# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Cdc6_C PF09079.11 AIF82085.1 - 8.9e-10 38.4 0.1 2.5e-09 37.0 0.1 1.7 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_16 PF13191.6 AIF82085.1 - 1.2e-08 35.5 2.8 1.1e-06 29.1 0.4 3.2 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 AIF82085.1 - 4.6e-07 30.3 0.0 1.4e-06 28.8 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AIF82085.1 - 6.5e-06 26.5 0.0 3.1e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 AIF82085.1 - 2.1e-05 24.5 0.5 0.079 12.9 0.0 2.7 2 1 1 3 3 3 2 ATPase domain predominantly from Archaea Bac_DnaA PF00308.18 AIF82085.1 - 0.00088 19.2 0.2 0.011 15.6 0.1 2.1 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_33 PF13671.6 AIF82085.1 - 0.0092 16.1 0.0 0.028 14.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 AIF82085.1 - 0.013 15.3 0.0 0.048 13.4 0.0 1.9 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 AIF82085.1 - 0.016 15.6 0.0 0.26 11.7 0.0 2.5 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.22 AIF82085.1 - 0.02 14.1 0.0 0.039 13.1 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_assoc_2 PF16193.5 AIF82085.1 - 0.031 14.6 0.1 0.074 13.4 0.1 1.6 1 0 0 1 1 1 0 AAA C-terminal domain AAA_25 PF13481.6 AIF82085.1 - 0.033 13.8 0.4 5.3 6.6 0.0 3.0 1 1 1 3 3 3 0 AAA domain CBFD_NFYB_HMF PF00808.23 AIF82085.1 - 0.043 14.1 0.0 2.9 8.2 0.0 3.3 2 1 1 3 3 3 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ABC_tran PF00005.27 AIF82085.1 - 0.052 14.1 0.2 0.41 11.2 0.0 2.5 2 2 2 4 4 4 0 ABC transporter AAA_5 PF07728.14 AIF82085.1 - 0.055 13.5 0.0 2.6 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 AIF82085.1 - 0.064 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_lid_10 PF17872.1 AIF82085.1 - 0.064 13.4 1.0 0.13 12.4 0.1 2.0 2 0 0 2 2 2 0 AAA lid domain Thymidylate_kin PF02223.17 AIF82085.1 - 0.082 12.6 0.1 22 4.7 0.0 2.9 3 0 0 3 3 2 0 Thymidylate kinase AAA_29 PF13555.6 AIF82085.1 - 0.086 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3987 PF13148.6 AIF82085.1 - 0.089 11.8 0.0 0.089 11.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3987) SMC_N PF02463.19 AIF82085.1 - 0.11 11.9 0.1 0.75 9.2 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.15 AIF82085.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 NTPase ApeA_NTD1 PF18862.1 AIF82086.1 - 2.7e-27 96.1 2.6 3e-27 95.9 2.6 1.0 1 0 0 1 1 1 1 ApeA N-terminal domain 1 UPF0193 PF05250.11 AIF82087.1 - 0.0058 16.4 0.2 0.0082 16.0 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) BLOC1S3 PF15753.5 AIF82087.1 - 0.073 13.2 0.3 0.097 12.8 0.3 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 ArsA_ATPase PF02374.15 AIF82087.1 - 0.088 12.0 0.2 5.5 6.1 0.1 2.0 1 1 0 2 2 2 0 Anion-transporting ATPase UspB PF10625.9 AIF82087.1 - 0.11 12.4 0.2 0.25 11.3 0.0 1.7 2 0 0 2 2 2 0 Universal stress protein B (UspB) NAD_binding_1 PF00175.21 AIF82087.1 - 0.25 12.0 0.4 0.54 10.9 0.3 1.6 1 1 1 2 2 2 0 Oxidoreductase NAD-binding domain Rad51 PF08423.11 AIF82088.1 - 2.5e-11 43.3 0.0 3.2e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Rad51 DZR PF12773.7 AIF82088.1 - 0.066 13.2 2.1 0.12 12.4 2.1 1.3 1 0 0 1 1 1 0 Double zinc ribbon RNA_POL_M_15KD PF02150.16 AIF82088.1 - 0.069 13.0 5.5 0.21 11.5 0.7 2.4 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit zf-ribbon_3 PF13248.6 AIF82088.1 - 0.082 12.4 4.6 0.44 10.0 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 AIF82088.1 - 1.1 9.1 6.5 1.2 9.0 0.6 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf_UBZ PF18439.1 AIF82088.1 - 2.3 7.9 4.4 17 5.1 1.1 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Zn_Tnp_IS1595 PF12760.7 AIF82088.1 - 6.5 6.8 5.7 1.3 9.1 0.1 2.5 3 0 0 3 3 3 0 Transposase zinc-ribbon domain ArgoL1 PF08699.10 AIF82090.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Argonaute linker 1 domain DNA_pol_B PF00136.21 AIF82091.1 - 2.7e-34 118.7 0.0 4.8e-34 117.8 0.0 1.4 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 AIF82091.1 - 7.6e-10 38.4 0.0 2.7e-07 30.0 0.0 2.3 1 1 1 2 2 2 2 DNA polymerase family B, exonuclease domain IL1 PF00340.19 AIF82091.1 - 0.016 14.9 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 Interleukin-1 / 18 Methyltransf_3 PF01596.17 AIF82092.1 - 1.6e-34 118.9 0.4 3.6e-34 117.8 0.4 1.5 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 AIF82092.1 - 1.6e-16 61.2 0.0 2.7e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF82092.1 - 7.5e-12 45.3 0.0 9.8e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AIF82092.1 - 5.8e-08 32.7 0.0 8.5e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 AIF82092.1 - 5.8e-08 33.3 0.0 1e-07 32.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF82092.1 - 5.7e-06 26.9 0.0 2e-05 25.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 AIF82092.1 - 0.00028 20.6 0.1 0.00042 20.0 0.1 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F GCD14 PF08704.10 AIF82092.1 - 0.0003 20.6 0.0 0.00038 20.2 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit MTS PF05175.14 AIF82092.1 - 0.00042 19.9 0.0 0.00065 19.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 AIF82092.1 - 0.0012 18.8 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 AIF82092.1 - 0.004 16.8 0.1 0.0069 16.1 0.0 1.3 1 1 0 1 1 1 1 Conserved hypothetical protein 95 CmcI PF04989.12 AIF82092.1 - 0.0078 15.9 0.0 0.0096 15.6 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase PrmA PF06325.13 AIF82092.1 - 0.0094 15.4 0.2 0.012 15.0 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 AIF82092.1 - 0.011 15.0 0.1 0.015 14.7 0.1 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MetW PF07021.12 AIF82092.1 - 0.022 14.3 0.1 0.034 13.8 0.1 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW UPF0020 PF01170.18 AIF82092.1 - 0.036 13.8 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.10 AIF82092.1 - 0.043 13.4 0.0 0.058 13.0 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_23 PF13489.6 AIF82092.1 - 0.096 12.5 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain OTCace_N PF02729.21 AIF82093.1 - 9e-43 145.8 0.0 1.7e-42 144.9 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 AIF82093.1 - 1.2e-31 109.9 0.0 1.7e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain DUF1801 PF08818.11 AIF82094.1 - 0.0043 17.5 0.0 0.0056 17.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DU1801) F420_oxidored PF03807.17 AIF82097.1 - 2.7e-14 53.5 0.1 3.8e-14 53.0 0.1 1.2 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 AIF82097.1 - 2.9e-05 24.3 0.0 4.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 AIF82097.1 - 0.0021 18.0 0.1 0.0028 17.5 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 AIF82097.1 - 0.0045 17.0 0.0 0.0064 16.5 0.0 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 AIF82097.1 - 0.015 14.9 0.0 0.12 12.0 0.0 2.0 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Rossmann-like PF10727.9 AIF82097.1 - 0.024 14.5 0.3 0.13 12.1 0.2 2.1 2 0 0 2 2 2 0 Rossmann-like domain Shikimate_DH PF01488.20 AIF82097.1 - 0.042 13.9 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 AIF82097.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 AIF82097.1 - 0.17 11.5 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF347 PF03988.12 AIF82098.1 - 0.0064 16.7 0.1 0.0074 16.5 0.1 1.2 1 0 0 1 1 1 1 Repeat of Unknown Function (DUF347) Insulin_TMD PF17870.1 AIF82098.1 - 0.08 13.0 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Gram_pos_anchor PF00746.21 AIF82098.1 - 0.38 10.7 1.3 0.4 10.7 0.1 1.7 2 0 0 2 2 2 0 LPXTG cell wall anchor motif eIF-6 PF01912.18 AIF82099.1 - 1.6e-65 220.2 0.3 1.9e-65 220.0 0.3 1.1 1 0 0 1 1 1 1 eIF-6 family MoCF_biosynth PF00994.24 AIF82100.1 - 1.5e-34 118.7 0.1 2e-34 118.3 0.1 1.2 1 0 0 1 1 1 1 Probable molybdopterin binding domain CreD PF06123.12 AIF82101.1 - 2.7 6.7 5.3 4.2 6.0 5.3 1.4 1 1 0 1 1 1 0 Inner membrane protein CreD Aminotran_4 PF01063.19 AIF82102.1 - 7.3e-48 163.4 0.0 8.5e-48 163.1 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV DUF3944 PF13099.6 AIF82102.1 - 0.028 14.3 0.0 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3944) AA_kinase PF00696.28 AIF82103.1 - 3.2e-25 89.1 0.4 5.1e-25 88.5 0.4 1.4 1 0 0 1 1 1 1 Amino acid kinase family DUF2470 PF10615.9 AIF82104.1 - 0.029 15.0 0.0 0.035 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2470) C1_1 PF00130.22 AIF82105.1 - 0.0048 16.8 0.8 0.0056 16.5 0.8 1.1 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.10 AIF82105.1 - 0.0051 16.9 1.5 0.5 10.5 0.3 2.1 2 0 0 2 2 2 2 Zinc ribbon domain C1_2 PF03107.16 AIF82105.1 - 0.028 14.7 0.8 0.034 14.5 0.8 1.2 1 0 0 1 1 1 0 C1 domain Zn_Tnp_IS91 PF14319.6 AIF82105.1 - 0.043 13.9 1.0 0.052 13.6 1.0 1.2 1 0 0 1 1 1 0 Transposase zinc-binding domain ADD_DNMT3 PF17980.1 AIF82105.1 - 0.053 13.5 2.2 0.09 12.8 2.2 1.4 1 1 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 Desulfoferrod_N PF06397.12 AIF82105.1 - 0.06 13.0 0.7 0.06 13.0 0.7 2.1 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain A2L_zn_ribbon PF08792.10 AIF82105.1 - 0.062 13.0 4.1 3.4 7.5 0.2 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain ZZ PF00569.17 AIF82105.1 - 0.14 12.0 2.4 4.1 7.3 0.1 2.1 1 1 1 2 2 2 0 Zinc finger, ZZ type Rubredoxin_2 PF18073.1 AIF82105.1 - 0.26 11.1 0.9 0.26 11.1 0.9 1.9 2 0 0 2 2 2 0 Rubredoxin metal binding domain HTH_45 PF14947.6 AIF82106.1 - 1.7e-05 24.7 0.1 3.1e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_20 PF12840.7 AIF82106.1 - 0.00013 21.9 0.1 0.00026 21.0 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain DUF1724 PF08350.10 AIF82106.1 - 0.00041 20.4 0.0 0.0011 19.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1724) DUF4423 PF14394.6 AIF82106.1 - 0.0017 18.1 0.1 0.0031 17.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) HTH_24 PF13412.6 AIF82106.1 - 0.0038 16.8 0.0 0.01 15.4 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 AIF82106.1 - 0.0079 16.1 0.1 0.017 15.0 0.1 1.6 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 AIF82106.1 - 0.027 14.5 0.3 0.068 13.2 0.1 1.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_5 PF01022.20 AIF82106.1 - 0.031 14.1 0.1 0.071 13.0 0.1 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR PF01047.22 AIF82106.1 - 0.043 13.7 0.1 0.096 12.6 0.1 1.5 1 0 0 1 1 1 0 MarR family SnoaL_2 PF12680.7 AIF82108.1 - 2.4e-30 105.2 0.0 4.9e-19 68.9 0.2 2.1 2 0 0 2 2 2 2 SnoaL-like domain SnoaL PF07366.12 AIF82108.1 - 1.8e-29 102.1 0.0 4.3e-25 87.9 0.0 3.1 3 0 0 3 3 3 3 SnoaL-like polyketide cyclase LEH PF07858.12 AIF82108.1 - 3.9e-09 36.7 1.1 0.0048 17.0 0.0 3.7 2 2 0 2 2 2 2 Limonene-1,2-epoxide hydrolase catalytic domain SnoaL_3 PF13474.6 AIF82108.1 - 2.5e-05 24.5 0.0 0.15 12.3 0.0 2.3 2 0 0 2 2 2 2 SnoaL-like domain DUF4440 PF14534.6 AIF82108.1 - 0.00037 20.9 0.0 0.61 10.5 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4440) DUF4878 PF12870.7 AIF82108.1 - 0.00057 20.2 0.0 0.001 19.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4878) Kelch_1 PF01344.25 AIF82109.1 - 1e-70 233.1 0.7 2.7e-13 49.3 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 AIF82109.1 - 1.3e-51 171.3 0.2 4.4e-09 36.3 0.0 6.4 4 2 2 6 6 6 6 Kelch motif Kelch_2 PF07646.15 AIF82109.1 - 6.2e-38 127.4 0.0 1.7e-05 24.6 0.0 6.8 6 1 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 AIF82109.1 - 6.7e-32 109.3 3.5 6.3e-06 26.1 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 AIF82109.1 - 5.8e-31 106.2 11.1 3.9e-07 30.2 0.0 6.6 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 AIF82109.1 - 2.5e-27 94.4 4.0 0.00036 20.5 0.0 6.3 6 0 0 6 6 6 5 Kelch motif DUF1668 PF07893.13 AIF82109.1 - 0.00023 20.7 0.1 0.24 10.7 0.0 3.0 1 1 3 4 4 4 3 Protein of unknown function (DUF1668) ADH_N_2 PF16884.5 AIF82110.1 - 1.6e-32 111.6 0.0 2.8e-32 110.8 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 AIF82110.1 - 2e-17 63.4 0.0 4.4e-17 62.3 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AIF82110.1 - 2e-05 25.7 0.0 3.2e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Saf_2TM PF18303.1 AIF82111.1 - 0.095 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF2613 PF11021.8 AIF82112.1 - 0.03 14.4 3.3 0.063 13.4 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) Adeno_E3_CR2 PF02439.15 AIF82112.1 - 0.62 9.9 2.2 1.2 8.9 2.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Glyco_tran_28_C PF04101.16 AIF82114.1 - 2e-11 44.2 0.0 3.4e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.6 AIF82114.1 - 0.00014 21.2 0.0 0.11 11.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 1 NikR_C PF08753.11 AIF82115.1 - 2.2e-15 56.6 3.5 3.4e-15 55.9 3.5 1.3 1 0 0 1 1 1 1 NikR C terminal nickel binding domain RHH_1 PF01402.21 AIF82115.1 - 7.6e-06 25.7 0.1 1.4e-05 24.8 0.1 1.4 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family DUF4347 PF14252.6 AIF82115.1 - 0.064 13.1 0.0 0.12 12.2 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4347) ZnuA PF01297.17 AIF82116.1 - 1.2e-73 247.7 0.0 1.4e-73 247.4 0.0 1.1 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic HemX PF04375.14 AIF82116.1 - 0.074 12.3 1.5 1.3 8.2 0.2 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF1611_N PF17396.2 AIF82116.1 - 0.12 12.7 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_N) Rossmann-like domain Wzy_C_2 PF11846.8 AIF82116.1 - 0.15 12.0 0.2 15 5.5 0.0 2.2 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal ABC_tran PF00005.27 AIF82117.1 - 3.6e-32 111.7 0.2 3.2e-31 108.7 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 AIF82117.1 - 5.7e-11 42.8 0.9 0.00026 20.9 0.3 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AIF82117.1 - 0.00019 22.0 2.8 0.00033 21.2 2.8 1.6 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 AIF82117.1 - 0.00022 20.8 1.1 0.0026 17.2 1.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 AIF82117.1 - 0.015 15.7 1.3 0.28 11.6 1.3 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 AIF82117.1 - 0.021 14.5 1.6 0.057 13.2 0.2 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 AIF82117.1 - 0.026 13.9 0.1 0.32 10.3 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_27 PF13514.6 AIF82117.1 - 0.028 14.0 0.1 0.051 13.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 AIF82117.1 - 0.048 13.4 0.3 9 6.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_33 PF13671.6 AIF82117.1 - 0.068 13.3 0.0 0.27 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 AIF82117.1 - 0.12 12.6 0.2 6.5 7.1 0.1 2.6 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit TniB PF05621.11 AIF82117.1 - 0.13 11.6 0.3 0.49 9.8 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein ABC-3 PF00950.17 AIF82118.1 - 5.6e-66 222.7 36.4 6.5e-66 222.5 36.4 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 AIF82118.1 - 0.00016 20.8 39.3 0.0006 18.9 38.9 2.0 1 1 0 1 1 1 1 FecCD transport family Jagunal PF07086.12 AIF82118.1 - 0.0087 16.2 2.5 0.016 15.3 1.0 2.1 1 1 1 2 2 2 1 Jagunal, ER re-organisation during oogenesis AAA_lid_2 PF17863.1 AIF82118.1 - 0.11 12.3 4.0 0.26 11.1 4.0 1.7 1 0 0 1 1 1 0 AAA lid domain MarR_2 PF12802.7 AIF82119.1 - 7.9e-06 25.7 0.0 1.5e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 MarR family NUDIX PF00293.28 AIF82120.1 - 2.5e-14 53.5 0.0 3.7e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain zf-B_box PF00643.24 AIF82121.1 - 0.0031 17.6 7.2 0.0031 17.6 7.2 2.0 2 0 0 2 2 2 1 B-box zinc finger C6_DPF PF10170.9 AIF82121.1 - 0.038 14.4 3.5 0.038 14.4 3.5 1.5 1 1 0 1 1 1 0 Cysteine-rich domain zf-C3HC4_3 PF13920.6 AIF82121.1 - 0.3 11.0 11.9 0.79 9.6 12.0 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.16 AIF82121.1 - 1.8 8.8 9.2 3.4 7.9 9.2 1.6 1 1 0 1 1 1 0 FYVE-type zinc finger Sgf11 PF08209.11 AIF82121.1 - 2.1 8.0 9.0 3.8 7.2 0.2 3.2 2 1 1 3 3 3 0 Sgf11 (transcriptional regulation protein) DUF2797 PF10977.8 AIF82121.1 - 4.5 7.1 6.0 5.9 6.7 6.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2797) DUF4428 PF14471.6 AIF82121.1 - 9.4 6.3 11.9 17 5.5 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) Glyoxalase PF00903.25 AIF82122.1 - 1.6e-06 28.3 0.2 8.4e-06 26.0 0.2 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AIF82122.1 - 0.015 16.1 0.0 0.033 15.0 0.0 1.7 1 1 0 1 1 1 0 Glyoxalase-like domain UBA_6 PF18039.1 AIF82122.1 - 0.16 11.9 0.1 0.42 10.6 0.1 1.6 1 0 0 1 1 1 0 UBA-like domain N6_N4_Mtase PF01555.18 AIF82123.1 - 1.6e-22 80.3 0.2 9.7e-13 48.4 0.0 2.1 2 0 0 2 2 2 2 DNA methylase Dev_Cell_Death PF10539.9 AIF82123.1 - 1.5e-18 66.9 0.0 2.4e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Development and cell death domain Methyltransf_11 PF08241.12 AIF82123.1 - 4e-07 30.6 0.1 6.9e-06 26.6 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 AIF82123.1 - 1.5e-05 24.7 0.0 0.053 13.2 0.0 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_8 PF05148.15 AIF82123.1 - 0.00014 21.8 0.1 0.00045 20.1 0.0 1.8 2 0 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_25 PF13649.6 AIF82123.1 - 0.0017 19.0 0.1 0.03 15.0 0.1 2.9 1 1 0 1 1 1 1 Methyltransferase domain AviRa PF11599.8 AIF82123.1 - 0.13 11.6 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Methyltransf_23 PF13489.6 AIF82123.1 - 0.14 12.0 0.0 0.6 9.9 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Cons_hypoth95 PF03602.15 AIF82123.1 - 0.15 11.7 0.0 4 7.1 0.1 2.2 1 1 1 2 2 2 0 Conserved hypothetical protein 95 Neur_chan_memb PF02932.16 AIF82124.1 - 1e-06 29.0 3.5 1e-06 29.0 3.5 1.6 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region PalH PF08733.10 AIF82124.1 - 0.055 12.5 4.1 0.05 12.6 2.7 1.6 2 0 0 2 2 2 0 PalH/RIM21 DUF1195 PF06708.11 AIF82124.1 - 0.14 12.0 0.4 0.32 10.8 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) PhoU PF01895.19 AIF82125.1 - 6.1e-22 77.9 8.0 1.2e-16 60.9 1.7 2.9 2 0 0 2 2 2 2 PhoU domain MazE_antitoxin PF04014.18 AIF82125.1 - 6e-05 22.9 0.0 0.00019 21.3 0.0 1.9 2 0 0 2 2 2 1 Antidote-toxin recognition MazE, bacterial antitoxin PhoU PF01895.19 AIF82126.1 - 3.2e-33 114.0 2.3 1.5e-19 70.2 0.3 2.1 2 0 0 2 2 2 2 PhoU domain DUF2034 PF10356.9 AIF82126.1 - 0.018 14.5 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2034) Pil1 PF13805.6 AIF82126.1 - 0.021 14.3 0.6 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 Eisosome component PIL1 DUF1771 PF08590.10 AIF82126.1 - 0.029 14.7 0.4 0.19 12.1 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1771) Peptidase_M19 PF01244.21 AIF82126.1 - 0.036 13.2 0.2 0.097 11.8 0.0 1.7 2 0 0 2 2 2 0 Membrane dipeptidase (Peptidase family M19) Lectin_N PF03954.14 AIF82126.1 - 0.18 11.5 0.1 3.8 7.3 0.0 2.1 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain ABC_tran PF00005.27 AIF82127.1 - 1.9e-30 106.1 0.0 2.8e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIF82127.1 - 1.9e-10 41.0 0.3 0.00011 22.2 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIF82127.1 - 8.8e-10 38.4 0.2 5.2e-09 35.9 0.2 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 AIF82127.1 - 2.3e-05 24.7 0.0 9.5e-05 22.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 AIF82127.1 - 8.2e-05 22.5 0.0 0.00028 20.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 AIF82127.1 - 0.00025 21.0 0.1 0.00055 19.9 0.0 1.6 2 0 0 2 2 1 1 RsgA GTPase AAA PF00004.29 AIF82127.1 - 0.0003 21.2 0.4 0.0047 17.4 0.4 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 AIF82127.1 - 0.00095 19.1 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 AIF82127.1 - 0.0012 19.2 0.1 0.0026 18.2 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 AIF82127.1 - 0.0014 18.9 0.0 0.0032 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AIF82127.1 - 0.0015 18.3 0.4 0.021 14.6 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 AIF82127.1 - 0.0016 19.0 0.0 0.0033 18.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 AIF82127.1 - 0.0016 18.1 0.0 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 AIF82127.1 - 0.003 18.1 0.1 0.013 16.0 0.0 1.9 2 1 0 2 2 2 1 AAA domain TniB PF05621.11 AIF82127.1 - 0.005 16.3 0.1 1.3 8.4 0.0 2.1 2 0 0 2 2 2 1 Bacterial TniB protein ATPase_2 PF01637.18 AIF82127.1 - 0.0073 16.3 0.0 0.25 11.2 0.0 2.2 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_33 PF13671.6 AIF82127.1 - 0.015 15.4 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 AIF82127.1 - 0.021 14.9 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 AIF82127.1 - 0.028 14.2 0.1 0.057 13.2 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 AIF82127.1 - 0.035 13.8 0.2 0.11 12.2 0.0 1.9 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 AIF82127.1 - 0.035 13.6 0.1 0.063 12.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 AIF82127.1 - 0.04 13.1 0.0 0.055 12.6 0.0 1.4 1 1 0 1 1 1 0 NB-ARC domain ABC_ATPase PF09818.9 AIF82127.1 - 0.058 12.2 0.1 0.83 8.4 0.0 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class Viral_helicase1 PF01443.18 AIF82127.1 - 0.062 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 AIF82127.1 - 0.069 13.5 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 AIF82127.1 - 0.071 12.7 0.0 0.2 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 AIF82127.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 AIF82127.1 - 0.1 12.6 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 AIF82127.1 - 0.1 12.3 0.1 0.54 10.0 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 AIF82127.1 - 0.12 12.0 0.0 0.3 10.7 0.0 1.6 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Adeno_IVa2 PF02456.15 AIF82127.1 - 0.15 10.8 0.0 0.41 9.4 0.0 1.6 2 0 0 2 2 2 0 Adenovirus IVa2 protein cobW PF02492.19 AIF82127.1 - 0.16 11.5 0.4 0.39 10.3 0.1 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain BPD_transp_1 PF00528.22 AIF82128.1 - 8.4e-19 68.0 17.3 8.4e-19 68.0 17.3 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3333 PF11812.8 AIF82128.1 - 5.3e-05 23.5 2.5 0.0012 19.1 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3333) COX14 PF14880.6 AIF82128.1 - 0.0055 16.5 0.0 0.021 14.7 0.0 2.0 1 0 0 1 1 1 1 Cytochrome oxidase c assembly BPD_transp_1 PF00528.22 AIF82129.1 - 2.7e-16 59.8 20.6 2.7e-16 59.8 20.6 2.2 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component PBP_like_2 PF12849.7 AIF82130.1 - 1.2e-58 199.1 5.0 1.2e-58 199.1 5.0 1.7 2 0 0 2 2 2 1 PBP superfamily domain PBP_like PF12727.7 AIF82130.1 - 4e-10 39.1 0.0 1.8e-09 37.0 0.0 2.0 2 0 0 2 2 2 1 PBP superfamily domain Med12-PQL PF12144.8 AIF82130.1 - 0.037 13.9 1.2 0.06 13.2 1.2 1.3 1 0 0 1 1 1 0 Eukaryotic Mediator 12 catenin-binding domain His_Phos_1 PF00300.22 AIF82133.1 - 4.7e-13 49.3 0.0 9e-12 45.1 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Ppx-GppA PF02541.16 AIF82134.1 - 8.1e-51 173.1 0.0 1.4e-50 172.4 0.0 1.3 1 0 0 1 1 1 1 Ppx/GppA phosphatase family Thymidylate_kin PF02223.17 AIF82135.1 - 4.5e-22 78.6 0.0 7.6e-22 77.9 0.0 1.4 1 1 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 AIF82135.1 - 0.0021 18.6 0.1 0.014 15.9 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 AIF82135.1 - 0.016 15.5 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 AIF82135.1 - 0.022 14.6 0.1 0.11 12.4 0.1 2.0 1 1 0 1 1 1 0 Deoxynucleoside kinase AAA_17 PF13207.6 AIF82135.1 - 0.027 14.9 0.0 0.54 10.7 0.0 2.7 1 1 1 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 AIF82136.1 - 3e-20 72.7 0.0 4.3e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Thymidylate kinase AAA_17 PF13207.6 AIF82136.1 - 0.00062 20.2 0.0 0.0057 17.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain dNK PF01712.19 AIF82136.1 - 0.011 15.7 0.1 0.32 10.8 0.1 2.3 1 1 0 1 1 1 0 Deoxynucleoside kinase CHAD PF05235.14 AIF82137.1 - 4.4e-21 75.9 9.6 1.2e-19 71.2 8.3 1.8 1 1 1 2 2 2 2 CHAD domain RVT_3 PF13456.6 AIF82138.1 - 0.0023 17.8 0.1 0.0059 16.4 0.1 1.7 1 1 0 1 1 1 1 Reverse transcriptase-like DUF4817 PF16087.5 AIF82138.1 - 0.023 14.5 0.1 0.046 13.5 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) RT_RNaseH_2 PF17919.1 AIF82138.1 - 0.034 14.2 0.0 0.23 11.5 0.0 2.1 2 1 0 2 2 2 0 RNase H-like domain found in reverse transcriptase RNase_H PF00075.24 AIF82138.1 - 0.05 13.8 0.0 0.091 12.9 0.0 1.6 1 1 1 2 2 2 0 RNase H HxlR PF01638.17 AIF82139.1 - 3.6e-22 78.0 0.2 4.4e-22 77.7 0.2 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_34 PF13601.6 AIF82139.1 - 1.5e-05 25.1 0.0 2.1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain PadR PF03551.14 AIF82139.1 - 0.00036 20.4 0.2 0.00052 19.9 0.2 1.3 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family Replic_Relax PF13814.6 AIF82139.1 - 0.012 15.7 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 Replication-relaxation HTH_20 PF12840.7 AIF82139.1 - 0.033 14.3 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.6 AIF82139.1 - 0.066 12.8 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF2513 PF10711.9 AIF82139.1 - 0.16 12.3 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) Methyltransf_31 PF13847.6 AIF82140.1 - 6e-30 104.0 0.1 6e-30 104.0 0.1 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF82140.1 - 2.7e-20 72.9 2.4 3e-20 72.7 0.1 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF82140.1 - 2.9e-20 72.7 0.8 4.6e-20 72.1 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF82140.1 - 6.2e-14 51.9 0.4 1.1e-13 51.1 0.4 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 AIF82140.1 - 3.8e-10 40.4 0.7 7.1e-10 39.5 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain PCMT PF01135.19 AIF82140.1 - 1.2e-09 38.2 0.1 2.1e-09 37.5 0.1 1.4 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 AIF82140.1 - 8.1e-09 35.5 0.0 1.2e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 AIF82140.1 - 6.4e-08 32.3 0.2 8.7e-08 31.9 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 AIF82140.1 - 4.3e-06 26.2 0.0 5.6e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 AIF82140.1 - 3.8e-05 23.1 0.1 5.1e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_8 PF05148.15 AIF82140.1 - 4.2e-05 23.5 0.1 7.4e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_32 PF13679.6 AIF82140.1 - 0.00014 21.9 0.0 0.0002 21.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AIF82140.1 - 0.00015 21.4 0.0 0.00026 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 AIF82140.1 - 0.00016 21.4 0.0 0.00032 20.4 0.0 1.7 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 NNMT_PNMT_TEMT PF01234.17 AIF82140.1 - 0.003 16.8 0.0 0.54 9.4 0.0 2.1 2 0 0 2 2 2 1 NNMT/PNMT/TEMT family Methyltransf_15 PF09445.10 AIF82140.1 - 0.0044 16.6 0.0 0.0061 16.1 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase FtsJ PF01728.19 AIF82140.1 - 0.0045 17.1 0.0 0.0087 16.2 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase DOT1 PF08123.13 AIF82140.1 - 0.0097 15.4 0.2 0.019 14.5 0.2 1.5 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_24 PF13578.6 AIF82140.1 - 0.01 16.8 0.1 0.028 15.4 0.0 1.8 2 0 0 2 2 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 AIF82140.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 AIF82140.1 - 0.025 13.5 0.0 0.033 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) GARS_C PF02843.16 AIF82140.1 - 0.03 14.6 0.0 0.32 11.3 0.0 2.2 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, C domain ADH_zinc_N PF00107.26 AIF82140.1 - 0.056 13.4 0.1 0.14 12.1 0.1 1.7 1 1 0 1 1 1 0 Zinc-binding dehydrogenase GidB PF02527.15 AIF82140.1 - 0.18 11.1 0.6 1.6 8.0 0.4 2.2 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G LMWPc PF01451.21 AIF82141.1 - 3.6e-21 76.1 0.1 1.3e-20 74.3 0.1 1.7 1 1 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase MIP PF00230.20 AIF82142.1 - 5.1e-34 118.0 20.2 6.4e-34 117.6 20.2 1.0 1 0 0 1 1 1 1 Major intrinsic protein Na_H_Exchanger PF00999.21 AIF82143.1 - 7.4e-58 196.2 52.9 9.1e-58 195.9 52.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family SAM_4 PF18017.1 AIF82143.1 - 0.041 13.9 2.1 0.076 13.0 0.2 2.2 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Asp-Al_Ex PF06826.12 AIF82143.1 - 0.51 10.1 35.6 0.22 11.3 8.7 3.3 3 2 0 3 3 3 0 Predicted Permease Membrane Region SpoIIM PF01944.17 AIF82144.1 - 1.7e-07 31.4 6.9 2.3e-07 31.0 6.9 1.1 1 0 0 1 1 1 1 Stage II sporulation protein M ABM PF03992.16 AIF82145.1 - 5.6e-12 45.6 0.0 8.5e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase RNA12 PF10443.9 AIF82145.1 - 0.16 10.7 0.0 0.19 10.4 0.0 1.1 1 0 0 1 1 1 0 RNA12 protein Glycolipid_bind PF06475.11 AIF82148.1 - 1.4e-55 187.5 0.0 1.6e-55 187.3 0.0 1.0 1 0 0 1 1 1 1 Putative glycolipid-binding DUF1846 PF08903.11 AIF82148.1 - 0.26 9.8 0.0 0.33 9.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) zf-ribbon_3 PF13248.6 AIF82149.1 - 1.4e-05 24.3 3.8 1.9e-05 23.9 3.8 1.2 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_2 PF13240.6 AIF82149.1 - 1.5e-05 24.5 4.3 1.9e-05 24.2 4.3 1.2 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 AIF82149.1 - 3.6e-05 23.7 2.2 4.1e-05 23.5 2.2 1.1 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 AIF82149.1 - 0.00021 21.9 2.1 0.00022 21.9 2.1 1.0 1 0 0 1 1 1 1 zinc-ribbon family YhfH PF14149.6 AIF82149.1 - 0.0032 17.4 7.8 0.089 12.8 0.7 2.3 1 1 1 2 2 2 2 YhfH-like protein zf-C3HC4_3 PF13920.6 AIF82149.1 - 0.0064 16.3 1.8 0.0083 16.0 1.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rubredoxin_2 PF18073.1 AIF82149.1 - 0.024 14.4 2.2 0.034 13.9 2.2 1.3 1 0 0 1 1 1 0 Rubredoxin metal binding domain HypA PF01155.19 AIF82149.1 - 0.034 14.2 2.0 0.033 14.2 2.0 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_11 PF11682.8 AIF82149.1 - 0.036 14.1 0.6 0.036 14.1 0.6 1.1 1 0 0 1 1 1 0 Probable zinc-ribbon UPF0547 PF10571.9 AIF82149.1 - 0.041 14.0 4.5 0.058 13.5 4.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 DUF2321 PF10083.9 AIF82149.1 - 0.046 13.4 1.0 0.046 13.3 1.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Zn-ribbon_8 PF09723.10 AIF82149.1 - 0.072 13.2 6.2 1.8 8.7 0.2 2.1 1 1 1 2 2 2 0 Zinc ribbon domain zinc_ribbon_9 PF14369.6 AIF82149.1 - 0.099 12.9 2.8 2.2 8.6 0.5 2.1 1 1 1 2 2 2 0 zinc-ribbon zf-RRN7 PF11781.8 AIF82149.1 - 0.11 12.2 2.9 2.9 7.7 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Nudix_N_2 PF14803.6 AIF82149.1 - 0.17 11.8 5.1 13 5.8 4.9 2.2 1 1 0 1 1 1 0 Nudix N-terminal zf_UBZ PF18439.1 AIF82149.1 - 0.18 11.5 3.0 1.7 8.3 1.2 2.2 1 1 1 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF2256 PF10013.9 AIF82149.1 - 0.42 10.8 4.9 5.6 7.2 1.0 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) PAC2 PF09754.9 AIF82150.1 - 1.1e-27 97.5 0.0 1.2e-27 97.3 0.0 1.0 1 0 0 1 1 1 1 PAC2 family TP_methylase PF00590.20 AIF82151.1 - 1.7e-30 106.6 0.0 1.9e-30 106.4 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases AsnC_trans_reg PF01037.21 AIF82152.1 - 2.1e-11 43.6 0.2 2.1e-11 43.6 0.2 1.1 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain GYD PF08734.11 AIF82152.1 - 0.0049 16.8 0.0 0.0054 16.6 0.0 1.2 1 0 0 1 1 1 1 GYD domain Fer4 PF00037.27 AIF82154.1 - 6e-11 41.7 10.4 4.9e-07 29.3 0.7 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 AIF82154.1 - 3.9e-09 37.0 3.6 5e-09 36.6 3.6 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIF82154.1 - 1.4e-06 28.1 9.1 0.0012 18.8 0.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 AIF82154.1 - 2.3e-06 27.7 3.3 6.2e-06 26.3 3.4 1.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIF82154.1 - 2.9e-06 27.3 6.1 5.9e-06 26.3 6.1 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIF82154.1 - 1.6e-05 24.7 8.1 0.019 15.0 1.9 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 AIF82154.1 - 4.5e-05 23.9 4.5 0.06 13.9 0.5 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_16 PF13484.6 AIF82154.1 - 0.00015 22.6 5.9 0.072 14.0 0.2 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 AIF82154.1 - 0.00027 21.0 9.0 0.011 15.8 9.7 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 AIF82154.1 - 0.00048 20.4 6.7 0.17 12.5 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_22 PF17179.4 AIF82154.1 - 0.0015 19.3 2.3 0.5 11.3 0.5 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIF82154.1 - 0.0017 18.8 5.3 0.016 15.6 5.4 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIF82154.1 - 0.0037 18.1 12.1 0.28 12.2 4.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 AIF82154.1 - 0.043 14.6 10.4 0.31 11.8 1.9 2.8 1 1 1 2 2 2 0 4Fe-4S single cluster domain Fer4_17 PF13534.6 AIF82154.1 - 0.054 14.0 7.5 2.4 8.8 7.5 2.1 1 1 0 1 1 1 0 4Fe-4S dicluster domain AFP PF02420.15 AIF82154.1 - 0.15 12.4 0.4 0.15 12.4 0.4 2.4 3 0 0 3 3 2 0 Insect antifreeze protein repeat Fer4_18 PF13746.6 AIF82154.1 - 0.77 10.0 10.3 1.9 8.7 3.0 2.1 1 1 0 2 2 2 0 4Fe-4S dicluster domain DUF1743 PF08489.11 AIF82155.1 - 3.1e-37 127.2 0.0 5.5e-37 126.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1743) C1_2 PF03107.16 AIF82155.1 - 0.016 15.5 0.2 0.038 14.3 0.2 1.6 1 0 0 1 1 1 0 C1 domain Zn_ribbon_recom PF13408.6 AIF82155.1 - 0.076 13.5 2.7 0.25 11.9 2.7 1.9 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain C1_1 PF00130.22 AIF82155.1 - 0.11 12.3 3.2 0.17 11.8 2.0 1.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) OrfB_Zn_ribbon PF07282.11 AIF82155.1 - 0.21 11.5 3.4 0.12 12.3 0.9 1.9 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Dockerin_1 PF00404.18 AIF82156.1 - 0.19 12.0 0.0 0.28 11.4 0.0 1.3 1 1 0 1 1 1 0 Dockerin type I domain RBM39linker PF15519.6 AIF82158.1 - 0.025 15.7 0.2 0.029 15.5 0.2 1.0 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein LapA_dom PF06305.11 AIF82158.1 - 1.3 8.9 4.4 1.5 8.7 4.4 1.1 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain PRA-CH PF01502.18 AIF82159.1 - 1.8e-32 111.0 0.1 2.2e-32 110.7 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PALP PF00291.25 AIF82160.1 - 3.5e-70 236.7 0.7 4.1e-70 236.5 0.7 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme NinF PF05810.12 AIF82160.1 - 0.013 15.3 0.2 0.034 14.0 0.2 1.6 1 0 0 1 1 1 0 NinF protein C1_2 PF03107.16 AIF82160.1 - 0.15 12.4 1.2 0.26 11.6 1.2 1.4 1 0 0 1 1 1 0 C1 domain HypA PF01155.19 AIF82160.1 - 0.17 11.9 0.6 0.33 11.0 0.6 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_2 PF13240.6 AIF82160.1 - 2.3 8.1 5.8 4 7.3 5.8 1.4 1 0 0 1 1 1 0 zinc-ribbon domain ThiF PF00899.21 AIF82161.1 - 8.6e-70 234.9 0.1 1.2e-69 234.3 0.1 1.1 1 0 0 1 1 1 1 ThiF family ThiS PF02597.20 AIF82161.1 - 1.6e-09 38.2 0.0 5.5e-09 36.5 0.0 1.9 2 0 0 2 2 2 1 ThiS family Shikimate_DH PF01488.20 AIF82161.1 - 2e-05 24.7 0.1 4.6e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 AIF82161.1 - 6.7e-05 23.1 0.9 0.00027 21.2 0.8 2.0 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 AIF82161.1 - 0.0044 17.4 0.2 0.011 16.2 0.2 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 AIF82161.1 - 0.016 14.5 0.1 0.029 13.7 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TBP PF00352.21 AIF82161.1 - 0.018 15.0 0.0 0.13 12.2 0.0 2.3 2 0 0 2 2 2 0 Transcription factor TFIID (or TATA-binding protein, TBP) UDPG_MGDP_dh_N PF03721.14 AIF82161.1 - 0.02 14.5 0.3 0.048 13.2 0.3 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Wzt_C PF14524.6 AIF82162.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Wzt C-terminal domain SDA1 PF05285.12 AIF82162.1 - 1.9 7.8 13.0 2.4 7.5 13.0 1.2 1 0 0 1 1 1 0 SDA1 RAP1 PF07218.11 AIF82162.1 - 2.1 6.5 13.7 2.7 6.2 13.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Presenilin PF01080.17 AIF82162.1 - 2.5 6.8 7.0 2.8 6.6 7.0 1.1 1 0 0 1 1 1 0 Presenilin PNISR PF15996.5 AIF82162.1 - 7.6 6.8 11.4 11 6.2 11.4 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR PolC_DP2 PF03833.13 AIF82163.1 - 0 1035.6 0.1 0 1033.6 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase II large subunit DP2 zinc-ribbons_6 PF07191.12 AIF82163.1 - 0.053 13.5 18.5 0.29 11.1 0.3 3.1 2 1 0 2 2 2 0 zinc-ribbons HypA PF01155.19 AIF82163.1 - 0.33 11.0 14.5 0.79 9.8 0.1 3.9 3 1 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 AIF82163.1 - 1.1 9.4 19.9 1.4 9.0 0.8 3.2 2 1 0 2 2 2 0 Double zinc ribbon HNH_5 PF14279.6 AIF82163.1 - 2.4 8.1 5.8 1.4 8.9 0.0 3.2 2 1 1 3 3 3 0 HNH endonuclease zf-CHY PF05495.12 AIF82163.1 - 7.2 7.2 13.4 24 5.5 0.3 2.6 2 0 0 2 2 2 0 CHY zinc finger PcrB PF01884.17 AIF82164.1 - 9.6e-54 182.2 0.5 1.2e-53 181.9 0.5 1.0 1 0 0 1 1 1 1 PcrB family His_biosynth PF00977.21 AIF82164.1 - 3.5e-08 33.2 0.2 3.4e-07 30.0 0.0 2.1 2 0 0 2 2 2 1 Histidine biosynthesis protein IMPDH PF00478.25 AIF82164.1 - 8.7e-06 25.0 3.0 6e-05 22.2 3.0 1.9 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Trp_syntA PF00290.20 AIF82164.1 - 6.9e-05 21.8 1.2 0.00032 19.6 0.2 2.0 2 0 0 2 2 2 1 Tryptophan synthase alpha chain Glyco_tran_WecB PF03808.13 AIF82164.1 - 0.00042 20.3 0.1 0.0086 16.0 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase WecB/TagA/CpsF family B12-binding PF02310.19 AIF82164.1 - 0.0008 19.4 2.7 0.32 11.1 0.2 3.7 3 1 1 4 4 4 1 B12 binding domain ThiG PF05690.14 AIF82164.1 - 0.00085 18.7 1.5 0.063 12.6 0.2 2.1 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG NanE PF04131.14 AIF82164.1 - 0.00091 18.5 1.7 0.0044 16.2 0.1 2.3 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase Ribul_P_3_epim PF00834.19 AIF82164.1 - 0.0025 17.3 0.3 0.0049 16.3 0.3 1.5 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family TMP-TENI PF02581.17 AIF82164.1 - 0.0052 16.1 0.1 0.026 13.9 0.0 1.9 2 0 0 2 2 2 1 Thiamine monophosphate synthase IGPS PF00218.21 AIF82164.1 - 0.011 14.9 0.2 0.2 10.8 0.0 2.1 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase FMN_dh PF01070.18 AIF82164.1 - 0.018 14.1 0.1 0.13 11.2 0.0 2.0 2 0 0 2 2 2 0 FMN-dependent dehydrogenase DHO_dh PF01180.21 AIF82164.1 - 0.022 14.0 0.6 0.022 14.0 0.6 1.8 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase Dus PF01207.17 AIF82164.1 - 0.029 13.5 0.4 2.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) OMPdecase PF00215.24 AIF82164.1 - 0.06 12.9 0.2 0.16 11.5 0.1 1.8 2 0 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Matrix PF00661.21 AIF82164.1 - 0.071 11.8 0.0 0.096 11.4 0.0 1.2 1 0 0 1 1 1 0 Viral matrix protein DpaA_N PF16924.5 AIF82164.1 - 0.094 12.8 0.3 2.7 8.1 0.1 2.7 3 0 0 3 3 3 0 Dipicolinate synthase subunit A N-terminal domain PA PF02225.22 AIF82164.1 - 0.28 11.2 0.1 0.28 11.2 0.1 2.1 3 0 0 3 3 3 0 PA domain TrmB PF01978.19 AIF82166.1 - 0.00014 21.7 0.0 0.00031 20.5 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Replic_Relax PF13814.6 AIF82166.1 - 0.00039 20.6 0.5 0.00069 19.7 0.5 1.4 1 0 0 1 1 1 1 Replication-relaxation HTH_27 PF13463.6 AIF82166.1 - 0.00043 20.7 0.1 0.00097 19.6 0.1 1.6 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_Crp_2 PF13545.6 AIF82166.1 - 0.014 15.3 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_20 PF12840.7 AIF82166.1 - 0.045 13.8 0.1 0.091 12.8 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HxlR PF01638.17 AIF82166.1 - 0.074 12.9 0.6 0.14 12.0 0.2 1.6 2 0 0 2 2 2 0 HxlR-like helix-turn-helix Serine_rich PF08824.10 AIF82166.1 - 0.074 13.0 0.1 0.57 10.2 0.0 1.9 2 0 0 2 2 2 0 Serine rich protein interaction domain Crp PF00325.20 AIF82166.1 - 0.1 12.2 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family PKcGMP_CC PF16808.5 AIF82166.1 - 0.25 11.2 0.9 0.41 10.5 0.1 1.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Penicillinase_R PF03965.16 AIF82167.1 - 0.15 12.4 0.0 0.24 11.8 0.0 1.3 1 0 0 1 1 1 0 Penicillinase repressor HTH_ABP1_N PF18107.1 AIF82167.1 - 0.18 11.5 0.1 0.18 11.5 0.1 1.6 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain Cdc6_C PF09079.11 AIF82168.1 - 7.9e-20 70.6 0.1 2.4e-19 69.1 0.1 1.8 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA PF00004.29 AIF82168.1 - 5.6e-13 49.5 2.1 1.2e-12 48.4 0.1 2.5 3 1 1 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AIF82168.1 - 2.8e-11 44.1 2.1 2e-10 41.3 0.1 2.9 2 2 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AIF82168.1 - 1.5e-10 41.4 0.1 6.2e-10 39.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 AIF82168.1 - 2.3e-07 30.4 0.0 5.4e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_19 PF13245.6 AIF82168.1 - 9.1e-06 26.1 0.7 4.3e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 AIF82168.1 - 1.2e-05 24.6 0.2 4.2e-05 22.8 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF815) ATPase_2 PF01637.18 AIF82168.1 - 1.7e-05 24.9 1.6 2.3e-05 24.4 0.1 2.0 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea NACHT PF05729.12 AIF82168.1 - 0.00018 21.5 1.8 0.0014 18.6 0.2 2.7 2 1 0 2 2 2 1 NACHT domain DUF2075 PF09848.9 AIF82168.1 - 0.0014 18.0 0.6 0.0026 17.1 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Zeta_toxin PF06414.12 AIF82168.1 - 0.0022 17.3 0.1 0.011 15.0 0.1 2.1 1 1 0 1 1 1 1 Zeta toxin NB-ARC PF00931.22 AIF82168.1 - 0.0023 17.2 0.1 0.0044 16.2 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain ResIII PF04851.15 AIF82168.1 - 0.0029 17.6 0.7 0.011 15.8 0.0 2.1 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Sigma54_activat PF00158.26 AIF82168.1 - 0.0034 17.1 0.0 0.0097 15.6 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 AIF82168.1 - 0.0038 17.2 0.6 0.025 14.6 0.3 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) KAP_NTPase PF07693.14 AIF82168.1 - 0.0039 16.5 0.6 0.1 11.9 0.0 2.4 1 1 1 2 2 2 1 KAP family P-loop domain AAA_7 PF12775.7 AIF82168.1 - 0.0096 15.5 0.0 0.023 14.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 AIF82168.1 - 0.011 15.9 0.2 0.043 14.0 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA_assoc_2 PF16193.5 AIF82168.1 - 0.011 16.0 2.0 0.05 13.9 2.0 2.2 1 1 0 1 1 1 0 AAA C-terminal domain AAA_30 PF13604.6 AIF82168.1 - 0.012 15.3 0.3 0.039 13.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 AIF82168.1 - 0.018 15.5 2.6 0.27 11.7 0.2 2.9 2 2 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 AIF82168.1 - 0.02 14.6 0.3 0.083 12.6 0.3 2.0 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 AIF82168.1 - 0.03 14.1 1.3 0.12 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 AIF82168.1 - 0.035 14.0 1.8 0.21 11.5 1.8 2.2 1 1 0 1 1 1 0 NTPase ATPase PF06745.13 AIF82168.1 - 0.038 13.3 0.4 0.23 10.8 0.4 2.2 1 1 0 1 1 1 0 KaiC TsaE PF02367.17 AIF82168.1 - 0.051 13.6 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_lid_10 PF17872.1 AIF82168.1 - 0.064 13.4 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 AAA lid domain Helicase_RecD PF05127.14 AIF82168.1 - 0.066 13.1 0.3 0.16 11.8 0.0 1.7 2 0 0 2 2 2 0 Helicase RuvB_N PF05496.12 AIF82168.1 - 0.067 12.9 0.7 3.5 7.3 0.0 2.6 1 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain MMR_HSR1 PF01926.23 AIF82168.1 - 0.13 12.4 0.8 0.23 11.5 0.1 1.9 2 0 0 2 2 1 0 50S ribosome-binding GTPase DNA_pol_E_B PF04042.16 AIF82169.1 - 3.2e-20 72.4 0.0 1.2e-19 70.6 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B Metallophos_2 PF12850.7 AIF82169.1 - 3.7e-09 37.0 0.0 1.6e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 AIF82169.1 - 4.4e-09 37.1 0.0 7.3e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase tRNA_anti-codon PF01336.25 AIF82169.1 - 1.6e-05 24.8 0.0 2.9e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF2415 PF10313.9 AIF82169.1 - 0.11 12.4 0.1 0.22 11.5 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) HTH_24 PF13412.6 AIF82171.1 - 3.4e-05 23.3 0.6 8e-05 22.1 0.6 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF82171.1 - 0.00045 20.0 0.3 0.00086 19.1 0.3 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.12 AIF82171.1 - 0.0019 18.1 0.1 0.0053 16.7 0.1 1.7 1 0 0 1 1 1 1 HTH domain HTH_23 PF13384.6 AIF82171.1 - 0.035 13.9 0.0 0.14 12.0 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain HTH_8 PF02954.19 AIF82171.1 - 0.054 13.3 0.5 1.1 9.2 0.1 2.6 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family zf_UBZ PF18439.1 AIF82172.1 - 0.00041 19.9 2.7 0.086 12.5 0.3 2.1 1 1 1 2 2 2 2 Ubiquitin-Binding Zinc Finger DZR PF12773.7 AIF82172.1 - 0.00055 19.9 0.7 0.00063 19.7 0.7 1.1 1 0 0 1 1 1 1 Double zinc ribbon DNA_RNApol_7kD PF03604.13 AIF82172.1 - 0.0011 18.6 0.7 0.14 11.9 0.1 2.1 2 0 0 2 2 2 2 DNA directed RNA polymerase, 7 kDa subunit C1_1 PF00130.22 AIF82172.1 - 0.013 15.3 1.7 0.019 14.9 1.7 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) COX15-CtaA PF02628.15 AIF82173.1 - 6e-10 38.7 15.9 1.2e-07 31.2 10.4 2.1 1 1 1 2 2 2 2 Cytochrome oxidase assembly protein SpecificRecomb PF10136.9 AIF82173.1 - 0.015 13.7 1.7 0.018 13.4 1.7 1.1 1 0 0 1 1 1 0 Site-specific recombinase DUF2070 PF09843.9 AIF82173.1 - 0.81 7.9 5.6 1.1 7.5 5.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MPS-4 PF17523.2 AIF82173.1 - 2.1 8.5 4.8 0.32 11.1 0.5 1.8 2 0 0 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 Response_reg PF00072.24 AIF82174.1 - 7.1e-14 51.9 0.1 7.6e-14 51.8 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain Guanylate_cyc PF00211.20 AIF82176.1 - 5.8e-15 55.4 0.0 1.2e-14 54.3 0.0 1.5 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HTH_29 PF13551.6 AIF82176.1 - 0.00078 19.4 0.0 0.0081 16.2 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 AIF82176.1 - 0.02 14.7 0.0 0.24 11.3 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain RNA_polI_A14 PF08203.11 AIF82176.1 - 0.064 14.0 0.8 1.3 9.8 0.1 2.3 1 1 1 2 2 2 0 Yeast RNA polymerase I subunit RPA14 PG_binding_4 PF12229.8 AIF82176.1 - 0.071 13.4 0.2 2.4 8.5 0.1 2.6 2 1 1 3 3 3 0 Putative peptidoglycan binding domain PAX PF00292.18 AIF82176.1 - 0.18 11.8 0.0 0.4 10.6 0.0 1.6 1 0 0 1 1 1 0 'Paired box' domain CytB6-F_Fe-S PF08802.10 AIF82178.1 - 0.086 12.9 0.2 0.15 12.1 0.2 1.3 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit TFIIE_alpha PF02002.17 AIF82179.1 - 4.8e-19 68.1 3.4 4.9e-19 68.1 1.0 1.9 2 0 0 2 2 2 1 TFIIE alpha subunit zf_CopZ PF18423.1 AIF82179.1 - 0.0097 15.8 2.3 1.4 8.9 0.3 2.4 1 1 1 2 2 2 2 Zinc binding domain DUF4611 PF15387.6 AIF82179.1 - 0.039 14.2 5.9 0.089 13.0 5.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Paf1 PF03985.13 AIF82179.1 - 0.045 12.7 9.3 0.064 12.2 9.3 1.2 1 0 0 1 1 1 0 Paf1 FucT_N PF18025.1 AIF82179.1 - 0.071 13.6 0.1 0.14 12.7 0.1 1.4 1 0 0 1 1 1 0 Alpha-(1,3)-fucosyltransferase FucT N-terminal domain Sushi_2 PF09014.10 AIF82179.1 - 0.12 12.3 1.0 0.22 11.4 1.0 1.4 1 0 0 1 1 1 0 Beta-2-glycoprotein-1 fifth domain HTH_9 PF08221.11 AIF82179.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Menin PF05053.13 AIF82179.1 - 0.29 9.5 11.7 0.39 9.0 11.7 1.1 1 0 0 1 1 1 0 Menin GEN1_C PF18380.1 AIF82179.1 - 0.4 11.6 6.1 0.84 10.6 6.1 1.6 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain Rad50_zn_hook PF04423.14 AIF82179.1 - 0.43 10.4 0.0 0.43 10.4 0.0 2.8 2 1 0 3 3 3 0 Rad50 zinc hook motif CDC45 PF02724.14 AIF82179.1 - 0.49 8.6 6.6 0.52 8.5 6.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2052 PF09747.9 AIF82179.1 - 0.67 10.1 9.0 0.14 12.3 6.0 1.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) RNA_pol_Rpc4 PF05132.14 AIF82179.1 - 0.73 10.2 8.8 1.1 9.7 8.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 CPSF100_C PF13299.6 AIF82179.1 - 3.4 7.8 9.7 6.9 6.8 9.7 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 AIF82179.1 - 3.6 7.3 11.2 5.4 6.8 11.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 AIF82179.1 - 7.5 5.2 8.3 9.2 4.9 8.3 1.1 1 0 0 1 1 1 0 Presenilin Peptidase_S30 PF01577.16 AIF82179.1 - 9.6 5.7 13.6 23 4.5 0.2 2.1 1 1 1 2 2 2 0 Potyvirus P1 protease HTH_3 PF01381.22 AIF82180.1 - 3e-08 33.6 0.0 4.3e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 AIF82180.1 - 5.3e-07 29.9 0.0 8.7e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 AIF82180.1 - 6e-07 29.4 0.0 8.5e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain MerR_1 PF13411.6 AIF82180.1 - 0.081 13.0 0.0 5.3 7.2 0.0 2.3 1 1 1 2 2 2 0 MerR HTH family regulatory protein DUF3606 PF12244.8 AIF82180.1 - 0.096 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) Tautomerase PF01361.21 AIF82181.1 - 3.7e-14 52.4 0.1 3.9e-14 52.3 0.1 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_2 PF14552.6 AIF82181.1 - 1.5e-07 31.4 0.0 1.7e-07 31.2 0.0 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_3 PF14832.6 AIF82181.1 - 0.024 14.9 0.0 0.024 14.8 0.0 1.0 1 0 0 1 1 1 0 Putative oxalocrotonate tautomerase enzyme Ketoacyl-synt_2 PF13723.6 AIF82181.1 - 0.035 13.7 0.0 0.04 13.5 0.0 1.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain CN_hydrolase PF00795.22 AIF82182.1 - 6.2e-50 170.0 0.0 6.9e-50 169.8 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase bPH_3 PF14470.6 AIF82183.1 - 3.1e-15 56.3 0.0 1.2e-13 51.3 0.0 2.2 1 1 0 1 1 1 1 Bacterial PH domain SHOCT PF09851.9 AIF82183.1 - 8.3e-08 31.7 1.3 8.3e-08 31.7 1.3 2.1 2 0 0 2 2 2 1 Short C-terminal domain bPH_2 PF03703.14 AIF82183.1 - 0.053 13.7 0.6 0.18 12.0 0.6 1.9 1 1 0 1 1 1 0 Bacterial PH domain Peripla_BP_1 PF00532.21 AIF82183.1 - 0.064 12.7 0.1 0.089 12.2 0.1 1.2 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family tRNA-synt_1f PF01921.18 AIF82184.1 - 0.036 13.0 0.0 0.037 12.9 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (K) Topoisom_bac PF01131.20 AIF82185.1 - 1.7e-111 373.2 0.0 2e-111 372.9 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 AIF82185.1 - 5.8e-13 48.9 0.0 2.2e-12 47.1 0.0 2.0 3 0 0 3 3 3 1 Toprim domain zf-C4_Topoisom PF01396.19 AIF82185.1 - 0.00029 20.6 0.9 0.00059 19.6 0.9 1.6 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger DUF2367 PF10164.9 AIF82185.1 - 0.032 14.7 0.1 0.071 13.6 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) Thiolase_N PF00108.23 AIF82186.1 - 7.8e-24 84.4 0.2 1.8e-23 83.3 0.2 1.6 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AIF82186.1 - 2.6e-13 49.7 0.9 1.7e-09 37.4 0.0 3.4 2 2 1 3 3 3 2 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 AIF82186.1 - 1.9e-05 24.4 2.2 0.018 14.7 0.6 2.6 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 AIF82186.1 - 0.0037 17.3 0.7 0.34 10.9 0.1 3.3 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain OB_aCoA_assoc PF01796.17 AIF82187.1 - 4.7e-06 26.5 0.1 7.1e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 DUF35 OB-fold domain, acyl-CoA-associated zinc_ribbon_2 PF13240.6 AIF82187.1 - 0.00011 21.8 0.5 0.00019 21.0 0.5 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DUF35_N PF12172.8 AIF82187.1 - 0.0038 17.1 0.1 0.006 16.4 0.1 1.3 1 0 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc_ribbon_15 PF17032.5 AIF82187.1 - 0.016 15.9 0.7 0.023 15.4 0.7 1.2 1 0 0 1 1 1 0 zinc-ribbon family DZR PF12773.7 AIF82187.1 - 0.025 14.6 0.5 0.039 14.0 0.5 1.2 1 0 0 1 1 1 0 Double zinc ribbon MTHFR_C PF12225.8 AIF82187.1 - 0.034 13.8 0.5 0.047 13.3 0.5 1.2 1 0 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal TackOD1 PF18551.1 AIF82187.1 - 0.034 13.8 0.7 0.045 13.4 0.7 1.1 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 zinc_ribbon_13 PF09855.9 AIF82187.1 - 0.12 12.6 1.7 8.1 6.7 0.1 2.3 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) CENP-F_leu_zip PF10473.9 AIF82188.1 - 0.00028 20.9 6.2 0.012 15.7 2.1 2.1 2 0 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FapA PF03961.13 AIF82188.1 - 0.0063 15.2 2.6 0.0076 14.9 2.6 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF3450 PF11932.8 AIF82188.1 - 0.022 14.1 4.3 0.027 13.8 1.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Neprosin_AP PF14365.6 AIF82188.1 - 0.039 14.4 0.0 0.057 13.9 0.0 1.3 1 0 0 1 1 1 0 Neprosin activation peptide DUF2951 PF11166.8 AIF82188.1 - 0.041 14.1 4.0 0.11 12.7 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) CC2-LZ PF16516.5 AIF82188.1 - 0.043 14.2 4.1 0.88 10.0 0.1 2.2 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator BST2 PF16716.5 AIF82188.1 - 0.19 12.3 3.8 0.21 12.2 1.3 2.0 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Seryl_tRNA_N PF02403.22 AIF82188.1 - 0.55 10.5 6.6 1.6 9.0 6.6 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain JIP_LZII PF16471.5 AIF82188.1 - 0.89 9.8 10.9 0.46 10.7 3.4 2.5 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II zf-RRN7 PF11781.8 AIF82189.1 - 8.2e-05 22.2 0.5 0.28 10.9 0.1 2.1 2 0 0 2 2 2 2 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TF_Zn_Ribbon PF08271.12 AIF82189.1 - 0.00019 20.8 3.8 0.017 14.7 0.5 2.1 1 1 1 2 2 2 2 TFIIB zinc-binding zf-ribbon_3 PF13248.6 AIF82189.1 - 0.00034 19.9 2.5 0.31 10.5 0.3 2.2 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 AIF82189.1 - 0.0012 18.8 0.3 0.0016 18.4 0.3 1.3 1 1 0 1 1 1 1 Double zinc ribbon zf-NADH-PPase PF09297.11 AIF82189.1 - 0.0013 18.4 1.2 0.28 10.9 0.1 2.2 2 0 0 2 2 2 2 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 AIF82189.1 - 0.0022 17.6 0.7 0.49 10.2 0.1 2.1 2 0 0 2 2 2 1 zinc-ribbon domain Prok-RING_1 PF14446.6 AIF82189.1 - 0.0031 17.4 0.6 0.39 10.7 0.0 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-ACC PF17848.1 AIF82189.1 - 0.0032 17.5 0.2 0.68 10.1 0.1 2.2 2 0 0 2 2 2 1 Acetyl-coA carboxylase zinc finger domain Rtf2 PF04641.12 AIF82189.1 - 0.011 15.2 0.3 0.012 15.0 0.3 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Zn-ribbon_8 PF09723.10 AIF82189.1 - 0.011 15.8 0.8 0.036 14.2 0.8 1.7 1 1 0 1 1 1 0 Zinc ribbon domain Rad50_zn_hook PF04423.14 AIF82189.1 - 0.011 15.5 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif ADK_lid PF05191.14 AIF82189.1 - 0.012 15.6 0.3 0.018 15.0 0.3 1.3 1 0 0 1 1 1 0 Adenylate kinase, active site lid zf-C2HC5 PF06221.13 AIF82189.1 - 0.02 14.9 0.5 0.045 13.7 0.5 1.6 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type Zn_ribbon_recom PF13408.6 AIF82189.1 - 0.022 15.2 0.3 1.6 9.3 0.1 2.1 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zinc_ribbon_15 PF17032.5 AIF82189.1 - 0.051 14.3 0.1 0.059 14.1 0.1 1.1 1 0 0 1 1 1 0 zinc-ribbon family zinc_ribbon_5 PF13719.6 AIF82189.1 - 0.055 13.2 1.2 1.1 9.1 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Ribosomal_S27 PF01599.19 AIF82189.1 - 0.063 13.4 1.3 5 7.4 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein S27a zf_UBZ PF18439.1 AIF82189.1 - 0.1 12.2 0.1 4.3 7.0 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Nudix_N_2 PF14803.6 AIF82189.1 - 0.11 12.5 4.3 2.5 8.1 0.9 2.2 2 0 0 2 2 2 0 Nudix N-terminal DUF35_N PF12172.8 AIF82189.1 - 0.13 12.2 1.5 12 5.8 0.1 2.1 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Nop10p PF04135.12 AIF82189.1 - 0.13 12.3 1.3 5.7 7.1 1.3 2.1 1 1 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family zf-C2H2_12 PF18658.1 AIF82189.1 - 0.42 10.2 1.6 7.8 6.2 0.3 2.0 1 1 1 2 2 2 0 Zinc-finger C2H2-type Zn_Tnp_IS1595 PF12760.7 AIF82189.1 - 0.46 10.5 2.9 5.4 7.1 0.3 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Snf7 PF03357.21 AIF82190.1 - 1.7e-05 24.5 3.2 4.4e-05 23.1 3.2 1.7 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 AIF82190.1 - 0.01 15.7 0.4 0.018 15.0 0.1 1.5 2 0 0 2 2 2 0 Regulator of Vps4 activity in the MVB pathway DASH_Dad2 PF08654.10 AIF82190.1 - 6.8 7.2 9.6 46 4.5 5.7 3.2 2 1 0 2 2 2 0 DASH complex subunit Dad2 NRDD PF13597.6 AIF82191.1 - 3.1e-19 69.2 0.0 1.1e-14 54.2 0.0 2.3 2 0 0 2 2 2 2 Anaerobic ribonucleoside-triphosphate reductase HTH_20 PF12840.7 AIF82191.1 - 1.3e-09 38.0 0.1 4.9e-09 36.1 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain ATP-cone PF03477.16 AIF82191.1 - 1.9e-09 38.0 0.2 5.5e-09 36.5 0.2 1.8 1 0 0 1 1 1 1 ATP cone domain Flu_NP PF00506.18 AIF82191.1 - 0.0016 17.2 0.2 0.0038 16.0 0.0 1.6 2 0 0 2 2 2 1 Influenza virus nucleoprotein ZT_dimer PF16916.5 AIF82191.1 - 0.028 14.6 0.0 0.073 13.2 0.0 1.7 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter Lig_C PF18330.1 AIF82191.1 - 0.038 14.0 0.1 2.2 8.3 0.0 2.5 2 0 0 2 2 2 0 Ligase Pab1020 C-terminal region MnmE_helical PF12631.7 AIF82191.1 - 0.047 13.9 0.0 0.35 11.0 0.2 2.1 2 1 1 3 3 3 0 MnmE helical domain LytR_C PF13399.6 AIF82191.1 - 0.49 11.4 4.0 0.61 11.1 1.5 2.4 2 0 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator Ribonuc_red_lgC PF02867.15 AIF82192.1 - 5.5e-188 625.8 0.0 9.2e-188 625.0 0.0 1.4 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 AIF82192.1 - 2.2e-31 107.7 0.1 9.5e-31 105.7 0.1 2.2 1 1 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 AIF82192.1 - 1e-17 64.5 0.3 4e-17 62.6 0.3 2.2 1 0 0 1 1 1 1 ATP cone domain zf-ribbon_3 PF13248.6 AIF82192.1 - 0.073 12.5 3.4 0.16 11.4 3.4 1.6 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.7 AIF82192.1 - 0.11 12.5 1.6 0.2 11.7 1.6 1.3 1 0 0 1 1 1 0 Double zinc ribbon adh_short PF00106.25 AIF82193.1 - 9.4e-34 116.6 0.2 1e-32 113.2 0.2 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIF82193.1 - 1.3e-25 90.4 0.4 9.1e-25 87.6 0.4 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIF82193.1 - 1.2e-08 35.1 0.3 2.2e-08 34.2 0.3 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AIF82193.1 - 0.0006 19.3 0.0 0.00097 18.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 AIF82193.1 - 0.013 14.6 0.1 0.024 13.8 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 AIF82193.1 - 0.031 14.2 0.1 0.057 13.3 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 AIF82193.1 - 0.071 13.3 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase AP_endonuc_2 PF01261.24 AIF82197.1 - 0.013 15.0 0.0 0.03 13.8 0.0 1.7 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel Methyltrans_RNA PF04452.14 AIF82197.1 - 0.023 14.0 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 RNA methyltransferase NAD_synthase PF02540.17 AIF82198.1 - 6.8e-78 261.1 0.0 7.8e-78 260.9 0.0 1.0 1 0 0 1 1 1 1 NAD synthase tRNA_Me_trans PF03054.16 AIF82198.1 - 5e-06 25.5 0.0 0.00014 20.8 0.0 2.3 2 0 0 2 2 2 1 tRNA methyl transferase Asn_synthase PF00733.21 AIF82198.1 - 2.5e-05 24.1 0.0 4.9e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.13 AIF82198.1 - 0.0013 18.3 0.0 0.0027 17.2 0.0 1.5 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Rieske PF00355.26 AIF82200.1 - 3.1e-15 55.9 0.2 3.5e-15 55.7 0.2 1.2 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIF82200.1 - 0.00046 20.1 0.0 0.00061 19.7 0.0 1.2 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain FG-GAP PF01839.23 AIF82200.1 - 0.54 10.4 5.8 2.8 8.2 0.1 2.8 3 0 0 3 3 3 0 FG-GAP repeat Ferritin PF00210.24 AIF82201.1 - 6.1e-23 81.3 0.0 7.6e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Ferritin-like domain Ferritin_2 PF13668.6 AIF82201.1 - 0.086 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Ferritin-like domain COQ7 PF03232.13 AIF82201.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 2 0 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 HTH_45 PF14947.6 AIF82202.1 - 1.3e-14 53.9 0.0 1.6e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix Peptidase_M48 PF01435.18 AIF82203.1 - 1.1e-38 133.0 0.1 9.2e-38 130.0 0.1 2.0 1 1 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 AIF82203.1 - 5.1e-09 35.7 0.4 6.3e-08 32.2 0.0 2.0 2 0 0 2 2 2 1 BlaR1 peptidase M56 DUF4853 PF16145.5 AIF82203.1 - 0.015 15.4 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) MLANA PF14991.6 AIF82203.1 - 0.025 14.9 0.0 2.1 8.6 0.0 2.4 2 0 0 2 2 2 0 Protein melan-A DUF4157 PF13699.6 AIF82203.1 - 0.14 12.4 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4157) Phage_holin_3_6 PF07332.11 AIF82203.1 - 4 7.5 10.8 9.6 6.3 1.2 2.6 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Tetraspanin PF00335.20 AIF82204.1 - 3.9 7.1 6.0 6.2 6.5 6.0 1.4 1 1 0 1 1 1 0 Tetraspanin family TrpP PF17099.5 AIF82206.1 - 0.058 13.2 2.4 0.07 12.9 2.4 1.1 1 0 0 1 1 1 0 Tryptophan transporter TrpP DUF4064 PF13273.6 AIF82206.1 - 5.8 7.2 11.9 27 5.1 10.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) MS_channel PF00924.18 AIF82207.1 - 1e-14 54.6 7.8 3.2e-14 53.0 6.7 2.1 2 0 0 2 2 2 1 Mechanosensitive ion channel Fimbrial_PilY2 PF14481.6 AIF82207.1 - 0.047 13.4 0.7 0.17 11.5 0.0 2.2 2 1 1 3 3 3 0 Type 4 fimbrial biogenesis protein PilY2 Glyco_hydro_43 PF04616.14 AIF82207.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 43 DUF5337 PF17272.2 AIF82207.1 - 0.14 12.0 1.5 0.37 10.6 1.5 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5337) Cation_efflux PF01545.21 AIF82207.1 - 1.1 8.9 13.8 2 8.1 13.8 1.4 1 0 0 1 1 1 0 Cation efflux family DUF2975 PF11188.8 AIF82207.1 - 2.1 8.3 15.1 0.16 11.9 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2975) Polysacc_synt_C PF14667.6 AIF82207.1 - 3.6 7.6 16.3 13 5.8 16.0 1.9 1 1 1 2 2 2 0 Polysaccharide biosynthesis C-terminal domain DUF4179 PF13786.6 AIF82208.1 - 0.072 13.6 0.3 0.081 13.4 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) TMIE PF16038.5 AIF82209.1 - 0.11 12.4 1.5 0.13 12.1 1.5 1.2 1 0 0 1 1 1 0 TMIE protein Phage_cap_E PF03864.15 AIF82210.1 - 0.015 14.5 0.4 0.035 13.3 0.1 1.7 2 0 0 2 2 2 0 Phage major capsid protein E 7tm_2 PF00002.24 AIF82211.1 - 0.051 12.9 0.2 0.087 12.1 0.2 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) Enkurin PF13864.6 AIF82211.1 - 0.068 13.6 2.6 3.2 8.2 0.3 2.3 2 1 0 2 2 2 0 Calmodulin-binding Pox_A_type_inc PF04508.12 AIF82211.1 - 0.19 11.7 0.4 0.38 10.7 0.4 1.5 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Cupredoxin_1 PF13473.6 AIF82212.1 - 0.00089 19.3 0.0 0.0018 18.4 0.0 1.6 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 AIF82212.1 - 0.0045 17.4 0.0 0.01 16.2 0.0 1.6 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cu-oxidase_3 PF07732.15 AIF82212.1 - 0.0055 16.7 0.0 1.7 8.7 0.0 2.5 2 0 0 2 2 2 2 Multicopper oxidase Cupredoxin_1 PF13473.6 AIF82214.1 - 5.3e-10 39.3 0.3 1.5e-09 37.9 0.1 1.9 2 0 0 2 2 2 1 Cupredoxin-like domain Copper-bind PF00127.20 AIF82214.1 - 4.3e-08 33.5 0.1 4.3e-08 33.5 0.1 2.6 1 1 1 2 2 2 1 Copper binding proteins, plastocyanin/azurin family CBM53 PF16760.5 AIF82214.1 - 0.074 13.6 0.1 0.19 12.3 0.1 1.7 1 1 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) DAP PF15228.6 AIF82214.1 - 0.29 12.3 2.2 0.31 12.2 0.5 2.0 2 0 0 2 2 2 0 Death-associated protein TerD PF02342.18 AIF82215.1 - 0.095 12.2 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 TerD domain EcoRII-C PF09019.11 AIF82217.1 - 0.014 15.5 0.1 0.016 15.3 0.1 1.1 1 0 0 1 1 1 0 EcoRII C terminal DUF3490 PF11995.8 AIF82217.1 - 0.031 14.1 0.6 0.031 14.1 0.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) Ferritin_2 PF13668.6 AIF82217.1 - 0.061 13.5 0.1 0.072 13.3 0.1 1.3 1 1 0 1 1 1 0 Ferritin-like domain PAC2 PF09754.9 AIF82218.1 - 1.8e-36 126.2 0.0 2.3e-36 125.8 0.0 1.1 1 0 0 1 1 1 1 PAC2 family Isochorismatase PF00857.20 AIF82219.1 - 9e-37 126.9 0.0 1.1e-36 126.7 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family NYN PF01936.18 AIF82219.1 - 0.1 13.1 0.0 0.38 11.2 0.0 1.9 2 0 0 2 2 2 0 NYN domain Glycos_transf_2 PF00535.26 AIF82220.1 - 9.8e-11 41.8 0.0 1.3e-10 41.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 NTP_transf_3 PF12804.7 AIF82220.1 - 0.00015 22.1 0.0 0.00017 22.0 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain ATP-synt_F PF01990.17 AIF82220.1 - 0.023 15.0 0.0 0.051 13.9 0.0 1.5 1 0 0 1 1 1 0 ATP synthase (F/14-kDa) subunit YwpF PF14183.6 AIF82220.1 - 0.12 12.4 0.0 0.68 9.9 0.0 2.0 2 0 0 2 2 2 0 YwpF-like protein Glycos_transf_1 PF00534.20 AIF82221.1 - 9.7e-24 83.8 0.1 1.7e-23 83.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AIF82221.1 - 1.2e-13 51.7 0.0 3.6e-13 50.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AIF82221.1 - 1.9e-06 28.0 0.0 4.4e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Exostosin PF03016.15 AIF82221.1 - 0.066 12.4 0.0 0.095 11.9 0.0 1.3 1 0 0 1 1 1 0 Exostosin family ALG11_N PF15924.5 AIF82221.1 - 0.12 12.4 0.2 11 6.0 0.3 2.7 2 1 0 2 2 2 0 ALG11 mannosyltransferase N-terminus SBF PF01758.16 AIF82222.1 - 1.1e-13 51.3 13.3 1.1e-13 51.3 13.3 1.6 2 0 0 2 2 2 1 Sodium Bile acid symporter family SBF_like PF13593.6 AIF82222.1 - 5.4e-07 29.2 21.2 8.2e-07 28.6 21.2 1.2 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Peptidase_S9 PF00326.21 AIF82224.1 - 3.3e-07 30.0 0.1 0.0014 18.2 0.0 2.7 2 1 1 3 3 3 2 Prolyl oligopeptidase family DLH PF01738.18 AIF82224.1 - 2.7e-06 27.1 0.0 3.3e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 AIF82224.1 - 4.9e-05 23.1 0.2 0.15 11.6 0.2 3.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AIF82224.1 - 0.00026 20.3 0.0 0.43 9.8 0.0 2.6 3 0 0 3 3 3 2 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 AIF82224.1 - 0.00053 19.7 0.1 0.51 9.9 0.1 2.1 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.11 AIF82224.1 - 0.0018 18.2 0.0 1.4 8.8 0.1 2.2 1 1 1 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Erythro_esteras PF05139.14 AIF82225.1 - 7.8e-105 351.5 5.7 1.1e-104 351.0 5.7 1.1 1 0 0 1 1 1 1 Erythromycin esterase Cofac_haem_bdg PF04187.13 AIF82225.1 - 0.0083 16.1 0.5 4.5 7.2 0.0 2.3 2 0 0 2 2 2 2 Haem-binding uptake, Tiki superfamily, ChaN DUF2795 PF11387.8 AIF82226.1 - 5.2e-13 49.0 0.1 1e-12 48.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2795) DUF3105 PF11303.8 AIF82226.1 - 0.042 14.0 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3105) DUF2795 PF11387.8 AIF82227.1 - 2.3e-23 82.1 0.8 1.5e-11 44.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2795) zf-C2H2_4 PF13894.6 AIF82227.1 - 0.00065 20.3 0.2 0.0015 19.2 0.2 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF82227.1 - 0.004 17.5 0.1 0.0087 16.5 0.1 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type Thr_synth_N PF14821.6 AIF82227.1 - 0.05 13.8 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Threonine synthase N terminus DUF1464 PF07318.12 AIF82227.1 - 0.13 11.4 0.3 0.17 11.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) MTH865 PF07747.11 AIF82227.1 - 0.14 11.9 0.1 4.3 7.2 0.0 2.7 3 0 0 3 3 3 0 MTH865-like family YcaO_C PF18381.1 AIF82227.1 - 0.14 12.0 0.1 4.7 7.1 0.0 2.1 2 0 0 2 2 2 0 YcaO cyclodehydratase C-terminal domain DUF3449 PF11931.8 AIF82227.1 - 0.21 11.4 0.7 0.4 10.5 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) DUF5519 PF17648.1 AIF82228.1 - 2.1e-23 82.4 0.1 2.2e-23 82.3 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5519) HicB PF05534.12 AIF82229.1 - 0.0018 18.1 0.0 0.0032 17.3 0.0 1.4 1 0 0 1 1 1 1 HicB family Arc PF03869.14 AIF82229.1 - 0.019 14.8 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Arc-like DNA binding domain CopG_antitoxin PF12441.8 AIF82229.1 - 0.038 14.5 0.1 0.078 13.5 0.1 1.6 1 0 0 1 1 1 0 CopG antitoxin of type II toxin-antitoxin system RHH_5 PF07878.11 AIF82229.1 - 0.074 12.9 0.1 0.31 10.9 0.0 1.9 2 0 0 2 2 2 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 DUF2615 PF11027.8 AIF82232.1 - 0.024 14.7 1.1 0.038 14.1 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) PepSY PF03413.19 AIF82232.1 - 0.025 15.2 0.1 0.041 14.4 0.1 1.3 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain COX4 PF02936.14 AIF82232.1 - 0.089 12.8 0.2 0.15 12.1 0.2 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV DUF2681 PF10883.8 AIF82232.1 - 0.15 12.5 2.6 0.24 11.9 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Na_H_antiport_1 PF06965.12 AIF82235.1 - 0.0015 17.5 0.2 0.0021 17.0 0.2 1.1 1 0 0 1 1 1 1 Na+/H+ antiporter 1 DUF2569 PF10754.9 AIF82235.1 - 0.019 15.4 0.2 0.029 14.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) DUF4834 PF16118.5 AIF82235.1 - 0.66 11.0 3.3 1.2 10.1 2.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) zf-C2H2_6 PF13912.6 AIF82236.1 - 6.1e-07 29.3 0.2 7.7e-07 29.0 0.2 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AIF82236.1 - 2.2e-05 24.6 0.2 3.3e-05 24.0 0.2 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 AIF82236.1 - 4.9e-05 23.6 0.3 6.7e-05 23.1 0.3 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf_UBZ PF18439.1 AIF82236.1 - 0.00011 21.7 3.5 0.00023 20.7 1.8 2.2 2 1 0 2 2 2 1 Ubiquitin-Binding Zinc Finger zf-C2H2_4 PF13894.6 AIF82236.1 - 0.00019 22.0 0.3 0.00027 21.5 0.3 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.7 AIF82236.1 - 0.0012 19.2 0.1 0.0018 18.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 AIF82236.1 - 0.016 14.8 0.2 0.023 14.3 0.2 1.3 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_2 PF13465.6 AIF82236.1 - 0.023 15.1 2.4 0.026 14.9 0.4 1.9 2 0 0 2 2 2 0 Zinc-finger double domain ABC_tran PF00005.27 AIF82237.1 - 1.6e-29 103.1 0.0 3.6e-29 102.0 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIF82237.1 - 6.8e-13 49.1 0.2 3e-08 33.8 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 AIF82237.1 - 1.1e-10 42.1 0.0 7.4e-10 39.4 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) AAA_15 PF13175.6 AIF82237.1 - 3.6e-05 23.7 0.0 0.075 12.7 0.0 2.6 2 1 1 3 3 3 2 AAA ATPase domain NB-ARC PF00931.22 AIF82237.1 - 0.002 17.4 0.0 0.004 16.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA PF00004.29 AIF82237.1 - 0.0075 16.7 0.1 0.036 14.5 0.1 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 AIF82237.1 - 0.011 15.5 0.1 0.28 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 AIF82237.1 - 0.018 14.5 0.1 4.9 6.5 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 AIF82237.1 - 0.12 12.2 0.1 0.53 10.2 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA_23 PF13476.6 AIF82237.1 - 6.5 7.2 8.5 0.2 12.1 0.7 2.2 1 1 0 2 2 2 0 AAA domain ABC2_membrane PF01061.24 AIF82238.1 - 2.5e-38 131.6 18.3 2.5e-38 131.6 18.3 1.4 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 AIF82238.1 - 1.4e-15 57.3 23.7 1.4e-15 57.3 23.7 1.5 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 AIF82238.1 - 1.8e-14 53.7 16.0 2.3e-14 53.4 16.0 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 AIF82238.1 - 0.0054 16.7 9.5 0.0054 16.7 9.5 2.3 1 1 1 2 2 2 1 ABC-2 family transporter protein PNTB_4TM PF12769.7 AIF82238.1 - 0.52 10.8 12.0 2.9 8.4 3.6 3.9 1 1 1 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch zf-C2H2 PF00096.26 AIF82239.1 - 0.0011 19.3 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF82239.1 - 0.0012 19.4 0.0 0.0017 19.0 0.0 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AIF82239.1 - 0.0063 16.8 0.2 0.0094 16.2 0.1 1.4 1 1 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AIF82239.1 - 0.0074 16.3 0.1 0.0094 15.9 0.1 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_3 PF13878.6 AIF82239.1 - 0.016 15.0 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO zf-C2H2_9 PF16293.5 AIF82239.1 - 0.026 14.4 0.1 0.029 14.2 0.1 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) APP_E2 PF12925.7 AIF82239.1 - 0.051 13.3 0.2 0.057 13.1 0.2 1.0 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein Vps36-NZF-N PF16988.5 AIF82239.1 - 0.068 12.6 0.0 0.075 12.4 0.0 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain HATPase_c PF02518.26 AIF82242.1 - 2.2e-24 86.1 0.8 9.2e-24 84.1 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 AIF82242.1 - 1.9e-21 77.0 3.5 3.9e-21 76.0 3.5 1.5 1 0 0 1 1 1 1 Cache domain HisKA PF00512.25 AIF82242.1 - 5e-13 48.9 0.4 5e-13 48.9 0.4 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 AIF82242.1 - 0.0096 15.8 0.3 0.039 13.8 0.3 2.1 1 1 0 1 1 1 1 GHKL domain Response_reg PF00072.24 AIF82244.1 - 1.6e-19 70.1 0.1 2e-19 69.8 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain COX4_pro_2 PF07835.12 AIF82248.1 - 0.22 11.7 1.7 0.29 11.2 1.7 1.2 1 0 0 1 1 1 0 Bacterial aa3 type cytochrome c oxidase subunit IV HTH_45 PF14947.6 AIF82251.1 - 1.7e-15 56.8 1.0 2.5e-15 56.2 1.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix zf-PARP PF00645.18 AIF82252.1 - 0.00047 21.0 0.9 0.00055 20.7 0.9 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region 7TM_GPCR_Sru PF10322.9 AIF82252.1 - 0.012 15.0 0.1 0.012 15.0 0.1 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sru DUF572 PF04502.13 AIF82252.1 - 0.036 13.7 1.1 0.043 13.5 1.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) C1_1 PF00130.22 AIF82252.1 - 0.055 13.4 1.5 0.18 11.7 1.5 1.7 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) NitrOD2 PF18550.1 AIF82253.1 - 1.5e-30 105.4 0.0 2.5e-30 104.7 0.0 1.3 1 0 0 1 1 1 1 Nitrososphaera output domain 2 Response_reg PF00072.24 AIF82253.1 - 2.9e-16 59.6 0.2 1.6e-15 57.3 0.2 2.0 1 1 0 1 1 1 1 Response regulator receiver domain Cation_efflux PF01545.21 AIF82255.1 - 3.4e-30 105.3 13.7 4.7e-30 104.8 13.7 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 AIF82255.1 - 0.0039 17.3 0.3 0.0065 16.6 0.3 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF2976 PF11190.8 AIF82255.1 - 0.038 13.8 2.2 0.17 11.7 2.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2976) CBM_11 PF03425.13 AIF82257.1 - 0.066 13.1 0.0 0.085 12.7 0.0 1.1 1 0 0 1 1 1 0 Carbohydrate binding domain (family 11) Pro-rich PF15240.6 AIF82258.1 - 4.3e-05 23.9 4.3 5.5e-05 23.5 4.3 1.2 1 0 0 1 1 1 1 Proline-rich Metallophos_C PF14008.6 AIF82259.1 - 0.038 14.8 0.5 0.14 13.1 0.0 2.2 2 1 0 2 2 2 0 Iron/zinc purple acid phosphatase-like protein C Mucin PF01456.17 AIF82259.1 - 0.051 13.6 3.0 0.36 10.8 0.1 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein CHB_HEX_C_1 PF13290.6 AIF82260.1 - 5.1e-15 55.2 5.6 5.1e-15 55.2 5.6 3.9 3 0 0 3 3 3 1 Chitobiase/beta-hexosaminidase C-terminal domain Polysacc_deac_1 PF01522.21 AIF82260.1 - 1.9e-11 44.0 0.0 3.6e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Fn3_assoc PF13287.6 AIF82260.1 - 8.8e-11 41.8 1.4 8.8e-11 41.8 1.4 3.1 3 0 0 3 3 3 1 Fn3 associated HYR PF02494.16 AIF82260.1 - 5.8e-06 26.5 11.8 0.00017 21.9 1.3 3.8 4 0 0 4 4 4 2 HYR domain ASH PF15780.5 AIF82260.1 - 0.0039 17.3 0.2 0.015 15.5 0.2 2.0 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Y_Y_Y PF07495.13 AIF82260.1 - 0.0087 16.0 1.2 1.1 9.3 0.1 3.0 3 0 0 3 3 3 1 Y_Y_Y domain Glyco_hydro_57 PF03065.15 AIF82260.1 - 0.021 14.0 0.0 0.032 13.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 C5-epim_C PF06662.13 AIF82261.1 - 5.8e-19 68.3 4.9 1.3e-18 67.2 4.9 1.5 1 1 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 AIF82261.1 - 0.0031 16.1 0.7 0.029 12.9 0.6 1.9 1 1 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_88 PF07470.13 AIF82261.1 - 0.021 13.9 1.7 0.052 12.6 0.8 1.9 1 1 1 2 2 2 0 Glycosyl Hydrolase Family 88 Tenui_NS3 PF05310.12 AIF82261.1 - 0.057 13.5 0.1 1.1 9.3 0.0 2.3 2 1 0 2 2 2 0 Tenuivirus movement protein RELT PF12606.8 AIF82262.1 - 0.5 9.4 2.8 2.4 7.2 1.6 2.3 2 0 0 2 2 2 0 Tumour necrosis factor receptor superfamily member 19 AmoC PF04896.12 AIF82263.1 - 1e-12 47.8 5.7 1.3e-12 47.6 5.7 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C RTA1 PF04479.13 AIF82263.1 - 0.0079 15.8 0.2 0.013 15.1 0.2 1.3 1 0 0 1 1 1 1 RTA1 like protein Polysacc_deac_1 PF01522.21 AIF82264.1 - 3.3e-07 30.2 0.0 8e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 Polysaccharide deacetylase Big_7 PF17957.1 AIF82264.1 - 4.5e-05 24.1 5.2 4.5e-05 24.1 5.2 3.0 2 1 1 3 3 3 1 Bacterial Ig domain HYR PF02494.16 AIF82264.1 - 0.0004 20.7 0.6 0.0004 20.7 0.6 2.6 3 0 0 3 3 3 1 HYR domain Big_3_3 PF13750.6 AIF82264.1 - 0.054 13.1 2.9 0.29 10.8 0.2 2.9 2 1 1 3 3 3 0 Bacterial Ig-like domain (group 3) MFS_1 PF07690.16 AIF82265.1 - 2.4e-31 109.0 37.4 2.4e-31 109.0 37.4 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 AIF82265.1 - 1.2e-05 24.4 8.8 0.0043 15.9 0.1 3.0 1 1 2 3 3 3 2 MFS_1 like family DUF3899 PF13038.6 AIF82265.1 - 0.2 12.2 4.7 0.22 12.0 0.2 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF3899) PTS_EIIA_2 PF00359.22 AIF82267.1 - 0.071 13.0 0.0 0.076 12.9 0.0 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 DUF4023 PF13215.6 AIF82267.1 - 0.14 12.2 0.4 0.21 11.6 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) RecR PF02132.15 AIF82270.1 - 0.028 14.0 2.0 0.24 11.0 0.4 2.1 2 0 0 2 2 2 0 RecR protein Osmo_CC PF08946.10 AIF82273.1 - 0.16 12.2 0.0 0.18 12.1 0.0 1.1 1 0 0 1 1 1 0 Osmosensory transporter coiled coil HTH_45 PF14947.6 AIF82274.1 - 5.9e-11 42.2 0.2 6.2e-11 42.1 0.2 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix BRCA2 PF00634.18 AIF82275.1 - 0.27 10.9 2.0 1.5 8.5 0.1 2.3 2 0 0 2 2 2 0 BRCA2 repeat MEDS PF14417.6 AIF82276.1 - 0.00023 21.0 0.1 0.0003 20.7 0.1 1.2 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain AAA_22 PF13401.6 AIF82276.1 - 0.0092 16.3 0.0 0.01 16.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain DUF2325 PF10087.9 AIF82276.1 - 0.016 15.3 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) DUF835 PF05763.12 AIF82276.1 - 0.094 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF835) Response_reg PF00072.24 AIF82277.1 - 1.5e-21 76.6 0.0 1.8e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain MEDS PF14417.6 AIF82278.1 - 2e-14 53.7 0.1 2.4e-14 53.5 0.1 1.1 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain ATPase PF06745.13 AIF82278.1 - 6.7e-06 25.6 0.0 9e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 KaiC WD40_3 PF15911.5 AIF82278.1 - 0.063 13.3 0.0 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 WD domain, G-beta repeat zf-C2H2_6 PF13912.6 AIF82280.1 - 3.8e-05 23.6 6.7 0.0027 17.7 0.7 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF82280.1 - 0.0017 18.7 16.4 0.041 14.3 0.6 2.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF82280.1 - 0.0018 18.9 11.3 0.02 15.7 0.1 2.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 AIF82280.1 - 0.035 14.8 8.0 0.15 12.8 4.5 2.0 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats Lar_restr_allev PF14354.6 AIF82280.1 - 0.054 13.9 2.5 0.11 12.9 2.5 1.6 1 1 0 1 1 1 0 Restriction alleviation protein Lar ZZ PF00569.17 AIF82280.1 - 0.066 13.0 4.2 3.3 7.6 0.5 2.4 2 0 0 2 2 2 0 Zinc finger, ZZ type XPA_N PF01286.18 AIF82280.1 - 0.34 11.0 5.8 1.9 8.6 0.5 2.4 2 0 0 2 2 2 0 XPA protein N-terminal UPF0561 PF10573.9 AIF82280.1 - 0.49 10.5 6.7 0.26 11.4 3.6 1.8 1 1 1 2 2 2 0 Uncharacterised protein family UPF0561 DUF629 PF04780.12 AIF82280.1 - 0.61 8.6 12.2 1.6 7.2 12.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF629) Zn-ribbon_8 PF09723.10 AIF82280.1 - 1.1 9.4 6.5 5.2 7.3 4.6 2.3 1 1 1 2 2 2 0 Zinc ribbon domain zf-HYPF PF07503.12 AIF82280.1 - 1.2 8.9 5.5 0.25 11.1 1.4 1.9 2 0 0 2 2 2 0 HypF finger zf-H2C2_2 PF13465.6 AIF82280.1 - 2.3 8.8 16.4 0.74 10.3 3.2 3.1 3 0 0 3 3 3 0 Zinc-finger double domain HATPase_c PF02518.26 AIF82283.1 - 1.4e-23 83.5 0.2 6.7e-23 81.3 0.1 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIF82283.1 - 1.1e-12 47.7 2.1 2.6e-12 46.6 0.6 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 AIF82283.1 - 0.049 13.5 0.4 0.73 9.8 0.3 3.1 3 1 0 3 3 3 0 GHKL domain Cu-oxidase_3 PF07732.15 AIF82285.1 - 8.2e-24 83.9 10.7 4.4e-23 81.5 0.1 3.8 4 1 0 4 4 4 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 AIF82285.1 - 6.6e-17 61.5 11.0 3.9e-09 36.4 1.3 4.0 3 2 0 3 3 3 2 Multicopper oxidase Copper-bind PF00127.20 AIF82285.1 - 2.5e-11 43.9 2.6 2.2e-08 34.4 0.3 3.3 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF82285.1 - 9.4e-11 41.7 0.0 1.2e-07 31.8 0.0 3.5 3 1 0 3 3 3 2 Cupredoxin-like domain Cu-oxidase PF00394.22 AIF82285.1 - 7.3e-05 22.9 0.3 0.044 13.9 0.0 3.5 3 0 0 3 3 3 1 Multicopper oxidase Self-incomp_S1 PF05938.11 AIF82285.1 - 0.13 12.8 0.0 0.86 10.2 0.0 2.3 3 0 0 3 3 3 0 Plant self-incompatibility protein S1 DNA_gyraseA_C PF03989.13 AIF82286.1 - 0.046 13.2 0.1 0.057 12.9 0.1 1.3 1 0 0 1 1 1 0 DNA gyrase C-terminal domain, beta-propeller CopG_antitoxin PF12441.8 AIF82287.1 - 4.1e-05 24.0 0.0 0.00011 22.6 0.0 1.8 1 0 0 1 1 1 1 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIF82287.1 - 0.00019 21.2 0.0 0.00082 19.2 0.0 2.0 2 0 0 2 2 2 1 HicB family RNR_N PF08343.10 AIF82287.1 - 0.002 18.1 0.0 0.0038 17.2 0.0 1.4 1 0 0 1 1 1 1 Ribonucleotide reductase N-terminal RHH_5 PF07878.11 AIF82287.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 Arc PF03869.14 AIF82287.1 - 0.16 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Arc-like DNA binding domain Response_reg PF00072.24 AIF82293.1 - 0.00034 20.7 0.1 0.00049 20.2 0.1 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Mg296 PF09644.10 AIF82293.1 - 0.037 14.2 0.0 0.039 14.1 0.0 1.1 1 0 0 1 1 1 0 Mg296 protein Polysacc_deac_1 PF01522.21 AIF82295.1 - 6.5e-12 45.4 0.0 1.1e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIF82295.1 - 1.4e-07 31.4 0.0 2.2e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) HYR PF02494.16 AIF82295.1 - 0.001 19.3 4.5 0.0012 19.1 1.8 2.4 2 0 0 2 2 2 1 HYR domain Glyco_hydro_57 PF03065.15 AIF82295.1 - 0.042 13.0 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 PepSY PF03413.19 AIF82297.1 - 1.4e-12 48.0 0.7 1.6e-07 31.8 0.0 2.4 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain gp45-slide_C PF09116.10 AIF82297.1 - 0.046 13.8 0.2 0.26 11.4 0.0 2.0 1 1 1 2 2 2 0 gp45 sliding clamp, C terminal Arc_trans_TRASH PF08394.10 AIF82298.1 - 0.0048 17.2 1.1 0.0086 16.4 1.1 1.5 1 0 0 1 1 1 1 Archaeal TRASH domain Cupredoxin_1 PF13473.6 AIF82300.1 - 5.5e-06 26.4 0.0 7.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Cupredoxin-like domain ATP19 PF11022.8 AIF82302.1 - 0.14 12.5 0.1 0.22 11.9 0.1 1.3 1 0 0 1 1 1 0 ATP synthase subunit K NTP_transf_5 PF14907.6 AIF82303.1 - 7.5e-07 29.0 0.0 9.6e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised nucleotidyltransferase DUF4269 PF14091.6 AIF82303.1 - 0.031 14.5 0.0 0.055 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4269) PsiB PF06290.11 AIF82305.1 - 0.039 13.4 0.3 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 Plasmid SOS inhibition protein (PsiB) HARE-HTH PF05066.13 AIF82305.1 - 0.15 12.5 0.0 0.82 10.1 0.0 1.9 2 0 0 2 2 2 0 HB1, ASXL, restriction endonuclease HTH domain MADF_DNA_bdg PF10545.9 AIF82306.1 - 0.11 12.9 0.0 7.7 6.9 0.0 2.1 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like PIN PF01850.21 AIF82307.1 - 3.1e-09 37.4 2.5 3.8e-09 37.1 2.5 1.1 1 0 0 1 1 1 1 PIN domain UPF0253 PF06786.12 AIF82308.1 - 0.088 13.1 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0253) Arc PF03869.14 AIF82308.1 - 0.16 11.8 0.7 0.32 10.9 0.0 1.8 2 1 1 3 3 3 0 Arc-like DNA binding domain Arm-DNA-bind_2 PF12167.8 AIF82308.1 - 0.3 11.0 1.8 2.1 8.3 1.0 2.0 1 1 1 2 2 2 0 Arm DNA-binding domain TrkH PF02386.16 AIF82312.1 - 1.7e-32 112.6 17.1 5.5e-32 110.9 17.1 1.8 1 1 0 1 1 1 1 Cation transport protein CBS PF00571.28 AIF82312.1 - 5.6e-20 71.5 0.5 1.9e-10 41.0 0.0 2.7 2 0 0 2 2 2 2 CBS domain SpvD PF05563.12 AIF82312.1 - 0.024 14.3 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Salmonella plasmid virulence protein SpvD ATAD4 PF15321.6 AIF82312.1 - 1 10.7 3.6 2.9 9.3 3.6 1.7 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 Methyltransf_25 PF13649.6 AIF82313.1 - 4.7e-19 68.9 0.0 7.8e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF82313.1 - 5.2e-19 68.7 0.0 9.1e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF82313.1 - 4.9e-17 62.1 0.0 6.2e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF82313.1 - 1.5e-11 44.9 0.0 2.6e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF82313.1 - 5e-11 42.7 0.0 6.6e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF82313.1 - 6.1e-10 38.8 0.0 8.8e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 AIF82313.1 - 1.2e-07 31.4 0.0 1.9e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 AIF82313.1 - 1.9e-07 30.8 0.0 2.7e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 AIF82313.1 - 6.2e-06 25.7 0.0 8.2e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain PCMT PF01135.19 AIF82313.1 - 4e-05 23.5 0.0 5.8e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 AIF82313.1 - 0.00014 21.9 0.0 0.0002 21.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AIF82313.1 - 0.0013 18.1 0.0 0.0017 17.7 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 AIF82313.1 - 0.0043 16.7 0.0 0.006 16.2 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) PrmA PF06325.13 AIF82313.1 - 0.022 14.1 0.0 0.029 13.8 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 AIF82313.1 - 0.069 12.6 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB FmrO PF07091.11 AIF82313.1 - 0.088 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_18 PF12847.7 AIF82313.1 - 0.18 11.7 0.0 0.29 11.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain HATPase_c PF02518.26 AIF82315.1 - 6.4e-24 84.6 0.1 2.9e-23 82.5 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 AIF82315.1 - 3.1e-20 73.0 0.5 6e-20 72.1 0.5 1.5 1 0 0 1 1 1 1 Cache domain HisKA PF00512.25 AIF82315.1 - 1.4e-09 37.9 0.7 1.4e-09 37.9 0.7 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 AIF82315.1 - 0.00022 21.1 0.1 0.00063 19.6 0.1 1.8 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 AIF82315.1 - 0.0021 17.9 0.3 0.011 15.6 0.1 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2681 PF10883.8 AIF82315.1 - 0.016 15.6 5.0 1.1 9.7 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) sCache_3_2 PF17203.4 AIF82315.1 - 0.021 15.0 0.1 8.1 6.6 0.0 2.9 3 0 0 3 3 3 0 Single cache domain 3 SieB PF14163.6 AIF82315.1 - 0.041 13.4 0.1 0.12 11.8 0.1 1.8 1 0 0 1 1 1 0 Super-infection exclusion protein B HATPase_c_2 PF13581.6 AIF82315.1 - 0.051 13.5 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain HHH_5 PF14520.6 AIF82316.1 - 0.0083 16.7 0.0 0.014 16.0 0.0 1.5 1 1 0 1 1 1 1 Helix-hairpin-helix domain RecX PF02631.16 AIF82316.1 - 0.014 15.8 0.1 0.021 15.3 0.1 1.3 1 0 0 1 1 1 0 RecX family DUF3510 PF12022.8 AIF82316.1 - 0.036 14.4 0.0 0.04 14.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) Phage_min_cap2 PF06152.11 AIF82316.1 - 0.057 12.3 0.1 0.066 12.1 0.1 1.0 1 0 0 1 1 1 0 Phage minor capsid protein 2 Clr5 PF14420.6 AIF82316.1 - 0.084 13.1 0.0 0.13 12.5 0.0 1.5 1 1 0 1 1 1 0 Clr5 domain DUF2127 PF09900.9 AIF82318.1 - 5.3e-05 23.5 14.2 0.001 19.3 9.4 2.2 2 0 0 2 2 2 2 Predicted membrane protein (DUF2127) Ytp1 PF10355.9 AIF82318.1 - 0.0075 15.5 2.4 0.0075 15.5 2.4 1.5 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) PGA2 PF07543.12 AIF82318.1 - 0.21 11.6 0.3 0.32 11.0 0.3 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 zf-RRPl_C4 PF17026.5 AIF82320.1 - 0.01 15.9 0.5 0.01 15.9 0.5 1.1 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type Mn_catalase PF05067.12 AIF82321.1 - 8e-71 238.3 0.0 9.6e-71 238.0 0.0 1.0 1 0 0 1 1 1 1 Manganese containing catalase ABM PF03992.16 AIF82322.1 - 0.021 14.9 0.1 0.081 13.1 0.1 1.9 1 1 1 2 2 2 0 Antibiotic biosynthesis monooxygenase DUF883 PF05957.13 AIF82323.1 - 0.0018 18.8 10.6 0.0044 17.6 10.6 1.6 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF883) Phasin PF05597.11 AIF82323.1 - 0.0039 17.2 5.3 0.0042 17.1 5.3 1.0 1 0 0 1 1 1 1 Poly(hydroxyalcanoate) granule associated protein (phasin) YtxH PF12732.7 AIF82323.1 - 0.01 16.4 12.3 0.028 14.9 12.3 1.7 1 1 0 1 1 1 0 YtxH-like protein Apolipoprotein PF01442.18 AIF82323.1 - 0.011 15.7 4.4 0.011 15.6 4.4 1.0 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Tape_meas_lam_C PF09718.10 AIF82323.1 - 0.022 14.9 4.2 0.14 12.3 1.5 2.1 1 1 1 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) ATP-synt_B PF00430.18 AIF82323.1 - 0.23 11.5 13.8 0.25 11.4 13.8 1.0 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) HSP9_HSP12 PF04119.12 AIF82323.1 - 0.33 11.4 8.9 4.3 7.8 9.1 2.6 1 1 0 1 1 1 0 Heat shock protein 9/12 HrpF PF06266.12 AIF82323.1 - 0.38 11.1 6.6 0.48 10.7 6.4 1.3 1 1 0 1 1 1 0 HrpF protein ISG65-75 PF11727.8 AIF82323.1 - 1.2 8.3 12.1 1.6 7.9 12.1 1.3 1 0 0 1 1 1 0 Invariant surface glycoprotein Alanine_zipper PF11839.8 AIF82323.1 - 1.3 9.4 26.4 2.9 8.3 10.9 2.1 1 1 1 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein RRF PF01765.19 AIF82323.1 - 2.2 8.2 8.9 2.3 8.1 8.9 1.0 1 0 0 1 1 1 0 Ribosome recycling factor Pex26 PF07163.12 AIF82324.1 - 0.025 13.9 0.2 0.026 13.8 0.2 1.0 1 0 0 1 1 1 0 Pex26 protein NitrOD2 PF18550.1 AIF82325.1 - 3.1e-24 85.1 0.0 3.4e-24 85.0 0.0 1.0 1 0 0 1 1 1 1 Nitrososphaera output domain 2 TspO_MBR PF03073.15 AIF82327.1 - 0.00097 19.2 3.2 0.0014 18.6 3.2 1.2 1 0 0 1 1 1 1 TspO/MBR family PrgI PF12666.7 AIF82327.1 - 0.0073 17.0 2.7 0.0079 16.9 2.3 1.3 1 1 0 1 1 1 1 PrgI family protein PhoR PF11808.8 AIF82327.1 - 0.053 13.9 1.0 0.053 13.9 1.0 1.7 1 1 1 2 2 2 0 Phosphate regulon sensor protein PhoR TM2 PF05154.16 AIF82327.1 - 3.9 7.9 11.0 20 5.6 11.0 2.1 1 1 0 1 1 1 0 TM2 domain DUF575 PF04746.12 AIF82329.1 - 0.0026 18.0 0.0 0.0026 18.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF575) KaiB PF07689.12 AIF82330.1 - 0.09 12.5 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 KaiB domain UBZ_FAAP20 PF15750.5 AIF82332.1 - 0.048 13.6 0.1 1.3 9.0 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-binding zinc-finger Cupin_2 PF07883.11 AIF82333.1 - 6.5e-08 32.2 0.3 1.6e-07 30.9 0.1 1.7 2 1 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 AIF82333.1 - 2.2e-07 30.4 0.2 2.1e-05 24.2 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF861) Cupin_1 PF00190.22 AIF82333.1 - 2e-05 24.2 0.2 0.00067 19.3 0.0 2.0 2 0 0 2 2 2 1 Cupin CENP-C_C PF11699.8 AIF82333.1 - 0.038 14.2 0.0 0.096 12.9 0.0 1.6 1 1 1 2 2 2 0 Mif2/CENP-C like CMD PF02627.20 AIF82334.1 - 8.4e-15 54.6 0.0 1.3e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family PIN PF01850.21 AIF82336.1 - 5.6e-08 33.3 0.3 9.2e-08 32.6 0.3 1.3 1 0 0 1 1 1 1 PIN domain DUF3333 PF11812.8 AIF82337.1 - 0.0029 17.8 0.1 0.0032 17.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3333) RHH_1 PF01402.21 AIF82337.1 - 0.022 14.7 0.8 0.12 12.4 0.8 2.3 1 1 0 1 1 1 0 Ribbon-helix-helix protein, copG family NUFIP1 PF10453.9 AIF82337.1 - 0.031 14.1 3.0 0.031 14.1 3.0 2.3 3 0 0 3 3 3 0 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) CENP-X PF09415.10 AIF82337.1 - 0.08 13.3 0.7 0.11 12.8 0.7 1.2 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Response_reg PF00072.24 AIF82338.1 - 0.11 12.7 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 Response regulator receiver domain TackOD1 PF18551.1 AIF82339.1 - 6.4e-32 110.7 8.4 1.1e-31 110.0 8.4 1.3 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 Response_reg PF00072.24 AIF82339.1 - 5.4e-13 49.1 0.1 2.5e-12 47.0 0.0 2.2 2 1 0 2 2 2 1 Response regulator receiver domain DZR PF12773.7 AIF82339.1 - 0.024 14.6 13.1 0.17 11.9 6.1 2.4 1 1 1 2 2 2 0 Double zinc ribbon Cys_rich_KTR PF14205.6 AIF82339.1 - 0.063 13.1 5.8 0.43 10.4 0.1 2.7 2 0 0 2 2 2 0 Cysteine-rich KTR Zn_Tnp_IS1595 PF12760.7 AIF82339.1 - 0.78 9.8 16.0 0.12 12.4 0.6 3.6 3 1 0 3 3 3 0 Transposase zinc-ribbon domain zinc_ribbon_5 PF13719.6 AIF82339.1 - 2.5 7.9 7.3 20 5.1 0.0 3.8 3 0 0 3 3 3 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 AIF82339.1 - 2.9 8.0 17.0 4.4 7.4 1.4 3.2 1 1 0 2 2 2 0 zinc-ribbons zf-TFIIB PF13453.6 AIF82339.1 - 5.1 6.5 7.8 3.5 7.0 0.8 2.8 2 0 0 2 2 2 0 Transcription factor zinc-finger LIM PF00412.22 AIF82339.1 - 5.2 7.4 10.2 10 6.5 2.1 3.5 3 0 0 3 3 3 0 LIM domain zf-C2H2 PF00096.26 AIF82339.1 - 5.8 7.6 13.7 5.3 7.7 0.3 4.4 4 0 0 4 4 4 0 Zinc finger, C2H2 type HypA PF01155.19 AIF82339.1 - 6.9 6.7 15.9 1.2 9.2 0.7 3.7 2 1 2 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Glyco_tranf_2_3 PF13641.6 AIF82340.1 - 4.4e-29 102.0 0.0 7e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 AIF82340.1 - 1.4e-28 99.9 0.0 2.4e-28 99.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 AIF82340.1 - 4.6e-22 78.9 2.7 4.6e-22 78.9 2.7 1.7 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 AIF82340.1 - 1.8e-11 43.8 0.0 2.8e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.15 AIF82340.1 - 2.5e-10 39.6 3.7 0.00049 18.8 4.7 2.9 2 1 0 3 3 3 2 Chitin synthase Glyco_tranf_2_2 PF10111.9 AIF82340.1 - 2.1e-07 30.7 0.0 1.4e-06 28.0 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AIF82340.1 - 0.0016 18.9 0.0 0.0055 17.2 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 2 DUF872 PF05915.12 AIF82340.1 - 5.3 7.2 8.1 0.59 10.3 0.7 2.7 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF872) MazE_antitoxin PF04014.18 AIF82341.1 - 0.00018 21.3 1.9 0.00024 20.9 0.1 2.0 2 0 0 2 2 2 1 Antidote-toxin recognition MazE, bacterial antitoxin PrlF_antitoxin PF15937.5 AIF82341.1 - 0.0027 18.1 0.2 0.0036 17.7 0.2 1.3 1 1 0 1 1 1 1 prlF antitoxin for toxin YhaV_toxin Pyr_redox PF00070.27 AIF82341.1 - 0.018 15.6 0.1 0.028 15.0 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 AIF82341.1 - 0.019 15.2 0.1 0.024 14.9 0.1 1.2 1 0 0 1 1 1 0 TrkA-N domain PIN PF01850.21 AIF82342.1 - 9.9e-11 42.2 0.1 1.1e-10 42.0 0.1 1.1 1 0 0 1 1 1 1 PIN domain PIN_3 PF13470.6 AIF82342.1 - 0.027 15.2 0.1 0.079 13.7 0.1 1.8 1 1 0 1 1 1 0 PIN domain DivIC PF04977.15 AIF82343.1 - 0.074 12.8 2.4 0.11 12.2 2.4 1.3 1 0 0 1 1 1 0 Septum formation initiator RecX PF02631.16 AIF82344.1 - 0.032 14.7 0.0 0.037 14.5 0.0 1.1 1 0 0 1 1 1 0 RecX family Putative_PNPOx PF01243.20 AIF82345.1 - 1.4e-12 47.6 0.0 1.9e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AIF82345.1 - 0.00025 21.1 0.0 0.00032 20.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIF82345.1 - 0.015 14.9 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like Methyltransf_31 PF13847.6 AIF82346.1 - 2.2e-18 66.5 0.0 4.1e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF82346.1 - 5.1e-13 49.5 0.0 9.9e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF82346.1 - 5.1e-11 43.1 0.0 8.9e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF82346.1 - 3.7e-10 40.4 0.0 6.8e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF82346.1 - 9.2e-10 38.6 0.0 1.4e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 AIF82346.1 - 2.8e-08 33.4 0.0 5.7e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 AIF82346.1 - 2.1e-07 30.7 0.0 3.6e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 AIF82346.1 - 1e-05 25.5 0.0 2e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 AIF82346.1 - 1.3e-05 25.1 0.0 1.8e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_2 PF00891.18 AIF82346.1 - 2.1e-05 23.9 0.0 3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Ubie_methyltran PF01209.18 AIF82346.1 - 9.4e-05 21.9 0.0 0.00014 21.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 AIF82346.1 - 0.0011 18.3 0.0 0.0018 17.7 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 AIF82346.1 - 0.0029 17.4 0.0 0.0051 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 AIF82346.1 - 0.0038 16.7 0.0 0.0056 16.1 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB PrmA PF06325.13 AIF82346.1 - 0.0075 15.7 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 AIF82346.1 - 0.055 13.5 0.0 0.085 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Dimerisation PF08100.11 AIF82346.1 - 0.11 12.5 0.0 0.31 11.1 0.0 1.7 2 0 0 2 2 1 0 Dimerisation domain tRNA_U5-meth_tr PF05958.11 AIF82346.1 - 0.23 10.4 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase YdjM PF04307.14 AIF82348.1 - 1.8e-05 24.1 11.2 3.9e-05 23.0 11.2 1.9 1 1 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase Arch_flagellin PF01917.16 AIF82348.1 - 0.0076 16.4 0.1 0.017 15.3 0.1 1.5 1 0 0 1 1 1 1 Archaebacterial flagellin TMEM132D_C PF15706.5 AIF82348.1 - 0.071 12.9 2.0 0.11 12.2 0.5 2.2 2 1 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term PIN PF01850.21 AIF82350.1 - 2.2e-14 54.0 0.5 2.4e-14 53.9 0.5 1.0 1 0 0 1 1 1 1 PIN domain VAPB_antitox PF02697.14 AIF82351.1 - 8.2e-21 74.6 0.8 9.1e-21 74.4 0.8 1.0 1 0 0 1 1 1 1 Putative antitoxin VAPB_antitox PF02697.14 AIF82352.1 - 4.1e-13 49.9 3.3 7.2e-13 49.1 3.3 1.4 1 1 0 1 1 1 1 Putative antitoxin PIN PF01850.21 AIF82353.1 - 6.3e-12 46.1 0.1 7.1e-12 45.9 0.1 1.0 1 0 0 1 1 1 1 PIN domain PIN_3 PF13470.6 AIF82353.1 - 0.04 14.7 0.2 0.049 14.4 0.2 1.1 1 0 0 1 1 1 0 PIN domain DUF4381 PF14316.6 AIF82357.1 - 0.058 13.6 0.1 0.067 13.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Gram_pos_anchor PF00746.21 AIF82357.1 - 0.08 12.9 0.0 0.08 12.9 0.0 2.7 3 0 0 3 3 3 0 LPXTG cell wall anchor motif GAPT PF11770.8 AIF82357.1 - 0.089 12.6 0.0 0.099 12.5 0.0 1.1 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Na_H_Exchanger PF00999.21 AIF82357.1 - 0.14 10.9 1.4 0.16 10.7 1.4 1.0 1 0 0 1 1 1 0 Sodium/hydrogen exchanger family PIN PF01850.21 AIF82359.1 - 1.3e-18 67.7 0.3 1.5e-18 67.5 0.3 1.0 1 0 0 1 1 1 1 PIN domain DUF4411 PF14367.6 AIF82359.1 - 0.00061 19.7 0.0 0.00077 19.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4411) PIN_3 PF13470.6 AIF82359.1 - 0.014 16.1 0.0 0.025 15.3 0.0 1.4 1 1 0 1 1 1 0 PIN domain MazE_antitoxin PF04014.18 AIF82360.1 - 2.9e-10 39.8 1.6 4.9e-10 39.1 1.6 1.4 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin PrlF_antitoxin PF15937.5 AIF82360.1 - 0.035 14.5 0.1 0.071 13.6 0.0 1.4 1 1 0 1 1 1 0 prlF antitoxin for toxin YhaV_toxin Fapy_DNA_glyco PF01149.24 AIF82361.1 - 0.055 14.1 0.1 2.3 8.9 0.0 2.1 2 0 0 2 2 2 0 Formamidopyrimidine-DNA glycosylase N-terminal domain MannoseP_isomer PF01050.18 AIF82362.1 - 2.9e-24 85.7 0.0 3.2e-24 85.5 0.0 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.11 AIF82362.1 - 5.3e-10 38.9 0.0 7.4e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 AIF82362.1 - 0.00083 19.3 0.0 0.0014 18.6 0.0 1.4 1 1 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.12 AIF82362.1 - 0.001 18.7 0.0 0.002 17.8 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF861) Pirin_C_2 PF17954.1 AIF82362.1 - 0.0012 19.0 0.0 0.0016 18.6 0.0 1.2 1 0 0 1 1 1 1 Quercetinase C-terminal cupin domain Lyx_isomer PF07385.12 AIF82362.1 - 0.015 14.5 0.0 0.028 13.7 0.0 1.4 1 1 0 1 1 1 0 D-lyxose isomerase DUF4384 PF14326.6 AIF82362.1 - 0.017 15.2 0.0 0.024 14.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4384) Cupin_1 PF00190.22 AIF82362.1 - 0.041 13.5 0.0 0.053 13.1 0.0 1.2 1 0 0 1 1 1 0 Cupin FdtA PF05523.11 AIF82362.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.3 1 1 0 1 1 1 0 WxcM-like, C-terminal CENP-C_C PF11699.8 AIF82362.1 - 0.12 12.6 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Mif2/CENP-C like Cupin_6 PF12852.7 AIF82362.1 - 0.2 11.4 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 Cupin UPF0139 PF03669.13 AIF82364.1 - 0.054 13.4 1.1 0.85 9.5 0.0 3.2 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0139) N6_Mtase PF02384.16 AIF82367.1 - 8.8e-32 110.6 0.0 3e-31 108.9 0.0 1.9 2 0 0 2 2 2 1 N-6 DNA Methylase HSDR_N_2 PF13588.6 AIF82367.1 - 9.8e-27 93.1 0.0 2.6e-26 91.8 0.0 1.7 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) UPF0020 PF01170.18 AIF82367.1 - 2.5e-08 33.9 0.0 6.9e-08 32.4 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.14 AIF82367.1 - 0.00033 20.3 0.0 0.47 10.0 0.0 3.3 3 0 0 3 3 3 1 Methyltransferase small domain Methyltransf_31 PF13847.6 AIF82367.1 - 0.013 15.3 0.0 0.16 11.8 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain HSDR_N PF04313.14 AIF82367.1 - 0.044 13.7 0.0 0.46 10.4 0.0 2.4 1 1 1 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Methylase_S PF01420.19 AIF82368.1 - 2.4e-10 40.9 0.3 0.00012 22.3 0.1 2.3 2 0 0 2 2 2 2 Type I restriction modification DNA specificity domain ParE-like_toxin PF15781.5 AIF82369.1 - 1.1e-11 44.5 0.8 1.4e-11 44.2 0.3 1.4 2 0 0 2 2 2 1 ParE-like toxin of type II bacterial toxin-antitoxin system ParE_toxin PF05016.15 AIF82369.1 - 1.4e-07 32.0 0.5 2.8e-07 31.1 0.2 1.6 1 1 1 2 2 2 1 ParE toxin of type II toxin-antitoxin system, parDE DUF5358 PF17311.2 AIF82369.1 - 0.0068 16.4 1.1 0.0078 16.2 1.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5358) Gp49 PF05973.14 AIF82369.1 - 0.022 14.9 0.1 0.043 14.0 0.0 1.5 1 1 0 1 1 1 0 Phage derived protein Gp49-like (DUF891) YoeB_toxin PF06769.14 AIF82369.1 - 0.032 14.3 0.0 0.059 13.4 0.0 1.4 1 1 0 1 1 1 0 YoeB-like toxin of bacterial type II toxin-antitoxin system BCL_N PF04714.13 AIF82369.1 - 0.046 13.8 0.5 0.62 10.2 0.0 2.2 2 0 0 2 2 2 0 BCL7, N-terminal conserver region Memo PF01875.17 AIF82369.1 - 0.081 12.1 0.0 0.098 11.8 0.0 1.0 1 0 0 1 1 1 0 Memo-like protein EF_assoc_1 PF08355.12 AIF82370.1 - 0.19 11.3 1.4 2.2 8.0 0.0 2.5 2 1 1 3 3 3 0 EF hand associated DDE_Tnp_1 PF01609.21 AIF82371.1 - 2.9e-21 76.1 1.1 1e-20 74.3 1.1 1.8 1 1 0 1 1 1 1 Transposase DDE domain PLDc_2 PF13091.6 AIF82374.1 - 4.8e-11 42.7 1.4 8.5e-11 41.9 1.4 1.3 1 0 0 1 1 1 1 PLD-like domain RE_NgoFVII PF09565.10 AIF82374.1 - 0.0081 15.5 0.4 0.015 14.7 0.4 1.4 1 0 0 1 1 1 1 NgoFVII restriction endonuclease PP_kinase_C PF13090.6 AIF82374.1 - 0.0097 15.4 1.5 0.014 14.9 0.4 1.8 2 0 0 2 2 2 1 Polyphosphate kinase C-terminal domain 2 AbiEii PF08843.11 AIF82376.1 - 4e-31 108.8 0.0 5.5e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase AbiEii toxin, Type IV TA system AbiEi_1 PF09407.10 AIF82377.1 - 2.3e-09 37.7 0.0 4.1e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 AbiEi antitoxin C-terminal domain AbiEi_4 PF13338.6 AIF82377.1 - 5.2e-05 23.3 0.0 0.0001 22.3 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulator, AbiEi antitoxin AAA_30 PF13604.6 AIF82378.1 - 1.8e-21 76.7 0.0 4.3e-21 75.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AIF82378.1 - 2.7e-20 73.2 0.0 6.1e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 AIF82378.1 - 2.3e-13 49.8 0.0 4.9e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 AIF82378.1 - 1.9e-11 44.2 0.1 9.9e-05 22.2 0.0 3.8 4 0 0 4 4 4 3 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 AIF82378.1 - 9.1e-11 42.0 0.2 2.5e-05 24.2 0.1 2.4 1 1 1 2 2 2 2 AAA domain UvrD-helicase PF00580.21 AIF82378.1 - 2.6e-06 27.2 0.9 0.035 13.6 0.1 2.8 1 1 1 2 2 2 2 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 AIF82378.1 - 0.0019 18.5 0.3 0.13 12.5 0.4 3.2 2 1 0 2 2 2 1 AAA domain CLP1_P PF16575.5 AIF82378.1 - 0.005 16.7 0.0 1.7 8.4 0.0 2.4 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop HHH_4 PF14490.6 AIF82378.1 - 0.0055 16.6 0.1 0.12 12.3 0.1 2.8 1 1 0 1 1 1 1 Helix-hairpin-helix containing domain DUF2075 PF09848.9 AIF82378.1 - 0.0063 15.8 0.2 0.46 9.7 0.1 2.6 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 AIF82378.1 - 0.0095 15.7 0.0 0.034 13.9 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_RecD PF05127.14 AIF82378.1 - 0.011 15.7 0.1 0.13 12.2 0.1 2.4 1 1 0 1 1 1 0 Helicase CbiA PF01656.23 AIF82378.1 - 0.011 15.8 0.0 0.041 13.9 0.0 2.0 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain T2SSE PF00437.20 AIF82378.1 - 0.019 14.0 0.0 0.035 13.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 AIF82378.1 - 0.02 15.3 0.0 0.07 13.5 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 AIF82378.1 - 0.027 13.9 0.1 0.1 12.0 0.1 1.9 1 1 0 1 1 1 0 PhoH-like protein TrwB_AAD_bind PF10412.9 AIF82378.1 - 0.052 12.4 0.0 0.12 11.3 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_25 PF13481.6 AIF82378.1 - 0.081 12.5 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AIF82378.1 - 0.18 12.0 0.0 0.42 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 AIF82378.1 - 0.64 10.1 2.9 3.4 7.7 0.1 3.3 4 0 0 4 4 4 0 Helicase HerA, central domain Phageshock_PspD PF09584.10 AIF82379.1 - 0.075 13.1 0.2 0.17 12.0 0.2 1.5 1 0 0 1 1 1 0 Phage shock protein PspD (Phageshock_PspD) AcrZ PF10766.9 AIF82379.1 - 2.4 7.8 4.8 5.1 6.7 4.8 1.5 1 0 0 1 1 1 0 Multidrug efflux pump-associated protein AcrZ AAA_16 PF13191.6 AIF82381.1 - 0.0013 19.1 0.0 0.0022 18.4 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AIF82381.1 - 0.0017 18.6 0.2 0.023 15.0 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 AIF82381.1 - 0.013 15.2 0.2 0.033 13.9 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 AIF82381.1 - 0.021 14.8 0.3 0.04 13.8 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 AIF82381.1 - 0.025 14.5 0.2 0.087 12.7 0.1 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_30 PF13604.6 AIF82381.1 - 0.025 14.3 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 AIF82381.1 - 0.032 14.7 1.2 0.054 14.0 0.2 1.8 2 0 0 2 2 2 0 AAA domain ParBc PF02195.18 AIF82386.1 - 4.8e-23 81.3 0.1 1.6e-22 79.6 0.0 1.9 2 0 0 2 2 2 1 ParB-like nuclease domain KorB PF08535.10 AIF82386.1 - 0.00044 20.2 0.1 0.0012 18.8 0.1 1.9 1 0 0 1 1 1 1 KorB domain HTH_ParB PF17762.1 AIF82386.1 - 0.00052 19.8 0.2 0.0017 18.1 0.2 2.0 1 0 0 1 1 1 1 HTH domain found in ParB protein zf-C2H2_2 PF12756.7 AIF82387.1 - 0.013 15.9 0.1 0.014 15.8 0.1 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Glycos_transf_2 PF00535.26 AIF82388.1 - 2.1e-33 115.5 0.1 3.8e-33 114.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIF82388.1 - 5.1e-24 85.4 0.1 6.1e-23 81.9 0.1 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 AIF82388.1 - 4.3e-21 75.1 1.5 9.2e-16 57.5 0.1 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 AIF82388.1 - 8e-14 52.0 5.5 8e-14 52.0 5.5 3.4 2 2 1 3 3 3 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 AIF82388.1 - 2.6e-09 36.8 0.4 2e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 21 NTP_transferase PF00483.23 AIF82388.1 - 0.00078 19.1 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Glyco_tranf_2_4 PF13704.6 AIF82388.1 - 0.006 17.1 0.0 0.023 15.2 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 Polysacc_deac_1 PF01522.21 AIF82389.1 - 2.7e-12 46.7 0.0 4.7e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase UDPG_MGDP_dh PF00984.19 AIF82390.1 - 4.7e-20 71.6 0.0 8.5e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 AIF82390.1 - 3.4e-08 33.3 0.0 0.0041 16.7 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 AIF82390.1 - 0.00013 22.1 0.0 0.00025 21.3 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 AIF82390.1 - 0.00034 20.5 0.1 0.0008 19.3 0.1 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIF82390.1 - 0.00037 19.9 0.0 0.00059 19.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPMT PF05724.11 AIF82390.1 - 0.0057 16.3 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_23 PF13489.6 AIF82390.1 - 0.073 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Antimicrobial20 PF08256.11 AIF82390.1 - 3.4 8.4 4.9 76 4.3 1.2 3.2 3 0 0 3 3 3 0 Aurein-like antibiotic peptide CHB_HEX_C_1 PF13290.6 AIF82392.1 - 1.6e-41 140.2 27.6 7e-21 74.0 9.4 2.8 2 0 0 2 2 2 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 AIF82392.1 - 2.1e-28 98.3 21.5 3.6e-15 55.9 7.5 2.7 2 0 0 2 2 2 2 Fn3 associated Polysacc_deac_1 PF01522.21 AIF82392.1 - 3.3e-12 46.4 0.0 8.8e-12 45.0 0.0 1.8 1 0 0 1 1 1 1 Polysaccharide deacetylase CHB_HEX_C PF03174.13 AIF82392.1 - 0.00089 19.2 0.7 0.72 9.9 0.1 2.6 2 0 0 2 2 2 2 Chitobiase/beta-hexosaminidase C-terminal domain TrkA_C PF02080.21 AIF82392.1 - 0.078 12.8 0.0 48 3.9 0.0 3.7 4 0 0 4 4 4 0 TrkA-C domain SERTA PF06031.13 AIF82394.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 SERTA motif Copper-bind PF00127.20 AIF82395.1 - 4.2e-05 23.9 3.8 0.0045 17.4 0.1 2.7 3 0 0 3 3 3 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF82395.1 - 0.0034 17.5 0.3 0.08 13.1 0.0 2.7 1 1 0 2 2 2 1 Cupredoxin-like domain zf-C2H2_assoc PF16606.5 AIF82395.1 - 0.43 10.8 6.3 0.97 9.7 6.3 1.6 1 0 0 1 1 1 0 Unstructured conserved, between two C2H2-type zinc-fingers GET2 PF08690.10 AIF82395.1 - 1 9.0 3.6 1.5 8.4 3.6 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 LIM PF00412.22 AIF82396.1 - 0.00059 20.0 1.6 0.0014 18.8 1.6 1.7 1 1 0 1 1 1 1 LIM domain DUF35_N PF12172.8 AIF82396.1 - 0.0012 18.7 0.8 0.35 10.8 0.1 2.5 2 0 0 2 2 2 2 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.7 AIF82396.1 - 0.022 14.8 2.3 0.43 10.6 2.3 2.2 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 AIF82396.1 - 0.096 12.6 4.4 4.2 7.4 0.8 2.5 2 0 0 2 2 2 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.13 AIF82396.1 - 0.2 11.3 5.8 1.2 8.9 0.2 3.0 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-dskA_traR PF01258.17 AIF82396.1 - 0.23 11.4 3.3 16 5.5 0.0 3.0 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger zf-ribbon_3 PF13248.6 AIF82396.1 - 0.76 9.3 0.2 0.76 9.3 0.2 3.0 3 0 0 3 3 3 0 zinc-ribbon domain C1_1 PF00130.22 AIF82396.1 - 4.5 7.2 10.4 12 5.9 0.6 2.9 1 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 AIF82396.1 - 5.6 6.9 9.8 34 4.4 3.7 3.3 2 1 1 3 3 3 0 PHD-finger zf-PARP PF00645.18 AIF82396.1 - 5.7 7.9 7.7 0.53 11.2 1.4 2.3 1 1 0 2 2 2 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Cu-oxidase_3 PF07732.15 AIF82397.1 - 2.3e-23 82.5 1.1 2.9e-20 72.5 0.1 3.3 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 AIF82397.1 - 1.1e-16 60.9 7.9 4.6e-07 29.7 0.0 4.7 5 1 1 6 6 6 3 Multicopper oxidase Cupredoxin_1 PF13473.6 AIF82397.1 - 2.7e-08 33.8 0.0 7.7e-06 26.0 0.0 3.7 3 0 0 3 3 3 1 Cupredoxin-like domain Copper-bind PF00127.20 AIF82397.1 - 5.6e-07 29.9 6.5 2.4e-06 27.9 0.0 4.0 2 2 1 3 3 3 1 Copper binding proteins, plastocyanin/azurin family GCR1_C PF12550.8 AIF82398.1 - 0.083 13.2 0.2 0.19 12.1 0.1 1.7 1 1 0 1 1 1 0 Transcriptional activator of glycolytic enzymes DZR PF12773.7 AIF82400.1 - 0.00017 21.5 0.1 0.0002 21.3 0.1 1.2 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 AIF82400.1 - 0.00053 19.6 2.6 0.00078 19.1 2.6 1.3 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 AIF82400.1 - 0.0045 17.7 0.1 0.0058 17.4 0.1 1.2 1 0 0 1 1 1 1 zinc-ribbon family zf-ribbon_3 PF13248.6 AIF82400.1 - 0.11 12.0 3.7 0.26 10.8 3.7 1.7 1 1 0 1 1 1 0 zinc-ribbon domain SpvD PF05563.12 AIF82403.1 - 0.067 12.8 0.1 0.074 12.7 0.1 1.1 1 0 0 1 1 1 0 Salmonella plasmid virulence protein SpvD HAMP PF00672.25 AIF82405.1 - 0.13 12.6 0.0 0.2 12.1 0.0 1.2 1 0 0 1 1 1 0 HAMP domain DUF202 PF02656.15 AIF82407.1 - 3.4e-19 69.0 0.3 3.4e-19 69.0 0.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF4199 PF13858.6 AIF82407.1 - 0.019 15.4 1.0 0.019 15.4 1.0 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) DUF2207 PF09972.9 AIF82407.1 - 0.45 9.2 1.9 0.84 8.3 1.9 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DHHC PF01529.20 AIF82407.1 - 0.54 10.4 1.6 0.76 9.9 0.2 1.8 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF3185 PF11381.8 AIF82407.1 - 4.2 7.5 9.1 15 5.7 5.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3185) RHH_1 PF01402.21 AIF82408.1 - 0.00013 21.8 0.3 0.00026 20.8 0.1 1.7 2 0 0 2 2 2 1 Ribbon-helix-helix protein, copG family RHH_7 PF16777.5 AIF82408.1 - 0.016 15.6 0.0 0.04 14.3 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator, RHH-like, CopG RHH_4 PF13467.6 AIF82408.1 - 0.045 13.6 0.1 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 Ribbon-helix-helix domain CopG_antitoxin PF12441.8 AIF82408.1 - 0.099 13.2 0.0 0.34 11.5 0.0 1.9 2 0 0 2 2 2 0 CopG antitoxin of type II toxin-antitoxin system NitrOD2 PF18550.1 AIF82409.1 - 5.4e-36 122.9 0.1 6.3e-36 122.7 0.1 1.0 1 0 0 1 1 1 1 Nitrososphaera output domain 2 DUF150 PF02576.17 AIF82410.1 - 0.16 12.4 0.0 0.17 12.3 0.0 1.1 1 0 0 1 1 1 0 RimP N-terminal domain GPDPase_memb PF10110.9 AIF82412.1 - 0.058 12.2 0.1 0.066 12.0 0.1 1.2 1 0 0 1 1 1 0 Membrane domain of glycerophosphoryl diester phosphodiesterase Peptidase_M50 PF02163.22 AIF82413.1 - 3.5e-17 62.5 7.0 3.3e-08 33.1 0.1 3.1 2 1 1 3 3 3 2 Peptidase family M50 CBS PF00571.28 AIF82413.1 - 7.5e-17 61.5 0.5 5.9e-07 29.8 0.2 2.4 2 0 0 2 2 2 2 CBS domain Peptidase_M50B PF13398.6 AIF82413.1 - 0.00084 19.0 0.2 0.00084 19.0 0.2 2.5 2 1 0 3 3 3 1 Peptidase M50B-like DUF3267 PF11667.8 AIF82413.1 - 0.046 14.0 0.9 0.046 14.0 0.9 2.3 2 0 0 2 2 2 0 Putative zincin peptidase TctB PF07331.11 AIF82413.1 - 3.8 7.8 16.9 17 5.7 6.4 2.3 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family fn2 PF00040.19 AIF82414.1 - 2.5 8.4 8.3 0.9 9.9 1.6 2.8 2 0 0 2 2 2 0 Fibronectin type II domain PPC PF04151.15 AIF82416.1 - 0.0078 17.3 0.8 0.038 15.1 0.3 2.5 2 0 0 2 2 2 1 Bacterial pre-peptidase C-terminal domain DUF4975 PF16346.5 AIF82416.1 - 0.036 14.2 0.1 0.068 13.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4975) HTH_20 PF12840.7 AIF82417.1 - 3.3e-10 39.9 0.5 6.4e-10 39.0 0.5 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 AIF82417.1 - 2.4e-07 30.5 0.3 4.8e-07 29.5 0.3 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 AIF82417.1 - 4.1e-05 23.0 0.0 8.2e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 AIF82417.1 - 0.0005 19.9 0.1 0.001 18.9 0.1 1.5 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 AIF82417.1 - 0.0018 18.2 0.1 0.0036 17.2 0.1 1.6 1 1 0 1 1 1 1 Crp-like helix-turn-helix domain DprA_WH PF17782.1 AIF82417.1 - 0.0093 16.1 0.1 0.021 14.9 0.1 1.6 1 0 0 1 1 1 1 DprA winged helix domain TrmB PF01978.19 AIF82417.1 - 0.018 14.9 0.0 0.075 12.9 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Sigma70_r4 PF04545.16 AIF82417.1 - 0.1 12.1 0.0 1 8.9 0.0 2.5 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_11 PF08279.12 AIF82417.1 - 0.1 12.5 0.3 0.31 11.0 0.2 1.8 2 0 0 2 2 2 0 HTH domain RE_HaeII PF09554.10 AIF82418.1 - 0.019 14.3 0.0 0.019 14.2 0.0 1.0 1 0 0 1 1 1 0 HaeII restriction endonuclease HATPase_c PF02518.26 AIF82420.1 - 4.9e-23 81.8 1.2 8.5e-23 81.0 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIF82420.1 - 1e-11 44.7 0.5 7.3e-11 41.9 0.0 2.6 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 AIF82420.1 - 0.00017 21.5 0.1 0.00082 19.2 0.1 2.2 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 AIF82420.1 - 0.00027 20.9 0.0 0.0026 17.7 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 AIF82420.1 - 0.025 14.4 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SIMPL PF04402.14 AIF82420.1 - 0.91 9.9 3.2 0.69 10.3 0.9 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF541) DUF5052 PF16475.5 AIF82421.1 - 0.0074 15.9 0.0 0.0084 15.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5052) DUF1064 PF06356.11 AIF82421.1 - 0.054 13.8 0.3 0.072 13.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1064) rve PF00665.26 AIF82423.1 - 4.4e-18 65.6 0.0 1.7e-17 63.7 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain HTH_32 PF13565.6 AIF82423.1 - 1e-13 51.7 1.4 2.1e-13 50.7 0.2 2.2 3 0 0 3 3 2 1 Homeodomain-like domain HTH_28 PF13518.6 AIF82423.1 - 6e-13 48.7 0.0 2.8e-12 46.6 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 AIF82423.1 - 1.3e-10 41.2 0.0 1.3e-09 38.0 0.0 2.3 2 0 0 2 2 2 1 Winged helix-turn helix rve_3 PF13683.6 AIF82423.1 - 1.7e-09 37.3 0.0 1e-08 34.8 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain LZ_Tnp_IS481 PF13011.6 AIF82423.1 - 2.3e-09 37.7 0.0 2.3e-08 34.5 0.0 2.4 2 0 0 2 2 2 1 leucine-zipper of insertion element IS481 HTH_23 PF13384.6 AIF82423.1 - 9.2e-09 34.9 0.9 3.9e-08 32.9 0.0 2.5 3 0 0 3 3 3 1 Homeodomain-like domain HTH_Tnp_1 PF01527.20 AIF82423.1 - 8e-06 26.1 0.0 2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Transposase HTH_Tnp_1_2 PF13022.6 AIF82423.1 - 0.0002 21.5 0.1 0.00052 20.1 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase HTH_Tnp_IS630 PF01710.16 AIF82423.1 - 0.00052 20.0 0.9 0.11 12.5 0.0 2.5 2 0 0 2 2 2 1 Transposase HTH_7 PF02796.15 AIF82423.1 - 0.0014 18.6 0.1 0.0045 17.0 0.0 2.0 2 0 0 2 2 1 1 Helix-turn-helix domain of resolvase HTH_17 PF12728.7 AIF82423.1 - 0.0024 18.0 2.1 0.021 15.0 0.0 3.2 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_21 PF13276.6 AIF82423.1 - 0.0054 16.8 1.5 0.0054 16.8 1.5 2.1 2 0 0 2 2 2 1 HTH-like domain Terminase_5 PF06056.12 AIF82423.1 - 0.0075 16.1 0.2 0.077 12.9 0.0 2.4 2 0 0 2 2 2 1 Putative ATPase subunit of terminase (gpP-like) DUF1153 PF06627.11 AIF82423.1 - 0.016 15.3 0.2 0.051 13.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1153) DDE_Tnp_IS240 PF13610.6 AIF82423.1 - 0.023 14.9 1.0 0.043 14.1 0.0 1.9 2 1 0 2 2 2 0 DDE domain HTH_36 PF13730.6 AIF82423.1 - 0.068 13.1 0.1 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Cupin_3 PF05899.12 AIF82432.1 - 6e-07 29.1 0.2 1.8e-06 27.5 0.2 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF861) Cupin_2 PF07883.11 AIF82432.1 - 4.2e-06 26.4 0.0 7.8e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 AIF82432.1 - 0.0066 16.1 0.0 0.0095 15.5 0.0 1.2 1 0 0 1 1 1 1 Cupin Ribosomal_L31 PF01197.18 AIF82432.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L31 Lon_C PF05362.13 AIF82433.1 - 3.5e-10 39.8 0.1 5.4e-10 39.2 0.1 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain ChlI PF13541.6 AIF82433.1 - 0.013 15.4 0.1 0.024 14.5 0.1 1.5 1 0 0 1 1 1 0 Subunit ChlI of Mg-chelatase AAA PF00004.29 AIF82434.1 - 2.7e-100 332.0 0.1 2.1e-49 167.3 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AIF82434.1 - 1.6e-29 101.4 0.4 5.9e-14 51.6 0.2 2.7 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 AIF82434.1 - 6.2e-23 80.8 0.4 1.9e-22 79.2 0.4 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 AIF82434.1 - 5.7e-17 62.4 0.0 3.4e-08 33.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AIF82434.1 - 2.4e-15 56.6 0.0 1.8e-08 34.3 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AIF82434.1 - 3.4e-13 50.3 0.1 3.7e-05 24.2 0.0 3.9 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 AIF82434.1 - 4.1e-11 43.3 0.6 0.0031 17.8 0.1 3.8 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.14 AIF82434.1 - 7.4e-11 42.2 0.4 0.0004 20.4 0.1 3.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 AIF82434.1 - 2.2e-10 40.3 0.1 0.0014 17.9 0.0 3.3 3 0 0 3 3 3 2 TIP49 P-loop domain CDC48_2 PF02933.17 AIF82434.1 - 1.1e-09 37.9 0.0 3.8e-09 36.2 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.6 AIF82434.1 - 4e-09 36.8 0.0 0.00026 21.2 0.0 2.8 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 AIF82434.1 - 1.2e-07 31.7 0.0 0.015 15.1 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 AIF82434.1 - 2.2e-07 30.4 0.8 0.0078 15.6 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 AIF82434.1 - 2.6e-07 30.8 0.0 0.0016 18.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 AIF82434.1 - 3.6e-07 30.8 0.0 0.022 15.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 AIF82434.1 - 9.3e-07 29.2 0.0 0.067 13.6 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_25 PF13481.6 AIF82434.1 - 1.6e-06 27.8 3.7 0.079 12.5 0.3 3.8 3 1 0 3 3 3 1 AAA domain AAA_7 PF12775.7 AIF82434.1 - 2.2e-06 27.3 0.1 0.056 12.9 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 AIF82434.1 - 3.1e-06 27.0 0.0 0.037 13.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 AIF82434.1 - 5.6e-06 26.2 0.0 0.19 11.4 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_3 PF07726.11 AIF82434.1 - 6e-06 26.2 0.0 0.12 12.2 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 AIF82434.1 - 7.4e-06 26.3 0.0 0.073 13.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 AIF82434.1 - 1.8e-05 24.7 0.0 0.29 11.1 0.0 2.6 2 1 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 AIF82434.1 - 2.2e-05 23.8 0.1 0.15 11.3 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin NACHT PF05729.12 AIF82434.1 - 2.3e-05 24.4 0.1 0.53 10.2 0.0 3.4 3 0 0 3 3 3 2 NACHT domain ATPase PF06745.13 AIF82434.1 - 3.1e-05 23.4 0.2 0.34 10.2 0.0 3.2 3 0 0 3 3 3 2 KaiC AAA_30 PF13604.6 AIF82434.1 - 5e-05 23.1 0.4 0.34 10.6 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 AIF82434.1 - 5.2e-05 23.2 0.0 0.13 12.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 AIF82434.1 - 5.4e-05 23.1 0.0 0.047 13.5 0.0 3.2 2 1 1 3 3 3 1 Bacterial dnaA protein Parvo_NS1 PF01057.17 AIF82434.1 - 0.00013 21.1 0.1 0.15 11.2 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 PhoH PF02562.16 AIF82434.1 - 0.00015 21.3 0.3 0.37 10.2 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein DUF2075 PF09848.9 AIF82434.1 - 0.00024 20.5 0.3 0.096 11.9 0.0 3.0 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 AIF82434.1 - 0.00042 20.3 0.0 0.37 10.7 0.0 2.9 2 1 1 3 3 2 1 ATPase domain predominantly from Archaea AAA_17 PF13207.6 AIF82434.1 - 0.00043 20.7 0.0 1.3 9.5 0.0 3.2 3 0 0 3 3 2 1 AAA domain DUF815 PF05673.13 AIF82434.1 - 0.00047 19.4 0.0 0.7 9.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) CPT PF07931.12 AIF82434.1 - 0.00087 19.2 0.2 3.5 7.4 0.0 3.3 3 1 0 3 3 3 0 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.6 AIF82434.1 - 0.00092 19.6 1.2 1.9 8.8 0.0 2.8 2 1 0 2 2 2 2 AAA domain ABC_tran PF00005.27 AIF82434.1 - 0.0011 19.4 0.0 1.6 9.2 0.0 2.5 2 0 0 2 2 2 1 ABC transporter NB-ARC PF00931.22 AIF82434.1 - 0.0012 18.1 0.0 0.43 9.7 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain AFG1_ATPase PF03969.16 AIF82434.1 - 0.0026 16.7 0.0 0.65 8.8 0.0 2.2 2 0 0 2 2 2 1 AFG1-like ATPase ResIII PF04851.15 AIF82434.1 - 0.0027 17.7 0.0 3.5 7.6 0.0 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 AIF82434.1 - 0.0055 16.6 5.1 2.1 8.3 0.0 4.1 4 1 1 5 5 3 1 NTPase Cytidylate_kin PF02224.18 AIF82434.1 - 0.0083 15.9 0.4 2.8 7.6 0.0 2.7 3 0 0 3 3 2 1 Cytidylate kinase TniB PF05621.11 AIF82434.1 - 0.0086 15.5 0.0 2.4 7.5 0.0 2.9 3 0 0 3 3 3 1 Bacterial TniB protein Sigma54_activ_2 PF14532.6 AIF82434.1 - 0.0091 16.1 0.0 4.6 7.4 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain T2SSE PF00437.20 AIF82434.1 - 0.01 14.9 0.0 4.2 6.3 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Viral_helicase1 PF01443.18 AIF82434.1 - 0.013 15.3 0.0 2.6 7.7 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase MCM PF00493.23 AIF82434.1 - 0.015 14.4 0.0 2.5 7.2 0.0 2.7 3 0 0 3 3 2 0 MCM P-loop domain Vps4_C PF09336.10 AIF82434.1 - 0.016 15.2 0.1 1.4 9.0 0.0 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain Zot PF05707.12 AIF82434.1 - 0.021 14.5 0.0 0.48 10.1 0.0 2.7 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) Hydin_ADK PF17213.3 AIF82434.1 - 0.032 14.5 3.0 7.1 6.8 0.0 3.0 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain Guanylate_kin PF00625.21 AIF82434.1 - 0.036 13.8 0.1 9 5.9 0.0 3.4 2 2 0 3 3 3 0 Guanylate kinase AAA_29 PF13555.6 AIF82434.1 - 0.037 13.8 0.1 11 5.9 0.0 2.8 3 0 0 3 3 2 0 P-loop containing region of AAA domain Cytidylate_kin2 PF13189.6 AIF82434.1 - 0.047 13.8 0.0 3.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase-like family UFD1 PF03152.14 AIF82434.1 - 0.052 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 Torsin PF06309.11 AIF82434.1 - 0.075 13.1 0.0 3.8 7.6 0.0 2.5 2 0 0 2 2 2 0 Torsin DAP3 PF10236.9 AIF82434.1 - 0.089 11.9 0.0 3 6.9 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 IPT PF01745.16 AIF82434.1 - 0.14 11.5 0.4 6.8 6.0 0.1 2.4 2 0 0 2 2 2 0 Isopentenyl transferase HSP20 PF00011.21 AIF82435.1 - 2.4e-08 34.0 3.4 6.1e-07 29.5 3.4 2.2 1 1 0 1 1 1 1 Hsp20/alpha crystallin family PIH1_CS PF18201.1 AIF82435.1 - 5.9e-07 29.8 0.1 9.7e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 PIH1 CS-like domain ArsA_HSP20 PF17886.1 AIF82435.1 - 3.4e-06 26.5 0.0 5.7e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 AIF82435.1 - 0.0068 17.4 1.3 0.045 14.8 0.3 2.1 2 0 0 2 2 2 1 CS domain GvpH PF05455.11 AIF82435.1 - 0.05 13.7 0.0 0.066 13.3 0.0 1.3 1 0 0 1 1 1 0 GvpH DUF3458 PF11940.8 AIF82435.1 - 0.1 13.0 0.1 0.17 12.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3458) Ig-like fold HTH_20 PF12840.7 AIF82436.1 - 2.2e-15 56.4 0.8 6.1e-15 55.0 0.0 2.1 3 0 0 3 3 2 1 Helix-turn-helix domain HTH_5 PF01022.20 AIF82436.1 - 7.9e-13 48.1 4.8 1.9e-12 46.8 0.0 2.9 3 0 0 3 3 3 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 AIF82436.1 - 1.5e-07 30.8 0.3 1.9e-06 27.3 0.1 2.8 2 1 0 2 2 2 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 AIF82436.1 - 9.1e-07 28.7 2.5 0.00073 19.4 0.0 3.1 3 0 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB PadR PF03551.14 AIF82436.1 - 1.4e-06 28.2 2.2 3.2e-05 23.8 0.4 3.1 2 1 0 2 2 2 1 Transcriptional regulator PadR-like family MarR_2 PF12802.7 AIF82436.1 - 4.7e-06 26.4 0.0 1.3e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 MarR family DprA_WH PF17782.1 AIF82436.1 - 5.2e-06 26.5 0.1 2.3e-05 24.4 0.1 2.0 2 0 0 2 2 1 1 DprA winged helix domain HTH_11 PF08279.12 AIF82436.1 - 5e-05 23.1 0.7 0.0007 19.5 0.1 2.9 3 0 0 3 3 3 1 HTH domain ArsR PF09824.9 AIF82436.1 - 5.4e-05 22.8 2.1 0.00033 20.3 0.2 2.2 1 1 0 2 2 2 1 ArsR transcriptional regulator MarR PF01047.22 AIF82436.1 - 8.3e-05 22.4 0.3 0.00077 19.3 0.1 2.4 2 0 0 2 2 2 1 MarR family HTH_12 PF08461.10 AIF82436.1 - 0.00046 20.1 0.1 0.0026 17.7 0.0 2.4 2 1 0 2 2 1 1 Ribonuclease R winged-helix domain HxlR PF01638.17 AIF82436.1 - 0.0019 18.0 0.5 0.0069 16.2 0.0 2.1 2 1 0 2 2 2 1 HxlR-like helix-turn-helix Rrf2 PF02082.20 AIF82436.1 - 0.0032 17.8 1.3 0.038 14.4 0.0 2.7 3 0 0 3 3 2 1 Transcriptional regulator HTH_IclR PF09339.10 AIF82436.1 - 0.0047 16.7 0.1 0.016 15.0 0.1 1.9 1 0 0 1 1 1 1 IclR helix-turn-helix domain DUF2250 PF10007.9 AIF82436.1 - 0.005 16.9 0.4 0.005 16.9 0.4 2.8 3 1 0 3 3 2 1 Uncharacterized protein conserved in archaea (DUF2250) HTH_27 PF13463.6 AIF82436.1 - 0.019 15.4 0.6 0.45 11.1 0.1 2.7 2 1 0 2 2 2 0 Winged helix DNA-binding domain DUF1759 PF03564.15 AIF82436.1 - 0.034 14.1 2.6 0.061 13.3 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) LexA_DNA_bind PF01726.16 AIF82436.1 - 0.071 12.9 0.1 0.36 10.6 0.0 2.1 2 0 0 2 2 2 0 LexA DNA binding domain Fe_dep_repress PF01325.19 AIF82436.1 - 0.081 13.1 1.5 0.66 10.2 0.0 2.6 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain SMC_ScpB PF04079.16 AIF82436.1 - 0.098 12.3 3.4 11 5.6 0.0 3.4 2 1 3 5 5 5 0 Segregation and condensation complex subunit ScpB HTH_7 PF02796.15 AIF82436.1 - 0.1 12.7 0.0 1 9.5 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase DUF2730 PF10805.8 AIF82436.1 - 0.11 12.6 3.2 0.12 12.5 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) CorA PF01544.18 AIF82436.1 - 0.13 11.5 5.8 0.87 8.8 5.8 2.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein CHDCT2 PF08074.11 AIF82436.1 - 0.14 12.3 2.5 0.15 12.3 0.7 1.9 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain FapA PF03961.13 AIF82436.1 - 0.38 9.3 4.8 0.52 8.9 4.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A SKA2 PF16740.5 AIF82436.1 - 0.39 10.5 7.0 0.47 10.2 3.4 2.5 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Syntaxin-6_N PF09177.11 AIF82436.1 - 0.59 10.7 5.5 0.27 11.8 1.0 2.4 2 1 1 3 3 3 0 Syntaxin 6, N-terminal Prefoldin_2 PF01920.20 AIF82436.1 - 1 9.3 8.6 0.39 10.7 0.4 3.0 2 1 1 3 3 3 0 Prefoldin subunit Fib_alpha PF08702.10 AIF82436.1 - 1.4 9.1 5.3 17 5.6 0.2 2.6 2 1 1 3 3 2 0 Fibrinogen alpha/beta chain family APG6_N PF17675.1 AIF82436.1 - 4.5 7.8 11.2 2.3 8.8 7.2 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region CLZ PF16526.5 AIF82436.1 - 5.7 7.4 9.9 2.8 8.4 0.6 3.1 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Cpn60_TCP1 PF00118.24 AIF82437.1 - 3.4e-177 590.0 17.8 4.1e-177 589.7 17.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Response_reg PF00072.24 AIF82438.1 - 4.3e-15 55.9 0.1 5.2e-15 55.6 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain HTH_24 PF13412.6 AIF82439.1 - 1.6e-06 27.5 1.8 3.1e-06 26.6 1.8 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF82439.1 - 0.00025 20.8 1.4 0.0006 19.6 1.4 1.7 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 AIF82439.1 - 0.019 15.0 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 Lrp/AsnC ligand binding domain HTH_11 PF08279.12 AIF82439.1 - 0.047 13.6 0.5 0.12 12.3 0.1 1.9 2 0 0 2 2 2 0 HTH domain TrmB PF01978.19 AIF82439.1 - 0.075 12.9 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 AIF82439.1 - 0.079 12.8 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_23 PF13384.6 AIF82439.1 - 0.092 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HisKA_3 PF07730.13 AIF82440.1 - 0.022 15.2 12.8 0.81 10.2 0.0 4.1 1 1 2 3 3 3 0 Histidine kinase TMP_2 PF06791.13 AIF82440.1 - 0.54 9.9 21.4 0.49 10.0 13.8 2.6 1 1 2 3 3 3 0 Prophage tail length tape measure protein Prominin PF05478.11 AIF82440.1 - 1.2 7.0 15.2 0.59 8.0 9.9 1.9 1 1 1 2 2 2 0 Prominin DUF948 PF06103.11 AIF82440.1 - 2.9 8.2 19.7 12 6.3 4.0 3.8 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Syntaxin_2 PF14523.6 AIF82440.1 - 5.9 7.3 19.9 4.1 7.8 0.3 3.2 1 1 2 3 3 3 0 Syntaxin-like protein REF PF05755.12 AIF82440.1 - 7.8 6.3 19.8 19 5.0 10.2 3.1 1 1 2 3 3 3 0 Rubber elongation factor protein (REF) DUF2203 PF09969.9 AIF82440.1 - 7.9 7.2 17.3 2.9 8.6 3.2 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF1056 PF06341.11 AIF82441.1 - 0.088 13.1 2.6 0.11 12.8 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1056) DUF4282 PF14110.6 AIF82441.1 - 0.13 13.0 4.6 0.18 12.6 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) SurA_N_3 PF13624.6 AIF82442.1 - 0.0044 16.8 0.6 0.0048 16.7 0.6 1.0 1 0 0 1 1 1 1 SurA N-terminal domain PepSY PF03413.19 AIF82444.1 - 1.1e-10 41.9 4.8 6.7e-07 29.8 0.8 2.3 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain DUF4292 PF14125.6 AIF82444.1 - 0.19 11.4 0.0 0.37 10.4 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4292) PepSY_2 PF13670.6 AIF82444.1 - 0.2 11.6 2.5 2.5 8.2 0.0 3.0 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain Apolipoprotein PF01442.18 AIF82446.1 - 0.011 15.7 0.3 0.016 15.1 0.3 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain PaaA_PaaC PF05138.12 AIF82446.1 - 0.026 13.7 0.2 0.029 13.5 0.2 1.0 1 0 0 1 1 1 0 Phenylacetic acid catabolic protein GlutR_dimer PF00745.20 AIF82446.1 - 0.028 14.9 0.3 2.8 8.4 0.1 2.0 1 1 1 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Phasin PF05597.11 AIF82446.1 - 0.047 13.7 0.2 0.06 13.3 0.2 1.3 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4358 PF14270.6 AIF82446.1 - 0.061 13.6 0.2 0.12 12.6 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4358) YqzH PF14164.6 AIF82446.1 - 0.062 13.4 0.1 0.13 12.3 0.0 1.5 1 1 0 1 1 1 0 YqzH-like protein DUF4995 PF16386.5 AIF82446.1 - 0.13 12.3 0.0 0.16 12.0 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function zf-CCHC_4 PF14392.6 AIF82448.1 - 0.17 11.7 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Zinc knuckle NitrOD2 PF18550.1 AIF82449.1 - 5.2e-30 103.7 0.2 1.6e-29 102.1 0.1 1.7 2 0 0 2 2 2 1 Nitrososphaera output domain 2 Response_reg PF00072.24 AIF82449.1 - 3.4e-19 69.1 0.6 5.7e-19 68.3 0.6 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Delta_lysin PF05372.11 AIF82449.1 - 0.12 11.6 0.1 0.3 10.4 0.1 1.6 1 0 0 1 1 1 0 Delta lysin family PepSY PF03413.19 AIF82450.1 - 1.1e-07 32.3 0.4 2e-07 31.5 0.4 1.5 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain DUF1980 PF09323.10 AIF82450.1 - 0.01 15.8 0.1 0.015 15.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) TERB2 PF15101.6 AIF82450.1 - 0.055 13.5 0.4 0.076 13.1 0.4 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Pneumo_att_G PF05539.11 AIF82450.1 - 0.1 12.2 3.4 0.13 11.8 3.4 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DUF2749 PF10907.8 AIF82450.1 - 0.16 12.1 0.5 0.4 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) DUF3750 PF12570.8 AIF82451.1 - 0.0033 18.1 0.0 0.011 16.4 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3750) HATPase_c PF02518.26 AIF82452.1 - 1.3e-23 83.6 1.7 2.6e-23 82.7 0.3 2.2 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 AIF82452.1 - 5.8e-20 72.1 2.9 1e-19 71.3 2.6 1.5 1 1 0 1 1 1 1 Cache domain HisKA PF00512.25 AIF82452.1 - 1.9e-12 47.0 0.1 6.6e-12 45.3 0.1 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 AIF82452.1 - 0.013 15.4 0.0 0.11 12.4 0.0 2.4 2 1 0 2 2 2 0 GHKL domain HATPase_c_3 PF13589.6 AIF82452.1 - 0.019 14.8 0.2 0.057 13.3 0.1 1.8 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sec34 PF04136.15 AIF82452.1 - 0.032 14.1 0.5 0.06 13.2 0.0 1.7 2 0 0 2 2 2 0 Sec34-like family CREPT PF16566.5 AIF82452.1 - 0.074 13.2 0.3 0.17 12.0 0.3 1.6 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Spc7 PF08317.11 AIF82452.1 - 0.086 11.7 1.5 0.14 11.0 1.5 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.11 AIF82452.1 - 0.13 12.3 0.7 0.48 10.5 0.2 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ZapB PF06005.12 AIF82452.1 - 4.3 7.8 6.4 2.1 8.8 3.3 2.0 2 0 0 2 2 2 0 Cell division protein ZapB GHMP_kinases_C PF08544.13 AIF82452.1 - 5.1 7.5 5.4 0.87 10.0 0.3 2.5 3 1 0 3 3 3 0 GHMP kinases C terminal Vps39_2 PF10367.9 AIF82454.1 - 0.022 15.2 0.3 0.03 14.8 0.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 CpXC PF14353.6 AIF82454.1 - 0.036 14.1 0.4 0.073 13.1 0.1 1.7 1 1 0 2 2 2 0 CpXC protein NOB1_Zn_bind PF08772.11 AIF82454.1 - 0.048 13.8 0.1 0.061 13.5 0.1 1.2 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_10 PF10058.9 AIF82454.1 - 0.24 11.2 2.4 0.99 9.2 2.5 1.9 1 1 1 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein p450 PF00067.22 AIF82455.1 - 1.7e-40 139.2 0.0 2.8e-40 138.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Cdh1_DBD_1 PF18196.1 AIF82455.1 - 0.054 13.8 0.7 0.13 12.6 0.7 1.5 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Endotoxin_N PF03945.14 AIF82455.1 - 0.13 12.0 0.4 3.1 7.5 0.2 2.3 2 0 0 2 2 2 0 delta endotoxin, N-terminal domain CopG_antitoxin PF12441.8 AIF82456.1 - 0.01 16.4 0.1 0.013 16.0 0.1 1.1 1 0 0 1 1 1 0 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIF82456.1 - 0.015 15.1 0.1 0.02 14.7 0.1 1.2 1 0 0 1 1 1 0 HicB family Nitro_FeMo-Co PF02579.17 AIF82457.1 - 0.047 14.0 0.0 0.047 14.0 0.0 1.0 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor AmoC PF04896.12 AIF82458.1 - 4.7e-14 52.3 5.6 5.5e-14 52.0 5.6 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C RTA1 PF04479.13 AIF82458.1 - 0.0048 16.5 0.3 0.0082 15.8 0.3 1.3 1 0 0 1 1 1 1 RTA1 like protein PDR_CDR PF06422.12 AIF82458.1 - 0.054 13.4 0.5 2 8.4 0.8 2.3 2 0 0 2 2 2 0 CDR ABC transporter Fer4_7 PF12838.7 AIF82459.1 - 1.2e-09 38.6 2.7 0.00022 21.7 0.7 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 AIF82459.1 - 2.9e-09 36.3 12.9 3.2e-06 26.7 2.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 AIF82459.1 - 8e-08 32.3 6.6 2.7e-06 27.4 7.2 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 AIF82459.1 - 1.7e-06 28.1 7.0 3.8e-05 23.8 8.1 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIF82459.1 - 5.3e-06 27.3 5.1 0.0033 18.3 0.5 2.5 3 0 0 3 3 2 2 4Fe-4S double cluster binding domain Fer4_8 PF13183.6 AIF82459.1 - 5.4e-06 26.8 5.7 0.0011 19.4 8.2 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIF82459.1 - 7.8e-06 25.7 12.5 0.0056 16.7 1.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 AIF82459.1 - 2e-05 25.0 7.2 0.011 16.3 0.4 2.6 3 0 0 3 3 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_21 PF14697.6 AIF82459.1 - 3.8e-05 23.7 9.5 0.0074 16.4 9.7 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 AIF82459.1 - 0.00013 22.4 4.7 0.003 18.1 6.3 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIF82459.1 - 0.00029 20.7 10.6 0.055 13.6 3.6 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 AIF82459.1 - 0.00053 20.3 6.6 0.049 14.1 1.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 AIF82459.1 - 0.0012 19.5 7.7 0.037 14.8 2.1 2.6 2 1 0 2 2 2 2 4Fe-4S single cluster domain Fer4_22 PF17179.4 AIF82459.1 - 0.0027 18.5 0.2 2.7 8.9 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_18 PF13746.6 AIF82459.1 - 0.0052 17.0 8.1 0.086 13.0 5.8 2.3 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIF82459.1 - 0.03 15.2 13.9 1.4 10.0 0.8 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 AIF82459.1 - 0.24 11.6 3.7 0.84 9.8 0.1 2.4 1 1 0 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S NapD PF03927.13 AIF82460.1 - 9.3e-07 28.8 0.0 1.2e-06 28.5 0.0 1.0 1 0 0 1 1 1 1 NapD protein AsnC_trans_reg PF01037.21 AIF82460.1 - 2.5e-06 27.4 0.0 2.8e-06 27.2 0.0 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HMA PF00403.26 AIF82460.1 - 0.016 15.6 0.1 0.02 15.3 0.1 1.1 1 0 0 1 1 1 0 Heavy-metal-associated domain AsnC_trans_reg2 PF17805.1 AIF82460.1 - 0.12 12.5 0.0 0.18 11.9 0.0 1.3 1 1 0 1 1 1 0 AsnC-like ligand binding domain Ribosomal_L37e PF01907.19 AIF82461.1 - 0.68 10.1 17.1 0.4 10.9 2.3 2.7 1 1 2 3 3 3 0 Ribosomal protein L37e zf-C2H2_4 PF13894.6 AIF82461.1 - 1.7 9.7 0.1 1.7 9.7 0.1 4.2 4 1 1 5 5 5 0 C2H2-type zinc finger DUF2797 PF10977.8 AIF82461.1 - 3.2 7.6 11.2 0.49 10.2 4.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2797) XPA_N PF01286.18 AIF82461.1 - 9.9 6.3 9.6 1.5 8.9 2.1 3.0 2 1 0 2 2 2 0 XPA protein N-terminal Polyketide_cyc2 PF10604.9 AIF82465.1 - 1.8e-10 41.3 0.0 2e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIF82465.1 - 0.00013 22.1 0.0 0.00022 21.4 0.0 1.5 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF4533 PF15047.6 AIF82466.1 - 0.12 12.0 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) DUF2204 PF09970.9 AIF82467.1 - 0.16 11.6 0.1 0.19 11.4 0.1 1.1 1 0 0 1 1 1 0 Nucleotidyl transferase of unknown function (DUF2204) HTH_24 PF13412.6 AIF82468.1 - 0.00075 19.0 1.3 0.0025 17.4 0.2 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Mga PF05043.13 AIF82468.1 - 0.0081 16.7 0.1 0.021 15.4 0.1 1.7 1 0 0 1 1 1 1 Mga helix-turn-helix domain HTH_11 PF08279.12 AIF82468.1 - 0.015 15.2 1.0 0.051 13.5 0.3 2.1 2 0 0 2 2 2 0 HTH domain HTH_AsnC-type PF13404.6 AIF82468.1 - 0.016 15.1 0.1 0.038 13.8 0.1 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_psq PF05225.16 AIF82468.1 - 0.029 14.1 0.0 0.063 13.0 0.0 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain DUF2151 PF10221.9 AIF82468.1 - 0.069 11.7 0.0 0.091 11.3 0.0 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator HTH_23 PF13384.6 AIF82468.1 - 0.1 12.4 0.0 0.29 11.0 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain Pilin_N PF07790.11 AIF82470.1 - 0.00013 22.8 4.1 0.00019 22.3 4.1 1.2 1 0 0 1 1 1 1 Archaeal Type IV pilin, N-terminal DUF5337 PF17272.2 AIF82470.1 - 0.04 13.7 1.4 0.8 9.6 0.2 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5337) Na_H_Exchanger PF00999.21 AIF82471.1 - 1.1e-54 185.7 52.2 1.5e-54 185.3 52.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family PGA2 PF07543.12 AIF82471.1 - 0.12 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 zf-C2HC_2 PF13913.6 AIF82472.1 - 0.0062 16.4 0.2 0.019 14.9 0.0 1.8 2 0 0 2 2 2 1 zinc-finger of a C2HC-type LPD39 PF18858.1 AIF82472.1 - 0.022 14.8 1.6 0.042 13.9 0.2 1.9 2 1 0 2 2 2 0 Large polyvalent protein associated domain 39 IcmF-related PF06761.12 AIF82472.1 - 0.037 13.5 0.2 0.041 13.4 0.2 1.1 1 0 0 1 1 1 0 Intracellular multiplication and human macrophage-killing zf-C2H2_4 PF13894.6 AIF82472.1 - 0.039 14.8 0.9 0.096 13.6 0.2 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger Actin_micro PF17003.5 AIF82472.1 - 0.048 12.8 0.5 0.053 12.7 0.5 1.2 1 0 0 1 1 1 0 Putative actin-like family Senescence PF06911.12 AIF82472.1 - 0.11 12.8 0.0 1.5 9.1 0.0 2.0 1 1 1 2 2 2 0 Senescence-associated protein zf-C2H2_11 PF16622.5 AIF82472.1 - 0.12 12.1 1.2 0.29 10.9 1.2 1.5 1 0 0 1 1 1 0 zinc-finger C2H2-type 4HB_MCP_1 PF12729.7 AIF82473.1 - 1e-16 61.0 13.6 1.1e-10 41.4 1.2 2.6 3 0 0 3 3 3 2 Four helix bundle sensory module for signal transduction DUF835 PF05763.12 AIF82473.1 - 2e-10 40.5 1.0 7.6e-10 38.6 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF835) CCDC24 PF15669.5 AIF82473.1 - 0.1 12.4 6.7 0.024 14.5 2.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family TarH PF02203.15 AIF82473.1 - 0.45 10.4 9.9 0.17 11.8 0.4 2.6 3 0 0 3 3 3 0 Tar ligand binding domain homologue PAP1 PF08601.10 AIF82473.1 - 1.4 8.5 10.2 3.1 7.4 10.2 1.6 1 0 0 1 1 1 0 Transcription factor PAP1 ATPase PF06745.13 AIF82474.1 - 3.9e-46 157.2 0.1 4.8e-46 157.0 0.1 1.0 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.6 AIF82474.1 - 1e-10 41.5 0.1 1.3e-09 38.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 AIF82474.1 - 1.2e-07 31.4 0.0 2.3e-07 30.4 0.0 1.6 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_18 PF13238.6 AIF82474.1 - 0.00059 20.4 0.1 0.0014 19.2 0.1 1.6 1 1 0 1 1 1 1 AAA domain GvpD PF07088.11 AIF82474.1 - 0.0035 16.0 0.1 0.044 12.4 0.1 2.0 1 1 0 1 1 1 1 GvpD gas vesicle protein Rad51 PF08423.11 AIF82474.1 - 0.0071 15.6 0.0 0.0089 15.3 0.0 1.3 1 1 0 1 1 1 1 Rad51 NACHT PF05729.12 AIF82474.1 - 0.011 15.6 0.1 0.074 13.0 0.1 2.0 1 1 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 AIF82474.1 - 0.012 15.8 0.0 0.018 15.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain RecA PF00154.21 AIF82474.1 - 0.014 14.9 0.0 0.031 13.7 0.0 1.7 1 1 0 1 1 1 0 recA bacterial DNA recombination protein AAA_16 PF13191.6 AIF82474.1 - 0.02 15.3 0.0 0.054 13.9 0.0 1.8 1 1 1 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 AIF82474.1 - 0.02 15.1 0.0 0.037 14.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AIF82474.1 - 0.023 14.4 0.2 0.06 13.1 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 AIF82474.1 - 0.024 15.1 0.3 0.072 13.5 0.3 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Fibrillarin PF01269.17 AIF82474.1 - 0.041 13.0 0.0 0.12 11.5 0.0 1.6 1 1 1 2 2 2 0 Fibrillarin IstB_IS21 PF01695.17 AIF82474.1 - 0.075 12.8 0.0 0.21 11.3 0.0 1.8 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_29 PF13555.6 AIF82474.1 - 0.081 12.7 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ras PF00071.22 AIF82474.1 - 0.15 11.6 0.0 2.9 7.5 0.0 2.2 1 1 1 2 2 2 0 Ras family HemN_C PF06969.16 AIF82474.1 - 0.16 12.0 0.1 0.48 10.5 0.0 1.8 2 0 0 2 2 2 0 HemN C-terminal domain MEDS PF14417.6 AIF82476.1 - 3.7e-17 62.6 0.1 5.6e-17 62.0 0.1 1.3 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain ATPase PF06745.13 AIF82476.1 - 0.00024 20.5 0.2 0.00052 19.4 0.1 1.5 1 1 1 2 2 2 1 KaiC Cohesin_HEAT PF12765.7 AIF82476.1 - 0.097 13.0 0.1 0.41 11.0 0.1 2.1 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion DUF4149 PF13664.6 AIF82477.1 - 0.84 10.0 8.7 0.046 14.0 1.9 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) zinc_ribbon_2 PF13240.6 AIF82479.1 - 1.4e-07 31.0 3.5 2.2e-07 30.3 3.5 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 AIF82479.1 - 0.00015 21.7 2.8 0.00027 20.9 2.8 1.4 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 AIF82479.1 - 0.00023 21.9 0.1 0.00045 20.9 0.1 1.6 1 0 0 1 1 1 1 zinc-ribbon family ASFV_p27 PF06556.11 AIF82479.1 - 0.00035 20.7 0.3 0.00071 19.7 0.2 1.6 2 0 0 2 2 2 1 IAP-like protein p27 C-terminus zf-ribbon_3 PF13248.6 AIF82479.1 - 0.00045 19.5 2.8 0.00076 18.8 2.8 1.4 1 0 0 1 1 1 1 zinc-ribbon domain UPF0547 PF10571.9 AIF82479.1 - 0.01 15.9 4.0 0.018 15.1 4.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 DUF2116 PF09889.9 AIF82479.1 - 0.062 13.3 1.4 0.11 12.4 1.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DHHC PF01529.20 AIF82479.1 - 0.065 13.3 1.1 0.12 12.5 1.1 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase zf-RRN7 PF11781.8 AIF82479.1 - 0.13 12.0 2.9 1.1 9.0 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Nudix_N_2 PF14803.6 AIF82479.1 - 0.29 11.1 5.2 3.8 7.5 1.1 2.5 2 0 0 2 2 2 0 Nudix N-terminal YhfH PF14149.6 AIF82479.1 - 0.79 9.8 3.8 2.8 8.0 0.2 2.3 1 1 1 2 2 2 0 YhfH-like protein BUD22 PF09073.10 AIF82481.1 - 0.18 11.1 27.7 0.28 10.5 27.7 1.2 1 0 0 1 1 1 0 BUD22 Prenyltransf PF01255.19 AIF82482.1 - 4.9e-69 232.3 0.3 5.8e-69 232.0 0.3 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Adenine_glyco PF03352.13 AIF82482.1 - 0.011 15.5 0.2 0.018 14.8 0.2 1.3 1 0 0 1 1 1 0 Methyladenine glycosylase Asp_Glu_race PF01177.22 AIF82483.1 - 3.3e-22 79.5 0.0 4.2e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Polysacc_deac_1 PF01522.21 AIF82485.1 - 3.2e-10 40.0 0.0 6.8e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Big_7 PF17957.1 AIF82485.1 - 1.5e-05 25.7 5.5 2.3e-05 25.0 4.1 2.0 1 1 1 2 2 2 1 Bacterial Ig domain DUF2334 PF10096.9 AIF82485.1 - 4.8e-05 23.1 0.0 7.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) SDA1 PF05285.12 AIF82485.1 - 0.63 9.4 12.4 0.8 9.1 12.4 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 AIF82485.1 - 1.7 6.9 10.4 2.3 6.4 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein CtsR PF05848.11 AIF82488.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 CtsR N-terminal HTH domain Snf7 PF03357.21 AIF82492.1 - 0.004 16.8 1.9 0.004 16.8 1.9 1.5 2 0 0 2 2 2 1 Snf7 KASH_CCD PF14662.6 AIF82492.1 - 0.023 14.5 1.9 0.041 13.7 1.9 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DASH_Duo1 PF08651.10 AIF82492.1 - 0.13 12.1 0.9 0.35 10.7 0.1 2.1 2 0 0 2 2 2 0 DASH complex subunit Duo1 CENP-F_leu_zip PF10473.9 AIF82492.1 - 0.14 12.2 2.4 0.25 11.4 2.4 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.6 AIF82492.1 - 0.16 10.6 0.6 0.18 10.4 0.6 1.1 1 0 0 1 1 1 0 AAA domain Pex19 PF04614.12 AIF82492.1 - 9 6.0 8.6 0.83 9.4 1.2 2.1 1 1 1 2 2 2 0 Pex19 protein family SPC12 PF06645.13 AIF82493.1 - 0.13 12.4 4.6 3.3 7.8 0.6 2.2 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) TP_methylase PF00590.20 AIF82494.1 - 4.4e-47 160.8 2.0 4.7e-47 160.7 0.9 1.5 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TP_methylase PF00590.20 AIF82495.1 - 9.3e-53 179.3 0.4 1.1e-52 179.0 0.4 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Radical_SAM PF04055.21 AIF82495.1 - 0.068 13.5 0.0 0.13 12.7 0.0 1.5 1 1 0 1 1 1 0 Radical SAM superfamily HTH_OrfB_IS605 PF12323.8 AIF82496.1 - 1.8e-11 43.3 1.6 2.7e-11 42.8 0.2 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain OrfB_IS605 PF01385.19 AIF82496.1 - 0.0014 18.8 0.1 0.003 17.8 0.1 1.5 1 0 0 1 1 1 1 Probable transposase OrfB_Zn_ribbon PF07282.11 AIF82497.1 - 9.5e-21 73.5 0.4 1.7e-20 72.7 0.2 1.5 2 0 0 2 2 2 1 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 AIF82497.1 - 3.3e-05 23.1 1.1 0.061 12.8 0.1 2.4 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 AIF82497.1 - 0.00032 20.7 0.3 0.00054 19.9 0.3 1.4 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 AIF82497.1 - 0.00041 20.3 0.0 0.00062 19.8 0.0 1.2 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_UBZ PF18439.1 AIF82497.1 - 0.00069 19.2 2.1 0.061 12.9 0.2 2.3 1 1 1 2 2 2 2 Ubiquitin-Binding Zinc Finger TF_Zn_Ribbon PF08271.12 AIF82497.1 - 0.0042 16.6 1.0 0.045 13.3 1.1 2.1 1 1 1 2 2 2 1 TFIIB zinc-binding zf-ISL3 PF14690.6 AIF82497.1 - 0.0048 17.5 3.9 1.9 9.2 0.0 3.2 3 0 0 3 3 3 2 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Rpr2 PF04032.16 AIF82497.1 - 0.0055 17.0 1.3 2.8 8.3 0.0 2.3 1 1 1 2 2 2 2 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-NADH-PPase PF09297.11 AIF82497.1 - 0.0057 16.3 3.1 0.014 15.1 3.1 1.7 1 1 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 AIF82497.1 - 0.011 15.4 5.0 0.68 9.7 0.1 2.5 3 0 0 3 3 2 0 zinc-ribbon domain Nudix_N_2 PF14803.6 AIF82497.1 - 0.013 15.4 6.5 0.1 12.5 2.5 3.1 2 1 0 2 2 2 0 Nudix N-terminal Zn-ribbon_8 PF09723.10 AIF82497.1 - 0.018 15.2 1.9 0.044 13.9 1.9 1.7 1 1 0 1 1 1 0 Zinc ribbon domain FYVE PF01363.21 AIF82497.1 - 0.03 14.4 0.1 0.039 14.1 0.1 1.3 1 0 0 1 1 1 0 FYVE zinc finger zinc_ribbon_4 PF13717.6 AIF82497.1 - 0.031 14.2 0.4 4.6 7.2 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain TackOD1 PF18551.1 AIF82497.1 - 0.037 13.7 0.1 0.044 13.4 0.1 1.3 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Zn_Tnp_IS91 PF14319.6 AIF82497.1 - 0.038 14.0 0.1 0.061 13.4 0.1 1.5 1 0 0 1 1 1 0 Transposase zinc-binding domain CpXC PF14353.6 AIF82497.1 - 0.062 13.4 0.5 0.9 9.6 0.0 2.4 1 1 2 3 3 3 0 CpXC protein zf_C2H2_13 PF18508.1 AIF82497.1 - 0.15 11.7 1.6 5.6 6.7 0.2 2.5 1 1 1 2 2 2 0 Zinc finger domain Auto_anti-p27 PF06677.12 AIF82497.1 - 0.26 11.5 2.3 0.51 10.5 0.1 2.2 1 1 1 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-Mss51 PF13824.6 AIF82497.1 - 0.49 10.5 4.2 2.5 8.3 0.2 2.6 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-dskA_traR PF01258.17 AIF82497.1 - 1.1 9.2 3.7 1.9 8.5 0.1 2.8 2 1 1 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger A2L_zn_ribbon PF08792.10 AIF82497.1 - 1.1 9.0 3.4 5.8 6.7 0.0 2.6 3 0 0 3 3 3 0 A2L zinc ribbon domain zf-ACC PF17848.1 AIF82497.1 - 2.2 8.4 4.5 23 5.2 4.7 2.3 1 1 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain DnaJ PF00226.31 AIF82498.1 - 1.2e-24 86.2 1.0 2.5e-24 85.2 1.0 1.6 1 0 0 1 1 1 1 DnaJ domain Fer4_13 PF13370.6 AIF82498.1 - 3.6e-07 30.6 0.2 3.6e-07 30.6 0.2 2.4 2 1 0 2 2 2 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 AIF82498.1 - 1.1e-05 26.0 2.6 1.6e-05 25.5 0.2 2.2 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_19 PF06902.11 AIF82498.1 - 0.0001 22.3 0.1 0.00028 20.9 0.1 1.8 1 0 0 1 1 1 1 Divergent 4Fe-4S mono-cluster SabA_adhesion PF18304.1 AIF82498.1 - 0.013 14.8 2.3 0.019 14.2 2.3 1.1 1 0 0 1 1 1 0 SabA N-terminal extracellular adhesion domain DUF1068 PF06364.12 AIF82498.1 - 0.027 14.4 1.4 0.041 13.7 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) Vac17 PF17321.2 AIF82499.1 - 0.066 12.7 0.5 0.078 12.4 0.5 1.1 1 0 0 1 1 1 0 Vacuole-related protein 17 HD_4 PF13328.6 AIF82500.1 - 4.1e-19 68.8 5.2 5.2e-19 68.5 5.2 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.22 AIF82500.1 - 2.1e-06 28.0 1.8 6e-06 26.5 0.7 2.3 2 1 0 2 2 2 1 HD domain SIMPL PF04402.14 AIF82501.1 - 1.8e-42 146.1 8.2 2.3e-42 145.7 8.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF541) HMGL-like PF00682.19 AIF82501.1 - 0.0082 15.7 0.4 0.011 15.3 0.4 1.2 1 0 0 1 1 1 1 HMGL-like Helveticin_J PF17312.2 AIF82501.1 - 0.0091 15.1 0.5 0.011 14.9 0.5 1.2 1 0 0 1 1 1 1 Bacteriocin helveticin-J DUF1657 PF07870.11 AIF82501.1 - 0.0098 15.8 0.6 0.02 14.8 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1657) M20_dimer PF07687.14 AIF82501.1 - 0.1 12.5 0.1 0.42 10.6 0.0 1.9 2 0 0 2 2 2 0 Peptidase dimerisation domain PRIMA1 PF16101.5 AIF82501.1 - 0.13 12.3 2.2 0.22 11.5 2.2 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Rotamase_3 PF13616.6 AIF82503.1 - 8.1e-27 94.1 0.1 1.3e-26 93.4 0.1 1.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 AIF82503.1 - 7.4e-25 87.7 0.1 8.8e-25 87.5 0.1 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 AIF82503.1 - 5.5e-10 40.1 0.0 6.3e-10 39.9 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Get5_C PF18514.1 AIF82503.1 - 0.049 13.4 0.0 0.081 12.7 0.0 1.4 1 0 0 1 1 1 0 Get5 C-terminal domain NTPase_I-T PF01931.18 AIF82503.1 - 0.13 12.0 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF84 PTS-HPr PF00381.19 AIF82505.1 - 0.037 14.3 0.0 0.1 12.9 0.0 1.8 1 0 0 1 1 1 0 PTS HPr component phosphorylation site Gln-synt_C PF00120.24 AIF82506.1 - 1.9e-116 388.9 0.0 2.2e-116 388.6 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 AIF82506.1 - 9.5e-25 86.1 0.0 2.8e-24 84.6 0.0 1.9 2 0 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain AA_synth PF06684.11 AIF82506.1 - 0.065 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Amino acid synthesis DUF3042 PF11240.8 AIF82508.1 - 0.044 13.8 0.5 0.43 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) RseC_MucC PF04246.12 AIF82508.1 - 0.055 13.4 1.5 0.061 13.3 1.5 1.2 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC DUF4257 PF14074.6 AIF82509.1 - 0.14 12.4 5.1 1.7 8.9 1.8 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4257) YqhR PF11085.8 AIF82509.1 - 0.18 11.7 8.3 3.8 7.4 7.7 2.2 1 1 0 1 1 1 0 Conserved membrane protein YqhR DUF1440 PF07274.12 AIF82509.1 - 0.41 11.0 6.4 0.18 12.1 3.1 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1440) TfoX_N PF04993.13 AIF82510.1 - 2.2e-13 50.2 0.0 2.6e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 TfoX N-terminal domain adh_short PF00106.25 AIF82512.1 - 2.3e-65 219.7 1.4 3e-65 219.4 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIF82512.1 - 1.7e-51 175.0 2.4 2.1e-51 174.7 2.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIF82512.1 - 1.2e-13 51.4 0.4 1.9e-13 50.7 0.4 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 AIF82512.1 - 6.8e-05 22.4 0.0 9e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 AIF82512.1 - 0.0003 20.3 0.3 0.0043 16.6 0.3 2.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 AIF82512.1 - 0.0055 16.0 0.8 0.036 13.4 0.1 2.5 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.6 AIF82512.1 - 0.0084 16.0 1.8 0.016 15.1 1.8 1.5 1 1 0 1 1 1 1 NAD(P)H-binding DEAD PF00270.29 AIF82512.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase IgG_binding_B PF01378.17 AIF82513.1 - 0.027 14.5 0.1 0.042 13.9 0.1 1.4 1 0 0 1 1 1 0 B domain Pyr_redox_2 PF07992.14 AIF82514.1 - 6.3e-22 78.2 0.0 1.5e-21 76.9 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AIF82514.1 - 1.2e-06 28.9 0.0 0.014 15.9 0.1 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AIF82514.1 - 0.00016 21.9 0.1 0.00036 20.7 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AIF82514.1 - 0.0011 18.6 0.1 0.047 13.3 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 AIF82514.1 - 0.0023 16.7 0.0 0.08 11.6 0.1 2.3 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 AIF82514.1 - 0.0088 15.2 0.0 0.059 12.4 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 AIF82514.1 - 0.024 14.6 0.1 0.19 11.7 0.1 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.17 AIF82514.1 - 0.032 13.5 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Thi4 family DUF2505 PF10698.9 AIF82514.1 - 0.08 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2505) Trp_halogenase PF04820.14 AIF82514.1 - 0.2 10.5 0.0 0.42 9.4 0.1 1.5 2 0 0 2 2 2 0 Tryptophan halogenase AbrB PF05145.12 AIF82515.1 - 0.0023 17.0 1.2 0.0037 16.3 1.2 1.2 1 0 0 1 1 1 1 Transition state regulatory protein AbrB Abhydrolase_9_N PF15420.6 AIF82515.1 - 0.012 15.7 2.7 0.013 15.5 2.7 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DUF4153 PF13687.6 AIF82515.1 - 0.015 14.9 6.3 0.034 13.8 1.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4153) Na_K-ATPase PF00287.18 AIF82515.1 - 0.16 11.1 1.1 0.25 10.5 1.1 1.2 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain DctQ PF04290.12 AIF82515.1 - 2.1 8.2 13.6 14 5.6 4.3 2.5 1 1 1 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component DHHC PF01529.20 AIF82515.1 - 9.9 6.3 8.2 1.3e+02 2.6 7.4 2.3 1 1 1 2 2 2 0 DHHC palmitoyltransferase DNA_pol_B_thumb PF14791.6 AIF82516.1 - 8e-22 77.2 0.2 2.4e-21 75.6 0.1 2.0 2 0 0 2 2 2 1 DNA polymerase beta thumb HHH_8 PF14716.6 AIF82516.1 - 1.5e-16 60.5 10.3 2.1e-16 60.0 0.5 3.6 5 0 0 5 5 5 1 Helix-hairpin-helix domain HHH_5 PF14520.6 AIF82516.1 - 5.3e-10 39.8 5.0 1.7e-06 28.6 2.0 3.2 2 0 0 2 2 2 2 Helix-hairpin-helix domain HHH PF00633.23 AIF82516.1 - 2.8e-07 30.1 1.1 0.002 17.9 0.1 3.4 3 0 0 3 3 3 2 Helix-hairpin-helix motif PHP PF02811.19 AIF82516.1 - 1e-06 29.1 0.1 2.7e-06 27.8 0.1 1.8 1 0 0 1 1 1 1 PHP domain HHH_3 PF12836.7 AIF82516.1 - 8.9e-05 22.7 0.4 0.27 11.5 0.0 3.4 2 1 1 3 3 3 2 Helix-hairpin-helix motif RNase_P_p30 PF01876.16 AIF82516.1 - 0.00044 19.8 0.1 0.0042 16.6 0.0 2.3 1 1 1 2 2 2 1 RNase P subunit p30 HHH_2 PF12826.7 AIF82516.1 - 0.0025 17.9 0.0 0.49 10.5 0.0 2.9 1 1 1 2 2 2 1 Helix-hairpin-helix motif DNA_pol_B_palm PF14792.6 AIF82516.1 - 0.0052 17.0 0.0 0.015 15.5 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta palm Cdd1 PF11731.8 AIF82516.1 - 0.068 13.4 0.1 2.8 8.3 0.0 2.9 1 1 1 2 2 2 0 Pathogenicity locus IMS_HHH PF11798.8 AIF82516.1 - 0.49 10.8 1.9 53 4.4 0.1 3.3 3 0 0 3 3 3 0 IMS family HHH motif TFIIB PF00382.19 AIF82518.1 - 1.1e-25 89.4 1.1 1.8e-12 47.1 0.0 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIF82518.1 - 3e-07 29.8 0.4 6.5e-07 28.8 0.4 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Sigma70_r4 PF04545.16 AIF82518.1 - 0.0036 16.8 0.4 0.16 11.5 0.0 3.2 3 0 0 3 3 3 1 Sigma-70, region 4 HTH_AsnC-type PF13404.6 AIF82518.1 - 0.015 15.1 0.2 2.6 7.9 0.0 3.2 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain Cyclin_C PF02984.19 AIF82518.1 - 0.03 14.4 0.2 1.5 8.9 0.0 2.6 2 1 0 2 2 2 0 Cyclin, C-terminal domain zf-ribbon_3 PF13248.6 AIF82518.1 - 0.1 12.0 2.8 1.5 8.3 2.8 2.3 1 1 0 1 1 1 0 zinc-ribbon domain Ribosomal_S27e PF01667.17 AIF82518.1 - 0.1 12.3 0.4 0.22 11.3 0.4 1.4 1 0 0 1 1 1 0 Ribosomal protein S27 HTH_3 PF01381.22 AIF82518.1 - 0.15 12.1 0.3 6.3 6.9 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix Rrf2 PF02082.20 AIF82518.1 - 0.24 11.8 1.2 12 6.3 0.0 3.2 3 1 1 4 4 4 0 Transcriptional regulator PTS_EIIC PF02378.18 AIF82519.1 - 0.0041 16.2 1.1 0.0042 16.2 1.1 1.0 1 0 0 1 1 1 1 Phosphotransferase system, EIIC RecX PF02631.16 AIF82520.1 - 0.045 14.2 0.3 0.069 13.6 0.3 1.4 1 0 0 1 1 1 0 RecX family dCMP_cyt_deam_1 PF00383.23 AIF82521.1 - 3.4e-25 87.9 1.0 4.2e-25 87.5 1.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AIF82521.1 - 3.5e-17 62.4 0.0 4.1e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC_N PF08210.11 AIF82521.1 - 0.017 15.0 0.2 0.082 12.8 0.2 1.9 1 1 0 1 1 1 0 APOBEC-like N-terminal domain SNAD4 PF18750.1 AIF82521.1 - 0.028 14.5 0.3 0.05 13.7 0.3 1.5 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 AIF82521.1 - 0.083 13.0 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 Acetyltransf_1 PF00583.25 AIF82523.1 - 4.4e-14 52.7 0.0 8.2e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 AIF82523.1 - 3.6e-09 37.4 0.2 8.8e-09 36.2 0.1 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AIF82523.1 - 2.6e-06 27.4 0.0 1e-05 25.5 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AIF82523.1 - 4.2e-06 27.1 0.0 8.7e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AIF82523.1 - 5e-05 23.4 0.4 0.00086 19.4 0.1 2.8 3 1 0 3 3 3 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AIF82523.1 - 0.002 18.0 0.0 0.0044 17.0 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Amb_V_allergen PF03913.13 AIF82523.1 - 0.016 15.2 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 Amb V Allergen Acetyltransf_6 PF13480.7 AIF82523.1 - 0.033 14.4 0.2 0.083 13.0 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 AIF82523.1 - 0.12 12.1 0.2 0.33 10.7 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain, PanZ Abhydrolase_1 PF00561.20 AIF82524.1 - 4.8e-26 92.0 0.0 3.9e-24 85.7 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIF82524.1 - 6.3e-23 82.5 0.0 7.7e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AIF82524.1 - 4.4e-17 62.1 0.0 5.9e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 AIF82524.1 - 3.1e-05 23.8 0.1 5.6e-05 22.9 0.1 1.6 2 1 0 2 2 2 1 Putative esterase Thioesterase PF00975.20 AIF82524.1 - 0.0004 20.6 0.0 0.00061 20.0 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.7 AIF82524.1 - 0.0083 15.9 0.1 0.64 9.8 0.0 3.0 1 1 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 AIF82524.1 - 0.012 15.5 0.2 0.022 14.7 0.2 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 AIF82524.1 - 0.031 14.1 0.0 5.5 6.7 0.0 2.7 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase BAAT_C PF08840.11 AIF82524.1 - 0.036 14.0 0.0 0.44 10.4 0.0 2.1 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ndr PF03096.14 AIF82524.1 - 0.053 12.2 0.0 0.14 10.8 0.0 1.6 2 0 0 2 2 2 0 Ndr family Chlorophyllase2 PF12740.7 AIF82524.1 - 0.093 11.6 0.1 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Peptidase_M1 PF01433.20 AIF82525.1 - 1.6e-54 184.8 0.7 2.6e-54 184.1 0.7 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 AIF82525.1 - 5.8e-27 95.1 0.4 2.5e-26 93.0 0.0 2.1 2 1 0 2 2 2 1 Peptidase M1 N-terminal domain HEAT_2 PF13646.6 AIF82525.1 - 4.9e-26 90.9 6.7 8.2e-10 39.0 0.0 3.5 1 1 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 AIF82525.1 - 7.4e-11 41.7 6.1 0.027 15.1 0.6 6.0 6 0 0 6 6 6 4 PBS lyase HEAT-like repeat HEAT PF02985.22 AIF82525.1 - 8.5e-06 25.6 4.4 2.8 8.4 0.0 5.1 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 AIF82525.1 - 0.17 12.4 1.5 5.7 7.6 0.1 2.9 2 1 0 2 2 2 0 HEAT-like repeat AMP-binding PF00501.28 AIF82526.1 - 3.8e-84 282.7 0.0 4.6e-84 282.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AIF82526.1 - 2e-23 83.2 2.0 3.8e-23 82.3 2.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AIF82526.1 - 4.5e-11 42.5 2.6 1.4e-10 41.0 2.6 1.9 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus HTH_20 PF12840.7 AIF82528.1 - 5.4e-14 52.0 0.1 1.1e-13 51.0 0.1 1.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_5 PF01022.20 AIF82528.1 - 6e-14 51.6 0.0 8.5e-14 51.1 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 AIF82528.1 - 4.5e-06 26.4 0.0 7.5e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 AIF82528.1 - 0.00067 19.2 0.0 0.0013 18.3 0.0 1.5 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 AIF82528.1 - 0.0036 17.2 0.0 0.006 16.5 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.6 AIF82528.1 - 0.0046 17.1 0.0 0.007 16.5 0.0 1.5 1 1 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.22 AIF82528.1 - 0.024 14.6 0.1 0.039 13.9 0.1 1.4 1 0 0 1 1 1 0 MarR family HTH_11 PF08279.12 AIF82528.1 - 0.031 14.2 0.0 0.043 13.8 0.0 1.2 1 0 0 1 1 1 0 HTH domain Rrf2 PF02082.20 AIF82528.1 - 0.039 14.3 0.0 0.053 13.9 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator HTH_45 PF14947.6 AIF82528.1 - 0.056 13.4 0.0 0.082 12.9 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix HTH_Crp_2 PF13545.6 AIF82528.1 - 0.059 13.4 0.1 0.086 12.8 0.1 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Sigma70_r4 PF04545.16 AIF82528.1 - 0.061 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 DUF2513 PF10711.9 AIF82528.1 - 0.064 13.6 0.0 0.1 12.9 0.0 1.4 1 1 0 1 1 1 0 Hypothetical protein (DUF2513) HTH_IclR PF09339.10 AIF82528.1 - 0.084 12.7 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_40 PF14493.6 AIF82528.1 - 0.1 13.1 0.0 0.12 12.8 0.0 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain AHSA1 PF08327.11 AIF82529.1 - 1.1e-80 268.0 10.9 2.7e-32 111.6 0.3 3.0 3 0 0 3 3 3 3 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 AIF82529.1 - 8.7e-18 65.0 17.1 1.8e-11 44.5 1.7 3.7 3 1 0 3 3 3 3 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIF82529.1 - 6.7e-07 29.6 8.8 0.0005 20.3 0.3 4.0 3 2 0 3 3 3 3 Polyketide cyclase / dehydrase and lipid transport Lipocalin_4 PF13648.6 AIF82529.1 - 0.066 14.2 0.4 3.1 8.8 0.0 2.6 2 0 0 2 2 2 0 Lipocalin-like domain Trm56 PF01994.16 AIF82530.1 - 2e-51 172.9 0.1 2.8e-51 172.4 0.1 1.2 1 0 0 1 1 1 1 tRNA ribose 2'-O-methyltransferase, aTrm56 Lipoprot_C PF08794.10 AIF82530.1 - 0.049 13.6 0.1 0.097 12.7 0.1 1.5 1 1 0 1 1 1 0 Lipoprotein GNA1870 C terminal like GTP-bdg_N PF13167.6 AIF82531.1 - 5.6e-21 75.0 0.3 1.8e-20 73.4 0.3 1.9 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal MMR_HSR1 PF01926.23 AIF82531.1 - 4.4e-17 62.2 0.1 2.7e-16 59.7 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP-bdg_M PF16360.5 AIF82531.1 - 6.9e-13 49.0 5.8 1.6e-12 47.8 5.8 1.7 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region FeoB_N PF02421.18 AIF82531.1 - 2.1e-08 33.8 0.0 6.6e-08 32.2 0.0 1.9 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AIF82531.1 - 3.6e-05 23.8 0.3 0.23 11.3 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 AIF82531.1 - 0.00054 19.5 0.1 0.19 11.3 0.1 3.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 AIF82531.1 - 0.001 19.0 0.1 0.0033 17.4 0.0 1.8 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 AIF82531.1 - 0.0031 17.6 0.5 0.088 12.9 0.3 2.8 1 1 1 2 2 2 1 Dynamin family SRPRB PF09439.10 AIF82531.1 - 0.0052 16.2 0.2 0.0052 16.2 0.2 2.4 2 1 1 3 3 3 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 AIF82531.1 - 0.009 16.5 0.1 0.033 14.7 0.0 2.1 1 1 1 2 2 2 1 ABC transporter TsaE PF02367.17 AIF82531.1 - 0.033 14.2 0.1 0.22 11.5 0.1 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 AIF82531.1 - 0.049 12.7 0.1 0.072 12.1 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein HTH_3 PF01381.22 AIF82532.1 - 1.5e-05 24.9 0.1 2.3e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 AIF82532.1 - 0.0021 18.4 0.0 0.0052 17.1 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain zf-dskA_traR PF01258.17 AIF82532.1 - 0.033 14.2 2.8 0.099 12.6 2.8 1.8 1 1 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger HTH_25 PF13413.6 AIF82532.1 - 0.037 13.9 0.2 0.065 13.1 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Tnp_DNA_bind PF14706.6 AIF82533.1 - 0.045 13.6 0.1 0.076 12.9 0.1 1.4 1 1 0 1 1 1 0 Transposase DNA-binding PhoU PF01895.19 AIF82534.1 - 1.2e-26 92.9 15.5 5e-18 65.3 3.9 2.7 2 0 0 2 2 2 2 PhoU domain MazE_antitoxin PF04014.18 AIF82534.1 - 1.2e-09 37.8 0.0 3.4e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin NAS PF03059.16 AIF82534.1 - 0.058 12.7 0.7 0.11 11.8 0.2 1.6 2 0 0 2 2 2 0 Nicotianamine synthase protein PUA PF01472.20 AIF82535.1 - 1.4e-10 41.0 0.5 2.1e-10 40.4 0.5 1.3 1 0 0 1 1 1 1 PUA domain TGT_C2 PF14810.6 AIF82535.1 - 3.5e-09 36.7 0.0 5.1e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Patch-forming domain C2 of tRNA-guanine transglycosylase NAC PF01849.18 AIF82536.1 - 1.3e-12 47.5 4.1 4.6e-11 42.5 1.6 2.1 1 1 1 2 2 2 2 NAC domain HOIP-UBA PF16678.5 AIF82536.1 - 0.0024 17.9 0.1 0.0033 17.5 0.1 1.2 1 0 0 1 1 1 1 HOIP UBA domain pair T2SSF PF00482.23 AIF82536.1 - 0.045 13.7 0.5 2.2 8.3 0.0 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF5471 PF17565.2 AIF82537.1 - 0.00089 19.5 2.4 0.0014 18.9 2.1 1.6 1 1 0 1 1 1 1 Family of unknown function (DUF5471) Mitofilin PF09731.9 AIF82537.1 - 0.0017 17.3 9.9 0.0019 17.1 9.9 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein V-ATPase_G_2 PF16999.5 AIF82537.1 - 0.0028 18.1 15.3 0.0046 17.3 14.0 1.9 1 1 1 2 2 2 2 Vacuolar (H+)-ATPase G subunit Activator-TraM PF11657.8 AIF82537.1 - 0.0037 17.1 6.2 0.0048 16.7 6.2 1.3 1 0 0 1 1 1 1 Transcriptional activator TraM MIF4G_like_2 PF09090.11 AIF82537.1 - 0.0064 16.0 4.0 0.0088 15.6 4.0 1.2 1 0 0 1 1 1 1 MIF4G like Apolipoprotein PF01442.18 AIF82537.1 - 0.0078 16.1 6.0 0.01 15.7 6.0 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.15 AIF82537.1 - 0.0084 15.7 3.7 0.0097 15.5 3.7 1.0 1 0 0 1 1 1 1 Exonuclease VII, large subunit Phage_Mu_Gam PF07352.12 AIF82537.1 - 0.0085 16.0 10.5 0.033 14.1 0.8 2.2 1 1 1 2 2 2 1 Bacteriophage Mu Gam like protein COG6 PF06419.11 AIF82537.1 - 0.011 14.0 6.3 0.019 13.2 0.8 2.0 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 Peptidase_M75 PF09375.10 AIF82537.1 - 0.013 15.0 1.8 0.015 14.8 1.8 1.1 1 0 0 1 1 1 0 Imelysin DUF4142 PF13628.6 AIF82537.1 - 0.015 15.6 8.2 0.025 14.8 5.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4142) Allexi_40kDa PF05549.11 AIF82537.1 - 0.033 13.7 1.8 0.04 13.4 1.8 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein 5_nucleotid PF05761.14 AIF82537.1 - 0.054 12.4 2.9 0.067 12.1 2.9 1.0 1 0 0 1 1 1 0 5' nucleotidase family ATP-synt_B PF00430.18 AIF82537.1 - 0.054 13.6 14.0 0.079 13.0 13.6 1.5 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) DUF826 PF05696.11 AIF82537.1 - 0.057 13.5 4.5 0.12 12.5 0.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF826) Fzo_mitofusin PF04799.13 AIF82537.1 - 0.11 12.0 3.6 0.54 9.8 1.2 2.0 1 1 1 2 2 2 0 fzo-like conserved region Muted PF14942.6 AIF82537.1 - 0.12 12.7 7.4 0.25 11.7 7.4 1.5 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF883 PF05957.13 AIF82537.1 - 0.12 13.0 9.5 0.37 11.4 7.1 2.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) SCAB_CC PF16712.5 AIF82537.1 - 0.16 11.8 9.8 0.28 11.0 9.6 1.6 1 1 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein Phasin PF05597.11 AIF82537.1 - 0.2 11.7 8.5 1.3 9.0 1.2 2.4 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF2344 PF10105.9 AIF82537.1 - 0.24 11.2 3.2 0.34 10.7 3.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) DUF2894 PF11445.8 AIF82537.1 - 0.26 11.7 3.3 0.33 11.4 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) TMPIT PF07851.13 AIF82537.1 - 0.33 10.2 4.9 0.41 9.8 4.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 AIF82537.1 - 0.38 10.8 6.9 0.23 11.5 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 AIF82537.1 - 0.39 11.1 7.0 0.7 10.3 1.9 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) YabA PF06156.13 AIF82537.1 - 0.54 10.9 5.9 0.47 11.1 4.6 1.6 1 1 1 2 2 2 0 Initiation control protein YabA DUF1690 PF07956.11 AIF82537.1 - 0.66 10.4 8.4 0.12 12.8 1.0 2.1 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) KfrA_N PF11740.8 AIF82537.1 - 0.71 10.6 9.1 4.9 7.9 6.3 2.2 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term XhlA PF10779.9 AIF82537.1 - 0.96 9.7 8.8 2.4e+02 2.0 8.7 3.0 1 1 0 1 1 1 0 Haemolysin XhlA DivIVA PF05103.13 AIF82537.1 - 0.99 9.5 13.1 1.4 9.0 12.6 1.5 1 1 0 1 1 1 0 DivIVA protein DUF2175 PF09943.9 AIF82537.1 - 2.5 8.5 8.8 0.46 10.8 5.0 1.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) COG2 PF06148.11 AIF82537.1 - 3.8 7.6 7.5 2.6 8.1 5.1 1.9 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF460 PF04312.13 AIF82538.1 - 0.00065 19.4 0.2 0.0015 18.2 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF460) Tex_YqgF PF16921.5 AIF82538.1 - 0.003 18.0 0.1 0.0071 16.8 0.1 1.6 1 0 0 1 1 1 1 Tex protein YqgF-like domain RuvX PF03652.15 AIF82538.1 - 0.011 16.1 0.2 0.1 13.0 0.2 2.1 1 1 0 1 1 1 0 Holliday junction resolvase DUF212 PF02681.14 AIF82538.1 - 0.094 12.8 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Divergent PAP2 family FlgD_ig PF13860.6 AIF82539.1 - 0.0055 16.5 1.1 0.0055 16.5 1.1 2.5 2 0 0 2 2 2 1 FlgD Ig-like domain DUF3244 PF11589.8 AIF82539.1 - 0.022 14.8 0.7 0.071 13.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3244) ZirS_C PF16583.5 AIF82539.1 - 0.027 14.1 2.4 0.038 13.6 0.5 2.1 2 0 0 2 2 2 0 Zinc-regulated secreted antivirulence protein C-terminal domain MG2 PF01835.19 AIF82539.1 - 0.087 13.3 0.6 0.43 11.1 0.3 2.3 2 1 1 3 3 3 0 MG2 domain CarboxypepD_reg PF13620.6 AIF82539.1 - 2.7 8.3 15.2 0.049 13.9 7.7 2.1 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain DUF4993 PF16384.5 AIF82540.1 - 0.0074 15.3 1.9 0.011 14.8 1.9 1.2 1 0 0 1 1 1 1 Domain of unknown function GRP PF07172.11 AIF82540.1 - 0.014 16.1 0.0 0.028 15.1 0.0 1.5 1 0 0 1 1 1 0 Glycine rich protein family SH3BGR PF04908.15 AIF82540.1 - 0.042 14.0 0.0 0.073 13.2 0.0 1.5 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein HTH_45 PF14947.6 AIF82541.1 - 2.1e-05 24.4 0.0 3.7e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix VraX PF17412.2 AIF82541.1 - 0.016 14.8 0.1 0.028 14.1 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function Ta0938 PF11494.8 AIF82541.1 - 0.025 14.9 0.1 0.041 14.2 0.1 1.3 1 0 0 1 1 1 0 Ta0938 HTH_24 PF13412.6 AIF82541.1 - 0.063 12.8 0.3 0.13 11.9 0.3 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TBPIP PF07106.13 AIF82541.1 - 0.073 13.0 0.3 4.5 7.3 0.0 2.4 2 0 0 2 2 2 0 TBPIP/Hop2 winged helix domain Guanylate_cyc PF00211.20 AIF82542.1 - 4.1e-05 23.3 0.0 4.8e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Sgf11 PF08209.11 AIF82543.1 - 0.0098 15.4 0.1 0.013 15.0 0.1 1.2 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) DUF2116 PF09889.9 AIF82543.1 - 0.014 15.4 0.2 0.024 14.6 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) AAA_31 PF13614.6 AIF82544.1 - 6.3e-18 65.3 0.4 5.1e-17 62.3 0.1 2.4 2 1 0 2 2 2 1 AAA domain ParA PF10609.9 AIF82544.1 - 3.6e-14 52.8 0.1 1.8e-11 44.0 0.0 3.1 3 0 0 3 3 3 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 AIF82544.1 - 5.5e-13 49.1 0.0 7.5e-13 48.7 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 AIF82544.1 - 1.2e-07 31.3 0.0 8.6e-06 25.2 0.0 2.2 2 0 0 2 2 2 1 ATPase MipZ ArsA_ATPase PF02374.15 AIF82544.1 - 7.1e-07 28.7 0.0 2e-06 27.2 0.0 1.7 2 0 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 AIF82544.1 - 6.2e-06 25.8 0.0 0.11 11.9 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 AIF82544.1 - 2.3e-05 24.0 0.0 0.00019 21.0 0.0 2.1 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ VirC1 PF07015.11 AIF82544.1 - 3.9e-05 23.1 0.1 0.00034 20.0 0.0 2.3 2 1 0 2 2 2 1 VirC1 protein CLP1_P PF16575.5 AIF82544.1 - 6.5e-05 22.8 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop SRP54 PF00448.22 AIF82544.1 - 0.00036 20.2 0.1 0.0042 16.7 0.1 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Thymidylate_kin PF02223.17 AIF82544.1 - 0.0028 17.4 0.1 0.24 11.1 0.1 2.3 2 0 0 2 2 2 1 Thymidylate kinase APS_kinase PF01583.20 AIF82544.1 - 0.011 15.6 0.0 0.031 14.1 0.0 1.7 2 0 0 2 2 1 0 Adenylylsulphate kinase AAA_28 PF13521.6 AIF82544.1 - 0.017 15.4 0.2 0.99 9.6 0.2 2.3 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 AIF82544.1 - 0.026 14.1 0.0 0.21 11.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 AIF82544.1 - 0.046 13.6 0.1 0.18 11.7 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B LytR_C PF13399.6 AIF82544.1 - 0.07 14.1 0.0 0.13 13.2 0.0 1.5 1 0 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator AAA_33 PF13671.6 AIF82544.1 - 0.074 13.2 0.0 0.095 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain PCYCGC PF13798.6 AIF82544.1 - 0.075 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function with PCYCGC motif ATP_bind_1 PF03029.17 AIF82544.1 - 0.08 12.7 0.2 0.79 9.5 0.2 2.1 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 AIF82544.1 - 0.15 11.8 0.4 0.49 10.1 0.4 1.8 1 1 0 1 1 1 0 AAA domain LpxK PF02606.14 AIF82544.1 - 0.15 11.1 0.1 0.26 10.4 0.1 1.3 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase Fic PF02661.18 AIF82545.1 - 1.1e-24 87.1 0.0 3.3e-24 85.6 0.0 1.8 2 0 0 2 2 2 1 Fic/DOC family Haem_oxygenas_2 PF14518.6 AIF82546.1 - 3.5e-06 26.9 0.0 4.5e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Iron-containing redox enzyme DUF1192 PF06698.11 AIF82547.1 - 0.06 13.4 0.4 4.1 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) PIEZO PF15917.5 AIF82547.1 - 0.41 10.1 1.9 0.82 9.1 1.9 1.4 1 0 0 1 1 1 0 Piezo DUF5392 PF17370.2 AIF82547.1 - 4.6 7.3 7.8 1.6 8.8 0.3 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5392) Coatomer_g_Cpla PF16381.5 AIF82548.1 - 0.004 17.3 0.2 0.005 17.0 0.2 1.1 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform NHase_alpha PF02979.16 AIF82548.1 - 0.031 13.6 0.1 0.035 13.4 0.1 1.2 1 0 0 1 1 1 0 Nitrile hydratase, alpha chain Methyltransf_25 PF13649.6 AIF82549.1 - 1.8e-11 44.5 0.0 2.7e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 AIF82549.1 - 2.5e-10 40.4 0.0 2.6e-09 37.1 0.0 1.9 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.12 AIF82549.1 - 1.8e-09 38.1 0.0 2.7e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF82549.1 - 3.7e-09 37.2 0.0 5.3e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF82549.1 - 6.4e-09 35.9 0.0 8.3e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF82549.1 - 1.3e-07 31.5 0.0 1.7e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 AIF82549.1 - 1.4e-05 24.6 0.0 1.8e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB UPF0146 PF03686.13 AIF82549.1 - 0.0014 18.5 0.0 0.0025 17.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0146) MTS PF05175.14 AIF82549.1 - 0.0015 18.1 0.0 0.0021 17.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 AIF82549.1 - 0.0027 17.0 0.0 0.0035 16.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 AIF82549.1 - 0.0097 15.3 0.1 0.014 14.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Pox_F11 PF04943.12 AIF82549.1 - 0.059 12.4 0.0 0.064 12.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus F11 protein NodS PF05401.11 AIF82549.1 - 0.059 13.0 0.0 0.089 12.4 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) ADH_zinc_N PF00107.26 AIF82549.1 - 0.087 12.8 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase tRNA_U5-meth_tr PF05958.11 AIF82549.1 - 0.091 11.7 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase HATPase_c PF02518.26 AIF82550.1 - 2.2e-26 92.6 0.4 8.4e-26 90.7 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 AIF82550.1 - 5.3e-16 59.2 5.4 5.3e-16 59.2 5.4 2.1 2 0 0 2 2 2 1 Cache domain HisKA PF00512.25 AIF82550.1 - 5.7e-10 39.1 0.6 2.3e-09 37.1 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain MSC PF09402.10 AIF82550.1 - 0.21 11.0 0.1 0.44 9.9 0.1 1.5 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Guanylate_cyc PF00211.20 AIF82551.1 - 4.7e-14 52.4 0.0 4.6e-13 49.2 0.0 2.0 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HTH_Tnp_ISL3 PF13542.6 AIF82551.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 PPK2 PF03976.14 AIF82552.1 - 4.8e-63 212.7 0.8 3.9e-32 111.6 1.6 2.0 2 0 0 2 2 2 2 Polyphosphate kinase 2 (PPK2) Thymidylate_kin PF02223.17 AIF82552.1 - 0.039 13.6 0.0 0.27 10.9 0.0 2.3 2 0 0 2 2 2 0 Thymidylate kinase Trehalase PF01204.18 AIF82552.1 - 0.042 12.7 0.7 0.061 12.1 0.7 1.2 1 0 0 1 1 1 0 Trehalase AAA_18 PF13238.6 AIF82552.1 - 0.11 13.0 0.8 0.5 10.9 0.7 2.2 1 1 0 1 1 1 0 AAA domain PIN PF01850.21 AIF82553.1 - 4.7e-14 52.9 0.0 5.1e-14 52.8 0.0 1.0 1 0 0 1 1 1 1 PIN domain VAPB_antitox PF02697.14 AIF82554.1 - 2.3e-18 66.7 0.1 2.7e-18 66.5 0.1 1.1 1 0 0 1 1 1 1 Putative antitoxin Amino_oxidase PF01593.24 AIF82556.1 - 2.4e-27 96.4 0.1 4.5e-27 95.4 0.1 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 AIF82556.1 - 2.7e-14 53.2 2.5 4.6e-14 52.4 0.4 2.5 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AIF82556.1 - 4.9e-12 46.1 0.4 8.3e-12 45.3 0.4 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 AIF82556.1 - 2.4e-11 43.3 0.1 4.9e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 AIF82556.1 - 9.8e-09 35.0 1.4 2e-08 34.0 0.6 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 AIF82556.1 - 2.2e-08 33.6 2.1 4.5e-08 32.6 2.1 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 AIF82556.1 - 4.3e-08 32.3 0.8 0.00034 19.4 0.9 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 AIF82556.1 - 3.1e-07 29.9 0.3 0.00012 21.5 0.3 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 AIF82556.1 - 2.8e-06 26.8 0.5 4.7e-06 26.1 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 AIF82556.1 - 9.5e-05 21.6 1.6 0.00029 20.1 0.8 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.27 AIF82556.1 - 0.0004 20.9 0.8 0.014 16.0 0.3 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 AIF82556.1 - 0.00061 18.7 0.1 0.001 18.0 0.1 1.3 1 0 0 1 1 1 1 MCRA family AlaDh_PNT_C PF01262.21 AIF82556.1 - 0.0012 18.2 1.6 0.0022 17.3 1.6 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 AIF82556.1 - 0.0023 17.9 0.4 1.9 8.5 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 AIF82556.1 - 0.0086 15.2 0.6 0.03 13.4 0.0 2.1 3 0 0 3 3 3 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 AIF82556.1 - 0.023 14.0 0.6 0.041 13.1 0.1 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 AIF82556.1 - 0.06 12.2 1.0 0.099 11.5 1.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase ThiF PF00899.21 AIF82556.1 - 0.092 12.1 0.1 0.18 11.1 0.1 1.4 1 0 0 1 1 1 0 ThiF family BSP_II PF05432.11 AIF82556.1 - 0.12 12.1 2.1 0.19 11.4 2.1 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Shikimate_DH PF01488.20 AIF82556.1 - 0.16 12.0 0.1 0.32 11.0 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TetR_N PF00440.23 AIF82557.1 - 1.3e-15 56.9 0.5 3.5e-15 55.5 0.2 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.6 AIF82557.1 - 0.00049 20.3 0.0 0.84 9.9 0.0 2.4 1 1 1 2 2 2 2 BetI-type transcriptional repressor, C-terminal TetR_C_15 PF17918.1 AIF82557.1 - 0.0006 20.5 0.0 0.0052 17.5 0.0 2.1 1 1 1 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_C_31 PF17940.1 AIF82557.1 - 0.0061 16.7 0.0 0.48 10.7 0.0 2.4 2 1 1 3 3 3 1 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 AIF82557.1 - 0.073 13.2 0.1 0.17 12.0 0.0 1.6 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase TetR_C_33 PF13305.6 AIF82557.1 - 0.092 13.5 0.1 0.39 11.5 0.0 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain zf-HC3 PF16827.5 AIF82558.1 - 0.071 13.3 1.1 0.19 11.9 0.1 2.1 2 0 0 2 2 2 0 zinc-finger CPSF73-100_C PF11718.8 AIF82558.1 - 0.078 12.5 0.5 0.1 12.1 0.5 1.1 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term PD40 PF07676.12 AIF82562.1 - 8.2e-37 124.4 16.2 8.1e-09 35.2 0.2 5.8 5 0 0 5 5 5 5 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 AIF82562.1 - 1.4e-08 33.9 5.1 0.0011 17.9 0.1 3.9 2 1 1 4 4 4 3 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF444 PF04285.12 AIF82562.1 - 0.14 11.2 0.3 0.24 10.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF444) SR-25 PF10500.9 AIF82562.1 - 4.9 6.7 8.6 8.6 5.9 8.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 AIF82562.1 - 9.2 4.2 8.6 14 3.6 8.6 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein MAGE PF01454.19 AIF82563.1 - 0.037 13.7 0.0 0.045 13.5 0.0 1.1 1 0 0 1 1 1 0 MAGE family SHE3 PF17078.5 AIF82564.1 - 1.6 8.4 14.1 0.098 12.4 6.8 2.4 3 0 0 3 3 3 0 SWI5-dependent HO expression protein 3 ZapB PF06005.12 AIF82564.1 - 3.7 8.1 30.2 0.4 11.2 3.7 4.8 5 0 0 5 5 5 0 Cell division protein ZapB DUF4157 PF13699.6 AIF82566.1 - 1.2e-33 115.2 0.6 7.2e-33 112.7 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4157) RecX PF02631.16 AIF82566.1 - 0.021 15.3 2.2 0.2 12.1 0.2 2.9 3 0 0 3 3 3 0 RecX family DUF4157 PF13699.6 AIF82567.1 - 1.1e-21 76.9 2.3 1.7e-21 76.2 0.3 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4157) DUF4156 PF13698.6 AIF82567.1 - 0.033 14.5 0.1 0.096 13.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4156) ParBc PF02195.18 AIF82568.1 - 7.3e-22 77.5 0.1 7.3e-22 77.5 0.1 1.8 2 1 0 2 2 2 1 ParB-like nuclease domain KorB PF08535.10 AIF82568.1 - 0.00038 20.4 0.1 0.0011 18.9 0.1 1.9 1 1 0 1 1 1 1 KorB domain HTH_ParB PF17762.1 AIF82568.1 - 0.0011 18.8 1.8 0.0073 16.1 0.2 3.1 3 1 0 3 3 3 1 HTH domain found in ParB protein DUF1861 PF08950.10 AIF82568.1 - 0.1 11.8 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1861) DUF4280 PF14107.6 AIF82569.1 - 0.0026 18.6 1.2 0.0046 17.7 1.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4280) GPW_gp25 PF04965.14 AIF82570.1 - 1.3e-10 40.9 0.0 1.7e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Gene 25-like lysozyme Baseplate_J PF04865.14 AIF82571.1 - 2.4e-06 26.9 0.1 1.3e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 Baseplate J-like protein AMP-binding_C PF13193.6 AIF82571.1 - 0.07 14.1 0.0 0.21 12.6 0.0 1.8 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Baseplate_J PF04865.14 AIF82572.1 - 4.4e-07 29.3 0.0 2.8e-06 26.7 0.0 2.4 2 0 0 2 2 2 1 Baseplate J-like protein DUF4245 PF14030.6 AIF82572.1 - 0.05 13.6 0.4 0.82 9.7 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4245) Sacchrp_dh_NADP PF03435.18 AIF82572.1 - 0.083 13.2 0.8 0.21 11.9 0.1 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Tail_P2_I PF09684.10 AIF82573.1 - 0.0084 16.0 0.1 0.025 14.5 0.1 1.8 1 0 0 1 1 1 1 Phage tail protein (Tail_P2_I) Cyclin_N PF00134.23 AIF82574.1 - 0.08 12.7 0.3 0.14 11.9 0.3 1.3 1 0 0 1 1 1 0 Cyclin, N-terminal domain Top6b_C PF18000.1 AIF82575.1 - 0.025 14.7 0.2 0.65 10.2 0.0 2.1 2 0 0 2 2 2 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain Phage_sheath_1 PF04984.14 AIF82576.1 - 6.7e-11 42.3 0.0 1.2e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Phage tail sheath protein subtilisin-like domain Phage_sheath_1C PF17482.2 AIF82576.1 - 2.1e-09 37.3 0.0 4.5e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Phage tail sheath C-terminal domain Phage_T4_gp19 PF06841.12 AIF82577.1 - 1.8e-41 141.1 0.0 2.1e-41 140.9 0.0 1.0 1 0 0 1 1 1 1 T4-like virus tail tube protein gp19 RE_TaqI PF09573.10 AIF82577.1 - 0.071 12.9 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 TaqI restriction endonuclease zinc_ribbon_4 PF13717.6 AIF82578.1 - 0.083 12.8 0.2 4.8 7.2 0.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Nudix_N_2 PF14803.6 AIF82578.1 - 0.19 11.7 1.0 14 5.7 0.1 2.6 2 0 0 2 2 2 0 Nudix N-terminal zf-C2HC_2 PF13913.6 AIF82578.1 - 2.4 8.2 4.4 2.1 8.4 0.4 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DUF4255 PF14065.6 AIF82580.1 - 6e-30 104.2 0.1 1.4e-29 103.0 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4255) DUF2808 PF10989.8 AIF82580.1 - 0.048 13.6 1.0 2.7 7.9 0.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2808) AAA PF00004.29 AIF82581.1 - 1.2e-24 87.2 0.0 3.7e-24 85.6 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 AIF82581.1 - 0.0049 17.0 0.0 0.014 15.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 AIF82581.1 - 0.059 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain TetR_C_32 PF09209.11 AIF82581.1 - 0.061 13.3 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain AAA_22 PF13401.6 AIF82581.1 - 0.17 12.1 0.3 1.9 8.7 0.1 2.7 2 1 0 2 2 2 0 AAA domain DUF4025 PF13217.6 AIF82584.1 - 0.015 15.2 0.5 0.028 14.2 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4025) DNA_meth_N PF18284.1 AIF82586.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 DNA methylase N-terminal domain CPT_N PF16484.5 AIF82586.1 - 0.2 11.7 0.0 0.57 10.2 0.0 1.7 1 0 0 1 1 1 0 Carnitine O-palmitoyltransferase N-terminus Thyroglobulin_1 PF00086.18 AIF82587.1 - 0.1 12.3 0.2 0.15 11.7 0.2 1.3 1 0 0 1 1 1 0 Thyroglobulin type-1 repeat HTH_20 PF12840.7 AIF82589.1 - 1.3e-05 25.2 0.7 3.1e-05 23.9 0.7 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_5 PF01022.20 AIF82589.1 - 0.0072 16.2 0.5 0.012 15.5 0.5 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_Crp_2 PF13545.6 AIF82589.1 - 0.035 14.1 0.5 0.073 13.1 0.5 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain MarR_2 PF12802.7 AIF82589.1 - 0.042 13.8 0.2 0.082 12.8 0.2 1.5 1 0 0 1 1 1 0 MarR family DUF1724 PF08350.10 AIF82589.1 - 0.13 12.4 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1724) Peptidase_S64 PF08192.11 AIF82590.1 - 0.14 10.7 9.6 0.18 10.3 9.6 1.1 1 0 0 1 1 1 0 Peptidase family S64 YtxH PF12732.7 AIF82590.1 - 3.2 8.3 6.8 3.9 8.1 0.3 2.8 2 1 1 3 3 3 0 YtxH-like protein Robl_LC7 PF03259.17 AIF82591.1 - 0.039 13.7 0.2 0.049 13.4 0.2 1.2 1 0 0 1 1 1 0 Roadblock/LC7 domain Trypsin_2 PF13365.6 AIF82596.1 - 2.1e-23 83.9 2.5 7.3e-23 82.1 2.5 1.8 1 1 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 AIF82596.1 - 3.4e-07 30.3 0.0 0.00014 21.8 0.0 2.2 2 0 0 2 2 2 2 Trypsin Peptidase_S7 PF00949.21 AIF82596.1 - 0.011 15.6 0.1 0.023 14.5 0.1 1.5 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Fis1_TPR_C PF14853.6 AIF82596.1 - 0.014 15.4 0.2 0.032 14.3 0.2 1.6 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 AIF82596.1 - 0.048 14.3 0.5 0.15 12.8 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Peptidase_S29 PF02907.15 AIF82596.1 - 0.062 13.1 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Peptidase_S46 PF10459.9 AIF82596.1 - 0.15 10.6 0.2 6.6 5.2 0.6 2.1 2 0 0 2 2 2 0 Peptidase S46 TFIIB PF00382.19 AIF82602.1 - 2.3e-29 101.2 4.4 1.5e-14 53.8 0.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIF82602.1 - 1.8e-07 30.6 0.1 3.6e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_AsnC-type PF13404.6 AIF82602.1 - 4.2e-05 23.3 0.0 0.00036 20.3 0.0 2.4 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.12 AIF82602.1 - 6.1e-05 22.9 0.0 0.00083 19.3 0.0 2.4 2 0 0 2 2 2 1 HTH domain HTH_24 PF13412.6 AIF82602.1 - 0.0003 20.3 0.1 0.0034 16.9 0.0 2.5 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Cyclin_N PF00134.23 AIF82602.1 - 0.00063 19.5 0.4 1 9.1 0.1 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain Sigma70_r4 PF04545.16 AIF82602.1 - 0.00064 19.2 0.1 0.03 13.8 0.0 2.7 3 0 0 3 3 3 1 Sigma-70, region 4 HTH_Mga PF08280.11 AIF82602.1 - 0.0028 17.7 0.0 1.8 8.6 0.0 2.7 2 0 0 2 2 2 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_Crp_2 PF13545.6 AIF82602.1 - 0.016 15.2 0.0 0.04 13.9 0.0 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Sigma70_r4_2 PF08281.12 AIF82602.1 - 0.023 14.4 0.2 0.56 9.9 0.0 2.5 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.6 AIF82602.1 - 0.026 14.3 0.0 0.079 12.8 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain HTH_3 PF01381.22 AIF82602.1 - 0.028 14.5 0.0 0.25 11.4 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix HrcA_DNA-bdg PF03444.15 AIF82602.1 - 0.053 13.2 0.1 1.2 8.9 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HTH_5 PF01022.20 AIF82602.1 - 0.068 13.1 0.0 1.1 9.2 0.1 2.5 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Rrf2 PF02082.20 AIF82602.1 - 0.081 13.3 0.1 2.5 8.5 0.0 2.5 2 0 0 2 2 2 0 Transcriptional regulator Put_DNA-bind_N PF06971.13 AIF82602.1 - 0.1 12.6 0.1 0.72 9.9 0.0 2.3 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus Zn-ribbon_8 PF09723.10 AIF82603.1 - 0.037 14.1 0.3 0.097 12.8 0.3 1.7 1 1 0 1 1 1 0 Zinc ribbon domain Bowman-Birk_leg PF00228.20 AIF82603.1 - 0.14 12.6 1.5 1.2 9.6 0.2 2.3 2 0 0 2 2 2 0 Bowman-Birk serine protease inhibitor family GTP-bdg_N PF13167.6 AIF82604.1 - 4.4e-22 78.5 0.1 1.1e-21 77.3 0.1 1.6 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal MMR_HSR1 PF01926.23 AIF82604.1 - 2.2e-17 63.2 0.3 5.4e-17 61.9 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP-bdg_M PF16360.5 AIF82604.1 - 5.3e-17 62.2 3.8 5.3e-17 62.2 3.8 2.3 2 0 0 2 2 2 1 GTP-binding GTPase Middle Region RsgA_GTPase PF03193.16 AIF82604.1 - 3e-08 33.7 0.6 0.0023 17.9 0.2 2.4 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 AIF82604.1 - 4.7e-07 29.5 0.6 1.1e-06 28.3 0.0 1.9 2 1 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.10 AIF82604.1 - 0.00026 20.5 0.1 0.00047 19.6 0.1 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 AIF82604.1 - 0.00064 20.2 0.4 0.0029 18.1 0.1 2.3 2 1 0 2 2 2 1 ABC transporter GTP_EFTU PF00009.27 AIF82604.1 - 0.0014 18.2 0.1 0.044 13.3 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.19 AIF82604.1 - 0.0015 18.2 1.8 1.4 8.5 0.4 3.0 2 1 1 3 3 3 2 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 AIF82604.1 - 0.0031 17.6 0.9 0.011 15.8 0.6 2.0 1 1 1 2 2 2 1 Dynamin family PduV-EutP PF10662.9 AIF82604.1 - 0.015 15.0 0.2 0.52 10.1 0.2 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 AIF82604.1 - 0.032 14.6 0.5 0.14 12.6 0.1 2.2 1 1 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 AIF82604.1 - 0.041 14.0 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 AIF82604.1 - 0.092 13.2 0.2 0.092 13.2 0.2 2.2 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.6 AIF82604.1 - 0.12 12.1 0.1 0.37 10.6 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1_Xtn PF16897.5 AIF82604.1 - 0.13 12.3 0.1 0.38 10.8 0.0 1.8 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Roc PF08477.13 AIF82604.1 - 0.19 12.0 0.4 1.1 9.5 0.1 2.3 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase eIF-1a PF01176.19 AIF82605.1 - 6.2e-20 70.8 1.0 7.4e-20 70.5 1.0 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myosin_N PF02736.19 AIF82605.1 - 0.00032 20.5 1.0 0.0024 17.7 0.3 2.1 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain RsgA_N PF16745.5 AIF82605.1 - 0.0026 17.5 0.5 0.0038 16.9 0.5 1.3 1 0 0 1 1 1 1 RsgA N-terminal domain Prot_ATP_ID_OB PF16450.5 AIF82605.1 - 0.024 14.6 0.1 0.036 14.0 0.1 1.1 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain Cpn60_TCP1 PF00118.24 AIF82606.1 - 9.6e-172 572.0 15.8 1.1e-171 571.8 15.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family AAA PF00004.29 AIF82607.1 - 1.3e-97 323.3 0.0 1.1e-49 168.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.18 AIF82607.1 - 1e-25 89.7 0.2 3.7e-25 87.9 0.2 2.1 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_lid_3 PF17862.1 AIF82607.1 - 1.4e-25 88.8 0.3 1.9e-13 50.0 0.1 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 AIF82607.1 - 7.2e-16 58.3 0.0 1.7e-09 37.6 0.0 3.2 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 AIF82607.1 - 4.4e-15 56.2 0.0 1.4e-06 28.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AIF82607.1 - 5.9e-14 52.8 0.2 2.1e-05 25.0 0.0 3.7 2 2 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 AIF82607.1 - 1.7e-12 47.5 0.6 1.7e-06 28.0 0.1 3.8 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AIF82607.1 - 1.4e-10 41.6 0.8 0.0054 17.0 0.0 3.9 2 2 2 4 4 4 2 AAA domain TIP49 PF06068.13 AIF82607.1 - 5.8e-10 38.9 0.1 0.00017 20.9 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_14 PF13173.6 AIF82607.1 - 1.7e-09 37.8 0.0 0.00046 20.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 AIF82607.1 - 1.5e-08 34.9 0.0 0.0036 17.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 AIF82607.1 - 5.4e-08 32.8 0.0 0.0085 15.8 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein Sigma54_activat PF00158.26 AIF82607.1 - 1.6e-07 31.2 0.1 0.049 13.3 0.1 3.7 3 1 0 3 3 3 2 Sigma-54 interaction domain CDC48_2 PF02933.17 AIF82607.1 - 1.9e-07 30.7 0.0 5e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 RNA_helicase PF00910.22 AIF82607.1 - 2e-07 31.4 0.0 0.012 16.0 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.6 AIF82607.1 - 4.1e-07 30.6 0.0 0.011 16.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 AIF82607.1 - 9.8e-07 28.7 0.0 0.033 13.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 AIF82607.1 - 2.1e-06 27.7 0.0 0.017 15.0 0.0 3.0 2 1 0 2 2 2 2 Bacterial dnaA protein AAA_28 PF13521.6 AIF82607.1 - 3.6e-06 27.3 0.0 0.068 13.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 AIF82607.1 - 4.3e-06 26.8 0.0 0.02 14.8 0.0 3.1 2 1 1 3 3 3 2 ATPase domain predominantly from Archaea ATPase PF06745.13 AIF82607.1 - 4.5e-06 26.2 1.1 0.15 11.3 0.1 3.7 3 1 0 4 4 3 2 KaiC Mg_chelatase PF01078.21 AIF82607.1 - 5.1e-06 26.0 0.3 0.037 13.4 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TsaE PF02367.17 AIF82607.1 - 6e-06 26.3 0.0 0.2 11.7 0.0 2.6 2 1 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 AIF82607.1 - 6.3e-06 25.8 0.1 0.031 13.8 0.0 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region PhoH PF02562.16 AIF82607.1 - 2e-05 24.1 0.3 0.18 11.3 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein DUF815 PF05673.13 AIF82607.1 - 2.2e-05 23.8 0.0 0.042 13.0 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) NACHT PF05729.12 AIF82607.1 - 5e-05 23.3 0.0 0.75 9.7 0.0 3.4 3 1 0 4 4 3 2 NACHT domain ABC_tran PF00005.27 AIF82607.1 - 7.9e-05 23.2 0.0 0.68 10.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_25 PF13481.6 AIF82607.1 - 9.1e-05 22.1 6.6 1.2 8.7 0.2 4.2 2 2 1 4 4 4 2 AAA domain Cytidylate_kin PF02224.18 AIF82607.1 - 0.00033 20.5 0.1 0.61 9.8 0.0 2.4 2 0 0 2 2 2 2 Cytidylate kinase Zeta_toxin PF06414.12 AIF82607.1 - 0.00034 20.0 0.0 0.18 11.0 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin Guanylate_kin PF00625.21 AIF82607.1 - 0.00056 19.6 0.1 2.8 7.6 0.0 3.8 2 1 1 3 3 3 1 Guanylate kinase AAA_3 PF07726.11 AIF82607.1 - 0.00067 19.5 0.0 0.14 12.0 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 AIF82607.1 - 0.00074 18.7 0.1 0.33 10.0 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 AIF82607.1 - 0.00079 18.7 0.0 0.51 9.5 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain AAA_30 PF13604.6 AIF82607.1 - 0.0018 18.0 0.2 1.6 8.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 AIF82607.1 - 0.0019 17.5 0.0 0.54 9.4 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 AIF82607.1 - 0.0033 17.4 2.1 6.4 6.6 0.0 4.4 3 1 1 4 4 4 0 NTPase AAA_17 PF13207.6 AIF82607.1 - 0.0068 16.8 0.0 0.94 9.9 0.0 2.9 2 0 0 2 2 2 1 AAA domain CPT PF07931.12 AIF82607.1 - 0.013 15.3 0.0 4.6 7.0 0.0 2.7 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein T2SSE PF00437.20 AIF82607.1 - 0.015 14.4 0.0 6.1 5.8 0.0 2.6 3 0 0 3 3 2 0 Type II/IV secretion system protein Sigma54_activ_2 PF14532.6 AIF82607.1 - 0.019 15.1 0.0 3.4 7.8 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain Vps4_C PF09336.10 AIF82607.1 - 0.028 14.4 0.3 14 5.8 0.0 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain PduV-EutP PF10662.9 AIF82607.1 - 0.037 13.8 0.0 8.9 6.1 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 AIF82607.1 - 0.041 14.2 1.4 4.1 7.7 0.2 3.0 2 1 0 3 3 2 0 AAA domain TniB PF05621.11 AIF82607.1 - 0.042 13.3 0.0 18 4.7 0.0 3.3 3 1 1 4 4 4 0 Bacterial TniB protein AAA_11 PF13086.6 AIF82607.1 - 0.044 13.6 0.0 0.62 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 AIF82607.1 - 0.066 13.0 0.1 17 5.3 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain IPT PF01745.16 AIF82607.1 - 0.068 12.6 0.1 8.2 5.7 0.0 2.6 2 0 0 2 2 2 0 Isopentenyl transferase ResIII PF04851.15 AIF82607.1 - 0.082 12.9 0.0 15 5.5 0.0 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit KAP_NTPase PF07693.14 AIF82607.1 - 0.12 11.6 0.5 5.8 6.1 0.0 2.7 2 2 2 4 4 3 0 KAP family P-loop domain RsgA_GTPase PF03193.16 AIF82607.1 - 0.12 12.2 0.0 9.7 6.1 0.0 2.8 3 0 0 3 3 2 0 RsgA GTPase SKI PF01202.22 AIF82607.1 - 0.13 12.4 0.1 15 5.7 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase Cytidylate_kin2 PF13189.6 AIF82607.1 - 0.13 12.4 0.0 11 6.1 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase-like family PIF1 PF05970.14 AIF82607.1 - 0.14 11.3 0.0 16 4.5 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase AAA_21 PF13304.6 AIF82607.1 - 0.15 11.9 0.4 5.9 6.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system SRPRB PF09439.10 AIF82607.1 - 0.16 11.4 0.0 17 4.8 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit GTF2I PF02946.14 AIF82608.1 - 0.085 12.9 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 GTF2I-like repeat Usp PF00582.26 AIF82609.1 - 1.3e-31 110.0 0.1 2.1e-31 109.3 0.1 1.3 1 1 0 1 1 1 1 Universal stress protein family TMF_DNA_bd PF12329.8 AIF82611.1 - 0.00097 19.1 6.3 0.0011 18.9 5.4 1.5 1 1 1 2 2 2 1 TATA element modulatory factor 1 DNA binding phiKZ_IP PF12699.7 AIF82611.1 - 0.016 14.4 0.6 0.019 14.2 0.6 1.1 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins EzrA PF06160.12 AIF82611.1 - 0.023 12.9 4.2 0.027 12.6 4.2 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA bZIP_1 PF00170.21 AIF82611.1 - 0.031 14.4 5.2 0.039 14.1 4.7 1.4 1 1 1 2 2 2 0 bZIP transcription factor DUF4795 PF16043.5 AIF82611.1 - 0.041 13.5 3.8 0.041 13.5 3.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) XhlA PF10779.9 AIF82611.1 - 0.042 14.0 2.0 0.062 13.5 2.0 1.3 1 0 0 1 1 1 0 Haemolysin XhlA DUF2802 PF10975.8 AIF82611.1 - 0.066 13.3 2.0 0.12 12.5 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) Spc24 PF08286.11 AIF82611.1 - 0.068 13.4 4.6 0.085 13.1 4.5 1.3 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 SlyX PF04102.12 AIF82611.1 - 0.075 13.7 4.0 0.15 12.7 4.0 1.6 1 1 0 1 1 1 0 SlyX Pox_A_type_inc PF04508.12 AIF82611.1 - 0.14 12.1 3.7 6.7 6.7 0.1 2.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DASH_Dad3 PF08656.10 AIF82611.1 - 0.15 12.1 3.6 0.18 11.9 3.4 1.3 1 1 0 1 1 1 0 DASH complex subunit Dad3 DUF3450 PF11932.8 AIF82611.1 - 0.16 11.2 4.6 0.19 11.0 4.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) EIF_2_alpha PF07541.12 AIF82612.1 - 2.3e-17 63.2 0.4 5.3e-17 62.0 0.1 1.8 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 AIF82612.1 - 5.7e-09 36.2 0.1 1.1e-08 35.3 0.1 1.5 1 0 0 1 1 1 1 S1 RNA binding domain EXOSC1 PF10447.9 AIF82612.1 - 0.0056 17.3 0.3 2 9.1 0.0 2.9 3 0 0 3 3 3 2 Exosome component EXOSC1/CSL4 MEDS PF14417.6 AIF82613.1 - 3.9e-15 56.1 0.0 4.7e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain ATPase PF06745.13 AIF82613.1 - 0.026 13.9 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 KaiC MEDS PF14417.6 AIF82614.1 - 1.2e-09 38.2 0.0 2.4e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain NitrOD2 PF18550.1 AIF82614.1 - 0.079 13.1 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Nitrososphaera output domain 2 NMO PF03060.15 AIF82615.1 - 8.5e-62 209.4 4.7 9.5e-59 199.4 4.7 2.3 1 1 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 AIF82615.1 - 2.3e-11 43.3 2.2 3.8e-11 42.6 2.2 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 AIF82615.1 - 1.6e-08 33.9 5.6 1.6e-06 27.4 5.6 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NanE PF04131.14 AIF82615.1 - 1.6e-06 27.4 0.1 3.6e-06 26.3 0.0 1.5 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase DHO_dh PF01180.21 AIF82615.1 - 0.0058 15.9 0.3 0.01 15.1 0.3 1.4 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase PEP_hydrolase PF09370.10 AIF82615.1 - 0.0072 15.6 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like DUF561 PF04481.12 AIF82615.1 - 0.0079 15.4 1.4 0.11 11.6 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF561) ThiG PF05690.14 AIF82615.1 - 0.01 15.1 0.8 0.016 14.5 0.8 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 AIF82615.1 - 0.011 15.2 0.8 0.019 14.5 0.8 1.4 1 1 0 1 1 1 0 Histidine biosynthesis protein Glu_synthase PF01645.17 AIF82615.1 - 0.032 13.4 2.0 0.066 12.3 2.0 1.6 1 1 0 1 1 1 0 Conserved region in glutamate synthase G3P_antiterm PF04309.12 AIF82615.1 - 0.12 11.7 0.2 0.65 9.4 0.1 2.0 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Abhydrolase_6 PF12697.7 AIF82616.1 - 1e-13 52.4 0.0 1.3e-13 52.0 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AIF82616.1 - 9e-10 38.6 0.0 4.9e-09 36.2 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AIF82616.1 - 0.0023 17.3 0.0 0.011 15.1 0.1 2.0 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 AIF82616.1 - 0.068 12.8 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Glyoxalase PF00903.25 AIF82617.1 - 1.1e-05 25.6 0.0 7.1e-05 23.0 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AIF82617.1 - 0.029 15.2 0.0 0.041 14.7 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain FAD_binding_2 PF00890.24 AIF82619.1 - 3.3e-91 306.5 1.4 4.3e-91 306.1 1.4 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 AIF82619.1 - 1.9e-21 76.4 0.7 1.9e-21 76.4 0.7 1.9 2 0 0 2 2 2 1 Fumarate reductase flavoprotein C-term HI0933_like PF03486.14 AIF82619.1 - 1.4e-07 30.6 1.0 0.00061 18.6 0.2 3.4 3 1 0 3 3 3 2 HI0933-like protein Pyr_redox_2 PF07992.14 AIF82619.1 - 3.5e-07 29.7 1.1 0.0014 18.0 0.6 3.1 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AIF82619.1 - 9.7e-06 25.2 1.8 1.9e-05 24.2 1.8 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 AIF82619.1 - 0.00044 19.4 0.2 0.001 18.2 0.2 1.6 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 AIF82619.1 - 0.002 18.6 1.3 0.13 12.9 0.2 3.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 AIF82619.1 - 0.0024 17.5 1.4 0.01 15.4 1.2 2.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 AIF82619.1 - 0.0033 16.7 0.1 0.11 11.7 0.0 2.6 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 AIF82619.1 - 0.0055 16.0 0.4 0.026 13.8 0.1 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 AIF82619.1 - 0.014 14.7 0.1 0.042 13.1 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 AIF82619.1 - 0.016 14.5 0.6 0.029 13.6 0.6 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_7 PF13241.6 AIF82619.1 - 0.12 12.8 0.0 0.37 11.2 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding Bombolitin PF08096.11 AIF82620.1 - 0.14 12.5 0.5 1.6 9.2 0.0 2.6 3 0 0 3 3 3 0 Bombolitin family YaiA PF16362.5 AIF82621.1 - 0.03 14.4 0.2 0.049 13.7 0.2 1.4 1 0 0 1 1 1 0 YaiA protein DUF3892 PF13031.6 AIF82623.1 - 4.7e-08 33.5 0.1 7.6e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3892) Intimin_C PF07979.11 AIF82623.1 - 0.00033 21.0 0.0 0.00038 20.8 0.0 1.1 1 0 0 1 1 1 1 Intimin C-type lectin domain Forkhead PF00250.18 AIF82623.1 - 0.082 13.2 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 Forkhead domain Mucin PF01456.17 AIF82624.1 - 3.1 7.8 22.2 1.7 8.6 14.8 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein AsnC_trans_reg PF01037.21 AIF82625.1 - 4.5e-12 45.8 0.0 4.8e-12 45.7 0.0 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIF82625.1 - 0.006 16.6 0.0 0.0075 16.3 0.0 1.1 1 0 0 1 1 1 1 NapD protein GSDH PF07995.11 AIF82628.1 - 7.6e-98 327.9 0.0 1e-97 327.4 0.0 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase DUF5122 PF17164.4 AIF82628.1 - 0.029 14.7 1.1 0.029 14.7 1.1 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller Reg_prop PF07494.11 AIF82628.1 - 0.05 13.8 0.0 73 4.1 0.0 3.8 3 0 0 3 3 3 0 Two component regulator propeller Orai-1 PF07856.12 AIF82628.1 - 0.077 12.7 0.1 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 Mediator of CRAC channel activity PMSR PF01625.21 AIF82629.1 - 1.7e-65 219.9 0.8 2e-65 219.7 0.8 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase SelR PF01641.18 AIF82630.1 - 4.6e-40 136.5 0.0 5.5e-40 136.2 0.0 1.0 1 0 0 1 1 1 1 SelR domain zf-CCHC_2 PF13696.6 AIF82630.1 - 0.0054 16.5 0.8 0.013 15.3 0.8 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-RRN7 PF11781.8 AIF82630.1 - 0.015 15.0 3.1 0.13 12.0 0.8 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf_UBZ PF18439.1 AIF82630.1 - 0.023 14.3 1.2 0.85 9.3 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger RIG-I_C-RD PF11648.8 AIF82630.1 - 0.031 14.5 0.1 3 8.1 0.0 2.1 2 0 0 2 2 2 0 C-terminal domain of RIG-I Ribosomal_L37e PF01907.19 AIF82630.1 - 0.057 13.6 4.1 0.11 12.7 0.5 2.2 2 0 0 2 2 2 0 Ribosomal protein L37e zf-HIT PF04438.16 AIF82630.1 - 0.067 13.1 2.0 0.47 10.4 0.5 2.2 2 0 0 2 2 2 0 HIT zinc finger Yippee-Mis18 PF03226.14 AIF82630.1 - 0.068 13.4 0.0 2.6 8.3 0.0 2.1 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DZR PF12773.7 AIF82630.1 - 0.12 12.4 2.3 0.69 10.0 1.7 2.1 1 1 2 3 3 3 0 Double zinc ribbon zf-Mss51 PF13824.6 AIF82630.1 - 0.16 12.1 0.9 13 6.0 0.1 2.7 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 FMN_red PF03358.15 AIF82631.1 - 2.7e-15 56.5 0.0 4.1e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Rieske PF00355.26 AIF82631.1 - 2.6e-14 52.9 0.0 5.3e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIF82631.1 - 1.6e-07 31.2 0.0 4.4e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Flavodoxin_2 PF02525.17 AIF82631.1 - 0.0063 16.2 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin-like fold CBS PF00571.28 AIF82633.1 - 1.3e-27 96.0 4.2 1e-17 64.3 0.5 3.1 3 0 0 3 3 3 3 CBS domain zinc_ribbon_4 PF13717.6 AIF82640.1 - 0.21 11.5 7.1 3.5 7.6 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-RanBP PF00641.18 AIF82640.1 - 0.22 10.9 9.7 0.23 10.8 0.3 2.4 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others ADK_lid PF05191.14 AIF82640.1 - 0.27 11.2 3.6 1.9 8.6 0.4 2.1 2 0 0 2 2 2 0 Adenylate kinase, active site lid zf-C2H2_jaz PF12171.8 AIF82641.1 - 0.052 13.8 2.2 0.15 12.4 2.2 1.9 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-FCS PF06467.14 AIF82641.1 - 0.14 12.1 0.2 0.32 10.9 0.1 1.7 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Band_7 PF01145.25 AIF82642.1 - 5.3e-22 78.7 13.4 2e-21 76.8 13.4 1.8 1 1 0 1 1 1 1 SPFH domain / Band 7 family DUF202 PF02656.15 AIF82642.1 - 0.034 14.6 1.1 0.15 12.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF202) tRNA_NucTran2_2 PF13735.6 AIF82642.1 - 0.056 13.4 1.2 0.11 12.5 1.2 1.4 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative Vpu PF00558.19 AIF82642.1 - 0.37 10.6 0.0 0.37 10.6 0.0 2.4 2 0 0 2 2 2 0 Vpu protein EphA2_TM PF14575.6 AIF82642.1 - 2.6 9.0 6.3 6.3 7.8 0.0 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain LpxB PF02684.15 AIF82643.1 - 0.031 13.1 0.2 0.033 13.0 0.2 1.1 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase DUF573 PF04504.14 AIF82643.1 - 0.069 13.8 2.1 0.097 13.3 2.1 1.3 1 1 0 1 1 1 0 Protein of unknown function, DUF573 DUF1003 PF06210.11 AIF82643.1 - 1.7 8.8 4.0 0.83 9.8 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1003) CTP_transf_1 PF01148.20 AIF82645.1 - 0.075 12.8 11.5 0.05 13.4 9.7 1.6 1 1 1 2 2 2 0 Cytidylyltransferase family Herpes_LMP1 PF05297.11 AIF82645.1 - 1.2 8.3 6.2 0.21 10.7 2.6 1.5 1 1 1 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Collagen PF01391.18 AIF82647.1 - 0.0037 17.0 4.7 0.0037 17.0 4.7 2.2 2 0 0 2 2 2 2 Collagen triple helix repeat (20 copies) Glyco_hydro_67N PF03648.14 AIF82648.1 - 0.37 11.1 1.6 0.54 10.6 0.4 1.7 1 1 1 2 2 2 0 Glycosyl hydrolase family 67 N-terminus VCBS PF13517.6 AIF82649.1 - 1.1e-16 61.1 11.1 9.3e-08 32.6 5.2 3.5 3 0 0 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF3269 PF11673.8 AIF82649.1 - 0.0043 17.4 0.7 14 6.1 0.0 4.4 5 0 0 5 5 5 1 Protein of unknown function (DUF3269) IL33 PF15095.6 AIF82649.1 - 0.013 15.0 0.4 5.9 6.3 0.0 2.8 2 1 1 3 3 3 0 Interleukin 33 SnoaL PF07366.12 AIF82649.1 - 0.028 14.2 0.5 6.5 6.6 0.1 2.4 1 1 1 2 2 2 0 SnoaL-like polyketide cyclase TolB_N PF04052.13 AIF82649.1 - 0.04 14.1 1.3 22 5.3 0.0 4.2 4 1 1 5 5 5 0 TolB amino-terminal domain TM231 PF10149.9 AIF82649.1 - 0.7 9.2 5.5 62 2.8 0.1 3.8 2 1 1 4 4 4 0 Transmembrane protein 231 CAP PF00188.26 AIF82650.1 - 1e-05 26.4 0.1 2.6e-05 25.1 0.1 1.7 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF4611 PF15387.6 AIF82650.1 - 0.069 13.4 0.1 0.069 13.4 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 AIF82650.1 - 0.18 11.5 3.8 8.4 6.0 1.0 2.4 2 0 0 2 2 2 0 FAM176 family Sigma70_ner PF04546.13 AIF82650.1 - 0.2 11.5 6.9 0.49 10.2 0.1 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region CHDNT PF08073.12 AIF82651.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 CHDNT (NUC034) domain Lon_C PF05362.13 AIF82652.1 - 2.5e-13 50.1 2.2 5e-13 49.1 2.2 1.4 1 1 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain BNR_2 PF13088.6 AIF82652.1 - 0.024 13.9 1.0 1.2 8.4 0.1 3.0 3 1 0 3 3 3 0 BNR repeat-like domain ChlI PF13541.6 AIF82652.1 - 0.08 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Subunit ChlI of Mg-chelatase BNR PF02012.20 AIF82652.1 - 0.33 11.1 7.4 34 5.0 0.2 4.4 3 0 0 3 3 3 0 BNR/Asp-box repeat Glyoxalase PF00903.25 AIF82653.1 - 3e-06 27.4 2.6 2e-05 24.8 2.6 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Corona_S1 PF01600.16 AIF82654.1 - 0.17 10.6 0.0 0.18 10.5 0.0 1.0 1 0 0 1 1 1 0 Coronavirus S1 glycoprotein PTAC PF06130.12 AIF82655.1 - 0.086 13.0 0.0 0.19 11.9 0.0 1.6 1 1 0 1 1 1 0 Phosphate propanoyltransferase PGA2 PF07543.12 AIF82657.1 - 0.038 14.0 0.2 0.045 13.7 0.2 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 Ytp1 PF10355.9 AIF82657.1 - 0.074 12.2 8.2 0.089 12.0 6.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (Ytp1) DUF5516 PF17637.2 AIF82657.1 - 0.13 12.0 3.3 0.4 10.5 3.3 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5516) FixQ PF05545.11 AIF82657.1 - 0.31 11.0 0.2 0.31 11.0 0.2 2.8 3 1 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ Oleosin PF01277.17 AIF82657.1 - 3.3 7.5 22.2 2 8.2 20.4 1.6 1 1 1 2 2 2 0 Oleosin Big_7 PF17957.1 AIF82658.1 - 5.6e-13 49.4 8.0 6.8e-13 49.2 7.3 1.5 1 1 0 1 1 1 1 Bacterial Ig domain DUF4625 PF15418.6 AIF82658.1 - 5.5e-05 23.4 0.3 0.025 14.8 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4625) Gmad2 PF10648.9 AIF82658.1 - 0.00017 21.7 0.8 0.00026 21.2 0.2 1.7 2 0 0 2 2 2 1 Immunoglobulin-like domain of bacterial spore germination Glyco_hydro_66 PF13199.6 AIF82658.1 - 0.028 13.1 0.2 0.037 12.7 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 Phage_TAC_7 PF10109.9 AIF82658.1 - 0.13 12.4 0.0 0.52 10.5 0.0 2.0 2 0 0 2 2 2 0 Phage tail assembly chaperone proteins, E, or 41 or 14 Presenilin PF01080.17 AIF82659.1 - 7 5.3 9.2 7.1 5.3 9.2 1.0 1 0 0 1 1 1 0 Presenilin Hexapep PF00132.24 AIF82660.1 - 2e-11 43.2 11.9 0.00067 19.3 0.1 4.5 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 AIF82660.1 - 0.00095 18.9 7.8 0.011 15.4 2.0 3.9 3 1 1 4 4 4 1 Hexapeptide repeat of succinyl-transferase Pkinase PF00069.25 AIF82661.1 - 1.5e-46 158.9 0.0 1.9e-46 158.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AIF82661.1 - 5.1e-30 104.6 0.0 6.1e-30 104.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AIF82661.1 - 1.7e-07 31.4 0.0 0.00073 19.5 0.0 2.3 1 1 0 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 AIF82661.1 - 0.017 14.7 0.1 5.9 6.5 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Cas_Csy3 PF09615.10 AIF82663.1 - 0.17 11.2 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy3) Serinc PF03348.15 AIF82664.1 - 0.1 11.5 1.3 0.19 10.6 1.3 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) HTH_ABP1_N PF18107.1 AIF82664.1 - 1.6 8.5 10.0 0.61 9.8 1.6 3.4 3 0 0 3 3 3 0 Fission yeast centromere protein N-terminal domain F420H2_quin_red PF04075.14 AIF82666.1 - 4.6e-13 49.4 0.2 5.3e-13 49.2 0.2 1.0 1 0 0 1 1 1 1 F420H(2)-dependent quinone reductase DUF2255 PF10012.9 AIF82666.1 - 3e-07 30.6 0.8 3.7e-07 30.3 0.8 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2255) Putative_PNPOx PF01243.20 AIF82666.1 - 0.043 14.0 0.0 0.078 13.2 0.0 1.5 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase SafA PF17073.5 AIF82667.1 - 0.095 12.7 0.7 0.2 11.6 0.0 1.8 1 1 1 2 2 2 0 Two-component-system connector protein Cupredoxin_1 PF13473.6 AIF82668.1 - 5.4e-05 23.3 0.0 0.00014 21.9 0.0 1.8 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 AIF82668.1 - 0.00088 19.7 0.0 0.0038 17.6 0.0 2.1 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family LUD_dom PF02589.15 AIF82668.1 - 0.021 14.5 0.1 0.042 13.6 0.1 1.5 1 0 0 1 1 1 0 LUD domain CHB_HEX_C_1 PF13290.6 AIF82670.1 - 3.9e-23 81.2 8.3 1.2e-22 79.7 8.3 1.9 1 0 0 1 1 1 1 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 AIF82670.1 - 2.5e-16 59.6 5.2 5.5e-16 58.5 5.2 1.6 1 0 0 1 1 1 1 Fn3 associated Polysacc_deac_1 PF01522.21 AIF82670.1 - 1.6e-10 40.9 0.0 3e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Prok-E2_C PF14459.6 AIF82670.1 - 0.028 14.6 0.1 0.12 12.5 0.0 2.0 2 0 0 2 2 2 0 Prokaryotic E2 family C DUF1120 PF06551.12 AIF82670.1 - 0.078 13.2 0.8 6.9 6.9 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1120) Glyoxalase PF00903.25 AIF82673.1 - 8.5e-21 74.5 0.3 4.7e-09 36.5 0.0 2.5 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 AIF82673.1 - 8.3e-11 42.1 0.1 2.2e-05 24.7 0.0 2.9 2 1 1 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AIF82673.1 - 3e-05 24.8 0.0 0.32 11.8 0.0 2.6 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_2 PF12681.7 AIF82673.1 - 0.00054 19.9 0.1 0.83 9.6 0.0 3.1 3 0 0 3 3 3 2 Glyoxalase-like domain CppA_C PF14507.6 AIF82673.1 - 0.011 16.5 0.0 3.5 8.4 0.0 2.4 2 1 0 2 2 2 0 CppA C-terminal Glyoxalase_3 PF13468.6 AIF82673.1 - 0.064 13.4 1.8 0.31 11.2 0.7 2.5 3 1 0 3 3 3 0 Glyoxalase-like domain CopG_antitoxin PF12441.8 AIF82675.1 - 0.0009 19.7 0.2 0.015 15.8 0.0 2.5 2 1 1 3 3 3 1 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIF82675.1 - 0.054 13.3 0.0 0.09 12.6 0.0 1.3 1 0 0 1 1 1 0 HicB family ABM PF03992.16 AIF82676.1 - 4.6e-07 29.8 0.1 6.2e-07 29.4 0.1 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase SOR PF07682.11 AIF82676.1 - 0.00024 20.1 0.0 0.00026 20.0 0.0 1.1 1 0 0 1 1 1 1 Sulphur oxygenase reductase TauD PF02668.16 AIF82676.1 - 0.029 14.2 0.0 0.035 13.9 0.0 1.0 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family Cu-oxidase_3 PF07732.15 AIF82677.1 - 2.7e-28 98.3 5.5 5.1e-23 81.3 0.1 2.8 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 AIF82677.1 - 2.2e-19 69.5 13.8 1e-10 41.5 0.0 4.4 4 1 0 4 4 4 3 Multicopper oxidase Copper-bind PF00127.20 AIF82677.1 - 1.1e-11 45.0 3.6 4e-07 30.4 0.1 3.8 2 2 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF82677.1 - 1.9e-11 44.0 0.0 4e-07 30.1 0.0 3.8 3 2 0 3 3 3 3 Cupredoxin-like domain CBM53 PF16760.5 AIF82677.1 - 0.13 12.9 0.0 0.13 12.9 0.0 2.8 3 0 0 3 3 3 0 Starch/carbohydrate-binding module (family 53) Hemerythrin PF01814.23 AIF82678.1 - 1.9e-10 41.4 8.8 1.1e-09 39.0 3.6 1.8 1 1 1 2 2 2 2 Hemerythrin HHE cation binding domain DUF1296 PF06972.11 AIF82678.1 - 0.089 12.9 0.1 8 6.7 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1296) AAA_5 PF07728.14 AIF82679.1 - 7.6e-28 97.2 0.0 1.1e-27 96.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 AIF82679.1 - 3.3e-12 46.4 0.0 4.7e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 AIF82679.1 - 2.9e-07 31.0 0.0 5.3e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 AIF82679.1 - 8e-07 28.7 0.0 1.4e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 AIF82679.1 - 1.5e-06 28.7 0.2 4.1e-06 27.3 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 AIF82679.1 - 2.2e-05 24.5 0.0 4.1e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 AIF82679.1 - 6.9e-05 22.9 0.0 0.0001 22.3 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 AIF82679.1 - 7.3e-05 22.6 0.3 0.00027 20.7 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AIF82679.1 - 0.00017 21.9 0.1 0.00035 20.9 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_6 PF12774.7 AIF82679.1 - 0.00022 20.3 0.0 0.00099 18.2 0.0 1.9 1 1 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA_11 PF13086.6 AIF82679.1 - 0.00031 20.6 0.0 0.00047 20.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain MCM PF00493.23 AIF82679.1 - 0.00035 19.7 0.0 0.00077 18.6 0.0 1.5 1 1 0 1 1 1 1 MCM P-loop domain NACHT PF05729.12 AIF82679.1 - 0.001 19.0 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Sigma54_activat PF00158.26 AIF82679.1 - 0.0011 18.7 0.1 0.0034 17.1 0.1 1.8 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 AIF82679.1 - 0.0012 18.2 0.1 0.53 9.6 0.0 2.2 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI KAP_NTPase PF07693.14 AIF82679.1 - 0.0015 17.9 0.0 0.0021 17.4 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain RuvB_N PF05496.12 AIF82679.1 - 0.0018 18.0 0.1 0.0089 15.8 0.1 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain SRP54 PF00448.22 AIF82679.1 - 0.0029 17.3 0.0 0.0057 16.3 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_28 PF13521.6 AIF82679.1 - 0.0036 17.6 0.1 0.01 16.1 0.0 1.8 2 0 0 2 2 1 1 AAA domain TsaE PF02367.17 AIF82679.1 - 0.004 17.1 0.0 0.0085 16.1 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 AIF82679.1 - 0.005 17.0 0.0 0.011 15.8 0.0 1.6 1 1 0 1 1 1 1 Sigma-54 interaction domain RNA_helicase PF00910.22 AIF82679.1 - 0.006 17.0 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Roc PF08477.13 AIF82679.1 - 0.0082 16.4 0.1 0.025 14.8 0.1 1.7 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 AIF82679.1 - 0.0085 16.6 0.1 0.025 15.1 0.1 1.7 2 1 0 2 2 1 1 ABC transporter AAA_33 PF13671.6 AIF82679.1 - 0.0091 16.2 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AIF82679.1 - 0.0091 16.5 0.0 0.019 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 AIF82679.1 - 0.011 15.5 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_35 PF14516.6 AIF82679.1 - 0.013 14.3 0.0 0.04 12.8 0.0 1.7 1 1 0 2 2 2 0 AAA-like domain AAA_24 PF13479.6 AIF82679.1 - 0.013 15.2 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 AIF82679.1 - 0.015 15.2 0.1 0.026 14.5 0.1 1.4 1 0 0 1 1 1 0 NTPase TniB PF05621.11 AIF82679.1 - 0.017 14.6 0.0 0.036 13.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein ATPase PF06745.13 AIF82679.1 - 0.026 13.8 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 AIF82679.1 - 0.027 14.4 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase T2SSE PF00437.20 AIF82679.1 - 0.032 13.3 0.0 0.06 12.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 AIF82679.1 - 0.035 13.8 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ATP_bind_1 PF03029.17 AIF82679.1 - 0.051 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 AIF82679.1 - 0.051 13.1 0.4 0.14 11.7 0.1 1.8 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 AIF82679.1 - 0.058 13.3 0.0 0.08 12.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_19 PF13245.6 AIF82679.1 - 0.058 13.7 0.5 0.22 11.9 0.1 2.0 2 1 1 3 3 2 0 AAA domain MobB PF03205.14 AIF82679.1 - 0.059 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B CbbQ_C PF08406.10 AIF82679.1 - 0.068 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 CbbQ/NirQ/NorQ C-terminal DnaB_C PF03796.15 AIF82679.1 - 0.079 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain MMR_HSR1 PF01926.23 AIF82679.1 - 0.1 12.7 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF815 PF05673.13 AIF82679.1 - 0.11 11.6 0.0 0.25 10.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_23 PF13476.6 AIF82679.1 - 0.11 13.0 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 AIF82679.1 - 0.11 11.6 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain VWA PF00092.28 AIF82680.1 - 5e-05 23.6 0.1 0.00082 19.7 0.1 2.4 1 1 0 1 1 1 1 von Willebrand factor type A domain TAL_FSA PF00923.19 AIF82681.1 - 3.1e-59 200.7 0.3 5.9e-58 196.5 0.3 2.1 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Transket_pyr PF02779.24 AIF82682.1 - 1.1e-33 116.4 0.0 1.6e-33 115.9 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 AIF82682.1 - 1.5e-31 108.9 0.2 2.8e-31 108.0 0.2 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain Ribul_P_3_epim PF00834.19 AIF82683.1 - 3.1e-58 196.4 0.1 4.6e-58 195.9 0.1 1.2 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family Transketolase_N PF00456.21 AIF82683.1 - 2.3e-50 171.5 0.0 4.1e-50 170.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain DXP_synthase_N PF13292.6 AIF82683.1 - 6.7e-08 32.1 0.1 0.00012 21.4 0.1 2.9 2 1 0 3 3 3 2 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 AIF82683.1 - 7.6e-08 31.7 0.1 1.8e-07 30.4 0.0 1.6 1 1 1 2 2 2 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 AIF82683.1 - 0.00017 21.4 0.2 0.0023 17.7 0.2 2.4 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Radical_SAM PF04055.21 AIF82683.1 - 0.024 15.0 0.2 6.1 7.2 0.1 3.4 3 1 0 3 3 3 0 Radical SAM superfamily FYRN PF05964.14 AIF82684.1 - 0.0021 17.9 0.0 0.0041 16.9 0.0 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus Peptidase_M17 PF00883.21 AIF82685.1 - 2.1e-121 405.0 0.0 2.6e-121 404.7 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 AIF82685.1 - 5.2e-21 74.8 0.1 1.6e-20 73.2 0.0 1.9 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain DUF1294 PF06961.13 AIF82685.1 - 0.01 16.1 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1294) Med25_VWA PF11265.8 AIF82685.1 - 0.017 15.0 0.0 0.045 13.6 0.0 1.6 2 0 0 2 2 2 0 Mediator complex subunit 25 von Willebrand factor type A ABC_tran PF00005.27 AIF82687.1 - 4.2e-38 130.9 0.0 5.7e-18 65.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 AIF82687.1 - 5.6e-11 42.3 1.8 0.00049 19.6 0.0 3.1 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain RLI PF04068.15 AIF82687.1 - 9.9e-10 38.1 1.3 2.4e-09 36.9 1.3 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 AIF82687.1 - 4.2e-08 33.4 5.2 0.14 11.9 0.0 4.2 2 2 2 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.27 AIF82687.1 - 9.5e-08 31.6 3.3 9.5e-08 31.6 3.3 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_6 PF12837.7 AIF82687.1 - 6.8e-06 25.9 12.6 9e-05 22.4 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 AIF82687.1 - 0.00014 21.9 10.3 0.00023 21.2 10.3 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 AIF82687.1 - 0.00055 20.5 8.7 0.0011 19.5 8.7 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain MMR_HSR1 PF01926.23 AIF82687.1 - 0.00075 19.6 1.2 0.095 12.8 0.4 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.6 AIF82687.1 - 0.00089 19.1 0.0 0.29 10.8 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 AIF82687.1 - 0.0009 19.2 0.7 0.015 15.2 0.1 2.5 3 0 0 3 3 2 1 RsgA GTPase SbcCD_C PF13558.6 AIF82687.1 - 0.001 19.3 0.1 2.5 8.4 0.1 2.7 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit Fer4_10 PF13237.6 AIF82687.1 - 0.0013 18.8 1.3 0.0013 18.8 1.3 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIF82687.1 - 0.0018 18.3 0.7 0.0018 18.3 0.7 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_29 PF13555.6 AIF82687.1 - 0.0055 16.4 0.2 0.13 12.0 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain Fer4_16 PF13484.6 AIF82687.1 - 0.0093 16.9 6.6 0.01 16.8 0.2 2.4 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 AIF82687.1 - 0.013 15.6 10.5 0.027 14.6 10.5 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain NB-ARC PF00931.22 AIF82687.1 - 0.016 14.4 0.2 0.37 9.9 0.0 2.8 3 0 0 3 3 3 0 NB-ARC domain AAA_23 PF13476.6 AIF82687.1 - 0.018 15.6 0.1 0.78 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 AIF82687.1 - 0.05 14.0 1.8 5.7 7.3 0.1 2.7 2 2 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 AIF82687.1 - 0.066 13.4 0.7 6.1 7.0 0.0 3.0 4 0 0 4 4 2 0 AAA domain AAA_28 PF13521.6 AIF82687.1 - 0.097 12.9 1.0 48 4.1 0.0 3.5 4 0 0 4 4 3 0 AAA domain KAP_NTPase PF07693.14 AIF82687.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain FeoB_N PF02421.18 AIF82687.1 - 0.15 11.6 0.9 3.2 7.3 0.3 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B Septin PF00735.18 AIF82687.1 - 0.16 11.2 0.1 14 4.9 0.0 2.2 2 0 0 2 2 2 0 Septin Fer4_4 PF12800.7 AIF82687.1 - 2.3 8.9 12.4 0.58 10.8 2.7 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_3 PF12798.7 AIF82687.1 - 4.3 8.5 14.7 0.6 11.2 3.0 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 AIF82687.1 - 6.2 7.5 8.9 0.38 11.3 1.5 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIF82687.1 - 6.6 7.3 8.2 1.1 9.8 1.5 1.9 1 1 1 2 2 2 0 4Fe-4S dicluster domain Met_10 PF02475.16 AIF82688.1 - 8e-59 198.7 1.3 1.1e-58 198.3 1.3 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.10 AIF82688.1 - 1e-07 31.7 0.0 1.8e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 AIF82688.1 - 0.0023 17.4 0.2 0.0023 17.4 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 AIF82688.1 - 0.0053 16.3 0.0 0.0098 15.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain TRM PF02005.16 AIF82688.1 - 0.0063 15.7 0.3 0.0074 15.5 0.3 1.4 1 1 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_25 PF13649.6 AIF82688.1 - 0.034 14.8 0.0 0.073 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltrans_SAM PF10672.9 AIF82688.1 - 0.095 11.8 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase Phage_holin_1 PF04531.13 AIF82689.1 - 0.033 14.7 0.7 0.041 14.4 0.7 1.1 1 0 0 1 1 1 0 Bacteriophage holin Phage_holin_3_6 PF07332.11 AIF82689.1 - 0.039 14.0 7.3 0.044 13.8 7.3 1.0 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4131 PF13567.6 AIF82689.1 - 0.14 11.8 0.4 0.16 11.6 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2157 PF09925.9 AIF82689.1 - 0.22 11.3 5.6 0.26 11.0 5.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Dodecin PF07311.12 AIF82690.1 - 2.8e-22 78.7 3.4 3.1e-22 78.6 3.4 1.0 1 0 0 1 1 1 1 Dodecin 4HB_MCP_1 PF12729.7 AIF82691.1 - 7.9e-08 32.0 3.7 2.1e-06 27.4 0.7 2.3 2 0 0 2 2 2 2 Four helix bundle sensory module for signal transduction DUF835 PF05763.12 AIF82691.1 - 1e-05 25.2 0.0 2.6e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF835) Acetyltransf_1 PF00583.25 AIF82692.1 - 3.9e-19 69.0 0.1 5e-19 68.7 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AIF82692.1 - 8.5e-12 45.3 0.2 1.3e-11 44.7 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AIF82692.1 - 8.6e-11 41.9 0.3 1.3e-10 41.3 0.3 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AIF82692.1 - 7.8e-09 35.4 0.2 1.6e-08 34.4 0.1 1.5 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 AIF82692.1 - 1.3e-05 25.2 0.0 2.9e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 AIF82692.1 - 0.0012 18.5 0.0 0.0031 17.2 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Peptidase_M50 PF02163.22 AIF82693.1 - 2.1e-13 50.1 10.8 6.5e-08 32.1 0.3 2.5 1 1 1 2 2 2 2 Peptidase family M50 Peptidase_M48 PF01435.18 AIF82693.1 - 0.18 11.6 0.1 0.38 10.5 0.1 1.5 1 0 0 1 1 1 0 Peptidase family M48 Pribosyltran PF00156.27 AIF82695.1 - 4.6e-16 58.7 0.5 7.3e-16 58.1 0.5 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AIF82695.1 - 0.00053 19.5 0.2 0.00072 19.1 0.2 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 AIF82695.1 - 0.0065 16.0 0.1 0.011 15.3 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase LemA PF04011.12 AIF82696.1 - 1.1e-45 155.1 1.8 1.6e-45 154.6 1.8 1.3 1 0 0 1 1 1 1 LemA family RNase_Zc3h12a PF11977.8 AIF82696.1 - 0.017 14.9 0.4 0.023 14.5 0.4 1.2 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain Blo-t-5 PF11642.8 AIF82696.1 - 0.08 12.9 0.1 0.24 11.4 0.1 1.7 1 1 1 2 2 2 0 Mite allergen Blo t 5 RabGAP-TBC PF00566.18 AIF82696.1 - 0.091 12.4 0.6 0.16 11.6 0.5 1.4 1 1 0 1 1 1 0 Rab-GTPase-TBC domain DUF4487 PF14868.6 AIF82696.1 - 0.14 11.0 0.3 0.17 10.6 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) TPM_phosphatase PF04536.14 AIF82697.1 - 7.2e-17 61.7 0.0 1.7e-16 60.5 0.0 1.6 1 1 0 1 1 1 1 TPM domain RCR PF12273.8 AIF82697.1 - 0.027 15.1 0.5 4.6 7.9 0.2 2.4 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red TBP PF00352.21 AIF82698.1 - 9.2e-54 179.4 0.1 9.1e-27 92.8 0.1 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 AIF82698.1 - 5.9e-07 29.5 0.0 0.014 15.5 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) UPF0047 PF01894.17 AIF82699.1 - 3.7e-36 123.8 0.0 4.4e-36 123.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 Peptidase_S24 PF00717.23 AIF82700.1 - 1.8e-08 34.2 1.4 4.7e-08 32.9 1.4 1.9 1 1 0 1 1 1 1 Peptidase S24-like TrbC PF04956.13 AIF82700.1 - 0.1 12.8 2.6 1.8 8.8 0.1 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family BAH PF01426.18 AIF82700.1 - 0.21 11.4 0.0 0.36 10.7 0.0 1.4 1 0 0 1 1 1 0 BAH domain FeoB_associated PF12669.7 AIF82700.1 - 4.9 7.6 5.2 5.5 7.5 0.2 2.3 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein TPR_2 PF07719.17 AIF82702.1 - 4.5e-34 113.8 0.0 4.6e-06 26.3 0.1 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 AIF82702.1 - 4.5e-32 108.5 0.3 6.1e-06 25.8 0.0 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_14 PF13428.6 AIF82702.1 - 6.4e-20 70.1 0.3 0.0014 19.3 0.0 6.2 2 1 5 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 AIF82702.1 - 1.8e-19 70.0 1.6 0.00012 22.5 0.1 4.8 3 1 2 5 5 5 5 Tetratricopeptide repeat TPR_16 PF13432.6 AIF82702.1 - 1.8e-19 70.1 0.0 2.7e-07 31.1 0.0 3.9 2 1 2 4 4 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 AIF82702.1 - 2.3e-19 67.9 0.1 0.0008 19.4 0.0 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 AIF82702.1 - 2.5e-18 66.1 0.7 0.00022 21.5 0.1 6.2 2 1 4 6 6 6 5 Tetratricopeptide repeat ANAPC3 PF12895.7 AIF82702.1 - 1e-15 57.7 0.0 7.3e-08 32.5 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 AIF82702.1 - 1.8e-14 53.7 0.0 5.3e-06 26.5 0.1 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 AIF82702.1 - 1.8e-13 49.9 2.6 0.00013 21.6 0.1 5.6 4 3 3 7 7 7 3 TPR repeat TPR_7 PF13176.6 AIF82702.1 - 2.3e-11 42.9 1.5 0.14 12.2 0.0 6.4 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 AIF82702.1 - 2.9e-11 43.2 0.3 0.18 12.5 0.1 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_10 PF13374.6 AIF82702.1 - 1.1e-09 37.9 0.2 3.7 7.6 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat NARP1 PF12569.8 AIF82702.1 - 4.7e-09 35.7 0.4 0.078 11.9 0.1 3.2 1 1 2 3 3 3 3 NMDA receptor-regulated protein 1 TPR_17 PF13431.6 AIF82702.1 - 5.4e-08 32.7 4.1 3.3 8.3 0.0 7.2 8 0 0 8 8 7 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AIF82702.1 - 3.4e-07 30.2 1.0 9.6 6.4 0.0 5.9 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 AIF82702.1 - 4.5e-06 26.1 0.7 0.16 11.1 0.0 3.4 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 AIF82702.1 - 1.6e-05 25.1 2.5 1.9 8.8 0.0 4.8 3 3 3 6 6 6 1 Tetratricopeptide repeat TPR_4 PF07721.14 AIF82702.1 - 0.00017 21.9 0.2 0.61 10.9 0.0 4.3 5 0 0 5 5 4 1 Tetratricopeptide repeat BTAD PF03704.17 AIF82702.1 - 0.00037 20.9 0.0 3.5 8.0 0.0 3.4 2 1 1 3 3 3 1 Bacterial transcriptional activator domain DUF3856 PF12968.7 AIF82702.1 - 0.00043 20.4 0.2 0.65 10.1 0.0 4.3 2 1 2 4 4 4 1 Domain of Unknown Function (DUF3856) PPR PF01535.20 AIF82702.1 - 0.00066 19.8 0.1 24 5.5 0.0 4.3 4 0 0 4 4 4 0 PPR repeat ChAPs PF09295.10 AIF82702.1 - 0.00086 18.4 0.0 0.0026 16.8 0.0 1.6 1 1 1 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) HrpB1_HrpK PF09613.10 AIF82702.1 - 0.001 18.7 0.0 0.15 11.7 0.0 2.9 2 1 1 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) PknG_TPR PF16918.5 AIF82702.1 - 0.0013 17.6 0.0 0.0017 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase G tetratricopeptide repeat SRP_TPR_like PF17004.5 AIF82702.1 - 0.0018 18.3 0.2 12 5.9 0.0 4.2 2 1 1 3 3 3 0 Putative TPR-like repeat TOM20_plant PF06552.12 AIF82702.1 - 0.003 17.3 0.1 1.1 8.9 0.0 3.4 2 1 1 3 3 3 1 Plant specific mitochondrial import receptor subunit TOM20 SPOB_a PF14689.6 AIF82702.1 - 0.017 14.8 0.1 9.8 6.0 0.0 4.2 4 0 0 4 4 4 0 Sensor_kinase_SpoOB-type, alpha-helical domain Wzy_C_2 PF11846.8 AIF82702.1 - 0.05 13.5 0.0 16 5.4 0.0 3.1 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal RNA_pol_Rpb1_1 PF04997.12 AIF82702.1 - 0.089 12.1 0.9 0.19 11.0 0.0 1.8 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 1 MIT PF04212.18 AIF82702.1 - 0.096 12.8 3.7 1.5 9.0 0.3 4.1 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain DUF4363 PF14276.6 AIF82702.1 - 0.14 12.3 7.7 0.34 11.0 4.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) OrfB_IS605 PF01385.19 AIF82703.1 - 7.1e-19 68.2 1.2 7.1e-19 68.2 1.2 2.1 2 1 1 3 3 2 1 Probable transposase OrfB_Zn_ribbon PF07282.11 AIF82703.1 - 9.4e-17 60.7 0.6 2e-16 59.7 0.6 1.6 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 AIF82703.1 - 0.0014 17.9 1.2 0.23 10.9 0.1 2.5 2 0 0 2 2 2 1 zinc-ribbon domain DUF1451 PF07295.11 AIF82703.1 - 0.0071 16.4 0.6 0.019 15.0 0.6 1.7 1 0 0 1 1 1 1 Zinc-ribbon containing domain HypA PF01155.19 AIF82703.1 - 0.0084 16.1 0.2 0.021 14.8 0.1 1.7 2 0 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 AIF82703.1 - 0.0093 16.0 0.2 0.021 14.8 0.2 1.6 1 0 0 1 1 1 1 Double zinc ribbon CpXC PF14353.6 AIF82703.1 - 0.036 14.1 0.2 0.64 10.1 0.1 2.7 1 1 0 2 2 2 0 CpXC protein zinc_ribbon_2 PF13240.6 AIF82703.1 - 0.05 13.3 1.4 4.2 7.2 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Vta1_C PF18097.1 AIF82703.1 - 0.076 12.7 0.1 0.19 11.4 0.1 1.7 1 0 0 1 1 1 0 Vta1 C-terminal domain Zn-ribbon_8 PF09723.10 AIF82703.1 - 0.095 12.8 1.1 0.25 11.5 1.1 1.8 1 1 0 1 1 1 0 Zinc ribbon domain zf_UBZ PF18439.1 AIF82703.1 - 0.12 12.0 2.2 1 9.0 0.1 2.5 1 1 1 2 2 2 0 Ubiquitin-Binding Zinc Finger zf_C2H2_10 PF18414.1 AIF82703.1 - 0.14 11.7 0.9 0.31 10.6 0.1 1.9 2 0 0 2 2 2 0 C2H2 type zinc-finger Zn_ribbon_SprT PF17283.2 AIF82703.1 - 0.37 10.8 7.6 0.25 11.3 2.3 2.7 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-ACC PF17848.1 AIF82703.1 - 0.84 9.8 3.9 14 5.8 0.1 3.0 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain zf-NADH-PPase PF09297.11 AIF82703.1 - 0.96 9.2 4.0 3.2 7.5 4.0 1.9 1 1 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain Rpr2 PF04032.16 AIF82703.1 - 1.4 9.3 10.4 17 5.8 2.1 3.6 2 1 1 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF4379 PF14311.6 AIF82703.1 - 7.4 7.0 7.8 1.5 9.3 1.6 2.5 2 0 0 2 2 2 0 Probable Zinc-ribbon domain Nop PF01798.18 AIF82704.1 - 6.9e-64 215.5 0.3 1e-63 214.9 0.3 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Fibrillarin PF01269.17 AIF82705.1 - 3e-86 288.2 0.0 3.5e-86 288.0 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin Methyltransf_25 PF13649.6 AIF82705.1 - 0.00011 22.8 0.0 0.00038 21.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 AIF82705.1 - 0.00021 21.1 0.1 0.00029 20.6 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GCD14 PF08704.10 AIF82705.1 - 0.0057 16.4 0.0 0.0084 15.8 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 AIF82705.1 - 0.0057 16.3 0.0 0.015 15.0 0.0 1.6 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 AIF82705.1 - 0.045 13.9 0.0 0.06 13.5 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 AIF82705.1 - 0.21 11.4 0.0 0.34 10.7 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain RNase_HII PF01351.18 AIF82706.1 - 6.6e-46 156.6 0.5 7.9e-46 156.4 0.5 1.0 1 0 0 1 1 1 1 Ribonuclease HII PALP PF00291.25 AIF82707.1 - 1.4e-21 77.2 0.2 8.7e-20 71.3 0.1 3.2 2 1 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme TRM PF02005.16 AIF82708.1 - 1.1e-93 314.4 0.0 1.3e-93 314.2 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 AIF82708.1 - 0.00028 20.7 0.0 0.00065 19.5 0.0 1.7 2 0 0 2 2 2 1 Met-10+ like-protein MTS PF05175.14 AIF82708.1 - 0.0056 16.2 0.1 0.017 14.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 AIF82708.1 - 0.0058 16.1 0.0 0.0094 15.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TackOD1 PF18551.1 AIF82708.1 - 0.0082 15.8 0.3 0.015 15.0 0.3 1.4 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 Methyltransf_3 PF01596.17 AIF82708.1 - 0.0089 15.2 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_31 PF13847.6 AIF82708.1 - 0.036 13.9 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF4023 PF13215.6 AIF82708.1 - 0.25 11.4 1.7 0.63 10.1 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) NAD_binding_1 PF00175.21 AIF82710.1 - 7.7e-12 45.8 0.0 1.2e-11 45.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AIF82710.1 - 5.8e-11 42.6 0.0 9.6e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AIF82710.1 - 0.14 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Ferric reductase NAD binding domain DUF424 PF04242.13 AIF82711.1 - 7.7e-15 54.9 0.1 8.5e-15 54.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF424) DUF1874 PF08960.10 AIF82711.1 - 0.037 14.2 0.0 0.051 13.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1874) RIO1 PF01163.22 AIF82712.1 - 2.7e-54 183.6 0.7 5.3e-54 182.7 0.0 1.7 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.25 AIF82712.1 - 3e-05 23.5 0.0 6.5e-05 22.4 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 AIF82712.1 - 0.00021 21.3 3.5 0.16 11.8 0.0 3.3 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 AIF82712.1 - 0.00025 20.5 0.0 0.0042 16.5 0.0 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 AIF82712.1 - 0.0024 16.7 0.6 0.0034 16.2 0.6 1.5 1 1 0 1 1 1 1 Fungal protein kinase Spectrin_like PF18373.1 AIF82712.1 - 0.016 15.2 0.0 0.79 9.8 0.0 3.0 3 0 0 3 3 3 0 Spectrin like domain Kinase-like PF14531.6 AIF82712.1 - 0.08 12.2 0.1 0.44 9.8 0.0 2.0 2 0 0 2 2 2 0 Kinase-like KH_1 PF00013.29 AIF82713.1 - 4.8e-13 48.7 5.4 1e-06 28.4 1.7 2.4 2 0 0 2 2 2 2 KH domain KH_2 PF07650.17 AIF82713.1 - 0.0012 18.7 3.4 0.64 9.9 0.1 2.4 2 0 0 2 2 2 2 KH domain KH_8 PF17903.1 AIF82713.1 - 0.027 14.6 0.0 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Krr1 KH1 domain KH_4 PF13083.6 AIF82713.1 - 0.25 11.2 1.7 5.2 7.0 0.1 2.6 2 0 0 2 2 2 0 KH domain ArsA_HSP20 PF17886.1 AIF82714.1 - 0.0019 17.7 0.0 0.0042 16.6 0.0 1.6 1 1 0 1 1 1 1 HSP20-like domain found in ArsA RseC_MucC PF04246.12 AIF82714.1 - 0.023 14.6 0.2 0.036 14.0 0.2 1.3 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Flavoprotein PF02441.19 AIF82715.1 - 2.7e-27 95.5 0.0 3.8e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 Flavoprotein CofC PF01983.16 AIF82715.1 - 0.068 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Guanylyl transferase CofC like PfkB PF00294.24 AIF82716.1 - 1.2e-25 90.4 0.0 2e-25 89.7 0.0 1.3 1 1 0 1 1 1 1 pfkB family carbohydrate kinase ABM PF03992.16 AIF82717.1 - 1.4e-08 34.7 0.0 1.7e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Ferritin PF00210.24 AIF82718.1 - 1.2e-26 93.3 0.2 1.4e-26 93.1 0.2 1.0 1 0 0 1 1 1 1 Ferritin-like domain Ferritin_2 PF13668.6 AIF82718.1 - 0.0021 18.3 0.1 0.0027 17.9 0.1 1.3 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 AIF82718.1 - 0.007 16.8 0.1 0.017 15.5 0.1 1.7 1 1 0 1 1 1 1 Rubrerythrin DUF455 PF04305.14 AIF82718.1 - 0.05 13.2 0.1 0.16 11.5 0.0 1.6 1 1 0 2 2 2 0 Protein of unknown function (DUF455) TrmB PF01978.19 AIF82719.1 - 1.2e-08 34.8 0.0 1.5e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB PNP_UDP_1 PF01048.20 AIF82722.1 - 3.2e-45 154.2 0.0 3.6e-45 154.0 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Pribosyltran PF00156.27 AIF82723.1 - 2e-12 46.9 0.1 2.6e-12 46.6 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AIF82723.1 - 7.9e-05 22.2 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Peptidase_M10 PF00413.24 AIF82724.1 - 0.072 12.9 0.4 0.11 12.3 0.4 1.5 1 1 0 1 1 1 0 Matrixin HpaB_N PF11794.8 AIF82725.1 - 7e-95 317.8 0.0 1.4e-94 316.8 0.0 1.5 2 0 0 2 2 2 1 4-hydroxyphenylacetate 3-hydroxylase N terminal HpaB PF03241.13 AIF82725.1 - 6.4e-75 250.7 0.3 8.8e-75 250.2 0.3 1.2 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase C terminal DUF4829 PF16111.5 AIF82725.1 - 0.082 13.7 0.8 0.57 11.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4829) zf-Tim10_DDP PF02953.15 AIF82725.1 - 0.12 12.1 0.1 0.27 10.9 0.1 1.6 1 0 0 1 1 1 0 Tim10/DDP family zinc finger Acyl-CoA_dh_M PF02770.19 AIF82725.1 - 0.13 12.4 0.0 0.39 10.9 0.0 1.7 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain Glyoxalase_6 PF18029.1 AIF82726.1 - 1.8e-06 28.7 0.0 3.2e-06 27.9 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 AIF82726.1 - 5.5e-06 26.6 0.0 3.6e-05 24.0 0.0 1.9 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily RNA_pol_Rpc34 PF05158.12 AIF82727.1 - 7.1e-05 22.3 0.4 0.00069 19.1 0.1 2.1 1 1 1 2 2 2 1 RNA polymerase Rpc34 subunit MarR PF01047.22 AIF82727.1 - 0.016 15.1 0.1 0.034 14.1 0.1 1.5 1 0 0 1 1 1 0 MarR family B-block_TFIIIC PF04182.12 AIF82727.1 - 0.059 13.5 0.1 0.078 13.2 0.1 1.5 1 1 0 1 1 1 0 B-block binding subunit of TFIIIC FtsJ PF01728.19 AIF82728.1 - 6.5e-57 192.5 0.0 7.4e-57 192.3 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 AIF82728.1 - 1.6e-06 28.0 0.1 2.8e-05 24.0 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF82728.1 - 0.00014 21.7 0.0 0.00066 19.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF82728.1 - 0.00028 21.5 0.2 0.0024 18.5 0.1 2.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF82728.1 - 0.1 13.2 0.1 0.4 11.4 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain DUF373 PF04123.13 AIF82729.1 - 2.1e-93 313.4 9.1 2.7e-93 313.1 9.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF373) DUF4064 PF13273.6 AIF82729.1 - 3.6 7.9 16.6 0.18 12.1 8.6 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) HKR_ArcB_TM PF18415.1 AIF82729.1 - 8 7.3 7.6 0.73 10.7 2.2 2.1 2 0 0 2 2 2 0 Histidine kinase receptor ArcB trans-membrane domain DUF4227 PF14004.6 AIF82730.1 - 0.062 13.3 0.1 0.075 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) O-ag_pol_Wzy PF14296.6 AIF82731.1 - 0.027 13.1 7.0 0.028 13.1 7.0 1.1 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy Oxidored_q2 PF00420.24 AIF82731.1 - 0.09 12.4 6.9 0.15 11.7 6.9 1.5 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF2207 PF09972.9 AIF82731.1 - 0.32 9.7 2.0 0.38 9.5 2.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF983 PF06170.12 AIF82731.1 - 4.4 7.8 6.6 3.7 8.0 1.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF983) NUDIX PF00293.28 AIF82732.1 - 3.2e-17 62.8 0.1 3.7e-17 62.6 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain OMPdecase PF00215.24 AIF82733.1 - 1.2e-28 100.3 0.5 1.5e-28 99.9 0.5 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Adenylsucc_synt PF00709.21 AIF82736.1 - 3.1e-82 276.8 0.4 4.3e-39 134.6 0.0 3.0 1 1 2 3 3 3 3 Adenylosuccinate synthetase Iron_traffic PF04362.14 AIF82738.1 - 6.6e-07 28.9 0.0 8.6e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial Fe(2+) trafficking zf_C2H2_13 PF18508.1 AIF82738.1 - 0.0093 15.5 0.8 0.99 9.0 0.5 2.2 2 0 0 2 2 2 2 Zinc finger domain DZR PF12773.7 AIF82739.1 - 0.0077 16.2 1.2 0.011 15.7 1.2 1.2 1 0 0 1 1 1 1 Double zinc ribbon Laminin_EGF PF00053.24 AIF82739.1 - 0.03 14.5 1.1 0.042 14.0 1.1 1.2 1 0 0 1 1 1 0 Laminin EGF domain DUF3042 PF11240.8 AIF82739.1 - 0.044 13.8 0.8 0.084 12.9 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) HypA PF01155.19 AIF82739.1 - 0.068 13.2 0.0 0.081 12.9 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rubredoxin_2 PF18073.1 AIF82739.1 - 0.14 11.9 1.9 11 5.8 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain Zn-ribbon_8 PF09723.10 AIF82739.1 - 0.25 11.5 2.3 1.1 9.4 2.3 1.9 1 1 0 1 1 1 0 Zinc ribbon domain IBR PF01485.21 AIF82740.1 - 0.00026 21.1 0.7 0.00038 20.6 0.7 1.3 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain zinc_ribbon_4 PF13717.6 AIF82740.1 - 0.0017 18.3 3.3 0.018 14.9 3.3 2.0 1 1 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_6 PF14599.6 AIF82740.1 - 0.0025 17.8 1.2 0.0036 17.3 1.2 1.2 1 0 0 1 1 1 1 Zinc-ribbon zf-ACC PF17848.1 AIF82740.1 - 0.022 14.8 0.4 4.7 7.4 0.0 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Ribosomal_S27e PF01667.17 AIF82740.1 - 0.023 14.4 3.8 0.12 12.0 3.9 1.9 1 1 0 1 1 1 0 Ribosomal protein S27 zinc_ribbon_5 PF13719.6 AIF82740.1 - 0.034 13.9 3.1 0.076 12.8 3.1 1.5 1 1 0 1 1 1 0 zinc-ribbon domain HypA PF01155.19 AIF82740.1 - 0.064 13.3 0.3 0.07 13.1 0.3 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Raf1_N PF18578.1 AIF82740.1 - 0.08 13.4 0.1 0.08 13.4 0.1 1.0 1 0 0 1 1 1 0 Rubisco accumulation factor 1 alpha helical domain zf-ribbon_3 PF13248.6 AIF82740.1 - 0.1 12.0 2.3 0.89 9.1 2.3 2.0 1 1 0 1 1 1 0 zinc-ribbon domain Glutaredoxin PF00462.24 AIF82740.1 - 0.11 12.7 1.4 0.14 12.4 1.4 1.4 1 1 0 1 1 1 0 Glutaredoxin PhnA_Zn_Ribbon PF08274.12 AIF82740.1 - 0.43 10.6 5.4 0.36 10.8 2.1 2.0 1 1 1 2 2 2 0 PhnA Zinc-Ribbon CybS PF05328.12 AIF82741.1 - 0.036 13.8 0.2 0.083 12.6 0.2 1.8 1 1 0 1 1 1 0 CybS, succinate dehydrogenase cytochrome B small subunit HTH_45 PF14947.6 AIF82742.1 - 1.8e-10 40.6 0.0 9.8e-10 38.3 0.0 1.8 1 1 0 1 1 1 1 Winged helix-turn-helix Mrr_N PF14338.6 AIF82742.1 - 0.011 15.9 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 Mrr N-terminal domain HTH_27 PF13463.6 AIF82742.1 - 0.042 14.3 0.0 0.06 13.8 0.0 1.4 1 1 0 1 1 1 0 Winged helix DNA-binding domain PMT_2 PF13231.6 AIF82743.1 - 7.6e-06 26.2 18.5 7.6e-06 26.2 18.5 3.8 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Phage_holin_2_4 PF16082.5 AIF82743.1 - 0.1 12.4 1.1 0.18 11.5 0.3 1.8 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Big_7 PF17957.1 AIF82744.1 - 0.03 15.1 0.3 0.18 12.6 0.3 2.3 1 1 0 1 1 1 0 Bacterial Ig domain Glycos_transf_2 PF00535.26 AIF82745.1 - 2.8e-29 102.1 0.0 4.4e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 GtrA PF04138.14 AIF82745.1 - 2.4e-22 79.4 10.7 3.6e-21 75.6 11.4 2.1 1 1 0 1 1 1 1 GtrA-like protein Glyco_tranf_2_3 PF13641.6 AIF82745.1 - 1.9e-10 41.0 0.0 2.8e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 AIF82745.1 - 0.0055 16.2 0.0 0.0096 15.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 AIF82745.1 - 0.035 13.6 0.0 0.083 12.4 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase like family 2 DUF5519 PF17648.1 AIF82746.1 - 1.3e-31 108.9 0.0 1.4e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5519) Phage_lysozyme2 PF18013.1 AIF82746.1 - 0.073 13.1 0.0 0.078 13.0 0.0 1.1 1 0 0 1 1 1 0 Phage tail lysozyme NOA36 PF06524.12 AIF82747.1 - 0.32 10.3 3.3 0.25 10.6 3.3 1.1 1 0 0 1 1 1 0 NOA36 protein ADH_N PF08240.12 AIF82748.1 - 2.4e-31 107.8 1.8 4e-31 107.1 0.6 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIF82748.1 - 4.3e-07 30.0 0.0 1.6e-06 28.1 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 AIF82748.1 - 3.7e-05 23.5 0.4 3.7e-05 23.5 0.4 2.5 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-associated AlaDh_PNT_C PF01262.21 AIF82748.1 - 0.0036 16.6 0.0 0.0056 16.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 AIF82748.1 - 0.015 14.0 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein DUF892 PF05974.12 AIF82749.1 - 2.2e-17 63.5 4.8 3.2e-17 63.0 4.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF892) DUF1068 PF06364.12 AIF82749.1 - 0.041 13.8 0.8 0.084 12.7 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) DUF2383 PF09537.10 AIF82749.1 - 0.13 12.6 1.7 0.35 11.2 1.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF2383) TM_helix PF05552.12 AIF82750.1 - 2.4e-17 62.6 16.1 3.4e-11 42.9 1.6 3.4 3 0 0 3 3 3 2 Conserved TM helix MS_channel PF00924.18 AIF82750.1 - 3.7e-12 46.2 2.3 3.7e-12 46.2 2.3 1.7 2 0 0 2 2 2 1 Mechanosensitive ion channel DUF543 PF04418.12 AIF82750.1 - 4.1 7.5 5.7 4.1 7.5 1.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF543) DUF2382 PF09557.10 AIF82751.1 - 2.8e-25 88.7 27.4 4.8e-25 88.0 27.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2382) MIP PF00230.20 AIF82752.1 - 9.5e-48 162.9 19.2 1.1e-47 162.7 19.2 1.0 1 0 0 1 1 1 1 Major intrinsic protein Tymo_coat PF00983.18 AIF82752.1 - 0.024 14.5 0.1 0.037 13.8 0.1 1.3 1 0 0 1 1 1 0 Tymovirus coat protein 2TM PF13239.6 AIF82752.1 - 1 9.7 4.0 26 5.2 0.0 2.6 2 1 0 2 2 2 0 2TM domain DUF2171 PF09939.9 AIF82753.1 - 2.9e-07 30.7 0.2 1.2e-05 25.5 0.1 2.3 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2171) PRC PF05239.16 AIF82753.1 - 0.021 14.9 0.6 11 6.2 0.2 2.8 2 1 0 2 2 2 0 PRC-barrel domain BAT PF15915.5 AIF82755.1 - 0.077 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 GAF and HTH_10 associated domain NHL PF01436.21 AIF82756.1 - 8.1e-09 35.1 9.9 0.2 11.8 0.0 6.2 7 0 0 7 7 7 3 NHL repeat Cytochrom_D1 PF02239.16 AIF82756.1 - 1.1e-07 30.8 1.2 0.0028 16.3 0.1 3.2 2 1 1 3 3 3 3 Cytochrome D1 heme domain FlaG PF03646.15 AIF82756.1 - 7.7 6.7 5.9 47 4.2 0.0 3.9 4 0 0 4 4 4 0 FlaG protein DUF2946 PF11162.8 AIF82757.1 - 0.054 14.2 8.8 0.076 13.7 8.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) CbtA PF09490.10 AIF82757.1 - 0.25 11.1 4.4 0.31 10.8 4.4 1.1 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) DUF2796 PF10986.8 AIF82757.1 - 3.1 7.7 27.1 3.4 7.6 27.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) THAP PF05485.12 AIF82759.1 - 0.017 16.0 2.7 0.45 11.5 2.7 2.0 1 1 0 1 1 1 0 THAP domain YqaJ PF09588.10 AIF82759.1 - 0.034 14.3 0.2 0.037 14.2 0.2 1.1 1 0 0 1 1 1 0 YqaJ-like viral recombinase domain tRNA-Thr_ED PF08915.11 AIF82760.1 - 1.4e-43 148.2 0.4 2.9e-43 147.2 0.4 1.5 1 0 0 1 1 1 1 Archaea-specific editing domain of threonyl-tRNA synthetase HGTP_anticodon PF03129.20 AIF82760.1 - 1.5e-24 86.0 2.4 3.9e-24 84.6 2.4 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AIF82760.1 - 2.8e-18 66.5 0.1 5.5e-18 65.6 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 AIF82760.1 - 0.001 18.7 0.7 0.0019 17.8 0.7 1.3 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs UPF0270 PF06794.12 AIF82760.1 - 0.27 11.3 2.2 2 8.5 0.0 3.3 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0270) Arginase PF00491.21 AIF82761.1 - 3.2e-56 190.9 0.0 3.9e-56 190.6 0.0 1.0 1 0 0 1 1 1 1 Arginase family DNA_pol_B PF00136.21 AIF82762.1 - 2e-46 158.7 0.1 1.3e-45 156.0 0.1 2.1 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 AIF82762.1 - 5.5e-33 114.5 0.3 1.1e-32 113.6 0.3 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_exo2 PF10108.9 AIF82762.1 - 0.00027 20.7 0.0 0.00072 19.3 0.0 1.7 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 AIF82762.1 - 0.0017 18.3 0.0 0.0073 16.3 0.0 2.1 2 0 0 2 2 2 1 RNase_H superfamily DNA_pol_B_2 PF03175.13 AIF82762.1 - 0.017 14.0 0.0 0.21 10.4 0.0 2.4 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral DAO PF01266.24 AIF82763.1 - 1.2e-46 160.0 0.0 1.5e-46 159.6 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Mqo PF06039.15 AIF82763.1 - 5.1e-12 45.1 0.0 1e-09 37.5 0.0 2.2 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) Pyr_redox_2 PF07992.14 AIF82763.1 - 8.7e-05 21.9 0.0 0.2 10.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AIF82763.1 - 0.0087 16.3 0.0 0.027 14.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 AIF82763.1 - 0.056 14.0 0.0 1.9 9.1 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 AIF82763.1 - 0.062 13.3 0.2 2.7 8.0 0.1 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 AIF82763.1 - 0.09 11.5 0.1 0.27 9.9 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein Trp_halogenase PF04820.14 AIF82763.1 - 0.1 11.4 0.4 9.4 4.9 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase FAD_binding_3 PF01494.19 AIF82763.1 - 0.11 11.7 0.3 11 5.2 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 AIF82763.1 - 0.11 11.5 0.1 1.9 7.4 0.0 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein PIN PF01850.21 AIF82764.1 - 5e-07 30.3 0.2 7.2e-07 29.7 0.2 1.3 1 0 0 1 1 1 1 PIN domain DUF2827 PF10933.8 AIF82764.1 - 0.026 13.2 0.1 0.032 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2827) CcdA PF07362.12 AIF82765.1 - 1.9e-05 25.0 1.2 2.2e-05 24.8 1.2 1.2 1 0 0 1 1 1 1 Post-segregation antitoxin CcdA Ribosomal_L5 PF00281.19 AIF82765.1 - 0.021 15.1 0.8 0.041 14.2 0.8 1.6 1 1 0 1 1 1 0 Ribosomal protein L5 DUF2115 PF09888.9 AIF82765.1 - 0.026 15.0 1.1 0.027 15.0 1.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) ThiP_synth PF10120.9 AIF82765.1 - 0.029 14.0 0.3 0.035 13.7 0.3 1.1 1 0 0 1 1 1 0 Thiamine-phosphate synthase DUF1195 PF06708.11 AIF82765.1 - 0.034 13.9 0.3 0.034 13.9 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) PhetRS_B1 PF18262.1 AIF82765.1 - 0.051 13.8 0.3 0.06 13.6 0.3 1.3 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain MT0933_antitox PF14013.6 AIF82765.1 - 0.064 13.6 4.5 0.22 11.8 4.5 1.9 1 1 0 1 1 1 0 MT0933-like antitoxin protein Histone_HNS PF00816.21 AIF82765.1 - 0.1 13.4 6.8 3.9 8.4 5.7 2.1 1 1 1 2 2 2 0 H-NS histone family Con-6 PF10346.9 AIF82765.1 - 0.3 11.1 0.7 0.3 11.1 0.7 2.6 2 1 1 3 3 3 0 Conidiation protein 6 GreA_GreB_N PF03449.15 AIF82765.1 - 1.6 8.9 10.5 0.47 10.6 5.6 2.4 1 1 2 3 3 3 0 Transcription elongation factor, N-terminal NurA PF09376.10 AIF82767.1 - 3.3e-12 46.6 0.1 1e-11 45.0 0.1 1.7 1 1 0 1 1 1 1 NurA domain gerPA PF10676.9 AIF82767.1 - 0.014 15.6 0.0 0.03 14.6 0.0 1.5 1 0 0 1 1 1 0 Spore germination protein gerPA/gerPF DUF87 PF01935.17 AIF82768.1 - 1.6e-36 126.5 0.2 3e-36 125.6 0.2 1.5 1 0 0 1 1 1 1 Helicase HerA, central domain DUF853 PF05872.12 AIF82768.1 - 0.0003 19.5 0.1 0.052 12.1 0.0 2.1 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF853) HAS-barrel PF09378.10 AIF82768.1 - 0.0038 17.4 0.1 0.012 15.7 0.1 1.9 1 0 0 1 1 1 1 HAS barrel domain AAA_10 PF12846.7 AIF82768.1 - 0.0042 16.1 0.4 2.7 6.8 0.0 2.9 2 1 0 2 2 2 2 AAA-like domain ABC_tran PF00005.27 AIF82768.1 - 0.0099 16.4 0.0 0.031 14.8 0.0 1.8 2 0 0 2 2 2 1 ABC transporter FtsK_SpoIIIE PF01580.18 AIF82768.1 - 0.039 13.3 1.6 0.68 9.2 0.3 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_16 PF13191.6 AIF82768.1 - 0.056 13.8 0.0 0.2 12.0 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 AIF82768.1 - 0.067 12.1 0.2 0.22 10.4 0.0 1.8 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MDM31_MDM32 PF08118.11 AIF82768.1 - 0.082 11.6 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF2283 PF10049.9 AIF82770.1 - 8.3e-07 29.1 0.0 1.5e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2283) UDP-g_GGTase PF06427.11 AIF82770.1 - 0.085 13.0 0.0 0.26 11.4 0.0 1.7 2 0 0 2 2 2 0 UDP-glucose:Glycoprotein Glucosyltransferase Metallophos_2 PF12850.7 AIF82771.1 - 3.6e-13 50.1 0.0 6.6e-13 49.2 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 AIF82771.1 - 2.1e-09 38.2 0.3 4.6e-09 37.1 0.3 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase SMC_N PF02463.19 AIF82772.1 - 2.1e-25 89.4 2.8 2e-24 86.2 2.8 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AIF82772.1 - 1.3e-17 64.9 24.2 9.2e-13 49.1 24.2 3.9 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 AIF82772.1 - 6.7e-17 62.3 1.6 4.1e-08 33.3 0.1 3.0 2 1 1 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 AIF82772.1 - 3.4e-14 53.4 0.1 9.5e-07 28.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AIF82772.1 - 3.2e-08 33.2 0.0 6.6e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 AIF82772.1 - 8.9e-08 32.3 0.0 3.1e-07 30.5 0.0 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 AIF82772.1 - 1.4e-05 25.7 6.0 0.025 15.1 0.2 3.5 3 3 0 3 3 3 2 ABC transporter AAA_27 PF13514.6 AIF82772.1 - 2.9e-05 23.8 0.2 2.9e-05 23.8 0.2 2.6 3 1 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 AIF82772.1 - 0.012 15.5 0.5 0.041 13.8 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase MukB PF04310.12 AIF82772.1 - 0.059 13.2 0.1 0.059 13.2 0.1 2.7 3 0 0 3 3 3 0 MukB N-terminal DNA_ligase_ZBD PF03119.16 AIF82772.1 - 0.11 12.5 0.1 0.37 10.8 0.1 1.9 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Thy1 PF02511.15 AIF82772.1 - 0.12 12.2 1.5 0.44 10.3 1.5 2.1 1 1 0 1 1 1 0 Thymidylate synthase complementing protein HMMR_N PF15905.5 AIF82772.1 - 0.23 10.9 25.8 0.07 12.6 11.8 3.1 3 0 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal AAA_16 PF13191.6 AIF82772.1 - 0.34 11.3 0.0 0.34 11.3 0.0 2.9 2 1 0 2 2 1 0 AAA ATPase domain Sec34 PF04136.15 AIF82772.1 - 0.43 10.5 7.3 15 5.5 0.4 3.5 3 1 0 3 3 3 0 Sec34-like family DUF1178 PF06676.11 AIF82772.1 - 2.5 8.5 12.2 5 7.5 1.3 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1178) NPV_P10 PF05531.12 AIF82772.1 - 4.6 7.8 6.5 6.8 7.2 0.2 3.7 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Syntaxin-6_N PF09177.11 AIF82772.1 - 6.6 7.3 13.6 0.31 11.6 0.2 3.9 3 1 1 4 4 4 0 Syntaxin 6, N-terminal HTH_24 PF13412.6 AIF82773.1 - 7.1e-08 31.9 1.3 1.5e-07 30.8 1.3 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF82773.1 - 4.8e-06 26.3 1.5 6.6e-06 25.8 0.4 1.9 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain TrmB PF01978.19 AIF82773.1 - 0.0012 18.7 0.0 0.0029 17.5 0.0 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Rnk_N PF14760.6 AIF82773.1 - 0.028 14.9 0.3 1.5 9.3 0.1 3.0 2 0 0 2 2 2 0 Rnk N-terminus Dynactin_p22 PF07426.11 AIF82773.1 - 0.05 13.5 0.6 0.32 10.9 0.0 2.2 2 1 0 2 2 2 0 Dynactin subunit p22 HTH_11 PF08279.12 AIF82773.1 - 0.062 13.3 0.4 0.21 11.6 0.1 2.1 2 0 0 2 2 2 0 HTH domain DUF4179 PF13786.6 AIF82775.1 - 0.02 15.4 0.3 0.02 15.4 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) FG-GAP PF01839.23 AIF82779.1 - 8.4e-53 176.1 75.2 2.8e-08 33.7 7.6 7.6 7 0 0 7 7 7 7 FG-GAP repeat VCBS PF13517.6 AIF82779.1 - 2.5e-25 88.9 47.8 5.5e-07 30.1 4.3 6.1 5 1 1 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 AIF82779.1 - 1.9e-11 43.7 20.9 0.15 11.4 0.2 7.3 3 1 2 7 7 7 6 Insecticide toxin TcdB middle/N-terminal region BBS2_Mid PF14783.6 AIF82779.1 - 0.12 12.4 2.9 76 3.4 0.0 5.5 7 0 0 7 7 7 0 Ciliary BBSome complex subunit 2, middle region SGP PF17228.2 AIF82779.1 - 0.96 10.3 36.0 13 6.7 0.6 7.1 5 1 2 7 7 7 0 Sulphur globule protein DUF2919 PF11143.8 AIF82781.1 - 0.013 15.8 1.1 0.029 14.7 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2919) Poly_export PF02563.16 AIF82782.1 - 0.54 10.5 4.1 1.9 8.7 0.2 3.7 3 0 0 3 3 3 0 Polysaccharide biosynthesis/export protein SoxZ PF08770.11 AIF82782.1 - 4.2 7.2 7.4 5.7 6.8 0.4 4.7 5 1 1 6 6 6 0 Sulphur oxidation protein SoxZ DUF948 PF06103.11 AIF82783.1 - 0.0021 18.3 0.1 0.0042 17.3 0.1 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 AIF82783.1 - 0.0047 17.0 2.5 0.0072 16.4 2.5 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Peptidase_C25_C PF03785.14 AIF82783.1 - 0.0067 16.2 2.1 0.23 11.3 0.0 3.1 3 0 0 3 3 3 1 Peptidase family C25, C terminal ig-like domain DUF1664 PF07889.12 AIF82783.1 - 0.0096 16.0 0.2 0.016 15.2 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Laminin_II PF06009.12 AIF82783.1 - 0.027 14.5 0.4 0.046 13.7 0.4 1.3 1 0 0 1 1 1 0 Laminin Domain II YtkA PF13115.6 AIF82783.1 - 0.03 14.9 0.0 0.23 12.1 0.0 2.4 3 1 0 3 3 3 0 YtkA-like Fzo_mitofusin PF04799.13 AIF82783.1 - 0.1 12.2 0.2 0.17 11.4 0.2 1.3 1 0 0 1 1 1 0 fzo-like conserved region LPP PF04728.13 AIF82783.1 - 1.2 9.5 4.2 1.2 9.6 0.9 2.3 1 1 1 2 2 2 0 Lipoprotein leucine-zipper Polysacc_deac_1 PF01522.21 AIF82784.1 - 4.8e-09 36.2 0.0 1e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIF82784.1 - 3.2e-07 30.2 0.2 7.1e-07 29.1 0.2 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) FRP PF18032.1 AIF82785.1 - 0.096 13.3 0.0 0.43 11.2 0.0 1.9 1 1 1 2 2 2 0 Photoprotection regulator fluorescence recovery protein Hexapep PF00132.24 AIF82786.1 - 1.3e-26 91.3 28.1 1.3e-09 37.3 7.1 4.2 4 0 0 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 AIF82786.1 - 1.1e-10 41.1 25.0 8.3e-05 22.3 0.8 4.6 3 1 1 4 4 4 3 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 AIF82786.1 - 0.00053 18.3 3.0 0.00062 18.0 3.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Glycos_transf_2 PF00535.26 AIF82787.1 - 7.3e-11 42.2 0.0 2.3e-08 34.0 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIF82787.1 - 0.00088 19.2 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AIF82787.1 - 0.022 15.3 0.1 0.14 12.7 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 2 Methyltransf_23 PF13489.6 AIF82789.1 - 3e-11 43.5 0.0 3.3e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF82789.1 - 3.6e-10 40.5 0.0 5.6e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF82789.1 - 4.1e-10 40.2 0.1 5.9e-10 39.7 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF82789.1 - 8.8e-10 38.6 0.0 1.2e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 AIF82789.1 - 2.8e-09 36.8 0.1 3.9e-09 36.4 0.1 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_25 PF13649.6 AIF82789.1 - 3.8e-09 37.1 0.1 5.3e-09 36.7 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain PDH PF02153.17 AIF82789.1 - 0.00015 20.9 0.1 0.0002 20.5 0.1 1.1 1 0 0 1 1 1 1 Prephenate dehydrogenase TPMT PF05724.11 AIF82789.1 - 0.00023 20.9 0.0 0.00028 20.6 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) TehB PF03848.14 AIF82789.1 - 0.0013 18.1 0.2 0.0026 17.2 0.2 1.6 1 1 0 1 1 1 1 Tellurite resistance protein TehB Pox_MCEL PF03291.16 AIF82789.1 - 0.0029 16.8 0.0 0.0036 16.4 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme TrkA_N PF02254.18 AIF82789.1 - 0.014 15.6 0.0 0.24 11.7 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain PrmA PF06325.13 AIF82789.1 - 0.038 13.4 0.0 0.048 13.1 0.1 1.3 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 AIF82789.1 - 0.093 12.3 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) Ribosomal_L1 PF00687.21 AIF82791.1 - 1.9e-38 132.3 0.1 2.3e-38 132.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Activator-TraM PF11657.8 AIF82791.1 - 0.037 13.9 0.2 0.1 12.4 0.1 1.7 2 0 0 2 2 2 0 Transcriptional activator TraM RL10P_insert PF17777.1 AIF82792.1 - 3e-20 72.0 0.1 6.8e-20 70.8 0.1 1.7 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 AIF82792.1 - 2.5e-19 69.2 3.1 5.6e-19 68.1 2.5 1.9 2 0 0 2 2 2 1 Ribosomal protein L10 zinc_ribbon_12 PF11331.8 AIF82793.1 - 0.17 11.7 2.5 0.45 10.4 2.5 1.7 1 1 0 1 1 1 0 Probable zinc-ribbon domain zinc_ribbon_4 PF13717.6 AIF82793.1 - 0.18 11.7 2.3 0.91 9.5 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Ribosomal_60s PF00428.19 AIF82795.1 - 9.5e-19 67.8 14.8 1.1e-18 67.6 14.8 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Qn_am_d_aIII PF09099.10 AIF82796.1 - 0.038 14.4 0.6 0.38 11.2 0.0 2.3 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III HTH_5 PF01022.20 AIF82798.1 - 0.00066 19.5 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_IclR PF09339.10 AIF82798.1 - 0.0063 16.3 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 AIF82798.1 - 0.012 15.5 0.0 0.024 14.5 0.0 1.6 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.6 AIF82798.1 - 0.017 14.9 0.1 0.055 13.3 0.1 1.9 2 1 0 2 2 2 0 Homeodomain-like domain HTH_7 PF02796.15 AIF82798.1 - 0.039 14.0 0.1 0.13 12.3 0.1 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Mga PF05043.13 AIF82798.1 - 0.041 14.5 0.1 0.085 13.5 0.0 1.6 1 1 0 1 1 1 0 Mga helix-turn-helix domain Phage_AlpA PF05930.12 AIF82798.1 - 0.048 13.5 0.1 0.13 12.1 0.0 1.8 2 0 0 2 2 2 0 Prophage CP4-57 regulatory protein (AlpA) MarR_2 PF12802.7 AIF82798.1 - 0.05 13.5 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 AIF82798.1 - 0.052 13.1 0.3 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_28 PF13518.6 AIF82798.1 - 0.072 13.2 0.0 0.3 11.2 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_27 PF13463.6 AIF82798.1 - 0.12 12.9 0.0 0.27 11.7 0.0 1.6 2 0 0 2 2 2 0 Winged helix DNA-binding domain Malic_M PF03949.15 AIF82798.1 - 0.15 11.3 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain SpoIIM PF01944.17 AIF82799.1 - 0.0073 16.4 3.9 0.0093 16.0 3.9 1.2 1 0 0 1 1 1 1 Stage II sporulation protein M MIG-14_Wnt-bd PF06664.12 AIF82799.1 - 0.0076 15.5 2.4 0.0082 15.4 2.4 1.0 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion IPTL-CTERM PF18203.1 AIF82799.1 - 1.2 9.1 10.5 0.76 9.7 2.7 2.2 2 0 0 2 2 2 0 IPTL-CTERM motif ABC2_membrane_5 PF13346.6 AIF82800.1 - 0.004 16.7 7.0 0.0045 16.6 7.0 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF3007 PF11460.8 AIF82800.1 - 0.012 15.9 0.9 0.015 15.5 0.3 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3007) DUF2304 PF10066.9 AIF82800.1 - 0.014 15.6 1.3 0.02 15.1 1.3 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) COPI_assoc PF08507.10 AIF82800.1 - 0.051 13.6 3.9 0.13 12.3 3.9 1.7 1 1 0 1 1 1 0 COPI associated protein Cupredoxin_1 PF13473.6 AIF82801.1 - 2.2e-11 43.8 0.1 4.1e-11 42.9 0.1 1.5 1 1 1 2 2 2 1 Cupredoxin-like domain Copper-bind PF00127.20 AIF82801.1 - 0.018 15.5 1.0 0.039 14.4 0.3 1.9 1 1 1 2 2 2 0 Copper binding proteins, plastocyanin/azurin family DUF4834 PF16118.5 AIF82801.1 - 0.15 13.0 0.1 0.28 12.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SSP160 PF06933.11 AIF82801.1 - 1.1 7.3 17.4 1.4 7.1 17.4 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 AIF82801.1 - 3 5.7 6.7 3.6 5.4 6.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein eIF-1a PF01176.19 AIF82802.1 - 5.3e-20 71.0 1.1 6.4e-20 70.7 1.1 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myosin_N PF02736.19 AIF82802.1 - 0.0002 21.1 0.6 0.0017 18.2 0.2 2.1 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain RsgA_N PF16745.5 AIF82802.1 - 0.0042 16.8 0.4 0.0066 16.2 0.4 1.4 1 0 0 1 1 1 1 RsgA N-terminal domain Prot_ATP_ID_OB PF16450.5 AIF82802.1 - 0.015 15.2 0.0 0.021 14.8 0.0 1.1 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain AmoC PF04896.12 AIF82803.1 - 3.5e-14 52.7 6.5 4.5e-14 52.3 6.5 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C RTA1 PF04479.13 AIF82803.1 - 0.0039 16.8 0.4 0.0064 16.1 0.4 1.3 1 0 0 1 1 1 1 RTA1 like protein DUF2975 PF11188.8 AIF82803.1 - 0.62 9.9 4.4 1.3 8.9 4.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) HicB PF05534.12 AIF82804.1 - 0.0027 17.5 0.3 0.0064 16.3 0.2 1.7 2 0 0 2 2 2 1 HicB family PP_kinase_C_1 PF17941.1 AIF82804.1 - 0.019 14.5 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Polyphosphate kinase C-terminal domain 1 BrnA_antitoxin PF14384.6 AIF82804.1 - 0.15 12.5 0.0 0.31 11.6 0.0 1.5 1 0 0 1 1 1 0 BrnA antitoxin of type II toxin-antitoxin system FUN14 PF04930.15 AIF82805.1 - 6.1e-18 65.0 7.5 7.3e-18 64.8 7.5 1.1 1 0 0 1 1 1 1 FUN14 family SPC12 PF06645.13 AIF82805.1 - 0.64 10.2 7.8 0.33 11.0 3.7 2.2 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Trp_oprn_chp PF09534.10 AIF82805.1 - 1.3 8.8 8.7 1.6 8.5 8.7 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Vma12 PF11712.8 AIF82805.1 - 1.9 8.5 4.1 13 5.9 2.9 2.0 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4438 PF14505.6 AIF82806.1 - 0.22 10.5 0.0 0.26 10.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4438) Yip1 PF04893.17 AIF82806.1 - 0.6 9.8 26.0 0.89 9.2 26.0 1.3 1 0 0 1 1 1 0 Yip1 domain YrhC PF14143.6 AIF82806.1 - 3.3 7.9 5.9 12 6.0 0.4 2.6 2 1 0 2 2 2 0 YrhC-like protein DUF2070 PF09843.9 AIF82806.1 - 8.2 4.6 17.3 9.4 4.4 17.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) B12-binding_2 PF02607.17 AIF82807.1 - 1.2e-07 32.0 0.1 2.8e-07 30.9 0.1 1.6 1 0 0 1 1 1 1 B12 binding domain HTH_11 PF08279.12 AIF82807.1 - 1.5e-06 28.0 0.1 2.6e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 AIF82807.1 - 1.3e-05 24.7 0.1 2.1e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding DUF2250 PF10007.9 AIF82807.1 - 0.00044 20.3 0.1 0.00085 19.4 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2250) MarR PF01047.22 AIF82807.1 - 0.0048 16.8 0.1 0.0098 15.8 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_5 PF01022.20 AIF82807.1 - 0.0058 16.5 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family Mnd1 PF03962.15 AIF82807.1 - 0.012 15.9 0.1 0.024 14.9 0.1 1.5 1 0 0 1 1 1 0 Mnd1 HTH domain GntR PF00392.21 AIF82807.1 - 0.012 15.3 0.0 0.024 14.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family RepL PF05732.11 AIF82807.1 - 0.044 13.2 0.3 0.08 12.4 0.3 1.3 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) HTH_IclR PF09339.10 AIF82807.1 - 0.061 13.1 0.0 0.25 11.2 0.0 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain Dimerisation2 PF16864.5 AIF82807.1 - 0.068 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain ACT_7 PF13840.6 AIF82808.1 - 4.8e-06 26.3 0.0 1.1e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 ACT domain CT_C_D PF02682.16 AIF82808.1 - 0.045 13.5 0.6 0.23 11.2 0.2 1.9 1 1 1 2 2 2 0 Carboxyltransferase domain, subdomain C and D Arginosuc_synth PF00764.19 AIF82809.1 - 6.7e-162 539.2 0.5 7.8e-162 539.0 0.5 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.21 AIF82809.1 - 0.00096 18.9 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.13 AIF82809.1 - 0.013 15.0 0.1 0.032 13.7 0.0 1.7 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 AIF82809.1 - 0.078 11.7 0.1 0.15 10.8 0.1 1.6 1 0 0 1 1 1 0 tRNA methyl transferase zinc_ribbon_4 PF13717.6 AIF82810.1 - 2.6e-05 24.0 0.8 0.16 11.9 0.1 2.1 1 1 1 2 2 2 2 zinc-ribbon domain zf-IS66 PF13005.7 AIF82810.1 - 0.00021 21.6 1.5 0.034 14.5 0.1 2.1 2 0 0 2 2 2 1 zinc-finger binding domain of transposase IS66 YhfH PF14149.6 AIF82810.1 - 0.00092 19.1 3.5 0.037 14.0 0.7 2.1 2 0 0 2 2 2 1 YhfH-like protein Zn-ribbon_8 PF09723.10 AIF82810.1 - 0.0012 18.9 7.7 0.018 15.1 2.8 1.9 1 1 1 2 2 2 2 Zinc ribbon domain zf-ribbon_3 PF13248.6 AIF82810.1 - 0.0031 16.9 2.2 0.98 8.9 0.2 2.1 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 AIF82810.1 - 0.0043 17.1 0.3 0.0052 16.8 0.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_9 PF14369.6 AIF82810.1 - 0.0073 16.5 1.5 0.015 15.6 1.5 1.5 1 1 0 1 1 1 1 zinc-ribbon HypA PF01155.19 AIF82810.1 - 0.01 15.8 0.4 0.011 15.8 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_UBZ PF18439.1 AIF82810.1 - 0.014 15.0 1.2 4 7.1 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C4_Topoisom PF01396.19 AIF82810.1 - 0.014 15.1 1.9 1.2 9.0 0.0 2.1 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger DUF1272 PF06906.11 AIF82810.1 - 0.018 15.1 4.3 1.1 9.4 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1272) zinc_ribbon_5 PF13719.6 AIF82810.1 - 0.021 14.6 0.4 0.18 11.6 0.0 2.0 2 0 0 2 2 2 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 AIF82810.1 - 0.024 14.6 0.1 0.045 13.7 0.1 1.4 1 1 0 1 1 1 0 PhnA Zinc-Ribbon zf_Rg PF17915.1 AIF82810.1 - 0.031 13.7 0.9 0.4 10.1 0.0 2.1 2 0 0 2 2 2 0 Reverse gyrase zinc finger DNA_RNApol_7kD PF03604.13 AIF82810.1 - 0.034 13.8 5.2 0.51 10.1 3.9 2.7 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-HYPF PF07503.12 AIF82810.1 - 0.048 13.4 1.9 0.57 10.0 1.9 2.0 1 1 0 1 1 1 0 HypF finger OrfB_Zn_ribbon PF07282.11 AIF82810.1 - 0.057 13.3 0.2 0.081 12.9 0.2 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Prok-RING_1 PF14446.6 AIF82810.1 - 0.06 13.3 7.6 0.3 11.1 7.6 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 DUF1451 PF07295.11 AIF82810.1 - 0.062 13.3 0.6 0.092 12.8 0.6 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain Nop10p PF04135.12 AIF82810.1 - 0.08 13.0 0.7 12 6.1 0.1 2.2 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family CpXC PF14353.6 AIF82810.1 - 0.086 12.9 0.9 2.4 8.2 0.1 2.0 1 1 0 2 2 2 0 CpXC protein Lar_restr_allev PF14354.6 AIF82810.1 - 0.094 13.1 2.2 0.25 11.7 2.2 1.7 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-RING_7 PF02591.15 AIF82810.1 - 0.1 12.8 0.4 0.1 12.8 0.4 2.4 3 0 0 3 3 2 0 C4-type zinc ribbon domain DUF983 PF06170.12 AIF82810.1 - 0.25 11.8 3.2 5.5 7.5 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF983) PADR1 PF08063.12 AIF82810.1 - 0.57 10.0 3.1 1.3 8.9 0.1 2.1 1 1 1 2 2 2 0 PADR1 (NUC008) domain RimK PF08443.11 AIF82811.1 - 6.8e-36 123.6 0.0 9e-36 123.2 0.0 1.1 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 AIF82811.1 - 4.7e-13 48.9 0.0 7.5e-13 48.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.14 AIF82811.1 - 6.6e-11 42.5 0.0 2e-10 40.9 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_ST PF14397.6 AIF82811.1 - 7.6e-09 35.2 0.1 0.00096 18.5 0.0 2.6 1 1 2 3 3 3 2 Sugar-transfer associated ATP-grasp ATP-grasp PF02222.22 AIF82811.1 - 9.6e-07 28.5 0.0 2.1e-06 27.4 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_YheCD PF14398.6 AIF82811.1 - 2.7e-06 26.8 0.0 0.022 14.0 0.0 3.0 1 1 0 1 1 1 1 YheC/D like ATP-grasp CPSase_L_D2 PF02786.17 AIF82811.1 - 0.0001 21.9 0.0 0.0002 21.0 0.0 1.5 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_5 PF13549.6 AIF82811.1 - 0.0018 17.8 0.0 0.0043 16.5 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 AIF82811.1 - 0.016 14.8 0.0 0.047 13.2 0.0 1.9 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus Semialdhyde_dh PF01118.24 AIF82812.1 - 6.5e-38 129.9 0.0 1.3e-37 128.9 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 AIF82812.1 - 1.5e-22 80.5 0.0 2.2e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain F420_oxidored PF03807.17 AIF82812.1 - 0.00035 21.1 0.0 0.00079 20.0 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 AIF82812.1 - 0.00082 19.5 0.1 0.0017 18.4 0.1 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_10 PF13460.6 AIF82812.1 - 0.0032 17.4 0.0 0.0073 16.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding GFO_IDH_MocA PF01408.22 AIF82812.1 - 0.0084 16.9 0.0 0.016 16.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Sacchrp_dh_NADP PF03435.18 AIF82812.1 - 0.045 14.0 0.0 0.083 13.2 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 AIF82812.1 - 0.066 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RPN6_N PF18055.1 AIF82812.1 - 0.07 13.5 0.0 0.28 11.5 0.0 1.9 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain AA_kinase PF00696.28 AIF82813.1 - 1.6e-38 132.7 4.7 1.8e-38 132.5 4.7 1.0 1 0 0 1 1 1 1 Amino acid kinase family Aminotran_3 PF00202.21 AIF82814.1 - 2.2e-113 379.0 0.0 3.1e-113 378.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 AIF82814.1 - 0.00017 20.9 0.0 0.00058 19.1 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AIF82814.1 - 0.00026 20.1 0.0 0.00038 19.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V HTH_AsnC-type PF13404.6 AIF82815.1 - 4e-16 58.6 0.8 7.8e-16 57.6 0.3 1.7 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 AIF82815.1 - 1.6e-15 56.3 0.5 4.5e-15 54.9 0.3 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 AIF82815.1 - 4.1e-11 42.7 0.2 6.5e-11 42.0 0.2 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIF82815.1 - 4.8e-06 26.5 3.8 6.1e-05 23.0 0.9 2.2 2 0 0 2 2 2 1 NapD protein HTH_5 PF01022.20 AIF82815.1 - 4.6e-05 23.2 0.0 0.00033 20.4 0.0 2.2 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.12 AIF82815.1 - 0.00024 21.0 0.2 0.00063 19.6 0.2 1.7 1 0 0 1 1 1 1 HTH domain MarR_2 PF12802.7 AIF82815.1 - 0.00041 20.2 0.3 0.0019 18.0 0.1 2.0 1 1 1 2 2 2 1 MarR family HTH_IclR PF09339.10 AIF82815.1 - 0.00051 19.8 0.0 0.00092 19.0 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_Tnp_ISL3 PF13542.6 AIF82815.1 - 0.0026 17.1 0.0 0.0081 15.6 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 TrmB PF01978.19 AIF82815.1 - 0.0033 17.3 0.3 0.034 14.0 0.0 2.1 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 AIF82815.1 - 0.012 15.5 0.4 0.038 13.9 0.1 1.9 2 0 0 2 2 2 0 MarR family HTH_20 PF12840.7 AIF82815.1 - 0.015 15.3 0.0 0.041 13.9 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_47 PF16221.5 AIF82815.1 - 0.032 13.8 0.5 0.06 12.9 0.1 1.8 2 0 0 2 2 2 0 winged helix-turn-helix GYD PF08734.11 AIF82815.1 - 0.039 13.9 0.1 0.1 12.6 0.0 1.6 1 1 0 1 1 1 0 GYD domain CinA_KH PF18146.1 AIF82815.1 - 0.056 13.6 0.3 0.12 12.6 0.1 1.7 2 0 0 2 2 1 0 Damage-inducible protein CinA KH domain FaeA PF04703.12 AIF82815.1 - 0.065 13.6 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 FaeA-like protein Sigma70_r4 PF04545.16 AIF82815.1 - 0.076 12.5 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Rrf2 PF02082.20 AIF82815.1 - 0.088 13.2 0.2 0.54 10.7 0.0 2.1 1 1 1 2 2 2 0 Transcriptional regulator HTH_Crp_2 PF13545.6 AIF82815.1 - 0.11 12.5 0.1 0.39 10.7 0.1 1.9 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_36 PF13730.6 AIF82815.1 - 0.13 12.3 0.0 0.54 10.3 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Mga PF05043.13 AIF82815.1 - 0.16 12.5 0.0 0.33 11.6 0.0 1.5 1 1 0 1 1 1 0 Mga helix-turn-helix domain HTH_6 PF01418.17 AIF82815.1 - 0.17 11.9 0.1 0.17 11.9 0.1 2.5 2 1 1 3 3 3 0 Helix-turn-helix domain, rpiR family HTH_AraC PF00165.23 AIF82815.1 - 0.18 11.9 0.0 0.75 10.0 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix proteins, AraC family Saf_2TM PF18303.1 AIF82816.1 - 3.6 7.2 7.7 5 6.7 3.5 2.1 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DUF4367 PF14285.6 AIF82817.1 - 0.034 14.6 0.3 0.047 14.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) Methyltransf_11 PF08241.12 AIF82818.1 - 1.2e-13 51.5 0.0 2e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF82818.1 - 6.6e-09 36.4 0.0 1.1e-08 35.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF82818.1 - 2.4e-06 27.5 0.0 3.2e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AIF82818.1 - 0.00011 21.7 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 AIF82818.1 - 0.00047 19.7 0.1 0.0022 17.6 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 AIF82818.1 - 0.00089 20.0 0.0 0.0015 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AIF82818.1 - 0.0086 15.8 0.1 0.019 14.7 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 AIF82818.1 - 0.03 14.1 0.0 0.062 13.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 AIF82818.1 - 0.099 12.6 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 AIF82818.1 - 0.19 11.0 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Dimerisation2 PF16864.5 AIF82819.1 - 9.2e-06 25.6 0.0 1.3e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Dimerisation domain Nitroreductase PF00881.24 AIF82820.1 - 1.3e-24 87.1 0.4 9.9e-12 45.2 0.0 2.1 1 1 1 2 2 2 2 Nitroreductase family TM1586_NiRdase PF14512.6 AIF82820.1 - 3.3e-10 39.9 0.0 1.2e-05 25.0 0.0 2.1 1 1 1 2 2 2 2 Putative TM nitroreductase zf-CDGSH PF09360.10 AIF82821.1 - 3.8e-39 132.7 1.4 1.8e-19 69.7 0.1 2.6 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type Fer4_19 PF06902.11 AIF82821.1 - 5.8e-06 26.3 0.0 1.4e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Divergent 4Fe-4S mono-cluster zf-UBR PF02207.20 AIF82821.1 - 0.057 13.6 4.3 2.7 8.2 0.1 2.3 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) MSL2-CXC PF16682.5 AIF82821.1 - 0.83 9.8 5.8 9.7 6.4 0.6 2.5 2 0 0 2 2 2 0 CXC domain of E3 ubiquitin-protein ligase MSL2 Abhydrolase_3 PF07859.13 AIF82822.1 - 7.9e-73 244.8 0.0 1e-72 244.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 AIF82822.1 - 0.00022 20.2 0.9 0.0007 18.6 0.9 1.7 1 1 0 1 1 1 1 Carboxylesterase family Chlorophyllase2 PF12740.7 AIF82822.1 - 0.00043 19.3 0.0 0.00064 18.7 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 AIF82822.1 - 0.00066 19.2 0.1 0.0024 17.4 0.1 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 AIF82822.1 - 0.0012 17.8 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase PF07224.11 AIF82822.1 - 0.0018 17.3 0.0 0.0026 16.8 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase AXE1 PF05448.12 AIF82822.1 - 0.0056 15.4 0.0 0.02 13.6 0.0 1.8 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Esterase PF00756.20 AIF82822.1 - 0.016 14.9 0.3 0.53 9.9 0.3 2.1 1 1 0 1 1 1 0 Putative esterase Ribosomal_L15e PF00827.17 AIF82825.1 - 2.8e-49 167.5 4.1 3.3e-49 167.2 4.1 1.0 1 0 0 1 1 1 1 Ribosomal L15 OrfB_IS605 PF01385.19 AIF82827.1 - 1.6e-21 76.7 0.8 3.3e-21 75.7 0.8 1.4 1 0 0 1 1 1 1 Probable transposase OrfB_Zn_ribbon PF07282.11 AIF82827.1 - 1.9e-17 62.9 0.5 4.2e-17 61.8 0.5 1.6 1 0 0 1 1 1 1 Putative transposase DNA-binding domain HTH_OrfB_IS605 PF12323.8 AIF82827.1 - 2.5e-09 36.5 1.6 7.9e-09 34.9 1.6 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HypA PF01155.19 AIF82827.1 - 0.012 15.6 0.8 0.041 13.9 0.3 2.0 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TF_Zn_Ribbon PF08271.12 AIF82827.1 - 0.023 14.2 1.4 6 6.5 0.3 2.6 2 0 0 2 2 2 0 TFIIB zinc-binding C1_1 PF00130.22 AIF82827.1 - 0.03 14.2 0.8 0.073 13.0 0.8 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PP28 PF10252.9 AIF82827.1 - 0.033 14.6 0.7 0.084 13.3 0.7 1.7 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 Oleosin PF01277.17 AIF82827.1 - 0.3 10.9 0.3 5.1 6.9 0.0 2.5 2 1 1 3 3 3 0 Oleosin DUF1451 PF07295.11 AIF82827.1 - 2.5 8.1 4.9 2.9 7.9 2.7 2.1 2 0 0 2 2 2 0 Zinc-ribbon containing domain 2-Hacid_dh_C PF02826.19 AIF82828.1 - 3.9e-65 218.5 0.0 1.9e-64 216.3 0.0 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 AIF82828.1 - 8.8e-31 106.3 0.3 9.9e-31 106.2 0.3 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 AIF82828.1 - 3.5e-06 27.3 0.2 2.3e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 AIF82828.1 - 0.0033 17.9 0.0 0.055 14.0 0.0 2.4 2 0 0 2 2 2 1 XdhC Rossmann domain F420_oxidored PF03807.17 AIF82828.1 - 0.084 13.5 2.3 5.4 7.7 0.2 2.9 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent DUF1326 PF07040.11 AIF82830.1 - 2.9e-54 183.8 0.0 3.3e-54 183.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) DUF1326 PF07040.11 AIF82832.1 - 1.9e-48 164.8 0.0 2.2e-48 164.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) DUF2182 PF09948.9 AIF82833.1 - 8.5e-59 198.6 15.1 8.5e-59 198.6 15.1 2.2 2 1 0 2 2 2 1 Predicted metal-binding integral membrane protein (DUF2182) DUF1195 PF06708.11 AIF82833.1 - 0.12 12.1 0.2 0.24 11.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) Lig_chan PF00060.26 AIF82833.1 - 0.45 10.3 4.0 2.1 8.2 4.0 2.1 1 1 0 1 1 1 0 Ligand-gated ion channel SurA_N_3 PF13624.6 AIF82835.1 - 0.015 15.1 0.1 0.017 14.9 0.1 1.1 1 0 0 1 1 1 0 SurA N-terminal domain Sensor_TM1 PF13755.6 AIF82836.1 - 0.039 13.7 1.1 4.3 7.2 0.0 2.5 2 0 0 2 2 2 0 Sensor N-terminal transmembrane domain DUF543 PF04418.12 AIF82836.1 - 0.9 9.6 4.8 0.56 10.2 1.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF543) DUF4231 PF14015.6 AIF82836.1 - 9 6.8 6.4 7.9 7.0 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Lyase_1 PF00206.20 AIF82837.1 - 6.8e-90 301.6 0.2 9e-90 301.2 0.2 1.2 1 0 0 1 1 1 1 Lyase Acetyltransf_3 PF13302.7 AIF82837.1 - 6.2e-29 101.4 0.0 1.1e-28 100.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FumaraseC_C PF10415.9 AIF82837.1 - 3.9e-20 72.0 0.5 1.2e-19 70.4 0.5 2.0 1 0 0 1 1 1 1 Fumarase C C-terminus Acetyltransf_4 PF13420.7 AIF82837.1 - 6.7e-09 36.1 0.0 2.4e-08 34.3 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AIF82837.1 - 3.6e-08 33.6 0.1 7.5e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 AIF82837.1 - 0.0059 16.3 0.0 0.043 13.5 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF4316 PF14195.6 AIF82837.1 - 0.027 14.2 0.2 3.1 7.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4316) CitMHS PF03600.16 AIF82838.1 - 2 7.6 8.4 2.7 7.1 8.4 1.2 1 0 0 1 1 1 0 Citrate transporter DUF488 PF04343.13 AIF82839.1 - 4.5e-28 98.3 0.4 5.1e-28 98.1 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF488 ADH_N PF08240.12 AIF82840.1 - 3.8e-33 113.6 0.2 6.5e-33 112.9 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIF82840.1 - 1.4e-26 93.0 3.4 1.7e-26 92.7 0.7 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AIF82840.1 - 7.6e-14 52.9 0.1 1.5e-13 51.9 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AIF82840.1 - 2.8e-05 23.7 1.2 0.00014 21.5 1.2 1.8 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 AIF82840.1 - 0.0003 20.2 3.3 0.00044 19.6 3.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 AIF82840.1 - 0.008 16.7 0.6 0.29 11.7 0.7 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase PglD_N PF17836.1 AIF82840.1 - 0.011 16.4 1.1 0.021 15.4 1.1 1.6 1 0 0 1 1 1 0 PglD N-terminal domain TrkA_N PF02254.18 AIF82840.1 - 0.017 15.4 0.3 0.038 14.3 0.3 1.5 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 AIF82840.1 - 0.022 14.3 0.7 0.034 13.7 0.7 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 AIF82840.1 - 0.027 13.8 0.4 0.056 12.8 0.4 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glyco_hydro_4 PF02056.16 AIF82840.1 - 0.097 12.2 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase Spermine_synth PF01564.17 AIF82840.1 - 0.13 11.7 0.2 0.24 10.8 0.2 1.4 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Abhydrolase_1 PF00561.20 AIF82841.1 - 1.5e-27 96.9 0.1 5.7e-25 88.4 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIF82841.1 - 2e-26 94.0 0.0 2.5e-26 93.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AIF82841.1 - 5.8e-19 68.3 0.0 1.1e-18 67.3 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 AIF82841.1 - 1.9e-06 26.8 0.0 1.7e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 Ndr family DUF1057 PF06342.12 AIF82841.1 - 4.6e-05 22.6 0.0 0.00012 21.3 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) DUF676 PF05057.14 AIF82841.1 - 0.00011 21.8 0.0 0.00043 19.9 0.0 1.9 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.7 AIF82841.1 - 0.00013 21.8 0.0 0.1 12.4 0.1 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 AIF82841.1 - 0.00019 20.5 0.0 0.0013 17.7 0.0 1.9 2 0 0 2 2 2 1 Chlorophyllase enzyme Abhydrolase_2 PF02230.16 AIF82841.1 - 0.0017 18.2 0.3 0.57 9.9 0.0 3.0 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase LIDHydrolase PF10230.9 AIF82841.1 - 0.002 17.7 0.0 0.0026 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase PGAP1 PF07819.13 AIF82841.1 - 0.0026 17.5 0.3 0.34 10.6 0.6 2.6 1 1 1 2 2 2 1 PGAP1-like protein UPF0227 PF05728.12 AIF82841.1 - 0.0046 16.9 1.2 0.013 15.4 0.1 2.1 2 1 0 2 2 1 1 Uncharacterised protein family (UPF0227) FSH1 PF03959.13 AIF82841.1 - 0.0048 16.6 0.0 0.063 12.9 0.0 2.5 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 AIF82841.1 - 0.0051 16.3 0.0 0.21 11.0 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 AIF82841.1 - 0.0056 16.6 0.0 0.009 15.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 AIF82841.1 - 0.0098 16.0 0.0 0.013 15.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 AIF82841.1 - 0.018 14.7 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Palm_thioest PF02089.15 AIF82841.1 - 0.023 14.5 0.0 0.054 13.3 0.0 1.6 1 1 0 1 1 1 0 Palmitoyl protein thioesterase Chlorophyllase PF07224.11 AIF82841.1 - 0.024 13.7 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase BAAT_C PF08840.11 AIF82841.1 - 0.038 13.9 0.0 0.073 13.0 0.0 1.5 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 AIF82841.1 - 0.039 13.5 0.0 7.5 6.0 0.0 2.4 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_4 PF08386.10 AIF82841.1 - 0.039 14.1 0.0 0.087 12.9 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Abhydro_lipase PF04083.16 AIF82841.1 - 0.052 13.1 0.0 0.18 11.4 0.0 1.8 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Lipase_3 PF01764.25 AIF82841.1 - 0.11 12.4 0.0 0.56 10.1 0.0 2.0 2 0 0 2 2 2 0 Lipase (class 3) Peptidase_S15 PF02129.18 AIF82841.1 - 0.14 11.7 0.0 1.8 8.1 0.0 2.0 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Ser_hydrolase PF06821.13 AIF82841.1 - 0.16 11.8 0.0 0.56 10.0 0.0 1.9 2 0 0 2 2 2 0 Serine hydrolase Aldedh PF00171.22 AIF82842.1 - 4e-148 493.8 0.3 4.5e-148 493.6 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 AIF82842.1 - 0.0026 16.9 0.0 0.0039 16.3 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) ALAD PF00490.21 AIF82843.1 - 2.2e-113 378.6 1.0 2.6e-113 378.4 1.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase CorA PF01544.18 AIF82844.1 - 4.8e-56 190.2 0.8 5.4e-56 190.0 0.8 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MnmE_helical PF12631.7 AIF82844.1 - 0.021 15.0 1.6 0.73 10.0 0.1 2.1 1 1 1 2 2 2 0 MnmE helical domain DUF3685 PF12452.8 AIF82844.1 - 0.059 13.1 0.4 0.15 11.8 0.1 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3685) SnoaL_2 PF12680.7 AIF82847.1 - 2.8e-12 47.2 0.0 3e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIF82847.1 - 1.1e-07 32.1 0.0 1.3e-07 32.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL PF07366.12 AIF82847.1 - 2e-05 24.4 0.0 2.5e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_3 PF13474.6 AIF82847.1 - 7.8e-05 22.9 0.0 8.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain NTF2 PF02136.20 AIF82847.1 - 0.04 14.5 0.0 0.047 14.3 0.0 1.1 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain SnoaL_4 PF13577.6 AIF82847.1 - 0.1 12.7 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like domain DUF4878 PF12870.7 AIF82847.1 - 0.14 12.4 0.0 0.15 12.3 0.0 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4878) CaMKII_AD PF08332.10 AIF82847.1 - 0.24 11.5 0.0 0.33 11.1 0.0 1.2 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain EFP_N PF08207.12 AIF82848.1 - 1.9e-09 37.4 0.1 1.9e-06 27.8 0.0 2.4 2 0 0 2 2 2 2 Elongation factor P (EF-P) KOW-like domain eIF-5a PF01287.20 AIF82848.1 - 1.8e-05 24.7 1.9 2.5e-05 24.3 1.9 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GH101_N PF17995.1 AIF82848.1 - 0.0059 16.3 0.1 0.009 15.7 0.1 1.2 1 0 0 1 1 1 1 Endo-alpha-N-acetylgalactosaminidase N-terminal EFP PF01132.20 AIF82848.1 - 0.073 13.1 0.0 0.26 11.4 0.1 1.9 2 0 0 2 2 2 0 Elongation factor P (EF-P) OB domain BPD_transp_1 PF00528.22 AIF82849.1 - 6.3e-26 91.2 10.1 6.3e-26 91.2 10.1 1.8 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 AIF82849.1 - 0.045 13.7 0.1 0.045 13.7 0.1 2.7 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C BPD_transp_1 PF00528.22 AIF82850.1 - 1.4e-36 126.0 13.9 1.4e-36 126.0 13.9 1.6 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component SBP_bac_5 PF00496.22 AIF82851.1 - 3.8e-18 65.6 1.3 3.8e-18 65.6 1.3 2.7 2 1 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 5 Middle ABC_tran PF00005.27 AIF82852.1 - 1.5e-31 109.7 0.0 2e-31 109.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 AIF82852.1 - 3.1e-06 27.6 0.0 5.4e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_22 PF13401.6 AIF82852.1 - 2.2e-05 24.7 0.2 0.00012 22.3 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIF82852.1 - 3.4e-05 24.3 0.0 5.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 AIF82852.1 - 0.0003 20.1 0.2 0.0011 18.3 0.0 1.9 1 1 1 2 2 2 1 Zeta toxin AAA_5 PF07728.14 AIF82852.1 - 0.013 15.5 0.1 0.063 13.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 AIF82852.1 - 0.015 15.3 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 AIF82852.1 - 0.016 15.0 0.1 0.034 13.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 AIF82852.1 - 0.016 15.1 0.6 2.5 7.8 0.1 2.1 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 AIF82852.1 - 0.018 14.7 0.7 0.17 11.6 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AIF82852.1 - 0.022 14.9 0.2 0.033 14.4 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 AIF82852.1 - 0.025 15.0 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 AIF82852.1 - 0.049 13.4 0.0 1.8 8.3 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein RsgA_GTPase PF03193.16 AIF82852.1 - 0.049 13.5 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 AIF82852.1 - 0.062 12.9 1.0 0.12 11.9 0.1 1.8 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 AIF82852.1 - 0.063 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 AIF82852.1 - 0.069 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 AIF82852.1 - 0.081 12.6 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 AIF82852.1 - 0.092 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_18 PF13238.6 AIF82852.1 - 0.1 13.2 0.1 0.2 12.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 AIF82852.1 - 0.13 12.1 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Diphthami_syn_2 PF01902.17 AIF82853.1 - 4.3e-63 212.7 0.0 4.9e-63 212.6 0.0 1.0 1 0 0 1 1 1 1 Diphthamide synthase QueC PF06508.13 AIF82853.1 - 0.035 13.6 0.0 0.053 13.0 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 AIF82853.1 - 0.12 11.1 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase SRP54 PF00448.22 AIF82854.1 - 5.6e-70 235.0 0.2 8.8e-70 234.3 0.2 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 AIF82854.1 - 8.4e-25 87.3 8.9 9.1e-24 84.0 6.0 2.5 2 0 0 2 2 2 1 Signal peptide binding domain SRP54_N PF02881.19 AIF82854.1 - 6.1e-15 55.2 0.3 1.7e-14 53.8 0.3 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 AIF82854.1 - 9.5e-07 28.9 0.0 3.1e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 AIF82854.1 - 2.7e-05 24.4 0.1 9.4e-05 22.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain MeaB PF03308.16 AIF82854.1 - 4.3e-05 22.6 1.5 6.4e-05 22.1 0.2 1.9 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 AIF82854.1 - 0.0001 22.2 0.1 0.00026 20.9 0.1 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.19 AIF82854.1 - 0.00024 20.7 0.6 0.0064 16.1 0.6 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ParA PF10609.9 AIF82854.1 - 0.00027 20.5 0.1 0.00081 18.9 0.0 1.7 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase APS_kinase PF01583.20 AIF82854.1 - 0.00056 19.8 0.1 0.0013 18.7 0.1 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_30 PF13604.6 AIF82854.1 - 0.00089 19.0 0.7 0.002 17.9 0.1 1.9 2 0 0 2 2 1 1 AAA domain CLP1_P PF16575.5 AIF82854.1 - 0.0014 18.5 0.0 0.13 12.1 0.0 2.9 2 1 1 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA PF00004.29 AIF82854.1 - 0.0015 18.9 0.0 0.012 16.0 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MipZ PF09140.11 AIF82854.1 - 0.0023 17.3 0.4 0.28 10.4 0.4 2.5 1 1 0 1 1 1 1 ATPase MipZ AAA_17 PF13207.6 AIF82854.1 - 0.003 18.0 0.1 0.017 15.5 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AIF82854.1 - 0.0034 17.6 0.5 0.0084 16.3 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.6 AIF82854.1 - 0.0036 17.7 0.0 0.011 16.1 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 AIF82854.1 - 0.004 17.2 0.1 0.02 15.0 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_26 PF13500.6 AIF82854.1 - 0.0041 17.0 0.2 0.3 10.9 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_31 PF13614.6 AIF82854.1 - 0.0043 17.0 0.1 0.025 14.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 AIF82854.1 - 0.0043 16.3 2.3 0.043 13.0 0.1 2.9 3 0 0 3 3 3 1 Anion-transporting ATPase NTPase_1 PF03266.15 AIF82854.1 - 0.0067 16.4 0.6 0.036 14.0 0.6 2.2 1 1 0 1 1 1 1 NTPase Thymidylate_kin PF02223.17 AIF82854.1 - 0.0073 16.0 0.1 0.018 14.7 0.1 1.6 1 0 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 AIF82854.1 - 0.01 16.4 0.0 0.037 14.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AIF82854.1 - 0.016 14.9 0.0 0.034 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 AIF82854.1 - 0.019 14.4 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 PduV-EutP PF10662.9 AIF82854.1 - 0.019 14.7 0.1 4.8 6.9 0.1 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation LpxK PF02606.14 AIF82854.1 - 0.025 13.7 0.5 0.048 12.8 0.5 1.4 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase 6PF2K PF01591.18 AIF82854.1 - 0.026 13.8 0.0 0.069 12.5 0.0 1.7 1 0 0 1 1 1 0 6-phosphofructo-2-kinase LPD22 PF18834.1 AIF82854.1 - 0.03 14.5 0.1 0.18 12.0 0.0 2.2 2 0 0 2 2 2 0 Large polyvalent protein associated domain 22 ATP_bind_1 PF03029.17 AIF82854.1 - 0.04 13.7 0.0 0.08 12.7 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 AIF82854.1 - 0.047 13.7 0.6 0.23 11.5 0.1 2.4 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) LytR_C PF13399.6 AIF82854.1 - 0.048 14.7 0.0 1.1 10.3 0.0 2.5 2 0 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator Mur_ligase_M PF08245.12 AIF82854.1 - 0.075 13.0 0.5 0.17 11.8 0.5 1.6 1 1 0 1 1 1 0 Mur ligase middle domain Zeta_toxin PF06414.12 AIF82854.1 - 0.079 12.2 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 AIF82854.1 - 0.098 12.9 0.2 0.22 11.7 0.2 1.6 1 0 0 1 1 1 0 AAA domain DUF1611 PF07755.11 AIF82854.1 - 0.11 11.7 0.7 0.22 10.8 0.1 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF1611_C) P-loop domain Radical_SAM_N PF08497.10 AIF82854.1 - 0.11 11.7 0.2 0.62 9.3 0.0 2.0 2 0 0 2 2 2 0 Radical SAM N-terminal SRPRB PF09439.10 AIF82854.1 - 0.14 11.6 0.1 0.83 9.1 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit IstB_IS21 PF01695.17 AIF82854.1 - 0.17 11.6 0.5 0.52 10.0 0.1 2.0 2 1 1 3 3 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 AIF82854.1 - 0.21 11.1 1.2 1.1 8.9 1.2 2.2 1 1 0 1 1 1 0 AAA domain THUMP PF02926.17 AIF82855.1 - 0.00016 21.8 0.0 0.00086 19.4 0.0 2.0 2 0 0 2 2 2 1 THUMP domain C5-epim_C PF06662.13 AIF82856.1 - 6.3e-30 104.1 2.0 9.4e-30 103.5 2.0 1.2 1 0 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.13 AIF82856.1 - 0.22 10.5 5.9 0.68 8.9 1.7 2.6 2 2 1 3 3 3 0 Glycosyl Hydrolase Family 88 SP_C-Propep PF08999.10 AIF82857.1 - 0.045 13.5 3.2 0.046 13.5 3.2 1.2 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide DUF3149 PF11346.8 AIF82857.1 - 3.1 7.5 8.7 0.34 10.6 2.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) DNA_pol3_tau_4 PF12168.8 AIF82858.1 - 0.09 13.3 0.3 16 6.1 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase III subunits tau domain IV DnaB-binding Afi1 PF07792.12 AIF82858.1 - 0.7 10.4 13.7 1 9.8 13.7 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Polbeta PF18765.1 AIF82860.1 - 8.3e-08 32.2 0.0 2.3e-07 30.8 0.1 1.8 1 1 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 AIF82860.1 - 1.5e-06 28.4 0.2 3.2e-06 27.3 0.2 1.6 1 1 0 1 1 1 1 Nucleotidyltransferase domain RIO1 PF01163.22 AIF82860.1 - 0.019 14.6 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 AIF82860.1 - 0.063 12.6 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_S27 PF01599.19 AIF82861.1 - 4.1e-21 74.9 7.5 6.5e-21 74.2 7.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S27a DUF1451 PF07295.11 AIF82861.1 - 0.0017 18.4 1.6 0.0019 18.3 1.6 1.1 1 0 0 1 1 1 1 Zinc-ribbon containing domain IBR PF01485.21 AIF82861.1 - 0.0033 17.6 0.7 0.0041 17.3 0.7 1.1 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain Ribosomal_L37e PF01907.19 AIF82861.1 - 0.0046 17.1 3.4 0.0057 16.8 3.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e GFA PF04828.14 AIF82861.1 - 0.012 16.0 2.4 0.094 13.1 0.2 2.0 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Ephrin_rec_like PF07699.13 AIF82861.1 - 0.022 14.5 0.8 0.029 14.1 0.8 1.2 1 0 0 1 1 1 0 Putative ephrin-receptor like zinc_ribbon_13 PF09855.9 AIF82861.1 - 0.031 14.4 3.5 0.083 13.1 0.3 2.3 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Nudix_N_2 PF14803.6 AIF82861.1 - 0.031 14.2 1.8 0.15 12.0 1.8 2.0 1 1 0 1 1 1 0 Nudix N-terminal C1_1 PF00130.22 AIF82861.1 - 0.039 13.9 1.8 0.053 13.4 1.8 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Baculo_ME53 PF06061.11 AIF82861.1 - 0.052 12.8 2.0 0.057 12.6 2.0 1.0 1 0 0 1 1 1 0 Baculoviridae ME53 HypA PF01155.19 AIF82861.1 - 0.056 13.5 0.4 0.058 13.4 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA OrfB_Zn_ribbon PF07282.11 AIF82861.1 - 0.064 13.2 1.4 0.086 12.8 1.4 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF2387 PF09526.10 AIF82861.1 - 0.065 13.4 2.0 3.3 7.9 0.1 2.2 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) Zn_Tnp_IS1595 PF12760.7 AIF82861.1 - 0.079 12.9 3.9 0.94 9.5 4.2 2.0 1 1 2 3 3 3 0 Transposase zinc-ribbon domain zf-Mss51 PF13824.6 AIF82861.1 - 0.1 12.7 1.3 1.5 9.0 1.3 2.1 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Ribosomal_S24e PF01282.19 AIF82862.1 - 9.7e-12 44.7 0.3 1.5e-11 44.1 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e UbiD PF01977.16 AIF82864.1 - 7.7e-154 512.4 0.6 8.8e-154 512.2 0.6 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DUF4751 PF15942.5 AIF82864.1 - 0.078 12.9 1.0 0.24 11.3 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4751) Acetyltransf_1 PF00583.25 AIF82865.1 - 9.4e-08 32.3 0.0 5e-07 30.0 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AIF82865.1 - 5.8e-07 29.8 0.0 1.2e-06 28.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AIF82865.1 - 3.5e-05 23.7 0.0 6.7e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AIF82865.1 - 0.093 12.8 0.0 1.5 8.9 0.0 2.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Radical_SAM PF04055.21 AIF82866.1 - 1.2e-18 68.1 0.1 2e-18 67.3 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Radical_SAM PF04055.21 AIF82867.1 - 4.2e-16 59.8 0.1 8.2e-16 58.8 0.1 1.5 1 0 0 1 1 1 1 Radical SAM superfamily DUF5460 PF17544.2 AIF82867.1 - 0.0022 17.1 0.0 0.0035 16.4 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5460) Halogen_Hydrol PF10112.9 AIF82868.1 - 0.043 13.8 1.5 0.043 13.8 1.5 1.0 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF5337 PF17272.2 AIF82868.1 - 0.2 11.5 5.7 0.14 12.1 2.7 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5337) Wzz PF02706.15 AIF82868.1 - 1.2 9.5 4.6 1.4 9.3 3.9 1.3 1 1 0 1 1 1 0 Chain length determinant protein FeoB_associated PF12669.7 AIF82868.1 - 2.6 8.5 6.9 1.2 9.6 0.1 2.1 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein DUF4407 PF14362.6 AIF82868.1 - 6.1 6.1 8.2 7.5 5.8 8.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4148 PF13663.6 AIF82868.1 - 7.4 6.8 9.0 3.6e+02 1.4 9.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4148) Amidase PF01425.21 AIF82869.1 - 3.4e-121 405.4 0.0 4e-121 405.1 0.0 1.1 1 0 0 1 1 1 1 Amidase Glyoxalase_2 PF12681.7 AIF82869.1 - 0.045 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Glyoxalase-like domain AIRC PF00731.20 AIF82870.1 - 1.6e-48 164.0 0.2 1.9e-48 163.8 0.2 1.0 1 0 0 1 1 1 1 AIR carboxylase Hydrolase_3 PF08282.12 AIF82870.1 - 0.12 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Transp_cyt_pur PF02133.15 AIF82871.1 - 1.1e-18 67.3 47.0 1.6e-18 66.8 47.0 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Isochorismatase PF00857.20 AIF82872.1 - 2.3e-31 109.3 0.0 4e-31 108.5 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family CitMHS PF03600.16 AIF82873.1 - 1.1e-53 182.4 37.3 1.1e-53 182.4 37.3 2.2 3 0 0 3 3 3 1 Citrate transporter ArsB PF02040.15 AIF82873.1 - 3e-16 59.8 33.9 4.2e-16 59.3 33.9 1.3 1 0 0 1 1 1 1 Arsenical pump membrane protein FAA_hydrolase PF01557.18 AIF82874.1 - 1.3e-68 231.0 0.0 2.4e-68 230.1 0.0 1.4 2 0 0 2 2 2 1 Fumarylacetoacetate (FAA) hydrolase family FliMN_C PF01052.20 AIF82874.1 - 0.022 14.8 0.1 0.05 13.6 0.1 1.7 1 1 0 1 1 1 0 Type III flagellar switch regulator (C-ring) FliN C-term VitK2_biosynth PF02621.14 AIF82877.1 - 2.6e-73 246.8 0.0 2.9e-73 246.7 0.0 1.0 1 0 0 1 1 1 1 Menaquinone biosynthesis GTP_EFTU PF00009.27 AIF82878.1 - 4.1e-54 183.1 0.0 6.8e-54 182.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 AIF82878.1 - 2.3e-20 72.6 0.2 2.6e-19 69.2 0.1 2.3 1 1 1 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 AIF82878.1 - 2.7e-19 69.0 0.0 5.9e-19 67.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 AIF82878.1 - 4e-19 68.5 0.3 7.6e-19 67.6 0.3 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 AIF82878.1 - 4e-11 43.1 0.0 1.2e-10 41.6 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AIF82878.1 - 0.0025 17.9 0.1 0.0071 16.4 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF3188 PF11384.8 AIF82879.1 - 1.1 9.0 6.4 2.7 7.8 0.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3188) SnoaL_2 PF12680.7 AIF82880.1 - 1.1e-09 38.8 0.0 1.3e-09 38.6 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIF82880.1 - 1e-07 32.3 0.0 1.1e-07 32.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL PF07366.12 AIF82880.1 - 0.00016 21.5 0.0 0.00018 21.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase DUF2700 PF10912.8 AIF82881.1 - 0.05 13.6 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2700) YbjM PF11045.8 AIF82881.1 - 0.073 13.2 0.1 0.19 11.9 0.0 1.6 2 0 0 2 2 2 0 Putative inner membrane protein of Enterobacteriaceae ABM PF03992.16 AIF82882.1 - 2.1e-07 30.9 0.1 3e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Fibin PF15819.5 AIF82882.1 - 0.02 14.6 0.1 0.023 14.5 0.1 1.1 1 0 0 1 1 1 0 Fin bud initiation factor homologue DUF1351 PF07083.11 AIF82886.1 - 0.0028 17.5 0.1 0.0042 16.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1351) Inhibitor_I67 PF11405.8 AIF82887.1 - 0.072 13.4 0.3 0.22 11.8 0.1 1.8 2 0 0 2 2 2 0 Bromelain inhibitor VI DUF3367 PF11847.8 AIF82889.1 - 0.066 11.1 1.1 0.091 10.6 1.1 1.2 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase adh_short PF00106.25 AIF82891.1 - 1.2e-47 161.9 1.4 3.5e-47 160.4 0.1 1.9 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIF82891.1 - 1.6e-36 126.0 0.2 2.7e-36 125.3 0.2 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIF82891.1 - 3.7e-09 36.7 1.1 1.2e-08 35.0 0.0 1.9 2 0 0 2 2 2 1 KR domain DUF1776 PF08643.10 AIF82891.1 - 0.00022 20.7 0.0 0.003 17.0 0.0 2.2 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) FTZ PF03867.14 AIF82892.1 - 0.11 12.0 0.4 0.12 11.9 0.4 1.1 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region Flg_new PF09479.10 AIF82894.1 - 0.049 13.8 0.4 0.12 12.6 0.1 1.9 2 0 0 2 2 2 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) PDDEXK_5 PF11645.8 AIF82896.1 - 0.0053 16.7 0.7 0.01 15.8 0.7 1.4 1 0 0 1 1 1 1 PD-(D/E)XK endonuclease PMSR PF01625.21 AIF82897.1 - 7.7e-66 221.0 3.0 8.9e-66 220.8 3.0 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase HTH_46 PF15977.5 AIF82898.1 - 0.0098 15.9 0.1 0.5 10.4 0.0 2.0 2 0 0 2 2 2 2 Winged helix-turn-helix DNA binding Rrf2 PF02082.20 AIF82898.1 - 0.08 13.3 0.0 0.084 13.2 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator HAD PF12710.7 AIF82899.1 - 3.8e-14 53.5 0.1 6.1e-14 52.8 0.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AIF82899.1 - 5.8e-10 39.3 0.5 2.9e-07 30.5 0.0 2.6 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AIF82899.1 - 7.5e-08 32.9 0.1 0.00026 21.3 0.0 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AIF82899.1 - 1.9e-05 24.8 0.7 1.7 8.7 0.0 3.2 2 1 0 3 3 3 3 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 AIF82899.1 - 3.4e-05 23.4 0.0 8.3e-05 22.1 0.0 1.7 1 1 0 1 1 1 1 Putative Phosphatase Hydrolase_like PF13242.6 AIF82899.1 - 0.0033 17.5 0.1 0.02 15.0 0.0 2.2 2 0 0 2 2 2 1 HAD-hyrolase-like Cyclotide PF03784.13 AIF82899.1 - 0.068 13.3 0.8 0.13 12.4 0.8 1.3 1 0 0 1 1 1 0 Cyclotide family MerT PF02411.15 AIF82900.1 - 0.018 15.1 3.1 0.018 15.1 3.1 2.5 2 1 0 2 2 2 0 MerT mercuric transport protein CytochromB561_N PF09786.9 AIF82900.1 - 0.13 11.2 0.1 0.21 10.5 0.1 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal DNase-RNase PF02577.14 AIF82901.1 - 1.2e-09 37.9 0.0 1.3e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Bifunctional nuclease DUF1297 PF06973.12 AIF82902.1 - 2.4e-75 252.2 0.2 3.3e-75 251.8 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) DUF1246 PF06849.12 AIF82902.1 - 5.4e-48 162.0 0.0 1.9e-47 160.3 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1246) MttA_Hcf106 PF02416.16 AIF82903.1 - 2.2e-10 39.7 0.5 1.5e-09 37.0 0.3 2.0 2 0 0 2 2 2 1 mttA/Hcf106 family DUF4834 PF16118.5 AIF82903.1 - 0.0095 16.9 0.1 0.012 16.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) OAD_gamma PF04277.13 AIF82903.1 - 0.029 14.9 0.1 0.046 14.3 0.1 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TatC PF00902.18 AIF82904.1 - 9.4e-48 162.8 18.8 1.1e-47 162.5 18.8 1.1 1 0 0 1 1 1 1 Sec-independent protein translocase protein (TatC) HEAT_2 PF13646.6 AIF82906.1 - 6.6e-23 80.9 1.0 4.1e-16 59.1 0.1 2.1 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 AIF82906.1 - 1.1e-11 44.0 0.3 0.11 12.8 0.1 4.2 4 0 0 4 4 4 3 HEAT repeat HEAT_PBS PF03130.16 AIF82906.1 - 4.8e-11 42.2 0.2 0.088 13.5 0.0 4.2 4 0 0 4 4 4 3 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 AIF82906.1 - 3.7e-06 27.3 2.4 0.53 10.9 0.1 4.0 2 2 2 4 4 4 2 HEAT-like repeat Cnd1 PF12717.7 AIF82906.1 - 4.3e-06 26.9 0.3 1.2 9.1 0.1 3.5 1 1 2 3 3 3 3 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 AIF82906.1 - 0.00089 19.2 0.3 23 5.2 0.1 3.9 3 1 1 4 4 4 0 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 AIF82906.1 - 0.019 14.3 0.1 0.022 14.0 0.1 1.3 1 1 0 1 1 1 0 V-ATPase subunit H DUF4042 PF13251.6 AIF82906.1 - 0.029 14.1 0.0 7.4 6.2 0.0 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4042) Adaptin_N PF01602.20 AIF82906.1 - 0.063 11.8 0.2 0.49 8.9 0.2 2.1 1 1 0 1 1 1 0 Adaptin N terminal region TPR_16 PF13432.6 AIF82906.1 - 0.2 12.4 0.6 24 5.7 0.3 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat Glyoxalase_6 PF18029.1 AIF82908.1 - 3.2e-05 24.7 0.0 4.5e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 AIF82908.1 - 0.014 15.6 0.0 0.2 11.9 0.0 2.0 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Methyltransf_4 PF02390.17 AIF82909.1 - 1e-06 28.3 0.0 2.3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase HD PF01966.22 AIF82909.1 - 1.4e-05 25.3 0.0 3.7e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 HD domain PDEase_I PF00233.19 AIF82909.1 - 0.00087 19.1 0.1 0.0019 18.0 0.1 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DRE2_N PF16803.5 AIF82909.1 - 0.18 12.0 0.1 0.47 10.7 0.0 1.7 2 0 0 2 2 2 0 Fe-S cluster assembly protein DRE2 N-terminus Nitroreductase PF00881.24 AIF82910.1 - 7.2e-26 91.3 0.1 1.5e-25 90.2 0.1 1.5 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 AIF82910.1 - 0.0037 16.9 0.6 0.41 10.2 0.1 2.7 2 1 1 3 3 3 2 Putative TM nitroreductase Complex1_LYR PF05347.15 AIF82910.1 - 0.045 13.8 3.4 0.98 9.5 0.0 2.3 2 0 0 2 2 2 0 Complex 1 protein (LYR family) N6_N4_Mtase PF01555.18 AIF82911.1 - 3e-47 161.3 0.0 2.2e-46 158.4 0.0 1.9 1 1 0 1 1 1 1 DNA methylase UPF0020 PF01170.18 AIF82911.1 - 0.00021 21.0 0.0 0.036 13.7 0.0 2.6 2 1 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 AIF82911.1 - 0.0067 17.1 0.0 0.088 13.5 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 AIF82911.1 - 0.011 15.2 0.0 0.66 9.5 0.0 2.8 2 1 0 2 2 2 0 Methyltransferase small domain Methyltransf_31 PF13847.6 AIF82911.1 - 0.02 14.7 0.0 0.058 13.2 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Cons_hypoth95 PF03602.15 AIF82911.1 - 0.1 12.3 0.0 0.35 10.5 0.0 1.8 2 0 0 2 2 2 0 Conserved hypothetical protein 95 zf-Di19 PF05605.12 AIF82912.1 - 0.048 14.0 0.1 0.08 13.3 0.1 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF4451 PF14616.6 AIF82912.1 - 0.083 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) Tom5 PF10642.9 AIF82912.1 - 0.18 11.9 0.9 0.29 11.2 0.9 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase zn-ribbon_14 PF16503.5 AIF82913.1 - 0.016 14.7 0.2 0.025 14.1 0.2 1.3 1 0 0 1 1 1 0 Zinc-ribbon FemAB_like PF04339.12 AIF82915.1 - 0.0031 16.7 1.6 0.0034 16.6 1.6 1.0 1 0 0 1 1 1 1 Peptidogalycan biosysnthesis/recognition PHP_C PF13263.6 AIF82918.1 - 6.2e-09 35.5 0.0 1.2e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 PHP-associated TFIIA_gamma_N PF02268.16 AIF82918.1 - 0.014 15.4 0.0 0.036 14.1 0.0 1.7 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit, helical domain TRAM PF01938.20 AIF82919.1 - 1.5e-13 50.5 2.9 1.7e-13 50.3 2.9 1.1 1 0 0 1 1 1 1 TRAM domain S1 PF00575.23 AIF82919.1 - 0.17 12.3 4.6 3.5 8.1 0.7 2.3 1 1 0 2 2 2 0 S1 RNA binding domain Isochorismatase PF00857.20 AIF82920.1 - 1.5e-41 142.5 0.0 1.8e-41 142.2 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family zf-AN1 PF01428.16 AIF82922.1 - 1.4e-10 41.1 6.6 2.1e-10 40.6 6.6 1.2 1 0 0 1 1 1 1 AN1-like Zinc finger Peptidase_M50 PF02163.22 AIF82922.1 - 0.0016 17.8 10.5 0.0043 16.4 1.0 2.5 1 1 1 2 2 2 2 Peptidase family M50 Transp_Tc5_C PF04236.15 AIF82922.1 - 0.31 11.4 3.6 0.48 10.8 3.6 1.3 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain DUF2024 PF09630.10 AIF82923.1 - 7.3e-10 38.6 0.5 3.4e-09 36.4 0.5 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF2024) Guanylate_cyc PF00211.20 AIF82926.1 - 6.3e-12 45.5 0.0 7.7e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Nrf1_DNA-bind PF10491.9 AIF82926.1 - 0.075 12.7 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Response_reg PF00072.24 AIF82927.1 - 9.8e-23 80.5 0.3 1.1e-22 80.3 0.3 1.0 1 0 0 1 1 1 1 Response regulator receiver domain BRCT_3 PF18428.1 AIF82927.1 - 0.12 12.4 0.0 0.28 11.3 0.0 1.5 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain HATPase_c PF02518.26 AIF82928.1 - 2.7e-27 95.5 0.0 6.2e-27 94.3 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 AIF82928.1 - 1e-15 57.8 0.1 6.8e-15 55.2 0.0 2.5 3 0 0 3 3 3 1 PAS domain HisKA PF00512.25 AIF82928.1 - 3.3e-15 55.9 0.4 1.6e-14 53.7 0.0 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain dCache_1 PF02743.18 AIF82928.1 - 1.1e-14 54.9 1.3 2.3e-13 50.5 0.5 2.7 3 0 0 3 3 3 1 Cache domain HAMP PF00672.25 AIF82928.1 - 2.5e-14 53.4 0.0 7.1e-14 51.9 0.0 1.9 1 0 0 1 1 1 1 HAMP domain PAS_3 PF08447.12 AIF82928.1 - 4.6e-13 49.3 0.1 9.8e-13 48.2 0.1 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 AIF82928.1 - 5.1e-12 45.8 0.0 1.6e-11 44.2 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 AIF82928.1 - 2.8e-09 37.2 0.0 6.5e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 AIF82928.1 - 0.0056 16.7 0.0 0.02 14.9 0.0 1.9 1 0 0 1 1 1 1 PAS domain AA_permease_2 PF13520.6 AIF82929.1 - 1.5e-36 126.2 47.3 2.1e-36 125.7 47.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AIF82929.1 - 2.3e-32 112.2 42.1 3.2e-32 111.8 42.1 1.1 1 0 0 1 1 1 1 Amino acid permease Usp PF00582.26 AIF82929.1 - 1.1e-05 26.0 1.0 0.13 12.8 0.4 3.4 2 1 0 2 2 2 2 Universal stress protein family AA_permease_C PF13906.6 AIF82929.1 - 1.3e-05 25.1 6.6 1.3e-05 25.1 6.6 3.0 2 0 0 2 2 2 1 C-terminus of AA_permease CLP1_P PF16575.5 AIF82930.1 - 2.8e-25 89.2 0.0 4.4e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop QueC PF06508.13 AIF82931.1 - 3.4e-46 157.4 0.0 3.8e-46 157.2 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 AIF82931.1 - 1.7e-06 27.8 0.0 1.6e-05 24.5 0.0 2.3 1 1 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Diphthami_syn_2 PF01902.17 AIF82931.1 - 0.0051 16.4 0.0 0.011 15.2 0.0 1.6 1 1 0 1 1 1 1 Diphthamide synthase NAD_synthase PF02540.17 AIF82931.1 - 0.0054 15.9 0.0 0.063 12.4 0.0 2.0 2 0 0 2 2 2 1 NAD synthase ATP_bind_3 PF01171.20 AIF82931.1 - 0.008 16.0 0.0 0.014 15.1 0.0 1.5 1 1 0 1 1 1 1 PP-loop family Asn_synthase PF00733.21 AIF82931.1 - 0.022 14.4 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase PTPS PF01242.19 AIF82932.1 - 3.4e-18 65.8 0.0 7.1e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase DUF4494 PF14902.6 AIF82933.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4494) Asn_synthase PF00733.21 AIF82934.1 - 1.6e-32 113.6 0.3 1.1e-19 71.3 0.1 2.0 1 1 1 2 2 2 2 Asparagine synthase NAD_synthase PF02540.17 AIF82934.1 - 2.4e-07 30.2 0.0 3.7e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 AIF82934.1 - 2e-06 27.5 0.0 2.9e-06 26.9 0.0 1.4 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 AIF82934.1 - 0.00037 19.4 0.1 0.0009 18.1 0.1 1.6 1 1 0 1 1 1 1 tRNA methyl transferase ATP_bind_3 PF01171.20 AIF82934.1 - 0.0035 17.1 0.1 0.011 15.6 0.1 1.9 2 1 0 2 2 2 1 PP-loop family HTH_45 PF14947.6 AIF82935.1 - 0.0074 16.2 0.9 0.0094 15.9 0.2 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix Sulfolobus_pRN PF05584.11 AIF82935.1 - 0.039 14.0 0.1 0.063 13.3 0.1 1.3 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein Rio2_N PF09202.11 AIF82935.1 - 0.058 13.6 0.1 0.19 11.9 0.0 1.8 2 0 0 2 2 2 0 Rio2, N-terminal DUF4209 PF13910.6 AIF82935.1 - 0.13 12.5 0.0 12 6.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4209) UbiA PF01040.18 AIF82936.1 - 3.6e-32 111.6 15.9 4.6e-32 111.3 15.5 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family Lig_chan PF00060.26 AIF82936.1 - 1.2 8.9 4.7 9 6.1 0.0 2.4 2 0 0 2 2 2 0 Ligand-gated ion channel FA_desaturase PF00487.24 AIF82936.1 - 7.4 6.3 10.0 6.5 6.5 0.7 3.0 1 1 2 3 3 3 0 Fatty acid desaturase PRA1 PF03208.19 AIF82936.1 - 8.6 6.0 17.0 0.33 10.6 1.2 3.0 3 1 1 4 4 4 0 PRA1 family protein HTH_45 PF14947.6 AIF82937.1 - 0.00059 19.8 0.3 0.0013 18.7 0.3 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_20 PF12840.7 AIF82937.1 - 0.0058 16.7 0.0 0.024 14.7 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.6 AIF82937.1 - 0.052 13.1 0.2 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding B-block_TFIIIC PF04182.12 AIF82937.1 - 0.081 13.1 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC Hydrolase_4 PF12146.8 AIF82938.1 - 1.4e-32 112.9 0.0 1.8e-32 112.5 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AIF82938.1 - 3.5e-20 72.7 0.1 1.6e-17 64.0 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIF82938.1 - 8.2e-18 65.8 0.0 1e-17 65.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 AIF82938.1 - 1.1e-06 28.4 0.4 4.9e-06 26.3 0.4 1.8 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 AIF82938.1 - 3.4e-06 26.7 0.0 0.00017 21.1 0.0 2.3 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 AIF82938.1 - 6e-05 22.7 0.0 0.065 12.8 0.0 2.9 2 1 0 2 2 2 2 Dienelactone hydrolase family FSH1 PF03959.13 AIF82938.1 - 9.6e-05 22.1 0.1 0.17 11.5 0.1 3.0 2 1 0 2 2 2 2 Serine hydrolase (FSH1) DUF1057 PF06342.12 AIF82938.1 - 0.00024 20.2 0.0 0.00042 19.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) DUF1749 PF08538.10 AIF82938.1 - 0.00039 19.6 0.0 0.00095 18.3 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) Annexin PF00191.20 AIF82938.1 - 0.0047 17.0 0.0 0.018 15.1 0.0 2.0 2 0 0 2 2 2 1 Annexin BAAT_C PF08840.11 AIF82938.1 - 0.0071 16.3 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_5 PF12695.7 AIF82938.1 - 0.034 13.9 0.0 0.92 9.3 0.0 2.4 2 1 0 2 2 2 0 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 AIF82938.1 - 0.037 13.6 0.0 7.9 6.0 0.0 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 AIF82938.1 - 0.053 13.4 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 AIF82938.1 - 0.061 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase LCAT PF02450.15 AIF82938.1 - 0.086 12.0 0.3 0.31 10.2 0.0 1.8 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase Asp2 PF16929.5 AIF82938.1 - 0.092 11.7 0.0 0.13 11.2 0.0 1.4 1 1 0 1 1 1 0 Accessory Sec system GspB-transporter PGAP1 PF07819.13 AIF82938.1 - 0.093 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Methyltransf_31 PF13847.6 AIF82939.1 - 1.4e-18 67.1 0.0 1.9e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF82939.1 - 3.2e-16 59.7 0.1 5.2e-16 59.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF82939.1 - 3.5e-16 59.7 0.1 8.2e-16 58.5 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF82939.1 - 2.7e-12 46.8 0.0 3.7e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF82939.1 - 1.5e-09 38.5 0.0 2.7e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF82939.1 - 2.3e-09 36.9 0.0 3.2e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 AIF82939.1 - 1e-05 25.7 0.2 2.5e-05 24.5 0.2 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 AIF82939.1 - 2e-05 24.5 0.0 3.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 AIF82939.1 - 3.2e-05 23.0 0.0 5e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 AIF82939.1 - 0.00014 21.2 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 AIF82939.1 - 0.0002 22.4 0.0 0.0003 21.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AIF82939.1 - 0.0052 16.3 0.0 0.008 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain GidB PF02527.15 AIF82939.1 - 0.0053 16.1 0.0 0.0099 15.2 0.0 1.4 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G GCD14 PF08704.10 AIF82939.1 - 0.0082 15.8 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit DUF4545 PF15078.6 AIF82939.1 - 0.021 13.8 0.2 0.2 10.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4545) CheR PF01739.18 AIF82939.1 - 0.046 13.2 0.1 0.45 10.0 0.1 2.0 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_32 PF13679.6 AIF82939.1 - 0.056 13.4 0.0 0.082 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 AIF82939.1 - 0.088 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PAS_3 PF08447.12 AIF82939.1 - 0.14 12.5 0.1 5.8 7.3 0.0 2.9 2 1 1 3 3 3 0 PAS fold MTBP_N PF14918.6 AIF82940.1 - 0.082 12.4 0.0 0.09 12.2 0.0 1.0 1 0 0 1 1 1 0 MDM2-binding PHO4 PF01384.20 AIF82941.1 - 4.8e-86 288.9 36.9 1.7e-85 287.1 36.9 1.7 1 1 0 1 1 1 1 Phosphate transporter family Keratin_assoc PF09775.9 AIF82941.1 - 8.5 6.1 8.5 2.2 7.9 0.5 3.4 3 1 0 3 3 3 0 Keratinocyte-associated protein 2 PhoU_div PF01865.16 AIF82942.1 - 4.5e-27 94.8 6.3 5.3e-27 94.6 6.3 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 PMC2NT PF08066.12 AIF82942.1 - 0.063 14.0 3.8 0.11 13.2 1.1 2.6 2 2 0 2 2 2 0 PMC2NT (NUC016) domain zf-C2H2 PF00096.26 AIF82943.1 - 0.002 18.5 1.2 0.0058 17.0 0.6 2.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF82943.1 - 0.0031 18.2 1.6 0.012 16.4 0.6 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AIF82943.1 - 0.0041 17.4 0.9 0.038 14.3 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding HicB-like_2 PF15970.5 AIF82944.1 - 0.14 12.3 0.1 0.2 11.8 0.1 1.2 1 0 0 1 1 1 0 HicB_like antitoxin of bacterial toxin-antitoxin system Defensin_beta_2 PF13841.6 AIF82944.1 - 0.15 12.6 3.9 0.46 11.0 0.1 2.4 2 1 0 2 2 2 0 Beta defensin T6SS_HCP PF05638.12 AIF82945.1 - 7.7e-41 139.5 0.2 1.1e-40 139.1 0.2 1.2 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp SSURE PF11966.8 AIF82945.1 - 0.022 14.5 0.1 0.051 13.3 0.1 1.6 1 1 0 1 1 1 0 Fibronectin-binding repeat DUF4307 PF14155.6 AIF82945.1 - 0.14 12.0 1.0 1.2 9.0 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) DUF72 PF01904.18 AIF82947.1 - 5.3e-61 206.5 0.3 6.2e-61 206.3 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 NOGCT PF08155.11 AIF82949.1 - 0.061 13.3 0.2 0.15 12.0 0.2 1.7 1 1 0 1 1 1 0 NOGCT (NUC087) domain DUF5475 PF17569.2 AIF82951.1 - 0.095 13.0 0.0 0.18 12.1 0.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5475) HxlR PF01638.17 AIF82952.1 - 0.0095 15.8 0.0 0.0095 15.8 0.0 1.3 1 1 0 1 1 1 1 HxlR-like helix-turn-helix Sec34 PF04136.15 AIF82953.1 - 0.18 11.7 2.6 1.2 9.0 0.6 2.5 2 0 0 2 2 2 0 Sec34-like family DUF1993 PF09351.10 AIF82953.1 - 0.43 10.7 2.7 11 6.2 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1993) Phage_Nu1 PF07471.12 AIF82953.1 - 2.1 8.1 6.0 0.72 9.6 0.6 2.6 3 0 0 3 3 3 0 Phage DNA packaging protein Nu1 DUF1351 PF07083.11 AIF82953.1 - 3.4 7.4 10.9 1 9.1 5.3 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1351) CENP-H PF05837.12 AIF82953.1 - 7.6 7.0 7.8 1.2 9.6 0.2 2.9 3 0 0 3 3 3 0 Centromere protein H (CENP-H) Thioredoxin PF00085.20 AIF82954.1 - 7.9e-26 90.1 0.0 9.6e-26 89.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AIF82954.1 - 1.6e-05 25.3 0.0 0.00053 20.4 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 AIF82954.1 - 6.7e-05 22.7 0.0 8.2e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 AIF82954.1 - 0.00011 21.6 0.0 0.00015 21.2 0.0 1.3 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 AIF82954.1 - 0.00016 21.8 0.0 0.00023 21.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.6 AIF82954.1 - 0.0024 18.2 0.0 0.21 11.9 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_3 PF13192.6 AIF82954.1 - 0.0044 17.0 0.0 0.0061 16.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain TraF PF13728.6 AIF82954.1 - 0.034 14.0 0.0 0.038 13.8 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein HyaE PF07449.11 AIF82954.1 - 0.091 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE TrmB PF01978.19 AIF82955.1 - 1e-08 34.9 0.1 9.7e-08 31.8 0.0 1.9 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 AIF82955.1 - 5.1e-06 26.3 0.2 1.7e-05 24.6 0.0 1.8 2 0 0 2 2 2 1 MarR family HTH_IclR PF09339.10 AIF82955.1 - 8.3e-06 25.5 0.4 1.5e-05 24.7 0.4 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain MarR_2 PF12802.7 AIF82955.1 - 8.1e-05 22.4 0.2 0.00017 21.4 0.1 1.5 2 0 0 2 2 2 1 MarR family Nbl1_Borealin_N PF10444.9 AIF82955.1 - 0.0012 18.4 0.3 0.0022 17.6 0.3 1.4 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal HTH_24 PF13412.6 AIF82955.1 - 0.0067 16.0 0.4 0.028 14.0 0.0 2.1 2 1 1 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 AIF82955.1 - 0.0076 16.2 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 HTH domain DUF883 PF05957.13 AIF82955.1 - 0.02 15.4 1.0 0.036 14.7 0.2 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) HrcA_DNA-bdg PF03444.15 AIF82955.1 - 0.037 13.7 0.0 0.068 12.8 0.0 1.5 1 1 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HTH_29 PF13551.6 AIF82955.1 - 0.058 13.4 0.0 0.17 11.9 0.0 1.9 1 1 1 2 2 2 0 Winged helix-turn helix Phage_holin_3_6 PF07332.11 AIF82956.1 - 0.0029 17.6 4.1 0.0029 17.6 4.1 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III DUF4501 PF14946.6 AIF82956.1 - 0.013 15.6 0.1 0.014 15.5 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) Usp PF00582.26 AIF82957.1 - 3.3e-29 102.2 0.0 4e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Flavodoxin_5 PF12724.7 AIF82958.1 - 1.6e-06 28.4 0.0 4e-06 27.1 0.0 1.6 2 0 0 2 2 2 1 Flavodoxin domain Flavodoxin_1 PF00258.25 AIF82958.1 - 2e-06 28.0 0.0 3.5e-06 27.3 0.0 1.6 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_3 PF12641.7 AIF82958.1 - 1.8e-05 24.5 0.0 2.3e-05 24.1 0.0 1.4 1 1 0 1 1 1 1 Flavodoxin domain FMN_red PF03358.15 AIF82958.1 - 0.12 12.1 0.0 0.74 9.6 0.0 1.9 1 1 1 2 2 2 0 NADPH-dependent FMN reductase DUF4232 PF14016.6 AIF82959.1 - 0.11 12.6 0.1 0.43 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4232) Saf_2TM PF18303.1 AIF82959.1 - 0.2 11.2 3.7 0.45 10.1 1.0 2.5 2 1 0 2 2 2 0 SAVED-fused 2TM effector domain RDD PF06271.12 AIF82960.1 - 4e-11 43.3 8.0 2.5e-10 40.7 8.0 2.0 1 1 0 1 1 1 1 RDD family PqqD PF05402.12 AIF82961.1 - 0.0059 16.9 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) DUF3143 PF11341.8 AIF82961.1 - 0.091 13.1 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3143) DUF1773 PF08593.10 AIF82961.1 - 0.15 13.2 0.0 0.38 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function Mic1 PF07035.12 AIF82962.1 - 0.088 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Colon cancer-associated protein Mic1-like DUF998 PF06197.13 AIF82963.1 - 0.7 9.5 13.4 0.85 9.2 13.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF998) Usp PF00582.26 AIF82964.1 - 6.7e-27 94.7 1.7 1.9e-25 90.0 1.7 2.6 1 1 0 1 1 1 1 Universal stress protein family RNA_Me_trans PF04252.13 AIF82964.1 - 0.0024 17.5 0.0 0.0029 17.2 0.0 1.1 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase ADH_zinc_N PF00107.26 AIF82965.1 - 1.7e-28 99.2 0.2 2.8e-28 98.5 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AIF82965.1 - 7e-26 90.2 0.2 1.3e-25 89.4 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 AIF82965.1 - 3e-17 63.9 0.0 6.7e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AIF82965.1 - 5.3e-05 22.8 0.2 7.4e-05 22.3 0.2 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Methyltransf_31 PF13847.6 AIF82965.1 - 0.044 13.6 0.1 0.23 11.3 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain TrkA_N PF02254.18 AIF82965.1 - 0.055 13.7 0.3 0.096 12.9 0.3 1.4 1 0 0 1 1 1 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 AIF82965.1 - 0.09 13.0 0.2 0.17 12.2 0.2 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain CBS PF00571.28 AIF82966.1 - 4e-15 56.0 0.1 0.0015 18.9 0.0 3.4 3 0 0 3 3 3 3 CBS domain HTH_23 PF13384.6 AIF82967.1 - 0.0001 21.9 0.0 0.00013 21.7 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_ECF PF07638.11 AIF82967.1 - 0.00063 19.7 0.1 0.00063 19.7 0.1 1.0 1 0 0 1 1 1 1 ECF sigma factor Sigma70_r4_2 PF08281.12 AIF82967.1 - 0.0014 18.2 0.1 0.0018 17.9 0.1 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_7 PF02796.15 AIF82967.1 - 0.0015 18.6 0.1 0.0018 18.3 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase Sigma70_r4 PF04545.16 AIF82967.1 - 0.011 15.3 0.3 0.012 15.1 0.3 1.1 1 0 0 1 1 1 0 Sigma-70, region 4 GerE PF00196.19 AIF82967.1 - 0.018 14.5 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_29 PF13551.6 AIF82967.1 - 0.02 14.9 0.0 0.024 14.7 0.0 1.1 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 AIF82967.1 - 0.023 14.1 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_38 PF13936.6 AIF82967.1 - 0.048 13.4 0.2 0.076 12.8 0.1 1.4 1 1 0 1 1 1 0 Helix-turn-helix domain GcrA PF07750.11 AIF82967.1 - 0.12 12.8 0.0 0.13 12.7 0.0 1.1 1 0 0 1 1 1 0 GcrA cell cycle regulator AA_permease_2 PF13520.6 AIF82968.1 - 7.1e-55 186.5 52.3 8.1e-55 186.3 52.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AIF82968.1 - 4.7e-38 131.0 48.7 5.7e-38 130.7 48.7 1.0 1 0 0 1 1 1 1 Amino acid permease Spore_permease PF03845.13 AIF82968.1 - 0.064 12.1 28.3 0.38 9.5 18.3 2.9 2 1 0 2 2 2 0 Spore germination protein Usp PF00582.26 AIF82969.1 - 3.5e-34 118.3 0.1 4.5e-34 118.0 0.1 1.0 1 0 0 1 1 1 1 Universal stress protein family TPR_16 PF13432.6 AIF82969.1 - 0.3 11.8 1.8 0.36 11.5 0.8 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat CBS PF00571.28 AIF82970.1 - 5.3e-29 100.4 4.4 4.5e-16 59.0 0.2 2.1 2 0 0 2 2 2 2 CBS domain ChapFlgA PF13144.6 AIF82970.1 - 0.022 14.8 1.4 0.036 14.1 0.7 1.7 1 1 1 2 2 2 0 Chaperone for flagella basal body P-ring formation IF3_N PF05198.16 AIF82970.1 - 0.037 14.3 1.3 4.4 7.7 0.3 3.2 1 1 1 2 2 2 0 Translation initiation factor IF-3, N-terminal domain CBS PF00571.28 AIF82971.1 - 3.8e-19 68.9 2.9 1.3e-09 38.4 0.3 2.2 2 0 0 2 2 2 2 CBS domain zf-C2H2_4 PF13894.6 AIF82971.1 - 0.00024 21.7 0.1 0.0004 21.0 0.1 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF82971.1 - 0.0019 18.6 0.1 0.0029 18.0 0.1 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-Di19 PF05605.12 AIF82971.1 - 0.0025 18.1 0.0 0.0038 17.5 0.0 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 AIF82971.1 - 0.027 14.7 0.0 0.044 14.1 0.0 1.3 1 0 0 1 1 1 0 zinc-ribbon Coiled PF05710.12 AIF82971.1 - 0.05 14.4 0.5 0.05 14.4 0.5 1.8 2 0 0 2 2 2 0 Coiled coil zf-C2H2_9 PF16293.5 AIF82971.1 - 0.054 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) Cys_rich_CPXG PF14255.6 AIF82971.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Cysteine-rich CPXCG Usp PF00582.26 AIF82972.1 - 1.4e-27 96.9 0.5 1.6e-27 96.7 0.5 1.1 1 0 0 1 1 1 1 Universal stress protein family Peripla_BP_4 PF13407.6 AIF82972.1 - 0.027 14.1 0.0 0.041 13.4 0.0 1.2 1 1 0 1 1 1 0 Periplasmic binding protein domain CopG_antitoxin PF12441.8 AIF82973.1 - 0.00055 20.4 0.1 0.0027 18.2 0.0 2.1 2 0 0 2 2 2 1 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIF82973.1 - 0.15 11.9 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 HicB family SnoaL_2 PF12680.7 AIF82974.1 - 0.00018 22.1 0.0 0.00022 21.8 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain NTF2 PF02136.20 AIF82974.1 - 0.029 14.9 0.0 0.037 14.6 0.0 1.2 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain SnoaL_4 PF13577.6 AIF82974.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.5 1 1 0 1 1 1 0 SnoaL-like domain DUF4440 PF14534.6 AIF82974.1 - 0.19 12.1 0.0 0.27 11.7 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) CBS PF00571.28 AIF82976.1 - 9.1e-24 83.7 4.0 8.9e-12 45.3 0.0 2.2 2 0 0 2 2 2 2 CBS domain P-II PF00543.22 AIF82977.1 - 0.0005 20.6 0.0 0.00054 20.5 0.0 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II Cu-oxidase_3 PF07732.15 AIF82978.1 - 9.5e-25 86.9 5.8 1e-24 86.8 1.0 2.8 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 AIF82978.1 - 3.2e-19 69.0 7.6 1e-07 31.8 3.8 3.7 2 1 0 2 2 2 2 Multicopper oxidase Cupredoxin_1 PF13473.6 AIF82978.1 - 4.6e-10 39.5 0.1 0.00016 21.8 0.0 3.9 4 0 0 4 4 4 2 Cupredoxin-like domain Copper-bind PF00127.20 AIF82978.1 - 1.1e-07 32.2 7.4 0.0011 19.4 1.3 3.8 3 2 0 3 3 3 2 Copper binding proteins, plastocyanin/azurin family COX1 PF00115.20 AIF82979.1 - 3.2e-05 23.0 12.1 3.2e-05 23.0 12.1 2.1 1 1 1 2 2 2 1 Cytochrome C and Quinol oxidase polypeptide I eIF2_C PF09173.11 AIF82979.1 - 0.043 14.1 0.0 0.11 12.7 0.0 1.6 2 0 0 2 2 2 0 Initiation factor eIF2 gamma, C terminal DUF4386 PF14329.6 AIF82979.1 - 0.13 12.1 12.7 0.036 14.0 7.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4386) DUF4271 PF14093.6 AIF82979.1 - 0.19 11.6 3.8 0.049 13.5 0.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) DUF2207 PF09972.9 AIF82979.1 - 1.8 7.2 14.8 0.081 11.7 5.9 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) VIT1 PF01988.19 AIF82981.1 - 7.9e-60 202.4 3.2 8.9e-60 202.2 3.2 1.0 1 0 0 1 1 1 1 VIT family DUF123 PF01986.16 AIF82981.1 - 0.051 14.1 0.1 0.079 13.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF123 Usp PF00582.26 AIF82983.1 - 1.8e-31 109.6 0.0 2e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family YtxH PF12732.7 AIF82983.1 - 0.026 15.1 1.2 0.056 14.0 1.2 1.5 1 0 0 1 1 1 0 YtxH-like protein Cupredoxin_1 PF13473.6 AIF82984.1 - 0.0014 18.7 0.0 0.0029 17.7 0.0 1.6 1 1 0 1 1 1 1 Cupredoxin-like domain Kin17_mid PF10357.9 AIF82985.1 - 0.0039 17.1 0.1 0.0082 16.1 0.1 1.5 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein NETI PF14044.6 AIF82985.1 - 0.12 12.2 0.1 4.8 7.0 0.1 2.4 2 0 0 2 2 2 0 NETI protein DUF2162 PF09930.9 AIF82987.1 - 0.0052 16.2 1.6 0.006 16.0 1.6 1.1 1 0 0 1 1 1 1 Predicted transporter (DUF2162) DUF2142 PF09913.9 AIF82987.1 - 0.029 13.2 5.5 0.036 12.9 5.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) EXS PF03124.14 AIF82987.1 - 0.03 13.7 2.5 0.031 13.6 2.5 1.0 1 0 0 1 1 1 0 EXS family DUF3681 PF12442.8 AIF82987.1 - 0.032 14.7 1.2 0.039 14.4 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3681) DUF3624 PF12292.8 AIF82987.1 - 0.057 13.8 2.8 0.074 13.5 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3624) DUF2157 PF09925.9 AIF82987.1 - 0.49 10.2 6.7 0.6 9.9 6.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) MgtE PF01769.16 AIF82987.1 - 0.57 10.6 6.2 0.69 10.3 6.2 1.0 1 0 0 1 1 1 0 Divalent cation transporter DUF2427 PF10348.9 AIF82987.1 - 0.78 9.6 5.7 0.9 9.4 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) Phage_holin_3_6 PF07332.11 AIF82987.1 - 0.99 9.5 4.4 1.1 9.3 4.4 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2207 PF09972.9 AIF82987.1 - 1.1 7.9 5.5 1.2 7.8 5.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Flavi_NS4A PF01350.17 AIF82989.1 - 0.079 12.9 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A ResIII PF04851.15 AIF82990.1 - 2.6e-16 60.1 0.2 1.4e-15 57.7 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AIF82990.1 - 6.3e-16 58.7 0.2 1.6e-15 57.4 0.2 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 AIF82990.1 - 1.2e-09 37.7 1.0 2.1e-09 36.9 1.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 AIF82990.1 - 1.4e-08 34.7 0.1 2.9e-07 30.4 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_30 PF13604.6 AIF82990.1 - 0.0059 16.4 0.0 0.052 13.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain DNA_pol3_chi PF04364.13 AIF82990.1 - 0.014 15.6 0.7 2.2 8.4 0.2 2.6 2 1 0 2 2 2 0 DNA polymerase III chi subunit, HolC DUF2075 PF09848.9 AIF82990.1 - 0.017 14.4 0.7 0.08 12.2 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) CdhD PF03599.16 AIF82990.1 - 0.059 12.1 0.3 0.12 11.1 0.3 1.4 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit Rsm22 PF09243.10 AIF82990.1 - 0.12 11.7 0.1 0.19 10.9 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 SIS_2 PF13580.6 AIF82990.1 - 0.16 12.0 0.0 9 6.3 0.0 2.4 2 0 0 2 2 2 0 SIS domain TP_methylase PF00590.20 AIF82992.1 - 3e-35 122.1 0.1 3.6e-35 121.8 0.1 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases PepSY PF03413.19 AIF82994.1 - 0.0026 18.3 0.2 0.0051 17.4 0.2 1.5 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain DUF2090 PF09863.9 AIF82994.1 - 0.26 10.3 0.0 0.39 9.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2090) DUF4244 PF14029.6 AIF82995.1 - 0.007 15.8 0.1 0.0084 15.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4244) DUF2795 PF11387.8 AIF82996.1 - 4e-08 33.3 0.1 6.9e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2795) zf-C2H2_4 PF13894.6 AIF82996.1 - 0.00017 22.2 0.1 0.00027 21.5 0.1 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 AIF82996.1 - 0.00021 22.0 1.8 0.018 15.7 0.1 1.5 1 1 1 2 2 2 2 Zinc finger C2H2-type, 3 repeats zf-C2H2 PF00096.26 AIF82996.1 - 0.01 16.3 0.1 0.016 15.6 0.1 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 AIF82996.1 - 0.014 15.4 0.0 0.018 15.0 0.0 1.2 1 0 0 1 1 1 0 C2H2-type zinc finger zf-Di19 PF05605.12 AIF82996.1 - 0.066 13.5 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_12 PF18658.1 AIF82996.1 - 0.098 12.2 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger C2H2-type zf-C2H2_2 PF12756.7 AIF82996.1 - 0.1 12.9 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF3088 PF11287.8 AIF82996.1 - 0.23 11.2 0.8 1 9.1 0.8 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3088) DUF4367 PF14285.6 AIF82997.1 - 0.0013 19.1 0.9 0.0056 17.1 0.0 2.2 1 1 0 2 2 2 1 Domain of unknown function (DUF4367) PCuAC PF04314.13 AIF82997.1 - 0.01 15.7 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Copper chaperone PCu(A)C ATP19 PF11022.8 AIF82997.1 - 0.095 13.1 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 ATP synthase subunit K Phage_integr_3 PF16795.5 AIF82998.1 - 4.5e-06 26.7 0.0 4.5e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Archaeal phage integrase PepSY PF03413.19 AIF83001.1 - 2.7e-09 37.4 0.5 0.00056 20.4 0.0 2.5 2 1 0 2 2 2 2 Peptidase propeptide and YPEB domain Glyco_hydro_65N PF03636.15 AIF83001.1 - 0.048 13.3 0.2 0.37 10.4 0.0 2.0 2 0 0 2 2 2 0 Glycosyl hydrolase family 65, N-terminal domain dTDP_sugar_isom PF00908.17 AIF83001.1 - 0.092 12.4 0.0 2 8.1 0.0 2.4 2 0 0 2 2 2 0 dTDP-4-dehydrorhamnose 3,5-epimerase Transposase_31 PF04754.12 AIF83001.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.1 1 0 0 1 1 1 0 Putative transposase, YhgA-like AP2 PF00847.20 AIF83001.1 - 0.19 12.0 0.0 0.33 11.2 0.0 1.3 1 0 0 1 1 1 0 AP2 domain GRIM-19 PF06212.12 AIF83002.1 - 0.0064 16.4 0.0 0.0096 15.9 0.0 1.2 1 0 0 1 1 1 1 GRIM-19 protein NPR1_like_C PF12313.8 AIF83002.1 - 0.13 11.8 0.6 0.16 11.4 0.6 1.1 1 0 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal HTH_45 PF14947.6 AIF83003.1 - 2.8e-07 30.4 0.8 3.8e-07 30.0 0.8 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIF83003.1 - 7.5e-06 25.8 0.0 1.1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIF83003.1 - 0.0012 18.7 0.0 0.0015 18.4 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HxlR PF01638.17 AIF83003.1 - 0.073 12.9 0.0 0.091 12.6 0.0 1.2 1 0 0 1 1 1 0 HxlR-like helix-turn-helix 7TM-7TMR_HD PF07698.11 AIF83004.1 - 0.033 13.9 7.4 0.043 13.6 7.4 1.2 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF4282 PF14110.6 AIF83004.1 - 9.5 7.0 11.4 1.4 9.7 2.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) ABC_tran PF00005.27 AIF83005.1 - 8.6e-36 123.5 0.0 1.2e-35 123.0 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AIF83005.1 - 1.4e-07 31.2 0.9 0.0034 16.9 0.1 2.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 AIF83005.1 - 7.5e-07 29.2 1.6 0.014 15.2 0.8 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 AIF83005.1 - 1.2e-05 25.3 0.2 4.9e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 AIF83005.1 - 4.5e-05 23.1 0.1 8.5e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 AIF83005.1 - 0.00031 21.0 0.2 0.0017 18.6 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIF83005.1 - 0.00052 20.4 0.0 0.00063 20.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 AIF83005.1 - 0.00054 19.8 0.1 0.17 11.5 0.0 2.1 1 1 0 2 2 2 1 AAA ATPase domain cobW PF02492.19 AIF83005.1 - 0.0012 18.4 0.0 0.0023 17.5 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.17 AIF83005.1 - 0.0026 17.5 0.0 0.12 12.1 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_23 PF13476.6 AIF83005.1 - 0.0029 18.2 0.1 0.0058 17.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AIF83005.1 - 0.0046 17.1 0.7 0.06 13.5 0.7 2.2 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 AIF83005.1 - 0.0063 16.6 0.5 0.015 15.3 0.5 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 AIF83005.1 - 0.0081 15.6 0.3 0.61 9.5 0.2 2.2 2 0 0 2 2 2 1 Bacterial TniB protein G-alpha PF00503.20 AIF83005.1 - 0.0098 15.1 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_30 PF13604.6 AIF83005.1 - 0.01 15.6 0.1 0.022 14.5 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AIF83005.1 - 0.013 15.0 0.3 0.11 12.0 0.1 2.2 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 AIF83005.1 - 0.027 15.0 0.5 0.12 12.9 0.1 2.1 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.6 AIF83005.1 - 0.028 14.7 0.0 0.055 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Tk-SP_N-pro PF18237.1 AIF83005.1 - 0.039 14.0 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 Tk-SP N-propeptide domain Rad17 PF03215.15 AIF83005.1 - 0.082 12.8 0.0 0.21 11.5 0.0 1.6 1 1 0 1 1 1 0 Rad17 P-loop domain DIM PF08194.12 AIF83005.1 - 0.11 12.7 0.4 0.31 11.3 0.1 1.9 2 0 0 2 2 2 0 DIM protein Dynamin_N PF00350.23 AIF83005.1 - 0.12 12.4 0.2 0.3 11.1 0.2 1.6 1 0 0 1 1 1 0 Dynamin family AAA_24 PF13479.6 AIF83005.1 - 0.13 12.0 0.1 0.3 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 AIF83005.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AIF83005.1 - 0.16 11.9 0.0 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain NPCBM_assoc PF10633.9 AIF83006.1 - 3.3e-06 27.2 6.9 0.0075 16.5 0.1 4.6 5 0 0 5 5 5 2 NPCBM-associated, NEW3 domain of alpha-galactosidase LapA_dom PF06305.11 AIF83006.1 - 0.098 12.5 0.8 0.23 11.3 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain YscW PF09619.10 AIF83006.1 - 0.11 12.9 0.0 0.43 11.0 0.0 2.0 2 0 0 2 2 2 0 Type III secretion system lipoprotein chaperone (YscW) CARDB PF07705.11 AIF83006.1 - 0.12 12.7 16.1 0.3 11.4 0.5 4.7 4 1 0 4 4 4 0 CARDB FtsX PF02687.21 AIF83007.1 - 6.4e-13 49.0 1.5 6.4e-13 49.0 1.5 3.2 3 0 0 3 3 3 2 FtsX-like permease family MacB_PCD PF12704.7 AIF83007.1 - 5e-12 46.6 5.7 5e-12 46.6 5.7 2.6 2 1 0 3 3 3 1 MacB-like periplasmic core domain AA_kinase PF00696.28 AIF83009.1 - 1e-52 179.2 1.0 1e-52 179.2 1.0 2.0 2 0 0 2 2 2 1 Amino acid kinase family ACT_7 PF13840.6 AIF83009.1 - 1.2e-21 76.3 2.2 1.9e-10 40.4 0.1 2.5 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 AIF83009.1 - 1.5e-19 69.4 0.4 8.2e-09 35.1 0.1 2.9 2 0 0 2 2 2 2 ACT domain ACT_6 PF13740.6 AIF83009.1 - 0.039 13.9 1.9 0.35 10.9 0.1 3.1 2 1 0 3 3 3 0 ACT domain PCNA_N PF00705.18 AIF83010.1 - 3.1e-17 62.5 0.0 3e-16 59.3 0.0 2.0 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 AIF83010.1 - 6e-17 62.0 0.1 1.1e-14 54.7 0.0 2.7 2 1 0 2 2 2 2 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 AIF83010.1 - 1.5e-06 27.5 0.1 0.0061 15.7 0.1 2.1 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 AIF83010.1 - 0.0003 20.3 0.0 0.00039 19.9 0.0 1.1 1 0 0 1 1 1 1 Rad9 Cation_efflux PF01545.21 AIF83011.1 - 3.9e-33 114.9 14.0 4.8e-33 114.6 14.0 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 AIF83011.1 - 3.5e-05 23.9 0.0 8e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF4396 PF14342.6 AIF83011.1 - 0.081 13.3 1.2 0.21 11.9 0.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4396) ABA_WDS PF02496.16 AIF83011.1 - 0.19 12.2 0.0 0.35 11.4 0.0 1.4 1 0 0 1 1 1 0 ABA/WDS induced protein GARS_A PF01071.19 AIF83012.1 - 2.8e-16 59.8 0.0 6.6e-16 58.7 0.0 1.6 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_C PF02843.16 AIF83012.1 - 1.3e-09 38.2 0.0 6.8e-09 35.9 0.0 2.3 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain AsnC_trans_reg PF01037.21 AIF83013.1 - 1.2e-14 54.0 0.2 1.3e-14 53.9 0.2 1.1 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain GYD PF08734.11 AIF83013.1 - 0.001 18.9 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 GYD domain NapD PF03927.13 AIF83013.1 - 0.031 14.3 0.6 0.038 14.0 0.6 1.2 1 0 0 1 1 1 0 NapD protein MatB PF16449.5 AIF83013.1 - 0.087 12.6 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Fimbrillin MatB PhoD PF09423.10 AIF83014.1 - 3.5e-09 36.1 0.9 0.00048 19.2 1.2 2.8 3 0 0 3 3 3 2 PhoD-like phosphatase KdpC PF02669.15 AIF83017.1 - 5.2e-37 127.4 0.1 1.5e-21 77.0 0.0 2.0 1 1 1 2 2 2 2 K+-transporting ATPase, c chain E1-E2_ATPase PF00122.20 AIF83018.1 - 1.2e-34 119.5 0.6 1.2e-34 119.5 0.6 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AIF83018.1 - 2.2e-26 93.4 1.5 4.9e-26 92.3 1.5 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AIF83018.1 - 0.00059 19.7 3.6 0.00094 19.0 1.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AIF83018.1 - 0.0044 17.4 0.0 0.017 15.5 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase LPG_synthase_TM PF03706.13 AIF83018.1 - 1.5 8.3 12.4 0.16 11.5 4.6 2.5 3 0 0 3 3 3 0 Lysylphosphatidylglycerol synthase TM region KdpA PF03814.15 AIF83019.1 - 7.3e-89 298.4 30.0 1.3e-88 297.6 30.0 1.4 1 1 0 1 1 1 1 Potassium-transporting ATPase A subunit MscS_TM PF12794.7 AIF83019.1 - 4.1 6.2 9.2 0.64 8.8 1.0 2.6 2 1 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 KdpA PF03814.15 AIF83020.1 - 2.2e-61 207.7 6.4 2.6e-61 207.5 6.4 1.0 1 0 0 1 1 1 1 Potassium-transporting ATPase A subunit DHHC PF01529.20 AIF83020.1 - 1.6 8.8 5.5 7.5 6.7 0.6 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase TFIIS_C PF01096.18 AIF83021.1 - 1.8e-18 66.0 7.2 1.8e-18 66.0 7.2 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) zf-ribbon_3 PF13248.6 AIF83021.1 - 5.4e-05 22.5 11.4 0.00071 18.9 2.1 3.4 3 1 0 3 3 3 2 zinc-ribbon domain RNA_POL_M_15KD PF02150.16 AIF83021.1 - 5.6e-05 22.9 8.4 0.00086 19.1 0.9 2.7 2 1 0 2 2 2 1 RNA polymerases M/15 Kd subunit DZR PF12773.7 AIF83021.1 - 0.00026 20.9 12.3 0.00029 20.8 2.1 2.8 1 1 0 2 2 2 1 Double zinc ribbon TF_Zn_Ribbon PF08271.12 AIF83021.1 - 0.00094 18.7 8.9 0.04 13.4 1.5 2.5 2 1 0 2 2 2 2 TFIIB zinc-binding zinc-ribbons_6 PF07191.12 AIF83021.1 - 0.0017 18.3 9.2 0.014 15.3 0.5 2.5 2 1 0 2 2 2 1 zinc-ribbons zinc_ribbon_4 PF13717.6 AIF83021.1 - 0.0026 17.6 16.4 0.13 12.2 1.3 4.2 3 1 0 3 3 3 1 zinc-ribbon domain zf-DNA_Pol PF08996.10 AIF83021.1 - 0.0042 16.9 0.6 0.0042 16.9 0.6 1.7 2 1 0 2 2 2 1 DNA Polymerase alpha zinc finger Prok-RING_1 PF14446.6 AIF83021.1 - 0.0045 16.9 1.6 0.0045 16.9 1.6 2.7 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 OrfB_Zn_ribbon PF07282.11 AIF83021.1 - 0.012 15.5 1.2 0.012 15.5 1.2 2.9 1 1 2 3 3 3 0 Putative transposase DNA-binding domain Baculo_LEF5_C PF11792.8 AIF83021.1 - 0.019 14.6 5.6 0.021 14.5 0.0 2.7 2 1 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain DUF4428 PF14471.6 AIF83021.1 - 0.023 14.6 1.4 0.13 12.2 0.7 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) Zn_Tnp_IS1595 PF12760.7 AIF83021.1 - 0.033 14.2 0.4 0.033 14.2 0.4 3.2 2 1 1 3 3 3 0 Transposase zinc-ribbon domain RPA_interact_C PF14768.6 AIF83021.1 - 0.038 14.6 7.0 3.1 8.4 7.0 2.8 1 1 0 1 1 1 0 Replication protein A interacting C-terminal Zn-ribbon_8 PF09723.10 AIF83021.1 - 0.077 13.1 13.0 15 5.8 0.3 4.1 3 1 1 4 4 4 0 Zinc ribbon domain zf_UBZ PF18439.1 AIF83021.1 - 0.11 12.1 11.7 16 5.2 0.2 4.1 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger DNA_RNApol_7kD PF03604.13 AIF83021.1 - 0.12 12.1 10.0 0.11 12.2 1.6 3.2 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit UPF0547 PF10571.9 AIF83021.1 - 0.16 12.1 10.0 0.6 10.2 0.1 3.7 4 0 0 4 4 4 0 Uncharacterised protein family UPF0547 Cript PF10235.9 AIF83021.1 - 0.19 12.3 0.6 0.19 12.3 0.6 2.6 1 1 2 3 3 3 0 Microtubule-associated protein CRIPT zf-SNAP50_C PF12251.8 AIF83021.1 - 0.19 11.3 3.9 0.068 12.8 0.7 1.7 2 0 0 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal zf-ZPR1 PF03367.13 AIF83021.1 - 0.27 11.1 7.8 0.88 9.4 0.5 2.5 3 0 0 3 3 3 0 ZPR1 zinc-finger domain A2L_zn_ribbon PF08792.10 AIF83021.1 - 0.3 10.9 12.8 1.6 8.6 0.1 4.0 4 0 0 4 4 4 0 A2L zinc ribbon domain PHD PF00628.29 AIF83021.1 - 0.7 9.8 11.2 3 7.8 1.3 2.9 2 1 0 2 2 2 0 PHD-finger Elf1 PF05129.13 AIF83021.1 - 0.72 9.9 9.8 0.15 12.2 2.1 2.9 2 2 0 2 2 2 0 Transcription elongation factor Elf1 like HypA PF01155.19 AIF83021.1 - 0.75 9.8 11.2 2.1 8.4 2.2 3.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_4 PF07975.12 AIF83021.1 - 1.2 9.4 11.6 1.8 8.9 0.5 3.3 2 2 2 4 4 4 0 TFIIH C1-like domain zf-TFIIB PF13453.6 AIF83021.1 - 1.7 8.0 13.6 1.7 8.0 2.2 2.9 2 2 0 2 2 2 0 Transcription factor zinc-finger DnaJ_CXXCXGXG PF00684.19 AIF83021.1 - 1.9 8.9 8.8 7.2e+02 0.6 9.0 2.5 1 1 0 1 1 1 0 DnaJ central domain zinc_ribbon_2 PF13240.6 AIF83021.1 - 2 8.3 15.7 0.11 12.2 3.6 3.4 3 1 0 3 3 3 0 zinc-ribbon domain DUF3797 PF12677.7 AIF83021.1 - 2 8.3 0.0 2 8.3 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF3797) zinc_ribbon_9 PF14369.6 AIF83021.1 - 2.3 8.5 9.3 9.9 6.5 2.8 3.2 3 1 0 3 3 3 0 zinc-ribbon zinc_ribbon_5 PF13719.6 AIF83021.1 - 6.5 6.6 16.8 14 5.6 0.8 4.1 3 1 0 3 3 3 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 AIF83021.1 - 7 6.5 19.2 1.3 8.8 0.3 4.1 4 0 0 4 4 4 0 Rubredoxin metal binding domain zf-IS66 PF13005.7 AIF83021.1 - 7.9 7.0 11.9 1.3 9.4 3.1 3.4 3 1 0 3 3 3 0 zinc-finger binding domain of transposase IS66 TackOD1 PF18551.1 AIF83021.1 - 8.6 6.0 10.3 3 7.5 1.1 2.8 2 2 0 2 2 2 0 Thaumarchaeal output domain 1 RNA_pol_L_2 PF13656.6 AIF83022.1 - 3.6e-13 49.1 0.0 4.2e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain LGFP PF08310.11 AIF83023.1 - 0.19 12.3 0.2 35 5.0 0.1 2.6 2 0 0 2 2 2 0 LGFP repeat MarR PF01047.22 AIF83024.1 - 9.6e-14 51.1 0.0 1.9e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 AIF83024.1 - 2e-07 30.8 0.0 3.2e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 AIF83024.1 - 9e-07 29.3 0.1 4.2e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 Winged helix DNA-binding domain TrmB PF01978.19 AIF83024.1 - 0.0012 18.6 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB TFIIE_alpha PF02002.17 AIF83024.1 - 0.0031 17.4 0.2 0.0043 16.9 0.2 1.3 1 0 0 1 1 1 1 TFIIE alpha subunit PadR PF03551.14 AIF83024.1 - 0.0092 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family Fe_dep_repress PF01325.19 AIF83024.1 - 0.017 15.3 0.1 0.079 13.2 0.0 2.0 2 1 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain Rrf2 PF02082.20 AIF83024.1 - 0.021 15.2 0.0 0.042 14.2 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator B-block_TFIIIC PF04182.12 AIF83024.1 - 0.045 13.9 0.0 0.14 12.3 0.0 1.8 1 1 1 2 2 2 0 B-block binding subunit of TFIIIC HTH_Crp_2 PF13545.6 AIF83024.1 - 0.05 13.6 0.1 0.089 12.8 0.1 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain DUF2250 PF10007.9 AIF83024.1 - 0.087 13.0 0.0 0.46 10.6 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) MFS_1 PF07690.16 AIF83025.1 - 2.8e-40 138.3 56.4 5.5e-31 107.8 27.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3671 PF12420.8 AIF83025.1 - 4.9 7.3 5.7 12 6.0 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function Radical_SAM PF04055.21 AIF83026.1 - 6.3e-13 49.4 0.1 1.1e-12 48.7 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 AIF83026.1 - 0.0033 17.7 0.1 0.0076 16.5 0.1 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain CD225 PF04505.12 AIF83027.1 - 0.17 12.1 0.1 0.28 11.3 0.1 1.3 1 0 0 1 1 1 0 Interferon-induced transmembrane protein Phage_integr_3 PF16795.5 AIF83033.1 - 5.9e-09 36.0 0.2 9.7e-09 35.3 0.2 1.4 1 0 0 1 1 1 1 Archaeal phage integrase Med24_N PF11277.8 AIF83033.1 - 0.0051 14.9 0.1 0.0054 14.9 0.1 1.2 1 0 0 1 1 1 1 Mediator complex subunit 24 N-terminal DUF1989 PF09347.10 AIF83033.1 - 0.038 13.6 0.3 0.15 11.7 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1989) RGI1 PF10843.8 AIF83033.1 - 0.082 12.6 4.9 6.2 6.4 3.7 2.8 2 1 0 2 2 2 0 Respiratory growth induced protein 1 UPF0184 PF03670.13 AIF83033.1 - 0.11 12.9 0.0 0.36 11.2 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) Archaeal_AmoA PF12942.7 AIF83036.1 - 1.8e-116 386.3 16.9 2.2e-116 386.1 16.9 1.1 1 0 0 1 1 1 1 Archaeal ammonia monooxygenase subunit A (AmoA) DUF2436 PF10365.9 AIF83038.1 - 0.056 13.2 0.1 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2436) He_PIG PF05345.12 AIF83038.1 - 2.6 8.3 7.6 1.3 9.2 0.3 3.6 3 0 0 3 3 3 0 Putative Ig domain UDPG_MGDP_dh_N PF03721.14 AIF83043.1 - 1.2e-33 116.2 0.0 7.8e-33 113.6 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 AIF83043.1 - 1.5e-22 79.6 0.0 2.7e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 AIF83043.1 - 2.5e-21 76.0 0.0 1e-20 74.1 0.0 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_Gly3P_dh_N PF01210.23 AIF83043.1 - 1.3e-05 25.3 0.1 0.13 12.2 0.0 2.4 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 AIF83043.1 - 5.6e-05 22.6 0.2 0.0011 18.4 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 AIF83043.1 - 0.00061 19.7 0.0 0.0043 17.0 0.0 2.1 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 AIF83043.1 - 0.0022 18.6 0.4 1.3 9.7 0.0 3.5 3 1 1 4 4 4 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 AIF83043.1 - 0.0032 17.6 0.2 0.022 15.0 0.0 2.5 3 1 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 AIF83043.1 - 0.0062 16.8 0.0 0.06 13.6 0.0 2.4 2 0 0 2 2 2 1 TrkA-N domain AlaDh_PNT_C PF01262.21 AIF83043.1 - 0.013 14.8 0.1 0.026 13.8 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.21 AIF83043.1 - 0.099 12.0 1.7 0.57 9.5 0.4 2.2 2 0 0 2 2 2 0 ThiF family Methyltransf_31 PF13847.6 AIF83043.1 - 0.11 12.3 0.0 0.3 10.9 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain NAD_binding_7 PF13241.6 AIF83043.1 - 0.14 12.7 0.1 4.9 7.7 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding IF-2B PF01008.17 AIF83044.1 - 3.9e-91 305.2 0.1 4.6e-91 304.9 0.1 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family FeS_assembly_P PF01883.19 AIF83045.1 - 2.8e-18 65.8 0.0 6e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein PqqD PF05402.12 AIF83045.1 - 3.5e-09 36.8 0.1 5.7e-09 36.2 0.1 1.3 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) Methyltransf_4 PF02390.17 AIF83046.1 - 2.6e-09 36.8 0.0 3.3e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 AIF83046.1 - 9.8e-06 26.2 0.0 1.5e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF83046.1 - 6.7e-05 23.5 0.0 0.00011 22.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF83046.1 - 0.002 18.0 0.0 0.0024 17.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 AIF83046.1 - 0.0041 16.7 0.0 0.0064 16.1 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.12 AIF83046.1 - 0.0054 17.5 0.0 0.0089 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_33 PF10017.9 AIF83046.1 - 0.034 13.3 0.0 0.044 12.9 0.0 1.1 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent HTH_45 PF14947.6 AIF83047.1 - 7.2e-12 45.1 0.0 8.3e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_27 PF13463.6 AIF83047.1 - 0.019 15.4 0.0 0.027 15.0 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain DUF1495 PF07381.11 AIF83047.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) TrmB PF01978.19 AIF83047.1 - 0.16 11.8 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB FapA PF03961.13 AIF83048.1 - 2.7e-05 23.0 27.5 6e-05 21.8 10.8 2.7 1 1 2 3 3 3 3 Flagellar Assembly Protein A Bactofilin PF04519.13 AIF83048.1 - 0.017 15.4 2.4 0.017 15.4 2.4 5.7 1 1 5 6 6 6 0 Polymer-forming cytoskeletal MFS_1 PF07690.16 AIF83049.1 - 9.5e-56 189.2 72.9 6.8e-50 170.0 49.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 AIF83049.1 - 4.3e-08 32.4 28.9 9.7e-06 24.7 28.9 2.2 1 1 0 1 1 1 1 MFS_1 like family Sugar_tr PF00083.24 AIF83049.1 - 8e-07 28.3 13.5 8e-07 28.3 13.5 2.3 1 1 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.6 AIF83049.1 - 5.8e-05 21.8 40.6 0.00019 20.1 12.1 2.9 1 1 1 3 3 3 2 MFS/sugar transport protein MFS_4 PF06779.14 AIF83049.1 - 0.00011 21.6 17.9 0.00011 21.6 17.9 2.0 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 AIF83049.1 - 1.3 7.4 31.4 0.024 13.0 20.4 2.0 1 1 1 2 2 2 0 Transmembrane secretion effector DUF3098 PF11297.8 AIF83049.1 - 8.9 6.0 9.4 3.9 7.2 0.4 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3098) AHSA1 PF08327.11 AIF83051.1 - 2.4e-20 73.0 0.0 3.5e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 AIF83051.1 - 1.7e-05 25.1 0.3 2.4e-05 24.6 0.3 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIF83051.1 - 0.16 12.2 0.5 0.34 11.1 0.5 1.7 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Arginase PF00491.21 AIF83052.1 - 1.3e-29 103.6 0.0 1.6e-29 103.3 0.0 1.0 1 0 0 1 1 1 1 Arginase family HTH_20 PF12840.7 AIF83053.1 - 1.5e-11 44.2 0.6 2.2e-11 43.6 0.6 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 AIF83053.1 - 2.7e-06 27.2 0.0 4.7e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DUF3860 PF12976.7 AIF83053.1 - 0.1 12.6 0.0 0.21 11.7 0.0 1.6 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3860) AHSA1 PF08327.11 AIF83054.1 - 2.1e-09 37.7 0.0 2.5e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein PEGSRP PF07623.11 AIF83055.1 - 0.0064 16.2 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1584) zf-FCS PF06467.14 AIF83055.1 - 0.064 13.2 9.0 0.18 11.7 9.0 1.8 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif HGTP_anticodon PF03129.20 AIF83056.1 - 5.4e-18 64.9 0.0 1.3e-17 63.7 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AIF83056.1 - 1.3e-13 51.3 0.0 2.6e-12 47.1 0.0 2.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) zinc_ribbon_15 PF17032.5 AIF83056.1 - 0.051 14.3 0.4 0.14 12.9 0.3 1.8 1 1 0 1 1 1 0 zinc-ribbon family zf-C2HE PF16278.5 AIF83056.1 - 0.069 13.6 3.3 0.074 13.5 0.2 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C3HC PF07967.13 AIF83056.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 C3HC zinc finger-like zinc_ribbon_5 PF13719.6 AIF83056.1 - 0.15 11.9 0.2 0.15 11.9 0.2 2.2 3 0 0 3 3 3 0 zinc-ribbon domain Aminotran_1_2 PF00155.21 AIF83057.1 - 7.9e-60 202.9 0.0 8.8e-60 202.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 AIF83057.1 - 3.5e-05 23.3 0.0 6.6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 AIF83057.1 - 0.00012 21.2 0.0 0.0002 20.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AIF83057.1 - 0.0011 18.3 0.0 0.0017 17.7 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 AIF83057.1 - 0.0025 16.4 0.0 0.0041 15.7 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF1318 PF07027.12 AIF83058.1 - 0.3 11.5 3.5 0.65 10.5 3.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1318) Nop25 PF09805.9 AIF83058.1 - 2.8 8.4 7.9 3.2 8.2 7.9 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) VASP_tetra PF08776.11 AIF83059.1 - 0.085 12.4 4.2 3 7.5 4.2 2.1 1 1 0 1 1 1 0 VASP tetramerisation domain ATP-synt_Z PF16594.5 AIF83060.1 - 0.0013 18.2 0.0 0.78 9.3 0.0 2.3 2 0 0 2 2 2 2 Putative AtpZ or ATP-synthase-associated DUF308 PF03729.13 AIF83060.1 - 0.0075 16.6 2.5 0.23 11.8 0.1 2.8 2 1 1 3 3 3 2 Short repeat of unknown function (DUF308) BacA PF02673.18 AIF83060.1 - 0.012 15.3 0.1 0.017 14.8 0.1 1.4 1 1 0 1 1 1 0 Bacitracin resistance protein BacA Gram_pos_anchor PF00746.21 AIF83060.1 - 0.013 15.4 0.8 2.8 8.0 0.3 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Pox_A14 PF05767.12 AIF83060.1 - 0.2 11.8 2.3 1 9.5 2.3 1.9 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 F420_oxidored PF03807.17 AIF83061.1 - 6.8e-14 52.2 0.0 1.2e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 AIF83061.1 - 0.00056 19.9 0.0 0.00076 19.5 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus PDH PF02153.17 AIF83061.1 - 0.0018 17.3 0.0 0.0029 16.7 0.0 1.4 1 1 0 1 1 1 1 Prephenate dehydrogenase 3HCDH_N PF02737.18 AIF83061.1 - 0.028 14.3 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain His_Phos_1 PF00300.22 AIF83062.1 - 4.1e-45 153.9 0.0 4.6e-45 153.7 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Yip1 PF04893.17 AIF83063.1 - 0.0014 18.3 1.6 0.0018 18.0 1.6 1.0 1 0 0 1 1 1 1 Yip1 domain Virul_fac_BrkB PF03631.15 AIF83063.1 - 0.0087 15.7 1.0 0.011 15.4 1.0 1.0 1 0 0 1 1 1 1 Virulence factor BrkB DUF5367 PF17329.2 AIF83063.1 - 0.0092 16.1 1.6 0.084 13.0 0.2 2.0 2 0 0 2 2 2 1 Family of unknown function (DUF5367) TNFR_16_TM PF18422.1 AIF83063.1 - 0.031 14.2 0.1 0.06 13.3 0.1 1.5 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain LapA_dom PF06305.11 AIF83063.1 - 0.045 13.6 0.1 0.045 13.6 0.1 1.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain FeoB_associated PF12669.7 AIF83063.1 - 0.088 13.2 0.2 0.088 13.2 0.2 2.1 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Baculo_E56 PF04639.12 AIF83063.1 - 0.1 11.9 0.3 0.1 11.9 0.3 1.6 2 0 0 2 2 2 0 Baculoviral E56 protein, specific to ODV envelope DUF1129 PF06570.11 AIF83063.1 - 0.22 11.0 1.6 0.76 9.2 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) Cytochrome-c551 PF10643.9 AIF83063.1 - 0.25 10.9 2.1 8.3 5.9 1.1 2.0 1 1 1 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 DUF2207 PF09972.9 AIF83063.1 - 0.27 9.9 0.6 0.27 9.9 0.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) COX2 PF00116.20 AIF83064.1 - 9.8e-18 64.2 0.7 1.4e-14 54.0 0.0 2.1 1 1 1 2 2 2 2 Cytochrome C oxidase subunit II, periplasmic domain Cupredoxin_1 PF13473.6 AIF83064.1 - 0.00083 19.4 0.0 0.001 19.2 0.0 1.3 1 0 0 1 1 1 1 Cupredoxin-like domain COX1 PF00115.20 AIF83065.1 - 3e-131 438.2 66.6 3.5e-131 438.0 66.6 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Cupredoxin_1 PF13473.6 AIF83066.1 - 1.2e-13 51.0 0.2 7.6e-09 35.6 0.0 2.7 2 2 0 2 2 2 2 Cupredoxin-like domain Copper-bind PF00127.20 AIF83066.1 - 1.2e-13 51.3 0.5 2.8e-07 30.9 0.1 2.2 2 0 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Phage_30_8 PF06019.11 AIF83066.1 - 0.17 11.8 0.0 1.2 9.1 0.0 2.0 2 0 0 2 2 2 0 Phage GP30.8 protein COX15-CtaA PF02628.15 AIF83067.1 - 6.7e-19 68.1 13.5 7.9e-13 48.2 6.3 2.0 1 1 1 2 2 2 2 Cytochrome oxidase assembly protein DUF2231 PF09990.9 AIF83067.1 - 0.21 12.0 5.6 0.11 12.9 3.1 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2231) DUF805 PF05656.14 AIF83067.1 - 0.51 10.8 3.0 0.29 11.6 1.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF805) HCV_NS4a PF01006.20 AIF83067.1 - 1.1 9.1 4.4 16 5.4 1.1 2.7 2 1 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a ECF_trnsprt PF12822.7 AIF83068.1 - 0.2 11.7 10.5 0.67 10.0 7.6 2.6 3 1 0 3 3 3 0 ECF transporter, substrate-specific component Fe-ADH PF00465.19 AIF83069.1 - 2.4e-50 171.4 0.0 1.5e-49 168.8 0.0 1.8 1 1 1 2 2 2 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 AIF83069.1 - 7.1e-16 58.7 0.0 9.5e-16 58.2 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase PFK PF00365.20 AIF83069.1 - 0.014 14.8 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Phosphofructokinase DHQ_synthase PF01761.20 AIF83069.1 - 0.071 12.3 0.0 6.3 5.9 0.0 2.2 2 0 0 2 2 2 0 3-dehydroquinate synthase Polyketide_cyc2 PF10604.9 AIF83070.1 - 6.1e-10 39.5 0.0 7.7e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIF83070.1 - 7.3e-08 32.7 0.0 1.1e-07 32.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.11 AIF83070.1 - 6.3e-07 29.7 0.0 9e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein SGL PF08450.12 AIF83071.1 - 4.8e-08 32.9 1.2 0.00082 19.0 0.1 3.5 2 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 AIF83071.1 - 1.2e-06 28.6 6.7 0.038 14.2 0.0 5.9 6 0 0 6 6 6 1 Arylesterase Lactonase PF10282.9 AIF83071.1 - 1.9e-06 27.4 1.1 0.017 14.4 0.4 3.4 1 1 0 2 2 2 2 Lactonase, 7-bladed beta-propeller PilJ_C PF18223.1 AIF83071.1 - 0.046 14.2 1.9 28 5.3 0.0 3.9 2 1 0 3 3 3 0 Pili PilJ C-terminal domain NHL PF01436.21 AIF83071.1 - 0.12 12.4 7.9 59 4.0 0.0 6.0 7 0 0 7 7 7 0 NHL repeat DUF4369 PF14289.6 AIF83071.1 - 3.8 8.1 7.0 1.7 9.2 0.4 3.2 3 2 1 4 4 4 0 Domain of unknown function (DUF4369) TetR_N PF00440.23 AIF83074.1 - 8.3e-18 63.9 0.4 2e-17 62.7 0.1 1.8 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.6 AIF83074.1 - 1.7e-12 47.6 0.5 3.6e-12 46.5 0.1 1.9 2 0 0 2 2 2 1 BetI-type transcriptional repressor, C-terminal TetR_C_7 PF14246.6 AIF83074.1 - 1.2e-06 28.6 0.1 1.1e-05 25.5 0.0 2.1 2 0 0 2 2 2 1 AefR-like transcriptional repressor, C-terminal domain TetR_C_17 PF17922.1 AIF83074.1 - 2.6e-06 27.4 0.7 2.2e-05 24.5 0.1 2.3 1 1 1 2 2 2 1 Tetracyclin repressor-like, C-terminal domain TetR_C_31 PF17940.1 AIF83074.1 - 0.00039 20.6 0.0 0.0012 19.1 0.0 1.7 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_11 PF16859.5 AIF83074.1 - 0.0019 18.5 0.4 0.0091 16.3 0.0 2.2 2 1 0 3 3 3 1 Tetracyclin repressor-like, C-terminal domain TetR_C_2 PF08361.11 AIF83074.1 - 0.0022 18.1 0.1 0.0054 16.8 0.0 1.7 2 0 0 2 2 2 1 MAATS-type transcriptional repressor, C-terminal region HTH_Tnp_1_2 PF13022.6 AIF83074.1 - 0.0029 17.8 0.7 0.019 15.1 0.1 2.3 2 1 0 2 2 2 1 Helix-turn-helix of insertion element transposase TetR_C_37 PF18665.1 AIF83074.1 - 0.004 17.8 0.8 0.24 12.0 0.8 2.3 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_36 PF18598.1 AIF83074.1 - 0.06 13.3 0.1 0.35 10.8 0.0 2.0 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Coat_F PF07875.12 AIF83074.1 - 0.067 13.4 0.2 0.8 10.0 0.0 2.3 2 0 0 2 2 2 0 Coat F domain CPP1-like PF11833.8 AIF83075.1 - 0.029 14.0 0.6 0.029 14.0 0.6 3.2 2 1 0 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF3792 PF12670.7 AIF83076.1 - 0.029 14.5 0.4 0.029 14.5 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) DUF4229 PF14012.6 AIF83076.1 - 1.7 8.8 6.6 0.21 11.7 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) DUF1326 PF07040.11 AIF83077.1 - 2e-56 190.8 0.2 2.3e-56 190.6 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) PepSY PF03413.19 AIF83078.1 - 3.5e-05 24.3 0.5 3.5e-05 24.3 0.5 1.6 2 1 0 2 2 2 1 Peptidase propeptide and YPEB domain DUF4367 PF14285.6 AIF83079.1 - 0.0029 18.0 0.1 0.093 13.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4367) GSDH PF07995.11 AIF83081.1 - 2.1e-65 221.2 0.1 1.8e-51 175.5 0.3 2.1 2 0 0 2 2 2 2 Glucose / Sorbosone dehydrogenase PD40 PF07676.12 AIF83081.1 - 0.0056 16.6 0.7 0.25 11.3 0.0 3.2 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Phytase-like PF13449.6 AIF83081.1 - 0.012 15.5 0.0 4.1 7.3 0.0 3.0 2 1 1 3 3 3 0 Esterase-like activity of phytase Lactonase PF10282.9 AIF83081.1 - 0.013 14.8 0.0 1.5 8.0 0.0 2.7 2 1 1 3 3 3 0 Lactonase, 7-bladed beta-propeller NHL PF01436.21 AIF83081.1 - 0.036 14.1 0.0 0.63 10.2 0.0 3.0 3 0 0 3 3 3 0 NHL repeat SGL PF08450.12 AIF83081.1 - 0.052 13.1 0.1 26 4.3 0.0 3.6 2 1 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Proteasome_A_N PF10584.9 AIF83081.1 - 0.18 11.5 0.4 15 5.4 0.0 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature HEM4 PF02602.15 AIF83084.1 - 5.7e-41 140.4 0.1 6.6e-41 140.2 0.1 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD DUF1308 PF07000.11 AIF83084.1 - 0.013 15.4 0.1 0.25 11.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1308) NMT1 PF09084.11 AIF83084.1 - 0.062 13.2 0.1 0.35 10.8 0.0 2.2 3 0 0 3 3 3 0 NMT1/THI5 like Nitro_FeMo-Co PF02579.17 AIF83084.1 - 0.1 12.9 0.1 6.7 7.1 0.0 3.0 3 0 0 3 3 3 0 Dinitrogenase iron-molybdenum cofactor TP_methylase PF00590.20 AIF83085.1 - 1.8e-48 165.3 0.3 2.1e-48 165.1 0.3 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF3155 PF11352.8 AIF83085.1 - 0.03 14.8 0.1 0.43 11.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3155) ApbA PF02558.16 AIF83085.1 - 0.065 12.9 0.0 0.17 11.5 0.1 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Porphobil_deam PF01379.20 AIF83086.1 - 6e-72 241.4 0.2 8.2e-72 241.0 0.2 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 AIF83086.1 - 4.7e-18 65.3 0.1 1.3e-17 63.9 0.1 1.8 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain LysR_substrate PF03466.20 AIF83086.1 - 7.1e-05 22.3 0.0 0.033 13.6 0.0 3.2 3 0 0 3 3 3 1 LysR substrate binding domain YfdX PF10938.8 AIF83086.1 - 0.09 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 YfdX protein PAS_4 PF08448.10 AIF83086.1 - 0.14 12.4 0.0 1.5 9.1 0.0 2.4 3 0 0 3 3 3 0 PAS fold Aminotran_3 PF00202.21 AIF83087.1 - 4e-65 220.1 0.0 5e-65 219.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 AIF83087.1 - 2.9e-09 36.6 0.0 4.4e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Chalcone_2 PF16035.5 AIF83088.1 - 0.052 13.3 0.0 0.068 12.9 0.0 1.2 1 0 0 1 1 1 0 Chalcone isomerase like DUF5067 PF16729.5 AIF83089.1 - 0.0042 17.0 2.1 0.17 11.8 0.4 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF5067) DUF3108 PF11306.8 AIF83089.1 - 0.009 16.0 0.1 0.022 14.7 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3108) EVE PF01878.18 AIF83090.1 - 2e-40 138.1 0.2 2.3e-40 137.9 0.2 1.0 1 0 0 1 1 1 1 EVE domain TruD PF01142.18 AIF83091.1 - 1.2e-91 307.6 0.0 1.4e-91 307.4 0.0 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) PilJ PF13675.6 AIF83091.1 - 0.08 13.0 0.1 6.3 6.9 0.0 2.3 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Clathrin_H_link PF13838.6 AIF83091.1 - 0.11 12.4 0.2 8.1 6.4 0.0 3.0 3 0 0 3 3 3 0 Clathrin-H-link HTH_45 PF14947.6 AIF83092.1 - 2.4e-07 30.6 0.2 3.1e-07 30.3 0.2 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIF83092.1 - 0.00048 20.0 0.1 0.00081 19.3 0.1 1.3 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIF83092.1 - 0.0021 17.9 0.0 0.003 17.4 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Roughex PF06020.11 AIF83092.1 - 0.032 13.3 0.0 0.037 13.1 0.0 1.0 1 0 0 1 1 1 0 Drosophila roughex protein PadR PF03551.14 AIF83092.1 - 0.036 14.0 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family Trypsin_2 PF13365.6 AIF83095.1 - 4e-35 121.9 1.1 4e-35 121.9 1.1 1.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 AIF83095.1 - 2.3e-16 59.9 0.7 2.1e-15 56.8 0.1 2.6 2 0 0 2 2 2 1 PDZ domain Trypsin PF00089.26 AIF83095.1 - 7.5e-16 58.6 0.7 1.5e-15 57.6 0.2 1.7 1 1 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 AIF83095.1 - 1e-05 25.3 9.1 0.0035 17.2 0.1 3.9 4 0 0 4 4 4 2 PDZ domain PDZ PF00595.24 AIF83095.1 - 0.00024 21.4 1.0 0.77 10.1 0.1 3.7 3 1 0 3 3 3 1 PDZ domain Tricorn_PDZ PF14685.6 AIF83095.1 - 0.0077 16.2 2.1 0.0083 16.1 0.1 2.2 3 0 0 3 3 3 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 AIF83095.1 - 0.016 13.9 1.7 0.12 11.0 0.7 2.1 2 0 0 2 2 2 0 Peptidase S46 Peptidase_S29 PF02907.15 AIF83095.1 - 0.028 14.2 0.0 0.066 13.0 0.0 1.6 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Cas_Cas4 PF01930.17 AIF83096.1 - 0.00067 19.8 0.2 0.001 19.2 0.2 1.6 1 1 0 1 1 1 1 Domain of unknown function DUF83 LEA_2 PF03168.13 AIF83098.1 - 0.0045 17.5 0.4 0.014 15.9 0.4 1.9 1 1 0 1 1 1 1 Late embryogenesis abundant protein DUF5640 PF18692.1 AIF83098.1 - 0.14 12.2 1.2 1.4 9.0 0.0 2.6 3 1 1 4 4 4 0 Family of unknown function (DUF5640) MacB_PCD PF12704.7 AIF83098.1 - 0.17 12.2 5.3 0.26 11.6 5.3 1.4 1 1 0 1 1 1 0 MacB-like periplasmic core domain Gp5_C PF06715.12 AIF83098.1 - 1.4 9.2 6.4 3.1 8.1 0.1 3.5 3 0 0 3 3 3 0 Gp5 C-terminal repeat (3 copies) AA_kinase PF00696.28 AIF83100.1 - 5.4e-30 104.8 2.6 8.5e-30 104.1 2.6 1.3 1 1 0 1 1 1 1 Amino acid kinase family HD PF01966.22 AIF83101.1 - 1.1e-13 51.4 0.3 2.5e-13 50.3 0.3 1.7 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 AIF83101.1 - 0.0077 15.7 0.1 0.016 14.7 0.1 1.5 1 0 0 1 1 1 1 HDOD domain WDCP PF15390.6 AIF83101.1 - 0.056 11.8 0.1 0.075 11.4 0.1 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Thymidylate_kin PF02223.17 AIF83102.1 - 4.7e-32 111.2 0.0 5.5e-32 110.9 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 AIF83102.1 - 0.029 14.6 0.0 0.038 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain CPT PF07931.12 AIF83102.1 - 0.04 13.8 0.0 0.097 12.5 0.1 1.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 AIF83102.1 - 0.044 14.3 0.0 0.067 13.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain RecA PF00154.21 AIF83102.1 - 0.05 13.1 0.0 0.085 12.3 0.0 1.3 1 0 0 1 1 1 0 recA bacterial DNA recombination protein CBP_BcsQ PF06564.12 AIF83102.1 - 0.083 12.4 0.1 2.1 7.7 0.0 2.2 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ C1_2 PF03107.16 AIF83104.1 - 0.00032 20.9 13.6 0.0066 16.7 1.8 2.1 1 1 1 2 2 2 2 C1 domain zf-ribbon_3 PF13248.6 AIF83104.1 - 0.0017 17.7 11.4 0.2 11.1 0.9 3.4 3 0 0 3 3 3 2 zinc-ribbon domain DUF1610 PF07754.11 AIF83104.1 - 0.0063 16.5 11.4 0.027 14.4 5.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1610) zf-CHY PF05495.12 AIF83104.1 - 0.013 16.0 10.9 0.052 14.1 10.9 1.8 1 1 0 1 1 1 0 CHY zinc finger HypA PF01155.19 AIF83104.1 - 0.02 14.9 13.9 0.046 13.7 4.0 2.0 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-HIT PF04438.16 AIF83104.1 - 0.052 13.4 5.3 0.052 13.4 5.3 2.9 2 1 0 2 2 2 0 HIT zinc finger DZR PF12773.7 AIF83104.1 - 0.057 13.4 13.6 3.8 7.6 13.7 2.4 1 1 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 AIF83104.1 - 0.081 12.9 18.4 5.1 7.2 18.4 2.5 1 1 0 1 1 1 0 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.10 AIF83104.1 - 0.096 12.8 17.9 0.56 10.4 0.6 3.3 1 1 0 2 2 2 0 Zinc ribbon domain zf-RING_5 PF14634.6 AIF83104.1 - 0.12 12.3 12.2 1.3 9.0 1.8 2.4 2 1 0 2 2 2 0 zinc-RING finger domain PhnA_Zn_Ribbon PF08274.12 AIF83104.1 - 0.16 11.9 11.0 7.6 6.6 0.3 3.9 4 0 0 4 4 4 0 PhnA Zinc-Ribbon Sgf11 PF08209.11 AIF83104.1 - 0.17 11.5 14.3 1.5 8.4 0.1 3.9 3 1 1 4 4 4 0 Sgf11 (transcriptional regulation protein) zinc_ribbon_9 PF14369.6 AIF83104.1 - 0.22 11.8 9.7 0.12 12.6 1.5 2.5 2 1 0 2 2 2 0 zinc-ribbon OrfB_Zn_ribbon PF07282.11 AIF83104.1 - 0.3 11.1 14.1 0.4 10.6 2.2 2.7 1 1 1 2 2 2 0 Putative transposase DNA-binding domain ZZ PF00569.17 AIF83104.1 - 0.51 10.2 13.7 8.6 6.3 3.2 3.4 3 1 0 3 3 3 0 Zinc finger, ZZ type Elf1 PF05129.13 AIF83104.1 - 0.54 10.3 10.8 3.2 7.9 8.0 2.7 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf_C2H2_10 PF18414.1 AIF83104.1 - 0.72 9.4 13.4 0.25 10.9 1.9 3.2 3 0 0 3 3 3 0 C2H2 type zinc-finger Rubredoxin PF00301.20 AIF83104.1 - 0.78 9.8 0.2 0.78 9.8 0.2 3.7 1 1 3 4 4 4 0 Rubredoxin CpXC PF14353.6 AIF83104.1 - 1.3 9.1 11.8 1.9 8.5 0.9 3.2 1 1 2 3 3 3 0 CpXC protein Zn_Tnp_IS1 PF03811.13 AIF83104.1 - 1.8 8.3 12.1 1.5 8.6 8.3 2.7 2 1 0 2 2 2 0 InsA N-terminal domain PolC_DP2 PF03833.13 AIF83104.1 - 1.9 6.2 7.2 2 6.2 7.2 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 PHD PF00628.29 AIF83104.1 - 3.2 7.7 16.9 49 3.9 10.1 3.8 1 1 0 1 1 1 0 PHD-finger Zn_Tnp_IS91 PF14319.6 AIF83104.1 - 3.3 7.8 13.3 1 9.5 1.6 2.3 1 1 1 2 2 2 0 Transposase zinc-binding domain zf-H2C2_2 PF13465.6 AIF83104.1 - 4.6 7.8 19.8 0.74 10.4 2.0 3.5 2 2 2 4 4 4 0 Zinc-finger double domain DUF4211 PF13926.6 AIF83104.1 - 4.7 7.3 7.0 0.74 9.9 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4211) Desulfoferrod_N PF06397.12 AIF83104.1 - 4.7 6.9 13.3 4.5 7.0 0.3 3.4 1 1 3 4 4 4 0 Desulfoferrodoxin, N-terminal domain NRDD PF13597.6 AIF83104.1 - 5.6 5.6 14.0 0.48 9.1 1.1 2.0 1 1 1 2 2 2 0 Anaerobic ribonucleoside-triphosphate reductase HscB_4_cys PF18256.1 AIF83104.1 - 6.7 6.6 15.3 0.1 12.5 2.4 2.6 2 1 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif HSP20 PF00011.21 AIF83105.1 - 2e-09 37.5 0.0 2.6e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AIF83105.1 - 5.1e-07 29.2 0.0 9.9e-07 28.2 0.0 1.5 1 1 0 1 1 1 1 HSP20-like domain found in ArsA ABC1 PF03109.16 AIF83106.1 - 1.1e-22 80.4 0.0 2.2e-22 79.5 0.0 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 AIF83106.1 - 0.031 14.2 0.7 0.19 11.6 0.7 2.2 1 1 0 1 1 1 0 Phosphotransferase enzyme family WaaY PF06176.11 AIF83106.1 - 0.053 13.1 0.1 0.1 12.2 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) DUF4795 PF16043.5 AIF83106.1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) OmpA_membrane PF01389.17 AIF83107.1 - 0.056 13.2 0.3 0.078 12.7 0.3 1.2 1 0 0 1 1 1 0 OmpA-like transmembrane domain NUDIX PF00293.28 AIF83108.1 - 6.6e-16 58.5 0.0 8.4e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain ComA PF02679.15 AIF83109.1 - 2.7e-59 200.6 0.2 3.9e-59 200.1 0.2 1.1 1 0 0 1 1 1 1 (2R)-phospho-3-sulfolactate synthase (ComA) MarR_2 PF12802.7 AIF83109.1 - 1.8e-05 24.5 0.0 3.7e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIF83109.1 - 0.014 15.3 0.1 0.034 14.0 0.1 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 AIF83109.1 - 0.023 14.6 0.1 0.05 13.5 0.1 1.6 1 0 0 1 1 1 0 MarR family NMT1_2 PF13379.6 AIF83110.1 - 2.4e-32 112.6 0.0 3.6e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 AIF83110.1 - 5.7e-12 46.0 0.0 8.8e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 AIF83110.1 - 1.3e-06 28.2 0.0 1.3e-05 24.9 0.0 2.1 1 1 1 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 AIF83110.1 - 8.5e-05 22.1 0.0 0.00061 19.3 0.0 2.0 1 1 1 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 NMT1_3 PF16868.5 AIF83110.1 - 0.0019 17.7 0.0 0.0034 16.9 0.0 1.3 1 0 0 1 1 1 1 NMT1-like family YflT PF11181.8 AIF83110.1 - 0.13 12.7 0.1 0.24 11.9 0.1 1.4 1 0 0 1 1 1 0 Heat induced stress protein YflT BPD_transp_1 PF00528.22 AIF83111.1 - 9e-18 64.7 18.3 9e-18 64.7 18.3 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Pterin_4a PF01329.19 AIF83112.1 - 5.3e-31 106.6 0.1 5.9e-31 106.5 0.1 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase SKG6 PF08693.10 AIF83113.1 - 0.19 11.1 0.4 0.19 11.1 0.4 2.0 2 0 0 2 2 2 0 Transmembrane alpha-helix domain SDA1 PF05285.12 AIF83114.1 - 7.7 5.8 14.9 9.7 5.5 14.9 1.3 1 0 0 1 1 1 0 SDA1 MG2 PF01835.19 AIF83115.1 - 0.0082 16.6 0.0 0.33 11.4 0.0 2.5 2 0 0 2 2 2 1 MG2 domain DnaJ_CXXCXGXG PF00684.19 AIF83117.1 - 0.00012 22.3 9.3 0.00018 21.8 9.3 1.2 1 0 0 1 1 1 1 DnaJ central domain SPATA25 PF15218.6 AIF83117.1 - 0.017 14.9 0.7 0.017 14.9 0.7 1.0 1 0 0 1 1 1 0 Spermatogenesis-associated protein 25 Anti-TRAP PF15777.5 AIF83117.1 - 0.14 12.1 8.7 0.8 9.7 0.9 2.2 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein ABC2_membrane_5 PF13346.6 AIF83118.1 - 9.1 5.8 26.9 0.016 14.8 7.9 2.8 2 1 1 3 3 3 0 ABC-2 family transporter protein Tautomerase PF01361.21 AIF83119.1 - 4e-14 52.3 0.1 4.8e-14 52.0 0.1 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_2 PF14552.6 AIF83119.1 - 2.4e-11 43.6 0.1 2.5e-11 43.5 0.1 1.0 1 0 0 1 1 1 1 Tautomerase enzyme CRISPR_Cas2 PF09827.9 AIF83119.1 - 0.14 12.3 0.0 0.16 12.2 0.0 1.1 1 0 0 1 1 1 0 CRISPR associated protein Cas2 Gram_pos_anchor PF00746.21 AIF83120.1 - 0.081 12.9 0.2 0.081 12.9 0.2 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif PIRT PF15099.6 AIF83120.1 - 0.1 12.2 0.7 7.3 6.2 0.1 2.2 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family DUF11 PF01345.18 AIF83120.1 - 0.1 12.9 2.8 0.32 11.3 0.4 2.3 2 1 0 2 2 2 0 Domain of unknown function DUF11 DUF4198 PF10670.9 AIF83120.1 - 0.11 12.9 0.0 0.13 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) Peptidase_M20 PF01546.28 AIF83121.1 - 5.8e-35 120.9 0.0 8.6e-35 120.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AIF83121.1 - 6.8e-16 58.2 0.0 1.2e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Copper-bind PF00127.20 AIF83122.1 - 1.2e-07 32.0 0.0 1.5e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF83122.1 - 4.3e-05 23.6 0.0 6.2e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 Cupredoxin-like domain ATP-grasp_5 PF13549.6 AIF83124.1 - 1.3e-83 279.8 0.7 2e-83 279.2 0.3 1.5 2 0 0 2 2 2 1 ATP-grasp domain Succ_CoA_lig PF13607.6 AIF83124.1 - 2.9e-54 182.6 1.4 2.9e-54 182.6 1.4 1.9 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 AIF83124.1 - 7.9e-23 81.2 0.3 6e-21 75.1 0.0 3.5 3 0 0 3 3 3 1 CoA binding domain CoA_binding PF02629.19 AIF83124.1 - 7.9e-12 45.7 2.4 1.6e-11 44.7 0.6 2.4 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_2 PF08442.10 AIF83124.1 - 3.8e-06 26.6 0.2 8e-06 25.6 0.2 1.6 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 AIF83124.1 - 0.0022 17.5 0.1 0.0044 16.5 0.1 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain YIEGIA PF14045.6 AIF83124.1 - 0.029 13.2 0.0 0.055 12.3 0.0 1.4 1 0 0 1 1 1 0 YIEGIA protein HMD PF03201.16 AIF83124.1 - 0.031 14.5 0.0 0.16 12.2 0.0 2.2 1 0 0 1 1 1 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Pan3_PK PF18101.1 AIF83124.1 - 0.034 14.1 0.1 0.078 13.0 0.1 1.5 1 0 0 1 1 1 0 Pan3 Pseudokinase domain HATPase_c PF02518.26 AIF83125.1 - 2.1e-24 86.2 0.1 5.2e-24 84.9 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIF83125.1 - 2.6e-15 56.2 1.0 7.6e-15 54.7 1.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 AIF83125.1 - 0.0017 18.3 0.0 0.0046 16.9 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain DUF4070 PF13282.6 AIF83125.1 - 0.037 14.2 0.1 0.13 12.3 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4070) Snapin_Pallidin PF14712.6 AIF83125.1 - 0.33 11.4 5.3 3.2 8.2 0.1 3.4 3 1 0 3 3 3 0 Snapin/Pallidin Spore_III_AB PF09548.10 AIF83125.1 - 0.89 9.6 10.5 0.42 10.7 3.1 3.1 3 0 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) Acetyltransf_1 PF00583.25 AIF83126.1 - 1.4e-14 54.4 0.0 1.7e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AIF83126.1 - 9.6e-10 38.5 0.0 5.5e-09 36.0 0.0 1.8 1 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AIF83126.1 - 1.9e-09 37.8 0.0 3.3e-09 37.1 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AIF83126.1 - 1.6e-07 31.2 0.0 2.5e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 AIF83126.1 - 4.3e-06 26.8 0.1 7.9e-06 26.0 0.1 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 AIF83126.1 - 0.0012 18.5 0.0 0.0018 18.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 AIF83126.1 - 0.0055 16.8 0.0 0.0099 16.0 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase PanZ PF12568.8 AIF83126.1 - 0.053 13.3 0.0 0.061 13.0 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ zinc_ribbon_2 PF13240.6 AIF83127.1 - 7.1e-08 31.9 5.4 7.1e-08 31.9 5.4 3.1 3 0 0 3 3 3 1 zinc-ribbon domain DZR PF12773.7 AIF83127.1 - 9.8e-08 31.9 7.2 4.1e-05 23.5 2.0 2.3 2 0 0 2 2 2 2 Double zinc ribbon zf-ribbon_3 PF13248.6 AIF83127.1 - 0.00045 19.5 3.4 0.00045 19.5 3.4 2.9 3 0 0 3 3 3 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 AIF83127.1 - 0.00051 20.7 2.5 0.061 14.1 0.1 2.4 2 1 0 2 2 2 1 zinc-ribbon family zinc-ribbons_6 PF07191.12 AIF83127.1 - 0.00052 20.0 1.0 2.5 8.1 0.1 3.2 3 0 0 3 3 3 1 zinc-ribbons PRC PF05239.16 AIF83127.1 - 0.0019 18.2 0.6 0.0032 17.5 0.6 1.4 1 0 0 1 1 1 1 PRC-barrel domain zf-RanBP PF00641.18 AIF83127.1 - 0.0055 16.0 1.2 0.0055 16.0 1.2 2.5 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others DUF2158 PF09926.9 AIF83127.1 - 0.019 14.7 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized small protein (DUF2158) HupF_HypC PF01455.18 AIF83127.1 - 0.11 12.7 0.3 1.8 8.8 0.1 2.4 2 0 0 2 2 2 0 HupF/HypC family Zn-ribbon_8 PF09723.10 AIF83127.1 - 0.15 12.2 15.5 2.3 8.4 0.1 4.1 3 1 1 4 4 4 0 Zinc ribbon domain DUF2757 PF10955.8 AIF83127.1 - 0.18 12.1 2.9 12 6.2 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2757) OrfB_Zn_ribbon PF07282.11 AIF83127.1 - 0.47 10.4 5.6 0.43 10.5 0.4 2.6 3 0 0 3 3 3 0 Putative transposase DNA-binding domain HypA PF01155.19 AIF83127.1 - 0.67 10.0 6.9 5.6 7.0 0.9 2.6 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-B_box PF00643.24 AIF83127.1 - 0.72 10.1 8.0 2.3 8.4 0.4 2.8 3 0 0 3 3 3 0 B-box zinc finger Ephrin_rec_like PF07699.13 AIF83127.1 - 1 9.1 10.4 0.25 11.2 3.0 2.8 3 0 0 3 3 3 0 Putative ephrin-receptor like Prok-RING_1 PF14446.6 AIF83127.1 - 10 6.2 9.2 2.9 7.9 1.1 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 ABC2_membrane PF01061.24 AIF83128.1 - 3.2e-23 82.3 23.5 5e-23 81.6 23.5 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 AIF83128.1 - 7.3e-13 48.3 34.8 8.8e-13 48.1 24.3 2.0 1 1 1 2 2 2 2 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 AIF83128.1 - 4.5e-05 22.9 20.4 0.0001 21.7 20.4 1.7 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 AIF83128.1 - 0.00019 21.4 12.4 0.00074 19.5 12.4 2.0 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_5 PF13346.6 AIF83128.1 - 0.0027 17.3 24.8 0.022 14.3 22.9 2.4 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 AIF83129.1 - 1.8e-30 106.3 0.0 3.6e-30 105.3 0.0 1.5 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 AIF83129.1 - 2.4e-12 47.3 0.4 4.7e-07 29.9 0.1 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 AIF83129.1 - 9.4e-06 26.3 0.0 2.7e-05 24.8 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_23 PF13476.6 AIF83129.1 - 0.00054 20.5 0.0 0.00081 19.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AIF83129.1 - 0.01 15.5 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 AIF83129.1 - 0.015 15.0 0.0 2.2 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 AIF83129.1 - 0.024 14.3 0.0 0.05 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP54 PF00448.22 AIF83129.1 - 0.026 14.2 0.1 0.054 13.1 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Rad17 PF03215.15 AIF83129.1 - 0.058 13.3 0.2 0.57 10.1 0.2 2.1 1 1 0 1 1 1 0 Rad17 P-loop domain SbcCD_C PF13558.6 AIF83129.1 - 0.1 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA PF00004.29 AIF83129.1 - 0.13 12.7 0.2 0.44 11.0 0.1 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) tRNA_anti-codon PF01336.25 AIF83130.1 - 2.1e-14 53.3 1.5 0.0002 21.2 0.0 3.6 3 0 0 3 3 3 3 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 AIF83130.1 - 1.7e-05 24.7 0.0 0.025 14.3 0.0 2.3 2 0 0 2 2 2 2 Cell division control protein 24, OB domain 3 REPA_OB_2 PF16900.5 AIF83130.1 - 0.0019 18.0 3.9 0.015 15.2 0.0 3.0 3 0 0 3 3 3 1 Replication protein A OB domain POT1PC PF16686.5 AIF83130.1 - 0.004 17.1 0.0 13 5.7 0.0 3.2 3 0 0 3 3 3 2 ssDNA-binding domain of telomere protection protein tRNA_anti_2 PF13742.6 AIF83130.1 - 0.062 13.5 0.2 30 4.9 0.0 3.5 3 0 0 3 3 3 0 OB-fold nucleic acid binding domain NfeD PF01957.18 AIF83130.1 - 0.072 13.5 2.6 2.3 8.6 0.1 3.2 3 1 1 4 4 4 0 NfeD-like C-terminal, partner-binding GCS2 PF04107.13 AIF83131.1 - 1.3e-06 27.9 0.0 3.4e-06 26.6 0.0 1.7 1 1 0 1 1 1 1 Glutamate-cysteine ligase family 2(GCS2) DEAD PF00270.29 AIF83132.1 - 7.8e-31 107.2 0.1 1.8e-30 106.0 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_assoc PF08494.11 AIF83132.1 - 3.7e-27 95.4 0.0 9.5e-27 94.0 0.0 1.8 1 0 0 1 1 1 1 DEAD/H associated Helicase_C PF00271.31 AIF83132.1 - 2.4e-24 85.8 0.1 6.9e-22 77.9 0.1 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AIF83132.1 - 6.1e-09 36.1 0.0 1.3e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 AIF83132.1 - 0.0003 19.6 0.0 0.0037 16.1 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Zn-ribbon_8 PF09723.10 AIF83132.1 - 0.009 16.1 0.5 0.02 15.0 0.5 1.5 1 0 0 1 1 1 1 Zinc ribbon domain HypA PF01155.19 AIF83132.1 - 0.013 15.5 0.1 0.036 14.1 0.1 1.8 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cas_APE2256 PF09651.10 AIF83132.1 - 0.02 14.8 0.3 2.4 8.1 0.0 3.5 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_APE2256) DUF4428 PF14471.6 AIF83132.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) TackOD1 PF18551.1 AIF83132.1 - 0.17 11.5 0.1 0.33 10.6 0.1 1.3 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 NCE101 PF11654.8 AIF83133.1 - 0.016 14.9 0.1 0.41 10.4 0.1 2.1 1 1 0 1 1 1 0 Non-classical export protein 1 MRAP PF15183.6 AIF83133.1 - 0.021 14.7 0.0 0.024 14.5 0.0 1.1 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family AIF_C PF14721.6 AIF83133.1 - 0.058 13.8 0.1 0.061 13.7 0.1 1.0 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAA_hydrolase_N PF09298.11 AIF83133.1 - 0.059 13.5 0.0 0.067 13.4 0.0 1.1 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal DUF4083 PF13314.6 AIF83133.1 - 0.15 12.0 0.0 0.22 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) KORA PF16509.5 AIF83134.1 - 0.024 14.9 1.4 1.8 8.9 0.0 3.5 3 0 0 3 3 3 0 TrfB plasmid transcriptional repressor Phage_r1t_holin PF16945.5 AIF83135.1 - 0.036 14.2 2.1 5 7.4 0.0 2.6 3 0 0 3 3 3 0 Putative lactococcus lactis phage r1t holin Phage_holin_3_1 PF05106.12 AIF83135.1 - 4.7 7.7 7.2 0.46 10.9 0.5 2.4 2 1 1 3 3 3 0 Phage holin family (Lysis protein S) Presenilin PF01080.17 AIF83135.1 - 8.9 5.0 8.8 0.54 9.0 4.0 1.4 2 0 0 2 2 2 0 Presenilin Fzo_mitofusin PF04799.13 AIF83136.1 - 0.011 15.4 1.1 0.015 14.9 1.1 1.2 1 0 0 1 1 1 0 fzo-like conserved region SOP4 PF17081.5 AIF83137.1 - 0.0033 17.0 0.1 0.004 16.7 0.1 1.1 1 0 0 1 1 1 1 Suppressor of PMA 1-7 protein TrmB PF01978.19 AIF83137.1 - 0.031 14.2 0.1 0.05 13.5 0.1 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 AIF83137.1 - 0.14 12.3 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain DUF326 PF03860.16 AIF83139.1 - 1.2e-07 31.4 60.5 0.0045 16.9 7.8 4.3 4 0 0 4 4 4 4 Domain of Unknown Function (DUF326) zf-C2H2 PF00096.26 AIF83140.1 - 4.7e-05 23.6 0.9 5.9e-05 23.3 0.9 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF83140.1 - 0.0009 19.9 0.4 0.0011 19.6 0.4 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_5 PF13909.6 AIF83140.1 - 1.3 8.8 4.6 2.5 7.9 4.6 1.5 1 1 0 1 1 1 0 C2H2-type zinc-finger domain Gram_pos_anchor PF00746.21 AIF83141.1 - 0.034 14.1 2.3 0.22 11.5 0.0 2.2 2 0 0 2 2 2 0 LPXTG cell wall anchor motif LEA_2 PF03168.13 AIF83142.1 - 0.028 15.0 0.0 0.048 14.2 0.0 1.5 1 1 0 1 1 1 0 Late embryogenesis abundant protein DUF1002 PF06207.11 AIF83142.1 - 0.051 13.1 0.1 0.073 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) GH114_assoc PF14741.6 AIF83143.1 - 0.057 13.6 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 N-terminal glycosyl-hydrolase-114-associated domain TrmB PF01978.19 AIF83144.1 - 1.1e-16 60.4 0.3 3.2e-16 59.0 0.1 1.9 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Penicillinase_R PF03965.16 AIF83144.1 - 0.015 15.6 0.0 0.035 14.5 0.0 1.7 1 1 0 1 1 1 0 Penicillinase repressor FUR PF01475.19 AIF83144.1 - 0.029 14.5 0.1 0.13 12.4 0.0 2.0 2 0 0 2 2 2 0 Ferric uptake regulator family PadR PF03551.14 AIF83144.1 - 0.044 13.8 0.0 0.17 11.8 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family MarR_2 PF12802.7 AIF83144.1 - 0.047 13.6 0.1 0.13 12.2 0.0 1.7 2 0 0 2 2 2 0 MarR family HTH_29 PF13551.6 AIF83144.1 - 0.12 12.4 0.0 0.42 10.7 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn helix Aldo_ket_red PF00248.21 AIF83145.1 - 6.3e-57 193.0 0.0 7.2e-57 192.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family tRNA-synt_1b PF00579.25 AIF83148.1 - 3.1e-41 141.6 0.0 7.2e-41 140.4 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) DUF45 PF01863.17 AIF83149.1 - 1.1e-51 175.8 1.7 1.3e-51 175.6 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF45 WLM PF08325.10 AIF83149.1 - 0.00021 21.4 0.0 0.00051 20.2 0.0 1.6 1 0 0 1 1 1 1 WLM domain Peptidase_M57 PF12388.8 AIF83149.1 - 0.17 11.5 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase TP6A_N PF04406.14 AIF83153.1 - 4e-14 52.3 0.0 6.9e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Topo-VIb_trans PF09239.11 AIF83154.1 - 2.6e-34 118.4 0.1 9.7e-33 113.2 0.1 2.6 1 1 0 1 1 1 1 Topoisomerase VI B subunit, transducer HATPase_c PF02518.26 AIF83154.1 - 3.6e-10 40.3 0.0 2.2e-09 37.8 0.0 2.3 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AIF83154.1 - 1e-06 28.6 0.0 3.7e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3237 PF11578.8 AIF83155.1 - 0.08 12.8 0.0 0.083 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3237) Rod_cone_degen PF15201.6 AIF83155.1 - 0.091 12.9 0.0 0.15 12.2 0.0 1.4 2 0 0 2 2 2 0 Progressive rod-cone degeneration PQ-loop PF04193.14 AIF83156.1 - 2.2e-10 40.2 0.5 2.2e-10 40.2 0.5 1.6 2 0 0 2 2 2 1 PQ loop repeat MtN3_slv PF03083.16 AIF83156.1 - 7.3e-07 29.1 0.4 1e-06 28.7 0.4 1.3 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 AIF83156.1 - 0.0011 19.1 0.2 0.0017 18.4 0.2 1.4 1 0 0 1 1 1 1 Lipid A Biosynthesis N-terminal domain Oxidored_q2 PF00420.24 AIF83156.1 - 0.17 11.6 2.2 9.7 5.9 0.6 2.2 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DHO_dh PF01180.21 AIF83159.1 - 2.1e-36 125.6 0.0 2.6e-36 125.4 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 AIF83159.1 - 0.0058 16.1 0.0 0.009 15.4 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 AIF83159.1 - 0.042 12.9 0.0 0.07 12.1 0.0 1.3 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Radical_SAM PF04055.21 AIF83160.1 - 1.5e-08 35.2 0.0 3.2e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily DUF5060 PF16586.5 AIF83160.1 - 0.062 13.7 1.8 1.8 9.0 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5060) TrbH PF07283.11 AIF83161.1 - 0.0066 16.6 0.1 0.0077 16.4 0.1 1.1 1 0 0 1 1 1 1 Conjugal transfer protein TrbH Qua1 PF16274.5 AIF83161.1 - 0.16 11.8 0.1 0.16 11.8 0.1 1.8 2 0 0 2 2 2 0 Qua1 domain HD PF01966.22 AIF83162.1 - 5.6e-14 52.4 0.7 9.2e-14 51.7 0.7 1.3 1 0 0 1 1 1 1 HD domain MIOX PF05153.15 AIF83162.1 - 0.042 13.4 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 Myo-inositol oxygenase Monooxygenase_B PF04744.12 AIF83163.1 - 1.4e-13 50.5 0.1 2.7e-13 49.5 0.0 1.5 1 1 0 1 1 1 1 Monooxygenase subunit B protein Rad51 PF08423.11 AIF83164.1 - 4.5e-88 294.8 0.2 5.9e-88 294.4 0.2 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 AIF83164.1 - 4.6e-12 46.0 0.2 6.3e-12 45.5 0.2 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 AIF83164.1 - 7.6e-09 35.3 0.8 1.7e-08 34.1 0.8 1.6 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 AIF83164.1 - 2.6e-05 23.9 0.0 5.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 AIF83164.1 - 0.0017 18.9 0.1 0.0064 17.1 0.1 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain AAA_24 PF13479.6 AIF83164.1 - 0.0045 16.7 0.0 0.0077 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain Cdd1 PF11731.8 AIF83164.1 - 0.018 15.3 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 Pathogenicity locus AAA_22 PF13401.6 AIF83164.1 - 0.035 14.4 0.1 0.082 13.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain DNA_pol_lambd_f PF10391.9 AIF83164.1 - 0.14 12.0 0.0 0.71 9.7 0.0 2.2 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda Ribosomal_L21e PF01157.18 AIF83165.1 - 1.3e-19 69.9 1.7 1.5e-19 69.8 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L21e SH3_13 PF18335.1 AIF83165.1 - 0.012 15.4 0.1 0.034 14.0 0.1 1.8 1 1 1 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain RNA_pol_Rpb4 PF03874.16 AIF83166.1 - 6.6e-08 32.9 0.5 1.4e-07 31.8 0.5 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb4 Bse634I PF07832.11 AIF83166.1 - 0.00037 19.9 0.3 0.00041 19.8 0.3 1.0 1 0 0 1 1 1 1 Cfr10I/Bse634I restriction endonuclease DUF2624 PF11116.8 AIF83166.1 - 0.028 15.3 2.1 0.98 10.4 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2624) DUF1869 PF08956.10 AIF83166.1 - 0.072 13.0 0.7 4.5 7.3 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1869) DUF655 PF04919.12 AIF83167.1 - 4.4e-54 183.2 0.3 5e-54 183.0 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF655) HHH_6 PF14579.6 AIF83167.1 - 2.3e-05 24.5 0.0 4.5e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_3 PF12836.7 AIF83167.1 - 0.013 15.7 0.0 0.035 14.3 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Transposase_20 PF02371.16 AIF83167.1 - 0.063 13.6 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family RrnaAD PF00398.20 AIF83168.1 - 2.4e-39 135.0 0.0 2.9e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.14 AIF83168.1 - 1.2e-05 24.9 0.0 2.1e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 AIF83168.1 - 3.5e-05 24.4 0.1 8.6e-05 23.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF83168.1 - 0.00012 22.7 0.1 0.00049 20.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF83168.1 - 0.00018 21.3 0.0 0.00024 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF83168.1 - 0.029 14.2 0.0 0.074 12.9 0.0 1.6 1 1 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 AIF83169.1 - 4e-05 23.2 0.0 0.0001 21.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 AIF83169.1 - 0.0001 22.9 0.1 0.00025 21.7 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF83169.1 - 0.0033 18.0 0.1 0.0057 17.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF83169.1 - 0.029 15.1 0.2 0.062 14.0 0.2 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 AIF83169.1 - 0.036 13.9 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Iso_dh PF00180.20 AIF83170.1 - 8.9e-80 268.4 0.0 1.1e-79 268.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pox_TAA1 PF03295.14 AIF83170.1 - 0.11 12.4 0.0 0.88 9.5 0.0 2.2 2 0 0 2 2 2 0 Poxvirus trans-activator protein A1 C-terminal Glyco_hydro_26 PF02156.15 AIF83171.1 - 0.11 11.9 0.2 0.13 11.6 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 26 Metallophos PF00149.28 AIF83172.1 - 3.3e-17 63.7 0.3 8.7e-17 62.3 0.3 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AIF83172.1 - 3.8e-13 50.0 0.0 5.3e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MutL PF13941.6 AIF83172.1 - 0.049 12.2 0.0 0.073 11.7 0.0 1.2 1 0 0 1 1 1 0 MutL protein AmoC PF04896.12 AIF83173.1 - 7.3e-14 51.6 7.0 9.1e-14 51.3 7.0 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C RTA1 PF04479.13 AIF83173.1 - 0.0045 16.6 0.3 0.0075 15.9 0.3 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF2975 PF11188.8 AIF83173.1 - 0.55 10.1 4.3 0.15 12.0 0.5 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) zf-FLZ PF04570.14 AIF83174.1 - 0.033 13.7 7.6 0.039 13.4 7.6 1.1 1 0 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 CEBP_ZZ PF16366.5 AIF83174.1 - 0.035 14.4 9.3 0.034 14.4 9.3 1.1 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-AN1 PF01428.16 AIF83174.1 - 0.23 11.6 9.1 0.38 11.0 9.2 1.3 1 1 0 1 1 1 0 AN1-like Zinc finger C1_2 PF03107.16 AIF83174.1 - 0.25 11.7 11.0 1.1 9.7 11.0 1.8 1 1 0 1 1 1 0 C1 domain UPF1_Zn_bind PF09416.10 AIF83174.1 - 0.87 9.5 6.6 0.97 9.4 6.6 1.1 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) zf-HIT PF04438.16 AIF83174.1 - 0.92 9.4 9.6 1.5 8.7 9.6 1.5 1 1 0 1 1 1 0 HIT zinc finger zf-B_box PF00643.24 AIF83174.1 - 1.1 9.4 8.9 1.8 8.8 8.9 1.3 1 1 0 1 1 1 0 B-box zinc finger FtsX PF02687.21 AIF83175.1 - 2.8e-14 53.3 2.0 2.8e-14 53.3 2.0 3.1 3 1 0 3 3 3 1 FtsX-like permease family MacB_PCD PF12704.7 AIF83175.1 - 7.4e-14 52.6 2.5 7.4e-14 52.6 2.5 2.1 2 1 0 2 2 2 1 MacB-like periplasmic core domain PRA1 PF03208.19 AIF83175.1 - 1.9 8.1 5.8 0.38 10.4 1.7 1.8 2 0 0 2 2 2 0 PRA1 family protein NPCBM_assoc PF10633.9 AIF83176.1 - 4.9e-09 36.3 10.9 0.013 15.7 0.0 5.2 4 1 0 4 4 4 3 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF11 PF01345.18 AIF83176.1 - 2.6e-06 27.7 22.5 0.00018 21.7 5.2 4.7 5 1 0 5 5 5 2 Domain of unknown function DUF11 Protocadherin PF08374.11 AIF83176.1 - 4e-05 23.7 0.1 6.7e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Protocadherin CARDB PF07705.11 AIF83176.1 - 0.0043 17.3 8.6 0.27 11.5 0.3 3.6 2 2 1 3 3 3 2 CARDB Syndecan PF01034.20 AIF83176.1 - 0.026 14.4 0.1 0.068 13.1 0.1 1.6 1 0 0 1 1 1 0 Syndecan domain Glycophorin_A PF01102.18 AIF83176.1 - 0.027 14.7 0.0 0.084 13.1 0.0 1.8 1 0 0 1 1 1 0 Glycophorin A DUF4064 PF13273.6 AIF83176.1 - 0.04 14.2 0.0 0.14 12.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) CD99L2 PF12301.8 AIF83176.1 - 0.12 12.7 1.4 0.22 11.8 0.9 1.6 1 1 0 1 1 1 0 CD99 antigen like protein 2 RIFIN PF02009.16 AIF83176.1 - 0.22 11.4 0.2 0.37 10.6 0.2 1.3 1 0 0 1 1 1 0 Rifin DUF4232 PF14016.6 AIF83176.1 - 2.2 8.4 7.4 3.3 7.9 4.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4232) ABC_tran PF00005.27 AIF83177.1 - 7.8e-34 117.1 0.0 1.2e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIF83177.1 - 1.3e-08 35.0 0.8 0.0042 16.9 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIF83177.1 - 9.3e-08 31.8 0.3 3.6e-06 26.6 0.3 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AIF83177.1 - 3.1e-05 23.6 0.1 6.1e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 AIF83177.1 - 4.6e-05 23.3 0.1 0.046 13.4 0.1 2.1 2 0 0 2 2 2 2 AAA ATPase domain IstB_IS21 PF01695.17 AIF83177.1 - 0.00025 20.8 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 2 IstB-like ATP binding protein RsgA_GTPase PF03193.16 AIF83177.1 - 0.00031 20.7 0.1 0.00061 19.7 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 AIF83177.1 - 0.0006 20.2 0.0 0.001 19.5 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 AIF83177.1 - 0.0012 19.4 0.1 0.002 18.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AIF83177.1 - 0.0029 17.9 0.1 0.0097 16.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AIF83177.1 - 0.0053 16.5 0.1 0.01 15.6 0.1 1.7 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 AIF83177.1 - 0.0074 16.4 0.4 0.016 15.3 0.4 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 AIF83177.1 - 0.02 14.8 0.0 0.062 13.2 0.0 1.9 1 1 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 AIF83177.1 - 0.045 13.3 0.1 0.086 12.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AIF83177.1 - 0.058 13.6 0.1 0.29 11.3 0.1 2.0 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 AIF83177.1 - 0.059 12.4 0.1 0.096 11.7 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein G-alpha PF00503.20 AIF83177.1 - 0.059 12.5 0.0 0.068 12.3 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Dynamin_N PF00350.23 AIF83177.1 - 0.065 13.3 0.2 0.62 10.1 0.3 2.1 2 0 0 2 2 2 0 Dynamin family ATPase_2 PF01637.18 AIF83177.1 - 0.087 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 AIF83177.1 - 0.12 11.6 0.1 0.27 10.4 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.19 AIF83177.1 - 0.13 11.8 0.2 0.24 11.0 0.0 1.6 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 AIF83177.1 - 0.14 12.7 0.0 0.28 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 AIF83177.1 - 0.2 11.9 0.1 0.37 11.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain YHS PF04945.13 AIF83178.1 - 5.4e-13 48.8 0.9 6.4e-13 48.6 0.9 1.1 1 0 0 1 1 1 1 YHS domain Arc_trans_TRASH PF08394.10 AIF83178.1 - 1.9e-06 28.1 1.5 2.4e-06 27.8 1.5 1.1 1 0 0 1 1 1 1 Archaeal TRASH domain ATPase-cat_bd PF12156.8 AIF83178.1 - 9.1e-05 23.1 1.2 0.00011 22.8 1.2 1.0 1 0 0 1 1 1 1 Putative metal-binding domain of cation transport ATPase CAP_GLY PF01302.25 AIF83178.1 - 0.031 14.3 0.1 0.039 14.0 0.1 1.2 1 0 0 1 1 1 0 CAP-Gly domain Asn_synthase PF00733.21 AIF83179.1 - 6.2e-35 121.5 0.2 1.1e-21 77.9 0.0 2.0 1 1 1 2 2 2 2 Asparagine synthase ThiI PF02568.14 AIF83179.1 - 0.22 11.1 0.2 0.66 9.5 0.2 1.7 1 1 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Glyoxalase_4 PF13669.6 AIF83180.1 - 3.2e-23 82.1 0.0 4e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 AIF83180.1 - 5.5e-14 52.5 0.0 7.1e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 AIF83180.1 - 1.5e-08 34.9 0.0 1.8e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Fmp27_SW PF10305.9 AIF83180.1 - 0.054 14.2 0.0 0.13 13.0 0.0 1.6 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain MM_CoA_mutase PF01642.22 AIF83181.1 - 7.1e-224 744.1 0.2 8e-224 743.9 0.2 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase Ca_bind_SSO6904 PF18249.1 AIF83181.1 - 0.096 13.1 0.1 0.39 11.1 0.0 2.2 2 0 0 2 2 2 0 Calcium binding protein SSO6904 DUF3037 PF11236.8 AIF83181.1 - 0.3 11.5 1.2 2.7 8.4 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3037) MeaB PF03308.16 AIF83182.1 - 2.3e-81 272.7 4.0 2.8e-81 272.4 4.0 1.0 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 AIF83182.1 - 6.5e-06 26.1 0.0 0.0087 15.9 0.0 2.4 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 AIF83182.1 - 8.3e-05 22.6 0.0 0.0019 18.1 0.0 2.6 2 1 0 2 2 2 1 RsgA GTPase cobW PF02492.19 AIF83182.1 - 0.0025 17.4 0.4 0.014 15.0 0.4 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MnmE_helical PF12631.7 AIF83182.1 - 0.0027 17.9 0.0 0.0084 16.3 0.0 1.4 1 1 0 1 1 1 1 MnmE helical domain MobB PF03205.14 AIF83182.1 - 0.0037 17.2 0.0 0.056 13.3 0.0 2.3 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.27 AIF83182.1 - 0.0049 16.4 0.0 0.18 11.3 0.0 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CbiA PF01656.23 AIF83182.1 - 0.0076 16.3 0.0 0.016 15.2 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 AIF83182.1 - 0.016 15.3 0.2 0.12 12.5 0.0 2.5 2 1 1 3 3 2 0 50S ribosome-binding GTPase PIF1 PF05970.14 AIF83182.1 - 0.026 13.7 0.0 0.05 12.8 0.0 1.4 1 0 0 1 1 1 0 PIF1-like helicase AAA_16 PF13191.6 AIF83182.1 - 0.029 14.7 0.1 0.075 13.4 0.1 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 AIF83182.1 - 0.03 14.0 0.0 0.088 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AIF83182.1 - 0.077 13.5 0.4 0.19 12.3 0.1 1.9 2 0 0 2 2 2 0 ABC transporter Ribosomal_L20 PF00453.18 AIF83182.1 - 0.1 12.7 0.2 0.21 11.7 0.2 1.4 1 0 0 1 1 1 0 Ribosomal protein L20 AAA_5 PF07728.14 AIF83182.1 - 0.1 12.6 0.3 3.1 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Glyco_trans_4_4 PF13579.6 AIF83182.1 - 0.14 12.6 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain ArsA_ATPase PF02374.15 AIF83182.1 - 0.15 11.2 2.6 0.42 9.7 0.4 2.3 2 0 0 2 2 2 0 Anion-transporting ATPase Cas_Cas02710 PF09670.10 AIF83183.1 - 0.00029 19.7 0.9 0.00031 19.7 0.9 1.0 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Cas02710) Herpes_UL6 PF01763.16 AIF83183.1 - 0.016 13.7 0.6 0.018 13.6 0.6 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like DUF3919 PF13057.6 AIF83183.1 - 0.034 13.7 2.1 0.042 13.4 2.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) DUF764 PF05561.11 AIF83183.1 - 0.037 13.8 0.1 0.043 13.6 0.1 1.2 1 1 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF764) B12-binding PF02310.19 AIF83184.1 - 2e-19 69.8 0.1 2.6e-19 69.4 0.1 1.1 1 0 0 1 1 1 1 B12 binding domain IlvN PF07991.12 AIF83185.1 - 9.9e-70 233.4 0.9 1.4e-69 232.9 0.9 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 AIF83185.1 - 9.4e-59 197.8 1.0 1.5e-58 197.1 1.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain 2-Hacid_dh_C PF02826.19 AIF83185.1 - 5.7e-07 29.1 0.1 9.7e-07 28.3 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 AIF83185.1 - 7.9e-07 29.4 0.3 1.6e-06 28.4 0.3 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 AIF83185.1 - 1.7e-05 25.3 0.7 4.2e-05 24.1 0.7 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 AIF83185.1 - 0.0045 17.1 0.2 0.0082 16.2 0.2 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain tRNA_SAD PF07973.14 AIF83185.1 - 0.18 12.0 0.1 0.43 10.7 0.1 1.6 1 0 0 1 1 1 0 Threonyl and Alanyl tRNA synthetase second additional domain Usp PF00582.26 AIF83186.1 - 2.3e-29 102.7 0.1 2.6e-29 102.5 0.1 1.0 1 0 0 1 1 1 1 Universal stress protein family Yip1 PF04893.17 AIF83189.1 - 0.0018 18.0 22.7 0.0027 17.5 22.7 1.3 1 0 0 1 1 1 1 Yip1 domain Peptidase_U4 PF03419.13 AIF83189.1 - 0.0038 16.5 14.0 0.0055 16.0 14.0 1.2 1 0 0 1 1 1 1 Sporulation factor SpoIIGA Vma12 PF11712.8 AIF83189.1 - 1.3 9.1 7.3 2.4 8.2 7.3 1.6 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase ECF_trnsprt PF12822.7 AIF83189.1 - 1.9 8.5 20.0 2.7 8.1 20.0 1.2 1 0 0 1 1 1 0 ECF transporter, substrate-specific component DUF4229 PF14012.6 AIF83189.1 - 4.3 7.5 14.3 0.7 10.0 1.5 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF4229) HisKA_3 PF07730.13 AIF83190.1 - 2.9e-06 27.7 3.7 0.00072 20.0 0.1 3.3 2 1 1 3 3 3 1 Histidine kinase Laminin_II PF06009.12 AIF83190.1 - 5.8e-05 23.1 7.0 0.01 15.9 0.9 2.2 2 0 0 2 2 2 2 Laminin Domain II ApoLp-III PF07464.11 AIF83190.1 - 0.00024 21.2 11.1 0.0043 17.2 9.4 2.4 1 1 1 2 2 2 2 Apolipophorin-III precursor (apoLp-III) YtxH PF12732.7 AIF83190.1 - 0.0005 20.5 11.2 9.9 6.8 11.2 3.1 1 1 0 1 1 1 0 YtxH-like protein DUF883 PF05957.13 AIF83190.1 - 0.002 18.7 6.7 0.12 13.0 1.6 2.3 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF883) TMP_2 PF06791.13 AIF83190.1 - 0.0057 16.3 7.7 0.042 13.5 1.0 2.1 1 1 1 2 2 2 1 Prophage tail length tape measure protein DUF948 PF06103.11 AIF83190.1 - 0.0058 16.9 6.9 0.94 9.8 3.5 2.5 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF948) PhageMin_Tail PF10145.9 AIF83190.1 - 0.0097 15.8 6.2 0.33 10.8 6.2 2.1 1 1 0 1 1 1 1 Phage-related minor tail protein DUF1296 PF06972.11 AIF83190.1 - 0.015 15.4 0.9 3.4 7.9 0.0 3.7 1 1 2 4 4 4 0 Protein of unknown function (DUF1296) Laminin_I PF06008.14 AIF83190.1 - 0.016 15.0 6.2 0.34 10.6 1.3 2.6 1 1 1 2 2 2 0 Laminin Domain I SseC PF04888.12 AIF83190.1 - 0.018 14.7 7.5 0.023 14.3 7.5 1.0 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family BLOC1_2 PF10046.9 AIF83190.1 - 0.018 15.3 5.1 0.063 13.6 0.5 2.8 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Rab5-bind PF09311.11 AIF83190.1 - 0.02 14.3 0.4 0.02 14.3 0.4 1.9 1 1 0 1 1 1 0 Rabaptin-like protein KxDL PF10241.9 AIF83190.1 - 0.027 14.7 5.0 0.097 13.0 1.3 2.7 2 1 0 2 2 2 0 Uncharacterized conserved protein DUF1664 PF07889.12 AIF83190.1 - 0.031 14.3 6.3 0.15 12.1 2.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) MukF_M PF17192.4 AIF83190.1 - 0.035 13.9 2.2 2.6 7.8 0.2 2.1 1 1 1 2 2 2 0 MukF middle domain WXG100 PF06013.12 AIF83190.1 - 0.042 14.1 5.3 30 5.0 0.0 3.9 2 1 1 3 3 3 0 Proteins of 100 residues with WXG TPR_MLP1_2 PF07926.12 AIF83190.1 - 0.044 13.9 8.1 0.25 11.4 7.3 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein EzrA PF06160.12 AIF83190.1 - 0.078 11.2 5.4 0.12 10.6 5.4 1.3 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Apolipoprotein PF01442.18 AIF83190.1 - 0.082 12.8 7.4 0.19 11.6 7.4 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Phage_sheath_1C PF17482.2 AIF83190.1 - 0.092 12.7 0.8 0.22 11.5 0.8 1.8 1 1 0 1 1 1 0 Phage tail sheath C-terminal domain DLP_helical PF18709.1 AIF83190.1 - 0.099 11.8 8.2 0.14 11.4 2.3 2.2 1 1 0 2 2 2 0 Dynamin-like helical domain ECM11 PF15463.6 AIF83190.1 - 0.1 13.1 3.0 0.9 10.1 0.3 2.4 2 1 0 2 2 2 0 Extracellular mutant protein 11 LXG PF04740.12 AIF83190.1 - 0.13 12.0 5.2 0.1 12.3 2.4 1.9 1 1 1 2 2 2 0 LXG domain of WXG superfamily Prominin PF05478.11 AIF83190.1 - 0.14 10.0 4.9 0.46 8.4 5.0 1.5 1 1 0 1 1 1 0 Prominin RmuC PF02646.16 AIF83190.1 - 0.16 11.1 5.9 0.26 10.4 0.7 2.5 1 1 1 2 2 2 0 RmuC family Syntaxin-6_N PF09177.11 AIF83190.1 - 0.16 12.5 6.5 1.2 9.7 0.4 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF2250 PF10007.9 AIF83190.1 - 0.16 12.1 0.9 3 8.0 0.0 2.5 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2250) DUF4208 PF13907.6 AIF83190.1 - 0.17 12.3 1.4 0.5 10.8 0.4 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4208) Spc7 PF08317.11 AIF83190.1 - 0.22 10.4 8.9 0.078 11.8 3.7 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein PqqD PF05402.12 AIF83190.1 - 0.24 11.7 1.3 13 6.2 0.2 3.1 2 1 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) MAD PF05557.13 AIF83190.1 - 0.28 9.5 7.0 0.31 9.3 7.0 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Sec8_exocyst PF04048.14 AIF83190.1 - 0.28 11.0 3.7 1.8 8.5 0.9 2.4 1 1 2 3 3 3 0 Sec8 exocyst complex component specific domain RRF PF01765.19 AIF83190.1 - 0.29 11.1 10.3 1.2 9.1 1.8 2.4 1 1 2 3 3 3 0 Ribosome recycling factor HAUS-augmin3 PF14932.6 AIF83190.1 - 0.34 10.5 3.8 0.41 10.2 3.2 1.4 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF2203 PF09969.9 AIF83190.1 - 0.35 11.6 6.9 1.3 9.7 2.4 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) TMPIT PF07851.13 AIF83190.1 - 0.37 10.0 6.6 0.46 9.7 2.8 2.0 1 1 0 2 2 2 0 TMPIT-like protein Mobilization_B PF17511.2 AIF83190.1 - 0.41 11.0 5.5 2.1 8.7 2.9 2.2 1 1 1 2 2 2 0 Mobilization protein B Med30 PF11315.8 AIF83190.1 - 0.44 10.7 3.0 8.1 6.6 0.1 2.5 1 1 0 2 2 2 0 Mediator complex subunit 30 RasGAP_C PF03836.15 AIF83190.1 - 0.53 10.4 4.8 0.61 10.2 2.9 2.1 1 1 1 2 2 2 0 RasGAP C-terminus FlaC_arch PF05377.11 AIF83190.1 - 0.76 10.2 5.9 4.5 7.7 0.1 3.4 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) Spectrin PF00435.21 AIF83190.1 - 0.85 10.1 4.2 6 7.4 1.7 2.5 1 1 2 3 3 3 0 Spectrin repeat Cauli_DNA-bind PF03310.13 AIF83190.1 - 0.96 9.5 5.7 0.51 10.4 2.5 1.9 1 1 1 2 2 2 0 Caulimovirus DNA-binding protein Lectin_N PF03954.14 AIF83190.1 - 1 9.1 3.1 11 5.8 3.1 2.1 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain OmpH PF03938.14 AIF83190.1 - 1.7 9.0 10.3 0.85 10.0 2.9 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) UPF0242 PF06785.11 AIF83190.1 - 1.7 8.7 5.3 4.7 7.3 5.2 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus LMBR1 PF04791.16 AIF83190.1 - 2.1 7.1 4.9 2.6 6.8 1.4 1.8 1 1 1 2 2 2 0 LMBR1-like membrane protein DUF5301 PF17225.3 AIF83190.1 - 2.4 8.7 9.0 6.7 7.2 0.3 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF5300) Uso1_p115_C PF04871.13 AIF83190.1 - 4.1 7.8 12.4 1.2e+02 3.0 0.2 2.7 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Seryl_tRNA_N PF02403.22 AIF83190.1 - 6.3 7.1 10.4 12 6.2 6.7 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3470 PF11953.8 AIF83191.1 - 0.088 12.8 1.4 0.53 10.3 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3470) ADK_lid PF05191.14 AIF83192.1 - 0.0038 17.2 1.2 0.0098 15.9 1.2 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid HTH_5 PF01022.20 AIF83193.1 - 2.1e-13 49.9 0.4 5.5e-13 48.6 0.4 1.7 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIF83193.1 - 2.1e-12 46.9 0.4 4.8e-12 45.8 0.4 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 AIF83193.1 - 5.8e-08 32.5 0.3 1.4e-07 31.2 0.1 1.8 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.6 AIF83193.1 - 3.4e-07 29.7 0.7 8.9e-07 28.4 0.1 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.6 AIF83193.1 - 4.1e-05 23.5 0.3 0.00011 22.1 0.3 1.8 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_11 PF08279.12 AIF83193.1 - 4.4e-05 23.3 0.3 0.00011 22.1 0.3 1.6 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 AIF83193.1 - 0.00011 22.1 1.5 0.00038 20.3 0.4 2.2 2 0 0 2 2 2 1 MarR family Sigma70_r4 PF04545.16 AIF83193.1 - 0.0016 17.9 0.1 0.0081 15.7 0.0 2.0 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_IclR PF09339.10 AIF83193.1 - 0.0017 18.1 0.3 0.0038 17.0 0.3 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain TFIIE_alpha PF02002.17 AIF83193.1 - 0.0018 18.1 0.1 0.0039 17.0 0.1 1.5 1 0 0 1 1 1 1 TFIIE alpha subunit HTH_Tnp_ISL3 PF13542.6 AIF83193.1 - 0.0033 16.8 0.2 0.0079 15.6 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 HTH_10 PF04967.12 AIF83193.1 - 0.0062 16.3 0.1 0.012 15.4 0.1 1.4 1 0 0 1 1 1 1 HTH DNA binding domain TrmB PF01978.19 AIF83193.1 - 0.0062 16.4 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Rrf2 PF02082.20 AIF83193.1 - 0.0088 16.4 0.2 0.021 15.1 0.2 1.6 1 0 0 1 1 1 1 Transcriptional regulator HTH_26 PF13443.6 AIF83193.1 - 0.01 16.2 0.2 0.024 15.1 0.2 1.6 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain HTH_3 PF01381.22 AIF83193.1 - 0.023 14.7 0.1 0.056 13.5 0.0 1.7 2 0 0 2 2 1 0 Helix-turn-helix HTH_34 PF13601.6 AIF83193.1 - 0.037 14.2 0.1 0.093 12.9 0.1 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain DprA_WH PF17782.1 AIF83193.1 - 0.048 13.8 0.2 0.08 13.1 0.2 1.3 1 0 0 1 1 1 0 DprA winged helix domain Mga PF05043.13 AIF83193.1 - 0.049 14.2 0.2 0.21 12.2 0.0 2.1 2 0 0 2 2 1 0 Mga helix-turn-helix domain Phage_rep_O PF04492.13 AIF83193.1 - 0.051 14.2 0.1 0.12 13.0 0.1 1.6 1 0 0 1 1 1 0 Bacteriophage replication protein O HTH_9 PF08221.11 AIF83193.1 - 0.08 13.1 0.4 0.21 11.7 0.4 1.8 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain ArsR PF09824.9 AIF83193.1 - 0.09 12.4 0.8 0.12 11.9 0.1 1.7 2 1 0 2 2 2 0 ArsR transcriptional regulator Replic_Relax PF13814.6 AIF83193.1 - 0.14 12.2 0.2 0.22 11.5 0.2 1.3 1 0 0 1 1 1 0 Replication-relaxation HTH_35 PF13693.6 AIF83193.1 - 0.21 11.7 1.1 0.31 11.1 0.1 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Prominin PF05478.11 AIF83194.1 - 0.0077 14.2 5.0 0.01 13.8 5.0 1.2 1 0 0 1 1 1 1 Prominin DUF2203 PF09969.9 AIF83194.1 - 0.0087 16.8 7.2 0.018 15.8 1.6 2.5 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2203) PMEI PF04043.15 AIF83194.1 - 0.012 15.9 0.7 0.017 15.4 0.7 1.3 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor DUF3829 PF12889.7 AIF83194.1 - 0.014 14.9 3.7 0.22 11.0 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) UPF0242 PF06785.11 AIF83194.1 - 0.027 14.6 2.8 0.041 14.0 2.8 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus NOG1_N PF17835.1 AIF83194.1 - 0.039 13.9 3.2 0.23 11.4 0.5 2.3 1 1 1 2 2 2 0 NOG1 N-terminal helical domain CorA PF01544.18 AIF83194.1 - 0.052 12.9 1.2 0.082 12.2 0.6 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein HisKA_3 PF07730.13 AIF83194.1 - 0.053 14.0 3.5 20 5.8 0.0 4.0 1 1 2 3 3 3 0 Histidine kinase Halogen_Hydrol PF10112.9 AIF83194.1 - 0.056 13.5 5.4 1.7 8.6 0.3 2.9 1 1 1 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Peptidase_S66C PF17676.1 AIF83194.1 - 0.065 13.8 0.2 0.17 12.4 0.2 1.8 1 1 0 1 1 1 0 LD-carboxypeptidase C-terminal domain DUF3546 PF12066.8 AIF83194.1 - 0.072 13.3 1.1 0.21 11.8 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3546) Rh5 PF18515.1 AIF83194.1 - 0.091 12.0 3.9 0.092 12.0 1.1 2.0 1 1 2 3 3 3 0 Rh5 coiled-coil domain Syntaxin_2 PF14523.6 AIF83194.1 - 0.1 12.9 9.3 2 8.8 1.6 3.3 1 1 1 2 2 2 0 Syntaxin-like protein DUF4400 PF14348.6 AIF83194.1 - 0.11 12.0 2.2 0.15 11.6 1.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4400) Syntaxin-6_N PF09177.11 AIF83194.1 - 0.12 12.9 6.5 0.81 10.3 4.8 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal FlgN PF05130.12 AIF83194.1 - 0.17 12.4 3.7 1.5 9.3 3.7 2.2 1 1 0 1 1 1 0 FlgN protein DUF4194 PF13835.6 AIF83194.1 - 0.19 11.5 3.3 0.27 11.0 0.4 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4194) WXG100 PF06013.12 AIF83194.1 - 0.27 11.5 5.0 4 7.8 2.6 3.2 2 1 1 3 3 2 0 Proteins of 100 residues with WXG BURP PF03181.15 AIF83194.1 - 0.27 10.8 3.3 0.53 9.8 3.3 1.5 1 1 0 1 1 1 0 BURP domain YtxH PF12732.7 AIF83194.1 - 0.37 11.3 9.8 6.3e+02 1.0 9.8 3.4 1 1 0 1 1 1 0 YtxH-like protein F_actin_bind PF08919.10 AIF83194.1 - 0.39 10.8 5.5 2.5 8.2 3.0 2.9 1 1 2 3 3 3 0 F-actin binding MAT1 PF06391.13 AIF83194.1 - 0.64 9.8 8.9 2.9 7.7 8.5 1.9 1 1 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 BORCS8 PF10167.9 AIF83194.1 - 0.95 9.4 7.0 0.39 10.7 1.5 2.4 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 8 Muted PF14942.6 AIF83194.1 - 1.4 9.3 7.9 1.5 9.2 5.7 1.9 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Fib_alpha PF08702.10 AIF83194.1 - 2.2 8.5 11.0 8.8 6.5 1.3 2.7 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF1296 PF06972.11 AIF83194.1 - 2.6 8.3 8.6 6.3 7.0 0.7 3.6 2 2 1 3 3 3 0 Protein of unknown function (DUF1296) DUF4094 PF13334.6 AIF83194.1 - 5.8 7.4 6.9 4.2e+02 1.4 6.8 3.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) Allexi_40kDa PF05549.11 AIF83194.1 - 7.6 6.0 6.7 5.1 6.5 2.1 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein Ferritin PF00210.24 AIF83195.1 - 1e-29 103.3 0.2 1.3e-29 103.0 0.2 1.0 1 0 0 1 1 1 1 Ferritin-like domain HrpB2 PF09487.10 AIF83195.1 - 0.03 14.7 0.1 0.061 13.8 0.0 1.5 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB2) Spermine_synth PF01564.17 AIF83196.1 - 8.1e-08 31.9 0.0 1.5e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_25 PF13649.6 AIF83196.1 - 0.049 14.3 0.0 0.13 12.9 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Afaf PF15339.6 AIF83196.1 - 1.7 8.4 3.9 3.6 7.3 0.4 2.3 2 0 0 2 2 2 0 Acrosome formation-associated factor PLDc_2 PF13091.6 AIF83197.1 - 0.00043 20.2 0.9 0.056 13.3 0.2 2.4 2 0 0 2 2 2 2 PLD-like domain CbiJ PF02571.14 AIF83197.1 - 0.0072 15.8 0.4 0.38 10.2 0.1 2.8 3 0 0 3 3 3 1 Precorrin-6x reductase CbiJ/CobK DUF4242 PF14026.6 AIF83198.1 - 3.4e-10 40.0 0.0 4.9e-10 39.5 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4242) DUF1831 PF08866.10 AIF83198.1 - 0.21 12.1 0.0 0.29 11.6 0.0 1.2 1 0 0 1 1 1 0 Putative amino acid metabolism DUF2795 PF11387.8 AIF83199.1 - 0.00034 20.8 0.0 0.00077 19.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2795) zf-C2H2 PF00096.26 AIF83199.1 - 0.00065 20.0 1.6 0.0012 19.1 0.8 2.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 AIF83199.1 - 0.0044 17.0 0.4 0.0076 16.2 0.4 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 AIF83199.1 - 0.014 16.1 0.4 0.014 16.1 0.4 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf_UBZ PF18439.1 AIF83199.1 - 0.058 13.0 0.2 0.11 12.1 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 AIF83199.1 - 0.068 13.5 2.0 0.14 12.5 2.0 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 AIF83199.1 - 0.095 12.6 0.3 0.16 11.9 0.3 1.3 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf_ZIC PF18366.1 AIF83199.1 - 0.13 12.4 0.1 0.31 11.2 0.1 1.6 1 0 0 1 1 1 0 Zic proteins zinc finger domain Putative_PNPOx PF01243.20 AIF83201.1 - 2.2e-13 50.2 0.0 4.4e-13 49.2 0.0 1.4 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIF83201.1 - 8.7e-06 25.4 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Arm-DNA-bind_2 PF12167.8 AIF83201.1 - 0.044 13.7 0.6 0.15 12.0 0.1 2.0 2 0 0 2 2 2 0 Arm DNA-binding domain Rieske PF00355.26 AIF83202.1 - 1.7e-15 56.7 0.0 2e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIF83202.1 - 9.9e-06 25.4 0.0 1.2e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain MazE_antitoxin PF04014.18 AIF83202.1 - 0.022 14.7 0.3 0.039 13.9 0.3 1.3 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin Acetyltransf_1 PF00583.25 AIF83203.1 - 4.7e-11 42.9 0.0 6.5e-11 42.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AIF83203.1 - 3.2e-10 40.3 0.0 5e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AIF83203.1 - 1.8e-09 37.6 0.0 2.7e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AIF83203.1 - 3e-05 24.1 0.0 0.00012 22.2 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AIF83203.1 - 0.00058 19.8 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 AIF83203.1 - 0.025 14.7 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF1801 PF08818.11 AIF83204.1 - 1.8e-10 41.2 0.0 2.3e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DU1801) DUF668 PF05003.12 AIF83204.1 - 0.19 12.2 0.5 12 6.4 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF668) DUF3420 PF11900.8 AIF83204.1 - 0.29 11.3 1.7 0.78 9.9 0.4 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3420) 3-dmu-9_3-mt PF06983.13 AIF83205.1 - 1.3e-44 151.4 0.3 1.9e-44 150.9 0.3 1.2 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase AHSA1 PF08327.11 AIF83206.1 - 2.3e-24 86.0 0.7 2.8e-24 85.7 0.7 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 AIF83206.1 - 7.7e-06 26.2 1.3 1.3e-05 25.5 1.3 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport ABM PF03992.16 AIF83208.1 - 0.003 17.6 0.0 0.0056 16.8 0.0 1.4 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase TM_helix PF05552.12 AIF83208.1 - 0.19 11.8 1.4 0.29 11.1 0.4 2.0 1 1 1 2 2 2 0 Conserved TM helix PLDc_2 PF13091.6 AIF83209.1 - 4.8e-11 42.7 1.4 8.5e-11 41.9 1.4 1.3 1 0 0 1 1 1 1 PLD-like domain RE_NgoFVII PF09565.10 AIF83209.1 - 0.0081 15.5 0.4 0.015 14.7 0.4 1.4 1 0 0 1 1 1 1 NgoFVII restriction endonuclease PP_kinase_C PF13090.6 AIF83209.1 - 0.0097 15.4 1.5 0.014 14.9 0.4 1.8 2 0 0 2 2 2 1 Polyphosphate kinase C-terminal domain 2 DDE_Tnp_1 PF01609.21 AIF83212.1 - 2.9e-21 76.1 1.1 1e-20 74.3 1.1 1.8 1 1 0 1 1 1 1 Transposase DDE domain EF_assoc_1 PF08355.12 AIF83213.1 - 0.19 11.3 1.4 2.2 8.0 0.0 2.5 2 1 1 3 3 3 0 EF hand associated ParE-like_toxin PF15781.5 AIF83214.1 - 1.1e-11 44.5 0.8 1.4e-11 44.2 0.3 1.4 2 0 0 2 2 2 1 ParE-like toxin of type II bacterial toxin-antitoxin system ParE_toxin PF05016.15 AIF83214.1 - 1.4e-07 32.0 0.5 2.8e-07 31.1 0.2 1.6 1 1 1 2 2 2 1 ParE toxin of type II toxin-antitoxin system, parDE DUF5358 PF17311.2 AIF83214.1 - 0.0068 16.4 1.1 0.0078 16.2 1.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5358) Gp49 PF05973.14 AIF83214.1 - 0.022 14.9 0.1 0.043 14.0 0.0 1.5 1 1 0 1 1 1 0 Phage derived protein Gp49-like (DUF891) YoeB_toxin PF06769.14 AIF83214.1 - 0.032 14.3 0.0 0.059 13.4 0.0 1.4 1 1 0 1 1 1 0 YoeB-like toxin of bacterial type II toxin-antitoxin system BCL_N PF04714.13 AIF83214.1 - 0.046 13.8 0.5 0.62 10.2 0.0 2.2 2 0 0 2 2 2 0 BCL7, N-terminal conserver region Memo PF01875.17 AIF83214.1 - 0.081 12.1 0.0 0.098 11.8 0.0 1.0 1 0 0 1 1 1 0 Memo-like protein Methylase_S PF01420.19 AIF83215.1 - 2.4e-10 40.9 0.3 0.00012 22.3 0.1 2.3 2 0 0 2 2 2 2 Type I restriction modification DNA specificity domain N6_Mtase PF02384.16 AIF83216.1 - 8.8e-32 110.6 0.0 3e-31 108.9 0.0 1.9 2 0 0 2 2 2 1 N-6 DNA Methylase HSDR_N_2 PF13588.6 AIF83216.1 - 9.8e-27 93.1 0.0 2.6e-26 91.8 0.0 1.7 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) UPF0020 PF01170.18 AIF83216.1 - 2.5e-08 33.9 0.0 6.9e-08 32.4 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.14 AIF83216.1 - 0.00033 20.3 0.0 0.47 10.0 0.0 3.3 3 0 0 3 3 3 1 Methyltransferase small domain Methyltransf_31 PF13847.6 AIF83216.1 - 0.013 15.3 0.0 0.16 11.8 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain HSDR_N PF04313.14 AIF83216.1 - 0.044 13.7 0.0 0.46 10.4 0.0 2.4 1 1 1 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Thioredoxin_4 PF13462.6 AIF83220.1 - 1e-28 100.6 0.0 1.2e-28 100.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 AIF83220.1 - 9.7e-19 67.9 1.0 1.7e-16 60.6 1.0 2.1 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_5 PF13743.6 AIF83220.1 - 0.00044 20.0 0.0 0.0021 17.7 0.0 1.8 1 1 1 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 AIF83220.1 - 0.0005 20.5 0.0 0.0012 19.2 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 AIF83220.1 - 0.094 12.5 0.0 0.27 11.0 0.0 1.8 2 0 0 2 2 2 0 F plasmid transfer operon protein zf-Mss51 PF13824.6 AIF83220.1 - 6.1 7.0 6.1 8.1 6.6 0.1 3.4 4 0 0 4 4 4 0 Zinc-finger of mitochondrial splicing suppressor 51 AhpC-TSA PF00578.21 AIF83221.1 - 2e-34 118.2 0.0 2.4e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIF83221.1 - 5.4e-19 68.4 0.0 6.9e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 Redoxin adh_short_C2 PF13561.6 AIF83222.1 - 5.7e-64 215.9 0.0 6.8e-64 215.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 AIF83222.1 - 5.4e-50 169.6 0.1 6.4e-50 169.3 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AIF83222.1 - 1.2e-11 44.9 0.0 1.7e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 KR domain Adenine_deam_C PF13382.6 AIF83222.1 - 0.023 14.0 0.2 0.069 12.5 0.2 1.7 2 0 0 2 2 2 0 Adenine deaminase C-terminal domain KORA PF16509.5 AIF83222.1 - 0.03 14.6 0.3 8.7 6.7 0.2 2.6 1 1 1 2 2 2 0 TrfB plasmid transcriptional repressor 3HCDH_N PF02737.18 AIF83222.1 - 0.11 12.3 0.2 0.18 11.7 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_hydro_1 PF00232.18 AIF83222.1 - 0.13 10.6 0.1 0.18 10.2 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 ChapFlgA_N PF17656.1 AIF83222.1 - 0.14 12.3 0.2 0.81 9.9 0.1 2.1 2 0 0 2 2 2 0 FlgA N-terminal domain Glyoxalase PF00903.25 AIF83223.1 - 3e-28 98.6 0.1 9.4e-14 51.7 0.1 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DHFR_2 PF06442.11 AIF83223.1 - 0.0029 17.4 0.0 0.71 9.8 0.0 2.4 1 1 1 2 2 2 2 R67 dihydrofolate reductase CppA_N PF14506.6 AIF83223.1 - 0.22 11.6 0.0 5.6 7.0 0.0 2.3 2 0 0 2 2 2 0 CppA N-terminal Abhydrolase_2 PF02230.16 AIF83224.1 - 1.1e-10 41.7 0.0 2e-10 40.9 0.0 1.3 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.18 AIF83224.1 - 6.1e-08 32.5 0.0 9.2e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 AIF83224.1 - 1e-06 28.4 0.1 0.047 13.2 0.0 2.5 2 1 1 3 3 3 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 AIF83224.1 - 1.1e-06 28.1 0.2 0.00099 18.4 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AIF83224.1 - 0.00029 20.6 0.0 0.0066 16.1 0.0 2.4 1 1 1 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.13 AIF83224.1 - 0.0013 18.5 1.0 0.0055 16.4 0.1 2.2 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 AIF83224.1 - 0.0047 16.8 0.1 0.017 15.0 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 AIF83224.1 - 0.19 11.3 0.0 0.28 10.8 0.0 1.3 1 1 0 1 1 1 0 Putative esterase Esterase_phd PF10503.9 AIF83224.1 - 0.26 10.8 0.7 2.1 7.8 0.1 2.4 2 2 1 3 3 3 0 Esterase PHB depolymerase DUF4937 PF16291.5 AIF83225.1 - 0.018 15.3 0.1 0.044 14.0 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4937 ABM PF03992.16 AIF83225.1 - 0.033 14.3 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase TFIIE_alpha PF02002.17 AIF83226.1 - 0.0044 16.9 0.0 0.0053 16.6 0.0 1.1 1 0 0 1 1 1 1 TFIIE alpha subunit Putative_PNPOx PF01243.20 AIF83227.1 - 1.1e-11 44.7 0.0 1.6e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AIF83227.1 - 0.0027 17.7 0.0 0.0033 17.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Ferritin PF00210.24 AIF83229.1 - 9e-26 90.5 0.1 1.1e-25 90.2 0.1 1.1 1 0 0 1 1 1 1 Ferritin-like domain MAAL_C PF07476.11 AIF83229.1 - 0.0014 17.8 0.4 0.071 12.2 0.1 2.1 1 1 1 2 2 2 2 Methylaspartate ammonia-lyase C-terminus Cupin_1 PF00190.22 AIF83230.1 - 3.5e-39 133.8 0.0 5.8e-20 71.4 0.0 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 AIF83230.1 - 1.4e-22 79.1 2.3 5.3e-12 45.3 1.0 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 AIF83230.1 - 0.0012 18.5 0.0 0.36 10.6 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 AIF83230.1 - 0.024 14.6 0.6 0.32 10.9 0.2 2.3 2 0 0 2 2 2 0 AraC-like ligand binding domain NMD3 PF04981.13 AIF83231.1 - 0.0051 16.3 0.3 0.0053 16.3 0.3 1.0 1 0 0 1 1 1 1 NMD3 family zf-Mss51 PF13824.6 AIF83231.1 - 0.026 14.6 0.1 0.038 14.1 0.1 1.3 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 SR1P PF13790.6 AIF83231.1 - 0.054 13.6 0.4 0.091 12.9 0.4 1.3 1 0 0 1 1 1 0 SR1 protein Lar_restr_allev PF14354.6 AIF83231.1 - 0.083 13.3 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 Restriction alleviation protein Lar ADK_lid PF05191.14 AIF83231.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Adenylate kinase, active site lid PhetRS_B1 PF18262.1 AIF83232.1 - 3.6 7.9 6.6 5.1 7.4 6.2 1.6 1 1 1 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain RRN3 PF05327.11 AIF83232.1 - 7.3 5.0 13.7 8.5 4.8 13.7 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PAP_PilO PF06864.12 AIF83233.1 - 0.00075 18.4 0.0 0.00091 18.2 0.0 1.2 1 0 0 1 1 1 1 Pilin accessory protein (PilO) DUF1043 PF06295.12 AIF83233.1 - 0.00099 19.1 0.1 0.0025 17.8 0.0 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1043) Gly-zipper_Omp PF13488.6 AIF83233.1 - 0.0013 18.7 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 Glycine zipper Vpu PF00558.19 AIF83233.1 - 0.0041 16.9 4.7 0.0071 16.1 2.9 2.0 1 1 1 2 2 2 1 Vpu protein Halogen_Hydrol PF10112.9 AIF83233.1 - 0.0068 16.4 0.3 0.0085 16.1 0.3 1.1 1 0 0 1 1 1 1 5-bromo-4-chloroindolyl phosphate hydrolysis protein XhlA PF10779.9 AIF83233.1 - 0.01 16.0 14.9 0.082 13.1 9.2 2.6 2 1 0 2 2 2 0 Haemolysin XhlA LapA_dom PF06305.11 AIF83233.1 - 0.012 15.4 0.2 0.012 15.4 0.2 2.1 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Glt_symporter PF03616.14 AIF83233.1 - 0.021 13.5 0.0 0.022 13.5 0.0 1.1 1 0 0 1 1 1 0 Sodium/glutamate symporter Matrilin_ccoil PF10393.9 AIF83233.1 - 0.023 14.6 2.9 0.039 13.8 0.2 2.5 1 1 1 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin YebO PF13974.6 AIF83233.1 - 0.026 14.6 0.3 0.086 12.9 0.3 1.8 1 1 0 1 1 1 0 YebO-like protein Chordopox_A13L PF05961.11 AIF83233.1 - 0.026 14.8 0.0 0.05 13.8 0.0 1.6 1 0 0 1 1 1 0 Chordopoxvirus A13L protein FTR1 PF03239.14 AIF83233.1 - 0.058 12.6 0.0 0.095 11.9 0.0 1.3 1 0 0 1 1 1 0 Iron permease FTR1 family Tho2 PF11262.8 AIF83233.1 - 0.062 12.5 1.5 0.068 12.4 1.5 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 FeoB_associated PF12669.7 AIF83233.1 - 0.073 13.5 0.1 0.12 12.8 0.1 1.3 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein PTS_EIIC PF02378.18 AIF83233.1 - 0.082 11.9 0.0 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase system, EIIC DUF1296 PF06972.11 AIF83233.1 - 0.083 13.0 3.9 0.15 12.2 3.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1296) LOH1CR12 PF10158.9 AIF83233.1 - 0.093 12.8 2.0 0.13 12.3 2.0 1.2 1 0 0 1 1 1 0 Tumour suppressor protein Suppressor_APC PF11414.8 AIF83233.1 - 0.16 12.0 4.1 0.24 11.5 4.1 1.3 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein Vac_Fusion PF02346.16 AIF83233.1 - 0.42 10.3 8.6 4.3 7.1 5.9 2.9 1 1 1 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 LMBR1 PF04791.16 AIF83233.1 - 0.5 9.2 0.9 0.49 9.2 0.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3450 PF11932.8 AIF83233.1 - 2.5 7.3 8.3 3.4 6.9 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) P-II PF00543.22 AIF83234.1 - 1.7e-10 41.4 0.2 2e-10 41.2 0.2 1.1 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II ADH_N PF08240.12 AIF83235.1 - 4.8e-31 106.9 1.5 8e-31 106.2 1.5 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIF83235.1 - 2.2e-18 66.5 0.2 4.1e-18 65.6 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AIF83235.1 - 7.2e-05 23.8 0.0 0.00021 22.3 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 AIF83235.1 - 0.02 14.2 0.1 0.045 13.0 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 AIF83235.1 - 0.069 12.5 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_N PF08240.12 AIF83236.1 - 4.4e-33 113.4 0.1 7e-33 112.8 0.1 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIF83236.1 - 1.3e-27 96.4 0.5 2e-27 95.7 0.1 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AIF83236.1 - 1.6e-13 51.9 0.1 2.8e-13 51.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 AIF83236.1 - 4.6e-05 22.8 0.7 7.2e-05 22.2 0.7 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Glu_dehyd_C PF16912.5 AIF83236.1 - 0.00086 18.9 0.3 0.0014 18.1 0.3 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus PglD_N PF17836.1 AIF83236.1 - 0.007 17.0 0.4 0.016 15.8 0.4 1.7 1 0 0 1 1 1 1 PglD N-terminal domain Methyltransf_25 PF13649.6 AIF83236.1 - 0.02 15.6 0.1 0.033 14.9 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain TrkA_N PF02254.18 AIF83236.1 - 0.025 14.9 0.1 0.056 13.7 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Methyltransf_11 PF08241.12 AIF83236.1 - 0.095 13.4 0.0 0.19 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 AIF83236.1 - 0.097 12.0 1.1 0.14 11.5 1.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DapB_N PF01113.20 AIF83236.1 - 0.11 12.7 0.8 0.2 11.8 0.8 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus CoA_binding PF02629.19 AIF83236.1 - 0.11 13.1 0.3 0.23 12.1 0.3 1.5 1 0 0 1 1 1 0 CoA binding domain ThiF PF00899.21 AIF83236.1 - 0.13 11.6 0.1 0.32 10.3 0.1 1.6 1 0 0 1 1 1 0 ThiF family MTS PF05175.14 AIF83236.1 - 0.16 11.5 0.2 0.24 10.9 0.2 1.3 1 0 0 1 1 1 0 Methyltransferase small domain MFS_1 PF07690.16 AIF83237.1 - 2.7e-44 151.6 49.4 1.4e-32 113.0 26.9 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5519 PF17648.1 AIF83237.1 - 4.2e-18 65.3 0.0 1.9e-10 40.6 0.0 2.4 2 0 0 2 2 2 2 Family of unknown function (DUF5519) NPCC PF08058.11 AIF83237.1 - 0.041 13.9 0.3 0.15 12.1 0.0 2.2 2 0 0 2 2 2 0 Nuclear pore complex component OATP PF03137.20 AIF83237.1 - 0.48 8.7 20.8 0.091 11.0 0.5 3.8 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Spt20 PF12090.8 AIF83237.1 - 1.3 8.6 3.6 0.26 10.9 0.1 1.5 2 0 0 2 2 2 0 Spt20 family Neur_chan_memb PF02932.16 AIF83237.1 - 1.5 8.8 4.7 5 7.1 4.7 1.9 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MFS_2 PF13347.6 AIF83237.1 - 5.5 5.4 39.7 0.22 10.1 8.1 3.4 3 1 0 3 3 3 0 MFS/sugar transport protein MRJP PF03022.16 AIF83238.1 - 1e-35 123.5 0.0 1.5e-35 123.0 0.0 1.2 1 0 0 1 1 1 1 Major royal jelly protein SGL PF08450.12 AIF83238.1 - 0.00057 19.5 0.0 0.0064 16.1 0.1 2.5 2 2 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 AIF83238.1 - 0.0039 17.2 0.8 2.3 8.4 0.0 3.8 5 0 0 5 5 5 2 NHL repeat Aldedh PF00171.22 AIF83239.1 - 1.2e-145 485.6 0.6 1.4e-145 485.4 0.6 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family S4 PF01479.25 AIF83239.1 - 0.16 11.7 0.0 0.86 9.4 0.0 2.3 2 0 0 2 2 2 0 S4 domain DUF3793 PF12672.7 AIF83241.1 - 0.051 13.6 0.0 0.075 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) YebO PF13974.6 AIF83242.1 - 0.12 12.5 0.3 0.2 11.8 0.3 1.4 1 1 0 1 1 1 0 YebO-like protein zf_C2H2_ZHX PF18387.1 AIF83243.1 - 5.7e-05 22.7 0.1 0.00011 21.7 0.1 1.5 1 0 0 1 1 1 1 Zinc-fingers and homeoboxes C2H2 finger domain HTH_IclR PF09339.10 AIF83243.1 - 0.00037 20.2 0.9 0.0035 17.1 0.3 2.4 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_DeoR PF08220.12 AIF83243.1 - 0.0013 18.5 0.8 0.0029 17.3 0.1 1.9 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_20 PF12840.7 AIF83243.1 - 0.0039 17.2 0.1 0.0083 16.2 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain Fe_dep_repress PF01325.19 AIF83243.1 - 0.0043 17.2 0.0 0.042 14.1 0.0 2.5 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain MarR_2 PF12802.7 AIF83243.1 - 0.0064 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIF83243.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB zf-C2H2_4 PF13894.6 AIF83243.1 - 0.051 14.4 0.9 0.15 13.0 0.9 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger HTH_Crp_2 PF13545.6 AIF83243.1 - 0.053 13.5 0.3 0.28 11.2 0.0 2.3 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_11 PF08279.12 AIF83243.1 - 0.053 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 HTH domain Replic_Relax PF13814.6 AIF83243.1 - 0.058 13.4 0.1 0.19 11.8 0.1 1.9 1 1 1 2 2 2 0 Replication-relaxation Dimerisation2 PF16864.5 AIF83243.1 - 0.073 13.1 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Dimerisation domain zf-C2H2 PF00096.26 AIF83243.1 - 0.077 13.5 1.1 0.23 12.0 1.1 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type Rrf2 PF02082.20 AIF83243.1 - 0.091 13.1 0.0 0.31 11.4 0.0 1.8 2 0 0 2 2 2 0 Transcriptional regulator Dimerisation PF08100.11 AIF83243.1 - 0.092 12.8 0.0 0.81 9.8 0.0 2.4 2 0 0 2 2 2 0 Dimerisation domain CR6_interact PF10147.9 AIF83243.1 - 0.1 12.3 3.0 0.16 11.6 3.0 1.2 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 HrcA_DNA-bdg PF03444.15 AIF83243.1 - 0.11 12.2 0.0 0.28 10.8 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding AAA_lid_2 PF17863.1 AIF83243.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA lid domain ADH_N PF08240.12 AIF83244.1 - 0.055 13.3 0.2 4.6 7.2 0.1 2.1 1 1 1 2 2 2 0 Alcohol dehydrogenase GroES-like domain HTH_37 PF13744.6 AIF83248.1 - 0.077 13.0 0.1 0.21 11.6 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4367 PF14285.6 AIF83249.1 - 2.1e-05 24.9 0.0 0.0036 17.7 0.1 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4367) zf-ribbon_3 PF13248.6 AIF83251.1 - 0.045 13.2 0.2 0.06 12.8 0.2 1.2 1 0 0 1 1 1 0 zinc-ribbon domain Phage_integrase PF00589.22 AIF83252.1 - 3.5e-12 46.4 0.1 5.2e-12 45.9 0.1 1.2 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_4 PF13495.6 AIF83252.1 - 0.021 15.3 0.0 0.06 13.8 0.0 1.8 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Peptidase_U4 PF03419.13 AIF83253.1 - 0.13 11.5 9.3 0.16 11.2 9.3 1.0 1 0 0 1 1 1 0 Sporulation factor SpoIIGA CPP1-like PF11833.8 AIF83253.1 - 0.76 9.4 3.9 1.6 8.3 1.8 1.9 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF2207 PF09972.9 AIF83254.1 - 0.28 9.9 1.1 0.3 9.8 1.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3671 PF12420.8 AIF83254.1 - 0.69 10.0 3.3 0.86 9.7 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function ParBc PF02195.18 AIF83255.1 - 2.8e-18 66.0 0.1 1e-17 64.2 0.0 1.9 2 0 0 2 2 2 1 ParB-like nuclease domain DZR PF12773.7 AIF83256.1 - 0.0024 17.9 0.5 0.0052 16.8 0.5 1.5 1 0 0 1 1 1 1 Double zinc ribbon DUF2387 PF09526.10 AIF83256.1 - 0.057 13.6 5.3 0.3 11.3 5.3 2.1 1 1 0 1 1 1 0 Probable metal-binding protein (DUF2387) Phage_int_SAM_4 PF13495.6 AIF83256.1 - 0.071 13.6 2.9 0.3 11.6 2.9 2.2 1 1 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain zinc_ribbon_2 PF13240.6 AIF83256.1 - 0.091 12.5 1.2 0.19 11.5 1.2 1.6 1 0 0 1 1 1 0 zinc-ribbon domain UPF0547 PF10571.9 AIF83256.1 - 0.11 12.6 2.6 0.22 11.7 2.6 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-ACC PF17848.1 AIF83256.1 - 0.51 10.5 5.2 0.71 10.0 0.1 2.7 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain Radical_SAM PF04055.21 AIF83257.1 - 1.3e-10 41.9 0.3 6e-10 39.7 0.3 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 AIF83257.1 - 3.5e-08 33.8 0.1 6.6e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 AIF83257.1 - 9.7e-06 25.7 0.4 3.3e-05 24.0 0.2 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain EndIII_4Fe-2S PF10576.9 AIF83257.1 - 0.044 14.1 0.2 0.12 12.7 0.2 1.8 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Cyclase PF04199.13 AIF83258.1 - 7.2e-32 110.5 0.1 8.9e-32 110.2 0.1 1.1 1 0 0 1 1 1 1 Putative cyclase AsnC_trans_reg PF01037.21 AIF83259.1 - 3.4e-12 46.2 0.1 3.7e-12 46.0 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIF83259.1 - 0.076 13.1 0.1 0.1 12.7 0.1 1.2 1 0 0 1 1 1 0 NapD protein Aminotran_5 PF00266.19 AIF83260.1 - 4.6e-66 223.3 0.0 5.4e-66 223.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Rad51 PF08423.11 AIF83261.1 - 0.051 12.8 0.1 0.1 11.9 0.1 1.8 1 1 0 1 1 1 0 Rad51 AAA_24 PF13479.6 AIF83261.1 - 0.07 12.8 0.0 0.079 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain TMEM125 PF15109.6 AIF83262.1 - 0.1 13.0 1.1 0.13 12.6 0.7 1.4 1 1 0 1 1 1 0 TMEM125 protein family OST3_OST6 PF04756.13 AIF83262.1 - 0.23 10.8 1.0 0.28 10.5 1.0 1.3 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family DUF3995 PF13160.6 AIF83262.1 - 0.48 10.8 9.0 0.2 12.0 6.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3995) zf-HYPF PF07503.12 AIF83263.1 - 0.079 12.8 1.3 0.12 12.2 1.3 1.3 1 0 0 1 1 1 0 HypF finger Cpn60_TCP1 PF00118.24 AIF83264.1 - 1.3e-183 611.1 21.8 1.5e-183 610.9 21.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Rhomboid PF01694.22 AIF83265.1 - 7.8e-37 126.6 18.6 1.4e-36 125.7 18.6 1.3 1 0 0 1 1 1 1 Rhomboid family DUF1751 PF08551.10 AIF83265.1 - 0.078 13.6 0.3 0.078 13.6 0.3 2.5 2 1 1 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) zf-C2H2_4 PF13894.6 AIF83266.1 - 1.8e-05 25.2 1.8 2.3e-05 24.8 1.8 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF83266.1 - 2e-05 24.8 2.8 2.5e-05 24.5 2.8 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 AIF83266.1 - 3.1e-05 23.6 4.4 4.2e-05 23.2 4.4 1.2 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 AIF83266.1 - 0.00067 20.0 0.3 0.00072 19.8 0.3 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Actin_micro PF17003.5 AIF83266.1 - 0.00071 18.9 0.2 0.00073 18.8 0.2 1.0 1 0 0 1 1 1 1 Putative actin-like family zf-BED PF02892.15 AIF83266.1 - 0.0014 18.6 0.3 0.0018 18.2 0.3 1.2 1 0 0 1 1 1 1 BED zinc finger PyrI_C PF02748.15 AIF83266.1 - 0.0035 17.2 0.1 0.0047 16.8 0.1 1.3 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 AIF83266.1 - 0.0045 17.2 2.9 0.0062 16.8 2.9 1.2 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 AIF83266.1 - 0.0074 16.7 2.0 1.1 9.8 0.3 2.2 2 0 0 2 2 2 2 Zinc-finger double domain zf-Di19 PF05605.12 AIF83266.1 - 0.02 15.2 0.1 0.025 14.9 0.1 1.1 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding HNH PF01844.23 AIF83266.1 - 0.021 15.0 0.3 0.026 14.7 0.3 1.1 1 0 0 1 1 1 0 HNH endonuclease DUF629 PF04780.12 AIF83266.1 - 0.033 12.7 0.1 0.035 12.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) PHD_Oberon PF07227.11 AIF83266.1 - 0.039 13.8 0.0 0.039 13.8 0.0 1.0 1 0 0 1 1 1 0 PHD - plant homeodomain finger protein zf-C2H2_3rep PF18868.1 AIF83266.1 - 0.06 14.0 0.4 0.069 13.8 0.4 1.1 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats DUF4187 PF13821.6 AIF83266.1 - 0.069 12.9 0.7 0.098 12.4 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) AsnC_trans_reg PF01037.21 AIF83267.1 - 1.4e-12 47.4 0.2 1.4e-12 47.3 0.2 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain MatB PF16449.5 AIF83267.1 - 0.031 14.1 0.0 0.036 13.9 0.0 1.1 1 0 0 1 1 1 0 Fimbrillin MatB GYD PF08734.11 AIF83267.1 - 0.048 13.6 0.1 0.048 13.6 0.1 1.2 1 0 0 1 1 1 0 GYD domain NapD PF03927.13 AIF83267.1 - 0.051 13.6 0.3 0.068 13.2 0.3 1.2 1 0 0 1 1 1 0 NapD protein RecO_N_2 PF13114.6 AIF83267.1 - 0.083 12.6 0.1 0.11 12.2 0.1 1.3 1 1 0 1 1 1 0 RecO N terminal HTH_20 PF12840.7 AIF83268.1 - 0.00012 22.1 0.2 0.0002 21.3 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 AIF83268.1 - 0.036 14.0 0.1 0.88 9.5 0.1 2.2 2 0 0 2 2 2 0 MarR family DUF1724 PF08350.10 AIF83268.1 - 0.1 12.8 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1724) HTH_45 PF14947.6 AIF83268.1 - 0.15 12.0 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix Ribosomal_L11_N PF03946.14 AIF83269.1 - 5.3e-21 74.2 0.7 1.2e-20 73.1 0.7 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 AIF83269.1 - 6.4e-18 65.0 1.6 1.1e-17 64.3 1.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Qn_am_d_aIII PF09099.10 AIF83269.1 - 0.052 13.9 0.4 0.14 12.6 0.2 1.8 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III Peptidase_S8 PF00082.22 AIF83270.1 - 8.3e-33 113.9 1.6 1.8e-32 112.8 1.6 1.6 1 0 0 1 1 1 1 Subtilase family Big_3_3 PF13750.6 AIF83270.1 - 7.3e-10 38.7 0.4 0.0082 15.8 0.0 3.9 4 0 0 4 4 4 3 Bacterial Ig-like domain (group 3) Y_Y_Y PF07495.13 AIF83270.1 - 0.0025 17.7 0.5 0.49 10.4 0.0 3.1 3 0 0 3 3 3 1 Y_Y_Y domain TcfC PF16967.5 AIF83270.1 - 0.036 13.5 0.0 1.3 8.6 0.0 2.7 2 0 0 2 2 2 0 E-set like domain EF-hand_5 PF13202.6 AIF83270.1 - 0.054 13.0 0.1 0.42 10.2 0.0 2.3 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 AIF83270.1 - 0.087 12.8 0.1 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain DUF916 PF06030.12 AIF83270.1 - 0.13 12.4 0.0 33 4.6 0.0 2.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF916) fn3_5 PF06280.12 AIF83270.1 - 0.13 12.9 3.2 0.21 12.3 0.0 2.8 3 1 1 4 4 4 0 Fn3-like domain EF-hand_1 PF00036.32 AIF83270.1 - 0.18 11.4 0.1 1.5 8.6 0.0 2.5 2 0 0 2 2 2 0 EF hand DUF4625 PF15418.6 AIF83270.1 - 0.2 11.9 0.0 15 5.8 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) Thioredoxin PF00085.20 AIF83271.1 - 5.2e-29 100.3 0.0 5.9e-29 100.1 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AIF83271.1 - 5.8e-08 33.2 0.2 1.3e-06 28.8 0.2 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 AIF83271.1 - 1.6e-06 28.4 0.1 0.00017 21.8 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like Redoxin PF08534.10 AIF83271.1 - 2.9e-06 27.1 0.1 5e-06 26.3 0.1 1.5 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 AIF83271.1 - 2e-05 24.5 0.2 7.9e-05 22.6 0.2 1.8 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 AIF83271.1 - 3.8e-05 23.8 0.1 6.2e-05 23.1 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 AIF83271.1 - 0.00022 21.0 0.0 0.00025 20.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 AIF83271.1 - 0.00028 20.3 0.0 0.00033 20.1 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family T4_deiodinase PF00837.17 AIF83271.1 - 0.008 15.5 0.0 0.0087 15.4 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase Thioredoxin_3 PF13192.6 AIF83271.1 - 0.0091 16.0 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain TraF PF13728.6 AIF83271.1 - 0.22 11.3 0.0 0.3 10.9 0.0 1.3 1 1 0 1 1 1 0 F plasmid transfer operon protein GTP_EFTU PF00009.27 AIF83272.1 - 1.7e-30 106.0 0.0 6e-30 104.2 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D4 PF14578.6 AIF83272.1 - 9.4e-25 86.3 2.5 1.1e-24 86.1 0.7 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 4 IF-2 PF11987.8 AIF83272.1 - 3e-20 72.3 2.9 3e-20 72.3 0.8 2.0 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 AIF83272.1 - 6.2e-08 32.7 0.0 2.3e-07 30.9 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 AIF83272.1 - 1.2e-07 32.0 2.1 3.1e-06 27.5 0.0 3.3 3 0 0 3 3 3 1 Elongation factor Tu domain 2 Roc PF08477.13 AIF83272.1 - 6.5e-05 23.1 0.0 0.00017 21.8 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AIF83272.1 - 0.001 18.7 0.0 0.01 15.5 0.0 2.4 1 1 0 1 1 1 1 Ras family ATP_bind_1 PF03029.17 AIF83272.1 - 0.0015 18.4 0.0 0.0079 16.0 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 AIF83272.1 - 0.0016 18.4 2.5 1.8 8.4 0.2 3.2 1 1 1 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 AIF83272.1 - 0.0024 17.9 0.1 0.025 14.7 0.1 2.4 2 0 0 2 2 2 1 Dynamin family SRPRB PF09439.10 AIF83272.1 - 0.0032 16.9 0.2 0.41 10.1 0.0 3.3 3 1 0 3 3 3 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 AIF83272.1 - 0.12 12.2 0.1 1.1 9.0 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 AIF83272.1 - 0.23 11.0 1.1 4.2 6.9 0.1 3.3 3 1 0 3 3 3 0 Ferrous iron transport protein B NDK PF00334.19 AIF83273.1 - 1.1e-46 158.2 0.0 1.2e-46 158.0 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Ribosomal_L24e PF01246.20 AIF83274.1 - 4.7e-19 68.4 0.9 5.4e-19 68.2 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L24e zf-FLZ PF04570.14 AIF83274.1 - 0.0013 18.2 1.0 0.0026 17.2 1.0 1.5 1 1 0 1 1 1 1 zinc-finger of the FCS-type, C2-C2 DUF2175 PF09943.9 AIF83274.1 - 0.026 14.8 0.1 0.027 14.8 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Cas_CXXC_CXXC PF09706.10 AIF83274.1 - 0.046 14.0 0.3 0.058 13.6 0.3 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_CXXC_CXXC) DUF2116 PF09889.9 AIF83274.1 - 0.9 9.6 3.9 8.3 6.5 3.9 2.0 1 1 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Ribosomal_S28e PF01200.18 AIF83275.1 - 2.5e-29 101.1 6.4 2.8e-29 100.9 6.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Ribosomal_L7Ae PF01248.26 AIF83276.1 - 7.8e-27 92.8 0.2 9.8e-27 92.5 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 AIF83276.1 - 0.0069 16.2 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 AIF83276.1 - 0.15 12.1 0.0 0.17 11.9 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit Pop3 Phage_holin_3_6 PF07332.11 AIF83278.1 - 0.00031 20.8 0.0 0.00039 20.4 0.0 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III DUF1643 PF07799.12 AIF83278.1 - 0.041 14.0 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) PgaD PF13994.6 AIF83278.1 - 0.063 13.3 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 PgaD-like protein DUF202 PF02656.15 AIF83278.1 - 8.6 6.9 6.5 33 5.0 6.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Ribonuc_2-5A PF06479.12 AIF83279.1 - 0.23 11.7 3.1 1.7 8.8 0.5 2.2 2 0 0 2 2 2 0 Ribonuclease 2-5A FACT-Spt16_Nlob PF14826.6 AIF83280.1 - 0.047 13.5 0.1 0.062 13.1 0.1 1.1 1 0 0 1 1 1 0 FACT complex subunit SPT16 N-terminal lobe domain MFS18 PF17352.2 AIF83283.1 - 0.077 13.4 0.5 0.12 12.8 0.5 1.4 1 0 0 1 1 1 0 Male Flower Specific protein 18 Gram_pos_anchor PF00746.21 AIF83283.1 - 0.59 10.1 6.0 0.49 10.4 0.4 2.6 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF2207 PF09972.9 AIF83284.1 - 0.05 12.4 4.0 0.026 13.3 1.7 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) ETRAMP PF09716.10 AIF83284.1 - 0.097 12.7 0.5 1.5 8.9 0.2 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) FKS1_dom1 PF14288.6 AIF83285.1 - 0.026 14.9 2.3 1.7 9.0 0.0 3.2 3 0 0 3 3 3 0 1,3-beta-glucan synthase subunit FKS1, domain-1 FANCI_S3 PF14677.6 AIF83285.1 - 0.027 14.2 0.4 0.062 13.0 0.0 1.8 2 0 0 2 2 2 0 FANCI solenoid 3 Phage_HK97_TLTM PF06120.11 AIF83285.1 - 0.1 11.7 1.8 0.15 11.3 0.6 1.8 2 0 0 2 2 2 0 Tail length tape measure protein Prim-Pol PF09250.11 AIF83286.1 - 1.5e-10 41.6 0.1 2.6e-10 40.9 0.1 1.3 1 0 0 1 1 1 1 Bifunctional DNA primase/polymerase, N-terminal TMF_TATA_bd PF12325.8 AIF83287.1 - 0.031 14.5 1.4 0.048 13.9 0.9 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF3781 PF12636.7 AIF83287.1 - 0.041 13.7 0.4 0.041 13.7 0.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3781) Myb_DNA-bind_7 PF15963.5 AIF83287.1 - 0.094 12.6 1.1 0.16 11.9 1.1 1.3 1 0 0 1 1 1 0 Myb DNA-binding like DUF3105 PF11303.8 AIF83292.1 - 0.11 12.6 0.0 0.11 12.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3105) Seryl_tRNA_N PF02403.22 AIF83294.1 - 0.035 14.4 11.2 0.87 9.8 6.3 3.4 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Bap31_Bap29_C PF18035.1 AIF83294.1 - 0.054 13.5 3.4 0.26 11.3 3.4 2.3 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain HTH_38 PF13936.6 AIF83294.1 - 0.1 12.4 0.2 0.31 10.8 0.2 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain Phage_integrase PF00589.22 AIF83294.1 - 0.55 10.0 4.5 0.59 9.9 0.5 3.0 2 1 0 2 2 2 0 Phage integrase family PGM_PMM_I PF02878.16 AIF83295.1 - 3.5e-39 133.7 0.0 9.7e-39 132.2 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 AIF83295.1 - 2.2e-26 92.5 0.3 4.7e-26 91.4 0.1 1.7 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 AIF83295.1 - 2.4e-22 79.3 0.0 4.5e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 AIF83295.1 - 1.9e-10 40.7 0.0 4.8e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain AhpC-TSA PF00578.21 AIF83296.1 - 8.9e-08 32.1 0.0 1e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family DUF4277 PF14104.6 AIF83296.1 - 0.082 13.3 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4277) Peptidase_M32 PF02074.15 AIF83297.1 - 5.4e-160 533.4 0.2 6.1e-160 533.2 0.2 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase TrmB PF01978.19 AIF83297.1 - 0.01 15.7 0.0 0.036 13.9 0.0 1.9 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB ThylakoidFormat PF11264.8 AIF83297.1 - 0.042 13.6 0.5 0.1 12.3 0.3 1.7 2 0 0 2 2 2 0 Thylakoid formation protein PAS_8 PF13188.7 AIF83297.1 - 0.047 13.7 0.0 0.21 11.7 0.0 2.1 2 0 0 2 2 2 0 PAS domain SNO PF01174.19 AIF83299.1 - 9.4e-51 172.3 0.2 1.1e-50 172.2 0.2 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 AIF83299.1 - 4.8e-13 49.1 0.1 1.3e-12 47.7 0.1 1.6 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 AIF83299.1 - 2.6e-08 33.9 0.1 8.3e-08 32.2 0.1 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIF83299.1 - 2.9e-05 24.0 0.1 0.0013 18.5 0.1 2.4 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 AIF83299.1 - 0.0065 16.3 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Peptidase_S51 PF03575.17 AIF83299.1 - 0.022 14.4 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S51 SOR_SNZ PF01680.17 AIF83300.1 - 7.3e-98 326.4 5.8 1.1e-97 325.8 5.8 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 AIF83300.1 - 6.6e-08 32.2 6.8 8e-07 28.6 0.2 3.0 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 AIF83300.1 - 2.5e-06 27.1 1.6 0.011 15.2 0.1 3.2 2 1 0 2 2 2 2 Histidine biosynthesis protein Dus PF01207.17 AIF83300.1 - 8.8e-06 25.0 0.6 0.083 12.0 0.2 2.3 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.15 AIF83300.1 - 0.00028 20.4 7.9 0.16 11.4 1.6 2.9 2 1 1 3 3 3 2 Nitronate monooxygenase IGPS PF00218.21 AIF83300.1 - 0.00075 18.7 0.0 0.066 12.4 0.0 2.4 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase NanE PF04131.14 AIF83300.1 - 0.01 15.0 3.7 0.23 10.6 0.0 2.9 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase Peptidase_S66C PF17676.1 AIF83300.1 - 0.031 14.8 0.0 0.068 13.7 0.0 1.6 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain TetR_C_27 PF17935.1 AIF83300.1 - 0.055 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain PA PF02225.22 AIF83300.1 - 0.078 13.0 1.7 0.1 12.7 0.4 1.9 2 0 0 2 2 2 0 PA domain Aconitase PF00330.20 AIF83302.1 - 1e-145 486.3 0.0 1.5e-145 485.7 0.0 1.3 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AIF83302.1 - 6.5e-37 126.8 0.0 1.2e-36 126.0 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain POR_N PF01855.19 AIF83304.1 - 7.9e-65 218.8 0.1 1.1e-64 218.3 0.1 1.2 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.18 AIF83304.1 - 1.4e-36 126.2 0.3 3.2e-36 125.0 0.1 1.7 2 0 0 2 2 2 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PFOR_II PF17147.4 AIF83304.1 - 5.5e-10 39.5 0.0 1.5e-09 38.0 0.0 1.8 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Transketolase_C PF02780.20 AIF83304.1 - 9.5e-09 35.2 0.0 2.3e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_N PF02776.18 AIF83304.1 - 0.0044 16.6 0.1 0.0099 15.5 0.1 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 AIF83305.1 - 9e-31 106.7 0.1 1.5e-30 106.0 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PFO_beta_C PF12367.8 AIF83305.1 - 6.3e-18 64.7 1.2 6.1e-16 58.3 0.9 2.9 2 1 0 2 2 2 1 Pyruvate ferredoxin oxidoreductase beta subunit C terminal ChaB PF06150.12 AIF83306.1 - 2.6e-17 63.1 2.7 3.6e-17 62.7 2.7 1.2 1 0 0 1 1 1 1 ChaB DUF3619 PF12279.8 AIF83306.1 - 0.2 12.0 1.5 0.24 11.7 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) DUF2207 PF09972.9 AIF83307.1 - 0.0067 15.2 0.9 0.0069 15.2 0.9 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) MscS_TM PF12794.7 AIF83307.1 - 0.023 13.6 0.1 0.023 13.6 0.1 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 2TM PF13239.6 AIF83307.1 - 0.051 13.9 1.2 0.07 13.4 1.2 1.2 1 0 0 1 1 1 0 2TM domain TRAP-gamma PF07074.12 AIF83307.1 - 0.088 12.4 0.3 0.098 12.2 0.3 1.1 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) QCR10 PF09796.9 AIF83307.1 - 0.17 12.0 2.2 11 6.2 0.6 2.2 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) AsnC_trans_reg PF01037.21 AIF83308.1 - 1.2e-13 50.8 0.3 1.3e-13 50.6 0.3 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain ACT_5 PF13710.6 AIF83308.1 - 0.017 14.9 0.1 5.4 6.9 0.0 2.2 2 0 0 2 2 2 0 ACT domain Spore_YhcN_YlaJ PF09580.10 AIF83308.1 - 0.043 13.9 0.8 0.054 13.6 0.8 1.1 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) ADK_lid PF05191.14 AIF83310.1 - 0.13 12.3 0.1 0.67 10.0 0.0 2.0 2 0 0 2 2 2 0 Adenylate kinase, active site lid Copper-bind PF00127.20 AIF83311.1 - 6.3e-05 23.4 0.0 0.0001 22.7 0.0 1.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF83311.1 - 0.00059 19.9 0.0 0.00077 19.5 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain DBD_Tnp_Hermes PF10683.9 AIF83311.1 - 0.078 12.7 0.0 0.33 10.7 0.0 2.0 2 0 0 2 2 2 0 Hermes transposase DNA-binding domain AsnC_trans_reg PF01037.21 AIF83312.1 - 2.4e-11 43.5 0.0 2.4e-11 43.4 0.0 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIF83312.1 - 0.002 18.1 0.2 0.0024 17.9 0.2 1.1 1 0 0 1 1 1 1 NapD protein ACT_4 PF13291.6 AIF83312.1 - 0.021 15.4 0.3 0.028 15.0 0.3 1.2 1 0 0 1 1 1 0 ACT domain ABC_tran PF00005.27 AIF83314.1 - 8.5e-22 78.1 0.0 1.6e-21 77.2 0.0 1.5 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 AIF83314.1 - 6.5e-11 42.1 0.7 1.1e-09 38.1 0.7 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 AIF83314.1 - 4e-10 40.0 0.1 0.00069 19.5 0.2 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AIF83314.1 - 2.7e-05 23.8 0.1 6.3e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AIF83314.1 - 0.00018 21.5 0.2 0.00043 20.2 0.2 1.8 1 1 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 AIF83314.1 - 0.00018 22.1 0.1 0.00037 21.1 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_13 PF13166.6 AIF83314.1 - 0.00062 18.6 0.1 0.19 10.3 0.0 2.1 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 AIF83314.1 - 0.00095 19.0 0.0 0.018 14.8 0.1 2.2 1 1 0 2 2 2 1 AAA ATPase domain AAA_27 PF13514.6 AIF83314.1 - 0.002 17.7 0.1 0.0048 16.5 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 AIF83314.1 - 0.0028 17.3 0.0 0.064 12.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 AIF83314.1 - 0.0067 16.6 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIF83314.1 - 0.011 16.2 0.0 0.031 14.7 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 AIF83314.1 - 0.02 15.2 0.1 0.16 12.2 0.1 2.4 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 AIF83314.1 - 0.02 15.3 0.1 0.1 13.0 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 AIF83314.1 - 0.024 15.2 0.3 0.23 12.0 0.1 2.4 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 AIF83314.1 - 0.026 14.6 0.0 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Dynamin family AAA_28 PF13521.6 AIF83314.1 - 0.029 14.6 0.0 0.13 12.5 0.0 2.0 1 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 AIF83314.1 - 0.031 14.4 0.4 0.079 13.0 0.1 1.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase MutS_V PF00488.21 AIF83314.1 - 0.046 13.7 0.4 1.5 8.9 0.0 2.1 2 0 0 2 2 2 0 MutS domain V IstB_IS21 PF01695.17 AIF83314.1 - 0.064 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 AIF83314.1 - 0.067 13.6 0.0 0.49 10.8 0.0 2.1 2 0 0 2 2 2 0 RNA helicase ABC_ATPase PF09818.9 AIF83314.1 - 0.073 11.9 0.1 0.12 11.1 0.1 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class T2SSE PF00437.20 AIF83314.1 - 0.077 12.0 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 AIF83314.1 - 0.1 12.5 0.0 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 AIF83314.1 - 0.11 12.4 0.1 0.27 11.1 0.1 1.7 2 1 0 2 2 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 AIF83314.1 - 0.12 11.6 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AIG1 PF04548.16 AIF83314.1 - 0.13 11.5 0.3 0.77 9.0 0.0 2.0 2 0 0 2 2 2 0 AIG1 family ATP_bind_1 PF03029.17 AIF83314.1 - 0.14 12.0 0.2 0.72 9.6 0.0 2.3 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 AIF83314.1 - 0.17 11.6 0.2 0.44 10.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain Chlor_dismutase PF06778.12 AIF83315.1 - 1.5e-60 204.1 0.9 1.8e-60 203.8 0.9 1.1 1 0 0 1 1 1 1 Chlorite dismutase DUF1802 PF08819.11 AIF83316.1 - 7.6e-57 191.9 0.1 8.5e-57 191.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1802) Aldo_ket_red PF00248.21 AIF83317.1 - 9.3e-56 189.2 0.2 1.1e-55 188.9 0.2 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family AsnC_trans_reg2 PF17805.1 AIF83318.1 - 1.7e-55 185.1 0.1 6.7e-29 99.9 0.0 2.9 3 0 0 3 3 3 2 AsnC-like ligand binding domain HTH_AsnC-type PF13404.6 AIF83318.1 - 1.2e-07 31.4 0.0 0.00058 19.6 0.0 2.6 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 AIF83318.1 - 7.8e-06 25.8 0.0 0.031 14.3 0.0 2.9 2 1 0 2 2 2 2 Lrp/AsnC ligand binding domain NapD PF03927.13 AIF83318.1 - 0.0078 16.3 0.0 0.059 13.4 0.0 2.2 2 0 0 2 2 2 1 NapD protein DUF2250 PF10007.9 AIF83318.1 - 0.02 15.0 0.0 12 6.1 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) zf_UBZ PF18439.1 AIF83319.1 - 0.0079 15.8 0.3 0.0079 15.8 0.3 1.8 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger HTH_45 PF14947.6 AIF83320.1 - 4.9e-11 42.5 0.0 5.8e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIF83320.1 - 0.00064 19.5 0.0 0.00085 19.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) DUF1495 PF07381.11 AIF83320.1 - 0.0087 15.9 0.0 0.0098 15.7 0.0 1.3 1 1 0 1 1 1 1 Winged helix DNA-binding domain (DUF1495) PadR PF03551.14 AIF83320.1 - 0.014 15.3 0.2 0.019 14.9 0.2 1.2 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family PAX PF00292.18 AIF83320.1 - 0.029 14.3 0.0 0.031 14.2 0.0 1.1 1 0 0 1 1 1 0 'Paired box' domain HTH_34 PF13601.6 AIF83320.1 - 0.041 14.1 0.0 0.071 13.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain UPF0061 PF02696.14 AIF83321.1 - 0.018 13.8 0.3 0.021 13.6 0.3 1.1 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family CxxCxxCC PF03692.15 AIF83322.1 - 3.8e-09 37.1 0.0 8.6e-09 36.0 0.0 1.6 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain MJ1316 PF04457.12 AIF83323.1 - 0.0022 18.7 0.0 0.0027 18.4 0.0 1.2 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Aconitase_C PF00694.19 AIF83324.1 - 1.3e-21 77.3 0.0 2.3e-19 70.0 0.0 2.2 1 1 1 2 2 2 2 Aconitase C-terminal domain Aconitase_2_N PF06434.13 AIF83324.1 - 0.0035 17.0 0.1 0.015 14.9 0.1 1.9 1 1 0 1 1 1 1 Aconitate hydratase 2 N-terminus Aconitase PF00330.20 AIF83325.1 - 2.2e-93 313.8 7.1 4.3e-91 306.2 7.1 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) DUF521 PF04412.13 AIF83325.1 - 0.0056 15.5 0.1 0.0087 14.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF521) F420_ligase PF01996.16 AIF83326.1 - 1.6e-46 158.6 0.0 2e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase TMF_DNA_bd PF12329.8 AIF83327.1 - 0.0075 16.2 0.3 0.021 14.8 0.3 1.7 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding Peptidase_M50 PF02163.22 AIF83327.1 - 0.048 12.9 0.1 0.1 11.9 0.1 1.6 1 1 1 2 2 2 0 Peptidase family M50 DUF4250 PF14056.6 AIF83327.1 - 0.12 12.3 0.4 0.57 10.2 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4250) Zn_ribbon_recom PF13408.6 AIF83330.1 - 0.18 12.4 3.8 0.29 11.7 3.8 1.3 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain Zn_Tnp_IS1595 PF12760.7 AIF83330.1 - 0.21 11.6 3.4 0.33 10.9 3.4 1.3 1 1 0 1 1 1 0 Transposase zinc-ribbon domain HTH_45 PF14947.6 AIF83332.1 - 5e-19 68.1 0.9 5.9e-19 67.8 0.9 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIF83332.1 - 3.3e-05 23.7 0.1 3.7e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) PadR PF03551.14 AIF83332.1 - 0.06 13.3 0.1 0.097 12.6 0.1 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family Arg_decarbox_C PF17944.1 AIF83334.1 - 0.32 11.6 2.1 2.4 8.8 0.1 2.4 2 1 0 2 2 2 0 Arginine decarboxylase C-terminal helical extension HTH_45 PF14947.6 AIF83335.1 - 3.2e-16 59.1 0.1 4.4e-16 58.6 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix CAP PF00188.26 AIF83337.1 - 1.9e-16 61.0 0.5 3.9e-16 60.0 0.5 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DnaB_bind PF10410.9 AIF83338.1 - 0.13 12.4 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase NitrOD2 PF18550.1 AIF83339.1 - 1.6e-43 147.1 0.7 1.7e-43 147.0 0.7 1.0 1 0 0 1 1 1 1 Nitrososphaera output domain 2 DUF1376 PF07120.11 AIF83340.1 - 0.0082 16.4 0.1 0.012 15.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1376) HNH PF01844.23 AIF83342.1 - 0.00016 21.8 0.3 0.00024 21.2 0.3 1.4 1 0 0 1 1 1 1 HNH endonuclease HNH_3 PF13392.6 AIF83342.1 - 0.00041 20.1 0.0 0.00069 19.3 0.0 1.3 1 0 0 1 1 1 1 HNH endonuclease DZR PF12773.7 AIF83342.1 - 0.047 13.7 1.9 0.08 13.0 1.9 1.4 1 1 0 1 1 1 0 Double zinc ribbon DiS_P_DiS PF06750.13 AIF83342.1 - 0.055 13.6 0.6 0.62 10.2 0.1 2.1 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain Terminase_GpA PF05876.12 AIF83342.1 - 0.077 11.5 0.2 0.09 11.3 0.2 1.0 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) Zn-ribbon_8 PF09723.10 AIF83342.1 - 0.15 12.2 2.9 1.2 9.3 2.9 2.1 1 1 0 1 1 1 0 Zinc ribbon domain HypA PF01155.19 AIF83342.1 - 0.15 12.1 0.6 0.25 11.4 0.6 1.3 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Nudix_N_2 PF14803.6 AIF83342.1 - 0.23 11.4 2.9 9.1 6.3 0.1 2.3 2 0 0 2 2 2 0 Nudix N-terminal OpgC_C PF10129.9 AIF83344.1 - 0.0081 15.1 0.3 0.0089 14.9 0.3 1.0 1 0 0 1 1 1 1 OpgC protein AsnC_trans_reg PF01037.21 AIF83346.1 - 7.9e-13 48.2 0.1 1.3e-12 47.5 0.1 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 AIF83346.1 - 2.6e-09 36.5 0.5 4.7e-09 35.7 0.5 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF83346.1 - 9.2e-09 35.0 0.2 1.7e-08 34.1 0.2 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_20 PF12840.7 AIF83346.1 - 0.0024 17.9 0.0 0.0082 16.2 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain B-block_TFIIIC PF04182.12 AIF83346.1 - 0.0082 16.3 0.1 0.012 15.7 0.1 1.3 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_11 PF08279.12 AIF83346.1 - 0.013 15.4 0.3 0.033 14.1 0.3 1.7 1 0 0 1 1 1 0 HTH domain MarR PF01047.22 AIF83346.1 - 0.025 14.5 0.2 0.063 13.2 0.2 1.6 1 0 0 1 1 1 0 MarR family MarR_2 PF12802.7 AIF83346.1 - 0.041 13.8 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 MarR family TrmB PF01978.19 AIF83346.1 - 0.043 13.7 0.1 0.093 12.6 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Rrf2 PF02082.20 AIF83346.1 - 0.074 13.4 0.1 0.17 12.2 0.1 1.6 1 0 0 1 1 1 0 Transcriptional regulator Ribosomal_S25 PF03297.15 AIF83346.1 - 0.092 12.9 0.6 0.24 11.6 0.3 1.7 2 0 0 2 2 2 0 S25 ribosomal protein HxlR PF01638.17 AIF83347.1 - 2.2e-06 27.4 0.1 2.7e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_45 PF14947.6 AIF83347.1 - 0.00013 21.8 0.0 0.00024 21.0 0.0 1.5 1 1 0 1 1 1 1 Winged helix-turn-helix Replic_Relax PF13814.6 AIF83347.1 - 0.0038 17.3 0.1 0.005 16.9 0.1 1.2 1 0 0 1 1 1 1 Replication-relaxation PadR PF03551.14 AIF83347.1 - 0.0098 15.8 0.1 0.016 15.2 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family Cep3 PF16846.5 AIF83347.1 - 0.014 13.9 0.0 0.016 13.7 0.0 1.0 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B HTH_5 PF01022.20 AIF83347.1 - 0.014 15.2 0.0 2.8 7.9 0.0 2.5 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family HTH_34 PF13601.6 AIF83347.1 - 0.071 13.3 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_20 PF12840.7 AIF83347.1 - 0.087 12.9 0.0 0.18 11.9 0.0 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain SecE PF00584.20 AIF83349.1 - 0.012 15.5 0.0 0.013 15.4 0.0 1.1 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex SAM_4 PF18017.1 AIF83349.1 - 0.2 11.7 0.4 0.88 9.6 0.0 1.9 1 1 1 2 2 2 0 SAM domain (Sterile alpha motif) Thioredoxin PF00085.20 AIF83350.1 - 6.6e-31 106.4 0.0 7.4e-31 106.2 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AIF83350.1 - 8.2e-09 35.9 0.1 1.9e-07 31.5 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 AIF83350.1 - 7e-08 32.3 0.0 7.8e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 AIF83350.1 - 4e-07 30.3 0.0 0.00039 20.7 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_3 PF13192.6 AIF83350.1 - 1.2e-06 28.5 0.0 1.5e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_7 PF13899.6 AIF83350.1 - 2.9e-05 24.1 0.0 4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 AIF83350.1 - 0.00013 21.5 0.0 0.00013 21.5 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 AIF83350.1 - 0.0016 18.4 0.1 0.0082 16.1 0.1 1.8 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIF83350.1 - 0.0024 17.6 0.1 0.0046 16.7 0.1 1.5 1 1 0 1 1 1 1 Redoxin HyaE PF07449.11 AIF83350.1 - 0.004 17.1 0.0 0.0053 16.7 0.0 1.3 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_6 PF13848.6 AIF83350.1 - 0.042 13.8 0.0 0.055 13.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain DUF836 PF05768.14 AIF83350.1 - 0.065 13.7 0.0 0.084 13.3 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DUF452 PF04301.13 AIF83351.1 - 0.078 12.5 0.0 0.15 11.5 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF452) tRNA-synt_2c PF01411.19 AIF83352.1 - 4.6e-83 279.6 0.0 7.1e-83 279.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 AIF83352.1 - 5.9e-16 58.3 4.5 2.4e-15 56.3 1.5 2.8 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 AIF83352.1 - 8.6e-07 29.5 4.7 2.3e-06 28.1 4.7 1.8 1 0 0 1 1 1 1 DHHA1 domain YolD PF08863.10 AIF83352.1 - 0.071 13.2 0.1 0.32 11.1 0.0 2.2 2 0 0 2 2 2 0 YolD-like protein tRNA-synt_1 PF00133.22 AIF83353.1 - 1.4e-65 221.8 0.9 3.7e-64 217.0 0.9 2.7 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 AIF83353.1 - 1.1e-23 83.7 0.3 1.3e-11 44.0 0.1 3.2 2 1 1 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AIF83353.1 - 2.2e-22 79.7 0.3 6.3e-22 78.2 0.3 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 AIF83353.1 - 2.3e-13 50.2 0.1 3e-08 33.4 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.6 AIF83353.1 - 2.4e-12 46.8 0.0 6.4e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 STI1 PF17830.1 AIF83353.1 - 9.1e-05 22.3 0.4 0.00029 20.7 0.4 1.9 1 0 0 1 1 1 1 STI1 domain NmrA PF05368.13 AIF83354.1 - 3.3e-20 72.7 0.2 4.4e-20 72.2 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 AIF83354.1 - 2.7e-16 60.0 0.3 4e-16 59.4 0.3 1.4 1 1 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 AIF83354.1 - 0.0001 22.6 0.3 0.00027 21.2 0.1 1.9 2 1 0 2 2 2 1 TrkA-N domain Epimerase PF01370.21 AIF83354.1 - 0.00079 18.9 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 AIF83354.1 - 0.0019 18.8 0.4 0.0078 16.8 0.0 2.3 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 AIF83354.1 - 0.005 17.0 0.1 0.019 15.2 0.0 1.9 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase adh_short PF00106.25 AIF83354.1 - 0.01 15.3 0.4 0.046 13.2 0.1 2.1 1 1 1 2 2 2 0 short chain dehydrogenase ApbA PF02558.16 AIF83354.1 - 0.018 14.7 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA KR PF08659.10 AIF83354.1 - 0.058 13.3 0.2 0.16 11.8 0.2 1.8 1 1 0 1 1 1 0 KR domain CoA_binding_2 PF13380.6 AIF83354.1 - 0.076 13.5 0.1 0.58 10.7 0.0 2.3 2 1 0 2 2 2 0 CoA binding domain HTH_24 PF13412.6 AIF83355.1 - 3.2e-22 77.8 2.4 2.8e-10 39.6 0.1 3.0 3 0 0 3 3 3 2 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF83355.1 - 1e-20 73.3 0.1 1.3e-09 37.7 0.0 2.5 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain MarR PF01047.22 AIF83355.1 - 2.1e-06 27.6 0.1 0.00012 22.0 0.0 2.5 2 0 0 2 2 2 1 MarR family TrmB PF01978.19 AIF83355.1 - 9.9e-05 22.1 0.0 0.027 14.3 0.0 2.7 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 AIF83355.1 - 0.00022 21.1 0.0 0.0021 17.9 0.0 2.4 2 0 0 2 2 2 1 HTH domain HTH_5 PF01022.20 AIF83355.1 - 0.00069 19.4 0.3 0.003 17.4 0.1 2.2 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_Mga PF08280.11 AIF83355.1 - 0.0021 18.0 0.0 0.0083 16.1 0.0 1.9 2 0 0 2 2 2 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_20 PF12840.7 AIF83355.1 - 0.0022 18.0 0.0 0.5 10.5 0.0 2.6 3 0 0 3 3 2 1 Helix-turn-helix domain HTH_9 PF08221.11 AIF83355.1 - 0.0041 17.2 0.8 0.35 11.0 0.1 2.8 3 0 0 3 3 3 1 RNA polymerase III subunit RPC82 helix-turn-helix domain MarR_2 PF12802.7 AIF83355.1 - 0.0053 16.6 0.0 0.93 9.4 0.0 2.4 2 0 0 2 2 2 1 MarR family TFIIE_alpha PF02002.17 AIF83355.1 - 0.012 15.4 0.3 0.055 13.3 0.1 2.3 3 0 0 3 3 3 0 TFIIE alpha subunit HTH_IclR PF09339.10 AIF83355.1 - 0.014 15.2 0.0 0.035 13.9 0.0 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain Sigma70_r4_2 PF08281.12 AIF83355.1 - 0.017 14.7 0.6 0.64 9.7 0.2 2.6 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.6 AIF83355.1 - 0.026 14.3 0.1 1.1 9.1 0.0 2.6 2 0 0 2 2 2 0 Homeodomain-like domain Sigma70_r4 PF04545.16 AIF83355.1 - 0.074 12.6 0.3 2.4 7.8 0.1 2.6 2 0 0 2 2 2 0 Sigma-70, region 4 GerE PF00196.19 AIF83355.1 - 0.075 12.6 0.0 0.2 11.2 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_10 PF04967.12 AIF83355.1 - 0.091 12.6 0.1 2.5 8.0 0.1 2.3 2 0 0 2 2 2 0 HTH DNA binding domain HTH_36 PF13730.6 AIF83355.1 - 0.093 12.7 0.2 8.2 6.5 0.1 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 AIF83355.1 - 0.097 12.9 0.4 0.69 10.2 0.0 2.5 3 0 0 3 3 3 0 Transposase Mga PF05043.13 AIF83355.1 - 0.13 12.8 0.0 0.87 10.2 0.0 2.1 2 0 0 2 2 2 0 Mga helix-turn-helix domain HTH_28 PF13518.6 AIF83355.1 - 0.15 12.2 0.0 7.3 6.8 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain DUF202 PF02656.15 AIF83356.1 - 0.35 11.3 3.2 0.45 11.0 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Gram_pos_anchor PF00746.21 AIF83356.1 - 1.3 9.0 5.6 8.3 6.5 0.8 2.2 2 0 0 2 2 2 0 LPXTG cell wall anchor motif LapA_dom PF06305.11 AIF83356.1 - 1.5 8.7 3.6 12 5.8 0.4 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF3040 PF11239.8 AIF83356.1 - 1.9 8.8 6.6 2.4 8.5 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Pyr_redox_2 PF07992.14 AIF83357.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyoxalase PF00903.25 AIF83358.1 - 0.002 18.3 0.0 0.0031 17.7 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AIF83358.1 - 0.0096 16.7 0.0 0.018 15.8 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain DUF1428 PF07237.11 AIF83359.1 - 6.1e-07 29.7 0.0 7.5e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1428) Prefoldin PF02996.17 AIF83360.1 - 1e-17 64.2 6.8 3.7e-17 62.4 6.8 1.8 1 1 0 1 1 1 1 Prefoldin subunit Halogen_Hydrol PF10112.9 AIF83360.1 - 0.0018 18.3 5.4 0.019 15.0 0.2 2.1 1 1 1 2 2 2 1 5-bromo-4-chloroindolyl phosphate hydrolysis protein Prefoldin_2 PF01920.20 AIF83360.1 - 0.0021 18.0 3.7 0.0021 18.0 3.7 2.5 1 1 2 3 3 3 1 Prefoldin subunit Methyltransf_14 PF08484.11 AIF83360.1 - 0.004 17.0 1.1 0.026 14.4 0.0 2.0 2 0 0 2 2 2 1 C-methyltransferase C-terminal domain FlaC_arch PF05377.11 AIF83360.1 - 0.015 15.7 1.6 0.015 15.7 1.6 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) FAP206 PF12018.8 AIF83360.1 - 0.024 14.2 3.7 0.93 8.9 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function Host_attach PF10116.9 AIF83360.1 - 0.03 14.9 2.9 0.061 13.9 2.9 1.5 1 0 0 1 1 1 0 Protein required for attachment to host cells DUF948 PF06103.11 AIF83360.1 - 0.051 13.8 2.7 1.4 9.2 0.3 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) YlqD PF11068.8 AIF83360.1 - 0.065 13.6 11.9 0.061 13.7 4.6 2.2 2 0 0 2 2 2 0 YlqD protein Zip PF02535.22 AIF83360.1 - 0.073 12.3 1.0 0.061 12.5 1.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter EMP24_GP25L PF01105.24 AIF83360.1 - 0.21 11.5 2.9 1 9.3 0.2 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF4140 PF13600.6 AIF83360.1 - 0.43 11.0 4.4 1.2 9.6 1.7 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF1178 PF06676.11 AIF83360.1 - 0.52 10.7 6.6 0.16 12.4 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) ABC_tran_Xtn PF12848.7 AIF83360.1 - 1.2 9.2 13.0 0.87 9.7 7.5 2.2 2 0 0 2 2 2 0 ABC transporter DUF4199 PF13858.6 AIF83360.1 - 1.8 8.9 6.0 1.5 9.2 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) SelP_N PF04592.14 AIF83360.1 - 2.8 7.3 15.9 5.2 6.4 15.9 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF16 PF01519.16 AIF83360.1 - 2.8 8.5 7.7 2.3 8.7 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF4055 PF13264.6 AIF83360.1 - 4 7.6 10.2 0.13 12.4 1.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4055) SRP54 PF00448.22 AIF83361.1 - 6.2e-69 231.6 0.4 8.9e-69 231.1 0.4 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 AIF83361.1 - 8.3e-09 35.5 6.9 8.3e-09 35.5 6.9 2.4 3 0 0 3 3 2 1 SRP54-type protein, helical bundle domain AAA_30 PF13604.6 AIF83361.1 - 6.9e-06 25.9 0.6 1.5e-05 24.8 0.6 1.5 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 AIF83361.1 - 0.00042 20.3 0.1 0.0011 18.8 0.1 1.7 1 0 0 1 1 1 1 Adenylylsulphate kinase KdpD PF02702.17 AIF83361.1 - 0.00091 18.8 0.1 0.002 17.7 0.1 1.6 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain AAA_22 PF13401.6 AIF83361.1 - 0.0024 18.1 0.0 0.0073 16.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 AIF83361.1 - 0.0068 16.0 0.1 0.015 14.9 0.1 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 AIF83361.1 - 0.0085 16.1 0.0 0.019 15.0 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Thymidylate_kin PF02223.17 AIF83361.1 - 0.011 15.4 0.0 0.011 15.4 0.0 2.8 2 1 0 2 2 1 0 Thymidylate kinase MeaB PF03308.16 AIF83361.1 - 0.016 14.2 0.8 0.064 12.2 0.3 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 AIF83361.1 - 0.017 15.5 0.1 0.017 15.5 0.1 2.2 2 1 1 3 3 2 0 AAA ATPase domain AAA PF00004.29 AIF83361.1 - 0.058 13.8 0.2 0.16 12.4 0.2 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AIF_C PF14721.6 AIF83361.1 - 2.3 8.6 12.3 3.6 8.0 10.4 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DDHD PF02862.17 AIF83361.1 - 3.3 7.8 6.5 33 4.5 7.2 2.1 2 0 0 2 2 2 0 DDHD domain OTCace_N PF02729.21 AIF83362.1 - 2.2e-53 180.2 0.0 3.5e-53 179.6 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 AIF83362.1 - 2.8e-53 180.2 0.0 4.1e-53 179.7 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain SNARE_assoc PF09335.11 AIF83363.1 - 2.8e-19 69.8 6.8 2.8e-19 69.8 6.8 2.4 2 1 1 3 3 3 1 SNARE associated Golgi protein FixQ PF05545.11 AIF83363.1 - 0.0062 16.5 1.6 0.011 15.7 0.0 2.3 2 0 0 2 2 2 1 Cbb3-type cytochrome oxidase component FixQ Gram_pos_anchor PF00746.21 AIF83363.1 - 0.49 10.4 0.1 0.49 10.4 0.1 4.2 4 0 0 4 4 4 0 LPXTG cell wall anchor motif DUF763 PF05559.11 AIF83364.1 - 1e-124 415.8 0.0 1.3e-124 415.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF763) Rieske PF00355.26 AIF83365.1 - 1.1e-17 63.8 0.0 1.3e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIF83365.1 - 1.5e-06 28.1 0.0 1.9e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Thiamine_BP PF01910.17 AIF83366.1 - 5.1e-23 80.8 2.2 5.8e-23 80.6 2.2 1.0 1 0 0 1 1 1 1 Thiamine-binding protein DOT1 PF08123.13 AIF83367.1 - 1.8e-09 37.4 0.1 3.1e-08 33.4 0.1 2.2 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 AIF83367.1 - 2e-07 31.6 0.1 3.7e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF83367.1 - 1.2e-05 25.9 0.0 2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AIF83367.1 - 3e-05 23.5 0.0 4e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 AIF83367.1 - 0.00014 21.4 0.2 0.00019 21.0 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 AIF83367.1 - 0.0002 21.2 0.1 0.0003 20.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 AIF83367.1 - 0.00061 19.3 0.0 0.00091 18.7 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.19 AIF83367.1 - 0.018 15.2 0.0 0.027 14.6 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 AIF83367.1 - 0.019 14.7 0.1 0.041 13.6 0.1 1.5 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 AIF83367.1 - 0.027 14.0 0.0 0.071 12.6 0.1 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_18 PF12847.7 AIF83367.1 - 0.048 13.6 0.1 0.076 12.9 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase domain PEPCK_ATP PF01293.20 AIF83371.1 - 3.4e-220 731.6 0.0 3.9e-220 731.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase PSD1 PF07587.11 AIF83371.1 - 0.0024 17.4 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1553) AAA_33 PF13671.6 AIF83371.1 - 0.19 11.9 0.0 0.36 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain UbiA PF01040.18 AIF83373.1 - 7.4e-38 130.3 16.0 1e-37 129.8 16.0 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Trp_oprn_chp PF09534.10 AIF83373.1 - 0.45 10.3 3.0 0.43 10.3 1.5 1.7 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Regulator_TrmB PF11495.8 AIF83374.1 - 0.0006 19.1 0.9 0.011 14.9 0.9 2.1 1 1 0 1 1 1 1 Archaeal transcriptional regulator TrmB TrmB PF01978.19 AIF83374.1 - 0.00063 19.6 0.1 0.0019 18.1 0.1 1.8 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB PLDc_2 PF13091.6 AIF83374.1 - 0.00097 19.0 0.0 0.0017 18.3 0.0 1.5 1 0 0 1 1 1 1 PLD-like domain HTH_20 PF12840.7 AIF83374.1 - 0.022 14.8 0.1 0.18 11.9 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_45 PF14947.6 AIF83374.1 - 0.025 14.6 0.5 0.068 13.2 0.1 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix Terminase_3 PF04466.13 AIF83374.1 - 0.42 10.1 3.4 0.24 10.9 0.7 2.0 2 1 0 2 2 2 0 Phage terminase large subunit CxxCxxCC PF03692.15 AIF83376.1 - 2.9e-08 34.3 0.3 1e-07 32.6 0.3 1.9 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain Phage_int_SAM_6 PF18644.1 AIF83377.1 - 0.091 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Phage integrase SAM-like domain DUF711 PF05167.12 AIF83377.1 - 0.15 11.0 0.0 0.22 10.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised ACR (DUF711) LAGLIDADG_3 PF14528.6 AIF83378.1 - 3.1e-15 56.2 0.1 2.2e-14 53.5 0.0 2.1 2 0 0 2 2 2 1 LAGLIDADG-like domain LAGLIDADG_1 PF00961.19 AIF83378.1 - 2.5e-05 25.2 0.9 0.00018 22.4 0.4 2.1 2 0 0 2 2 2 1 LAGLIDADG endonuclease WhiA_N PF10298.9 AIF83378.1 - 0.014 15.4 0.1 0.039 14.0 0.1 1.9 1 0 0 1 1 1 0 WhiA N-terminal LAGLIDADG-like domain LAGLIDADG_WhiA PF14527.6 AIF83378.1 - 0.017 15.2 0.3 1.7 8.7 0.0 2.8 2 1 1 3 3 3 0 WhiA LAGLIDADG-like domain Sod_Fe_C PF02777.18 AIF83379.1 - 1.2e-38 131.4 0.6 2.2e-38 130.5 0.6 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 AIF83379.1 - 4.6e-29 100.7 1.1 4.6e-29 100.7 1.1 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain SpaA PF17802.1 AIF83380.1 - 9.1e-06 25.9 0.2 3.2e-05 24.2 0.1 2.0 2 0 0 2 2 2 1 Prealbumin-like fold domain PPC PF04151.15 AIF83381.1 - 0.0035 18.4 0.5 0.023 15.8 0.2 2.6 2 0 0 2 2 2 1 Bacterial pre-peptidase C-terminal domain DUF4975 PF16346.5 AIF83381.1 - 0.049 13.7 0.1 0.091 12.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4975) Nitroreductase PF00881.24 AIF83383.1 - 3.3e-31 108.6 3.7 5.4e-30 104.7 3.7 2.0 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 AIF83383.1 - 1.2e-10 41.3 0.2 1.2e-05 25.0 0.2 3.0 1 1 2 3 3 3 3 Putative TM nitroreductase HMG_CoA_synt_C PF08540.10 AIF83384.1 - 2.7e-33 115.8 0.1 4.9e-33 114.9 0.1 1.4 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 AIF83384.1 - 7.6e-29 100.8 0.0 1.9e-28 99.5 0.0 1.6 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal PALP PF00291.25 AIF83385.1 - 1.3e-87 294.0 2.9 1.6e-87 293.6 2.9 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT PF01842.25 AIF83385.1 - 0.00056 19.6 0.0 0.0013 18.4 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 AIF83385.1 - 0.015 15.9 0.0 0.035 14.7 0.0 1.6 1 0 0 1 1 1 0 ACT domain Thr_dehydrat_C PF00585.18 AIF83385.1 - 0.15 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase Rhomboid_N PF12122.8 AIF83385.1 - 0.16 12.2 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Cytoplasmic N-terminal domain of rhomboid serine protease DUF2024 PF09630.10 AIF83386.1 - 2.1e-35 120.5 1.7 2.3e-35 120.3 1.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2024) Lactamase_B PF00753.27 AIF83387.1 - 6.4e-21 75.3 2.4 1.2e-20 74.3 2.3 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AIF83387.1 - 0.0016 18.0 0.3 0.003 17.1 0.2 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Response_reg PF00072.24 AIF83388.1 - 9.3e-07 29.0 0.0 8.3e-06 25.9 0.0 2.0 1 1 0 1 1 1 1 Response regulator receiver domain TFA2_Winged_2 PF18121.1 AIF83388.1 - 0.24 11.1 0.9 2.5 7.9 0.4 2.4 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 HTH_24 PF13412.6 AIF83390.1 - 1.1e-08 34.5 0.5 1.1e-08 34.5 0.5 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding CENP-B_N PF04218.13 AIF83390.1 - 0.00057 19.5 1.1 0.0084 15.7 0.1 2.3 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_AsnC-type PF13404.6 AIF83390.1 - 0.0017 18.2 0.6 0.0048 16.7 0.6 1.8 1 1 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.12 AIF83390.1 - 0.0026 17.7 1.1 0.0047 16.9 0.3 1.8 2 0 0 2 2 2 1 HTH domain HTH_20 PF12840.7 AIF83390.1 - 0.0032 17.5 0.2 0.0069 16.4 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain Fe_dep_repress PF01325.19 AIF83390.1 - 0.0035 17.5 0.2 0.011 15.9 0.0 1.9 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain Rrf2 PF02082.20 AIF83390.1 - 0.0055 17.0 0.1 0.013 15.9 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulator HTH_23 PF13384.6 AIF83390.1 - 0.0063 16.3 0.1 0.012 15.4 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain MarR PF01047.22 AIF83390.1 - 0.0088 15.9 0.3 0.041 13.8 0.0 2.0 2 0 0 2 2 2 1 MarR family Put_DNA-bind_N PF06971.13 AIF83390.1 - 0.011 15.8 0.0 0.03 14.3 0.0 1.7 1 0 0 1 1 1 0 Putative DNA-binding protein N-terminus Sigma70_r4_2 PF08281.12 AIF83390.1 - 0.014 15.0 0.1 0.035 13.8 0.1 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_6 PF01418.17 AIF83390.1 - 0.018 15.0 0.3 0.047 13.7 0.1 1.8 2 0 0 2 2 1 0 Helix-turn-helix domain, rpiR family GerE PF00196.19 AIF83390.1 - 0.024 14.2 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family RP-C PF03428.13 AIF83390.1 - 0.041 13.5 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 Replication protein C N-terminal domain HTH_IclR PF09339.10 AIF83390.1 - 0.049 13.4 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain Dimerisation PF08100.11 AIF83390.1 - 0.05 13.6 0.1 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 Dimerisation domain GntR PF00392.21 AIF83390.1 - 0.056 13.1 0.1 0.12 12.0 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_5 PF01022.20 AIF83390.1 - 0.057 13.3 0.2 0.16 11.9 0.0 2.0 2 0 0 2 2 1 0 Bacterial regulatory protein, arsR family HTH_Crp_2 PF13545.6 AIF83390.1 - 0.059 13.3 0.1 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain MarR_2 PF12802.7 AIF83390.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 MarR family TrmB PF01978.19 AIF83390.1 - 0.13 12.2 0.2 0.36 10.7 0.0 1.8 2 0 0 2 2 1 0 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.6 AIF83391.1 - 0.068 13.0 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_24 PF13412.6 AIF83393.1 - 2e-08 33.6 0.4 4.4e-08 32.6 0.1 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF83393.1 - 3e-08 33.3 0.1 5.9e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.12 AIF83393.1 - 4.1e-05 23.4 0.2 0.00013 21.9 0.2 1.8 1 0 0 1 1 1 1 HTH domain HTH_23 PF13384.6 AIF83393.1 - 0.0011 18.7 0.0 0.0023 17.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain AsnC_trans_reg PF01037.21 AIF83393.1 - 0.0079 16.1 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain Put_DNA-bind_N PF06971.13 AIF83393.1 - 0.017 15.1 0.0 0.045 13.8 0.0 1.7 1 0 0 1 1 1 0 Putative DNA-binding protein N-terminus HTH_20 PF12840.7 AIF83393.1 - 0.035 14.2 0.0 0.3 11.2 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain MarR_2 PF12802.7 AIF83393.1 - 0.045 13.6 0.1 0.099 12.6 0.1 1.5 1 0 0 1 1 1 0 MarR family HTH_IclR PF09339.10 AIF83393.1 - 0.062 13.1 0.0 0.23 11.3 0.0 1.9 2 0 0 2 2 2 0 IclR helix-turn-helix domain Sigma70_r4_2 PF08281.12 AIF83393.1 - 0.085 12.5 0.3 0.23 11.2 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 GntR PF00392.21 AIF83393.1 - 0.092 12.4 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family TrmB PF01978.19 AIF83393.1 - 0.098 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_Tnp_ISL3 PF13542.6 AIF83393.1 - 0.11 11.9 0.0 0.43 10.0 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 DUF5083 PF16890.5 AIF83394.1 - 0.0052 16.5 1.8 0.0059 16.4 1.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5083) NHL PF01436.21 AIF83395.1 - 3.3e-27 93.1 0.0 0.0051 16.8 0.0 7.5 7 0 0 7 7 7 6 NHL repeat Thioredoxin_8 PF13905.6 AIF83395.1 - 1.3e-13 51.0 0.0 2.6e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 AIF83395.1 - 2.1e-12 47.0 0.0 1.4e-11 44.3 0.0 2.2 2 0 0 2 2 2 1 Redoxin AhpC-TSA PF00578.21 AIF83395.1 - 1.1e-11 44.8 0.1 3.1e-11 43.2 0.0 1.8 3 0 0 3 3 3 1 AhpC/TSA family SGL PF08450.12 AIF83395.1 - 4.7e-07 29.6 0.5 0.005 16.5 0.0 3.7 4 0 0 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region ANAPC4_WD40 PF12894.7 AIF83395.1 - 3.5e-06 27.2 0.4 0.0044 17.3 0.0 4.5 6 0 0 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Thioredoxin PF00085.20 AIF83395.1 - 1.3e-05 25.1 0.5 0.038 14.0 0.1 2.7 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_2 PF13098.6 AIF83395.1 - 5e-05 23.7 0.0 9.1e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain LVIVD PF08309.11 AIF83395.1 - 0.00022 20.5 0.0 0.56 9.6 0.0 4.1 4 0 0 4 4 4 1 LVIVD repeat TrbC_Ftype PF09673.10 AIF83395.1 - 0.024 14.7 0.0 0.045 13.8 0.0 1.3 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein YtfJ_HI0045 PF09695.10 AIF83395.1 - 0.027 14.1 0.1 0.098 12.3 0.1 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (YtfJ_HI0045) PQQ_3 PF13570.6 AIF83395.1 - 0.045 14.3 0.3 1.5e+02 3.1 0.0 4.5 4 0 0 4 4 4 0 PQQ-like domain Phytase-like PF13449.6 AIF83395.1 - 0.076 12.9 0.0 1.1 9.1 0.0 2.5 3 0 0 3 3 3 0 Esterase-like activity of phytase Nitroreductase PF00881.24 AIF83396.1 - 2.2e-22 79.9 0.2 7.8e-11 42.3 0.0 2.1 1 1 1 2 2 2 2 Nitroreductase family TM1586_NiRdase PF14512.6 AIF83396.1 - 2.8e-09 36.9 0.0 0.00048 19.8 0.0 2.1 2 0 0 2 2 2 2 Putative TM nitroreductase HCV_NS5a_C PF12941.7 AIF83396.1 - 0.017 15.0 0.0 0.023 14.5 0.0 1.1 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region DUF432 PF04254.13 AIF83397.1 - 2.8e-32 111.5 0.2 4.1e-32 110.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF432) CorA PF01544.18 AIF83398.1 - 1.1e-58 198.9 0.1 1.2e-58 198.7 0.1 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein TelA PF05816.11 AIF83398.1 - 0.07 12.2 0.6 0.13 11.3 0.3 1.5 1 1 0 1 1 1 0 Toxic anion resistance protein (TelA) FeoB_Cyto PF17910.1 AIF83398.1 - 0.096 13.2 0.3 2.4 8.7 0.0 2.4 2 0 0 2 2 2 0 FeoB cytosolic helical domain DegS PF05384.11 AIF83398.1 - 0.47 9.9 3.7 1.4 8.4 2.2 2.4 2 1 1 3 3 3 0 Sensor protein DegS MS_channel PF00924.18 AIF83399.1 - 7.1e-50 169.4 0.4 7.1e-50 169.4 0.4 1.6 2 0 0 2 2 2 1 Mechanosensitive ion channel MFS_1 PF07690.16 AIF83400.1 - 2.5e-30 105.6 41.9 4.9e-19 68.5 16.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Guanylate_cyc PF00211.20 AIF83402.1 - 5.3e-18 65.3 0.1 7.6e-18 64.8 0.1 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF3535 PF12054.8 AIF83402.1 - 0.018 14.3 0.1 0.024 13.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) Ribosomal_S9 PF00380.19 AIF83403.1 - 6e-28 97.8 0.4 7e-28 97.6 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13 PF00572.18 AIF83404.1 - 2.6e-10 40.6 0.8 2.1e-08 34.4 0.8 2.1 1 1 0 1 1 1 1 Ribosomal protein L13 Ribosomal_L18 PF17135.4 AIF83405.1 - 7.2e-11 41.8 0.0 7.8e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 AIF83405.1 - 4.4e-08 33.9 0.2 6.3e-08 33.3 0.2 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_L1 PF00687.21 AIF83405.1 - 0.0089 15.8 0.0 0.012 15.4 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family RNA_pol_A_bac PF01000.26 AIF83406.1 - 2.7e-27 95.4 0.0 5.9e-27 94.3 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AIF83406.1 - 4.9e-14 51.5 0.0 7.3e-14 51.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SBDS PF01172.18 AIF83407.1 - 7.9e-21 73.9 0.0 1.2e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 AIF83407.1 - 7.1e-17 61.5 0.0 1.1e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 SBDS protein C-terminal domain DUF3095 PF11294.8 AIF83407.1 - 0.023 13.8 0.0 0.064 12.3 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3095) Phage_TAC_5 PF08890.11 AIF83407.1 - 0.09 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Phage XkdN-like tail assembly chaperone protein, TAC DNA_binding_1 PF01035.20 AIF83408.1 - 6.2e-32 109.6 3.8 1.3e-31 108.5 0.4 2.7 2 1 1 3 3 3 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Ada_Zn_binding PF02805.16 AIF83408.1 - 1.5e-29 101.8 4.8 3.4e-29 100.6 4.8 1.7 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_18 PF12833.7 AIF83408.1 - 1.8e-20 73.0 0.8 1.2e-19 70.4 0.5 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 AIF83408.1 - 2.6e-15 56.0 0.0 1.6e-08 34.4 0.0 3.2 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Methyltransf_1N PF02870.15 AIF83408.1 - 0.0036 18.1 0.0 0.0089 16.8 0.0 1.7 2 0 0 2 2 2 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain KH_1 PF00013.29 AIF83410.1 - 3.8e-10 39.4 2.1 7.4e-10 38.5 2.1 1.4 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 AIF83410.1 - 0.00026 20.7 1.3 0.00072 19.3 1.1 1.9 1 1 1 2 2 2 1 KH domain KH_6 PF15985.5 AIF83410.1 - 0.025 14.9 0.0 0.041 14.2 0.0 1.4 1 0 0 1 1 1 0 KH domain RNase_PH PF01138.21 AIF83411.1 - 4.3e-34 117.9 0.0 6e-34 117.4 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AIF83411.1 - 4.1e-14 52.4 0.7 1.3e-13 50.7 0.2 2.1 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 RNase_PH PF01138.21 AIF83412.1 - 1.3e-27 96.9 0.0 2.2e-27 96.2 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AIF83412.1 - 1.7e-07 31.2 0.1 5.7e-07 29.5 0.0 1.9 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Ribosomal_L37ae PF01780.19 AIF83413.1 - 5.8e-16 58.4 1.1 5.9e-16 58.3 1.1 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 AIF83413.1 - 3.1e-05 23.9 3.3 4.6e-05 23.3 3.3 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 AIF83413.1 - 0.0036 16.7 1.4 0.075 12.5 0.1 2.3 2 0 0 2 2 2 1 zinc-ribbon domain C1_1 PF00130.22 AIF83413.1 - 0.036 14.0 0.8 0.053 13.4 0.8 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-tcix PF14952.6 AIF83413.1 - 0.043 13.4 3.3 1.7 8.3 0.4 2.2 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding OrfB_Zn_ribbon PF07282.11 AIF83413.1 - 0.047 13.6 0.7 0.063 13.2 0.7 1.4 1 1 0 1 1 1 0 Putative transposase DNA-binding domain Rubredoxin PF00301.20 AIF83413.1 - 0.058 13.4 0.6 5.4 7.1 0.3 2.2 2 0 0 2 2 2 0 Rubredoxin zf-RanBP PF00641.18 AIF83413.1 - 0.063 12.6 3.9 0.33 10.3 0.6 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others VP_N-CPKC PF11475.8 AIF83413.1 - 0.09 12.7 1.7 1.6 8.7 0.2 2.2 2 0 0 2 2 2 0 Virion protein N terminal domain TackOD1 PF18551.1 AIF83413.1 - 0.097 12.3 0.4 0.19 11.4 0.4 1.5 1 1 0 1 1 1 0 Thaumarchaeal output domain 1 DUF35_N PF12172.8 AIF83413.1 - 0.2 11.6 3.4 0.24 11.3 0.3 2.0 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-C4_Topoisom PF01396.19 AIF83413.1 - 0.26 11.1 3.6 6 6.7 0.1 2.7 3 0 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger zinc_ribbon_2 PF13240.6 AIF83413.1 - 0.47 10.2 4.2 12 5.7 1.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 AIF83413.1 - 0.53 10.4 5.0 0.54 10.4 0.2 2.2 1 1 1 2 2 2 0 Zinc ribbon domain DNA_ligase_ZBD PF03119.16 AIF83413.1 - 4.5 7.4 7.8 1.9 8.6 0.7 2.6 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Rubredoxin_2 PF18073.1 AIF83413.1 - 8.4 6.2 9.2 13 5.6 1.6 2.6 3 0 0 3 3 3 0 Rubredoxin metal binding domain Pcc1 PF09341.10 AIF83414.1 - 1.1e-09 38.2 0.0 1.2e-09 38.1 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 Prefoldin_2 PF01920.20 AIF83415.1 - 8.7e-22 77.1 14.6 9.7e-22 76.9 14.6 1.0 1 0 0 1 1 1 1 Prefoldin subunit AbiEi_3 PF11459.8 AIF83415.1 - 0.066 12.9 1.4 0.081 12.6 1.4 1.2 1 1 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system DUF919 PF06034.11 AIF83415.1 - 0.068 13.0 0.9 0.068 13.0 0.9 2.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF2408 PF10303.9 AIF83415.1 - 0.15 12.6 5.9 0.21 12.1 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Prefoldin PF02996.17 AIF83415.1 - 0.48 10.4 10.5 0.52 10.2 1.5 2.1 1 1 1 2 2 2 0 Prefoldin subunit Nup88 PF10168.9 AIF83415.1 - 0.64 7.8 10.4 0.77 7.5 10.4 1.0 1 0 0 1 1 1 0 Nuclear pore component YabA PF06156.13 AIF83415.1 - 1.6 9.4 9.4 1.9 9.2 2.5 2.2 1 1 0 2 2 2 0 Initiation control protein YabA KIP1 PF07765.12 AIF83415.1 - 2.2 8.5 7.4 11 6.2 0.1 2.8 2 1 1 3 3 3 0 KIP1-like protein DUF2175 PF09943.9 AIF83415.1 - 8.6 6.7 10.5 4.2 7.7 3.1 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) ERCC4 PF02732.15 AIF83416.1 - 6.1e-21 75.3 0.0 8.4e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.6 AIF83416.1 - 1.4e-11 44.8 0.2 4.3e-10 40.1 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_2 PF12826.7 AIF83416.1 - 5.4e-05 23.2 0.0 0.00013 22.0 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH PF00633.23 AIF83416.1 - 0.00021 21.0 0.1 0.78 9.7 0.0 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif IMS_HHH PF11798.8 AIF83416.1 - 0.005 17.1 0.0 0.066 13.6 0.0 2.4 2 0 0 2 2 2 1 IMS family HHH motif HHH_3 PF12836.7 AIF83416.1 - 0.0057 16.9 0.1 3.3 8.0 0.0 2.4 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_8 PF14716.6 AIF83416.1 - 0.0084 16.5 0.0 1.7 9.1 0.0 3.1 2 1 1 3 3 3 2 Helix-hairpin-helix domain 5_3_exonuc PF01367.20 AIF83416.1 - 0.01 16.4 0.1 0.11 13.0 0.0 2.3 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.16 AIF83416.1 - 0.03 14.6 0.0 0.34 11.2 0.0 2.5 1 1 1 2 2 2 0 Transposase IS116/IS110/IS902 family EspB_PE PF18625.1 AIF83416.1 - 0.053 14.0 0.2 0.13 12.7 0.2 1.6 1 0 0 1 1 1 0 ESX-1 secreted protein B PE domain DUF3701 PF12482.8 AIF83416.1 - 0.12 12.5 0.0 6.4 6.9 0.0 2.4 1 1 1 2 2 2 0 Phage integrase protein PHA_synth_III_E PF09712.10 AIF83416.1 - 0.21 10.7 0.0 0.3 10.1 0.0 1.2 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) Rhodanese PF00581.20 AIF83417.1 - 1.7e-33 115.3 0.1 7.4e-16 58.6 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain PIN_6 PF17146.4 AIF83418.1 - 2.4e-16 60.0 0.4 4.1e-16 59.2 0.4 1.3 1 0 0 1 1 1 1 PIN domain of ribonuclease PIN PF01850.21 AIF83418.1 - 0.00016 22.2 3.8 0.00028 21.4 3.8 1.5 1 1 0 1 1 1 1 PIN domain NOB1_Zn_bind PF08772.11 AIF83418.1 - 0.00089 19.4 1.1 0.0014 18.7 1.1 1.3 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like HypA PF01155.19 AIF83418.1 - 0.0049 16.9 0.6 0.0086 16.1 0.5 1.5 1 1 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 AIF83418.1 - 0.0053 16.1 1.8 0.012 15.0 1.8 1.6 1 0 0 1 1 1 1 zinc-ribbon domain PIN_5 PF08745.11 AIF83418.1 - 0.0077 15.7 0.2 0.016 14.6 0.2 1.5 2 0 0 2 2 2 1 PINc domain ribonuclease DZR PF12773.7 AIF83418.1 - 0.012 15.6 0.9 0.02 14.9 0.9 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 AIF83418.1 - 0.031 14.1 0.9 0.051 13.4 0.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Nudix_N_2 PF14803.6 AIF83418.1 - 0.044 13.7 1.8 6.1 6.9 0.2 2.3 2 0 0 2 2 2 0 Nudix N-terminal Zn-ribbon_8 PF09723.10 AIF83418.1 - 0.053 13.6 2.2 0.16 12.1 2.2 1.8 1 1 0 1 1 1 0 Zinc ribbon domain DUF35_N PF12172.8 AIF83418.1 - 0.064 13.2 1.8 0.077 12.9 0.6 1.7 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) RecR PF02132.15 AIF83418.1 - 0.096 12.3 0.1 0.22 11.1 0.1 1.6 1 0 0 1 1 1 0 RecR protein FdhE PF04216.12 AIF83418.1 - 0.19 11.6 3.5 0.44 10.4 3.4 1.7 1 1 0 1 1 1 0 Protein involved in formate dehydrogenase formation zf-BED PF02892.15 AIF83418.1 - 0.23 11.5 1.8 14 5.8 0.1 2.3 1 1 1 2 2 2 0 BED zinc finger Zn_ribbon_SprT PF17283.2 AIF83418.1 - 0.37 10.7 2.7 3.2 7.8 0.3 2.2 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-H2C2_2 PF13465.6 AIF83418.1 - 0.38 11.3 5.1 8.3 7.0 0.5 2.3 1 1 1 2 2 2 0 Zinc-finger double domain Zn_ribbon_recom PF13408.6 AIF83418.1 - 0.44 11.1 3.5 2.5 8.7 0.3 2.5 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain zinc_ribbon_2 PF13240.6 AIF83418.1 - 0.76 9.6 4.5 8 6.3 0.3 2.2 1 1 2 3 3 3 0 zinc-ribbon domain NAD_kinase PF01513.21 AIF83419.1 - 1.3e-30 106.7 0.8 1.9e-30 106.1 0.6 1.4 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 AIF83419.1 - 0.11 12.1 0.1 0.19 11.3 0.1 1.5 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Rhodanese PF00581.20 AIF83420.1 - 4.8e-39 133.2 0.2 2.8e-19 69.6 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Fer4 PF00037.27 AIF83422.1 - 1.1e-08 34.6 17.9 0.00021 21.0 3.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 AIF83422.1 - 5.5e-06 26.9 8.8 8.2e-06 26.3 7.8 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain ETF_QO PF05187.13 AIF83422.1 - 1.7e-05 24.9 0.5 3.3e-05 24.0 0.5 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_9 PF13187.6 AIF83422.1 - 2.3e-05 24.5 7.6 4.7e-05 23.5 7.6 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIF83422.1 - 0.00027 21.0 8.2 0.00047 20.2 8.2 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIF83422.1 - 0.00029 20.9 9.8 0.00079 19.5 9.7 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Tenui_PVC2 PF06656.11 AIF83422.1 - 0.003 15.5 0.0 0.0055 14.7 0.0 1.3 1 0 0 1 1 1 1 Tenuivirus PVC2 protein Fer4_8 PF13183.6 AIF83422.1 - 0.014 15.8 6.2 0.05 14.1 6.1 1.9 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIF83422.1 - 0.027 14.6 13.3 0.42 10.8 1.9 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain MSP1_C PF07462.11 AIF83422.1 - 0.096 11.4 1.6 0.13 11.0 1.6 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Fer4_3 PF12798.7 AIF83422.1 - 0.11 13.5 15.4 0.97 10.5 5.1 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 AIF83422.1 - 0.11 13.1 5.5 2.2 8.9 0.8 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Sec66 PF09802.9 AIF83422.1 - 0.13 11.8 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 MSA-2c PF12238.8 AIF83422.1 - 0.18 11.8 2.6 0.25 11.3 2.6 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c Fer4_16 PF13484.6 AIF83422.1 - 0.34 11.9 13.8 1.2 10.1 3.0 2.9 2 1 2 4 4 4 0 4Fe-4S double cluster binding domain Fer4_13 PF13370.6 AIF83422.1 - 0.65 10.6 10.6 0.97 10.0 1.0 2.9 3 0 0 3 3 2 0 4Fe-4S single cluster domain of Ferredoxin I DUF1180 PF06679.12 AIF83422.1 - 1.9 8.9 5.3 2.8 8.3 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Fer4_2 PF12797.7 AIF83422.1 - 2.7 8.2 13.8 7.6 6.9 2.2 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 AIF83422.1 - 9.2 6.5 9.3 1.9 8.7 1.4 2.5 1 1 0 2 2 2 0 4Fe-4S dicluster domain Glyco_tranf_2_3 PF13641.6 AIF83423.1 - 4.8e-27 95.3 0.0 1.1e-26 94.2 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 AIF83423.1 - 4.4e-21 75.7 1.2 1.3e-20 74.1 1.2 1.8 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 AIF83423.1 - 5.6e-21 75.1 0.0 1e-20 74.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 AIF83423.1 - 2e-16 60.0 0.1 3.9e-16 59.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Cellulose_synt PF03552.14 AIF83423.1 - 0.0096 14.5 0.6 0.017 13.6 0.0 1.6 2 0 0 2 2 2 1 Cellulose synthase Chordopox_G3 PF06129.12 AIF83423.1 - 0.034 14.9 0.5 0.44 11.3 0.1 2.4 1 1 0 2 2 2 0 Chordopoxvirus G3 protein DUF2207 PF09972.9 AIF83423.1 - 0.78 8.4 2.7 0.74 8.5 1.0 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Herpes_UL35 PF04496.12 AIF83425.1 - 0.069 13.5 0.0 0.08 13.2 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL35 family T3SS_needle_F PF09392.10 AIF83427.1 - 0.049 13.8 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF DUF4350 PF14258.6 AIF83427.1 - 0.12 12.8 0.0 1.9 9.0 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4350) AAA_22 PF13401.6 AIF83428.1 - 0.023 15.0 0.3 0.27 11.5 0.0 2.4 3 0 0 3 3 3 0 AAA domain Cas_Cas1 PF01867.16 AIF83429.1 - 2.9e-48 164.4 0.0 3.8e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 CRISPR associated protein Cas1 SAM_adeno_trans PF01887.16 AIF83429.1 - 0.0063 16.0 0.0 0.0086 15.5 0.0 1.2 1 0 0 1 1 1 1 S-adenosyl-l-methionine hydroxide adenosyltransferase SRP1_TIP1 PF00660.17 AIF83429.1 - 0.066 13.3 0.0 0.16 12.0 0.0 1.7 1 1 0 1 1 1 0 Seripauperin and TIP1 family HEPN PF05168.14 AIF83430.1 - 8.5e-08 32.3 5.8 1.2e-07 31.9 3.6 2.3 2 1 0 2 2 2 1 HEPN domain Pentapeptide PF00805.22 AIF83432.1 - 7.3e-40 134.2 27.3 2e-10 40.1 1.0 6.9 3 3 2 6 6 6 6 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 AIF83432.1 - 4.4e-30 103.7 6.9 2e-10 40.7 1.1 4.6 2 2 2 4 4 4 4 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 AIF83432.1 - 2.5e-19 69.2 2.0 2.4e-07 30.8 2.9 5.6 2 2 1 4 4 4 4 Pentapeptide repeats (9 copies) NACHT PF05729.12 AIF83432.1 - 2.9e-07 30.6 0.1 9.7e-07 28.8 0.1 1.8 1 1 0 1 1 1 1 NACHT domain AAA PF00004.29 AIF83432.1 - 0.064 13.7 0.1 0.2 12.1 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DNA_pol_B_2 PF03175.13 AIF83433.1 - 4.6e-18 65.3 3.6 7.3e-17 61.4 0.2 2.2 2 0 0 2 2 2 2 DNA polymerase type B, organellar and viral Phage_T4_Ndd PF06591.11 AIF83433.1 - 0.025 14.4 0.0 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 T4-like phage nuclear disruption protein (Ndd) SspH PF08141.12 AIF83434.1 - 0.056 13.6 0.0 0.11 12.6 0.0 1.6 1 1 0 1 1 1 0 Small acid-soluble spore protein H family HxlR PF01638.17 AIF83436.1 - 0.0067 16.3 0.6 0.061 13.2 0.0 2.7 1 1 1 2 2 2 1 HxlR-like helix-turn-helix HTH_27 PF13463.6 AIF83436.1 - 0.063 13.8 0.1 0.34 11.4 0.0 2.3 3 0 0 3 3 3 0 Winged helix DNA-binding domain DUF3782 PF12644.7 AIF83436.1 - 0.075 13.2 0.2 3.5 7.9 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3782) MarR_2 PF12802.7 AIF83436.1 - 0.077 12.9 0.1 0.6 10.0 0.1 2.4 2 0 0 2 2 2 0 MarR family Ribosomal_L29 PF00831.23 AIF83436.1 - 1.9 8.5 6.5 1.7 8.7 0.1 3.0 3 0 0 3 3 3 0 Ribosomal L29 protein HicB PF05534.12 AIF83437.1 - 0.011 15.6 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 HicB family CopG_antitoxin PF12441.8 AIF83437.1 - 0.065 13.8 0.0 0.093 13.3 0.0 1.2 1 0 0 1 1 1 0 CopG antitoxin of type II toxin-antitoxin system DUF3237 PF11578.8 AIF83439.1 - 1.9e-06 27.8 2.4 0.00016 21.5 2.4 2.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3237) Alba PF01918.21 AIF83440.1 - 0.18 11.7 0.0 0.58 10.0 0.0 1.8 2 0 0 2 2 2 0 Alba RXLR PF16810.5 AIF83442.1 - 0.0009 19.7 0.0 0.0013 19.1 0.0 1.2 1 0 0 1 1 1 1 RXLR phytopathogen effector protein, Avirulence activity PepSY PF03413.19 AIF83442.1 - 0.0035 17.9 1.0 0.0092 16.5 1.0 1.7 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain fn3_5 PF06280.12 AIF83444.1 - 0.049 14.3 0.1 0.36 11.5 0.0 2.3 2 0 0 2 2 2 0 Fn3-like domain zf-FPG_IleRS PF06827.14 AIF83446.1 - 0.0071 16.2 0.9 0.012 15.4 0.9 1.4 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS DUF496 PF04363.12 AIF83447.1 - 1.6 8.8 5.0 7.4 6.7 0.2 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF496) ALAD PF00490.21 AIF83448.1 - 7.2e-135 449.2 0.1 8.1e-135 449.0 0.1 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase GlutR_N PF05201.15 AIF83449.1 - 1.8e-38 131.6 0.4 4.1e-38 130.4 0.4 1.6 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.20 AIF83449.1 - 5.6e-30 104.2 0.6 3.6e-29 101.6 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.20 AIF83449.1 - 2e-17 63.4 0.3 4.1e-17 62.4 0.3 1.6 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain 2-Hacid_dh_C PF02826.19 AIF83449.1 - 0.002 17.5 0.0 0.0038 16.6 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 AIF83449.1 - 0.035 13.7 0.0 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 AIF83450.1 - 6.5e-20 71.5 0.0 1.4e-19 70.5 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 AIF83450.1 - 1.1e-06 27.9 0.3 1.1e-06 27.9 0.3 2.0 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central Shikimate_DH PF01488.20 AIF83450.1 - 0.001 19.1 0.1 0.0033 17.5 0.0 2.0 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase CysG_dimeriser PF10414.9 AIF83450.1 - 0.0011 18.7 0.3 0.0026 17.5 0.1 1.8 2 0 0 2 2 2 1 Sirohaem synthase dimerisation region TrkA_N PF02254.18 AIF83450.1 - 0.0083 16.4 0.0 0.016 15.5 0.0 1.6 1 1 0 1 1 1 1 TrkA-N domain Pyr_redox PF00070.27 AIF83450.1 - 0.017 15.7 0.6 0.079 13.5 0.1 2.2 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Spt5-NGN PF03439.13 AIF83451.1 - 8.4e-22 76.9 0.0 1.3e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 AIF83451.1 - 7.8e-08 32.0 0.1 1.6e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 KOW motif tRNA_deacylase PF04414.12 AIF83452.1 - 6.9e-63 211.9 0.0 8.2e-63 211.6 0.0 1.1 1 0 0 1 1 1 1 D-aminoacyl-tRNA deacylase SseB_C PF14581.6 AIF83452.1 - 0.17 12.0 0.1 3.6 7.7 0.1 2.2 2 0 0 2 2 2 0 SseB protein C-terminal domain DNA_binding_1 PF01035.20 AIF83453.1 - 1.1e-30 105.6 0.0 1.5e-30 105.1 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Ribosomal_L19e PF01280.20 AIF83454.1 - 3.4e-41 140.7 9.2 3.8e-41 140.5 9.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L19e HTH_12 PF08461.10 AIF83454.1 - 0.0051 16.7 0.3 0.011 15.7 0.3 1.6 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain Ribosomal_L32e PF01655.18 AIF83455.1 - 1.1e-38 132.0 0.2 1.3e-38 131.7 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Metallophos PF00149.28 AIF83457.1 - 2.1e-23 83.9 0.2 2.8e-23 83.5 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AIF83457.1 - 0.0043 17.3 0.1 0.0088 16.2 0.0 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Lactamase_B_2 PF12706.7 AIF83458.1 - 1.3e-22 80.3 0.0 2.2e-11 43.7 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AIF83458.1 - 3.5e-06 27.2 0.0 1.3e-05 25.3 0.0 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 AIF83458.1 - 0.00048 19.8 0.0 0.00099 18.7 0.0 1.5 1 0 0 1 1 1 1 tRNase Z endonuclease NAD_binding_10 PF13460.6 AIF83458.1 - 0.077 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Pribosyltran_N PF13793.6 AIF83459.1 - 1e-27 96.4 0.1 3.9e-26 91.3 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 AIF83459.1 - 2.2e-20 73.5 1.1 3e-19 69.8 1.1 2.3 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 AIF83459.1 - 6.8e-14 51.7 0.6 6.8e-14 51.7 0.6 1.8 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AIF83459.1 - 1.2e-05 24.9 0.1 1.8e-05 24.3 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF3426 PF11906.8 AIF83460.1 - 0.00012 22.2 0.0 0.12 12.6 0.0 2.7 1 1 1 2 2 2 2 Protein of unknown function (DUF3426) DUF2393 PF09624.10 AIF83460.1 - 0.006 16.6 1.7 3.6 7.6 0.1 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF2393) DUF309 PF03745.14 AIF83461.1 - 4e-17 61.6 0.3 7.7e-17 60.7 0.2 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF309) Cu-oxidase_3 PF07732.15 AIF83462.1 - 2.5e-27 95.3 4.5 1.3e-23 83.2 0.4 2.3 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 AIF83462.1 - 3.2e-27 94.9 8.0 1.5e-13 50.6 0.6 3.2 3 0 0 3 3 3 3 Multicopper oxidase Cupredoxin_1 PF13473.6 AIF83462.1 - 0.00021 21.4 0.1 0.047 13.8 0.0 2.6 3 0 0 3 3 3 1 Cupredoxin-like domain Self-incomp_S1 PF05938.11 AIF83462.1 - 0.074 13.6 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 Plant self-incompatibility protein S1 Lipase_C PF18067.1 AIF83462.1 - 0.18 12.4 2.0 1.1 9.9 0.2 2.9 2 1 1 3 3 3 0 Lipase C-terminal domain GAPES2 PF17156.4 AIF83462.1 - 0.19 11.4 0.7 0.31 10.8 0.7 1.3 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain Zip PF02535.22 AIF83463.1 - 9.1e-09 35.0 10.8 9.1e-09 35.0 10.8 2.4 1 1 1 2 2 2 1 ZIP Zinc transporter FixQ PF05545.11 AIF83463.1 - 0.82 9.7 0.0 0.82 9.7 0.0 3.1 4 0 0 4 4 4 0 Cbb3-type cytochrome oxidase component FixQ VAPB_antitox PF02697.14 AIF83464.1 - 0.0049 17.6 0.2 0.042 14.6 0.2 1.9 1 1 0 1 1 1 1 Putative antitoxin DUF2393 PF09624.10 AIF83465.1 - 0.0097 15.9 0.0 0.025 14.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2393) DUF11 PF01345.18 AIF83465.1 - 6.2 7.2 8.4 1.7 9.0 2.2 3.0 3 1 0 3 3 3 0 Domain of unknown function DUF11 zinc_ribbon_4 PF13717.6 AIF83467.1 - 0.21 11.5 1.9 8.9 6.3 0.3 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.6 AIF83467.1 - 0.4 10.5 2.4 11 5.9 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain UPF0547 PF10571.9 AIF83467.1 - 7.6 6.7 7.7 5.5 7.2 0.6 2.7 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 Cu-oxidase_3 PF07732.15 AIF83468.1 - 5.1e-12 45.9 0.4 1.2e-11 44.7 0.4 1.7 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 AIF83468.1 - 6.8e-08 32.3 1.8 0.0037 17.0 0.1 3.2 3 0 0 3 3 3 3 Multicopper oxidase Cupredoxin_1 PF13473.6 AIF83468.1 - 0.0016 18.5 0.0 0.0039 17.3 0.0 1.6 1 0 0 1 1 1 1 Cupredoxin-like domain Pyr_redox_2 PF07992.14 AIF83472.1 - 2e-34 119.1 0.5 3.2e-34 118.5 0.5 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 AIF83472.1 - 2.3e-30 104.7 0.6 3.5e-30 104.1 0.6 1.2 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox PF00070.27 AIF83472.1 - 2.5e-11 44.0 0.7 2.4e-05 24.8 0.0 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AIF83472.1 - 3.4e-08 33.6 0.3 9.6e-07 29.0 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 AIF83472.1 - 9.1e-08 31.7 0.1 0.00052 19.4 0.1 2.4 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 AIF83472.1 - 4.6e-06 26.1 0.5 4.8e-05 22.7 0.1 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 AIF83472.1 - 5.7e-06 25.8 0.0 0.064 12.5 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AIF83472.1 - 2.2e-05 23.4 0.4 0.00028 19.7 0.2 2.2 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 AIF83472.1 - 9e-05 22.2 4.0 0.16 11.5 0.7 3.6 3 1 1 4 4 4 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 AIF83472.1 - 0.00084 18.7 0.4 0.09 12.0 0.0 2.3 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 AIF83472.1 - 0.0055 15.8 1.2 0.12 11.4 0.3 2.6 3 0 0 3 3 3 1 FAD binding domain NAD_binding_7 PF13241.6 AIF83472.1 - 0.0055 17.1 0.1 0.75 10.3 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 AIF83472.1 - 0.0085 15.4 0.1 0.49 9.7 0.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 AIF83472.1 - 0.011 15.8 0.3 0.069 13.1 0.0 2.4 3 0 0 3 3 3 0 FAD-NAD(P)-binding Fer4_7 PF12838.7 AIF83472.1 - 0.014 15.9 2.0 0.06 14.0 0.4 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIF83472.1 - 0.028 14.9 3.8 0.083 13.4 3.8 1.9 1 1 0 1 1 1 0 4Fe-4S dicluster domain 2-Hacid_dh_C PF02826.19 AIF83472.1 - 0.036 13.4 0.0 0.1 11.9 0.0 1.7 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Fer4_2 PF12797.7 AIF83472.1 - 0.039 14.0 2.4 0.039 14.0 2.4 2.2 2 0 0 2 2 1 0 4Fe-4S binding domain Fer4_4 PF12800.7 AIF83472.1 - 0.048 14.2 0.7 0.048 14.2 0.7 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Lycopene_cycl PF05834.12 AIF83472.1 - 0.071 12.1 0.1 0.46 9.5 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Fer4_18 PF13746.6 AIF83472.1 - 0.077 13.2 0.2 0.41 10.8 0.1 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain GIDA PF01134.22 AIF83472.1 - 0.12 11.5 0.1 0.93 8.5 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A Fer4_10 PF13237.6 AIF83472.1 - 0.33 11.1 5.3 0.73 10.0 5.3 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIF83472.1 - 9.5 6.5 8.6 0.49 10.5 2.0 2.1 2 0 0 2 2 2 0 4Fe-4S binding domain PKD PF00801.20 AIF83473.1 - 4.7e-13 48.8 0.7 8.3e-13 48.0 0.7 1.4 1 0 0 1 1 1 1 PKD domain DUF5011 PF16403.5 AIF83473.1 - 0.0093 16.1 1.9 0.016 15.3 1.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5011) ChitinaseA_N PF08329.10 AIF83473.1 - 0.093 12.4 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Chitinase A, N-terminal domain Herpes_UL74 PF07982.12 AIF83473.1 - 0.19 10.7 1.6 0.27 10.2 1.6 1.1 1 0 0 1 1 1 0 Herpes UL74 glycoproteins GTP_EFTU_D2 PF03144.25 AIF83474.1 - 3.7e-07 30.4 0.1 8.5e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 AIF83474.1 - 0.08 12.9 0.2 0.2 11.6 0.2 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 4 DUF99 PF01949.16 AIF83475.1 - 3.4e-59 199.3 0.1 3.8e-59 199.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF99 zf-C2H2 PF00096.26 AIF83476.1 - 1e-05 25.7 0.1 2.1e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF83476.1 - 6.6e-05 23.4 0.1 0.00028 21.5 0.1 2.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AIF83476.1 - 0.00016 21.9 0.4 0.00029 21.0 0.4 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AIF83476.1 - 0.0013 18.7 0.1 0.0021 18.0 0.1 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger DUF2171 PF09939.9 AIF83476.1 - 0.0024 18.1 1.5 0.0034 17.6 1.5 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2171) zf-met PF12874.7 AIF83476.1 - 0.0049 17.2 0.1 0.0084 16.5 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf_UBZ PF18439.1 AIF83476.1 - 0.044 13.4 0.2 0.066 12.8 0.2 1.3 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-H2C2_2 PF13465.6 AIF83476.1 - 0.21 12.1 1.9 0.55 10.8 1.0 2.2 2 0 0 2 2 2 0 Zinc-finger double domain Zn-C2H2_12 PF18112.1 AIF83476.1 - 0.25 11.8 0.3 0.25 11.8 0.3 2.0 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Fe-ADH_2 PF13685.6 AIF83477.1 - 2.2e-62 211.0 0.1 3.1e-62 210.5 0.1 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 AIF83477.1 - 6.1e-23 81.2 0.6 1.1e-21 77.0 0.6 2.0 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 AIF83477.1 - 1.2e-06 27.9 0.3 3.2e-05 23.2 0.3 2.7 1 1 0 1 1 1 1 3-dehydroquinate synthase AIRC PF00731.20 AIF83477.1 - 0.026 14.1 0.3 0.075 12.6 0.0 1.9 2 0 0 2 2 2 0 AIR carboxylase TRAM PF01938.20 AIF83478.1 - 4.4e-12 45.8 0.3 6.2e-12 45.3 0.3 1.2 1 0 0 1 1 1 1 TRAM domain KH_7 PF17214.3 AIF83479.1 - 5.2e-22 77.6 0.1 8.3e-20 70.5 0.2 2.9 2 0 0 2 2 2 1 KH domain Beta-Casp PF10996.8 AIF83479.1 - 2.6e-19 69.5 0.0 6.6e-18 65.0 0.0 2.7 3 0 0 3 3 3 1 Beta-Casp domain Lactamase_B PF00753.27 AIF83479.1 - 2.6e-13 50.5 0.1 7.7e-13 48.9 0.1 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 AIF83479.1 - 1.1e-12 47.7 0.0 2.7e-12 46.4 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 AIF83479.1 - 1.1e-11 44.5 0.0 2.3e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 AIF83479.1 - 1e-09 38.2 0.0 1.7e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AIF83479.1 - 0.0026 17.7 0.0 0.007 16.3 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain SepF PF04472.12 AIF83480.1 - 9.3e-14 51.5 0.1 1.1e-13 51.3 0.1 1.1 1 0 0 1 1 1 1 Cell division protein SepF NFACT-R_2 PF18297.1 AIF83481.1 - 7.4e-23 80.7 0.0 1.5e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 NFACT protein RNA binding domain tRNA_Me_trans PF03054.16 AIF83481.1 - 1.8e-14 53.3 0.0 2.8e-13 49.4 0.0 2.2 1 1 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 AIF83481.1 - 2.5e-14 53.3 0.0 4e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) NFACT-R_1 PF05670.13 AIF83481.1 - 1.1e-05 26.0 0.0 6.5e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 NFACT protein RNA binding domain QueC PF06508.13 AIF83481.1 - 0.002 17.6 0.0 0.0041 16.7 0.0 1.6 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 AIF83481.1 - 0.0022 17.7 0.0 0.0034 17.1 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase HTH_8 PF02954.19 AIF83481.1 - 0.047 13.5 0.0 4.8 7.1 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family HTH_23 PF13384.6 AIF83481.1 - 0.067 13.0 0.0 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain NAD_synthase PF02540.17 AIF83481.1 - 0.11 11.6 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 NAD synthase tRNA_synthFbeta PF17759.1 AIF83482.1 - 1.3e-41 142.4 0.0 6.7e-41 140.1 0.0 1.9 2 0 0 2 2 2 1 Phenylalanyl tRNA synthetase beta chain CLM domain B5 PF03484.15 AIF83482.1 - 3.4e-18 65.7 0.0 4e-16 59.1 0.0 2.8 3 0 0 3 3 3 1 tRNA synthetase B5 domain B3_4 PF03483.17 AIF83482.1 - 4.6e-13 49.2 0.0 7.9e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain RolB_RolC PF02027.17 AIF83482.1 - 0.057 13.1 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 RolB/RolC glucosidase family tRNA-synt_2d PF01409.20 AIF83483.1 - 1e-83 280.6 0.0 1.3e-83 280.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA_synthFbeta PF17759.1 AIF83483.1 - 3.3e-07 30.0 0.0 1.3e-05 24.8 0.0 3.0 1 1 1 2 2 2 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 AIF83483.1 - 0.001 18.2 0.2 0.024 13.7 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) HTH_20 PF12840.7 AIF83483.1 - 0.0074 16.3 0.1 0.025 14.6 0.1 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain PheRS_DBD3 PF18553.1 AIF83483.1 - 0.01 16.1 0.1 0.05 13.9 0.0 2.2 2 0 0 2 2 2 0 PheRS DNA binding domain 3 tRNA-synt_2b PF00587.25 AIF83483.1 - 0.012 15.6 0.0 0.024 14.6 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_His PF13393.6 AIF83483.1 - 0.095 11.9 0.2 0.93 8.7 0.0 2.2 2 0 0 2 2 2 0 Histidyl-tRNA synthetase CFIA_Pcf11 PF11526.8 AIF83483.1 - 0.19 12.2 0.4 0.44 11.0 0.2 1.6 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 DprA_WH PF17782.1 AIF83483.1 - 0.63 10.2 7.0 0.8 9.9 0.2 3.1 3 0 0 3 3 3 0 DprA winged helix domain tRNA-synt_1b PF00579.25 AIF83484.1 - 1.4e-21 77.1 0.0 2.5e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.18 AIF83484.1 - 0.034 13.1 0.0 0.091 11.7 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (K) CTP_transf_like PF01467.26 AIF83487.1 - 8.8e-17 61.6 0.0 1.1e-16 61.3 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 AIF83487.1 - 0.0066 16.4 0.2 0.016 15.1 0.2 1.7 2 0 0 2 2 2 1 FAD synthetase DUF2833 PF11090.8 AIF83487.1 - 0.062 13.7 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2833) Pantoate_ligase PF02569.15 AIF83487.1 - 0.12 11.6 0.0 0.43 9.7 0.0 1.8 2 0 0 2 2 2 0 Pantoate-beta-alanine ligase Fer4 PF00037.27 AIF83488.1 - 1.1e-07 31.4 23.4 0.00012 21.7 3.3 2.7 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_7 PF12838.7 AIF83488.1 - 3.8e-06 27.4 7.7 3.8e-06 27.4 7.7 2.3 2 1 1 3 3 3 2 4Fe-4S dicluster domain ETF_QO PF05187.13 AIF83488.1 - 2.1e-05 24.6 0.6 2.1e-05 24.6 0.6 1.6 2 0 0 2 2 2 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_9 PF13187.6 AIF83488.1 - 2.3e-05 24.5 7.6 2.3e-05 24.5 7.6 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIF83488.1 - 0.00023 21.2 8.2 0.00023 21.2 8.2 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIF83488.1 - 0.00052 20.1 10.1 0.00052 20.1 10.1 2.1 2 1 1 3 3 2 2 4Fe-4S dicluster domain Tenui_PVC2 PF06656.11 AIF83488.1 - 0.0019 16.2 0.0 0.0024 15.9 0.0 1.1 1 0 0 1 1 1 1 Tenuivirus PVC2 protein zinc_ribbon_11 PF11682.8 AIF83488.1 - 0.035 14.1 0.1 0.035 14.1 0.1 1.6 2 0 0 2 2 2 0 Probable zinc-ribbon Fer4_8 PF13183.6 AIF83488.1 - 0.037 14.5 6.6 0.037 14.5 6.6 2.2 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIF83488.1 - 0.065 14.2 17.1 0.59 11.2 5.1 3.0 3 1 0 3 3 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 AIF83488.1 - 0.2 12.2 9.1 1.3 9.7 0.8 3.0 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIF83488.1 - 0.29 12.1 15.0 0.69 10.9 3.0 2.9 2 1 1 3 3 2 0 4Fe-4S double cluster binding domain DEC-1_N PF04625.13 AIF83488.1 - 0.38 9.7 7.2 0.46 9.4 7.2 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Fer4_13 PF13370.6 AIF83488.1 - 1.5 9.4 13.2 0.57 10.8 1.0 2.9 3 0 0 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_6 PF12837.7 AIF83488.1 - 2.6 8.3 22.5 0.25 11.5 1.9 3.1 4 0 0 4 4 3 0 4Fe-4S binding domain Fer4_18 PF13746.6 AIF83488.1 - 4.4 7.5 9.9 0.84 9.8 1.4 2.5 1 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIF83488.1 - 7.4 6.9 18.4 4.6 7.6 2.2 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain MSA-2c PF12238.8 AIF83488.1 - 9.3 6.2 8.4 12 5.8 8.4 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c TPP_enzyme_N PF02776.18 AIF83489.1 - 1.2e-49 168.2 0.2 1.1e-48 165.1 0.1 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 AIF83489.1 - 3.6e-42 143.7 0.3 2e-41 141.4 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 AIF83489.1 - 1.4e-31 109.0 0.0 3.1e-31 107.9 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 AIF83489.1 - 8.7e-05 22.4 0.2 0.00018 21.3 0.2 1.5 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg VIT1 PF01988.19 AIF83490.1 - 9.3e-52 176.0 3.8 1.1e-51 175.8 3.8 1.0 1 0 0 1 1 1 1 VIT family DUF4781 PF16013.5 AIF83490.1 - 0.052 12.3 0.9 0.52 9.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) FNIP_M PF14637.6 AIF83490.1 - 0.23 11.4 0.1 0.33 10.9 0.1 1.2 1 0 0 1 1 1 0 Folliculin-interacting protein middle domain Peptidase_U4 PF03419.13 AIF83490.1 - 0.66 9.2 4.0 0.44 9.8 1.4 1.8 2 0 0 2 2 2 0 Sporulation factor SpoIIGA LapA_dom PF06305.11 AIF83490.1 - 0.81 9.5 8.7 1.1 9.1 0.1 3.3 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain TrmB PF01978.19 AIF83491.1 - 8.3e-17 60.8 0.2 7.9e-16 57.7 0.1 2.3 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 AIF83491.1 - 8.6e-10 38.2 0.6 0.00016 21.0 0.1 2.2 2 0 0 2 2 2 2 Archaeal transcriptional regulator TrmB PLDc_2 PF13091.6 AIF83491.1 - 1.3e-06 28.4 0.2 0.018 14.9 0.0 2.9 2 1 0 2 2 2 2 PLD-like domain HTH_5 PF01022.20 AIF83491.1 - 0.00079 19.2 0.1 0.0062 16.4 0.0 2.3 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 AIF83491.1 - 0.0018 18.1 0.2 0.008 16.0 0.2 2.2 1 0 0 1 1 1 1 MarR family MarR PF01047.22 AIF83491.1 - 0.0044 16.9 0.2 0.016 15.1 0.2 2.0 1 0 0 1 1 1 1 MarR family HTH_IclR PF09339.10 AIF83491.1 - 0.0053 16.5 0.8 0.035 13.9 0.4 2.5 2 0 0 2 2 2 1 IclR helix-turn-helix domain HTH_Crp_2 PF13545.6 AIF83491.1 - 0.013 15.5 0.1 0.038 14.0 0.1 1.8 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Hydrolase PF00702.26 AIF83491.1 - 0.015 15.6 0.2 0.19 12.0 0.2 2.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Rrf2 PF02082.20 AIF83491.1 - 0.025 14.9 0.2 0.088 13.2 0.2 1.9 1 0 0 1 1 1 0 Transcriptional regulator PadR PF03551.14 AIF83491.1 - 0.025 14.5 0.0 0.085 12.8 0.0 1.9 1 1 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_27 PF13463.6 AIF83491.1 - 0.063 13.8 0.4 0.81 10.2 0.1 2.7 3 0 0 3 3 2 0 Winged helix DNA-binding domain HTH_24 PF13412.6 AIF83491.1 - 0.079 12.5 0.4 0.25 10.9 0.2 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding EccE PF11203.8 AIF83491.1 - 0.14 12.5 1.4 16 5.9 0.1 3.1 3 0 0 3 3 3 0 Putative type VII ESX secretion system translocon, EccE Peptidase_M10 PF00413.24 AIF83492.1 - 6.4e-13 48.8 0.0 9.6e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 AIF83492.1 - 6.1e-05 23.5 0.0 8.8e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 AIF83492.1 - 8.8e-05 21.9 0.1 0.00014 21.2 0.1 1.3 1 0 0 1 1 1 1 Met-zincin Peptidase_M57 PF12388.8 AIF83492.1 - 0.00077 19.1 0.0 0.001 18.7 0.0 1.3 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Reprolysin_4 PF13583.6 AIF83492.1 - 0.0012 18.6 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 AIF83492.1 - 0.0015 18.7 0.1 0.0022 18.2 0.1 1.3 1 1 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M54 PF07998.11 AIF83492.1 - 0.0048 16.9 0.0 0.0068 16.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M54 Peptidase_M66 PF10462.9 AIF83492.1 - 0.015 14.2 0.0 0.023 13.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase M66 DUF45 PF01863.17 AIF83492.1 - 0.021 14.8 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 Reprolysin_2 PF13574.6 AIF83492.1 - 0.044 13.7 0.0 0.071 13.0 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 AIF83492.1 - 0.12 12.0 0.1 0.18 11.4 0.1 1.2 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Metallopep PF12044.8 AIF83492.1 - 0.19 10.3 0.1 0.32 9.5 0.1 1.3 1 0 0 1 1 1 0 Putative peptidase family SKA2 PF16740.5 AIF83493.1 - 0.13 12.1 0.0 0.13 12.1 0.0 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF16 PF01519.16 AIF83493.1 - 1.2 9.6 9.7 2.7 8.5 6.1 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 CCDC84 PF14968.6 AIF83493.1 - 5 6.7 12.3 1.8 8.1 9.6 1.6 2 0 0 2 2 2 0 Coiled coil protein 84 DUF4106 PF13388.6 AIF83493.1 - 6 6.0 22.9 9 5.4 22.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) V4R PF02830.18 AIF83494.1 - 2e-11 43.8 0.1 3.6e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 V4R domain HTH_CodY PF08222.11 AIF83494.1 - 0.003 17.1 0.1 0.0089 15.6 0.1 1.8 1 0 0 1 1 1 1 CodY helix-turn-helix domain HTH_24 PF13412.6 AIF83494.1 - 0.0031 17.0 0.0 0.0057 16.2 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.6 AIF83494.1 - 0.015 15.2 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Rrf2 PF02082.20 AIF83494.1 - 0.037 14.4 0.0 0.065 13.6 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator HTH_5 PF01022.20 AIF83494.1 - 0.067 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Big_3 PF07523.12 AIF83497.1 - 0.044 14.1 0.9 0.11 12.8 0.3 2.0 2 1 0 2 2 2 0 Bacterial Ig-like domain (group 3) GW PF13457.6 AIF83498.1 - 0.088 13.4 0.3 7.2 7.3 0.1 2.2 2 0 0 2 2 2 0 GW (Gly-Tryp) dipeptide domain HemolysinCabind PF00353.19 AIF83499.1 - 7.5e-37 124.9 119.3 3.6e-09 36.4 15.0 7.9 3 2 4 8 8 8 8 RTX calcium-binding nonapeptide repeat (4 copies) PKD PF00801.20 AIF83499.1 - 4.9e-17 61.5 63.5 3.6e-05 23.5 1.5 8.6 8 0 0 8 8 8 6 PKD domain Y_Y_Y PF07495.13 AIF83499.1 - 0.00042 20.2 1.7 1.2 9.2 0.0 4.3 4 0 0 4 4 4 2 Y_Y_Y domain SLT_2 PF13406.6 AIF83499.1 - 0.21 10.8 1.8 1.5 8.0 0.1 3.1 4 0 0 4 4 4 0 Transglycosylase SLT domain HemolysinCabind PF00353.19 AIF83500.1 - 7.1e-23 80.2 54.5 4.8e-11 42.4 10.1 4.3 4 0 0 4 4 4 3 RTX calcium-binding nonapeptide repeat (4 copies) PKD PF00801.20 AIF83500.1 - 3.3e-16 58.9 27.2 4.7e-07 29.6 5.2 4.7 4 0 0 4 4 4 4 PKD domain VCBS PF13517.6 AIF83500.1 - 7.5e-05 23.2 10.6 0.81 10.3 0.2 5.6 5 0 0 5 5 5 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Big_7 PF17957.1 AIF83500.1 - 0.064 14.0 24.0 0.54 11.1 0.6 4.9 4 1 0 4 4 4 0 Bacterial Ig domain Dockerin_1 PF00404.18 AIF83500.1 - 6.5 7.0 6.4 68 3.8 0.1 4.0 4 0 0 4 4 4 0 Dockerin type I domain DUF11 PF01345.18 AIF83502.1 - 0.0017 18.6 0.1 0.0077 16.5 0.0 2.1 2 1 0 2 2 2 1 Domain of unknown function DUF11 HATPase_c PF02518.26 AIF83503.1 - 2.2e-25 89.4 0.1 4.8e-25 88.2 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 AIF83503.1 - 1.5e-19 70.7 0.0 3.2e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 Cache domain HisKA PF00512.25 AIF83503.1 - 3.6e-12 46.1 0.4 1.1e-11 44.6 0.4 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 AIF83503.1 - 0.00085 19.2 0.2 0.0026 17.6 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 AIF83503.1 - 0.0016 18.3 0.1 0.0057 16.5 0.0 2.0 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.6 AIF83503.1 - 0.0032 17.4 0.0 0.0072 16.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain NitrOD5 PF11537.8 AIF83504.1 - 0.00015 21.8 0.1 0.00018 21.5 0.1 1.2 1 0 0 1 1 1 1 Nitrosopumilus output domain 5 CsgA PF17334.2 AIF83504.1 - 0.078 13.7 0.3 0.21 12.3 0.2 1.7 1 1 1 2 2 2 0 Minor curli fiber component A TackOD1 PF18551.1 AIF83505.1 - 5e-29 101.3 1.1 6.6e-29 100.9 1.1 1.1 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 Zn-ribbon_8 PF09723.10 AIF83505.1 - 0.0016 18.5 16.8 0.057 13.5 0.9 4.4 3 1 1 4 4 4 2 Zinc ribbon domain zf-P11 PF03854.14 AIF83505.1 - 0.021 14.5 1.6 0.26 11.0 1.4 2.4 2 0 0 2 2 2 0 P-11 zinc finger C1_1 PF00130.22 AIF83505.1 - 0.04 13.8 5.0 0.18 11.7 0.8 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc-ribbons_6 PF07191.12 AIF83505.1 - 0.065 13.2 9.3 1.4 9.0 1.3 2.9 1 1 2 3 3 3 0 zinc-ribbons Ribosomal_L37ae PF01780.19 AIF83505.1 - 0.098 12.8 2.6 0.5 10.5 1.2 2.3 1 1 1 2 2 2 0 Ribosomal L37ae protein family DUF35_N PF12172.8 AIF83505.1 - 0.13 12.2 10.8 0.99 9.4 0.4 3.2 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF3797 PF12677.7 AIF83505.1 - 0.16 11.9 1.6 6.9 6.6 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3797) zf_UBZ PF18439.1 AIF83505.1 - 0.21 11.2 9.5 2.3 7.9 0.3 4.2 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger DZR PF12773.7 AIF83505.1 - 0.24 11.4 8.0 3 8.0 8.1 2.4 1 1 0 1 1 1 0 Double zinc ribbon zf-C2H2 PF00096.26 AIF83505.1 - 0.32 11.6 10.7 2.7 8.6 1.3 3.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type HypA PF01155.19 AIF83505.1 - 0.38 10.8 8.6 10 6.2 0.4 3.2 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TF_Zn_Ribbon PF08271.12 AIF83505.1 - 0.5 9.9 9.7 3.1 7.4 2.1 4.0 3 1 0 3 3 3 0 TFIIB zinc-binding CpXC PF14353.6 AIF83505.1 - 0.94 9.5 6.0 1.1 9.4 0.9 3.2 4 0 0 4 4 4 0 CpXC protein A2L_zn_ribbon PF08792.10 AIF83505.1 - 0.96 9.2 9.2 0.61 9.9 0.2 3.7 4 0 0 4 4 4 0 A2L zinc ribbon domain zf-ribbon_3 PF13248.6 AIF83505.1 - 1.2 8.7 9.6 0.65 9.5 0.9 3.3 3 0 0 3 3 3 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIF83505.1 - 1.9 8.5 9.1 0.1 12.5 1.5 2.5 3 0 0 3 3 3 0 Putative transposase DNA-binding domain Rep_fac-A_C PF08646.10 AIF83505.1 - 9.3 6.0 6.0 1.3 8.8 0.6 2.1 1 1 0 2 2 2 0 Replication factor-A C terminal domain zf-AN1 PF01428.16 AIF83505.1 - 9.6 6.5 11.8 31 4.8 3.4 3.1 2 1 1 3 3 3 0 AN1-like Zinc finger Glyco_tranf_2_3 PF13641.6 AIF83506.1 - 3.7e-28 99.0 0.0 4.9e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 AIF83506.1 - 2.8e-24 86.1 1.9 2.8e-24 86.1 1.9 1.6 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 AIF83506.1 - 1.3e-14 54.4 0.0 1.8e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 AIF83506.1 - 1.9e-08 34.0 0.1 3.1e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Cellulose_synt PF03552.14 AIF83506.1 - 0.03 12.9 1.0 0.85 8.0 0.3 2.5 2 1 1 3 3 3 0 Cellulose synthase Response_reg PF00072.24 AIF83507.1 - 2.9e-24 85.4 0.8 2e-23 82.7 0.1 2.3 3 0 0 3 3 3 1 Response regulator receiver domain UPF0180 PF03698.13 AIF83507.1 - 0.00028 21.0 0.3 0.01 16.0 0.2 3.0 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0180) Thy1 PF02511.15 AIF83508.1 - 1.2e-34 119.8 0.0 1.3e-18 67.5 1.5 2.5 2 1 0 2 2 2 2 Thymidylate synthase complementing protein rpo132 PF12415.8 AIF83508.1 - 0.17 11.2 0.2 16 4.9 0.1 2.4 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase DivIVA PF05103.13 AIF83509.1 - 0.02 15.0 2.3 0.041 14.0 2.1 1.6 1 1 1 2 2 2 0 DivIVA protein ApoLp-III PF07464.11 AIF83509.1 - 0.14 12.3 9.8 0.29 11.2 7.6 2.3 1 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) CdvA PF18822.1 AIF83510.1 - 1.2e-30 105.8 9.9 1.9e-30 105.2 9.9 1.3 1 0 0 1 1 1 1 CdvA-like coiled-coil domain PRC PF05239.16 AIF83510.1 - 0.011 15.8 1.1 0.03 14.4 1.1 1.7 1 0 0 1 1 1 0 PRC-barrel domain DUF3275 PF11679.8 AIF83510.1 - 0.099 12.6 4.3 0.12 12.3 3.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3275) Mucin PF01456.17 AIF83510.1 - 2.5 8.1 16.3 3.8 7.5 16.3 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein COX1 PF00115.20 AIF83511.1 - 4e-129 431.2 61.4 4.9e-129 430.9 61.4 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DHHC PF01529.20 AIF83512.1 - 2.9 8.0 7.6 0.98 9.5 2.6 2.1 1 1 1 2 2 2 0 DHHC palmitoyltransferase FixP_N PF14715.6 AIF83512.1 - 3.8 7.3 0.0 3.8 7.3 0.0 3.6 4 0 0 4 4 4 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Flavin_Reduct PF01613.18 AIF83513.1 - 9.5e-27 93.9 0.0 1.6e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Flavin reductase like domain DUF447 PF04289.12 AIF83513.1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF447) Aminotran_3 PF00202.21 AIF83514.1 - 1.4e-57 195.2 0.0 2e-57 194.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 AIF83514.1 - 0.00045 19.5 0.0 0.0032 16.7 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class I and II FAM221 PF14753.6 AIF83515.1 - 0.021 14.4 1.4 0.025 14.2 1.4 1.1 1 0 0 1 1 1 0 Protein FAM221A/B KfrB PF18790.1 AIF83516.1 - 0.047 13.9 0.0 0.071 13.4 0.0 1.2 1 0 0 1 1 1 0 KfrB protein DUF2678 PF10856.8 AIF83516.1 - 0.15 12.0 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2678) ResIII PF04851.15 AIF83518.1 - 2.7e-16 60.0 0.0 6.8e-16 58.7 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AIF83518.1 - 6.5e-13 49.0 0.0 4.7e-12 46.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 AIF83518.1 - 3.6e-10 39.9 0.1 1.6e-09 37.8 0.0 2.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 AIF83518.1 - 5.5e-06 25.8 0.1 1.1e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.6 AIF83518.1 - 0.00033 20.5 0.0 0.067 12.9 0.1 2.7 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 AIF83518.1 - 0.0068 16.7 0.8 0.99 9.7 0.0 3.0 2 1 0 2 2 2 1 AAA domain Ribo_biogen_C PF04034.13 AIF83519.1 - 3.8e-40 136.6 0.0 4.6e-40 136.3 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 AIF83519.1 - 0.0013 18.5 0.1 0.0021 17.9 0.1 1.3 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Phage_TAC_8 PF10666.9 AIF83519.1 - 0.042 14.1 0.0 0.064 13.5 0.0 1.3 1 0 0 1 1 1 0 Phage tail assembly chaperone protein Gp14 ()A118 DUF3574 PF12098.8 AIF83520.1 - 5.1e-05 23.0 0.0 5.4e-05 22.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3574) Methyltr_RsmB-F PF01189.17 AIF83523.1 - 2.5e-57 193.7 0.0 3.8e-57 193.2 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 AIF83523.1 - 5.3e-11 42.9 0.0 1.2e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 AIF83523.1 - 0.0012 19.0 0.1 0.0019 18.3 0.1 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase POR PF01558.18 AIF83523.1 - 0.0045 17.1 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase Methyltransf_31 PF13847.6 AIF83523.1 - 0.01 15.7 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 AIF83523.1 - 0.025 14.3 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 AIF83523.1 - 0.11 13.2 0.1 0.35 11.6 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain UPF0113 PF03657.13 AIF83524.1 - 1.2e-22 79.9 0.1 2.1e-22 79.2 0.1 1.4 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 AIF83524.1 - 3e-09 36.7 0.1 6.6e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 PUA domain UPF0113_N PF17833.1 AIF83524.1 - 2.8e-08 34.2 0.0 6.2e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain eRF1_2 PF03464.15 AIF83524.1 - 0.096 13.0 0.1 1.4 9.3 0.1 2.4 1 1 0 1 1 1 0 eRF1 domain 2 HTH_7 PF02796.15 AIF83525.1 - 0.00077 19.5 0.0 0.0015 18.6 0.0 1.4 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase DUF433 PF04255.14 AIF83525.1 - 0.041 13.8 0.1 0.056 13.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF433) HTH_38 PF13936.6 AIF83525.1 - 0.045 13.5 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2316 PF10078.9 AIF83525.1 - 0.047 13.9 0.0 0.049 13.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) HTH_39 PF14090.6 AIF83525.1 - 0.098 12.4 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain Recombinase PF07508.13 AIF83525.1 - 0.14 12.6 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Recombinase HTH_28 PF13518.6 AIF83525.1 - 0.21 11.7 0.0 0.27 11.4 0.0 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4719 PF15843.5 AIF83526.1 - 0.21 11.7 0.5 0.35 10.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4719) UPF0052 PF01933.18 AIF83527.1 - 8.9e-48 163.0 0.1 1.1e-47 162.8 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 CofC PF01983.16 AIF83528.1 - 2.7e-27 95.4 0.1 3.6e-27 95.0 0.1 1.0 1 0 0 1 1 1 1 Guanylyl transferase CofC like NTP_transf_3 PF12804.7 AIF83528.1 - 1.1e-06 29.2 0.9 1.4e-06 28.7 0.8 1.3 1 1 0 1 1 1 1 MobA-like NTP transferase domain ADH_zinc_N PF00107.26 AIF83528.1 - 0.0092 16.0 0.1 0.017 15.1 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DnaGprimase_HBD PF16730.5 AIF83528.1 - 0.063 13.4 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain Mrr_cat PF04471.12 AIF83530.1 - 0.00013 22.0 0.0 0.00021 21.3 0.0 1.4 1 0 0 1 1 1 1 Restriction endonuclease NERD PF08378.11 AIF83530.1 - 0.0034 17.8 0.0 0.005 17.3 0.0 1.3 1 0 0 1 1 1 1 Nuclease-related domain DprA_WH PF17782.1 AIF83530.1 - 0.047 13.8 0.8 0.75 10.0 0.1 2.5 2 0 0 2 2 2 0 DprA winged helix domain MTES_1575 PF18741.1 AIF83530.1 - 0.16 12.1 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 REase_MTES_1575 S4 PF01479.25 AIF83530.1 - 0.18 11.6 0.0 0.39 10.5 0.0 1.6 1 0 0 1 1 1 0 S4 domain DUF2070 PF09843.9 AIF83531.1 - 7.5e-119 397.6 0.1 9e-119 397.3 0.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) Sec61_beta PF03911.16 AIF83532.1 - 1.9e-14 53.4 0.7 2.1e-14 53.2 0.7 1.1 1 0 0 1 1 1 1 Sec61beta family Auto_anti-p27 PF06677.12 AIF83533.1 - 3.1e-08 33.6 0.6 4.4e-08 33.1 0.6 1.3 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) TraF PF13728.6 AIF83533.1 - 0.04 13.7 0.1 0.048 13.5 0.1 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein TackOD1 PF18551.1 AIF83533.1 - 0.049 13.3 0.2 0.077 12.7 0.2 1.3 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 OrfB_Zn_ribbon PF07282.11 AIF83533.1 - 0.23 11.4 1.2 0.42 10.6 1.2 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-IS66 PF13005.7 AIF83533.1 - 0.34 11.3 5.8 5.2 7.5 0.3 2.8 2 1 1 3 3 3 0 zinc-finger binding domain of transposase IS66 zinc_ribbon_2 PF13240.6 AIF83533.1 - 0.44 10.3 4.6 10 6.0 0.8 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-RRN7 PF11781.8 AIF83533.1 - 0.63 9.8 3.1 1.7 8.4 3.1 1.7 1 1 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Lar_restr_allev PF14354.6 AIF83533.1 - 1.3 9.4 4.5 6.4 7.2 4.5 2.1 1 1 0 1 1 1 0 Restriction alleviation protein Lar SUI1 PF01253.22 AIF83534.1 - 3.2e-20 72.4 0.0 4.8e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.14 AIF83534.1 - 0.0025 18.1 0.0 0.0031 17.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) DTW PF03942.15 AIF83534.1 - 0.044 13.5 0.1 0.046 13.4 0.1 1.1 1 0 0 1 1 1 0 DTW domain Paramyxo_C PF01692.18 AIF83534.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C CHASE PF03924.13 AIF83535.1 - 9e-58 195.3 0.5 1.5e-57 194.6 0.5 1.4 1 0 0 1 1 1 1 CHASE domain HATPase_c PF02518.26 AIF83535.1 - 2.1e-28 99.1 0.1 7.2e-28 97.3 0.1 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIF83535.1 - 3.9e-12 46.0 0.1 1.6e-11 44.1 0.0 2.1 1 1 1 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 AIF83535.1 - 5e-06 26.4 0.1 1.8e-05 24.6 0.1 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 AIF83535.1 - 0.0028 18.0 0.2 0.0097 16.3 0.2 2.0 1 0 0 1 1 1 1 HAMP domain Bul1_C PF04426.12 AIF83535.1 - 0.0062 16.0 0.1 0.23 10.9 0.0 2.3 1 1 1 2 2 2 1 Bul1 C terminus MWFE PF15879.5 AIF83535.1 - 0.0095 16.1 0.1 1.5 9.0 0.1 2.6 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase MWFE subunit Phage_holin_5_2 PF16079.5 AIF83535.1 - 0.021 15.2 0.1 0.44 10.9 0.0 2.3 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V DUF4179 PF13786.6 AIF83535.1 - 0.048 14.1 0.8 18 5.8 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) DUF3574 PF12098.8 AIF83535.1 - 0.11 12.3 0.0 1.1 9.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3574) DPM2 PF07297.12 AIF83535.1 - 0.23 11.8 3.2 2.1 8.7 0.5 2.4 2 0 0 2 2 2 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) TFIIB PF00382.19 AIF83537.1 - 6.4e-36 122.2 6.8 1.9e-18 66.2 1.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIF83537.1 - 1.7e-11 43.4 1.4 3.2e-11 42.6 1.4 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 AIF83537.1 - 0.00017 21.6 0.2 0.2 11.7 0.0 2.3 1 1 0 2 2 2 2 Cyclin, C-terminal domain Sigma70_r4 PF04545.16 AIF83537.1 - 0.00046 19.7 0.0 0.03 13.9 0.0 2.7 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_36 PF13730.6 AIF83537.1 - 0.00089 19.2 1.8 4.1 7.4 0.1 3.3 3 0 0 3 3 3 2 Helix-turn-helix domain Cyclin_N PF00134.23 AIF83537.1 - 0.0032 17.2 0.2 0.029 14.1 0.0 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain HTH_AsnC-type PF13404.6 AIF83537.1 - 0.0049 16.7 0.0 0.37 10.6 0.0 2.9 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain zf-CCHC_5 PF14787.6 AIF83537.1 - 0.011 15.4 1.1 0.13 12.0 0.4 2.3 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger HTH_Tnp_ISL3 PF13542.6 AIF83537.1 - 0.016 14.6 0.2 1.4 8.4 0.0 3.2 4 0 0 4 4 4 0 Helix-turn-helix domain of transposase family ISL3 HTH_3 PF01381.22 AIF83537.1 - 0.027 14.5 0.0 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix Rrf2 PF02082.20 AIF83537.1 - 0.034 14.5 0.3 20 5.6 0.0 3.1 3 0 0 3 3 3 0 Transcriptional regulator RB_B PF01857.20 AIF83537.1 - 0.038 14.0 0.1 0.073 13.1 0.0 1.5 2 0 0 2 2 1 0 Retinoblastoma-associated protein B domain LacI PF00356.21 AIF83537.1 - 0.065 13.0 4.2 0.64 9.9 0.3 3.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family Sigma70_r4_2 PF08281.12 AIF83537.1 - 0.076 12.7 0.2 0.42 10.3 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 Phage_terminase PF10668.9 AIF83537.1 - 0.093 12.8 0.2 4.6 7.3 0.0 2.6 3 0 0 3 3 2 0 Phage terminase small subunit Ribosomal_S27e PF01667.17 AIF83537.1 - 0.1 12.3 0.2 0.26 11.0 0.2 1.6 1 0 0 1 1 1 0 Ribosomal protein S27 DZR PF12773.7 AIF83537.1 - 0.14 12.2 0.3 0.34 11.0 0.3 1.6 1 0 0 1 1 1 0 Double zinc ribbon MerR PF00376.23 AIF83537.1 - 0.14 11.9 0.1 1.5 8.6 0.0 2.5 2 0 0 2 2 2 0 MerR family regulatory protein Auto_anti-p27 PF06677.12 AIF83537.1 - 0.14 12.3 1.0 0.25 11.6 1.0 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Ribosomal_L37e PF01907.19 AIF83537.1 - 0.16 12.1 0.2 0.57 10.4 0.2 1.9 1 0 0 1 1 1 0 Ribosomal protein L37e OrfB_Zn_ribbon PF07282.11 AIF83537.1 - 0.18 11.8 1.3 0.42 10.6 1.3 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zinc_ribbon_2 PF13240.6 AIF83537.1 - 0.21 11.3 6.4 0.67 9.7 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 AIF83537.1 - 0.34 10.4 4.9 2.8 7.5 4.9 2.2 1 1 0 1 1 1 0 zinc-ribbon domain Rib_5-P_isom_A PF06026.14 AIF83540.1 - 3.6e-53 179.7 0.0 4.4e-53 179.4 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 AIF83540.1 - 3.4e-06 27.1 0.1 0.01 15.8 0.0 2.2 2 0 0 2 2 2 2 DeoR C terminal sensor domain Sugar-bind PF04198.13 AIF83540.1 - 0.0055 15.9 0.0 0.0083 15.3 0.0 1.3 1 0 0 1 1 1 1 Putative sugar-binding domain MscL PF01741.18 AIF83541.1 - 4.2e-22 78.7 3.0 4.7e-22 78.6 3.0 1.0 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL TrpP PF17099.5 AIF83541.1 - 0.00051 19.9 0.4 0.00051 19.9 0.4 1.9 1 1 1 2 2 2 1 Tryptophan transporter TrpP FtsX PF02687.21 AIF83541.1 - 0.0017 18.8 4.8 0.0026 18.2 4.8 1.3 1 0 0 1 1 1 1 FtsX-like permease family NPCC PF08058.11 AIF83541.1 - 0.043 13.9 0.6 0.054 13.6 0.6 1.1 1 0 0 1 1 1 0 Nuclear pore complex component DUF1449 PF07290.11 AIF83541.1 - 0.51 9.9 5.2 0.21 11.2 2.9 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1449) Amidohydro_1 PF01979.20 AIF83542.1 - 5.9e-23 81.7 0.2 1.2e-21 77.4 0.2 2.4 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 AIF83542.1 - 6.7e-15 55.5 0.2 2.9e-07 30.3 0.0 2.7 2 1 1 3 3 3 2 Amidohydrolase family Urease_alpha PF00449.20 AIF83542.1 - 7.9e-05 23.0 0.1 0.00024 21.4 0.1 1.8 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain zf-C3HC4_3 PF13920.6 AIF83543.1 - 0.0048 16.7 0.7 0.0065 16.3 0.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ribbon_3 PF13248.6 AIF83543.1 - 0.03 13.7 0.1 0.03 13.7 0.1 2.1 2 1 0 2 2 2 0 zinc-ribbon domain Polysacc_deac_1 PF01522.21 AIF83547.1 - 1.2e-11 44.6 0.0 1.7e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIF83547.1 - 3.6e-08 33.3 0.0 5.6e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_hydro_57 PF03065.15 AIF83547.1 - 6.3e-05 22.3 0.0 7.5e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 PAS_8 PF13188.7 AIF83547.1 - 0.0088 16.1 0.0 0.18 11.8 0.0 2.7 2 1 1 3 3 3 1 PAS domain CPSase_L_D2 PF02786.17 AIF83547.1 - 0.023 14.2 0.0 0.057 12.9 0.0 1.6 1 1 1 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain HTH_45 PF14947.6 AIF83548.1 - 1.6e-17 63.2 0.1 2e-17 62.9 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIF83548.1 - 0.0054 16.5 0.0 0.0058 16.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) DUF3102 PF11300.8 AIF83548.1 - 0.056 13.7 0.0 0.056 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3102) CHB_HEX_C_1 PF13290.6 AIF83549.1 - 1.9e-91 300.1 81.0 3.4e-21 75.0 6.4 7.6 8 0 0 8 8 8 5 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 AIF83549.1 - 1.6e-75 249.1 57.7 2.8e-16 59.4 5.1 6.4 6 0 0 6 6 6 5 Fn3 associated CHB_HEX_C PF03174.13 AIF83549.1 - 6.4e-18 64.5 4.6 0.0012 18.8 0.0 5.8 5 0 0 5 5 5 5 Chitobiase/beta-hexosaminidase C-terminal domain Polysacc_deac_1 PF01522.21 AIF83549.1 - 7.3e-12 45.3 0.0 2.7e-11 43.4 0.0 2.0 1 0 0 1 1 1 1 Polysaccharide deacetylase HYR PF02494.16 AIF83549.1 - 2.9e-10 40.3 21.1 9.8e-07 29.0 1.6 5.6 5 0 0 5 5 5 2 HYR domain CCDC24 PF15669.5 AIF83549.1 - 0.082 12.8 0.1 2.5 7.9 0.1 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family Qn_am_d_aIII PF09099.10 AIF83550.1 - 0.00028 21.2 2.9 0.65 10.4 0.8 2.8 2 0 0 2 2 2 2 Quinohemoprotein amine dehydrogenase, alpha subunit domain III TIG PF01833.24 AIF83550.1 - 0.0009 19.3 21.4 0.017 15.2 4.2 3.5 2 1 1 3 3 3 2 IPT/TIG domain MG2 PF01835.19 AIF83550.1 - 0.0017 18.8 3.2 0.039 14.4 0.1 2.9 3 0 0 3 3 3 1 MG2 domain Alph_Pro_TM PF09608.10 AIF83550.1 - 0.01 15.7 0.1 3.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Putative transmembrane protein (Alph_Pro_TM) NPCBM_assoc PF10633.9 AIF83550.1 - 0.016 15.4 0.7 0.016 15.4 0.7 4.6 3 2 1 4 4 4 0 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF4625 PF15418.6 AIF83550.1 - 0.018 15.3 0.1 0.88 9.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) DUF4112 PF13430.6 AIF83551.1 - 0.013 15.8 0.5 4.1 7.7 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4112) Dicistro_VP4 PF11492.8 AIF83551.1 - 0.09 12.8 0.5 3.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Cricket paralysis virus, VP4 Patatin PF01734.22 AIF83553.1 - 1.6e-12 48.0 0.0 1.5e-11 44.9 0.0 2.2 2 0 0 2 2 2 1 Patatin-like phospholipase Nucleoporin2 PF04096.14 AIF83553.1 - 0.089 12.9 0.2 0.17 12.0 0.2 1.4 1 0 0 1 1 1 0 Nucleoporin autopeptidase Response_reg PF00072.24 AIF83554.1 - 6.3e-22 77.9 0.2 9.2e-22 77.3 0.2 1.2 1 1 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 AIF83555.1 - 1.6e-23 83.3 1.8 4.2e-23 82.0 0.3 2.5 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIF83555.1 - 3.2e-12 46.3 3.1 3.9e-12 46.0 1.4 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 AIF83555.1 - 0.0013 18.7 0.3 0.009 16.0 0.0 2.5 3 0 0 3 3 3 1 Histidine kinase-like ATPase domain PLDc_2 PF13091.6 AIF83555.1 - 0.0081 16.0 1.0 0.33 10.8 0.0 3.4 4 0 0 4 4 4 1 PLD-like domain Response_reg PF00072.24 AIF83556.1 - 7.1e-18 64.8 0.0 2.2e-17 63.3 0.0 1.8 2 0 0 2 2 2 1 Response regulator receiver domain Guanylate_cyc PF00211.20 AIF83556.1 - 2.1e-11 43.8 0.0 3.3e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Response_reg PF00072.24 AIF83557.1 - 8.7e-21 74.2 0.1 1.3e-20 73.7 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HTH_45 PF14947.6 AIF83557.1 - 1.3e-06 28.3 0.1 2.6e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_24 PF13412.6 AIF83557.1 - 6.9e-05 22.3 0.0 0.00017 21.1 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF83557.1 - 0.1 12.4 0.0 0.38 10.6 0.0 2.0 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain SBP_bac_8 PF13416.6 AIF83558.1 - 5.3e-30 105.2 1.4 9.1e-30 104.4 1.4 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 AIF83558.1 - 4.3e-25 89.3 2.5 7.9e-25 88.5 2.5 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein HATPase_c PF02518.26 AIF83559.1 - 2.7e-23 82.6 0.1 6.1e-23 81.5 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIF83559.1 - 2.2e-14 53.2 2.0 2.9e-14 52.9 0.7 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain dCache_1 PF02743.18 AIF83559.1 - 3.6e-13 49.9 1.8 7.6e-13 48.8 1.0 1.9 2 0 0 2 2 2 1 Cache domain HATPase_c_5 PF14501.6 AIF83559.1 - 0.00025 20.9 0.2 0.00073 19.4 0.0 1.8 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.6 AIF83559.1 - 0.011 15.7 0.0 0.023 14.6 0.0 1.6 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain sCache_3_2 PF17203.4 AIF83559.1 - 0.13 12.4 0.9 3.4 7.8 0.1 3.3 3 1 0 3 3 3 0 Single cache domain 3 DUF4064 PF13273.6 AIF83559.1 - 0.26 11.6 2.5 1.6 9.0 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Csm1_N PF18504.1 AIF83560.1 - 0.035 14.4 0.3 0.97 9.8 0.0 2.5 2 1 0 2 2 2 0 Csm1 N-terminal domain HN PF00423.19 AIF83560.1 - 0.077 11.8 0.7 0.083 11.7 0.7 1.0 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase DUF5320 PF17253.2 AIF83560.1 - 0.1 13.7 0.1 0.39 11.8 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5320) zf-C2H2_2 PF12756.7 AIF83561.1 - 8.6e-06 26.0 0.5 9.4e-06 25.9 0.5 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 AIF83561.1 - 0.04 14.4 0.7 0.055 13.9 0.0 1.7 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 AIF83561.1 - 0.056 13.7 0.5 0.11 12.9 0.5 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AIF83561.1 - 0.064 13.7 0.2 0.11 12.9 0.2 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 AIF83561.1 - 0.078 13.9 0.1 0.18 12.7 0.1 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF83561.1 - 0.078 13.5 0.1 0.14 12.7 0.1 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF2228 PF10228.9 AIF83562.1 - 0.085 12.6 0.0 0.09 12.5 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) Malic_M PF03949.15 AIF83563.1 - 5.1e-26 91.5 0.7 6.8e-25 87.8 0.7 2.3 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 AIF83563.1 - 9.7e-21 74.4 2.8 4.4e-18 65.7 0.1 2.8 2 1 1 3 3 3 2 Malic enzyme, N-terminal domain AdoHcyase_NAD PF00670.21 AIF83563.1 - 0.00011 22.3 1.3 0.0076 16.3 0.0 3.0 3 0 0 3 3 3 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FAD_binding_3 PF01494.19 AIF83563.1 - 0.0018 17.6 0.1 0.0028 17.0 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Shikimate_DH PF01488.20 AIF83563.1 - 0.0036 17.4 0.1 0.29 11.2 0.1 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase ELFV_dehydrog PF00208.21 AIF83563.1 - 0.0044 16.8 2.4 0.0091 15.7 1.2 2.0 2 1 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase PglD_N PF17836.1 AIF83563.1 - 0.048 14.3 0.6 2.5 8.8 0.4 3.4 4 0 0 4 4 4 0 PglD N-terminal domain TrkA_N PF02254.18 AIF83563.1 - 0.081 13.2 0.7 0.52 10.6 0.1 2.6 2 1 0 2 2 2 0 TrkA-N domain 3HCDH_N PF02737.18 AIF83563.1 - 0.12 12.2 1.2 0.19 11.6 0.3 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-C2H2_4 PF13894.6 AIF83564.1 - 4.7e-07 30.1 9.5 0.00029 21.4 0.1 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF83564.1 - 1.7e-06 28.1 13.3 0.0017 18.7 0.4 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 AIF83564.1 - 2.4e-05 24.2 4.6 0.00027 20.8 0.5 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 AIF83564.1 - 0.004 17.8 3.7 0.5 11.1 1.6 2.0 1 1 1 2 2 2 2 Zinc finger C2H2-type, 3 repeats zinc_ribbon_5 PF13719.6 AIF83564.1 - 0.006 16.3 1.3 1.4 8.7 0.1 2.3 2 0 0 2 2 2 2 zinc-ribbon domain DUF629 PF04780.12 AIF83564.1 - 0.016 13.7 9.9 0.044 12.3 3.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) LIM PF00412.22 AIF83564.1 - 0.022 14.9 4.3 0.038 14.2 4.3 1.6 1 1 0 1 1 1 0 LIM domain zinc_ribbon_4 PF13717.6 AIF83564.1 - 0.025 14.5 3.5 0.33 10.9 3.5 2.2 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_15 PF17032.5 AIF83564.1 - 0.028 15.2 1.2 0.037 14.8 1.1 1.4 1 1 0 1 1 1 0 zinc-ribbon family zf-trcl PF13451.6 AIF83564.1 - 0.032 14.1 1.9 0.21 11.5 0.1 2.2 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf-LYAR PF08790.11 AIF83564.1 - 0.038 13.9 3.4 3.4 7.7 0.5 2.5 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger DNA_RNApol_7kD PF03604.13 AIF83564.1 - 0.048 13.3 1.6 0.098 12.4 0.2 2.1 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit RNA_POL_M_15KD PF02150.16 AIF83564.1 - 0.071 13.0 3.9 4.7 7.2 3.4 2.6 2 1 0 2 2 2 0 RNA polymerases M/15 Kd subunit zf-HYPF PF07503.12 AIF83564.1 - 0.085 12.7 3.7 0.31 10.8 1.0 2.4 2 0 0 2 2 2 0 HypF finger Zn-ribbon_8 PF09723.10 AIF83564.1 - 0.26 11.4 6.5 1.7 8.8 1.2 2.3 1 1 1 2 2 2 0 Zinc ribbon domain FOXP-CC PF16159.5 AIF83564.1 - 0.28 11.8 5.4 0.72 10.5 0.4 2.2 1 1 1 2 2 2 0 FOXP coiled-coil domain zf_UBZ PF18439.1 AIF83564.1 - 0.9 9.2 8.3 0.83 9.3 0.6 2.5 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger HTH_45 PF14947.6 AIF83566.1 - 2.6e-09 36.9 0.0 2.8e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_24 PF13412.6 AIF83566.1 - 0.016 14.7 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding RQC PF09382.10 AIF83566.1 - 0.05 13.4 0.0 0.062 13.1 0.0 1.1 1 0 0 1 1 1 0 RQC domain DUF2207 PF09972.9 AIF83567.1 - 0.026 13.3 0.0 0.028 13.2 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CBP4 PF07960.11 AIF83567.1 - 0.029 14.2 1.9 0.03 14.2 0.4 1.6 1 1 1 2 2 2 0 CBP4 Phage_holin_3_6 PF07332.11 AIF83567.1 - 0.82 9.7 4.1 1.9 8.5 4.1 1.6 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Zip PF02535.22 AIF83569.1 - 1.7e-05 24.2 23.2 0.00015 21.1 10.2 2.6 2 1 0 2 2 2 2 ZIP Zinc transporter AzlD PF05437.12 AIF83569.1 - 0.0048 17.0 4.6 0.0048 17.0 4.6 2.8 3 0 0 3 3 3 2 Branched-chain amino acid transport protein (AzlD) PEMT PF04191.13 AIF83569.1 - 4 7.9 8.1 4.8 7.6 0.8 3.1 3 0 0 3 3 3 0 Phospholipid methyltransferase dCMP_cyt_deam_1 PF00383.23 AIF83570.1 - 8.3e-05 22.4 0.0 0.00018 21.3 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AIF83570.1 - 0.0035 17.1 0.1 0.0063 16.3 0.1 1.4 1 0 0 1 1 1 1 MafB19-like deaminase OTT_1508_deam PF14441.6 AIF83570.1 - 0.062 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 OTT_1508-like deaminase SurA_N_3 PF13624.6 AIF83571.1 - 0.048 13.5 0.8 0.72 9.6 0.4 2.0 2 0 0 2 2 2 0 SurA N-terminal domain ETRAMP PF09716.10 AIF83571.1 - 0.19 11.8 2.1 0.29 11.2 2.1 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) dCache_1 PF02743.18 AIF83572.1 - 1.1e-17 64.6 0.1 1.3e-17 64.4 0.1 1.1 1 0 0 1 1 1 1 Cache domain sCache_3_3 PF17202.4 AIF83572.1 - 0.11 12.9 0.1 0.89 10.0 0.0 2.5 1 1 2 3 3 3 0 Single cache domain 3 Med21 PF11221.8 AIF83572.1 - 0.11 12.7 0.7 0.26 11.5 0.1 1.8 1 1 1 2 2 2 0 Subunit 21 of Mediator complex DUF2749 PF10907.8 AIF83572.1 - 2.1 8.6 4.6 5.8 7.2 0.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) dCache_1 PF02743.18 AIF83573.1 - 1.7e-19 70.6 0.2 2.1e-19 70.3 0.2 1.1 1 0 0 1 1 1 1 Cache domain dCache_3 PF14827.6 AIF83573.1 - 0.1 12.2 0.0 0.41 10.3 0.0 1.9 2 0 0 2 2 2 0 Double sensory domain of two-component sensor kinase Acetyltransf_18 PF18014.1 AIF83574.1 - 7.8e-30 103.3 0.0 1.7e-29 102.2 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AIF83574.1 - 5.9e-10 39.4 0.1 2e-08 34.5 0.0 2.6 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AIF83574.1 - 8e-06 26.2 0.3 1.7e-05 25.2 0.3 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AIF83574.1 - 2.9e-05 24.0 0.0 0.00016 21.6 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AIF83574.1 - 0.0014 18.6 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 AIF83574.1 - 0.055 13.6 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Pribosyltran PF00156.27 AIF83575.1 - 2.4e-11 43.4 0.1 1.1e-10 41.3 0.1 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain zinc_ribbon_4 PF13717.6 AIF83576.1 - 0.0013 18.7 3.5 0.0029 17.5 3.5 1.6 1 1 0 1 1 1 1 zinc-ribbon domain Zn_Tnp_IS1 PF03811.13 AIF83576.1 - 0.0013 18.4 0.4 0.002 17.8 0.4 1.3 1 1 0 1 1 1 1 InsA N-terminal domain UPF0515 PF15135.6 AIF83576.1 - 0.0018 17.7 1.4 0.0018 17.7 1.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein UPF0515 Zn_Tnp_IS1595 PF12760.7 AIF83576.1 - 0.0025 17.7 1.7 0.0027 17.6 1.7 1.1 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Rubredoxin_2 PF18073.1 AIF83576.1 - 0.017 14.8 5.7 0.054 13.2 0.2 2.1 2 0 0 2 2 2 0 Rubredoxin metal binding domain OrfB_Zn_ribbon PF07282.11 AIF83576.1 - 0.08 12.9 0.9 0.1 12.5 0.9 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zinc_ribbon_5 PF13719.6 AIF83576.1 - 1.3 8.8 7.1 7.8 6.4 7.1 1.9 1 1 0 1 1 1 0 zinc-ribbon domain TFIIS_C PF01096.18 AIF83576.1 - 2.1 8.3 8.1 5.3 7.0 0.6 2.1 1 1 2 3 3 3 0 Transcription factor S-II (TFIIS) MIase PF02426.16 AIF83580.1 - 1.2e-19 70.2 0.2 3.2e-19 68.9 0.1 1.6 2 0 0 2 2 2 1 Muconolactone delta-isomerase Ribosom_S30AE_C PF16321.5 AIF83580.1 - 0.046 13.4 0.1 0.071 12.8 0.1 1.3 1 0 0 1 1 1 0 Sigma 54 modulation/S30EA ribosomal protein C terminus YCII PF03795.14 AIF83580.1 - 0.055 13.9 0.0 0.077 13.4 0.0 1.4 1 0 0 1 1 1 0 YCII-related domain Hemerythrin PF01814.23 AIF83581.1 - 1.6e-14 54.7 0.3 3.6e-14 53.5 0.1 1.7 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain GFA PF04828.14 AIF83582.1 - 0.0097 16.2 0.3 0.8 10.1 0.1 2.1 1 1 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme ADK_lid PF05191.14 AIF83582.1 - 0.05 13.6 0.9 0.25 11.4 0.2 2.1 2 0 0 2 2 2 0 Adenylate kinase, active site lid PDZ_2 PF13180.6 AIF83583.1 - 1.7e-15 57.1 1.0 2.5e-07 30.9 0.2 2.2 1 1 1 2 2 2 2 PDZ domain PDZ_6 PF17820.1 AIF83583.1 - 3.2e-14 52.5 2.1 3e-06 27.0 0.6 2.4 1 1 1 2 2 2 2 PDZ domain PDZ PF00595.24 AIF83583.1 - 8.8e-10 38.8 1.2 7e-05 23.1 0.1 2.2 1 1 1 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 AIF83583.1 - 0.00017 21.5 0.4 0.027 14.4 0.0 2.4 1 1 1 2 2 2 2 Tricorn protease PDZ domain GRASP55_65 PF04495.14 AIF83583.1 - 0.067 13.5 0.0 0.28 11.5 0.0 2.0 1 1 1 2 2 2 0 GRASP55/65 PDZ-like domain Aminotran_3 PF00202.21 AIF83584.1 - 2.5e-89 299.8 0.0 3.2e-89 299.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 AIF83584.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Acyl-CoA_dh_1 PF00441.24 AIF83585.1 - 1.3e-32 113.1 6.2 1.8e-31 109.3 4.5 2.4 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 AIF83585.1 - 4.4e-22 78.1 0.2 8.8e-22 77.1 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 AIF83585.1 - 2.1e-20 73.5 0.5 6.1e-20 72.0 0.0 2.1 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 AIF83585.1 - 5e-10 39.8 10.1 4.8e-09 36.6 10.1 2.2 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HATPase_c_3 PF13589.6 AIF83585.1 - 0.023 14.5 0.1 0.047 13.5 0.1 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MaoC_dehydratas PF01575.19 AIF83586.1 - 4.7e-05 22.9 0.0 0.00081 19.0 0.0 2.1 1 1 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 AIF83586.1 - 0.007 16.5 0.0 0.012 15.8 0.0 1.3 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase LpxC PF03331.13 AIF83586.1 - 0.1 12.0 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 UDP-3-O-acyl N-acetylglycosamine deacetylase DUF4423 PF14394.6 AIF83588.1 - 0.00098 18.9 0.4 0.29 10.8 0.1 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4423) HTH_45 PF14947.6 AIF83588.1 - 0.045 13.7 0.1 0.093 12.7 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix PLDc_2 PF13091.6 AIF83589.1 - 0.0081 16.1 1.1 0.05 13.5 0.2 2.5 3 0 0 3 3 3 1 PLD-like domain UbiA PF01040.18 AIF83590.1 - 1.4e-33 116.2 12.9 1.9e-33 115.9 12.9 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Ldr_toxin PF13940.6 AIF83590.1 - 1.7 8.8 6.2 0.81 9.8 0.3 3.1 2 0 0 2 2 2 0 Toxin Ldr, type I toxin-antitoxin system DUF2070 PF09843.9 AIF83590.1 - 5.3 5.2 16.7 15 3.7 16.8 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) UbiA PF01040.18 AIF83592.1 - 3.2e-33 115.1 12.7 3.2e-33 115.1 12.7 1.4 1 1 0 1 1 1 1 UbiA prenyltransferase family MmgE_PrpD PF03972.14 AIF83593.1 - 5.6e-47 160.3 0.0 1.3e-46 159.1 0.0 1.4 1 1 0 1 1 1 1 MmgE/PrpD family Pectate_lyase_3 PF12708.7 AIF83594.1 - 0.0012 18.7 0.1 0.0026 17.6 0.0 1.5 1 1 0 1 1 1 1 Pectate lyase superfamily protein Cupin_2 PF07883.11 AIF83594.1 - 0.017 14.8 0.0 0.037 13.7 0.0 1.5 1 0 0 1 1 1 0 Cupin domain AraC_binding PF02311.19 AIF83594.1 - 0.026 14.4 0.0 0.038 13.9 0.0 1.2 1 0 0 1 1 1 0 AraC-like ligand binding domain DZR PF12773.7 AIF83595.1 - 0.0014 18.6 1.6 0.0019 18.2 1.6 1.2 1 0 0 1 1 1 1 Double zinc ribbon DNA_ligase_ZBD PF03119.16 AIF83595.1 - 0.007 16.4 2.3 2.1 8.4 0.1 2.4 2 0 0 2 2 2 2 NAD-dependent DNA ligase C4 zinc finger domain zinc_ribbon_2 PF13240.6 AIF83595.1 - 0.026 14.2 7.5 0.48 10.2 7.1 2.1 1 1 1 2 2 2 0 zinc-ribbon domain DUF1272 PF06906.11 AIF83595.1 - 0.027 14.5 1.5 0.039 14.0 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) TMEM208_SND2 PF05620.11 AIF83595.1 - 0.052 13.3 0.1 0.062 13.1 0.1 1.1 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DUF2207 PF09972.9 AIF83595.1 - 0.059 12.1 0.8 0.068 11.9 0.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Zn-ribbon_8 PF09723.10 AIF83595.1 - 0.061 13.5 3.6 0.17 12.0 3.6 1.7 1 1 0 1 1 1 0 Zinc ribbon domain HypA PF01155.19 AIF83595.1 - 0.075 13.1 0.5 0.096 12.7 0.5 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 AIF83595.1 - 0.13 11.7 7.2 0.14 11.6 1.2 2.1 1 1 0 1 1 1 0 zinc-ribbon domain zf-NADH-PPase PF09297.11 AIF83595.1 - 0.15 11.7 3.3 1.3 8.7 0.5 2.3 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DUF1610 PF07754.11 AIF83595.1 - 0.15 12.0 7.6 1.9 8.5 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zf-ISL3 PF14690.6 AIF83595.1 - 0.22 12.2 3.4 1.2 9.9 0.5 2.5 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 PolC_DP2 PF03833.13 AIF83595.1 - 0.24 9.2 0.5 0.28 9.0 0.5 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-IS66 PF13005.7 AIF83595.1 - 0.45 11.0 2.3 0.63 10.5 0.1 2.1 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 Sgf11 PF08209.11 AIF83595.1 - 0.52 9.9 0.2 0.52 9.9 0.2 2.2 1 1 1 2 2 2 0 Sgf11 (transcriptional regulation protein) zf-RRN7 PF11781.8 AIF83595.1 - 0.63 9.8 7.0 2.2 8.0 2.5 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TF_Zn_Ribbon PF08271.12 AIF83595.1 - 0.93 9.1 6.5 2.3 7.8 0.9 2.0 1 1 1 2 2 2 0 TFIIB zinc-binding Prim_Zn_Ribbon PF08273.12 AIF83595.1 - 1.1 9.7 9.3 2.1 8.7 0.9 2.9 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase Rubredoxin_2 PF18073.1 AIF83595.1 - 6.8 6.5 8.0 3.7 7.3 5.4 2.0 2 1 0 2 2 2 0 Rubredoxin metal binding domain C1_4 PF07975.12 AIF83596.1 - 0.0036 17.5 0.8 0.0036 17.5 0.8 1.1 1 0 0 1 1 1 1 TFIIH C1-like domain IMS PF00817.20 AIF83597.1 - 2.5e-42 144.4 0.1 5.2e-42 143.4 0.1 1.6 1 0 0 1 1 1 1 impB/mucB/samB family DUF72 PF01904.18 AIF83597.1 - 7.1e-22 78.6 0.0 1.3e-21 77.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF72 IMS_C PF11799.8 AIF83597.1 - 3.6e-12 47.0 0.0 6.7e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 AIF83597.1 - 2.8e-07 30.5 0.1 5.9e-07 29.5 0.1 1.6 1 0 0 1 1 1 1 IMS family HHH motif HHH_5 PF14520.6 AIF83597.1 - 0.00037 21.0 0.1 0.00093 19.8 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF4332 PF14229.6 AIF83597.1 - 0.036 14.3 0.0 0.098 12.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4332) Cdd1 PF11731.8 AIF83597.1 - 0.065 13.5 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Pathogenicity locus Pro_isomerase PF00160.21 AIF83599.1 - 6.4e-53 179.3 0.2 8e-53 178.9 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD BKACE PF05853.12 AIF83599.1 - 0.058 12.7 0.0 4.2 6.6 0.0 2.1 2 0 0 2 2 2 0 beta-keto acid cleavage enzyme TetR_N PF00440.23 AIF83600.1 - 4.7e-18 64.7 0.0 9.6e-18 63.7 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.6 AIF83600.1 - 3.7e-12 46.5 0.0 6.1e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 BetI-type transcriptional repressor, C-terminal TetR_C_31 PF17940.1 AIF83600.1 - 0.00031 20.9 0.1 0.00079 19.6 0.1 1.7 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_11 PF16859.5 AIF83600.1 - 0.00066 20.0 0.0 0.0011 19.3 0.0 1.4 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_7 PF14246.6 AIF83600.1 - 0.011 15.7 0.1 0.039 14.0 0.0 1.8 2 0 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain TetR_C_17 PF17922.1 AIF83600.1 - 0.031 14.4 0.0 0.074 13.2 0.0 1.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 AIF83600.1 - 0.059 13.5 0.3 0.41 10.8 0.0 2.3 2 1 1 3 3 3 0 Helix-turn-helix of insertion element transposase RVT_3 PF13456.6 AIF83601.1 - 6.1e-19 68.0 0.0 6.8e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase-like RNase_H PF00075.24 AIF83601.1 - 5.3e-09 36.4 0.0 8.9e-09 35.7 0.0 1.3 1 1 0 1 1 1 1 RNase H SurA_N_3 PF13624.6 AIF83602.1 - 0.043 13.6 0.2 0.044 13.6 0.2 1.0 1 0 0 1 1 1 0 SurA N-terminal domain Cupin_2 PF07883.11 AIF83603.1 - 4.5e-20 71.1 0.0 6.8e-20 70.6 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 AIF83603.1 - 9.4e-06 25.6 0.0 1.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 AIF83603.1 - 9.4e-05 22.1 0.0 0.00017 21.2 0.0 1.5 1 0 0 1 1 1 1 Cupin Auxin_BP PF02041.16 AIF83603.1 - 0.0001 22.0 0.0 0.00028 20.6 0.0 1.7 1 1 0 1 1 1 1 Auxin binding protein Cupin_3 PF05899.12 AIF83603.1 - 0.0044 16.7 0.0 0.0069 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) EutQ PF06249.12 AIF83603.1 - 0.011 15.5 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutQ DMSP_lyase PF16867.5 AIF83603.1 - 0.013 15.1 0.1 0.042 13.5 0.1 1.7 2 0 0 2 2 2 0 Dimethlysulfonioproprionate lyase CENP-C_C PF11699.8 AIF83603.1 - 0.05 13.8 0.0 0.075 13.3 0.0 1.2 1 0 0 1 1 1 0 Mif2/CENP-C like MannoseP_isomer PF01050.18 AIF83603.1 - 0.072 13.0 0.0 0.099 12.5 0.0 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Seryl_tRNA_N PF02403.22 AIF83604.1 - 0.01 16.0 0.5 0.011 15.9 0.5 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Csm1_N PF18504.1 AIF83604.1 - 0.03 14.7 0.6 0.035 14.4 0.6 1.2 1 0 0 1 1 1 0 Csm1 N-terminal domain 60KD_IMP PF02096.20 AIF83604.1 - 0.13 12.1 0.3 0.13 12.1 0.3 1.0 1 0 0 1 1 1 0 60Kd inner membrane protein FAM76 PF16046.5 AIF83604.1 - 0.3 10.4 2.4 0.31 10.3 2.4 1.0 1 0 0 1 1 1 0 FAM76 protein SIMPL PF04402.14 AIF83605.1 - 1.3e-43 149.8 6.0 1.7e-43 149.4 6.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF541) DUF4834 PF16118.5 AIF83605.1 - 0.068 14.1 0.1 0.15 13.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Aldo_ket_red PF00248.21 AIF83605.1 - 0.074 12.2 0.3 1 8.5 0.0 2.0 2 0 0 2 2 2 0 Aldo/keto reductase family Hormone_6 PF00236.18 AIF83605.1 - 0.13 12.3 0.2 0.29 11.2 0.1 1.7 1 1 0 1 1 1 0 Glycoprotein hormone Beta_propel PF09826.9 AIF83606.1 - 8.6e-150 500.0 11.9 1e-149 499.7 11.9 1.0 1 0 0 1 1 1 1 Beta propeller domain LVIVD PF08309.11 AIF83606.1 - 0.1 11.9 4.6 15 5.0 0.0 4.1 4 0 0 4 4 4 0 LVIVD repeat T2SSF PF00482.23 AIF83607.1 - 0.062 13.2 0.9 0.69 9.9 0.9 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F SR-25 PF10500.9 AIF83607.1 - 0.21 11.2 3.2 0.3 10.6 3.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Exonuc_VII_L PF02601.15 AIF83608.1 - 0.079 12.5 11.2 0.088 12.4 11.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit CorA PF01544.18 AIF83608.1 - 0.09 12.1 0.3 0.12 11.6 0.3 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein bZIP_1 PF00170.21 AIF83608.1 - 0.24 11.5 0.3 0.24 11.5 0.3 3.3 1 1 2 3 3 3 0 bZIP transcription factor DUF2951 PF11166.8 AIF83608.1 - 0.26 11.5 2.2 0.27 11.5 0.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2951) DASH_Duo1 PF08651.10 AIF83608.1 - 0.31 10.8 3.1 0.22 11.3 0.6 2.0 2 1 0 2 2 2 0 DASH complex subunit Duo1 BLOC1_2 PF10046.9 AIF83608.1 - 0.34 11.2 6.7 0.39 11.0 2.9 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2721 PF11026.8 AIF83608.1 - 0.63 9.9 1.7 1.2 9.0 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) XkdW PF09636.10 AIF83608.1 - 0.65 10.1 5.8 0.57 10.3 1.7 2.2 1 1 1 2 2 2 0 XkdW protein KASH_CCD PF14662.6 AIF83608.1 - 1 9.2 13.7 2.8 7.7 13.6 1.6 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH KxDL PF10241.9 AIF83608.1 - 1.6 9.1 9.1 0.06 13.6 3.4 1.5 2 0 0 2 2 1 0 Uncharacterized conserved protein Jnk-SapK_ap_N PF09744.9 AIF83608.1 - 1.8 8.8 12.0 16 5.7 12.0 2.0 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 APG6_N PF17675.1 AIF83608.1 - 6.2 7.4 12.7 21 5.6 12.7 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF1690 PF07956.11 AIF83608.1 - 9 6.7 13.9 1.9 8.9 8.9 1.8 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) TMPIT PF07851.13 AIF83608.1 - 9.3 5.4 8.7 3.1 7.0 6.1 1.4 1 1 0 1 1 1 0 TMPIT-like protein Copper-bind PF00127.20 AIF83609.1 - 1.8e-06 28.3 0.2 0.025 15.0 0.0 2.7 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF83609.1 - 0.0071 16.4 0.4 0.33 11.1 0.0 2.5 2 1 0 2 2 2 1 Cupredoxin-like domain DXPR_C PF13288.6 AIF83609.1 - 0.15 12.4 0.1 0.29 11.4 0.1 1.5 1 0 0 1 1 1 0 DXP reductoisomerase C-terminal domain DUF1451 PF07295.11 AIF83610.1 - 0.0043 17.1 0.5 0.0044 17.1 0.5 1.2 1 0 0 1 1 1 1 Zinc-ribbon containing domain A2L_zn_ribbon PF08792.10 AIF83610.1 - 0.017 14.8 1.8 0.61 9.9 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain zf_UBZ PF18439.1 AIF83610.1 - 0.22 11.1 1.2 1.5 8.5 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DZR PF12773.7 AIF83611.1 - 0.0088 16.0 6.5 0.0088 16.0 6.5 1.7 1 1 0 1 1 1 1 Double zinc ribbon Ribosomal_L32p PF01783.23 AIF83611.1 - 0.011 15.9 1.8 0.011 15.9 1.8 2.1 1 1 1 2 2 2 0 Ribosomal L32p protein family PolC_DP2 PF03833.13 AIF83611.1 - 0.22 9.3 2.2 0.22 9.3 2.2 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DUF35_N PF12172.8 AIF83611.1 - 0.71 9.8 8.9 0.1 12.5 3.5 2.2 1 1 1 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-Sec23_Sec24 PF04810.15 AIF83611.1 - 2 8.5 7.0 1.5 8.9 4.6 2.2 1 1 1 2 2 2 0 Sec23/Sec24 zinc finger Jas PF16135.5 AIF83613.1 - 0.025 14.7 1.0 0.23 11.7 1.0 2.0 1 1 0 1 1 1 0 TPL-binding domain in jasmonate signalling HypA PF01155.19 AIF83613.1 - 0.034 14.2 0.2 0.039 14.0 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_12 PF18658.1 AIF83613.1 - 0.036 13.6 0.2 0.051 13.1 0.1 1.5 1 1 0 1 1 1 0 Zinc-finger C2H2-type FlgD_ig PF13860.6 AIF83614.1 - 2.9e-14 52.7 2.0 2.9e-14 52.7 2.0 2.4 2 1 0 2 2 2 1 FlgD Ig-like domain CHU_C PF13585.6 AIF83614.1 - 0.00019 21.4 0.0 0.00037 20.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of CHU protein family DUF2271 PF10029.9 AIF83614.1 - 0.0098 15.5 0.5 0.048 13.3 0.3 2.1 1 1 1 2 2 2 1 Predicted periplasmic protein (DUF2271) N6_N4_Mtase PF01555.18 AIF83615.1 - 2.3e-41 142.0 0.0 3.2e-41 141.5 0.0 1.2 1 0 0 1 1 1 1 DNA methylase Methyltransf_25 PF13649.6 AIF83615.1 - 9.8e-05 23.0 0.0 0.0022 18.6 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF83615.1 - 0.00038 20.3 0.0 0.0017 18.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF83615.1 - 0.0018 18.9 0.1 0.58 10.8 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 AIF83615.1 - 0.0027 17.4 0.2 0.98 9.1 0.2 2.7 2 1 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.12 AIF83615.1 - 0.042 14.6 0.0 0.82 10.5 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain RSB_motif PF16294.5 AIF83615.1 - 0.12 12.7 0.4 0.24 11.7 0.4 1.4 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif Methyltransf_15 PF09445.10 AIF83615.1 - 0.13 11.9 0.1 0.29 10.7 0.0 1.6 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase MTS PF05175.14 AIF83615.1 - 0.15 11.6 0.0 4 7.0 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain YqgC PF17430.2 AIF83616.1 - 0.081 13.0 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized YqgC-like YjeF_N PF03853.15 AIF83618.1 - 5.6e-44 150.0 0.1 7.5e-44 149.6 0.1 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus DUF429 PF04250.13 AIF83618.1 - 0.054 13.3 0.0 0.094 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF429) Lactamase_B PF00753.27 AIF83619.1 - 2.2e-20 73.5 1.4 2.2e-19 70.3 1.4 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AIF83619.1 - 0.00042 19.9 0.0 0.0011 18.5 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_5 PF14597.6 AIF83619.1 - 0.00082 18.9 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily CBP_BcsG PF11658.8 AIF83619.1 - 0.17 10.2 0.0 0.23 9.8 0.0 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DBI_PRT PF02277.17 AIF83620.1 - 3.4e-11 42.9 6.2 4.9e-11 42.4 6.2 1.2 1 0 0 1 1 1 1 Phosphoribosyltransferase DUF4292 PF14125.6 AIF83621.1 - 0.0086 15.8 0.2 0.06 13.0 0.1 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4292) Pur_DNA_glyco PF02245.16 AIF83622.1 - 2.2e-63 212.9 0.0 2.5e-63 212.7 0.0 1.0 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) UDG PF03167.19 AIF83623.1 - 1.5e-46 158.2 0.0 1.9e-46 157.9 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily DUF202 PF02656.15 AIF83624.1 - 0.03 14.8 0.1 0.044 14.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Phage_holin_3_6 PF07332.11 AIF83624.1 - 0.051 13.6 1.8 0.093 12.8 1.8 1.6 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Gram_pos_anchor PF00746.21 AIF83624.1 - 0.087 12.8 4.4 1.9 8.5 0.1 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Transglut_core2 PF13369.6 AIF83625.1 - 1.1e-41 141.9 0.0 1.9e-41 141.2 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily TPR_9 PF13371.6 AIF83625.1 - 6.5e-12 45.4 0.1 1.2e-11 44.6 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 AIF83625.1 - 0.048 14.5 0.0 0.15 13.0 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 AIF83625.1 - 0.072 13.6 0.4 0.16 12.5 0.4 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat HHH_5 PF14520.6 AIF83625.1 - 0.075 13.6 0.0 0.16 12.6 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain TPR_16 PF13432.6 AIF83625.1 - 0.097 13.3 0.2 0.26 12.0 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Ammonium_transp PF00909.21 AIF83626.1 - 2.9e-117 391.7 33.9 4.3e-117 391.2 33.9 1.3 1 0 0 1 1 1 1 Ammonium Transporter Family Na_H_Exchanger PF00999.21 AIF83628.1 - 1.1e-59 202.2 58.6 1.4e-59 201.8 58.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Frankia_peptide PF14407.6 AIF83629.1 - 0.00091 19.2 0.0 0.0013 18.7 0.0 1.3 1 1 0 1 1 1 1 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. LigA PF07746.11 AIF83629.1 - 0.084 13.0 0.0 0.096 12.8 0.0 1.1 1 0 0 1 1 1 0 Aromatic-ring-opening dioxygenase LigAB, LigA subunit NHase_alpha PF02979.16 AIF83629.1 - 0.1 11.9 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Nitrile hydratase, alpha chain HhH-GPD PF00730.25 AIF83630.1 - 3.8e-11 43.4 0.0 5.6e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein OGG_N PF07934.12 AIF83630.1 - 7.6e-10 38.9 0.0 8.1e-09 35.6 0.0 2.1 1 1 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HHH PF00633.23 AIF83630.1 - 0.00037 20.2 0.0 0.00086 19.1 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.7 AIF83630.1 - 0.00049 20.1 0.0 0.14 12.3 0.0 3.3 3 0 0 3 3 3 1 Helix-hairpin-helix motif HHH_3 PF12836.7 AIF83630.1 - 0.036 14.3 0.0 0.68 10.2 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif HHH_5 PF14520.6 AIF83630.1 - 0.13 12.9 0.0 0.67 10.6 0.1 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix domain Ribosomal_L40e PF01020.17 AIF83632.1 - 0.0017 18.2 7.6 0.002 17.9 7.6 1.2 1 0 0 1 1 1 1 Ribosomal L40e family zinc_ribbon_2 PF13240.6 AIF83632.1 - 0.011 15.4 1.9 0.018 14.8 1.9 1.3 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.7 AIF83632.1 - 0.013 15.5 1.2 0.015 15.3 1.2 1.2 1 0 0 1 1 1 0 Double zinc ribbon zf-CCHC PF00098.23 AIF83632.1 - 0.023 14.8 3.7 0.057 13.5 0.2 2.3 2 0 0 2 2 2 0 Zinc knuckle HypA PF01155.19 AIF83632.1 - 0.044 13.8 0.7 0.048 13.7 0.7 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DNA_RNApol_7kD PF03604.13 AIF83632.1 - 0.074 12.7 5.7 0.17 11.6 5.7 1.6 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Paired_CXXCH_1 PF09699.10 AIF83632.1 - 0.4 10.5 7.4 0.38 10.5 2.6 2.1 1 1 1 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) AbrB-like PF14250.6 AIF83633.1 - 0.088 12.9 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 AbrB-like transcriptional regulator Abhydrolase_1 PF00561.20 AIF83634.1 - 1.4e-35 123.2 0.0 4.4e-26 92.1 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIF83634.1 - 2.6e-23 83.8 0.0 3e-23 83.6 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AIF83634.1 - 1.9e-16 60.1 0.0 2.5e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 AIF83634.1 - 0.00012 22.1 0.0 0.00028 20.8 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 AIF83634.1 - 0.0016 18.3 0.0 0.28 11.0 0.0 2.3 2 0 0 2 2 2 2 Serine hydrolase Abhydrolase_2 PF02230.16 AIF83634.1 - 0.013 15.3 0.0 1.5 8.6 0.0 2.5 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Ndr PF03096.14 AIF83634.1 - 0.016 13.9 0.0 0.046 12.4 0.0 1.6 1 1 0 1 1 1 0 Ndr family UPF0227 PF05728.12 AIF83634.1 - 0.022 14.7 0.0 0.055 13.4 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Abhydrolase_5 PF12695.7 AIF83634.1 - 0.061 13.1 0.0 4 7.2 0.0 2.3 2 1 0 2 2 2 0 Alpha/beta hydrolase family HTH_45 PF14947.6 AIF83636.1 - 5.9e-19 67.8 0.1 8.6e-19 67.3 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIF83636.1 - 0.0029 17.4 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) RQC PF09382.10 AIF83636.1 - 0.028 14.2 0.1 0.16 11.7 0.0 1.9 1 1 1 2 2 2 0 RQC domain zf-ribbon_3 PF13248.6 AIF83637.1 - 0.0027 17.1 1.4 1.6 8.2 0.2 2.2 2 0 0 2 2 2 2 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIF83637.1 - 0.017 15.0 0.6 0.027 14.4 0.6 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DZR PF12773.7 AIF83637.1 - 0.056 13.5 0.3 0.079 13.0 0.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 AIF83637.1 - 0.6 10.3 3.7 13 6.0 0.1 2.2 1 1 1 2 2 2 0 Zinc ribbon domain zinc_ribbon_10 PF10058.9 AIF83637.1 - 0.63 9.8 3.4 1.5 8.6 3.4 1.6 1 1 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-RRN7 PF11781.8 AIF83637.1 - 0.64 9.7 7.7 5.6 6.7 7.7 2.1 1 1 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Prim_Zn_Ribbon PF08273.12 AIF83637.1 - 3.1 8.2 8.3 9.6 6.6 8.3 1.8 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase Zn_ribbon_recom PF13408.6 AIF83637.1 - 3.3 8.3 6.4 6.3 7.4 6.4 1.7 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain DUF2848 PF11010.8 AIF83638.1 - 0.074 12.6 0.0 0.076 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2848) Copper-bind PF00127.20 AIF83639.1 - 4.2e-11 43.2 0.1 5.5e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF83639.1 - 2.9e-05 24.1 0.0 6.2e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 Cupredoxin-like domain Cytochrome_B PF00033.19 AIF83640.1 - 2.2e-26 92.9 12.2 2.2e-26 92.9 12.2 2.2 3 0 0 3 3 3 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 AIF83640.1 - 1e-24 87.5 8.8 1e-24 87.5 8.8 3.3 3 1 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.17 AIF83640.1 - 7.3e-09 35.9 2.3 7.3e-09 35.9 2.3 3.6 5 1 1 6 6 6 1 Cytochrome b(C-terminal)/b6/petD DUF4405 PF14358.6 AIF83640.1 - 0.0064 17.0 3.4 0.0064 17.0 3.4 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF4405) UPF0542 PF15086.6 AIF83640.1 - 0.013 15.4 2.2 0.019 14.9 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 Phage_holin_3_6 PF07332.11 AIF83640.1 - 0.023 14.7 0.1 0.023 14.7 0.1 4.0 4 1 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III Rieske PF00355.26 AIF83641.1 - 1.2e-06 28.4 0.0 1.8e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain TAT_signal PF10518.9 AIF83641.1 - 6.2e-05 22.7 0.3 0.00011 21.8 0.3 1.4 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.9 AIF83641.1 - 0.0057 16.0 0.1 0.011 15.0 0.1 1.5 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Pentapeptide PF00805.22 AIF83642.1 - 3.2e-29 100.1 16.3 5.1e-11 42.0 1.5 4.5 2 1 4 6 6 6 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 AIF83642.1 - 1.8e-19 69.6 3.3 7e-09 35.7 0.2 2.8 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 AIF83642.1 - 2.2e-11 43.7 3.5 0.00019 21.5 0.1 3.3 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) TP_methylase PF00590.20 AIF83643.1 - 1.3e-20 74.3 0.2 4.8e-20 72.4 0.0 1.9 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF357 PF04010.13 AIF83643.1 - 1.6e-16 60.1 0.6 2e-15 56.6 0.4 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF357) G-alpha PF00503.20 AIF83643.1 - 0.23 10.6 0.0 0.25 10.4 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit Peptidase_M20 PF01546.28 AIF83644.1 - 1.3e-28 100.2 0.1 2.3e-28 99.3 0.1 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AIF83644.1 - 1.1e-13 51.1 0.0 2.1e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 AIF83644.1 - 3.8e-05 23.5 0.0 0.00028 20.6 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M42 PF05343.14 AIF83644.1 - 0.0018 17.4 0.2 0.33 9.9 0.0 2.8 3 1 1 4 4 4 2 M42 glutamyl aminopeptidase Rimk_N PF18030.1 AIF83644.1 - 0.073 13.5 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 RimK PreATP-grasp domain RimK PF08443.11 AIF83645.1 - 1.6e-31 109.4 0.0 2.5e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 AIF83645.1 - 5.7e-08 32.4 0.0 8.2e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.14 AIF83645.1 - 8e-07 29.2 0.0 1.4e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 AIF83645.1 - 9.2e-07 28.6 0.1 3.7e-06 26.6 0.1 2.0 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_ST PF14397.6 AIF83645.1 - 3.7e-05 23.1 0.0 0.015 14.6 0.0 2.6 2 1 1 3 3 3 2 Sugar-transfer associated ATP-grasp ATP-grasp PF02222.22 AIF83645.1 - 5.6e-05 22.8 0.0 0.00017 21.2 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain Rimk_N PF18030.1 AIF83645.1 - 0.00098 19.5 0.0 0.0055 17.1 0.0 2.0 1 1 1 2 2 2 1 RimK PreATP-grasp domain ATP-grasp_6 PF18419.1 AIF83645.1 - 0.017 14.7 0.1 0.034 13.8 0.1 1.5 1 0 0 1 1 1 0 ATP-grasp-like domain ATP-grasp_5 PF13549.6 AIF83645.1 - 0.034 13.6 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain zinc_ribbon_4 PF13717.6 AIF83646.1 - 2.2e-05 24.2 1.9 0.04 13.8 0.1 2.2 1 1 1 2 2 2 2 zinc-ribbon domain zinc_ribbon_5 PF13719.6 AIF83646.1 - 0.00014 21.5 0.1 0.27 11.0 0.0 2.1 2 0 0 2 2 2 2 zinc-ribbon domain zf-RING_7 PF02591.15 AIF83646.1 - 0.00026 21.1 1.8 0.023 14.9 0.1 2.3 2 0 0 2 2 2 1 C4-type zinc ribbon domain zf-HYPF PF07503.12 AIF83646.1 - 0.00027 20.6 1.7 0.0022 17.8 1.7 1.9 1 1 0 1 1 1 1 HypF finger PhnA_Zn_Ribbon PF08274.12 AIF83646.1 - 0.00032 20.6 0.7 0.29 11.1 0.0 2.1 2 0 0 2 2 2 2 PhnA Zinc-Ribbon Prok-RING_1 PF14446.6 AIF83646.1 - 0.00032 20.5 4.4 0.00081 19.3 4.4 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 UPF0547 PF10571.9 AIF83646.1 - 0.00042 20.3 3.5 0.016 15.3 0.5 2.2 2 0 0 2 2 2 1 Uncharacterised protein family UPF0547 zf_UBZ PF18439.1 AIF83646.1 - 0.00076 19.0 0.8 0.6 9.7 0.2 2.2 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger Cys_rich_CPXG PF14255.6 AIF83646.1 - 0.003 17.4 1.1 1.4 8.9 0.2 2.1 2 0 0 2 2 2 2 Cysteine-rich CPXCG Zn-ribbon_8 PF09723.10 AIF83646.1 - 0.0044 17.1 2.4 0.0097 16.0 2.4 1.6 1 1 0 1 1 1 1 Zinc ribbon domain DNA_ligase_ZBD PF03119.16 AIF83646.1 - 0.0049 16.9 1.0 2.7 8.1 0.1 2.3 2 0 0 2 2 2 2 NAD-dependent DNA ligase C4 zinc finger domain ADK_lid PF05191.14 AIF83646.1 - 0.005 16.8 0.4 0.015 15.3 0.0 1.8 2 0 0 2 2 2 1 Adenylate kinase, active site lid YacG PF03884.14 AIF83646.1 - 0.006 16.3 0.9 2.9 7.7 0.0 2.2 2 0 0 2 2 2 2 DNA gyrase inhibitor YacG zf-ribbon_3 PF13248.6 AIF83646.1 - 0.0063 15.9 5.6 0.9 9.0 5.6 2.2 1 1 0 1 1 1 1 zinc-ribbon domain zf-C4_Topoisom PF01396.19 AIF83646.1 - 0.0079 16.0 1.0 1.8 8.4 0.0 2.1 2 0 0 2 2 2 1 Topoisomerase DNA binding C4 zinc finger zf-IS66 PF13005.7 AIF83646.1 - 0.0086 16.4 2.5 0.45 10.9 0.2 2.4 1 1 1 2 2 2 1 zinc-finger binding domain of transposase IS66 TF_Zn_Ribbon PF08271.12 AIF83646.1 - 0.01 15.3 2.0 0.018 14.6 2.1 1.4 1 1 0 1 1 1 0 TFIIB zinc-binding DZR PF12773.7 AIF83646.1 - 0.01 15.8 0.5 0.014 15.4 0.5 1.3 1 1 0 1 1 1 0 Double zinc ribbon zf-TFIIB PF13453.6 AIF83646.1 - 0.01 15.1 2.2 0.034 13.5 2.7 1.6 1 1 1 2 2 2 0 Transcription factor zinc-finger TerY_C PF15616.6 AIF83646.1 - 0.01 15.9 0.3 0.079 13.1 0.3 1.9 1 1 0 1 1 1 0 TerY-C metal binding domain zinc-ribbons_6 PF07191.12 AIF83646.1 - 0.015 15.3 0.8 0.069 13.1 0.8 1.8 1 1 0 1 1 1 0 zinc-ribbons A2L_zn_ribbon PF08792.10 AIF83646.1 - 0.015 15.0 1.8 0.33 10.7 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain zinc_ribbon_2 PF13240.6 AIF83646.1 - 0.015 15.0 1.6 1.7 8.4 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 AIF83646.1 - 0.019 15.0 0.1 0.019 15.0 0.1 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 AIF83646.1 - 0.023 15.1 1.3 0.036 14.5 1.3 1.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar CpXC PF14353.6 AIF83646.1 - 0.036 14.1 1.7 4.2 7.4 0.2 2.1 1 1 1 2 2 2 0 CpXC protein IBR PF01485.21 AIF83646.1 - 0.038 14.2 0.6 0.051 13.8 0.6 1.2 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zinc_ribbon_9 PF14369.6 AIF83646.1 - 0.04 14.2 3.0 0.13 12.5 3.0 1.8 1 1 0 1 1 1 0 zinc-ribbon OrfB_Zn_ribbon PF07282.11 AIF83646.1 - 0.048 13.6 0.1 0.065 13.2 0.1 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-piccolo PF05715.13 AIF83646.1 - 0.067 13.3 0.1 0.1 12.8 0.1 1.3 1 1 0 1 1 1 0 Piccolo Zn-finger DNA_RNApol_7kD PF03604.13 AIF83646.1 - 0.09 12.5 2.8 0.27 10.9 2.8 1.7 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Elf1 PF05129.13 AIF83646.1 - 0.1 12.7 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like PTP2 PF17022.5 AIF83646.1 - 0.11 12.0 0.1 0.11 12.0 0.1 1.0 1 0 0 1 1 1 0 Polar tube protein 2 from Microsporidia TRAF6_Z2 PF18048.1 AIF83646.1 - 0.12 12.5 1.8 4.4 7.5 0.3 2.2 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 Zn_Tnp_IS1595 PF12760.7 AIF83646.1 - 0.13 12.2 2.1 1.6 8.8 0.1 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Rubredoxin PF00301.20 AIF83646.1 - 0.15 12.1 2.3 7.6 6.6 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin Ogr_Delta PF04606.12 AIF83646.1 - 0.16 12.0 2.2 9.6 6.3 0.3 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf-H2C2_2 PF13465.6 AIF83646.1 - 0.17 12.4 0.5 13 6.4 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger double domain Zn_Tnp_IS1 PF03811.13 AIF83646.1 - 0.18 11.6 0.8 12 5.7 0.1 2.2 2 0 0 2 2 2 0 InsA N-terminal domain zf-C2H2_3 PF13878.6 AIF83646.1 - 0.25 11.2 0.7 2.5 8.0 0.0 2.1 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-ACC PF17848.1 AIF83646.1 - 0.27 11.4 3.5 10 6.3 0.2 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain DUF3797 PF12677.7 AIF83646.1 - 0.8 9.6 4.4 3.1 7.7 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) HMGL-like PF00682.19 AIF83647.1 - 4.6e-71 239.5 0.6 5.9e-71 239.1 0.6 1.1 1 0 0 1 1 1 1 HMGL-like Lyase_1 PF00206.20 AIF83648.1 - 5e-56 190.4 0.0 8.2e-56 189.7 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 AIF83648.1 - 6e-13 49.3 0.0 2.3e-12 47.5 0.0 2.1 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal DUF1761 PF08570.10 AIF83649.1 - 0.025 14.8 0.1 0.027 14.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1761) LMWSLP_N PF12211.8 AIF83649.1 - 0.075 12.6 0.1 0.084 12.5 0.1 1.0 1 0 0 1 1 1 0 Low molecular weight S layer protein N terminal FeS_assembly_P PF01883.19 AIF83651.1 - 9.6e-16 57.7 0.0 1.6e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein HMA PF00403.26 AIF83651.1 - 0.044 14.2 0.1 0.33 11.4 0.0 2.1 2 0 0 2 2 2 0 Heavy-metal-associated domain BNR PF02012.20 AIF83653.1 - 3.9e-05 23.0 1.4 13 6.2 0.0 4.9 4 0 0 4 4 4 2 BNR/Asp-box repeat BNR_2 PF13088.6 AIF83653.1 - 0.00092 18.6 0.0 4.8 6.4 0.0 3.4 2 1 1 3 3 3 2 BNR repeat-like domain CyRPA PF18638.1 AIF83653.1 - 0.069 12.3 0.0 28 3.7 0.0 3.2 3 0 0 3 3 3 0 Cysteine-Rich Protective Antigen 6 bladed domain BNR_3 PF13859.6 AIF83653.1 - 0.14 11.4 0.0 0.49 9.6 0.0 1.8 2 0 0 2 2 2 0 BNR repeat-like domain Fer2_3 PF13085.6 AIF83654.1 - 4.7e-29 100.6 0.1 1.3e-28 99.2 0.0 1.7 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.6 AIF83654.1 - 1.2e-11 44.9 1.4 1.2e-11 44.9 1.4 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIF83654.1 - 1.9e-09 37.5 1.4 1.9e-09 37.5 1.4 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 AIF83654.1 - 7.1e-09 36.1 4.1 7.5e-09 36.0 0.8 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 AIF83654.1 - 2.2e-07 31.4 3.0 2.2e-07 31.4 3.0 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 AIF83654.1 - 1.3e-06 28.3 0.1 4e-06 26.7 0.1 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.6 AIF83654.1 - 2.5e-06 27.6 11.8 6.2e-05 23.1 3.8 2.9 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIF83654.1 - 3.2e-06 28.0 1.9 3.2e-06 28.0 1.9 2.2 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain Fer4 PF00037.27 AIF83654.1 - 1.3e-05 24.8 1.0 1.3e-05 24.8 1.0 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_18 PF13746.6 AIF83654.1 - 0.00024 21.3 5.5 0.19 12.0 0.2 2.9 2 1 1 3 3 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIF83654.1 - 0.0035 17.3 3.1 0.0035 17.3 3.1 3.0 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_4 PF12800.7 AIF83654.1 - 0.0047 17.3 1.7 0.0047 17.3 1.7 3.1 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_22 PF17179.4 AIF83654.1 - 0.012 16.5 6.5 0.44 11.4 2.6 2.8 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIF83654.1 - 0.023 14.7 2.7 0.023 14.7 2.7 3.3 3 0 0 3 3 3 0 4Fe-4S binding domain FlhC PF05280.11 AIF83654.1 - 0.081 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhC) Fer2_4 PF13510.6 AIF83654.1 - 0.087 12.9 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Fer4_15 PF13459.6 AIF83654.1 - 0.45 11.3 2.1 3.6 8.4 0.1 2.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_21 PF14697.6 AIF83654.1 - 2.8 8.2 15.2 0.3 11.2 7.7 2.6 2 1 0 2 2 1 0 4Fe-4S dicluster domain Sdh_cyt PF01127.22 AIF83655.1 - 8.4e-08 32.3 6.5 1.1e-07 31.9 6.5 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF1129 PF06570.11 AIF83655.1 - 0.14 11.6 5.7 0.026 14.0 1.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) Fumarate_red_D PF02313.17 AIF83655.1 - 0.25 11.5 7.7 0.35 11.0 7.7 1.2 1 0 0 1 1 1 0 Fumarate reductase subunit D Sdh_cyt PF01127.22 AIF83656.1 - 7.9e-13 48.5 0.2 9.6e-13 48.2 0.2 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Fumarate_red_C PF02300.17 AIF83656.1 - 0.0043 17.1 0.5 0.018 15.1 0.1 1.8 2 0 0 2 2 2 1 Fumarate reductase subunit C Fumarate_red_D PF02313.17 AIF83656.1 - 0.18 11.9 0.1 0.18 11.9 0.1 2.1 2 0 0 2 2 2 0 Fumarate reductase subunit D FAD_binding_2 PF00890.24 AIF83657.1 - 1.3e-95 321.0 0.2 1.7e-95 320.6 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 AIF83657.1 - 1.3e-37 128.6 0.8 2.2e-37 127.9 0.8 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 AIF83657.1 - 0.00077 18.8 0.1 0.0036 16.6 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 AIF83657.1 - 0.004 16.8 2.4 0.52 9.8 1.0 2.3 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_oxidored PF12831.7 AIF83657.1 - 0.039 13.3 2.6 0.038 13.3 1.0 1.8 3 0 0 3 3 3 0 FAD dependent oxidoreductase GIDA PF01134.22 AIF83657.1 - 0.047 12.8 0.4 0.047 12.8 0.4 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 AIF83657.1 - 0.088 11.8 0.6 0.13 11.2 0.6 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 AIF83657.1 - 0.11 11.7 2.5 0.29 10.4 0.6 2.3 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 AIF83657.1 - 0.17 10.5 0.6 0.36 9.5 0.6 1.5 1 0 0 1 1 1 0 HI0933-like protein Ribosomal_L24e PF01246.20 AIF83660.1 - 3.2e-18 65.7 1.4 3.7e-18 65.5 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L24e DUF2116 PF09889.9 AIF83660.1 - 0.0022 17.9 0.9 1.2 9.2 0.2 2.2 2 0 0 2 2 2 2 Uncharacterized protein containing a Zn-ribbon (DUF2116) A2L_zn_ribbon PF08792.10 AIF83660.1 - 0.014 15.1 0.1 2.8 7.8 0.0 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain CDC24_OB3 PF17244.2 AIF83660.1 - 0.05 13.3 0.1 0.056 13.1 0.1 1.1 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 Zn_Tnp_IS1595 PF12760.7 AIF83660.1 - 0.085 12.8 1.1 0.19 11.7 1.1 1.6 1 1 0 1 1 1 0 Transposase zinc-ribbon domain PIN PF01850.21 AIF83664.1 - 4.5e-11 43.3 0.3 5e-11 43.2 0.3 1.0 1 0 0 1 1 1 1 PIN domain VAPB_antitox PF02697.14 AIF83665.1 - 1.4e-17 64.2 0.2 1.9e-17 63.8 0.2 1.1 1 0 0 1 1 1 1 Putative antitoxin TetR_C_24 PF17932.1 AIF83665.1 - 0.057 13.7 0.2 0.098 12.9 0.1 1.4 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain BSD PF03909.17 AIF83665.1 - 0.083 12.9 0.1 0.19 11.8 0.0 1.6 2 0 0 2 2 2 0 BSD domain tRNA-synt_His PF13393.6 AIF83666.1 - 2e-37 129.2 0.0 2e-37 129.2 0.0 1.4 2 0 0 2 2 2 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 AIF83666.1 - 1e-11 44.8 0.1 2.1e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AIF83666.1 - 9.4e-11 42.0 0.0 1.9e-10 41.0 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) TIR_2 PF13676.6 AIF83666.1 - 0.0059 17.2 0.1 0.037 14.7 0.0 2.2 2 0 0 2 2 2 1 TIR domain tRNA-synt_2d PF01409.20 AIF83666.1 - 0.023 14.2 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Archease PF01951.16 AIF83667.1 - 1e-39 135.9 0.8 1.1e-39 135.8 0.8 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) HSP20 PF00011.21 AIF83668.1 - 3.6e-21 75.2 1.9 3.6e-21 75.2 1.9 1.6 2 0 0 2 2 2 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AIF83668.1 - 6.6e-08 32.0 0.0 1e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA pPIWI_RE_REase PF18154.1 AIF83668.1 - 0.033 14.2 0.1 0.079 12.9 0.0 1.7 2 0 0 2 2 2 0 REase associating with pPIWI_RE zinc_ribbon_2 PF13240.6 AIF83669.1 - 4.4e-07 29.4 4.0 8.3e-07 28.5 4.0 1.5 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 AIF83669.1 - 0.00019 21.4 1.3 0.00031 20.7 1.3 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 AIF83669.1 - 0.0003 20.1 3.7 0.0005 19.4 3.7 1.4 1 0 0 1 1 1 1 zinc-ribbon domain UPF0547 PF10571.9 AIF83669.1 - 0.0045 17.0 3.9 0.0088 16.1 3.9 1.5 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 Nudix_N_2 PF14803.6 AIF83669.1 - 0.0056 16.6 2.9 1.5 8.8 0.3 2.4 2 0 0 2 2 2 2 Nudix N-terminal zf_UBZ PF18439.1 AIF83669.1 - 0.071 12.7 1.0 2.8 7.6 0.1 2.3 1 1 1 2 2 2 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 AIF83669.1 - 0.55 11.0 2.6 1 10.1 2.6 1.5 1 0 0 1 1 1 0 zinc-ribbon family zf-NADH-PPase PF09297.11 AIF83669.1 - 5.1 6.8 10.1 4 7.2 0.7 2.4 1 1 1 2 2 2 0 NADH pyrophosphatase zinc ribbon domain SnoaL_2 PF12680.7 AIF83670.1 - 7.1e-10 39.5 0.0 9.3e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 AIF83670.1 - 5e-08 32.8 0.1 6.7e-08 32.4 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase Ferritin PF00210.24 AIF83671.1 - 3.2e-21 75.8 0.0 4.4e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Ferritin-like domain MIP PF00230.20 AIF83672.1 - 1.1e-53 182.3 23.6 1.2e-53 182.1 23.6 1.0 1 0 0 1 1 1 1 Major intrinsic protein EMP70 PF02990.16 AIF83672.1 - 1.2 7.8 6.3 0.39 9.3 3.8 1.4 1 1 0 1 1 1 0 Endomembrane protein 70 HTH_7 PF02796.15 AIF83674.1 - 0.00051 20.1 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase DUF2250 PF10007.9 AIF83674.1 - 0.00082 19.4 0.0 0.0079 16.3 0.0 1.9 1 1 1 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) HTH_IclR PF09339.10 AIF83674.1 - 0.0014 18.4 0.0 0.0024 17.6 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain TBPIP PF07106.13 AIF83674.1 - 0.0022 17.9 1.3 0.019 14.9 0.1 2.1 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain TrmB PF01978.19 AIF83674.1 - 0.0049 16.7 0.0 0.006 16.4 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Mga PF05043.13 AIF83674.1 - 0.015 15.9 0.0 0.03 14.9 0.0 1.5 1 0 0 1 1 1 0 Mga helix-turn-helix domain HTH_Tnp_1_2 PF13022.6 AIF83674.1 - 0.023 14.9 0.5 0.1 12.8 0.4 2.0 1 1 0 1 1 1 0 Helix-turn-helix of insertion element transposase HTH_11 PF08279.12 AIF83674.1 - 0.024 14.6 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 HTH domain HTH_23 PF13384.6 AIF83674.1 - 0.031 14.1 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Rrf2 PF02082.20 AIF83674.1 - 0.058 13.7 0.0 0.24 11.8 0.0 1.8 1 1 1 2 2 2 0 Transcriptional regulator HTH_24 PF13412.6 AIF83674.1 - 0.072 12.7 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding FUR PF01475.19 AIF83674.1 - 0.13 12.5 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Ferric uptake regulator family XPG_I PF00867.18 AIF83675.1 - 5.7e-24 84.3 0.0 1.5e-23 82.9 0.0 1.8 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 AIF83675.1 - 3.6e-18 65.9 0.0 6.5e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 AIF83675.1 - 1.4e-05 25.6 0.0 3.9e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 AIF83675.1 - 0.026 15.1 0.0 0.061 13.9 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain Peptidase_M50 PF02163.22 AIF83675.1 - 0.043 13.1 0.0 0.085 12.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M50 MCM PF00493.23 AIF83677.1 - 4.5e-06 25.9 0.1 0.0071 15.5 0.0 2.6 1 1 1 2 2 2 2 MCM P-loop domain Sigma54_activat PF00158.26 AIF83677.1 - 3e-05 23.8 0.0 0.00011 22.0 0.0 1.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_3 PF07726.11 AIF83677.1 - 0.001 18.9 0.0 0.0064 16.4 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AIF83677.1 - 0.005 16.8 0.1 0.28 11.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 AIF83677.1 - 0.016 15.6 0.1 0.093 13.2 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AIF83677.1 - 0.02 15.3 0.0 0.15 12.4 0.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 AIF83677.1 - 0.027 14.7 0.0 0.62 10.3 0.0 2.3 1 1 1 2 2 2 0 AAA domain DNA_pol3_delta2 PF13177.6 AIF83677.1 - 0.086 12.6 0.1 1 9.1 0.2 2.4 2 1 0 2 2 2 0 DNA polymerase III, delta subunit Glyco_hydro_14 PF01373.17 AIF83678.1 - 0.00011 21.2 0.0 0.00011 21.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 T4_Gp59_N PF08993.10 AIF83678.1 - 0.02 15.3 0.1 0.04 14.3 0.0 1.6 1 1 1 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase Sigma_reg_C PF13791.6 AIF83678.1 - 0.069 13.4 0.1 0.077 13.2 0.1 1.1 1 0 0 1 1 1 0 Sigma factor regulator C-terminal Zn-ribbon_8 PF09723.10 AIF83679.1 - 0.011 15.9 4.8 0.055 13.6 4.8 1.9 1 1 0 1 1 1 0 Zinc ribbon domain TFIIS_C PF01096.18 AIF83679.1 - 0.02 14.7 2.5 0.5 10.3 0.2 2.5 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-NADH-PPase PF09297.11 AIF83679.1 - 0.02 14.5 3.6 0.077 12.7 0.8 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DZR PF12773.7 AIF83679.1 - 0.029 14.4 0.9 0.043 13.9 0.9 1.2 1 0 0 1 1 1 0 Double zinc ribbon TF_Zn_Ribbon PF08271.12 AIF83679.1 - 0.031 13.8 0.6 4.2 7.0 0.1 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding zinc-ribbons_6 PF07191.12 AIF83679.1 - 0.064 13.2 0.0 0.08 12.9 0.0 1.2 1 0 0 1 1 1 0 zinc-ribbons Prok-RING_1 PF14446.6 AIF83679.1 - 0.089 12.7 1.2 0.13 12.3 1.2 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Peptidase_C74 PF12387.8 AIF83679.1 - 0.24 10.8 1.7 0.39 10.2 1.7 1.2 1 0 0 1 1 1 0 Pestivirus NS2 peptidase Rubredoxin_2 PF18073.1 AIF83679.1 - 0.73 9.6 5.5 3.4 7.5 5.5 2.0 1 1 0 1 1 1 0 Rubredoxin metal binding domain zf_UBZ PF18439.1 AIF83679.1 - 0.74 9.5 2.7 4.1 7.1 0.2 2.1 1 1 1 2 2 2 0 Ubiquitin-Binding Zinc Finger Ogr_Delta PF04606.12 AIF83679.1 - 1.8 8.6 4.8 2.8 8.0 0.9 2.2 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Prok-JAB PF14464.6 AIF83681.1 - 1.2e-08 34.7 0.1 9.9e-08 31.8 0.1 2.2 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain PqqD PF05402.12 AIF83682.1 - 2.5e-06 27.7 0.0 3.1e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) Lipase_3 PF01764.25 AIF83683.1 - 0.17 11.7 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF1129 PF06570.11 AIF83684.1 - 0.1 12.1 1.2 0.16 11.4 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) ASH PF15780.5 AIF83685.1 - 0.054 13.7 0.0 0.069 13.4 0.0 1.1 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 AIF83685.1 - 0.13 12.3 0.1 5.8 7.0 0.1 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1573) TMEM190 PF15431.6 AIF83685.1 - 0.14 12.3 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 190 OST3_OST6 PF04756.13 AIF83687.1 - 0.052 12.9 4.0 0.066 12.5 4.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family MerC PF03203.14 AIF83687.1 - 0.52 10.8 6.1 0.88 10.0 6.0 1.5 1 1 0 1 1 1 0 MerC mercury resistance protein Abhydrolase_1 PF00561.20 AIF83688.1 - 1.7e-14 54.1 0.0 4.3e-14 52.8 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold PhaC_N PF07167.13 AIF83688.1 - 8.1e-12 45.1 0.0 1.5e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus Hydrolase_4 PF12146.8 AIF83688.1 - 8.4e-11 41.6 0.0 1.3e-05 24.6 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF3141 PF11339.8 AIF83688.1 - 0.00053 18.5 0.0 0.00099 17.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3141) DLH PF01738.18 AIF83688.1 - 0.002 17.7 0.0 0.021 14.4 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family PHB_depo_C PF06850.11 AIF83688.1 - 0.0023 17.4 0.0 0.017 14.6 0.0 2.1 2 0 0 2 2 2 1 PHB de-polymerase C-terminus PDDEXK_10 PF07788.11 AIF83688.1 - 0.0083 16.0 0.1 0.016 15.1 0.1 1.5 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily FSH1 PF03959.13 AIF83688.1 - 0.071 12.8 0.0 0.43 10.2 0.0 2.2 1 1 0 1 1 1 0 Serine hydrolase (FSH1) PHA_synth_III_E PF09712.10 AIF83689.1 - 1.6e-21 76.8 0.6 2.5e-21 76.1 0.6 1.3 1 1 0 1 1 1 1 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) DUF2730 PF10805.8 AIF83689.1 - 0.0004 20.4 0.6 0.071 13.2 0.1 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF2730) SRP1_TIP1 PF00660.17 AIF83689.1 - 0.0051 16.8 2.7 0.01 15.9 1.1 2.3 2 1 0 2 2 2 1 Seripauperin and TIP1 family Phasin PF05597.11 AIF83689.1 - 0.0059 16.6 0.0 0.0084 16.1 0.0 1.2 1 0 0 1 1 1 1 Poly(hydroxyalcanoate) granule associated protein (phasin) Monooxygenase_B PF04744.12 AIF83690.1 - 0.004 16.1 0.0 0.0075 15.2 0.0 1.4 1 0 0 1 1 1 1 Monooxygenase subunit B protein Gryzun-like PF12742.7 AIF83690.1 - 0.057 13.4 0.0 13 5.8 0.0 2.6 1 1 1 2 2 2 0 Gryzun, putative Golgi trafficking Ifi-6-16 PF06140.13 AIF83691.1 - 6.2 6.8 13.4 7.7 6.5 1.9 2.6 2 0 0 2 2 2 0 Interferon-induced 6-16 family ATP-grasp_5 PF13549.6 AIF83692.1 - 6.7e-63 212.1 0.4 1e-62 211.5 0.4 1.3 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 AIF83692.1 - 1.7e-46 157.4 0.1 6.3e-46 155.6 0.1 2.0 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 AIF83692.1 - 1.3e-20 74.0 0.1 4.1e-20 72.4 0.0 1.9 2 0 0 2 2 2 1 CoA binding domain CoA_binding PF02629.19 AIF83692.1 - 7e-10 39.5 0.2 3.7e-09 37.1 0.2 2.4 1 0 0 1 1 1 1 CoA binding domain ATP-grasp PF02222.22 AIF83692.1 - 0.027 14.0 0.0 0.079 12.5 0.0 1.8 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_2 PF08442.10 AIF83692.1 - 0.043 13.4 0.6 0.094 12.3 0.1 1.8 2 0 0 2 2 2 0 ATP-grasp domain F420_oxidored PF03807.17 AIF83692.1 - 0.054 14.1 0.1 0.22 12.1 0.1 2.2 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent HicA_toxin PF07927.12 AIF83692.1 - 0.17 12.0 0.0 0.45 10.6 0.0 1.7 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, GATase PF00117.28 AIF83693.1 - 5.3e-20 72.0 0.0 7.2e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIF83693.1 - 2.3e-07 30.8 0.3 8.7e-07 28.9 0.3 1.9 1 1 0 1 1 1 1 Peptidase C26 GATase_3 PF07685.14 AIF83693.1 - 0.047 13.3 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 AIF83693.1 - 0.051 13.4 0.0 0.079 12.8 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Toprim_4 PF13662.6 AIF83694.1 - 5.5e-05 23.6 0.0 0.00023 21.6 0.0 1.9 1 1 0 1 1 1 1 Toprim domain Toprim PF01751.22 AIF83694.1 - 9.7e-05 22.5 0.0 0.0027 17.9 0.0 2.2 1 1 0 1 1 1 1 Toprim domain Hydrolase_6 PF13344.6 AIF83694.1 - 0.1 12.7 0.1 0.82 9.8 0.0 2.1 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Toprim_2 PF13155.6 AIF83694.1 - 0.12 12.8 0.0 0.2 12.1 0.0 1.6 1 1 0 1 1 1 0 Toprim-like Toprim_4 PF13662.6 AIF83695.1 - 1.1e-09 38.6 0.5 3.2e-09 37.1 0.5 1.8 1 0 0 1 1 1 1 Toprim domain Toprim_2 PF13155.6 AIF83695.1 - 2.1e-06 28.1 0.0 5.7e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 Toprim-like Toprim PF01751.22 AIF83695.1 - 0.017 15.4 0.4 0.094 12.9 0.4 2.2 1 1 0 1 1 1 0 Toprim domain GRP PF07172.11 AIF83695.1 - 0.098 13.4 12.1 0.18 12.5 12.1 1.4 1 0 0 1 1 1 0 Glycine rich protein family CTP-dep_RFKase PF01982.16 AIF83696.1 - 1.2e-41 141.6 0.0 1.6e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF120 HTH_20 PF12840.7 AIF83696.1 - 0.0012 18.9 0.1 0.002 18.1 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 AIF83696.1 - 0.0018 18.1 0.1 0.0032 17.3 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 AIF83696.1 - 0.002 18.6 0.1 0.0033 17.9 0.1 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain DprA_WH PF17782.1 AIF83696.1 - 0.0029 17.7 0.0 0.0088 16.1 0.0 1.9 3 0 0 3 3 3 1 DprA winged helix domain HTH_34 PF13601.6 AIF83696.1 - 0.0058 16.8 0.0 0.017 15.3 0.0 1.8 2 0 0 2 2 2 1 Winged helix DNA-binding domain MarR PF01047.22 AIF83696.1 - 0.0077 16.1 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 AIF83696.1 - 0.029 14.3 0.1 0.053 13.5 0.1 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_24 PF13412.6 AIF83696.1 - 0.041 13.4 0.0 0.083 12.5 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TrmB PF01978.19 AIF83696.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB AbiEi_4 PF13338.6 AIF83696.1 - 0.14 12.3 0.1 0.37 11.0 0.1 1.7 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin HTH_11 PF08279.12 AIF83696.1 - 0.16 11.9 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 HTH domain CTP_transf_like PF01467.26 AIF83697.1 - 9e-09 35.7 0.0 1.3e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like MazG PF03819.17 AIF83697.1 - 0.0044 17.2 0.1 1.7 8.9 0.0 2.6 2 1 0 2 2 2 2 MazG nucleotide pyrophosphohydrolase domain Methyltransf_31 PF13847.6 AIF83698.1 - 1.2e-29 103.0 0.0 3.6e-29 101.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF83698.1 - 6.1e-19 68.5 0.0 1.1e-18 67.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF83698.1 - 2.9e-17 63.1 0.1 7.9e-17 61.8 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF83698.1 - 1.8e-16 60.5 0.0 3.7e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF83698.1 - 6.3e-16 58.9 0.0 1.1e-15 58.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF83698.1 - 1e-07 31.5 0.0 2e-07 30.6 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 AIF83698.1 - 2.5e-07 30.3 0.0 1.1e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 AIF83698.1 - 3.2e-07 30.0 0.0 5.1e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 AIF83698.1 - 4.8e-07 29.3 0.0 8.1e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 AIF83698.1 - 5.5e-06 25.8 0.0 9.8e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain PCMT PF01135.19 AIF83698.1 - 4e-05 23.5 0.0 6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.12 AIF83698.1 - 0.00014 21.1 0.0 0.00024 20.3 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase PrmA PF06325.13 AIF83698.1 - 0.0003 20.3 0.0 0.00045 19.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 AIF83698.1 - 0.0016 18.0 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.11 AIF83698.1 - 0.0059 15.6 0.0 0.0088 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) DUF938 PF06080.12 AIF83698.1 - 0.0096 15.7 0.0 0.02 14.7 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF938) Methyltransf_32 PF13679.6 AIF83698.1 - 0.017 15.1 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Nre_N PF04894.12 AIF83699.1 - 3e-82 276.5 0.0 4.1e-82 276.1 0.0 1.1 1 0 0 1 1 1 1 Archaeal Nre, N-terminal Nre_C PF04895.12 AIF83699.1 - 1.6e-36 124.6 0.0 2.8e-36 123.8 0.0 1.4 1 0 0 1 1 1 1 Archaeal Nre, C-terminal Psb28 PF03912.14 AIF83700.1 - 0.036 14.3 0.0 0.044 14.1 0.0 1.1 1 0 0 1 1 1 0 Psb28 protein zf-WRNIP1_ubi PF18279.1 AIF83700.1 - 2.6 8.9 5.7 21 6.1 0.4 2.6 1 1 1 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain ProRS-C_1 PF09180.11 AIF83701.1 - 4.6e-23 81.2 0.2 9.9e-23 80.1 0.2 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 AIF83701.1 - 2.2e-20 72.6 0.5 4.3e-20 71.7 0.5 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AIF83701.1 - 9.8e-19 68.0 0.0 1.5e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) TIR_2 PF13676.6 AIF83701.1 - 0.14 12.7 0.2 0.87 10.2 0.2 2.3 3 0 0 3 3 3 0 TIR domain SNARE_assoc PF09335.11 AIF83702.1 - 1.2e-16 61.3 1.5 1.2e-16 61.3 1.5 2.4 2 1 1 3 3 3 1 SNARE associated Golgi protein zinc_ribbon_4 PF13717.6 AIF83704.1 - 0.0027 17.6 1.4 0.39 10.7 0.1 2.2 2 0 0 2 2 2 2 zinc-ribbon domain DUF2387 PF09526.10 AIF83704.1 - 0.0047 17.0 0.6 0.0052 16.9 0.6 1.1 1 0 0 1 1 1 1 Probable metal-binding protein (DUF2387) PADR1 PF08063.12 AIF83704.1 - 0.0085 15.9 1.2 0.011 15.5 1.2 1.2 1 0 0 1 1 1 1 PADR1 (NUC008) domain Zn_Tnp_IS1595 PF12760.7 AIF83704.1 - 0.02 14.9 0.3 0.02 14.9 0.3 1.1 1 0 0 1 1 1 0 Transposase zinc-ribbon domain RNA_POL_M_15KD PF02150.16 AIF83704.1 - 0.036 13.9 1.5 0.16 11.8 1.5 1.9 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit Elf1 PF05129.13 AIF83704.1 - 0.038 14.0 1.1 0.044 13.8 1.1 1.1 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.6 AIF83704.1 - 0.053 13.9 1.1 0.06 13.7 1.1 1.1 1 0 0 1 1 1 0 Restriction alleviation protein Lar Auto_anti-p27 PF06677.12 AIF83704.1 - 0.057 13.6 2.7 0.083 13.1 2.7 1.4 1 1 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) C1_4 PF07975.12 AIF83704.1 - 0.12 12.7 3.3 0.46 10.7 3.4 1.8 1 1 1 2 2 2 0 TFIIH C1-like domain zinc_ribbon_5 PF13719.6 AIF83704.1 - 0.13 12.1 5.6 1 9.2 0.5 2.1 1 1 1 2 2 2 0 zinc-ribbon domain zf-TFIIB PF13453.6 AIF83704.1 - 0.28 10.6 3.0 0.47 9.8 3.0 1.4 1 1 0 1 1 1 0 Transcription factor zinc-finger zf_UBZ PF18439.1 AIF83704.1 - 0.62 9.7 2.7 6.6 6.4 0.2 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-H2C2_2 PF13465.6 AIF83704.1 - 3 8.4 7.6 1.2 9.7 0.6 2.1 1 1 1 2 2 2 0 Zinc-finger double domain SMC_N PF02463.19 AIF83705.1 - 5.7e-59 199.2 12.5 5.2e-58 196.1 12.5 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AIF83705.1 - 1.1e-15 58.0 0.1 8.6e-15 55.1 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AIF83705.1 - 1.7e-13 51.0 3.0 1.1e-05 25.4 1.3 2.9 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AIF83705.1 - 8.1e-13 48.8 14.8 3.5e-08 33.6 2.6 3.9 2 2 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 AIF83705.1 - 4.9e-11 43.5 28.7 4.9e-11 43.5 28.7 6.2 2 2 0 2 2 1 1 AAA domain AAA_29 PF13555.6 AIF83705.1 - 5.3e-07 29.3 0.0 1.3e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain CENP-F_leu_zip PF10473.9 AIF83705.1 - 2.8e-05 24.1 29.6 0.00039 20.5 15.5 7.2 4 3 3 7 7 7 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SHE3 PF17078.5 AIF83705.1 - 4.8e-05 23.2 10.6 4.8e-05 23.2 10.6 5.3 3 2 2 5 5 5 1 SWI5-dependent HO expression protein 3 Spc7 PF08317.11 AIF83705.1 - 0.00095 18.1 89.5 0.013 14.4 7.3 6.3 2 2 3 6 6 6 4 Spc7 kinetochore protein FPP PF05911.11 AIF83705.1 - 0.0011 17.3 11.0 0.0011 17.3 11.0 4.3 2 2 1 4 4 4 2 Filament-like plant protein, long coiled-coil Filament PF00038.21 AIF83705.1 - 0.0044 16.7 20.0 0.0044 16.7 20.0 5.8 2 2 2 6 6 6 2 Intermediate filament protein AAA_13 PF13166.6 AIF83705.1 - 0.0073 15.0 72.0 0.038 12.6 17.7 6.1 3 1 2 6 6 6 3 AAA domain SbcCD_C PF13558.6 AIF83705.1 - 0.0095 16.2 0.2 0.074 13.3 0.0 2.6 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 AIF83705.1 - 0.018 15.6 0.5 0.018 15.6 0.5 5.8 2 2 2 4 4 3 0 ABC transporter Fib_alpha PF08702.10 AIF83705.1 - 0.024 14.8 0.7 0.024 14.8 0.7 6.3 4 2 3 7 7 7 0 Fibrinogen alpha/beta chain family NACHT PF05729.12 AIF83705.1 - 0.065 13.1 0.0 0.27 11.2 0.0 2.1 2 0 0 2 2 1 0 NACHT domain MscS_porin PF12795.7 AIF83705.1 - 0.12 11.9 84.0 0.036 13.6 9.0 5.5 2 2 3 5 5 5 0 Mechanosensitive ion channel porin domain DUF1664 PF07889.12 AIF83705.1 - 0.25 11.4 52.8 0.16 12.0 0.7 7.6 4 2 3 8 8 8 0 Protein of unknown function (DUF1664) DUF4201 PF13870.6 AIF83705.1 - 1.7 8.4 63.6 0.27 11.0 4.0 6.7 3 2 2 6 6 5 0 Domain of unknown function (DUF4201) YojJ PF10372.9 AIF83705.1 - 2.4 8.3 14.8 4.4 7.5 1.8 5.3 5 1 0 5 5 3 0 Bacterial membrane-spanning protein N-terminus DUF948 PF06103.11 AIF83705.1 - 3 8.1 28.6 1.6 9.0 0.1 7.9 6 2 0 9 9 9 0 Bacterial protein of unknown function (DUF948) MtrG PF04210.13 AIF83705.1 - 3.9 7.4 8.9 11 6.0 0.0 4.9 5 1 0 5 5 4 0 Tetrahydromethanopterin S-methyltransferase, subunit G Fzo_mitofusin PF04799.13 AIF83705.1 - 6.8 6.2 50.1 0.28 10.7 4.0 6.7 4 3 2 6 6 6 0 fzo-like conserved region ATG16 PF08614.11 AIF83705.1 - 8 6.6 86.7 0.15 12.3 9.1 6.5 3 2 3 6 6 6 0 Autophagy protein 16 (ATG16) Inos-1-P_synth PF01658.17 AIF83706.1 - 5.9e-26 90.9 0.0 9.4e-26 90.2 0.0 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Acetyltransf_10 PF13673.7 AIF83707.1 - 5.9e-05 23.0 0.0 8.1e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AIF83707.1 - 0.00026 21.4 0.0 0.00045 20.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AIF83707.1 - 0.096 12.7 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein tRNA-synt_1e PF01406.19 AIF83708.1 - 3.6e-70 236.7 0.0 6.7e-70 235.8 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 AIF83708.1 - 1e-14 54.1 0.1 4e-07 29.1 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AIF83708.1 - 8.6e-09 34.2 0.0 1.8e-07 29.8 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.18 AIF83708.1 - 5.5e-07 28.8 0.0 0.0034 16.4 0.1 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (K) DALR_2 PF09190.11 AIF83708.1 - 0.0012 19.3 1.7 0.0046 17.4 0.8 2.4 1 1 1 2 2 2 1 DALR domain tRNA-synt_1c PF00749.21 AIF83708.1 - 0.035 13.0 0.1 0.14 11.1 0.1 1.9 1 1 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain Radical_SAM PF04055.21 AIF83709.1 - 2.3e-15 57.4 0.3 4e-15 56.6 0.3 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 AIF83709.1 - 6.1e-06 26.4 0.2 1.5e-05 25.1 0.2 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 AIF83709.1 - 0.00027 21.2 0.1 0.0012 19.1 0.1 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain SPASM PF13186.6 AIF83709.1 - 0.0066 16.9 1.9 0.019 15.5 1.9 1.8 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain LysE PF01810.18 AIF83710.1 - 3.9e-19 68.9 16.9 4.7e-19 68.6 16.9 1.1 1 0 0 1 1 1 1 LysE type translocator Alba PF01918.21 AIF83711.1 - 1.1e-14 54.0 0.3 1.4e-14 53.6 0.3 1.2 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 AIF83711.1 - 0.018 15.0 0.3 0.031 14.3 0.1 1.5 1 1 1 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P SGL PF08450.12 AIF83713.1 - 1.7e-12 47.5 1.2 0.00039 20.1 0.0 5.1 4 1 1 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 AIF83713.1 - 2.4e-07 30.2 4.7 17 6.1 0.0 6.7 6 0 0 6 6 6 0 Two component regulator propeller SBBP PF06739.11 AIF83713.1 - 0.00059 19.8 4.5 0.39 10.8 0.2 4.2 4 0 0 4 4 4 1 Beta-propeller repeat fn3_5 PF06280.12 AIF83713.1 - 0.00096 19.8 1.4 0.91 10.2 0.0 2.6 1 1 1 2 2 2 2 Fn3-like domain NHL PF01436.21 AIF83713.1 - 0.0056 16.7 0.3 12 6.2 0.0 4.4 5 0 0 5 5 5 1 NHL repeat DUF1735 PF08522.10 AIF83713.1 - 0.016 15.8 0.4 10 6.8 0.0 4.2 3 2 1 4 4 4 0 Domain of unknown function (DUF1735) Wzt_C PF14524.6 AIF83713.1 - 0.017 15.1 0.0 0.043 13.8 0.0 1.6 1 0 0 1 1 1 0 Wzt C-terminal domain Big_7 PF17957.1 AIF83713.1 - 0.034 14.9 0.7 0.034 14.9 0.7 3.2 3 0 0 3 3 3 0 Bacterial Ig domain DUF4527 PF15030.6 AIF83713.1 - 0.038 13.4 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) Glyco_hydro_5_C PF18564.1 AIF83713.1 - 0.096 13.2 0.0 4.9 7.8 0.0 3.3 2 1 1 3 3 2 0 Glycoside hydrolase family 5 C-terminal domain Kelch_2 PF07646.15 AIF83713.1 - 0.13 12.3 1.4 8.1 6.6 0.0 3.2 3 0 0 3 3 3 0 Kelch motif DUF1138 PF06592.13 AIF83713.1 - 1.1 9.4 3.8 9.5 6.4 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1138) EamA PF00892.20 AIF83714.1 - 2.6e-36 124.8 40.5 3.1e-18 66.3 12.6 2.0 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 AIF83714.1 - 3e-05 23.5 18.3 0.00096 18.6 17.7 2.1 1 1 0 1 1 1 1 Triose-phosphate Transporter family DUF3852 PF12963.7 AIF83714.1 - 0.32 11.3 0.1 0.32 11.3 0.1 3.2 3 2 1 4 4 4 0 Protein of unknown function (DUF3852) TMEM234 PF10639.9 AIF83714.1 - 0.56 10.3 8.8 0.41 10.7 0.1 2.7 2 1 1 3 3 3 0 Putative transmembrane family 234 PTH2 PF01981.16 AIF83715.1 - 4.1e-42 143.2 0.1 4.6e-42 143.0 0.1 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 FAD_binding_3 PF01494.19 AIF83716.1 - 1.2e-10 41.2 0.2 2.4e-06 27.0 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 AIF83716.1 - 1.3e-06 28.2 4.3 0.019 14.6 0.1 2.3 1 1 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 AIF83716.1 - 4.7e-06 25.6 1.3 0.0022 16.8 0.5 2.2 2 0 0 2 2 2 2 HI0933-like protein FAD_oxidored PF12831.7 AIF83716.1 - 5e-06 26.1 0.3 7.2e-06 25.6 0.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 AIF83716.1 - 0.00013 20.9 1.9 0.044 12.6 0.0 2.8 2 1 0 2 2 2 2 Tryptophan halogenase Pyr_redox_3 PF13738.6 AIF83716.1 - 0.00062 19.1 0.2 0.16 11.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AIF83716.1 - 0.0047 16.2 1.0 0.01 15.1 0.3 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 AIF83716.1 - 0.0063 15.8 1.4 0.22 10.7 0.8 2.3 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AIF83716.1 - 0.0079 15.3 1.7 0.014 14.5 1.7 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 AIF83716.1 - 0.11 12.7 3.0 0.17 12.1 0.2 2.6 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain DUF1610 PF07754.11 AIF83717.1 - 8.1e-08 32.1 6.4 8.1e-08 32.1 6.4 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF1610) DZR PF12773.7 AIF83717.1 - 0.11 12.6 14.3 0.73 9.9 5.1 2.3 1 1 1 2 2 2 0 Double zinc ribbon zf-ACC PF17848.1 AIF83717.1 - 0.37 10.9 10.0 28 4.9 0.1 4.1 4 0 0 4 4 4 0 Acetyl-coA carboxylase zinc finger domain DUF2321 PF10083.9 AIF83717.1 - 0.57 9.8 4.6 0.89 9.2 4.6 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Zn_ribbon_SprT PF17283.2 AIF83717.1 - 0.62 10.0 13.8 4.3 7.3 0.3 4.0 4 0 0 4 4 4 0 SprT-like zinc ribbon domain Rubredoxin_2 PF18073.1 AIF83717.1 - 1.1 9.0 21.3 1 9.1 8.0 3.7 3 1 0 3 3 3 0 Rubredoxin metal binding domain C1_2 PF03107.16 AIF83717.1 - 2.5 8.5 14.5 3.3 8.1 6.0 2.1 1 1 1 2 2 2 0 C1 domain DUF2752 PF10825.8 AIF83717.1 - 2.6 8.2 8.7 2.4 8.3 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2752) PolC_DP2 PF03833.13 AIF83717.1 - 4.9 4.9 5.2 5 4.9 5.2 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-B_box PF00643.24 AIF83717.1 - 5.1 7.3 12.0 13 6.1 6.9 2.6 1 1 0 2 2 2 0 B-box zinc finger DUF3716 PF12511.8 AIF83717.1 - 5.7 7.1 12.9 24 5.1 12.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3716) EF1_GNE PF00736.19 AIF83718.1 - 6.8e-15 55.0 0.1 7.7e-15 54.8 0.1 1.0 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain PH_3 PF14593.6 AIF83718.1 - 0.11 12.6 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 PH domain AAA PF00004.29 AIF83719.1 - 1.2e-91 304.1 0.0 4.2e-48 163.1 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AIF83719.1 - 7.6e-32 108.9 0.4 2.1e-15 56.2 0.0 2.8 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 AIF83719.1 - 1.3e-28 99.0 0.8 3.6e-28 97.6 0.2 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 AIF83719.1 - 5.5e-14 52.6 0.0 2.9e-08 34.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AIF83719.1 - 1.9e-13 50.5 0.0 1.3e-07 31.4 0.0 3.0 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AIF83719.1 - 4.7e-12 46.6 0.9 0.00098 19.5 0.1 4.7 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 AIF83719.1 - 2.2e-11 43.9 0.1 3.9e-05 23.7 0.0 4.2 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 AIF83719.1 - 2.4e-10 40.5 0.0 1.4e-05 25.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 AIF83719.1 - 4.2e-10 40.0 0.5 0.029 14.6 0.1 4.4 2 2 1 3 3 3 2 AAA domain AAA_33 PF13671.6 AIF83719.1 - 1.4e-09 38.3 0.0 8.9e-05 22.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 AIF83719.1 - 3.5e-08 33.0 0.2 0.0061 15.8 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain IstB_IS21 PF01695.17 AIF83719.1 - 1.1e-07 31.7 0.0 0.01 15.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_25 PF13481.6 AIF83719.1 - 1.2e-07 31.5 0.2 1.2 8.7 0.0 4.3 4 0 0 4 4 4 2 AAA domain RNA_helicase PF00910.22 AIF83719.1 - 1.8e-07 31.5 0.0 0.014 15.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 AIF83719.1 - 4.5e-07 30.3 0.0 0.0081 16.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 AIF83719.1 - 5.2e-07 30.3 0.0 0.011 16.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 AIF83719.1 - 1.1e-06 28.5 0.2 0.1 12.3 0.0 3.5 3 1 0 3 3 2 2 Sigma-54 interaction domain AAA_24 PF13479.6 AIF83719.1 - 1.2e-06 28.4 0.0 0.024 14.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 AIF83719.1 - 1.3e-06 28.1 0.0 0.058 12.9 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 AIF83719.1 - 1.7e-06 27.6 0.7 0.0078 15.6 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 AIF83719.1 - 1.8e-06 28.5 0.0 0.022 15.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter CDC48_2 PF02933.17 AIF83719.1 - 2e-06 27.5 0.1 4.8e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 ATPase PF06745.13 AIF83719.1 - 9.5e-06 25.1 0.2 0.33 10.3 0.0 3.4 2 1 1 3 3 3 2 KaiC PhoH PF02562.16 AIF83719.1 - 2.3e-05 23.9 2.6 0.22 10.9 0.0 3.3 2 1 1 3 3 3 2 PhoH-like protein ATPase_2 PF01637.18 AIF83719.1 - 2.6e-05 24.3 0.1 0.019 14.9 0.0 3.2 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea DUF2075 PF09848.9 AIF83719.1 - 2.8e-05 23.5 0.0 0.014 14.7 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Sigma54_activ_2 PF14532.6 AIF83719.1 - 8.7e-05 22.7 0.0 0.2 11.8 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain Parvo_NS1 PF01057.17 AIF83719.1 - 0.00016 20.9 0.2 0.15 11.1 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 ResIII PF04851.15 AIF83719.1 - 0.00024 21.1 0.0 0.31 11.0 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AIF83719.1 - 0.00038 20.3 0.8 0.36 10.6 0.0 3.9 2 2 1 4 4 4 1 DEAD/DEAH box helicase TsaE PF02367.17 AIF83719.1 - 0.00044 20.2 0.0 0.68 9.9 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 AIF83719.1 - 0.00058 19.1 0.0 0.55 9.4 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) ATP-synt_ab PF00006.25 AIF83719.1 - 0.00067 19.4 0.1 0.24 11.0 0.0 2.5 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Rad17 PF03215.15 AIF83719.1 - 0.00091 19.2 0.5 2.3 8.1 0.0 3.6 2 2 1 3 3 3 1 Rad17 P-loop domain Bac_DnaA PF00308.18 AIF83719.1 - 0.0012 18.8 0.0 0.35 10.7 0.0 3.1 3 1 0 3 3 2 1 Bacterial dnaA protein Vps4_C PF09336.10 AIF83719.1 - 0.0016 18.4 0.0 0.17 11.9 0.0 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Cytidylate_kin PF02224.18 AIF83719.1 - 0.0018 18.0 0.2 1.6 8.5 0.0 2.9 3 0 0 3 3 2 1 Cytidylate kinase AAA_6 PF12774.7 AIF83719.1 - 0.0028 16.7 0.0 1.7 7.5 0.0 2.8 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region Zeta_toxin PF06414.12 AIF83719.1 - 0.0045 16.3 0.1 3.8 6.7 0.1 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 AIF83719.1 - 0.0056 16.4 0.1 3.1 7.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 AIF83719.1 - 0.006 16.4 0.8 1.3 8.8 0.1 2.9 2 1 0 3 3 3 1 AAA domain NACHT PF05729.12 AIF83719.1 - 0.006 16.5 0.3 10 6.0 0.0 3.5 3 0 0 3 3 3 0 NACHT domain AAA_3 PF07726.11 AIF83719.1 - 0.0072 16.2 0.0 0.63 9.9 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 AIF83719.1 - 0.0087 16.5 0.1 3.2 8.2 0.0 3.3 3 1 0 3 3 3 1 AAA domain TniB PF05621.11 AIF83719.1 - 0.014 14.8 0.0 8.3 5.8 0.0 3.4 4 0 0 4 4 4 0 Bacterial TniB protein Guanylate_kin PF00625.21 AIF83719.1 - 0.016 14.9 0.4 49 3.5 0.0 4.0 2 2 2 4 4 4 0 Guanylate kinase IPT PF01745.16 AIF83719.1 - 0.017 14.6 0.2 1.1 8.6 0.1 2.4 2 0 0 2 2 2 0 Isopentenyl transferase T2SSE PF00437.20 AIF83719.1 - 0.027 13.5 0.0 4.7 6.2 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.6 AIF83719.1 - 0.038 13.7 0.3 2.7 7.8 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_21 PF13304.6 AIF83719.1 - 0.044 13.6 0.4 5.6 6.7 0.1 2.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_19 PF13245.6 AIF83719.1 - 0.061 13.7 1.1 7.5 6.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain SRPRB PF09439.10 AIF83719.1 - 0.077 12.4 0.0 22 4.4 0.0 2.9 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit SKI PF01202.22 AIF83719.1 - 0.083 13.0 0.2 19 5.4 0.0 3.1 3 0 0 3 3 3 0 Shikimate kinase Disulph_isomer PF06491.11 AIF83719.1 - 0.12 12.5 0.0 26 4.9 0.0 2.7 2 0 0 2 2 2 0 Disulphide isomerase NB-ARC PF00931.22 AIF83719.1 - 0.19 10.9 0.1 10 5.2 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_23 PF13476.6 AIF83719.1 - 0.24 11.9 0.6 17 5.9 0.2 2.7 2 0 0 2 2 2 0 AAA domain SCAB_CC PF16712.5 AIF83720.1 - 0.024 14.5 0.1 0.03 14.2 0.1 1.1 1 0 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein DUF1456 PF07308.13 AIF83721.1 - 0.0041 17.4 0.2 0.005 17.1 0.2 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1456) YjcQ PF09639.10 AIF83721.1 - 0.068 13.4 0.1 0.076 13.2 0.1 1.1 1 0 0 1 1 1 0 YjcQ protein UbiA PF01040.18 AIF83722.1 - 8.2e-53 179.3 25.5 1.1e-52 178.8 25.5 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family CrgA PF06781.12 AIF83722.1 - 1.2 9.2 6.0 0.57 10.3 1.8 2.7 3 0 0 3 3 3 0 Cell division protein CrgA Copper-bind PF00127.20 AIF83724.1 - 1.5e-16 60.7 2.7 9.5e-08 32.4 0.1 2.8 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF83724.1 - 3.3e-15 56.1 0.0 1.8e-08 34.4 0.0 2.5 2 1 0 2 2 2 2 Cupredoxin-like domain DUF2061 PF09834.9 AIF83724.1 - 0.41 11.2 2.8 2 9.0 2.8 2.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2061) Prok-JAB PF14464.6 AIF83725.1 - 3e-15 56.0 0.0 3.6e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain JAB PF01398.21 AIF83725.1 - 0.007 16.3 0.0 0.01 15.8 0.0 1.3 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease tRNA-synt_2 PF00152.20 AIF83726.1 - 6.6e-84 281.7 0.0 9.6e-84 281.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AIF83726.1 - 5.9e-11 42.2 0.6 1.1e-10 41.4 0.6 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AIF83726.1 - 0.00047 19.7 0.2 0.066 12.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) KH_5 PF13184.6 AIF83727.1 - 0.00089 19.3 0.0 0.0032 17.5 0.0 1.9 2 0 0 2 2 2 1 NusA-like KH domain 4_1_CTD PF05902.13 AIF83729.1 - 0.13 12.4 0.1 0.19 11.8 0.1 1.3 1 0 0 1 1 1 0 4.1 protein C-terminal domain (CTD) TIG PF01833.24 AIF83731.1 - 0.00012 22.0 0.8 0.00021 21.3 0.8 1.5 1 1 0 1 1 1 1 IPT/TIG domain Big_7 PF17957.1 AIF83731.1 - 0.0092 16.7 1.3 0.013 16.3 0.2 1.8 2 0 0 2 2 2 1 Bacterial Ig domain MG2 PF01835.19 AIF83731.1 - 0.016 15.6 0.0 0.029 14.8 0.0 1.4 1 1 0 1 1 1 0 MG2 domain Big_3_5 PF16640.5 AIF83731.1 - 0.25 11.5 6.1 1.1 9.4 6.1 2.1 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 3) Phasin_2 PF09361.10 AIF83732.1 - 0.0011 19.2 0.4 0.0011 19.2 0.4 2.8 1 1 2 3 3 3 1 Phasin protein Msap1 PF17077.5 AIF83732.1 - 0.023 13.9 1.4 0.026 13.7 1.4 1.2 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 UpxZ PF06603.11 AIF83732.1 - 0.035 14.4 0.4 0.12 12.7 0.0 1.9 2 0 0 2 2 2 0 UpxZ family of transcription anti-terminator antagonists DUF648 PF04890.13 AIF83732.1 - 0.037 13.8 0.5 0.046 13.5 0.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF648) Mitofilin PF09731.9 AIF83732.1 - 0.075 11.9 8.2 0.088 11.6 8.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF1043 PF06295.12 AIF83732.1 - 0.12 12.3 6.6 0.35 10.9 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) Prominin PF05478.11 AIF83732.1 - 0.15 9.9 6.8 0.14 10.0 1.9 1.9 1 1 0 2 2 2 0 Prominin DUF1995 PF09353.10 AIF83732.1 - 0.29 11.2 4.9 1.6 8.7 4.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1995) DUF4854 PF16146.5 AIF83732.1 - 0.39 11.1 8.7 8.4 6.8 0.2 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4854) DUF4200 PF13863.6 AIF83732.1 - 0.61 10.5 9.6 0.19 12.2 4.7 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) DUF1664 PF07889.12 AIF83732.1 - 0.83 9.7 5.3 0.76 9.8 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Med9 PF07544.13 AIF83732.1 - 0.93 9.6 5.4 0.39 10.8 2.4 2.0 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Sec20 PF03908.13 AIF83732.1 - 1 9.3 6.0 1 9.3 0.2 2.5 2 1 1 3 3 3 0 Sec20 YtxH PF12732.7 AIF83732.1 - 1.4 9.5 7.0 43 4.7 7.0 2.7 1 1 0 1 1 1 0 YtxH-like protein UPF0242 PF06785.11 AIF83732.1 - 1.4 9.0 7.1 0.65 10.1 5.1 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF5427 PF10310.9 AIF83732.1 - 2.4 7.0 12.3 3 6.7 12.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Fib_alpha PF08702.10 AIF83732.1 - 8.4 6.6 8.9 2.4 8.3 5.3 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF883 PF05957.13 AIF83732.1 - 8.6 7.0 9.8 3.3 8.4 1.1 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF2171 PF09939.9 AIF83734.1 - 0.00018 21.7 0.1 0.021 15.1 0.0 2.7 2 1 1 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2171) Tenui_PVC2 PF06656.11 AIF83734.1 - 0.086 10.7 0.0 0.099 10.5 0.0 1.1 1 0 0 1 1 1 0 Tenuivirus PVC2 protein ABC_tran PF00005.27 AIF83735.1 - 2.9e-24 86.1 0.0 4.4e-24 85.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 AIF83735.1 - 1.7e-21 76.5 0.2 3.2e-21 75.6 0.2 1.5 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 AIF83735.1 - 1.5e-08 34.9 0.6 3.9e-06 26.9 0.3 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIF83735.1 - 0.003 17.0 0.6 0.021 14.3 0.1 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 AIF83735.1 - 0.0094 16.4 0.1 0.019 15.4 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain ATP-synt_ab PF00006.25 AIF83735.1 - 0.018 14.7 0.1 0.53 9.9 0.1 2.1 1 1 1 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ABC_ATPase PF09818.9 AIF83735.1 - 0.024 13.4 0.8 1.2 7.8 0.2 2.5 2 1 0 2 2 2 0 Predicted ATPase of the ABC class AAA_25 PF13481.6 AIF83735.1 - 0.027 14.0 0.1 4.4 6.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 AIF83735.1 - 0.043 13.2 0.2 2.3 7.6 0.1 2.3 2 0 0 2 2 2 0 Bacterial TniB protein MMR_HSR1 PF01926.23 AIF83735.1 - 0.16 12.1 0.0 0.33 11.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 AIF83735.1 - 0.21 12.1 0.1 1 9.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AIF83735.1 - 0.27 11.5 1.3 6.6 7.0 1.3 2.2 1 1 0 1 1 1 0 AAA domain Helicase_C_2 PF13307.6 AIF83736.1 - 8.6e-20 71.6 0.1 2.4e-19 70.1 0.0 1.7 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.15 AIF83736.1 - 5.3e-06 26.5 3.3 2.3e-05 24.5 0.1 3.2 2 2 1 3 3 3 1 Type III restriction enzyme, res subunit DEAD_2 PF06733.15 AIF83736.1 - 6.1e-06 26.0 0.0 1.1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 AIF83736.1 - 2.7e-05 24.0 0.0 0.19 11.5 0.0 2.8 2 0 0 2 2 2 2 DEAD/DEAH box helicase AAA_16 PF13191.6 AIF83736.1 - 0.16 12.4 0.0 1.2 9.5 0.0 2.4 2 1 0 3 3 3 0 AAA ATPase domain DUF998 PF06197.13 AIF83737.1 - 0.007 16.0 9.5 0.007 16.0 9.5 3.3 2 2 2 4 4 4 1 Protein of unknown function (DUF998) Gram_pos_anchor PF00746.21 AIF83737.1 - 4.4 7.3 4.9 33 4.5 0.3 3.4 3 0 0 3 3 3 0 LPXTG cell wall anchor motif IMS PF00817.20 AIF83738.1 - 1.7e-41 141.7 0.9 6.9e-41 139.7 0.2 2.0 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 AIF83738.1 - 8.2e-08 33.0 0.5 1.4e-07 32.2 0.5 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 AIF83738.1 - 2e-06 27.8 0.0 5.2e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif HHH_5 PF14520.6 AIF83738.1 - 1.5e-05 25.5 0.3 7.9e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix domain Cdd1 PF11731.8 AIF83738.1 - 0.00075 19.7 0.1 0.0088 16.3 0.0 2.7 3 0 0 3 3 3 1 Pathogenicity locus HHH PF00633.23 AIF83738.1 - 0.022 14.6 0.1 0.19 11.7 0.0 2.6 1 1 1 2 2 2 0 Helix-hairpin-helix motif CorA PF01544.18 AIF83738.1 - 0.082 12.2 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein HHH_8 PF14716.6 AIF83738.1 - 0.097 13.1 0.1 1.5 9.2 0.0 2.9 3 0 0 3 3 3 0 Helix-hairpin-helix domain BAF PF02961.14 AIF83738.1 - 0.16 12.4 0.2 0.6 10.6 0.0 2.0 3 0 0 3 3 3 0 Barrier to autointegration factor PGK PF00162.19 AIF83739.1 - 2.1e-135 451.5 0.0 2.6e-135 451.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF929 PF06053.11 AIF83740.1 - 1.2e-23 83.7 0.0 2.6e-23 82.6 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF929) Ribosomal_L16 PF00252.18 AIF83741.1 - 1.8e-29 102.4 0.2 2.4e-29 102.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e tRNA_int_endo PF01974.17 AIF83742.1 - 2.6e-19 69.1 1.4 2.7e-19 69.0 0.3 1.5 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 AIF83742.1 - 9.8e-08 31.6 0.2 1.8e-07 30.7 0.2 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain tRNA_int_end_N2 PF12928.7 AIF83742.1 - 0.076 13.2 0.1 0.3 11.3 0.1 1.9 2 0 0 2 2 2 0 tRNA-splicing endonuclease subunit sen54 N-term CreA PF05981.12 AIF83743.1 - 0.026 14.5 0.1 0.027 14.4 0.1 1.0 1 0 0 1 1 1 0 CreA protein FtsQ PF03799.15 AIF83744.1 - 0.026 15.3 0.0 0.031 15.1 0.0 1.2 1 0 0 1 1 1 0 Cell division protein FtsQ Trp_syntA PF00290.20 AIF83744.1 - 0.034 13.0 0.0 0.043 12.6 0.0 1.1 1 0 0 1 1 1 0 Tryptophan synthase alpha chain Robl_LC7 PF03259.17 AIF83744.1 - 0.099 12.4 0.0 1.5 8.7 0.0 2.2 1 1 0 1 1 1 0 Roadblock/LC7 domain CxC5 PF18718.1 AIF83745.1 - 0.054 13.6 3.2 0.061 13.4 3.2 1.3 1 1 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases Opy2 PF09463.10 AIF83745.1 - 0.1 12.9 2.4 0.1 12.9 2.4 1.8 2 0 0 2 2 2 0 Opy2 protein DZR PF12773.7 AIF83745.1 - 0.12 12.4 8.4 2.4 8.3 8.4 2.2 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 AIF83747.1 - 0.00047 20.0 1.2 0.00067 19.5 1.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF2719 PF10891.8 AIF83747.1 - 0.018 15.0 2.7 0.027 14.4 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2719) DUF3797 PF12677.7 AIF83747.1 - 0.3 11.0 2.5 3.6 7.5 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3797) TRAM PF01938.20 AIF83749.1 - 2.9e-13 49.6 1.6 4e-13 49.1 1.6 1.2 1 0 0 1 1 1 1 TRAM domain DUF2464 PF10240.9 AIF83749.1 - 0.075 12.6 0.1 0.09 12.3 0.1 1.1 1 0 0 1 1 1 0 Multivesicular body subunit 12 zf-C2H2_4 PF13894.6 AIF83750.1 - 0.0075 17.0 0.3 0.0099 16.6 0.3 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AIF83750.1 - 0.0081 16.1 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF83750.1 - 0.036 14.5 0.5 0.046 14.2 0.5 1.2 1 0 0 1 1 1 0 Zinc finger, C2H2 type CBS PF00571.28 AIF83751.1 - 5.2e-18 65.2 1.7 2.3e-10 40.8 0.2 2.1 2 0 0 2 2 2 2 CBS domain zinc_ribbon_2 PF13240.6 AIF83755.1 - 2e-05 24.1 5.2 2e-05 24.1 5.2 2.0 2 0 0 2 2 2 1 zinc-ribbon domain DZR PF12773.7 AIF83755.1 - 0.00038 20.4 3.7 0.001 19.0 3.7 1.7 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 AIF83755.1 - 0.001 18.4 3.3 0.001 18.4 3.3 2.2 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 AIF83755.1 - 0.029 15.1 0.8 0.066 14.0 0.8 1.6 1 0 0 1 1 1 0 zinc-ribbon family zf-C6H2 PF15801.5 AIF83755.1 - 0.24 11.7 2.2 0.48 10.8 2.2 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding MMR_HSR1_Xtn PF16897.5 AIF83756.1 - 3.5e-27 94.5 0.4 6.9e-27 93.6 0.4 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 AIF83756.1 - 5.3e-22 78.0 0.0 1.2e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 AIF83756.1 - 2.7e-21 75.4 0.0 6e-21 74.2 0.0 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 AIF83756.1 - 1.3e-14 54.0 0.2 1.2e-12 47.6 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AIF83756.1 - 9e-07 28.9 0.4 0.011 15.7 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 AIF83756.1 - 0.00013 21.5 0.3 0.045 13.2 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Ras PF00071.22 AIF83756.1 - 0.0009 18.9 0.1 0.28 10.8 0.0 2.4 2 0 0 2 2 2 2 Ras family AIG1 PF04548.16 AIF83756.1 - 0.0011 18.4 0.1 0.0039 16.5 0.0 2.0 2 0 0 2 2 2 1 AIG1 family SRPRB PF09439.10 AIF83756.1 - 0.0016 17.9 0.0 0.0034 16.8 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit cobW PF02492.19 AIF83756.1 - 0.004 16.8 0.2 1.1 8.9 0.0 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 AIF83756.1 - 0.0063 16.6 0.1 0.3 11.1 0.1 2.6 2 0 0 2 2 2 1 Dynamin family AAA_28 PF13521.6 AIF83756.1 - 0.0084 16.4 0.1 0.018 15.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 AIF83756.1 - 0.014 15.6 0.0 0.04 14.1 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 AIF83756.1 - 0.045 14.1 0.1 0.094 13.1 0.0 1.6 2 0 0 2 2 1 0 AAA ATPase domain MCM PF00493.23 AIF83756.1 - 0.062 12.4 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_22 PF13401.6 AIF83756.1 - 0.064 13.5 0.0 0.16 12.3 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.6 AIF83756.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cupredoxin_1 PF13473.6 AIF83757.1 - 1.4e-08 34.8 0.0 1.6e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain Peptidase_C25_C PF03785.14 AIF83757.1 - 0.017 15.0 0.3 0.031 14.1 0.0 1.5 2 0 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain Copper-bind PF00127.20 AIF83757.1 - 0.024 15.1 0.3 0.046 14.2 0.3 1.6 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family TRAM PF01938.20 AIF83758.1 - 1.6e-12 47.2 0.9 2.1e-12 46.9 0.9 1.2 1 0 0 1 1 1 1 TRAM domain DUF108 PF01958.18 AIF83759.1 - 2.4e-36 124.0 1.0 4.9e-36 123.0 0.6 1.7 2 0 0 2 2 2 1 Domain of unknown function DUF108 NAD_binding_3 PF03447.16 AIF83759.1 - 1.4e-21 77.4 0.3 2.4e-21 76.5 0.3 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 AIF83759.1 - 4.6e-06 27.5 0.1 1.1e-05 26.2 0.1 1.7 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding PF02629.19 AIF83759.1 - 0.00039 21.1 0.3 0.00097 19.8 0.3 1.6 1 0 0 1 1 1 1 CoA binding domain NAD_binding_2 PF03446.15 AIF83759.1 - 0.012 15.8 0.1 0.02 15.0 0.1 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 AIF83759.1 - 0.019 14.3 0.1 0.031 13.6 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 AIF83759.1 - 0.022 15.3 0.5 0.048 14.3 0.5 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 AIF83759.1 - 0.2 11.5 3.8 1.9 8.3 3.9 2.3 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ribosomal_S30 PF04758.14 AIF83760.1 - 3.8e-11 43.0 5.5 4.5e-11 42.8 5.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S30 NadA PF02445.16 AIF83763.1 - 7.1e-117 389.8 6.0 8.1e-117 389.6 6.0 1.0 1 0 0 1 1 1 1 Quinolinate synthetase A protein Ribosomal_S8 PF00410.19 AIF83763.1 - 0.041 13.8 0.2 0.16 12.0 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein S8 QRPTase_C PF01729.19 AIF83764.1 - 3e-49 167.1 0.4 4.1e-49 166.6 0.4 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 AIF83764.1 - 4.1e-27 94.1 0.4 7.7e-27 93.2 0.4 1.5 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain Ribul_P_3_epim PF00834.19 AIF83764.1 - 0.015 14.7 0.1 0.037 13.4 0.0 1.6 1 1 0 1 1 1 0 Ribulose-phosphate 3 epimerase family PT-HINT PF07591.11 AIF83764.1 - 0.051 13.8 0.1 0.099 12.9 0.1 1.4 1 0 0 1 1 1 0 Pretoxin HINT domain Spt4 PF06093.13 AIF83765.1 - 1.2e-12 47.7 0.1 1.5e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger RecR PF02132.15 AIF83765.1 - 0.00036 20.0 0.8 0.00045 19.7 0.8 1.2 1 0 0 1 1 1 1 RecR protein zf-FPG_IleRS PF06827.14 AIF83765.1 - 0.036 13.9 1.7 1.3 8.9 0.1 2.2 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS TF_Zn_Ribbon PF08271.12 AIF83765.1 - 0.05 13.1 0.5 0.11 12.1 0.0 1.7 2 0 0 2 2 2 0 TFIIB zinc-binding TackOD1 PF18551.1 AIF83765.1 - 0.069 12.8 0.6 0.084 12.5 0.6 1.1 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 zf-RRN7 PF11781.8 AIF83765.1 - 0.12 12.0 2.0 0.25 11.1 0.1 2.0 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zn-ribbon_14 PF16503.5 AIF83765.1 - 0.2 11.2 3.6 0.29 10.7 3.6 1.3 1 0 0 1 1 1 0 Zinc-ribbon SHS2_Rpb7-N PF03876.17 AIF83766.1 - 6e-18 65.0 0.0 5.4e-17 61.9 0.0 2.1 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 AIF83766.1 - 6.7e-14 52.0 0.1 1.7e-13 50.7 0.1 1.7 1 1 0 1 1 1 1 S1 RNA binding domain S1_2 PF13509.6 AIF83766.1 - 0.0037 17.3 0.0 0.011 15.8 0.0 1.8 1 1 1 2 2 2 1 S1 domain ParA PF10609.9 AIF83767.1 - 5.3e-101 337.2 0.3 6.6e-101 336.9 0.3 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase FeS_assembly_P PF01883.19 AIF83767.1 - 1.2e-20 73.5 0.1 3.5e-20 72.0 0.1 1.8 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein CbiA PF01656.23 AIF83767.1 - 1.1e-14 54.6 0.0 3.9e-14 52.8 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 AIF83767.1 - 1.2e-11 44.8 3.5 7.4e-10 39.0 1.8 2.3 1 1 1 2 2 2 1 AAA domain MipZ PF09140.11 AIF83767.1 - 1.9e-06 27.4 0.0 3.5e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 AIF83767.1 - 3.1e-06 26.8 0.1 0.00039 19.9 0.0 2.3 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.15 AIF83767.1 - 5.9e-06 25.7 4.3 7.1e-06 25.4 1.3 2.4 2 1 1 3 3 3 1 Anion-transporting ATPase VirC1 PF07015.11 AIF83767.1 - 0.00022 20.6 0.1 0.00039 19.8 0.1 1.3 1 0 0 1 1 1 1 VirC1 protein AAA_25 PF13481.6 AIF83767.1 - 0.0006 19.4 0.2 0.0011 18.6 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_26 PF13500.6 AIF83767.1 - 0.0014 18.5 2.5 0.49 10.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.22 AIF83767.1 - 0.012 15.3 0.2 0.024 14.3 0.2 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 AIF83767.1 - 0.032 13.7 0.2 0.2 11.1 0.3 1.9 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 AIF83767.1 - 0.059 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase CLP1_P PF16575.5 AIF83767.1 - 0.066 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF359 PF04019.12 AIF83768.1 - 4.3e-36 123.3 0.0 6.6e-36 122.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF359) HEM4 PF02602.15 AIF83768.1 - 0.0028 17.1 0.1 0.0044 16.4 0.1 1.4 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD DUF2318 PF10080.9 AIF83769.1 - 0.087 12.9 6.5 0.97 9.6 6.1 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) DnaJ_CXXCXGXG PF00684.19 AIF83771.1 - 0.00049 20.4 9.3 0.0011 19.2 9.2 1.7 1 1 0 1 1 1 1 DnaJ central domain YacG PF03884.14 AIF83771.1 - 0.016 14.9 9.7 0.12 12.1 0.6 2.3 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG zf-nanos PF05741.13 AIF83771.1 - 0.11 12.7 10.8 0.38 11.0 6.7 2.6 2 1 1 3 3 3 0 Nanos RNA binding domain Zn_Tnp_IS1595 PF12760.7 AIF83771.1 - 0.21 11.6 13.6 4.5 7.3 4.1 3.0 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 AIF83771.1 - 0.21 11.0 13.8 0.93 9.0 3.7 2.5 2 1 0 2 2 2 0 zinc-ribbon domain DUF5351 PF17302.2 AIF83771.1 - 0.43 10.8 9.0 3.5 7.9 0.1 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5351) Lar_restr_allev PF14354.6 AIF83771.1 - 0.71 10.3 17.5 4.6 7.7 0.2 3.1 1 1 1 3 3 3 0 Restriction alleviation protein Lar Anti-TRAP PF15777.5 AIF83771.1 - 1.1 9.3 15.9 0.67 10.0 0.4 3.0 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf_CopZ PF18423.1 AIF83771.1 - 1.8 8.6 12.2 11 6.1 0.1 3.2 3 0 0 3 3 3 0 Zinc binding domain Rad50_zn_hook PF04423.14 AIF83771.1 - 2.5 8.0 6.9 21 5.1 0.1 3.0 3 0 0 3 3 3 0 Rad50 zinc hook motif Prok-RING_4 PF14447.6 AIF83771.1 - 4.5 7.2 18.3 8.4 6.3 0.8 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Auto_anti-p27 PF06677.12 AIF83771.1 - 5.7 7.2 13.0 0.38 10.9 1.8 3.0 2 2 1 3 3 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-TFIIB PF13453.6 AIF83771.1 - 8.6 5.8 14.6 0.69 9.3 1.3 3.3 3 1 0 3 3 3 0 Transcription factor zinc-finger FAD-oxidase_C PF02913.19 AIF83772.1 - 1.8e-51 175.2 0.1 2.3e-51 174.8 0.1 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 AIF83772.1 - 2.5e-33 114.8 0.0 5.6e-33 113.6 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Methyltransf_25 PF13649.6 AIF83773.1 - 4.3e-16 59.4 0.0 7.4e-16 58.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF83773.1 - 6.2e-15 55.6 0.0 1e-14 54.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF83773.1 - 6.5e-15 55.3 0.0 9.3e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF83773.1 - 1.4e-14 54.1 0.0 2e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF83773.1 - 8e-14 52.2 0.0 1.4e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 AIF83773.1 - 2e-10 40.3 0.0 2.9e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Ubie_methyltran PF01209.18 AIF83773.1 - 1.4e-09 37.7 0.0 1.5e-08 34.3 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 AIF83773.1 - 1.2e-05 25.0 0.0 1.7e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.11 AIF83773.1 - 8e-05 21.7 0.0 0.00012 21.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) NodS PF05401.11 AIF83773.1 - 0.00011 21.9 0.0 0.00017 21.3 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_4 PF02390.17 AIF83773.1 - 0.00011 21.7 0.0 0.00057 19.4 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 AIF83773.1 - 0.00016 21.2 0.0 0.00043 19.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Dimerisation2 PF16864.5 AIF83773.1 - 0.00028 20.8 0.0 0.00055 19.9 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain CMAS PF02353.20 AIF83773.1 - 0.035 13.4 0.0 0.048 12.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 AIF83773.1 - 0.048 13.8 0.0 0.079 13.1 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 AIF83773.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Glyoxalase PF00903.25 AIF83774.1 - 5.8e-14 52.4 0.0 7.5e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 AIF83774.1 - 4.2e-12 46.0 0.0 7.1e-12 45.3 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 AIF83774.1 - 0.00022 22.0 0.0 0.00028 21.7 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 AIF83774.1 - 0.0054 17.0 0.0 0.097 13.0 0.0 2.1 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Ig_mannosidase PF17753.1 AIF83775.1 - 0.057 13.2 0.0 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 Ig-fold domain Methyltransf_11 PF08241.12 AIF83776.1 - 1.1e-16 61.2 0.1 4.1e-16 59.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF83776.1 - 2e-16 60.1 0.0 3.6e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF83776.1 - 4e-16 59.5 0.2 3.3e-15 56.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF83776.1 - 1.7e-11 44.2 0.0 2.9e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF83776.1 - 3e-09 36.6 0.1 1.7e-07 30.8 0.0 2.7 3 0 0 3 3 3 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 AIF83776.1 - 3.3e-09 37.4 0.0 3.1e-08 34.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 AIF83776.1 - 0.009 15.6 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 AIF83776.1 - 0.096 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) zf-C2H2 PF00096.26 AIF83777.1 - 0.00032 21.0 0.4 0.00032 21.0 0.4 2.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF83777.1 - 0.00045 20.8 0.4 0.00045 20.8 0.4 2.4 2 1 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AIF83777.1 - 0.0011 18.9 0.1 0.0011 18.9 0.1 2.7 3 0 0 3 3 3 1 C2H2-type zinc finger Tmemb_55A PF09788.9 AIF83777.1 - 0.041 13.0 0.2 0.041 13.0 0.2 1.1 1 0 0 1 1 1 0 Transmembrane protein 55A zf-C2HC_2 PF13913.6 AIF83777.1 - 0.076 12.9 0.1 0.076 12.9 0.1 2.0 2 1 0 2 2 2 0 zinc-finger of a C2HC-type DUF4674 PF15719.5 AIF83777.1 - 0.11 12.6 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) DUF2298 PF10060.9 AIF83779.1 - 0.021 13.6 0.3 0.023 13.4 0.3 1.0 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) Claudin_3 PF06653.11 AIF83779.1 - 0.036 14.0 0.2 0.044 13.7 0.2 1.0 1 0 0 1 1 1 0 Tight junction protein, Claudin-like Trp_oprn_chp PF09534.10 AIF83779.1 - 0.04 13.7 0.6 0.05 13.4 0.6 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) TEX29 PF15839.5 AIF83779.1 - 0.046 14.3 0.1 0.12 13.0 0.0 1.6 1 1 1 2 2 2 0 Testis-expressed sequence 29 protein Hol_Tox PF16935.5 AIF83779.1 - 0.06 13.4 0.7 0.11 12.5 0.1 1.7 1 1 1 2 2 2 0 Putative Holin-like Toxin (Hol-Tox) EphA2_TM PF14575.6 AIF83779.1 - 0.061 14.2 1.2 1.2 10.0 0.1 2.1 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF2157 PF09925.9 AIF83779.1 - 0.18 11.6 0.1 0.18 11.6 0.1 2.1 1 1 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF2207 PF09972.9 AIF83779.1 - 0.29 9.8 0.3 0.33 9.7 0.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF202 PF02656.15 AIF83779.1 - 1.6 9.2 4.7 3.2 8.3 3.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF202) Putative_PNPOx PF01243.20 AIF83780.1 - 3.8e-20 71.9 0.0 4.9e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AIF83780.1 - 5.3e-13 49.2 0.0 6.4e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIF83780.1 - 1.1e-05 25.1 0.0 1.3e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like MtrA PF04208.14 AIF83781.1 - 6.9e-26 90.9 0.4 8.1e-26 90.7 0.4 1.0 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit A dUTPase_2 PF08761.11 AIF83782.1 - 3.1e-18 66.5 3.1 4.5e-13 49.7 0.3 2.0 1 1 1 2 2 2 2 dUTPase PRA-PH PF01503.17 AIF83782.1 - 0.0019 18.6 0.0 0.0024 18.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase DUF550 PF04447.12 AIF83782.1 - 0.016 15.3 0.4 0.036 14.2 0.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF550) OMS28_porin PF03532.13 AIF83783.1 - 0.00059 19.1 0.1 0.00093 18.5 0.1 1.3 1 0 0 1 1 1 1 OMS28 porin Glycos_transf_2 PF00535.26 AIF83784.1 - 8.8e-37 126.5 0.0 1.4e-36 125.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 GtrA PF04138.14 AIF83784.1 - 1.4e-20 73.6 11.5 1.9e-19 70.0 12.6 2.0 1 1 0 1 1 1 1 GtrA-like protein Glyco_tranf_2_3 PF13641.6 AIF83784.1 - 6.1e-14 52.5 0.0 1.2e-13 51.5 0.0 1.5 2 0 0 2 2 2 1 Glycosyltransferase like family 2 NTP_transf_3 PF12804.7 AIF83784.1 - 9.1e-06 26.1 0.0 1.5e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glyco_transf_21 PF13506.6 AIF83784.1 - 0.002 17.6 0.0 0.0049 16.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 AIF83784.1 - 0.13 12.8 0.0 0.26 11.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Rad51 PF08423.11 AIF83785.1 - 1.3e-30 106.5 0.0 1.5e-30 106.3 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 AIF83785.1 - 2.1e-09 37.2 0.0 2.7e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 AIF83785.1 - 3.4e-08 33.3 1.6 4e-07 29.8 1.6 2.0 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 AIF83785.1 - 1.9e-07 30.7 1.1 1.2e-05 24.8 0.3 2.1 1 1 0 2 2 2 1 KaiC AAA_24 PF13479.6 AIF83785.1 - 0.00041 20.1 0.0 0.00056 19.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIF83785.1 - 0.00075 19.9 0.0 0.00095 19.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 AIF83785.1 - 0.0011 19.1 0.0 0.0019 18.2 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ATPase_2 PF01637.18 AIF83785.1 - 0.011 15.6 0.0 0.015 15.2 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Zot PF05707.12 AIF83785.1 - 0.012 15.3 0.0 0.014 15.0 0.0 1.1 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) IstB_IS21 PF01695.17 AIF83785.1 - 0.021 14.6 0.0 0.04 13.7 0.0 1.4 1 1 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 AIF83785.1 - 0.032 14.7 0.1 0.055 14.0 0.1 1.6 1 1 0 1 1 1 0 ABC transporter TrwB_AAD_bind PF10412.9 AIF83785.1 - 0.036 13.0 0.0 0.087 11.7 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.22 AIF83785.1 - 0.058 13.8 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 AIF83785.1 - 0.06 13.3 0.0 0.11 12.5 0.0 1.4 1 1 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 AIF83785.1 - 0.06 13.6 0.3 0.21 11.9 0.3 1.9 1 1 0 1 1 1 0 AAA domain CLP1_P PF16575.5 AIF83785.1 - 0.097 12.5 0.1 0.21 11.3 0.0 1.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA PF00004.29 AIF83785.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ICAP-1_inte_bdg PF10480.9 AIF83785.1 - 0.13 12.2 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Beta-1 integrin binding protein MMR_HSR1 PF01926.23 AIF83785.1 - 0.13 12.3 0.0 1.7 8.8 0.0 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase PAXNEB PF05625.11 AIF83785.1 - 0.39 9.8 1.6 0.56 9.3 0.6 1.6 2 0 0 2 2 2 0 PAXNEB protein LSM PF01423.22 AIF83786.1 - 7.4e-19 67.2 1.1 8.3e-19 67.1 1.1 1.0 1 0 0 1 1 1 1 LSM domain S-AdoMet_synt_C PF02773.16 AIF83787.1 - 5e-69 230.6 0.7 7e-69 230.1 0.1 1.5 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 AIF83787.1 - 3.1e-46 156.5 0.0 9.2e-46 155.0 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 AIF83787.1 - 4.1e-43 146.1 0.7 1.1e-42 144.7 0.0 2.1 3 0 0 3 3 3 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 AIF83787.1 - 0.071 11.9 0.2 1.5 7.5 0.1 2.5 2 1 1 3 3 3 0 S-adenosylmethionine synthetase (AdoMet synthetase) adh_short_C2 PF13561.6 AIF83788.1 - 3.2e-57 193.8 2.9 3.7e-57 193.6 2.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 AIF83788.1 - 4.7e-49 166.5 0.7 6e-49 166.2 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AIF83788.1 - 2.9e-13 50.1 0.1 4.3e-13 49.6 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AIF83788.1 - 0.0016 17.9 0.3 0.012 15.1 0.2 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 AIF83788.1 - 0.0021 18.3 0.0 0.0043 17.3 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 AIF83788.1 - 0.0053 16.7 0.6 0.0071 16.3 0.6 1.6 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 AIF83788.1 - 0.0076 15.4 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain THF_DHG_CYH_C PF02882.19 AIF83788.1 - 0.053 12.8 0.0 0.2 11.0 0.0 1.8 1 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain CbiD PF01888.17 AIF83789.1 - 3.9e-89 298.3 6.2 4.9e-89 298.0 6.2 1.1 1 0 0 1 1 1 1 CbiD HTH_AsnC-type PF13404.6 AIF83790.1 - 6.3e-14 51.5 0.1 1.8e-13 50.0 0.1 1.8 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 AIF83790.1 - 5.6e-12 45.0 0.1 9.3e-12 44.3 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Arc_trans_TRASH PF08394.10 AIF83790.1 - 8.5e-06 26.0 3.4 1.8e-05 24.9 3.4 1.6 1 0 0 1 1 1 1 Archaeal TRASH domain TrmB PF01978.19 AIF83790.1 - 7.9e-05 22.5 0.1 0.00015 21.6 0.0 1.4 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Tnp_ISL3 PF13542.6 AIF83790.1 - 0.00076 18.8 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_5 PF01022.20 AIF83790.1 - 0.0015 18.3 0.0 0.0023 17.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family zf-FCS PF06467.14 AIF83790.1 - 0.0057 16.6 3.6 0.012 15.5 3.6 1.6 1 0 0 1 1 1 1 MYM-type Zinc finger with FCS sequence motif HTH_9 PF08221.11 AIF83790.1 - 0.0094 16.0 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain DUF2250 PF10007.9 AIF83790.1 - 0.015 15.4 0.3 0.027 14.6 0.3 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) DUF2089 PF09862.9 AIF83790.1 - 0.026 14.5 0.3 0.075 13.1 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2089) PyrI_C PF02748.15 AIF83790.1 - 0.045 13.6 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Sigma70_r4_2 PF08281.12 AIF83790.1 - 0.061 13.0 0.1 0.3 10.8 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 Lar_restr_allev PF14354.6 AIF83790.1 - 0.082 13.3 1.3 0.16 12.4 1.3 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar HTH_38 PF13936.6 AIF83790.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.7 AIF83790.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 MarR family RuvB_C PF05491.13 AIF83790.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 RuvB C-terminal winged helix domain zf-C2H2_4 PF13894.6 AIF83790.1 - 0.13 13.2 2.4 16 6.6 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger HTH_IclR PF09339.10 AIF83790.1 - 0.21 11.4 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF2423 PF10338.9 AIF83790.1 - 0.25 11.6 1.3 0.31 11.3 0.1 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF2423) FeoC PF09012.10 AIF83790.1 - 0.39 10.8 0.0 0.39 10.8 0.0 2.4 3 0 0 3 3 3 0 FeoC like transcriptional regulator ADK_lid PF05191.14 AIF83790.1 - 0.96 9.5 4.5 0.76 9.8 0.4 2.2 2 0 0 2 2 2 0 Adenylate kinase, active site lid PMT_2 PF13231.6 AIF83791.1 - 1.4e-12 48.1 10.4 1.4e-12 48.1 10.4 2.8 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT PF02366.18 AIF83791.1 - 9.5e-12 45.0 11.4 9.5e-12 45.0 11.4 3.0 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_2 PF13231.6 AIF83792.1 - 1.2e-09 38.6 13.3 1.2e-09 38.6 13.3 3.8 2 1 2 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF3382 PF11862.8 AIF83792.1 - 0.21 11.9 0.1 0.21 11.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3382) DUF5381 PF17353.2 AIF83792.1 - 1.1 9.0 5.8 0.61 9.8 1.3 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5381) DUF2157 PF09925.9 AIF83792.1 - 1.8 8.3 0.0 1.8 8.3 0.0 4.7 4 2 0 4 4 4 0 Predicted membrane protein (DUF2157) Acyl_transf_3 PF01757.22 AIF83792.1 - 4.7 6.2 41.6 6.4 5.7 7.8 3.4 1 1 2 3 3 3 0 Acyltransferase family CbiG_N PF11760.8 AIF83793.1 - 1.8e-32 111.2 0.4 1.8e-32 111.2 0.4 1.9 2 0 0 2 2 2 1 Cobalamin synthesis G N-terminal CbiG_C PF01890.16 AIF83793.1 - 5.5e-29 101.1 0.0 1.1e-28 100.1 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis G C-terminus CbiG_mid PF11761.8 AIF83793.1 - 1.2e-17 63.8 0.1 5.7e-17 61.6 0.1 2.1 2 0 0 2 2 2 1 Cobalamin biosynthesis central region CbiC PF02570.15 AIF83794.1 - 1.5e-73 246.7 0.5 2.9e-73 245.7 0.2 1.7 2 0 0 2 2 2 1 Precorrin-8X methylmutase CbiX PF01903.17 AIF83794.1 - 2e-35 121.3 0.1 1.3e-16 60.8 0.1 2.4 2 0 0 2 2 2 2 CbiX CbiK PF06180.11 AIF83794.1 - 1e-10 41.4 0.1 1.5e-10 40.9 0.1 1.2 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) Ferrochelatase PF00762.19 AIF83794.1 - 0.11 11.5 0.0 2.7 7.0 0.0 2.3 1 1 1 2 2 2 0 Ferrochelatase GATase_3 PF07685.14 AIF83795.1 - 2.7e-40 138.1 0.0 3.8e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain CbiA PF01656.23 AIF83795.1 - 1.6e-18 67.0 0.1 3.2e-18 66.0 0.1 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 AIF83795.1 - 2.4e-15 56.9 1.2 1.8e-10 41.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain SNO PF01174.19 AIF83795.1 - 0.016 15.1 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 SNO glutamine amidotransferase family AAA_18 PF13238.6 AIF83795.1 - 0.083 13.4 0.0 0.31 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain CTP_synth_N PF06418.14 AIF83795.1 - 0.18 11.1 0.1 0.3 10.3 0.1 1.3 1 0 0 1 1 1 0 CTP synthase N-terminus bPH_3 PF14470.6 AIF83796.1 - 2.3e-12 47.1 0.0 3.5e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial PH domain SHOCT PF09851.9 AIF83796.1 - 8.1e-05 22.2 1.5 0.0002 21.0 1.5 1.7 1 0 0 1 1 1 1 Short C-terminal domain CobA_CobO_BtuR PF02572.15 AIF83797.1 - 4.6e-60 202.8 0.4 5e-60 202.7 0.4 1.0 1 0 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP IstB_IS21 PF01695.17 AIF83797.1 - 0.01 15.6 0.5 2.9 7.6 0.0 2.1 2 0 0 2 2 2 2 IstB-like ATP binding protein EIF_2_alpha PF07541.12 AIF83798.1 - 1.5e-18 66.9 2.5 2.1e-18 66.5 0.2 2.3 3 1 0 3 3 3 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 AIF83798.1 - 2e-12 47.3 0.4 4.5e-12 46.1 0.1 1.8 2 0 0 2 2 2 1 S1 RNA binding domain Skp1_POZ PF03931.15 AIF83798.1 - 0.068 13.3 0.2 0.14 12.3 0.2 1.6 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Nop10p PF04135.12 AIF83799.1 - 2.1e-21 75.7 4.7 2.6e-21 75.4 4.7 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family PolC_DP2 PF03833.13 AIF83799.1 - 0.0034 15.3 0.4 0.0034 15.3 0.4 1.0 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 RecR PF02132.15 AIF83799.1 - 0.0072 15.9 1.3 0.0085 15.6 1.3 1.2 1 0 0 1 1 1 1 RecR protein zf-tcix PF14952.6 AIF83799.1 - 0.048 13.3 3.8 0.071 12.7 0.1 2.1 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding DUF35_N PF12172.8 AIF83799.1 - 0.15 11.9 3.8 0.35 10.8 3.8 1.6 1 1 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) HypA PF01155.19 AIF83799.1 - 0.3 11.1 1.4 0.37 10.8 1.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ACC PF17848.1 AIF83799.1 - 0.78 9.9 7.0 15 5.7 1.4 2.3 1 1 1 2 2 2 0 Acetyl-coA carboxylase zinc finger domain zf-ribbon_3 PF13248.6 AIF83799.1 - 0.87 9.1 7.1 1.3 8.6 1.0 2.1 1 1 0 2 2 2 0 zinc-ribbon domain NAD_binding_8 PF13450.6 AIF83800.1 - 0.00092 19.4 0.0 0.0021 18.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 AIF83800.1 - 0.0033 16.3 0.0 0.09 11.6 0.0 2.2 2 0 0 2 2 2 1 Tryptophan halogenase ApbA PF02558.16 AIF83800.1 - 0.0053 16.4 0.0 0.0092 15.6 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 AIF83800.1 - 0.18 12.4 0.0 0.43 11.2 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_transf_4 PF13439.6 AIF83800.1 - 0.19 11.7 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 FAD_binding_3 PF01494.19 AIF83800.1 - 0.24 10.6 0.0 0.5 9.5 0.0 1.5 2 0 0 2 2 2 0 FAD binding domain 4HBT PF03061.22 AIF83801.1 - 1.2e-17 64.0 0.3 1.7e-17 63.5 0.3 1.2 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.19 AIF83801.1 - 0.0023 17.5 0.1 0.0035 16.9 0.1 1.3 1 0 0 1 1 1 1 MaoC like domain PEP_mutase PF13714.6 AIF83803.1 - 3e-54 184.0 0.0 3.4e-54 183.8 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 AIF83803.1 - 7.4e-13 47.8 0.0 1.6e-12 46.7 0.0 1.4 1 1 0 1 1 1 1 Isocitrate lyase family Glyoxalase PF00903.25 AIF83804.1 - 1.6e-10 41.2 0.0 2.6e-10 40.6 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 AIF83804.1 - 4.8e-07 29.7 0.0 7.5e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 AIF83804.1 - 7.7e-05 23.4 0.0 9.8e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain DUF2757 PF10955.8 AIF83805.1 - 0.00075 19.7 0.9 0.00092 19.4 0.3 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2757) TFIIS_C PF01096.18 AIF83805.1 - 0.0046 16.8 0.6 0.11 12.3 0.2 2.2 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) zinc-ribbons_6 PF07191.12 AIF83805.1 - 0.013 15.5 0.1 0.015 15.3 0.1 1.3 1 1 0 1 1 1 0 zinc-ribbons DUF3268 PF11672.8 AIF83805.1 - 0.019 15.3 0.1 0.021 15.2 0.1 1.1 1 0 0 1 1 1 0 zinc-finger-containing domain Zn_Tnp_IS1595 PF12760.7 AIF83805.1 - 0.27 11.2 4.3 0.67 10.0 4.3 1.7 1 1 0 1 1 1 0 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.12 AIF83807.1 - 0.01 15.3 0.3 2 8.0 0.1 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 AIF83807.1 - 0.016 15.1 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Elf1 PF05129.13 AIF83807.1 - 0.017 15.1 1.1 4.3 7.4 0.0 2.1 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-RING_5 PF14634.6 AIF83807.1 - 0.027 14.5 0.8 0.046 13.7 0.8 1.4 1 0 0 1 1 1 0 zinc-RING finger domain HypA PF01155.19 AIF83807.1 - 0.029 14.4 0.1 0.036 14.1 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 AIF83807.1 - 0.043 13.2 1.0 0.88 9.1 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.6 AIF83807.1 - 0.044 13.7 0.2 2.9 7.9 0.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_10 PF10058.9 AIF83807.1 - 0.081 12.7 0.5 0.17 11.6 0.5 1.6 1 1 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein Staygreen PF12638.7 AIF83807.1 - 0.09 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Staygreen protein CpXC PF14353.6 AIF83807.1 - 0.11 12.5 0.9 3 7.9 0.0 2.1 1 1 1 2 2 2 0 CpXC protein zf-C2HE PF16278.5 AIF83807.1 - 0.11 12.9 1.8 0.83 10.2 0.2 2.4 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_5 PF13719.6 AIF83807.1 - 0.28 11.0 3.4 0.46 10.3 0.5 2.3 2 1 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 AIF83807.1 - 0.3 11.3 1.8 0.74 10.0 1.5 1.8 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 AIF83807.1 - 0.32 11.0 2.7 7.1 6.8 0.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 AIF83807.1 - 0.43 11.5 1.7 9.7 7.3 0.2 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger HTH_24 PF13412.6 AIF83808.1 - 4.8e-07 29.2 0.1 8e-07 28.5 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF83808.1 - 2e-05 24.3 0.5 3.5e-05 23.5 0.5 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_5 PF01022.20 AIF83808.1 - 0.00085 19.1 0.1 0.0015 18.4 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR PF01047.22 AIF83808.1 - 0.0025 17.7 0.0 0.0046 16.9 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 AIF83808.1 - 0.0031 17.5 0.0 0.0063 16.6 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_IclR PF09339.10 AIF83808.1 - 0.0033 17.2 0.0 0.0057 16.4 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 AIF83808.1 - 0.0083 16.0 0.1 0.019 14.9 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB AsnC_trans_reg PF01037.21 AIF83808.1 - 0.0084 16.1 0.1 0.019 14.9 0.0 1.5 2 0 0 2 2 2 1 Lrp/AsnC ligand binding domain Sigma70_r4_2 PF08281.12 AIF83808.1 - 0.082 12.6 0.1 0.24 11.1 0.0 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 AMMECR1 PF01871.17 AIF83809.1 - 1.6e-44 151.4 0.0 1.9e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 Glyco_trans_1_3 PF13528.6 AIF83810.1 - 5.8e-15 55.4 0.0 7.8e-07 28.6 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.16 AIF83810.1 - 3.6e-12 46.6 0.0 7e-12 45.6 0.0 1.5 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 AIF83810.1 - 1.4e-07 30.7 0.0 4e-07 29.2 0.0 1.7 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glycos_transf_1 PF00534.20 AIF83810.1 - 0.0002 20.9 0.0 0.00052 19.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AIF83810.1 - 0.016 15.6 0.0 0.039 14.4 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 THUMP PF02926.17 AIF83811.1 - 0.033 14.3 0.7 0.1 12.7 0.2 2.0 2 1 0 2 2 2 0 THUMP domain His_biosynth PF00977.21 AIF83811.1 - 0.077 12.5 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein FixQ PF05545.11 AIF83812.1 - 0.003 17.5 2.5 0.0041 17.1 2.5 1.2 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ DUF347 PF03988.12 AIF83812.1 - 0.074 13.3 1.9 0.12 12.6 1.9 1.3 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) Ribosomal_S13_N PF08069.12 AIF83814.1 - 1.3e-24 86.0 0.7 2.5e-24 85.1 0.3 1.7 2 0 0 2 2 2 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 AIF83814.1 - 2.3e-10 40.5 0.4 3.9e-10 39.8 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 AIF83814.1 - 0.043 13.7 0.0 0.07 13.1 0.0 1.4 1 0 0 1 1 1 0 'Paired box' domain HTHP PF11534.8 AIF83814.1 - 0.09 13.2 0.1 3 8.3 0.0 2.6 2 1 1 3 3 3 0 Hexameric tyrosine-coordinated heme protein (HTHP) DDE_Tnp_IS1 PF03400.13 AIF83814.1 - 0.12 12.8 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 IS1 transposase DHHA1 PF02272.19 AIF83815.1 - 9.3e-07 29.3 0.0 2.2e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.20 AIF83815.1 - 0.0027 17.9 0.1 0.0052 17.0 0.1 1.5 1 0 0 1 1 1 1 DHH family NTP_transf_4 PF13562.6 AIF83815.1 - 0.2 11.9 0.0 0.36 11.0 0.0 1.3 1 0 0 1 1 1 0 Sugar nucleotidyl transferase Pcc1 PF09341.10 AIF83816.1 - 0.00012 22.1 0.4 0.00046 20.3 0.4 1.8 1 1 0 1 1 1 1 Transcription factor Pcc1 DUF2089 PF09862.9 AIF83816.1 - 0.14 12.2 0.0 0.81 9.7 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2089) tRNA-synt_2b PF00587.25 AIF83817.1 - 2.4e-38 131.9 0.1 4.3e-38 131.1 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 AIF83817.1 - 6.5e-24 84.2 9.3 1.2e-23 83.4 9.3 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain UPF0228 PF05727.11 AIF83817.1 - 0.02 14.7 0.0 0.097 12.5 0.0 2.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0228) LAM_C PF12544.8 AIF83817.1 - 0.034 14.3 0.7 0.48 10.6 0.0 2.8 3 1 0 3 3 3 0 Lysine-2,3-aminomutase FmiP_Thoc5 PF09766.9 AIF83817.1 - 0.2 10.9 5.1 0.33 10.2 5.1 1.3 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 Macoilin PF09726.9 AIF83817.1 - 1.7 7.1 6.7 2.4 6.6 6.7 1.1 1 0 0 1 1 1 0 Macoilin family Ribosomal_S3Ae PF01015.18 AIF83818.1 - 1.5e-55 187.9 1.1 1.8e-55 187.7 1.1 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family RNA_binding PF01877.17 AIF83819.1 - 2.4e-25 89.1 0.0 2.8e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 RNA binding RNase_P_p30 PF01876.16 AIF83820.1 - 0.032 13.7 0.0 0.039 13.4 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit p30 RNase_P_Rpp14 PF01900.19 AIF83821.1 - 0.0024 18.1 0.0 0.0026 18.0 0.0 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family Radical_SAM PF04055.21 AIF83822.1 - 6.6e-16 59.1 0.1 9.5e-15 55.4 0.1 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.6 AIF83822.1 - 0.0047 17.1 0.0 0.75 10.0 0.0 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain Polysacc_deac_1 PF01522.21 AIF83823.1 - 4.3e-12 46.0 0.0 7.5e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIF83823.1 - 1.2e-07 31.6 0.0 2.3e-07 30.7 0.0 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_hydro_57 PF03065.15 AIF83823.1 - 0.0013 18.0 0.0 0.0039 16.4 0.0 1.7 1 1 0 2 2 2 1 Glycosyl hydrolase family 57 UPF0180 PF03698.13 AIF83823.1 - 0.022 14.9 0.0 4.4 7.5 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) N6_N4_Mtase PF01555.18 AIF83823.1 - 0.027 14.2 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 DNA methylase PhoU_div PF01865.16 AIF83824.1 - 6.8e-16 58.2 4.9 8.2e-16 58.0 4.9 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 PhoU PF01895.19 AIF83824.1 - 0.0069 16.8 6.2 0.49 10.9 2.3 2.6 2 1 0 2 2 2 2 PhoU domain Lebercilin PF15619.6 AIF83824.1 - 0.04 13.6 6.3 0.027 14.2 2.6 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TraD PF06412.11 AIF83824.1 - 0.11 12.3 0.5 0.73 9.7 0.1 2.3 2 0 0 2 2 2 0 Conjugal transfer protein TraD tRNA_int_endo PF01974.17 AIF83825.1 - 1.4e-26 92.3 0.1 2.5e-26 91.6 0.1 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 AIF83825.1 - 2.4e-17 62.3 0.0 4.3e-17 61.5 0.0 1.5 1 1 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain RB_B PF01857.20 AIF83826.1 - 0.086 12.9 0.4 0.17 12.0 0.1 1.6 2 0 0 2 2 2 0 Retinoblastoma-associated protein B domain HIT PF01230.23 AIF83828.1 - 7.5e-24 84.3 0.9 7.6e-24 84.3 0.2 1.4 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 AIF83828.1 - 2.1e-13 50.7 0.1 3.1e-13 50.2 0.1 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 AIF83828.1 - 0.0095 15.8 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 ApoA-II PF04711.13 AIF83829.1 - 0.0017 18.5 0.0 0.0032 17.6 0.0 1.4 1 0 0 1 1 1 1 Apolipoprotein A-II (ApoA-II) SAPI PF16560.5 AIF83829.1 - 0.0097 15.5 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Putative mobile pathogenicity island DUF915 PF06028.11 AIF83829.1 - 0.064 12.6 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF2267 PF10025.9 AIF83829.1 - 0.08 13.2 0.0 0.3 11.4 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) Elf1 PF05129.13 AIF83830.1 - 0.0038 17.2 0.2 0.0045 17.0 0.2 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 AIF83830.1 - 0.0089 15.9 0.1 4.7 7.2 0.0 2.2 2 0 0 2 2 2 2 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIF83830.1 - 0.026 14.4 0.2 0.031 14.2 0.2 1.1 1 0 0 1 1 1 0 Putative transposase DNA-binding domain HypA PF01155.19 AIF83830.1 - 0.055 13.5 0.1 0.058 13.4 0.1 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_10 PF18414.1 AIF83830.1 - 0.086 12.4 0.3 0.17 11.4 0.3 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger Zn-ribbon_8 PF09723.10 AIF83830.1 - 0.13 12.4 2.9 0.36 11.0 2.9 1.7 1 1 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_5 PF13719.6 AIF83830.1 - 0.49 10.2 4.4 3.1 7.6 0.2 2.0 1 1 1 2 2 2 0 zinc-ribbon domain zf-C2H2 PF00096.26 AIF83830.1 - 0.72 10.4 3.2 24 5.6 1.1 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type C1_2 PF03107.16 AIF83830.1 - 1.4 9.3 4.6 6.2 7.2 0.7 2.1 1 1 1 2 2 2 0 C1 domain Phage_integrase PF00589.22 AIF83831.1 - 4e-13 49.5 1.1 4e-13 49.5 1.1 1.9 2 1 0 2 2 2 1 Phage integrase family Sugarporin_N PF11471.8 AIF83831.1 - 0.008 16.1 2.0 0.016 15.1 2.0 1.5 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension Phage_int_SAM_5 PF13102.6 AIF83831.1 - 0.047 14.0 7.1 0.68 10.3 0.1 3.8 3 1 0 3 3 3 0 Phage integrase SAM-like domain zf-HIT PF04438.16 AIF83832.1 - 0.074 12.9 0.9 0.074 12.9 0.9 6.1 5 1 0 5 5 5 0 HIT zinc finger zf-C6H2 PF15801.5 AIF83832.1 - 0.32 11.3 42.0 0.12 12.8 1.7 5.5 3 2 2 5 5 5 0 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 AIF83832.1 - 0.52 10.4 40.2 0.12 12.5 3.0 5.2 4 1 0 4 4 4 0 MYND finger DUF2116 PF09889.9 AIF83832.1 - 4.6 7.3 31.1 0.16 12.0 1.9 5.3 3 2 2 5 5 5 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Nop53 PF07767.11 AIF83833.1 - 0.22 10.9 16.2 0.23 10.8 16.2 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) APG6_N PF17675.1 AIF83833.1 - 1.1 9.8 15.2 1.2 9.6 15.2 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region TAF8_C PF10406.9 AIF83833.1 - 3.3 8.4 6.9 0.55 10.8 1.5 2.2 1 1 1 2 2 2 0 Transcription factor TFIID complex subunit 8 C-term DUF3391 PF11871.8 AIF83833.1 - 3.3 8.3 8.6 3.7 8.1 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) MscS_TM PF12794.7 AIF83833.1 - 7.4 5.3 9.4 7.6 5.3 9.4 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 eIF3_subunit PF08597.10 AIF83833.1 - 9.4 6.1 16.5 11 5.8 16.5 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF4083 PF13314.6 AIF83834.1 - 0.079 12.9 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Prim-Pol PF09250.11 AIF83835.1 - 4.8e-12 46.5 0.0 8.9e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Bifunctional DNA primase/polymerase, N-terminal D5_N PF08706.11 AIF83835.1 - 1.8e-11 44.5 0.8 1.8e-11 44.5 0.8 2.0 2 0 0 2 2 2 1 D5 N terminal like Pox_D5 PF03288.16 AIF83835.1 - 0.0066 16.9 0.0 0.027 14.9 0.0 2.0 1 0 0 1 1 1 1 Poxvirus D5 protein-like RFX_DNA_binding PF02257.15 AIF83835.1 - 0.052 14.2 0.2 0.24 12.1 0.2 2.1 1 0 0 1 1 1 0 RFX DNA-binding domain HypA PF01155.19 AIF83837.1 - 0.012 15.6 0.2 0.014 15.4 0.2 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1360 PF07098.11 AIF83837.1 - 0.015 15.3 0.1 0.015 15.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1360) zinc_ribbon_4 PF13717.6 AIF83837.1 - 0.021 14.7 0.2 5.6 7.0 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf_Rg PF17915.1 AIF83837.1 - 0.038 13.4 0.2 0.52 9.8 0.0 2.1 2 0 0 2 2 2 0 Reverse gyrase zinc finger DNA_RNApol_7kD PF03604.13 AIF83837.1 - 0.061 13.0 2.1 1.6 8.5 0.5 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Zn-ribbon_8 PF09723.10 AIF83837.1 - 0.13 12.4 1.9 0.27 11.4 2.0 1.5 1 1 0 1 1 1 0 Zinc ribbon domain Lar_restr_allev PF14354.6 AIF83837.1 - 0.17 12.3 3.3 4.2 7.8 0.5 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar zinc_ribbon_2 PF13240.6 AIF83837.1 - 0.25 11.1 3.6 1 9.2 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain UPF0547 PF10571.9 AIF83837.1 - 0.44 10.7 7.4 0.74 9.9 1.2 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Ribosomal_L32p PF01783.23 AIF83837.1 - 1.3 9.4 4.3 1.7 8.9 0.5 2.1 1 1 1 2 2 2 0 Ribosomal L32p protein family MazE_antitoxin PF04014.18 AIF83838.1 - 2.1e-06 27.5 0.1 3.1e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin Phage-tail_3 PF13550.6 AIF83838.1 - 0.055 13.3 0.0 0.067 13.0 0.0 1.3 1 1 0 1 1 1 0 Putative phage tail protein DUF2083 PF09856.9 AIF83840.1 - 0.056 13.3 0.1 0.056 13.3 0.1 1.0 1 0 0 1 1 1 0 Predicted transcriptional regulator (DUF2083) Spc7 PF08317.11 AIF83841.1 - 0.031 13.2 3.1 0.075 11.9 3.1 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5611 PF18446.1 AIF83841.1 - 0.48 11.3 2.4 2 9.3 0.4 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5611) GPS2_interact PF15784.5 AIF83841.1 - 2.5 8.6 5.1 1.4 9.4 0.6 2.9 2 1 1 3 3 3 0 G-protein pathway suppressor 2-interacting domain DUF2080 PF09853.9 AIF83842.1 - 0.0075 16.0 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 Putative transposon-encoded protein (DUF2080) Phage_integrase PF00589.22 AIF83843.1 - 6.6e-15 55.3 0.0 1.2e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Phage integrase family HHH_8 PF14716.6 AIF83843.1 - 0.12 12.7 0.3 4 7.9 0.1 2.6 2 1 0 2 2 2 0 Helix-hairpin-helix domain ILVD_EDD PF00920.21 AIF83844.1 - 2.5e-212 706.1 10.6 2.8e-212 705.9 10.6 1.0 1 0 0 1 1 1 1 Dehydratase family Chorismate_bind PF00425.18 AIF83845.1 - 1e-96 323.5 0.0 8.4e-96 320.5 0.0 2.0 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 AIF83845.1 - 6.5e-26 91.2 0.0 4.3e-22 78.9 0.0 2.5 2 1 0 2 2 2 2 Anthranilate synthase component I, N terminal region MerR PF00376.23 AIF83845.1 - 0.052 13.3 0.0 4.7 7.1 0.0 2.6 2 0 0 2 2 2 0 MerR family regulatory protein PALP PF00291.25 AIF83846.1 - 1.8e-50 172.1 0.0 2.3e-50 171.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PK_C PF02887.16 AIF83846.1 - 0.18 12.0 2.5 1.8 8.8 1.2 2.6 2 1 0 2 2 2 0 Pyruvate kinase, alpha/beta domain Acetyltransf_1 PF00583.25 AIF83848.1 - 1.6e-12 47.7 0.2 1.9e-12 47.4 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AIF83848.1 - 7e-10 38.9 0.1 9.8e-10 38.5 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AIF83848.1 - 1.3e-09 38.3 0.3 2.2e-09 37.6 0.3 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AIF83848.1 - 5.2e-05 23.4 0.0 6.7e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 AIF83848.1 - 0.0013 19.4 0.0 0.0017 19.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 AIF83848.1 - 0.06 13.0 0.0 0.22 11.2 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Microvir_H PF04687.12 AIF83849.1 - 0.022 14.2 0.6 0.035 13.5 0.6 1.3 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) Ins_allergen_rp PF06757.13 AIF83849.1 - 0.034 14.1 0.1 0.049 13.6 0.1 1.2 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification Snf7 PF03357.21 AIF83849.1 - 0.093 12.3 5.6 0.17 11.5 5.6 1.5 1 1 0 1 1 1 0 Snf7 DASH_Duo1 PF08651.10 AIF83849.1 - 0.21 11.4 1.9 1.6 8.6 0.2 2.3 2 0 0 2 2 2 0 DASH complex subunit Duo1 Aminotran_1_2 PF00155.21 AIF83851.1 - 7.7e-57 193.1 0.1 8.8e-57 192.9 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 AIF83851.1 - 0.0015 17.2 0.0 0.0021 16.7 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 AIF83851.1 - 0.025 13.9 0.2 1.3 8.2 0.0 2.2 2 0 0 2 2 2 0 Beta-eliminating lyase BATS PF06968.13 AIF83852.1 - 1.8e-15 56.8 0.0 1.6e-14 53.8 0.0 2.3 3 0 0 3 3 3 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 AIF83852.1 - 2.2e-14 54.2 0.4 4.2e-14 53.3 0.4 1.4 1 0 0 1 1 1 1 Radical SAM superfamily DeoC PF01791.9 AIF83852.1 - 0.017 14.8 0.0 3.9 7.0 0.0 2.3 2 0 0 2 2 2 0 DeoC/LacD family aldolase Fibrillarin_2 PF10113.9 AIF83852.1 - 0.088 11.4 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin-like archaeal protein AraC_binding PF02311.19 AIF83853.1 - 4.2e-07 29.9 0.0 4.8e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 AIF83853.1 - 6.2e-07 29.0 0.0 8.2e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Cupin domain EutQ PF06249.12 AIF83853.1 - 0.00033 20.5 0.0 0.00042 20.1 0.0 1.2 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.12 AIF83853.1 - 0.0015 18.2 0.1 0.0023 17.6 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_6 PF12852.7 AIF83853.1 - 0.0025 17.6 0.0 0.0025 17.6 0.0 1.1 1 0 0 1 1 1 1 Cupin Rep_1 PF01446.17 AIF83855.1 - 2.4e-07 30.5 0.5 3.7e-07 29.9 0.5 1.2 1 0 0 1 1 1 1 Replication protein TF_Zn_Ribbon PF08271.12 AIF83856.1 - 5.9e-05 22.5 22.6 0.013 15.0 3.0 4.7 4 1 1 5 5 5 3 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 AIF83856.1 - 0.00029 20.9 22.0 0.0019 18.2 2.7 4.7 4 1 0 4 4 4 1 Zinc ribbon domain OrfB_Zn_ribbon PF07282.11 AIF83856.1 - 0.0013 18.6 2.2 0.0013 18.6 2.2 3.6 2 1 2 4 4 4 2 Putative transposase DNA-binding domain DZR PF12773.7 AIF83856.1 - 0.0017 18.4 20.5 0.025 14.6 7.1 3.6 2 1 1 3 3 3 1 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 AIF83856.1 - 0.0019 18.1 17.9 0.059 13.4 4.1 3.9 4 0 0 4 4 4 2 Transposase zinc-ribbon domain zinc_ribbon_10 PF10058.9 AIF83856.1 - 0.0052 16.5 1.1 0.0052 16.5 1.1 4.3 5 0 0 5 5 5 2 Predicted integral membrane zinc-ribbon metal-binding protein Ribosomal_S27e PF01667.17 AIF83856.1 - 0.01 15.5 0.9 0.01 15.5 0.9 3.7 4 1 0 4 4 4 0 Ribosomal protein S27 zf-MIZ PF02891.20 AIF83856.1 - 0.02 14.7 3.1 1.3 8.8 0.2 2.7 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Lar_restr_allev PF14354.6 AIF83856.1 - 0.026 14.9 3.8 0.026 14.9 3.8 3.7 1 1 2 3 3 3 0 Restriction alleviation protein Lar HypA PF01155.19 AIF83856.1 - 0.062 13.3 17.0 0.41 10.7 0.7 3.2 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_9 PF14369.6 AIF83856.1 - 0.076 13.3 2.0 0.076 13.3 2.0 4.2 3 1 1 4 4 4 0 zinc-ribbon DNA_RNApol_7kD PF03604.13 AIF83856.1 - 0.5 10.1 0.1 0.5 10.1 0.1 4.4 4 1 1 5 5 4 0 DNA directed RNA polymerase, 7 kDa subunit Zn_Tnp_IS1 PF03811.13 AIF83856.1 - 0.56 10.0 15.3 0.18 11.5 4.3 4.0 4 0 0 4 4 4 0 InsA N-terminal domain eIF-5_eIF-2B PF01873.17 AIF83856.1 - 0.87 9.5 9.3 0.091 12.6 1.9 2.5 2 0 0 2 2 2 0 Domain found in IF2B/IF5 IBR PF01485.21 AIF83856.1 - 1.3 9.3 24.3 0.43 10.8 3.0 3.6 2 1 2 4 4 4 0 IBR domain, a half RING-finger domain zf-ribbon_3 PF13248.6 AIF83856.1 - 1.4 8.5 18.5 28 4.3 0.2 5.1 4 1 0 4 4 4 0 zinc-ribbon domain zinc_ribbon_15 PF17032.5 AIF83856.1 - 1.4 9.7 20.0 4.6 8.1 2.6 3.4 2 1 1 3 3 3 0 zinc-ribbon family DUF3268 PF11672.8 AIF83856.1 - 2.2 8.6 10.6 0.53 10.6 1.4 3.2 1 1 1 3 3 3 0 zinc-finger-containing domain Elf1 PF05129.13 AIF83856.1 - 4 7.6 21.6 0.28 11.2 5.1 3.8 1 1 3 4 4 4 0 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 AIF83856.1 - 4.8 7.2 25.2 6 6.9 0.2 5.4 4 1 1 5 5 5 0 zinc-ribbon domain zf-ISL3 PF14690.6 AIF83856.1 - 5.9 7.6 24.1 4.6 8.0 0.6 5.8 6 1 1 7 7 7 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 DUF2752 PF10825.8 AIF83856.1 - 7.8 6.6 9.4 33 4.7 0.4 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2752) HisK_sensor PF18698.1 AIF83858.1 - 0.019 15.3 0.0 0.029 14.7 0.0 1.2 1 0 0 1 1 1 0 Histidine kinase sensor domain DUF485 PF04341.12 AIF83858.1 - 0.063 13.2 0.6 1.5 8.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Gp45_2 PF17470.2 AIF83859.1 - 0.11 12.5 0.1 1.9 8.5 0.1 2.3 2 0 0 2 2 2 0 Phage gene product 45.2 AAA_16 PF13191.6 AIF83860.1 - 2.1e-05 25.0 0.0 3.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 AIF83860.1 - 0.0015 17.8 0.0 0.0049 16.1 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain ATPase_2 PF01637.18 AIF83860.1 - 0.0031 17.5 0.0 0.0088 16.0 0.0 1.6 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea ResIII PF04851.15 AIF83860.1 - 0.0034 17.4 0.0 0.0051 16.8 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Pox_A32 PF04665.12 AIF83860.1 - 0.0036 16.8 0.1 0.0098 15.4 0.0 1.8 1 1 1 2 2 2 1 Poxvirus A32 protein AAA PF00004.29 AIF83860.1 - 0.017 15.6 0.1 1 9.8 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PPK2 PF03976.14 AIF83860.1 - 0.026 14.0 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) AAA_25 PF13481.6 AIF83860.1 - 0.026 14.1 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AIF83860.1 - 0.028 14.0 0.1 0.066 12.7 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF815 PF05673.13 AIF83860.1 - 0.037 13.2 0.0 0.046 12.9 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF815) EIID-AGA PF03613.14 AIF83860.1 - 0.062 12.5 0.0 0.093 11.9 0.0 1.2 1 0 0 1 1 1 0 PTS system mannose/fructose/sorbose family IID component NACHT PF05729.12 AIF83860.1 - 0.11 12.4 0.1 0.27 11.1 0.0 1.6 2 0 0 2 2 2 0 NACHT domain Activator_LAG-3 PF11498.8 AIF83861.1 - 0.0089 15.0 0.1 0.009 15.0 0.1 1.0 1 0 0 1 1 1 1 Transcriptional activator LAG-3 CD20 PF04103.15 AIF83861.1 - 0.026 14.6 0.0 0.033 14.3 0.0 1.1 1 0 0 1 1 1 0 CD20-like family DUF3333 PF11812.8 AIF83862.1 - 0.17 12.1 0.2 0.17 12.1 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3333) E1-E2_ATPase PF00122.20 AIF83862.1 - 0.19 11.2 1.4 0.22 11.0 1.4 1.0 1 0 0 1 1 1 0 E1-E2 ATPase DUF5357 PF17310.2 AIF83862.1 - 0.24 9.9 0.4 0.26 9.8 0.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5357) Baculo_E56 PF04639.12 AIF83865.1 - 0.028 13.7 0.1 0.035 13.4 0.1 1.1 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope Big_3_5 PF16640.5 AIF83866.1 - 0.044 14.0 0.2 0.08 13.1 0.2 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) PP1 PF07430.11 AIF83867.1 - 0.011 15.8 0.0 0.03 14.4 0.0 1.7 1 0 0 1 1 1 0 Phloem filament protein PP1 cystatin-like domain DUF2214 PF09980.9 AIF83868.1 - 0.037 13.8 0.4 0.056 13.3 0.2 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2214) SKG6 PF08693.10 AIF83868.1 - 0.2 11.1 1.6 6.3 6.3 0.2 2.2 2 0 0 2 2 2 0 Transmembrane alpha-helix domain DUF202 PF02656.15 AIF83868.1 - 0.25 11.8 4.2 0.52 10.8 4.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF485 PF04341.12 AIF83868.1 - 1 9.4 3.7 8.5 6.4 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Podoplanin PF05808.11 AIF83868.1 - 5.8 7.0 7.7 1.1 9.4 0.1 2.0 1 1 1 2 2 2 0 Podoplanin Resolvase PF00239.21 AIF83869.1 - 1.7e-33 115.8 0.2 2.7e-33 115.1 0.2 1.3 1 0 0 1 1 1 1 Resolvase, N terminal domain HTH_7 PF02796.15 AIF83869.1 - 4.7e-07 29.8 0.1 9.8e-07 28.8 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 AIF83869.1 - 7.3e-06 25.6 0.2 7.3e-06 25.6 0.2 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.6 AIF83869.1 - 4e-05 23.3 0.2 4e-05 23.3 0.2 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_30 PF13556.6 AIF83869.1 - 0.00056 19.7 0.1 0.0011 18.7 0.1 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain CENP-B_N PF04218.13 AIF83869.1 - 0.00069 19.2 0.5 0.0033 17.0 0.1 2.3 3 0 0 3 3 3 1 CENP-B N-terminal DNA-binding domain HTH_8 PF02954.19 AIF83869.1 - 0.0019 17.9 0.6 0.0019 17.9 0.6 2.2 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family HTH_Tnp_1_2 PF13022.6 AIF83869.1 - 0.0022 18.2 0.1 0.036 14.2 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix of insertion element transposase HTH_10 PF04967.12 AIF83869.1 - 0.0043 16.8 0.2 0.01 15.6 0.2 1.6 1 0 0 1 1 1 1 HTH DNA binding domain HTH_22 PF13309.6 AIF83869.1 - 0.0046 17.0 0.1 0.015 15.4 0.0 2.0 2 0 0 2 2 1 1 HTH domain HTH_28 PF13518.6 AIF83869.1 - 0.007 16.5 1.1 0.016 15.3 0.2 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_11 PF08279.12 AIF83869.1 - 0.0078 16.1 0.5 0.019 14.9 0.5 1.7 1 0 0 1 1 1 1 HTH domain TetR_N PF00440.23 AIF83869.1 - 0.013 15.2 0.0 0.031 14.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_29 PF13551.6 AIF83869.1 - 0.014 15.4 1.3 0.14 12.2 0.1 2.4 1 1 1 2 2 2 0 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 AIF83869.1 - 0.015 14.7 0.0 0.044 13.2 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_Tnp_1 PF01527.20 AIF83869.1 - 0.05 13.9 0.4 0.11 12.9 0.0 1.7 2 0 0 2 2 1 0 Transposase HTH_50 PF18024.1 AIF83869.1 - 0.054 13.1 0.6 0.18 11.5 0.2 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain TrmB PF01978.19 AIF83869.1 - 0.14 12.1 0.2 0.27 11.1 0.2 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Mga PF05043.13 AIF83869.1 - 0.14 12.7 0.2 0.41 11.3 0.1 1.8 2 0 0 2 2 2 0 Mga helix-turn-helix domain Aminotran_3 PF00202.21 AIF83870.1 - 2.2e-94 316.4 0.0 2.7e-94 316.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III FAD_binding_2 PF00890.24 AIF83870.1 - 0.014 14.5 0.0 0.05 12.7 0.0 1.9 3 0 0 3 3 3 0 FAD binding domain Beta_elim_lyase PF01212.21 AIF83870.1 - 0.075 12.3 0.0 0.17 11.1 0.0 1.5 2 0 0 2 2 2 0 Beta-eliminating lyase Repressor_Mnt PF11423.8 AIF83870.1 - 0.29 10.9 1.3 1 9.2 1.3 2.0 1 0 0 1 1 1 0 Regulatory protein Mnt CLZ PF16526.5 AIF83870.1 - 1.3 9.4 4.8 14 6.1 0.0 3.3 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels AAA_26 PF13500.6 AIF83871.1 - 2.9e-38 131.7 0.0 3.5e-38 131.4 0.0 1.0 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 AIF83871.1 - 9.1e-09 35.4 0.0 1.8e-08 34.5 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 AIF83871.1 - 0.0026 17.2 0.2 0.4 10.1 0.0 2.3 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase CTP_synth_N PF06418.14 AIF83871.1 - 0.0042 16.4 0.3 0.023 14.0 0.2 2.0 3 0 0 3 3 3 1 CTP synthase N-terminus DUF1611 PF07755.11 AIF83871.1 - 0.03 13.6 2.1 0.095 12.0 0.7 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1611_C) P-loop domain ResIII PF04851.15 AIF83871.1 - 0.058 13.4 0.4 0.098 12.6 0.4 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Dicty_CAD PF05720.12 AIF83872.1 - 0.064 13.2 0.0 5.4 7.1 0.0 2.2 2 0 0 2 2 2 0 Cell-cell adhesion domain DUF2157 PF09925.9 AIF83873.1 - 0.38 10.5 5.8 0.47 10.2 0.8 2.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) SLAC1 PF03595.17 AIF83873.1 - 0.49 9.6 6.7 0.6 9.3 6.7 1.2 1 0 0 1 1 1 0 Voltage-dependent anion channel DUF3995 PF13160.6 AIF83873.1 - 3.5 8.0 9.0 0.78 10.1 5.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3995) NTP_transferase PF00483.23 AIF83874.1 - 7.8e-36 123.9 0.0 1.5e-35 123.0 0.0 1.4 1 1 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 AIF83874.1 - 2.4e-07 31.2 0.0 3.4e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 AIF83874.1 - 0.0098 15.6 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Bac_luciferase PF00296.20 AIF83875.1 - 2.7e-64 217.6 0.0 3.1e-64 217.4 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Thiolase_N PF00108.23 AIF83876.1 - 2.3e-13 50.1 8.4 3.5e-11 43.0 5.8 3.5 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AIF83876.1 - 1.2e-10 41.1 0.4 3.7e-10 39.5 0.4 1.9 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 AIF83876.1 - 1.5e-05 24.8 0.5 0.00029 20.6 0.2 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 AIF83876.1 - 0.00017 21.3 0.8 0.00027 20.6 0.1 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 AIF83876.1 - 0.0045 17.0 4.6 0.019 15.0 1.3 3.1 1 1 1 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain DUF35_N PF12172.8 AIF83877.1 - 1.7e-07 31.0 1.8 3.2e-07 30.1 1.8 1.5 1 0 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-C3HC4_2 PF13923.6 AIF83877.1 - 1.4 8.9 5.7 2.4 8.1 5.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS1595 PF12760.7 AIF83877.1 - 3 7.9 7.7 0.62 10.1 1.7 2.2 1 1 1 2 2 2 0 Transposase zinc-ribbon domain DUF4357 PF14267.6 AIF83879.1 - 0.076 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4357) HATPase_c PF02518.26 AIF83880.1 - 2.7e-26 92.3 0.1 7.7e-26 90.8 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIF83880.1 - 1.9e-11 43.8 0.7 7.8e-11 41.9 0.7 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PLDc_2 PF13091.6 AIF83880.1 - 8.5e-05 22.5 0.1 0.0011 18.8 0.0 2.6 2 0 0 2 2 2 1 PLD-like domain HATPase_c_3 PF13589.6 AIF83880.1 - 0.0018 18.1 0.0 0.0044 16.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 AIF83880.1 - 0.0053 16.6 0.0 0.019 14.9 0.0 1.9 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.6 AIF83880.1 - 0.0076 16.2 0.0 0.018 15.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain Regulator_TrmB PF11495.8 AIF83880.1 - 0.0089 15.2 1.5 0.019 14.2 0.9 1.9 1 1 0 1 1 1 1 Archaeal transcriptional regulator TrmB Ribosomal_L6 PF00347.23 AIF83881.1 - 5.1e-18 65.5 11.3 6.2e-10 39.6 3.6 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 DUF2067 PF09840.9 AIF83881.1 - 0.051 13.1 2.8 0.14 11.7 0.5 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2067) DUF3858 PF12970.7 AIF83881.1 - 0.13 12.3 0.2 0.51 10.4 0.1 1.9 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3858) Glyco_hydro_65C PF03633.15 AIF83881.1 - 0.14 12.0 1.9 13 5.8 0.2 3.2 2 1 1 3 3 3 0 Glycosyl hydrolase family 65, C-terminal domain Ribosomal_S8 PF00410.19 AIF83882.1 - 1.7e-24 86.2 0.0 2.1e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S14 PF00253.21 AIF83883.1 - 3.5e-10 39.5 4.1 5e-10 39.0 4.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S14p/S29e zf-tcix PF14952.6 AIF83883.1 - 0.002 17.7 0.9 0.002 17.7 0.9 1.7 2 0 0 2 2 2 1 Putative treble-clef, zinc-finger, Zn-binding Ribosomal_L5_C PF00673.21 AIF83884.1 - 2e-22 79.2 0.0 3.4e-22 78.4 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 AIF83884.1 - 7.3e-15 55.1 0.2 1.4e-14 54.1 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 Ribosomal_S4e PF00900.20 AIF83885.1 - 4.5e-16 58.5 0.0 1.3e-15 57.0 0.0 1.8 2 0 0 2 2 2 1 Ribosomal family S4e RS4NT PF08071.12 AIF83885.1 - 5e-10 39.3 0.4 7.9e-10 38.7 0.4 1.3 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 AIF83885.1 - 9.3e-06 25.3 0.2 2.1e-05 24.1 0.2 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 AIF83885.1 - 0.015 15.2 0.1 0.061 13.3 0.1 2.1 1 0 0 1 1 1 0 KOW motif Ribosomal_L26 PF16906.5 AIF83886.1 - 9.6e-19 67.6 0.1 1.7e-18 66.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 AIF83886.1 - 2.1e-05 24.3 5.6 5.5e-05 23.0 5.6 1.8 1 1 0 1 1 1 1 KOW motif CMAS PF02353.20 AIF83886.1 - 0.062 12.6 0.1 0.091 12.0 0.1 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase RR_TM4-6 PF06459.12 AIF83886.1 - 0.33 10.7 6.0 0.38 10.5 6.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AP3D1 PF06375.11 AIF83886.1 - 8.4 6.6 12.9 5.6 7.2 11.6 1.4 1 1 0 1 1 1 0 AP-3 complex subunit delta-1 Ribosomal_L14 PF00238.19 AIF83887.1 - 4.7e-33 113.9 0.1 5.9e-33 113.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Ribosomal_S17 PF00366.20 AIF83888.1 - 4.2e-23 81.2 1.4 5.2e-23 80.9 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 DUF4411 PF14367.6 AIF83888.1 - 0.039 13.9 0.0 0.046 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) Ribosomal_S17_N PF16205.5 AIF83888.1 - 0.04 14.3 0.0 0.086 13.2 0.0 1.6 1 0 0 1 1 1 0 Ribosomal_S17 N-terminal UPF0086 PF01868.16 AIF83889.1 - 6.9e-18 64.4 0.0 7.9e-18 64.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Ribosomal_L29 PF00831.23 AIF83890.1 - 4.9e-15 55.2 3.6 6.3e-15 54.9 3.6 1.2 1 0 0 1 1 1 1 Ribosomal L29 protein Ribosomal_S3_C PF00189.20 AIF83891.1 - 7.6e-20 71.2 1.8 1.5e-19 70.3 1.1 1.8 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 AIF83891.1 - 3.3e-13 49.3 0.0 5.6e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 KH domain Ribosomal_L22 PF00237.19 AIF83892.1 - 9.5e-26 90.0 1.0 1.3e-25 89.6 1.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribosomal_S19 PF00203.21 AIF83893.1 - 2.1e-28 98.0 0.1 2.7e-28 97.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_L23 PF00276.20 AIF83894.1 - 2.5e-12 47.0 1.2 4.4e-12 46.2 1.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 Lipoprotein_1 PF00820.19 AIF83894.1 - 0.029 13.4 1.0 0.029 13.4 1.0 1.2 1 0 0 1 1 1 0 Borrelia lipoprotein Ribosomal_L4 PF00573.22 AIF83895.1 - 4.3e-36 124.4 0.7 5e-36 124.2 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribosomal_L3 PF00297.22 AIF83896.1 - 2e-71 241.0 2.7 1.2e-70 238.3 2.7 1.8 1 1 0 1 1 1 1 Ribosomal protein L3 DUF3710 PF12502.8 AIF83896.1 - 0.073 12.7 0.2 9.3 5.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3710) Methyltrn_RNA_3 PF02598.17 AIF83897.1 - 5.2e-53 180.4 0.0 5.9e-53 180.2 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase SPOUT_MTase_2 PF14419.6 AIF83897.1 - 3.9e-05 23.1 0.1 6.2e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 AF2226-like SPOUT RNA Methylase fused to THUMP Redoxin PF08534.10 AIF83898.1 - 2.9e-08 33.5 0.0 6.7e-06 25.9 0.0 2.2 2 1 0 2 2 2 2 Redoxin AhpC-TSA PF00578.21 AIF83898.1 - 4.2e-08 33.1 0.0 2.2e-06 27.6 0.0 2.2 1 1 0 1 1 1 1 AhpC/TSA family GSHPx PF00255.19 AIF83898.1 - 0.0023 17.5 0.0 0.0049 16.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin_2 PF13098.6 AIF83898.1 - 0.053 14.0 0.1 0.53 10.8 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain Proteasome PF00227.26 AIF83899.1 - 1.6e-57 194.1 0.6 2.2e-57 193.7 0.6 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AIF83899.1 - 2e-14 52.9 1.0 1.4e-13 50.2 0.1 2.6 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature P_proprotein PF01483.20 AIF83899.1 - 0.19 11.8 0.0 0.75 9.9 0.0 2.0 2 1 1 3 3 3 0 Proprotein convertase P-domain Promethin PF16015.5 AIF83900.1 - 0.0055 16.6 0.8 0.0062 16.4 0.8 1.2 1 0 0 1 1 1 1 Promethin DUF4179 PF13786.6 AIF83900.1 - 0.25 11.9 2.6 0.27 11.7 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) DUF371 PF04027.13 AIF83901.1 - 6.5e-46 155.6 0.5 7.2e-46 155.5 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF371) HTH_20 PF12840.7 AIF83902.1 - 4.6e-11 42.6 0.3 1.1e-10 41.4 0.2 1.7 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 AIF83902.1 - 8.9e-10 38.3 0.1 6.7e-09 35.5 0.1 2.2 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family PadR PF03551.14 AIF83902.1 - 1.9e-05 24.5 0.2 5e-05 23.2 0.1 1.7 2 0 0 2 2 2 1 Transcriptional regulator PadR-like family HTH_12 PF08461.10 AIF83902.1 - 5.3e-05 23.1 0.0 0.00013 21.9 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain TrmB PF01978.19 AIF83902.1 - 0.0027 17.5 0.1 0.0074 16.1 0.1 1.6 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Ribosomal_L12 PF00542.19 AIF83902.1 - 0.0047 17.3 0.5 1.7 9.0 0.0 2.6 1 1 1 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain MarR_2 PF12802.7 AIF83902.1 - 0.011 15.6 0.1 0.047 13.6 0.1 2.0 1 1 0 1 1 1 0 MarR family TBPIP PF07106.13 AIF83902.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 TBPIP/Hop2 winged helix domain FUR PF01475.19 AIF83902.1 - 0.013 15.6 0.0 0.023 14.9 0.0 1.3 1 0 0 1 1 1 0 Ferric uptake regulator family DUF4423 PF14394.6 AIF83902.1 - 0.025 14.3 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Type2_restr_D3 PF16902.5 AIF83902.1 - 0.034 14.1 0.0 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain HTH_11 PF08279.12 AIF83902.1 - 0.036 14.0 0.0 0.43 10.6 0.0 2.2 1 1 0 1 1 1 0 HTH domain HTH_IclR PF09339.10 AIF83902.1 - 0.065 13.0 0.8 0.31 10.9 0.3 2.3 2 1 0 2 2 2 0 IclR helix-turn-helix domain TFIIE_alpha PF02002.17 AIF83902.1 - 0.066 13.1 0.0 0.16 11.9 0.0 1.6 2 0 0 2 2 2 0 TFIIE alpha subunit DprA_WH PF17782.1 AIF83902.1 - 0.071 13.2 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 DprA winged helix domain Ntox27 PF15531.6 AIF83902.1 - 0.1 12.5 0.1 0.22 11.4 0.1 1.5 1 1 0 1 1 1 0 Bacterial toxin 27 DBR1 PF05011.13 AIF83902.1 - 0.11 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain HTH_24 PF13412.6 AIF83902.1 - 0.13 11.8 0.0 1.1 8.8 0.0 2.5 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding SAICAR_synt PF01259.18 AIF83903.1 - 1.1e-69 234.8 0.0 1.3e-69 234.6 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase ATP-grasp PF02222.22 AIF83904.1 - 7.3e-59 198.2 0.1 1.1e-58 197.6 0.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 AIF83904.1 - 6.3e-17 61.0 0.0 1.2e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 AIF83904.1 - 1.2e-06 28.2 0.1 4.9e-06 26.2 0.1 1.9 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.11 AIF83904.1 - 6.7e-06 25.8 0.1 1.3e-05 24.9 0.1 1.4 1 1 0 1 1 1 1 RimK-like ATP-grasp domain LAL_C2 PF18603.1 AIF83904.1 - 7.8e-05 22.8 0.2 0.00024 21.2 0.2 1.8 1 1 0 1 1 1 1 L-amino acid ligase C-terminal domain 2 2-Hacid_dh_C PF02826.19 AIF83904.1 - 0.00016 21.1 0.0 0.00036 19.9 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ATPgrasp_ST PF14397.6 AIF83904.1 - 0.0009 18.6 0.2 0.17 11.1 0.1 2.2 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_5 PF13549.6 AIF83904.1 - 0.012 15.1 0.0 0.022 14.2 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain 3HCDH_N PF02737.18 AIF83904.1 - 0.032 14.1 0.0 0.067 13.1 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.6 AIF83904.1 - 0.034 14.6 0.0 0.067 13.7 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain ATPgrasp_YheCD PF14398.6 AIF83904.1 - 0.036 13.3 0.1 0.4 9.9 0.0 2.1 1 1 0 2 2 2 0 YheC/D like ATP-grasp GARS_A PF01071.19 AIF83904.1 - 0.039 13.7 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_2 PF08442.10 AIF83904.1 - 0.057 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain Pyr_redox_2 PF07992.14 AIF83904.1 - 0.07 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 AIF83904.1 - 0.12 12.6 0.3 1.2 9.4 0.0 2.6 2 1 0 2 2 2 0 TrkA-N domain NAD_binding_2 PF03446.15 AIF83904.1 - 0.14 12.3 0.1 0.87 9.7 0.0 2.2 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase AIRC PF00731.20 AIF83905.1 - 4.5e-68 227.5 1.5 5.4e-68 227.2 1.5 1.1 1 0 0 1 1 1 1 AIR carboxylase CoA_binding_2 PF13380.6 AIF83905.1 - 0.043 14.3 0.1 9.6 6.7 0.0 2.2 1 1 1 2 2 2 0 CoA binding domain Nif11 PF07862.11 AIF83907.1 - 0.097 13.0 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 Nif11 domain Phage_B PF02304.15 AIF83908.1 - 0.04 14.3 0.0 0.099 13.0 0.0 1.7 1 0 0 1 1 1 0 Scaffold protein B SMG1 PF15785.5 AIF83908.1 - 0.19 10.1 0.0 0.25 9.7 0.0 1.1 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 CDC48_N PF02359.18 AIF83909.1 - 1.3e-20 73.4 0.0 3.4e-20 72.0 0.0 1.7 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain CDC48_2 PF02933.17 AIF83909.1 - 0.00021 21.0 0.1 0.00068 19.4 0.1 1.9 1 1 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 adh_short PF00106.25 AIF83910.1 - 3.4e-45 153.9 0.1 6.5e-40 136.7 0.1 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AIF83910.1 - 1.5e-42 145.8 1.1 2.6e-32 112.2 0.0 3.1 3 0 0 3 3 3 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIF83910.1 - 3e-15 56.6 0.5 1.4e-10 41.4 0.1 3.1 3 1 0 3 3 3 2 KR domain Epimerase PF01370.21 AIF83910.1 - 6.7e-06 25.7 0.3 0.0091 15.5 0.0 2.7 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 AIF83910.1 - 0.00056 19.8 0.5 0.00056 19.8 0.5 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIF83910.1 - 0.002 17.5 0.8 0.0041 16.5 0.2 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 AIF83910.1 - 0.025 15.2 2.3 0.043 14.4 0.2 2.5 3 0 0 3 3 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 AIF83910.1 - 0.031 14.7 0.8 0.13 12.7 0.1 2.4 2 1 0 2 2 2 0 Putative NAD(P)-binding ApbA PF02558.16 AIF83910.1 - 0.035 13.7 0.2 3.7 7.2 0.1 2.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA THF_DHG_CYH_C PF02882.19 AIF83910.1 - 0.036 13.4 0.2 0.17 11.2 0.0 2.2 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GRDA PF04723.14 AIF83910.1 - 0.28 11.0 4.9 20 4.9 0.0 3.9 4 0 0 4 4 4 0 Glycine reductase complex selenoprotein A NIBRIN_BRCT_II PF16508.5 AIF83910.1 - 0.39 11.0 1.5 13 6.2 0.1 2.7 3 0 0 3 3 3 0 Second BRCT domain on Nijmegen syndrome breakage protein NAD_binding_10 PF13460.6 AIF83910.1 - 5.6 6.8 8.4 4.5 7.1 0.3 3.4 3 1 0 3 3 3 0 NAD(P)H-binding TauE PF01925.19 AIF83911.1 - 5.3e-53 180.1 35.1 6.4e-53 179.8 35.1 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE DUF5423 PF17461.2 AIF83911.1 - 0.9 8.3 9.5 0.16 10.8 0.2 2.4 3 0 0 3 3 3 0 Family of unknown function (DUF5423) HTH_AsnC-type PF13404.6 AIF83912.1 - 7.1e-12 45.0 1.4 8.6e-12 44.7 0.2 1.8 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 AIF83912.1 - 4.8e-10 39.3 0.0 7.9e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 AIF83912.1 - 1.2e-09 37.5 0.5 2.7e-09 36.5 0.5 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 AIF83912.1 - 0.00011 22.1 0.1 0.00026 20.9 0.1 1.6 1 0 0 1 1 1 1 HTH domain NapD PF03927.13 AIF83912.1 - 0.00015 21.7 0.2 0.0003 20.8 0.2 1.4 1 0 0 1 1 1 1 NapD protein HTH_DeoR PF08220.12 AIF83912.1 - 0.0011 18.7 0.3 0.0019 17.9 0.3 1.3 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HrcA_DNA-bdg PF03444.15 AIF83912.1 - 0.0026 17.4 0.1 0.0061 16.2 0.1 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding Adeno_PX PF05829.12 AIF83912.1 - 0.0035 17.2 0.6 0.0079 16.0 0.6 1.6 1 0 0 1 1 1 1 Adenovirus late L2 mu core protein (Protein X) HTH_Crp_2 PF13545.6 AIF83912.1 - 0.005 16.8 0.1 0.018 15.0 0.1 1.9 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain Sigma70_r4_2 PF08281.12 AIF83912.1 - 0.012 15.2 0.2 0.028 14.1 0.2 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 MarR PF01047.22 AIF83912.1 - 0.015 15.2 0.1 0.037 14.0 0.1 1.6 1 0 0 1 1 1 0 MarR family FaeA PF04703.12 AIF83912.1 - 0.034 14.5 0.1 7.7 7.0 0.0 2.3 1 1 1 2 2 2 0 FaeA-like protein DUF2250 PF10007.9 AIF83912.1 - 0.055 13.6 0.0 1.7 8.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) MarR_2 PF12802.7 AIF83912.1 - 0.061 13.2 0.7 0.27 11.1 0.1 2.1 2 0 0 2 2 2 0 MarR family HTH_5 PF01022.20 AIF83912.1 - 0.084 12.8 0.0 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_23 PF13384.6 AIF83912.1 - 0.093 12.6 0.8 0.19 11.6 0.1 1.9 2 0 0 2 2 2 0 Homeodomain-like domain TrmB PF01978.19 AIF83912.1 - 0.097 12.6 0.1 0.73 9.8 0.0 2.2 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB Sigma70_r4 PF04545.16 AIF83912.1 - 0.11 12.1 0.2 0.25 10.9 0.1 1.6 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_Mga PF08280.11 AIF83912.1 - 0.11 12.5 0.0 0.21 11.7 0.0 1.5 2 0 0 2 2 1 0 M protein trans-acting positive regulator (MGA) HTH domain Homoserine_dh PF00742.19 AIF83913.1 - 8.5e-54 182.1 0.2 1.5e-53 181.3 0.2 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 AIF83913.1 - 1.1e-07 32.6 0.1 2.9e-07 31.1 0.0 1.8 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 AIF83913.1 - 2.8e-06 27.2 0.1 7.1e-06 25.9 0.1 1.6 1 1 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GFO_IDH_MocA PF01408.22 AIF83913.1 - 0.1 13.4 0.0 0.23 12.3 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold DZR PF12773.7 AIF83914.1 - 0.0031 17.5 0.5 0.0048 16.9 0.5 1.3 1 1 0 1 1 1 1 Double zinc ribbon Phage_integrase PF00589.22 AIF83915.1 - 1e-07 31.9 0.2 4.3e-07 29.9 0.2 2.0 1 1 0 1 1 1 1 Phage integrase family zf-HIT PF04438.16 AIF83916.1 - 0.0011 18.7 20.4 0.04 13.8 2.2 3.7 3 0 0 3 3 3 2 HIT zinc finger DUF1272 PF06906.11 AIF83916.1 - 0.011 15.9 11.8 0.6 10.2 1.6 3.3 2 1 0 3 3 3 0 Protein of unknown function (DUF1272) HscB_4_cys PF18256.1 AIF83916.1 - 0.014 15.2 20.7 0.024 14.5 5.5 3.0 3 0 0 3 3 3 0 Co-chaperone HscB tetracysteine metal binding motif NinG PF05766.12 AIF83916.1 - 0.27 11.2 8.1 0.88 9.5 2.2 2.3 2 1 0 2 2 2 0 Bacteriophage Lambda NinG protein zf-C2HC5 PF06221.13 AIF83916.1 - 0.29 11.2 12.0 7.5 6.6 0.4 3.6 2 1 1 3 3 3 0 Putative zinc finger motif, C2HC5-type XPA_N PF01286.18 AIF83916.1 - 0.4 10.8 5.8 2.9 8.0 0.2 2.9 3 0 0 3 3 3 0 XPA protein N-terminal Zn-ribbon_8 PF09723.10 AIF83916.1 - 0.63 10.2 7.7 8.7 6.6 0.8 3.3 2 1 1 3 3 3 0 Zinc ribbon domain zf-MYND PF01753.18 AIF83916.1 - 0.67 10.1 20.1 3.1 8.0 2.5 3.4 2 1 0 2 2 2 0 MYND finger DUF2688 PF10892.8 AIF83916.1 - 1.3 8.6 7.9 11 5.5 0.3 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2688) DUF3090 PF11290.8 AIF83916.1 - 3.1 7.6 6.6 3.1 7.6 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3090) zf-C6H2 PF15801.5 AIF83916.1 - 5.2 7.5 16.1 3 8.2 0.6 3.6 3 0 0 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding RPAP2_Rtr1 PF04181.13 AIF83916.1 - 7.5 7.0 14.5 11 6.4 0.4 3.4 2 1 1 3 3 3 0 Rtr1/RPAP2 family DZR PF12773.7 AIF83916.1 - 9.1 6.4 18.9 4.9 7.3 9.1 3.1 1 1 1 2 2 2 0 Double zinc ribbon DUF3496 PF12001.8 AIF83917.1 - 0.013 15.9 3.5 0.013 15.9 2.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3496) DUF501 PF04417.12 AIF83917.1 - 0.35 10.7 2.4 0.47 10.3 1.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF501) Nop53 PF07767.11 AIF83917.1 - 0.38 10.1 14.4 0.43 9.9 14.4 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TAF8_C PF10406.9 AIF83917.1 - 1.4 9.5 5.9 0.24 12.0 1.0 2.2 2 1 0 2 2 2 0 Transcription factor TFIID complex subunit 8 C-term Collectrin PF16959.5 AIF83920.1 - 0.7 9.7 2.2 1.1 9.0 2.2 1.3 1 0 0 1 1 1 0 Renal amino acid transporter MSP1a PF11670.8 AIF83923.1 - 0.16 11.3 0.2 0.22 10.8 0.2 1.2 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) CopG_antitoxin PF12441.8 AIF83924.1 - 0.00099 19.6 0.2 0.0024 18.4 0.2 1.6 1 0 0 1 1 1 1 CopG antitoxin of type II toxin-antitoxin system RHH_1 PF01402.21 AIF83924.1 - 0.0098 15.8 0.3 0.096 12.7 0.0 2.3 2 0 0 2 2 2 1 Ribbon-helix-helix protein, copG family KH_5 PF13184.6 AIF83924.1 - 0.012 15.7 0.0 0.047 13.8 0.0 2.0 2 0 0 2 2 2 0 NusA-like KH domain MG2 PF01835.19 AIF83926.1 - 0.0048 17.3 1.5 0.0094 16.4 0.1 2.1 2 1 0 2 2 2 1 MG2 domain DUF4784 PF16023.5 AIF83926.1 - 0.0063 15.5 0.0 0.01 14.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4784) TIG PF01833.24 AIF83926.1 - 0.014 15.5 2.1 0.035 14.2 2.1 1.7 1 0 0 1 1 1 0 IPT/TIG domain DUF1980 PF09323.10 AIF83926.1 - 0.45 10.4 4.3 14 5.5 4.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) ATP-synt_B PF00430.18 AIF83926.1 - 4.2 7.5 13.2 21 5.2 13.2 2.0 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Mid2 PF04478.12 AIF83926.1 - 7.6 6.4 10.3 0.12 12.2 0.8 2.6 3 0 0 3 3 3 0 Mid2 like cell wall stress sensor Glycos_transf_1 PF00534.20 AIF83928.1 - 7.3e-21 74.4 0.0 1.1e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AIF83928.1 - 5.8e-09 36.5 0.0 1e-08 35.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 AIF83928.1 - 0.02 15.3 0.0 0.038 14.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 ALG11_N PF15924.5 AIF83928.1 - 0.031 14.3 4.0 0.89 9.6 3.8 2.8 2 1 0 2 2 2 0 ALG11 mannosyltransferase N-terminus CBS PF00571.28 AIF83929.1 - 1.8e-12 47.5 0.1 2.4e-12 47.1 0.1 1.2 1 0 0 1 1 1 1 CBS domain GAGA PF09237.11 AIF83929.1 - 0.0061 16.3 0.6 0.011 15.6 0.1 1.6 2 0 0 2 2 2 1 GAGA factor zf-Di19 PF05605.12 AIF83929.1 - 0.014 15.7 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding IF3_N PF05198.16 AIF83929.1 - 0.056 13.7 0.1 0.12 12.6 0.0 1.6 1 1 1 2 2 2 0 Translation initiation factor IF-3, N-terminal domain DUF72 PF01904.18 AIF83932.1 - 5.7e-12 46.2 0.0 6.1e-12 46.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 DUF72 PF01904.18 AIF83933.1 - 4.7e-15 56.3 0.0 5.6e-15 56.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 zf-TFIIB PF13453.6 AIF83935.1 - 0.0012 18.1 1.8 0.26 10.7 0.4 2.3 2 0 0 2 2 2 2 Transcription factor zinc-finger DUF1451 PF07295.11 AIF83935.1 - 0.018 15.1 0.2 0.026 14.6 0.2 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain zinc_ribbon_10 PF10058.9 AIF83935.1 - 0.024 14.4 1.0 0.041 13.6 1.0 1.4 1 1 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein DNA_ligase_ZBD PF03119.16 AIF83935.1 - 0.037 14.1 0.6 0.037 14.1 0.6 1.7 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Zn-ribbon_8 PF09723.10 AIF83935.1 - 0.038 14.1 0.7 0.086 13.0 0.7 1.5 1 1 0 1 1 1 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 AIF83935.1 - 0.044 13.2 2.2 0.067 12.6 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain Nudix_N_2 PF14803.6 AIF83935.1 - 0.38 10.7 3.7 2.2 8.3 0.6 2.3 2 0 0 2 2 2 0 Nudix N-terminal Cys_rich_CPCC PF14206.6 AIF83935.1 - 0.39 10.6 3.1 2.4 8.0 0.1 2.1 1 1 1 2 2 2 0 Cysteine-rich CPCC DUF3482 PF11981.8 AIF83936.1 - 0.1 12.0 0.6 0.11 11.9 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) PKHD_C PF18331.1 AIF83937.1 - 0.011 15.8 0.0 4.8 7.3 0.0 2.3 2 0 0 2 2 2 0 PKHD-type hydroxylase C-terminal domain DUF1811 PF08838.10 AIF83938.1 - 0.002 18.3 2.2 0.0023 18.2 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1811) Bap31_Bap29_C PF18035.1 AIF83938.1 - 0.0037 17.2 4.6 0.0054 16.7 4.6 1.2 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain GAS PF13851.6 AIF83938.1 - 0.0037 16.6 2.6 0.0039 16.6 2.6 1.0 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DivIC PF04977.15 AIF83938.1 - 0.011 15.5 1.9 0.013 15.3 1.9 1.1 1 0 0 1 1 1 0 Septum formation initiator DUF4140 PF13600.6 AIF83938.1 - 0.027 14.9 1.5 0.028 14.8 1.5 1.0 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Fib_alpha PF08702.10 AIF83938.1 - 0.028 14.6 0.7 0.03 14.5 0.7 1.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family BST2 PF16716.5 AIF83938.1 - 0.031 14.8 1.4 0.036 14.7 1.4 1.1 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 TPD52 PF04201.15 AIF83938.1 - 0.039 13.5 2.0 0.038 13.6 2.0 1.1 1 0 0 1 1 1 0 Tumour protein D52 family Med9 PF07544.13 AIF83938.1 - 0.041 14.0 3.0 0.052 13.6 3.0 1.2 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 CCDC-167 PF15188.6 AIF83938.1 - 0.063 13.6 4.4 0.067 13.5 4.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Atg14 PF10186.9 AIF83938.1 - 0.87 8.6 5.6 0.9 8.6 5.6 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prim-Pol PF09250.11 AIF83940.1 - 0.029 14.7 0.0 0.047 14.0 0.0 1.3 1 0 0 1 1 1 0 Bifunctional DNA primase/polymerase, N-terminal MRP-S23 PF10484.9 AIF83941.1 - 0.066 13.5 0.0 0.077 13.3 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S23 Tmemb_55A PF09788.9 AIF83942.1 - 0.0033 16.5 0.4 0.0037 16.4 0.4 1.0 1 0 0 1 1 1 1 Transmembrane protein 55A zf-LITAF-like PF10601.9 AIF83942.1 - 0.0046 17.2 0.2 0.025 14.8 0.0 1.9 2 0 0 2 2 2 1 LITAF-like zinc ribbon domain zinc_ribbon_5 PF13719.6 AIF83942.1 - 0.0092 15.7 0.9 0.56 10.0 0.1 2.1 2 0 0 2 2 2 1 zinc-ribbon domain UPF0547 PF10571.9 AIF83942.1 - 0.021 14.9 1.7 0.094 12.8 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-C3HC4_3 PF13920.6 AIF83942.1 - 0.028 14.3 0.5 0.039 13.8 0.5 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HypA PF01155.19 AIF83942.1 - 0.041 13.9 0.2 0.045 13.8 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cys_rich_KTR PF14205.6 AIF83942.1 - 0.047 13.5 0.8 2.1 8.2 0.1 2.1 2 0 0 2 2 2 0 Cysteine-rich KTR zf-RING_2 PF13639.6 AIF83942.1 - 0.051 13.9 1.4 0.069 13.5 1.4 1.2 1 0 0 1 1 1 0 Ring finger domain Mu-like_Com PF10122.9 AIF83942.1 - 0.18 11.3 2.5 0.32 10.5 2.5 1.6 1 1 0 1 1 1 0 Mu-like prophage protein Com DUF4781 PF16013.5 AIF83943.1 - 0.08 11.7 0.8 0.079 11.8 0.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) Phage_holin_3_6 PF07332.11 AIF83945.1 - 8e-05 22.6 2.0 8.8e-05 22.5 2.0 1.0 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III Spc7 PF08317.11 AIF83946.1 - 0.0048 15.8 0.5 0.012 14.5 0.5 1.7 1 0 0 1 1 1 1 Spc7 kinetochore protein COG5 PF10392.9 AIF83946.1 - 0.038 14.2 0.4 0.11 12.7 0.4 1.7 1 0 0 1 1 1 0 Golgi transport complex subunit 5 COMMD1_N PF17221.3 AIF83946.1 - 0.38 11.1 2.4 13 6.2 0.1 2.9 3 0 0 3 3 3 0 COMMD1 N-terminal domain KELK PF15796.5 AIF83946.1 - 9.4 6.8 7.0 7.9 7.0 0.1 3.4 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase zf-RRN7 PF11781.8 AIF83947.1 - 0.04 13.6 0.0 0.055 13.2 0.0 1.2 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 PLDc_2 PF13091.6 AIF83954.1 - 1.7e-19 70.0 0.1 2.6e-19 69.4 0.1 1.3 1 0 0 1 1 1 1 PLD-like domain PLDc PF00614.22 AIF83954.1 - 1.1e-06 28.5 0.0 7.7e-06 25.9 0.0 2.1 1 1 1 2 2 2 1 Phospholipase D Active site motif RE_NgoFVII PF09565.10 AIF83954.1 - 0.0049 16.2 0.1 0.006 15.9 0.1 1.2 1 0 0 1 1 1 1 NgoFVII restriction endonuclease AIM24 PF01987.17 AIF83955.1 - 2.6e-50 171.1 1.3 2.9e-50 170.9 1.3 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 PUA PF01472.20 AIF83956.1 - 7.8e-17 61.0 0.3 7.8e-17 61.0 0.3 1.5 2 0 0 2 2 2 1 PUA domain PUA_3 PF17785.1 AIF83956.1 - 0.098 12.5 0.0 0.39 10.6 0.0 2.0 1 1 0 1 1 1 0 PUA-like domain SH3_2 PF07653.17 AIF83956.1 - 0.11 12.2 0.3 0.26 11.0 0.0 1.8 2 1 0 2 2 2 0 Variant SH3 domain HTH_24 PF13412.6 AIF83957.1 - 6.4e-08 32.0 0.5 1.6e-07 30.7 0.5 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF83957.1 - 5.1e-05 23.0 0.6 0.00012 21.8 0.6 1.7 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_IclR PF09339.10 AIF83957.1 - 0.019 14.8 0.1 0.036 13.9 0.1 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_23 PF13384.6 AIF83957.1 - 0.029 14.2 0.0 0.076 12.8 0.0 1.8 1 1 0 1 1 1 0 Homeodomain-like domain HTH_20 PF12840.7 AIF83957.1 - 0.046 13.8 0.3 0.17 12.0 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_11 PF08279.12 AIF83957.1 - 0.05 13.5 0.2 1.4 9.0 0.0 2.6 2 0 0 2 2 2 0 HTH domain HTH_28 PF13518.6 AIF83957.1 - 0.074 13.2 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_8 PF02954.19 AIF83957.1 - 0.12 12.2 0.1 0.38 10.6 0.0 2.0 2 1 0 2 2 2 0 Bacterial regulatory protein, Fis family HTH_5 PF01022.20 AIF83957.1 - 0.12 12.2 0.1 0.33 10.8 0.1 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Proteasome PF00227.26 AIF83958.1 - 1.5e-49 168.1 0.1 1.8e-49 167.8 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit HATPase_c_3 PF13589.6 AIF83959.1 - 6e-13 48.8 0.0 1.2e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 AIF83959.1 - 0.079 13.5 0.0 0.24 11.9 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Copper-bind PF00127.20 AIF83960.1 - 3.6e-08 33.8 0.0 4.8e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF83960.1 - 2.4e-06 27.6 0.1 5e-06 26.6 0.1 1.5 1 1 0 1 1 1 1 Cupredoxin-like domain eRF1_2 PF03464.15 AIF83961.1 - 7.7e-36 123.3 0.0 2.8e-35 121.5 0.0 1.9 2 0 0 2 2 2 1 eRF1 domain 2 eRF1_3 PF03465.15 AIF83961.1 - 3.3e-18 66.2 0.3 7.8e-18 65.0 0.3 1.7 1 0 0 1 1 1 1 eRF1 domain 3 acVLRF1 PF18859.1 AIF83961.1 - 3.9e-15 56.3 0.0 6.9e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 AIF83961.1 - 9e-13 48.7 0.0 6.2e-12 45.9 0.0 2.3 2 1 1 3 3 3 1 Bacterial archaeo-eukaryotic release factor family 10 eRF1_1 PF03463.15 AIF83961.1 - 1.6e-10 41.1 0.0 2.7e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 Zn-ribbon_8 PF09723.10 AIF83961.1 - 0.0042 17.2 0.9 0.011 15.9 0.3 2.1 2 0 0 2 2 2 1 Zinc ribbon domain HypA PF01155.19 AIF83961.1 - 0.012 15.7 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA YrbL-PhoP_reg PF10707.9 AIF83961.1 - 0.1 12.1 0.2 0.34 10.4 0.0 2.0 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL CBS PF00571.28 AIF83962.1 - 5.3e-18 65.2 2.2 3.7e-12 46.5 0.1 2.3 2 0 0 2 2 2 2 CBS domain HTH_3 PF01381.22 AIF83962.1 - 9.9e-13 47.9 0.2 2e-12 47.0 0.1 1.5 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 AIF83962.1 - 3.8e-11 43.2 0.0 5.8e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 AIF83962.1 - 1.1e-09 38.2 0.7 1.6e-09 37.6 0.1 1.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_25 PF13413.6 AIF83962.1 - 0.00043 20.1 0.0 0.00071 19.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain CoA_binding_2 PF13380.6 AIF83962.1 - 0.0071 16.8 0.1 0.014 15.9 0.1 1.4 1 1 0 1 1 1 1 CoA binding domain MqsA_antitoxin PF15731.5 AIF83962.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.5 2 0 0 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA YdaS_antitoxin PF15943.5 AIF83962.1 - 0.087 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Gp_dh_N PF00044.24 AIF83964.1 - 6.1e-06 26.5 0.0 7e-05 23.1 0.0 2.5 3 0 0 3 3 3 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 AIF83964.1 - 2.1e-05 24.6 0.2 5e-05 23.4 0.2 1.7 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Gp_dh_C PF02800.20 AIF83964.1 - 0.0013 18.4 0.0 0.016 14.8 0.0 2.4 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain F420_oxidored PF03807.17 AIF83964.1 - 0.018 15.6 0.4 0.13 12.9 0.4 2.2 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 AIF83964.1 - 0.037 14.3 0.0 0.083 13.1 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_3 PF03447.16 AIF83964.1 - 0.066 13.9 0.1 0.15 12.7 0.1 1.6 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GATase PF00117.28 AIF83965.1 - 5.1e-53 179.7 0.0 6.3e-53 179.4 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIF83965.1 - 9.8e-11 41.8 0.2 3e-10 40.2 0.2 1.7 1 1 0 1 1 1 1 Peptidase C26 Glycos_transf_3 PF00591.21 AIF83966.1 - 2.6e-78 263.1 1.5 2.6e-78 263.1 1.5 1.4 2 0 0 2 2 2 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 AIF83966.1 - 9.1e-16 57.5 2.1 1.7e-15 56.6 2.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Ribosomal_L12_N PF16320.5 AIF83966.1 - 0.092 12.5 4.3 0.25 11.1 4.3 1.8 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain Rad51 PF08423.11 AIF83967.1 - 8e-86 287.4 0.0 1.1e-85 287.0 0.0 1.1 1 0 0 1 1 1 1 Rad51 ATPase PF06745.13 AIF83967.1 - 7.6e-11 41.8 0.3 3.4e-10 39.7 0.0 2.1 2 0 0 2 2 2 1 KaiC RecA PF00154.21 AIF83967.1 - 1.1e-10 41.4 0.1 1.8e-10 40.8 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 AIF83967.1 - 2.2e-09 37.8 0.3 6.3e-09 36.3 0.3 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF4332 PF14229.6 AIF83967.1 - 0.0017 18.6 0.1 0.0067 16.6 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4332) DNA_pol_lambd_f PF10391.9 AIF83967.1 - 0.0024 17.6 0.0 0.007 16.2 0.0 1.8 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda Cdd1 PF11731.8 AIF83967.1 - 0.004 17.3 0.0 0.0075 16.5 0.0 1.3 1 0 0 1 1 1 1 Pathogenicity locus HHH PF00633.23 AIF83967.1 - 0.026 14.4 0.0 0.061 13.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif AAA PF00004.29 AIF83967.1 - 0.069 13.6 0.0 0.31 11.5 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TfoX_C PF04994.13 AIF83967.1 - 0.079 13.1 0.0 0.23 11.6 0.0 1.8 1 0 0 1 1 1 0 TfoX C-terminal domain IMS_HHH PF11798.8 AIF83967.1 - 0.099 13.0 0.0 0.3 11.5 0.0 1.9 1 0 0 1 1 1 0 IMS family HHH motif UPF0184 PF03670.13 AIF83969.1 - 0.0025 18.1 4.3 0.49 10.8 0.1 3.4 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0184) DUF2408 PF10303.9 AIF83969.1 - 0.0079 16.8 6.2 0.0079 16.8 6.2 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF2408) TMPIT PF07851.13 AIF83969.1 - 0.013 14.8 1.0 0.013 14.8 1.0 2.1 2 0 0 2 2 2 0 TMPIT-like protein TolA_bind_tri PF16331.5 AIF83969.1 - 0.27 11.3 7.3 11 6.1 0.1 3.6 3 0 0 3 3 3 0 TolA binding protein trimerisation UPF0228 PF05727.11 AIF83969.1 - 0.37 10.6 6.5 0.53 10.1 0.4 3.0 1 1 1 3 3 3 0 Uncharacterised protein family (UPF0228) NPV_P10 PF05531.12 AIF83969.1 - 1.1 9.8 8.2 11 6.5 0.7 3.8 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 AIF83969.1 - 1.1 9.8 11.1 4.8 7.7 2.9 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 APG6_N PF17675.1 AIF83969.1 - 1.3 9.5 13.4 1.2e+02 3.2 13.4 2.4 1 1 0 1 1 1 0 Apg6 coiled-coil region FUSC PF04632.12 AIF83969.1 - 1.6 7.2 4.7 2.3 6.6 4.7 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1664 PF07889.12 AIF83969.1 - 2.7 8.1 13.3 1.7 8.7 2.1 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) IGPD PF00475.18 AIF83970.1 - 0.0083 16.4 0.0 0.0088 16.3 0.0 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Trp_syntA PF00290.20 AIF83971.1 - 3.2e-89 298.2 0.0 3.7e-89 298.0 0.0 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain His_biosynth PF00977.21 AIF83971.1 - 7.7e-07 28.8 0.0 1.3e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Histidine biosynthesis protein PcrB PF01884.17 AIF83971.1 - 4.7e-05 22.9 0.2 0.00054 19.5 0.1 2.1 2 0 0 2 2 2 1 PcrB family Ribul_P_3_epim PF00834.19 AIF83971.1 - 0.001 18.5 0.0 0.0023 17.4 0.0 1.6 2 0 0 2 2 2 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.14 AIF83971.1 - 0.008 15.5 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 AIF83971.1 - 0.013 14.5 0.0 0.26 10.3 0.0 2.0 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain NanE PF04131.14 AIF83971.1 - 0.017 14.4 0.2 0.051 12.8 0.0 1.9 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.21 AIF83971.1 - 0.098 11.8 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase Pterin_bind PF00809.22 AIF83971.1 - 0.13 11.9 0.3 3 7.4 0.0 2.6 3 0 0 3 3 3 0 Pterin binding enzyme PALP PF00291.25 AIF83972.1 - 8.2e-44 150.2 0.7 9.7e-44 149.9 0.7 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme IGPS PF00218.21 AIF83973.1 - 1.1e-65 221.4 0.6 1.2e-65 221.2 0.6 1.0 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase NanE PF04131.14 AIF83973.1 - 3e-05 23.3 1.2 8.4e-05 21.8 1.2 1.7 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase QRPTase_C PF01729.19 AIF83973.1 - 0.005 16.6 0.0 0.0094 15.7 0.0 1.4 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 AIF83973.1 - 0.0061 16.0 0.1 0.048 13.1 0.0 2.1 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 AIF83973.1 - 0.021 14.1 2.6 0.11 11.7 0.0 2.4 2 1 0 2 2 2 0 Thiazole biosynthesis protein ThiG FMN_dh PF01070.18 AIF83973.1 - 0.13 11.2 0.4 0.9 8.5 0.4 1.9 1 1 0 1 1 1 0 FMN-dependent dehydrogenase AAA_22 PF13401.6 AIF83974.1 - 5e-11 43.0 0.0 1.5e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIF83974.1 - 5.1e-08 33.5 0.1 3e-07 31.0 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 AIF83974.1 - 1.2e-05 25.7 0.0 3.3e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 AIF83974.1 - 1.8e-05 24.2 0.1 3.2e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Bacterial TniB protein TIP49_C PF17856.1 AIF83974.1 - 0.0017 18.4 3.3 0.013 15.6 0.0 3.1 3 1 1 4 4 4 1 TIP49 AAA-lid domain NB-ARC PF00931.22 AIF83974.1 - 0.0063 15.7 0.0 0.013 14.7 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_24 PF13479.6 AIF83974.1 - 0.017 14.9 1.2 0.081 12.6 0.8 2.3 2 1 0 2 2 2 0 AAA domain MarR_2 PF12802.7 AIF83974.1 - 0.017 15.0 0.4 0.15 12.0 0.1 2.4 2 0 0 2 2 2 0 MarR family SRP54 PF00448.22 AIF83974.1 - 0.025 14.2 0.8 0.058 13.0 0.8 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NACHT PF05729.12 AIF83974.1 - 0.061 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 AIF83974.1 - 0.065 13.1 2.9 0.089 12.7 0.7 2.3 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 AIF83974.1 - 0.073 12.8 0.8 0.36 10.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_assoc_2 PF16193.5 AIF83974.1 - 0.077 13.3 0.0 0.27 11.6 0.0 1.9 1 1 0 1 1 1 0 AAA C-terminal domain AAA_14 PF13173.6 AIF83974.1 - 0.078 13.0 1.6 0.37 10.8 1.6 2.1 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 AIF83974.1 - 0.094 12.6 0.7 3.1 7.7 0.4 2.5 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 AIF83974.1 - 0.11 12.8 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain HTH_IclR PF09339.10 AIF83975.1 - 0.087 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain TrmB PF01978.19 AIF83975.1 - 0.1 12.5 0.0 0.15 11.9 0.0 1.3 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB CTP_synth_N PF06418.14 AIF83979.1 - 4.1e-119 396.7 0.6 5.2e-119 396.4 0.6 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 AIF83979.1 - 4.3e-48 163.6 0.0 6.8e-48 163.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIF83979.1 - 3.4e-08 33.5 0.0 5.9e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 CbiA PF01656.23 AIF83979.1 - 0.0033 17.5 0.0 0.01 15.9 0.0 1.7 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain YmaF PF12788.7 AIF83979.1 - 0.12 12.9 0.3 0.27 11.8 0.3 1.6 1 0 0 1 1 1 0 YmaF family NAD_kinase PF01513.21 AIF83980.1 - 2.3e-34 118.9 0.2 3.1e-34 118.5 0.2 1.2 1 0 0 1 1 1 1 ATP-NAD kinase HTH_24 PF13412.6 AIF83980.1 - 0.00095 18.7 0.0 0.002 17.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 AIF83980.1 - 0.0017 18.2 0.0 0.0032 17.3 0.0 1.5 1 0 0 1 1 1 1 MarR family MarR PF01047.22 AIF83980.1 - 0.0023 17.8 0.2 0.0047 16.8 0.2 1.4 1 0 0 1 1 1 1 MarR family RNA_pol_Rpc34 PF05158.12 AIF83980.1 - 0.005 16.3 0.0 0.0069 15.8 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit HTH_27 PF13463.6 AIF83980.1 - 0.011 16.3 0.1 0.025 15.1 0.1 1.7 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_9 PF08221.11 AIF83980.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain TrmB PF01978.19 AIF83980.1 - 0.12 12.3 0.1 0.34 10.8 0.1 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB PfkB PF00294.24 AIF83981.1 - 5.1e-10 39.1 0.0 1.4e-09 37.7 0.0 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 AIF83981.1 - 0.016 14.6 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase DUF4224 PF13986.6 AIF83981.1 - 0.12 12.3 0.0 2.5 8.1 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4224) Ribosomal_S26e PF01283.19 AIF83982.1 - 2.5e-22 79.4 0.6 3e-22 79.1 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S26e zf-ribbon_3 PF13248.6 AIF83982.1 - 0.021 14.2 2.2 0.04 13.3 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain Lar_restr_allev PF14354.6 AIF83982.1 - 0.027 14.8 0.4 0.53 10.7 0.0 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar HlyD PF00529.20 AIF83982.1 - 0.046 13.6 0.0 0.062 13.2 0.0 1.2 1 0 0 1 1 1 0 HlyD membrane-fusion protein of T1SS zf-dskA_traR PF01258.17 AIF83982.1 - 0.055 13.4 0.6 3.5 7.6 0.0 2.3 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger Auto_anti-p27 PF06677.12 AIF83982.1 - 0.07 13.3 1.2 11 6.3 0.1 2.3 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) CDP-OH_P_transf PF01066.21 AIF83983.1 - 5.5e-10 39.9 1.0 5.5e-10 39.9 1.0 2.0 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase HTH_27 PF13463.6 AIF83984.1 - 0.018 15.5 0.0 0.024 15.1 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain Response_reg PF00072.24 AIF83985.1 - 1.3e-13 51.1 0.1 1.4e-08 34.9 0.0 2.2 1 1 0 2 2 2 2 Response regulator receiver domain Trimer_CC PF08954.11 AIF83985.1 - 0.1 12.2 0.6 4.8 6.8 0.0 2.5 2 0 0 2 2 2 0 Trimerisation motif HATPase_c PF02518.26 AIF83986.1 - 5.9e-24 84.7 0.1 9.8e-24 84.0 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MASE3 PF17159.4 AIF83986.1 - 6.1e-13 48.9 16.6 5.2e-09 36.1 2.8 2.2 2 0 0 2 2 2 2 Membrane-associated sensor domain HisKA PF00512.25 AIF83986.1 - 1.2e-12 47.7 0.2 5.2e-12 45.6 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain YtpI PF14007.6 AIF83986.1 - 0.031 14.4 0.3 0.031 14.4 0.3 3.2 3 1 1 4 4 4 0 YtpI-like protein adh_short_C2 PF13561.6 AIF83988.1 - 3.6e-55 187.1 0.1 4.2e-55 186.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 AIF83988.1 - 4.1e-44 150.4 0.3 4.9e-44 150.1 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AIF83988.1 - 1.2e-09 38.3 0.2 1.7e-09 37.9 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AIF83988.1 - 0.0014 18.1 0.3 0.0037 16.8 0.3 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 AIF83988.1 - 0.028 13.7 0.1 0.055 12.8 0.1 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain POR PF01558.18 AIF83988.1 - 0.044 13.8 1.6 0.14 12.2 1.6 1.8 1 1 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase RmlD_sub_bind PF04321.17 AIF83988.1 - 0.071 12.2 1.1 0.63 9.1 0.8 2.2 1 1 0 1 1 1 0 RmlD substrate binding domain CbtA PF09490.10 AIF83989.1 - 0.64 9.8 12.2 0.23 11.2 0.4 2.5 2 1 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) MarR_2 PF12802.7 AIF83990.1 - 7.3e-12 45.0 0.1 1.1e-11 44.5 0.1 1.2 1 0 0 1 1 1 1 MarR family MarR PF01047.22 AIF83990.1 - 7.5e-12 45.0 0.0 1.2e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 AIF83990.1 - 0.00015 22.2 0.0 0.00027 21.3 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_IclR PF09339.10 AIF83990.1 - 0.00074 19.3 0.1 0.0013 18.5 0.1 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.6 AIF83990.1 - 0.0013 18.2 0.0 0.0028 17.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding FGase PF05013.12 AIF83990.1 - 0.018 15.3 0.8 0.1 12.8 0.0 2.0 1 1 1 2 2 2 0 N-formylglutamate amidohydrolase Binary_toxB PF03495.14 AIF83990.1 - 0.02 15.1 0.0 0.03 14.5 0.0 1.2 1 0 0 1 1 1 0 Clostridial binary toxin B/anthrax toxin PA Ca-binding domain TrmB PF01978.19 AIF83990.1 - 0.025 14.5 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 AIF83990.1 - 0.026 14.4 0.0 0.08 12.9 0.0 1.8 1 0 0 1 1 1 0 HTH domain HTH_Crp_2 PF13545.6 AIF83990.1 - 0.035 14.1 0.1 0.39 10.7 0.0 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain PDDEXK_1 PF12705.7 AIF83990.1 - 0.069 13.1 0.0 0.15 11.9 0.0 1.6 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily GSDH PF07995.11 AIF83991.1 - 9.2e-46 156.7 0.3 1.1e-45 156.4 0.3 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Aldolase_II PF00596.21 AIF83992.1 - 9.7e-42 143.0 0.7 1.1e-41 142.8 0.7 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain ATP-synt_F PF01990.17 AIF83993.1 - 1.3e-15 57.4 0.1 1.4e-15 57.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit SIT PF15330.6 AIF83995.1 - 0.034 14.6 0.1 0.037 14.5 0.1 1.0 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Phage_pRha PF09669.10 AIF83995.1 - 0.12 12.9 0.3 0.14 12.7 0.3 1.0 1 0 0 1 1 1 0 Phage regulatory protein Rha (Phage_pRha) SnoaL PF07366.12 AIF83996.1 - 1.5e-35 121.8 0.0 1.7e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 AIF83996.1 - 3.2e-19 69.5 0.0 4e-19 69.1 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIF83996.1 - 0.059 13.8 0.0 0.085 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Peptidase_U4 PF03419.13 AIF83999.1 - 0.0055 16.0 0.3 0.0063 15.8 0.3 1.0 1 0 0 1 1 1 1 Sporulation factor SpoIIGA PrgI PF12666.7 AIF83999.1 - 0.008 16.9 0.2 0.0086 16.8 0.2 1.1 1 0 0 1 1 1 1 PrgI family protein MWFE PF15879.5 AIF83999.1 - 0.015 15.4 0.9 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit DnaJ PF00226.31 AIF84000.1 - 2.7e-27 94.7 3.5 3.7e-27 94.2 0.8 2.0 2 0 0 2 2 2 1 DnaJ domain DUF1764 PF08576.10 AIF84000.1 - 0.025 15.5 0.4 0.036 15.0 0.4 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF3776 PF12618.8 AIF84000.1 - 0.069 13.7 0.9 0.1 13.2 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3776) CPBP PF02517.16 AIF84001.1 - 0.028 14.8 14.3 0.16 12.4 10.5 2.8 1 1 1 2 2 2 0 CPBP intramembrane metalloprotease Polyketide_cyc2 PF10604.9 AIF84002.1 - 1.8e-13 51.0 0.2 2e-13 50.8 0.2 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.11 AIF84002.1 - 1.6e-07 31.6 0.1 1.9e-07 31.3 0.1 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc PF03364.20 AIF84002.1 - 3.9e-05 23.8 0.2 4.8e-05 23.6 0.2 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF4920 PF16267.5 AIF84003.1 - 0.11 12.5 0.0 14 5.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4920) Collectrin PF16959.5 AIF84004.1 - 0.1 12.4 1.1 0.11 12.2 1.1 1.1 1 0 0 1 1 1 0 Renal amino acid transporter APG6_N PF17675.1 AIF84005.1 - 2e-08 34.9 17.4 0.00028 21.4 2.8 2.1 2 0 0 2 2 2 2 Apg6 coiled-coil region YabA PF06156.13 AIF84005.1 - 1.2e-05 25.9 10.2 0.0078 16.8 1.0 2.6 1 1 2 3 3 3 2 Initiation control protein YabA ADIP PF11559.8 AIF84005.1 - 1.5e-05 25.1 11.0 0.0011 19.0 0.6 2.1 2 0 0 2 2 2 2 Afadin- and alpha -actinin-Binding HALZ PF02183.18 AIF84005.1 - 2.6e-05 24.4 14.9 0.52 10.6 0.3 4.5 4 1 0 4 4 4 2 Homeobox associated leucine zipper TMF_TATA_bd PF12325.8 AIF84005.1 - 5.6e-05 23.3 14.0 0.013 15.7 3.3 2.1 1 1 1 2 2 2 2 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 AIF84005.1 - 6.8e-05 22.8 17.4 0.0022 17.9 1.8 3.0 2 1 1 3 3 3 2 TATA element modulatory factor 1 DNA binding ZapB PF06005.12 AIF84005.1 - 0.00012 22.4 18.7 0.027 14.9 5.2 3.4 2 1 1 3 3 3 2 Cell division protein ZapB GAS PF13851.6 AIF84005.1 - 0.00023 20.6 16.2 0.00042 19.7 7.8 2.2 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding DUF2046 PF09755.9 AIF84005.1 - 0.00026 20.3 8.2 0.0021 17.3 2.5 2.3 1 1 1 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) Csm1_N PF18504.1 AIF84005.1 - 0.00081 19.7 14.2 0.00092 19.5 1.3 3.4 2 2 2 4 4 4 1 Csm1 N-terminal domain DUF848 PF05852.11 AIF84005.1 - 0.00085 19.4 7.6 0.0029 17.7 1.2 2.2 2 0 0 2 2 2 1 Gammaherpesvirus protein of unknown function (DUF848) KASH_CCD PF14662.6 AIF84005.1 - 0.0009 19.1 13.0 0.0056 16.5 2.4 2.7 2 1 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH CtIP_N PF10482.9 AIF84005.1 - 0.0012 18.8 9.0 0.035 14.2 4.3 2.8 1 1 0 2 2 2 1 Tumour-suppressor protein CtIP N-terminal domain Mod_r PF07200.13 AIF84005.1 - 0.002 18.3 16.8 0.0062 16.6 4.8 2.1 1 1 1 2 2 2 1 Modifier of rudimentary (Mod(r)) protein DivIC PF04977.15 AIF84005.1 - 0.0021 17.8 20.8 0.23 11.2 6.1 3.4 2 2 1 3 3 3 1 Septum formation initiator ATG16 PF08614.11 AIF84005.1 - 0.0021 18.3 22.5 0.084 13.1 19.9 2.1 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) TcdA_TcdB PF12919.7 AIF84005.1 - 0.0022 17.3 1.8 0.0028 17.0 1.8 1.0 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain bZIP_1 PF00170.21 AIF84005.1 - 0.0031 17.6 15.2 0.14 12.3 4.8 3.8 2 2 0 3 3 3 2 bZIP transcription factor CENP-H PF05837.12 AIF84005.1 - 0.0043 17.4 18.5 0.16 12.4 4.3 2.2 2 0 0 2 2 2 2 Centromere protein H (CENP-H) CENP-F_leu_zip PF10473.9 AIF84005.1 - 0.0046 17.0 9.4 0.16 12.0 0.7 2.2 2 0 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4686 PF15742.5 AIF84005.1 - 0.005 16.0 7.5 0.27 10.3 1.5 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4686) Cep57_CLD_2 PF14197.6 AIF84005.1 - 0.0052 16.8 17.1 0.019 15.0 2.6 3.3 2 1 1 3 3 3 1 Centrosome localisation domain of PPC89 DUF4795 PF16043.5 AIF84005.1 - 0.0065 16.1 9.3 0.23 11.0 1.4 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4795) DUF4201 PF13870.6 AIF84005.1 - 0.0067 16.2 11.2 0.18 11.5 1.5 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) Takusan PF04822.13 AIF84005.1 - 0.0075 16.1 2.0 0.089 12.7 0.1 2.6 2 1 0 2 2 2 1 Takusan DUF2353 PF09789.9 AIF84005.1 - 0.0089 15.4 5.2 0.014 14.8 5.2 1.3 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) PRKG1_interact PF15898.5 AIF84005.1 - 0.0098 16.8 11.1 0.056 14.3 3.0 2.3 2 0 0 2 2 2 1 cGMP-dependent protein kinase interacting domain Spc7 PF08317.11 AIF84005.1 - 0.014 14.3 13.0 0.22 10.4 2.6 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein PI_PP_I PF18363.1 AIF84005.1 - 0.03 14.5 0.5 1.7 8.9 0.0 2.3 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain FlaC_arch PF05377.11 AIF84005.1 - 0.039 14.3 5.3 1 9.8 2.2 3.4 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) Syntaxin PF00804.25 AIF84005.1 - 0.043 13.5 11.0 0.16 11.6 2.3 2.1 1 1 1 2 2 2 0 Syntaxin TSC22 PF01166.18 AIF84005.1 - 0.053 13.8 7.4 17 5.8 2.3 4.0 2 2 1 3 3 3 0 TSC-22/dip/bun family BST2 PF16716.5 AIF84005.1 - 0.071 13.7 18.7 1.4 9.5 2.5 3.1 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 NYD-SP28_assoc PF14775.6 AIF84005.1 - 0.083 13.0 9.6 13 6.0 0.2 4.1 3 1 1 4 4 4 0 Sperm tail C-terminal domain TolA_bind_tri PF16331.5 AIF84005.1 - 0.092 12.8 7.7 0.3 11.2 1.6 3.2 2 2 0 2 2 2 0 TolA binding protein trimerisation Fungal_TACC PF12709.7 AIF84005.1 - 0.097 13.1 9.4 6 7.4 0.2 3.3 2 2 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Wtap PF17098.5 AIF84005.1 - 0.099 12.6 17.9 0.19 11.6 3.6 3.2 3 1 1 4 4 3 0 WTAP/Mum2p family DUF3037 PF11236.8 AIF84005.1 - 0.13 12.7 2.4 18 5.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3037) Phage_GP20 PF06810.11 AIF84005.1 - 0.14 12.0 14.0 0.061 13.1 2.3 2.9 2 1 1 3 3 3 0 Phage minor structural protein GP20 DUF4472 PF14739.6 AIF84005.1 - 0.14 12.9 16.0 0.5 11.1 4.1 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4472) HMMR_C PF15908.5 AIF84005.1 - 0.14 12.4 10.6 1.3 9.2 1.0 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal Fib_alpha PF08702.10 AIF84005.1 - 0.14 12.3 8.1 1.4 9.1 0.5 2.1 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family CEP63 PF17045.5 AIF84005.1 - 0.15 12.0 10.9 0.63 9.9 3.1 2.2 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa GIT_CC PF16559.5 AIF84005.1 - 0.16 11.8 14.1 0.51 10.2 1.4 4.0 2 2 2 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor YlqD PF11068.8 AIF84005.1 - 0.18 12.2 12.1 1.3 9.4 2.5 2.1 2 0 0 2 2 2 0 YlqD protein bZIP_2 PF07716.15 AIF84005.1 - 0.2 11.7 21.7 0.56 10.3 0.8 4.6 2 2 2 4 4 4 0 Basic region leucine zipper UPF0242 PF06785.11 AIF84005.1 - 0.21 11.7 13.0 2.1 8.4 1.6 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TPR_MLP1_2 PF07926.12 AIF84005.1 - 0.25 11.4 26.3 0.27 11.3 8.0 2.9 2 2 0 2 2 2 0 TPR/MLP1/MLP2-like protein HAP1_N PF04849.13 AIF84005.1 - 0.27 10.4 15.1 5.2 6.2 5.2 2.6 1 1 1 2 2 2 0 HAP1 N-terminal conserved region IFT57 PF10498.9 AIF84005.1 - 0.28 10.1 9.5 0.15 11.0 5.0 1.9 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Leu_zip PF15294.6 AIF84005.1 - 0.44 10.0 10.9 0.68 9.4 4.8 2.2 1 1 1 2 2 2 0 Leucine zipper Cor1 PF04803.12 AIF84005.1 - 0.45 10.7 7.2 0.38 11.0 3.3 2.2 1 1 1 2 2 2 0 Cor1/Xlr/Xmr conserved region DUF3450 PF11932.8 AIF84005.1 - 0.45 9.8 23.7 1 8.6 5.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Cnn_1N PF07989.11 AIF84005.1 - 0.47 10.7 11.7 1.9 8.7 0.5 3.2 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 FliL PF03748.14 AIF84005.1 - 0.48 11.0 4.4 3.9 8.1 4.4 2.6 1 1 0 1 1 1 0 Flagellar basal body-associated protein FliL Ax_dynein_light PF10211.9 AIF84005.1 - 0.87 9.5 10.6 2.3 8.1 0.8 2.2 2 0 0 2 2 2 0 Axonemal dynein light chain Tup_N PF08581.10 AIF84005.1 - 0.96 9.8 8.6 5.8 7.3 3.7 2.7 2 1 0 2 2 2 0 Tup N-terminal Seryl_tRNA_N PF02403.22 AIF84005.1 - 0.96 9.7 14.9 3.1 8.1 6.1 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain THOC7 PF05615.13 AIF84005.1 - 1.1 9.5 13.3 2.1 8.6 3.7 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 DUF2408 PF10303.9 AIF84005.1 - 1.3 9.6 7.0 0.6 10.7 3.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Uso1_p115_C PF04871.13 AIF84005.1 - 1.3 9.4 24.5 0.56 10.6 8.4 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4515 PF14988.6 AIF84005.1 - 1.4 8.7 13.0 2.5 7.9 5.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4515) Fez1 PF06818.15 AIF84005.1 - 1.5 9.2 13.0 6.4 7.2 13.0 1.8 1 1 0 1 1 1 0 Fez1 Phage_lysis PF03245.13 AIF84005.1 - 1.6 8.9 13.2 2.8 8.1 12.9 1.6 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein DivIVA PF05103.13 AIF84005.1 - 2 8.5 15.7 2.4 8.2 3.7 2.3 1 1 1 2 2 2 0 DivIVA protein DUF724 PF05266.14 AIF84005.1 - 2 8.2 13.8 1.6 8.5 7.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Rootletin PF15035.6 AIF84005.1 - 2.4 8.2 14.8 27 4.7 3.7 2.4 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion FapA PF03961.13 AIF84005.1 - 2.4 6.7 6.8 8.8 4.8 7.0 1.7 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF1664 PF07889.12 AIF84005.1 - 2.5 8.2 6.3 16 5.6 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CENP-Q PF13094.6 AIF84005.1 - 2.6 8.2 18.9 0.75 10.0 3.8 3.0 1 1 2 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4358 PF14270.6 AIF84005.1 - 3.3 8.0 6.3 18 5.7 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4358) SlyX PF04102.12 AIF84005.1 - 3.6 8.3 13.7 6.6 7.4 1.1 3.9 2 2 2 4 4 4 0 SlyX DUF1640 PF07798.11 AIF84005.1 - 3.8 7.5 14.8 2.2e+02 1.8 14.8 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) Bap31_Bap29_C PF18035.1 AIF84005.1 - 4.6 7.3 16.9 0.7 9.9 0.2 4.0 2 1 2 4 4 4 0 Bap31/Bap29 cytoplasmic coiled-coil domain Atg14 PF10186.9 AIF84005.1 - 5.5 6.0 10.1 5.2 6.0 1.7 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_13 PF13166.6 AIF84005.1 - 6 5.4 14.6 59 2.1 14.7 1.8 1 1 0 1 1 1 0 AAA domain Med21 PF11221.8 AIF84005.1 - 6.1 7.1 15.9 0.16 12.2 0.8 2.8 1 1 0 2 2 2 0 Subunit 21 of Mediator complex COG2 PF06148.11 AIF84005.1 - 7.4 6.7 8.2 16 5.6 0.6 2.4 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Zn_ribbon_17 PF17120.5 AIF84006.1 - 0.011 15.3 2.0 0.014 15.0 2.0 1.2 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHF5 PF03660.14 AIF84006.1 - 0.018 15.2 1.0 0.021 15.0 1.0 1.2 1 0 0 1 1 1 0 PHF5-like protein Prok-RING_1 PF14446.6 AIF84006.1 - 0.04 13.8 2.6 0.058 13.3 2.6 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD PF00628.29 AIF84006.1 - 0.07 13.0 4.6 0.094 12.6 4.6 1.2 1 0 0 1 1 1 0 PHD-finger PDH PF02153.17 AIF84007.1 - 4.1e-18 65.3 0.7 5.7e-18 64.9 0.7 1.1 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.15 AIF84007.1 - 2.2e-07 31.2 0.1 4e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 AIF84007.1 - 1.6e-05 25.4 0.5 0.00094 19.7 0.2 2.8 1 1 1 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent CoA_binding PF02629.19 AIF84007.1 - 0.00013 22.6 0.6 0.0005 20.7 0.1 2.0 2 0 0 2 2 2 1 CoA binding domain NAD_Gly3P_dh_N PF01210.23 AIF84007.1 - 0.00033 20.7 0.1 0.00062 19.8 0.1 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus CoA_binding_2 PF13380.6 AIF84007.1 - 0.0017 18.8 0.4 0.005 17.3 0.3 1.8 1 1 0 1 1 1 1 CoA binding domain Rossmann-like PF10727.9 AIF84007.1 - 0.0027 17.6 0.4 0.006 16.4 0.4 1.7 1 1 0 1 1 1 1 Rossmann-like domain IlvN PF07991.12 AIF84007.1 - 0.029 13.9 0.1 0.082 12.5 0.0 1.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DapB_N PF01113.20 AIF84007.1 - 0.041 14.0 0.0 0.11 12.6 0.0 1.9 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DpaA_N PF16924.5 AIF84007.1 - 0.042 13.9 0.1 0.3 11.2 0.0 2.4 3 1 1 4 4 4 0 Dipicolinate synthase subunit A N-terminal domain NmrA PF05368.13 AIF84007.1 - 0.046 13.3 0.3 1.4 8.4 0.3 2.3 1 1 0 1 1 1 0 NmrA-like family NAD_binding_10 PF13460.6 AIF84007.1 - 0.078 12.9 0.2 0.25 11.2 0.2 1.9 1 1 0 1 1 1 0 NAD(P)H-binding GFO_IDH_MocA PF01408.22 AIF84007.1 - 0.14 13.0 1.0 0.66 10.8 0.4 2.4 2 2 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 AIF84007.1 - 0.16 12.4 0.3 4.9 7.6 0.3 2.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain ApbA PF02558.16 AIF84007.1 - 0.42 10.2 1.5 4.7 6.9 0.3 2.6 2 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Aminotran_1_2 PF00155.21 AIF84008.1 - 5.3e-54 183.8 0.0 6.8e-54 183.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AIF84008.1 - 5.3e-10 38.8 0.0 8.2e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 AIF84008.1 - 2.9e-09 35.9 0.0 4.1e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme CM_2 PF01817.21 AIF84008.1 - 5.5e-08 33.0 2.1 5.5e-08 33.0 2.1 1.9 2 0 0 2 2 2 1 Chorismate mutase type II Beta_elim_lyase PF01212.21 AIF84008.1 - 3.6e-07 29.8 0.0 6.8e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 AIF84008.1 - 9.1e-05 21.9 0.0 0.00017 21.1 0.0 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SurA_N PF09312.11 AIF84008.1 - 0.02 14.9 1.2 0.16 12.1 0.6 2.4 2 0 0 2 2 2 0 SurA N-terminal domain Chorismate_synt PF01264.21 AIF84009.1 - 1.7e-136 454.2 0.0 2e-136 454.0 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Hva1_TUDOR PF11160.8 AIF84009.1 - 0.042 14.0 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 Hypervirulence associated proteins TUDOR domain EPSP_synthase PF00275.20 AIF84010.1 - 3.4e-108 362.0 0.4 4.1e-108 361.8 0.4 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) GHMP_kinases_N PF00288.26 AIF84011.1 - 1.4e-10 41.2 0.6 1.4e-10 41.2 0.6 2.3 3 0 0 3 3 3 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AIF84011.1 - 4.3e-06 27.0 0.1 1.7e-05 25.1 0.1 2.0 2 0 0 2 2 2 1 GHMP kinases C terminal Shikimate_dh_N PF08501.11 AIF84012.1 - 3.5e-30 104.1 0.0 6.6e-30 103.2 0.0 1.5 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 AIF84012.1 - 4.9e-14 51.8 1.6 1.5e-13 50.3 0.1 2.4 3 0 0 3 3 3 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 AIF84012.1 - 2.8e-08 33.9 0.1 5.8e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 AIF84012.1 - 0.00016 21.9 0.6 0.00028 21.2 0.6 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 AIF84012.1 - 0.00067 20.2 1.2 0.0017 18.9 1.2 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GARS_N PF02844.15 AIF84012.1 - 0.0019 19.0 0.4 0.0046 17.7 0.2 1.8 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain OCD_Mu_crystall PF02423.15 AIF84012.1 - 0.0027 16.7 0.1 0.0035 16.3 0.1 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family PglD_N PF17836.1 AIF84012.1 - 0.073 13.7 0.1 0.47 11.1 0.1 2.3 2 0 0 2 2 2 0 PglD N-terminal domain DHquinase_I PF01487.15 AIF84013.1 - 3.8e-51 174.6 0.1 4.2e-51 174.4 0.1 1.0 1 0 0 1 1 1 1 Type I 3-dehydroquinase DUF3268 PF11672.8 AIF84015.1 - 0.049 14.0 0.2 0.077 13.3 0.1 1.4 2 0 0 2 2 2 0 zinc-finger-containing domain N6_N4_Mtase PF01555.18 AIF84016.1 - 6.5e-34 117.6 0.0 7.9e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 DNA methylase Methyltransf_31 PF13847.6 AIF84016.1 - 2.9e-05 23.9 0.0 0.00036 20.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF84016.1 - 7e-05 23.4 0.0 0.01 16.5 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF84016.1 - 0.00081 20.1 0.0 0.0032 18.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 AIF84016.1 - 0.081 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MethyltransfD12 PF02086.15 AIF84016.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase DHQS PF01959.16 AIF84017.1 - 6.8e-107 357.4 1.2 8.1e-107 357.2 1.2 1.0 1 0 0 1 1 1 1 3-dehydroquinate synthase II Toprim PF01751.22 AIF84017.1 - 0.016 15.4 0.2 0.032 14.5 0.2 1.5 1 0 0 1 1 1 0 Toprim domain MotY_N PF18393.1 AIF84017.1 - 0.02 15.1 0.0 0.26 11.4 0.0 2.1 2 0 0 2 2 2 0 MotY N-terminal domain Helicase_RecD PF05127.14 AIF84017.1 - 0.021 14.7 0.0 0.044 13.6 0.0 1.4 1 0 0 1 1 1 0 Helicase DeoC PF01791.9 AIF84018.1 - 7.3e-49 166.5 0.0 8.5e-49 166.3 0.0 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase ThiG PF05690.14 AIF84018.1 - 0.003 16.9 4.0 0.01 15.2 0.6 2.9 3 1 0 3 3 3 1 Thiazole biosynthesis protein ThiG PEP_mutase PF13714.6 AIF84018.1 - 0.0039 16.7 0.2 0.11 12.0 0.1 2.1 1 1 1 2 2 2 1 Phosphoenolpyruvate phosphomutase His_biosynth PF00977.21 AIF84018.1 - 0.057 12.9 0.1 0.3 10.5 0.1 2.0 2 0 0 2 2 2 0 Histidine biosynthesis protein DUF561 PF04481.12 AIF84018.1 - 0.096 11.8 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF561) V4R PF02830.18 AIF84019.1 - 1.2e-10 41.2 1.1 1.9e-10 40.6 1.1 1.3 1 0 0 1 1 1 1 V4R domain AP_endonuc_2 PF01261.24 AIF84021.1 - 3.2e-32 111.7 0.0 3.9e-32 111.4 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF5397 PF17375.2 AIF84021.1 - 0.12 12.1 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5397) DNA_primase_lrg PF04104.14 AIF84022.1 - 1.6e-28 99.8 0.1 3.2e-28 98.9 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit DUF2067 PF09840.9 AIF84022.1 - 0.068 12.7 0.0 0.24 10.9 0.0 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) DNA_primase_S PF01896.19 AIF84023.1 - 6.2e-14 52.4 0.0 2.7e-13 50.3 0.0 2.0 2 1 0 2 2 2 1 DNA primase small subunit FAM72 PF14976.6 AIF84023.1 - 0.014 15.5 0.3 0.026 14.6 0.3 1.4 1 0 0 1 1 1 0 FAM72 protein Zn-ribbon_8 PF09723.10 AIF84023.1 - 0.018 15.2 0.7 0.038 14.1 0.7 1.6 1 0 0 1 1 1 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 AIF84023.1 - 0.036 13.6 0.5 0.095 12.2 0.5 1.8 1 0 0 1 1 1 0 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 AIF84023.1 - 0.039 13.9 0.7 0.099 12.6 0.7 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Ribosomal_L37ae PF01780.19 AIF84023.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Ribosomal L37ae protein family NOB1_Zn_bind PF08772.11 AIF84023.1 - 0.23 11.7 2.2 15 5.8 0.0 2.6 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like DUF4503 PF14951.6 AIF84023.1 - 0.3 9.5 1.6 0.46 8.9 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) Rubredoxin_2 PF18073.1 AIF84023.1 - 0.38 10.5 1.8 9.8 6.0 0.2 2.5 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf-ribbon_3 PF13248.6 AIF84023.1 - 1.4 8.4 8.8 9.5 5.8 3.1 2.6 2 0 0 2 2 2 0 zinc-ribbon domain UPF0182 PF03699.13 AIF84024.1 - 4.4e-40 137.6 3.3 4.4e-40 137.6 3.3 2.7 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0182) Wzy_C PF04932.15 AIF84024.1 - 0.083 12.5 1.9 0.3 10.7 0.1 2.7 3 0 0 3 3 3 0 O-Antigen ligase GATase PF00117.28 AIF84025.1 - 8.7e-22 77.8 0.0 1.1e-21 77.5 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIF84025.1 - 3.5e-11 43.3 0.0 1.9e-10 40.9 0.0 1.9 1 1 0 1 1 1 1 Peptidase C26 GATase_3 PF07685.14 AIF84025.1 - 0.033 13.8 0.1 0.043 13.4 0.1 1.5 1 1 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain TPR_1 PF00515.28 AIF84026.1 - 2.4e-14 52.4 13.9 4.3e-07 29.5 1.9 5.0 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 AIF84026.1 - 2.1e-13 49.2 11.6 6e-05 22.9 1.1 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.6 AIF84026.1 - 3.7e-13 49.9 9.3 9e-07 29.4 0.1 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 AIF84026.1 - 1.6e-11 43.4 8.3 6.3e-05 22.9 0.5 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 AIF84026.1 - 3.7e-11 42.5 13.2 3.4e-06 26.6 0.6 3.8 2 1 2 4 4 4 2 TPR repeat TPR_9 PF13371.6 AIF84026.1 - 5.2e-11 42.5 0.5 1.5e-08 34.6 0.0 3.0 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 AIF84026.1 - 7.6e-10 39.2 7.1 0.00067 20.1 0.2 3.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 AIF84026.1 - 2.1e-09 37.1 12.6 0.00029 21.0 1.4 4.0 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 AIF84026.1 - 2.4e-09 37.2 5.0 0.008 16.9 0.9 4.4 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 AIF84026.1 - 7.8e-05 22.9 11.1 8.7e-05 22.7 1.5 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 AIF84026.1 - 0.00014 21.6 5.3 0.66 10.1 0.0 4.2 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 AIF84026.1 - 0.00073 18.8 0.4 0.0013 18.0 0.4 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 AIF84026.1 - 0.00081 19.9 7.7 3.1 8.6 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat Peptidase_C39_2 PF13529.6 AIF84026.1 - 0.002 18.7 0.0 0.0053 17.3 0.0 1.8 1 0 0 1 1 1 1 Peptidase_C39 like family TPR_20 PF14561.6 AIF84026.1 - 0.003 17.8 5.6 0.054 13.8 0.4 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AIF84026.1 - 0.041 14.1 3.5 4.6 7.5 0.1 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.10 AIF84026.1 - 0.15 11.1 0.1 1.2 8.1 0.1 2.0 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) ABM PF03992.16 AIF84027.1 - 3.4e-15 55.9 0.0 5e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Aldo_ket_red PF00248.21 AIF84028.1 - 5.4e-24 84.9 0.5 1.3e-21 77.1 0.5 2.5 1 1 0 1 1 1 1 Aldo/keto reductase family HTH_45 PF14947.6 AIF84030.1 - 1.6e-07 31.2 0.0 1.8e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix Rio2_N PF09202.11 AIF84030.1 - 0.029 14.6 0.0 0.031 14.5 0.0 1.2 1 0 0 1 1 1 0 Rio2, N-terminal AAA_assoc_C PF09821.9 AIF84030.1 - 0.036 14.6 0.0 0.043 14.4 0.0 1.2 1 0 0 1 1 1 0 C-terminal AAA-associated domain UbiA PF01040.18 AIF84031.1 - 1e-29 103.6 19.5 1.4e-29 103.2 19.5 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family AsnC_trans_reg PF01037.21 AIF84032.1 - 1.2e-09 37.9 0.0 1.4e-09 37.8 0.0 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain DUF2203 PF09969.9 AIF84033.1 - 4.1e-36 124.4 0.0 4.7e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2203) HTH_44 PF14641.6 AIF84033.1 - 0.081 13.4 0.0 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix DNA-binding domain of SPT6 Na_H_Exchanger PF00999.21 AIF84034.1 - 4.1e-62 210.2 49.5 5.1e-62 209.9 49.5 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family GDE_C PF06202.14 AIF84035.1 - 3.9e-36 124.8 0.3 7e-36 124.0 0.1 1.5 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase Bac_rhamnosid6H PF17389.2 AIF84035.1 - 1.7e-10 40.7 0.0 2.8e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydro_100 PF12899.7 AIF84035.1 - 2.5e-08 33.0 0.1 0.001 17.8 0.0 2.2 2 0 0 2 2 2 2 Alkaline and neutral invertase Trehalase PF01204.18 AIF84035.1 - 2e-05 23.7 0.1 5e-05 22.3 0.0 1.6 2 0 0 2 2 2 1 Trehalase Glyco_hydro_36 PF17167.4 AIF84035.1 - 0.00042 19.1 0.0 0.0011 17.7 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain DUF608 PF04685.13 AIF84035.1 - 0.00067 18.9 0.1 0.0031 16.7 0.1 2.0 3 0 0 3 3 3 1 Glycosyl-hydrolase family 116, catalytic region Type_III_YscG PF09477.10 AIF84035.1 - 0.01 15.9 0.1 0.038 14.0 0.0 2.0 2 0 0 2 2 2 0 Bacterial type II secretion system chaperone protein (type_III_yscG) Fis1_TPR_C PF14853.6 AIF84035.1 - 0.11 12.6 0.1 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Osmo_MPGsynth PF09488.10 AIF84036.1 - 2e-145 484.4 0.0 2.3e-145 484.2 0.0 1.0 1 0 0 1 1 1 1 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) zf-C4_Topoisom PF01396.19 AIF84037.1 - 0.011 15.5 1.1 0.019 14.8 1.1 1.4 1 0 0 1 1 1 0 Topoisomerase DNA binding C4 zinc finger Zn_Tnp_IS1595 PF12760.7 AIF84037.1 - 0.033 14.2 0.3 0.053 13.5 0.3 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.12 AIF84037.1 - 0.051 13.1 5.3 0.051 13.1 5.3 1.7 2 0 0 2 2 2 0 TFIIB zinc-binding CEBP_ZZ PF16366.5 AIF84037.1 - 0.068 13.4 2.9 0.096 12.9 2.9 1.2 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain DnaJ_CXXCXGXG PF00684.19 AIF84037.1 - 0.073 13.4 1.0 0.12 12.8 1.0 1.4 1 1 0 1 1 1 0 DnaJ central domain A2L_zn_ribbon PF08792.10 AIF84037.1 - 0.2 11.4 4.6 0.38 10.5 4.6 1.5 1 1 0 1 1 1 0 A2L zinc ribbon domain C1_2 PF03107.16 AIF84037.1 - 0.32 11.4 6.6 0.57 10.5 6.6 1.5 1 1 0 1 1 1 0 C1 domain zf_UBZ PF18439.1 AIF84037.1 - 0.47 10.1 4.2 10 5.8 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger UPF0086 PF01868.16 AIF84038.1 - 0.026 14.4 0.1 0.74 9.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function UPF0086 HCBP_related PF06594.11 AIF84038.1 - 0.11 12.5 0.2 1.8 8.5 0.1 2.3 2 0 0 2 2 2 0 Haemolysin-type calcium binding protein related domain DUF4147 PF13660.6 AIF84039.1 - 1.3e-78 263.8 2.0 1.9e-78 263.2 1.5 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4147) MOFRL PF05161.13 AIF84039.1 - 2.4e-31 108.2 3.1 4.7e-31 107.2 3.1 1.5 1 0 0 1 1 1 1 MOFRL family DUF150_C PF17384.2 AIF84039.1 - 0.11 12.7 0.2 7.2 6.8 0.0 3.2 3 0 0 3 3 3 0 RimP C-terminal SH3 domain AIRC PF00731.20 AIF84039.1 - 0.28 10.8 4.8 3.9 7.0 0.5 3.5 3 1 1 4 4 4 0 AIR carboxylase BPL_LplA_LipB PF03099.19 AIF84040.1 - 3.9e-17 62.4 0.0 6.4e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family HTH_11 PF08279.12 AIF84040.1 - 1.1e-14 54.0 0.2 2.7e-14 52.8 0.2 1.7 1 0 0 1 1 1 1 HTH domain BPL_LplA_LipB_2 PF16917.5 AIF84040.1 - 1.6e-07 31.0 0.1 3.6e-07 29.9 0.2 1.6 1 1 1 2 2 2 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 AIF84040.1 - 1.5e-05 24.8 1.7 2.1e-05 24.3 0.1 2.2 3 0 0 3 3 3 1 Biotin protein ligase C terminal domain HTH_24 PF13412.6 AIF84040.1 - 0.0044 16.5 0.0 0.0089 15.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 AIF84040.1 - 0.0098 16.2 0.1 0.024 15.0 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulator HTH_36 PF13730.6 AIF84040.1 - 0.025 14.6 0.1 0.066 13.2 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_1 PF00126.27 AIF84040.1 - 0.04 13.9 0.1 0.1 12.6 0.0 1.7 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family Fe_dep_repress PF01325.19 AIF84040.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_AsnC-type PF13404.6 AIF84040.1 - 0.16 11.8 0.2 0.41 10.5 0.2 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain THF_DHG_CYH PF00763.23 AIF84041.1 - 0.021 15.1 0.1 0.026 14.8 0.1 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain DUF2087 PF09860.9 AIF84041.1 - 0.034 14.3 0.2 0.11 12.6 0.1 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) Pkinase_fungal PF17667.1 AIF84041.1 - 0.046 12.5 0.0 0.19 10.5 0.0 1.7 1 1 1 2 2 2 0 Fungal protein kinase Synaptobrevin PF00957.21 AIF84041.1 - 0.091 12.6 0.3 0.14 12.0 0.2 1.3 1 1 0 1 1 1 0 Synaptobrevin MMR_HSR1_C PF08438.10 AIF84042.1 - 2.1e-33 115.2 0.0 4.6e-33 114.1 0.0 1.6 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 AIF84042.1 - 2.4e-20 72.7 0.0 1.5e-19 70.1 0.0 2.3 3 0 0 3 3 3 1 50S ribosome-binding GTPase TGS PF02824.21 AIF84042.1 - 7.5e-10 38.7 0.0 1.4e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 AIF84042.1 - 1.2e-07 31.3 0.1 5.3e-06 26.1 0.4 2.8 3 0 0 3 3 3 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AIF84042.1 - 0.00044 20.3 0.0 0.08 13.0 0.0 2.3 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 AIF84042.1 - 0.021 14.4 0.1 3.3 7.2 0.0 2.7 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Imm51 PF15595.6 AIF84045.1 - 0.061 13.3 0.0 0.19 11.7 0.0 1.8 1 1 1 2 2 2 0 Immunity protein 51 DUF2171 PF09939.9 AIF84046.1 - 0.00089 19.5 0.0 0.0012 19.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2171) CoA_binding_2 PF13380.6 AIF84047.1 - 8.4e-40 135.9 0.3 9.6e-40 135.7 0.3 1.0 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.19 AIF84047.1 - 2.1e-06 28.3 0.3 3.9e-06 27.5 0.1 1.5 2 0 0 2 2 2 1 CoA binding domain DUF4849 PF16141.5 AIF84047.1 - 0.43 9.8 1.9 1.3 8.2 1.0 1.9 1 1 1 2 2 2 0 Putative glycoside hydrolase Family 18, chitinase_18 Fmp27 PF10344.9 AIF84048.1 - 0.0062 14.7 0.7 0.0084 14.3 0.7 1.1 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 cobW PF02492.19 AIF84048.1 - 0.041 13.5 0.0 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF5300 PF17224.3 AIF84050.1 - 0.0058 16.9 0.0 0.008 16.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5300) GATase_6 PF13522.6 AIF84051.1 - 1.9e-13 50.8 0.0 3.1e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AIF84051.1 - 2.6e-12 46.8 0.0 4.9e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 AIF84051.1 - 7.8e-06 25.0 0.0 1.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Pribosyltran PF00156.27 AIF84051.1 - 2e-05 24.2 0.0 3.7e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_2 PF00310.21 AIF84051.1 - 0.0013 17.5 0.0 0.042 12.6 0.0 2.5 3 0 0 3 3 3 1 Glutamine amidotransferases class-II AIRS_C PF02769.22 AIF84052.1 - 1.4e-47 161.7 0.6 1.6e-24 86.8 0.1 2.2 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.24 AIF84052.1 - 1.9e-39 134.2 0.9 6.2e-20 71.7 0.2 2.7 2 0 0 2 2 2 2 AIR synthase related protein, N-terminal domain FGAR-AT_linker PF18072.1 AIF84052.1 - 6.8e-08 32.9 0.1 2.2e-07 31.3 0.1 1.9 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain GATase_5 PF13507.6 AIF84053.1 - 4.8e-44 150.4 0.0 6.7e-44 149.9 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 AIF84053.1 - 1.1e-08 35.0 0.1 2.7e-08 33.8 0.0 1.7 2 0 0 2 2 2 1 DJ-1/PfpI family GATase_3 PF07685.14 AIF84053.1 - 3.2e-08 33.4 0.0 6e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 AIF84053.1 - 6.1e-07 29.4 0.0 1.4e-06 28.3 0.0 1.5 1 1 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 AIF84053.1 - 0.00082 19.3 0.0 0.0021 18.0 0.0 1.6 1 1 0 1 1 1 1 SNO glutamine amidotransferase family Peptidase_C26 PF07722.13 AIF84053.1 - 0.0036 17.1 0.0 0.0063 16.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 HSP33 PF01430.19 AIF84053.1 - 0.078 12.4 0.0 0.097 12.1 0.0 1.1 1 0 0 1 1 1 0 Hsp33 protein SSrecog PF03531.14 AIF84053.1 - 0.17 11.8 0.0 0.39 10.7 0.0 1.6 1 1 0 1 1 1 0 Structure-specific recognition protein (SSRP1) CBS PF00571.28 AIF84054.1 - 6.3e-30 103.4 6.8 1e-15 57.9 0.3 2.8 3 0 0 3 3 3 2 CBS domain IF3_N PF05198.16 AIF84054.1 - 0.1 12.9 0.3 0.41 10.9 0.1 2.1 2 1 0 2 2 2 0 Translation initiation factor IF-3, N-terminal domain PurS PF02700.14 AIF84055.1 - 4.1e-21 74.9 0.4 4.7e-21 74.8 0.4 1.0 1 0 0 1 1 1 1 Phosphoribosylformylglycinamidine (FGAM) synthase Nitroreductase PF00881.24 AIF84056.1 - 3.9e-18 66.1 0.0 1.2e-08 35.1 0.0 2.0 1 1 1 2 2 2 2 Nitroreductase family TM1586_NiRdase PF14512.6 AIF84056.1 - 9.3e-10 38.4 0.0 6.7e-08 32.4 0.0 2.5 1 1 0 1 1 1 1 Putative TM nitroreductase ABC2_membrane PF01061.24 AIF84057.1 - 5.9e-16 58.5 23.4 8.6e-16 58.0 23.4 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 AIF84057.1 - 3.6e-10 39.5 23.8 6.4e-10 38.7 23.6 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 AIF84058.1 - 9.6e-28 97.4 0.0 1.4e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIF84058.1 - 1.6e-10 41.3 0.0 1.4e-07 31.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIF84058.1 - 0.0055 16.2 0.0 0.46 9.9 0.0 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain TsaE PF02367.17 AIF84058.1 - 0.0059 16.6 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 AIF84058.1 - 0.0098 15.6 0.1 0.031 14.0 0.1 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 AIF84058.1 - 0.019 14.7 0.2 0.13 12.0 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 AIF84058.1 - 0.043 13.5 0.0 3.7 7.2 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain SbcCD_C PF13558.6 AIF84058.1 - 0.047 13.9 0.0 0.72 10.1 0.0 2.5 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA PF00004.29 AIF84058.1 - 0.071 13.5 0.0 0.14 12.6 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 AIF84058.1 - 0.089 13.3 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AIF84058.1 - 0.18 12.1 0.1 0.48 10.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain Peptidase_M50 PF02163.22 AIF84060.1 - 1.6e-24 86.6 1.4 5.6e-24 84.8 1.4 1.9 1 1 0 1 1 1 1 Peptidase family M50 PDZ_6 PF17820.1 AIF84060.1 - 1.5e-05 24.7 0.7 2.4e-05 24.1 0.7 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 AIF84060.1 - 0.041 14.2 0.0 0.085 13.2 0.0 1.5 1 0 0 1 1 1 0 PDZ domain Tricorn_PDZ PF14685.6 AIF84060.1 - 0.14 12.1 0.1 0.27 11.2 0.1 1.4 1 0 0 1 1 1 0 Tricorn protease PDZ domain DUF3099 PF11298.8 AIF84060.1 - 0.24 11.6 5.5 3.9 7.7 0.7 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) FA_desaturase PF00487.24 AIF84060.1 - 0.28 11.0 6.2 0.49 10.2 0.2 2.7 3 0 0 3 3 3 0 Fatty acid desaturase SnoaL_2 PF12680.7 AIF84061.1 - 6.9e-09 36.3 0.0 8.2e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain LEH PF07858.12 AIF84061.1 - 2.4e-05 24.4 0.0 4.1e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Limonene-1,2-epoxide hydrolase catalytic domain DUF4878 PF12870.7 AIF84061.1 - 0.035 14.4 0.1 0.055 13.8 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4878) HTH_24 PF13412.6 AIF84062.1 - 6.8e-18 64.0 1.9 2.2e-08 33.5 0.0 2.7 3 0 0 3 3 3 2 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF84062.1 - 1.4e-17 63.2 1.7 1.1e-09 37.9 0.4 3.1 3 0 0 3 3 3 2 AsnC-type helix-turn-helix domain HTH_5 PF01022.20 AIF84062.1 - 4.4e-05 23.3 0.1 0.00018 21.3 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 AIF84062.1 - 7.6e-05 22.5 0.2 0.23 11.4 0.0 2.8 2 0 0 2 2 2 2 MarR family HTH_9 PF08221.11 AIF84062.1 - 7.6e-05 22.7 0.4 0.012 15.7 0.0 2.6 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HMA PF00403.26 AIF84062.1 - 0.00046 20.6 0.6 0.00096 19.6 0.6 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain HTH_IclR PF09339.10 AIF84062.1 - 0.00087 19.0 0.5 0.15 11.9 0.0 2.8 3 0 0 3 3 3 1 IclR helix-turn-helix domain HTH_20 PF12840.7 AIF84062.1 - 0.0013 18.8 0.5 0.13 12.3 0.0 3.3 3 0 0 3 3 3 1 Helix-turn-helix domain LexA_DNA_bind PF01726.16 AIF84062.1 - 0.015 15.1 0.1 0.46 10.3 0.0 2.4 2 0 0 2 2 2 0 LexA DNA binding domain HTH_Mga PF08280.11 AIF84062.1 - 0.02 14.9 0.0 0.049 13.7 0.0 1.7 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain SnoaL_2 PF12680.7 AIF84063.1 - 1.4e-11 44.9 0.0 1.7e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 AIF84063.1 - 7.1e-07 29.1 0.0 6.4e-05 22.8 0.0 2.0 1 1 0 1 1 1 1 SnoaL-like polyketide cyclase DUF4440 PF14534.6 AIF84063.1 - 0.0046 17.3 0.0 0.0056 17.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) LEH PF07858.12 AIF84063.1 - 0.02 15.0 0.1 0.062 13.4 0.1 1.7 1 1 0 1 1 1 0 Limonene-1,2-epoxide hydrolase catalytic domain DUF4878 PF12870.7 AIF84063.1 - 0.032 14.5 0.1 0.065 13.5 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4878) HTH_AsnC-type PF13404.6 AIF84064.1 - 4.3e-18 64.9 0.4 3.8e-11 42.6 0.7 2.8 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 AIF84064.1 - 9.6e-18 63.5 0.2 5.2e-08 32.3 0.1 2.5 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 AIF84064.1 - 9.2e-06 25.4 0.0 0.00024 20.9 0.0 2.4 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 AIF84064.1 - 1.2e-05 25.1 0.2 0.087 12.7 0.0 2.7 2 1 0 2 2 2 2 MarR family HTH_20 PF12840.7 AIF84064.1 - 0.00027 20.9 0.1 0.0057 16.7 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain HMA PF00403.26 AIF84064.1 - 0.005 17.3 0.7 0.011 16.1 0.7 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain HTH_Mga PF08280.11 AIF84064.1 - 0.0089 16.0 0.1 0.027 14.5 0.1 1.8 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain Mga PF05043.13 AIF84064.1 - 0.028 15.0 0.0 1.2 9.7 0.0 2.3 2 0 0 2 2 2 0 Mga helix-turn-helix domain HTH_9 PF08221.11 AIF84064.1 - 0.071 13.2 0.4 0.36 11.0 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_IclR PF09339.10 AIF84064.1 - 0.12 12.2 0.2 0.49 10.2 0.0 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain SnoaL PF07366.12 AIF84065.1 - 1.8e-25 89.2 0.6 2.4e-25 88.8 0.6 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 AIF84065.1 - 8.9e-18 64.8 0.3 1.4e-17 64.2 0.3 1.3 1 1 0 1 1 1 1 SnoaL-like domain LEH PF07858.12 AIF84065.1 - 0.00024 21.2 0.3 0.00028 21.0 0.3 1.0 1 0 0 1 1 1 1 Limonene-1,2-epoxide hydrolase catalytic domain Methyltransf_25 PF13649.6 AIF84066.1 - 2.4e-21 76.2 0.0 4.2e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF84066.1 - 7.3e-19 68.2 0.0 1.2e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF84066.1 - 9.3e-16 58.1 0.0 1.1e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF84066.1 - 8.1e-14 51.7 0.0 1e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF84066.1 - 6.2e-10 39.7 0.0 1.2e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF84066.1 - 7.9e-08 31.9 0.0 1.1e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 AIF84066.1 - 3.8e-06 26.4 0.0 5e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 AIF84066.1 - 1.3e-05 25.1 0.0 2.5e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_29 PF03141.16 AIF84066.1 - 5.6e-05 21.9 0.0 7e-05 21.6 0.0 1.0 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase TehB PF03848.14 AIF84066.1 - 0.00012 21.6 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB CheR PF01739.18 AIF84066.1 - 0.00055 19.5 0.0 0.16 11.4 0.0 2.2 1 1 1 2 2 2 2 CheR methyltransferase, SAM binding domain Methyltransf_8 PF05148.15 AIF84066.1 - 0.00065 19.6 0.0 0.0015 18.4 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase FtsJ PF01728.19 AIF84066.1 - 0.0035 17.5 0.0 0.013 15.6 0.0 1.9 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 AIF84066.1 - 0.0045 17.0 0.0 0.0064 16.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 AIF84066.1 - 0.011 15.4 0.0 0.032 13.9 0.0 1.8 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) N6_N4_Mtase PF01555.18 AIF84066.1 - 0.023 14.4 0.0 3.5 7.3 0.0 2.1 2 0 0 2 2 2 0 DNA methylase MTS PF05175.14 AIF84066.1 - 0.051 13.1 0.0 0.083 12.4 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain PRONE PF03759.13 AIF84066.1 - 0.079 11.8 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 PRONE (Plant-specific Rop nucleotide exchanger) MetW PF07021.12 AIF84066.1 - 0.14 11.7 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW CPP1-like PF11833.8 AIF84067.1 - 0.011 15.5 1.5 0.015 14.9 1.5 1.3 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF3096 PF11295.8 AIF84067.1 - 0.024 14.3 1.0 0.024 14.3 1.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3096) Yip1 PF04893.17 AIF84067.1 - 0.067 12.9 8.7 0.082 12.6 8.7 1.1 1 0 0 1 1 1 0 Yip1 domain DUF4153 PF13687.6 AIF84067.1 - 0.38 10.4 6.7 0.12 11.9 3.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4153) DUF4383 PF14325.6 AIF84067.1 - 0.67 10.2 8.9 2.9 8.2 9.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4383) KH_7 PF17214.3 AIF84069.1 - 1.1e-21 76.5 0.1 6.3e-20 70.9 0.1 2.9 2 0 0 2 2 2 1 KH domain Beta-Casp PF10996.8 AIF84069.1 - 1.9e-21 76.4 0.0 4.1e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 AIF84069.1 - 3.7e-16 59.1 0.0 6.5e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 AIF84069.1 - 3.2e-15 55.8 0.0 7.1e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 AIF84069.1 - 1.2e-10 41.7 0.0 8.9e-10 38.9 0.0 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AIF84069.1 - 2.3e-09 37.1 0.0 8.2e-08 32.0 0.0 2.5 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AIF84069.1 - 0.066 13.1 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Beta-lactamase superfamily domain HisKA_3 PF07730.13 AIF84071.1 - 0.0087 16.6 9.4 0.06 13.9 0.1 3.8 1 1 3 4 4 4 1 Histidine kinase Focal_AT PF03623.13 AIF84071.1 - 0.011 15.7 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Focal adhesion targeting region DUF746 PF05344.11 AIF84071.1 - 0.038 13.8 0.0 0.079 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) HrpB4 PF09502.10 AIF84071.1 - 0.04 13.7 3.0 0.05 13.4 3.0 1.1 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB4) DUF948 PF06103.11 AIF84071.1 - 0.14 12.4 7.6 9.3 6.6 6.6 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4404 PF14357.6 AIF84071.1 - 0.2 12.3 0.7 0.62 10.7 0.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) ApoLp-III PF07464.11 AIF84071.1 - 0.26 11.4 8.9 1.7 8.7 8.9 2.2 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) REF PF05755.12 AIF84071.1 - 3.1 7.6 8.1 36 4.1 7.7 2.5 1 1 1 2 2 2 0 Rubber elongation factor protein (REF) SesA PF17107.5 AIF84071.1 - 9.3 6.5 8.6 14 5.9 0.4 2.2 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases UPF0147 PF03685.13 AIF84072.1 - 5.2e-27 93.7 3.0 6.1e-27 93.5 3.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0147) Ribosomal_S20p PF01649.18 AIF84072.1 - 0.009 16.6 4.1 0.055 14.1 3.9 2.2 1 1 0 1 1 1 1 Ribosomal protein S20 Prp18 PF02840.15 AIF84072.1 - 0.31 11.1 3.7 0.57 10.2 1.9 1.9 1 1 1 2 2 2 0 Prp18 domain PadR PF03551.14 AIF84073.1 - 0.021 14.8 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_45 PF14947.6 AIF84073.1 - 0.065 13.2 0.0 0.12 12.4 0.0 1.6 1 1 0 1 1 1 0 Winged helix-turn-helix DUF505 PF04458.12 AIF84073.1 - 0.12 10.8 0.0 0.13 10.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF505) HTH_27 PF13463.6 AIF84073.1 - 0.16 12.5 0.0 0.89 10.1 0.0 2.0 2 0 0 2 2 2 0 Winged helix DNA-binding domain zf-C2H2_2 PF12756.7 AIF84074.1 - 0.0025 18.1 0.1 0.0028 18.0 0.1 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) DUF4715 PF15835.5 AIF84074.1 - 0.03 14.4 0.1 0.035 14.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4715) Usp PF00582.26 AIF84075.1 - 6.9e-36 123.9 0.2 7.7e-36 123.7 0.2 1.0 1 0 0 1 1 1 1 Universal stress protein family PGM_PMM_I PF02878.16 AIF84075.1 - 0.099 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Na_Ca_ex PF01699.24 AIF84077.1 - 1.3e-27 96.6 36.8 2.9e-14 53.3 14.6 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF1516 PF07457.11 AIF84077.1 - 0.057 13.6 11.2 0.15 12.3 1.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1516) Spore_YabQ PF09578.10 AIF84077.1 - 0.34 11.2 10.5 0.53 10.5 7.0 2.7 2 0 0 2 2 2 0 Spore cortex protein YabQ (Spore_YabQ) Methyltransf_31 PF13847.6 AIF84078.1 - 0.018 14.8 0.3 0.031 14.1 0.3 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 AIF84078.1 - 0.055 14.2 0.1 0.098 13.4 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 AIF84078.1 - 0.073 12.7 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_23 PF13489.6 AIF84078.1 - 0.098 12.5 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Zn_Tnp_IS1595 PF12760.7 AIF84079.1 - 0.0019 18.1 1.2 0.0024 17.8 1.2 1.2 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Rubredoxin_2 PF18073.1 AIF84079.1 - 0.036 13.8 1.0 0.047 13.4 1.0 1.2 1 0 0 1 1 1 0 Rubredoxin metal binding domain DUF1451 PF07295.11 AIF84079.1 - 0.073 13.1 0.2 0.086 12.9 0.2 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain DNA_RNApol_7kD PF03604.13 AIF84079.1 - 0.13 12.0 5.1 0.29 10.9 5.1 1.7 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit ATP-synt_B PF00430.18 AIF84080.1 - 0.018 15.1 12.4 0.02 14.9 12.4 1.1 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) DUF883 PF05957.13 AIF84080.1 - 0.062 13.9 4.0 0.092 13.4 4.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Borrelia_P83 PF05262.11 AIF84080.1 - 0.19 10.2 12.2 0.2 10.1 12.2 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein MT0933_antitox PF14013.6 AIF84080.1 - 0.54 10.6 18.1 2 8.8 8.5 2.6 2 1 0 2 2 2 0 MT0933-like antitoxin protein YtxH PF12732.7 AIF84080.1 - 0.66 10.6 11.4 2.7 8.6 11.4 1.8 1 1 0 1 1 1 0 YtxH-like protein V-ATPase_G_2 PF16999.5 AIF84080.1 - 0.82 10.1 13.0 1.6 9.2 13.0 1.4 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit CENP-H PF05837.12 AIF84080.1 - 2.1 8.8 7.7 2.4 8.6 7.7 1.0 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Malectin_like PF12819.7 AIF84081.1 - 0.039 13.1 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 Malectin-like domain CrtC PF07143.11 AIF84082.1 - 4e-07 30.9 3.2 1.1e-06 29.4 0.8 2.3 2 1 0 2 2 2 1 CrtC N-terminal lipocalin domain Svf1 PF08622.10 AIF84082.1 - 0.028 14.5 0.0 0.076 13.1 0.0 1.7 1 1 0 1 1 1 0 Svf1-like N-terminal lipocalin domain DUF3021 PF11457.8 AIF84084.1 - 0.0088 16.4 1.1 0.01 16.2 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3021) SurA_N_2 PF13623.6 AIF84084.1 - 0.015 15.1 0.5 0.02 14.8 0.4 1.3 1 1 0 1 1 1 0 SurA N-terminal domain Fuseless PF15993.5 AIF84084.1 - 0.07 12.3 4.9 0.11 11.7 4.9 1.3 1 1 0 1 1 1 0 Fuseless FeoB_associated PF12669.7 AIF84084.1 - 0.096 13.1 2.4 0.29 11.6 0.1 2.2 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Glyoxalase PF00903.25 AIF84085.1 - 2.7e-08 34.1 0.0 5e-08 33.2 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 AIF84085.1 - 0.00017 21.5 0.0 0.00033 20.6 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 AIF84085.1 - 0.011 16.0 0.0 0.021 15.1 0.0 1.5 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AIF84085.1 - 0.023 15.5 0.0 0.028 15.2 0.0 1.1 1 0 0 1 1 1 0 Glyoxalase-like domain Glyoxalase_3 PF13468.6 AIF84085.1 - 0.064 13.4 0.0 0.12 12.4 0.0 1.5 1 1 0 1 1 1 0 Glyoxalase-like domain DUF4256 PF14066.6 AIF84086.1 - 3e-39 134.5 0.1 3.3e-39 134.4 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4256) CoA_binding PF02629.19 AIF84090.1 - 3.9e-22 78.7 0.5 1.2e-21 77.2 0.5 1.8 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 AIF84090.1 - 3.1e-09 36.8 0.0 5.7e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding_2 PF13380.6 AIF84090.1 - 2.2e-05 24.9 0.0 5e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.6 AIF84090.1 - 0.00022 21.0 0.0 0.00035 20.4 0.0 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain ATP-grasp_2 PF08442.10 AIF84091.1 - 9.2e-40 136.4 0.0 1.6e-39 135.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 AIF84091.1 - 1.2e-13 51.2 1.2 2.1e-13 50.4 1.2 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 AIF84091.1 - 1.5e-13 50.8 0.1 1.5e-12 47.4 0.1 2.2 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 AIF84091.1 - 7.9e-05 22.3 0.0 0.00014 21.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 AIF84091.1 - 0.00031 20.3 0.0 0.00064 19.3 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PHINT_rpt PF14882.6 AIF84091.1 - 0.15 12.4 0.3 0.51 10.6 0.2 2.0 2 0 0 2 2 2 0 Phage-integrase repeat unit Transp_cyt_pur PF02133.15 AIF84092.1 - 4.4e-29 101.5 37.4 6.6e-29 101.0 37.4 1.3 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin ThiC_Rad_SAM PF01964.18 AIF84093.1 - 4.6e-173 575.8 0.2 5.3e-173 575.6 0.2 1.0 1 0 0 1 1 1 1 Radical SAM ThiC family Halo_GVPC PF05465.13 AIF84094.1 - 0.058 13.7 1.1 0.11 12.8 0.8 1.6 1 1 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat DUF883 PF05957.13 AIF84096.1 - 0.057 14.0 0.5 0.07 13.7 0.5 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Phos_pyr_kin PF08543.12 AIF84097.1 - 6.2e-86 287.8 3.1 8.8e-86 287.3 3.1 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase ThiP_synth PF10120.9 AIF84097.1 - 2.6e-55 186.5 2.6 7.2e-54 181.8 0.7 2.6 3 0 0 3 3 3 1 Thiamine-phosphate synthase PfkB PF00294.24 AIF84097.1 - 2.4e-15 56.7 0.1 4.5e-15 55.7 0.1 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 AIF84097.1 - 7.4e-05 22.3 1.4 0.00013 21.4 1.4 1.4 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family RE_HindVP PF09519.10 AIF84097.1 - 0.029 13.4 0.0 0.047 12.7 0.0 1.2 1 0 0 1 1 1 0 HindVP restriction endonuclease NTP_transferase PF00483.23 AIF84098.1 - 7.4e-36 124.0 0.0 8.3e-36 123.8 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 AIF84098.1 - 4.6e-12 46.6 0.0 6.2e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.19 AIF84098.1 - 1.8e-05 24.8 0.0 2.8e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase IspD PF01128.19 AIF84098.1 - 0.0014 18.4 0.0 0.0022 17.8 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NTP_transf_4 PF13562.6 AIF84099.1 - 5.9e-14 52.6 0.1 8.9e-14 52.0 0.1 1.3 1 0 0 1 1 1 1 Sugar nucleotidyl transferase Hexapep PF00132.24 AIF84099.1 - 7.9e-05 22.2 0.2 1.4 8.7 0.0 4.4 3 1 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 AIF84099.1 - 0.062 11.4 1.1 0.46 8.6 0.9 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) SHOCT PF09851.9 AIF84100.1 - 1.9e-07 30.6 0.3 2.8e-07 30.0 0.3 1.3 1 0 0 1 1 1 1 Short C-terminal domain DUF4381 PF14316.6 AIF84100.1 - 0.036 14.3 0.3 0.062 13.5 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) FtsX PF02687.21 AIF84100.1 - 0.051 14.1 1.3 0.068 13.6 1.3 1.2 1 0 0 1 1 1 0 FtsX-like permease family GH-E PF14410.6 AIF84100.1 - 0.057 13.8 0.0 0.094 13.1 0.0 1.3 1 0 0 1 1 1 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues DUF1707 PF08044.11 AIF84100.1 - 0.064 13.3 0.1 0.095 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1707) MLANA PF14991.6 AIF84100.1 - 0.14 12.4 0.1 0.45 10.8 0.0 1.7 2 0 0 2 2 2 0 Protein melan-A FixQ PF05545.11 AIF84100.1 - 0.97 9.4 0.0 0.97 9.4 0.0 2.9 2 1 1 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ DUF2207 PF09972.9 AIF84100.1 - 3.3 6.4 5.9 4.7 5.9 5.9 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Epimerase_2 PF02350.19 AIF84103.1 - 9.7e-29 100.3 0.0 2.9e-25 88.8 0.0 2.1 2 0 0 2 2 2 2 UDP-N-acetylglucosamine 2-epimerase 7TMR-DISM_7TM PF07695.11 AIF84104.1 - 0.06 13.2 5.5 0.13 12.1 5.5 1.6 1 1 0 1 1 1 0 7TM diverse intracellular signalling GalP_UDP_transf PF01087.22 AIF84105.1 - 2.2e-12 47.8 0.0 5.4e-10 40.0 0.0 2.3 2 0 0 2 2 2 2 Galactose-1-phosphate uridyl transferase, N-terminal domain DUF4921 PF16268.5 AIF84105.1 - 2.2e-08 33.4 0.0 7.1e-08 31.7 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4921) HIT PF01230.23 AIF84105.1 - 1.8e-07 31.8 0.0 0.0013 19.4 0.0 2.6 3 0 0 3 3 3 2 HIT domain GalP_UDP_tr_C PF02744.17 AIF84105.1 - 2.3e-05 24.2 0.0 4.1e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DcpS_C PF11969.8 AIF84105.1 - 0.0099 16.4 0.0 0.019 15.5 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF4931 PF16285.5 AIF84105.1 - 0.022 14.1 0.4 0.055 12.8 0.1 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4931) Metal_resist PF13801.6 AIF84106.1 - 0.0028 17.8 0.0 0.0033 17.6 0.0 1.1 1 0 0 1 1 1 1 Heavy-metal resistance PhosphMutase PF10143.9 AIF84107.1 - 1.9e-44 151.6 0.1 2.6e-44 151.1 0.1 1.2 1 0 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.18 AIF84107.1 - 6.8e-24 84.6 0.1 8.5e-24 84.3 0.1 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 AIF84107.1 - 0.02 14.5 0.0 0.13 11.8 0.0 2.0 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase Gram_pos_anchor PF00746.21 AIF84108.1 - 0.00024 20.9 0.4 0.00024 20.9 0.4 2.0 1 1 1 2 2 2 1 LPXTG cell wall anchor motif DUF4131 PF13567.6 AIF84108.1 - 0.0066 16.1 0.0 0.0073 16.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) DUF4379 PF14311.6 AIF84109.1 - 0.0055 17.0 0.6 0.008 16.5 0.6 1.4 1 0 0 1 1 1 1 Probable Zinc-ribbon domain DZR PF12773.7 AIF84109.1 - 0.0056 16.7 1.2 0.0081 16.2 1.2 1.3 1 0 0 1 1 1 1 Double zinc ribbon NOB1_Zn_bind PF08772.11 AIF84109.1 - 0.04 14.1 0.1 0.044 14.0 0.1 1.1 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like DUF2321 PF10083.9 AIF84109.1 - 0.069 12.8 0.3 0.075 12.7 0.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) A2L_zn_ribbon PF08792.10 AIF84109.1 - 0.071 12.8 3.3 3.3 7.6 0.2 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zinc_ribbon_2 PF13240.6 AIF84109.1 - 0.11 12.3 4.5 2.8 7.8 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain RNA_POL_M_15KD PF02150.16 AIF84109.1 - 4.2 7.3 8.3 73 3.4 8.3 2.1 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit TFIIB PF00382.19 AIF84110.1 - 1.2e-25 89.3 3.8 8.1e-13 48.2 1.6 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIF84110.1 - 7.8e-09 34.9 0.6 7.8e-09 34.9 0.6 1.9 2 0 0 2 2 2 1 TFIIB zinc-binding Cyclin_N PF00134.23 AIF84110.1 - 0.007 16.1 4.2 0.043 13.6 3.5 2.3 1 1 1 2 2 2 1 Cyclin, N-terminal domain SGT1 PF07093.11 AIF84110.1 - 0.028 12.9 0.1 0.039 12.4 0.1 1.2 1 0 0 1 1 1 0 SGT1 protein OrfB_Zn_ribbon PF07282.11 AIF84110.1 - 0.048 13.6 1.9 0.048 13.6 1.9 1.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain zf-C4_Topoisom PF01396.19 AIF84110.1 - 0.069 13.0 1.9 0.59 10.0 0.8 2.5 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Auto_anti-p27 PF06677.12 AIF84110.1 - 4.1 7.6 6.1 1.4 9.1 2.3 2.2 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Gar1 PF04410.14 AIF84111.1 - 3.2e-07 30.3 0.0 3.7e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region GTP_EFTU_D4 PF14578.6 AIF84111.1 - 0.039 13.9 0.6 0.69 9.9 0.1 2.1 1 1 1 2 2 2 0 Elongation factor Tu domain 4 SRP19 PF01922.17 AIF84112.1 - 9.9e-15 55.3 0.2 1.3e-14 54.9 0.2 1.1 1 0 0 1 1 1 1 SRP19 protein GTP-bdg_N PF13167.6 AIF84112.1 - 0.098 13.3 0.1 0.2 12.3 0.1 1.6 2 0 0 2 2 2 0 GTP-binding GTPase N-terminal Big_9 PF17963.1 AIF84113.1 - 6.6e-21 74.9 11.7 6.6e-21 74.9 11.7 5.6 3 3 1 4 4 4 1 Bacterial Ig domain VWA PF00092.28 AIF84113.1 - 1e-18 68.2 0.1 2.2e-18 67.1 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Cadherin_5 PF17892.1 AIF84113.1 - 4.3e-18 65.1 4.2 4.3e-18 65.1 4.2 3.7 3 1 1 4 4 4 1 Cadherin-like domain Cadherin_4 PF17803.1 AIF84113.1 - 2.5e-17 63.3 7.5 2.5e-17 63.3 7.5 5.6 3 3 2 5 5 5 1 Bacterial cadherin-like domain VWA_2 PF13519.6 AIF84113.1 - 1.3e-15 57.9 0.2 3.6e-15 56.5 0.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 AIF84113.1 - 3.7e-05 23.7 0.0 0.00013 21.9 0.0 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain Ribosomal_S8e PF01201.22 AIF84114.1 - 2.6e-27 95.7 3.9 2.9e-27 95.5 3.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e SMC_ScpB PF04079.16 AIF84118.1 - 3.7e-36 124.2 0.9 4.6e-36 123.9 0.9 1.1 1 0 0 1 1 1 1 Segregation and condensation complex subunit ScpB HTH_20 PF12840.7 AIF84118.1 - 0.00058 19.9 0.1 0.05 13.7 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain TrmB PF01978.19 AIF84118.1 - 0.01 15.7 2.9 0.1 12.5 0.1 2.7 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB PadR PF03551.14 AIF84118.1 - 0.042 13.8 0.2 0.34 10.9 0.1 2.3 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family DprA_WH PF17782.1 AIF84118.1 - 0.085 13.0 0.1 0.23 11.6 0.1 1.7 1 0 0 1 1 1 0 DprA winged helix domain HTH_15 PF12324.8 AIF84118.1 - 0.087 12.8 0.1 10 6.1 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase SMC_ScpA PF02616.14 AIF84119.1 - 2e-09 37.8 0.3 0.001 19.1 0.0 2.1 2 0 0 2 2 2 2 Segregation and condensation protein ScpA CNDH2_C PF16858.5 AIF84119.1 - 2.5e-05 24.3 0.0 3.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term Tma16 PF11176.8 AIF84120.1 - 0.067 13.1 0.1 0.11 12.4 0.1 1.3 1 1 0 1 1 1 0 Translation machinery-associated protein 16 HypD PF01924.16 AIF84120.1 - 0.11 11.5 0.1 0.16 11.0 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase formation hypA family TarH PF02203.15 AIF84120.1 - 0.35 10.8 5.7 2.9 7.8 1.6 2.2 2 0 0 2 2 2 0 Tar ligand binding domain homologue Patatin PF01734.22 AIF84121.1 - 1.8e-11 44.6 0.0 4.5e-11 43.3 0.0 1.7 2 0 0 2 2 2 1 Patatin-like phospholipase ABC_tran_CTD PF16326.5 AIF84121.1 - 0.085 13.1 0.5 0.32 11.3 0.4 2.0 2 0 0 2 2 2 0 ABC transporter C-terminal domain FliD_C PF07195.12 AIF84121.1 - 0.097 12.1 0.1 0.2 11.1 0.1 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Patatin PF01734.22 AIF84122.1 - 3.6e-12 46.9 0.0 4.4e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase zf-C2H2 PF00096.26 AIF84123.1 - 0.00031 21.0 0.2 0.00031 21.0 0.2 1.6 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-met PF12874.7 AIF84123.1 - 0.00043 20.6 0.5 0.00043 20.6 0.5 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 AIF84123.1 - 0.012 15.9 0.5 0.014 15.7 0.5 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 AIF84123.1 - 0.015 16.1 0.2 0.015 16.1 0.2 1.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-DBF PF07535.12 AIF84123.1 - 0.04 14.0 0.7 0.06 13.5 0.7 1.3 1 0 0 1 1 1 0 DBF zinc finger zf-H2C2_2 PF13465.6 AIF84123.1 - 0.044 14.2 1.2 0.67 10.5 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AIF84123.1 - 0.068 13.5 0.2 0.068 13.5 0.2 1.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Copper-bind PF00127.20 AIF84124.1 - 1.1e-12 48.3 0.1 1.5e-12 47.8 0.1 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF84124.1 - 5.6e-07 29.6 0.0 1.4e-06 28.4 0.0 1.6 1 1 0 1 1 1 1 Cupredoxin-like domain C1-set PF07654.15 AIF84124.1 - 0.032 14.6 0.1 0.053 13.9 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin C1-set domain DUF2175 PF09943.9 AIF84124.1 - 0.17 12.2 0.1 0.32 11.3 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) HTH_45 PF14947.6 AIF84125.1 - 4.8e-18 64.9 0.2 8.1e-18 64.2 0.2 1.4 1 1 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIF84125.1 - 0.007 16.1 0.1 0.0093 15.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_27 PF13463.6 AIF84125.1 - 0.028 14.9 0.1 0.063 13.8 0.0 1.6 1 1 0 1 1 1 0 Winged helix DNA-binding domain HTH_45 PF14947.6 AIF84126.1 - 1.7e-17 63.1 0.0 6e-17 61.4 0.0 1.7 1 1 0 1 1 1 1 Winged helix-turn-helix DUF505 PF04458.12 AIF84126.1 - 0.049 12.0 0.0 0.05 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF505) MEDS PF14417.6 AIF84128.1 - 1.8e-14 53.9 0.0 2.3e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain ATPase PF06745.13 AIF84128.1 - 0.00057 19.3 0.0 0.00075 18.9 0.0 1.2 1 0 0 1 1 1 1 KaiC HTH_45 PF14947.6 AIF84129.1 - 4.2e-14 52.3 0.3 6.6e-14 51.7 0.3 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DUF1428 PF07237.11 AIF84130.1 - 1.2e-06 28.7 0.1 1.6e-06 28.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1428) Cytochrom_B562 PF07361.11 AIF84130.1 - 0.043 14.5 0.1 0.1 13.2 0.0 1.7 1 1 0 1 1 1 0 Cytochrome b562 Methyltransf_21 PF05050.12 AIF84132.1 - 3.4e-21 76.0 0.0 4.5e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Met_10 PF02475.16 AIF84132.1 - 1.5e-09 37.9 0.0 2.2e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein V_cholerae_RfbT PF05575.11 AIF84132.1 - 3.3e-06 26.6 0.0 5.5e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Vibrio cholerae RfbT protein Methyltransf_23 PF13489.6 AIF84132.1 - 0.0021 17.9 0.0 0.0034 17.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 AIF84132.1 - 0.0095 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 AIF84132.1 - 0.015 14.4 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase MTS PF05175.14 AIF84132.1 - 0.018 14.6 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_11 PF08241.12 AIF84132.1 - 0.039 14.6 0.0 0.077 13.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Glyco_hydro_114 PF03537.13 AIF84132.1 - 0.041 13.2 0.0 0.064 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycoside-hydrolase family GH114 Methyltransf_25 PF13649.6 AIF84132.1 - 0.055 14.2 0.0 0.31 11.8 0.0 2.0 1 1 1 2 2 2 0 Methyltransferase domain tRNA_U5-meth_tr PF05958.11 AIF84132.1 - 0.085 11.8 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase HTH_24 PF13412.6 AIF84134.1 - 0.0002 20.8 0.4 0.00049 19.6 0.4 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF84134.1 - 0.0029 17.4 0.8 0.0054 16.5 0.1 1.9 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain PSCyt3 PF07627.11 AIF84136.1 - 0.0064 16.7 0.6 0.01 16.1 0.1 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1588) FYVE PF01363.21 AIF84136.1 - 0.025 14.7 0.1 1.1 9.5 0.0 2.1 2 0 0 2 2 2 0 FYVE zinc finger zf-RING_4 PF14570.6 AIF84136.1 - 0.036 13.9 0.2 6.3 6.7 0.1 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.25 AIF84136.1 - 0.045 13.6 0.5 11 5.9 0.1 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 AIF84136.1 - 0.11 12.5 0.5 0.27 11.3 0.5 1.6 1 1 0 1 1 1 0 Double zinc ribbon CopG_antitoxin PF12441.8 AIF84137.1 - 0.00076 20.0 0.0 0.002 18.6 0.0 1.7 1 0 0 1 1 1 1 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIF84137.1 - 0.035 13.9 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 HicB family Arc PF03869.14 AIF84137.1 - 0.065 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Arc-like DNA binding domain SBP_bac_3 PF00497.20 AIF84138.1 - 7.1e-58 195.7 0.1 8.2e-58 195.5 0.1 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 AIF84138.1 - 6.6e-07 29.5 0.0 1.1e-06 28.8 0.0 1.5 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site Phosphonate-bd PF12974.7 AIF84138.1 - 0.075 12.6 1.6 4.5 6.8 0.6 2.2 1 1 1 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein BUD22 PF09073.10 AIF84140.1 - 0.41 9.9 19.0 0.52 9.6 19.0 1.3 1 0 0 1 1 1 0 BUD22 bPH_3 PF14470.6 AIF84144.1 - 0.005 17.2 0.0 0.0061 16.9 0.0 1.1 1 0 0 1 1 1 1 Bacterial PH domain bPH_1 PF08000.11 AIF84144.1 - 0.019 15.1 0.1 0.022 14.9 0.1 1.2 1 0 0 1 1 1 0 Bacterial PH domain Wzz PF02706.15 AIF84145.1 - 0.039 14.3 1.6 0.039 14.3 1.6 2.3 3 0 0 3 3 3 0 Chain length determinant protein MG2 PF01835.19 AIF84145.1 - 0.072 13.6 6.4 0.08 13.4 0.2 2.7 2 0 0 2 2 2 0 MG2 domain DUF2852 PF11014.8 AIF84145.1 - 0.58 10.3 0.0 0.58 10.3 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2852) RXLR PF16810.5 AIF84145.1 - 2.4 8.6 5.3 0.38 11.2 1.1 1.9 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity MarR_2 PF12802.7 AIF84146.1 - 0.00096 19.0 0.0 0.0037 17.1 0.0 2.0 1 0 0 1 1 1 1 MarR family Cupredoxin_1 PF13473.6 AIF84146.1 - 0.0015 18.6 0.0 0.0059 16.7 0.0 2.1 2 0 0 2 2 2 1 Cupredoxin-like domain HTH_IclR PF09339.10 AIF84146.1 - 0.007 16.1 0.0 0.021 14.6 0.0 1.7 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.6 AIF84146.1 - 0.0093 15.5 0.1 0.017 14.7 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding DUF5129 PF17173.4 AIF84146.1 - 0.066 12.3 0.1 0.066 12.3 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5129) MarR PF01047.22 AIF84146.1 - 0.15 12.0 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 MarR family ATP-synt_DE PF00401.20 AIF84146.1 - 0.25 11.6 0.2 0.25 11.6 0.2 2.5 3 0 0 3 3 3 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain SNAP PF14938.6 AIF84146.1 - 0.68 9.3 7.4 1 8.7 7.4 1.2 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP PhoR PF11808.8 AIF84149.1 - 0.38 11.2 0.1 0.38 11.2 0.1 5.0 4 2 3 7 7 7 0 Phosphate regulon sensor protein PhoR zf-C2H2_6 PF13912.6 AIF84150.1 - 0.00027 20.9 1.7 0.0096 15.9 0.7 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger DUF629 PF04780.12 AIF84150.1 - 0.019 13.5 0.5 0.019 13.5 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-C2H2_4 PF13894.6 AIF84150.1 - 0.034 15.0 1.9 0.053 14.4 1.0 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-RanBP PF00641.18 AIF84150.1 - 0.042 13.2 1.0 0.078 12.3 1.0 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others DUF3825 PF12873.7 AIF84152.1 - 0.0073 15.8 0.4 0.0095 15.4 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3825) Vps51 PF08700.11 AIF84152.1 - 0.033 14.3 0.2 0.48 10.5 0.0 2.5 2 0 0 2 2 2 0 Vps51/Vps67 Rft-1 PF04506.13 AIF84153.1 - 0.018 13.8 0.1 0.022 13.5 0.1 1.1 1 0 0 1 1 1 0 Rft protein Oxidored_q2 PF00420.24 AIF84153.1 - 0.04 13.6 0.2 0.04 13.6 0.2 1.9 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF4149 PF13664.6 AIF84153.1 - 0.23 11.8 1.8 14 6.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) Hol_Tox PF16935.5 AIF84153.1 - 1.1 9.4 4.6 2.3 8.3 0.2 2.5 2 0 0 2 2 2 0 Putative Holin-like Toxin (Hol-Tox) BaxI_1 PF12811.7 AIF84153.1 - 3.5 7.1 8.0 3.8 7.0 3.4 2.2 1 1 0 2 2 2 0 Bax inhibitor 1 like HemX PF04375.14 AIF84154.1 - 0.018 14.4 1.4 0.059 12.7 0.2 2.1 3 0 0 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase DcuC PF03606.15 AIF84154.1 - 0.087 11.3 0.1 0.12 10.8 0.1 1.4 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier MPS-4 PF17523.2 AIF84154.1 - 0.23 11.6 0.9 0.84 9.8 0.0 2.1 2 0 0 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 Borrelia_P13 PF05628.12 AIF84156.1 - 0.013 15.5 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 Borrelia membrane protein P13 MIT_C PF16565.5 AIF84157.1 - 0.0068 16.4 0.3 0.0079 16.2 0.3 1.3 1 0 0 1 1 1 1 Phospholipase D-like domain at C-terminus of MIT HTH_ParB PF17762.1 AIF84158.1 - 0.018 14.8 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 HTH domain found in ParB protein hDGE_amylase PF14701.6 AIF84159.1 - 0.063 12.4 0.0 0.078 12.1 0.0 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain DUF4145 PF13643.6 AIF84159.1 - 0.15 12.2 0.1 0.32 11.2 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4145) DUF2397 PF09660.10 AIF84164.1 - 0.023 13.6 0.1 0.03 13.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) DUF489 PF04356.12 AIF84166.1 - 0.2 11.7 4.7 0.41 10.6 0.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF489) DUF1018 PF06252.12 AIF84166.1 - 1.1 10.3 8.2 0.99 10.4 1.4 3.3 2 2 0 3 3 3 0 Protein of unknown function (DUF1018) TMP_2 PF06791.13 AIF84166.1 - 1.2 8.8 34.7 0.24 11.1 0.3 5.1 2 2 2 4 4 4 0 Prophage tail length tape measure protein LMBR1 PF04791.16 AIF84166.1 - 1.6 7.6 4.6 2 7.3 0.3 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein PCP_red PF08369.10 AIF84166.1 - 4.4 7.6 5.9 0.73 10.1 0.1 2.7 3 0 0 3 3 3 0 Proto-chlorophyllide reductase 57 kD subunit DUF5615 PF18480.1 AIF84170.1 - 8.3e-12 44.7 0.0 1.5e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5615) zf-C2H2_4 PF13894.6 AIF84170.1 - 0.0099 16.6 2.9 0.12 13.2 0.6 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 AIF84170.1 - 0.011 16.1 0.2 0.025 15.0 0.2 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type PIN_10 PF18478.1 AIF84170.1 - 0.02 15.1 0.0 0.035 14.3 0.0 1.3 1 0 0 1 1 1 0 PIN like domain Mut7-C PF01927.16 AIF84170.1 - 0.24 11.5 3.1 0.73 9.9 3.1 2.0 1 1 0 1 1 1 0 Mut7-C RNAse domain NinF PF05810.12 AIF84171.1 - 0.0051 16.6 0.3 0.0078 16.1 0.3 1.3 1 0 0 1 1 1 1 NinF protein Phage_integr_3 PF16795.5 AIF84172.1 - 4.6e-10 39.6 0.5 7.6e-10 38.9 0.5 1.4 1 0 0 1 1 1 1 Archaeal phage integrase DUF3836 PF12930.7 AIF84172.1 - 0.051 13.3 0.4 0.1 12.4 0.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF3836) DUF3365 PF11845.8 AIF84172.1 - 0.094 13.0 0.0 10 6.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) DUF2255 PF10012.9 AIF84173.1 - 1.8e-09 37.8 0.1 2.2e-09 37.5 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2255) F420H2_quin_red PF04075.14 AIF84173.1 - 1.3e-08 35.0 0.0 1.3e-08 35.0 0.0 1.1 1 0 0 1 1 1 1 F420H(2)-dependent quinone reductase Bmp PF02608.14 AIF84177.1 - 1.8e-57 194.6 3.4 2.2e-57 194.4 3.4 1.1 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like Peripla_BP_4 PF13407.6 AIF84177.1 - 4.5e-05 23.2 4.7 6.2e-05 22.7 4.2 1.7 1 1 0 1 1 1 1 Periplasmic binding protein domain HATPase_c PF02518.26 AIF84178.1 - 3.4e-28 98.4 0.4 1.2e-27 96.6 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 AIF84178.1 - 2.1e-12 47.4 6.1 2.7e-12 47.0 4.6 1.9 2 1 0 2 2 2 1 Cache domain HisKA PF00512.25 AIF84178.1 - 6.5e-12 45.3 0.1 6.4e-11 42.1 0.1 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 AIF84178.1 - 0.00067 19.5 0.0 0.0021 17.9 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 AIF84178.1 - 0.0076 16.1 0.8 0.034 14.1 0.0 2.3 2 1 0 2 2 2 1 GHKL domain Response_reg PF00072.24 AIF84179.1 - 1.5e-18 67.0 0.0 1.6e-18 66.9 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain CdAMP_rec PF06153.11 AIF84180.1 - 0.1 12.8 0.8 0.31 11.3 0.3 1.9 1 1 1 2 2 2 0 Cyclic-di-AMP receptor tRNA_anti-codon PF01336.25 AIF84181.1 - 5.7e-08 32.6 0.2 7e-08 32.4 0.2 1.1 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain REPA_OB_2 PF16900.5 AIF84181.1 - 0.0018 18.1 0.2 0.0023 17.8 0.2 1.1 1 0 0 1 1 1 1 Replication protein A OB domain PAC2 PF09754.9 AIF84182.1 - 1.3e-41 142.9 0.0 1.6e-41 142.7 0.0 1.0 1 0 0 1 1 1 1 PAC2 family Beta_lactamase3 PF17030.5 AIF84182.1 - 0.18 11.0 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Putative beta-lactamase-like family GST_C_2 PF13410.6 AIF84183.1 - 0.005 16.8 0.4 0.14 12.2 0.1 2.9 2 1 1 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 AIF84183.1 - 0.024 14.9 0.0 0.093 13.0 0.0 2.0 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain YIF1 PF03878.15 AIF84184.1 - 0.016 14.8 0.7 0.024 14.1 0.7 1.3 1 0 0 1 1 1 0 YIF1 7tm_2 PF00002.24 AIF84184.1 - 0.055 12.7 0.9 0.1 11.9 0.9 1.5 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) DUF3983 PF13137.6 AIF84185.1 - 0.066 13.0 1.0 0.39 10.6 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3983) Fur_reg_FbpA PF13076.6 AIF84187.1 - 0.078 12.7 1.0 4.4 7.1 0.0 2.2 2 0 0 2 2 2 0 Fur-regulated basic protein A DUF1059 PF06348.11 AIF84188.1 - 3.7e-20 71.9 1.3 4e-20 71.8 1.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) N36 PF11438.8 AIF84190.1 - 0.39 10.6 3.4 1.6 8.6 0.3 2.3 2 0 0 2 2 2 0 36-mer N-terminal peptide of the N protein (N36) PvlArgDC PF01862.16 AIF84191.1 - 3.5e-59 199.2 0.0 4e-59 199.0 0.0 1.0 1 0 0 1 1 1 1 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) IF3_N PF05198.16 AIF84191.1 - 0.007 16.6 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain zf-C2H2_4 PF13894.6 AIF84192.1 - 6.6e-05 23.4 0.1 9.1e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF84192.1 - 0.001 19.4 0.1 0.0013 19.1 0.1 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 AIF84192.1 - 0.0012 18.8 0.0 0.0015 18.4 0.0 1.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_9 PF16293.5 AIF84192.1 - 0.0024 17.7 0.1 0.0027 17.5 0.1 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 AIF84192.1 - 0.0043 17.4 0.1 0.0043 17.4 0.1 1.0 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 AIF84192.1 - 0.011 16.1 0.1 0.014 15.8 0.1 1.1 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 AIF84192.1 - 0.034 13.9 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-C2H2_3 PF13878.6 AIF84192.1 - 0.038 13.8 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO RAP1 PF07218.11 AIF84192.1 - 0.048 11.9 0.0 0.05 11.9 0.0 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) zf-ribbon_3 PF13248.6 AIF84192.1 - 0.053 12.9 0.1 0.074 12.5 0.1 1.3 1 0 0 1 1 1 0 zinc-ribbon domain zf-C2H2_jaz PF12171.8 AIF84192.1 - 0.054 13.8 0.0 0.12 12.6 0.0 1.6 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 AIF84192.1 - 0.057 13.0 0.1 0.075 12.6 0.1 1.2 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger WYL PF13280.6 AIF84193.1 - 0.0008 19.5 0.0 0.00094 19.3 0.0 1.1 1 0 0 1 1 1 1 WYL domain PIG-S PF10510.9 AIF84196.1 - 0.052 12.4 0.0 0.071 11.9 0.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Epimerase_2 PF02350.19 AIF84197.1 - 8.3e-97 324.1 0.1 9.9e-97 323.9 0.1 1.0 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase Methyltransf_23 PF13489.6 AIF84198.1 - 3.2e-14 53.1 0.0 8.7e-14 51.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF84198.1 - 6.5e-14 52.4 0.0 1.6e-13 51.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF84198.1 - 3e-11 43.3 0.0 5.3e-11 42.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF84198.1 - 1.9e-10 41.2 0.0 4.6e-10 40.0 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF84198.1 - 2e-09 38.1 0.0 3.8e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 AIF84198.1 - 4e-06 26.5 0.0 5.9e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase NodS PF05401.11 AIF84198.1 - 8e-06 25.6 0.0 1.3e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) NNMT_PNMT_TEMT PF01234.17 AIF84198.1 - 2.6e-05 23.6 0.0 5.4e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 NNMT/PNMT/TEMT family MTS PF05175.14 AIF84198.1 - 5.3e-05 22.8 0.0 0.00027 20.5 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 AIF84198.1 - 0.00046 19.6 0.1 0.00088 18.7 0.1 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 AIF84198.1 - 0.02 14.6 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Glyco_transf_4 PF13439.6 AIF84199.1 - 0.00084 19.4 0.1 0.0021 18.1 0.1 1.9 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 AIF84199.1 - 0.03 14.8 0.0 0.068 13.6 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 AIF84199.1 - 0.13 12.2 0.1 0.3 11.1 0.1 1.6 1 1 0 1 1 1 0 Glycosyl transferase 4-like Glyco_transf_4 PF13439.6 AIF84200.1 - 2.2e-10 40.8 0.0 9.3e-10 38.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 AIF84200.1 - 1.3e-07 32.2 0.0 4.1e-07 30.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 AIF84200.1 - 0.0013 19.1 0.0 0.0039 17.6 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 AIF84200.1 - 0.0036 17.3 0.0 0.0071 16.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_4 PF13692.6 AIF84200.1 - 0.017 15.6 0.0 0.038 14.4 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 PIG-L PF02585.17 AIF84200.1 - 0.043 14.4 0.0 0.089 13.4 0.0 1.6 1 0 0 1 1 1 0 GlcNAc-PI de-N-acetylase HxlR PF01638.17 AIF84201.1 - 3.6e-21 74.8 0.6 4.3e-21 74.6 0.6 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix Phage_capsid PF05065.13 AIF84201.1 - 0.037 13.3 0.0 0.046 13.0 0.0 1.1 1 0 0 1 1 1 0 Phage capsid family MarR PF01047.22 AIF84201.1 - 0.048 13.6 0.0 0.081 12.9 0.0 1.4 1 0 0 1 1 1 0 MarR family SHOCT PF09851.9 AIF84202.1 - 1.4e-07 31.0 0.0 1.9e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Short C-terminal domain DUF5381 PF17353.2 AIF84202.1 - 0.32 10.7 1.5 0.44 10.3 1.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5381) FeoB_associated PF12669.7 AIF84203.1 - 0.43 11.0 0.0 0.43 11.0 0.0 2.5 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein Polyketide_cyc2 PF10604.9 AIF84204.1 - 9.2e-16 58.4 0.1 1e-15 58.3 0.1 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIF84204.1 - 1.5e-07 31.6 0.0 3.4e-07 30.5 0.0 1.6 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.13 AIF84204.1 - 0.0023 17.7 0.0 0.0033 17.2 0.0 1.4 1 1 0 1 1 1 1 Carbon monoxide dehydrogenase subunit G (CoxG) DUF2505 PF10698.9 AIF84204.1 - 0.0027 17.8 0.0 0.0084 16.2 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2505) MerC PF03203.14 AIF84205.1 - 0.58 10.6 9.0 0.82 10.1 9.0 1.3 1 0 0 1 1 1 0 MerC mercury resistance protein HTH_45 PF14947.6 AIF84206.1 - 1.4e-06 28.1 1.3 1.7e-06 27.9 1.3 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIF84206.1 - 0.014 15.3 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 MarR family DUF2207 PF09972.9 AIF84207.1 - 0.0019 17.1 0.1 0.0022 16.8 0.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF3139 PF11337.8 AIF84207.1 - 0.015 16.0 1.4 2.5 8.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) SUR7 PF06687.12 AIF84207.1 - 0.017 14.7 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 SUR7/PalI family Sigma_reg_N PF13800.6 AIF84207.1 - 0.023 15.0 4.9 0.54 10.6 2.7 2.1 2 0 0 2 2 2 0 Sigma factor regulator N-terminal CemA PF03040.14 AIF84207.1 - 0.038 13.9 1.0 1.8 8.5 0.0 2.1 2 0 0 2 2 2 0 CemA family EMP70 PF02990.16 AIF84207.1 - 0.047 12.4 0.0 0.26 9.9 0.0 1.8 2 0 0 2 2 2 0 Endomembrane protein 70 DUF4083 PF13314.6 AIF84207.1 - 0.25 11.3 0.1 0.25 11.3 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) Sdh_cyt PF01127.22 AIF84207.1 - 0.43 10.6 5.0 0.63 10.1 5.0 1.3 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Ac76 PF05814.11 AIF84207.1 - 0.64 10.1 5.5 1.2 9.2 0.1 2.1 2 0 0 2 2 2 0 Orf76 (Ac76) SP_C-Propep PF08999.10 AIF84207.1 - 0.66 9.8 3.0 11 5.9 0.0 2.1 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide MpPF26 PF07666.11 AIF84207.1 - 1.8 8.7 10.1 3.1 7.9 5.6 2.1 2 0 0 2 2 2 0 M penetrans paralogue family 26 HATPase_c PF02518.26 AIF84209.1 - 8.5e-29 100.3 0.2 2.1e-28 99.1 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIF84209.1 - 1.2e-13 50.8 1.0 1.2e-13 50.8 1.0 2.3 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain dCache_1 PF02743.18 AIF84209.1 - 3e-06 27.2 2.0 2.9e-05 24.0 0.2 2.5 2 1 1 3 3 3 1 Cache domain HATPase_c_2 PF13581.6 AIF84209.1 - 0.00018 21.4 0.0 0.00093 19.2 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 AIF84209.1 - 0.0048 16.8 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 GHKL domain HATPase_c_3 PF13589.6 AIF84209.1 - 0.032 14.1 0.1 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FliJ PF02050.16 AIF84209.1 - 0.12 12.6 6.1 0.13 12.5 1.8 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein zf-AN1 PF01428.16 AIF84210.1 - 0.71 10.1 11.6 1.2 9.3 11.6 1.6 1 1 0 1 1 1 0 AN1-like Zinc finger Sigma70_r1_1 PF03979.14 AIF84211.1 - 0.0074 16.3 0.0 1.6 8.9 0.0 2.0 1 1 1 2 2 2 2 Sigma-70 factor, region 1.1 LysM PF01476.20 AIF84211.1 - 0.18 11.9 0.0 0.25 11.5 0.0 1.3 1 1 0 1 1 1 0 LysM domain Formyl_trans_N PF00551.19 AIF84213.1 - 4.2e-46 157.0 0.0 5.9e-46 156.5 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase ACT_6 PF13740.6 AIF84213.1 - 1e-08 35.0 0.0 1.9e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 AIF84213.1 - 1.1e-05 26.0 1.3 8e-05 23.2 0.2 2.7 4 0 0 4 4 4 1 ACT domain ACT PF01842.25 AIF84213.1 - 1.7e-05 24.5 0.1 5.4e-05 22.9 0.1 1.9 1 0 0 1 1 1 1 ACT domain Creatininase PF02633.14 AIF84214.1 - 1.6e-63 214.4 0.8 1.9e-63 214.2 0.8 1.0 1 0 0 1 1 1 1 Creatinine amidohydrolase LSM PF01423.22 AIF84215.1 - 3.6e-23 81.0 1.3 4e-23 80.9 1.3 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AIF84215.1 - 0.0012 19.0 0.1 0.0014 18.7 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF150_C PF17384.2 AIF84215.1 - 0.086 13.0 0.1 0.12 12.5 0.1 1.3 1 1 0 1 1 1 0 RimP C-terminal SH3 domain Ribosomal_L37e PF01907.19 AIF84216.1 - 5.6e-23 80.9 14.0 6e-23 80.8 14.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L37e HypA PF01155.19 AIF84216.1 - 0.00046 20.2 0.8 0.00048 20.1 0.8 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 AIF84216.1 - 0.0048 16.9 1.2 0.0057 16.6 1.2 1.2 1 0 0 1 1 1 1 Double zinc ribbon Ribosomal_S14 PF00253.21 AIF84216.1 - 0.0078 15.9 0.5 0.0078 15.9 0.5 2.1 1 1 1 2 2 2 1 Ribosomal protein S14p/S29e Ephrin_rec_like PF07699.13 AIF84216.1 - 0.0085 15.8 1.6 0.013 15.2 1.6 1.4 1 0 0 1 1 1 1 Putative ephrin-receptor like zf-ribbon_3 PF13248.6 AIF84216.1 - 0.009 15.4 2.3 0.46 10.0 0.1 2.1 2 0 0 2 2 2 2 zinc-ribbon domain Rubredoxin_2 PF18073.1 AIF84216.1 - 0.032 13.9 4.7 1.9 8.3 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain DNA_RNApol_7kD PF03604.13 AIF84216.1 - 0.045 13.4 3.5 0.045 13.4 3.5 2.2 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zn-ribbon_14 PF16503.5 AIF84216.1 - 0.066 12.7 6.3 1.1 8.8 0.9 2.2 2 0 0 2 2 2 0 Zinc-ribbon NRDD PF13597.6 AIF84216.1 - 0.068 11.9 2.7 0.064 12.0 2.7 1.0 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase zinc_ribbon_13 PF09855.9 AIF84216.1 - 0.11 12.7 3.6 3 8.1 0.3 2.2 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-Mss51 PF13824.6 AIF84216.1 - 0.17 12.0 4.9 12 6.1 4.9 2.1 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zinc_ribbon_4 PF13717.6 AIF84216.1 - 0.19 11.7 7.6 0.59 10.1 0.8 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 AIF84216.1 - 0.27 11.0 7.3 0.9 9.4 7.3 1.8 1 1 0 1 1 1 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIF84216.1 - 0.54 10.2 7.1 0.78 9.7 7.0 1.4 1 1 0 1 1 1 0 Putative transposase DNA-binding domain DUF35_N PF12172.8 AIF84216.1 - 0.71 9.8 7.3 1.2 9.1 7.3 1.3 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) UPF0547 PF10571.9 AIF84216.1 - 2.6 8.2 6.7 9.6 6.4 1.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Mu-like_Pro PF10123.9 AIF84217.1 - 0.073 12.6 10.5 0.027 14.0 7.7 1.6 1 1 0 1 1 1 0 Mu-like prophage I protein MutS_III PF05192.18 AIF84217.1 - 1.5 9.0 5.2 1.2 9.3 3.9 1.4 1 1 0 1 1 1 0 MutS domain III Matrilin_ccoil PF10393.9 AIF84217.1 - 3.7 7.5 7.3 2.1 8.2 0.1 3.1 2 1 1 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Uds1 PF15456.6 AIF84217.1 - 5 7.3 14.2 0.66 10.1 4.5 2.9 1 1 0 2 2 2 0 Up-regulated During Septation Asn_synthase PF00733.21 AIF84218.1 - 2.1e-27 96.7 0.0 2.8e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.17 AIF84218.1 - 0.0033 16.6 0.0 0.0053 15.9 0.0 1.4 1 0 0 1 1 1 1 NAD synthase tRNA_Me_trans PF03054.16 AIF84218.1 - 0.029 13.2 0.0 0.051 12.4 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase QueC PF06508.13 AIF84218.1 - 0.064 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Glycos_transf_2 PF00535.26 AIF84219.1 - 3.7e-18 65.9 0.3 5.7e-18 65.3 0.3 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIF84219.1 - 3.3e-06 27.2 0.1 2.6e-05 24.2 0.1 1.9 1 1 1 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AIF84219.1 - 0.0013 19.2 0.1 0.0028 18.1 0.1 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 AIF84219.1 - 0.023 14.2 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 TrmK PF04816.12 AIF84220.1 - 0.03 13.9 0.2 0.04 13.5 0.2 1.1 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase DUF4381 PF14316.6 AIF84220.1 - 0.037 14.3 1.4 0.078 13.2 1.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4381) THF_DHG_CYH_C PF02882.19 AIF84221.1 - 1.5e-64 216.1 0.6 2.1e-64 215.7 0.6 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 AIF84221.1 - 1.7e-39 134.7 0.2 2.6e-39 134.1 0.2 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Shikimate_DH PF01488.20 AIF84221.1 - 0.00071 19.6 0.2 0.0024 17.9 0.1 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 AIF84221.1 - 0.0029 18.1 0.1 0.011 16.2 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 AIF84221.1 - 0.0032 16.8 0.3 0.0068 15.7 0.1 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain OCD_Mu_crystall PF02423.15 AIF84221.1 - 0.0039 16.2 0.1 0.0072 15.3 0.1 1.4 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family 5-FTHF_cyc-lig PF01812.20 AIF84222.1 - 8.8e-36 123.5 0.0 9.7e-36 123.4 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family GARS_A PF01071.19 AIF84223.1 - 3.7e-78 261.7 0.5 5.2e-78 261.3 0.5 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 AIF84223.1 - 5.9e-31 107.1 0.2 2.4e-30 105.2 0.0 2.0 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 AIF84223.1 - 7.8e-28 96.6 2.4 1.2e-27 96.0 1.2 2.0 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_3 PF02655.14 AIF84223.1 - 1e-06 28.9 0.0 2e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 AIF84223.1 - 0.00017 21.2 0.1 0.00046 19.8 0.1 1.7 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 AIF84223.1 - 0.00024 20.8 0.0 0.00082 19.0 0.1 1.8 2 0 0 2 2 2 1 RimK-like ATP-grasp domain CPSase_L_D2 PF02786.17 AIF84223.1 - 0.00079 19.0 0.3 0.0045 16.5 0.3 2.0 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_ST PF14397.6 AIF84223.1 - 0.0016 17.8 0.1 0.017 14.4 0.1 2.2 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp Dala_Dala_lig_C PF07478.13 AIF84223.1 - 0.0055 16.3 0.0 0.0091 15.6 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_2 PF08442.10 AIF84223.1 - 0.0092 15.6 0.3 0.028 14.0 0.3 1.7 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.6 AIF84223.1 - 0.084 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain SWIM PF04434.17 AIF84224.1 - 0.0025 17.5 0.2 0.0039 16.8 0.2 1.3 1 0 0 1 1 1 1 SWIM zinc finger Metallophos_2 PF12850.7 AIF84225.1 - 3.8e-09 37.0 0.1 5.8e-09 36.4 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 AIF84225.1 - 1.2e-08 35.7 0.9 1.2e-07 32.4 0.9 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase CPSase_L_D2 PF02786.17 AIF84226.1 - 6.5e-107 355.8 0.0 5.6e-74 248.2 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 AIF84226.1 - 3.1e-39 134.1 0.0 6.3e-39 133.1 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 AIF84226.1 - 8.8e-14 51.4 0.3 6.9e-07 29.0 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.22 AIF84226.1 - 1.1e-13 51.2 0.2 7.1e-13 48.6 0.0 2.5 3 0 0 3 3 3 1 MGS-like domain Dala_Dala_lig_C PF07478.13 AIF84226.1 - 4.9e-13 49.1 0.2 2.7e-09 36.9 0.0 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 AIF84226.1 - 1.2e-11 44.4 0.0 5.7e-08 32.6 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.19 AIF84226.1 - 5.6e-06 26.3 0.1 0.00021 21.1 0.0 2.8 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.14 AIF84226.1 - 0.0013 18.8 0.1 0.03 14.4 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_5 PF13549.6 AIF84226.1 - 0.0015 18.0 0.0 0.58 9.6 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.11 AIF84226.1 - 0.0083 15.7 0.0 0.45 10.1 0.0 2.6 2 1 0 2 2 2 1 RimK-like ATP-grasp domain CPSase_sm_chain PF00988.22 AIF84227.1 - 4.1e-49 165.7 0.0 6.5e-49 165.0 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 AIF84227.1 - 4e-44 150.7 0.0 8.1e-44 149.7 0.0 1.5 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIF84227.1 - 4.6e-09 36.4 0.4 0.00058 19.7 0.1 2.3 1 1 1 2 2 2 2 Peptidase C26 Iso_dh PF00180.20 AIF84229.1 - 3e-98 329.2 0.3 3.4e-98 329.0 0.3 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PdxA PF04166.12 AIF84229.1 - 0.017 14.5 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthetic protein PdxA GerE PF00196.19 AIF84229.1 - 0.39 10.3 1.9 22 4.7 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HMGL-like PF00682.19 AIF84230.1 - 2.3e-89 299.4 3.5 2.3e-89 299.4 3.5 1.7 2 0 0 2 2 2 1 HMGL-like LeuA_dimer PF08502.10 AIF84230.1 - 2.8e-31 108.2 2.5 6.5e-31 107.0 2.5 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain ALS_ss_C PF10369.9 AIF84231.1 - 1.4e-28 98.9 1.5 2e-26 92.0 0.0 3.0 2 1 0 2 2 2 1 Small subunit of acetolactate synthase ACT_5 PF13710.6 AIF84231.1 - 3e-18 65.4 0.6 6.3e-18 64.4 0.6 1.6 1 0 0 1 1 1 1 ACT domain ACT PF01842.25 AIF84231.1 - 6.8e-17 60.9 0.1 1.4e-16 60.0 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 AIF84231.1 - 6.6e-07 29.8 0.6 1.4e-06 28.8 0.6 1.5 1 0 0 1 1 1 1 ACT domain NIL PF09383.10 AIF84231.1 - 0.0024 17.7 0.4 0.32 10.9 0.1 2.3 2 0 0 2 2 2 1 NIL domain Saccharop_dh_N PF04455.12 AIF84231.1 - 0.011 16.1 0.4 0.023 15.1 0.3 1.5 1 1 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region ACT_6 PF13740.6 AIF84231.1 - 0.076 13.0 0.2 1.4 8.9 0.1 2.3 2 0 0 2 2 2 0 ACT domain NCD2 PF04905.13 AIF84231.1 - 0.086 12.8 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) TPP_enzyme_N PF02776.18 AIF84232.1 - 3.6e-61 205.7 0.4 5.6e-60 201.9 0.0 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AIF84232.1 - 1.1e-48 164.5 0.1 2.4e-48 163.3 0.1 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AIF84232.1 - 5.8e-45 152.8 0.4 1e-43 148.8 0.4 2.7 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain SnoaL_3 PF13474.6 AIF84233.1 - 3.7e-11 43.3 0.0 4.4e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIF84233.1 - 0.00011 22.6 0.0 0.00013 22.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_4 PF13577.6 AIF84233.1 - 0.0036 17.4 0.0 0.0043 17.2 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain Lumazine_bd_2 PF12893.7 AIF84233.1 - 0.036 14.7 0.2 0.07 13.8 0.0 1.5 1 1 0 1 1 1 0 Putative lumazine-binding CaMKII_AD PF08332.10 AIF84233.1 - 0.04 14.0 0.0 0.055 13.6 0.0 1.2 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain DUF3804 PF12707.7 AIF84233.1 - 0.08 12.7 0.2 0.14 11.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3804) DeoC PF01791.9 AIF84234.1 - 1.5e-20 73.8 0.1 4.4e-20 72.3 0.0 1.7 2 0 0 2 2 2 1 DeoC/LacD family aldolase SseB_C PF14581.6 AIF84234.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 SseB protein C-terminal domain ADH_N PF08240.12 AIF84235.1 - 6.9e-24 83.8 1.6 1.2e-23 83.0 1.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIF84235.1 - 2e-22 79.5 0.1 4.8e-22 78.3 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AIF84235.1 - 1.7e-10 40.8 0.0 2.5e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 AIF84235.1 - 8.1e-05 23.7 0.0 0.00013 23.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 AIF84235.1 - 0.0032 16.8 0.2 0.32 10.2 0.0 2.2 1 1 1 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 AIF84235.1 - 0.076 11.7 0.1 0.13 11.0 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein F5_F8_type_C PF00754.25 AIF84236.1 - 6.1e-16 58.7 2.8 6.1e-16 58.7 2.8 2.9 4 1 1 5 5 5 1 F5/8 type C domain HYR PF02494.16 AIF84236.1 - 0.013 15.9 0.1 0.11 12.9 0.0 2.4 2 0 0 2 2 2 0 HYR domain Sad1_UNC PF07738.13 AIF84236.1 - 0.12 12.4 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal zf-C2H2_4 PF13894.6 AIF84238.1 - 0.00019 22.0 0.3 0.00029 21.4 0.3 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF84238.1 - 0.0011 19.3 0.3 0.002 18.5 0.3 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 AIF84238.1 - 0.0023 17.9 0.3 0.0035 17.3 0.3 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 AIF84238.1 - 0.017 15.4 0.0 0.017 15.4 0.0 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 AIF84238.1 - 0.034 13.8 0.1 0.044 13.4 0.1 1.2 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_4 PF13717.6 AIF84238.1 - 0.046 13.7 0.7 0.076 12.9 0.5 1.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2_jaz PF12171.8 AIF84238.1 - 0.053 13.8 0.1 0.077 13.3 0.1 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Desulfoferrod_N PF06397.12 AIF84238.1 - 0.081 12.6 0.1 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain zf-H2C2_2 PF13465.6 AIF84238.1 - 2.6 8.6 7.7 0.18 12.3 2.9 1.6 2 0 0 2 2 2 0 Zinc-finger double domain KAP PF05804.12 AIF84239.1 - 0.022 12.9 0.0 0.022 12.9 0.0 1.0 1 0 0 1 1 1 0 Kinesin-associated protein (KAP) HTH_3 PF01381.22 AIF84240.1 - 1.3e-05 25.1 0.2 4.1e-05 23.5 0.1 1.8 2 0 0 2 2 2 1 Helix-turn-helix HTH_37 PF13744.6 AIF84240.1 - 0.0018 18.2 0.0 0.0045 16.9 0.0 1.7 1 1 1 2 2 2 1 Helix-turn-helix domain YdaS_antitoxin PF15943.5 AIF84240.1 - 0.0033 17.3 0.0 0.007 16.2 0.0 1.7 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_19 PF12844.7 AIF84240.1 - 0.0036 17.3 0.2 0.033 14.2 0.1 2.1 1 1 1 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 AIF84240.1 - 0.02 14.8 0.0 2.4 8.1 0.0 2.4 2 0 0 2 2 2 0 MarR family P22_Cro PF14549.6 AIF84240.1 - 0.024 14.5 0.0 0.062 13.1 0.0 1.8 2 0 0 2 2 2 0 DNA-binding transcriptional regulator Cro Sigma70_r4_2 PF08281.12 AIF84240.1 - 0.046 13.4 0.1 0.2 11.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_17 PF12728.7 AIF84240.1 - 0.095 12.9 0.0 0.24 11.6 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_26 PF13443.6 AIF84240.1 - 0.11 13.0 0.1 0.25 11.8 0.1 1.7 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain Cro PF09048.10 AIF84240.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Cro Phage_holin_3_6 PF07332.11 AIF84241.1 - 1.6e-05 24.9 0.9 1.9e-05 24.7 0.9 1.0 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III DUF998 PF06197.13 AIF84241.1 - 7e-05 22.5 1.8 7.5e-05 22.4 1.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF998) DUF3185 PF11381.8 AIF84241.1 - 0.0085 16.1 0.2 0.16 12.0 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3185) DUF3043 PF11241.8 AIF84241.1 - 0.014 15.5 0.0 0.014 15.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Wzy_C PF04932.15 AIF84241.1 - 0.051 13.2 0.1 0.057 13.0 0.1 1.1 1 0 0 1 1 1 0 O-Antigen ligase DUF4131 PF13567.6 AIF84241.1 - 0.052 13.2 0.2 0.062 13.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2207 PF09972.9 AIF84241.1 - 0.072 11.8 0.1 0.075 11.8 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF202 PF02656.15 AIF84241.1 - 0.17 12.3 8.5 2.4 8.6 8.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF2905 PF11146.8 AIF84241.1 - 0.22 11.7 2.6 9.8 6.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2905) SdpI PF13630.6 AIF84241.1 - 1.2 9.4 4.1 1.6 8.9 4.1 1.2 1 0 0 1 1 1 0 SdpI/YhfL protein family PEP-CTERM PF07589.11 AIF84241.1 - 1.4 9.1 6.4 3.2 8.0 0.1 2.2 2 0 0 2 2 2 0 PEP-CTERM motif HTH_20 PF12840.7 AIF84242.1 - 2.3e-07 30.8 0.0 4.4e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_45 PF14947.6 AIF84242.1 - 3.5e-06 26.9 0.1 9.1e-06 25.6 0.1 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix MarR_2 PF12802.7 AIF84242.1 - 6.1e-06 26.0 0.1 3.7e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 MarR family DUF4423 PF14394.6 AIF84242.1 - 3.1e-05 23.7 0.1 5.7e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) HTH_5 PF01022.20 AIF84242.1 - 0.00096 19.0 0.2 0.0025 17.6 0.2 1.8 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family TrmB PF01978.19 AIF84242.1 - 0.0017 18.2 0.0 0.0079 16.1 0.0 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 AIF84242.1 - 0.0023 18.4 0.0 0.0046 17.4 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_11 PF08279.12 AIF84242.1 - 0.0062 16.5 0.1 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 AIF84242.1 - 0.0064 16.4 0.5 0.019 14.9 0.1 1.9 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.6 AIF84242.1 - 0.0068 15.9 0.2 0.016 14.7 0.2 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding FtsK_gamma PF09397.10 AIF84242.1 - 0.018 14.9 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 Ftsk gamma domain Fe_dep_repress PF01325.19 AIF84242.1 - 0.028 14.6 0.1 0.097 12.9 0.0 1.9 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain DUF2250 PF10007.9 AIF84242.1 - 0.032 14.3 0.2 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) Regulator_TrmB PF11495.8 AIF84242.1 - 0.047 12.9 0.0 0.065 12.4 0.0 1.2 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB HTH_Crp_2 PF13545.6 AIF84242.1 - 0.05 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Mrr_N PF14338.6 AIF84242.1 - 0.057 13.6 0.0 0.32 11.2 0.0 2.2 2 1 0 2 2 2 0 Mrr N-terminal domain DUF1724 PF08350.10 AIF84242.1 - 0.1 12.8 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1724) HTH_IclR PF09339.10 AIF84242.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain XRCC4 PF06632.12 AIF84242.1 - 0.24 10.2 1.4 0.25 10.2 0.3 1.5 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 RibD_C PF01872.17 AIF84243.1 - 6.2e-24 84.9 0.0 7.1e-24 84.7 0.0 1.1 1 0 0 1 1 1 1 RibD C-terminal domain DHFR_1 PF00186.19 AIF84243.1 - 0.0012 18.6 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Dihydrofolate reductase DUF1801 PF08818.11 AIF84244.1 - 1.7e-21 76.5 0.0 2.1e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DU1801) zf_C2H2_10 PF18414.1 AIF84245.1 - 0.014 14.9 0.3 0.022 14.3 0.3 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger zf-C2H2_4 PF13894.6 AIF84245.1 - 0.018 15.9 0.1 0.034 15.0 0.1 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF84245.1 - 0.028 14.9 0.1 0.052 14.0 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf_C2H2_ZHX PF18387.1 AIF84245.1 - 0.032 13.9 0.1 0.074 12.7 0.1 1.7 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Pyr_redox_2 PF07992.14 AIF84246.1 - 1.9e-50 171.8 0.2 2.6e-50 171.3 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 AIF84246.1 - 3.4e-26 91.7 0.1 8.7e-26 90.3 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 AIF84246.1 - 8.8e-14 51.8 1.1 4.4e-11 43.2 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AIF84246.1 - 8.3e-11 41.7 0.3 2.3e-08 33.7 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 AIF84246.1 - 2.6e-06 26.8 0.1 7.1e-05 22.1 0.0 2.6 2 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 AIF84246.1 - 0.00046 19.4 2.2 0.0032 16.6 0.6 2.6 2 1 1 3 3 3 1 FAD binding domain GIDA PF01134.22 AIF84246.1 - 0.0015 17.7 1.7 0.0019 17.4 0.1 2.0 2 1 1 3 3 3 1 Glucose inhibited division protein A 3HCDH_N PF02737.18 AIF84246.1 - 0.004 17.1 0.4 0.099 12.5 0.0 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 AIF84246.1 - 0.18 10.5 0.6 0.52 9.0 0.2 1.9 2 0 0 2 2 2 0 HI0933-like protein RNA_pol_Rpb6 PF01192.22 AIF84247.1 - 1.5e-08 34.4 1.4 2.7e-08 33.6 0.0 2.0 2 1 0 2 2 2 1 RNA polymerase Rpb6 Cyclophil_like PF04126.13 AIF84248.1 - 9.6e-09 35.1 0.0 1.3e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin-like Cyclophil_like2 PF18050.1 AIF84248.1 - 5e-06 26.4 0.0 6.5e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin-like family DUF3830 PF12903.7 AIF84248.1 - 0.029 14.1 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3830) DUF2859 PF11072.8 AIF84248.1 - 0.11 12.3 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2859) Cupin_3 PF05899.12 AIF84248.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Ribosomal_S25 PF03297.15 AIF84249.1 - 2.7e-10 40.4 5.4 3.4e-10 40.0 5.4 1.2 1 0 0 1 1 1 1 S25 ribosomal protein TrmB PF01978.19 AIF84249.1 - 0.0026 17.6 0.2 0.0037 17.1 0.2 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 AIF84249.1 - 0.011 15.7 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 AIF84249.1 - 0.013 15.1 0.1 0.022 14.3 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 AIF84249.1 - 0.047 14.0 0.4 0.064 13.6 0.4 1.3 1 0 0 1 1 1 0 Transcriptional regulator MarR_2 PF12802.7 AIF84249.1 - 0.082 12.8 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 MarR family DUF4320 PF14208.6 AIF84249.1 - 0.089 12.9 0.3 0.22 11.6 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) HTH_IclR PF09339.10 AIF84249.1 - 0.14 12.0 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 IclR helix-turn-helix domain DNA_ligase_A_M PF01068.21 AIF84250.1 - 9.6e-57 191.9 0.2 1.8e-56 191.0 0.2 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 AIF84250.1 - 1.4e-33 116.7 0.2 4.1e-33 115.1 0.0 1.8 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 AIF84250.1 - 1.1e-19 70.8 0.0 3e-19 69.5 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 AIF84250.1 - 6.3e-09 36.3 0.0 1.3e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 RNA ligase 2-Hacid_dh_C PF02826.19 AIF84253.1 - 2e-46 157.6 0.0 2.4e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 AIF84254.1 - 3.3e-13 49.4 0.0 3.9e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_1 PF00175.21 AIF84256.1 - 2.7e-22 79.5 0.0 5.1e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Rieske PF00355.26 AIF84256.1 - 5.6e-15 55.0 0.0 1.3e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain FAD_binding_6 PF00970.24 AIF84256.1 - 2.6e-06 27.7 0.0 4.8e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Rieske_2 PF13806.6 AIF84256.1 - 4.4e-05 23.4 0.0 9.7e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain NAD_binding_6 PF08030.12 AIF84256.1 - 0.00036 20.7 0.0 0.061 13.5 0.0 2.4 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Ferritin PF00210.24 AIF84257.1 - 6.1e-25 87.8 0.7 7.7e-25 87.5 0.7 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 AIF84257.1 - 0.00014 22.2 2.4 0.00045 20.6 2.5 1.7 1 1 0 1 1 1 1 Rubrerythrin Ferritin-like PF12902.7 AIF84257.1 - 0.015 15.2 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Ferritin-like PAC2 PF09754.9 AIF84259.1 - 2.2e-25 89.9 0.0 2.7e-25 89.6 0.0 1.0 1 0 0 1 1 1 1 PAC2 family E1-E2_ATPase PF00122.20 AIF84261.1 - 3.3e-54 183.2 3.3 7.9e-54 181.9 3.3 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 AIF84261.1 - 1.8e-49 168.9 3.5 3.3e-49 168.0 3.5 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 AIF84261.1 - 1.1e-26 93.0 0.2 7.8e-16 58.3 0.4 3.2 2 0 0 2 2 2 2 Heavy-metal-associated domain HAD PF12710.7 AIF84261.1 - 4.1e-06 27.3 0.1 4.3e-05 24.0 0.1 2.6 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 AIF84261.1 - 0.00011 22.2 0.0 0.0079 16.3 0.0 3.2 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AIF84261.1 - 0.00021 21.2 4.4 0.05 13.3 1.7 2.9 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase PCP_red PF08369.10 AIF84261.1 - 0.013 15.7 0.2 0.037 14.2 0.2 1.8 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit HAD_2 PF13419.6 AIF84261.1 - 0.039 14.1 0.0 0.29 11.2 0.0 2.5 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF5593 PF18007.1 AIF84262.1 - 0.024 15.3 0.0 0.027 15.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5593) Arginase PF00491.21 AIF84264.1 - 3.8e-61 207.0 0.3 4.4e-61 206.8 0.3 1.0 1 0 0 1 1 1 1 Arginase family ECH_1 PF00378.20 AIF84265.1 - 9e-59 198.8 4.9 3.1e-55 187.2 3.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 AIF84265.1 - 2.1e-40 139.2 1.9 7.8e-38 130.8 0.6 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 AIF84265.1 - 0.044 13.7 0.0 0.27 11.2 0.0 2.1 2 0 0 2 2 2 0 Peptidase family S49 GHMP_kinases_N PF00288.26 AIF84266.1 - 5.6e-13 48.9 2.3 1.4e-12 47.6 2.3 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AIF84266.1 - 3.1e-08 33.9 0.1 5.9e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 GHMP kinases C terminal ATP_bind_1 PF03029.17 AIF84267.1 - 6.9e-53 179.9 0.0 7.7e-53 179.7 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 AIF84267.1 - 0.0024 18.1 0.1 0.0065 16.8 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AIF84267.1 - 0.0032 17.9 0.1 0.0088 16.4 0.1 2.0 1 1 1 2 2 2 1 AAA ATPase domain CLP1_P PF16575.5 AIF84267.1 - 0.0069 16.2 0.0 1.6 8.5 0.0 2.4 2 0 0 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 AIF84267.1 - 0.0099 16.0 0.0 0.17 11.9 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 AIF84267.1 - 0.012 14.7 0.1 0.04 12.9 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 AIF84267.1 - 0.013 14.8 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 AIF84267.1 - 0.048 14.2 0.2 0.11 13.0 0.1 1.8 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 AIF84267.1 - 0.098 12.2 0.3 6.6 6.3 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 AIF84267.1 - 0.19 12.0 0.1 2.7 8.2 0.1 2.2 2 0 0 2 2 2 0 AAA domain LPG_synthase_TM PF03706.13 AIF84269.1 - 2.4e-26 93.0 23.6 3.4e-26 92.5 23.6 1.2 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region HemY_N PF07219.13 AIF84269.1 - 0.12 12.6 0.1 0.12 12.6 0.1 2.6 3 1 0 3 3 3 0 HemY protein N-terminus Snf7 PF03357.21 AIF84271.1 - 9.9e-08 31.8 0.2 1.6e-07 31.1 0.2 1.3 1 0 0 1 1 1 1 Snf7 LOH1CR12 PF10158.9 AIF84271.1 - 0.0028 17.7 0.3 0.0046 17.0 0.3 1.3 1 0 0 1 1 1 1 Tumour suppressor protein Proteasom_PSMB PF10508.9 AIF84271.1 - 0.015 13.8 0.9 0.02 13.4 0.9 1.1 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit Atg14 PF10186.9 AIF84271.1 - 0.037 13.1 0.9 0.047 12.8 0.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2884 PF11101.8 AIF84271.1 - 0.041 13.4 3.3 0.063 12.8 2.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2884) Uso1_p115_C PF04871.13 AIF84271.1 - 0.066 13.6 1.1 0.11 12.9 1.1 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region IFT57 PF10498.9 AIF84271.1 - 0.16 10.9 4.5 0.22 10.4 4.5 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 SOAR PF16533.5 AIF84271.1 - 0.16 11.9 3.8 0.22 11.5 3.0 1.6 2 0 0 2 2 2 0 STIM1 Orai1-activating region Nup88 PF10168.9 AIF84271.1 - 0.55 8.0 4.2 0.78 7.5 4.2 1.1 1 0 0 1 1 1 0 Nuclear pore component FOXP-CC PF16159.5 AIF84271.1 - 1.5 9.6 3.4 1.3 9.7 1.1 1.9 1 1 1 2 2 2 0 FOXP coiled-coil domain CopG_antitoxin PF12441.8 AIF84272.1 - 3.8e-05 24.1 0.1 0.00011 22.6 0.0 1.9 2 0 0 2 2 2 1 CopG antitoxin of type II toxin-antitoxin system Cloacin_immun PF03513.14 AIF84272.1 - 0.029 14.7 0.1 0.12 12.8 0.1 2.0 2 0 0 2 2 2 0 Cloacin immunity protein ADH_zinc_N PF00107.26 AIF84275.1 - 1.2e-29 103.0 0.3 1.8e-29 102.3 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AIF84275.1 - 7.2e-25 87.0 0.0 1.2e-24 86.2 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 AIF84275.1 - 2.3e-15 57.8 0.0 4e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_16 PF10294.9 AIF84275.1 - 0.024 14.4 0.1 0.036 13.8 0.1 1.2 1 0 0 1 1 1 0 Lysine methyltransferase SIS PF01380.22 AIF84277.1 - 8.9e-52 174.4 4.0 2.6e-26 92.0 0.9 2.8 3 0 0 3 3 3 2 SIS domain GATase_6 PF13522.6 AIF84277.1 - 5.5e-21 75.2 0.0 1.1e-20 74.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AIF84277.1 - 1.9e-15 56.8 0.0 4.4e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 AIF84277.1 - 1.9e-05 24.7 4.1 0.0016 18.5 0.1 3.4 2 2 1 3 3 3 2 SIS domain GATase_4 PF13230.6 AIF84277.1 - 0.0002 20.4 0.0 0.00034 19.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II S_layer_C PF05124.12 AIF84278.1 - 1.8e-10 41.2 0.0 3.3e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 S-layer like family, C-terminal region HTH_20 PF12840.7 AIF84278.1 - 5.9e-09 35.9 0.0 9.9e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 AIF84278.1 - 4.1e-05 23.4 0.1 8e-05 22.5 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 AIF84278.1 - 0.0079 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 MarR family HTH_5 PF01022.20 AIF84278.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family DUF4862 PF16154.5 AIF84278.1 - 0.036 13.4 0.0 0.054 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4862) BcsB PF03170.13 AIF84278.1 - 0.039 12.3 0.0 0.065 11.6 0.0 1.3 1 1 0 1 1 1 0 Bacterial cellulose synthase subunit HTH_29 PF13551.6 AIF84278.1 - 0.084 12.9 0.2 0.33 11.0 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn helix DUF2250 PF10007.9 AIF84278.1 - 0.14 12.3 0.0 0.34 11.0 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) S4 PF01479.25 AIF84279.1 - 2.7e-12 46.2 4.9 2.6e-11 43.1 0.2 2.9 3 0 0 3 3 3 2 S4 domain Ribosomal_S4 PF00163.19 AIF84279.1 - 6.4e-05 23.8 2.1 8.1e-05 23.5 0.5 1.9 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain Ribosomal_S13 PF00416.22 AIF84280.1 - 1.1e-38 132.5 0.1 1.4e-38 132.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Bac_small_YrzI PF09501.10 AIF84281.1 - 0.045 13.9 0.1 0.052 13.7 0.1 1.1 1 0 0 1 1 1 0 Probable sporulation protein (Bac_small_yrzI) SH3BP5 PF05276.14 AIF84282.1 - 6.7e-05 22.8 0.4 0.00013 21.9 0.4 1.4 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) TolA_bind_tri PF16331.5 AIF84282.1 - 0.00017 21.6 2.7 0.0031 17.6 0.5 2.4 2 0 0 2 2 2 1 TolA binding protein trimerisation PspA_IM30 PF04012.12 AIF84282.1 - 0.00059 19.5 0.7 0.00059 19.5 0.7 2.2 1 1 1 2 2 2 1 PspA/IM30 family Laminin_II PF06009.12 AIF84282.1 - 0.0037 17.3 9.7 0.15 12.1 3.0 2.7 1 1 1 2 2 2 2 Laminin Domain II DUF3958 PF13125.6 AIF84282.1 - 0.0054 16.9 0.9 0.0054 16.9 0.9 2.3 1 1 2 3 3 3 1 Protein of unknown function (DUF3958) WEMBL PF05701.11 AIF84282.1 - 0.008 14.9 13.0 0.015 14.1 13.0 1.5 1 1 0 1 1 1 1 Weak chloroplast movement under blue light FlpD PF02662.16 AIF84282.1 - 0.012 15.6 2.7 3.3 7.7 0.0 3.1 2 1 1 3 3 3 0 Methyl-viologen-reducing hydrogenase, delta subunit HMMR_C PF15908.5 AIF84282.1 - 0.013 15.7 0.6 0.013 15.7 0.6 2.6 1 1 1 3 3 3 0 Hyaluronan mediated motility receptor C-terminal YscO PF07321.12 AIF84282.1 - 0.034 14.1 0.9 0.034 14.1 0.9 2.6 2 1 0 2 2 2 0 Type III secretion protein YscO DUF2730 PF10805.8 AIF84282.1 - 0.038 14.1 0.7 0.038 14.1 0.7 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) Arm-DNA-bind_2 PF12167.8 AIF84282.1 - 0.038 13.9 0.1 0.45 10.5 0.0 2.4 2 0 0 2 2 2 0 Arm DNA-binding domain CorA PF01544.18 AIF84282.1 - 0.067 12.5 3.3 0.11 11.8 3.3 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein LPP PF04728.13 AIF84282.1 - 0.082 13.3 4.2 3.7 8.0 0.1 3.9 4 0 0 4 4 4 0 Lipoprotein leucine-zipper Cauli_AT PF03233.13 AIF84282.1 - 0.17 11.8 9.2 0.089 12.7 4.1 2.1 2 0 0 2 2 2 0 Aphid transmission protein DUF2203 PF09969.9 AIF84282.1 - 0.26 12.0 10.8 2 9.2 3.4 2.3 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Baculo_PEP_C PF04513.12 AIF84282.1 - 0.27 11.3 2.3 0.79 9.8 0.8 2.1 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus V_ATPase_I PF01496.19 AIF84282.1 - 0.31 8.9 4.0 0.31 8.9 3.4 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family SlyX PF04102.12 AIF84282.1 - 0.34 11.6 4.5 1.4 9.5 0.3 3.5 3 1 1 4 4 3 0 SlyX Noelin-1 PF12308.8 AIF84282.1 - 0.35 10.9 2.9 0.26 11.3 0.9 1.8 2 0 0 2 2 2 0 Neurogenesis glycoprotein DivIC PF04977.15 AIF84282.1 - 0.4 10.5 12.0 0.24 11.2 3.5 3.8 4 1 0 4 4 4 0 Septum formation initiator DUF4446 PF14584.6 AIF84282.1 - 0.41 10.6 6.9 3.9 7.4 0.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) Prefoldin PF02996.17 AIF84282.1 - 0.43 10.5 9.1 0.68 9.9 0.3 3.7 2 1 1 3 3 3 0 Prefoldin subunit HIP1_clath_bdg PF16515.5 AIF84282.1 - 0.77 10.4 12.2 8.1 7.1 1.7 3.1 1 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 UPF0184 PF03670.13 AIF84282.1 - 0.8 10.1 5.0 0.25 11.7 0.8 2.5 3 1 0 3 3 2 0 Uncharacterised protein family (UPF0184) DUF4795 PF16043.5 AIF84282.1 - 1.1 8.8 14.1 12 5.4 14.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF948 PF06103.11 AIF84282.1 - 1.1 9.6 4.8 7.9 6.8 0.2 3.3 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Med9 PF07544.13 AIF84282.1 - 1.9 8.7 9.2 0.42 10.7 0.7 3.3 1 1 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 FlaC_arch PF05377.11 AIF84282.1 - 1.9 8.9 8.3 5.9 7.4 1.2 3.4 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF3450 PF11932.8 AIF84282.1 - 2.6 7.3 10.4 0.42 9.9 4.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) BST2 PF16716.5 AIF84282.1 - 3.1 8.4 9.7 6.6 7.4 3.6 3.3 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 NPV_P10 PF05531.12 AIF84282.1 - 3.7 8.1 8.8 3.4 8.2 4.7 2.8 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Tho2 PF11262.8 AIF84282.1 - 7.6 5.6 9.6 1.1 8.4 1.6 2.2 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 AAA_5 PF07728.14 AIF84283.1 - 4.5e-10 39.7 0.0 6.9e-06 26.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 AIF84283.1 - 2.7e-09 37.0 0.0 1.2e-06 28.4 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_3 PF07726.11 AIF84283.1 - 7.3e-07 29.1 0.0 5.8e-05 22.9 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 AIF84283.1 - 6.1e-05 22.5 0.0 0.41 10.0 0.0 2.7 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI MCM PF00493.23 AIF84283.1 - 9.2e-05 21.6 0.0 0.0035 16.5 0.0 2.3 2 0 0 2 2 2 1 MCM P-loop domain AAA_PrkA PF08298.11 AIF84283.1 - 0.00019 20.5 0.0 0.0018 17.3 0.0 2.1 1 1 0 1 1 1 1 PrkA AAA domain AAA PF00004.29 AIF84283.1 - 0.022 15.2 0.0 0.65 10.4 0.0 2.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 AIF84283.1 - 0.051 13.7 0.1 1.8 8.7 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain VWA_2 PF13519.6 AIF84284.1 - 4.5e-08 33.7 0.3 4.6e-07 30.4 0.0 2.8 3 1 0 3 3 3 1 von Willebrand factor type A domain KfrA_N PF11740.8 AIF84284.1 - 0.0058 17.3 7.2 0.011 16.3 7.2 1.4 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term DUF5427 PF10310.9 AIF84284.1 - 0.0077 15.2 5.4 0.011 14.7 5.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5427) Presenilin PF01080.17 AIF84284.1 - 2.1 7.0 3.6 3 6.5 3.6 1.1 1 0 0 1 1 1 0 Presenilin Reprolysin_5 PF13688.6 AIF84285.1 - 4e-06 27.1 2.0 4e-06 27.1 2.0 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 AIF84285.1 - 0.00097 19.0 0.3 0.0021 17.9 0.3 1.5 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 AIF84285.1 - 0.0023 18.4 1.3 0.0023 18.4 1.3 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 AIF84285.1 - 0.005 16.5 1.6 0.013 15.2 1.6 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Binary_toxB PF03495.14 AIF84285.1 - 0.026 14.7 0.3 0.084 13.1 0.3 1.9 1 0 0 1 1 1 0 Clostridial binary toxin B/anthrax toxin PA Ca-binding domain Reprolysin PF01421.19 AIF84285.1 - 0.027 14.4 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 Reprolysin (M12B) family zinc metalloprotease DUF4394 PF14339.6 AIF84286.1 - 0.00018 21.0 7.3 0.0042 16.5 0.6 3.2 2 1 1 3 3 3 2 Domain of unknown function (DUF4394) Coatomer_WDAD PF04053.14 AIF84286.1 - 0.0068 15.5 3.3 0.015 14.4 1.2 2.0 2 0 0 2 2 2 1 Coatomer WD associated region DUF5128 PF17170.4 AIF84286.1 - 0.048 12.8 0.1 0.15 11.2 0.0 1.8 1 1 1 2 2 2 0 6-bladed beta-propeller DUF1344 PF07076.11 AIF84286.1 - 0.058 13.3 0.8 4.2 7.4 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) PQQ_3 PF13570.6 AIF84286.1 - 0.1 13.1 3.2 1.6 9.3 0.1 3.7 4 0 0 4 4 4 0 PQQ-like domain Pep3_Vps18 PF05131.14 AIF84286.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Pep3/Vps18/deep orange family PQQ PF01011.21 AIF84286.1 - 5.9 7.0 7.2 2.8 8.0 0.2 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat HAD PF12710.7 AIF84287.1 - 4.6e-13 50.0 0.0 6.4e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AIF84287.1 - 1.1e-11 45.4 0.2 1.8e-10 41.5 0.2 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AIF84287.1 - 0.0004 20.2 0.0 0.00055 19.7 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AIF84287.1 - 0.002 17.7 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Put_Phosphatase PF06888.12 AIF84287.1 - 0.055 12.9 0.0 0.18 11.1 0.0 2.0 1 1 0 1 1 1 0 Putative Phosphatase Ribonuc_L-PSP PF01042.21 AIF84288.1 - 4.2e-27 94.6 0.1 4.9e-27 94.3 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP F420_ligase PF01996.16 AIF84289.1 - 1.7e-60 204.4 1.8 2.1e-60 204.1 1.8 1.0 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase Nucleoporin_C PF03177.14 AIF84289.1 - 0.16 10.7 0.0 0.19 10.4 0.0 1.1 1 0 0 1 1 1 0 Non-repetitive/WGA-negative nucleoporin C-terminal Abhydrolase_1 PF00561.20 AIF84290.1 - 1.4e-28 100.2 0.2 2.1e-25 89.8 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIF84290.1 - 2.1e-18 67.7 0.0 2.8e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AIF84290.1 - 2.8e-17 62.8 0.3 1.8e-16 60.2 0.3 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 AIF84290.1 - 1.2e-05 25.6 0.0 1.3e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain DLH PF01738.18 AIF84290.1 - 7.1e-05 22.5 0.0 0.15 11.6 0.1 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_4 PF08386.10 AIF84290.1 - 0.00029 20.9 0.0 0.00061 19.9 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_2 PF02230.16 AIF84290.1 - 0.00044 20.1 0.0 0.064 13.1 0.0 2.9 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase DUF1057 PF06342.12 AIF84290.1 - 0.00059 19.0 0.0 0.0009 18.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Peptidase_S9 PF00326.21 AIF84290.1 - 0.0031 17.0 0.1 2.7 7.4 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family AXE1 PF05448.12 AIF84290.1 - 0.0059 15.3 1.2 0.52 8.9 0.1 2.7 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) Lipase_3 PF01764.25 AIF84290.1 - 0.014 15.3 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Palm_thioest PF02089.15 AIF84290.1 - 0.021 14.7 0.0 0.087 12.7 0.0 1.9 2 1 0 2 2 2 0 Palmitoyl protein thioesterase Esterase PF00756.20 AIF84290.1 - 0.058 13.0 1.0 0.1 12.2 1.0 1.6 1 1 0 1 1 1 0 Putative esterase Abhydrolase_3 PF07859.13 AIF84290.1 - 0.058 13.2 0.0 0.08 12.8 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 AIF84290.1 - 0.066 12.8 0.0 9.7 5.7 0.0 2.9 2 1 1 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) LIP PF03583.14 AIF84290.1 - 0.1 11.9 0.0 2.8 7.2 0.0 2.1 1 1 0 1 1 1 0 Secretory lipase COesterase PF00135.28 AIF84290.1 - 0.12 11.2 1.7 0.14 11.0 0.5 1.8 2 1 0 2 2 2 0 Carboxylesterase family PGAP1 PF07819.13 AIF84290.1 - 0.14 11.9 0.1 0.59 9.8 0.0 2.0 2 0 0 2 2 2 0 PGAP1-like protein DUF915 PF06028.11 AIF84290.1 - 0.16 11.3 0.1 0.48 9.7 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) DUF726 PF05277.12 AIF84290.1 - 0.23 10.3 0.0 0.37 9.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) TusA PF01206.17 AIF84291.1 - 8.6e-24 83.2 0.0 9.6e-24 83.0 0.0 1.0 1 0 0 1 1 1 1 Sulfurtransferase TusA DUF2249 PF10006.9 AIF84291.1 - 0.017 14.9 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2249) PALP PF00291.25 AIF84292.1 - 7.5e-63 212.7 0.0 9.6e-63 212.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme MlaD PF02470.20 AIF84293.1 - 0.043 14.1 0.1 0.095 13.0 0.1 1.6 1 0 0 1 1 1 0 MlaD protein Pyr_redox_2 PF07992.14 AIF84294.1 - 2.5e-60 204.2 0.8 2.9e-60 204.0 0.8 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AIF84294.1 - 4.3e-28 98.5 3.3 8e-25 87.7 0.2 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AIF84294.1 - 5.5e-20 71.7 3.8 8.2e-20 71.2 0.4 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AIF84294.1 - 1.2e-06 27.9 7.2 0.00026 20.2 0.4 4.2 2 2 4 6 6 6 2 FAD binding domain FAD_oxidored PF12831.7 AIF84294.1 - 1.5e-06 27.9 0.7 0.0025 17.3 0.0 3.0 2 1 1 3 3 3 2 FAD dependent oxidoreductase DAO PF01266.24 AIF84294.1 - 1.6e-06 27.9 8.8 0.0029 17.2 0.0 4.1 2 2 1 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 AIF84294.1 - 3.5e-06 26.4 0.1 0.022 13.9 0.0 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 AIF84294.1 - 5e-06 25.8 5.3 0.048 12.7 0.2 4.5 3 2 2 5 5 5 2 Glucose inhibited division protein A FAD_binding_3 PF01494.19 AIF84294.1 - 9.6e-06 25.1 2.2 0.15 11.3 0.2 3.2 2 1 1 3 3 3 3 FAD binding domain Thi4 PF01946.17 AIF84294.1 - 6e-05 22.4 0.5 0.0019 17.5 0.1 2.6 3 0 0 3 3 3 1 Thi4 family NAD_binding_7 PF13241.6 AIF84294.1 - 0.00015 22.1 0.4 0.027 14.9 0.6 2.5 2 1 0 2 2 2 1 Putative NAD(P)-binding HI0933_like PF03486.14 AIF84294.1 - 0.00021 20.2 1.3 0.04 12.6 0.1 3.2 3 1 0 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.6 AIF84294.1 - 0.00063 19.9 0.2 0.017 15.3 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Phage_SSB PF16773.5 AIF84294.1 - 0.012 15.6 0.1 0.023 14.8 0.1 1.3 1 0 0 1 1 1 0 Lactococcus phage single-stranded DNA binding protein Arteri_nsp7a PF16749.5 AIF84294.1 - 0.012 15.7 0.7 0.37 11.0 0.1 2.4 2 0 0 2 2 2 0 Arterivirus nonstructural protein 7 alpha NAD_binding_9 PF13454.6 AIF84294.1 - 0.015 15.3 0.5 0.86 9.6 0.0 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 AIF84294.1 - 0.046 12.6 0.6 2.9 6.6 0.1 2.9 3 0 0 3 3 3 0 Tryptophan halogenase Lycopene_cycl PF05834.12 AIF84294.1 - 0.098 11.7 0.2 0.83 8.6 0.1 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein TFIIB PF00382.19 AIF84296.1 - 1.5e-28 98.6 3.8 1.2e-14 54.1 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Rrf2 PF02082.20 AIF84296.1 - 0.00041 20.6 0.0 10 6.5 0.0 3.3 3 0 0 3 3 3 2 Transcriptional regulator Cyclin_N PF00134.23 AIF84296.1 - 0.0041 16.9 0.3 0.019 14.7 0.0 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB_C_1 PF18542.1 AIF84296.1 - 0.03 14.3 0.4 5.4 7.1 0.0 2.4 2 0 0 2 2 2 0 Transcription factor IIB C-terminal module 1 DUF2087 PF09860.9 AIF84298.1 - 0.006 16.7 0.0 0.0093 16.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2087) Guanylate_cyc PF00211.20 AIF84299.1 - 1.4e-14 54.1 0.0 1.7e-13 50.6 0.0 2.1 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PGK PF00162.19 AIF84299.1 - 0.0089 15.0 0.1 0.011 14.7 0.1 1.2 1 0 0 1 1 1 1 Phosphoglycerate kinase Terminase_5 PF06056.12 AIF84299.1 - 0.026 14.4 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Dna2 PF08696.11 AIF84299.1 - 0.12 12.1 1.2 0.24 11.2 1.2 1.6 1 0 0 1 1 1 0 DNA replication factor Dna2 AsnC_trans_reg PF01037.21 AIF84300.1 - 8.9e-09 35.2 0.2 1.4e-08 34.6 0.2 1.2 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain PKD PF00801.20 AIF84300.1 - 0.091 12.6 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 PKD domain Radical_SAM PF04055.21 AIF84301.1 - 1.9e-09 38.1 0.3 6.5e-09 36.4 0.2 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 AIF84301.1 - 2.5e-06 27.8 0.1 4.8e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 AIF84301.1 - 0.00011 22.3 0.3 0.00037 20.6 0.1 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain DHquinase_II PF01220.19 AIF84302.1 - 0.088 12.5 0.0 0.095 12.4 0.0 1.0 1 0 0 1 1 1 0 Dehydroquinase class II MMR_HSR1 PF01926.23 AIF84305.1 - 1.2e-06 28.6 0.1 1.6e-06 28.2 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 AIF84305.1 - 0.0063 16.5 0.1 0.018 15.0 0.1 1.8 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 AIF84305.1 - 0.012 15.5 0.1 0.012 15.5 0.1 1.5 2 0 0 2 2 2 0 RsgA GTPase NOG1 PF06858.14 AIF84305.1 - 0.077 12.8 0.2 0.25 11.2 0.2 1.9 1 1 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) AsnC_trans_reg PF01037.21 AIF84306.1 - 5.6e-05 23.0 0.0 6.1e-05 22.9 0.0 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain PHF5 PF03660.14 AIF84307.1 - 0.031 14.5 0.1 0.046 13.9 0.1 1.3 1 0 0 1 1 1 0 PHF5-like protein SNARE_assoc PF09335.11 AIF84309.1 - 2.1e-16 60.5 1.0 3.3e-16 59.8 1.0 1.3 1 0 0 1 1 1 1 SNARE associated Golgi protein DUF3671 PF12420.8 AIF84309.1 - 0.047 13.8 0.5 0.082 13.0 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF4112 PF13430.6 AIF84309.1 - 0.24 11.7 1.7 0.58 10.5 0.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4112) HTH_45 PF14947.6 AIF84310.1 - 2.8e-12 46.5 0.3 3.2e-12 46.3 0.3 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIF84310.1 - 0.0014 18.4 0.1 0.0016 18.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) DUF1495 PF07381.11 AIF84310.1 - 0.038 13.8 0.0 0.078 12.8 0.0 1.6 1 1 1 2 2 2 0 Winged helix DNA-binding domain (DUF1495) Thi4 PF01946.17 AIF84311.1 - 4e-63 212.8 0.0 5e-63 212.5 0.0 1.0 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 AIF84311.1 - 2.5e-12 46.6 0.8 2e-07 30.4 0.3 2.7 2 1 1 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 AIF84311.1 - 5.9e-10 39.1 0.0 9.1e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 AIF84311.1 - 3.4e-08 33.1 0.1 5e-08 32.6 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 AIF84311.1 - 2.4e-07 30.9 0.1 4.8e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 AIF84311.1 - 7.4e-07 28.7 0.1 9.4e-07 28.3 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 AIF84311.1 - 6.1e-06 26.1 2.7 0.00013 21.7 2.1 2.2 1 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 AIF84311.1 - 6.1e-06 25.2 0.1 8.2e-06 24.8 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 AIF84311.1 - 2.6e-05 23.6 1.3 3.7e-05 23.1 1.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 AIF84311.1 - 0.00022 20.4 1.4 0.0022 17.1 1.4 2.0 1 1 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 AIF84311.1 - 0.00023 20.3 0.8 0.00037 19.7 0.8 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 AIF84311.1 - 0.0013 17.7 0.3 0.5 9.2 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase Amino_oxidase PF01593.24 AIF84311.1 - 0.017 14.4 0.1 0.025 13.9 0.1 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase ThiF PF00899.21 AIF84311.1 - 0.037 13.4 0.0 0.095 12.0 0.0 1.6 2 0 0 2 2 2 0 ThiF family Pyr_redox PF00070.27 AIF84311.1 - 0.062 13.9 0.1 0.42 11.2 0.3 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlphaC_C PF17480.2 AIF84311.1 - 0.13 12.3 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 AlphaC C-terminal NitrOD2 PF18550.1 AIF84313.1 - 1.1e-31 109.0 0.0 1.4e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 Nitrososphaera output domain 2 Inos-1-P_synth PF01658.17 AIF84314.1 - 1.5e-15 57.4 0.0 2.6e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase NAD_binding_5 PF07994.12 AIF84314.1 - 1.6e-05 24.5 0.5 0.00043 19.8 0.0 2.3 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase GFO_IDH_MocA PF01408.22 AIF84314.1 - 0.14 13.0 0.3 1.5 9.6 0.2 2.7 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Sacchrp_dh_NADP PF03435.18 AIF84314.1 - 0.15 12.3 0.6 2 8.7 0.0 2.6 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain CoA_binding PF02629.19 AIF84314.1 - 0.17 12.6 1.6 3.5 8.4 0.0 2.8 1 1 1 2 2 2 0 CoA binding domain TPR_1 PF00515.28 AIF84315.1 - 9.4e-30 101.2 4.0 1.7e-13 49.8 1.5 4.9 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 AIF84315.1 - 3e-26 89.4 3.4 1.6e-10 40.3 0.6 5.2 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 AIF84315.1 - 1.1e-22 78.3 7.9 2.4e-10 39.8 0.5 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 AIF84315.1 - 9.9e-20 70.0 2.2 2.6e-07 30.2 1.0 4.5 1 1 3 4 4 4 3 TPR repeat TPR_17 PF13431.6 AIF84315.1 - 2.9e-17 61.7 2.2 1.1e-05 25.5 0.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 AIF84315.1 - 3.5e-15 56.4 0.0 2.9e-07 31.0 0.0 3.6 2 1 3 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 AIF84315.1 - 2.7e-11 43.4 0.0 0.00013 22.0 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 AIF84315.1 - 3.8e-11 43.3 0.1 3.4e-06 27.5 0.0 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 AIF84315.1 - 8.4e-11 41.8 0.0 0.00067 20.3 0.0 4.7 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 AIF84315.1 - 1.6e-09 37.9 0.4 5.1e-05 23.5 0.1 4.0 1 1 1 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AIF84315.1 - 2.1e-09 37.5 9.6 7.9e-06 26.0 0.8 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 AIF84315.1 - 1.6e-07 30.9 0.0 0.014 15.4 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AIF84315.1 - 3.1e-07 30.3 0.2 0.0049 16.9 0.1 3.3 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 AIF84315.1 - 1.3e-05 25.6 1.0 0.034 14.8 0.0 4.7 6 0 0 6 6 4 1 Tetratricopeptide repeat NARP1 PF12569.8 AIF84315.1 - 0.00074 18.5 0.4 0.51 9.2 0.1 2.2 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 AIF84315.1 - 0.028 14.7 0.0 0.13 12.6 0.0 2.2 2 1 0 2 2 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 AIF84315.1 - 0.038 13.9 0.1 0.88 9.5 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2250 PF10007.9 AIF84315.1 - 0.11 12.6 0.2 0.36 11.0 0.2 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) Alkyl_sulf_dimr PF14863.6 AIF84315.1 - 0.17 12.4 1.0 27 5.2 0.1 2.6 2 1 0 2 2 2 0 Alkyl sulfatase dimerisation Cytochrom_B562 PF07361.11 AIF84315.1 - 0.7 10.6 3.6 0.7 10.6 0.1 2.7 3 0 0 3 3 3 0 Cytochrome b562 AA_kinase PF00696.28 AIF84317.1 - 8.1e-33 114.0 1.3 9.4e-33 113.8 1.3 1.0 1 0 0 1 1 1 1 Amino acid kinase family FMN_dh PF01070.18 AIF84318.1 - 3.2e-24 85.6 0.2 4.9e-23 81.7 0.2 2.0 1 1 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 AIF84318.1 - 9.9e-05 21.9 1.8 0.00025 20.5 1.7 1.8 1 1 0 1 1 1 1 Nitronate monooxygenase Glu_synthase PF01645.17 AIF84318.1 - 0.0002 20.6 3.0 0.00044 19.5 3.0 1.5 1 1 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 AIF84318.1 - 0.023 13.7 6.8 0.027 13.5 0.2 2.8 2 2 1 4 4 4 0 IMP dehydrogenase / GMP reductase domain polyprenyl_synt PF00348.17 AIF84319.1 - 3.9e-67 226.0 0.0 4.7e-67 225.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase tRNA-synt_1c PF00749.21 AIF84320.1 - 1e-78 264.4 0.0 1.3e-78 264.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 AIF84320.1 - 1.5e-32 112.9 0.0 2.5e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain FAA_hydrolase PF01557.18 AIF84321.1 - 3.2e-68 229.7 0.0 4.5e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family SIMPL PF04402.14 AIF84322.1 - 7.8e-32 111.4 9.5 2.2e-21 77.2 0.1 2.7 1 1 1 2 2 2 2 Protein of unknown function (DUF541) Flg_hook PF02120.16 AIF84322.1 - 0.0064 16.4 0.2 1.9 8.4 0.1 3.2 3 1 0 3 3 3 1 Flagellar hook-length control protein FliK THEG4 PF15834.5 AIF84322.1 - 0.14 12.2 0.1 14 5.7 0.0 2.4 2 1 0 2 2 2 0 Testis highly expressed protein 4 PepSY_TM PF03929.16 AIF84322.1 - 0.53 9.9 2.8 0.61 9.7 2.2 1.5 1 1 0 1 1 1 0 PepSY-associated TM region FMN_red PF03358.15 AIF84323.1 - 6.6e-28 97.4 0.0 8.1e-28 97.1 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 AIF84323.1 - 1.7e-11 44.2 0.0 2.3e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Usp PF00582.26 AIF84323.1 - 0.00062 20.3 0.0 0.00082 19.9 0.0 1.2 1 0 0 1 1 1 1 Universal stress protein family Flavodoxin_5 PF12724.7 AIF84323.1 - 0.0061 16.8 0.0 0.025 14.8 0.0 1.9 2 0 0 2 2 2 1 Flavodoxin domain Nsp3_PL2pro PF12124.8 AIF84323.1 - 0.055 13.3 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 Coronavirus polyprotein cleavage domain HTH_20 PF12840.7 AIF84324.1 - 4.5e-15 55.4 0.2 7.6e-15 54.7 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 AIF84324.1 - 1.9e-14 53.2 0.1 3.9e-14 52.2 0.0 1.6 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 AIF84324.1 - 0.00047 20.0 0.3 0.00076 19.3 0.3 1.4 1 0 0 1 1 1 1 MarR family HxlR PF01638.17 AIF84324.1 - 0.004 17.0 0.0 0.0089 15.9 0.0 1.6 1 1 0 1 1 1 1 HxlR-like helix-turn-helix HTH_Crp_2 PF13545.6 AIF84324.1 - 0.012 15.5 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain TrmB PF01978.19 AIF84324.1 - 0.02 14.8 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 AIF84324.1 - 0.036 13.6 0.0 0.11 12.1 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding AHSA1 PF08327.11 AIF84325.1 - 5e-18 65.5 0.0 8.5e-18 64.8 0.0 1.4 1 1 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 AIF84325.1 - 1.8e-05 25.0 0.1 2.6e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIF84325.1 - 0.014 15.6 0.6 0.16 12.2 0.5 2.5 1 1 1 2 2 2 0 Polyketide cyclase / dehydrase and lipid transport TetR_C_22 PF17928.1 AIF84327.1 - 0.036 14.4 0.1 0.05 13.9 0.1 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF1192 PF06698.11 AIF84327.1 - 0.061 13.4 0.8 0.46 10.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) SlyX PF04102.12 AIF84327.1 - 0.53 11.0 3.4 0.58 10.8 0.2 2.2 1 1 1 2 2 2 0 SlyX NAD_binding_1 PF00175.21 AIF84328.1 - 4.3e-11 43.4 0.0 7.5e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AIF84328.1 - 3.9e-09 36.8 0.0 5.8e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AIF84328.1 - 0.063 13.4 0.1 0.19 11.8 0.0 1.7 1 1 0 2 2 2 0 Ferric reductase NAD binding domain Radical_SAM PF04055.21 AIF84330.1 - 1.6e-12 48.2 0.0 2.9e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily B12-binding PF02310.19 AIF84330.1 - 0.15 12.1 0.0 0.73 9.9 0.0 2.1 2 0 0 2 2 2 0 B12 binding domain NUDIX PF00293.28 AIF84331.1 - 5.9e-18 65.2 0.0 7.3e-18 64.9 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 AIF84331.1 - 0.017 14.7 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 Nucleotide hydrolase NUDIX_4 PF14815.6 AIF84331.1 - 0.12 12.4 0.1 0.29 11.1 0.1 1.6 1 1 0 1 1 1 0 NUDIX domain DUF98 PF01947.16 AIF84332.1 - 0.0072 16.3 0.5 0.31 11.0 0.5 2.7 1 1 0 1 1 1 1 p-hydroxybenzoic acid synthase UbiA PF01040.18 AIF84333.1 - 0.00064 19.1 18.6 0.0027 17.1 18.1 1.9 1 1 0 1 1 1 1 UbiA prenyltransferase family Ubie_methyltran PF01209.18 AIF84334.1 - 3.6e-19 69.0 0.0 4.5e-19 68.7 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 AIF84334.1 - 9.6e-19 67.8 0.1 1.9e-18 66.9 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF84334.1 - 6.4e-18 65.3 0.1 1.5e-17 64.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF84334.1 - 4.7e-12 46.1 0.0 6.4e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF84334.1 - 4.7e-09 36.2 0.0 7.7e-09 35.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF84334.1 - 1.8e-07 31.8 0.0 4.2e-07 30.6 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 AIF84334.1 - 9.7e-06 25.2 0.0 1.4e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 AIF84334.1 - 1.6e-05 24.5 0.0 2.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.6 AIF84334.1 - 0.0029 18.6 0.0 0.0065 17.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 AIF84334.1 - 0.0032 17.1 0.0 0.0048 16.5 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.20 AIF84334.1 - 0.013 14.8 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 AIF84334.1 - 0.11 12.5 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Putative_PNPOx PF01243.20 AIF84335.1 - 1.7e-12 47.4 0.0 2.4e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AIF84335.1 - 8.2e-06 25.9 0.0 1.2e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF2748 PF10871.8 AIF84337.1 - 0.035 12.7 0.0 0.037 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2748) Peptidase_C65 PF10275.9 AIF84337.1 - 0.12 11.8 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase C65 Otubain DUF1090 PF06476.12 AIF84338.1 - 0.00027 21.0 11.8 0.00027 21.0 11.8 3.8 1 1 3 4 4 3 1 Protein of unknown function (DUF1090) MscS_porin PF12795.7 AIF84338.1 - 0.005 16.4 2.3 0.005 16.4 2.3 3.4 1 1 1 3 3 3 1 Mechanosensitive ion channel porin domain Sec34 PF04136.15 AIF84338.1 - 0.065 13.1 17.4 0.13 12.1 4.6 3.8 1 1 3 4 4 4 0 Sec34-like family NPV_P10 PF05531.12 AIF84338.1 - 0.16 12.5 10.5 21 5.7 3.5 4.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 AIF84338.1 - 0.52 10.3 22.4 0.45 10.5 5.6 3.2 1 1 2 3 3 3 0 Laminin Domain II XhlA PF10779.9 AIF84338.1 - 0.76 10.0 0.1 0.76 10.0 0.1 5.1 3 2 2 6 6 6 0 Haemolysin XhlA Allexi_40kDa PF05549.11 AIF84338.1 - 1.1 8.7 22.2 0.53 9.8 3.7 3.1 1 1 2 3 3 3 0 Allexivirus 40kDa protein DUF1664 PF07889.12 AIF84338.1 - 2.5 8.1 25.0 0.11 12.6 1.7 3.7 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 AIF84338.1 - 2.7 7.3 33.9 3.8 6.8 10.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) COG2 PF06148.11 AIF84338.1 - 4 7.5 30.3 0.33 11.0 2.7 4.2 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 UPF0184 PF03670.13 AIF84338.1 - 4.7 7.7 9.1 0.52 10.7 0.9 3.2 2 2 1 3 3 3 0 Uncharacterised protein family (UPF0184) Fmp27_WPPW PF10359.9 AIF84338.1 - 5.6 5.7 35.8 0.26 10.1 14.7 2.4 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain FlaC_arch PF05377.11 AIF84338.1 - 8 6.9 21.8 5.1 7.6 0.2 5.2 3 2 1 5 5 5 0 Flagella accessory protein C (FlaC) Tweety PF04906.13 AIF84338.1 - 8.6 4.9 17.2 0.45 9.1 2.6 2.8 1 1 1 3 3 3 0 Tweety Molydop_binding PF01568.21 AIF84339.1 - 0.022 14.8 0.0 0.075 13.1 0.0 1.8 1 1 0 1 1 1 0 Molydopterin dinucleotide binding domain DUF1512 PF07431.12 AIF84341.1 - 1.8e-131 438.4 14.5 2.3e-131 438.1 14.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1512) ATP-synt_8 PF00895.20 AIF84341.1 - 0.49 10.9 1.6 0.5 10.9 0.2 1.7 2 0 0 2 2 2 0 ATP synthase protein 8 Nudix_N_2 PF14803.6 AIF84342.1 - 0.0025 17.7 0.5 0.0085 16.0 0.5 1.7 1 1 1 2 2 2 1 Nudix N-terminal OrfB_Zn_ribbon PF07282.11 AIF84342.1 - 0.0059 16.5 5.5 0.029 14.3 5.5 1.8 1 1 1 2 2 2 1 Putative transposase DNA-binding domain DZR PF12773.7 AIF84342.1 - 0.0086 16.1 1.0 0.012 15.6 1.0 1.3 1 1 0 1 1 1 1 Double zinc ribbon Zn-ribbon_8 PF09723.10 AIF84342.1 - 0.015 15.4 1.3 3.8 7.7 0.2 2.2 2 0 0 2 2 2 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 AIF84342.1 - 0.017 14.7 2.7 1.8 8.1 0.1 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding ADK_lid PF05191.14 AIF84342.1 - 0.044 13.8 1.3 5.7 7.0 0.1 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid Prok-RING_1 PF14446.6 AIF84342.1 - 0.059 13.3 1.3 0.13 12.2 1.3 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 A2L_zn_ribbon PF08792.10 AIF84342.1 - 0.078 12.7 2.5 2.7 7.8 0.1 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain YdjO PF14169.6 AIF84342.1 - 0.097 12.4 2.6 6.3 6.6 0.1 2.2 1 1 1 2 2 2 0 Cold-inducible protein YdjO C1_1 PF00130.22 AIF84342.1 - 0.1 12.5 1.5 0.52 10.2 1.6 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HypA PF01155.19 AIF84342.1 - 0.11 12.5 0.4 0.12 12.4 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_3 PF13878.6 AIF84342.1 - 0.12 12.2 1.8 8 6.4 0.2 2.2 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-dskA_traR PF01258.17 AIF84342.1 - 1.9 8.5 5.8 3 7.9 0.9 2.2 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger Peptidase_M24 PF00557.24 AIF84343.1 - 2e-35 122.4 0.2 2e-35 122.4 0.2 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Plexin_cytopl PF08337.12 AIF84343.1 - 0.09 11.4 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Plexin cytoplasmic RasGAP domain Peptidase_M10 PF00413.24 AIF84344.1 - 2.8e-05 24.0 0.1 3.8e-05 23.6 0.1 1.3 1 1 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.9 AIF84344.1 - 0.0071 15.3 1.7 0.018 14.0 1.7 1.7 1 1 0 1 1 1 1 Peptidase M66 Metallopep PF12044.8 AIF84344.1 - 0.011 14.4 0.3 0.016 13.9 0.3 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_3 PF13582.6 AIF84344.1 - 0.044 14.3 0.0 0.073 13.6 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like BSP PF04450.12 AIF84344.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase of plants and bacteria P-II PF00543.22 AIF84345.1 - 8.1e-29 100.2 0.0 9.2e-29 100.1 0.0 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II T2SSE PF00437.20 AIF84346.1 - 4.3e-11 42.4 0.0 2e-10 40.2 0.0 2.2 2 1 0 2 2 2 1 Type II/IV secretion system protein KH_1 PF00013.29 AIF84346.1 - 1.7e-09 37.4 0.1 6.7e-09 35.4 0.1 2.1 1 0 0 1 1 1 1 KH domain AAA_16 PF13191.6 AIF84346.1 - 2.8e-05 24.6 0.1 7.9e-05 23.1 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain AAA_25 PF13481.6 AIF84346.1 - 5.6e-05 22.8 0.0 0.00012 21.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain PIN_4 PF13638.6 AIF84346.1 - 7.1e-05 23.1 0.3 0.00022 21.5 0.3 1.9 1 1 0 1 1 1 1 PIN domain KH_2 PF07650.17 AIF84346.1 - 0.00018 21.2 0.1 0.00093 19.0 0.1 2.3 1 0 0 1 1 1 1 KH domain AAA_18 PF13238.6 AIF84346.1 - 0.00023 21.7 0.0 0.0006 20.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 AIF84346.1 - 0.00023 20.2 0.0 0.00046 19.3 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 AIF84346.1 - 0.00045 20.0 0.0 0.00091 19.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein ABC_tran PF00005.27 AIF84346.1 - 0.001 19.6 0.0 0.0028 18.2 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 AIF84346.1 - 0.0015 18.3 0.1 0.0088 15.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AIF84346.1 - 0.0016 18.7 0.1 0.012 15.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 AIF84346.1 - 0.0023 17.9 0.0 0.0057 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 AIF84346.1 - 0.003 17.6 0.0 0.026 14.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 AIF84346.1 - 0.0039 17.1 0.1 0.02 14.8 0.0 2.3 2 0 0 2 2 2 1 NTPase KH_4 PF13083.6 AIF84346.1 - 0.0081 16.0 1.1 0.042 13.7 0.0 2.8 3 0 0 3 3 2 1 KH domain AAA_33 PF13671.6 AIF84346.1 - 0.01 16.0 0.1 0.037 14.2 0.0 2.0 2 0 0 2 2 1 1 AAA domain ATP_bind_1 PF03029.17 AIF84346.1 - 0.012 15.4 0.1 0.022 14.5 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein PIN PF01850.21 AIF84346.1 - 0.012 16.1 1.6 0.028 14.9 1.6 1.6 1 0 0 1 1 1 0 PIN domain AAA_29 PF13555.6 AIF84346.1 - 0.015 15.1 0.0 0.046 13.5 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain DnaB_C PF03796.15 AIF84346.1 - 0.016 14.6 0.2 0.081 12.2 0.0 2.2 2 1 0 2 2 2 0 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 AIF84346.1 - 0.02 14.2 0.1 0.049 12.9 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 AIF84346.1 - 0.022 15.0 0.0 0.046 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 AIF84346.1 - 0.023 15.1 0.1 0.089 13.2 0.0 2.1 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 AIF84346.1 - 0.026 14.5 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 AIF84346.1 - 0.028 13.6 0.0 0.062 12.5 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Mg_chelatase PF01078.21 AIF84346.1 - 0.033 13.5 0.1 0.098 12.0 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PIN_5 PF08745.11 AIF84346.1 - 0.035 13.5 0.0 0.089 12.2 0.0 1.7 1 0 0 1 1 1 0 PINc domain ribonuclease KTI12 PF08433.10 AIF84346.1 - 0.05 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 AIF84346.1 - 0.056 13.2 0.1 0.14 11.9 0.0 1.7 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 AIF84346.1 - 0.06 13.7 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase KH_5 PF13184.6 AIF84346.1 - 0.066 13.3 0.2 0.17 12.0 0.2 1.7 1 0 0 1 1 1 0 NusA-like KH domain AAA_17 PF13207.6 AIF84346.1 - 0.093 13.2 0.2 0.29 11.5 0.2 1.9 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 AIF84346.1 - 0.1 12.3 0.0 0.46 10.1 0.0 1.9 1 1 0 2 2 2 0 Thymidylate kinase RsgA_GTPase PF03193.16 AIF84346.1 - 0.12 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 AIF84346.1 - 0.13 12.4 0.0 0.29 11.2 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase PPV_E1_C PF00519.17 AIF84346.1 - 0.13 11.1 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase DEPP PF15343.6 AIF84346.1 - 0.14 12.3 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Decidual protein induced by progesterone family Fe_dep_repress PF01325.19 AIF84347.1 - 7.6e-22 77.3 1.8 1.3e-21 76.5 0.8 1.9 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain Fe_dep_repr_C PF02742.15 AIF84347.1 - 1.2e-14 54.1 0.5 2.9e-14 52.9 0.5 1.6 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain MarR_2 PF12802.7 AIF84347.1 - 6.8e-06 25.9 0.0 1.6e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 MarR family TrmB PF01978.19 AIF84347.1 - 7.3e-05 22.6 0.1 0.00014 21.7 0.1 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 AIF84347.1 - 0.00026 20.9 0.0 0.001 19.0 0.0 1.9 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 AIF84347.1 - 0.00026 20.5 0.0 0.00049 19.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding LexA_DNA_bind PF01726.16 AIF84347.1 - 0.00032 20.4 0.0 0.00082 19.1 0.0 1.7 2 0 0 2 2 2 1 LexA DNA binding domain MarR PF01047.22 AIF84347.1 - 0.00049 20.0 0.1 0.0014 18.6 0.0 1.8 2 0 0 2 2 1 1 MarR family HTH_11 PF08279.12 AIF84347.1 - 0.00074 19.4 0.0 0.0017 18.2 0.0 1.7 1 0 0 1 1 1 1 HTH domain Rrf2 PF02082.20 AIF84347.1 - 0.0033 17.7 0.1 0.0054 17.1 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator FeoC PF09012.10 AIF84347.1 - 0.0044 17.1 0.0 0.011 15.8 0.0 1.7 2 0 0 2 2 2 1 FeoC like transcriptional regulator HTH_DeoR PF08220.12 AIF84347.1 - 0.0055 16.4 0.1 0.031 14.0 0.0 2.2 2 1 1 3 3 3 1 DeoR-like helix-turn-helix domain HTH_37 PF13744.6 AIF84347.1 - 0.012 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Ribosomal_S8 PF00410.19 AIF84347.1 - 0.017 15.1 0.2 0.029 14.3 0.2 1.4 1 1 0 1 1 1 0 Ribosomal protein S8 TFIIE_alpha PF02002.17 AIF84347.1 - 0.021 14.7 0.1 0.039 13.8 0.0 1.6 2 0 0 2 2 2 0 TFIIE alpha subunit PAX PF00292.18 AIF84347.1 - 0.05 13.5 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 'Paired box' domain HTH_27 PF13463.6 AIF84347.1 - 0.055 14.0 0.1 0.34 11.5 0.0 2.3 2 1 1 3 3 3 0 Winged helix DNA-binding domain HTH_5 PF01022.20 AIF84347.1 - 0.075 12.9 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_6 PF01418.17 AIF84347.1 - 0.088 12.8 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family TALPID3 PF15324.6 AIF84347.1 - 0.1 10.2 0.1 0.12 10.0 0.1 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Rhodanese PF00581.20 AIF84348.1 - 7.6e-38 129.3 0.2 1.5e-19 70.5 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain SIS PF01380.22 AIF84349.1 - 2.1e-12 47.1 1.4 1.3e-06 28.3 0.6 3.0 2 1 0 2 2 2 2 SIS domain SIS_2 PF13580.6 AIF84349.1 - 0.018 15.1 0.4 0.018 15.1 0.4 2.0 2 0 0 2 2 2 0 SIS domain AsnC_trans_reg PF01037.21 AIF84350.1 - 5.2e-12 45.6 0.1 5.7e-12 45.4 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIF84350.1 - 0.067 13.3 0.1 0.092 12.8 0.1 1.2 1 0 0 1 1 1 0 NapD protein META PF03724.16 AIF84351.1 - 1.4e-09 37.9 0.0 1.7e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 META domain AcetylCoA_hyd_C PF13336.6 AIF84351.1 - 0.024 14.6 0.1 0.031 14.2 0.1 1.2 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain Methyltransf_25 PF13649.6 AIF84352.1 - 1.5e-17 64.1 0.0 3.9e-17 62.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF84352.1 - 2.2e-16 60.0 0.0 3.3e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF84352.1 - 8e-16 58.5 0.0 1.6e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF84352.1 - 7.3e-10 39.5 0.0 1.7e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF84352.1 - 9.5e-09 35.3 0.0 2.5e-07 30.7 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF84352.1 - 1.4e-07 31.1 0.0 2.4e-07 30.3 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 AIF84352.1 - 0.0014 18.2 0.0 0.0042 16.6 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase DREV PF05219.12 AIF84352.1 - 0.013 14.6 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_9 PF08003.11 AIF84352.1 - 0.049 12.5 0.0 0.068 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Trm112p PF03966.16 AIF84352.1 - 0.05 14.2 0.1 0.1 13.2 0.1 1.6 1 0 0 1 1 1 0 Trm112p-like protein MTS PF05175.14 AIF84352.1 - 0.076 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 AIF84352.1 - 0.17 11.6 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Urocanase PF01175.18 AIF84353.1 - 0.15 11.7 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Urocanase Rossmann-like domain FixG_C PF11614.8 AIF84354.1 - 0.14 12.4 0.2 5.8 7.1 0.0 2.4 1 1 1 2 2 2 0 IG-like fold at C-terminal of FixG, putative oxidoreductase GerE PF00196.19 AIF84355.1 - 0.00099 18.6 0.1 0.0024 17.4 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family AsnC_trans_reg PF01037.21 AIF84355.1 - 0.004 17.1 0.0 0.0069 16.3 0.0 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 AIF84355.1 - 0.005 16.4 1.8 0.017 14.7 1.8 2.0 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF84355.1 - 0.0052 16.6 0.9 0.021 14.6 0.9 2.0 1 1 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_23 PF13384.6 AIF84355.1 - 0.0059 16.4 0.1 0.016 15.0 0.0 1.7 2 0 0 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 AIF84355.1 - 0.012 15.3 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 DELLA PF12041.8 AIF84355.1 - 0.04 13.8 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal RnfC_N PF13375.6 AIF84355.1 - 0.12 12.4 0.8 0.35 10.8 0.9 1.9 1 1 0 1 1 1 0 RnfC Barrel sandwich hybrid domain HTH_AsnC-type PF13404.6 AIF84356.1 - 0.014 15.2 0.1 0.025 14.4 0.1 1.4 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain ADK PF00406.22 AIF84356.1 - 0.029 14.5 0.1 0.039 14.1 0.1 1.1 1 0 0 1 1 1 0 Adenylate kinase ACT_4 PF13291.6 AIF84356.1 - 0.069 13.7 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 ACT domain Alba PF01918.21 AIF84357.1 - 7.3e-11 41.7 0.1 9.5e-11 41.4 0.1 1.2 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 AIF84357.1 - 0.078 12.9 0.9 1 9.3 0.1 2.2 1 1 1 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P Aminotran_4 PF01063.19 AIF84359.1 - 5e-49 167.2 0.0 5.8e-49 166.9 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV Glyco_hydro_36N PF16875.5 AIF84359.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 36 N-terminal domain GFO_IDH_MocA PF01408.22 AIF84360.1 - 1.2e-25 90.6 0.0 2.4e-25 89.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold IlvN PF07991.12 AIF84360.1 - 6e-05 22.7 0.2 0.00037 20.1 0.0 2.3 2 1 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain GFO_IDH_MocA_C PF02894.17 AIF84360.1 - 0.00014 21.9 0.0 0.00037 20.5 0.0 1.8 2 1 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_Gly3P_dh_N PF01210.23 AIF84360.1 - 0.0059 16.6 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 AIF84360.1 - 0.0072 15.7 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 AIF84360.1 - 0.0088 16.2 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase CoA_binding PF02629.19 AIF84360.1 - 0.054 14.2 0.0 0.14 12.9 0.0 1.7 1 0 0 1 1 1 0 CoA binding domain Shikimate_DH PF01488.20 AIF84360.1 - 0.071 13.2 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 AIF84360.1 - 0.11 12.8 0.4 0.36 11.1 0.4 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Trm112p PF03966.16 AIF84361.1 - 9.4e-08 32.5 0.3 2.6e-07 31.1 0.3 1.7 1 1 0 1 1 1 1 Trm112p-like protein Methyltransf_14 PF08484.11 AIF84361.1 - 0.18 11.6 0.0 0.22 11.3 0.0 1.1 1 0 0 1 1 1 0 C-methyltransferase C-terminal domain Hexapep PF00132.24 AIF84362.1 - 6e-26 89.2 32.2 6.1e-09 35.3 0.5 4.1 2 1 2 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 AIF84362.1 - 7.6e-19 67.2 13.0 3e-10 39.7 2.6 4.2 3 1 1 4 4 4 4 Hexapeptide repeat of succinyl-transferase 2-Hacid_dh_C PF02826.19 AIF84363.1 - 4.8e-65 218.3 0.1 6.8e-65 217.7 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 AIF84363.1 - 4.8e-26 91.0 0.0 1e-25 90.0 0.0 1.8 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 AIF84363.1 - 0.00032 20.9 0.1 0.00082 19.6 0.1 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 AIF84363.1 - 0.0024 17.5 0.4 0.015 14.8 0.0 2.3 2 1 1 3 3 3 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 AIF84363.1 - 0.006 17.1 0.0 0.019 15.5 0.0 2.0 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Vip3A_N PF12495.8 AIF84364.1 - 0.00021 21.2 0.1 0.00021 21.2 0.1 1.1 1 0 0 1 1 1 1 Vegetative insecticide protein 3A N terminal DASH_Dad1 PF08649.10 AIF84364.1 - 0.021 15.0 0.3 0.033 14.4 0.3 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad1 TBCA PF02970.16 AIF84364.1 - 0.026 14.8 0.2 0.027 14.8 0.2 1.1 1 0 0 1 1 1 0 Tubulin binding cofactor A DUF354 PF04007.12 AIF84365.1 - 2e-50 171.8 0.0 2.4e-50 171.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF354) Glyco_tran_28_C PF04101.16 AIF84365.1 - 0.012 15.6 0.1 0.021 14.8 0.1 1.4 1 1 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain LpxB PF02684.15 AIF84365.1 - 0.014 14.3 0.0 0.018 13.9 0.0 1.2 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase Epimerase_2 PF02350.19 AIF84365.1 - 0.014 14.3 0.0 0.022 13.6 0.0 1.3 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Glyco_trans_4_4 PF13579.6 AIF84365.1 - 0.021 15.3 0.4 0.098 13.1 0.1 2.1 3 0 0 3 3 3 0 Glycosyl transferase 4-like domain CutA1 PF03091.15 AIF84367.1 - 1.9e-29 101.4 0.1 2.2e-29 101.2 0.1 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Ribosomal_L11 PF00298.19 AIF84367.1 - 0.067 13.7 0.0 0.22 12.0 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L11, RNA binding domain eRF1_1 PF03463.15 AIF84368.1 - 7.1e-21 74.5 0.1 1.1e-20 73.9 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 AIF84368.1 - 2.8e-11 43.9 0.5 1.2e-10 41.9 0.3 2.2 3 0 0 3 3 3 1 eRF1 domain 3 Fe_dep_repr_C PF02742.15 AIF84370.1 - 2.7e-19 69.0 0.5 4.4e-19 68.3 0.5 1.4 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain Fe_dep_repress PF01325.19 AIF84370.1 - 2e-14 53.5 0.5 3.7e-14 52.7 0.5 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_5 PF01022.20 AIF84370.1 - 2.8e-05 23.9 0.0 6.2e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family Rrf2 PF02082.20 AIF84370.1 - 0.0002 21.7 0.1 0.00033 21.0 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator MarR_2 PF12802.7 AIF84370.1 - 0.0003 20.6 0.0 0.00048 20.0 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_1 PF00126.27 AIF84370.1 - 0.00045 20.1 0.0 0.00088 19.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR PF01047.22 AIF84370.1 - 0.0011 18.9 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIF84370.1 - 0.0023 17.8 0.1 0.0038 17.1 0.1 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 AIF84370.1 - 0.0024 18.3 0.0 0.0038 17.7 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_Crp_2 PF13545.6 AIF84370.1 - 0.0032 17.4 0.0 0.0059 16.6 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_45 PF14947.6 AIF84370.1 - 0.0041 17.1 0.1 0.0065 16.4 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_37 PF13744.6 AIF84370.1 - 0.0043 17.0 0.0 0.0084 16.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_IclR PF09339.10 AIF84370.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain AAA_assoc_C PF09821.9 AIF84370.1 - 0.014 15.9 0.1 0.027 15.0 0.1 1.4 1 1 0 1 1 1 0 C-terminal AAA-associated domain IF2_N PF04760.15 AIF84370.1 - 0.044 13.6 0.4 0.31 10.9 0.1 2.1 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region HrcA_DNA-bdg PF03444.15 AIF84370.1 - 0.053 13.2 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding TFIIE_beta PF02186.15 AIF84370.1 - 0.071 13.4 0.5 0.33 11.3 0.1 2.1 1 1 1 2 2 2 0 TFIIE beta subunit core domain HTH_6 PF01418.17 AIF84370.1 - 0.075 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family NLPC_P60 PF00877.19 AIF84370.1 - 0.076 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 NlpC/P60 family HTH_11 PF08279.12 AIF84370.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 HTH domain HTH_20 PF12840.7 AIF84370.1 - 0.15 12.2 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain TrmB PF01978.19 AIF84371.1 - 1.8e-22 79.0 0.0 4.4e-22 77.7 0.0 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 AIF84371.1 - 1.9e-08 33.8 0.0 2.4e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_IclR PF09339.10 AIF84371.1 - 2e-05 24.3 0.0 4.9e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 IclR helix-turn-helix domain MarR PF01047.22 AIF84371.1 - 0.00018 21.4 0.0 0.00073 19.4 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.6 AIF84371.1 - 0.0016 17.9 0.0 0.0034 16.9 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_27 PF13463.6 AIF84371.1 - 0.0084 16.6 0.0 0.045 14.3 0.0 2.2 3 0 0 3 3 2 1 Winged helix DNA-binding domain Penicillinase_R PF03965.16 AIF84371.1 - 0.0086 16.4 0.0 0.028 14.8 0.0 1.9 2 1 0 2 2 2 1 Penicillinase repressor MarR_2 PF12802.7 AIF84371.1 - 0.015 15.2 0.0 0.05 13.5 0.0 1.9 2 0 0 2 2 2 0 MarR family HTH_9 PF08221.11 AIF84371.1 - 0.03 14.4 0.0 0.086 13.0 0.0 1.7 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain PadR PF03551.14 AIF84371.1 - 0.037 14.0 0.0 0.087 12.8 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family Rrf2 PF02082.20 AIF84371.1 - 0.041 14.2 0.0 0.15 12.4 0.0 1.8 2 0 0 2 2 2 0 Transcriptional regulator Nuf2 PF03800.14 AIF84371.1 - 0.06 13.5 0.0 0.14 12.3 0.0 1.6 2 0 0 2 2 2 0 Nuf2 family HTH_36 PF13730.6 AIF84371.1 - 0.07 13.1 0.0 0.17 11.9 0.0 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain Radical_SAM PF04055.21 AIF84372.1 - 1e-17 65.0 0.1 1e-17 65.0 0.1 2.6 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 AIF84372.1 - 1.4e-07 31.9 0.0 3.5e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 AIF84372.1 - 2.2e-07 31.0 0.0 2.2e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain HTH_45 PF14947.6 AIF84373.1 - 0.00075 19.4 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix TrmB PF01978.19 AIF84373.1 - 0.0054 16.6 0.0 0.0099 15.7 0.0 1.5 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.20 AIF84373.1 - 0.0088 15.9 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 AIF84373.1 - 0.044 13.7 0.1 0.09 12.7 0.1 1.4 1 0 0 1 1 1 0 MarR family HTH_20 PF12840.7 AIF84373.1 - 0.045 13.8 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4364 PF14277.6 AIF84373.1 - 0.25 11.1 0.0 0.36 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) HTH_45 PF14947.6 AIF84374.1 - 3.3e-17 62.2 0.0 3.9e-17 62.0 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix bPH_5 PF10882.8 AIF84376.1 - 2.7e-06 27.4 0.0 3.4e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial PH domain Peptidase_M32 PF02074.15 AIF84377.1 - 3e-06 26.3 0.9 0.00076 18.4 0.0 2.5 3 0 0 3 3 3 2 Carboxypeptidase Taq (M32) metallopeptidase Peptidase_M3 PF01432.20 AIF84377.1 - 0.0001 21.7 1.1 0.0011 18.3 1.1 2.3 1 1 0 1 1 1 1 Peptidase family M3 MCM_N PF14551.6 AIF84377.1 - 0.033 14.8 0.1 0.093 13.3 0.1 1.7 1 0 0 1 1 1 0 MCM N-terminal domain Proteasome PF00227.26 AIF84378.1 - 5.9e-55 185.7 1.0 6.8e-55 185.5 1.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Aconitase PF00330.20 AIF84379.1 - 2.6e-156 521.2 0.0 3e-156 521.0 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) DUF521 PF04412.13 AIF84379.1 - 0.011 14.5 0.0 0.034 12.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF521) Aconitase_C PF00694.19 AIF84380.1 - 3.6e-36 124.4 0.0 4.7e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.13 AIF84380.1 - 0.00076 19.2 0.0 0.041 13.5 0.0 2.1 1 1 0 1 1 1 1 Aconitate hydratase 2 N-terminus GATase_7 PF13537.6 AIF84381.1 - 0.11 12.4 0.0 0.41 10.6 0.0 2.0 2 0 0 2 2 2 0 Glutamine amidotransferase domain DUF4156 PF13698.6 AIF84381.1 - 0.2 12.0 0.0 3.4 8.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4156) NT5C PF06941.12 AIF84383.1 - 3.5e-16 59.6 0.3 3.9e-16 59.4 0.3 1.0 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Response_reg PF00072.24 AIF84386.1 - 5.6e-24 84.5 0.4 6.3e-24 84.3 0.4 1.0 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 AIF84387.1 - 2.2e-24 86.1 0.1 7.5e-24 84.4 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIF84387.1 - 1.1e-10 41.4 0.7 3.3e-10 39.9 0.7 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 AIF84387.1 - 0.023 14.6 0.5 0.38 10.7 0.0 3.2 3 0 0 3 3 3 0 GHKL domain HATPase_c_3 PF13589.6 AIF84387.1 - 0.074 12.9 0.1 0.21 11.4 0.1 1.8 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TackOD1 PF18551.1 AIF84388.1 - 0.013 15.2 0.5 0.013 15.2 0.5 1.0 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Paired_CXXCH_1 PF09699.10 AIF84388.1 - 0.032 14.0 2.2 0.087 12.6 0.2 2.0 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) zf-dskA_traR PF01258.17 AIF84388.1 - 0.048 13.6 1.3 4.2 7.4 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger A2L_zn_ribbon PF08792.10 AIF84388.1 - 0.05 13.3 4.0 0.37 10.6 0.2 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-piccolo PF05715.13 AIF84388.1 - 0.22 11.7 3.9 2.2 8.5 3.6 2.0 1 1 1 2 2 2 0 Piccolo Zn-finger zinc_ribbon_13 PF09855.9 AIF84388.1 - 0.29 11.3 4.0 0.92 9.7 0.3 2.1 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) DUF192 PF02643.15 AIF84389.1 - 7.5e-20 70.9 0.0 9.8e-20 70.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 Arch_flagellin PF01917.16 AIF84390.1 - 6.2e-22 78.5 8.7 8.5e-22 78.1 8.7 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin Regulator_TrmB PF11495.8 AIF84391.1 - 3.3e-12 46.1 0.1 7.7e-05 22.0 0.1 2.3 2 0 0 2 2 2 2 Archaeal transcriptional regulator TrmB TrmB PF01978.19 AIF84391.1 - 7.3e-12 45.0 0.0 2e-11 43.6 0.0 1.8 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB PLDc_2 PF13091.6 AIF84391.1 - 0.001 19.0 0.1 0.029 14.3 0.0 2.7 2 1 0 2 2 2 1 PLD-like domain MarR PF01047.22 AIF84391.1 - 0.0035 17.2 0.0 0.0094 15.9 0.0 1.8 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 AIF84391.1 - 0.0073 16.2 0.2 0.028 14.3 0.2 2.0 1 0 0 1 1 1 1 MarR family HTH_IclR PF09339.10 AIF84391.1 - 0.0076 16.0 0.1 0.021 14.6 0.1 1.8 1 0 0 1 1 1 1 IclR helix-turn-helix domain PP_kinase_C PF13090.6 AIF84391.1 - 0.023 14.2 0.0 1.9 7.9 0.0 2.7 2 0 0 2 2 2 0 Polyphosphate kinase C-terminal domain 2 HTH_Crp_2 PF13545.6 AIF84391.1 - 0.091 12.8 0.2 0.48 10.4 0.1 2.2 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_7 PF02796.15 AIF84391.1 - 0.1 12.7 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase MCPsignal PF00015.21 AIF84392.1 - 2.1e-41 141.6 58.2 5.3e-41 140.3 24.3 4.3 1 1 3 4 4 4 3 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 AIF84392.1 - 1.1e-15 57.8 3.2 1e-12 48.3 0.0 4.7 4 0 0 4 4 4 1 HAMP domain dCache_1 PF02743.18 AIF84392.1 - 3e-11 43.6 0.1 3e-11 43.6 0.1 4.1 3 2 1 4 4 4 1 Cache domain sCache_3_2 PF17203.4 AIF84392.1 - 0.098 12.8 0.0 0.098 12.8 0.0 4.2 4 1 1 5 5 5 0 Single cache domain 3 Spc7 PF08317.11 AIF84392.1 - 0.3 9.9 26.9 0.4 9.5 15.2 2.9 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF948 PF06103.11 AIF84392.1 - 0.6 10.4 32.6 6.2 7.2 5.1 5.4 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Syntaxin_2 PF14523.6 AIF84392.1 - 3.1 8.2 22.3 3.9 7.9 3.0 5.0 3 1 3 6 6 6 0 Syntaxin-like protein Hormone_1 PF00103.20 AIF84392.1 - 4.5 6.9 11.9 1.5 8.5 0.3 3.3 2 1 1 3 3 3 0 Somatotropin hormone family ING PF12998.7 AIF84392.1 - 6.1 7.5 10.1 11 6.7 1.0 3.2 2 2 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DASH_Dad1 PF08649.10 AIF84392.1 - 7 6.9 7.6 6.6 7.0 0.2 4.2 3 2 1 4 4 4 0 DASH complex subunit Dad1 MCPsignal PF00015.21 AIF84395.1 - 9.5e-14 51.6 2.1 1.6e-13 50.8 2.1 1.3 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 AIF84395.1 - 5.7e-12 46.0 0.3 8e-12 45.5 0.0 1.4 2 0 0 2 2 2 1 Cache domain sCache_like PF16736.5 AIF84395.1 - 0.00086 19.4 0.4 0.06 13.4 0.0 3.1 3 1 0 3 3 3 1 Single Cache-like Diacid_rec PF05651.13 AIF84395.1 - 0.019 14.7 0.0 0.4 10.4 0.0 2.7 2 0 0 2 2 2 0 Putative sugar diacid recognition DUF4402 PF14352.6 AIF84396.1 - 0.065 13.9 0.0 0.066 13.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4402) CheW PF01584.19 AIF84397.1 - 1.6e-31 108.8 1.4 1.9e-31 108.5 1.4 1.0 1 0 0 1 1 1 1 CheW-like domain Response_reg PF00072.24 AIF84398.1 - 1e-30 106.2 1.9 1.2e-30 106.0 1.9 1.0 1 0 0 1 1 1 1 Response regulator receiver domain DUF3798 PF12683.7 AIF84398.1 - 0.017 14.5 0.5 0.022 14.2 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) CheB_methylest PF01339.17 AIF84399.1 - 5.9e-56 188.8 0.2 2.5e-55 186.8 0.1 1.9 2 0 0 2 2 2 1 CheB methylesterase Response_reg PF00072.24 AIF84399.1 - 5.1e-19 68.5 0.1 1.1e-18 67.4 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain DUF3798 PF12683.7 AIF84399.1 - 0.014 14.8 0.0 0.029 13.8 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3798) CheW PF01584.19 AIF84400.1 - 5.1e-21 74.8 0.3 9.1e-21 73.9 0.3 1.4 1 0 0 1 1 1 1 CheW-like domain Hpt PF01627.23 AIF84400.1 - 7.5e-20 71.0 0.4 2.3e-19 69.4 0.4 1.9 1 0 0 1 1 1 1 Hpt domain HATPase_c PF02518.26 AIF84400.1 - 3.4e-18 66.2 0.2 1e-17 64.6 0.2 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase H-kinase_dim PF02895.14 AIF84400.1 - 2.3e-11 43.9 3.0 3.3e-11 43.4 1.0 2.4 2 0 0 2 2 2 1 Signal transducing histidine kinase, homodimeric domain Snf7 PF03357.21 AIF84400.1 - 3.7e-05 23.4 2.5 0.00012 21.7 2.5 1.9 1 0 0 1 1 1 1 Snf7 HATPase_c_3 PF13589.6 AIF84400.1 - 0.0021 17.9 1.6 0.0091 15.8 1.6 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 AIF84400.1 - 0.13 12.2 0.2 0.36 10.8 0.1 1.9 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain LPD11 PF18824.1 AIF84400.1 - 0.21 11.7 1.6 27 4.9 0.0 3.1 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 11 Androgen_recep PF02166.16 AIF84400.1 - 8.2 5.1 6.7 11 4.7 2.7 2.6 3 0 0 3 3 3 0 Androgen receptor CheC PF04509.12 AIF84401.1 - 1.7e-07 31.0 0.1 4.3e-07 29.7 0.1 1.8 1 0 0 1 1 1 1 CheC-like family CheX PF13690.6 AIF84401.1 - 0.0024 18.0 0.0 0.0049 17.0 0.0 1.5 1 0 0 1 1 1 1 Chemotaxis phosphatase CheX CheD PF03975.13 AIF84402.1 - 2e-30 105.1 0.0 2.5e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 CheD chemotactic sensory transduction Cu-oxidase_4 PF02578.15 AIF84402.1 - 0.017 14.7 0.1 0.032 13.8 0.1 1.5 1 1 0 1 1 1 0 Multi-copper polyphenol oxidoreductase laccase CheR PF01739.18 AIF84403.1 - 9.4e-56 188.4 0.0 1.1e-55 188.1 0.0 1.1 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.15 AIF84403.1 - 3.6e-11 42.6 1.4 6.7e-11 41.7 1.4 1.4 1 0 0 1 1 1 1 CheR methyltransferase, all-alpha domain Methyltransf_31 PF13847.6 AIF84403.1 - 2.9e-06 27.1 0.2 0.07 12.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 AIF84403.1 - 6.3e-06 26.9 0.1 3.7e-05 24.4 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF84403.1 - 1e-05 26.0 0.1 0.00026 21.6 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF84403.1 - 1.7e-05 25.4 0.1 0.025 15.3 0.0 2.5 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_2 PF00891.18 AIF84403.1 - 0.0042 16.4 0.0 0.0069 15.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain T2SSE PF00437.20 AIF84404.1 - 5.5e-42 143.7 0.0 7.7e-42 143.2 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein TrmB PF01978.19 AIF84405.1 - 1.7e-13 50.2 0.2 6.3e-13 48.4 0.1 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 AIF84405.1 - 0.063 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_5 PF01022.20 AIF84405.1 - 0.066 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Arch_flagellin PF01917.16 AIF84406.1 - 1.9e-28 99.7 7.9 2.7e-28 99.2 7.9 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin Rad33 PF08730.10 AIF84406.1 - 0.011 15.7 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Rad33 Arch_flagellin PF01917.16 AIF84407.1 - 6.4e-24 85.0 14.9 8.7e-24 84.6 14.9 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin Spc7 PF08317.11 AIF84408.1 - 0.056 12.3 3.2 0.38 9.6 2.7 2.1 1 1 0 1 1 1 0 Spc7 kinetochore protein TolA_bind_tri PF16331.5 AIF84408.1 - 0.1 12.7 2.4 0.56 10.3 0.0 2.7 3 0 0 3 3 3 0 TolA binding protein trimerisation FlaC_arch PF05377.11 AIF84408.1 - 0.28 11.6 2.9 7.1 7.1 0.2 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 AIF84408.1 - 0.56 10.3 2.6 0.49 10.4 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Arch_flagellin PF01917.16 AIF84409.1 - 1.9e-11 44.4 5.9 2.4e-11 44.1 5.9 1.0 1 0 0 1 1 1 1 Archaebacterial flagellin ATPase PF06745.13 AIF84411.1 - 2.3e-21 76.2 0.1 2.7e-21 76.0 0.1 1.0 1 0 0 1 1 1 1 KaiC Rad51 PF08423.11 AIF84411.1 - 3.6e-06 26.4 0.0 4.8e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Rad51 PAXNEB PF05625.11 AIF84411.1 - 0.00039 19.7 0.5 0.01 15.0 0.1 2.1 2 0 0 2 2 2 1 PAXNEB protein AAA_16 PF13191.6 AIF84411.1 - 0.00041 20.8 0.0 0.00057 20.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 AIF84411.1 - 0.00058 19.5 0.0 0.00078 19.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AIF84411.1 - 0.00084 19.1 0.1 0.0013 18.5 0.1 1.2 1 0 0 1 1 1 1 AAA domain Elong_Iki1 PF10483.9 AIF84411.1 - 0.0026 17.3 0.5 0.0066 16.0 0.2 1.6 1 1 1 2 2 2 1 Elongator subunit Iki1 DUF835 PF05763.12 AIF84411.1 - 0.0033 17.1 0.2 0.0067 16.2 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF835) AAA_7 PF12775.7 AIF84411.1 - 0.0076 15.8 0.1 0.014 14.9 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region RAP1 PF07218.11 AIF84411.1 - 0.0077 14.6 0.1 0.011 14.1 0.1 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) AAA_14 PF13173.6 AIF84411.1 - 0.0098 15.9 0.3 0.024 14.7 0.3 1.6 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AIF84411.1 - 0.022 15.3 0.0 0.034 14.7 0.0 1.2 1 0 0 1 1 1 0 ABC transporter DUF815 PF05673.13 AIF84411.1 - 0.028 13.6 0.0 0.048 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Bac_DnaA PF00308.18 AIF84411.1 - 0.03 14.2 0.1 2 8.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein Ras PF00071.22 AIF84411.1 - 0.032 13.8 0.0 0.067 12.8 0.0 1.5 1 0 0 1 1 1 0 Ras family NACHT PF05729.12 AIF84411.1 - 0.045 13.7 0.1 0.11 12.4 0.1 1.6 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 AIF84411.1 - 0.053 13.4 0.0 0.076 12.9 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea MinE PF03776.14 AIF84411.1 - 0.06 13.4 0.2 0.16 12.0 0.2 1.8 1 1 0 1 1 1 0 Septum formation topological specificity factor MinE RNA_helicase PF00910.22 AIF84411.1 - 0.073 13.5 0.1 0.17 12.3 0.0 1.7 2 0 0 2 2 1 0 RNA helicase IstB_IS21 PF01695.17 AIF84411.1 - 0.09 12.5 0.1 0.31 10.7 0.0 2.0 1 1 1 2 2 2 0 IstB-like ATP binding protein T2SSF PF00482.23 AIF84412.1 - 1.6e-06 28.1 10.3 3.2e-05 23.9 0.4 3.2 3 0 0 3 3 3 2 Type II secretion system (T2SS), protein F Abhydrolase_9_N PF15420.6 AIF84412.1 - 0.057 13.4 1.8 0.094 12.7 0.0 2.2 2 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus NitrOD5 PF11537.8 AIF84413.1 - 1.6e-06 28.1 0.0 2.8e-06 27.4 0.0 1.4 1 1 0 1 1 1 1 Nitrosopumilus output domain 5 RRM_1 PF00076.22 AIF84413.1 - 0.029 14.2 0.0 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NitrOD2 PF18550.1 AIF84413.1 - 0.15 12.2 0.0 0.21 11.7 0.0 1.3 1 1 0 1 1 1 0 Nitrososphaera output domain 2 DUF4423 PF14394.6 AIF84414.1 - 0.082 12.6 0.1 0.12 12.1 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4423) ATPase PF06745.13 AIF84415.1 - 3.2e-52 177.2 2.3 9.3e-52 175.7 2.3 1.6 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 AIF84415.1 - 7.3e-06 25.5 0.2 3.4e-05 23.3 0.0 1.8 1 1 1 2 2 2 1 DnaB-like helicase C terminal domain RecA PF00154.21 AIF84415.1 - 1e-05 25.2 0.0 1.5e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_14 PF13173.6 AIF84415.1 - 3.1e-05 24.0 0.2 0.00017 21.7 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 AIF84415.1 - 5.2e-05 22.9 0.0 9e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 AIF84415.1 - 0.00013 21.8 0.1 0.00067 19.4 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 AIF84415.1 - 0.00021 21.7 0.0 0.00031 21.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 AIF84415.1 - 0.00024 20.5 0.0 0.0003 20.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Rad51 PF08423.11 AIF84415.1 - 0.00031 20.1 0.2 0.00061 19.1 0.2 1.5 1 1 0 1 1 1 1 Rad51 AAA_24 PF13479.6 AIF84415.1 - 0.00074 19.3 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.17 AIF84415.1 - 0.0054 15.9 0.2 0.021 13.9 0.1 1.8 1 1 1 2 2 2 1 Parvovirus non-structural protein NS1 GvpD PF07088.11 AIF84415.1 - 0.007 15.0 0.6 0.094 11.3 0.6 2.1 1 1 0 1 1 1 1 GvpD gas vesicle protein AAA_18 PF13238.6 AIF84415.1 - 0.0072 16.9 0.0 0.013 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 AIF84415.1 - 0.01 15.3 0.5 0.075 12.5 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 AIF84415.1 - 0.015 15.6 0.1 0.03 14.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 AIF84415.1 - 0.019 14.2 0.2 0.042 13.1 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_19 PF13245.6 AIF84415.1 - 0.019 15.3 0.6 0.12 12.8 0.6 2.1 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 AIF84415.1 - 0.02 14.7 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase NACHT PF05729.12 AIF84415.1 - 0.022 14.7 0.0 0.053 13.4 0.0 1.6 1 1 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 AIF84415.1 - 0.078 13.2 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 AIF84415.1 - 0.13 11.9 0.1 0.21 11.3 0.1 1.4 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 AIF84415.1 - 0.15 12.1 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_7 PF12775.7 AIF84415.1 - 0.16 11.4 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region PIF1 PF05970.14 AIF84415.1 - 0.47 9.6 2.5 2.7 7.1 0.2 2.1 1 1 1 2 2 2 0 PIF1-like helicase LRR_3 PF07725.12 AIF84415.1 - 0.64 10.0 3.7 11 6.1 0.0 2.9 3 0 0 3 3 3 0 Leucine Rich Repeat MASE3 PF17159.4 AIF84416.1 - 7.3e-12 45.4 18.8 1.2e-11 44.7 18.8 1.3 1 0 0 1 1 1 1 Membrane-associated sensor domain TrmB PF01978.19 AIF84418.1 - 2.4e-13 49.8 0.1 1.1e-12 47.6 0.1 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 AIF84418.1 - 0.0017 17.6 0.4 0.0089 15.2 0.1 1.9 2 0 0 2 2 2 1 Archaeal transcriptional regulator TrmB DUF5009 PF16401.5 AIF84419.1 - 0.031 13.8 0.2 0.033 13.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5009) Arc_PepC_II PF06847.11 AIF84420.1 - 2.7e-07 31.0 1.6 2e-06 28.2 1.6 2.1 2 1 0 2 2 2 1 Archaeal Peptidase A24 C-terminus Type II Peptidase_A24 PF01478.18 AIF84420.1 - 2.8e-05 24.5 8.3 2.8e-05 24.5 8.3 2.1 2 1 0 2 2 2 1 Type IV leader peptidase family TRAM_LAG1_CLN8 PF03798.16 AIF84421.1 - 0.077 12.7 0.2 0.092 12.5 0.2 1.1 1 0 0 1 1 1 0 TLC domain Putative_PNPOx PF01243.20 AIF84422.1 - 1.2e-14 54.3 0.0 1.6e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AIF84422.1 - 6.9e-10 39.1 0.0 1.1e-09 38.4 0.0 1.3 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIF84422.1 - 0.00057 19.5 0.0 0.00073 19.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like AMP-binding PF00501.28 AIF84423.1 - 6e-98 328.2 0.1 7.4e-98 327.9 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AIF84423.1 - 1.1e-23 84.0 0.5 1.1e-23 84.0 0.5 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AIF84423.1 - 6.1e-22 77.3 0.5 1.8e-21 75.8 0.5 1.9 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus MethyltransfD12 PF02086.15 AIF84424.1 - 1.1e-41 143.2 0.0 1.5e-41 142.8 0.0 1.1 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Cons_hypoth95 PF03602.15 AIF84424.1 - 0.1 12.2 0.0 2.1 7.9 0.1 2.5 2 1 1 3 3 3 0 Conserved hypothetical protein 95 CBFD_NFYB_HMF PF00808.23 AIF84426.1 - 8.1e-15 54.9 1.1 9.7e-15 54.6 1.1 1.0 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AIF84426.1 - 1.2e-08 35.3 0.2 1.4e-08 35.1 0.2 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 AIF84426.1 - 3.9e-07 30.2 0.2 4.2e-07 30.0 0.2 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 AIF84426.1 - 1.3e-05 25.4 0.0 1.4e-05 25.4 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein TAF PF02969.17 AIF84426.1 - 0.00022 21.3 0.5 0.00024 21.2 0.5 1.1 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Bromo_TP PF07524.13 AIF84426.1 - 0.00039 20.4 0.0 0.00048 20.1 0.0 1.0 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 AIF84426.1 - 0.014 15.5 0.0 0.015 15.4 0.0 1.0 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TFIIB PF00382.19 AIF84426.1 - 0.026 14.6 0.1 0.035 14.1 0.1 1.3 1 0 0 1 1 1 0 Transcription factor TFIIB repeat TatD_DNase PF01026.21 AIF84427.1 - 6.2e-43 147.0 0.0 7.5e-43 146.7 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Ribosomal_S17e PF00833.18 AIF84428.1 - 2.4e-15 56.5 0.4 2.6e-15 56.4 0.4 1.0 1 0 0 1 1 1 1 Ribosomal S17 CGI-121 PF08617.10 AIF84429.1 - 6.4e-08 32.9 0.0 9.5e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Kinase binding protein CGI-121 ThiS PF02597.20 AIF84429.1 - 7.4e-08 32.9 0.3 2.4e-07 31.3 0.0 2.0 3 0 0 3 3 3 1 ThiS family Imm51 PF15595.6 AIF84429.1 - 0.041 13.8 0.0 0.08 12.9 0.0 1.6 1 1 0 1 1 1 0 Immunity protein 51 Urm1 PF09138.11 AIF84429.1 - 0.051 13.9 0.0 0.17 12.2 0.0 2.0 1 1 0 1 1 1 0 Urm1 (Ubiquitin related modifier) THUMP PF02926.17 AIF84430.1 - 1.3e-15 57.8 0.5 1.6e-15 57.5 0.5 1.2 1 0 0 1 1 1 1 THUMP domain Sua5_yciO_yrdC PF01300.18 AIF84431.1 - 2.1e-46 157.7 0.0 2.4e-46 157.5 0.0 1.0 1 0 0 1 1 1 1 Telomere recombination Hydantoinase_A PF01968.18 AIF84432.1 - 1.6e-58 198.3 4.8 1.6e-58 198.3 4.8 2.1 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 AIF84432.1 - 2.6e-21 76.2 13.3 2.9e-21 76.0 3.3 3.8 5 1 0 5 5 5 2 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.6 AIF84432.1 - 2.5e-06 26.4 4.3 0.00021 20.0 1.3 2.4 2 0 0 2 2 2 2 MutL protein BcrAD_BadFG PF01869.20 AIF84432.1 - 0.00021 20.9 8.5 0.00049 19.7 0.6 3.8 3 1 1 4 4 4 1 BadF/BadG/BcrA/BcrD ATPase family FGGY_N PF00370.21 AIF84432.1 - 0.00021 20.9 0.8 0.00055 19.6 0.8 1.7 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FtsA PF14450.6 AIF84432.1 - 0.077 13.4 5.5 1.4 9.4 0.3 3.4 3 0 0 3 3 3 0 Cell division protein FtsA DUF5362 PF17319.2 AIF84433.1 - 0.014 15.2 0.4 0.037 13.9 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5362) DHHC PF01529.20 AIF84433.1 - 0.95 9.6 4.5 0.33 11.1 1.4 1.7 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF4519 PF15012.6 AIF84434.1 - 0.015 15.5 1.8 0.032 14.4 1.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) DUF4328 PF14219.6 AIF84434.1 - 0.1 12.1 0.5 0.1 12.1 0.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4328) UcrQ PF02939.16 AIF84434.1 - 0.18 11.7 2.7 8.8 6.3 0.1 2.3 2 0 0 2 2 2 0 UcrQ family CD20 PF04103.15 AIF84439.1 - 3.1 7.9 4.5 23 5.1 4.5 2.4 1 1 0 1 1 1 0 CD20-like family DUF2387 PF09526.10 AIF84440.1 - 0.0016 18.5 0.7 0.0016 18.5 0.7 1.8 2 0 0 2 2 2 1 Probable metal-binding protein (DUF2387) zf-RING_4 PF14570.6 AIF84440.1 - 0.022 14.5 0.8 0.022 14.5 0.8 2.1 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.12 AIF84440.1 - 0.39 10.7 7.4 0.11 12.5 2.6 2.3 1 1 1 2 2 2 0 zinc-ribbons zf-HIT PF04438.16 AIF84440.1 - 1.4 8.8 13.3 8.9 6.3 0.2 4.1 4 0 0 4 4 4 0 HIT zinc finger zf-C3HC4_3 PF13920.6 AIF84440.1 - 4.9 7.1 15.3 47 4.0 10.1 3.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) V4R PF02830.18 AIF84441.1 - 1.5e-13 50.6 0.7 2.3e-13 49.9 0.7 1.3 1 0 0 1 1 1 1 V4R domain HTH_AsnC-type PF13404.6 AIF84442.1 - 1.8e-07 30.9 0.8 5.7e-07 29.3 0.1 2.2 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 AIF84442.1 - 2.7e-06 26.8 0.8 2.7e-06 26.8 0.8 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_50 PF18024.1 AIF84442.1 - 0.012 15.2 0.1 0.03 13.9 0.1 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain Sipho_tail PF05709.11 AIF84442.1 - 0.038 13.4 0.1 0.056 12.8 0.1 1.2 1 0 0 1 1 1 0 Phage tail protein HTH_psq PF05225.16 AIF84442.1 - 0.043 13.6 0.0 0.082 12.7 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain DUF2459 PF09601.10 AIF84442.1 - 0.056 13.3 0.0 0.069 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2459) HTH_8 PF02954.19 AIF84442.1 - 0.11 12.3 0.2 0.27 11.0 0.2 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family TrmB PF01978.19 AIF84442.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB UDPG_MGDP_dh PF00984.19 AIF84443.1 - 3.1e-20 72.2 0.1 4.8e-20 71.6 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 AIF84443.1 - 9.2e-08 31.9 0.0 0.002 17.7 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 AIF84443.1 - 0.0018 18.5 0.1 0.0043 17.3 0.1 1.7 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.15 AIF84443.1 - 0.01 16.0 0.0 0.016 15.4 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 AIF84443.1 - 0.014 14.7 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 AIF84443.1 - 0.029 14.3 0.2 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HTH_45 PF14947.6 AIF84444.1 - 1.1e-15 57.4 0.1 1.3e-15 57.1 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix Mrr_N PF14338.6 AIF84444.1 - 0.037 14.2 0.1 0.046 13.8 0.1 1.2 1 0 0 1 1 1 0 Mrr N-terminal domain Big_7 PF17957.1 AIF84445.1 - 3.2e-13 50.2 14.7 2.9e-06 27.9 3.9 4.4 3 1 1 4 4 4 2 Bacterial Ig domain Gmad2 PF10648.9 AIF84445.1 - 2.3e-06 27.8 1.4 0.0026 18.0 0.6 3.0 2 0 0 2 2 2 2 Immunoglobulin-like domain of bacterial spore germination Big_1 PF02369.16 AIF84445.1 - 3.1e-05 23.9 0.1 3.1e-05 23.9 0.1 5.3 5 2 0 5 5 5 1 Bacterial Ig-like domain (group 1) Big_3_4 PF13754.6 AIF84445.1 - 0.013 15.3 0.2 0.78 9.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function CarboxypepD_reg PF13620.6 AIF84445.1 - 0.014 15.6 0.1 0.014 15.6 0.1 3.7 3 1 0 3 3 3 0 Carboxypeptidase regulatory-like domain PKD PF00801.20 AIF84445.1 - 0.039 13.8 7.1 0.074 12.9 2.0 3.4 4 1 0 4 4 4 0 PKD domain YbbR PF07949.12 AIF84445.1 - 0.42 11.0 4.7 25 5.3 0.0 4.1 4 1 0 4 4 4 0 YbbR-like protein HTH_24 PF13412.6 AIF84446.1 - 2.7e-06 26.8 0.4 5.6e-06 25.8 0.4 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF84446.1 - 0.0012 18.6 0.2 0.0025 17.6 0.2 1.6 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.12 AIF84446.1 - 0.0015 18.4 0.1 0.0034 17.3 0.1 1.5 1 0 0 1 1 1 1 HTH domain HTH_23 PF13384.6 AIF84446.1 - 0.012 15.3 0.0 0.033 14.0 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_20 PF12840.7 AIF84446.1 - 0.016 15.2 0.1 0.038 14.0 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain AsnC_trans_reg PF01037.21 AIF84446.1 - 0.016 15.1 0.0 0.036 14.0 0.0 1.6 1 0 0 1 1 1 0 Lrp/AsnC ligand binding domain HTH_8 PF02954.19 AIF84446.1 - 0.047 13.5 0.0 0.14 11.9 0.0 1.9 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family TrmB PF01978.19 AIF84446.1 - 0.064 13.1 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 AIF84447.1 - 1.6e-06 27.5 1.8 8.1e-06 25.3 0.2 2.6 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF84447.1 - 0.00074 19.3 0.1 0.0074 16.1 0.1 2.4 2 1 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.12 AIF84447.1 - 0.0011 18.9 0.2 0.0026 17.7 0.2 1.7 1 0 0 1 1 1 1 HTH domain HTH_20 PF12840.7 AIF84447.1 - 0.002 18.2 0.5 0.0097 15.9 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 AIF84447.1 - 0.01 15.6 0.0 0.03 14.1 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain TrmB PF01978.19 AIF84447.1 - 0.029 14.3 0.1 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB ACT_4 PF13291.6 AIF84447.1 - 0.066 13.8 0.6 0.23 12.1 0.1 2.2 3 1 0 3 3 3 0 ACT domain SIS PF01380.22 AIF84449.1 - 1.9e-53 179.8 2.3 3.3e-30 104.6 1.8 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 AIF84449.1 - 3.5e-22 79.0 0.0 7.5e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AIF84449.1 - 4.3e-16 58.9 0.0 9.1e-16 57.9 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 AIF84449.1 - 0.00011 22.2 5.3 0.00019 21.5 0.9 3.0 2 1 1 3 3 3 1 SIS domain GATase_4 PF13230.6 AIF84449.1 - 0.015 14.2 0.3 0.045 12.6 0.1 1.8 2 0 0 2 2 2 0 Glutamine amidotransferases class-II F5_F8_type_C PF00754.25 AIF84452.1 - 7.5e-17 61.6 2.1 4e-16 59.3 2.1 2.3 1 0 0 1 1 1 1 F5/8 type C domain Sad1_UNC PF07738.13 AIF84452.1 - 0.0054 16.7 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Cadherin-like PF12733.7 AIF84452.1 - 0.61 10.6 3.9 1.2 9.7 0.3 2.7 1 1 1 2 2 2 0 Cadherin-like beta sandwich domain Beta_helix PF13229.6 AIF84453.1 - 1.8e-17 63.7 42.0 6.1e-10 39.2 14.7 2.9 2 1 1 3 3 3 2 Right handed beta helix region NosD PF05048.13 AIF84453.1 - 2.7e-15 56.3 23.1 2.7e-15 56.3 23.1 2.3 2 1 0 2 2 2 1 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.11 AIF84453.1 - 0.013 14.9 16.9 0.047 13.0 15.2 2.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1565) Polysacc_deac_1 PF01522.21 AIF84453.1 - 0.023 14.6 0.0 0.056 13.3 0.0 1.6 1 0 0 1 1 1 0 Polysaccharide deacetylase Glycos_transf_2 PF00535.26 AIF84454.1 - 4.4e-30 104.7 0.1 9.4e-30 103.6 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIF84454.1 - 4.6e-20 72.5 0.1 1.1e-19 71.3 0.0 1.6 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 AIF84454.1 - 2e-16 59.7 0.2 4.5e-15 55.3 0.2 2.1 1 1 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 AIF84454.1 - 2.9e-09 37.1 3.9 2.9e-09 37.1 3.9 2.2 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 AIF84454.1 - 6.3e-09 35.5 2.7 7.3e-07 28.8 0.0 2.6 3 0 0 3 3 3 2 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 AIF84454.1 - 1.1e-05 25.0 0.0 1.6e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 MARVEL PF01284.23 AIF84454.1 - 0.41 10.7 6.6 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 Membrane-associating domain YjgF_endoribonc PF14588.6 AIF84455.1 - 2.9e-42 144.3 0.0 3.2e-42 144.2 0.0 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.21 AIF84455.1 - 1.2e-22 80.1 0.1 1.8e-22 79.6 0.1 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP DHHA1 PF02272.19 AIF84456.1 - 4.7e-16 59.4 0.3 1.1e-15 58.2 0.3 1.7 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.20 AIF84456.1 - 0.00078 19.6 0.1 0.0017 18.5 0.1 1.6 1 0 0 1 1 1 1 DHH family HMGL-like PF00682.19 AIF84456.1 - 0.022 14.3 0.1 0.039 13.5 0.1 1.4 1 0 0 1 1 1 0 HMGL-like Thioredox_DsbH PF03190.15 AIF84457.1 - 1.4e-75 252.7 0.0 2.2e-75 252.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Glyco_hydro_88 PF07470.13 AIF84457.1 - 3.8e-12 46.0 0.3 8.7e-05 21.7 0.0 2.9 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 Thioredoxin_7 PF13899.6 AIF84457.1 - 6.5e-11 42.3 0.0 1.5e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Glyco_hydro_76 PF03663.14 AIF84457.1 - 3.9e-08 33.2 0.1 4.9e-07 29.6 0.1 2.6 2 1 0 2 2 2 1 Glycosyl hydrolase family 76 C5-epim_C PF06662.13 AIF84457.1 - 2.4e-06 27.2 1.1 0.031 13.8 0.0 4.0 4 1 0 4 4 4 2 D-glucuronyl C5-epimerase C-terminus GlcNAc_2-epim PF07221.11 AIF84457.1 - 0.00046 19.5 0.3 0.053 12.8 0.1 2.7 2 1 0 2 2 2 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Glyco_hydro_127 PF07944.12 AIF84457.1 - 0.0045 15.5 0.0 0.14 10.6 0.0 2.6 2 1 1 3 3 3 1 Beta-L-arabinofuranosidase, GH127 PMBR PF09373.10 AIF84457.1 - 0.034 14.3 0.4 10 6.4 0.0 3.4 3 0 0 3 3 3 0 Pseudomurein-binding repeat Pec_lyase PF09492.10 AIF84457.1 - 0.034 13.5 0.0 8.1 5.7 0.0 2.4 2 0 0 2 2 2 0 Pectic acid lyase Thioredoxin_2 PF13098.6 AIF84457.1 - 0.059 13.8 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like domain DUF5106 PF17127.4 AIF84457.1 - 0.096 13.0 0.2 0.39 11.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5106) Arcadin_1 PF18653.1 AIF84458.1 - 0.0078 16.3 2.4 0.009 16.1 2.4 1.1 1 0 0 1 1 1 1 Arcadin 1 KdpD PF02702.17 AIF84458.1 - 0.0086 15.6 0.8 0.011 15.2 0.8 1.0 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain Popeye PF04831.13 AIF84459.1 - 0.012 15.8 0.0 0.013 15.7 0.0 1.0 1 0 0 1 1 1 0 Popeye protein conserved region MitoNEET_N PF10660.9 AIF84459.1 - 0.1 12.6 0.1 6 7.0 0.2 2.1 2 0 0 2 2 2 0 Iron-containing outer mitochondrial membrane protein N-terminus Pyridox_ox_2 PF12900.7 AIF84460.1 - 2.4e-23 82.7 0.0 3e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 AIF84460.1 - 5.6e-13 48.9 0.0 1.3e-12 47.7 0.0 1.6 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.12 AIF84460.1 - 7.7e-06 25.7 0.0 9.1e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain HTH_45 PF14947.6 AIF84462.1 - 3e-19 68.8 0.4 3.3e-19 68.6 0.4 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIF84462.1 - 0.0032 17.2 0.0 0.0034 17.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) FokI_C PF02980.16 AIF84462.1 - 0.12 12.4 0.2 0.57 10.2 0.1 1.8 1 1 1 2 2 2 0 Restriction endonuclease FokI, catalytic domain PadR PF03551.14 AIF84463.1 - 1e-10 41.4 0.0 5e-10 39.2 0.0 2.0 1 1 1 2 2 2 1 Transcriptional regulator PadR-like family HTH_45 PF14947.6 AIF84463.1 - 0.00037 20.4 0.0 0.00083 19.3 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix RTP PF02334.16 AIF84463.1 - 0.029 15.0 0.0 0.055 14.1 0.0 1.5 1 0 0 1 1 1 0 Replication terminator protein FrhB_FdhB_N PF04422.13 AIF84463.1 - 0.065 13.4 0.2 4.3 7.5 0.0 2.7 2 1 1 3 3 3 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term MEDS PF14417.6 AIF84465.1 - 1.4e-09 38.0 0.0 5.3e-09 36.1 0.0 2.0 2 1 0 2 2 2 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain ATPase PF06745.13 AIF84465.1 - 0.014 14.8 0.0 0.027 13.8 0.0 1.5 1 1 0 1 1 1 0 KaiC MM_CoA_mutase PF01642.22 AIF84465.1 - 0.089 11.3 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl-CoA mutase PAP2 PF01569.21 AIF84466.1 - 2e-18 66.5 4.1 2e-18 66.5 4.1 2.2 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 AIF84466.1 - 3.1e-06 27.0 10.0 2.2e-05 24.2 10.0 2.3 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 AIF84466.1 - 0.072 13.6 0.2 0.072 13.6 0.2 2.5 3 1 0 3 3 3 0 PAP2 superfamily C-terminal DUF212 PF02681.14 AIF84466.1 - 3.1 7.9 6.2 7.2 6.8 0.3 2.9 2 1 0 3 3 3 0 Divergent PAP2 family DUF4396 PF14342.6 AIF84467.1 - 6.6e-31 107.6 11.8 7.5e-31 107.4 11.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) DUF2062 PF09835.9 AIF84467.1 - 1.4 8.7 10.8 42 4.0 10.3 2.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) UPF0086 PF01868.16 AIF84470.1 - 0.00024 20.9 0.0 0.31 11.0 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function UPF0086 Na_H_Exchanger PF00999.21 AIF84471.1 - 2.4e-61 207.6 49.5 2.7e-61 207.5 49.5 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TauE PF01925.19 AIF84473.1 - 4.2e-31 108.4 17.5 4.7e-31 108.2 17.5 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE CRCB PF02537.15 AIF84474.1 - 1.3e-19 70.3 6.4 1.6e-19 70.0 6.4 1.1 1 0 0 1 1 1 1 CrcB-like protein, Camphor Resistance (CrcB) DUF2104 PF09877.9 AIF84474.1 - 0.061 13.6 1.1 0.087 13.1 0.4 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2104) Phage_holin_5_2 PF16079.5 AIF84474.1 - 0.24 11.8 0.1 0.24 11.8 0.1 2.2 2 1 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V CPP1-like PF11833.8 AIF84474.1 - 2.5 7.7 6.9 1.9 8.1 2.9 1.9 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF190 PF02641.15 AIF84475.1 - 1.7e-21 76.3 0.0 1.9e-21 76.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1993 Cation_efflux PF01545.21 AIF84476.1 - 2.6e-38 131.8 14.5 3.1e-38 131.5 14.5 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 AIF84476.1 - 3.1e-10 40.0 0.1 6e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter YesK PF14150.6 AIF84477.1 - 3.3 8.0 11.6 1.3 9.3 0.3 2.8 2 1 0 2 2 2 0 YesK-like protein FBPase PF00316.20 AIF84478.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase, N-terminal domain DUF3040 PF11239.8 AIF84479.1 - 0.056 13.7 1.2 0.065 13.5 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Thioredoxin_4 PF13462.6 AIF84480.1 - 1.8e-32 112.8 0.0 2.6e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 AIF84480.1 - 3.3e-14 53.1 1.5 4.9e-13 49.3 0.4 2.4 2 1 0 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 AIF84480.1 - 1.8e-06 28.3 0.1 1.3e-05 25.6 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_5 PF13743.6 AIF84480.1 - 0.03 14.0 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin ETRAMP PF09716.10 AIF84480.1 - 0.29 11.2 1.2 0.52 10.4 1.2 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DHR10 PF18595.1 AIF84481.1 - 0.0058 16.7 13.7 0.0058 16.7 13.7 3.6 3 1 0 3 3 3 1 Designed helical repeat protein 10 domain YkyA PF10368.9 AIF84481.1 - 0.059 13.0 21.6 0.91 9.2 8.4 3.3 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein GRDP-like PF07173.12 AIF84481.1 - 0.09 13.4 1.6 0.24 12.1 1.6 1.7 1 0 0 1 1 1 0 Glycine-rich domain-containing protein-like TMF_TATA_bd PF12325.8 AIF84481.1 - 0.17 12.1 30.9 0.92 9.8 7.9 4.4 3 2 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4263 PF14082.6 AIF84481.1 - 0.23 11.7 0.1 0.23 11.7 0.1 2.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4263) DUF948 PF06103.11 AIF84481.1 - 0.32 11.3 9.7 6.4 7.1 0.2 5.2 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF948) MapZ_EC1 PF18041.1 AIF84481.1 - 0.35 11.1 7.5 0.051 13.8 2.0 2.5 3 0 0 3 3 3 0 MapZ extracellular domain 1 DUF677 PF05055.12 AIF84481.1 - 0.53 9.1 9.9 0.28 10.0 1.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF677) FlaC_arch PF05377.11 AIF84481.1 - 0.83 10.1 10.8 10 6.6 0.1 5.6 5 2 2 7 7 7 0 Flagella accessory protein C (FlaC) DUF4055 PF13264.6 AIF84481.1 - 1.9 8.6 14.1 0.28 11.3 6.7 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4055) Baculo_PEP_C PF04513.12 AIF84481.1 - 2.3 8.2 16.4 3.2 7.8 5.0 4.3 4 2 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin-6_N PF09177.11 AIF84481.1 - 3.1 8.4 13.8 19 5.9 0.0 4.3 2 1 3 5 5 5 0 Syntaxin 6, N-terminal TolA_bind_tri PF16331.5 AIF84481.1 - 3.8 7.7 18.4 0.054 13.6 2.7 3.8 3 0 0 3 3 3 0 TolA binding protein trimerisation Cob_adeno_trans PF01923.18 AIF84481.1 - 5 7.2 15.4 1.7 8.8 4.9 3.8 2 2 0 3 3 3 0 Cobalamin adenosyltransferase Dynactin_p22 PF07426.11 AIF84481.1 - 7.8 6.3 17.2 0.098 12.5 3.7 3.8 3 2 1 4 4 4 0 Dynactin subunit p22 DUF2627 PF11118.8 AIF84482.1 - 0.00016 22.2 0.6 0.0011 19.4 0.4 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2627) CbtB PF09489.10 AIF84483.1 - 0.13 12.4 0.3 0.18 11.9 0.3 1.2 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) Cupin_2 PF07883.11 AIF84485.1 - 4.5e-11 42.3 0.0 6e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 AIF84485.1 - 1.2e-06 28.2 0.1 1.6e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 Cupin CENP-C_C PF11699.8 AIF84485.1 - 0.00029 21.0 0.0 0.00037 20.6 0.0 1.1 1 0 0 1 1 1 1 Mif2/CENP-C like AraC_binding PF02311.19 AIF84485.1 - 0.00032 20.6 0.0 0.00039 20.3 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain ARD PF03079.14 AIF84485.1 - 0.00086 19.5 0.1 0.0014 18.8 0.1 1.4 1 1 0 1 1 1 1 ARD/ARD' family Cupin_3 PF05899.12 AIF84485.1 - 0.0023 17.6 0.1 0.0073 16.0 0.1 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF861) DMSP_lyase PF16867.5 AIF84485.1 - 0.0047 16.6 0.0 0.0056 16.3 0.0 1.1 1 0 0 1 1 1 1 Dimethlysulfonioproprionate lyase Cupin_6 PF12852.7 AIF84485.1 - 0.025 14.3 0.0 0.029 14.1 0.0 1.1 1 0 0 1 1 1 0 Cupin Csm4_C PF17953.1 AIF84485.1 - 0.095 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 CRISPR Csm4 C-terminal domain PK_C PF02887.16 AIF84485.1 - 0.11 12.7 0.0 0.13 12.5 0.0 1.1 1 0 0 1 1 1 0 Pyruvate kinase, alpha/beta domain BNR_2 PF13088.6 AIF84486.1 - 4.2e-06 26.3 7.3 2e-05 24.1 1.8 3.5 1 1 2 3 3 3 1 BNR repeat-like domain Glyco_hydro_43 PF04616.14 AIF84486.1 - 0.00092 18.6 0.8 0.0038 16.6 0.2 2.1 1 1 1 2 2 2 1 Glycosyl hydrolases family 43 Ribosomal_L40e PF01020.17 AIF84487.1 - 0.0013 18.6 5.1 0.0015 18.4 5.1 1.1 1 0 0 1 1 1 1 Ribosomal L40e family DZR PF12773.7 AIF84487.1 - 0.012 15.6 1.2 0.014 15.4 1.2 1.2 1 0 0 1 1 1 0 Double zinc ribbon Paired_CXXCH_1 PF09699.10 AIF84487.1 - 0.14 11.9 3.6 0.18 11.6 0.2 2.1 1 1 1 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) zinc_ribbon_2 PF13240.6 AIF84487.1 - 0.15 11.8 4.3 0.25 11.1 4.3 1.4 1 0 0 1 1 1 0 zinc-ribbon domain HTH_45 PF14947.6 AIF84489.1 - 1.2e-17 63.7 0.6 1.9e-17 63.0 0.6 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix FaeA PF04703.12 AIF84489.1 - 0.093 13.1 0.3 0.21 12.0 0.1 1.7 1 1 0 1 1 1 0 FaeA-like protein DUF2613 PF11021.8 AIF84490.1 - 0.019 15.1 3.6 0.019 15.0 2.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2613) Adeno_E3_CR2 PF02439.15 AIF84490.1 - 1.5 8.6 4.8 2.8 7.8 4.8 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 rve PF00665.26 AIF84492.1 - 4.3e-20 72.1 0.0 7.1e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 AIF84492.1 - 1.8e-07 30.9 3.2 7.3e-07 28.9 0.3 3.0 2 1 0 2 2 2 1 Integrase core domain HTH_21 PF13276.6 AIF84492.1 - 0.0017 18.5 1.0 0.0017 18.5 1.0 2.4 3 0 0 3 3 3 1 HTH-like domain HTH_23 PF13384.6 AIF84492.1 - 0.0077 16.0 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 AIF84492.1 - 0.017 14.8 0.2 0.031 13.9 0.2 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 DUF3379 PF11859.8 AIF84492.1 - 0.17 11.1 0.0 6.2 6.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3379) rve_2 PF13333.6 AIF84492.1 - 0.4 10.9 5.3 0.9 9.8 0.1 2.9 3 0 0 3 3 3 0 Integrase core domain DDE_Tnp_1 PF01609.21 AIF84493.1 - 1.9e-10 40.7 1.6 3.3e-10 40.0 1.6 1.4 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_5 PF13737.6 AIF84493.1 - 0.011 16.1 0.0 0.029 14.7 0.0 1.7 2 0 0 2 2 2 0 Transposase DDE domain Hydrolase_3 PF08282.12 AIF84494.1 - 1.2e-05 25.3 0.0 2.1e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 AIF84494.1 - 0.026 13.6 0.0 0.93 8.6 0.0 2.1 2 0 0 2 2 2 0 Trehalose-phosphatase S6PP PF05116.13 AIF84494.1 - 0.085 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase TFIIB PF00382.19 AIF84495.1 - 4.6e-30 103.5 5.6 3.5e-16 59.0 0.5 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIF84495.1 - 6.6e-08 31.9 1.1 1.2e-07 31.1 1.1 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 AIF84495.1 - 0.0015 18.3 0.1 0.4 10.4 0.1 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain HTH_11 PF08279.12 AIF84495.1 - 0.0018 18.2 0.1 0.013 15.5 0.0 2.5 3 0 0 3 3 3 1 HTH domain Sigma70_r4 PF04545.16 AIF84495.1 - 0.0031 17.0 1.7 0.046 13.2 0.0 2.8 3 0 0 3 3 3 1 Sigma-70, region 4 HTH_DeoR PF08220.12 AIF84495.1 - 0.0032 17.2 0.1 0.0083 15.8 0.0 1.7 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.20 AIF84495.1 - 0.0073 16.6 0.1 0.52 10.7 0.0 2.5 2 0 0 2 2 2 1 Transcriptional regulator LacI PF00356.21 AIF84495.1 - 0.028 14.2 0.6 2.9 7.7 0.0 3.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family RB_B PF01857.20 AIF84495.1 - 0.075 13.1 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain HTH_Crp_2 PF13545.6 AIF84495.1 - 0.12 12.4 0.4 8.7 6.4 0.0 2.9 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain PEPCK_ATP PF01293.20 AIF84497.1 - 2.3e-213 709.0 0.0 2.7e-213 708.8 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.6 AIF84497.1 - 0.048 14.1 0.0 0.13 12.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain PALP PF00291.25 AIF84498.1 - 3.5e-64 217.0 0.0 4.3e-64 216.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DFP PF04127.15 AIF84498.1 - 0.06 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein RNA_pol_Rpc34 PF05158.12 AIF84499.1 - 0.00073 19.0 0.0 0.0027 17.2 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpc34 subunit OSTMP1 PF09777.9 AIF84499.1 - 0.0098 15.3 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 1 Osteopetrosis-associated transmembrane protein 1 precursor RPA_C PF08784.11 AIF84499.1 - 0.023 15.3 0.0 0.041 14.5 0.0 1.3 1 0 0 1 1 1 0 Replication protein A C terminal Rrf2 PF02082.20 AIF84499.1 - 0.025 14.9 0.0 0.045 14.1 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator TrmB PF01978.19 AIF84499.1 - 0.036 13.9 0.0 0.081 12.8 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HisG_C PF08029.11 AIF84499.1 - 0.038 14.1 0.0 0.084 13.0 0.0 1.6 1 0 0 1 1 1 0 HisG, C-terminal domain Proton_antipo_M PF00361.20 AIF84500.1 - 2.5e-56 191.0 24.2 2.5e-56 191.0 24.2 2.6 3 1 0 3 3 3 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 AIF84500.1 - 1.4e-08 34.7 0.9 9e-08 32.1 0.9 2.5 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus NADHdh PF00146.21 AIF84501.1 - 4.5e-44 151.0 21.3 5.6e-44 150.6 21.3 1.0 1 0 0 1 1 1 1 NADH dehydrogenase Oxidored_q2 PF00420.24 AIF84502.1 - 0.0017 17.9 10.2 0.0017 17.9 10.2 2.9 2 2 0 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Proton_antipo_M PF00361.20 AIF84503.1 - 1.4e-57 195.1 27.5 1.4e-57 195.1 27.5 2.1 2 0 0 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 AIF84503.1 - 5.2e-05 23.2 0.5 5.2e-05 23.2 0.5 3.2 3 0 0 3 3 3 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Complex1_49kDa PF00346.19 AIF84504.1 - 4.8e-35 121.0 0.7 2.5e-29 102.2 0.9 2.3 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Complex1_30kDa PF00329.19 AIF84504.1 - 4.8e-20 72.4 0.0 1.2e-19 71.1 0.0 1.6 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit NiFeSe_Hases PF00374.19 AIF84504.1 - 0.044 12.7 0.3 2.4 7.0 0.1 2.2 2 0 0 2 2 2 0 Nickel-dependent hydrogenase DUF1845 PF08900.11 AIF84504.1 - 0.099 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1845) Vac_Fusion PF02346.16 AIF84504.1 - 0.28 10.8 2.0 28 4.4 0.1 3.8 3 1 1 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 Oxidored_q6 PF01058.22 AIF84505.1 - 1.3e-30 105.9 1.2 3.1e-30 104.7 0.2 1.9 2 0 0 2 2 2 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Fer4_7 PF12838.7 AIF84505.1 - 0.004 17.7 2.2 0.022 15.3 1.3 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIF84505.1 - 0.045 13.9 0.8 0.21 11.7 0.8 2.1 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4 PF00037.27 AIF84505.1 - 0.045 13.6 4.8 0.21 11.5 0.5 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_2 PF12797.7 AIF84505.1 - 0.093 12.9 3.0 3.4 7.9 0.2 2.9 2 0 0 2 2 2 0 4Fe-4S binding domain DUF2175 PF09943.9 AIF84507.1 - 0.074 13.4 0.1 0.26 11.6 0.1 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) CARD PF00619.21 AIF84507.1 - 0.1 12.6 0.2 0.37 10.9 0.1 2.0 2 0 0 2 2 2 0 Caspase recruitment domain AdoHcyase PF05221.17 AIF84508.1 - 1.1e-70 238.2 0.0 1.1e-42 146.2 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 AIF84508.1 - 3.3e-56 189.8 2.5 5.6e-55 185.8 2.1 2.1 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIF84508.1 - 1.6e-10 40.6 1.7 2.3e-10 40.1 0.3 1.9 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 AIF84508.1 - 4.2e-07 29.7 0.3 9.9e-07 28.5 0.3 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 AIF84508.1 - 0.00013 22.0 0.6 0.0037 17.3 0.2 2.3 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase ELFV_dehydrog PF00208.21 AIF84508.1 - 0.004 16.9 0.6 0.0065 16.2 0.6 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.18 AIF84508.1 - 0.028 14.7 0.1 0.084 13.1 0.1 1.9 2 0 0 2 2 2 0 TrkA-N domain XdhC_C PF13478.6 AIF84508.1 - 0.068 13.7 0.1 0.57 10.7 0.1 2.5 3 0 0 3 3 3 0 XdhC Rossmann domain F420_oxidored PF03807.17 AIF84508.1 - 0.099 13.2 0.3 0.27 11.8 0.3 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.21 AIF84508.1 - 0.12 11.6 4.8 0.4 9.9 4.8 1.8 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 AIF84508.1 - 0.28 11.7 1.2 0.66 10.4 1.0 1.8 1 1 0 1 1 1 0 Putative NAD(P)-binding Pribosyltran PF00156.27 AIF84509.1 - 2.2e-26 92.3 0.1 9.8e-26 90.2 0.1 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AIF84509.1 - 3.6e-06 26.6 0.0 4.9e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 AIF84509.1 - 0.0011 18.5 0.0 0.0033 17.0 0.0 1.8 2 0 0 2 2 2 1 Phosphoribosyl transferase LDcluster4 PF18306.1 AIF84510.1 - 4.4e-40 136.8 6.1 5.1e-40 136.6 6.1 1.0 1 0 0 1 1 1 1 SLOG cluster4 family DNA_processg_A PF02481.15 AIF84510.1 - 3.6e-05 23.1 0.5 0.00067 19.0 0.4 2.0 2 0 0 2 2 2 1 DNA recombination-mediator protein A Lysine_decarbox PF03641.14 AIF84510.1 - 0.00016 21.8 1.2 0.00041 20.4 0.0 2.2 1 1 2 3 3 3 1 Possible lysine decarboxylase LSDAT_prok PF18171.1 AIF84510.1 - 0.00017 20.9 0.2 0.00052 19.3 0.0 1.8 2 0 0 2 2 2 1 SLOG in TRPM, prokaryote 3HCDH_N PF02737.18 AIF84511.1 - 1e-65 221.0 0.0 2.8e-65 219.6 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 AIF84511.1 - 4.4e-32 110.6 0.3 5e-25 88.0 0.1 3.2 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_Gly3P_dh_N PF01210.23 AIF84511.1 - 3.5e-06 27.1 0.0 6.4e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 AIF84511.1 - 0.00033 20.9 0.0 0.00063 19.9 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.14 AIF84511.1 - 0.014 15.0 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 AIF84511.1 - 0.022 14.1 0.1 0.04 13.2 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 AIF84511.1 - 0.026 15.1 0.3 0.12 12.9 0.3 2.3 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_2 PF07992.14 AIF84511.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HTH_37 PF13744.6 AIF84511.1 - 0.15 12.0 0.3 0.59 10.1 0.2 2.1 1 1 1 2 2 2 0 Helix-turn-helix domain Ribosomal_L39 PF00832.20 AIF84512.1 - 1.4e-18 66.2 14.3 1.7e-18 65.9 14.3 1.2 1 0 0 1 1 1 1 Ribosomal L39 protein Ribosomal_L31e PF01198.19 AIF84513.1 - 2.3e-18 66.2 0.8 3.5e-18 65.6 0.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L31e Ribosomal_60s PF00428.19 AIF84513.1 - 0.12 13.0 9.0 0.19 12.3 9.0 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein Podoplanin PF05808.11 AIF84513.1 - 0.19 11.8 1.3 0.24 11.5 1.3 1.2 1 0 0 1 1 1 0 Podoplanin TMEM171 PF15471.6 AIF84513.1 - 0.21 10.5 0.2 0.29 10.1 0.2 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 DUF983 PF06170.12 AIF84515.1 - 0.034 14.5 0.2 0.034 14.5 0.2 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF983) zf-trcl PF13451.6 AIF84515.1 - 0.057 13.3 0.3 0.057 13.3 0.3 3.1 3 0 0 3 3 3 0 Probable zinc-ribbon domain DUF2175 PF09943.9 AIF84515.1 - 0.079 13.3 1.0 0.079 13.3 1.0 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Tubulin PF00091.25 AIF84516.1 - 2.7e-14 53.8 0.2 7.2e-13 49.2 0.2 2.2 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Pribosyltran PF00156.27 AIF84516.1 - 0.026 14.0 0.0 0.058 12.9 0.0 1.6 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Radical_SAM PF04055.21 AIF84517.1 - 6.1e-23 82.0 0.0 1e-22 81.3 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.20 AIF84517.1 - 9.4e-18 64.1 0.5 2e-17 63.0 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 PEP-utilisers_N PF05524.13 AIF84521.1 - 0.15 12.2 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal AhpC-TSA PF00578.21 AIF84522.1 - 1.3e-23 83.3 0.0 1.6e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIF84522.1 - 5.9e-18 65.0 0.0 7.1e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Redoxin GSHPx PF00255.19 AIF84522.1 - 1.2e-06 28.0 0.0 1.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin_2 PF13098.6 AIF84522.1 - 0.0029 18.0 0.0 0.0058 17.1 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain SCO1-SenC PF02630.14 AIF84522.1 - 0.034 14.1 0.0 0.048 13.6 0.0 1.2 1 0 0 1 1 1 0 SCO1/SenC Thioredoxin_8 PF13905.6 AIF84522.1 - 0.1 12.9 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like DAO PF01266.24 AIF84523.1 - 4.1e-07 29.9 6.4 0.0016 18.1 2.0 2.4 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 AIF84523.1 - 1.4e-05 24.5 1.9 5.8e-05 22.5 1.9 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AIF84523.1 - 8.7e-05 21.4 5.4 0.00019 20.3 2.2 2.2 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 AIF84523.1 - 0.00014 21.2 1.6 0.17 11.1 1.2 3.1 3 0 0 3 3 3 2 FAD binding domain FAD_binding_2 PF00890.24 AIF84523.1 - 0.00055 19.1 1.2 0.0012 18.0 1.2 1.7 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 AIF84523.1 - 0.00084 18.8 1.0 0.00084 18.8 1.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 AIF84523.1 - 0.0021 17.3 0.2 0.0039 16.5 0.2 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 AIF84523.1 - 0.0054 16.9 1.9 0.0077 16.4 0.5 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain ETF_QO PF05187.13 AIF84523.1 - 0.012 15.8 0.4 0.065 13.4 0.4 2.2 2 0 0 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S GIDA PF01134.22 AIF84523.1 - 0.02 14.0 0.5 0.051 12.7 0.5 1.7 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 AIF84523.1 - 0.039 13.0 0.7 0.082 11.9 0.7 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 AIF84523.1 - 0.15 11.4 1.0 0.38 10.0 0.7 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 AIF84523.1 - 0.16 12.5 0.4 0.55 10.8 0.4 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 AIF84523.1 - 0.24 11.4 0.9 1.8 8.5 0.7 2.5 2 1 0 2 2 2 0 FAD-NAD(P)-binding Fer4 PF00037.27 AIF84523.1 - 1.1 9.2 4.5 0.3 11.0 1.2 1.8 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_alpha PF00766.19 AIF84524.1 - 1.9e-25 88.7 0.1 5.3e-25 87.3 0.0 1.8 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.21 AIF84524.1 - 8.1e-17 61.7 0.0 5.3e-16 59.0 0.0 2.0 1 1 0 1 1 1 1 Electron transfer flavoprotein domain ETF PF01012.21 AIF84525.1 - 7.3e-26 91.2 0.1 1e-25 90.7 0.1 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain HD_4 PF13328.6 AIF84526.1 - 5.3e-11 42.5 0.0 8.8e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 HD domain T3SS_needle_E PF08988.10 AIF84526.1 - 0.12 12.5 0.3 3.9 7.7 0.3 2.4 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle MannoseP_isomer PF01050.18 AIF84527.1 - 2.4e-20 73.0 0.0 2.6e-20 72.8 0.0 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.11 AIF84527.1 - 2.5e-08 33.5 0.0 4e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Pirin_C_2 PF17954.1 AIF84527.1 - 0.021 15.0 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 Quercetinase C-terminal cupin domain Ppnp PF06865.11 AIF84527.1 - 0.028 14.9 0.0 0.038 14.4 0.0 1.2 1 0 0 1 1 1 0 Pyrimidine/purine nucleoside phosphorylase Alginate_exp PF13372.6 AIF84527.1 - 0.063 12.0 0.0 0.069 11.9 0.0 1.1 1 0 0 1 1 1 0 Alginate export CENP-C_C PF11699.8 AIF84527.1 - 0.07 13.4 0.0 0.084 13.1 0.0 1.2 1 0 0 1 1 1 0 Mif2/CENP-C like AraC_binding PF02311.19 AIF84527.1 - 0.15 11.9 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 AraC-like ligand binding domain A2L_zn_ribbon PF08792.10 AIF84528.1 - 0.39 10.5 3.0 2.1 8.2 0.2 2.7 3 0 0 3 3 3 0 A2L zinc ribbon domain HTH_20 PF12840.7 AIF84529.1 - 5.1e-16 58.5 0.2 1.5e-15 57.0 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_5 PF01022.20 AIF84529.1 - 3.6e-12 45.9 0.1 9.6e-12 44.6 0.0 1.7 2 0 0 2 2 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 AIF84529.1 - 2.4e-09 36.6 0.0 6.7e-09 35.2 0.0 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 AIF84529.1 - 9e-08 31.9 0.0 2.5e-07 30.5 0.0 1.8 2 0 0 2 2 1 1 MarR family HTH_Crp_2 PF13545.6 AIF84529.1 - 1.1e-05 25.3 0.0 2.4e-05 24.2 0.1 1.6 1 1 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_11 PF08279.12 AIF84529.1 - 2.1e-05 24.3 0.0 6.7e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 HTH domain HTH_34 PF13601.6 AIF84529.1 - 0.0016 18.6 0.1 0.003 17.7 0.1 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.22 AIF84529.1 - 0.0036 17.2 0.0 0.0081 16.1 0.0 1.6 1 0 0 1 1 1 1 MarR family HTH_12 PF08461.10 AIF84529.1 - 0.0051 16.7 0.0 0.0098 15.8 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain B-block_TFIIIC PF04182.12 AIF84529.1 - 0.013 15.6 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC Sigma70_r4 PF04545.16 AIF84529.1 - 0.019 14.5 0.0 0.085 12.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_27 PF13463.6 AIF84529.1 - 0.033 14.7 0.0 0.068 13.7 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain FaeA PF04703.12 AIF84529.1 - 0.042 14.2 0.0 0.087 13.2 0.0 1.6 1 0 0 1 1 1 0 FaeA-like protein HTH_IclR PF09339.10 AIF84529.1 - 0.057 13.2 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF2513 PF10711.9 AIF84529.1 - 0.064 13.5 0.0 0.15 12.3 0.0 1.6 2 0 0 2 2 2 0 Hypothetical protein (DUF2513) DprA_WH PF17782.1 AIF84529.1 - 0.065 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 DprA winged helix domain HTH_10 PF04967.12 AIF84529.1 - 0.068 13.0 0.0 0.26 11.1 0.0 2.0 2 0 0 2 2 2 0 HTH DNA binding domain Sigma70_r4_2 PF08281.12 AIF84529.1 - 0.089 12.5 0.0 0.32 10.7 0.0 1.9 2 0 0 2 2 1 0 Sigma-70, region 4 TrmB PF01978.19 AIF84529.1 - 0.099 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Rrf2 PF02082.20 AIF84529.1 - 0.11 12.9 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator TIM21 PF08294.11 AIF84529.1 - 0.14 12.1 0.0 7.9 6.3 0.0 2.3 2 0 0 2 2 2 0 TIM21 Asn_synthase PF00733.21 AIF84530.1 - 1.7e-51 175.9 2.6 1.8e-32 113.4 0.0 2.2 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 AIF84530.1 - 3.3e-34 117.5 0.0 5.5e-34 116.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 AIF84530.1 - 1.1e-33 116.2 0.1 2.3e-33 115.2 0.1 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain NAD_synthase PF02540.17 AIF84530.1 - 0.001 18.2 0.0 0.0096 15.1 0.1 2.1 2 0 0 2 2 2 1 NAD synthase QueC PF06508.13 AIF84530.1 - 0.0031 17.1 0.0 0.0066 16.0 0.0 1.6 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 AIF84530.1 - 0.047 13.7 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family HypA PF01155.19 AIF84531.1 - 0.00023 21.2 0.3 0.00023 21.1 0.3 1.0 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_1 PF00130.22 AIF84531.1 - 0.0023 17.8 1.2 0.0028 17.5 1.2 1.1 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) VATC PF18716.1 AIF84531.1 - 0.022 14.6 1.5 4.6 7.2 0.2 2.1 2 0 0 2 2 2 0 Vms1-associating treble clef domain Spt4 PF06093.13 AIF84531.1 - 0.036 14.2 0.9 0.038 14.1 0.9 1.1 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger PSCyt3 PF07627.11 AIF84531.1 - 0.04 14.2 0.3 0.047 14.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) Fumerase_C PF05683.12 AIF84531.1 - 0.1 11.9 0.0 0.1 11.9 0.0 1.0 1 0 0 1 1 1 0 Fumarase C-terminus UvrB_inter PF17757.1 AIF84532.1 - 5.6e-27 93.7 0.2 1.8e-26 92.1 0.0 2.0 2 0 0 2 2 2 1 UvrB interaction domain UvrB PF12344.8 AIF84532.1 - 7.4e-21 73.7 2.0 2.2e-20 72.2 2.0 1.9 1 0 0 1 1 1 1 Ultra-violet resistance protein B Helicase_C PF00271.31 AIF84532.1 - 1.1e-18 67.6 0.2 3.1e-18 66.1 0.2 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AIF84532.1 - 2.4e-10 40.7 0.1 1.6e-09 38.0 0.1 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AIF84532.1 - 3.6e-06 26.9 0.1 0.00041 20.1 0.0 3.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase UVR PF02151.19 AIF84532.1 - 0.0077 16.0 7.0 0.0077 16.0 7.0 2.8 3 0 0 3 3 2 1 UvrB/uvrC motif AAA_30 PF13604.6 AIF84532.1 - 0.0089 15.8 0.0 0.076 12.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain Tim44 PF04280.15 AIF84532.1 - 0.026 14.6 1.6 0.14 12.3 0.1 2.4 2 0 0 2 2 2 0 Tim44-like domain Kinesin PF00225.23 AIF84532.1 - 0.026 13.5 0.1 0.052 12.5 0.1 1.4 1 0 0 1 1 1 0 Kinesin motor domain Microtub_bd PF16796.5 AIF84532.1 - 0.057 13.4 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 Microtubule binding UB2H PF14814.6 AIF84532.1 - 0.1 12.7 0.0 1.1 9.3 0.0 2.6 2 0 0 2 2 2 0 Bifunctional transglycosylase second domain AAA_33 PF13671.6 AIF84532.1 - 0.11 12.7 0.2 0.57 10.3 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 AIF84532.1 - 0.13 11.8 0.0 0.31 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP-synt_ab PF00006.25 AIF84532.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.5 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_22 PF13401.6 AIF84532.1 - 0.24 11.7 1.3 3.8 7.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 AIF84532.1 - 0.36 11.1 5.6 3.2 8.1 0.4 2.8 2 1 0 2 2 2 0 AAA domain UvrA_DNA-bind PF17755.1 AIF84533.1 - 4.1e-37 126.9 0.1 1.5e-34 118.6 0.1 3.3 3 0 0 3 3 3 1 UvrA DNA-binding domain UvrA_inter PF17760.1 AIF84533.1 - 1e-35 122.1 0.2 2.5e-35 120.8 0.2 1.7 1 0 0 1 1 1 1 UvrA interaction domain ABC_tran PF00005.27 AIF84533.1 - 3e-22 79.6 0.6 0.00024 21.6 0.0 4.6 4 0 0 4 4 4 4 ABC transporter SMC_N PF02463.19 AIF84533.1 - 1e-10 41.4 0.5 0.23 10.9 0.0 4.2 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 AIF84533.1 - 2.7e-08 34.0 7.4 0.001 18.9 0.0 4.4 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 AIF84533.1 - 3.7e-08 33.9 0.0 0.033 14.6 0.0 3.7 4 0 0 4 4 4 2 AAA ATPase domain AAA_29 PF13555.6 AIF84533.1 - 5.4e-08 32.5 0.2 0.016 14.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AIF84533.1 - 4.3e-07 30.0 0.0 0.013 15.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_25 PF13481.6 AIF84533.1 - 3.8e-06 26.6 0.0 0.092 12.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 AIF84533.1 - 7e-06 26.3 0.3 0.27 11.4 0.0 3.9 4 0 0 4 4 4 2 AAA domain AAA_23 PF13476.6 AIF84533.1 - 1.5e-05 25.6 7.1 0.0011 19.5 0.4 3.0 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 AIF84533.1 - 7.9e-05 22.7 0.0 0.22 11.6 0.0 3.5 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 AIF84533.1 - 8.7e-05 22.5 0.0 0.14 12.1 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.6 AIF84533.1 - 0.00014 22.2 2.5 0.58 10.4 0.0 3.8 5 0 0 5 5 4 2 AAA domain APS_kinase PF01583.20 AIF84533.1 - 0.00034 20.6 0.8 0.37 10.7 0.0 3.1 3 0 0 3 3 3 1 Adenylylsulphate kinase AAA_18 PF13238.6 AIF84533.1 - 0.0004 20.9 0.9 1 9.9 0.0 3.1 3 0 0 3 3 2 2 AAA domain cobW PF02492.19 AIF84533.1 - 0.00042 20.0 0.1 0.21 11.1 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DUF2075 PF09848.9 AIF84533.1 - 0.00084 18.7 0.1 0.91 8.7 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 AIF84533.1 - 0.0013 17.9 0.1 1.1 8.3 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein ATPase PF06745.13 AIF84533.1 - 0.0016 17.8 0.1 0.84 8.9 0.0 2.7 2 0 0 2 2 2 1 KaiC NB-ARC PF00931.22 AIF84533.1 - 0.0021 17.3 0.5 4.7 6.3 0.1 3.4 3 0 0 3 3 3 0 NB-ARC domain Viral_helicase1 PF01443.18 AIF84533.1 - 0.0022 17.8 0.0 0.27 10.9 0.1 2.8 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 AIF84533.1 - 0.0038 17.2 0.4 1.4 8.8 0.0 3.0 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea DnaJ_CXXCXGXG PF00684.19 AIF84533.1 - 0.0065 16.8 14.3 0.018 15.4 0.9 4.2 3 1 0 3 3 3 1 DnaJ central domain MMR_HSR1 PF01926.23 AIF84533.1 - 0.0078 16.3 0.3 4.7 7.3 0.0 3.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_30 PF13604.6 AIF84533.1 - 0.012 15.4 0.1 7.2 6.3 0.1 2.7 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 AIF84533.1 - 0.015 15.2 1.9 3.5 7.5 0.1 3.3 3 0 0 3 3 2 0 NTPase RNA_helicase PF00910.22 AIF84533.1 - 0.016 15.6 0.0 2.8 8.4 0.0 2.7 2 0 0 2 2 2 0 RNA helicase MeaB PF03308.16 AIF84533.1 - 0.018 14.0 0.3 5.5 5.9 0.1 2.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 AIF84533.1 - 0.03 14.6 0.3 13 6.0 0.0 3.2 4 0 0 4 4 2 0 AAA domain AAA_15 PF13175.6 AIF84533.1 - 0.033 13.9 10.4 1.9 8.1 0.0 4.4 5 0 0 5 5 5 0 AAA ATPase domain RACo_linker PF17650.1 AIF84533.1 - 0.05 13.5 0.0 1.1 9.2 0.0 2.9 3 0 0 3 3 2 0 RACo linker region AAA_24 PF13479.6 AIF84533.1 - 0.058 13.1 1.4 14 5.3 0.1 3.1 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 AIF84533.1 - 0.066 12.7 0.4 26 4.3 0.1 3.2 3 0 0 3 3 3 0 P-loop containing dynein motor region BCA_ABC_TP_C PF12399.8 AIF84533.1 - 0.072 13.0 0.1 0.22 11.5 0.1 1.9 1 0 0 1 1 1 0 Branched-chain amino acid ATP-binding cassette transporter Sigma54_activat PF00158.26 AIF84533.1 - 0.076 12.7 0.2 2.1 8.0 0.0 2.7 3 0 0 3 3 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 AIF84533.1 - 0.086 12.1 0.0 3.7 6.8 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin FtsK_SpoIIIE PF01580.18 AIF84533.1 - 0.11 11.8 0.5 4.9 6.4 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family DAP3 PF10236.9 AIF84533.1 - 0.13 11.4 0.2 13 4.8 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF4756 PF15948.5 AIF84533.1 - 0.72 9.7 2.5 1 9.2 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4756) zf-FPG_IleRS PF06827.14 AIF84533.1 - 0.9 9.5 9.4 2.8 7.9 0.2 3.6 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS DUF87 PF01935.17 AIF84533.1 - 1.6 8.8 5.1 8.3 6.4 0.1 3.6 4 0 0 4 4 4 0 Helicase HerA, central domain UvrC_HhH_N PF08459.11 AIF84534.1 - 1.7e-40 138.4 0.0 4e-40 137.2 0.0 1.6 1 0 0 1 1 1 1 UvrC Helix-hairpin-helix N-terminal GIY-YIG PF01541.24 AIF84534.1 - 5e-12 45.9 1.0 1.4e-11 44.5 0.1 2.2 2 0 0 2 2 2 1 GIY-YIG catalytic domain UVR PF02151.19 AIF84534.1 - 2e-06 27.3 2.4 2e-06 27.3 2.4 1.9 2 0 0 2 2 2 1 UvrB/uvrC motif RE_Eco29kI PF09517.10 AIF84534.1 - 0.069 12.8 0.1 0.96 9.0 0.1 2.3 1 1 0 1 1 1 0 Eco29kI restriction endonuclease DUF294 PF03445.13 AIF84535.1 - 0.073 12.9 0.2 0.085 12.7 0.2 1.1 1 0 0 1 1 1 0 Putative nucleotidyltransferase DUF294 AlaDh_PNT_N PF05222.15 AIF84537.1 - 4.9e-38 130.5 0.1 8.6e-38 129.7 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 AIF84537.1 - 6.8e-21 74.6 1.3 2.1e-20 73.0 0.9 2.0 2 1 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 AIF84537.1 - 2e-05 23.5 0.4 3e-05 22.9 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_7 PF13241.6 AIF84537.1 - 8e-05 23.0 0.1 0.0002 21.7 0.1 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 AIF84537.1 - 0.0019 17.5 0.1 0.0038 16.5 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Shikimate_DH PF01488.20 AIF84537.1 - 0.0031 17.6 0.2 0.0078 16.3 0.2 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 AIF84537.1 - 0.014 14.8 0.4 0.028 13.8 0.1 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 AIF84537.1 - 0.016 14.5 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AIF84537.1 - 0.025 13.9 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 AIF84537.1 - 0.032 14.8 0.0 0.13 12.8 0.0 2.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AIF84537.1 - 0.032 13.3 0.2 0.081 12.0 0.1 1.7 2 0 0 2 2 2 0 FAD binding domain Copper-bind PF00127.20 AIF84538.1 - 1.5e-10 41.4 0.4 2e-10 41.0 0.4 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF84538.1 - 1.9e-05 24.7 0.2 5.5e-05 23.2 0.2 1.8 1 1 0 1 1 1 1 Cupredoxin-like domain DUF2175 PF09943.9 AIF84538.1 - 0.2 12.0 0.2 0.38 11.1 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Ac110_PIF PF07280.11 AIF84538.1 - 3.1 7.7 5.2 16 5.4 1.6 2.4 2 1 0 2 2 2 0 Per os infectivity factor AC110 DUF4367 PF14285.6 AIF84539.1 - 0.00081 19.8 0.3 0.0022 18.4 0.2 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4367) NUMOD1 PF07453.13 AIF84539.1 - 0.15 12.4 1.4 0.3 11.4 1.4 1.5 1 0 0 1 1 1 0 NUMOD1 domain Cupredoxin_1 PF13473.6 AIF84540.1 - 3.1e-11 43.3 0.0 4.1e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 AIF84540.1 - 3.4e-10 40.2 0.5 1.4e-09 38.3 0.5 1.9 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family HTH_45 PF14947.6 AIF84541.1 - 1.7e-06 27.9 0.1 2e-06 27.7 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIF84541.1 - 0.0039 17.1 0.0 0.0063 16.4 0.0 1.2 1 0 0 1 1 1 1 MarR family DUF2680 PF10925.8 AIF84541.1 - 0.0079 16.2 0.2 0.57 10.2 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2680) DUF1495 PF07381.11 AIF84541.1 - 0.05 13.4 0.0 0.15 11.9 0.0 1.6 1 1 1 2 2 2 0 Winged helix DNA-binding domain (DUF1495) Tudor_FRX1 PF18336.1 AIF84541.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Fragile X mental retardation Tudor domain DUF2207 PF09972.9 AIF84542.1 - 0.0012 17.7 0.1 0.0012 17.7 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF2721 PF11026.8 AIF84542.1 - 0.0039 17.1 0.6 0.023 14.6 0.1 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF2721) Wzz PF02706.15 AIF84542.1 - 0.014 15.7 0.4 1.9 8.8 0.0 2.1 2 0 0 2 2 2 0 Chain length determinant protein DUF4231 PF14015.6 AIF84542.1 - 0.11 13.0 0.8 0.15 12.6 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Brr6_like_C_C PF10104.9 AIF84542.1 - 0.34 10.7 2.8 0.55 10.0 0.3 2.2 2 1 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain DUF2852 PF11014.8 AIF84542.1 - 0.96 9.6 5.1 32 4.7 5.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2852) PrgI PF12666.7 AIF84542.1 - 3.9 8.3 7.1 8.3 7.2 7.1 1.5 1 1 0 1 1 1 0 PrgI family protein DUF998 PF06197.13 AIF84543.1 - 0.001 18.7 2.8 0.001 18.7 2.8 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF998) Tetraspanin PF00335.20 AIF84543.1 - 0.72 9.5 3.9 0.15 11.7 0.8 1.4 2 0 0 2 2 2 0 Tetraspanin family SnoaL_2 PF12680.7 AIF84544.1 - 0.045 14.4 3.0 0.54 10.9 3.0 2.0 1 1 0 1 1 1 0 SnoaL-like domain NitrOD2 PF18550.1 AIF84545.1 - 1.4e-30 105.5 0.2 1.6e-30 105.3 0.2 1.0 1 0 0 1 1 1 1 Nitrososphaera output domain 2 CcdA PF07362.12 AIF84547.1 - 0.018 15.4 0.3 0.15 12.5 0.3 2.0 1 1 0 1 1 1 0 Post-segregation antitoxin CcdA RPN1_C PF18051.1 AIF84547.1 - 0.11 12.6 0.0 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal DUF2228 PF10228.9 AIF84547.1 - 0.12 12.1 0.0 0.12 12.1 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) NitrOD2 PF18550.1 AIF84548.1 - 5.2e-34 116.5 0.0 6.6e-34 116.2 0.0 1.0 1 0 0 1 1 1 1 Nitrososphaera output domain 2 DNA_alkylation PF08713.11 AIF84548.1 - 0.055 13.2 0.0 0.077 12.7 0.0 1.2 1 0 0 1 1 1 0 DNA alkylation repair enzyme zf-Di19 PF05605.12 AIF84549.1 - 0.00041 20.6 1.4 0.02 15.2 0.1 3.1 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-DNA_Pol PF08996.10 AIF84549.1 - 0.029 14.1 0.2 0.066 13.0 0.2 1.7 1 1 0 1 1 1 0 DNA Polymerase alpha zinc finger PyrI_C PF02748.15 AIF84549.1 - 1.5 8.8 6.5 8.1 6.4 0.2 3.0 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_4 PF13894.6 AIF84549.1 - 4.6 8.3 8.1 17 6.6 0.1 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger Radical_SAM PF04055.21 AIF84551.1 - 5.6e-15 56.1 0.0 1e-14 55.3 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 AIF84551.1 - 0.086 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain Radical_SAM PF04055.21 AIF84552.1 - 4.2e-11 43.5 0.0 8.3e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Trypsin_2 PF13365.6 AIF84553.1 - 1.6e-33 116.7 0.1 3.3e-33 115.7 0.1 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 AIF84553.1 - 5.4e-15 55.5 8.1 4e-12 46.3 5.4 3.3 2 1 0 2 2 2 1 PDZ domain Trypsin PF00089.26 AIF84553.1 - 1.4e-12 47.9 0.0 2.7e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 AIF84553.1 - 2.1e-08 33.9 7.5 5.4e-06 26.2 0.3 3.0 3 1 1 4 4 4 2 PDZ domain PDZ PF00595.24 AIF84553.1 - 9.8e-06 25.8 1.3 0.00089 19.6 0.0 3.4 3 0 0 3 3 3 1 PDZ domain Peptidase_S29 PF02907.15 AIF84553.1 - 0.01 15.6 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Tricorn_PDZ PF14685.6 AIF84553.1 - 0.053 13.5 1.4 6.9 6.7 0.1 3.1 2 1 1 3 3 3 0 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 AIF84553.1 - 0.19 10.4 0.6 0.27 9.8 0.1 1.4 2 0 0 2 2 2 0 Peptidase S46 HTH_45 PF14947.6 AIF84554.1 - 4.8e-18 64.9 0.1 5.8e-18 64.6 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIF84554.1 - 2.8e-05 23.9 0.1 3.5e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_27 PF13463.6 AIF84554.1 - 0.00052 20.5 0.1 0.00082 19.8 0.1 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_IclR PF09339.10 AIF84554.1 - 0.074 12.9 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF1495 PF07381.11 AIF84554.1 - 0.095 12.5 0.1 0.19 11.6 0.0 1.5 1 1 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) Glycos_transf_2 PF00535.26 AIF84555.1 - 4.5e-30 104.7 0.0 6.5e-30 104.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIF84555.1 - 1.9e-21 77.0 0.0 2.6e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 AIF84555.1 - 6.6e-13 48.5 0.0 1.1e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 AIF84555.1 - 1.8e-09 37.5 0.0 2.5e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AIF84555.1 - 0.00013 22.4 0.0 0.00023 21.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Polyketide_cyc2 PF10604.9 AIF84556.1 - 4.7e-12 46.4 0.1 5.1e-12 46.3 0.1 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIF84556.1 - 6.4e-09 36.1 0.0 9.6e-09 35.5 0.0 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.13 AIF84556.1 - 0.01 15.6 0.1 0.013 15.2 0.1 1.2 1 0 0 1 1 1 1 Carbon monoxide dehydrogenase subunit G (CoxG) GLEYA PF10528.9 AIF84556.1 - 0.026 14.9 0.0 0.038 14.4 0.0 1.3 1 0 0 1 1 1 0 GLEYA domain DUF2505 PF10698.9 AIF84556.1 - 0.055 13.6 0.3 3.9 7.6 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2505) CbtA PF09490.10 AIF84557.1 - 5e-50 170.5 20.0 5.7e-50 170.3 20.0 1.0 1 0 0 1 1 1 1 Probable cobalt transporter subunit (CbtA) 7tm_3 PF00003.22 AIF84557.1 - 0.077 12.7 4.3 0.041 13.6 0.8 2.1 1 1 1 2 2 2 0 7 transmembrane sweet-taste receptor of 3 GCPR Acyl_transf_3 PF01757.22 AIF84557.1 - 0.75 8.8 10.1 2.7 7.0 4.0 2.2 1 1 1 2 2 2 0 Acyltransferase family 7TM-7TMR_HD PF07698.11 AIF84557.1 - 3.1 7.5 13.7 0.11 12.2 1.7 3.0 2 1 1 3 3 3 0 7TM receptor with intracellular HD hydrolase DUF1427 PF07235.11 AIF84557.1 - 3.7 7.6 10.5 4.1 7.4 1.1 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1427) CbtB PF09489.10 AIF84558.1 - 1.2e-13 50.9 0.5 1.6e-13 50.5 0.5 1.2 1 0 0 1 1 1 1 Probable cobalt transporter subunit (CbtB) DUF4443 PF14544.6 AIF84559.1 - 1.4e-05 25.3 0.0 2.3e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4443) HTH_24 PF13412.6 AIF84559.1 - 0.043 13.4 0.2 0.15 11.6 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Thi4 PF01946.17 AIF84559.1 - 0.058 12.6 0.1 0.12 11.6 0.0 1.5 2 0 0 2 2 2 0 Thi4 family HTH_45 PF14947.6 AIF84559.1 - 0.059 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix FeoC PF09012.10 AIF84559.1 - 0.07 13.2 0.2 0.15 12.1 0.2 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator Yae1_N PF09811.9 AIF84560.1 - 0.3 10.8 6.6 8.3 6.2 0.9 3.0 2 1 0 2 2 2 0 Essential protein Yae1, N terminal Guanylate_cyc PF00211.20 AIF84562.1 - 1.3e-14 54.2 0.0 1.8e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain CBS PF00571.28 AIF84563.1 - 2.5e-24 85.5 1.4 1.1e-13 51.4 0.0 2.1 2 0 0 2 2 2 2 CBS domain Methyltransf_31 PF13847.6 AIF84563.1 - 0.14 12.0 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Usp PF00582.26 AIF84564.1 - 9.2e-30 104.0 0.4 1.1e-29 103.7 0.4 1.1 1 0 0 1 1 1 1 Universal stress protein family RDD PF06271.12 AIF84565.1 - 4.7e-18 65.8 5.0 6e-18 65.4 5.0 1.1 1 0 0 1 1 1 1 RDD family HTH_27 PF13463.6 AIF84566.1 - 0.0012 19.3 0.6 0.011 16.2 0.2 2.1 2 0 0 2 2 2 1 Winged helix DNA-binding domain Dynactin_p22 PF07426.11 AIF84566.1 - 0.11 12.4 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Dynactin subunit p22 Trimer_CC PF08954.11 AIF84566.1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Trimerisation motif Nramp PF01566.18 AIF84569.1 - 7.2e-79 265.4 19.5 8.8e-79 265.1 19.5 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein CoatB PF10389.9 AIF84573.1 - 0.37 10.7 3.4 0.64 9.9 3.4 1.3 1 0 0 1 1 1 0 Bacteriophage coat protein B SbsC_C PF18058.1 AIF84574.1 - 0.0052 17.0 0.2 0.0094 16.2 0.2 1.4 1 0 0 1 1 1 1 SbsC C-terminal domain Phage_RpbA PF10789.9 AIF84574.1 - 0.016 15.2 0.9 5.1 7.2 0.1 2.3 2 0 0 2 2 2 0 Phage RNA polymerase binding, RpbA Vps8 PF12816.7 AIF84574.1 - 0.019 14.5 0.9 0.029 13.9 0.9 1.2 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 RseA_C PF03873.13 AIF84574.1 - 0.11 12.8 1.6 0.4 11.0 1.6 1.9 1 0 0 1 1 1 0 Anti sigma-E protein RseA, C-terminal domain TENA_THI-4 PF03070.16 AIF84575.1 - 1.9e-14 54.0 0.4 2.4e-14 53.6 0.4 1.1 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Haem_oxygenas_2 PF14518.6 AIF84575.1 - 6.2e-13 48.9 0.1 7.9e-13 48.6 0.1 1.1 1 0 0 1 1 1 1 Iron-containing redox enzyme PH_8 PF15409.6 AIF84575.1 - 0.09 13.1 0.0 8.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain Phage_integr_3 PF16795.5 AIF84576.1 - 1.4e-09 38.0 0.4 2.4e-09 37.3 0.4 1.3 1 0 0 1 1 1 1 Archaeal phage integrase IGPS PF00218.21 AIF84578.1 - 0.05 12.8 0.1 0.05 12.8 0.1 1.0 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase Gram_pos_anchor PF00746.21 AIF84582.1 - 0.55 10.2 6.0 0.49 10.4 0.4 2.6 2 0 0 2 2 2 0 LPXTG cell wall anchor motif HEPN PF05168.14 AIF84583.1 - 1.1e-07 32.0 2.1 1.8e-07 31.3 1.0 2.0 2 1 0 2 2 2 1 HEPN domain HEPN_AbiV PF18728.1 AIF84583.1 - 0.026 14.7 9.5 0.067 13.4 9.5 1.6 1 1 0 1 1 1 0 AbiV Cutinase PF01083.22 AIF84583.1 - 0.032 14.2 0.0 8.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Cutinase MCM PF00493.23 AIF84584.1 - 7.9e-42 142.9 0.0 1.3e-41 142.2 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 AIF84584.1 - 4.8e-15 55.8 1.4 7.6e-15 55.1 0.5 1.9 2 0 0 2 2 2 1 MCM AAA-lid domain AAA_5 PF07728.14 AIF84584.1 - 3.1e-06 27.2 0.0 7.5e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 AIF84584.1 - 3.3e-06 26.7 0.0 0.059 12.7 0.1 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI MCM_OB PF17207.3 AIF84584.1 - 2.4e-05 24.2 1.2 5.3e-05 23.1 0.2 2.1 2 0 0 2 2 2 1 MCM OB domain AAA_3 PF07726.11 AIF84584.1 - 0.00023 21.0 0.0 0.00049 20.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AIF84584.1 - 0.00068 19.4 0.0 0.011 15.5 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain KRAB PF01352.27 AIF84587.1 - 0.048 13.3 0.0 0.095 12.4 0.0 1.5 1 0 0 1 1 1 0 KRAB box DUF1542 PF07564.11 AIF84589.1 - 0.013 15.6 0.9 0.013 15.6 0.9 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) Helicase_C_3 PF13625.6 AIF84589.1 - 0.037 14.2 0.0 0.2 11.8 0.0 1.8 1 1 1 2 2 2 0 Helicase conserved C-terminal domain TBPIP PF07106.13 AIF84589.1 - 0.07 13.1 0.0 0.23 11.4 0.0 1.9 1 1 0 1 1 1 0 TBPIP/Hop2 winged helix domain Pro_sub2 PF18513.1 AIF84589.1 - 0.08 13.1 0.5 0.29 11.3 0.2 1.8 1 1 1 2 2 2 0 Prodomain subtilisin 2 polyprenyl_synt PF00348.17 AIF84595.1 - 4.4e-52 176.7 0.0 6e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Proton_antipo_M PF00361.20 AIF84596.1 - 2e-67 227.5 22.7 2e-67 227.5 22.7 2.3 1 1 1 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_M PF00361.20 AIF84597.1 - 2.1e-65 220.8 30.9 1.9e-58 198.0 30.1 2.6 2 0 0 2 2 2 2 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 AIF84597.1 - 1.1e-11 44.6 2.2 1.1e-11 44.6 2.2 2.8 2 0 0 2 2 2 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Proton_antipo_C PF01010.19 AIF84597.1 - 0.0017 18.1 0.0 0.0029 17.3 0.0 1.3 1 0 0 1 1 1 1 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus Proton_antipo_M PF00361.20 AIF84598.1 - 7.3e-65 219.1 28.1 7.3e-65 219.1 28.1 1.7 1 1 0 1 1 1 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 AIF84598.1 - 0.0018 18.3 0.0 0.0018 18.3 0.0 3.5 3 0 0 3 3 3 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Oxidored_q2 PF00420.24 AIF84599.1 - 4.6e-25 87.3 7.8 5.4e-25 87.0 7.8 1.0 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Proton_antipo_C PF01010.19 AIF84599.1 - 0.17 11.5 2.2 0.19 11.3 2.2 1.0 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus DUF3098 PF11297.8 AIF84599.1 - 1.2 8.8 9.4 0.25 11.0 3.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3098) DUF4418 PF14387.6 AIF84599.1 - 5.1 7.3 10.6 0.88 9.8 4.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4418) Oxidored_q3 PF00499.20 AIF84600.1 - 1.2e-23 83.4 19.1 1.5e-23 83.1 19.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF4040 PF13244.6 AIF84600.1 - 0.0012 18.9 13.6 0.0012 18.9 13.6 2.5 3 1 0 3 3 3 1 Domain of unknown function (DUF4040) Fer4 PF00037.27 AIF84601.1 - 4.3e-13 48.5 11.0 3.4e-09 36.1 1.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 AIF84601.1 - 7.6e-10 38.8 17.7 2.4e-06 27.5 11.0 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 AIF84601.1 - 2.2e-09 37.8 6.3 3.9e-09 36.9 6.3 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIF84601.1 - 4.2e-07 29.8 11.9 4.4e-05 23.4 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 AIF84601.1 - 5.9e-07 29.5 10.0 1.5e-06 28.2 10.1 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIF84601.1 - 7e-07 29.6 1.7 0.003 18.0 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 AIF84601.1 - 1.2e-06 28.6 8.6 4.7e-06 26.7 9.3 1.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 AIF84601.1 - 2.4e-06 27.6 7.5 0.012 16.1 0.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 AIF84601.1 - 1.5e-05 24.8 10.9 0.0016 18.4 1.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 AIF84601.1 - 0.00014 22.5 3.9 0.1 13.3 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_16 PF13484.6 AIF84601.1 - 0.00085 20.2 10.3 0.0088 17.0 0.3 2.3 1 1 2 3 3 3 2 4Fe-4S double cluster binding domain Fer4_17 PF13534.6 AIF84601.1 - 0.0011 19.4 9.8 0.051 14.1 0.6 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_13 PF13370.6 AIF84601.1 - 0.0021 18.5 4.5 0.23 12.0 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 AIF84601.1 - 0.011 16.6 4.1 0.011 16.6 4.1 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 AIF84601.1 - 0.11 12.8 10.4 0.36 11.0 1.7 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_22 PF17179.4 AIF84601.1 - 0.29 12.0 0.5 0.29 12.0 0.5 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain NADHdh PF00146.21 AIF84602.1 - 1.2e-92 310.4 22.6 1.2e-92 310.4 22.6 1.5 2 0 0 2 2 2 1 NADH dehydrogenase NDUF_B12 PF08122.12 AIF84602.1 - 1.1 9.3 5.5 0.14 12.2 0.5 2.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family Complex1_49kDa PF00346.19 AIF84603.1 - 1.3e-80 270.4 0.0 7.6e-60 202.3 0.0 2.2 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Csm1 PF12539.8 AIF84603.1 - 0.081 13.6 0.0 21 5.8 0.0 2.9 3 0 0 3 3 3 0 Chromosome segregation protein Csm1/Pcs1 Complex1_30kDa PF00329.19 AIF84604.1 - 3e-32 111.8 0.0 3.8e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit FAP PF07174.11 AIF84604.1 - 2.7 7.4 28.9 3.6 6.9 28.9 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Oxidored_q6 PF01058.22 AIF84605.1 - 4.9e-24 84.6 0.4 7e-24 84.1 0.4 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Oxidored_q4 PF00507.19 AIF84606.1 - 1.3e-18 66.9 0.9 1.8e-18 66.5 0.9 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Endonuc_Holl PF10107.9 AIF84607.1 - 8.3e-16 58.2 0.3 1e-15 58.0 0.3 1.1 1 0 0 1 1 1 1 Endonuclease related to archaeal Holliday junction resolvase Glutaredoxin PF00462.24 AIF84607.1 - 0.069 13.4 0.5 9.3 6.6 0.0 2.5 2 0 0 2 2 2 0 Glutaredoxin Methyltransf_24 PF13578.6 AIF84607.1 - 0.15 13.1 0.0 0.19 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Endonuc_Holl PF10107.9 AIF84608.1 - 3.4e-25 88.8 0.9 5.3e-25 88.1 0.8 1.3 1 1 0 1 1 1 1 Endonuclease related to archaeal Holliday junction resolvase Phe_tRNA-synt_N PF02912.18 AIF84608.1 - 0.016 15.1 1.0 0.016 15.1 1.0 1.9 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain INTS5_N PF14837.6 AIF84608.1 - 0.07 12.7 0.0 0.11 12.1 0.0 1.6 1 1 0 1 1 1 0 Integrator complex subunit 5 N-terminus Acetyltransf_1 PF00583.25 AIF84611.1 - 0.047 13.9 0.0 0.063 13.5 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Elongin_A PF06881.11 AIF84612.1 - 0.015 15.9 0.2 0.015 15.8 0.2 1.0 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Cas_Cas4 PF01930.17 AIF84613.1 - 7.7e-14 52.1 0.1 9.2e-14 51.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.7 AIF84613.1 - 7.8e-05 22.7 0.0 9.1e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Exo5 PF09810.9 AIF84613.1 - 0.09 12.3 1.0 0.32 10.4 0.0 2.0 2 1 0 2 2 2 0 Exonuclease V - a 5' deoxyribonuclease Poxvirus PF06227.12 AIF84613.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 dsDNA Poxvirus CRISPR_Cas2 PF09827.9 AIF84614.1 - 3.8e-14 52.6 1.1 4.5e-14 52.4 1.1 1.1 1 0 0 1 1 1 1 CRISPR associated protein Cas2 Cas_Cas1 PF01867.16 AIF84615.1 - 2.2e-73 246.9 0.0 2.5e-73 246.7 0.0 1.0 1 0 0 1 1 1 1 CRISPR associated protein Cas1 Cas6b_C PF17262.2 AIF84616.1 - 7.6e-36 122.7 0.2 1.1e-35 122.2 0.2 1.2 1 0 0 1 1 1 1 Cas6b C-terminal domain Cas6b_N PF17955.1 AIF84616.1 - 1.1e-14 54.4 0.1 1.9e-14 53.6 0.1 1.4 1 0 0 1 1 1 1 Cas6b N-terminal domain Cas_Cas6 PF01881.16 AIF84616.1 - 0.46 11.0 2.7 1.5 9.4 2.7 1.8 1 1 0 1 1 1 0 CRISPR associated protein Cas6 DEAD PF00270.29 AIF84617.1 - 4.8e-13 49.3 3.0 7.5e-11 42.1 0.0 3.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AIF84617.1 - 1.3e-09 38.4 0.2 6.4e-09 36.1 0.2 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AIF84617.1 - 2.7e-08 34.0 0.0 2.7e-08 34.0 0.0 3.4 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit HD_6 PF18019.1 AIF84617.1 - 4.1e-08 33.6 0.3 8.7e-08 32.5 0.3 1.5 1 0 0 1 1 1 1 HD domain HD PF01966.22 AIF84617.1 - 1.7e-06 28.3 1.7 2.8e-06 27.5 0.5 2.0 2 0 0 2 2 2 1 HD domain HDOD PF08668.12 AIF84617.1 - 5.1e-06 26.1 0.0 1.5e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 HDOD domain AAA_19 PF13245.6 AIF84617.1 - 1.2e-05 25.7 0.4 0.0002 21.7 0.0 2.8 2 1 1 3 3 3 1 AAA domain SpoU_sub_bind PF08032.12 AIF84617.1 - 0.035 14.4 0.8 0.29 11.4 0.0 2.9 4 0 0 4 4 3 0 RNA 2'-O ribose methyltransferase substrate binding Sec8_exocyst PF04048.14 AIF84617.1 - 0.039 13.8 0.7 6.8 6.6 0.0 3.1 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain YtxH PF12732.7 AIF84617.1 - 0.29 11.7 1.8 4.6 7.9 0.1 3.0 2 0 0 2 2 2 0 YtxH-like protein DUF1947 PF09183.10 AIF84617.1 - 2.6 8.4 6.0 11 6.4 0.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1947) DUF4298 PF14131.6 AIF84617.1 - 6.9 6.7 9.1 3.6 7.6 0.6 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4298) Cas_Cas5d PF09704.10 AIF84618.1 - 9.2e-11 42.0 0.0 1.9e-10 41.0 0.0 1.7 1 1 0 1 1 1 1 CRISPR-associated protein (Cas_Cas5) Cas_Cas7 PF05107.12 AIF84619.1 - 4.8e-36 124.6 0.0 6.3e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 CRISPR-associated protein Cas7 Phage_integrase PF00589.22 AIF84621.1 - 4.5e-05 23.3 0.0 0.00025 20.9 0.0 2.2 2 1 0 2 2 2 1 Phage integrase family HTH_24 PF13412.6 AIF84621.1 - 0.0072 15.9 0.0 0.02 14.4 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_38 PF13936.6 AIF84621.1 - 0.0098 15.6 1.2 0.02 14.6 0.0 2.2 3 0 0 3 3 3 1 Helix-turn-helix domain Bac_DnaA_C PF08299.11 AIF84621.1 - 0.15 12.1 0.2 1.8 8.6 0.0 2.7 3 0 0 3 3 3 0 Bacterial dnaA protein helix-turn-helix HTH_Crp_2 PF13545.6 AIF84621.1 - 0.2 11.7 0.0 2.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain FAD_oxidored PF12831.7 AIF84623.1 - 4.5e-17 62.5 0.2 5.9e-17 62.1 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 AIF84623.1 - 1.3e-11 44.7 4.9 4.1e-07 29.9 2.3 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 AIF84623.1 - 7.3e-11 41.9 0.1 2e-10 40.5 0.1 1.8 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 AIF84623.1 - 2.3e-10 40.1 0.1 3.9e-10 39.3 0.0 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 AIF84623.1 - 4.3e-09 35.6 0.6 2e-08 33.4 0.3 1.9 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 AIF84623.1 - 1.3e-08 34.4 5.0 1.2e-07 31.2 2.6 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 AIF84623.1 - 2e-07 31.1 0.1 6.8e-07 29.4 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 AIF84623.1 - 2.4e-07 30.2 1.0 3.6e-07 29.6 1.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 AIF84623.1 - 8.4e-07 28.2 0.7 0.034 13.0 0.0 2.4 1 1 1 2 2 2 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 AIF84623.1 - 1.4e-06 27.8 0.6 3.3e-06 26.6 0.6 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AIF84623.1 - 1.5e-05 24.4 0.0 2.3e-05 23.8 0.0 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 AIF84623.1 - 4.7e-05 22.8 0.1 6.7e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 AIF84623.1 - 0.00086 18.6 1.9 0.00094 18.5 0.5 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 AIF84623.1 - 0.0028 18.2 0.1 0.051 14.1 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 AIF84623.1 - 0.027 14.4 0.2 0.051 13.4 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PmbA_TldD PF01523.16 AIF84624.1 - 1.5e-52 179.2 4.8 1.8e-52 178.9 4.8 1.1 1 0 0 1 1 1 1 Putative modulator of DNA gyrase PmbA_TldD PF01523.16 AIF84625.1 - 7.6e-59 199.8 5.9 1.1e-58 199.4 5.0 1.7 2 0 0 2 2 2 1 Putative modulator of DNA gyrase GSDH PF07995.11 AIF84626.1 - 7.7e-48 163.5 0.1 2.4e-47 161.9 0.1 1.7 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase SGL PF08450.12 AIF84626.1 - 0.0023 17.6 0.0 0.016 14.8 0.0 2.1 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region CytB6-F_Fe-S PF08802.10 AIF84626.1 - 0.15 12.1 0.2 0.37 10.8 0.2 1.7 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit Cupin_2 PF07883.11 AIF84627.1 - 3.3e-09 36.3 0.4 8.1e-08 31.9 0.4 2.2 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 AIF84627.1 - 5.7e-06 26.0 0.0 7.4e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Cupin Auxin_BP PF02041.16 AIF84627.1 - 0.00027 20.7 0.0 0.00033 20.4 0.0 1.3 1 0 0 1 1 1 1 Auxin binding protein ARD PF03079.14 AIF84627.1 - 0.019 15.2 0.2 0.032 14.4 0.2 1.5 1 1 0 1 1 1 0 ARD/ARD' family AraC_binding PF02311.19 AIF84627.1 - 0.051 13.5 0.1 0.086 12.7 0.1 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain adh_short PF00106.25 AIF84628.1 - 2.2e-56 190.4 0.8 2.8e-56 190.1 0.8 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIF84628.1 - 3.7e-47 160.9 0.1 5e-47 160.4 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIF84628.1 - 2e-12 47.4 0.4 2.4e-12 47.1 0.4 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 AIF84628.1 - 0.0023 17.3 0.0 0.031 13.7 0.0 2.1 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 AIF84628.1 - 0.0087 15.5 0.2 0.013 14.9 0.2 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family FAD_binding_3 PF01494.19 AIF84628.1 - 0.011 14.9 0.1 0.024 13.9 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 AIF84628.1 - 0.021 15.1 0.3 0.057 13.7 0.3 1.8 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 AIF84628.1 - 0.024 14.2 0.5 0.049 13.2 0.5 1.5 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain THF_DHG_CYH_C PF02882.19 AIF84628.1 - 0.083 12.2 0.4 0.21 10.9 0.3 1.7 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.19 AIF84628.1 - 0.087 12.2 0.3 0.74 9.1 0.1 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Thioredoxin_10 PF17991.1 AIF84629.1 - 4.3e-14 53.3 0.0 6.3e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin like C-terminal domain AhpC-TSA PF00578.21 AIF84629.1 - 6.3e-11 42.3 0.0 1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIF84629.1 - 5e-08 32.8 0.0 6.8e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 AIF84629.1 - 2.3e-06 27.9 0.1 6.4e-06 26.4 0.1 1.9 2 1 0 2 2 2 1 Thioredoxin-like GSHPx PF00255.19 AIF84629.1 - 0.067 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Glutathione peroxidase AhpC-TSA PF00578.21 AIF84630.1 - 1.6e-38 131.4 0.0 2e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIF84630.1 - 7.8e-25 87.3 0.0 9.4e-25 87.0 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 AIF84630.1 - 8.3e-07 29.1 0.0 1.5e-06 28.3 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF899 PF05988.12 AIF84630.1 - 7.3e-05 22.4 0.0 8.2e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) SCO1-SenC PF02630.14 AIF84630.1 - 0.071 13.0 0.1 0.18 11.7 0.1 1.6 1 1 0 1 1 1 0 SCO1/SenC Rubrerythrin PF02915.17 AIF84631.1 - 0.00033 21.1 3.4 0.0026 18.2 3.5 2.1 1 1 0 1 1 1 1 Rubrerythrin Phenol_Hydrox PF02332.18 AIF84631.1 - 0.0022 17.6 0.1 1.4 8.4 0.0 2.1 2 0 0 2 2 2 2 Methane/Phenol/Toluene Hydroxylase Ferritin PF00210.24 AIF84631.1 - 0.0078 16.2 3.6 0.035 14.1 3.5 2.0 1 1 0 1 1 1 1 Ferritin-like domain LPD3 PF18798.1 AIF84631.1 - 0.018 15.3 0.4 0.79 10.0 0.3 2.3 1 1 0 1 1 1 0 Large polyvalent protein-associated domain 3 Herpes_V23 PF01802.17 AIF84631.1 - 0.023 14.1 0.2 0.025 14.0 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein Kinase-PPPase PF03618.14 AIF84631.1 - 0.032 14.0 0.1 0.037 13.8 0.1 1.1 1 0 0 1 1 1 0 Kinase/pyrophosphorylase FA_desaturase_2 PF03405.14 AIF84631.1 - 0.062 12.1 1.5 0.18 10.6 0.8 1.9 1 1 1 2 2 2 0 Fatty acid desaturase RNA_pol_N PF01194.17 AIF84633.1 - 1.3e-27 95.9 0.3 1.9e-27 95.3 0.3 1.3 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Enolase_C PF00113.22 AIF84634.1 - 1.3e-58 198.6 0.0 1.7e-58 198.2 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 AIF84634.1 - 3.3e-26 92.0 0.4 8.1e-26 90.7 0.1 1.8 2 0 0 2 2 2 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 AIF84634.1 - 4.3e-08 33.0 0.0 1.2e-07 31.5 0.0 1.5 1 1 0 1 1 1 1 Enolase C-terminal domain-like 7TMR-DISM_7TM PF07695.11 AIF84635.1 - 0.008 16.1 12.0 0.31 10.9 0.9 2.7 2 1 0 2 2 2 2 7TM diverse intracellular signalling DUF202 PF02656.15 AIF84635.1 - 0.13 12.8 0.6 0.13 12.8 0.6 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF202) Tetraspanin PF00335.20 AIF84635.1 - 0.3 10.8 5.5 3.6 7.2 1.0 2.1 1 1 1 2 2 2 0 Tetraspanin family DUF1129 PF06570.11 AIF84635.1 - 0.72 9.3 5.2 0.57 9.6 1.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) DUF3784 PF12650.7 AIF84635.1 - 1.9 8.8 12.7 0.23 11.7 1.0 2.8 4 0 0 4 4 4 0 Domain of unknown function (DUF3784) Acyl_transf_3 PF01757.22 AIF84635.1 - 2.7 7.0 13.9 41 3.1 13.5 2.4 1 1 0 1 1 1 0 Acyltransferase family Ribosomal_S2 PF00318.20 AIF84637.1 - 5e-19 68.4 0.0 1.6e-11 43.8 0.1 2.1 2 0 0 2 2 2 2 Ribosomal protein S2 SIS PF01380.22 AIF84637.1 - 0.097 12.5 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 SIS domain MEDS PF14417.6 AIF84638.1 - 8.2e-11 42.0 0.2 2.1e-10 40.7 0.1 1.7 2 0 0 2 2 2 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain KfrA_N PF11740.8 AIF84638.1 - 0.026 15.2 1.2 0.054 14.2 1.2 1.4 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term E2F_TDP PF02319.20 AIF84638.1 - 0.03 14.4 0.3 0.2 11.7 0.0 2.4 2 0 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain DUF4071 PF13281.6 AIF84638.1 - 0.045 12.8 2.0 0.29 10.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4071) NitrOD2 PF18550.1 AIF84638.1 - 0.082 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Nitrososphaera output domain 2 Memo PF01875.17 AIF84639.1 - 1.7e-75 253.7 0.0 1.9e-75 253.5 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein DUF5619 PF18505.1 AIF84639.1 - 0.025 14.5 0.1 0.063 13.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5619) GHMP_kinases_C PF08544.13 AIF84640.1 - 1.5e-18 66.9 2.2 1.5e-18 66.9 2.2 2.4 3 1 0 3 3 3 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 AIF84640.1 - 1.5e-16 60.4 0.6 1.5e-16 60.4 0.6 2.1 2 0 0 2 2 2 1 GHMP kinases N terminal domain PhoU PF01895.19 AIF84641.1 - 9.2e-16 58.1 8.3 4.3e-09 36.7 3.9 2.4 2 0 0 2 2 2 2 PhoU domain MazE_antitoxin PF04014.18 AIF84641.1 - 0.00016 21.5 0.1 0.00033 20.5 0.1 1.5 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin Exo70 PF03081.15 AIF84641.1 - 0.035 13.2 0.3 0.44 9.5 0.0 2.0 2 0 0 2 2 2 0 Exo70 exocyst complex subunit GHMP_kinases_N PF00288.26 AIF84642.1 - 5.7e-09 36.1 1.7 1.4e-08 34.8 1.7 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain PPS_PS PF02006.16 AIF84643.1 - 1.5e-73 246.1 0.7 2e-73 245.7 0.7 1.1 1 0 0 1 1 1 1 Phosphopantothenate/pantothenate synthetase Pantoate_transf PF02548.15 AIF84644.1 - 5.3e-110 366.9 0.4 6.1e-110 366.7 0.4 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 AIF84644.1 - 0.00036 20.0 0.7 0.0023 17.4 0.7 2.3 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DFP PF04127.15 AIF84645.1 - 4e-55 186.6 6.5 3.8e-54 183.3 3.0 2.3 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Flavoprotein PF02441.19 AIF84645.1 - 3.3e-36 124.4 1.0 7.2e-36 123.3 1.0 1.6 1 0 0 1 1 1 1 Flavoprotein YjeF_N PF03853.15 AIF84645.1 - 0.00077 19.4 1.6 0.22 11.4 0.0 3.1 3 1 0 3 3 3 2 YjeF-related protein N-terminus Epimerase PF01370.21 AIF84645.1 - 0.005 16.3 0.2 0.024 14.1 0.1 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family His_biosynth PF00977.21 AIF84645.1 - 0.015 14.8 0.1 0.046 13.2 0.0 1.9 2 0 0 2 2 2 0 Histidine biosynthesis protein GbpC PF08363.10 AIF84646.1 - 0.037 13.5 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 Glucan-binding protein C PrcB_C PF14343.6 AIF84646.1 - 0.09 12.9 0.4 0.68 10.1 0.1 2.4 2 1 0 2 2 2 0 PrcB C-terminal DUF2007 PF09413.10 AIF84646.1 - 0.1 12.8 0.0 0.3 11.3 0.0 1.8 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein CARDB PF07705.11 AIF84646.1 - 0.1 12.8 1.0 0.73 10.1 0.1 2.7 1 1 1 2 2 2 0 CARDB Peptidase_M24 PF00557.24 AIF84647.1 - 4.9e-58 196.3 0.1 6.3e-58 195.9 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 AIF84647.1 - 1.6e-10 41.8 0.0 3.7e-10 40.5 0.0 1.7 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain AAA PF00004.29 AIF84648.1 - 1.4e-98 326.4 0.0 2.2e-48 164.0 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AIF84648.1 - 6.2e-27 93.1 2.3 6.6e-14 51.4 0.1 2.9 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 AIF84648.1 - 1.7e-23 82.6 0.7 4.9e-23 81.1 0.7 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 AIF84648.1 - 3e-15 56.3 0.0 5.8e-08 32.6 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AIF84648.1 - 4.1e-15 56.6 1.5 7.1e-05 23.2 0.0 5.0 3 2 1 4 4 4 2 AAA ATPase domain AAA_2 PF07724.14 AIF84648.1 - 1.2e-14 54.7 0.0 8e-06 26.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.17 AIF84648.1 - 1.1e-13 50.7 0.0 3.1e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 AIF84648.1 - 1.4e-11 44.8 0.4 0.0051 17.1 0.0 4.0 2 2 1 3 3 3 2 AAA domain AAA_5 PF07728.14 AIF84648.1 - 9.2e-10 38.7 0.8 0.0022 18.0 0.1 4.2 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 AIF84648.1 - 2.7e-09 37.3 0.0 0.00016 21.9 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 AIF84648.1 - 6.7e-09 35.9 0.0 0.0011 19.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 AIF84648.1 - 8.9e-09 35.0 0.0 0.003 16.8 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 AIF84648.1 - 9.9e-08 32.6 0.0 0.0099 16.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 AIF84648.1 - 1.8e-07 31.1 0.0 0.009 15.8 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 AIF84648.1 - 2.2e-06 28.0 0.1 0.071 13.5 0.0 2.8 3 0 0 3 3 2 2 RNA helicase Mg_chelatase PF01078.21 AIF84648.1 - 2.8e-06 26.8 0.7 0.062 12.7 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 AIF84648.1 - 3.3e-06 26.8 0.7 1.8 8.1 0.1 3.8 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.6 AIF84648.1 - 3.3e-06 27.4 0.1 0.011 16.0 0.0 2.8 3 0 0 3 3 2 2 AAA domain Zeta_toxin PF06414.12 AIF84648.1 - 4.6e-06 26.1 0.1 0.11 11.8 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_24 PF13479.6 AIF84648.1 - 1e-05 25.4 0.0 0.035 13.8 0.0 2.9 3 0 0 3 3 2 2 AAA domain Sigma54_activat PF00158.26 AIF84648.1 - 1.2e-05 25.1 0.5 0.37 10.5 0.0 3.9 4 1 0 4 4 3 2 Sigma-54 interaction domain AAA_7 PF12775.7 AIF84648.1 - 1.5e-05 24.6 0.0 0.13 11.7 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region TsaE PF02367.17 AIF84648.1 - 2.4e-05 24.3 0.0 0.19 11.7 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 AIF84648.1 - 3e-05 23.6 0.3 0.17 11.3 0.0 2.8 3 0 0 3 3 2 2 PhoH-like protein DUF2075 PF09848.9 AIF84648.1 - 4.7e-05 22.8 0.0 0.056 12.7 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 AIF84648.1 - 9.5e-05 22.3 0.0 0.34 10.8 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 AIF84648.1 - 9.6e-05 21.7 0.0 0.2 10.8 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain ATPase_2 PF01637.18 AIF84648.1 - 0.00013 22.0 0.1 1 9.2 0.0 3.2 2 2 0 3 3 2 2 ATPase domain predominantly from Archaea NACHT PF05729.12 AIF84648.1 - 0.00016 21.6 0.1 0.27 11.2 0.0 3.2 3 0 0 3 3 3 1 NACHT domain ABC_tran PF00005.27 AIF84648.1 - 0.00017 22.1 0.0 0.38 11.3 0.0 2.5 2 0 0 2 2 2 1 ABC transporter DUF815 PF05673.13 AIF84648.1 - 0.00017 20.9 0.0 0.29 10.3 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Molydop_binding PF01568.21 AIF84648.1 - 0.00021 21.3 0.3 0.0039 17.2 0.1 2.5 2 1 1 3 3 2 1 Molydopterin dinucleotide binding domain AAA_30 PF13604.6 AIF84648.1 - 0.00028 20.7 1.7 0.22 11.2 0.0 3.0 3 0 0 3 3 2 2 AAA domain Vps4_C PF09336.10 AIF84648.1 - 0.00033 20.6 0.7 0.98 9.5 0.1 2.7 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain AAA_11 PF13086.6 AIF84648.1 - 0.00033 20.5 0.3 0.32 10.8 0.0 2.5 3 0 0 3 3 2 1 AAA domain ATPase PF06745.13 AIF84648.1 - 0.00038 19.9 0.1 1.9 7.8 0.0 3.4 3 0 0 3 3 3 1 KaiC Bac_DnaA PF00308.18 AIF84648.1 - 0.00096 19.0 0.0 3 7.6 0.0 3.4 3 1 0 3 3 3 1 Bacterial dnaA protein AAA_19 PF13245.6 AIF84648.1 - 0.0013 19.1 0.8 2.2 8.6 0.0 2.9 3 0 0 3 3 2 1 AAA domain NTPase_1 PF03266.15 AIF84648.1 - 0.0014 18.5 0.3 0.72 9.7 0.0 3.1 2 1 1 3 3 3 1 NTPase Parvo_NS1 PF01057.17 AIF84648.1 - 0.0016 17.6 0.1 1.1 8.3 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_17 PF13207.6 AIF84648.1 - 0.0017 18.8 0.0 2.5 8.5 0.0 3.0 3 0 0 3 3 2 1 AAA domain AFG1_ATPase PF03969.16 AIF84648.1 - 0.0018 17.2 0.0 1.5 7.6 0.0 2.4 2 0 0 2 2 2 2 AFG1-like ATPase TniB PF05621.11 AIF84648.1 - 0.0041 16.6 0.1 4.8 6.6 0.0 3.7 3 1 1 4 4 3 0 Bacterial TniB protein Viral_helicase1 PF01443.18 AIF84648.1 - 0.0087 15.8 0.0 1.2 8.9 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase LID PF17916.1 AIF84648.1 - 0.019 14.6 1.5 4.3 7.1 0.2 2.8 2 0 0 2 2 2 0 LIM interaction domain (LID) Cytidylate_kin PF02224.18 AIF84648.1 - 0.031 14.0 0.1 2.8 7.6 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase T2SSE PF00437.20 AIF84648.1 - 0.035 13.2 0.0 9.4 5.2 0.0 2.7 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activ_2 PF14532.6 AIF84648.1 - 0.052 13.7 0.0 17 5.5 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Hydin_ADK PF17213.3 AIF84648.1 - 0.06 13.6 0.3 2.9 8.1 0.1 2.5 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Guanylate_kin PF00625.21 AIF84648.1 - 0.065 12.9 0.2 12 5.6 0.0 3.5 2 2 2 4 4 3 0 Guanylate kinase UFD1 PF03152.14 AIF84648.1 - 0.068 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 ResIII PF04851.15 AIF84648.1 - 0.068 13.2 0.0 11 6.0 0.0 2.6 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit CPT PF07931.12 AIF84648.1 - 0.082 12.7 0.0 4.2 7.2 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DAP3 PF10236.9 AIF84648.1 - 0.13 11.5 0.0 17 4.4 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Zot PF05707.12 AIF84648.1 - 0.13 11.9 0.0 1.9 8.1 0.0 2.6 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) Cytidylate_kin2 PF13189.6 AIF84648.1 - 0.13 12.4 0.0 1.2 9.2 0.0 2.5 3 0 0 3 3 2 0 Cytidylate kinase-like family Torsin PF06309.11 AIF84648.1 - 0.13 12.3 0.0 3.3 7.8 0.0 2.4 2 0 0 2 2 2 0 Torsin RibD_C PF01872.17 AIF84649.1 - 1.3e-16 61.0 0.0 7.5e-11 42.2 0.0 2.0 1 1 1 2 2 2 2 RibD C-terminal domain DHFR_1 PF00186.19 AIF84649.1 - 2.2e-09 37.2 0.0 2.4e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase Aminotran_5 PF00266.19 AIF84650.1 - 1.2e-33 116.6 0.0 1.6e-33 116.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 AIF84650.1 - 0.0037 15.9 0.0 0.0054 15.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF742 PF05331.11 AIF84652.1 - 0.049 13.5 0.0 0.089 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF742) FliE PF02049.18 AIF84652.1 - 0.062 13.4 0.2 0.097 12.8 0.2 1.2 1 0 0 1 1 1 0 Flagellar hook-basal body complex protein FliE Sacchrp_dh_C PF16653.5 AIF84652.1 - 0.074 13.1 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase C-terminal domain Osmo_CC PF08946.10 AIF84652.1 - 0.12 12.7 0.4 0.19 12.0 0.4 1.3 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Abhydrolase_6 PF12697.7 AIF84654.1 - 6.1e-19 69.5 0.1 7.3e-19 69.2 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AIF84654.1 - 1.7e-07 30.7 0.0 0.0076 15.5 0.0 3.2 3 0 0 3 3 3 3 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 AIF84654.1 - 1.7e-07 31.1 0.1 7e-07 29.2 0.1 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 AIF84654.1 - 3.8e-06 26.9 0.0 0.00054 19.9 0.0 2.2 1 1 0 1 1 1 1 Serine hydrolase Abhydrolase_1 PF00561.20 AIF84654.1 - 2.3e-05 24.2 0.9 0.01 15.5 0.3 2.9 1 1 0 2 2 2 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 AIF84654.1 - 0.02 13.8 0.0 0.052 12.5 0.0 1.7 1 1 1 2 2 2 0 Chlorophyllase enzyme Chlorophyllase PF07224.11 AIF84654.1 - 0.027 13.5 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Amino_oxidase PF01593.24 AIF84655.1 - 3.3e-18 66.2 0.2 4.5e-16 59.2 0.5 2.9 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 AIF84655.1 - 1.3e-14 54.2 0.7 3.5e-14 52.8 0.4 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AIF84655.1 - 1.2e-12 48.1 1.2 2.4e-12 47.1 1.2 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 AIF84655.1 - 9.3e-10 37.8 0.8 0.00014 20.7 0.2 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 AIF84655.1 - 8.4e-09 35.1 0.9 0.00011 21.5 0.1 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 AIF84655.1 - 3.2e-07 29.8 3.2 1.3e-05 24.4 0.7 2.6 3 0 0 3 3 3 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 AIF84655.1 - 1.2e-06 27.9 1.3 2.1e-06 27.1 1.3 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 AIF84655.1 - 6.9e-06 25.5 0.3 1.2e-05 24.8 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 AIF84655.1 - 8.6e-06 25.3 0.5 2.9e-05 23.6 0.3 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 AIF84655.1 - 2.9e-05 23.4 0.0 7.5e-05 22.1 0.1 1.6 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 AIF84655.1 - 4.6e-05 23.4 0.7 0.074 13.0 0.0 2.6 3 0 0 3 3 3 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 AIF84655.1 - 0.00018 20.9 0.1 0.49 9.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 AIF84655.1 - 0.00033 19.8 0.6 0.0025 16.9 0.1 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 AIF84655.1 - 0.00033 21.2 1.7 0.0012 19.4 0.4 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 AIF84655.1 - 0.011 15.1 0.2 0.023 14.0 0.2 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 AIF84655.1 - 0.012 14.5 0.4 0.017 14.0 0.4 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Viral_cys_rich PF08008.12 AIF84655.1 - 0.021 14.8 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 Viral cysteine rich 3HCDH_N PF02737.18 AIF84655.1 - 0.036 14.0 0.1 0.076 12.9 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MCRA PF06100.11 AIF84655.1 - 0.11 11.2 0.7 0.15 10.8 0.1 1.5 2 0 0 2 2 2 0 MCRA family UDPG_MGDP_dh_N PF03721.14 AIF84655.1 - 0.13 11.8 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain RibD_C PF01872.17 AIF84656.1 - 1.6e-25 90.1 0.0 2.9e-25 89.3 0.0 1.4 1 1 0 1 1 1 1 RibD C-terminal domain Chorion_3 PF05387.11 AIF84659.1 - 0.57 9.8 3.4 0.63 9.6 3.4 1.1 1 0 0 1 1 1 0 Chorion family 3 DUF1077 PF06417.12 AIF84660.1 - 0.21 11.6 0.5 0.28 11.2 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1077) Peptidase_S24 PF00717.23 AIF84662.1 - 2.7e-09 36.9 0.6 4.5e-09 36.1 0.6 1.4 1 0 0 1 1 1 1 Peptidase S24-like YlaC PF10777.9 AIF84662.1 - 0.95 9.3 4.9 0.12 12.2 0.8 1.8 2 1 0 2 2 2 0 Inner membrane protein YlaC SnoaL_2 PF12680.7 AIF84663.1 - 5.3e-08 33.4 0.0 6.2e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain YozE_SAM_like PF06855.12 AIF84663.1 - 0.14 12.3 0.8 0.25 11.6 0.2 1.7 2 0 0 2 2 2 0 YozE SAM-like fold FKBP26_C PF18046.1 AIF84664.1 - 1.2e-17 63.8 1.0 2.1e-17 63.0 1.0 1.4 1 0 0 1 1 1 1 FKBP26_C-terminal FKBP_C PF00254.28 AIF84664.1 - 8.8e-13 48.4 0.0 1.9e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Tn7_Tnp_TnsA_C PF08721.11 AIF84664.1 - 0.012 16.2 0.0 2 9.1 0.0 2.5 2 1 0 2 2 2 0 TnsA endonuclease C terminal Fe-S_biosyn PF01521.20 AIF84665.1 - 2.4e-26 92.1 0.0 2.7e-26 91.9 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF2749 PF10907.8 AIF84666.1 - 0.21 11.8 4.8 0.23 11.7 4.8 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2749) HTH_5 PF01022.20 AIF84667.1 - 5e-06 26.3 0.0 7.6e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_45 PF14947.6 AIF84667.1 - 2.8e-05 24.0 0.1 4.9e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_20 PF12840.7 AIF84667.1 - 0.00034 20.6 0.0 0.0007 19.6 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4364 PF14277.6 AIF84667.1 - 0.0055 16.5 0.0 0.0098 15.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) TIMP PF00965.17 AIF84668.1 - 0.00034 20.5 0.1 0.00063 19.6 0.1 1.4 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase Gram_pos_anchor PF00746.21 AIF84668.1 - 0.14 12.1 0.0 0.45 10.5 0.0 1.9 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Bac_luciferase PF00296.20 AIF84669.1 - 7.4e-54 183.3 0.0 9.6e-54 182.9 0.0 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Putative_PNPOx PF01243.20 AIF84670.1 - 1.5e-12 47.5 0.0 2.1e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AIF84670.1 - 1.6e-06 28.2 0.0 2e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase AsnC_trans_reg PF01037.21 AIF84671.1 - 2.9e-13 49.6 0.1 3.2e-13 49.5 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIF84671.1 - 0.065 13.3 0.3 0.17 11.9 0.3 1.6 1 1 0 1 1 1 0 NapD protein Gln-synt_C PF00120.24 AIF84672.1 - 2.1e-106 355.8 0.0 2.5e-106 355.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 AIF84672.1 - 1.1e-16 60.3 0.0 4.6e-16 58.3 0.0 2.1 2 0 0 2 2 2 1 Glutamine synthetase, beta-Grasp domain DUF1582 PF07621.11 AIF84672.1 - 0.025 14.5 0.5 0.074 13.0 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1582) HTH_24 PF13412.6 AIF84673.1 - 7.3e-16 57.5 0.0 1.6e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF84673.1 - 1.8e-15 56.4 0.0 3.7e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 AIF84673.1 - 9e-12 44.8 0.1 1.5e-11 44.1 0.1 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain Fe_dep_repress PF01325.19 AIF84673.1 - 7.7e-06 26.0 0.1 1.8e-05 24.8 0.1 1.6 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_5 PF01022.20 AIF84673.1 - 9.6e-06 25.4 0.0 2.7e-05 24.0 0.0 1.8 2 0 0 2 2 1 1 Bacterial regulatory protein, arsR family TrmB PF01978.19 AIF84673.1 - 4e-05 23.4 0.3 0.0001 22.1 0.2 1.7 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.6 AIF84673.1 - 0.00011 21.9 0.0 0.00021 21.0 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain MarR PF01047.22 AIF84673.1 - 0.00011 22.1 0.0 0.00023 21.0 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 AIF84673.1 - 0.00039 20.4 0.0 0.00062 19.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.6 AIF84673.1 - 0.00046 20.2 0.0 0.0007 19.7 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.6 AIF84673.1 - 0.00057 19.8 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 AIF84673.1 - 0.00058 20.2 0.1 0.0024 18.2 0.0 2.0 2 0 0 2 2 2 1 Transcriptional regulator HTH_11 PF08279.12 AIF84673.1 - 0.00074 19.4 0.0 0.0017 18.3 0.0 1.8 1 1 0 1 1 1 1 HTH domain HTH_38 PF13936.6 AIF84673.1 - 0.0008 19.1 0.0 0.0027 17.4 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 AIF84673.1 - 0.00089 19.1 0.0 0.0018 18.1 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_10 PF04967.12 AIF84673.1 - 0.0065 16.2 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 HTH DNA binding domain HTH_50 PF18024.1 AIF84673.1 - 0.0082 15.7 0.0 0.03 13.9 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_30 PF13556.6 AIF84673.1 - 0.0085 15.9 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain Sigma70_r4_2 PF08281.12 AIF84673.1 - 0.012 15.3 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 GntR PF00392.21 AIF84673.1 - 0.015 14.9 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_IclR PF09339.10 AIF84673.1 - 0.018 14.9 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_Mga PF08280.11 AIF84673.1 - 0.027 14.5 0.0 0.066 13.2 0.0 1.7 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain IF2_N PF04760.15 AIF84673.1 - 0.033 14.0 0.0 0.071 12.9 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region HTH_CodY PF08222.11 AIF84673.1 - 0.045 13.3 0.0 0.086 12.4 0.0 1.5 1 0 0 1 1 1 0 CodY helix-turn-helix domain Trp_repressor PF01371.19 AIF84673.1 - 0.046 13.9 0.1 0.1 12.7 0.0 1.7 2 0 0 2 2 1 0 Trp repressor protein HTH_29 PF13551.6 AIF84673.1 - 0.049 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix HTH_47 PF16221.5 AIF84673.1 - 0.05 13.2 0.0 0.096 12.3 0.0 1.4 1 0 0 1 1 1 0 winged helix-turn-helix HTH_1 PF00126.27 AIF84673.1 - 0.055 13.4 0.0 0.097 12.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family HTH_19 PF12844.7 AIF84673.1 - 0.071 13.1 0.1 0.32 11.0 0.1 2.2 1 1 0 1 1 1 0 Helix-turn-helix domain TetR_N PF00440.23 AIF84673.1 - 0.077 12.8 0.0 0.49 10.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family HTH_36 PF13730.6 AIF84673.1 - 0.1 12.6 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_7 PF02796.15 AIF84673.1 - 0.11 12.6 0.0 0.3 11.2 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_Tnp_ISL3 PF13542.6 AIF84673.1 - 0.14 11.6 0.0 0.65 9.5 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 ELFV_dehydrog PF00208.21 AIF84674.1 - 5.7e-75 252.2 4.6 5.7e-75 252.2 4.6 1.4 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 AIF84674.1 - 3e-60 201.8 0.0 5.9e-60 200.8 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2-Hacid_dh_C PF02826.19 AIF84674.1 - 0.044 13.2 0.2 0.083 12.2 0.2 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MttA_Hcf106 PF02416.16 AIF84675.1 - 3.9e-12 45.3 0.3 5.9e-12 44.7 0.3 1.4 1 1 0 1 1 1 1 mttA/Hcf106 family DUF4389 PF14333.6 AIF84675.1 - 0.083 12.8 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) Translin PF01997.16 AIF84676.1 - 1e-08 35.4 0.1 4.8e-07 30.0 0.1 2.2 1 1 0 1 1 1 1 Translin family IF-2 PF11987.8 AIF84676.1 - 0.045 13.9 0.3 0.11 12.6 0.3 1.8 1 1 0 1 1 1 0 Translation-initiation factor 2 Osmo_CC PF08946.10 AIF84676.1 - 0.11 12.8 3.2 0.13 12.5 0.3 2.4 2 0 0 2 2 2 0 Osmosensory transporter coiled coil SeqA_N PF17206.3 AIF84676.1 - 0.19 11.1 0.7 0.4 10.0 0.1 1.8 2 0 0 2 2 2 0 SeqA protein N-terminal domain Hjc PF01870.18 AIF84677.1 - 7.2e-09 35.5 0.0 1e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Archaeal holliday junction resolvase (hjc) BsuBI_PstI_RE PF06616.11 AIF84677.1 - 0.01 15.1 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease domain VRR_NUC PF08774.11 AIF84677.1 - 0.018 15.1 0.0 0.034 14.2 0.0 1.5 1 0 0 1 1 1 0 VRR-NUC domain Cyclophil_like PF04126.13 AIF84678.1 - 5e-30 103.8 0.0 6e-30 103.5 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin-like Cyclophil_like2 PF18050.1 AIF84678.1 - 4.8e-06 26.5 0.0 8.9e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 Cyclophilin-like family DUF3830 PF12903.7 AIF84678.1 - 0.023 14.4 0.0 0.14 11.8 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3830) SNase PF00565.17 AIF84679.1 - 3.7e-06 27.4 0.0 6.4e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Y_Y_Y PF07495.13 AIF84679.1 - 0.058 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Y_Y_Y domain TFIIB PF00382.19 AIF84680.1 - 1.4e-30 105.2 1.3 1.6e-14 53.7 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIF84680.1 - 1.4e-10 40.5 0.1 2.3e-10 39.8 0.1 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Sigma70_r4 PF04545.16 AIF84680.1 - 4.4e-05 22.9 0.1 0.0022 17.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_AsnC-type PF13404.6 AIF84680.1 - 0.00025 20.8 0.1 0.0026 17.6 0.0 2.7 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain HARE-HTH PF05066.13 AIF84680.1 - 0.002 18.5 0.1 0.0076 16.6 0.0 2.0 2 0 0 2 2 2 1 HB1, ASXL, restriction endonuclease HTH domain Rrf2 PF02082.20 AIF84680.1 - 0.003 17.9 0.2 4.5 7.7 0.0 2.7 2 1 0 2 2 2 2 Transcriptional regulator HTH_11 PF08279.12 AIF84680.1 - 0.0066 16.4 0.8 0.065 13.2 0.1 2.5 3 0 0 3 3 3 1 HTH domain LacI PF00356.21 AIF84680.1 - 0.0072 16.1 2.4 0.81 9.5 0.3 3.3 3 0 0 3 3 3 1 Bacterial regulatory proteins, lacI family HTH_Tnp_ISL3 PF13542.6 AIF84680.1 - 0.023 14.1 0.0 0.13 11.7 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Sigma70_r4_2 PF08281.12 AIF84680.1 - 0.024 14.3 0.1 0.12 12.1 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.6 AIF84680.1 - 0.036 13.9 0.2 0.2 11.5 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain Phage_terminase PF10668.9 AIF84680.1 - 0.042 13.9 0.0 2 8.5 0.0 2.4 2 0 0 2 2 2 0 Phage terminase small subunit HTH_36 PF13730.6 AIF84680.1 - 0.053 13.5 1.1 1.5 8.8 0.0 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain RB_B PF01857.20 AIF84680.1 - 0.055 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain TetR_N PF00440.23 AIF84680.1 - 0.06 13.2 0.1 9.6 6.1 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family GerE PF00196.19 AIF84680.1 - 0.07 12.7 0.7 0.57 9.8 0.0 2.5 3 0 0 3 3 3 0 Bacterial regulatory proteins, luxR family HTH_Crp_2 PF13545.6 AIF84680.1 - 0.23 11.5 1.2 1.7 8.7 0.1 2.6 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain ZT_dimer PF16916.5 AIF84681.1 - 1e-42 144.1 11.7 2e-16 59.9 0.2 3.3 3 0 0 3 3 3 3 Dimerisation domain of Zinc Transporter Cation_efflux PF01545.21 AIF84681.1 - 3.9e-31 108.4 17.4 5.1e-31 108.0 17.4 1.2 1 0 0 1 1 1 1 Cation efflux family AMP-binding_C_2 PF14535.6 AIF84681.1 - 0.0024 18.2 3.6 0.014 15.6 0.2 2.9 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain Carb_kinase PF01256.17 AIF84682.1 - 1.3e-39 136.2 0.4 1.5e-39 136.0 0.4 1.0 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 AIF84682.1 - 0.00012 21.6 0.2 0.00016 21.1 0.2 1.4 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.12 AIF84682.1 - 0.01 15.2 0.2 0.03 13.7 0.2 1.8 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase adh_short PF00106.25 AIF84683.1 - 8.7e-52 175.4 0.1 1.1e-51 175.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIF84683.1 - 1.4e-34 119.7 0.0 1.7e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIF84683.1 - 1.2e-11 44.8 0.0 1.9e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 AIF84683.1 - 1.2e-07 31.4 0.0 1.8e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 AIF84683.1 - 8e-06 25.9 0.0 1.9e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 AIF84683.1 - 9.4e-05 22.0 0.0 0.00044 19.8 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family tRNA_bind PF01588.20 AIF84684.1 - 9.5e-20 70.5 0.0 1.3e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Putative tRNA binding domain PAC2 PF09754.9 AIF84685.1 - 3e-29 102.5 0.0 3.8e-29 102.2 0.0 1.0 1 0 0 1 1 1 1 PAC2 family NAD_binding_2 PF03446.15 AIF84686.1 - 4e-35 121.3 0.6 7.3e-35 120.5 0.2 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 AIF84686.1 - 4.9e-25 88.1 0.8 1.7e-24 86.4 0.5 1.9 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 AIF84686.1 - 3.3e-05 24.4 0.4 0.00039 20.9 0.0 2.5 1 1 2 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 AIF84686.1 - 0.00038 20.4 0.0 0.46 10.4 0.0 2.3 1 1 1 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ORC2 PF04084.14 AIF84686.1 - 0.1 11.5 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 2 Radical_SAM PF04055.21 AIF84688.1 - 4.3e-12 46.7 0.8 5.7e-12 46.3 0.1 1.6 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 AIF84688.1 - 0.0042 17.3 0.0 0.0098 16.2 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 AIF84688.1 - 0.0096 16.0 0.1 0.03 14.5 0.1 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain DUF5131 PF07505.11 AIF84688.1 - 0.024 14.1 0.2 0.15 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF5131) Thiamine_BP PF01910.17 AIF84688.1 - 0.063 13.2 0.0 2.8 7.9 0.0 2.8 2 1 1 3 3 3 0 Thiamine-binding protein DUF1848 PF08902.11 AIF84688.1 - 1.3 8.7 6.9 3 7.5 5.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1848) zf-C2HC_2 PF13913.6 AIF84689.1 - 0.0072 16.2 0.2 0.013 15.4 0.2 1.5 1 0 0 1 1 1 1 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 AIF84689.1 - 0.035 14.2 0.0 0.035 14.2 0.0 1.6 2 0 0 2 2 2 0 Zinc ribbon domain Sgf11 PF08209.11 AIF84689.1 - 0.056 13.0 0.3 0.056 13.0 0.3 1.6 1 1 0 1 1 1 0 Sgf11 (transcriptional regulation protein) CxC7 PF18866.1 AIF84689.1 - 0.2 11.8 2.0 0.63 10.2 0.0 1.9 1 1 1 2 2 2 0 CxC7 like cysteine cluster associated with KDZ transposases NUDIX PF00293.28 AIF84690.1 - 6.3e-20 71.5 0.0 7.7e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain DUF4916 PF16262.5 AIF84690.1 - 0.00048 19.7 0.0 0.0023 17.5 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4916) NUDIX_4 PF14815.6 AIF84690.1 - 0.002 18.1 0.0 0.0028 17.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Coatomer_E PF04733.14 AIF84691.1 - 0.034 13.6 0.5 0.047 13.1 0.5 1.2 1 0 0 1 1 1 0 Coatomer epsilon subunit UPF0051 PF01458.17 AIF84692.1 - 1.6e-74 250.3 0.2 2.2e-74 249.8 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) UPF0051 PF01458.17 AIF84693.1 - 2.6e-56 190.7 0.3 3.8e-56 190.2 0.3 1.2 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) Peptidase_C23 PF05379.11 AIF84693.1 - 0.069 13.3 0.1 4.2 7.6 0.0 2.5 2 0 0 2 2 2 0 Carlavirus endopeptidase Rieske PF00355.26 AIF84694.1 - 3.6e-16 58.9 0.0 4.1e-16 58.7 0.0 1.0 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIF84694.1 - 1.3e-12 47.5 0.0 1.5e-12 47.3 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Aminotran_5 PF00266.19 AIF84695.1 - 1.1e-151 505.0 0.7 1.3e-151 504.8 0.7 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 AIF84695.1 - 0.00063 18.4 0.0 0.00097 17.8 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 AIF84695.1 - 0.0013 18.1 0.1 0.0025 17.2 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 AIF84695.1 - 0.0039 16.4 0.1 0.0067 15.6 0.1 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II SelA PF03841.13 AIF84695.1 - 0.085 11.8 0.1 0.28 10.1 0.1 1.8 1 1 0 1 1 1 0 L-seryl-tRNA selenium transferase NifU_N PF01592.16 AIF84696.1 - 4.3e-33 114.2 0.0 5.4e-33 113.9 0.0 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Lip_prot_lig_C PF10437.9 AIF84696.1 - 0.053 13.5 0.4 0.095 12.7 0.3 1.7 1 1 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus TSCPD PF12637.7 AIF84696.1 - 0.061 13.6 0.1 0.085 13.1 0.1 1.3 1 0 0 1 1 1 0 TSCPD domain DZR PF12773.7 AIF84697.1 - 0.022 14.8 1.1 0.033 14.2 1.1 1.3 1 0 0 1 1 1 0 Double zinc ribbon DUF35_N PF12172.8 AIF84697.1 - 0.025 14.4 1.1 0.27 11.1 1.1 2.1 1 1 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Peptidase_C69 PF03577.15 AIF84697.1 - 0.044 12.7 0.0 0.051 12.5 0.0 1.2 1 0 0 1 1 1 0 Peptidase family C69 Phage_TAC_12 PF12363.8 AIF84697.1 - 0.053 13.9 0.0 0.11 13.0 0.0 1.6 1 1 0 1 1 1 0 Phage tail assembly chaperone protein, TAC Zn-ribbon_8 PF09723.10 AIF84697.1 - 0.084 13.0 3.2 0.26 11.4 3.2 1.9 1 1 0 1 1 1 0 Zinc ribbon domain DUF1002 PF06207.11 AIF84697.1 - 0.19 11.3 0.1 0.24 10.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) zf-trcl PF13451.6 AIF84697.1 - 1.2 9.1 9.7 4 7.4 3.3 2.2 1 1 1 2 2 2 0 Probable zinc-ribbon domain PAP2 PF01569.21 AIF84698.1 - 5.4e-18 65.1 7.1 5.4e-18 65.1 7.1 2.4 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 AIF84698.1 - 4.8e-11 42.7 7.7 4.8e-11 42.7 7.7 2.0 1 1 1 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 AIF84698.1 - 0.033 14.7 0.7 0.033 14.7 0.7 2.6 3 0 0 3 3 3 0 PAP2 superfamily C-terminal DUF4064 PF13273.6 AIF84698.1 - 2.9 8.2 13.5 67 3.8 0.1 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) FAD_binding_2 PF00890.24 AIF84700.1 - 1.8e-06 27.3 0.3 0.016 14.4 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 AIF84700.1 - 1e-05 25.3 0.3 0.057 13.0 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 AIF84700.1 - 0.015 14.2 0.1 0.3 9.9 0.1 2.2 2 0 0 2 2 2 0 Tryptophan halogenase Thi4 PF01946.17 AIF84700.1 - 0.023 13.9 0.6 0.14 11.4 0.9 2.2 2 1 0 2 2 2 0 Thi4 family GDI PF00996.18 AIF84700.1 - 0.038 12.5 0.0 0.11 11.0 0.0 1.7 2 0 0 2 2 2 0 GDP dissociation inhibitor Pyr_redox_2 PF07992.14 AIF84700.1 - 0.063 12.5 1.4 0.3 10.3 0.1 2.2 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AIF84700.1 - 0.17 12.2 0.1 0.57 10.5 0.1 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 AIF84700.1 - 0.18 10.5 0.8 0.43 9.2 0.2 1.8 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.7 AIF84700.1 - 0.21 10.9 1.5 0.62 9.3 1.5 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase HAD_2 PF13419.6 AIF84701.1 - 1.1e-17 64.7 0.0 1.8e-17 64.0 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AIF84701.1 - 1.2e-11 44.5 0.0 2.1e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 AIF84701.1 - 1.2e-09 38.8 0.0 1.6e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 AIF84701.1 - 0.00091 18.9 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase DUF962 PF06127.11 AIF84702.1 - 0.00065 19.7 0.2 0.00088 19.3 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF962) HIT PF01230.23 AIF84703.1 - 3.2e-25 88.7 0.1 4.1e-25 88.4 0.1 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 AIF84703.1 - 3.1e-15 56.6 0.0 4.1e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 AIF84703.1 - 0.003 17.4 0.1 0.0056 16.5 0.1 1.4 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Gmx_para_CXXCG PF09535.10 AIF84703.1 - 0.16 11.2 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (Gmx_para_CXXCG) PAPS_reduct PF01507.19 AIF84705.1 - 6.8e-44 150.0 0.0 8.5e-44 149.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family ATP-sulfurylase PF01747.17 AIF84706.1 - 2.5e-84 282.0 0.4 3.1e-84 281.7 0.4 1.1 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 AIF84706.1 - 1.6e-39 135.1 0.0 2.8e-39 134.3 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain Big_9 PF17963.1 AIF84707.1 - 7.5e-194 629.2 304.5 6.3e-22 78.1 9.3 18.2 18 3 0 18 18 14 14 Bacterial Ig domain Cadherin_5 PF17892.1 AIF84707.1 - 3.9e-109 357.0 156.8 8.1e-12 45.0 7.9 15.6 17 0 0 17 17 17 14 Cadherin-like domain Cadherin_4 PF17803.1 AIF84707.1 - 1.1e-97 320.7 261.7 1.6e-13 51.1 6.9 18.9 15 2 3 18 18 16 14 Bacterial cadherin-like domain Cadherin_3 PF16184.5 AIF84707.1 - 3.5e-50 168.6 49.4 7.8e-06 25.9 1.6 18.8 14 10 0 14 14 14 12 Cadherin-like He_PIG PF05345.12 AIF84707.1 - 7.3e-26 90.1 40.2 3.8e-10 39.8 3.4 18.3 16 4 0 16 16 15 5 Putative Ig domain CHB_HEX_C_1 PF13290.6 AIF84707.1 - 9.4e-20 70.4 7.2 9.4e-20 70.4 7.2 6.3 5 0 0 5 5 5 1 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 AIF84707.1 - 3e-13 49.7 5.3 3e-13 49.7 5.3 4.1 4 0 0 4 4 3 1 Fn3 associated Big_7 PF17957.1 AIF84707.1 - 1.5e-05 25.7 18.7 0.00011 22.9 5.6 18.7 12 4 6 19 19 14 4 Bacterial Ig domain Y_Y_Y PF07495.13 AIF84707.1 - 5.8e-05 23.0 2.1 0.92 9.5 0.0 5.0 4 0 0 4 4 4 2 Y_Y_Y domain SCP2_2 PF13530.6 AIF84707.1 - 0.0016 18.8 5.4 3 8.3 0.1 7.2 9 1 0 9 9 8 1 Sterol carrier protein domain DUF4625 PF15418.6 AIF84707.1 - 0.0075 16.5 0.6 1.4e+02 2.6 0.0 6.1 5 1 1 6 6 6 0 Domain of unknown function (DUF4625) fn3 PF00041.21 AIF84707.1 - 0.01 16.1 0.7 13 6.2 0.1 4.6 2 0 0 2 2 2 0 Fibronectin type III domain DUF1838 PF08894.11 AIF84707.1 - 0.046 13.4 0.0 10 5.8 0.0 4.4 6 1 0 6 6 6 0 Protein of unknown function (DUF1838) SHR-BD PF06650.12 AIF84709.1 - 0.049 13.0 0.0 0.061 12.7 0.0 1.1 1 0 0 1 1 1 0 SHR-binding domain of vacuolar-sorting associated protein 13 HTH_5 PF01022.20 AIF84711.1 - 1.2e-09 37.9 0.0 2.1e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIF84711.1 - 1.8e-07 31.1 0.0 3e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 AIF84711.1 - 0.00027 20.8 0.0 0.0004 20.2 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_45 PF14947.6 AIF84711.1 - 0.00035 20.5 0.4 0.00051 20.0 0.4 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_24 PF13412.6 AIF84711.1 - 0.0012 18.4 0.0 0.0027 17.2 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 AIF84711.1 - 0.0025 17.7 0.0 0.0041 17.0 0.0 1.4 1 0 0 1 1 1 1 HTH domain Dimerisation2 PF16864.5 AIF84711.1 - 0.02 14.8 0.0 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 Dimerisation domain MarR_2 PF12802.7 AIF84711.1 - 0.021 14.7 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 MarR family Phage_rep_org_N PF09681.10 AIF84711.1 - 0.03 14.2 0.1 0.039 13.9 0.1 1.2 1 0 0 1 1 1 0 N-terminal phage replisome organiser (Phage_rep_org_N) Nup35_RRM PF05172.13 AIF84711.1 - 0.042 13.8 0.0 0.06 13.3 0.0 1.2 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif B-block_TFIIIC PF04182.12 AIF84711.1 - 0.088 13.0 0.0 0.58 10.4 0.0 2.0 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC LexA_DNA_bind PF01726.16 AIF84711.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 LexA DNA binding domain Penicillinase_R PF03965.16 AIF84711.1 - 0.14 12.5 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 Penicillinase repressor DUF3179 PF11376.8 AIF84713.1 - 8.8e-104 346.9 0.0 1.1e-103 346.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3179) LapA_dom PF06305.11 AIF84714.1 - 0.1 12.4 0.2 0.13 12.1 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Mito_carr PF00153.27 AIF84715.1 - 8.5 6.4 14.4 0.33 10.9 0.4 3.6 3 1 1 4 4 4 0 Mitochondrial carrier protein DUF1887 PF09002.11 AIF84716.1 - 0.015 14.0 0.1 0.022 13.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1887) DUF997 PF06196.12 AIF84717.1 - 1.2 9.2 4.8 3.7 7.6 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF997) HTH_10 PF04967.12 AIF84718.1 - 1.3e-17 63.3 0.1 2.2e-17 62.6 0.1 1.4 1 0 0 1 1 1 1 HTH DNA binding domain HTH_5 PF01022.20 AIF84718.1 - 0.017 15.0 0.2 0.052 13.4 0.2 1.8 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 AIF84718.1 - 0.084 12.8 0.1 0.25 11.3 0.1 1.8 1 0 0 1 1 1 0 MarR family Sigma70_r4_2 PF08281.12 AIF84718.1 - 0.12 12.0 1.2 1.2 8.8 1.2 2.2 1 1 0 1 1 1 0 Sigma-70, region 4 MerB PF03243.15 AIF84719.1 - 1.6e-32 112.3 0.0 2.3e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 Alkylmercury lyase HTH_15 PF12324.8 AIF84719.1 - 2.5e-05 24.1 0.0 4.3e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of alkylmercury lyase HTH_45 PF14947.6 AIF84723.1 - 1.3e-19 69.9 1.2 1.6e-19 69.7 1.2 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIF84723.1 - 1.5e-05 24.8 0.1 1.9e-05 24.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_27 PF13463.6 AIF84723.1 - 0.00079 19.9 0.0 0.0013 19.2 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HxlR PF01638.17 AIF84723.1 - 0.0096 15.8 0.1 0.011 15.6 0.1 1.2 1 0 0 1 1 1 1 HxlR-like helix-turn-helix RQC PF09382.10 AIF84723.1 - 0.013 15.3 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 RQC domain Homeobox_KN PF05920.11 AIF84723.1 - 0.068 13.1 0.0 6.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Homeobox KN domain DUF4363 PF14276.6 AIF84724.1 - 0.033 14.3 0.3 2.9 8.1 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) EzrA PF06160.12 AIF84724.1 - 0.033 12.4 2.1 3 5.9 0.1 2.4 3 0 0 3 3 3 0 Septation ring formation regulator, EzrA PhoU PF01895.19 AIF84724.1 - 0.045 14.2 3.9 0.24 11.9 0.2 2.8 2 1 0 2 2 2 0 PhoU domain UPF0184 PF03670.13 AIF84724.1 - 0.065 13.6 1.9 1.9 8.9 0.0 3.2 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) SR-25 PF10500.9 AIF84724.1 - 5.1 6.6 17.9 0.19 11.3 11.4 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF2167 PF09935.9 AIF84725.1 - 0.066 12.4 0.0 0.097 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) HhH-GPD PF00730.25 AIF84726.1 - 1.4e-27 96.2 0.0 2.1e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 AIF84726.1 - 3.7e-09 36.0 0.2 6e-08 32.2 0.0 2.9 2 1 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 AIF84726.1 - 6.7e-07 29.8 0.2 0.046 14.3 0.1 2.8 2 1 1 3 3 3 2 Helix-hairpin-helix domain DUF2400 PF09674.10 AIF84726.1 - 0.0094 16.0 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2400) HHH_2 PF12826.7 AIF84726.1 - 0.016 15.3 0.0 1.6 8.9 0.0 2.5 1 1 1 2 2 2 0 Helix-hairpin-helix motif AGOG PF09171.10 AIF84726.1 - 0.15 11.4 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 N-glycosylase/DNA lyase DUF521 PF04412.13 AIF84727.1 - 1.7e-117 392.6 0.1 2.1e-117 392.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF521) DUF126 PF01989.16 AIF84728.1 - 1.5e-28 98.4 0.1 2.2e-28 97.8 0.1 1.3 1 0 0 1 1 1 1 Aconitase X swivel domain TF_Zn_Ribbon PF08271.12 AIF84729.1 - 9.9e-08 31.4 0.2 1.4e-07 30.9 0.2 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 AIF84729.1 - 0.00022 21.1 0.2 0.00044 20.1 0.2 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf_Rg PF17915.1 AIF84729.1 - 0.0006 19.2 0.2 0.00072 18.9 0.2 1.2 1 0 0 1 1 1 1 Reverse gyrase zinc finger zinc-ribbons_6 PF07191.12 AIF84729.1 - 0.0019 18.1 0.6 0.003 17.5 0.6 1.3 1 0 0 1 1 1 1 zinc-ribbons Zn-ribbon_8 PF09723.10 AIF84729.1 - 0.0075 16.4 0.4 2.1 8.5 0.0 2.5 2 0 0 2 2 2 1 Zinc ribbon domain Zn_Tnp_IS91 PF14319.6 AIF84729.1 - 0.0078 16.2 0.1 0.013 15.6 0.1 1.4 1 1 0 1 1 1 1 Transposase zinc-binding domain zf-ribbon_3 PF13248.6 AIF84729.1 - 0.017 14.5 1.3 1.6 8.2 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 AIF84729.1 - 0.019 14.9 0.4 0.028 14.4 0.4 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF2318 PF10080.9 AIF84729.1 - 0.035 14.2 0.1 0.035 14.2 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Lar_restr_allev PF14354.6 AIF84729.1 - 0.039 14.3 1.2 0.076 13.4 1.2 1.6 1 1 0 1 1 1 0 Restriction alleviation protein Lar Zn_ribbon_SprT PF17283.2 AIF84729.1 - 0.055 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 SprT-like zinc ribbon domain zf-IS66 PF13005.7 AIF84729.1 - 0.068 13.6 0.7 1.5 9.3 0.1 2.2 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 Nudix_N_2 PF14803.6 AIF84729.1 - 0.074 13.0 3.8 0.72 9.8 3.8 2.1 1 1 0 1 1 1 0 Nudix N-terminal PADR1 PF08063.12 AIF84729.1 - 0.092 12.5 1.6 0.14 12.0 1.6 1.3 1 0 0 1 1 1 0 PADR1 (NUC008) domain DZR PF12773.7 AIF84729.1 - 0.15 12.1 2.0 0.42 10.7 2.0 1.7 1 1 0 1 1 1 0 Double zinc ribbon Prim_Zn_Ribbon PF08273.12 AIF84729.1 - 0.2 12.0 3.1 0.6 10.4 3.1 1.8 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase ATP_bind_3 PF01171.20 AIF84730.1 - 4.7e-20 72.1 0.0 6.7e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 PP-loop family NAD_synthase PF02540.17 AIF84730.1 - 0.005 16.0 0.1 0.0071 15.5 0.1 1.1 1 0 0 1 1 1 1 NAD synthase tRNA_Me_trans PF03054.16 AIF84730.1 - 0.037 12.8 0.0 0.055 12.3 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase CTU2 PF10288.9 AIF84730.1 - 0.039 14.2 2.9 0.11 12.8 0.1 2.7 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 C1_2 PF03107.16 AIF84730.1 - 2.9 8.3 14.6 1.1 9.7 1.5 3.4 3 0 0 3 3 3 0 C1 domain TF_Zn_Ribbon PF08271.12 AIF84730.1 - 7 6.3 14.5 0.11 12.0 1.2 3.8 5 0 0 5 5 5 0 TFIIB zinc-binding Prenyltrans PF00432.21 AIF84731.1 - 0.24 11.2 3.3 0.66 9.8 3.3 1.8 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat Metallothio_Pro PF02069.16 AIF84732.1 - 0.00029 21.0 0.1 0.00045 20.4 0.1 1.3 1 0 0 1 1 1 1 Prokaryotic metallothionein DUF2116 PF09889.9 AIF84732.1 - 0.022 14.7 1.2 0.057 13.4 1.2 1.7 1 1 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) zf-CpG_bind_C PF12269.8 AIF84732.1 - 0.025 14.4 0.2 0.027 14.2 0.2 1.0 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain YHS PF04945.13 AIF84732.1 - 0.049 13.7 3.9 0.2 11.8 2.3 2.3 2 1 0 2 2 2 0 YHS domain DUF202 PF02656.15 AIF84734.1 - 1.8 9.1 4.0 0.57 10.7 0.4 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF202) MitoNEET_N PF10660.9 AIF84735.1 - 0.0083 16.1 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Iron-containing outer mitochondrial membrane protein N-terminus DUF4366 PF14283.6 AIF84735.1 - 0.14 12.2 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) SGL PF08450.12 AIF84736.1 - 8.9e-10 38.6 0.1 0.17 11.5 0.0 5.1 1 1 5 6 6 6 5 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 AIF84736.1 - 0.00062 19.7 0.4 0.065 13.3 0.0 3.6 4 0 0 4 4 4 1 NHL repeat Str_synth PF03088.16 AIF84736.1 - 0.034 14.3 0.0 5.4 7.2 0.0 3.9 4 0 0 4 4 4 0 Strictosidine synthase PepSY PF03413.19 AIF84737.1 - 0.028 15.0 0.1 0.043 14.4 0.1 1.4 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain E1-E2_ATPase PF00122.20 AIF84738.1 - 1.5e-56 190.8 1.4 1.5e-56 190.8 1.4 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AIF84738.1 - 1.7e-51 175.5 4.3 1.7e-51 175.5 4.3 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase YHS PF04945.13 AIF84738.1 - 4.1e-09 36.4 0.3 7.6e-09 35.5 0.3 1.4 1 0 0 1 1 1 1 YHS domain Hydrolase_3 PF08282.12 AIF84738.1 - 5e-07 29.7 1.6 0.0083 15.9 0.3 2.3 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 AIF84738.1 - 9.7e-06 26.1 0.0 4.7e-05 23.9 0.1 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 AIF84738.1 - 0.0033 17.5 0.0 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Ntox34 PF15606.6 AIF84738.1 - 0.0055 16.8 0.8 0.011 15.9 0.2 1.8 2 0 0 2 2 2 1 Bacterial toxin 34 PIN_9 PF18477.1 AIF84738.1 - 0.0063 16.8 1.0 0.013 15.8 0.1 2.0 2 0 0 2 2 2 1 PIN like domain ADH_zinc_N PF00107.26 AIF84738.1 - 0.0085 16.1 2.3 0.058 13.4 0.1 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase NosL PF05573.12 AIF84738.1 - 0.085 13.2 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 NosL DUF2116 PF09889.9 AIF84738.1 - 0.092 12.7 0.0 0.54 10.3 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF1449 PF07290.11 AIF84738.1 - 1.5 8.4 8.0 5.2 6.6 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1449) HMA PF00403.26 AIF84739.1 - 1.2e-11 44.9 0.1 1.5e-11 44.6 0.1 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain ChlI PF13541.6 AIF84739.1 - 0.1 12.4 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Subunit ChlI of Mg-chelatase YHS PF04945.13 AIF84740.1 - 3.6e-12 46.2 0.2 4.1e-12 46.0 0.2 1.0 1 0 0 1 1 1 1 YHS domain DEAD PF00270.29 AIF84743.1 - 1.1e-52 178.3 0.0 1.3e-51 174.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AIF84743.1 - 1.1e-33 115.9 0.1 8.3e-33 113.1 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AIF84743.1 - 1.8e-05 24.8 0.0 4.1e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AIF84743.1 - 6.9e-05 22.2 0.0 0.00011 21.6 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase UTP25 PF06862.12 AIF84743.1 - 9.3e-05 21.4 0.0 0.23 10.2 0.0 2.8 2 1 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_30 PF13604.6 AIF84743.1 - 0.00013 21.7 0.3 0.4 10.4 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 AIF84743.1 - 0.022 15.1 0.1 1.9 8.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain CMS1 PF14617.6 AIF84743.1 - 0.055 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Fer4_7 PF12838.7 AIF84744.1 - 2.4e-10 40.8 12.8 5.6e-07 30.1 7.8 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 AIF84744.1 - 5.2e-09 35.6 11.4 4.1e-07 29.6 2.0 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 AIF84744.1 - 2.9e-07 30.5 4.7 5e-07 29.7 4.7 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 AIF84744.1 - 3.2e-07 30.4 5.0 4.5e-07 29.9 5.0 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIF84744.1 - 6e-06 26.6 1.1 0.067 13.6 0.6 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIF84744.1 - 5.8e-05 23.1 7.5 0.0015 18.6 7.9 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIF84744.1 - 6.6e-05 22.8 12.0 0.00027 20.9 1.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 AIF84744.1 - 0.00025 21.5 5.7 0.32 11.6 2.8 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIF84744.1 - 0.00025 21.9 6.5 0.24 12.4 0.1 2.3 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain ETF_QO PF05187.13 AIF84744.1 - 0.00031 20.8 0.1 0.00034 20.7 0.1 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Tenui_PVC2 PF06656.11 AIF84744.1 - 0.00097 17.2 0.1 0.001 17.1 0.1 1.0 1 0 0 1 1 1 1 Tenuivirus PVC2 protein Fer4_15 PF13459.6 AIF84744.1 - 0.0041 17.8 1.9 0.0041 17.8 1.9 2.2 1 1 1 2 2 2 1 4Fe-4S single cluster domain Fer4_22 PF17179.4 AIF84744.1 - 0.0085 16.9 2.5 0.44 11.4 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIF84744.1 - 0.012 16.5 11.1 0.44 11.6 0.6 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_13 PF13370.6 AIF84744.1 - 0.012 16.1 0.7 0.012 16.1 0.7 2.2 1 1 1 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_2 PF12797.7 AIF84744.1 - 0.013 15.5 10.6 0.031 14.4 0.8 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_4 PF12800.7 AIF84744.1 - 0.15 12.7 9.5 0.32 11.6 0.2 2.4 2 1 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 AIF84744.1 - 0.28 11.4 6.9 0.7 10.1 0.5 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain Diphthamide_syn PF01866.17 AIF84745.1 - 5.2e-60 203.5 0.0 6.6e-60 203.1 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein UbiD PF01977.16 AIF84748.1 - 1.6e-94 317.1 0.4 1.8e-94 316.9 0.4 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Mlf1IP PF10248.9 AIF84748.1 - 0.039 13.9 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein rRNA_processing PF08524.11 AIF84749.1 - 0.041 13.9 0.5 0.044 13.8 0.5 1.0 1 0 0 1 1 1 0 rRNA processing DUF218 PF02698.17 AIF84750.1 - 0.11 12.6 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 DUF218 domain Herpes_glycoH_C PF17488.2 AIF84751.1 - 0.045 13.5 0.7 0.068 13.0 0.7 1.3 1 0 0 1 1 1 0 Herpesvirus glycoprotein H C-terminal domain TFIIB PF00382.19 AIF84752.1 - 1.4e-31 108.3 0.8 1.4e-15 57.0 0.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Sigma70_r4 PF04545.16 AIF84752.1 - 3.3e-06 26.5 0.1 9.2e-05 21.9 0.1 2.8 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_AsnC-type PF13404.6 AIF84752.1 - 0.0012 18.6 2.2 0.075 12.9 0.1 3.2 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain Cyclin_N PF00134.23 AIF84752.1 - 0.0073 16.1 0.0 0.067 12.9 0.0 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain T3SS_LEE_assoc PF13327.6 AIF84752.1 - 0.011 15.7 0.1 0.38 10.8 0.0 2.2 1 1 1 2 2 2 0 Type III secretion system subunit Cyclin_C PF02984.19 AIF84752.1 - 0.015 15.4 0.0 8.1 6.6 0.0 2.2 2 0 0 2 2 2 0 Cyclin, C-terminal domain RB_B PF01857.20 AIF84752.1 - 0.048 13.7 0.0 0.12 12.5 0.0 1.6 2 0 0 2 2 2 0 Retinoblastoma-associated protein B domain Rrf2 PF02082.20 AIF84752.1 - 0.053 13.9 0.2 20 5.6 0.0 3.4 1 1 2 3 3 3 0 Transcriptional regulator HTH_Tnp_ISL3 PF13542.6 AIF84752.1 - 0.085 12.3 0.1 4.7 6.7 0.1 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_24 PF13412.6 AIF84752.1 - 0.091 12.3 0.1 0.46 10.1 0.1 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Sigma70_r4_2 PF08281.12 AIF84752.1 - 0.18 11.5 0.1 0.18 11.5 0.1 2.6 4 0 0 4 4 4 0 Sigma-70, region 4 HTH_IclR PF09339.10 AIF84752.1 - 0.21 11.4 0.5 2.5 8.0 0.0 2.7 3 0 0 3 3 3 0 IclR helix-turn-helix domain ABM PF03992.16 AIF84753.1 - 3e-05 24.0 0.0 4.2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF4149 PF13664.6 AIF84753.1 - 0.041 14.2 1.9 0.071 13.4 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) HxlR PF01638.17 AIF84754.1 - 2.8e-24 84.8 0.1 3.5e-24 84.5 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.14 AIF84754.1 - 0.16 12.0 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family EutH PF04346.12 AIF84755.1 - 0.018 14.2 2.7 0.02 14.1 2.7 1.1 1 0 0 1 1 1 0 Ethanolamine utilisation protein, EutH DUF3487 PF11990.8 AIF84755.1 - 2.8 7.8 9.5 3.3 7.6 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) LEA_2 PF03168.13 AIF84756.1 - 0.0016 18.9 0.0 0.0048 17.4 0.0 1.8 1 1 0 1 1 1 1 Late embryogenesis abundant protein CopD PF05425.13 AIF84757.1 - 1.4e-13 51.2 6.0 1.4e-13 51.2 6.0 1.6 2 0 0 2 2 2 1 Copper resistance protein D DUF4149 PF13664.6 AIF84757.1 - 0.0029 17.9 0.4 0.0029 17.9 0.4 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) DUF1035 PF06281.12 AIF84757.1 - 0.012 15.5 0.5 0.012 15.5 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1035) Urate_ox_N PF06181.11 AIF84757.1 - 0.048 13.0 0.2 0.048 13.0 0.2 2.1 2 0 0 2 2 2 0 Urate oxidase N-terminal DUF1772 PF08592.11 AIF84757.1 - 0.066 13.5 1.7 0.098 13.0 1.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) DUF2269 PF10027.9 AIF84757.1 - 0.51 10.4 8.7 0.66 10.0 8.7 1.2 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) RTC PF01137.21 AIF84758.1 - 1.2e-70 237.2 0.0 1.6e-70 236.8 0.0 1.2 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 AIF84758.1 - 4.3e-11 43.2 0.1 9.1e-11 42.2 0.1 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Bac_luciferase PF00296.20 AIF84759.1 - 1.1e-55 189.3 0.0 1.3e-55 189.1 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase CTP_transf_like PF01467.26 AIF84760.1 - 1.1e-15 58.1 0.1 2.2e-15 57.1 0.1 1.7 1 1 0 1 1 1 1 Cytidylyltransferase-like HIGH_NTase1 PF05636.11 AIF84760.1 - 0.068 12.4 0.0 0.85 8.8 0.0 2.0 2 0 0 2 2 2 0 HIGH Nucleotidyl Transferase Asparaginase PF00710.20 AIF84763.1 - 2.1e-59 200.3 0.4 4.3e-59 199.3 0.4 1.5 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 AIF84763.1 - 7.8e-28 97.0 0.0 2.4e-27 95.4 0.0 1.8 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain GatD_N PF18195.1 AIF84763.1 - 8.4e-17 60.2 0.3 1.8e-16 59.2 0.3 1.6 1 0 0 1 1 1 1 GatD N-terminal domain GatB_N PF02934.15 AIF84764.1 - 3.2e-63 213.7 0.0 4e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 AIF84764.1 - 1.3e-19 70.6 2.5 1.3e-19 70.6 2.5 1.9 2 0 0 2 2 2 1 GatB domain GAD PF02938.14 AIF84764.1 - 2.2e-07 31.0 0.0 6.7e-07 29.5 0.0 1.9 1 0 0 1 1 1 1 GAD domain YqeY PF09424.10 AIF84764.1 - 0.0012 18.9 0.8 0.0012 18.9 0.8 2.0 2 0 0 2 2 2 1 Yqey-like protein Amdase PF17645.1 AIF84764.1 - 0.046 13.4 0.2 0.17 11.5 0.2 1.9 2 0 0 2 2 2 0 Arylmalonate decarboxylase DUF5405 PF17399.2 AIF84765.1 - 0.061 13.6 0.1 0.1 12.9 0.1 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5405) CPBP PF02517.16 AIF84766.1 - 1.8e-05 25.0 5.1 1.8e-05 25.0 5.1 1.7 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease Gram_pos_anchor PF00746.21 AIF84766.1 - 0.052 13.5 0.2 0.052 13.5 0.2 2.0 2 0 0 2 2 2 0 LPXTG cell wall anchor motif MarR_2 PF12802.7 AIF84767.1 - 0.0071 16.2 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 MarR family HTH_45 PF14947.6 AIF84767.1 - 0.0098 15.9 0.0 0.029 14.4 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn-helix HTH_34 PF13601.6 AIF84767.1 - 0.015 15.5 0.0 0.16 12.2 0.0 2.2 2 0 0 2 2 2 0 Winged helix DNA-binding domain Rio2_N PF09202.11 AIF84767.1 - 0.029 14.6 0.0 0.063 13.5 0.0 1.6 1 1 0 1 1 1 0 Rio2, N-terminal HTH_27 PF13463.6 AIF84767.1 - 0.056 14.0 0.1 0.12 12.9 0.0 1.7 2 0 0 2 2 2 0 Winged helix DNA-binding domain TrmB PF01978.19 AIF84767.1 - 0.057 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 AIF84767.1 - 0.072 13.0 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 MarR family TcpS PF17456.2 AIF84768.1 - 0.0011 19.1 0.0 0.0014 18.7 0.0 1.1 1 0 0 1 1 1 1 Toxin-coregulated pilus protein S DUF1579 PF07617.11 AIF84768.1 - 0.08 12.9 0.1 0.24 11.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1579) DDE_Tnp_ISAZ013 PF07592.11 AIF84768.1 - 0.089 11.8 0.1 11 4.9 0.0 2.1 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain NurA PF09376.10 AIF84769.1 - 2.4e-05 24.2 0.3 0.00023 21.0 0.2 2.0 1 1 1 2 2 2 1 NurA domain DUF3475 PF11961.8 AIF84769.1 - 0.16 12.1 1.2 0.54 10.4 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3475) DUF87 PF01935.17 AIF84770.1 - 8.3e-08 32.6 0.0 3.1e-07 30.7 0.0 2.0 1 1 0 1 1 1 1 Helicase HerA, central domain AAA_22 PF13401.6 AIF84770.1 - 0.0014 18.9 0.0 0.18 12.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain CLP1_P PF16575.5 AIF84770.1 - 0.022 14.5 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RRM_occluded PF16842.5 AIF84770.1 - 0.031 14.1 0.0 0.094 12.6 0.0 1.9 1 0 0 1 1 1 0 Occluded RNA-recognition motif CbiA PF01656.23 AIF84770.1 - 0.1 12.7 0.0 0.15 12.1 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_14 PF13173.6 AIF84770.1 - 0.12 12.4 0.1 0.44 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain P-II PF00543.22 AIF84771.1 - 5.8e-22 78.2 1.0 6.9e-22 78.0 1.0 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II LTD PF00932.19 AIF84772.1 - 8.4e-16 58.3 1.7 9.1e-16 58.2 0.5 1.6 2 0 0 2 2 2 1 Lamin Tail Domain SNase PF00565.17 AIF84772.1 - 0.0018 18.7 0.0 0.0037 17.7 0.0 1.5 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Phage_holin_3_6 PF07332.11 AIF84773.1 - 0.049 13.7 11.6 0.054 13.5 11.6 1.0 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Sensor PF13796.6 AIF84773.1 - 0.11 12.5 7.5 0.12 12.4 7.5 1.0 1 0 0 1 1 1 0 Putative sensor DUF4175 PF13779.6 AIF84773.1 - 0.31 8.9 4.8 0.32 8.9 4.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) OST3_OST6 PF04756.13 AIF84773.1 - 0.34 10.2 2.1 0.38 10.1 2.1 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family DUF3093 PF11292.8 AIF84773.1 - 0.7 10.2 6.0 0.83 9.9 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) Glycos_transf_4 PF00953.21 AIF84774.1 - 3.3e-27 95.4 16.2 3.3e-27 95.4 16.2 2.2 3 0 0 3 3 3 1 Glycosyl transferase family 4 DEAD PF00270.29 AIF84775.1 - 4.2e-24 85.3 0.0 1e-23 84.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AIF84775.1 - 6.9e-10 39.3 0.0 7.8e-09 35.9 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.6 AIF84775.1 - 8.4e-10 39.1 3.6 1.1e-09 38.8 0.7 2.7 3 0 0 3 3 3 1 Helix-hairpin-helix domain ResIII PF04851.15 AIF84775.1 - 2e-06 27.9 0.0 1.9e-05 24.7 0.0 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit HHH PF00633.23 AIF84775.1 - 0.00035 20.3 1.4 0.24 11.3 0.0 3.4 3 0 0 3 3 3 2 Helix-hairpin-helix motif HHH_2 PF12826.7 AIF84775.1 - 0.0035 17.4 0.0 0.011 15.8 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif DNA_pol_lambd_f PF10391.9 AIF84775.1 - 0.0091 15.8 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda ATPase_2 PF01637.18 AIF84775.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 AIF84775.1 - 0.12 11.5 0.1 0.2 10.7 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF4157 PF13699.6 AIF84776.1 - 0.0066 16.7 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4157) MCM PF00493.23 AIF84777.1 - 5e-93 310.3 0.0 7.3e-93 309.8 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AIF84777.1 - 1.2e-36 125.3 0.1 2.1e-36 124.6 0.1 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AIF84777.1 - 3.2e-22 78.8 0.2 5.9e-22 77.9 0.2 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AIF84777.1 - 2.5e-15 56.9 1.6 5.1e-15 55.9 0.8 1.9 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 AIF84777.1 - 1.4e-06 27.9 0.1 0.00028 20.3 0.0 2.5 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AIF84777.1 - 2.1e-06 27.8 0.0 1.2e-05 25.3 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 AIF84777.1 - 0.0014 18.5 0.0 0.0052 16.6 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AIF84777.1 - 0.061 13.7 0.3 1.4 9.3 0.0 2.8 2 1 1 3 3 3 0 AAA ATPase domain AAA_30 PF13604.6 AIF84777.1 - 0.066 12.9 0.6 0.36 10.5 0.3 2.4 2 0 0 2 2 2 0 AAA domain Zn-ribbon_8 PF09723.10 AIF84777.1 - 0.12 12.5 0.4 0.25 11.5 0.4 1.5 1 0 0 1 1 1 0 Zinc ribbon domain AAA PF00004.29 AIF84777.1 - 0.14 12.6 0.0 0.39 11.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sld5 PF05916.11 AIF84778.1 - 3.1e-06 27.6 0.1 5.4e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 GINS complex protein Porin_5 PF16930.5 AIF84778.1 - 0.027 13.0 0.1 0.027 13.0 0.1 1.1 1 0 0 1 1 1 0 Putative porin DNA_pol3_delta2 PF13177.6 AIF84779.1 - 1.7e-15 57.2 0.1 1.2e-13 51.1 0.1 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 AIF84779.1 - 7.9e-14 52.2 0.0 1.4e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 AIF84779.1 - 4.9e-08 33.3 0.8 1.7e-07 31.5 0.0 2.4 3 0 0 3 3 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 AIF84779.1 - 1.2e-07 31.8 0.0 2.5e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 AIF84779.1 - 7.1e-06 25.9 0.1 3e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 AIF84779.1 - 1.5e-05 25.1 0.0 3.2e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AIF84779.1 - 8.3e-05 22.9 0.2 0.0042 17.4 0.2 2.6 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 AIF84779.1 - 0.00014 21.9 0.0 0.00096 19.2 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_16 PF13191.6 AIF84779.1 - 0.00015 22.2 0.0 0.0016 18.9 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain DEAD PF00270.29 AIF84779.1 - 0.00016 21.5 0.2 0.08 12.7 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase AAA_24 PF13479.6 AIF84779.1 - 0.0006 19.6 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 AIF84779.1 - 0.003 17.8 0.0 0.0076 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain Mg_chelatase PF01078.21 AIF84779.1 - 0.003 16.9 0.0 0.7 9.2 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MeaB PF03308.16 AIF84779.1 - 0.0033 16.4 0.1 0.013 14.5 0.0 1.8 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 AIF84779.1 - 0.0051 16.8 0.0 0.038 13.9 0.0 2.0 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 AIF84779.1 - 0.0061 16.3 0.0 0.019 14.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AIF84779.1 - 0.011 16.0 0.3 0.92 9.8 0.0 2.4 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.22 AIF84779.1 - 0.011 14.9 0.0 0.027 13.7 0.0 1.7 1 1 0 1 1 1 0 NB-ARC domain AAA_2 PF07724.14 AIF84779.1 - 0.014 15.5 0.0 0.038 14.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 AIF84779.1 - 0.02 14.6 0.1 0.26 11.0 0.1 2.4 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 AIF84779.1 - 0.033 14.2 0.2 0.12 12.4 0.2 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 AIF84779.1 - 0.038 13.9 0.5 2.1 8.3 0.0 2.2 1 1 1 2 2 2 0 NTPase DNA_pol3_delta PF06144.13 AIF84779.1 - 0.067 13.0 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_18 PF13238.6 AIF84779.1 - 0.11 13.0 0.0 0.23 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 AIF84779.1 - 0.11 11.6 0.0 0.22 10.6 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 AIF84779.1 - 0.14 11.6 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 AIF84779.1 - 0.2 11.4 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase zinc_ribbon_10 PF10058.9 AIF84780.1 - 0.0002 21.0 0.2 0.00036 20.2 0.2 1.4 1 1 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein zinc_ribbon_4 PF13717.6 AIF84780.1 - 0.00064 19.6 0.4 0.19 11.7 0.2 2.2 2 0 0 2 2 2 1 zinc-ribbon domain CpXC PF14353.6 AIF84780.1 - 0.0041 17.1 1.2 0.15 12.1 0.1 2.2 1 1 1 2 2 2 1 CpXC protein C1_1 PF00130.22 AIF84780.1 - 0.0099 15.7 0.3 0.015 15.1 0.3 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) OrfB_Zn_ribbon PF07282.11 AIF84780.1 - 0.014 15.3 0.1 0.03 14.2 0.1 1.5 1 1 0 1 1 1 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 AIF84780.1 - 0.017 14.5 0.4 0.91 9.0 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain tRNA-synt_1f PF01921.18 AIF84780.1 - 0.019 13.9 0.0 0.023 13.6 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (K) HypA PF01155.19 AIF84780.1 - 0.024 14.7 0.6 0.034 14.2 0.4 1.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-H2C2_2 PF13465.6 AIF84780.1 - 0.029 14.8 1.3 3.8 8.1 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double domain Zn-ribbon_8 PF09723.10 AIF84780.1 - 0.031 14.4 0.8 0.031 14.4 0.8 1.9 2 0 0 2 2 2 0 Zinc ribbon domain Mu-like_Com PF10122.9 AIF84780.1 - 0.041 13.3 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 Mu-like prophage protein Com zf-C2H2_12 PF18658.1 AIF84780.1 - 0.079 12.6 0.1 0.19 11.3 0.1 1.6 1 1 1 2 2 2 0 Zinc-finger C2H2-type zf-C2H2 PF00096.26 AIF84780.1 - 0.081 13.4 1.0 18 6.0 0.2 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Prim_Zn_Ribbon PF08273.12 AIF84780.1 - 0.083 13.2 1.2 7.8 6.9 0.2 2.2 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase zf-C2H2_6 PF13912.6 AIF84780.1 - 0.091 12.8 3.9 5.7 7.1 1.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger TFIIS_C PF01096.18 AIF84780.1 - 0.1 12.4 2.2 4.6 7.2 0.2 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Elf1 PF05129.13 AIF84780.1 - 0.11 12.6 1.4 14 5.8 0.1 1.8 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like TF_Zn_Ribbon PF08271.12 AIF84780.1 - 0.21 11.1 7.6 2.4 7.7 0.5 2.8 1 1 2 3 3 3 0 TFIIB zinc-binding zf-C2H2_4 PF13894.6 AIF84780.1 - 0.36 11.8 2.1 24 6.1 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zinc_ribbon_5 PF13719.6 AIF84780.1 - 0.39 10.5 3.3 0.85 9.4 0.9 2.3 2 1 0 2 2 2 0 zinc-ribbon domain Pirin PF02678.16 AIF84781.1 - 5.8e-38 129.2 0.3 5.1e-37 126.2 0.1 2.1 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 AIF84781.1 - 1.6e-34 118.4 0.0 8.9e-33 112.8 0.0 2.9 3 0 0 3 3 3 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 AIF84781.1 - 9.3e-09 34.9 2.6 0.0016 18.1 0.1 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 AIF84781.1 - 0.0031 17.2 0.7 0.24 11.1 0.1 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF861) AraC_binding PF02311.19 AIF84781.1 - 0.12 12.3 0.0 11 5.9 0.0 2.2 2 0 0 2 2 2 0 AraC-like ligand binding domain Patatin PF01734.22 AIF84782.1 - 2.2e-26 93.3 0.0 3.4e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase DUF3734 PF12536.8 AIF84782.1 - 4.8e-06 26.9 0.8 2.9e-05 24.4 0.8 2.1 1 1 0 1 1 1 1 Patatin phospholipase PWWP PF00855.17 AIF84782.1 - 0.041 14.3 0.0 0.099 13.1 0.0 1.7 1 0 0 1 1 1 0 PWWP domain DUF202 PF02656.15 AIF84783.1 - 0.045 14.2 0.7 0.045 14.2 0.7 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF202) Phage_holin_3_6 PF07332.11 AIF84783.1 - 0.046 13.8 0.2 0.046 13.8 0.2 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Stimulus_sens_1 PF13756.6 AIF84783.1 - 0.2 12.3 0.0 0.29 11.7 0.0 1.2 1 0 0 1 1 1 0 Stimulus-sensing domain ATP1G1_PLM_MAT8 PF02038.16 AIF84783.1 - 0.21 11.0 0.2 0.21 11.0 0.2 2.0 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family LapA_dom PF06305.11 AIF84783.1 - 1.1 9.1 5.6 2.3 8.1 0.1 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Phage_holin_2_4 PF16082.5 AIF84783.1 - 1.7 8.5 4.0 4.5 7.1 0.3 2.2 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like FTR1 PF03239.14 AIF84784.1 - 2.4e-17 63.1 23.7 3.2e-16 59.4 20.0 3.3 2 1 0 2 2 2 1 Iron permease FTR1 family Lactonase PF10282.9 AIF84785.1 - 1.2e-08 34.6 1.1 8.8e-06 25.2 0.2 2.2 1 1 0 2 2 2 2 Lactonase, 7-bladed beta-propeller NHL PF01436.21 AIF84785.1 - 6.1e-08 32.3 20.2 0.17 12.0 0.1 7.5 6 1 1 7 7 7 3 NHL repeat Cytochrom_D1 PF02239.16 AIF84785.1 - 3.8e-05 22.4 2.0 0.011 14.3 0.1 2.3 1 1 1 2 2 2 2 Cytochrome D1 heme domain SGL PF08450.12 AIF84785.1 - 6.4e-05 22.6 3.4 0.00096 18.8 3.4 2.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 AIF84785.1 - 0.0023 18.1 13.0 1.6 9.0 0.2 5.2 2 1 4 6 6 6 2 Arylesterase Glu_cyclase_2 PF05096.12 AIF84785.1 - 0.016 14.7 1.2 2.7 7.3 0.0 2.9 1 1 2 3 3 3 0 Glutamine cyclotransferase Img2 PF05046.14 AIF84785.1 - 0.082 13.2 2.1 48 4.4 0.0 4.5 1 1 2 3 3 3 0 Mitochondrial large subunit ribosomal protein (Img2) Cyd_oper_YbgE PF09600.10 AIF84785.1 - 0.11 12.9 0.3 0.2 12.0 0.3 1.3 1 0 0 1 1 1 0 Cyd operon protein YbgE (Cyd_oper_YbgE) Trypan_PARP PF05887.11 AIF84785.1 - 0.11 12.4 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) E2F_CC-MB PF16421.5 AIF84785.1 - 0.17 12.2 0.1 1.3 9.4 0.0 2.1 1 1 1 2 2 2 0 E2F transcription factor CC-MB domain 2C_adapt PF08793.10 AIF84785.1 - 0.34 11.1 12.8 46 4.3 0.0 5.6 6 0 0 6 6 6 0 2-cysteine adaptor domain PBP5_C PF07943.13 AIF84785.1 - 1.8 8.8 5.8 44 4.4 0.3 4.3 5 1 0 5 5 5 0 Penicillin-binding protein 5, C-terminal domain Ribosomal_S7 PF00177.21 AIF84787.1 - 1.2e-38 132.1 1.5 1.9e-38 131.4 1.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Ribosom_S12_S23 PF00164.25 AIF84788.1 - 9.2e-49 163.8 0.1 1.1e-48 163.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 KH_2 PF07650.17 AIF84789.1 - 3.5e-21 74.8 1.3 4.3e-14 52.1 0.1 2.2 2 0 0 2 2 2 2 KH domain KH_5 PF13184.6 AIF84789.1 - 1.5e-11 44.2 4.0 4.7e-10 39.4 0.3 2.2 2 0 0 2 2 2 2 NusA-like KH domain KH_4 PF13083.6 AIF84789.1 - 6.8e-11 41.9 1.5 0.00012 21.9 0.1 2.2 2 0 0 2 2 2 2 KH domain KH_1 PF00013.29 AIF84789.1 - 1.7e-08 34.1 0.6 4.5e-06 26.4 0.1 2.5 1 1 1 2 2 2 2 KH domain Polbeta PF18765.1 AIF84789.1 - 0.019 15.0 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Ribosomal_L7Ae PF01248.26 AIF84790.1 - 1.7e-10 40.5 1.6 2.1e-10 40.2 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF5615 PF18480.1 AIF84790.1 - 0.16 11.8 0.0 1.1 9.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5615) RNA_pol_Rpb1_1 PF04997.12 AIF84791.1 - 1.2e-94 317.1 0.0 2.4e-94 316.2 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 AIF84791.1 - 1.7e-86 290.0 0.8 3e-86 289.1 0.8 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 AIF84791.1 - 6.9e-73 244.3 0.0 1.5e-72 243.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 AIF84791.1 - 9.1e-32 110.2 0.0 2e-31 109.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 AIF84791.1 - 1.5e-24 86.0 0.0 3.5e-24 84.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Bystin PF05291.11 AIF84791.1 - 0.13 11.5 0.1 2 7.6 0.0 2.6 2 1 1 3 3 3 0 Bystin zf-RING_7 PF02591.15 AIF84791.1 - 0.17 12.1 0.5 26 5.1 0.1 2.9 2 0 0 2 2 2 0 C4-type zinc ribbon domain Fer4_17 PF13534.6 AIF84791.1 - 0.92 10.1 2.6 34 5.1 0.1 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain DUF35_N PF12172.8 AIF84791.1 - 8.1 6.4 6.9 93 3.0 0.1 3.5 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) RNA_pol_Rpb2_6 PF00562.28 AIF84792.1 - 6.2e-123 410.7 0.1 9.5e-123 410.1 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AIF84792.1 - 9.9e-47 159.1 0.0 1.8e-46 158.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 AIF84792.1 - 7.9e-33 112.7 0.4 1.7e-32 111.7 0.4 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 AIF84792.1 - 2.2e-28 98.2 0.1 4.5e-28 97.2 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 AIF84792.1 - 1.1e-21 77.4 0.0 2.1e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 AIF84792.1 - 7.4e-19 67.8 0.2 1.8e-18 66.6 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 AIF84792.1 - 3.7e-09 37.0 0.2 1e-08 35.6 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DUF2318 PF10080.9 AIF84792.1 - 0.03 14.4 0.4 0.065 13.4 0.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) FYVE PF01363.21 AIF84792.1 - 0.032 14.4 0.4 0.062 13.4 0.4 1.4 1 0 0 1 1 1 0 FYVE zinc finger FYVE_2 PF02318.16 AIF84792.1 - 0.094 12.9 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger Zn_Tnp_IS1595 PF12760.7 AIF84792.1 - 0.13 12.2 0.2 0.28 11.2 0.2 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIF84792.1 - 0.41 10.6 2.6 0.6 10.1 1.3 1.9 2 0 0 2 2 1 0 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 AIF84792.1 - 1.6 8.3 3.1 8.8 5.9 0.3 2.6 1 1 1 2 2 2 0 TFIIB zinc-binding RNA_pol_Rpb5_C PF01191.19 AIF84793.1 - 5.9e-28 96.5 0.6 6.8e-28 96.3 0.6 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain CDC48_N PF02359.18 AIF84793.1 - 0.063 13.5 0.0 0.089 13.0 0.0 1.4 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain MRP-S34 PF16053.5 AIF84793.1 - 0.076 12.7 0.1 0.094 12.4 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S34 MG2 PF01835.19 AIF84794.1 - 0.00099 19.5 0.2 0.0024 18.3 0.2 1.8 1 1 0 1 1 1 1 MG2 domain Ribosomal_S4e PF00900.20 AIF84794.1 - 0.04 13.8 0.0 0.2 11.6 0.0 2.1 2 0 0 2 2 2 0 Ribosomal family S4e Big_3 PF07523.12 AIF84794.1 - 0.047 14.0 0.3 0.047 14.0 0.3 3.3 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) NIF3 PF01784.18 AIF84795.1 - 1.2e-07 31.6 2.7 0.00088 19.0 0.1 2.1 1 1 1 2 2 2 2 NIF3 (NGG1p interacting factor 3) Glycos_transf_N PF04413.16 AIF84795.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) Wyosine_form PF08608.12 AIF84796.1 - 1.9e-19 69.8 0.0 5e-19 68.4 0.0 1.8 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 AIF84796.1 - 5.3e-17 62.7 0.1 2.1e-16 60.7 0.1 1.8 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 AIF84796.1 - 0.01 16.0 0.3 0.58 10.3 0.3 2.6 1 1 0 1 1 1 0 4Fe-4S single cluster domain Ham1p_like PF01725.16 AIF84797.1 - 5.5e-47 160.1 0.1 6.3e-47 159.9 0.1 1.0 1 0 0 1 1 1 1 Ham1 family APH PF01636.23 AIF84798.1 - 2.8e-10 40.6 0.7 2e-09 37.8 0.8 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 AIF84798.1 - 1.9e-08 34.0 0.1 1e-07 31.6 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain RIO1 PF01163.22 AIF84798.1 - 1.8e-07 30.9 0.0 2.8e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 AIF84798.1 - 2.5e-07 30.2 0.0 5.8e-07 29.1 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 AIF84798.1 - 6.5e-05 22.3 0.0 0.0001 21.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AIF84798.1 - 0.00032 20.1 0.0 0.00067 19.1 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 AIF84798.1 - 0.00088 18.9 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 AIF84798.1 - 0.0017 17.7 0.0 0.0026 17.1 0.0 1.4 1 1 0 1 1 1 1 Ecdysteroid kinase HipA_C PF07804.12 AIF84798.1 - 0.024 14.4 0.0 0.034 13.8 0.0 1.2 1 0 0 1 1 1 0 HipA-like C-terminal domain Fructosamin_kin PF03881.14 AIF84798.1 - 0.031 13.5 0.0 0.04 13.1 0.0 1.2 1 0 0 1 1 1 0 Fructosamine kinase WaaY PF06176.11 AIF84798.1 - 0.066 12.8 0.0 0.1 12.2 0.0 1.4 1 1 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) bPH_3 PF14470.6 AIF84799.1 - 9.8e-05 22.6 0.1 0.00016 22.0 0.1 1.3 1 1 0 1 1 1 1 Bacterial PH domain TLD PF07534.16 AIF84799.1 - 0.13 12.5 0.1 0.26 11.5 0.0 1.4 2 0 0 2 2 2 0 TLD Peptidase_M22 PF00814.25 AIF84800.1 - 6.9e-78 262.1 0.0 8.1e-78 261.8 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 AIF84800.1 - 0.12 12.0 0.1 0.47 10.1 0.0 2.0 2 1 0 2 2 2 0 Carbamoyltransferase N-terminus MMR_HSR1_C PF08438.10 AIF84801.1 - 4.5e-31 107.7 0.1 8.1e-31 106.9 0.1 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 AIF84801.1 - 3.9e-21 75.3 0.0 2.5e-20 72.7 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 AIF84801.1 - 2.1e-13 50.1 0.2 6.1e-13 48.6 0.1 1.9 2 0 0 2 2 2 1 TGS domain FeoB_N PF02421.18 AIF84801.1 - 4.3e-07 29.6 0.1 3.1e-06 26.8 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B YchF-GTPase_C PF06071.13 AIF84801.1 - 0.0087 16.2 0.1 0.042 14.0 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF933) AAA_29 PF13555.6 AIF84801.1 - 0.026 14.3 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain VF530 PF09905.9 AIF84801.1 - 0.077 13.2 0.0 0.24 11.6 0.0 1.7 2 0 0 2 2 2 0 DNA-binding protein VF530 SicP-binding PF09119.10 AIF84801.1 - 0.12 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 SicP binding ThiS PF02597.20 AIF84801.1 - 0.13 12.9 0.0 0.65 10.7 0.0 2.2 2 0 0 2 2 2 0 ThiS family Cupin_5 PF06172.11 AIF84802.1 - 2.4e-46 157.4 0.0 2.7e-46 157.2 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily (DUF985) QueC PF06508.13 AIF84803.1 - 8e-50 169.3 0.1 9.2e-50 169.1 0.1 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 AIF84803.1 - 0.00017 21.3 0.0 0.00027 20.7 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 AIF84803.1 - 0.067 12.8 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Fer4_14 PF13394.6 AIF84804.1 - 8.4e-14 51.7 0.1 1.3e-13 51.1 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 AIF84804.1 - 2.9e-13 50.3 0.1 4.7e-13 49.6 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Radical_SAM PF04055.21 AIF84804.1 - 5.5e-13 49.6 0.2 7.5e-13 49.2 0.2 1.2 1 0 0 1 1 1 1 Radical SAM superfamily GTP_cyclohydroI PF01227.22 AIF84805.1 - 2.9e-61 206.0 0.2 3.3e-61 205.8 0.2 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 AIF84805.1 - 0.0098 16.0 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 1 QueF-like protein PepSY PF03413.19 AIF84806.1 - 1.4e-05 25.6 0.3 0.00079 19.9 0.1 2.2 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain DUF998 PF06197.13 AIF84806.1 - 0.074 12.6 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF998) AAA PF00004.29 AIF84808.1 - 7.4e-16 58.8 0.2 4.8e-15 56.2 0.0 2.3 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 AIF84808.1 - 1.4e-06 28.4 0.0 2.9e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AIF84808.1 - 6.5e-06 26.2 0.0 1.6e-05 24.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AIF84808.1 - 7.6e-06 26.4 0.2 0.00012 22.5 0.0 2.6 2 1 1 3 3 3 1 AAA ATPase domain AAA_7 PF12775.7 AIF84808.1 - 5.9e-05 22.7 0.0 0.00012 21.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 AIF84808.1 - 7.9e-05 22.9 0.0 0.00054 20.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 AIF84808.1 - 8.2e-05 22.6 0.0 0.00017 21.6 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_25 PF13481.6 AIF84808.1 - 0.00023 20.8 0.0 0.00047 19.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 AIF84808.1 - 0.00041 20.1 0.0 0.0011 18.8 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 AIF84808.1 - 0.00077 20.0 0.0 0.0014 19.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_8 PF12780.7 AIF84808.1 - 0.00084 18.7 0.0 0.0016 17.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_33 PF13671.6 AIF84808.1 - 0.0012 19.1 0.0 0.0028 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AIF84808.1 - 0.0012 19.3 0.0 0.0023 18.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter NACHT PF05729.12 AIF84808.1 - 0.003 17.5 0.0 0.28 11.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.17 AIF84808.1 - 0.0038 17.0 0.0 0.008 15.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_17 PF13207.6 AIF84808.1 - 0.0057 17.1 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 AIF84808.1 - 0.0063 16.4 0.0 0.034 14.1 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Mg_chelatase PF01078.21 AIF84808.1 - 0.0095 15.3 0.0 0.019 14.4 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 AIF84808.1 - 0.012 14.8 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 AIF84808.1 - 0.012 16.0 0.0 0.027 14.9 0.0 1.7 1 1 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 AIF84808.1 - 0.013 15.7 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 AIF84808.1 - 0.014 14.7 0.0 0.031 13.5 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain NTPase_1 PF03266.15 AIF84808.1 - 0.017 15.1 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.6 AIF84808.1 - 0.036 13.8 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 AIF84808.1 - 0.037 13.9 0.0 0.12 12.3 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 AIF84808.1 - 0.042 14.2 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 AIF84808.1 - 0.046 13.8 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_29 PF13555.6 AIF84808.1 - 0.055 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 AIF84808.1 - 0.061 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 AIF84808.1 - 0.1 12.7 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 AIF84808.1 - 0.13 11.6 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Roc PF08477.13 AIF84808.1 - 0.13 12.5 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 AIF84808.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Sigma54_activ_2 PF14532.6 AIF84808.1 - 0.15 12.1 0.0 0.5 10.5 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 AIF84808.1 - 0.17 11.7 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2911 PF11138.8 AIF84809.1 - 0.04 13.8 0.0 0.051 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2911) ProRS-C_1 PF09180.11 AIF84809.1 - 0.047 13.9 3.0 4 7.7 0.8 2.5 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal zf-HC5HC2H_2 PF13832.6 AIF84809.1 - 4.7 7.4 14.2 18 5.6 14.1 1.9 1 1 0 1 1 1 0 PHD-zinc-finger like domain Vps5 PF09325.10 AIF84810.1 - 0.066 12.7 0.1 0.074 12.6 0.1 1.0 1 0 0 1 1 1 0 Vps5 C terminal like GYD PF08734.11 AIF84811.1 - 0.1 12.6 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 GYD domain ADH_zinc_N PF00107.26 AIF84812.1 - 6.2e-30 103.8 0.2 1.1e-29 103.1 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AIF84812.1 - 4.7e-25 87.6 0.1 8.9e-25 86.7 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 AIF84812.1 - 3.2e-18 67.0 0.0 5.5e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_16 PF10294.9 AIF84812.1 - 0.00081 19.2 0.1 0.0014 18.4 0.1 1.3 1 0 0 1 1 1 1 Lysine methyltransferase ACP_syn_III_C PF08541.10 AIF84812.1 - 0.0089 16.2 0.1 0.03 14.5 0.1 1.9 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal adh_short PF00106.25 AIF84812.1 - 0.032 13.7 0.1 0.047 13.1 0.1 1.2 1 0 0 1 1 1 0 short chain dehydrogenase Carboxyl_trans PF01039.22 AIF84813.1 - 7.4e-187 621.9 0.4 8.4e-187 621.7 0.4 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 AIF84813.1 - 5.8e-06 26.0 0.0 1.7e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 Malonate decarboxylase gamma subunit (MdcE) CPSase_L_D2 PF02786.17 AIF84814.1 - 2.2e-74 249.5 0.0 3.4e-74 248.9 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 AIF84814.1 - 1.2e-47 161.0 0.2 9e-47 158.2 0.1 2.2 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 AIF84814.1 - 1.3e-36 124.9 0.0 2.7e-36 123.9 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain RimK PF08443.11 AIF84814.1 - 3.4e-08 33.3 0.0 5.8e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 RimK-like ATP-grasp domain Dala_Dala_lig_C PF07478.13 AIF84814.1 - 7.4e-08 32.2 0.0 2.8e-07 30.3 0.0 1.9 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 AIF84814.1 - 5.1e-07 29.4 0.0 1e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 AIF84814.1 - 4.5e-05 23.6 0.0 0.00034 20.7 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 AIF84814.1 - 0.0076 15.5 0.1 0.15 11.3 0.0 2.6 3 0 0 3 3 3 1 Sugar-transfer associated ATP-grasp Biotin_lipoyl PF00364.22 AIF84815.1 - 2.9e-16 59.1 4.6 3.9e-16 58.6 3.1 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 AIF84815.1 - 1.2e-12 47.4 3.6 9.7e-09 34.9 0.3 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_D23 PF16576.5 AIF84815.1 - 0.00066 19.0 0.3 0.2 10.9 0.1 2.2 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 AIF84815.1 - 0.0078 16.1 0.8 0.017 15.0 0.4 1.8 2 0 0 2 2 2 1 Glycine cleavage H-protein HlyD_3 PF13437.6 AIF84815.1 - 0.042 14.6 1.5 6.7 7.5 0.0 2.8 2 2 1 3 3 3 0 HlyD family secretion protein DUF2118 PF09891.9 AIF84815.1 - 0.054 13.5 0.6 0.21 11.5 0.2 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) Activator-TraM PF11657.8 AIF84815.1 - 0.06 13.2 0.5 3.4 7.5 0.1 2.2 1 1 1 2 2 2 0 Transcriptional activator TraM SH3_2 PF07653.17 AIF84815.1 - 0.073 12.8 0.0 0.71 9.6 0.0 2.4 2 0 0 2 2 2 0 Variant SH3 domain Lactamase_B_2 PF12706.7 AIF84817.1 - 2.2e-10 40.4 0.8 3.2e-10 39.9 0.8 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AIF84817.1 - 7.8e-07 29.1 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain AhpC-TSA PF00578.21 AIF84818.1 - 1.7e-37 128.1 0.0 2.1e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIF84818.1 - 6.9e-26 90.7 0.0 8.2e-26 90.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin SCO1-SenC PF02630.14 AIF84818.1 - 0.0002 21.3 0.0 0.00037 20.4 0.0 1.5 1 1 0 1 1 1 1 SCO1/SenC AhpC-TSA_2 PF13911.6 AIF84818.1 - 0.029 14.5 0.0 1.6 8.9 0.0 2.2 1 1 1 2 2 2 0 AhpC/TSA antioxidant enzyme sCache_like PF16736.5 AIF84818.1 - 0.087 12.9 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Single Cache-like Aminotran_5 PF00266.19 AIF84819.1 - 9.8e-91 304.5 0.0 1.2e-90 304.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AIF84819.1 - 3.5e-05 23.2 0.0 5e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 AIF84819.1 - 0.00011 21.6 0.2 0.00029 20.3 0.2 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 AIF84819.1 - 0.017 13.7 0.0 0.024 13.2 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme QueC PF06508.13 AIF84820.1 - 4.4e-10 39.4 0.1 5.8e-09 35.8 0.0 2.3 2 1 0 2 2 2 1 Queuosine biosynthesis protein QueC NAD_synthase PF02540.17 AIF84820.1 - 2.7e-09 36.5 0.0 5.3e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 AIF84820.1 - 2.8e-09 37.1 0.0 3.5e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.16 AIF84820.1 - 1.7e-08 33.6 0.0 9.3e-07 28.0 0.1 2.2 2 0 0 2 2 2 1 tRNA methyl transferase ATP_bind_3 PF01171.20 AIF84820.1 - 0.00012 21.9 0.0 0.00052 19.8 0.1 2.0 1 1 0 2 2 2 1 PP-loop family Arginosuc_synth PF00764.19 AIF84820.1 - 0.0028 17.0 0.1 0.0042 16.4 0.1 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase ThiI PF02568.14 AIF84820.1 - 0.0041 16.7 0.0 0.0075 15.9 0.0 1.4 1 1 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) PAPS_reduct PF01507.19 AIF84820.1 - 0.05 13.6 0.0 0.077 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family HTH_CodY PF08222.11 AIF84820.1 - 0.06 12.9 0.4 6.3 6.4 0.1 2.4 2 0 0 2 2 2 0 CodY helix-turn-helix domain DUF4432 PF14486.6 AIF84820.1 - 0.073 11.8 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4432) DUF111 PF01969.17 AIF84821.1 - 2.2e-105 352.8 2.7 2.5e-105 352.7 2.7 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF111 HypA PF01155.19 AIF84822.1 - 0.074 13.1 0.1 0.096 12.7 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CbtA PF09490.10 AIF84825.1 - 9.5e-13 48.5 28.0 2.7e-12 47.0 28.0 1.6 1 1 0 1 1 1 1 Probable cobalt transporter subunit (CbtA) COX6C PF02937.15 AIF84825.1 - 0.031 14.4 0.1 0.031 14.4 0.1 3.0 3 1 0 3 3 3 0 Cytochrome c oxidase subunit VIc Yip1 PF04893.17 AIF84825.1 - 0.037 13.7 17.5 0.068 12.9 3.7 2.4 2 1 0 2 2 2 0 Yip1 domain ABC2_membrane_4 PF12730.7 AIF84825.1 - 0.046 13.7 1.2 0.1 12.6 0.0 2.0 2 1 0 2 2 2 0 ABC-2 family transporter protein Tail_VII PF17091.5 AIF84825.1 - 0.06 13.2 1.7 0.06 13.2 1.7 2.6 2 0 0 2 2 2 0 Inovirus G7P protein MFS_1 PF07690.16 AIF84826.1 - 6.7e-36 123.9 42.4 7.6e-28 97.4 28.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 AIF84826.1 - 6.1e-06 25.3 17.1 0.00037 19.5 17.0 2.1 1 1 0 1 1 1 1 MFS_1 like family Sugar_tr PF00083.24 AIF84826.1 - 0.00036 19.5 7.6 0.00036 19.5 7.6 2.6 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.6 AIF84826.1 - 0.0054 15.3 31.6 0.041 12.4 15.5 2.4 1 1 0 2 2 2 2 MFS/sugar transport protein HTH_CodY PF08222.11 AIF84826.1 - 0.11 12.1 0.0 5.7 6.6 0.0 2.4 2 0 0 2 2 2 0 CodY helix-turn-helix domain Chrome_Resist PF09828.9 AIF84827.1 - 1.7e-47 161.2 0.1 1.9e-47 161.0 0.1 1.0 1 0 0 1 1 1 1 Chromate resistance exported protein DUF2154 PF09922.9 AIF84828.1 - 0.00028 20.7 0.3 0.00074 19.4 0.3 1.7 1 0 0 1 1 1 1 Cell wall-active antibiotics response 4TMS YvqF Toxin_9 PF02819.15 AIF84829.1 - 0.0033 17.7 4.1 0.0058 16.9 4.1 1.4 1 0 0 1 1 1 1 Spider toxin TruB_N PF01509.18 AIF84830.1 - 1.2e-23 84.2 0.9 1.8e-15 57.6 0.0 3.2 1 1 1 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 AIF84830.1 - 2e-19 69.5 0.1 4.6e-19 68.3 0.1 1.7 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain DKCLD PF08068.12 AIF84830.1 - 3.1e-14 52.8 0.1 5.5e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 DKCLD (NUC011) domain PUA PF01472.20 AIF84830.1 - 3.2e-14 52.6 0.6 6.1e-14 51.7 0.6 1.4 1 0 0 1 1 1 1 PUA domain SmaI PF17411.2 AIF84830.1 - 0.013 14.6 0.1 0.02 14.1 0.1 1.1 1 0 0 1 1 1 0 Type II site-specific deoxyribonuclease Cytidylate_kin2 PF13189.6 AIF84831.1 - 5.1e-15 56.1 0.0 7.2e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Cytidylate kinase-like family AAA_18 PF13238.6 AIF84831.1 - 8.6e-11 42.5 0.0 1.2e-10 42.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 AIF84831.1 - 5.6e-07 30.1 0.1 1.3e-06 28.9 0.1 1.6 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 AIF84831.1 - 5.6e-05 23.0 0.2 0.14 11.9 0.0 2.1 1 1 1 2 2 2 2 Cytidylate kinase AAA PF00004.29 AIF84831.1 - 0.0063 16.9 0.2 0.012 16.1 0.1 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 AIF84831.1 - 0.01 16.0 0.0 0.017 15.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 AIF84831.1 - 0.011 15.2 0.0 0.017 14.6 0.0 1.4 1 1 0 1 1 1 0 Chromatin associated protein KTI12 RNA_helicase PF00910.22 AIF84831.1 - 0.016 15.6 0.0 0.023 15.1 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 AIF84831.1 - 0.022 15.0 0.0 0.043 14.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AIF84831.1 - 0.024 15.0 0.0 0.027 14.9 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ADK PF00406.22 AIF84831.1 - 0.044 13.9 0.1 0.12 12.4 0.0 1.7 2 0 0 2 2 2 0 Adenylate kinase dNK PF01712.19 AIF84831.1 - 0.08 12.8 0.1 0.19 11.6 0.0 1.8 2 1 0 2 2 2 0 Deoxynucleoside kinase Hydin_ADK PF17213.3 AIF84831.1 - 0.09 13.1 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain RuvB_N PF05496.12 AIF84831.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain EMC3_TMCO1 PF01956.16 AIF84832.1 - 3.2e-11 43.3 8.7 2.4e-10 40.4 8.7 1.9 1 1 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like KCH PF16944.5 AIF84832.1 - 0.024 14.4 0.1 0.038 13.8 0.1 1.3 1 0 0 1 1 1 0 Fungal potassium channel SUIM_assoc PF16619.5 AIF84832.1 - 0.92 9.6 3.9 0.52 10.4 0.6 1.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 AAA_17 PF13207.6 AIF84833.1 - 8.5e-32 110.4 0.1 1e-31 110.2 0.1 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AIF84833.1 - 5.3e-08 33.5 0.0 8.6e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 AIF84833.1 - 1.6e-05 24.6 0.3 3.3e-05 23.6 0.3 1.5 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 AIF84833.1 - 0.00011 22.3 0.0 0.00017 21.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 AIF84833.1 - 0.00014 22.1 0.2 0.00021 21.6 0.2 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AIF84833.1 - 0.00094 19.5 0.3 0.0022 18.3 0.3 1.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AIF84833.1 - 0.0012 18.6 0.4 0.0023 17.7 0.4 1.4 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 AIF84833.1 - 0.0015 18.1 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 ResIII PF04851.15 AIF84833.1 - 0.0024 17.9 0.5 0.0083 16.1 0.5 1.7 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 AIF84833.1 - 0.0035 17.3 1.1 0.0082 16.1 1.1 1.7 1 1 0 1 1 1 1 NTPase AAA_19 PF13245.6 AIF84833.1 - 0.0049 17.2 1.4 0.012 15.9 1.4 1.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AIF84833.1 - 0.0064 16.5 0.2 0.032 14.2 0.0 1.9 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 AIF84833.1 - 0.01 15.6 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA PF00004.29 AIF84833.1 - 0.015 15.7 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AIF84833.1 - 0.029 14.8 0.1 0.059 13.7 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 AIF84833.1 - 0.048 13.2 0.1 0.12 11.9 0.1 1.9 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 AIF84833.1 - 0.049 13.4 0.2 0.11 12.2 0.2 1.7 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 AIF84833.1 - 0.054 12.9 0.1 0.14 11.5 0.1 1.7 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI ATP_bind_1 PF03029.17 AIF84833.1 - 0.054 13.3 0.4 0.51 10.1 0.1 2.4 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF2075 PF09848.9 AIF84833.1 - 0.069 12.4 0.0 0.076 12.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MMR_HSR1 PF01926.23 AIF84833.1 - 0.091 12.8 0.3 0.17 12.0 0.3 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.6 AIF84833.1 - 0.43 10.1 1.9 2.9 7.4 0.1 2.3 1 1 0 2 2 2 0 AAA domain SecY PF00344.20 AIF84834.1 - 3.7e-64 216.9 16.9 4.6e-64 216.6 16.9 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 AIF84834.1 - 9.9e-13 47.7 0.6 9.9e-13 47.7 0.6 2.3 2 0 0 2 2 2 1 Plug domain of Sec61p Ribosomal_L27A PF00828.19 AIF84835.1 - 1.1e-15 58.5 1.0 1.6e-15 57.9 1.0 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_L18 PF17135.4 AIF84835.1 - 0.025 14.0 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L30 PF00327.20 AIF84836.1 - 1e-11 44.5 0.0 2e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_S5 PF00333.20 AIF84837.1 - 6.4e-22 77.3 2.1 1.7e-21 76.0 1.5 1.9 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 AIF84837.1 - 1.2e-17 63.2 0.1 1.7e-17 62.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_L5e PF17144.4 AIF84838.1 - 9.6e-15 55.0 0.9 1.1e-12 48.2 0.2 3.1 2 1 1 3 3 3 2 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 AIF84838.1 - 7.6e-08 33.2 17.2 1.6e-07 32.2 14.6 2.5 2 1 0 2 2 2 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 AIF84838.1 - 0.002 18.5 0.1 0.0048 17.3 0.1 1.6 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast FliD_C PF07195.12 AIF84838.1 - 0.0075 15.7 0.0 0.015 14.7 0.0 1.5 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 C-terminus AIRC PF00731.20 AIF84839.1 - 1.1e-15 57.5 8.8 1.1e-15 57.5 8.8 1.6 2 0 0 2 2 2 1 AIR carboxylase YscJ_FliF PF01514.17 AIF84839.1 - 0.0006 19.5 0.3 0.0011 18.6 0.3 1.4 1 0 0 1 1 1 1 Secretory protein of YscJ/FliF family adh_short PF00106.25 AIF84839.1 - 0.0099 15.4 4.9 0.017 14.6 4.9 1.4 1 0 0 1 1 1 1 short chain dehydrogenase VbhA PF18495.1 AIF84839.1 - 0.062 13.2 0.1 0.19 11.6 0.1 1.8 1 0 0 1 1 1 0 Antitoxin VbhA AF0941-like PF14591.6 AIF84839.1 - 0.14 12.7 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 AF0941-like Ldh_1_N PF00056.23 AIF84840.1 - 2.3e-36 125.0 0.9 2.3e-36 125.0 0.9 1.9 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 AIF84840.1 - 5.8e-24 84.9 0.1 8.6e-24 84.3 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 AIF84840.1 - 0.016 14.8 0.4 0.093 12.3 0.1 2.1 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase UDPG_MGDP_dh_N PF03721.14 AIF84840.1 - 0.024 14.2 1.7 0.035 13.7 0.6 1.8 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF1648 PF07853.11 AIF84841.1 - 0.12 12.1 0.4 0.77 9.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1648) DUF4307 PF14155.6 AIF84841.1 - 0.19 11.5 0.1 0.34 10.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) YcaO PF02624.16 AIF84842.1 - 2.1e-74 250.7 0.1 1.9e-36 126.0 0.0 2.0 1 1 1 2 2 2 2 YcaO cyclodehydratase, ATP-ad Mg2+-binding TfuA PF07812.12 AIF84843.1 - 1.1e-34 118.7 0.0 1.6e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 TfuA-like protein Cob_adeno_trans PF01923.18 AIF84844.1 - 6.9e-53 179.1 0.0 7.8e-53 179.0 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase zf-C2H2 PF00096.26 AIF84846.1 - 6.4e-06 26.3 0.6 7.6e-06 26.1 0.6 1.1 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-Di19 PF05605.12 AIF84846.1 - 2.9e-05 24.3 0.1 3.4e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 AIF84846.1 - 4.6e-05 23.9 0.2 5.9e-05 23.6 0.2 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AIF84846.1 - 0.0008 19.7 1.8 0.2 12.1 0.1 2.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_2 PF12756.7 AIF84846.1 - 0.00092 19.5 0.1 0.00092 19.5 0.1 1.0 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-ribbon_3 PF13248.6 AIF84846.1 - 0.0065 15.8 0.1 0.0096 15.3 0.1 1.3 1 0 0 1 1 1 1 zinc-ribbon domain zf-CHCC PF10276.9 AIF84846.1 - 0.0089 16.1 0.1 0.012 15.7 0.1 1.2 1 0 0 1 1 1 1 Zinc-finger domain HNH PF01844.23 AIF84846.1 - 0.015 15.5 0.2 0.016 15.4 0.2 1.2 1 0 0 1 1 1 0 HNH endonuclease zf-C2H2_9 PF16293.5 AIF84846.1 - 0.015 15.1 0.0 0.017 15.0 0.0 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_9 PF14369.6 AIF84846.1 - 0.017 15.4 0.2 0.026 14.8 0.2 1.3 1 0 0 1 1 1 0 zinc-ribbon TRAF6_Z2 PF18048.1 AIF84846.1 - 0.019 15.1 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 DUF4187 PF13821.6 AIF84846.1 - 0.025 14.4 0.1 0.03 14.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) DUF2225 PF09986.9 AIF84846.1 - 0.032 13.9 0.0 0.032 13.9 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zinc_ribbon_2 PF13240.6 AIF84846.1 - 0.033 13.9 0.1 0.045 13.5 0.1 1.3 1 0 0 1 1 1 0 zinc-ribbon domain zf-C2H2_3rep PF18868.1 AIF84846.1 - 0.038 14.7 0.0 0.038 14.7 0.0 1.0 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 AIF84846.1 - 0.055 13.8 0.1 0.065 13.5 0.1 1.2 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 AIF84846.1 - 0.061 13.0 0.0 0.061 13.0 0.0 1.1 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain Rad50_zn_hook PF04423.14 AIF84846.1 - 0.062 13.1 0.1 0.076 12.9 0.1 1.2 1 0 0 1 1 1 0 Rad50 zinc hook motif zinc_ribbon_5 PF13719.6 AIF84846.1 - 0.063 13.0 0.1 0.079 12.7 0.1 1.2 1 0 0 1 1 1 0 zinc-ribbon domain FOXP-CC PF16159.5 AIF84846.1 - 0.11 13.1 0.1 0.12 13.0 0.1 1.1 1 0 0 1 1 1 0 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 AIF84846.1 - 0.15 11.8 4.8 0.82 9.5 4.8 2.0 1 1 0 1 1 1 0 C2H2-type zinc-finger domain HD_3 PF13023.6 AIF84847.1 - 2.2e-35 122.0 0.1 2.6e-35 121.8 0.1 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 AIF84847.1 - 3.1e-14 53.1 0.0 4.8e-14 52.5 0.0 1.3 1 1 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 AIF84847.1 - 9.9e-05 22.6 0.3 0.00029 21.1 0.3 1.8 1 1 0 1 1 1 1 HD domain CTI PF06934.11 AIF84847.1 - 0.088 11.3 0.1 0.1 11.1 0.1 1.0 1 0 0 1 1 1 0 Fatty acid cis/trans isomerase (CTI) DUF1958 PF09211.10 AIF84848.1 - 0.029 14.7 0.0 2.8 8.3 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1958) Saccharop_dh_N PF04455.12 AIF84849.1 - 2.9e-36 123.9 0.0 7.9e-36 122.5 0.0 1.8 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region DS PF01916.17 AIF84849.1 - 0.016 14.5 0.1 0.092 12.0 0.1 2.1 1 1 1 2 2 2 0 Deoxyhypusine synthase Band_7 PF01145.25 AIF84850.1 - 1.9e-33 116.0 8.0 3.2e-33 115.2 8.0 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 AIF84850.1 - 0.0002 21.2 0.5 0.00041 20.1 0.5 1.5 1 0 0 1 1 1 1 SPFH domain-Band 7 family Tyr_Deacylase PF02580.16 AIF84850.1 - 0.0099 16.4 0.3 0.034 14.7 0.1 2.0 1 1 1 2 2 2 1 D-Tyr-tRNA(Tyr) deacylase TMEM100 PF16311.5 AIF84850.1 - 1.3 8.6 3.9 3.4 7.2 3.9 1.7 1 0 0 1 1 1 0 Transmembrane protein 100 DUF3040 PF11239.8 AIF84850.1 - 2.3 8.5 6.6 4.6 7.6 6.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) SelR PF01641.18 AIF84851.1 - 7.6e-54 181.0 0.5 8.5e-54 180.8 0.5 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 AIF84851.1 - 0.00045 20.4 0.0 0.00071 19.7 0.0 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly GFA PF04828.14 AIF84851.1 - 0.0017 18.7 0.4 1.2 9.6 0.1 2.1 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme HECT_2 PF09814.9 AIF84851.1 - 0.0041 16.0 0.6 0.67 8.8 0.0 2.0 1 1 1 2 2 2 2 HECT-like Ubiquitin-conjugating enzyme (E2)-binding zinc_ribbon_2 PF13240.6 AIF84851.1 - 0.0047 16.6 1.1 2.8 7.8 0.1 2.7 2 0 0 2 2 2 2 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 AIF84851.1 - 0.0052 16.3 0.2 2.7 7.6 0.0 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding zf-ribbon_3 PF13248.6 AIF84851.1 - 0.011 15.1 0.5 3.2 7.3 0.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_10 PF10058.9 AIF84851.1 - 0.02 14.6 0.9 2.4 7.9 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 AIF84851.1 - 0.043 13.8 2.5 0.27 11.3 1.7 2.4 1 1 1 2 2 2 0 Double zinc ribbon Tnp_zf-ribbon_2 PF13842.6 AIF84851.1 - 0.045 14.6 0.1 5 8.0 0.0 2.4 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Lar_restr_allev PF14354.6 AIF84851.1 - 0.067 13.6 2.7 2.4 8.6 0.1 2.3 1 1 1 2 2 2 0 Restriction alleviation protein Lar Ribosomal_S27e PF01667.17 AIF84851.1 - 0.07 12.8 0.1 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Ribosomal protein S27 DUF678 PF05077.12 AIF84851.1 - 0.077 13.1 0.1 5.5 7.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF678) zf-tcix PF14952.6 AIF84851.1 - 0.1 12.3 0.8 11 5.7 0.1 2.6 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding Zn-ribbon_8 PF09723.10 AIF84851.1 - 0.1 12.7 0.5 5.8 7.1 0.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain DUF983 PF06170.12 AIF84851.1 - 0.12 12.8 1.0 14 6.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Zn_Tnp_IS1595 PF12760.7 AIF84851.1 - 0.21 11.6 2.7 3.5 7.7 1.3 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 AIF84853.1 - 0.028 14.4 0.2 0.038 13.9 0.2 1.3 1 0 0 1 1 1 0 zinc-ribbon domain RNA_pol_N PF01194.17 AIF84853.1 - 0.048 14.0 0.6 0.053 13.8 0.6 1.3 1 1 0 1 1 1 0 RNA polymerases N / 8 kDa subunit zf-C2HC_2 PF13913.6 AIF84853.1 - 0.21 11.6 0.1 0.21 11.6 0.1 1.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type YHS PF04945.13 AIF84854.1 - 6.9e-14 51.7 2.6 7.2e-14 51.6 2.6 1.0 1 0 0 1 1 1 1 YHS domain ATPase-cat_bd PF12156.8 AIF84854.1 - 0.00074 20.2 1.3 0.00088 20.0 1.3 1.1 1 0 0 1 1 1 1 Putative metal-binding domain of cation transport ATPase Arc_trans_TRASH PF08394.10 AIF84854.1 - 0.0011 19.2 2.2 0.0019 18.5 2.2 1.3 1 1 0 1 1 1 1 Archaeal TRASH domain zinc_ribbon_4 PF13717.6 AIF84854.1 - 0.0046 16.8 1.4 0.0076 16.1 1.4 1.4 1 0 0 1 1 1 1 zinc-ribbon domain PadR PF03551.14 AIF84855.1 - 4.5e-13 49.0 0.0 1e-12 47.8 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family RTP PF02334.16 AIF84855.1 - 3.3e-06 27.7 0.0 8.5e-06 26.4 0.0 1.6 2 0 0 2 2 2 1 Replication terminator protein TrmB PF01978.19 AIF84855.1 - 0.011 15.6 0.1 0.11 12.4 0.0 2.5 2 1 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 AIF84855.1 - 0.016 15.0 0.0 0.23 11.3 0.0 2.3 2 0 0 2 2 2 0 IclR helix-turn-helix domain SMC_Nse1 PF07574.13 AIF84855.1 - 0.018 14.9 0.1 0.031 14.2 0.0 1.5 2 0 0 2 2 2 0 Nse1 non-SMC component of SMC5-6 complex DUF4423 PF14394.6 AIF84855.1 - 0.031 14.0 0.1 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) zf-ZPR1 PF03367.13 AIF84855.1 - 0.035 14.0 0.0 0.045 13.6 0.0 1.2 1 0 0 1 1 1 0 ZPR1 zinc-finger domain HTH_45 PF14947.6 AIF84855.1 - 0.047 13.7 0.1 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix Zn_clus PF00172.18 AIF84856.1 - 0.021 14.9 1.3 0.19 11.9 0.2 2.0 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain GatB_N PF02934.15 AIF84857.1 - 2.2e-95 319.2 0.0 2.9e-95 318.8 0.0 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 AIF84857.1 - 7.2e-34 116.8 3.0 1.3e-33 116.0 3.0 1.4 1 0 0 1 1 1 1 GatB domain Amidase PF01425.21 AIF84858.1 - 3.2e-154 514.2 0.2 3.7e-154 514.0 0.2 1.0 1 0 0 1 1 1 1 Amidase Glu-tRNAGln PF02686.15 AIF84859.1 - 9e-06 25.9 0.1 1.3e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit tRNA-synt_2 PF00152.20 AIF84860.1 - 4.6e-83 278.9 0.0 5.6e-83 278.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AIF84860.1 - 1.3e-13 50.7 0.1 2.4e-13 49.9 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AIF84860.1 - 0.0028 17.2 0.4 0.0085 15.6 0.0 1.9 3 0 0 3 3 3 1 tRNA synthetases class II core domain (F) sCache_3_2 PF17203.4 AIF84860.1 - 0.022 14.9 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 Single cache domain 3 DHHA1 PF02272.19 AIF84863.1 - 0.00015 22.2 3.9 0.00066 20.1 3.8 2.2 1 1 1 2 2 2 1 DHHA1 domain tRNA_SAD PF07973.14 AIF84863.1 - 0.0026 17.8 0.1 0.006 16.6 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain RepA_N PF06970.11 AIF84863.1 - 0.1 12.6 0.1 0.22 11.5 0.1 1.5 1 0 0 1 1 1 0 Replication initiator protein A (RepA) N-terminus Cas_Cas1 PF01867.16 AIF84864.1 - 2.4e-16 59.7 0.1 3.2e-16 59.3 0.1 1.1 1 0 0 1 1 1 1 CRISPR associated protein Cas1 CheR PF01739.18 AIF84864.1 - 0.019 14.5 0.2 0.024 14.1 0.2 1.1 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain P2_N PF18628.1 AIF84864.1 - 0.08 12.7 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 Viral coat protein P2 N-terminal domain PD40 PF07676.12 AIF84865.1 - 8e-41 137.2 12.2 4.3e-10 39.3 0.2 6.3 6 0 0 6 6 6 5 WD40-like Beta Propeller Repeat DUF5050 PF16472.5 AIF84865.1 - 1.7e-12 47.2 2.0 8.6e-05 21.9 0.0 4.0 4 0 0 4 4 4 4 Domain of unknown function (DUF5050) DPPIV_N PF00930.21 AIF84865.1 - 2.3e-10 39.8 10.1 0.00047 19.0 2.9 4.3 1 1 3 4 4 4 3 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pectate_lyase22 PF14583.6 AIF84865.1 - 0.00033 19.5 0.7 0.12 11.0 0.0 2.8 1 1 0 2 2 2 2 Oligogalacturonate lyase Gmad1 PF10647.9 AIF84865.1 - 0.00081 19.2 0.1 1.8 8.3 0.0 2.8 2 2 0 2 2 2 2 Lipoprotein LpqB beta-propeller domain Inh PF02974.14 AIF84865.1 - 0.0038 17.3 0.4 24 5.1 0.0 3.9 2 2 1 3 3 3 0 Protease inhibitor Inh ChitinaseA_N PF08329.10 AIF84865.1 - 0.01 15.5 3.1 9.9 5.8 0.1 4.1 5 0 0 5 5 5 0 Chitinase A, N-terminal domain tRNA_anti-codon PF01336.25 AIF84865.1 - 0.092 12.7 1.0 3.4 7.7 0.0 3.6 4 1 0 4 4 4 0 OB-fold nucleic acid binding domain M-factor PF03855.13 AIF84865.1 - 9.3 6.5 6.8 22 5.3 0.1 3.6 4 0 0 4 4 4 0 M-factor DUF4469 PF14734.6 AIF84866.1 - 0.011 15.9 0.1 0.1 12.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4469) with IG-like fold Cadherin_5 PF17892.1 AIF84866.1 - 0.039 13.9 0.3 3.6 7.6 0.0 2.9 3 0 0 3 3 3 0 Cadherin-like domain Glyco_hydro_61 PF03443.14 AIF84866.1 - 0.091 12.7 0.0 0.19 11.6 0.0 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 61 Hydrolase_4 PF12146.8 AIF84870.1 - 3.4e-11 42.9 0.0 7.5e-08 31.9 0.0 2.5 3 0 0 3 3 3 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 AIF84870.1 - 9.1e-11 41.6 0.0 0.00047 19.7 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 AIF84870.1 - 7.3e-09 35.5 0.0 0.00023 20.8 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 AIF84870.1 - 1.9e-07 31.9 0.0 7.7e-07 29.9 0.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family BAAT_C PF08840.11 AIF84870.1 - 6.8e-06 26.1 0.0 0.0013 18.7 0.0 2.2 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal AXE1 PF05448.12 AIF84870.1 - 2.3e-05 23.2 0.0 0.00034 19.4 0.0 2.1 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.16 AIF84870.1 - 0.0018 18.1 0.0 0.7 9.7 0.0 2.8 2 1 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 AIF84870.1 - 0.006 16.3 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 AIF84870.1 - 0.12 12.2 0.1 0.26 11.1 0.0 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold Acyl_transf_2 PF02273.15 AIF84870.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Acyl transferase Putative_PNPOx PF01243.20 AIF84871.1 - 9.9e-06 25.7 0.0 1.6e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIF84871.1 - 0.0011 18.6 0.0 0.0014 18.2 0.0 1.5 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Pyridox_ox_2 PF12900.7 AIF84871.1 - 0.0066 16.5 0.0 0.0073 16.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase adh_short PF00106.25 AIF84873.1 - 4e-42 143.9 0.0 5.9e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIF84873.1 - 3.8e-33 115.0 0.0 5.4e-33 114.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIF84873.1 - 1e-12 48.3 0.1 1.5e-12 47.8 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AIF84873.1 - 8.2e-05 22.2 0.0 0.00016 21.2 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF3439 PF11921.8 AIF84873.1 - 1.6 8.7 4.9 5 7.1 3.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3439) Rieske PF00355.26 AIF84874.1 - 1.4e-06 28.2 0.0 2.2e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain TAT_signal PF10518.9 AIF84874.1 - 0.0061 16.4 0.1 0.011 15.6 0.1 1.4 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.9 AIF84874.1 - 0.069 12.5 1.3 0.17 11.2 1.3 1.6 1 1 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal HTH_20 PF12840.7 AIF84875.1 - 7.2e-07 29.2 3.4 1.1e-06 28.6 0.7 2.6 3 0 0 3 3 3 1 Helix-turn-helix domain MarR_2 PF12802.7 AIF84875.1 - 1.3e-05 25.0 1.0 3.5e-05 23.6 0.3 2.0 2 0 0 2 2 2 1 MarR family DUF1724 PF08350.10 AIF84875.1 - 0.00042 20.4 0.0 0.00084 19.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1724) HTH_Crp_2 PF13545.6 AIF84875.1 - 0.0076 16.2 0.7 0.074 13.0 0.1 2.4 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_5 PF01022.20 AIF84875.1 - 0.019 14.8 0.1 0.047 13.6 0.1 1.7 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family TxDE PF18711.1 AIF84875.1 - 0.02 15.0 0.1 0.056 13.6 0.0 1.8 2 0 0 2 2 2 0 Toxoflavin-degrading enzyme HTH_CodY PF08222.11 AIF84875.1 - 0.033 13.7 0.2 10 5.7 0.0 3.0 3 0 0 3 3 3 0 CodY helix-turn-helix domain HTH_IclR PF09339.10 AIF84875.1 - 0.038 13.8 0.1 0.088 12.6 0.1 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_24 PF13412.6 AIF84875.1 - 0.038 13.6 0.0 0.077 12.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 AIF84875.1 - 0.13 12.3 0.3 1.2 9.2 0.1 2.2 2 0 0 2 2 2 0 HTH domain CarboxypepD_reg PF13620.6 AIF84876.1 - 1.8e-09 37.7 0.1 4.4e-09 36.5 0.1 1.7 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Aph-1 PF06105.12 AIF84877.1 - 0.004 16.6 0.2 0.0074 15.7 0.2 1.4 1 0 0 1 1 1 1 Aph-1 protein 7TM-7TMR_HD PF07698.11 AIF84877.1 - 0.072 12.8 4.1 0.11 12.3 3.7 1.5 1 1 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF308 PF03729.13 AIF84877.1 - 7.2 7.0 16.6 0.23 11.8 5.5 2.6 2 1 1 3 3 3 0 Short repeat of unknown function (DUF308) DUF1297 PF06973.12 AIF84878.1 - 7.4e-75 250.6 0.0 9.8e-75 250.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) DUF1246 PF06849.12 AIF84878.1 - 6e-44 148.9 0.0 8.4e-44 148.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1246) CPSase_L_D2 PF02786.17 AIF84878.1 - 0.017 14.6 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Invasin_D3 PF09134.10 AIF84879.1 - 0.034 14.4 0.4 0.034 14.4 0.4 4.4 3 1 1 4 4 4 0 Invasin, domain 3 DUF2098 PF09871.9 AIF84880.1 - 0.067 13.5 0.0 0.26 11.6 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) HTH_5 PF01022.20 AIF84883.1 - 1.2e-13 50.7 0.1 9.8e-11 41.3 0.0 2.5 2 0 0 2 2 2 2 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 AIF84883.1 - 2.8e-13 49.2 0.0 1.1e-05 24.9 0.0 2.4 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 AIF84883.1 - 1.8e-09 37.3 0.3 4.2e-06 26.6 0.0 2.2 2 0 0 2 2 2 2 MarR family HTH_20 PF12840.7 AIF84883.1 - 1.1e-07 31.8 0.1 0.0025 17.8 0.0 2.4 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_34 PF13601.6 AIF84883.1 - 8.7e-06 25.8 0.0 0.033 14.3 0.0 2.3 2 0 0 2 2 2 2 Winged helix DNA-binding domain MarR PF01047.22 AIF84883.1 - 2.4e-05 24.2 0.0 0.21 11.6 0.0 2.3 2 0 0 2 2 2 2 MarR family LexA_DNA_bind PF01726.16 AIF84883.1 - 0.00012 21.8 0.3 0.24 11.2 0.0 2.8 2 2 0 2 2 2 2 LexA DNA binding domain HTH_IclR PF09339.10 AIF84883.1 - 0.00015 21.5 0.2 0.0081 15.9 0.0 2.3 2 0 0 2 2 2 1 IclR helix-turn-helix domain TrmB PF01978.19 AIF84883.1 - 0.00041 20.2 0.1 0.004 17.0 0.0 2.2 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Rrf2 PF02082.20 AIF84883.1 - 0.00052 20.3 0.1 0.032 14.6 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulator HTH_40 PF14493.6 AIF84883.1 - 0.0013 19.1 0.0 0.003 18.0 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.6 AIF84883.1 - 0.0017 18.3 0.1 0.069 13.1 0.0 2.5 2 1 0 2 2 2 1 Crp-like helix-turn-helix domain Cdc6_C PF09079.11 AIF84883.1 - 0.015 15.2 0.0 0.54 10.3 0.0 2.5 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain Penicillinase_R PF03965.16 AIF84883.1 - 0.022 15.1 0.1 0.1 13.0 0.0 2.1 2 1 0 2 2 2 0 Penicillinase repressor Sulfolobus_pRN PF05584.11 AIF84883.1 - 0.025 14.6 0.0 0.11 12.6 0.0 2.0 2 1 0 2 2 2 0 Sulfolobus plasmid regulatory protein HTH_38 PF13936.6 AIF84883.1 - 0.035 13.9 0.4 0.11 12.3 0.0 2.1 3 0 0 3 3 1 0 Helix-turn-helix domain RP-C PF03428.13 AIF84883.1 - 0.041 13.5 0.1 1 9.0 0.0 2.1 2 0 0 2 2 2 0 Replication protein C N-terminal domain baeRF_family10 PF18854.1 AIF84883.1 - 0.049 13.9 0.1 0.14 12.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 HTH_DeoR PF08220.12 AIF84883.1 - 0.064 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain DprA_WH PF17782.1 AIF84883.1 - 0.065 13.4 0.1 1.2 9.3 0.0 2.7 2 2 0 2 2 2 0 DprA winged helix domain DUF3489 PF11994.8 AIF84883.1 - 0.15 12.1 0.0 5.2 7.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3489) MASE3 PF17159.4 AIF84884.1 - 0.044 13.4 10.9 0.014 15.0 8.0 1.6 1 1 1 2 2 2 0 Membrane-associated sensor domain Arteri_Gl PF00951.18 AIF84884.1 - 1.4 8.7 6.7 1.7 8.4 6.1 1.4 1 1 0 1 1 1 0 Arterivirus GL envelope glycoprotein CopD PF05425.13 AIF84885.1 - 1.3e-18 67.3 8.0 1.3e-18 67.3 8.0 4.0 4 1 0 4 4 4 1 Copper resistance protein D CopC PF04234.12 AIF84885.1 - 7e-10 39.8 0.0 1.8e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 CopC domain UPF0093 PF03653.13 AIF84885.1 - 0.065 13.5 1.0 0.17 12.1 1.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0093) YtkA PF13115.6 AIF84885.1 - 0.31 11.7 0.0 0.31 11.7 0.0 2.8 3 0 0 3 3 3 0 YtkA-like CopC PF04234.12 AIF84887.1 - 3.1e-17 63.4 0.1 9.3e-17 61.9 0.1 1.9 1 0 0 1 1 1 1 CopC domain SGL PF08450.12 AIF84887.1 - 1.9e-14 53.9 0.3 6.9e-05 22.5 0.0 3.7 2 2 1 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region CopD PF05425.13 AIF84887.1 - 5.3e-10 39.6 6.4 5.3e-10 39.6 6.4 3.5 3 1 2 5 5 5 1 Copper resistance protein D Reg_prop PF07494.11 AIF84887.1 - 2.5e-06 27.0 9.1 7.5 7.2 0.0 7.3 8 0 0 8 8 8 2 Two component regulator propeller DUF4149 PF13664.6 AIF84887.1 - 7.7e-05 23.0 4.3 7.7e-05 23.0 4.3 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4149) YtkA PF13115.6 AIF84887.1 - 0.018 15.7 0.0 0.061 13.9 0.0 2.0 1 0 0 1 1 1 0 YtkA-like SBBP PF06739.11 AIF84887.1 - 0.12 12.3 1.0 80 3.4 0.0 4.0 4 0 0 4 4 4 0 Beta-propeller repeat YtkA PF13115.6 AIF84888.1 - 0.0011 19.5 0.3 0.0024 18.4 0.2 1.6 1 1 0 1 1 1 1 YtkA-like LPP PF04728.13 AIF84888.1 - 1.1 9.7 5.5 5.8 7.4 5.5 2.3 1 1 0 1 1 1 0 Lipoprotein leucine-zipper Filamin PF00630.19 AIF84889.1 - 0.0088 16.8 0.0 0.013 16.3 0.0 1.3 1 0 0 1 1 1 1 Filamin/ABP280 repeat Copper-bind PF00127.20 AIF84891.1 - 1.3e-08 35.2 1.7 2.6e-06 27.8 0.0 2.5 2 1 1 3 3 3 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF84891.1 - 1.8e-06 28.0 0.7 0.0012 19.0 0.0 2.7 2 2 0 2 2 2 2 Cupredoxin-like domain DUF5462 PF17547.2 AIF84891.1 - 0.026 13.9 0.1 0.19 11.1 0.0 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5462) BetaGal_dom3 PF13363.6 AIF84891.1 - 0.9 9.2 4.6 0.62 9.7 0.3 2.5 2 1 1 3 3 3 0 Beta-galactosidase, domain 3 CBM60 PF16841.5 AIF84891.1 - 1.2 9.6 8.4 0.57 10.6 0.4 2.9 3 1 0 3 3 3 0 Ca-dependent carbohydrate-binding module xylan-binding Peripla_BP_2 PF01497.18 AIF84892.1 - 4.7e-16 59.1 0.0 1.7e-15 57.3 0.0 1.8 1 1 0 1 1 1 1 Periplasmic binding protein Spexin PF15171.6 AIF84892.1 - 0.07 13.3 0.1 0.72 10.1 0.0 2.1 2 0 0 2 2 2 0 Neuropeptide secretory protein family, NPQ, spexin Ribosomal_S10 PF00338.22 AIF84893.1 - 9.4e-25 86.7 0.0 1e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e GTP_EFTU PF00009.27 AIF84894.1 - 4.3e-48 163.4 0.0 7.4e-48 162.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AIF84894.1 - 1.9e-36 124.8 0.0 4.6e-36 123.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AIF84894.1 - 1.3e-15 57.6 3.5 5.5e-15 55.5 1.7 2.6 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 AIF84894.1 - 1.4e-06 28.1 1.9 2.6e-06 27.2 1.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 AIF84894.1 - 0.0027 17.8 0.2 0.017 15.2 0.2 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase NTPase_1 PF03266.15 AIF84894.1 - 0.06 13.3 0.1 2.4 8.1 0.0 2.4 2 0 0 2 2 2 0 NTPase Gtr1_RagA PF04670.12 AIF84894.1 - 0.13 11.6 0.0 0.35 10.2 0.0 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region FBPase_3 PF01950.16 AIF84895.1 - 1.3e-150 501.6 0.0 1.4e-150 501.5 0.0 1.0 1 0 0 1 1 1 1 Fructose-1,6-bisphosphatase LBP_M PF17385.2 AIF84895.1 - 0.11 12.0 0.1 0.18 11.3 0.1 1.3 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase central domain TIM PF00121.18 AIF84896.1 - 3.6e-08 33.1 0.0 1.2e-07 31.3 0.0 1.7 1 1 1 2 2 2 1 Triosephosphate isomerase ThiG PF05690.14 AIF84896.1 - 2.2e-05 23.9 0.5 4.3e-05 22.9 0.5 1.5 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG IGPS PF00218.21 AIF84896.1 - 0.0019 17.4 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase FMN_dh PF01070.18 AIF84896.1 - 0.012 14.7 1.3 0.018 14.1 0.4 1.7 2 1 0 2 2 2 0 FMN-dependent dehydrogenase Methyltransf_31 PF13847.6 AIF84897.1 - 7.3e-18 64.8 0.2 1.2e-17 64.1 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF84897.1 - 1.7e-13 51.1 0.2 3.9e-13 49.9 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF84897.1 - 2.7e-13 50.4 1.1 5.8e-13 49.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF84897.1 - 1.1e-11 45.4 0.3 4e-11 43.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF84897.1 - 9.2e-10 38.6 0.0 1.7e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AIF84897.1 - 6.3e-08 32.4 0.2 6e-06 25.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_18 PF12847.7 AIF84897.1 - 9.2e-08 32.2 0.0 2e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 AIF84897.1 - 3.4e-07 29.8 0.3 1.4e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 O-methyltransferase domain GCD14 PF08704.10 AIF84897.1 - 5e-07 29.6 0.0 7.3e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Ubie_methyltran PF01209.18 AIF84897.1 - 3e-05 23.5 0.0 4.7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 AIF84897.1 - 5.1e-05 22.8 0.0 7.9e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase CMAS PF02353.20 AIF84897.1 - 6.3e-05 22.4 0.0 9.8e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 AIF84897.1 - 0.00014 22.9 0.1 0.00052 21.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 AIF84897.1 - 0.00047 19.7 0.5 0.0025 17.2 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 AIF84897.1 - 0.0016 18.2 0.1 0.0033 17.1 0.0 1.5 2 0 0 2 2 1 1 Putative RNA methylase family UPF0020 TehB PF03848.14 AIF84897.1 - 0.0046 16.4 0.0 0.0071 15.8 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_15 PF09445.10 AIF84897.1 - 0.024 14.2 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_32 PF13679.6 AIF84897.1 - 0.058 13.4 0.3 0.1 12.6 0.0 1.5 2 0 0 2 2 1 0 Methyltransferase domain PCMT PF01135.19 AIF84897.1 - 0.08 12.7 0.0 0.19 11.4 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0126 PF03458.13 AIF84898.1 - 2.3e-40 136.4 29.0 4.4e-22 77.8 7.8 2.5 2 1 1 3 3 3 2 UPF0126 domain B12D PF06522.11 AIF84898.1 - 0.43 10.4 0.1 0.43 10.4 0.1 2.4 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit PEP-utilizers_C PF02896.18 AIF84899.1 - 3.2e-85 285.8 2.5 4.6e-85 285.3 2.5 1.2 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.19 AIF84899.1 - 2.9e-57 194.4 0.0 6.3e-45 153.9 0.0 3.3 1 1 1 2 2 2 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.23 AIF84899.1 - 5.1e-27 93.4 0.6 3.6e-26 90.7 0.3 2.4 2 0 0 2 2 2 1 PEP-utilising enzyme, mobile domain HpcH_HpaI PF03328.14 AIF84899.1 - 0.012 14.8 0.1 0.022 13.9 0.1 1.4 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family MFS_1 PF07690.16 AIF84900.1 - 9.9e-42 143.1 52.6 8e-41 140.1 50.4 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AIF84900.1 - 5.5e-07 28.8 12.5 5.5e-07 28.8 12.5 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter Methyltransf_11 PF08241.12 AIF84901.1 - 2.9e-24 85.5 0.0 4.9e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF84901.1 - 1e-22 80.6 0.0 1.5e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF84901.1 - 1.6e-22 80.0 0.0 3.2e-22 79.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF84901.1 - 3.9e-19 69.1 0.0 5.4e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF84901.1 - 3.9e-15 55.8 0.0 2.3e-14 53.3 0.0 1.9 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 AIF84901.1 - 4.2e-12 46.7 0.0 9.1e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AIF84901.1 - 2.5e-08 33.7 0.0 3.8e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 AIF84901.1 - 5.8e-07 29.0 0.0 7.9e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain NodS PF05401.11 AIF84901.1 - 3.7e-06 26.7 0.0 5.4e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) PCMT PF01135.19 AIF84901.1 - 4.5e-06 26.6 0.0 7.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 AIF84901.1 - 1.3e-05 24.4 0.0 2.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase UPF0020 PF01170.18 AIF84901.1 - 3.1e-05 23.8 0.0 0.00036 20.3 0.0 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 DREV PF05219.12 AIF84901.1 - 6.9e-05 22.1 0.0 0.0001 21.5 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase MetW PF07021.12 AIF84901.1 - 7.6e-05 22.4 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 AIF84901.1 - 0.00069 19.1 0.0 0.0045 16.4 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 AIF84901.1 - 0.00069 19.2 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_32 PF13679.6 AIF84901.1 - 0.0037 17.3 0.0 0.0077 16.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 AIF84901.1 - 0.0064 16.0 0.0 0.016 14.7 0.0 1.8 1 0 0 1 1 1 1 Putative methyltransferase CMAS PF02353.20 AIF84901.1 - 0.0073 15.6 0.0 0.0083 15.4 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 AIF84901.1 - 0.011 15.2 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_18 PF12847.7 AIF84901.1 - 0.017 15.0 0.0 0.035 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain GCM PF03615.15 AIF84901.1 - 0.04 13.8 0.0 0.063 13.2 0.0 1.3 1 0 0 1 1 1 0 GCM motif protein MethyltransfD12 PF02086.15 AIF84901.1 - 0.12 12.0 0.7 1.7 8.3 0.0 2.1 1 1 1 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase DNA_RNApol_7kD PF03604.13 AIF84902.1 - 1.3e-05 24.8 2.7 2.4e-05 23.9 2.7 1.4 1 1 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit zf-Mss51 PF13824.6 AIF84902.1 - 0.021 14.9 0.1 0.037 14.1 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Glycos_transf_1 PF00534.20 AIF84902.1 - 0.033 13.7 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF1451 PF07295.11 AIF84902.1 - 0.071 13.1 0.5 0.073 13.1 0.5 1.0 1 0 0 1 1 1 0 Zinc-ribbon containing domain Glyco_trans_1_4 PF13692.6 AIF84902.1 - 0.074 13.5 0.0 0.074 13.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferases group 1 zf_UBZ PF18439.1 AIF84902.1 - 0.19 11.4 0.1 0.3 10.7 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 AIF84903.1 - 3.8e-08 33.4 5.4 0.00052 20.3 1.1 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF84903.1 - 1.3e-06 28.7 5.6 0.011 16.5 0.1 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 AIF84903.1 - 0.00023 21.2 5.9 0.059 13.5 0.4 2.2 2 0 0 2 2 2 2 Zinc ribbon domain zf_UBZ PF18439.1 AIF84903.1 - 0.00088 18.8 4.9 0.3 10.7 1.4 2.3 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger zf_C2H2_ZHX PF18387.1 AIF84903.1 - 0.0016 18.0 1.7 0.088 12.5 0.1 2.1 1 1 1 2 2 2 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_3rep PF18868.1 AIF84903.1 - 0.005 17.5 3.3 1.6 9.4 0.4 2.1 1 1 1 2 2 2 2 Zinc finger C2H2-type, 3 repeats HNH PF01844.23 AIF84903.1 - 0.0073 16.5 3.1 1.7 8.9 0.1 2.2 2 0 0 2 2 2 2 HNH endonuclease zf-H2C2_2 PF13465.6 AIF84903.1 - 0.0078 16.6 11.8 0.27 11.7 0.1 2.8 3 0 0 3 3 3 2 Zinc-finger double domain GATA PF00320.27 AIF84903.1 - 0.01 15.4 0.9 1.3 8.6 0.1 2.3 2 0 0 2 2 2 0 GATA zinc finger Actin_micro PF17003.5 AIF84903.1 - 0.019 14.2 7.2 0.03 13.5 7.2 1.4 1 1 0 1 1 1 0 Putative actin-like family zf-CW PF07496.15 AIF84903.1 - 0.032 14.2 0.8 0.046 13.7 0.8 1.3 1 0 0 1 1 1 0 CW-type Zinc Finger zf-C2H2_8 PF15909.5 AIF84903.1 - 0.05 13.9 1.7 0.09 13.1 1.7 1.5 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_2 PF12756.7 AIF84903.1 - 0.056 13.8 9.7 1.2 9.5 1.6 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_2 PF13240.6 AIF84903.1 - 0.058 13.1 3.7 4.4 7.1 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 AIF84903.1 - 0.062 13.0 3.1 3.3 7.5 0.4 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf-C2HC_2 PF13913.6 AIF84903.1 - 0.069 13.1 5.9 0.071 13.0 0.9 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DUF983 PF06170.12 AIF84903.1 - 0.074 13.5 1.9 0.82 10.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) DZR PF12773.7 AIF84903.1 - 0.1 12.7 3.8 0.17 11.9 3.8 1.4 1 1 0 1 1 1 0 Double zinc ribbon PhnA_Zn_Ribbon PF08274.12 AIF84903.1 - 0.11 12.5 1.7 0.84 9.6 0.1 2.1 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zf-C2H2_jaz PF12171.8 AIF84903.1 - 0.11 12.8 8.4 2.6 8.4 3.0 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding TF_Zn_Ribbon PF08271.12 AIF84903.1 - 0.14 11.7 2.6 1.4 8.5 2.6 2.1 1 1 0 1 1 1 0 TFIIB zinc-binding FYVE PF01363.21 AIF84903.1 - 0.15 12.3 6.0 0.29 11.3 5.3 1.8 1 1 1 2 2 2 0 FYVE zinc finger DUF629 PF04780.12 AIF84903.1 - 0.17 10.4 6.9 0.44 9.0 2.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) ARS2 PF04959.13 AIF84903.1 - 0.17 12.2 6.3 0.22 11.9 6.3 1.2 1 0 0 1 1 1 0 Arsenite-resistance protein 2 CpXC PF14353.6 AIF84903.1 - 0.18 11.9 3.3 2.5 8.1 3.3 2.2 1 1 0 1 1 1 0 CpXC protein OrfB_Zn_ribbon PF07282.11 AIF84903.1 - 0.22 11.5 4.7 0.5 10.3 4.7 1.6 1 1 0 1 1 1 0 Putative transposase DNA-binding domain XPA_N PF01286.18 AIF84903.1 - 0.27 11.3 5.6 2.4 8.3 1.7 2.3 2 0 0 2 2 2 0 XPA protein N-terminal Lar_restr_allev PF14354.6 AIF84903.1 - 0.28 11.6 5.1 0.61 10.5 5.1 1.6 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-Mss51 PF13824.6 AIF84903.1 - 0.3 11.2 7.6 0.64 10.2 2.0 2.4 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf_C2H2_13 PF18508.1 AIF84903.1 - 0.95 9.1 5.8 7.2 6.3 0.9 2.3 1 1 1 2 2 2 0 Zinc finger domain TFIIS_C PF01096.18 AIF84903.1 - 2.8 7.9 8.3 2.8 7.9 0.9 2.4 2 1 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-C4pol PF14260.6 AIF84904.1 - 0.0002 21.8 7.1 0.59 10.6 0.2 3.1 2 1 1 3 3 3 2 C4-type zinc-finger of DNA polymerase delta Cytochrome_C7 PF14522.6 AIF84904.1 - 0.0018 18.2 9.7 0.065 13.2 8.2 2.9 2 1 0 2 2 2 1 Cytochrome c7 and related cytochrome c DUF4428 PF14471.6 AIF84904.1 - 0.0024 17.8 14.5 0.17 11.8 0.8 4.2 3 3 0 3 3 3 2 Domain of unknown function (DUF4428) Cytochrom_c3_2 PF14537.6 AIF84904.1 - 0.0067 16.9 10.4 0.023 15.2 8.5 2.5 2 1 0 2 2 2 1 Cytochrome c3 DUF1451 PF07295.11 AIF84904.1 - 0.02 14.9 1.3 0.02 14.9 1.3 2.3 1 1 0 2 2 2 0 Zinc-ribbon containing domain DZR PF12773.7 AIF84904.1 - 0.027 14.5 17.6 0.76 9.9 4.8 3.6 1 1 1 2 2 2 0 Double zinc ribbon LIM PF00412.22 AIF84904.1 - 0.067 13.4 13.6 0.99 9.7 0.2 3.5 3 1 0 3 3 3 0 LIM domain ZZ PF00569.17 AIF84904.1 - 0.07 13.0 0.3 0.07 13.0 0.3 4.1 5 1 0 5 5 5 0 Zinc finger, ZZ type Zn_ribbon_recom PF13408.6 AIF84904.1 - 0.081 13.5 11.4 1.7 9.2 2.2 2.7 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain Vps39_2 PF10367.9 AIF84904.1 - 0.1 13.1 0.6 0.1 13.1 0.6 2.0 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 zf-NADH-PPase PF09297.11 AIF84904.1 - 0.11 12.1 0.3 0.11 12.1 0.3 4.0 5 0 0 5 5 4 0 NADH pyrophosphatase zinc ribbon domain Ribosomal_S14 PF00253.21 AIF84904.1 - 0.56 10.0 4.5 1.5 8.6 0.6 3.1 3 1 0 3 3 3 0 Ribosomal protein S14p/S29e DUF983 PF06170.12 AIF84904.1 - 0.67 10.4 3.0 14 6.2 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF983) zf-UDP PF14569.6 AIF84904.1 - 0.97 9.6 8.9 0.55 10.4 1.1 3.1 3 2 0 3 3 3 0 Zinc-binding RING-finger Methyltransf_13 PF08421.11 AIF84904.1 - 1.8 8.8 10.3 9.9 6.5 0.6 3.9 3 1 1 4 4 4 0 Putative zinc binding domain RecO_C PF02565.15 AIF84904.1 - 1.9 8.3 5.6 6 6.7 0.2 2.8 2 1 1 3 3 3 0 Recombination protein O C terminal P-II PF00543.22 AIF84905.1 - 7.1e-17 61.9 0.3 8.2e-17 61.7 0.3 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF1326 PF07040.11 AIF84908.1 - 2.2e-49 167.9 0.0 2.5e-49 167.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) P-II PF00543.22 AIF84909.1 - 5.3e-19 68.7 0.1 6.4e-19 68.5 0.1 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II Fil_haemagg PF05594.14 AIF84910.1 - 0.045 14.3 23.7 3.9e+02 1.7 23.7 3.1 1 1 0 1 1 1 0 Haemagluttinin repeat adh_short_C2 PF13561.6 AIF84911.1 - 8.9e-66 221.8 0.9 1e-65 221.6 0.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 AIF84911.1 - 7.3e-57 192.0 2.0 8.7e-57 191.7 2.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AIF84911.1 - 1.7e-10 41.1 0.3 2.5e-10 40.6 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AIF84911.1 - 3e-08 33.4 0.2 1.3e-07 31.4 0.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 AIF84911.1 - 2.4e-06 27.6 2.1 3.6e-06 27.0 1.9 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 AIF84911.1 - 3.4e-06 27.3 0.4 5.9e-06 26.6 0.4 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 AIF84911.1 - 2.8e-05 23.4 0.6 4e-05 22.9 0.6 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 AIF84911.1 - 0.00016 21.7 0.9 0.00038 20.5 0.6 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 AIF84911.1 - 0.00019 22.0 1.6 0.00038 21.0 1.6 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 AIF84911.1 - 0.00027 20.4 0.3 0.0026 17.2 0.3 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 AIF84911.1 - 0.00097 18.2 0.2 0.0014 17.7 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 AIF84911.1 - 0.0011 19.2 0.5 0.002 18.4 0.5 1.4 1 0 0 1 1 1 1 TrkA-N domain 3HCDH_N PF02737.18 AIF84911.1 - 0.0025 17.7 1.0 0.0037 17.2 1.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 AIF84911.1 - 0.0029 17.2 0.2 0.0046 16.6 0.2 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NmrA PF05368.13 AIF84911.1 - 0.0082 15.7 1.4 0.067 12.7 0.9 2.1 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 AIF84911.1 - 0.012 14.7 0.8 0.025 13.8 0.8 1.5 1 1 0 1 1 1 0 Male sterility protein DUF3842 PF12953.7 AIF84911.1 - 0.016 15.6 2.5 0.025 15.0 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3842) RmlD_sub_bind PF04321.17 AIF84911.1 - 0.023 13.8 0.3 0.071 12.2 0.1 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain NAD_binding_7 PF13241.6 AIF84911.1 - 0.093 13.2 0.3 0.17 12.3 0.3 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 AIF84911.1 - 0.11 11.9 0.2 0.17 11.2 0.2 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DHHA1 PF02272.19 AIF84912.1 - 0.00012 22.4 0.0 0.00024 21.6 0.0 1.5 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.20 AIF84912.1 - 0.00076 19.7 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 DHH family HAD_2 PF13419.6 AIF84913.1 - 5e-27 95.1 0.1 6.1e-27 94.8 0.1 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AIF84913.1 - 8.9e-15 55.5 1.9 1.1e-13 51.9 1.9 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AIF84913.1 - 7.2e-05 23.3 0.0 9.8e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AIF84913.1 - 0.007 16.4 0.0 0.023 14.8 0.0 1.9 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 AIF84913.1 - 0.083 13.0 0.2 2.3 8.4 0.2 3.0 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase tRNA-synt_1f PF01921.18 AIF84916.1 - 4.3e-106 354.9 0.0 5.6e-106 354.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (K) tRNA-synt_1 PF00133.22 AIF84916.1 - 0.13 10.5 0.0 0.2 9.9 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) Radical_SAM_C PF16199.5 AIF84917.1 - 5e-25 87.3 0.2 9.3e-25 86.5 0.2 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 AIF84917.1 - 1.4e-23 84.1 0.0 3.7e-23 82.7 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 AIF84917.1 - 1.3e-10 41.5 0.2 3.1e-10 40.3 0.2 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AIF84917.1 - 5.3e-05 23.2 0.1 0.00017 21.5 0.1 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AIRS_C PF02769.22 AIF84918.1 - 1.6e-21 77.1 0.0 3.1e-21 76.1 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 AIF84918.1 - 2.5e-16 60.1 1.4 4.8e-16 59.2 1.4 1.5 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain DUF190 PF02641.15 AIF84919.1 - 1.4e-22 79.8 0.0 1.6e-22 79.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1993 UreD PF01774.17 AIF84922.1 - 9.8e-44 149.8 0.0 1.2e-43 149.5 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein cobW PF02492.19 AIF84923.1 - 2.6e-31 108.6 0.0 3.1e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 AIF84923.1 - 4.4e-09 35.7 0.9 1e-08 34.5 0.9 1.6 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 AIF84923.1 - 8e-05 22.5 0.1 0.00019 21.3 0.1 1.7 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 AIF84923.1 - 0.0037 17.2 0.0 0.0071 16.3 0.0 1.5 1 0 0 1 1 1 1 NTPase Mg_chelatase PF01078.21 AIF84923.1 - 0.015 14.7 0.0 0.021 14.2 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 AIF84923.1 - 0.053 14.0 0.0 0.072 13.6 0.0 1.2 1 0 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.27 AIF84923.1 - 0.073 12.6 0.1 10 5.6 0.0 2.8 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 AIF84923.1 - 0.12 12.7 0.0 1.2 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain LpxK PF02606.14 AIF84923.1 - 0.15 11.1 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase PRK PF00485.18 AIF84923.1 - 0.16 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family UreF PF01730.16 AIF84924.1 - 4.3e-23 82.4 0.0 5.6e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 UreF UreE_N PF02814.15 AIF84925.1 - 8.1e-12 44.6 0.1 1.3e-11 43.9 0.1 1.3 1 0 0 1 1 1 1 UreE urease accessory protein, N-terminal domain UreE_C PF05194.12 AIF84925.1 - 2.9e-05 24.5 0.1 6.7e-05 23.3 0.1 1.7 1 1 0 1 1 1 1 UreE urease accessory protein, C-terminal domain GCD14_N PF14801.6 AIF84925.1 - 0.0036 17.1 0.1 0.023 14.5 0.0 2.2 1 1 1 2 2 2 1 tRNA methyltransferase complex GCD14 subunit N-term DUF3203 PF11462.8 AIF84925.1 - 0.1 12.8 0.2 1.5 9.1 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3203) Cpn60_TCP1 PF00118.24 AIF84927.1 - 4.7e-105 352.0 12.0 5.8e-105 351.7 12.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PALP PF00291.25 AIF84927.1 - 0.03 13.7 1.7 3.1 7.1 0.0 2.5 2 1 1 3 3 3 0 Pyridoxal-phosphate dependent enzyme Amidohydro_1 PF01979.20 AIF84928.1 - 5.7e-61 206.7 1.8 8e-61 206.2 1.8 1.1 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 AIF84928.1 - 1.2e-50 170.8 2.1 3.2e-50 169.5 2.1 1.7 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Amidohydro_3 PF07969.11 AIF84928.1 - 1.3e-06 28.2 2.1 1.3e-06 28.2 2.1 2.0 1 1 1 2 2 2 1 Amidohydrolase family Urease_beta PF00699.20 AIF84929.1 - 2.7e-41 139.6 0.0 3.5e-41 139.2 0.0 1.2 1 0 0 1 1 1 1 Urease beta subunit Urease_gamma PF00547.18 AIF84930.1 - 2.2e-43 146.6 0.1 2.4e-43 146.5 0.1 1.0 1 0 0 1 1 1 1 Urease, gamma subunit TrbI_Ftype PF09677.10 AIF84930.1 - 0.002 18.4 0.2 0.03 14.6 0.2 2.0 1 1 1 2 2 2 2 Type-F conjugative transfer system protein (TrbI_Ftype) Svf1_C PF17187.4 AIF84930.1 - 0.029 14.2 0.0 0.033 14.0 0.0 1.1 1 0 0 1 1 1 0 Svf1-like C-terminal lipocalin-like domain UT PF03253.14 AIF84932.1 - 8.2e-51 172.9 38.4 5.3e-21 75.0 11.4 3.0 2 1 1 3 3 3 3 Urea transporter SSF PF00474.17 AIF84933.1 - 1.2e-24 87.0 38.2 1.2e-24 87.0 38.2 1.7 2 0 0 2 2 2 1 Sodium:solute symporter family Usp PF00582.26 AIF84933.1 - 7.5e-23 81.6 0.0 1.4e-22 80.7 0.0 1.4 1 0 0 1 1 1 1 Universal stress protein family HTH_24 PF13412.6 AIF84934.1 - 0.013 15.0 0.3 4.5 6.9 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding ParBc PF02195.18 AIF84935.1 - 1.8e-20 73.0 0.6 4.9e-19 68.4 0.0 2.4 2 0 0 2 2 2 1 ParB-like nuclease domain HTH_ParB PF17762.1 AIF84935.1 - 3.9e-07 29.8 1.6 1.1e-06 28.3 1.6 1.8 1 0 0 1 1 1 1 HTH domain found in ParB protein KorB PF08535.10 AIF84935.1 - 1.4e-05 25.0 0.1 4.6e-05 23.4 0.1 2.0 1 0 0 1 1 1 1 KorB domain GIDA PF01134.22 AIF84935.1 - 0.048 12.7 0.3 0.16 11.0 0.1 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A HTH_5 PF01022.20 AIF84935.1 - 0.076 12.9 1.0 0.91 9.4 0.1 2.8 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family Usp PF00582.26 AIF84937.1 - 1.1e-34 120.0 0.2 1.5e-34 119.5 0.2 1.2 1 0 0 1 1 1 1 Universal stress protein family Pterin_bind PF00809.22 AIF84937.1 - 0.03 14.0 0.1 0.54 9.9 0.1 2.0 1 1 1 2 2 2 0 Pterin binding enzyme Zeta_toxin PF06414.12 AIF84941.1 - 0.099 11.9 0.2 0.19 11.0 0.1 1.4 2 0 0 2 2 2 0 Zeta toxin ApoC-I PF04691.12 AIF84941.1 - 0.28 11.1 2.6 5.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) SSF PF00474.17 AIF84942.1 - 1.2e-29 103.5 28.3 1.2e-29 103.5 28.3 1.4 2 0 0 2 2 2 1 Sodium:solute symporter family ParBc PF02195.18 AIF84944.1 - 2.2e-10 40.7 0.0 5e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 ParB-like nuclease domain HTH_23 PF13384.6 AIF84944.1 - 0.0045 16.8 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 AIF84944.1 - 0.036 14.2 0.0 0.1 12.8 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain CENP-B_N PF04218.13 AIF84944.1 - 0.037 13.7 0.0 0.095 12.4 0.0 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_IclR PF09339.10 AIF84944.1 - 0.17 11.7 0.3 0.47 10.3 0.0 1.9 2 0 0 2 2 2 0 IclR helix-turn-helix domain Arginase PF00491.21 AIF84945.1 - 2.6e-76 256.8 0.0 3e-76 256.6 0.0 1.0 1 0 0 1 1 1 1 Arginase family Urease_gamma PF00547.18 AIF84946.1 - 5.7e-13 49.0 0.1 7.3e-13 48.7 0.1 1.1 1 0 0 1 1 1 1 Urease, gamma subunit NicO PF03824.16 AIF84947.1 - 2.5e-18 66.4 20.5 4.8e-16 58.9 20.5 2.1 1 1 0 1 1 1 1 High-affinity nickel-transport protein Peptidase_S28 PF05577.12 AIF84947.1 - 0.16 10.7 0.0 0.24 10.1 0.0 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 NikR_C PF08753.11 AIF84948.1 - 1.9e-25 88.8 3.8 1.9e-25 88.8 3.8 1.5 2 0 0 2 2 2 1 NikR C terminal nickel binding domain RHH_1 PF01402.21 AIF84948.1 - 0.00093 19.1 1.4 0.016 15.2 0.0 2.2 2 0 0 2 2 2 1 Ribbon-helix-helix protein, copG family Cpn60_TCP1 PF00118.24 AIF84949.1 - 2.8e-144 481.4 11.3 3.2e-144 481.2 11.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Urease_gamma PF00547.18 AIF84950.1 - 1.1e-45 154.0 0.0 1.2e-45 153.8 0.0 1.0 1 0 0 1 1 1 1 Urease, gamma subunit Urease_beta PF00699.20 AIF84951.1 - 7.7e-40 134.9 0.0 9.1e-40 134.6 0.0 1.1 1 0 0 1 1 1 1 Urease beta subunit Amidohydro_1 PF01979.20 AIF84952.1 - 4.4e-79 266.3 0.3 5.9e-79 265.9 0.3 1.1 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 AIF84952.1 - 7.1e-40 136.1 3.6 1.4e-39 135.1 3.6 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Amidohydro_3 PF07969.11 AIF84952.1 - 1.4e-06 28.1 1.7 0.00012 21.7 0.1 2.4 1 1 0 2 2 2 2 Amidohydrolase family Dioxygenase_C PF00775.21 AIF84954.1 - 1.6e-12 47.2 0.0 2.5e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase MFS_2 PF13347.6 AIF84954.1 - 0.047 12.2 2.3 0.063 11.8 2.3 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein Citrate_synt PF00285.21 AIF84955.1 - 2.3e-123 411.9 0.0 2.6e-123 411.6 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Bac_luciferase PF00296.20 AIF84957.1 - 4e-59 200.6 0.0 5e-59 200.3 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Lactamase_B_3 PF13483.6 AIF84958.1 - 0.00014 21.8 0.1 0.00079 19.4 0.0 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 AIF84958.1 - 0.003 17.1 0.6 0.16 11.4 0.3 2.8 2 1 0 3 3 3 1 Beta-lactamase superfamily domain RMMBL PF07521.12 AIF84958.1 - 0.052 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 AIF84958.1 - 0.32 11.0 1.9 1.8 8.5 0.7 2.3 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Formyl_trans_N PF00551.19 AIF84959.1 - 1.3e-49 168.4 0.0 1.4e-49 168.3 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase MFS_1 PF07690.16 AIF84960.1 - 6.9e-35 120.6 48.8 2.7e-24 85.7 12.6 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 AIF84960.1 - 3.3e-14 53.0 32.1 4.2e-14 52.6 32.1 1.0 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 AIF84960.1 - 1.1e-06 27.8 25.6 2e-05 23.7 6.1 2.9 2 1 1 3 3 3 2 MFS_1 like family UNC-93 PF05978.16 AIF84960.1 - 0.0018 18.0 3.8 0.0018 18.0 3.8 2.4 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 MASE2 PF05230.11 AIF84960.1 - 0.029 14.4 1.0 0.029 14.4 1.0 3.3 2 0 0 2 2 2 0 MASE2 domain MFS_3 PF05977.13 AIF84960.1 - 0.068 11.6 24.7 0.11 10.9 24.7 1.3 1 1 0 1 1 1 0 Transmembrane secretion effector OATP PF03137.20 AIF84960.1 - 1.3 7.2 9.8 0.13 10.5 0.9 2.9 2 2 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Pam17 PF08566.10 AIF84960.1 - 3.1 7.6 6.6 2.1 8.2 0.2 2.7 2 1 1 3 3 3 0 Mitochondrial import protein Pam17 Ubie_methyltran PF01209.18 AIF84961.1 - 2.3e-21 76.2 0.0 2.6e-21 76.0 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 AIF84961.1 - 7.4e-16 58.6 0.0 1.3e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF84961.1 - 1.1e-15 58.1 0.0 2.1e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF84961.1 - 5.3e-11 42.5 0.0 7.7e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF84961.1 - 4.4e-09 37.0 0.0 7.8e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF84961.1 - 9.2e-08 32.1 0.0 1.1e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 AIF84961.1 - 0.0037 17.1 0.0 0.0055 16.6 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 AIF84961.1 - 0.034 13.7 0.0 0.091 12.3 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain DEAD PF00270.29 AIF84962.1 - 9.4e-32 110.2 0.0 2.1e-31 109.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AIF84962.1 - 6.7e-13 49.0 0.0 1.4e-09 38.3 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DUF1998 PF09369.10 AIF84962.1 - 2.2e-10 41.2 0.2 1.1e-09 39.0 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1998) zinc_ribbon_4 PF13717.6 AIF84962.1 - 0.0081 16.1 1.1 0.0081 16.1 1.1 2.3 2 0 0 2 2 2 1 zinc-ribbon domain SNF2_N PF00176.23 AIF84962.1 - 0.19 10.4 0.0 0.3 9.7 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain Topoisom_I_N PF02919.15 AIF84963.1 - 8.9e-65 218.2 0.9 8.9e-65 218.2 0.9 2.1 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 AIF84963.1 - 4e-64 216.0 4.4 4e-64 216.0 4.4 1.7 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 AIF84963.1 - 4.7e-21 74.5 2.7 9.3e-21 73.5 1.1 2.4 2 0 0 2 2 2 1 C-terminal topoisomerase domain Sipho_tail PF05709.11 AIF84963.1 - 0.093 12.1 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 Phage tail protein DUF4226 PF10774.9 AIF84963.1 - 0.38 11.0 5.5 0.19 12.0 2.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4226) Coiled-coil_56 PF09813.9 AIF84963.1 - 1.9 8.6 5.8 0.82 9.7 1.7 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 AAA_23 PF13476.6 AIF84963.1 - 3.1 8.3 21.2 0.13 12.7 7.7 2.7 2 1 0 2 2 2 0 AAA domain MarR_2 PF12802.7 AIF84964.1 - 4.9e-05 23.1 0.1 0.00013 21.7 0.1 1.7 1 0 0 1 1 1 1 MarR family TPR_12 PF13424.6 AIF84964.1 - 0.00098 19.4 1.5 0.13 12.5 0.7 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat HTH_IclR PF09339.10 AIF84964.1 - 0.0026 17.5 0.0 0.0066 16.2 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 AIF84964.1 - 0.013 15.3 0.0 0.031 14.2 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 AIF84964.1 - 0.015 14.8 0.0 0.032 13.8 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TPR_2 PF07719.17 AIF84964.1 - 0.017 15.2 0.5 1.5 9.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 AIF84964.1 - 0.017 15.7 5.0 0.14 12.8 0.4 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat HTH_20 PF12840.7 AIF84964.1 - 0.086 12.9 0.3 0.26 11.4 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain MIT PF04212.18 AIF84964.1 - 0.2 11.8 0.7 19 5.4 0.0 2.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain DUF4366 PF14283.6 AIF84964.1 - 0.34 11.0 1.2 0.53 10.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) CBS PF00571.28 AIF84965.1 - 2.4e-17 63.1 3.0 9.5e-08 32.4 0.3 2.3 2 0 0 2 2 2 2 CBS domain zf-C2H2_4 PF13894.6 AIF84965.1 - 0.00043 20.9 0.1 0.001 19.7 0.1 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIF84965.1 - 0.00053 20.3 0.1 0.0011 19.4 0.1 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-Di19 PF05605.12 AIF84965.1 - 0.012 15.9 0.0 0.027 14.8 0.0 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 AIF84965.1 - 0.017 14.9 0.1 0.041 13.7 0.0 1.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf_C2H2_6 PF18450.1 AIF84965.1 - 0.068 12.9 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Zinc Finger domain fn3 PF00041.21 AIF84966.1 - 0.015 15.6 1.6 0.14 12.6 1.6 2.1 1 1 0 1 1 1 0 Fibronectin type III domain Prok-JAB PF14464.6 AIF84966.1 - 0.052 13.3 0.0 0.062 13.1 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic homologs of the JAB domain Aida_C2 PF14186.6 AIF84966.1 - 0.053 13.1 0.2 0.15 11.7 0.1 1.7 1 1 1 2 2 2 0 Cytoskeletal adhesion DUF1573 PF07610.11 AIF84966.1 - 0.064 13.3 0.3 12 6.1 0.0 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1573) Flu_PB2 PF00604.17 AIF84966.1 - 0.12 10.2 0.0 0.14 10.0 0.0 1.0 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB2 Tissue_fac PF01108.17 AIF84966.1 - 0.16 11.8 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Tissue factor Lyase_1 PF00206.20 AIF84967.1 - 4.9e-44 151.0 1.6 6.2e-44 150.6 0.1 1.8 2 0 0 2 2 2 1 Lyase ADSL_C PF10397.9 AIF84967.1 - 2.3e-14 53.7 0.1 6.5e-14 52.2 0.1 1.9 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus ABM PF03992.16 AIF84968.1 - 0.0076 16.3 0.1 0.026 14.7 0.1 1.8 1 1 0 1 1 1 1 Antibiotic biosynthesis monooxygenase RtcB PF01139.17 AIF84969.1 - 5.2e-162 539.7 0.0 6e-162 539.5 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Complex1_LYR PF05347.15 AIF84969.1 - 0.16 12.0 0.2 0.34 11.0 0.2 1.5 1 0 0 1 1 1 0 Complex 1 protein (LYR family) dsDNA_bind PF01984.20 AIF84970.1 - 1.7e-05 25.1 0.2 2e-05 24.8 0.2 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Ribosomal_S11 PF00411.19 AIF84972.1 - 5.7e-44 149.0 1.4 6.6e-44 148.8 1.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S11 Methyltransf_11 PF08241.12 AIF84973.1 - 9.2e-13 48.7 0.0 3.2e-12 46.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF84973.1 - 8.2e-10 39.3 0.0 1.7e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF84973.1 - 4.7e-06 26.5 0.0 6.5e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF84973.1 - 0.0046 17.7 0.0 0.0073 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF84973.1 - 0.021 14.6 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain HATPase_c PF02518.26 AIF84976.1 - 4.6e-21 75.4 0.2 1.1e-20 74.2 0.1 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIF84976.1 - 1.1e-13 51.0 0.1 2.8e-13 49.7 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 AIF84976.1 - 1.1e-10 41.7 0.0 2.5e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 AIF84976.1 - 1.5e-05 25.2 0.0 4.9e-05 23.5 0.0 1.9 1 1 1 2 2 2 1 PAS fold PAS PF00989.25 AIF84976.1 - 0.00075 19.5 0.0 0.0022 18.0 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 AIF84976.1 - 0.013 15.5 0.0 0.035 14.1 0.0 1.7 1 0 0 1 1 1 0 PAS domain PAS_3 PF08447.12 AIF84976.1 - 0.073 13.4 0.0 0.22 11.8 0.0 1.8 2 0 0 2 2 2 0 PAS fold Response_reg PF00072.24 AIF84977.1 - 2e-15 56.9 0.1 2.8e-15 56.4 0.1 1.2 1 0 0 1 1 1 1 Response regulator receiver domain FlaC_arch PF05377.11 AIF84977.1 - 0.032 14.6 0.7 2.9 8.4 0.4 2.4 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF1514 PF07438.11 AIF84977.1 - 0.16 11.9 0.3 1.1 9.1 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1514) SfLAP PF11139.8 AIF84979.1 - 0.0012 18.3 4.0 0.0015 18.0 4.0 1.2 1 0 0 1 1 1 1 Sap, sulfolipid-1-addressing protein AIRS PF00586.24 AIF84981.1 - 5e-18 65.5 0.9 1.1e-17 64.4 0.3 1.9 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.22 AIF84981.1 - 5.3e-08 33.1 0.2 8.5e-08 32.5 0.2 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain PGM_PMM_I PF02878.16 AIF84982.1 - 3.7e-24 85.0 0.0 9.7e-24 83.6 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 AIF84982.1 - 2.8e-17 63.0 0.1 6.2e-17 61.8 0.1 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 AIF84982.1 - 4e-16 59.5 0.1 8.1e-16 58.5 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 AIF84982.1 - 1.3e-06 28.5 0.0 4.2e-06 26.8 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain P-II PF00543.22 AIF84983.1 - 8.2e-18 64.9 0.7 1.2e-17 64.4 0.7 1.2 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II RsgI_N PF12791.7 AIF84984.1 - 0.089 12.7 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Anti-sigma factor N-terminus Cpn60_TCP1 PF00118.24 AIF84985.1 - 4e-179 596.3 16.1 4.6e-179 596.1 16.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-C2H2_4 PF13894.6 AIF84987.1 - 0.001 19.7 2.3 0.0014 19.2 2.3 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf_UBZ PF18439.1 AIF84987.1 - 0.0033 17.0 0.4 0.0048 16.5 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 AIF84987.1 - 0.005 16.9 0.6 0.0057 16.8 0.6 1.1 1 0 0 1 1 1 1 Zinc ribbon domain zf_C2H2_ZHX PF18387.1 AIF84987.1 - 0.011 15.4 0.4 0.012 15.2 0.4 1.1 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2 PF00096.26 AIF84987.1 - 0.012 16.1 1.6 0.017 15.6 1.6 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type Sel_put PF04328.13 AIF84987.1 - 0.017 15.1 0.1 0.019 15.0 0.1 1.2 1 0 0 1 1 1 0 Selenoprotein, putative zf-C2H2_8 PF15909.5 AIF84987.1 - 0.043 14.1 0.1 0.047 14.0 0.1 1.1 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 AIF84987.1 - 0.31 11.1 5.1 0.46 10.5 5.1 1.4 1 1 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AIF84989.1 - 9.4e-05 22.3 0.3 0.00018 21.4 0.3 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 AIF84989.1 - 0.012 16.4 1.1 0.16 12.9 0.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger LEDGF PF11467.8 AIF84989.1 - 0.035 13.7 0.0 0.22 11.1 0.0 2.1 2 0 0 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) zf-AD PF07776.15 AIF84989.1 - 0.043 14.0 0.0 0.07 13.4 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) zf-C2H2 PF00096.26 AIF84989.1 - 0.12 12.9 0.4 0.33 11.5 0.2 1.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type MotCF PF09158.10 AIF84989.1 - 0.2 11.7 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage T4 MotA, C-terminal NitrOD2 PF18550.1 AIF84993.1 - 8.1e-37 125.5 0.3 1e-36 125.2 0.3 1.1 1 0 0 1 1 1 1 Nitrososphaera output domain 2 MarC PF01914.17 AIF84994.1 - 2.4e-45 154.5 16.0 3.2e-45 154.0 16.0 1.2 1 0 0 1 1 1 1 MarC family integral membrane protein DUF5134 PF17197.4 AIF84994.1 - 1.3 8.9 6.7 3.2 7.6 6.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5134) DUF3185 PF11381.8 AIF84997.1 - 0.09 12.8 5.4 1.7 8.8 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) Hanta_G1 PF01567.16 AIF84997.1 - 0.13 11.0 2.2 0.14 10.8 2.2 1.0 1 0 0 1 1 1 0 Hantavirus glycoprotein G1 Myco_19_kDa PF05481.12 AIF84998.1 - 0.0085 16.4 0.1 0.0085 16.4 0.1 2.3 2 0 0 2 2 2 1 Mycobacterium 19 kDa lipoprotein antigen Claudin_2 PF13903.6 AIF84999.1 - 0.013 15.2 0.3 0.016 15.0 0.3 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Lung_7-TM_R PF06814.13 AIF84999.1 - 0.036 13.3 0.0 0.042 13.1 0.0 1.0 1 0 0 1 1 1 0 Lung seven transmembrane receptor CrgA PF06781.12 AIF84999.1 - 0.11 12.5 0.1 0.14 12.3 0.1 1.2 1 0 0 1 1 1 0 Cell division protein CrgA COX4 PF02936.14 AIF84999.1 - 0.21 11.6 0.0 0.25 11.4 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV SecE PF00584.20 AIF84999.1 - 0.34 10.9 3.4 0.75 9.8 3.4 1.7 1 1 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex Phage_holin_3_6 PF07332.11 AIF85000.1 - 0.054 13.5 5.5 0.061 13.4 5.5 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3789 PF12664.7 AIF85000.1 - 1.3 8.8 6.8 8.6 6.2 6.8 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3789) DUF2207 PF09972.9 AIF85000.1 - 5.4 5.7 5.0 5.6 5.6 5.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PEP-utilisers_N PF05524.13 AIF85001.1 - 0.024 14.8 0.3 0.15 12.2 0.2 1.9 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal Ribosomal_S30AE PF02482.19 AIF85001.1 - 0.13 13.1 0.1 0.16 12.8 0.1 1.2 1 1 0 1 1 1 0 Sigma 54 modulation protein / S30EA ribosomal protein SAP PF02037.27 AIF85001.1 - 0.62 9.9 2.9 0.39 10.5 1.2 1.6 2 0 0 2 2 2 0 SAP domain IATP PF04568.12 AIF85002.1 - 0.0035 17.7 5.4 0.0035 17.7 5.4 2.1 2 1 1 3 3 3 1 Mitochondrial ATPase inhibitor, IATP HEAT_2 PF13646.6 AIF85002.1 - 0.025 15.0 0.2 0.034 14.5 0.2 1.2 1 0 0 1 1 1 0 HEAT repeats DUF4364 PF14277.6 AIF85002.1 - 0.081 12.7 0.6 0.14 11.9 0.1 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4364) DUF2201_N PF13203.6 AIF85002.1 - 0.19 11.3 3.4 0.21 11.2 3.4 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain RNA_pol_Rpc4 PF05132.14 AIF85002.1 - 0.47 10.9 6.3 0.54 10.7 6.3 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 MCLC PF05934.11 AIF85002.1 - 2.8 6.6 6.6 3.3 6.3 6.6 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Presenilin PF01080.17 AIF85002.1 - 5.9 5.6 4.9 6 5.5 4.9 1.1 1 0 0 1 1 1 0 Presenilin CitMHS PF03600.16 AIF85003.1 - 3.3e-38 131.6 33.4 3.3e-38 131.6 33.4 1.6 1 1 1 2 2 2 1 Citrate transporter ADH_N PF08240.12 AIF85004.1 - 6.8e-28 96.7 2.2 6.8e-28 96.7 2.2 1.5 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIF85004.1 - 1.7e-20 73.3 1.3 1.7e-20 73.3 1.3 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 AIF85004.1 - 0.00029 20.2 0.1 0.00053 19.4 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 AIF85004.1 - 0.0024 17.2 2.3 0.0037 16.6 1.7 1.4 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain CoA_binding PF02629.19 AIF85004.1 - 0.011 16.4 0.4 0.031 14.9 0.4 1.8 1 0 0 1 1 1 0 CoA binding domain ELFV_dehydrog PF00208.21 AIF85004.1 - 0.014 15.1 0.3 0.023 14.4 0.3 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NUDIX PF00293.28 AIF85005.1 - 7.1e-18 64.9 0.0 9.4e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain TrmB PF01978.19 AIF85006.1 - 0.0044 16.9 0.7 0.0075 16.1 0.1 1.7 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB LexA_DNA_bind PF01726.16 AIF85006.1 - 0.0065 16.2 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 LexA DNA binding domain HTH_IclR PF09339.10 AIF85006.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain PrgI PF12666.7 AIF85006.1 - 8.8 7.1 7.6 0.52 11.1 0.6 2.4 3 0 0 3 3 3 0 PrgI family protein MgtC PF02308.16 AIF85008.1 - 1.3e-32 112.7 5.9 1.6e-32 112.4 5.9 1.1 1 0 0 1 1 1 1 MgtC family MethyltransfD12 PF02086.15 AIF85009.1 - 5.4e-22 78.7 0.0 1.1e-21 77.7 0.0 1.4 1 1 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Cons_hypoth95 PF03602.15 AIF85009.1 - 0.0052 16.4 0.1 0.012 15.2 0.0 1.6 2 0 0 2 2 2 1 Conserved hypothetical protein 95 TetR_N PF00440.23 AIF85010.1 - 7.7e-16 57.6 0.0 1.3e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.6 AIF85010.1 - 1.3e-07 31.8 0.0 2.5e-07 30.9 0.0 1.5 2 0 0 2 2 2 1 BetI-type transcriptional repressor, C-terminal TetR_C_31 PF17940.1 AIF85010.1 - 0.00011 22.4 0.0 0.00019 21.6 0.0 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_15 PF17918.1 AIF85010.1 - 0.00078 20.2 0.0 0.0054 17.5 0.0 2.2 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_17 PF17922.1 AIF85010.1 - 0.054 13.6 0.0 0.088 12.9 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain tRNA-synt_2 PF00152.20 AIF85011.1 - 8.2e-81 271.5 0.0 9.7e-81 271.2 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AIF85011.1 - 3.2e-10 39.8 0.1 6.2e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti-like PF12869.7 AIF85011.1 - 0.0026 17.4 0.1 0.0045 16.6 0.1 1.3 1 0 0 1 1 1 1 tRNA_anti-like tRNA_anti_2 PF13742.6 AIF85011.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AIF85011.1 - 0.16 11.4 0.0 1.6 8.1 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Pam17 PF08566.10 AIF85012.1 - 7 6.5 6.0 1.8 8.4 1.2 2.0 1 1 1 2 2 2 0 Mitochondrial import protein Pam17 Alba PF01918.21 AIF85013.1 - 0.0054 16.5 0.7 0.013 15.3 0.3 1.8 1 1 1 2 2 2 1 Alba S-methyl_trans PF02574.16 AIF85014.1 - 7.5e-66 222.7 0.0 8.5e-66 222.5 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase PSD2 PF07624.11 AIF85015.1 - 0.076 12.8 0.0 0.27 11.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) DUF1822 PF08852.11 AIF85015.1 - 0.079 12.0 0.0 0.18 10.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1822) CopG_antitoxin PF12441.8 AIF85015.1 - 0.086 13.4 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 CopG antitoxin of type II toxin-antitoxin system Urease_linker PF18473.1 AIF85017.1 - 0.059 13.3 0.2 0.099 12.5 0.2 1.4 1 0 0 1 1 1 0 Urease subunit beta-alpha linker domain Pterin_4a PF01329.19 AIF85018.1 - 6.2e-25 87.2 0.1 1.1e-24 86.4 0.1 1.4 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase DndB PF14072.6 AIF85020.1 - 0.026 13.8 0.0 0.032 13.5 0.0 1.4 1 1 0 1 1 1 0 DNA-sulfur modification-associated Pterin_bind PF00809.22 AIF85021.1 - 5.3e-34 118.0 0.0 9.3e-34 117.2 0.0 1.4 1 0 0 1 1 1 1 Pterin binding enzyme B12-binding_2 PF02607.17 AIF85021.1 - 1.2e-24 86.6 0.6 3e-24 85.3 0.6 1.8 1 0 0 1 1 1 1 B12 binding domain Met_synt_B12 PF02965.17 AIF85021.1 - 4.3e-24 85.4 0.1 1.6e-23 83.6 0.1 2.0 1 1 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain B12-binding PF02310.19 AIF85021.1 - 7.6e-19 67.9 0.0 1.9e-18 66.7 0.0 1.7 1 0 0 1 1 1 1 B12 binding domain CdhD PF03599.16 AIF85021.1 - 5.2e-05 22.1 0.0 0.0001 21.2 0.0 1.4 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit adh_short PF00106.25 AIF85021.1 - 0.0022 17.5 0.2 0.035 13.5 0.1 2.3 2 0 0 2 2 2 1 short chain dehydrogenase Methylase_S PF01420.19 AIF85022.1 - 1.5e-40 139.2 0.2 1.5e-31 109.9 0.0 2.1 2 0 0 2 2 2 2 Type I restriction modification DNA specificity domain N6_Mtase PF02384.16 AIF85023.1 - 9.5e-65 218.9 0.0 2.4e-64 217.6 0.0 1.6 1 1 0 1 1 1 1 N-6 DNA Methylase HsdM_N PF12161.8 AIF85023.1 - 5.8e-17 62.6 0.4 5.8e-17 62.6 0.4 2.3 2 0 0 2 2 2 1 HsdM N-terminal domain UPF0020 PF01170.18 AIF85023.1 - 4.1e-12 46.2 0.0 7.8e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 UBD PF16455.5 AIF85023.1 - 0.032 14.5 0.1 0.089 13.0 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin-binding domain Eco57I PF07669.11 AIF85023.1 - 0.043 14.3 0.0 0.14 12.7 0.0 1.8 1 0 0 1 1 1 0 Eco57I restriction-modification methylase MTS PF05175.14 AIF85023.1 - 0.046 13.3 0.1 0.35 10.4 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase small domain DUF3961 PF13106.6 AIF85023.1 - 0.11 12.1 1.4 13 5.5 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3961) ResIII PF04851.15 AIF85024.1 - 1.6e-33 116.1 0.3 5.7e-33 114.3 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit EcoEI_R_C PF08463.10 AIF85024.1 - 1.3e-21 77.5 4.2 4.4e-21 75.7 4.2 1.9 1 0 0 1 1 1 1 EcoEI R protein C-terminal SWI2_SNF2 PF18766.1 AIF85024.1 - 2.2e-18 66.7 0.1 5.7e-18 65.4 0.1 1.7 1 0 0 1 1 1 1 SWI2/SNF2 ATPase Helicase_C PF00271.31 AIF85024.1 - 1.6e-09 38.1 0.1 2.2e-08 34.4 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSDR_N PF04313.14 AIF85024.1 - 2.4e-08 34.1 5.3 8.8e-08 32.3 0.1 3.6 2 2 0 2 2 2 1 Type I restriction enzyme R protein N terminus (HSDR_N) DEAD PF00270.29 AIF85024.1 - 1.5e-07 31.3 0.0 1.4e-06 28.2 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF2075 PF09848.9 AIF85024.1 - 0.0024 17.2 0.0 0.0058 15.9 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DUF2745 PF10922.8 AIF85024.1 - 0.013 15.7 0.5 0.034 14.4 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2745) HSDR_N_2 PF13588.6 AIF85024.1 - 0.026 14.5 0.0 0.092 12.7 0.0 1.9 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) AAA_19 PF13245.6 AIF85024.1 - 0.1 12.9 0.0 0.58 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain TSC22 PF01166.18 AIF85024.1 - 0.87 9.9 4.0 4.9 7.5 0.1 3.2 2 1 1 3 3 3 0 TSC-22/dip/bun family DUF87 PF01935.17 AIF85024.1 - 1 9.4 8.0 0.88 9.6 0.2 3.4 2 2 1 3 3 3 0 Helicase HerA, central domain DUF16 PF01519.16 AIF85024.1 - 3.5 8.2 7.6 16 6.0 0.5 3.4 3 1 0 3 3 3 0 Protein of unknown function DUF16 TPR_2 PF07719.17 AIF85026.1 - 9.8e-17 59.7 35.0 1.6e-06 27.8 0.6 8.6 8 2 1 9 9 9 4 Tetratricopeptide repeat TPR_1 PF00515.28 AIF85026.1 - 1.3e-16 59.6 36.2 2.7e-05 23.8 1.0 8.3 8 1 1 9 9 8 5 Tetratricopeptide repeat TPR_7 PF13176.6 AIF85026.1 - 1.5e-16 59.1 6.0 0.00052 19.9 0.3 6.6 6 1 0 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 AIF85026.1 - 3.3e-16 58.6 2.4 0.017 15.9 0.0 7.2 2 2 5 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 AIF85026.1 - 9.8e-16 58.0 11.5 2.3e-05 24.8 0.0 5.1 4 1 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 AIF85026.1 - 8.5e-13 47.8 11.8 0.0082 15.8 0.2 7.7 7 0 0 7 7 7 3 TPR repeat TPR_16 PF13432.6 AIF85026.1 - 1.1e-12 48.3 5.7 0.00096 19.8 0.0 6.7 2 1 5 7 7 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 AIF85026.1 - 1.5e-11 44.3 11.3 0.00024 21.3 0.9 3.9 4 1 1 5 5 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 AIF85026.1 - 2.9e-11 42.9 13.3 0.17 12.3 0.1 7.3 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 AIF85026.1 - 3.3e-10 40.1 12.2 0.0054 17.0 0.3 6.5 3 2 1 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 AIF85026.1 - 1e-09 38.4 0.3 0.00067 19.8 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 AIF85026.1 - 1.1e-08 34.6 22.6 0.00091 19.3 0.5 7.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 AIF85026.1 - 3.2e-08 33.7 10.9 0.00079 19.9 0.3 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AIF85026.1 - 2e-06 27.8 19.9 0.016 15.3 0.3 7.3 8 1 1 9 9 7 2 Fis1 C-terminal tetratricopeptide repeat SRP_TPR_like PF17004.5 AIF85026.1 - 2.5e-05 24.3 8.6 0.39 10.7 0.0 3.9 3 2 0 3 3 3 3 Putative TPR-like repeat TPR_15 PF13429.6 AIF85026.1 - 0.00086 18.6 0.1 0.037 13.3 0.0 2.8 1 1 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 AIF85026.1 - 0.0039 17.2 15.1 0.2 11.7 1.3 5.7 4 3 1 6 6 6 1 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 AIF85026.1 - 0.0047 16.8 7.3 8 6.5 0.0 5.5 6 1 1 7 7 6 1 Tetratricopeptide repeat BTAD PF03704.17 AIF85026.1 - 0.0049 17.3 1.4 5.3 7.5 0.0 3.1 3 0 0 3 3 3 2 Bacterial transcriptional activator domain NRBF2_MIT PF17169.4 AIF85026.1 - 0.014 15.6 0.1 2.4 8.4 0.0 3.5 3 1 0 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 PPR PF01535.20 AIF85026.1 - 0.46 10.9 12.0 13 6.3 0.0 5.5 7 1 0 7 7 5 0 PPR repeat RPN7 PF10602.9 AIF85026.1 - 1.6 8.4 4.6 5.8 6.6 0.0 2.9 3 1 0 3 3 3 0 26S proteasome subunit RPN7 Hjc PF01870.18 AIF85028.1 - 0.0017 18.3 0.0 0.0031 17.5 0.0 1.5 1 0 0 1 1 1 1 Archaeal holliday junction resolvase (hjc) MmcB-like PF06319.12 AIF85028.1 - 0.014 15.1 0.1 0.019 14.7 0.1 1.2 1 0 0 1 1 1 0 DNA repair protein MmcB-like AHJR-like PF18743.1 AIF85028.1 - 0.022 14.3 0.1 0.038 13.5 0.1 1.5 1 0 0 1 1 1 0 REase_AHJR-like NERD PF08378.11 AIF85028.1 - 0.034 14.6 0.1 0.057 13.9 0.1 1.5 1 0 0 1 1 1 0 Nuclease-related domain Peptidase_S8 PF00082.22 AIF85029.1 - 9.6e-14 51.3 0.0 1.3e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 Subtilase family Phage_integrase PF00589.22 AIF85030.1 - 1.5e-06 28.1 1.1 3.9e-06 26.8 0.1 2.2 1 1 1 2 2 2 1 Phage integrase family Phage_int_SAM_1 PF02899.17 AIF85030.1 - 0.0069 16.7 0.1 0.021 15.1 0.1 1.8 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 AIF85030.1 - 0.011 16.2 2.3 0.019 15.4 0.2 2.5 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain DUF4771 PF15995.5 AIF85030.1 - 0.26 11.6 4.0 0.51 10.6 1.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4771) Arc_PepC_II PF06847.11 AIF85030.1 - 0.32 11.5 1.1 0.86 10.2 1.1 1.7 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II Neurensin PF14927.6 AIF85031.1 - 0.035 13.8 0.2 2 8.1 0.1 2.2 2 0 0 2 2 2 0 Neurensin Gram_pos_anchor PF00746.21 AIF85031.1 - 0.41 10.6 3.0 1.4 8.9 0.1 2.4 2 0 0 2 2 2 0 LPXTG cell wall anchor motif ABC_tran PF00005.27 AIF85032.1 - 6.9e-32 110.8 0.0 1e-31 110.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIF85032.1 - 1e-07 32.1 0.1 0.0043 16.9 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIF85032.1 - 4.7e-05 22.9 0.3 0.021 14.2 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 AIF85032.1 - 7.4e-05 22.7 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase IstB_IS21 PF01695.17 AIF85032.1 - 0.0004 20.2 0.1 0.03 14.1 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA PF00004.29 AIF85032.1 - 0.00043 20.7 0.4 0.0059 17.0 0.4 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 AIF85032.1 - 0.0026 17.7 0.0 0.0053 16.7 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 AIF85032.1 - 0.0046 17.2 0.2 0.012 15.9 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AIF85032.1 - 0.0065 16.2 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIF85032.1 - 0.0076 16.6 0.0 0.01 16.2 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 AIF85032.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 AIF85032.1 - 0.011 16.2 0.1 0.018 15.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 AIF85032.1 - 0.012 15.8 0.0 0.026 14.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 AIF85032.1 - 0.014 15.4 0.0 0.052 13.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 AIF85032.1 - 0.019 14.7 0.0 0.099 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 AIF85032.1 - 0.024 15.2 0.0 0.039 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 AIF85032.1 - 0.036 12.9 0.0 0.11 11.3 0.0 1.6 2 0 0 2 2 2 0 Predicted ATPase of the ABC class RNA_helicase PF00910.22 AIF85032.1 - 0.036 14.4 0.0 0.12 12.7 0.0 1.9 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 AIF85032.1 - 0.037 14.0 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 AIF85032.1 - 0.04 13.7 0.0 0.081 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 AIF85032.1 - 0.057 13.0 0.0 0.097 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 AIF85032.1 - 0.067 12.6 0.0 0.098 12.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_33 PF13671.6 AIF85032.1 - 0.091 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 AIF85032.1 - 0.091 12.8 0.0 0.13 12.3 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase TsaE PF02367.17 AIF85032.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 AIF85032.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 AIF85032.1 - 0.15 11.4 0.1 1.1 8.6 0.0 2.3 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 AIF85032.1 - 0.16 11.0 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein MTHFR PF02219.17 AIF85033.1 - 0.00033 20.1 0.0 0.00059 19.3 0.0 1.5 1 1 0 1 1 1 1 Methylenetetrahydrofolate reductase Slp PF03843.13 AIF85033.1 - 0.085 12.2 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein Slp family zf-HIT PF04438.16 AIF85036.1 - 0.0057 16.5 6.7 0.017 15.0 2.6 2.2 2 0 0 2 2 2 1 HIT zinc finger DUF35_N PF12172.8 AIF85036.1 - 0.011 15.6 4.3 0.086 12.7 1.5 2.2 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc-ribbons_6 PF07191.12 AIF85036.1 - 0.011 15.7 5.7 0.1 12.6 1.3 2.1 1 1 1 2 2 2 0 zinc-ribbons DZR PF12773.7 AIF85036.1 - 0.029 14.4 6.6 0.14 12.2 6.6 2.0 1 1 0 1 1 1 0 Double zinc ribbon Ribosomal_L7Ae PF01248.26 AIF85036.1 - 0.044 13.5 0.3 0.048 13.4 0.3 1.2 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PolC_DP2 PF03833.13 AIF85036.1 - 0.09 10.6 2.9 0.082 10.8 2.9 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-Sec23_Sec24 PF04810.15 AIF85036.1 - 0.11 12.6 8.0 0.058 13.5 5.8 1.8 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger NRDD PF13597.6 AIF85036.1 - 0.43 9.3 5.4 0.39 9.4 5.4 1.1 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase MEDS PF14417.6 AIF85038.1 - 7.8e-09 35.6 0.3 2.6e-08 33.9 0.3 1.8 1 1 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Glyco_transf_54 PF04666.13 AIF85038.1 - 0.17 10.7 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region CopG_antitoxin PF12441.8 AIF85039.1 - 0.0085 16.6 0.1 0.063 13.8 0.0 2.4 2 2 2 4 4 4 1 CopG antitoxin of type II toxin-antitoxin system Sa_NUDIX PF18167.1 AIF85039.1 - 0.049 13.4 0.1 0.068 13.0 0.1 1.2 1 0 0 1 1 1 0 SMODS-associated NUDIX domain Usp PF00582.26 AIF85040.1 - 5.4e-32 111.2 0.1 6.9e-32 110.9 0.1 1.1 1 0 0 1 1 1 1 Universal stress protein family NUDIX PF00293.28 AIF85042.1 - 6.4e-10 39.2 0.0 7.8e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF1918 PF08940.11 AIF85046.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) GCD14 PF08704.10 AIF85048.1 - 1.2e-36 126.7 0.0 4.7e-34 118.2 0.0 2.1 1 1 1 2 2 2 2 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 AIF85048.1 - 1.6e-09 37.8 0.0 2.3e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 AIF85048.1 - 1.9e-08 34.3 0.0 2.8e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF85048.1 - 2.1e-06 27.2 0.0 3.2e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_3 PF01596.17 AIF85048.1 - 2e-05 23.9 0.0 3.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_25 PF13649.6 AIF85048.1 - 3.6e-05 24.4 0.0 9.3e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 AIF85048.1 - 0.0008 20.4 0.0 0.0015 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain GCD14_N PF14801.6 AIF85048.1 - 0.002 17.9 0.1 0.0038 17.0 0.1 1.5 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Fibrillarin PF01269.17 AIF85048.1 - 0.0028 16.8 0.0 0.0054 15.9 0.0 1.4 1 0 0 1 1 1 1 Fibrillarin Methyltransf_18 PF12847.7 AIF85048.1 - 0.0034 17.3 0.0 0.0053 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF85048.1 - 0.0035 17.9 0.0 0.0065 17.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF85048.1 - 0.0071 17.1 0.0 0.016 15.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 AIF85048.1 - 0.014 14.8 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 AIF85048.1 - 0.052 13.3 0.0 0.085 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) MTS PF05175.14 AIF85048.1 - 0.075 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain UPF0020 PF01170.18 AIF85048.1 - 0.089 12.5 0.0 0.24 11.0 0.0 1.7 1 1 1 2 2 2 0 Putative RNA methylase family UPF0020 DUF2171 PF09939.9 AIF85050.1 - 0.026 14.8 0.0 0.039 14.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2171) C1_2 PF03107.16 AIF85050.1 - 0.47 10.8 7.5 0.11 12.8 2.7 2.3 1 1 1 2 2 2 0 C1 domain DALR_1 PF05746.15 AIF85051.1 - 3.2e-30 104.7 1.6 3.2e-30 104.7 1.6 1.9 2 0 0 2 2 2 1 DALR anticodon binding domain tRNA-synt_1d PF00750.19 AIF85051.1 - 2.4e-27 95.8 2.7 1.4e-21 76.8 0.2 2.7 2 1 0 2 2 2 2 tRNA synthetases class I (R) Arg_tRNA_synt_N PF03485.16 AIF85051.1 - 3.9e-14 53.0 0.0 1.9e-13 50.8 0.0 2.2 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1g PF09334.11 AIF85051.1 - 0.028 13.2 0.9 0.053 12.3 0.1 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (M) Hydrolase_3 PF08282.12 AIF85052.1 - 1.4e-25 90.5 0.0 8.5e-18 65.0 0.1 2.0 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AIF85052.1 - 1.8e-07 31.7 2.5 9.2e-05 22.8 0.0 3.0 3 1 1 4 4 4 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AIF85052.1 - 1.6e-05 24.6 0.0 0.022 14.3 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.7 AIF85052.1 - 9.2e-05 22.9 0.1 0.0037 17.7 0.0 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AIF85052.1 - 0.0059 16.6 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 AIF85052.1 - 0.019 15.1 0.0 0.036 14.2 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pyrophosphatase PF00719.19 AIF85053.1 - 8.4e-58 194.7 1.4 9.6e-58 194.5 1.4 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase InPase PF18823.1 AIF85053.1 - 0.0071 16.1 0.3 0.076 12.7 0.0 2.3 2 1 0 2 2 2 1 Inorganic Pyrophosphatase DUF5622 PF18533.1 AIF85053.1 - 0.14 12.3 5.0 4.1 7.6 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5622) CHB_HEX_C_1 PF13290.6 AIF85054.1 - 2.6e-30 104.2 29.2 1.9e-16 59.8 4.8 4.0 4 0 0 4 4 4 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 AIF85054.1 - 6.9e-30 103.0 19.6 1.5e-16 60.2 3.6 3.6 3 0 0 3 3 3 2 Fn3 associated Polysacc_deac_1 PF01522.21 AIF85054.1 - 2.9e-10 40.1 0.0 5.9e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIF85054.1 - 1.6e-07 31.2 0.1 3.3e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) CHB_HEX_C PF03174.13 AIF85054.1 - 3.5e-06 26.9 5.7 0.0012 18.8 0.1 3.7 4 0 0 4 4 4 2 Chitobiase/beta-hexosaminidase C-terminal domain HYR PF02494.16 AIF85054.1 - 1.7e-05 25.1 19.1 0.0022 18.3 1.3 4.9 5 1 0 5 5 5 2 HYR domain Glyco_hydro_57 PF03065.15 AIF85054.1 - 0.0043 16.3 0.0 0.0068 15.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Y_Y_Y PF07495.13 AIF85054.1 - 0.0098 15.8 0.1 0.032 14.2 0.1 1.9 1 0 0 1 1 1 1 Y_Y_Y domain Transglut_C PF00927.22 AIF85054.1 - 0.041 14.0 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain PKD PF00801.20 AIF85054.1 - 2.7 7.9 10.3 0.27 11.1 0.5 4.1 4 0 0 4 4 4 0 PKD domain AAA PF00004.29 AIF85055.1 - 9.1e-37 126.4 0.0 3.9e-36 124.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.18 AIF85055.1 - 7.3e-07 29.2 3.5 1.3e-06 28.3 3.5 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 AIF85055.1 - 2.5e-06 27.2 0.0 6.5e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 AIF85055.1 - 4.3e-05 23.7 0.1 0.00013 22.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AIF85055.1 - 5.6e-05 23.6 0.0 0.0015 18.9 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AIF85055.1 - 0.00019 21.7 0.1 0.035 14.4 0.0 3.1 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 AIF85055.1 - 0.00026 20.8 0.0 0.00053 19.8 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Vps4_C PF09336.10 AIF85055.1 - 0.00051 20.0 0.1 0.0047 16.9 0.0 2.2 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RNA_helicase PF00910.22 AIF85055.1 - 0.00073 19.9 0.1 0.12 12.8 0.0 2.7 2 1 0 2 2 2 1 RNA helicase AAA_25 PF13481.6 AIF85055.1 - 0.0021 17.7 0.0 0.038 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 AIF85055.1 - 0.0024 17.9 0.0 0.038 14.0 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 AIF85055.1 - 0.0033 17.5 0.0 0.019 15.0 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 AIF85055.1 - 0.016 14.9 0.0 0.05 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 AIF85055.1 - 0.018 14.8 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 AIF85055.1 - 0.023 14.1 0.0 0.05 13.0 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 AIF85055.1 - 0.025 14.7 0.0 0.041 14.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 AIF85055.1 - 0.029 13.6 0.0 0.073 12.3 0.0 1.6 1 1 1 2 2 2 0 TIP49 P-loop domain AAA_18 PF13238.6 AIF85055.1 - 0.034 14.7 0.0 0.14 12.7 0.0 2.1 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 AIF85055.1 - 0.048 12.9 0.0 0.19 11.0 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin KAP_NTPase PF07693.14 AIF85055.1 - 0.07 12.3 0.0 0.9 8.7 0.0 2.0 1 1 1 2 2 2 0 KAP family P-loop domain ATPase PF06745.13 AIF85055.1 - 0.12 11.7 0.0 1.4 8.3 0.0 2.4 1 1 1 2 2 2 0 KaiC ABC_tran PF00005.27 AIF85055.1 - 0.14 12.7 0.1 1.2 9.6 0.0 2.2 2 0 0 2 2 2 0 ABC transporter ATPase_2 PF01637.18 AIF85055.1 - 0.14 12.0 0.1 1.9 8.3 0.0 2.4 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea PhoH PF02562.16 AIF85055.1 - 0.18 11.2 0.1 0.35 10.3 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein FliT PF05400.13 AIF85057.1 - 1.7 9.5 5.0 0.58 11.0 2.1 1.6 2 0 0 2 2 2 0 Flagellar protein FliT TrmB PF01978.19 AIF85058.1 - 6.7e-16 57.9 1.0 1.1e-15 57.2 0.3 1.7 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 AIF85058.1 - 0.021 14.0 0.0 0.043 13.0 0.0 1.5 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB MarR_2 PF12802.7 AIF85058.1 - 0.1 12.5 0.0 0.33 10.9 0.0 1.9 1 0 0 1 1 1 0 MarR family DUF192 PF02643.15 AIF85059.1 - 3e-28 97.8 0.0 4.3e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 tRNA-synt_1 PF00133.22 AIF85060.1 - 8.5e-132 440.4 0.1 1.2e-131 439.9 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AIF85060.1 - 1.3e-27 96.6 0.1 3.7e-27 95.1 0.0 1.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AIF85060.1 - 2e-21 76.2 0.9 2.4e-09 36.5 0.0 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 AIF85060.1 - 1.4e-05 24.6 0.0 0.00011 21.7 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 AIF85060.1 - 0.00049 19.1 0.0 0.0012 17.8 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (K) DZR PF12773.7 AIF85060.1 - 0.13 12.3 0.4 16 5.6 0.1 2.5 2 0 0 2 2 2 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 AIF85060.1 - 0.16 12.1 1.8 2.9 8.1 0.1 3.1 3 0 0 3 3 3 0 Zinc ribbon domain zf-ACC PF17848.1 AIF85060.1 - 0.29 11.2 3.2 17 5.6 0.1 3.0 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain MDD_C PF18376.1 AIF85061.1 - 0.026 14.3 0.0 0.06 13.1 0.0 1.5 2 0 0 2 2 2 0 Mevalonate 5-diphosphate decarboxylase C-terminal domain GPP34 PF05719.11 AIF85061.1 - 0.042 13.9 0.1 0.051 13.6 0.1 1.1 1 0 0 1 1 1 0 Golgi phosphoprotein 3 (GPP34) HrpJ PF07201.11 AIF85062.1 - 0.17 12.2 0.1 3.3 8.0 0.0 2.0 2 0 0 2 2 2 0 HrpJ-like domain Rieske PF00355.26 AIF85063.1 - 7.4e-18 64.3 0.0 9.8e-18 63.9 0.0 1.2 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIF85063.1 - 6.7e-09 35.6 0.0 9.5e-09 35.1 0.0 1.3 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain CBP_BcsG PF11658.8 AIF85063.1 - 0.11 10.9 0.0 0.13 10.6 0.0 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DSPc PF00782.20 AIF85065.1 - 8.3e-17 61.2 0.0 1.1e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AIF85065.1 - 8.1e-07 28.8 0.0 1.1e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 AIF85065.1 - 1.4e-06 28.5 0.0 2.1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 AIF85065.1 - 4.3e-06 26.9 0.0 6e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 AIF85065.1 - 0.0038 16.8 0.0 0.0081 15.7 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family DUF899 PF05988.12 AIF85066.1 - 5.1e-77 258.2 0.3 6.3e-77 257.9 0.3 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) AhpC-TSA PF00578.21 AIF85066.1 - 4.9e-05 23.2 0.0 7.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 3-dmu-9_3-mt PF06983.13 AIF85067.1 - 4.9e-05 23.8 0.0 4.9e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase TF_Zn_Ribbon PF08271.12 AIF85068.1 - 8.3e-05 22.0 1.0 0.00011 21.6 1.0 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding DNA_RNApol_7kD PF03604.13 AIF85068.1 - 0.0035 17.0 1.3 0.0059 16.3 1.3 1.4 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit zf-ribbon_3 PF13248.6 AIF85068.1 - 0.0042 16.5 4.6 0.038 13.4 4.7 2.0 1 1 0 1 1 1 1 zinc-ribbon domain Prok-RING_1 PF14446.6 AIF85068.1 - 0.005 16.7 0.9 0.0066 16.3 0.9 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 Lar_restr_allev PF14354.6 AIF85068.1 - 0.0063 16.9 2.5 0.048 14.0 2.3 2.1 1 1 1 2 2 2 2 Restriction alleviation protein Lar zinc_ribbon_4 PF13717.6 AIF85068.1 - 0.0091 15.9 2.3 0.058 13.3 2.3 2.0 1 1 0 1 1 1 1 zinc-ribbon domain HypA PF01155.19 AIF85068.1 - 0.0092 16.0 0.3 0.01 15.9 0.3 1.2 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CpXC PF14353.6 AIF85068.1 - 0.018 15.1 1.8 0.68 10.0 0.2 2.1 1 1 1 2 2 2 0 CpXC protein DZR PF12773.7 AIF85068.1 - 0.018 15.0 1.2 0.032 14.3 1.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon Ribosomal_S27e PF01667.17 AIF85068.1 - 0.019 14.7 0.4 0.025 14.3 0.4 1.2 1 0 0 1 1 1 0 Ribosomal protein S27 OrfB_Zn_ribbon PF07282.11 AIF85068.1 - 0.022 14.7 2.1 0.028 14.3 1.7 1.3 1 1 0 1 1 1 0 Putative transposase DNA-binding domain Zn_Tnp_IS1595 PF12760.7 AIF85068.1 - 0.04 13.9 0.4 2.5 8.1 0.1 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DNA_ligase_ZBD PF03119.16 AIF85068.1 - 0.043 13.8 0.4 0.072 13.1 0.4 1.4 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain RNA_POL_M_15KD PF02150.16 AIF85068.1 - 0.061 13.2 1.0 0.12 12.2 1.0 1.5 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit YyzF PF14116.6 AIF85068.1 - 0.062 13.3 3.9 0.13 12.3 0.3 2.2 1 1 1 2 2 2 0 YyzF-like protein zf-H2C2_2 PF13465.6 AIF85068.1 - 0.063 13.7 3.8 5.2 7.7 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zinc_ribbon_2 PF13240.6 AIF85068.1 - 0.075 12.8 4.8 0.22 11.3 4.8 1.8 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_13 PF09855.9 AIF85068.1 - 0.075 13.2 5.0 0.98 9.6 0.4 2.2 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) IBR PF01485.21 AIF85068.1 - 0.1 12.9 1.6 0.14 12.4 1.5 1.3 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain DUF2225 PF09986.9 AIF85068.1 - 0.11 12.2 0.8 0.23 11.1 0.0 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) UPF0547 PF10571.9 AIF85068.1 - 0.24 11.5 3.9 2.9 8.1 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-ISL3 PF14690.6 AIF85068.1 - 0.25 12.0 2.9 0.61 10.8 0.7 2.0 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-HIT PF04438.16 AIF85068.1 - 0.91 9.5 5.8 11 6.0 0.2 2.1 2 0 0 2 2 2 0 HIT zinc finger Zn-ribbon_8 PF09723.10 AIF85068.1 - 1.4 9.1 5.9 1.7 8.8 0.9 2.1 1 1 0 2 2 2 0 Zinc ribbon domain Ribosomal_S6e PF01092.19 AIF85069.1 - 2.6e-23 82.4 0.3 3.8e-23 81.8 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S6e GTP_EFTU PF00009.27 AIF85070.1 - 2.6e-30 105.4 0.3 1.8e-29 102.7 0.3 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.11 AIF85070.1 - 1.3e-28 99.1 0.1 3.2e-28 97.8 0.1 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.25 AIF85070.1 - 6.2e-05 23.3 0.9 0.00015 22.1 0.9 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 AIF85070.1 - 0.00016 21.6 0.7 0.003 17.5 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 AIF85070.1 - 0.003 17.6 0.0 0.0057 16.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 AIF85070.1 - 0.0054 16.7 0.1 0.012 15.7 0.1 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain PIN_9 PF18477.1 AIF85071.1 - 9.6e-22 77.5 1.2 1.1e-21 77.3 1.2 1.0 1 0 0 1 1 1 1 PIN like domain DUF5615 PF18480.1 AIF85071.1 - 0.023 14.5 0.1 0.046 13.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) PIN_4 PF13638.6 AIF85071.1 - 0.027 14.8 0.2 0.079 13.2 0.2 1.8 1 1 0 1 1 1 0 PIN domain PIN PF01850.21 AIF85071.1 - 0.047 14.2 0.2 0.13 12.8 0.2 1.7 1 1 0 1 1 1 0 PIN domain Lactamase_B_3 PF13483.6 AIF85072.1 - 8.4e-32 110.3 1.0 1e-31 110.0 1.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 AIF85072.1 - 9.3e-19 67.7 0.3 1.2e-18 67.4 0.3 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain ATP-synt_F PF01990.17 AIF85072.1 - 0.041 14.2 0.1 1.2 9.5 0.0 2.3 2 0 0 2 2 2 0 ATP synthase (F/14-kDa) subunit Lactamase_B PF00753.27 AIF85072.1 - 0.054 13.5 2.2 0.17 11.9 2.3 1.9 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Pro_isomerase PF00160.21 AIF85073.1 - 7e-49 166.1 0.0 1.2e-48 165.4 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD STT3 PF02516.14 AIF85073.1 - 1.2e-38 133.3 26.1 1.9e-38 132.7 26.1 1.3 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.6 AIF85073.1 - 3.6e-06 27.3 15.7 3.6e-06 27.3 15.7 3.3 3 2 2 5 5 5 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Inositol_P PF00459.25 AIF85074.1 - 2.2e-46 158.5 0.0 2.5e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.20 AIF85074.1 - 0.027 13.9 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase, N-terminal domain SnoaL_2 PF12680.7 AIF85075.1 - 1e-08 35.7 0.0 1.3e-08 35.4 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIF85075.1 - 3.4e-05 24.2 0.0 3.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 AIF85075.1 - 0.0006 20.1 0.1 0.0013 19.0 0.1 1.5 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 AIF85075.1 - 0.04 14.0 0.0 0.051 13.7 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like domain DS PF01916.17 AIF85076.1 - 1.7e-93 313.0 0.0 2e-93 312.8 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase DS PF01916.17 AIF85078.1 - 8.9e-77 258.2 0.0 1.1e-76 257.9 0.0 1.1 1 0 0 1 1 1 1 Deoxyhypusine synthase LigT_PEase PF02834.16 AIF85080.1 - 3.9e-22 78.2 0.0 1.4e-13 50.8 0.0 2.2 2 0 0 2 2 2 2 LigT like Phosphoesterase 2_5_RNA_ligase2 PF13563.6 AIF85080.1 - 8.4e-11 42.0 0.0 1e-10 41.8 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily AKAP7_NLS PF10469.9 AIF85080.1 - 8.4e-08 32.4 0.0 1.2e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain DUF2680 PF10925.8 AIF85080.1 - 0.13 12.3 0.8 12 6.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2680) tRNA_NucTransf2 PF09249.11 AIF85081.1 - 9.3e-37 125.7 0.0 2e-36 124.7 0.0 1.6 1 0 0 1 1 1 1 tRNA nucleotidyltransferase, second domain NTP_transf_2 PF01909.23 AIF85081.1 - 1.6e-11 44.4 0.0 3e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain SMODS PF18144.1 AIF85081.1 - 8.7e-07 29.3 0.0 2.3e-06 27.9 0.0 1.6 2 0 0 2 2 2 1 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain Polbeta PF18765.1 AIF85081.1 - 0.036 14.1 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Pkinase PF00069.25 AIF85082.1 - 0.011 15.1 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain APH PF01636.23 AIF85082.1 - 0.011 15.6 0.2 0.19 11.6 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 AIF85082.1 - 0.013 15.1 0.1 0.4 10.2 0.0 2.1 1 1 1 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.22 AIF85082.1 - 0.018 14.7 0.0 0.031 13.9 0.0 1.4 1 1 0 1 1 1 0 RIO1 family PAC2 PF09754.9 AIF85083.1 - 2.6e-28 99.5 0.0 2.9e-28 99.3 0.0 1.0 1 0 0 1 1 1 1 PAC2 family HhH-GPD PF00730.25 AIF85084.1 - 1.7e-16 60.6 0.0 2.2e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 AIF85084.1 - 0.14 12.1 0.0 0.41 10.6 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF5601 PF18151.1 AIF85085.1 - 0.03 14.6 0.0 0.058 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) GGA_N-GAT PF18308.1 AIF85085.1 - 0.043 13.4 0.1 0.081 12.6 0.1 1.4 1 0 0 1 1 1 0 GGA N-GAT domain Ribosomal_L2_C PF03947.18 AIF85086.1 - 1.3e-37 128.8 2.0 2.4e-37 127.9 1.8 1.6 1 1 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 AIF85086.1 - 1.8e-11 43.9 0.1 4.8e-11 42.5 0.1 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Glyoxalase PF00903.25 AIF85087.1 - 1.1e-07 32.1 0.0 1.9e-07 31.3 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AIF85087.1 - 7.4e-05 23.5 0.0 0.00015 22.5 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain NIR_SIR PF01077.22 AIF85088.1 - 5.3e-44 149.5 0.1 1.9e-32 112.0 0.0 2.8 3 0 0 3 3 3 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 AIF85088.1 - 1.6e-33 114.4 0.1 9.1e-19 67.1 0.0 2.5 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Rhodanese PF00581.20 AIF85089.1 - 8.3e-33 113.1 0.0 2.8e-15 56.7 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain OrfB_Zn_ribbon PF07282.11 AIF85090.1 - 4.8e-21 74.5 0.1 1e-20 73.4 0.1 1.6 1 0 0 1 1 1 1 Putative transposase DNA-binding domain OrfB_IS605 PF01385.19 AIF85090.1 - 3.4e-19 69.2 0.6 7.4e-19 68.1 0.6 1.5 1 0 0 1 1 1 1 Probable transposase HTH_OrfB_IS605 PF12323.8 AIF85090.1 - 3.6e-10 39.2 0.4 1.1e-09 37.6 0.4 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain Zn_ribbon_SprT PF17283.2 AIF85090.1 - 0.0091 15.9 2.2 0.022 14.6 2.2 1.7 1 0 0 1 1 1 1 SprT-like zinc ribbon domain RRXRR PF14239.6 AIF85090.1 - 0.024 14.5 1.0 0.049 13.5 1.0 1.5 1 0 0 1 1 1 0 RRXRR protein DZR PF12773.7 AIF85090.1 - 0.031 14.3 0.6 0.064 13.3 0.6 1.4 1 0 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 AIF85090.1 - 0.055 13.4 0.8 0.12 12.4 0.8 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF1451 PF07295.11 AIF85090.1 - 0.086 12.9 2.7 0.075 13.1 0.6 1.9 2 1 0 2 2 2 0 Zinc-ribbon containing domain TMF_DNA_bd PF12329.8 AIF85091.1 - 0.0081 16.1 1.5 0.028 14.4 1.5 1.9 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding AAA_17 PF13207.6 AIF85092.1 - 3.6e-16 59.8 0.3 6.1e-16 59.1 0.3 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AIF85092.1 - 6.6e-15 55.8 0.1 1e-14 55.2 0.1 1.3 1 0 0 1 1 1 1 AAA domain ADK PF00406.22 AIF85092.1 - 2.4e-06 27.7 0.2 2.7e-06 27.5 0.2 1.3 1 0 0 1 1 1 1 Adenylate kinase CoaE PF01121.20 AIF85092.1 - 0.0001 22.0 0.2 0.00033 20.4 0.1 1.8 1 1 1 2 2 2 1 Dephospho-CoA kinase AAA_33 PF13671.6 AIF85092.1 - 0.00012 22.2 0.3 0.00061 20.0 0.3 2.0 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 AIF85092.1 - 0.00015 22.1 0.0 0.00024 21.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 AIF85092.1 - 0.00028 20.2 0.1 0.0024 17.2 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin APS_kinase PF01583.20 AIF85092.1 - 0.00059 19.8 0.1 0.0031 17.4 0.0 2.0 2 0 0 2 2 2 1 Adenylylsulphate kinase ABC_tran PF00005.27 AIF85092.1 - 0.0023 18.5 0.3 0.0076 16.8 0.3 1.8 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 AIF85092.1 - 0.0028 17.9 0.2 0.0045 17.3 0.2 1.5 1 1 0 1 1 1 1 AAA domain PGM_PMM_II PF02879.16 AIF85092.1 - 0.0083 16.7 0.0 0.03 15.0 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II MeaB PF03308.16 AIF85092.1 - 0.01 14.8 0.0 0.017 14.1 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Torsin PF06309.11 AIF85092.1 - 0.011 15.8 0.0 0.055 13.6 0.0 1.9 1 1 1 2 2 2 0 Torsin AAA_16 PF13191.6 AIF85092.1 - 0.016 15.6 1.0 0.038 14.4 1.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 AIF85092.1 - 0.019 14.2 0.0 0.024 13.8 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain KTI12 PF08433.10 AIF85092.1 - 0.024 14.1 0.0 0.042 13.3 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 NTPase_1 PF03266.15 AIF85092.1 - 0.03 14.2 0.2 0.074 13.0 0.2 1.8 1 1 0 1 1 1 0 NTPase Ploopntkinase3 PF18751.1 AIF85092.1 - 0.047 13.6 0.1 0.083 12.8 0.1 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_14 PF13173.6 AIF85092.1 - 0.056 13.5 0.0 0.14 12.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 AIF85092.1 - 0.056 13.1 0.1 0.18 11.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 AIF85092.1 - 0.061 13.4 0.0 0.11 12.6 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 AIF85092.1 - 0.07 13.1 0.1 0.13 12.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) UPF0180 PF03698.13 AIF85092.1 - 0.07 13.3 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) Rad17 PF03215.15 AIF85092.1 - 0.095 12.6 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain RNA_binding PF01877.17 AIF85093.1 - 6.1e-09 36.2 0.0 1.9e-08 34.6 0.0 1.7 1 1 0 1 1 1 1 RNA binding zf-ribbon_3 PF13248.6 AIF85094.1 - 0.0013 18.1 3.0 0.096 12.1 0.4 2.2 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_2 PF13240.6 AIF85094.1 - 0.01 15.5 2.9 0.087 12.6 0.4 2.2 2 0 0 2 2 2 0 zinc-ribbon domain GFA PF04828.14 AIF85094.1 - 0.012 15.9 2.0 0.026 14.8 2.0 1.6 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_15 PF17032.5 AIF85094.1 - 0.013 16.2 2.0 0.015 16.1 2.0 1.0 1 0 0 1 1 1 0 zinc-ribbon family HypA PF01155.19 AIF85094.1 - 0.019 14.9 0.7 0.02 14.9 0.7 1.0 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-NADH-PPase PF09297.11 AIF85094.1 - 0.024 14.3 0.2 0.024 14.3 0.2 1.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DZR PF12773.7 AIF85094.1 - 0.05 13.6 3.3 0.095 12.7 3.3 1.5 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 AIF85094.1 - 0.17 11.8 8.4 1.2 9.2 8.4 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zf-RanBP PF00641.18 AIF85094.1 - 0.77 9.1 5.7 4.2 6.8 0.6 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others DUF1451 PF07295.11 AIF85094.1 - 1.1 9.3 3.2 3.9 7.5 3.2 1.7 1 1 0 1 1 1 0 Zinc-ribbon containing domain ADK_lid PF05191.14 AIF85094.1 - 1.1 9.2 6.9 3.9 7.5 6.9 1.9 1 1 0 1 1 1 0 Adenylate kinase, active site lid zf-CCHC_5 PF14787.6 AIF85094.1 - 4.3 7.1 7.4 1.5 8.6 0.3 2.5 2 1 0 2 2 2 0 GAG-polyprotein viral zinc-finger ABC_tran PF00005.27 AIF85095.1 - 1.4e-32 113.0 0.0 2.4e-32 112.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIF85095.1 - 2.6e-08 34.1 1.3 1.1e-05 25.5 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 AIF85095.1 - 2.3e-06 28.2 0.1 1.9e-05 25.3 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) AAA_15 PF13175.6 AIF85095.1 - 3.6e-06 27.0 0.0 0.073 12.8 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 AIF85095.1 - 0.0011 19.3 0.1 0.0045 17.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 AIF85095.1 - 0.0012 18.5 0.2 0.0024 17.6 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SRP54 PF00448.22 AIF85095.1 - 0.0012 18.5 0.3 0.0026 17.4 0.1 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA PF00004.29 AIF85095.1 - 0.0015 19.0 0.1 0.034 14.6 0.1 2.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 AIF85095.1 - 0.0031 18.1 0.0 0.0051 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AIF85095.1 - 0.074 12.8 0.6 3.6 7.3 0.0 2.7 2 1 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 AIF85095.1 - 0.075 13.3 0.0 0.19 12.0 0.0 1.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.12 AIF85095.1 - 0.096 12.0 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 AIF85095.1 - 0.1 12.3 0.0 1 9.0 0.0 2.2 2 1 0 2 2 2 0 AAA domain ABC2_membrane PF01061.24 AIF85096.1 - 5.8e-37 127.1 22.7 6.9e-37 126.9 22.7 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 AIF85096.1 - 5.2e-15 55.4 26.4 5.2e-15 55.4 26.4 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 AIF85096.1 - 1.2e-06 28.0 17.0 1.2e-06 28.0 17.0 2.0 2 0 0 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 AIF85096.1 - 0.052 13.5 15.2 0.24 11.3 15.2 1.9 1 1 0 1 1 1 0 ABC-2 family transporter protein MscL PF01741.18 AIF85096.1 - 5.7 7.3 7.4 1.6 9.0 2.3 2.1 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL Abhydrolase_1 PF00561.20 AIF85097.1 - 3.7e-14 53.0 0.0 5.6e-12 45.8 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIF85097.1 - 1.4e-11 45.4 0.0 1.7e-11 45.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AIF85097.1 - 8.5e-05 21.9 0.0 0.00071 18.9 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 AIF85097.1 - 0.0023 17.6 0.0 0.0087 15.7 0.0 1.8 2 0 0 2 2 2 1 Putative esterase Ndr PF03096.14 AIF85097.1 - 0.0033 16.2 0.0 0.22 10.2 0.0 2.1 2 0 0 2 2 2 2 Ndr family Thioesterase PF00975.20 AIF85097.1 - 0.0038 17.4 0.0 0.0051 17.0 0.0 1.5 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_8 PF06259.12 AIF85097.1 - 0.0052 16.4 0.0 0.0099 15.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase PGAP1 PF07819.13 AIF85097.1 - 0.0079 15.9 0.0 0.26 11.0 0.0 2.2 1 1 0 1 1 1 1 PGAP1-like protein PAF-AH_p_II PF03403.13 AIF85097.1 - 0.051 12.1 0.0 0.078 11.5 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II RNR_N PF08343.10 AIF85097.1 - 0.097 12.7 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 Ribonucleotide reductase N-terminal Peptidase_S9 PF00326.21 AIF85097.1 - 0.17 11.4 0.0 1.4 8.4 0.0 2.1 1 1 1 2 2 2 0 Prolyl oligopeptidase family FeoC PF09012.10 AIF85100.1 - 0.038 14.0 0.0 0.049 13.7 0.0 1.1 1 0 0 1 1 1 0 FeoC like transcriptional regulator MarR_2 PF12802.7 AIF85100.1 - 0.095 12.6 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 MarR family ABM PF03992.16 AIF85102.1 - 0.021 14.9 0.1 0.081 13.1 0.1 1.9 1 1 1 2 2 2 0 Antibiotic biosynthesis monooxygenase BNR PF02012.20 AIF85103.1 - 0.24 11.5 9.1 0.3 11.3 1.1 3.5 3 0 0 3 3 3 0 BNR/Asp-box repeat Polysacc_deac_1 PF01522.21 AIF85104.1 - 1.2e-11 44.6 0.0 5.1e-11 42.6 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIF85104.1 - 2.8e-08 33.7 0.0 4.7e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Big_7 PF17957.1 AIF85104.1 - 3.7e-05 24.4 2.3 3.7e-05 24.4 2.3 3.0 3 1 0 3 3 3 1 Bacterial Ig domain HECW1_helix PF18436.1 AIF85104.1 - 0.007 16.4 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Helical box domain of E3 ubiquitin-protein ligase HECW1 DRE2_N PF16803.5 AIF85104.1 - 0.015 15.5 0.2 0.044 14.0 0.2 1.7 1 1 0 1 1 1 0 Fe-S cluster assembly protein DRE2 N-terminus Rieske_3 PF18465.1 AIF85104.1 - 0.098 12.9 0.0 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 Rieske 3Fe-4S TerC PF03741.16 AIF85105.1 - 1.7e-49 167.9 15.7 1.7e-49 167.9 15.7 1.4 2 0 0 2 2 2 1 Integral membrane protein TerC family DUF5592 PF17332.2 AIF85105.1 - 0.061 13.9 0.4 0.061 13.9 0.4 3.1 3 1 0 3 3 3 0 Family of unknown function (DUF5592) DUF3397 PF11877.8 AIF85105.1 - 0.52 10.5 17.5 0.041 14.1 3.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3397) PHO4 PF01384.20 AIF85105.1 - 6.6 5.7 13.7 0.15 11.1 4.0 2.2 1 1 1 2 2 2 0 Phosphate transporter family zf-Di19 PF05605.12 AIF85106.1 - 5.8e-05 23.3 0.1 7e-05 23.1 0.1 1.1 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 AIF85106.1 - 0.00032 21.3 0.6 0.00042 20.9 0.6 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 AIF85106.1 - 0.0012 19.2 0.1 0.0012 19.2 0.1 1.0 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 AIF85106.1 - 0.0072 16.2 0.2 0.0098 15.7 0.2 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 AIF85106.1 - 0.011 16.1 1.3 0.014 15.8 1.3 1.2 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF629 PF04780.12 AIF85106.1 - 0.072 11.6 0.0 0.072 11.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) Actin_micro PF17003.5 AIF85106.1 - 0.14 11.4 0.1 0.15 11.2 0.1 1.0 1 0 0 1 1 1 0 Putative actin-like family zf-H2C2_5 PF13909.6 AIF85106.1 - 0.4 10.5 4.2 0.86 9.4 4.2 1.5 1 1 0 1 1 1 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 AIF85106.1 - 0.44 11.1 3.4 2.5 8.7 0.2 2.1 2 0 0 2 2 2 0 Zinc-finger double domain CopG_antitoxin PF12441.8 AIF85107.1 - 0.0016 19.0 0.1 0.028 14.9 0.0 2.4 2 0 0 2 2 2 1 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIF85107.1 - 0.0021 17.8 0.0 0.0046 16.8 0.0 1.5 1 0 0 1 1 1 1 HicB family DUF2555 PF10742.9 AIF85107.1 - 0.047 13.5 0.0 0.099 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) RE_BstXI PF09552.10 AIF85107.1 - 0.052 12.7 0.0 0.085 12.0 0.0 1.3 1 0 0 1 1 1 0 BstXI restriction endonuclease MarR_2 PF12802.7 AIF85108.1 - 0.0042 16.9 0.1 0.0078 16.1 0.1 1.4 1 0 0 1 1 1 1 MarR family SSF PF00474.17 AIF85108.1 - 0.18 10.6 3.0 0.26 10.1 3.0 1.1 1 0 0 1 1 1 0 Sodium:solute symporter family MgtC PF02308.16 AIF85109.1 - 1.3e-31 109.4 7.3 1.6e-31 109.2 7.3 1.0 1 0 0 1 1 1 1 MgtC family DUF308 PF03729.13 AIF85111.1 - 2.1e-09 37.6 49.1 2.9e-05 24.3 19.1 3.2 2 1 1 3 3 3 3 Short repeat of unknown function (DUF308) DUF2892 PF11127.8 AIF85111.1 - 4.1 7.5 41.0 7.7 6.6 11.7 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF2892) SurA_N_2 PF13623.6 AIF85113.1 - 0.079 12.8 0.8 0.22 11.4 0.3 2.1 1 1 1 2 2 2 0 SurA N-terminal domain SnoaL PF07366.12 AIF85115.1 - 6.5e-08 32.4 0.0 7e-08 32.3 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase Collagen PF01391.18 AIF85118.1 - 0.067 13.0 1.2 0.067 13.0 1.2 1.9 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) LAP1C PF05609.12 AIF85119.1 - 0.78 8.8 15.7 1.1 8.3 15.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CopG_antitoxin PF12441.8 AIF85121.1 - 0.0029 18.1 0.1 0.013 16.0 0.0 2.1 2 1 0 2 2 2 1 CopG antitoxin of type II toxin-antitoxin system Kin17_mid PF10357.9 AIF85121.1 - 0.024 14.6 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein PSD2 PF07624.11 AIF85121.1 - 0.044 13.6 0.2 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) GP24_25 PF17388.2 AIF85123.1 - 0.061 13.3 0.1 0.069 13.1 0.1 1.2 1 0 0 1 1 1 0 Tail assembly gene products 24 & 25 FMN_red PF03358.15 AIF85125.1 - 1.4e-42 145.0 0.0 1.8e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 AIF85125.1 - 1.9e-08 34.3 0.0 2.9e-08 33.7 0.0 1.5 1 1 0 1 1 1 1 Flavodoxin-like fold DUF608 PF04685.13 AIF85126.1 - 2.5e-06 26.9 0.1 3.9e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region GDE_C PF06202.14 AIF85126.1 - 0.0031 16.5 0.1 0.98 8.3 0.1 2.3 2 0 0 2 2 2 2 Amylo-alpha-1,6-glucosidase Trehalase PF01204.18 AIF85126.1 - 0.048 12.5 0.0 0.066 12.0 0.0 1.2 1 0 0 1 1 1 0 Trehalase Dodecin PF07311.12 AIF85127.1 - 2.6e-24 85.3 0.9 2.8e-24 85.1 0.9 1.0 1 0 0 1 1 1 1 Dodecin Glycos_transf_1 PF00534.20 AIF85128.1 - 4.6e-23 81.6 0.0 8.9e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AIF85128.1 - 6.7e-11 42.8 0.0 1.8e-10 41.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 AIF85128.1 - 0.0003 21.1 0.0 0.00071 19.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 ALG11_N PF15924.5 AIF85128.1 - 0.0009 19.3 0.1 0.0066 16.5 0.1 2.0 2 0 0 2 2 2 1 ALG11 mannosyltransferase N-terminus PBP_like_2 PF12849.7 AIF85129.1 - 1.7e-22 80.5 4.5 2.4e-22 79.9 4.5 1.2 1 0 0 1 1 1 1 PBP superfamily domain PG_isomerase_N PF18353.1 AIF85129.1 - 0.031 14.7 0.1 0.092 13.1 0.1 1.8 1 0 0 1 1 1 0 Phosphoglucose isomerase N-terminal domain Sigma_reg_N PF13800.6 AIF85129.1 - 0.099 12.9 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Glyco_trans_2_3 PF13632.6 AIF85131.1 - 1.4e-10 41.4 0.0 2.5e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Fringe PF02434.16 AIF85131.1 - 5.8e-05 22.6 0.0 8.5e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Fringe-like Glyco_tranf_2_3 PF13641.6 AIF85131.1 - 6e-05 23.0 0.0 0.00013 21.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 MeaB PF03308.16 AIF85131.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DNA_alkylation PF08713.11 AIF85133.1 - 2.9e-65 220.0 0.2 3.3e-65 219.8 0.2 1.0 1 0 0 1 1 1 1 DNA alkylation repair enzyme DUF167 PF02594.16 AIF85134.1 - 2.2e-16 59.7 0.1 2.4e-16 59.6 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 Mrr_N PF14338.6 AIF85134.1 - 0.023 14.8 0.0 0.029 14.5 0.0 1.2 1 0 0 1 1 1 0 Mrr N-terminal domain Tautomerase_2 PF14552.6 AIF85134.1 - 0.029 14.5 0.1 0.09 12.9 0.1 1.7 1 1 1 2 2 2 0 Tautomerase enzyme HTH_42 PF06224.12 AIF85134.1 - 0.054 13.0 0.0 0.054 13.0 0.0 1.0 1 0 0 1 1 1 0 Winged helix DNA-binding domain CAP PF00188.26 AIF85135.1 - 8.2e-08 33.1 0.0 1.9e-07 31.9 0.0 1.6 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Ipi1_N PF12333.8 AIF85136.1 - 0.14 12.7 0.0 0.17 12.5 0.0 1.1 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation Peptidase_M3 PF01432.20 AIF85137.1 - 9.1e-46 157.1 0.0 1.3e-45 156.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M3_N PF08439.10 AIF85137.1 - 1.5e-07 31.5 0.3 5.2e-06 26.6 0.1 3.3 4 0 0 4 4 4 1 Oligopeptidase F Peptidase_M78 PF06114.13 AIF85137.1 - 0.07 13.1 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 IrrE N-terminal-like domain B56 PF01603.20 AIF85137.1 - 0.1 11.5 0.1 0.15 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein phosphatase 2A regulatory B subunit (B56 family) SBF PF01758.16 AIF85138.1 - 7.5e-13 48.6 15.2 7.5e-13 48.6 15.2 1.6 2 0 0 2 2 2 1 Sodium Bile acid symporter family TMEM208_SND2 PF05620.11 AIF85138.1 - 3.9 7.2 7.2 19 5.0 0.3 3.2 1 1 2 3 3 3 0 SRP-independent targeting protein 2/TMEM208 HpcH_HpaI PF03328.14 AIF85139.1 - 1.7e-49 167.9 2.4 2.2e-49 167.6 2.4 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 AIF85139.1 - 6.4e-17 61.7 0.2 6.9e-08 32.0 0.1 2.1 1 1 1 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold ADH_zinc_N PF00107.26 AIF85140.1 - 5.4e-28 97.6 0.2 9e-28 96.8 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AIF85140.1 - 1.2e-26 92.8 0.0 2.5e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 AIF85140.1 - 2.9e-17 63.9 0.0 6.4e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_16 PF10294.9 AIF85140.1 - 0.069 12.9 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Lysine methyltransferase dsDNA_bind PF01984.20 AIF85141.1 - 5.3e-25 87.9 0.9 5.8e-25 87.7 0.9 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Tom5 PF10642.9 AIF85141.1 - 0.025 14.6 0.4 0.055 13.5 0.4 1.7 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase Ribosomal_S19e PF01090.19 AIF85142.1 - 1.8e-54 183.1 0.1 2.1e-54 182.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Rpr2 PF04032.16 AIF85143.1 - 1.3e-12 47.8 0.3 1.6e-12 47.6 0.3 1.1 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zinc_ribbon_4 PF13717.6 AIF85143.1 - 0.011 15.7 2.0 0.46 10.4 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain PapD-like PF14874.6 AIF85143.1 - 0.015 15.4 0.1 0.017 15.2 0.1 1.2 1 0 0 1 1 1 0 Flagellar-associated PapD-like DUF4636 PF15468.6 AIF85143.1 - 0.044 13.5 0.3 0.048 13.4 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) DUF572 PF04502.13 AIF85143.1 - 0.073 12.7 0.7 0.082 12.5 0.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) ADK_lid PF05191.14 AIF85143.1 - 0.71 9.9 3.8 1.4 9.0 0.9 2.2 2 0 0 2 2 2 0 Adenylate kinase, active site lid EMG1 PF03587.14 AIF85144.1 - 9.7e-41 139.6 0.0 1.1e-40 139.3 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase UbiA PF01040.18 AIF85145.1 - 3.3e-51 174.0 21.6 4.1e-51 173.7 21.6 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Abhydrolase_2 PF02230.16 AIF85145.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase AsnC_trans_reg PF01037.21 AIF85146.1 - 9.5e-15 54.3 0.1 1.6e-14 53.6 0.1 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 AIF85146.1 - 2.1e-13 49.6 0.7 4.1e-13 48.7 0.7 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF85146.1 - 2.4e-09 36.9 0.0 5.1e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain MarR PF01047.22 AIF85146.1 - 2.5e-06 27.3 0.0 5.7e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIF85146.1 - 2.1e-05 24.3 0.7 4.2e-05 23.4 0.1 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 AIF85146.1 - 0.00033 20.7 1.0 0.00047 20.3 0.9 1.5 1 1 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_11 PF08279.12 AIF85146.1 - 0.00049 20.0 0.4 0.0011 18.9 0.4 1.5 1 0 0 1 1 1 1 HTH domain Ribosomal_S25 PF03297.15 AIF85146.1 - 0.0022 18.2 2.7 0.0031 17.7 0.9 1.9 2 0 0 2 2 2 1 S25 ribosomal protein HTH_5 PF01022.20 AIF85146.1 - 0.0063 16.4 0.3 0.013 15.4 0.3 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family Rrf2 PF02082.20 AIF85146.1 - 0.0065 16.8 0.1 0.014 15.7 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulator HTH_20 PF12840.7 AIF85146.1 - 0.0066 16.5 0.0 0.024 14.7 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 AIF85146.1 - 0.017 15.0 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 MarR family Mga PF05043.13 AIF85146.1 - 0.036 14.6 0.4 0.074 13.6 0.1 1.6 2 0 0 2 2 2 0 Mga helix-turn-helix domain HTH_34 PF13601.6 AIF85146.1 - 0.048 13.8 0.1 0.092 12.9 0.1 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain Fe_dep_repress PF01325.19 AIF85146.1 - 0.096 12.9 0.2 0.23 11.7 0.2 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Semialdhyde_dhC PF02774.18 AIF85147.1 - 6.1e-38 130.7 0.0 9.2e-38 130.1 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 AIF85147.1 - 2.4e-26 92.5 0.0 4.6e-26 91.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Gp_dh_C PF02800.20 AIF85147.1 - 0.00014 21.5 0.1 0.053 13.1 0.0 2.5 2 0 0 2 2 2 2 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain DapB_N PF01113.20 AIF85147.1 - 0.0016 18.5 0.0 0.0037 17.4 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Ldh_1_N PF00056.23 AIF85147.1 - 0.088 12.9 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Aminotran_1_2 PF00155.21 AIF85148.1 - 2.5e-44 151.9 0.0 3.3e-44 151.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II CbiA PF01656.23 AIF85149.1 - 7.7e-21 74.5 0.0 1e-20 74.1 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 AIF85149.1 - 8.2e-19 68.2 0.1 6.3e-18 65.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AIF85149.1 - 0.0079 15.9 0.1 0.012 15.3 0.1 1.5 1 1 0 1 1 1 1 AAA domain MobB PF03205.14 AIF85149.1 - 0.0098 15.8 0.0 0.1 12.5 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.27 AIF85149.1 - 0.051 14.1 0.0 0.074 13.6 0.0 1.3 1 0 0 1 1 1 0 ABC transporter cobW PF02492.19 AIF85149.1 - 0.08 12.5 0.0 2 7.9 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CobD_Cbib PF03186.13 AIF85150.1 - 5.1e-87 291.6 3.9 6.5e-87 291.3 3.9 1.1 1 0 0 1 1 1 1 CobD/Cbib protein CobS PF02654.15 AIF85151.1 - 4e-41 141.5 18.5 4.6e-41 141.3 18.5 1.0 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase NTP_transf_3 PF12804.7 AIF85152.1 - 3.8e-10 40.4 0.3 4.2e-10 40.2 0.3 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Ribosomal_S27e PF01667.17 AIF85153.1 - 6.4e-16 57.8 1.7 7.1e-16 57.7 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 AIF85153.1 - 3.8e-05 23.1 0.2 5.8e-05 22.5 0.2 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding zinc_ribbon_4 PF13717.6 AIF85153.1 - 0.0029 17.5 1.1 1.6 8.7 0.2 2.2 2 0 0 2 2 2 2 zinc-ribbon domain zf-ACC PF17848.1 AIF85153.1 - 0.0067 16.5 3.7 0.35 11.0 0.2 2.2 2 0 0 2 2 2 2 Acetyl-coA carboxylase zinc finger domain OrfB_Zn_ribbon PF07282.11 AIF85153.1 - 0.0074 16.2 1.6 0.0098 15.8 1.4 1.3 1 1 0 1 1 1 1 Putative transposase DNA-binding domain zf-RING_9 PF13901.6 AIF85153.1 - 0.0096 15.9 0.3 0.01 15.8 0.3 1.2 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon DZR PF12773.7 AIF85153.1 - 0.0099 15.9 0.4 0.013 15.5 0.4 1.2 1 0 0 1 1 1 1 Double zinc ribbon DNA_RNApol_7kD PF03604.13 AIF85153.1 - 0.014 15.0 1.2 0.68 9.7 0.1 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-ribbon_3 PF13248.6 AIF85153.1 - 0.016 14.6 1.4 0.67 9.4 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 AIF85153.1 - 0.02 15.0 0.6 0.031 14.4 0.6 1.3 1 0 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_2 PF13240.6 AIF85153.1 - 0.027 14.2 0.9 1.3 8.8 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 AIF85153.1 - 0.03 14.3 0.5 0.037 14.1 0.5 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_6 PF14599.6 AIF85153.1 - 0.037 14.0 0.3 0.052 13.6 0.3 1.2 1 0 0 1 1 1 0 Zinc-ribbon Zn_Tnp_IS91 PF14319.6 AIF85153.1 - 0.051 13.6 0.6 0.061 13.4 0.6 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain Alpha-amyl_C PF09071.10 AIF85153.1 - 0.056 13.3 0.1 0.17 11.8 0.1 1.7 1 1 0 1 1 1 0 Alpha-amylase, C terminal zf-LSD1 PF06943.12 AIF85153.1 - 0.21 11.5 3.3 1.3 8.9 0.2 2.3 2 0 0 2 2 2 0 LSD1 zinc finger zinc_ribbon_12 PF11331.8 AIF85153.1 - 0.21 11.4 2.7 4.2 7.3 3.2 2.1 1 1 1 2 2 2 0 Probable zinc-ribbon domain TFIIS_C PF01096.18 AIF85153.1 - 0.35 10.7 3.3 6.3 6.7 3.3 2.1 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS) CpXC PF14353.6 AIF85153.1 - 0.38 10.8 2.2 6 6.9 0.2 2.0 1 1 1 2 2 2 0 CpXC protein HalOD2 PF18547.1 AIF85153.1 - 0.49 10.4 5.0 0.47 10.4 0.4 2.1 1 1 1 2 2 2 0 Halobacterial output domain 2 Ribosomal_L44 PF00935.19 AIF85154.1 - 1e-25 90.0 11.0 1e-25 90.0 11.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L44 Ribosomal_L33 PF00471.20 AIF85154.1 - 0.00094 19.6 9.8 0.0017 18.7 0.9 2.3 2 0 0 2 2 2 1 Ribosomal protein L33 NOB1_Zn_bind PF08772.11 AIF85154.1 - 0.0014 18.7 0.6 0.0014 18.7 0.6 2.1 1 1 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like C1_4 PF07975.12 AIF85154.1 - 0.012 15.8 2.9 0.037 14.3 0.2 2.1 2 0 0 2 2 2 0 TFIIH C1-like domain zinc-ribbons_6 PF07191.12 AIF85154.1 - 0.033 14.1 1.5 2.6 8.1 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbons Nudix_N_2 PF14803.6 AIF85154.1 - 0.042 13.8 1.3 2.9 7.9 0.1 2.4 2 0 0 2 2 2 0 Nudix N-terminal zf-FPG_IleRS PF06827.14 AIF85154.1 - 0.11 12.3 3.2 0.79 9.6 0.1 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Rpr2 PF04032.16 AIF85154.1 - 0.16 12.3 5.6 0.32 11.3 5.6 1.5 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DZR PF12773.7 AIF85154.1 - 0.29 11.2 5.4 0.69 10.0 5.4 1.6 1 1 0 1 1 1 0 Double zinc ribbon zf-Dof PF02701.15 AIF85154.1 - 0.32 11.2 8.4 0.22 11.7 0.7 2.6 2 1 0 2 2 2 0 Dof domain, zinc finger zf_UBZ PF18439.1 AIF85154.1 - 3.4 7.3 5.0 8.3 6.1 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 AIF85155.1 - 0.003 17.9 11.3 0.016 15.6 2.6 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zinc_ribbon_5 PF13719.6 AIF85155.1 - 0.0041 16.8 1.2 2.2 8.1 0.0 2.2 2 0 0 2 2 2 2 zinc-ribbon domain zf_UBZ PF18439.1 AIF85155.1 - 0.012 15.2 6.7 0.53 9.9 0.4 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DZR PF12773.7 AIF85155.1 - 0.015 15.3 0.2 0.021 14.8 0.2 1.2 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 AIF85155.1 - 0.019 14.9 2.9 0.35 10.8 2.9 2.1 1 1 0 1 1 1 0 zinc-ribbon domain zf-C2H2_4 PF13894.6 AIF85155.1 - 0.022 15.6 17.0 0.85 10.6 7.5 3.0 3 1 0 3 3 3 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 AIF85155.1 - 0.051 14.3 3.1 0.13 13.0 2.3 1.8 1 1 1 2 2 2 0 zinc-ribbon family c-SKI_SMAD_bind PF08782.10 AIF85155.1 - 0.17 12.1 8.5 2.7 8.3 1.0 2.1 1 1 1 2 2 2 0 c-SKI Smad4 binding domain FUR PF01475.19 AIF85155.1 - 0.29 11.3 8.8 0.34 11.1 8.8 1.3 1 1 0 1 1 1 0 Ferric uptake regulator family Zn-ribbon_8 PF09723.10 AIF85155.1 - 0.36 11.0 5.5 0.53 10.5 3.6 2.0 1 1 1 2 2 2 0 Zinc ribbon domain FYVE PF01363.21 AIF85155.1 - 4.8 7.4 10.5 10 6.4 10.5 1.6 1 1 0 1 1 1 0 FYVE zinc finger 4HBT PF03061.22 AIF85156.1 - 0.04 14.3 0.2 0.12 12.7 0.0 1.8 1 1 1 2 2 2 0 Thioesterase superfamily Cpn60_TCP1 PF00118.24 AIF85157.1 - 3.8e-183 609.6 20.4 4.4e-183 609.4 20.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ustilago_mating PF05722.12 AIF85157.1 - 0.049 13.2 0.2 0.38 10.2 0.0 2.1 2 0 0 2 2 2 0 Ustilago B locus mating-type protein Pyr_redox_3 PF13738.6 AIF85157.1 - 0.079 12.2 0.1 0.18 11.0 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Minor_tail_Z PF06763.11 AIF85157.1 - 0.089 12.6 1.2 0.18 11.6 0.2 2.0 2 0 0 2 2 2 0 Prophage minor tail protein Z (GPZ) PfkB PF00294.24 AIF85158.1 - 1e-16 61.1 0.6 1.4e-16 60.7 0.6 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Pyr_redox PF00070.27 AIF85158.1 - 0.036 14.6 0.0 0.29 11.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ADP_PFK_GK PF04587.15 AIF85158.1 - 0.044 12.4 0.0 0.99 7.9 0.0 2.1 2 0 0 2 2 2 0 ADP-specific Phosphofructokinase/Glucokinase conserved region AglB_L1 PF18079.1 AIF85159.1 - 0.027 14.7 0.1 0.028 14.7 0.1 1.2 1 0 0 1 1 1 0 Archaeal glycosylation protein B long peripheral domain DUF4108 PF13390.6 AIF85161.1 - 0.046 13.6 0.1 0.049 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4108) Scaffolding_pro PF11418.8 AIF85161.1 - 0.078 13.5 0.0 0.088 13.4 0.0 1.2 1 0 0 1 1 1 0 Phi29 scaffolding protein Copper-bind PF00127.20 AIF85162.1 - 2.1e-09 37.7 1.4 4.9e-09 36.5 0.8 2.0 1 1 1 2 2 2 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF85162.1 - 0.0074 16.4 1.1 0.017 15.2 0.2 2.0 2 1 0 2 2 2 1 Cupredoxin-like domain DLH PF01738.18 AIF85163.1 - 5.1e-57 192.9 0.0 6.3e-57 192.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 AIF85163.1 - 1.9e-11 43.9 0.1 1.2e-05 24.9 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family BAAT_C PF08840.11 AIF85163.1 - 1.1e-09 38.6 1.2 0.0046 16.9 0.0 3.3 2 1 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Chlorophyllase2 PF12740.7 AIF85163.1 - 6e-06 25.4 0.0 9.3e-06 24.7 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 AIF85163.1 - 1.2e-05 24.5 0.0 1.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Abhydrolase_2 PF02230.16 AIF85163.1 - 0.0032 17.3 0.0 0.0057 16.5 0.0 1.4 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase NAD_binding_2 PF03446.15 AIF85163.1 - 0.016 15.4 0.2 0.15 12.2 0.1 2.0 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Abhydrolase_5 PF12695.7 AIF85163.1 - 0.03 14.1 0.0 0.097 12.4 0.0 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family PAF-AH_p_II PF03403.13 AIF85163.1 - 0.031 12.8 0.0 0.5 8.8 0.0 2.0 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DUF3185 PF11381.8 AIF85163.1 - 0.7 9.9 3.1 4.8 7.3 1.5 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3185) BPD_transp_1 PF00528.22 AIF85164.1 - 1.9e-14 53.9 17.8 1.9e-14 53.9 17.8 2.0 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 AIF85165.1 - 1.3e-30 106.7 0.0 2.7e-30 105.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIF85165.1 - 4.4e-09 36.6 0.3 0.00071 19.5 0.1 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIF85165.1 - 4.2e-05 23.1 0.5 0.09 12.2 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 AIF85165.1 - 7.2e-05 21.8 0.1 0.0093 14.8 0.0 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class Rad17 PF03215.15 AIF85165.1 - 0.00011 22.1 0.0 0.00042 20.3 0.0 1.8 2 0 0 2 2 2 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 AIF85165.1 - 0.00013 21.9 0.0 0.00025 21.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 AIF85165.1 - 0.00083 19.8 0.9 0.0037 17.7 0.5 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA PF00004.29 AIF85165.1 - 0.00091 19.7 0.4 0.013 15.9 0.4 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 AIF85165.1 - 0.0016 18.2 0.0 0.0036 17.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 AIF85165.1 - 0.0063 16.8 0.8 0.014 15.6 0.2 2.1 2 1 0 2 2 1 1 AAA domain AAA_25 PF13481.6 AIF85165.1 - 0.013 15.1 0.1 0.065 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 AIF85165.1 - 0.02 15.4 0.0 0.049 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 AIF85165.1 - 0.027 14.4 0.0 0.057 13.3 0.0 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 AIF85165.1 - 0.03 14.4 0.2 0.13 12.3 0.1 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_28 PF13521.6 AIF85165.1 - 0.051 13.8 0.2 0.14 12.4 0.2 2.0 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.22 AIF85165.1 - 0.061 12.5 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain T2SSE PF00437.20 AIF85165.1 - 0.062 12.4 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_15 PF13175.6 AIF85165.1 - 0.063 13.0 0.1 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 AIF85165.1 - 0.085 13.0 0.5 0.4 10.8 0.5 2.4 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 AIF85165.1 - 0.11 11.9 0.0 0.35 10.3 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_30 PF13604.6 AIF85165.1 - 0.13 12.0 0.1 0.59 9.8 0.0 2.0 3 0 0 3 3 3 0 AAA domain Stealth_CR3 PF17102.5 AIF85165.1 - 0.13 12.2 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Stealth protein CR3, conserved region 3 RNA_helicase PF00910.22 AIF85165.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase SbcCD_C PF13558.6 AIF85165.1 - 0.18 12.0 0.3 0.75 10.1 0.3 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NMT1_2 PF13379.6 AIF85166.1 - 1.4e-27 97.1 0.1 2e-27 96.5 0.1 1.2 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 AIF85166.1 - 2e-14 54.1 0.1 3.6e-14 53.2 0.1 1.5 1 1 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 AIF85166.1 - 3.2e-11 43.3 0.0 7.1e-11 42.2 0.0 1.6 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 AIF85166.1 - 5.3e-06 26.0 0.0 0.023 14.1 0.0 2.4 1 1 1 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 NMT1_3 PF16868.5 AIF85166.1 - 0.064 12.7 0.1 0.14 11.5 0.0 1.6 2 0 0 2 2 2 0 NMT1-like family ComA PF02679.15 AIF85167.1 - 4.9e-60 203.0 0.4 1.1e-59 201.9 0.1 1.6 2 0 0 2 2 2 1 (2R)-phospho-3-sulfolactate synthase (ComA) MarR_2 PF12802.7 AIF85167.1 - 0.0002 21.2 0.0 0.00039 20.2 0.0 1.5 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIF85167.1 - 0.00043 20.1 0.0 0.0011 18.9 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_43 PF09904.9 AIF85167.1 - 0.0098 15.8 0.2 0.037 14.0 0.0 2.0 3 0 0 3 3 3 1 Winged helix-turn helix HTH_11 PF08279.12 AIF85167.1 - 0.059 13.3 0.0 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 HTH domain HTH_24 PF13412.6 AIF85167.1 - 0.087 12.4 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding AAA_10 PF12846.7 AIF85167.1 - 0.1 11.5 0.3 0.2 10.5 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain zinc_ribbon_10 PF10058.9 AIF85168.1 - 0.0025 17.5 1.9 0.0034 17.1 1.9 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein DUF1272 PF06906.11 AIF85168.1 - 0.0075 16.3 3.8 0.0099 15.9 3.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1272) FYVE PF01363.21 AIF85169.1 - 0.00012 22.2 10.1 0.00044 20.3 2.8 2.1 1 1 1 2 2 2 2 FYVE zinc finger zinc-ribbons_6 PF07191.12 AIF85169.1 - 0.00043 20.2 3.0 0.00054 19.9 3.0 1.2 1 0 0 1 1 1 1 zinc-ribbons RecR PF02132.15 AIF85169.1 - 0.0014 18.1 5.4 0.33 10.5 0.7 2.2 2 0 0 2 2 2 2 RecR protein zf-HIT PF04438.16 AIF85169.1 - 0.0031 17.3 6.7 0.0032 17.3 1.8 2.1 2 0 0 2 2 2 1 HIT zinc finger zf-CHY PF05495.12 AIF85169.1 - 0.011 16.2 3.7 0.013 15.9 3.7 1.3 1 0 0 1 1 1 0 CHY zinc finger zf-B_box PF00643.24 AIF85169.1 - 0.057 13.6 1.6 0.057 13.6 1.6 2.4 3 0 0 3 3 3 0 B-box zinc finger ZZ PF00569.17 AIF85169.1 - 0.15 11.9 8.1 9.1 6.2 8.1 2.2 1 1 0 1 1 1 0 Zinc finger, ZZ type DZR PF12773.7 AIF85169.1 - 0.16 12.0 6.6 0.38 10.8 6.6 1.6 1 1 0 1 1 1 0 Double zinc ribbon CpXC PF14353.6 AIF85169.1 - 0.18 11.9 3.3 3.6 7.6 0.6 2.1 1 1 1 2 2 2 0 CpXC protein zf-ribbon_3 PF13248.6 AIF85169.1 - 0.2 11.1 7.4 4.3 6.9 2.5 2.6 2 1 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 AIF85169.1 - 0.26 11.3 6.4 1.4 9.0 6.4 1.9 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PolC_DP2 PF03833.13 AIF85169.1 - 0.33 8.7 0.9 0.33 8.8 0.9 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Zn-ribbon_8 PF09723.10 AIF85169.1 - 0.41 10.8 7.5 1.5 9.0 7.5 2.1 1 1 1 2 2 2 0 Zinc ribbon domain HalOD2 PF18547.1 AIF85169.1 - 0.88 9.5 8.8 19 5.2 8.8 2.4 1 1 0 1 1 1 0 Halobacterial output domain 2 Rubredoxin_2 PF18073.1 AIF85169.1 - 2.3 8.0 11.8 1.8 8.3 5.7 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain AmoC PF04896.12 AIF85171.1 - 6.4e-13 48.5 5.1 8.4e-13 48.2 5.1 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C DUF2975 PF11188.8 AIF85171.1 - 0.046 13.6 7.7 1.7 8.5 7.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) DUF2627 PF11118.8 AIF85172.1 - 0.029 14.9 0.6 0.36 11.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) DUF3185 PF11381.8 AIF85172.1 - 0.031 14.3 1.7 0.5 10.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) Gram_pos_anchor PF00746.21 AIF85172.1 - 0.076 13.0 0.1 0.076 13.0 0.1 1.9 2 0 0 2 2 2 0 LPXTG cell wall anchor motif TarH PF02203.15 AIF85172.1 - 0.1 12.5 0.3 0.15 12.0 0.3 1.2 1 0 0 1 1 1 0 Tar ligand binding domain homologue TMEM132D_C PF15706.5 AIF85172.1 - 0.21 11.4 0.4 0.38 10.6 0.1 1.6 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF3188 PF11384.8 AIF85172.1 - 0.38 10.5 5.0 6.2 6.6 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) Mem_trans PF03547.18 AIF85172.1 - 0.42 9.0 6.6 0.46 8.8 0.5 2.0 1 1 1 2 2 2 0 Membrane transport protein zf-C2H2 PF00096.26 AIF85173.1 - 0.016 15.7 0.4 0.029 14.8 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF85173.1 - 0.23 12.4 0.4 0.5 11.3 0.4 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger SnoaL_2 PF12680.7 AIF85174.1 - 5.5e-07 30.2 0.0 6.6e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIF85174.1 - 0.068 13.6 0.0 0.11 12.9 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) HTH_20 PF12840.7 AIF85175.1 - 8.4e-07 29.0 0.2 8.5e-06 25.7 0.2 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 AIF85175.1 - 0.0033 17.3 0.9 0.023 14.6 0.1 2.2 2 0 0 2 2 2 1 MarR family HTH_Crp_2 PF13545.6 AIF85175.1 - 0.049 13.6 0.2 0.11 12.4 0.2 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_5 PF01022.20 AIF85175.1 - 0.055 13.4 0.3 0.14 12.0 0.3 1.7 1 1 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 AIF85175.1 - 0.083 12.5 0.1 0.8 9.3 0.1 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding PLDc_2 PF13091.6 AIF85175.1 - 0.097 12.6 0.0 0.2 11.6 0.0 1.6 1 1 0 1 1 1 0 PLD-like domain ADH_zinc_N_2 PF13602.6 AIF85176.1 - 5.3e-27 95.5 0.1 1.1e-26 94.5 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 AIF85176.1 - 1.8e-15 57.1 0.1 4.6e-15 55.7 0.1 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AIF85176.1 - 3.6e-11 42.9 0.0 1.1e-10 41.4 0.0 1.9 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Rtt106 PF08512.12 AIF85176.1 - 0.037 14.4 0.1 0.06 13.8 0.1 1.3 1 0 0 1 1 1 0 Histone chaperone Rttp106-like WASH-7_mid PF14744.6 AIF85176.1 - 0.063 12.4 0.1 0.086 11.9 0.1 1.1 1 0 0 1 1 1 0 WASH complex subunit 7 ArsA_HSP20 PF17886.1 AIF85178.1 - 4e-10 39.1 0.1 6.5e-10 38.4 0.1 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HSP20 PF00011.21 AIF85178.1 - 1.2e-08 35.1 0.7 1.4e-06 28.4 0.7 2.3 1 1 0 1 1 1 1 Hsp20/alpha crystallin family GvpH PF05455.11 AIF85178.1 - 0.00086 19.4 1.4 0.00094 19.3 0.6 1.4 2 0 0 2 2 2 1 GvpH CS PF04969.16 AIF85178.1 - 0.052 14.6 0.0 0.082 13.9 0.0 1.3 1 0 0 1 1 1 0 CS domain DUF2258 PF10015.9 AIF85178.1 - 0.14 12.3 0.1 0.33 11.1 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) DnaJ_C PF01556.18 AIF85179.1 - 2.5e-36 125.0 0.0 3.4e-36 124.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AIF85179.1 - 4.3e-28 97.2 3.6 6.8e-28 96.6 3.6 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AIF85179.1 - 1.5e-12 47.7 14.7 2.9e-12 46.8 14.7 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AIF85179.1 - 0.0057 16.6 11.2 0.12 12.4 0.9 3.1 2 1 1 3 3 3 3 Tryptophan RNA-binding attenuator protein inhibitory protein zf-RING_10 PF16685.5 AIF85179.1 - 0.52 10.5 2.9 1.3 9.2 2.9 1.7 1 1 0 1 1 1 0 zinc RING finger of MSL2 HSP70 PF00012.20 AIF85180.1 - 1.2e-214 714.0 15.2 8.3e-196 651.8 9.8 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 AIF85180.1 - 4.3e-16 58.6 4.4 1.3e-15 57.1 4.4 1.8 1 1 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 AIF85180.1 - 3.4e-05 23.7 0.1 7.1e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Iron_permease PF04120.12 AIF85180.1 - 0.031 14.0 1.5 4 7.2 0.1 3.2 3 0 0 3 3 3 0 Low affinity iron permease EELM2 PF15863.5 AIF85180.1 - 0.51 10.4 2.0 0.93 9.6 2.0 1.4 1 0 0 1 1 1 0 Extended EGL-27 and MTA1 homology domain GrpE PF01025.19 AIF85181.1 - 4.8e-40 136.9 6.4 6.3e-40 136.5 6.4 1.2 1 0 0 1 1 1 1 GrpE Jnk-SapK_ap_N PF09744.9 AIF85181.1 - 0.001 19.3 9.1 0.0014 18.8 9.1 1.2 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 Atg14 PF10186.9 AIF85181.1 - 0.0038 16.4 4.9 0.0047 16.1 4.9 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1633 PF07794.11 AIF85181.1 - 0.006 14.8 5.0 0.0074 14.5 5.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1633) AIP3 PF03915.13 AIF85181.1 - 0.026 13.6 4.5 0.034 13.2 4.5 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 DUF3584 PF12128.8 AIF85181.1 - 0.05 11.1 9.8 0.059 10.9 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SspB PF04386.13 AIF85181.1 - 0.2 11.5 0.0 0.2 11.5 0.0 2.3 2 1 0 2 2 2 0 Stringent starvation protein B FUSC PF04632.12 AIF85181.1 - 0.29 9.6 2.3 0.35 9.3 2.3 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Prominin PF05478.11 AIF85181.1 - 0.4 8.6 4.4 0.49 8.3 4.4 1.0 1 0 0 1 1 1 0 Prominin Fmp27_WPPW PF10359.9 AIF85181.1 - 0.94 8.3 5.7 1.1 8.0 5.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF4140 PF13600.6 AIF85181.1 - 1.5 9.3 5.4 4.2 7.9 5.4 1.8 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) HSP70 PF00012.20 AIF85181.1 - 6.5 4.8 10.9 9.1 4.3 10.9 1.1 1 0 0 1 1 1 0 Hsp70 protein Thioredoxin PF00085.20 AIF85182.1 - 4e-28 97.4 0.0 6.1e-28 96.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AIF85182.1 - 1.1e-06 29.0 0.3 1.2e-05 25.7 0.1 2.3 2 1 0 2 2 2 1 Thioredoxin-like domain TraF PF13728.6 AIF85182.1 - 1.7e-05 24.8 0.7 3e-05 24.0 0.1 1.5 1 1 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 AIF85182.1 - 2e-05 24.9 0.0 0.0013 19.0 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 AIF85182.1 - 2.1e-05 24.0 0.0 3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 AIF85182.1 - 0.00024 20.9 0.0 0.00032 20.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 AIF85182.1 - 0.0012 18.6 0.0 0.0078 15.9 0.0 1.9 1 1 1 2 2 2 1 Redoxin Thioredoxin_7 PF13899.6 AIF85182.1 - 0.021 15.0 0.0 0.041 14.1 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like HyaE PF07449.11 AIF85182.1 - 0.024 14.6 0.0 0.058 13.4 0.0 1.6 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 AIF85182.1 - 0.058 13.6 0.1 0.16 12.2 0.0 1.8 2 0 0 2 2 2 0 Glutaredoxin AhpC-TSA PF00578.21 AIF85182.1 - 0.08 12.9 0.0 0.17 11.8 0.0 1.6 1 1 0 1 1 1 0 AhpC/TSA family Thioredoxin_5 PF13743.6 AIF85182.1 - 0.43 10.2 1.7 36 4.0 0.0 2.9 2 1 1 3 3 3 0 Thioredoxin Tom5 PF10642.9 AIF85184.1 - 0.0004 20.4 0.0 0.0012 18.8 0.0 1.9 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase SecA_SW PF07516.13 AIF85184.1 - 0.0053 16.8 0.4 0.024 14.7 0.0 1.9 1 1 1 2 2 2 1 SecA Wing and Scaffold domain Desulfoferrod_N PF06397.12 AIF85185.1 - 0.011 15.4 0.6 0.017 14.8 0.6 1.3 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain DUF2318 PF10080.9 AIF85185.1 - 0.054 13.6 0.4 0.065 13.4 0.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) eIF-5_eIF-2B PF01873.17 AIF85186.1 - 3.1e-30 104.4 0.0 4e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 AIF85186.1 - 1.7e-05 24.3 0.6 2.7e-05 23.6 0.6 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Lar_restr_allev PF14354.6 AIF85186.1 - 0.0014 19.0 0.4 0.002 18.5 0.4 1.3 1 0 0 1 1 1 1 Restriction alleviation protein Lar DpnI PF06044.12 AIF85186.1 - 0.022 14.4 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Dam-replacing family Elf1 PF05129.13 AIF85186.1 - 0.026 14.6 0.1 0.035 14.1 0.1 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-RRN7 PF11781.8 AIF85186.1 - 0.064 13.0 0.7 7.8 6.3 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DNA_ligase_ZBD PF03119.16 AIF85186.1 - 0.065 13.3 1.2 0.1 12.6 0.5 1.7 1 1 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Vps36-NZF-N PF16988.5 AIF85186.1 - 0.072 12.5 0.4 0.13 11.6 0.4 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zinc_ribbon_2 PF13240.6 AIF85186.1 - 0.081 12.7 1.2 5.4 6.9 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 AIF85186.1 - 0.11 12.6 0.1 3.2 8.0 0.0 2.2 2 0 0 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 AIF85186.1 - 0.12 11.8 0.8 2.8 7.5 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Prim_Zn_Ribbon PF08273.12 AIF85186.1 - 0.14 12.5 2.8 0.17 12.2 1.5 1.8 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase Cys_rich_KTR PF14205.6 AIF85186.1 - 0.36 10.7 2.3 0.83 9.5 0.2 2.3 2 1 1 3 3 3 0 Cysteine-rich KTR Prok-RING_1 PF14446.6 AIF85186.1 - 0.42 10.6 4.4 0.37 10.7 0.5 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 Glycos_transf_2 PF00535.26 AIF85187.1 - 2.6e-31 108.7 0.2 4.5e-31 107.9 0.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIF85187.1 - 1.4e-22 80.8 0.1 1.2e-21 77.7 0.1 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 AIF85187.1 - 1.9e-18 66.4 0.7 1.4e-17 63.5 0.5 1.9 1 1 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 AIF85187.1 - 5.5e-12 46.0 5.4 5.5e-12 46.0 5.4 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 AIF85187.1 - 5.4e-05 22.7 0.1 0.0049 16.4 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 AIF85187.1 - 0.0019 17.7 0.1 0.0029 17.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AIF85187.1 - 0.0027 18.2 0.0 0.0065 17.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_5 PF13712.6 AIF85187.1 - 0.036 13.7 0.0 0.071 12.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family Fringe PF02434.16 AIF85187.1 - 0.14 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Fringe-like NTP_transferase PF00483.23 AIF85187.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyl transferase UDPG_MGDP_dh PF00984.19 AIF85188.1 - 1.9e-20 72.8 0.0 3.4e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 AIF85188.1 - 6e-08 32.5 0.0 0.012 15.2 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 AIF85188.1 - 0.00014 22.1 0.0 0.00026 21.2 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 AIF85188.1 - 0.00027 20.9 0.1 0.00062 19.7 0.1 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIF85188.1 - 0.0042 16.5 0.0 0.0067 15.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPMT PF05724.11 AIF85188.1 - 0.014 15.0 0.0 0.026 14.2 0.0 1.6 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Coatomer_b_Cpla PF14806.6 AIF85188.1 - 0.016 15.2 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Coatomer beta subunit appendage platform Methyltransf_23 PF13489.6 AIF85188.1 - 0.027 14.3 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Antimicrobial20 PF08256.11 AIF85188.1 - 0.81 10.4 2.3 72 4.4 1.2 2.9 2 0 0 2 2 2 0 Aurein-like antibiotic peptide zf-C2H2_2 PF12756.7 AIF85189.1 - 0.02 15.2 0.1 0.024 15.0 0.1 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Glycos_transf_2 PF00535.26 AIF85190.1 - 6.5e-32 110.7 0.1 9.7e-32 110.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIF85190.1 - 3.5e-24 86.0 0.4 5.3e-23 82.1 0.4 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 AIF85190.1 - 8.5e-18 64.3 0.4 2.1e-17 63.0 0.4 1.5 1 1 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 AIF85190.1 - 6.4e-13 49.1 6.2 6.4e-13 49.1 6.2 2.5 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 AIF85190.1 - 7.4e-07 28.8 0.4 0.00013 21.4 0.0 2.5 2 1 1 3 3 3 2 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 AIF85190.1 - 2.1e-05 24.2 0.1 3.2e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AIF85190.1 - 0.0091 16.5 0.0 0.021 15.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_5 PF13712.6 AIF85190.1 - 0.027 14.1 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase like family TraP PF07296.11 AIF85190.1 - 0.1 11.8 2.1 0.74 9.0 0.5 2.2 2 0 0 2 2 2 0 TraP protein HXXEE PF13787.6 AIF85190.1 - 0.15 12.9 6.8 0.21 12.4 1.6 2.6 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif Polysacc_deac_1 PF01522.21 AIF85191.1 - 1.4e-14 54.0 0.0 2.1e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase UDPG_MGDP_dh PF00984.19 AIF85192.1 - 2.4e-20 72.5 0.0 4.1e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 AIF85192.1 - 1.7e-08 34.3 0.0 0.0032 17.1 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 AIF85192.1 - 0.00017 21.8 0.0 0.00038 20.7 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 AIF85192.1 - 0.00027 20.9 0.5 0.00049 20.0 0.1 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIF85192.1 - 0.00071 19.0 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPMT PF05724.11 AIF85192.1 - 0.0041 16.8 0.0 0.0068 16.1 0.0 1.4 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) NAD_binding_7 PF13241.6 AIF85192.1 - 0.06 13.8 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Coatomer_b_Cpla PF14806.6 AIF85192.1 - 0.096 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Coatomer beta subunit appendage platform DegT_DnrJ_EryC1 PF01041.17 AIF85193.1 - 2.8e-120 402.0 0.5 3.1e-120 401.8 0.5 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 AIF85193.1 - 5e-08 32.5 0.0 9.4e-08 31.6 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 AIF85193.1 - 1.7e-05 23.6 0.1 2.7e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.20 AIF85193.1 - 0.00089 18.1 0.0 0.0012 17.7 0.0 1.2 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Beta_elim_lyase PF01212.21 AIF85193.1 - 0.0016 17.7 1.9 0.0043 16.4 1.9 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase ComK PF06338.11 AIF85193.1 - 0.0067 16.1 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 ComK protein Ammonium_transp PF00909.21 AIF85194.1 - 3.6e-111 371.7 29.8 4.1e-111 371.5 29.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3188 PF11384.8 AIF85194.1 - 2.9 7.7 6.1 1.1 9.0 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3188) ArsA_ATPase PF02374.15 AIF85195.1 - 4.8e-67 226.3 0.0 5.6e-67 226.1 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.23 AIF85195.1 - 1.9e-08 34.4 0.0 3.4e-08 33.6 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 AIF85195.1 - 1.5e-07 31.5 0.0 3.2e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain ArsA_HSP20 PF17886.1 AIF85195.1 - 1.2e-06 28.0 0.0 2.5e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 HSP20-like domain found in ArsA ParA PF10609.9 AIF85195.1 - 0.00015 21.3 0.0 0.0012 18.4 0.0 2.1 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 AIF85195.1 - 0.0002 20.9 0.0 0.00033 20.2 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MeaB PF03308.16 AIF85195.1 - 0.023 13.7 0.0 0.049 12.6 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 AIF85195.1 - 0.07 12.9 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.16 AIF85195.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Fer4_7 PF12838.7 AIF85196.1 - 1.9e-09 37.9 2.5 0.0002 21.9 0.6 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 AIF85196.1 - 4.3e-09 35.8 12.2 5.5e-06 26.0 1.6 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 AIF85196.1 - 3.9e-08 33.3 16.2 1.7e-07 31.2 5.8 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIF85196.1 - 8e-07 29.9 16.3 5.4e-05 24.1 7.8 2.1 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 AIF85196.1 - 1.3e-06 28.4 7.4 1.5e-05 25.0 8.2 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIF85196.1 - 3.8e-06 27.2 5.6 0.0014 19.1 8.6 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIF85196.1 - 1.6e-05 24.8 12.6 0.011 15.7 1.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 AIF85196.1 - 3.1e-05 24.4 4.9 0.066 13.8 0.1 2.7 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_21 PF14697.6 AIF85196.1 - 4e-05 23.7 9.4 0.0084 16.2 9.5 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 AIF85196.1 - 0.00012 22.6 4.7 0.0019 18.7 5.9 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIF85196.1 - 0.00038 20.4 10.7 0.039 14.0 3.2 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 AIF85196.1 - 0.00042 20.6 6.1 0.036 14.6 1.3 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 AIF85196.1 - 0.0089 16.7 7.7 0.24 12.2 2.5 2.5 2 1 0 2 2 2 2 4Fe-4S single cluster domain Fer4_22 PF17179.4 AIF85196.1 - 0.01 16.6 0.5 5.8 7.8 0.1 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 AIF85196.1 - 0.01 16.0 8.6 0.031 14.5 6.5 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIF85196.1 - 0.072 14.1 14.9 1.7 9.7 6.4 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain TIG PF01833.24 AIF85200.1 - 0.0001 22.3 0.1 0.00015 21.7 0.1 1.3 1 0 0 1 1 1 1 IPT/TIG domain MG2 PF01835.19 AIF85200.1 - 0.00044 20.6 0.1 0.00058 20.3 0.1 1.5 1 1 0 1 1 1 1 MG2 domain CarboxypepD_reg PF13620.6 AIF85200.1 - 0.0017 18.6 0.3 0.0033 17.7 0.3 1.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Peptidase_M23_N PF18421.1 AIF85200.1 - 0.0025 17.7 0.0 0.0038 17.1 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M23 N-terminal domain BiPBP_C PF06832.12 AIF85200.1 - 0.019 15.0 0.1 0.07 13.2 0.1 2.0 1 1 1 2 2 2 0 Penicillin-Binding Protein C-terminus Family DUF4625 PF15418.6 AIF85200.1 - 0.034 14.4 1.0 0.3 11.3 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4625) DUF5016 PF16408.5 AIF85200.1 - 0.072 13.1 0.8 0.11 12.5 0.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5016) FliD_N PF02465.18 AIF85200.1 - 0.087 13.5 2.2 0.41 11.4 2.2 2.0 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus BNR_2 PF13088.6 AIF85202.1 - 1.4e-06 27.8 0.0 0.00015 21.2 0.0 3.3 2 1 0 2 2 2 2 BNR repeat-like domain BNR PF02012.20 AIF85202.1 - 0.0041 16.9 7.2 2.9 8.3 0.0 5.8 6 0 0 6 6 6 1 BNR/Asp-box repeat DUF1697 PF08002.11 AIF85203.1 - 1.3e-38 132.5 0.0 1.7e-38 132.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1697) 3-dmu-9_3-mt PF06983.13 AIF85204.1 - 3.2e-69 230.8 0.3 1.1e-43 148.5 0.2 2.0 2 0 0 2 2 2 2 3-demethylubiquinone-9 3-methyltransferase Glyoxalase PF00903.25 AIF85204.1 - 1.6e-05 25.1 0.0 0.00069 19.8 0.0 2.7 2 1 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PepSY_TM_like_2 PF16357.5 AIF85205.1 - 0.48 10.4 3.6 3.6 7.5 3.0 2.0 2 0 0 2 2 2 0 Putative PepSY_TM-like Pyridox_ox_2 PF12900.7 AIF85207.1 - 2e-11 44.0 0.0 2.4e-11 43.8 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 AIF85207.1 - 6e-11 42.4 0.0 9.8e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase LSM_int_assoc PF16605.5 AIF85207.1 - 0.042 14.0 0.0 0.084 13.0 0.0 1.5 1 0 0 1 1 1 0 LSM-interacting associated unstructured HypD PF01924.16 AIF85208.1 - 0.12 11.5 1.4 0.15 11.1 1.4 1.1 1 0 0 1 1 1 0 Hydrogenase formation hypA family Bactofilin PF04519.13 AIF85211.1 - 0.048 14.0 0.4 1.3 9.3 0.0 2.3 2 1 0 2 2 2 0 Polymer-forming cytoskeletal DUF629 PF04780.12 AIF85213.1 - 0.057 11.9 0.2 0.057 11.9 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-C2H2_4 PF13894.6 AIF85213.1 - 0.065 14.1 0.8 0.12 13.3 0.2 1.7 2 0 0 2 2 2 0 C2H2-type zinc finger YtkA PF13115.6 AIF85214.1 - 0.024 15.2 0.2 0.2 12.3 0.0 2.0 2 0 0 2 2 2 0 YtkA-like VCX_VCY PF15231.6 AIF85215.1 - 0.057 14.1 0.0 0.073 13.8 0.0 1.1 1 0 0 1 1 1 0 Variable charge X/Y family CBS PF00571.28 AIF85216.1 - 3e-35 120.5 7.0 4.1e-08 33.5 0.2 4.3 4 0 0 4 4 4 4 CBS domain Ribosomal_S30AE PF02482.19 AIF85216.1 - 0.00041 21.1 1.6 0.0012 19.5 1.6 1.8 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein DUF2228 PF10228.9 AIF85216.1 - 0.064 13.0 1.9 0.15 11.8 0.8 1.9 1 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) GSDH PF07995.11 AIF85217.1 - 7.9e-90 301.5 0.0 1.4e-89 300.6 0.0 1.4 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase DUF5122 PF17164.4 AIF85217.1 - 0.0041 17.4 0.0 0.02 15.2 0.0 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF5122) beta-propeller Reg_prop PF07494.11 AIF85217.1 - 0.029 14.6 0.0 17 6.0 0.0 3.7 3 0 0 3 3 3 0 Two component regulator propeller adh_short PF00106.25 AIF85219.1 - 8.4e-51 172.2 0.3 1.4e-50 171.5 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIF85219.1 - 1.6e-38 132.6 0.1 2.2e-38 132.1 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIF85219.1 - 5.2e-11 42.8 0.1 8.4e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 AIF85219.1 - 2.4e-06 27.1 0.0 1.8e-05 24.3 0.0 2.0 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.8 AIF85219.1 - 0.00072 19.3 0.4 0.003 17.3 0.1 2.1 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NmrA PF05368.13 AIF85219.1 - 0.011 15.3 0.2 0.21 11.1 0.1 2.0 2 0 0 2 2 2 0 NmrA-like family Patatin PF01734.22 AIF85219.1 - 0.057 13.6 0.2 0.096 12.9 0.1 1.6 1 1 0 1 1 1 0 Patatin-like phospholipase MFS_1 PF07690.16 AIF85220.1 - 3.6e-49 167.6 69.3 3.7e-45 154.4 44.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AIF85220.1 - 9.2e-12 44.5 7.6 9.2e-12 44.5 7.6 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 AIF85220.1 - 0.037 12.3 12.8 0.51 8.6 0.0 3.6 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Cupredoxin_1 PF13473.6 AIF85221.1 - 1.9e-09 37.5 0.1 3.4e-09 36.7 0.1 1.4 1 1 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 AIF85221.1 - 4.8e-08 33.4 0.0 7.4e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family HMG-CoA_red PF00368.18 AIF85223.1 - 1.3e-105 353.4 13.0 1.7e-105 353.0 13.0 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase DUF3759 PF12585.8 AIF85223.1 - 0.88 9.6 4.9 4.5 7.4 4.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3759) HisG PF01634.18 AIF85224.1 - 4.7e-43 146.9 0.1 6.3e-43 146.5 0.1 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 AIF85224.1 - 4.7e-16 58.7 0.0 1.3e-15 57.3 0.0 1.7 2 0 0 2 2 2 1 HisG, C-terminal domain Histidinol_dh PF00815.20 AIF85225.1 - 2e-138 461.8 5.6 2.3e-138 461.6 5.6 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase FlbD PF06289.11 AIF85225.1 - 0.11 12.1 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 Flagellar and Swarming motility proteins Aminotran_1_2 PF00155.21 AIF85226.1 - 2.2e-45 155.4 0.0 2.6e-45 155.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 AIF85226.1 - 1.5e-08 33.9 0.0 2.5e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Allinase PC_rep PF01851.22 AIF85226.1 - 0.0096 16.3 0.1 0.027 14.9 0.1 1.8 1 0 0 1 1 1 1 Proteasome/cyclosome repeat DUF1919 PF08942.10 AIF85226.1 - 0.033 13.6 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1919) HAD_2 PF13419.6 AIF85227.1 - 9.9e-12 45.3 0.1 2e-06 28.0 0.0 2.2 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AIF85227.1 - 7.8e-10 39.4 0.2 2.2e-09 37.9 0.2 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AIF85227.1 - 0.025 14.6 0.2 0.085 12.9 0.1 1.9 2 0 0 2 2 2 0 HAD-hyrolase-like PNK3P PF08645.11 AIF85227.1 - 0.033 13.9 0.7 5.6 6.6 0.0 2.5 2 1 0 2 2 2 0 Polynucleotide kinase 3 phosphatase OrfB_Zn_ribbon PF07282.11 AIF85228.1 - 2.1e-23 82.0 1.9 3.5e-23 81.3 1.9 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain OrfB_IS605 PF01385.19 AIF85228.1 - 1.3e-07 31.8 0.4 8.7e-07 29.2 0.2 2.3 1 1 0 1 1 1 1 Probable transposase RuvC_1 PF18516.1 AIF85228.1 - 2e-06 27.2 2.6 1.8e-05 24.0 2.6 2.1 1 1 0 1 1 1 1 RuvC nuclease domain MMS19_N PF14500.6 AIF85228.1 - 0.011 15.4 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Rep_fac-A_C PF08646.10 AIF85228.1 - 0.12 12.1 1.0 0.2 11.4 1.0 1.3 1 0 0 1 1 1 0 Replication factor-A C terminal domain DUF3155 PF11352.8 AIF85228.1 - 0.14 12.6 0.4 3.7 8.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3155) Zn_Tnp_IS1595 PF12760.7 AIF85228.1 - 0.23 11.5 3.1 0.43 10.6 3.1 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain IGPD PF00475.18 AIF85230.1 - 9e-43 146.0 1.2 9e-43 146.0 1.2 1.3 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase GATase PF00117.28 AIF85231.1 - 4.3e-23 82.1 0.0 4.8e-23 81.9 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIF85231.1 - 3.5e-09 36.7 0.0 1.5e-07 31.4 0.0 2.3 1 1 0 1 1 1 1 Peptidase C26 GATase_3 PF07685.14 AIF85231.1 - 5.1e-09 36.0 0.0 5.5e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 AIF85231.1 - 8.4e-07 29.0 0.0 0.0029 17.5 0.0 2.0 2 0 0 2 2 2 2 SNO glutamine amidotransferase family DJ-1_PfpI PF01965.24 AIF85231.1 - 0.0019 18.0 0.0 0.0038 17.0 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family His_biosynth PF00977.21 AIF85232.1 - 9.9e-68 228.0 5.7 1.1e-67 227.8 5.7 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein PcrB PF01884.17 AIF85232.1 - 4.7e-09 36.0 3.0 4.3e-05 23.1 0.2 2.2 2 0 0 2 2 2 2 PcrB family Dus PF01207.17 AIF85232.1 - 3.3e-07 29.7 0.4 9.2e-05 21.7 0.1 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 AIF85232.1 - 7.3e-07 28.7 2.1 0.00036 19.8 1.5 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase FMN_dh PF01070.18 AIF85232.1 - 0.00022 20.4 3.2 0.0075 15.3 0.3 2.1 2 0 0 2 2 2 2 FMN-dependent dehydrogenase NanE PF04131.14 AIF85232.1 - 0.00073 18.8 1.6 0.24 10.5 0.1 2.3 2 0 0 2 2 2 2 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.14 AIF85232.1 - 0.0011 18.3 3.7 0.0069 15.7 0.4 2.2 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 AIF85232.1 - 0.0012 17.9 8.2 0.032 13.2 0.6 2.2 1 1 2 3 3 3 3 IMP dehydrogenase / GMP reductase domain IGPS PF00218.21 AIF85232.1 - 0.0013 17.9 0.3 1.4 8.0 0.0 2.5 2 1 0 2 2 2 2 Indole-3-glycerol phosphate synthase DUF4406 PF14359.6 AIF85232.1 - 0.023 15.1 0.0 0.048 14.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4406) CutC PF03932.14 AIF85232.1 - 0.038 13.4 0.7 4.4 6.7 0.0 2.7 2 1 1 3 3 3 0 CutC family Endonuc-HincII PF09226.11 AIF85232.1 - 0.066 12.5 0.0 0.094 12.0 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease HincII Trp_syntA PF00290.20 AIF85232.1 - 0.079 11.8 1.9 0.12 11.2 0.2 2.0 2 0 0 2 2 2 0 Tryptophan synthase alpha chain G3P_antiterm PF04309.12 AIF85232.1 - 0.18 11.2 3.0 2.9 7.3 0.2 2.5 2 1 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator His_biosynth PF00977.21 AIF85233.1 - 6.5e-87 290.8 1.2 7.6e-87 290.6 1.2 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.17 AIF85233.1 - 7.8e-08 31.8 0.1 0.00048 19.3 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.15 AIF85233.1 - 3.8e-07 29.8 0.8 0.011 15.1 0.0 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase ThiG PF05690.14 AIF85233.1 - 1.8e-05 24.2 0.6 0.041 13.2 0.2 2.1 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 AIF85233.1 - 0.00021 20.6 0.2 0.49 9.7 0.0 2.4 2 0 0 2 2 2 2 Thiamine monophosphate synthase PcrB PF01884.17 AIF85233.1 - 0.0024 17.4 0.4 0.055 12.9 0.1 2.2 2 0 0 2 2 2 1 PcrB family G3P_antiterm PF04309.12 AIF85233.1 - 0.0024 17.3 0.2 0.13 11.7 0.1 2.2 2 0 0 2 2 2 1 Glycerol-3-phosphate responsive antiterminator DHO_dh PF01180.21 AIF85233.1 - 0.0027 17.0 0.1 0.063 12.5 0.1 2.1 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase Trp_syntA PF00290.20 AIF85233.1 - 0.024 13.5 0.2 0.042 12.7 0.2 1.4 1 0 0 1 1 1 0 Tryptophan synthase alpha chain Acylphosphatase PF00708.18 AIF85235.1 - 6.4e-26 90.6 0.1 6.9e-26 90.5 0.1 1.0 1 0 0 1 1 1 1 Acylphosphatase Orn_Arg_deC_N PF02784.16 AIF85236.1 - 3.2e-38 131.5 0.0 4.2e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 AIF85236.1 - 4.7e-10 39.6 0.0 5.6e-10 39.3 0.0 1.3 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AAA PF00004.29 AIF85237.1 - 7.8e-100 330.5 0.2 5.4e-51 172.5 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.18 AIF85237.1 - 1.8e-31 108.1 0.4 5.2e-31 106.7 0.4 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_lid_3 PF17862.1 AIF85237.1 - 1e-23 82.8 0.1 1e-12 47.7 0.0 2.9 2 1 0 2 2 2 2 AAA+ lid domain AAA_2 PF07724.14 AIF85237.1 - 7.6e-18 65.2 0.0 3.7e-08 33.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AIF85237.1 - 1.8e-15 57.0 0.0 3.3e-09 36.7 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AIF85237.1 - 1.6e-14 54.7 0.2 2.4e-06 28.0 0.0 3.7 2 2 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.13 AIF85237.1 - 4.9e-11 42.4 0.1 0.00016 21.0 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 AIF85237.1 - 2.1e-10 41.0 1.4 0.002 18.4 0.1 4.3 3 2 0 3 3 2 2 AAA domain AAA_33 PF13671.6 AIF85237.1 - 2.9e-10 40.5 0.0 0.00062 19.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 AIF85237.1 - 3e-10 40.2 1.3 0.00018 21.5 0.1 4.1 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 AIF85237.1 - 1.2e-09 38.3 0.0 0.00013 22.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.17 AIF85237.1 - 5.1e-09 35.8 0.1 1.3e-08 34.5 0.1 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 Sigma54_activat PF00158.26 AIF85237.1 - 8.3e-08 32.1 0.3 0.035 13.8 0.0 3.5 3 1 0 3 3 3 2 Sigma-54 interaction domain IstB_IS21 PF01695.17 AIF85237.1 - 8.9e-08 32.1 0.0 0.0073 16.0 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein Bac_DnaA PF00308.18 AIF85237.1 - 5.3e-07 29.7 0.0 0.00084 19.2 0.0 2.6 2 0 0 2 2 2 1 Bacterial dnaA protein RNA_helicase PF00910.22 AIF85237.1 - 1.6e-06 28.5 0.0 0.042 14.2 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 AIF85237.1 - 1.7e-06 27.6 2.2 0.039 13.3 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ATPase PF06745.13 AIF85237.1 - 2.1e-06 27.3 1.9 0.12 11.8 0.0 3.8 3 1 1 4 4 3 2 KaiC AAA_7 PF12775.7 AIF85237.1 - 2.3e-06 27.2 0.1 0.037 13.5 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 AIF85237.1 - 4.2e-06 26.6 0.0 0.024 14.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 AIF85237.1 - 4.6e-06 26.7 0.0 0.094 12.7 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 AIF85237.1 - 5.7e-06 26.7 0.0 0.029 14.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 AIF85237.1 - 9.2e-06 25.7 0.1 0.18 11.7 0.1 3.6 4 0 0 4 4 3 2 NACHT domain AAA_18 PF13238.6 AIF85237.1 - 1.3e-05 25.8 0.0 0.033 14.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 AIF85237.1 - 1.5e-05 24.3 0.1 0.15 11.3 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin PhoH PF02562.16 AIF85237.1 - 3.7e-05 23.3 0.4 0.29 10.6 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein DUF815 PF05673.13 AIF85237.1 - 7.7e-05 22.0 0.0 0.052 12.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATPase_2 PF01637.18 AIF85237.1 - 9e-05 22.5 0.1 0.029 14.3 0.0 3.1 3 1 0 3 3 2 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 AIF85237.1 - 0.0001 22.8 0.0 0.8 10.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_25 PF13481.6 AIF85237.1 - 0.00023 20.8 5.3 1.3 8.6 0.2 3.7 2 2 1 3 3 3 1 AAA domain NB-ARC PF00931.22 AIF85237.1 - 0.00033 19.9 0.1 0.43 9.7 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain Cytidylate_kin PF02224.18 AIF85237.1 - 0.00049 19.9 0.1 0.45 10.2 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase AAA_3 PF07726.11 AIF85237.1 - 0.00096 19.0 0.0 0.53 10.1 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 AIF85237.1 - 0.0015 17.9 0.0 0.38 9.9 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 AIF85237.1 - 0.0016 18.2 0.7 1.9 8.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.17 AIF85237.1 - 0.0017 17.5 0.1 0.31 10.1 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 TniB PF05621.11 AIF85237.1 - 0.002 17.5 0.0 0.82 9.1 0.0 2.9 3 0 0 3 3 3 1 Bacterial TniB protein AAA_11 PF13086.6 AIF85237.1 - 0.0027 17.5 0.0 0.65 9.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AFG1_ATPase PF03969.16 AIF85237.1 - 0.0031 16.5 0.1 0.83 8.5 0.0 2.6 3 0 0 3 3 3 1 AFG1-like ATPase Guanylate_kin PF00625.21 AIF85237.1 - 0.009 15.7 0.2 6.9 6.3 0.0 3.4 2 1 1 3 3 3 0 Guanylate kinase AAA_17 PF13207.6 AIF85237.1 - 0.013 15.9 0.0 1.1 9.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 AIF85237.1 - 0.019 15.1 0.0 1.9 8.6 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 AIF85237.1 - 0.021 14.7 0.9 11 5.9 0.0 3.5 2 1 1 3 3 3 0 NTPase PduV-EutP PF10662.9 AIF85237.1 - 0.023 14.4 0.1 12 5.6 0.0 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation T2SSE PF00437.20 AIF85237.1 - 0.024 13.7 0.1 6.1 5.8 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein ATP-synt_ab PF00006.25 AIF85237.1 - 0.029 14.0 0.0 4.9 6.7 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ResIII PF04851.15 AIF85237.1 - 0.031 14.3 0.0 9.9 6.1 0.0 2.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_29 PF13555.6 AIF85237.1 - 0.032 14.0 0.4 5.8 6.7 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 AIF85237.1 - 0.035 13.8 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF1905 PF08922.11 AIF85237.1 - 0.036 14.1 0.0 0.095 12.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1905) Vps4_C PF09336.10 AIF85237.1 - 0.042 13.8 0.5 2.3 8.3 0.1 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain Rad17 PF03215.15 AIF85237.1 - 0.052 13.5 0.1 28 4.5 0.0 3.1 2 1 1 3 3 3 0 Rad17 P-loop domain CPT PF07931.12 AIF85237.1 - 0.06 13.2 0.0 6.3 6.6 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein SKI PF01202.22 AIF85237.1 - 0.078 13.1 0.1 8.4 6.5 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase IPT PF01745.16 AIF85237.1 - 0.11 11.9 0.2 12 5.1 0.0 2.4 2 0 0 2 2 2 0 Isopentenyl transferase AAA_19 PF13245.6 AIF85237.1 - 0.12 12.7 2.8 3.4 8.0 0.1 3.1 2 1 1 3 3 2 0 AAA domain PIF1 PF05970.14 AIF85237.1 - 0.18 10.9 0.0 20 4.2 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase ECR1_N PF14382.6 AIF85238.1 - 1.6e-05 24.6 0.0 3.1e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.9 AIF85238.1 - 0.012 16.2 0.2 1.8 9.2 0.1 2.6 1 1 1 2 2 2 0 Exosome component EXOSC1/CSL4 Prok-RING_1 PF14446.6 AIF85238.1 - 0.037 14.0 0.7 0.058 13.3 0.7 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DNA_RNApol_7kD PF03604.13 AIF85238.1 - 0.57 9.9 2.3 1.5 8.6 2.3 1.6 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit PDT PF00800.18 AIF85239.1 - 9.7e-66 221.1 0.0 1.4e-65 220.5 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 AIF85239.1 - 4.8e-10 39.0 0.0 1.1e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 ACT domain DUF2526 PF10735.9 AIF85239.1 - 0.064 13.4 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2526) CPSase_sm_chain PF00988.22 AIF85239.1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase small chain, CPSase domain EMP24_GP25L PF01105.24 AIF85240.1 - 0.00021 21.3 0.0 0.00024 21.1 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SAYSvFN PF10260.9 AIF85240.1 - 0.032 14.1 1.0 1.1 9.3 0.3 2.3 2 0 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) PPC PF04151.15 AIF85240.1 - 0.043 14.9 0.3 0.08 14.1 0.3 1.5 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain DUF1533 PF07550.11 AIF85240.1 - 0.065 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) FixH PF05751.11 AIF85240.1 - 0.066 13.2 0.9 0.26 11.3 0.0 2.3 1 1 1 2 2 2 0 FixH DUF4198 PF10670.9 AIF85240.1 - 0.083 13.2 0.0 0.099 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) IMPDH PF00478.25 AIF85241.1 - 1.7e-148 494.3 7.8 1.9e-148 494.1 7.8 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 AIF85241.1 - 6.9e-25 87.3 0.3 3.1e-12 46.7 0.1 3.2 3 0 0 3 3 2 2 CBS domain NMO PF03060.15 AIF85241.1 - 8.3e-15 55.0 5.5 3.3e-11 43.2 2.0 2.3 2 1 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 AIF85241.1 - 9.5e-08 31.4 13.6 6.1e-07 28.8 13.4 2.4 2 1 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 AIF85241.1 - 8e-07 28.7 2.8 0.00041 19.9 0.1 2.8 2 1 1 3 3 3 2 Histidine biosynthesis protein DHO_dh PF01180.21 AIF85241.1 - 0.00035 19.9 3.8 0.0007 18.9 0.5 2.3 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase PEP_mutase PF13714.6 AIF85241.1 - 0.00035 20.1 1.4 0.037 13.5 0.2 2.4 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Radical_SAM PF04055.21 AIF85241.1 - 0.0096 16.3 0.1 4.3 7.7 0.0 3.0 2 1 1 3 3 3 1 Radical SAM superfamily Glu_synthase PF01645.17 AIF85241.1 - 0.011 14.8 3.4 0.022 13.9 3.4 1.4 1 0 0 1 1 1 0 Conserved region in glutamate synthase Dus PF01207.17 AIF85241.1 - 0.056 12.5 0.7 0.2 10.7 0.1 2.1 2 1 1 3 3 3 0 Dihydrouridine synthase (Dus) IGPS PF00218.21 AIF85241.1 - 0.068 12.3 0.0 13 4.8 0.0 2.5 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase ThiG PF05690.14 AIF85241.1 - 0.082 12.2 3.1 0.091 12.1 0.5 2.2 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG DUF561 PF04481.12 AIF85241.1 - 0.087 12.0 2.8 4.5 6.4 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF561) PucR PF07905.11 AIF85241.1 - 0.096 13.0 0.1 1.8 8.9 0.0 2.7 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family G3P_antiterm PF04309.12 AIF85241.1 - 0.52 9.7 5.0 0.98 8.8 0.1 3.4 4 0 0 4 4 4 0 Glycerol-3-phosphate responsive antiterminator Pterin_bind PF00809.22 AIF85242.1 - 3.7e-51 174.2 2.1 1.6e-50 172.1 2.1 1.8 1 1 0 1 1 1 1 Pterin binding enzyme ADH_zinc_N PF00107.26 AIF85244.1 - 2.3e-31 108.5 2.7 4e-31 107.7 2.7 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AIF85244.1 - 2.5e-23 83.6 0.2 4.1e-23 82.9 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AIF85244.1 - 4.3e-22 78.1 4.1 7.3e-22 77.3 4.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain NADH_4Fe-4S PF10589.9 AIF85244.1 - 0.02 15.0 0.8 0.043 13.9 0.8 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Eno-Rase_NADH_b PF12242.8 AIF85244.1 - 0.067 13.0 2.6 0.097 12.5 1.1 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF5012 PF16404.5 AIF85244.1 - 0.15 12.2 0.0 4.2 7.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5012) tRNA-synt_1 PF00133.22 AIF85245.1 - 6.2e-113 378.1 0.0 1.3e-111 373.7 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AIF85245.1 - 1.5e-32 112.7 0.3 3.7e-32 111.4 0.3 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AIF85245.1 - 3.9e-25 88.4 0.2 1.3e-13 50.5 0.0 3.4 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 AIF85245.1 - 0.00021 20.8 0.0 0.086 12.3 0.0 2.9 2 1 1 3 3 3 1 Leucyl-tRNA synthetase, Domain 2 DZR PF12773.7 AIF85245.1 - 0.0011 18.9 0.7 0.48 10.5 0.3 2.5 2 0 0 2 2 2 1 Double zinc ribbon tRNA-synt_1f PF01921.18 AIF85245.1 - 0.0062 15.5 0.0 1.1 8.0 0.0 3.1 3 0 0 3 3 3 1 tRNA synthetases class I (K) tRNA-synt_1e PF01406.19 AIF85245.1 - 0.017 14.5 0.0 0.2 11.0 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain TF_Zn_Ribbon PF08271.12 AIF85245.1 - 0.024 14.1 0.8 8.7 6.0 0.0 2.7 2 0 0 2 2 2 0 TFIIB zinc-binding zf-TFIIB PF13453.6 AIF85245.1 - 0.04 13.3 1.3 33 3.9 0.0 3.5 3 0 0 3 3 3 0 Transcription factor zinc-finger MqsA_antitoxin PF15731.5 AIF85245.1 - 0.087 12.9 0.0 1.8 8.6 0.0 2.5 2 0 0 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA zf-ribbon_3 PF13248.6 AIF85245.1 - 0.17 11.3 8.3 6.6 6.3 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain zf-ACC PF17848.1 AIF85245.1 - 1 9.5 6.3 47 4.2 0.6 3.6 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain Nudix_N_2 PF14803.6 AIF85245.1 - 1.8 8.6 4.1 11 6.0 0.0 2.9 2 1 0 2 2 2 0 Nudix N-terminal zinc_ribbon_2 PF13240.6 AIF85245.1 - 1.9 8.3 10.4 2.4 8.0 0.2 3.1 3 0 0 3 3 3 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 AIF85245.1 - 8 6.5 6.9 18 5.4 0.3 3.3 3 0 0 3 3 3 0 Transposase zinc-ribbon domain MAF_flag10 PF01973.18 AIF85246.1 - 2.9e-36 124.7 0.1 4.5e-36 124.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF115 TPK_catalytic PF04263.16 AIF85246.1 - 5.7e-05 23.2 0.2 0.00015 21.8 0.2 1.7 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain THF_DHG_CYH_C PF02882.19 AIF85246.1 - 0.1 11.9 0.6 0.15 11.4 0.6 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ac110_PIF PF07280.11 AIF85247.1 - 0.085 12.7 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Per os infectivity factor AC110 DUF945 PF06097.11 AIF85247.1 - 0.77 8.8 3.2 0.73 8.9 3.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) Mito_fiss_reg PF05308.11 AIF85248.1 - 0.00053 20.1 2.7 0.00073 19.7 2.7 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator YTH PF04146.15 AIF85248.1 - 0.1 12.5 0.1 0.12 12.3 0.1 1.2 1 1 0 1 1 1 0 YT521-B-like domain Glyco_transf_36 PF06165.11 AIF85248.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 36 GATase PF00117.28 AIF85249.1 - 2.9e-45 154.4 0.0 5e-45 153.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 AIF85249.1 - 9.7e-35 118.5 0.1 1.8e-34 117.6 0.1 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain NAD_synthase PF02540.17 AIF85249.1 - 1.5e-10 40.6 0.4 1.1e-05 24.7 0.0 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 AIF85249.1 - 2.4e-10 40.5 0.0 1.3e-09 38.1 0.0 2.3 2 0 0 2 2 2 1 Peptidase C26 ATP_bind_3 PF01171.20 AIF85249.1 - 1.5e-05 24.9 0.0 2.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 PP-loop family Asn_synthase PF00733.21 AIF85249.1 - 3.1e-05 23.8 0.0 5.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.13 AIF85249.1 - 5.2e-05 22.8 0.0 0.00091 18.8 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 AIF85249.1 - 0.00059 19.5 0.1 0.0052 16.4 0.0 2.1 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 AIF85249.1 - 0.0026 16.6 0.0 0.01 14.7 0.0 1.8 2 0 0 2 2 2 1 tRNA methyl transferase Methyltransf_25 PF13649.6 AIF85250.1 - 1e-18 67.8 0.0 8.3e-18 64.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIF85250.1 - 1.9e-18 66.7 0.0 2.9e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF85250.1 - 2.2e-17 63.2 0.0 6.2e-17 61.7 0.0 1.7 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 AIF85250.1 - 6.9e-16 58.7 0.0 9.5e-15 55.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF85250.1 - 4e-11 43.0 0.0 5.9e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF85250.1 - 3.7e-10 40.4 0.0 7.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AIF85250.1 - 8.9e-08 31.7 0.0 1.3e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 AIF85250.1 - 1.2e-07 31.7 0.0 1.6e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 AIF85250.1 - 0.00011 22.0 0.0 0.00022 21.0 0.0 1.5 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.14 AIF85250.1 - 0.00031 20.3 0.0 0.0005 19.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 AIF85250.1 - 0.00035 20.6 0.0 0.00048 20.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 AIF85250.1 - 0.00041 19.6 0.1 0.00084 18.6 0.1 1.4 1 1 0 1 1 1 1 O-methyltransferase Met_10 PF02475.16 AIF85250.1 - 0.0012 18.6 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_20 PF12147.8 AIF85250.1 - 0.002 17.4 0.0 0.0026 17.0 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 AIF85250.1 - 0.002 17.4 0.0 0.0033 16.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain GCD14 PF08704.10 AIF85250.1 - 0.0041 16.8 0.0 0.025 14.3 0.0 1.9 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit GidB PF02527.15 AIF85250.1 - 0.0091 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_18 PF12847.7 AIF85250.1 - 0.017 15.1 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CheR PF01739.18 AIF85250.1 - 0.032 13.7 0.0 2.1 7.8 0.0 2.3 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_15 PF09445.10 AIF85250.1 - 0.064 12.8 0.0 0.089 12.4 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase RrnaAD PF00398.20 AIF85250.1 - 0.099 11.7 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltr_RsmB-F PF01189.17 AIF85250.1 - 0.17 11.5 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F zf-C2H2 PF00096.26 AIF85251.1 - 5.5e-05 23.4 2.8 0.00011 22.5 2.8 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF85251.1 - 0.0018 19.0 3.0 0.0018 19.0 3.0 1.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf_UBZ PF18439.1 AIF85251.1 - 0.065 12.8 0.7 0.091 12.4 0.7 1.3 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-Mss51 PF13824.6 AIF85251.1 - 0.081 13.0 0.3 0.15 12.2 0.3 1.4 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C2H2_6 PF13912.6 AIF85251.1 - 0.097 12.7 3.2 0.16 12.0 3.2 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 AIF85251.1 - 0.1 12.4 0.4 0.1 12.4 0.4 1.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 AIF85251.1 - 1.6 9.3 7.5 12 6.5 0.6 2.3 2 0 0 2 2 2 0 Zinc-finger double domain MEDS PF14417.6 AIF85252.1 - 0.00016 21.6 0.1 0.00026 20.8 0.1 1.4 1 1 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Nitroreductase PF00881.24 AIF85254.1 - 9.1e-22 77.9 0.1 3.2e-10 40.3 0.0 2.1 1 1 1 2 2 2 2 Nitroreductase family TM1586_NiRdase PF14512.6 AIF85254.1 - 6.1e-05 22.7 0.0 0.24 10.9 0.0 2.2 2 0 0 2 2 2 2 Putative TM nitroreductase RNA_pol_A_CTD PF03118.15 AIF85257.1 - 0.00061 19.5 0.1 0.0008 19.1 0.1 1.2 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain HHH_5 PF14520.6 AIF85257.1 - 0.00068 20.2 0.6 0.00093 19.8 0.6 1.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.23 AIF85257.1 - 0.062 13.2 0.0 0.35 10.8 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif DUF4131 PF13567.6 AIF85258.1 - 1.2 8.8 6.3 3.9 7.1 4.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Wzy_C PF04932.15 AIF85258.1 - 5.1 6.7 10.2 4.7 6.8 6.3 2.0 1 1 1 2 2 2 0 O-Antigen ligase Asp_protease_2 PF13650.6 AIF85259.1 - 0.15 12.8 0.0 0.28 11.9 0.0 1.6 1 1 0 1 1 1 0 Aspartyl protease Copper-bind PF00127.20 AIF85261.1 - 2.7e-08 34.2 0.3 0.0021 18.5 0.1 2.4 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF85261.1 - 0.0001 22.3 1.3 0.065 13.4 0.1 3.1 1 1 1 2 2 2 2 Cupredoxin-like domain TBCA PF02970.16 AIF85263.1 - 0.066 13.5 0.2 0.083 13.2 0.2 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor A MerR-DNA-bind PF09278.11 AIF85263.1 - 0.085 13.4 0.5 2 9.0 0.5 2.3 1 1 0 1 1 1 0 MerR, DNA binding NPM1-C PF16276.5 AIF85263.1 - 0.51 10.4 2.7 0.63 10.1 0.9 2.3 2 1 0 2 2 2 0 Nucleophosmin C-terminal domain FtsX_ECD PF18075.1 AIF85267.1 - 0.077 13.6 0.1 0.15 12.7 0.1 1.4 1 0 0 1 1 1 0 FtsX extracellular domain SAM35 PF10806.8 AIF85267.1 - 0.08 13.2 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex Fe_dep_repr_C PF02742.15 AIF85268.1 - 1.1e-19 70.3 0.4 1.8e-19 69.6 0.4 1.4 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain Fe_dep_repress PF01325.19 AIF85268.1 - 4.7e-13 49.1 0.9 9.2e-13 48.2 0.9 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_5 PF01022.20 AIF85268.1 - 0.00045 20.0 0.0 0.00098 18.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family IF2_N PF04760.15 AIF85268.1 - 0.00065 19.5 0.9 0.0018 18.1 0.2 1.9 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region MarR_2 PF12802.7 AIF85268.1 - 0.0014 18.5 0.0 0.0025 17.6 0.0 1.4 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.20 AIF85268.1 - 0.0017 18.6 0.2 0.003 17.9 0.2 1.3 1 0 0 1 1 1 1 Transcriptional regulator MarR PF01047.22 AIF85268.1 - 0.0022 17.9 0.0 0.0039 17.1 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_IclR PF09339.10 AIF85268.1 - 0.0063 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_27 PF13463.6 AIF85268.1 - 0.0066 16.9 0.0 0.012 16.0 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.19 AIF85268.1 - 0.0088 15.9 0.1 0.015 15.1 0.1 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 AIF85268.1 - 0.04 13.9 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain AAA_assoc_C PF09821.9 AIF85268.1 - 0.064 13.8 0.0 0.15 12.6 0.0 1.6 1 1 0 1 1 1 0 C-terminal AAA-associated domain HTH_45 PF14947.6 AIF85268.1 - 0.11 12.5 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix Ferritin PF00210.24 AIF85269.1 - 1.6e-20 73.5 3.6 1.9e-20 73.2 3.6 1.0 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 AIF85269.1 - 1.1e-05 25.8 2.8 1.5e-05 25.4 2.8 1.3 1 0 0 1 1 1 1 Rubrerythrin Ferritin_2 PF13668.6 AIF85269.1 - 0.00019 21.6 0.5 0.00024 21.3 0.5 1.1 1 0 0 1 1 1 1 Ferritin-like domain Get5_C PF18514.1 AIF85269.1 - 0.32 10.7 1.2 0.65 9.8 0.5 1.8 2 0 0 2 2 2 0 Get5 C-terminal domain zinc_ribbon_2 PF13240.6 AIF85270.1 - 0.00029 20.4 1.1 0.14 12.0 0.1 2.2 2 0 0 2 2 2 2 zinc-ribbon domain Cript PF10235.9 AIF85270.1 - 0.0018 18.8 2.1 0.0021 18.6 2.1 1.2 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT DZR PF12773.7 AIF85270.1 - 0.003 17.5 2.6 0.0065 16.5 2.6 1.6 1 1 0 1 1 1 1 Double zinc ribbon Nudix_N_2 PF14803.6 AIF85270.1 - 0.0072 16.2 0.9 0.53 10.2 0.2 2.2 2 0 0 2 2 2 1 Nudix N-terminal zf-ribbon_3 PF13248.6 AIF85270.1 - 0.0091 15.4 0.5 0.64 9.5 0.0 2.2 2 0 0 2 2 2 1 zinc-ribbon domain DiS_P_DiS PF06750.13 AIF85270.1 - 0.016 15.4 0.2 1.4 9.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain Zn_ribbon_SprT PF17283.2 AIF85270.1 - 0.021 14.7 0.7 1.8 8.5 0.0 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zinc_ribbon_15 PF17032.5 AIF85270.1 - 0.026 15.3 1.1 0.035 14.9 1.1 1.2 1 0 0 1 1 1 0 zinc-ribbon family TackOD1 PF18551.1 AIF85270.1 - 0.036 13.7 0.3 0.051 13.3 0.3 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Med27 PF11571.8 AIF85270.1 - 0.053 13.9 0.6 1.5 9.3 0.0 2.0 2 0 0 2 2 2 0 Mediator complex subunit 27 HypA PF01155.19 AIF85270.1 - 0.15 12.0 1.4 0.35 10.9 1.4 1.6 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF4032 PF13224.6 AIF85271.1 - 0.0017 18.3 0.5 0.0018 18.2 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4032) Lactamase_B PF00753.27 AIF85273.1 - 4.1e-08 33.5 0.0 7e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AIF85273.1 - 5.5e-07 29.3 0.0 1e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Dis3l2_C_term PF17877.1 AIF85273.1 - 0.16 12.3 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal AAA_26 PF13500.6 AIF85274.1 - 1e-05 25.4 0.2 3.6e-05 23.7 0.2 1.8 1 1 0 1 1 1 1 AAA domain DUF1611 PF07755.11 AIF85274.1 - 1.4e-05 24.5 1.4 5e-05 22.7 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1611_C) P-loop domain CbiA PF01656.23 AIF85274.1 - 0.00049 20.1 0.1 0.001 19.2 0.1 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 AIF85274.1 - 0.0031 17.4 0.0 0.0081 16.1 0.0 1.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B CobA_CobO_BtuR PF02572.15 AIF85274.1 - 0.014 15.6 0.3 0.041 14.2 0.1 1.8 2 0 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Alk_phosphatase PF00245.20 AIF85274.1 - 0.018 14.0 0.0 0.028 13.4 0.0 1.3 1 0 0 1 1 1 0 Alkaline phosphatase ABC_tran PF00005.27 AIF85275.1 - 2.7e-34 118.6 1.0 4e-34 118.1 0.0 1.8 2 0 0 2 2 1 1 ABC transporter ABC_membrane PF00664.23 AIF85275.1 - 1.9e-29 103.2 6.6 2.7e-29 102.7 6.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 AIF85275.1 - 1.2e-07 31.4 0.8 0.00069 19.1 0.0 2.9 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 AIF85275.1 - 4.1e-06 26.8 0.2 0.0013 18.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AIF85275.1 - 0.00037 20.2 0.0 0.00093 18.9 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 AIF85275.1 - 0.00056 19.7 0.4 0.0021 17.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AIF85275.1 - 0.001 19.3 0.8 0.01 16.1 0.2 2.7 2 1 0 2 2 1 1 AAA domain AAA_23 PF13476.6 AIF85275.1 - 0.004 17.7 0.0 0.021 15.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AIF85275.1 - 0.0044 17.4 0.5 0.02 15.3 0.3 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 AIF85275.1 - 0.005 16.6 0.0 0.017 14.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain DUF87 PF01935.17 AIF85275.1 - 0.0058 16.8 1.6 0.028 14.5 0.1 2.5 2 1 0 2 2 2 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 AIF85275.1 - 0.03 14.2 0.0 0.09 12.7 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase G-alpha PF00503.20 AIF85275.1 - 0.036 13.2 0.1 0.083 12.0 0.0 1.6 2 0 0 2 2 2 0 G-protein alpha subunit DUF3987 PF13148.6 AIF85275.1 - 0.038 13.0 0.0 0.065 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) AAA_25 PF13481.6 AIF85275.1 - 0.048 13.2 0.0 0.14 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 AIF85275.1 - 0.05 12.4 1.1 1 8.1 0.0 3.0 3 1 0 3 3 3 0 Predicted ATPase of the ABC class AAA_33 PF13671.6 AIF85275.1 - 0.11 12.7 0.1 0.31 11.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain MMR_HSR1 PF01926.23 AIF85275.1 - 0.11 12.6 0.0 0.33 11.0 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 AIF85275.1 - 0.11 11.7 0.5 0.26 10.5 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin ATP_bind_1 PF03029.17 AIF85275.1 - 0.15 11.8 0.3 7.7 6.2 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Peptidase_M14 PF00246.24 AIF85276.1 - 2.7e-12 47.1 0.1 2.9e-11 43.7 0.1 2.1 1 1 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 AIF85276.1 - 0.00024 20.3 0.1 0.0004 19.6 0.1 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.8 AIF85276.1 - 0.0086 15.5 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) Polysacc_deac_1 PF01522.21 AIF85277.1 - 4.1e-09 36.4 0.0 8e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIF85277.1 - 4.3e-05 23.3 0.2 0.00017 21.3 0.2 1.9 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) SGBP_B_XBD PF18329.1 AIF85277.1 - 0.14 12.1 1.1 0.29 11.0 0.4 2.0 2 1 0 2 2 2 0 Surface glycan-binding protein B xyloglucan binding domain DUF4179 PF13786.6 AIF85278.1 - 0.1 13.1 0.5 0.17 12.4 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) ETRAMP PF09716.10 AIF85278.1 - 0.15 12.2 1.2 0.31 11.1 1.2 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF4367 PF14285.6 AIF85279.1 - 0.03 14.8 4.5 0.069 13.6 0.7 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4367) DUF4307 PF14155.6 AIF85279.1 - 0.21 11.4 0.9 0.98 9.3 0.7 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) DUF2267 PF10025.9 AIF85280.1 - 4.6e-07 30.1 0.1 5.4e-07 29.9 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2267) Bac_DNA_binding PF00216.21 AIF85280.1 - 0.00068 19.8 1.3 0.0094 16.1 0.1 2.2 2 0 0 2 2 2 1 Bacterial DNA-binding protein SLM4 PF16818.5 AIF85280.1 - 0.029 14.3 1.0 0.031 14.2 1.0 1.1 1 0 0 1 1 1 0 Protein SLM4 KI67R PF08065.12 AIF85280.1 - 0.033 14.7 3.0 0.044 14.3 3.0 1.1 1 0 0 1 1 1 0 KI67R (NUC007) repeat Tam41_Mmp37 PF09139.11 AIF85280.1 - 0.06 12.8 1.2 0.069 12.6 1.2 1.1 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial DUF937 PF06078.11 AIF85280.1 - 0.1 13.2 3.6 0.2 12.3 3.6 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF937) HMG_CoA_synt_C PF08540.10 AIF85280.1 - 0.13 11.9 0.9 0.56 9.8 0.0 1.9 1 1 1 2 2 2 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal PepSY PF03413.19 AIF85281.1 - 6e-05 23.5 0.3 0.00014 22.4 0.3 1.6 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain EVI2A PF05399.11 AIF85281.1 - 0.03 13.9 9.8 0.046 13.3 9.8 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Presenilin PF01080.17 AIF85281.1 - 0.054 12.3 1.4 0.069 11.9 1.4 1.3 1 0 0 1 1 1 0 Presenilin PA26 PF04636.13 AIF85281.1 - 0.34 9.8 0.9 0.44 9.4 0.9 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Hid1 PF12722.7 AIF85281.1 - 0.9 7.6 3.6 1.1 7.3 3.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.9 AIF85281.1 - 5 5.6 5.5 6.2 5.3 5.5 1.1 1 0 0 1 1 1 0 Macoilin family ApoLp-III PF07464.11 AIF85282.1 - 0.0066 16.5 4.9 0.0066 16.5 4.9 1.8 2 0 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) Laminin_II PF06009.12 AIF85282.1 - 0.0072 16.4 5.7 0.087 12.8 1.6 2.2 2 0 0 2 2 2 1 Laminin Domain II Mt_ATP-synt_D PF05873.12 AIF85282.1 - 0.0075 16.1 2.5 0.014 15.2 2.5 1.6 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) EspB PF05802.11 AIF85282.1 - 0.011 15.8 9.3 0.16 11.9 1.6 2.2 1 1 1 2 2 2 0 Enterobacterial EspB protein GT-D PF08759.11 AIF85282.1 - 0.024 14.3 1.2 0.024 14.3 1.2 1.4 2 0 0 2 2 2 0 Glycosyltransferase GT-D fold DUF4633 PF15464.6 AIF85282.1 - 0.034 14.3 1.5 0.034 14.3 1.5 2.2 2 1 1 3 3 2 0 Domain of unknown function (DUF4633) Apolipoprotein PF01442.18 AIF85282.1 - 0.039 13.8 11.8 0.083 12.8 5.7 2.1 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Atg14 PF10186.9 AIF85282.1 - 0.069 12.2 3.4 0.082 12.0 3.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1484 PF07363.11 AIF85282.1 - 0.088 13.8 0.9 0.21 12.6 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1484) Prominin PF05478.11 AIF85282.1 - 0.15 9.9 3.7 0.22 9.4 3.7 1.2 1 0 0 1 1 1 0 Prominin DUF2201_N PF13203.6 AIF85282.1 - 0.2 11.2 7.1 0.081 12.5 4.2 1.7 1 1 1 2 2 2 0 Putative metallopeptidase domain DUF948 PF06103.11 AIF85282.1 - 0.29 11.4 5.4 1.1 9.6 1.1 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) AAA_13 PF13166.6 AIF85282.1 - 0.35 9.5 6.9 0.053 12.2 3.2 1.4 2 0 0 2 2 2 0 AAA domain HisKA_3 PF07730.13 AIF85282.1 - 0.36 11.4 8.8 3 8.4 1.6 3.3 2 1 1 3 3 3 0 Histidine kinase UPF0242 PF06785.11 AIF85282.1 - 0.41 10.7 9.9 0.19 11.8 7.7 1.7 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF883 PF05957.13 AIF85282.1 - 0.76 10.4 10.7 0.54 10.9 1.3 2.9 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF1664 PF07889.12 AIF85282.1 - 1.4 9.0 6.5 1.5 8.9 4.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1043 PF06295.12 AIF85282.1 - 1.6 8.8 10.7 0.099 12.7 1.9 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1043) Med9 PF07544.13 AIF85282.1 - 3.6 7.7 8.8 0.42 10.7 3.2 2.3 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Exonuc_VII_L PF02601.15 AIF85282.1 - 7.1 6.1 10.8 13 5.3 10.8 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit Mod_r PF07200.13 AIF85282.1 - 7.3 6.7 10.2 46 4.1 9.2 2.5 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Putative_PNPOx PF01243.20 AIF85284.1 - 1.1e-06 28.8 0.0 1.4e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase F420H2_quin_red PF04075.14 AIF85284.1 - 0.0021 18.2 0.0 0.0031 17.6 0.0 1.3 1 1 0 1 1 1 1 F420H(2)-dependent quinone reductase Pyridox_ox_2 PF12900.7 AIF85284.1 - 0.03 14.3 0.0 0.043 13.8 0.0 1.4 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Pox_P35 PF03213.14 AIF85285.1 - 0.015 14.5 0.0 0.018 14.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus P35 protein CofC PF01983.16 AIF85285.1 - 0.015 14.5 0.0 0.017 14.3 0.0 1.0 1 0 0 1 1 1 0 Guanylyl transferase CofC like ACT_7 PF13840.6 AIF85285.1 - 0.11 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 ACT domain zf-C2H2 PF00096.26 AIF85285.1 - 0.22 12.1 1.1 0.32 11.5 1.1 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type YodL PF14191.6 AIF85286.1 - 0.11 13.4 0.0 0.14 13.0 0.0 1.3 1 0 0 1 1 1 0 YodL-like Kunitz_legume PF00197.18 AIF85287.1 - 0.068 13.1 0.0 0.071 13.0 0.0 1.1 1 0 0 1 1 1 0 Trypsin and protease inhibitor YSIRK_signal PF04650.17 AIF85289.1 - 0.26 11.2 1.7 0.8 9.6 1.7 1.9 1 0 0 1 1 1 0 YSIRK type signal peptide Cation_efflux PF01545.21 AIF85290.1 - 9.1e-48 162.6 5.3 1.2e-47 162.2 5.3 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 AIF85290.1 - 0.005 16.9 0.5 0.011 15.9 0.5 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF3098 PF11297.8 AIF85290.1 - 0.63 9.7 4.2 1.3 8.7 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3098) DUF1206 PF06724.11 AIF85290.1 - 0.67 10.1 0.1 0.67 10.1 0.1 4.1 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1206) TrbC PF04956.13 AIF85291.1 - 0.018 15.3 2.3 0.021 15.0 2.3 1.2 1 0 0 1 1 1 0 TrbC/VIRB2 family Myc_target_1 PF15179.6 AIF85291.1 - 0.41 10.5 1.4 0.47 10.3 1.4 1.2 1 0 0 1 1 1 0 Myc target protein 1 N6_N4_Mtase PF01555.18 AIF85292.1 - 3.2e-40 138.3 0.0 3.9e-40 138.0 0.0 1.0 1 0 0 1 1 1 1 DNA methylase Methyltransf_31 PF13847.6 AIF85293.1 - 4.4e-14 52.5 0.1 6e-14 52.1 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF85293.1 - 1.8e-11 44.6 0.3 3.9e-11 43.5 0.1 1.6 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 AIF85293.1 - 2e-09 37.2 0.2 7.5e-09 35.4 0.2 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 AIF85293.1 - 6.2e-09 36.4 0.2 1.4e-08 35.3 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 AIF85293.1 - 6.8e-09 35.5 0.5 8.5e-09 35.2 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 AIF85293.1 - 3.4e-08 34.1 0.0 6.4e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AIF85293.1 - 4.8e-08 33.0 0.2 5.8e-08 32.7 0.2 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 AIF85293.1 - 1.5e-07 31.5 0.2 2.1e-07 31.0 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AIF85293.1 - 7.2e-07 28.8 0.1 1e-06 28.3 0.1 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 AIF85293.1 - 3.4e-06 28.0 0.0 5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 AIF85293.1 - 1.5e-05 24.8 0.0 2.2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Ubie_methyltran PF01209.18 AIF85293.1 - 1.8e-05 24.2 0.3 2.3e-05 23.8 0.3 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_5 PF01795.19 AIF85293.1 - 4.5e-05 23.1 0.0 0.00053 19.6 0.0 2.0 1 1 1 2 2 2 1 MraW methylase family Cons_hypoth95 PF03602.15 AIF85293.1 - 0.00017 21.3 0.0 0.00021 21.0 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 AIF85293.1 - 0.00021 21.2 0.0 0.00042 20.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 AIF85293.1 - 0.00023 21.0 0.0 0.00032 20.5 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.10 AIF85293.1 - 0.00094 18.8 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltr_RsmB-F PF01189.17 AIF85293.1 - 0.0017 18.0 0.0 0.046 13.4 0.0 2.1 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F AviRa PF11599.8 AIF85293.1 - 0.002 17.6 0.0 0.0031 17.0 0.0 1.3 1 0 0 1 1 1 1 RRNA methyltransferase AviRa Methyltransf_3 PF01596.17 AIF85293.1 - 0.0021 17.3 0.1 0.0039 16.4 0.1 1.4 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_32 PF13679.6 AIF85293.1 - 0.0024 17.9 0.0 0.0036 17.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 AIF85293.1 - 0.0028 17.4 0.7 0.085 12.5 0.7 2.5 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 FmrO PF07091.11 AIF85293.1 - 0.0037 16.8 0.0 0.0073 15.9 0.0 1.5 1 1 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_4 PF02390.17 AIF85293.1 - 0.005 16.3 0.1 0.31 10.5 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Spermine_synth PF01564.17 AIF85293.1 - 0.011 15.2 0.2 0.017 14.5 0.2 1.5 1 1 0 1 1 1 0 Spermine/spermidine synthase domain rRNA_methylase PF06962.12 AIF85293.1 - 0.023 14.6 0.0 1.2 9.1 0.0 2.3 1 1 1 2 2 2 0 Putative rRNA methylase NodS PF05401.11 AIF85293.1 - 0.025 14.2 0.2 0.061 12.9 0.0 1.7 2 0 0 2 2 2 0 Nodulation protein S (NodS) TrmK PF04816.12 AIF85293.1 - 0.025 14.1 0.3 0.038 13.5 0.3 1.3 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase DOT1 PF08123.13 AIF85293.1 - 0.03 13.8 0.1 0.17 11.4 0.0 1.9 2 0 0 2 2 2 0 Histone methylation protein DOT1 RrnaAD PF00398.20 AIF85293.1 - 0.037 13.1 0.0 0.055 12.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase NNMT_PNMT_TEMT PF01234.17 AIF85293.1 - 0.039 13.1 0.1 0.48 9.6 0.0 2.1 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family POR PF01558.18 AIF85293.1 - 0.063 13.3 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase MetW PF07021.12 AIF85293.1 - 0.074 12.6 0.2 0.1 12.1 0.2 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW GidB PF02527.15 AIF85293.1 - 0.091 12.1 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G FtsJ PF01728.19 AIF85293.1 - 0.1 12.7 0.0 2.2 8.4 0.0 2.1 2 0 0 2 2 2 0 FtsJ-like methyltransferase DUF5518 PF17647.1 AIF85294.1 - 0.0021 18.2 8.8 0.0026 17.9 8.8 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5518) DUF1282 PF06930.12 AIF85294.1 - 0.044 13.6 3.0 0.062 13.1 3.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) Cytochrom_B558a PF05038.13 AIF85294.1 - 0.062 12.9 0.1 0.079 12.5 0.1 1.1 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit NnrS PF05940.12 AIF85294.1 - 0.079 12.3 4.2 0.11 11.9 4.2 1.3 1 1 0 1 1 1 0 NnrS protein Tail_VII PF17091.5 AIF85294.1 - 0.13 12.1 6.1 0.28 11.1 1.0 3.4 3 1 0 3 3 3 0 Inovirus G7P protein Glycophorin_A PF01102.18 AIF85294.1 - 0.14 12.4 0.8 0.41 10.9 0.0 1.9 2 0 0 2 2 2 0 Glycophorin A RseC_MucC PF04246.12 AIF85294.1 - 1.7 8.6 6.3 0.33 10.9 1.7 1.8 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF202 PF02656.15 AIF85294.1 - 3.2 8.2 5.3 3.8 8.0 0.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF3682 PF12446.8 AIF85297.1 - 0.0049 17.3 1.6 0.0081 16.6 1.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3682) DUF3385 PF11865.8 AIF85297.1 - 0.049 13.5 0.3 0.068 13.1 0.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3385) BsuBI_PstI_RE PF06616.11 AIF85299.1 - 0.023 14.0 0.0 0.96 8.7 0.0 2.1 2 0 0 2 2 2 0 BsuBI/PstI restriction endonuclease domain HSDR_N_2 PF13588.6 AIF85299.1 - 0.035 14.1 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Acatn PF13000.7 AIF85299.1 - 0.1 11.1 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 DUF2597 PF10772.9 AIF85300.1 - 0.06 13.4 0.1 0.18 11.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2597) vATP-synt_AC39 PF01992.16 AIF85301.1 - 8.4e-54 183.3 4.5 9.5e-54 183.1 4.5 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit CompInhib_SCIN PF11546.8 AIF85301.1 - 0.032 14.3 0.6 0.81 9.8 0.0 2.7 2 1 1 3 3 3 0 Staphylococcal complement inhibitor SCIN RTX_C PF08339.10 AIF85301.1 - 0.052 13.6 0.2 3.6 7.6 0.1 2.3 2 0 0 2 2 2 0 RTX C-terminal domain PP1_inhibitor PF05361.12 AIF85301.1 - 0.057 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor Zn_ribbon_2 PF12674.7 AIF85302.1 - 4.2e-23 81.8 0.1 4.8e-23 81.6 0.1 1.0 1 0 0 1 1 1 1 Putative zinc ribbon domain V_ATPase_I PF01496.19 AIF85303.1 - 4.8e-22 77.7 0.3 9.8e-18 63.5 0.0 3.0 3 1 0 3 3 3 2 V-type ATPase 116kDa subunit family PilN PF05137.13 AIF85303.1 - 0.0037 17.4 0.0 0.0077 16.3 0.0 1.5 1 0 0 1 1 1 1 Fimbrial assembly protein (PilN) Dynamitin PF04912.14 AIF85303.1 - 0.058 12.7 2.5 0.086 12.2 2.5 1.1 1 0 0 1 1 1 0 Dynamitin FlaC_arch PF05377.11 AIF85303.1 - 0.12 12.8 0.6 0.41 11.1 0.6 1.9 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF1192 PF06698.11 AIF85303.1 - 0.39 10.8 3.4 0.6 10.2 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) ATP-synt_C PF00137.21 AIF85304.1 - 2.5e-16 59.7 17.8 2.5e-16 59.7 17.8 2.1 2 0 0 2 2 2 1 ATP synthase subunit C SepZ PF06066.11 AIF85304.1 - 0.1 12.8 7.4 0.18 12.0 6.9 1.7 1 1 1 2 2 2 0 SepZ DUF4064 PF13273.6 AIF85304.1 - 1.8 8.9 17.0 0.12 12.6 11.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF3958 PF13125.6 AIF85305.1 - 0.0058 16.8 1.6 0.0062 16.7 1.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3958) ATP-synt_D PF01813.17 AIF85306.1 - 2.1e-48 164.8 6.4 2.5e-48 164.5 6.4 1.0 1 0 0 1 1 1 1 ATP synthase subunit D RNA_binding PF01877.17 AIF85306.1 - 0.03 14.6 7.2 0.28 11.5 0.8 2.2 2 0 0 2 2 2 0 RNA binding Skp1_POZ PF03931.15 AIF85306.1 - 0.055 13.6 0.3 5.2 7.3 0.0 2.6 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain ATP-synt_ab PF00006.25 AIF85307.1 - 2e-68 230.2 0.0 3.1e-68 229.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 AIF85307.1 - 1.5e-07 31.9 0.7 3.8e-07 30.5 0.7 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 AIF85307.1 - 0.049 13.8 0.3 0.25 11.5 0.3 2.2 2 0 0 2 2 2 0 HAS barrel domain ATP-synt_ab PF00006.25 AIF85308.1 - 2e-92 308.7 0.0 2.6e-92 308.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 AIF85308.1 - 4.3e-41 139.6 0.0 7.5e-41 138.8 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 AIF85308.1 - 9.5e-15 54.9 1.1 2.6e-14 53.5 0.3 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain AAA_22 PF13401.6 AIF85308.1 - 0.047 14.0 0.0 0.095 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 AIF85308.1 - 0.23 11.2 0.4 3.6 7.3 0.1 2.3 2 0 0 2 2 2 0 AAA domain vATP-synt_E PF01991.18 AIF85309.1 - 1.1e-21 77.1 8.9 1.9e-21 76.4 7.9 1.7 1 1 1 2 2 2 1 ATP synthase (E/31 kDa) subunit DUF4407 PF14362.6 AIF85309.1 - 0.027 13.8 4.3 0.034 13.5 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5301 PF17225.3 AIF85309.1 - 0.062 13.7 2.2 0.063 13.7 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5300) V-ATPase_G_2 PF16999.5 AIF85309.1 - 0.4 11.1 9.7 0.43 11.0 8.1 2.0 2 1 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit APG6_N PF17675.1 AIF85309.1 - 1.8 9.1 8.5 2.5 8.6 5.9 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region YkyA PF10368.9 AIF85309.1 - 1.9 8.1 10.2 0.59 9.8 6.2 1.9 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein Mut7-C PF01927.16 AIF85310.1 - 4e-39 134.0 0.0 4.6e-39 133.9 0.0 1.0 1 0 0 1 1 1 1 Mut7-C RNAse domain DUF5615 PF18480.1 AIF85310.1 - 1.2e-09 37.8 0.0 1.9e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5615) PIN_10 PF18478.1 AIF85310.1 - 0.00093 19.4 0.0 0.0028 17.8 0.0 1.9 2 1 0 2 2 2 1 PIN like domain PIN_9 PF18477.1 AIF85310.1 - 0.0022 18.3 0.0 0.0036 17.6 0.0 1.3 1 0 0 1 1 1 1 PIN like domain Zn_ribbon_SprT PF17283.2 AIF85310.1 - 1.4 8.9 4.4 23 5.0 0.1 2.2 2 0 0 2 2 2 0 SprT-like zinc ribbon domain CBS PF00571.28 AIF85311.1 - 1e-21 77.1 4.4 1.2e-11 44.9 0.6 2.4 2 0 0 2 2 2 2 CBS domain DP-EP PF08985.11 AIF85311.1 - 0.048 13.8 0.4 0.084 13.1 0.4 1.3 1 0 0 1 1 1 0 DP-EP family TF_Zn_Ribbon PF08271.12 AIF85311.1 - 0.068 12.7 2.0 0.2 11.2 2.0 1.8 1 0 0 1 1 1 0 TFIIB zinc-binding Acetyltransf_8 PF13523.6 AIF85311.1 - 0.12 12.0 0.0 0.31 10.7 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Rubredoxin_2 PF18073.1 AIF85311.1 - 0.14 11.9 2.2 0.17 11.6 0.3 1.9 2 0 0 2 2 2 0 Rubredoxin metal binding domain FbpA PF05833.11 AIF85312.1 - 7.9e-31 107.3 2.0 1.1e-30 106.8 2.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 AIF85312.1 - 2.3e-23 82.9 0.0 6.5e-23 81.5 0.0 1.8 1 0 0 1 1 1 1 NFACT protein RNA binding domain H2TH PF06831.14 AIF85312.1 - 0.07 13.1 0.0 0.36 10.8 0.0 2.2 2 0 0 2 2 2 0 Formamidopyrimidine-DNA glycosylase H2TH domain baeRF_family2 PF18844.1 AIF85312.1 - 0.39 10.8 6.0 0.36 10.9 4.0 1.9 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 2 Trns_repr_metal PF02583.17 AIF85312.1 - 2.3 8.7 7.1 7.5 7.0 0.2 3.6 3 0 0 3 3 3 0 Metal-sensitive transcriptional repressor Lactamase_B_2 PF12706.7 AIF85314.1 - 4.3e-09 36.2 0.0 7e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AIF85314.1 - 0.047 13.6 0.0 0.32 10.9 0.0 2.2 2 1 1 3 3 3 0 Beta-lactamase superfamily domain CDC48_N PF02359.18 AIF85315.1 - 8.7e-24 83.5 1.5 8.7e-24 83.5 1.5 1.7 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain CDC48_2 PF02933.17 AIF85315.1 - 1.1e-10 41.1 0.1 4.1e-10 39.3 0.0 2.0 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 PUA PF01472.20 AIF85315.1 - 0.00079 19.3 0.5 11 6.1 0.0 4.1 2 1 2 4 4 4 2 PUA domain PyrI PF01948.18 AIF85318.1 - 3.9e-32 110.4 2.2 6.6e-32 109.6 2.2 1.4 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, allosteric domain PyrI_C PF02748.15 AIF85318.1 - 9.7e-17 60.6 1.5 1.7e-16 59.9 1.5 1.4 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain Saf_2TM PF18303.1 AIF85318.1 - 0.11 12.1 0.4 0.47 10.0 0.1 1.9 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain DZR PF12773.7 AIF85319.1 - 0.00049 20.1 6.2 0.0018 18.2 6.4 1.8 1 1 0 1 1 1 1 Double zinc ribbon Zn_ribbon_SprT PF17283.2 AIF85319.1 - 0.49 10.4 4.7 0.65 9.9 0.3 2.4 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-C2H2_4 PF13894.6 AIF85319.1 - 0.74 10.8 0.1 0.74 10.8 0.1 3.6 4 1 1 5 5 5 0 C2H2-type zinc finger Ribosomal_L37e PF01907.19 AIF85319.1 - 0.74 10.0 9.6 3 8.1 0.6 2.3 1 1 1 2 2 2 0 Ribosomal protein L37e NMD3 PF04981.13 AIF85319.1 - 0.97 8.8 7.2 2.2 7.7 1.5 2.2 2 0 0 2 2 2 0 NMD3 family zf-B_box PF00643.24 AIF85319.1 - 2.6 8.2 8.2 47 4.2 2.3 3.7 3 1 0 3 3 3 0 B-box zinc finger zinc_ribbon_9 PF14369.6 AIF85319.1 - 4.4 7.6 0.0 4.4 7.6 0.0 3.3 3 1 0 3 3 3 0 zinc-ribbon Zn-ribbon_8 PF09723.10 AIF85319.1 - 6 7.1 11.1 7.1 6.8 5.0 2.9 2 1 0 2 2 2 0 Zinc ribbon domain DUF2797 PF10977.8 AIF85319.1 - 6.3 6.6 8.2 0.97 9.3 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2797) XPA_N PF01286.18 AIF85319.1 - 6.3 6.9 11.0 0.93 9.6 1.6 3.4 3 1 0 3 3 3 0 XPA protein N-terminal Thioredoxin_10 PF17991.1 AIF85320.1 - 1.6e-35 122.8 0.0 2.7e-35 122.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin like C-terminal domain AhpC-TSA PF00578.21 AIF85320.1 - 1.2e-14 54.3 0.1 1.8e-14 53.7 0.1 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIF85320.1 - 4.3e-11 42.7 0.0 7.1e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 AIF85320.1 - 2.4e-08 34.2 0.2 4.7e-08 33.3 0.2 1.4 1 0 0 1 1 1 1 Thioredoxin-like GSHPx PF00255.19 AIF85320.1 - 0.00019 21.0 0.0 0.00039 20.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin PF00085.20 AIF85320.1 - 0.055 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin CD52 PF15116.6 AIF85320.1 - 6.7 6.8 7.0 5.2 7.2 0.7 2.3 2 0 0 2 2 2 0 CAMPATH-1 antigen DsbD PF02683.15 AIF85321.1 - 1.1e-47 162.8 18.0 6e-37 127.6 13.4 2.0 1 1 1 2 2 2 2 Cytochrome C biogenesis protein transmembrane region DsbD_2 PF13386.6 AIF85321.1 - 1.1e-06 28.7 16.0 1.8e-06 28.0 16.0 1.3 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region SfLAP PF11139.8 AIF85321.1 - 1.1 8.6 15.0 3.9 6.9 15.0 1.8 1 1 0 1 1 1 0 Sap, sulfolipid-1-addressing protein DUF3119 PF11317.8 AIF85321.1 - 2.1 8.6 7.8 0.37 11.1 0.9 2.6 2 2 0 2 2 2 0 Protein of unknown function (DUF3119) HTH_5 PF01022.20 AIF85323.1 - 7.4e-09 35.3 0.0 9.8e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family TrmB PF01978.19 AIF85323.1 - 0.00021 21.1 0.0 0.0003 20.6 0.0 1.1 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 AIF85323.1 - 0.0023 18.0 0.0 0.0032 17.5 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 AIF85323.1 - 0.0037 16.8 0.1 0.0068 15.9 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding FaeA PF04703.12 AIF85323.1 - 0.018 15.4 0.0 0.028 14.8 0.0 1.3 1 0 0 1 1 1 0 FaeA-like protein DprA_WH PF17782.1 AIF85323.1 - 0.019 15.1 0.0 0.028 14.6 0.0 1.3 1 0 0 1 1 1 0 DprA winged helix domain Phage_rep_O PF04492.13 AIF85323.1 - 0.02 15.4 0.0 0.028 15.0 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage replication protein O HTH_29 PF13551.6 AIF85323.1 - 0.028 14.4 0.0 0.042 13.9 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix HTH_45 PF14947.6 AIF85323.1 - 0.061 13.3 0.1 0.091 12.8 0.1 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix MarR PF01047.22 AIF85323.1 - 0.1 12.5 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 MarR family AAA_31 PF13614.6 AIF85324.1 - 8.4e-19 68.2 0.5 1.2e-17 64.4 0.5 2.1 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 AIF85324.1 - 2.7e-14 53.3 0.0 3.8e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 AIF85324.1 - 7.5e-14 51.8 0.0 1.4e-11 44.4 0.0 2.4 3 0 0 3 3 3 1 NUBPL iron-transfer P-loop NTPase MipZ PF09140.11 AIF85324.1 - 9.5e-09 34.9 0.0 8.5e-07 28.5 0.0 2.1 2 0 0 2 2 2 2 ATPase MipZ ArsA_ATPase PF02374.15 AIF85324.1 - 6.4e-05 22.3 0.0 0.00029 20.1 0.0 1.9 2 0 0 2 2 2 1 Anion-transporting ATPase VirC1 PF07015.11 AIF85324.1 - 0.00025 20.4 0.8 0.00033 20.0 0.1 1.5 2 0 0 2 2 2 1 VirC1 protein CBP_BcsQ PF06564.12 AIF85324.1 - 0.0013 18.3 0.0 0.015 14.8 0.0 2.0 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 AIF85324.1 - 0.0024 17.4 0.0 0.011 15.1 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 AIF85324.1 - 0.0029 17.3 0.2 0.011 15.4 0.1 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain CLP1_P PF16575.5 AIF85324.1 - 0.013 15.4 0.0 0.042 13.6 0.0 1.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop APS_kinase PF01583.20 AIF85324.1 - 0.08 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase ATPase PF06745.13 AIF85325.1 - 3.4e-26 92.0 0.0 6.3e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.6 AIF85325.1 - 2.1e-05 24.8 0.0 4.3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Guanylate_cyc PF00211.20 AIF85325.1 - 6.2e-05 22.7 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AAA_25 PF13481.6 AIF85325.1 - 0.00033 20.3 0.0 0.00094 18.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain MEDS PF14417.6 AIF85325.1 - 0.0012 18.7 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain AAA_14 PF13173.6 AIF85325.1 - 0.0031 17.5 0.0 0.007 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 AIF85325.1 - 0.0079 15.9 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein GvpD PF07088.11 AIF85325.1 - 0.01 14.5 0.0 0.065 11.8 0.0 1.9 1 1 0 1 1 1 0 GvpD gas vesicle protein AAA_16 PF13191.6 AIF85325.1 - 0.012 16.0 0.0 0.024 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 AIF85325.1 - 0.021 14.4 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 AIF85325.1 - 0.074 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 AIF85325.1 - 0.2 11.4 1.0 0.6 9.9 0.1 2.2 3 0 0 3 3 3 0 P-loop containing region of AAA domain DEAD PF00270.29 AIF85326.1 - 3.6e-53 179.9 0.4 7.8e-52 175.6 0.1 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AIF85326.1 - 5.2e-34 116.9 0.2 9.2e-32 109.7 0.2 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AIF85326.1 - 4e-07 30.2 0.0 1.2e-06 28.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 AIF85326.1 - 0.00033 20.6 0.1 0.0017 18.2 0.0 2.0 1 1 1 2 2 2 1 Helicase UTP25 PF06862.12 AIF85326.1 - 0.0013 17.6 0.0 0.074 11.8 0.0 2.7 2 1 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 AIF85326.1 - 0.0024 17.3 1.0 0.005 16.2 0.4 1.8 1 1 1 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Flavi_DEAD PF07652.14 AIF85326.1 - 0.0064 16.5 0.2 0.68 9.9 0.1 2.6 2 1 0 2 2 2 1 Flavivirus DEAD domain LuxC PF05893.14 AIF85326.1 - 0.011 14.8 0.1 0.37 9.8 0.0 2.1 1 1 1 2 2 2 0 Acyl-CoA reductase (LuxC) adh_short PF00106.25 AIF85326.1 - 0.023 14.2 0.2 0.06 12.8 0.2 1.7 1 0 0 1 1 1 0 short chain dehydrogenase CobA_CobO_BtuR PF02572.15 AIF85326.1 - 0.046 14.0 0.6 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Peptidase_M66 PF10462.9 AIF85326.1 - 0.09 11.7 0.0 0.09 11.7 0.0 2.7 2 1 1 3 3 1 0 Peptidase M66 zinc_ribbon_2 PF13240.6 AIF85327.1 - 2.2e-05 24.0 4.3 3.8e-05 23.3 4.3 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 AIF85327.1 - 0.00014 21.8 0.8 0.0002 21.3 0.8 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 AIF85327.1 - 0.0008 18.7 3.4 0.0012 18.1 3.4 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DUF2116 PF09889.9 AIF85327.1 - 0.0027 17.7 2.3 0.0057 16.6 2.3 1.6 1 0 0 1 1 1 1 Uncharacterized protein containing a Zn-ribbon (DUF2116) zinc_ribbon_15 PF17032.5 AIF85327.1 - 0.0032 18.2 0.2 0.0053 17.5 0.2 1.4 1 0 0 1 1 1 1 zinc-ribbon family CdvA PF18822.1 AIF85327.1 - 0.033 14.0 0.1 0.047 13.5 0.1 1.2 1 0 0 1 1 1 0 CdvA-like coiled-coil domain UPF0547 PF10571.9 AIF85327.1 - 0.28 11.3 4.7 0.49 10.5 4.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 DHHC PF01529.20 AIF85327.1 - 0.37 10.9 1.6 0.76 9.9 0.7 1.7 2 0 0 2 2 2 0 DHHC palmitoyltransferase zinc_ribbon_2 PF13240.6 AIF85328.1 - 2.6e-06 27.0 4.0 4.4e-06 26.2 4.0 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 AIF85328.1 - 1.3e-05 25.1 0.8 2e-05 24.5 0.8 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 AIF85328.1 - 0.00039 19.7 2.4 0.00064 19.0 2.4 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 AIF85328.1 - 0.0014 19.3 0.1 0.0016 19.2 0.1 1.2 1 0 0 1 1 1 1 zinc-ribbon family UPF0547 PF10571.9 AIF85328.1 - 0.055 13.6 1.8 0.092 12.9 1.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Nudix_N_2 PF14803.6 AIF85328.1 - 0.059 13.3 6.3 1.4 8.9 0.2 2.4 2 0 0 2 2 2 0 Nudix N-terminal zf-C4H2 PF10146.9 AIF85328.1 - 0.14 12.4 0.1 0.15 12.4 0.1 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein RNA_POL_M_15KD PF02150.16 AIF85328.1 - 0.16 11.9 3.8 12 5.9 0.7 3.0 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit DHHC PF01529.20 AIF85328.1 - 0.17 12.0 0.3 0.24 11.5 0.3 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase NOB1_Zn_bind PF08772.11 AIF85328.1 - 2.3 8.4 6.4 33 4.8 6.6 2.5 2 1 1 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like Polyketide_cyc2 PF10604.9 AIF85329.1 - 1.1e-05 25.8 0.0 1.2e-05 25.7 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF2070 PF09843.9 AIF85330.1 - 1.4 7.1 13.2 1.8 6.7 13.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Fil_haemagg PF05594.14 AIF85330.1 - 2.7 8.6 16.3 3.8e+02 1.7 16.3 3.3 1 1 0 1 1 1 0 Haemagluttinin repeat DUF4234 PF14018.6 AIF85330.1 - 4.7 7.4 5.8 20 5.4 1.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4234) Spt4 PF06093.13 AIF85331.1 - 0.0057 16.7 1.6 0.0062 16.6 1.6 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger zf-RRN7 PF11781.8 AIF85331.1 - 0.036 13.7 1.6 1.7 8.4 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TF_Zn_Ribbon PF08271.12 AIF85331.1 - 0.058 12.9 3.7 2 8.0 3.8 2.0 1 1 0 1 1 1 0 TFIIB zinc-binding GATA PF00320.27 AIF85331.1 - 0.073 12.7 3.1 0.26 10.9 0.3 2.1 2 0 0 2 2 2 0 GATA zinc finger DUF35_N PF12172.8 AIF85331.1 - 0.18 11.7 3.1 0.35 10.8 3.1 1.6 1 1 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF983 PF06170.12 AIF85331.1 - 0.27 11.6 0.9 1.8 9.0 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF983) AAA_18 PF13238.6 AIF85332.1 - 3.4e-10 40.6 0.1 4.6e-10 40.1 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 AIF85332.1 - 3.1e-05 24.4 0.1 7.5e-05 23.2 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AIF85332.1 - 0.001 18.8 0.1 0.0016 18.2 0.1 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 AIF85332.1 - 0.0027 17.6 0.3 0.017 15.1 0.0 2.2 1 1 0 2 2 2 1 NTPase Cytidylate_kin2 PF13189.6 AIF85332.1 - 0.013 15.6 0.1 4.5 7.4 0.0 2.6 1 1 1 2 2 2 0 Cytidylate kinase-like family AAA_17 PF13207.6 AIF85332.1 - 0.015 15.7 1.4 0.03 14.8 0.6 1.9 1 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AIF85332.1 - 0.042 14.1 0.1 0.22 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 AIF85332.1 - 0.065 13.4 0.2 0.79 9.8 0.0 2.4 2 1 0 2 2 2 0 Shikimate kinase Rad17 PF03215.15 AIF85332.1 - 0.075 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain KTI12 PF08433.10 AIF85332.1 - 0.098 12.1 0.1 0.19 11.2 0.1 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF4177 PF13783.6 AIF85333.1 - 0.075 13.3 0.0 0.077 13.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4177) DUF1485 PF07364.12 AIF85333.1 - 0.11 11.7 0.0 0.12 11.7 0.0 1.0 1 0 0 1 1 1 0 Metallopeptidase family M81 Lsm_C PF14894.6 AIF85335.1 - 2.3e-20 72.1 0.3 2e-19 69.1 0.0 2.1 2 0 0 2 2 2 1 Lsm C-terminal LSM PF01423.22 AIF85335.1 - 9.9e-07 28.4 0.1 1.9e-06 27.4 0.1 1.5 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AIF85335.1 - 2.6e-05 24.2 0.1 4.4e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 AIF85335.1 - 4.2e-05 23.6 0.1 8.4e-05 22.6 0.1 1.5 1 1 0 1 1 1 1 Scd6-like Sm domain DUF150_C PF17384.2 AIF85335.1 - 0.0048 17.0 0.1 0.009 16.1 0.1 1.5 1 0 0 1 1 1 1 RimP C-terminal SH3 domain DUF2642 PF10842.8 AIF85335.1 - 0.15 12.0 0.1 0.31 10.9 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2642) TGT PF01702.18 AIF85336.1 - 1.6e-69 234.7 0.0 2.1e-69 234.3 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF5591 PF17884.1 AIF85336.1 - 1.2e-06 28.4 0.0 2.1e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5591) Endonuclease_5 PF04493.14 AIF85337.1 - 1.6e-50 171.6 0.0 1.9e-50 171.3 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V DUF99 PF01949.16 AIF85337.1 - 0.027 13.9 0.0 0.066 12.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF99 Fer4 PF00037.27 AIF85339.1 - 7.7e-13 47.7 10.8 1.2e-07 31.3 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 AIF85339.1 - 1.5e-09 37.5 8.9 0.00017 21.5 2.3 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 AIF85339.1 - 2.1e-09 37.8 3.9 2.9e-09 37.4 3.9 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIF85339.1 - 2.9e-08 33.7 1.6 4.2e-08 33.2 1.6 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIF85339.1 - 5.4e-07 29.3 9.1 0.0013 18.7 2.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 AIF85339.1 - 6e-07 29.9 5.0 0.0025 18.3 0.9 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_9 PF13187.6 AIF85339.1 - 1.3e-06 28.5 4.4 4.3e-06 26.8 4.6 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIF85339.1 - 1.3e-06 28.4 13.7 0.00021 21.3 8.2 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 AIF85339.1 - 1.6e-05 25.0 6.2 0.016 15.6 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 AIF85339.1 - 0.00021 22.1 5.6 0.11 13.4 0.1 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_15 PF13459.6 AIF85339.1 - 0.00043 21.0 10.9 0.0068 17.1 2.4 2.7 1 1 1 2 2 2 2 4Fe-4S single cluster domain Fer4_22 PF17179.4 AIF85339.1 - 0.0008 20.2 2.3 0.39 11.6 0.5 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIF85339.1 - 0.00091 19.6 6.2 0.0076 16.7 6.2 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIF85339.1 - 0.0017 19.1 13.4 0.27 12.3 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 AIF85339.1 - 0.0026 18.3 7.2 0.094 13.3 7.2 2.1 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_18 PF13746.6 AIF85339.1 - 0.21 11.8 10.9 1.7 8.9 1.0 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain P53_TAD PF08563.11 AIF85340.1 - 0.096 12.2 0.5 0.14 11.7 0.5 1.3 1 0 0 1 1 1 0 P53 transactivation motif Methyltransf_23 PF13489.6 AIF85341.1 - 0.061 13.2 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 AIF85341.1 - 0.18 11.4 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_31 PF13847.6 AIF85341.1 - 0.19 11.5 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 AIF85342.1 - 0.0086 15.7 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_31 PF13847.6 AIF85342.1 - 0.026 14.3 0.0 0.076 12.8 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 AIF85342.1 - 0.028 14.3 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain BNR_2 PF13088.6 AIF85343.1 - 0.00097 18.5 0.0 0.17 11.2 0.0 2.2 1 1 1 2 2 2 2 BNR repeat-like domain Parvo_coat_N PF08398.10 AIF85343.1 - 0.035 14.2 0.0 21 5.3 0.0 3.0 3 0 0 3 3 3 0 Parvovirus coat protein VP1 Lactamase_B_6 PF16661.5 AIF85345.1 - 3.4e-14 52.7 0.0 6.3e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 AIF85345.1 - 9.9e-14 51.6 0.0 2.3e-13 50.4 0.0 1.6 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 AIF85345.1 - 3.5e-11 42.9 0.0 1.6e-10 40.8 0.0 2.0 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 AIF85345.1 - 3.7e-09 36.9 0.1 1.1e-06 28.8 0.0 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AIF85345.1 - 1.1e-07 31.6 0.0 4.2e-07 29.7 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AIF85345.1 - 1e-05 25.5 0.0 3.3e-05 23.9 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain CsgE PF10627.9 AIF85345.1 - 0.2 11.9 0.0 0.59 10.4 0.0 1.7 2 0 0 2 2 2 0 Curli assembly protein CsgE zf-3CxxC_2 PF17180.4 AIF85346.1 - 0.49 11.2 4.5 4.6 8.1 4.5 2.0 1 1 0 1 1 1 0 Zinc-binding domain Bactofilin PF04519.13 AIF85347.1 - 0.026 14.8 7.8 0.16 12.3 5.5 2.1 1 1 1 2 2 2 0 Polymer-forming cytoskeletal tRNA-synt_1e PF01406.19 AIF85348.1 - 5.5e-128 426.6 0.5 7.8e-128 426.1 0.1 1.4 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 AIF85348.1 - 9.6e-15 54.2 1.3 1.4e-07 30.7 0.3 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AIF85348.1 - 6.2e-09 34.7 0.0 6.3e-06 24.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.11 AIF85348.1 - 3.5e-08 33.8 2.9 7.2e-08 32.8 1.6 2.3 2 0 0 2 2 2 1 DALR domain tRNA-synt_1f PF01921.18 AIF85348.1 - 3.7e-07 29.4 0.1 0.004 16.1 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (K) tRNA-synt_1c PF00749.21 AIF85348.1 - 0.0034 16.3 0.5 0.1 11.5 0.2 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain SOAR PF16533.5 AIF85348.1 - 0.35 10.9 2.1 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 STIM1 Orai1-activating region Rieske PF00355.26 AIF85349.1 - 1.5e-15 56.9 0.0 1.7e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIF85349.1 - 6.8e-12 45.2 0.0 7.5e-12 45.1 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain VIT1 PF01988.19 AIF85350.1 - 0.0051 16.7 1.7 0.13 12.1 0.4 2.1 2 0 0 2 2 2 2 VIT family ABC2_membrane_2 PF12679.7 AIF85350.1 - 0.075 12.3 1.2 0.17 11.1 1.2 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein T7SS_ESX1_EccB PF05108.13 AIF85350.1 - 0.077 11.6 0.4 0.12 11.0 0.4 1.4 1 0 0 1 1 1 0 Type VII secretion system ESX-1, transport TM domain B AdoHcyase PF05221.17 AIF85351.1 - 3.3e-53 180.8 0.0 1.9e-26 92.9 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 AIF85351.1 - 3.8e-51 173.4 0.1 8.4e-51 172.2 0.0 1.6 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIF85351.1 - 6.2e-10 38.7 0.0 1.5e-09 37.5 0.0 1.7 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 AIF85351.1 - 2.2e-05 24.1 0.0 0.00012 21.7 0.0 2.0 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 AIF85351.1 - 0.0001 21.7 4.7 0.0002 20.7 2.5 2.5 2 1 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 AIF85351.1 - 0.0045 17.2 0.1 0.015 15.6 0.1 1.9 1 0 0 1 1 1 1 TrkA-N domain PspA_IM30 PF04012.12 AIF85351.1 - 0.084 12.4 0.6 0.13 11.9 0.6 1.2 1 0 0 1 1 1 0 PspA/IM30 family tRNA-synt_1g PF09334.11 AIF85352.1 - 4.1e-136 453.8 0.1 5.3e-136 453.4 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AIF85352.1 - 7.4e-15 54.2 1.0 4.3e-06 25.3 0.0 3.8 2 2 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AIF85352.1 - 2e-14 53.8 0.1 3.2e-14 53.1 0.1 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 AIF85352.1 - 8.6e-11 41.7 0.1 0.00022 20.7 0.2 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 AIF85352.1 - 0.0034 16.3 0.0 0.14 11.0 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetases class I (K) DZR PF12773.7 AIF85352.1 - 0.77 9.8 5.2 1.4 9.0 5.2 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 AIF85352.1 - 3.3 7.3 8.8 15 5.1 2.2 2.4 1 1 1 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 AIF85352.1 - 4.1 7.0 6.6 0.75 9.4 2.5 1.9 1 1 1 2 2 2 0 TFIIB zinc-binding Lar_restr_allev PF14354.6 AIF85352.1 - 6.3 7.3 9.6 34 4.9 0.0 3.5 2 1 0 3 3 3 0 Restriction alleviation protein Lar CTP_transf_like PF01467.26 AIF85353.1 - 1.9e-14 54.0 0.0 2.9e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like HIGH_NTase1 PF05636.11 AIF85353.1 - 0.0016 17.8 0.0 0.027 13.7 0.0 2.0 2 0 0 2 2 2 1 HIGH Nucleotidyl Transferase ATP-sulfurylase PF01747.17 AIF85353.1 - 0.0076 15.7 0.1 0.65 9.4 0.0 2.3 2 1 0 2 2 2 2 ATP-sulfurylase Citrate_ly_lig PF08218.11 AIF85353.1 - 0.012 15.3 0.1 0.17 11.6 0.0 2.5 2 1 0 2 2 2 0 Citrate lyase ligase C-terminal domain Pantoate_ligase PF02569.15 AIF85353.1 - 0.18 11.0 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase zf-CSL PF05207.13 AIF85354.1 - 0.00058 19.5 1.6 0.00067 19.3 1.6 1.1 1 0 0 1 1 1 1 CSL zinc finger Zn_Tnp_IS1595 PF12760.7 AIF85354.1 - 0.0076 16.2 1.9 0.01 15.8 1.9 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zinc_ribbon_5 PF13719.6 AIF85354.1 - 0.011 15.4 1.8 0.017 14.9 1.8 1.4 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_4 PF13717.6 AIF85354.1 - 0.014 15.3 1.5 0.023 14.6 1.5 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Lar_restr_allev PF14354.6 AIF85354.1 - 0.021 15.2 1.5 0.028 14.8 1.5 1.2 1 0 0 1 1 1 0 Restriction alleviation protein Lar Elf1 PF05129.13 AIF85354.1 - 0.044 13.8 1.4 0.047 13.8 1.4 1.1 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DUF2072 PF09845.9 AIF85354.1 - 0.062 13.6 0.3 0.065 13.5 0.3 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein zf-H2C2 PF09337.10 AIF85354.1 - 0.085 13.1 1.2 0.35 11.1 0.1 2.0 2 0 0 2 2 2 0 H2C2 zinc finger Zn-ribbon_8 PF09723.10 AIF85354.1 - 1.2 9.3 6.3 1.4 9.1 1.3 2.2 1 1 1 2 2 2 0 Zinc ribbon domain MS_channel PF00924.18 AIF85355.1 - 1.1e-07 31.7 1.4 3.3e-07 30.1 1.4 1.7 1 1 0 1 1 1 1 Mechanosensitive ion channel Rib PF08428.10 AIF85356.1 - 0.087 12.8 0.1 0.25 11.4 0.1 1.8 1 0 0 1 1 1 0 Rib/alpha-like repeat Pirin PF02678.16 AIF85357.1 - 5.1e-35 119.7 0.8 9.4e-35 118.9 0.8 1.4 1 0 0 1 1 1 1 Pirin Pirin_C_2 PF17954.1 AIF85357.1 - 4.5e-23 81.2 0.7 1.2e-22 79.9 0.3 1.9 2 0 0 2 2 2 1 Quercetinase C-terminal cupin domain Pirin_C PF05726.13 AIF85357.1 - 1.2e-06 28.8 0.1 8.6e-05 22.8 0.0 2.5 3 0 0 3 3 3 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 AIF85357.1 - 1.3e-06 28.0 0.5 1.3e-06 28.0 0.5 2.8 3 1 0 3 3 3 1 Cupin domain AbiEi_2 PF09952.9 AIF85357.1 - 0.034 14.4 0.0 0.057 13.6 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system FMN_red PF03358.15 AIF85358.1 - 1e-27 96.8 0.0 1.2e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 AIF85358.1 - 4.9e-09 36.2 0.0 6.5e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Usp PF00582.26 AIF85358.1 - 0.0061 17.1 0.3 0.01 16.4 0.3 1.3 1 0 0 1 1 1 1 Universal stress protein family Flavodoxin_5 PF12724.7 AIF85358.1 - 0.031 14.5 0.0 0.046 14.0 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain Trypsin_2 PF13365.6 AIF85359.1 - 2.8e-36 125.7 2.0 2.8e-36 125.7 2.0 1.6 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 AIF85359.1 - 2.9e-17 62.7 0.4 1.7e-15 57.1 0.0 2.5 2 0 0 2 2 2 1 PDZ domain Trypsin PF00089.26 AIF85359.1 - 9e-14 51.8 0.1 1.7e-13 50.9 0.1 1.5 1 0 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 AIF85359.1 - 4.6e-11 42.4 2.3 8.8e-11 41.5 0.2 2.2 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 AIF85359.1 - 1.5e-05 25.2 0.1 0.00011 22.5 0.0 2.3 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.6 AIF85359.1 - 0.0027 17.6 0.0 0.0082 16.1 0.0 1.8 1 0 0 1 1 1 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 AIF85359.1 - 0.005 15.6 0.3 0.64 8.6 0.2 2.1 2 0 0 2 2 2 2 Peptidase S46 SUI1 PF01253.22 AIF85360.1 - 3.6e-14 53.0 0.3 5.3e-14 52.5 0.2 1.3 1 1 0 1 1 1 1 Translation initiation factor SUI1 SRI PF08236.11 AIF85360.1 - 0.005 17.0 0.7 0.0071 16.5 0.7 1.2 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain Img2 PF05046.14 AIF85360.1 - 0.0075 16.5 0.1 0.01 16.1 0.1 1.4 1 1 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) zf-met PF12874.7 AIF85361.1 - 0.00095 19.5 0.8 0.0015 18.9 0.8 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF629 PF04780.12 AIF85361.1 - 0.0053 15.3 0.2 0.0053 15.3 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF629) zf-C2H2 PF00096.26 AIF85361.1 - 0.0089 16.4 0.2 0.012 16.1 0.2 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF85361.1 - 0.011 16.5 0.3 0.014 16.1 0.3 1.2 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AIF85361.1 - 0.019 15.2 0.9 0.04 14.2 0.9 1.7 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 AIF85361.1 - 0.055 13.1 1.0 0.077 12.6 0.0 1.8 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger MarR PF01047.22 AIF85362.1 - 3e-06 27.1 0.1 6.1e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 MarR family DUF2250 PF10007.9 AIF85362.1 - 2.2e-05 24.5 0.0 0.00054 20.0 0.2 2.5 2 1 1 3 3 3 1 Uncharacterized protein conserved in archaea (DUF2250) MarR_2 PF12802.7 AIF85362.1 - 3.1e-05 23.8 0.0 9.4e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 MarR family HTH_5 PF01022.20 AIF85362.1 - 0.003 17.4 0.3 0.008 16.0 0.3 1.7 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIF85362.1 - 0.0065 16.5 0.1 0.017 15.2 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain RPA_C PF08784.11 AIF85362.1 - 0.015 16.0 1.4 0.028 15.1 1.4 1.4 1 0 0 1 1 1 0 Replication protein A C terminal TrmB PF01978.19 AIF85362.1 - 0.015 15.2 0.0 0.048 13.5 0.0 1.9 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Rrf2 PF02082.20 AIF85362.1 - 0.017 15.4 0.6 0.25 11.7 0.1 2.6 3 0 0 3 3 2 0 Transcriptional regulator HTH_24 PF13412.6 AIF85362.1 - 0.028 14.0 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding PaaX PF07848.12 AIF85362.1 - 0.034 14.4 0.1 0.063 13.5 0.1 1.4 1 0 0 1 1 1 0 PaaX-like protein HTH_27 PF13463.6 AIF85362.1 - 0.037 14.5 0.0 0.14 12.7 0.0 2.0 2 0 0 2 2 1 0 Winged helix DNA-binding domain GntR PF00392.21 AIF85362.1 - 0.047 13.3 0.1 0.16 11.7 0.1 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HxlR PF01638.17 AIF85362.1 - 0.05 13.5 0.1 0.13 12.1 0.1 1.7 1 0 0 1 1 1 0 HxlR-like helix-turn-helix DUF4423 PF14394.6 AIF85362.1 - 0.05 13.3 0.1 0.12 12.1 0.0 1.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4423) HTH_11 PF08279.12 AIF85362.1 - 0.069 13.1 0.1 0.23 11.4 0.1 1.9 2 0 0 2 2 2 0 HTH domain Proteasome PF00227.26 AIF85364.1 - 6.8e-49 165.9 0.6 7.7e-49 165.8 0.6 1.0 1 0 0 1 1 1 1 Proteasome subunit Proteasome PF00227.26 AIF85365.1 - 4.3e-41 140.5 0.0 5.1e-41 140.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit HxlR PF01638.17 AIF85366.1 - 1.1e-26 92.5 1.0 1.3e-26 92.2 1.0 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_34 PF13601.6 AIF85366.1 - 0.0044 17.2 0.1 0.0058 16.8 0.1 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain PadR PF03551.14 AIF85366.1 - 0.0044 17.0 0.1 0.0069 16.3 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family MarR PF01047.22 AIF85366.1 - 0.035 14.0 0.2 0.079 12.9 0.2 1.6 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 AIF85366.1 - 0.059 12.9 0.1 0.12 11.9 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 AIF85366.1 - 0.094 12.8 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Trans_reg_C PF00486.28 AIF85367.1 - 0.07 13.2 0.0 0.096 12.8 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal Polysacc_synt_C PF14667.6 AIF85368.1 - 0.024 14.7 3.1 2.4 8.2 0.1 2.9 2 1 1 3 3 3 0 Polysaccharide biosynthesis C-terminal domain HTH_45 PF14947.6 AIF85369.1 - 2.1e-08 34.0 0.5 2.6e-08 33.7 0.5 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix PadR PF03551.14 AIF85369.1 - 0.0021 17.9 0.0 0.0038 17.1 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family MarR PF01047.22 AIF85369.1 - 0.0093 15.9 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.6 AIF85369.1 - 0.024 14.8 0.2 0.034 14.3 0.2 1.4 1 1 0 1 1 1 0 Winged helix DNA-binding domain DUF4364 PF14277.6 AIF85369.1 - 0.028 14.2 0.0 0.034 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) TrmB PF01978.19 AIF85369.1 - 0.034 14.0 0.0 0.048 13.6 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 AIF85369.1 - 0.072 13.6 0.0 0.11 13.0 0.0 1.4 1 1 0 1 1 1 0 Winged helix DNA-binding domain DUF3051 PF11252.8 AIF85369.1 - 0.13 12.0 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3051) PepSY PF03413.19 AIF85370.1 - 0.0016 19.0 0.0 0.0029 18.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain BB_PF PF18063.1 AIF85370.1 - 0.056 13.0 0.1 0.073 12.7 0.1 1.2 1 0 0 1 1 1 0 Beta barrel Pore-forming domain ABC_membrane PF00664.23 AIF85372.1 - 0.27 10.9 0.3 3.6 7.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter transmembrane region Ammonium_transp PF00909.21 AIF85373.1 - 2.9e-116 388.4 34.3 3.7e-116 388.1 34.3 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family Glyco_hydro_57 PF03065.15 AIF85374.1 - 0.15 11.2 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 ResIII PF04851.15 AIF85375.1 - 1.8e-24 86.7 0.0 4.8e-24 85.3 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit XPB_DRD PF18458.1 AIF85375.1 - 7.6e-20 70.6 0.5 1.5e-19 69.6 0.5 1.5 1 0 0 1 1 1 1 Xeroderma pigmentosum group B helicase damage recognition domain ERCC3_RAD25_C PF16203.5 AIF85375.1 - 2.6e-18 66.2 0.1 6.3e-18 64.9 0.1 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C PF00271.31 AIF85375.1 - 3.1e-15 56.5 0.2 1e-14 54.8 0.0 2.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 AIF85375.1 - 4e-10 39.7 0.0 9.4e-10 38.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4196 PF13846.6 AIF85375.1 - 0.0081 16.4 1.8 0.017 15.4 1.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4196) Helicase_C_2 PF13307.6 AIF85375.1 - 0.014 15.5 0.6 0.22 11.7 0.0 3.0 2 2 2 4 4 4 0 Helicase C-terminal domain AAA_22 PF13401.6 AIF85375.1 - 0.027 14.7 0.0 0.14 12.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF790 PF05626.11 AIF85376.1 - 2.8e-96 322.6 0.0 1.8e-95 320.0 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF790) Phage_integrase PF00589.22 AIF85377.1 - 1.1e-15 57.9 0.1 2e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 Phage integrase family zinc_ribbon_2 PF13240.6 AIF85377.1 - 0.005 16.5 3.4 0.01 15.5 3.4 1.6 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 AIF85377.1 - 0.011 15.1 1.6 0.026 14.0 1.6 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Phage_int_SAM_1 PF02899.17 AIF85377.1 - 0.011 16.0 0.0 0.18 12.1 0.0 2.7 1 1 1 2 2 2 0 Phage integrase, N-terminal SAM-like domain OrfB_Zn_ribbon PF07282.11 AIF85377.1 - 0.021 14.8 1.1 0.065 13.2 0.2 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain zinc_ribbon_15 PF17032.5 AIF85377.1 - 0.048 14.4 1.7 1.1 10.0 0.4 2.4 2 0 0 2 2 2 0 zinc-ribbon family DZR PF12773.7 AIF85377.1 - 0.051 13.6 1.6 0.21 11.6 0.3 2.1 2 0 0 2 2 2 0 Double zinc ribbon Phage_int_SAM_4 PF13495.6 AIF85377.1 - 0.057 13.9 0.8 13 6.3 0.1 3.3 2 1 2 4 4 4 0 Phage integrase, N-terminal SAM-like domain YhfH PF14149.6 AIF85377.1 - 0.32 11.0 0.0 0.32 11.0 0.0 2.8 3 0 0 3 3 2 0 YhfH-like protein zf-tcix PF14952.6 AIF85377.1 - 1.8 8.3 10.6 2.3 7.9 2.3 2.4 1 1 1 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding UPF0547 PF10571.9 AIF85377.1 - 3.8 7.7 6.5 0.75 9.9 2.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 AAA_18 PF13238.6 AIF85380.1 - 4.8e-12 46.6 0.0 1.2e-11 45.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 AIF85380.1 - 5.1e-09 36.7 0.0 1.2e-08 35.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AIF85380.1 - 6.8e-05 23.1 0.0 0.00012 22.2 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AIF85380.1 - 0.00083 19.6 0.0 0.0017 18.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 AIF85380.1 - 0.0032 16.7 0.0 0.0042 16.3 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain dNK PF01712.19 AIF85380.1 - 0.0033 17.3 0.0 0.1 12.5 0.0 2.1 2 0 0 2 2 2 1 Deoxynucleoside kinase Cytidylate_kin2 PF13189.6 AIF85380.1 - 0.0034 17.5 0.0 0.86 9.7 0.0 2.1 2 0 0 2 2 2 1 Cytidylate kinase-like family Torsin PF06309.11 AIF85380.1 - 0.0074 16.4 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Torsin ADK PF00406.22 AIF85380.1 - 0.0077 16.3 0.0 0.014 15.5 0.0 1.4 1 1 0 1 1 1 1 Adenylate kinase CoaE PF01121.20 AIF85380.1 - 0.019 14.6 0.0 0.24 11.0 0.0 2.1 2 0 0 2 2 2 0 Dephospho-CoA kinase NTPase_1 PF03266.15 AIF85380.1 - 0.033 14.1 0.0 0.72 9.7 0.0 2.2 2 0 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 AIF85380.1 - 0.039 13.2 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Cytidylate_kin PF02224.18 AIF85380.1 - 0.04 13.7 0.0 0.059 13.1 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase ABC_tran PF00005.27 AIF85380.1 - 0.042 14.4 0.0 0.064 13.8 0.0 1.3 1 0 0 1 1 1 0 ABC transporter KAP_NTPase PF07693.14 AIF85380.1 - 0.052 12.8 0.0 0.054 12.7 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain TsaE PF02367.17 AIF85380.1 - 0.065 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE APS_kinase PF01583.20 AIF85380.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_29 PF13555.6 AIF85380.1 - 0.12 12.2 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SKI PF01202.22 AIF85380.1 - 0.13 12.4 0.0 0.91 9.6 0.0 2.0 2 0 0 2 2 2 0 Shikimate kinase ASCH PF04266.14 AIF85381.1 - 2.9e-05 24.6 0.0 4.8e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 ASCH domain N6-adenineMlase PF10237.9 AIF85382.1 - 9.1e-05 22.3 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase 1-cysPrx_C PF10417.9 AIF85382.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain of 1-Cys peroxiredoxin Radical_SAM PF04055.21 AIF85383.1 - 0.0001 22.7 0.0 0.00027 21.4 0.0 1.7 1 1 0 1 1 1 1 Radical SAM superfamily DUF4186 PF13811.6 AIF85384.1 - 3.6e-27 94.6 0.0 6e-27 93.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4186) Cript PF10235.9 AIF85384.1 - 0.26 11.9 0.0 0.26 11.9 0.0 2.4 2 1 0 2 2 2 0 Microtubule-associated protein CRIPT HTH_3 PF01381.22 AIF85385.1 - 1.9e-09 37.4 0.6 7.3e-09 35.6 0.8 2.0 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 AIF85385.1 - 2.6e-06 27.7 0.5 7.7e-06 26.2 0.5 1.9 1 1 0 1 1 1 1 Helix-turn-helix domain Peptidase_M78 PF06114.13 AIF85385.1 - 3e-06 27.2 0.0 9.3e-06 25.6 0.0 1.8 1 0 0 1 1 1 1 IrrE N-terminal-like domain HTH_19 PF12844.7 AIF85385.1 - 8.4e-05 22.5 2.9 0.0001 22.2 0.3 2.6 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_25 PF13413.6 AIF85385.1 - 0.00024 20.9 1.7 0.00052 19.8 0.7 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 AIF85385.1 - 0.00055 19.6 0.1 0.002 17.9 0.1 1.9 1 0 0 1 1 1 1 Homeodomain-like domain HTH_37 PF13744.6 AIF85385.1 - 0.00088 19.2 0.7 0.0025 17.7 0.7 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 AIF85385.1 - 0.0036 17.7 0.0 0.012 16.0 0.0 1.9 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain Pou PF00157.17 AIF85385.1 - 0.0091 15.9 0.3 0.026 14.5 0.1 1.9 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Peptidase_U49 PF10463.9 AIF85385.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase U49 YdaS_antitoxin PF15943.5 AIF85385.1 - 0.031 14.2 0.1 0.078 12.8 0.1 1.7 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT MPTase-PolyVal PF18818.1 AIF85385.1 - 0.031 14.3 0.0 0.073 13.1 0.0 1.6 1 0 0 1 1 1 0 Metallopeptidase superfamily domain AAA_18 PF13238.6 AIF85385.1 - 0.063 13.8 0.1 0.17 12.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain PepSY PF03413.19 AIF85387.1 - 0.0025 18.4 0.6 0.0025 18.4 0.6 2.2 2 1 0 2 2 2 1 Peptidase propeptide and YPEB domain BNR_2 PF13088.6 AIF85391.1 - 2.4e-07 30.4 11.3 0.0025 17.1 0.2 4.1 2 2 1 4 4 4 4 BNR repeat-like domain BNR PF02012.20 AIF85391.1 - 0.0026 17.5 29.4 0.71 10.1 0.5 7.1 6 0 0 6 6 6 4 BNR/Asp-box repeat Reprolysin_3 PF13582.6 AIF85394.1 - 0.0059 17.1 0.5 0.022 15.2 0.5 2.0 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 AIF85394.1 - 0.046 13.3 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) CarboxypepD_reg PF13620.6 AIF85394.1 - 0.095 13.0 7.8 0.18 12.1 7.8 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Peptidase_M54 PF07998.11 AIF85394.1 - 0.23 11.4 0.0 2.5 8.1 0.0 2.0 2 0 0 2 2 2 0 Peptidase family M54 SdrD_B PF17210.3 AIF85394.1 - 1.2 9.4 6.2 0.34 11.1 3.2 1.6 2 0 0 2 2 2 0 SdrD B-like domain Peptidase_A24 PF01478.18 AIF85396.1 - 0.85 10.1 11.1 3.1 8.3 11.1 1.9 1 1 0 1 1 1 0 Type IV leader peptidase family GPI2 PF06432.11 AIF85396.1 - 1.5 8.2 10.0 2.1 7.7 10.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase AbiEii PF08843.11 AIF85398.1 - 3.3e-31 109.1 2.6 4e-31 108.8 2.6 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase AbiEii toxin, Type IV TA system DUF1216 PF06746.11 AIF85398.1 - 0.062 13.3 0.7 1.4 8.9 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1216) AbiEi_1 PF09407.10 AIF85399.1 - 3.3e-12 46.9 0.0 3.4e-11 43.6 0.0 2.5 3 0 0 3 3 3 1 AbiEi antitoxin C-terminal domain NucS PF01939.16 AIF85399.1 - 1.1e-06 28.2 1.4 1.3e-06 27.9 0.2 1.7 2 0 0 2 2 2 1 Endonuclease NucS TrmB PF01978.19 AIF85399.1 - 0.00029 20.7 0.1 0.0098 15.8 0.1 2.6 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB AbiEi_4 PF13338.6 AIF85399.1 - 0.0038 17.4 0.0 0.011 15.8 0.0 1.8 1 0 0 1 1 1 1 Transcriptional regulator, AbiEi antitoxin AbiEi_3_N PF17194.4 AIF85399.1 - 0.011 15.8 0.0 0.027 14.5 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain CPSase_L_D2 PF02786.17 AIF85399.1 - 0.024 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain SfsA PF03749.13 AIF85399.1 - 0.024 14.5 0.0 0.072 13.0 0.0 1.8 1 0 0 1 1 1 0 Sugar fermentation stimulation protein RE domain Phage_pRha PF09669.10 AIF85399.1 - 0.11 13.1 0.3 0.53 10.9 0.1 2.2 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) TF_Zn_Ribbon PF08271.12 AIF85401.1 - 0.0017 17.8 0.2 0.003 17.0 0.2 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding ParBc PF02195.18 AIF85402.1 - 1.6e-06 28.3 0.4 4.4e-06 26.9 0.4 1.8 1 0 0 1 1 1 1 ParB-like nuclease domain DUF1456 PF07308.13 AIF85402.1 - 0.15 12.5 0.0 12 6.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) DUF4790 PF16037.5 AIF85403.1 - 0.018 15.5 0.0 0.037 14.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4790) DUF1286 PF06939.11 AIF85405.1 - 0.038 14.3 2.3 0.075 13.3 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1286) DUF4231 PF14015.6 AIF85406.1 - 0.99 9.9 3.2 3.8 8.0 3.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4231) PrgI PF12666.7 AIF85407.1 - 6.5e-07 30.0 0.9 1.1e-06 29.3 0.9 1.3 1 0 0 1 1 1 1 PrgI family protein CAMSAP_CH PF11971.8 AIF85407.1 - 0.019 14.8 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain FUSC_2 PF13515.6 AIF85407.1 - 0.048 13.8 0.8 0.065 13.4 0.8 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein-like AAA_10 PF12846.7 AIF85408.1 - 1.2e-13 50.7 0.0 7.4e-09 35.0 0.0 2.2 1 1 1 2 2 2 2 AAA-like domain DUF87 PF01935.17 AIF85408.1 - 2.3e-09 37.7 0.0 4.9e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Helicase HerA, central domain ABC_tran PF00005.27 AIF85408.1 - 0.023 15.2 0.0 8 7.0 0.0 2.6 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 AIF85408.1 - 0.053 13.9 0.0 0.097 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Pox_A32 PF04665.12 AIF85408.1 - 0.057 12.9 0.0 0.19 11.2 0.0 1.8 2 0 0 2 2 2 0 Poxvirus A32 protein ResIII PF04851.15 AIF85408.1 - 0.09 12.8 0.0 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_16 PF13191.6 AIF85408.1 - 0.12 12.8 0.1 1.3 9.4 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain GerE PF00196.19 AIF85408.1 - 0.22 11.1 1.0 0.41 10.2 0.1 1.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family CarboxypepD_reg PF13620.6 AIF85410.1 - 2e-07 31.2 2.3 3.8e-07 30.3 2.3 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Reprolysin_5 PF13688.6 AIF85410.1 - 0.0054 16.9 1.6 0.011 15.9 0.7 2.0 2 1 0 2 2 2 1 Metallo-peptidase family M12 AglB_L1 PF18079.1 AIF85410.1 - 0.016 15.5 0.9 0.037 14.3 1.0 1.6 1 1 0 1 1 1 0 Archaeal glycosylation protein B long peripheral domain Peptidase_M54 PF07998.11 AIF85410.1 - 0.028 14.4 0.0 0.048 13.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 CarbopepD_reg_2 PF13715.6 AIF85410.1 - 0.055 13.5 0.4 0.27 11.3 0.4 2.0 1 1 0 1 1 1 0 CarboxypepD_reg-like domain HxlR PF01638.17 AIF85412.1 - 0.00071 19.4 0.2 0.0011 18.8 0.2 1.5 1 1 0 1 1 1 1 HxlR-like helix-turn-helix Penicillinase_R PF03965.16 AIF85412.1 - 0.045 14.1 0.1 0.058 13.8 0.1 1.2 1 0 0 1 1 1 0 Penicillinase repressor MarR PF01047.22 AIF85412.1 - 0.056 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_27 PF13463.6 AIF85412.1 - 0.064 13.8 0.2 0.12 12.9 0.2 1.5 1 1 0 1 1 1 0 Winged helix DNA-binding domain MarR_2 PF12802.7 AIF85412.1 - 0.077 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 MarR family DUF1778 PF08681.11 AIF85413.1 - 0.075 13.0 0.1 0.31 11.0 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1778) Nic96 PF04097.14 AIF85413.1 - 0.12 10.8 0.0 0.18 10.2 0.0 1.2 1 0 0 1 1 1 0 Nup93/Nic96 HicB PF05534.12 AIF85417.1 - 0.00034 20.4 0.0 0.00066 19.5 0.0 1.5 1 0 0 1 1 1 1 HicB family RHH_5 PF07878.11 AIF85417.1 - 0.00067 19.5 0.0 0.0017 18.2 0.0 1.7 1 0 0 1 1 1 1 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 RHH_1 PF01402.21 AIF85417.1 - 0.041 13.8 1.8 0.71 9.9 0.0 2.4 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family TRCF PF03461.15 AIF85418.1 - 0.0082 16.5 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 TRCF domain Radical_SAM PF04055.21 AIF85418.1 - 0.033 14.6 0.1 0.039 14.3 0.1 1.3 1 1 0 1 1 1 0 Radical SAM superfamily HTH_30 PF13556.6 AIF85418.1 - 0.057 13.2 0.5 0.16 11.8 0.1 1.8 2 0 0 2 2 2 0 PucR C-terminal helix-turn-helix domain C1_1 PF00130.22 AIF85419.1 - 0.0075 16.1 7.4 0.75 9.7 4.7 2.3 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Lar_restr_allev PF14354.6 AIF85419.1 - 0.8 10.1 9.2 68 3.9 9.1 2.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar LBP_BPI_CETP PF01273.25 AIF85420.1 - 0.15 11.6 0.1 0.19 11.3 0.1 1.0 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain Sar8_2 PF03058.14 AIF85422.1 - 0.71 10.5 4.4 0.82 10.2 4.4 1.1 1 0 0 1 1 1 0 Sar8.2 family DUF4366 PF14283.6 AIF85423.1 - 0.01 15.9 0.0 0.012 15.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) NCE101 PF11654.8 AIF85423.1 - 0.045 13.5 0.0 0.08 12.7 0.0 1.4 1 0 0 1 1 1 0 Non-classical export protein 1 CbtA PF09490.10 AIF85423.1 - 0.062 13.1 0.0 0.067 13.0 0.0 1.0 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) DUF2834 PF11196.8 AIF85423.1 - 0.17 12.3 0.0 0.21 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2834) DUF5092 PF17010.5 AIF85426.1 - 0.053 13.4 0.0 0.076 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5092) zf-C2H2_2 PF12756.7 AIF85427.1 - 0.00093 19.5 0.0 0.0013 19.0 0.0 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 AIF85427.1 - 0.00095 19.5 0.3 0.0015 18.9 0.3 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIF85427.1 - 0.0016 19.1 0.1 0.003 18.2 0.1 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AIF85427.1 - 0.039 14.0 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_9 PF16293.5 AIF85427.1 - 0.043 13.7 0.0 0.092 12.6 0.0 1.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-C2H2_jaz PF12171.8 AIF85427.1 - 0.052 13.8 0.0 0.096 13.0 0.0 1.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 AIF85427.1 - 0.083 13.0 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Zinc ribbon domain zf-H2C2_2 PF13465.6 AIF85427.1 - 0.1 13.0 1.4 0.18 12.3 0.2 1.9 2 0 0 2 2 2 0 Zinc-finger double domain Chlorosome_CsmC PF11098.8 AIF85429.1 - 0.016 15.2 1.5 0.016 15.2 1.5 1.9 2 0 0 2 2 2 0 Chlorosome envelope protein C Grg1 PF11034.8 AIF85429.1 - 0.14 12.4 0.8 0.32 11.2 0.8 1.6 1 0 0 1 1 1 0 Glucose-repressible protein Grg1 Coiled-coil_56 PF09813.9 AIF85429.1 - 0.26 11.4 0.3 0.51 10.4 0.1 1.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 F5_F8_type_C PF00754.25 AIF85432.1 - 8e-17 61.5 1.3 1.5e-16 60.7 0.4 1.8 2 0 0 2 2 2 1 F5/8 type C domain Tnp_22_trimer PF17489.2 AIF85433.1 - 0.016 15.2 0.7 0.019 14.9 0.2 1.5 2 0 0 2 2 2 0 L1 transposable element trimerization domain bZIP_2 PF07716.15 AIF85433.1 - 0.031 14.4 0.1 0.039 14.0 0.1 1.3 1 1 0 1 1 1 0 Basic region leucine zipper bZIP_1 PF00170.21 AIF85433.1 - 0.041 14.0 0.2 0.042 14.0 0.2 1.1 1 0 0 1 1 1 0 bZIP transcription factor SlyX PF04102.12 AIF85433.1 - 0.13 12.9 1.2 0.2 12.3 0.6 1.6 1 1 1 2 2 2 0 SlyX DUF2524 PF10732.9 AIF85436.1 - 4e-06 27.0 0.6 7.6e-06 26.1 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2524) ETRAMP PF09716.10 AIF85436.1 - 4.2 7.5 7.3 0.37 10.9 1.3 2.2 2 1 1 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) DASH_Dad1 PF08649.10 AIF85437.1 - 0.031 14.5 0.0 0.065 13.4 0.0 1.6 1 1 1 2 2 2 0 DASH complex subunit Dad1 Hemerythrin PF01814.23 AIF85438.1 - 1.2e-08 35.6 10.0 2.9e-08 34.4 10.0 1.7 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain ParD_antitoxin PF03693.14 AIF85438.1 - 0.023 15.1 0.4 0.11 12.9 0.1 2.0 1 1 1 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Fer4 PF00037.27 AIF85439.1 - 2.9e-11 42.7 10.2 8.3e-06 25.4 0.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 AIF85439.1 - 4e-10 40.1 2.2 3.7e-05 24.2 0.7 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIF85439.1 - 2e-08 35.0 2.4 5.9e-05 23.9 0.6 2.5 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 AIF85439.1 - 5.2e-08 32.9 1.4 0.00023 21.2 0.2 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIF85439.1 - 5.6e-08 32.8 15.8 1.8e-06 27.9 6.5 2.4 2 1 1 3 3 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 AIF85439.1 - 7.9e-08 32.4 6.6 2.9e-07 30.5 6.7 1.8 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIF85439.1 - 3.2e-07 30.1 10.8 0.00053 20.0 3.2 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 AIF85439.1 - 7e-06 26.4 21.3 0.00026 21.4 7.2 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_13 PF13370.6 AIF85439.1 - 6e-05 23.5 7.5 0.054 14.0 0.3 2.8 3 0 0 3 3 3 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_17 PF13534.6 AIF85439.1 - 8.3e-05 23.1 4.7 0.00076 20.0 5.7 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIF85439.1 - 0.00015 21.6 9.8 0.016 15.3 3.3 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 AIF85439.1 - 0.00044 20.5 7.3 0.031 14.8 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_22 PF17179.4 AIF85439.1 - 0.00067 20.4 1.1 1.8 9.4 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_18 PF13746.6 AIF85439.1 - 0.0011 19.2 7.8 0.0042 17.3 5.7 2.2 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_15 PF13459.6 AIF85439.1 - 0.0059 17.3 8.0 0.037 14.8 0.1 2.8 2 1 0 2 2 2 1 4Fe-4S single cluster domain Fer4_3 PF12798.7 AIF85439.1 - 0.018 15.9 13.1 0.93 10.6 5.6 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 AIF85439.1 - 0.21 11.7 3.7 11 6.3 0.0 2.6 2 1 1 3 3 3 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Hemerythrin PF01814.23 AIF85441.1 - 8.9e-10 39.3 5.7 2.6e-09 37.8 6.0 1.5 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain Glyco_hydro_46 PF01374.18 AIF85441.1 - 0.05 13.2 0.1 0.058 13.0 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 Orbi_VP5 PF00901.17 AIF85441.1 - 0.052 11.9 2.3 0.055 11.9 2.3 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 Alpha-mann_mid PF09261.11 AIF85441.1 - 0.09 12.9 1.7 0.2 11.9 1.7 1.6 1 1 0 1 1 1 0 Alpha mannosidase middle domain HU-CCDC81_bac_2 PF18175.1 AIF85441.1 - 0.3 11.0 2.4 0.78 9.7 0.0 2.5 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 CDC37_N PF03234.14 AIF85441.1 - 0.44 11.5 5.3 0.79 10.6 5.4 1.4 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding GTA_holin_3TM PF11351.8 AIF85441.1 - 0.7 10.4 3.2 0.77 10.3 0.1 2.2 2 1 0 2 2 2 0 Holin of 3TMs, for gene-transfer release DUF488 PF04343.13 AIF85442.1 - 4.3e-26 91.9 0.2 5.3e-26 91.6 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF488 EF-hand_14 PF17959.1 AIF85442.1 - 0.041 14.2 0.0 0.071 13.5 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain SoDot-IcmSS PF16848.5 AIF85443.1 - 0.068 13.1 0.6 0.086 12.8 0.6 1.1 1 0 0 1 1 1 0 Substrate of the Dot/Icm secretion system, putative UvdE PF03851.14 AIF85444.1 - 0.0095 15.2 0.0 0.0099 15.2 0.0 1.0 1 0 0 1 1 1 1 UV-endonuclease UvdE NitrOD2 PF18550.1 AIF85446.1 - 2e-26 92.1 0.0 2.4e-26 91.9 0.0 1.0 1 0 0 1 1 1 1 Nitrososphaera output domain 2 eRF1_2 PF03464.15 AIF85446.1 - 0.11 12.8 0.1 0.17 12.2 0.1 1.2 1 0 0 1 1 1 0 eRF1 domain 2 HEAT_2 PF13646.6 AIF85447.1 - 0.0054 17.1 0.0 0.01 16.2 0.0 1.5 1 0 0 1 1 1 1 HEAT repeats TraG_N PF07916.11 AIF85447.1 - 0.037 12.9 0.1 0.041 12.7 0.1 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Cid2 PF09774.9 AIF85447.1 - 0.089 13.2 2.1 0.12 12.8 2.0 1.2 1 1 0 1 1 1 0 Caffeine-induced death protein 2 HTH_27 PF13463.6 AIF85448.1 - 3e-06 27.6 2.5 0.7 10.4 0.0 4.6 4 0 0 4 4 4 2 Winged helix DNA-binding domain TrmB PF01978.19 AIF85448.1 - 4.7e-06 26.4 0.9 0.14 12.1 0.0 3.6 3 0 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 AIF85448.1 - 0.0001 22.1 0.7 0.27 11.2 0.0 2.9 2 0 0 2 2 2 2 HTH domain HTH_24 PF13412.6 AIF85448.1 - 0.00055 19.4 1.1 1.6 8.3 0.0 4.0 4 0 0 4 4 4 1 Winged helix-turn-helix DNA-binding Trp_repressor PF01371.19 AIF85448.1 - 0.00082 19.5 0.1 0.17 12.1 0.0 2.8 2 0 0 2 2 2 1 Trp repressor protein DUF4423 PF14394.6 AIF85448.1 - 0.0013 18.5 0.8 1.9 8.2 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4423) Penicillinase_R PF03965.16 AIF85448.1 - 0.0015 18.9 0.9 0.061 13.7 0.1 3.0 2 1 0 2 2 2 1 Penicillinase repressor HTH_20 PF12840.7 AIF85448.1 - 0.0024 17.9 0.0 5.7 7.1 0.0 3.4 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_DeoR PF08220.12 AIF85448.1 - 0.0033 17.1 0.3 0.014 15.1 0.2 2.1 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain Cullin_Nedd8 PF10557.9 AIF85448.1 - 0.0073 16.3 1.9 7.7 6.6 0.2 3.7 3 0 0 3 3 3 1 Cullin protein neddylation domain MarR_2 PF12802.7 AIF85448.1 - 0.0083 16.0 0.1 2.6 8.0 0.0 3.7 4 0 0 4 4 4 1 MarR family PaaX PF07848.12 AIF85448.1 - 0.0092 16.2 0.0 0.029 14.6 0.0 1.8 1 0 0 1 1 1 1 PaaX-like protein HTH_12 PF08461.10 AIF85448.1 - 0.038 14.0 1.1 0.11 12.4 0.5 2.1 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain HTH_36 PF13730.6 AIF85448.1 - 0.041 13.9 0.2 5.1 7.1 0.1 2.9 2 0 0 2 2 2 0 Helix-turn-helix domain PD40 PF07676.12 AIF85450.1 - 1.1e-06 28.4 18.8 0.015 15.2 0.2 6.0 7 0 0 7 7 7 4 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 AIF85450.1 - 0.00018 21.4 0.0 0.00077 19.3 0.0 2.1 1 1 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain DPPIV_N PF00930.21 AIF85450.1 - 0.00076 18.3 0.2 1.6 7.4 0.0 3.2 3 1 0 3 3 3 3 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF4394 PF14339.6 AIF85450.1 - 0.0078 15.6 3.0 0.081 12.3 0.4 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4394) Otopetrin PF03189.13 AIF85453.1 - 0.042 12.7 0.6 0.059 12.2 0.6 1.2 1 0 0 1 1 1 0 Otopetrin SdrD_B PF17210.3 AIF85455.1 - 2.8e-17 63.0 15.2 1e-06 29.0 1.7 6.5 4 1 1 5 5 5 3 SdrD B-like domain CarboxypepD_reg PF13620.6 AIF85455.1 - 1.7e-16 60.2 15.3 1.9e-06 28.1 0.3 8.1 8 1 1 9 9 9 4 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 AIF85455.1 - 6.6e-05 22.8 15.6 0.11 12.5 0.2 6.4 6 0 0 6 6 6 2 Bacterial Ig-like domain (group 1) Big_5 PF13205.6 AIF85455.1 - 0.00038 21.1 4.3 0.0015 19.2 0.7 3.4 2 0 0 2 2 2 1 Bacterial Ig-like domain Big_6 PF17936.1 AIF85455.1 - 0.0022 18.2 8.5 0.096 13.0 0.0 6.4 6 1 0 6 6 6 1 Bacterial Ig domain Invasin_D3 PF09134.10 AIF85455.1 - 0.024 14.9 26.6 0.67 10.3 0.1 7.8 7 1 0 7 7 7 0 Invasin, domain 3 phage_tail_N PF08400.10 AIF85455.1 - 0.048 13.7 0.8 8.7 6.3 0.1 3.2 3 0 0 3 3 3 0 Prophage tail fibre N-terminal PAP2_C PF14360.6 AIF85458.1 - 0.0079 16.7 2.2 0.01 16.4 2.2 1.2 1 0 0 1 1 1 1 PAP2 superfamily C-terminal DUF4896 PF16237.5 AIF85458.1 - 0.031 14.1 1.7 0.42 10.5 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4896) UPF0767 PF15990.5 AIF85458.1 - 0.074 13.2 0.6 0.13 12.4 0.6 1.4 1 0 0 1 1 1 0 UPF0767 family Phage_holin_3_6 PF07332.11 AIF85458.1 - 0.086 12.9 1.5 0.11 12.5 1.5 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF202 PF02656.15 AIF85458.1 - 1.1 9.7 5.3 1.7 9.1 5.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF4149 PF13664.6 AIF85459.1 - 0.056 13.8 1.8 0.082 13.2 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) Arteri_Gl PF00951.18 AIF85459.1 - 0.26 11.1 3.7 0.16 11.8 1.4 1.7 1 1 0 1 1 1 0 Arterivirus GL envelope glycoprotein PadR PF03551.14 AIF85461.1 - 0.052 13.5 0.0 0.074 13.0 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family Hemerythrin PF01814.23 AIF85465.1 - 0.00048 20.7 0.2 0.00051 20.7 0.2 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain F-112 PF09645.10 AIF85465.1 - 0.11 12.6 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 F-112 protein Pox_A_type_inc PF04508.12 AIF85466.1 - 0.007 16.2 1.3 0.067 13.1 0.2 2.1 2 0 0 2 2 2 1 Viral A-type inclusion protein repeat DivIC PF04977.15 AIF85466.1 - 0.028 14.2 0.3 0.036 13.8 0.3 1.3 1 1 0 1 1 1 0 Septum formation initiator CCDC92 PF14916.6 AIF85466.1 - 0.11 12.2 0.2 0.18 11.6 0.1 1.4 1 1 0 1 1 1 0 Coiled-coil domain of unknown function Aldedh PF00171.22 AIF85467.1 - 2.2e-153 511.1 2.7 2.5e-153 510.9 2.7 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 AIF85467.1 - 0.018 14.1 0.9 0.22 10.5 0.0 2.1 1 1 1 2 2 2 0 Acyl-CoA reductase (LuxC) RRF PF01765.19 AIF85467.1 - 0.18 11.7 2.2 0.51 10.3 2.2 1.7 1 0 0 1 1 1 0 Ribosome recycling factor ADH_N PF08240.12 AIF85468.1 - 3.3e-33 113.8 0.3 5.4e-33 113.1 0.3 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIF85468.1 - 3.3e-27 95.0 0.5 4.4e-26 91.4 0.1 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AIF85468.1 - 1.1e-13 52.4 0.5 1.7e-13 51.8 0.1 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AIF85468.1 - 8.8e-05 22.1 0.3 0.00021 20.9 0.3 1.6 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 AIF85468.1 - 0.00015 21.1 0.4 0.00023 20.6 0.4 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Hydant_A_N PF05378.13 AIF85468.1 - 0.0016 18.2 0.1 0.0032 17.2 0.1 1.4 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase N-terminal region TrkA_N PF02254.18 AIF85468.1 - 0.03 14.6 0.2 0.066 13.5 0.2 1.6 1 0 0 1 1 1 0 TrkA-N domain PrmA PF06325.13 AIF85468.1 - 0.05 13.0 0.7 0.071 12.5 0.7 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) UDPG_MGDP_dh_N PF03721.14 AIF85468.1 - 0.058 13.0 0.5 0.087 12.4 0.5 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HhH-GPD PF00730.25 AIF85469.1 - 3.1e-17 63.0 0.0 4.6e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein DUF488 PF04343.13 AIF85470.1 - 9.2e-30 103.7 0.0 1.2e-29 103.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF488 NumbF PF06311.12 AIF85470.1 - 0.046 14.3 0.0 0.083 13.4 0.0 1.4 1 0 0 1 1 1 0 NUMB domain Y_phosphatase3 PF13350.6 AIF85470.1 - 0.16 11.9 0.0 0.21 11.5 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family Fer4 PF00037.27 AIF85471.1 - 1.9e-11 43.2 10.4 6e-06 25.8 0.9 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 AIF85471.1 - 3.3e-10 40.4 3.5 2.5e-05 24.8 0.8 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIF85471.1 - 6.2e-09 36.7 2.3 2.8e-05 25.0 0.7 2.5 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 AIF85471.1 - 2.3e-08 34.0 5.2 1.2e-06 28.6 6.1 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIF85471.1 - 4.6e-08 33.1 3.4 0.0003 20.9 0.6 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 AIF85471.1 - 1e-07 32.0 6.6 7.6e-07 29.2 7.1 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIF85471.1 - 1e-07 32.3 0.5 0.0076 16.7 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIF85471.1 - 1.4e-07 31.2 10.6 0.00046 20.1 3.2 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 AIF85471.1 - 6.7e-05 23.4 4.2 0.00077 20.0 5.3 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 AIF85471.1 - 6.7e-05 23.4 7.5 0.059 13.9 0.3 2.8 3 0 0 3 3 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_2 PF12797.7 AIF85471.1 - 0.00012 21.9 9.8 0.014 15.4 3.3 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.6 AIF85471.1 - 0.0002 21.5 9.0 0.0017 18.6 1.3 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 AIF85471.1 - 0.00057 20.2 7.3 0.027 15.0 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_22 PF17179.4 AIF85471.1 - 0.0015 19.4 1.1 1.8 9.4 0.7 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_15 PF13459.6 AIF85471.1 - 0.0048 17.6 8.0 0.049 14.4 0.2 2.7 3 0 0 3 3 2 2 4Fe-4S single cluster domain Fer4_3 PF12798.7 AIF85471.1 - 0.011 16.6 13.4 0.82 10.7 5.6 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 AIF85471.1 - 0.063 13.4 3.9 5.7 7.1 0.0 2.8 2 1 1 3 3 3 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Patatin PF01734.22 AIF85472.1 - 1.8e-18 67.5 0.0 6.6e-18 65.6 0.0 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase DUF3734 PF12536.8 AIF85472.1 - 0.0029 17.9 0.2 0.0065 16.8 0.2 1.7 1 1 0 1 1 1 1 Patatin phospholipase NAD_binding_1 PF00175.21 AIF85473.1 - 1.1e-19 71.1 0.0 1.9e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Rieske PF00355.26 AIF85473.1 - 4.4e-13 49.0 0.0 8.7e-13 48.0 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain FAD_binding_6 PF00970.24 AIF85473.1 - 1.1e-07 32.1 0.0 2.3e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AIF85473.1 - 0.0012 18.9 0.0 0.074 13.2 0.0 2.5 2 1 0 2 2 2 1 Ferric reductase NAD binding domain CBS PF00571.28 AIF85475.1 - 3.2e-29 101.1 2.1 1.4e-13 51.1 0.2 2.1 2 0 0 2 2 2 2 CBS domain HxlR PF01638.17 AIF85477.1 - 5.8e-20 70.9 0.0 8.5e-20 70.4 0.0 1.3 1 0 0 1 1 1 1 HxlR-like helix-turn-helix MarR PF01047.22 AIF85477.1 - 0.0021 17.9 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_12 PF08461.10 AIF85477.1 - 0.0071 16.3 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain AmoC PF04896.12 AIF85479.1 - 3e-13 49.6 5.5 3.5e-13 49.4 5.5 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C RTA1 PF04479.13 AIF85479.1 - 0.019 14.6 0.1 0.028 14.0 0.1 1.2 1 0 0 1 1 1 0 RTA1 like protein Fer4 PF00037.27 AIF85480.1 - 3.6e-10 39.2 11.6 3.5e-06 26.6 1.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 AIF85480.1 - 1.3e-09 38.4 2.9 0.00032 21.2 0.9 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 AIF85480.1 - 1.6e-07 31.4 6.8 9e-07 29.0 7.1 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIF85480.1 - 1.8e-07 31.2 6.8 7.2e-06 26.0 7.4 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIF85480.1 - 6.8e-07 30.1 6.0 0.00087 20.2 1.0 2.5 3 0 0 3 3 2 2 4Fe-4S double cluster binding domain Fer4_6 PF12837.7 AIF85480.1 - 1e-06 28.5 12.4 0.0026 17.7 1.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 AIF85480.1 - 1.3e-05 25.2 8.7 0.0012 18.9 8.7 2.3 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 AIF85480.1 - 2.7e-05 24.6 5.0 0.0001 22.8 5.1 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIF85480.1 - 3e-05 24.4 7.0 0.0022 18.4 8.5 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_13 PF13370.6 AIF85480.1 - 7.6e-05 23.2 8.8 0.011 16.2 0.4 2.5 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_2 PF12797.7 AIF85480.1 - 0.00039 20.3 11.4 0.05 13.7 3.6 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 AIF85480.1 - 0.00043 20.6 6.5 0.039 14.4 1.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.6 AIF85480.1 - 0.00046 20.4 5.9 0.00051 20.2 4.1 1.9 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_15 PF13459.6 AIF85480.1 - 0.0014 19.3 7.9 0.014 16.2 1.8 2.6 2 1 0 2 2 2 1 4Fe-4S single cluster domain Fer4_22 PF17179.4 AIF85480.1 - 0.003 18.4 0.2 3.4 8.6 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIF85480.1 - 0.016 16.1 13.6 0.89 10.6 0.7 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 AIF85480.1 - 0.13 12.4 3.0 5.5 7.2 0.1 2.8 2 1 1 3 3 3 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Abhydrolase_1 PF00561.20 AIF85481.1 - 7.3e-24 84.8 0.0 9.2e-23 81.2 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIF85481.1 - 9.2e-16 59.1 0.0 1.1e-15 58.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 AIF85481.1 - 4.5e-14 51.8 0.0 5.6e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 Ndr family Hydrolase_4 PF12146.8 AIF85481.1 - 1.5e-12 47.3 0.0 2.6e-12 46.5 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 AIF85481.1 - 6.8e-10 38.9 0.0 9.6e-07 28.7 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Thioesterase PF00975.20 AIF85481.1 - 0.0003 21.0 0.0 0.0011 19.2 0.0 1.8 1 1 0 1 1 1 1 Thioesterase domain DUF1057 PF06342.12 AIF85481.1 - 0.00034 19.7 0.0 0.00058 19.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) PGAP1 PF07819.13 AIF85481.1 - 0.0054 16.5 0.1 0.022 14.5 0.0 1.9 1 1 0 2 2 2 1 PGAP1-like protein UPF0227 PF05728.12 AIF85481.1 - 0.019 14.9 0.0 4.7 7.1 0.0 2.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0227) Abhydrolase_8 PF06259.12 AIF85481.1 - 0.044 13.4 0.0 0.084 12.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_3 PF07859.13 AIF85481.1 - 0.063 13.1 0.0 0.15 11.9 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 AIF85481.1 - 0.069 12.6 0.0 0.35 10.3 0.0 2.2 2 1 0 2 2 2 0 Prolyl oligopeptidase family Tim17 PF02466.19 AIF85481.1 - 0.072 13.5 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Lipase_3 PF01764.25 AIF85481.1 - 0.1 12.5 0.1 0.68 9.8 0.0 2.0 1 1 1 2 2 2 0 Lipase (class 3) Patatin PF01734.22 AIF85481.1 - 0.12 12.5 0.3 16 5.6 0.0 2.1 1 1 1 2 2 2 0 Patatin-like phospholipase Usp PF00582.26 AIF85482.1 - 8.9e-18 65.2 3.8 1.7e-17 64.3 3.8 1.4 1 1 0 1 1 1 1 Universal stress protein family DHHA1 PF02272.19 AIF85482.1 - 0.12 12.8 5.5 0.078 13.4 3.4 1.7 2 1 0 2 2 2 0 DHHA1 domain Na_H_Exchanger PF00999.21 AIF85483.1 - 6.2e-52 176.7 51.1 7.7e-52 176.4 51.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Kazal_3 PF18434.1 AIF85484.1 - 0.015 15.0 0.3 0.026 14.3 0.3 1.4 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain GSDH PF07995.11 AIF85485.1 - 9.5e-68 228.9 0.1 3.4e-54 184.4 0.5 2.1 2 0 0 2 2 2 2 Glucose / Sorbosone dehydrogenase Tachylectin PF14517.6 AIF85485.1 - 0.0037 16.9 0.1 0.5 9.9 0.1 3.4 3 1 1 4 4 4 1 Tachylectin DUF5122 PF17164.4 AIF85485.1 - 0.09 13.1 0.4 2.6 8.4 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller Reg_prop PF07494.11 AIF85485.1 - 0.14 12.5 0.0 42 4.9 0.0 3.8 3 0 0 3 3 3 0 Two component regulator propeller FMN_red PF03358.15 AIF85486.1 - 3.2e-09 36.7 0.0 3.7e-09 36.5 0.0 1.0 1 0 0 1 1 1 1 NADPH-dependent FMN reductase FMN_red PF03358.15 AIF85487.1 - 1.3e-10 41.2 0.0 1.5e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Usp PF00582.26 AIF85488.1 - 2.6e-32 112.2 1.4 3e-32 112.1 1.4 1.0 1 0 0 1 1 1 1 Universal stress protein family CBS PF00571.28 AIF85489.1 - 1.6e-40 137.3 7.2 1.5e-11 44.6 0.2 4.3 4 0 0 4 4 4 4 CBS domain SMC_hinge PF06470.13 AIF85489.1 - 0.0016 18.7 0.9 0.005 17.1 0.1 2.2 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain Vps35 PF03635.17 AIF85489.1 - 0.045 12.2 6.7 0.39 9.2 0.4 2.0 1 1 1 2 2 2 0 Vacuolar protein sorting-associated protein 35 Na_sulph_symp PF00939.19 AIF85491.1 - 4.8e-58 197.3 28.0 6.2e-58 197.0 28.0 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 AIF85491.1 - 2.2e-21 76.4 63.5 1.8e-10 40.6 10.6 3.3 2 1 1 3 3 3 3 Citrate transporter Patatin PF01734.22 AIF85492.1 - 3.6e-21 76.3 0.0 1.3e-20 74.5 0.0 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase DUF3734 PF12536.8 AIF85492.1 - 0.0062 16.9 1.8 0.015 15.6 1.8 1.7 1 1 0 1 1 1 1 Patatin phospholipase ATP-cone PF03477.16 AIF85493.1 - 1.4e-13 51.2 0.2 2.1e-13 50.6 0.2 1.3 1 0 0 1 1 1 1 ATP cone domain UPF0086 PF01868.16 AIF85494.1 - 0.01 15.7 0.0 2.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function UPF0086 Kelch_2 PF07646.15 AIF85494.1 - 0.011 15.7 0.0 3.3 7.8 0.0 2.3 2 0 0 2 2 2 0 Kelch motif HCBP_related PF06594.11 AIF85494.1 - 0.039 13.9 0.2 1.6 8.7 0.0 2.3 2 0 0 2 2 2 0 Haemolysin-type calcium binding protein related domain Kelch_1 PF01344.25 AIF85494.1 - 0.14 11.8 0.1 0.48 10.1 0.0 1.9 2 0 0 2 2 2 0 Kelch motif NTP_transf_9 PF04248.12 AIF85494.1 - 0.15 12.0 0.0 18 5.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF427) zf-C2H2 PF00096.26 AIF85495.1 - 0.00031 21.0 0.2 0.00031 21.0 0.2 1.6 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-met PF12874.7 AIF85495.1 - 0.00043 20.6 0.5 0.00043 20.6 0.5 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 AIF85495.1 - 0.012 15.9 0.5 0.014 15.7 0.5 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 AIF85495.1 - 0.015 16.1 0.2 0.015 16.1 0.2 1.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-DBF PF07535.12 AIF85495.1 - 0.04 14.0 0.7 0.06 13.5 0.7 1.3 1 0 0 1 1 1 0 DBF zinc finger zf-H2C2_2 PF13465.6 AIF85495.1 - 0.044 14.2 1.2 0.67 10.5 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AIF85495.1 - 0.068 13.5 0.2 0.068 13.5 0.2 1.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Copper-bind PF00127.20 AIF85496.1 - 1e-12 48.4 0.1 1.6e-12 47.8 0.1 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF85496.1 - 5.5e-07 29.7 0.0 1.4e-06 28.4 0.0 1.6 1 1 0 1 1 1 1 Cupredoxin-like domain C1-set PF07654.15 AIF85496.1 - 0.032 14.6 0.1 0.054 13.9 0.1 1.5 1 0 0 1 1 1 0 Immunoglobulin C1-set domain DUF2175 PF09943.9 AIF85496.1 - 0.17 12.2 0.1 0.32 11.3 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Usp PF00582.26 AIF85498.1 - 4.6e-30 105.0 0.1 5.8e-30 104.6 0.1 1.1 1 0 0 1 1 1 1 Universal stress protein family BpuJI_N PF11564.8 AIF85498.1 - 0.062 12.5 0.1 0.076 12.2 0.1 1.1 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal DUF4924 PF16271.5 AIF85498.1 - 0.1 12.6 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) Phosphodiest PF01663.22 AIF85498.1 - 0.12 12.0 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase RPN13_C PF16550.5 AIF85500.1 - 0.046 13.9 1.3 0.31 11.2 1.0 2.2 1 1 1 2 2 2 0 UCH-binding domain Cluap1 PF10234.9 AIF85500.1 - 0.14 11.6 1.3 0.25 10.7 1.3 1.4 1 0 0 1 1 1 0 Clusterin-associated protein-1 PI3K_1B_p101 PF10486.9 AIF85500.1 - 0.36 8.6 6.2 0.43 8.3 6.2 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Macoilin PF09726.9 AIF85500.1 - 2.6 6.5 11.0 3.5 6.1 11.0 1.2 1 0 0 1 1 1 0 Macoilin family DUF515 PF04415.12 AIF85500.1 - 3.6 5.9 17.2 4.8 5.5 17.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Asn_synthase PF00733.21 AIF85502.1 - 8e-55 186.9 0.0 1.8e-32 113.4 0.0 2.3 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 AIF85502.1 - 3.6e-29 101.2 0.2 9.3e-14 51.4 0.0 2.6 2 1 1 3 3 3 2 Glutamine amidotransferase domain GATase_6 PF13522.6 AIF85502.1 - 2.1e-27 96.0 0.2 4.4e-17 62.5 0.0 2.5 1 1 0 2 2 2 2 Glutamine amidotransferase domain QueC PF06508.13 AIF85502.1 - 0.0046 16.5 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 AIF85502.1 - 0.018 15.1 0.2 0.087 12.9 0.0 2.1 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family NAD_synthase PF02540.17 AIF85502.1 - 0.03 13.4 0.0 0.077 12.1 0.0 1.7 1 0 0 1 1 1 0 NAD synthase PBP3 PF18056.1 AIF85502.1 - 0.24 11.5 1.3 4.2 7.6 0.4 2.4 2 0 0 2 2 2 0 Penicillin Binding Protein 3 Domain MS_channel PF00924.18 AIF85506.1 - 2.2e-46 158.0 0.2 2.2e-46 158.0 0.2 1.4 2 0 0 2 2 2 1 Mechanosensitive ion channel DUF3341 PF11821.8 AIF85506.1 - 0.034 13.8 0.2 0.034 13.8 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3341) FtsX PF02687.21 AIF85506.1 - 5.3 7.6 9.8 1.7 9.1 1.4 2.3 1 1 1 2 2 2 0 FtsX-like permease family DUF1326 PF07040.11 AIF85507.1 - 2.1e-53 181.0 0.0 2.5e-53 180.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) TrkH PF02386.16 AIF85509.1 - 1.7e-34 119.2 23.7 3.5e-34 118.1 23.7 1.5 1 1 0 1 1 1 1 Cation transport protein CBS PF00571.28 AIF85509.1 - 2.4e-18 66.3 1.0 1.1e-09 38.5 0.1 2.6 2 0 0 2 2 2 2 CBS domain Band_7 PF01145.25 AIF85510.1 - 9.1e-27 94.2 13.4 1.5e-26 93.5 13.4 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family DUF3792 PF12670.7 AIF85510.1 - 0.37 11.0 6.1 0.1 12.8 1.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) Na_H_Exchanger PF00999.21 AIF85512.1 - 1.3e-61 208.5 48.3 1.7e-61 208.1 48.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Neur_chan_memb PF02932.16 AIF85513.1 - 4.9e-06 26.8 4.1 7.5e-06 26.2 4.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region COX2_TM PF02790.15 AIF85513.1 - 0.67 10.1 6.9 4.9 7.4 0.4 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain Usp PF00582.26 AIF85515.1 - 1.1e-06 29.2 0.1 2e-06 28.3 0.1 1.5 1 1 0 1 1 1 1 Universal stress protein family HTH_45 PF14947.6 AIF85519.1 - 1.6e-18 66.5 0.1 2.1e-18 66.1 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIF85519.1 - 0.029 14.1 0.0 0.034 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) Usp PF00582.26 AIF85521.1 - 2.5e-32 112.3 0.7 3e-32 112.1 0.7 1.1 1 0 0 1 1 1 1 Universal stress protein family DUF3180 PF11377.8 AIF85522.1 - 0.033 14.3 0.7 0.039 14.1 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3180) TMEM169 PF15052.6 AIF85522.1 - 0.063 13.4 0.1 0.068 13.3 0.1 1.2 1 0 0 1 1 1 0 TMEM169 protein family DUF4079 PF13301.6 AIF85522.1 - 0.069 13.3 1.3 0.11 12.6 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) DUF2681 PF10883.8 AIF85522.1 - 0.16 12.4 0.9 0.23 11.9 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) FeoB_associated PF12669.7 AIF85522.1 - 0.2 12.1 6.5 3.9 7.9 0.0 2.2 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein DUF3040 PF11239.8 AIF85522.1 - 2 8.8 3.8 1 9.7 2.1 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) DUF202 PF02656.15 AIF85523.1 - 2.2e-18 66.4 2.2 2.2e-18 66.4 2.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF4199 PF13858.6 AIF85523.1 - 0.02 15.3 1.9 0.02 15.3 1.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) DUF4271 PF14093.6 AIF85523.1 - 0.02 14.8 1.4 0.025 14.5 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) Trp_oprn_chp PF09534.10 AIF85523.1 - 0.11 12.2 1.0 1.1 9.0 0.1 2.0 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PepSY PF03413.19 AIF85524.1 - 3.3e-09 37.2 1.9 6.3e-06 26.7 0.3 2.3 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain PepSY_2 PF13670.6 AIF85524.1 - 0.066 13.2 0.9 13 5.9 0.0 3.3 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain Transposase_31 PF04754.12 AIF85524.1 - 0.088 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative transposase, YhgA-like DUF4407 PF14362.6 AIF85524.1 - 2.2 7.6 7.7 0.96 8.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF4451 PF14616.6 AIF85525.1 - 0.0022 18.2 0.4 0.59 10.3 0.0 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4451) DUF1178 PF06676.11 AIF85525.1 - 0.22 11.9 1.6 0.24 11.8 0.2 1.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1178) DUF2182 PF09948.9 AIF85527.1 - 4.8e-56 189.6 21.2 4.8e-55 186.4 21.2 2.1 1 1 0 1 1 1 1 Predicted metal-binding integral membrane protein (DUF2182) DUF1326 PF07040.11 AIF85528.1 - 2.4e-50 171.0 0.0 2.9e-50 170.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) Methyltransf_31 PF13847.6 AIF85530.1 - 1.2e-23 83.6 0.0 1.3e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIF85530.1 - 4.5e-21 75.3 0.0 7.9e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIF85530.1 - 4.2e-20 72.3 0.0 7.6e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIF85530.1 - 2.4e-16 60.0 0.0 2.8e-16 59.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIF85530.1 - 4e-11 43.5 0.0 6.6e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIF85530.1 - 8.2e-11 41.7 0.0 1e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 AIF85530.1 - 2.8e-06 27.0 0.0 4.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 AIF85530.1 - 1.3e-05 25.0 0.0 1.7e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 AIF85530.1 - 4.4e-05 23.5 0.0 6.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 AIF85530.1 - 5.7e-05 22.7 0.0 8.1e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 AIF85530.1 - 0.00012 21.6 0.0 0.00062 19.3 0.0 1.8 1 1 1 2 2 2 1 Putative methyltransferase Methyltransf_2 PF00891.18 AIF85530.1 - 0.0002 20.7 0.0 0.00024 20.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain TehB PF03848.14 AIF85530.1 - 0.00062 19.2 0.0 0.00093 18.7 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB MetW PF07021.12 AIF85530.1 - 0.00087 18.9 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.11 AIF85530.1 - 0.0023 16.9 0.0 0.0029 16.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) NodS PF05401.11 AIF85530.1 - 0.0027 17.4 0.0 0.0032 17.1 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) CMAS PF02353.20 AIF85530.1 - 0.0055 16.0 0.0 0.007 15.7 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Met_10 PF02475.16 AIF85530.1 - 0.046 13.5 0.0 0.058 13.1 0.0 1.1 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_29 PF03141.16 AIF85530.1 - 0.087 11.4 0.0 0.12 10.9 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF4530 PF15039.6 AIF85530.1 - 0.19 11.9 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) Methyltransf_18 PF12847.7 AIF85530.1 - 0.2 11.5 0.0 0.3 11.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Na_H_Exchanger PF00999.21 AIF85533.1 - 6e-62 209.6 46.6 7.3e-62 209.3 46.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family MarR_2 PF12802.7 AIF85535.1 - 0.015 15.2 0.1 0.027 14.4 0.1 1.4 1 0 0 1 1 1 0 MarR family FecCD PF01032.18 AIF85535.1 - 0.043 12.8 0.1 0.059 12.4 0.1 1.1 1 0 0 1 1 1 0 FecCD transport family DUF4680 PF15730.5 AIF85535.1 - 0.11 12.8 0.4 0.11 12.8 0.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4680) CopG_antitoxin PF12441.8 AIF85536.1 - 0.0093 16.5 0.0 0.02 15.4 0.0 1.5 1 0 0 1 1 1 1 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIF85536.1 - 0.041 13.7 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 HicB family Big_7 PF17957.1 AIF85537.1 - 6.2e-08 33.3 3.3 1.3e-07 32.3 2.9 1.7 1 1 0 1 1 1 1 Bacterial Ig domain TerC PF03741.16 AIF85538.1 - 8.2e-52 175.5 11.7 1.7e-51 174.5 11.7 1.5 1 0 0 1 1 1 1 Integral membrane protein TerC family LapA_dom PF06305.11 AIF85538.1 - 0.034 13.9 2.8 0.27 11.1 0.0 3.5 3 1 0 3 3 3 0 Lipopolysaccharide assembly protein A domain PepSY PF03413.19 AIF85539.1 - 3.6e-08 33.8 0.6 7.1e-08 32.9 0.6 1.6 1 1 0 1 1 1 1 Peptidase propeptide and YPEB domain PepSY_2 PF13670.6 AIF85539.1 - 0.1 12.6 2.1 1.3 9.0 0.0 2.2 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Band_7 PF01145.25 AIF85541.1 - 1.3e-16 61.1 19.0 3.9e-16 59.6 19.0 1.7 1 1 0 1 1 1 1 SPFH domain / Band 7 family T3SSipB PF16535.5 AIF85541.1 - 0.00097 19.6 3.5 0.0022 18.5 3.5 1.6 1 0 0 1 1 1 1 Type III cell invasion protein SipB DUF4652 PF15525.6 AIF85541.1 - 0.027 14.2 0.6 0.06 13.1 0.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4652) Myco_haema PF05692.12 AIF85541.1 - 0.028 13.4 0.8 0.038 13.0 0.5 1.3 1 1 0 1 1 1 0 Mycoplasma haemagglutinin Na_sulph_symp PF00939.19 AIF85542.1 - 5.9e-76 256.4 31.4 7.8e-76 256.0 31.4 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 AIF85542.1 - 3.3e-45 154.6 54.0 5.3e-40 137.5 28.3 2.2 1 1 1 2 2 2 2 Citrate transporter Usp PF00582.26 AIF85543.1 - 1.9e-18 67.3 0.4 2.2e-18 67.1 0.4 1.0 1 0 0 1 1 1 1 Universal stress protein family Band_7 PF01145.25 AIF85544.1 - 2.8e-33 115.4 0.3 2.8e-33 115.4 0.3 1.5 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 AIF85544.1 - 1.6e-05 24.8 0.0 2.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 SPFH domain-Band 7 family NfeD PF01957.18 AIF85545.1 - 1.6e-09 38.0 0.2 4.5e-09 36.6 0.2 1.9 1 0 0 1 1 1 1 NfeD-like C-terminal, partner-binding CLP_protease PF00574.23 AIF85545.1 - 6.4e-06 26.2 0.7 2.7e-05 24.1 0.5 2.1 2 0 0 2 2 2 1 Clp protease SDH_sah PF01972.16 AIF85545.1 - 0.0032 16.5 0.3 0.0052 15.8 0.3 1.3 1 0 0 1 1 1 1 Serine dehydrogenase proteinase Copper-bind PF00127.20 AIF85548.1 - 0.066 13.7 0.3 1.1 9.8 0.1 2.7 2 1 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family Usp PF00582.26 AIF85549.1 - 4.6e-08 33.7 0.1 5e-08 33.6 0.1 1.1 1 0 0 1 1 1 1 Universal stress protein family UPF0060 PF02694.15 AIF85550.1 - 6.4e-16 58.5 3.9 7.3e-16 58.3 3.9 1.0 1 0 0 1 1 1 1 Uncharacterised BCR, YnfA/UPF0060 family Lactonase PF10282.9 AIF85551.1 - 4.2e-07 29.6 0.4 0.49 9.6 0.1 4.2 2 2 2 5 5 5 4 Lactonase, 7-bladed beta-propeller SGL PF08450.12 AIF85551.1 - 1e-05 25.3 0.1 0.02 14.5 0.2 3.2 1 1 2 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 AIF85551.1 - 0.0016 18.6 1.9 35 4.7 0.1 4.4 2 1 2 4 4 4 1 Arylesterase CBM60 PF16841.5 AIF85551.1 - 0.055 13.9 0.1 0.16 12.4 0.1 1.8 1 0 0 1 1 1 0 Ca-dependent carbohydrate-binding module xylan-binding FlaG PF03646.15 AIF85551.1 - 0.15 12.2 10.7 13 6.1 0.1 4.7 5 0 0 5 5 5 0 FlaG protein Copper-bind PF00127.20 AIF85553.1 - 4.2e-09 36.7 0.0 6e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF85553.1 - 8.1e-06 25.9 0.1 1.9e-05 24.7 0.1 1.7 1 1 0 1 1 1 1 Cupredoxin-like domain Aminotran_1_2 PF00155.21 AIF85555.1 - 1e-33 117.0 0.0 1.9e-33 116.1 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Copper-bind PF00127.20 AIF85555.1 - 0.0043 17.5 0.0 0.02 15.3 0.0 2.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF85555.1 - 0.015 15.4 0.1 0.11 12.6 0.0 2.3 2 0 0 2 2 2 0 Cupredoxin-like domain DUF202 PF02656.15 AIF85556.1 - 2.3e-15 56.8 0.9 3e-15 56.4 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF202) DUF2207 PF09972.9 AIF85556.1 - 0.054 12.3 0.0 0.055 12.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PDZ_2 PF13180.6 AIF85560.1 - 0.012 15.9 0.0 0.066 13.5 0.0 2.2 1 1 0 1 1 1 0 PDZ domain FTO_CTD PF12934.7 AIF85561.1 - 0.0056 16.5 1.6 0.017 14.9 0.1 2.5 2 1 0 2 2 2 1 FTO C-terminal domain Copper-bind PF00127.20 AIF85562.1 - 2.8e-07 30.9 0.0 5.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIF85562.1 - 1.7e-06 28.1 0.0 3.6e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Cupredoxin-like domain PepSY PF03413.19 AIF85562.1 - 0.00021 21.8 0.2 0.15 12.6 0.0 2.7 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain Inositol_P PF00459.25 AIF85563.1 - 1.6e-27 96.7 0.3 1.8e-27 96.5 0.3 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.20 AIF85563.1 - 0.00015 21.3 0.0 0.00025 20.6 0.0 1.4 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain FBPase_glpX PF03320.13 AIF85563.1 - 0.026 13.4 0.0 0.047 12.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial fructose-1,6-bisphosphatase, glpX-encoded HTH_24 PF13412.6 AIF85564.1 - 1.5e-21 75.7 4.1 1.2e-10 40.8 0.1 2.5 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIF85564.1 - 1.8e-20 72.5 4.6 1.7e-09 37.3 0.0 3.0 3 0 0 3 3 3 2 AsnC-type helix-turn-helix domain MarR PF01047.22 AIF85564.1 - 1e-07 31.8 0.3 5.8e-05 22.9 0.1 2.9 3 0 0 3 3 2 1 MarR family MarR_2 PF12802.7 AIF85564.1 - 5.5e-07 29.4 0.3 9.6e-05 22.2 0.0 3.0 3 0 0 3 3 3 1 MarR family HTH_Mga PF08280.11 AIF85564.1 - 7.2e-06 25.9 0.1 0.0062 16.5 0.1 2.4 2 0 0 2 2 2 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_20 PF12840.7 AIF85564.1 - 7.6e-06 25.9 0.1 0.0092 16.0 0.2 2.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 AIF85564.1 - 7.6e-06 25.6 0.1 2.1e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Crp_2 PF13545.6 AIF85564.1 - 6.5e-05 22.8 0.4 0.076 13.0 0.1 2.5 2 0 0 2 2 2 2 Crp-like helix-turn-helix domain HTH_28 PF13518.6 AIF85564.1 - 0.0001 22.3 0.1 0.00038 20.5 0.0 2.0 2 0 0 2 2 1 1 Helix-turn-helix domain HTH_11 PF08279.12 AIF85564.1 - 0.00011 22.0 0.2 0.00032 20.6 0.1 1.8 2 0 0 2 2 1 1 HTH domain HTH_5 PF01022.20 AIF85564.1 - 0.00013 21.7 0.3 0.00031 20.6 0.3 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_IclR PF09339.10 AIF85564.1 - 0.00016 21.4 0.1 0.00054 19.7 0.1 1.8 2 0 0 2 2 2 1 IclR helix-turn-helix domain Sigma70_r4_2 PF08281.12 AIF85564.1 - 0.0015 18.1 0.8 0.019 14.6 0.2 2.6 3 0 0 3 3 2 1 Sigma-70, region 4 HTH_29 PF13551.6 AIF85564.1 - 0.0018 18.2 0.1 0.0051 16.8 0.1 1.7 1 0 0 1 1 1 1 Winged helix-turn helix Mga PF05043.13 AIF85564.1 - 0.0033 18.0 0.0 0.007 16.9 0.0 1.6 1 0 0 1 1 1 1 Mga helix-turn-helix domain HTH_30 PF13556.6 AIF85564.1 - 0.0039 17.0 0.0 0.0095 15.7 0.0 1.7 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain GerE PF00196.19 AIF85564.1 - 0.0054 16.2 0.1 0.34 10.5 0.0 2.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, luxR family HTH_10 PF04967.12 AIF85564.1 - 0.0084 15.9 0.3 0.025 14.4 0.1 1.9 2 0 0 2 2 2 1 HTH DNA binding domain HTH_Tnp_ISL3 PF13542.6 AIF85564.1 - 0.0086 15.5 0.0 0.026 13.9 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 GntR PF00392.21 AIF85564.1 - 0.013 15.2 0.3 0.1 12.3 0.2 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family Fe_dep_repress PF01325.19 AIF85564.1 - 0.022 15.0 0.0 0.048 13.9 0.0 1.5 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain TrmB PF01978.19 AIF85564.1 - 0.03 14.2 0.1 1.3 8.9 0.0 2.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF2089 PF09862.9 AIF85564.1 - 0.058 13.4 0.1 0.92 9.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2089) HTH_DeoR PF08220.12 AIF85564.1 - 0.062 13.1 0.1 0.16 11.7 0.1 1.7 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HxlR PF01638.17 AIF85564.1 - 0.062 13.2 0.0 5.7 6.9 0.0 2.5 2 0 0 2 2 2 0 HxlR-like helix-turn-helix HTH_1 PF00126.27 AIF85564.1 - 0.063 13.2 0.1 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family Sigma70_r4 PF04545.16 AIF85564.1 - 0.065 12.8 0.3 0.21 11.1 0.3 1.9 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_7 PF02796.15 AIF85564.1 - 0.065 13.3 0.1 0.68 10.1 0.1 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase TNV_CP PF03898.13 AIF85564.1 - 0.073 12.3 0.5 0.16 11.2 0.5 1.5 1 1 0 1 1 1 0 Satellite tobacco necrosis virus coat protein HTH_27 PF13463.6 AIF85564.1 - 0.089 13.3 0.1 0.61 10.6 0.1 2.3 2 0 0 2 2 2 0 Winged helix DNA-binding domain HTH_8 PF02954.19 AIF85564.1 - 0.15 11.9 0.1 0.31 10.9 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family YPEB PF14620.6 AIF85564.1 - 0.18 11.1 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 YpeB sporulation DNA_pol3_delta PF06144.13 AIF85565.1 - 0.0068 16.2 0.0 0.013 15.3 0.0 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit CMD PF02627.20 AIF85565.1 - 0.074 13.1 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family Pro_dh PF01619.18 AIF85566.1 - 1.4e-27 97.0 0.0 2.7e-27 96.1 0.0 1.4 1 1 0 1 1 1 1 Proline dehydrogenase Aldedh PF00171.22 AIF85567.1 - 4.4e-153 510.1 0.2 5.7e-153 509.7 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 AIF85567.1 - 0.017 14.2 0.0 0.04 13.0 0.0 1.5 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) Cupredoxin_1 PF13473.6 AIF85568.1 - 4.4e-08 33.2 0.1 6.2e-08 32.7 0.1 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 AIF85568.1 - 0.0036 17.7 0.5 0.0078 16.6 0.4 1.6 1 1 1 2 2 2 1 Copper binding proteins, plastocyanin/azurin family Tam41_Mmp37 PF09139.11 AIF85568.1 - 0.053 13.0 0.6 0.064 12.7 0.6 1.1 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial Peroxin-13_N PF04088.13 AIF85569.1 - 0.0014 19.0 0.0 0.0026 18.1 0.0 1.4 2 0 0 2 2 2 1 Peroxin 13, N-terminal region LapA_dom PF06305.11 AIF85569.1 - 0.29 11.0 0.0 0.29 11.0 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain HTH_45 PF14947.6 AIF85570.1 - 2.2e-08 33.9 0.1 3.2e-08 33.5 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIF85570.1 - 0.0093 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 AIF85570.1 - 0.04 14.4 0.0 0.066 13.7 0.0 1.5 1 1 0 1 1 1 0 Winged helix DNA-binding domain PadR PF03551.14 AIF85570.1 - 0.053 13.5 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_34 PF13601.6 AIF85570.1 - 0.12 12.5 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain TrmB PF01978.19 AIF85570.1 - 0.14 12.0 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB FtsK_gamma PF09397.10 AIF85570.1 - 0.16 11.8 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Ftsk gamma domain DUF3328 PF11807.8 AIF85571.1 - 0.057 13.2 0.1 0.057 13.2 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) DUF1180 PF06679.12 AIF85571.1 - 0.062 13.7 0.8 0.066 13.6 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF87 PF01935.17 AIF85572.1 - 8.7e-15 55.4 0.2 8.7e-15 55.4 0.2 3.0 3 1 0 3 3 3 1 Helicase HerA, central domain DUF853 PF05872.12 AIF85572.1 - 1.9e-08 33.3 9.7 2.1e-08 33.3 0.0 3.2 3 0 0 3 3 3 2 Bacterial protein of unknown function (DUF853) AAA_10 PF12846.7 AIF85572.1 - 6.4e-06 25.3 0.0 0.00038 19.5 0.0 2.6 2 0 0 2 2 2 1 AAA-like domain FtsK_SpoIIIE PF01580.18 AIF85572.1 - 8.1e-05 22.1 1.1 0.00012 21.5 0.0 1.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family DotD PF16816.5 AIF85572.1 - 0.00033 20.6 0.1 0.001 19.0 0.1 1.8 1 0 0 1 1 1 1 DotD protein TrwB_AAD_bind PF10412.9 AIF85572.1 - 0.0022 17.0 0.0 0.0058 15.6 0.0 1.7 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA_18 PF13238.6 AIF85572.1 - 0.0084 16.7 0.0 0.049 14.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 AIF85572.1 - 0.064 13.0 0.6 1.7 8.3 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 AIF85572.1 - 0.52 10.8 0.0 0.52 10.8 0.0 3.1 3 1 0 3 3 3 0 ABC transporter RibD_C PF01872.17 AIF85573.1 - 6.1e-47 160.0 1.1 7e-47 159.9 1.1 1.0 1 0 0 1 1 1 1 RibD C-terminal domain His_biosynth PF00977.21 AIF85573.1 - 0.011 15.2 0.7 2.7 7.4 0.1 2.1 1 1 1 2 2 2 0 Histidine biosynthesis protein Amidohydro_1 PF01979.20 AIF85574.1 - 5.5e-47 160.7 1.9 6.4e-47 160.5 1.9 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 AIF85574.1 - 3.2e-16 59.9 6.7 1.6e-10 41.1 1.2 3.1 1 1 1 2 2 2 2 Amidohydrolase family GCH_III PF05165.12 AIF85575.1 - 3.4e-57 193.5 0.8 3.8e-57 193.4 0.8 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase III Guanylate_cyc PF00211.20 AIF85575.1 - 0.0011 18.7 0.2 0.0049 16.5 0.0 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain DMRL_synthase PF00885.19 AIF85576.1 - 1.9e-36 125.0 0.5 2.1e-36 124.8 0.5 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase DHBP_synthase PF00926.19 AIF85577.1 - 2.2e-59 200.2 0.8 2.6e-59 200.0 0.8 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase Lum_binding PF00677.17 AIF85579.1 - 4e-47 158.1 1.5 1.1e-24 86.2 0.1 2.1 2 0 0 2 2 2 2 Lumazine binding domain MazE_antitoxin PF04014.18 AIF85579.1 - 0.01 15.7 0.2 6.9 6.7 0.0 3.2 3 0 0 3 3 3 0 Antidote-toxin recognition MazE, bacterial antitoxin SH3_15 PF18346.1 AIF85579.1 - 0.049 14.0 0.7 1.5 9.2 0.0 3.0 2 1 1 3 3 3 0 Mind bomb SH3 repeat domain ATP-synt_ab_Xtn PF16886.5 AIF85579.1 - 0.076 12.9 0.0 0.15 11.9 0.0 1.6 1 1 0 1 1 1 0 ATPsynthase alpha/beta subunit N-term extension Hist_deacetyl PF00850.19 AIF85580.1 - 5.4e-69 233.0 0.1 6.3e-69 232.8 0.1 1.0 1 0 0 1 1 1 1 Histone deacetylase domain SHMT PF00464.19 AIF85581.1 - 1.2e-72 244.7 0.1 1.8e-72 244.1 0.1 1.2 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 AIF85581.1 - 6.8e-06 25.6 0.0 1.7e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 AIF85581.1 - 3.3e-05 23.2 0.0 9.1e-05 21.8 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AIF85581.1 - 0.0012 17.9 0.3 0.0031 16.5 0.3 1.9 1 1 0 1 1 1 1 Aminotransferase class-V SelA PF03841.13 AIF85581.1 - 0.0014 17.7 0.0 0.0026 16.8 0.0 1.4 1 0 0 1 1 1 1 L-seryl-tRNA selenium transferase TssO PF17561.2 AIF85581.1 - 0.089 12.9 0.8 0.33 11.1 0.2 2.0 2 0 0 2 2 2 0 Type VI secretion system, TssO DUF3150 PF11348.8 AIF85582.1 - 0.075 12.3 1.2 0.069 12.4 1.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) SseC PF04888.12 AIF85582.1 - 0.083 12.5 0.9 0.08 12.5 0.9 1.0 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF2204 PF09970.9 AIF85583.1 - 0.07 12.8 0.5 0.88 9.2 0.1 2.0 2 0 0 2 2 2 0 Nucleotidyl transferase of unknown function (DUF2204) AP2 PF00847.20 AIF85583.1 - 0.54 10.5 2.3 3.6 7.9 0.2 2.3 2 0 0 2 2 2 0 AP2 domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Candidatus_Nitrososphaera_evergladensis_SR1-ASM73028v1/GCA_000730285.1_ASM73028v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Candidatus_Nitrososphaera_evergladensis_SR1-ASM73028v1/GCA_000730285.1_ASM73028v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Candidatus_Nitrososphaera_evergladensis_SR1-ASM73028v1/GCA_000730285.1_ASM73028v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Candidatus_Nitrososphaera_evergladensis_SR1-ASM73028v1/GCA_000730285.1_ASM73028v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 16:31:48 2019 # [ok]