.45 11.2 1.1 2.6 2 0 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 AAA PF00004.29 EKE42013.1 - 1.9e-13 51.0 0.0 3.1e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EKE42013.1 - 1.6e-12 47.5 0.0 8.2e-10 38.7 0.0 2.6 2 1 0 2 2 2 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 EKE42013.1 - 2.4e-11 43.9 0.1 5e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_22 PF13401.6 EKE42013.1 - 3.1e-07 30.7 0.1 0.015 15.5 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_14 PF13173.6 EKE42013.1 - 1.9e-06 27.9 0.0 1.1e-05 25.5 0.0 2.0 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EKE42013.1 - 4.1e-05 23.1 0.0 0.00018 20.9 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 EKE42013.1 - 7e-05 22.6 0.0 0.00041 20.1 0.0 2.1 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EKE42013.1 - 7.6e-05 22.7 0.0 0.00022 21.2 0.0 1.7 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_24 PF13479.6 EKE42013.1 - 0.00018 21.3 0.0 0.00029 20.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EKE42013.1 - 0.00026 21.4 0.1 0.0019 18.6 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 EKE42013.1 - 0.0017 18.2 0.0 0.0078 16.0 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 EKE42013.1 - 0.0037 17.6 0.0 0.035 14.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EKE42013.1 - 0.0067 16.2 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EKE42013.1 - 0.007 16.4 0.0 0.044 13.8 0.0 2.0 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 EKE42013.1 - 0.011 15.5 0.0 0.023 14.4 0.0 1.6 2 0 0 2 2 1 0 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 EKE42013.1 - 0.02 14.7 0.5 8.3 6.1 0.0 2.8 2 1 1 3 3 3 0 DEAD/DEAH box helicase AAA_5 PF07728.14 EKE42013.1 - 0.033 14.2 0.0 0.067 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 EKE42013.1 - 0.045 12.8 0.0 0.076 12.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 EKE42013.1 - 0.051 13.2 0.0 0.13 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EKE42013.1 - 0.069 13.3 0.0 0.29 11.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EKE42013.1 - 0.071 12.6 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EKE42013.1 - 0.16 12.4 0.0 0.48 10.8 0.0 1.9 1 1 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 EKE42013.1 - 0.17 11.6 0.0 0.37 10.5 0.0 1.5 1 1 0 1 1 1 0 IstB-like ATP binding protein RecR PF02132.15 EKE42013.1 - 0.37 10.4 2.9 1.6 8.3 0.1 2.6 2 0 0 2 2 2 0 RecR protein Mating_N PF12731.7 EKE42014.1 - 0.0075 16.3 0.4 1.5 9.0 0.1 3.2 3 0 0 3 3 3 1 Mating-type protein beta 1 GAS PF13851.6 EKE42014.1 - 0.0078 15.6 5.8 0.0095 15.3 4.6 1.7 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding IF-2B PF01008.17 EKE42014.1 - 0.062 12.5 0.4 0.1 11.8 0.0 1.5 2 0 0 2 2 2 0 Initiation factor 2 subunit family DUF2481 PF10654.9 EKE42014.1 - 0.073 13.1 1.1 0.19 11.7 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) HAP1_N PF04849.13 EKE42014.1 - 0.09 12.0 4.4 0.03 13.5 1.6 1.5 2 0 0 2 2 2 0 HAP1 N-terminal conserved region DivIC PF04977.15 EKE42014.1 - 0.24 11.2 2.4 0.41 10.5 1.6 1.7 2 0 0 2 2 2 0 Septum formation initiator FlxA PF14282.6 EKE42014.1 - 6 6.9 7.9 0.6 10.1 2.4 2.0 2 0 0 2 2 2 0 FlxA-like protein I_LWEQ PF01608.17 EKE42015.1 - 4.1e-32 111.5 6.2 4.1e-32 111.5 6.2 6.6 5 2 2 8 8 8 1 I/LWEQ domain FERM_M PF00373.18 EKE42015.1 - 4e-10 40.1 3.1 1.2e-09 38.6 0.1 3.4 3 0 0 3 3 3 1 FERM central domain FERM_N PF09379.10 EKE42015.1 - 3.1e-09 36.6 0.6 2.8e-08 33.6 0.3 2.8 2 0 0 2 2 2 1 FERM N-terminal domain FERM_f0 PF16511.5 EKE42015.1 - 0.0019 18.5 0.4 0.0091 16.3 0.4 2.3 1 0 0 1 1 1 1 N-terminal or F0 domain of Talin-head FERM YcgR PF07317.12 EKE42015.1 - 0.054 13.4 0.4 0.61 10.0 0.3 2.9 2 0 0 2 2 2 0 Flagellar regulator YcgR Ras PF00071.22 EKE42016.1 - 5.4e-11 42.4 0.0 7e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Ras family DUF4940 PF16298.5 EKE42016.1 - 0.0099 15.6 0.7 0.012 15.3 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4940) MMR_HSR1_Xtn PF16897.5 EKE42016.1 - 0.03 14.4 2.2 0.031 14.3 0.8 1.7 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain Rhomboid PF01694.22 EKE42017.1 - 1.1e-07 32.0 12.7 1.1e-07 32.0 12.7 2.1 2 1 1 3 3 3 1 Rhomboid family SPC25 PF06703.11 EKE42017.1 - 6.8 6.5 6.7 4.2 7.2 4.2 2.0 2 1 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DnaJ PF00226.31 EKE42018.1 - 6.7e-19 67.8 0.2 6.7e-19 67.8 0.2 2.4 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-binding PF00249.31 EKE42018.1 - 9.6e-09 35.3 1.9 1.6e-06 28.2 0.6 4.0 4 0 0 4 4 4 2 Myb-like DNA-binding domain COMM_domain PF07258.14 EKE42019.1 - 3.1e-06 27.2 0.0 6.7e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 COMM domain DUF1230 PF06799.11 EKE42020.1 - 0.0057 16.8 0.5 0.0057 16.8 0.5 2.3 2 1 1 3 3 3 1 Conserved in the green lineage and diatoms 27 UDG PF03167.19 EKE42021.1 - 5.9e-19 68.6 0.0 7.6e-19 68.2 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily sCache_2 PF17200.4 EKE42021.1 - 0.058 13.2 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Single Cache domain 2 Ras PF00071.22 EKE42022.1 - 5.6e-10 39.0 1.9 2.3e-08 33.8 1.6 2.6 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EKE42022.1 - 5.6e-05 23.3 0.4 0.00037 20.7 0.1 2.2 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RhoGAP PF00620.27 EKE42022.1 - 0.17 11.7 4.9 0.42 10.4 2.1 2.3 2 0 0 2 2 2 0 RhoGAP domain zf-C3HC4_3 PF13920.6 EKE42022.1 - 0.74 9.7 17.5 35 4.4 17.8 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE42022.1 - 1.8 8.5 13.9 1.1 9.1 4.1 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 eIF3_subunit PF08597.10 EKE42023.1 - 2.2e-23 83.4 20.1 2.5e-23 83.2 20.1 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Csm1_N PF18504.1 EKE42024.1 - 1.8 9.0 47.3 1.8 9.0 4.4 5.5 3 1 2 5 5 5 0 Csm1 N-terminal domain Erf4 PF10256.9 EKE42024.1 - 4 7.6 9.6 0.17 12.0 0.6 2.8 2 1 1 3 3 3 0 Golgin subfamily A member 7/ERF4 family GDPD PF03009.17 EKE42025.1 - 1.6e-26 93.6 0.0 1.1e-25 90.9 0.0 1.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ephrin_rec_like PF07699.13 EKE42026.1 - 1.8e-09 37.2 13.1 2.9e-08 33.3 2.9 5.6 1 1 5 6 6 6 3 Putative ephrin-receptor like NCD3G PF07562.14 EKE42026.1 - 5.7e-05 23.0 40.3 0.12 12.3 2.5 5.5 4 1 1 5 5 5 4 Nine Cysteines Domain of family 3 GPCR EphA2_TM PF14575.6 EKE42026.1 - 0.00067 20.5 2.3 0.0024 18.7 2.3 2.0 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EKE42026.1 - 0.015 15.2 3.9 0.026 14.4 3.9 1.3 1 0 0 1 1 1 0 TMEM154 protein family Protocadherin PF08374.11 EKE42026.1 - 0.017 15.1 1.0 0.026 14.5 1.0 1.2 1 0 0 1 1 1 0 Protocadherin PGG PF13962.6 EKE42026.1 - 0.024 14.4 0.2 0.04 13.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function Ninjurin PF04923.12 EKE42026.1 - 0.025 14.5 1.6 0.047 13.6 1.6 1.4 1 0 0 1 1 1 0 Ninjurin DUF3149 PF11346.8 EKE42026.1 - 0.027 14.1 3.3 0.027 14.1 3.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) Chordopox_A13L PF05961.11 EKE42026.1 - 0.029 14.6 3.1 0.055 13.7 3.1 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein FAM176 PF14851.6 EKE42026.1 - 0.061 13.0 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 FAM176 family Cadherin_C_2 PF16492.5 EKE42026.1 - 0.089 13.6 0.9 0.089 13.6 0.9 2.2 2 1 0 2 2 1 0 Cadherin cytoplasmic C-terminal Rax2 PF12768.7 EKE42026.1 - 0.11 11.9 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF5385 PF17359.2 EKE42026.1 - 0.12 11.9 6.7 0.19 11.3 6.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5385) MAP17 PF15807.5 EKE42026.1 - 0.15 12.3 1.3 0.28 11.4 1.3 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF2681 PF10883.8 EKE42026.1 - 0.15 12.5 1.4 0.23 11.9 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) ECSCR PF15820.5 EKE42026.1 - 0.16 11.8 7.1 0.031 14.1 2.7 2.1 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator TNFR_c6 PF00020.18 EKE42026.1 - 0.29 11.6 0.3 0.29 11.6 0.3 7.5 2 2 1 4 4 3 0 TNFR/NGFR cysteine-rich region Baculo_11_kDa PF06143.11 EKE42026.1 - 6.6 6.4 10.3 0.24 11.0 4.2 1.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family RD3 PF14473.6 EKE42027.1 - 0.0027 17.5 0.5 0.0031 17.4 0.5 1.1 1 0 0 1 1 1 1 RD3 protein AcMNPV_Ac109 PF05054.12 EKE42027.1 - 0.022 13.9 0.2 0.022 13.9 0.2 1.1 1 0 0 1 1 1 0 Autographa californica nuclear polyhedrosis virus (AcMNPV) protein LRR_5 PF13306.6 EKE42028.1 - 1.3e-141 464.8 106.9 2.4e-29 101.9 14.7 8.2 5 2 3 8 8 8 8 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE42028.1 - 3.2e-28 97.3 0.7 0.0022 17.7 0.0 11.9 8 3 3 12 12 12 11 Leucine rich repeat UBA PF00627.31 EKE42030.1 - 0.0036 17.2 0.5 0.015 15.2 0.0 2.2 2 0 0 2 2 2 1 UBA/TS-N domain ubiquitin PF00240.23 EKE42030.1 - 0.056 13.2 0.4 0.14 12.0 0.4 1.7 1 0 0 1 1 1 0 Ubiquitin family VWA_2 PF13519.6 EKE42031.1 - 1.9e-19 70.3 0.1 2.4e-18 66.7 0.0 2.6 2 1 1 3 3 3 1 von Willebrand factor type A domain Ssl1 PF04056.14 EKE42031.1 - 9.4e-08 32.1 0.0 1.7e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.20 EKE42031.1 - 7.9e-07 28.6 9.1 0.059 13.3 2.9 3.8 3 0 0 3 3 3 2 Ubiquitin interaction motif VWA PF00092.28 EKE42031.1 - 2.3e-05 24.7 2.0 4.6e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain zf-Nse PF11789.8 EKE42032.1 - 0.0026 17.5 0.1 0.01 15.7 0.1 2.0 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF3385 PF11865.8 EKE42033.1 - 4.6e-34 117.7 0.2 4.6e-34 117.7 0.2 5.4 4 3 2 6 6 6 2 Domain of unknown function (DUF3385) HEAT PF02985.22 EKE42033.1 - 5.6e-07 29.3 0.0 0.51 10.7 0.0 6.6 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.6 EKE42033.1 - 1.8e-06 28.2 0.0 0.075 13.4 0.0 4.7 5 1 0 5 5 5 2 HEAT repeats UME PF08064.13 EKE42033.1 - 4.3e-05 23.4 4.9 3.1 7.7 0.1 5.4 3 1 1 4 4 4 3 UME (NUC010) domain HEAT_EZ PF13513.6 EKE42033.1 - 0.00036 21.0 0.0 13 6.5 0.0 5.8 5 0 0 5 5 5 1 HEAT-like repeat CLASP_N PF12348.8 EKE42033.1 - 0.0014 18.3 7.2 1.6 8.2 0.0 5.5 3 1 1 5 5 5 1 CLASP N terminal Cnd1 PF12717.7 EKE42033.1 - 0.003 17.6 0.5 0.003 17.6 0.5 4.7 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Xpo1 PF08389.12 EKE42033.1 - 0.0068 16.5 13.8 0.5 10.4 0.1 5.8 6 1 0 6 6 5 2 Exportin 1-like protein Tti2 PF10521.9 EKE42033.1 - 0.019 14.5 2.1 0.29 10.6 0.2 3.3 2 0 0 2 2 2 0 Tti2 family TraD PF06412.11 EKE42033.1 - 0.025 14.4 0.1 0.12 12.2 0.0 2.1 2 0 0 2 2 2 0 Conjugal transfer protein TraD IFRD PF05004.13 EKE42033.1 - 0.032 13.3 0.4 0.34 10.0 0.0 2.8 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) UNC45-central PF11701.8 EKE42033.1 - 0.054 13.5 3.4 19 5.2 0.1 4.0 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central SopA PF13981.6 EKE42033.1 - 0.062 13.7 1.0 0.55 10.7 0.3 3.0 2 0 0 2 2 2 0 SopA-like central domain MOR2-PAG1_C PF14225.6 EKE42033.1 - 0.11 12.3 15.8 0.064 13.1 0.6 4.3 4 1 0 4 4 4 0 Cell morphogenesis C-terminal HIM1 PF08732.10 EKE42034.1 - 0.18 11.3 2.8 0.61 9.6 2.8 1.8 1 1 0 1 1 1 0 HIM1 DNA_pol3_delta2 PF13177.6 EKE42035.1 - 2.2e-09 37.3 0.2 9.8e-09 35.2 0.2 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 EKE42035.1 - 0.00037 20.8 0.0 0.00081 19.8 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain TPR_14 PF13428.6 EKE42036.1 - 3.3e-12 46.1 0.7 0.16 12.9 0.0 7.3 4 3 3 7 7 7 2 Tetratricopeptide repeat Suf PF05843.14 EKE42036.1 - 6.9e-10 39.4 30.7 3e-05 24.1 3.7 5.4 1 1 2 4 4 4 2 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EKE42036.1 - 1.3e-08 35.2 0.1 1.2e-05 25.7 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EKE42036.1 - 3.7e-05 23.7 24.9 0.0077 16.2 6.7 4.7 2 1 2 4 4 4 2 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 EKE42036.1 - 0.00036 20.4 8.2 0.17 12.1 0.0 5.4 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EKE42036.1 - 0.00084 19.4 1.4 81 3.8 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat RmuC PF02646.16 EKE42036.1 - 0.0093 15.1 0.2 0.019 14.1 0.2 1.5 1 0 0 1 1 1 1 RmuC family HAT PF02184.16 EKE42036.1 - 0.036 14.0 27.9 2.1 8.4 0.3 7.3 6 1 0 6 6 6 0 HAT (Half-A-TPR) repeat TPR_12 PF13424.6 EKE42036.1 - 0.18 12.1 3.7 2.3 8.6 0.2 4.0 5 1 0 5 5 4 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EKE42036.1 - 0.44 10.7 21.9 0.82 9.8 0.7 5.7 5 2 1 6 6 6 0 U3 small nucleolar RNA-associated protein 6 TPR_17 PF13431.6 EKE42036.1 - 0.75 10.3 8.1 12 6.5 0.0 4.6 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EKE42036.1 - 1.5 9.6 4.9 17 6.3 0.2 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat GCD14 PF08704.10 EKE42037.1 - 2.4e-47 161.7 0.0 2.7e-43 148.4 0.0 2.0 1 1 1 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_24 PF13578.6 EKE42037.1 - 0.0007 20.6 0.0 0.00099 20.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain AHD PF17793.1 EKE42038.1 - 0.94 9.3 11.0 2.5 8.0 0.1 3.7 3 0 0 3 3 3 0 ANC1 homology domain (AHD) MMPL PF03176.15 EKE42039.1 - 8.2e-68 228.8 0.1 1.3e-34 119.6 0.0 2.5 2 1 0 2 2 2 2 MMPL family Cyclin_N PF00134.23 EKE42040.1 - 2e-37 127.8 1.7 7.6e-34 116.2 0.8 2.2 1 1 1 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 EKE42040.1 - 2.1e-26 92.3 0.1 3.6e-26 91.6 0.1 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain Rpn9_C PF18261.1 EKE42040.1 - 0.081 12.5 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 Rpn9 C-terminal helix DUF4969 PF16339.5 EKE42042.1 - 0.012 16.0 1.5 0.056 13.8 0.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4969) PsbU PF06514.11 EKE42042.1 - 0.1 12.6 0.8 13 5.9 0.2 2.7 2 1 0 2 2 2 0 Photosystem II 12 kDa extrinsic protein (PsbU) DUF1542 PF07564.11 EKE42042.1 - 0.71 10.0 25.5 0.38 10.9 5.4 3.3 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1542) Abhydrolase_1 PF00561.20 EKE42043.1 - 8.7e-09 35.4 0.0 1.2e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EKE42043.1 - 6.9e-05 22.2 0.0 9e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Tantalus PF15386.6 EKE42043.1 - 0.099 12.8 0.3 0.23 11.6 0.3 1.5 1 0 0 1 1 1 0 Drosophila Tantalus-like Tup_N PF08581.10 EKE42044.1 - 0.0008 19.7 7.6 0.00096 19.4 7.0 1.5 1 1 0 1 1 1 1 Tup N-terminal CENP-F_leu_zip PF10473.9 EKE42044.1 - 0.0025 17.9 9.2 0.0029 17.6 9.2 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF812 PF05667.11 EKE42044.1 - 0.0075 15.2 5.9 0.0078 15.1 5.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) ZapB PF06005.12 EKE42044.1 - 0.015 15.7 10.6 0.015 15.7 10.6 1.8 1 1 1 2 2 2 0 Cell division protein ZapB DUF745 PF05335.13 EKE42044.1 - 0.059 13.1 3.0 0.07 12.8 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Tho2 PF11262.8 EKE42044.1 - 0.087 12.0 5.5 0.1 11.8 5.5 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Occludin_ELL PF07303.13 EKE42044.1 - 0.089 13.5 6.0 0.13 13.0 6.0 1.2 1 0 0 1 1 1 0 Occludin homology domain HMMR_N PF15905.5 EKE42044.1 - 0.1 12.1 10.5 0.11 11.9 10.5 1.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Atg14 PF10186.9 EKE42044.1 - 0.16 11.0 6.8 0.17 11.0 6.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 GrpE PF01025.19 EKE42044.1 - 0.35 10.5 6.9 0.24 11.1 5.1 1.6 1 1 1 2 2 2 0 GrpE LMBR1 PF04791.16 EKE42044.1 - 0.42 9.5 4.9 0.48 9.3 4.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein MRP-S26 PF14943.6 EKE42044.1 - 0.63 9.9 10.6 0.77 9.6 10.6 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 SlyX PF04102.12 EKE42044.1 - 0.86 10.3 9.7 7.4 7.3 5.8 2.8 1 1 2 3 3 3 0 SlyX YabA PF06156.13 EKE42044.1 - 2.3 8.9 7.1 4.7 7.9 6.7 1.8 1 1 0 1 1 1 0 Initiation control protein YabA FapA PF03961.13 EKE42044.1 - 2.9 6.4 7.8 3.1 6.3 7.8 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Ras PF00071.22 EKE42047.1 - 1.4e-15 57.3 0.6 1.6e-15 57.1 0.6 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42047.1 - 0.00035 20.8 0.0 0.0005 20.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase T3RM_EcoP15I_C PF18273.1 EKE42047.1 - 0.0072 16.6 1.2 0.016 15.5 0.4 2.1 1 1 1 2 2 2 1 Type III R-M EcoP15I C-terminal domain Dynamin_N PF00350.23 EKE42047.1 - 0.019 15.1 0.0 0.027 14.6 0.0 1.3 1 0 0 1 1 1 0 Dynamin family GTP_EFTU PF00009.27 EKE42047.1 - 0.02 14.4 0.1 0.027 14.0 0.1 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE42047.1 - 0.068 13.3 0.0 0.12 12.4 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Beta-Casp PF10996.8 EKE42048.1 - 2.7e-07 30.9 0.9 4.2e-07 30.2 0.0 1.8 2 0 0 2 2 2 1 Beta-Casp domain CPSF100_C PF13299.6 EKE42048.1 - 2.8e-07 30.9 11.3 4.6e-06 26.9 0.1 3.2 2 1 1 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal SURF2 PF05477.11 EKE42048.1 - 0.23 11.2 7.3 0.33 10.6 7.3 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Vfa1 PF08432.10 EKE42048.1 - 1.6 9.1 11.0 2.9 8.2 11.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 YabA PF06156.13 EKE42048.1 - 3.7 8.2 13.0 14 6.4 12.0 2.3 2 0 0 2 2 2 0 Initiation control protein YabA RNA_pol_3_Rpc31 PF11705.8 EKE42048.1 - 4.2 7.6 15.9 80 3.4 15.0 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Flavokinase PF01687.17 EKE42049.1 - 7.3e-30 103.5 0.6 8.1e-30 103.4 0.6 1.0 1 0 0 1 1 1 1 Riboflavin kinase RRM_1 PF00076.22 EKE42050.1 - 7.4e-35 118.6 8.0 2.5e-09 36.8 0.4 4.8 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE42050.1 - 2.1e-05 24.4 3.4 1 9.4 0.1 4.7 5 0 0 5 5 5 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EKE42050.1 - 3.5e-05 23.8 11.9 0.0064 16.5 1.9 4.3 3 1 0 4 4 4 2 RNA binding motif RRM_7 PF16367.5 EKE42050.1 - 0.00019 21.5 1.1 0.69 10.1 0.0 3.8 4 0 0 4 4 4 1 RNA recognition motif PABP PF00658.18 EKE42050.1 - 0.00094 19.3 0.1 0.0025 18.0 0.1 1.7 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain sCache_2 PF17200.4 EKE42050.1 - 0.0076 16.1 3.0 2.1 8.2 0.5 3.4 3 0 0 3 3 3 2 Single Cache domain 2 Myb_DNA-bind_6 PF13921.6 EKE42050.1 - 0.075 13.3 0.2 1.3 9.3 0.0 2.6 2 0 0 2 2 2 0 Myb-like DNA-binding domain RRM_occluded PF16842.5 EKE42050.1 - 0.12 12.3 0.1 1.2 9.0 0.0 2.6 2 0 0 2 2 2 0 Occluded RNA-recognition motif MazG PF03819.17 EKE42050.1 - 0.12 12.5 0.1 6.8 7.0 0.0 2.7 2 0 0 2 2 2 0 MazG nucleotide pyrophosphohydrolase domain DUF1987 PF09345.10 EKE42050.1 - 0.18 11.5 2.5 0.37 10.5 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1987) Ribosomal_S19 PF00203.21 EKE42051.1 - 4e-33 113.1 0.5 6.6e-33 112.5 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 UTP25 PF06862.12 EKE42054.1 - 3.9e-114 382.0 15.5 6.5e-114 381.3 15.5 1.3 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF1870 PF08965.10 EKE42054.1 - 0.18 11.8 0.8 2.9 7.9 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1870) DUF3238 PF11579.8 EKE42055.1 - 0.038 13.8 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3238) Peptidase_C54 PF03416.19 EKE42056.1 - 1.3e-17 64.1 0.9 4.2e-17 62.5 0.2 1.8 1 1 1 2 2 2 1 Peptidase family C54 Lipoprotein_X PF03305.13 EKE42056.1 - 0.0037 17.0 1.6 0.0046 16.7 0.3 1.7 2 0 0 2 2 2 1 Mycoplasma MG185/MG260 protein Peptidase_C78 PF07910.13 EKE42056.1 - 0.032 13.7 2.5 0.18 11.3 2.5 2.1 1 1 0 1 1 1 0 Peptidase family C78 Abhydrolase_2 PF02230.16 EKE42057.1 - 0.081 12.7 0.1 0.24 11.2 0.0 1.7 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase HSF_DNA-bind PF00447.17 EKE42058.1 - 1.1e-26 93.2 0.9 1.6e-26 92.7 0.1 1.6 2 0 0 2 2 2 1 HSF-type DNA-binding Spc29 PF17082.5 EKE42058.1 - 0.004 17.0 0.3 0.0071 16.2 0.3 1.4 1 0 0 1 1 1 1 Spindle Pole Component 29 COG5 PF10392.9 EKE42058.1 - 0.031 14.5 0.3 6 7.0 0.1 2.4 2 0 0 2 2 2 0 Golgi transport complex subunit 5 MPS2 PF17060.5 EKE42058.1 - 0.055 12.7 1.8 0.079 12.2 1.8 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 CdiI_N PF18228.1 EKE42058.1 - 0.12 12.2 0.0 0.4 10.5 0.0 1.8 1 0 0 1 1 1 0 CdiI N-terminal domain SAC3_GANP PF03399.16 EKE42059.1 - 1.8e-19 70.2 9.0 4.8e-18 65.6 9.0 2.0 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EKE42059.1 - 8.3e-06 25.8 1.0 1.6e-05 24.9 0.2 1.8 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family EF-hand_2 PF09068.11 EKE42059.1 - 0.52 10.5 6.1 4.9 7.3 0.2 2.9 1 1 2 3 3 3 0 EF hand Bromodomain PF00439.25 EKE42060.1 - 2.2e-22 78.9 0.6 4.9e-22 77.8 0.6 1.6 1 0 0 1 1 1 1 Bromodomain RE_AccI PF09545.10 EKE42060.1 - 0.0038 16.3 0.3 0.0051 15.8 0.3 1.2 1 0 0 1 1 1 1 AccI restriction endonuclease Hat1_N PF10394.9 EKE42060.1 - 0.011 15.9 1.5 0.015 15.6 0.1 1.9 1 1 1 2 2 2 0 Histone acetyl transferase HAT1 N-terminus BP28CT PF08146.12 EKE42060.1 - 0.03 14.2 1.1 0.03 14.2 1.1 2.5 2 2 0 2 2 2 0 BP28CT (NUC211) domain PIP5K PF01504.18 EKE42061.1 - 6e-42 143.8 1.9 1.2e-30 106.7 1.3 2.5 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase IBN_N PF03810.19 EKE42062.1 - 0.016 15.1 1.3 0.15 12.0 0.3 2.8 2 0 0 2 2 2 0 Importin-beta N-terminal domain Imm6 PF14434.6 EKE42062.1 - 0.038 13.9 0.0 0.29 11.1 0.0 2.5 2 0 0 2 2 2 0 Immunity protein Imm6 HSP70 PF00012.20 EKE42063.1 - 2.5e-74 250.6 13.3 3.7e-74 250.0 13.3 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EKE42063.1 - 1.1e-09 37.6 2.6 1.6e-08 33.8 1.7 2.8 2 1 0 2 2 2 1 MreB/Mbl protein BcrAD_BadFG PF01869.20 EKE42063.1 - 8.3e-06 25.5 0.1 0.11 12.0 0.0 2.4 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family Chal_sti_synt_C PF02797.15 EKE42063.1 - 0.011 15.7 0.3 0.11 12.4 0.1 2.4 2 0 0 2 2 2 0 Chalcone and stilbene synthases, C-terminal domain Phage_FRD3 PF05798.11 EKE42063.1 - 0.09 13.1 2.0 1 9.7 0.1 3.5 4 0 0 4 4 4 0 Bacteriophage FRD3 protein FGGY_N PF00370.21 EKE42063.1 - 0.26 10.8 2.8 0.86 9.1 0.0 3.0 4 0 0 4 4 4 0 FGGY family of carbohydrate kinases, N-terminal domain Sec23_trunk PF04811.15 EKE42064.1 - 1.3e-16 60.9 0.1 3.1e-16 59.7 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EKE42064.1 - 1.7e-13 51.1 0.1 3.7e-13 50.0 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EKE42064.1 - 9.5e-09 35.2 5.6 4.8e-08 32.9 5.6 2.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger VWA PF00092.28 EKE42064.1 - 0.0024 18.1 0.2 0.0087 16.3 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EKE42064.1 - 0.013 16.1 0.0 0.037 14.7 0.0 1.8 1 1 0 1 1 1 0 von Willebrand factor type A domain PI3K_p85B PF02192.16 EKE42064.1 - 0.13 12.1 0.5 0.75 9.6 0.3 2.2 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain DUF5341 PF17276.2 EKE42064.1 - 0.48 10.6 4.0 3.8 7.7 0.3 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5341) IF-2B PF01008.17 EKE42065.1 - 7.3e-36 123.8 11.2 1.1e-33 116.6 11.2 2.3 1 1 0 1 1 1 1 Initiation factor 2 subunit family Bap31 PF05529.12 EKE42065.1 - 2e-07 30.9 3.7 6.9e-07 29.2 3.7 1.9 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region V_ATPase_I PF01496.19 EKE42065.1 - 0.0016 16.5 6.5 0.0029 15.6 6.5 1.4 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Zip PF02535.22 EKE42065.1 - 0.0035 16.6 4.6 0.0063 15.8 4.6 1.3 1 1 0 1 1 1 1 ZIP Zinc transporter Ribosomal_L34e PF01199.18 EKE42065.1 - 1 9.7 7.7 2.4 8.5 7.7 1.6 1 0 0 1 1 1 0 Ribosomal protein L34e DCP1 PF06058.13 EKE42066.1 - 1e-12 48.0 0.2 1.2e-12 47.8 0.2 1.1 1 0 0 1 1 1 1 Dcp1-like decapping family Viral_protease PF08715.10 EKE42066.1 - 0.026 13.9 0.1 0.034 13.5 0.1 1.1 1 0 0 1 1 1 0 Papain like viral protease SH2_2 PF14633.6 EKE42067.1 - 5.8e-16 58.5 0.4 5.8e-16 58.5 0.4 3.1 3 1 1 4 4 4 1 SH2 domain HHH_7 PF14635.6 EKE42067.1 - 2.4e-12 47.1 0.2 6.6e-12 45.7 0.2 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 EKE42067.1 - 0.00076 19.9 4.4 0.00076 19.9 4.4 2.6 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 Peptidase_C13 PF01650.18 EKE42068.1 - 1e-31 110.4 0.5 1.2e-31 110.2 0.5 1.1 1 0 0 1 1 1 1 Peptidase C13 family Adaptin_N PF01602.20 EKE42069.1 - 3.5e-114 382.2 13.0 4.8e-114 381.8 13.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EKE42069.1 - 5.1e-19 68.6 2.6 5.1e-19 68.6 2.6 2.5 2 0 0 2 2 2 1 Adaptin C-terminal domain V-ATPase_H_C PF11698.8 EKE42069.1 - 0.013 15.6 0.3 0.08 13.1 0.2 2.4 1 1 0 1 1 1 0 V-ATPase subunit H HEAT_2 PF13646.6 EKE42069.1 - 0.016 15.6 0.1 0.8 10.1 0.0 3.2 3 0 0 3 3 3 0 HEAT repeats Cnd1 PF12717.7 EKE42069.1 - 2.7 8.0 7.1 2.5 8.1 0.2 3.3 3 2 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 TRM13 PF05206.14 EKE42070.1 - 1.3e-36 126.5 2.2 1.5e-28 100.1 0.4 3.3 3 1 1 4 4 4 2 Methyltransferase TRM13 Methyltransf_32 PF13679.6 EKE42070.1 - 1.4e-08 34.8 0.1 1.4e-08 34.8 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase domain zf-U11-48K PF05253.12 EKE42070.1 - 1.4e-06 28.1 1.7 3.5e-06 26.8 1.7 1.7 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger Disulph_isomer PF06491.11 EKE42070.1 - 0.0026 17.9 0.0 0.0084 16.2 0.0 1.8 2 0 0 2 2 2 1 Disulphide isomerase MutS_V PF00488.21 EKE42071.1 - 1.9e-31 109.5 0.1 3.8e-31 108.6 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EKE42071.1 - 6.4e-12 46.1 2.0 2.4e-11 44.2 0.0 2.4 2 0 0 2 2 2 1 MutS domain III Fibin PF15819.5 EKE42071.1 - 0.12 12.1 2.2 13 5.5 0.0 2.6 2 0 0 2 2 2 0 Fin bud initiation factor homologue MutS_IV PF05190.18 EKE42071.1 - 1.3 9.5 10.7 5.3 7.5 0.1 4.4 4 1 0 4 4 4 0 MutS family domain IV PAP2 PF01569.21 EKE42072.1 - 1.9e-23 82.7 0.9 1.9e-23 82.7 0.9 1.9 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EKE42072.1 - 0.021 14.5 2.1 0.096 12.4 2.1 2.1 1 1 0 1 1 1 0 PAP2 superfamily NatB_MDM20 PF09797.9 EKE42073.1 - 3.5e-17 62.4 21.4 1.1e-15 57.5 21.4 3.3 1 1 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit ParBc_2 PF08857.11 EKE42073.1 - 0.17 12.0 1.5 19 5.3 0.1 2.7 2 0 0 2 2 2 0 Putative ParB-like nuclease Med16 PF11635.8 EKE42074.1 - 0.0053 14.7 4.5 0.0065 14.5 4.5 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 Polo_box_3 PF18544.1 EKE42074.1 - 0.0064 17.1 1.8 0.025 15.2 0.8 2.0 1 1 1 2 2 2 1 Polo box domain F-actin_cap_A PF01267.17 EKE42074.1 - 0.018 14.5 1.6 0.02 14.4 1.6 1.0 1 0 0 1 1 1 0 F-actin capping protein alpha subunit nsp9 PF08710.10 EKE42074.1 - 0.023 15.1 0.2 0.028 14.8 0.2 1.1 1 0 0 1 1 1 0 nsp9 replicase PAP_central PF04928.17 EKE42074.1 - 0.059 12.3 2.5 0.074 12.0 2.5 1.0 1 0 0 1 1 1 0 Poly(A) polymerase central domain Hydrolase_4 PF12146.8 EKE42077.1 - 5.9e-34 117.4 0.0 7.3e-34 117.1 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EKE42077.1 - 2e-12 47.3 0.3 1.5e-10 41.2 0.2 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKE42077.1 - 5.5e-07 30.4 0.0 7.7e-07 29.9 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EKE42077.1 - 0.0068 16.3 0.0 0.014 15.2 0.0 1.5 1 1 0 1 1 1 1 Palmitoyl protein thioesterase SRPRB PF09439.10 EKE42077.1 - 0.027 13.9 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Abhydrolase_5 PF12695.7 EKE42077.1 - 0.042 13.6 0.0 4.6 7.0 0.0 2.5 3 0 0 3 3 3 0 Alpha/beta hydrolase family DUF2684 PF10885.8 EKE42077.1 - 0.32 11.1 2.8 0.7 10.1 2.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2684) NHL PF01436.21 EKE42078.1 - 2.2e-11 43.2 0.3 0.0014 18.5 0.0 4.6 4 0 0 4 4 4 3 NHL repeat G10 PF01125.17 EKE42078.1 - 0.1 12.3 8.0 0.18 11.5 0.0 2.3 2 0 0 2 2 2 0 G10 protein RabGAP-TBC PF00566.18 EKE42079.1 - 4.4e-22 78.8 1.3 4.4e-22 78.8 1.3 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Pkinase PF00069.25 EKE42079.1 - 5.6e-14 52.1 1.6 8.6e-14 51.5 1.6 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42079.1 - 4.7e-09 35.9 1.1 1.5e-07 31.0 1.1 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase LRR_5 PF13306.6 EKE42082.1 - 4.9e-184 602.0 134.5 9.6e-34 116.1 14.5 5.4 1 1 6 7 7 7 7 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE42082.1 - 1.4e-26 92.0 16.4 0.0035 17.1 0.9 11.8 5 5 8 14 14 14 12 Leucine rich repeat Acetyltransf_19 PF18015.1 EKE42082.1 - 0.0027 17.9 6.5 0.22 11.8 0.2 4.0 3 1 1 4 4 4 2 Acetyltransferase (GNAT) domain CH PF00307.31 EKE42083.1 - 3.4e-17 62.6 6.0 5e-09 36.3 0.1 2.8 3 0 0 3 3 3 2 Calponin homology (CH) domain Sel1 PF08238.12 EKE42083.1 - 1.7e-13 50.8 3.7 0.073 13.8 0.4 6.9 7 0 0 7 7 7 3 Sel1 repeat TPR_1 PF00515.28 EKE42083.1 - 0.0058 16.4 3.0 0.43 10.5 0.0 5.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EKE42083.1 - 0.015 15.3 1.7 19 5.7 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat Hist_deacetyl PF00850.19 EKE42084.1 - 5.1e-81 272.5 0.1 8.2e-81 271.8 0.1 1.3 2 0 0 2 2 2 1 Histone deacetylase domain DENN PF02141.21 EKE42085.1 - 8.6e-22 78.0 8.7 8.6e-22 78.0 8.7 2.0 2 0 0 2 2 2 1 DENN (AEX-3) domain SPA PF08616.10 EKE42085.1 - 5.9e-07 29.4 2.4 7e-07 29.2 0.9 1.9 2 0 0 2 2 2 1 Stabilization of polarity axis dDENN PF03455.19 EKE42085.1 - 0.00074 19.5 0.3 0.0034 17.3 0.3 2.2 1 0 0 1 1 1 1 dDENN domain Avl9 PF09794.9 EKE42085.1 - 0.0048 15.7 2.5 0.45 9.2 0.7 2.4 1 1 1 2 2 2 2 Transport protein Avl9 RIO1 PF01163.22 EKE42086.1 - 1.1e-68 230.6 0.3 1.1e-68 230.6 0.3 2.9 3 0 0 3 3 3 1 RIO1 family Pkinase_fungal PF17667.1 EKE42086.1 - 0.012 14.5 0.1 0.012 14.5 0.1 2.4 2 0 0 2 2 2 0 Fungal protein kinase Prismane PF03063.20 EKE42086.1 - 0.06 12.0 2.0 0.17 10.5 1.1 2.2 2 1 0 2 2 2 0 Prismane/CO dehydrogenase family APH PF01636.23 EKE42086.1 - 0.15 11.9 0.0 2 8.3 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.32 EKE42088.1 - 3.2e-15 56.3 3.2 0.022 15.6 0.0 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE42088.1 - 1.9e-05 24.9 0.5 0.22 11.9 0.0 4.2 1 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EKE42088.1 - 0.0032 17.4 0.9 0.23 11.3 0.1 3.2 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ras PF00071.22 EKE42089.1 - 2.6e-59 199.4 0.7 3.2e-59 199.2 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42089.1 - 1.9e-34 118.4 0.1 3.4e-34 117.6 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42089.1 - 5.3e-15 55.3 0.1 6.7e-15 55.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE42089.1 - 2.3e-07 30.9 0.0 3.8e-07 30.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE42089.1 - 1.8e-06 28.0 0.1 0.047 13.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EKE42089.1 - 2.5e-06 27.2 0.2 5e-06 26.2 0.2 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE42089.1 - 4.9e-05 22.8 0.1 6.5e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EKE42089.1 - 0.00029 21.1 0.0 0.0029 17.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EKE42089.1 - 0.0017 18.8 0.0 0.0026 18.2 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 EKE42089.1 - 0.0054 16.7 0.5 0.0095 15.9 0.5 1.5 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea SRPRB PF09439.10 EKE42089.1 - 0.0063 16.0 0.0 0.016 14.7 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 EKE42089.1 - 0.0078 16.7 0.1 0.013 16.0 0.1 1.5 1 1 0 1 1 1 1 ABC transporter PduV-EutP PF10662.9 EKE42089.1 - 0.0086 15.8 0.1 0.027 14.2 0.1 1.8 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 EKE42089.1 - 0.0089 16.3 0.7 0.25 11.6 0.7 2.2 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EKE42089.1 - 0.011 15.5 0.1 0.023 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EKE42089.1 - 0.015 15.2 0.0 1.7 8.6 0.0 2.2 2 0 0 2 2 2 0 NACHT domain NTPase_1 PF03266.15 EKE42089.1 - 0.018 14.9 0.1 0.028 14.3 0.1 1.4 1 0 0 1 1 1 0 NTPase AAA_7 PF12775.7 EKE42089.1 - 0.07 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DAP3 PF10236.9 EKE42089.1 - 0.12 11.5 0.0 2.2 7.4 0.0 2.4 2 1 1 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 AAA_14 PF13173.6 EKE42089.1 - 0.13 12.3 0.1 0.38 10.8 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EKE42089.1 - 0.15 12.0 0.0 0.47 10.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PhoLip_ATPase_C PF16212.5 EKE42091.1 - 1.3e-68 231.5 31.3 1.3e-68 231.5 31.3 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EKE42091.1 - 5.9e-24 83.6 3.9 3.5e-23 81.1 3.9 2.4 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EKE42091.1 - 6e-14 52.8 0.5 3.3e-09 37.4 0.1 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EKE42091.1 - 4.7e-13 49.0 0.5 4.5e-12 45.9 0.1 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EKE42091.1 - 1.6e-12 47.3 0.3 7.8e-12 45.1 0.3 2.2 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EKE42091.1 - 0.00011 22.0 7.0 0.089 12.5 0.2 3.5 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cpta_toxin PF07254.12 EKE42091.1 - 0.53 10.3 3.2 0.42 10.6 0.2 2.3 2 0 0 2 2 2 0 Membrane-bound toxin component of toxin-antitoxin system Acetyltransf_10 PF13673.7 EKE42092.1 - 3.7e-16 59.2 0.1 4.3e-16 59.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EKE42092.1 - 4.2e-08 33.5 0.1 5.5e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EKE42092.1 - 1.6e-06 28.3 0.1 2e-06 28.0 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_5 PF13444.6 EKE42092.1 - 0.00041 21.0 0.0 0.023 15.4 0.0 2.2 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EKE42092.1 - 0.00095 19.2 0.2 0.032 14.3 0.2 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EKE42092.1 - 0.0014 18.7 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EKE42092.1 - 0.0029 17.5 0.0 0.0053 16.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_13 PF13880.6 EKE42092.1 - 0.0062 16.5 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 EKE42092.1 - 0.009 15.5 0.5 0.019 14.4 0.4 1.7 1 1 0 1 1 1 1 Putative acetyl-transferase SHQ1 PF04925.15 EKE42092.1 - 0.029 13.9 0.3 0.052 13.1 0.1 1.5 2 0 0 2 2 2 0 SHQ1 protein PanZ PF12568.8 EKE42092.1 - 0.15 11.7 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ ANAPC4_WD40 PF12894.7 EKE42093.1 - 0.00068 19.9 0.0 20 5.5 0.0 3.7 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DRMBL PF07522.14 EKE42094.1 - 2.1e-16 60.0 0.2 4.2e-16 59.1 0.2 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_6 PF16661.5 EKE42094.1 - 0.00097 18.6 0.0 0.002 17.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 EKE42094.1 - 0.0082 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EKE42094.1 - 0.046 13.2 0.0 0.087 12.3 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain RabGAP-TBC PF00566.18 EKE42095.1 - 6.6e-39 133.8 5.7 9.4e-39 133.3 5.7 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain TRAM1 PF08390.11 EKE42095.1 - 0.015 15.0 0.2 0.031 13.9 0.2 1.5 1 0 0 1 1 1 0 TRAM1-like protein adh_short PF00106.25 EKE42096.1 - 1.4e-35 122.5 0.0 2e-35 122.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EKE42096.1 - 2.4e-23 82.9 0.0 3.2e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EKE42096.1 - 1.1e-11 45.0 0.0 2.5e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EKE42096.1 - 0.0044 16.4 0.0 0.0082 15.5 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain F420_oxidored PF03807.17 EKE42096.1 - 0.0063 17.1 0.0 0.013 16.1 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.15 EKE42096.1 - 0.014 14.6 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Glyco_tran_WecB PF03808.13 EKE42096.1 - 0.047 13.6 0.0 0.11 12.4 0.0 1.5 1 1 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family NAD_binding_2 PF03446.15 EKE42096.1 - 0.065 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Epimerase PF01370.21 EKE42096.1 - 0.071 12.5 0.0 0.099 12.1 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family LapA_dom PF06305.11 EKE42096.1 - 1.5 8.7 3.4 1.6 8.6 1.6 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Tmemb_185A PF10269.9 EKE42097.1 - 0.00046 20.0 17.9 0.0096 15.6 4.9 3.1 2 1 0 2 2 2 2 Transmembrane Fragile-X-F protein F-box-like PF12937.7 EKE42097.1 - 0.023 14.6 0.3 0.057 13.3 0.3 1.8 1 0 0 1 1 1 0 F-box-like Rad1 PF02144.16 EKE42098.1 - 2.2e-12 46.7 5.0 3.4e-06 26.3 0.2 2.2 1 1 0 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Ank_2 PF12796.7 EKE42099.1 - 1.9e-17 63.6 0.0 1.3e-07 32.1 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKE42099.1 - 5.7e-13 47.8 0.0 0.0012 19.2 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Patatin PF01734.22 EKE42099.1 - 7e-13 49.2 0.0 2.4e-12 47.5 0.0 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase Ank_4 PF13637.6 EKE42099.1 - 1.7e-09 38.1 0.0 8.6e-05 23.0 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE42099.1 - 3.5e-09 36.8 0.0 0.022 15.1 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EKE42099.1 - 3.3e-06 27.3 0.0 0.011 16.1 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat tRNA-synt_1b PF00579.25 EKE42101.1 - 0.026 13.9 0.0 0.07 12.4 0.0 1.7 1 1 0 1 1 1 0 tRNA synthetases class I (W and Y) RRM_1 PF00076.22 EKE42101.1 - 0.041 13.7 0.3 2.5 8.0 0.1 2.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec20 PF03908.13 EKE42101.1 - 1.1 9.2 7.8 17 5.4 2.0 3.7 3 1 0 3 3 3 0 Sec20 KAP PF05804.12 EKE42102.1 - 1.9e-11 42.9 19.9 3.7e-05 22.1 2.0 4.1 1 1 0 3 3 3 3 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 EKE42102.1 - 0.00058 19.2 9.6 0.54 9.5 0.7 4.0 1 1 1 3 3 3 3 V-ATPase subunit H RICTOR_V PF14668.6 EKE42102.1 - 0.019 15.2 2.4 15 5.9 0.0 5.4 3 2 3 6 6 6 0 Rapamycin-insensitive companion of mTOR, domain 5 ATP-synt_F PF01990.17 EKE42102.1 - 0.036 14.4 2.6 0.39 11.1 0.5 3.3 2 1 0 2 2 2 0 ATP synthase (F/14-kDa) subunit Abhydrolase_1 PF00561.20 EKE42103.1 - 1.9e-08 34.3 0.1 4.8e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EKE42103.1 - 4.1e-08 34.1 0.0 5.4e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EKE42103.1 - 7.8e-08 31.9 0.0 1.2e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EKE42103.1 - 0.00053 19.8 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Thioesterase PF00975.20 EKE42103.1 - 0.0037 17.4 0.0 0.0054 16.9 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Cutinase PF01083.22 EKE42103.1 - 0.047 13.6 0.4 0.084 12.8 0.4 1.3 1 0 0 1 1 1 0 Cutinase DUF818 PF05677.12 EKE42103.1 - 0.095 11.6 0.4 0.18 10.7 0.4 1.3 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) RabGAP-TBC PF00566.18 EKE42105.1 - 1.7e-24 86.7 8.1 1.7e-24 86.7 8.1 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain LSM PF01423.22 EKE42107.1 - 8.2e-15 54.3 0.6 1.3e-14 53.6 0.6 1.2 1 0 0 1 1 1 1 LSM domain Ycf4 PF02392.16 EKE42108.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 Ycf4 MCC-bdg_PDZ PF10506.9 EKE42108.1 - 0.4 10.7 5.8 1.4 9.0 0.2 3.3 3 1 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome TBCC_N PF16752.5 EKE42108.1 - 7.9 7.0 12.1 1.2 9.6 1.7 2.8 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain EF-hand_1 PF00036.32 EKE42110.1 - 2.1e-16 58.1 1.1 0.00012 21.4 0.0 3.7 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EKE42110.1 - 6.8e-12 45.7 2.9 1.8e-06 28.3 0.6 3.3 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EKE42110.1 - 1.8e-11 43.0 0.9 0.00043 20.0 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EKE42110.1 - 6.8e-08 32.2 3.5 0.00045 20.0 0.3 4.2 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 EKE42110.1 - 8.9e-07 28.1 0.7 0.0084 15.6 0.1 3.5 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.7 EKE42110.1 - 0.0014 18.6 0.8 0.2 11.6 0.3 2.8 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Ras PF00071.22 EKE42111.1 - 5.6e-34 117.1 0.6 6.4e-34 116.9 0.6 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42111.1 - 1.1e-16 61.1 0.0 1.7e-16 60.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EKE42111.1 - 1.8e-07 30.9 0.2 3.4e-06 26.8 0.2 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EKE42111.1 - 2.7e-07 30.2 0.1 3.2e-07 30.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE42111.1 - 9.4e-06 25.6 2.0 0.002 18.0 0.5 2.2 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE42111.1 - 6.7e-05 22.9 0.1 0.00015 21.8 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKE42111.1 - 0.00036 20.1 1.6 0.038 13.5 0.5 2.9 2 1 1 3 3 3 2 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EKE42111.1 - 0.00068 19.6 3.5 0.0029 17.6 3.3 2.1 1 1 1 2 2 2 1 C-terminal region of MMR_HSR1 domain DLIC PF05783.11 EKE42111.1 - 0.0037 16.2 0.0 1.1 7.9 0.0 2.3 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) AAA_24 PF13479.6 EKE42111.1 - 0.024 14.4 0.3 0.048 13.4 0.3 1.7 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EKE42111.1 - 0.027 14.4 3.2 0.4 10.5 3.2 2.1 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Cyc-maltodext_C PF10438.9 EKE42111.1 - 0.068 13.3 1.4 0.73 10.0 0.6 2.3 1 1 1 2 2 2 0 Cyclo-malto-dextrinase C-terminal domain DUF1611 PF07755.11 EKE42111.1 - 0.11 11.8 0.2 0.17 11.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain Glyco_hydro_30C PF17189.4 EKE42111.1 - 0.12 12.6 0.3 0.33 11.2 0.3 1.7 1 0 0 1 1 1 0 Glycosyl hydrolase family 30 beta sandwich domain FliS PF02561.14 EKE42111.1 - 0.13 12.5 0.1 1 9.7 0.0 2.1 2 0 0 2 2 2 0 Flagellar protein FliS TLD PF07534.16 EKE42112.1 - 9.4e-08 32.4 2.5 0.00015 22.0 0.1 2.7 2 0 0 2 2 2 2 TLD TTRAP PF14203.6 EKE42112.1 - 0.15 12.1 6.0 1.6 8.8 0.0 4.3 4 1 0 4 4 4 0 Putative tranposon-transfer assisting protein MEIOC PF15189.6 EKE42112.1 - 2.1 7.9 8.3 0.14 11.7 1.7 2.2 1 1 0 2 2 2 0 Meiosis-specific coiled-coil domain-containing protein MEIOC ATG_C PF09333.11 EKE42113.1 - 0.0035 17.6 0.0 0.0084 16.4 0.0 1.6 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain NIF PF03031.18 EKE42114.1 - 8.8e-16 58.0 0.5 4.2e-15 55.9 0.5 2.1 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase DEAD PF00270.29 EKE42116.1 - 1.1e-26 93.6 0.2 3e-26 92.3 0.2 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE42116.1 - 6.1e-23 81.3 3.4 3.3e-22 78.9 0.9 2.9 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE42116.1 - 1.9e-07 31.2 0.1 4.1e-06 26.9 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit MutL PF13941.6 EKE42116.1 - 0.0024 16.5 0.5 0.0037 15.9 0.5 1.2 1 0 0 1 1 1 1 MutL protein AAA_22 PF13401.6 EKE42116.1 - 0.0072 16.6 0.0 0.027 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain SWI2_SNF2 PF18766.1 EKE42116.1 - 0.018 14.7 0.0 0.039 13.6 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase NACHT PF05729.12 EKE42116.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Mito_carr PF00153.27 EKE42118.1 - 7.8e-54 179.6 5.5 1.2e-18 66.8 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein TMEM141 PF15110.6 EKE42118.1 - 0.038 14.5 2.6 3.7 8.2 0.0 2.8 2 1 1 3 3 3 0 TMEM141 protein family PI3Ka PF00613.20 EKE42120.1 - 3.4e-51 173.3 3.5 3.8e-51 173.1 1.9 1.9 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EKE42120.1 - 6e-44 150.7 0.1 3.8e-42 144.8 0.1 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_rbd PF00794.18 EKE42120.1 - 2.6e-13 50.1 0.2 1.8e-12 47.4 0.1 2.5 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain PI3K_C2 PF00792.24 EKE42120.1 - 1.3e-12 47.8 0.0 2.8e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 EKE42120.1 - 0.0048 16.3 0.0 0.0089 15.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) WD40 PF00400.32 EKE42121.1 - 5.5e-24 84.0 1.1 3.1e-06 27.8 0.1 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat BBS2_Mid PF14783.6 EKE42121.1 - 0.00088 19.3 3.8 0.024 14.7 0.1 4.1 3 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region SGL PF08450.12 EKE42121.1 - 0.00092 18.9 0.1 0.0026 17.4 0.0 1.8 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region ANAPC4_WD40 PF12894.7 EKE42121.1 - 0.0035 17.6 0.5 0.07 13.4 0.2 3.2 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain VID27 PF08553.10 EKE42121.1 - 0.004 16.3 1.0 0.0055 15.8 0.1 1.6 2 0 0 2 2 2 1 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 EKE42121.1 - 0.008 14.7 0.1 0.63 8.5 0.0 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain DDE_Tnp_IS66 PF03050.14 EKE42121.1 - 0.078 12.4 1.4 0.12 11.8 1.4 1.2 1 0 0 1 1 1 0 Transposase IS66 family vATP-synt_E PF01991.18 EKE42121.1 - 0.1 12.0 5.4 0.2 11.0 5.4 1.4 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit PQQ PF01011.21 EKE42121.1 - 0.22 11.5 1.6 4.5 7.4 0.1 3.2 3 0 0 3 3 3 0 PQQ enzyme repeat FKBP_C PF00254.28 EKE42122.1 - 3.2e-15 56.2 0.1 7.5e-15 55.0 0.1 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 EKE42122.1 - 3.6e-10 39.2 6.0 7.1e-08 32.0 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EKE42122.1 - 4.6e-10 38.8 4.9 1.1e-06 28.2 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EKE42122.1 - 2.3e-06 27.4 0.0 2.3e-06 27.4 0.0 3.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EKE42122.1 - 5e-05 23.7 0.9 0.0002 21.8 0.1 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EKE42122.1 - 7.2e-05 22.4 0.5 0.0026 17.4 0.1 2.7 2 0 0 2 2 2 1 TPR repeat TPR_14 PF13428.6 EKE42122.1 - 0.00022 21.8 0.2 0.0053 17.5 0.0 3.0 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EKE42122.1 - 0.0015 19.1 0.1 0.0085 16.7 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EKE42122.1 - 0.0015 18.6 0.0 0.0077 16.4 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EKE42122.1 - 0.0025 18.1 1.3 0.61 10.4 0.0 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EKE42122.1 - 0.01 15.8 0.1 7 6.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EKE42122.1 - 0.02 15.3 1.7 0.74 10.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EKE42122.1 - 0.039 14.6 0.1 0.13 12.9 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat RRM_1 PF00076.22 EKE42123.1 - 0.0055 16.5 0.4 0.012 15.4 0.3 1.7 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATG19_autophagy PF12744.7 EKE42123.1 - 0.02 14.1 0.3 0.023 13.9 0.3 1.2 1 0 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding Pkinase PF00069.25 EKE42124.1 - 1.8e-50 171.8 0.4 6.8e-50 169.9 0.4 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42124.1 - 7.1e-21 74.7 0.1 1.4e-19 70.4 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Choline_kinase PF01633.20 EKE42124.1 - 0.0019 17.9 0.5 0.0019 17.9 0.5 1.9 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.22 EKE42124.1 - 0.0081 15.8 0.0 0.0081 15.8 0.0 2.8 3 0 0 3 3 3 1 RIO1 family FcoT PF10862.8 EKE42124.1 - 0.017 14.7 0.1 0.039 13.6 0.1 1.6 1 0 0 1 1 1 0 FcoT-like thioesterase domain Kdo PF06293.14 EKE42124.1 - 0.02 14.3 0.1 0.033 13.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EKE42124.1 - 0.024 14.5 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EKE42124.1 - 0.04 13.2 0.0 0.078 12.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like ABC1 PF03109.16 EKE42124.1 - 0.087 13.0 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 ABC1 family DENN PF02141.21 EKE42127.1 - 8.4e-31 107.4 0.4 1.4e-30 106.6 0.4 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EKE42127.1 - 2e-08 34.8 0.2 9.5e-08 32.7 0.2 2.2 1 0 0 1 1 1 1 uDENN domain LIM PF00412.22 EKE42127.1 - 0.0011 19.2 18.4 0.0039 17.4 18.4 2.0 1 0 0 1 1 1 1 LIM domain AMP-binding PF00501.28 EKE42128.1 - 8.4e-73 245.4 0.0 1.2e-72 244.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EKE42128.1 - 2.8e-43 148.0 0.0 6.7e-43 146.7 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein AMP-binding_C PF13193.6 EKE42128.1 - 7e-15 55.8 0.1 2e-13 51.1 0.1 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Epimerase PF01370.21 EKE42128.1 - 2.3e-13 50.2 0.0 5.1e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EKE42128.1 - 9.4e-11 41.2 0.1 1.5e-10 40.6 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 EKE42128.1 - 2.2e-08 34.3 0.0 4.1e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site RmlD_sub_bind PF04321.17 EKE42128.1 - 3.9e-05 22.9 0.0 8.9e-05 21.7 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EKE42128.1 - 0.00021 20.8 0.6 0.00061 19.3 0.1 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EKE42128.1 - 0.0084 16.0 0.0 0.044 13.7 0.0 2.1 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EKE42128.1 - 0.12 11.9 0.0 0.3 10.6 0.0 1.6 1 0 0 1 1 1 0 NmrA-like family F_actin_bund_C PF18060.1 EKE42129.1 - 9.8e-13 48.0 21.0 9.8e-13 48.0 21.0 2.5 1 1 1 2 2 2 1 F actin bundling C terminal Cast PF10174.9 EKE42129.1 - 0.00017 20.0 20.7 0.00021 19.7 20.7 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone DUF677 PF05055.12 EKE42129.1 - 0.0057 15.6 7.4 0.0057 15.6 7.4 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF677) UPF0184 PF03670.13 EKE42129.1 - 0.066 13.6 4.4 0.099 13.0 1.3 2.7 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) Bacillus_HBL PF05791.11 EKE42129.1 - 0.19 11.5 11.6 0.028 14.3 7.0 1.9 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Borrelia_P83 PF05262.11 EKE42129.1 - 0.39 9.2 26.7 0.52 8.8 26.7 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DFF-C PF09033.10 EKE42129.1 - 2.2 8.2 14.0 0.48 10.3 10.1 1.7 1 1 1 2 2 2 0 DNA Fragmentation factor 45kDa, C terminal domain RhoGEF PF00621.20 EKE42131.1 - 1e-34 120.4 3.8 1e-34 120.4 3.8 2.2 2 1 0 2 2 2 1 RhoGEF domain zf-piccolo PF05715.13 EKE42131.1 - 0.0037 17.4 9.1 0.0037 17.4 9.1 2.3 2 1 0 2 2 2 1 Piccolo Zn-finger Fer4_22 PF17179.4 EKE42131.1 - 0.033 15.0 6.2 0.099 13.5 6.2 1.8 1 0 0 1 1 1 0 4Fe-4S dicluster domain FYVE PF01363.21 EKE42131.1 - 0.45 10.7 8.6 1.3 9.2 8.6 1.8 1 0 0 1 1 1 0 FYVE zinc finger SH3_9 PF14604.6 EKE42132.1 - 1.1e-13 50.8 0.7 2.3e-13 49.7 0.7 1.5 1 0 0 1 1 1 1 Variant SH3 domain BAR PF03114.18 EKE42132.1 - 4.3e-13 49.5 11.9 6.7e-13 48.8 11.8 1.4 1 1 0 1 1 1 1 BAR domain SH3_2 PF07653.17 EKE42132.1 - 1.3e-12 47.2 0.1 2.5e-12 46.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EKE42132.1 - 2.6e-12 46.1 0.5 4.9e-12 45.3 0.5 1.5 1 0 0 1 1 1 1 SH3 domain Peptidase_C48 PF02902.19 EKE42133.1 - 2.9e-21 76.3 0.0 5.9e-21 75.3 0.0 1.5 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain OST_P2 PF18235.1 EKE42133.1 - 0.017 15.1 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 Oligosaccharyltransferase Peripheral 2 domain Glyco_hydro_25 PF01183.20 EKE42134.1 - 1.5e-06 28.5 0.8 1.5e-06 28.5 0.8 2.8 3 1 0 3 3 3 1 Glycosyl hydrolases family 25 MORN_2 PF07661.13 EKE42134.1 - 0.024 14.8 1.4 15 6.2 0.1 3.3 3 0 0 3 3 3 0 MORN repeat variant Tai4 PF16695.5 EKE42134.1 - 0.04 14.4 0.7 0.51 10.9 0.9 2.8 2 0 0 2 2 2 0 Type VI secretion system (T6SS), amidase immunity protein Imm40 PF15569.6 EKE42134.1 - 0.3 11.2 5.7 0.99 9.6 0.1 3.2 3 0 0 3 3 3 0 Immunity protein 40 Med13_C PF06333.12 EKE42134.1 - 0.84 8.8 12.5 1.5 8.0 12.5 1.4 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain RabGAP-TBC PF00566.18 EKE42135.1 - 4e-22 79.0 0.5 5.7e-22 78.4 0.5 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PIG-L PF02585.17 EKE42136.1 - 9.8e-16 58.6 0.2 6e-14 52.8 0.2 2.3 1 1 0 1 1 1 1 GlcNAc-PI de-N-acetylase Glyco_transf_24 PF18404.1 EKE42137.1 - 4.3e-115 383.7 7.7 4.3e-115 383.7 7.7 2.7 3 0 0 3 3 3 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EKE42137.1 - 4e-15 56.4 6.4 4e-15 56.4 6.4 2.5 2 0 0 2 2 2 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 EKE42137.1 - 3.7e-09 36.5 2.5 3.7e-09 36.5 2.5 2.7 2 0 0 2 2 2 1 Glycosyl transferase family 8 Thioredoxin_13 PF18401.1 EKE42137.1 - 2.4e-06 27.5 8.2 6e-06 26.2 4.8 3.0 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EKE42137.1 - 0.00043 20.2 0.0 0.0017 18.2 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain DUF5412 PF17428.2 EKE42137.1 - 0.039 13.8 7.4 0.35 10.7 3.3 3.8 3 1 0 3 3 3 0 Family of unknown function (DUF5412) DUF2110 PF09883.9 EKE42137.1 - 0.28 10.7 3.7 0.24 11.0 0.6 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2110) His_Phos_2 PF00328.22 EKE42141.1 - 6.7e-25 88.2 4.3 1.4e-24 87.2 0.9 2.4 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) DUF1664 PF07889.12 EKE42142.1 - 0.011 15.7 22.8 0.13 12.3 2.2 3.5 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 EKE42142.1 - 0.076 13.0 27.3 0.17 11.9 11.7 2.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LPP PF04728.13 EKE42142.1 - 0.096 13.1 4.7 3.7 8.0 1.7 3.1 2 1 1 3 3 3 0 Lipoprotein leucine-zipper ADIP PF11559.8 EKE42142.1 - 0.39 10.8 29.2 3 7.9 18.5 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DASH_Dam1 PF08653.10 EKE42142.1 - 0.7 9.7 9.2 0.6 9.9 0.3 3.2 3 0 0 3 3 3 0 DASH complex subunit Dam1 SPG48 PF14764.6 EKE42142.1 - 0.93 10.0 5.5 0.67 10.4 0.3 2.9 3 0 0 3 3 3 0 AP-5 complex subunit, vesicle trafficking NPV_P10 PF05531.12 EKE42142.1 - 1.9 9.0 11.4 6.7 7.3 0.8 2.7 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TFR_dimer PF04253.15 EKE42142.1 - 2.8 8.0 9.0 33 4.6 3.0 3.0 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain CHASE3 PF05227.13 EKE42142.1 - 5.1 7.0 9.8 6.4 6.7 1.0 2.8 1 1 2 3 3 3 0 CHASE3 domain Spc7 PF08317.11 EKE42142.1 - 5.7 5.7 31.9 0.88 8.4 19.7 2.5 2 1 1 3 3 3 0 Spc7 kinetochore protein Cupin_4 PF08007.12 EKE42142.1 - 6.7 6.1 8.6 3.5 7.0 0.1 3.0 2 1 1 3 3 3 0 Cupin superfamily protein JIP_LZII PF16471.5 EKE42142.1 - 8 6.7 23.0 3.7 7.8 0.9 3.6 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II ZapB PF06005.12 EKE42142.1 - 9.4 6.8 24.5 33 5.0 13.6 3.3 1 1 1 2 2 2 0 Cell division protein ZapB SlyX PF04102.12 EKE42142.1 - 9.6 6.9 12.0 1.6 9.4 0.4 3.3 2 1 1 3 3 3 0 SlyX RasGAP PF00616.19 EKE42143.1 - 1.1e-30 106.9 10.6 2.4e-23 83.0 2.6 2.8 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 EKE42143.1 - 1.9e-06 28.1 0.2 6.1e-06 26.4 0.2 1.9 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Myosin_TH1 PF06017.13 EKE42143.1 - 3.9e-05 23.4 0.9 9.5e-05 22.2 0.1 2.1 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding RnlB_antitoxin PF15933.5 EKE42143.1 - 0.042 14.2 1.4 0.17 12.2 1.4 2.1 1 0 0 1 1 1 0 Antitoxin to bacterial toxin RNase LS or RnlA Vps51 PF08700.11 EKE42144.1 - 0.073 13.2 4.7 0.17 12.0 4.6 1.7 1 1 0 1 1 1 0 Vps51/Vps67 DUF4407 PF14362.6 EKE42144.1 - 0.22 10.8 3.9 0.27 10.6 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HHH_9 PF17674.1 EKE42144.1 - 1.1 10.2 4.4 4.9 8.1 4.4 2.1 1 1 0 1 1 1 0 HHH domain FAM76 PF16046.5 EKE42144.1 - 5.4 6.3 13.0 9 5.5 13.0 1.5 1 1 0 1 1 1 0 FAM76 protein SapB_2 PF03489.17 EKE42145.1 - 7.5e-07 29.1 0.9 7.5e-07 29.1 0.9 1.9 2 0 0 2 2 2 1 Saposin-like type B, region 2 SapB_1 PF05184.15 EKE42145.1 - 0.0082 16.1 0.5 0.067 13.2 0.0 2.3 2 1 1 3 3 3 1 Saposin-like type B, region 1 TRAM_LAG1_CLN8 PF03798.16 EKE42146.1 - 2.3e-30 105.8 18.4 3.6e-30 105.2 18.4 1.3 1 0 0 1 1 1 1 TLC domain WD40 PF00400.32 EKE42147.1 - 9.2e-05 23.2 0.8 9.2 7.3 0.1 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat CPBP PF02517.16 EKE42149.1 - 2.1e-17 63.3 4.7 2.1e-17 63.3 4.7 2.7 1 1 1 2 2 2 1 CPBP intramembrane metalloprotease Yip1 PF04893.17 EKE42149.1 - 0.32 10.7 24.7 1.1e+03 -0.8 24.7 2.7 1 1 0 1 1 1 0 Yip1 domain 7TMR-DISM_7TM PF07695.11 EKE42149.1 - 0.56 10.1 33.1 4.1 7.2 14.5 2.1 1 1 1 2 2 2 0 7TM diverse intracellular signalling FSAP_sig_propep PF03032.15 EKE42149.1 - 0.57 10.3 1.4 1.2 9.3 0.0 2.0 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide DUF543 PF04418.12 EKE42149.1 - 3.2 7.8 4.9 4.3 7.4 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF543) Rad60-SLD PF11976.8 EKE42150.1 - 1.3e-17 63.4 2.7 2.4e-09 36.9 0.2 2.5 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EKE42150.1 - 1.3e-14 53.7 1.1 1.2e-06 28.2 0.1 2.4 2 1 1 3 3 3 2 Ubiquitin family Ubiquitin_4 PF18036.1 EKE42150.1 - 0.01 15.9 0.8 0.11 12.5 0.2 2.4 1 1 1 2 2 2 0 Ubiquitin-like domain Ras PF00071.22 EKE42151.1 - 6.6e-46 155.9 1.7 7.9e-46 155.6 1.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42151.1 - 1.2e-34 119.1 0.3 1.7e-34 118.6 0.3 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42151.1 - 3.4e-14 52.7 0.5 4.1e-14 52.4 0.5 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE42151.1 - 4.8e-08 32.6 0.6 5.7e-08 32.4 0.6 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE42151.1 - 1.8e-05 24.8 0.0 3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE42151.1 - 2.9e-05 23.7 0.1 0.00039 20.0 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE42151.1 - 0.00083 19.3 0.8 0.3 11.0 0.1 2.1 1 1 1 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 EKE42151.1 - 0.0055 16.5 0.2 0.11 12.2 0.2 2.3 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 EKE42151.1 - 0.0059 16.0 0.0 0.013 14.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial TniB protein SRPRB PF09439.10 EKE42151.1 - 0.012 15.1 0.1 0.017 14.5 0.1 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EKE42151.1 - 0.023 14.4 0.2 0.094 12.5 0.2 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EKE42151.1 - 0.023 14.2 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 EKE42151.1 - 0.028 14.8 0.0 0.035 14.5 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 EKE42151.1 - 0.048 12.8 4.0 0.19 10.8 4.0 2.1 1 1 0 1 1 1 0 G-protein alpha subunit MMR_HSR1_Xtn PF16897.5 EKE42151.1 - 0.064 13.3 0.3 0.11 12.5 0.3 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 EKE42151.1 - 0.075 13.1 0.1 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 Dynamin family CPT PF07931.12 EKE42151.1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein RP-C_C PF11800.8 EKE42153.1 - 9.7 6.2 9.0 18 5.3 9.0 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Spt5-NGN PF03439.13 EKE42154.1 - 3.9e-15 55.5 0.1 9.9e-15 54.2 0.1 1.8 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 EKE42154.1 - 1.5e-12 47.0 21.2 0.0022 17.9 0.6 5.8 6 0 0 6 6 6 4 KOW motif DUF3912 PF13051.6 EKE42154.1 - 0.011 16.0 9.8 0.23 11.7 0.2 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3912) SH3_15 PF18346.1 EKE42154.1 - 0.023 15.0 0.6 5 7.5 0.0 3.7 3 1 0 3 3 3 0 Mind bomb SH3 repeat domain Protocadherin PF08374.11 EKE42154.1 - 0.043 13.8 6.8 0.78 9.7 6.8 2.6 1 1 0 1 1 1 0 Protocadherin FTR_C PF02741.15 EKE42154.1 - 0.061 13.4 0.0 14 5.6 0.0 2.4 2 0 0 2 2 2 0 FTR, proximal lobe ThiS-like PF14453.6 EKE42154.1 - 0.085 12.9 1.7 0.6 10.2 0.1 3.1 3 0 0 3 3 3 0 ThiS-like ubiquitin Peptidase_S24 PF00717.23 EKE42154.1 - 1.2 9.1 5.9 22 5.1 0.1 3.3 3 0 0 3 3 3 0 Peptidase S24-like Rep_fac-A_3 PF08661.11 EKE42155.1 - 0.0054 17.1 0.0 0.0076 16.6 0.0 1.3 1 1 0 1 1 1 1 Replication factor A protein 3 Isy1 PF06246.12 EKE42156.1 - 1.3e-40 139.6 10.3 1.6e-40 139.3 10.3 1.1 1 0 0 1 1 1 1 Isy1-like splicing family Glyco_hydro_108 PF05838.12 EKE42156.1 - 0.12 12.9 0.5 0.49 10.9 0.2 1.9 2 0 0 2 2 2 0 Glycosyl hydrolase 108 PQ-loop PF04193.14 EKE42157.1 - 2e-17 62.7 12.9 1.3e-10 40.9 1.2 3.8 4 0 0 4 4 4 2 PQ loop repeat FAM163 PF15069.6 EKE42157.1 - 0.054 14.0 0.9 0.13 12.7 0.9 1.7 1 0 0 1 1 1 0 FAM163 family MgsA_C PF12002.8 EKE42158.1 - 4e-28 98.5 0.0 6e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EKE42158.1 - 2.7e-23 82.1 0.3 5.7e-23 81.1 0.3 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EKE42158.1 - 7.3e-15 55.6 0.9 2.9e-14 53.6 0.2 2.3 2 1 1 3 3 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EKE42158.1 - 5.7e-12 45.7 0.0 1.1e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EKE42158.1 - 6.2e-07 29.5 0.0 4.2e-06 26.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EKE42158.1 - 1.5e-06 28.3 0.6 5e-06 26.6 0.2 2.0 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 EKE42158.1 - 9.5e-06 26.0 0.1 0.014 15.7 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_22 PF13401.6 EKE42158.1 - 1.7e-05 25.1 1.7 0.002 18.4 1.7 3.0 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EKE42158.1 - 1.7e-05 24.6 0.0 0.00031 20.5 0.0 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.6 EKE42158.1 - 0.0001 22.9 0.1 0.00028 21.4 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EKE42158.1 - 0.00017 22.0 0.0 0.04 14.3 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 EKE42158.1 - 0.00021 21.1 0.0 0.00033 20.5 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase G-alpha PF00503.20 EKE42158.1 - 0.00044 19.5 0.2 0.0005 19.3 0.2 1.3 1 0 0 1 1 1 1 G-protein alpha subunit RNA_helicase PF00910.22 EKE42158.1 - 0.00046 20.5 0.0 0.0014 18.9 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_2 PF07724.14 EKE42158.1 - 0.00072 19.7 0.7 0.0014 18.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ABC_tran PF00005.27 EKE42158.1 - 0.00085 19.9 0.1 0.0022 18.5 0.0 1.7 1 1 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 EKE42158.1 - 0.0011 18.8 0.0 0.0062 16.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EKE42158.1 - 0.0014 19.1 0.0 0.0049 17.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EKE42158.1 - 0.0014 18.0 0.0 0.028 13.8 0.0 2.1 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI Thymidylate_kin PF02223.17 EKE42158.1 - 0.0015 18.3 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 Thymidylate kinase AAA_24 PF13479.6 EKE42158.1 - 0.0028 17.4 0.1 0.0056 16.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EKE42158.1 - 0.0039 17.1 0.1 0.0089 16.0 0.1 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain ATP_bind_1 PF03029.17 EKE42158.1 - 0.0077 16.0 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 EKE42158.1 - 0.022 14.7 0.2 0.29 11.0 0.0 2.4 1 1 1 2 2 2 0 NTPase AAA_3 PF07726.11 EKE42158.1 - 0.03 14.2 0.0 0.099 12.5 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EKE42158.1 - 0.037 14.2 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain ADK PF00406.22 EKE42158.1 - 0.042 14.0 0.1 0.17 12.0 0.0 2.1 2 0 0 2 2 1 0 Adenylate kinase AAA_25 PF13481.6 EKE42158.1 - 0.047 13.3 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EKE42158.1 - 0.065 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 EKE42158.1 - 0.067 13.4 0.0 0.25 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EKE42158.1 - 0.071 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_pol_Rpb2_6 PF00562.28 EKE42160.1 - 1.8e-126 422.3 0.0 2.7e-126 421.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EKE42160.1 - 1e-51 175.4 1.7 2e-51 174.4 0.7 1.9 2 0 0 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EKE42160.1 - 1.4e-31 108.7 0.5 4.7e-31 107.0 0.5 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EKE42160.1 - 4.8e-23 81.2 0.3 1.4e-22 79.8 0.3 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.14 EKE42160.1 - 2.3e-21 76.3 2.3 2.3e-21 76.3 2.3 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 EKE42160.1 - 1.2e-19 70.3 0.0 1.1e-18 67.1 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EKE42160.1 - 6.4e-08 33.0 3.8 2.3e-07 31.3 3.8 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 V_ATPase_I PF01496.19 EKE42161.1 - 3.3e-239 796.0 14.5 1.9e-238 793.5 14.5 2.1 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family Nup35_RRM PF05172.13 EKE42161.1 - 0.089 12.8 0.4 2.2 8.3 0.1 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif PP2C PF00481.21 EKE42163.1 - 6.1e-57 193.2 0.0 7.6e-57 192.9 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE42163.1 - 0.003 17.5 0.0 0.12 12.3 0.0 2.2 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EKE42163.1 - 0.035 13.8 0.0 0.097 12.3 0.0 1.6 1 1 0 1 1 1 0 Protein phosphatase 2C Ras PF00071.22 EKE42164.1 - 5.4e-62 208.2 0.6 6.5e-62 207.9 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42164.1 - 1.9e-34 118.5 0.1 3.3e-34 117.7 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42164.1 - 2.7e-16 59.5 0.1 3.5e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE42164.1 - 1.7e-07 31.3 0.0 2.9e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE42164.1 - 6e-06 26.3 0.1 0.047 13.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EKE42164.1 - 0.00067 19.3 0.1 0.0012 18.4 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EKE42164.1 - 0.0012 18.3 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EKE42164.1 - 0.0012 19.2 0.0 0.0018 18.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 EKE42164.1 - 0.0041 17.4 0.0 1.1 9.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain SRPRB PF09439.10 EKE42164.1 - 0.0043 16.5 0.0 0.006 16.0 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 EKE42164.1 - 0.0045 17.5 0.1 0.01 16.3 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 EKE42164.1 - 0.0061 16.8 0.0 0.015 15.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EKE42164.1 - 0.015 15.1 0.1 0.029 14.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EKE42164.1 - 0.016 15.1 0.2 0.026 14.4 0.2 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EKE42164.1 - 0.028 14.0 0.0 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 EKE42164.1 - 0.042 13.6 0.0 0.37 10.5 0.0 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 EKE42164.1 - 0.075 13.0 0.0 0.51 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NPHI_C PF08469.10 EKE42164.1 - 0.099 12.6 0.6 0.16 11.9 0.3 1.4 2 0 0 2 2 1 0 Nucleoside triphosphatase I C-terminal RNA_pol_Rpb4 PF03874.16 EKE42165.1 - 1.7e-08 34.8 0.4 2e-07 31.3 0.4 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb4 DUF5584 PF17822.1 EKE42165.1 - 0.017 14.6 0.1 0.023 14.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5584) Styelin PF17562.2 EKE42165.1 - 0.24 11.8 1.5 0.5 10.8 1.5 1.5 1 0 0 1 1 1 0 Styelin Pkinase_Tyr PF07714.17 EKE42166.1 - 3.8e-39 134.5 0.0 6.4e-39 133.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE42166.1 - 1.4e-29 103.3 0.0 4.8e-29 101.5 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain LRR_8 PF13855.6 EKE42166.1 - 6.1e-13 48.3 33.2 4.7e-07 29.5 3.0 5.4 4 2 1 6 6 6 4 Leucine rich repeat Myotub-related PF06602.14 EKE42166.1 - 3.9e-12 45.8 9.5 1.5e-11 43.9 9.5 1.9 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain LRR_4 PF12799.7 EKE42166.1 - 3.8e-05 24.0 53.2 0.00065 20.1 5.6 7.5 4 2 4 8 8 8 4 Leucine Rich repeats (2 copies) RhoGAP PF00620.27 EKE42166.1 - 0.005 16.7 2.1 0.054 13.3 0.0 3.2 1 1 2 3 3 3 1 RhoGAP domain Pou PF00157.17 EKE42166.1 - 0.13 12.3 0.0 0.51 10.3 0.0 2.1 1 0 0 1 1 1 0 Pou domain - N-terminal to homeobox domain LRR_5 PF13306.6 EKE42167.1 - 4.1e-46 156.1 29.3 1.2e-27 96.4 12.4 3.5 3 1 1 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE42167.1 - 5.9e-07 29.1 1.9 1.2 9.0 0.2 5.6 3 2 3 6 6 6 3 Leucine rich repeat Eclosion PF04736.12 EKE42167.1 - 0.0019 17.8 0.9 0.01 15.5 0.9 2.2 1 1 0 1 1 1 1 Eclosion hormone ADH_zinc_N PF00107.26 EKE42168.1 - 1.9e-16 60.2 0.0 3e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EKE42168.1 - 1.4e-14 53.9 0.1 1.4e-14 53.9 0.1 1.8 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 EKE42168.1 - 2e-05 24.2 0.0 3.3e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EKE42168.1 - 0.015 16.4 0.0 0.026 15.6 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase ThiF PF00899.21 EKE42169.1 - 0.04 13.3 0.0 0.04 13.3 0.0 1.1 1 0 0 1 1 1 0 ThiF family ThiF PF00899.21 EKE42170.1 - 0.00019 20.9 0.0 0.00023 20.6 0.0 1.1 1 0 0 1 1 1 1 ThiF family Hexapep PF00132.24 EKE42171.1 - 1.7e-17 62.4 8.8 1e-09 37.7 0.5 4.5 3 1 2 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EKE42171.1 - 4.6e-10 39.1 8.4 0.00016 21.4 0.8 3.5 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EKE42171.1 - 0.00092 18.3 1.7 0.002 17.1 1.8 1.6 1 1 0 1 1 1 1 L-fucokinase DUF4954 PF16314.5 EKE42171.1 - 0.088 10.9 2.5 0.12 10.5 2.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) MalM PF07148.12 EKE42171.1 - 0.089 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Maltose operon periplasmic protein precursor (MalM) Drf_FH3 PF06367.16 EKE42172.1 - 0.011 15.3 0.0 0.027 14.1 0.0 1.6 1 1 0 1 1 1 0 Diaphanous FH3 Domain Pou PF00157.17 EKE42172.1 - 0.042 13.8 0.0 0.086 12.8 0.0 1.5 2 0 0 2 2 2 0 Pou domain - N-terminal to homeobox domain Glyco_hydro_20 PF00728.22 EKE42173.1 - 7.7e-83 278.8 0.3 1.1e-82 278.3 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EKE42173.1 - 6e-12 46.4 1.5 9.2e-12 45.8 0.3 2.0 2 1 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EKE42173.1 - 7.4e-06 26.8 0.0 2e-05 25.3 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 LpqV PF17301.2 EKE42173.1 - 0.12 12.7 0.1 0.24 11.7 0.1 1.4 1 0 0 1 1 1 0 Putative lipoprotein LpqV DUF5496 PF17600.2 EKE42173.1 - 0.12 12.4 0.0 0.36 10.9 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5496) RasGAP PF00616.19 EKE42174.1 - 0.0021 17.8 13.0 0.0028 17.4 1.6 2.5 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase JAKMIP_CC3 PF16034.5 EKE42174.1 - 0.07 13.1 1.7 0.12 12.3 1.7 1.3 1 0 0 1 1 1 0 JAKMIP CC3 domain DUF5321 PF17254.2 EKE42176.1 - 0.0039 16.7 1.0 0.0064 15.9 1.0 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5321) Dynein_AAA_lid PF17852.1 EKE42176.1 - 0.0045 17.1 1.8 0.0099 16.0 0.2 2.0 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain DUF2362 PF10154.9 EKE42176.1 - 0.013 14.5 1.2 0.019 13.9 1.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) DUF655 PF04919.12 EKE42176.1 - 0.015 15.3 1.7 0.021 14.8 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF655) COMMD1_N PF17221.3 EKE42176.1 - 0.045 14.1 0.1 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 COMMD1 N-terminal domain Raco_middle PF17651.1 EKE42176.1 - 0.2 11.3 0.8 0.28 10.9 0.8 1.2 1 0 0 1 1 1 0 RACo middle region TrkH PF02386.16 EKE42177.1 - 6.3e-40 137.1 34.8 2.4e-37 128.6 25.6 2.4 2 1 0 2 2 2 2 Cation transport protein Hydrolase_3 PF08282.12 EKE42178.1 - 2.7e-57 194.4 7.1 3e-57 194.3 7.1 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EKE42178.1 - 6e-12 45.6 0.0 7.9e-05 22.3 0.0 2.4 2 1 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EKE42178.1 - 1.2e-07 32.2 6.0 2.3e-05 24.8 6.0 3.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EKE42178.1 - 6.1e-07 30.0 0.3 0.029 14.8 0.0 3.3 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 EKE42178.1 - 1.1e-05 24.7 0.2 0.0052 15.9 0.0 2.1 2 0 0 2 2 2 2 Trehalose-phosphatase E3_binding PF02817.17 EKE42178.1 - 0.034 14.5 0.2 0.23 11.8 0.0 2.4 2 0 0 2 2 2 0 e3 binding domain DUF4476 PF14771.6 EKE42178.1 - 0.035 14.4 0.2 0.23 11.8 0.1 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4476) UPF0086 PF01868.16 EKE42178.1 - 0.041 13.8 0.3 0.11 12.4 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function UPF0086 Vps35 PF03635.17 EKE42179.1 - 1.6e-154 516.3 24.5 2e-154 515.9 24.5 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 RPM2 PF08579.11 EKE42180.1 - 0.065 13.6 2.2 6.8 7.1 0.3 2.9 2 2 0 2 2 2 0 Mitochondrial ribonuclease P subunit (RPM2) Prefoldin_2 PF01920.20 EKE42181.1 - 3.6e-11 43.0 15.1 4.3e-11 42.7 15.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit FlaC_arch PF05377.11 EKE42181.1 - 0.0048 17.3 7.7 0.26 11.7 0.1 2.9 2 1 1 3 3 3 2 Flagella accessory protein C (FlaC) Prefoldin PF02996.17 EKE42181.1 - 0.051 13.5 10.5 0.094 12.6 10.5 1.5 1 1 0 1 1 1 0 Prefoldin subunit Snapin_Pallidin PF14712.6 EKE42181.1 - 0.62 10.5 9.7 1.5 9.3 0.8 2.2 2 0 0 2 2 2 0 Snapin/Pallidin DivIC PF04977.15 EKE42181.1 - 1.2 9.0 11.9 1.5 8.7 3.5 2.3 2 0 0 2 2 2 0 Septum formation initiator XhlA PF10779.9 EKE42181.1 - 2.9 8.2 6.6 0.34 11.2 0.7 2.2 2 1 1 3 3 3 0 Haemolysin XhlA Ribosomal_S17_N PF16205.5 EKE42182.1 - 2.8e-26 91.7 0.3 2.8e-26 91.7 0.3 1.6 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EKE42182.1 - 2.1e-25 88.6 2.0 3.6e-25 87.8 2.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Mo-nitro_C PF06967.11 EKE42182.1 - 0.075 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Mo-dependent nitrogenase C-terminus TPR_MLP1_2 PF07926.12 EKE42183.1 - 0.37 10.8 24.6 0.72 9.9 16.6 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein GLE1 PF07817.13 EKE42183.1 - 0.6 9.3 13.0 0.066 12.4 6.7 2.0 1 1 1 2 2 2 0 GLE1-like protein Cbl_N2 PF02761.14 EKE42183.1 - 2 9.2 8.7 0.76 10.5 1.1 2.9 1 1 2 3 3 3 0 CBL proto-oncogene N-terminus, EF hand-like domain Tup_N PF08581.10 EKE42183.1 - 3.6 8.0 28.3 15 5.9 11.3 3.2 1 1 1 2 2 2 0 Tup N-terminal GAGA_bind PF06217.12 EKE42183.1 - 8.7 6.5 11.1 9.9 6.3 11.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family ATPgrasp_Ter PF15632.6 EKE42185.1 - 0.011 15.5 1.6 0.013 15.2 0.9 1.6 1 1 1 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_S46 PF10459.9 EKE42185.1 - 0.051 12.2 8.9 0.058 12.0 8.9 1.0 1 0 0 1 1 1 0 Peptidase S46 DUF349 PF03993.12 EKE42185.1 - 0.34 11.2 0.1 0.34 11.2 0.1 2.7 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) AAA_23 PF13476.6 EKE42185.1 - 0.36 11.3 17.4 0.53 10.8 17.4 1.3 1 0 0 1 1 1 0 AAA domain hDGE_amylase PF14701.6 EKE42185.1 - 0.53 9.3 9.9 0.67 9.0 9.9 1.0 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain MutS_III PF05192.18 EKE42185.1 - 0.85 9.8 7.9 1.2 9.3 7.9 1.2 1 0 0 1 1 1 0 MutS domain III zf-C4pol PF14260.6 EKE42185.1 - 1.4 9.5 3.8 2 9.0 2.1 2.3 2 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta DUF1053 PF06327.14 EKE42185.1 - 2.3 8.8 7.6 0.4 11.3 3.0 1.9 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1053) ABC_tran_Xtn PF12848.7 EKE42185.1 - 4.7 7.3 15.3 2.8 8.0 10.5 2.2 2 0 0 2 2 2 0 ABC transporter Exonuc_VII_L PF02601.15 EKE42185.1 - 5.5 6.5 13.4 7.1 6.1 13.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit YgaB PF14182.6 EKE42185.1 - 8.9 6.8 17.0 1 9.8 9.0 2.7 2 1 0 2 2 2 0 YgaB-like protein NEMO PF11577.8 EKE42186.1 - 0.28 11.2 3.8 2.6 8.1 1.1 2.4 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO ECSCR PF15820.5 EKE42187.1 - 0.087 12.7 0.1 0.19 11.6 0.1 1.6 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF4131 PF13567.6 EKE42187.1 - 7.4 6.2 8.0 1.9 8.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Actin PF00022.19 EKE42189.1 - 3.8e-69 233.3 0.0 3.5e-68 230.1 0.0 2.1 1 1 0 1 1 1 1 Actin LRR_5 PF13306.6 EKE42190.1 - 1.4e-156 513.3 121.9 4.6e-34 117.1 10.3 7.0 1 1 6 7 7 7 7 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE42190.1 - 7.5e-32 108.9 39.1 0.00011 21.9 0.2 12.8 5 5 9 14 14 14 10 Leucine rich repeat Fimbrial_PilY2 PF14481.6 EKE42190.1 - 0.0087 15.7 0.1 15 5.3 0.0 4.9 5 2 1 6 6 6 1 Type 4 fimbrial biogenesis protein PilY2 ABC2_membrane_6 PF06182.11 EKE42192.1 - 0.008 16.0 3.3 0.011 15.5 3.3 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein Actin PF00022.19 EKE42193.1 - 3.2e-69 233.5 0.0 1.9e-68 231.0 0.0 1.8 1 1 0 1 1 1 1 Actin Exog_C PF18026.1 EKE42194.1 - 0.097 12.7 0.2 0.097 12.7 0.2 2.1 1 1 1 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain Uso1_p115_C PF04871.13 EKE42195.1 - 0.024 15.0 7.9 0.027 14.9 7.9 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Shugoshin_N PF07558.11 EKE42195.1 - 0.05 13.5 0.9 0.05 13.5 0.9 1.6 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DUF16 PF01519.16 EKE42195.1 - 0.06 13.8 4.8 0.075 13.5 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 SAWADEE PF16719.5 EKE42195.1 - 0.067 13.2 0.4 0.078 13.0 0.4 1.0 1 0 0 1 1 1 0 SAWADEE domain Rootletin PF15035.6 EKE42195.1 - 0.11 12.5 6.3 0.11 12.5 6.3 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion THOC7 PF05615.13 EKE42195.1 - 0.12 12.6 8.2 0.13 12.6 8.2 1.0 1 0 0 1 1 1 0 Tho complex subunit 7 Muted PF14942.6 EKE42195.1 - 0.27 11.5 7.4 0.32 11.3 7.4 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein APG6_N PF17675.1 EKE42195.1 - 0.29 11.7 8.8 0.47 11.0 8.8 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region FKBP_C PF00254.28 EKE42196.1 - 1.5e-26 92.6 0.0 2.1e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PB1 PF00564.24 EKE42197.1 - 2.7e-09 36.8 0.8 6.5e-09 35.6 0.8 1.6 1 0 0 1 1 1 1 PB1 domain Varsurf_PPLC PF03490.13 EKE42198.1 - 0.0051 16.7 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Variant-surface-glycoprotein phospholipase C IF4E PF01652.18 EKE42199.1 - 4.4e-12 46.1 0.2 1.5e-11 44.4 0.2 1.9 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E HSP90 PF00183.18 EKE42200.1 - 2e-234 779.3 37.3 3e-234 778.7 37.3 1.2 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EKE42200.1 - 1.3e-13 51.4 0.1 3.1e-13 50.2 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EKE42200.1 - 2.8e-11 43.4 0.1 2.8e-11 43.4 0.1 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 EKE42200.1 - 0.012 15.6 0.2 0.25 11.3 0.0 2.4 2 0 0 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN SARAF PF06682.12 EKE42200.1 - 0.44 10.1 2.5 0.83 9.2 2.5 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4578 PF15147.6 EKE42200.1 - 4.1 8.3 6.2 0.85 10.5 1.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) Presenilin PF01080.17 EKE42200.1 - 4.2 6.0 10.0 4.1 6.1 7.7 1.8 2 0 0 2 2 2 0 Presenilin RXT2_N PF08595.11 EKE42200.1 - 7 6.7 16.6 7.2 6.6 9.6 2.9 2 0 0 2 2 2 0 RXT2-like, N-terminal Xpo1 PF08389.12 EKE42201.1 - 7.6e-07 29.3 18.6 3.6e-05 23.9 4.6 5.9 5 3 1 6 6 6 2 Exportin 1-like protein DUF5413 PF17434.2 EKE42201.1 - 0.052 13.9 0.0 0.17 12.2 0.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5413) ABC2_membrane PF01061.24 EKE42202.1 - 1.9e-41 141.8 23.4 1.9e-41 141.8 23.4 1.7 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EKE42202.1 - 7.3e-27 94.5 0.3 1.2e-26 93.8 0.3 1.4 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EKE42202.1 - 0.00085 19.3 0.2 0.0019 18.1 0.2 1.6 1 1 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 EKE42202.1 - 0.0012 18.8 0.4 0.11 12.3 0.3 2.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKE42202.1 - 0.0025 17.5 0.6 0.0052 16.5 0.6 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EKE42202.1 - 0.025 14.1 0.9 0.036 13.7 0.1 1.6 2 0 0 2 2 2 0 AAA domain PDR_CDR PF06422.12 EKE42202.1 - 0.082 12.8 0.4 0.49 10.3 0.1 2.5 2 0 0 2 2 2 0 CDR ABC transporter AAA_28 PF13521.6 EKE42202.1 - 0.14 12.4 0.2 0.36 11.1 0.2 1.8 1 1 0 1 1 1 0 AAA domain Insulin_TMD PF17870.1 EKE42202.1 - 7.9 6.6 8.2 55 3.9 0.1 2.8 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment DUF2816 PF10992.8 EKE42203.1 - 0.093 12.6 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2816) Synaptobrevin PF00957.21 EKE42204.1 - 2.5e-15 56.1 4.4 2.9e-15 55.8 4.4 1.1 1 0 0 1 1 1 1 Synaptobrevin DUF2970 PF11174.8 EKE42204.1 - 0.072 13.0 4.2 0.11 12.4 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2970) TMEM52 PF14979.6 EKE42204.1 - 7.4 6.5 6.0 8.4 6.3 5.8 1.3 1 1 0 1 1 1 0 Transmembrane 52 MMR_HSR1 PF01926.23 EKE42205.1 - 2.2e-16 59.9 0.3 9.2e-14 51.5 0.0 2.9 3 1 0 3 3 3 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE42205.1 - 9.4e-09 35.4 1.2 9.8e-06 25.6 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase FeoB_N PF02421.18 EKE42205.1 - 3.9e-08 33.0 0.7 1.2e-07 31.4 0.1 2.2 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EKE42205.1 - 0.0076 16.3 0.3 0.0076 16.3 0.3 3.6 3 1 1 4 4 4 1 Dynamin family GTP_EFTU PF00009.27 EKE42205.1 - 0.013 15.1 1.4 1.4 8.4 0.1 3.5 3 1 1 4 4 4 0 Elongation factor Tu GTP binding domain Roc PF08477.13 EKE42205.1 - 0.018 15.2 0.2 0.2 11.8 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EKE42205.1 - 0.13 12.6 0.0 2.2 8.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Helicase_C PF00271.31 EKE42207.1 - 2e-12 47.4 0.3 9.3e-12 45.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EKE42207.1 - 1.2e-07 31.7 0.4 2.2e-07 30.8 0.4 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EKE42207.1 - 3.3e-07 30.7 0.1 1.1e-06 28.9 0.1 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EKE42207.1 - 1.7e-05 25.2 0.2 3.6e-05 24.1 0.2 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EKE42207.1 - 0.00029 20.3 0.6 0.00071 19.0 0.0 1.9 2 0 0 2 2 2 1 KaiC HA2 PF04408.23 EKE42207.1 - 0.00053 20.2 0.0 0.0018 18.5 0.0 1.9 2 0 0 2 2 1 1 Helicase associated domain (HA2) AAA_30 PF13604.6 EKE42207.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EKE42207.1 - 0.025 15.1 0.4 0.066 13.7 0.0 1.9 2 0 0 2 2 1 0 ABC transporter Sigma54_activat PF00158.26 EKE42207.1 - 0.026 14.2 0.0 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain T2SSE PF00437.20 EKE42207.1 - 0.037 13.1 0.0 0.067 12.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Helicase_RecD PF05127.14 EKE42207.1 - 0.049 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Helicase AAA_14 PF13173.6 EKE42207.1 - 0.051 13.6 0.0 0.41 10.7 0.0 2.6 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EKE42207.1 - 0.053 13.4 0.1 0.48 10.3 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EKE42207.1 - 0.066 13.6 0.0 0.18 12.2 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 EKE42207.1 - 0.072 12.5 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein Rad17 PF03215.15 EKE42207.1 - 0.087 12.7 0.0 0.53 10.2 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 EKE42207.1 - 0.12 12.3 0.1 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA_25 PF13481.6 EKE42207.1 - 0.24 11.0 0.0 0.48 10.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EKE42207.1 - 0.54 10.7 2.4 0.57 10.6 0.0 2.3 2 1 0 2 2 2 0 AAA domain Cyclin_N PF00134.23 EKE42208.1 - 4e-09 36.3 0.2 4e-09 36.3 0.2 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain LRR_5 PF13306.6 EKE42211.1 - 1.5e-39 134.9 30.3 4.4e-25 88.1 14.1 3.0 3 0 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE42211.1 - 2.1e-09 37.0 0.0 0.002 17.9 0.0 4.7 2 2 3 5 5 5 5 Leucine rich repeat MIG-14_Wnt-bd PF06664.12 EKE42212.1 - 4.4e-47 160.7 32.1 5.4e-47 160.4 32.1 1.1 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion Hol_Tox PF16935.5 EKE42212.1 - 0.12 12.4 0.6 11 6.1 0.2 3.1 2 1 1 3 3 3 0 Putative Holin-like Toxin (Hol-Tox) Paramyxo_PNT PF14320.6 EKE42212.1 - 0.14 11.3 0.7 0.2 10.8 0.7 1.1 1 0 0 1 1 1 0 Phosphoprotein P region PNT disordered DUF4010 PF13194.6 EKE42212.1 - 4.3 7.0 11.1 0.37 10.5 2.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4010) DUF4949 PF16307.5 EKE42213.1 - 0.011 15.9 0.4 0.015 15.4 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4949) V_ATPase_I PF01496.19 EKE42214.1 - 0.0072 14.3 0.3 0.0095 13.9 0.3 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family 7TM_GPCR_Sru PF10322.9 EKE42214.1 - 0.0084 15.5 2.1 0.013 14.9 2.1 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Sru 7tm_1 PF00001.21 EKE42214.1 - 0.017 14.5 0.2 0.026 13.9 0.2 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 EKE42214.1 - 0.034 13.5 0.7 0.054 12.8 0.7 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv Zip PF02535.22 EKE42214.1 - 0.035 13.3 0.3 0.035 13.3 0.3 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 EKE42214.1 - 0.08 13.0 0.4 0.13 12.3 0.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Mucin PF01456.17 EKE42214.1 - 0.13 12.3 1.4 0.25 11.3 1.4 1.5 1 1 0 1 1 1 0 Mucin-like glycoprotein Anophelin PF10731.9 EKE42214.1 - 0.52 10.2 2.2 1.2 9.0 2.2 1.6 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito UPF0542 PF15086.6 EKE42214.1 - 0.94 9.4 4.7 0.23 11.4 0.3 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 Dsh_C PF12316.8 EKE42214.1 - 2.3 8.6 4.6 3 8.2 4.6 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Connexin PF00029.19 EKE42214.1 - 5.9 6.6 7.4 16 5.2 7.4 1.6 1 1 0 1 1 1 0 Connexin Importin_rep_4 PF18808.1 EKE42215.1 - 0.66 10.3 10.4 0.29 11.4 3.0 2.6 2 0 0 2 2 2 0 Importin repeat Pescadillo_N PF06732.11 EKE42216.1 - 8.6e-79 264.9 9.1 8.6e-79 264.9 9.1 2.1 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EKE42216.1 - 6.9e-12 45.6 0.0 2e-11 44.1 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EKE42216.1 - 0.00055 20.2 0.4 0.0038 17.5 0.0 2.7 3 0 0 3 3 3 1 DNA ligase 3 BRCT domain BRCT PF00533.26 EKE42216.1 - 0.0016 18.8 0.0 0.0062 16.9 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain XPG_I PF00867.18 EKE42216.1 - 0.52 10.7 2.3 3.1 8.2 0.0 3.0 2 1 0 2 2 2 0 XPG I-region Ras PF00071.22 EKE42217.1 - 1.5e-26 92.9 0.0 2.3e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42217.1 - 1.8e-16 60.4 0.0 7.8e-16 58.4 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42217.1 - 1.9e-06 27.5 0.0 2.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE42217.1 - 0.00081 19.5 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EKE42217.1 - 0.0018 18.2 0.0 1.9 8.4 0.0 2.7 3 0 0 3 3 3 2 RsgA GTPase Gtr1_RagA PF04670.12 EKE42217.1 - 0.012 15.0 0.0 0.017 14.5 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region KAP_NTPase PF07693.14 EKE42217.1 - 0.052 12.8 0.0 0.18 11.0 0.0 1.7 1 1 0 1 1 1 0 KAP family P-loop domain TsaE PF02367.17 EKE42217.1 - 0.064 13.3 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EKE42217.1 - 0.13 12.5 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cauli_VI PF01693.16 EKE42218.1 - 2.4e-16 59.8 0.9 4.8e-16 58.8 0.9 1.5 1 0 0 1 1 1 1 Caulimovirus viroplasmin PP2C PF00481.21 EKE42219.1 - 1.5e-54 185.3 0.0 2.2e-54 184.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 EKE42219.1 - 1e-17 63.9 54.8 2.6e-05 24.5 1.4 8.6 5 3 4 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE42219.1 - 1.7e-14 53.3 45.8 2.1e-06 27.4 3.8 7.8 3 3 5 8 8 8 6 Leucine rich repeat PP2C_2 PF13672.6 EKE42219.1 - 0.14 11.8 0.0 0.38 10.4 0.0 1.8 1 1 0 1 1 1 0 Protein phosphatase 2C LRR_1 PF00560.33 EKE42219.1 - 0.48 11.2 49.3 8.1 7.4 0.8 11.4 12 0 0 12 12 12 0 Leucine Rich Repeat preATP-grasp_3 PF18301.1 EKE42220.1 - 0.034 14.4 0.0 0.17 12.2 0.0 2.0 3 0 0 3 3 3 0 pre ATP-grasp 3 domain Beta-TrCP_D PF12125.8 EKE42220.1 - 0.088 12.7 3.3 0.45 10.5 0.1 3.0 3 0 0 3 3 3 0 D domain of beta-TrCP TFIID_20kDa PF03847.13 EKE42220.1 - 0.51 10.9 2.7 3.7 8.1 0.0 3.0 3 0 0 3 3 3 0 Transcription initiation factor TFIID subunit A TAFII28 PF04719.14 EKE42221.1 - 0.14 12.2 0.1 3.3 7.9 0.1 2.7 2 0 0 2 2 2 0 hTAFII28-like protein conserved region I_LWEQ PF01608.17 EKE42223.1 - 2.3e-25 89.6 2.6 2.3e-25 89.6 2.6 5.9 4 1 0 6 6 6 1 I/LWEQ domain FERM_M PF00373.18 EKE42223.1 - 2.3e-21 76.4 0.2 3.9e-20 72.4 0.0 3.2 3 0 0 3 3 3 1 FERM central domain FERM_f0 PF16511.5 EKE42223.1 - 2.4e-14 53.4 0.5 9.9e-13 48.2 0.4 3.0 2 0 0 2 2 2 1 N-terminal or F0 domain of Talin-head FERM FERM_N PF09379.10 EKE42223.1 - 0.0028 17.6 0.2 0.15 12.1 0.0 3.3 3 0 0 3 3 3 1 FERM N-terminal domain T3SS_needle_F PF09392.10 EKE42223.1 - 0.24 11.6 7.6 0.35 11.1 0.2 4.2 3 0 0 3 3 3 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF CactinC_cactus PF09732.9 EKE42224.1 - 2.4e-14 53.3 1.9 3.9e-14 52.6 1.9 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PdaC PF13739.6 EKE42224.1 - 1.2 10.1 4.4 3.5 8.7 0.3 2.3 2 0 0 2 2 2 0 Deacetylase PdaC Phosducin PF02114.16 EKE42225.1 - 3.2e-13 49.2 4.3 3.1e-11 42.7 4.3 2.1 1 1 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 EKE42225.1 - 0.012 15.5 0.1 0.024 14.6 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin DUF3435 PF11917.8 EKE42225.1 - 0.076 11.9 3.6 0.09 11.7 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) DUF5446 PF17522.2 EKE42225.1 - 0.16 12.2 6.5 3.7 7.8 0.7 2.5 1 1 1 2 2 2 0 Family of unknown function (DUF5446) RNA_pol_N PF01194.17 EKE42226.1 - 2.7 8.3 4.8 1 9.7 0.3 2.8 2 1 0 2 2 2 0 RNA polymerases N / 8 kDa subunit DUF1844 PF08899.11 EKE42226.1 - 4.7 7.6 10.4 1.1 9.6 3.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1844) DUF4187 PF13821.6 EKE42227.1 - 1.4e-07 31.2 3.4 4.1e-07 29.7 3.4 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) DUF3546 PF12066.8 EKE42227.1 - 4.1e-06 27.0 3.9 4.1e-06 27.0 3.9 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) zf-C3HC4 PF00097.25 EKE42227.1 - 4.7 7.2 5.6 9.2 6.2 0.2 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Autophagy_N PF03986.13 EKE42228.1 - 1.1e-31 109.5 0.1 1.8e-31 108.9 0.1 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 EKE42228.1 - 3.2e-13 48.9 1.2 5.6e-13 48.1 1.2 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 EKE42228.1 - 1.4e-12 48.0 0.7 2.9e-12 47.0 0.2 1.8 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain TMEM144 PF07857.12 EKE42229.1 - 5.2e-92 308.4 12.2 1.1e-90 304.0 12.2 2.0 1 1 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 EKE42229.1 - 3.5e-08 33.1 20.7 7.2e-07 28.8 5.4 2.9 3 0 0 3 3 3 2 Sugar transport protein Ureide_permease PF07168.11 EKE42229.1 - 1.2e-06 27.6 3.7 0.00027 19.8 3.7 2.7 1 1 0 1 1 1 1 Ureide permease Nab6_mRNP_bdg PF10567.9 EKE42229.1 - 0.03 13.8 3.4 0.051 13.1 3.4 1.3 1 0 0 1 1 1 0 RNA-recognition motif Shisa PF13908.6 EKE42229.1 - 0.16 12.2 0.1 0.16 12.2 0.1 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator V_ATPase_I PF01496.19 EKE42229.1 - 0.26 9.1 1.3 0.47 8.3 1.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2407_C PF13373.6 EKE42229.1 - 0.88 9.7 3.5 8.3 6.6 0.0 2.8 2 1 0 2 2 2 0 DUF2407 C-terminal domain GET2 PF08690.10 EKE42229.1 - 0.94 9.1 5.7 0.12 12.0 1.3 1.6 2 0 0 2 2 2 0 GET complex subunit GET2 FancD2 PF14631.6 EKE42229.1 - 1.3 6.3 3.1 1.7 5.9 3.1 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF4820 PF16091.5 EKE42229.1 - 1.8 7.9 5.5 2.5 7.4 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PNISR PF15996.5 EKE42229.1 - 4.7 7.4 13.4 6.4 7.0 13.4 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Coatomer_WDAD PF04053.14 EKE42230.1 - 3.4e-05 23.1 3.1 0.027 13.5 0.1 2.6 2 0 0 2 2 2 2 Coatomer WD associated region dCache_2 PF08269.11 EKE42230.1 - 0.13 11.5 1.9 0.45 9.6 0.0 2.4 3 0 0 3 3 3 0 Cache domain PADR1 PF08063.12 EKE42230.1 - 1.5 8.7 5.5 2 8.2 0.5 2.8 2 0 0 2 2 2 0 PADR1 (NUC008) domain Rsa3 PF14615.6 EKE42231.1 - 1.1e-14 53.7 0.1 2e-14 52.9 0.1 1.4 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Hamartin PF04388.12 EKE42231.1 - 2.7 6.5 36.9 3.1 6.4 36.9 1.0 1 0 0 1 1 1 0 Hamartin protein Yop-YscD_cpl PF16697.5 EKE42232.1 - 0.1 12.9 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Ras PF00071.22 EKE42234.1 - 4.7e-49 166.1 0.0 6.2e-49 165.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42234.1 - 1.1e-22 80.5 0.0 1.7e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42234.1 - 4.3e-07 29.6 0.0 6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF3818 PF12825.7 EKE42234.1 - 0.1 11.6 0.3 0.27 10.2 0.4 1.6 1 1 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) Snf7 PF03357.21 EKE42235.1 - 7.6e-26 90.7 17.3 7.6e-26 90.7 17.3 1.6 2 0 0 2 2 2 1 Snf7 TPR_MLP1_2 PF07926.12 EKE42235.1 - 0.081 13.0 6.5 0.18 11.8 6.5 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein YqaH PF17448.2 EKE42235.1 - 0.29 11.4 5.8 4.9 7.5 0.2 2.7 1 1 2 3 3 3 0 Uncharacterized YqaH-like FlxA PF14282.6 EKE42235.1 - 7.7 6.6 8.3 0.19 11.7 1.1 2.1 2 1 0 2 2 2 0 FlxA-like protein Spc24 PF08286.11 EKE42235.1 - 7.9 6.8 15.1 1.1 9.5 3.6 3.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 ProRS-C_1 PF09180.11 EKE42236.1 - 1.9e-22 79.2 4.1 8.7e-22 77.1 4.0 2.2 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EKE42236.1 - 7.5e-20 71.6 0.0 1.5e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EKE42236.1 - 9.6e-17 60.9 0.0 2e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain LisH PF08513.11 EKE42237.1 - 0.00012 21.9 0.0 0.0004 20.2 0.0 2.0 1 0 0 1 1 1 1 LisH zf-CRD PF17979.1 EKE42237.1 - 0.008 16.3 3.5 0.011 15.9 0.9 2.7 2 0 0 2 2 2 1 Cysteine rich domain with multizinc binding regions PH PF00169.29 EKE42238.1 - 8e-15 55.2 1.0 2.4e-14 53.7 0.8 1.8 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EKE42238.1 - 0.0013 19.1 0.5 0.0025 18.2 0.5 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EKE42238.1 - 0.14 12.3 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 PH domain Slu7 PF11708.8 EKE42239.1 - 0.0099 15.7 14.7 0.016 15.0 14.6 1.5 1 1 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_3 PF13917.6 EKE42239.1 - 0.028 14.4 1.1 0.059 13.3 1.1 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EKE42239.1 - 0.1 12.7 2.2 0.1 12.7 2.2 1.5 2 0 0 2 2 2 0 Zinc knuckle DSPc PF00782.20 EKE42239.1 - 0.26 11.1 4.7 0.54 10.1 4.7 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain DUF4407 PF14362.6 EKE42239.1 - 6 6.1 8.1 7.2 5.9 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TssO PF17561.2 EKE42239.1 - 7.5 6.6 19.0 11 6.1 19.0 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssO WD40 PF00400.32 EKE42240.1 - 2.3e-08 34.5 0.1 0.056 14.3 0.0 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE42240.1 - 0.0013 19.0 0.0 2.7 8.3 0.0 3.6 4 2 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_L39 PF00832.20 EKE42242.1 - 1.7e-20 72.4 5.7 1.9e-20 72.2 5.7 1.0 1 0 0 1 1 1 1 Ribosomal L39 protein Chitin_synth_2 PF03142.15 EKE42243.1 - 7.1e-23 81.0 0.0 7.1e-23 81.0 0.0 4.4 4 1 1 5 5 5 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EKE42243.1 - 1e-17 64.7 0.0 1e-17 64.7 0.0 3.3 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EKE42243.1 - 4.5e-07 30.0 0.0 7.2e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EKE42243.1 - 0.0018 18.1 0.0 0.0082 16.0 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 Galactosyl_T PF01762.21 EKE42243.1 - 0.066 13.0 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Galactosyltransferase Sen15 PF09631.10 EKE42243.1 - 0.15 12.4 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 Sen15 protein TPR_1 PF00515.28 EKE42244.1 - 4.7e-10 38.8 0.5 6.7e-05 22.5 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat FKBP_C PF00254.28 EKE42244.1 - 2.3e-08 34.2 0.0 4.3e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 EKE42244.1 - 6.2e-07 29.1 0.5 0.0012 18.8 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EKE42244.1 - 0.002 18.2 0.0 0.0047 17.0 0.0 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EKE42244.1 - 0.012 15.8 0.0 0.032 14.4 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 EKE42244.1 - 0.077 13.7 0.1 0.19 12.4 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat SecA_PP_bind PF01043.20 EKE42244.1 - 0.092 13.4 0.9 0.25 12.0 0.2 1.9 2 0 0 2 2 2 0 SecA preprotein cross-linking domain TPR_14 PF13428.6 EKE42244.1 - 0.11 13.3 0.1 0.27 12.2 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_21 PF09976.9 EKE42244.1 - 0.13 12.0 0.1 0.5 10.1 0.1 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain Pkinase PF00069.25 EKE42245.1 - 2.2e-35 122.3 0.0 3.3e-35 121.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42245.1 - 1.9e-16 60.2 1.5 2.5e-15 56.5 0.3 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 EKE42245.1 - 0.0029 16.7 0.7 0.0052 15.9 0.7 1.5 1 1 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.22 EKE42245.1 - 0.0054 16.3 0.1 0.0096 15.5 0.1 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EKE42245.1 - 0.019 14.9 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EKE42245.1 - 0.033 13.5 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Baculo_PP31 PF05311.11 EKE42245.1 - 0.26 10.8 3.2 0.39 10.2 3.2 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) DUF919 PF06034.11 EKE42246.1 - 0.05 13.5 3.3 0.14 12.0 3.3 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) NTF2 PF02136.20 EKE42247.1 - 1.1e-20 74.4 0.3 1.3e-20 74.2 0.3 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SNF2_N PF00176.23 EKE42248.1 - 4.6e-60 203.2 0.4 1.1e-59 202.0 0.4 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE42248.1 - 1.3e-22 80.2 1.2 6.4e-22 78.0 0.1 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SLIDE PF09111.10 EKE42248.1 - 4e-16 59.1 1.3 4e-16 59.1 1.3 3.4 3 0 0 3 3 3 1 SLIDE ResIII PF04851.15 EKE42248.1 - 2.6e-08 34.0 0.0 2.6e-08 34.0 0.0 3.7 5 1 0 5 5 5 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EKE42248.1 - 5.4e-05 22.5 1.2 0.00015 21.1 0.1 2.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 EKE42248.1 - 7.4e-05 22.6 0.0 0.0003 20.6 0.0 2.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 EKE42248.1 - 0.00093 18.4 1.5 0.00093 18.4 1.5 3.1 3 1 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-bind_6 PF13921.6 EKE42248.1 - 0.055 13.7 2.0 1.3 9.3 0.1 3.2 2 0 0 2 2 2 0 Myb-like DNA-binding domain Radical_SAM PF04055.21 EKE42248.1 - 0.17 12.3 1.0 1.6 9.1 0.1 3.1 3 0 0 3 3 3 0 Radical SAM superfamily ArsC PF03960.15 EKE42248.1 - 0.73 9.9 4.5 21 5.2 0.1 3.9 3 1 1 4 4 4 0 ArsC family EF-hand_7 PF13499.6 EKE42249.1 - 3e-27 94.9 26.1 5.4e-10 39.6 0.4 7.8 5 2 3 8 8 8 8 EF-hand domain pair EF-hand_1 PF00036.32 EKE42249.1 - 3.6e-17 60.5 23.4 0.0028 17.1 0.1 9.7 10 0 0 10 10 10 7 EF hand EF-hand_8 PF13833.6 EKE42249.1 - 2.1e-12 46.7 9.8 0.00015 21.6 0.0 6.3 4 2 1 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.6 EKE42249.1 - 2.3e-12 45.8 24.5 0.33 11.0 0.1 10.7 9 2 1 11 11 11 5 EF-hand domain EF-hand_5 PF13202.6 EKE42249.1 - 1.5e-08 33.8 5.7 0.081 12.5 0.1 6.1 5 0 0 5 5 5 3 EF hand EF-hand_4 PF12763.7 EKE42249.1 - 0.00012 22.0 13.5 0.049 13.6 0.0 6.3 4 3 3 7 7 7 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EKE42249.1 - 0.0015 18.9 14.7 0.27 11.6 0.5 5.6 4 1 1 5 5 5 1 Secreted protein acidic and rich in cysteine Ca binding region FemAB_like PF04339.12 EKE42249.1 - 0.032 13.4 0.3 0.36 9.9 0.1 2.1 2 0 0 2 2 2 0 Peptidogalycan biosysnthesis/recognition EF-hand_like PF09279.11 EKE42249.1 - 0.039 14.4 4.2 0.31 11.6 0.3 3.6 3 0 0 3 3 3 0 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_9 PF14658.6 EKE42249.1 - 0.045 14.1 1.8 5.9 7.3 0.1 3.3 3 0 0 3 3 3 0 EF-hand domain DUF3737 PF12541.8 EKE42250.1 - 0.0079 15.4 0.6 0.0097 15.1 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3737) RRP7 PF12923.7 EKE42250.1 - 0.012 15.8 4.9 0.012 15.8 4.9 1.9 1 1 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain ATP13 PF12921.7 EKE42250.1 - 0.024 14.5 0.4 0.033 14.1 0.4 1.2 1 0 0 1 1 1 0 Mitochondrial ATPase expression zf-CRD PF17979.1 EKE42250.1 - 0.11 12.6 0.5 0.14 12.3 0.5 1.3 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions RRM_1 PF00076.22 EKE42251.1 - 0.0074 16.1 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NAC PF01849.18 EKE42252.1 - 1.1e-15 57.3 1.4 1.7e-15 56.7 0.1 2.0 2 0 0 2 2 2 1 NAC domain RRP7 PF12923.7 EKE42252.1 - 0.00076 19.6 4.1 0.0013 18.9 4.1 1.4 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF4193 PF13834.6 EKE42252.1 - 0.0072 16.8 1.7 0.011 16.2 1.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4193) Transposase_24 PF03004.14 EKE42252.1 - 0.01 16.0 2.7 0.015 15.4 2.7 1.4 1 1 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) NPL PF17800.1 EKE42254.1 - 2.3e-08 34.6 0.3 7.8e-08 32.8 0.1 1.8 2 0 0 2 2 2 1 Nucleoplasmin-like domain PAP2 PF01569.21 EKE42255.1 - 4.4e-24 84.8 2.8 4.4e-24 84.8 2.8 1.6 2 1 0 2 2 2 1 PAP2 superfamily Peptidase_A22B PF04258.13 EKE42255.1 - 0.11 12.0 8.9 0.15 11.6 2.8 2.3 2 1 0 2 2 2 0 Signal peptide peptidase DUF4131 PF13567.6 EKE42255.1 - 0.55 9.9 4.0 28 4.3 4.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Pox_A14 PF05767.12 EKE42255.1 - 1.2 9.3 8.4 9.3 6.5 2.4 3.0 2 2 0 2 2 2 0 Poxvirus virion envelope protein A14 TMEM251 PF15190.6 EKE42255.1 - 1.3 9.0 8.2 0.64 10.0 3.7 2.4 3 0 0 3 3 3 0 Transmembrane protein 251 DAO PF01266.24 EKE42255.1 - 2.2 7.8 3.4 3.4 7.2 3.4 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Reo_P9 PF06043.11 EKE42256.1 - 0.0092 15.4 0.1 0.017 14.6 0.1 1.4 1 0 0 1 1 1 1 Reovirus P9-like family Endonuc-MspI PF09208.10 EKE42256.1 - 0.023 14.1 1.5 0.091 12.1 0.4 2.2 2 0 0 2 2 2 0 Restriction endonuclease MspI DUF2615 PF11027.8 EKE42256.1 - 0.15 12.3 1.6 0.34 11.0 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) RabGAP-TBC PF00566.18 EKE42258.1 - 7.5e-36 123.8 7.7 7.5e-36 123.8 7.7 3.3 3 1 0 3 3 3 1 Rab-GTPase-TBC domain Mhr1 PF12829.7 EKE42258.1 - 0.037 14.1 0.3 0.12 12.4 0.3 1.9 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination Ank_5 PF13857.6 EKE42258.1 - 0.19 12.1 0.0 0.38 11.1 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) DZF PF07528.14 EKE42258.1 - 3.1 7.4 5.7 5.7 6.5 5.7 1.4 1 0 0 1 1 1 0 DZF domain DUF2514 PF10721.9 EKE42258.1 - 9 6.3 9.1 19 5.2 9.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Ras PF00071.22 EKE42261.1 - 2e-40 138.1 1.7 2.3e-40 137.8 1.7 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42261.1 - 2e-24 86.1 0.2 3e-24 85.5 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42261.1 - 1.2e-10 41.2 0.2 1.5e-10 40.8 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE42261.1 - 2.2e-06 27.7 0.1 0.0012 18.8 0.2 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EKE42261.1 - 4.4e-05 23.1 0.2 0.0026 17.3 0.1 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EKE42261.1 - 0.0012 18.6 1.5 0.01 15.6 1.5 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EKE42261.1 - 0.019 15.0 0.1 0.03 14.4 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Exo_endo_phos PF03372.23 EKE42262.1 - 0.00045 19.8 0.0 0.00083 18.9 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ig_GlcNase PF18368.1 EKE42262.1 - 0.0047 17.1 0.0 0.0095 16.1 0.0 1.4 1 0 0 1 1 1 1 Exo-beta-D-glucosaminidase Ig-fold domain PapD-like PF14874.6 EKE42262.1 - 0.016 15.3 0.0 0.032 14.4 0.0 1.5 1 0 0 1 1 1 0 Flagellar-associated PapD-like WD40 PF00400.32 EKE42264.1 - 3.8e-10 40.2 8.7 3.1e-05 24.6 0.1 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE42264.1 - 1.7e-08 34.6 0.1 0.0009 19.5 0.0 5.0 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EKE42264.1 - 3e-05 24.0 0.2 0.0035 17.2 0.1 2.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 EKE42264.1 - 0.0094 15.7 1.3 0.74 9.5 0.3 2.5 2 0 0 2 2 2 1 TUP1-like enhancer of split Nbas_N PF15492.6 EKE42264.1 - 0.042 13.2 0.4 7.4 5.8 0.0 3.1 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal FleQ PF06490.11 EKE42264.1 - 0.13 12.7 0.1 0.34 11.3 0.1 1.7 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ TFIIIC_delta PF12657.7 EKE42264.1 - 0.23 11.4 1.7 1.6 8.6 0.0 2.7 3 1 1 4 4 4 0 Transcription factor IIIC subunit delta N-term Pkinase PF00069.25 EKE42266.1 - 1.4e-38 132.8 0.5 1.7e-38 132.5 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42266.1 - 4.9e-27 94.8 0.1 5.7e-27 94.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE42266.1 - 0.00026 20.4 0.1 0.00037 19.9 0.1 1.4 1 0 0 1 1 1 1 Kinase-like RasGAP PF00616.19 EKE42267.1 - 1.8e-28 99.7 2.2 8.7e-19 68.1 0.0 2.9 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase FAST_1 PF06743.15 EKE42267.1 - 0.24 11.4 1.8 2.6 8.0 0.2 2.9 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 LRR_1 PF00560.33 EKE42267.1 - 3.8 8.4 11.1 27 5.8 0.1 5.8 5 0 0 5 5 5 0 Leucine Rich Repeat Spc24 PF08286.11 EKE42269.1 - 0.0067 16.7 6.6 0.0067 16.7 6.6 4.4 1 1 1 3 3 3 1 Spc24 subunit of Ndc80 TPR_MLP1_2 PF07926.12 EKE42269.1 - 0.0098 16.0 19.4 0.0098 16.0 19.4 4.4 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein Mem_trans PF03547.18 EKE42270.1 - 4.3e-11 41.9 13.0 5.4e-11 41.5 13.0 1.1 1 0 0 1 1 1 1 Membrane transport protein Phage_holin_3_3 PF16083.5 EKE42270.1 - 0.027 14.6 0.6 5 7.3 0.0 3.0 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III RhoGEF PF00621.20 EKE42271.1 - 9.3e-34 117.2 2.1 9.3e-34 117.2 2.1 3.4 2 1 0 2 2 2 1 RhoGEF domain DUF5405 PF17399.2 EKE42273.1 - 0.0039 17.4 0.1 0.14 12.4 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF5405) IMD PF08397.11 EKE42273.1 - 0.004 16.6 10.3 0.007 15.8 7.7 2.6 3 1 0 3 3 3 1 IRSp53/MIM homology domain Imm7 PF15585.6 EKE42273.1 - 0.016 15.5 0.5 0.043 14.1 0.5 1.8 1 0 0 1 1 1 0 Immunity protein 7 Peroxin-13_N PF04088.13 EKE42273.1 - 1.7 8.9 5.5 1 9.6 1.8 2.5 3 0 0 3 3 3 0 Peroxin 13, N-terminal region Pkinase PF00069.25 EKE42274.1 - 5.1e-33 114.6 1.6 6.5e-33 114.2 1.6 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42274.1 - 6e-17 61.8 1.6 8.9e-17 61.2 1.6 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE42274.1 - 0.0001 21.7 0.1 0.0048 16.2 0.0 2.4 1 1 1 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 EKE42274.1 - 0.012 14.7 3.3 0.012 14.7 3.3 1.9 1 1 1 2 2 2 0 Seadornavirus VP7 Haspin_kinase PF12330.8 EKE42274.1 - 0.047 12.6 2.9 0.11 11.4 2.9 1.6 1 1 0 1 1 1 0 Haspin like kinase domain RhoGEF PF00621.20 EKE42275.1 - 3.4e-43 148.0 7.5 3.4e-43 148.0 7.5 3.0 3 1 0 3 3 3 1 RhoGEF domain CEBP_ZZ PF16366.5 EKE42275.1 - 0.014 15.7 10.8 0.014 15.7 10.8 2.4 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-B_box PF00643.24 EKE42275.1 - 0.015 15.5 7.9 0.015 15.5 7.9 2.3 2 0 0 2 2 2 0 B-box zinc finger TMEM237 PF15383.6 EKE42275.1 - 7.6 5.6 7.3 1.2 8.2 2.8 1.9 2 0 0 2 2 2 0 Transmembrane protein 237 Chorein_N PF12624.7 EKE42276.1 - 2.2e-15 56.8 4.3 2.3e-15 56.7 0.1 3.3 3 1 0 3 3 3 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EKE42276.1 - 0.00016 21.5 2.0 0.0029 17.4 0.0 2.9 3 0 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal TA0956 PF11513.8 EKE42278.1 - 0.054 13.7 0.2 0.089 13.0 0.2 1.4 1 0 0 1 1 1 0 Thermoplasma acidophilum protein TA0956 RhoGAP PF00620.27 EKE42280.1 - 9.2e-27 93.7 0.4 1.5e-26 93.1 0.4 1.3 1 0 0 1 1 1 1 RhoGAP domain VSP PF03302.13 EKE42281.1 - 1e-05 24.6 36.0 1e-05 24.6 36.0 5.4 1 1 5 6 6 6 3 Giardia variant-specific surface protein Furin-like_2 PF15913.5 EKE42281.1 - 0.019 15.1 16.7 0.019 15.1 16.7 7.3 2 1 5 7 7 7 0 Furin-like repeat, cysteine-rich DUF4215 PF13948.6 EKE42281.1 - 0.028 14.8 8.2 0.028 14.8 8.2 9.5 6 2 2 8 8 8 0 Domain of unknown function (DUF4215) Fe-ADH PF00465.19 EKE42282.1 - 7.5e-65 219.1 0.0 8.1e-65 219.0 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EKE42282.1 - 2.6e-05 24.1 0.1 3.7e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Rap_GAP PF02145.15 EKE42283.1 - 0.00023 20.8 0.0 0.00074 19.1 0.0 1.9 1 0 0 1 1 1 1 Rap/ran-GAP IKI3 PF04762.12 EKE42284.1 - 4.7e-54 183.8 10.0 1.4e-53 182.2 7.1 2.6 2 1 0 2 2 2 2 IKI3 family RabGAP-TBC PF00566.18 EKE42285.1 - 8.9e-43 146.4 7.7 1.4e-42 145.8 7.7 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LMSTEN PF07988.12 EKE42285.1 - 0.092 12.2 0.0 0.36 10.3 0.0 2.0 2 0 0 2 2 2 0 LMSTEN motif TPR_1 PF00515.28 EKE42286.1 - 1.5e-37 125.9 24.6 3.7e-07 29.7 0.1 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 EKE42286.1 - 8.9e-36 119.1 24.1 5e-05 23.1 0.0 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 EKE42286.1 - 8.6e-30 100.4 22.5 1.3e-05 25.0 0.3 8.8 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_11 PF13414.6 EKE42286.1 - 1.7e-24 85.2 16.2 1.3e-09 37.6 0.1 7.7 4 3 3 7 7 7 5 TPR repeat TPR_17 PF13431.6 EKE42286.1 - 4.3e-23 80.0 19.0 0.016 15.5 0.0 8.5 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_14 PF13428.6 EKE42286.1 - 1.5e-20 72.1 0.7 0.014 16.1 0.2 6.7 2 2 4 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 EKE42286.1 - 5e-15 55.8 7.7 0.00016 22.1 0.0 5.3 2 2 4 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 EKE42286.1 - 3.5e-13 50.0 2.6 0.061 14.0 0.4 5.2 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EKE42286.1 - 3.9e-13 48.4 4.6 0.0017 18.3 0.5 6.3 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 EKE42286.1 - 1.4e-11 44.2 6.8 0.01 16.4 0.2 7.2 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 EKE42286.1 - 2.5e-10 40.5 17.6 0.0026 18.0 1.7 6.1 3 2 3 6 6 5 5 Tetratricopeptide repeat TPR_9 PF13371.6 EKE42286.1 - 6.7e-09 35.8 0.2 0.0058 16.7 0.0 4.4 2 2 1 4 4 4 3 Tetratricopeptide repeat TPR_15 PF13429.6 EKE42286.1 - 4.4e-07 29.4 0.8 0.021 14.0 0.1 3.3 2 2 1 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE42286.1 - 9.6e-07 28.9 19.6 0.031 14.5 5.2 3.5 3 1 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EKE42286.1 - 5.9e-05 22.8 9.0 1.6 8.7 0.2 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat RPN7 PF10602.9 EKE42286.1 - 0.0026 17.5 1.6 8.6 6.0 0.0 3.6 2 1 1 3 3 3 0 26S proteasome subunit RPN7 NARP1 PF12569.8 EKE42286.1 - 0.018 14.0 1.9 0.46 9.3 0.0 3.0 2 1 0 3 3 3 0 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 EKE42286.1 - 0.022 15.1 0.8 28 5.1 0.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF4919 PF16266.5 EKE42286.1 - 0.026 14.5 1.2 0.043 13.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4919) MIT PF04212.18 EKE42286.1 - 0.032 14.3 6.4 1.6 8.8 0.0 4.6 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain ChAPs PF09295.10 EKE42286.1 - 0.064 12.2 0.6 4.4 6.2 0.1 2.5 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TOM20_plant PF06552.12 EKE42286.1 - 0.37 10.5 2.5 8.3 6.1 0.0 3.6 3 1 1 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 Fis1_TPR_C PF14853.6 EKE42286.1 - 2 8.5 5.0 7.1 6.8 0.0 3.5 3 1 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat DEAD PF00270.29 EKE42287.1 - 1.2e-41 142.4 0.1 2.7e-41 141.2 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE42287.1 - 1.5e-27 96.2 0.4 1.5e-27 96.2 0.4 3.5 4 0 0 4 4 4 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EKE42287.1 - 1.1e-17 64.0 0.0 2e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EKE42287.1 - 5.2e-06 26.6 6.0 1.2e-05 25.4 0.1 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Terminase_6 PF03237.15 EKE42287.1 - 0.014 15.1 0.0 24 4.5 0.0 3.4 3 1 0 3 3 3 0 Terminase-like family Ribosomal_S8 PF00410.19 EKE42287.1 - 0.75 9.8 3.7 0.54 10.2 0.6 2.2 2 0 0 2 2 2 0 Ribosomal protein S8 Metallophos PF00149.28 EKE42288.1 - 1.2e-34 120.6 0.2 2.3e-34 119.7 0.2 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase S4 PF01479.25 EKE42288.1 - 0.26 11.0 0.5 0.51 10.1 0.0 1.7 2 0 0 2 2 2 0 S4 domain Syntaxin PF00804.25 EKE42289.1 - 7.8e-21 74.7 13.3 7.8e-21 74.7 13.3 1.5 2 0 0 2 2 2 1 Syntaxin T2SSF PF00482.23 EKE42289.1 - 0.0022 17.9 1.1 0.0083 16.1 0.5 2.1 2 1 0 2 2 2 1 Type II secretion system (T2SS), protein F DUF3377 PF11857.8 EKE42289.1 - 0.042 13.8 2.9 0.15 12.0 2.9 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) SMYLE_N PF18615.1 EKE42289.1 - 0.39 10.2 5.7 0.53 9.8 5.7 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain MCPsignal PF00015.21 EKE42289.1 - 0.48 10.2 6.1 0.46 10.3 2.0 2.1 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Shisa PF13908.6 EKE42289.1 - 0.91 9.7 4.7 0.19 12.0 1.2 1.7 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF2207 PF09972.9 EKE42289.1 - 2 7.1 12.8 6.7 5.4 12.8 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2116 PF09889.9 EKE42289.1 - 2.8 8.0 6.1 0.76 9.8 1.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) PPP5 PF08321.12 EKE42289.1 - 3.8 7.9 9.8 0.46 10.8 0.7 2.7 1 1 1 2 2 2 0 PPP5 TPR repeat region Salp15 PF12115.8 EKE42289.1 - 5.5 7.4 6.4 3.5 8.1 0.8 2.6 1 1 0 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation ETRAMP PF09716.10 EKE42289.1 - 6.6 6.9 11.7 2.3e+02 2.0 11.7 3.0 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) FokI_N PF02981.15 EKE42289.1 - 9.9 6.3 6.7 7.3 6.8 0.4 2.3 1 1 1 2 2 2 0 Restriction endonuclease FokI, recognition domain Ribosomal_S30 PF04758.14 EKE42290.1 - 3.9e-23 81.4 4.0 4.4e-23 81.2 4.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 PCI PF01399.27 EKE42291.1 - 5.9e-17 62.1 1.2 5.9e-17 62.1 1.2 2.5 3 1 0 3 3 3 1 PCI domain RPN6_N PF18055.1 EKE42291.1 - 2.9e-11 43.8 0.2 2.9e-11 43.8 0.2 2.5 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_16 PF13432.6 EKE42291.1 - 0.00023 21.7 0.1 0.00041 20.9 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 EKE42291.1 - 0.0027 18.0 1.9 0.035 14.4 0.6 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Vps39_1 PF10366.9 EKE42291.1 - 0.018 15.3 3.1 0.037 14.3 0.3 2.7 2 2 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 TPR_MalT PF17874.1 EKE42291.1 - 0.044 13.2 0.9 0.084 12.2 0.8 1.5 2 0 0 2 2 2 0 MalT-like TPR region LRR_5 PF13306.6 EKE42293.1 - 2.7e-74 247.2 45.5 3.4e-28 98.2 7.1 3.8 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE42293.1 - 6.6e-15 54.6 0.2 0.0069 16.1 0.0 6.6 2 2 5 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 EKE42293.1 - 0.015 15.7 9.2 0.4 11.2 0.4 5.6 3 2 1 5 5 5 0 Leucine Rich repeats (2 copies) Chitin_synth_1 PF01644.17 EKE42293.1 - 0.34 10.9 3.8 0.59 10.1 0.2 2.4 1 1 0 2 2 2 0 Chitin synthase Peptidase_M8 PF01457.16 EKE42293.1 - 0.38 9.4 12.0 0.97 8.0 0.2 3.3 3 0 0 3 3 3 0 Leishmanolysin RasGEF PF00617.19 EKE42294.1 - 4.7e-18 66.0 3.2 4.7e-18 66.0 3.2 2.2 2 1 1 3 3 3 1 RasGEF domain RasGEF_N PF00618.20 EKE42294.1 - 8.7e-08 32.4 3.8 1.5e-07 31.6 0.1 3.2 2 2 0 2 2 2 1 RasGEF N-terminal motif RCC1 PF00415.18 EKE42294.1 - 1.4e-05 25.6 0.1 0.00061 20.3 0.0 2.9 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EKE42294.1 - 9.4e-05 22.1 0.4 0.0007 19.3 0.0 2.7 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Palm_thioest PF02089.15 EKE42295.1 - 0.015 15.2 1.5 0.51 10.1 0.3 2.2 2 0 0 2 2 2 0 Palmitoyl protein thioesterase Taxilin PF09728.9 EKE42296.1 - 3.6 6.7 92.9 0.29 10.3 26.3 2.2 1 1 1 2 2 2 0 Myosin-like coiled-coil protein ATG16 PF08614.11 EKE42296.1 - 8.1 6.6 79.5 2 8.6 29.9 4.8 1 1 4 5 5 5 0 Autophagy protein 16 (ATG16) Chromo PF00385.24 EKE42297.1 - 6.2e-15 54.8 1.3 1.9e-14 53.3 1.3 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain POT1 PF02765.17 EKE42297.1 - 0.0035 17.2 0.3 0.042 13.7 0.1 2.3 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 Chromo_shadow PF01393.19 EKE42297.1 - 0.054 13.6 1.1 9.7 6.4 0.3 2.7 2 1 0 2 2 2 0 Chromo shadow domain Sigma_reg_N PF13800.6 EKE42298.1 - 0.0099 16.2 2.0 0.0099 16.2 2.0 3.6 1 1 3 4 4 4 1 Sigma factor regulator N-terminal DUF2070 PF09843.9 EKE42298.1 - 0.98 7.6 16.2 1.2 7.3 16.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Sdh_cyt PF01127.22 EKE42298.1 - 9.5 6.3 10.6 3.1 7.8 5.7 2.1 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Peptidase_C1 PF00112.23 EKE42299.1 - 7.5e-26 91.6 10.1 1.2e-25 90.9 10.1 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE42299.1 - 0.021 15.2 1.0 0.021 15.2 1.0 2.3 2 0 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) PP2C PF00481.21 EKE42300.1 - 9.8e-50 169.6 0.0 1.7e-49 168.8 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C YqbF PF14553.6 EKE42300.1 - 0.097 12.5 0.4 1.6 8.7 0.0 2.7 2 0 0 2 2 2 0 YqbF, hypothetical protein domain Kinesin PF00225.23 EKE42301.1 - 1.1e-24 87.1 5.5 1.1e-24 87.1 5.5 4.5 3 2 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EKE42301.1 - 1.1e-12 48.1 1.1 1.1e-12 48.1 1.1 5.1 5 1 0 5 5 5 1 Microtubule binding DUF885 PF05960.11 EKE42301.1 - 0.15 11.7 7.2 0.23 11.0 5.9 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Baculo_PEP_C PF04513.12 EKE42301.1 - 7.1 6.7 16.3 15 5.6 0.3 5.1 4 1 2 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus TLD PF07534.16 EKE42302.1 - 0.064 13.5 2.2 0.08 13.2 0.5 1.9 1 1 0 2 2 2 0 TLD DUF1298 PF06974.13 EKE42304.1 - 2.3e-27 95.7 0.0 4.4e-27 94.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) WES_acyltransf PF03007.16 EKE42304.1 - 1.1e-05 25.3 0.0 2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain AATase PF07247.12 EKE42304.1 - 0.0001 21.0 0.5 0.00018 20.2 0.5 1.6 1 1 0 1 1 1 1 Alcohol acetyltransferase DUF2262 PF10020.9 EKE42304.1 - 0.031 14.7 0.0 0.53 10.7 0.0 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2262) Raco_middle PF17651.1 EKE42305.1 - 0.036 13.8 1.2 0.059 13.0 0.1 2.0 1 1 1 2 2 2 0 RACo middle region LRR_4 PF12799.7 EKE42306.1 - 5.6e-09 36.1 32.1 5.3e-06 26.7 2.1 5.4 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE42306.1 - 9.9e-05 22.0 11.0 0.0029 17.3 0.5 4.6 4 1 1 5 5 5 2 Leucine rich repeat PDZ_2 PF13180.6 EKE42306.1 - 0.015 15.6 0.3 0.075 13.4 0.1 2.2 2 0 0 2 2 2 0 PDZ domain LRR_9 PF14580.6 EKE42306.1 - 0.61 9.6 17.5 0.13 11.7 5.6 3.4 2 1 1 3 3 3 0 Leucine-rich repeat UQ_con PF00179.26 EKE42307.1 - 9.6e-48 161.4 0.1 1.1e-47 161.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EKE42307.1 - 0.0098 15.6 0.0 0.017 14.8 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B Gag_p10 PF02337.17 EKE42308.1 - 0.12 12.3 0.0 1.2 9.2 0.0 2.5 2 0 0 2 2 2 0 Retroviral GAG p10 protein Pkinase PF00069.25 EKE42309.1 - 1.8e-51 175.0 0.0 3.5e-51 174.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42309.1 - 1.6e-49 168.5 0.0 2.9e-49 167.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE42309.1 - 7.3e-05 21.7 0.0 0.00012 21.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE42309.1 - 0.039 13.3 0.0 0.07 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HEAT PF02985.22 EKE42310.1 - 2.1e-17 61.7 4.9 0.032 14.5 0.0 7.8 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.6 EKE42310.1 - 3.7e-14 52.9 0.0 0.0033 17.8 0.0 4.6 1 1 4 5 5 5 5 HEAT repeats Cnd1 PF12717.7 EKE42310.1 - 1.5e-08 34.8 4.7 0.0078 16.3 0.1 4.0 1 1 3 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EKE42310.1 - 0.00011 20.9 4.3 0.01 14.4 0.1 2.7 1 1 1 2 2 2 2 Adaptin N terminal region HEAT_EZ PF13513.6 EKE42310.1 - 0.0058 17.1 6.7 6 7.5 0.1 5.3 4 2 1 5 5 5 1 HEAT-like repeat RTP1_C1 PF10363.9 EKE42310.1 - 0.14 12.4 1.6 45 4.3 0.4 3.4 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF4042 PF13251.6 EKE42310.1 - 0.37 10.5 3.0 4 7.1 0.2 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4042) Ras PF00071.22 EKE42311.1 - 1.1e-54 184.4 0.8 1.3e-54 184.1 0.8 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42311.1 - 5.7e-20 71.7 0.0 1.1e-19 70.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42311.1 - 3.5e-12 46.1 0.2 4.3e-12 45.8 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EKE42311.1 - 1e-06 28.8 3.2 0.00065 19.6 0.2 2.2 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EKE42311.1 - 5.5e-05 22.8 0.6 0.0002 21.0 0.3 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE42311.1 - 0.00018 21.6 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE42311.1 - 0.00044 19.7 0.2 0.00059 19.3 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EKE42311.1 - 0.0025 17.3 1.3 0.035 13.7 1.3 2.5 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EKE42311.1 - 0.0064 16.3 0.5 0.014 15.2 0.1 1.7 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1_Xtn PF16897.5 EKE42311.1 - 0.017 15.2 0.5 0.048 13.7 0.2 1.8 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain Hpr_kinase_C PF07475.12 EKE42311.1 - 0.072 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain ParA PF10609.9 EKE42311.1 - 0.095 12.1 0.4 0.16 11.4 0.4 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase PglD_N PF17836.1 EKE42311.1 - 0.096 13.3 0.2 4.7 7.9 0.0 2.6 2 0 0 2 2 2 0 PglD N-terminal domain CbiA PF01656.23 EKE42311.1 - 0.11 12.6 0.1 0.24 11.5 0.1 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Trp_syntA PF00290.20 EKE42312.1 - 0.017 14.0 0.1 5.3 5.8 0.0 2.8 2 1 1 3 3 3 0 Tryptophan synthase alpha chain Cation_ATPase PF13246.6 EKE42312.1 - 0.048 13.7 0.1 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Cation transport ATPase (P-type) ODR4-like PF14778.6 EKE42313.1 - 0.0019 17.3 0.1 0.0021 17.1 0.1 1.1 1 0 0 1 1 1 1 Olfactory receptor 4-like LMBR1 PF04791.16 EKE42314.1 - 0.0025 16.8 3.2 0.0028 16.7 3.2 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein ALMT PF11744.8 EKE42314.1 - 0.014 14.2 0.5 0.017 14.0 0.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Shisa PF13908.6 EKE42314.1 - 0.019 15.2 0.0 0.045 14.0 0.0 1.6 1 1 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF2956 PF11169.8 EKE42314.1 - 0.03 14.5 0.4 0.03 14.5 0.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2956) Connexin PF00029.19 EKE42314.1 - 0.048 13.4 0.6 0.058 13.1 0.6 1.2 1 0 0 1 1 1 0 Connexin Sec62 PF03839.16 EKE42314.1 - 0.49 9.9 5.3 0.63 9.5 5.3 1.3 1 1 0 1 1 1 0 Translocation protein Sec62 Orf78 PF06024.12 EKE42314.1 - 1.6 9.1 6.2 2.8 8.3 6.2 1.6 1 1 0 1 1 1 0 Orf78 (ac78) TLD PF07534.16 EKE42317.1 - 9e-08 32.4 0.7 2.3e-07 31.1 0.7 1.7 1 0 0 1 1 1 1 TLD CH PF00307.31 EKE42317.1 - 0.0004 20.5 5.5 0.25 11.6 0.5 3.8 3 1 0 3 3 3 2 Calponin homology (CH) domain S1 PF00575.23 EKE42318.1 - 3.4e-22 78.6 52.8 6.2e-08 32.9 1.5 12.3 10 1 2 12 12 12 8 S1 RNA binding domain S1_2 PF13509.6 EKE42318.1 - 0.0058 16.7 15.0 1.2 9.2 0.1 7.4 7 0 0 7 7 7 2 S1 domain GP57 PF17594.2 EKE42318.1 - 0.023 14.4 0.3 0.99 9.2 0.0 2.9 2 0 0 2 2 2 0 Phage Tail fiber assembly helper gene product 57 Nucleoside_tran PF01733.18 EKE42319.1 - 4.9e-15 55.7 23.1 4.9e-15 55.7 23.1 2.9 2 1 0 2 2 2 1 Nucleoside transporter MFS_1 PF07690.16 EKE42319.1 - 4.9e-07 29.0 46.7 1.7e-06 27.2 17.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DcpS_C PF11969.8 EKE42320.1 - 1.2e-23 83.7 1.8 2.5e-23 82.7 1.8 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 EKE42320.1 - 5.9e-05 23.8 0.6 5.9e-05 23.8 0.6 1.9 2 1 0 2 2 2 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DUF870 PF05912.11 EKE42320.1 - 0.0017 18.4 0.3 0.0034 17.4 0.3 1.4 1 0 0 1 1 1 1 Caenorhabditis elegans protein of unknown function (DUF870) SapB_1 PF05184.15 EKE42321.1 - 0.00014 21.8 0.5 0.00014 21.8 0.5 2.5 3 1 0 3 3 3 1 Saposin-like type B, region 1 Sipho_tail PF05709.11 EKE42321.1 - 0.12 11.8 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Phage tail protein Pkinase PF00069.25 EKE42322.1 - 1.5e-40 139.2 0.0 4e-40 137.8 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42322.1 - 5.8e-40 137.2 0.0 1e-39 136.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase MHC_II_beta PF00969.19 EKE42322.1 - 0.022 14.8 0.5 0.057 13.5 0.5 1.6 1 0 0 1 1 1 0 Class II histocompatibility antigen, beta domain Pkinase_fungal PF17667.1 EKE42322.1 - 0.036 12.8 0.0 0.077 11.8 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EKE42322.1 - 0.046 13.6 0.0 0.07 13.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EKE42322.1 - 0.077 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sa_NUDIX PF18167.1 EKE42322.1 - 0.12 12.1 5.4 0.44 10.3 0.3 2.4 2 0 0 2 2 2 0 SMODS-associated NUDIX domain DUF1829 PF08862.10 EKE42322.1 - 1.4 9.4 5.2 75 3.9 0.0 4.1 5 0 0 5 5 5 0 Domain of unknown function DUF1829 SNARE_assoc PF09335.11 EKE42323.1 - 1.2e-10 41.9 3.1 1.2e-10 41.9 3.1 1.7 2 0 0 2 2 2 1 SNARE associated Golgi protein SHP PF03579.13 EKE42323.1 - 0.039 13.9 0.5 0.039 13.9 0.5 3.4 4 0 0 4 4 4 0 Small hydrophobic protein Ion_trans_2 PF07885.16 EKE42323.1 - 5.6 7.0 14.4 0.75 9.8 8.0 2.7 2 1 0 2 2 2 0 Ion channel DEAD PF00270.29 EKE42324.1 - 1.1e-49 168.6 0.4 2.1e-49 167.6 0.4 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE42324.1 - 2.1e-28 98.9 0.8 3.5e-26 91.7 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EKE42324.1 - 2.3e-17 63.0 0.0 4.2e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EKE42324.1 - 5.9e-08 32.9 0.2 5.9e-08 32.9 0.2 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 EKE42324.1 - 0.14 11.4 4.9 0.57 9.4 4.9 2.0 1 1 0 1 1 1 0 SecA DEAD-like domain AAA_22 PF13401.6 EKE42324.1 - 0.19 12.0 1.2 0.89 9.8 0.8 2.4 2 1 0 2 2 2 0 AAA domain Tim54 PF11711.8 EKE42324.1 - 0.22 10.3 6.8 0.34 9.6 6.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ldh_2 PF02615.14 EKE42325.1 - 2.6e-108 362.1 0.0 2.9e-108 362.0 0.0 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Ribo_biogen_C PF04034.13 EKE42325.1 - 0.11 12.2 0.0 2.2 8.0 0.0 2.5 3 0 0 3 3 3 0 Ribosome biogenesis protein, C-terminal Pkinase_Tyr PF07714.17 EKE42326.1 - 1.1e-53 182.1 0.0 1.9e-53 181.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE42326.1 - 3.2e-46 157.8 0.0 5.8e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE42326.1 - 5.9e-05 22.0 0.4 5.9e-05 22.0 0.4 2.2 2 1 0 2 2 2 1 Fungal protein kinase PPC PF04151.15 EKE42326.1 - 0.022 15.9 0.7 0.022 15.9 0.7 2.2 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain ParE-like_toxin PF15781.5 EKE42327.1 - 0.11 12.5 0.1 1.6 8.7 0.0 2.2 2 0 0 2 2 2 0 ParE-like toxin of type II bacterial toxin-antitoxin system Med12-LCEWAV PF12145.8 EKE42328.1 - 0.045 12.6 4.8 0.057 12.3 4.8 1.2 1 0 0 1 1 1 0 Eukaryotic Mediator 12 subunit domain Glyco_hydro_42C PF08533.10 EKE42328.1 - 0.098 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Beta-galactosidase C-terminal domain DUF262 PF03235.14 EKE42328.1 - 1.4 9.0 9.4 2 8.5 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 Atg14 PF10186.9 EKE42328.1 - 1.7 7.6 11.2 2.6 7.1 11.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Proteasome PF00227.26 EKE42329.1 - 8.4e-52 175.4 0.1 1e-51 175.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EKE42329.1 - 6.3e-12 44.9 0.1 1.4e-11 43.9 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature NPV_P10 PF05531.12 EKE42329.1 - 0.043 14.3 2.7 2 8.9 1.6 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein V-SNARE_C PF12352.8 EKE42329.1 - 0.084 13.2 0.0 0.35 11.2 0.0 2.0 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus PAP2_C PF14360.6 EKE42330.1 - 3.8e-11 43.3 10.2 3.8e-11 43.3 10.2 3.8 3 2 1 4 4 4 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EKE42330.1 - 2.1e-06 27.5 6.2 2.1e-06 27.5 6.2 1.8 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EKE42330.1 - 0.19 11.4 10.2 0.12 12.1 3.1 2.4 2 1 0 2 2 2 0 PAP2 superfamily NPR3 PF03666.13 EKE42331.1 - 6.4e-23 81.3 8.0 2.1e-19 69.7 7.9 2.5 1 1 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 Spy1 PF11357.8 EKE42331.1 - 0.006 16.9 0.3 2.2 8.6 0.0 2.5 2 0 0 2 2 2 2 Cell cycle regulatory protein MetOD1 PF18546.1 EKE42331.1 - 0.18 11.8 0.1 0.18 11.8 0.1 2.1 3 0 0 3 3 3 0 Metanogen output domain 1 PCI PF01399.27 EKE42331.1 - 0.19 12.3 1.9 0.76 10.3 0.1 2.7 2 1 1 3 3 3 0 PCI domain HMG_box PF00505.19 EKE42332.1 - 4.7e-12 46.1 4.3 4.7e-12 46.1 4.3 2.5 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EKE42332.1 - 2.6e-07 31.1 5.2 2.6e-07 31.1 5.2 2.4 2 1 0 2 2 2 1 HMG-box domain Kinesin_assoc PF16183.5 EKE42332.1 - 0.038 14.1 4.2 0.035 14.3 3.2 1.4 1 1 0 1 1 1 0 Kinesin-associated A_thal_3526 PF09713.10 EKE42332.1 - 0.07 13.4 0.6 0.15 12.3 0.1 1.8 2 0 0 2 2 2 0 Plant protein 1589 of unknown function (A_thal_3526) RFamide_26RFa PF11109.8 EKE42332.1 - 0.93 10.0 5.5 0.5 10.9 1.1 2.3 1 1 1 2 2 2 0 Orexigenic neuropeptide Qrfp/P518 DUF3347 PF11827.8 EKE42332.1 - 6.1 7.0 14.9 8.3 6.6 14.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) DUF3332 PF11810.8 EKE42332.1 - 7.2 6.2 8.4 21 4.7 7.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3332) Ribosomal_L28 PF00830.19 EKE42333.1 - 0.011 16.0 1.9 0.021 15.0 1.9 1.6 1 1 0 1 1 1 0 Ribosomal L28 family DUF2894 PF11445.8 EKE42333.1 - 1.2 9.5 4.9 1.2 9.6 3.8 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2894) BRF1 PF07741.13 EKE42333.1 - 3.3 8.1 12.9 0.6 10.5 8.9 1.8 1 1 1 2 2 2 0 Brf1-like TBP-binding domain SPT2 PF08243.11 EKE42333.1 - 8.1 7.0 20.2 0.92 10.1 4.5 3.1 2 1 1 3 3 3 0 SPT2 chromatin protein tRNA-synt_1 PF00133.22 EKE42334.1 - 5.1e-224 745.0 0.1 7e-224 744.5 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EKE42334.1 - 7.2e-30 104.0 0.2 2.2e-29 102.4 0.1 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EKE42334.1 - 7.4e-14 51.3 0.5 0.00089 18.1 0.0 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EKE42334.1 - 0.0039 16.6 0.0 0.011 15.2 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain RRM_1 PF00076.22 EKE42335.1 - 2.1e-07 30.6 0.0 3.3e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_15 PF13175.6 EKE42336.1 - 7e-05 22.7 13.3 7e-05 22.7 13.3 2.1 1 1 1 2 2 2 1 AAA ATPase domain MRG PF05712.13 EKE42337.1 - 0.0072 15.7 0.3 0.011 15.1 0.3 1.4 1 0 0 1 1 1 1 MRG F-box PF00646.33 EKE42337.1 - 0.15 12.0 0.1 0.4 10.6 0.1 1.6 1 0 0 1 1 1 0 F-box domain MINDY_DUB PF04424.13 EKE42338.1 - 0.016 15.3 0.1 0.07 13.2 0.1 1.9 2 0 0 2 2 2 0 MINDY deubiquitinase Bromodomain PF00439.25 EKE42339.1 - 1.2e-21 76.5 2.0 2.1e-21 75.8 0.1 2.2 2 0 0 2 2 2 1 Bromodomain BET PF17035.5 EKE42339.1 - 3.2e-05 24.0 4.9 0.00013 22.1 4.9 2.1 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Myotub-related PF06602.14 EKE42340.1 - 4.7e-108 361.3 1.2 7.9e-108 360.5 1.2 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 EKE42340.1 - 0.0046 16.9 0.0 0.0079 16.2 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EKE42340.1 - 0.009 15.6 0.0 0.022 14.3 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Xpo1 PF08389.12 EKE42340.1 - 0.009 16.1 1.6 0.013 15.6 0.3 1.9 2 0 0 2 2 2 1 Exportin 1-like protein DSPc PF00782.20 EKE42340.1 - 0.013 15.3 0.0 0.038 13.8 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain HTH_29 PF13551.6 EKE42340.1 - 0.032 14.3 0.0 0.078 13.0 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix SMC_N PF02463.19 EKE42341.1 - 8e-25 87.6 39.8 4.9e-24 85.0 38.3 3.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EKE42341.1 - 1.1e-24 87.0 0.1 2.5e-24 85.8 0.1 1.7 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EKE42341.1 - 8.3e-07 29.0 27.2 8.3e-07 29.0 27.2 3.9 2 2 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EKE42341.1 - 4e-05 23.3 0.1 0.0001 21.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EKE42341.1 - 0.00012 22.0 0.4 0.00012 22.0 0.4 4.0 4 2 1 5 5 5 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 EKE42341.1 - 0.37 11.3 0.1 0.37 11.3 0.1 5.3 3 2 0 3 3 3 0 ABC transporter LacI PF00356.21 EKE42341.1 - 0.38 10.6 1.4 1.6 8.6 0.0 2.9 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family XhlA PF10779.9 EKE42342.1 - 0.015 15.5 2.8 0.015 15.5 2.8 10.7 9 2 2 11 11 11 0 Haemolysin XhlA YmaF PF12788.7 EKE42342.1 - 0.75 10.4 3.1 1 10.0 0.0 2.7 3 0 0 3 3 3 0 YmaF family Baculo_PEP_C PF04513.12 EKE42342.1 - 4 7.5 20.7 0.12 12.4 0.6 4.8 4 2 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Conotoxin PF02950.17 EKE42343.1 - 0.019 16.0 0.1 0.021 15.8 0.1 1.1 1 0 0 1 1 1 0 Conotoxin FAM176 PF14851.6 EKE42343.1 - 0.034 13.8 3.2 0.04 13.6 3.2 1.1 1 0 0 1 1 1 0 FAM176 family DUF4006 PF13179.6 EKE42343.1 - 0.16 11.9 0.0 0.22 11.5 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF4006) GRP PF07172.11 EKE42343.1 - 0.21 12.3 0.1 0.22 12.2 0.1 1.1 1 0 0 1 1 1 0 Glycine rich protein family TRAP_alpha PF03896.16 EKE42343.1 - 0.51 9.5 6.1 0.56 9.4 6.1 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Flavi_NS2B PF01002.19 EKE42343.1 - 0.57 10.0 1.9 0.63 9.9 1.9 1.0 1 0 0 1 1 1 0 Flavivirus non-structural protein NS2B Sporozoite_P67 PF05642.11 EKE42343.1 - 2.2 6.2 5.3 2.1 6.4 5.3 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MMS1_N PF10433.9 EKE42344.1 - 5.8e-98 328.6 2.4 5.8e-98 328.6 2.4 2.0 3 0 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EKE42344.1 - 2.1e-55 188.3 0.4 1.2e-51 176.0 0.0 2.9 3 0 0 3 3 3 2 CPSF A subunit region IF2_N PF04760.15 EKE42344.1 - 0.079 12.8 1.1 0.18 11.7 1.1 1.6 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region TLD PF07534.16 EKE42345.1 - 0.001 19.3 4.5 0.0024 18.1 4.5 1.6 1 0 0 1 1 1 1 TLD TLD PF07534.16 EKE42346.1 - 0.0063 16.7 0.2 0.012 15.8 0.2 1.6 1 0 0 1 1 1 1 TLD DUF5407 PF17401.2 EKE42346.1 - 0.18 12.1 1.2 0.37 11.1 1.2 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5407) RPN7 PF10602.9 EKE42347.1 - 0.08 12.6 0.1 0.08 12.6 0.1 1.1 1 0 0 1 1 1 0 26S proteasome subunit RPN7 SKICH PF17751.1 EKE42348.1 - 0.011 16.3 0.7 0.45 11.1 0.2 2.7 2 0 0 2 2 2 0 SKICH domain Macoilin PF09726.9 EKE42348.1 - 0.2 10.2 16.1 0.27 9.8 16.1 1.1 1 0 0 1 1 1 0 Macoilin family Peptidase_C1 PF00112.23 EKE42349.1 - 0.004 17.3 13.2 0.026 14.6 1.0 2.9 1 1 1 2 2 2 2 Papain family cysteine protease RecO_N_2 PF13114.6 EKE42349.1 - 0.047 13.4 0.1 0.16 11.7 0.1 1.9 1 0 0 1 1 1 0 RecO N terminal DUF1056 PF06341.11 EKE42349.1 - 0.42 11.0 2.9 0.37 11.1 1.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1056) RasGAP PF00616.19 EKE42350.1 - 3e-09 36.9 1.5 3e-09 36.9 1.5 3.3 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase MA3 PF02847.17 EKE42350.1 - 0.035 14.1 0.2 2.8 8.0 0.1 3.1 2 0 0 2 2 2 0 MA3 domain Lys-AminoMut_A PF09043.11 EKE42350.1 - 0.24 9.8 1.2 0.45 8.9 1.2 1.4 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit Dev_Cell_Death PF10539.9 EKE42352.1 - 0.039 13.8 0.2 1.1 9.2 0.1 2.0 1 1 1 2 2 2 0 Development and cell death domain Arm PF00514.23 EKE42353.1 - 2e-07 30.8 4.6 0.00015 21.7 0.1 3.7 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat RICTOR_V PF14668.6 EKE42353.1 - 0.011 16.0 0.3 0.043 14.1 0.1 2.2 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 CDC37_M PF08565.11 EKE42353.1 - 0.027 14.4 1.3 0.07 13.1 1.3 1.7 1 0 0 1 1 1 0 Cdc37 Hsp90 binding domain HEAT PF02985.22 EKE42353.1 - 0.04 14.2 0.1 0.34 11.3 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat Guanylin PF02058.15 EKE42353.1 - 0.14 12.7 0.4 0.41 11.2 0.4 1.9 1 0 0 1 1 1 0 Guanylin precursor SPRY PF00622.28 EKE42354.1 - 1.5e-08 34.8 0.2 3.8e-08 33.5 0.2 1.7 1 0 0 1 1 1 1 SPRY domain PBD PF00786.28 EKE42354.1 - 0.24 11.8 2.7 1.4 9.3 0.9 2.7 2 0 0 2 2 2 0 P21-Rho-binding domain YabA PF06156.13 EKE42354.1 - 2.1 9.0 9.8 2.1 9.0 7.6 2.2 2 0 0 2 2 2 0 Initiation control protein YabA Eaf7 PF07904.13 EKE42354.1 - 5.5 7.4 8.0 3.2 8.2 5.0 2.2 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 DUF2492 PF10678.9 EKE42355.1 - 0.056 13.7 0.9 0.24 11.7 0.9 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2492) Gcd10p PF04189.13 EKE42356.1 - 3.4e-36 124.9 0.7 4.8e-36 124.4 0.7 1.3 1 0 0 1 1 1 1 Gcd10p family HTH_51 PF18558.1 EKE42356.1 - 0.022 14.6 0.5 0.13 12.1 0.1 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain Glyco_transf_5 PF08323.11 EKE42357.1 - 4.6e-32 111.6 0.0 9.1e-32 110.7 0.0 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EKE42357.1 - 1.8e-12 47.1 0.0 4.5e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EKE42357.1 - 3.2e-08 34.1 0.0 8.5e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 DHC_N1 PF08385.12 EKE42357.1 - 0.00066 18.4 5.4 0.00078 18.2 0.3 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 Glyco_transf_4 PF13439.6 EKE42357.1 - 0.0048 16.9 0.0 0.022 14.8 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase Family 4 RasGEF PF00617.19 EKE42360.1 - 1.9e-17 64.0 0.9 4.9e-17 62.7 0.9 1.7 1 0 0 1 1 1 1 RasGEF domain Peptidase_C1 PF00112.23 EKE42363.1 - 1.8e-08 34.7 0.1 0.00074 19.7 0.1 2.3 2 0 0 2 2 2 2 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EKE42363.1 - 0.071 11.9 0.2 9.1 4.9 0.2 2.1 2 0 0 2 2 2 0 Peptidase C1-like family Ribophorin_I PF04597.14 EKE42364.1 - 1.8e-65 221.9 5.9 2.1e-65 221.7 5.9 1.0 1 0 0 1 1 1 1 Ribophorin I FemAB PF02388.16 EKE42364.1 - 0.081 11.8 0.3 0.12 11.2 0.3 1.2 1 0 0 1 1 1 0 FemAB family p25-alpha PF05517.12 EKE42365.1 - 0.11 12.7 0.8 0.2 11.8 0.8 1.4 1 0 0 1 1 1 0 p25-alpha TPR_1 PF00515.28 EKE42365.1 - 0.48 10.3 2.5 0.85 9.6 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat SIS PF01380.22 EKE42366.1 - 3.5e-36 123.9 4.7 1e-19 70.7 0.4 3.0 3 0 0 3 3 3 2 SIS domain GATase_6 PF13522.6 EKE42366.1 - 1.8e-18 67.0 0.0 3.6e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EKE42366.1 - 8.6e-13 48.3 0.0 1.9e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EKE42366.1 - 0.00017 20.6 0.0 0.00054 18.9 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferases class-II WBS_methylT PF12589.8 EKE42367.1 - 4.3e-17 62.6 6.5 7.1e-17 61.9 6.5 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EKE42367.1 - 5.4e-13 49.4 0.0 9.4e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE42367.1 - 2.3e-12 47.4 0.0 4.3e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EKE42367.1 - 1e-08 35.1 0.0 1.4e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKE42367.1 - 3.1e-06 27.1 0.0 6.4e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EKE42367.1 - 8.2e-05 23.3 0.0 0.0002 22.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EKE42367.1 - 0.00022 20.9 0.0 0.00041 20.0 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 EKE42367.1 - 0.026 14.1 0.0 0.047 13.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 EKE42367.1 - 0.03 14.1 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 EKE42367.1 - 0.039 14.0 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AviRa PF11599.8 EKE42367.1 - 0.039 13.4 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa RAB3GAP2_N PF14655.6 EKE42370.1 - 3.3e-07 29.9 0.6 2.1e-05 24.0 0.0 2.5 2 1 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus CPSF_A PF03178.15 EKE42371.1 - 3.2e-54 184.4 7.5 2.7e-53 181.4 1.4 3.3 4 0 0 4 4 4 2 CPSF A subunit region MMS1_N PF10433.9 EKE42371.1 - 3.3e-34 118.4 6.8 3.3e-34 118.4 6.8 1.8 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Vps39_2 PF10367.9 EKE42372.1 - 0.00067 20.1 3.2 0.0015 18.9 0.7 2.6 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 zf-C3H2C3 PF17122.5 EKE42372.1 - 0.0059 16.6 10.0 0.0059 16.6 10.0 2.1 2 0 0 2 2 2 1 Zinc-finger FPL PF09758.9 EKE42372.1 - 0.015 15.3 2.4 0.06 13.3 1.1 2.6 1 1 1 2 2 2 0 Uncharacterised conserved protein Amido_AtzD_TrzD PF09663.10 EKE42372.1 - 0.018 14.1 0.0 0.03 13.4 0.0 1.2 1 0 0 1 1 1 0 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD) Zn_ribbon_17 PF17120.5 EKE42372.1 - 0.44 10.2 5.4 1.2 8.8 5.4 1.8 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EKE42372.1 - 6.9 6.6 8.6 15 5.5 8.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FAS_N PF17828.1 EKE42373.1 - 0.02 14.9 1.3 0.02 14.9 1.3 1.9 2 0 0 2 2 2 0 N-terminal domain in fatty acid synthase subunit beta IF4E PF01652.18 EKE42375.1 - 3.8e-23 82.0 0.2 4.5e-23 81.8 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E TLD PF07534.16 EKE42376.1 - 2.1e-10 41.0 3.7 2.1e-10 41.0 3.7 1.3 1 1 0 1 1 1 1 TLD RasGEF PF00617.19 EKE42378.1 - 4.6e-11 43.2 3.4 4.6e-11 43.2 3.4 2.0 2 0 0 2 2 2 1 RasGEF domain Toxin_33 PF08121.11 EKE42378.1 - 0.18 11.6 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 Waglerin family PD40 PF07676.12 EKE42378.1 - 0.2 11.6 0.6 0.52 10.3 0.0 2.0 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat SAM_adeno_trans PF01887.16 EKE42379.1 - 2e-60 204.2 0.2 2.3e-60 204.0 0.2 1.0 1 0 0 1 1 1 1 S-adenosyl-l-methionine hydroxide adenosyltransferase DUF3887 PF13026.6 EKE42379.1 - 0.093 13.6 0.1 0.17 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3887) Methyltransf_15 PF09445.10 EKE42380.1 - 3.7e-26 91.7 0.1 5e-26 91.3 0.1 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 EKE42380.1 - 7e-07 29.2 0.0 8e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 EKE42380.1 - 1e-05 25.3 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 EKE42380.1 - 1.4e-05 24.9 0.0 1.6e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 EKE42380.1 - 0.00021 21.1 0.0 0.00027 20.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EKE42380.1 - 0.00027 21.6 0.0 0.00041 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TRM PF02005.16 EKE42380.1 - 0.0025 17.1 0.0 0.0032 16.7 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase MTS PF05175.14 EKE42380.1 - 0.0054 16.3 0.0 0.0071 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 EKE42380.1 - 0.0079 15.6 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltr_RsmB-F PF01189.17 EKE42380.1 - 0.052 13.2 0.0 0.073 12.7 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_11 PF08241.12 EKE42380.1 - 0.096 13.3 0.0 0.16 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Cupin_2 PF07883.11 EKE42381.1 - 5.2e-09 35.7 0.9 6.6e-09 35.4 0.9 1.1 1 0 0 1 1 1 1 Cupin domain RhoGAP PF00620.27 EKE42383.1 - 2.4e-36 124.9 0.1 5.1e-36 123.8 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain Glyco_hydro_85 PF03644.13 EKE42383.1 - 0.017 14.6 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 NUC173 PF08161.12 EKE42384.1 - 3.7e-17 62.7 16.4 9.2e-16 58.1 0.5 5.5 7 0 0 7 7 7 3 NUC173 domain Pilt PF15453.6 EKE42384.1 - 2 7.7 5.3 3.1 7.1 5.3 1.2 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions PAP2_C PF14360.6 EKE42385.1 - 2e-23 82.7 6.4 2e-23 82.7 6.4 2.5 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EKE42385.1 - 4.1e-05 23.4 6.6 4.1e-05 23.4 6.6 1.9 2 1 0 2 2 2 1 PAP2 superfamily Ras PF00071.22 EKE42386.1 - 3.6e-28 98.2 0.7 4.3e-28 98.0 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42386.1 - 5.3e-16 58.9 0.1 8.8e-16 58.2 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42386.1 - 1.1e-07 31.4 0.3 1.5e-07 31.0 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 EKE42386.1 - 1.2e-05 24.8 0.1 0.00094 18.7 0.1 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EKE42386.1 - 1.5e-05 25.0 0.1 2.7e-05 24.2 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EKE42386.1 - 0.0005 20.0 0.4 0.0012 18.9 0.2 1.6 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 EKE42386.1 - 0.00072 19.5 0.6 0.038 13.9 0.1 2.6 1 1 2 3 3 3 1 RsgA GTPase TniB PF05621.11 EKE42386.1 - 0.00095 18.6 0.1 0.7 9.3 0.0 2.1 1 1 1 2 2 2 2 Bacterial TniB protein PduV-EutP PF10662.9 EKE42386.1 - 0.0013 18.5 0.2 0.016 14.9 0.2 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 EKE42386.1 - 0.0059 16.2 0.1 1.7 8.1 0.1 2.3 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EKE42386.1 - 0.017 15.4 0.0 0.66 10.2 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 EKE42386.1 - 0.025 14.3 0.0 0.053 13.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain CdhD PF03599.16 EKE42386.1 - 0.026 13.2 0.0 0.039 12.7 0.0 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit AAA_14 PF13173.6 EKE42386.1 - 0.055 13.5 1.3 0.1 12.7 0.5 1.8 1 1 0 1 1 1 0 AAA domain Ank_2 PF12796.7 EKE42387.1 - 4.7e-28 97.6 3.4 1.3e-13 51.3 0.3 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE42387.1 - 1.7e-20 73.1 0.6 7.2e-12 45.6 0.0 4.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE42387.1 - 1.8e-16 59.9 0.6 1.6e-09 37.8 0.0 3.6 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EKE42387.1 - 6.7e-15 54.8 3.1 2.4e-06 27.7 0.0 4.0 3 1 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EKE42387.1 - 2.4e-13 49.0 2.7 7.4e-06 25.9 0.0 4.8 4 0 0 4 4 4 2 Ankyrin repeat Peptidase_M1 PF01433.20 EKE42389.1 - 4.6e-70 235.6 0.3 7.7e-70 234.9 0.3 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EKE42389.1 - 1.2e-45 156.4 0.0 1.6e-45 156.0 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EKE42389.1 - 9.2e-42 143.3 0.1 2.3e-41 142.0 0.0 1.7 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain HEAT_2 PF13646.6 EKE42389.1 - 0.0092 16.4 0.0 0.03 14.7 0.0 1.9 2 0 0 2 2 2 1 HEAT repeats Peptidase_M78 PF06114.13 EKE42389.1 - 0.052 13.5 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 IrrE N-terminal-like domain SprT-like PF10263.9 EKE42389.1 - 0.12 12.2 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 SprT-like family Peptidase_M61 PF05299.12 EKE42389.1 - 2.7 8.4 7.1 3.3 8.1 2.0 3.2 3 1 0 3 3 3 0 M61 glycyl aminopeptidase RNA_pol_L_2 PF13656.6 EKE42390.1 - 1.2e-24 85.9 0.0 1.3e-24 85.8 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EKE42390.1 - 2.5e-09 36.4 0.0 3e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RIBIOP_C PF04950.12 EKE42391.1 - 5.2e-77 259.1 0.0 5.2e-77 259.1 0.0 2.5 3 0 0 3 3 3 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EKE42391.1 - 0.0077 16.3 1.6 0.017 15.2 0.1 2.4 2 0 0 2 2 2 1 AARP2CN (NUC121) domain Pkinase PF00069.25 EKE42393.1 - 1.2e-68 231.4 0.4 1.5e-68 231.0 0.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42393.1 - 1.3e-39 136.0 0.1 2e-39 135.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EKE42393.1 - 3.4e-10 40.0 4.7 4.5e-09 36.4 0.3 2.9 2 0 0 2 2 2 1 POLO box duplicated region Pkinase_fungal PF17667.1 EKE42393.1 - 1.3e-06 27.5 0.3 4.4e-06 25.7 0.1 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EKE42393.1 - 2.8e-06 26.9 0.1 0.00013 21.4 0.0 2.2 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EKE42393.1 - 0.0046 16.6 0.3 0.0097 15.5 0.3 1.5 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 EKE42393.1 - 0.12 12.0 0.8 3.9 7.0 0.1 2.4 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EKE42393.1 - 0.17 11.2 0.3 0.3 10.4 0.3 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DHHC PF01529.20 EKE42395.1 - 5.6e-24 84.8 25.8 5.6e-24 84.8 25.8 2.5 1 1 1 2 2 2 1 DHHC palmitoyltransferase Ndc1_Nup PF09531.10 EKE42396.1 - 0.11 11.1 15.5 0.16 10.6 15.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FliJ PF02050.16 EKE42397.1 - 0.69 10.1 6.3 0.25 11.6 0.5 2.6 2 1 0 2 2 2 0 Flagellar FliJ protein Pribosyltran_N PF13793.6 EKE42398.1 - 6.2e-16 58.4 0.0 2.1e-14 53.4 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EKE42398.1 - 1.5e-14 54.5 0.5 2.8e-14 53.6 0.5 1.4 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EKE42398.1 - 1.4e-11 44.2 0.0 3e-09 36.6 0.0 2.2 2 0 0 2 2 2 2 Phosphoribosyl transferase domain UPRTase PF14681.6 EKE42398.1 - 0.013 14.9 0.3 0.043 13.3 0.1 1.8 1 1 1 2 2 2 0 Uracil phosphoribosyltransferase V_ATPase_I PF01496.19 EKE42399.1 - 4.2e-82 276.4 3.8 1.8e-80 271.0 3.8 2.0 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family Vac_Fusion PF02346.16 EKE42399.1 - 0.011 15.3 0.1 0.038 13.6 0.1 2.0 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 Cep57_CLD PF14073.6 EKE42399.1 - 0.12 12.4 5.2 0.2 11.7 5.2 1.2 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 PCRF PF03462.18 EKE42399.1 - 0.63 9.9 2.8 1.2 9.0 2.8 1.4 1 0 0 1 1 1 0 PCRF domain ArfGap PF01412.18 EKE42400.1 - 9.1e-33 112.8 0.4 9.1e-33 112.8 0.4 1.9 2 1 0 2 2 2 1 Putative GTPase activating protein for Arf IKBKB_SDD PF18397.1 EKE42400.1 - 0.038 13.3 0.1 0.059 12.7 0.1 1.3 1 0 0 1 1 1 0 IQBAL scaffold dimerization domain Pkinase PF00069.25 EKE42402.1 - 2e-72 243.8 0.1 2.3e-72 243.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42402.1 - 7.2e-36 123.8 0.0 9.2e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE42402.1 - 3.1e-08 33.3 0.0 4.4e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.24 EKE42402.1 - 1.7e-06 28.6 1.0 3.8e-06 27.5 1.0 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EKE42402.1 - 0.00033 19.7 0.3 0.00051 19.1 0.3 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EKE42402.1 - 0.047 12.5 0.0 0.087 11.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 EKE42402.1 - 0.048 13.2 0.1 0.097 12.3 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 EKE42402.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EKE42403.1 - 3.8e-51 174.0 1.5 9.5e-51 172.7 1.5 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42403.1 - 7.4e-23 81.1 0.1 1.2e-22 80.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EKE42403.1 - 0.00017 21.3 1.0 0.00017 21.3 1.0 3.0 2 1 1 3 3 3 1 Choline/ethanolamine kinase DUF4932 PF16286.5 EKE42403.1 - 0.0021 17.4 0.2 0.0039 16.5 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4932) Hemocyanin_M PF00372.19 EKE42403.1 - 0.017 14.3 0.1 0.12 11.5 0.1 2.1 2 0 0 2 2 2 0 Hemocyanin, copper containing domain Pkinase_fungal PF17667.1 EKE42403.1 - 0.11 11.3 0.1 0.17 10.6 0.1 1.4 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EKE42403.1 - 0.13 11.9 0.6 6.9 6.2 0.2 2.5 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RR_TM4-6 PF06459.12 EKE42403.1 - 0.2 11.5 2.0 6.5 6.5 0.0 2.9 3 0 0 3 3 3 0 Ryanodine Receptor TM 4-6 KH_6 PF15985.5 EKE42405.1 - 1.3e-13 51.1 0.3 1.7e-13 50.6 0.3 1.2 1 0 0 1 1 1 1 KH domain Pkinase_Tyr PF07714.17 EKE42406.1 - 5.7e-30 104.5 0.6 8.9e-30 103.8 0.6 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE42406.1 - 1.6e-24 86.7 1.8 2.5e-24 86.1 1.8 1.3 1 0 0 1 1 1 1 Protein kinase domain ANF_receptor PF01094.28 EKE42406.1 - 0.01 14.9 0.1 0.047 12.8 0.1 2.1 1 1 1 2 2 2 0 Receptor family ligand binding region Kinase-like PF14531.6 EKE42406.1 - 0.011 15.0 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Catalase_C PF18011.1 EKE42406.1 - 0.051 13.2 0.1 0.64 9.6 0.0 2.6 3 0 0 3 3 3 0 C-terminal domain found in long catalases HSF_DNA-bind PF00447.17 EKE42407.1 - 2.9e-22 79.1 3.5 4.7e-22 78.4 0.1 2.2 2 1 0 2 2 2 1 HSF-type DNA-binding DUF1664 PF07889.12 EKE42407.1 - 0.0018 18.3 0.5 0.0025 17.9 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) DUF1580 PF07618.11 EKE42407.1 - 0.031 13.9 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) Baculo_PEP_C PF04513.12 EKE42407.1 - 0.059 13.4 0.3 0.081 13.0 0.3 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus SlyX PF04102.12 EKE42407.1 - 0.12 13.0 3.6 0.12 13.1 2.4 1.6 1 1 0 1 1 1 0 SlyX DUF2730 PF10805.8 EKE42407.1 - 0.14 12.3 1.4 0.22 11.6 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) CorA PF01544.18 EKE42407.1 - 0.18 11.1 2.3 0.26 10.6 2.3 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Tubulin PF00091.25 EKE42408.1 - 1.2e-66 224.7 0.0 2.2e-66 223.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EKE42408.1 - 5e-38 130.1 0.1 9.9e-38 129.1 0.1 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 EKE42408.1 - 0.0011 18.2 0.0 0.0062 15.8 0.0 2.0 2 0 0 2 2 2 1 Tubulin like Misat_Tub_SegII PF10644.9 EKE42408.1 - 0.05 13.9 0.0 0.14 12.4 0.0 1.9 1 1 0 1 1 1 0 Misato Segment II tubulin-like domain Peptidase_S24 PF00717.23 EKE42409.1 - 5.6e-09 35.8 0.6 9.7e-09 35.1 0.6 1.4 1 0 0 1 1 1 1 Peptidase S24-like S10_plectin PF03501.15 EKE42410.1 - 7.2e-33 112.5 0.0 1.1e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 Plectin/S10 domain WD40_like PF17005.5 EKE42411.1 - 6.2e-07 29.0 1.0 6.2e-07 29.0 1.0 2.3 2 0 0 2 2 2 1 WD40-like domain DUF2935 PF11155.8 EKE42411.1 - 0.00021 21.6 3.3 1.4 9.3 0.0 3.8 2 1 2 4 4 4 1 Domain of unknown function (DUF2935) C1_1 PF00130.22 EKE42411.1 - 0.002 18.0 5.3 0.0045 16.8 5.3 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Atg14 PF10186.9 EKE42411.1 - 0.003 16.7 30.3 0.01 15.0 10.8 2.5 2 0 0 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_TATA_bd PF12325.8 EKE42411.1 - 0.0054 16.9 9.3 0.0054 16.9 9.3 3.8 3 1 1 4 4 3 1 TATA element modulatory factor 1 TATA binding PHD PF00628.29 EKE42411.1 - 0.091 12.7 5.5 0.25 11.3 5.5 1.8 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 EKE42411.1 - 0.54 9.9 4.4 1.2 8.8 4.4 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EKE42411.1 - 0.94 9.8 6.2 2.2 8.6 6.2 1.7 1 0 0 1 1 1 0 RING-like domain FPP PF05911.11 EKE42411.1 - 1.3 7.1 43.4 0.014 13.6 23.0 2.2 2 0 0 2 2 2 0 Filament-like plant protein, long coiled-coil SRR PF07709.11 EKE42411.1 - 2.3 9.0 4.6 8 7.3 0.5 3.0 2 0 0 2 2 2 0 Seven Residue Repeat ATG16 PF08614.11 EKE42411.1 - 5.9 7.1 38.7 4.1 7.6 17.8 2.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) HALZ PF02183.18 EKE42411.1 - 6.3 7.1 27.4 0.058 13.6 4.6 5.4 5 0 0 5 5 5 0 Homeobox associated leucine zipper FapA PF03961.13 EKE42411.1 - 6.7 5.2 37.1 0.47 9.0 12.9 2.7 1 1 0 2 2 2 0 Flagellar Assembly Protein A MCU PF04678.13 EKE42411.1 - 6.9 6.7 12.3 7.2 6.7 0.8 2.6 2 0 0 2 2 2 0 Mitochondrial calcium uniporter Mod_r PF07200.13 EKE42411.1 - 7.8 6.6 37.9 0.083 13.0 9.5 4.0 2 2 2 4 4 4 0 Modifier of rudimentary (Mod(r)) protein Spc7 PF08317.11 EKE42411.1 - 8.8 5.1 33.9 0.53 9.1 7.7 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein DnaJ PF00226.31 EKE42412.1 - 9.6e-23 80.1 4.2 2.1e-22 79.0 4.2 1.6 1 0 0 1 1 1 1 DnaJ domain DUF4337 PF14235.6 EKE42412.1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Metallophos PF00149.28 EKE42413.1 - 2.4e-10 41.3 0.2 3.8e-10 40.6 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE42413.1 - 1.6e-08 34.9 0.0 5e-08 33.3 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EKE42413.1 - 0.011 15.1 0.0 0.6 9.4 0.0 2.1 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily DUF3719 PF12516.8 EKE42413.1 - 0.17 11.6 0.1 0.6 9.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3719) Steroid_dh PF02544.16 EKE42414.1 - 3.6e-41 140.6 4.9 3.6e-41 140.6 4.9 2.0 2 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EKE42414.1 - 4.8e-06 26.3 0.5 1.1e-05 25.0 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EKE42414.1 - 0.0067 16.8 0.5 0.0067 16.8 0.5 2.9 2 2 1 3 3 3 1 Phospholipid methyltransferase DUF3437 PF11919.8 EKE42415.1 - 0.00089 19.1 0.0 0.0024 17.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) NOG1_N PF17835.1 EKE42417.1 - 6.7 6.7 11.5 0.053 13.5 1.4 2.5 3 0 0 3 3 3 0 NOG1 N-terminal helical domain VPS9 PF02204.18 EKE42419.1 - 2.1e-07 31.1 0.5 5.4e-07 29.8 0.0 1.9 2 1 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain TetR_C_8 PF14278.6 EKE42419.1 - 0.2 11.8 3.1 2.4 8.3 0.3 3.0 3 0 0 3 3 3 0 Transcriptional regulator C-terminal region DUF3232 PF11554.8 EKE42419.1 - 0.47 10.8 5.2 0.39 11.1 0.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3232) Pyr_redox_2 PF07992.14 EKE42420.1 - 8.1e-49 166.4 0.0 1.2e-48 165.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EKE42420.1 - 2.5e-17 63.2 2.5 2.1e-13 50.6 0.1 3.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EKE42420.1 - 2.2e-12 46.9 0.0 1.7e-11 44.0 0.0 2.0 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EKE42420.1 - 7.2e-12 45.1 0.0 2.3e-09 36.9 0.0 2.1 1 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EKE42420.1 - 1.2e-07 31.7 0.1 0.0011 18.6 0.1 3.4 3 1 1 4 4 4 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EKE42420.1 - 6.1e-06 26.4 0.2 0.0047 17.1 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EKE42420.1 - 0.00022 20.4 0.8 0.49 9.4 0.1 3.1 2 1 1 3 3 3 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 EKE42420.1 - 0.0041 17.1 0.6 0.48 10.4 0.1 3.2 3 1 1 4 4 4 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EKE42420.1 - 0.0041 16.4 0.1 0.64 9.2 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain DUF1188 PF06690.11 EKE42420.1 - 0.0049 16.5 0.2 0.02 14.4 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1188) Shikimate_DH PF01488.20 EKE42420.1 - 0.0059 16.7 0.4 3.1 7.8 0.0 2.3 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 EKE42420.1 - 0.0095 14.7 9.9 1.1 7.9 0.0 4.4 3 1 2 5 5 5 3 HI0933-like protein NAD_binding_7 PF13241.6 EKE42420.1 - 0.02 15.3 0.1 2.9 8.4 0.0 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 EKE42420.1 - 0.063 13.2 0.3 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EKE42420.1 - 0.065 12.5 1.0 10 5.4 0.0 2.9 2 1 1 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EKE42420.1 - 0.15 11.1 2.4 0.81 8.7 0.0 2.9 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EKE42420.1 - 0.21 10.6 2.5 16 4.4 0.0 3.0 3 0 0 3 3 3 0 FAD binding domain Cofilin_ADF PF00241.20 EKE42421.1 - 2.3e-26 92.0 0.0 2.6e-26 91.8 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein C2 PF00168.30 EKE42422.1 - 6e-08 32.9 0.0 7.8e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 C2 domain DUF5609 PF18429.1 EKE42424.1 - 0.058 13.2 0.1 0.86 9.4 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5609) LRR_5 PF13306.6 EKE42425.1 - 6.3e-38 129.6 26.1 3.6e-19 69.0 3.7 3.6 3 1 1 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE42425.1 - 1.1e-11 44.3 9.6 0.00035 20.3 0.3 4.3 2 1 2 4 4 4 3 Leucine rich repeat IQ_SEC7_PH PF16453.5 EKE42425.1 - 0.15 12.1 2.5 4.2 7.4 0.1 3.2 3 0 0 3 3 3 0 PH domain VHS PF00790.19 EKE42427.1 - 0.00049 20.0 0.5 0.0019 18.1 0.1 2.1 1 1 0 1 1 1 1 VHS domain ENTH PF01417.20 EKE42427.1 - 0.017 15.2 0.3 0.048 13.7 0.3 1.7 1 0 0 1 1 1 0 ENTH domain Haem_bd PF14376.6 EKE42427.1 - 0.03 14.3 0.3 0.066 13.2 0.3 1.5 1 0 0 1 1 1 0 Haem-binding domain CTD_bind PF04818.13 EKE42427.1 - 0.033 15.0 0.0 0.092 13.6 0.0 1.8 1 0 0 1 1 1 0 RNA polymerase II-binding domain. XLF PF09302.11 EKE42427.1 - 0.063 13.4 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DpnI_C PF17726.1 EKE42427.1 - 0.081 13.1 0.1 15 5.8 0.0 2.6 2 0 0 2 2 2 0 Dam-replacing HTH domain DUF676 PF05057.14 EKE42427.1 - 0.17 11.4 0.4 0.47 9.9 0.1 1.7 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Nsp1_C PF05064.13 EKE42428.1 - 0.019 14.7 0.3 0.031 14.1 0.3 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region DUF3090 PF11290.8 EKE42428.1 - 0.044 13.6 0.1 0.2 11.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3090) CCDC84 PF14968.6 EKE42428.1 - 0.09 12.4 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 Plk4_PB2 PF18409.1 EKE42428.1 - 0.098 13.3 0.2 0.56 10.9 0.1 1.9 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 RabGAP-TBC PF00566.18 EKE42429.1 - 3.8e-24 85.5 6.0 9.7e-24 84.2 6.0 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Rho_N PF07498.12 EKE42429.1 - 0.087 12.8 0.0 0.75 9.8 0.0 2.3 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain DUF1765 PF08578.10 EKE42431.1 - 9.3e-14 52.0 9.1 9.3e-14 52.0 9.1 1.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1765) Memo PF01875.17 EKE42431.1 - 0.038 13.1 0.1 0.1 11.7 0.1 1.6 1 1 0 1 1 1 0 Memo-like protein Pkinase PF00069.25 EKE42432.1 - 3.8e-75 252.7 0.4 5.4e-54 183.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42432.1 - 3.2e-50 170.8 0.0 3.1e-34 118.4 0.0 2.3 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE42432.1 - 0.013 14.3 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EKE42432.1 - 0.072 13.0 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_4 PF12799.7 EKE42433.1 - 5.2e-06 26.7 20.0 0.0017 18.7 1.9 4.4 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE42433.1 - 7.1e-05 22.5 14.8 0.0047 16.7 4.0 3.7 1 1 2 3 3 3 3 Leucine rich repeat TrmB PF01978.19 EKE42434.1 - 0.096 12.6 1.7 1.2 9.1 0.2 3.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Aminotran_1_2 PF00155.21 EKE42435.1 - 4.9e-34 118.1 0.0 5.9e-34 117.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EKE42435.1 - 2e-05 23.3 0.0 2.9e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EKE42435.1 - 0.00073 18.6 0.0 0.015 14.3 0.0 2.1 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_3 PF00202.21 EKE42435.1 - 0.00099 17.9 0.0 0.0014 17.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EKE42435.1 - 0.025 13.9 0.0 0.038 13.3 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase DHR-2 PF06920.13 EKE42436.1 - 6e-61 206.7 27.0 6e-61 206.7 27.0 2.7 3 0 0 3 3 3 1 Dock homology region 2 DUF5391 PF17369.2 EKE42436.1 - 0.12 12.4 4.5 0.079 13.0 1.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5391) FtsJ PF01728.19 EKE42437.1 - 4.9e-62 209.2 0.0 5.7e-62 209.0 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 EKE42437.1 - 0.037 13.7 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Ubie_methyltran PF01209.18 EKE42437.1 - 0.076 12.3 0.0 0.15 11.3 0.0 1.4 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EKE42437.1 - 0.094 12.6 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EKE42437.1 - 0.12 13.1 0.0 0.71 10.6 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain TLD PF07534.16 EKE42438.1 - 0.043 14.0 1.7 0.055 13.7 0.7 1.9 2 1 0 2 2 2 0 TLD G-patch PF01585.23 EKE42440.1 - 3e-07 30.2 1.0 5.8e-07 29.3 1.0 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EKE42440.1 - 2.1e-05 24.5 0.2 6e-05 23.0 0.1 1.8 1 1 0 1 1 1 1 G-patch domain DXPR_C PF13288.6 EKE42440.1 - 0.086 13.1 2.9 3.8 7.8 0.2 3.2 2 1 1 3 3 3 0 DXP reductoisomerase C-terminal domain Acetyltransf_11 PF13720.6 EKE42440.1 - 0.19 12.2 2.5 0.22 12.0 0.1 2.4 2 1 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 RasGEF PF00617.19 EKE42441.1 - 2.6e-27 96.2 0.8 2.6e-27 96.2 0.8 2.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EKE42441.1 - 0.0037 17.5 0.8 0.0037 17.5 0.8 3.4 4 0 0 4 4 4 1 RasGEF N-terminal motif TTRAP PF14203.6 EKE42441.1 - 0.24 11.4 3.5 20 5.3 0.0 3.7 4 0 0 4 4 4 0 Putative tranposon-transfer assisting protein Tetraspanin PF00335.20 EKE42443.1 - 0.0013 18.5 22.6 0.0033 17.2 22.6 1.6 1 1 0 1 1 1 1 Tetraspanin family LtrA PF06772.11 EKE42443.1 - 0.018 14.3 7.4 0.024 13.9 4.7 1.9 2 0 0 2 2 2 0 Bacterial low temperature requirement A protein (LtrA) Neurensin PF14927.6 EKE42443.1 - 1.7 8.4 11.0 22 4.8 0.1 2.6 2 1 0 2 2 2 0 Neurensin WD40 PF00400.32 EKE42444.1 - 2.9e-19 69.1 17.6 2.6e-07 31.2 0.1 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE42444.1 - 0.00023 21.4 0.0 1.2 9.4 0.0 3.2 2 1 1 3 3 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EKE42444.1 - 0.00033 20.1 0.7 0.016 14.5 0.0 3.0 3 1 1 4 4 4 2 WD40-like domain ATG16 PF08614.11 EKE42444.1 - 0.0042 17.3 11.8 0.0042 17.3 11.8 1.7 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) I_LWEQ PF01608.17 EKE42444.1 - 0.15 12.3 4.7 0.32 11.2 4.7 1.5 1 0 0 1 1 1 0 I/LWEQ domain DUF4200 PF13863.6 EKE42444.1 - 0.54 10.7 16.4 1.6 9.2 11.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Spore_III_AB PF09548.10 EKE42444.1 - 0.59 10.2 3.3 0.42 10.7 1.0 1.9 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) V_ATPase_I PF01496.19 EKE42444.1 - 0.83 7.5 7.6 1.1 7.0 7.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ADIP PF11559.8 EKE42444.1 - 1.1 9.3 16.7 6.1 6.9 3.5 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Mt_ATP-synt_D PF05873.12 EKE42444.1 - 1.6 8.6 7.9 0.92 9.3 5.5 1.7 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) TMPIT PF07851.13 EKE42444.1 - 1.7 7.8 8.3 3.4 6.8 8.3 1.4 1 0 0 1 1 1 0 TMPIT-like protein Tropomyosin_1 PF12718.7 EKE42444.1 - 1.7 8.8 15.7 3.9 7.6 15.7 1.5 1 1 0 1 1 1 0 Tropomyosin like HIP1_clath_bdg PF16515.5 EKE42444.1 - 2.2 9.0 11.3 1.2 9.8 8.9 1.8 2 0 0 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 EKE42444.1 - 3.1 8.5 10.3 0.38 11.4 4.1 2.4 1 1 1 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 EKE42444.1 - 4.5 6.5 12.2 3.4 6.9 2.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Golgin_A5 PF09787.9 EKE42444.1 - 5.5 6.4 17.5 33 3.8 16.7 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 Nsp1_C PF05064.13 EKE42444.1 - 7.9 6.3 12.0 6.5 6.6 8.8 2.3 1 1 1 2 2 2 0 Nsp1-like C-terminal region Thioredoxin PF00085.20 EKE42445.1 - 1.5e-07 31.3 0.5 5.8e-06 26.2 0.0 3.3 4 0 0 4 4 4 1 Thioredoxin Thioredoxin_8 PF13905.6 EKE42445.1 - 0.17 12.2 5.3 1.6 9.1 0.2 3.6 3 0 0 3 3 3 0 Thioredoxin-like DIM1 PF02966.16 EKE42445.1 - 0.31 10.8 3.1 0.31 10.8 0.6 2.3 2 0 0 2 2 2 0 Mitosis protein DIM1 DDOST_48kD PF03345.14 EKE42446.1 - 9.5e-94 314.6 7.2 1.1e-93 314.4 7.2 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta DUF5484 PF17583.2 EKE42446.1 - 0.032 13.9 0.1 0.18 11.5 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5484) ArfGap PF01412.18 EKE42447.1 - 8e-32 109.8 0.4 8e-32 109.8 0.4 1.7 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Mucin PF01456.17 EKE42447.1 - 0.0011 19.0 1.7 0.0015 18.5 1.7 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein DZR PF12773.7 EKE42447.1 - 0.062 13.3 0.5 0.17 11.9 0.5 1.7 1 0 0 1 1 1 0 Double zinc ribbon CAF20 PF17052.5 EKE42447.1 - 0.41 10.8 5.7 2.7 8.1 5.9 2.1 1 1 0 1 1 1 0 Cap associated factor zinc_ribbon_2 PF13240.6 EKE42447.1 - 3.2 7.6 7.0 0.29 10.9 2.0 1.9 2 0 0 2 2 2 0 zinc-ribbon domain PNK3P PF08645.11 EKE42448.1 - 0.36 10.5 8.2 0.21 11.3 0.6 3.1 3 0 0 3 3 3 0 Polynucleotide kinase 3 phosphatase DWNN PF08783.11 EKE42448.1 - 5.1 7.5 8.9 0.75 10.1 0.5 3.7 3 0 0 3 3 3 0 DWNN domain LPP20 PF02169.16 EKE42448.1 - 8.4 6.8 9.0 8.2 6.9 0.3 3.8 4 0 0 4 4 4 0 LPP20 lipoprotein RrnaAD PF00398.20 EKE42449.1 - 4.7e-63 212.7 0.1 5.9e-63 212.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EKE42449.1 - 3.8e-08 33.9 0.0 8.8e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKE42449.1 - 3e-05 24.6 0.0 6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EKE42449.1 - 0.00017 22.3 0.0 0.00045 20.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EKE42449.1 - 0.00049 20.0 0.0 0.00076 19.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EKE42449.1 - 0.0013 18.3 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 Nodulation protein S (NodS) PCMT PF01135.19 EKE42449.1 - 0.0021 17.9 0.0 0.0033 17.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.12 EKE42449.1 - 0.0025 17.0 0.0 0.0038 16.4 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_31 PF13847.6 EKE42449.1 - 0.0041 16.9 0.0 0.0088 15.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 EKE42449.1 - 0.027 14.3 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase MTS PF05175.14 EKE42449.1 - 0.036 13.6 0.0 0.08 12.5 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_4 PF02390.17 EKE42449.1 - 0.051 13.0 0.0 0.09 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_2 PF00891.18 EKE42449.1 - 0.052 12.8 0.0 0.082 12.2 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain UPF0020 PF01170.18 EKE42449.1 - 0.094 12.4 0.0 0.26 10.9 0.0 1.5 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.10 EKE42449.1 - 0.15 11.6 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_28 PF02636.17 EKE42449.1 - 0.2 11.3 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase SMK-1 PF04802.15 EKE42450.1 - 1.5e-11 44.5 7.6 1.5e-11 44.5 7.6 1.8 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 RIX1 PF08167.12 EKE42450.1 - 0.25 11.0 6.6 0.12 12.1 1.2 2.9 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis Piezo_RRas_bdg PF12166.8 EKE42451.1 - 1.9e-78 264.6 2.8 1.9e-78 264.6 2.8 2.2 3 0 0 3 3 3 1 Piezo non-specific cation channel, R-Ras-binding domain SH3_2 PF07653.17 EKE42451.1 - 0.0015 18.2 0.0 0.0034 17.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Holin_SPP1 PF04688.13 EKE42451.1 - 0.2 11.8 5.9 1.4 9.2 0.4 3.6 2 0 0 2 2 2 0 SPP1 phage holin Arf PF00025.21 EKE42452.1 - 2.6e-61 206.1 0.2 2.8e-61 206.0 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EKE42452.1 - 7.1e-14 52.1 0.1 1.8e-13 50.7 0.0 1.6 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EKE42452.1 - 2.3e-12 46.8 0.1 2.6e-12 46.6 0.1 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EKE42452.1 - 8.9e-09 35.0 0.0 1.1e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EKE42452.1 - 2e-08 33.8 1.1 4.5e-07 29.3 0.1 2.5 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EKE42452.1 - 6.7e-08 32.2 0.1 8.9e-08 31.8 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EKE42452.1 - 0.00077 19.5 0.0 0.0019 18.3 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase MeaB PF03308.16 EKE42452.1 - 0.036 13.1 0.1 0.049 12.6 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EKE42452.1 - 0.077 13.5 1.5 0.45 11.0 1.5 1.9 1 1 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 EKE42452.1 - 0.086 12.9 0.2 0.24 11.5 0.2 1.9 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.25 EKE42453.1 - 2.7e-82 276.1 0.0 3.5e-82 275.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42453.1 - 8.1e-49 166.2 0.4 1.8e-48 165.1 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase C2 PF00168.30 EKE42453.1 - 4.4e-11 43.0 0.6 4.1e-10 39.9 0.0 2.3 1 1 1 2 2 2 1 C2 domain Kinase-like PF14531.6 EKE42453.1 - 4.3e-05 23.0 0.0 0.007 15.7 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 EKE42453.1 - 0.0069 16.3 0.0 0.56 10.1 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family DUF4217 PF13959.6 EKE42455.1 - 2.8e-09 37.1 0.0 6.3e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) DEAD PF00270.29 EKE42455.1 - 0.0026 17.6 0.1 0.036 13.8 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase KilA-N PF04383.13 EKE42455.1 - 0.03 14.2 0.8 0.13 12.2 0.1 2.5 2 0 0 2 2 2 0 KilA-N domain Helicase_C PF00271.31 EKE42455.1 - 0.095 13.1 0.6 0.66 10.3 0.2 2.5 2 0 0 2 2 2 0 Helicase conserved C-terminal domain K-box PF01486.17 EKE42455.1 - 0.2 11.8 4.9 0.23 11.6 1.3 2.6 2 0 0 2 2 2 0 K-box region Ras PF00071.22 EKE42456.1 - 3.5e-50 169.8 1.1 5.4e-50 169.2 1.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42456.1 - 1.7e-28 99.2 0.2 5.4e-28 97.6 0.2 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42456.1 - 2.8e-13 49.7 0.2 6.2e-13 48.6 0.2 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE42456.1 - 0.00028 20.4 0.1 0.00028 20.4 0.1 2.4 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE42456.1 - 0.00063 19.7 7.6 0.014 15.3 0.5 2.8 3 1 0 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE42456.1 - 0.00076 19.5 0.5 0.0024 17.9 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EKE42456.1 - 0.0013 19.2 0.1 0.0053 17.2 0.0 2.1 2 1 1 3 3 3 1 AAA ATPase domain Gtr1_RagA PF04670.12 EKE42456.1 - 0.0016 17.9 0.5 0.0035 16.7 0.5 1.6 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 EKE42456.1 - 0.015 15.0 0.0 0.015 15.0 0.0 2.1 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 EKE42456.1 - 0.017 15.4 0.0 0.15 12.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EKE42456.1 - 0.035 14.5 0.0 0.19 12.1 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EKE42456.1 - 0.063 12.8 0.4 0.19 11.3 0.1 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF4678 PF15727.5 EKE42456.1 - 0.076 12.3 7.2 0.1 11.8 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4678) ATP_bind_1 PF03029.17 EKE42456.1 - 0.079 12.7 3.0 0.52 10.0 0.0 2.5 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein ATPase_2 PF01637.18 EKE42456.1 - 1.8 8.4 0.0 1.8 8.4 0.0 3.2 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea CENP-F_leu_zip PF10473.9 EKE42457.1 - 0.0076 16.3 3.2 0.0076 16.3 3.2 1.5 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ZapB PF06005.12 EKE42457.1 - 0.037 14.5 2.7 0.037 14.5 2.7 1.8 2 0 0 2 2 2 0 Cell division protein ZapB YqgF PF14639.6 EKE42457.1 - 0.096 12.5 1.3 0.16 11.7 1.2 1.4 1 1 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 FliJ PF02050.16 EKE42457.1 - 0.43 10.8 2.9 0.62 10.3 2.9 1.2 1 0 0 1 1 1 0 Flagellar FliJ protein Pkinase PF00069.25 EKE42458.1 - 5.5e-77 258.7 0.0 8.2e-77 258.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42458.1 - 4.4e-34 117.9 0.0 6.2e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EKE42458.1 - 0.00011 21.3 0.2 0.00015 20.8 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EKE42458.1 - 0.0019 17.6 0.1 0.0064 15.8 0.1 1.9 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EKE42458.1 - 0.0022 17.6 0.1 0.0022 17.6 0.1 2.3 3 1 0 3 3 3 1 RIO1 family Pkinase_C PF00433.24 EKE42458.1 - 0.0027 18.3 4.4 0.0059 17.3 4.4 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.6 EKE42458.1 - 0.0028 17.3 0.4 2.1 7.9 0.2 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EKE42458.1 - 0.019 14.3 0.0 0.048 13.0 0.0 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EKE42458.1 - 0.044 13.7 0.0 0.073 13.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family NHL PF01436.21 EKE42459.1 - 9.4e-12 44.3 3.2 0.0018 18.2 0.0 5.6 6 0 0 6 6 6 2 NHL repeat DUF4934 PF16288.5 EKE42459.1 - 0.0048 16.8 0.7 0.04 13.8 0.1 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4934) SGL PF08450.12 EKE42459.1 - 0.008 15.8 0.0 0.11 12.0 0.0 2.4 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 EKE42459.1 - 0.5 10.4 4.2 2.9 8.0 0.8 2.7 2 0 0 2 2 2 0 Beta-propeller repeat DSPc PF00782.20 EKE42462.1 - 8.5e-28 96.8 0.3 8.5e-28 96.8 0.3 2.2 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain LRR_4 PF12799.7 EKE42462.1 - 8.5e-09 35.6 53.0 7.1e-05 23.1 6.8 7.2 3 1 5 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE42462.1 - 4.5e-06 26.3 33.7 0.021 14.6 1.4 5.7 2 2 2 5 5 5 5 Leucine rich repeat Y_phosphatase PF00102.27 EKE42462.1 - 0.00064 19.4 0.0 0.0012 18.4 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EKE42462.1 - 0.066 13.2 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family LRR_1 PF00560.33 EKE42462.1 - 0.066 13.8 36.9 1.4 9.8 1.3 8.9 6 2 0 6 6 6 0 Leucine Rich Repeat DASH_Dam1 PF08653.10 EKE42462.1 - 0.078 12.8 1.3 0.33 10.8 0.9 2.4 1 1 0 1 1 1 0 DASH complex subunit Dam1 LRR_6 PF13516.6 EKE42462.1 - 4.9 7.5 43.5 0.18 11.9 0.4 8.6 10 1 1 11 11 11 0 Leucine Rich repeat Tox-MPTase3 PF15639.6 EKE42463.1 - 0.066 13.1 0.3 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 Metallopeptidase toxin 3 Ribosomal_L30 PF00327.20 EKE42464.1 - 0.00097 19.0 0.3 0.00097 19.0 0.3 2.3 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e PIEZO PF15917.5 EKE42464.1 - 0.3 10.5 7.8 0.42 10.1 7.8 1.1 1 0 0 1 1 1 0 Piezo 60KD_IMP PF02096.20 EKE42464.1 - 4.7 7.1 8.0 8 6.3 8.0 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein Fes1 PF08609.10 EKE42464.1 - 8.4 7.4 6.9 2.2 9.2 2.6 2.2 2 1 1 3 3 3 0 Nucleotide exchange factor Fes1 MOZ_SAS PF01853.18 EKE42465.1 - 3.2e-71 238.7 0.1 5.9e-71 237.8 0.1 1.5 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EKE42465.1 - 4.3e-24 83.9 2.9 1.1e-23 82.6 2.9 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EKE42465.1 - 3.2e-17 62.2 1.9 7.2e-17 61.0 1.9 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EKE42465.1 - 0.00021 21.7 0.0 0.00047 20.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EKE42465.1 - 0.00086 19.5 0.0 0.0025 18.0 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Agenet PF05641.12 EKE42465.1 - 0.0019 18.6 0.5 0.0087 16.5 0.1 2.3 3 0 0 3 3 3 1 Agenet domain Acetyltransf_10 PF13673.7 EKE42465.1 - 0.021 14.7 0.0 0.054 13.4 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EKE42465.1 - 0.024 14.6 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein RNHCP PF12647.7 EKE42465.1 - 0.024 14.6 0.6 0.062 13.3 0.6 1.7 1 0 0 1 1 1 0 RNHCP domain DUF1918 PF08940.11 EKE42465.1 - 0.12 12.0 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) Peptidase_S74 PF13884.6 EKE42466.1 - 2.2e-16 59.9 0.2 7.3e-16 58.2 0.1 1.9 2 0 0 2 2 2 1 Chaperone of endosialidase HELP PF03451.14 EKE42467.1 - 0.011 15.6 0.0 0.028 14.3 0.0 1.7 2 0 0 2 2 2 0 HELP motif Gag_p10 PF02337.17 EKE42467.1 - 0.1 12.6 0.3 18 5.4 0.1 2.3 2 0 0 2 2 2 0 Retroviral GAG p10 protein DUF1911 PF08929.10 EKE42467.1 - 0.13 13.1 0.4 0.24 12.2 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1911) NPL4 PF05021.15 EKE42468.1 - 3.6e-23 82.4 6.2 7.7e-14 51.8 2.7 3.4 2 1 0 2 2 2 2 NPL4 family RRM_1 PF00076.22 EKE42469.1 - 2e-07 30.7 0.3 4e-07 29.8 0.3 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EKE42469.1 - 0.0091 16.0 0.1 0.016 15.2 0.1 1.5 1 0 0 1 1 1 1 RNA binding motif Spore_YhcN_YlaJ PF09580.10 EKE42469.1 - 0.011 15.8 5.1 0.029 14.5 5.1 1.7 1 1 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) RRM_occluded PF16842.5 EKE42469.1 - 0.012 15.4 0.1 0.023 14.6 0.1 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif RWP-RK PF02042.15 EKE42470.1 - 9.4e-14 51.1 0.2 1.7e-13 50.3 0.2 1.4 1 0 0 1 1 1 1 RWP-RK domain HTH_6 PF01418.17 EKE42470.1 - 0.012 15.6 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family HTH_Tnp_ISL3 PF13542.6 EKE42470.1 - 0.07 12.6 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_AsnC-type PF13404.6 EKE42470.1 - 0.085 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Sigma70_r4_2 PF08281.12 EKE42470.1 - 0.1 12.3 0.0 0.24 11.1 0.0 1.6 1 1 0 1 1 1 0 Sigma-70, region 4 Ras PF00071.22 EKE42471.1 - 1.6e-58 196.9 0.1 1.9e-58 196.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42471.1 - 1.1e-35 122.4 0.1 1.8e-35 121.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42471.1 - 1.1e-11 44.6 0.0 1.2e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE42471.1 - 1.3e-05 24.9 0.0 3.2e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE42471.1 - 2.3e-05 24.4 0.0 3.9e-05 23.7 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE42471.1 - 3.5e-05 23.3 0.0 4.3e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE42471.1 - 0.0013 18.6 0.0 1 9.3 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EKE42471.1 - 0.0054 16.7 0.1 0.013 15.5 0.1 1.7 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 EKE42471.1 - 0.011 15.3 0.0 3.2 7.2 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B CPT PF07931.12 EKE42471.1 - 0.03 14.2 0.0 0.044 13.6 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.6 EKE42471.1 - 0.058 13.8 0.0 0.091 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain S1 PF00575.23 EKE42472.1 - 0.014 15.8 0.1 0.014 15.8 0.1 2.9 4 0 0 4 4 4 0 S1 RNA binding domain ERCC3_RAD25_C PF16203.5 EKE42473.1 - 4.3e-63 212.8 2.0 4.3e-63 212.8 2.0 1.6 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EKE42473.1 - 7e-19 68.5 1.1 1.6e-18 67.3 0.2 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_3 PF13625.6 EKE42473.1 - 8.5e-14 51.8 0.0 1.6e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EKE42473.1 - 1.3e-13 50.4 1.3 1.5e-13 50.2 0.3 1.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EKE42473.1 - 1.9e-12 47.5 0.5 1.9e-12 47.5 0.5 3.4 4 2 0 4 4 4 1 Helicase conserved C-terminal domain SWI2_SNF2 PF18766.1 EKE42473.1 - 1.6e-06 28.0 0.3 3.5e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DEAD PF00270.29 EKE42473.1 - 6.5e-05 22.8 0.2 0.00019 21.3 0.2 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1289 PF06945.13 EKE42473.1 - 0.3 10.9 1.8 1.3 8.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) Rhodanese PF00581.20 EKE42475.1 - 5.1e-08 33.4 0.0 5.9e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain RasGEF PF00617.19 EKE42476.1 - 6.6e-40 137.2 0.7 1.7e-39 135.8 0.7 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EKE42476.1 - 3.8e-12 46.4 0.1 4.1e-11 43.0 0.0 2.9 2 0 0 2 2 2 1 RasGEF N-terminal motif RhoGAP PF00620.27 EKE42476.1 - 0.0001 22.2 0.7 0.0044 16.8 0.0 2.9 3 0 0 3 3 3 1 RhoGAP domain Metallophos PF00149.28 EKE42477.1 - 1e-17 65.3 1.0 1.9e-17 64.5 1.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE42477.1 - 2.1e-08 34.5 0.8 6.3e-08 33.0 0.8 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PDZ_4 PF17816.1 EKE42477.1 - 0.019 15.4 0.1 0.061 13.7 0.1 1.9 2 0 0 2 2 2 0 PDZ domain DUF1758 PF05585.12 EKE42477.1 - 0.04 13.7 0.4 0.085 12.6 0.4 1.5 1 0 0 1 1 1 0 Putative peptidase (DUF1758) Metallophos_3 PF14582.6 EKE42477.1 - 0.053 12.8 0.2 0.19 11.0 0.1 1.8 1 1 1 2 2 2 0 Metallophosphoesterase, calcineurin superfamily Neurensin PF14927.6 EKE42478.1 - 0.034 13.9 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Neurensin Acetyltransf_1 PF00583.25 EKE42479.1 - 1.9e-12 47.4 0.1 3.1e-12 46.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EKE42479.1 - 3.9e-07 30.4 1.0 1e-06 29.1 0.6 1.8 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EKE42479.1 - 2.6e-06 27.4 0.2 5.3e-06 26.4 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EKE42479.1 - 0.0026 17.9 0.0 0.0052 16.8 0.0 1.5 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EKE42479.1 - 0.053 14.2 0.0 0.085 13.5 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain GT-D PF08759.11 EKE42479.1 - 0.12 12.0 1.2 0.18 11.5 1.2 1.2 1 0 0 1 1 1 0 Glycosyltransferase GT-D fold MCM PF00493.23 EKE42480.1 - 1.2e-93 312.4 0.0 2.6e-93 311.3 0.0 1.5 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EKE42480.1 - 1.5e-36 125.0 0.0 2.8e-36 124.1 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EKE42480.1 - 1.8e-27 95.6 2.4 3.5e-27 94.7 2.4 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain AAA_5 PF07728.14 EKE42480.1 - 2.5e-08 34.0 0.1 1.2e-07 31.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EKE42480.1 - 8.1e-08 31.9 0.3 8.8e-05 22.0 0.0 2.4 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EKE42480.1 - 0.0004 20.3 0.1 0.013 15.4 0.0 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MCM_N PF14551.6 EKE42480.1 - 0.0017 18.9 0.6 0.012 16.2 0.1 2.5 3 0 0 3 3 3 1 MCM N-terminal domain TIP49_C PF17856.1 EKE42480.1 - 0.0039 17.3 0.1 0.86 9.8 0.2 3.2 3 0 0 3 3 3 1 TIP49 AAA-lid domain Sigma54_activat PF00158.26 EKE42480.1 - 0.012 15.3 0.3 1.1 9.0 0.0 3.1 2 1 0 2 2 2 0 Sigma-54 interaction domain Zn-ribbon_8 PF09723.10 EKE42480.1 - 0.013 15.6 0.2 0.031 14.4 0.2 1.7 1 0 0 1 1 1 0 Zinc ribbon domain AAA_lid_2 PF17863.1 EKE42480.1 - 0.014 15.2 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 AAA lid domain RVT_thumb PF06817.14 EKE42480.1 - 0.16 11.8 0.1 0.47 10.3 0.1 1.7 1 0 0 1 1 1 0 Reverse transcriptase thumb domain Mg_chelatase_C PF13335.6 EKE42480.1 - 0.3 11.8 2.1 0.97 10.1 0.4 2.4 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal F-box PF00646.33 EKE42481.1 - 5.1e-07 29.4 0.4 1.5e-06 27.9 0.4 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EKE42481.1 - 8.8e-05 22.3 0.0 0.0003 20.6 0.0 1.9 1 0 0 1 1 1 1 F-box-like EF-hand_7 PF13499.6 EKE42484.1 - 6.3e-12 45.8 0.0 3.6e-08 33.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EKE42484.1 - 3e-11 42.3 0.1 0.018 15.0 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 EKE42484.1 - 4e-11 41.6 0.1 0.0008 18.8 0.4 3.4 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 EKE42484.1 - 2.3e-07 30.0 0.0 0.094 12.2 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EKE42484.1 - 3.8e-06 26.6 0.1 0.00026 20.8 0.0 2.5 2 1 1 3 3 3 1 EF-hand domain pair START PF01852.19 EKE42485.1 - 7.8e-16 58.1 0.1 8.4e-16 58.0 0.1 1.0 1 0 0 1 1 1 1 START domain RasGAP PF00616.19 EKE42489.1 - 9.8e-22 77.7 3.6 1.9e-15 57.2 1.0 2.6 2 0 0 2 2 2 2 GTPase-activator protein for Ras-like GTPase Ank_4 PF13637.6 EKE42489.1 - 1.3e-18 67.1 1.7 1e-07 32.3 0.1 4.6 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EKE42489.1 - 1.4e-13 50.7 0.3 6e-06 26.4 0.0 4.0 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EKE42489.1 - 3.3e-12 46.3 2.1 0.0072 16.7 0.2 4.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 EKE42489.1 - 8.8e-12 45.4 2.9 1.9e-05 25.2 3.2 3.1 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EKE42489.1 - 8.9e-11 41.1 3.1 0.2 12.3 0.1 5.1 4 0 0 4 4 4 3 Ankyrin repeat Bac_RepA_C PF18008.1 EKE42489.1 - 0.0098 16.2 2.0 0.022 15.1 0.1 2.5 3 0 0 3 3 3 1 Replication initiator protein A C-terminal domain Hid1 PF12722.7 EKE42491.1 - 8.1 4.4 10.6 9 4.3 10.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RNA_pol_Rpb1_3 PF04983.18 EKE42492.1 - 0.038 13.9 0.7 0.061 13.3 0.3 1.7 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 3 Pkinase PF00069.25 EKE42493.1 - 1.9e-13 50.4 4.4 3.7e-13 49.5 0.8 2.5 2 1 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42493.1 - 1.9e-11 43.8 1.1 9.6e-11 41.4 0.1 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase SurA_N_2 PF13623.6 EKE42495.1 - 0.025 14.5 0.7 0.025 14.5 0.7 2.4 2 1 0 2 2 2 0 SurA N-terminal domain SurA_N_3 PF13624.6 EKE42495.1 - 0.076 12.8 0.6 0.18 11.6 0.6 1.6 1 0 0 1 1 1 0 SurA N-terminal domain DUF4093 PF13331.6 EKE42495.1 - 0.082 13.4 0.4 0.19 12.2 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4093) Pex24p PF06398.11 EKE42495.1 - 0.14 11.1 11.3 0.011 14.8 2.7 2.3 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin RhoGAP PF00620.27 EKE42496.1 - 6.1e-37 126.8 0.0 1.4e-36 125.7 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain CNPase PF05881.12 EKE42496.1 - 0.013 15.0 0.3 0.028 14.0 0.3 1.5 1 0 0 1 1 1 0 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) DUF5600 PF18150.1 EKE42496.1 - 0.019 15.6 1.4 0.053 14.1 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5600) Npa1 PF11707.8 EKE42497.1 - 0.012 15.0 1.3 0.072 12.4 0.3 2.5 2 1 0 2 2 2 0 Ribosome 60S biogenesis N-terminal Arm PF00514.23 EKE42497.1 - 0.013 15.5 4.2 1 9.5 0.3 4.3 3 1 0 3 3 3 0 Armadillo/beta-catenin-like repeat ParcG PF10274.9 EKE42497.1 - 0.12 12.5 3.6 4.2 7.5 0.2 2.9 2 1 1 3 3 3 0 Parkin co-regulated protein ScsC_N PF18312.1 EKE42498.1 - 0.22 11.4 1.2 0.84 9.5 0.0 2.3 2 0 0 2 2 2 0 Copper resistance protein ScsC N-terminal domain MA3 PF02847.17 EKE42499.1 - 2.8e-16 59.5 2.5 4.9e-16 58.7 0.2 2.6 3 0 0 3 3 3 1 MA3 domain MIF4G PF02854.19 EKE42499.1 - 3e-07 30.3 2.1 9.1e-05 22.2 1.1 2.5 2 0 0 2 2 2 2 MIF4G domain RRM_1 PF00076.22 EKE42500.1 - 0.022 14.6 0.3 0.61 10.0 0.1 2.5 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Actin PF00022.19 EKE42501.1 - 3.4e-85 286.1 0.0 6e-84 282.0 0.0 1.9 1 1 0 1 1 1 1 Actin FtsA PF14450.6 EKE42501.1 - 0.0026 18.1 0.0 0.0096 16.3 0.0 1.9 2 0 0 2 2 2 1 Cell division protein FtsA MreB_Mbl PF06723.13 EKE42501.1 - 0.011 14.6 0.0 3.8 6.2 0.0 2.9 3 0 0 3 3 3 0 MreB/Mbl protein TLD PF07534.16 EKE42502.1 - 0.0019 18.4 0.2 0.0039 17.4 0.2 1.6 1 1 0 1 1 1 1 TLD RNA_pol_Rpb2_6 PF00562.28 EKE42503.1 - 1.7e-107 359.9 0.5 1.3e-106 357.0 0.2 2.3 2 1 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EKE42503.1 - 6.3e-29 101.0 0.1 9.7e-29 100.3 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EKE42503.1 - 2e-25 88.8 0.1 4.6e-25 87.6 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 EKE42503.1 - 1.8e-23 82.7 0.1 4.2e-23 81.5 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 EKE42503.1 - 4.5e-13 49.0 0.0 2.3e-12 46.7 0.0 2.3 2 0 0 2 2 2 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 EKE42503.1 - 7e-10 38.9 0.0 1.5e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 Zn-ribbon_8 PF09723.10 EKE42503.1 - 0.14 12.3 5.8 0.35 11.0 5.8 1.7 1 0 0 1 1 1 0 Zinc ribbon domain FYVE_2 PF02318.16 EKE42503.1 - 0.18 12.0 3.5 0.44 10.8 3.5 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger Zn_ribbon_SprT PF17283.2 EKE42503.1 - 2.6 8.0 7.9 5.7 6.9 7.9 1.6 1 0 0 1 1 1 0 SprT-like zinc ribbon domain PHD PF00628.29 EKE42505.1 - 9.8e-11 41.4 30.1 7.9e-08 32.1 15.8 2.4 2 0 0 2 2 2 2 PHD-finger zf-HC5HC2H PF13771.6 EKE42505.1 - 1.2e-07 31.9 24.0 2.2e-07 31.1 1.5 2.8 2 1 0 2 2 2 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EKE42505.1 - 2.6e-06 27.6 21.0 1.4e-05 25.2 2.1 2.3 1 1 0 2 2 2 2 PHD-zinc-finger like domain PHD_2 PF13831.6 EKE42505.1 - 0.026 14.1 9.0 0.026 14.1 9.0 3.5 3 2 0 3 3 3 0 PHD-finger C1_2 PF03107.16 EKE42505.1 - 0.027 14.8 25.0 0.19 12.0 11.3 3.3 3 0 0 3 3 3 0 C1 domain zf-PHD-like PF15446.6 EKE42505.1 - 7.5 6.1 21.2 5.9 6.5 10.1 2.8 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain Mago_nashi PF02792.14 EKE42506.1 - 1.3e-51 174.5 3.8 1.6e-51 174.2 3.8 1.0 1 0 0 1 1 1 1 Mago nashi protein Sprouty PF05210.13 EKE42507.1 - 0.025 15.0 0.6 0.075 13.4 0.0 2.0 1 1 1 2 2 2 0 Sprouty protein (Spry) FA_desaturase PF00487.24 EKE42507.1 - 0.038 13.8 0.2 0.041 13.7 0.2 1.1 1 0 0 1 1 1 0 Fatty acid desaturase HTH_23 PF13384.6 EKE42508.1 - 0.00032 20.4 0.1 0.00067 19.4 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 EKE42508.1 - 0.0038 17.2 0.2 0.22 11.5 0.0 2.5 2 0 0 2 2 2 1 Winged helix-turn helix HTH_50 PF18024.1 EKE42508.1 - 0.099 12.3 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 EKE42508.1 - 0.11 12.8 0.2 0.36 11.2 0.1 1.9 2 0 0 2 2 2 0 Transposase zf-met PF12874.7 EKE42509.1 - 0.31 11.5 18.9 0.53 10.8 5.7 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EKE42509.1 - 0.33 10.9 9.7 0.31 11.0 4.6 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-MYST PF17772.1 EKE42509.1 - 1.2 8.8 13.0 0.096 12.3 2.9 2.3 1 1 1 2 2 2 0 MYST family zinc finger domain zf-C2H2_7 PF15269.6 EKE42509.1 - 4.7 7.4 14.4 7.2 6.8 6.2 2.4 2 1 0 2 2 2 0 Zinc-finger CBFD_NFYB_HMF PF00808.23 EKE42512.1 - 1.2e-12 47.9 0.2 1.8e-12 47.3 0.2 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EKE42512.1 - 5e-08 33.4 0.4 9.2e-08 32.5 0.1 1.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EKE42512.1 - 0.011 15.8 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TFIID-18kDa PF02269.16 EKE42512.1 - 0.02 14.9 0.2 0.03 14.4 0.2 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit TAF PF02969.17 EKE42512.1 - 0.051 13.8 0.2 0.088 13.0 0.2 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) LSM PF01423.22 EKE42513.1 - 1.8e-15 56.3 1.0 2.1e-15 56.1 1.0 1.1 1 0 0 1 1 1 1 LSM domain LSM14 PF12701.7 EKE42513.1 - 0.0044 17.1 0.9 0.0055 16.8 0.9 1.1 1 0 0 1 1 1 1 Scd6-like Sm domain NAD_Gly3P_dh_N PF01210.23 EKE42513.1 - 0.05 13.6 0.0 0.059 13.4 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus BPL_C PF02237.17 EKE42513.1 - 0.073 13.0 0.0 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 Biotin protein ligase C terminal domain ComS PF17584.2 EKE42515.1 - 0.006 16.1 0.1 0.025 14.1 0.1 2.1 1 0 0 1 1 1 1 Bacillus competence protein S EMP70 PF02990.16 EKE42516.1 - 2.3e-05 23.3 20.4 0.00017 20.4 20.4 2.0 1 1 0 1 1 1 1 Endomembrane protein 70 MFS_1 PF07690.16 EKE42516.1 - 0.0012 17.8 1.4 0.0022 17.0 1.4 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily GAPT PF11770.8 EKE42516.1 - 0.47 10.3 4.3 0.55 10.1 0.2 2.6 2 1 0 2 2 2 0 GRB2-binding adapter (GAPT) TRIQK PF15168.6 EKE42517.1 - 2.7 7.9 9.9 9.5 6.2 3.3 3.0 2 1 0 2 2 2 0 Triple QxxK/R motif-containing protein family PLDc_2 PF13091.6 EKE42518.1 - 6.3e-17 61.7 1.3 8.6e-09 35.4 0.4 2.9 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EKE42518.1 - 1.1e-16 60.3 0.5 4.6e-07 29.7 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif Vps51 PF08700.11 EKE42519.1 - 1.7e-11 44.1 0.6 1.7e-11 44.1 0.6 2.9 4 0 0 4 4 2 1 Vps51/Vps67 Dor1 PF04124.12 EKE42519.1 - 9.2e-10 37.7 3.4 1.7e-09 36.8 3.4 1.4 1 0 0 1 1 1 1 Dor1-like family Sec5 PF15469.6 EKE42519.1 - 3.2e-09 36.9 3.5 3.2e-09 36.9 3.5 2.5 3 0 0 3 3 3 1 Exocyst complex component Sec5 Baculo_PEP_C PF04513.12 EKE42519.1 - 0.0027 17.7 0.7 0.0027 17.7 0.7 4.4 5 1 1 6 6 5 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4201 PF13870.6 EKE42519.1 - 0.0058 16.4 2.9 0.0058 16.4 2.9 2.9 4 0 0 4 4 3 1 Domain of unknown function (DUF4201) COG2 PF06148.11 EKE42519.1 - 0.0072 16.4 5.4 0.029 14.5 1.5 3.5 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.9 EKE42519.1 - 0.013 15.7 7.1 0.041 14.1 3.7 3.1 2 0 0 2 2 2 0 Golgi transport complex subunit 5 TACC_C PF05010.14 EKE42519.1 - 0.017 14.9 1.8 0.017 14.9 1.8 2.5 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal KxDL PF10241.9 EKE42519.1 - 0.053 13.8 2.1 0.22 11.8 0.5 2.8 2 0 0 2 2 2 0 Uncharacterized conserved protein Sec34 PF04136.15 EKE42519.1 - 0.057 13.3 4.4 0.22 11.4 2.7 2.9 2 1 0 2 2 2 0 Sec34-like family SEO_C PF14577.6 EKE42519.1 - 0.082 12.3 0.8 5.9 6.3 0.2 2.5 2 0 0 2 2 2 0 Sieve element occlusion C-terminus Spc24 PF08286.11 EKE42519.1 - 0.092 13.0 2.3 0.13 12.5 0.5 2.3 2 0 0 2 2 1 0 Spc24 subunit of Ndc80 Ku_PK_bind PF08785.11 EKE42519.1 - 0.12 12.6 2.5 5.8 7.1 0.0 3.9 5 0 0 5 5 4 0 Ku C terminal domain like CENP-H PF05837.12 EKE42519.1 - 0.2 12.1 4.0 13 6.3 2.1 2.9 2 1 0 2 2 2 0 Centromere protein H (CENP-H) DUF5446 PF17522.2 EKE42519.1 - 0.21 11.8 7.9 2 8.7 0.0 4.4 4 0 0 4 4 4 0 Family of unknown function (DUF5446) DUF5638 PF18688.1 EKE42519.1 - 0.35 11.2 7.6 0.42 11.0 3.7 3.1 2 1 0 2 2 2 0 Family of unknown function (DUF5638) OmpH PF03938.14 EKE42519.1 - 0.62 10.4 10.2 0.29 11.4 0.6 3.4 3 1 0 3 3 3 0 Outer membrane protein (OmpH-like) Laminin_II PF06009.12 EKE42519.1 - 0.75 9.8 7.8 2.3 8.2 1.3 3.8 3 1 1 4 4 4 0 Laminin Domain II NPV_P10 PF05531.12 EKE42519.1 - 0.82 10.2 5.6 2.4 8.7 0.4 3.7 4 0 0 4 4 3 0 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 EKE42519.1 - 1.2 9.7 8.6 0.25 11.9 1.7 3.2 4 0 0 4 4 3 0 Apg6 coiled-coil region Spore_GerAC PF05504.11 EKE42519.1 - 5.5 7.2 13.4 0.097 12.9 0.6 3.6 3 1 1 4 4 4 0 Spore germination B3/ GerAC like, C-terminal Mod_r PF07200.13 EKE42519.1 - 7.4 6.7 15.4 0.37 10.9 6.9 3.0 3 1 0 3 3 2 0 Modifier of rudimentary (Mod(r)) protein DUF1664 PF07889.12 EKE42519.1 - 7.8 6.6 8.9 0.79 9.8 1.0 3.2 4 0 0 4 4 2 0 Protein of unknown function (DUF1664) DUF2408 PF10303.9 EKE42519.1 - 8.5 6.9 7.6 4 8.0 2.7 2.9 2 2 0 2 2 2 0 Protein of unknown function (DUF2408) DUF724 PF05266.14 EKE42519.1 - 9.2 6.0 11.6 0.27 11.0 3.7 2.4 3 1 0 3 3 2 0 Protein of unknown function (DUF724) Ribosomal_L36e PF01158.18 EKE42520.1 - 1e-27 96.2 3.9 1.2e-27 95.9 3.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L36e DUF531 PF04407.12 EKE42520.1 - 0.065 13.3 0.2 5.2 7.1 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF531) Mistic PF11458.8 EKE42520.1 - 0.18 11.8 0.0 0.59 10.1 0.0 1.8 2 0 0 2 2 2 0 Membrane-integrating protein Mistic Spore_III_AB PF09548.10 EKE42521.1 - 0.029 14.5 0.3 0.071 13.2 0.2 1.7 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) CybS PF05328.12 EKE42522.1 - 1.3 8.7 6.9 5.1 6.8 0.1 2.5 2 1 0 2 2 2 0 CybS, succinate dehydrogenase cytochrome B small subunit SHS2_Rpb7-N PF03876.17 EKE42523.1 - 0.0032 17.8 0.0 0.0057 17.0 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RPA43_OB PF17875.1 EKE42523.1 - 0.045 14.4 0.0 0.08 13.6 0.0 1.4 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I PseudoU_synth_2 PF00849.22 EKE42524.1 - 5.7e-29 101.3 1.0 6e-29 101.2 0.1 1.5 2 0 0 2 2 2 1 RNA pseudouridylate synthase DOCK-C2 PF14429.6 EKE42526.1 - 1e-31 110.3 1.2 1.9e-31 109.4 0.5 1.8 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins PH_13 PF16652.5 EKE42526.1 - 0.019 14.7 0.3 0.064 13.1 0.1 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain Importin_rep PF18773.1 EKE42526.1 - 0.024 14.3 0.1 0.059 13.1 0.1 1.6 1 0 0 1 1 1 0 Importin 13 repeat zf-RRN7 PF11781.8 EKE42526.1 - 0.17 11.6 0.2 0.37 10.5 0.2 1.6 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Ribosomal_S5 PF00333.20 EKE42527.1 - 1.6e-26 92.1 2.2 3.3e-26 91.1 2.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EKE42527.1 - 6.2e-23 80.0 0.0 1.3e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain WD40 PF00400.32 EKE42528.1 - 3.6e-13 49.8 5.3 0.035 15.0 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 EKE42528.1 - 9.8e-08 32.1 0.1 8.5e-07 29.1 0.1 2.3 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40_3 PF15911.5 EKE42528.1 - 0.072 13.1 0.2 7.9 6.6 0.0 2.9 3 0 0 3 3 3 0 WD domain, G-beta repeat RIG-I_C PF18119.1 EKE42528.1 - 0.077 13.0 4.8 0.16 11.9 4.8 1.5 1 0 0 1 1 1 0 RIG-I receptor C-terminal domain CemA PF03040.14 EKE42528.1 - 0.09 12.7 0.8 0.16 11.9 0.8 1.4 1 0 0 1 1 1 0 CemA family Ribosomal_L15e PF00827.17 EKE42529.1 - 1.6e-80 269.3 4.6 1.9e-80 269.1 4.6 1.0 1 0 0 1 1 1 1 Ribosomal L15 ADK PF00406.22 EKE42530.1 - 3.5e-44 150.5 0.0 4.3e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EKE42530.1 - 2.4e-33 115.5 0.0 3e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EKE42530.1 - 1.1e-08 35.7 0.0 1.7e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EKE42530.1 - 4.1e-07 30.3 0.0 5.8e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EKE42530.1 - 0.00074 19.2 0.3 0.39 10.4 0.0 2.1 1 1 1 2 2 2 2 Thymidylate kinase NTPase_1 PF03266.15 EKE42530.1 - 0.0041 17.0 0.2 0.011 15.6 0.1 1.9 1 1 1 2 2 2 1 NTPase ThiS-like PF14453.6 EKE42530.1 - 0.072 13.2 0.0 0.29 11.2 0.0 2.0 1 0 0 1 1 1 0 ThiS-like ubiquitin Viral_helicase1 PF01443.18 EKE42530.1 - 0.14 11.8 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AMMECR1 PF01871.17 EKE42531.1 - 2.9e-39 134.4 0.0 3.4e-39 134.1 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 Iso_dh PF00180.20 EKE42532.1 - 9.9e-85 284.7 0.0 1.2e-84 284.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase RPN1_RPN2_N PF17781.1 EKE42534.1 - 1.9e-65 221.3 3.4 3.8e-65 220.3 3.4 1.5 1 1 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EKE42534.1 - 4.8e-24 84.1 0.0 1.4e-23 82.7 0.0 1.8 2 0 0 2 2 2 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EKE42534.1 - 1.8e-10 40.7 23.2 0.0012 19.1 0.1 7.7 8 0 0 8 8 8 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EKE42534.1 - 0.01 16.2 0.1 5.8 7.4 0.0 4.0 3 1 1 4 4 4 0 HEAT repeats FANC_SAP PF18081.1 EKE42534.1 - 0.072 13.3 0.2 20 5.4 0.0 3.1 3 0 0 3 3 3 0 Fanconi anemia-associated nuclease SAP domain Utp13 PF08625.11 EKE42534.1 - 0.074 12.9 0.7 0.24 11.3 0.7 1.9 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain Piezo_RRas_bdg PF12166.8 EKE42535.1 - 6.4e-06 25.7 0.4 7.2e-06 25.5 0.4 1.0 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain Cob_adeno_trans PF01923.18 EKE42536.1 - 0.0024 18.0 2.4 0.0024 18.0 2.4 2.1 1 1 2 3 3 3 1 Cobalamin adenosyltransferase Sod_Fe_N PF00081.22 EKE42536.1 - 4.5 7.8 8.5 0.13 12.8 1.1 2.3 2 0 0 2 2 2 0 Iron/manganese superoxide dismutases, alpha-hairpin domain Myb_DNA-binding PF00249.31 EKE42537.1 - 4.1e-11 42.9 0.0 6.5e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EKE42537.1 - 0.0022 17.8 5.5 0.0033 17.3 4.9 1.6 1 1 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EKE42537.1 - 0.018 15.3 0.7 0.083 13.2 0.1 2.4 1 1 0 2 2 2 0 Myb-like DNA-binding domain ATP-synt_E_2 PF08112.11 EKE42537.1 - 0.11 12.8 3.1 0.55 10.5 2.4 2.2 1 1 1 2 2 2 0 ATP synthase epsilon subunit LRRC37AB_C PF14914.6 EKE42537.1 - 0.74 9.7 4.8 0.24 11.3 1.0 1.8 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain TLD PF07534.16 EKE42538.1 - 7.4e-05 23.0 0.4 0.00024 21.4 0.4 1.8 1 0 0 1 1 1 1 TLD XhlA PF10779.9 EKE42538.1 - 0.013 15.7 6.5 0.013 15.7 6.5 18.8 10 5 10 20 20 20 0 Haemolysin XhlA DUF1664 PF07889.12 EKE42538.1 - 0.078 13.0 165.6 0.021 14.9 9.2 12.7 3 2 8 12 12 12 0 Protein of unknown function (DUF1664) CCB2_CCB4 PF11152.8 EKE42538.1 - 0.19 11.0 0.2 0.54 9.5 0.2 1.7 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 Rad21_Rec8_N PF04825.13 EKE42539.1 - 1.9e-37 127.8 0.2 1.6e-36 124.8 0.0 2.3 2 0 0 2 2 2 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EKE42539.1 - 2.9e-12 45.7 0.2 1.7e-11 43.2 0.0 2.2 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.14 EKE42539.1 - 0.0086 16.0 5.6 0.056 13.3 5.6 2.3 1 1 0 1 1 1 1 Segregation and condensation protein ScpA PRCC PF10253.9 EKE42539.1 - 0.17 12.6 5.6 0.37 11.6 5.6 1.5 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting His_Phos_1 PF00300.22 EKE42540.1 - 1.4e-25 90.2 0.0 2e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) IPK PF03770.16 EKE42540.1 - 4.5e-13 49.5 0.4 4.3e-08 33.3 0.2 2.6 2 0 0 2 2 2 2 Inositol polyphosphate kinase MIT PF04212.18 EKE42541.1 - 2.8e-25 88.1 14.3 1.1e-12 47.8 3.1 2.3 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain LIM PF00412.22 EKE42541.1 - 5e-06 26.7 1.5 0.00021 21.5 0.3 2.4 1 1 1 2 2 2 2 LIM domain AvrRpt-cleavage PF05627.11 EKE42541.1 - 0.0067 15.8 0.0 0.034 13.5 0.0 2.1 2 0 0 2 2 2 1 Cleavage site for pathogenic type III effector avirulence factor Avr TPR_7 PF13176.6 EKE42541.1 - 0.036 14.1 0.9 5.4 7.3 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EKE42541.1 - 0.1 12.9 0.8 9 6.7 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EKE42541.1 - 0.62 10.0 5.9 1.7 8.6 1.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EKE42541.1 - 4.6 7.6 7.7 2.2 8.6 1.3 3.2 2 1 0 3 3 3 0 Tetratricopeptide repeat CAMSAP_CH PF11971.8 EKE42542.1 - 1.3e-08 34.5 5.3 0.0016 18.2 0.0 3.4 3 0 0 3 3 3 2 CAMSAP CH domain IBR PF01485.21 EKE42543.1 - 4.7e-10 39.5 60.1 1e-07 32.1 15.1 4.3 2 1 2 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 EKE42543.1 - 8e-06 25.8 7.8 8e-06 25.8 7.8 4.4 3 1 0 3 3 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EKE42543.1 - 8.6e-06 26.0 7.5 8.6e-06 26.0 7.5 5.2 3 2 1 5 5 4 2 Ring finger domain zf-C3HC4_2 PF13923.6 EKE42543.1 - 3.3e-05 23.6 7.5 3.3e-05 23.6 7.5 5.3 3 2 2 5 5 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE42543.1 - 0.00019 21.3 7.9 0.00019 21.3 7.9 5.5 3 2 2 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EKE42543.1 - 0.0027 17.5 7.7 0.0027 17.5 7.7 4.7 3 2 2 5 5 4 1 Zinc finger, C3HC4 type (RING finger) Fe_bilin_red PF05996.12 EKE42543.1 - 0.013 15.2 1.1 0.27 10.9 0.1 2.4 2 1 0 2 2 2 0 Ferredoxin-dependent bilin reductase zf-C3HC4_4 PF15227.6 EKE42543.1 - 0.028 14.6 7.9 0.028 14.6 7.9 5.3 4 1 1 5 5 5 0 zinc finger of C3HC4-type, RING WW_1 PF18507.1 EKE42543.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 WW domain SIT PF15330.6 EKE42543.1 - 0.14 12.6 1.5 0.24 11.9 1.5 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF3837 PF12939.7 EKE42543.1 - 0.25 11.8 4.0 1.2 9.6 1.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3837) POB3_N PF17292.2 EKE42545.1 - 0.11 12.9 0.0 0.35 11.3 0.0 1.8 1 0 0 1 1 1 0 POB3-like N-terminal PH domain RNA_pol_I_A49 PF06870.12 EKE42546.1 - 9.6e-17 60.9 0.0 1.5e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor HTH_OrfB_IS605 PF12323.8 EKE42546.1 - 0.16 11.5 0.0 0.36 10.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Histone PF00125.24 EKE42547.1 - 4.9e-22 78.7 1.4 5.4e-22 78.6 1.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EKE42547.1 - 3.6e-06 27.1 0.1 5.8e-06 26.4 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EKE42547.1 - 0.00016 21.8 1.3 0.00057 20.1 0.9 1.9 1 1 1 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EKE42547.1 - 0.015 15.7 0.1 0.021 15.2 0.1 1.4 1 0 0 1 1 1 0 CENP-S protein BTV_NS2 PF04514.12 EKE42547.1 - 0.035 12.9 0.4 0.11 11.4 0.1 1.7 1 1 0 2 2 2 0 Bluetongue virus non-structural protein NS2 DUF2891 PF11199.8 EKE42547.1 - 0.11 11.4 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2891) Peptidase_C1 PF00112.23 EKE42548.1 - 1.1e-22 81.2 5.3 1.1e-22 81.2 5.3 2.8 2 1 1 3 3 3 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE42548.1 - 1.1e-07 32.2 1.8 1.1e-07 32.2 1.8 2.6 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) TAF6_C PF07571.13 EKE42549.1 - 1.4e-22 79.8 0.1 3.6e-22 78.5 0.1 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EKE42549.1 - 6.1e-13 48.7 0.4 1.7e-12 47.3 0.1 1.9 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EKE42549.1 - 9.5e-05 22.8 0.1 0.00023 21.5 0.1 1.6 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EKE42549.1 - 0.00024 21.3 0.2 0.00024 21.3 0.2 2.1 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 EKE42549.1 - 0.00026 21.0 0.1 0.0013 18.7 0.0 2.2 2 0 0 2 2 2 1 Bromodomain associated TFIID-31kDa PF02291.15 EKE42549.1 - 0.00086 19.4 0.0 0.0027 17.8 0.0 1.8 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit TFIID_20kDa PF03847.13 EKE42549.1 - 0.17 12.4 1.7 0.3 11.6 0.2 2.2 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A zf-C3HC4_3 PF13920.6 EKE42550.1 - 2.9e-15 55.8 8.2 4.7e-15 55.2 8.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EKE42550.1 - 5.3e-10 39.0 7.7 9.2e-10 38.2 7.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EKE42550.1 - 8.6e-07 29.2 10.4 1.7e-06 28.2 10.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EKE42550.1 - 4.8e-05 23.2 8.7 8e-05 22.5 8.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 EKE42550.1 - 0.0041 16.9 6.4 0.0078 16.0 6.4 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain DZR PF12773.7 EKE42550.1 - 0.24 11.5 5.4 0.54 10.3 5.4 1.6 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_2 PF13923.6 EKE42550.1 - 0.3 11.0 10.2 0.62 10.0 10.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 EKE42550.1 - 1.2 8.8 6.8 5 6.9 6.8 2.0 1 1 0 1 1 1 0 P-11 zinc finger RecR PF02132.15 EKE42550.1 - 2.8 7.6 8.9 1.9 8.2 1.1 2.8 2 1 0 2 2 2 0 RecR protein AAA_14 PF13173.6 EKE42551.1 - 0.075 13.1 1.2 0.094 12.8 1.2 1.1 1 0 0 1 1 1 0 AAA domain RIC3 PF15361.6 EKE42551.1 - 0.45 10.9 2.7 0.59 10.5 2.7 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Tetraspanin PF00335.20 EKE42552.1 - 0.32 10.7 23.0 1.9 8.1 23.3 2.0 1 1 0 1 1 1 0 Tetraspanin family DUF2207 PF09972.9 EKE42552.1 - 0.68 8.6 7.6 3.8 6.1 0.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) PH PF00169.29 EKE42554.1 - 3.6e-14 53.2 0.7 1.1e-13 51.5 0.7 1.9 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EKE42554.1 - 0.002 18.5 0.3 0.002 18.5 0.3 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain TFIIA PF03153.13 EKE42554.1 - 0.003 17.6 34.3 0.0043 17.1 34.3 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PH_8 PF15409.6 EKE42554.1 - 0.012 15.9 0.0 0.034 14.4 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain dCache_1 PF02743.18 EKE42554.1 - 2 8.2 10.1 1 9.1 6.9 2.0 2 0 0 2 2 2 0 Cache domain Macoilin PF09726.9 EKE42554.1 - 3.6 6.0 29.4 4.8 5.6 29.4 1.1 1 0 0 1 1 1 0 Macoilin family DUF3523 PF12037.8 EKE42554.1 - 6.8 6.0 38.6 15 4.8 38.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) DDR_swiveling PF18427.1 EKE42555.1 - 0.13 12.3 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 DD-reactivating factor swiveling domain SH3_1 PF00018.28 EKE42556.1 - 4.5e-18 64.6 0.1 1.1e-17 63.3 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EKE42556.1 - 1.7e-17 63.0 0.1 3.4e-17 62.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain BAR PF03114.18 EKE42556.1 - 1.3e-15 57.8 4.4 2.6e-15 56.7 4.4 1.5 1 1 0 1 1 1 1 BAR domain SH3_2 PF07653.17 EKE42556.1 - 3.4e-14 52.3 0.0 6.7e-14 51.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 EKE42556.1 - 0.00034 20.4 0.9 0.00051 19.8 0.9 1.2 1 0 0 1 1 1 1 BAR domain of APPL family Vps5 PF09325.10 EKE42556.1 - 0.077 12.5 2.6 0.18 11.3 0.5 2.0 2 0 0 2 2 2 0 Vps5 C terminal like TPR_MLP1_2 PF07926.12 EKE42556.1 - 0.21 11.6 3.9 3.7 7.6 1.2 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein YkyA PF10368.9 EKE42556.1 - 0.37 10.4 7.1 1.5 8.5 1.7 2.6 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein DegS PF05384.11 EKE42556.1 - 5.5 6.5 7.4 1.7 8.1 0.6 2.8 3 0 0 3 3 3 0 Sensor protein DegS Tfb4 PF03850.14 EKE42557.1 - 2.2e-33 115.9 2.7 2.4e-33 115.8 2.0 1.3 1 1 0 1 1 1 1 Transcription factor Tfb4 SBF PF01758.16 EKE42557.1 - 0.15 11.7 0.2 8.2 6.0 0.1 2.2 2 0 0 2 2 2 0 Sodium Bile acid symporter family zf-C3HC4_3 PF13920.6 EKE42557.1 - 1.9 8.4 12.2 1.8 8.5 8.7 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) NES_C_h PF18208.1 EKE42558.1 - 0.37 11.1 6.5 0.19 12.0 4.2 1.8 2 0 0 2 2 2 0 Nicking enzyme C-terminal middle helical domain XhlA PF10779.9 EKE42558.1 - 6.6 7.0 7.0 0.5 10.6 2.0 1.7 2 0 0 2 2 2 0 Haemolysin XhlA SPRY PF00622.28 EKE42559.1 - 6.5e-21 74.7 1.0 1.4e-19 70.4 0.4 2.3 1 1 1 2 2 2 2 SPRY domain DHHC PF01529.20 EKE42560.1 - 4.9e-32 110.9 18.8 4.9e-32 110.9 18.8 2.8 2 1 0 2 2 2 1 DHHC palmitoyltransferase Fer4_18 PF13746.6 EKE42560.1 - 0.009 16.2 5.1 0.016 15.4 5.1 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain DUF4231 PF14015.6 EKE42560.1 - 0.44 11.0 13.2 11 6.6 6.6 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Spt4 PF06093.13 EKE42560.1 - 0.53 10.4 6.4 1.3 9.2 6.4 1.7 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger LMF1 PF06762.14 EKE42560.1 - 1 8.4 9.4 0.14 11.2 0.6 2.0 1 1 1 2 2 2 0 Lipase maturation factor Metallophos PF00149.28 EKE42561.1 - 7.9e-13 49.4 0.2 4.5e-12 46.9 0.2 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE42561.1 - 1.6e-07 31.7 0.0 2.2e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain LRR_6 PF13516.6 EKE42562.1 - 0.013 15.5 27.1 4.5 7.6 0.0 10.0 11 0 0 11 11 11 0 Leucine Rich repeat VPS13_C PF16909.5 EKE42562.1 - 0.062 13.1 0.6 0.21 11.3 0.6 1.9 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal LRR_4 PF12799.7 EKE42562.1 - 1.6 9.3 0.0 1.6 9.3 0.0 11.1 5 4 7 13 13 13 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EKE42562.1 - 2 9.3 41.0 12 6.9 0.1 11.8 13 1 0 13 13 13 0 Leucine Rich Repeat Adap_comp_sub PF00928.21 EKE42563.1 - 2.7e-50 171.2 0.0 3.5e-50 170.8 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Beach PF02138.18 EKE42565.1 - 2e-06 27.4 3.2 0.0019 17.6 0.2 2.9 1 1 1 2 2 2 2 Beige/BEACH domain COPIIcoated_ERV PF07970.12 EKE42566.1 - 4.8e-64 216.2 0.2 8.4e-64 215.4 0.2 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EKE42566.1 - 2.4e-26 91.9 1.4 1.2e-25 89.7 0.1 2.2 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF4064 PF13273.6 EKE42566.1 - 0.11 12.8 0.4 15 6.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Ribosomal_L18 PF17135.4 EKE42567.1 - 1e-57 194.6 3.4 1.1e-57 194.4 3.4 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EKE42567.1 - 0.00022 21.9 0.1 0.00051 20.7 0.1 1.8 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A PDE6_gamma PF04868.12 EKE42568.1 - 0.044 14.0 0.0 0.09 13.0 0.0 1.4 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit CRAL_TRIO_2 PF13716.6 EKE42568.1 - 0.14 12.3 7.9 0.093 12.9 2.2 3.0 2 2 0 2 2 2 0 Divergent CRAL/TRIO domain ADP_ribosyl_GH PF03747.14 EKE42569.1 - 5.3e-38 131.4 0.0 6.6e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Lpp-LpqN PF10738.9 EKE42569.1 - 0.018 14.5 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Probable lipoprotein LpqN Rick_17kDa_Anti PF05433.15 EKE42569.1 - 0.11 12.4 0.9 0.23 11.4 0.9 1.4 1 0 0 1 1 1 0 Glycine zipper 2TM domain Fe-ADH PF00465.19 EKE42570.1 - 1.2e-73 248.1 0.0 1.4e-73 247.9 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EKE42570.1 - 3.1e-09 36.9 0.2 7.1e-06 25.9 0.0 2.4 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 EKE42570.1 - 0.023 13.9 0.5 1.6 7.9 0.0 2.7 2 1 0 2 2 2 0 3-dehydroquinate synthase Pkinase PF00069.25 EKE42571.1 - 5.7e-63 212.7 0.1 1.9e-62 211.0 0.0 1.9 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42571.1 - 2.8e-43 148.1 0.0 5.5e-43 147.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE42571.1 - 1.7e-05 23.8 0.0 2.6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EKE42571.1 - 0.00021 20.7 0.0 0.00059 19.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EKE42571.1 - 0.00094 19.2 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DNA_pol3_a_NII PF11490.8 EKE42571.1 - 0.58 10.0 3.3 0.25 11.3 0.1 2.1 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II PCC_BT PF18140.1 EKE42572.1 - 0.012 16.0 0.5 0.47 10.8 0.0 2.9 2 0 0 2 2 2 0 Propionyl-coenzyme A carboxylase BT domain Bac_DNA_binding PF00216.21 EKE42572.1 - 0.015 15.5 0.5 0.24 11.7 0.1 2.7 2 0 0 2 2 2 0 Bacterial DNA-binding protein He_PIG PF05345.12 EKE42572.1 - 1.1 9.5 12.0 8.1 6.7 0.1 3.9 2 1 0 2 2 2 0 Putative Ig domain Fer2_4 PF13510.6 EKE42572.1 - 3.4 7.8 6.0 26 5.0 0.3 3.9 4 1 0 4 4 4 0 2Fe-2S iron-sulfur cluster binding domain Glyco_hydro_31 PF01055.26 EKE42573.1 - 4.1e-140 467.8 8.3 5.5e-140 467.4 8.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EKE42573.1 - 2.8e-18 66.0 0.2 8.8e-18 64.4 0.2 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 EKE42573.1 - 0.07 13.4 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) DUF2070 PF09843.9 EKE42575.1 - 0.75 8.0 17.0 0.84 7.8 17.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Ras PF00071.22 EKE42576.1 - 4.4e-55 185.7 1.5 4.4e-55 185.7 1.5 1.4 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EKE42576.1 - 1.6e-33 115.5 0.3 3.1e-33 114.6 0.3 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42576.1 - 4.8e-18 65.2 0.8 6.3e-18 64.8 0.3 1.4 1 1 1 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE42576.1 - 2.5e-09 36.9 0.3 3.5e-09 36.4 0.3 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EKE42576.1 - 1.7e-06 28.1 1.7 0.01 15.7 0.1 2.2 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EKE42576.1 - 4.8e-06 26.6 0.0 1.1e-05 25.5 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE42576.1 - 1.3e-05 24.8 0.4 3.2e-05 23.5 0.3 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EKE42576.1 - 0.00031 20.3 0.5 0.0024 17.4 0.5 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.18 EKE42576.1 - 0.0065 15.8 0.2 0.0065 15.8 0.2 2.0 1 1 1 2 2 2 1 Septin SRPRB PF09439.10 EKE42576.1 - 0.0082 15.6 0.0 0.017 14.6 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EKE42576.1 - 0.017 14.7 0.1 0.028 13.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region mCpol PF18182.1 EKE42576.1 - 0.029 14.7 0.6 1.7 9.0 0.0 2.4 2 0 0 2 2 2 0 minimal CRISPR polymerase domain G-alpha PF00503.20 EKE42576.1 - 0.064 12.4 2.8 1.2 8.2 2.8 2.4 1 1 0 1 1 1 0 G-protein alpha subunit TniB PF05621.11 EKE42576.1 - 0.095 12.1 0.1 0.54 9.6 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein NifT PF06988.11 EKE42576.1 - 2.3 8.1 6.9 1.9 8.3 0.2 2.5 2 0 0 2 2 2 0 NifT/FixU protein Ribosomal_L18_c PF14204.6 EKE42576.1 - 7.7 7.5 15.0 0.19 12.7 1.2 2.5 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region Pkinase PF00069.25 EKE42577.1 - 1.9e-65 220.9 0.1 2.5e-65 220.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42577.1 - 1.4e-49 168.8 0.0 2e-49 168.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EKE42577.1 - 7.8e-05 21.8 6.1 0.073 12.0 1.2 2.5 3 0 0 3 3 3 2 Haspin like kinase domain Kinase-like PF14531.6 EKE42577.1 - 0.00023 20.6 0.0 0.0025 17.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EKE42577.1 - 0.0048 15.7 2.9 0.0098 14.7 0.1 2.1 2 0 0 2 2 2 1 Fungal protein kinase Seadorna_VP7 PF07387.11 EKE42577.1 - 0.0048 16.0 0.6 0.0093 15.1 0.6 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 EKE42577.1 - 0.2 11.5 0.1 0.76 9.6 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family CH PF00307.31 EKE42578.1 - 6.9e-20 71.3 5.4 1.4e-14 54.2 0.5 2.7 2 1 1 3 3 3 2 Calponin homology (CH) domain Phage_GP20 PF06810.11 EKE42579.1 - 0.056 13.2 0.4 0.056 13.2 0.4 3.8 3 1 1 4 4 4 0 Phage minor structural protein GP20 OST-HTH PF12872.7 EKE42579.1 - 0.075 12.9 1.6 13 5.7 0.0 3.0 2 1 1 3 3 3 0 OST-HTH/LOTUS domain CENP-F_leu_zip PF10473.9 EKE42579.1 - 0.13 12.2 38.3 0.46 10.5 18.8 3.2 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Vac_Fusion PF02346.16 EKE42579.1 - 0.46 10.2 15.6 0.36 10.5 1.6 3.5 3 1 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Octopine_DH PF02317.17 EKE42579.1 - 0.81 9.8 6.7 5.1 7.2 1.0 2.5 2 0 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain PI3K_P85_iSH2 PF16454.5 EKE42579.1 - 0.89 9.1 29.8 6.7 6.3 24.1 2.9 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Rab5-bind PF09311.11 EKE42579.1 - 0.91 8.8 33.2 0.79 9.1 0.7 3.2 2 1 1 3 3 3 0 Rabaptin-like protein Cep57_CLD_2 PF14197.6 EKE42579.1 - 2.5 8.3 14.4 2.8 8.1 6.5 4.1 3 1 0 3 3 3 0 Centrosome localisation domain of PPC89 TMPIT PF07851.13 EKE42579.1 - 3.8 6.7 25.2 2.3 7.4 3.1 3.2 3 0 0 3 3 3 0 TMPIT-like protein Jnk-SapK_ap_N PF09744.9 EKE42579.1 - 4.7 7.4 36.0 0.45 10.7 10.9 3.4 2 2 0 3 3 3 0 JNK_SAPK-associated protein-1 BLOC1_2 PF10046.9 EKE42579.1 - 5.3 7.4 27.9 7.6 6.9 9.2 3.7 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG17 PF04108.12 EKE42579.1 - 7.1 5.6 30.6 1.3 8.1 4.1 3.5 3 1 0 3 3 3 0 Autophagy protein Apg17 DUF2935 PF11155.8 EKE42579.1 - 7.7 6.9 18.1 9.5 6.6 7.8 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF2935) ALS_ss_C PF10369.9 EKE42581.1 - 0.029 14.6 1.9 0.064 13.5 0.2 2.5 3 0 0 3 3 3 0 Small subunit of acetolactate synthase VWA PF00092.28 EKE42582.1 - 2.4e-11 44.2 0.0 3.9e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EKE42582.1 - 2.7e-07 31.2 0.0 6.4e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain LpoB PF13036.6 EKE42582.1 - 0.0085 16.0 0.5 0.025 14.5 0.1 1.9 2 0 0 2 2 2 1 Peptidoglycan-synthase activator LpoB Integrin_beta PF00362.18 EKE42582.1 - 0.087 12.5 0.1 0.47 10.1 0.1 2.0 1 1 0 1 1 1 0 Integrin beta chain VWA domain Molybdopterin PF00384.22 EKE42582.1 - 0.11 11.4 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin oxidoreductase Alg14 PF08660.11 EKE42584.1 - 3.3e-55 186.7 0.4 6e-55 185.9 0.4 1.4 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Glyco_tran_28_C PF04101.16 EKE42584.1 - 4.4e-25 88.6 0.2 7.2e-25 87.9 0.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.6 EKE42584.1 - 0.0098 15.2 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 1 Tmemb_9 PF05434.11 EKE42585.1 - 0.0049 16.8 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 TMEM9 DUF3139 PF11337.8 EKE42585.1 - 0.077 13.6 3.7 0.84 10.3 1.1 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) EphA2_TM PF14575.6 EKE42585.1 - 0.11 13.4 0.0 0.28 12.1 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 EKE42585.1 - 0.17 12.8 6.4 1.1 10.3 6.4 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Orf78 PF06024.12 EKE42585.1 - 0.31 11.4 1.8 1.2 9.4 1.8 2.0 1 0 0 1 1 1 0 Orf78 (ac78) Collectrin PF16959.5 EKE42585.1 - 7.4 6.3 9.9 24 4.7 9.9 1.9 1 0 0 1 1 1 0 Renal amino acid transporter PhoLip_ATPase_C PF16212.5 EKE42586.1 - 2.6e-46 158.4 33.3 2.6e-46 158.4 33.3 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 EKE42586.1 - 3.2e-14 52.8 0.1 1e-12 48.0 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) PhoLip_ATPase_N PF16209.5 EKE42586.1 - 4.6e-14 51.9 8.0 4.6e-14 51.9 8.0 3.0 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EKE42586.1 - 4.9e-11 42.5 0.0 4.9e-11 42.5 0.0 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EKE42586.1 - 6.8e-11 42.9 0.3 3.3e-06 27.5 0.1 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EKE42586.1 - 0.0067 16.2 2.5 0.03 14.1 0.1 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4392 PF14336.6 EKE42586.1 - 0.029 13.8 0.1 0.065 12.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4392) CdvA PF18822.1 EKE42586.1 - 0.36 10.6 2.7 0.39 10.5 0.2 2.2 2 0 0 2 2 2 0 CdvA-like coiled-coil domain NifU_N PF01592.16 EKE42588.1 - 7.2e-43 145.8 0.6 2.2e-42 144.2 0.1 2.0 2 0 0 2 2 2 1 NifU-like N terminal domain NifU PF01106.17 EKE42588.1 - 1.6e-14 53.8 0.5 4.5e-14 52.3 0.5 1.8 1 0 0 1 1 1 1 NifU-like domain Fer2_BFD PF04324.15 EKE42588.1 - 9.6e-12 45.1 2.5 1.7e-10 41.1 0.8 3.4 3 0 0 3 3 3 1 BFD-like [2Fe-2S] binding domain RhoGEF PF00621.20 EKE42589.1 - 1.4e-47 162.2 3.3 3.9e-47 160.8 3.3 1.8 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 EKE42589.1 - 0.013 15.4 2.9 0.046 13.5 2.9 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain PH PF00169.29 EKE42589.1 - 0.043 14.3 0.6 0.096 13.2 0.6 1.6 1 0 0 1 1 1 0 PH domain Pkinase_Tyr PF07714.17 EKE42590.1 - 4.6e-53 180.1 0.0 7.2e-53 179.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE42590.1 - 1.6e-52 178.5 0.0 2.7e-52 177.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE42590.1 - 4.4e-08 32.3 0.0 7.2e-08 31.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase VSP PF03302.13 EKE42590.1 - 0.0074 15.2 41.7 0.052 12.4 32.4 2.2 1 1 1 2 2 2 2 Giardia variant-specific surface protein Kdo PF06293.14 EKE42590.1 - 0.0077 15.6 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EKE42590.1 - 0.019 14.3 0.0 0.031 13.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like SP_C-Propep PF08999.10 EKE42590.1 - 0.15 11.9 0.5 0.39 10.5 0.5 1.6 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Furin-like_2 PF15913.5 EKE42590.1 - 0.83 9.8 37.1 0.084 13.0 12.9 3.2 1 1 2 3 3 3 0 Furin-like repeat, cysteine-rich GAGA_bind PF06217.12 EKE42592.1 - 0.056 13.7 5.9 0.066 13.5 5.9 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family RNA_pol_Rpb1_5 PF04998.17 EKE42593.1 - 1.5e-62 211.5 0.4 3e-62 210.5 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_3 PF04983.18 EKE42593.1 - 7e-32 110.5 0.4 7e-32 110.5 0.4 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EKE42593.1 - 7.7e-21 74.1 3.5 8.6e-21 73.9 0.0 2.9 4 0 0 4 4 4 1 RNA polymerase Rpb1, domain 4 Ral PF11058.8 EKE42593.1 - 0.063 12.8 1.3 1.2 8.7 0.1 3.1 3 0 0 3 3 3 0 Antirestriction protein Ral LemA PF04011.12 EKE42594.1 - 0.0031 17.4 3.3 0.17 11.7 0.2 2.2 1 1 1 2 2 2 1 LemA family DUF2968 PF11180.8 EKE42594.1 - 0.0089 15.7 3.2 0.0089 15.7 3.2 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2968) AAA_11 PF13086.6 EKE42594.1 - 0.025 14.4 8.8 0.029 14.2 8.8 1.0 1 0 0 1 1 1 0 AAA domain BLOC1_2 PF10046.9 EKE42594.1 - 0.027 14.7 3.3 0.027 14.7 3.3 2.9 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MbeD_MobD PF04899.12 EKE42594.1 - 0.03 14.4 0.3 0.096 12.8 0.1 2.0 2 0 0 2 2 2 0 MbeD/MobD like DUF3584 PF12128.8 EKE42594.1 - 0.034 11.7 10.6 0.039 11.5 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) LPP PF04728.13 EKE42594.1 - 0.04 14.3 8.5 4.4 7.8 5.2 3.5 2 1 0 2 2 2 0 Lipoprotein leucine-zipper Sulfatase_C PF14707.6 EKE42594.1 - 0.12 13.1 1.4 0.25 12.1 1.4 1.8 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF4407 PF14362.6 EKE42594.1 - 0.17 11.2 5.9 0.22 10.9 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V-SNARE PF05008.15 EKE42594.1 - 0.2 12.1 12.5 0.22 11.9 7.5 2.9 2 2 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Spc7 PF08317.11 EKE42594.1 - 0.25 10.2 18.8 1.7 7.5 18.8 2.4 1 1 0 1 1 1 0 Spc7 kinetochore protein YtxH PF12732.7 EKE42594.1 - 0.43 11.2 2.2 2.2 8.9 2.2 2.1 1 1 0 1 1 1 0 YtxH-like protein SlyX PF04102.12 EKE42594.1 - 0.56 10.9 7.2 0.36 11.5 4.4 2.2 2 1 0 2 2 2 0 SlyX DUF4140 PF13600.6 EKE42594.1 - 0.69 10.4 5.7 0.36 11.3 1.6 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) FapA PF03961.13 EKE42594.1 - 1 7.9 18.1 4.1 5.9 18.1 1.8 1 1 0 1 1 1 0 Flagellar Assembly Protein A DASH_Spc34 PF08657.10 EKE42594.1 - 1.3 8.8 12.6 0.74 9.6 10.8 1.5 1 1 0 1 1 1 0 DASH complex subunit Spc34 Exonuc_VII_L PF02601.15 EKE42594.1 - 1.3 8.5 9.1 1.6 8.3 9.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit HMMR_N PF15905.5 EKE42594.1 - 2 7.8 20.0 3 7.2 20.0 1.3 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF2203 PF09969.9 EKE42594.1 - 2 9.1 7.5 0.95 10.2 3.4 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Prefoldin PF02996.17 EKE42594.1 - 3.8 7.5 20.0 0.083 12.8 2.0 3.2 2 1 0 3 3 3 0 Prefoldin subunit Prefoldin_2 PF01920.20 EKE42594.1 - 3.8 7.5 24.5 0.28 11.2 4.7 3.1 1 1 2 3 3 3 0 Prefoldin subunit DUF1664 PF07889.12 EKE42594.1 - 3.8 7.6 11.4 4.9 7.2 5.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ABC_tran_CTD PF16326.5 EKE42594.1 - 4.7 7.5 15.7 1.2 9.4 9.1 2.5 2 2 0 2 2 2 0 ABC transporter C-terminal domain FlaC_arch PF05377.11 EKE42594.1 - 4.7 7.7 16.3 0.3 11.5 2.2 3.4 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) ING PF12998.7 EKE42594.1 - 5.4 7.7 14.7 1.6 9.4 8.0 2.1 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Atg14 PF10186.9 EKE42594.1 - 5.7 5.9 13.0 9.9 5.1 13.0 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NPV_P10 PF05531.12 EKE42594.1 - 6.4 7.3 8.7 0.56 10.7 2.2 2.3 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein BST2 PF16716.5 EKE42594.1 - 9.1 6.9 17.2 1.3 9.7 7.6 2.7 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DASH_Dam1 PF08653.10 EKE42594.1 - 9.4 6.1 8.6 3.8 7.4 0.5 3.1 2 1 1 3 3 3 0 DASH complex subunit Dam1 XhlA PF10779.9 EKE42594.1 - 9.5 6.5 15.9 0.064 13.5 3.1 2.8 3 1 0 3 3 3 0 Haemolysin XhlA DivIC PF04977.15 EKE42594.1 - 9.6 6.1 19.0 0.29 10.9 5.7 3.2 2 1 1 3 3 3 0 Septum formation initiator Actin PF00022.19 EKE42595.1 - 2.2e-52 178.0 0.0 6.2e-51 173.3 0.0 2.0 1 1 0 1 1 1 1 Actin HMG_box PF00505.19 EKE42596.1 - 6.7e-09 36.0 0.6 6.7e-09 36.0 0.6 3.4 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EKE42596.1 - 2.3e-06 28.1 0.9 2.3e-06 28.1 0.9 3.5 3 0 0 3 3 3 1 HMG-box domain SR-25 PF10500.9 EKE42596.1 - 0.0055 16.4 33.0 0.0055 16.4 33.0 2.7 1 1 2 3 3 3 1 Nuclear RNA-splicing-associated protein Chorion_2 PF03964.15 EKE42596.1 - 1.1 10.1 9.6 2 9.3 9.6 1.4 1 0 0 1 1 1 0 Chorion family 2 DUF4614 PF15391.6 EKE42596.1 - 2.5 8.1 16.2 0.79 9.7 11.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) POX PF07526.11 EKE42596.1 - 2.8 8.5 9.8 0.5 10.9 5.3 1.9 2 0 0 2 2 2 0 Associated with HOX Neur_chan_memb PF02932.16 EKE42596.1 - 2.9 7.9 14.9 1.5 8.8 8.5 2.1 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF3464 PF11947.8 EKE42596.1 - 4.5 7.0 8.6 1.2 8.8 3.1 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 CDKN3 PF05706.12 EKE42597.1 - 4e-08 33.1 0.1 7e-08 32.3 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.20 EKE42597.1 - 6.2e-06 26.1 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EKE42597.1 - 1.3e-05 25.4 0.0 2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EKE42597.1 - 2.3e-05 24.5 0.0 3.1e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EKE42597.1 - 3.7e-05 23.4 0.0 5.2e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 EKE42597.1 - 0.00029 20.5 0.0 0.00059 19.4 0.0 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family Myotub-related PF06602.14 EKE42597.1 - 0.035 13.1 0.0 0.046 12.6 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain AA_kinase PF00696.28 EKE42597.1 - 0.035 13.7 0.0 0.05 13.2 0.0 1.2 1 0 0 1 1 1 0 Amino acid kinase family Ski_Sno PF02437.17 EKE42597.1 - 0.066 13.0 0.9 0.87 9.4 0.0 3.0 3 0 0 3 3 3 0 SKI/SNO/DAC family DUF2009 PF09418.10 EKE42598.1 - 5.5e-133 444.4 0.4 7.1e-133 444.0 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) Crust_neurohorm PF01147.17 EKE42598.1 - 0.15 11.9 0.2 0.34 10.8 0.2 1.5 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family RhoGAP PF00620.27 EKE42599.1 - 4.2e-19 68.9 0.0 4.2e-19 68.9 0.0 2.5 3 1 1 4 4 4 1 RhoGAP domain DivIC PF04977.15 EKE42599.1 - 0.081 12.7 0.9 0.42 10.4 0.0 2.4 2 0 0 2 2 2 0 Septum formation initiator Cytokin_check_N PF10407.9 EKE42599.1 - 0.13 12.3 2.0 9.3 6.3 0.3 3.1 3 0 0 3 3 3 0 Cdc14 phosphatase binding protein N-terminus WH2 PF02205.20 EKE42600.1 - 5.9e-14 51.4 5.4 2e-07 30.6 0.5 3.2 3 0 0 3 3 3 3 WH2 motif RRM_1 PF00076.22 EKE42602.1 - 5.6e-09 35.7 0.2 1.1e-08 34.8 0.1 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1499 PF07386.11 EKE42604.1 - 4.4 7.9 6.6 1.7 9.2 2.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1499) YpjP PF14005.6 EKE42604.1 - 6.3 6.9 8.8 1.3 9.1 4.1 2.2 2 2 0 2 2 2 0 YpjP-like protein MIEAP PF16026.5 EKE42604.1 - 10 6.3 12.9 8.4 6.6 9.7 2.2 1 1 1 2 2 2 0 Mitochondria-eating protein HEAT_2 PF13646.6 EKE42605.1 - 0.00014 22.2 0.0 0.0042 17.4 0.0 3.4 5 0 0 5 5 5 1 HEAT repeats HEAT_EZ PF13513.6 EKE42605.1 - 0.00014 22.2 0.2 0.085 13.4 0.0 4.0 4 1 1 5 5 5 1 HEAT-like repeat HEAT PF02985.22 EKE42605.1 - 0.00041 20.4 0.4 0.47 10.8 0.0 5.4 6 0 0 6 6 6 1 HEAT repeat HTH_Tnp_1_2 PF13022.6 EKE42605.1 - 0.029 14.5 0.2 0.082 13.1 0.2 1.7 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase BPD_transp_2 PF02653.16 EKE42606.1 - 0.014 14.6 2.9 0.017 14.3 2.9 1.0 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component DHHC PF01529.20 EKE42606.1 - 0.05 13.7 3.0 0.057 13.5 3.0 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase SPT_ssu-like PF11779.8 EKE42606.1 - 0.66 9.6 6.9 3.5 7.3 0.0 2.2 2 0 0 2 2 2 0 Small subunit of serine palmitoyltransferase-like UPF0542 PF15086.6 EKE42607.1 - 7.3 6.6 12.9 80 3.3 1.8 4.4 3 1 0 3 3 3 0 Uncharacterised protein family UPF0542 DUF2838 PF10998.8 EKE42609.1 - 3.4e-34 117.4 10.9 3.4e-34 117.4 10.9 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF2838) Ank_5 PF13857.6 EKE42610.1 - 3.7e-14 52.6 0.9 2e-06 28.0 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EKE42610.1 - 3.4e-13 50.0 3.6 3.1e-06 27.7 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE42610.1 - 4e-13 49.6 2.6 0.00022 21.7 0.1 4.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Patatin PF01734.22 EKE42610.1 - 2.3e-10 41.0 0.0 4.6e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase Ank_3 PF13606.6 EKE42610.1 - 2.3e-08 33.6 1.4 0.25 12.0 0.1 5.1 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 EKE42610.1 - 8.3e-06 26.0 0.1 0.87 10.2 0.2 4.3 4 0 0 4 4 4 2 Ankyrin repeat UCH PF00443.29 EKE42611.1 - 7.3e-42 143.6 7.5 7.3e-42 143.6 7.5 3.1 4 1 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE42611.1 - 1.3e-12 48.0 7.7 1.3e-12 48.0 7.7 3.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MA3 PF02847.17 EKE42611.1 - 1.4 9.0 5.5 1.2 9.1 0.1 3.8 4 0 0 4 4 4 0 MA3 domain Nitroreductase PF00881.24 EKE42612.1 - 9.7e-24 84.3 0.1 1.6e-11 44.5 0.0 2.1 1 1 0 2 2 2 2 Nitroreductase family TM1586_NiRdase PF14512.6 EKE42612.1 - 4.3e-09 36.3 0.3 0.00068 19.3 0.0 3.0 1 1 2 3 3 3 3 Putative TM nitroreductase NadA PF02445.16 EKE42612.1 - 0.065 12.4 0.0 0.084 12.0 0.0 1.1 1 0 0 1 1 1 0 Quinolinate synthetase A protein TLD PF07534.16 EKE42613.1 - 1.2e-05 25.6 0.8 3e-05 24.2 0.7 1.7 1 1 1 2 2 2 2 TLD Hexapep PF00132.24 EKE42614.1 - 4.5e-13 48.3 13.3 1.9e-09 36.9 3.4 2.5 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EKE42614.1 - 0.00046 19.9 3.1 0.00046 19.9 3.1 3.0 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase SATase_N PF06426.14 EKE42614.1 - 0.0038 17.6 0.0 0.0075 16.6 0.0 1.5 1 0 0 1 1 1 1 Serine acetyltransferase, N-terminal eIF3_p135 PF12807.7 EKE42614.1 - 0.31 11.1 2.7 19 5.2 0.2 2.6 2 1 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 DAGK_acc PF00609.19 EKE42615.1 - 6.8e-39 133.8 0.0 1e-38 133.2 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EKE42615.1 - 1.8e-18 66.4 0.0 3.4e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 EKE42615.1 - 1.1e-12 47.6 47.5 1.7e-05 24.6 7.3 3.6 3 1 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EKE42615.1 - 0.0015 18.8 37.6 0.0052 17.1 4.8 3.4 3 0 0 3 3 3 3 C1 domain MFS_1 PF07690.16 EKE42616.1 - 1.4e-17 63.7 36.1 1.4e-17 63.7 36.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EKE42616.1 - 1.4e-08 33.7 25.2 2.2e-08 33.1 25.2 1.4 1 0 0 1 1 1 1 MFS/sugar transport protein YpmT PF17431.2 EKE42616.1 - 0.47 10.5 7.6 1.2 9.2 0.3 3.8 3 0 0 3 3 3 0 Uncharacterized YmpT-like Ras PF00071.22 EKE42617.1 - 7.5e-22 77.7 0.5 8.9e-22 77.4 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42617.1 - 6.2e-14 52.2 0.1 1.1e-13 51.4 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EKE42617.1 - 0.00059 19.8 2.9 0.24 11.3 0.3 2.8 2 1 1 3 3 3 2 RsgA GTPase Arf PF00025.21 EKE42617.1 - 0.00095 18.7 0.3 0.0012 18.4 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 EKE42617.1 - 0.02 14.4 0.0 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 EKE42617.1 - 0.032 14.0 0.1 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TatD_DNase PF01026.21 EKE42618.1 - 8e-29 100.8 0.2 3.6e-28 98.6 0.0 1.8 1 1 1 2 2 2 1 TatD related DNase eIF-5_eIF-2B PF01873.17 EKE42619.1 - 4.7e-34 116.7 1.1 8.3e-34 116.0 1.1 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 SAM_KSR1 PF13543.6 EKE42619.1 - 0.072 13.2 1.4 1.8 8.7 0.0 2.8 2 1 1 3 3 3 0 SAM like domain present in kinase suppressor RAS 1 zf-ACC PF17848.1 EKE42619.1 - 0.082 13.0 2.7 6.5 6.9 0.1 2.7 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain RhoGAP PF00620.27 EKE42620.1 - 0.00019 21.3 0.1 0.00046 20.0 0.1 1.6 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 EKE42620.1 - 0.00019 21.0 0.0 0.00031 20.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DpnI_C PF17726.1 EKE42620.1 - 0.057 13.6 0.5 0.33 11.1 0.1 2.5 3 0 0 3 3 3 0 Dam-replacing HTH domain RIX1 PF08167.12 EKE42620.1 - 0.063 13.0 0.3 0.23 11.2 0.2 2.0 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis DAGK_acc PF00609.19 EKE42621.1 - 5.2e-10 39.9 0.0 1.2e-09 38.7 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain C1_1 PF00130.22 EKE42621.1 - 3.4e-08 33.3 50.6 0.00054 19.8 7.9 3.4 3 0 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EKE42621.1 - 0.0029 17.9 3.7 0.0029 17.9 3.7 4.0 4 0 0 4 4 4 2 C1 domain RhoGEF PF00621.20 EKE42622.1 - 3.1e-43 148.1 2.7 2.9e-42 145.0 2.0 2.5 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 EKE42622.1 - 1.6e-13 50.6 17.8 4.3e-13 49.2 17.8 1.8 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 EKE42622.1 - 1.3e-07 32.0 0.8 1.2e-06 28.9 0.0 2.7 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 EKE42622.1 - 0.0053 16.6 0.4 0.1 12.4 0.2 3.0 1 1 1 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 EKE42622.1 - 0.0092 16.4 3.2 1.9 9.0 0.0 3.4 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EKE42622.1 - 0.017 15.4 0.0 0.046 14.0 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain C2 PF00168.30 EKE42623.1 - 6.5e-21 74.6 0.1 1.1e-20 73.8 0.1 1.4 1 0 0 1 1 1 1 C2 domain RRM_1 PF00076.22 EKE42624.1 - 8.6e-28 96.0 3.0 3.7e-15 55.5 0.2 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 EKE42624.1 - 1.4e-24 85.0 30.4 2.5e-06 27.3 2.6 4.5 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_4 PF14392.6 EKE42624.1 - 3e-08 33.2 24.2 0.026 14.3 0.1 4.8 5 0 0 5 5 5 4 Zinc knuckle RNA_bind PF08675.11 EKE42624.1 - 3.6e-05 23.7 0.0 0.0001 22.3 0.0 1.7 1 0 0 1 1 1 1 RNA binding domain zf-CCHC_2 PF13696.6 EKE42624.1 - 0.0013 18.5 34.4 0.14 12.0 2.2 4.4 4 0 0 4 4 4 3 Zinc knuckle ANAPC8 PF04049.13 EKE42624.1 - 0.01 15.9 1.2 0.01 15.9 1.2 2.4 4 0 0 4 4 4 1 Anaphase promoting complex subunit 8 / Cdc23 Limkain-b1 PF11608.8 EKE42624.1 - 0.011 15.8 0.9 0.37 10.9 0.1 2.6 2 0 0 2 2 2 0 Limkain b1 RRM_5 PF13893.6 EKE42624.1 - 0.013 15.1 0.7 2.9 7.5 0.1 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE42624.1 - 0.014 15.4 1.8 0.037 14.0 0.0 2.7 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif zf-CCHC_6 PF15288.6 EKE42624.1 - 0.016 15.0 28.1 0.11 12.4 3.2 5.2 2 1 3 5 5 5 0 Zinc knuckle zf-CCHC_3 PF13917.6 EKE42624.1 - 0.71 9.9 18.3 3 7.9 0.3 4.4 1 1 3 4 4 4 0 Zinc knuckle AFP PF02420.15 EKE42624.1 - 1.6 9.3 4.3 1.9e+02 2.9 0.1 4.6 4 0 0 4 4 4 0 Insect antifreeze protein repeat PHD_4 PF16866.5 EKE42624.1 - 3.9 7.7 29.8 0.45 10.6 4.8 4.4 3 1 2 5 5 4 0 PHD-finger Toxin_13 PF07822.11 EKE42625.1 - 5.3 7.3 7.6 4.6 7.4 4.9 2.1 2 0 0 2 2 2 0 Neurotoxin B-IV-like protein Skp1_POZ PF03931.15 EKE42627.1 - 5.2e-14 52.2 0.0 7.7e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain BTB PF00651.31 EKE42627.1 - 0.0022 18.2 0.0 0.0034 17.6 0.0 1.4 1 1 0 1 1 1 1 BTB/POZ domain zf-RING_2 PF13639.6 EKE42628.1 - 0.00012 22.3 9.1 0.00012 22.3 9.1 3.0 2 1 1 3 3 3 1 Ring finger domain zf-RING_11 PF17123.5 EKE42628.1 - 0.00021 21.0 4.4 0.00021 21.0 4.4 4.1 5 0 0 5 5 5 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EKE42628.1 - 0.00053 19.9 5.9 0.00053 19.9 5.9 3.5 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EKE42628.1 - 0.0007 19.4 9.2 0.0007 19.4 9.2 2.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE42628.1 - 0.0063 16.3 9.3 0.0063 16.3 9.3 3.5 2 2 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 EKE42628.1 - 0.019 15.1 15.5 0.019 15.1 15.5 2.9 3 1 0 3 3 3 0 B-box zinc finger MS_channel PF00924.18 EKE42629.1 - 2.7e-11 43.4 6.0 2.7e-11 43.4 6.0 1.9 2 0 0 2 2 2 1 Mechanosensitive ion channel HTH_9 PF08221.11 EKE42630.1 - 1.6e-08 34.5 2.2 0.0053 16.8 0.1 3.6 3 0 0 3 3 3 3 RNA polymerase III subunit RPC82 helix-turn-helix domain RNA_pol_Rpc82 PF05645.13 EKE42630.1 - 0.00015 21.6 1.3 0.015 15.1 0.4 3.3 4 0 0 4 4 4 1 RNA polymerase III subunit RPC82 TFIIE_alpha PF02002.17 EKE42630.1 - 0.029 14.2 0.1 0.52 10.2 0.0 2.7 2 0 0 2 2 2 0 TFIIE alpha subunit TLD PF07534.16 EKE42631.1 - 0.0034 17.6 1.7 0.0064 16.7 1.7 1.5 1 0 0 1 1 1 1 TLD eRF1_2 PF03464.15 EKE42632.1 - 1.1e-41 142.3 0.0 2e-41 141.4 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EKE42632.1 - 2.3e-35 121.5 1.3 6.9e-35 120.0 0.1 2.2 2 1 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.15 EKE42632.1 - 1.1e-16 61.0 0.0 2.3e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 EKE42632.1 - 9e-06 26.0 0.0 1.4e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 EKE42632.1 - 7.3e-05 23.0 0.0 0.00016 21.9 0.0 1.5 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 VanY PF02557.17 EKE42632.1 - 0.039 13.7 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase Ribosomal_L7Ae PF01248.26 EKE42632.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Rpn9_C PF18261.1 EKE42632.1 - 0.33 10.6 2.1 0.75 9.4 2.1 1.5 1 0 0 1 1 1 0 Rpn9 C-terminal helix Zip PF02535.22 EKE42633.1 - 1.8e-35 122.8 19.0 9.5e-34 117.1 19.0 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter PqiA PF04403.13 EKE42633.1 - 1.2 9.0 7.6 3.2 7.6 7.6 1.8 1 1 0 1 1 1 0 Paraquat-inducible protein A WD40 PF00400.32 EKE42634.1 - 1.3e-11 44.8 9.2 0.0079 17.0 0.0 5.7 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE42634.1 - 7e-06 26.3 0.0 0.0044 17.3 0.0 3.7 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EKE42634.1 - 0.022 15.3 1.4 8.1 7.1 0.4 3.1 3 0 0 3 3 3 0 PQQ-like domain Ge1_WD40 PF16529.5 EKE42634.1 - 0.026 13.5 0.0 1.1 8.1 0.0 2.8 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein MBOAT PF03062.19 EKE42636.1 - 9.7e-25 87.6 23.3 9.7e-25 87.6 23.3 2.5 1 1 2 3 3 3 1 MBOAT, membrane-bound O-acyltransferase family PsbI PF02532.14 EKE42636.1 - 6.8 6.7 11.3 0.086 12.8 1.7 3.0 2 0 0 2 2 2 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) BCAS2 PF05700.11 EKE42637.1 - 0.0056 16.4 3.3 0.0067 16.1 3.3 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) FERM_M PF00373.18 EKE42637.1 - 0.079 13.4 1.0 0.093 13.1 1.0 1.2 1 0 0 1 1 1 0 FERM central domain BBS2_N PF14781.6 EKE42637.1 - 0.093 12.6 0.2 0.1 12.5 0.2 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal DUF4199 PF13858.6 EKE42638.1 - 0.029 14.8 7.7 0.047 14.1 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) MgtE PF01769.16 EKE42638.1 - 0.067 13.6 10.4 1.4 9.3 6.7 2.1 2 0 0 2 2 2 0 Divalent cation transporter Adeno_E3B PF03376.14 EKE42638.1 - 0.93 9.8 16.1 4.6 7.6 1.1 3.2 2 1 1 3 3 3 0 Adenovirus E3B protein DUF2070 PF09843.9 EKE42638.1 - 2.3 6.4 8.9 2.7 6.2 8.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Tetraspanin PF00335.20 EKE42638.1 - 3.1 7.4 18.5 13 5.4 18.5 2.0 1 1 0 1 1 1 0 Tetraspanin family TEX29 PF15839.5 EKE42638.1 - 3.2 8.4 15.5 2.5 8.7 2.5 2.8 2 1 1 3 3 3 0 Testis-expressed sequence 29 protein DUF3177 PF11375.8 EKE42638.1 - 8 6.2 14.2 1.2e+03 -0.9 14.3 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3177) ABC2_membrane PF01061.24 EKE42639.1 - 3.6e-16 59.2 21.5 3.6e-16 59.2 21.5 1.6 2 0 0 2 2 2 1 ABC-2 type transporter His_Phos_2 PF00328.22 EKE42640.1 - 1.7e-12 47.4 1.3 4.9e-09 36.0 0.0 3.2 1 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 2) HTH_7 PF02796.15 EKE42640.1 - 0.067 13.3 0.1 1.7 8.7 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase Ribosomal_S5_C PF03719.15 EKE42640.1 - 0.07 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S5, C-terminal domain RhoGEF PF00621.20 EKE42641.1 - 2.5e-07 31.1 2.1 2.5e-07 31.1 2.1 3.2 2 1 0 3 3 3 1 RhoGEF domain Phi-29_GP3 PF05435.11 EKE42641.1 - 0.17 11.3 18.2 0.047 13.2 6.0 3.0 2 1 0 3 3 3 0 Phi-29 DNA terminal protein GP3 DUF3552 PF12072.8 EKE42641.1 - 3.8 6.9 53.5 0.11 11.9 20.2 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3552) Exonuc_VII_L PF02601.15 EKE42641.1 - 6.4 6.2 19.4 0.21 11.1 10.6 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit LisH PF08513.11 EKE42642.1 - 1.8e-06 27.7 0.1 4.3e-06 26.5 0.1 1.7 1 0 0 1 1 1 1 LisH SRP40_C PF05022.12 EKE42642.1 - 2.1e-06 28.5 6.9 2.1e-06 28.5 6.9 4.4 2 1 1 4 4 4 1 SRP40, C-terminal domain Mitofilin PF09731.9 EKE42642.1 - 1.1 8.0 52.0 1.4 7.7 52.0 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein LAP1C PF05609.12 EKE42642.1 - 4 6.4 33.0 5 6.1 33.0 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dapper PF15268.6 EKE42642.1 - 6.3 5.5 35.7 7.3 5.3 35.7 1.1 1 0 0 1 1 1 0 Dapper TLD PF07534.16 EKE42643.1 - 0.00035 20.8 1.2 0.00035 20.8 1.2 2.5 2 1 0 2 2 2 1 TLD HiaBD2 PF15403.6 EKE42643.1 - 0.05 14.0 0.2 0.13 12.7 0.2 1.6 1 0 0 1 1 1 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) DUF1053 PF06327.14 EKE42643.1 - 0.13 12.8 6.4 0.29 11.7 6.4 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) RICTOR_V PF14668.6 EKE42644.1 - 0.016 15.4 0.1 3.4 8.0 0.0 3.0 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 ETRAMP PF09716.10 EKE42644.1 - 0.057 13.5 1.3 0.16 12.1 0.3 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) PTS_2-RNA PF01885.16 EKE42645.1 - 9.4e-60 201.8 2.0 1.1e-59 201.6 2.0 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Cpn60_TCP1 PF00118.24 EKE42647.1 - 4.9e-149 497.1 16.5 5.6e-149 496.9 16.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DGC PF08859.11 EKE42647.1 - 0.3 11.2 4.4 0.44 10.7 1.6 2.7 2 1 0 2 2 2 0 DGC domain hDGE_amylase PF14701.6 EKE42648.1 - 3.9 6.5 12.6 4.2 6.4 12.6 1.0 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Lipoxygenase PF00305.19 EKE42648.1 - 4.4 5.6 14.3 0.56 8.6 3.9 2.0 1 1 0 2 2 2 0 Lipoxygenase Pkinase PF00069.25 EKE42649.1 - 6.2e-26 91.3 0.0 7.6e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42649.1 - 3.2e-13 49.6 0.0 3.4e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE42649.1 - 2.8e-08 33.0 0.1 3.5e-08 32.7 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKE42649.1 - 5.3e-08 33.1 0.1 1.4e-05 25.1 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EKE42649.1 - 0.00086 19.0 0.4 0.0029 17.2 0.1 1.6 1 1 0 2 2 2 1 RIO1 family Kdo PF06293.14 EKE42649.1 - 0.045 13.1 0.1 0.068 12.5 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.11 EKE42649.1 - 0.067 12.8 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) L_protein_N PF15518.6 EKE42649.1 - 0.076 12.9 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 L protein N-terminus Myb_DNA-binding PF00249.31 EKE42650.1 - 7.5e-32 109.3 4.4 1.2e-16 60.6 1.6 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE42650.1 - 3e-24 85.0 4.3 1.4e-16 60.5 0.7 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EKE42650.1 - 4.6e-08 32.9 0.6 0.0036 17.2 0.0 2.3 1 1 1 2 2 2 2 Myb DNA-binding like SLIDE PF09111.10 EKE42650.1 - 0.00015 21.8 0.1 0.016 15.2 0.0 2.2 2 0 0 2 2 2 1 SLIDE SANT_DAMP1_like PF16282.5 EKE42650.1 - 0.00097 19.3 0.2 0.32 11.2 0.0 2.6 1 1 1 2 2 2 2 SANT/Myb-like domain of DAMP1 MIP-T3 PF10243.9 EKE42650.1 - 0.037 14.0 0.0 0.093 12.7 0.0 1.7 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 CH-like domain Myb_DNA-bind_2 PF08914.11 EKE42650.1 - 0.078 13.2 1.3 0.59 10.4 0.1 2.8 1 1 2 3 3 3 0 Rap1 Myb domain Nop16 PF09420.10 EKE42651.1 - 1.1e-09 38.7 0.3 1.1e-09 38.7 0.3 2.5 2 1 0 2 2 1 1 Ribosome biogenesis protein Nop16 Paf1 PF03985.13 EKE42651.1 - 0.04 12.9 22.6 0.056 12.4 22.6 1.3 1 0 0 1 1 1 0 Paf1 SDA1 PF05285.12 EKE42651.1 - 0.058 12.8 27.7 0.067 12.6 27.7 1.1 1 0 0 1 1 1 0 SDA1 RR_TM4-6 PF06459.12 EKE42651.1 - 0.2 11.5 23.9 0.25 11.1 23.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 EKE42651.1 - 0.25 10.7 24.9 0.33 10.3 24.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 EKE42651.1 - 0.44 10.7 12.3 0.63 10.2 12.3 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 EKE42651.1 - 0.58 8.9 13.3 0.57 8.9 13.3 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 EKE42651.1 - 1.2 9.2 6.3 1.2 9.1 6.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EOS1 PF12326.8 EKE42651.1 - 1.2 9.1 2.9 1.4 8.8 2.9 1.4 1 0 0 1 1 1 0 N-glycosylation protein DUF913 PF06025.12 EKE42651.1 - 1.4 7.8 9.7 1.6 7.6 9.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Tim54 PF11711.8 EKE42651.1 - 2.7 6.7 23.6 4.3 6.0 23.6 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SID-1_RNA_chan PF13965.6 EKE42651.1 - 4.1 5.7 5.8 3.5 5.9 5.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 EKE42651.1 - 4.2 6.2 4.3 3.8 6.3 4.3 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Hid1 PF12722.7 EKE42651.1 - 4.7 5.2 14.0 4.8 5.2 14.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RP-C_C PF11800.8 EKE42651.1 - 5.9 6.9 11.4 9.7 6.2 11.4 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region RNA_polI_A34 PF08208.11 EKE42651.1 - 7.8 6.5 26.5 12 5.9 26.5 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RNA_pol_Rpc4 PF05132.14 EKE42651.1 - 8 6.9 17.7 15 6.0 17.7 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 RRP36 PF06102.12 EKE42652.1 - 1.1e-28 100.3 24.5 1.4e-28 99.9 24.5 1.0 1 0 0 1 1 1 1 rRNA biogenesis protein RRP36 Nif11 PF07862.11 EKE42652.1 - 0.096 13.0 1.4 0.21 11.9 0.4 2.1 2 0 0 2 2 2 0 Nif11 domain DUF3287 PF11690.8 EKE42652.1 - 1.3 8.8 9.0 0.038 13.7 1.8 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3287) VCBS PF13517.6 EKE42653.1 - 2.7e-08 34.3 1.8 0.69 10.6 0.0 4.1 3 1 2 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PQQ_2 PF13360.6 EKE42653.1 - 0.0038 16.8 0.0 9.5 5.7 0.0 3.8 4 0 0 4 4 4 2 PQQ-like domain FG-GAP PF01839.23 EKE42653.1 - 0.84 9.8 21.0 0.2 11.8 0.4 4.3 5 0 0 5 5 5 0 FG-GAP repeat LRR_adjacent PF08191.11 EKE42654.1 - 0.08 13.2 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 LRR adjacent Gelsolin PF00626.22 EKE42655.1 - 2.2e-19 69.1 1.0 9.1e-09 35.1 0.0 4.4 4 0 0 4 4 4 3 Gelsolin repeat VHP PF02209.19 EKE42655.1 - 4.9e-12 45.7 0.7 4.9e-12 45.7 0.7 2.9 3 0 0 3 3 3 1 Villin headpiece domain Not1 PF04054.15 EKE42655.1 - 0.069 12.1 3.0 0.13 11.1 3.0 1.4 1 0 0 1 1 1 0 CCR4-Not complex component, Not1 ATP-synt_F PF01990.17 EKE42656.1 - 4.4e-27 94.2 0.1 5.5e-27 93.9 0.1 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit eIF-5_eIF-2B PF01873.17 EKE42656.1 - 0.086 12.7 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain found in IF2B/IF5 DUF5305 PF17231.2 EKE42657.1 - 0.0015 18.0 3.6 0.0033 16.9 3.6 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Podoplanin PF05808.11 EKE42657.1 - 0.0068 16.5 1.5 0.016 15.3 1.5 1.7 1 0 0 1 1 1 1 Podoplanin DUF4064 PF13273.6 EKE42657.1 - 0.0086 16.3 1.1 0.0086 16.3 1.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4064) Rax2 PF12768.7 EKE42657.1 - 0.027 13.9 0.2 0.043 13.3 0.2 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity TMEM132D_C PF15706.5 EKE42657.1 - 0.028 14.2 0.0 0.61 9.9 0.0 2.3 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Ank_2 PF12796.7 EKE42658.1 - 9.7e-17 61.3 0.4 3.7e-14 53.1 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EKE42658.1 - 1.4e-14 53.9 0.7 2.2e-07 31.0 0.0 3.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EKE42658.1 - 2e-14 53.8 0.3 1.2e-08 35.3 0.0 3.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EKE42658.1 - 3.9e-13 49.2 0.3 3.2e-05 24.2 0.0 3.9 3 1 1 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EKE42658.1 - 4e-09 36.0 0.1 0.0061 17.0 0.0 4.4 4 1 0 4 4 4 2 Ankyrin repeat DUF2492 PF10678.9 EKE42658.1 - 0.016 15.5 0.2 0.055 13.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2492) TLD PF07534.16 EKE42659.1 - 2e-05 24.8 0.2 4.6e-05 23.7 0.2 1.6 1 0 0 1 1 1 1 TLD SapB_2 PF03489.17 EKE42660.1 - 7.9e-07 29.1 0.7 1.8e-06 27.9 0.7 1.6 1 0 0 1 1 1 1 Saposin-like type B, region 2 SapB_1 PF05184.15 EKE42660.1 - 0.006 16.6 0.5 0.006 16.6 0.5 2.6 2 1 0 2 2 2 1 Saposin-like type B, region 1 RhoGEF PF00621.20 EKE42662.1 - 1e-22 81.3 1.3 4.1e-22 79.3 1.3 2.1 1 0 0 1 1 1 1 RhoGEF domain MRP-L28 PF09812.9 EKE42662.1 - 6.5 6.9 17.8 0.73 10.0 13.2 1.7 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 WD40 PF00400.32 EKE42663.1 - 1.1e-09 38.7 2.4 0.0042 17.9 0.2 4.6 4 1 0 4 4 4 3 WD domain, G-beta repeat BBS2_Mid PF14783.6 EKE42663.1 - 0.0083 16.1 0.1 0.046 13.8 0.0 2.3 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region DUF5640 PF18692.1 EKE42663.1 - 0.075 13.1 0.1 0.21 11.7 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5640) HEAT PF02985.22 EKE42664.1 - 5.2e-14 51.1 0.6 0.13 12.6 0.0 6.8 6 0 0 6 6 5 4 HEAT repeat HEAT_EZ PF13513.6 EKE42664.1 - 8.3e-10 39.0 0.1 0.0038 17.7 0.0 5.7 6 1 1 7 7 7 2 HEAT-like repeat HEAT_2 PF13646.6 EKE42664.1 - 4.1e-06 27.1 0.0 0.013 15.9 0.0 4.3 3 1 1 4 4 4 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EKE42664.1 - 8.9e-06 26.2 5.6 0.0017 18.9 0.1 4.9 4 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EKE42664.1 - 1.1e-05 24.2 14.4 5e-05 22.1 0.1 4.9 5 1 1 6 6 6 2 Adaptin N terminal region B56 PF01603.20 EKE42664.1 - 5.1e-05 22.4 0.7 0.0037 16.3 0.0 3.3 2 1 0 2 2 2 1 Protein phosphatase 2A regulatory B subunit (B56 family) V-ATPase_H_C PF11698.8 EKE42664.1 - 0.00016 21.8 3.3 0.086 13.0 0.1 4.0 4 0 0 4 4 4 1 V-ATPase subunit H CLASP_N PF12348.8 EKE42664.1 - 0.0041 16.7 2.8 0.036 13.6 0.1 3.3 2 2 1 3 3 3 1 CLASP N terminal TetR_C_19 PF17924.1 EKE42664.1 - 0.058 14.0 0.7 0.29 11.7 0.2 2.4 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF4354 PF14263.6 EKE42664.1 - 0.13 12.0 0.0 0.34 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4354) Arm PF00514.23 EKE42664.1 - 0.15 12.2 4.2 18 5.6 0.0 4.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat TIP120 PF08623.10 EKE42664.1 - 0.63 9.8 3.8 4.8 6.9 0.1 3.5 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) Cullin PF00888.22 EKE42665.1 - 8e-21 74.3 27.9 9.5e-21 74.1 22.1 2.4 2 1 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EKE42665.1 - 9.1e-19 67.3 6.6 9.1e-19 67.3 6.6 4.6 3 1 1 4 4 4 1 Cullin protein neddylation domain DUF61 PF01886.16 EKE42665.1 - 0.011 15.8 0.7 0.011 15.8 0.7 3.3 4 0 0 4 4 4 0 Protein of unknown function DUF61 Exo_endo_phos PF03372.23 EKE42666.1 - 0.02 14.4 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Beach PF02138.18 EKE42667.1 - 5e-106 354.1 5.5 1.4e-105 352.7 5.5 1.9 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EKE42667.1 - 1e-10 41.6 0.2 4.5e-10 39.5 0.2 2.2 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH ANAPC4_WD40 PF12894.7 EKE42667.1 - 0.0012 19.0 0.1 2.1 8.7 0.0 2.9 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Laminin_G_3 PF13385.6 EKE42667.1 - 0.099 12.8 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily COX6B PF02297.17 EKE42667.1 - 0.15 12.3 0.4 0.45 10.8 0.4 1.8 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb Ku_PK_bind PF08785.11 EKE42667.1 - 7.6 6.7 11.0 0.14 12.3 0.9 3.4 4 0 0 4 4 4 0 Ku C terminal domain like Ribophorin_II PF05817.14 EKE42668.1 - 0.00013 20.7 19.9 0.00015 20.5 19.9 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II DUF3810 PF12725.7 EKE42668.1 - 9.2 5.5 7.6 11 5.2 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Ras PF00071.22 EKE42669.1 - 7.3e-49 165.5 0.3 1e-48 165.0 0.3 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42669.1 - 1.1e-27 96.7 0.1 2.1e-27 95.7 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42669.1 - 2.8e-12 46.4 1.7 4e-11 42.7 0.1 2.0 1 1 1 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 EKE42669.1 - 9.6e-06 25.1 0.4 2.1e-05 24.0 0.1 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EKE42669.1 - 2.9e-05 24.1 0.0 7.6e-05 22.8 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EKE42669.1 - 0.00011 21.6 0.0 0.00014 21.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EKE42669.1 - 0.00014 21.4 0.1 0.0041 16.7 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CTP_transf_3 PF02348.19 EKE42669.1 - 0.0028 17.6 0.0 0.0044 17.0 0.0 1.3 1 1 0 1 1 1 1 Cytidylyltransferase Lact_bio_phlase PF09508.10 EKE42669.1 - 0.013 14.0 0.4 0.045 12.2 0.3 1.8 1 1 1 2 2 2 0 Lacto-N-biose phosphorylase N-terminal TIM barrel domain FeoB_N PF02421.18 EKE42669.1 - 0.014 14.9 0.0 0.26 10.8 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF1681 PF07933.14 EKE42670.1 - 5e-35 120.4 0.3 9.4e-35 119.5 0.0 1.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1681) Caskin-tail PF16632.5 EKE42670.1 - 0.091 13.2 0.9 0.4 11.1 0.1 2.3 2 0 0 2 2 2 0 C-terminal region of Caskin Pmp3 PF01679.17 EKE42672.1 - 4.2e-18 65.3 16.8 4.8e-18 65.1 16.8 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF872 PF05915.12 EKE42672.1 - 0.033 14.4 4.0 0.039 14.1 4.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) DUF3975 PF13126.6 EKE42672.1 - 0.082 13.4 5.0 0.086 13.3 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3975) MpPF26 PF07666.11 EKE42672.1 - 3 8.0 11.7 3.9 7.6 5.5 2.0 1 1 1 2 2 2 0 M penetrans paralogue family 26 FH2 PF02181.23 EKE42673.1 - 2.3e-24 86.2 0.2 2.3e-24 86.2 0.2 4.2 4 0 0 4 4 4 3 Formin Homology 2 Domain LRR_8 PF13855.6 EKE42674.1 - 2.3e-38 129.7 53.5 1.1e-08 34.7 1.3 8.4 5 2 2 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EKE42674.1 - 6.8e-34 115.3 75.8 1.3e-07 31.8 2.4 10.3 3 3 9 13 13 13 12 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EKE42674.1 - 2.5e-06 27.2 56.3 2.1 9.2 0.0 15.0 15 2 2 17 17 17 6 Leucine Rich Repeat LRR_9 PF14580.6 EKE42674.1 - 3.8e-06 26.5 33.0 0.016 14.7 0.8 5.3 1 1 3 5 5 5 3 Leucine-rich repeat RsmF_methylt_CI PF17126.5 EKE42674.1 - 0.013 15.5 0.3 5.9 7.0 0.0 4.8 5 1 2 7 7 7 0 RsmF rRNA methyltransferase first C-terminal domain LRR_5 PF13306.6 EKE42674.1 - 0.28 11.2 17.3 2.4 8.1 3.7 3.5 2 2 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) CSTF_C PF14304.6 EKE42674.1 - 3.2 7.4 7.6 39 3.9 0.1 4.5 4 0 0 4 4 4 0 Transcription termination and cleavage factor C-terminal Peptidase_M22 PF00814.25 EKE42675.1 - 3.6e-87 292.5 0.1 4.2e-87 292.3 0.1 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 EKE42675.1 - 0.091 12.4 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus Pex16 PF08610.10 EKE42676.1 - 5.5e-05 22.5 0.0 0.00011 21.4 0.0 1.4 1 1 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Chorein_N PF12624.7 EKE42677.1 - 5.3e-33 113.6 0.1 3.5e-32 111.0 0.1 2.6 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EKE42677.1 - 9.8e-31 107.4 17.2 2.9e-29 102.5 5.5 5.4 5 0 0 5 5 5 3 Vacuolar sorting-associated protein 13, N-terminal TAF4 PF05236.14 EKE42678.1 - 0.0085 15.9 0.0 0.011 15.5 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Sec7 PF01369.20 EKE42679.1 - 1.3e-39 135.8 4.5 1.6e-39 135.5 0.0 3.2 4 0 0 4 4 4 1 Sec7 domain Sec7_N PF12783.7 EKE42679.1 - 5.2e-13 49.2 6.0 5.2e-13 49.2 6.0 4.1 5 0 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EKE42679.1 - 6.2e-10 38.8 0.2 6.2e-10 38.8 0.2 4.4 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) RhoGAP PF00620.27 EKE42679.1 - 0.037 13.9 0.3 0.24 11.2 0.3 2.5 1 0 0 1 1 1 0 RhoGAP domain Cohesin_HEAT PF12765.7 EKE42679.1 - 0.12 12.8 0.1 0.52 10.7 0.0 2.2 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Yos1 PF08571.10 EKE42679.1 - 4.4 7.7 5.8 0.8 10.0 0.3 2.7 3 0 0 3 3 3 0 Yos1-like LRR_5 PF13306.6 EKE42680.1 - 8.4e-69 229.4 26.2 1.3e-31 109.3 3.2 3.6 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE42680.1 - 1.1e-11 44.3 0.2 0.0089 15.8 0.1 5.4 3 2 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EKE42680.1 - 0.00084 19.7 3.9 0.76 10.3 0.3 4.4 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) Med14 PF08638.11 EKE42681.1 - 4.3e-05 23.0 0.2 0.00022 20.7 0.2 2.1 1 1 0 1 1 1 1 Mediator complex subunit MED14 Crystall PF00030.19 EKE42681.1 - 0.55 10.5 4.7 39 4.6 0.1 3.4 3 0 0 3 3 3 0 Beta/Gamma crystallin PFU PF09070.11 EKE42682.1 - 1.5e-11 44.5 0.5 5.7e-11 42.7 0.0 2.1 2 1 1 3 3 3 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 EKE42682.1 - 7.9e-07 28.6 0.3 1e-06 28.3 0.3 1.2 1 0 0 1 1 1 1 PUL domain SAT PF16073.5 EKE42682.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis DUF5497 PF17601.2 EKE42683.1 - 0.73 10.2 6.2 7.1 7.0 0.5 3.2 2 0 0 2 2 2 0 Family of unknown function (DUF5497) GCV_H PF01597.19 EKE42684.1 - 0.12 12.3 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein DTW PF03942.15 EKE42686.1 - 1.7e-28 99.7 0.0 2.1e-28 99.4 0.0 1.0 1 0 0 1 1 1 1 DTW domain Dynactin_p22 PF07426.11 EKE42686.1 - 0.014 15.3 0.2 0.02 14.8 0.2 1.4 1 1 0 1 1 1 0 Dynactin subunit p22 SDA1 PF05285.12 EKE42687.1 - 1.5e-35 123.3 55.0 1.5e-35 123.3 55.0 2.8 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 EKE42687.1 - 6.8e-05 23.1 0.6 0.00018 21.7 0.0 2.1 2 0 0 2 2 2 1 NUC130/3NT domain INTS5_N PF14837.6 EKE42687.1 - 0.038 13.6 0.4 0.08 12.5 0.4 1.6 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus DUF2153 PF09921.9 EKE42687.1 - 0.12 12.1 2.9 1.8 8.4 0.2 3.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2153) Gelsolin PF00626.22 EKE42689.1 - 1.4e-29 101.8 5.5 5.8e-09 35.7 0.0 7.2 6 0 0 6 6 6 6 Gelsolin repeat PHD_4 PF16866.5 EKE42689.1 - 0.11 12.7 1.5 0.7 10.0 1.5 2.6 1 0 0 1 1 1 0 PHD-finger AAA_14 PF13173.6 EKE42689.1 - 9.3 6.3 9.7 1.2 9.2 3.2 3.1 2 0 0 2 2 2 0 AAA domain TrkH PF02386.16 EKE42690.1 - 1.7e-60 204.9 26.3 1e-59 202.4 22.9 2.4 1 1 1 2 2 2 2 Cation transport protein Peptidase_M56 PF05569.11 EKE42690.1 - 0.035 13.3 1.7 0.09 12.0 0.6 2.1 2 0 0 2 2 2 0 BlaR1 peptidase M56 DUF4538 PF15061.6 EKE42690.1 - 0.86 9.4 4.7 2.1 8.1 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4538) Pkinase PF00069.25 EKE42691.1 - 8.2e-58 195.8 1.7 1.8e-57 194.7 1.7 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42691.1 - 3.9e-39 134.5 1.1 1.2e-38 132.8 1.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EKE42691.1 - 1.1e-11 44.9 0.4 3e-11 43.5 0.4 1.9 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 EKE42691.1 - 0.00018 20.9 0.0 0.0003 20.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Yop-YscD_cpl PF16697.5 EKE42691.1 - 0.00031 21.0 0.0 0.00074 19.8 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 EKE42691.1 - 0.0015 17.4 0.5 0.0042 15.9 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase UPF0302 PF08864.10 EKE42691.1 - 0.014 15.4 0.1 0.084 12.9 0.1 2.3 1 1 0 1 1 1 0 UPF0302 domain APH PF01636.23 EKE42691.1 - 0.041 13.8 0.0 0.11 12.5 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ras PF00071.22 EKE42692.1 - 2.9e-08 33.5 0.9 5.9e-08 32.5 0.9 1.5 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EKE42692.1 - 0.0061 16.6 0.2 0.018 15.1 0.2 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EKE42692.1 - 0.028 14.6 0.1 0.13 12.4 0.1 2.2 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EKE42692.1 - 0.035 13.8 0.5 0.4 10.4 0.5 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Diphthamide_syn PF01866.17 EKE42693.1 - 5e-78 262.6 0.0 6e-78 262.3 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein TetR_C_4 PF08359.11 EKE42693.1 - 0.11 12.6 0.1 6.7 6.9 0.1 2.3 2 0 0 2 2 2 0 YsiA-like protein, C-terminal region Prefoldin_2 PF01920.20 EKE42694.1 - 1e-10 41.5 8.4 1.1e-10 41.4 8.4 1.0 1 0 0 1 1 1 1 Prefoldin subunit ABC_tran_CTD PF16326.5 EKE42694.1 - 6.9e-05 23.0 3.0 0.033 14.4 0.1 2.2 1 1 1 2 2 2 2 ABC transporter C-terminal domain Plasmid_RAQPRD PF09686.10 EKE42694.1 - 0.01 16.1 0.7 0.12 12.6 0.0 2.1 1 1 1 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) DUF5082 PF16888.5 EKE42694.1 - 0.037 14.3 5.7 0.065 13.5 0.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) XhlA PF10779.9 EKE42694.1 - 0.051 13.8 9.9 0.053 13.7 6.7 2.0 2 0 0 2 2 2 0 Haemolysin XhlA Spc24 PF08286.11 EKE42694.1 - 0.054 13.7 6.6 0.78 10.0 2.7 2.1 1 1 0 2 2 2 0 Spc24 subunit of Ndc80 Rx_N PF18052.1 EKE42694.1 - 0.064 13.5 2.2 4.6 7.6 0.0 2.1 2 0 0 2 2 2 0 Rx N-terminal domain Syntaxin_2 PF14523.6 EKE42694.1 - 0.13 12.7 6.3 0.86 10.0 3.3 2.4 2 1 0 2 2 2 0 Syntaxin-like protein Occludin_ELL PF07303.13 EKE42694.1 - 0.17 12.6 6.3 0.26 12.0 4.8 1.8 1 1 1 2 2 2 0 Occludin homology domain STAT_alpha PF01017.20 EKE42694.1 - 0.19 11.6 6.2 0.23 11.3 6.2 1.2 1 0 0 1 1 1 0 STAT protein, all-alpha domain V_ATPase_I PF01496.19 EKE42694.1 - 0.47 8.3 5.7 0.49 8.3 5.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.10 EKE42694.1 - 1.4 9.1 7.1 2.3 8.4 7.1 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family CC2-LZ PF16516.5 EKE42694.1 - 1.6 9.2 9.0 3 8.3 3.4 2.1 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator CH PF00307.31 EKE42695.1 - 4e-21 75.2 2.2 6.6e-11 42.4 0.5 4.7 4 1 1 5 5 5 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EKE42695.1 - 3.4e-07 30.0 1.9 0.018 14.9 0.0 3.2 4 0 0 4 4 4 2 CAMSAP CH domain CH_2 PF06294.11 EKE42695.1 - 0.00051 20.1 1.9 0.0047 17.0 0.1 3.7 3 0 0 3 3 3 1 CH-like domain in sperm protein 2-ph_phosp PF04029.14 EKE42696.1 - 1.2e-45 155.4 0.0 6.6e-45 153.0 0.0 1.8 1 1 0 1 1 1 1 2-phosphosulpholactate phosphatase RhoGAP PF00620.27 EKE42697.1 - 1.4e-23 83.4 0.5 1.4e-23 83.4 0.5 2.0 2 1 0 2 2 2 1 RhoGAP domain Muted PF14942.6 EKE42697.1 - 0.0082 16.5 3.7 0.0082 16.5 3.7 2.0 1 1 0 1 1 1 1 Organelle biogenesis, Muted-like protein SAC3_GANP PF03399.16 EKE42698.1 - 6.7e-15 55.2 7.3 1.1e-08 34.8 0.7 2.6 2 1 1 3 3 3 2 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EKE42698.1 - 0.0019 18.2 0.0 0.0058 16.6 0.0 1.8 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family MalF_P2 PF14785.6 EKE42698.1 - 0.11 12.6 1.7 0.44 10.5 0.0 2.4 2 0 0 2 2 2 0 Maltose transport system permease protein MalF P2 domain RhoGEF PF00621.20 EKE42699.1 - 5.5e-33 114.7 1.8 2.7e-32 112.5 1.8 2.3 1 0 0 1 1 1 1 RhoGEF domain DUF5333 PF17267.2 EKE42699.1 - 0.045 13.9 0.3 0.17 12.1 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5333) Peptidase_S9 PF00326.21 EKE42701.1 - 4.2e-19 68.9 0.0 7.4e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EKE42701.1 - 0.0013 18.1 0.0 0.25 10.6 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 EKE42701.1 - 0.0015 18.2 0.0 0.018 14.6 0.0 2.3 1 1 0 1 1 1 1 Dienelactone hydrolase family Pkinase PF00069.25 EKE42702.1 - 2.7e-08 33.5 0.2 4.6e-07 29.5 0.2 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42702.1 - 1.4e-06 27.8 0.0 9.8e-06 25.0 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase DAGK_acc PF00609.19 EKE42703.1 - 3.4e-40 138.0 0.0 5.3e-40 137.4 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 EKE42703.1 - 2.3e-19 69.3 0.0 3.8e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 EKE42703.1 - 2.3e-16 59.4 36.9 8.9e-07 28.7 5.9 3.4 3 0 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EKE42703.1 - 4e-07 30.2 29.7 0.001 19.4 4.5 3.5 3 0 0 3 3 3 3 C1 domain Zf_RING PF16744.5 EKE42703.1 - 0.0013 18.8 2.8 0.0013 18.8 2.8 3.4 3 0 0 3 3 3 1 KIAA1045 RING finger Ras PF00071.22 EKE42704.1 - 4.8e-08 32.8 0.9 6.5e-07 29.1 0.9 2.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EKE42704.1 - 8.6e-07 29.2 0.1 6e-06 26.5 0.1 2.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EKE42704.1 - 1.6e-05 25.0 0.5 5.2e-05 23.3 0.1 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EKE42704.1 - 0.00053 19.5 1.4 0.00078 19.0 0.1 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.10 EKE42704.1 - 0.0027 17.1 0.0 0.0079 15.7 0.0 1.8 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EKE42704.1 - 0.013 15.4 0.8 0.013 15.4 0.8 2.1 2 1 1 3 3 3 0 RsgA GTPase CDP-OH_P_transf PF01066.21 EKE42708.1 - 2.4e-17 63.5 0.1 2.4e-17 63.5 0.1 4.1 3 2 0 3 3 3 1 CDP-alcohol phosphatidyltransferase DUF900 PF05990.12 EKE42709.1 - 9.8e-26 90.7 0.0 1.8e-25 89.8 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DUF3488 PF11992.8 EKE42709.1 - 1.8 7.4 7.8 2.8 6.8 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) DUF2070 PF09843.9 EKE42709.1 - 7 4.8 10.3 11 4.2 10.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Ras PF00071.22 EKE42710.1 - 6.3e-52 175.4 0.2 7.5e-52 175.2 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42710.1 - 5.4e-35 120.2 0.1 7.6e-35 119.7 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42710.1 - 1.9e-20 73.0 0.1 2.6e-20 72.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EKE42710.1 - 3.9e-06 26.6 0.1 3.5e-05 23.4 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EKE42710.1 - 8.5e-05 22.6 0.0 0.00015 21.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EKE42710.1 - 0.00013 21.5 0.1 0.00063 19.2 0.0 2.0 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EKE42710.1 - 0.00027 20.4 0.1 0.00032 20.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EKE42710.1 - 0.0023 17.7 0.1 0.023 14.4 0.1 2.0 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EKE42710.1 - 0.0044 16.5 0.0 0.0088 15.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_7 PF12775.7 EKE42710.1 - 0.0073 15.8 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EKE42710.1 - 0.009 15.9 0.0 4.2 7.3 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase Septin PF00735.18 EKE42710.1 - 0.015 14.6 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Septin FeoB_N PF02421.18 EKE42710.1 - 0.023 14.2 0.0 0.059 12.9 0.0 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.6 EKE42710.1 - 0.071 13.5 0.0 0.13 12.6 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EKE42710.1 - 0.1 12.9 0.0 0.17 12.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain SH3_2 PF07653.17 EKE42711.1 - 2.3e-30 104.1 1.2 1.5e-06 27.8 0.0 6.2 6 0 0 6 6 6 5 Variant SH3 domain SH3_9 PF14604.6 EKE42711.1 - 1.4e-29 101.7 0.4 5.4e-07 29.4 0.1 6.2 6 0 0 6 6 6 5 Variant SH3 domain SH3_1 PF00018.28 EKE42711.1 - 1.9e-28 97.8 2.5 0.00016 21.2 0.0 6.2 6 0 0 6 6 6 5 SH3 domain Pet100 PF09803.9 EKE42711.1 - 2.2 8.9 7.7 8.8 6.9 4.1 2.6 1 1 1 2 2 2 0 Pet100 Ala_racemase_N PF01168.20 EKE42712.1 - 3.1e-28 98.9 0.1 3.7e-28 98.7 0.1 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain MIB_HERC2 PF06701.13 EKE42715.1 - 2e-35 120.9 33.4 1.4e-17 63.7 10.9 2.3 2 0 0 2 2 2 2 Mib_herc2 SH3_15 PF18346.1 EKE42715.1 - 0.0045 17.3 11.2 0.014 15.7 1.1 2.4 2 0 0 2 2 2 2 Mind bomb SH3 repeat domain AAA PF00004.29 EKE42717.1 - 7.3e-41 139.7 0.1 1.9e-38 131.9 0.0 3.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EKE42717.1 - 9e-06 26.0 0.2 0.0046 17.2 0.1 3.7 1 1 2 3 3 3 1 AAA domain AAA_7 PF12775.7 EKE42717.1 - 2.8e-05 23.7 0.1 0.0002 20.9 0.1 2.3 1 1 0 1 1 1 1 P-loop containing dynein motor region RuvB_N PF05496.12 EKE42717.1 - 3.7e-05 23.5 0.0 0.0003 20.6 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EKE42717.1 - 4.5e-05 23.5 0.4 0.0029 17.6 0.1 3.4 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EKE42717.1 - 0.00028 20.6 0.0 0.00075 19.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EKE42717.1 - 0.00046 20.6 0.1 0.0025 18.2 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 EKE42717.1 - 0.00092 19.0 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EKE42717.1 - 0.00098 19.2 2.8 0.028 14.4 0.0 4.0 4 1 0 4 4 4 1 AAA domain Mg_chelatase PF01078.21 EKE42717.1 - 0.0012 18.3 0.1 0.0027 17.1 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EKE42717.1 - 0.0031 17.7 0.2 0.044 13.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Bac_DnaA PF00308.18 EKE42717.1 - 0.0041 17.0 0.0 0.0099 15.7 0.0 1.6 1 0 0 1 1 1 1 Bacterial dnaA protein DUF815 PF05673.13 EKE42717.1 - 0.0043 16.3 0.0 0.01 15.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EKE42717.1 - 0.0044 17.6 0.0 0.02 15.5 0.0 2.2 2 0 0 2 2 1 1 AAA domain Sigma54_activat PF00158.26 EKE42717.1 - 0.015 15.0 0.0 0.053 13.2 0.0 2.0 2 1 0 2 2 1 0 Sigma-54 interaction domain TIP49 PF06068.13 EKE42717.1 - 0.018 14.3 4.4 0.026 13.7 0.1 2.7 2 1 0 2 2 2 0 TIP49 P-loop domain AAA_33 PF13671.6 EKE42717.1 - 0.022 14.9 0.0 0.058 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EKE42717.1 - 0.023 14.4 0.1 0.092 12.5 0.1 2.1 1 1 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 EKE42717.1 - 0.031 13.9 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain FHA PF00498.26 EKE42717.1 - 0.034 14.5 0.0 0.15 12.4 0.0 2.1 2 0 0 2 2 2 0 FHA domain PhoH PF02562.16 EKE42717.1 - 0.048 13.1 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.22 EKE42717.1 - 0.12 12.8 0.0 0.51 10.8 0.0 2.2 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EKE42717.1 - 0.13 12.1 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 EKE42717.1 - 0.18 11.3 0.4 0.45 10.1 0.3 1.6 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EKE42717.1 - 0.2 11.4 0.1 0.42 10.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain tRNA_U5-meth_tr PF05958.11 EKE42718.1 - 3.3e-24 85.5 0.9 1.6e-22 80.0 0.6 2.6 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EKE42718.1 - 2e-09 37.4 0.0 5.3e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EKE42718.1 - 2e-07 30.7 0.0 3.9e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EKE42718.1 - 1.7e-06 28.6 0.0 4e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EKE42718.1 - 7.4e-05 22.4 0.1 0.00037 20.1 0.0 2.2 3 0 0 3 3 3 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 EKE42718.1 - 0.00015 22.4 0.0 0.00035 21.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EKE42718.1 - 0.0027 17.2 0.0 0.0074 15.7 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) N6_N4_Mtase PF01555.18 EKE42718.1 - 0.0069 16.1 0.1 0.022 14.5 0.0 1.9 2 0 0 2 2 2 1 DNA methylase NodS PF05401.11 EKE42718.1 - 0.016 14.8 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) DUF4322 PF14210.6 EKE42718.1 - 0.03 14.2 0.5 0.12 12.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4322) Methyltransf_32 PF13679.6 EKE42718.1 - 0.052 13.5 0.4 0.2 11.7 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 EKE42718.1 - 0.058 14.1 0.0 0.15 12.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EKE42718.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 EKE42718.1 - 0.14 11.8 1.3 1.3 8.7 1.3 2.1 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 PGI PF00342.19 EKE42719.1 - 1.2e-233 776.1 1.7 1.4e-233 775.9 1.7 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase ComR_TPR PF18710.1 EKE42719.1 - 0.0065 16.1 2.3 0.012 15.2 2.3 1.3 1 0 0 1 1 1 1 ComR tetratricopeptide OrsD PF12013.8 EKE42720.1 - 0.079 13.4 0.7 0.17 12.3 0.7 1.6 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D SH3_9 PF14604.6 EKE42721.1 - 4.6e-16 58.4 0.6 9.3e-16 57.4 0.6 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EKE42721.1 - 7.7e-16 57.4 0.5 1.4e-15 56.6 0.5 1.5 1 0 0 1 1 1 1 SH3 domain BAR PF03114.18 EKE42721.1 - 1.1e-14 54.7 0.0 1.5e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 BAR domain SH3_2 PF07653.17 EKE42721.1 - 2.8e-13 49.3 0.1 4.9e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain Med3 PF11593.8 EKE42721.1 - 0.0039 16.4 0.0 0.0076 15.5 0.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal POT1 PF02765.17 EKE42721.1 - 0.075 12.9 0.6 0.23 11.3 0.6 1.8 1 0 0 1 1 1 0 Telomeric single stranded DNA binding POT1/CDC13 TMEM234 PF10639.9 EKE42722.1 - 0.028 14.4 1.2 0.043 13.8 1.2 1.3 1 1 0 1 1 1 0 Putative transmembrane family 234 EamA PF00892.20 EKE42722.1 - 0.18 12.0 12.6 0.41 10.8 12.6 1.6 1 1 0 1 1 1 0 EamA-like transporter family NPL PF17800.1 EKE42723.1 - 0.0096 16.5 0.0 0.011 16.3 0.0 1.1 1 0 0 1 1 1 1 Nucleoplasmin-like domain Peptidase_M60_C PF18630.1 EKE42723.1 - 0.027 14.6 0.0 0.056 13.6 0.0 1.5 1 0 0 1 1 1 0 Peptidase M60 C-terminal domain Caudo_bapla_RBP PF08931.10 EKE42723.1 - 0.07 12.6 0.0 0.083 12.3 0.0 1.1 1 0 0 1 1 1 0 Receptor-binding protein of phage tail base-plate Siphoviridae, head ATP-synt_ab PF00006.25 EKE42724.1 - 1.9e-103 344.7 0.0 3e-103 344.0 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EKE42724.1 - 7.4e-48 161.4 0.0 1.3e-47 160.6 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EKE42724.1 - 5.1e-14 52.6 2.3 1.3e-13 51.3 2.3 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RnfC_N PF13375.6 EKE42724.1 - 0.0048 16.8 0.3 0.22 11.5 0.0 2.6 3 0 0 3 3 3 1 RnfC Barrel sandwich hybrid domain ATP-sulfurylase PF01747.17 EKE42725.1 - 1.1e-82 276.7 0.0 1.5e-82 276.2 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 EKE42725.1 - 1.6e-57 193.6 0.0 2.4e-57 193.1 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain Carm_PH PF17888.1 EKE42726.1 - 3.2e-05 24.2 2.1 8.8e-05 22.8 0.8 2.4 2 0 0 2 2 2 1 Carmil pleckstrin homology domain LRR_6 PF13516.6 EKE42726.1 - 0.00018 21.3 24.9 1.1 9.5 0.1 7.9 8 0 0 8 8 8 4 Leucine Rich repeat Myosin_TH1 PF06017.13 EKE42726.1 - 0.00044 20.0 3.1 0.0059 16.3 0.5 2.7 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding bPH_3 PF14470.6 EKE42726.1 - 0.14 12.5 3.6 0.17 12.3 0.8 2.6 2 0 0 2 2 2 0 Bacterial PH domain LRR_4 PF12799.7 EKE42726.1 - 0.4 11.2 28.0 0.96 10.0 0.9 6.6 3 2 4 7 7 7 0 Leucine Rich repeats (2 copies) adh_short PF00106.25 EKE42727.1 - 4.2e-22 78.6 0.0 5.6e-22 78.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EKE42727.1 - 4.1e-13 49.4 0.0 5.5e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EKE42727.1 - 0.0015 18.1 0.0 0.0019 17.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EKE42727.1 - 0.0067 15.9 0.1 0.0094 15.4 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase ELYS-bb PF16687.5 EKE42727.1 - 0.0088 14.7 0.0 0.012 14.2 0.0 1.1 1 0 0 1 1 1 1 beta-propeller of ELYS nucleoporin KR PF08659.10 EKE42727.1 - 0.01 15.8 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 KR domain Wax2_C PF12076.8 EKE42727.1 - 0.017 14.8 0.1 0.032 14.0 0.1 1.5 1 0 0 1 1 1 0 WAX2 C-terminal domain EF-hand_1 PF00036.32 EKE42728.1 - 2.2e-11 42.5 0.2 0.00032 20.0 0.1 2.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EKE42728.1 - 1.7e-10 40.0 1.7 0.00012 21.7 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EKE42728.1 - 1.3e-09 38.4 0.8 0.00085 19.7 0.1 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EKE42728.1 - 7.2e-07 29.0 1.5 0.0027 17.5 0.2 3.3 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EKE42728.1 - 5.1e-06 25.7 0.1 0.0032 16.9 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 EKE42728.1 - 0.0047 16.8 0.3 2.7 8.0 0.0 2.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Metallophos PF00149.28 EKE42729.1 - 3.6e-11 44.0 1.5 5.5e-11 43.4 1.1 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EKE42729.1 - 0.00022 21.5 0.2 0.012 15.8 0.2 3.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ras PF00071.22 EKE42730.1 - 1e-49 168.3 0.0 1.2e-49 168.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42730.1 - 6.1e-31 107.1 0.0 8.9e-31 106.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42730.1 - 3.2e-13 49.5 0.0 3.8e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EKE42730.1 - 4.4e-08 33.2 0.0 6.3e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EKE42730.1 - 1.3e-06 28.1 0.0 1e-05 25.2 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EKE42730.1 - 5.2e-06 26.5 0.0 0.0012 18.7 0.1 2.3 2 1 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EKE42730.1 - 5.2e-05 22.7 0.0 8.1e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EKE42730.1 - 0.0037 16.7 0.0 0.0045 16.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Septin PF00735.18 EKE42730.1 - 0.0058 16.0 0.1 0.011 15.0 0.0 1.4 2 0 0 2 2 2 1 Septin AAA_16 PF13191.6 EKE42730.1 - 0.012 16.1 0.0 0.015 15.7 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 EKE42730.1 - 0.025 13.8 0.0 0.025 13.7 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_22 PF13401.6 EKE42730.1 - 0.03 14.6 0.0 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EKE42730.1 - 0.039 13.9 0.0 0.052 13.5 0.0 1.2 1 0 0 1 1 1 0 NTPase AAA_7 PF12775.7 EKE42730.1 - 0.047 13.2 0.1 0.073 12.6 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EKE42730.1 - 0.048 13.4 0.0 0.073 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EKE42730.1 - 0.053 13.4 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain DAP3 PF10236.9 EKE42730.1 - 0.059 12.5 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 PduV-EutP PF10662.9 EKE42730.1 - 0.069 12.9 0.4 0.13 12.0 0.4 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MCM PF00493.23 EKE42730.1 - 0.073 12.2 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain ATPase_2 PF01637.18 EKE42730.1 - 0.083 12.8 0.1 0.11 12.4 0.1 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea cobW PF02492.19 EKE42730.1 - 0.095 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EKE42730.1 - 0.11 13.0 0.2 0.17 12.4 0.1 1.4 1 1 0 1 1 1 0 ABC transporter Pox_A32 PF04665.12 EKE42730.1 - 0.12 11.9 0.1 0.22 11.0 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein TniB PF05621.11 EKE42730.1 - 0.16 11.4 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein NB-ARC PF00931.22 EKE42730.1 - 0.17 11.0 0.1 0.24 10.5 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain dNK PF01712.19 EKE42731.1 - 1.2e-10 41.5 5.5 5.1e-06 26.5 0.8 2.1 1 1 1 2 2 2 2 Deoxynucleoside kinase ASFV_J13L PF05568.11 EKE42734.1 - 0.001 18.8 0.3 0.0016 18.2 0.3 1.2 1 0 0 1 1 1 1 African swine fever virus J13L protein Orf78 PF06024.12 EKE42734.1 - 0.0019 18.5 0.2 0.0033 17.7 0.2 1.4 1 0 0 1 1 1 1 Orf78 (ac78) Nodulin-like PF06813.13 EKE42734.1 - 0.0022 17.5 0.0 0.0033 17.0 0.0 1.1 1 0 0 1 1 1 1 Nodulin-like MFS_2 PF13347.6 EKE42734.1 - 0.0034 16.0 0.0 0.0044 15.6 0.0 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_Mycoplasma PF07672.13 EKE42734.1 - 0.0077 15.6 1.2 0.0082 15.5 0.3 1.4 2 0 0 2 2 2 1 Mycoplasma MFS transporter DUF4083 PF13314.6 EKE42734.1 - 0.014 15.3 1.2 0.025 14.5 1.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Sigma_reg_N PF13800.6 EKE42734.1 - 0.02 15.2 1.3 0.041 14.2 1.3 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF3139 PF11337.8 EKE42734.1 - 0.027 15.1 1.2 0.027 15.1 1.2 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF3139) TMEM154 PF15102.6 EKE42734.1 - 0.028 14.3 0.1 0.051 13.5 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF5385 PF17359.2 EKE42734.1 - 0.035 13.7 0.6 0.061 12.9 0.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5385) ECSCR PF15820.5 EKE42734.1 - 0.036 13.9 0.1 0.11 12.4 0.1 1.8 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Peptidase_M56 PF05569.11 EKE42734.1 - 0.055 12.7 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF3377 PF11857.8 EKE42734.1 - 0.061 13.3 0.2 0.13 12.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) EphA2_TM PF14575.6 EKE42734.1 - 0.077 13.9 0.1 0.16 12.9 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 EKE42734.1 - 0.086 13.8 0.2 0.17 12.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CD34_antigen PF06365.12 EKE42734.1 - 0.58 9.7 6.9 0.39 10.3 0.5 2.3 1 1 1 2 2 2 0 CD34/Podocalyxin family TLD PF07534.16 EKE42735.1 - 0.0007 19.8 0.6 0.0027 17.9 0.6 2.1 1 0 0 1 1 1 1 TLD CHASE3 PF05227.13 EKE42735.1 - 0.072 13.0 7.5 0.47 10.4 2.3 2.6 2 1 0 2 2 2 0 CHASE3 domain Fib_alpha PF08702.10 EKE42735.1 - 0.17 12.1 35.3 1.1 9.4 10.9 3.6 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.19 EKE42735.1 - 0.22 9.4 14.1 0.13 10.2 2.9 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 EKE42735.1 - 1.2 8.9 24.5 0.27 11.0 5.3 4.6 3 2 1 4 4 4 0 Septum formation initiator DUF4407 PF14362.6 EKE42735.1 - 4 6.7 11.2 0.98 8.7 6.5 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 EKE42735.1 - 4.3 7.8 35.4 2.6 8.5 3.2 6.2 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) Fez1 PF06818.15 EKE42735.1 - 6.4 7.2 23.5 9 6.7 12.4 2.4 1 1 0 2 2 2 0 Fez1 NHL PF01436.21 EKE42736.1 - 4.3e-11 42.3 2.8 0.017 15.1 0.0 5.0 5 0 0 5 5 5 3 NHL repeat zf-B_box PF00643.24 EKE42736.1 - 0.00022 21.3 6.0 0.00022 21.3 6.0 4.7 4 1 1 5 5 5 1 B-box zinc finger zf-RING_UBOX PF13445.6 EKE42736.1 - 0.0014 18.6 6.8 0.0014 18.6 6.8 2.5 2 0 0 2 2 2 1 RING-type zinc-finger SGL PF08450.12 EKE42736.1 - 0.12 11.9 0.0 4.9 6.7 0.0 2.5 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Prok-RING_4 PF14447.6 EKE42736.1 - 3.1 7.8 18.5 0.077 12.9 6.3 3.3 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 Rrn6 PF10214.9 EKE42737.1 - 0.015 13.9 13.1 0.021 13.3 13.1 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF4064 PF13273.6 EKE42737.1 - 0.023 15.0 0.1 0.05 13.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) LAP1C PF05609.12 EKE42737.1 - 0.043 12.9 14.5 0.094 11.8 14.5 1.5 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Phospholamban PF04272.14 EKE42737.1 - 1.5 8.3 4.5 3.6 7.1 4.5 1.6 1 0 0 1 1 1 0 Phospholamban Ponericin PF07442.11 EKE42738.1 - 0.011 15.8 4.2 0.027 14.5 4.2 1.7 1 0 0 1 1 1 0 Ponericin PET PF06297.14 EKE42738.1 - 1.3 9.4 4.9 10 6.5 3.5 2.3 1 1 1 2 2 2 0 PET Domain DUF4446 PF14584.6 EKE42738.1 - 4.1 7.4 7.8 4 7.4 5.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) RasGEF PF00617.19 EKE42739.1 - 8.8e-08 32.5 9.1 8.8e-08 32.5 9.1 2.2 2 1 1 3 3 3 1 RasGEF domain DUF3510 PF12022.8 EKE42739.1 - 0.06 13.7 0.0 0.28 11.6 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) GAT PF03127.14 EKE42739.1 - 0.078 13.3 1.7 0.43 10.9 1.7 2.3 1 0 0 1 1 1 0 GAT domain UBA_4 PF14555.6 EKE42742.1 - 0.00022 20.9 0.0 0.00048 19.9 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain API5 PF05918.11 EKE42742.1 - 0.0029 16.5 1.3 0.0072 15.2 1.2 1.8 1 1 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) KAR PF15222.6 EKE42742.1 - 0.021 15.1 1.1 0.47 10.8 0.1 2.4 2 0 0 2 2 2 0 Kidney androgen-regulated Cullin_binding PF03556.15 EKE42742.1 - 0.026 15.0 0.3 0.026 15.0 0.3 2.0 2 1 0 2 2 2 0 Cullin binding Tnp_22_trimer PF17489.2 EKE42742.1 - 0.52 10.3 3.9 0.31 11.0 1.1 2.2 2 0 0 2 2 2 0 L1 transposable element trimerization domain DUF2856 PF11043.8 EKE42743.1 - 0.36 11.0 3.8 0.27 11.4 0.3 2.5 2 2 0 2 2 2 0 Protein of unknown function (DUF2856) SCO1-SenC PF02630.14 EKE42743.1 - 0.83 9.6 3.3 5.1 7.0 0.3 2.4 2 0 0 2 2 2 0 SCO1/SenC LRR_5 PF13306.6 EKE42744.1 - 3.6e-65 217.7 63.9 1e-21 77.2 7.2 5.9 4 2 2 6 6 6 5 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 EKE42744.1 - 2.1e-12 46.6 2.6 0.041 13.6 0.0 8.9 6 3 3 10 10 10 3 Leucine rich repeat LRR_4 PF12799.7 EKE42744.1 - 0.00063 20.1 25.2 0.67 10.5 0.1 9.8 10 2 2 13 13 13 2 Leucine Rich repeats (2 copies) DUF1699 PF08004.11 EKE42744.1 - 0.044 13.5 0.8 0.54 9.9 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1699) PWI PF01480.17 EKE42746.1 - 5.6e-21 74.6 0.6 8.5e-21 74.1 0.6 1.3 1 0 0 1 1 1 1 PWI domain Ras PF00071.22 EKE42747.1 - 5.2e-52 175.7 0.0 6.4e-52 175.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42747.1 - 1.7e-23 83.1 0.0 2.4e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EKE42747.1 - 5.8e-07 29.1 0.0 6.4e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EKE42747.1 - 0.06 12.7 0.0 0.17 11.2 0.0 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region RNB PF00773.19 EKE42748.1 - 3.4e-08 33.2 3.7 0.00016 21.1 1.7 3.5 1 1 0 2 2 2 2 RNB domain TLD PF07534.16 EKE42749.1 - 7.5e-08 32.7 28.7 0.0021 18.3 1.0 6.1 5 0 0 5 5 5 4 TLD UPF0029 PF01205.19 EKE42751.1 - 5.9e-32 110.1 0.1 1.7e-31 108.6 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EKE42751.1 - 2.3e-09 37.6 2.9 2.3e-09 37.6 2.9 2.3 1 1 1 2 2 2 1 RWD domain VIT1 PF01988.19 EKE42752.1 - 0.082 12.8 1.7 0.091 12.6 1.7 1.1 1 0 0 1 1 1 0 VIT family MOZART1 PF12554.8 EKE42752.1 - 0.11 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated U79_P34 PF03064.16 EKE42752.1 - 0.57 9.5 14.4 0.89 8.9 14.4 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 MAS20 PF02064.15 EKE42752.1 - 4.9 7.2 9.3 7 6.8 9.3 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor FNIP PF05725.12 EKE42753.1 - 0.051 13.7 3.6 0.86 9.8 0.1 3.9 3 1 0 3 3 3 0 FNIP Repeat Cwf_Cwc_15 PF04889.12 EKE42754.1 - 1.2e-24 87.4 20.1 9.5e-18 64.8 13.9 2.1 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein RNA_pol_3_Rpc31 PF11705.8 EKE42754.1 - 0.14 12.4 17.3 0.2 11.9 17.3 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 GBR_NSP5 PF17580.2 EKE42754.1 - 0.34 10.7 10.9 0.49 10.2 10.2 1.6 1 1 1 2 2 2 0 Group B Rotavirus Non-structural protein 5 CemA PF03040.14 EKE42754.1 - 2.1 8.3 7.6 2.5 8.0 7.6 1.2 1 0 0 1 1 1 0 CemA family Zip PF02535.22 EKE42754.1 - 3.6 6.7 7.7 4.1 6.5 7.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 EKE42754.1 - 7 6.6 7.6 8 6.4 7.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Myb_DNA-binding PF00249.31 EKE42755.1 - 0.00013 22.1 0.0 0.0058 16.8 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain OpgC_C PF10129.9 EKE42756.1 - 0.0022 16.9 0.1 0.0024 16.8 0.1 1.0 1 0 0 1 1 1 1 OpgC protein VMA21 PF09446.10 EKE42756.1 - 0.011 15.9 4.6 0.013 15.5 4.6 1.2 1 0 0 1 1 1 0 VMA21-like domain PCI PF01399.27 EKE42757.1 - 2.6e-07 31.1 2.8 4.1e-07 30.5 0.6 2.4 2 0 0 2 2 2 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 EKE42757.1 - 0.0074 16.3 1.7 0.03 14.3 0.1 2.5 3 0 0 3 3 3 1 CSN8/PSMD8/EIF3K family Vma12 PF11712.8 EKE42757.1 - 0.1 12.7 0.1 0.33 11.0 0.1 1.8 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase F_actin_bund_C PF18060.1 EKE42758.1 - 2.4e-27 94.9 22.0 2.4e-27 94.9 22.0 2.8 2 1 1 3 3 3 1 F actin bundling C terminal PAPS_reduct PF01507.19 EKE42758.1 - 0.015 15.4 0.4 0.015 15.4 0.4 2.2 1 1 1 2 2 2 0 Phosphoadenosine phosphosulfate reductase family Macoilin PF09726.9 EKE42758.1 - 0.51 8.8 14.1 0.63 8.5 14.1 1.3 1 0 0 1 1 1 0 Macoilin family P2_N PF18628.1 EKE42759.1 - 2.5 7.8 6.0 3.7 7.3 0.2 3.6 3 1 1 4 4 4 0 Viral coat protein P2 N-terminal domain DUF1985 PF09331.11 EKE42760.1 - 0.053 13.5 1.7 0.067 13.2 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1985) CHASE9 PF17153.4 EKE42763.1 - 0.046 13.9 0.1 0.085 13.0 0.1 1.4 1 0 0 1 1 1 0 Periplasmic sensor domain, extracellular DUF16 PF01519.16 EKE42764.1 - 0.004 17.6 24.1 0.0063 17.0 1.5 2.8 1 1 2 3 3 3 2 Protein of unknown function DUF16 GIT_CC PF16559.5 EKE42764.1 - 0.027 14.3 0.1 0.027 14.3 0.1 3.4 5 0 0 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor Bul1_C PF04426.12 EKE42764.1 - 0.081 12.3 12.6 0.17 11.2 7.4 2.1 1 1 1 2 2 2 0 Bul1 C terminus DUF2201 PF09967.9 EKE42764.1 - 0.27 11.4 2.7 7 6.8 0.0 2.7 2 1 1 3 3 3 0 VWA-like domain (DUF2201) Mto2_bdg PF12808.7 EKE42764.1 - 1.2 9.5 9.4 7.5 6.9 0.3 3.3 2 2 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF4693 PF15764.5 EKE42764.1 - 1.5 8.3 12.2 1.3 8.5 0.3 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4693) WD40_alt PF14077.6 EKE42764.1 - 1.8 8.5 5.4 0.93 9.4 0.5 2.9 3 0 0 3 3 3 0 Alternative WD40 repeat motif DUF3573 PF12097.8 EKE42764.1 - 2.2 7.0 8.6 2.6 6.8 5.8 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF3573) DUF4795 PF16043.5 EKE42764.1 - 4 7.0 24.2 1e+02 2.4 24.2 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF2304 PF10066.9 EKE42764.1 - 7.3 6.9 5.3 16 5.7 0.9 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) DUF4407 PF14362.6 EKE42764.1 - 8 5.7 18.9 34 3.7 18.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Metallophos PF00149.28 EKE42765.1 - 2.5e-31 109.8 1.5 3.3e-31 109.4 1.5 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EKE42765.1 - 6.8e-05 23.2 0.3 0.00013 22.3 0.3 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Corona_NS3b PF03053.14 EKE42765.1 - 0.035 13.9 0.2 0.073 12.8 0.2 1.5 1 0 0 1 1 1 0 ORF3b coronavirus protein Strumpellin PF10266.9 EKE42768.1 - 0 1117.9 29.1 0 1115.7 29.1 1.8 1 1 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin DUF2672 PF10878.8 EKE42768.1 - 0.038 13.9 1.0 0.28 11.2 1.0 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2672) Csm1_B PF18211.1 EKE42768.1 - 0.16 11.8 1.2 0.65 9.9 1.2 2.1 1 0 0 1 1 1 0 Csm1 subunit domain B DUF2990 PF11693.8 EKE42768.1 - 0.51 10.5 2.0 1 9.6 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2990) FAS_N PF17828.1 EKE42768.1 - 0.58 10.2 4.6 2 8.4 0.0 3.2 3 0 0 3 3 3 0 N-terminal domain in fatty acid synthase subunit beta DEAD PF00270.29 EKE42769.1 - 3.3e-20 72.6 1.7 5e-20 72.0 0.2 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE42769.1 - 5.8e-13 49.2 6.9 2.8e-11 43.7 2.3 4.3 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE42769.1 - 4.4e-11 43.1 1.8 4.4e-11 43.1 1.8 3.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF4332 PF14229.6 EKE42769.1 - 0.026 14.8 0.0 0.093 13.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4332) AAA PF00004.29 EKE42769.1 - 0.072 13.5 8.6 0.027 14.9 4.1 2.6 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EKE42769.1 - 0.14 12.5 0.5 6.9 7.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain DUF2857 PF11198.8 EKE42769.1 - 0.46 10.3 4.4 1 9.1 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2857) DUF3243 PF11588.8 EKE42770.1 - 0.033 14.5 7.7 0.93 9.8 0.1 3.9 3 3 1 4 4 4 0 Protein of unknown function (DUF3243) LMBR1 PF04791.16 EKE42771.1 - 1.3e-85 288.3 32.0 1.5e-85 288.0 32.0 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein PI3K_P85_iSH2 PF16454.5 EKE42771.1 - 0.12 12.0 2.7 0.21 11.2 2.7 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF5638 PF18688.1 EKE42771.1 - 3.8 7.9 9.7 1.1 9.5 1.9 2.8 1 1 2 3 3 3 0 Family of unknown function (DUF5638) PIG-X PF08320.12 EKE42772.1 - 6.1e-25 88.4 0.9 8.5e-25 87.9 0.0 1.6 2 0 0 2 2 2 1 PIG-X / PBN1 SSFA2_C PF14723.6 EKE42772.1 - 0.017 15.0 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Sperm-specific antigen 2 C-terminus WD40 PF00400.32 EKE42773.1 - 1.7e-53 177.4 38.9 3.7e-11 43.4 0.5 8.8 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE42773.1 - 2.3e-16 59.9 3.4 0.019 15.3 0.0 6.6 2 2 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 EKE42773.1 - 2.7e-09 37.4 0.4 4.4e-09 36.7 0.4 1.3 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 EKE42773.1 - 1.7e-05 24.0 0.5 3.1 6.7 0.1 4.4 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EKE42773.1 - 3.3e-05 22.8 2.5 0.93 8.0 0.0 4.0 3 1 1 4 4 4 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EKE42773.1 - 0.024 13.4 0.3 0.11 11.2 0.1 2.1 2 1 0 2 2 2 0 Nup133 N terminal like PD40 PF07676.12 EKE42773.1 - 3.3 7.7 4.8 39 4.4 0.0 4.6 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat PND PF17949.1 EKE42775.1 - 0.0029 17.8 1.2 0.0035 17.6 0.3 1.7 2 0 0 2 2 2 1 FANCM pseudonuclease domain YkyB PF14177.6 EKE42776.1 - 0.14 12.5 1.5 3.8 7.8 0.2 2.3 1 1 1 2 2 2 0 YkyB-like protein UCH PF00443.29 EKE42778.1 - 3.9e-12 46.2 12.6 1.9e-11 44.0 12.6 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Corona_M PF01635.18 EKE42778.1 - 0.025 13.9 1.0 0.23 10.8 0.1 2.1 2 0 0 2 2 2 0 Coronavirus M matrix/glycoprotein MAGE PF01454.19 EKE42779.1 - 5e-22 78.7 1.2 8.3e-21 74.7 1.2 2.2 1 1 0 1 1 1 1 MAGE family Mga PF05043.13 EKE42779.1 - 0.12 13.0 1.2 0.38 11.4 0.1 2.2 2 0 0 2 2 2 0 Mga helix-turn-helix domain PAP2 PF01569.21 EKE42780.1 - 7e-18 64.7 6.2 7e-18 64.7 6.2 2.5 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EKE42780.1 - 3.3e-05 23.7 7.6 3.3e-05 23.7 7.6 2.7 2 1 0 3 3 3 1 PAP2 superfamily K1 PF02960.14 EKE42780.1 - 0.17 12.0 12.3 5 7.3 0.3 3.5 3 0 0 3 3 3 0 K1 glycoprotein DUF4131 PF13567.6 EKE42780.1 - 2.8 7.5 4.8 4 7.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) NT-C2 PF10358.9 EKE42781.1 - 8.3e-20 71.0 0.1 8.3e-20 71.0 0.1 3.5 3 1 0 3 3 3 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 EKE42781.1 - 1.9e-11 44.2 0.0 6.4e-11 42.5 0.0 2.0 1 0 0 1 1 1 1 DIL domain TolA_bind_tri PF16331.5 EKE42781.1 - 0.0019 18.2 8.1 0.0019 18.2 8.1 6.4 4 2 2 7 7 7 1 TolA binding protein trimerisation Ax_dynein_light PF10211.9 EKE42781.1 - 0.01 15.8 22.6 0.01 15.8 22.6 6.3 1 1 3 5 5 5 0 Axonemal dynein light chain PP2C_2 PF13672.6 EKE42782.1 - 5.2e-12 45.9 0.0 9.1e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE42782.1 - 1.7e-05 24.9 0.0 2.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Ribonuclease_T2 PF00445.18 EKE42783.1 - 7.6e-31 107.7 5.0 9.3e-31 107.5 5.0 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family tRNA-synt_1e PF01406.19 EKE42784.1 - 2.8e-116 388.1 1.4 6.4e-116 386.9 1.4 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EKE42784.1 - 2.5e-09 36.4 0.9 0.0001 21.2 0.1 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 EKE42784.1 - 0.00018 21.9 0.1 0.0013 19.2 0.0 2.4 2 0 0 2 2 2 1 DALR domain tRNA-synt_1 PF00133.22 EKE42784.1 - 0.0021 16.4 0.4 0.01 14.1 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Mannitol_dh PF01232.23 EKE42784.1 - 0.079 13.1 0.4 0.47 10.6 0.0 2.3 2 0 0 2 2 2 0 Mannitol dehydrogenase Rossmann domain DUF4618 PF15397.6 EKE42784.1 - 1.1 8.6 13.8 0.41 10.0 1.6 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) DUF5348 PF17295.2 EKE42785.1 - 0.083 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5348) WD40 PF00400.32 EKE42786.1 - 1.3e-14 54.3 0.1 2.8e-05 24.8 0.0 6.2 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE42786.1 - 2e-07 31.2 1.4 0.57 10.5 0.0 4.4 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EKE42786.1 - 0.0035 17.2 1.0 0.067 13.1 0.2 3.0 3 0 0 3 3 3 1 PQQ enzyme repeat PQQ_3 PF13570.6 EKE42786.1 - 0.0038 17.7 0.0 33 5.1 0.0 3.6 3 0 0 3 3 3 1 PQQ-like domain RRM_1 PF00076.22 EKE42787.1 - 4.8e-40 135.2 5.1 7.5e-23 80.1 0.5 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EKE42787.1 - 0.00039 20.4 0.2 0.00092 19.2 0.2 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 EKE42787.1 - 0.00042 19.9 0.2 0.38 10.5 0.1 2.9 2 0 0 2 2 2 2 Ribonuclease B OB domain RRM_occluded PF16842.5 EKE42787.1 - 0.0013 18.6 0.1 0.038 13.9 0.0 2.4 2 1 0 2 2 2 1 Occluded RNA-recognition motif RRM_9 PF18444.1 EKE42787.1 - 0.0053 16.6 0.3 0.016 15.0 0.0 1.9 2 1 0 2 2 2 1 RNA recognition motif RRM_7 PF16367.5 EKE42787.1 - 0.0066 16.5 0.2 1.2 9.3 0.0 2.9 2 2 0 2 2 2 1 RNA recognition motif Calcipressin PF04847.12 EKE42787.1 - 0.019 14.7 0.8 0.17 11.6 0.1 2.2 2 0 0 2 2 2 0 Calcipressin Nup35_RRM PF05172.13 EKE42787.1 - 0.16 11.9 1.1 0.8 9.7 0.0 2.5 2 2 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Cep3 PF16846.5 EKE42788.1 - 0.0014 17.2 0.2 0.0017 16.9 0.2 1.2 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B Importin_rep_4 PF18808.1 EKE42789.1 - 2.6e-05 24.4 3.2 7.5e-05 22.9 0.3 3.2 3 0 0 3 3 3 1 Importin repeat HEAT_2 PF13646.6 EKE42789.1 - 0.0026 18.1 0.0 7.7 7.0 0.0 3.4 3 1 0 3 3 3 2 HEAT repeats HEAT PF02985.22 EKE42789.1 - 0.022 15.0 1.6 20 5.8 0.0 4.9 3 0 0 3 3 3 0 HEAT repeat Arm PF00514.23 EKE42789.1 - 0.035 14.1 3.4 0.29 11.3 0.0 3.7 3 1 1 4 4 4 0 Armadillo/beta-catenin-like repeat ParcG PF10274.9 EKE42789.1 - 0.42 10.7 12.5 4.5 7.4 0.2 4.8 5 1 0 5 5 5 0 Parkin co-regulated protein DUF1981 PF09324.10 EKE42789.1 - 1.3 8.9 7.2 1.6 8.7 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF1981) DUF727 PF05303.12 EKE42789.1 - 2.9 8.0 5.9 0.42 10.7 0.1 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF727) Prefoldin PF02996.17 EKE42791.1 - 1.2e-20 73.6 6.7 2.4e-20 72.6 4.8 1.9 1 1 1 2 2 2 1 Prefoldin subunit Prefoldin_2 PF01920.20 EKE42791.1 - 0.00028 20.8 0.8 0.00028 20.8 0.8 2.9 2 1 0 2 2 2 1 Prefoldin subunit Tektin PF03148.14 EKE42791.1 - 0.004 16.0 1.9 0.004 16.0 1.9 2.0 2 1 0 2 2 2 1 Tektin family CENP-F_leu_zip PF10473.9 EKE42791.1 - 0.014 15.4 8.4 0.32 11.0 2.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 EKE42791.1 - 0.046 13.5 1.4 0.15 11.8 0.2 2.2 2 0 0 2 2 2 0 Septum formation initiator DUF1664 PF07889.12 EKE42791.1 - 0.09 12.8 9.5 0.8 9.8 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FliP PF00813.20 EKE42791.1 - 0.12 12.2 0.8 0.18 11.6 0.2 1.5 1 1 1 2 2 2 0 FliP family Noelin-1 PF12308.8 EKE42791.1 - 0.23 11.4 2.2 1 9.4 0.1 2.1 2 0 0 2 2 2 0 Neurogenesis glycoprotein DUF3450 PF11932.8 EKE42791.1 - 0.3 10.4 5.7 1.4 8.2 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) CLZ PF16526.5 EKE42791.1 - 0.33 11.3 6.1 2.2 8.7 0.4 2.3 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels XhlA PF10779.9 EKE42791.1 - 2.7 8.3 8.5 6.2 7.1 5.2 2.3 2 0 0 2 2 2 0 Haemolysin XhlA FlxA PF14282.6 EKE42791.1 - 3 7.9 7.9 3.8 7.6 1.7 2.3 2 0 0 2 2 2 0 FlxA-like protein DUF4200 PF13863.6 EKE42791.1 - 3.3 8.1 11.6 1.1 9.6 3.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) RhoGEF PF00621.20 EKE42792.1 - 7e-30 104.6 3.9 7e-30 104.6 3.9 3.4 3 1 0 3 3 3 1 RhoGEF domain IQ PF00612.27 EKE42792.1 - 0.0068 16.1 0.0 0.018 14.8 0.0 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif RAC_head PF16717.5 EKE42793.1 - 0.053 14.5 6.9 0.34 11.9 0.5 3.0 3 0 0 3 3 3 0 Ribosome-associated complex head domain Peptidase_C48 PF02902.19 EKE42793.1 - 0.053 13.3 0.1 0.053 13.3 0.1 2.1 3 0 0 3 3 3 0 Ulp1 protease family, C-terminal catalytic domain CLN3 PF02487.17 EKE42796.1 - 5.1e-58 197.0 17.0 5.9e-58 196.8 17.0 1.0 1 0 0 1 1 1 1 CLN3 protein MFS_1 PF07690.16 EKE42796.1 - 0.00039 19.4 30.8 0.00052 19.1 5.1 3.1 1 1 2 3 3 3 2 Major Facilitator Superfamily Myb_DNA-binding PF00249.31 EKE42797.1 - 3.8e-10 39.8 0.1 8.2e-10 38.7 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 EKE42797.1 - 3.7e-09 36.2 6.3 7.3e-09 35.3 6.3 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 EKE42797.1 - 0.015 15.5 0.1 0.045 14.0 0.1 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain OSR1_C PF12202.8 EKE42797.1 - 0.12 12.6 1.0 0.32 11.3 1.0 1.7 1 0 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain Tnp_zf-ribbon_2 PF13842.6 EKE42797.1 - 2.4 9.0 9.5 36 5.3 9.5 2.6 1 1 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon DHHC PF01529.20 EKE42799.1 - 5.3e-22 78.4 12.0 5.3e-22 78.4 12.0 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase AhpC-TSA PF00578.21 EKE42800.1 - 1.8e-27 95.7 0.0 2.2e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EKE42800.1 - 1e-10 41.5 0.0 1.3e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin DENN PF02141.21 EKE42801.1 - 6.8e-19 68.5 1.6 1.9e-17 63.8 1.6 2.6 1 1 0 1 1 1 1 DENN (AEX-3) domain C2 PF00168.30 EKE42801.1 - 6.5e-13 48.9 0.1 1.8e-12 47.5 0.1 1.8 1 0 0 1 1 1 1 C2 domain SBF2 PF12335.8 EKE42801.1 - 1.1e-06 28.4 1.2 2.3e-06 27.4 1.2 1.4 1 0 0 1 1 1 1 Myotubularin protein Presenilin PF01080.17 EKE42802.1 - 0.8 8.4 5.3 0.87 8.3 5.3 1.0 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 EKE42802.1 - 2.1 6.5 9.3 2.1 6.5 9.3 1.1 1 0 0 1 1 1 0 CDC45-like protein zf-CCCH PF00642.24 EKE42803.1 - 8.1e-09 35.2 13.6 1.7e-05 24.6 3.4 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EKE42803.1 - 0.00016 21.8 3.8 0.069 13.4 0.6 2.3 2 0 0 2 2 2 2 Zinc-finger containing family Torus PF16131.5 EKE42803.1 - 0.00067 20.3 8.7 0.092 13.4 0.1 3.3 2 1 0 2 2 2 1 Torus domain zf_CCCH_4 PF18345.1 EKE42803.1 - 0.012 15.6 1.8 0.012 15.6 1.8 3.1 2 1 0 2 2 2 0 Zinc finger domain RRM_1 PF00076.22 EKE42803.1 - 0.037 13.9 0.1 0.18 11.6 0.0 2.0 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MRP-63 PF14978.6 EKE42803.1 - 0.049 14.3 0.7 0.13 12.9 0.5 1.9 1 1 0 1 1 1 0 Mitochondrial ribosome protein 63 Myb_DNA-binding PF00249.31 EKE42804.1 - 0.072 13.3 0.4 0.15 12.2 0.4 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain TIR_3 PF18567.1 EKE42804.1 - 0.11 12.5 0.5 6.5 6.8 0.3 2.6 2 1 0 2 2 2 0 Toll/interleukin-1 receptor domain SNF2_N PF00176.23 EKE42805.1 - 0.11 11.2 0.2 0.94 8.1 0.0 2.0 2 0 0 2 2 2 0 SNF2 family N-terminal domain TLD PF07534.16 EKE42806.1 - 6.8e-27 94.4 0.3 1.4e-26 93.4 0.3 1.5 1 0 0 1 1 1 1 TLD BSD PF03909.17 EKE42806.1 - 0.00025 21.0 0.2 0.00087 19.3 0.2 1.9 1 0 0 1 1 1 1 BSD domain UBX PF00789.20 EKE42807.1 - 2.5e-05 24.4 0.1 7.1e-05 22.9 0.1 1.8 1 0 0 1 1 1 1 UBX domain DUF883 PF05957.13 EKE42808.1 - 0.026 15.1 18.1 0.082 13.5 1.4 5.3 1 1 7 8 8 8 0 Bacterial protein of unknown function (DUF883) HALZ PF02183.18 EKE42808.1 - 9.5 6.5 9.3 14 6.0 0.4 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper AMP-binding PF00501.28 EKE42809.1 - 5.7e-86 288.8 0.0 9.4e-86 288.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme RhoGAP PF00620.27 EKE42810.1 - 8e-32 110.2 0.2 5.5e-31 107.5 0.0 2.3 2 1 0 2 2 2 1 RhoGAP domain PH PF00169.29 EKE42810.1 - 4.9e-05 23.8 0.1 0.00013 22.4 0.1 1.7 1 0 0 1 1 1 1 PH domain SlyX PF04102.12 EKE42810.1 - 0.044 14.4 3.4 0.67 10.6 0.8 3.1 3 0 0 3 3 3 0 SlyX PhoU PF01895.19 EKE42810.1 - 0.077 13.5 0.8 0.077 13.5 0.8 2.3 3 0 0 3 3 3 0 PhoU domain DSPc PF00782.20 EKE42811.1 - 3.3e-27 94.9 0.0 8.2e-27 93.6 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 EKE42811.1 - 2e-19 69.1 32.9 1.1e-08 34.7 5.4 3.0 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EKE42811.1 - 1.2e-17 63.7 45.9 5e-07 29.9 4.3 4.1 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EKE42811.1 - 3.2e-06 26.8 16.6 2.4e-05 23.9 6.2 2.0 1 1 1 2 2 2 2 Leucine-rich repeat Y_phosphatase PF00102.27 EKE42811.1 - 0.00018 21.2 0.0 0.0069 16.0 0.0 2.3 2 0 0 2 2 2 1 Protein-tyrosine phosphatase LRR_1 PF00560.33 EKE42811.1 - 0.00065 19.9 11.8 1.2 10.0 0.2 5.6 4 1 0 4 4 4 1 Leucine Rich Repeat LRR_5 PF13306.6 EKE42811.1 - 0.0034 17.4 15.7 0.027 14.4 5.1 2.8 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) SWIB PF02201.18 EKE42811.1 - 0.0096 15.8 0.1 0.029 14.2 0.1 1.8 1 0 0 1 1 1 1 SWIB/MDM2 domain PTPlike_phytase PF14566.6 EKE42811.1 - 0.036 14.2 0.0 0.084 13.0 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate LRR_6 PF13516.6 EKE42811.1 - 0.34 11.1 15.9 6.6 7.1 0.4 5.0 5 0 0 5 5 5 0 Leucine Rich repeat AAA_12 PF13087.6 EKE42812.1 - 1.5e-39 135.7 2.8 2.1e-39 135.2 0.8 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EKE42812.1 - 1.7e-25 90.3 9.0 7.6e-14 52.1 0.1 3.2 2 1 1 3 3 3 2 AAA domain DUF2439 PF10382.9 EKE42812.1 - 3e-10 40.3 0.6 3e-10 40.3 0.6 3.4 4 0 0 4 4 4 1 Protein of unknown function (DUF2439) Viral_helicase1 PF01443.18 EKE42812.1 - 1.6e-09 37.9 2.7 0.026 14.3 0.0 3.8 4 0 0 4 4 4 3 Viral (Superfamily 1) RNA helicase PIF1 PF05970.14 EKE42812.1 - 1.7e-08 34.0 1.2 6.2e-08 32.2 0.0 2.4 3 0 0 3 3 3 1 PIF1-like helicase AAA_30 PF13604.6 EKE42812.1 - 4.4e-08 33.1 0.0 4.1e-07 29.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain zf-GRF PF06839.12 EKE42812.1 - 1.8e-06 27.9 3.7 4.5e-06 26.7 3.7 1.7 1 0 0 1 1 1 1 GRF zinc finger ResIII PF04851.15 EKE42812.1 - 1.7e-05 24.9 0.0 1.7e-05 24.9 0.0 3.4 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit AAA_16 PF13191.6 EKE42812.1 - 0.0027 18.1 0.0 0.006 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain UvrD_C_2 PF13538.6 EKE42812.1 - 0.022 14.6 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.14 EKE42812.1 - 0.04 13.8 0.0 0.2 11.5 0.0 2.3 1 1 0 1 1 1 0 Helicase RabGAP-TBC PF00566.18 EKE42813.1 - 1.4e-31 109.8 3.5 3.8e-31 108.4 3.5 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF2701 PF10857.8 EKE42813.1 - 0.1 12.6 1.6 3.3 7.8 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2701) Nop52 PF05997.12 EKE42815.1 - 8.4e-37 127.1 5.5 8.4e-37 127.1 5.5 1.4 2 0 0 2 2 2 1 Nucleolar protein,Nop52 NAPRTase_C PF17956.1 EKE42815.1 - 0.017 15.5 2.0 0.3 11.5 0.0 2.8 3 0 0 3 3 3 0 Nicotinate phosphoribosyltransferase C-terminal domain DUF4951 PF16309.5 EKE42815.1 - 0.029 14.4 0.0 0.11 12.6 0.0 2.0 1 0 0 1 1 1 0 Domian of unknown function (DUF4951) REC1 PF18501.1 EKE42815.1 - 7.4 6.4 18.1 0.52 10.2 8.4 2.6 2 1 1 3 3 3 0 Alpha helical recognition lobe domain BUD22 PF09073.10 EKE42816.1 - 2.4 7.4 41.4 3.2 7.0 41.4 1.1 1 0 0 1 1 1 0 BUD22 Ribosomal_S13 PF00416.22 EKE42816.1 - 3.7 8.0 21.8 0.73 10.2 1.8 3.0 1 1 2 3 3 3 0 Ribosomal protein S13/S18 GM_CSF PF01109.17 EKE42816.1 - 6.6 6.9 8.1 0.27 11.4 0.8 2.4 2 1 0 3 3 3 0 Granulocyte-macrophage colony-stimulating factor DUF848 PF05852.11 EKE42816.1 - 8.2 6.5 24.2 8 6.6 19.7 2.6 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) CDP-OH_P_transf PF01066.21 EKE42817.1 - 1.2e-07 32.4 0.3 1.2e-07 32.4 0.3 3.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Phage_holin_3_3 PF16083.5 EKE42817.1 - 3.6 7.8 8.8 7.3 6.8 0.0 2.9 3 0 0 3 3 3 0 LydA holin phage, holin superfamily III RRM_1 PF00076.22 EKE42818.1 - 0.0011 18.7 0.0 0.0037 17.1 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 EKE42818.1 - 0.0038 17.9 0.1 0.0038 17.9 0.1 4.0 3 1 1 5 5 5 1 Torus domain DUF4748 PF15932.5 EKE42818.1 - 1.2 8.9 5.1 5.5 6.8 5.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Rad51 PF08423.11 EKE42819.1 - 1.4e-119 398.1 0.2 1.7e-119 397.8 0.2 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EKE42819.1 - 2.1e-13 50.3 0.6 2.9e-13 49.9 0.6 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EKE42819.1 - 2.2e-10 40.4 0.0 3.6e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EKE42819.1 - 2e-09 37.1 1.7 2.2e-09 37.0 0.4 1.7 2 0 0 2 2 2 1 KaiC RNA_pol_A_CTD PF03118.15 EKE42819.1 - 0.00055 19.6 0.1 0.0013 18.5 0.1 1.6 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain HHH_5 PF14520.6 EKE42819.1 - 0.00076 20.0 0.0 0.0043 17.6 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain AAA_24 PF13479.6 EKE42819.1 - 0.0038 17.0 0.1 0.0093 15.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKE42819.1 - 0.006 16.9 0.1 0.011 16.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EKE42819.1 - 0.027 13.8 0.8 0.13 11.5 0.2 2.2 1 1 2 3 3 3 0 DnaB-like helicase C terminal domain DmpG_comm PF07836.11 EKE42819.1 - 0.041 13.4 0.2 0.081 12.5 0.2 1.5 1 0 0 1 1 1 0 DmpG-like communication domain DUF2238 PF09997.9 EKE42820.1 - 0.017 14.9 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2238) YGGT PF02325.17 EKE42820.1 - 0.17 12.4 3.0 0.57 10.6 0.6 2.3 2 0 0 2 2 2 0 YGGT family DNA_pol_A_exo1 PF01612.20 EKE42821.1 - 0.01 15.6 2.3 0.013 15.2 2.3 1.3 1 1 0 1 1 1 0 3'-5' exonuclease THOC7 PF05615.13 EKE42821.1 - 0.011 16.0 3.0 0.016 15.5 3.0 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 DUF3450 PF11932.8 EKE42821.1 - 0.027 13.8 6.6 0.035 13.4 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4771 PF15995.5 EKE42821.1 - 0.75 10.1 4.8 1.1 9.5 2.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4771) UPF0449 PF15136.6 EKE42821.1 - 0.8 10.2 5.0 1.2 9.7 5.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 FlxA PF14282.6 EKE42821.1 - 8 6.5 14.6 1.8 8.6 10.6 1.8 1 1 1 2 2 2 0 FlxA-like protein Myb_DNA-bind_4 PF13837.6 EKE42822.1 - 2.6e-05 24.5 0.1 4.5e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF573 PF04504.14 EKE42822.1 - 0.0019 18.8 0.8 0.0036 17.9 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Syntaxin_2 PF14523.6 EKE42822.1 - 0.068 13.5 4.1 0.21 12.0 4.1 1.8 1 1 0 1 1 1 0 Syntaxin-like protein DUF608 PF04685.13 EKE42822.1 - 0.097 11.8 1.1 0.12 11.5 0.7 1.5 1 1 0 1 1 1 0 Glycosyl-hydrolase family 116, catalytic region UvsW PF11637.8 EKE42823.1 - 0.28 11.3 2.0 0.32 11.1 0.6 1.8 2 0 0 2 2 2 0 ATP-dependant DNA helicase UvsW Pkinase_Tyr PF07714.17 EKE42824.1 - 5e-48 163.7 0.0 8.9e-48 162.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE42824.1 - 3.1e-43 148.1 0.6 1.3e-42 146.0 0.1 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE42824.1 - 2.8e-08 32.9 0.0 4.6e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase VSP PF03302.13 EKE42824.1 - 1.9 7.3 121.7 0.29 9.9 39.1 4.2 1 1 1 2 2 2 0 Giardia variant-specific surface protein FCH PF00611.23 EKE42826.1 - 2.7e-05 24.4 0.0 3.5e-05 24.0 0.0 1.3 1 1 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain Ssl1 PF04056.14 EKE42827.1 - 1.9e-47 161.6 0.2 2.5e-47 161.2 0.2 1.1 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EKE42827.1 - 4e-13 49.4 11.8 4e-13 49.4 11.8 2.7 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EKE42827.1 - 1.7e-11 44.7 0.1 4.7e-11 43.3 0.1 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EKE42827.1 - 0.00027 21.3 0.1 0.00063 20.0 0.1 1.6 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EKE42827.1 - 0.014 15.3 0.1 0.07 13.1 0.1 1.9 1 1 0 1 1 1 0 von Willebrand factor type A domain Synaptobrevin PF00957.21 EKE42828.1 - 8.8e-22 76.7 2.7 1.1e-21 76.4 2.7 1.1 1 0 0 1 1 1 1 Synaptobrevin Collectrin PF16959.5 EKE42828.1 - 0.0051 16.6 6.2 0.0067 16.2 6.2 1.3 1 1 0 1 1 1 1 Renal amino acid transporter DUF3827 PF12877.7 EKE42828.1 - 0.0079 14.6 3.5 0.0085 14.5 3.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) GP41 PF00517.17 EKE42828.1 - 0.03 14.2 0.7 0.032 14.1 0.7 1.0 1 0 0 1 1 1 0 Retroviral envelope protein ODV-E18 PF10717.9 EKE42828.1 - 0.037 13.9 0.3 0.046 13.6 0.3 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Orf78 PF06024.12 EKE42828.1 - 0.038 14.3 0.1 0.04 14.2 0.1 1.1 1 0 0 1 1 1 0 Orf78 (ac78) TMEM154 PF15102.6 EKE42828.1 - 0.084 12.8 0.2 0.086 12.7 0.2 1.1 1 0 0 1 1 1 0 TMEM154 protein family T2SSF PF00482.23 EKE42828.1 - 0.086 12.8 0.1 0.1 12.6 0.1 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F Shisa PF13908.6 EKE42828.1 - 0.13 12.5 0.1 0.13 12.5 0.1 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4320 PF14208.6 EKE42828.1 - 0.13 12.3 0.1 0.13 12.3 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) TMEM156 PF15106.6 EKE42828.1 - 0.13 11.7 0.3 0.14 11.5 0.3 1.0 1 0 0 1 1 1 0 TMEM156 protein family CEND1 PF15677.5 EKE42828.1 - 0.14 12.7 0.0 0.16 12.6 0.0 1.1 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 RIFIN PF02009.16 EKE42828.1 - 0.15 11.9 1.3 0.15 11.9 1.3 1.1 1 0 0 1 1 1 0 Rifin PRIMA1 PF16101.5 EKE42828.1 - 0.17 11.9 1.4 0.22 11.6 1.4 1.1 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Baculo_11_kDa PF06143.11 EKE42828.1 - 1.3 8.7 6.4 0.29 10.7 3.3 1.5 2 0 0 2 2 2 0 Baculovirus 11 kDa family DEAD PF00270.29 EKE42830.1 - 4.1e-46 156.9 0.0 1.8e-45 154.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE42830.1 - 2e-27 95.7 1.0 1.7e-25 89.5 0.3 3.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain CBF PF03914.17 EKE42831.1 - 9.4e-18 64.8 0.0 9.4e-18 64.8 0.0 3.1 3 1 0 3 3 3 1 CBF/Mak21 family NOC3p PF07540.11 EKE42831.1 - 1.5e-17 63.8 0.0 6.9e-17 61.7 0.0 2.3 2 0 0 2 2 2 1 Nucleolar complex-associated protein I_LWEQ PF01608.17 EKE42832.1 - 3.9e-40 137.6 7.8 3.9e-40 137.6 7.8 7.4 4 2 3 8 8 8 2 I/LWEQ domain DUF4407 PF14362.6 EKE42832.1 - 0.0051 16.2 19.5 0.0051 16.2 19.5 4.6 2 1 2 4 4 4 1 Domain of unknown function (DUF4407) FUSC PF04632.12 EKE42832.1 - 3.2 6.2 10.2 0.23 10.0 3.2 2.4 2 0 0 2 2 2 0 Fusaric acid resistance protein family YejG PF13989.6 EKE42832.1 - 3.5 8.1 12.4 12 6.4 2.9 3.5 2 1 0 2 2 2 0 YejG-like protein SPRY PF00622.28 EKE42833.1 - 3.1e-10 40.2 1.1 8.6e-10 38.8 1.1 1.8 1 0 0 1 1 1 1 SPRY domain GAPES3 PF17154.4 EKE42833.1 - 0.069 13.1 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain NTP_transf_2 PF01909.23 EKE42834.1 - 8.5e-07 29.2 0.0 1.7e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EKE42834.1 - 2.2e-05 24.5 0.0 5.4e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase RP854 PF17460.2 EKE42834.1 - 0.05 13.3 2.0 1.3 8.7 0.3 2.5 2 1 0 2 2 2 0 Uncharacterized protein RP854 PAP_assoc PF03828.19 EKE42834.1 - 0.072 13.3 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Cid1 family poly A polymerase Pkinase PF00069.25 EKE42835.1 - 1e-58 198.8 0.0 1.4e-58 198.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42835.1 - 1.7e-28 99.6 0.0 2.9e-28 98.9 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE42835.1 - 8.9e-05 21.9 0.0 0.0058 16.0 0.0 2.2 1 1 0 2 2 2 2 Kinase-like Choline_kinase PF01633.20 EKE42835.1 - 0.029 14.0 1.5 0.068 12.8 0.8 1.9 1 1 1 2 2 2 0 Choline/ethanolamine kinase RNA_replicase_B PF03431.13 EKE42835.1 - 0.06 11.8 0.0 0.085 11.3 0.0 1.1 1 0 0 1 1 1 0 RNA replicase, beta-chain Ras PF00071.22 EKE42837.1 - 1.9e-14 53.6 1.0 2.4e-14 53.2 1.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EKE42837.1 - 1.1e-07 32.0 0.1 2.3e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EKE42837.1 - 0.0017 17.9 0.0 0.0027 17.2 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 EKE42837.1 - 0.0028 17.4 0.0 0.63 9.8 0.0 2.2 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EKE42837.1 - 0.004 16.9 1.0 0.76 9.5 0.6 2.3 1 1 0 2 2 2 2 AAA domain GTP_EFTU PF00009.27 EKE42837.1 - 0.019 14.5 0.2 3.3 7.2 0.1 2.1 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_14 PF13173.6 EKE42837.1 - 0.024 14.7 0.2 0.061 13.4 0.2 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EKE42837.1 - 0.059 12.8 0.0 0.09 12.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.29 EKE42837.1 - 0.12 12.8 0.0 0.19 12.2 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Bromo_TP PF07524.13 EKE42838.1 - 5.9e-18 64.6 0.1 7.9e-18 64.2 0.1 1.2 1 0 0 1 1 1 1 Bromodomain associated TAF8_C PF10406.9 EKE42838.1 - 1.2e-15 57.7 0.1 3.3e-15 56.4 0.1 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP_like PF17027.5 EKE42838.1 - 4.4e-05 23.6 1.6 4.7e-05 23.5 0.2 1.8 2 0 0 2 2 2 1 Histone-fold protein CENP-T_C PF15511.6 EKE42838.1 - 0.0024 18.0 0.0 0.0043 17.1 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EKE42838.1 - 0.011 16.0 0.1 0.023 15.0 0.1 1.6 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-18kDa PF02269.16 EKE42838.1 - 0.088 12.8 0.3 0.18 11.8 0.0 1.7 2 0 0 2 2 2 0 Transcription initiation factor IID, 18kD subunit GHL6 PF14871.6 EKE42839.1 - 0.0038 17.4 0.1 0.016 15.4 0.1 2.0 2 0 0 2 2 2 1 Hypothetical glycosyl hydrolase 6 DUF2100 PF09873.9 EKE42840.1 - 0.014 15.3 0.6 0.022 14.6 0.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2100) Swi5 PF07061.11 EKE42840.1 - 0.039 14.1 0.5 0.077 13.1 0.5 1.5 1 0 0 1 1 1 0 Swi5 DNA_pol3_delta PF06144.13 EKE42840.1 - 0.17 11.7 5.6 0.052 13.3 2.7 1.5 2 0 0 2 2 2 0 DNA polymerase III, delta subunit DUF155 PF02582.14 EKE42840.1 - 0.21 11.7 1.4 0.29 11.2 1.4 1.3 1 0 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 Nod1 PF17114.5 EKE42840.1 - 0.55 10.4 4.4 2.4 8.3 1.3 2.2 1 1 1 2 2 2 0 Gef2-related medial cortical node protein Nod1 zf-RING_2 PF13639.6 EKE42841.1 - 1.6e-12 47.5 13.5 3.8e-12 46.3 13.5 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EKE42841.1 - 2.3e-09 36.9 10.0 4.9e-09 35.9 10.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EKE42841.1 - 2.7e-08 34.0 9.0 7.3e-08 32.6 9.0 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EKE42841.1 - 9.3e-08 31.9 7.2 2.2e-07 30.7 7.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 EKE42841.1 - 1.2e-07 31.4 7.5 3.3e-07 29.9 7.5 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EKE42841.1 - 1.3e-06 28.1 10.0 3.1e-06 27.0 10.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EKE42841.1 - 6e-06 26.2 5.4 1.1e-05 25.4 4.6 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EKE42841.1 - 8.1e-06 25.8 9.6 2.1e-05 24.4 9.6 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EKE42841.1 - 0.0001 22.1 9.4 0.00029 20.7 9.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Baculo_RING PF05883.11 EKE42841.1 - 0.0014 18.6 2.0 0.0027 17.7 2.0 1.4 1 0 0 1 1 1 1 Baculovirus U-box/Ring-like domain Prok-RING_4 PF14447.6 EKE42841.1 - 0.0088 15.9 11.7 0.014 15.3 9.5 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EKE42841.1 - 0.013 15.1 9.1 0.013 15.1 9.1 1.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 EKE42841.1 - 0.023 14.5 7.1 0.07 13.0 7.1 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING-like PF08746.11 EKE42841.1 - 0.086 13.2 2.4 0.27 11.6 2.4 1.8 1 0 0 1 1 1 0 RING-like domain Rtf2 PF04641.12 EKE42841.1 - 0.35 10.2 2.7 0.51 9.7 2.7 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger FANCL_C PF11793.8 EKE42841.1 - 0.56 10.4 11.6 7.7 6.8 11.6 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 EKE42841.1 - 0.64 10.2 14.6 0.078 13.2 9.5 2.2 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 EKE42841.1 - 0.83 9.8 9.1 2.3 8.4 9.1 1.8 1 0 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.6 EKE42841.1 - 1.6 8.7 8.7 0.49 10.4 3.9 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 Fibrillarin_2 PF10113.9 EKE42842.1 - 0.15 10.6 0.0 0.16 10.6 0.0 1.0 1 0 0 1 1 1 0 Fibrillarin-like archaeal protein Pkinase_Tyr PF07714.17 EKE42843.1 - 2.7e-55 187.5 0.0 3.5e-55 187.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE42843.1 - 1.4e-52 178.7 0.1 2.1e-52 178.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EKE42843.1 - 1.8e-09 36.9 0.1 2.8e-09 36.2 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EKE42843.1 - 0.041 13.2 0.0 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EKE42844.1 - 5.1e-74 249.0 0.1 5.1e-74 249.0 0.1 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42844.1 - 1.2e-56 191.9 0.0 2.3e-56 190.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE42844.1 - 0.00019 20.9 0.0 0.00057 19.3 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EKE42844.1 - 0.00025 20.5 0.5 0.00052 19.4 0.5 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EKE42844.1 - 0.00064 19.7 0.0 0.41 10.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 EKE42844.1 - 0.0032 17.1 0.2 0.0032 17.1 0.2 2.5 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 DUF1107 PF06526.12 EKE42844.1 - 0.13 12.2 6.0 4.4 7.3 0.0 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1107) NopRA1 PF16201.5 EKE42846.1 - 7.3e-08 32.2 4.5 1.5e-07 31.3 2.1 2.9 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 K1 PF02960.14 EKE42846.1 - 0.027 14.6 0.5 0.11 12.6 0.5 2.0 1 0 0 1 1 1 0 K1 glycoprotein CBFD_NFYB_HMF PF00808.23 EKE42847.1 - 1.3e-15 57.4 0.2 2.2e-15 56.7 0.2 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EKE42847.1 - 1.7e-05 25.2 0.1 1.7e-05 25.2 0.1 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TAFII28 PF04719.14 EKE42847.1 - 0.0023 18.0 0.3 0.0036 17.4 0.3 1.3 1 0 0 1 1 1 1 hTAFII28-like protein conserved region dNK PF01712.19 EKE42848.1 - 5.9e-16 58.9 1.1 5.3e-13 49.3 1.1 2.1 1 1 0 1 1 1 1 Deoxynucleoside kinase AAA_28 PF13521.6 EKE42848.1 - 2e-08 34.6 0.0 3.1e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EKE42848.1 - 3.7e-05 24.0 0.0 7.4e-05 23.0 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EKE42848.1 - 9.8e-05 22.9 0.6 0.0026 18.3 0.6 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EKE42848.1 - 0.012 16.0 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 EKE42848.1 - 0.05 13.5 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 NTPase MMR_HSR1 PF01926.23 EKE42848.1 - 0.069 13.2 0.2 0.15 12.1 0.1 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 EKE42848.1 - 0.071 13.3 0.0 0.18 12.0 0.0 1.8 2 1 1 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 EKE42848.1 - 0.088 12.7 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 EKE42848.1 - 0.093 12.2 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 EKE42848.1 - 0.11 12.2 0.0 1.2 8.9 0.0 2.0 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 EKE42848.1 - 0.16 11.3 0.0 1.7 8.0 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 EKE42848.1 - 0.17 12.4 0.1 0.23 12.0 0.1 1.4 1 1 0 1 1 1 0 ABC transporter WD40 PF00400.32 EKE42850.1 - 2.1e-05 25.2 0.0 0.23 12.4 0.0 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EKE42850.1 - 0.0009 19.5 0.0 0.46 10.8 0.0 3.2 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EKE42850.1 - 0.004 17.1 0.1 0.078 12.8 0.0 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EKE42850.1 - 0.022 14.1 1.3 5.2 6.3 0.0 2.8 3 0 0 3 3 3 0 WD40-like domain IKI3 PF04762.12 EKE42850.1 - 0.022 12.8 0.0 0.03 12.3 0.0 1.1 1 0 0 1 1 1 0 IKI3 family Nbas_N PF15492.6 EKE42850.1 - 0.034 13.5 0.0 0.089 12.1 0.0 1.7 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 EKE42850.1 - 0.049 12.3 0.2 0.16 10.6 0.1 1.7 1 1 1 2 2 2 0 Nucleoporin Nup120/160 CNH PF00780.22 EKE42850.1 - 0.085 12.4 0.0 0.26 10.8 0.1 1.7 1 1 0 1 1 1 0 CNH domain Tmemb_18A PF09771.9 EKE42851.1 - 0.05 14.0 1.7 0.68 10.3 0.1 2.7 3 0 0 3 3 3 0 Transmembrane protein 188 T3SS_needle_F PF09392.10 EKE42851.1 - 0.36 11.1 12.8 0.39 10.9 0.0 3.9 4 1 0 4 4 4 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Phycobilisome PF00502.19 EKE42851.1 - 0.6 10.0 6.2 0.57 10.1 0.1 3.1 3 1 0 3 3 3 0 Phycobilisome protein TssC PF17541.2 EKE42851.1 - 4.2 6.1 22.0 0.053 12.3 9.5 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssC, VipB DENN PF02141.21 EKE42852.1 - 9.7e-30 103.9 0.6 5e-29 101.6 0.4 2.2 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 EKE42852.1 - 2.4e-07 31.4 0.0 8.3e-07 29.7 0.0 2.0 1 0 0 1 1 1 1 uDENN domain C2 PF00168.30 EKE42852.1 - 0.0014 18.9 0.0 0.0051 17.1 0.0 2.0 2 0 0 2 2 2 1 C2 domain dDENN PF03455.19 EKE42852.1 - 0.014 15.4 0.8 0.041 13.9 0.8 1.8 1 0 0 1 1 1 0 dDENN domain Chromo PF00385.24 EKE42853.1 - 9.2e-06 25.5 1.7 0.00053 19.8 0.5 3.4 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain UPF0524 PF15823.5 EKE42853.1 - 0.34 10.3 8.8 1.3 8.3 8.8 2.0 1 0 0 1 1 1 0 UPF0524 of C3orf70 Mlh1_C PF16413.5 EKE42854.1 - 0.0037 16.7 0.3 0.0054 16.1 0.3 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus Corona_NS2A PF05213.12 EKE42854.1 - 0.049 13.0 0.4 0.08 12.3 0.4 1.3 1 0 0 1 1 1 0 Coronavirus NS2A protein DUF1840 PF08895.11 EKE42854.1 - 0.08 13.3 3.1 0.19 12.0 3.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) LMBR1 PF04791.16 EKE42854.1 - 2 7.2 4.5 2 7.2 4.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Med10 PF09748.9 EKE42855.1 - 6.2e-10 39.1 0.0 7.7e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex LCD1 PF09798.9 EKE42857.1 - 0.15 10.6 0.6 0.16 10.4 0.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Acetyltransf_10 PF13673.7 EKE42858.1 - 1.1e-15 57.7 0.0 1.5e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EKE42858.1 - 1.5e-07 31.7 0.2 1.9e-07 31.4 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EKE42858.1 - 9.9e-07 29.0 0.2 1.2e-06 28.8 0.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_CG PF14542.6 EKE42858.1 - 0.0012 18.9 0.0 0.0019 18.3 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase PolyA_pol PF01743.20 EKE42859.1 - 1.1e-26 93.7 0.1 2.3e-26 92.7 0.1 1.6 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EKE42859.1 - 4.1e-06 26.5 0.0 1.1e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 EKE42859.1 - 0.074 13.0 0.0 2.9 7.9 0.0 2.6 2 0 0 2 2 2 0 tRNA nucleotidyltransferase domain 2 putative SEP PF08059.13 EKE42859.1 - 0.17 12.5 0.0 0.46 11.1 0.0 1.7 1 0 0 1 1 1 0 SEP domain Pyr_redox_2 PF07992.14 EKE42860.1 - 2.1e-21 76.4 3.2 3e-21 75.9 3.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 EKE42860.1 - 1.1e-16 60.9 2.2 1.1e-16 60.9 2.2 2.1 2 0 0 2 2 2 1 BFD-like [2Fe-2S] binding domain Thi4 PF01946.17 EKE42860.1 - 2.7e-08 33.3 3.6 1.5e-07 30.9 0.0 2.5 3 0 0 3 3 3 1 Thi4 family Pyr_redox PF00070.27 EKE42860.1 - 2.9e-08 34.2 3.4 0.0036 17.8 0.4 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EKE42860.1 - 4.9e-07 29.9 0.7 1.8e-05 24.8 0.5 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EKE42860.1 - 2.6e-06 27.1 0.9 5.8e-06 25.9 0.9 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EKE42860.1 - 2.7e-05 23.1 0.6 2.7e-05 23.1 0.6 2.5 2 1 2 4 4 4 1 HI0933-like protein SO_alpha_A3 PF17806.1 EKE42860.1 - 2.8e-05 24.4 0.0 6.1e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Sarcosine oxidase A3 domain FAD_binding_2 PF00890.24 EKE42860.1 - 0.00027 20.1 1.8 0.00027 20.1 1.8 2.6 3 1 1 4 4 4 1 FAD binding domain NAD_binding_9 PF13454.6 EKE42860.1 - 0.00063 19.8 0.7 0.0063 16.5 0.2 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 EKE42860.1 - 0.0022 17.6 7.4 0.0045 16.6 0.7 2.7 2 1 1 3 3 3 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EKE42860.1 - 0.0024 17.0 0.5 0.0024 17.0 0.5 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein ELFV_dehydrog PF00208.21 EKE42860.1 - 0.0035 17.1 0.1 0.0084 15.9 0.1 1.6 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_7 PF13241.6 EKE42860.1 - 0.0067 16.9 0.5 6.1 7.3 0.1 2.9 2 0 0 2 2 2 2 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 EKE42860.1 - 0.0095 15.2 2.5 0.057 12.7 0.3 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EKE42860.1 - 0.095 11.5 0.4 0.15 10.9 0.4 1.3 1 0 0 1 1 1 0 Tryptophan halogenase 2-Hacid_dh_C PF02826.19 EKE42860.1 - 0.12 11.8 0.4 0.23 10.8 0.1 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K_oxygenase PF13434.6 EKE42860.1 - 0.13 11.3 0.0 0.27 10.3 0.0 1.4 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 EKE42860.1 - 0.29 10.1 2.5 0.54 9.3 1.5 1.9 1 1 1 2 2 2 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EKE42860.1 - 0.9 8.7 5.5 0.4 9.9 0.1 2.7 3 0 0 3 3 3 0 FAD binding domain MFS_1 PF07690.16 EKE42861.1 - 2.9e-38 131.7 20.5 9.8e-24 83.9 6.9 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EKE42861.1 - 4.9e-07 28.9 12.8 4.9e-07 28.9 12.8 2.8 1 1 1 3 3 3 1 MFS_1 like family Sugar_tr PF00083.24 EKE42861.1 - 1.6e-06 27.3 34.2 0.0014 17.6 10.5 2.5 1 1 0 2 2 2 2 Sugar (and other) transporter DUF4834 PF16118.5 EKE42861.1 - 0.0065 17.4 11.7 0.89 10.6 0.7 4.0 4 0 0 4 4 4 2 Domain of unknown function (DUF4834) MFS_4 PF06779.14 EKE42861.1 - 0.014 14.7 1.1 0.014 14.7 1.1 2.2 2 0 0 2 2 2 0 Uncharacterised MFS-type transporter YbfB YwiC PF14256.6 EKE42861.1 - 0.031 14.6 10.3 0.21 11.9 4.0 3.0 3 0 0 3 3 3 0 YwiC-like protein Phtf-FEM1B_bdg PF12129.8 EKE42861.1 - 0.21 11.4 9.1 1.8 8.4 2.1 3.2 3 0 0 3 3 3 0 Male germ-cell putative homeodomain transcription factor Nodulin-like PF06813.13 EKE42861.1 - 4.1 6.8 21.3 0.023 14.2 8.7 3.0 3 1 1 4 4 4 0 Nodulin-like DUF2070 PF09843.9 EKE42861.1 - 5.4 5.2 25.2 0.22 9.8 12.5 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) RhoGAP PF00620.27 EKE42862.1 - 1.4e-13 50.9 0.0 3.2e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain LemA PF04011.12 EKE42862.1 - 0.034 14.0 0.0 0.083 12.7 0.0 1.6 1 0 0 1 1 1 0 LemA family TPR_MLP1_2 PF07926.12 EKE42863.1 - 0.0072 16.4 15.3 0.0072 16.4 15.3 1.8 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 EKE42863.1 - 0.019 15.0 2.3 0.019 15.0 2.3 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus V_ATPase_I PF01496.19 EKE42863.1 - 0.023 12.6 13.1 0.025 12.5 13.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLZ PF16526.5 EKE42863.1 - 0.028 14.8 2.3 0.028 14.8 2.3 3.2 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SlyX PF04102.12 EKE42863.1 - 0.24 12.1 10.2 1.5 9.5 4.3 2.9 1 1 1 2 2 2 0 SlyX DDHD PF02862.17 EKE42863.1 - 0.25 11.5 5.3 0.31 11.2 5.3 1.3 1 0 0 1 1 1 0 DDHD domain DUF4407 PF14362.6 EKE42863.1 - 7.9 5.7 14.1 11 5.2 14.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TCTP PF00838.17 EKE42864.1 - 8.6e-55 185.6 7.2 9.7e-55 185.4 7.2 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein CBM_4_9 PF02018.17 EKE42865.1 - 2.1e-08 34.5 0.6 2.1e-08 34.5 0.6 2.7 4 0 0 4 4 4 1 Carbohydrate binding domain Peptidase_M18 PF02127.15 EKE42866.1 - 2.4e-114 382.5 0.0 4.6e-114 381.6 0.0 1.4 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EKE42866.1 - 0.0041 16.2 0.1 0.27 10.2 0.0 2.1 1 1 1 2 2 2 2 M42 glutamyl aminopeptidase Pox_EPC_I2-L1 PF12575.8 EKE42866.1 - 0.12 12.6 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 Utp12 PF04003.12 EKE42868.1 - 3.2e-17 62.8 1.0 6e-17 61.9 1.0 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EKE42868.1 - 0.16 12.3 2.9 0.36 11.2 0.1 3.0 4 1 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain PQ-loop PF04193.14 EKE42871.1 - 1.4e-16 60.0 9.7 1.5e-09 37.5 0.4 3.6 4 0 0 4 4 4 2 PQ loop repeat Alkyl_sulf_dimr PF14863.6 EKE42872.1 - 5.7e-51 172.6 0.1 8.8e-51 172.0 0.1 1.3 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Alkyl_sulf_C PF14864.6 EKE42872.1 - 7.4e-16 58.6 0.2 1.4e-15 57.6 0.2 1.5 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Lactamase_B PF00753.27 EKE42872.1 - 5.4e-14 52.7 0.0 1.5e-12 47.9 0.0 2.4 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EKE42872.1 - 3.9e-05 23.3 0.0 6.6e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain ANAPC3 PF12895.7 EKE42872.1 - 0.0047 17.1 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 RdgC PF04381.12 EKE42872.1 - 0.1 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Putative exonuclease, RdgC YlbD_coat PF14071.6 EKE42873.1 - 0.066 13.5 0.5 0.67 10.2 0.1 2.8 2 0 0 2 2 2 0 Putative coat protein LUD_dom PF02589.15 EKE42873.1 - 0.073 12.8 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 LUD domain TFIID-31kDa PF02291.15 EKE42874.1 - 1.6e-13 50.8 0.0 2.8e-13 50.0 0.0 1.4 1 1 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DUF3113 PF11310.8 EKE42875.1 - 0.045 13.7 0.0 0.098 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3113) DUF92 PF01940.16 EKE42876.1 - 1.3e-43 149.1 6.3 1.6e-43 148.8 6.3 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 Gpi16 PF04113.14 EKE42877.1 - 7.8e-19 67.5 0.9 2.3e-16 59.4 0.1 2.8 2 1 0 2 2 2 2 Gpi16 subunit, GPI transamidase component DUF1835 PF08874.10 EKE42878.1 - 0.089 13.0 1.8 0.11 12.7 1.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1835) ORC_WH_C PF18137.1 EKE42878.1 - 1.5 8.9 7.7 2.5 8.2 7.7 1.6 1 1 0 1 1 1 0 Origin recognition complex winged helix C-terminal Silic_transp PF03842.13 EKE42878.1 - 8.3 4.6 5.8 8.9 4.5 5.8 1.0 1 0 0 1 1 1 0 Silicon transporter zf-C3HC4_3 PF13920.6 EKE42879.1 - 1.4e-10 40.8 6.9 2.1e-10 40.3 6.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EKE42879.1 - 7.7e-09 35.3 10.0 2.6e-08 33.6 10.2 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EKE42879.1 - 7.8e-09 35.4 10.7 1.8e-08 34.3 4.6 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EKE42879.1 - 1.3e-08 35.0 10.5 2.3e-08 34.2 10.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EKE42879.1 - 2.2e-08 33.8 9.9 4.3e-08 32.9 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EKE42879.1 - 1.2e-07 31.8 9.8 2.4e-07 30.8 9.8 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EKE42879.1 - 3e-06 27.1 11.3 4.3e-06 26.6 10.3 1.8 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EKE42879.1 - 4.1e-06 26.6 11.2 6.9e-06 25.8 10.4 1.8 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-P11 PF03854.14 EKE42879.1 - 0.00055 19.5 4.5 0.0012 18.5 4.5 1.6 1 0 0 1 1 1 1 P-11 zinc finger zf-RING_11 PF17123.5 EKE42879.1 - 0.3 10.9 9.0 1.4 8.8 5.6 2.8 2 1 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 EKE42879.1 - 0.41 11.0 10.0 1.2 9.4 10.0 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EKE42879.1 - 0.45 10.6 6.0 0.97 9.5 6.0 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EKE42879.1 - 0.53 10.1 8.1 0.62 9.9 6.3 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 EKE42879.1 - 0.62 10.0 7.0 2.3 8.1 5.9 2.0 1 1 1 2 2 2 0 zf-RING of BARD1-type protein Zn-ribbon_8 PF09723.10 EKE42879.1 - 0.7 10.1 6.4 1.3 9.2 2.0 2.5 2 0 0 2 2 2 0 Zinc ribbon domain RecR PF02132.15 EKE42879.1 - 2 8.0 9.7 4.2 7.0 3.9 2.4 2 0 0 2 2 2 0 RecR protein TF_Zn_Ribbon PF08271.12 EKE42879.1 - 2.7 7.6 7.2 3.8 7.1 1.7 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding IBR PF01485.21 EKE42879.1 - 4.8 7.5 11.6 1.8 8.8 6.5 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Stealth_CR2 PF11380.8 EKE42882.1 - 3.6e-32 110.7 0.0 7.4e-32 109.7 0.0 1.5 1 0 0 1 1 1 1 Stealth protein CR2, conserved region 2 Stealth_CR1 PF17101.5 EKE42882.1 - 8.1e-08 31.9 0.0 1.6e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Stealth_CR3 PF17102.5 EKE42882.1 - 6.6e-07 29.1 0.1 1.3e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Stealth_CR4 PF17103.5 EKE42882.1 - 0.001 18.9 0.3 0.001 18.9 0.3 2.0 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 RNA_pol_Rpb5_C PF01191.19 EKE42883.1 - 1.2e-33 114.8 0.5 2.7e-33 113.7 0.5 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EKE42883.1 - 3.4e-20 72.4 0.0 9e-20 71.1 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain POTRA_2 PF08479.11 EKE42883.1 - 0.13 12.1 0.0 3.4 7.6 0.0 2.5 2 0 0 2 2 2 0 POTRA domain, ShlB-type RNA_pol_Rpb1_R PF05001.13 EKE42884.1 - 0.15 12.4 1.2 0.15 12.4 1.2 3.0 3 0 0 3 3 3 0 RNA polymerase Rpb1 C-terminal repeat LEAP-2 PF07359.11 EKE42884.1 - 3.1 7.7 5.5 4.4 7.2 0.1 2.8 3 1 0 3 3 3 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) FAT PF02259.23 EKE42885.1 - 4.9e-47 160.8 27.5 2.3e-46 158.6 17.6 2.9 2 0 0 2 2 2 2 FAT domain FRB_dom PF08771.11 EKE42885.1 - 8.2e-25 87.1 1.1 8.2e-25 87.1 1.1 6.2 5 1 0 6 6 6 1 FKBP12-rapamycin binding domain DUF3385 PF11865.8 EKE42885.1 - 2e-21 76.6 1.0 2e-21 76.6 1.0 6.4 6 1 0 7 7 7 1 Domain of unknown function (DUF3385) U3snoRNP10 PF12397.8 EKE42885.1 - 1.8 8.9 7.5 4.7 7.6 0.5 4.2 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 10 TAN PF11640.8 EKE42885.1 - 2.4 8.3 8.7 0.45 10.6 0.9 3.9 3 0 0 3 3 3 0 Telomere-length maintenance and DNA damage repair Myb_DNA-binding PF00249.31 EKE42887.1 - 5.6e-29 100.1 3.0 3e-15 56.1 0.4 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EKE42887.1 - 1e-19 70.5 4.6 2.5e-12 46.9 0.5 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EKE42887.1 - 1.4e-08 34.5 1.1 0.0015 18.4 0.1 2.2 1 1 1 2 2 2 2 Myb DNA-binding like SANT_DAMP1_like PF16282.5 EKE42887.1 - 0.0046 17.1 0.3 1.2 9.3 0.1 2.2 1 1 1 2 2 2 2 SANT/Myb-like domain of DAMP1 SLIDE PF09111.10 EKE42887.1 - 0.0056 16.7 0.8 1.4 9.0 0.1 2.5 1 1 1 2 2 2 2 SLIDE DUF573 PF04504.14 EKE42887.1 - 0.02 15.6 0.7 0.73 10.5 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function, DUF573 DUF3385 PF11865.8 EKE42888.1 - 0.0053 16.7 0.1 0.0053 16.7 0.1 3.9 5 0 0 5 5 5 1 Domain of unknown function (DUF3385) DUF465 PF04325.13 EKE42888.1 - 0.025 14.6 1.2 2.6 8.2 0.0 3.5 2 0 0 2 2 2 0 Protein of unknown function (DUF465) DUF4508 PF14969.6 EKE42888.1 - 0.47 10.7 2.9 4.4 7.6 0.2 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4508) Ric8 PF10165.9 EKE42889.1 - 0.00045 19.4 1.4 1.3 8.0 0.0 3.2 2 1 1 3 3 3 2 Guanine nucleotide exchange factor synembryn DUSP PF06337.12 EKE42889.1 - 0.021 15.5 1.9 0.22 12.1 0.1 2.7 2 0 0 2 2 2 0 DUSP domain DUF4522 PF15022.6 EKE42890.1 - 0.012 15.9 3.9 0.19 12.0 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4522) CH PF00307.31 EKE42891.1 - 4.3e-12 46.2 6.7 6.3e-08 32.8 0.1 3.2 3 0 0 3 3 3 2 Calponin homology (CH) domain Caldesmon PF02029.15 EKE42891.1 - 0.093 11.5 55.8 0.13 11.0 55.8 1.1 1 0 0 1 1 1 0 Caldesmon Hamartin PF04388.12 EKE42891.1 - 0.097 11.3 28.0 0.13 10.9 28.0 1.1 1 0 0 1 1 1 0 Hamartin protein SOBP PF15279.6 EKE42891.1 - 1.2 9.7 25.1 1.8 9.1 25.1 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Pkinase PF00069.25 EKE42892.1 - 1.3e-16 60.8 1.0 1.3e-16 60.8 1.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42892.1 - 8.9e-10 38.3 0.2 1.2e-09 37.9 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EKE42892.1 - 9.8e-08 32.2 0.9 2.2e-07 31.1 0.1 1.9 2 1 0 2 2 2 1 FHA domain DSHCT PF08148.12 EKE42893.1 - 2.9e-45 153.9 0.2 7.9e-45 152.5 0.0 1.8 2 0 0 2 2 2 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.6 EKE42893.1 - 4.8e-44 151.3 1.3 5.6e-44 151.1 0.6 1.5 2 0 0 2 2 2 1 rRNA-processing arch domain DUF4559 PF15112.6 EKE42893.1 - 0.66 9.6 4.7 0.21 11.2 1.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) DUF641 PF04859.12 EKE42893.1 - 0.77 10.1 5.4 0.26 11.6 0.3 2.2 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) WD40 PF00400.32 EKE42894.1 - 9.5e-25 86.4 8.6 8.7e-05 23.2 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat Sof1 PF04158.14 EKE42894.1 - 9.4e-17 61.1 0.7 2e-16 60.0 0.7 1.6 1 0 0 1 1 1 1 Sof1-like domain ANAPC4_WD40 PF12894.7 EKE42894.1 - 8.2e-05 22.8 0.0 1.4 9.3 0.0 4.0 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EKE42894.1 - 0.0057 15.4 0.1 0.014 14.1 0.1 1.7 1 1 0 1 1 1 1 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EKE42894.1 - 0.019 15.0 0.0 18 5.4 0.0 3.5 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region PHZA_PHZB PF03284.13 EKE42894.1 - 0.033 13.8 0.2 0.11 12.1 0.1 1.8 2 0 0 2 2 2 0 Phenazine biosynthesis protein A/B Ge1_WD40 PF16529.5 EKE42894.1 - 0.098 11.6 0.3 22 3.9 0.1 2.9 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RhoGAP PF00620.27 EKE42895.1 - 3.2e-29 101.7 0.1 9.4e-29 100.2 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain HSM3_C PF18794.1 EKE42895.1 - 0.0093 15.6 0.3 0.02 14.5 0.3 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein HSM3, C terminal domain PCIF1_WW PF12237.8 EKE42895.1 - 0.014 15.0 0.9 0.14 11.7 0.4 2.5 2 1 0 2 2 2 0 Phosphorylated CTD interacting factor 1 WW domain Fumerase PF05681.14 EKE42896.1 - 1.8e-83 280.1 0.0 2.5e-83 279.6 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.12 EKE42896.1 - 1.5e-80 269.4 0.0 2.1e-80 268.9 0.0 1.2 1 0 0 1 1 1 1 Fumarase C-terminus Gemini_AL1 PF00799.20 EKE42897.1 - 2.7e-05 24.5 2.4 2.7e-05 24.5 2.4 2.4 3 0 0 3 3 3 1 Geminivirus Rep catalytic domain Peptidase_C25_C PF03785.14 EKE42897.1 - 0.15 11.9 0.6 0.8 9.6 0.5 2.1 2 0 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain Cullin PF00888.22 EKE42898.1 - 1.4e-89 301.4 32.8 2e-89 300.9 32.8 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EKE42898.1 - 5.2e-21 74.5 0.7 5.2e-21 74.5 0.7 3.1 3 0 0 3 3 3 1 Cullin protein neddylation domain HTH_Mga PF08280.11 EKE42898.1 - 0.0071 16.4 0.5 0.0071 16.4 0.5 2.4 2 0 0 2 2 2 1 M protein trans-acting positive regulator (MGA) HTH domain TrmB PF01978.19 EKE42898.1 - 0.11 12.4 0.2 15 5.5 0.1 2.6 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Phage_rep_org_N PF09681.10 EKE42898.1 - 0.16 11.9 5.0 1.7 8.6 0.3 3.5 3 0 0 3 3 3 0 N-terminal phage replisome organiser (Phage_rep_org_N) DUF953 PF06110.11 EKE42899.1 - 0.0013 18.3 0.1 0.0053 16.4 0.1 2.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) V-SNARE_C PF12352.8 EKE42900.1 - 2e-09 37.6 2.8 5.2e-09 36.2 2.5 1.8 1 1 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EKE42900.1 - 6.7e-06 25.9 0.6 1e-05 25.3 0.6 1.3 1 0 0 1 1 1 1 Sec20 OATP PF03137.20 EKE42900.1 - 0.0087 14.4 0.1 0.0087 14.4 0.1 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF5089 PF17002.5 EKE42900.1 - 0.0097 15.8 0.8 0.011 15.6 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5089) TRP PF06011.12 EKE42900.1 - 0.011 14.6 0.0 0.011 14.6 0.0 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel RIFIN PF02009.16 EKE42900.1 - 0.013 15.4 0.1 0.015 15.2 0.1 1.2 1 0 0 1 1 1 0 Rifin ETRAMP PF09716.10 EKE42900.1 - 0.03 14.4 0.6 0.069 13.2 0.6 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF2721 PF11026.8 EKE42900.1 - 0.054 13.4 0.1 0.076 12.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF2207 PF09972.9 EKE42900.1 - 0.084 11.6 0.2 0.094 11.5 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Synaptobrevin PF00957.21 EKE42900.1 - 0.091 12.6 4.7 0.17 11.7 4.7 1.6 1 1 0 1 1 1 0 Synaptobrevin DUF4972 PF16342.5 EKE42900.1 - 0.12 12.1 2.5 0.066 12.9 0.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4972) Insulin_TMD PF17870.1 EKE42900.1 - 0.14 12.3 9.2 0.22 11.6 9.2 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Fusion_gly PF00523.18 EKE42900.1 - 0.16 10.2 4.2 2.1 6.5 4.1 2.1 1 1 0 1 1 1 0 Fusion glycoprotein F0 TBCA PF02970.16 EKE42900.1 - 0.2 12.0 3.3 0.81 10.1 3.3 1.8 1 1 0 1 1 1 0 Tubulin binding cofactor A FeoB_associated PF12669.7 EKE42900.1 - 10 6.6 7.0 15 6.1 7.0 1.3 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein DUF4404 PF14357.6 EKE42901.1 - 0.58 10.8 17.4 1.8 9.3 4.1 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) EAP30 PF04157.16 EKE42901.1 - 0.9 8.8 7.4 1.4 8.1 0.1 3.1 2 1 1 3 3 3 0 EAP30/Vps36 family DUF3450 PF11932.8 EKE42901.1 - 6.3 6.0 23.0 7.8 5.7 3.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Synaptobrevin PF00957.21 EKE42902.1 - 4.2e-22 77.7 8.8 5.3e-22 77.4 8.8 1.1 1 0 0 1 1 1 1 Synaptobrevin TMEM154 PF15102.6 EKE42902.1 - 1.1e-05 25.3 2.9 1.2e-05 25.2 2.9 1.1 1 0 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 EKE42902.1 - 0.00059 20.1 2.9 0.00067 19.9 2.9 1.1 1 0 0 1 1 1 1 Orf78 (ac78) Baculo_F PF12259.8 EKE42902.1 - 0.0013 17.4 4.3 0.0014 17.2 4.3 1.0 1 0 0 1 1 1 1 Baculovirus F protein Ferlin_C PF16165.5 EKE42902.1 - 0.0046 16.9 2.1 0.0057 16.6 2.1 1.2 1 0 0 1 1 1 1 Ferlin C-terminus Shisa PF13908.6 EKE42902.1 - 0.0055 17.0 0.3 0.0063 16.8 0.3 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator LRRC37AB_C PF14914.6 EKE42902.1 - 0.0062 16.4 2.4 0.007 16.3 2.4 1.1 1 0 0 1 1 1 1 LRRC37A/B like protein 1 C-terminal domain Glycophorin_A PF01102.18 EKE42902.1 - 0.0063 16.7 0.5 0.0064 16.7 0.5 1.1 1 0 0 1 1 1 1 Glycophorin A DUF2207 PF09972.9 EKE42902.1 - 0.0066 15.3 0.9 0.0066 15.3 0.9 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) PRIMA1 PF16101.5 EKE42902.1 - 0.0091 16.0 2.7 0.011 15.7 2.7 1.2 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 GPDPase_memb PF10110.9 EKE42902.1 - 0.012 14.4 3.9 0.015 14.1 3.9 1.0 1 0 0 1 1 1 0 Membrane domain of glycerophosphoryl diester phosphodiesterase GP41 PF00517.17 EKE42902.1 - 0.012 15.5 5.7 0.013 15.4 5.7 1.0 1 0 0 1 1 1 0 Retroviral envelope protein Mid2 PF04478.12 EKE42902.1 - 0.015 15.1 0.2 0.016 15.1 0.2 1.2 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor LAP1C PF05609.12 EKE42902.1 - 0.019 14.1 0.7 0.02 14.0 0.7 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RIFIN PF02009.16 EKE42902.1 - 0.019 14.8 6.7 0.021 14.7 6.7 1.0 1 0 0 1 1 1 0 Rifin DUF3619 PF12279.8 EKE42902.1 - 0.028 14.8 0.2 0.034 14.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) Amnionless PF14828.6 EKE42902.1 - 0.037 12.9 0.3 0.039 12.8 0.3 1.0 1 0 0 1 1 1 0 Amnionless Sigma_reg_N PF13800.6 EKE42902.1 - 0.052 13.9 3.4 0.085 13.2 3.4 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Hanta_G2 PF01561.16 EKE42902.1 - 0.079 11.6 1.2 0.084 11.5 1.2 1.0 1 0 0 1 1 1 0 Hantavirus glycoprotein G2 TBCA PF02970.16 EKE42902.1 - 0.094 13.1 0.6 0.12 12.7 0.6 1.1 1 0 0 1 1 1 0 Tubulin binding cofactor A Collectrin PF16959.5 EKE42902.1 - 0.14 11.9 7.8 0.17 11.6 7.8 1.3 1 1 0 1 1 1 0 Renal amino acid transporter DUF515 PF04415.12 EKE42902.1 - 0.39 9.1 5.7 0.38 9.1 5.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF515) TMIE PF16038.5 EKE42902.1 - 0.41 10.5 8.8 0.15 11.9 6.0 1.7 1 1 1 2 2 2 0 TMIE protein DUF4199 PF13858.6 EKE42902.1 - 0.46 10.9 6.7 4 7.8 7.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4199) Use1 PF09753.9 EKE42902.1 - 0.55 9.9 4.3 0.6 9.8 4.3 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 DUF3827 PF12877.7 EKE42902.1 - 1 7.6 13.3 1.3 7.3 13.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3827) Baculo_11_kDa PF06143.11 EKE42902.1 - 1.7 8.3 10.1 3.2 7.4 10.1 1.7 1 1 0 1 1 1 0 Baculovirus 11 kDa family EphA2_TM PF14575.6 EKE42902.1 - 2.6 9.0 7.3 1 10.3 4.9 1.5 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Insulin_TMD PF17870.1 EKE42902.1 - 4 7.6 10.1 7.6 6.7 10.1 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment AP-5_subunit_s1 PF15001.6 EKE42903.1 - 0.004 17.2 0.2 0.0066 16.5 0.0 1.5 2 0 0 2 2 2 1 AP-5 complex subunit sigma-1 Clat_adaptor_s PF01217.20 EKE42903.1 - 0.0043 17.0 1.3 0.0064 16.4 1.3 1.3 1 1 0 1 1 1 1 Clathrin adaptor complex small chain AIF_C PF14721.6 EKE42904.1 - 1.5 9.2 4.2 3.2 8.1 4.2 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term PTCB-BRCT PF12738.7 EKE42905.1 - 4.8e-17 61.7 0.0 5.8e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EKE42905.1 - 1.3e-12 47.9 0.0 1.5e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EKE42905.1 - 8.7e-09 35.7 0.0 1e-08 35.4 0.0 1.1 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 EKE42905.1 - 3.3e-05 23.9 0.0 5e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF4985 PF16373.5 EKE42905.1 - 0.096 13.2 0.0 0.1 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function PTP_tm PF18861.1 EKE42905.1 - 0.2 11.7 0.0 0.23 11.4 0.0 1.3 1 1 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Pkinase PF00069.25 EKE42906.1 - 6.2e-26 91.3 0.1 7.3e-26 91.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42906.1 - 8.5e-14 51.4 0.0 9.5e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EKE42906.1 - 1.3e-07 30.8 0.1 1.7e-07 30.4 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EKE42906.1 - 0.00049 20.1 0.0 0.00082 19.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EKE42906.1 - 0.0089 15.4 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2947 PF11163.8 EKE42908.1 - 0.013 15.3 1.6 0.018 14.9 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2947) NPV_P10 PF05531.12 EKE42908.1 - 0.059 13.8 10.2 1.8 9.1 0.3 4.3 3 2 0 4 4 4 0 Nucleopolyhedrovirus P10 protein UNC-50 PF05216.13 EKE42909.1 - 1.5e-30 106.5 30.1 1.7e-30 106.2 30.1 1.0 1 0 0 1 1 1 1 UNC-50 family EF-hand_4 PF12763.7 EKE42910.1 - 4.1e-06 26.7 0.8 0.00052 19.9 0.4 2.9 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.6 EKE42910.1 - 0.00017 21.3 3.8 0.0094 15.8 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EKE42910.1 - 0.00038 19.8 8.8 0.033 13.8 3.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EKE42910.1 - 0.0019 18.6 1.3 0.28 11.7 0.2 2.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EKE42910.1 - 0.028 14.3 6.6 0.064 13.2 2.3 3.0 2 1 1 3 3 3 0 EF-hand domain EF-hand_5 PF13202.6 EKE42910.1 - 0.1 12.1 5.3 1.8 8.2 4.2 2.8 2 0 0 2 2 2 0 EF hand DUF1664 PF07889.12 EKE42910.1 - 0.42 10.7 1.6 0.91 9.6 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4286 PF14114.6 EKE42911.1 - 0.057 13.9 0.1 0.16 12.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4286) VWA PF00092.28 EKE42913.1 - 0.00024 21.4 0.7 0.00038 20.7 0.7 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EKE42913.1 - 0.0016 19.1 0.1 0.0037 17.9 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 EKE42913.1 - 0.0038 17.4 0.3 0.012 15.7 0.2 1.8 1 1 0 1 1 1 1 vWA found in TerF C terminus VWA_CoxE PF05762.14 EKE42913.1 - 0.045 13.2 0.0 1.4 8.3 0.0 2.1 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein AAA_5 PF07728.14 EKE42914.1 - 1.8e-130 429.7 4.3 9.9e-24 83.9 0.0 11.2 10 2 2 12 12 10 9 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EKE42914.1 - 5.7e-32 110.3 0.0 2.1e-09 37.3 0.0 8.5 10 0 0 10 10 7 3 ATPase family associated with various cellular activities (AAA) AAA_lid_5 PF17865.1 EKE42914.1 - 1.7e-31 108.5 0.0 2e-30 105.0 0.0 3.0 2 0 0 2 2 2 1 Midasin AAA lid domain AAA PF00004.29 EKE42914.1 - 7.4e-29 100.8 9.0 5e-05 23.7 0.1 8.1 8 0 0 8 8 6 5 ATPase family associated with various cellular activities (AAA) AAA_lid_7 PF17867.1 EKE42914.1 - 1.9e-27 95.5 1.9 4.7e-11 42.8 0.0 5.2 5 0 0 5 5 5 3 Midasin AAA lid domain AAA_7 PF12775.7 EKE42914.1 - 1.4e-25 89.8 4.6 1.1e-05 25.0 0.1 6.6 6 0 0 6 6 6 5 P-loop containing dynein motor region AAA_22 PF13401.6 EKE42914.1 - 4.4e-23 82.1 0.0 0.00057 20.2 0.0 7.4 6 0 0 6 6 6 4 AAA domain AAA_16 PF13191.6 EKE42914.1 - 1.1e-21 78.0 0.1 0.0011 19.4 0.0 7.3 6 1 0 6 6 6 4 AAA ATPase domain Dynein_heavy PF03028.15 EKE42914.1 - 8.9e-21 74.2 0.1 0.025 14.7 0.0 9.4 9 0 0 9 9 8 4 Dynein heavy chain region D6 P-loop domain TsaE PF02367.17 EKE42914.1 - 3.6e-17 62.5 1.6 0.057 13.4 0.0 6.7 6 0 0 6 6 6 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EKE42914.1 - 4e-17 63.0 12.1 0.023 15.2 0.0 8.7 7 0 0 7 7 6 4 AAA domain RNA_helicase PF00910.22 EKE42914.1 - 6.5e-15 55.4 4.2 0.21 12.0 0.0 8.0 7 0 0 7 7 6 3 RNA helicase ABC_tran PF00005.27 EKE42914.1 - 8.9e-15 55.4 12.8 0.014 15.9 0.1 8.0 7 0 0 7 7 6 3 ABC transporter AAA_6 PF12774.7 EKE42914.1 - 4.2e-14 52.3 16.6 0.0071 15.4 0.1 9.1 9 1 0 9 9 8 4 Hydrolytic ATP binding site of dynein motor region AAA_30 PF13604.6 EKE42914.1 - 9.8e-14 51.5 0.0 0.021 14.5 0.0 6.5 7 0 0 7 7 6 3 AAA domain AAA_14 PF13173.6 EKE42914.1 - 3.7e-13 49.7 14.6 0.018 15.1 0.0 9.8 8 1 0 8 8 7 3 AAA domain Sigma54_activat PF00158.26 EKE42914.1 - 6.6e-13 48.7 0.4 0.14 11.9 0.0 6.7 7 0 0 7 7 6 3 Sigma-54 interaction domain PduV-EutP PF10662.9 EKE42914.1 - 9.7e-13 48.1 6.3 0.013 15.2 0.0 6.6 6 0 0 6 6 6 3 Ethanolamine utilisation - propanediol utilisation RuvB_N PF05496.12 EKE42914.1 - 2.9e-12 46.6 2.0 0.11 12.3 0.0 6.6 6 0 0 6 6 6 2 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EKE42914.1 - 7.8e-12 45.6 0.0 0.8 9.9 0.0 6.6 6 0 0 6 6 6 3 AAA domain RsgA_GTPase PF03193.16 EKE42914.1 - 8.5e-12 45.3 5.7 0.46 10.4 0.0 7.4 7 0 0 7 7 7 3 RsgA GTPase AAA_19 PF13245.6 EKE42914.1 - 1.9e-11 44.5 1.2 0.033 14.5 0.1 6.7 7 0 0 7 7 5 2 AAA domain Mg_chelatase PF01078.21 EKE42914.1 - 3.9e-11 42.7 3.4 0.52 9.7 0.1 8.4 9 0 0 9 9 9 2 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 EKE42914.1 - 1.2e-10 41.0 2.5 0.029 13.4 0.0 5.1 5 0 0 5 5 5 3 Type II/IV secretion system protein Zeta_toxin PF06414.12 EKE42914.1 - 1.5e-10 40.7 0.0 0.63 9.3 0.0 6.2 6 0 0 6 6 6 2 Zeta toxin NACHT PF05729.12 EKE42914.1 - 2.2e-10 40.7 4.6 0.13 12.1 0.0 7.1 7 0 0 7 7 7 2 NACHT domain AAA_25 PF13481.6 EKE42914.1 - 2.7e-10 40.2 0.0 0.22 11.1 0.0 6.4 7 0 0 7 7 7 2 AAA domain AAA_28 PF13521.6 EKE42914.1 - 1.8e-09 38.0 1.2 0.98 9.6 0.0 6.7 6 0 0 6 6 6 1 AAA domain AAA_29 PF13555.6 EKE42914.1 - 3.9e-09 36.1 0.5 0.43 10.4 0.0 6.2 6 0 0 6 6 6 1 P-loop containing region of AAA domain DUF815 PF05673.13 EKE42914.1 - 4.9e-09 35.7 0.8 0.064 12.4 0.0 6.2 7 0 0 7 7 6 1 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.6 EKE42914.1 - 5.1e-09 36.4 0.5 0.28 11.3 0.0 6.0 5 0 0 5 5 5 2 Sigma-54 interaction domain Roc PF08477.13 EKE42914.1 - 1.1e-08 35.3 2.7 3.4 7.9 0.0 6.9 6 0 0 6 6 6 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EKE42914.1 - 3.6e-08 33.5 0.3 3.7 7.7 0.0 6.9 6 0 0 6 6 6 0 50S ribosome-binding GTPase Rad17 PF03215.15 EKE42914.1 - 9.6e-08 32.2 20.9 0.33 10.9 0.1 8.5 8 1 0 8 8 7 2 Rad17 P-loop domain Viral_helicase1 PF01443.18 EKE42914.1 - 1e-07 31.9 0.2 3.8 7.2 0.0 6.2 6 1 1 7 7 6 0 Viral (Superfamily 1) RNA helicase MCM PF00493.23 EKE42914.1 - 2e-07 30.4 1.9 0.1 11.6 0.0 6.4 7 0 0 7 7 7 2 MCM P-loop domain SRP54 PF00448.22 EKE42914.1 - 6.9e-07 29.1 4.0 0.057 13.0 0.0 4.7 5 0 0 5 5 4 1 SRP54-type protein, GTPase domain TniB PF05621.11 EKE42914.1 - 1.1e-06 28.2 2.3 4.2 6.7 0.0 6.4 6 0 0 6 6 6 0 Bacterial TniB protein IstB_IS21 PF01695.17 EKE42914.1 - 4e-06 26.7 0.3 22 4.7 0.0 5.8 6 0 0 6 6 5 0 IstB-like ATP binding protein PRK PF00485.18 EKE42914.1 - 1.1e-05 25.3 0.0 0.68 9.6 0.0 5.5 6 0 0 6 6 4 1 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.15 EKE42914.1 - 1.3e-05 25.2 9.5 1.7 8.5 0.0 6.9 6 1 0 6 6 6 2 NTPase ATP-synt_ab PF00006.25 EKE42914.1 - 7.2e-05 22.5 0.0 3.5 7.2 0.0 5.0 4 1 0 4 4 4 1 ATP synthase alpha/beta family, nucleotide-binding domain DEAD PF00270.29 EKE42914.1 - 0.00013 21.8 0.2 1.6 8.4 0.1 5.0 5 0 0 5 5 4 1 DEAD/DEAH box helicase CbiA PF01656.23 EKE42914.1 - 0.00013 22.1 1.6 6.2 6.9 0.0 6.0 7 0 0 7 7 5 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_8 PF12780.7 EKE42914.1 - 0.00029 20.3 18.5 0.0087 15.4 0.1 7.6 8 0 0 8 8 8 1 P-loop containing dynein motor region D4 CPT PF07931.12 EKE42914.1 - 0.001 19.0 1.9 19 5.1 0.0 5.9 7 0 0 7 7 5 0 Chloramphenicol phosphotransferase-like protein MobB PF03205.14 EKE42914.1 - 0.0021 17.9 4.5 5 7.0 0.0 5.3 5 0 0 5 5 5 0 Molybdopterin guanine dinucleotide synthesis protein B Cytidylate_kin PF02224.18 EKE42914.1 - 0.0087 15.8 0.0 26 4.4 0.0 4.8 5 0 0 5 5 5 0 Cytidylate kinase ATP_bind_1 PF03029.17 EKE42914.1 - 0.095 12.5 11.7 6.7 6.4 0.0 5.9 6 0 0 6 6 5 0 Conserved hypothetical ATP binding protein AAA_11 PF13086.6 EKE42915.1 - 8e-16 58.6 3.7 8e-16 58.6 3.7 2.0 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 EKE42915.1 - 7.3e-06 26.4 10.0 7.5e-05 23.1 5.5 3.1 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EKE42915.1 - 1.7e-05 24.7 0.1 0.0067 16.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 EKE42915.1 - 0.00014 21.2 1.1 0.015 14.6 0.3 2.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 EKE42915.1 - 0.00017 21.2 0.4 0.00041 19.9 0.4 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region PhoH PF02562.16 EKE42915.1 - 0.00078 19.0 3.2 0.011 15.2 0.8 3.0 3 0 0 3 3 3 1 PhoH-like protein Helicase_RecD PF05127.14 EKE42915.1 - 0.00096 19.0 2.7 0.084 12.7 0.1 2.9 3 0 0 3 3 3 1 Helicase CbiA PF01656.23 EKE42915.1 - 0.0028 17.7 0.1 0.0028 17.7 0.1 2.4 3 0 0 3 3 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_5 PF07728.14 EKE42915.1 - 0.003 17.5 0.1 0.0099 15.9 0.1 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) DEAD PF00270.29 EKE42915.1 - 0.005 16.6 4.5 0.17 11.6 0.6 2.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Thymidylate_kin PF02223.17 EKE42915.1 - 0.016 14.9 3.3 0.64 9.7 0.4 2.7 2 0 0 2 2 2 0 Thymidylate kinase NACHT PF05729.12 EKE42915.1 - 0.021 14.7 0.2 0.051 13.5 0.2 1.6 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 EKE42915.1 - 0.18 12.2 0.1 0.18 12.2 0.1 3.2 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EKE42915.1 - 0.21 11.8 0.1 0.21 11.8 0.1 4.0 4 1 1 5 5 5 0 AAA domain AAA_31 PF13614.6 EKE42915.1 - 0.26 11.2 21.2 0.046 13.6 10.8 3.7 2 1 1 3 3 3 0 AAA domain ResIII PF04851.15 EKE42915.1 - 0.65 10.0 20.1 0.013 15.5 8.3 3.7 3 1 1 4 4 3 0 Type III restriction enzyme, res subunit PI-PLC-X PF00388.19 EKE42915.1 - 3.8 7.1 8.1 0.28 10.8 0.3 2.9 3 1 0 3 3 3 0 Phosphatidylinositol-specific phospholipase C, X domain AAA_14 PF13173.6 EKE42915.1 - 5.3 7.1 10.8 0.1 12.6 0.4 3.2 3 0 0 3 3 3 0 AAA domain HAUS6_N PF14661.6 EKE42917.1 - 0.19 11.3 9.3 0.19 11.3 9.3 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus HSF_DNA-bind PF00447.17 EKE42918.1 - 6e-26 90.9 0.4 6e-26 90.9 0.4 1.6 2 0 0 2 2 2 1 HSF-type DNA-binding SlyX PF04102.12 EKE42918.1 - 0.00012 22.6 3.6 0.00024 21.7 3.6 1.5 1 0 0 1 1 1 1 SlyX Cnn_1N PF07989.11 EKE42918.1 - 0.0018 18.4 1.1 0.0018 18.4 1.1 2.3 1 1 1 2 2 2 1 Centrosomin N-terminal motif 1 JIP_LZII PF16471.5 EKE42918.1 - 0.0065 16.6 3.9 0.013 15.7 3.9 1.5 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II DUF4460 PF14687.6 EKE42918.1 - 0.018 15.1 0.3 0.036 14.1 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4460) V_ATPase_I PF01496.19 EKE42918.1 - 0.053 11.5 1.4 0.072 11.0 1.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF349 PF03993.12 EKE42918.1 - 0.063 13.6 2.0 0.12 12.7 2.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) DUF3450 PF11932.8 EKE42918.1 - 0.49 9.7 6.0 0.67 9.2 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) LSM PF01423.22 EKE42919.1 - 3.9e-14 52.1 0.1 4.5e-14 51.9 0.1 1.0 1 0 0 1 1 1 1 LSM domain DUF2362 PF10154.9 EKE42920.1 - 0.0027 16.7 2.7 0.012 14.6 0.8 2.1 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2362) DUF4477 PF14780.6 EKE42921.1 - 0.00043 20.0 0.7 0.00043 20.0 0.7 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4477) GGDEF PF00990.21 EKE42921.1 - 0.031 14.0 0.5 0.082 12.7 0.2 1.9 1 1 1 2 2 2 0 Diguanylate cyclase, GGDEF domain EF-hand_4 PF12763.7 EKE42922.1 - 0.0057 16.6 1.8 0.39 10.7 0.0 3.2 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand WD40 PF00400.32 EKE42923.1 - 0.00029 21.6 7.0 0.007 17.2 0.0 4.6 6 0 0 6 6 6 1 WD domain, G-beta repeat zf-RING_14 PF17978.1 EKE42923.1 - 0.3 11.5 2.0 2.7 8.5 2.0 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Synaptobrevin PF00957.21 EKE42924.1 - 2.3e-14 53.0 0.1 2.3e-14 53.0 0.1 1.7 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.6 EKE42924.1 - 4.1e-06 26.7 0.1 8.4e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Sec20 PF03908.13 EKE42924.1 - 0.0095 15.8 0.5 0.024 14.5 0.5 1.7 1 0 0 1 1 1 1 Sec20 DUF4713 PF15831.5 EKE42924.1 - 0.041 14.3 3.2 0.098 13.1 3.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Muted PF14942.6 EKE42924.1 - 0.065 13.6 2.7 0.055 13.8 1.2 1.7 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein Pkinase_Tyr PF07714.17 EKE42926.1 - 1e-23 84.0 0.0 1.2e-23 83.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE42926.1 - 2.9e-20 72.8 0.1 4.9e-20 72.0 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 EKE42926.1 - 0.016 14.8 0.2 0.036 13.7 0.2 1.5 1 1 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 EKE42926.1 - 0.023 14.0 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like cEGF PF12662.7 EKE42927.1 - 0.00013 21.8 6.0 0.021 14.7 1.5 2.9 2 0 0 2 2 2 2 Complement Clr-like EGF-like DUF4215 PF13948.6 EKE42927.1 - 2.7 8.5 13.2 10 6.6 5.5 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4215) FXa_inhibition PF14670.6 EKE42927.1 - 3.6 7.9 14.8 0.67 10.3 3.9 2.9 2 1 1 3 3 3 0 Coagulation Factor Xa inhibitory site zf-3CxxC_2 PF17180.4 EKE42928.1 - 0.0086 16.8 1.2 0.039 14.7 1.2 2.1 1 1 0 1 1 1 1 Zinc-binding domain zf_UBZ PF18439.1 EKE42928.1 - 0.63 9.7 2.9 3 7.5 0.4 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger eIF2A PF08662.11 EKE42929.1 - 1e-40 139.7 0.1 4.8e-39 134.3 0.0 2.8 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EKE42929.1 - 0.074 13.9 0.6 40 5.3 0.0 3.9 5 0 0 5 5 5 0 WD domain, G-beta repeat PNP_UDP_1 PF01048.20 EKE42930.1 - 7.1e-28 97.4 0.0 9.7e-28 97.0 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily COMM_domain PF07258.14 EKE42931.1 - 0.0012 19.0 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 COMM domain Guanylate_kin PF00625.21 EKE42931.1 - 0.019 14.6 3.2 0.097 12.4 0.5 2.4 1 1 0 2 2 2 0 Guanylate kinase PhaP_Bmeg PF09602.10 EKE42931.1 - 0.4 10.6 4.3 0.39 10.6 1.0 2.0 1 1 1 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DEAD PF00270.29 EKE42932.1 - 1.1e-41 142.6 0.3 1.6e-41 142.0 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EKE42932.1 - 2.9e-31 108.1 0.3 1.4e-29 102.7 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EKE42932.1 - 0.0011 19.0 0.1 0.0019 18.2 0.1 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EKE42932.1 - 0.0058 16.0 1.4 0.02 14.3 0.1 2.0 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 EKE42932.1 - 0.024 14.5 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Helicase AAA_30 PF13604.6 EKE42932.1 - 0.12 12.1 0.3 0.21 11.3 0.3 1.4 1 1 0 1 1 1 0 AAA domain PQQ_2 PF13360.6 EKE42933.1 - 1.6e-05 24.6 0.0 0.012 15.2 0.0 3.1 2 1 0 2 2 2 2 PQQ-like domain PQQ_3 PF13570.6 EKE42933.1 - 1.6e-05 25.2 0.1 0.076 13.5 0.0 3.6 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 EKE42933.1 - 0.00047 19.9 7.7 0.21 11.6 0.2 4.6 5 0 0 5 5 5 2 PQQ enzyme repeat VCBS PF13517.6 EKE42933.1 - 0.081 13.5 0.4 13 6.5 0.1 3.5 3 1 1 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella UCH PF00443.29 EKE42934.1 - 4.3e-32 111.6 1.4 4.3e-32 111.6 1.4 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 EKE42934.1 - 6.9e-18 64.2 0.1 5.7e-08 32.5 0.1 2.6 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP PF02148.19 EKE42934.1 - 1.8e-17 63.4 7.1 1.4e-13 51.0 0.0 3.3 3 0 0 3 3 3 2 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 EKE42934.1 - 4.4e-10 39.2 4.5 7.5e-09 35.2 1.7 2.6 2 0 0 2 2 2 1 Variant UBP zinc finger UCH_1 PF13423.6 EKE42934.1 - 8.6e-08 32.1 3.5 3.6e-07 30.1 3.5 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.6 EKE42934.1 - 0.00037 20.3 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 2 UBA-like domain CUE PF02845.16 EKE42934.1 - 0.007 16.1 0.0 1.2 9.0 0.0 2.4 2 0 0 2 2 2 1 CUE domain HOIP-UBA PF16678.5 EKE42934.1 - 0.017 15.1 2.0 1.7 8.7 0.1 2.5 1 1 1 2 2 2 0 HOIP UBA domain pair zf-B_box PF00643.24 EKE42934.1 - 3.2 8.0 10.6 0.34 11.1 5.7 1.9 2 0 0 2 2 2 0 B-box zinc finger SMC_N PF02463.19 EKE42936.1 - 3.8e-43 147.5 86.1 5.5e-33 114.2 0.4 4.9 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EKE42936.1 - 5.9e-26 91.1 0.1 4.3e-25 88.3 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EKE42936.1 - 2.2e-15 57.7 15.8 2.2e-15 57.7 15.8 9.2 1 1 8 9 9 9 1 AAA domain AAA_21 PF13304.6 EKE42936.1 - 6.7e-11 42.5 8.8 7.8e-07 29.2 0.7 5.3 2 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EKE42936.1 - 9.8e-11 42.0 17.3 9.8e-11 42.0 17.3 5.0 1 1 3 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 EKE42936.1 - 4.7e-05 23.1 0.0 9.4e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Ribosomal_L27e PF01777.18 EKE42937.1 - 0.14 12.5 0.3 0.14 12.5 0.3 2.7 2 0 0 2 2 2 0 Ribosomal L27e protein family FRB_dom PF08771.11 EKE42939.1 - 0.2 12.1 0.0 0.2 12.1 0.0 5.9 6 3 1 7 7 7 0 FKBP12-rapamycin binding domain zf-CCHC_2 PF13696.6 EKE42940.1 - 7.2e-10 38.5 10.5 7.2e-10 38.5 10.5 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-C3HC4_3 PF13920.6 EKE42940.1 - 0.0072 16.2 13.8 0.0072 16.2 13.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC PF00098.23 EKE42940.1 - 0.017 15.2 3.9 0.017 15.2 3.9 2.9 3 0 0 3 3 3 0 Zinc knuckle zf-RING_5 PF14634.6 EKE42940.1 - 0.018 15.0 16.8 0.018 15.0 16.8 2.4 2 0 0 2 2 2 0 zinc-RING finger domain Rimk_N PF18030.1 EKE42940.1 - 0.088 13.2 0.7 0.65 10.4 0.1 2.3 2 0 0 2 2 2 0 RimK PreATP-grasp domain DUF2766 PF10964.8 EKE42940.1 - 0.092 12.7 0.3 11 6.1 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2766) zf-RING_6 PF14835.6 EKE42940.1 - 0.5 10.3 6.4 1.1 9.1 6.4 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zinc-ribbons_6 PF07191.12 EKE42940.1 - 7.2 6.7 19.0 34 4.5 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbons PP2C PF00481.21 EKE42941.1 - 2.8e-32 112.4 0.0 3.6e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EKE42941.1 - 7.3e-06 25.8 0.0 2.5e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EKE42941.1 - 0.057 13.3 0.0 3 7.7 0.0 2.1 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Importin_rep_5 PF18816.1 EKE42941.1 - 0.15 12.4 0.0 0.68 10.3 0.0 2.2 2 0 0 2 2 2 0 Importin repeat PrmA PF06325.13 EKE42942.1 - 3.7e-08 33.1 0.0 5.2e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EKE42942.1 - 9.6e-08 32.6 0.0 2.2e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EKE42942.1 - 1.5e-07 32.0 0.0 6.9e-07 29.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EKE42942.1 - 1.5e-05 24.9 0.0 2.5e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EKE42942.1 - 3e-05 23.6 0.1 4.7e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EKE42942.1 - 8e-05 22.6 0.1 0.00013 22.0 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EKE42942.1 - 0.00042 20.1 0.1 0.00076 19.3 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.6 EKE42942.1 - 0.00048 20.0 0.0 0.00083 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EKE42942.1 - 0.0016 17.9 0.5 0.0041 16.6 0.2 2.0 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_9 PF08003.11 EKE42942.1 - 0.0016 17.4 0.0 0.0022 17.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EKE42942.1 - 0.022 14.1 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 EKE42942.1 - 0.025 14.3 0.1 0.041 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 EKE42942.1 - 0.068 14.2 0.0 0.16 13.0 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 EKE42942.1 - 0.075 12.1 0.0 3.1 6.8 0.0 2.1 2 0 0 2 2 2 0 DREV methyltransferase Cons_hypoth95 PF03602.15 EKE42942.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Anillin PF08174.11 EKE42942.1 - 0.12 12.8 0.1 0.24 11.8 0.1 1.4 1 0 0 1 1 1 0 Cell division protein anillin Methyltransf_32 PF13679.6 EKE42942.1 - 0.19 11.7 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CH PF00307.31 EKE42943.1 - 7.8e-28 96.8 1.4 3.1e-13 49.9 0.3 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EKE42943.1 - 0.025 14.4 0.0 0.22 11.4 0.0 2.4 2 2 0 2 2 2 0 CAMSAP CH domain H_kinase_N PF12282.8 EKE42943.1 - 0.097 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Signal transduction histidine kinase Pkinase PF00069.25 EKE42944.1 - 1.2e-27 97.0 0.2 1.9e-27 96.3 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE42944.1 - 2.3e-13 50.1 0.0 4.1e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE42944.1 - 4e-06 26.4 0.0 7.8e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EKE42944.1 - 0.0024 17.3 0.4 0.0049 16.2 0.4 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EKE42944.1 - 0.0032 17.4 0.0 0.0051 16.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EKE42944.1 - 0.028 13.2 0.0 0.055 12.2 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase E1-E2_ATPase PF00122.20 EKE42945.1 - 1.5e-25 89.8 0.2 3.8e-25 88.5 0.2 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EKE42945.1 - 2.2e-18 67.3 0.0 2.8e-11 44.1 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EKE42945.1 - 1.1e-08 35.1 0.1 4.6e-08 33.1 0.0 2.1 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EKE42945.1 - 1.7e-05 24.7 5.2 0.02 14.6 0.1 2.7 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EKE42945.1 - 0.0042 16.7 0.0 0.061 13.0 0.0 2.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus DUF2529 PF10740.9 EKE42945.1 - 0.039 13.6 1.2 8.5 6.0 0.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF2529) MMPL PF03176.15 EKE42946.1 - 4e-63 213.4 7.4 5.7e-32 111.0 1.3 2.3 2 0 0 2 2 2 2 MMPL family Ank_2 PF12796.7 EKE42947.1 - 4.6e-13 49.6 0.1 2.9e-05 24.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EKE42947.1 - 5.1e-13 49.3 0.1 3.7e-05 24.2 0.0 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EKE42947.1 - 7.2e-10 38.3 0.1 0.0023 18.3 0.0 4.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EKE42947.1 - 5.5e-09 36.1 0.1 3.1e-05 24.2 0.0 3.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EKE42947.1 - 1.9e-06 28.0 0.5 6.9e-05 23.1 0.1 2.9 2 0 0 2 2 2 1 Ankyrin repeat Patatin PF01734.22 EKE42947.1 - 1.2e-05 25.6 0.0 5.8e-05 23.4 0.0 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase VPS13_C PF16909.5 EKE42948.1 - 6.2e-32 110.8 11.4 8e-27 94.2 2.7 3.0 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EKE42948.1 - 9e-30 103.2 0.8 6.6e-29 100.4 0.8 2.7 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 EKE42948.1 - 6.3e-23 81.8 6.9 2.4e-21 76.6 3.2 2.7 2 0 0 2 2 2 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 EKE42948.1 - 1.4e-10 41.0 24.7 9.7e-10 38.3 0.0 5.7 5 2 1 6 6 6 2 Repeating coiled region of VPS13 ATG_C PF09333.11 EKE42948.1 - 9.6e-07 29.1 0.0 4.2e-06 27.0 0.0 2.1 1 1 1 2 2 2 1 Autophagy-related protein C terminal domain ADH_N PF08240.12 EKE42949.1 - 0.12 12.2 0.5 0.25 11.2 0.1 1.6 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-like domain TLD PF07534.16 EKE42950.1 - 2e-10 41.0 0.4 6.8e-10 39.3 0.4 1.9 1 0 0 1 1 1 1 TLD Telomere_reg-2 PF10193.9 EKE42950.1 - 0.072 13.5 4.5 0.13 12.8 3.0 2.1 1 1 1 2 2 2 0 Telomere length regulation protein ZYG-11_interact PF05884.12 EKE42950.1 - 0.28 10.5 8.2 1.1 8.6 0.1 2.2 2 0 0 2 2 2 0 Interactor of ZYG-11 BTB PF00651.31 EKE42951.1 - 5e-08 33.2 1.1 6.2e-06 26.4 0.0 3.4 2 1 1 3 3 3 1 BTB/POZ domain PRP21_like_P PF12230.8 EKE42951.1 - 0.0067 16.3 0.3 0.0067 16.3 0.3 2.5 2 1 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein zf_UBZ PF18439.1 EKE42951.1 - 0.037 13.6 0.2 0.073 12.7 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-ACC PF17848.1 EKE42951.1 - 0.096 12.8 0.1 0.33 11.1 0.1 2.0 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain zf-WRNIP1_ubi PF18279.1 EKE42951.1 - 0.099 13.3 2.4 0.27 12.0 2.4 1.7 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain COG2 PF06148.11 EKE42951.1 - 0.11 12.5 1.9 0.16 12.1 0.1 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4126 PF13548.6 EKE42951.1 - 0.21 11.3 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4126) HAUS5 PF14817.6 EKE42952.1 - 0.23 10.2 2.4 0.33 9.6 2.4 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 E2F_CC-MB PF16421.5 EKE42952.1 - 3.8 7.9 10.2 21 5.5 0.0 3.7 3 1 1 4 4 4 0 E2F transcription factor CC-MB domain ubiquitin PF00240.23 EKE42953.1 - 9.9e-23 79.7 0.2 1.1e-22 79.6 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EKE42953.1 - 3.8e-10 39.5 0.1 4e-10 39.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EKE42953.1 - 2.4e-06 27.9 0.0 1.5e-05 25.4 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EKE42953.1 - 0.019 14.9 0.0 0.022 14.7 0.0 1.1 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EKE42953.1 - 0.069 13.5 0.1 0.12 12.7 0.1 1.5 1 1 1 2 2 2 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EKE42953.1 - 0.12 12.5 0.0 0.28 11.3 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like SH3_9 PF14604.6 EKE42955.1 - 1.5e-14 53.5 1.1 2.6e-14 52.8 1.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EKE42955.1 - 8.1e-14 51.1 0.2 1.4e-13 50.3 0.2 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EKE42955.1 - 1.6e-11 43.6 1.0 3.1e-11 42.7 1.0 1.5 1 0 0 1 1 1 1 SH3 domain Arfaptin PF06456.13 EKE42955.1 - 4.1e-05 23.3 5.1 0.00024 20.8 1.6 2.3 2 0 0 2 2 2 2 Arfaptin-like domain BAR PF03114.18 EKE42955.1 - 0.0025 17.5 10.5 0.0025 17.5 4.8 2.6 1 1 1 2 2 2 1 BAR domain RRM_1 PF00076.22 EKE42956.1 - 5.9e-16 58.1 0.0 1.1e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EKE42956.1 - 0.017 15.2 0.2 0.039 14.0 0.0 1.8 2 0 0 2 2 2 0 Limkain b1 Cadherin_C_2 PF16492.5 EKE42957.1 - 0.00011 22.8 0.1 0.0003 21.5 0.0 1.7 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Shisa PF13908.6 EKE42957.1 - 0.00057 20.2 7.7 0.00057 20.2 7.7 1.4 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 EKE42957.1 - 0.0054 17.6 0.8 0.2 12.5 0.3 2.2 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Claudin_2 PF13903.6 EKE42957.1 - 0.39 10.4 4.0 0.59 9.8 3.7 1.3 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Tam41_Mmp37 PF09139.11 EKE42957.1 - 1.6 8.1 4.8 2.3 7.6 4.8 1.1 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial Comm PF15957.5 EKE42957.1 - 2.9 8.2 6.9 0.17 12.3 0.6 2.0 2 1 0 2 2 2 0 Commissureless LRR_4 PF12799.7 EKE42958.1 - 2.8e-07 30.7 17.5 0.00015 22.0 0.4 4.0 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EKE42958.1 - 1.1e-06 28.3 11.6 0.0042 16.8 0.4 3.0 1 1 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 EKE42958.1 - 0.64 10.8 9.0 6.4 7.7 0.1 4.8 4 0 0 4 4 4 0 Leucine Rich Repeat Glyco_hydro38C2 PF17677.1 EKE42959.1 - 0.078 13.1 1.0 0.22 11.6 0.6 2.0 2 0 0 2 2 2 0 Glycosyl hydrolases family 38 C-terminal beta sandwich domain RIX1 PF08167.12 EKE42959.1 - 0.21 11.3 12.1 2.1 8.1 0.1 5.0 6 1 0 6 6 6 0 rRNA processing/ribosome biogenesis BRCT_3 PF18428.1 EKE42959.1 - 0.4 10.8 4.3 8.3 6.6 0.1 2.9 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain Ins134_P3_kin PF05770.11 EKE42960.1 - 1.3e-30 106.5 0.4 2.6e-30 105.4 0.4 1.5 1 1 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain ATP-grasp_3 PF02655.14 EKE42960.1 - 2.8e-05 24.2 0.6 0.00015 21.9 0.2 2.2 2 1 0 2 2 2 1 ATP-grasp domain TTL PF03133.15 EKE42960.1 - 0.00089 18.5 2.3 0.019 14.1 0.1 2.3 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family Ins134_P3_kin_N PF17927.1 EKE42960.1 - 0.094 13.1 0.1 1.6 9.2 0.0 2.8 2 1 1 3 3 3 0 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain UME PF08064.13 EKE42961.1 - 0.091 12.7 0.4 0.21 11.5 0.1 1.7 2 0 0 2 2 2 0 UME (NUC010) domain DUF4200 PF13863.6 EKE42962.1 - 0.0046 17.4 29.6 0.027 14.9 15.3 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4200) DUF1043 PF06295.12 EKE42962.1 - 1.4 9.0 9.4 1 9.4 4.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) AKNA PF12443.8 EKE42962.1 - 2.6 8.8 8.4 0.26 12.0 1.2 2.4 2 1 0 2 2 2 0 AT-hook-containing transcription factor Aminopep PF10023.9 EKE42962.1 - 2.9 7.2 8.2 1.9 7.8 5.8 1.8 1 1 1 2 2 2 0 Putative aminopeptidase DUF2203 PF09969.9 EKE42962.1 - 3.2 8.5 12.0 10 6.9 4.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Fib_alpha PF08702.10 EKE42962.1 - 4.2 7.5 18.9 4.4 7.5 8.7 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family GTP-bdg_M PF16360.5 EKE42962.1 - 6.3 7.5 8.3 21 5.8 1.3 2.8 2 1 0 2 2 2 0 GTP-binding GTPase Middle Region CENP-K PF11802.8 EKE42962.1 - 6.5 6.2 25.8 0.12 12.0 11.3 2.1 1 1 1 2 2 2 0 Centromere-associated protein K RecG_N PF17190.4 EKE42962.1 - 6.9 7.5 17.2 7.2 7.4 0.1 4.2 3 1 1 4 4 4 0 RecG N-terminal helical domain HMG_box PF00505.19 EKE42963.1 - 9.2e-07 29.2 2.7 1.9e-06 28.2 0.0 2.6 2 2 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EKE42963.1 - 1.1e-06 29.2 0.0 3.7e-06 27.4 0.0 1.9 1 0 0 1 1 1 1 HMG-box domain DUF1841 PF08897.11 EKE42963.1 - 0.12 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1841) Pkinase PF00069.25 EKE42964.1 - 2.8e-06 26.9 3.1 0.039 13.3 0.4 2.7 2 0 0 2 2 2 2 Protein kinase domain Kdo PF06293.14 EKE42964.1 - 0.0025 17.2 0.0 0.0052 16.2 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Enoyl_reductase PF12241.8 EKE42964.1 - 0.058 12.7 0.1 0.14 11.5 0.1 1.6 1 0 0 1 1 1 0 Trans-2-enoyl-CoA reductase catalytic region FHA PF00498.26 EKE42965.1 - 6.6e-05 23.2 7.2 0.00016 21.9 0.2 3.8 2 1 2 4 4 4 1 FHA domain KAR PF15222.6 EKE42965.1 - 0.039 14.3 0.0 0.094 13.0 0.0 1.7 1 0 0 1 1 1 0 Kidney androgen-regulated TIG PF01833.24 EKE42966.1 - 4.1e-09 36.4 0.9 7.5e-09 35.5 0.9 1.4 1 0 0 1 1 1 1 IPT/TIG domain ubiquitin PF00240.23 EKE42966.1 - 2.3e-06 27.3 0.1 2.2e-05 24.1 0.1 2.1 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 EKE42966.1 - 0.0099 15.7 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like LPMO_10 PF03067.15 EKE42966.1 - 0.072 13.7 0.0 0.081 13.6 0.0 1.1 1 0 0 1 1 1 0 Lytic polysaccharide mono-oxygenase, cellulose-degrading Ubiquitin_5 PF18037.1 EKE42966.1 - 0.11 12.9 0.1 0.18 12.1 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain zf-C3HC4 PF00097.25 EKE42967.1 - 0.0043 16.9 4.6 0.032 14.1 3.4 3.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EKE42967.1 - 0.13 12.6 9.2 0.034 14.4 2.3 3.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EKE42967.1 - 0.29 11.0 6.3 1.6 8.7 6.3 2.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 EKE42967.1 - 0.36 10.8 8.7 0.16 11.9 4.5 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 UvrB PF12344.8 EKE42967.1 - 0.62 10.0 4.3 3.1 7.7 1.8 2.8 2 0 0 2 2 2 0 Ultra-violet resistance protein B zf-C3H2C3 PF17122.5 EKE42967.1 - 2 8.5 7.5 4.7 7.3 7.5 1.7 1 0 0 1 1 1 0 Zinc-finger zf-RING_UBOX PF13445.6 EKE42967.1 - 2.8 8.0 8.2 14 5.8 8.2 2.3 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 EKE42967.1 - 9.2 6.3 14.5 1.2 9.2 8.8 2.7 2 0 0 2 2 2 0 zinc-RING finger domain Peptidase_C1 PF00112.23 EKE42968.1 - 6e-11 42.9 4.9 4.5e-10 40.0 4.9 1.9 1 1 0 1 1 1 1 Papain family cysteine protease Tetraspanin PF00335.20 EKE42969.1 - 0.013 15.2 19.1 0.13 12.0 19.6 2.1 1 1 0 1 1 1 0 Tetraspanin family FtsL PF04999.13 EKE42969.1 - 0.24 11.4 0.7 4.9 7.2 0.1 2.6 3 0 0 3 3 3 0 Cell division protein FtsL DUF3671 PF12420.8 EKE42969.1 - 0.45 10.6 2.8 1.3 9.1 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function DUF1129 PF06570.11 EKE42969.1 - 1.7 8.1 7.2 1.5 8.3 4.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) OST3_OST6 PF04756.13 EKE42969.1 - 2.3 7.5 7.2 1.6 8.0 2.4 2.1 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family Pmp3 PF01679.17 EKE42970.1 - 1.4e-13 50.8 4.1 1.9e-13 50.4 4.1 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Trep_Strep PF09605.10 EKE42970.1 - 0.0075 16.3 4.5 0.0086 16.1 4.5 1.1 1 0 0 1 1 1 1 Hypothetical bacterial integral membrane protein (Trep_Strep) AI-2E_transport PF01594.16 EKE42970.1 - 0.027 13.6 2.4 0.027 13.6 2.4 1.0 1 0 0 1 1 1 0 AI-2E family transporter DUF3671 PF12420.8 EKE42970.1 - 1.3 9.1 5.0 0.56 10.3 1.1 1.9 1 1 1 2 2 2 0 Protein of unknown function Synaptobrevin PF00957.21 EKE42971.1 - 1.1e-21 76.4 0.2 1.7e-21 75.8 0.2 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EKE42971.1 - 3.7e-06 26.9 0.0 8.5e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 Regulated-SNARE-like domain Sec20 PF03908.13 EKE42971.1 - 0.00091 19.1 0.1 0.0019 18.0 0.1 1.5 1 0 0 1 1 1 1 Sec20 Spore_III_AB PF09548.10 EKE42971.1 - 0.0035 17.5 0.0 0.0048 17.0 0.0 1.2 1 0 0 1 1 1 1 Stage III sporulation protein AB (spore_III_AB) DUF5345 PF17280.2 EKE42971.1 - 0.0063 16.5 0.1 1.2 9.1 0.0 2.4 3 0 0 3 3 3 2 Family of unknown function (DUF5345) ComC PF03047.14 EKE42971.1 - 0.018 14.8 1.8 0.053 13.3 1.8 1.9 1 0 0 1 1 1 0 COMC family DUF1542 PF07564.11 EKE42971.1 - 0.034 14.3 0.1 0.065 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) DUF2515 PF10720.9 EKE42972.1 - 0.021 14.0 4.0 0.021 14.0 2.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2515) TMEM239 PF15841.5 EKE42973.1 - 0.54 10.1 3.7 0.17 11.8 0.5 1.7 2 0 0 2 2 2 0 Transmembrane protein 239 family RNA_pol_Rpb2_6 PF00562.28 EKE42974.1 - 1.6e-121 406.1 1.2 2e-121 405.8 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EKE42974.1 - 4.8e-37 127.4 0.5 8.3e-37 126.7 0.5 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EKE42974.1 - 6.3e-33 113.0 0.3 2.8e-32 111.0 0.3 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EKE42974.1 - 5.4e-23 81.0 0.0 1.2e-22 79.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 EKE42974.1 - 6e-22 78.2 0.3 1.1e-21 77.3 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_5 PF04567.17 EKE42974.1 - 5.7e-19 68.4 0.1 2.7e-18 66.2 0.1 2.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.13 EKE42974.1 - 7.3e-17 61.4 0.0 2e-16 60.0 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 Endotoxin_N PF03945.14 EKE42974.1 - 0.054 13.2 0.2 0.15 11.8 0.2 1.7 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain JHY PF15261.6 EKE42974.1 - 0.21 12.3 1.2 0.86 10.3 0.2 2.3 1 1 1 2 2 2 0 Jhy protein Ku_PK_bind PF08785.11 EKE42974.1 - 0.22 11.7 2.7 20 5.3 0.1 3.4 3 0 0 3 3 3 0 Ku C terminal domain like Siah-Interact_N PF09032.11 EKE42974.1 - 0.37 11.1 3.7 4.3 7.7 0.2 3.0 3 0 0 3 3 3 0 Siah interacting protein, N terminal SWIRM PF04433.17 EKE42975.1 - 4.1e-22 78.3 0.3 2.1e-21 76.0 0.2 2.2 2 0 0 2 2 2 1 SWIRM domain UPF0154 PF03672.13 EKE42976.1 - 0.22 11.5 1.0 0.45 10.6 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) Ribosomal_L29 PF00831.23 EKE42977.1 - 2.8e-16 59.2 1.2 2.8e-16 59.2 1.2 2.3 2 0 0 2 2 2 1 Ribosomal L29 protein ESM4 PF15952.5 EKE42977.1 - 0.082 13.3 1.7 0.1 13.0 1.7 1.2 1 0 0 1 1 1 0 Enhancer of split M4 family DUF4917 PF16263.5 EKE42977.1 - 0.083 12.2 0.1 0.1 11.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4917) L27 PF02828.16 EKE42977.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.7 2 0 0 2 2 2 0 L27 domain Herpes_VP19C PF03327.14 EKE42978.1 - 0.07 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus capsid shell protein VP19C Yeast-kill-tox PF09207.11 EKE42979.1 - 0.039 14.6 0.1 0.069 13.8 0.1 1.4 1 0 0 1 1 1 0 Yeast killer toxin Peptidase_C1 PF00112.23 EKE42980.1 - 9.9e-25 87.9 6.2 1.8e-24 87.1 6.2 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE42980.1 - 3.2e-09 37.1 1.3 8.6e-09 35.7 1.3 1.8 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Sugar_tr PF00083.24 EKE42982.1 - 2.2e-39 135.6 31.5 6.4e-21 74.7 10.3 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EKE42982.1 - 2.1e-32 112.4 31.2 1.5e-29 103.0 22.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EKE42982.1 - 9.1e-06 25.2 1.7 9.1e-06 25.2 1.7 2.0 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.6 EKE42982.1 - 0.00015 20.4 31.1 0.0014 17.3 8.5 3.5 2 2 1 3 3 3 3 MFS/sugar transport protein DUF4492 PF14899.6 EKE42982.1 - 0.32 11.0 5.0 0.17 11.8 1.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4492) RhoGAP PF00620.27 EKE42983.1 - 2.1e-20 73.1 0.3 2.6e-19 69.5 0.3 2.9 1 1 0 1 1 1 1 RhoGAP domain RhoGEF PF00621.20 EKE42983.1 - 3.7e-12 46.9 4.9 3.7e-12 46.9 4.9 3.3 3 0 0 3 3 3 2 RhoGEF domain APG6_N PF17675.1 EKE42983.1 - 0.035 14.6 0.8 0.035 14.6 0.8 3.8 4 1 0 4 4 4 0 Apg6 coiled-coil region Mvb12 PF09452.10 EKE42983.1 - 0.79 10.2 4.3 1.7 9.2 0.3 3.7 4 1 1 5 5 5 0 ESCRT-I subunit Mvb12 PriX PF18689.1 EKE42983.1 - 1.5 9.2 8.3 3.2 8.2 0.2 3.6 3 0 0 3 3 3 0 Primase X DUF2968 PF11180.8 EKE42983.1 - 1.6 8.3 9.1 0.25 11.0 4.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) Syntaxin-6_N PF09177.11 EKE42983.1 - 2.1 9.0 8.8 3.7 8.2 5.7 3.2 2 0 0 2 2 2 0 Syntaxin 6, N-terminal RhoGEF PF00621.20 EKE42984.1 - 2.3e-05 24.7 0.4 2.3e-05 24.7 0.4 2.1 2 1 0 2 2 2 1 RhoGEF domain ABC_tran PF00005.27 EKE42985.1 - 3.3e-29 102.1 0.0 1.1e-28 100.5 0.0 1.9 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EKE42985.1 - 1.1e-13 51.1 28.1 1.1e-13 51.1 28.1 1.7 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EKE42985.1 - 1.2e-08 35.2 0.0 0.00059 19.7 0.0 2.8 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EKE42985.1 - 0.00086 19.0 0.5 0.0063 16.2 0.1 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EKE42985.1 - 0.012 15.5 0.0 0.033 14.1 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase Med28 PF11594.8 EKE42985.1 - 0.03 14.4 0.0 0.087 12.9 0.0 1.7 1 0 0 1 1 1 0 Mediator complex subunit 28 AAA_23 PF13476.6 EKE42985.1 - 0.052 14.1 0.2 0.052 14.1 0.2 3.0 3 1 1 4 4 4 0 AAA domain AAA_30 PF13604.6 EKE42985.1 - 0.053 13.2 0.3 4.4 7.0 0.1 2.4 2 0 0 2 2 2 0 AAA domain MLANA PF14991.6 EKE42985.1 - 0.11 12.8 0.0 0.36 11.1 0.0 1.9 1 0 0 1 1 1 0 Protein melan-A MIR PF02815.19 EKE42985.1 - 0.73 9.7 4.2 19 5.1 0.0 2.7 3 0 0 3 3 3 0 MIR domain Adaptin_N PF01602.20 EKE42986.1 - 7.4e-73 245.9 21.4 7.4e-73 245.9 21.4 1.4 2 0 0 2 2 2 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EKE42986.1 - 3.2e-18 66.3 0.6 1.2e-17 64.4 0.6 2.1 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Cnd1 PF12717.7 EKE42986.1 - 2.3e-09 37.5 22.2 0.00013 22.1 2.6 4.8 2 2 3 5 5 5 4 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EKE42986.1 - 1.6e-07 31.6 0.1 0.0003 21.1 0.0 4.0 3 3 1 4 4 4 1 HEAT repeats HEAT PF02985.22 EKE42986.1 - 4.4e-06 26.5 1.5 0.32 11.4 0.0 4.9 5 0 0 5 5 5 1 HEAT repeat TFCD_C PF12612.8 EKE42986.1 - 0.007 16.2 0.4 1.1 9.1 0.0 3.2 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal Vac14_Fab1_bd PF12755.7 EKE42986.1 - 2.2 8.9 9.8 15 6.2 0.1 5.1 3 2 2 5 5 5 0 Vacuolar 14 Fab1-binding region Ribosomal_S4 PF00163.19 EKE42987.1 - 0.0014 19.5 0.2 0.0019 19.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain RTBV_P46 PF06216.11 EKE42987.1 - 0.13 11.1 0.1 0.13 11.1 0.1 1.0 1 0 0 1 1 1 0 Rice tungro bacilliform virus P46 protein CENP-X PF09415.10 EKE42988.1 - 0.025 14.9 2.7 0.16 12.3 1.2 3.2 2 0 0 2 2 2 0 CENP-S associating Centromere protein X COP23 PF14218.6 EKE42988.1 - 0.028 14.2 0.0 0.081 12.7 0.0 1.8 1 0 0 1 1 1 0 Circadian oscillating protein COP23 Peptidase_M24 PF00557.24 EKE42989.1 - 1.1e-34 119.9 0.0 1.7e-34 119.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 EKE42989.1 - 2e-20 73.5 0.3 2.1e-19 70.2 0.1 2.3 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 EKE42989.1 - 5e-12 45.7 0.9 8.9e-12 44.9 0.1 1.9 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EKE42989.1 - 0.00012 22.8 0.0 0.00035 21.2 0.0 1.7 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain SSXRD PF09514.10 EKE42989.1 - 0.14 11.7 0.1 0.34 10.5 0.1 1.6 1 0 0 1 1 1 0 SSXRD motif HP0268 PF18618.1 EKE42990.1 - 0.019 15.4 1.9 0.038 14.4 1.9 1.5 1 0 0 1 1 1 0 HP0268 eIF-3c_N PF05470.12 EKE42991.1 - 3.9e-13 48.6 0.1 3.9e-13 48.6 0.1 2.8 2 1 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus ThiF PF00899.21 EKE42992.1 - 8.9e-44 149.7 0.0 1.4e-43 149.0 0.0 1.3 1 0 0 1 1 1 1 ThiF family ATG7_N PF16420.5 EKE42992.1 - 4.9e-28 98.6 0.3 4.8e-26 92.1 0.3 2.2 1 1 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus Shikimate_DH PF01488.20 EKE42992.1 - 0.1 12.7 0.0 0.6 10.2 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DUF4788 PF16032.5 EKE42992.1 - 0.11 11.5 0.0 0.21 10.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4788) HTH_Crp_2 PF13545.6 EKE42992.1 - 0.11 12.5 0.0 0.54 10.3 0.0 2.1 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain FERM_N_2 PF18038.1 EKE42992.1 - 0.12 13.2 0.0 0.28 12.0 0.0 1.7 1 0 0 1 1 1 0 FERM N-terminal domain DUF4713 PF15831.5 EKE42993.1 - 0.098 13.1 2.1 0.19 12.2 2.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Pox_A9 PF04835.12 EKE42993.1 - 0.11 12.7 1.5 0.21 11.8 1.5 1.5 1 0 0 1 1 1 0 A9 protein conserved region Pox_EPC_I2-L1 PF12575.8 EKE42993.1 - 0.11 12.8 3.5 0.26 11.5 0.4 2.5 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Erp_C PF06780.11 EKE42993.1 - 0.25 11.4 11.4 1.5 8.9 2.2 2.6 2 1 0 2 2 2 0 Erp protein C-terminus HIP1_clath_bdg PF16515.5 EKE42993.1 - 0.88 10.2 15.1 5.2 7.8 2.4 2.8 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 GcnA_N PF18229.1 EKE42994.1 - 0.1 12.6 1.6 0.22 11.6 0.7 2.0 2 0 0 2 2 2 0 N-acetyl-beta-D-glucosaminidase N-terminal domain EamA PF00892.20 EKE42996.1 - 9.7e-07 29.0 4.7 9.7e-07 29.0 4.7 3.7 2 1 0 2 2 2 1 EamA-like transporter family CRT-like PF08627.10 EKE42996.1 - 0.0017 17.3 14.8 0.0035 16.4 14.4 1.7 1 1 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like COX4_pro_2 PF07835.12 EKE42996.1 - 0.026 14.6 0.2 0.13 12.4 0.2 2.3 1 0 0 1 1 1 0 Bacterial aa3 type cytochrome c oxidase subunit IV PUNUT PF16913.5 EKE42996.1 - 0.13 11.4 18.3 0.028 13.6 12.6 2.2 1 1 0 2 2 2 0 Purine nucleobase transmembrane transport TNFR_16_TM PF18422.1 EKE42996.1 - 7.9 6.5 6.9 0.85 9.6 0.5 2.5 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain Ca_hom_mod PF14798.6 EKE42997.1 - 0.011 14.9 0.6 0.055 12.6 0.3 2.0 1 1 1 2 2 2 0 Calcium homeostasis modulator EI24 PF07264.11 EKE42997.1 - 0.11 12.8 7.8 0.34 11.1 7.8 1.9 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF2574 PF10836.8 EKE42997.1 - 2.1 8.3 4.1 22 5.0 1.1 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2574) Peptidase_C1 PF00112.23 EKE42998.1 - 1.9e-07 31.4 0.5 6.1e-05 23.2 0.0 2.6 2 1 0 2 2 2 2 Papain family cysteine protease PKcGMP_CC PF16808.5 EKE42999.1 - 2.1e-06 27.4 4.0 3.7e-06 26.7 4.0 1.4 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase ECM11 PF15463.6 EKE42999.1 - 0.053 14.1 2.4 3.3 8.3 0.8 2.1 2 0 0 2 2 2 0 Extracellular mutant protein 11 Wtap PF17098.5 EKE42999.1 - 0.053 13.4 0.9 0.12 12.3 0.4 1.8 1 1 1 2 2 2 0 WTAP/Mum2p family Ntox35 PF15534.6 EKE42999.1 - 0.074 13.5 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial toxin 35 Myb_DNA-bind_4 PF13837.6 EKE42999.1 - 0.096 13.1 2.2 0.15 12.4 1.5 1.6 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain Ribul_P_3_epim PF00834.19 EKE43000.1 - 1.6e-69 233.3 1.7 1.8e-69 233.1 1.7 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family His_biosynth PF00977.21 EKE43000.1 - 0.00034 20.1 0.5 0.059 12.8 0.0 2.5 1 1 1 2 2 2 2 Histidine biosynthesis protein QRPTase_C PF01729.19 EKE43000.1 - 0.00042 20.1 1.3 0.0017 18.1 0.6 1.9 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain Mem_trans PF03547.18 EKE43001.1 - 8.3e-08 31.0 1.0 1.4e-07 30.3 1.0 1.3 1 0 0 1 1 1 1 Membrane transport protein TetR_C_8 PF14278.6 EKE43003.1 - 0.031 14.4 0.1 0.044 13.9 0.1 1.3 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region Pkinase_Tyr PF07714.17 EKE43004.1 - 6.7e-55 186.2 0.1 1.5e-54 185.0 0.1 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EKE43004.1 - 4.1e-54 183.7 1.3 4.1e-54 183.7 1.3 2.5 3 0 0 3 3 3 1 Protein kinase domain Kdo PF06293.14 EKE43004.1 - 2e-05 24.1 0.0 3.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DHR-2 PF06920.13 EKE43005.1 - 2.7e-69 234.2 14.9 2.7e-69 234.2 14.9 2.3 2 0 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 EKE43005.1 - 2.9e-30 105.5 2.8 9.6e-30 103.8 2.8 2.0 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF948 PF06103.11 EKE43005.1 - 0.022 15.0 0.4 15 5.9 0.0 4.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) PGM_PMM_I PF02878.16 EKE43006.1 - 4.2e-41 139.9 0.0 1.2e-40 138.4 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EKE43006.1 - 1.6e-22 80.0 0.0 3.5e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EKE43006.1 - 2.7e-12 46.9 0.4 5.5e-12 45.9 0.1 1.7 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EKE43006.1 - 9.9e-05 22.4 0.0 0.00025 21.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Ran_BP1 PF00638.18 EKE43007.1 - 5.2e-24 84.9 0.2 6.3e-24 84.6 0.2 1.1 1 0 0 1 1 1 1 RanBP1 domain HD_4 PF13328.6 EKE43008.1 - 2.7e-16 59.7 0.0 3.5e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.22 EKE43008.1 - 3.7e-05 23.9 0.4 6.5e-05 23.1 0.4 1.4 1 0 0 1 1 1 1 HD domain SIKE PF05769.11 EKE43008.1 - 0.033 14.1 0.1 0.049 13.6 0.1 1.2 1 0 0 1 1 1 0 SIKE family AGOG PF09171.10 EKE43008.1 - 0.086 12.2 0.1 0.13 11.6 0.1 1.3 1 1 0 1 1 1 0 N-glycosylase/DNA lyase KNOX2 PF03791.13 EKE43009.1 - 0.093 12.2 0.1 0.22 11.0 0.1 1.6 2 0 0 2 2 2 0 KNOX2 domain SF-assemblin PF06705.11 EKE43010.1 - 0.53 9.6 11.2 0.068 12.5 5.1 1.9 1 1 0 2 2 2 0 SF-assemblin/beta giardin T6PP_N PF18572.1 EKE43010.1 - 0.78 9.6 7.7 0.21 11.4 3.5 2.1 2 2 0 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Cas6b_C PF17262.2 EKE43010.1 - 2.1 8.5 6.6 2 8.5 1.1 2.5 2 1 1 3 3 3 0 Cas6b C-terminal domain VPS9 PF02204.18 EKE43011.1 - 4.1e-21 75.2 0.1 9.5e-21 74.0 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Cys_rich_KTR PF14205.6 EKE43011.1 - 0.043 13.6 0.2 0.13 12.0 0.2 1.8 1 0 0 1 1 1 0 Cysteine-rich KTR DUF3087 PF11286.8 EKE43012.1 - 0.22 11.0 2.5 9.6 5.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) Saf_2TM PF18303.1 EKE43012.1 - 0.5 10.0 4.2 1.9 8.1 0.2 2.4 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Cytomega_TRL10 PF06084.11 EKE43012.1 - 0.59 10.1 1.5 1.6 8.7 0.1 2.0 2 0 0 2 2 2 0 Cytomegalovirus TRL10 protein Sigma_reg_N PF13800.6 EKE43012.1 - 7.9 6.8 13.9 0.28 11.5 0.5 3.3 4 0 0 4 4 4 0 Sigma factor regulator N-terminal KAR9 PF08580.10 EKE43013.1 - 0.29 9.6 0.1 0.36 9.3 0.1 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 PCI PF01399.27 EKE43014.1 - 9e-17 61.5 4.1 3.3e-16 59.7 2.9 2.4 3 0 0 3 3 3 1 PCI domain RPN6_N PF18055.1 EKE43014.1 - 0.0034 17.7 1.1 0.011 16.1 0.1 2.4 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain Diphthami_syn_2 PF01902.17 EKE43015.1 - 2.6e-36 125.2 0.1 9.1e-36 123.4 0.1 1.7 1 1 0 1 1 1 1 Diphthamide synthase QueC PF06508.13 EKE43015.1 - 0.029 13.9 0.1 0.46 10.0 0.0 2.2 1 1 1 2 2 2 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EKE43015.1 - 0.049 12.4 0.0 0.077 11.8 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase ThiI PF02568.14 EKE43015.1 - 0.067 12.8 0.0 0.15 11.6 0.0 1.7 1 1 1 2 2 2 0 Thiamine biosynthesis protein (ThiI) Peptidase_S74 PF13884.6 EKE43016.1 - 5.2e-15 55.5 0.0 1.2e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 Chaperone of endosialidase MBR1 PF17058.5 EKE43016.1 - 0.0055 17.0 4.1 0.0055 17.0 1.0 2.3 2 0 0 2 2 2 1 Mitochondrial biogenesis regulation protein 1 DUF1741 PF08427.10 EKE43016.1 - 0.42 10.2 7.1 4.6 6.8 1.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1741) THOC7 PF05615.13 EKE43016.1 - 0.98 9.7 7.2 2.7 8.3 7.2 1.7 1 0 0 1 1 1 0 Tho complex subunit 7 DRY_EERY PF09750.9 EKE43016.1 - 1.9 8.8 6.9 0.8 10.0 2.6 2.1 2 0 0 2 2 2 0 Alternative splicing regulator SpoU_methylase PF00588.19 EKE43018.1 - 9.8e-27 93.9 0.1 1.7e-26 93.1 0.1 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family RRM_1 PF00076.22 EKE43018.1 - 9.2e-14 51.0 0.2 1.9e-13 50.0 0.2 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltrn_RNA_4 PF09936.9 EKE43018.1 - 9.7e-06 25.6 0.0 0.00046 20.1 0.0 2.4 1 1 0 1 1 1 1 SAM-dependent RNA methyltransferase RRM_3 PF08777.11 EKE43018.1 - 0.00059 19.8 0.2 0.002 18.1 0.2 1.9 1 0 0 1 1 1 1 RNA binding motif RRM_7 PF16367.5 EKE43018.1 - 0.0017 18.5 0.1 0.028 14.5 0.1 2.6 2 1 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.5 EKE43018.1 - 0.0051 16.6 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Occluded RNA-recognition motif Abhydrolase_1 PF00561.20 EKE43019.1 - 0.00042 20.0 0.0 0.0007 19.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 EKE43019.1 - 0.024 14.5 0.0 0.044 13.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_6 PF12697.7 EKE43019.1 - 0.033 14.8 0.0 0.048 14.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF915 PF06028.11 EKE43019.1 - 0.086 12.2 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Thioredoxin PF00085.20 EKE43020.1 - 4.8e-12 45.8 0.0 6.5e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.16 EKE43020.1 - 0.057 13.2 0.0 0.068 13.0 0.0 1.2 1 0 0 1 1 1 0 Mitosis protein DIM1 DNA_pol_B PF00136.21 EKE43021.1 - 2.1e-142 475.1 3.3 3.5e-142 474.4 3.3 1.4 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EKE43021.1 - 8.6e-69 232.2 5.9 2.8e-68 230.5 5.3 2.1 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EKE43021.1 - 8.1e-14 51.8 11.5 2.4e-13 50.3 11.5 1.9 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta Cytochrom_c3_2 PF14537.6 EKE43021.1 - 0.15 12.5 15.3 0.41 11.1 15.3 1.7 1 0 0 1 1 1 0 Cytochrome c3 Paired_CXXCH_1 PF09699.10 EKE43021.1 - 0.2 11.4 3.5 7.4 6.4 1.0 2.5 1 1 2 3 3 3 0 Doubled CXXCH motif (Paired_CXXCH_1) Rhodanese_C PF12368.8 EKE43021.1 - 0.44 11.0 6.7 1.3 9.5 0.9 2.5 2 0 0 2 2 2 0 Rhodanase C-terminal HTH_10 PF04967.12 EKE43022.1 - 0.0097 15.7 0.5 0.43 10.4 0.1 3.0 3 0 0 3 3 3 1 HTH DNA binding domain DUF1392 PF07154.11 EKE43022.1 - 0.013 15.6 1.3 0.089 12.9 0.1 2.5 2 1 0 3 3 3 0 Protein of unknown function (DUF1392) TF_Zn_Ribbon PF08271.12 EKE43022.1 - 0.05 13.1 2.6 0.17 11.4 2.6 1.9 1 0 0 1 1 1 0 TFIIB zinc-binding RVT_1 PF00078.27 EKE43022.1 - 0.056 13.0 1.4 0.061 12.8 0.2 1.6 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) NMT_C PF02799.15 EKE43022.1 - 0.2 11.1 1.2 0.72 9.3 0.1 2.4 3 0 0 3 3 3 0 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Bestrophin PF01062.21 EKE43022.1 - 0.58 9.5 3.0 0.47 9.8 0.2 2.0 1 1 1 2 2 2 0 Bestrophin, RFP-TM, chloride channel NPR2 PF06218.11 EKE43023.1 - 3.7e-37 128.1 4.5 2.9e-25 88.9 0.2 2.3 1 1 1 2 2 2 2 Nitrogen permease regulator 2 NPR3 PF03666.13 EKE43023.1 - 0.006 15.4 0.0 0.17 10.6 0.0 2.2 1 1 1 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 DUF2095 PF09868.9 EKE43023.1 - 0.67 9.9 4.2 0.34 10.9 0.6 2.2 2 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2095) Latarcin PF10279.9 EKE43024.1 - 0.11 12.9 1.1 0.14 12.5 1.1 1.4 1 1 0 1 1 1 0 Latarcin precursor SOAR PF16533.5 EKE43024.1 - 0.13 12.3 1.4 0.18 11.8 1.4 1.2 1 0 0 1 1 1 0 STIM1 Orai1-activating region FH2 PF02181.23 EKE43025.1 - 2.1e-54 185.1 11.5 2.1e-54 185.1 11.5 3.4 2 1 2 4 4 4 1 Formin Homology 2 Domain DUF3361 PF11841.8 EKE43025.1 - 2.3e-07 30.9 3.8 2.3e-07 30.9 3.8 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF3361) Drf_FH1 PF06346.12 EKE43025.1 - 3.6e-05 23.5 65.8 5.7e-05 22.9 65.8 1.2 1 0 0 1 1 1 1 Formin Homology Region 1 TSC22 PF01166.18 EKE43025.1 - 0.0011 19.2 0.9 0.0011 19.2 0.9 4.8 5 1 0 5 5 5 1 TSC-22/dip/bun family TPR_MLP1_2 PF07926.12 EKE43025.1 - 0.39 10.8 24.1 0.1 12.7 12.9 3.6 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Shugoshin_N PF07558.11 EKE43025.1 - 0.5 10.3 8.9 0.094 12.6 1.9 3.2 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region TFX_C PF14601.6 EKE43025.1 - 0.59 10.1 4.0 6.1 6.9 0.3 3.6 3 0 0 3 3 3 0 DNA_binding protein, TFX, C-term DUF2205 PF10224.9 EKE43025.1 - 1.6 8.8 7.6 9.7 6.3 0.1 3.2 2 0 0 2 2 2 0 Short coiled-coil protein HALZ PF02183.18 EKE43025.1 - 2.5 8.4 20.2 0.32 11.2 3.2 3.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper RtcB PF01139.17 EKE43025.1 - 4.3 6.4 7.2 8.8 5.4 1.5 2.7 3 0 0 3 3 3 0 tRNA-splicing ligase RtcB Alpha_kinase PF02816.18 EKE43026.1 - 3.6e-46 157.6 2.5 5.8e-46 156.9 2.5 1.3 1 0 0 1 1 1 1 Alpha-kinase family SH3_1 PF00018.28 EKE43026.1 - 4.4e-16 58.2 0.7 9.7e-12 44.3 0.2 2.6 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EKE43026.1 - 2.2e-15 56.1 1.5 3.3e-09 36.3 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 EKE43026.1 - 5.9e-14 51.7 0.0 3.8e-08 33.1 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain Na_H_Exchanger PF00999.21 EKE43027.1 - 6.3e-55 186.5 43.7 7.4e-55 186.3 43.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family CagS PF16707.5 EKE43027.1 - 1.5 8.8 7.8 0.079 13.0 0.8 2.4 3 0 0 3 3 3 0 Cag pathogenicity island protein S of Helicobacter pylori TrbC PF04956.13 EKE43027.1 - 4.5 7.6 12.7 0.03 14.5 2.4 2.8 2 2 1 3 3 3 0 TrbC/VIRB2 family Phage_holin_3_3 PF16083.5 EKE43027.1 - 6.4 7.0 11.9 0.73 10.0 0.1 3.8 2 1 1 3 3 3 0 LydA holin phage, holin superfamily III EF-hand_7 PF13499.6 EKE43029.1 - 5.2e-12 46.1 0.0 2.4e-08 34.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EKE43029.1 - 2.6e-10 39.1 0.0 0.023 14.2 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EKE43029.1 - 6.2e-09 35.1 0.0 0.1 12.5 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EKE43029.1 - 6.2e-06 25.5 0.0 0.042 13.4 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EKE43029.1 - 0.00097 18.9 0.0 0.09 12.6 0.0 2.8 2 1 1 3 3 3 1 EF-hand domain pair TLD PF07534.16 EKE43030.1 - 0.0034 17.6 0.7 0.01 16.0 0.1 2.2 2 1 0 2 2 2 1 TLD DUF1548 PF07579.11 EKE43030.1 - 0.55 10.6 4.3 0.31 11.4 1.9 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1548) FlxA PF14282.6 EKE43030.1 - 1.1 9.3 6.8 7.4 6.6 1.0 2.2 2 0 0 2 2 2 0 FlxA-like protein Peptidase_C1 PF00112.23 EKE43031.1 - 1.1e-56 192.3 2.7 1.8e-56 191.7 2.7 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EKE43031.1 - 6.9e-07 29.6 0.2 1.5e-06 28.5 0.2 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EKE43031.1 - 0.005 15.7 0.0 0.1 11.3 0.0 2.0 2 0 0 2 2 2 1 Peptidase C1-like family Cofilin_ADF PF00241.20 EKE43032.1 - 2.4e-36 124.2 0.4 2.7e-36 124.0 0.4 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF2207 PF09972.9 EKE43033.1 - 0.022 13.6 0.9 0.026 13.3 0.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) YchF-GTPase_C PF06071.13 EKE43033.1 - 0.049 13.8 0.1 0.092 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF933) Sec20 PF03908.13 EKE43033.1 - 0.5 10.3 2.5 4.2 7.3 0.0 3.0 2 1 0 3 3 3 0 Sec20 Rhomboid PF01694.22 EKE43034.1 - 2e-31 109.0 12.6 2e-31 109.0 12.6 1.8 3 0 0 3 3 3 1 Rhomboid family DUF1751 PF08551.10 EKE43034.1 - 0.0019 18.7 0.8 0.006 17.1 0.2 2.1 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) Phage_holin_3_3 PF16083.5 EKE43034.1 - 1.2 9.3 11.6 0.25 11.5 2.6 2.6 1 1 1 2 2 2 0 LydA holin phage, holin superfamily III DUF3810 PF12725.7 EKE43034.1 - 2.3 7.5 3.8 1.2 8.4 1.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) Surface_Ag_2 PF01617.17 EKE43035.1 - 1.7 8.0 6.6 2.3 7.6 1.1 2.1 2 0 0 2 2 2 0 Surface antigen PI3_PI4_kinase PF00454.27 EKE43037.1 - 1.1e-34 120.3 0.3 1.4e-34 120.1 0.3 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EKE43037.1 - 1.2e-07 31.4 0.0 2.3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 FATC domain UCH PF00443.29 EKE43038.1 - 1.6e-28 99.9 0.5 1.8e-28 99.7 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EKE43038.1 - 6.3e-10 39.1 1.6 4e-09 36.5 0.2 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase SGL PF08450.12 EKE43039.1 - 0.11 12.1 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region DUF962 PF06127.11 EKE43040.1 - 0.0098 16.0 1.2 1.3 9.2 0.2 2.9 2 1 0 2 2 2 2 Protein of unknown function (DUF962) Rotamase_3 PF13616.6 EKE43041.1 - 2.2e-22 79.8 0.0 4e-22 79.0 0.0 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EKE43041.1 - 2.5e-19 70.0 0.1 4.9e-19 69.1 0.1 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EKE43041.1 - 1.4e-07 32.4 0.3 2.8e-07 31.4 0.3 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain z-alpha PF02295.17 EKE43041.1 - 0.0068 16.4 0.1 0.014 15.4 0.1 1.5 1 0 0 1 1 1 1 Adenosine deaminase z-alpha domain DNA_alkylation PF08713.11 EKE43042.1 - 1.7e-25 90.0 0.0 2.1e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 DNA alkylation repair enzyme MNHE PF01899.16 EKE43043.1 - 3.3 7.4 8.4 1.1 9.1 2.9 2.3 2 1 0 2 2 2 0 Na+/H+ ion antiporter subunit KleE PF17394.2 EKE43043.1 - 3.5 7.9 6.6 7.5 6.8 6.6 1.6 1 0 0 1 1 1 0 Uncharacterized KleE stable inheritance protein UPF0184 PF03670.13 EKE43044.1 - 0.021 15.2 1.2 0.021 15.2 1.2 3.0 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0184) PH PF00169.29 EKE43045.1 - 5.9e-05 23.5 0.2 0.00015 22.2 0.2 1.6 1 0 0 1 1 1 1 PH domain RhoGAP PF00620.27 EKE43045.1 - 0.00037 20.4 0.2 0.00093 19.0 0.2 1.8 1 0 0 1 1 1 1 RhoGAP domain Glyco_hydro_98M PF08306.11 EKE43045.1 - 0.15 11.3 0.2 0.25 10.6 0.2 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 zf-HIT PF04438.16 EKE43048.1 - 0.0001 22.1 8.6 0.00019 21.2 8.6 1.5 1 0 0 1 1 1 1 HIT zinc finger Cnd1 PF12717.7 EKE43049.1 - 0.0014 18.7 0.1 0.0014 18.7 0.1 2.5 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 RasGEF_N_2 PF14663.6 EKE43049.1 - 0.0038 17.6 0.4 2.1 8.8 0.0 3.3 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Arm PF00514.23 EKE43049.1 - 0.15 12.1 5.0 11 6.2 0.0 5.3 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat DUF3361 PF11841.8 EKE43049.1 - 1.3 8.9 10.6 7.6 6.5 1.4 3.4 2 1 0 3 3 3 0 Domain of unknown function (DUF3361) UNC45-central PF11701.8 EKE43049.1 - 4.5 7.2 6.4 2 8.4 0.3 3.0 3 1 0 3 3 3 0 Myosin-binding striated muscle assembly central Pkinase PF00069.25 EKE43050.1 - 3.9e-66 223.1 0.0 4.8e-66 222.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EKE43050.1 - 2.6e-31 108.9 0.0 2.5e-30 105.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EKE43050.1 - 0.0011 18.4 1.3 0.013 14.8 0.2 2.6 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 EKE43050.1 - 0.03 14.3 0.1 0.11 12.4 0.0 1.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family zf-C3HC4_2 PF13923.6 EKE43051.1 - 2.2e-08 33.8 9.2 2.2e-08 33.8 9.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EKE43051.1 - 6.5e-07 29.1 7.0 1.7e-06 27.8 7.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EKE43051.1 - 7.2e-07 29.0 9.7 2.5e-06 27.2 9.7 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EKE43051.1 - 8.1e-07 29.1 11.7 8.7e-07 29.0 6.3 3.0 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EKE43051.1 - 9.3e-06 25.7 3.3 2.5e-05 24.3 3.3 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_5 PF14634.6 EKE43051.1 - 6.8e-05 22.7 10.7 0.0002 21.3 10.7 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 EKE43051.1 - 0.0001 22.0 4.9 0.0004 20.1 4.9 2.1 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 EKE43051.1 - 0.00011 22.2 3.8 0.00011 22.2 3.8 3.3 4 0 0 4 4 4 1 RING-type zinc-finger zf-RING_2 PF13639.6 EKE43051.1 - 0.00012 22.3 9.9 0.00012 22.3 9.9 2.5 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 EKE43051.1 - 0.00093 19.0 8.4 0.0023 17.7 8.4 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EKE43051.1 - 0.0022 17.8 3.8 0.005 16.7 3.8 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EKE43051.1 - 0.008 16.4 6.5 0.008 16.4 6.5 2.3 2 0 0 2 2 1 1 RING-H2 zinc finger domain F-box-like PF12937.7 EKE43051.1 - 0.12 12.3 0.1 0.26 11.2 0.1 1.6 1 0 0 1 1 1 0 F-box-like zf-P11 PF03854.14 EKE43051.1 - 0.18 11.5 5.2 0.62 9.8 5.2 1.9 1 1 0 1 1 1 0 P-11 zinc finger zf-C3H2C3 PF17122.5 EKE43051.1 - 0.21 11.7 8.5 0.55 10.3 8.5 1.8 1 0 0 1 1 1 0 Zinc-finger zinc-ribbons_6 PF07191.12 EKE43051.1 - 0.45 10.5 4.4 1.2 9.1 4.4 1.7 1 0 0 1 1 1 0 zinc-ribbons Baculo_IE-1 PF05290.11 EKE43051.1 - 0.81 9.6 15.0 4.9 7.1 4.4 4.1 3 1 1 4 4 4 0 Baculovirus immediate-early protein (IE-0) SPO22 PF08631.10 EKE43052.1 - 8.1e-10 38.6 17.0 3.4e-05 23.5 3.9 3.7 1 1 2 3 3 3 3 Meiosis protein SPO22/ZIP4 like TPR_2 PF07719.17 EKE43052.1 - 6.5e-07 29.0 15.0 0.95 9.7 0.3 7.2 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EKE43052.1 - 9.4e-07 28.6 27.0 0.095 13.0 0.1 8.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 EKE43052.1 - 3.5e-05 24.0 0.0 6.9 7.0 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EKE43052.1 - 3.8e-05 24.0 2.8 0.034 14.8 0.2 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat BORCS7 PF16088.5 EKE43052.1 - 0.0022 18.2 1.8 0.11 12.8 0.2 3.7 2 0 0 2 2 2 1 BLOC-1-related complex sub-unit 7 TPR_1 PF00515.28 EKE43052.1 - 0.025 14.4 21.8 6.8 6.7 0.1 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat HHH_8 PF14716.6 EKE43052.1 - 0.029 14.7 0.9 2.6 8.5 0.1 3.9 3 0 0 3 3 3 0 Helix-hairpin-helix domain PI_PP_I PF18363.1 EKE43052.1 - 0.98 9.6 3.8 7.7 6.8 0.1 3.4 2 1 1 3 3 3 0 Phosphoinositide phosphatase insertion domain TPR_10 PF13374.6 EKE43052.1 - 2.6 8.0 3.7 87 3.2 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat IDEAL PF08858.10 EKE43052.1 - 3.1 7.6 8.6 4 7.2 0.9 3.3 2 0 0 2 2 2 0 IDEAL domain HEPN PF05168.14 EKE43053.1 - 0.03 14.5 2.4 0.04 14.1 0.6 2.0 2 0 0 2 2 2 0 HEPN domain TPR_19 PF14559.6 EKE43053.1 - 0.047 14.2 0.1 0.11 13.0 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EKE43053.1 - 0.081 13.2 0.6 1 9.7 0.6 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 RabGAP-TBC PF00566.18 EKE43054.1 - 3.3e-35 121.7 4.7 4.7e-35 121.2 4.7 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Archamoebae/Entamoeba_nuttalli_P19-ENU1_v1/GCA_000257125.1_ENU1_v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Archamoebae/Entamoeba_nuttalli_P19-ENU1_v1/GCA_000257125.1_ENU1_v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Archamoebae/Entamoeba_nuttalli_P19-ENU1_v1/GCA_000257125.1_ENU1_v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Archamoebae/Entamoeba_nuttalli_P19-ENU1_v1/GCA_000257125.1_ENU1_v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 02:22:47 2019 # [ok]